# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- Fungal_trans PF04082.18 EXF72904.1 - 3.5e-31 108.2 0.0 1.3e-30 106.4 0.0 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF72904.1 - 1e-10 41.6 13.6 1.9e-10 40.7 13.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fer2 PF00111.27 EXF72904.1 - 0.091 12.7 2.9 1.4 8.9 0.0 2.4 2 0 0 2 2 2 0 2Fe-2S iron-sulfur cluster binding domain Gal4_dimer PF03902.13 EXF72904.1 - 0.14 12.4 0.1 0.45 10.7 0.1 1.9 1 0 0 1 1 1 0 Gal4-like dimerisation domain Sugarporin_N PF11471.8 EXF72904.1 - 4.3 7.4 5.1 11 6.1 0.8 2.9 2 0 0 2 2 2 0 Maltoporin periplasmic N-terminal extension Peptidase_C65 PF10275.9 EXF72905.1 - 1.2e-67 227.9 0.0 2.5e-67 226.9 0.0 1.5 1 0 0 1 1 1 1 Peptidase C65 Otubain PCI PF01399.27 EXF72907.1 - 1.7e-19 70.2 0.3 4.5e-19 68.9 0.0 1.9 2 0 0 2 2 2 1 PCI domain TPR_12 PF13424.6 EXF72907.1 - 0.027 14.7 0.3 15 6.0 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 EXF72907.1 - 0.11 12.6 4.2 0.93 9.8 0.3 4.2 5 0 0 5 5 5 0 Tetratricopeptide repeat CWC25 PF12542.8 EXF72908.1 - 1.2e-23 83.9 0.3 1.2e-23 83.9 0.3 4.1 3 2 1 4 4 4 1 Pre-mRNA splicing factor Cir_N PF10197.9 EXF72908.1 - 1.5e-13 50.6 7.3 1.5e-13 50.6 7.3 4.2 3 1 1 4 4 4 1 N-terminal domain of CBF1 interacting co-repressor CIR Ras PF00071.22 EXF72909.1 - 1.3e-54 184.2 0.0 1.5e-54 183.9 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EXF72909.1 - 1.7e-21 76.6 0.0 3.3e-21 75.7 0.0 1.4 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EXF72909.1 - 1.2e-09 37.8 0.0 1.9e-09 37.3 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EXF72909.1 - 0.00039 19.8 0.0 0.00051 19.5 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.20 EXF72909.1 - 0.0018 17.5 0.0 0.002 17.3 0.0 1.2 1 0 0 1 1 1 1 G-protein alpha subunit MMR_HSR1 PF01926.23 EXF72909.1 - 0.0051 16.9 0.0 0.011 15.8 0.0 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 EXF72909.1 - 0.0086 15.5 0.0 0.012 15.1 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit ABC_tran PF00005.27 EXF72909.1 - 0.097 13.2 0.0 0.13 12.8 0.0 1.5 1 1 0 1 1 1 0 ABC transporter DUF1275 PF06912.11 EXF72911.1 - 5.9e-50 169.9 5.8 7.9e-50 169.5 5.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1275) MFS_1 PF07690.16 EXF72911.1 - 0.0017 17.4 9.4 0.014 14.4 2.3 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily DUF4131 PF13567.6 EXF72911.1 - 0.0029 17.3 3.0 1 9.0 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF4131) Glyco_hydro_16 PF00722.21 EXF72912.1 - 3.1e-38 131.0 1.8 5.6e-38 130.2 1.8 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 Fungal_trans_2 PF11951.8 EXF72914.1 - 4.1e-42 144.4 0.1 6.4e-42 143.7 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF72914.1 - 8.4e-07 29.0 6.5 1.5e-06 28.2 6.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain HisKA_3 PF07730.13 EXF72914.1 - 0.031 14.8 6.3 6.3 7.4 0.0 3.7 4 0 0 4 4 4 0 Histidine kinase eIF-3_zeta PF05091.12 EXF72914.1 - 0.23 10.4 0.0 0.36 9.8 0.0 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) ADH_N PF08240.12 EXF72915.1 - 5.3e-26 90.6 3.8 1.2e-25 89.4 3.8 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EXF72915.1 - 1.7e-14 53.9 0.1 2.7e-14 53.3 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EXF72915.1 - 9.9e-05 21.9 0.5 0.0016 18.0 0.3 2.2 2 0 0 2 2 2 1 Glucose dehydrogenase C-terminus adh_short_C2 PF13561.6 EXF72916.1 - 4.8e-59 199.8 0.3 5.6e-59 199.5 0.3 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF72916.1 - 6.7e-52 175.8 0.7 8.5e-52 175.5 0.7 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EXF72916.1 - 1.6e-17 64.0 0.1 2.2e-17 63.6 0.1 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EXF72916.1 - 1.2e-06 28.2 0.4 8.1e-06 25.5 0.4 2.2 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EXF72916.1 - 0.16 11.3 0.0 4.5 6.6 0.0 2.1 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase DUF4246 PF14033.6 EXF72917.1 - 6.8e-160 533.1 0.0 1.2e-159 532.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF4246) 2OG-FeII_Oxy_5 PF13759.6 EXF72917.1 - 0.074 13.5 0.0 0.16 12.4 0.0 1.5 1 0 0 1 1 1 0 Putative 2OG-Fe(II) oxygenase Sugar_tr PF00083.24 EXF72918.1 - 2.1e-90 303.7 19.1 2.6e-90 303.5 19.1 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF72918.1 - 7.3e-16 58.0 42.3 3e-08 33.0 21.2 2.1 1 1 0 2 2 2 2 Major Facilitator Superfamily Aminotran_1_2 PF00155.21 EXF72919.1 - 3e-35 122.1 0.0 3.6e-35 121.8 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 EXF72919.1 - 4.7e-07 29.1 0.0 1e-06 28.0 0.0 1.5 2 0 0 2 2 2 1 Aminotransferase class-V Aminotran_MocR PF12897.7 EXF72919.1 - 0.00011 21.2 0.0 0.00013 20.9 0.0 1.2 1 0 0 1 1 1 1 Alanine-glyoxylate amino-transferase Cys_Met_Meta_PP PF01053.20 EXF72919.1 - 0.00051 18.7 0.0 0.00076 18.1 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Beta_elim_lyase PF01212.21 EXF72919.1 - 0.037 13.3 0.0 0.052 12.8 0.0 1.2 1 0 0 1 1 1 0 Beta-eliminating lyase Alliinase_C PF04864.13 EXF72919.1 - 0.13 11.2 0.1 0.27 10.1 0.1 1.6 1 1 0 1 1 1 0 Allinase CPSase_L_D2 PF02786.17 EXF72920.1 - 4.7e-71 238.6 0.0 7.1e-71 238.1 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_C PF02785.19 EXF72920.1 - 3.1e-38 130.2 0.0 2.6e-37 127.2 0.0 2.3 2 0 0 2 2 2 1 Biotin carboxylase C-terminal domain Biotin_carb_N PF00289.22 EXF72920.1 - 3.2e-37 127.4 0.0 7.2e-37 126.3 0.0 1.6 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_lipoyl PF00364.22 EXF72920.1 - 4.5e-16 58.4 2.3 1.7e-15 56.6 1.6 2.5 2 0 0 2 2 2 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 EXF72920.1 - 5.5e-08 32.5 0.1 0.00038 20.2 0.0 2.9 2 1 1 3 3 3 2 Biotin-lipoyl like Dala_Dala_lig_C PF07478.13 EXF72920.1 - 1.4e-06 28.0 0.0 4.3e-06 26.4 0.0 1.9 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus HlyD_3 PF13437.6 EXF72920.1 - 3.5e-05 24.4 0.1 0.52 11.0 0.0 3.0 2 0 0 2 2 2 2 HlyD family secretion protein HlyD_D23 PF16576.5 EXF72920.1 - 0.0033 16.7 0.1 1.2 8.3 0.0 3.0 2 1 1 3 3 3 2 Barrel-sandwich domain of CusB or HlyD membrane-fusion ATP-grasp_3 PF02655.14 EXF72920.1 - 0.0034 17.4 0.0 0.0081 16.2 0.0 1.7 1 0 0 1 1 1 1 ATP-grasp domain RimK PF08443.11 EXF72920.1 - 0.005 16.4 0.0 0.029 14.0 0.0 2.0 1 1 0 1 1 1 1 RimK-like ATP-grasp domain Putative_PNPOx PF01243.20 EXF72921.1 - 8.1e-15 54.8 0.0 1.3e-13 50.9 0.0 2.1 2 0 0 2 2 2 1 Pyridoxamine 5'-phosphate oxidase Pyridox_ox_2 PF12900.7 EXF72921.1 - 0.0011 19.0 0.0 0.059 13.4 0.0 2.2 2 0 0 2 2 2 1 Pyridoxamine 5'-phosphate oxidase Gpi16 PF04113.14 EXF72921.1 - 0.022 13.2 0.1 0.028 12.9 0.1 1.1 1 0 0 1 1 1 0 Gpi16 subunit, GPI transamidase component Methyltransf_23 PF13489.6 EXF72922.1 - 1.9e-15 57.1 0.0 3.3e-15 56.3 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF72922.1 - 5.3e-13 49.5 0.0 1.4e-12 48.2 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF72922.1 - 2e-09 38.1 0.1 7.5e-09 36.2 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF72922.1 - 4.1e-09 37.0 0.0 9.1e-09 35.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF72922.1 - 3.4e-08 33.4 0.0 2.4e-07 30.7 0.0 2.2 1 1 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 EXF72922.1 - 0.00014 21.3 0.0 0.00036 19.9 0.0 1.7 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.17 EXF72922.1 - 0.00016 21.2 0.0 0.00071 19.1 0.0 1.9 2 0 0 2 2 2 1 Putative methyltransferase MTS PF05175.14 EXF72922.1 - 0.00026 20.6 0.0 0.00087 18.9 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_2 PF00891.18 EXF72922.1 - 0.0011 18.3 0.0 0.011 15.0 0.0 2.3 2 1 0 2 2 2 1 O-methyltransferase domain CMAS PF02353.20 EXF72922.1 - 0.076 12.3 0.0 0.17 11.1 0.0 1.5 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase Gln-synt_C PF00120.24 EXF72923.1 - 2.7e-86 289.7 0.0 3.3e-86 289.4 0.0 1.1 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain adh_short_C2 PF13561.6 EXF72924.1 - 4.7e-58 196.5 0.3 5.4e-58 196.3 0.3 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF72924.1 - 4.2e-41 140.6 0.2 5.2e-41 140.3 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EXF72924.1 - 1.4e-07 31.6 1.3 2.1e-07 31.1 1.3 1.2 1 0 0 1 1 1 1 KR domain 3HCDH_N PF02737.18 EXF72924.1 - 0.00017 21.5 0.1 0.00031 20.7 0.1 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Methyltransf_25 PF13649.6 EXF72924.1 - 0.0019 18.9 0.0 0.0036 18.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain ChuX_HutX PF06228.13 EXF72924.1 - 0.002 17.9 0.0 1.2 8.9 0.0 2.3 1 1 1 2 2 2 2 Haem utilisation ChuX/HutX THF_DHG_CYH_C PF02882.19 EXF72924.1 - 0.04 13.2 0.1 0.14 11.4 0.0 1.9 2 0 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Polysacc_synt_2 PF02719.15 EXF72924.1 - 0.064 12.4 0.0 0.093 11.8 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein UDPG_MGDP_dh_N PF03721.14 EXF72924.1 - 0.088 12.4 0.1 0.13 11.8 0.1 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain ICL PF00463.21 EXF72925.1 - 2.4e-201 669.8 0.2 2.8e-201 669.6 0.2 1.0 1 0 0 1 1 1 1 Isocitrate lyase family PEP_mutase PF13714.6 EXF72925.1 - 1.7e-12 47.3 0.1 1.5e-10 41.0 0.0 2.5 2 0 0 2 2 2 2 Phosphoenolpyruvate phosphomutase Citrate_synt PF00285.21 EXF72926.1 - 1.8e-101 339.9 0.0 2.1e-101 339.6 0.0 1.0 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain DUF4360 PF14273.6 EXF72927.1 - 4.1e-65 219.0 2.0 4.7e-65 218.8 2.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4360) Sulfate_transp PF00916.20 EXF72928.1 - 1.4e-87 294.0 22.2 1.9e-87 293.5 22.2 1.2 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 EXF72928.1 - 2e-12 46.8 0.0 4e-12 45.8 0.0 1.5 1 0 0 1 1 1 1 STAS domain STAS_2 PF13466.6 EXF72928.1 - 0.014 15.7 0.0 0.032 14.6 0.0 1.6 1 0 0 1 1 1 0 STAS domain DUF2070 PF09843.9 EXF72929.1 - 2.7 6.2 9.9 3.9 5.7 9.9 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) DUF1690 PF07956.11 EXF72929.1 - 3.1 8.2 5.7 25 5.3 5.7 2.2 1 1 0 1 1 1 0 Protein of Unknown function (DUF1690) Lactamase_B PF00753.27 EXF72930.1 - 1e-19 71.3 4.2 1.9e-19 70.4 4.2 1.4 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EXF72930.1 - 0.00026 20.6 0.3 0.00045 19.8 0.3 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Scytalone_dh PF02982.14 EXF72930.1 - 0.025 14.4 0.0 0.057 13.2 0.0 1.5 1 0 0 1 1 1 0 Scytalone dehydratase Pyr_redox_2 PF07992.14 EXF72931.1 - 4.2e-12 45.9 0.0 3.1e-08 33.2 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EXF72931.1 - 0.0032 17.1 0.2 0.0071 16.0 0.3 1.5 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EXF72931.1 - 0.019 15.0 0.0 0.12 12.4 0.0 2.0 2 0 0 2 2 2 0 FAD-NAD(P)-binding GH43_C2 PF17851.1 EXF72932.1 - 3.9e-07 30.0 0.0 1.9e-06 27.7 0.0 1.9 1 1 0 1 1 1 1 Beta xylosidase C-terminal Concanavalin A-like domain Glyco_hydro_43 PF04616.14 EXF72932.1 - 0.064 12.6 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolases family 43 Methyltransf_23 PF13489.6 EXF72933.1 - 6.2e-23 81.4 0.0 9.4e-23 80.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF72933.1 - 1.7e-09 38.3 0.0 3.6e-09 37.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF72933.1 - 8e-07 29.7 0.0 2.7e-06 28.0 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF72933.1 - 1e-06 28.6 0.0 8.7e-06 25.6 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF72933.1 - 1.7e-06 28.6 0.0 3.4e-06 27.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 EXF72933.1 - 0.0091 15.5 0.0 0.028 13.9 0.0 1.7 2 0 0 2 2 2 1 Putative methyltransferase MTS PF05175.14 EXF72933.1 - 0.058 12.9 0.0 0.092 12.3 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_2 PF00891.18 EXF72933.1 - 0.058 12.7 0.0 0.28 10.4 0.0 2.1 2 1 0 2 2 2 0 O-methyltransferase domain FtsJ PF01728.19 EXF72933.1 - 0.2 11.8 0.0 0.29 11.2 0.0 1.2 1 0 0 1 1 1 0 FtsJ-like methyltransferase Fungal_trans PF04082.18 EXF72934.1 - 1.3e-27 96.5 0.0 1.8e-27 96.1 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF72934.1 - 1.7e-06 28.0 8.3 3.1e-06 27.2 8.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain adh_short PF00106.25 EXF72935.1 - 3.1e-34 118.2 0.0 4.2e-34 117.7 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF72935.1 - 2.6e-24 86.1 0.0 6.6e-24 84.8 0.0 1.6 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 EXF72935.1 - 0.0014 18.2 0.0 0.0043 16.6 0.0 1.8 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family KR PF08659.10 EXF72935.1 - 0.011 15.7 0.0 0.022 14.6 0.0 1.4 1 0 0 1 1 1 0 KR domain Abhydrolase_1 PF00561.20 EXF72937.1 - 2.8e-24 86.2 0.2 3.2e-16 59.8 0.1 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EXF72937.1 - 1.2e-19 70.6 0.2 2.7e-18 66.1 0.2 2.0 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EXF72937.1 - 3.2e-17 63.9 0.0 4.2e-17 63.5 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 EXF72937.1 - 3.6e-07 29.9 0.1 0.015 14.7 0.0 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family Ndr PF03096.14 EXF72937.1 - 5e-05 22.1 0.0 6.1e-05 21.9 0.0 1.2 1 0 0 1 1 1 1 Ndr family Abhydrolase_4 PF08386.10 EXF72937.1 - 0.00013 22.1 0.0 0.00027 21.0 0.0 1.5 2 0 0 2 2 1 1 TAP-like protein FSH1 PF03959.13 EXF72937.1 - 0.0047 16.6 0.0 0.0079 15.9 0.0 1.4 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_5 PF12695.7 EXF72937.1 - 0.0065 16.3 0.0 0.55 10.0 0.0 2.2 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.13 EXF72937.1 - 0.016 15.1 0.0 0.048 13.5 0.0 1.8 1 1 0 1 1 1 0 alpha/beta hydrolase fold DUF2920 PF11144.8 EXF72937.1 - 0.038 13.2 0.0 0.061 12.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2920) AXE1 PF05448.12 EXF72937.1 - 0.1 11.3 0.2 2.2 6.9 0.0 2.5 2 1 1 3 3 3 0 Acetyl xylan esterase (AXE1) UPF0227 PF05728.12 EXF72937.1 - 0.12 12.3 0.0 0.29 11.1 0.0 1.7 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0227) MFS_1 PF07690.16 EXF72938.1 - 1.2e-35 123.1 27.9 1.2e-35 123.1 27.9 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily zf-RING_6 PF14835.6 EXF72938.1 - 0.44 10.4 2.2 2.2 8.2 0.2 2.4 2 0 0 2 2 2 0 zf-RING of BARD1-type protein Cutinase PF01083.22 EXF72939.1 - 6.4e-30 104.4 5.4 8.8e-30 104.0 5.4 1.2 1 0 0 1 1 1 1 Cutinase PE-PPE PF08237.11 EXF72939.1 - 0.0014 18.2 0.2 0.0018 17.9 0.2 1.2 1 0 0 1 1 1 1 PE-PPE domain Palm_thioest PF02089.15 EXF72939.1 - 0.0077 16.1 0.4 0.0081 16.0 0.4 1.1 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Abhydrolase_1 PF00561.20 EXF72939.1 - 0.014 15.1 0.1 0.017 14.8 0.1 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 EXF72939.1 - 0.015 15.1 0.0 0.022 14.6 0.0 1.2 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase Lipase_3 PF01764.25 EXF72939.1 - 0.017 15.0 0.2 0.023 14.6 0.2 1.4 1 0 0 1 1 1 0 Lipase (class 3) DLH PF01738.18 EXF72939.1 - 0.082 12.4 0.5 0.11 12.1 0.5 1.2 1 0 0 1 1 1 0 Dienelactone hydrolase family GH131_N PF18271.1 EXF72940.1 - 9.5e-73 245.0 0.1 1.1e-72 244.9 0.1 1.0 1 0 0 1 1 1 1 Glycoside hydrolase 131 catalytic N-terminal domain p450 PF00067.22 EXF72941.1 - 2e-70 237.9 0.0 2.4e-70 237.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 AA_permease PF00324.21 EXF72943.1 - 7.9e-92 308.3 37.4 9.7e-92 308.0 37.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EXF72943.1 - 1.1e-24 87.1 40.7 1.3e-24 86.9 40.7 1.1 1 0 0 1 1 1 1 Amino acid permease Sulfotransfer_4 PF17784.1 EXF72944.1 - 1.1e-57 195.3 0.0 1.3e-57 195.1 0.0 1.0 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 EXF72944.1 - 0.15 12.4 0.0 3.9 7.8 0.0 2.2 1 1 0 2 2 2 0 Sulfotransferase family Thioredoxin PF00085.20 EXF72945.1 - 7.5e-23 80.5 0.0 1.2e-22 79.8 0.0 1.3 1 1 0 1 1 1 1 Thioredoxin OST3_OST6 PF04756.13 EXF72945.1 - 3.7e-06 26.5 0.0 6.2e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 EXF72945.1 - 0.00014 22.3 0.6 0.00081 19.8 0.5 2.1 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 EXF72945.1 - 0.0003 21.1 0.0 0.0016 18.7 0.0 1.9 1 1 0 1 1 1 1 Thioredoxin-like Redoxin PF08534.10 EXF72945.1 - 0.00042 20.0 0.1 0.00076 19.2 0.1 1.5 1 1 0 1 1 1 1 Redoxin Thioredoxin_7 PF13899.6 EXF72945.1 - 0.00044 20.4 0.0 0.00079 19.6 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin-like AhpC-TSA PF00578.21 EXF72945.1 - 0.00045 20.1 0.0 0.0028 17.6 0.0 2.0 1 1 0 1 1 1 1 AhpC/TSA family TraF PF13728.6 EXF72945.1 - 0.0025 17.7 0.0 0.0034 17.2 0.0 1.2 1 0 0 1 1 1 1 F plasmid transfer operon protein HyaE PF07449.11 EXF72945.1 - 0.011 15.7 0.0 0.018 15.0 0.0 1.5 1 1 0 1 1 1 0 Hydrogenase-1 expression protein HyaE Thioredoxin_9 PF14595.6 EXF72945.1 - 0.022 14.5 0.0 0.031 14.0 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin Ank_2 PF12796.7 EXF72946.1 - 5.9e-34 116.5 0.4 4.5e-10 40.0 0.2 3.5 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EXF72946.1 - 3.9e-23 81.5 0.1 4.9e-12 46.1 0.0 4.4 2 2 3 5 5 5 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EXF72946.1 - 1.9e-22 79.0 0.7 4.3e-09 36.5 0.0 5.0 2 1 3 5 5 5 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EXF72946.1 - 6e-19 66.2 0.0 0.0058 17.0 0.0 6.4 7 0 0 7 7 7 5 Ankyrin repeat Ank PF00023.30 EXF72946.1 - 1.2e-18 66.7 1.9 0.0032 17.8 0.0 5.8 6 0 0 6 6 6 5 Ankyrin repeat SUB1_ProdP9 PF18213.1 EXF72946.1 - 0.096 12.5 0.0 3.8 7.4 0.0 2.5 2 1 0 2 2 2 0 SUB1 protease Prodomain ProdP9 HET PF06985.11 EXF72947.1 - 1.3e-31 110.0 2.4 1.1e-30 107.0 2.4 2.2 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) MFS_1 PF07690.16 EXF72948.1 - 1.1e-20 73.9 26.4 1.9e-20 73.1 26.4 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily UNC-93 PF05978.16 EXF72948.1 - 2.2e-12 47.0 6.3 2.2e-12 47.0 6.3 3.0 5 0 0 5 5 5 1 Ion channel regulatory protein UNC-93 7TM_GPCR_Sri PF10327.9 EXF72948.1 - 2.6 7.2 6.7 0.12 11.5 1.3 1.6 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Sri Hydantoinase_B PF02538.14 EXF72949.1 - 2.8e-182 606.7 0.6 3.8e-182 606.3 0.6 1.2 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Hydantoinase_A PF01968.18 EXF72949.1 - 6.2e-92 307.9 0.0 1.1e-91 307.1 0.0 1.5 1 0 0 1 1 1 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.13 EXF72949.1 - 4.9e-51 173.0 0.1 2.3e-48 164.3 0.0 2.7 3 0 0 3 3 3 2 Hydantoinase/oxoprolinase N-terminal region RsgI_N PF12791.7 EXF72949.1 - 0.009 15.9 0.1 0.35 10.8 0.1 2.8 3 0 0 3 3 3 1 Anti-sigma factor N-terminus Proteasome_A_N PF10584.9 EXF72949.1 - 0.038 13.7 0.0 0.092 12.4 0.0 1.7 1 0 0 1 1 1 0 Proteasome subunit A N-terminal signature adh_short_C2 PF13561.6 EXF72950.1 - 2.8e-58 197.2 6.2 3.4e-58 197.0 5.7 1.4 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF72950.1 - 1.1e-51 175.1 2.8 1.6e-51 174.6 2.8 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EXF72950.1 - 7.3e-11 42.3 0.4 7.3e-11 42.3 0.4 2.2 2 0 0 2 2 2 1 KR domain Epimerase PF01370.21 EXF72950.1 - 0.009 15.5 0.3 0.018 14.5 0.3 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF1776 PF08643.10 EXF72950.1 - 0.022 14.1 0.0 0.12 11.7 0.0 1.9 2 0 0 2 2 2 0 Fungal family of unknown function (DUF1776) Aldedh PF00171.22 EXF72951.1 - 3.3e-148 494.0 0.0 3.9e-148 493.8 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Jacalin PF01419.17 EXF72953.1 - 0.01 15.8 0.0 0.018 15.0 0.0 1.4 1 0 0 1 1 1 0 Jacalin-like lectin domain RasGEF PF00617.19 EXF72955.1 - 6e-52 176.4 0.0 1.3e-51 175.4 0.0 1.6 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 EXF72955.1 - 1.1e-14 54.5 0.0 3.8e-14 52.8 0.0 1.9 1 0 0 1 1 1 1 RasGEF N-terminal motif SH3_9 PF14604.6 EXF72955.1 - 3e-06 27.0 0.0 5.4e-06 26.2 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EXF72955.1 - 3.6e-05 23.3 0.0 7e-05 22.4 0.0 1.5 1 0 0 1 1 1 1 SH3 domain p450 PF00067.22 EXF72956.1 - 3e-63 214.2 0.0 3.4e-63 214.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF4105 PF13387.6 EXF72957.1 - 0.00048 19.8 0.2 0.00071 19.2 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4105) DUF778 PF05608.12 EXF72957.1 - 0.00055 20.4 0.0 0.001 19.4 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF778) Peptidase_C97 PF05903.14 EXF72957.1 - 0.00076 19.3 0.0 0.0012 18.7 0.0 1.3 1 0 0 1 1 1 1 PPPDE putative peptidase domain LRAT PF04970.13 EXF72957.1 - 0.044 14.1 0.6 0.5 10.7 0.1 2.3 1 1 1 2 2 2 0 Lecithin retinol acyltransferase HET PF06985.11 EXF72961.1 - 5.2e-28 98.2 0.0 1.2e-27 97.0 0.0 1.7 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) TPR_10 PF13374.6 EXF72961.1 - 0.15 12.0 1.3 6.5 6.8 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat MitoNEET_N PF10660.9 EXF72961.1 - 0.19 11.8 0.0 0.58 10.2 0.0 1.8 1 0 0 1 1 1 0 Iron-containing outer mitochondrial membrane protein N-terminus FMO-like PF00743.19 EXF72962.1 - 9e-27 93.7 0.1 1.5e-19 69.9 0.0 3.1 2 1 1 3 3 3 3 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EXF72962.1 - 1.1e-10 41.3 0.1 2.3e-09 36.9 0.1 2.3 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EXF72962.1 - 5.7e-07 29.0 0.1 3.1e-05 23.3 0.0 2.6 2 1 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.14 EXF72962.1 - 1.8e-06 27.5 0.0 1.8e-05 24.1 0.0 2.2 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EXF72962.1 - 0.00032 20.7 0.2 0.0015 18.6 0.2 2.1 1 1 0 1 1 1 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 EXF72962.1 - 0.021 15.0 0.0 0.094 13.0 0.0 2.1 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 EXF72962.1 - 0.14 11.4 0.1 0.34 10.1 0.0 1.6 2 0 0 2 2 2 0 Thi4 family MFS_1 PF07690.16 EXF72963.1 - 7.7e-21 74.4 19.1 3.6e-20 72.2 16.5 2.5 1 1 1 2 2 2 1 Major Facilitator Superfamily MgtC PF02308.16 EXF72963.1 - 0.0055 17.1 1.6 1.5 9.2 0.0 2.7 2 0 0 2 2 2 2 MgtC family CbtA PF09490.10 EXF72963.1 - 0.01 15.6 2.1 1.8 8.2 1.6 2.6 2 0 0 2 2 2 0 Probable cobalt transporter subunit (CbtA) Amino_oxidase PF01593.24 EXF72964.1 - 4.4e-45 154.8 0.1 5.1e-45 154.6 0.1 1.0 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EXF72964.1 - 2.9e-12 46.6 0.3 8.8e-12 45.1 0.3 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 EXF72964.1 - 4.3e-09 36.2 1.4 8.4e-09 35.3 1.4 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EXF72964.1 - 1.7e-08 34.0 3.5 2.8e-08 33.3 3.5 1.3 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 EXF72964.1 - 1.5e-07 31.3 0.5 2.7e-07 30.5 0.5 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 EXF72964.1 - 7.6e-07 28.6 0.5 1.3e-06 27.9 0.5 1.3 1 0 0 1 1 1 1 Thi4 family HI0933_like PF03486.14 EXF72964.1 - 1.9e-06 26.9 0.5 2.7e-06 26.4 0.1 1.5 2 0 0 2 2 2 1 HI0933-like protein GIDA PF01134.22 EXF72964.1 - 3.5e-06 26.3 0.1 5.9e-06 25.6 0.1 1.4 1 0 0 1 1 1 1 Glucose inhibited division protein A Pyr_redox_2 PF07992.14 EXF72964.1 - 1.2e-05 24.7 0.8 1.9e-05 24.1 0.8 1.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EXF72964.1 - 1.5e-05 25.5 0.6 0.00022 21.7 0.3 2.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EXF72964.1 - 0.00017 21.0 0.7 0.005 16.1 0.1 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EXF72964.1 - 0.00045 19.4 1.1 0.0018 17.4 1.0 1.8 2 0 0 2 2 2 1 Lycopene cyclase protein AlaDh_PNT_C PF01262.21 EXF72964.1 - 0.0014 17.9 0.5 0.0028 17.0 0.5 1.5 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_3 PF01494.19 EXF72964.1 - 0.0023 17.2 0.5 0.0054 16.0 0.5 1.6 1 0 0 1 1 1 1 FAD binding domain 3HCDH_N PF02737.18 EXF72964.1 - 0.088 12.7 0.3 0.18 11.7 0.3 1.6 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain PAH PF02671.21 EXF72965.1 - 9.3e-06 25.7 0.0 2.1e-05 24.6 0.0 1.6 1 1 0 1 1 1 1 Paired amphipathic helix repeat Fungal_trans_2 PF11951.8 EXF72966.1 - 1.4e-15 57.0 0.0 5.3e-12 45.3 0.1 2.0 1 1 1 2 2 2 2 Fungal specific transcription factor domain DUF2183 PF09949.9 EXF72968.1 - 2e-33 114.7 0.1 1.5e-32 111.9 0.0 2.4 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2183) Lactamase_B_2 PF12706.7 EXF72969.1 - 4.6e-11 42.6 0.0 7e-11 42.0 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 EXF72969.1 - 5.4e-06 26.4 0.0 8.6e-06 25.7 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Sugar_tr PF00083.24 EXF72970.1 - 8.6e-92 308.3 22.1 9.9e-92 308.1 22.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF72970.1 - 5.7e-21 74.8 38.6 3.6e-14 52.5 15.8 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Romo1 PF10247.9 EXF72970.1 - 0.14 12.5 3.1 6.1 7.3 0.0 3.2 3 0 0 3 3 3 0 Reactive mitochondrial oxygen species modulator 1 OATP PF03137.20 EXF72970.1 - 3.4 5.9 15.2 0.096 10.9 1.8 3.1 2 1 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family ADH_zinc_N PF00107.26 EXF72971.1 - 1e-21 77.2 0.8 1e-21 77.2 0.8 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EXF72971.1 - 1.1e-19 70.4 2.2 1.2e-18 67.0 1.1 2.6 2 1 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 EXF72971.1 - 3e-09 38.0 0.0 7.1e-09 36.8 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EXF72971.1 - 8.7e-08 31.9 1.7 1.3e-07 31.3 1.7 1.2 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus UDPG_MGDP_dh_N PF03721.14 EXF72971.1 - 5.3e-05 22.9 0.1 0.00014 21.5 0.0 1.8 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain AlaDh_PNT_C PF01262.21 EXF72971.1 - 8.4e-05 22.0 4.1 0.00018 20.8 4.0 1.6 1 1 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_2 PF03446.15 EXF72971.1 - 0.00018 21.7 0.2 0.00032 20.9 0.2 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Methyltransf_11 PF08241.12 EXF72971.1 - 0.0063 17.1 0.2 0.018 15.7 0.2 1.9 1 1 0 1 1 1 1 Methyltransferase domain 3HCDH_N PF02737.18 EXF72971.1 - 0.01 15.7 0.5 0.017 15.0 0.5 1.6 1 1 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 EXF72971.1 - 0.015 14.7 0.1 0.023 14.1 0.1 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Methyltransf_25 PF13649.6 EXF72971.1 - 0.053 14.2 0.1 0.17 12.6 0.1 1.9 1 1 0 1 1 1 0 Methyltransferase domain Porphobil_deamC PF03900.15 EXF72971.1 - 0.097 13.1 0.1 14 6.1 0.1 2.5 2 0 0 2 2 2 0 Porphobilinogen deaminase, C-terminal domain HET PF06985.11 EXF72973.1 - 1.2e-23 84.1 0.0 2e-22 80.1 0.0 2.7 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) adh_short_C2 PF13561.6 EXF72974.1 - 9.8e-49 166.0 0.1 1.3e-48 165.6 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF72974.1 - 9.9e-42 142.6 0.1 1.3e-41 142.3 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EXF72974.1 - 1.3e-15 57.8 0.2 2e-15 57.2 0.2 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EXF72974.1 - 0.014 14.8 0.0 0.022 14.2 0.1 1.3 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EXF72974.1 - 0.024 14.0 0.0 0.032 13.6 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Sugar_tr PF00083.24 EXF72975.1 - 5.7e-79 266.1 24.6 7e-79 265.8 24.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF72975.1 - 8.1e-25 87.5 31.3 1.3e-19 70.3 16.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 EXF72975.1 - 0.0055 15.0 0.4 0.0055 15.0 0.4 2.5 2 1 1 3 3 3 1 Organic Anion Transporter Polypeptide (OATP) family adh_short_C2 PF13561.6 EXF72977.1 - 1.4e-43 149.1 0.0 1.3e-38 132.8 0.0 2.1 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF72977.1 - 1.7e-43 148.4 0.0 2.1e-43 148.1 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EXF72977.1 - 1.2e-13 51.4 0.0 1.8e-13 50.8 0.0 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EXF72977.1 - 0.00015 21.4 0.0 0.00047 19.7 0.0 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EXF72977.1 - 0.0054 16.2 0.0 0.029 13.8 0.0 2.1 2 1 0 2 2 2 1 GDP-mannose 4,6 dehydratase DFP PF04127.15 EXF72977.1 - 0.023 14.6 0.2 2.1 8.2 0.2 2.2 1 1 1 2 2 2 0 DNA / pantothenate metabolism flavoprotein 3HCDH_N PF02737.18 EXF72977.1 - 0.028 14.3 0.0 0.053 13.4 0.0 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain YAcAr PF10686.9 EXF72977.1 - 0.028 14.4 0.0 0.9 9.5 0.0 2.4 2 0 0 2 2 2 0 YspA, cpYpsA-related SLOG family DUF1776 PF08643.10 EXF72977.1 - 0.036 13.4 0.0 0.039 13.3 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) F420_oxidored PF03807.17 EXF72977.1 - 0.053 14.1 0.1 0.11 13.0 0.1 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Polysacc_synt_2 PF02719.15 EXF72977.1 - 0.077 12.1 0.0 0.097 11.8 0.0 1.3 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein Pro_Al_protease PF02983.14 EXF72978.1 - 0.42 10.7 1.8 8.6 6.5 0.2 2.3 2 0 0 2 2 2 0 Alpha-lytic protease prodomain DUF678 PF05077.12 EXF72980.1 - 1 9.5 6.7 0.17 12.0 0.7 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF678) SnoaL PF07366.12 EXF72981.1 - 0.0019 18.0 0.1 0.0033 17.2 0.1 1.4 1 0 0 1 1 1 1 SnoaL-like polyketide cyclase Zn_clus PF00172.18 EXF72982.1 - 5.3e-07 29.6 11.0 1.1e-06 28.7 11.0 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EXF72982.1 - 6.6e-06 25.3 0.0 1.1e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain DSX_dimer PF08828.10 EXF72983.1 - 0.2 11.3 0.1 0.35 10.6 0.1 1.4 1 0 0 1 1 1 0 Doublesex dimerisation domain DUF442 PF04273.13 EXF72984.1 - 0.021 14.9 0.2 0.035 14.2 0.2 1.4 1 0 0 1 1 1 0 Putative phosphatase (DUF442) DUF2733 PF10813.8 EXF72984.1 - 0.23 11.3 0.4 0.86 9.4 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2733) NmrA PF05368.13 EXF72985.1 - 2e-27 96.3 0.0 2.7e-27 95.8 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EXF72985.1 - 6e-12 45.8 0.0 8.3e-12 45.4 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding KR PF08659.10 EXF72985.1 - 0.0011 18.9 0.0 0.0053 16.7 0.0 1.9 2 0 0 2 2 2 1 KR domain Epimerase PF01370.21 EXF72985.1 - 0.0045 16.5 0.0 0.018 14.5 0.0 1.8 1 1 1 2 2 2 1 NAD dependent epimerase/dehydratase family DapB_N PF01113.20 EXF72985.1 - 0.11 12.6 0.0 0.26 11.4 0.0 1.6 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Sporozoite_P67 PF05642.11 EXF72988.1 - 7.9 4.4 9.7 11 4.0 9.7 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF4246 PF14033.6 EXF72989.1 - 2.6e-131 438.9 0.0 2.7e-86 290.5 0.0 2.0 1 1 1 2 2 2 2 Protein of unknown function (DUF4246) APH PF01636.23 EXF72990.1 - 3.4e-10 40.2 1.1 3.3e-09 37.0 1.1 2.1 1 1 0 1 1 1 1 Phosphotransferase enzyme family MFS_1 PF07690.16 EXF72991.1 - 2.8e-26 92.3 25.8 2.8e-26 92.3 25.8 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily Tmemb_18A PF09771.9 EXF72991.1 - 0.11 12.9 0.1 3.5 8.0 0.0 2.8 2 0 0 2 2 2 0 Transmembrane protein 188 MAGI_u1 PF16663.5 EXF72991.1 - 0.22 11.6 0.0 0.39 10.8 0.0 1.3 1 0 0 1 1 1 0 Unstructured region on MAGI DUF3292 PF11696.8 EXF72992.1 - 1e-287 955.9 0.0 1e-287 955.9 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF3292) Pex24p PF06398.11 EXF72992.1 - 0.0095 15.0 0.0 0.014 14.4 0.0 1.2 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin Glyco_hydro_32C PF08244.12 EXF72993.1 - 1.5e-30 106.3 0.3 2.4e-30 105.6 0.3 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 C terminal Glyco_hydro_32N PF00251.20 EXF72993.1 - 2.6e-30 106.0 6.9 1e-19 71.3 2.9 2.2 2 0 0 2 2 2 2 Glycosyl hydrolases family 32 N-terminal domain DUF4975 PF16346.5 EXF72993.1 - 0.00013 22.1 0.0 0.00022 21.3 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4975) Ndc1_Nup PF09531.10 EXF72994.1 - 1.2 7.7 3.8 1.9 7.1 3.8 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Sugar_tr PF00083.24 EXF72995.1 - 4.7e-102 342.2 27.3 5.9e-102 341.9 27.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF72995.1 - 2.4e-23 82.6 27.5 2.4e-23 82.6 27.5 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF983 PF06170.12 EXF72995.1 - 1.3 9.5 7.2 0.25 11.8 1.9 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF983) GMC_oxred_N PF00732.19 EXF72998.1 - 1.5e-51 175.6 0.0 4.8e-51 173.9 0.0 1.7 2 0 0 2 2 2 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EXF72998.1 - 8.2e-31 107.5 0.1 1.3e-30 106.9 0.1 1.3 1 0 0 1 1 1 1 GMC oxidoreductase Lycopene_cycl PF05834.12 EXF72998.1 - 0.00011 21.4 0.2 0.00021 20.5 0.2 1.4 1 0 0 1 1 1 1 Lycopene cyclase protein GIDA PF01134.22 EXF72998.1 - 0.00023 20.4 0.0 0.11 11.5 0.0 2.1 2 0 0 2 2 2 2 Glucose inhibited division protein A Pyr_redox_2 PF07992.14 EXF72998.1 - 0.053 12.7 0.0 0.11 11.7 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EXF72998.1 - 0.065 13.5 0.0 0.19 12.0 0.0 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Glyco_hydro_7 PF00840.20 EXF72999.1 - 2.1e-140 468.3 13.6 2.6e-140 468.0 13.6 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 7 HET PF06985.11 EXF73000.1 - 1.9e-25 90.0 0.3 1.4e-24 87.1 0.1 2.5 2 1 0 2 2 2 1 Heterokaryon incompatibility protein (HET) FA_desaturase PF00487.24 EXF73001.1 - 5.4e-32 111.6 19.1 7.8e-32 111.1 19.1 1.2 1 0 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.28 EXF73001.1 - 1.2e-09 38.2 0.0 2.5e-09 37.2 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Ribosomal_S8e PF01201.22 EXF73002.1 - 0.0002 21.5 9.7 0.001 19.3 9.7 2.1 1 1 0 1 1 1 1 Ribosomal protein S8e Bud13 PF09736.9 EXF73002.1 - 1.5 9.2 16.1 2.5 8.5 16.1 1.5 1 1 0 1 1 1 0 Pre-mRNA-splicing factor of RES complex Pannexin_like PF12534.8 EXF73002.1 - 4.5 6.3 7.3 7.1 5.6 7.3 1.3 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 Red1 PF07964.11 EXF73002.1 - 4.9 5.3 13.3 5.9 5.0 13.3 1.0 1 0 0 1 1 1 0 Rec10 / Red1 Ribosomal_L21p PF00829.21 EXF73003.1 - 1e-10 41.7 0.0 1.5e-10 41.2 0.0 1.2 1 0 0 1 1 1 1 Ribosomal prokaryotic L21 protein Pkinase PF00069.25 EXF73004.1 - 3.7e-46 157.6 0.0 5.5e-46 157.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF73004.1 - 2.8e-19 69.4 0.0 4.3e-19 68.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EXF73004.1 - 0.0036 17.3 0.0 0.66 9.8 0.0 2.6 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.6 EXF73004.1 - 0.032 13.5 0.0 0.097 12.0 0.0 1.7 2 0 0 2 2 2 0 Kinase-like RIO1 PF01163.22 EXF73004.1 - 0.11 12.0 0.0 0.25 10.9 0.0 1.6 1 0 0 1 1 1 0 RIO1 family Ribosomal_60s PF00428.19 EXF73005.1 - 1e-26 93.3 11.0 1.2e-26 93.1 11.0 1.0 1 0 0 1 1 1 1 60s Acidic ribosomal protein EF-hand_14 PF17959.1 EXF73005.1 - 0.01 16.2 0.0 0.015 15.7 0.0 1.3 1 0 0 1 1 1 0 EF-hand domain UBA_6 PF18039.1 EXF73005.1 - 0.11 12.4 0.7 0.2 11.6 0.1 1.6 2 0 0 2 2 2 0 UBA-like domain SPT2 PF08243.11 EXF73006.1 - 3.1e-06 27.7 30.3 3.1e-06 27.7 30.3 3.3 3 1 0 3 3 3 1 SPT2 chromatin protein NUFIP1 PF10453.9 EXF73007.1 - 8e-07 28.8 1.0 1.7e-06 27.8 0.0 2.0 2 0 0 2 2 2 1 Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) zf_CCCH_4 PF18345.1 EXF73007.1 - 0.039 14.0 6.8 0.072 13.2 6.8 1.5 1 0 0 1 1 1 0 Zinc finger domain zf-CCCH PF00642.24 EXF73007.1 - 0.19 11.7 5.9 0.45 10.5 5.9 1.6 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) MCM3AP_GANP PF16769.5 EXF73007.1 - 0.81 7.9 4.9 1.2 7.3 4.9 1.1 1 0 0 1 1 1 0 MCM3AP domain of GANP RNA_pol_Rbc25 PF08292.12 EXF73008.1 - 3.1e-32 111.5 1.7 2e-31 108.9 1.7 2.0 1 1 0 1 1 1 1 RNA polymerase III subunit Rpc25 SHS2_Rpb7-N PF03876.17 EXF73008.1 - 7.6e-15 55.0 0.0 1.2e-14 54.4 0.0 1.3 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 EMC3_TMCO1 PF01956.16 EXF73009.1 - 2.2e-52 177.2 0.8 2.7e-52 176.9 0.8 1.1 1 0 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like SPC25 PF06703.11 EXF73010.1 - 8.5e-54 181.7 0.1 1e-53 181.5 0.1 1.1 1 0 0 1 1 1 1 Microsomal signal peptidase 25 kDa subunit (SPC25) MMS19_N PF14500.6 EXF73011.1 - 1.7e-58 198.3 0.1 6.1e-58 196.5 0.0 2.0 2 0 0 2 2 2 1 Dos2-interacting transcription regulator of RNA-Pol-II DCB PF16213.5 EXF73011.1 - 0.098 12.3 0.0 2.3 7.9 0.0 2.7 2 0 0 2 2 2 0 Dimerisation and cyclophilin-binding domain of Mon2 THF_DHG_CYH PF00763.23 EXF73012.1 - 1.6e-26 92.9 0.1 2.5e-26 92.2 0.1 1.3 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain THF_DHG_CYH_C PF02882.19 EXF73012.1 - 3.9e-15 55.5 0.0 9.6e-09 34.8 0.0 2.4 2 0 0 2 2 2 2 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Erythro-docking PF09277.11 EXF73013.1 - 1.7 8.6 5.1 2.3 8.2 0.5 3.0 2 0 0 2 2 2 0 Erythronolide synthase, docking DUF1765 PF08578.10 EXF73014.1 - 2.9e-45 153.8 2.3 6.8e-45 152.6 2.3 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1765) SBF PF01758.16 EXF73016.1 - 8.4e-47 159.4 15.2 8.4e-47 159.4 15.2 2.1 2 1 1 3 3 3 1 Sodium Bile acid symporter family F-box-like PF12937.7 EXF73017.1 - 0.058 13.3 1.0 0.14 12.0 0.5 2.0 2 0 0 2 2 2 0 F-box-like Cys_Met_Meta_PP PF01053.20 EXF73018.1 - 3.8e-140 466.8 0.1 4.4e-140 466.6 0.1 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 EXF73018.1 - 7.3e-08 31.8 0.5 1.5e-07 30.7 0.5 1.4 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 EXF73018.1 - 1.8e-07 30.6 0.2 2.9e-07 30.0 0.2 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 EXF73018.1 - 5.2e-06 26.0 1.0 8.9e-06 25.2 1.0 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family GDC-P PF02347.16 EXF73018.1 - 0.013 14.4 0.5 0.021 13.7 0.5 1.2 1 0 0 1 1 1 0 Glycine cleavage system P-protein 2-Hacid_dh PF00389.30 EXF73018.1 - 0.061 13.0 0.3 0.11 12.1 0.1 1.4 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain EST1_DNA_bind PF10373.9 EXF73019.1 - 1.4e-09 37.9 0.7 3.3e-09 36.6 0.7 1.7 1 0 0 1 1 1 1 Est1 DNA/RNA binding domain zf-C2H2_2 PF12756.7 EXF73019.1 - 0.15 12.4 0.9 0.78 10.1 0.2 2.4 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) DUF5022 PF16425.5 EXF73020.1 - 0.026 14.0 0.0 0.056 12.9 0.0 1.4 2 0 0 2 2 2 0 Domain of unknown function (DUF5022) F-box-like PF12937.7 EXF73020.1 - 0.03 14.2 0.7 0.03 14.2 0.7 1.9 2 0 0 2 2 2 0 F-box-like TPR_16 PF13432.6 EXF73021.1 - 1.7e-05 25.4 3.9 2.5e-05 24.8 0.4 2.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_21 PF09976.9 EXF73021.1 - 3e-05 23.8 0.8 3e-05 23.8 0.8 1.9 3 0 0 3 3 3 1 Tetratricopeptide repeat-like domain TPR_8 PF13181.6 EXF73021.1 - 0.001 19.1 1.2 0.0045 17.1 0.2 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat Luciferase_N PF05295.11 EXF73021.1 - 0.019 15.0 0.2 3.2 7.9 0.1 2.5 2 0 0 2 2 2 0 Luciferase/LBP N-terminal domain TPR_2 PF07719.17 EXF73021.1 - 0.026 14.6 3.2 0.33 11.2 0.2 3.9 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_7 PF13176.6 EXF73021.1 - 0.026 14.5 1.8 1.9 8.7 0.1 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 EXF73021.1 - 0.032 14.7 2.7 0.22 12.1 0.2 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 EXF73021.1 - 0.041 13.7 1.4 0.44 10.5 0.1 3.3 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_10 PF13374.6 EXF73021.1 - 0.057 13.3 3.3 3.1 7.8 0.1 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 EXF73021.1 - 0.18 12.7 4.2 0.95 10.5 0.1 3.7 4 1 1 5 5 5 0 Tetratricopeptide repeat DUF3295 PF11702.8 EXF73022.1 - 7.3e-21 75.1 1.2 9.4e-21 74.7 1.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3295) DUF3425 PF11905.8 EXF73023.1 - 0.00033 20.6 1.6 0.00033 20.6 1.6 2.1 2 1 1 3 3 3 1 Domain of unknown function (DUF3425) Methyltransf_23 PF13489.6 EXF73026.1 - 1.5e-10 41.2 0.0 4e-10 39.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF73026.1 - 2.4e-06 27.4 0.0 0.0011 18.8 0.0 2.5 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_25 PF13649.6 EXF73026.1 - 8.1e-05 23.3 0.0 0.00065 20.3 0.0 2.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF73026.1 - 0.00011 22.7 0.0 0.0008 20.0 0.0 2.4 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF73026.1 - 0.00043 21.0 0.0 0.0028 18.3 0.0 2.5 2 1 0 2 2 2 1 Methyltransferase domain His_Phos_1 PF00300.22 EXF73027.1 - 1.9e-27 96.2 0.0 3.6e-27 95.3 0.0 1.4 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) CFAP91 PF14738.6 EXF73027.1 - 0.099 12.7 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 Cilia- and flagella-associated protein 91 Ank_2 PF12796.7 EXF73028.1 - 1.5e-15 57.6 1.5 1.5e-05 25.5 0.1 3.6 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EXF73028.1 - 4e-11 43.2 0.1 5.4e-05 23.7 0.0 3.8 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EXF73028.1 - 4.1e-09 35.9 0.2 1 10.2 0.0 5.7 5 0 0 5 5 5 3 Ankyrin repeat Ank PF00023.30 EXF73028.1 - 1e-07 32.1 0.3 0.19 12.2 0.0 4.9 5 0 0 5 5 5 2 Ankyrin repeat Ank_5 PF13857.6 EXF73028.1 - 6.3e-05 23.2 0.3 0.012 15.9 0.0 3.4 2 2 1 3 3 3 2 Ankyrin repeats (many copies) APC1_C PF18122.1 EXF73028.1 - 0.15 12.0 0.0 0.71 9.8 0.0 2.1 3 0 0 3 3 3 0 Anaphase-promoting complex sub unit 1 C-terminal domain DUF1771 PF08590.10 EXF73029.1 - 1.9e-24 85.8 11.8 4.6e-24 84.6 11.8 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1771) Smr PF01713.21 EXF73029.1 - 3.6e-09 36.8 1.1 6.7e-09 36.0 0.3 2.0 2 0 0 2 2 2 1 Smr domain DUF4407 PF14362.6 EXF73029.1 - 0.22 10.9 4.0 0.34 10.2 4.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) OmpH PF03938.14 EXF73029.1 - 0.3 11.4 10.2 0.87 9.9 3.6 2.3 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) DUF4175 PF13779.6 EXF73029.1 - 5 4.9 23.3 0.2 9.5 4.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4175) zf-Tim10_DDP PF02953.15 EXF73030.1 - 1.6e-18 66.1 5.4 2.6e-18 65.4 5.4 1.3 1 0 0 1 1 1 1 Tim10/DDP family zinc finger UPF0137 PF03677.13 EXF73030.1 - 0.043 13.6 1.2 0.051 13.4 1.2 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0137) Nup188_C PF18378.1 EXF73031.1 - 4.1e-156 519.5 0.0 6.3e-156 518.9 0.0 1.3 1 0 0 1 1 1 1 Nuclear pore protein NUP188 C-terminal domain Nup188 PF10487.9 EXF73031.1 - 1.8e-60 205.0 0.0 6.5e-45 153.5 0.0 2.6 2 1 0 2 2 2 2 Nucleoporin subcomplex protein binding to Pom34 IGPS PF00218.21 EXF73032.1 - 3.7e-96 321.2 0.1 5.5e-96 320.6 0.1 1.3 1 0 0 1 1 1 1 Indole-3-glycerol phosphate synthase PRAI PF00697.22 EXF73032.1 - 6.9e-52 176.1 0.1 3.9e-46 157.3 0.0 2.5 1 1 1 2 2 2 2 N-(5'phosphoribosyl)anthranilate (PRA) isomerase GATase PF00117.28 EXF73032.1 - 1.6e-45 155.3 0.0 4.3e-45 153.8 0.0 1.7 2 0 0 2 2 2 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 EXF73032.1 - 0.00018 21.3 0.3 0.0015 18.3 0.3 2.4 1 1 0 1 1 1 1 Peptidase C26 NanE PF04131.14 EXF73032.1 - 0.0039 16.4 0.0 0.93 8.7 0.0 3.2 3 0 0 3 3 3 1 Putative N-acetylmannosamine-6-phosphate epimerase FMN_dh PF01070.18 EXF73032.1 - 0.025 13.6 0.1 0.17 10.9 0.0 2.2 2 0 0 2 2 2 0 FMN-dependent dehydrogenase QRPTase_C PF01729.19 EXF73032.1 - 0.043 13.6 0.7 1.4 8.7 0.1 2.6 2 0 0 2 2 2 0 Quinolinate phosphoribosyl transferase, C-terminal domain Malate_DH PF12434.8 EXF73032.1 - 0.069 13.2 0.1 0.22 11.6 0.1 1.9 1 0 0 1 1 1 0 Malate dehydrogenase enzyme BRCT PF00533.26 EXF73033.1 - 0.00045 20.6 0.3 0.0011 19.3 0.3 1.7 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EXF73033.1 - 0.0019 18.6 0.1 0.0041 17.5 0.1 1.5 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain CALM_bind PF16025.5 EXF73033.1 - 0.015 15.8 1.4 0.047 14.2 1.4 1.8 1 0 0 1 1 1 0 Calcium-dependent calmodulin binding SKG6 PF08693.10 EXF73034.1 - 0.001 18.4 5.9 0.0017 17.7 5.9 1.3 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Herpes_gE PF02480.16 EXF73034.1 - 0.0081 14.9 0.0 0.012 14.4 0.0 1.2 1 0 0 1 1 1 1 Alphaherpesvirus glycoprotein E CEND1 PF15677.5 EXF73034.1 - 0.012 16.2 0.9 0.03 14.9 0.2 2.0 2 0 0 2 2 2 0 Cell cycle exit and neuronal differentiation protein 1 DUF4328 PF14219.6 EXF73034.1 - 0.033 13.7 0.0 0.048 13.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4328) Syndecan PF01034.20 EXF73034.1 - 0.036 14.0 0.0 0.058 13.3 0.0 1.3 1 0 0 1 1 1 0 Syndecan domain Adeno_E3_CR2 PF02439.15 EXF73034.1 - 0.04 13.7 0.2 0.075 12.8 0.2 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 EphA2_TM PF14575.6 EXF73034.1 - 0.057 14.3 0.0 0.11 13.4 0.0 1.4 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF3827 PF12877.7 EXF73034.1 - 0.12 10.7 0.0 0.17 10.2 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) MaoC_dehydratas PF01575.19 EXF73036.1 - 4.7e-07 29.4 0.0 7.4e-07 28.8 0.0 1.3 1 0 0 1 1 1 1 MaoC like domain MaoC_dehydrat_N PF13452.6 EXF73036.1 - 0.011 15.8 0.0 4.3 7.5 0.0 2.8 3 0 0 3 3 3 0 N-terminal half of MaoC dehydratase eRF1_2 PF03464.15 EXF73037.1 - 3.8e-46 156.7 0.0 6.3e-46 156.0 0.0 1.4 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 EXF73037.1 - 3e-40 137.2 0.7 5.9e-40 136.3 0.7 1.5 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_1 PF03463.15 EXF73037.1 - 7.7e-22 77.7 0.0 1.2e-21 77.0 0.0 1.3 1 0 0 1 1 1 1 eRF1 domain 1 baeRF_family10 PF18854.1 EXF73037.1 - 6.2e-11 42.7 0.3 2.9e-10 40.5 0.0 2.0 2 0 0 2 2 2 1 Bacterial archaeo-eukaryotic release factor family 10 acVLRF1 PF18859.1 EXF73037.1 - 9.4e-10 38.9 0.0 1.5e-09 38.2 0.0 1.3 1 0 0 1 1 1 1 Actinobacteria/chloroflexi VLRF1 release factor DUF1770 PF08589.10 EXF73038.1 - 3.5e-36 124.2 1.3 4.6e-36 123.7 1.3 1.2 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1770) Nop14 PF04147.12 EXF73039.1 - 0.34 9.1 8.2 0.43 8.7 8.2 1.2 1 0 0 1 1 1 0 Nop14-like family ORC6 PF05460.13 EXF73039.1 - 1.6 8.0 5.8 3.1 7.0 5.8 1.6 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Ribosomal_L2_C PF03947.18 EXF73040.1 - 7.6e-42 142.5 4.9 1.3e-41 141.7 4.9 1.4 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 EXF73040.1 - 1.9e-15 56.5 0.1 4.5e-15 55.4 0.1 1.7 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain PfkB PF00294.24 EXF73041.1 - 3.5e-66 223.6 0.1 4e-66 223.4 0.1 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.12 EXF73041.1 - 0.11 11.9 0.0 0.19 11.1 0.0 1.4 1 0 0 1 1 1 0 Phosphomethylpyrimidine kinase EST1_DNA_bind PF10373.9 EXF73042.1 - 1.4e-49 169.1 0.2 2.7e-49 168.2 0.2 1.5 1 0 0 1 1 1 1 Est1 DNA/RNA binding domain EST1 PF10374.9 EXF73042.1 - 2.6e-20 73.4 1.3 5e-20 72.5 0.3 2.1 2 0 0 2 2 2 1 Telomerase activating protein Est1 XPA_N PF01286.18 EXF73043.1 - 0.063 13.3 0.4 0.24 11.5 0.4 2.0 1 1 1 2 2 2 0 XPA protein N-terminal zf-C2H2_11 PF16622.5 EXF73043.1 - 0.33 10.8 2.2 0.72 9.7 2.2 1.6 1 0 0 1 1 1 0 zinc-finger C2H2-type G10 PF01125.17 EXF73044.1 - 1.1e-63 213.4 4.0 1.2e-63 213.2 4.0 1.0 1 0 0 1 1 1 1 G10 protein Complex1_LYR_2 PF13233.6 EXF73045.1 - 2.1e-06 28.4 0.1 2.9e-06 27.9 0.1 1.2 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR PF05347.15 EXF73045.1 - 0.00046 20.2 0.2 0.0011 19.0 0.2 1.6 1 1 0 1 1 1 1 Complex 1 protein (LYR family) RNA_pol_L_2 PF13656.6 EXF73046.1 - 2.6e-30 104.0 0.0 3.2e-30 103.7 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 EXF73046.1 - 2.1e-11 43.1 0.0 3e-11 42.6 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Acetyltransf_3 PF13302.7 EXF73047.1 - 9.1e-15 55.5 0.1 3.7e-14 53.6 0.1 1.8 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EXF73047.1 - 3.1e-06 27.4 0.3 4.7e-06 26.8 0.3 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Secretin_N_2 PF07655.13 EXF73047.1 - 0.088 13.4 3.4 0.14 12.7 3.4 1.4 1 0 0 1 1 1 0 Secretin N-terminal domain TPR_1 PF00515.28 EXF73050.1 - 4.5e-07 29.4 12.1 0.013 15.3 0.5 3.8 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 EXF73050.1 - 4.6e-07 29.5 7.4 0.25 11.5 0.2 3.9 3 0 0 3 3 3 3 Tetratricopeptide repeat ANAPC3 PF12895.7 EXF73050.1 - 0.0031 17.7 1.4 0.0092 16.2 1.4 1.8 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 EXF73050.1 - 0.0085 16.2 3.7 11 6.5 0.3 3.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 EXF73050.1 - 0.051 14.1 1.0 0.051 14.1 1.0 3.5 5 0 0 5 5 5 0 Tetratricopeptide repeat DUF3343 PF11823.8 EXF73050.1 - 0.052 13.0 0.2 0.72 9.4 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3343) TPR_17 PF13431.6 EXF73050.1 - 0.091 13.2 0.7 2 9.0 0.2 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat Pox_T4_N PF04491.12 EXF73050.1 - 0.16 11.8 0.1 2.4 8.1 0.0 2.6 2 0 0 2 2 2 0 Poxvirus T4 protein, N terminus MFS_1 PF07690.16 EXF73051.1 - 5.6e-37 127.5 22.5 1e-28 100.3 2.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF73051.1 - 4.7e-08 32.3 7.8 4.7e-08 32.3 7.8 2.5 2 1 0 2 2 2 1 Sugar (and other) transporter MFS_1_like PF12832.7 EXF73051.1 - 0.023 13.5 13.3 0.14 11.0 4.3 2.7 3 0 0 3 3 3 0 MFS_1 like family BT1 PF03092.16 EXF73051.1 - 0.16 10.2 5.8 2 6.5 0.1 2.2 2 0 0 2 2 2 0 BT1 family NACHT_N PF17100.5 EXF73052.1 - 1.7e-34 119.6 0.4 3.9e-34 118.4 0.4 1.5 1 0 0 1 1 1 1 N-terminal domain of NWD NACHT-NTPase WD40 PF00400.32 EXF73052.1 - 2.8e-22 78.6 19.0 8.4e-09 35.9 0.5 8.1 8 0 0 8 8 8 5 WD domain, G-beta repeat NACHT PF05729.12 EXF73052.1 - 1.8e-12 47.5 0.0 6.1e-12 45.8 0.0 1.9 1 0 0 1 1 1 1 NACHT domain ANAPC4_WD40 PF12894.7 EXF73052.1 - 3.2e-11 43.4 2.6 0.044 14.1 0.0 6.8 4 1 3 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 EXF73052.1 - 2.7e-07 30.3 1.6 4.2 7.4 0.0 5.1 4 0 0 4 4 4 3 WD40-like Beta Propeller Repeat Ge1_WD40 PF16529.5 EXF73052.1 - 0.00039 19.5 0.4 0.34 9.8 0.0 4.4 4 1 0 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Nucleolin_bd PF16725.5 EXF73052.1 - 0.038 13.6 0.1 0.094 12.4 0.1 1.7 1 0 0 1 1 1 0 Nucleolin binding domain AAA_19 PF13245.6 EXF73052.1 - 0.13 12.6 0.0 0.5 10.7 0.0 2.0 1 1 0 1 1 1 0 AAA domain Cas_GSU0053 PF09617.10 EXF73053.1 - 0.032 14.2 0.0 0.084 12.8 0.0 1.7 1 0 0 1 1 1 0 CRISPR-associated protein GSU0053 (Cas_GSU0053) ADH_N PF08240.12 EXF73054.1 - 1.3e-30 105.5 1.0 2.2e-30 104.7 1.0 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EXF73054.1 - 4.5e-16 59.0 0.0 6.9e-16 58.4 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EXF73054.1 - 8.5e-07 28.7 0.0 1.3e-06 28.0 0.0 1.2 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 EXF73054.1 - 0.00026 22.1 0.0 0.00041 21.4 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_assoc PF13823.6 EXF73054.1 - 0.00028 20.7 0.0 0.00059 19.7 0.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-associated AlaDh_PNT_C PF01262.21 EXF73054.1 - 0.005 16.2 0.0 0.024 13.9 0.0 1.9 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain Sen15 PF09631.10 EXF73055.1 - 3.4e-26 91.5 0.0 6e-26 90.7 0.0 1.4 1 1 0 1 1 1 1 Sen15 protein DUF2985 PF11204.8 EXF73056.1 - 1.1e-38 131.3 1.4 1.1e-38 131.3 1.4 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF2985) Nuc_sug_transp PF04142.15 EXF73057.1 - 3.6e-10 39.5 1.4 1.2e-09 37.8 1.4 1.8 1 1 0 1 1 1 1 Nucleotide-sugar transporter EamA PF00892.20 EXF73057.1 - 4.1e-09 36.7 24.1 0.00019 21.6 5.4 2.5 2 1 0 2 2 2 2 EamA-like transporter family TPT PF03151.16 EXF73057.1 - 3.3e-05 23.4 1.6 3.3e-05 23.4 1.6 1.8 2 0 0 2 2 2 1 Triose-phosphate Transporter family PUNUT PF16913.5 EXF73057.1 - 0.00083 18.7 0.7 0.00083 18.7 0.7 1.7 2 0 0 2 2 2 1 Purine nucleobase transmembrane transport DUF2975 PF11188.8 EXF73057.1 - 0.14 12.1 11.9 0.69 9.8 0.9 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2975) CRT-like PF08627.10 EXF73057.1 - 0.37 9.7 8.6 0.078 11.9 5.0 1.6 2 0 0 2 2 2 0 CRT-like, chloroquine-resistance transporter-like DUF423 PF04241.15 EXF73057.1 - 0.68 10.2 6.1 3.7 7.8 0.9 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF423) Gate PF07670.14 EXF73057.1 - 1.8 8.9 10.1 0.12 12.6 1.9 2.9 3 1 0 3 3 3 0 Nucleoside recognition Yippee-Mis18 PF03226.14 EXF73058.1 - 4.9e-17 62.0 0.8 5.5e-17 61.9 0.8 1.0 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly RIG-I_C-RD PF11648.8 EXF73058.1 - 0.0028 17.9 1.5 0.0039 17.4 1.5 1.3 1 0 0 1 1 1 1 C-terminal domain of RIG-I DUF2039 PF10217.9 EXF73058.1 - 0.013 15.9 1.8 0.051 13.9 0.1 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2039) HNH_5 PF14279.6 EXF73058.1 - 0.048 13.5 1.6 0.52 10.2 0.1 2.2 2 0 0 2 2 2 0 HNH endonuclease Ferric_reduct PF01794.19 EXF73059.1 - 1.4e-24 86.6 9.0 3.5e-24 85.3 9.0 1.7 1 0 0 1 1 1 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 EXF73059.1 - 2.3e-19 70.0 0.0 1.4e-16 61.0 0.0 2.4 1 1 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EXF73059.1 - 1e-12 48.1 0.0 1.1e-08 35.1 0.0 2.4 2 0 0 2 2 2 2 FAD-binding domain DUF1345 PF07077.11 EXF73059.1 - 0.2 11.3 8.4 0.085 12.5 4.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1345) CLU PF13236.6 EXF73061.1 - 3.9e-77 259.0 0.0 6.8e-77 258.2 0.0 1.4 1 0 0 1 1 1 1 Clustered mitochondria eIF3_p135 PF12807.7 EXF73061.1 - 7.5e-53 179.2 0.0 7.5e-53 179.2 0.0 2.3 2 0 0 2 2 2 1 Translation initiation factor eIF3 subunit 135 TPR_12 PF13424.6 EXF73061.1 - 7.4e-24 83.9 11.5 2.5e-10 40.5 0.1 4.1 3 1 1 4 4 4 3 Tetratricopeptide repeat CLU_N PF15044.6 EXF73061.1 - 1.1e-23 83.3 0.5 3.5e-23 81.7 0.0 2.1 2 0 0 2 2 2 1 Mitochondrial function, CLU-N-term TPR_10 PF13374.6 EXF73061.1 - 1.3e-22 78.9 0.5 7.2e-06 25.7 0.0 5.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 EXF73061.1 - 0.00046 20.2 6.8 0.016 15.4 0.2 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.17 EXF73061.1 - 0.002 18.1 6.5 0.1 12.8 0.1 4.5 4 0 0 4 4 4 1 Tetratricopeptide repeat DUF727 PF05303.12 EXF73061.1 - 0.0071 16.4 0.0 0.023 14.8 0.0 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF727) DDHD PF02862.17 EXF73061.1 - 0.008 16.4 3.1 0.008 16.4 3.1 1.9 2 0 0 2 2 2 1 DDHD domain AF-4 PF05110.13 EXF73061.1 - 0.12 10.5 19.9 0.25 9.4 19.9 1.4 1 0 0 1 1 1 0 AF-4 proto-oncoprotein CDC45 PF02724.14 EXF73061.1 - 0.13 10.6 15.1 0.2 9.9 15.1 1.2 1 0 0 1 1 1 0 CDC45-like protein TPR_MalT PF17874.1 EXF73061.1 - 0.35 10.2 5.1 1.3 8.3 0.1 2.2 1 1 0 2 2 2 0 MalT-like TPR region Nop14 PF04147.12 EXF73061.1 - 2.4 6.2 24.5 4.9 5.2 24.5 1.4 1 0 0 1 1 1 0 Nop14-like family NOA36 PF06524.12 EXF73061.1 - 2.9 7.1 15.7 5.6 6.2 15.7 1.4 1 0 0 1 1 1 0 NOA36 protein SDA1 PF05285.12 EXF73061.1 - 3.4 7.0 28.4 9.9 5.5 28.4 1.7 1 0 0 1 1 1 0 SDA1 NPR3 PF03666.13 EXF73061.1 - 4.8 5.9 15.5 8.5 5.0 15.5 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 SAPS PF04499.15 EXF73061.1 - 5.6 5.6 10.3 11 4.7 10.3 1.4 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DUF913 PF06025.12 EXF73061.1 - 8.8 5.2 10.1 21 4.0 10.1 1.6 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Forkhead PF00250.18 EXF73062.1 - 5.9e-35 119.4 1.0 1.4e-34 118.2 0.8 1.7 2 0 0 2 2 2 1 Forkhead domain FHA PF00498.26 EXF73062.1 - 1.1e-08 35.3 0.0 2.8e-08 34.0 0.0 1.8 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 EXF73062.1 - 0.00046 20.4 0.0 0.00085 19.6 0.0 1.4 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain Linker_histone PF00538.19 EXF73062.1 - 0.067 13.6 0.2 0.16 12.3 0.2 1.6 1 0 0 1 1 1 0 linker histone H1 and H5 family Tubulin_3 PF14881.6 EXF73063.1 - 2.8e-78 261.7 0.2 4.9e-78 260.9 0.2 1.4 1 0 0 1 1 1 1 Tubulin domain Misat_Tub_SegII PF10644.9 EXF73063.1 - 9.8e-42 142.0 0.1 1.6e-41 141.3 0.1 1.4 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin PF00091.25 EXF73063.1 - 1.6e-06 28.4 0.0 0.0045 17.2 0.0 2.4 2 0 0 2 2 2 2 Tubulin/FtsZ family, GTPase domain PAP_central PF04928.17 EXF73064.1 - 1e-106 355.5 0.0 1.4e-106 355.0 0.0 1.2 1 0 0 1 1 1 1 Poly(A) polymerase central domain PAP_RNA-bind PF04926.15 EXF73064.1 - 4.7e-66 221.6 0.9 1.1e-65 220.4 0.9 1.7 1 1 0 1 1 1 1 Poly(A) polymerase predicted RNA binding domain NTP_transf_2 PF01909.23 EXF73064.1 - 5.5e-09 36.2 0.0 1.3e-08 35.0 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyltransferase domain Nrap_D2 PF17403.2 EXF73064.1 - 0.067 13.0 0.2 0.19 11.5 0.1 1.8 2 0 0 2 2 2 0 Nrap protein PAP/OAS-like domain Polbeta PF18765.1 EXF73064.1 - 0.13 12.3 0.0 0.33 11.1 0.0 1.6 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase Septin PF00735.18 EXF73065.1 - 4.9e-19 68.7 0.0 1e-17 64.3 0.0 2.1 1 1 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 EXF73065.1 - 5.4e-05 23.3 0.1 0.29 11.2 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_16 PF13191.6 EXF73065.1 - 0.0091 16.4 0.0 0.025 14.9 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 EXF73065.1 - 0.018 14.9 0.4 0.23 11.3 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase AAA_22 PF13401.6 EXF73065.1 - 0.029 14.6 0.1 0.083 13.2 0.1 1.7 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EXF73065.1 - 0.05 13.3 0.1 0.96 9.1 0.0 2.1 2 0 0 2 2 2 0 AAA domain ATP_bind_1 PF03029.17 EXF73065.1 - 0.069 12.9 0.3 4.2 7.1 0.1 2.2 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein ABC_tran PF00005.27 EXF73065.1 - 0.093 13.2 0.1 0.89 10.1 0.0 2.6 2 1 0 2 2 2 0 ABC transporter Roc PF08477.13 EXF73065.1 - 0.12 12.6 0.0 0.23 11.7 0.0 1.4 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA PF00004.29 EXF73065.1 - 0.16 12.4 0.1 0.3 11.5 0.1 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Viral_helicase1 PF01443.18 EXF73065.1 - 0.17 11.6 0.1 0.36 10.5 0.1 1.5 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Pkinase PF00069.25 EXF73066.1 - 3.9e-78 262.5 0.0 4.6e-78 262.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF73066.1 - 4.4e-38 131.0 0.0 5.8e-38 130.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EXF73066.1 - 0.001 18.1 0.0 0.012 14.6 0.0 2.1 1 1 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EXF73066.1 - 0.0082 15.5 0.1 0.014 14.8 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EXF73066.1 - 0.019 14.9 0.1 0.068 13.1 0.1 1.8 1 1 0 1 1 1 0 Phosphotransferase enzyme family Kinase-like PF14531.6 EXF73066.1 - 0.087 12.1 0.1 0.25 10.6 0.0 1.8 1 1 0 2 2 2 0 Kinase-like Acyltransferase PF01553.21 EXF73067.1 - 1.1e-06 28.3 0.0 1.1e-05 25.1 0.0 2.1 1 1 0 1 1 1 1 Acyltransferase zf-NOSIP PF15906.5 EXF73068.1 - 1.7e-09 37.7 0.1 4.6e-07 29.9 0.0 2.6 2 1 0 2 2 2 1 Zinc-finger of nitric oxide synthase-interacting protein zf-RING_UBOX PF13445.6 EXF73068.1 - 0.0058 16.6 0.4 0.012 15.7 0.4 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EXF73068.1 - 0.012 15.5 2.0 0.023 14.5 2.0 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EXF73068.1 - 0.042 14.2 1.3 0.081 13.3 1.3 1.5 1 0 0 1 1 1 0 Ring finger domain zf-C3HC4_4 PF15227.6 EXF73068.1 - 0.043 14.0 1.7 0.076 13.2 1.7 1.4 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.25 EXF73068.1 - 0.053 13.4 1.8 0.053 13.4 1.8 1.6 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Ima1_N PF09779.9 EXF73068.1 - 0.057 14.3 1.3 0.092 13.6 1.2 1.4 1 1 0 1 1 1 0 Ima1 N-terminal domain TerB_C PF15615.6 EXF73068.1 - 0.1 12.9 7.0 0.32 11.3 0.2 2.2 2 0 0 2 2 2 0 TerB-C domain Mito_carr PF00153.27 EXF73069.1 - 3.9e-42 142.1 0.4 4.9e-14 52.0 0.1 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein SCA7 PF08313.12 EXF73070.1 - 6.7e-32 109.2 0.2 2.4e-31 107.4 0.2 2.0 1 0 0 1 1 1 1 SCA7, zinc-binding domain CDC45 PF02724.14 EXF73070.1 - 0.18 10.1 12.6 0.24 9.6 12.6 1.3 1 0 0 1 1 1 0 CDC45-like protein Lipase_GDSL_2 PF13472.6 EXF73072.1 - 6.4e-10 39.7 0.1 1.7e-08 35.1 0.1 2.3 1 1 0 2 2 2 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EXF73072.1 - 0.0001 22.4 0.0 0.00014 21.9 0.0 1.5 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase zf-C2H2 PF00096.26 EXF73073.1 - 0.0088 16.5 19.8 0.094 13.2 0.8 4.7 4 1 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EXF73073.1 - 0.018 15.8 19.0 0.088 13.7 0.7 5.0 4 1 0 4 4 4 0 C2H2-type zinc finger zf-TRAF PF02176.18 EXF73073.1 - 0.12 13.1 0.8 0.41 11.4 0.8 2.0 1 0 0 1 1 1 0 TRAF-type zinc finger Sina PF03145.16 EXF73073.1 - 1.7 8.5 7.2 0.23 11.4 2.9 1.7 2 0 0 2 2 2 0 Seven in absentia protein family Patatin PF01734.22 EXF73075.1 - 1.9e-15 57.6 0.0 6.2e-15 55.9 0.0 1.9 1 1 0 1 1 1 1 Patatin-like phospholipase Fungal_trans_2 PF11951.8 EXF73076.1 - 4.1e-11 42.3 0.0 3.4e-10 39.3 0.0 2.0 2 0 0 2 2 2 1 Fungal specific transcription factor domain MatE PF01554.18 EXF73077.1 - 2.7e-51 173.4 19.6 6.4e-27 94.2 8.3 2.3 2 0 0 2 2 2 2 MatE Polysacc_synt_C PF14667.6 EXF73077.1 - 1.4e-05 25.2 11.8 1.4e-05 25.2 11.8 4.3 3 2 0 3 3 3 1 Polysaccharide biosynthesis C-terminal domain GFO_IDH_MocA PF01408.22 EXF73078.1 - 5.3e-19 69.2 0.0 8.9e-19 68.5 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 EXF73078.1 - 0.015 15.3 0.0 0.026 14.5 0.0 1.4 1 0 0 1 1 1 0 Oxidoreductase family, C-terminal alpha/beta domain PseudoU_synth_2 PF00849.22 EXF73079.1 - 5.5e-32 111.1 0.0 7.9e-32 110.6 0.0 1.2 1 0 0 1 1 1 1 RNA pseudouridylate synthase Ub-Mut7C PF14451.6 EXF73079.1 - 0.0019 18.0 0.1 0.0044 16.8 0.1 1.6 1 0 0 1 1 1 1 Mut7-C ubiquitin DnaB_bind PF10410.9 EXF73079.1 - 0.14 12.4 0.0 0.33 11.2 0.0 1.6 1 0 0 1 1 1 0 DnaB-helicase binding domain of primase HAP1_N PF04849.13 EXF73080.1 - 0.0046 16.2 2.2 0.0052 16.0 2.2 1.1 1 0 0 1 1 1 1 HAP1 N-terminal conserved region CW_7 PF08230.11 EXF73080.1 - 0.013 15.2 0.9 1.2 8.9 0.2 3.1 2 1 0 2 2 2 0 CW_7 repeat Spc7 PF08317.11 EXF73080.1 - 0.016 14.1 2.6 0.018 14.0 2.6 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein BLOC1_2 PF10046.9 EXF73080.1 - 0.017 15.4 2.4 0.028 14.7 2.4 1.4 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Phage_GPO PF05929.11 EXF73080.1 - 0.042 13.5 2.0 0.044 13.4 2.0 1.1 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase DHquinase_I PF01487.15 EXF73080.1 - 0.052 13.8 0.0 0.062 13.5 0.0 1.2 1 0 0 1 1 1 0 Type I 3-dehydroquinase DUF1664 PF07889.12 EXF73080.1 - 0.083 12.9 0.6 0.15 12.1 0.3 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) Fib_alpha PF08702.10 EXF73080.1 - 0.12 12.5 3.5 0.12 12.5 1.0 1.9 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF1192 PF06698.11 EXF73080.1 - 3.9 7.6 6.9 0.87 9.7 1.1 2.7 3 1 0 3 3 3 0 Protein of unknown function (DUF1192) Fungal_trans PF04082.18 EXF73081.1 - 4.4e-10 39.0 0.7 1.8e-09 37.0 0.7 1.9 1 1 0 1 1 1 1 Fungal specific transcription factor domain GCV_T_C PF08669.11 EXF73081.1 - 1.5e-05 24.8 0.0 3.6e-05 23.6 0.0 1.6 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain zf-C2H2 PF00096.26 EXF73081.1 - 0.023 15.1 2.7 0.023 15.1 2.7 2.1 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 EXF73081.1 - 0.042 14.2 0.2 0.15 12.4 0.2 2.1 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 EXF73081.1 - 4 8.5 5.1 2.3 9.3 1.9 2.4 2 0 0 2 2 2 0 C2H2-type zinc finger p450 PF00067.22 EXF73082.1 - 5.8e-38 130.8 0.0 7.8e-38 130.4 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 COesterase PF00135.28 EXF73083.1 - 1.5e-73 248.4 0.0 1.9e-73 248.1 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EXF73083.1 - 0.012 15.4 6.5 0.29 10.9 6.3 2.8 1 1 0 1 1 1 0 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EXF73083.1 - 0.088 12.3 1.7 0.24 10.9 1.4 1.9 1 1 1 2 2 2 0 Prolyl oligopeptidase family Abhydrolase_3 PF07859.13 EXF73084.1 - 4.8e-27 95.2 0.0 6.5e-27 94.8 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 EXF73084.1 - 1.6e-12 47.0 0.0 9.6e-12 44.4 0.0 1.9 1 1 0 1 1 1 1 Steryl acetyl hydrolase DUF3089 PF11288.8 EXF73084.1 - 0.0017 17.9 0.0 0.0033 17.0 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3089) COesterase PF00135.28 EXF73084.1 - 0.0037 16.2 0.0 0.006 15.5 0.0 1.2 1 0 0 1 1 1 1 Carboxylesterase family COesterase PF00135.28 EXF73086.1 - 1.5e-64 218.7 0.0 2e-64 218.3 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EXF73086.1 - 1.5e-07 31.5 0.5 4.1e-05 23.5 0.1 2.4 2 0 0 2 2 2 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EXF73086.1 - 0.0037 16.8 0.1 0.0068 15.9 0.1 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family DUF4322 PF14210.6 EXF73086.1 - 0.13 12.1 0.1 0.25 11.2 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4322) FAD_binding_4 PF01565.23 EXF73087.1 - 3.3e-19 69.0 2.5 6.5e-19 68.0 1.7 1.9 1 1 1 2 2 2 1 FAD binding domain BBE PF08031.12 EXF73087.1 - 4.8e-10 39.4 0.3 1.1e-09 38.2 0.3 1.6 1 0 0 1 1 1 1 Berberine and berberine like PhyH PF05721.13 EXF73088.1 - 1.8e-17 64.3 0.0 2.8e-17 63.7 0.0 1.3 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) SCP2 PF02036.17 EXF73088.1 - 5.8e-05 23.5 0.0 0.00011 22.6 0.0 1.5 1 0 0 1 1 1 1 SCP-2 sterol transfer family Epimerase PF01370.21 EXF73089.1 - 1.1e-16 61.1 0.0 1.5e-16 60.6 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EXF73089.1 - 4.3e-11 42.3 0.0 5.1e-11 42.1 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 EXF73089.1 - 4.3e-10 39.2 0.1 8.1e-09 35.0 0.1 2.0 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.6 EXF73089.1 - 1.6e-06 28.2 1.1 6.4e-06 26.2 0.4 2.0 2 0 0 2 2 2 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 EXF73089.1 - 8.4e-06 25.4 0.0 1.2e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NmrA PF05368.13 EXF73089.1 - 0.00014 21.5 0.4 0.00055 19.6 0.5 1.9 2 1 0 2 2 2 1 NmrA-like family Polysacc_synt_2 PF02719.15 EXF73089.1 - 0.0003 20.0 0.1 0.0012 18.0 0.1 1.8 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein KR PF08659.10 EXF73089.1 - 0.0015 18.5 1.1 0.017 15.0 1.1 2.2 1 1 0 1 1 1 1 KR domain adh_short PF00106.25 EXF73089.1 - 0.0081 15.6 1.0 0.009 15.5 0.2 1.6 2 0 0 2 2 2 1 short chain dehydrogenase Mem_trans PF03547.18 EXF73090.1 - 5.9e-23 80.9 0.9 8.9e-23 80.3 0.9 1.3 1 0 0 1 1 1 1 Membrane transport protein SpoIIM PF01944.17 EXF73090.1 - 6.2 6.8 16.7 0.04 13.9 2.1 3.0 2 2 1 3 3 3 0 Stage II sporulation protein M ECH_1 PF00378.20 EXF73091.1 - 2.3e-39 135.2 0.0 7.8e-31 107.3 0.0 3.1 3 0 0 3 3 3 3 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EXF73091.1 - 6.7e-27 94.9 0.0 3.4e-22 79.4 0.0 2.2 2 0 0 2 2 2 2 Enoyl-CoA hydratase/isomerase Glyco_trans_4_4 PF13579.6 EXF73091.1 - 0.015 15.8 0.2 0.066 13.6 0.1 2.0 2 0 0 2 2 2 0 Glycosyl transferase 4-like domain Apolipoprotein PF01442.18 EXF73092.1 - 0.0005 20.0 1.4 0.00066 19.6 1.4 1.2 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain Borrelia_P83 PF05262.11 EXF73092.1 - 0.018 13.5 4.9 0.019 13.5 4.9 1.0 1 0 0 1 1 1 0 Borrelia P83/100 protein ApoLp-III PF07464.11 EXF73092.1 - 0.042 13.9 5.1 0.062 13.4 5.1 1.3 1 0 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) CsbD PF05532.12 EXF73092.1 - 0.055 13.4 19.9 1.1 9.2 5.9 3.5 1 1 1 2 2 2 0 CsbD-like DUF883 PF05957.13 EXF73092.1 - 0.16 12.6 4.1 0.62 10.7 4.1 1.9 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF883) YtxH PF12732.7 EXF73092.1 - 0.24 12.0 10.2 5 7.7 10.2 2.2 1 1 0 1 1 1 0 YtxH-like protein DivIVA PF05103.13 EXF73092.1 - 0.58 10.2 5.0 0.57 10.3 3.2 1.7 1 1 1 2 2 2 0 DivIVA protein ATP-synt_B PF00430.18 EXF73092.1 - 0.63 10.1 5.8 0.93 9.6 5.8 1.3 1 1 0 1 1 1 0 ATP synthase B/B' CF(0) DUF809 PF05663.11 EXF73092.1 - 0.95 9.6 3.8 1.1 9.4 3.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF809) LEA_4 PF02987.16 EXF73092.1 - 3.5 7.8 16.2 0.12 12.5 9.1 2.2 3 1 0 3 3 3 0 Late embryogenesis abundant protein DUF4470 PF14737.6 EXF73094.1 - 1.1e-19 70.4 0.1 2.6e-19 69.2 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4470) zf-MYND PF01753.18 EXF73094.1 - 1.3e-11 44.4 12.6 2.4e-11 43.5 12.6 1.5 1 0 0 1 1 1 1 MYND finger zf-C6H2 PF15801.5 EXF73094.1 - 1 9.7 9.5 2.4 8.5 9.5 1.6 1 0 0 1 1 1 0 zf-MYND-like zinc finger, mRNA-binding HET PF06985.11 EXF73095.1 - 8.3e-12 45.7 2.5 2.8e-08 34.2 0.2 2.4 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) ERp29_N PF07912.13 EXF73095.1 - 0.04 14.1 0.0 0.073 13.2 0.0 1.4 1 0 0 1 1 1 0 ERp29, N-terminal domain SpoVS PF04232.12 EXF73095.1 - 0.13 12.0 0.0 2.4 7.9 0.0 2.2 2 0 0 2 2 2 0 Stage V sporulation protein S (SpoVS) WSC PF01822.19 EXF73096.1 - 4.3e-11 42.9 9.3 1.1e-10 41.5 9.3 1.8 1 0 0 1 1 1 1 WSC domain SKG6 PF08693.10 EXF73096.1 - 3.9e-10 38.9 4.8 3.9e-10 38.9 4.8 2.2 2 0 0 2 2 2 1 Transmembrane alpha-helix domain DUF4366 PF14283.6 EXF73096.1 - 0.0012 18.9 1.6 0.0012 18.9 1.6 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4366) Alpha_GJ PF03229.13 EXF73096.1 - 0.0045 17.5 6.4 0.0045 17.5 6.4 2.0 2 0 0 2 2 2 1 Alphavirus glycoprotein J MGC-24 PF05283.11 EXF73096.1 - 0.0051 17.3 3.4 0.0051 17.3 3.4 2.3 2 1 0 2 2 1 1 Multi-glycosylated core protein 24 (MGC-24), sialomucin DUF5305 PF17231.2 EXF73096.1 - 0.017 14.5 0.8 0.031 13.7 0.8 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5305) FTCD PF02971.14 EXF73096.1 - 0.017 15.1 0.1 0.028 14.5 0.1 1.3 1 0 0 1 1 1 0 Formiminotransferase domain Insulin_TMD PF17870.1 EXF73096.1 - 0.018 15.1 0.0 0.033 14.3 0.0 1.4 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment PTP_tm PF18861.1 EXF73096.1 - 0.042 13.8 0.2 0.081 12.9 0.2 1.5 1 0 0 1 1 1 0 Transmembrane domain of protein tyrosine phosphatase, receptor type J Peptidase_M56 PF05569.11 EXF73096.1 - 0.05 12.8 0.1 0.074 12.2 0.1 1.2 1 0 0 1 1 1 0 BlaR1 peptidase M56 Nitrate_red_gam PF02665.14 EXF73096.1 - 0.13 11.8 0.4 0.25 10.8 0.4 1.6 1 0 0 1 1 1 0 Nitrate reductase gamma subunit DUF1230 PF06799.11 EXF73096.1 - 0.15 12.2 0.1 0.27 11.4 0.1 1.3 1 0 0 1 1 1 0 Conserved in the green lineage and diatoms 27 TetR_C_16 PF17920.1 EXF73096.1 - 0.15 12.3 0.7 0.27 11.5 0.7 1.3 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain MFS_MOT1 PF16983.5 EXF73096.1 - 0.93 9.9 8.0 0.47 10.9 5.0 1.9 2 0 0 2 2 2 0 Molybdate transporter of MFS superfamily CwsA PF10814.8 EXF73096.1 - 1 9.5 8.0 0.27 11.4 4.6 1.7 2 0 0 2 2 2 0 Cell wall synthesis protein CwsA Podoplanin PF05808.11 EXF73096.1 - 1.2 9.3 12.9 0.17 12.0 7.0 2.0 2 0 0 2 2 2 0 Podoplanin Gram_pos_anchor PF00746.21 EXF73096.1 - 4.3 7.4 9.2 0.16 12.0 2.4 2.3 2 1 0 2 2 1 0 LPXTG cell wall anchor motif TMEM154 PF15102.6 EXF73096.1 - 8.2 6.3 9.8 0.32 10.9 1.5 2.2 2 1 0 2 2 2 0 TMEM154 protein family Ice_nucleation PF00818.17 EXF73097.1 - 0.17 12.0 0.2 0.41 10.8 0.2 1.7 1 0 0 1 1 1 0 Ice nucleation protein repeat Conotoxin PF02950.17 EXF73100.1 - 0.036 15.1 0.8 0.05 14.6 0.8 1.4 1 0 0 1 1 1 0 Conotoxin zf-H2C2 PF09337.10 EXF73101.1 - 2.2e-16 59.8 1.0 4.3e-16 58.9 1.0 1.5 1 0 0 1 1 1 1 H2C2 zinc finger Integrase_H2C2 PF17921.1 EXF73101.1 - 1e-12 47.9 0.1 2.2e-12 46.9 0.1 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain Acetyltransf_4 PF13420.7 EXF73101.1 - 0.00039 20.6 0.0 0.00062 19.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EXF73101.1 - 0.00069 19.8 0.0 0.0013 18.9 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_3 PF13302.7 EXF73101.1 - 0.041 14.5 0.0 0.099 13.3 0.0 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain DUF2647 PF10839.8 EXF73101.1 - 0.14 12.2 0.0 0.33 11.0 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2647) Ribosomal_S2 PF00318.20 EXF73102.1 - 1.3e-63 214.1 0.1 8e-63 211.5 0.1 2.3 1 1 0 1 1 1 1 Ribosomal protein S2 CBS PF00571.28 EXF73102.1 - 2e-33 114.6 3.2 8.4e-09 35.8 0.0 5.0 4 0 0 4 4 4 4 CBS domain PB1 PF00564.24 EXF73102.1 - 1.3e-08 34.6 0.4 3.2e-08 33.4 0.0 2.0 2 0 0 2 2 2 1 PB1 domain PBP1_TM PF14812.6 EXF73102.1 - 0.095 13.1 0.1 0.095 13.1 0.1 1.8 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal zf-C2H2 PF00096.26 EXF73103.1 - 7.1e-08 32.5 26.0 0.00059 20.2 5.3 4.2 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EXF73103.1 - 1.5e-06 28.3 18.2 0.0014 18.9 1.9 4.4 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 EXF73103.1 - 0.00043 20.9 22.6 0.036 14.9 4.6 4.3 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2_11 PF16622.5 EXF73103.1 - 0.0026 17.5 7.3 0.033 13.9 1.7 2.7 2 0 0 2 2 2 2 zinc-finger C2H2-type AT_hook PF02178.19 EXF73103.1 - 1.5 9.0 4.0 4.1 7.6 4.0 1.8 1 0 0 1 1 1 0 AT hook motif C1_4 PF07975.12 EXF73103.1 - 6.8 7.0 7.9 16 5.8 7.9 1.7 1 0 0 1 1 1 0 TFIIH C1-like domain Cpn60_TCP1 PF00118.24 EXF73104.1 - 2e-152 508.3 7.1 2.3e-152 508.1 7.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family GNAT_acetyltran PF12746.7 EXF73104.1 - 0.035 13.7 0.1 0.092 12.3 0.1 1.7 1 0 0 1 1 1 0 GNAT acetyltransferase PNTB_4TM PF12769.7 EXF73104.1 - 0.057 13.9 0.0 0.23 12.0 0.0 2.0 2 0 0 2 2 2 0 4TM region of pyridine nucleotide transhydrogenase, mitoch HET PF06985.11 EXF73105.1 - 6.3e-32 110.9 0.3 1.3e-31 110.0 0.3 1.6 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) adh_short_C2 PF13561.6 EXF73106.1 - 1.3e-56 191.8 2.0 1.4e-56 191.6 2.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF73106.1 - 1.5e-41 142.0 2.0 2.1e-41 141.5 2.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EXF73106.1 - 0.00021 21.3 3.0 0.00057 19.8 3.0 1.7 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 EXF73106.1 - 0.00076 19.0 0.7 0.16 11.4 0.2 2.1 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family 3HCDH_N PF02737.18 EXF73106.1 - 0.029 14.2 1.4 0.044 13.7 1.4 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GDP_Man_Dehyd PF16363.5 EXF73106.1 - 0.047 13.1 0.2 5.9 6.2 0.0 2.1 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase THF_DHG_CYH_C PF02882.19 EXF73106.1 - 0.08 12.3 0.2 0.13 11.5 0.2 1.4 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain HEM4 PF02602.15 EXF73106.1 - 0.15 11.4 1.2 12 5.1 0.0 2.1 2 0 0 2 2 2 0 Uroporphyrinogen-III synthase HemD p450 PF00067.22 EXF73107.1 - 3.3e-29 101.9 0.0 1.9e-25 89.5 0.0 2.1 2 0 0 2 2 2 2 Cytochrome P450 iPGM_N PF06415.13 EXF73108.1 - 2.4e-77 259.2 0.0 3.5e-77 258.7 0.0 1.2 1 0 0 1 1 1 1 BPG-independent PGAM N-terminus (iPGM_N) Metalloenzyme PF01676.18 EXF73108.1 - 1.4e-65 221.1 0.1 1.6e-65 221.0 0.1 1.0 1 0 0 1 1 1 1 Metalloenzyme superfamily Sulfatase PF00884.23 EXF73108.1 - 1.5e-06 27.9 0.0 1.8e-05 24.3 0.0 2.1 1 1 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 EXF73108.1 - 6.1e-05 22.8 0.0 9.7e-05 22.1 0.0 1.3 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase AP_endonuc_2 PF01261.24 EXF73108.1 - 0.054 12.9 0.0 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 Xylose isomerase-like TIM barrel Med9 PF07544.13 EXF73109.1 - 7.8e-21 74.0 0.9 1.3e-20 73.3 0.9 1.3 1 0 0 1 1 1 1 RNA polymerase II transcription mediator complex subunit 9 Spc29 PF17082.5 EXF73109.1 - 4.5e-05 23.4 0.2 6.1e-05 23.0 0.2 1.1 1 0 0 1 1 1 1 Spindle Pole Component 29 Fib_alpha PF08702.10 EXF73109.1 - 0.0013 18.9 0.5 0.0024 18.1 0.4 1.4 2 0 0 2 2 2 1 Fibrinogen alpha/beta chain family Phage_GP20 PF06810.11 EXF73109.1 - 0.0015 18.4 0.5 0.0023 17.8 0.5 1.2 1 0 0 1 1 1 1 Phage minor structural protein GP20 Med21 PF11221.8 EXF73109.1 - 0.0017 18.6 0.0 0.0022 18.3 0.0 1.3 1 0 0 1 1 1 1 Subunit 21 of Mediator complex DUF16 PF01519.16 EXF73109.1 - 0.0085 16.6 0.4 0.013 16.0 0.4 1.3 1 0 0 1 1 1 1 Protein of unknown function DUF16 NPV_P10 PF05531.12 EXF73109.1 - 0.013 15.9 0.4 0.06 13.8 0.2 1.9 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein UPF0242 PF06785.11 EXF73109.1 - 0.022 14.9 2.0 0.03 14.4 2.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus FlxA PF14282.6 EXF73109.1 - 0.03 14.3 0.4 0.051 13.6 0.4 1.3 1 0 0 1 1 1 0 FlxA-like protein XhlA PF10779.9 EXF73109.1 - 0.11 12.7 1.3 0.22 11.7 1.3 1.6 1 0 0 1 1 1 0 Haemolysin XhlA SlyX PF04102.12 EXF73109.1 - 0.21 12.2 6.8 0.43 11.2 3.8 2.6 2 1 1 3 3 3 0 SlyX TBCC PF07986.12 EXF73110.1 - 5e-29 100.5 0.2 7.4e-29 99.9 0.2 1.3 1 0 0 1 1 1 1 Tubulin binding cofactor C TBCC_N PF16752.5 EXF73110.1 - 3.3e-11 43.6 0.1 6.4e-11 42.7 0.1 1.3 1 0 0 1 1 1 1 Tubulin-specific chaperone C N-terminal domain RTX PF02382.15 EXF73110.1 - 0.013 15.2 0.3 0.019 14.7 0.3 1.2 1 0 0 1 1 1 0 N-terminal domain in RTX protein F_actin_bind PF08919.10 EXF73110.1 - 0.13 12.4 0.1 1.7 8.8 0.0 2.3 1 1 1 2 2 2 0 F-actin binding NPV_P10 PF05531.12 EXF73110.1 - 0.45 11.0 1.8 6.5 7.3 0.3 2.3 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein LRR_6 PF13516.6 EXF73114.1 - 5.9e-16 57.1 2.8 0.0023 17.8 0.1 7.0 7 0 0 7 7 7 5 Leucine Rich repeat LRR_1 PF00560.33 EXF73114.1 - 0.0016 18.7 0.2 5.5 7.9 0.0 4.9 5 0 0 5 5 5 1 Leucine Rich Repeat LRR_4 PF12799.7 EXF73114.1 - 0.02 15.3 0.5 1.1e+02 3.5 0.0 4.6 5 1 0 5 5 5 0 Leucine Rich repeats (2 copies) MOZ_SAS PF01853.18 EXF73115.1 - 1.7e-51 174.4 0.0 3.7e-51 173.3 0.0 1.5 1 1 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 EXF73115.1 - 1.1e-08 34.5 0.5 0.0026 17.3 0.3 2.4 2 0 0 2 2 2 2 MYST family zinc finger domain PBCV_basic_adap PF08789.10 EXF73115.1 - 0.31 11.2 3.4 0.24 11.6 1.5 1.8 2 0 0 2 2 2 0 PBCV-specific basic adaptor domain PBP1_TM PF14812.6 EXF73115.1 - 2.5 8.5 6.6 1.6 9.2 0.4 2.8 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal adh_short PF00106.25 EXF73117.1 - 7.8e-30 103.8 0.0 8.8e-30 103.6 0.0 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF73117.1 - 1e-14 54.6 0.0 1.3e-14 54.3 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF73117.1 - 0.001 19.0 0.0 0.0014 18.6 0.0 1.2 1 0 0 1 1 1 1 KR domain Helo_like_N PF17111.5 EXF73119.1 - 6.8e-73 244.5 10.0 1.2e-70 237.1 3.1 2.3 2 0 0 2 2 2 2 Fungal N-terminal domain of STAND proteins Csm1_N PF18504.1 EXF73119.1 - 0.22 11.9 5.1 2.8 8.4 0.6 3.3 3 1 0 3 3 3 0 Csm1 N-terminal domain Allexi_40kDa PF05549.11 EXF73119.1 - 2.3 7.7 5.4 0.93 9.0 0.4 2.5 2 1 1 3 3 3 0 Allexivirus 40kDa protein DUF1664 PF07889.12 EXF73119.1 - 6.3 6.9 6.9 2.9 7.9 0.7 2.9 2 1 0 3 3 3 0 Protein of unknown function (DUF1664) KGG PF10685.9 EXF73120.1 - 7.4e-43 143.6 23.3 5.3e-10 39.2 0.2 5.2 5 0 0 5 5 5 5 Stress-induced bacterial acidophilic repeat motif HA70_C PF17993.1 EXF73120.1 - 0.28 11.2 0.3 49 4.0 0.0 2.9 1 1 2 3 3 3 0 Haemagglutinin 70 C-terminal domain Peptidase_C48 PF02902.19 EXF73121.1 - 1.5e-16 60.9 0.0 3.7e-16 59.6 0.0 1.6 1 1 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain Atg14 PF10186.9 EXF73122.1 - 0.35 9.9 8.5 0.75 8.8 8.5 1.5 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 YabA PF06156.13 EXF73122.1 - 1.3 9.7 8.3 12 6.6 2.6 2.5 1 1 1 2 2 2 0 Initiation control protein YabA TMPIT PF07851.13 EXF73122.1 - 2.8 7.1 5.9 4.3 6.5 5.9 1.2 1 0 0 1 1 1 0 TMPIT-like protein ERM PF00769.19 EXF73122.1 - 3.4 7.4 16.5 0.22 11.3 9.1 2.1 2 0 0 2 2 2 0 Ezrin/radixin/moesin family DUF4407 PF14362.6 EXF73122.1 - 5.2 6.3 9.1 12 5.2 8.3 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) PIP5K PF01504.18 EXF73123.1 - 6.3e-46 156.8 0.0 1.7e-44 152.1 0.0 2.0 1 1 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase HET PF06985.11 EXF73124.1 - 1.7e-23 83.6 0.1 2.9e-23 82.8 0.1 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) ACOX PF01756.19 EXF73125.1 - 9.2e-48 162.2 0.6 1.6e-47 161.4 0.6 1.4 1 0 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_ox_N PF14749.6 EXF73125.1 - 3.8e-29 101.8 0.6 8.6e-29 100.6 0.2 1.8 2 0 0 2 2 2 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_M PF02770.19 EXF73125.1 - 4.4e-13 49.2 0.0 1.9e-12 47.2 0.0 2.0 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.24 EXF73125.1 - 8.6e-06 26.0 0.9 0.0041 17.3 0.0 3.2 3 0 0 3 3 3 1 Acyl-CoA dehydrogenase, C-terminal domain Pec_lyase_C PF00544.19 EXF73127.1 - 2.7e-39 134.9 5.9 2.7e-39 134.9 5.9 1.7 2 0 0 2 2 2 1 Pectate lyase Beta_helix PF13229.6 EXF73127.1 - 0.0007 19.5 16.7 0.21 11.4 15.6 2.4 1 1 0 1 1 1 1 Right handed beta helix region MF_alpha_N PF05436.11 EXF73127.1 - 0.062 13.2 0.3 0.11 12.4 0.3 1.4 1 0 0 1 1 1 0 Mating factor alpha precursor N-terminus Gly_transf_sug PF04488.15 EXF73128.1 - 5.9e-12 46.1 1.3 9.1e-12 45.5 0.2 1.9 2 0 0 2 2 2 1 Glycosyltransferase sugar-binding region containing DXD motif DUF5527 PF17665.1 EXF73128.1 - 0.036 13.6 0.1 0.076 12.6 0.1 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5527) Caps_synth PF05704.12 EXF73128.1 - 0.3 10.4 0.0 0.3 10.4 0.0 2.0 2 0 0 2 2 2 0 Capsular polysaccharide synthesis protein Acyl_transf_3 PF01757.22 EXF73129.1 - 2.3e-36 125.5 30.3 3.2e-36 125.1 30.3 1.2 1 0 0 1 1 1 1 Acyltransferase family p450 PF00067.22 EXF73132.1 - 1.1e-30 106.9 0.0 1.3e-30 106.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Herpes_BTRF1 PF04682.12 EXF73133.1 - 0.11 11.9 0.0 0.12 11.6 0.0 1.2 1 0 0 1 1 1 0 Herpesvirus BTRF1 protein conserved region Torsin PF06309.11 EXF73134.1 - 0.076 13.1 0.0 0.085 13.0 0.0 1.3 1 0 0 1 1 1 0 Torsin Cation_ATPase_C PF00689.21 EXF73135.1 - 2.8e-45 154.3 6.5 2.8e-45 154.3 6.5 2.5 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 EXF73135.1 - 1e-34 119.6 1.2 1e-34 119.6 1.2 2.9 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase PF13246.6 EXF73135.1 - 1.9e-21 76.0 0.0 3.7e-21 75.0 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EXF73135.1 - 2.3e-21 77.1 4.2 7.1e-21 75.5 4.2 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EXF73135.1 - 2.2e-12 46.4 0.1 3.2e-10 39.6 0.0 3.0 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EXF73135.1 - 0.00031 20.6 0.3 0.00097 18.9 0.1 1.9 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Sugar_tr PF00083.24 EXF73136.1 - 1.8e-117 393.0 17.4 2e-117 392.8 17.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF73136.1 - 9.1e-28 97.2 47.2 2.7e-26 92.3 18.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Abhydrolase_1 PF00561.20 EXF73138.1 - 8.6e-23 81.3 0.2 6.3e-22 78.5 0.2 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EXF73138.1 - 1.1e-16 62.2 2.7 1.8e-16 61.4 2.7 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EXF73138.1 - 7.6e-10 38.5 0.1 1.2e-09 37.8 0.1 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Ndr PF03096.14 EXF73138.1 - 0.007 15.1 0.0 0.0092 14.7 0.0 1.1 1 0 0 1 1 1 1 Ndr family EHN PF06441.12 EXF73138.1 - 0.025 14.9 0.0 0.052 13.9 0.0 1.5 1 0 0 1 1 1 0 Epoxide hydrolase N terminus DUF1057 PF06342.12 EXF73138.1 - 0.21 10.6 0.0 0.28 10.2 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1057) HET PF06985.11 EXF73142.1 - 1.6e-08 35.0 0.4 7.6e-06 26.3 0.0 2.8 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) Exo_endo_phos PF03372.23 EXF73143.1 - 3.7e-05 23.3 0.4 0.00012 21.7 0.4 1.8 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family M-inducer_phosp PF06617.13 EXF73143.1 - 0.037 13.3 0.1 0.052 12.8 0.1 1.2 1 0 0 1 1 1 0 M-phase inducer phosphatase Ribonuc_L-PSP PF01042.21 EXF73144.1 - 3.3e-15 56.1 0.0 4.4e-15 55.8 0.0 1.1 1 0 0 1 1 1 1 Endoribonuclease L-PSP Sulfotransfer_4 PF17784.1 EXF73145.1 - 3.4e-52 177.4 0.0 3.9e-52 177.2 0.0 1.0 1 0 0 1 1 1 1 Sulfotransferase domain UDPGT PF00201.18 EXF73146.1 - 8e-19 67.8 0.0 1.4e-16 60.4 0.0 2.2 2 0 0 2 2 2 2 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_transf_28 PF03033.20 EXF73146.1 - 8.2e-05 22.7 0.0 0.00018 21.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain Glyco_tran_28_C PF04101.16 EXF73146.1 - 0.009 16.0 0.0 0.015 15.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Epimerase_2 PF02350.19 EXF73146.1 - 0.014 14.2 0.0 0.087 11.7 0.0 2.0 2 0 0 2 2 2 0 UDP-N-acetylglucosamine 2-epimerase Glyco_transf_4 PF13439.6 EXF73146.1 - 0.017 15.1 0.1 0.054 13.5 0.1 1.8 1 1 0 1 1 1 0 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 EXF73146.1 - 0.13 12.7 1.5 0.25 11.8 0.2 2.1 3 0 0 3 3 3 0 Glycosyl transferase 4-like domain adh_short_C2 PF13561.6 EXF73146.1 - 0.27 10.7 3.7 2.4 7.6 0.8 2.3 2 0 0 2 2 2 0 Enoyl-(Acyl carrier protein) reductase Trp_DMAT PF11991.8 EXF73147.1 - 6.1e-97 325.3 0.0 6.9e-97 325.1 0.0 1.0 1 0 0 1 1 1 1 Tryptophan dimethylallyltransferase DUF4351 PF14261.6 EXF73147.1 - 0.17 11.9 0.5 0.33 11.0 0.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4351) p450 PF00067.22 EXF73148.1 - 9.9e-67 225.7 0.0 1.2e-66 225.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF423 PF04241.15 EXF73150.1 - 2.6e-23 82.0 1.0 5.5e-23 81.0 1.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF423) Bax1-I PF01027.20 EXF73150.1 - 0.0042 16.9 0.6 0.005 16.7 0.6 1.1 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 ADH_N PF08240.12 EXF73151.1 - 4.3e-18 65.2 0.2 1.2e-17 63.7 0.2 1.8 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EXF73151.1 - 8.1e-09 35.5 0.9 2.1e-06 27.7 0.2 2.9 2 1 0 2 2 2 2 Zinc-binding dehydrogenase HI0933_like PF03486.14 EXF73151.1 - 0.0003 19.6 0.2 0.00041 19.2 0.2 1.1 1 0 0 1 1 1 1 HI0933-like protein AlaDh_PNT_C PF01262.21 EXF73151.1 - 0.091 12.0 0.0 0.13 11.5 0.0 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox_2 PF07992.14 EXF73151.1 - 0.1 11.8 0.0 0.19 10.9 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Glu_dehyd_C PF16912.5 EXF73151.1 - 0.16 11.4 0.4 1.5 8.3 0.0 2.5 3 0 0 3 3 3 0 Glucose dehydrogenase C-terminus GFA PF04828.14 EXF73153.1 - 6.6e-26 90.5 1.2 1e-25 89.9 1.2 1.3 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme ABC_tran PF00005.27 EXF73154.1 - 8.6e-33 113.8 0.0 1.8e-32 112.7 0.0 1.6 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 EXF73154.1 - 2.9e-24 86.2 3.0 2.9e-24 86.2 3.0 2.2 3 0 0 3 3 3 1 ABC transporter transmembrane region SMC_N PF02463.19 EXF73154.1 - 4.4e-05 23.0 0.0 0.00016 21.2 0.0 1.7 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain PAM2 PF07145.15 EXF73154.1 - 0.00074 19.0 0.2 0.024 14.3 0.1 2.5 2 0 0 2 2 2 1 Ataxin-2 C-terminal region RsgA_GTPase PF03193.16 EXF73154.1 - 0.0052 16.7 0.1 0.01 15.7 0.1 1.4 1 0 0 1 1 1 1 RsgA GTPase T2SSE PF00437.20 EXF73154.1 - 0.0078 15.3 0.0 0.16 11.0 0.0 2.2 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_30 PF13604.6 EXF73154.1 - 0.034 13.9 0.0 0.09 12.5 0.0 1.6 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 EXF73154.1 - 0.084 12.1 0.0 0.16 11.2 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_29 PF13555.6 EXF73154.1 - 0.1 12.4 0.3 0.31 10.8 0.3 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_15 PF13175.6 EXF73154.1 - 0.11 12.2 0.0 0.19 11.4 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain MTABC_N PF16185.5 EXF73154.1 - 5.3 6.5 11.5 4.1 6.8 0.1 3.4 3 0 0 3 3 3 0 Mitochondrial ABC-transporter N-terminal five TM region SGTA_dimer PF16546.5 EXF73155.1 - 9.4e-25 86.2 0.5 2e-24 85.1 0.5 1.6 1 0 0 1 1 1 1 Homodimerisation domain of SGTA TPR_1 PF00515.28 EXF73155.1 - 1.2e-15 56.6 4.7 7.9e-07 28.6 0.3 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 EXF73155.1 - 1.2e-13 50.0 7.4 7.2e-06 25.7 0.2 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 EXF73155.1 - 4.9e-09 35.7 3.2 3.9e-05 23.2 0.6 3.2 2 1 1 3 3 3 3 TPR repeat TPR_8 PF13181.6 EXF73155.1 - 1.6e-08 34.1 3.4 0.17 12.2 0.0 4.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.6 EXF73155.1 - 5.4e-07 30.2 22.0 0.0026 18.3 8.2 2.7 1 1 0 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.6 EXF73155.1 - 4.6e-06 26.7 2.6 0.0011 19.2 0.4 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat STI1 PF17830.1 EXF73155.1 - 0.00018 21.4 11.3 0.0011 18.8 8.2 2.4 2 0 0 2 2 2 1 STI1 domain TPR_14 PF13428.6 EXF73155.1 - 0.00021 21.8 14.0 0.076 13.9 0.2 4.3 2 1 3 5 5 5 3 Tetratricopeptide repeat TPR_19 PF14559.6 EXF73155.1 - 0.00025 21.5 0.8 0.00025 21.5 0.8 3.4 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 EXF73155.1 - 0.00075 19.4 0.2 0.33 11.1 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.6 EXF73155.1 - 0.0013 18.8 1.4 0.036 14.2 0.7 2.5 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 EXF73155.1 - 0.0027 18.0 6.7 0.0075 16.5 2.6 2.9 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.6 EXF73155.1 - 0.045 13.6 4.1 0.77 9.7 0.3 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat BTAD PF03704.17 EXF73155.1 - 0.056 13.9 7.6 14 6.1 7.6 2.7 1 1 0 1 1 1 0 Bacterial transcriptional activator domain XPC-binding PF09280.11 EXF73155.1 - 0.21 11.4 4.4 0.15 11.8 2.2 1.8 2 0 0 2 2 2 0 XPC-binding domain TPR_6 PF13174.6 EXF73155.1 - 1.9 9.3 5.5 3 8.7 0.3 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat Methyltransf_3 PF01596.17 EXF73156.1 - 9.4e-30 103.4 0.0 2e-29 102.3 0.0 1.4 1 1 0 1 1 1 1 O-methyltransferase PCMT PF01135.19 EXF73156.1 - 2.6e-10 40.4 0.0 3.4e-10 40.0 0.0 1.1 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_24 PF13578.6 EXF73156.1 - 9.7e-10 39.4 0.0 2.3e-09 38.2 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF73156.1 - 1.7e-09 37.6 0.0 2.6e-09 37.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF73156.1 - 3.8e-06 27.5 0.0 7.6e-06 26.6 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 EXF73156.1 - 0.014 14.8 0.0 0.025 14.0 0.0 1.4 1 0 0 1 1 1 0 Putative methyltransferase Methyltransf_12 PF08242.12 EXF73156.1 - 0.025 15.3 0.0 0.052 14.3 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain Fibrillarin PF01269.17 EXF73156.1 - 0.11 11.6 0.0 0.15 11.1 0.0 1.3 1 0 0 1 1 1 0 Fibrillarin Methyltransf_11 PF08241.12 EXF73156.1 - 0.15 12.7 0.1 1.1 9.9 0.1 2.1 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.6 EXF73160.1 - 1.1e-24 87.2 0.0 1.6e-24 86.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF73160.1 - 1.8e-11 44.6 0.0 4.3e-11 43.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF73160.1 - 1.1e-09 38.3 0.0 3.3e-08 33.5 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF73160.1 - 2.6e-08 34.4 0.0 4.4e-08 33.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF73160.1 - 1.2e-07 32.4 0.0 1.1e-06 29.3 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EXF73160.1 - 0.011 15.3 0.0 0.018 14.6 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain FtsJ PF01728.19 EXF73160.1 - 0.015 15.4 0.0 0.025 14.7 0.0 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase PCMT PF01135.19 EXF73160.1 - 0.034 13.9 0.0 0.058 13.1 0.0 1.5 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PrmA PF06325.13 EXF73160.1 - 0.052 12.9 0.0 0.079 12.3 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Maf1 PF09174.10 EXF73161.1 - 3.1e-56 190.3 0.0 4.8e-56 189.6 0.0 1.3 1 0 0 1 1 1 1 Maf1 regulator Clat_adaptor_s PF01217.20 EXF73161.1 - 2.1e-50 170.4 1.5 3.3e-50 169.7 1.5 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain PulA_N1 PF17999.1 EXF73161.1 - 0.095 13.5 0.0 0.23 12.2 0.0 1.6 1 0 0 1 1 1 0 Pullulanase N1-terminal domain Aldo_ket_red PF00248.21 EXF73162.1 - 1.2e-08 34.5 0.0 1.6e-08 34.1 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family ECR1_N PF14382.6 EXF73163.1 - 8.1e-18 63.9 1.4 1.6e-17 63.0 1.4 1.5 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region KH_6 PF15985.5 EXF73163.1 - 0.00046 20.5 0.1 0.0009 19.5 0.1 1.5 1 0 0 1 1 1 1 KH domain EXOSC1 PF10447.9 EXF73163.1 - 0.074 13.7 3.6 0.62 10.7 0.1 3.3 3 1 1 4 4 4 0 Exosome component EXOSC1/CSL4 DUF4536 PF15055.6 EXF73164.1 - 9.1e-06 25.8 4.9 2.3e-05 24.5 4.9 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF4536) Adap_comp_sub PF00928.21 EXF73165.1 - 1.6e-70 237.5 0.0 2e-70 237.2 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 EXF73165.1 - 3e-05 24.0 0.0 4.6e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Acyl_transf_1 PF00698.21 EXF73166.1 - 2.2e-18 66.9 0.0 5.3e-13 49.1 0.0 2.2 2 0 0 2 2 2 2 Acyl transferase domain DUF2458 PF10454.9 EXF73166.1 - 0.16 11.6 0.0 0.25 11.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2458) Sedlin_N PF04628.13 EXF73167.1 - 7.5e-14 52.0 0.0 1.2e-13 51.3 0.0 1.3 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Sybindin PF04099.12 EXF73167.1 - 0.2 11.6 0.0 7.5 6.5 0.0 2.2 2 0 0 2 2 2 0 Sybindin-like family AFG1_ATPase PF03969.16 EXF73168.1 - 2.6e-54 184.5 0.4 4e-27 95.1 0.0 4.7 5 0 0 5 5 5 3 AFG1-like ATPase AAA_16 PF13191.6 EXF73168.1 - 2.1e-05 25.0 1.4 0.0036 17.7 0.0 3.1 2 1 1 3 3 3 1 AAA ATPase domain AAA_5 PF07728.14 EXF73168.1 - 0.00023 21.1 0.0 0.00057 19.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EXF73168.1 - 0.0024 18.1 0.0 0.0079 16.5 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 EXF73168.1 - 0.013 15.9 0.0 0.027 14.9 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 EXF73168.1 - 0.05 13.6 0.0 0.1 12.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EXF73168.1 - 0.052 13.3 0.0 0.13 12.0 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain TsaE PF02367.17 EXF73168.1 - 0.094 12.7 0.0 0.2 11.6 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 EXF73168.1 - 0.15 12.0 0.0 0.35 10.8 0.0 1.7 1 0 0 1 1 1 0 NACHT domain ABC_tran PF00005.27 EXF73168.1 - 0.16 12.5 0.1 4.1 7.9 0.1 2.3 1 1 1 2 2 2 0 ABC transporter Nucleoporin_C PF03177.14 EXF73169.1 - 1.4e-193 644.9 18.8 1.8e-193 644.6 18.8 1.1 1 0 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal Nucleoporin_N PF08801.11 EXF73169.1 - 1.1e-84 284.8 0.0 1.4e-84 284.4 0.0 1.1 1 0 0 1 1 1 1 Nup133 N terminal like Pkinase PF00069.25 EXF73170.1 - 4.9e-27 95.0 0.0 6.3e-27 94.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF73170.1 - 2.6e-14 53.2 0.0 3.3e-14 52.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EXF73170.1 - 1.1e-06 27.7 0.0 1.5e-06 27.3 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Peptidase_M44 PF03410.13 EXF73170.1 - 0.17 10.4 0.0 0.24 9.9 0.0 1.1 1 0 0 1 1 1 0 Metallopeptidase from vaccinia pox Fungal_trans PF04082.18 EXF73171.1 - 1.1e-12 47.5 0.0 2.3e-12 46.5 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF73171.1 - 1.9e-05 24.7 7.0 3.6e-05 23.8 7.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Ribosomal_L20 PF00453.18 EXF73171.1 - 0.29 11.2 3.0 0.93 9.6 3.0 1.8 1 0 0 1 1 1 0 Ribosomal protein L20 MM_CoA_mutase PF01642.22 EXF73171.1 - 0.55 8.7 4.0 0.8 8.2 4.0 1.1 1 0 0 1 1 1 0 Methylmalonyl-CoA mutase Hexapep_2 PF14602.6 EXF73172.1 - 2.9e-14 52.5 23.3 3.4e-09 36.3 3.6 3.2 4 0 0 4 4 4 2 Hexapeptide repeat of succinyl-transferase Mac PF12464.8 EXF73172.1 - 2.5e-13 50.1 0.4 8e-13 48.4 0.0 2.0 2 0 0 2 2 2 1 Maltose acetyltransferase Hexapep PF00132.24 EXF73172.1 - 1.4e-12 46.8 20.3 1.6e-08 33.9 3.1 4.0 4 1 0 4 4 4 3 Bacterial transferase hexapeptide (six repeats) Zn_clus PF00172.18 EXF73172.1 - 1.2e-09 38.1 8.6 2.4e-09 37.2 8.6 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain APG5 PF04106.12 EXF73173.1 - 1.7e-42 145.6 0.0 6.5e-42 143.7 0.0 1.8 1 1 0 1 1 1 1 Autophagy protein Apg5 zf-HYPF PF07503.12 EXF73174.1 - 0.024 14.4 1.8 0.083 12.7 1.8 1.9 1 0 0 1 1 1 0 HypF finger FYDLN_acid PF09538.10 EXF73174.1 - 0.12 13.1 0.1 0.12 13.1 0.1 2.8 3 0 0 3 3 3 0 Protein of unknown function (FYDLN_acid) Methyltransf_23 PF13489.6 EXF73175.1 - 1.5e-11 44.4 0.0 2.7e-11 43.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF73175.1 - 1.7e-08 35.0 0.0 7.2e-08 33.0 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF73175.1 - 3.8e-07 30.7 0.0 1.4e-05 25.7 0.0 2.4 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF73175.1 - 0.0016 19.2 0.0 0.0042 17.8 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF73175.1 - 0.018 14.8 0.0 0.026 14.3 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Ntox10 PF15520.6 EXF73176.1 - 0.0006 19.8 0.0 0.001 19.0 0.0 1.3 1 0 0 1 1 1 1 Novel toxin 10 Ldh_2 PF02615.14 EXF73177.1 - 3.9e-124 414.2 1.0 4.4e-124 414.0 1.0 1.0 1 0 0 1 1 1 1 Malate/L-lactate dehydrogenase Fungal_trans PF04082.18 EXF73178.1 - 3e-15 56.0 0.5 2.9e-13 49.5 0.5 2.3 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF73178.1 - 6.8e-10 38.9 8.9 1.3e-09 38.0 8.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PRIMA1 PF16101.5 EXF73178.1 - 0.03 14.4 1.1 0.075 13.1 1.1 1.6 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 MHC_II_alpha PF00993.20 EXF73178.1 - 0.24 11.1 0.3 0.63 9.8 0.3 1.6 1 0 0 1 1 1 0 Class II histocompatibility antigen, alpha domain HypA PF01155.19 EXF73178.1 - 0.48 10.5 2.6 1.2 9.2 2.6 1.6 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA ILVD_EDD PF00920.21 EXF73179.1 - 1.3e-158 528.9 0.2 1.4e-158 528.7 0.2 1.0 1 0 0 1 1 1 1 Dehydratase family adh_short_C2 PF13561.6 EXF73180.1 - 1.3e-57 195.1 5.4 4.2e-57 193.4 5.4 1.6 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF73180.1 - 1.5e-40 138.7 3.4 2e-40 138.3 3.4 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EXF73180.1 - 0.0058 16.6 0.5 0.0092 15.9 0.5 1.3 1 0 0 1 1 1 1 KR domain 2-Hacid_dh_C PF02826.19 EXF73180.1 - 0.14 11.5 0.3 0.25 10.7 0.3 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain MFS_1 PF07690.16 EXF73181.1 - 1.7e-24 86.5 21.9 1.7e-24 86.5 21.9 1.6 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF4538 PF15061.6 EXF73181.1 - 0.26 11.0 1.9 4.3 7.1 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4538) DUF423 PF04241.15 EXF73181.1 - 8.5 6.7 8.7 27 5.1 1.9 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF423) Glyco_hydro_88 PF07470.13 EXF73182.1 - 7.6e-10 38.4 0.2 1.2e-09 37.7 0.2 1.4 1 0 0 1 1 1 1 Glycosyl Hydrolase Family 88 Fungal_trans PF04082.18 EXF73183.1 - 1.4e-22 80.0 0.1 2.8e-22 79.0 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF73183.1 - 0.0019 18.3 14.0 0.0034 17.5 14.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF885 PF05960.11 EXF73184.1 - 3e-35 122.9 0.6 1.6e-34 120.5 0.6 1.9 1 1 0 1 1 1 1 Bacterial protein of unknown function (DUF885) DUF4253 PF14062.6 EXF73184.1 - 0.0018 18.4 0.0 0.0048 17.0 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4253) DUF4286 PF14114.6 EXF73184.1 - 0.037 14.5 0.4 0.094 13.2 0.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4286) Arylsulfotran_2 PF14269.6 EXF73185.1 - 3.7e-97 325.3 0.1 5.6e-97 324.7 0.1 1.3 1 0 0 1 1 1 1 Arylsulfotransferase (ASST) Arylsulfotrans PF05935.11 EXF73185.1 - 2.1e-09 36.8 0.0 2e-08 33.6 0.0 2.0 1 1 0 1 1 1 1 Arylsulfotransferase (ASST) BTK PF00779.19 EXF73186.1 - 2.6 7.9 10.5 0.26 11.1 1.6 2.6 2 0 0 2 2 2 0 BTK motif RicinB_lectin_2 PF14200.6 EXF73188.1 - 0.021 15.5 0.0 0.39 11.5 0.0 2.1 1 1 1 2 2 2 0 Ricin-type beta-trefoil lectin domain-like Acetyltransf_10 PF13673.7 EXF73189.1 - 1.1e-12 48.0 0.0 1.4e-12 47.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EXF73189.1 - 1.2e-12 48.1 0.0 1.5e-12 47.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EXF73189.1 - 6.5e-12 45.7 0.0 9.7e-12 45.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EXF73189.1 - 0.0035 17.3 0.0 0.0057 16.6 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.6 EXF73189.1 - 0.0049 17.0 0.0 0.009 16.1 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase MOZ_SAS PF01853.18 EXF73189.1 - 0.096 12.3 0.0 0.12 12.0 0.0 1.2 1 0 0 1 1 1 0 MOZ/SAS family Tim17 PF02466.19 EXF73190.1 - 1.6e-19 70.3 8.1 3.8e-17 62.7 8.1 2.1 1 1 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Asparaginase_2 PF01112.18 EXF73191.1 - 4.8e-48 163.8 10.1 1.3e-27 96.6 2.1 3.8 3 1 0 3 3 3 3 Asparaginase FAR1 PF03101.15 EXF73192.1 - 0.0025 18.5 0.0 0.0057 17.3 0.0 1.5 1 0 0 1 1 1 1 FAR1 DNA-binding domain Phosphodiest PF01663.22 EXF73192.1 - 0.005 16.5 0.0 0.015 14.9 0.0 1.7 2 0 0 2 2 2 1 Type I phosphodiesterase / nucleotide pyrophosphatase FRB_dom PF08771.11 EXF73192.1 - 0.087 13.2 0.3 0.87 10.0 0.1 2.4 2 0 0 2 2 2 0 FKBP12-rapamycin binding domain Golgin_A5 PF09787.9 EXF73192.1 - 5.9 6.3 12.5 0.13 11.7 1.8 2.1 2 0 0 2 2 2 0 Golgin subfamily A member 5 AAA_6 PF12774.7 EXF73193.1 - 3e-126 420.8 0.0 1.7e-125 418.3 0.0 2.5 2 0 0 2 2 1 1 Hydrolytic ATP binding site of dynein motor region DHC_N1 PF08385.12 EXF73193.1 - 1.2e-117 394.0 7.4 1.2e-117 394.0 7.4 4.8 5 0 0 5 5 5 1 Dynein heavy chain, N-terminal region 1 DHC_N2 PF08393.13 EXF73193.1 - 3.8e-117 391.7 7.7 3.8e-117 391.7 7.7 6.1 5 2 0 5 5 5 1 Dynein heavy chain, N-terminal region 2 AAA_9 PF12781.7 EXF73193.1 - 6.2e-73 244.6 1.4 6.2e-73 244.6 1.4 3.1 3 0 0 3 3 2 1 ATP-binding dynein motor region AAA_8 PF12780.7 EXF73193.1 - 2.1e-65 220.7 0.0 6.8e-65 219.0 0.0 2.0 2 0 0 2 2 2 1 P-loop containing dynein motor region D4 AAA_7 PF12775.7 EXF73193.1 - 5.4e-43 146.6 0.0 2.7e-36 124.8 0.0 4.9 5 0 0 5 5 5 2 P-loop containing dynein motor region MT PF12777.7 EXF73193.1 - 1.1e-36 126.5 7.2 1.1e-36 126.5 7.2 1.9 2 0 0 2 2 2 1 Microtubule-binding stalk of dynein motor AAA_5 PF07728.14 EXF73193.1 - 4.9e-33 114.0 0.1 6.8e-12 45.6 0.0 6.3 5 1 0 5 5 5 4 AAA domain (dynein-related subfamily) Dynein_heavy PF03028.15 EXF73193.1 - 4.4e-29 101.0 0.0 4.7e-27 94.4 0.0 3.4 2 0 0 2 2 2 1 Dynein heavy chain region D6 P-loop domain AAA_lid_11 PF18198.1 EXF73193.1 - 1.8e-28 99.4 0.0 4.5e-28 98.1 0.0 1.7 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_22 PF13401.6 EXF73193.1 - 4.7e-15 56.1 0.9 0.0097 16.2 0.0 6.2 4 1 0 4 4 4 3 AAA domain Dynein_AAA_lid PF17852.1 EXF73193.1 - 9.2e-15 54.9 0.0 4.6e-14 52.6 0.0 2.3 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA PF00004.29 EXF73193.1 - 7.2e-14 52.3 0.1 0.002 18.5 0.0 5.3 5 0 0 5 5 5 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EXF73193.1 - 1.5e-10 41.7 4.1 1.8 8.9 0.0 7.9 7 0 0 7 7 6 2 AAA ATPase domain AAA_33 PF13671.6 EXF73193.1 - 6.6e-09 36.1 1.1 0.46 10.6 0.1 5.1 4 0 0 4 4 4 3 AAA domain AAA_18 PF13238.6 EXF73193.1 - 2.1e-08 34.8 0.5 0.1 13.2 0.0 5.3 4 0 0 4 4 4 2 AAA domain T2SSE PF00437.20 EXF73193.1 - 3.1e-05 23.2 0.0 0.02 14.0 0.0 3.1 3 0 0 3 3 3 1 Type II/IV secretion system protein AAA_29 PF13555.6 EXF73193.1 - 4.1e-05 23.2 0.1 2.3 8.0 0.0 3.7 3 0 0 3 3 3 2 P-loop containing region of AAA domain AAA_lid_1 PF17857.1 EXF73193.1 - 6.8e-05 23.0 0.4 0.0011 19.2 0.0 3.1 3 0 0 3 3 2 1 AAA+ lid domain Mg_chelatase PF01078.21 EXF73193.1 - 0.00032 20.1 1.0 0.68 9.3 0.0 3.7 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_30 PF13604.6 EXF73193.1 - 0.0013 18.5 0.6 39 3.9 0.0 4.9 4 0 0 4 4 4 0 AAA domain IstB_IS21 PF01695.17 EXF73193.1 - 0.0017 18.1 0.7 0.65 9.7 0.0 4.3 4 0 0 4 4 4 1 IstB-like ATP binding protein ABC_tran PF00005.27 EXF73193.1 - 0.0017 18.9 1.7 6.2 7.3 0.0 4.9 4 0 0 4 4 3 0 ABC transporter BRE1 PF08647.11 EXF73193.1 - 0.0038 17.3 2.6 0.0038 17.3 2.6 4.7 4 0 0 4 4 2 1 BRE1 E3 ubiquitin ligase AAA_19 PF13245.6 EXF73193.1 - 0.0041 17.5 4.0 0.28 11.5 0.0 4.5 5 0 0 5 5 4 1 AAA domain AAA_25 PF13481.6 EXF73193.1 - 0.0071 15.9 3.6 0.24 10.9 0.0 3.6 4 0 0 4 4 3 1 AAA domain RNA_helicase PF00910.22 EXF73193.1 - 0.0083 16.5 0.1 28 5.1 0.0 4.6 4 0 0 4 4 4 0 RNA helicase FtsK_SpoIIIE PF01580.18 EXF73193.1 - 0.02 14.3 3.1 2.4 7.4 0.0 4.3 4 0 0 4 4 4 0 FtsK/SpoIIIE family DUF4482 PF14818.6 EXF73193.1 - 0.042 14.7 7.5 39 5.1 8.2 3.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4482) Rad17 PF03215.15 EXF73193.1 - 0.049 13.6 0.1 6.8 6.6 0.0 3.6 4 0 0 4 4 2 0 Rad17 P-loop domain AAA_24 PF13479.6 EXF73193.1 - 0.071 12.8 5.8 11 5.7 0.0 4.7 5 0 0 5 5 5 0 AAA domain PduV-EutP PF10662.9 EXF73193.1 - 1.1 9.0 3.9 11 5.7 0.1 3.9 4 0 0 4 4 4 0 Ethanolamine utilisation - propanediol utilisation ALMT PF11744.8 EXF73193.1 - 1.5 7.6 5.9 5.7 5.7 5.9 2.0 1 0 0 1 1 1 0 Aluminium activated malate transporter MbeB_N PF04837.12 EXF73193.1 - 1.9 8.9 6.1 2.9 8.3 0.1 3.9 3 0 0 3 3 2 0 MbeB-like, N-term conserved region NACHT PF05729.12 EXF73193.1 - 9.5 6.1 7.0 32 4.4 0.0 4.2 4 0 0 4 4 3 0 NACHT domain DUF1774 PF08611.10 EXF73194.1 - 7.7e-37 125.5 1.3 7.7e-37 125.5 1.3 2.7 3 0 0 3 3 3 1 Fungal protein of unknown function (DUF1774) ACPS PF01648.20 EXF73194.1 - 1.7e-05 25.0 0.3 3.7e-05 23.8 0.3 1.6 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily 4PPT_N PF17837.1 EXF73194.1 - 0.00042 20.4 0.2 1.4 9.1 0.0 2.7 2 0 0 2 2 2 2 4'-phosphopantetheinyl transferase N-terminal domain Clr5 PF14420.6 EXF73195.1 - 1.4e-06 28.5 0.1 3.1e-06 27.3 0.1 1.6 1 0 0 1 1 1 1 Clr5 domain F-box PF00646.33 EXF73196.1 - 0.026 14.4 0.0 0.052 13.5 0.0 1.4 1 0 0 1 1 1 0 F-box domain PRELI PF04707.14 EXF73196.1 - 0.16 11.8 0.0 0.25 11.2 0.0 1.3 1 0 0 1 1 1 0 PRELI-like family Glutaredoxin PF00462.24 EXF73197.1 - 9.8e-14 51.3 0.0 3.3e-13 49.6 0.0 2.0 1 0 0 1 1 1 1 Glutaredoxin PPL5 PF18168.1 EXF73197.1 - 0.37 10.0 4.1 0.56 9.4 4.1 1.2 1 0 0 1 1 1 0 Prim-pol family 5 SAPS PF04499.15 EXF73197.1 - 3.1 6.5 9.1 9.4 4.9 6.4 2.0 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein DUF1804 PF08822.11 EXF73198.1 - 0.055 13.5 0.4 0.1 12.6 0.1 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1804) GFA PF04828.14 EXF73199.1 - 9.6e-11 41.9 0.0 2e-06 28.0 0.3 2.5 2 0 0 2 2 2 2 Glutathione-dependent formaldehyde-activating enzyme DUF2526 PF10735.9 EXF73199.1 - 0.42 10.8 1.7 1 9.5 1.7 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2526) Glyco_hydro_53 PF07745.13 EXF73200.1 - 4.6e-102 341.5 0.3 5.2e-102 341.3 0.3 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 53 Zn_clus PF00172.18 EXF73201.1 - 1.1e-08 35.1 9.3 1.7e-08 34.4 9.3 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EXF73201.1 - 0.03 13.1 0.2 0.044 12.6 0.2 1.2 1 0 0 1 1 1 0 Fungal specific transcription factor domain DUF3638 PF12340.8 EXF73202.1 - 8.8e-95 316.3 0.2 1.9e-94 315.3 0.2 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3638) DUF3645 PF12359.8 EXF73202.1 - 3.7e-17 61.4 0.2 7.7e-17 60.4 0.2 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3645) NmrA PF05368.13 EXF73203.1 - 1.7e-35 122.7 0.3 2.9e-35 121.9 0.3 1.3 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EXF73203.1 - 1.3e-13 51.2 0.4 3.1e-13 50.0 0.4 1.7 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EXF73203.1 - 0.0024 17.4 0.0 0.0046 16.4 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EXF73203.1 - 0.034 13.1 0.1 0.052 12.6 0.1 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family SMC_N PF02463.19 EXF73204.1 - 2.1e-73 246.4 19.6 1.3e-72 243.8 19.6 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EXF73204.1 - 1.8e-24 86.3 0.0 7.8e-24 84.2 0.0 2.2 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 EXF73204.1 - 9.4e-12 45.3 4.6 4.5e-05 23.4 0.4 3.7 3 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EXF73204.1 - 0.00054 19.7 0.0 0.0011 18.7 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain Filament PF00038.21 EXF73204.1 - 0.0022 17.7 43.3 0.0022 17.7 43.3 5.4 3 1 2 5 5 5 2 Intermediate filament protein CLZ PF16526.5 EXF73204.1 - 0.0091 16.3 6.6 0.0091 16.3 6.6 8.1 7 2 3 10 10 10 1 C-terminal leucine zipper domain of cyclic nucleotide-gated channels AT_hook PF02178.19 EXF73204.1 - 0.24 11.4 4.3 0.95 9.5 4.3 2.1 1 0 0 1 1 1 0 AT hook motif ABC_tran PF00005.27 EXF73204.1 - 1.1 9.8 0.0 1.1 9.8 0.0 7.0 5 2 0 5 5 5 0 ABC transporter Spc7 PF08317.11 EXF73204.1 - 6.2 5.6 126.3 0.005 15.8 27.6 7.5 3 2 4 7 7 7 0 Spc7 kinetochore protein ELYS PF13934.6 EXF73205.1 - 1.7e-69 234.2 2.5 2e-69 233.9 2.5 1.1 1 0 0 1 1 1 1 Nuclear pore complex assembly Fungal_trans PF04082.18 EXF73206.1 - 0.033 13.2 0.0 0.058 12.4 0.0 1.3 1 0 0 1 1 1 0 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF73206.1 - 0.066 13.4 4.3 0.15 12.2 4.3 1.6 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Mrx7 PF10906.8 EXF73207.1 - 3.5e-07 30.4 0.0 5e-07 29.9 0.0 1.3 1 0 0 1 1 1 1 MIOREX complex component 7 Cellulase PF00150.18 EXF73208.1 - 3.3e-27 95.6 3.3 5.6e-27 94.9 3.3 1.3 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) CBM_X2 PF03442.14 EXF73208.1 - 7.7e-23 80.4 2.3 5.2e-22 77.8 1.2 2.6 2 0 0 2 2 2 1 Carbohydrate binding domain X2 CBM_1 PF00734.18 EXF73208.1 - 1.3e-11 44.2 14.4 1.3e-11 44.2 14.4 1.8 2 0 0 2 2 2 1 Fungal cellulose binding domain SOG2 PF10428.9 EXF73208.1 - 3.1 6.9 8.7 0.08 12.1 0.7 1.9 2 0 0 2 2 2 0 RAM signalling pathway protein FAD_binding_4 PF01565.23 EXF73209.1 - 8.9e-19 67.6 3.1 4e-18 65.5 3.1 2.0 1 1 0 1 1 1 1 FAD binding domain BBE PF08031.12 EXF73209.1 - 1.2e-11 44.5 0.0 2.6e-11 43.4 0.0 1.6 1 0 0 1 1 1 1 Berberine and berberine like HET PF06985.11 EXF73210.1 - 4.3e-22 79.0 0.6 8.3e-22 78.1 0.6 1.5 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) ACT_3 PF10000.9 EXF73211.1 - 5.8e-24 83.8 0.1 8.7e-24 83.2 0.1 1.3 1 0 0 1 1 1 1 ACT domain ACT_7 PF13840.6 EXF73211.1 - 2e-08 33.9 0.0 3.4e-08 33.2 0.0 1.3 1 0 0 1 1 1 1 ACT domain Spc7 PF08317.11 EXF73213.1 - 0.007 15.3 30.9 0.056 12.3 5.0 4.3 3 1 1 4 4 4 3 Spc7 kinetochore protein AAA_13 PF13166.6 EXF73213.1 - 0.014 14.1 18.4 1.2 7.7 7.0 3.3 3 1 0 3 3 3 0 AAA domain Phage_GP20 PF06810.11 EXF73213.1 - 0.029 14.2 14.6 0.2 11.5 2.8 3.9 3 1 1 4 4 4 0 Phage minor structural protein GP20 BLOC1_2 PF10046.9 EXF73213.1 - 0.035 14.4 9.6 2.1 8.7 0.7 4.2 3 2 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF4407 PF14362.6 EXF73213.1 - 0.066 12.5 27.0 0.13 11.6 6.9 3.6 2 1 2 4 4 4 0 Domain of unknown function (DUF4407) Fib_alpha PF08702.10 EXF73213.1 - 0.085 13.0 9.7 24 5.1 1.6 4.5 3 1 1 5 5 5 0 Fibrinogen alpha/beta chain family Fez1 PF06818.15 EXF73213.1 - 0.096 13.1 29.5 1.4 9.3 8.2 4.2 2 2 2 4 4 4 0 Fez1 ATG16 PF08614.11 EXF73213.1 - 0.098 12.9 44.2 0.48 10.6 0.0 5.6 3 2 2 5 5 5 0 Autophagy protein 16 (ATG16) MPS2 PF17060.5 EXF73213.1 - 0.13 11.5 10.5 0.033 13.5 1.4 2.9 3 0 0 3 3 3 0 Monopolar spindle protein 2 DUF1664 PF07889.12 EXF73213.1 - 0.14 12.2 9.2 2.2 8.4 0.1 4.3 4 1 0 4 4 4 0 Protein of unknown function (DUF1664) UPF0242 PF06785.11 EXF73213.1 - 0.19 11.8 23.2 0.95 9.5 1.3 4.6 3 1 2 5 5 5 0 Uncharacterised protein family (UPF0242) N-terminus Filament PF00038.21 EXF73213.1 - 0.21 11.1 27.6 0.074 12.6 2.7 5.0 3 2 2 5 5 5 0 Intermediate filament protein HIP1_clath_bdg PF16515.5 EXF73213.1 - 0.3 11.7 31.7 0.83 10.3 5.6 5.7 3 2 2 5 5 5 0 Clathrin-binding domain of Huntingtin-interacting protein 1 FAM76 PF16046.5 EXF73213.1 - 0.3 10.4 12.6 0.077 12.3 0.2 3.3 3 1 1 4 4 4 0 FAM76 protein DUF2203 PF09969.9 EXF73213.1 - 0.38 11.5 21.4 4.6 8.0 1.6 4.9 4 1 1 5 5 5 0 Uncharacterized conserved protein (DUF2203) HAUS-augmin3 PF14932.6 EXF73213.1 - 0.94 9.0 16.5 2 7.9 2.9 3.4 3 1 0 3 3 3 0 HAUS augmin-like complex subunit 3 TACC_C PF05010.14 EXF73213.1 - 1.7 8.4 18.4 0.89 9.3 4.2 4.1 3 1 2 5 5 5 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal APG6_N PF17675.1 EXF73213.1 - 8 7.0 32.7 3.4 8.2 2.1 4.6 3 1 0 4 4 4 0 Apg6 coiled-coil region OTT_1508_deam PF14441.6 EXF73214.1 - 3.5e-17 62.1 0.6 3.5e-17 62.1 0.6 1.9 2 0 0 2 2 2 1 OTT_1508-like deaminase Pyr_redox_3 PF13738.6 EXF73215.1 - 4.3e-17 62.3 0.0 2.1e-16 60.0 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 EXF73215.1 - 3.4e-16 58.8 0.0 1.1e-15 57.1 0.0 1.7 1 1 1 2 2 2 1 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 EXF73215.1 - 2.6e-11 43.3 0.0 2.4e-08 33.5 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EXF73215.1 - 3.1e-11 43.0 0.0 2.4e-10 40.1 0.0 2.1 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 EXF73215.1 - 6.9e-07 29.4 0.1 2.3e-05 24.5 0.1 3.1 2 1 0 2 2 2 1 FAD-NAD(P)-binding HI0933_like PF03486.14 EXF73215.1 - 4.2e-05 22.4 0.3 0.1 11.3 0.0 2.3 2 0 0 2 2 2 2 HI0933-like protein Thi4 PF01946.17 EXF73215.1 - 8.9e-05 21.8 0.0 0.00019 20.8 0.0 1.4 1 0 0 1 1 1 1 Thi4 family NAD_binding_8 PF13450.6 EXF73215.1 - 0.00027 21.1 0.0 0.00058 20.0 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EXF73215.1 - 0.0004 20.1 0.7 0.76 9.3 0.1 2.6 2 0 0 2 2 2 2 FAD dependent oxidoreductase Amino_oxidase PF01593.24 EXF73215.1 - 0.0016 17.8 0.4 5.2 6.2 0.0 3.3 3 0 0 3 3 3 2 Flavin containing amine oxidoreductase FAD_binding_3 PF01494.19 EXF73215.1 - 0.0018 17.6 0.1 0.45 9.7 0.1 2.2 2 0 0 2 2 2 2 FAD binding domain Tyrosinase PF00264.20 EXF73216.1 - 1.3e-35 123.7 0.0 1.8e-35 123.2 0.0 1.2 1 0 0 1 1 1 1 Common central domain of tyrosinase FGFR3_TM PF18123.1 EXF73217.1 - 0.16 11.5 2.0 0.64 9.6 2.0 2.0 1 0 0 1 1 1 0 Fibroblast growth factor receptor 3 transmembrane domain Tyrosinase PF00264.20 EXF73218.1 - 4.6e-39 135.0 0.6 6.4e-39 134.5 0.6 1.2 1 0 0 1 1 1 1 Common central domain of tyrosinase HMG_box PF00505.19 EXF73218.1 - 0.092 13.2 0.0 0.16 12.4 0.0 1.3 1 0 0 1 1 1 0 HMG (high mobility group) box CorA PF01544.18 EXF73219.1 - 4.3e-07 29.6 0.0 1e-06 28.3 0.0 1.6 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein DUF3425 PF11905.8 EXF73220.1 - 1.1e-17 64.2 0.0 3.2e-17 62.6 0.0 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF3425) adh_short PF00106.25 EXF73221.1 - 1.3e-23 83.5 0.0 5.1e-21 75.0 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EXF73221.1 - 3.4e-13 49.7 0.0 1.5e-12 47.6 0.0 1.8 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF73221.1 - 8.4e-10 38.8 0.0 1.3e-09 38.2 0.0 1.3 1 0 0 1 1 1 1 KR domain GDP_Man_Dehyd PF16363.5 EXF73221.1 - 0.00021 20.8 0.0 0.0012 18.3 0.1 1.9 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 EXF73221.1 - 0.0029 17.1 0.0 0.0076 15.7 0.0 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family adh_short PF00106.25 EXF73222.1 - 1.7e-45 154.9 0.4 2.2e-45 154.5 0.4 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF73222.1 - 8.6e-32 110.6 0.2 1.2e-31 110.1 0.2 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 EXF73222.1 - 0.00046 19.7 0.1 0.00082 18.9 0.1 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family TrkA_N PF02254.18 EXF73222.1 - 0.008 16.4 0.0 0.016 15.4 0.0 1.5 1 0 0 1 1 1 1 TrkA-N domain RT_RNaseH_2 PF17919.1 EXF73222.1 - 0.013 15.6 0.0 0.05 13.6 0.0 2.0 2 0 0 2 2 2 0 RNase H-like domain found in reverse transcriptase RmlD_sub_bind PF04321.17 EXF73222.1 - 0.047 12.8 0.0 0.069 12.2 0.0 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain DUF1776 PF08643.10 EXF73222.1 - 0.052 12.9 0.0 0.059 12.7 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) 2-Hacid_dh_C PF02826.19 EXF73222.1 - 0.059 12.7 0.0 0.11 11.9 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ADH_zinc_N PF00107.26 EXF73222.1 - 0.064 13.2 0.2 0.14 12.1 0.2 1.6 1 0 0 1 1 1 0 Zinc-binding dehydrogenase FtsJ PF01728.19 EXF73222.1 - 0.075 13.1 0.0 0.11 12.6 0.0 1.2 1 0 0 1 1 1 0 FtsJ-like methyltransferase MFS_1 PF07690.16 EXF73223.1 - 1.7e-39 135.8 49.1 3.6e-39 134.7 49.1 1.8 1 1 0 1 1 1 1 Major Facilitator Superfamily OATP PF03137.20 EXF73223.1 - 0.00049 18.5 5.4 0.00049 18.5 5.4 2.7 2 1 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family DUF2919 PF11143.8 EXF73223.1 - 0.066 13.5 4.1 0.6 10.4 0.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2919) ketoacyl-synt PF00109.26 EXF73224.1 - 1e-72 244.8 0.5 2.3e-72 243.6 0.1 1.9 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.10 EXF73224.1 - 2.4e-47 161.2 0.0 5.5e-47 160.0 0.0 1.7 1 0 0 1 1 1 1 KR domain PS-DH PF14765.6 EXF73224.1 - 9e-44 149.9 0.0 5.7e-43 147.2 0.0 2.0 1 1 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 EXF73224.1 - 1.2e-43 149.8 0.2 2.2e-43 149.0 0.2 1.4 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EXF73224.1 - 3.1e-30 104.6 0.1 1.1e-29 102.9 0.1 2.0 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Methyltransf_12 PF08242.12 EXF73224.1 - 6e-18 65.4 0.0 1.6e-17 64.0 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain KAsynt_C_assoc PF16197.5 EXF73224.1 - 1.6e-14 54.3 0.0 5.4e-14 52.6 0.0 2.0 2 0 0 2 2 1 1 Ketoacyl-synthetase C-terminal extension adh_short PF00106.25 EXF73224.1 - 9.6e-13 48.0 0.0 2.5e-12 46.6 0.0 1.7 1 0 0 1 1 1 1 short chain dehydrogenase Methyltransf_25 PF13649.6 EXF73224.1 - 3.2e-12 47.0 0.0 5.6e-10 39.8 0.0 3.4 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF73224.1 - 1.7e-10 41.4 0.0 6e-10 39.6 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EXF73224.1 - 1.6e-09 37.8 0.0 4e-09 36.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF73224.1 - 9.5e-09 35.2 0.0 2.4e-08 33.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PP-binding PF00550.25 EXF73224.1 - 1.1e-08 35.4 0.6 4.4e-08 33.3 0.1 2.3 2 0 0 2 2 2 1 Phosphopantetheine attachment site adh_short_C2 PF13561.6 EXF73224.1 - 7.7e-08 32.2 0.0 2.1e-07 30.7 0.0 1.7 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Thiolase_N PF00108.23 EXF73224.1 - 4.1e-05 23.1 0.5 4.1e-05 23.1 0.5 1.9 2 0 0 2 2 2 1 Thiolase, N-terminal domain Ubie_methyltran PF01209.18 EXF73224.1 - 0.00035 20.0 0.0 0.00081 18.8 0.0 1.5 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family DUF938 PF06080.12 EXF73224.1 - 0.045 13.5 0.0 0.1 12.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF938) Methyltransf_16 PF10294.9 EXF73224.1 - 0.12 12.2 0.0 0.34 10.6 0.0 1.7 2 0 0 2 2 2 0 Lysine methyltransferase p450 PF00067.22 EXF73225.1 - 2.3e-66 224.5 0.0 3.1e-66 224.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 ADH_zinc_N PF00107.26 EXF73226.1 - 1.5e-11 44.4 0.0 5.2e-11 42.6 0.0 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EXF73226.1 - 0.00081 19.3 0.6 0.0019 18.0 0.3 1.7 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain Aldose_epim PF01263.20 EXF73227.1 - 7.4e-18 64.9 0.1 6.5e-13 48.7 0.0 2.6 2 1 0 2 2 2 2 Aldose 1-epimerase DXP_redisom_C PF08436.12 EXF73227.1 - 0.087 13.0 0.1 0.19 11.9 0.1 1.6 1 0 0 1 1 1 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal domain FSH1 PF03959.13 EXF73228.1 - 2.3e-21 76.4 0.0 3e-21 76.1 0.0 1.1 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Zn_clus PF00172.18 EXF73229.1 - 8.3e-06 25.8 9.2 1.4e-05 25.1 9.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.16 EXF73230.1 - 1.9e-21 76.4 30.8 4.4e-11 42.3 9.7 2.7 1 1 2 3 3 3 3 Major Facilitator Superfamily DUF2561 PF10812.8 EXF73230.1 - 0.023 14.7 1.2 6.3 6.8 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2561) Amnionless PF14828.6 EXF73230.1 - 0.031 13.1 0.1 5.3 5.7 0.0 2.1 2 0 0 2 2 2 0 Amnionless DUF4834 PF16118.5 EXF73230.1 - 1.3 10.0 4.8 21 6.2 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) SurA_N_3 PF13624.6 EXF73230.1 - 2.2 8.0 4.0 1.1 9.0 0.0 2.1 2 0 0 2 2 2 0 SurA N-terminal domain Glyco_hydro_31 PF01055.26 EXF73231.1 - 8.2e-87 292.2 0.7 1e-86 291.9 0.7 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 EXF73231.1 - 5.5e-13 49.0 0.1 1e-11 45.0 0.0 2.9 2 1 1 3 3 3 1 Galactose mutarotase-like CN_hydrolase PF00795.22 EXF73233.1 - 1.7e-17 63.6 0.0 1.3e-08 34.5 0.0 2.1 2 0 0 2 2 2 2 Carbon-nitrogen hydrolase Peptidase_S10 PF00450.22 EXF73234.1 - 1.8e-102 343.9 3.1 2.1e-102 343.7 3.1 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase BetaGal_dom4_5 PF13364.6 EXF73234.1 - 0.014 15.9 0.3 0.048 14.2 0.1 2.0 2 0 0 2 2 2 0 Beta-galactosidase jelly roll domain Dynamin_N PF00350.23 EXF73235.1 - 2.3e-32 112.4 0.1 3.7e-32 111.7 0.1 1.3 1 0 0 1 1 1 1 Dynamin family Dynamin_M PF01031.20 EXF73235.1 - 1.5e-16 60.5 0.0 1.4e-14 54.0 0.0 2.3 2 0 0 2 2 2 1 Dynamin central region MMR_HSR1 PF01926.23 EXF73235.1 - 2.3e-06 27.7 0.1 1.9e-05 24.7 0.1 2.4 2 1 0 2 2 2 1 50S ribosome-binding GTPase GED PF02212.18 EXF73235.1 - 0.0051 16.9 1.6 0.0091 16.1 0.5 2.0 2 0 0 2 2 2 1 Dynamin GTPase effector domain AAA_21 PF13304.6 EXF73235.1 - 0.011 15.5 0.0 0.025 14.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system FeoB_N PF02421.18 EXF73235.1 - 0.013 15.0 0.0 1.7 8.1 0.0 2.3 2 0 0 2 2 2 0 Ferrous iron transport protein B AAA_23 PF13476.6 EXF73235.1 - 0.016 15.7 0.3 0.087 13.3 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_15 PF13175.6 EXF73235.1 - 0.027 14.2 0.1 0.061 13.0 0.0 1.7 2 0 0 2 2 2 0 AAA ATPase domain Roc PF08477.13 EXF73235.1 - 0.062 13.5 0.0 0.89 9.8 0.0 2.2 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.6 EXF73235.1 - 0.1 12.3 0.0 0.23 11.2 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain SMC_N PF02463.19 EXF73235.1 - 0.12 11.8 0.0 0.22 10.9 0.0 1.3 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain Cation_ATPase_C PF00689.21 EXF73236.1 - 1.1e-26 93.6 5.3 2e-26 92.8 5.3 1.4 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 EXF73236.1 - 3e-15 57.1 0.0 4.1e-15 56.6 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EXF73236.1 - 9.6e-14 51.2 0.0 1.7e-13 50.4 0.0 1.4 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EXF73236.1 - 0.0045 16.8 0.4 0.0087 15.8 0.4 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 EXF73237.1 - 4.5e-37 127.3 1.7 3.1e-36 124.6 1.8 1.9 2 0 0 2 2 2 1 E1-E2 ATPase MgtE PF01769.16 EXF73237.1 - 0.51 10.7 7.1 4.8 7.6 6.1 2.2 2 0 0 2 2 2 0 Divalent cation transporter Phage_holin_3_6 PF07332.11 EXF73237.1 - 3.1 7.8 10.4 1.2 9.2 5.7 2.2 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III DUF1933 PF09147.10 EXF73239.1 - 0.093 12.3 0.0 0.23 11.1 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1933) DUF2663 PF10864.8 EXF73241.1 - 0.027 14.8 0.9 0.72 10.3 0.0 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF2663) Ac76 PF05814.11 EXF73241.1 - 0.066 13.2 1.1 1.5 8.9 0.0 3.0 2 1 1 3 3 3 0 Orf76 (Ac76) TctB PF07331.11 EXF73241.1 - 0.58 10.4 5.5 0.24 11.6 0.3 2.3 2 1 0 2 2 2 0 Tripartite tricarboxylate transporter TctB family DUF1218 PF06749.12 EXF73241.1 - 0.77 10.3 3.7 2.9 8.5 1.2 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF1218) DUF3817 PF12823.7 EXF73241.1 - 5.7 7.8 6.5 1.2 10.0 0.1 2.8 3 1 0 3 3 3 0 Domain of unknown function (DUF3817) Frizzled PF01534.17 EXF73242.1 - 0.029 13.4 0.0 0.079 12.0 0.0 1.7 2 0 0 2 2 2 0 Frizzled/Smoothened family membrane region Phage_holin_8 PF16931.5 EXF73242.1 - 0.058 13.4 0.6 14 5.7 0.0 3.9 3 1 1 4 4 4 0 Putative phage holin DUF1761 PF08570.10 EXF73242.1 - 0.18 12.1 5.7 3.9 7.8 1.7 3.2 2 1 0 2 2 2 0 Protein of unknown function (DUF1761) DUF4027 PF13219.6 EXF73242.1 - 0.19 11.6 1.6 0.36 10.7 0.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4027) Otopetrin PF03189.13 EXF73242.1 - 0.2 10.4 1.3 0.63 8.8 0.1 2.0 1 1 1 2 2 2 0 Otopetrin DUF4064 PF13273.6 EXF73242.1 - 2.3 8.5 6.0 16 5.8 0.0 3.7 3 2 0 3 3 3 0 Protein of unknown function (DUF4064) DUF3335 PF11814.8 EXF73243.1 - 0.14 11.6 0.0 0.25 10.8 0.0 1.3 1 1 0 1 1 1 0 Peptidase_C39 like family MU117 PF15474.6 EXF73244.1 - 1.3e-18 67.7 8.6 1.6e-18 67.3 8.6 1.1 1 0 0 1 1 1 1 Meiotically up-regulated gene family Kp4 PF09044.10 EXF73244.1 - 0.11 12.6 7.5 0.21 11.7 7.5 1.4 1 1 0 1 1 1 0 Kp4 Pkinase PF00069.25 EXF73245.1 - 8.6e-39 133.5 0.0 1.3e-38 132.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF73245.1 - 9.4e-21 74.3 0.0 1.4e-20 73.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EXF73245.1 - 7.2e-06 25.5 0.0 0.00061 19.2 0.0 2.3 2 0 0 2 2 2 2 Kinase-like APH PF01636.23 EXF73245.1 - 0.012 15.5 0.0 0.043 13.7 0.0 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family SUR7 PF06687.12 EXF73247.1 - 2.5e-15 56.7 2.5 3.2e-15 56.3 2.5 1.1 1 0 0 1 1 1 1 SUR7/PalI family DUF2070 PF09843.9 EXF73247.1 - 0.76 8.0 14.6 1.2 7.4 14.6 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Turandot PF07240.11 EXF73248.1 - 0.078 13.0 0.0 4.1 7.4 0.0 2.9 3 0 0 3 3 3 0 Stress-inducible humoral factor Turandot PUA_3 PF17785.1 EXF73249.1 - 0.046 13.5 0.0 0.11 12.3 0.0 1.6 1 0 0 1 1 1 0 PUA-like domain Glyco_hydro_71 PF03659.14 EXF73250.1 - 1.7e-138 461.6 2.5 1.7e-138 461.6 2.5 1.5 2 0 0 2 2 2 1 Glycosyl hydrolase family 71 Acetyltransf_10 PF13673.7 EXF73251.1 - 4.1e-08 33.2 0.0 1.4e-07 31.5 0.0 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EXF73251.1 - 5.1e-08 33.2 0.0 8.3e-08 32.5 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EXF73251.1 - 1.2e-06 28.8 0.0 4.7e-06 26.9 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EXF73251.1 - 0.061 13.4 0.0 0.57 10.3 0.0 2.1 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain DUF2207 PF09972.9 EXF73252.1 - 0.13 11.0 0.3 0.19 10.4 0.1 1.3 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF543 PF04418.12 EXF73252.1 - 0.17 11.9 1.0 0.31 11.0 1.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF543) JAB PF01398.21 EXF73253.1 - 1.8e-14 53.7 0.0 3.6e-14 52.7 0.0 1.5 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.6 EXF73253.1 - 1.2e-05 25.1 0.0 3e-05 23.8 0.0 1.7 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain USP8_dimer PF08969.11 EXF73253.1 - 1.6e-05 25.1 0.0 3.4e-05 24.0 0.0 1.5 1 0 0 1 1 1 1 USP8 dimerisation domain DUF334 PF03904.13 EXF73253.1 - 0.15 11.6 0.1 0.23 11.0 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF334) DUF2884 PF11101.8 EXF73254.1 - 0.082 12.4 0.1 0.1 12.1 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2884) DUF3969 PF13108.6 EXF73254.1 - 0.15 12.1 0.0 0.25 11.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3969) Prefoldin_2 PF01920.20 EXF73255.1 - 1.9e-19 69.6 13.2 2.5e-19 69.2 13.2 1.2 1 0 0 1 1 1 1 Prefoldin subunit Prefoldin_3 PF13758.6 EXF73255.1 - 0.007 16.4 5.0 0.0099 15.9 5.0 1.3 1 0 0 1 1 1 1 Prefoldin subunit Herpes_BLRF2 PF05812.12 EXF73255.1 - 0.043 13.9 5.3 0.087 13.0 5.1 1.6 1 1 0 1 1 1 0 Herpesvirus BLRF2 protein Terminase_4 PF05119.12 EXF73255.1 - 0.045 14.2 5.9 0.9 10.0 0.7 2.2 2 0 0 2 2 2 0 Phage terminase, small subunit MREG PF15812.5 EXF73255.1 - 0.053 13.8 0.8 0.093 13.0 0.5 1.5 1 1 0 1 1 1 0 Melanoregulin JIP_LZII PF16471.5 EXF73255.1 - 0.061 13.5 3.0 0.061 13.5 3.0 2.1 2 2 0 2 2 2 0 JNK-interacting protein leucine zipper II Rx_N PF18052.1 EXF73255.1 - 0.097 13.0 8.7 1.5 9.1 3.5 2.2 2 0 0 2 2 2 0 Rx N-terminal domain SPX PF03105.19 EXF73255.1 - 0.12 12.3 4.1 0.13 12.2 4.1 1.0 1 0 0 1 1 1 0 SPX domain PHM7_cyt PF14703.6 EXF73255.1 - 0.17 12.1 8.8 0.39 10.9 8.8 1.6 1 1 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter Spc7 PF08317.11 EXF73255.1 - 0.26 10.1 16.5 1 8.1 16.5 1.8 1 1 0 1 1 1 0 Spc7 kinetochore protein DUF4201 PF13870.6 EXF73255.1 - 0.47 10.2 12.4 1.5 8.5 0.6 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) TMPIT PF07851.13 EXF73255.1 - 0.9 8.7 7.4 1.1 8.4 7.4 1.2 1 0 0 1 1 1 0 TMPIT-like protein SKA2 PF16740.5 EXF73255.1 - 1.2 9.0 9.9 0.19 11.5 3.9 2.1 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 2 FlaC_arch PF05377.11 EXF73255.1 - 1.3 9.5 6.6 13 6.2 2.6 3.1 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) Prefoldin PF02996.17 EXF73255.1 - 1.7 8.6 12.7 2.3 8.1 0.6 2.8 1 1 2 3 3 3 0 Prefoldin subunit DUF4407 PF14362.6 EXF73255.1 - 2.4 7.5 11.3 2.8 7.2 11.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Spc24 PF08286.11 EXF73255.1 - 6.3 7.1 12.5 4.4 7.6 5.6 2.1 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 ABC_tran_CTD PF16326.5 EXF73255.1 - 6.4 7.1 13.6 0.9 9.8 3.4 2.6 2 1 0 2 2 2 0 ABC transporter C-terminal domain AAA PF00004.29 EXF73256.1 - 4.3e-42 143.7 0.0 7.9e-42 142.8 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 EXF73256.1 - 4.1e-26 90.8 0.1 1.4e-25 89.0 0.1 2.0 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain MIT PF04212.18 EXF73256.1 - 4.2e-23 81.2 1.7 1e-22 80.0 1.7 1.7 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain AAA_lid_3 PF17862.1 EXF73256.1 - 6.9e-07 29.0 0.0 2.2e-06 27.4 0.0 1.8 1 0 0 1 1 1 1 AAA+ lid domain RuvB_N PF05496.12 EXF73256.1 - 1e-06 28.6 0.0 1.8e-06 27.8 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain TIP49 PF06068.13 EXF73256.1 - 1.3e-05 24.6 0.0 3.1e-05 23.4 0.0 1.6 1 1 1 2 2 2 1 TIP49 P-loop domain AAA_16 PF13191.6 EXF73256.1 - 1.6e-05 25.3 0.0 0.00049 20.5 0.0 2.7 1 1 0 1 1 1 1 AAA ATPase domain IstB_IS21 PF01695.17 EXF73256.1 - 2.6e-05 24.1 0.0 5e-05 23.1 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein RNA_helicase PF00910.22 EXF73256.1 - 6.3e-05 23.3 0.0 0.012 16.0 0.0 2.7 2 0 0 2 2 2 1 RNA helicase AAA_5 PF07728.14 EXF73256.1 - 7.7e-05 22.7 0.0 0.00034 20.6 0.0 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EXF73256.1 - 0.00011 22.5 0.1 0.0084 16.4 0.1 2.7 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.6 EXF73256.1 - 0.00017 21.7 0.0 0.00043 20.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain DUF815 PF05673.13 EXF73256.1 - 0.00043 19.5 0.0 0.011 14.9 0.0 2.2 1 1 1 2 2 2 1 Protein of unknown function (DUF815) AAA_18 PF13238.6 EXF73256.1 - 0.00074 20.1 0.0 0.0023 18.5 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.6 EXF73256.1 - 0.0026 17.5 0.0 0.0068 16.2 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EXF73256.1 - 0.0028 17.8 0.0 0.0066 16.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 EXF73256.1 - 0.0048 17.3 0.0 0.048 14.1 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_2 PF07724.14 EXF73256.1 - 0.0089 16.2 0.0 0.037 14.2 0.0 1.9 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) NACHT PF05729.12 EXF73256.1 - 0.02 14.8 0.0 0.75 9.7 0.0 2.3 1 1 1 2 2 2 0 NACHT domain AAA_7 PF12775.7 EXF73256.1 - 0.026 14.0 0.1 0.12 11.9 0.0 2.2 2 1 0 2 2 2 0 P-loop containing dynein motor region AAA_25 PF13481.6 EXF73256.1 - 0.027 14.1 0.1 0.35 10.4 0.1 2.3 1 1 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 EXF73256.1 - 0.028 13.8 0.0 0.08 12.3 0.0 1.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI PhoH PF02562.16 EXF73256.1 - 0.058 12.8 0.2 0.15 11.5 0.1 1.6 2 0 0 2 2 2 0 PhoH-like protein AAA_21 PF13304.6 EXF73256.1 - 0.072 12.9 0.1 8.1 6.2 0.0 2.3 1 1 1 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system Torsin PF06309.11 EXF73256.1 - 0.086 12.9 0.0 0.17 12.0 0.0 1.5 1 0 0 1 1 1 0 Torsin Parvo_NS1 PF01057.17 EXF73256.1 - 0.11 11.6 0.0 0.18 10.9 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Bac_DnaA PF00308.18 EXF73256.1 - 0.11 12.3 0.0 0.46 10.3 0.0 1.8 1 1 0 1 1 1 0 Bacterial dnaA protein Cytidylate_kin PF02224.18 EXF73256.1 - 0.11 12.2 0.3 0.52 10.0 0.1 2.2 3 0 0 3 3 2 0 Cytidylate kinase Sigma54_activat PF00158.26 EXF73256.1 - 0.13 11.9 0.0 0.42 10.3 0.0 1.8 1 1 0 1 1 1 0 Sigma-54 interaction domain ATPase PF06745.13 EXF73256.1 - 0.16 11.3 0.0 5.5 6.3 0.0 2.3 1 1 1 2 2 2 0 KaiC TniB PF05621.11 EXF73256.1 - 0.17 11.3 0.0 13 5.2 0.0 2.5 1 1 0 2 2 2 0 Bacterial TniB protein Nop PF01798.18 EXF73257.1 - 3.3e-81 272.1 0.1 3.3e-81 272.1 0.1 1.7 2 0 0 2 2 2 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 EXF73257.1 - 2.4e-17 63.1 0.0 2.4e-17 63.1 0.0 2.5 3 0 0 3 3 3 1 NOP5NT (NUC127) domain RNA_polI_A34 PF08208.11 EXF73257.1 - 0.24 11.5 26.3 0.41 10.7 26.3 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 TRAM_LAG1_CLN8 PF03798.16 EXF73258.1 - 4.5e-35 121.2 19.6 4.5e-35 121.2 19.6 1.6 2 0 0 2 2 2 1 TLC domain TRAM1 PF08390.11 EXF73258.1 - 2.7e-25 87.8 0.0 6.3e-25 86.6 0.0 1.7 1 0 0 1 1 1 1 TRAM1-like protein Glyco_hydro_18 PF00704.28 EXF73259.1 - 1.2e-84 284.8 0.1 1.3e-84 284.6 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 DUF4766 PF15973.5 EXF73259.1 - 0.2 12.2 0.6 0.35 11.5 0.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4766) Ribosomal_S27 PF01599.19 EXF73260.1 - 1.4e-26 92.4 1.8 1.4e-26 92.4 1.8 1.9 2 0 0 2 2 2 1 Ribosomal protein S27a ubiquitin PF00240.23 EXF73260.1 - 4.8e-18 64.7 0.1 1.1e-17 63.5 0.1 1.7 2 0 0 2 2 2 1 Ubiquitin family Rad60-SLD PF11976.8 EXF73260.1 - 1.5e-07 31.1 0.0 3.7e-07 29.9 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD_2 PF13881.6 EXF73260.1 - 0.0066 16.5 0.1 0.009 16.1 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Abhydrolase_1 PF00561.20 EXF73261.1 - 1.5e-20 73.9 0.0 1.3e-18 67.6 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EXF73261.1 - 4.8e-12 47.0 0.1 5.9e-12 46.7 0.1 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EXF73261.1 - 2.6e-09 36.7 0.2 5.9e-09 35.5 0.2 1.6 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Esterase PF00756.20 EXF73261.1 - 0.00035 20.3 0.0 0.00045 19.9 0.0 1.2 1 0 0 1 1 1 1 Putative esterase Thioesterase PF00975.20 EXF73261.1 - 0.0092 16.1 0.0 0.014 15.5 0.0 1.2 1 0 0 1 1 1 1 Thioesterase domain PGAP1 PF07819.13 EXF73261.1 - 0.011 15.5 0.0 0.014 15.1 0.0 1.2 1 0 0 1 1 1 0 PGAP1-like protein Adhes-Ig_like PF09085.10 EXF73261.1 - 0.057 13.6 0.0 0.091 12.9 0.0 1.3 1 0 0 1 1 1 0 Adhesion molecule, immunoglobulin-like Ndr PF03096.14 EXF73261.1 - 0.12 11.0 0.0 0.2 10.3 0.0 1.2 1 0 0 1 1 1 0 Ndr family Ribosomal_S3Ae PF01015.18 EXF73262.1 - 1.1e-89 299.3 2.5 1.4e-89 299.1 2.5 1.1 1 0 0 1 1 1 1 Ribosomal S3Ae family SUI1 PF01253.22 EXF73262.1 - 0.024 15.2 0.2 0.08 13.5 0.0 2.0 2 0 0 2 2 2 0 Translation initiation factor SUI1 NEMO PF11577.8 EXF73262.1 - 0.066 13.2 0.8 0.43 10.6 0.0 2.4 2 0 0 2 2 2 0 NF-kappa-B essential modulator NEMO TipAS PF07739.13 EXF73262.1 - 0.15 12.6 0.0 2.2 8.9 0.0 2.5 2 1 1 3 3 3 0 TipAS antibiotic-recognition domain GTP_CH_N PF12471.8 EXF73264.1 - 5.7e-85 284.0 0.0 7.8e-85 283.5 0.0 1.2 1 0 0 1 1 1 1 GTP cyclohydrolase N terminal GTP_cyclohydro2 PF00925.20 EXF73264.1 - 7.8e-16 58.1 0.0 1.2e-15 57.4 0.0 1.3 1 0 0 1 1 1 1 GTP cyclohydrolase II 53-BP1_Tudor PF09038.10 EXF73264.1 - 0.089 12.7 0.0 0.2 11.6 0.0 1.5 2 0 0 2 2 2 0 Tumour suppressor p53-binding protein-1 Tudor DUF4644 PF15486.6 EXF73264.1 - 0.46 10.2 2.2 0.81 9.4 2.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4644) Elf1 PF05129.13 EXF73265.1 - 1.7e-28 98.5 0.2 2.1e-28 98.2 0.2 1.1 1 0 0 1 1 1 1 Transcription elongation factor Elf1 like PHD_4 PF16866.5 EXF73265.1 - 0.046 13.8 0.4 0.074 13.2 0.4 1.3 1 0 0 1 1 1 0 PHD-finger UPRTase PF14681.6 EXF73266.1 - 1.6e-80 269.5 0.0 1.8e-80 269.2 0.0 1.0 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.27 EXF73266.1 - 0.0034 16.9 0.0 0.005 16.4 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain WAPL PF07814.13 EXF73267.1 - 1.3e-56 192.0 0.0 1.8e-56 191.5 0.0 1.1 1 0 0 1 1 1 1 Wings apart-like protein regulation of heterochromatin Ras PF00071.22 EXF73267.1 - 3.2e-42 143.9 0.0 5.3e-42 143.2 0.0 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EXF73267.1 - 2.1e-12 47.3 0.0 3.8e-12 46.5 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EXF73267.1 - 3.9e-05 23.2 0.0 5.8e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EXF73267.1 - 0.00029 20.4 0.0 0.00061 19.4 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Peptidase_C78 PF07910.13 EXF73268.1 - 1.7e-68 230.2 0.0 2.3e-68 229.8 0.0 1.2 1 0 0 1 1 1 1 Peptidase family C78 Hist_deacetyl PF00850.19 EXF73268.1 - 0.0083 15.6 0.0 0.012 15.2 0.0 1.2 1 0 0 1 1 1 1 Histone deacetylase domain zf-Di19 PF05605.12 EXF73268.1 - 0.014 15.7 0.4 0.042 14.2 0.1 2.0 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding PRP21_like_P PF12230.8 EXF73268.1 - 0.15 11.9 0.3 0.37 10.6 0.1 1.7 1 1 0 2 2 2 0 Pre-mRNA splicing factor PRP21 like protein Ham1p_like PF01725.16 EXF73269.1 - 3.8e-56 190.0 0.0 9.2e-56 188.7 0.0 1.6 2 0 0 2 2 2 1 Ham1 family AAA_18 PF13238.6 EXF73269.1 - 9.7e-29 100.5 0.0 1.7e-28 99.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 EXF73269.1 - 1.5e-07 31.9 0.0 5.6e-07 30.1 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EXF73269.1 - 3e-05 24.2 0.0 0.0054 16.9 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 EXF73269.1 - 0.00011 22.7 0.0 0.0053 17.2 0.0 2.4 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 EXF73269.1 - 0.00019 21.7 0.1 0.00099 19.4 0.0 2.1 2 0 0 2 2 2 1 AAA domain ADK PF00406.22 EXF73269.1 - 0.00035 20.7 0.0 0.011 15.9 0.0 2.2 2 0 0 2 2 2 1 Adenylate kinase Hydin_ADK PF17213.3 EXF73269.1 - 0.0018 18.6 0.0 0.004 17.5 0.0 1.5 1 0 0 1 1 1 1 Hydin Adenylate kinase-like domain Thymidylate_kin PF02223.17 EXF73269.1 - 0.0031 17.2 0.3 2.2 7.9 0.0 2.2 2 0 0 2 2 2 2 Thymidylate kinase NTPase_1 PF03266.15 EXF73269.1 - 0.0038 17.2 0.1 0.009 15.9 0.1 1.6 1 0 0 1 1 1 1 NTPase AAA_22 PF13401.6 EXF73269.1 - 0.0043 17.3 0.2 0.012 15.9 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EXF73269.1 - 0.0043 17.4 0.2 0.013 15.9 0.2 1.9 1 1 0 1 1 1 1 AAA ATPase domain RNA_helicase PF00910.22 EXF73269.1 - 0.014 15.8 0.1 0.15 12.5 0.0 2.3 2 0 0 2 2 2 0 RNA helicase Viral_helicase1 PF01443.18 EXF73269.1 - 0.018 14.8 0.0 0.036 13.8 0.0 1.5 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase SKI PF01202.22 EXF73269.1 - 0.02 15.0 0.0 6.7 6.8 0.0 2.2 2 0 0 2 2 2 0 Shikimate kinase KTI12 PF08433.10 EXF73269.1 - 0.024 14.1 0.0 0.056 12.9 0.0 1.6 2 0 0 2 2 2 0 Chromatin associated protein KTI12 dNK PF01712.19 EXF73269.1 - 0.064 13.1 0.2 4.1 7.2 0.0 2.3 1 1 0 2 2 2 0 Deoxynucleoside kinase AAA_5 PF07728.14 EXF73269.1 - 0.083 12.9 0.0 0.16 11.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) FSIP2 PF15783.5 EXF73269.1 - 0.084 10.8 0.2 0.11 10.4 0.2 1.1 1 0 0 1 1 1 0 Fibrous sheath-interacting protein 2 AAA_19 PF13245.6 EXF73269.1 - 0.085 13.2 1.1 0.45 10.9 0.0 2.4 2 1 0 2 2 2 0 AAA domain SRP54 PF00448.22 EXF73269.1 - 0.11 12.1 0.0 0.19 11.3 0.0 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_24 PF13479.6 EXF73269.1 - 0.11 12.2 0.0 0.25 11.1 0.0 1.6 2 0 0 2 2 1 0 AAA domain FtsK_SpoIIIE PF01580.18 EXF73269.1 - 0.12 11.7 0.4 3.1 7.1 0.0 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family ATP_bind_1 PF03029.17 EXF73269.1 - 0.14 12.0 0.1 0.27 11.0 0.1 1.5 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein Rad17 PF03215.15 EXF73269.1 - 0.15 12.0 0.0 0.33 10.9 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain Myosin_head PF00063.21 EXF73270.1 - 1.1e-258 860.0 0.1 1.9e-258 859.2 0.1 1.4 1 0 0 1 1 1 1 Myosin head (motor domain) DIL PF01843.19 EXF73270.1 - 2.5e-26 92.0 2.7 2.5e-26 92.0 2.7 2.8 2 0 0 2 2 2 1 DIL domain IQ PF00612.27 EXF73270.1 - 1.1e-19 68.3 31.8 3.8e-05 23.1 1.8 6.9 6 0 0 6 6 6 5 IQ calmodulin-binding motif Myosin_N PF02736.19 EXF73270.1 - 0.00036 20.3 2.6 0.00036 20.3 2.6 2.0 2 0 0 2 2 2 1 Myosin N-terminal SH3-like domain GAS PF13851.6 EXF73270.1 - 0.00044 19.7 29.7 0.00063 19.2 14.7 2.7 1 1 1 2 2 2 1 Growth-arrest specific micro-tubule binding AAA_16 PF13191.6 EXF73270.1 - 0.0024 18.3 0.6 0.0098 16.3 0.0 2.4 2 0 0 2 2 1 1 AAA ATPase domain AAA_22 PF13401.6 EXF73270.1 - 0.0028 18.0 0.0 0.014 15.7 0.0 2.2 1 0 0 1 1 1 1 AAA domain CALCOCO1 PF07888.11 EXF73270.1 - 0.0029 16.5 25.8 0.0057 15.6 25.8 1.4 1 0 0 1 1 1 1 Calcium binding and coiled-coil domain (CALCOCO1) like FlaC_arch PF05377.11 EXF73270.1 - 0.038 14.4 0.2 0.038 14.4 0.2 4.4 4 0 0 4 4 4 0 Flagella accessory protein C (FlaC) Baculo_PEP_C PF04513.12 EXF73270.1 - 0.084 12.9 13.6 0.042 13.9 6.5 2.8 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus AAA_13 PF13166.6 EXF73270.1 - 0.093 11.4 14.4 0.2 10.2 14.4 1.5 1 0 0 1 1 1 0 AAA domain TMF_TATA_bd PF12325.8 EXF73270.1 - 0.23 11.7 24.9 0.29 11.4 8.4 3.4 1 1 2 3 3 3 0 TATA element modulatory factor 1 TATA binding Leu_zip PF15294.6 EXF73270.1 - 0.5 9.8 20.3 2 7.8 20.2 2.0 1 1 0 1 1 1 0 Leucine zipper DUF5407 PF17401.2 EXF73270.1 - 0.57 10.5 2.4 1.2 9.4 1.1 2.3 2 0 0 2 2 1 0 Family of unknown function (DUF5407) Sec34 PF04136.15 EXF73270.1 - 0.6 10.0 14.1 0.17 11.8 4.3 2.6 1 1 1 2 2 2 0 Sec34-like family DUF812 PF05667.11 EXF73270.1 - 0.73 8.6 28.6 2.7 6.8 28.5 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF812) ABC_tran PF00005.27 EXF73270.1 - 0.86 10.1 4.1 1.9 9.0 0.0 3.0 2 0 0 2 2 2 0 ABC transporter Phage_GP20 PF06810.11 EXF73270.1 - 0.91 9.3 17.1 0.091 12.6 3.1 3.3 1 1 2 3 3 3 0 Phage minor structural protein GP20 DUF3450 PF11932.8 EXF73270.1 - 1 8.6 29.5 1.6 8.0 15.0 2.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) ATG16 PF08614.11 EXF73270.1 - 1 9.5 31.8 2.9 8.1 16.7 2.8 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) FPP PF05911.11 EXF73270.1 - 1.2 7.2 23.2 0.47 8.6 3.8 2.2 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil FUSC PF04632.12 EXF73270.1 - 1.2 7.6 16.6 0.11 11.0 11.4 1.6 1 1 0 1 1 1 0 Fusaric acid resistance protein family DUF1664 PF07889.12 EXF73270.1 - 1.4 9.0 13.8 12 6.0 0.4 2.8 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) DUF4665 PF15679.5 EXF73270.1 - 1.7 9.3 13.2 1.3 9.7 3.3 2.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4665) KASH_CCD PF14662.6 EXF73270.1 - 3 7.6 31.9 5.6 6.8 16.6 2.8 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH APG6_N PF17675.1 EXF73270.1 - 5.3 7.6 32.3 1.8 9.1 23.2 2.9 1 1 1 2 2 2 0 Apg6 coiled-coil region BRE1 PF08647.11 EXF73270.1 - 7.8 6.7 25.6 0.75 9.9 4.9 3.3 1 1 2 3 3 3 0 BRE1 E3 ubiquitin ligase CENP-F_leu_zip PF10473.9 EXF73270.1 - 9.9 6.2 30.7 2 8.4 5.5 2.7 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 2-Hacid_dh_C PF02826.19 EXF73272.1 - 1.2e-53 181.1 0.0 1.9e-53 180.4 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EXF73272.1 - 8.2e-33 112.9 0.0 5.9e-32 110.1 0.0 2.0 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 EXF73272.1 - 5.5e-06 26.6 0.4 1.6e-05 25.2 0.4 1.8 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase AdoHcyase_NAD PF00670.21 EXF73272.1 - 0.00065 19.8 0.1 0.0014 18.7 0.1 1.5 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain IlvN PF07991.12 EXF73272.1 - 0.0029 17.2 0.3 0.023 14.3 0.1 2.1 2 0 0 2 2 2 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain XdhC_C PF13478.6 EXF73272.1 - 0.02 15.4 0.0 0.08 13.4 0.0 1.9 2 0 0 2 2 2 0 XdhC Rossmann domain 3HCDH_N PF02737.18 EXF73272.1 - 0.029 14.3 2.4 1.2 9.0 0.6 2.6 1 1 1 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ACT PF01842.25 EXF73272.1 - 0.063 13.1 0.3 0.18 11.6 0.1 2.0 2 0 0 2 2 2 0 ACT domain NAP PF00956.18 EXF73273.1 - 2.8e-101 338.3 10.5 2.8e-101 338.3 10.5 1.5 2 0 0 2 2 2 1 Nucleosome assembly protein (NAP) Striatin PF08232.12 EXF73273.1 - 0.015 15.9 2.1 0.015 15.9 2.1 2.7 2 1 0 2 2 2 0 Striatin family RNA_pol_3_Rpc31 PF11705.8 EXF73273.1 - 8.3 6.6 33.4 1.5 9.0 19.4 2.4 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 P5-ATPase PF12409.8 EXF73274.1 - 4.1e-39 133.5 0.8 7.4e-39 132.7 0.0 1.9 2 0 0 2 2 2 1 P5-type ATPase cation transporter E1-E2_ATPase PF00122.20 EXF73274.1 - 6.1e-29 100.8 0.0 1.8e-28 99.3 0.0 1.8 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 EXF73274.1 - 8.5e-14 52.3 0.8 2.3e-05 24.8 0.0 3.2 3 0 0 3 3 3 3 haloacid dehalogenase-like hydrolase Cation_ATPase_C PF00689.21 EXF73274.1 - 3.9e-06 26.7 3.9 3.9e-06 26.7 3.9 1.8 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.6 EXF73274.1 - 0.016 15.3 0.0 0.033 14.3 0.0 1.5 1 0 0 1 1 1 0 Cation transport ATPase (P-type) UQ_con PF00179.26 EXF73275.1 - 2.5e-18 66.1 0.0 4e-18 65.4 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EXF73275.1 - 0.088 13.1 0.0 0.2 11.9 0.0 1.6 1 0 0 1 1 1 0 RWD domain B-block_TFIIIC PF04182.12 EXF73276.1 - 1.5e-12 47.5 0.0 3.2e-12 46.4 0.0 1.6 1 0 0 1 1 1 1 B-block binding subunit of TFIIIC zf-TFIIB PF13453.6 EXF73276.1 - 0.12 11.7 0.1 0.27 10.6 0.1 1.5 1 0 0 1 1 1 0 Transcription factor zinc-finger Cyanate_lyase PF02560.14 EXF73279.1 - 9.1e-32 108.7 0.0 1.7e-31 107.9 0.0 1.4 1 0 0 1 1 1 1 Cyanate lyase C-terminal domain HTH_31 PF13560.6 EXF73279.1 - 6.6e-05 23.2 0.0 9.3e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_3 PF01381.22 EXF73279.1 - 0.0014 18.6 0.1 0.0022 18.0 0.1 1.3 1 0 0 1 1 1 1 Helix-turn-helix Sigma70_r4_2 PF08281.12 EXF73279.1 - 0.0024 17.5 0.0 0.0053 16.4 0.0 1.5 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_38 PF13936.6 EXF73279.1 - 0.029 14.1 0.0 0.056 13.2 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain DUF3786 PF12654.7 EXF73279.1 - 0.033 13.8 0.0 0.058 13.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3786) Sigma70_r4 PF04545.16 EXF73279.1 - 0.059 12.9 0.0 0.11 12.0 0.0 1.5 1 0 0 1 1 1 0 Sigma-70, region 4 Ebp2 PF05890.12 EXF73280.1 - 9.5e-90 300.8 16.2 9.5e-90 300.8 16.2 2.9 2 1 0 2 2 2 1 Eukaryotic rRNA processing protein EBP2 CPDase PF07823.11 EXF73280.1 - 0.023 14.4 0.0 0.044 13.5 0.0 1.5 1 0 0 1 1 1 0 Cyclic phosphodiesterase-like protein zf-MYND PF01753.18 EXF73281.1 - 1.1e-07 31.8 18.9 1.1e-07 31.8 18.9 2.0 2 0 0 2 2 2 1 MYND finger PIG-Y PF15159.6 EXF73283.1 - 4.4e-21 75.6 6.7 7.1e-21 74.9 6.7 1.3 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y Sdh_cyt PF01127.22 EXF73283.1 - 0.06 13.4 0.7 0.11 12.6 0.7 1.3 1 0 0 1 1 1 0 Succinate dehydrogenase/Fumarate reductase transmembrane subunit TFIIA PF03153.13 EXF73283.1 - 0.14 12.1 14.5 0.2 11.6 14.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Cation_efflux PF01545.21 EXF73284.1 - 1.2e-12 47.9 12.1 1.7e-12 47.5 12.1 1.1 1 0 0 1 1 1 1 Cation efflux family Oleosin PF01277.17 EXF73284.1 - 0.3 10.9 3.8 0.68 9.7 0.9 2.7 3 0 0 3 3 3 0 Oleosin Dynamin_N PF00350.23 EXF73285.1 - 1.5e-43 148.8 0.0 2.8e-43 147.9 0.0 1.5 1 0 0 1 1 1 1 Dynamin family Dynamin_M PF01031.20 EXF73285.1 - 4.3e-12 45.9 0.1 1.7e-09 37.4 0.0 2.3 2 0 0 2 2 2 2 Dynamin central region MMR_HSR1 PF01926.23 EXF73285.1 - 9.3e-06 25.7 0.0 0.00013 22.0 0.0 2.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase DUF4872 PF16169.5 EXF73285.1 - 0.0051 16.6 1.7 0.017 14.9 0.7 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4872) AAA_16 PF13191.6 EXF73285.1 - 0.023 15.1 3.6 0.069 13.5 0.0 2.9 3 1 0 3 3 3 0 AAA ATPase domain AAA_21 PF13304.6 EXF73285.1 - 0.045 13.5 0.0 0.086 12.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system Roc PF08477.13 EXF73285.1 - 0.064 13.5 0.3 0.45 10.7 0.0 2.3 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_28 PF13521.6 EXF73285.1 - 0.079 13.2 0.0 0.22 11.8 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_15 PF13175.6 EXF73285.1 - 0.095 12.4 0.1 0.24 11.1 0.1 1.6 1 0 0 1 1 1 0 AAA ATPase domain GATase_4 PF13230.6 EXF73286.1 - 3.8e-16 58.8 0.0 5.2e-14 51.8 0.0 2.2 1 1 0 1 1 1 1 Glutamine amidotransferases class-II GATase_6 PF13522.6 EXF73286.1 - 4.2e-08 33.5 0.0 9.8e-08 32.3 0.0 1.7 1 0 0 1 1 1 1 Glutamine amidotransferase domain PQ-loop PF04193.14 EXF73288.1 - 1.1e-28 98.7 10.0 1e-16 60.4 0.5 3.0 3 0 0 3 3 3 2 PQ loop repeat Mito_carr PF00153.27 EXF73289.1 - 1.7e-72 239.4 0.3 3.5e-25 87.8 0.0 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_1 PF00036.32 EXF73289.1 - 1.4e-17 61.8 7.3 1e-07 31.0 0.5 5.2 5 0 0 5 5 5 3 EF hand EF-hand_6 PF13405.6 EXF73289.1 - 1.5e-17 61.9 4.4 9.6e-08 31.4 0.4 5.4 6 0 0 6 6 6 3 EF-hand domain EF-hand_7 PF13499.6 EXF73289.1 - 1.9e-16 60.2 6.2 1.5e-09 38.2 0.6 3.2 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 EXF73289.1 - 1.1e-12 46.8 6.0 3.6e-06 26.2 1.3 4.4 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 EXF73289.1 - 2.3e-08 33.7 2.8 0.36 10.7 0.0 5.4 5 0 0 5 5 5 4 EF-hand domain pair EF-hand_9 PF14658.6 EXF73289.1 - 0.028 14.7 0.0 17 5.8 0.0 3.5 4 0 0 4 4 4 0 EF-hand domain PepX_C PF08530.10 EXF73290.1 - 3.4e-46 158.0 0.2 5.1e-46 157.4 0.2 1.2 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain Peptidase_S15 PF02129.18 EXF73290.1 - 1.4e-39 136.3 0.1 2.1e-39 135.8 0.1 1.1 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Hydrolase_4 PF12146.8 EXF73290.1 - 0.011 15.0 0.0 0.018 14.3 0.0 1.2 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Aldedh PF00171.22 EXF73292.1 - 1.2e-11 43.8 0.9 2.7e-06 26.2 0.2 2.1 2 0 0 2 2 2 2 Aldehyde dehydrogenase family LigB PF02900.18 EXF73293.1 - 1.9e-11 43.6 0.1 6e-11 41.9 0.1 1.7 1 1 0 1 1 1 1 Catalytic LigB subunit of aromatic ring-opening dioxygenase Med5 PF08689.10 EXF73294.1 - 2.4e-97 327.0 0.0 2.1e-96 323.9 0.0 2.5 1 1 0 1 1 1 1 Mediator complex subunit Med5 SSF PF00474.17 EXF73294.1 - 0.04 12.8 0.2 0.072 11.9 0.2 1.3 1 0 0 1 1 1 0 Sodium:solute symporter family Arm PF00514.23 EXF73295.1 - 9e-96 311.4 16.1 3.9e-13 48.9 0.0 8.4 8 0 0 8 8 8 8 Armadillo/beta-catenin-like repeat IBB PF01749.20 EXF73295.1 - 2.8e-27 95.0 1.3 2.8e-27 95.0 1.3 1.8 2 0 0 2 2 1 1 Importin beta binding domain Arm_3 PF16186.5 EXF73295.1 - 1.3e-23 82.3 4.9 2.1e-23 81.6 4.2 1.7 2 0 0 2 2 2 1 Atypical Arm repeat HEAT_EZ PF13513.6 EXF73295.1 - 9.7e-23 80.3 8.6 7.4e-09 35.9 0.1 6.4 5 1 1 6 6 6 4 HEAT-like repeat HEAT_2 PF13646.6 EXF73295.1 - 5.3e-19 68.4 0.1 1.5e-08 34.9 0.0 5.3 1 1 5 6 6 6 4 HEAT repeats HEAT PF02985.22 EXF73295.1 - 1.1e-18 65.7 2.6 1.7e-05 24.7 0.0 7.1 8 0 0 8 8 8 4 HEAT repeat Arm_2 PF04826.13 EXF73295.1 - 8.5e-08 32.0 0.0 0.034 13.6 0.0 4.0 2 1 2 4 4 4 3 Armadillo-like Adaptin_N PF01602.20 EXF73295.1 - 3.7e-05 22.5 0.0 0.0022 16.6 0.0 2.6 1 1 1 2 2 2 1 Adaptin N terminal region V-ATPase_H_C PF11698.8 EXF73295.1 - 9.9e-05 22.4 0.0 2 8.5 0.0 4.3 3 2 2 5 5 5 2 V-ATPase subunit H HEAT_PBS PF03130.16 EXF73295.1 - 0.00076 19.9 0.2 1.7 9.6 0.0 4.4 4 0 0 4 4 4 1 PBS lyase HEAT-like repeat Cnd1 PF12717.7 EXF73295.1 - 0.0013 18.8 0.0 2.1 8.4 0.0 2.8 2 1 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 NopRA1 PF16201.5 EXF73295.1 - 0.028 14.0 0.0 7.4 6.1 0.0 3.8 2 2 2 4 4 4 0 Nucleolar pre-ribosomal-associated protein 1 RICTOR_V PF14668.6 EXF73295.1 - 0.037 14.2 4.9 3.4 8.0 0.1 4.7 3 2 3 6 6 6 0 Rapamycin-insensitive companion of mTOR, domain 5 Glycos_trans_3N PF02885.17 EXF73295.1 - 0.11 12.3 0.0 7.2 6.5 0.0 3.1 3 0 0 3 3 3 0 Glycosyl transferase family, helical bundle domain POT1PC PF16686.5 EXF73296.1 - 3.3e-48 163.5 2.8 3.9e-48 163.2 0.5 2.3 3 0 0 3 3 3 1 ssDNA-binding domain of telomere protection protein POT1 PF02765.17 EXF73296.1 - 1.7e-16 60.4 0.0 2.2e-15 56.7 0.0 2.3 2 0 0 2 2 2 1 Telomeric single stranded DNA binding POT1/CDC13 REPA_OB_2 PF16900.5 EXF73296.1 - 0.0053 16.7 0.0 0.024 14.5 0.0 2.1 2 0 0 2 2 2 1 Replication protein A OB domain STAG PF08514.11 EXF73297.1 - 1.8e-32 111.6 0.1 1.8e-32 111.6 0.1 3.2 4 0 0 4 4 4 1 STAG domain HEAT_2 PF13646.6 EXF73297.1 - 0.00026 21.3 0.0 2.3 8.7 0.0 3.8 2 1 1 3 3 3 2 HEAT repeats T3SS_basalb_I PF17001.5 EXF73297.1 - 0.032 14.8 0.2 0.16 12.6 0.0 2.3 2 0 0 2 2 2 0 Type III secretion basal body protein I, YscI, HrpB, PscI Cnd1 PF12717.7 EXF73297.1 - 0.054 13.5 0.7 1.6 8.8 0.1 3.1 2 1 1 3 3 3 0 non-SMC mitotic condensation complex subunit 1 UreD PF01774.17 EXF73298.1 - 5.5e-76 255.2 0.0 6.6e-76 254.9 0.0 1.1 1 0 0 1 1 1 1 UreD urease accessory protein RNA_pol_Rpc4 PF05132.14 EXF73299.1 - 8.9e-32 110.6 0.0 8.9e-32 110.6 0.0 3.4 4 1 0 4 4 4 1 RNA polymerase III RPC4 Med3 PF11593.8 EXF73299.1 - 1.2 8.2 12.7 2.2 7.4 12.7 1.3 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal FAD_binding_3 PF01494.19 EXF73300.1 - 3.9e-21 75.7 0.1 2.5e-11 43.4 0.0 2.1 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.24 EXF73300.1 - 3.3e-10 40.1 0.5 0.00082 19.0 0.3 2.4 1 1 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EXF73300.1 - 2.3e-05 23.8 0.1 0.00014 21.2 0.1 2.1 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 EXF73300.1 - 3.5e-05 23.3 0.4 0.0025 17.2 0.0 2.6 3 0 0 3 3 3 1 Flavin containing amine oxidoreductase Lycopene_cycl PF05834.12 EXF73300.1 - 4.9e-05 22.5 0.6 0.027 13.6 0.2 2.0 2 0 0 2 2 2 2 Lycopene cyclase protein HI0933_like PF03486.14 EXF73300.1 - 5e-05 22.2 0.5 0.0093 14.7 0.2 2.5 2 1 1 3 3 3 2 HI0933-like protein FAD_binding_2 PF00890.24 EXF73300.1 - 7.7e-05 21.9 0.6 0.0024 17.0 0.6 2.2 1 1 1 2 2 2 1 FAD binding domain NAD_binding_8 PF13450.6 EXF73300.1 - 0.0021 18.3 0.1 0.0057 16.8 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 EXF73300.1 - 0.047 14.2 0.0 4.6 7.9 0.1 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EXF73300.1 - 0.24 10.6 0.1 0.37 10.0 0.1 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Abhydrolase_6 PF12697.7 EXF73302.1 - 5.6e-07 30.4 0.9 9.2e-07 29.7 0.9 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.13 EXF73302.1 - 4.6e-06 26.6 0.5 3.8e-05 23.7 0.5 2.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EXF73302.1 - 0.13 11.7 0.0 2.1 7.8 0.0 2.1 2 0 0 2 2 2 0 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 EXF73302.1 - 0.16 11.2 0.0 3.1 7.0 0.0 2.1 2 0 0 2 2 2 0 Serine aminopeptidase, S33 MFS_1 PF07690.16 EXF73303.1 - 4.1e-31 108.2 56.6 2.8e-30 105.4 39.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2070 PF09843.9 EXF73303.1 - 1.4 7.2 10.3 2 6.6 10.3 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) GTP_EFTU PF00009.27 EXF73304.1 - 4.2e-49 166.7 0.0 7e-49 166.0 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain LepA_C PF06421.12 EXF73304.1 - 2.9e-42 143.2 3.3 6e-42 142.1 3.3 1.6 1 0 0 1 1 1 1 GTP-binding protein LepA C-terminus EFG_C PF00679.24 EXF73304.1 - 2.5e-18 65.9 0.0 5.1e-18 64.9 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus MIT PF04212.18 EXF73304.1 - 1.7e-14 53.6 2.6 4e-14 52.4 2.6 1.7 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain MMR_HSR1 PF01926.23 EXF73304.1 - 9.5e-05 22.5 0.0 0.00022 21.3 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase EFG_II PF14492.6 EXF73304.1 - 0.00031 20.8 0.0 0.00083 19.4 0.0 1.8 1 0 0 1 1 1 1 Elongation Factor G, domain II Ras PF00071.22 EXF73304.1 - 0.00031 20.4 0.0 0.00065 19.3 0.0 1.5 1 0 0 1 1 1 1 Ras family GTP_EFTU_D2 PF03144.25 EXF73304.1 - 0.00036 20.9 0.1 0.00083 19.7 0.1 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RF3_C PF16658.5 EXF73304.1 - 0.018 14.8 0.0 0.052 13.4 0.0 1.7 1 0 0 1 1 1 0 Class II release factor RF3, C-terminal domain SRPRB PF09439.10 EXF73304.1 - 0.12 11.8 0.0 0.32 10.4 0.0 1.7 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit His_Phos_1 PF00300.22 EXF73305.1 - 1e-14 54.7 0.0 1.5e-14 54.2 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) CTNNBL PF08216.11 EXF73306.1 - 3.8e-40 136.3 0.0 2.5e-39 133.6 0.0 2.4 2 0 0 2 2 2 1 Catenin-beta-like, Arm-motif containing nuclear Arm PF00514.23 EXF73306.1 - 0.023 14.8 0.0 1.7 8.8 0.0 3.1 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat V-ATPase_G PF03179.15 EXF73307.1 - 2.9e-32 111.3 16.6 3.5e-32 111.1 16.6 1.1 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit DUF3552 PF12072.8 EXF73307.1 - 0.0026 17.2 10.2 0.0026 17.2 10.2 2.0 1 1 1 2 2 2 1 Domain of unknown function (DUF3552) YusW PF14039.6 EXF73307.1 - 0.0071 16.8 3.2 0.012 16.1 3.2 1.4 1 0 0 1 1 1 1 YusW-like protein RRF PF01765.19 EXF73307.1 - 0.036 14.0 10.1 0.046 13.7 10.1 1.3 1 0 0 1 1 1 0 Ribosome recycling factor SAPS PF04499.15 EXF73307.1 - 0.095 11.5 5.8 0.1 11.3 5.8 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein V-ATPase_G_2 PF16999.5 EXF73307.1 - 0.21 12.0 15.4 0.33 11.4 15.4 1.4 1 1 0 1 1 1 0 Vacuolar (H+)-ATPase G subunit ATP11 PF06644.11 EXF73307.1 - 0.43 10.3 9.0 0.54 10.0 9.0 1.1 1 0 0 1 1 1 0 ATP11 protein ATP-synt_B PF00430.18 EXF73307.1 - 0.54 10.3 20.4 0.077 13.1 10.4 2.1 1 1 1 2 2 2 0 ATP synthase B/B' CF(0) DUF2203 PF09969.9 EXF73307.1 - 1 10.1 8.0 1.5 9.6 7.9 1.3 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) DUF2229 PF09989.9 EXF73307.1 - 9.2 5.8 8.1 12 5.4 8.1 1.3 1 1 0 1 1 1 0 CoA enzyme activase uncharacterised domain (DUF2229) RNA_pol_Rpb2_6 PF00562.28 EXF73308.1 - 3.5e-125 418.1 0.1 5.5e-125 417.5 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 EXF73308.1 - 4.5e-56 189.6 0.0 1.4e-55 187.9 0.0 1.8 1 1 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.14 EXF73308.1 - 2.1e-47 161.2 0.0 4.3e-47 160.2 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.20 EXF73308.1 - 1.2e-33 115.4 0.1 2.7e-33 114.2 0.1 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_3 PF04565.16 EXF73308.1 - 2e-25 88.7 0.1 4.9e-25 87.5 0.1 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.17 EXF73308.1 - 4.5e-24 84.8 1.1 1.4e-23 83.2 1.1 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 RNA_pol_Rpb2_4 PF04566.13 EXF73308.1 - 2.7e-20 72.4 3.1 3.1e-20 72.2 1.4 2.1 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_45 PF10385.9 EXF73308.1 - 0.2 12.0 0.3 8.3 6.8 0.1 3.0 2 0 0 2 2 2 0 RNA polymerase beta subunit external 1 domain IDO PF01231.18 EXF73309.1 - 1.1e-167 558.2 0.0 1.3e-167 558.0 0.0 1.0 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase UEV PF05743.13 EXF73310.1 - 8.4e-37 125.7 0.0 8.4e-37 125.7 0.0 1.7 2 0 0 2 2 2 1 UEV domain Vps23_core PF09454.10 EXF73310.1 - 1.5e-21 76.1 0.0 2.6e-21 75.3 0.0 1.4 1 0 0 1 1 1 1 Vps23 core domain UQ_con PF00179.26 EXF73310.1 - 0.021 14.5 0.1 0.038 13.6 0.1 1.4 1 0 0 1 1 1 0 Ubiquitin-conjugating enzyme HCR PF07111.12 EXF73310.1 - 0.023 12.8 1.3 0.041 12.0 1.3 1.3 1 0 0 1 1 1 0 Alpha helical coiled-coil rod protein (HCR) STE2 PF02116.15 EXF73312.1 - 1.1e-10 41.3 0.6 1.2e-10 41.2 0.6 1.0 1 0 0 1 1 1 1 Fungal pheromone mating factor STE2 GPCR DUF1996 PF09362.10 EXF73313.1 - 1.1e-88 297.1 0.1 1.7e-88 296.6 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1996) WSC PF01822.19 EXF73313.1 - 1.2e-20 73.4 9.4 1.2e-20 73.4 9.4 2.5 2 0 0 2 2 2 1 WSC domain Tom6 PF17112.5 EXF73314.1 - 0.1 12.1 0.0 0.12 11.9 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial import receptor subunit Tom6, fungal TFB6 PF17110.5 EXF73315.1 - 5.9e-69 231.2 0.1 7.2e-69 230.9 0.1 1.1 1 0 0 1 1 1 1 Subunit 11 of the general transcription factor TFIIH Pes-10 PF07149.11 EXF73315.1 - 1.8 7.5 4.9 2.5 7.1 4.9 1.1 1 0 0 1 1 1 0 Pes-10 DNA_pol_phi PF04931.13 EXF73315.1 - 4.5 5.2 7.1 5.8 4.9 7.1 1.1 1 0 0 1 1 1 0 DNA polymerase phi Glyco_hydro_16 PF00722.21 EXF73316.1 - 1.1e-16 60.9 0.3 3e-16 59.4 0.3 1.7 1 1 0 1 1 1 1 Glycosyl hydrolases family 16 SKN1 PF03935.15 EXF73316.1 - 6.9e-06 24.7 1.9 0.033 12.6 0.8 2.1 2 0 0 2 2 2 2 Beta-glucan synthesis-associated protein (SKN1) DUF2401 PF10287.9 EXF73316.1 - 0.00017 21.2 0.0 0.00031 20.4 0.0 1.4 1 0 0 1 1 1 1 Putative TOS1-like glycosyl hydrolase (DUF2401) TRAPP PF04051.16 EXF73318.1 - 1.1e-35 122.4 0.1 1.4e-35 122.2 0.1 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component PNGaseA PF12222.8 EXF73318.1 - 0.043 12.7 0.0 0.047 12.5 0.0 1.1 1 0 0 1 1 1 0 Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A DUF4250 PF14056.6 EXF73318.1 - 0.083 12.9 0.1 0.17 11.9 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4250) WD40 PF00400.32 EXF73319.1 - 3.6e-36 122.6 6.0 2.7e-07 31.2 0.0 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EXF73319.1 - 2.3e-13 50.2 0.1 0.0003 21.0 0.0 4.4 2 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EXF73319.1 - 0.0027 17.1 0.0 5.6 6.2 0.0 3.0 2 1 0 3 3 3 2 WD40-like domain Nucleoporin_N PF08801.11 EXF73319.1 - 0.0031 16.3 1.0 2.9 6.5 0.1 3.2 1 1 2 4 4 4 2 Nup133 N terminal like Ge1_WD40 PF16529.5 EXF73319.1 - 0.052 12.5 0.0 3.7 6.4 0.0 3.0 2 2 2 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 EXF73319.1 - 0.058 12.0 0.4 15 4.1 0.0 3.1 2 1 1 3 3 3 0 Nucleoporin Nup120/160 DUF3043 PF11241.8 EXF73320.1 - 0.013 15.5 0.1 0.024 14.7 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3043) Hepatitis_core PF00906.20 EXF73320.1 - 1 8.8 6.2 2 7.9 6.2 1.4 1 0 0 1 1 1 0 Hepatitis core antigen DUF726 PF05277.12 EXF73321.1 - 9.1e-127 422.7 0.4 1.3e-126 422.2 0.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF726) Fcf1 PF04900.12 EXF73322.1 - 3.2e-30 104.4 0.2 5.1e-30 103.8 0.2 1.3 1 0 0 1 1 1 1 Fcf1 CDC45 PF02724.14 EXF73322.1 - 0.45 8.7 9.1 0.59 8.4 9.1 1.2 1 0 0 1 1 1 0 CDC45-like protein PP2C PF00481.21 EXF73323.1 - 0.00011 21.9 0.0 0.014 15.1 0.0 2.1 2 0 0 2 2 2 2 Protein phosphatase 2C SpoIIE PF07228.12 EXF73323.1 - 0.0055 16.7 0.0 0.016 15.1 0.0 1.9 1 1 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) APOC4 PF15119.6 EXF73323.1 - 0.16 12.3 0.3 0.49 10.7 0.1 1.9 2 0 0 2 2 2 0 Apolipoprotein C4 PH PF00169.29 EXF73324.1 - 2.3e-07 31.2 0.1 4.8e-06 27.0 0.0 2.5 2 0 0 2 2 2 1 PH domain PH_9 PF15410.6 EXF73324.1 - 0.008 16.5 0.6 0.017 15.5 0.0 1.9 2 0 0 2 2 2 1 Pleckstrin homology domain DUF4055 PF13264.6 EXF73324.1 - 0.61 10.2 11.1 1.4 9.1 11.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4055) Pkinase PF00069.25 EXF73325.1 - 5.9e-61 206.1 0.0 1.7e-60 204.6 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF73325.1 - 1.5e-27 96.5 0.0 3e-27 95.6 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.26 EXF73325.1 - 1.3e-10 41.5 0.0 1.7e-08 34.7 0.0 2.7 2 0 0 2 2 2 1 FHA domain Yop-YscD_cpl PF16697.5 EXF73325.1 - 0.001 19.3 0.0 0.0037 17.5 0.0 1.9 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain Kinase-like PF14531.6 EXF73325.1 - 0.046 13.0 0.0 0.11 11.8 0.0 1.5 1 1 0 1 1 1 0 Kinase-like Kdo PF06293.14 EXF73325.1 - 0.11 11.8 0.1 0.2 11.0 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EXF73325.1 - 0.14 10.9 0.0 0.31 9.7 0.0 1.5 1 0 0 1 1 1 0 Fungal protein kinase FTA2 PF13095.6 EXF73325.1 - 0.17 11.5 0.1 1.4 8.4 0.1 2.4 2 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 zf-C2H2 PF00096.26 EXF73326.1 - 1.5e-09 37.7 11.5 3e-05 24.2 4.5 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EXF73326.1 - 7e-09 35.7 13.8 6.5e-05 23.2 0.5 3.6 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 EXF73326.1 - 1.5e-06 28.5 11.1 0.0017 19.0 3.2 2.9 2 0 0 2 2 2 2 C2H2-type zinc finger zf-met PF12874.7 EXF73326.1 - 9.3e-06 25.9 1.3 2.4e-05 24.5 1.3 1.7 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 EXF73326.1 - 0.00016 21.6 2.4 0.00016 21.6 2.4 2.5 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EXF73326.1 - 0.001 19.3 1.8 0.001 19.3 1.8 2.3 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 EXF73326.1 - 0.043 14.2 0.8 0.043 14.2 0.8 2.1 2 1 0 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-C2HC_2 PF13913.6 EXF73326.1 - 0.16 11.9 4.2 3.9 7.5 0.4 2.5 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf-C2H2_11 PF16622.5 EXF73326.1 - 1.1 9.1 8.3 9.4 6.1 1.2 2.8 2 0 0 2 2 2 0 zinc-finger C2H2-type RAP1 PF07218.11 EXF73326.1 - 7.5 4.7 5.0 1.4 7.1 1.6 1.4 2 0 0 2 2 2 0 Rhoptry-associated protein 1 (RAP-1) Rax2 PF12768.7 EXF73327.1 - 1.3e-73 247.0 0.2 1.5e-72 243.5 0.0 2.9 3 0 0 3 3 3 1 Cortical protein marker for cell polarity Syndecan PF01034.20 EXF73327.1 - 0.22 11.5 0.9 0.47 10.4 0.9 1.5 1 0 0 1 1 1 0 Syndecan domain P34-Arc PF04045.14 EXF73328.1 - 2.3e-107 358.1 0.1 3.2e-107 357.7 0.1 1.2 1 0 0 1 1 1 1 Arp2/3 complex, 34 kD subunit p34-Arc DUF4178 PF13785.6 EXF73328.1 - 0.11 12.6 0.0 0.26 11.4 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4178) WD40 PF00400.32 EXF73329.1 - 5.8e-48 159.9 30.7 8.6e-06 26.4 0.4 11.8 13 0 0 13 13 13 9 WD domain, G-beta repeat Utp12 PF04003.12 EXF73329.1 - 7.1e-19 68.1 0.0 1.4e-18 67.2 0.0 1.4 1 0 0 1 1 1 1 Dip2/Utp12 Family ANAPC4_WD40 PF12894.7 EXF73329.1 - 5.5e-15 55.4 6.2 0.0084 16.4 0.1 8.8 5 3 5 10 10 10 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EXF73329.1 - 4.1e-05 23.1 0.0 3.6 6.8 0.0 3.4 3 0 0 3 3 3 3 WD40-like domain Nucleoporin_N PF08801.11 EXF73329.1 - 0.0018 17.1 0.3 0.85 8.3 0.1 4.2 2 2 2 5 5 5 1 Nup133 N terminal like Nup160 PF11715.8 EXF73329.1 - 0.0022 16.7 5.3 0.26 9.9 0.1 5.0 6 1 0 6 6 6 1 Nucleoporin Nup120/160 eIF2A PF08662.11 EXF73329.1 - 0.0031 17.4 0.2 0.35 10.7 0.0 4.2 4 1 0 4 4 4 1 Eukaryotic translation initiation factor eIF2A Hira PF07569.11 EXF73329.1 - 0.097 12.4 0.1 0.64 9.7 0.0 2.5 2 0 0 2 2 2 0 TUP1-like enhancer of split Alg6_Alg8 PF03155.15 EXF73330.1 - 2.2e-128 429.3 27.6 1.4e-80 271.7 12.7 2.1 2 0 0 2 2 2 2 ALG6, ALG8 glycosyltransferase family BRO1 PF03097.18 EXF73331.1 - 2.7e-12 46.2 0.0 3.8e-12 45.7 0.0 1.2 1 0 0 1 1 1 1 BRO1-like domain Aldedh PF00171.22 EXF73332.1 - 3.2e-125 418.2 0.0 2.7e-124 415.2 0.0 1.9 1 1 0 1 1 1 1 Aldehyde dehydrogenase family CAP_N PF01213.19 EXF73332.1 - 1.6 8.2 6.9 2.6 7.4 6.9 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal COPIIcoated_ERV PF07970.12 EXF73333.1 - 2.7e-90 302.1 0.1 2.2e-89 299.1 0.1 2.0 2 0 0 2 2 2 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 EXF73333.1 - 3.2e-30 104.3 0.1 1.5e-29 102.2 0.0 2.0 2 0 0 2 2 2 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) CSTF2_hinge PF14327.6 EXF73334.1 - 1.2e-33 115.4 2.5 2.7e-33 114.3 2.5 1.6 1 0 0 1 1 1 1 Hinge domain of cleavage stimulation factor subunit 2 RRM_1 PF00076.22 EXF73334.1 - 3e-22 78.2 0.0 5.1e-22 77.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CSTF_C PF14304.6 EXF73334.1 - 8.4e-11 41.3 1.2 8.4e-11 41.3 1.2 3.2 4 0 0 4 4 4 1 Transcription termination and cleavage factor C-terminal Spo7_2_N PF15407.6 EXF73334.1 - 0.055 13.1 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 Sporulation protein family 7 RRM_7 PF16367.5 EXF73334.1 - 0.064 13.4 0.0 0.11 12.6 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif RRM_occluded PF16842.5 EXF73334.1 - 0.15 12.0 0.0 0.36 10.7 0.0 1.6 1 1 0 1 1 1 0 Occluded RNA-recognition motif CFEM PF05730.11 EXF73335.1 - 1.2e-15 57.3 14.2 2e-15 56.6 14.2 1.3 1 0 0 1 1 1 1 CFEM domain adh_short PF00106.25 EXF73336.1 - 7.3e-42 143.0 0.0 1.1e-41 142.5 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF73336.1 - 9.7e-32 110.4 0.0 1.3e-31 109.9 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF73336.1 - 1.3e-09 38.3 0.0 2e-09 37.6 0.0 1.2 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 EXF73336.1 - 0.001 18.5 0.0 0.0014 18.1 0.0 1.1 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) NAD_binding_10 PF13460.6 EXF73336.1 - 0.0054 16.6 0.1 0.0085 16.0 0.1 1.5 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EXF73336.1 - 0.011 15.2 0.0 0.045 13.2 0.0 2.1 2 1 0 2 2 2 0 NAD dependent epimerase/dehydratase family Eno-Rase_NADH_b PF12242.8 EXF73336.1 - 0.016 14.9 0.4 0.037 13.8 0.0 1.7 2 0 0 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase UxaE PF16257.5 EXF73336.1 - 0.052 12.2 0.0 0.075 11.7 0.0 1.2 1 0 0 1 1 1 0 tagaturonate epimerase COesterase PF00135.28 EXF73337.1 - 1e-85 288.6 0.0 2.5e-78 264.2 0.0 2.0 1 1 1 2 2 2 2 Carboxylesterase family Abhydrolase_3 PF07859.13 EXF73337.1 - 0.00043 20.2 0.0 0.0036 17.2 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold DUF917 PF06032.12 EXF73338.1 - 4.8e-111 371.0 1.8 4.8e-111 371.0 1.8 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF917) Hydantoinase_A PF01968.18 EXF73338.1 - 5.5e-30 104.6 10.7 1.7e-24 86.6 0.9 3.5 2 1 1 3 3 3 2 Hydantoinase/oxoprolinase Hydant_A_N PF05378.13 EXF73338.1 - 2.6e-25 89.2 2.4 4.4e-24 85.1 0.2 3.0 3 0 0 3 3 3 1 Hydantoinase/oxoprolinase N-terminal region BcrAD_BadFG PF01869.20 EXF73338.1 - 0.0025 17.4 0.2 0.0025 17.4 0.2 2.3 3 0 0 3 3 3 1 BadF/BadG/BcrA/BcrD ATPase family DUF2151 PF10221.9 EXF73338.1 - 0.29 9.7 0.4 0.45 9.0 0.4 1.2 1 0 0 1 1 1 0 Cell cycle and development regulator StbA PF06406.11 EXF73338.1 - 0.44 9.7 2.5 1.5 8.0 0.0 2.7 3 0 0 3 3 3 0 StbA protein Fungal_trans PF04082.18 EXF73339.1 - 1.6e-37 129.0 0.0 2.3e-37 128.5 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF73339.1 - 1.2e-06 28.5 12.7 2e-06 27.8 12.7 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Amidohydro_3 PF07969.11 EXF73340.1 - 1.4e-55 189.7 2.2 1.7e-55 189.4 2.2 1.0 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_1 PF01979.20 EXF73340.1 - 0.00049 19.5 1.9 0.16 11.3 0.1 2.5 2 1 0 2 2 2 2 Amidohydrolase family Cellulase PF00150.18 EXF73341.1 - 7.7e-17 61.6 0.8 1.4e-16 60.8 0.8 1.4 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Peptidase_M14 PF00246.24 EXF73342.1 - 3.6e-83 279.7 0.2 4.7e-83 279.3 0.2 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase Propep_M14 PF02244.16 EXF73342.1 - 4.3e-05 23.8 0.0 0.00033 21.0 0.0 2.4 3 0 0 3 3 3 1 Carboxypeptidase activation peptide NmrA PF05368.13 EXF73343.1 - 1.4e-08 34.6 0.0 1.7e-08 34.3 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EXF73343.1 - 4.4e-07 30.0 0.0 6.5e-07 29.4 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding INCENP_ARK-bind PF03941.15 EXF73343.1 - 0.14 12.1 0.0 0.38 10.7 0.0 1.7 1 0 0 1 1 1 0 Inner centromere protein, ARK binding region Beta_helix PF13229.6 EXF73344.1 - 1.8e-10 40.9 10.6 1.8e-10 40.9 10.6 2.7 2 1 1 3 3 3 2 Right handed beta helix region Chondroitinas_B PF14592.6 EXF73344.1 - 5.3e-06 25.6 0.1 9.6e-06 24.7 0.1 1.3 1 0 0 1 1 1 1 Chondroitinase B DUF1565 PF07602.11 EXF73344.1 - 0.0037 16.6 0.8 0.016 14.6 0.0 2.2 2 1 0 2 2 2 1 Protein of unknown function (DUF1565) Orthoreo_P10 PF07204.11 EXF73345.1 - 0.0051 16.7 0.0 0.0077 16.2 0.0 1.2 1 0 0 1 1 1 1 Orthoreovirus membrane fusion protein p10 KxDL PF10241.9 EXF73345.1 - 0.019 15.2 1.3 0.037 14.3 1.3 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein Atg14 PF10186.9 EXF73345.1 - 0.18 10.8 9.0 0.22 10.6 9.0 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 YqjK PF13997.6 EXF73345.1 - 0.52 10.6 0.0 0.52 10.6 0.0 2.5 3 0 0 3 3 3 0 YqjK-like protein THOC7 PF05615.13 EXF73345.1 - 1.5 9.1 10.8 26 5.1 10.8 2.1 1 1 0 1 1 1 0 Tho complex subunit 7 DUF3450 PF11932.8 EXF73346.1 - 0.00016 21.1 6.8 0.00016 21.1 6.8 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF3450) DUF948 PF06103.11 EXF73346.1 - 0.0033 17.7 2.2 0.0033 17.7 2.2 2.9 2 1 1 3 3 3 1 Bacterial protein of unknown function (DUF948) DUF4795 PF16043.5 EXF73346.1 - 0.0038 16.9 18.7 0.007 16.0 18.7 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF4795) DUF5344 PF17279.2 EXF73346.1 - 0.005 17.4 4.8 0.005 17.4 4.8 3.5 2 2 1 3 3 3 1 Family of unknown function (DUF5344) LMBR1 PF04791.16 EXF73346.1 - 0.0068 15.4 3.9 0.0086 15.0 3.9 1.1 1 0 0 1 1 1 1 LMBR1-like membrane protein HemX PF04375.14 EXF73346.1 - 0.0088 15.4 4.8 0.0088 15.4 4.8 2.1 1 1 1 2 2 2 1 HemX, putative uroporphyrinogen-III C-methyltransferase SLATT_4 PF18186.1 EXF73346.1 - 0.033 13.8 6.1 0.052 13.2 6.1 1.3 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 4 DUF2959 PF11172.8 EXF73346.1 - 0.044 13.9 10.7 0.03 14.5 4.0 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF2959) FlaC_arch PF05377.11 EXF73346.1 - 0.073 13.5 6.8 0.21 12.0 3.4 2.8 3 1 0 3 3 2 0 Flagella accessory protein C (FlaC) NPV_P10 PF05531.12 EXF73346.1 - 0.076 13.5 6.7 0.041 14.3 3.8 2.2 2 1 0 2 2 1 0 Nucleopolyhedrovirus P10 protein Na_K-ATPase PF00287.18 EXF73346.1 - 0.11 11.7 0.3 0.14 11.3 0.3 1.2 1 0 0 1 1 1 0 Sodium / potassium ATPase beta chain TMF_TATA_bd PF12325.8 EXF73346.1 - 0.23 11.7 18.2 0.035 14.3 10.6 2.6 1 1 2 3 3 3 0 TATA element modulatory factor 1 TATA binding DUF3349 PF11829.8 EXF73346.1 - 0.29 11.9 1.6 0.82 10.5 1.6 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3349) MutS_III PF05192.18 EXF73346.1 - 0.58 10.4 7.1 0.2 11.8 2.8 2.0 2 0 0 2 2 2 0 MutS domain III FapA PF03961.13 EXF73346.1 - 0.91 8.1 12.1 0.42 9.2 9.8 1.5 1 1 1 2 2 2 0 Flagellar Assembly Protein A EDR1 PF14381.6 EXF73346.1 - 1.1 9.0 5.7 11 5.7 2.8 2.3 1 1 1 2 2 2 0 Ethylene-responsive protein kinase Le-CTR1 Spc7 PF08317.11 EXF73346.1 - 1.3 7.8 17.9 2.4 7.0 17.9 1.4 1 1 0 1 1 1 0 Spc7 kinetochore protein DUF1664 PF07889.12 EXF73346.1 - 1.8 8.7 10.8 2.4 8.2 5.6 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) DivIC PF04977.15 EXF73346.1 - 2.5 7.9 12.7 8.2 6.3 7.9 2.8 2 1 0 2 2 2 0 Septum formation initiator DUF4094 PF13334.6 EXF73346.1 - 3 8.3 7.6 2 8.9 0.4 3.3 3 1 0 3 3 3 0 Domain of unknown function (DUF4094) Fib_alpha PF08702.10 EXF73346.1 - 5 7.3 9.9 94 3.2 9.9 2.4 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DUF3837 PF12939.7 EXF73346.1 - 5.5 7.5 10.4 0.73 10.3 3.4 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF3837) ACCA PF03255.14 EXF73346.1 - 7.5 6.4 11.7 2.4 8.1 7.0 2.3 1 1 1 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit BLOC1_2 PF10046.9 EXF73346.1 - 9.7 6.6 15.3 0.92 9.9 6.5 2.9 1 1 2 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF21 PF01595.20 EXF73346.1 - 10 5.8 9.7 0.24 11.1 1.0 2.4 3 1 0 3 3 2 0 Cyclin M transmembrane N-terminal domain Mannosyl_trans3 PF11051.8 EXF73347.1 - 1.1e-44 152.9 0.0 2e-44 152.0 0.0 1.4 1 1 0 1 1 1 1 Mannosyltransferase putative Nucleotid_trans PF03407.16 EXF73347.1 - 0.069 13.1 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 Nucleotide-diphospho-sugar transferase Glyco_hydro_3 PF00933.21 EXF73348.1 - 4.6e-51 174.1 0.0 6.4e-51 173.6 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.22 EXF73348.1 - 1.4e-13 51.3 0.1 1.1e-11 45.1 0.0 2.2 1 1 1 2 2 2 2 Glycosyl hydrolase family 3 C-terminal domain Bac_luciferase PF00296.20 EXF73349.1 - 2.1e-54 185.1 0.3 3.2e-54 184.5 0.3 1.1 1 0 0 1 1 1 1 Luciferase-like monooxygenase MFS_1 PF07690.16 EXF73350.1 - 8.2e-32 110.5 35.0 1e-30 106.9 30.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Spectrin_like PF18373.1 EXF73350.1 - 0.15 12.1 0.2 1.3 9.1 0.2 2.2 2 0 0 2 2 2 0 Spectrin like domain FBPase PF00316.20 EXF73351.1 - 1.5e-22 80.0 0.4 3.5e-22 78.8 0.4 1.5 1 1 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain DUF924 PF06041.11 EXF73352.1 - 1.5e-52 178.3 0.4 1.8e-52 178.1 0.4 1.0 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF924) Complex1_LYR_2 PF13233.6 EXF73352.1 - 0.11 13.3 2.1 1.4 9.7 2.5 2.2 2 1 0 2 2 2 0 Complex1_LYR-like Ring_hydroxyl_A PF00848.19 EXF73353.1 - 4.5e-25 88.9 5.9 6e-22 78.7 5.9 2.3 1 1 0 1 1 1 1 Ring hydroxylating alpha subunit (catalytic domain) Rieske PF00355.26 EXF73353.1 - 3.5e-16 58.9 0.0 6.2e-16 58.1 0.0 1.4 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain p450 PF00067.22 EXF73354.1 - 1.7e-74 251.3 0.0 2e-74 251.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 TetR_C_8 PF14278.6 EXF73354.1 - 0.13 12.4 0.0 0.4 10.8 0.0 1.8 1 0 0 1 1 1 0 Transcriptional regulator C-terminal region CorA PF01544.18 EXF73355.1 - 0.00011 21.6 2.3 0.00021 20.7 2.3 1.6 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein EMP70 PF02990.16 EXF73355.1 - 0.0059 15.3 0.4 0.0078 14.9 0.4 1.1 1 0 0 1 1 1 1 Endomembrane protein 70 Ninjurin PF04923.12 EXF73355.1 - 0.0065 16.4 0.9 2.3 8.2 0.1 2.3 2 0 0 2 2 2 2 Ninjurin p450 PF00067.22 EXF73356.1 - 5.6e-69 233.1 0.0 8.2e-69 232.5 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 Cupin_2 PF07883.11 EXF73357.1 - 1.5e-13 50.2 0.2 3.2e-13 49.2 0.2 1.6 1 0 0 1 1 1 1 Cupin domain Cupin_1 PF00190.22 EXF73357.1 - 0.0097 15.5 0.0 0.014 15.0 0.0 1.2 1 0 0 1 1 1 1 Cupin Flavin_Reduct PF01613.18 EXF73358.1 - 8.7e-13 48.6 0.0 1.3e-12 48.0 0.0 1.1 1 0 0 1 1 1 1 Flavin reductase like domain Fungal_trans PF04082.18 EXF73359.1 - 9.1e-10 38.0 0.1 3.5e-09 36.1 0.0 1.9 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF73359.1 - 2.7e-08 33.8 10.8 2.7e-08 33.8 10.8 1.7 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Beta-lactamase PF00144.24 EXF73360.1 - 3.3e-35 121.9 0.0 4.5e-35 121.5 0.0 1.1 1 0 0 1 1 1 1 Beta-lactamase Fungal_trans PF04082.18 EXF73361.1 - 6.4e-14 51.6 0.0 1.4e-13 50.5 0.0 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF73361.1 - 9.4e-09 35.3 10.5 2.4e-08 34.0 10.5 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain NmrA PF05368.13 EXF73362.1 - 2e-27 96.3 0.1 3.4e-27 95.5 0.1 1.3 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EXF73362.1 - 2.7e-23 82.8 0.4 1.8e-22 80.2 0.0 2.6 4 0 0 4 4 4 1 NAD(P)H-binding Amidohydro_1 PF01979.20 EXF73362.1 - 9.1e-18 64.7 2.9 5.6e-10 39.1 0.0 2.8 3 0 0 3 3 3 2 Amidohydrolase family Amidohydro_3 PF07969.11 EXF73362.1 - 4.8e-15 56.0 0.4 2e-09 37.4 0.1 2.5 2 0 0 2 2 2 2 Amidohydrolase family Epimerase PF01370.21 EXF73362.1 - 0.00021 20.8 0.0 0.00046 19.7 0.0 1.6 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NYN_YacP PF05991.11 EXF73362.1 - 0.0029 17.6 0.1 0.0082 16.1 0.1 1.7 1 0 0 1 1 1 1 YacP-like NYN domain 3Beta_HSD PF01073.19 EXF73362.1 - 0.031 13.3 0.1 0.091 11.8 0.0 1.7 2 0 0 2 2 2 0 3-beta hydroxysteroid dehydrogenase/isomerase family FAA_hydrolase PF01557.18 EXF73363.1 - 4.3e-61 206.4 0.0 5.3e-61 206.1 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family Glyoxalase PF00903.25 EXF73364.1 - 4.4e-09 36.6 4.6 0.0014 18.9 3.9 2.9 2 1 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily adh_short_C2 PF13561.6 EXF73365.1 - 1.1e-45 156.1 0.0 1.7e-45 155.4 0.0 1.2 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF73365.1 - 3.5e-37 127.8 0.0 4.7e-37 127.4 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EXF73365.1 - 1.7e-06 28.1 0.0 3e-05 24.0 0.0 2.1 1 1 0 1 1 1 1 KR domain p450 PF00067.22 EXF73366.1 - 9.5e-37 126.8 0.0 1.1e-36 126.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 FAD_binding_3 PF01494.19 EXF73367.1 - 9.5e-14 51.4 3.7 3.7e-13 49.4 0.5 2.7 2 1 0 2 2 2 1 FAD binding domain SE PF08491.10 EXF73367.1 - 1.6e-06 27.4 0.0 1.3e-05 24.4 0.0 2.2 1 1 0 1 1 1 1 Squalene epoxidase NAD_binding_8 PF13450.6 EXF73367.1 - 5.3e-05 23.4 0.2 0.00014 22.0 0.2 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EXF73367.1 - 6.4e-05 22.7 1.5 0.00017 21.3 0.6 2.0 1 1 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EXF73367.1 - 0.049 12.9 0.4 0.091 12.0 0.2 1.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EXF73367.1 - 0.076 12.1 0.6 0.13 11.3 0.6 1.4 1 0 0 1 1 1 0 FAD binding domain Cys_Met_Meta_PP PF01053.20 EXF73368.1 - 1.1e-124 415.9 0.0 1.2e-124 415.7 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 EXF73368.1 - 9e-08 31.8 1.2 1.7e-07 30.9 1.2 1.4 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_1_2 PF00155.21 EXF73368.1 - 9.6e-05 21.7 0.1 0.00016 20.9 0.1 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Met_gamma_lyase PF06838.11 EXF73368.1 - 0.0018 16.9 0.1 0.0026 16.4 0.1 1.2 1 0 0 1 1 1 1 Methionine gamma-lyase Aminotran_5 PF00266.19 EXF73368.1 - 0.0056 15.7 0.3 0.047 12.6 0.2 2.0 1 1 1 2 2 2 1 Aminotransferase class-V SepSecS PF05889.13 EXF73368.1 - 0.015 14.0 0.1 0.023 13.4 0.1 1.2 1 0 0 1 1 1 0 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS Asparaginase_C PF17763.1 EXF73368.1 - 0.039 14.2 0.5 0.21 11.8 0.0 2.1 2 0 0 2 2 2 0 Glutaminase/Asparaginase C-terminal domain TNV_CP PF03898.13 EXF73368.1 - 0.075 12.3 0.1 0.13 11.5 0.1 1.4 1 0 0 1 1 1 0 Satellite tobacco necrosis virus coat protein Beta_elim_lyase PF01212.21 EXF73368.1 - 0.093 12.0 0.6 0.24 10.6 0.6 1.5 1 1 0 1 1 1 0 Beta-eliminating lyase Radical_SAM PF04055.21 EXF73368.1 - 0.11 12.8 0.0 3.8 7.9 0.0 2.4 2 0 0 2 2 2 0 Radical SAM superfamily FAD_binding_3 PF01494.19 EXF73369.1 - 5.4e-18 65.3 1.8 1e-16 61.1 1.8 2.2 1 1 0 1 1 1 1 FAD binding domain FAD_binding_2 PF00890.24 EXF73369.1 - 1.1e-07 31.3 0.1 2e-07 30.5 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EXF73369.1 - 9.2e-07 28.4 0.1 0.00017 20.9 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EXF73369.1 - 2.2e-06 27.5 0.1 0.00013 21.7 0.1 2.4 2 0 0 2 2 2 1 FAD dependent oxidoreductase HI0933_like PF03486.14 EXF73369.1 - 2.2e-05 23.4 0.3 0.0008 18.2 0.1 2.2 2 0 0 2 2 2 1 HI0933-like protein NAD_binding_8 PF13450.6 EXF73369.1 - 3.3e-05 24.0 0.4 9.6e-05 22.5 0.4 1.9 1 1 0 1 1 1 1 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 EXF73369.1 - 0.00013 21.2 0.1 0.0051 15.9 0.0 2.1 2 0 0 2 2 2 1 Glucose inhibited division protein A Pyr_redox_3 PF13738.6 EXF73369.1 - 0.00044 19.6 0.1 0.00081 18.7 0.1 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EXF73369.1 - 0.00098 18.6 0.1 0.0019 17.6 0.1 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 EXF73369.1 - 0.0011 19.5 0.1 0.024 15.2 0.1 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EXF73369.1 - 0.029 13.6 0.1 0.054 12.7 0.1 1.3 1 0 0 1 1 1 0 Thi4 family AlaDh_PNT_C PF01262.21 EXF73369.1 - 0.03 13.6 0.0 0.066 12.5 0.0 1.5 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain 3HCDH_N PF02737.18 EXF73369.1 - 0.04 13.8 0.1 0.078 12.9 0.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Lycopene_cycl PF05834.12 EXF73369.1 - 0.29 10.2 1.7 4.8 6.1 0.0 2.7 3 0 0 3 3 3 0 Lycopene cyclase protein Sugar_tr PF00083.24 EXF73370.1 - 8.1e-78 262.3 14.0 1e-77 262.0 14.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF73370.1 - 1.8e-22 79.8 21.0 1.8e-22 79.8 21.0 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily MFS_1_like PF12832.7 EXF73370.1 - 0.015 14.2 0.0 0.015 14.2 0.0 2.9 2 1 1 3 3 3 0 MFS_1 like family Rab5ip PF07019.12 EXF73370.1 - 0.26 11.9 5.5 1.3 9.6 5.5 2.3 1 0 0 1 1 1 0 Rab5-interacting protein (Rab5ip) But2 PF09792.9 EXF73371.1 - 1.1e-31 110.1 1.0 2.3e-31 109.1 0.6 1.6 2 0 0 2 2 2 1 Ubiquitin 3 binding protein But2 C-terminal domain PAP2_3 PF14378.6 EXF73372.1 - 3.8e-36 124.6 9.1 3.8e-36 124.6 9.1 1.5 2 0 0 2 2 2 1 PAP2 superfamily PAP2 PF01569.21 EXF73372.1 - 0.0011 18.8 2.9 0.0011 18.8 2.9 1.9 2 0 0 2 2 2 1 PAP2 superfamily PAP2_C PF14360.6 EXF73372.1 - 0.0043 17.6 0.1 0.0043 17.6 0.1 2.8 3 1 0 3 3 3 1 PAP2 superfamily C-terminal Glyco_hydro_28 PF00295.17 EXF73373.1 - 6.8e-37 127.2 2.1 9.7e-37 126.7 2.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 Cytomega_UL20A PF05984.12 EXF73374.1 - 0.15 12.4 0.0 0.21 11.9 0.0 1.2 1 0 0 1 1 1 0 Cytomegalovirus UL20A protein SGL PF08450.12 EXF73375.1 - 3.3e-11 43.2 0.3 2.3e-08 33.9 0.0 2.8 2 2 1 3 3 3 2 SMP-30/Gluconolactonase/LRE-like region NHL PF01436.21 EXF73375.1 - 0.018 15.0 0.0 5.8 7.2 0.0 3.1 3 0 0 3 3 3 0 NHL repeat TPT PF03151.16 EXF73376.1 - 0.044 13.1 0.0 0.053 12.9 0.0 1.1 1 0 0 1 1 1 0 Triose-phosphate Transporter family Pkinase PF00069.25 EXF73377.1 - 1.3e-73 247.6 0.0 2e-73 247.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF73377.1 - 2.7e-37 128.5 0.0 6.8e-37 127.1 0.0 1.7 2 1 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 EXF73377.1 - 0.00062 19.2 0.3 1 8.6 0.0 2.6 3 0 0 3 3 3 2 Kinase-like APH PF01636.23 EXF73377.1 - 0.018 15.0 0.0 0.12 12.2 0.0 2.2 2 1 1 3 3 3 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EXF73377.1 - 0.021 13.6 0.7 0.074 11.8 0.0 2.1 2 0 0 2 2 2 0 Fungal protein kinase Fungal_trans_2 PF11951.8 EXF73378.1 - 6.7e-50 170.0 8.8 1.8e-49 168.6 8.8 1.6 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF73378.1 - 4.4e-07 29.9 7.3 1e-06 28.8 7.3 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RVT_1 PF00078.27 EXF73379.1 - 6.4e-07 29.1 0.0 1.3e-06 28.1 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) MFS_1 PF07690.16 EXF73380.1 - 6.3e-42 143.8 45.1 6.3e-42 143.8 45.1 1.7 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF73380.1 - 3.5e-15 55.8 9.1 3.5e-15 55.8 9.1 2.6 2 1 1 3 3 3 1 Sugar (and other) transporter TRI12 PF06609.13 EXF73380.1 - 0.00086 17.9 19.2 0.0013 17.3 19.2 1.4 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) AMP-binding PF00501.28 EXF73381.1 - 1.4e-15 56.8 0.0 6.5e-15 54.6 0.0 1.8 1 1 0 1 1 1 1 AMP-binding enzyme NPCC PF08058.11 EXF73382.1 - 6.8e-29 100.6 0.0 9.1e-29 100.1 0.0 1.2 1 0 0 1 1 1 1 Nuclear pore complex component US30 PF17624.2 EXF73382.1 - 1.3 8.0 4.1 0.5 9.4 1.5 1.5 2 0 0 2 2 2 0 Family of unknown function Hid1 PF12722.7 EXF73383.1 - 0 1035.1 0.0 0 1034.9 0.0 1.0 1 0 0 1 1 1 1 High-temperature-induced dauer-formation protein Dymeclin PF09742.9 EXF73383.1 - 1.1e-105 354.4 0.0 1.4e-105 354.1 0.0 1.0 1 0 0 1 1 1 1 Dyggve-Melchior-Clausen syndrome protein DUF913 PF06025.12 EXF73383.1 - 0.016 14.2 0.3 0.059 12.3 0.3 1.8 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) Adeno_GP19K PF04881.13 EXF73383.1 - 0.084 12.9 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 Adenovirus GP19K EHN PF06441.12 EXF73384.1 - 1.2e-27 96.4 0.5 2.2e-27 95.5 0.5 1.4 1 0 0 1 1 1 1 Epoxide hydrolase N terminus TaqI_C PF12950.7 EXF73384.1 - 0.023 14.8 0.0 0.04 14.0 0.0 1.3 1 0 0 1 1 1 0 TaqI-like C-terminal specificity domain DUF3720 PF12517.8 EXF73384.1 - 0.92 10.5 3.8 6.6 7.7 0.7 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3720) TIMELESS PF04821.14 EXF73385.1 - 1.9e-87 293.1 0.2 1.9e-87 293.1 0.2 2.7 3 0 0 3 3 3 1 Timeless protein TIMELESS_C PF05029.13 EXF73385.1 - 8.3e-34 117.7 29.7 8.3e-34 117.7 29.7 3.3 2 1 0 2 2 2 1 Timeless protein C terminal region AAA_16 PF13191.6 EXF73385.1 - 0.29 11.5 2.9 1.1 9.6 1.3 2.7 2 0 0 2 2 2 0 AAA ATPase domain Cnd1_N PF12922.7 EXF73385.1 - 2.6 7.9 5.6 14 5.5 0.1 3.1 3 0 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1, N-term 3HCDH_N PF02737.18 EXF73386.1 - 1.4e-52 178.2 0.9 2e-52 177.7 0.9 1.2 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 EXF73386.1 - 1.5e-34 118.5 0.0 3.2e-34 117.4 0.0 1.6 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain Sacchrp_dh_NADP PF03435.18 EXF73386.1 - 2.8e-05 24.4 0.1 5.4e-05 23.5 0.1 1.5 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_2 PF03446.15 EXF73386.1 - 0.00078 19.7 0.2 0.0026 17.9 0.1 1.9 1 1 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Pyr_redox_2 PF07992.14 EXF73386.1 - 0.0017 17.6 0.0 0.0023 17.2 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EXF73386.1 - 0.0022 17.6 0.0 0.003 17.2 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase UDPG_MGDP_dh_N PF03721.14 EXF73386.1 - 0.03 13.9 0.1 0.055 13.0 0.1 1.5 1 1 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain AlaDh_PNT_C PF01262.21 EXF73386.1 - 0.032 13.5 0.3 0.065 12.5 0.3 1.5 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.19 EXF73386.1 - 0.14 11.5 0.4 0.31 10.4 0.2 1.6 1 1 1 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain F420_oxidored PF03807.17 EXF73386.1 - 0.28 11.8 2.6 1.8 9.2 2.5 2.4 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Homeodomain PF00046.29 EXF73388.1 - 8.3e-18 64.0 3.0 1.6e-17 63.1 3.0 1.5 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EXF73388.1 - 0.0046 16.8 0.1 0.012 15.5 0.1 1.7 1 0 0 1 1 1 1 Homeobox KN domain NUP50 PF08911.11 EXF73388.1 - 6 7.6 8.2 0.43 11.3 0.5 2.9 2 0 0 2 2 2 0 NUP50 (Nucleoporin 50 kDa) MFS_1 PF07690.16 EXF73389.1 - 9e-24 84.0 35.5 1.2e-23 83.6 35.5 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Fungal_trans_2 PF11951.8 EXF73392.1 - 2.4e-07 29.9 0.0 3.4e-07 29.4 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Peptidase_C50 PF03568.17 EXF73393.1 - 1.3e-161 538.2 0.0 3.9e-161 536.6 0.0 1.9 2 0 0 2 2 2 1 Peptidase family C50 TPR_12 PF13424.6 EXF73393.1 - 5.5e-06 26.6 29.1 0.031 14.5 2.6 6.6 7 0 0 7 7 7 3 Tetratricopeptide repeat CHAT PF12770.7 EXF73393.1 - 2.2e-05 24.0 1.3 0.0079 15.6 0.0 3.9 3 1 0 3 3 3 1 CHAT domain TPR_7 PF13176.6 EXF73393.1 - 0.025 14.6 3.4 2.1 8.6 0.1 4.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 EXF73393.1 - 0.15 12.6 17.6 3.9 8.1 0.0 6.1 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_16 PF13432.6 EXF73393.1 - 0.58 10.8 6.5 0.69 10.6 2.9 3.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_4 PF07721.14 EXF73393.1 - 0.93 10.3 8.0 25 5.9 0.0 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_2 PF07719.17 EXF73393.1 - 1.3 9.3 24.3 3.3 8.0 0.2 7.0 8 0 0 8 8 8 0 Tetratricopeptide repeat TPR_10 PF13374.6 EXF73393.1 - 9.2 6.3 11.3 58 3.7 0.1 5.2 5 0 0 5 5 5 0 Tetratricopeptide repeat DUF5321 PF17254.2 EXF73394.1 - 1.8e-61 206.2 2.4 2.2e-61 206.0 2.4 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5321) Peptidase_C10 PF01640.17 EXF73394.1 - 0.13 12.6 0.1 0.25 11.6 0.0 1.4 2 0 0 2 2 2 0 Peptidase C10 family DUF3708 PF12501.8 EXF73394.1 - 0.48 10.2 3.2 0.19 11.5 0.5 1.6 2 0 0 2 2 2 0 Phosphate ATP-binding cassette transporter SIR2 PF02146.17 EXF73395.1 - 1e-31 110.2 0.0 1.5e-31 109.7 0.0 1.2 1 0 0 1 1 1 1 Sir2 family Cation_efflux PF01545.21 EXF73396.1 - 1.8e-48 164.9 7.2 2.5e-48 164.5 7.2 1.2 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 EXF73396.1 - 3.4e-05 23.9 0.6 8.1e-05 22.7 0.1 1.9 2 0 0 2 2 2 1 Dimerisation domain of Zinc Transporter FGGY_C PF02782.16 EXF73397.1 - 3.1e-28 98.8 0.0 5e-28 98.2 0.0 1.3 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 EXF73397.1 - 8.9e-20 71.3 0.0 5.9e-12 45.7 0.0 2.2 2 0 0 2 2 2 2 FGGY family of carbohydrate kinases, N-terminal domain SRP-alpha_N PF04086.13 EXF73397.1 - 0.013 15.5 0.1 0.02 14.8 0.1 1.3 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal HEAT PF02985.22 EXF73399.1 - 0.001 19.1 5.3 7 7.2 0.0 5.4 6 0 0 6 6 6 2 HEAT repeat HEAT_EZ PF13513.6 EXF73399.1 - 0.0047 17.4 2.2 0.29 11.7 0.0 4.7 5 0 0 5 5 5 1 HEAT-like repeat Nitr_red_assoc PF09655.10 EXF73399.1 - 0.0054 17.4 2.1 1.4 9.5 0.1 3.1 3 0 0 3 3 3 2 Conserved nitrate reductase-associated protein (Nitr_red_assoc) F_actin_bind PF08919.10 EXF73399.1 - 0.018 15.1 2.3 0.69 10.0 0.0 3.9 5 0 0 5 5 5 0 F-actin binding HEAT_2 PF13646.6 EXF73399.1 - 0.021 15.2 4.3 0.61 10.5 0.1 4.6 5 0 0 5 5 5 0 HEAT repeats Cnd1 PF12717.7 EXF73399.1 - 0.045 13.8 3.5 0.74 9.8 0.1 4.4 5 2 0 5 5 5 0 non-SMC mitotic condensation complex subunit 1 RNase_H PF00075.24 EXF73400.1 - 3.9e-19 69.3 0.0 6.5e-19 68.5 0.0 1.3 1 0 0 1 1 1 1 RNase H Ribosomal_L1 PF00687.21 EXF73401.1 - 2.8e-45 154.6 0.1 3.3e-45 154.4 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family SNF PF00209.18 EXF73401.1 - 0.11 11.2 0.1 0.15 10.8 0.1 1.1 1 0 0 1 1 1 0 Sodium:neurotransmitter symporter family DUF2428 PF10350.9 EXF73402.1 - 3.1e-59 200.5 0.0 8.5e-59 199.1 0.0 1.8 1 0 0 1 1 1 1 Putative death-receptor fusion protein (DUF2428) HEAT PF02985.22 EXF73402.1 - 0.0005 20.1 12.6 0.088 13.1 0.0 6.8 6 0 0 6 6 6 1 HEAT repeat DUF4050 PF13259.6 EXF73402.1 - 0.12 12.7 0.8 0.36 11.1 0.8 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) HEAT_EZ PF13513.6 EXF73402.1 - 0.74 10.4 9.1 0.26 11.8 0.6 4.3 5 0 0 5 5 5 0 HEAT-like repeat DUF3074 PF11274.8 EXF73403.1 - 7.7e-60 202.0 1.2 3.5e-58 196.6 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF3074) Caldesmon PF02029.15 EXF73403.1 - 6.9e-05 21.8 24.5 0.00012 21.0 24.5 1.3 1 0 0 1 1 1 1 Caldesmon Spc7 PF08317.11 EXF73403.1 - 0.09 11.6 25.1 0.23 10.3 25.1 1.6 1 0 0 1 1 1 0 Spc7 kinetochore protein VASt PF16016.5 EXF73404.1 - 9.8e-39 133.2 2.0 2.9e-38 131.7 2.0 1.9 1 0 0 1 1 1 1 VAD1 Analog of StAR-related lipid transfer domain BAR_3 PF16746.5 EXF73404.1 - 7.3e-17 61.9 0.0 1.4e-16 61.0 0.0 1.4 1 0 0 1 1 1 1 BAR domain of APPL family PH PF00169.29 EXF73404.1 - 1.1e-05 25.9 0.1 2.4e-05 24.8 0.1 1.6 1 0 0 1 1 1 1 PH domain DUF639 PF04842.12 EXF73404.1 - 0.011 15.2 1.2 0.023 14.1 1.2 1.4 1 0 0 1 1 1 0 Plant protein of unknown function (DUF639) GRAM PF02893.20 EXF73404.1 - 0.043 13.7 0.0 0.099 12.5 0.0 1.5 1 0 0 1 1 1 0 GRAM domain NERD PF08378.11 EXF73406.1 - 0.17 12.3 0.2 0.9 10.0 0.1 1.9 2 0 0 2 2 2 0 Nuclease-related domain DUF2183 PF09949.9 EXF73407.1 - 3.2e-22 78.7 0.1 6.9e-22 77.6 0.1 1.6 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2183) RTP1_C1 PF10363.9 EXF73408.1 - 3.5e-24 85.2 2.8 5.5e-24 84.5 0.2 2.8 3 1 1 4 4 4 1 Required for nuclear transport of RNA pol II C-terminus 1 RTP1_C2 PF10304.9 EXF73408.1 - 7e-15 54.4 0.8 2.1e-14 52.8 0.8 1.9 1 0 0 1 1 1 1 Required for nuclear transport of RNA pol II C-terminus 2 Adaptin_N PF01602.20 EXF73408.1 - 0.025 13.1 0.1 0.065 11.8 0.1 1.7 1 0 0 1 1 1 0 Adaptin N terminal region Cnd1 PF12717.7 EXF73408.1 - 0.026 14.6 1.5 0.64 10.0 0.0 2.9 2 1 1 3 3 3 0 non-SMC mitotic condensation complex subunit 1 DnaG_DnaB_bind PF08278.11 EXF73408.1 - 0.03 14.9 0.8 2.1 9.0 0.1 3.0 2 0 0 2 2 2 0 DNA primase DnaG DnaB-binding RNA_pol_Rpc82 PF05645.13 EXF73408.1 - 0.066 13.0 0.1 0.13 12.0 0.1 1.4 1 0 0 1 1 1 0 RNA polymerase III subunit RPC82 DNA_alkylation PF08713.11 EXF73408.1 - 0.07 12.8 0.0 0.31 10.7 0.0 2.0 2 0 0 2 2 2 0 DNA alkylation repair enzyme AT_hook PF02178.19 EXF73409.1 - 0.22 11.5 23.3 0.086 12.8 2.5 3.5 3 0 0 3 3 3 0 AT hook motif Thr_synth_N PF14821.6 EXF73410.1 - 1.7e-27 95.5 0.0 4e-27 94.2 0.0 1.7 1 0 0 1 1 1 1 Threonine synthase N terminus PALP PF00291.25 EXF73410.1 - 2e-19 70.2 0.0 2.4e-18 66.6 0.0 2.0 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme KASH_CCD PF14662.6 EXF73412.1 - 3.7e-05 23.6 6.6 0.00094 19.1 0.7 2.5 2 1 0 2 2 2 2 Coiled-coil region of CCDC155 or KASH ADIP PF11559.8 EXF73412.1 - 0.0025 17.9 10.0 0.0053 16.8 5.5 2.1 2 0 0 2 2 2 1 Afadin- and alpha -actinin-Binding ZapB PF06005.12 EXF73412.1 - 0.088 13.3 13.4 1.2 9.6 0.3 3.1 2 1 0 2 2 2 0 Cell division protein ZapB Fib_alpha PF08702.10 EXF73412.1 - 0.099 12.8 0.0 1.1 9.4 0.0 2.1 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family GAS PF13851.6 EXF73412.1 - 0.1 11.9 4.3 4.5 6.6 0.8 2.4 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding Mito_fiss_reg PF05308.11 EXF73412.1 - 0.13 12.4 1.1 0.21 11.6 1.1 1.4 1 0 0 1 1 1 0 Mitochondrial fission regulator YabA PF06156.13 EXF73412.1 - 0.27 11.9 4.3 5.6 7.7 0.9 2.7 1 1 1 2 2 2 0 Initiation control protein YabA ATG16 PF08614.11 EXF73412.1 - 0.47 10.7 9.0 0.19 11.9 2.6 2.3 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) CAP_N PF01213.19 EXF73412.1 - 0.8 9.1 5.6 1.3 8.5 5.6 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal APG6_N PF17675.1 EXF73412.1 - 1.3 9.5 6.4 0.45 11.0 1.7 2.1 2 0 0 2 2 2 0 Apg6 coiled-coil region SelP_N PF04592.14 EXF73412.1 - 4.6 6.6 13.3 1.6 8.1 4.4 2.2 2 0 0 2 2 2 0 Selenoprotein P, N terminal region ABM PF03992.16 EXF73413.1 - 6.3e-06 26.2 0.1 2.5e-05 24.3 0.0 1.9 2 0 0 2 2 2 1 Antibiotic biosynthesis monooxygenase FAD_binding_4 PF01565.23 EXF73414.1 - 7.3e-25 87.3 0.2 1.1e-24 86.7 0.2 1.3 1 0 0 1 1 1 1 FAD binding domain FAD-oxidase_C PF02913.19 EXF73414.1 - 4.6e-08 33.0 0.0 6.6e-08 32.5 0.0 1.2 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain Ferritin_2 PF13668.6 EXF73415.1 - 7.4e-17 61.8 0.1 1.3e-16 61.1 0.1 1.4 1 0 0 1 1 1 1 Ferritin-like domain FKBP_C PF00254.28 EXF73416.1 - 9.6e-34 115.6 0.0 1.4e-33 115.1 0.0 1.3 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase F420_oxidored PF03807.17 EXF73417.1 - 2.4e-05 24.9 0.1 4e-05 24.1 0.1 1.3 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 EXF73417.1 - 8.4e-05 22.8 0.0 0.00012 22.3 0.0 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh_C PF02826.19 EXF73417.1 - 0.00094 18.6 0.0 0.0015 17.9 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain PDH PF02153.17 EXF73417.1 - 0.0031 16.6 0.0 0.0046 16.0 0.0 1.2 1 0 0 1 1 1 1 Prephenate dehydrogenase IlvN PF07991.12 EXF73417.1 - 0.008 15.8 0.1 0.014 15.0 0.1 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain Mut7-C PF01927.16 EXF73417.1 - 0.014 15.5 0.0 0.024 14.7 0.0 1.3 1 0 0 1 1 1 0 Mut7-C RNAse domain DUF1932 PF09130.11 EXF73417.1 - 0.021 14.8 0.0 0.15 12.1 0.0 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF1932) 3HCDH_N PF02737.18 EXF73417.1 - 0.03 14.2 0.1 0.051 13.5 0.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain RPEL PF02755.15 EXF73419.1 - 5.6e-23 79.9 2.2 4.6e-11 42.0 0.2 2.4 2 0 0 2 2 2 2 RPEL repeat HET PF06985.11 EXF73420.1 - 2.5e-11 44.1 7.6 9.5e-10 39.0 1.4 2.6 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) adh_short PF00106.25 EXF73421.1 - 2.7e-37 128.1 0.3 3.4e-37 127.8 0.3 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF73421.1 - 3.1e-31 108.7 0.6 4e-31 108.4 0.6 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF73421.1 - 1e-11 45.1 0.1 1.3e-11 44.7 0.1 1.1 1 0 0 1 1 1 1 KR domain Eno-Rase_NADH_b PF12242.8 EXF73421.1 - 0.082 12.7 1.6 0.14 11.9 1.4 1.5 1 1 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Peptidase_M14 PF00246.24 EXF73422.1 - 9.9e-38 130.6 0.2 1.5e-37 130.0 0.2 1.2 1 0 0 1 1 1 1 Zinc carboxypeptidase Amidase PF01425.21 EXF73423.1 - 1.1e-67 229.0 0.0 2.1e-65 221.5 0.0 2.1 1 1 0 1 1 1 1 Amidase Cupin_3 PF05899.12 EXF73423.1 - 9e-05 22.1 0.0 0.00033 20.3 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF861) EutQ PF06249.12 EXF73423.1 - 0.0037 17.0 0.0 0.0067 16.2 0.0 1.3 1 0 0 1 1 1 1 Ethanolamine utilisation protein EutQ BBE PF08031.12 EXF73424.1 - 0.0012 18.9 0.2 0.0022 18.0 0.2 1.4 1 0 0 1 1 1 1 Berberine and berberine like MOSC PF03473.17 EXF73425.1 - 4.3e-22 78.5 0.0 6.2e-22 78.0 0.0 1.2 1 0 0 1 1 1 1 MOSC domain MOSC_N PF03476.16 EXF73425.1 - 9.5e-10 38.4 0.0 1.8e-09 37.5 0.0 1.6 1 1 0 1 1 1 1 MOSC N-terminal beta barrel domain NAD_binding_10 PF13460.6 EXF73426.1 - 1.5e-16 60.8 0.1 5.2e-16 59.1 0.1 1.8 1 1 1 2 2 2 1 NAD(P)H-binding NmrA PF05368.13 EXF73426.1 - 2.6e-13 50.1 0.4 4.3e-13 49.4 0.4 1.2 1 0 0 1 1 1 1 NmrA-like family Shikimate_DH PF01488.20 EXF73426.1 - 1.8e-06 28.1 0.0 3.3e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_2 PF03446.15 EXF73426.1 - 9.4e-05 22.6 0.0 0.00017 21.8 0.0 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 3HCDH_N PF02737.18 EXF73426.1 - 0.0004 20.3 0.1 0.00067 19.6 0.1 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain LytR_C PF13399.6 EXF73426.1 - 0.014 16.3 0.8 0.073 14.1 0.1 2.2 2 0 0 2 2 2 0 LytR cell envelope-related transcriptional attenuator NAD_Gly3P_dh_N PF01210.23 EXF73426.1 - 0.016 15.2 0.1 0.034 14.1 0.0 1.5 1 1 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Zn_clus PF00172.18 EXF73427.1 - 3.5e-10 39.9 8.4 7.6e-10 38.8 8.4 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EXF73427.1 - 1.5e-05 24.2 0.1 2.4e-05 23.5 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain PLA2_B PF01735.18 EXF73428.1 - 2.5e-84 283.5 4.5 7.9e-84 281.8 4.5 1.7 1 1 0 1 1 1 1 Lysophospholipase catalytic domain PHP PF02811.19 EXF73429.1 - 4.1e-10 40.2 0.0 2.2e-09 37.8 0.0 1.9 1 1 0 1 1 1 1 PHP domain Hist_deacetyl PF00850.19 EXF73430.1 - 2.3e-51 175.1 0.0 3.6e-51 174.5 0.0 1.3 1 0 0 1 1 1 1 Histone deacetylase domain RTP801_C PF07809.11 EXF73430.1 - 0.00033 20.6 0.0 0.00071 19.5 0.0 1.5 1 0 0 1 1 1 1 RTP801 C-terminal region Adaptin_binding PF10199.9 EXF73430.1 - 0.041 14.5 1.8 0.092 13.4 1.8 1.6 1 0 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 Haspin_kinase PF12330.8 EXF73430.1 - 0.41 9.5 1.9 0.68 8.8 1.9 1.3 1 0 0 1 1 1 0 Haspin like kinase domain TGT PF01702.18 EXF73432.1 - 1.6e-138 461.6 0.0 1.9e-138 461.4 0.0 1.0 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase Mit_ribos_Mrp51 PF11709.8 EXF73433.1 - 1.5e-129 432.8 0.0 1.8e-129 432.5 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein subunit Ribosomal_S17e PF00833.18 EXF73434.1 - 3.4e-59 198.1 0.2 4.2e-59 197.8 0.2 1.0 1 0 0 1 1 1 1 Ribosomal S17 RPAP2_Rtr1 PF04181.13 EXF73435.1 - 5.6e-23 81.1 0.1 1.1e-22 80.1 0.1 1.5 1 0 0 1 1 1 1 Rtr1/RPAP2 family SH3_1 PF00018.28 EXF73436.1 - 3.8e-08 32.8 0.1 3.8e-08 32.8 0.1 2.0 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.17 EXF73436.1 - 9.3e-07 28.4 0.0 1.7e-06 27.6 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 EXF73436.1 - 2.1e-06 27.5 0.1 4.5e-06 26.4 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain DNase-RNase PF02577.14 EXF73436.1 - 0.13 11.9 0.0 0.23 11.1 0.0 1.3 1 0 0 1 1 1 0 Bifunctional nuclease p450 PF00067.22 EXF73437.1 - 9.5e-24 84.0 0.0 2.5e-23 82.6 0.0 1.4 1 1 1 2 2 2 1 Cytochrome P450 VASP_tetra PF08776.11 EXF73437.1 - 0.028 14.0 0.6 0.052 13.1 0.6 1.4 1 0 0 1 1 1 0 VASP tetramerisation domain p450 PF00067.22 EXF73438.1 - 2.9e-53 181.2 0.0 4e-53 180.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 ADH_zinc_N PF00107.26 EXF73439.1 - 1.2e-07 31.8 0.0 2e-07 31.0 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EXF73439.1 - 5.8e-07 29.4 0.2 3.6e-06 26.8 0.3 2.1 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 EXF73439.1 - 0.022 15.8 0.0 0.039 15.0 0.0 1.4 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Condensation PF00668.20 EXF73440.1 - 3.4e-08 32.6 0.4 5.8e-08 31.8 0.4 1.3 1 0 0 1 1 1 1 Condensation domain MutS_II PF05188.17 EXF73441.1 - 0.16 12.2 1.8 0.18 12.0 0.2 1.9 2 0 0 2 2 2 0 MutS domain II zf-C2H2 PF00096.26 EXF73442.1 - 0.002 18.5 0.5 0.002 18.5 0.5 3.7 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-met PF12874.7 EXF73442.1 - 0.19 12.2 1.6 0.7 10.4 0.2 2.5 2 0 0 2 2 2 0 Zinc-finger of C2H2 type IBR PF01485.21 EXF73442.1 - 0.4 10.9 10.8 3.5 7.9 0.1 3.0 3 0 0 3 3 3 0 IBR domain, a half RING-finger domain Pkinase PF00069.25 EXF73445.1 - 6.2e-36 124.1 0.0 8.9e-36 123.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF73445.1 - 1e-17 64.3 0.0 2.4e-17 63.1 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 EXF73445.1 - 6.2e-05 22.4 0.0 0.00011 21.7 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EXF73445.1 - 0.019 14.9 0.1 0.055 13.4 0.0 1.7 1 1 0 1 1 1 0 Phosphotransferase enzyme family Methyltransf_11 PF08241.12 EXF73447.1 - 4.8e-16 59.2 0.0 7.3e-16 58.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF73447.1 - 1.7e-15 57.5 0.0 2.6e-15 56.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EXF73447.1 - 6.4e-14 51.8 0.0 9.5e-14 51.3 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.6 EXF73447.1 - 1.4e-12 47.7 0.0 1.8e-12 47.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF73447.1 - 6.1e-08 33.3 0.0 9.1e-08 32.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EXF73447.1 - 1.2e-06 28.5 0.0 1.6e-06 28.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 EXF73447.1 - 4e-05 23.6 0.0 0.00025 21.0 0.0 2.0 2 0 0 2 2 2 1 Hypothetical methyltransferase MTS PF05175.14 EXF73447.1 - 0.02 14.4 0.0 0.032 13.8 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain PCMT PF01135.19 EXF73447.1 - 0.077 12.7 0.0 0.11 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MetW PF07021.12 EXF73447.1 - 0.11 12.0 0.0 1.1 8.8 0.0 2.1 1 1 0 1 1 1 0 Methionine biosynthesis protein MetW Methyltr_RsmB-F PF01189.17 EXF73447.1 - 0.15 11.7 0.0 0.25 10.9 0.0 1.3 1 0 0 1 1 1 0 16S rRNA methyltransferase RsmB/F Ank_2 PF12796.7 EXF73448.1 - 1.1e-17 64.4 1.3 7.9e-10 39.2 0.1 3.7 3 1 1 4 4 4 3 Ankyrin repeats (3 copies) Ank PF00023.30 EXF73448.1 - 1.5e-16 60.0 3.4 0.00078 19.8 0.0 5.5 5 0 0 5 5 5 3 Ankyrin repeat Ank_5 PF13857.6 EXF73448.1 - 4.4e-15 55.5 0.4 2.9e-06 27.4 0.0 4.2 2 1 2 4 4 4 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EXF73448.1 - 2.1e-14 52.2 2.5 0.0011 19.2 0.0 5.8 5 0 0 5 5 5 3 Ankyrin repeat Ank_4 PF13637.6 EXF73448.1 - 9.5e-13 48.4 0.2 0.00053 20.5 0.0 4.8 2 2 3 5 5 5 5 Ankyrin repeats (many copies) COG2 PF06148.11 EXF73448.1 - 0.076 13.1 1.3 0.4 10.8 0.0 2.2 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 LysM PF01476.20 EXF73449.1 - 9.3e-21 73.6 0.9 6.5e-10 38.9 0.3 2.1 2 0 0 2 2 2 2 LysM domain Peptidase_S8 PF00082.22 EXF73451.1 - 3.3e-30 105.4 17.6 4.1e-30 105.1 17.6 1.2 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 EXF73451.1 - 2.1e-17 63.5 0.1 3.8e-17 62.7 0.1 1.4 1 0 0 1 1 1 1 Peptidase inhibitor I9 Pyr_redox_2 PF07992.14 EXF73453.1 - 7.1e-37 127.2 0.0 8.3e-37 127.0 0.0 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EXF73453.1 - 1.8e-07 31.6 0.1 7.3e-07 29.7 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EXF73453.1 - 0.099 11.9 0.9 3.4 6.8 0.8 2.2 1 1 1 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Fungal_trans_2 PF11951.8 EXF73454.1 - 1.7e-20 73.2 1.8 3.1e-20 72.4 1.8 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF73454.1 - 1.6e-05 24.9 9.7 1.6e-05 24.9 9.7 1.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain adh_short PF00106.25 EXF73455.1 - 4.4e-28 98.1 0.0 5.9e-28 97.7 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF73455.1 - 6.7e-19 68.4 0.0 7.9e-19 68.1 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 EXF73455.1 - 2.2e-05 24.1 0.0 0.0001 21.8 0.0 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family KR PF08659.10 EXF73455.1 - 0.00068 19.6 0.0 0.0011 19.0 0.0 1.3 1 0 0 1 1 1 1 KR domain Lactococcin PF04369.13 EXF73455.1 - 0.0025 17.9 0.1 0.022 14.9 0.0 2.1 2 0 0 2 2 2 1 Lactococcin-like family GDP_Man_Dehyd PF16363.5 EXF73455.1 - 0.0032 16.9 0.1 0.047 13.1 0.1 2.1 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NADH-UOR_E PF16514.5 EXF73455.1 - 0.1 12.9 0.1 1.3 9.4 0.1 2.3 2 0 0 2 2 2 0 putative NADH-ubiquinone oxidoreductase chain E NAD_binding_10 PF13460.6 EXF73455.1 - 0.11 12.3 0.1 0.36 10.7 0.1 1.9 1 1 0 1 1 1 0 NAD(P)H-binding Aa_trans PF01490.18 EXF73456.1 - 2.8e-39 135.0 32.8 3.2e-39 134.8 32.8 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Herpes_teg_N PF04843.12 EXF73456.1 - 0.02 14.6 0.0 0.076 12.7 0.0 1.8 2 0 0 2 2 2 0 Herpesvirus tegument protein, N-terminal conserved region HsbA PF12296.8 EXF73457.1 - 7.8e-16 58.6 1.6 7.8e-16 58.6 1.6 2.2 2 0 0 2 2 2 1 Hydrophobic surface binding protein A Med3 PF11593.8 EXF73457.1 - 3.4 6.8 11.9 5.6 6.1 11.9 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal peroxidase PF00141.23 EXF73459.1 - 3.7e-30 105.3 0.2 4.9e-30 104.9 0.2 1.3 1 0 0 1 1 1 1 Peroxidase Peroxidase_ext PF11895.8 EXF73459.1 - 7e-06 25.9 0.2 1.8e-05 24.5 0.0 1.8 2 0 0 2 2 2 1 Fungal peroxidase extension region Zn_clus PF00172.18 EXF73460.1 - 2.4e-08 34.0 8.9 3.8e-08 33.3 8.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EXF73460.1 - 2.6e-05 23.2 0.0 3.5e-05 22.8 0.0 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain CAS_CSE1 PF03378.15 EXF73460.1 - 0.023 13.2 0.2 0.033 12.7 0.2 1.1 1 0 0 1 1 1 0 CAS/CSE protein, C-terminus RTA1 PF04479.13 EXF73461.1 - 4.5e-62 209.3 11.7 3e-59 200.1 10.5 2.4 2 1 0 2 2 2 2 RTA1 like protein YchF-GTPase_C PF06071.13 EXF73463.1 - 2e-36 124.0 0.0 4.6e-36 122.9 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.23 EXF73463.1 - 4.6e-21 75.0 0.0 1.2e-20 73.7 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EXF73463.1 - 9.8e-08 31.7 0.0 1.9e-07 30.7 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B Arginosuc_synth PF00764.19 EXF73464.1 - 1e-150 502.4 0.0 1.1e-150 502.2 0.0 1.0 1 0 0 1 1 1 1 Arginosuccinate synthase QueC PF06508.13 EXF73464.1 - 0.006 16.1 0.0 0.0094 15.5 0.0 1.3 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.16 EXF73464.1 - 0.067 12.0 0.0 0.099 11.4 0.0 1.3 1 0 0 1 1 1 0 tRNA methyl transferase RabGAP-TBC PF00566.18 EXF73467.1 - 3.3e-33 115.2 0.0 4.7e-33 114.6 0.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Ribosomal_S13 PF00416.22 EXF73467.1 - 0.17 12.3 0.2 0.34 11.3 0.2 1.4 1 0 0 1 1 1 0 Ribosomal protein S13/S18 FSA_C PF10479.9 EXF73467.1 - 3.9 5.5 8.6 6.8 4.7 8.6 1.3 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus DIL PF01843.19 EXF73468.1 - 1.7e-32 111.7 0.3 3.4e-32 110.8 0.3 1.5 1 0 0 1 1 1 1 DIL domain Ank_2 PF12796.7 EXF73468.1 - 1.3e-18 67.3 0.0 2.3e-11 44.1 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EXF73468.1 - 6.2e-11 42.6 0.0 5.1e-06 26.9 0.0 3.8 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 EXF73468.1 - 5.5e-09 36.1 0.1 0.0052 17.2 0.0 4.2 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 EXF73468.1 - 1.5e-08 34.7 0.0 5.6e-06 26.5 0.0 2.7 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EXF73468.1 - 2.3e-06 27.5 0.0 0.16 12.6 0.0 3.9 3 0 0 3 3 3 2 Ankyrin repeat Allantoicase PF03561.15 EXF73469.1 - 1.1e-96 320.5 0.1 3.6e-47 160.0 0.0 2.1 2 0 0 2 2 2 2 Allantoicase repeat Cytochrom_B561 PF03188.16 EXF73470.1 - 1.4e-17 64.1 2.3 1.4e-17 64.1 2.3 1.6 2 0 0 2 2 2 1 Eukaryotic cytochrome b561 DUF4006 PF13179.6 EXF73470.1 - 0.0024 17.8 0.1 0.32 10.9 0.1 2.6 2 0 0 2 2 2 1 Family of unknown function (DUF4006) DUF4079 PF13301.6 EXF73470.1 - 0.0067 16.6 13.8 1.4 9.1 0.7 3.2 1 1 2 3 3 3 3 Protein of unknown function (DUF4079) Ni_hydr_CYTB PF01292.20 EXF73470.1 - 0.049 13.2 11.8 0.038 13.6 3.4 2.5 1 1 1 2 2 2 0 Prokaryotic cytochrome b561 DUF4271 PF14093.6 EXF73470.1 - 0.057 13.3 5.1 0.038 13.9 3.5 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4271) DUF2347 PF09804.9 EXF73470.1 - 0.13 11.8 0.1 0.18 11.4 0.1 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) LrgA PF03788.14 EXF73470.1 - 1.3 9.0 9.0 0.084 12.8 0.6 2.8 2 2 1 3 3 3 0 LrgA family PepSY_TM PF03929.16 EXF73470.1 - 6.9 6.2 11.3 0.98 9.0 6.0 2.2 1 1 0 2 2 2 0 PepSY-associated TM region Chs7 PF12271.8 EXF73471.1 - 4.2e-111 370.9 7.2 4.7e-111 370.8 7.2 1.0 1 0 0 1 1 1 1 Chitin synthase export chaperone Herpes_UL20 PF04544.12 EXF73471.1 - 0.019 15.3 0.6 0.019 15.3 0.6 2.3 2 1 0 2 2 2 0 Herpesvirus egress protein UL20 DUF347 PF03988.12 EXF73471.1 - 0.34 11.1 0.0 0.34 11.1 0.0 5.0 5 2 0 5 5 5 0 Repeat of Unknown Function (DUF347) DUF2730 PF10805.8 EXF73472.1 - 0.013 15.6 0.9 0.013 15.6 0.9 7.7 6 2 2 8 8 8 0 Protein of unknown function (DUF2730) Iron_permease PF04120.12 EXF73472.1 - 0.04 13.7 4.6 0.16 11.8 0.6 4.3 2 0 0 2 2 2 0 Low affinity iron permease Vps4_C PF09336.10 EXF73472.1 - 4 7.5 10.3 21 5.2 0.1 5.5 5 2 0 6 6 6 0 Vps4 C terminal oligomerisation domain Ribosomal_S30AE PF02482.19 EXF73472.1 - 5.6 7.8 11.3 2.9 8.7 2.2 4.3 2 0 0 2 2 2 0 Sigma 54 modulation protein / S30EA ribosomal protein tRNA-synt_2b PF00587.25 EXF73473.1 - 8.8e-19 68.1 0.0 1.5e-18 67.4 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 EXF73473.1 - 3.4e-12 46.5 4.2 7.8e-12 45.4 4.2 1.6 1 1 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain Actin PF00022.19 EXF73474.1 - 4.1e-19 68.5 0.0 2.7e-13 49.3 0.0 2.5 2 1 0 2 2 2 2 Actin VP_N-CPKC PF11475.8 EXF73474.1 - 0.37 10.7 1.7 0.8 9.7 1.7 1.5 1 0 0 1 1 1 0 Virion protein N terminal domain GEN1_C PF18380.1 EXF73475.1 - 1.3e-27 96.7 0.1 1e-26 93.9 0.0 2.5 2 0 0 2 2 2 1 Holliday junction resolvase Gen1 C-terminal domain XPG_I PF00867.18 EXF73475.1 - 7.7e-26 90.3 0.0 1.6e-25 89.3 0.0 1.6 1 0 0 1 1 1 1 XPG I-region XPG_I_2 PF12813.7 EXF73475.1 - 0.074 12.5 0.0 0.14 11.6 0.0 1.4 1 0 0 1 1 1 0 XPG domain containing TT1725 PF18324.1 EXF73476.1 - 0.053 13.6 0.0 0.11 12.7 0.0 1.4 1 0 0 1 1 1 0 Hypothetical protein TT1725 ANAPC_CDC26 PF10471.9 EXF73479.1 - 0.0066 17.3 3.2 0.024 15.4 3.2 2.2 1 1 0 1 1 1 1 Anaphase-promoting complex APC subunit CDC26 RGS PF00615.19 EXF73481.1 - 2.7e-10 40.5 0.0 3.6e-10 40.2 0.0 1.1 1 0 0 1 1 1 1 Regulator of G protein signaling domain HofP PF10748.9 EXF73483.1 - 0.082 12.5 0.1 0.2 11.2 0.0 1.6 2 0 0 2 2 2 0 DNA utilization proteins HofP RRM_1 PF00076.22 EXF73484.1 - 4.1e-13 48.9 0.0 1.6e-05 24.6 0.0 3.0 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EXF73484.1 - 0.13 12.4 0.0 0.24 11.5 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif Proteasom_Rpn13 PF04683.13 EXF73485.1 - 4.9e-26 91.1 0.0 7.8e-26 90.5 0.0 1.3 1 0 0 1 1 1 1 Proteasome complex subunit Rpn13 ubiquitin receptor RPN13_C PF16550.5 EXF73485.1 - 8.4e-11 42.0 0.9 4.3e-10 39.8 0.9 2.0 1 1 0 1 1 1 1 UCH-binding domain L27_2 PF09045.10 EXF73485.1 - 0.018 15.0 0.1 0.039 13.9 0.1 1.5 1 0 0 1 1 1 0 L27_2 EF1_GNE PF00736.19 EXF73486.1 - 1.1e-32 112.1 1.1 2.1e-32 111.1 1.1 1.5 1 0 0 1 1 1 1 EF-1 guanine nucleotide exchange domain EF-1_beta_acid PF10587.9 EXF73486.1 - 7.9e-14 51.8 9.6 7.9e-14 51.8 9.6 3.2 5 0 0 5 5 5 1 Eukaryotic elongation factor 1 beta central acidic region Sld5 PF05916.11 EXF73486.1 - 4.5e-12 46.4 0.0 1.1e-11 45.2 0.0 1.7 1 0 0 1 1 1 1 GINS complex protein GST_C PF00043.25 EXF73486.1 - 0.00015 21.9 0.0 0.00059 20.0 0.0 2.1 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EXF73486.1 - 0.00095 19.3 0.5 0.0034 17.5 0.0 2.1 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EXF73486.1 - 0.099 12.7 0.3 0.78 9.8 0.3 2.4 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain DUF211 PF02680.14 EXF73486.1 - 0.18 12.0 1.0 0.31 11.2 0.2 1.7 2 0 0 2 2 2 0 Uncharacterized ArCR, COG1888 Sulfate_transp PF00916.20 EXF73487.1 - 1.1e-56 192.3 12.2 1.7e-56 191.7 12.2 1.2 1 0 0 1 1 1 1 Sulfate permease family cNMP_binding PF00027.29 EXF73487.1 - 1.4e-16 60.3 0.0 3.1e-16 59.2 0.0 1.6 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain STAS PF01740.21 EXF73487.1 - 2.7e-10 39.9 0.0 4.8e-10 39.1 0.0 1.4 1 0 0 1 1 1 1 STAS domain Stk19 PF10494.9 EXF73488.1 - 1.7e-80 270.3 0.0 2e-80 270.0 0.0 1.0 1 0 0 1 1 1 1 Serine-threonine protein kinase 19 Kinesin PF00225.23 EXF73489.1 - 9.3e-94 314.1 0.0 1.6e-93 313.3 0.0 1.3 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EXF73489.1 - 8.4e-21 74.5 0.0 2.4e-20 73.0 0.0 1.7 1 0 0 1 1 1 1 Microtubule binding PKcGMP_CC PF16808.5 EXF73489.1 - 0.016 15.1 1.0 0.016 15.1 1.0 3.7 4 0 0 4 4 4 0 Coiled-coil N-terminus of cGMP-dependent protein kinase ALC PF17527.2 EXF73489.1 - 0.028 14.0 0.3 0.06 13.0 0.3 1.5 1 0 0 1 1 1 0 Phage ALC protein LMP PF04778.12 EXF73489.1 - 0.14 12.1 2.9 1.4 8.8 1.4 2.9 2 0 0 2 2 2 0 LMP repeated region Tho2 PF11262.8 EXF73489.1 - 0.67 9.1 2.4 1.1 8.4 2.4 1.3 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 OmpH PF03938.14 EXF73489.1 - 1.6 9.0 7.4 18 5.6 4.8 2.4 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) HTH_Tnp_Tc5 PF03221.16 EXF73491.1 - 5.9e-07 29.4 1.1 9.8e-07 28.7 0.1 1.9 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain zf-C2H2_4 PF13894.6 EXF73491.1 - 0.0038 17.9 20.3 0.0084 16.9 4.8 4.1 4 0 0 4 4 4 2 C2H2-type zinc finger zf-C2H2 PF00096.26 EXF73491.1 - 0.035 14.6 14.5 1.5 9.5 0.1 3.9 3 0 0 3 3 3 0 Zinc finger, C2H2 type Amidase PF01425.21 EXF73492.1 - 1.7e-90 304.1 0.0 7.8e-90 302.0 0.0 1.8 1 1 0 1 1 1 1 Amidase DUF3237 PF11578.8 EXF73493.1 - 4.5e-29 101.2 0.0 5.2e-29 101.0 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3237) MFS_1 PF07690.16 EXF73494.1 - 5.2e-29 101.3 23.2 5.2e-29 101.3 23.2 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily DUF4338 PF14236.6 EXF73494.1 - 0.19 10.9 0.0 0.33 10.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4338) Peptidase_C13 PF01650.18 EXF73495.1 - 0.14 11.7 0.1 0.2 11.2 0.1 1.2 1 0 0 1 1 1 0 Peptidase C13 family DUF3328 PF11807.8 EXF73498.1 - 8e-15 55.2 0.5 1.8e-14 54.1 0.5 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF3328) Asparaginase PF00710.20 EXF73501.1 - 7.2e-44 149.6 0.0 1e-43 149.1 0.0 1.2 1 0 0 1 1 1 1 Asparaginase, N-terminal Asparaginase_C PF17763.1 EXF73501.1 - 1e-14 54.7 0.0 2.7e-14 53.4 0.0 1.7 1 0 0 1 1 1 1 Glutaminase/Asparaginase C-terminal domain Chromo PF00385.24 EXF73502.1 - 0.038 13.9 0.1 0.11 12.5 0.1 1.7 2 0 0 2 2 2 0 Chromo (CHRromatin Organisation MOdifier) domain Suf PF05843.14 EXF73502.1 - 0.72 9.8 4.9 0.99 9.3 4.9 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Methyltransf_16 PF10294.9 EXF73503.1 - 2e-16 60.2 0.0 3.1e-16 59.6 0.0 1.2 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_12 PF08242.12 EXF73503.1 - 0.0012 19.6 0.0 0.0021 18.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF73503.1 - 0.0041 17.8 0.0 0.009 16.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EXF73503.1 - 0.038 13.5 0.0 0.078 12.5 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase small domain Fungal_trans PF04082.18 EXF73504.1 - 4.7e-21 75.0 0.1 7.9e-21 74.3 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF73504.1 - 1e-07 31.9 7.9 1.8e-07 31.2 7.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain VCBS PF13517.6 EXF73505.1 - 9.1e-33 112.7 37.3 8.6e-12 45.5 2.7 8.3 5 1 3 8 8 8 7 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella TcdB_toxin_midN PF12256.8 EXF73505.1 - 4.9e-10 39.1 6.5 0.07 12.5 0.0 6.6 4 2 1 6 6 6 3 Insecticide toxin TcdB middle/N-terminal region Lipase_GDSL_2 PF13472.6 EXF73505.1 - 1.2e-09 38.8 0.4 2.9e-09 37.6 0.4 1.7 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Dockerin_1 PF00404.18 EXF73505.1 - 0.00019 21.5 6.6 2.3 8.5 0.1 4.8 4 0 0 4 4 4 2 Dockerin type I domain PliI PF16743.5 EXF73505.1 - 0.002 17.9 1.1 0.27 11.0 0.0 3.9 3 1 1 4 4 4 1 Periplasmic lysozyme inhibitor of I-type lysozyme FG-GAP PF01839.23 EXF73505.1 - 0.0077 16.3 0.2 0.0077 16.3 0.2 6.0 7 0 0 7 7 7 3 FG-GAP repeat Lipase_GDSL PF00657.22 EXF73505.1 - 0.019 15.0 0.0 0.041 13.9 0.0 1.6 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase CFEM PF05730.11 EXF73508.1 - 6.6e-15 55.0 10.8 9.6e-15 54.4 10.8 1.3 1 0 0 1 1 1 1 CFEM domain DUF1418 PF07214.12 EXF73508.1 - 0.15 11.9 4.0 0.072 13.0 1.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1418) UPF0182 PF03699.13 EXF73508.1 - 0.39 8.8 5.7 0.66 8.0 5.7 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0182) NAD_binding_10 PF13460.6 EXF73510.1 - 9e-07 29.0 0.0 1.1e-06 28.6 0.0 1.0 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EXF73510.1 - 7.6e-06 25.7 0.0 7.9e-06 25.6 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family DUF5387 PF17361.2 EXF73510.1 - 0.11 12.1 0.0 0.13 11.9 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5387) BB_PF PF18063.1 EXF73511.1 - 0.14 11.7 0.0 6 6.4 0.0 2.1 2 0 0 2 2 2 0 Beta barrel Pore-forming domain zf-C2H2_jaz PF12171.8 EXF73512.1 - 1.4e-17 63.5 15.1 2.9e-07 30.6 1.9 5.2 5 0 0 5 5 5 3 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EXF73512.1 - 1.5e-16 60.1 15.6 3.1e-06 27.4 0.4 5.0 5 0 0 5 5 5 3 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 EXF73512.1 - 2.7e-16 58.9 23.9 0.0073 17.1 0.3 6.6 6 0 0 6 6 6 6 C2H2-type zinc finger zf-C2H2_2 PF12756.7 EXF73512.1 - 1.8e-10 41.1 21.9 0.0018 18.6 0.6 4.9 2 2 2 4 4 4 3 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.26 EXF73512.1 - 9.1e-10 38.4 30.9 0.023 15.1 0.7 6.8 6 0 0 6 6 6 5 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 EXF73512.1 - 4.6e-05 23.3 21.3 0.0014 18.6 0.7 5.6 6 0 0 6 6 6 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EXF73512.1 - 7.2e-05 23.0 26.1 0.079 13.4 0.1 6.6 6 0 0 6 6 6 3 Zinc-finger double domain zf_ZIC PF18366.1 EXF73512.1 - 0.0015 18.6 7.6 4.8 7.4 0.3 4.7 4 0 0 4 4 4 1 Zic proteins zinc finger domain zf-RRPl_C4 PF17026.5 EXF73512.1 - 0.002 18.2 3.2 0.002 18.2 3.2 2.8 2 1 1 3 3 3 1 Putative ribonucleoprotein zinc-finger pf C4 type AKAP95 PF04988.12 EXF73512.1 - 0.021 15.1 8.5 1.5 9.0 0.5 3.6 3 1 1 4 4 4 0 A-kinase anchoring protein 95 (AKAP95) zf-Di19 PF05605.12 EXF73512.1 - 0.023 15.0 0.2 0.023 15.0 0.2 4.6 3 2 0 4 4 4 0 Drought induced 19 protein (Di19), zinc-binding HOCHOB PF17943.1 EXF73512.1 - 0.046 14.4 1.4 0.21 12.3 0.9 2.0 2 0 0 2 2 2 0 Homeobox-cysteine loop-homeobox Rad50_zn_hook PF04423.14 EXF73512.1 - 0.099 12.5 5.3 2.9 7.8 0.0 3.7 3 1 1 4 4 4 0 Rad50 zinc hook motif zf-C2H2_11 PF16622.5 EXF73512.1 - 0.23 11.3 14.3 0.4 10.5 0.2 5.4 6 0 0 6 6 6 0 zinc-finger C2H2-type Zn-ribbon_8 PF09723.10 EXF73512.1 - 3.8 7.7 21.6 18 5.5 1.1 5.4 4 1 1 5 5 5 0 Zinc ribbon domain zf-C2HC_2 PF13913.6 EXF73512.1 - 4.2 7.4 15.6 6.7 6.7 0.0 4.9 5 0 0 5 5 5 0 zinc-finger of a C2HC-type HypA PF01155.19 EXF73512.1 - 7 6.7 10.9 2.6 8.1 2.6 3.3 2 2 1 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA SET PF00856.28 EXF73513.1 - 9e-13 49.0 0.0 1.3e-11 45.2 0.0 2.5 1 1 0 1 1 1 1 SET domain TPR_11 PF13414.6 EXF73513.1 - 0.00039 20.0 3.2 0.53 10.0 0.4 3.7 4 0 0 4 4 4 2 TPR repeat SAF PF08666.12 EXF73513.1 - 0.029 15.0 0.1 22 5.8 0.0 3.0 3 0 0 3 3 3 0 SAF domain TPR_2 PF07719.17 EXF73513.1 - 0.32 11.2 0.1 0.32 11.2 0.1 4.7 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_1 PF00515.28 EXF73513.1 - 1.7 8.6 7.3 4.4 7.3 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 EXF73513.1 - 5.7 7.5 7.9 17 6.0 0.2 3.2 4 0 0 4 4 4 0 Tetratricopeptide repeat Alk_phosphatase PF00245.20 EXF73514.1 - 1e-75 255.3 0.0 1.4e-75 254.8 0.0 1.2 1 0 0 1 1 1 1 Alkaline phosphatase Sulfatase PF00884.23 EXF73514.1 - 1.5e-06 27.9 0.0 2.7e-06 27.0 0.0 1.5 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 EXF73514.1 - 0.00015 21.5 0.0 0.00025 20.7 0.0 1.3 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase DUF229 PF02995.17 EXF73514.1 - 0.0057 15.3 0.1 0.0082 14.8 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF229) Metalloenzyme PF01676.18 EXF73514.1 - 0.02 14.2 0.6 0.057 12.8 0.1 1.9 3 0 0 3 3 3 0 Metalloenzyme superfamily Fungal_trans_2 PF11951.8 EXF73515.1 - 1.1e-32 113.3 15.7 2.9e-21 75.7 9.4 2.1 1 1 1 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF73515.1 - 0.025 14.7 3.9 0.053 13.6 3.9 1.5 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF3147 PF11345.8 EXF73516.1 - 0.022 15.1 1.2 0.26 11.7 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3147) Phage_holin_5_2 PF16079.5 EXF73516.1 - 9.4 6.7 9.4 10 6.5 0.5 3.7 2 2 2 4 4 4 0 Phage holin family Hol44, in holin superfamily V MFS_1 PF07690.16 EXF73518.1 - 8.2e-35 120.4 26.0 8.5e-35 120.3 25.3 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily NADH-u_ox-rdase PF10785.9 EXF73518.1 - 4.9 7.9 6.3 1.2 9.8 0.9 2.8 3 0 0 3 3 3 0 NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit Chromo PF00385.24 EXF73520.1 - 5.8e-05 22.9 6.2 0.015 15.2 0.3 2.6 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain AT_hook PF02178.19 EXF73520.1 - 3.3 7.9 33.3 0.11 12.4 1.5 4.5 4 0 0 4 4 4 0 AT hook motif Ank_2 PF12796.7 EXF73521.1 - 1.1e-35 122.0 2.6 2.3e-10 40.9 0.4 5.9 2 2 5 7 7 7 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EXF73521.1 - 7.9e-25 86.9 2.8 5.3e-06 26.9 0.2 7.1 3 1 5 8 8 8 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EXF73521.1 - 2.6e-19 67.3 5.7 0.018 15.5 0.2 9.7 10 0 0 10 10 8 4 Ankyrin repeat Ank_5 PF13857.6 EXF73521.1 - 9.2e-14 51.3 8.8 0.05 14.0 0.0 7.0 3 3 4 7 7 7 6 Ankyrin repeats (many copies) Ank PF00023.30 EXF73521.1 - 2.8e-12 46.5 8.9 0.014 15.8 0.2 6.7 6 1 0 6 6 6 4 Ankyrin repeat Helo_like_N PF17111.5 EXF73521.1 - 4.2e-06 26.3 0.0 9e-06 25.2 0.0 1.5 1 0 0 1 1 1 1 Fungal N-terminal domain of STAND proteins NACHT PF05729.12 EXF73521.1 - 9.8e-06 25.6 0.0 3.2e-05 23.9 0.0 1.9 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 EXF73521.1 - 3.8e-05 24.1 0.1 0.00026 21.4 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EXF73521.1 - 7.3e-05 23.1 0.0 0.00016 21.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain KAP_NTPase PF07693.14 EXF73521.1 - 0.023 13.9 0.2 0.07 12.4 0.1 1.7 1 1 0 2 2 2 0 KAP family P-loop domain AAA PF00004.29 EXF73521.1 - 0.062 13.7 0.0 0.28 11.6 0.0 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) FtsK_SpoIIIE PF01580.18 EXF73521.1 - 0.12 11.7 0.5 3.1 7.1 0.0 3.0 3 0 0 3 3 3 0 FtsK/SpoIIIE family RNA_helicase PF00910.22 EXF73521.1 - 0.2 12.1 0.0 0.69 10.3 0.0 2.0 1 0 0 1 1 1 0 RNA helicase FliT PF05400.13 EXF73521.1 - 0.33 11.8 0.0 0.33 11.8 0.0 3.0 3 0 0 3 3 2 0 Flagellar protein FliT EMC3_TMCO1 PF01956.16 EXF73522.1 - 1.5 8.5 3.0 2.9 7.6 3.0 1.4 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like DHR10 PF18595.1 EXF73522.1 - 1.6 8.8 11.3 3.4 7.7 11.3 1.5 1 0 0 1 1 1 0 Designed helical repeat protein 10 domain HicA_toxin PF07927.12 EXF73524.1 - 0.059 13.4 0.0 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 HicA toxin of bacterial toxin-antitoxin, DUF3299 PF11736.8 EXF73524.1 - 1.3 9.1 0.0 1.3 9.1 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3299) COesterase PF00135.28 EXF73525.1 - 3e-79 267.3 0.0 3.1e-68 230.9 0.0 2.0 1 1 1 2 2 2 2 Carboxylesterase family Abhydrolase_3 PF07859.13 EXF73525.1 - 0.0035 17.2 5.2 0.048 13.5 5.2 2.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EXF73525.1 - 0.068 13.8 0.9 0.13 12.8 0.1 1.8 2 0 0 2 2 2 0 Alpha/beta hydrolase family Zn_clus PF00172.18 EXF73526.1 - 3.3e-10 39.9 7.4 6.4e-10 39.0 7.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Sugar_tr PF00083.24 EXF73527.1 - 1.1e-88 298.2 19.7 1.2e-88 297.9 19.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF73527.1 - 1.6e-34 119.4 34.3 3e-31 108.6 24.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Fungal_trans PF04082.18 EXF73528.1 - 1e-22 80.5 0.4 1.4e-22 80.0 0.4 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF73528.1 - 5.9e-08 32.7 9.8 9.2e-08 32.1 9.8 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FAA_hydrolase PF01557.18 EXF73529.1 - 2.3e-63 213.8 0.0 2.8e-63 213.5 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family Epimerase PF01370.21 EXF73532.1 - 3.8e-17 62.6 0.1 5.5e-17 62.0 0.1 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EXF73532.1 - 8.3e-11 42.1 6.0 1.1e-08 35.2 2.3 2.9 1 1 1 2 2 2 2 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 EXF73532.1 - 2.7e-10 40.1 0.0 4.2e-10 39.5 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 EXF73532.1 - 1.8e-08 33.7 0.0 2.6e-08 33.2 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 EXF73532.1 - 2.1e-06 27.1 0.8 1.4e-05 24.4 0.8 2.0 1 1 0 1 1 1 1 Male sterility protein NmrA PF05368.13 EXF73532.1 - 1.2e-05 25.1 0.2 2.8e-05 23.8 0.2 1.7 1 0 0 1 1 1 1 NmrA-like family Polysacc_synt_2 PF02719.15 EXF73532.1 - 0.00056 19.1 0.0 0.00083 18.6 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein MoCF_biosynth PF00994.24 EXF73532.1 - 0.022 14.4 0.0 0.084 12.5 0.0 2.0 2 0 0 2 2 2 0 Probable molybdopterin binding domain Glyco_trans_4_4 PF13579.6 EXF73532.1 - 0.08 13.4 4.7 0.76 10.2 0.4 2.5 1 1 1 2 2 2 0 Glycosyl transferase 4-like domain adh_short PF00106.25 EXF73532.1 - 0.12 11.9 1.1 4.3 6.7 0.0 2.6 2 1 0 2 2 2 0 short chain dehydrogenase HATPase_c PF02518.26 EXF73533.1 - 4.6e-21 75.4 0.1 1.1e-20 74.2 0.1 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EXF73533.1 - 3.8e-20 72.1 0.0 1.6e-19 70.1 0.0 2.2 2 0 0 2 2 2 1 Response regulator receiver domain HisKA PF00512.25 EXF73533.1 - 5.6e-10 39.1 0.1 1.5e-09 37.7 0.1 1.7 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain GAF PF01590.26 EXF73533.1 - 2.6e-05 24.9 0.1 0.0011 19.6 0.0 2.9 2 0 0 2 2 2 1 GAF domain Hamartin PF04388.12 EXF73534.1 - 0.34 9.5 6.8 0.49 9.0 6.8 1.2 1 0 0 1 1 1 0 Hamartin protein DUF908 PF06012.12 EXF73534.1 - 2.6 7.4 5.6 4.2 6.7 5.6 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) PolC_DP2 PF03833.13 EXF73536.1 - 0.00034 18.6 3.4 0.00039 18.5 3.4 1.0 1 0 0 1 1 1 1 DNA polymerase II large subunit DP2 zf-MYND PF01753.18 EXF73536.1 - 0.0012 18.9 9.4 0.0012 18.9 9.4 2.1 2 0 0 2 2 2 1 MYND finger zinc_ribbon_11 PF11682.8 EXF73536.1 - 0.0019 18.2 1.3 0.0028 17.6 1.3 1.3 1 0 0 1 1 1 1 Probable zinc-ribbon zf-HIT PF04438.16 EXF73536.1 - 0.026 14.4 8.6 0.73 9.8 5.7 2.8 2 1 0 2 2 2 0 HIT zinc finger GATA PF00320.27 EXF73537.1 - 2.6e-14 52.5 5.9 4.6e-14 51.7 5.9 1.4 1 0 0 1 1 1 1 GATA zinc finger Nudix_N_2 PF14803.6 EXF73537.1 - 1.5 8.8 5.7 6.6 6.7 5.7 2.0 1 1 0 1 1 1 0 Nudix N-terminal AA_permease_2 PF13520.6 EXF73538.1 - 1.7e-48 165.5 39.8 2.2e-48 165.1 39.8 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EXF73538.1 - 7.6e-17 61.1 37.3 1.2e-16 60.4 25.9 2.3 2 0 0 2 2 2 2 Amino acid permease GAF PF01590.26 EXF73538.1 - 5.4e-11 43.2 0.0 1.3e-10 42.0 0.0 1.6 1 0 0 1 1 1 1 GAF domain PHY PF00360.20 EXF73538.1 - 0.024 14.0 0.0 0.046 13.0 0.0 1.4 1 0 0 1 1 1 0 Phytochrome region Aldo_ket_red PF00248.21 EXF73539.1 - 1e-43 149.6 0.0 2.2e-43 148.5 0.0 1.5 1 1 0 1 1 1 1 Aldo/keto reductase family Glyco_hydro_10 PF00331.20 EXF73540.1 - 2.1e-87 293.3 0.2 2.5e-87 293.0 0.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 10 HET PF06985.11 EXF73541.1 - 8.9e-29 100.7 0.0 1.7e-28 99.8 0.0 1.5 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Amidohydro_2 PF04909.14 EXF73542.1 - 3.9e-24 86.0 0.0 5e-24 85.6 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase Abhydrolase_3 PF07859.13 EXF73543.1 - 1.7e-20 73.8 0.0 2.6e-20 73.2 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 EXF73543.1 - 2.4e-15 56.3 0.0 3.4e-15 55.8 0.0 1.1 1 0 0 1 1 1 1 Steryl acetyl hydrolase adh_short PF00106.25 EXF73544.1 - 1.2e-35 122.8 0.0 1.7e-35 122.2 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF73544.1 - 1.2e-17 64.3 0.0 1.9e-17 63.6 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF73544.1 - 6.3e-07 29.5 0.4 6e-06 26.3 0.0 2.4 2 1 0 2 2 2 1 KR domain 3Beta_HSD PF01073.19 EXF73544.1 - 0.00091 18.3 0.0 0.0013 17.8 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EXF73544.1 - 0.00092 18.7 0.0 0.0014 18.2 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF1776 PF08643.10 EXF73544.1 - 0.0056 16.1 0.0 0.0093 15.4 0.0 1.3 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) TA_inhibitor PF17574.2 EXF73544.1 - 0.095 12.7 0.0 1.3 9.1 0.0 2.4 2 0 0 2 2 2 0 Inhibitor of toxin/antitoxin system (Gp4.5) K_oxygenase PF13434.6 EXF73545.1 - 3.7e-11 42.8 0.7 8.2e-10 38.3 0.1 2.5 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) FMO-like PF00743.19 EXF73545.1 - 9.3e-11 40.8 0.3 1.8e-10 39.9 0.3 1.4 1 1 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EXF73545.1 - 2.6e-06 26.9 0.0 1.1e-05 24.9 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EXF73545.1 - 8.8e-06 25.9 0.0 2.1e-05 24.7 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EXF73545.1 - 6.7e-05 22.3 0.0 0.00034 19.9 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Shikimate_DH PF01488.20 EXF73545.1 - 0.16 12.0 0.0 0.38 10.8 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Polyketide_cyc2 PF10604.9 EXF73546.1 - 1.5e-07 31.7 0.2 1.7e-07 31.6 0.2 1.1 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport DUF4520 PF15016.6 EXF73546.1 - 0.021 14.9 0.0 0.044 13.9 0.0 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4520) FAD_binding_3 PF01494.19 EXF73547.1 - 4e-79 266.4 0.0 5.1e-79 266.1 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Phe_hydrox_dim PF07976.12 EXF73547.1 - 2e-40 138.6 0.0 2.1e-39 135.2 0.0 2.2 2 0 0 2 2 2 1 Phenol hydroxylase, C-terminal dimerisation domain FAD_binding_2 PF00890.24 EXF73547.1 - 0.00026 20.2 0.1 0.001 18.2 0.0 1.9 2 0 0 2 2 2 1 FAD binding domain Thi4 PF01946.17 EXF73547.1 - 0.0017 17.6 0.0 0.0036 16.6 0.0 1.5 1 0 0 1 1 1 1 Thi4 family SE PF08491.10 EXF73547.1 - 0.0028 16.8 0.0 0.0086 15.2 0.0 1.8 1 1 0 1 1 1 1 Squalene epoxidase FAD_oxidored PF12831.7 EXF73547.1 - 0.0058 16.0 0.1 0.012 15.0 0.1 1.6 1 1 0 1 1 1 1 FAD dependent oxidoreductase DAO PF01266.24 EXF73547.1 - 0.0098 15.5 0.6 0.048 13.2 0.1 2.0 1 1 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EXF73547.1 - 0.033 13.4 0.1 0.075 12.2 0.1 1.6 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EXF73547.1 - 0.067 13.4 0.1 0.18 12.1 0.1 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain ApbA PF02558.16 EXF73547.1 - 0.18 11.5 0.3 0.5 10.0 0.1 1.9 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA SSF PF00474.17 EXF73548.1 - 6e-20 71.5 27.0 6e-20 71.5 27.0 1.7 2 0 0 2 2 2 1 Sodium:solute symporter family Pox_A14 PF05767.12 EXF73548.1 - 2.4 8.4 5.9 2.7 8.2 0.2 3.3 3 0 0 3 3 3 0 Poxvirus virion envelope protein A14 DUF2436 PF10365.9 EXF73550.1 - 0.011 15.4 0.1 0.021 14.6 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2436) PhyH PF05721.13 EXF73551.1 - 1.3e-19 71.3 0.0 1.7e-19 70.9 0.0 1.2 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) 2OG-FeII_Oxy_3 PF13640.6 EXF73551.1 - 0.0051 17.7 0.0 0.0097 16.8 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_5 PF13759.6 EXF73551.1 - 0.11 13.0 0.0 0.32 11.4 0.0 1.8 1 0 0 1 1 1 0 Putative 2OG-Fe(II) oxygenase Asp_Arg_Hydrox PF05118.15 EXF73551.1 - 0.19 11.6 0.0 0.39 10.5 0.0 1.5 1 0 0 1 1 1 0 Aspartyl/Asparaginyl beta-hydroxylase Transp_cyt_pur PF02133.15 EXF73552.1 - 3.6e-35 121.6 30.4 3.1e-34 118.5 30.4 2.0 1 1 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin PIRT PF15099.6 EXF73552.1 - 0.15 11.6 1.2 0.96 9.0 0.2 2.5 2 0 0 2 2 2 0 Phosphoinositide-interacting protein family Tannase PF07519.11 EXF73553.1 - 2.4e-108 363.1 0.1 2.8e-108 362.8 0.1 1.0 1 0 0 1 1 1 1 Tannase and feruloyl esterase Peptidase_S9 PF00326.21 EXF73553.1 - 0.00012 21.6 0.3 0.27 10.7 0.0 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 EXF73553.1 - 0.0095 15.6 0.1 0.043 13.5 0.0 1.9 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EXF73553.1 - 0.15 11.3 0.0 0.29 10.4 0.0 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 FAD_binding_3 PF01494.19 EXF73554.1 - 7.2e-08 32.1 0.0 0.0054 16.0 0.0 2.5 2 1 0 2 2 2 2 FAD binding domain Pyr_redox_2 PF07992.14 EXF73554.1 - 0.00071 18.9 0.2 0.0016 17.7 0.2 1.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EXF73554.1 - 0.0085 15.4 0.1 0.016 14.5 0.1 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EXF73554.1 - 0.052 13.8 0.1 0.19 12.0 0.1 2.0 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 EXF73554.1 - 0.084 11.6 0.2 0.17 10.6 0.2 1.5 1 0 0 1 1 1 0 HI0933-like protein GFO_IDH_MocA PF01408.22 EXF73555.1 - 1.3e-14 55.0 0.0 2.3e-14 54.2 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA PF01408.22 EXF73556.1 - 2.8e-20 73.3 0.1 5.2e-20 72.5 0.1 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 EXF73556.1 - 0.00031 20.7 0.0 0.00055 19.9 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain KRE1 PF17056.5 EXF73556.1 - 0.14 11.9 0.0 0.29 10.9 0.0 1.5 1 0 0 1 1 1 0 Killer toxin-resistance protein 1 FAD_binding_4 PF01565.23 EXF73557.1 - 4e-09 36.3 1.5 4e-09 36.3 1.5 1.5 2 0 0 2 2 2 1 FAD binding domain FAD_binding_3 PF01494.19 EXF73558.1 - 5e-12 45.7 0.1 1.9e-10 40.5 0.1 2.7 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.24 EXF73558.1 - 5e-08 32.9 0.4 0.0011 18.7 0.1 2.4 2 1 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EXF73558.1 - 6e-08 32.3 0.0 0.0011 18.3 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EXF73558.1 - 2e-07 31.1 0.0 6.4e-07 29.5 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EXF73558.1 - 3.8e-05 23.0 0.2 6.9e-05 22.1 0.2 1.4 1 0 0 1 1 1 1 FAD binding domain Lycopene_cycl PF05834.12 EXF73558.1 - 0.00011 21.4 0.0 0.01 15.0 0.0 2.7 2 1 0 2 2 2 1 Lycopene cyclase protein HI0933_like PF03486.14 EXF73558.1 - 0.00021 20.1 0.1 0.0034 16.2 0.1 2.0 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox_3 PF13738.6 EXF73558.1 - 0.00046 19.5 0.0 0.0042 16.4 0.0 2.0 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EXF73558.1 - 0.00092 18.4 0.1 0.053 12.6 0.0 2.1 2 0 0 2 2 2 1 Glucose inhibited division protein A Pyr_redox PF00070.27 EXF73558.1 - 0.0019 18.7 0.1 0.034 14.7 0.1 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EXF73558.1 - 0.013 14.9 0.1 0.02 14.3 0.1 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.21 EXF73558.1 - 0.043 13.1 0.0 0.072 12.4 0.0 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Presenilin PF01080.17 EXF73559.1 - 1.4 7.7 4.4 1.6 7.4 4.4 1.3 1 0 0 1 1 1 0 Presenilin SspK PF08176.12 EXF73560.1 - 0.027 14.7 0.7 9.6 6.6 0.1 2.5 2 0 0 2 2 2 0 Small acid-soluble spore protein K family Methyltransf_22 PF13383.6 EXF73561.1 - 2.3e-14 53.6 0.2 3.2e-14 53.1 0.2 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_21 PF05050.12 EXF73561.1 - 5.5e-09 36.3 0.0 7.6e-09 35.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase FkbM domain MFS_1 PF07690.16 EXF73562.1 - 2.4e-32 112.3 52.5 5.3e-31 107.8 52.3 2.7 2 1 0 2 2 2 1 Major Facilitator Superfamily Aldedh PF00171.22 EXF73564.1 - 6.8e-154 512.8 0.0 7.7e-154 512.6 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family p450 PF00067.22 EXF73565.1 - 6.2e-39 134.0 0.0 8.3e-39 133.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 PV_NSP1 PF12433.8 EXF73565.1 - 0.023 15.0 0.0 0.051 13.9 0.0 1.5 1 0 0 1 1 1 0 Parvovirus non-structural protein 1 PTR2 PF00854.21 EXF73567.1 - 1.9e-55 188.3 3.1 1.9e-55 188.3 3.1 1.9 1 1 1 2 2 2 1 POT family CBM_21 PF03370.13 EXF73569.1 - 2.4e-35 121.1 0.8 3.9e-35 120.4 0.8 1.3 1 0 0 1 1 1 1 Carbohydrate/starch-binding module (family 21) CBM53 PF16760.5 EXF73569.1 - 1.2e-10 41.8 1.5 2.7e-10 40.7 1.5 1.5 1 0 0 1 1 1 1 Starch/carbohydrate-binding module (family 53) AAA PF00004.29 EXF73573.1 - 2.2e-17 63.7 0.9 7.1e-17 62.1 0.0 2.4 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EXF73573.1 - 0.0018 18.7 3.2 0.0022 18.4 0.3 2.7 2 1 0 2 2 2 1 AAA ATPase domain ATPase PF06745.13 EXF73573.1 - 0.0054 16.1 0.4 0.018 14.4 0.4 1.9 1 0 0 1 1 1 1 KaiC Metal_CEHH PF14455.6 EXF73573.1 - 0.0066 16.1 1.0 1.4 8.5 0.5 2.5 2 0 0 2 2 2 2 Predicted metal binding domain AAA_22 PF13401.6 EXF73573.1 - 0.0091 16.3 8.7 0.02 15.2 2.0 3.9 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EXF73573.1 - 0.038 13.7 0.0 0.14 11.9 0.0 2.0 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 EXF73573.1 - 0.056 13.4 0.0 0.16 12.0 0.0 1.8 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 EXF73573.1 - 0.074 12.8 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_33 PF13671.6 EXF73573.1 - 0.11 12.7 0.0 0.42 10.8 0.0 2.1 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 EXF73573.1 - 0.14 11.5 0.0 0.34 10.3 0.0 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_24 PF13479.6 EXF73573.1 - 0.18 11.5 0.8 1 9.0 0.0 2.5 3 0 0 3 3 3 0 AAA domain DUF2075 PF09848.9 EXF73573.1 - 0.29 10.3 4.8 2.8 7.1 0.0 2.7 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2075) DHHC PF01529.20 EXF73574.1 - 4.6e-33 114.2 12.8 4.6e-33 114.2 12.8 2.1 2 1 0 2 2 2 1 DHHC palmitoyltransferase Ank_2 PF12796.7 EXF73574.1 - 1e-28 99.7 0.0 1.6e-13 51.0 0.0 3.1 2 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EXF73574.1 - 2.5e-24 85.3 2.9 4.6e-06 27.1 0.1 5.0 3 1 3 6 6 6 5 Ankyrin repeats (many copies) Ank PF00023.30 EXF73574.1 - 5.7e-23 80.3 0.5 5.9e-05 23.3 0.0 5.6 5 0 0 5 5 5 4 Ankyrin repeat Ank_3 PF13606.6 EXF73574.1 - 1.2e-22 77.5 0.5 5.9e-07 29.3 0.0 6.1 6 0 0 6 6 6 4 Ankyrin repeat Ank_5 PF13857.6 EXF73574.1 - 3.2e-22 78.3 0.2 2.9e-06 27.4 0.0 5.7 3 2 2 5 5 5 4 Ankyrin repeats (many copies) Colicin_V PF02674.16 EXF73574.1 - 0.21 11.6 6.4 1.2 9.1 6.1 2.3 1 1 0 1 1 1 0 Colicin V production protein SRPRB PF09439.10 EXF73575.1 - 5.4e-25 87.9 0.0 1.7e-24 86.3 0.0 1.8 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 EXF73575.1 - 0.0002 21.4 0.0 0.00032 20.8 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 EXF73575.1 - 0.00083 19.8 0.3 0.0014 19.1 0.3 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EXF73575.1 - 0.00085 19.6 0.0 0.0021 18.4 0.0 1.7 1 1 0 1 1 1 1 AAA domain Arf PF00025.21 EXF73575.1 - 0.0033 16.9 0.0 2.2 7.7 0.0 2.6 2 1 0 2 2 2 2 ADP-ribosylation factor family Septin PF00735.18 EXF73575.1 - 0.0041 16.5 0.0 0.0062 15.8 0.0 1.2 1 0 0 1 1 1 1 Septin Roc PF08477.13 EXF73575.1 - 0.028 14.6 0.0 0.079 13.2 0.0 1.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase TniB PF05621.11 EXF73575.1 - 0.028 13.8 0.0 0.045 13.1 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein AAA PF00004.29 EXF73575.1 - 0.082 13.3 0.0 4.3 7.8 0.0 2.4 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.27 EXF73575.1 - 0.084 13.4 0.0 0.15 12.6 0.0 1.3 1 0 0 1 1 1 0 ABC transporter RsgA_GTPase PF03193.16 EXF73575.1 - 0.087 12.7 0.4 0.29 11.0 0.3 1.9 2 1 0 2 2 2 0 RsgA GTPase AAA_30 PF13604.6 EXF73575.1 - 0.18 11.5 0.6 0.32 10.7 0.2 1.5 1 1 0 1 1 1 0 AAA domain cobW PF02492.19 EXF73575.1 - 0.22 11.1 0.0 3.8 7.1 0.0 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain PALP PF00291.25 EXF73576.1 - 2.4e-66 224.1 0.1 3.1e-66 223.8 0.1 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme CBS PF00571.28 EXF73576.1 - 2.8e-12 46.9 0.0 4.1e-09 36.7 0.0 3.0 2 0 0 2 2 2 2 CBS domain Pyr_redox_2 PF07992.14 EXF73577.1 - 4.9e-33 114.6 0.0 6.3e-33 114.3 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EXF73577.1 - 9.5e-13 48.5 0.1 9e-10 39.0 0.1 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EXF73577.1 - 1.5e-05 24.8 2.6 1.8 8.0 0.1 4.0 4 0 0 4 4 4 2 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EXF73577.1 - 6.7e-05 22.3 0.0 0.00015 21.1 0.0 1.8 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EXF73577.1 - 0.0014 17.5 0.1 1.2 7.9 0.0 2.5 2 0 0 2 2 2 2 Tryptophan halogenase GIDA PF01134.22 EXF73577.1 - 0.026 13.6 3.5 3.4 6.7 0.0 2.7 3 0 0 3 3 3 0 Glucose inhibited division protein A K_oxygenase PF13434.6 EXF73577.1 - 0.029 13.5 0.0 0.053 12.6 0.0 1.4 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) Thi4 PF01946.17 EXF73577.1 - 0.03 13.6 1.0 8.4 5.6 0.0 3.0 3 0 0 3 3 3 0 Thi4 family NAD_binding_9 PF13454.6 EXF73577.1 - 0.089 12.8 0.5 16 5.4 0.1 3.6 4 0 0 4 4 4 0 FAD-NAD(P)-binding FAD_binding_3 PF01494.19 EXF73577.1 - 0.37 10.0 1.3 0.44 9.7 0.1 1.9 2 0 0 2 2 2 0 FAD binding domain Lycopene_cycl PF05834.12 EXF73577.1 - 0.44 9.5 3.5 1.8 7.5 0.1 3.1 3 1 1 4 4 4 0 Lycopene cyclase protein FAD_oxidored PF12831.7 EXF73577.1 - 0.54 9.5 6.4 1.1 8.5 0.0 2.5 3 0 0 3 3 3 0 FAD dependent oxidoreductase Dodecin PF07311.12 EXF73578.1 - 0.2 11.9 0.4 0.47 10.7 0.4 1.6 1 0 0 1 1 1 0 Dodecin TetR_C_36 PF18598.1 EXF73579.1 - 0.13 12.2 0.1 0.26 11.3 0.1 1.4 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain QslA_E PF18226.1 EXF73580.1 - 0.04 13.8 0.2 0.086 12.8 0.2 1.5 1 0 0 1 1 1 0 LasR-specific antiactivator QslA chain E AAA PF00004.29 EXF73582.1 - 5.1e-17 62.5 0.0 1.1e-16 61.5 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EXF73582.1 - 0.00029 21.3 0.0 0.001 19.4 0.0 2.0 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EXF73582.1 - 0.013 15.7 0.0 0.06 13.6 0.0 2.0 1 1 1 2 2 2 0 AAA domain RuvB_N PF05496.12 EXF73582.1 - 0.014 15.1 0.0 0.026 14.3 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 EXF73582.1 - 0.021 14.8 0.0 0.061 13.3 0.0 1.8 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) FAD_binding_4 PF01565.23 EXF73583.1 - 9.4e-21 74.0 0.1 1.5e-20 73.4 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain Pro-kuma_activ PF09286.11 EXF73584.1 - 2.3e-28 99.3 0.1 1e-27 97.2 0.0 2.0 2 0 0 2 2 2 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 EXF73584.1 - 0.00068 19.0 0.1 0.0014 17.9 0.1 1.5 1 0 0 1 1 1 1 Subtilase family Med13_N PF11597.8 EXF73584.1 - 0.088 12.2 0.2 0.15 11.5 0.2 1.2 1 0 0 1 1 1 0 Mediator complex subunit 13 N-terminal DUF2985 PF11204.8 EXF73586.1 - 9.6e-38 128.2 0.6 3e-37 126.6 0.6 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF2985) ICMT PF04140.14 EXF73586.1 - 2.3e-07 31.1 0.1 1.2e-06 28.8 0.0 2.1 2 0 0 2 2 2 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 EXF73586.1 - 1.3e-06 28.8 1.5 1e-05 25.9 0.0 2.9 3 0 0 3 3 3 1 Phospholipid methyltransferase Sugar_tr PF00083.24 EXF73587.1 - 1.2e-61 209.0 33.7 1.5e-61 208.7 33.7 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF73587.1 - 3.8e-21 75.4 31.2 6.9e-21 74.6 31.1 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily Glyco_hyd_65N_2 PF14498.6 EXF73588.1 - 2.2e-60 204.4 0.0 2.9e-60 204.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, N-terminal domain NUDE_C PF04880.13 EXF73590.1 - 1.2e-38 133.4 18.7 1.2e-38 133.4 18.7 5.0 2 2 2 4 4 1 1 NUDE protein, C-terminal conserved region ZapB PF06005.12 EXF73590.1 - 0.00077 19.8 9.0 0.00077 19.8 9.0 4.8 2 1 3 5 5 5 1 Cell division protein ZapB Alanine_zipper PF11839.8 EXF73590.1 - 0.0043 17.4 7.3 0.0043 17.4 7.3 2.5 3 0 0 3 3 2 1 Alanine-zipper, major outer membrane lipoprotein PSII_Pbs27 PF13326.6 EXF73590.1 - 0.0083 16.5 4.5 0.0083 16.5 4.5 1.8 2 0 0 2 2 2 1 Photosystem II Pbs27 Chibby PF14645.6 EXF73590.1 - 0.091 13.2 16.1 0.3 11.5 8.0 2.6 1 1 1 2 2 2 0 Chibby family FPP PF05911.11 EXF73590.1 - 0.12 10.5 34.9 0.0077 14.5 18.9 2.1 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil DUF3584 PF12128.8 EXF73590.1 - 0.15 9.5 27.0 0.22 9.0 27.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) CENP-F_leu_zip PF10473.9 EXF73590.1 - 0.16 12.0 39.9 19 5.2 32.9 3.9 2 1 2 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 YjbH PF06082.11 EXF73590.1 - 0.28 10.0 8.7 0.43 9.3 8.7 1.2 1 0 0 1 1 1 0 Exopolysaccharide biosynthesis protein YbjH Fez1 PF06818.15 EXF73590.1 - 0.28 11.6 32.6 0.096 13.1 15.1 2.8 2 1 1 3 3 3 0 Fez1 AKNA PF12443.8 EXF73590.1 - 0.62 10.7 9.2 6.2 7.6 4.0 3.3 3 0 0 3 3 3 0 AT-hook-containing transcription factor ERM PF00769.19 EXF73590.1 - 0.77 9.5 39.3 0.21 11.3 20.5 2.3 1 1 1 2 2 2 0 Ezrin/radixin/moesin family IFT57 PF10498.9 EXF73590.1 - 0.92 8.4 27.9 0.077 11.9 13.3 2.1 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 Tropomyosin_1 PF12718.7 EXF73590.1 - 0.96 9.6 41.6 25 5.0 26.5 4.4 2 1 1 3 3 3 0 Tropomyosin like Tho2 PF11262.8 EXF73590.1 - 1.7 7.8 21.4 0.29 10.3 3.7 2.1 2 0 0 2 2 2 0 Transcription factor/nuclear export subunit protein 2 Filament PF00038.21 EXF73590.1 - 1.8 8.1 36.2 1.6 8.3 10.9 2.4 2 1 1 3 3 3 0 Intermediate filament protein Prefoldin_2 PF01920.20 EXF73590.1 - 2.9 7.9 35.8 0.54 10.2 11.1 5.2 2 1 3 5 5 4 0 Prefoldin subunit Atg14 PF10186.9 EXF73590.1 - 7.1 5.6 30.8 3.2 6.7 14.2 3.0 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 ATG16 PF08614.11 EXF73590.1 - 7.6 6.7 42.1 0.023 14.9 19.0 3.2 2 2 2 4 4 4 0 Autophagy protein 16 (ATG16) Glyco_hydro_cc PF11790.8 EXF73593.1 - 1.5e-71 240.8 0.5 1.7e-71 240.5 0.5 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core Thiolase_N PF00108.23 EXF73594.1 - 3.8e-66 223.1 0.3 4.9e-66 222.7 0.3 1.1 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EXF73594.1 - 6.7e-40 135.6 0.2 1.5e-39 134.5 0.2 1.6 1 0 0 1 1 1 1 Thiolase, C-terminal domain Sulfate_transp PF00916.20 EXF73595.1 - 4.8e-79 265.8 10.0 7.5e-79 265.2 10.0 1.3 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 EXF73595.1 - 3.3e-16 59.0 0.0 9.1e-16 57.6 0.0 1.7 2 0 0 2 2 2 1 STAS domain STAS_2 PF13466.6 EXF73595.1 - 0.00021 21.6 0.0 0.00052 20.3 0.0 1.7 1 0 0 1 1 1 1 STAS domain MFS_MOT1 PF16983.5 EXF73595.1 - 0.00069 20.0 1.7 0.00069 20.0 1.7 2.5 2 0 0 2 2 2 1 Molybdate transporter of MFS superfamily Abhydrolase_3 PF07859.13 EXF73596.1 - 6e-11 42.6 0.1 1.1e-10 41.8 0.1 1.5 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hce2 PF14856.6 EXF73597.1 - 1.1e-18 67.4 0.2 1.5e-18 66.9 0.2 1.2 1 0 0 1 1 1 1 Pathogen effector; putative necrosis-inducing factor DUF3012 PF11216.8 EXF73597.1 - 0.067 13.2 0.2 0.15 12.1 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3012) BTB PF00651.31 EXF73598.1 - 0.0033 17.6 0.0 0.0074 16.5 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain NPP1 PF05630.11 EXF73599.1 - 2.1e-60 204.2 1.1 2.4e-60 204.0 1.1 1.0 1 0 0 1 1 1 1 Necrosis inducing protein (NPP1) MCU PF04678.13 EXF73599.1 - 0.072 13.2 0.1 0.11 12.6 0.1 1.2 1 0 0 1 1 1 0 Mitochondrial calcium uniporter ECH_1 PF00378.20 EXF73600.1 - 7e-16 58.3 0.0 1.2e-15 57.6 0.0 1.3 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Formyl_trans_C PF02911.18 EXF73600.1 - 1.3e-08 34.9 0.0 3.1e-08 33.8 0.0 1.5 1 0 0 1 1 1 1 Formyl transferase, C-terminal domain DUF3636 PF12331.8 EXF73601.1 - 1e-40 139.0 0.2 2.1e-40 138.0 0.2 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3636) TMF_TATA_bd PF12325.8 EXF73601.1 - 0.29 11.4 5.5 0.56 10.4 5.5 1.5 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding CTP_transf_1 PF01148.20 EXF73602.1 - 1.1e-78 264.7 23.9 1.4e-78 264.3 23.9 1.1 1 0 0 1 1 1 1 Cytidylyltransferase family Aldolase_II PF00596.21 EXF73603.1 - 3.5e-49 167.3 0.2 4.9e-49 166.8 0.2 1.2 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain ABC2_membrane PF01061.24 EXF73604.1 - 2.2e-77 259.2 62.6 3e-43 147.7 20.4 2.7 3 0 0 3 3 3 2 ABC-2 type transporter PDR_CDR PF06422.12 EXF73604.1 - 2.5e-35 120.2 2.8 1.5e-28 98.5 0.0 3.2 2 0 0 2 2 2 2 CDR ABC transporter ABC_tran PF00005.27 EXF73604.1 - 6.8e-34 117.3 2.5 4.8e-16 59.5 0.0 3.1 4 0 0 4 4 2 2 ABC transporter ABC_trans_N PF14510.6 EXF73604.1 - 4.3e-14 52.9 0.4 2e-13 50.7 0.4 2.2 1 0 0 1 1 1 1 ABC-transporter N-terminal ABC2_membrane_3 PF12698.7 EXF73604.1 - 1.8e-13 50.3 36.2 5.9e-10 38.8 10.6 2.5 2 0 0 2 2 2 2 ABC-2 family transporter protein RsgA_GTPase PF03193.16 EXF73604.1 - 6.7e-06 26.1 0.0 2.3e-05 24.4 0.0 1.8 2 0 0 2 2 2 1 RsgA GTPase AAA_25 PF13481.6 EXF73604.1 - 7.8e-06 25.6 0.1 0.0021 17.7 0.1 2.5 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 EXF73604.1 - 1.8e-05 24.4 0.0 0.011 15.4 0.2 2.9 3 0 0 3 3 2 1 P-loop containing region of AAA domain AAA_16 PF13191.6 EXF73604.1 - 2e-05 25.0 0.1 0.0058 17.0 0.1 2.8 2 0 0 2 2 2 1 AAA ATPase domain AAA_21 PF13304.6 EXF73604.1 - 7.7e-05 22.6 0.9 0.22 11.3 0.0 3.1 2 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system MMR_HSR1 PF01926.23 EXF73604.1 - 0.00026 21.1 0.0 0.15 12.2 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_22 PF13401.6 EXF73604.1 - 0.00064 20.0 0.2 0.065 13.5 0.1 2.8 2 1 0 2 2 2 1 AAA domain NACHT PF05729.12 EXF73604.1 - 0.0015 18.5 0.0 0.075 13.0 0.0 2.5 2 0 0 2 2 2 1 NACHT domain AAA_30 PF13604.6 EXF73604.1 - 0.0016 18.2 0.0 0.38 10.4 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EXF73604.1 - 0.0036 17.5 1.5 0.14 12.3 0.0 3.2 3 0 0 3 3 3 1 AAA domain AAA_23 PF13476.6 EXF73604.1 - 0.0068 16.9 0.3 0.0068 16.9 0.3 3.1 4 1 0 4 4 3 1 AAA domain AAA_28 PF13521.6 EXF73604.1 - 0.009 16.3 0.0 0.009 16.3 0.0 2.3 3 0 0 3 3 1 1 AAA domain AAA_18 PF13238.6 EXF73604.1 - 0.009 16.6 0.0 0.067 13.7 0.0 2.4 2 0 0 2 2 2 1 AAA domain cobW PF02492.19 EXF73604.1 - 0.021 14.4 0.3 0.48 10.0 0.1 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain dNK PF01712.19 EXF73604.1 - 0.033 14.1 0.0 0.11 12.4 0.0 1.8 2 0 0 2 2 2 0 Deoxynucleoside kinase FtsK_SpoIIIE PF01580.18 EXF73604.1 - 0.034 13.5 0.0 8 5.7 0.1 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family T2SSE PF00437.20 EXF73604.1 - 0.035 13.1 0.0 4.2 6.3 0.0 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA PF00004.29 EXF73604.1 - 0.049 14.0 0.1 2.7 8.4 0.0 3.1 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 EXF73604.1 - 0.061 13.7 0.0 4.1 7.8 0.0 2.5 2 0 0 2 2 2 0 RNA helicase AAA_17 PF13207.6 EXF73604.1 - 0.07 13.6 1.7 1.2 9.6 0.0 3.0 3 0 0 3 3 2 0 AAA domain TsaE PF02367.17 EXF73604.1 - 0.074 13.1 0.3 0.3 11.1 0.3 1.9 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_19 PF13245.6 EXF73604.1 - 0.093 13.1 0.0 13 6.1 0.0 2.5 2 0 0 2 2 2 0 AAA domain Oxidored_FMN PF00724.20 EXF73605.1 - 1.9e-87 293.7 0.0 2.2e-87 293.5 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family DJ-1_PfpI PF01965.24 EXF73606.1 - 5.3e-06 26.3 0.0 0.00022 21.1 0.0 2.7 1 1 0 1 1 1 1 DJ-1/PfpI family Fungal_trans PF04082.18 EXF73607.1 - 1.6e-19 70.0 0.1 2.5e-19 69.4 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF73607.1 - 4.2e-08 33.2 11.6 6.6e-08 32.6 11.6 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pox_A_type_inc PF04508.12 EXF73607.1 - 0.0074 16.1 3.2 0.016 15.0 3.2 1.5 1 0 0 1 1 1 1 Viral A-type inclusion protein repeat Peptidase_S8 PF00082.22 EXF73608.1 - 7.7e-29 100.9 1.9 1e-28 100.5 1.9 1.2 1 0 0 1 1 1 1 Subtilase family fn3_5 PF06280.12 EXF73608.1 - 2.9e-11 44.1 0.0 8.2e-11 42.6 0.0 1.8 1 0 0 1 1 1 1 Fn3-like domain Alpha-L-AF_C PF06964.12 EXF73609.1 - 2.3e-21 76.6 0.0 4e-21 75.9 0.0 1.4 1 0 0 1 1 1 1 Alpha-L-arabinofuranosidase C-terminal domain Aspzincin_M35 PF14521.6 EXF73610.1 - 3.5e-05 24.4 0.2 3.8 8.0 0.0 3.9 2 1 1 3 3 3 3 Lysine-specific metallo-endopeptidase HRXXH PF13933.6 EXF73610.1 - 0.0088 15.6 0.0 0.037 13.6 0.0 2.0 2 0 0 2 2 2 1 Putative peptidase family LrgB PF04172.16 EXF73610.1 - 0.44 10.0 3.3 0.69 9.4 3.3 1.2 1 0 0 1 1 1 0 LrgB-like family Sugar_tr PF00083.24 EXF73611.1 - 6.7e-86 288.9 19.0 8.4e-86 288.6 19.0 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF73611.1 - 1.1e-19 70.7 44.7 5.2e-18 65.1 25.9 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF4880 PF16220.5 EXF73611.1 - 0.095 12.6 0.4 0.28 11.1 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4880) ABC_tran PF00005.27 EXF73612.1 - 9.3e-43 146.0 0.0 7.5e-22 78.3 0.0 2.4 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EXF73612.1 - 4.5e-17 62.6 26.1 3.3e-12 46.6 4.6 2.5 2 0 0 2 2 2 2 ABC transporter transmembrane region AAA_21 PF13304.6 EXF73612.1 - 5.1e-10 39.6 3.4 0.00038 20.4 0.0 4.1 4 1 1 5 5 4 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EXF73612.1 - 9.8e-09 35.0 0.7 0.058 12.8 0.0 3.5 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EXF73612.1 - 0.00043 20.9 0.1 0.0012 19.4 0.1 1.7 2 0 0 2 2 1 1 AAA domain AAA_29 PF13555.6 EXF73612.1 - 0.0041 16.8 0.6 0.043 13.6 0.1 2.4 2 0 0 2 2 2 1 P-loop containing region of AAA domain NB-ARC PF00931.22 EXF73612.1 - 0.0041 16.3 0.0 0.01 15.0 0.0 1.6 1 0 0 1 1 1 1 NB-ARC domain T2SSE PF00437.20 EXF73612.1 - 0.0051 15.9 0.2 2.2 7.3 0.0 2.3 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_16 PF13191.6 EXF73612.1 - 0.0097 16.3 0.0 0.44 10.9 0.0 2.6 2 0 0 2 2 2 1 AAA ATPase domain Rad17 PF03215.15 EXF73612.1 - 0.013 15.4 0.0 0.026 14.5 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_15 PF13175.6 EXF73612.1 - 0.017 14.8 0.0 0.11 12.1 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain RsgA_GTPase PF03193.16 EXF73612.1 - 0.027 14.4 0.8 0.1 12.5 0.1 2.1 2 0 0 2 2 2 0 RsgA GTPase cobW PF02492.19 EXF73612.1 - 0.043 13.4 1.2 2.8 7.5 0.2 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_27 PF13514.6 EXF73612.1 - 0.06 12.9 0.0 0.19 11.3 0.0 1.7 2 0 0 2 2 2 0 AAA domain Adeno_IVa2 PF02456.15 EXF73612.1 - 0.067 12.0 0.1 0.11 11.3 0.1 1.2 1 0 0 1 1 1 0 Adenovirus IVa2 protein AAA_22 PF13401.6 EXF73612.1 - 0.073 13.3 0.3 0.6 10.4 0.0 2.6 3 0 0 3 3 3 0 AAA domain AAA_30 PF13604.6 EXF73612.1 - 0.08 12.7 0.2 1.6 8.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain Dynamin_N PF00350.23 EXF73612.1 - 0.088 12.9 1.1 0.75 9.8 0.0 2.5 2 0 0 2 2 2 0 Dynamin family AAA PF00004.29 EXF73612.1 - 0.14 12.6 0.0 0.43 11.0 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) TrwB_AAD_bind PF10412.9 EXF73612.1 - 0.15 11.0 0.3 12 4.6 0.0 2.4 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain ATPase_2 PF01637.18 EXF73612.1 - 0.17 11.7 0.2 0.75 9.7 0.0 2.0 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea TMEM125 PF15109.6 EXF73612.1 - 1.1 9.7 7.0 0.38 11.1 1.9 2.9 2 0 0 2 2 2 0 TMEM125 protein family MTHFR PF02219.17 EXF73613.1 - 2.7e-111 371.5 0.0 4.2e-111 370.9 0.0 1.2 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase DUF3425 PF11905.8 EXF73614.1 - 6.2e-13 48.8 1.1 2.2e-12 47.1 1.1 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF3425) HTH_Tnp_Tc5 PF03221.16 EXF73615.1 - 3e-16 59.2 0.9 3.9e-05 23.6 0.1 5.3 6 0 0 6 6 6 4 Tc5 transposase DNA-binding domain Homeobox_KN PF05920.11 EXF73615.1 - 4.1e-16 58.6 1.4 4.1e-16 58.6 1.4 3.2 4 0 0 4 4 4 1 Homeobox KN domain Homeodomain PF00046.29 EXF73615.1 - 6.9e-06 25.8 0.6 2.1e-05 24.3 0.6 1.8 1 0 0 1 1 1 1 Homeodomain zf-C2H2 PF00096.26 EXF73615.1 - 0.00017 21.9 16.0 0.026 14.9 3.8 4.2 4 0 0 4 4 4 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EXF73615.1 - 0.004 17.9 3.9 0.004 17.9 3.9 4.9 5 0 0 5 5 5 1 C2H2-type zinc finger Elf1 PF05129.13 EXF73615.1 - 2.7 8.1 5.7 4.1 7.5 3.9 2.2 2 1 1 3 3 3 0 Transcription elongation factor Elf1 like Patatin PF01734.22 EXF73616.1 - 1.1e-24 87.8 0.0 1.6e-24 87.2 0.0 1.3 1 0 0 1 1 1 1 Patatin-like phospholipase Tetraspanin PF00335.20 EXF73617.1 - 0.016 15.0 0.2 0.028 14.1 0.2 1.5 1 1 0 1 1 1 0 Tetraspanin family RskA PF10099.9 EXF73617.1 - 0.022 15.1 1.3 0.031 14.6 1.3 1.2 1 0 0 1 1 1 0 Anti-sigma-K factor rskA Tic110 PF16940.5 EXF73617.1 - 0.31 9.5 2.2 0.38 9.2 2.2 1.0 1 0 0 1 1 1 0 Chloroplast envelope transporter B277 PF17623.2 EXF73617.1 - 7 5.6 5.0 10 5.1 5.0 1.2 1 0 0 1 1 1 0 Domain of unknown function MFS_1 PF07690.16 EXF73620.1 - 1.2e-22 80.4 25.3 1.2e-22 80.4 25.3 1.6 1 1 0 2 2 2 1 Major Facilitator Superfamily 4HBT PF03061.22 EXF73621.1 - 1.8e-06 28.2 0.1 2.8e-06 27.6 0.1 1.3 1 0 0 1 1 1 1 Thioesterase superfamily SR-25 PF10500.9 EXF73621.1 - 0.02 14.5 7.0 0.024 14.3 7.0 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein CCDC24 PF15669.5 EXF73621.1 - 0.51 10.2 1.9 0.69 9.7 1.9 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 24 family rRNA_processing PF08524.11 EXF73622.1 - 0.0014 18.7 18.1 0.066 13.2 0.7 2.4 2 0 0 2 2 2 2 rRNA processing Hamartin PF04388.12 EXF73622.1 - 2.9 6.5 15.7 3.6 6.1 15.7 1.1 1 0 0 1 1 1 0 Hamartin protein RhoGAP PF00620.27 EXF73623.1 - 9.3e-45 152.2 0.0 9.3e-45 152.2 0.0 2.7 3 2 1 4 4 4 1 RhoGAP domain LIM PF00412.22 EXF73623.1 - 1.9e-12 47.2 18.3 1.8e-06 28.1 2.5 3.2 2 1 0 2 2 2 2 LIM domain DUF4407 PF14362.6 EXF73623.1 - 0.37 10.1 5.1 0.74 9.1 5.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TMF_TATA_bd PF12325.8 EXF73623.1 - 0.63 10.3 9.0 0.082 13.1 1.2 3.1 3 0 0 3 3 3 0 TATA element modulatory factor 1 TATA binding Fez1 PF06818.15 EXF73623.1 - 0.76 10.2 12.5 2.2 8.7 12.5 1.7 1 0 0 1 1 1 0 Fez1 SlyX PF04102.12 EXF73623.1 - 2.7 8.7 11.1 0.11 13.2 0.8 3.4 3 1 0 3 3 3 0 SlyX Desulfoferrod_N PF06397.12 EXF73623.1 - 2.9 7.6 6.5 12 5.6 0.8 3.0 2 1 1 3 3 3 0 Desulfoferrodoxin, N-terminal domain Metal_resist PF13801.6 EXF73623.1 - 4 7.6 7.2 13 6.0 7.2 1.9 1 0 0 1 1 1 0 Heavy-metal resistance PRKG1_interact PF15898.5 EXF73623.1 - 4.9 8.1 10.3 50 4.9 0.2 3.3 2 0 0 2 2 2 0 cGMP-dependent protein kinase interacting domain Zn-ribbon_8 PF09723.10 EXF73623.1 - 5.2 7.3 17.4 1.1 9.4 1.2 4.4 4 0 0 4 4 4 0 Zinc ribbon domain IFT20 PF14931.6 EXF73623.1 - 7.2 6.8 11.8 0.3 11.3 3.2 2.4 2 0 0 2 2 2 0 Intraflagellar transport complex B, subunit 20 CLASP_N PF12348.8 EXF73624.1 - 1.8e-136 453.0 0.0 1.5e-88 296.2 0.0 2.5 2 0 0 2 2 2 2 CLASP N terminal HEAT PF02985.22 EXF73624.1 - 3e-05 23.9 0.1 9.8 6.7 0.0 5.2 5 0 0 5 5 5 2 HEAT repeat Cnd1 PF12717.7 EXF73624.1 - 0.011 15.8 0.0 1.9 8.5 0.0 3.2 2 1 1 3 3 3 0 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 EXF73624.1 - 0.04 12.5 0.0 0.44 9.1 0.0 2.6 3 0 0 3 3 3 0 Adaptin N terminal region Rrn6 PF10214.9 EXF73624.1 - 0.048 12.2 5.1 0.074 11.5 5.1 1.4 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor BSP PF04450.12 EXF73625.1 - 7.7e-78 261.0 0.0 9.2e-78 260.8 0.0 1.1 1 0 0 1 1 1 1 Peptidase of plants and bacteria DUF4813 PF16072.5 EXF73627.1 - 0.037 13.7 0.0 0.042 13.5 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4813) FtsJ PF01728.19 EXF73629.1 - 9e-41 139.9 1.0 2.2e-40 138.6 1.0 1.6 1 1 0 1 1 1 1 FtsJ-like methyltransferase CCDC144C PF14915.6 EXF73630.1 - 4.5e-05 22.7 61.2 0.00035 19.8 21.3 3.2 1 1 2 3 3 3 3 CCDC144C protein coiled-coil region AT_hook PF02178.19 EXF73630.1 - 3.5 7.8 11.3 0.39 10.7 3.4 3.3 2 0 0 2 2 2 0 AT hook motif OST3_OST6 PF04756.13 EXF73631.1 - 3.6e-111 371.2 0.0 4.1e-111 371.0 0.0 1.0 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family HXXEE PF13787.6 EXF73631.1 - 0.11 13.4 0.3 0.11 13.4 0.3 1.9 2 0 0 2 2 2 0 Protein of unknown function with HXXEE motif MerC PF03203.14 EXF73631.1 - 0.22 12.0 5.6 1.9 9.0 0.1 2.6 2 0 0 2 2 2 0 MerC mercury resistance protein Pex14_N PF04695.13 EXF73631.1 - 0.22 12.2 0.2 0.43 11.2 0.2 1.5 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF3169 PF11368.8 EXF73631.1 - 0.94 8.9 3.4 4.2 6.8 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3169) Glyco_hydro_6 PF01341.17 EXF73632.1 - 5.6e-98 328.4 0.1 7.4e-98 328.0 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 6 WD40 PF00400.32 EXF73633.1 - 1e-45 152.8 21.4 1.1e-08 35.5 0.2 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EXF73633.1 - 6.7e-09 35.9 0.7 0.098 13.0 0.0 4.5 2 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EXF73633.1 - 1.4e-05 23.9 6.5 0.078 11.6 0.1 4.3 1 1 3 4 4 4 3 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 EXF73633.1 - 0.0024 16.9 0.1 8.3 5.3 0.0 4.0 2 2 1 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 EXF73633.1 - 0.0077 15.6 0.0 0.5 9.6 0.0 2.3 2 1 0 2 2 2 1 WD40-like domain PD40 PF07676.12 EXF73633.1 - 0.018 15.0 0.6 22 5.1 0.0 4.4 6 0 0 6 6 6 0 WD40-like Beta Propeller Repeat TAF8_C PF10406.9 EXF73634.1 - 5.4e-17 62.1 2.5 6.1e-17 61.9 0.2 2.4 2 0 0 2 2 2 1 Transcription factor TFIID complex subunit 8 C-term Bromo_TP PF07524.13 EXF73634.1 - 8.4e-10 38.5 0.0 1.2e-09 38.0 0.0 1.2 1 0 0 1 1 1 1 Bromodomain associated Histone PF00125.24 EXF73634.1 - 0.081 13.3 0.0 0.081 13.3 0.0 2.7 3 0 0 3 3 3 0 Core histone H2A/H2B/H3/H4 Pkinase_Tyr PF07714.17 EXF73635.1 - 7.3e-16 58.2 0.0 3.6e-13 49.4 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase LRR_8 PF13855.6 EXF73635.1 - 3.7e-14 52.2 4.4 1.2e-06 28.1 0.3 4.0 3 1 1 4 4 4 3 Leucine rich repeat Pkinase PF00069.25 EXF73635.1 - 8e-13 48.3 0.0 6.4e-12 45.4 0.0 2.0 1 1 1 2 2 2 1 Protein kinase domain LRR_4 PF12799.7 EXF73635.1 - 9.2e-09 35.5 4.1 0.21 12.0 0.7 5.1 3 1 2 5 5 5 4 Leucine Rich repeats (2 copies) Kdo PF06293.14 EXF73635.1 - 4.9e-05 22.8 0.0 8.3e-05 22.0 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family LRR_9 PF14580.6 EXF73635.1 - 0.0021 17.6 0.2 0.16 11.4 0.1 3.0 1 1 2 3 3 3 2 Leucine-rich repeat LRR_1 PF00560.33 EXF73635.1 - 0.016 15.6 5.9 7.7 7.5 0.0 5.5 2 2 0 2 2 2 0 Leucine Rich Repeat APH PF01636.23 EXF73635.1 - 0.082 12.8 0.2 0.17 11.8 0.0 1.6 2 0 0 2 2 2 0 Phosphotransferase enzyme family UME PF08064.13 EXF73635.1 - 0.13 12.2 0.0 0.25 11.2 0.0 1.5 1 0 0 1 1 1 0 UME (NUC010) domain 2OG-FeII_Oxy_2 PF13532.6 EXF73636.1 - 1.7e-29 103.4 0.0 2.5e-29 102.9 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Isochorismatase PF00857.20 EXF73636.1 - 2.1e-21 76.9 0.0 7.3e-21 75.1 0.0 2.0 2 1 0 2 2 2 1 Isochorismatase family GST_C_2 PF13410.6 EXF73636.1 - 0.00015 21.7 0.1 0.00032 20.7 0.1 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EXF73636.1 - 0.0035 17.5 0.1 0.0068 16.6 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EXF73636.1 - 0.01 16.0 0.0 0.022 15.0 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain SHMT PF00464.19 EXF73637.1 - 6.9e-196 650.6 0.0 8.1e-196 650.3 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Beta_elim_lyase PF01212.21 EXF73637.1 - 0.0095 15.2 0.0 0.028 13.7 0.0 1.7 1 1 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 EXF73637.1 - 0.02 14.2 0.0 0.029 13.7 0.0 1.3 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Ribosomal_L19e PF01280.20 EXF73638.1 - 3.8e-61 205.4 6.3 3.8e-61 205.4 6.3 1.9 1 1 1 2 2 2 1 Ribosomal protein L19e Gcn1_N PF12074.8 EXF73639.1 - 4.9e-127 424.1 11.1 5.2e-126 420.7 11.1 3.0 1 0 0 1 1 1 1 Generalcontrol nonderepressible 1 (Gcn1) N-terminal HEAT PF02985.22 EXF73639.1 - 8.6e-31 103.4 45.8 0.012 15.8 0.1 22.8 27 0 0 27 27 24 8 HEAT repeat HEAT_EZ PF13513.6 EXF73639.1 - 2.1e-28 98.4 55.1 1.2e-05 25.7 0.0 20.4 19 4 7 26 26 23 6 HEAT-like repeat HEAT_2 PF13646.6 EXF73639.1 - 5.7e-25 87.5 53.6 0.00011 22.6 4.0 16.5 11 4 6 19 19 19 10 HEAT repeats Cnd1 PF12717.7 EXF73639.1 - 4.4e-14 52.8 5.9 0.51 10.4 0.3 11.0 8 3 4 12 12 11 3 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 EXF73639.1 - 1.8e-13 50.9 0.0 0.36 11.4 0.0 9.5 7 2 3 10 10 9 2 Vacuolar 14 Fab1-binding region ParcG PF10274.9 EXF73639.1 - 4e-11 43.4 1.3 0.00088 19.4 0.0 6.5 4 2 1 6 6 6 2 Parkin co-regulated protein CLASP_N PF12348.8 EXF73639.1 - 8.3e-11 41.9 0.0 0.13 11.8 0.0 6.0 4 1 1 5 5 5 2 CLASP N terminal Adaptin_N PF01602.20 EXF73639.1 - 2.9e-07 29.5 13.0 0.13 10.8 5.1 8.1 8 2 2 10 10 10 2 Adaptin N terminal region MMS19_C PF12460.8 EXF73639.1 - 8.4e-07 28.4 17.4 0.0011 18.2 0.2 7.0 6 2 1 7 7 7 2 RNAPII transcription regulator C-terminal TIP120 PF08623.10 EXF73639.1 - 1.2e-05 25.2 0.1 0.041 13.7 0.0 5.5 5 1 1 6 6 6 1 TATA-binding protein interacting (TIP20) DUF3385 PF11865.8 EXF73639.1 - 0.00018 21.5 0.0 1.5 8.7 0.0 5.7 6 2 0 6 6 6 1 Domain of unknown function (DUF3385) Ecm29 PF13001.7 EXF73639.1 - 0.00033 19.5 0.3 2.9 6.5 0.0 5.2 4 2 1 5 5 5 1 Proteasome stabiliser DUF937 PF06078.11 EXF73639.1 - 0.0047 17.5 11.3 4 8.1 0.0 7.4 6 2 1 7 7 7 1 Bacterial protein of unknown function (DUF937) TFCD_C PF12612.8 EXF73639.1 - 0.0058 16.5 0.3 0.17 11.7 0.0 3.6 3 0 0 3 3 3 1 Tubulin folding cofactor D C terminal FANCI_S2 PF14676.6 EXF73639.1 - 0.006 16.9 0.4 1.6 9.0 0.1 4.1 3 0 0 3 3 3 1 FANCI solenoid 2 Tti2 PF10521.9 EXF73639.1 - 0.013 15.0 6.0 12 5.4 0.0 6.5 7 1 1 8 8 8 0 Tti2 family Imm49 PF15575.6 EXF73639.1 - 0.031 14.1 1.3 2.5 7.8 0.1 3.1 2 0 0 2 2 2 0 Immunity protein 49 Dopey_N PF04118.14 EXF73639.1 - 0.13 11.3 1.2 12 4.9 0.0 4.4 4 2 2 6 6 6 0 Dopey, N-terminal RPAP3_C PF13877.6 EXF73639.1 - 0.17 12.5 0.2 2.7 8.6 0.0 3.4 3 0 0 3 3 1 0 Potential Monad-binding region of RPAP3 RIX1 PF08167.12 EXF73639.1 - 0.22 11.3 4.1 0.63 9.8 0.2 3.8 2 1 1 3 3 3 0 rRNA processing/ribosome biogenesis HEAT_PBS PF03130.16 EXF73639.1 - 0.24 12.2 14.7 65 4.6 0.1 8.4 8 0 0 8 8 6 0 PBS lyase HEAT-like repeat Ipi1_N PF12333.8 EXF73639.1 - 0.57 10.8 4.1 1.4 9.6 0.1 4.0 5 0 0 5 5 2 0 Rix1 complex component involved in 60S ribosome maturation HA2 PF04408.23 EXF73640.1 - 1.8e-14 53.9 0.0 1.8e-14 53.9 0.0 2.7 3 0 0 3 3 3 1 Helicase associated domain (HA2) Helicase_C PF00271.31 EXF73640.1 - 2.5e-13 50.3 0.0 9.1e-13 48.5 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EXF73640.1 - 2.9e-11 43.4 0.0 5.9e-11 42.4 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EXF73640.1 - 5.4e-08 33.2 0.1 2.1e-07 31.3 0.1 2.0 1 0 0 1 1 1 1 AAA domain OB_NTP_bind PF07717.16 EXF73640.1 - 1.5e-05 25.2 0.0 3.3e-05 24.2 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold ABC_tran PF00005.27 EXF73640.1 - 0.0061 17.1 0.0 0.023 15.2 0.0 2.0 1 0 0 1 1 1 1 ABC transporter ATPase PF06745.13 EXF73640.1 - 0.032 13.6 0.0 0.076 12.3 0.0 1.6 1 0 0 1 1 1 0 KaiC Neuraminidase PF18413.1 EXF73640.1 - 0.036 13.7 0.1 0.036 13.7 0.1 2.0 2 0 0 2 2 2 0 Neuraminidase-like domain AAA_29 PF13555.6 EXF73640.1 - 0.041 13.6 0.0 0.094 12.5 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain NACHT PF05729.12 EXF73640.1 - 0.062 13.2 0.2 0.3 11.0 0.0 2.2 2 0 0 2 2 2 0 NACHT domain T2SSE PF00437.20 EXF73640.1 - 0.093 11.8 0.0 0.2 10.7 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein RsgA_GTPase PF03193.16 EXF73640.1 - 0.14 12.0 0.0 0.51 10.2 0.0 1.9 2 0 0 2 2 2 0 RsgA GTPase AAA_23 PF13476.6 EXF73640.1 - 0.74 10.3 0.0 0.74 10.3 0.0 3.5 4 0 0 4 4 4 0 AAA domain RRM_1 PF00076.22 EXF73641.1 - 8.8e-42 140.8 0.1 4.3e-12 45.7 0.0 4.5 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EXF73641.1 - 2.3e-33 113.9 0.0 8.6e-27 92.8 0.0 3.6 3 0 0 3 3 3 3 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 EXF73641.1 - 2.7e-08 33.7 0.0 0.0018 18.2 0.0 3.3 3 0 0 3 3 3 2 Nup53/35/40-type RNA recognition motif RRM_5 PF13893.6 EXF73641.1 - 2e-07 30.7 0.0 1.5e-06 27.8 0.0 2.3 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM PF05172.13 EXF73641.1 - 0.00021 21.2 0.0 0.44 10.5 0.0 3.1 2 1 1 3 3 3 2 Nup53/35/40-type RNA recognition motif TPR_14 PF13428.6 EXF73641.1 - 0.0036 18.0 2.1 0.5 11.3 0.0 4.0 3 0 0 3 3 3 1 Tetratricopeptide repeat Neur_chan_memb PF02932.16 EXF73641.1 - 1.7 8.7 3.4 4.5 7.3 3.4 1.7 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF702 PF05142.12 EXF73641.1 - 6 7.3 6.2 18 5.8 6.2 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF702) CFEM PF05730.11 EXF73642.1 - 1.2e-12 47.7 7.2 1.9e-12 47.1 7.2 1.3 1 0 0 1 1 1 1 CFEM domain SKG6 PF08693.10 EXF73642.1 - 0.00018 20.9 1.3 0.00041 19.7 1.3 1.6 1 0 0 1 1 1 1 Transmembrane alpha-helix domain SPX PF03105.19 EXF73642.1 - 0.38 10.6 7.7 0.46 10.3 7.7 1.2 1 0 0 1 1 1 0 SPX domain Ndc1_Nup PF09531.10 EXF73642.1 - 7.9 5.0 11.8 9.8 4.7 11.8 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Ribosomal_L22 PF00237.19 EXF73643.1 - 2.2e-22 79.3 0.1 4e-22 78.4 0.1 1.5 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e DUF3619 PF12279.8 EXF73643.1 - 0.43 10.9 2.4 2.8 8.3 0.1 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3619) GlutR_dimer PF00745.20 EXF73643.1 - 0.97 9.9 5.0 0.99 9.9 2.2 2.2 2 0 0 2 2 2 0 Glutamyl-tRNAGlu reductase, dimerisation domain COX6C PF02937.15 EXF73644.1 - 0.0031 17.6 0.0 0.0037 17.4 0.0 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIc Mitochondr_Som1 PF11093.8 EXF73645.1 - 2.7e-26 91.4 0.1 3.3e-26 91.1 0.1 1.1 1 0 0 1 1 1 1 Mitochondrial export protein Som1 Hydrolase_6 PF13344.6 EXF73647.1 - 3.5e-23 81.6 0.0 9.3e-23 80.3 0.0 1.8 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EXF73647.1 - 5.1e-14 52.1 0.0 2.3e-13 50.0 0.0 2.2 2 0 0 2 2 2 1 HAD-hyrolase-like Hydrolase PF00702.26 EXF73647.1 - 0.0032 17.8 0.0 4.6 7.5 0.0 3.0 2 1 1 3 3 3 2 haloacid dehalogenase-like hydrolase adh_short_C2 PF13561.6 EXF73648.1 - 2.8e-52 177.6 0.1 3.7e-52 177.2 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF73648.1 - 4.3e-40 137.3 1.2 7.4e-40 136.5 1.2 1.4 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EXF73648.1 - 1.3e-08 34.9 0.6 2e-08 34.3 0.6 1.2 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EXF73648.1 - 0.03 13.4 0.0 0.054 12.6 0.0 1.4 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein MR_MLE_C PF13378.6 EXF73649.1 - 3.5e-42 144.4 0.0 4.6e-42 144.1 0.0 1.1 1 0 0 1 1 1 1 Enolase C-terminal domain-like MR_MLE_N PF02746.16 EXF73649.1 - 3.9e-10 40.0 0.0 6e-10 39.4 0.0 1.2 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain Glyco_hydro_42 PF02449.15 EXF73649.1 - 0.075 12.4 0.0 0.7 9.2 0.0 2.0 2 0 0 2 2 2 0 Beta-galactosidase Fungal_trans PF04082.18 EXF73650.1 - 4.7e-26 91.4 2.3 9.4e-26 90.4 2.3 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain PBP1_TM PF14812.6 EXF73650.1 - 9.6 6.7 8.6 1.9 8.9 4.7 1.8 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Ctr PF04145.15 EXF73651.1 - 2.9e-38 131.8 0.2 3.5e-38 131.5 0.2 1.1 1 0 0 1 1 1 1 Ctr copper transporter family Ferric_reduct PF01794.19 EXF73652.1 - 9.5e-25 87.1 8.3 2.4e-24 85.8 8.3 1.7 1 0 0 1 1 1 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 EXF73652.1 - 5.3e-14 52.6 0.0 8.3e-14 52.0 0.0 1.2 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EXF73652.1 - 6.6e-10 39.0 0.0 1.4e-09 38.0 0.0 1.6 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_1 PF00175.21 EXF73652.1 - 5.4e-06 27.0 0.0 1.1e-05 26.0 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Fungal_trans PF04082.18 EXF73653.1 - 9.7e-15 54.3 0.1 1.5e-14 53.6 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF73653.1 - 5.6e-07 29.6 8.6 9.3e-07 28.9 8.6 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain GATase_5 PF13507.6 EXF73655.1 - 5.5e-96 320.6 0.0 8.1e-96 320.1 0.0 1.2 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain AIRS_C PF02769.22 EXF73655.1 - 9e-37 126.6 0.3 4.2e-24 85.5 0.1 2.6 2 0 0 2 2 2 2 AIR synthase related protein, C-terminal domain FGAR-AT_N PF18076.1 EXF73655.1 - 5.9e-24 84.3 0.0 1.1e-23 83.4 0.0 1.5 1 0 0 1 1 1 1 Formylglycinamide ribonucleotide amidotransferase N-terminal FGAR-AT_linker PF18072.1 EXF73655.1 - 5.3e-23 81.3 0.0 1.3e-22 80.0 0.0 1.8 1 0 0 1 1 1 1 Formylglycinamide ribonucleotide amidotransferase linker domain PQ-loop PF04193.14 EXF73656.1 - 1.2e-17 63.4 4.5 2.7e-12 46.3 1.3 2.7 2 0 0 2 2 2 2 PQ loop repeat BTRD1 PF17660.1 EXF73657.1 - 0.023 14.5 0.0 0.051 13.4 0.0 1.5 1 0 0 1 1 1 0 Bacterial tandem repeat domain 1 HTH_WhiA PF02650.14 EXF73657.1 - 0.055 13.8 0.0 0.12 12.7 0.0 1.5 1 0 0 1 1 1 0 WhiA C-terminal HTH domain MTHFR PF02219.17 EXF73658.1 - 6.8e-101 337.4 0.0 9.7e-101 336.9 0.0 1.2 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase tRNA-synt_1 PF00133.22 EXF73659.1 - 1.4e-51 175.5 0.1 2.3e-19 69.1 0.2 6.1 2 1 3 5 5 5 5 tRNA synthetases class I (I, L, M and V) tRNA-synt_1_2 PF13603.6 EXF73659.1 - 1.3e-41 142.2 0.0 2.2e-41 141.4 0.0 1.4 1 0 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1g PF09334.11 EXF73659.1 - 4.3e-29 101.4 1.3 1.4e-19 70.2 0.0 4.5 4 1 1 5 5 5 3 tRNA synthetases class I (M) Anticodon_1 PF08264.13 EXF73659.1 - 2.1e-12 47.2 0.0 4.2e-12 46.3 0.0 1.5 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.19 EXF73659.1 - 0.0048 16.3 0.0 1.8 7.8 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain tRNA-synt_1c PF00749.21 EXF73659.1 - 0.12 11.2 0.3 6.5 5.5 0.1 2.2 2 0 0 2 2 2 0 tRNA synthetases class I (E and Q), catalytic domain cobW PF02492.19 EXF73660.1 - 5.4e-41 140.1 0.0 8.5e-41 139.5 0.0 1.3 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain MobB PF03205.14 EXF73660.1 - 0.00025 20.9 0.9 0.0011 18.9 0.0 2.1 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B RsgA_GTPase PF03193.16 EXF73660.1 - 0.0072 16.2 0.0 4.7 7.1 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase Viral_helicase1 PF01443.18 EXF73660.1 - 0.0086 15.8 0.0 0.021 14.6 0.0 1.7 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase AAA_29 PF13555.6 EXF73660.1 - 0.012 15.3 0.5 0.34 10.7 0.1 2.9 3 0 0 3 3 3 0 P-loop containing region of AAA domain AAA_22 PF13401.6 EXF73660.1 - 0.012 15.8 0.0 0.035 14.4 0.0 1.8 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 EXF73660.1 - 0.068 13.1 0.1 0.15 12.0 0.1 1.5 1 0 0 1 1 1 0 NTPase DUF2075 PF09848.9 EXF73660.1 - 0.071 12.3 0.0 0.13 11.5 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_16 PF13191.6 EXF73660.1 - 0.085 13.2 0.1 0.45 10.9 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain DUF463 PF04317.12 EXF73660.1 - 0.16 10.8 0.1 0.26 10.2 0.1 1.3 1 0 0 1 1 1 0 YcjX-like family, DUF463 Pyr_redox_2 PF07992.14 EXF73663.1 - 3.1e-31 108.7 0.2 3.7e-31 108.5 0.2 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EXF73663.1 - 8e-11 42.3 0.1 3.1e-09 37.3 0.0 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EXF73663.1 - 2.1e-06 27.8 2.0 0.085 12.9 0.0 3.5 4 0 0 4 4 4 2 FAD-NAD(P)-binding K_oxygenase PF13434.6 EXF73663.1 - 0.00042 19.6 0.4 0.094 11.8 0.0 2.8 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) HI0933_like PF03486.14 EXF73663.1 - 0.016 13.9 2.3 0.88 8.2 0.1 3.2 3 1 1 4 4 4 0 HI0933-like protein GIDA PF01134.22 EXF73663.1 - 0.017 14.2 3.2 0.49 9.4 0.2 2.7 2 1 1 3 3 3 0 Glucose inhibited division protein A Catalase_C PF18011.1 EXF73663.1 - 0.034 13.8 0.1 0.065 12.9 0.1 1.4 1 0 0 1 1 1 0 C-terminal domain found in long catalases DAO PF01266.24 EXF73663.1 - 0.035 13.7 9.0 4.4 6.8 0.0 3.7 3 1 0 4 4 4 0 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 EXF73663.1 - 0.047 12.7 1.7 0.15 11.0 0.0 2.4 3 0 0 3 3 3 0 Lycopene cyclase protein FAD_binding_2 PF00890.24 EXF73663.1 - 0.068 12.2 0.2 9.2 5.2 0.0 3.0 3 0 0 3 3 3 0 FAD binding domain DUF4988 PF16378.5 EXF73663.1 - 0.2 11.3 2.1 0.76 9.4 0.3 2.3 2 1 0 2 2 2 0 Domain of unknown function PBP PF01161.20 EXF73664.1 - 6.9e-17 62.0 0.1 1.2e-16 61.3 0.1 1.3 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein WD40_4 PF16300.5 EXF73665.1 - 0.032 14.1 0.2 0.072 13.0 0.0 1.7 2 0 0 2 2 2 0 Type of WD40 repeat DUF572 PF04502.13 EXF73666.1 - 3.5e-68 230.7 7.2 4e-68 230.5 7.2 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF572) DUF951 PF06107.11 EXF73666.1 - 0.16 11.9 0.5 13 5.7 0.0 2.3 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF951) DUF3446 PF11928.8 EXF73666.1 - 1.7 9.0 11.1 3.1 8.2 11.1 1.3 1 0 0 1 1 1 0 Early growth response N-terminal domain zf-ACC PF17848.1 EXF73666.1 - 1.8 8.7 4.0 9.8 6.4 1.0 2.3 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain GCP_N_terminal PF17681.1 EXF73667.1 - 3.9e-35 121.9 0.0 5.9e-35 121.4 0.0 1.3 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 EXF73667.1 - 9.1e-25 87.7 0.0 2.3e-24 86.4 0.0 1.6 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal GCP5-Mod21 PF14609.6 EXF73667.1 - 5.5e-09 34.9 0.1 7.9e-09 34.4 0.1 1.2 1 0 0 1 1 1 1 gamma-Tubulin ring complex non-core subunit mod21 Glyco_transf_15 PF01793.16 EXF73668.1 - 4.3e-116 387.7 8.3 5.2e-116 387.4 8.3 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase WD40 PF00400.32 EXF73669.1 - 1.5e-20 73.1 6.3 5.7e-06 27.0 0.7 6.3 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EXF73669.1 - 1.5e-09 38.0 0.1 0.00088 19.5 0.0 5.2 3 1 3 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 EXF73669.1 - 0.0009 18.9 3.2 0.3 10.6 0.0 2.3 1 1 1 2 2 2 2 PQQ-like domain DUF5046 PF16465.5 EXF73669.1 - 0.03 13.8 0.1 0.062 12.7 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5046) PQQ_3 PF13570.6 EXF73669.1 - 0.048 14.2 6.7 15 6.2 0.2 4.5 5 0 0 5 5 5 0 PQQ-like domain PQQ PF01011.21 EXF73669.1 - 0.19 11.7 1.9 56 3.9 0.1 3.9 4 0 0 4 4 4 0 PQQ enzyme repeat Aminotran_1_2 PF00155.21 EXF73670.1 - 8.4e-46 156.8 0.0 1.1e-45 156.4 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II MTS PF05175.14 EXF73671.1 - 9.6e-10 38.3 0.0 1e-08 34.9 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_31 PF13847.6 EXF73671.1 - 1.9e-07 31.0 0.0 6.1e-07 29.3 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EXF73671.1 - 7.3e-06 25.6 0.0 1e-05 25.1 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 EXF73671.1 - 1.1e-05 26.0 0.0 2.4e-05 24.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EXF73671.1 - 1.9e-05 24.5 0.0 3.6e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PrmC_N PF17827.1 EXF73671.1 - 4.6e-05 23.9 0.3 0.00013 22.5 0.1 1.9 2 0 0 2 2 1 1 PrmC N-terminal domain N6_Mtase PF02384.16 EXF73671.1 - 0.00038 19.8 0.0 0.00055 19.3 0.0 1.1 1 0 0 1 1 1 1 N-6 DNA Methylase Methyltransf_10 PF05971.12 EXF73671.1 - 0.0015 17.9 0.0 0.002 17.5 0.0 1.2 1 0 0 1 1 1 1 RNA methyltransferase FtsJ PF01728.19 EXF73671.1 - 0.0062 16.7 0.0 0.012 15.7 0.0 1.5 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_32 PF13679.6 EXF73671.1 - 0.007 16.4 0.0 0.011 15.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.18 EXF73671.1 - 0.033 13.9 0.0 0.13 12.0 0.0 1.8 1 1 0 1 1 1 0 Putative RNA methylase family UPF0020 Methyltransf_11 PF08241.12 EXF73671.1 - 0.038 14.6 0.0 0.079 13.6 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Met_10 PF02475.16 EXF73671.1 - 0.041 13.6 0.0 0.061 13.1 0.0 1.2 1 0 0 1 1 1 0 Met-10+ like-protein Ubie_methyltran PF01209.18 EXF73671.1 - 0.077 12.3 0.0 0.11 11.8 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Cons_hypoth95 PF03602.15 EXF73671.1 - 0.083 12.5 0.0 0.14 11.8 0.0 1.2 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Methyltransf_12 PF08242.12 EXF73671.1 - 0.16 12.7 0.0 0.28 11.9 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain DUF2722 PF10846.8 EXF73673.1 - 0.011 14.7 3.6 0.021 13.8 3.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Spt20 PF12090.8 EXF73673.1 - 0.43 10.2 3.9 0.87 9.2 3.9 1.4 1 0 0 1 1 1 0 Spt20 family AA_permease PF00324.21 EXF73674.1 - 1.2e-64 218.7 31.4 1.5e-64 218.4 31.4 1.1 1 0 0 1 1 1 1 Amino acid permease SLC12 PF03522.15 EXF73674.1 - 2.9e-24 85.9 2.0 5e-09 35.7 0.0 3.3 3 0 0 3 3 3 3 Solute carrier family 12 AA_permease_2 PF13520.6 EXF73674.1 - 1.6e-17 63.5 36.2 3.6e-17 62.3 36.2 1.5 1 1 0 1 1 1 1 Amino acid permease FXR_C1 PF16096.5 EXF73674.1 - 0.048 13.9 0.2 0.13 12.4 0.2 1.7 1 0 0 1 1 1 0 Fragile X-related 1 protein C-terminal region 2 Aa_trans PF01490.18 EXF73675.1 - 4.2e-83 279.3 30.7 5.5e-83 279.0 30.7 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein RNA_pol_L_2 PF13656.6 EXF73675.1 - 1.2e-22 79.4 0.3 2.1e-22 78.7 0.3 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 EXF73675.1 - 2e-05 23.9 0.1 8.3e-05 21.9 0.1 2.0 1 1 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain LSM PF01423.22 EXF73676.1 - 1e-18 66.8 0.2 1.5e-18 66.3 0.2 1.3 1 0 0 1 1 1 1 LSM domain DNA_pol_A_exo1 PF01612.20 EXF73677.1 - 7.2e-16 58.4 0.0 1.1e-15 57.8 0.0 1.2 1 0 0 1 1 1 1 3'-5' exonuclease SMI1_KNR4 PF09346.10 EXF73678.1 - 8.3e-32 110.4 0.0 1.9e-31 109.2 0.0 1.6 1 1 0 1 1 1 1 SMI1 / KNR4 family (SUKH-1) UPF0220 PF05255.11 EXF73680.1 - 2.1e-67 225.8 4.8 2.4e-67 225.6 4.8 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0220) DUF3169 PF11368.8 EXF73680.1 - 0.58 9.6 3.7 0.2 11.1 1.2 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3169) Pkinase PF00069.25 EXF73681.1 - 2.3e-64 217.3 0.0 2.8e-64 217.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF73681.1 - 3.5e-25 88.8 0.0 4.5e-25 88.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EXF73681.1 - 2.1e-06 27.3 0.0 9.9e-06 25.1 0.0 1.9 1 1 1 2 2 2 1 Kinase-like APH PF01636.23 EXF73681.1 - 0.0031 17.5 0.1 0.014 15.3 0.0 1.9 2 1 1 3 3 3 1 Phosphotransferase enzyme family DUF1229 PF06797.11 EXF73681.1 - 0.006 16.8 0.2 0.0095 16.2 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1229) Kdo PF06293.14 EXF73681.1 - 0.1 11.9 0.0 0.18 11.1 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 EXF73681.1 - 0.14 11.7 0.0 0.25 10.9 0.0 1.5 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 MIF4G_like PF09088.11 EXF73682.1 - 3.2e-91 304.3 0.1 4.9e-91 303.7 0.1 1.3 1 0 0 1 1 1 1 MIF4G like MIF4G_like_2 PF09090.11 EXF73682.1 - 4e-74 249.5 0.0 7e-74 248.7 0.0 1.4 1 0 0 1 1 1 1 MIF4G like Tape_meas_lam_C PF09718.10 EXF73682.1 - 0.11 12.6 0.7 0.4 10.8 0.1 2.1 2 0 0 2 2 2 0 Lambda phage tail tape-measure protein (Tape_meas_lam_C) WD40 PF00400.32 EXF73683.1 - 4.8e-22 77.8 10.6 5e-08 33.5 0.1 7.2 7 0 0 7 7 7 4 WD domain, G-beta repeat NLE PF08154.12 EXF73683.1 - 3e-15 56.5 0.2 6.6e-15 55.4 0.2 1.6 1 0 0 1 1 1 1 NLE (NUC135) domain Nup160 PF11715.8 EXF73683.1 - 3.2e-06 26.1 2.6 0.0008 18.2 1.0 2.9 2 1 1 3 3 3 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 EXF73683.1 - 0.18 10.7 0.2 0.69 8.8 0.0 1.9 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Sec8_exocyst PF04048.14 EXF73684.1 - 7.2e-48 162.1 0.8 3.2e-47 160.0 0.2 2.4 3 0 0 3 3 3 1 Sec8 exocyst complex component specific domain Vps54_N PF10475.9 EXF73684.1 - 7.9e-09 35.2 0.5 1.5e-08 34.3 0.5 1.4 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex Zincin_2 PF10103.9 EXF73684.1 - 0.1 11.9 0.0 3.3 6.9 0.0 2.3 2 0 0 2 2 2 0 Zincin-like metallopeptidase RAI1 PF08652.11 EXF73685.1 - 8e-29 99.6 0.1 2.3e-28 98.2 0.0 1.8 2 0 0 2 2 2 1 RAI1 like PD-(D/E)XK nuclease Pkinase PF00069.25 EXF73686.1 - 7.5e-69 232.0 0.0 1.1e-68 231.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF73686.1 - 3.5e-48 164.1 0.0 5.7e-48 163.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EXF73686.1 - 4.7e-06 26.1 0.0 6.9e-05 22.3 0.0 2.2 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 EXF73686.1 - 1.6e-05 23.9 0.0 3.7e-05 22.7 0.0 1.6 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 EXF73686.1 - 0.035 13.0 0.0 0.079 11.9 0.0 1.5 1 1 0 1 1 1 0 Haspin like kinase domain Transglut_core PF01841.19 EXF73687.1 - 1.9e-10 41.2 0.3 6.3e-10 39.5 0.3 1.9 1 0 0 1 1 1 1 Transglutaminase-like superfamily SH3_2 PF07653.17 EXF73687.1 - 9.2e-09 34.9 0.3 2e-08 33.8 0.3 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EXF73687.1 - 0.00013 21.5 2.3 0.00013 21.4 0.2 2.2 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 EXF73687.1 - 0.021 14.7 0.3 0.043 13.7 0.3 1.6 1 0 0 1 1 1 0 Variant SH3 domain Sec2p PF06428.11 EXF73687.1 - 9.5 6.3 7.8 1.4 8.9 2.1 2.2 2 0 0 2 2 2 0 GDP/GTP exchange factor Sec2p DUF410 PF04190.13 EXF73688.1 - 4.8e-93 311.6 0.0 5.6e-93 311.4 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF410) Pro_dh PF01619.18 EXF73689.1 - 4.4e-61 207.0 0.0 5.1e-61 206.8 0.0 1.0 1 0 0 1 1 1 1 Proline dehydrogenase DUF269 PF03270.13 EXF73689.1 - 0.1 12.7 0.0 0.2 11.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF269 Aldedh PF00171.22 EXF73690.1 - 2.4e-106 356.0 0.0 2.9e-106 355.8 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Fungal_trans PF04082.18 EXF73691.1 - 3.2e-21 75.6 0.1 5.2e-21 74.9 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF73691.1 - 0.00042 20.4 12.0 0.0011 19.0 9.3 2.3 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Aminotran_5 PF00266.19 EXF73692.1 - 2e-34 119.2 0.0 2e-23 82.9 0.0 2.0 1 1 1 2 2 2 2 Aminotransferase class-V adh_short PF00106.25 EXF73693.1 - 6.4e-21 74.7 0.0 1e-20 74.0 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF73693.1 - 1.2e-16 61.0 0.0 1.9e-16 60.4 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF1776 PF08643.10 EXF73693.1 - 0.18 11.1 0.0 0.27 10.6 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) SNRNP27 PF08648.12 EXF73694.1 - 3.8e-28 97.3 1.5 7.7e-28 96.3 1.5 1.5 1 0 0 1 1 1 1 U4/U6.U5 small nuclear ribonucleoproteins Elong_Iki1 PF10483.9 EXF73695.1 - 2.9e-106 355.3 0.0 3.3e-106 355.1 0.0 1.0 1 0 0 1 1 1 1 Elongator subunit Iki1 NACHT PF05729.12 EXF73695.1 - 0.19 11.7 0.9 0.85 9.5 1.0 1.9 1 1 0 1 1 1 0 NACHT domain ASXH PF13919.6 EXF73696.1 - 3.6e-38 130.7 0.1 9.1e-38 129.4 0.1 1.6 1 0 0 1 1 1 1 Asx homology domain Longin PF13774.6 EXF73697.1 - 7.3e-20 70.8 0.1 4.7e-19 68.2 0.1 2.1 1 1 0 1 1 1 1 Regulated-SNARE-like domain Synaptobrevin PF00957.21 EXF73697.1 - 9.5e-16 57.4 0.0 1.4e-14 53.7 0.0 2.1 2 0 0 2 2 2 1 Synaptobrevin DUF5435 PF17503.2 EXF73697.1 - 0.023 14.5 0.0 0.032 14.0 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5435) DUF4404 PF14357.6 EXF73697.1 - 0.075 13.7 1.9 4.8 7.9 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) SIMPL PF04402.14 EXF73697.1 - 0.25 11.8 3.8 0.73 10.3 3.8 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF541) DUF1664 PF07889.12 EXF73697.1 - 1.7 8.7 5.7 0.98 9.5 0.1 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) CLPTM1 PF05602.12 EXF73699.1 - 2.5e-152 507.9 0.0 3e-152 507.6 0.0 1.1 1 0 0 1 1 1 1 Cleft lip and palate transmembrane protein 1 (CLPTM1) DUF1772 PF08592.11 EXF73699.1 - 0.25 11.6 2.1 2.3 8.6 0.6 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF1772) Lysine_decarbox PF03641.14 EXF73700.1 - 3.8e-30 104.7 0.0 5.8e-30 104.1 0.0 1.3 1 0 0 1 1 1 1 Possible lysine decarboxylase LDcluster4 PF18306.1 EXF73700.1 - 1.4e-06 28.0 0.9 7.6e-06 25.6 0.9 2.1 1 1 0 1 1 1 1 SLOG cluster4 family DAGK_cat PF00781.24 EXF73700.1 - 0.18 11.5 1.5 2.9 7.5 0.1 2.6 3 0 0 3 3 3 0 Diacylglycerol kinase catalytic domain Proteasome PF00227.26 EXF73701.1 - 2.8e-49 167.2 0.2 3.5e-49 166.9 0.2 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EXF73701.1 - 4.8e-11 42.1 0.2 7.8e-11 41.4 0.2 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Vps55 PF04133.14 EXF73702.1 - 2.3e-46 156.5 6.2 2.6e-46 156.3 6.2 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting 55 Chorismate_bind PF00425.18 EXF73703.1 - 2.1e-67 227.4 0.0 4.4e-66 223.1 0.0 2.3 1 1 0 1 1 1 1 chorismate binding enzyme GATase PF00117.28 EXF73703.1 - 4.9e-25 88.4 0.0 2.1e-24 86.4 0.0 1.9 1 1 0 1 1 1 1 Glutamine amidotransferase class-I Anth_synt_I_N PF04715.13 EXF73703.1 - 1.8e-12 47.7 0.0 9.4e-12 45.3 0.0 2.1 2 0 0 2 2 2 1 Anthranilate synthase component I, N terminal region Peptidase_C26 PF07722.13 EXF73703.1 - 8.2e-05 22.5 0.4 0.00048 20.0 0.4 2.0 1 1 0 1 1 1 1 Peptidase C26 TRAPPC9-Trs120 PF08626.11 EXF73704.1 - 0 1373.8 0.0 0 1373.5 0.0 1.1 1 0 0 1 1 1 1 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit Edc3_linker PF16598.5 EXF73704.1 - 0.052 14.2 2.0 0.15 12.8 2.0 1.8 1 0 0 1 1 1 0 Linker region of enhancer of mRNA-decapping protein 3 AvrD PF05655.11 EXF73704.1 - 0.15 11.4 0.3 0.32 10.3 0.3 1.4 1 0 0 1 1 1 0 Pseudomonas avirulence D protein (AvrD) Glyco_hydro_63 PF03200.16 EXF73705.1 - 1.6e-170 568.1 0.3 2.2e-169 564.3 0.3 2.2 1 1 0 1 1 1 1 Glycosyl hydrolase family 63 C-terminal domain Glyco_hydro_63N PF16923.5 EXF73705.1 - 1.4e-80 270.6 1.0 2.6e-80 269.8 0.2 1.8 2 0 0 2 2 2 1 Glycosyl hydrolase family 63 N-terminal domain Trehalase PF01204.18 EXF73705.1 - 9.2e-09 34.7 0.0 1.8e-08 33.7 0.0 1.4 1 0 0 1 1 1 1 Trehalase TrmE_N PF10396.9 EXF73708.1 - 5.5e-35 120.2 0.0 1.2e-34 119.0 0.0 1.6 1 0 0 1 1 1 1 GTP-binding protein TrmE N-terminus MnmE_helical PF12631.7 EXF73708.1 - 6.2e-32 111.5 0.1 8.3e-32 111.0 0.1 1.2 1 0 0 1 1 1 1 MnmE helical domain MMR_HSR1 PF01926.23 EXF73708.1 - 3.3e-17 62.6 0.0 6e-17 61.8 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EXF73708.1 - 5.3e-05 22.8 0.0 0.00014 21.5 0.0 1.6 2 0 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EXF73708.1 - 0.001 19.2 0.1 0.0023 18.0 0.0 1.6 2 0 0 2 2 2 1 Dynamin family RsgA_GTPase PF03193.16 EXF73708.1 - 0.01 15.8 0.0 0.17 11.8 0.0 2.4 2 0 0 2 2 2 0 RsgA GTPase AAA_24 PF13479.6 EXF73708.1 - 0.037 13.8 0.0 0.07 12.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain Ribosomal_L28e PF01778.17 EXF73709.1 - 9.8e-38 129.4 0.9 2e-37 128.4 0.9 1.5 1 0 0 1 1 1 1 Ribosomal L28e protein family Mak16 PF04874.14 EXF73709.1 - 1.2e-29 102.8 15.2 1.2e-29 102.8 15.2 2.5 2 1 0 2 2 2 1 Mak16 protein C-terminal region BUD22 PF09073.10 EXF73709.1 - 1.7e-06 27.7 21.1 2.2e-06 27.3 21.1 1.1 1 0 0 1 1 1 1 BUD22 TFIIF_alpha PF05793.12 EXF73709.1 - 0.0084 14.7 31.0 0.011 14.4 31.0 1.2 1 0 0 1 1 1 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) PYC_OADA PF02436.18 EXF73709.1 - 0.24 11.1 3.0 0.36 10.6 2.5 1.6 1 1 0 1 1 1 0 Conserved carboxylase domain Rgp1 PF08737.10 EXF73709.1 - 5.1 6.2 6.6 6.4 5.8 6.6 1.2 1 0 0 1 1 1 0 Rgp1 Drc1-Sld2 PF11719.8 EXF73709.1 - 6.7 6.1 27.3 11 5.4 27.1 1.4 1 1 0 1 1 1 0 DNA replication and checkpoint protein RabGAP-TBC PF00566.18 EXF73710.1 - 3.2e-37 128.3 3.2 8e-37 127.0 3.2 1.7 1 1 0 1 1 1 1 Rab-GTPase-TBC domain PH_RBD PF12068.8 EXF73710.1 - 4e-08 32.9 0.0 0.0016 17.9 0.0 3.1 3 0 0 3 3 3 2 Rab-binding domain (RBD) HET PF06985.11 EXF73712.1 - 1.8e-24 86.7 0.0 3.9e-24 85.7 0.0 1.6 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) UPF0029 PF01205.19 EXF73713.1 - 5.3e-33 113.5 0.0 8e-33 112.9 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 RWD PF05773.22 EXF73713.1 - 2.5e-06 27.7 0.0 1e-05 25.8 0.0 2.0 1 1 0 1 1 1 1 RWD domain ACT_7 PF13840.6 EXF73714.1 - 9.2e-23 79.8 0.4 6.2e-20 70.8 0.1 2.4 2 0 0 2 2 2 2 ACT domain Methyltransf_32 PF13679.6 EXF73717.1 - 2.3e-20 73.2 0.0 4.4e-20 72.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Syntaxin-6_N PF09177.11 EXF73718.1 - 3.1e-25 88.6 0.0 8.8e-25 87.2 0.0 1.7 2 0 0 2 2 2 1 Syntaxin 6, N-terminal SNARE PF05739.19 EXF73718.1 - 0.0026 17.7 0.4 0.0049 16.8 0.4 1.5 1 0 0 1 1 1 1 SNARE domain TBCA PF02970.16 EXF73718.1 - 0.13 12.6 1.4 0.57 10.5 0.2 2.5 3 1 0 3 3 3 0 Tubulin binding cofactor A GCIP PF13324.6 EXF73718.1 - 0.22 11.1 4.4 0.32 10.6 3.7 1.7 1 1 0 1 1 1 0 Grap2 and cyclin-D-interacting ATG16 PF08614.11 EXF73718.1 - 0.35 11.1 5.3 1.2 9.3 0.4 2.4 2 1 0 2 2 2 0 Autophagy protein 16 (ATG16) Pox_EPC_I2-L1 PF12575.8 EXF73718.1 - 1.2 9.4 3.3 66 3.8 1.3 3.0 3 0 0 3 3 3 0 Poxvirus entry protein complex L1 and I2 GLE1 PF07817.13 EXF73719.1 - 2.4e-63 213.7 0.0 4.2e-63 212.9 0.0 1.4 1 0 0 1 1 1 1 GLE1-like protein YabA PF06156.13 EXF73719.1 - 0.94 10.1 3.3 1.9 9.2 1.3 2.3 2 1 0 2 2 2 0 Initiation control protein YabA DUF1640 PF07798.11 EXF73719.1 - 6 6.9 9.0 1.1e+02 2.8 8.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1640) RNB PF00773.19 EXF73721.1 - 2.1e-81 273.8 0.0 3.6e-81 273.0 0.0 1.4 1 0 0 1 1 1 1 RNB domain OB_Dis3 PF17849.1 EXF73721.1 - 9e-26 89.7 0.0 2.4e-25 88.3 0.0 1.8 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) Dis3l2_C_term PF17877.1 EXF73721.1 - 9.2e-26 90.0 0.0 3.2e-25 88.3 0.0 2.0 1 0 0 1 1 1 1 DIS3-like exonuclease 2 C terminal CSD2 PF17876.1 EXF73721.1 - 3.6e-06 27.0 0.0 0.017 15.3 0.0 2.7 2 0 0 2 2 2 2 Cold shock domain Rrp44_CSD1 PF17216.3 EXF73721.1 - 0.0043 16.8 0.0 0.0043 16.8 0.0 1.7 2 0 0 2 2 2 1 Rrp44-like cold shock domain DUF4239 PF14023.6 EXF73721.1 - 0.027 14.2 0.5 0.056 13.2 0.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4239) Ferritin_2 PF13668.6 EXF73722.1 - 4e-40 137.2 0.7 5.7e-40 136.7 0.7 1.2 1 0 0 1 1 1 1 Ferritin-like domain FAD_binding_3 PF01494.19 EXF73723.1 - 1.3e-42 146.3 0.0 1.9e-42 145.8 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 EXF73723.1 - 9.5e-07 29.0 0.1 2.1e-06 27.9 0.1 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EXF73723.1 - 1e-05 25.3 0.0 0.00013 21.7 0.1 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EXF73723.1 - 3.1e-05 23.3 0.0 0.0001 21.7 0.0 1.7 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EXF73723.1 - 9.2e-05 22.9 0.0 0.00037 21.0 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EXF73723.1 - 0.00051 18.9 0.0 0.00082 18.2 0.0 1.3 1 0 0 1 1 1 1 HI0933-like protein Lycopene_cycl PF05834.12 EXF73723.1 - 0.00095 18.3 0.0 0.0016 17.6 0.0 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein Thi4 PF01946.17 EXF73723.1 - 0.0019 17.5 0.0 0.0034 16.7 0.0 1.3 1 0 0 1 1 1 1 Thi4 family Pyr_redox_3 PF13738.6 EXF73723.1 - 0.0026 17.0 0.1 0.005 16.1 0.1 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EXF73723.1 - 0.0042 16.2 0.0 0.0063 15.7 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Amino_oxidase PF01593.24 EXF73723.1 - 0.019 14.3 0.0 3.2 6.9 0.0 2.7 3 0 0 3 3 3 0 Flavin containing amine oxidoreductase Trp_halogenase PF04820.14 EXF73723.1 - 0.067 12.0 0.0 0.23 10.3 0.0 1.7 2 0 0 2 2 2 0 Tryptophan halogenase NAD_binding_9 PF13454.6 EXF73723.1 - 0.09 12.8 0.1 0.17 11.9 0.1 1.4 1 0 0 1 1 1 0 FAD-NAD(P)-binding ApbA PF02558.16 EXF73723.1 - 0.11 12.2 0.0 0.18 11.4 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA FAD_oxidored PF12831.7 EXF73723.1 - 0.15 11.4 0.0 0.3 10.4 0.0 1.5 1 1 0 1 1 1 0 FAD dependent oxidoreductase GIDA PF01134.22 EXF73723.1 - 0.26 10.3 0.0 0.37 9.8 0.0 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A DUF3433 PF11915.8 EXF73724.1 - 1.6e-42 143.9 14.0 1.4e-25 89.5 1.1 3.4 3 0 0 3 3 3 2 Protein of unknown function (DUF3433) Glyco_hydro_61 PF03443.14 EXF73725.1 - 0.0018 18.3 0.2 0.0036 17.3 0.2 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 PT PF04886.12 EXF73725.1 - 7.2 6.2 23.0 5.3 6.7 10.9 2.7 2 0 0 2 2 2 0 PT repeat GGACT PF06094.12 EXF73726.1 - 4.7e-17 62.7 0.1 6.5e-17 62.3 0.1 1.2 1 0 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like FAT PF02259.23 EXF73727.1 - 4.5e-71 239.9 6.2 1.3e-70 238.4 6.2 1.9 1 0 0 1 1 1 1 FAT domain PI3_PI4_kinase PF00454.27 EXF73727.1 - 3.3e-35 122.1 0.1 9.1e-35 120.7 0.1 1.9 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.20 EXF73727.1 - 3.9e-07 29.8 0.2 1.1e-06 28.3 0.2 1.9 1 0 0 1 1 1 1 FATC domain TPR_2 PF07719.17 EXF73727.1 - 0.041 14.0 2.2 5.4 7.4 0.2 3.2 2 0 0 2 2 2 0 Tetratricopeptide repeat HEAT_EZ PF13513.6 EXF73727.1 - 0.042 14.4 0.2 19 5.9 0.0 5.1 5 0 0 5 5 5 0 HEAT-like repeat AAA_32 PF13654.6 EXF73727.1 - 0.081 11.7 1.6 0.24 10.1 0.0 2.5 3 0 0 3 3 3 0 AAA domain TPR_8 PF13181.6 EXF73727.1 - 0.19 12.0 4.4 0.22 11.8 0.4 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat Urb2 PF10441.9 EXF73727.1 - 0.45 10.4 8.0 3.2 7.6 0.0 5.3 6 0 0 6 6 6 0 Urb2/Npa2 family TPR_1 PF00515.28 EXF73727.1 - 3.2 7.7 6.9 21 5.2 0.2 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat Aminotran_1_2 PF00155.21 EXF73728.1 - 1.7e-07 30.7 0.0 2.3e-05 23.7 0.0 2.3 2 0 0 2 2 2 2 Aminotransferase class I and II Ribosomal_L4 PF00573.22 EXF73729.1 - 1.5e-32 112.8 0.7 2.1e-32 112.4 0.7 1.2 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Ribos_L4_asso_C PF14374.6 EXF73729.1 - 1.1e-26 92.7 1.8 1.1e-26 92.7 1.8 1.8 2 0 0 2 2 2 1 60S ribosomal protein L4 C-terminal domain AA_permease_2 PF13520.6 EXF73730.1 - 1.1e-42 146.3 36.1 1.5e-42 145.9 36.1 1.2 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EXF73730.1 - 7.5e-23 80.9 35.8 1.3e-21 76.8 35.7 2.1 1 1 0 1 1 1 1 Amino acid permease ZZ PF00569.17 EXF73731.1 - 6.3 6.7 5.7 3.1 7.7 0.9 2.5 3 0 0 3 3 3 0 Zinc finger, ZZ type Glyco_hydro_76 PF03663.14 EXF73732.1 - 5.5e-157 523.0 15.8 6.3e-157 522.8 15.8 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 EXF73732.1 - 0.00022 20.4 7.1 0.099 11.7 0.1 3.1 3 0 0 3 3 3 2 Glycosyl Hydrolase Family 88 Dak1 PF02733.17 EXF73733.1 - 7.4e-104 347.0 6.3 1e-103 346.5 6.3 1.2 1 0 0 1 1 1 1 Dak1 domain Dak2 PF02734.17 EXF73733.1 - 2.5e-47 161.0 0.7 2.5e-47 161.0 0.7 1.9 2 0 0 2 2 2 1 DAK2 domain LRV PF01816.17 EXF73733.1 - 0.065 13.7 0.1 0.26 11.7 0.1 2.1 1 0 0 1 1 1 0 Leucine rich repeat variant LSM PF01423.22 EXF73734.1 - 6.5e-18 64.2 0.1 9.1e-18 63.7 0.1 1.2 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 EXF73734.1 - 0.12 12.0 0.0 0.22 11.2 0.0 1.3 1 0 0 1 1 1 0 Hfq protein ECH_2 PF16113.5 EXF73735.1 - 4.9e-127 424.0 0.0 7.9e-127 423.3 0.0 1.3 2 0 0 2 2 2 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 EXF73735.1 - 6.8e-31 107.5 0.0 5.5e-26 91.4 0.0 2.2 2 0 0 2 2 2 2 Enoyl-CoA hydratase/isomerase WHEP-TRS PF00458.20 EXF73735.1 - 0.66 10.2 3.2 8.5 6.6 0.1 2.4 2 0 0 2 2 2 0 WHEP-TRS domain GATA PF00320.27 EXF73736.1 - 0.053 13.1 9.1 0.11 12.1 1.8 2.5 2 0 0 2 2 2 0 GATA zinc finger PAP_assoc PF03828.19 EXF73737.1 - 2.5e-12 46.8 0.0 4.5e-12 46.0 0.0 1.4 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 EXF73737.1 - 3.2e-05 24.1 0.0 7.5e-05 23.0 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyltransferase domain DAD PF02109.16 EXF73737.1 - 0.12 12.7 0.2 0.27 11.5 0.0 1.6 2 0 0 2 2 2 0 DAD family Sugar_tr PF00083.24 EXF73738.1 - 9e-110 367.6 18.8 1.2e-109 367.2 18.8 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF73738.1 - 1.8e-21 76.5 23.3 1.8e-21 76.5 23.3 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily MFS_3 PF05977.13 EXF73738.1 - 0.15 10.4 5.6 0.3 9.4 5.6 1.4 1 0 0 1 1 1 0 Transmembrane secretion effector SMI1_KNR4 PF09346.10 EXF73739.1 - 0.00085 19.7 0.0 0.0025 18.2 0.0 1.8 1 0 0 1 1 1 1 SMI1 / KNR4 family (SUKH-1) WSC PF01822.19 EXF73740.1 - 9.6e-15 54.6 9.3 1.9e-14 53.6 9.3 1.5 1 0 0 1 1 1 1 WSC domain DUF4834 PF16118.5 EXF73740.1 - 0.22 12.5 0.1 0.63 11.0 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Glyco_hydro_43 PF04616.14 EXF73742.1 - 9.1e-57 192.6 4.5 1.9e-56 191.5 4.5 1.5 1 1 0 1 1 1 1 Glycosyl hydrolases family 43 GH43_C2 PF17851.1 EXF73742.1 - 6.3e-10 39.1 0.0 9.7e-10 38.5 0.0 1.2 1 0 0 1 1 1 1 Beta xylosidase C-terminal Concanavalin A-like domain Glyco_hydro_43 PF04616.14 EXF73743.1 - 1.1e-27 97.1 8.3 2.1e-27 96.2 4.2 2.6 2 1 0 2 2 2 1 Glycosyl hydrolases family 43 GH43_C2 PF17851.1 EXF73743.1 - 3.9e-23 82.2 0.0 5.6e-23 81.7 0.0 1.2 1 0 0 1 1 1 1 Beta xylosidase C-terminal Concanavalin A-like domain CBM_10 PF02013.16 EXF73743.1 - 0.26 11.8 1.7 1.3 9.5 1.7 2.2 1 0 0 1 1 1 0 Cellulose or protein binding domain NAD_binding_10 PF13460.6 EXF73745.1 - 1.5e-13 51.1 0.0 2.6e-13 50.3 0.0 1.4 1 1 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EXF73745.1 - 4.1e-06 26.5 0.0 5.6e-06 26.1 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family Semialdhyde_dh PF01118.24 EXF73745.1 - 0.00096 19.6 0.0 0.0015 18.9 0.0 1.3 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain MFS_1 PF07690.16 EXF73746.1 - 3.6e-22 78.8 66.8 3.2e-13 49.3 34.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EXF73746.1 - 0.00018 20.2 13.6 0.00018 20.2 13.6 2.5 3 0 0 3 3 3 2 MFS/sugar transport protein MFS_1 PF07690.16 EXF73747.1 - 4.8e-36 124.4 29.3 4.8e-36 124.4 29.3 1.3 2 0 0 2 2 2 1 Major Facilitator Superfamily SpoVAB PF13782.6 EXF73747.1 - 0.015 15.6 0.8 0.015 15.6 0.8 2.5 3 0 0 3 3 3 0 Stage V sporulation protein AB Phage_holin_2_4 PF16082.5 EXF73747.1 - 0.18 11.6 6.3 0.44 10.3 0.3 2.8 2 1 0 2 2 2 0 Bacteriophage holin family, superfamily II-like CBM_4_9 PF02018.17 EXF73749.1 - 0.00045 20.5 0.0 0.0009 19.5 0.0 1.5 1 1 0 1 1 1 1 Carbohydrate binding domain Peptidase_M43 PF05572.13 EXF73750.1 - 2.7e-11 43.6 0.0 5.8e-11 42.5 0.0 1.5 1 0 0 1 1 1 1 Pregnancy-associated plasma protein-A Reprolysin_5 PF13688.6 EXF73750.1 - 5.6e-05 23.4 0.1 0.00016 21.9 0.1 1.6 1 1 0 1 1 1 1 Metallo-peptidase family M12 Peptidase_M10 PF00413.24 EXF73750.1 - 0.012 15.5 0.0 0.018 14.9 0.0 1.2 1 0 0 1 1 1 0 Matrixin Astacin PF01400.24 EXF73750.1 - 0.015 14.9 0.0 0.025 14.2 0.0 1.3 1 0 0 1 1 1 0 Astacin (Peptidase family M12A) Reprolysin_3 PF13582.6 EXF73750.1 - 0.018 15.6 0.1 0.028 14.9 0.1 1.5 1 1 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 EXF73750.1 - 0.069 12.8 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like RGS PF00615.19 EXF73751.1 - 4.2e-05 23.8 0.0 0.00043 20.6 0.0 2.1 2 0 0 2 2 2 1 Regulator of G protein signaling domain Abhydrolase_6 PF12697.7 EXF73752.1 - 1.7e-07 32.1 1.4 4.2e-06 27.5 1.4 2.2 1 1 0 1 1 1 1 Alpha/beta hydrolase family FbpA PF05833.11 EXF73753.1 - 0.001 17.9 1.5 0.0014 17.5 1.5 1.2 1 0 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) Activator-TraM PF11657.8 EXF73753.1 - 0.048 13.5 11.1 0.088 12.6 11.1 1.4 1 0 0 1 1 1 0 Transcriptional activator TraM GlutR_dimer PF00745.20 EXF73753.1 - 0.16 12.4 10.5 0.18 12.2 5.5 2.4 1 1 1 2 2 2 0 Glutamyl-tRNAGlu reductase, dimerisation domain TFIIA PF03153.13 EXF73753.1 - 0.29 11.1 9.9 0.37 10.7 9.9 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit UPF0242 PF06785.11 EXF73753.1 - 0.31 11.1 4.3 0.6 10.2 4.3 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Herpes_UL3 PF03369.13 EXF73753.1 - 0.39 11.3 2.7 1.4 9.4 1.5 2.1 2 0 0 2 2 2 0 Herpesvirus UL3 protein DUF1690 PF07956.11 EXF73753.1 - 0.59 10.6 5.1 1 9.8 5.1 1.4 1 0 0 1 1 1 0 Protein of Unknown function (DUF1690) 3HCDH_N PF02737.18 EXF73753.1 - 1.1 9.1 9.5 0.089 12.7 1.1 2.3 1 1 1 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain XendoU PF09412.10 EXF73753.1 - 3.2 6.9 6.3 21 4.2 7.0 1.8 1 1 1 2 2 2 0 Endoribonuclease XendoU MFS_1 PF07690.16 EXF73754.1 - 2.2e-34 118.9 57.9 1.3e-28 100.0 34.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily HSP70 PF00012.20 EXF73755.1 - 0.13 10.4 7.0 0.14 10.3 7.0 1.0 1 0 0 1 1 1 0 Hsp70 protein TMPIT PF07851.13 EXF73755.1 - 1.7 7.8 4.6 2 7.6 4.6 1.0 1 0 0 1 1 1 0 TMPIT-like protein VIR_N PF15912.5 EXF73755.1 - 3.9 7.0 7.9 5.2 6.6 7.9 1.1 1 0 0 1 1 1 0 Virilizer, N-terminal FUSC PF04632.12 EXF73755.1 - 9.8 4.6 6.3 12 4.2 6.3 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF2834 PF11196.8 EXF73756.1 - 2.4 8.6 7.4 0.22 11.9 0.9 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF2834) DivIC PF04977.15 EXF73758.1 - 0.0044 16.8 3.8 0.0044 16.8 3.8 2.2 2 0 0 2 2 2 1 Septum formation initiator DUF3450 PF11932.8 EXF73758.1 - 0.023 14.0 3.6 0.023 14.0 3.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) SlyX PF04102.12 EXF73758.1 - 0.059 14.0 1.7 0.059 14.0 1.7 2.5 2 1 0 2 2 2 0 SlyX TraC PF07820.12 EXF73758.1 - 0.1 13.0 4.1 5.2 7.5 0.0 3.0 3 1 0 3 3 3 0 TraC-like protein Syntaxin-6_N PF09177.11 EXF73758.1 - 0.15 12.7 2.5 2.3 8.8 0.1 2.3 2 0 0 2 2 2 0 Syntaxin 6, N-terminal DUF5446 PF17522.2 EXF73758.1 - 0.32 11.2 1.8 6.8 6.9 0.5 2.5 2 2 0 2 2 2 0 Family of unknown function (DUF5446) BRE1 PF08647.11 EXF73758.1 - 0.42 10.7 7.8 0.13 12.4 2.3 2.2 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase Med9 PF07544.13 EXF73758.1 - 1 9.5 6.8 3.2 7.9 2.2 3.0 3 0 0 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 Fib_alpha PF08702.10 EXF73758.1 - 5.6 7.1 8.1 9.9 6.3 0.8 2.6 1 1 1 3 3 3 0 Fibrinogen alpha/beta chain family Uso1_p115_C PF04871.13 EXF73761.1 - 0.015 15.7 8.5 0.015 15.7 8.5 1.7 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region FtsK_gamma PF09397.10 EXF73761.1 - 0.031 14.1 0.0 0.071 12.9 0.0 1.6 1 0 0 1 1 1 0 Ftsk gamma domain Mto2_bdg PF12808.7 EXF73761.1 - 0.033 14.5 4.4 0.12 12.7 0.8 2.8 2 1 1 3 3 3 0 Micro-tubular organiser Mto1 C-term Mto2-binding region GLE1 PF07817.13 EXF73761.1 - 0.043 13.0 1.0 0.067 12.4 1.0 1.4 1 1 0 1 1 1 0 GLE1-like protein Shugoshin_N PF07558.11 EXF73761.1 - 0.078 12.9 1.3 0.24 11.3 1.3 1.9 1 0 0 1 1 1 0 Shugoshin N-terminal coiled-coil region Fez1 PF06818.15 EXF73761.1 - 0.11 12.9 8.0 0.12 12.8 7.3 1.3 1 1 0 1 1 1 0 Fez1 NYD-SP28_assoc PF14775.6 EXF73761.1 - 0.17 12.0 2.2 0.4 10.8 2.1 1.8 1 1 0 1 1 1 0 Sperm tail C-terminal domain DUF5385 PF17359.2 EXF73761.1 - 0.2 11.2 7.4 0.26 10.8 7.4 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5385) Ntox15 PF15604.6 EXF73761.1 - 0.36 10.9 7.2 0.055 13.6 1.3 1.9 1 1 1 2 2 2 0 Novel toxin 15 Phlebovirus_NSM PF07246.11 EXF73761.1 - 0.42 9.9 8.0 0.34 10.3 7.0 1.3 1 1 0 1 1 1 0 Phlebovirus nonstructural protein NS-M MetOD2 PF18548.1 EXF73761.1 - 0.5 10.5 6.3 0.63 10.2 0.5 2.3 1 1 1 2 2 2 0 Metanogen output domain 2 YabA PF06156.13 EXF73761.1 - 5.6 7.7 8.9 6.4 7.5 4.1 2.6 1 1 0 2 2 2 0 Initiation control protein YabA DivIC PF04977.15 EXF73761.1 - 5.7 6.8 9.7 0.21 11.4 1.4 2.5 2 1 1 3 3 3 0 Septum formation initiator MIP PF00230.20 EXF73762.1 - 5.8e-48 163.6 15.0 7e-48 163.3 15.0 1.0 1 0 0 1 1 1 1 Major intrinsic protein Sec61_beta PF03911.16 EXF73762.1 - 0.06 13.4 1.0 14 5.8 0.0 2.9 2 0 0 2 2 2 0 Sec61beta family AMP-binding PF00501.28 EXF73763.1 - 4.9e-63 213.2 0.0 6.9e-63 212.7 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EXF73763.1 - 8.1e-10 39.6 0.3 2.2e-09 38.2 0.3 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain DIOX_N PF14226.6 EXF73764.1 - 4.3e-23 82.3 0.0 6.3e-23 81.8 0.0 1.2 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal DUF3450 PF11932.8 EXF73765.1 - 0.0029 17.0 0.3 0.0045 16.3 0.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3450) FTA4 PF13093.6 EXF73765.1 - 0.0043 17.0 1.6 0.037 13.9 0.6 2.0 1 1 1 2 2 2 1 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 PI3K_P85_iSH2 PF16454.5 EXF73765.1 - 0.0086 15.7 0.9 0.01 15.4 0.2 1.6 2 0 0 2 2 2 1 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain ABC_tran_CTD PF16326.5 EXF73765.1 - 0.11 12.7 0.8 0.89 9.8 0.2 2.3 1 1 1 2 2 2 0 ABC transporter C-terminal domain Arm-DNA-bind_2 PF12167.8 EXF73765.1 - 0.33 10.9 0.1 0.33 10.9 0.1 1.9 3 0 0 3 3 3 0 Arm DNA-binding domain XhlA PF10779.9 EXF73765.1 - 1.6 8.9 7.2 19 5.5 0.4 3.3 2 1 0 3 3 3 0 Haemolysin XhlA DUF4200 PF13863.6 EXF73765.1 - 3 8.3 7.8 1.6 9.1 3.7 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) MTTB PF06253.11 EXF73766.1 - 0.087 10.8 5.1 0.14 10.2 5.1 1.3 1 1 0 1 1 1 0 Trimethylamine methyltransferase (MTTB) Ank_2 PF12796.7 EXF73767.1 - 3.9e-13 49.8 2.7 0.012 16.1 0.0 7.1 5 1 1 6 6 6 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EXF73767.1 - 3.9e-12 46.4 0.0 0.34 11.5 0.0 6.7 6 1 1 7 7 7 4 Ankyrin repeats (many copies) Ank PF00023.30 EXF73767.1 - 1.7e-08 34.5 0.8 33 5.2 0.0 7.7 7 0 0 7 7 7 0 Ankyrin repeat Ank_5 PF13857.6 EXF73767.1 - 3.8e-08 33.4 1.5 6.1 7.3 0.0 6.8 7 0 0 7 7 7 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EXF73767.1 - 3.2e-07 30.1 5.6 5.1 8.0 0.0 8.8 10 1 0 10 10 10 1 Ankyrin repeat F-box-like PF12937.7 EXF73767.1 - 0.057 13.3 2.1 8.9 6.3 0.1 3.4 3 0 0 3 3 3 0 F-box-like Zn_clus PF00172.18 EXF73768.1 - 0.00035 20.6 2.3 0.00035 20.6 2.3 2.6 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EXF73768.1 - 0.003 16.4 0.3 0.028 13.2 0.3 2.0 1 1 0 1 1 1 1 Fungal specific transcription factor domain MFS_1 PF07690.16 EXF73769.1 - 1e-38 133.2 27.5 1e-38 133.2 27.5 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF3754 PF12576.8 EXF73769.1 - 8 6.4 7.9 1.1 9.2 0.1 3.2 2 2 1 3 3 3 0 Protein of unknown function (DUF3754) Cytochrom_B562 PF07361.11 EXF73770.1 - 0.13 12.9 3.9 1.4 9.6 3.8 2.2 2 0 0 2 2 2 0 Cytochrome b562 Herpes_UL6 PF01763.16 EXF73770.1 - 0.94 7.9 3.9 1.4 7.3 3.9 1.1 1 0 0 1 1 1 0 Herpesvirus UL6 like V_ATPase_I PF01496.19 EXF73770.1 - 2.9 5.7 3.9 4.1 5.2 3.5 1.4 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Shugoshin_N PF07558.11 EXF73771.1 - 0.075 12.9 1.2 0.16 11.9 1.2 1.5 1 0 0 1 1 1 0 Shugoshin N-terminal coiled-coil region Peptidase_Prp PF04327.12 EXF73772.1 - 0.13 12.5 0.4 0.7 10.2 0.0 2.1 2 0 0 2 2 2 0 Cysteine protease Prp Aminotran_1_2 PF00155.21 EXF73773.1 - 5.9e-51 173.8 0.0 7.2e-51 173.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_3 PF00202.21 EXF73773.1 - 0.19 10.4 0.0 0.28 9.8 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class-III p450 PF00067.22 EXF73774.1 - 5.9e-35 120.9 0.0 6.9e-35 120.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 ApbA_C PF08546.11 EXF73774.1 - 0.014 15.6 0.0 0.026 14.7 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA C terminal AAA_23 PF13476.6 EXF73775.1 - 2.9 8.4 10.7 0.45 11.0 1.1 2.6 2 0 0 2 2 2 0 AAA domain Tri3 PF07428.11 EXF73776.1 - 0.00067 18.7 1.2 0.0047 15.9 1.2 2.1 1 1 0 1 1 1 1 15-O-acetyltransferase Tri3 AA_permease PF00324.21 EXF73777.1 - 5.8e-148 493.5 36.9 6.6e-148 493.2 36.9 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EXF73777.1 - 1.8e-40 139.1 41.9 3.1e-40 138.3 41.9 1.3 1 0 0 1 1 1 1 Amino acid permease Ank_2 PF12796.7 EXF73778.1 - 3.1e-59 197.5 0.0 1.1e-12 48.3 0.0 7.7 3 2 6 9 9 9 8 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EXF73778.1 - 4e-37 126.1 1.5 4.9e-08 33.4 0.0 9.9 7 3 1 9 9 9 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EXF73778.1 - 2.3e-35 116.6 0.4 0.0024 18.2 0.0 12.9 13 0 0 13 13 13 9 Ankyrin repeat Ank_5 PF13857.6 EXF73778.1 - 2.2e-30 104.3 0.1 1.3e-06 28.5 0.0 10.1 6 4 5 11 11 11 7 Ankyrin repeats (many copies) Ank PF00023.30 EXF73778.1 - 9.1e-25 86.0 7.6 0.00025 21.4 0.0 12.3 14 1 0 14 14 14 6 Ankyrin repeat SPRY PF00622.28 EXF73778.1 - 1.5e-06 28.4 0.6 4.2e-05 23.7 0.0 2.4 2 0 0 2 2 2 1 SPRY domain UCH PF00443.29 EXF73778.1 - 0.035 13.6 0.0 0.086 12.3 0.0 1.6 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase Peptidase_M35 PF02102.15 EXF73779.1 - 0.022 13.6 4.3 0.032 13.1 4.3 1.1 1 0 0 1 1 1 0 Deuterolysin metalloprotease (M35) family AAA PF00004.29 EXF73780.1 - 5.6e-13 49.5 0.0 4.5e-12 46.5 0.0 2.5 3 1 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EXF73780.1 - 2.2e-05 24.9 0.0 4.2e-05 24.0 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EXF73780.1 - 0.00076 19.8 0.6 0.004 17.4 0.6 2.2 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 EXF73780.1 - 0.0023 17.9 0.0 0.0048 16.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 EXF73780.1 - 0.0037 17.0 0.0 0.0071 16.1 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain IstB_IS21 PF01695.17 EXF73780.1 - 0.11 12.3 0.0 0.19 11.4 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_33 PF13671.6 EXF73780.1 - 0.12 12.5 0.0 0.23 11.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 EXF73780.1 - 0.22 10.7 0.0 0.48 9.5 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain GREB1 PF15782.5 EXF73782.1 - 8.1 3.4 9.6 9.1 3.2 9.6 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer LPMO_10 PF03067.15 EXF73783.1 - 2e-09 38.4 0.7 4e-09 37.4 0.7 1.5 1 1 0 1 1 1 1 Lytic polysaccharide mono-oxygenase, cellulose-degrading Fungal_trans PF04082.18 EXF73784.1 - 1.2e-21 77.0 0.0 2e-21 76.2 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF73784.1 - 1.1e-05 25.4 11.4 2.2e-05 24.5 11.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PAN_4 PF14295.6 EXF73785.1 - 0.024 14.5 3.3 0.14 12.1 0.5 2.6 2 0 0 2 2 2 0 PAN domain Sugar_tr PF00083.24 EXF73786.1 - 5.8e-117 391.3 21.4 2e-115 386.3 21.4 2.0 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF73786.1 - 9.7e-25 87.2 44.3 2.9e-17 62.6 16.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily BT1 PF03092.16 EXF73786.1 - 0.0012 17.2 1.0 0.0012 17.2 1.0 1.9 2 0 0 2 2 2 1 BT1 family THF_DHG_CYH PF00763.23 EXF73787.1 - 4.9e-21 75.2 0.0 8.5e-21 74.4 0.0 1.4 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain THF_DHG_CYH_C PF02882.19 EXF73787.1 - 0.00019 20.8 0.3 0.00027 20.3 0.3 1.2 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain ABC2_membrane PF01061.24 EXF73788.1 - 9.2e-79 263.7 55.2 8.5e-42 142.9 18.4 3.3 4 0 0 4 4 3 2 ABC-2 type transporter ABC_tran PF00005.27 EXF73788.1 - 9.9e-39 133.0 0.0 9.3e-21 74.8 0.0 2.7 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.12 EXF73788.1 - 4.7e-30 103.3 6.5 1.5e-25 88.9 0.0 3.9 3 0 0 3 3 3 2 CDR ABC transporter ABC_trans_N PF14510.6 EXF73788.1 - 2.6e-11 44.0 0.0 1e-10 42.1 0.0 2.1 2 0 0 2 2 1 1 ABC-transporter N-terminal ABC2_membrane_3 PF12698.7 EXF73788.1 - 2.9e-10 39.8 37.8 1.3e-08 34.3 7.7 2.6 3 0 0 3 3 2 2 ABC-2 family transporter protein AAA_22 PF13401.6 EXF73788.1 - 1.8e-06 28.3 0.1 0.069 13.4 0.1 3.1 3 0 0 3 3 3 2 AAA domain AAA_16 PF13191.6 EXF73788.1 - 1.9e-06 28.3 0.1 0.017 15.5 0.1 2.6 2 0 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 EXF73788.1 - 1.3e-05 25.2 0.1 0.00043 20.2 0.1 2.3 2 0 0 2 2 2 1 RsgA GTPase AAA_29 PF13555.6 EXF73788.1 - 5.8e-05 22.8 0.5 0.36 10.6 0.2 2.9 2 0 0 2 2 2 2 P-loop containing region of AAA domain cobW PF02492.19 EXF73788.1 - 0.00014 21.5 0.4 0.0023 17.5 0.5 2.3 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_18 PF13238.6 EXF73788.1 - 0.00017 22.2 0.0 0.037 14.6 0.0 2.7 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 EXF73788.1 - 0.00048 20.2 0.0 0.25 11.4 0.1 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_28 PF13521.6 EXF73788.1 - 0.00085 19.6 0.0 0.052 13.8 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_21 PF13304.6 EXF73788.1 - 0.0016 18.3 0.0 0.41 10.4 0.0 2.9 4 0 0 4 4 2 1 AAA domain, putative AbiEii toxin, Type IV TA system NACHT PF05729.12 EXF73788.1 - 0.002 18.0 0.3 0.32 10.9 0.4 2.5 2 0 0 2 2 2 1 NACHT domain SMC_N PF02463.19 EXF73788.1 - 0.0026 17.2 0.1 0.43 10.0 0.0 3.2 3 1 0 3 3 3 1 RecF/RecN/SMC N terminal domain AAA_33 PF13671.6 EXF73788.1 - 0.0028 17.8 1.0 0.18 11.9 0.0 2.8 3 0 0 3 3 2 1 AAA domain AAA_19 PF13245.6 EXF73788.1 - 0.0036 17.6 0.2 4.6 7.6 0.3 2.6 2 0 0 2 2 2 1 AAA domain NB-ARC PF00931.22 EXF73788.1 - 0.0043 16.3 0.2 1.5 7.9 0.2 2.3 2 0 0 2 2 2 1 NB-ARC domain RecA PF00154.21 EXF73788.1 - 0.005 16.3 0.1 0.0098 15.4 0.1 1.4 1 0 0 1 1 1 1 recA bacterial DNA recombination protein AAA PF00004.29 EXF73788.1 - 0.011 16.2 0.0 3.4 8.1 0.0 2.9 3 0 0 3 3 2 0 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 EXF73788.1 - 0.013 15.2 0.4 2.7 7.6 0.3 2.4 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 EXF73788.1 - 0.019 15.0 0.3 0.2 11.6 0.3 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DnaB_C PF03796.15 EXF73788.1 - 0.023 14.0 0.0 2.6 7.3 0.0 2.2 2 0 0 2 2 2 0 DnaB-like helicase C terminal domain Ploopntkinase3 PF18751.1 EXF73788.1 - 0.026 14.5 0.0 5.1 7.0 0.0 2.3 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 AAA_17 PF13207.6 EXF73788.1 - 0.03 14.7 0.0 0.64 10.5 0.0 2.6 2 0 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 EXF73788.1 - 0.037 13.9 0.0 11 5.8 0.0 2.4 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_24 PF13479.6 EXF73788.1 - 0.038 13.7 0.1 0.24 11.1 0.1 2.3 3 0 0 3 3 2 0 AAA domain Zeta_toxin PF06414.12 EXF73788.1 - 0.05 12.9 0.2 0.71 9.1 0.3 2.2 2 0 0 2 2 2 0 Zeta toxin PduV-EutP PF10662.9 EXF73788.1 - 0.093 12.5 0.3 1.2 8.8 0.4 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_25 PF13481.6 EXF73788.1 - 0.16 11.5 0.0 3.7 7.1 0.1 2.8 3 0 0 3 3 3 0 AAA domain NTPase_1 PF03266.15 EXF73788.1 - 0.19 11.6 0.1 11 5.8 0.1 2.9 3 0 0 3 3 3 0 NTPase FtsK_SpoIIIE PF01580.18 EXF73788.1 - 0.2 11.0 0.7 8.6 5.6 0.0 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family T2SSE PF00437.20 EXF73788.1 - 0.22 10.6 0.1 5.6 5.9 0.1 2.2 2 0 0 2 2 2 0 Type II/IV secretion system protein DUF4291 PF14124.6 EXF73789.1 - 1.2e-64 217.5 0.0 1.9e-64 216.9 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4291) Git3 PF11710.8 EXF73789.1 - 5.3e-17 62.3 8.7 1.1e-16 61.2 8.7 1.6 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 7tm_1 PF00001.21 EXF73789.1 - 1.5e-05 24.5 8.5 2.9e-05 23.5 8.5 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) LptF_LptG PF03739.14 EXF73789.1 - 0.059 12.2 0.1 0.059 12.2 0.1 2.5 2 0 0 2 2 2 0 Lipopolysaccharide export system permease LptF/LptG GPR_Gpa2_C PF11970.8 EXF73789.1 - 0.085 12.9 0.0 0.34 11.0 0.0 2.0 1 0 0 1 1 1 0 G protein-coupled glucose receptor regulating Gpa2 C-term Dicty_CAR PF05462.11 EXF73789.1 - 0.12 11.5 11.4 0.073 12.2 7.9 2.1 2 0 0 2 2 2 0 Slime mold cyclic AMP receptor AMP-binding PF00501.28 EXF73790.1 - 3.7e-74 249.8 0.0 5.1e-74 249.4 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme NAD_binding_4 PF07993.12 EXF73790.1 - 9.1e-67 224.9 0.0 1.3e-66 224.4 0.0 1.2 1 0 0 1 1 1 1 Male sterility protein PP-binding PF00550.25 EXF73790.1 - 1.3e-10 41.5 0.0 4e-10 39.9 0.0 1.9 1 0 0 1 1 1 1 Phosphopantetheine attachment site Epimerase PF01370.21 EXF73790.1 - 1.2e-09 38.1 0.0 2.4e-09 37.0 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EXF73790.1 - 5.1e-08 32.3 0.0 1.2e-07 31.1 0.0 1.6 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family AMP-binding_C PF13193.6 EXF73790.1 - 0.00021 22.2 0.0 0.00064 20.7 0.0 2.0 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Polysacc_synt_2 PF02719.15 EXF73790.1 - 0.0022 17.2 0.0 0.011 14.9 0.0 1.9 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 EXF73790.1 - 0.095 11.8 0.3 0.52 9.4 0.3 2.2 1 1 0 1 1 1 0 RmlD substrate binding domain GDP_Man_Dehyd PF16363.5 EXF73790.1 - 0.15 11.4 0.0 0.25 10.7 0.0 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase MFS_1 PF07690.16 EXF73791.1 - 1.3e-14 54.0 48.6 1.7e-12 47.0 46.9 3.1 1 1 0 1 1 1 1 Major Facilitator Superfamily Peptidase_S8 PF00082.22 EXF73792.1 - 1.9e-34 119.3 0.1 2.9e-34 118.7 0.1 1.3 1 0 0 1 1 1 1 Subtilase family fn3_5 PF06280.12 EXF73792.1 - 3.6e-08 34.1 0.0 7.9e-08 33.0 0.0 1.6 1 0 0 1 1 1 1 Fn3-like domain DUF3632 PF12311.8 EXF73793.1 - 1.9e-33 116.4 0.2 2.9e-33 115.8 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3632) p450 PF00067.22 EXF73796.1 - 8.3e-54 183.1 0.0 1e-53 182.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Corona_S2 PF01601.16 EXF73797.1 - 3.5 6.0 4.3 1.4 7.3 1.5 1.6 1 1 1 2 2 2 0 Coronavirus S2 glycoprotein Methyltransf_32 PF13679.6 EXF73798.1 - 1.6e-24 86.7 0.1 2.7e-24 85.9 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF73798.1 - 4.9e-06 26.4 0.0 9.4e-06 25.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EXF73798.1 - 1.7e-05 24.4 0.0 3e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.6 EXF73798.1 - 0.00038 21.1 0.0 0.00091 19.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain GidB PF02527.15 EXF73798.1 - 0.00044 19.6 0.0 0.00074 18.9 0.0 1.3 1 0 0 1 1 1 1 rRNA small subunit methyltransferase G Methyltransf_12 PF08242.12 EXF73798.1 - 0.016 15.9 0.0 0.033 14.9 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain PrmA PF06325.13 EXF73798.1 - 0.021 14.2 0.0 0.033 13.6 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_4 PF02390.17 EXF73798.1 - 0.079 12.4 0.0 0.14 11.6 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase PCMT PF01135.19 EXF73798.1 - 0.082 12.7 0.0 0.13 12.0 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) SPATA48 PF15073.6 EXF73798.1 - 0.11 12.8 0.0 0.36 11.1 0.0 1.9 1 0 0 1 1 1 0 Spermatogenesis-associated protein 48 Methyltransf_11 PF08241.12 EXF73798.1 - 0.13 12.9 0.0 0.29 11.8 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_16 PF10294.9 EXF73798.1 - 0.16 11.7 0.0 0.27 11.0 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase Ank_2 PF12796.7 EXF73799.1 - 3.7e-57 190.9 6.7 5e-11 43.0 0.1 8.7 5 3 5 10 10 10 10 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EXF73799.1 - 1.2e-45 153.3 13.3 4.4e-06 27.1 0.0 14.1 7 3 6 13 13 13 10 Ankyrin repeats (many copies) Ank_3 PF13606.6 EXF73799.1 - 1e-37 123.8 7.9 0.0035 17.7 0.0 17.9 18 0 0 18 18 18 7 Ankyrin repeat Ank PF00023.30 EXF73799.1 - 4e-29 99.7 20.0 0.088 13.3 0.3 16.2 16 1 0 16 16 15 9 Ankyrin repeat NACHT_N PF17100.5 EXF73799.1 - 1.2e-28 100.5 1.1 2.1e-28 99.7 1.1 1.4 1 0 0 1 1 1 1 N-terminal domain of NWD NACHT-NTPase Ank_5 PF13857.6 EXF73799.1 - 8.3e-24 83.4 14.2 0.00073 19.8 0.1 11.7 10 3 3 13 13 13 4 Ankyrin repeats (many copies) NACHT PF05729.12 EXF73799.1 - 1.5e-13 51.0 0.0 5.4e-13 49.2 0.0 2.0 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 EXF73799.1 - 0.0019 18.6 0.0 0.021 15.2 0.0 2.6 2 0 0 2 2 2 1 AAA ATPase domain MAGE_N PF12440.8 EXF73799.1 - 0.29 11.8 8.7 0.74 10.5 8.7 1.6 1 0 0 1 1 1 0 Melanoma associated antigen family N terminal Filament PF00038.21 EXF73799.1 - 0.32 10.6 4.2 0.58 9.7 4.2 1.3 1 0 0 1 1 1 0 Intermediate filament protein DUF1843 PF08898.10 EXF73799.1 - 3.2 8.3 10.8 2 9.0 0.4 5.1 5 1 1 6 6 6 0 Domain of unknown function (DUF1843) Fungal_trans_2 PF11951.8 EXF73800.1 - 4.1e-09 35.7 0.0 5.4e-09 35.3 0.0 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF73800.1 - 4.3e-06 26.8 9.9 6.8e-06 26.1 9.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain p450 PF00067.22 EXF73801.1 - 2e-50 171.9 0.0 2.9e-50 171.4 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Glyco_hydro_10 PF00331.20 EXF73803.1 - 2.4e-100 335.8 0.0 2.8e-100 335.5 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 10 CBM_1 PF00734.18 EXF73803.1 - 7.9e-15 54.5 11.9 2.8e-14 52.8 11.9 2.1 1 0 0 1 1 1 1 Fungal cellulose binding domain Botulinum_HA-17 PF05588.11 EXF73803.1 - 1.3 9.1 3.8 6.5 6.9 0.5 2.3 1 1 0 2 2 2 0 Clostridium botulinum HA-17 domain ADH_N PF08240.12 EXF73804.1 - 7.6e-25 86.9 4.9 1.4e-24 86.0 4.9 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EXF73804.1 - 1.7e-20 73.3 0.0 2.8e-20 72.6 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EXF73804.1 - 8.4e-12 46.3 0.0 1.7e-11 45.3 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 EXF73804.1 - 0.0003 20.1 0.0 0.00044 19.6 0.0 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.19 EXF73804.1 - 0.00048 19.5 0.1 0.0008 18.8 0.1 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain CBM_10 PF02013.16 EXF73804.1 - 2.1 8.9 6.2 6.9 7.2 0.1 2.7 3 0 0 3 3 3 0 Cellulose or protein binding domain Peroxidase_2 PF01328.17 EXF73805.1 - 4.3e-42 144.8 0.0 5.5e-42 144.4 0.0 1.1 1 0 0 1 1 1 1 Peroxidase, family 2 CFEM PF05730.11 EXF73806.1 - 1.7e-11 44.0 9.9 2.7e-11 43.4 9.9 1.3 1 0 0 1 1 1 1 CFEM domain GMC_oxred_C PF05199.13 EXF73807.1 - 6.3e-28 98.1 0.0 1.1e-27 97.4 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_N PF00732.19 EXF73807.1 - 9.6e-24 84.3 0.0 1.1e-21 77.5 0.0 2.8 2 1 0 2 2 2 1 GMC oxidoreductase Pyr_redox_2 PF07992.14 EXF73807.1 - 0.00031 20.1 0.0 0.00086 18.6 0.0 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EXF73807.1 - 0.011 16.0 0.0 0.025 14.8 0.0 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 EXF73807.1 - 0.017 14.4 0.0 3.6 6.7 0.0 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EXF73807.1 - 0.025 13.6 0.0 0.035 13.1 0.0 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein FAD_binding_2 PF00890.24 EXF73807.1 - 0.17 10.9 0.6 0.27 10.3 0.6 1.3 1 0 0 1 1 1 0 FAD binding domain Glyco_hydro_3_C PF01915.22 EXF73808.1 - 4.8e-50 170.3 0.0 7.4e-50 169.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 EXF73808.1 - 4.5e-31 108.4 0.0 1.4e-30 106.8 0.0 1.7 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 EXF73808.1 - 4e-24 84.5 0.1 7.8e-24 83.6 0.1 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain NYD-SP28_assoc PF14775.6 EXF73809.1 - 0.023 14.8 0.0 0.042 14.0 0.0 1.3 1 0 0 1 1 1 0 Sperm tail C-terminal domain UbiA PF01040.18 EXF73810.1 - 2.9e-18 66.1 8.6 4.6e-18 65.4 8.6 1.3 1 0 0 1 1 1 1 UbiA prenyltransferase family Nuc_sug_transp PF04142.15 EXF73811.1 - 8.5e-11 41.6 6.6 3.1e-10 39.7 6.6 1.7 2 0 0 2 2 2 1 Nucleotide-sugar transporter NMN_transporter PF04973.12 EXF73811.1 - 0.0017 18.4 6.5 0.0017 18.4 6.5 1.7 2 0 0 2 2 2 1 Nicotinamide mononucleotide transporter ENOD93 PF03386.14 EXF73811.1 - 0.2 11.5 0.2 0.65 9.9 0.2 1.8 1 0 0 1 1 1 0 Early nodulin 93 ENOD93 protein VIT1 PF01988.19 EXF73812.1 - 0.69 9.7 5.5 1.6 8.6 4.2 2.4 1 1 1 2 2 2 0 VIT family Abhydrolase_3 PF07859.13 EXF73813.1 - 5.1e-41 140.9 0.0 9.1e-41 140.0 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 EXF73813.1 - 7.4e-08 31.7 0.8 3e-07 29.7 0.8 1.7 1 1 0 1 1 1 1 Carboxylesterase family Prok-RING_1 PF14446.6 EXF73814.1 - 0.0052 16.7 8.5 0.12 12.4 0.1 2.2 1 1 1 2 2 2 2 Prokaryotic RING finger family 1 PHD PF00628.29 EXF73814.1 - 0.014 15.2 8.5 0.027 14.3 3.1 2.2 2 0 0 2 2 2 0 PHD-finger C1_1 PF00130.22 EXF73814.1 - 0.22 11.4 11.4 11 6.0 11.4 2.2 1 1 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) DUF983 PF06170.12 EXF73814.1 - 0.36 11.2 3.0 11 6.5 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF983) Rhodanese_C PF12368.8 EXF73814.1 - 1.4 9.4 12.5 39 4.7 12.5 2.1 1 1 0 1 1 1 0 Rhodanase C-terminal Sgf11 PF08209.11 EXF73814.1 - 3.5 7.3 10.6 0.3 10.7 0.7 2.9 2 1 1 3 3 3 0 Sgf11 (transcriptional regulation protein) Lipase_GDSL_2 PF13472.6 EXF73815.1 - 1.4e-09 38.6 0.3 1.8e-09 38.2 0.3 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EXF73815.1 - 0.0045 17.0 0.0 0.0062 16.5 0.0 1.3 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase DUF3818 PF12825.7 EXF73816.1 - 1.2e-57 195.5 0.1 1.9e-54 185.0 0.1 2.1 1 1 0 1 1 1 1 Domain of unknown function in PX-proteins (DUF3818) PXB PF12828.7 EXF73816.1 - 2.8e-41 140.6 0.1 5e-41 139.7 0.1 1.4 1 0 0 1 1 1 1 PX-associated Cation_efflux PF01545.21 EXF73817.1 - 1.1e-15 57.9 8.8 1.4e-15 57.6 8.8 1.1 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 EXF73817.1 - 6.9e-09 35.7 1.3 1.5e-08 34.6 1.3 1.5 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter Pkinase PF00069.25 EXF73818.1 - 1.3e-21 77.2 0.0 4.1e-20 72.2 0.0 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF73818.1 - 9.7e-17 61.1 0.0 1.8e-15 57.0 0.0 2.7 2 1 0 2 2 2 1 Protein tyrosine kinase Imm63 PF15599.6 EXF73818.1 - 0.13 12.7 0.0 0.28 11.6 0.0 1.5 1 0 0 1 1 1 0 Immunity protein 63 Pox_ser-thr_kin PF05445.11 EXF73818.1 - 0.13 11.2 0.0 0.2 10.6 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase CorA PF01544.18 EXF73819.1 - 6.4e-06 25.7 10.0 1.6e-05 24.4 7.7 2.5 2 1 0 2 2 2 1 CorA-like Mg2+ transporter protein Orf78 PF06024.12 EXF73819.1 - 0.003 17.8 0.0 0.0072 16.6 0.0 1.6 1 0 0 1 1 1 1 Orf78 (ac78) DUF1772 PF08592.11 EXF73819.1 - 0.062 13.6 0.1 0.12 12.7 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1772) Goodbye PF17109.5 EXF73820.1 - 5.3e-15 55.9 2.2 9.2e-15 55.2 0.1 2.6 3 0 0 3 3 2 1 fungal STAND N-terminal Goodbye domain AAA_16 PF13191.6 EXF73820.1 - 0.00026 21.4 0.0 0.00026 21.4 0.0 4.2 6 0 0 6 6 5 1 AAA ATPase domain AAA_22 PF13401.6 EXF73820.1 - 0.00034 20.9 0.3 0.0065 16.7 0.0 3.3 3 0 0 3 3 2 1 AAA domain TPR_16 PF13432.6 EXF73820.1 - 0.00054 20.6 2.1 0.021 15.5 0.1 4.1 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 EXF73820.1 - 0.00085 19.0 4.7 0.072 12.9 0.3 4.1 4 0 0 4 4 3 1 Tetratricopeptide repeat AAA_26 PF13500.6 EXF73820.1 - 0.00088 19.2 0.6 0.0042 16.9 0.0 2.5 3 0 0 3 3 3 1 AAA domain ATPase_2 PF01637.18 EXF73820.1 - 0.0009 19.2 0.0 0.0029 17.6 0.0 1.9 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_28 PF13521.6 EXF73820.1 - 0.0014 18.9 0.1 0.0063 16.8 0.0 2.2 2 0 0 2 2 1 1 AAA domain TPR_2 PF07719.17 EXF73820.1 - 0.0015 18.5 12.4 0.02 15.0 0.4 5.2 6 0 0 6 6 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 EXF73820.1 - 0.0033 18.1 8.4 84 4.4 0.0 6.8 4 1 1 5 5 5 0 Tetratricopeptide repeat EH_Signature PF15611.6 EXF73820.1 - 0.0062 16.0 5.7 0.45 9.9 0.3 2.5 1 1 0 2 2 2 2 EH_Signature domain TPR_12 PF13424.6 EXF73820.1 - 0.0068 16.7 0.8 0.0068 16.7 0.8 4.1 5 1 0 5 5 4 1 Tetratricopeptide repeat DUF3135 PF11333.8 EXF73820.1 - 0.013 15.8 0.7 0.12 12.6 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3135) TPR_19 PF14559.6 EXF73820.1 - 0.02 15.4 14.1 0.2 12.2 0.2 5.0 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_17 PF13431.6 EXF73820.1 - 0.06 13.7 1.9 0.3 11.5 0.3 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat NACHT PF05729.12 EXF73820.1 - 0.084 12.8 0.0 0.33 10.8 0.0 2.1 2 0 0 2 2 2 0 NACHT domain YqhG PF11079.8 EXF73820.1 - 0.089 11.7 0.3 0.2 10.6 0.3 1.5 1 0 0 1 1 1 0 Bacterial protein YqhG of unknown function TPR_4 PF07721.14 EXF73820.1 - 0.14 12.8 0.9 1.4 9.8 0.9 2.9 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_7 PF13176.6 EXF73820.1 - 0.19 11.9 1.2 46 4.4 0.2 4.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TniB PF05621.11 EXF73820.1 - 0.21 11.0 1.7 0.53 9.7 0.3 2.4 3 0 0 3 3 3 0 Bacterial TniB protein TPR_8 PF13181.6 EXF73820.1 - 0.82 10.0 11.2 0.37 11.1 0.3 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_10 PF13374.6 EXF73820.1 - 3.8 7.5 8.0 1.1 9.3 0.2 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat Glyco_hydro_53 PF07745.13 EXF73821.1 - 1.4e-81 274.1 0.1 1.7e-81 273.9 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 53 LysM PF01476.20 EXF73822.1 - 4e-07 30.0 1.9 2.3 8.3 0.1 4.8 5 0 0 5 5 5 4 LysM domain HSDR_N_2 PF13588.6 EXF73822.1 - 3.4e-05 23.8 0.2 0.0091 16.0 0.0 2.5 3 0 0 3 3 3 2 Type I restriction enzyme R protein N terminus (HSDR_N) Slx4 PF09494.10 EXF73822.1 - 0.054 13.4 0.0 9.1 6.3 0.0 3.1 3 0 0 3 3 3 0 Slx4 endonuclease LysM PF01476.20 EXF73823.1 - 1.1e-14 54.2 0.9 7.5e-06 25.9 0.0 3.5 3 0 0 3 3 3 3 LysM domain Glyco_hydro_18 PF00704.28 EXF73824.1 - 1.2e-59 202.6 2.1 1.6e-59 202.2 2.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Chitin_bind_1 PF00187.19 EXF73824.1 - 5e-12 46.1 29.4 3.1e-10 40.4 5.5 4.4 5 0 0 5 5 5 2 Chitin recognition protein Glyco_hydro_85 PF03644.13 EXF73824.1 - 0.00064 19.2 0.2 0.0011 18.5 0.2 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 85 DUF4849 PF16141.5 EXF73824.1 - 0.087 12.1 0.1 0.14 11.4 0.1 1.2 1 0 0 1 1 1 0 Putative glycoside hydrolase Family 18, chitinase_18 Ank_4 PF13637.6 EXF73825.1 - 2e-30 104.8 2.3 2.4e-06 28.0 0.0 7.7 7 2 1 8 8 8 6 Ankyrin repeats (many copies) Ank_2 PF12796.7 EXF73825.1 - 9.9e-30 103.0 0.0 2.4e-08 34.4 0.1 6.9 3 2 2 6 6 6 5 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EXF73825.1 - 6.7e-22 77.3 6.0 1.6e-06 28.3 0.0 9.4 8 3 3 11 11 11 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EXF73825.1 - 1.8e-17 61.6 7.1 0.014 15.9 0.0 10.3 12 2 0 12 12 12 5 Ankyrin repeat Ank PF00023.30 EXF73825.1 - 1.9e-14 53.4 11.0 5.3 7.7 0.0 10.4 11 0 0 11 11 11 5 Ankyrin repeat HLH PF00010.26 EXF73826.1 - 1.9 8.5 5.3 0.63 10.0 0.1 2.6 2 0 0 2 2 2 0 Helix-loop-helix DNA-binding domain Glyco_hydro_88 PF07470.13 EXF73828.1 - 2.4e-67 227.4 6.1 3e-67 227.2 6.1 1.0 1 0 0 1 1 1 1 Glycosyl Hydrolase Family 88 Bcl-2 PF00452.19 EXF73828.1 - 0.05 14.3 0.1 0.13 13.0 0.1 1.7 1 0 0 1 1 1 0 Apoptosis regulator proteins, Bcl-2 family Aminotran_1_2 PF00155.21 EXF73829.1 - 3.4e-42 144.9 0.0 4.1e-42 144.7 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 EXF73829.1 - 0.01 15.2 0.0 0.015 14.6 0.0 1.3 1 0 0 1 1 1 0 Beta-eliminating lyase Hap4_Hap_bind PF10297.9 EXF73832.1 - 2.4e-07 30.6 6.7 9.5e-07 28.7 6.7 2.1 1 0 0 1 1 1 1 Minimal binding motif of Hap4 for binding to Hap2/3/5 bZIP_1 PF00170.21 EXF73832.1 - 5.6e-06 26.4 6.8 1.5e-05 25.0 6.8 1.8 1 1 0 1 1 1 1 bZIP transcription factor ISG65-75 PF11727.8 EXF73832.1 - 0.042 13.1 0.5 0.066 12.4 0.5 1.2 1 0 0 1 1 1 0 Invariant surface glycoprotein dsrm PF00035.26 EXF73832.1 - 0.055 14.2 0.1 0.37 11.5 0.0 2.4 2 0 0 2 2 2 0 Double-stranded RNA binding motif RBM39linker PF15519.6 EXF73832.1 - 0.37 11.9 0.0 0.37 11.9 0.0 4.3 3 2 1 4 4 4 0 linker between RRM2 and RRM3 domains in RBM39 protein TFIIA PF03153.13 EXF73832.1 - 7.7 6.4 25.8 2.9 7.8 16.8 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Hce2 PF14856.6 EXF73833.1 - 4.6e-17 62.2 0.4 8.4e-17 61.3 0.3 1.5 1 1 0 1 1 1 1 Pathogen effector; putative necrosis-inducing factor Hce2 PF14856.6 EXF73834.1 - 1.6e-11 44.4 0.8 3.2e-11 43.4 0.8 1.5 1 0 0 1 1 1 1 Pathogen effector; putative necrosis-inducing factor Defensin_3 PF08131.11 EXF73834.1 - 5 7.4 6.6 0.58 10.4 1.7 2.1 2 0 0 2 2 2 0 Defensin-like peptide family COesterase PF00135.28 EXF73835.1 - 1.3e-74 251.9 0.0 3.1e-73 247.4 0.0 2.3 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EXF73835.1 - 2.2e-07 30.9 0.1 8.4e-07 29.1 0.1 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EXF73835.1 - 0.023 14.2 0.4 0.056 12.9 0.4 1.6 1 0 0 1 1 1 0 Prolyl oligopeptidase family SesA PF17107.5 EXF73836.1 - 0.096 12.9 0.1 0.2 11.8 0.1 1.6 1 0 0 1 1 1 0 N-terminal domain on NACHT_NTPase and P-loop NTPases Pet191_N PF10203.9 EXF73836.1 - 1.7 9.0 4.8 8.5 6.8 4.0 2.4 2 0 0 2 2 2 0 Cytochrome c oxidase assembly protein PET191 CH PF00307.31 EXF73837.1 - 4e-13 49.5 0.0 7.7e-13 48.6 0.0 1.5 1 0 0 1 1 1 1 Calponin homology (CH) domain CDC24 PF06395.11 EXF73837.1 - 0.0063 16.7 0.0 0.013 15.8 0.0 1.4 1 0 0 1 1 1 1 CDC24 Calponin CAMSAP_CH PF11971.8 EXF73837.1 - 0.1 12.4 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 CAMSAP CH domain NDUFA12 PF05071.16 EXF73838.1 - 9.9e-10 39.1 0.1 9.9e-10 39.1 0.1 1.9 2 0 0 2 2 2 1 NADH ubiquinone oxidoreductase subunit NDUFA12 cwf21 PF08312.12 EXF73839.1 - 5.9e-17 61.5 11.8 5.9e-17 61.5 11.8 2.1 2 0 0 2 2 2 1 cwf21 domain GvpG PF05120.12 EXF73839.1 - 6.3 6.9 11.5 8.5 6.5 3.4 2.4 1 1 1 2 2 2 0 Gas vesicle protein G D123 PF07065.14 EXF73840.1 - 5.1e-116 387.1 0.0 6e-116 386.9 0.0 1.0 1 0 0 1 1 1 1 D123 DUF3716 PF12511.8 EXF73841.1 - 9.2e-17 60.8 9.7 1.4e-16 60.3 9.7 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3716) G-alpha PF00503.20 EXF73842.1 - 1.1e-124 416.1 2.5 1.3e-124 415.9 2.5 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EXF73842.1 - 3.1e-15 56.1 1.7 2.8e-10 39.9 0.1 2.5 2 0 0 2 2 2 2 ADP-ribosylation factor family zf-CHC2 PF01807.20 EXF73842.1 - 8.5e-05 22.3 0.0 0.00036 20.3 0.0 1.9 2 0 0 2 2 2 1 CHC2 zinc finger Gtr1_RagA PF04670.12 EXF73842.1 - 0.0019 17.6 2.9 0.11 11.9 0.0 2.7 2 1 1 3 3 3 2 Gtr1/RagA G protein conserved region AAA_29 PF13555.6 EXF73842.1 - 0.014 15.1 0.0 0.033 13.9 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain Roc PF08477.13 EXF73842.1 - 0.024 14.9 0.2 2.4 8.4 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase MCM PF00493.23 EXF73842.1 - 0.058 12.5 0.1 0.11 11.6 0.1 1.5 1 1 0 1 1 1 0 MCM P-loop domain GTP_EFTU PF00009.27 EXF73842.1 - 0.12 11.9 0.0 1.6 8.2 0.0 2.3 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain FtsK_SpoIIIE PF01580.18 EXF73842.1 - 0.12 11.7 0.0 0.28 10.5 0.0 1.6 1 0 0 1 1 1 0 FtsK/SpoIIIE family MMR_HSR1 PF01926.23 EXF73842.1 - 0.13 12.3 0.1 8.8 6.5 0.0 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase Omega-toxin PF06357.11 EXF73843.1 - 0.038 13.8 4.0 0.093 12.5 4.0 1.7 1 0 0 1 1 1 0 Omega-atracotoxin Thioredoxin PF00085.20 EXF73844.1 - 6.7e-23 80.6 0.5 7.4e-12 45.2 0.0 3.4 3 0 0 3 3 3 2 Thioredoxin Thioredoxin_6 PF13848.6 EXF73844.1 - 1.1e-21 77.6 0.5 8e-15 55.2 0.1 3.2 2 1 1 3 3 3 3 Thioredoxin-like domain Thioredoxin_2 PF13098.6 EXF73844.1 - 0.0018 18.7 0.3 0.081 13.4 0.0 3.0 2 1 0 2 2 2 1 Thioredoxin-like domain ERp29_N PF07912.13 EXF73844.1 - 0.011 15.8 0.0 10 6.3 0.0 3.0 3 0 0 3 3 3 0 ERp29, N-terminal domain Ank PF00023.30 EXF73845.1 - 0.044 14.3 0.0 4.2 8.0 0.0 2.3 2 0 0 2 2 2 0 Ankyrin repeat Ank_2 PF12796.7 EXF73845.1 - 0.098 13.3 0.0 0.16 12.6 0.0 1.4 1 1 0 1 1 1 0 Ankyrin repeats (3 copies) Ail_Lom PF06316.11 EXF73846.1 - 0.047 13.4 0.0 0.089 12.5 0.0 1.4 1 0 0 1 1 1 0 Enterobacterial Ail/Lom protein NAD_binding_8 PF13450.6 EXF73847.1 - 3.3e-07 30.4 0.0 8.9e-06 25.9 0.1 2.6 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EXF73847.1 - 2.5e-05 23.7 0.0 0.0087 15.3 0.0 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EXF73847.1 - 0.0016 18.5 0.4 0.12 12.4 0.0 2.9 3 0 0 3 3 3 1 FAD-NAD(P)-binding Shikimate_DH PF01488.20 EXF73847.1 - 0.0018 18.3 0.0 0.33 11.0 0.0 2.5 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase DAO PF01266.24 EXF73847.1 - 0.014 15.0 0.1 0.22 11.1 0.1 2.2 2 0 0 2 2 2 0 FAD dependent oxidoreductase F420_oxidored PF03807.17 EXF73847.1 - 0.073 13.7 0.1 1 10.0 0.2 2.6 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent ThiF PF00899.21 EXF73847.1 - 0.079 12.3 0.0 5 6.4 0.0 2.7 3 0 0 3 3 3 0 ThiF family 2-Hacid_dh_C PF02826.19 EXF73847.1 - 0.12 11.7 0.0 0.36 10.1 0.0 1.7 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyr_redox PF00070.27 EXF73847.1 - 0.44 11.1 1.4 15 6.2 0.0 3.4 4 0 0 4 4 4 0 Pyridine nucleotide-disulphide oxidoreductase DUF3328 PF11807.8 EXF73848.1 - 5.5e-05 23.0 2.3 9.4e-05 22.3 2.3 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF3328) ADH_zinc_N PF00107.26 EXF73850.1 - 4.2e-09 36.5 0.1 7e-09 35.7 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EXF73850.1 - 2.6e-06 27.3 0.0 5.1e-06 26.3 0.0 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Polyketide_cyc2 PF10604.9 EXF73851.1 - 1e-16 61.5 0.0 1.3e-16 61.2 0.0 1.0 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Bet_v_1 PF00407.19 EXF73851.1 - 0.035 14.0 0.0 0.049 13.5 0.0 1.2 1 0 0 1 1 1 0 Pathogenesis-related protein Bet v I family Carb_anhydrase PF00194.21 EXF73852.1 - 4e-34 118.3 0.1 5.6e-34 117.8 0.1 1.1 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase OTT_1508_deam PF14441.6 EXF73853.1 - 3.4e-16 59.0 2.4 1.5e-15 57.0 2.4 2.2 1 0 0 1 1 1 1 OTT_1508-like deaminase Peptidase_M49 PF03571.15 EXF73853.1 - 0.011 14.1 0.1 0.016 13.6 0.1 1.1 1 0 0 1 1 1 0 Peptidase family M49 HMG_box_5 PF14887.6 EXF73853.1 - 0.081 12.9 0.0 1.4 8.9 0.0 2.3 2 0 0 2 2 2 0 HMG (high mobility group) box 5 MFS_1 PF07690.16 EXF73854.1 - 1.8e-23 83.1 28.4 1.8e-23 83.1 28.4 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily DUF2627 PF11118.8 EXF73854.1 - 9.8 6.8 7.5 32 5.2 3.6 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2627) TauD PF02668.16 EXF73855.1 - 2.9e-44 151.9 0.4 4.6e-44 151.2 0.4 1.3 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family YebG PF07130.12 EXF73855.1 - 0.19 11.6 0.1 0.5 10.3 0.1 1.7 1 0 0 1 1 1 0 YebG protein Glyco_hydro_10 PF00331.20 EXF73857.1 - 2.6e-99 332.4 0.4 3.1e-99 332.1 0.4 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 10 Glyco_hydro_42 PF02449.15 EXF73857.1 - 0.11 11.8 0.1 0.27 10.5 0.1 1.4 1 1 0 1 1 1 0 Beta-galactosidase Sugar_tr PF00083.24 EXF73858.1 - 1.4e-123 413.2 28.9 1.6e-123 413.0 28.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF73858.1 - 1.5e-17 63.6 60.5 2.8e-15 56.1 38.9 2.6 1 1 2 3 3 3 3 Major Facilitator Superfamily Myb_DNA-binding PF00249.31 EXF73859.1 - 1.1e-21 76.8 8.2 5e-11 42.6 0.1 4.0 3 1 0 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EXF73859.1 - 2.9e-19 69.1 8.7 2.3e-09 37.4 0.1 4.0 3 1 0 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_4 PF13837.6 EXF73859.1 - 0.13 12.7 4.2 0.1 13.0 0.6 2.6 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain Amidohydro_1 PF01979.20 EXF73860.1 - 1.5e-25 90.2 0.0 2.7e-24 86.1 0.0 2.3 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EXF73860.1 - 1.4e-13 51.1 0.2 3.7e-07 30.0 0.0 2.2 2 0 0 2 2 2 2 Amidohydrolase family polyprenyl_synt PF00348.17 EXF73861.1 - 2.2e-74 249.8 0.0 3.4e-74 249.1 0.0 1.3 1 0 0 1 1 1 1 Polyprenyl synthetase HEPPP_synt_1 PF07307.11 EXF73861.1 - 0.018 14.6 0.0 0.03 14.0 0.0 1.2 1 0 0 1 1 1 0 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1 Vma12 PF11712.8 EXF73862.1 - 9.8e-45 152.0 0.0 1.6e-44 151.4 0.0 1.3 1 0 0 1 1 1 1 Endoplasmic reticulum-based factor for assembly of V-ATPase zf-C2H2_3 PF13878.6 EXF73862.1 - 2.7e-09 36.7 0.2 6.9e-09 35.4 0.1 1.8 2 0 0 2 2 2 1 zinc-finger of acetyl-transferase ESCO DUF1772 PF08592.11 EXF73862.1 - 0.087 13.1 0.4 0.16 12.2 0.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1772) Cutinase PF01083.22 EXF73863.1 - 4.1e-50 170.2 0.1 4.9e-50 170.0 0.1 1.1 1 0 0 1 1 1 1 Cutinase VirJ PF06057.11 EXF73863.1 - 0.0011 18.8 0.0 0.0015 18.4 0.0 1.1 1 0 0 1 1 1 1 Bacterial virulence protein (VirJ) Abhydrolase_2 PF02230.16 EXF73863.1 - 0.023 14.5 0.1 0.035 13.9 0.1 1.3 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase PE-PPE PF08237.11 EXF73863.1 - 0.068 12.7 0.1 0.094 12.3 0.1 1.2 1 0 0 1 1 1 0 PE-PPE domain adh_short_C2 PF13561.6 EXF73864.1 - 9.7e-61 205.3 1.5 1.1e-60 205.1 1.5 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF73864.1 - 1.5e-46 158.3 1.2 2e-46 157.9 1.2 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EXF73864.1 - 4.4e-12 46.3 0.9 6.6e-12 45.7 0.9 1.2 1 0 0 1 1 1 1 KR domain 3HCDH_N PF02737.18 EXF73864.1 - 7.7e-06 25.9 0.1 1.3e-05 25.2 0.1 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ADH_zinc_N PF00107.26 EXF73864.1 - 0.0001 22.3 0.8 0.0086 16.1 0.8 2.3 1 1 0 1 1 1 1 Zinc-binding dehydrogenase UDPG_MGDP_dh_N PF03721.14 EXF73864.1 - 0.025 14.1 0.2 0.054 13.1 0.1 1.6 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Fungal_trans_2 PF11951.8 EXF73865.1 - 2.9e-45 154.8 0.4 3.9e-45 154.3 0.4 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF73865.1 - 8.8e-07 28.9 5.5 1.7e-06 28.0 5.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain AA_permease PF00324.21 EXF73866.1 - 4.7e-109 365.1 46.5 6e-109 364.8 46.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EXF73866.1 - 5.9e-23 81.4 50.5 7.7e-23 81.0 50.5 1.0 1 0 0 1 1 1 1 Amino acid permease FMO-like PF00743.19 EXF73867.1 - 1.3e-20 73.3 0.2 2.3e-19 69.3 0.0 2.2 2 1 0 2 2 2 1 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.6 EXF73867.1 - 2.8e-11 43.5 0.0 4.6e-08 33.2 0.0 2.8 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 EXF73867.1 - 1.1e-07 31.4 0.0 3.7e-05 23.0 0.0 3.0 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.14 EXF73867.1 - 3.3e-07 29.8 0.0 8.7e-05 21.9 0.0 2.8 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EXF73867.1 - 6.5e-07 28.9 0.0 2.9e-05 23.5 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EXF73867.1 - 2e-05 23.9 0.0 0.016 14.4 0.0 2.9 3 0 0 3 3 3 2 Thi4 family DAO PF01266.24 EXF73867.1 - 0.00011 21.9 0.0 0.069 12.7 0.0 3.5 2 1 0 3 3 3 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EXF73867.1 - 0.00035 20.6 0.0 0.2 11.7 0.0 3.4 4 0 0 4 4 4 1 FAD-NAD(P)-binding 2-Hacid_dh_C PF02826.19 EXF73867.1 - 0.0062 15.9 0.0 0.012 15.0 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 EXF73867.1 - 0.0087 16.1 0.0 0.054 13.6 0.0 2.2 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase Semialdhyde_dh PF01118.24 EXF73867.1 - 0.02 15.3 0.0 0.12 12.8 0.0 2.3 3 0 0 3 3 3 0 Semialdehyde dehydrogenase, NAD binding domain FAD_binding_2 PF00890.24 EXF73867.1 - 0.045 12.8 0.0 0.071 12.2 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain Lycopene_cycl PF05834.12 EXF73867.1 - 0.07 12.2 0.0 0.12 11.4 0.0 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein adh_short_C2 PF13561.6 EXF73868.1 - 3.2e-62 210.1 3.2 5e-62 209.5 3.2 1.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF73868.1 - 1.1e-47 162.0 2.1 2e-47 161.2 2.1 1.3 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EXF73868.1 - 9.9e-11 41.9 0.8 4.4e-10 39.8 0.8 1.9 1 1 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EXF73868.1 - 1.4e-06 27.7 0.3 3.4e-06 26.4 0.1 1.7 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein Epimerase PF01370.21 EXF73868.1 - 0.00031 20.3 0.9 0.00075 19.0 0.9 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EXF73868.1 - 0.1 11.6 0.1 0.18 10.8 0.1 1.6 1 1 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family MFS_1 PF07690.16 EXF73869.1 - 5.3e-40 137.4 47.5 5.3e-40 137.4 47.5 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF73869.1 - 0.00042 19.3 20.1 0.00042 19.3 20.1 2.7 2 1 0 2 2 2 1 Sugar (and other) transporter DUF1269 PF06897.12 EXF73869.1 - 0.074 13.3 0.4 0.64 10.3 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1269) Glyco_hydro_31 PF01055.26 EXF73870.1 - 4.1e-112 375.6 4.5 6.2e-112 375.0 4.5 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 EXF73870.1 - 0.0001 22.6 0.7 0.00056 20.2 0.1 2.5 2 1 0 2 2 2 1 Galactose mutarotase-like GMC_oxred_N PF00732.19 EXF73871.1 - 2.1e-64 217.7 0.2 3.3e-64 217.1 0.1 1.4 2 0 0 2 2 2 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EXF73871.1 - 1.2e-33 116.6 0.3 2.4e-33 115.7 0.3 1.5 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.24 EXF73871.1 - 4.2e-07 29.4 0.0 0.0013 17.9 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain Pyr_redox_2 PF07992.14 EXF73871.1 - 0.00021 20.6 1.7 0.055 12.7 0.1 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EXF73871.1 - 0.0015 18.2 0.7 0.05 13.2 0.0 2.3 2 1 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EXF73871.1 - 0.0015 18.7 0.1 0.0045 17.2 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 EXF73871.1 - 0.0017 17.5 0.0 0.0029 16.7 0.0 1.4 1 0 0 1 1 1 1 Lycopene cyclase protein Thi4 PF01946.17 EXF73871.1 - 0.016 14.4 1.4 0.029 13.6 0.1 1.9 2 0 0 2 2 2 0 Thi4 family Pyr_redox PF00070.27 EXF73871.1 - 0.032 14.8 1.1 0.87 10.2 0.1 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EXF73871.1 - 0.045 13.0 0.0 4.3 6.5 0.0 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.18 EXF73871.1 - 0.09 13.0 0.6 0.3 11.4 0.1 2.0 2 0 0 2 2 2 0 TrkA-N domain PAP2 PF01569.21 EXF73873.1 - 6.3e-24 84.3 3.9 6.3e-24 84.3 3.9 1.8 2 0 0 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.6 EXF73873.1 - 0.0047 16.6 5.9 0.032 13.9 5.3 2.2 1 1 0 1 1 1 1 PAP2 superfamily DUF4231 PF14015.6 EXF73873.1 - 7.9 7.0 8.0 0.21 12.1 0.5 2.2 3 0 0 3 3 3 0 Protein of unknown function (DUF4231) Cutinase PF01083.22 EXF73874.1 - 2.8e-24 86.1 0.9 4.4e-24 85.4 0.9 1.3 1 0 0 1 1 1 1 Cutinase Glyco_hydro_79C PF16862.5 EXF73875.1 - 6e-19 68.8 3.7 1.2e-18 67.9 0.7 2.4 2 0 0 2 2 2 1 Glycosyl hydrolase family 79 C-terminal beta domain Pectate_lyase PF03211.13 EXF73876.1 - 4.8e-79 264.6 8.1 5.4e-79 264.5 8.1 1.0 1 0 0 1 1 1 1 Pectate lyase DUF4870 PF09685.10 EXF73877.1 - 3 8.0 10.5 0.22 11.6 3.6 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4870) DUF1815 PF08844.10 EXF73878.1 - 0.1 12.6 0.1 1 9.3 0.0 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF1815) FAD_binding_3 PF01494.19 EXF73879.1 - 4.9e-09 35.9 1.9 1.8e-05 24.2 0.2 2.9 2 1 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 EXF73879.1 - 7.9e-06 26.0 0.1 3.1e-05 24.1 0.0 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EXF73879.1 - 1.9e-05 24.0 0.0 3.2e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EXF73879.1 - 0.00014 21.3 0.2 0.00077 18.8 0.1 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EXF73879.1 - 0.00027 20.6 0.0 0.003 17.2 0.0 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 EXF73879.1 - 0.0011 19.4 0.0 0.07 13.7 0.1 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EXF73879.1 - 0.0029 16.4 0.0 0.0047 15.7 0.0 1.3 1 0 0 1 1 1 1 HI0933-like protein GIDA PF01134.22 EXF73879.1 - 0.011 14.8 0.0 0.016 14.3 0.0 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A FAD_oxidored PF12831.7 EXF73879.1 - 0.026 13.9 0.0 0.042 13.2 0.0 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EXF73879.1 - 0.068 12.4 0.0 0.19 11.0 0.0 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Sugar_tr PF00083.24 EXF73880.1 - 1.5e-68 231.7 19.2 1.7e-68 231.5 19.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF73880.1 - 1.2e-16 60.6 16.7 1.2e-16 60.6 16.7 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily Methyltransf_24 PF13578.6 EXF73882.1 - 6.2e-15 56.1 0.0 1e-14 55.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_3 PF01596.17 EXF73882.1 - 1.1e-08 34.6 0.0 1.6e-08 34.0 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_25 PF13649.6 EXF73882.1 - 0.16 12.7 0.0 0.28 11.9 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Abhydrolase_1 PF00561.20 EXF73884.1 - 6.3e-14 52.2 0.0 1.2e-13 51.3 0.0 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EXF73884.1 - 7.8e-11 43.0 0.0 9.8e-11 42.7 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EXF73884.1 - 3e-09 36.5 0.0 4.3e-09 36.0 0.0 1.4 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.13 EXF73884.1 - 0.019 14.9 0.0 0.029 14.2 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Thioesterase PF00975.20 EXF73884.1 - 0.024 14.8 0.0 0.034 14.3 0.0 1.4 1 0 0 1 1 1 0 Thioesterase domain Esterase PF00756.20 EXF73884.1 - 0.03 14.0 0.0 0.041 13.5 0.0 1.3 1 0 0 1 1 1 0 Putative esterase DUF2048 PF09752.9 EXF73884.1 - 0.095 11.8 0.0 0.14 11.3 0.0 1.2 1 0 0 1 1 1 0 Abhydrolase domain containing 18 MARVEL PF01284.23 EXF73885.1 - 6.8e-07 29.4 13.3 6.1e-06 26.3 13.3 1.9 1 1 0 1 1 1 1 Membrane-associating domain VIT1 PF01988.19 EXF73885.1 - 0.31 10.9 2.9 0.45 10.3 2.9 1.4 1 0 0 1 1 1 0 VIT family Spo7 PF03907.13 EXF73885.1 - 0.49 9.8 2.3 0.54 9.7 1.4 1.4 2 0 0 2 2 2 0 Spo7-like protein Methyltransf_3 PF01596.17 EXF73886.1 - 4.4e-22 78.3 0.0 6e-22 77.9 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.6 EXF73886.1 - 1.1e-11 45.7 0.0 1.8e-11 45.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF73886.1 - 4.8e-07 30.4 0.0 9.5e-07 29.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF73886.1 - 1.7e-06 28.5 0.0 3.3e-06 27.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF73886.1 - 1.6e-05 24.8 0.0 2.2e-05 24.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_15 PF09445.10 EXF73886.1 - 0.00065 19.3 0.0 0.00095 18.8 0.0 1.3 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Cons_hypoth95 PF03602.15 EXF73886.1 - 0.0094 15.6 0.0 0.013 15.1 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_23 PF13489.6 EXF73886.1 - 0.018 14.9 0.0 0.033 14.0 0.0 1.4 1 1 0 1 1 1 0 Methyltransferase domain adh_short_C2 PF13561.6 EXF73888.1 - 6e-42 143.8 0.2 4e-39 134.6 0.1 2.0 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF73888.1 - 1.2e-39 135.8 0.0 1.5e-39 135.5 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EXF73888.1 - 5.7e-12 45.9 0.1 8.2e-12 45.4 0.1 1.1 1 0 0 1 1 1 1 KR domain OB_aCoA_assoc PF01796.17 EXF73888.1 - 0.0051 16.8 0.1 0.014 15.4 0.1 1.7 1 0 0 1 1 1 1 DUF35 OB-fold domain, acyl-CoA-associated Fibrillarin PF01269.17 EXF73888.1 - 0.033 13.3 0.1 0.052 12.7 0.1 1.3 1 0 0 1 1 1 0 Fibrillarin Epimerase PF01370.21 EXF73888.1 - 0.051 13.0 0.1 0.13 11.7 0.1 1.8 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family PTR2 PF00854.21 EXF73889.1 - 7.9e-91 304.8 4.7 1.6e-90 303.8 4.7 1.4 1 1 0 1 1 1 1 POT family MFS_1 PF07690.16 EXF73889.1 - 6.7e-06 25.3 19.6 6.7e-06 25.3 19.6 2.5 2 1 0 2 2 2 1 Major Facilitator Superfamily Pkinase PF00069.25 EXF73890.1 - 5.7e-60 202.9 0.0 3.7e-35 121.6 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EXF73890.1 - 3.2e-32 111.8 0.0 1.8e-21 76.6 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EXF73890.1 - 4.2e-12 46.0 0.0 5.8e-07 29.1 0.0 2.3 2 0 0 2 2 2 2 Kinase-like Kdo PF06293.14 EXF73890.1 - 0.00083 18.8 0.0 0.002 17.5 0.0 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EXF73890.1 - 0.02 14.8 0.0 0.063 13.2 0.0 1.8 2 0 0 2 2 2 0 Phosphotransferase enzyme family RRN3 PF05327.11 EXF73890.1 - 1.6 7.2 7.0 1.4 7.4 0.1 2.2 2 0 0 2 2 2 0 RNA polymerase I specific transcription initiation factor RRN3 DUF2457 PF10446.9 EXF73890.1 - 8.2 5.5 12.1 18 4.3 12.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Pkinase PF00069.25 EXF73891.1 - 0.0018 17.7 0.0 0.0029 17.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF73891.1 - 0.011 15.0 0.0 0.081 12.2 0.0 2.1 1 1 0 1 1 1 0 Protein tyrosine kinase Med12 PF09497.10 EXF73892.1 - 2.3e-28 98.3 0.6 1.1e-27 96.1 0.4 2.4 2 0 0 2 2 2 1 Transcription mediator complex subunit Med12 UPF0139 PF03669.13 EXF73893.1 - 1.7e-07 31.0 0.0 2.3e-07 30.6 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0139) ATP_transf PF09830.9 EXF73894.1 - 5.4e-13 48.9 0.0 9.5e-13 48.1 0.0 1.4 1 0 0 1 1 1 1 ATP adenylyltransferase MOSC PF03473.17 EXF73895.1 - 6.7e-22 77.9 0.0 1.1e-21 77.3 0.0 1.3 1 0 0 1 1 1 1 MOSC domain MOSC_N PF03476.16 EXF73895.1 - 3.1e-12 46.4 0.0 5.7e-12 45.6 0.0 1.4 1 0 0 1 1 1 1 MOSC N-terminal beta barrel domain MFS_1 PF07690.16 EXF73896.1 - 6.7e-32 110.8 41.2 6.7e-32 110.8 41.2 1.6 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF73896.1 - 2.2e-06 26.8 32.9 1.3e-05 24.3 7.0 2.7 2 1 0 2 2 2 2 Sugar (and other) transporter Tyrosinase PF00264.20 EXF73897.1 - 1.4e-34 120.3 6.2 1.1e-33 117.4 6.2 2.0 1 1 0 1 1 1 1 Common central domain of tyrosinase DUF4148 PF13663.6 EXF73897.1 - 0.14 12.4 1.2 0.27 11.4 1.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4148) TPR_12 PF13424.6 EXF73898.1 - 8.4e-18 64.4 2.6 4.5e-05 23.6 0.4 6.1 4 1 1 6 6 6 4 Tetratricopeptide repeat TPR_10 PF13374.6 EXF73898.1 - 1.4e-14 53.4 1.4 0.0031 17.3 0.2 5.9 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.17 EXF73898.1 - 1.4e-09 37.3 7.2 1.1 9.5 0.4 5.8 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_MalT PF17874.1 EXF73898.1 - 3.7e-08 33.1 4.5 0.00021 20.8 0.6 2.6 1 1 1 2 2 2 2 MalT-like TPR region TPR_7 PF13176.6 EXF73898.1 - 1.6e-07 30.9 3.6 0.24 11.5 0.0 5.3 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 EXF73898.1 - 4.7e-06 26.4 5.7 6.4 7.3 0.0 6.7 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_19 PF14559.6 EXF73898.1 - 3.5e-05 24.2 10.6 0.26 11.8 2.4 5.4 3 2 2 5 5 5 1 Tetratricopeptide repeat TPR_1 PF00515.28 EXF73898.1 - 0.00047 19.9 4.9 8.6 6.4 0.1 5.2 6 0 0 6 6 6 1 Tetratricopeptide repeat NB-ARC PF00931.22 EXF73898.1 - 0.00057 19.1 0.0 1.3 8.2 0.0 2.5 2 0 0 2 2 2 2 NB-ARC domain TPR_17 PF13431.6 EXF73898.1 - 0.003 17.8 0.4 17 6.1 0.0 5.0 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_16 PF13432.6 EXF73898.1 - 0.019 15.6 2.1 3.4 8.4 0.0 4.4 5 0 0 5 5 4 0 Tetratricopeptide repeat L27 PF02828.16 EXF73898.1 - 0.03 14.1 1.0 0.22 11.3 0.1 2.7 2 0 0 2 2 2 0 L27 domain AAA_22 PF13401.6 EXF73898.1 - 0.039 14.2 0.0 0.18 12.1 0.0 2.2 1 0 0 1 1 1 0 AAA domain TPR_4 PF07721.14 EXF73898.1 - 0.058 14.0 0.4 45 5.1 0.0 4.8 5 0 0 5 5 5 0 Tetratricopeptide repeat AAA_16 PF13191.6 EXF73898.1 - 0.2 12.0 3.0 1.2 9.5 0.1 3.4 3 1 0 3 3 3 0 AAA ATPase domain TPR_14 PF13428.6 EXF73898.1 - 1.5 9.8 6.9 25 6.0 0.1 5.3 6 0 0 6 6 4 0 Tetratricopeptide repeat HEAT PF02985.22 EXF73900.1 - 4e-14 51.5 14.4 0.0034 17.5 0.0 9.8 11 0 0 11 11 9 2 HEAT repeat HEAT_EZ PF13513.6 EXF73900.1 - 4.5e-11 43.0 9.0 1.6e-07 31.7 0.0 7.0 9 0 0 9 9 7 1 HEAT-like repeat IBN_N PF03810.19 EXF73900.1 - 1.3e-10 41.0 3.5 1.3e-08 34.7 0.8 4.1 3 0 0 3 3 3 1 Importin-beta N-terminal domain HEAT_2 PF13646.6 EXF73900.1 - 1.3e-07 31.9 11.8 0.0051 17.2 0.2 6.6 4 2 3 7 7 7 3 HEAT repeats MMS19_C PF12460.8 EXF73900.1 - 1.4e-06 27.7 3.3 2.7e-06 26.8 0.4 2.5 2 1 0 2 2 2 1 RNAPII transcription regulator C-terminal CLASP_N PF12348.8 EXF73900.1 - 1.5e-05 24.7 0.6 1.1 8.7 0.1 4.7 2 2 2 4 4 4 2 CLASP N terminal DRIM PF07539.12 EXF73900.1 - 0.0013 17.1 2.3 2.8 6.1 0.4 4.3 2 1 0 3 3 3 1 Down-regulated in metastasis DUF3385 PF11865.8 EXF73900.1 - 0.0022 17.9 1.8 6.6 6.6 0.4 4.7 4 2 1 5 5 5 1 Domain of unknown function (DUF3385) Arm PF00514.23 EXF73900.1 - 0.0025 17.8 0.4 38 4.5 0.0 5.7 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat DUF3347 PF11827.8 EXF73900.1 - 0.056 13.6 1.3 0.11 12.7 1.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3347) HEAT_PBS PF03130.16 EXF73900.1 - 0.076 13.7 0.0 53 4.9 0.0 4.9 3 0 0 3 3 3 0 PBS lyase HEAT-like repeat Cse1 PF08506.10 EXF73900.1 - 0.16 10.8 0.1 2.4 6.9 0.0 2.9 2 1 1 3 3 3 0 Cse1 HMGL-like PF00682.19 EXF73901.1 - 1e-79 267.9 0.0 1.5e-79 267.3 0.0 1.2 1 0 0 1 1 1 1 HMGL-like LeuA_dimer PF08502.10 EXF73901.1 - 1.7e-23 83.0 0.0 3.4e-23 82.0 0.0 1.6 1 0 0 1 1 1 1 LeuA allosteric (dimerisation) domain Ferric_reduct PF01794.19 EXF73902.1 - 5e-23 81.6 11.2 5e-23 81.6 11.2 2.2 2 0 0 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 EXF73902.1 - 2.9e-17 63.2 0.0 3.8e-15 56.3 0.0 2.4 1 1 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EXF73902.1 - 1.7e-09 37.7 0.0 4.6e-07 29.9 0.0 2.5 1 1 0 1 1 1 1 FAD-binding domain DUF1690 PF07956.11 EXF73903.1 - 1.4e-42 145.5 4.6 1.6e-42 145.2 4.6 1.0 1 0 0 1 1 1 1 Protein of Unknown function (DUF1690) Lebercilin PF15619.6 EXF73903.1 - 0.0031 17.2 8.7 0.0038 16.9 8.7 1.1 1 0 0 1 1 1 1 Ciliary protein causing Leber congenital amaurosis disease cwf21 PF08312.12 EXF73903.1 - 0.021 15.0 2.2 0.057 13.6 1.2 2.1 1 1 1 2 2 2 0 cwf21 domain ALMT PF11744.8 EXF73903.1 - 0.2 10.5 0.7 0.24 10.2 0.7 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter FUSC PF04632.12 EXF73903.1 - 1.1 7.7 3.5 1.3 7.5 3.5 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family L27 PF02828.16 EXF73903.1 - 1.3 8.9 4.1 1.3 8.9 1.3 2.4 2 1 0 2 2 2 0 L27 domain TYW3 PF02676.14 EXF73904.1 - 1.7e-74 249.8 0.0 2.3e-74 249.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase TYW3 PAPS_reduct PF01507.19 EXF73905.1 - 8e-44 149.7 0.2 2.3e-43 148.3 0.0 1.8 2 0 0 2 2 2 1 Phosphoadenosine phosphosulfate reductase family Ribosomal_60s PF00428.19 EXF73905.1 - 5.6 7.6 11.8 79 3.9 11.1 2.5 2 0 0 2 2 2 0 60s Acidic ribosomal protein HAD PF12710.7 EXF73906.1 - 1.4e-20 74.5 0.1 1.9e-20 74.0 0.1 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EXF73906.1 - 1.7e-14 54.6 1.3 3.8e-14 53.5 1.3 1.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EXF73906.1 - 6.5e-09 35.9 0.5 4.7e-08 33.1 0.1 2.1 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EXF73906.1 - 0.00074 19.6 0.4 0.18 11.9 0.0 2.7 2 1 0 2 2 2 2 Haloacid dehalogenase-like hydrolase DUF705 PF05152.12 EXF73906.1 - 0.018 14.5 0.0 0.027 13.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF705) Put_Phosphatase PF06888.12 EXF73906.1 - 0.045 13.1 0.0 2.7 7.3 0.0 2.2 2 0 0 2 2 2 0 Putative Phosphatase DHHC PF01529.20 EXF73908.1 - 4.4e-36 123.9 6.1 4.4e-36 123.9 6.1 1.9 2 0 0 2 2 2 1 DHHC palmitoyltransferase Yip1 PF04893.17 EXF73908.1 - 0.0016 18.2 4.1 0.015 15.0 0.2 2.2 2 0 0 2 2 2 2 Yip1 domain Clr5 PF14420.6 EXF73909.1 - 1.1e-17 63.9 3.8 3.1e-17 62.5 3.8 1.8 1 0 0 1 1 1 1 Clr5 domain DUF2538 PF10804.8 EXF73909.1 - 0.023 14.5 0.0 0.039 13.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2538) Fungal_trans PF04082.18 EXF73910.1 - 7e-12 44.9 0.0 4.4e-09 35.7 0.0 2.2 1 1 1 2 2 2 2 Fungal specific transcription factor domain PhyH PF05721.13 EXF73911.1 - 4.3e-19 69.6 0.0 6.1e-19 69.1 0.0 1.2 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) Glyco_hydro_28 PF00295.17 EXF73913.1 - 9.9e-49 166.1 6.0 1.4e-48 165.7 6.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 CBM60 PF16841.5 EXF73913.1 - 0.21 12.0 0.7 1.1 9.7 0.2 2.4 2 1 0 2 2 2 0 Ca-dependent carbohydrate-binding module xylan-binding FAD_binding_4 PF01565.23 EXF73914.1 - 1.3e-18 67.1 2.6 2.4e-18 66.2 2.6 1.5 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EXF73914.1 - 0.0098 16.0 0.2 0.02 15.0 0.2 1.5 1 0 0 1 1 1 1 Berberine and berberine like ORF_12_N PF18042.1 EXF73914.1 - 0.13 12.7 0.1 0.36 11.3 0.1 1.7 1 0 0 1 1 1 0 ORF 12 gene product N-terminal FMN_bind_2 PF04299.12 EXF73915.1 - 9.2e-57 191.4 0.0 1.1e-56 191.2 0.0 1.1 1 0 0 1 1 1 1 Putative FMN-binding domain EthD PF07110.11 EXF73916.1 - 3.3e-19 69.8 0.2 5.4e-19 69.1 0.2 1.3 1 0 0 1 1 1 1 EthD domain MmlI PF09448.10 EXF73916.1 - 5.2e-06 26.9 0.0 7.6e-06 26.4 0.0 1.2 1 0 0 1 1 1 1 Methylmuconolactone methyl-isomerase MFS_1 PF07690.16 EXF73917.1 - 1.1e-32 113.3 34.3 1.1e-32 113.3 34.3 1.6 1 1 1 2 2 2 1 Major Facilitator Superfamily Ferric_reduct PF01794.19 EXF73918.1 - 1.1e-18 67.5 4.7 1.1e-18 67.5 4.7 2.3 3 0 0 3 3 3 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 EXF73918.1 - 7e-14 52.2 0.0 1.6e-12 47.8 0.0 2.4 2 1 0 2 2 2 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EXF73918.1 - 1e-12 48.1 0.1 9.1e-12 45.0 0.0 2.3 2 0 0 2 2 2 1 FAD-binding domain NAD_binding_1 PF00175.21 EXF73918.1 - 0.0003 21.4 0.0 0.16 12.6 0.0 2.6 2 0 0 2 2 2 2 Oxidoreductase NAD-binding domain Chromo PF00385.24 EXF73921.1 - 0.0011 18.8 0.1 0.0046 16.8 0.1 1.9 1 1 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Glyco_hydro_61 PF03443.14 EXF73922.1 - 3.6e-53 180.6 0.0 7.1e-53 179.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 SDH_C PF18317.1 EXF73923.1 - 0.28 11.0 1.1 0.4 10.5 1.1 1.2 1 0 0 1 1 1 0 Shikimate 5'-dehydrogenase C-terminal domain SNF2_N PF00176.23 EXF73925.1 - 2.6e-70 236.9 0.1 3.6e-70 236.4 0.1 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain CDO_I PF05995.12 EXF73925.1 - 7.6e-42 142.5 0.0 1.5e-41 141.5 0.0 1.5 1 0 0 1 1 1 1 Cysteine dioxygenase type I Helicase_C PF00271.31 EXF73925.1 - 1e-14 54.8 0.0 5.8e-14 52.4 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain zf-C3HC4_2 PF13923.6 EXF73925.1 - 1.4e-10 40.9 9.8 3.3e-10 39.6 9.8 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) HIRAN PF08797.11 EXF73925.1 - 1e-09 38.2 0.0 4.9e-09 36.0 0.0 2.0 1 1 0 1 1 1 1 HIRAN domain zf-C3HC4_3 PF13920.6 EXF73925.1 - 3.3e-09 36.5 7.9 3.3e-09 36.5 7.9 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EXF73925.1 - 1.5e-08 34.4 9.4 1.5e-08 34.4 9.4 1.9 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EXF73925.1 - 2.5e-08 34.1 8.7 2.5e-08 34.1 8.7 2.3 2 0 0 2 2 2 1 Ring finger domain zf-RING_UBOX PF13445.6 EXF73925.1 - 4.4e-07 29.8 7.7 1.3e-06 28.3 7.7 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 EXF73925.1 - 1.3e-06 28.3 9.0 2.8e-06 27.2 9.0 1.6 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EXF73925.1 - 2.9e-06 27.0 7.4 2.9e-06 27.0 7.4 1.7 2 0 0 2 2 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 EXF73925.1 - 5.7e-06 26.4 8.6 1.3e-05 25.2 8.6 1.7 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.7 EXF73925.1 - 1.7e-05 25.0 5.1 4.4e-05 23.7 5.1 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 EXF73925.1 - 0.0011 18.9 2.7 0.0037 17.3 2.7 1.8 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_6 PF14835.6 EXF73925.1 - 0.002 18.0 4.6 0.005 16.7 4.6 1.6 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_10 PF16685.5 EXF73925.1 - 0.0023 18.0 6.7 0.0067 16.5 6.7 1.7 1 0 0 1 1 1 1 zinc RING finger of MSL2 zf-RING_4 PF14570.6 EXF73925.1 - 0.0081 15.9 5.5 0.018 14.8 5.5 1.7 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-Nse PF11789.8 EXF73925.1 - 0.14 12.0 6.5 0.31 10.9 5.5 2.0 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit TBCC PF07986.12 EXF73925.1 - 0.34 10.6 3.3 3 7.6 1.9 2.3 2 0 0 2 2 2 0 Tubulin binding cofactor C zf-RING_11 PF17123.5 EXF73925.1 - 0.87 9.4 5.5 2.5 7.9 5.5 1.9 1 0 0 1 1 1 0 RING-like zinc finger SLAC1 PF03595.17 EXF73926.1 - 3.4e-88 296.0 51.6 3.9e-88 295.8 51.6 1.0 1 0 0 1 1 1 1 Voltage-dependent anion channel SRTM1 PF15872.5 EXF73926.1 - 0.13 12.4 1.8 1.2 9.4 0.2 2.5 2 0 0 2 2 2 0 Serine-rich and transmembrane domain-containing protein 1 DUF5056 PF16479.5 EXF73926.1 - 2.7 8.3 5.7 0.53 10.5 0.4 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF5056) Wyosine_form PF08608.12 EXF73927.1 - 1.1e-24 86.6 0.0 2.6e-24 85.4 0.0 1.7 1 0 0 1 1 1 1 Wyosine base formation Radical_SAM PF04055.21 EXF73927.1 - 3.1e-22 79.7 0.0 1.1e-21 77.9 0.0 2.0 2 1 0 2 2 2 1 Radical SAM superfamily Flavodoxin_1 PF00258.25 EXF73927.1 - 2.6e-12 47.2 0.2 2.3e-11 44.1 0.1 2.6 2 1 0 2 2 2 1 Flavodoxin MAS20 PF02064.15 EXF73928.1 - 7.9e-42 142.4 1.8 9.6e-42 142.1 1.8 1.0 1 0 0 1 1 1 1 MAS20 protein import receptor CSRNP_N PF16019.5 EXF73928.1 - 0.004 17.1 1.5 0.0051 16.7 1.5 1.1 1 0 0 1 1 1 1 Cysteine/serine-rich nuclear protein N-terminus AP-5_subunit_s1 PF15001.6 EXF73928.1 - 0.0067 16.4 2.7 0.0082 16.2 2.7 1.1 1 0 0 1 1 1 1 AP-5 complex subunit sigma-1 Rhabdo_ncap PF00945.18 EXF73928.1 - 0.11 11.4 0.7 0.13 11.1 0.7 1.1 1 0 0 1 1 1 0 Rhabdovirus nucleocapsid protein Ctr PF04145.15 EXF73928.1 - 0.16 12.6 0.0 0.17 12.5 0.0 1.1 1 0 0 1 1 1 0 Ctr copper transporter family Exo84_C PF16528.5 EXF73929.1 - 6.7e-75 251.4 0.0 6.7e-75 251.4 0.0 2.5 3 1 1 4 4 4 1 Exocyst component 84 C-terminal Vps51 PF08700.11 EXF73929.1 - 1.7e-14 53.7 1.0 1.7e-14 53.7 1.0 2.1 3 0 0 3 3 3 1 Vps51/Vps67 COG2 PF06148.11 EXF73929.1 - 0.33 11.1 6.2 0.059 13.4 0.7 2.3 2 1 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF615 PF04751.14 EXF73929.1 - 2.5 8.1 8.7 0.17 11.8 1.1 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF615) DUF4407 PF14362.6 EXF73929.1 - 6.6 6.0 10.2 1e+02 2.1 10.2 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) APG6_N PF17675.1 EXF73929.1 - 9.7 6.7 13.4 6.2 7.4 2.3 2.5 2 0 0 2 2 2 0 Apg6 coiled-coil region Metallophos PF00149.28 EXF73930.1 - 3.6e-38 132.1 0.5 5.8e-38 131.4 0.5 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EXF73930.1 - 0.048 14.1 0.1 0.099 13.1 0.1 1.5 1 0 0 1 1 1 0 Serine-threonine protein phosphatase N-terminal domain DUF3112 PF11309.8 EXF73931.1 - 2.6e-15 56.5 7.3 7.4e-10 38.6 1.2 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF3112) DUF2521 PF10730.9 EXF73931.1 - 0.053 13.5 0.1 0.091 12.8 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2521) SH3_1 PF00018.28 EXF73932.1 - 5.5e-05 22.7 0.1 0.00012 21.6 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EXF73932.1 - 0.00012 21.9 0.1 0.00023 21.0 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain Gly-zipper_Omp PF13488.6 EXF73932.1 - 0.024 14.6 11.5 0.087 12.8 0.1 2.4 2 0 0 2 2 2 0 Glycine zipper DAP10 PF07213.11 EXF73932.1 - 0.037 14.0 0.3 0.13 12.2 0.3 1.9 1 0 0 1 1 1 0 DAP10 membrane protein Insulin_TMD PF17870.1 EXF73932.1 - 0.23 11.6 0.1 0.46 10.6 0.1 1.5 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment CYYR1 PF10873.8 EXF73932.1 - 3.1 8.2 10.0 0.049 14.1 1.3 2.4 1 1 0 2 2 2 0 Cysteine and tyrosine-rich protein 1 Gly-zipper_YMGG PF13441.6 EXF73932.1 - 9.5 6.0 16.2 0.97 9.2 0.7 2.3 2 0 0 2 2 2 0 YMGG-like Gly-zipper Pkinase PF00069.25 EXF73933.1 - 1.1e-19 70.9 0.0 1.9e-19 70.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain HEAT PF02985.22 EXF73933.1 - 2.5e-11 42.8 7.6 0.047 14.0 0.1 6.8 6 0 0 6 6 6 3 HEAT repeat WD40 PF00400.32 EXF73933.1 - 1.1e-09 38.7 18.6 1.6e-06 28.7 0.2 6.2 6 0 0 6 6 6 2 WD domain, G-beta repeat HEAT_2 PF13646.6 EXF73933.1 - 1.4e-05 25.4 4.1 0.49 10.8 0.1 4.7 3 2 3 6 6 6 4 HEAT repeats Pkinase_Tyr PF07714.17 EXF73933.1 - 0.00024 20.5 0.0 0.00039 19.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase ANAPC4_WD40 PF12894.7 EXF73933.1 - 0.016 15.5 0.0 2.9 8.3 0.0 3.1 1 1 2 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain HEAT_EZ PF13513.6 EXF73933.1 - 0.025 15.1 3.7 0.14 12.7 0.2 3.5 4 0 0 4 4 4 0 HEAT-like repeat Kinase-like PF14531.6 EXF73933.1 - 0.032 13.5 0.0 0.061 12.6 0.0 1.4 1 1 0 1 1 1 0 Kinase-like LRR_9 PF14580.6 EXF73934.1 - 1.2e-55 187.7 0.4 1.7e-55 187.2 0.0 1.4 2 0 0 2 2 2 1 Leucine-rich repeat LRR_4 PF12799.7 EXF73934.1 - 8.4e-09 35.6 5.1 2.9e-05 24.3 0.9 3.1 3 1 1 4 4 4 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EXF73934.1 - 6.4e-08 32.3 1.1 1.8e-07 30.8 1.1 1.8 1 0 0 1 1 1 1 Leucine rich repeat DUF4349 PF14257.6 EXF73934.1 - 0.0093 15.4 1.6 0.0093 15.4 1.6 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4349) T4_Gp59_C PF08994.10 EXF73934.1 - 0.13 12.8 0.1 0.3 11.7 0.0 1.6 2 0 0 2 2 2 0 T4 gene Gp59 loader of gp41 DNA helicase C-term PspB PF06667.12 EXF73934.1 - 0.17 11.9 1.4 0.52 10.4 1.4 1.8 1 0 0 1 1 1 0 Phage shock protein B CBFD_NFYB_HMF PF00808.23 EXF73935.1 - 7.3e-12 45.4 0.1 2.1e-11 43.9 0.0 1.8 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Pol_alpha_B_N PF08418.10 EXF73935.1 - 0.046 13.7 0.6 0.056 13.4 0.6 1.1 1 0 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal Voltage_CLC PF00654.20 EXF73936.1 - 4.4e-88 295.9 26.9 4.4e-88 295.9 26.9 1.8 2 0 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.28 EXF73936.1 - 7e-11 42.4 0.1 3.8e-05 24.1 0.0 2.7 2 0 0 2 2 2 2 CBS domain EamA PF00892.20 EXF73937.1 - 0.0001 22.5 13.8 0.00088 19.4 13.8 2.0 1 1 0 1 1 1 1 EamA-like transporter family Trp_oprn_chp PF09534.10 EXF73937.1 - 0.0013 18.5 0.2 0.15 11.8 0.0 2.2 2 0 0 2 2 2 2 Tryptophan-associated transmembrane protein (Trp_oprn_chp) TMEM234 PF10639.9 EXF73937.1 - 0.072 13.1 3.5 0.11 12.5 3.4 1.4 1 1 0 1 1 1 0 Putative transmembrane family 234 TFIIA_gamma_C PF02751.14 EXF73938.1 - 4.4e-24 84.3 0.9 7.2e-24 83.7 0.9 1.3 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit TFIIA_gamma_N PF02268.16 EXF73938.1 - 2.5e-23 81.8 0.3 3.4e-23 81.4 0.3 1.2 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit, helical domain NOA36 PF06524.12 EXF73938.1 - 0.16 11.3 0.0 0.18 11.1 0.0 1.1 1 0 0 1 1 1 0 NOA36 protein ATP-synt_C PF00137.21 EXF73939.1 - 9.9e-25 86.7 34.6 4.9e-15 55.6 10.7 2.9 3 0 0 3 3 3 2 ATP synthase subunit C SLATT_5 PF18160.1 EXF73939.1 - 0.37 10.1 0.9 0.76 9.1 0.0 1.8 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain family 5 Oxidored_q2 PF00420.24 EXF73939.1 - 6.4 6.5 8.9 3.4 7.3 4.8 2.7 1 1 2 3 3 3 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L MoCF_biosynth PF00994.24 EXF73940.1 - 6.9e-53 178.2 0.8 1.2e-28 99.5 0.0 2.4 2 0 0 2 2 2 2 Probable molybdopterin binding domain MoeA_N PF03453.17 EXF73940.1 - 5e-40 136.8 2.4 8.4e-40 136.1 2.4 1.4 1 0 0 1 1 1 1 MoeA N-terminal region (domain I and II) MoeA_C PF03454.15 EXF73940.1 - 3.6e-16 59.1 0.1 1.1e-15 57.6 0.1 1.9 1 0 0 1 1 1 1 MoeA C-terminal region (domain IV) SelP_N PF04592.14 EXF73940.1 - 0.37 10.1 14.0 0.6 9.5 14.0 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region RNase_P_Rpp14 PF01900.19 EXF73941.1 - 3.5e-39 133.2 0.0 4.4e-39 132.9 0.0 1.1 1 0 0 1 1 1 1 Rpp14/Pop5 family ATP_bind_1 PF03029.17 EXF73942.1 - 2.7e-79 266.4 0.0 3.7e-79 265.9 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein MeaB PF03308.16 EXF73942.1 - 0.0086 15.1 0.0 0.015 14.3 0.0 1.3 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_31 PF13614.6 EXF73942.1 - 0.0092 15.9 0.0 0.77 9.6 0.0 2.4 1 1 0 2 2 2 1 AAA domain AAA_29 PF13555.6 EXF73942.1 - 0.012 15.3 0.0 0.025 14.3 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 EXF73942.1 - 0.052 13.6 0.0 0.48 10.5 0.0 2.3 1 1 0 1 1 1 0 50S ribosome-binding GTPase Zeta_toxin PF06414.12 EXF73942.1 - 0.077 12.3 0.0 0.22 10.8 0.0 1.8 1 0 0 1 1 1 0 Zeta toxin AAA_17 PF13207.6 EXF73942.1 - 0.079 13.4 0.1 0.19 12.2 0.1 1.6 1 0 0 1 1 1 0 AAA domain GTP_EFTU PF00009.27 EXF73942.1 - 0.085 12.4 0.0 0.84 9.1 0.0 2.4 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain KTI12 PF08433.10 EXF73942.1 - 0.085 12.3 0.0 0.15 11.5 0.0 1.4 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_18 PF13238.6 EXF73942.1 - 0.12 13.0 0.1 0.31 11.6 0.1 1.9 1 1 0 1 1 1 0 AAA domain cNMP_binding PF00027.29 EXF73943.1 - 2.7e-28 97.9 0.8 1.4e-15 57.1 0.1 5.6 6 0 0 6 6 6 4 Cyclic nucleotide-binding domain Patatin PF01734.22 EXF73943.1 - 8.8e-15 55.4 4.6 2.3e-13 50.8 4.6 2.7 1 1 0 1 1 1 1 Patatin-like phospholipase NPR3 PF03666.13 EXF73944.1 - 5.6 5.7 5.6 7.2 5.3 5.6 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Pyridoxal_deC PF00282.19 EXF73945.1 - 1.8e-108 362.6 0.0 2.1e-108 362.4 0.0 1.0 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Mur_ligase PF01225.25 EXF73946.1 - 0.12 12.8 0.0 0.35 11.2 0.0 1.8 1 0 0 1 1 1 0 Mur ligase family, catalytic domain CP2 PF04516.15 EXF73947.1 - 6.1e-86 287.4 0.0 8.7e-86 286.9 0.0 1.2 1 0 0 1 1 1 1 CP2 transcription factor Tektin PF03148.14 EXF73947.1 - 0.092 11.5 0.0 0.15 10.8 0.0 1.2 1 0 0 1 1 1 0 Tektin family AKNA PF12443.8 EXF73947.1 - 0.12 13.1 0.4 0.32 11.7 0.4 1.8 1 0 0 1 1 1 0 AT-hook-containing transcription factor TMF_DNA_bd PF12329.8 EXF73947.1 - 0.18 11.8 0.5 0.39 10.7 0.5 1.5 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding FAD_binding_4 PF01565.23 EXF73953.1 - 7.4e-09 35.5 0.0 9e-08 31.9 0.0 2.3 1 1 0 1 1 1 1 FAD binding domain ALO PF04030.14 EXF73953.1 - 1.2e-06 28.6 1.3 0.0057 16.5 0.1 2.2 2 0 0 2 2 2 2 D-arabinono-1,4-lactone oxidase Chol_subst-bind PF09129.11 EXF73953.1 - 3.1 6.7 6.8 26 3.6 6.8 2.4 1 1 0 1 1 1 0 Cholesterol oxidase, substrate-binding HET PF06985.11 EXF73954.1 - 0.02 15.3 0.2 0.053 13.9 0.2 1.7 1 0 0 1 1 1 0 Heterokaryon incompatibility protein (HET) MFS_1 PF07690.16 EXF73955.1 - 4.5e-36 124.5 35.4 2.5e-35 122.1 34.3 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF73955.1 - 3.2e-11 42.7 7.5 3.2e-11 42.7 7.5 2.1 2 1 0 2 2 2 1 Sugar (and other) transporter Sm_multidrug_ex PF06695.11 EXF73955.1 - 0.001 19.7 3.3 1.4 9.6 3.1 2.9 2 0 0 2 2 2 2 Putative small multi-drug export protein EB PF01683.18 EXF73956.1 - 0.0062 16.8 2.7 0.016 15.5 2.7 1.6 1 0 0 1 1 1 1 EB module Ank_3 PF13606.6 EXF73957.1 - 1.5e-07 31.1 0.0 0.0028 18.0 0.0 3.9 4 0 0 4 4 4 2 Ankyrin repeat Ank_2 PF12796.7 EXF73957.1 - 1.6e-06 28.6 0.0 0.021 15.4 0.0 3.2 3 0 0 3 3 3 2 Ankyrin repeats (3 copies) Ank PF00023.30 EXF73957.1 - 4e-06 27.0 0.1 0.038 14.4 0.0 3.8 3 1 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 EXF73957.1 - 0.0054 17.0 0.0 0.039 14.3 0.0 2.4 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 EXF73957.1 - 0.0077 16.8 0.0 1 10.0 0.0 3.7 4 0 0 4 4 4 1 Ankyrin repeats (many copies) Glyco_hydro_18 PF00704.28 EXF73960.1 - 3.8e-73 246.9 0.2 4.6e-73 246.7 0.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Chitin_bind_1 PF00187.19 EXF73960.1 - 1.7e-08 34.8 21.1 1.7e-08 34.8 21.1 2.3 2 0 0 2 2 2 1 Chitin recognition protein DUF4015 PF13200.6 EXF73960.1 - 0.0023 17.1 0.0 0.0032 16.6 0.0 1.1 1 0 0 1 1 1 1 Putative glycosyl hydrolase domain RST PF12174.8 EXF73960.1 - 0.11 12.5 0.2 0.25 11.3 0.1 1.6 2 0 0 2 2 2 0 RCD1-SRO-TAF4 (RST) plant domain 2OG-FeII_Oxy PF03171.20 EXF73961.1 - 1.4e-19 70.4 0.0 3e-19 69.4 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 EXF73961.1 - 2.7e-16 60.4 0.0 4.9e-16 59.5 0.0 1.4 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal DUF167 PF02594.16 EXF73962.1 - 1.2e-22 79.8 0.7 1.9e-22 79.2 0.2 1.6 2 0 0 2 2 2 1 Uncharacterised ACR, YggU family COG1872 p450 PF00067.22 EXF73964.1 - 6e-60 203.3 0.0 8.5e-60 202.8 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 Glyco_hydro_28 PF00295.17 EXF73965.1 - 6.4e-46 156.9 10.3 2.7e-44 151.6 6.6 2.1 2 0 0 2 2 2 2 Glycosyl hydrolases family 28 PUF PF00806.19 EXF73966.1 - 4.6e-12 44.9 0.0 0.14 11.9 0.0 6.2 6 0 0 6 6 6 4 Pumilio-family RNA binding repeat Troponin-I_N PF11636.8 EXF73966.1 - 0.068 13.1 0.3 0.2 11.6 0.3 1.8 1 0 0 1 1 1 0 Troponin I residues 1-32 Pyridoxal_deC PF00282.19 EXF73967.1 - 5.8e-76 255.6 0.0 7.4e-76 255.3 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Beta_elim_lyase PF01212.21 EXF73967.1 - 5.7e-06 25.8 0.0 1.1e-05 24.9 0.0 1.5 2 0 0 2 2 2 1 Beta-eliminating lyase Aminotran_5 PF00266.19 EXF73967.1 - 0.00032 19.8 0.0 0.00052 19.1 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Neuralized PF07177.12 EXF73967.1 - 0.17 11.9 0.0 1 9.4 0.0 2.2 3 0 0 3 3 3 0 Neuralized T3SSipB PF16535.5 EXF73968.1 - 0.0017 18.8 2.0 0.0017 18.8 2.0 4.7 4 1 0 4 4 4 1 Type III cell invasion protein SipB DUF2441 PF10386.9 EXF73968.1 - 0.054 13.5 1.3 0.1 12.6 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2441) YfcL PF08891.11 EXF73968.1 - 0.37 11.1 4.0 0.35 11.2 1.5 2.3 2 0 0 2 2 2 0 YfcL protein RloB PF13707.6 EXF73968.1 - 0.64 10.2 5.5 0.16 12.2 0.2 2.5 2 1 0 2 2 2 0 RloB-like protein TPR_MLP1_2 PF07926.12 EXF73968.1 - 1.4 9.0 30.9 0.07 13.2 1.4 4.1 4 0 0 4 4 4 0 TPR/MLP1/MLP2-like protein Exonuc_VII_S PF02609.16 EXF73968.1 - 5.2 7.2 6.8 0.64 10.1 0.2 2.9 3 0 0 3 3 3 0 Exonuclease VII small subunit Laminin_I PF06008.14 EXF73969.1 - 0.034 13.9 2.1 0.13 12.0 0.0 2.5 3 0 0 3 3 3 0 Laminin Domain I DUF745 PF05335.13 EXF73969.1 - 0.037 13.8 0.7 4.8 6.9 0.1 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF745) SH3BP5 PF05276.14 EXF73969.1 - 0.037 13.8 0.0 0.12 12.1 0.0 1.8 2 0 0 2 2 2 0 SH3 domain-binding protein 5 (SH3BP5) POTRA_TamA_1 PF17243.2 EXF73969.1 - 2.1 8.5 4.3 28 4.9 0.1 3.3 3 0 0 3 3 3 0 POTRA domain TamA domain 1 Peptidase_C58 PF03543.14 EXF73970.1 - 5.5e-05 23.0 0.0 0.04 13.6 0.0 2.2 2 0 0 2 2 2 2 Yersinia/Haemophilus virulence surface antigen Ras PF00071.22 EXF73971.1 - 4e-39 133.8 0.0 2.2e-25 89.1 0.0 2.1 2 0 0 2 2 2 2 Ras family Roc PF08477.13 EXF73971.1 - 3e-12 46.8 0.2 1.1e-11 45.0 0.0 2.0 3 0 0 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EXF73971.1 - 0.00029 20.4 0.0 0.001 18.5 0.0 1.8 2 0 0 2 2 2 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EXF73971.1 - 0.0013 18.8 0.0 0.0023 18.0 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EXF73971.1 - 0.05 13.1 0.1 0.58 9.7 0.0 2.5 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain PRK PF00485.18 EXF73971.1 - 0.1 12.3 0.0 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family XFP_N PF09364.10 EXF73972.1 - 9.7e-166 551.1 0.0 1.3e-165 550.7 0.0 1.1 1 0 0 1 1 1 1 XFP N-terminal domain XFP PF03894.15 EXF73972.1 - 2.7e-82 274.7 0.0 4.5e-82 274.0 0.0 1.3 1 0 0 1 1 1 1 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase XFP_C PF09363.10 EXF73972.1 - 1.2e-80 269.7 0.0 1.8e-80 269.2 0.0 1.2 1 0 0 1 1 1 1 XFP C-terminal domain Oxidored_FMN PF00724.20 EXF73975.1 - 3.5e-39 135.0 0.0 4.4e-39 134.7 0.0 1.1 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family DUF4817 PF16087.5 EXF73976.1 - 0.2 11.5 0.0 0.51 10.2 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain (DUF4817) DUF1100 PF06500.11 EXF73977.1 - 2.4e-07 29.9 0.0 3.5e-07 29.4 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1100) Peptidase_S15 PF02129.18 EXF73977.1 - 6e-05 22.8 0.5 0.00015 21.4 0.2 1.7 2 0 0 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) Peptidase_S9 PF00326.21 EXF73977.1 - 0.00012 21.6 0.0 0.00026 20.5 0.0 1.5 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 EXF73977.1 - 0.00035 21.3 6.8 0.00035 21.3 6.8 1.5 1 1 1 2 2 2 1 Alpha/beta hydrolase family AXE1 PF05448.12 EXF73977.1 - 0.019 13.6 0.0 0.9 8.1 0.0 2.2 1 1 0 1 1 1 0 Acetyl xylan esterase (AXE1) Abhydrolase_1 PF00561.20 EXF73977.1 - 0.026 14.2 0.1 0.071 12.7 0.1 1.7 2 0 0 2 2 2 0 alpha/beta hydrolase fold BAAT_C PF08840.11 EXF73977.1 - 0.032 14.2 0.0 0.059 13.3 0.0 1.4 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal DLH PF01738.18 EXF73977.1 - 0.064 12.8 0.0 0.72 9.4 0.0 2.4 2 1 0 2 2 2 0 Dienelactone hydrolase family Zn_clus PF00172.18 EXF73979.1 - 8.9e-05 22.5 5.1 0.00017 21.6 5.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EXF73979.1 - 0.0031 16.4 0.0 0.005 15.7 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Integrin_alpha PF00357.20 EXF73979.1 - 0.18 11.8 0.2 0.47 10.5 0.2 1.7 1 0 0 1 1 1 0 Integrin alpha cytoplasmic region DNA_pol_A_exo1 PF01612.20 EXF73980.1 - 1.7e-13 50.6 0.0 4.3e-13 49.4 0.0 1.6 1 1 0 1 1 1 1 3'-5' exonuclease MFS_1 PF07690.16 EXF73981.1 - 8.6e-13 47.9 14.2 8.6e-13 47.9 14.2 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily LapA_dom PF06305.11 EXF73981.1 - 1.7 8.5 6.4 0.48 10.3 0.1 3.1 2 1 1 3 3 3 0 Lipopolysaccharide assembly protein A domain Glyco_hydro_61 PF03443.14 EXF73982.1 - 1.8e-57 194.6 0.3 2.3e-57 194.3 0.3 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 NPCBM_assoc PF10633.9 EXF73982.1 - 0.058 13.7 0.2 0.22 11.8 0.0 2.1 2 0 0 2 2 2 0 NPCBM-associated, NEW3 domain of alpha-galactosidase Peptidase_M20 PF01546.28 EXF73983.1 - 1.5e-34 119.6 0.0 1.8e-34 119.3 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M28 PF04389.17 EXF73983.1 - 0.0017 18.1 0.0 0.0037 17.0 0.0 1.6 2 0 0 2 2 2 1 Peptidase family M28 M20_dimer PF07687.14 EXF73983.1 - 0.0033 17.3 0.0 0.011 15.7 0.0 1.8 2 1 0 2 2 2 1 Peptidase dimerisation domain Phage_G PF02306.15 EXF73983.1 - 0.092 12.5 0.0 0.23 11.2 0.0 1.6 2 0 0 2 2 2 0 Major spike protein (G protein) EHN PF06441.12 EXF73984.1 - 3.8e-37 127.0 2.2 8.3e-36 122.7 0.1 2.3 2 0 0 2 2 2 1 Epoxide hydrolase N terminus Abhydrolase_1 PF00561.20 EXF73984.1 - 3.5e-13 49.8 0.0 5.4e-13 49.2 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EXF73984.1 - 0.0021 18.7 0.6 0.0042 17.7 0.6 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family MIP PF00230.20 EXF73985.1 - 1.4e-44 152.5 14.9 1.8e-44 152.1 14.9 1.0 1 0 0 1 1 1 1 Major intrinsic protein ANAPC4_WD40 PF12894.7 EXF73986.1 - 0.00096 19.4 0.1 0.16 12.3 0.0 3.1 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 EXF73986.1 - 0.078 12.5 0.0 0.14 11.7 0.0 1.4 1 1 0 1 1 1 0 PQQ-like domain WRW PF10206.9 EXF73986.1 - 0.12 12.7 0.1 0.43 11.0 0.0 1.9 2 1 0 2 2 2 0 Mitochondrial F1F0-ATP synthase, subunit f Fungal_trans PF04082.18 EXF73987.1 - 6.5e-17 61.4 5.2 6.5e-17 61.4 5.2 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 EXF73987.1 - 0.00012 22.3 1.5 0.00012 22.3 1.5 2.7 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EXF73987.1 - 0.0012 19.5 1.1 0.0012 19.5 1.1 3.3 2 0 0 2 2 2 1 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EXF73987.1 - 0.09 13.2 8.0 0.9 10.1 4.2 2.6 2 0 0 2 2 2 0 Zinc-finger double domain zf-Di19 PF05605.12 EXF73987.1 - 0.095 13.0 1.4 0.21 11.9 1.4 1.5 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding FAD_binding_3 PF01494.19 EXF73988.1 - 1.4e-18 67.3 0.0 2.2e-18 66.6 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Lactamase_B_2 PF12706.7 EXF73988.1 - 2.5e-06 27.2 0.0 4.8e-06 26.2 0.0 1.5 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 EXF73988.1 - 3.2e-06 27.1 0.0 0.00046 20.1 0.0 2.3 2 0 0 2 2 2 2 Beta-lactamase superfamily domain Lactamase_B PF00753.27 EXF73988.1 - 3.7e-05 23.8 1.0 3.7e-05 23.8 1.0 2.4 3 0 0 3 3 3 1 Metallo-beta-lactamase superfamily FAD_binding_3 PF01494.19 EXF73989.1 - 9.5e-12 44.8 0.3 3.4e-07 29.8 0.0 3.1 3 0 0 3 3 3 3 FAD binding domain NAD_binding_8 PF13450.6 EXF73989.1 - 0.00012 22.2 0.1 0.00029 21.0 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 EXF73989.1 - 0.00016 21.7 0.0 0.00027 21.0 0.0 1.4 1 0 0 1 1 1 1 FAD-NAD(P)-binding DAO PF01266.24 EXF73989.1 - 0.0015 18.2 0.1 0.0022 17.6 0.1 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Trp_halogenase PF04820.14 EXF73989.1 - 0.04 12.8 0.0 0.31 9.8 0.0 2.0 2 0 0 2 2 2 0 Tryptophan halogenase K_oxygenase PF13434.6 EXF73989.1 - 0.044 12.9 0.0 0.065 12.4 0.0 1.2 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) GPP34 PF05719.11 EXF73989.1 - 0.081 13.0 0.0 1.5 8.8 0.0 2.6 3 1 0 3 3 3 0 Golgi phosphoprotein 3 (GPP34) Aldo_ket_red PF00248.21 EXF73990.1 - 4e-31 108.3 0.0 1.1e-30 106.9 0.0 1.6 1 1 0 1 1 1 1 Aldo/keto reductase family p450 PF00067.22 EXF73991.1 - 8.3e-58 196.2 0.0 1.2e-57 195.7 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 FAD_binding_3 PF01494.19 EXF73992.1 - 2.2e-27 96.2 0.0 3.8e-14 52.7 0.0 2.0 2 0 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 EXF73992.1 - 0.00059 20.0 0.8 0.0013 18.9 0.8 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Trp_halogenase PF04820.14 EXF73992.1 - 0.0014 17.5 0.4 0.029 13.2 0.2 2.0 2 0 0 2 2 2 1 Tryptophan halogenase FAD_binding_2 PF00890.24 EXF73992.1 - 0.011 14.8 0.3 0.047 12.8 0.5 1.8 2 0 0 2 2 2 0 FAD binding domain DAO PF01266.24 EXF73992.1 - 0.029 13.9 1.5 0.029 13.9 1.5 1.8 2 1 0 2 2 2 0 FAD dependent oxidoreductase DUF4689 PF15755.5 EXF73993.1 - 0.22 11.1 1.0 0.41 10.2 1.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4689) Abhydrolase_1 PF00561.20 EXF73994.1 - 8.1e-20 71.5 0.0 1.9e-18 67.0 0.0 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_4 PF08386.10 EXF73994.1 - 1.5e-13 50.7 0.0 3.3e-13 49.6 0.0 1.5 1 0 0 1 1 1 1 TAP-like protein Sugar_tr PF00083.24 EXF73995.1 - 1e-79 268.5 21.9 1.2e-79 268.3 21.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF73995.1 - 2.4e-13 49.8 43.0 3.3e-13 49.3 16.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Amidohydro_2 PF04909.14 EXF73996.1 - 6e-30 105.0 0.2 7.1e-30 104.8 0.2 1.1 1 0 0 1 1 1 1 Amidohydrolase UCH PF00443.29 EXF73997.1 - 1.1e-39 136.5 0.0 1.6e-39 135.9 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RPT PF13446.6 EXF73997.1 - 1e-16 60.5 3.5 1.4e-11 44.1 0.0 3.9 3 1 0 3 3 3 2 A repeated domain in UCH-protein UCH_1 PF13423.6 EXF73997.1 - 4e-06 26.6 0.8 0.019 14.6 0.2 2.4 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase Tim17 PF02466.19 EXF73998.1 - 7.8e-07 29.5 10.2 1.2e-06 28.9 8.7 1.9 1 1 1 2 2 2 1 Tim17/Tim22/Tim23/Pmp24 family ABA_WDS PF02496.16 EXF73998.1 - 1.8 9.1 5.3 4.7 7.7 0.6 2.9 3 0 0 3 3 3 0 ABA/WDS induced protein MutS_V PF00488.21 EXF73999.1 - 7.4e-84 280.5 0.1 1.5e-83 279.5 0.1 1.5 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 EXF73999.1 - 1.9e-38 132.6 0.7 7.9e-38 130.6 0.6 2.1 2 0 0 2 2 2 1 MutS domain III MutS_II PF05188.17 EXF73999.1 - 5.7e-23 81.7 2.0 6.4e-22 78.3 0.1 2.9 3 0 0 3 3 3 1 MutS domain II MutS_I PF01624.20 EXF73999.1 - 6.4e-21 74.7 0.0 3.8e-20 72.2 0.0 2.2 2 0 0 2 2 2 1 MutS domain I MutS_IV PF05190.18 EXF73999.1 - 3.5e-18 65.7 3.2 6.6e-18 64.9 1.3 2.4 2 0 0 2 2 2 1 MutS family domain IV AAA_27 PF13514.6 EXF73999.1 - 0.072 12.7 0.0 0.2 11.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain Com_YlbF PF06133.11 EXF73999.1 - 0.31 11.7 4.2 5.3 7.7 0.1 3.1 3 0 0 3 3 3 0 Control of competence regulator ComK, YlbF/YmcA tRNA_m1G_MT PF01746.21 EXF74000.1 - 2.3e-29 102.5 0.0 4.3e-21 75.5 0.0 2.2 2 0 0 2 2 2 2 tRNA (Guanine-1)-methyltransferase ANAPC16 PF17256.2 EXF74000.1 - 0.036 14.4 0.4 0.077 13.4 0.4 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex, subunit 16 DNA_primase_S PF01896.19 EXF74001.1 - 1.7e-64 217.1 0.1 2.4e-64 216.6 0.1 1.2 1 0 0 1 1 1 1 DNA primase small subunit HSF_DNA-bind PF00447.17 EXF74002.1 - 7.9e-31 106.5 2.5 1.6e-30 105.6 2.5 1.5 1 0 0 1 1 1 1 HSF-type DNA-binding Response_reg PF00072.24 EXF74002.1 - 3.2e-21 75.6 0.0 7.4e-21 74.4 0.0 1.7 1 0 0 1 1 1 1 Response regulator receiver domain YabA PF06156.13 EXF74002.1 - 0.11 13.2 5.1 0.24 12.1 5.1 1.5 1 0 0 1 1 1 0 Initiation control protein YabA DUF16 PF01519.16 EXF74002.1 - 0.14 12.7 5.5 0.27 11.7 5.5 1.4 1 0 0 1 1 1 0 Protein of unknown function DUF16 USP8_interact PF08941.10 EXF74002.1 - 0.99 9.2 4.8 1.9 8.2 4.8 1.4 1 0 0 1 1 1 0 USP8 interacting DivIC PF04977.15 EXF74002.1 - 1.1 9.1 4.2 2.1 8.2 4.2 1.5 1 0 0 1 1 1 0 Septum formation initiator SlyX PF04102.12 EXF74002.1 - 1.3 9.7 10.7 1.5 9.5 8.6 2.2 1 1 1 2 2 2 0 SlyX Fic PF02661.18 EXF74003.1 - 7.2e-17 62.1 0.0 6e-16 59.1 0.0 2.3 2 0 0 2 2 2 1 Fic/DOC family Metallophos PF00149.28 EXF74004.1 - 6e-10 40.0 0.1 9.7e-10 39.3 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EXF74004.1 - 1.5e-07 31.8 0.0 5.8e-06 26.6 0.0 2.1 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain W2 PF02020.18 EXF74005.1 - 2e-21 75.9 2.2 4.3e-21 74.8 2.2 1.6 1 0 0 1 1 1 1 eIF4-gamma/eIF5/eIF2-epsilon Hexapep PF00132.24 EXF74005.1 - 6.1e-08 32.1 7.9 4.4e-05 23.0 3.2 3.6 1 1 1 2 2 2 2 Bacterial transferase hexapeptide (six repeats) NTP_transferase PF00483.23 EXF74005.1 - 0.00055 19.6 0.0 0.00097 18.8 0.0 1.3 1 0 0 1 1 1 1 Nucleotidyl transferase DUF4954 PF16314.5 EXF74005.1 - 0.00097 17.4 0.3 0.0017 16.6 0.3 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4954) Fucokinase PF07959.12 EXF74005.1 - 0.0042 16.1 1.1 0.33 9.8 0.2 2.2 1 1 1 2 2 2 2 L-fucokinase NTP_transf_3 PF12804.7 EXF74005.1 - 0.0077 16.6 0.0 0.023 15.0 0.0 1.8 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep_2 PF14602.6 EXF74005.1 - 0.046 13.5 7.6 0.28 11.0 1.5 3.5 1 1 2 3 3 3 0 Hexapeptide repeat of succinyl-transferase HAD_SAK_1 PF10307.9 EXF74006.1 - 4.8e-80 268.2 0.0 6.6e-80 267.7 0.0 1.2 1 0 0 1 1 1 1 HAD domain family 1 in Swiss Army Knife RNA repair proteins Abhydrolase_3 PF07859.13 EXF74008.1 - 5e-45 154.0 0.0 6.5e-45 153.6 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 EXF74008.1 - 0.00012 21.2 0.4 0.00024 20.1 0.4 1.4 1 1 0 1 1 1 1 Carboxylesterase family Peptidase_S9 PF00326.21 EXF74008.1 - 0.017 14.6 0.3 0.12 11.8 0.5 2.1 3 0 0 3 3 3 0 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 EXF74008.1 - 0.052 12.8 0.2 0.19 10.9 0.2 1.8 1 1 0 1 1 1 0 Serine aminopeptidase, S33 AXE1 PF05448.12 EXF74008.1 - 0.13 10.9 0.0 0.23 10.1 0.0 1.4 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) Lipase_GDSL_2 PF13472.6 EXF74009.1 - 9.6e-13 48.9 0.2 1.3e-12 48.5 0.2 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EXF74009.1 - 3.1e-06 27.3 0.0 4.3e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase ALGX PF16822.5 EXF74009.1 - 0.021 14.5 1.0 0.084 12.5 0.6 1.9 2 0 0 2 2 2 0 SGNH hydrolase-like domain, acetyltransferase AlgX PaRep2a PF07903.11 EXF74009.1 - 0.14 12.0 0.1 0.39 10.6 0.0 1.7 2 0 0 2 2 2 0 PaRep2a protein MFS_1 PF07690.16 EXF74011.1 - 3.1e-30 105.3 63.9 8.7e-28 97.3 35.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2781 PF10914.8 EXF74011.1 - 0.37 11.2 6.9 0.22 11.9 2.8 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF2781) GTP1_OBG PF01018.22 EXF74012.1 - 0.073 12.7 0.6 2.3 7.8 0.2 2.1 2 0 0 2 2 2 0 GTP1/OBG NmrA PF05368.13 EXF74013.1 - 8.8e-37 126.9 0.0 1.3e-36 126.4 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EXF74013.1 - 3.2e-16 59.8 0.0 4e-16 59.5 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EXF74013.1 - 4e-05 23.2 0.0 5.7e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EXF74013.1 - 0.00081 18.5 0.0 0.0011 18.0 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family KR PF08659.10 EXF74013.1 - 0.0032 17.4 0.3 0.0049 16.8 0.3 1.3 1 0 0 1 1 1 1 KR domain NAD_binding_4 PF07993.12 EXF74013.1 - 0.0066 15.6 0.0 0.097 11.8 0.0 2.2 2 0 0 2 2 2 1 Male sterility protein Polysacc_synt_2 PF02719.15 EXF74013.1 - 0.036 13.2 0.0 0.054 12.6 0.0 1.4 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 EXF74013.1 - 0.09 12.2 0.0 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 EXF74015.1 - 1.9e-15 57.0 0.0 8.7e-15 54.8 0.0 2.1 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EXF74015.1 - 2.3e-12 46.5 0.0 4.7e-12 45.5 0.0 1.5 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 EXF74015.1 - 2.3e-11 44.0 0.0 3.4e-11 43.4 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 EXF74015.1 - 2.7e-10 40.2 0.0 1.5e-09 37.7 0.0 1.8 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 EXF74015.1 - 2.3e-08 33.5 0.0 7.1e-05 22.1 0.0 2.1 2 0 0 2 2 2 2 Male sterility protein NmrA PF05368.13 EXF74015.1 - 4.3e-08 33.0 0.0 6.8e-08 32.4 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family Polysacc_synt_2 PF02719.15 EXF74015.1 - 1.6e-05 24.2 0.0 2.6e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein adh_short PF00106.25 EXF74015.1 - 0.00018 21.1 0.0 0.0006 19.3 0.0 1.8 2 0 0 2 2 2 1 short chain dehydrogenase Fungal_trans PF04082.18 EXF74016.1 - 6.5e-14 51.6 0.1 1.4e-13 50.5 0.0 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain IMD PF08397.11 EXF74016.1 - 0.16 11.4 0.0 0.6 9.5 0.0 2.0 2 1 0 2 2 2 0 IRSp53/MIM homology domain DUF2397 PF09660.10 EXF74017.1 - 0.11 11.4 0.0 0.12 11.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2397) Pectate_lyase_3 PF12708.7 EXF74018.1 - 3.3e-05 23.8 0.1 0.0011 18.9 0.1 2.4 1 1 1 2 2 2 2 Pectate lyase superfamily protein Rpn3_C PF08375.11 EXF74019.1 - 5.4e-26 90.8 1.7 1.8e-25 89.1 1.7 1.9 1 0 0 1 1 1 1 Proteasome regulatory subunit C-terminal PCI PF01399.27 EXF74019.1 - 1.1e-20 74.0 0.3 4.5e-20 72.1 0.0 2.1 3 0 0 3 3 3 1 PCI domain TPR_2 PF07719.17 EXF74019.1 - 0.0076 16.3 0.1 0.025 14.7 0.1 2.0 1 0 0 1 1 1 1 Tetratricopeptide repeat TFIID_20kDa PF03847.13 EXF74020.1 - 5.6e-18 65.2 0.1 1.2e-17 64.2 0.1 1.6 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A CBFD_NFYB_HMF PF00808.23 EXF74020.1 - 0.017 15.4 1.0 0.12 12.7 0.0 2.7 3 0 0 3 3 3 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Vfa1 PF08432.10 EXF74021.1 - 4.6 7.5 20.0 0.52 10.6 7.4 2.6 3 0 0 3 3 3 0 AAA-ATPase Vps4-associated protein 1 TFIIF_alpha PF05793.12 EXF74021.1 - 9.9 4.6 40.7 1.1 7.8 30.9 2.3 2 0 0 2 2 2 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) HMG_box PF00505.19 EXF74022.1 - 1.1e-07 32.2 0.3 2.5e-07 31.0 0.3 1.7 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EXF74022.1 - 0.00011 22.8 0.2 0.00035 21.1 0.2 2.0 1 0 0 1 1 1 1 HMG-box domain Amidohydro_1 PF01979.20 EXF74023.1 - 6.3e-76 255.9 0.5 1.4e-75 254.8 0.4 1.6 2 0 0 2 2 2 1 Amidohydrolase family Urease_alpha PF00449.20 EXF74023.1 - 4.8e-55 185.1 1.7 4.8e-55 185.1 1.7 2.0 2 0 0 2 2 2 1 Urease alpha-subunit, N-terminal domain Urease_beta PF00699.20 EXF74023.1 - 4.6e-41 138.8 1.5 6.1e-41 138.4 0.1 2.0 3 0 0 3 3 3 1 Urease beta subunit Urease_gamma PF00547.18 EXF74023.1 - 7.4e-41 138.5 0.0 1.9e-40 137.2 0.0 1.7 1 0 0 1 1 1 1 Urease, gamma subunit Amidohydro_3 PF07969.11 EXF74023.1 - 2.9e-10 40.2 0.6 1.5e-06 27.9 0.0 2.3 1 1 0 2 2 2 2 Amidohydrolase family Amidohydro_2 PF04909.14 EXF74023.1 - 0.098 12.4 0.0 0.23 11.2 0.0 1.6 2 0 0 2 2 2 0 Amidohydrolase ThrE PF06738.12 EXF74024.1 - 0.037 13.4 1.4 0.056 12.8 1.4 1.2 1 0 0 1 1 1 0 Putative threonine/serine exporter Ada3 PF10198.9 EXF74025.1 - 6.9e-56 188.0 0.2 6.9e-56 188.0 0.2 3.4 3 1 0 3 3 3 1 Histone acetyltransferases subunit 3 LRIF1 PF15741.5 EXF74025.1 - 0.16 10.4 4.7 0.28 9.7 4.7 1.3 1 0 0 1 1 1 0 Ligand-dependent nuclear receptor-interacting factor 1 Ribosomal_60s PF00428.19 EXF74025.1 - 0.19 12.3 18.6 0.18 12.4 12.5 3.2 3 0 0 3 3 3 0 60s Acidic ribosomal protein DUF3419 PF11899.8 EXF74026.1 - 4e-165 549.7 0.0 5.1e-165 549.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3419) Methyltransf_23 PF13489.6 EXF74026.1 - 7.5e-14 51.9 0.0 7.1e-13 48.7 0.0 2.4 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF74026.1 - 2.7e-09 37.6 0.0 2e-06 28.4 0.0 3.8 4 0 0 4 4 4 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF74026.1 - 1.6e-08 35.2 0.0 9.8e-08 32.7 0.0 2.4 3 0 0 3 3 3 1 Methyltransferase domain Ubie_methyltran PF01209.18 EXF74026.1 - 1.1e-07 31.4 0.1 0.0003 20.2 0.0 2.7 3 0 0 3 3 3 2 ubiE/COQ5 methyltransferase family Methyltransf_11 PF08241.12 EXF74026.1 - 1.8e-07 31.7 0.0 5.1e-05 23.8 0.0 3.7 4 0 0 4 4 4 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF74026.1 - 2.1e-07 30.9 0.0 1.1e-06 28.5 0.0 2.1 2 1 0 2 2 2 1 Methyltransferase domain PCMT PF01135.19 EXF74026.1 - 9.1e-05 22.3 0.0 0.00018 21.3 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CybS PF05328.12 EXF74027.1 - 8.4e-50 167.9 0.0 1.1e-49 167.5 0.0 1.1 1 0 0 1 1 1 1 CybS, succinate dehydrogenase cytochrome B small subunit Sdh_cyt PF01127.22 EXF74027.1 - 0.021 14.9 0.4 1.2 9.2 0.0 2.2 1 1 1 2 2 2 0 Succinate dehydrogenase/Fumarate reductase transmembrane subunit tRNA-synt_1b PF00579.25 EXF74028.1 - 4.3e-77 259.3 0.0 6.4e-77 258.8 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) TyrRSs_C PF16714.5 EXF74028.1 - 4.2e-47 158.9 0.0 1.6e-46 157.0 0.0 1.9 2 0 0 2 2 2 1 Tyrosyl-tRNA synthetase C-terminal domain NPR2 PF06218.11 EXF74029.1 - 8e-122 407.2 0.0 1.2e-101 340.7 0.0 2.0 1 1 1 2 2 2 2 Nitrogen permease regulator 2 RRM_4 PF10598.9 EXF74029.1 - 0.11 12.9 0.1 27 5.2 0.0 2.6 2 0 0 2 2 2 0 RNA recognition motif of the spliceosomal PrP8 ubiquitin PF00240.23 EXF74030.1 - 4.3e-19 68.0 0.0 6.6e-19 67.4 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin family UBA PF00627.31 EXF74030.1 - 3.1e-07 30.2 2.1 6.2e-06 26.0 0.0 2.6 2 0 0 2 2 2 1 UBA/TS-N domain Rad60-SLD_2 PF13881.6 EXF74030.1 - 0.00062 19.8 0.0 0.0011 19.0 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD PF11976.8 EXF74030.1 - 0.00077 19.3 0.1 0.0012 18.6 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 EXF74030.1 - 0.018 15.6 0.0 0.033 14.7 0.0 1.3 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain HOIP-UBA PF16678.5 EXF74030.1 - 0.024 14.6 0.0 0.04 13.9 0.0 1.3 1 0 0 1 1 1 0 HOIP UBA domain pair STI1 PF17830.1 EXF74030.1 - 0.27 11.2 22.3 0.24 11.4 3.4 3.5 3 0 0 3 3 3 0 STI1 domain ADH_zinc_N PF00107.26 EXF74031.1 - 2.3e-32 111.7 1.7 3.3e-32 111.2 1.7 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EXF74031.1 - 5.6e-13 50.1 0.1 9.8e-13 49.3 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EXF74031.1 - 2.4e-06 27.4 0.0 1.1e-05 25.3 0.0 2.0 2 1 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain TrkA_N PF02254.18 EXF74031.1 - 0.014 15.6 0.1 0.027 14.7 0.1 1.4 1 0 0 1 1 1 0 TrkA-N domain AlaDh_PNT_C PF01262.21 EXF74031.1 - 0.04 13.2 5.5 0.032 13.5 3.9 1.5 1 1 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Form-deh_trans PF09163.11 EXF74031.1 - 0.26 11.1 0.1 0.26 11.1 0.1 2.8 3 1 0 3 3 3 0 Formate dehydrogenase N, transmembrane IBN_N PF03810.19 EXF74032.1 - 1.1e-14 54.1 0.3 5.3e-13 48.7 0.0 3.8 3 1 1 4 4 4 2 Importin-beta N-terminal domain Xpo1 PF08389.12 EXF74032.1 - 0.001 19.1 0.0 0.0094 16.0 0.0 2.6 2 0 0 2 2 2 1 Exportin 1-like protein UME PF08064.13 EXF74032.1 - 0.12 12.3 0.2 0.84 9.6 0.1 2.5 2 0 0 2 2 2 0 UME (NUC010) domain Fungal_trans PF04082.18 EXF74033.1 - 3.6e-09 36.0 0.1 5e-09 35.6 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF74033.1 - 5.1e-08 32.9 7.8 1.1e-07 31.9 7.8 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pex2_Pex12 PF04757.14 EXF74034.1 - 1.4e-36 126.2 1.8 2e-36 125.7 1.8 1.2 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_4 PF15227.6 EXF74034.1 - 0.00011 22.2 4.5 0.00022 21.3 4.5 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 EXF74034.1 - 0.02 14.9 2.9 0.071 13.2 2.9 1.9 1 1 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EXF74034.1 - 0.04 13.8 1.4 0.04 13.8 1.4 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EXF74034.1 - 0.064 13.1 3.4 0.16 11.9 3.4 1.7 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Pribosyltran PF00156.27 EXF74036.1 - 1.1e-14 54.2 0.0 1.8e-14 53.6 0.0 1.4 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 EXF74036.1 - 0.0017 17.9 0.0 0.0022 17.4 0.0 1.2 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Epimerase PF01370.21 EXF74037.1 - 4e-09 36.3 0.0 0.00099 18.6 0.0 2.2 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EXF74037.1 - 3.2e-08 33.7 0.1 1.1e-07 31.9 0.1 1.8 2 0 0 2 2 2 1 NAD(P)H-binding Semialdhyde_dh PF01118.24 EXF74037.1 - 0.0015 18.9 0.1 0.0033 17.8 0.1 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain NmrA PF05368.13 EXF74037.1 - 0.0044 16.6 0.0 0.0092 15.6 0.0 1.5 2 0 0 2 2 2 1 NmrA-like family NAD_binding_4 PF07993.12 EXF74037.1 - 0.18 10.9 0.0 1.4 8.0 0.0 2.1 1 1 1 2 2 2 0 Male sterility protein Raffinose_syn PF05691.12 EXF74038.1 - 5.5e-56 189.8 6.0 2.4e-50 171.2 4.3 3.1 2 1 0 2 2 2 2 Raffinose synthase or seed imbibition protein Sip1 Glyco_hydro_31 PF01055.26 EXF74038.1 - 2e-07 30.6 1.2 3.1e-07 29.9 1.2 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Peptidase_M16 PF00675.20 EXF74039.1 - 1.1e-56 190.9 0.5 2.9e-56 189.6 0.5 1.7 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 EXF74039.1 - 1.3e-37 129.6 0.0 9.1e-37 126.8 0.0 2.0 2 0 0 2 2 2 1 Peptidase M16 inactive domain Esterase PF00756.20 EXF74039.1 - 0.0041 16.8 0.0 0.0083 15.8 0.0 1.5 1 0 0 1 1 1 1 Putative esterase Histidinol_dh PF00815.20 EXF74040.1 - 8.1e-159 529.0 4.8 1.1e-158 528.6 4.8 1.2 1 0 0 1 1 1 1 Histidinol dehydrogenase PRA-CH PF01502.18 EXF74040.1 - 2.3e-24 85.0 0.0 4.6e-24 84.0 0.0 1.5 1 0 0 1 1 1 1 Phosphoribosyl-AMP cyclohydrolase PRA-PH PF01503.17 EXF74040.1 - 3.6e-13 49.8 0.9 6.4e-13 49.0 0.2 1.9 2 0 0 2 2 2 1 Phosphoribosyl-ATP pyrophosphohydrolase Phasin_2 PF09361.10 EXF74040.1 - 0.063 13.5 3.1 0.44 10.8 0.3 3.3 3 0 0 3 3 3 0 Phasin protein TFIID-31kDa PF02291.15 EXF74041.1 - 4e-42 143.1 0.0 5.4e-42 142.7 0.0 1.2 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Presenilin PF01080.17 EXF74041.1 - 0.94 8.2 4.4 1.3 7.7 4.4 1.3 1 0 0 1 1 1 0 Presenilin Macoilin PF09726.9 EXF74041.1 - 1.3 7.5 5.0 1.7 7.1 5.0 1.2 1 0 0 1 1 1 0 Macoilin family Spt20 PF12090.8 EXF74041.1 - 1.4 8.5 10.9 2.1 7.9 10.9 1.4 1 0 0 1 1 1 0 Spt20 family Pex14_N PF04695.13 EXF74041.1 - 2.5 8.7 20.6 4.3 8.0 20.6 1.4 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Ndc1_Nup PF09531.10 EXF74041.1 - 3.7 6.1 6.5 3.9 6.0 6.5 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup ORC6 PF05460.13 EXF74041.1 - 8.5 5.5 13.1 13 5.0 13.1 1.2 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) LNS2 PF08235.13 EXF74042.1 - 1.8e-92 308.9 0.0 2.4e-92 308.5 0.0 1.2 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.14 EXF74042.1 - 1.8e-42 143.4 0.0 1e-41 141.0 0.0 2.1 2 0 0 2 2 2 1 lipin, N-terminal conserved region Acid_phosphat_B PF03767.14 EXF74042.1 - 0.0042 16.7 0.3 0.18 11.3 0.0 2.7 3 0 0 3 3 3 1 HAD superfamily, subfamily IIIB (Acid phosphatase) UDPGP PF01704.18 EXF74043.1 - 4.7e-56 190.2 0.0 6.1e-56 189.8 0.0 1.1 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase NTP_transf_3 PF12804.7 EXF74043.1 - 0.017 15.5 0.0 0.055 13.8 0.0 1.8 2 0 0 2 2 2 0 MobA-like NTP transferase domain fn3 PF00041.21 EXF74044.1 - 4.7e-08 33.3 0.0 1.3e-07 31.8 0.0 1.8 1 0 0 1 1 1 1 Fibronectin type III domain Cmc1 PF08583.10 EXF74045.1 - 6.9e-17 61.2 1.6 6.9e-17 61.2 1.6 1.9 3 0 0 3 3 3 1 Cytochrome c oxidase biogenesis protein Cmc1 like DUF3128 PF11326.8 EXF74045.1 - 0.011 16.1 5.6 0.96 9.9 5.6 2.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3128) CHCH PF06747.13 EXF74045.1 - 0.015 15.4 0.1 0.17 12.1 0.1 2.2 1 1 1 2 2 2 0 CHCH domain NpwBP PF12622.7 EXF74045.1 - 0.6 10.9 0.1 0.6 10.9 0.1 1.9 2 1 0 2 2 2 0 mRNA biogenesis factor AlaDh_PNT_N PF05222.15 EXF74046.1 - 6.1e-29 101.0 0.0 1.3e-28 99.9 0.0 1.6 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, N-terminal domain AlaDh_PNT_C PF01262.21 EXF74046.1 - 7.2e-05 22.2 0.0 0.007 15.7 0.0 2.2 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain DAO PF01266.24 EXF74047.1 - 6.5e-38 131.2 0.0 7.3e-38 131.0 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EXF74047.1 - 3.7e-05 23.0 0.0 5.3e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 EXF74047.1 - 0.00013 22.1 0.1 0.00035 20.7 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EXF74047.1 - 0.00019 20.8 0.0 0.00024 20.4 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.16 EXF74047.1 - 0.00051 19.7 0.0 0.00079 19.1 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Pyr_redox PF00070.27 EXF74047.1 - 0.00078 20.0 0.0 0.0016 19.0 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase UDPG_MGDP_dh_N PF03721.14 EXF74047.1 - 0.0013 18.4 0.2 0.0021 17.7 0.2 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_binding_7 PF13241.6 EXF74047.1 - 0.0025 18.2 0.0 0.0038 17.6 0.0 1.3 1 0 0 1 1 1 1 Putative NAD(P)-binding TrkA_N PF02254.18 EXF74047.1 - 0.014 15.6 0.0 0.022 15.0 0.0 1.3 1 0 0 1 1 1 0 TrkA-N domain 3HCDH_N PF02737.18 EXF74047.1 - 0.02 14.8 0.0 0.026 14.4 0.0 1.2 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FAD_binding_3 PF01494.19 EXF74047.1 - 0.022 14.0 0.1 0.034 13.4 0.1 1.3 1 0 0 1 1 1 0 FAD binding domain HI0933_like PF03486.14 EXF74047.1 - 0.042 12.5 0.3 0.059 12.1 0.3 1.1 1 0 0 1 1 1 0 HI0933-like protein Pyr_redox_3 PF13738.6 EXF74047.1 - 0.048 12.9 0.1 0.072 12.3 0.1 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EXF74047.1 - 0.063 12.4 0.1 0.082 12.0 0.1 1.1 1 0 0 1 1 1 0 Glucose inhibited division protein A Glyco_transf_4 PF13439.6 EXF74047.1 - 0.068 13.2 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 Glycosyltransferase Family 4 AlaDh_PNT_C PF01262.21 EXF74047.1 - 0.069 12.4 0.1 0.096 12.0 0.1 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain F420_oxidored PF03807.17 EXF74047.1 - 0.12 13.0 0.0 0.22 12.1 0.0 1.4 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Prok_Ub PF14454.6 EXF74047.1 - 0.13 12.0 0.0 9.2 6.0 0.0 2.5 2 0 0 2 2 2 0 Prokaryotic Ubiquitin Lycopene_cycl PF05834.12 EXF74047.1 - 0.16 11.0 0.0 0.22 10.5 0.0 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein Thi4 PF01946.17 EXF74047.1 - 0.2 10.8 0.1 0.4 9.9 0.1 1.4 1 0 0 1 1 1 0 Thi4 family Utp11 PF03998.13 EXF74049.1 - 4.2e-65 220.1 16.4 4.8e-65 219.9 16.4 1.0 1 0 0 1 1 1 1 Utp11 protein DUF4407 PF14362.6 EXF74049.1 - 0.085 12.2 11.1 0.0091 15.4 5.8 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) SLATT_5 PF18160.1 EXF74049.1 - 0.12 11.7 0.2 0.3 10.4 0.2 1.6 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 5 DUF3246 PF11596.8 EXF74049.1 - 0.2 11.1 1.9 0.34 10.3 1.8 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3246) FlxA PF14282.6 EXF74049.1 - 0.46 10.5 5.0 0.63 10.1 2.4 2.5 3 0 0 3 3 3 0 FlxA-like protein UPF0242 PF06785.11 EXF74049.1 - 0.82 9.7 5.9 0.3 11.2 1.3 2.1 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Glyco_hydro_47 PF01532.20 EXF74050.1 - 2.4e-173 577.3 0.1 2.7e-173 577.1 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Glyco_hydro_127 PF07944.12 EXF74050.1 - 0.027 13.0 0.1 0.75 8.2 0.1 2.4 2 1 0 2 2 2 0 Beta-L-arabinofuranosidase, GH127 Maf PF02545.14 EXF74051.1 - 6.6e-51 172.5 0.0 7.9e-51 172.2 0.0 1.1 1 0 0 1 1 1 1 Maf-like protein HLH PF00010.26 EXF74052.1 - 8.7e-09 35.2 0.0 1.5e-08 34.4 0.0 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Umbravirus_LDM PF04817.12 EXF74052.1 - 0.0081 15.5 0.3 0.009 15.4 0.3 1.1 1 0 0 1 1 1 1 Umbravirus long distance movement (LDM) family tRNA-synt_2b PF00587.25 EXF74053.1 - 6.5e-36 124.0 0.0 3.2e-32 112.0 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 EXF74053.1 - 1.7e-09 37.7 0.0 9.4e-09 35.3 0.0 2.0 2 0 0 2 2 2 1 Anticodon binding domain Aldedh PF00171.22 EXF74054.1 - 5.4e-137 457.1 1.9 6.6e-137 456.8 1.9 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Zn_clus PF00172.18 EXF74056.1 - 1.8e-05 24.8 10.4 1.8e-05 24.8 10.4 1.6 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Malectin_like PF12819.7 EXF74060.1 - 0.26 10.4 0.0 0.38 9.9 0.0 1.1 1 0 0 1 1 1 0 Malectin-like domain OPA3 PF07047.12 EXF74062.1 - 2.4e-42 143.6 13.4 2.4e-42 143.6 13.4 1.9 1 1 1 2 2 2 1 Optic atrophy 3 protein (OPA3) DUF1635 PF07795.11 EXF74062.1 - 0.0033 17.3 5.4 0.0033 17.3 5.4 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF1635) Macoilin PF09726.9 EXF74062.1 - 0.0042 15.7 12.0 0.0055 15.3 12.0 1.2 1 0 0 1 1 1 1 Macoilin family SPX PF03105.19 EXF74062.1 - 0.024 14.6 17.3 0.041 13.8 17.2 1.3 1 1 0 1 1 1 0 SPX domain CAF-1_p150 PF11600.8 EXF74062.1 - 0.029 14.1 20.7 0.087 12.5 6.4 2.3 2 0 0 2 2 2 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal PAP1 PF08601.10 EXF74062.1 - 0.051 13.3 10.9 0.086 12.6 10.9 1.4 1 0 0 1 1 1 0 Transcription factor PAP1 PDE6_gamma PF04868.12 EXF74062.1 - 0.055 13.7 0.0 0.13 12.5 0.0 1.6 1 0 0 1 1 1 0 Retinal cGMP phosphodiesterase, gamma subunit Herpes_capsid PF06112.11 EXF74062.1 - 0.065 13.3 10.5 0.13 12.3 10.5 1.5 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein RAP1 PF07218.11 EXF74062.1 - 0.19 10.0 7.3 0.22 9.8 7.3 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) VSG_B PF13206.6 EXF74062.1 - 0.58 9.4 12.2 2.3 7.4 12.2 1.8 1 1 0 1 1 1 0 Trypanosomal VSG domain DUF2052 PF09747.9 EXF74062.1 - 0.59 10.2 12.2 0.076 13.1 4.2 2.1 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) APG6_N PF17675.1 EXF74062.1 - 0.97 10.0 19.5 1 9.9 7.3 2.2 2 0 0 2 2 2 0 Apg6 coiled-coil region Occludin_ELL PF07303.13 EXF74062.1 - 1.4 9.7 9.3 0.82 10.4 1.4 2.5 2 0 0 2 2 2 0 Occludin homology domain Peptidase_S64 PF08192.11 EXF74062.1 - 2 6.8 9.2 2.4 6.5 9.2 1.2 1 0 0 1 1 1 0 Peptidase family S64 Nop25 PF09805.9 EXF74062.1 - 2.1 8.8 17.9 0.59 10.6 6.2 2.2 2 0 0 2 2 2 0 Nucleolar protein 12 (25kDa) ADIP PF11559.8 EXF74062.1 - 2.2 8.3 19.8 0.29 11.2 6.4 2.2 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding GREB1 PF15782.5 EXF74062.1 - 2.6 5.0 8.4 3.4 4.6 8.4 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF1645 PF07816.11 EXF74062.1 - 3 8.4 20.3 4.1 7.9 19.9 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1645) ATP-synt_E PF05680.12 EXF74062.1 - 4.1 7.8 13.3 4.6 7.7 0.7 2.5 2 0 0 2 2 2 0 ATP synthase E chain CPSF100_C PF13299.6 EXF74062.1 - 6.7 6.9 11.0 4.4 7.5 3.0 2.3 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Matrilin_ccoil PF10393.9 EXF74062.1 - 8.9 6.3 9.1 1.5 8.8 0.7 3.0 2 1 1 3 3 3 0 Trimeric coiled-coil oligomerisation domain of matrilin Pkinase PF00069.25 EXF74063.1 - 1.5e-65 221.2 0.0 2.1e-65 220.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF74063.1 - 3.1e-42 144.7 0.0 4.3e-42 144.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EXF74063.1 - 1.7e-05 24.3 0.0 2.8e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like POLO_box PF00659.18 EXF74063.1 - 2.4e-05 24.4 0.1 0.0044 17.2 0.0 2.8 2 0 0 2 2 2 1 POLO box duplicated region Kdo PF06293.14 EXF74063.1 - 0.0029 17.0 0.0 0.0059 16.0 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EXF74063.1 - 0.021 13.6 0.1 0.043 12.6 0.1 1.4 1 0 0 1 1 1 0 Fungal protein kinase ketoacyl-synt PF00109.26 EXF74064.1 - 4.6e-76 255.8 0.1 1.5e-75 254.1 0.0 2.0 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain PS-DH PF14765.6 EXF74064.1 - 5.6e-49 167.0 0.0 1.1e-48 166.0 0.0 1.6 1 0 0 1 1 1 1 Polyketide synthase dehydratase KR PF08659.10 EXF74064.1 - 3.6e-48 163.8 0.1 1.2e-47 162.1 0.0 2.0 2 0 0 2 2 2 1 KR domain Condensation PF00668.20 EXF74064.1 - 5.8e-48 163.7 0.0 1e-47 162.9 0.0 1.3 1 0 0 1 1 1 1 Condensation domain Acyl_transf_1 PF00698.21 EXF74064.1 - 1.9e-43 149.2 0.1 4e-43 148.1 0.1 1.5 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EXF74064.1 - 1.6e-30 105.5 0.1 4.3e-30 104.1 0.1 1.8 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Methyltransf_12 PF08242.12 EXF74064.1 - 2.1e-19 70.1 0.0 7.9e-19 68.2 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EXF74064.1 - 4.1e-15 56.0 0.0 9.5e-15 54.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain KAsynt_C_assoc PF16197.5 EXF74064.1 - 4.1e-15 56.2 0.0 1.7e-14 54.2 0.0 2.1 2 0 0 2 2 1 1 Ketoacyl-synthetase C-terminal extension Methyltransf_25 PF13649.6 EXF74064.1 - 5.1e-12 46.3 0.0 1.8e-11 44.6 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF74064.1 - 1.3e-10 41.3 0.0 3.4e-10 39.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF74064.1 - 2.9e-10 40.6 0.0 1.3e-09 38.6 0.0 2.2 1 0 0 1 1 1 1 Methyltransferase domain adh_short PF00106.25 EXF74064.1 - 6.7e-08 32.2 0.0 2.8e-07 30.2 0.0 2.1 2 0 0 2 2 2 1 short chain dehydrogenase PP-binding PF00550.25 EXF74064.1 - 2.3e-06 27.9 0.0 6.8e-06 26.4 0.0 1.9 1 0 0 1 1 1 1 Phosphopantetheine attachment site Thiolase_N PF00108.23 EXF74064.1 - 5.2e-05 22.7 0.0 0.00011 21.7 0.0 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain Ubie_methyltran PF01209.18 EXF74064.1 - 0.00091 18.6 0.0 0.0019 17.6 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family ACP_syn_III PF08545.10 EXF74064.1 - 0.043 13.7 0.1 0.3 11.0 0.1 2.5 3 0 0 3 3 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Methyltransf_16 PF10294.9 EXF74064.1 - 0.071 12.9 0.0 0.2 11.4 0.0 1.7 1 0 0 1 1 1 0 Lysine methyltransferase NodS PF05401.11 EXF74064.1 - 0.12 12.0 0.0 0.28 10.8 0.0 1.6 1 0 0 1 1 1 0 Nodulation protein S (NodS) Dodecin PF07311.12 EXF74064.1 - 0.19 12.0 0.2 0.99 9.7 0.2 2.2 1 0 0 1 1 1 0 Dodecin DUF3328 PF11807.8 EXF74065.1 - 2.8e-24 86.1 3.1 2.8e-24 86.1 3.1 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF3328) ADH_N PF08240.12 EXF74066.1 - 2.1e-09 37.2 0.1 8.3e-09 35.3 0.1 2.0 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EXF74066.1 - 3.6e-07 30.2 0.0 8e-07 29.1 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase FSH1 PF03959.13 EXF74067.1 - 9.6e-33 113.6 0.0 1.2e-32 113.3 0.0 1.0 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_2 PF02230.16 EXF74067.1 - 0.0014 18.5 0.3 0.0048 16.7 0.3 1.8 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_6 PF12697.7 EXF74067.1 - 0.025 15.2 1.0 0.047 14.3 0.5 1.5 1 1 1 2 2 2 0 Alpha/beta hydrolase family p450 PF00067.22 EXF74068.1 - 2.5e-55 188.1 0.0 2.9e-55 187.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 PhyH PF05721.13 EXF74070.1 - 4.1e-19 69.7 0.0 6.5e-19 69.0 0.0 1.3 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) APH PF01636.23 EXF74071.1 - 3.9e-10 40.1 0.1 6e-10 39.4 0.1 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 EXF74071.1 - 0.064 12.5 0.0 0.096 12.0 0.0 1.2 1 0 0 1 1 1 0 Ecdysteroid kinase AMP-binding PF00501.28 EXF74072.1 - 5.6e-21 74.6 0.0 7.9e-21 74.1 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme MFS_1 PF07690.16 EXF74073.1 - 0.00022 20.3 0.3 0.00035 19.6 0.3 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily MFS_2 PF13347.6 EXF74074.1 - 1.4e-11 43.6 8.0 1.4e-11 43.6 8.0 2.3 2 0 0 2 2 2 1 MFS/sugar transport protein MFS_1_like PF12832.7 EXF74074.1 - 8.3e-05 21.6 0.0 0.00028 19.9 0.0 2.1 1 1 0 1 1 1 1 MFS_1 like family GWT1 PF06423.12 EXF74074.1 - 0.071 13.2 1.0 0.32 11.1 0.3 2.6 1 1 1 2 2 2 0 GWT1 Glycos_transf_N PF04413.16 EXF74074.1 - 0.11 12.1 0.5 0.25 11.0 0.3 1.7 2 0 0 2 2 2 0 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) DUF3328 PF11807.8 EXF74075.1 - 1.7e-39 135.9 0.0 2.1e-39 135.5 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) DUF3328 PF11807.8 EXF74076.1 - 3e-32 112.2 2.7 4.1e-32 111.7 2.7 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) Sel1 PF08238.12 EXF74077.1 - 4.1e-39 132.1 30.5 2.9e-05 24.6 0.1 7.5 7 0 0 7 7 7 7 Sel1 repeat Chitin_synth_2 PF03142.15 EXF74078.1 - 1.2e-291 968.0 0.2 1.2e-291 968.0 0.2 1.4 2 0 0 2 2 2 1 Chitin synthase Glyco_trans_2_3 PF13632.6 EXF74078.1 - 1.5e-13 51.2 6.2 5.5e-13 49.3 6.2 2.0 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 EXF74078.1 - 1.2e-11 44.9 0.0 7.9e-11 42.3 0.0 2.0 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 EXF74078.1 - 0.00011 21.7 0.0 0.0045 16.5 0.0 2.2 2 0 0 2 2 2 1 Glycosyl transferase family 21 Cyt-b5 PF00173.28 EXF74078.1 - 0.0016 18.6 0.0 1.7 8.9 0.0 2.9 2 1 0 2 2 2 2 Cytochrome b5-like Heme/Steroid binding domain Glycos_transf_2 PF00535.26 EXF74078.1 - 0.01 15.6 0.0 0.043 13.6 0.0 2.0 2 0 0 2 2 2 0 Glycosyl transferase family 2 Metal_resist PF13801.6 EXF74080.1 - 0.15 12.3 0.1 0.26 11.5 0.1 1.3 1 0 0 1 1 1 0 Heavy-metal resistance E1-E2_ATPase PF00122.20 EXF74081.1 - 4.1e-49 166.6 4.6 4.1e-49 166.6 4.6 2.7 4 0 0 4 4 4 1 E1-E2 ATPase Hydrolase PF00702.26 EXF74081.1 - 3e-17 63.6 0.1 9.6e-17 62.0 0.1 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EXF74081.1 - 9.3e-09 34.9 0.1 1.9e-08 33.9 0.1 1.5 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EXF74081.1 - 0.0022 17.8 0.1 0.0046 16.7 0.1 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EXF74081.1 - 0.034 14.2 0.0 0.066 13.3 0.0 1.4 1 0 0 1 1 1 0 Cation transport ATPase (P-type) O-antigen_lig PF13425.6 EXF74081.1 - 0.1 11.4 4.9 0.26 10.1 4.9 1.6 1 0 0 1 1 1 0 O-antigen ligase like membrane protein DUF2613 PF11021.8 EXF74081.1 - 9.4 6.4 7.7 17 5.6 0.4 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2613) Arrestin_C PF02752.22 EXF74082.1 - 0.06 13.8 0.0 0.075 13.5 0.0 1.2 1 0 0 1 1 1 0 Arrestin (or S-antigen), C-terminal domain DUF3425 PF11905.8 EXF74085.1 - 1.7e-21 76.5 2.5 2.6e-21 75.9 2.5 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) bZIP_1 PF00170.21 EXF74085.1 - 0.015 15.4 10.7 0.019 15.1 7.6 2.2 1 1 1 2 2 2 0 bZIP transcription factor TPR_21 PF09976.9 EXF74085.1 - 0.21 11.3 2.3 0.39 10.4 2.3 1.3 1 0 0 1 1 1 0 Tetratricopeptide repeat-like domain SMN PF06003.12 EXF74085.1 - 1.2 8.4 5.8 0.44 9.8 0.5 2.2 2 0 0 2 2 2 0 Survival motor neuron protein (SMN) Spindle_Spc25 PF08234.12 EXF74086.1 - 1.3e-25 89.4 0.1 3.4e-25 88.0 0.1 1.7 1 0 0 1 1 1 1 Chromosome segregation protein Spc25 DUF4407 PF14362.6 EXF74086.1 - 0.057 12.8 12.3 0.078 12.3 12.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Filament PF00038.21 EXF74086.1 - 0.16 11.5 20.2 0.89 9.1 20.2 2.0 1 1 0 1 1 1 0 Intermediate filament protein Atg14 PF10186.9 EXF74086.1 - 0.2 10.7 12.5 0.34 9.9 12.5 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 FapA PF03961.13 EXF74086.1 - 0.27 9.8 7.7 0.37 9.3 7.7 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A UPF0242 PF06785.11 EXF74086.1 - 0.78 9.8 12.5 1.3 9.1 12.5 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Lebercilin PF15619.6 EXF74086.1 - 2.7 7.6 28.2 1 9.0 11.4 2.6 2 1 1 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease Tho2 PF11262.8 EXF74086.1 - 9.7 5.3 12.9 14 4.7 12.6 1.5 1 1 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 MFS_1 PF07690.16 EXF74087.1 - 5.6e-19 68.3 21.1 5.6e-19 68.3 21.1 2.8 1 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF74087.1 - 6.7e-08 31.8 17.6 0.0003 19.8 0.1 3.3 3 1 0 3 3 3 2 Sugar (and other) transporter DUF5389 PF17364.2 EXF74087.1 - 0.0021 18.1 1.9 0.0035 17.4 0.5 2.2 2 0 0 2 2 2 1 Family of unknown function (DUF5389) TssN PF17555.2 EXF74087.1 - 0.29 10.5 2.9 0.67 9.3 2.9 1.7 1 0 0 1 1 1 0 Type VI secretion system, TssN Neurensin PF14927.6 EXF74087.1 - 1.6 8.4 5.6 1.9 8.2 3.4 2.3 2 1 0 2 2 2 0 Neurensin SPX PF03105.19 EXF74088.1 - 3.7e-40 139.0 4.9 5.4e-28 99.0 0.0 2.8 2 1 1 3 3 3 2 SPX domain Na_sulph_symp PF00939.19 EXF74088.1 - 7.3e-36 124.2 39.9 1.1e-35 123.7 39.9 1.1 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 EXF74088.1 - 6.1e-28 97.9 37.0 6.1e-28 97.9 37.0 1.8 2 0 0 2 2 2 1 Citrate transporter Sporozoite_P67 PF05642.11 EXF74088.1 - 0.018 13.1 1.9 0.033 12.3 1.9 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Vps39_1 PF10366.9 EXF74089.1 - 3.3e-33 114.2 0.1 5.6e-32 110.2 0.0 3.2 5 0 0 5 5 5 1 Vacuolar sorting protein 39 domain 1 Vps39_2 PF10367.9 EXF74089.1 - 1e-29 103.2 0.0 3e-29 101.6 0.0 1.9 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 CNH PF00780.22 EXF74089.1 - 9e-19 68.1 0.0 2e-18 67.0 0.0 1.5 1 1 0 1 1 1 1 CNH domain Clathrin PF00637.20 EXF74089.1 - 1.2e-07 31.7 0.4 0.00016 21.6 0.7 3.2 3 0 0 3 3 3 2 Region in Clathrin and VPS Clathrin_H_link PF13838.6 EXF74089.1 - 0.16 11.9 0.0 2.3 8.2 0.0 2.5 2 0 0 2 2 2 0 Clathrin-H-link TPR_1 PF00515.28 EXF74089.1 - 2.1 8.3 7.0 5 7.1 0.2 4.2 5 0 0 5 5 5 0 Tetratricopeptide repeat Gon7 PF08738.10 EXF74090.1 - 3e-10 40.2 2.8 8.4e-10 38.7 0.5 2.0 1 1 1 2 2 2 1 Gon7 family PSK_trans_fac PF07704.11 EXF74090.1 - 0.034 14.9 0.7 0.086 13.6 0.2 1.8 1 1 1 2 2 2 0 Rv0623-like transcription factor DUF3987 PF13148.6 EXF74090.1 - 0.098 11.7 1.6 0.094 11.7 1.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) HbrB PF08539.11 EXF74091.1 - 1.7e-55 187.6 0.0 1.7e-55 187.6 0.0 2.2 3 0 0 3 3 3 1 HbrB-like LIM_bind PF01803.16 EXF74092.1 - 3.3e-76 256.0 0.0 3.3e-76 256.0 0.0 4.9 3 1 1 4 4 4 1 LIM-domain binding protein Neisseria_TspB PF05616.13 EXF74092.1 - 0.49 8.8 12.6 1 7.7 12.6 1.5 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein DUF688 PF05097.12 EXF74093.1 - 0.036 13.2 0.9 0.087 12.0 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF688) FANC_SAP PF18081.1 EXF74093.1 - 0.14 12.3 0.1 0.31 11.2 0.1 1.5 1 0 0 1 1 1 0 Fanconi anemia-associated nuclease SAP domain SNARE PF05739.19 EXF74094.1 - 4.3e-09 36.2 1.8 8e-09 35.4 1.8 1.5 1 0 0 1 1 1 1 SNARE domain Fusion_gly PF00523.18 EXF74094.1 - 0.1 10.8 0.2 0.15 10.3 0.2 1.2 1 0 0 1 1 1 0 Fusion glycoprotein F0 ANAPC4_WD40 PF12894.7 EXF74095.1 - 0.0049 17.1 0.0 2 8.7 0.0 3.4 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EXF74095.1 - 0.0099 16.7 3.6 0.1 13.5 0.1 3.7 5 0 0 5 5 5 1 WD domain, G-beta repeat PPTA PF01239.22 EXF74096.1 - 1e-39 133.1 11.1 3.7e-08 32.8 0.1 5.4 5 0 0 5 5 5 5 Protein prenyltransferase alpha subunit repeat HSP70 PF00012.20 EXF74099.1 - 3.6e-10 38.7 0.4 2.1e-09 36.1 0.2 1.9 2 0 0 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.13 EXF74099.1 - 0.017 14.0 0.1 0.076 11.8 0.0 1.8 2 0 0 2 2 2 0 MreB/Mbl protein Thaumatin PF00314.17 EXF74100.1 - 3.2e-66 223.0 5.1 4.5e-66 222.6 5.1 1.2 1 0 0 1 1 1 1 Thaumatin family Glyco_hydro_64 PF16483.5 EXF74100.1 - 0.14 11.4 0.1 11 5.2 0.0 2.2 2 0 0 2 2 2 0 Beta-1,3-glucanase BRCT_2 PF16589.5 EXF74101.1 - 3e-06 27.5 0.0 5.6e-06 26.7 0.0 1.5 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain PTCB-BRCT PF12738.7 EXF74101.1 - 0.00016 21.5 0.2 0.0007 19.5 0.0 2.0 2 0 0 2 2 2 1 twin BRCT domain LIG3_BRCT PF16759.5 EXF74101.1 - 0.011 15.9 0.0 0.079 13.3 0.0 2.2 2 0 0 2 2 2 0 DNA ligase 3 BRCT domain Ribosomal_60s PF00428.19 EXF74101.1 - 0.066 13.8 1.8 0.27 11.8 2.0 1.9 2 0 0 2 2 2 0 60s Acidic ribosomal protein AMP-binding PF00501.28 EXF74102.1 - 8.7e-72 242.0 0.0 1e-71 241.8 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme ACAS_N PF16177.5 EXF74102.1 - 5.3e-19 67.9 0.4 5.3e-19 67.9 0.4 2.4 3 0 0 3 3 3 1 Acetyl-coenzyme A synthetase N-terminus AMP-binding_C PF13193.6 EXF74102.1 - 2.3e-17 63.7 0.0 6.3e-17 62.3 0.0 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain ADH_zinc_N PF00107.26 EXF74104.1 - 7e-26 90.7 0.3 1.1e-25 90.1 0.3 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EXF74104.1 - 3.5e-21 76.6 0.0 5.4e-21 76.0 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EXF74104.1 - 1.1e-08 34.9 0.0 2.5e-07 30.6 0.0 2.4 1 1 1 2 2 2 2 Alcohol dehydrogenase GroES-like domain CFEM PF05730.11 EXF74105.1 - 6.7e-07 29.3 3.5 6.7e-07 29.3 3.5 1.7 2 0 0 2 2 2 1 CFEM domain DLH PF01738.18 EXF74106.1 - 1.4e-20 73.8 0.0 9.8e-10 38.3 0.0 2.3 2 0 0 2 2 2 2 Dienelactone hydrolase family Rep_fac-A_C PF08646.10 EXF74107.1 - 4.7e-57 191.8 5.7 4.2e-56 188.8 3.5 2.4 2 0 0 2 2 2 1 Replication factor-A C terminal domain REPA_OB_2 PF16900.5 EXF74107.1 - 6.1e-39 131.9 1.9 2.6e-38 129.9 0.5 2.6 3 0 0 3 3 3 1 Replication protein A OB domain Rep-A_N PF04057.12 EXF74107.1 - 2.6e-24 85.1 0.1 6.4e-24 83.9 0.1 1.7 1 0 0 1 1 1 1 Replication factor-A protein 1, N-terminal domain tRNA_anti-codon PF01336.25 EXF74107.1 - 6.4e-16 58.1 0.9 6.4e-10 38.9 0.0 4.4 4 1 1 5 5 5 2 OB-fold nucleic acid binding domain CDC24_OB3 PF17244.2 EXF74107.1 - 0.00062 19.5 0.6 0.029 14.1 0.1 2.7 3 0 0 3 3 3 1 Cell division control protein 24, OB domain 3 DUF5521 PF17659.1 EXF74107.1 - 0.076 10.8 1.4 0.6 7.9 0.1 2.5 2 1 0 2 2 2 0 Family of unknown function (DUF5521) DUF4539 PF15072.6 EXF74107.1 - 0.078 13.0 0.0 3.2 7.9 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4539) DUF4957 PF16318.5 EXF74107.1 - 2.1 8.3 4.7 1.9 8.4 0.4 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4957) PCI PF01399.27 EXF74108.1 - 0.014 15.9 0.1 0.082 13.4 0.0 2.2 2 0 0 2 2 2 0 PCI domain Amidohydro_1 PF01979.20 EXF74109.1 - 5.6e-05 22.6 1.1 0.00024 20.6 1.1 1.8 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_2 PF04909.14 EXF74109.1 - 0.00043 20.2 0.0 0.00075 19.4 0.0 1.4 1 0 0 1 1 1 1 Amidohydrolase TatD_DNase PF01026.21 EXF74109.1 - 0.039 13.3 0.1 0.12 11.8 0.1 1.8 1 1 0 1 1 1 0 TatD related DNase zf-PHD-like PF15446.6 EXF74111.1 - 1.8e-70 236.0 12.4 5.7e-70 234.3 12.4 2.0 1 0 0 1 1 1 1 PHD/FYVE-zinc-finger like domain SNF2_N PF00176.23 EXF74111.1 - 1.1e-49 169.1 0.3 6.4e-49 166.5 0.3 1.9 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EXF74111.1 - 6.4e-20 71.6 0.0 1.9e-19 70.0 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HDA2-3 PF11496.8 EXF74111.1 - 1.2e-13 50.9 1.1 3.4e-13 49.4 1.1 1.7 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 ResIII PF04851.15 EXF74111.1 - 1e-06 28.8 0.0 2.4e-06 27.6 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit PHD PF00628.29 EXF74111.1 - 1.8e-05 24.5 2.5 1.8e-05 24.5 2.5 3.4 2 1 1 3 3 3 2 PHD-finger Chromo PF00385.24 EXF74111.1 - 6.7e-05 22.7 1.5 0.0015 18.4 1.0 2.9 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain PHD_2 PF13831.6 EXF74111.1 - 0.00049 19.6 4.3 0.00068 19.1 0.4 2.8 2 0 0 2 2 2 1 PHD-finger Zf_RING PF16744.5 EXF74111.1 - 0.072 13.2 10.1 0.054 13.6 0.9 2.6 2 0 0 2 2 2 0 KIAA1045 RING finger SpoU_methylase PF00588.19 EXF74112.1 - 5.8e-27 94.6 0.0 9.1e-27 94.0 0.0 1.3 1 0 0 1 1 1 1 SpoU rRNA Methylase family SpoU_sub_bind PF08032.12 EXF74112.1 - 6.4e-11 42.4 0.0 1.4e-10 41.3 0.0 1.6 1 0 0 1 1 1 1 RNA 2'-O ribose methyltransferase substrate binding Arginase PF00491.21 EXF74115.1 - 5.1e-91 305.0 0.0 6.7e-91 304.7 0.0 1.1 1 0 0 1 1 1 1 Arginase family UPF0489 PF12640.7 EXF74115.1 - 0.083 13.1 0.0 0.14 12.4 0.0 1.3 1 0 0 1 1 1 0 UPF0489 domain DUF1589 PF07628.11 EXF74115.1 - 0.15 12.1 0.0 0.8 9.8 0.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1589) zf-U1 PF06220.12 EXF74117.1 - 6.3e-22 77.1 3.4 9.3e-22 76.5 3.4 1.3 1 0 0 1 1 1 1 U1 zinc finger EMP24_GP25L PF01105.24 EXF74118.1 - 3.1e-41 141.3 0.0 3.8e-41 141.0 0.0 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DUF4164 PF13747.6 EXF74118.1 - 0.016 15.5 0.4 0.025 14.8 0.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) EzrA PF06160.12 EXF74118.1 - 0.087 11.0 0.9 0.11 10.6 0.9 1.0 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA Sdh5 PF03937.16 EXF74119.1 - 1.2e-23 82.9 0.3 3.4e-23 81.4 0.2 1.7 2 0 0 2 2 2 1 Flavinator of succinate dehydrogenase RAP1 PF07218.11 EXF74119.1 - 0.13 10.5 3.2 0.16 10.3 3.2 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) MIS13 PF08202.11 EXF74120.1 - 4.5e-60 203.5 2.4 9.1e-60 202.5 2.4 1.5 1 0 0 1 1 1 1 Mis12-Mtw1 protein family RNA_pol_Rpb4 PF03874.16 EXF74120.1 - 0.035 14.4 0.4 0.11 12.8 0.4 1.9 1 1 0 1 1 1 0 RNA polymerase Rpb4 DUF5082 PF16888.5 EXF74120.1 - 0.041 14.2 2.7 0.4 11.0 2.7 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF5082) DUF2750 PF11042.8 EXF74120.1 - 0.087 12.9 0.1 0.15 12.1 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2750) Trypan_PARP PF05887.11 EXF74120.1 - 0.17 11.9 36.6 0.34 10.9 12.3 2.4 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) DUF2205 PF10224.9 EXF74120.1 - 3.3 7.8 5.1 1.2 9.1 0.3 2.4 2 0 0 2 2 2 0 Short coiled-coil protein Aft1_HRA PF11786.8 EXF74121.1 - 6.6e-24 84.0 10.0 6.6e-24 84.0 10.0 3.0 3 1 0 3 3 3 1 Aft1 HRA domain Aft1_HRR PF11787.8 EXF74121.1 - 7e-24 84.8 18.1 7e-24 84.8 18.1 4.2 5 1 0 5 5 5 1 Aft1 HRR domain Aft1_OSA PF11785.8 EXF74121.1 - 3.1e-20 72.4 7.1 3.1e-20 72.4 7.1 5.4 6 0 0 6 6 6 1 Aft1 osmotic stress response (OSM) domain bZIP_1 PF00170.21 EXF74121.1 - 1.4e-12 47.5 6.2 2.3e-12 46.8 6.2 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EXF74121.1 - 9.1e-06 25.7 6.2 9.1e-06 25.7 6.2 1.7 2 0 0 2 2 2 1 Basic region leucine zipper bZIP_Maf PF03131.17 EXF74121.1 - 0.0028 18.1 2.9 0.0028 18.1 2.9 2.3 2 0 0 2 2 2 1 bZIP Maf transcription factor Pannexin_like PF12534.8 EXF74121.1 - 0.52 9.4 2.1 1.1 8.3 2.1 1.4 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 GST_N_3 PF13417.6 EXF74122.1 - 2.5e-09 37.4 0.1 5e-09 36.5 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EXF74122.1 - 5.6e-05 23.1 0.2 9.4e-05 22.4 0.2 1.5 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EXF74122.1 - 0.00011 22.4 0.0 0.00018 21.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 EXF74122.1 - 0.00018 21.7 0.1 0.00053 20.2 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain DUF150_C PF17384.2 EXF74122.1 - 0.031 14.4 0.0 0.27 11.4 0.0 2.5 3 0 0 3 3 3 0 RimP C-terminal SH3 domain p450 PF00067.22 EXF74123.1 - 1.2e-45 156.1 0.0 2.2e-38 132.2 0.0 2.1 2 0 0 2 2 2 2 Cytochrome P450 CDT1_C PF16679.5 EXF74124.1 - 4.6e-19 68.6 0.1 4.6e-19 68.6 0.1 2.5 3 0 0 3 3 3 1 DNA replication factor Cdt1 C-terminal domain MBF1 PF08523.10 EXF74125.1 - 3.6e-27 94.6 2.1 6.9e-27 93.7 2.1 1.5 1 0 0 1 1 1 1 Multiprotein bridging factor 1 HTH_3 PF01381.22 EXF74125.1 - 8.4e-11 41.8 0.0 1.5e-10 41.0 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix MRP-L27 PF09809.9 EXF74125.1 - 0.0098 15.7 0.0 0.013 15.3 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L27 HTH_31 PF13560.6 EXF74125.1 - 0.013 15.8 0.0 0.027 14.8 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain WLM PF08325.10 EXF74127.1 - 4.5e-57 193.2 0.0 8.5e-57 192.3 0.0 1.4 1 0 0 1 1 1 1 WLM domain Peptidase_M54 PF07998.11 EXF74127.1 - 0.14 12.1 0.0 0.21 11.6 0.0 1.2 1 0 0 1 1 1 0 Peptidase family M54 Asp PF00026.23 EXF74128.1 - 5e-69 233.1 7.3 5.9e-69 232.9 7.3 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EXF74128.1 - 1.1e-10 42.1 4.5 1.6e-08 35.0 4.5 2.3 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal PLA2_B PF01735.18 EXF74130.1 - 6.5e-193 641.6 0.2 7.5e-193 641.4 0.2 1.0 1 0 0 1 1 1 1 Lysophospholipase catalytic domain SWIRM-assoc_2 PF16496.5 EXF74131.1 - 0.0027 16.7 0.6 0.0027 16.7 0.6 3.8 3 1 1 4 4 4 1 SWIRM-associated domain at the N-terminal PTCB-BRCT PF12738.7 EXF74131.1 - 0.087 12.8 0.1 2 8.4 0.0 2.3 2 0 0 2 2 2 0 twin BRCT domain HHH_8 PF14716.6 EXF74133.1 - 0.12 12.8 1.5 0.17 12.2 0.7 1.7 2 0 0 2 2 2 0 Helix-hairpin-helix domain DAHP_synth_2 PF01474.16 EXF74134.1 - 9.2e-202 670.3 0.0 1.1e-201 670.1 0.0 1.0 1 0 0 1 1 1 1 Class-II DAHP synthetase family Amidase PF01425.21 EXF74135.1 - 6.9e-95 318.6 0.0 1.1e-94 318.0 0.0 1.3 1 1 0 1 1 1 1 Amidase UPF0180 PF03698.13 EXF74135.1 - 0.13 12.4 0.0 0.31 11.2 0.0 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0180) Methyltransf_25 PF13649.6 EXF74136.1 - 3e-14 53.5 0.0 1.4e-13 51.3 0.0 2.1 3 0 0 3 3 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF74136.1 - 6e-13 48.9 0.0 8.3e-13 48.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF74136.1 - 4e-09 37.0 0.0 2.6e-08 34.4 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain PCMT PF01135.19 EXF74136.1 - 3.7e-07 30.1 0.3 7.1e-07 29.2 0.0 1.5 2 0 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_12 PF08242.12 EXF74136.1 - 4.4e-07 30.6 0.0 9.2e-07 29.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EXF74136.1 - 3.4e-05 23.8 0.0 5.2e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EXF74136.1 - 7.8e-05 22.3 0.0 0.00013 21.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Ubie_methyltran PF01209.18 EXF74136.1 - 0.00051 19.5 0.0 0.00072 19.0 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_32 PF13679.6 EXF74136.1 - 0.00054 20.0 0.0 0.00075 19.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.18 EXF74136.1 - 0.0013 18.4 0.0 0.03 14.0 0.0 2.4 2 1 0 2 2 2 1 Putative RNA methylase family UPF0020 PrmA PF06325.13 EXF74136.1 - 0.0018 17.7 0.2 0.0028 17.1 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) RrnaAD PF00398.20 EXF74136.1 - 0.023 13.8 0.0 0.032 13.3 0.0 1.1 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Methyltransf_18 PF12847.7 EXF74136.1 - 0.023 14.6 0.0 0.037 13.9 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_9 PF08003.11 EXF74136.1 - 0.08 11.8 0.0 0.13 11.2 0.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1698) NAD_binding_6 PF08030.12 EXF74137.1 - 1.4e-23 83.7 0.0 2.1e-23 83.1 0.0 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EXF74137.1 - 1.1e-22 80.2 0.0 2.4e-22 79.1 0.0 1.6 1 0 0 1 1 1 1 FAD-binding domain Ferric_reduct PF01794.19 EXF74137.1 - 1.6e-18 67.0 10.5 1.6e-18 67.0 10.5 2.3 1 1 1 2 2 2 1 Ferric reductase like transmembrane component NADH_u_ox_C PF12853.7 EXF74138.1 - 0.058 13.4 0.1 0.1 12.6 0.1 1.3 1 0 0 1 1 1 0 C-terminal of NADH-ubiquinone oxidoreductase 21 kDa subunit DUF5357 PF17310.2 EXF74138.1 - 1 7.9 2.9 0.91 8.0 0.9 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5357) F-box-like PF12937.7 EXF74139.1 - 4.8e-08 32.8 0.4 9.3e-08 31.8 0.4 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EXF74139.1 - 3.8e-06 26.6 0.7 9.1e-06 25.4 0.7 1.6 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 EXF74139.1 - 0.04 13.8 0.0 0.091 12.6 0.0 1.5 1 0 0 1 1 1 0 F-box Myosin_head PF00063.21 EXF74140.1 - 3.5e-239 795.5 2.5 4.2e-239 795.3 2.5 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.13 EXF74140.1 - 9.6e-49 165.6 0.0 2e-48 164.5 0.0 1.6 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding SH3_1 PF00018.28 EXF74140.1 - 1.9e-13 49.8 0.2 3.7e-13 48.8 0.2 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EXF74140.1 - 9.3e-12 44.6 0.1 2.1e-11 43.5 0.1 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EXF74140.1 - 9.7e-09 34.8 0.0 3e-08 33.2 0.0 1.9 1 0 0 1 1 1 1 Variant SH3 domain IQ PF00612.27 EXF74140.1 - 0.005 16.5 10.0 0.17 11.7 2.4 2.7 1 1 1 2 2 2 2 IQ calmodulin-binding motif AAA_22 PF13401.6 EXF74140.1 - 0.046 14.0 0.0 0.13 12.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain Hpr_kinase_C PF07475.12 EXF74140.1 - 0.087 12.3 0.3 5.2 6.6 0.0 2.3 2 0 0 2 2 2 0 HPr Serine kinase C-terminal domain DUF4913 PF16259.5 EXF74140.1 - 0.099 12.7 0.9 0.34 11.0 0.9 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4913) AAA_16 PF13191.6 EXF74140.1 - 0.11 12.8 0.0 0.31 11.4 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.27 EXF74140.1 - 0.15 12.5 0.0 0.52 10.8 0.0 1.9 1 0 0 1 1 1 0 ABC transporter NACHT PF05729.12 EXF74140.1 - 0.16 11.8 0.0 0.38 10.7 0.0 1.6 1 0 0 1 1 1 0 NACHT domain DHHC PF01529.20 EXF74141.1 - 1.4e-17 64.1 23.0 3.1e-13 50.0 0.9 2.5 3 0 0 3 3 3 2 DHHC palmitoyltransferase Ribosomal_L40e PF01020.17 EXF74141.1 - 2.3 8.2 8.2 4.2 7.3 8.2 1.4 1 0 0 1 1 1 0 Ribosomal L40e family Glyco_transf_90 PF05686.12 EXF74142.1 - 5.3e-07 28.9 0.0 0.00061 18.8 0.0 3.3 2 1 0 2 2 2 2 Glycosyl transferase family 90 Aldose_epim PF01263.20 EXF74143.1 - 4.2e-38 131.4 0.0 4.7e-38 131.2 0.0 1.0 1 0 0 1 1 1 1 Aldose 1-epimerase Rif1_N PF12231.8 EXF74144.1 - 1.6e-139 465.1 1.5 2.5e-139 464.4 1.5 1.3 1 0 0 1 1 1 1 Rap1-interacting factor 1 N terminal Gcn1_N PF12074.8 EXF74144.1 - 0.0024 17.2 0.1 0.021 14.1 0.0 2.1 2 0 0 2 2 2 1 Generalcontrol nonderepressible 1 (Gcn1) N-terminal RasGAP PF00616.19 EXF74144.1 - 0.32 10.7 2.6 0.62 9.7 0.0 2.8 4 0 0 4 4 4 0 GTPase-activator protein for Ras-like GTPase Ric8 PF10165.9 EXF74145.1 - 3.1e-129 432.0 0.1 3.7e-129 431.8 0.1 1.1 1 0 0 1 1 1 1 Guanine nucleotide exchange factor synembryn VGPC1_C PF16799.5 EXF74145.1 - 0.043 13.8 0.2 0.12 12.3 0.2 1.8 1 0 0 1 1 1 0 C-terminal membrane-localisation domain of ion-channel, VCN1 AT_hook PF02178.19 EXF74146.1 - 0.033 14.0 6.4 0.13 12.2 6.4 2.1 1 0 0 1 1 1 0 AT hook motif PQ-loop PF04193.14 EXF74147.1 - 7e-21 73.8 4.1 3.9e-11 42.5 1.0 2.5 2 0 0 2 2 2 2 PQ loop repeat SprT-like PF10263.9 EXF74149.1 - 2.1e-15 56.5 0.1 4.4e-15 55.5 0.1 1.6 1 0 0 1 1 1 1 SprT-like family SprT-like PF10263.9 EXF74150.1 - 0.081 12.8 0.2 0.27 11.1 0.1 2.2 2 1 0 2 2 2 0 SprT-like family NnrU PF07298.11 EXF74152.1 - 0.013 15.0 4.4 0.79 9.2 0.4 2.4 2 1 0 2 2 2 0 NnrU protein Ycf4 PF02392.16 EXF74152.1 - 1.4 8.5 4.9 0.7 9.4 1.4 2.0 2 0 0 2 2 2 0 Ycf4 Sortilin-Vps10 PF15902.5 EXF74153.1 - 1.2e-294 976.9 26.0 3.9e-152 507.1 11.7 2.1 2 0 0 2 2 2 2 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.5 EXF74153.1 - 3.8e-90 300.7 36.7 1.2e-49 168.9 10.3 3.3 3 0 0 3 3 3 2 Sortilin, neurotensin receptor 3, C-terminal BNR PF02012.20 EXF74153.1 - 7.6e-12 43.4 42.1 0.41 10.8 0.1 11.3 10 0 0 10 10 10 7 BNR/Asp-box repeat PSII_BNR PF14870.6 EXF74153.1 - 2.2e-05 23.9 6.5 0.37 10.0 0.0 5.5 4 1 1 5 5 5 2 Photosynthesis system II assembly factor YCF48 CHB_HEX_C PF03174.13 EXF74153.1 - 0.00031 20.7 3.0 0.71 9.9 0.1 4.4 4 0 0 4 4 4 2 Chitobiase/beta-hexosaminidase C-terminal domain DUF2561 PF10812.8 EXF74153.1 - 0.058 13.4 0.0 0.11 12.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2561) preSET_CXC PF18264.1 EXF74153.1 - 0.89 10.1 9.4 3.4 8.2 0.7 2.7 2 0 0 2 2 2 0 CXC domain Mago-bind PF09282.10 EXF74154.1 - 1.4e-14 53.6 3.1 2.6e-14 52.8 3.1 1.5 1 0 0 1 1 1 1 Mago binding Nucleo_P87 PF07267.11 EXF74154.1 - 0.13 11.1 3.2 0.13 11.1 3.2 1.0 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 RR_TM4-6 PF06459.12 EXF74154.1 - 0.39 10.5 7.0 0.49 10.2 7.0 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF4407 PF14362.6 EXF74154.1 - 0.52 9.6 5.3 0.53 9.6 5.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) NPR3 PF03666.13 EXF74154.1 - 7.6 5.2 6.2 8.5 5.0 6.2 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Presenilin PF01080.17 EXF74154.1 - 7.9 5.1 4.8 9.5 4.9 4.8 1.1 1 0 0 1 1 1 0 Presenilin Cation_ATPase_C PF00689.21 EXF74155.1 - 6.8e-45 153.0 3.7 6.8e-45 153.0 3.7 2.5 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 EXF74155.1 - 5.8e-39 133.5 0.4 5.8e-39 133.5 0.4 2.7 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase PF13246.6 EXF74155.1 - 1.3e-22 79.7 0.0 2.6e-22 78.7 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EXF74155.1 - 1.6e-18 67.8 0.1 3.8e-18 66.5 0.1 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EXF74155.1 - 1.9e-07 30.6 0.2 7.2e-07 28.8 0.0 2.1 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EXF74155.1 - 1.2e-05 25.2 0.2 0.00083 19.2 0.2 2.5 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 EXF74155.1 - 0.037 14.4 0.0 0.11 12.9 0.0 1.8 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Viral_Beta_CD PF04530.12 EXF74155.1 - 0.093 13.0 0.0 1 9.7 0.0 2.5 2 0 0 2 2 2 0 Viral Beta C/D like family DUF2976 PF11190.8 EXF74155.1 - 0.68 9.8 8.0 1.6 8.6 0.6 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2976) UCR_UQCRX_QCR9 PF05365.12 EXF74156.1 - 1e-22 79.8 2.3 1.3e-22 79.5 2.3 1.1 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like Ribonuc_L-PSP PF01042.21 EXF74157.1 - 3.5e-41 140.0 0.0 4.3e-41 139.7 0.0 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP PMT PF02366.18 EXF74158.1 - 1.7e-84 283.2 16.1 3e-84 282.4 16.1 1.4 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 EXF74158.1 - 3.2e-70 235.8 4.6 3.2e-70 235.8 4.6 2.8 2 1 0 3 3 3 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 EXF74158.1 - 5.3e-21 75.3 0.5 1.5e-20 73.8 0.2 1.7 1 1 1 2 2 2 2 MIR domain RAMP4 PF06624.12 EXF74158.1 - 0.019 15.0 0.4 0.72 10.0 0.2 2.7 2 0 0 2 2 2 0 Ribosome associated membrane protein RAMP4 DUF334 PF03904.13 EXF74158.1 - 1.5 8.3 2.7 0.67 9.5 0.2 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF334) CAP59_mtransfer PF11735.8 EXF74159.1 - 4.2e-82 275.5 0.0 5.1e-82 275.2 0.0 1.1 1 0 0 1 1 1 1 Cryptococcal mannosyltransferase 1 Retro_M PF02813.14 EXF74159.1 - 0.13 12.7 0.0 0.3 11.5 0.0 1.5 1 0 0 1 1 1 0 Retroviral M domain zf-C2H2 PF00096.26 EXF74162.1 - 0.0082 16.6 2.7 0.0082 16.6 2.7 2.7 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-H2C2_5 PF13909.6 EXF74162.1 - 0.04 13.7 0.4 0.04 13.7 0.4 2.9 3 0 0 3 3 3 0 C2H2-type zinc-finger domain Pkinase PF00069.25 EXF74163.1 - 2.7e-12 46.6 0.0 4.1e-12 46.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.6 EXF74163.1 - 0.00014 21.3 0.0 0.00023 20.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_Tyr PF07714.17 EXF74163.1 - 0.00015 21.1 0.0 0.00028 20.2 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase DUF4148 PF13663.6 EXF74164.1 - 0.11 12.7 0.0 0.29 11.3 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4148) AAA PF00004.29 EXF74165.1 - 1.3e-07 32.1 2.4 9.2e-07 29.3 1.1 2.7 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EXF74165.1 - 0.0012 19.3 0.0 0.0033 17.8 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EXF74165.1 - 0.0019 18.5 0.7 0.011 16.0 0.1 2.5 2 1 0 2 2 2 1 AAA domain Rad17 PF03215.15 EXF74165.1 - 0.0026 17.7 0.0 0.074 13.0 0.0 2.5 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_18 PF13238.6 EXF74165.1 - 0.0041 17.7 0.0 0.012 16.1 0.0 1.8 1 1 0 1 1 1 1 AAA domain TIP49 PF06068.13 EXF74165.1 - 0.016 14.4 0.0 0.026 13.7 0.0 1.2 1 0 0 1 1 1 0 TIP49 P-loop domain TsaE PF02367.17 EXF74165.1 - 0.04 13.9 0.1 0.11 12.5 0.0 1.7 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE T2SSE PF00437.20 EXF74165.1 - 0.056 12.5 0.0 0.13 11.2 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_14 PF13173.6 EXF74165.1 - 0.15 12.1 0.0 0.47 10.5 0.0 1.7 2 0 0 2 2 2 0 AAA domain F-box-like PF12937.7 EXF74165.1 - 0.16 11.9 0.0 0.33 10.9 0.0 1.5 1 0 0 1 1 1 0 F-box-like AT_hook PF02178.19 EXF74165.1 - 0.36 10.8 6.5 2 8.6 6.5 2.4 1 0 0 1 1 1 0 AT hook motif Utp8 PF10395.9 EXF74166.1 - 2.2e-08 33.1 0.0 0.00017 20.3 0.0 3.2 3 0 0 3 3 3 3 Utp8 family 4HB_MCP_1 PF12729.7 EXF74167.1 - 0.015 14.8 0.3 0.038 13.5 0.1 1.8 2 0 0 2 2 2 0 Four helix bundle sensory module for signal transduction SesA PF17107.5 EXF74167.1 - 0.085 13.0 0.1 0.18 12.0 0.1 1.4 1 0 0 1 1 1 0 N-terminal domain on NACHT_NTPase and P-loop NTPases PTCB-BRCT PF12738.7 EXF74168.1 - 4.3e-45 151.5 0.1 3.6e-20 71.7 0.0 4.4 4 0 0 4 4 4 3 twin BRCT domain BRCT PF00533.26 EXF74168.1 - 1.4e-36 124.7 0.1 2.9e-11 43.6 0.0 4.7 4 1 0 4 4 4 4 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EXF74168.1 - 7e-18 64.8 0.5 0.00069 20.0 0.0 4.7 5 0 0 5 5 5 4 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 EXF74168.1 - 2.4e-07 31.0 0.2 0.27 11.5 0.0 3.7 3 0 0 3 3 3 2 DNA ligase 3 BRCT domain BRCT_3 PF18428.1 EXF74168.1 - 9.1e-05 22.5 0.2 0.11 12.6 0.0 3.6 4 0 0 4 4 4 1 BRCA1 C Terminus (BRCT) domain Cullin_binding PF03556.15 EXF74169.1 - 8.8e-35 119.7 7.0 1.6e-34 118.9 7.0 1.4 1 0 0 1 1 1 1 Cullin binding UBA_4 PF14555.6 EXF74169.1 - 3.5e-10 39.5 0.0 7e-10 38.6 0.0 1.6 1 0 0 1 1 1 1 UBA-like domain HECW1_helix PF18436.1 EXF74169.1 - 0.17 12.0 0.0 1 9.5 0.0 2.1 2 0 0 2 2 2 0 Helical box domain of E3 ubiquitin-protein ligase HECW1 Ribosomal_S6 PF01250.17 EXF74170.1 - 1.7e-23 82.7 0.0 2e-23 82.5 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S6 SQS_PSY PF00494.19 EXF74171.1 - 3.4e-59 200.5 0.5 4e-59 200.3 0.5 1.1 1 0 0 1 1 1 1 Squalene/phytoene synthase SNF2_N PF00176.23 EXF74172.1 - 2.6e-78 263.2 0.1 3.7e-78 262.7 0.1 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain HIRAN PF08797.11 EXF74172.1 - 1.8e-24 85.5 0.0 3.7e-24 84.5 0.0 1.6 1 0 0 1 1 1 1 HIRAN domain Helicase_C PF00271.31 EXF74172.1 - 5.5e-16 58.9 0.0 1.3e-15 57.7 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EXF74172.1 - 3e-06 27.4 0.0 6.5e-06 26.3 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit zf-C3HC4 PF00097.25 EXF74172.1 - 3e-06 27.0 10.9 5.6e-06 26.1 10.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EXF74172.1 - 6.7e-05 23.1 10.2 0.00017 21.9 10.2 1.7 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 EXF74172.1 - 0.00013 21.8 8.2 0.00023 21.0 8.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EXF74172.1 - 0.0015 18.3 11.1 0.0032 17.3 11.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) UBA_4 PF14555.6 EXF74172.1 - 0.0018 18.0 0.1 0.0052 16.6 0.1 1.8 1 0 0 1 1 1 1 UBA-like domain zf-RING_UBOX PF13445.6 EXF74172.1 - 0.0054 16.7 7.4 0.011 15.7 7.4 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 EXF74172.1 - 0.039 13.9 9.4 0.11 12.5 9.5 1.8 1 1 0 1 1 1 0 zinc-RING finger domain ERCC3_RAD25_C PF16203.5 EXF74172.1 - 0.061 12.5 0.2 0.13 11.5 0.2 1.5 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase Prok-RING_4 PF14447.6 EXF74172.1 - 0.085 12.7 7.5 0.48 10.3 7.8 2.1 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 PhnA_Zn_Ribbon PF08274.12 EXF74172.1 - 0.35 10.9 2.2 0.5 10.4 0.0 2.2 2 0 0 2 2 2 0 PhnA Zinc-Ribbon zf-C3HC4_4 PF15227.6 EXF74172.1 - 4 7.7 8.8 8.4 6.6 8.8 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING CDC45 PF02724.14 EXF74173.1 - 3.1 6.0 7.7 3.9 5.6 7.7 1.1 1 0 0 1 1 1 0 CDC45-like protein SKG6 PF08693.10 EXF74175.1 - 0.003 16.9 0.8 0.006 16.0 0.8 1.5 1 0 0 1 1 1 1 Transmembrane alpha-helix domain SARAF PF06682.12 EXF74175.1 - 0.011 15.3 0.0 0.014 15.0 0.0 1.1 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Amnionless PF14828.6 EXF74175.1 - 0.017 14.0 0.0 0.023 13.5 0.0 1.1 1 0 0 1 1 1 0 Amnionless DUF4703 PF15775.5 EXF74175.1 - 0.037 13.8 0.7 0.056 13.2 0.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4703) Shisa PF13908.6 EXF74175.1 - 0.12 12.6 0.0 0.19 12.0 0.0 1.3 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator HemY_N PF07219.13 EXF74175.1 - 0.12 12.5 0.1 0.17 12.1 0.1 1.2 1 0 0 1 1 1 0 HemY protein N-terminus DUF5305 PF17231.2 EXF74175.1 - 0.16 11.3 0.0 0.21 10.9 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5305) Cucumo_2B PF03263.13 EXF74175.1 - 1.6 9.2 4.4 2.5 8.6 4.4 1.2 1 0 0 1 1 1 0 Cucumovirus protein 2B zf-RING_2 PF13639.6 EXF74176.1 - 0.004 17.5 4.1 0.004 17.5 4.1 1.9 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.6 EXF74176.1 - 0.21 11.5 4.3 0.27 11.1 2.0 2.1 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) SnoaL_4 PF13577.6 EXF74177.1 - 2.7e-10 40.4 0.0 3.7e-10 40.0 0.0 1.2 1 0 0 1 1 1 1 SnoaL-like domain CMD PF02627.20 EXF74177.1 - 0.13 12.3 0.0 0.21 11.7 0.0 1.3 1 0 0 1 1 1 0 Carboxymuconolactone decarboxylase family Glyco_hydro_17 PF00332.18 EXF74178.1 - 7e-11 42.3 0.7 9.1e-11 41.9 0.7 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 17 Sugar_tr PF00083.24 EXF74179.1 - 1.3e-87 294.6 19.5 1.6e-87 294.3 19.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF74179.1 - 1.3e-25 90.0 42.4 3.3e-20 72.3 16.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily SH PF01445.17 EXF74179.1 - 0.17 11.9 1.1 0.5 10.4 0.1 2.3 2 0 0 2 2 2 0 Viral small hydrophobic protein Glyco_hydro_3_C PF01915.22 EXF74180.1 - 3e-59 200.4 0.0 6.8e-59 199.2 0.0 1.6 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 EXF74180.1 - 7.7e-43 147.1 0.0 1.6e-42 146.0 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 EXF74180.1 - 4.4e-15 55.6 0.2 9.8e-15 54.4 0.2 1.6 1 0 0 1 1 1 1 Fibronectin type III-like domain PA14 PF07691.12 EXF74180.1 - 1.2e-09 38.2 0.0 2e-09 37.4 0.0 1.3 1 0 0 1 1 1 1 PA14 domain Fungal_trans PF04082.18 EXF74181.1 - 4.5e-08 32.4 1.4 5e-07 29.0 1.4 2.3 1 1 0 1 1 1 1 Fungal specific transcription factor domain Glyco_hydro_28 PF00295.17 EXF74182.1 - 1.9e-102 342.7 24.3 2.4e-102 342.3 24.3 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 ADH_zinc_N PF00107.26 EXF74183.1 - 1.9e-31 108.7 0.1 3.1e-31 108.0 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EXF74183.1 - 1.4e-17 65.0 0.0 3.2e-17 63.8 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EXF74183.1 - 1e-10 41.5 0.0 2.5e-10 40.2 0.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain TrkA_N PF02254.18 EXF74183.1 - 0.0005 20.3 0.0 0.0009 19.5 0.0 1.4 1 0 0 1 1 1 1 TrkA-N domain ELFV_dehydrog PF00208.21 EXF74183.1 - 0.078 12.7 0.3 0.15 11.8 0.3 1.5 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase p450 PF00067.22 EXF74185.1 - 4.7e-48 164.1 0.0 1.4e-45 156.0 0.0 2.0 2 0 0 2 2 2 2 Cytochrome P450 Asp PF00026.23 EXF74186.1 - 5.2e-57 193.6 0.0 6.5e-57 193.3 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EXF74186.1 - 6.8e-15 55.7 1.2 9.1e-14 52.1 1.2 2.3 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal Serglycin PF04360.12 EXF74186.1 - 0.025 14.5 1.5 0.056 13.4 1.5 1.5 1 0 0 1 1 1 0 Serglycin Asp_protease_2 PF13650.6 EXF74186.1 - 0.063 13.9 0.1 14 6.4 0.0 3.2 2 1 0 2 2 2 0 Aspartyl protease gag-asp_proteas PF13975.6 EXF74186.1 - 0.09 13.3 0.0 3 8.5 0.0 2.9 2 1 0 2 2 2 0 gag-polyprotein putative aspartyl protease HET PF06985.11 EXF74187.1 - 2.1e-22 80.0 0.0 6.1e-22 78.5 0.0 1.8 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) NACHT PF05729.12 EXF74187.1 - 0.00022 21.2 0.0 0.00071 19.5 0.0 1.9 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 EXF74187.1 - 0.037 14.3 0.0 1 9.6 0.0 3.3 3 0 0 3 3 3 0 AAA domain NB-ARC PF00931.22 EXF74187.1 - 0.062 12.5 0.0 0.15 11.2 0.0 1.6 1 0 0 1 1 1 0 NB-ARC domain SNF2_N PF00176.23 EXF74188.1 - 1.2e-63 215.0 0.1 1.6e-63 214.5 0.1 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EXF74188.1 - 6e-15 55.5 0.0 1.6e-14 54.2 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EXF74188.1 - 9.9e-08 31.9 0.0 4.3e-07 29.9 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 EXF74188.1 - 8.4e-06 25.9 0.0 0.00012 22.1 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit zf-RING_5 PF14634.6 EXF74188.1 - 0.00018 21.4 6.2 0.00039 20.3 6.2 1.6 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EXF74188.1 - 0.0025 17.6 2.4 0.01 15.7 2.4 2.0 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 AAA_34 PF13872.6 EXF74188.1 - 0.019 13.9 0.2 0.044 12.7 0.2 1.5 1 0 0 1 1 1 0 P-loop containing NTP hydrolase pore-1 zf-RING_2 PF13639.6 EXF74188.1 - 0.022 15.1 6.3 0.074 13.4 6.3 2.0 1 0 0 1 1 1 0 Ring finger domain ERCC3_RAD25_C PF16203.5 EXF74188.1 - 0.11 11.7 0.0 0.19 10.9 0.0 1.3 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase zf-C3HC4 PF00097.25 EXF74188.1 - 0.17 11.7 6.6 0.43 10.5 6.6 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EXF74188.1 - 0.17 11.7 10.7 0.2 11.5 5.6 3.5 3 1 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EXF74188.1 - 0.29 11.2 6.3 0.7 10.0 6.3 1.7 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EXF74188.1 - 0.32 10.9 4.6 0.83 9.6 4.6 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) FYVE PF01363.21 EXF74188.1 - 0.49 10.6 3.3 1.2 9.3 3.3 1.6 1 0 0 1 1 1 0 FYVE zinc finger Fungal_trans PF04082.18 EXF74190.1 - 7.9e-20 71.0 0.2 1.2e-19 70.5 0.2 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 EXF74190.1 - 1.3e-08 34.8 13.4 0.00019 21.7 2.0 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EXF74190.1 - 1.3e-06 28.6 12.9 2.3e-06 27.8 7.1 2.8 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 EXF74190.1 - 0.00047 20.8 13.0 0.037 14.9 2.1 3.0 2 0 0 2 2 2 2 C2H2-type zinc finger C1_4 PF07975.12 EXF74190.1 - 0.37 11.0 2.1 0.9 9.8 2.1 1.6 1 0 0 1 1 1 0 TFIIH C1-like domain zf-C2H2_jaz PF12171.8 EXF74190.1 - 0.91 9.9 3.7 0.43 10.9 0.4 2.2 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EXF74190.1 - 2.7 8.5 5.2 0.63 10.5 1.1 2.1 2 0 0 2 2 2 0 Zinc-finger of C2H2 type RINGv PF12906.7 EXF74191.1 - 0.00013 22.0 7.0 0.00022 21.3 7.0 1.4 1 0 0 1 1 1 1 RING-variant domain FANCL_C PF11793.8 EXF74191.1 - 0.00027 21.0 3.0 0.00051 20.2 3.0 1.5 1 0 0 1 1 1 1 FANCL C-terminal domain zf-RING_2 PF13639.6 EXF74191.1 - 0.00099 19.4 5.9 0.0016 18.7 5.9 1.3 1 0 0 1 1 1 1 Ring finger domain Glyco_hydro_16 PF00722.21 EXF74192.1 - 3.4e-41 140.6 4.1 5.7e-41 139.9 4.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 DUF3112 PF11309.8 EXF74194.1 - 1.7e-08 34.2 15.7 2.7e-08 33.5 0.7 2.4 2 1 1 3 3 3 2 Protein of unknown function (DUF3112) Glyco_hydro_39 PF01229.17 EXF74195.1 - 0.033 12.8 0.3 0.066 11.8 0.2 1.5 1 1 1 2 2 2 0 Glycosyl hydrolases family 39 NAD_binding_8 PF13450.6 EXF74196.1 - 5.5e-09 36.1 0.6 1.2e-08 35.1 0.1 1.9 2 0 0 2 2 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EXF74196.1 - 7.4e-09 35.2 0.9 1.5e-08 34.1 0.9 1.5 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 EXF74196.1 - 3.8e-07 29.8 0.3 6e-07 29.2 0.3 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO PF01266.24 EXF74196.1 - 5.5e-06 26.2 0.7 1.3e-05 25.0 0.5 1.6 2 0 0 2 2 2 1 FAD dependent oxidoreductase HI0933_like PF03486.14 EXF74196.1 - 1.1e-05 24.4 0.3 1.6e-05 23.8 0.3 1.2 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_2 PF07992.14 EXF74196.1 - 0.00017 21.0 0.0 0.00032 20.0 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 EXF74196.1 - 0.0028 17.0 0.1 0.25 10.6 0.1 2.1 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase Thi4 PF01946.17 EXF74196.1 - 0.0038 16.5 0.1 0.0076 15.5 0.1 1.4 1 0 0 1 1 1 1 Thi4 family Pyr_redox PF00070.27 EXF74196.1 - 0.007 16.9 0.4 0.016 15.8 0.1 1.7 2 0 0 2 2 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EXF74196.1 - 0.0074 15.6 0.0 0.021 14.1 0.0 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EXF74196.1 - 0.0089 15.3 0.2 0.014 14.7 0.2 1.3 1 0 0 1 1 1 1 FAD binding domain GIDA PF01134.22 EXF74196.1 - 0.013 14.6 0.2 0.022 13.9 0.2 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A Trp_halogenase PF04820.14 EXF74196.1 - 0.1 11.4 0.4 0.17 10.7 0.4 1.3 1 0 0 1 1 1 0 Tryptophan halogenase Lycopene_cycl PF05834.12 EXF74196.1 - 0.11 11.5 0.0 0.17 10.9 0.0 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein Metallothio PF00131.20 EXF74198.1 - 0.0071 16.5 16.1 0.0071 16.5 16.1 1.0 1 0 0 1 1 1 1 Metallothionein PetM PF08041.11 EXF74199.1 - 0.034 13.7 0.6 0.087 12.4 0.6 1.7 1 0 0 1 1 1 0 PetM family of cytochrome b6f complex subunit 7 Asp PF00026.23 EXF74203.1 - 2.7e-40 138.7 1.1 6.7e-39 134.1 1.1 2.0 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_C PF14541.6 EXF74203.1 - 0.00052 19.8 0.1 0.016 14.9 0.1 2.4 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal Asp_protease_2 PF13650.6 EXF74203.1 - 0.11 13.1 0.3 26 5.6 0.0 3.4 3 0 0 3 3 3 0 Aspartyl protease DUF2235 PF09994.9 EXF74204.1 - 2e-53 181.7 0.0 3e-53 181.1 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) MMR_HSR1 PF01926.23 EXF74204.1 - 2.3e-05 24.4 0.1 5.3e-05 23.3 0.1 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EXF74204.1 - 0.00023 21.1 0.0 0.00058 19.8 0.0 1.6 1 0 0 1 1 1 1 RsgA GTPase Roc PF08477.13 EXF74204.1 - 0.0013 18.9 0.1 0.29 11.4 0.0 2.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase AAA_22 PF13401.6 EXF74204.1 - 0.0022 18.3 0.0 0.042 14.1 0.0 2.4 2 0 0 2 2 2 1 AAA domain Septin PF00735.18 EXF74204.1 - 0.014 14.7 0.0 0.023 14.0 0.0 1.3 1 0 0 1 1 1 0 Septin AAA_16 PF13191.6 EXF74204.1 - 0.039 14.3 0.0 0.11 12.8 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain DUF2200 PF09966.9 EXF74204.1 - 0.074 13.2 0.5 20 5.3 0.2 3.1 2 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2200) Prim-Pol PF09250.11 EXF74204.1 - 0.092 13.1 0.0 0.21 11.9 0.0 1.6 1 0 0 1 1 1 0 Bifunctional DNA primase/polymerase, N-terminal ABC_tran PF00005.27 EXF74204.1 - 0.14 12.7 0.0 0.32 11.5 0.0 1.6 1 0 0 1 1 1 0 ABC transporter AAA_29 PF13555.6 EXF74204.1 - 0.16 11.8 0.0 0.34 10.7 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain GalKase_gal_bdg PF10509.9 EXF74205.1 - 1.1e-19 69.7 0.0 2e-19 68.8 0.0 1.5 1 0 0 1 1 1 1 Galactokinase galactose-binding signature GHMP_kinases_N PF00288.26 EXF74205.1 - 4.8e-15 55.5 1.9 1.3e-14 54.1 1.9 1.8 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 EXF74205.1 - 4.4e-13 49.4 0.0 1.6e-12 47.6 0.0 2.0 1 0 0 1 1 1 1 GHMP kinases C terminal HTH_23 PF13384.6 EXF74205.1 - 0.022 14.6 0.0 0.057 13.2 0.0 1.7 1 0 0 1 1 1 0 Homeodomain-like domain HTH_3 PF01381.22 EXF74205.1 - 0.028 14.5 0.0 0.086 12.9 0.0 1.9 1 0 0 1 1 1 0 Helix-turn-helix Sigma70_r4_2 PF08281.12 EXF74205.1 - 0.076 12.7 0.1 0.19 11.4 0.1 1.6 1 0 0 1 1 1 0 Sigma-70, region 4 NmrA PF05368.13 EXF74206.1 - 5.5e-35 121.0 0.0 7.1e-35 120.6 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EXF74206.1 - 1.2e-10 41.6 0.1 1.9e-10 41.0 0.1 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EXF74206.1 - 4.5e-05 23.0 0.1 9.4e-05 22.0 0.0 1.6 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EXF74206.1 - 0.0021 17.1 0.0 0.0029 16.7 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family TrkA_N PF02254.18 EXF74206.1 - 0.022 15.0 0.0 0.039 14.2 0.0 1.4 1 0 0 1 1 1 0 TrkA-N domain adh_short_C2 PF13561.6 EXF74206.1 - 0.052 13.1 0.2 0.094 12.3 0.2 1.4 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF74206.1 - 0.087 12.3 0.2 0.2 11.1 0.2 1.6 1 0 0 1 1 1 0 short chain dehydrogenase Zn_clus PF00172.18 EXF74207.1 - 0.013 15.6 0.6 0.024 14.8 0.6 1.3 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain FAD_oxidored PF12831.7 EXF74208.1 - 1.3e-47 163.1 0.1 5.7e-32 111.6 0.0 2.2 1 1 1 2 2 2 2 FAD dependent oxidoreductase DAO PF01266.24 EXF74208.1 - 1.6e-06 28.0 0.2 3e-06 27.0 0.2 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EXF74208.1 - 4.7e-06 26.0 1.7 9.7e-06 24.9 1.7 1.5 1 0 0 1 1 1 1 FAD binding domain GIDA PF01134.22 EXF74208.1 - 6.1e-06 25.6 0.2 8.7e-06 25.1 0.2 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A NAD_binding_8 PF13450.6 EXF74208.1 - 9.8e-06 25.7 1.5 1.6e-05 25.1 0.2 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EXF74208.1 - 5.6e-05 22.5 0.0 9e-05 21.8 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EXF74208.1 - 6e-05 23.5 0.3 0.00012 22.5 0.3 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 EXF74208.1 - 0.0081 15.5 0.3 0.014 14.7 0.3 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain HI0933_like PF03486.14 EXF74208.1 - 0.026 13.2 0.2 0.038 12.7 0.2 1.2 1 0 0 1 1 1 0 HI0933-like protein Pyr_redox_3 PF13738.6 EXF74208.1 - 0.11 11.7 0.0 0.17 11.1 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Lactamase_B PF00753.27 EXF74209.1 - 7.1e-07 29.4 0.3 2.8e-06 27.5 0.2 2.0 2 1 0 2 2 2 1 Metallo-beta-lactamase superfamily p450 PF00067.22 EXF74210.1 - 4.7e-64 216.8 0.0 6.4e-64 216.4 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 adh_short_C2 PF13561.6 EXF74210.1 - 3.8e-45 154.3 2.0 8.1e-45 153.2 1.6 1.7 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF74210.1 - 3.1e-44 150.8 1.3 5.6e-44 149.9 1.3 1.4 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EXF74210.1 - 1e-09 38.6 0.3 2.2e-09 37.5 0.3 1.5 1 0 0 1 1 1 1 KR domain ADSL_C PF10397.9 EXF74210.1 - 0.11 13.1 0.3 2.1 8.9 0.0 3.1 3 0 0 3 3 3 0 Adenylosuccinate lyase C-terminus p450 PF00067.22 EXF74211.1 - 3.2e-64 217.4 0.0 1.7e-52 178.8 0.0 2.0 2 0 0 2 2 2 2 Cytochrome P450 PS_Dcarbxylase PF02666.15 EXF74212.1 - 1.9e-45 154.9 0.0 2.6e-45 154.5 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase NST1 PF13945.6 EXF74213.1 - 9.6e-52 175.9 20.2 9.6e-52 175.9 20.2 5.3 4 2 1 5 5 5 1 Salt tolerance down-regulator TFIIA PF03153.13 EXF74213.1 - 5.6e-06 26.6 19.0 5.6e-06 26.6 19.0 4.0 2 1 2 4 4 4 1 Transcription factor IIA, alpha/beta subunit Ras PF00071.22 EXF74214.1 - 1.4e-51 174.3 0.0 1.6e-51 174.1 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EXF74214.1 - 1.5e-22 80.0 0.0 2.1e-22 79.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EXF74214.1 - 2.9e-06 26.8 0.0 4.4e-06 26.3 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EXF74214.1 - 0.011 15.1 0.0 0.014 14.7 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EXF74214.1 - 0.012 15.2 0.0 0.046 13.3 0.0 1.7 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain SRPRB PF09439.10 EXF74214.1 - 0.047 13.1 0.0 0.062 12.7 0.0 1.3 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 EXF74214.1 - 0.077 13.1 0.0 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase PduV-EutP PF10662.9 EXF74214.1 - 0.18 11.5 0.0 4.7 6.9 0.0 2.4 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation MRP-L28 PF09812.9 EXF74215.1 - 0.0062 16.7 0.9 0.007 16.5 0.9 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L28 DUF3439 PF11921.8 EXF74215.1 - 0.042 13.8 3.2 0.062 13.3 3.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) AT_hook PF02178.19 EXF74216.1 - 2.2 8.4 7.9 7.4 6.8 7.9 2.0 1 0 0 1 1 1 0 AT hook motif DUF3632 PF12311.8 EXF74217.1 - 7.4e-32 111.2 2.6 1.1e-31 110.6 1.5 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF3632) Hph PF13694.6 EXF74219.1 - 0.13 12.6 2.4 0.2 12.0 2.4 1.3 1 0 0 1 1 1 0 Sec63/Sec62 complex-interacting family DAO_C PF16901.5 EXF74220.1 - 0.003 17.4 0.0 0.045 13.6 0.0 2.2 2 0 0 2 2 2 1 C-terminal domain of alpha-glycerophosphate oxidase DUF3383 PF11863.8 EXF74220.1 - 0.067 12.2 5.6 0.1 11.6 5.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3383) zf-C2H2 PF00096.26 EXF74220.1 - 4.6 7.9 11.9 0.59 10.7 1.6 3.3 3 0 0 3 3 3 0 Zinc finger, C2H2 type NIR_SIR_ferr PF03460.17 EXF74221.1 - 0.046 13.6 0.0 0.088 12.7 0.0 1.4 1 0 0 1 1 1 0 Nitrite/Sulfite reductase ferredoxin-like half domain DUF4957 PF16318.5 EXF74221.1 - 0.11 12.5 0.0 0.19 11.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4957) zf-C2H2 PF00096.26 EXF74221.1 - 9.1 7.0 9.8 18 6.0 0.3 3.8 4 0 0 4 4 4 0 Zinc finger, C2H2 type TPP_enzyme_N PF02776.18 EXF74222.1 - 1.4e-53 181.1 0.1 6.9e-51 172.3 0.0 2.5 2 0 0 2 2 2 2 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 EXF74222.1 - 2.5e-50 170.2 0.2 1.5e-49 167.7 0.2 2.2 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 EXF74222.1 - 1.8e-39 134.6 0.4 4.4e-39 133.3 0.4 1.7 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain DUF2500 PF10694.9 EXF74223.1 - 0.02 15.4 0.1 0.27 11.7 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2500) PHO4 PF01384.20 EXF74223.1 - 6.7 5.7 9.7 7.6 5.5 0.1 2.2 1 1 1 2 2 2 0 Phosphate transporter family Inhibitor_I78 PF11720.8 EXF74224.1 - 1.7e-10 40.8 0.0 2e-10 40.6 0.0 1.1 1 0 0 1 1 1 1 Peptidase inhibitor I78 family potato_inhibit PF00280.18 EXF74224.1 - 0.00022 21.9 0.1 0.00028 21.5 0.1 1.3 1 1 0 1 1 1 1 Potato inhibitor I family Pre-PUA PF17832.1 EXF74225.1 - 1.4e-21 77.0 2.1 1.9e-21 76.5 2.1 1.2 1 0 0 1 1 1 1 Pre-PUA-like domain PUA PF01472.20 EXF74225.1 - 4.3e-13 49.0 0.1 2.4e-12 46.6 0.1 2.0 1 1 0 1 1 1 1 PUA domain tRNA-synt_2 PF00152.20 EXF74226.1 - 1.1e-70 238.3 0.0 1.3e-70 238.0 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) Pkinase PF00069.25 EXF74228.1 - 3e-06 26.8 0.0 5.1e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Aldolase_II PF00596.21 EXF74229.1 - 7.9e-46 156.3 0.0 9.6e-46 156.1 0.0 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain Fungal_trans_2 PF11951.8 EXF74230.1 - 8.8e-49 166.3 0.3 1.1e-48 165.9 0.3 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain RPN5_C PF18098.1 EXF74230.1 - 0.68 10.1 2.3 1.1 9.4 0.2 2.5 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN5 C-terminal domain Pectate_lyase PF03211.13 EXF74232.1 - 1.3e-86 289.3 12.1 2e-86 288.7 12.1 1.2 1 0 0 1 1 1 1 Pectate lyase Fungal_trans PF04082.18 EXF74233.1 - 1.1e-13 50.8 0.0 1.8e-13 50.2 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Aminotran_3 PF00202.21 EXF74234.1 - 2.5e-98 329.4 0.1 3e-98 329.1 0.1 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 EXF74234.1 - 0.02 14.1 0.1 0.045 12.9 0.0 1.5 2 0 0 2 2 2 0 Aminotransferase class I and II MFS_1 PF07690.16 EXF74235.1 - 1.6e-24 86.5 60.5 2.4e-17 62.9 34.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Pec_lyase_C PF00544.19 EXF74236.1 - 9.2e-19 67.9 11.7 1.9e-17 63.6 11.5 2.7 1 1 0 1 1 1 1 Pectate lyase Beta_helix PF13229.6 EXF74236.1 - 2.8e-08 33.8 20.1 1e-05 25.4 9.7 2.2 1 1 0 2 2 2 2 Right handed beta helix region Acetyltransf_3 PF13302.7 EXF74237.1 - 5.7e-16 59.4 0.0 8.7e-16 58.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EXF74237.1 - 4.5e-08 33.3 0.0 7e-08 32.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_4 PF13420.7 EXF74237.1 - 0.0067 16.6 0.0 0.06 13.5 0.0 2.0 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain GFO_IDH_MocA PF01408.22 EXF74239.1 - 1e-11 45.7 0.1 1.9e-11 44.8 0.0 1.4 2 0 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold Pterin_bind PF00809.22 EXF74240.1 - 5e-76 255.6 0.0 6.6e-76 255.2 0.0 1.2 1 0 0 1 1 1 1 Pterin binding enzyme HPPK PF01288.20 EXF74240.1 - 1.8e-36 125.0 0.0 4.7e-36 123.7 0.0 1.7 2 0 0 2 2 2 1 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) NMO PF03060.15 EXF74241.1 - 8e-56 189.8 1.2 1e-55 189.4 1.2 1.2 1 0 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.25 EXF74241.1 - 5.2e-12 45.4 0.4 7.4e-12 44.9 0.4 1.3 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.18 EXF74241.1 - 3.7e-06 26.2 2.8 5.8e-06 25.6 2.8 1.2 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Glu_synthase PF01645.17 EXF74241.1 - 0.0031 16.7 2.2 0.0037 16.5 0.8 1.8 2 0 0 2 2 2 1 Conserved region in glutamate synthase DHO_dh PF01180.21 EXF74241.1 - 0.015 14.5 0.1 0.023 13.9 0.1 1.2 1 0 0 1 1 1 0 Dihydroorotate dehydrogenase NanE PF04131.14 EXF74241.1 - 0.068 12.3 0.1 0.16 11.1 0.1 1.6 1 0 0 1 1 1 0 Putative N-acetylmannosamine-6-phosphate epimerase ArfGap PF01412.18 EXF74242.1 - 6.9e-35 119.7 0.1 1.3e-34 118.7 0.1 1.5 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf TIM21 PF08294.11 EXF74243.1 - 6.6e-43 146.1 0.1 8.2e-43 145.8 0.1 1.1 1 0 0 1 1 1 1 TIM21 Coa1 PF08695.10 EXF74243.1 - 1.1e-05 25.1 0.0 2.2e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 Cytochrome oxidase complex assembly protein 1 Carla_C4 PF01623.17 EXF74243.1 - 0.12 12.3 0.0 0.23 11.5 0.0 1.4 1 0 0 1 1 1 0 Carlavirus putative nucleic acid binding protein SLATT_fungal PF18142.1 EXF74244.1 - 6.2e-28 97.2 0.0 1.3e-27 96.2 0.0 1.6 1 0 0 1 1 1 1 SMODS and SLOG-associating 2TM effector domain SLATT_1 PF18181.1 EXF74244.1 - 0.1 12.5 0.0 0.2 11.6 0.0 1.4 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain 1 ATPase PF06745.13 EXF74246.1 - 7.5e-07 28.7 0.0 1.2e-06 28.1 0.0 1.3 1 0 0 1 1 1 1 KaiC Rad51 PF08423.11 EXF74246.1 - 1.7e-06 27.5 0.1 0.002 17.4 0.0 2.2 2 0 0 2 2 2 2 Rad51 RecA PF00154.21 EXF74246.1 - 3.4e-06 26.7 0.6 4.5e-06 26.3 0.0 1.4 2 0 0 2 2 2 1 recA bacterial DNA recombination protein DnaB_C PF03796.15 EXF74246.1 - 6.1e-05 22.5 0.0 0.13 11.5 0.0 2.1 2 0 0 2 2 2 2 DnaB-like helicase C terminal domain AAA_25 PF13481.6 EXF74246.1 - 9.7e-05 22.0 0.8 0.00021 20.9 0.1 1.8 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 EXF74246.1 - 0.0066 16.3 0.0 0.0097 15.7 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EXF74246.1 - 0.031 14.7 0.0 0.079 13.3 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 EXF74246.1 - 0.11 12.8 0.0 0.19 12.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EXF74246.1 - 0.18 12.0 0.0 0.29 11.3 0.0 1.4 1 1 0 1 1 1 0 AAA domain PhoH PF02562.16 EXF74246.1 - 0.19 11.2 0.1 0.43 10.0 0.1 1.5 1 0 0 1 1 1 0 PhoH-like protein AAA PF00004.29 EXF74246.1 - 0.21 12.0 0.0 0.37 11.2 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.17 EXF74246.1 - 0.23 11.2 0.1 0.46 10.2 0.1 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein zf-H2C2_2 PF13465.6 EXF74247.1 - 1.6e-09 37.7 18.6 2e-05 24.8 3.5 4.1 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2 PF00096.26 EXF74247.1 - 2.9e-06 27.4 20.8 0.00045 20.5 4.5 2.9 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EXF74247.1 - 0.0014 19.3 16.1 0.051 14.4 3.1 3.1 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EXF74247.1 - 0.053 13.8 0.4 0.053 13.8 0.4 2.6 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding FOXP-CC PF16159.5 EXF74247.1 - 0.12 13.1 0.1 0.12 13.1 0.1 2.8 3 1 1 4 4 4 0 FOXP coiled-coil domain zf-C2H2_6 PF13912.6 EXF74247.1 - 0.26 11.3 5.8 2.3 8.3 0.3 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger DUF2225 PF09986.9 EXF74247.1 - 0.3 10.8 0.8 0.61 9.8 0.8 1.5 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2225) zf-H2C2_5 PF13909.6 EXF74247.1 - 3 7.7 12.9 3.1 7.6 0.1 3.6 3 0 0 3 3 3 0 C2H2-type zinc-finger domain adh_short_C2 PF13561.6 EXF74248.1 - 3.2e-51 174.1 0.3 3.9e-51 173.9 0.3 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF74248.1 - 4e-51 173.3 0.5 4.7e-51 173.0 0.5 1.0 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EXF74248.1 - 2.2e-14 53.8 1.8 5e-14 52.6 1.8 1.6 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 EXF74248.1 - 7.3e-06 25.6 0.2 1.2e-05 24.9 0.2 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Glyco_transf_5 PF08323.11 EXF74248.1 - 0.0012 18.6 0.0 0.046 13.4 0.0 2.4 2 1 1 3 3 3 1 Starch synthase catalytic domain GDP_Man_Dehyd PF16363.5 EXF74248.1 - 0.004 16.6 0.1 0.006 16.0 0.1 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Glyco_transf_4 PF13439.6 EXF74248.1 - 0.027 14.5 0.0 2.9 7.9 0.0 2.2 2 0 0 2 2 2 0 Glycosyltransferase Family 4 ApbA PF02558.16 EXF74248.1 - 0.099 12.3 0.1 0.15 11.7 0.1 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA THF_DHG_CYH_C PF02882.19 EXF74248.1 - 0.099 12.0 0.0 0.21 10.9 0.0 1.5 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain MR_MLE_C PF13378.6 EXF74249.1 - 9.3e-55 185.6 0.0 1.2e-54 185.2 0.0 1.1 1 0 0 1 1 1 1 Enolase C-terminal domain-like MR_MLE_N PF02746.16 EXF74249.1 - 1.1e-19 70.7 0.0 2.2e-19 69.8 0.0 1.4 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain MFS_1 PF07690.16 EXF74250.1 - 1.4e-51 175.5 39.3 5.1e-50 170.4 39.9 2.5 1 1 1 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EXF74250.1 - 3.5e-11 42.2 16.1 3.5e-11 42.2 16.1 1.3 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EXF74250.1 - 4.4e-10 39.0 9.7 4.4e-10 39.0 9.7 2.3 2 1 0 2 2 2 1 Sugar (and other) transporter OATP PF03137.20 EXF74250.1 - 0.015 13.6 14.6 0.013 13.8 2.8 3.0 2 1 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family Sec61_beta PF03911.16 EXF74250.1 - 0.17 11.9 0.2 0.17 11.9 0.2 2.8 2 0 0 2 2 2 0 Sec61beta family Transp_cyt_pur PF02133.15 EXF74251.1 - 8.2e-80 268.7 38.6 1e-79 268.4 38.6 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin DUF4235 PF14019.6 EXF74251.1 - 0.024 14.7 4.5 0.076 13.1 0.0 3.5 4 0 0 4 4 4 0 Protein of unknown function (DUF4235) Fungal_trans PF04082.18 EXF74252.1 - 8.4e-24 84.0 0.3 1.3e-23 83.4 0.3 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Polysacc_deac_1 PF01522.21 EXF74252.1 - 3e-09 36.8 0.0 7.6e-09 35.5 0.0 1.6 1 0 0 1 1 1 1 Polysaccharide deacetylase Zn_clus PF00172.18 EXF74252.1 - 4.7e-05 23.4 3.2 0.0001 22.3 3.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Amidase PF01425.21 EXF74253.1 - 2.7e-89 300.2 0.0 3.7e-89 299.7 0.0 1.1 1 0 0 1 1 1 1 Amidase MFS_1 PF07690.16 EXF74254.1 - 3.4e-43 147.9 56.4 2e-42 145.4 37.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF74254.1 - 2e-11 43.5 9.4 2e-11 43.5 9.4 3.1 3 1 0 3 3 3 1 Sugar (and other) transporter FAD_binding_3 PF01494.19 EXF74256.1 - 8.3e-06 25.3 2.1 0.07 12.4 0.3 3.4 4 0 0 4 4 4 2 FAD binding domain DAO PF01266.24 EXF74256.1 - 0.00043 20.0 0.1 0.0015 18.2 0.1 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EXF74256.1 - 0.002 18.3 0.0 0.0052 17.0 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DUF1013 PF06242.11 EXF74256.1 - 0.0049 16.9 0.4 0.01 15.9 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF1013) NAD_binding_9 PF13454.6 EXF74256.1 - 0.0056 16.7 0.0 0.017 15.2 0.0 1.8 1 0 0 1 1 1 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 EXF74256.1 - 0.0088 15.3 0.0 0.015 14.6 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EXF74256.1 - 0.038 13.3 0.0 0.072 12.3 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EXF74256.1 - 0.083 12.1 0.1 0.23 10.7 0.0 1.7 2 0 0 2 2 2 0 Thi4 family HI0933_like PF03486.14 EXF74256.1 - 0.18 10.5 0.1 0.32 9.7 0.1 1.4 1 0 0 1 1 1 0 HI0933-like protein Transferase PF02458.15 EXF74257.1 - 5.2e-40 137.4 0.0 1.2e-17 63.7 0.0 3.1 3 0 0 3 3 3 3 Transferase family DUF1195 PF06708.11 EXF74257.1 - 0.031 14.1 0.0 0.068 12.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1195) Tyrosinase PF00264.20 EXF74258.1 - 5.4e-54 183.8 0.0 8e-54 183.3 0.0 1.3 1 0 0 1 1 1 1 Common central domain of tyrosinase AA_permease_2 PF13520.6 EXF74260.1 - 1.1e-71 242.0 43.2 1.4e-71 241.6 43.2 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EXF74260.1 - 1e-13 50.7 42.5 3e-13 49.2 42.5 1.6 1 1 0 1 1 1 1 Amino acid permease Zn_clus PF00172.18 EXF74261.1 - 0.11 12.7 14.5 0.2 11.8 14.5 1.5 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Ribosomal_60s PF00428.19 EXF74261.1 - 0.24 12.0 3.3 7.4 7.2 0.2 2.5 2 0 0 2 2 2 0 60s Acidic ribosomal protein Fungal_trans PF04082.18 EXF74262.1 - 5.2e-11 42.1 0.0 7.9e-11 41.5 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF74262.1 - 8.3e-06 25.8 7.2 1.6e-05 24.9 7.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Ada_Zn_binding PF02805.16 EXF74263.1 - 0.007 16.4 0.0 0.015 15.3 0.0 1.6 1 0 0 1 1 1 1 Metal binding domain of Ada SMI1_KNR4 PF09346.10 EXF74264.1 - 0.14 12.6 0.0 0.32 11.4 0.0 1.7 1 1 0 1 1 1 0 SMI1 / KNR4 family (SUKH-1) PLAC8 PF04749.17 EXF74265.1 - 9.4e-23 81.1 12.0 1.2e-22 80.8 12.0 1.1 1 0 0 1 1 1 1 PLAC8 family p450 PF00067.22 EXF74266.1 - 1.3e-43 149.4 0.0 9.9e-42 143.2 0.0 2.1 1 1 1 2 2 2 2 Cytochrome P450 Epimerase PF01370.21 EXF74267.1 - 3.1e-21 75.9 0.0 4.3e-21 75.5 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EXF74267.1 - 4.7e-14 52.1 0.0 6.8e-14 51.5 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 EXF74267.1 - 3.4e-11 42.8 0.0 8.6e-11 41.5 0.0 1.6 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.6 EXF74267.1 - 1.1e-10 41.7 0.1 1.6e-10 41.2 0.1 1.3 1 0 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 EXF74267.1 - 4.8e-09 36.1 0.0 6.7e-09 35.6 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 EXF74267.1 - 2.3e-07 30.3 0.0 3.9e-07 29.5 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein KR PF08659.10 EXF74267.1 - 2.5e-06 27.5 0.1 4e-06 26.9 0.1 1.3 1 0 0 1 1 1 1 KR domain adh_short PF00106.25 EXF74267.1 - 0.00012 21.6 0.0 0.00054 19.5 0.0 1.9 2 0 0 2 2 2 1 short chain dehydrogenase F420_oxidored PF03807.17 EXF74267.1 - 0.0028 18.2 0.0 0.012 16.2 0.0 2.1 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent RmlD_sub_bind PF04321.17 EXF74267.1 - 0.0098 15.0 0.1 0.029 13.5 0.1 1.9 2 1 0 2 2 2 1 RmlD substrate binding domain NmrA PF05368.13 EXF74267.1 - 0.013 15.0 0.3 0.034 13.7 0.2 1.9 2 1 0 2 2 2 0 NmrA-like family adh_short_C2 PF13561.6 EXF74267.1 - 0.033 13.7 0.3 0.068 12.7 0.3 1.5 1 1 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase Glyco_trans_4_4 PF13579.6 EXF74267.1 - 0.072 13.5 0.8 0.17 12.3 0.8 1.8 1 1 0 1 1 1 0 Glycosyl transferase 4-like domain DUF3853 PF12964.7 EXF74268.1 - 0.044 13.9 0.1 0.053 13.7 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3853) Spt20 PF12090.8 EXF74268.1 - 0.11 12.0 6.3 0.11 12.0 6.3 1.1 1 0 0 1 1 1 0 Spt20 family TMEM247 PF15444.6 EXF74268.1 - 1.2 9.2 5.5 1.6 8.8 5.5 1.2 1 0 0 1 1 1 0 Transmembrane protein 247 HeLo PF14479.6 EXF74269.1 - 6.9e-33 114.2 0.1 2e-30 106.1 0.0 2.7 2 1 0 2 2 2 1 Prion-inhibition and propagation Pkinase_Tyr PF07714.17 EXF74269.1 - 0.12 11.6 0.0 1.1 8.4 0.0 2.0 2 0 0 2 2 2 0 Protein tyrosine kinase RRM_1 PF00076.22 EXF74270.1 - 2.3e-18 65.8 0.3 3.8e-18 65.1 0.1 1.5 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EXF74270.1 - 0.00032 20.3 0.0 0.00039 20.0 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EXF74270.1 - 0.03 14.2 0.0 0.048 13.5 0.0 1.3 1 0 0 1 1 1 0 Occluded RNA-recognition motif DPCD PF14913.6 EXF74270.1 - 0.052 12.9 0.1 0.071 12.5 0.1 1.2 1 0 0 1 1 1 0 DPCD protein family DUF4523 PF15023.6 EXF74270.1 - 0.14 11.9 0.0 0.25 11.2 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF4523) HhH-GPD PF00730.25 EXF74271.1 - 0.053 14.0 0.0 0.11 13.0 0.0 1.5 1 0 0 1 1 1 0 HhH-GPD superfamily base excision DNA repair protein Peptidase_C15 PF01470.17 EXF74272.1 - 1.6e-13 51.3 0.0 1e-06 29.1 0.0 2.9 2 1 0 2 2 2 2 Pyroglutamyl peptidase Hamartin PF04388.12 EXF74273.1 - 2.4 6.7 11.1 2.7 6.6 11.1 1.1 1 0 0 1 1 1 0 Hamartin protein VRR_NUC PF08774.11 EXF74274.1 - 1.4e-22 79.8 0.0 4e-22 78.3 0.0 1.8 1 0 0 1 1 1 1 VRR-NUC domain Dpy-30 PF05186.13 EXF74275.1 - 2.6e-11 43.0 0.0 3.6e-11 42.6 0.0 1.2 1 0 0 1 1 1 1 Dpy-30 motif Ribosomal_S13_N PF08069.12 EXF74276.1 - 1.2e-30 105.3 0.1 2.1e-30 104.5 0.1 1.4 1 0 0 1 1 1 1 Ribosomal S13/S15 N-terminal domain Ribosomal_S15 PF00312.22 EXF74276.1 - 3.2e-15 56.1 0.1 5e-15 55.5 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein S15 PAX PF00292.18 EXF74276.1 - 0.027 14.4 0.2 0.066 13.1 0.1 1.7 2 0 0 2 2 2 0 'Paired box' domain HOIP-UBA PF16678.5 EXF74276.1 - 0.073 13.1 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 HOIP UBA domain pair RRM_1 PF00076.22 EXF74277.1 - 5.1e-32 109.5 2.2 5.2e-13 48.6 0.0 4.1 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EXF74277.1 - 1.6e-05 24.7 0.0 0.094 12.6 0.0 3.2 3 0 0 3 3 3 2 Occluded RNA-recognition motif RRM_Rrp7 PF17799.1 EXF74277.1 - 0.016 15.0 0.1 0.05 13.4 0.2 1.7 2 0 0 2 2 2 0 Rrp7 RRM-like N-terminal domain TcpA PF05946.12 EXF74277.1 - 0.018 15.1 0.8 1.2 9.2 0.0 2.5 2 1 0 2 2 2 0 Toxin-coregulated pilus subunit TcpA Glycophorin_A PF01102.18 EXF74278.1 - 0.0085 16.3 2.0 0.078 13.2 0.0 2.9 3 0 0 3 3 3 1 Glycophorin A Fungal_trans PF04082.18 EXF74279.1 - 8e-07 28.4 0.2 6.1e-06 25.5 0.2 2.0 1 1 0 1 1 1 1 Fungal specific transcription factor domain Glyco_hydro_3_C PF01915.22 EXF74280.1 - 2.6e-63 213.7 0.0 4.9e-63 212.8 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 EXF74280.1 - 3.5e-47 161.3 0.0 5.7e-47 160.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 EXF74280.1 - 1.7e-21 76.1 0.3 8.1e-21 73.9 0.1 2.3 3 0 0 3 3 3 1 Fibronectin type III-like domain PA14 PF07691.12 EXF74280.1 - 7.2e-09 35.6 0.0 1.5e-08 34.6 0.0 1.5 1 0 0 1 1 1 1 PA14 domain DUF11 PF01345.18 EXF74280.1 - 0.048 14.0 4.3 0.056 13.8 2.1 2.2 2 0 0 2 2 2 0 Domain of unknown function DUF11 DUF4232 PF14016.6 EXF74280.1 - 0.063 13.4 1.7 0.14 12.3 0.9 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4232) Sugar_tr PF00083.24 EXF74281.1 - 9.6e-25 87.3 21.8 1.2e-24 87.0 21.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter HET PF06985.11 EXF74282.1 - 2.6e-11 44.0 5.0 3.8e-09 37.0 0.4 2.7 2 1 1 3 3 3 2 Heterokaryon incompatibility protein (HET) Abhydrolase_6 PF12697.7 EXF74283.1 - 1.1e-12 49.1 2.1 1.3e-12 48.8 2.1 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EXF74283.1 - 0.0068 15.7 0.0 0.01 15.1 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Ser_hydrolase PF06821.13 EXF74283.1 - 0.075 12.9 0.2 0.57 10.0 0.0 2.1 2 1 0 2 2 2 0 Serine hydrolase Methyltransf_23 PF13489.6 EXF74284.1 - 1.1e-20 74.1 0.0 1.9e-20 73.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF74284.1 - 2.5e-14 53.7 0.0 5.6e-14 52.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF74284.1 - 8.4e-14 52.1 0.0 2.7e-13 50.4 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF74284.1 - 1.6e-08 34.5 0.0 3.6e-07 30.1 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF74284.1 - 4.6e-08 33.7 0.0 2e-07 31.7 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EXF74284.1 - 4.1e-06 26.3 0.0 2.1e-05 24.0 0.0 1.9 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 EXF74284.1 - 0.0065 16.0 0.0 0.024 14.2 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_8 PF05148.15 EXF74284.1 - 0.011 15.6 0.0 0.019 14.8 0.0 1.4 1 0 0 1 1 1 0 Hypothetical methyltransferase Methyltransf_4 PF02390.17 EXF74284.1 - 0.017 14.6 0.0 0.081 12.4 0.0 1.9 2 0 0 2 2 2 0 Putative methyltransferase FtsJ PF01728.19 EXF74284.1 - 0.038 14.1 0.0 0.078 13.1 0.0 1.5 1 0 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_2 PF00891.18 EXF74284.1 - 0.071 12.4 0.0 0.18 11.1 0.0 1.6 1 0 0 1 1 1 0 O-methyltransferase domain PrmA PF06325.13 EXF74284.1 - 0.082 12.3 0.0 0.2 11.0 0.0 1.7 1 1 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) CMAS PF02353.20 EXF74284.1 - 0.22 10.8 0.0 0.35 10.1 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Peptidase_S8 PF00082.22 EXF74286.1 - 1e-42 146.4 0.0 4.6e-42 144.3 0.0 2.0 1 1 0 1 1 1 1 Subtilase family fn3_6 PF17766.1 EXF74286.1 - 6e-22 77.7 0.0 1.1e-21 76.8 0.0 1.5 1 0 0 1 1 1 1 Fibronectin type-III domain Inhibitor_I9 PF05922.16 EXF74286.1 - 2.2e-11 44.3 0.0 3.9e-11 43.5 0.0 1.4 1 0 0 1 1 1 1 Peptidase inhibitor I9 PA PF02225.22 EXF74286.1 - 1.1e-09 38.2 0.8 2.9e-09 36.8 0.8 1.7 1 0 0 1 1 1 1 PA domain Cu-oxidase_3 PF07732.15 EXF74287.1 - 6.1e-46 155.3 6.2 4.9e-45 152.4 0.8 3.3 3 0 0 3 3 3 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 EXF74287.1 - 1.5e-34 118.7 11.9 2.3e-30 105.1 0.5 4.2 4 0 0 4 4 4 3 Multicopper oxidase Cu-oxidase PF00394.22 EXF74287.1 - 5.5e-30 104.6 0.3 1.7e-28 99.7 0.0 2.9 3 1 0 3 3 3 1 Multicopper oxidase Cupredoxin_1 PF13473.6 EXF74287.1 - 0.0056 16.8 0.0 18 5.5 0.0 4.0 3 1 0 3 3 3 1 Cupredoxin-like domain DUF2615 PF11027.8 EXF74287.1 - 0.036 14.2 0.0 0.1 12.7 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2615) CAP_N PF01213.19 EXF74287.1 - 5.8 6.3 7.9 16 4.9 7.9 1.6 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Beta-lactamase PF00144.24 EXF74288.1 - 1.4e-63 215.1 0.0 1.7e-63 214.8 0.0 1.0 1 0 0 1 1 1 1 Beta-lactamase Tyrosinase PF00264.20 EXF74289.1 - 5.3e-53 180.6 0.0 7.2e-53 180.1 0.0 1.2 1 0 0 1 1 1 1 Common central domain of tyrosinase FAD_binding_3 PF01494.19 EXF74290.1 - 1.5e-24 86.9 0.0 1.9e-24 86.6 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EXF74290.1 - 3.8e-07 29.7 0.2 0.011 15.0 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EXF74290.1 - 7.4e-07 29.1 0.0 0.0014 18.3 0.0 2.1 2 0 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EXF74290.1 - 0.00026 21.2 0.0 0.0022 18.2 0.0 2.5 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain CoA_transf_3 PF02515.17 EXF74290.1 - 0.0017 17.5 0.0 0.0031 16.7 0.0 1.4 1 0 0 1 1 1 1 CoA-transferase family III Pyr_redox PF00070.27 EXF74290.1 - 0.0046 17.5 0.3 0.75 10.4 0.1 2.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EXF74290.1 - 0.0069 15.5 0.1 0.022 13.9 0.1 1.7 2 0 0 2 2 2 1 FAD binding domain Trp_halogenase PF04820.14 EXF74290.1 - 0.011 14.6 0.4 2 7.2 0.1 2.4 1 1 0 2 2 2 0 Tryptophan halogenase HI0933_like PF03486.14 EXF74290.1 - 0.094 11.4 0.1 6.3 5.4 0.0 2.8 2 1 0 3 3 3 0 HI0933-like protein GIDA PF01134.22 EXF74290.1 - 0.13 11.3 0.4 0.23 10.5 0.4 1.5 1 1 0 1 1 1 0 Glucose inhibited division protein A Acetyltransf_3 PF13302.7 EXF74291.1 - 1e-15 58.6 0.0 1.9e-15 57.7 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EXF74291.1 - 0.00037 20.7 0.5 0.0007 19.8 0.5 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Egh16-like PF11327.8 EXF74292.1 - 3.4e-27 96.1 9.2 3.4e-27 96.1 9.2 3.1 2 2 0 2 2 2 1 Egh16-like virulence factor Izumo-Ig PF16706.5 EXF74292.1 - 0.044 13.9 0.0 0.085 12.9 0.0 1.4 1 0 0 1 1 1 0 Izumo-like Immunoglobulin domain V-set PF07686.17 EXF74292.1 - 0.051 13.8 0.1 0.17 12.1 0.1 1.9 1 0 0 1 1 1 0 Immunoglobulin V-set domain EIF_2_alpha PF07541.12 EXF74292.1 - 0.092 12.9 0.0 0.2 11.7 0.0 1.5 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 2 alpha subunit DMP1 PF07263.11 EXF74292.1 - 0.94 8.3 10.6 1.3 7.8 10.6 1.1 1 0 0 1 1 1 0 Dentin matrix protein 1 (DMP1) HET PF06985.11 EXF74293.1 - 2.6e-15 57.1 1.7 5.2e-15 56.1 1.7 1.6 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) APH PF01636.23 EXF74294.1 - 3e-42 145.2 0.0 7e-42 144.0 0.0 1.5 1 1 1 2 2 2 1 Phosphotransferase enzyme family EcKinase PF02958.20 EXF74294.1 - 4.4e-06 26.2 0.0 6.4e-06 25.7 0.0 1.2 1 0 0 1 1 1 1 Ecdysteroid kinase Fructosamin_kin PF03881.14 EXF74294.1 - 0.00034 19.9 0.0 0.00098 18.4 0.0 1.7 1 1 0 1 1 1 1 Fructosamine kinase Kdo PF06293.14 EXF74294.1 - 0.00058 19.3 0.0 0.0016 17.8 0.0 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 EXF74294.1 - 0.0024 17.5 0.0 0.0036 16.9 0.0 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase RIO1 PF01163.22 EXF74294.1 - 0.0063 16.1 0.0 0.07 12.7 0.0 2.0 2 0 0 2 2 2 1 RIO1 family DUF1679 PF07914.11 EXF74294.1 - 0.026 13.4 0.0 0.11 11.3 0.0 1.8 2 1 0 2 2 2 0 Protein of unknown function (DUF1679) CBFB_NFYA PF02045.15 EXF74295.1 - 9.6e-29 99.8 4.6 2.3e-28 98.6 4.6 1.7 1 0 0 1 1 1 1 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B Hus1 PF04005.12 EXF74295.1 - 0.055 12.6 0.1 0.1 11.7 0.1 1.3 1 0 0 1 1 1 0 Hus1-like protein TFIIA PF03153.13 EXF74295.1 - 0.13 12.2 19.3 0.16 11.9 19.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit NAD_binding_8 PF13450.6 EXF74296.1 - 1.2e-09 38.3 0.1 2.6e-09 37.2 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 EXF74296.1 - 5.4e-08 32.6 0.6 1e-07 31.7 0.1 1.7 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EXF74296.1 - 3e-07 29.9 3.8 4.9e-07 29.2 3.8 1.3 1 0 0 1 1 1 1 FAD binding domain Amino_oxidase PF01593.24 EXF74296.1 - 7.4e-07 28.8 0.0 0.00089 18.7 0.0 2.2 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase Pyr_redox_2 PF07992.14 EXF74296.1 - 8.6e-07 28.5 1.0 1.1e-06 28.1 0.2 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EXF74296.1 - 2.1e-06 27.3 0.3 3.6e-06 26.5 0.3 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EXF74296.1 - 5.4e-06 25.4 3.3 8.1e-06 24.8 3.3 1.2 1 0 0 1 1 1 1 HI0933-like protein DAO PF01266.24 EXF74296.1 - 5.8e-06 26.1 1.6 1.2e-05 25.0 0.7 1.9 2 0 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.17 EXF74296.1 - 1.7e-05 24.2 0.1 2.8e-05 23.5 0.1 1.3 1 0 0 1 1 1 1 Thi4 family FAD_binding_3 PF01494.19 EXF74296.1 - 4.1e-05 23.0 0.0 6e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain GIDA PF01134.22 EXF74296.1 - 5e-05 22.6 0.7 7.1e-05 22.0 0.7 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A Pyr_redox PF00070.27 EXF74296.1 - 0.00015 22.2 1.5 0.00059 20.3 0.5 2.3 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 EXF74296.1 - 0.012 14.9 0.2 0.012 14.9 0.2 1.6 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_7 PF13241.6 EXF74296.1 - 0.016 15.7 0.0 0.032 14.7 0.0 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding Trp_halogenase PF04820.14 EXF74296.1 - 0.039 12.8 1.5 0.06 12.2 1.5 1.2 1 0 0 1 1 1 0 Tryptophan halogenase IlvN PF07991.12 EXF74296.1 - 0.058 13.0 1.5 0.079 12.5 0.4 1.8 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain Lycopene_cycl PF05834.12 EXF74296.1 - 0.058 12.4 0.1 0.087 11.9 0.1 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein UNC-93 PF05978.16 EXF74297.1 - 0.013 15.3 4.6 0.013 15.3 4.6 2.0 2 0 0 2 2 2 0 Ion channel regulatory protein UNC-93 DUF4307 PF14155.6 EXF74297.1 - 0.016 15.1 0.6 0.43 10.4 0.0 3.2 1 1 2 3 3 3 0 Domain of unknown function (DUF4307) Tyrosinase PF00264.20 EXF74298.1 - 2e-52 178.7 0.7 2.8e-52 178.2 0.7 1.2 1 0 0 1 1 1 1 Common central domain of tyrosinase SARA PF11409.8 EXF74298.1 - 6.3 7.1 6.7 15 5.9 6.7 1.6 1 0 0 1 1 1 0 Smad anchor for receptor activation (SARA) adh_short PF00106.25 EXF74300.1 - 1.2e-34 119.5 0.0 2.4e-34 118.5 0.0 1.5 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF74300.1 - 1.9e-23 83.3 0.1 2.8e-23 82.7 0.1 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF74300.1 - 4.8e-09 36.4 0.1 6.4e-09 36.0 0.1 1.2 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 EXF74300.1 - 0.096 12.0 0.0 0.16 11.3 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) SET PF00856.28 EXF74301.1 - 2.4e-13 50.8 0.1 8.1e-13 49.1 0.1 1.8 1 1 0 1 1 1 1 SET domain Metallophos PF00149.28 EXF74302.1 - 2.7e-08 34.6 0.1 3.9e-08 34.0 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EXF74302.1 - 8.1e-06 26.1 0.0 0.00018 21.7 0.0 2.1 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain DUF1907 PF08925.11 EXF74304.1 - 1.5e-108 362.6 0.0 1.7e-108 362.4 0.0 1.0 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1907) F-box-like PF12937.7 EXF74305.1 - 0.00027 20.8 0.6 0.0011 18.9 0.6 2.1 1 0 0 1 1 1 1 F-box-like Mad3_BUB1_I PF08311.12 EXF74306.1 - 1.2e-43 148.0 0.1 8.5e-43 145.3 0.3 2.2 2 0 0 2 2 2 1 Mad3/BUB1 homology region 1 Mad3_BUB1_II PF08171.11 EXF74306.1 - 3.9e-08 33.3 0.0 2.4e-07 30.8 0.0 2.3 2 1 0 2 2 2 1 Mad3/BUB1 homology region 2 Pkinase PF00069.25 EXF74306.1 - 2.2e-07 30.5 0.0 1.4e-06 27.9 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF74306.1 - 0.024 13.9 0.0 0.11 11.7 0.0 1.9 1 1 0 1 1 1 0 Protein tyrosine kinase Mad3_BUB1_I_2 PF17014.5 EXF74306.1 - 0.05 13.7 0.0 0.11 12.6 0.0 1.4 1 0 0 1 1 1 0 Putative Mad3/BUB1 like region 1 protein Kinase-like PF14531.6 EXF74306.1 - 0.19 11.0 0.0 0.36 10.1 0.0 1.4 1 0 0 1 1 1 0 Kinase-like PI3K_1B_p101 PF10486.9 EXF74306.1 - 9 3.9 7.5 13 3.4 7.5 1.2 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit AP_endonuc_2 PF01261.24 EXF74307.1 - 1.1e-34 119.8 0.2 1.5e-34 119.3 0.2 1.2 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel DUF2124 PF09897.9 EXF74307.1 - 0.014 15.3 0.0 0.033 14.1 0.0 1.7 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2124) DAGAT PF03982.13 EXF74308.1 - 1e-93 313.5 0.0 1.4e-93 313.1 0.0 1.1 1 0 0 1 1 1 1 Diacylglycerol acyltransferase FANCA_interact PF15751.5 EXF74308.1 - 0.18 12.3 3.5 0.12 12.9 0.7 2.0 1 1 1 2 2 2 0 FAAP20 FANCA interaction domain DUF4110 PF13422.6 EXF74309.1 - 6.2e-30 103.1 1.5 6.2e-30 103.1 1.5 3.0 3 0 0 3 3 2 1 Domain of unknown function (DUF4110) WLM PF08325.10 EXF74309.1 - 4e-25 89.0 0.1 4e-25 89.0 0.1 2.3 2 0 0 2 2 2 1 WLM domain Kelch_3 PF13415.6 EXF74309.1 - 2.3e-21 75.5 4.3 5.2e-07 29.8 0.0 5.7 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_4 PF13418.6 EXF74309.1 - 1e-19 70.3 11.8 7.8e-06 25.8 0.0 6.3 6 1 0 6 6 6 4 Galactose oxidase, central domain Kelch_5 PF13854.6 EXF74309.1 - 4.6e-17 61.6 2.0 2.7e-07 30.4 0.0 5.3 6 0 0 6 6 6 3 Kelch motif Kelch_2 PF07646.15 EXF74309.1 - 5.3e-14 51.6 0.6 0.0037 17.2 0.0 6.0 6 0 0 6 6 5 3 Kelch motif Kelch_6 PF13964.6 EXF74309.1 - 1.7e-11 43.9 1.3 0.00022 21.4 0.1 4.6 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.25 EXF74309.1 - 1.6e-09 37.2 0.5 0.0011 18.6 0.0 4.7 4 1 0 4 4 4 1 Kelch motif DUF45 PF01863.17 EXF74309.1 - 6.5e-07 29.6 0.5 6.5e-07 29.6 0.5 2.4 2 0 0 2 2 2 1 Protein of unknown function DUF45 Zn_ribbon_17 PF17120.5 EXF74309.1 - 0.29 10.8 2.8 0.71 9.5 2.8 1.6 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type Zf_RING PF16744.5 EXF74309.1 - 0.48 10.6 1.9 1.9 8.7 1.6 2.2 2 0 0 2 2 2 0 KIAA1045 RING finger Trimer_CC PF08954.11 EXF74312.1 - 0.025 14.1 1.1 0.12 11.9 0.2 2.1 2 0 0 2 2 2 0 Trimerisation motif CENP-Q PF13094.6 EXF74312.1 - 0.029 14.6 0.3 0.038 14.2 0.3 1.1 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit DUF1664 PF07889.12 EXF74312.1 - 0.07 13.2 0.0 0.092 12.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Thioredoxin PF00085.20 EXF74313.1 - 3.2e-63 210.2 8.6 2.5e-31 107.7 0.1 4.0 4 0 0 4 4 4 3 Thioredoxin Thioredoxin_6 PF13848.6 EXF74313.1 - 2.3e-48 164.5 1.5 2e-36 125.6 0.2 3.7 2 2 1 3 3 3 2 Thioredoxin-like domain Thioredoxin_8 PF13905.6 EXF74313.1 - 8.3e-11 42.1 0.1 0.0014 18.9 0.0 4.3 3 2 1 4 4 4 2 Thioredoxin-like Thioredoxin_7 PF13899.6 EXF74313.1 - 2.4e-09 37.2 0.1 0.0017 18.5 0.0 3.1 3 0 0 3 3 2 2 Thioredoxin-like Thioredoxin_2 PF13098.6 EXF74313.1 - 4.4e-09 36.7 1.0 0.0011 19.4 0.0 3.3 2 1 0 2 2 2 2 Thioredoxin-like domain OST3_OST6 PF04756.13 EXF74313.1 - 1.2e-08 34.7 2.4 0.0094 15.3 0.0 3.2 2 1 1 3 3 3 2 OST3 / OST6 family, transporter family Calsequestrin PF01216.17 EXF74313.1 - 3.2e-08 33.0 0.8 3.2e-08 33.0 0.8 2.5 1 1 2 3 3 3 1 Calsequestrin AhpC-TSA PF00578.21 EXF74313.1 - 4.5e-08 33.0 1.2 0.0061 16.5 0.1 3.0 3 0 0 3 3 3 2 AhpC/TSA family Redoxin PF08534.10 EXF74313.1 - 1.7e-06 27.9 2.2 0.0034 17.1 0.0 3.2 3 1 0 3 3 3 2 Redoxin Thioredoxin_3 PF13192.6 EXF74313.1 - 0.0091 16.0 0.2 0.049 13.7 0.1 2.3 2 0 0 2 2 2 1 Thioredoxin domain DSBA PF01323.20 EXF74313.1 - 0.028 14.2 0.3 13 5.5 0.0 4.0 3 1 0 3 3 3 0 DSBA-like thioredoxin domain Thioredoxin_4 PF13462.6 EXF74313.1 - 1.5 9.0 10.7 10 6.2 2.2 4.2 3 2 0 3 3 3 0 Thioredoxin TraF PF13728.6 EXF74313.1 - 9.1 6.0 8.1 14 5.4 0.0 3.2 2 1 1 3 3 3 0 F plasmid transfer operon protein RNA_polI_A34 PF08208.11 EXF74315.1 - 0.04 14.0 20.3 0.92 9.6 2.1 2.7 2 0 0 2 2 2 0 DNA-directed RNA polymerase I subunit RPA34.5 DUF1943 PF09172.11 EXF74315.1 - 4.1 6.6 7.0 9.1 5.4 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1943) CDC45 PF02724.14 EXF74315.1 - 5.2 5.2 10.5 5.4 5.2 9.5 1.5 1 1 0 1 1 1 0 CDC45-like protein U1snRNP70_N PF12220.8 EXF74315.1 - 7.6 7.3 14.6 7.1 7.3 7.5 2.6 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal Mon1 PF03164.14 EXF74316.1 - 1.5e-151 505.1 0.0 1.7e-151 504.9 0.0 1.0 1 0 0 1 1 1 1 Trafficking protein Mon1 Dopey_N PF04118.14 EXF74317.1 - 1.7e-115 385.3 0.0 5.3e-115 383.7 0.0 1.9 1 0 0 1 1 1 1 Dopey, N-terminal Methyltransf_15 PF09445.10 EXF74318.1 - 2.8e-47 160.3 0.0 3.9e-47 159.9 0.0 1.2 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Met_10 PF02475.16 EXF74318.1 - 3.3e-05 23.7 0.0 3.6e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein Cons_hypoth95 PF03602.15 EXF74318.1 - 0.0015 18.2 0.0 0.0025 17.5 0.0 1.4 1 1 0 1 1 1 1 Conserved hypothetical protein 95 UPF0020 PF01170.18 EXF74318.1 - 0.054 13.2 0.0 0.15 11.8 0.0 1.7 1 1 0 1 1 1 0 Putative RNA methylase family UPF0020 Methyltransf_25 PF13649.6 EXF74318.1 - 0.088 13.5 0.0 0.18 12.5 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_5 PF01795.19 EXF74318.1 - 0.23 10.9 0.0 0.31 10.5 0.0 1.1 1 0 0 1 1 1 0 MraW methylase family GRASP55_65 PF04495.14 EXF74319.1 - 2.6e-46 157.4 0.0 1e-45 155.4 0.0 1.8 2 0 0 2 2 2 1 GRASP55/65 PDZ-like domain PDZ_6 PF17820.1 EXF74319.1 - 0.003 17.4 0.2 0.26 11.2 0.1 2.6 2 0 0 2 2 2 1 PDZ domain PDZ_2 PF13180.6 EXF74319.1 - 0.11 12.8 0.0 0.24 11.8 0.0 1.6 1 0 0 1 1 1 0 PDZ domain DAD PF02109.16 EXF74320.1 - 2.1e-41 140.6 0.3 2.8e-41 140.2 0.3 1.1 1 0 0 1 1 1 1 DAD family NifW PF03206.14 EXF74320.1 - 0.12 12.9 0.0 0.26 11.8 0.0 1.5 1 0 0 1 1 1 0 Nitrogen fixation protein NifW DUF1180 PF06679.12 EXF74320.1 - 0.24 11.8 2.8 0.36 11.2 2.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Tmemb_14 PF03647.13 EXF74321.1 - 4.2e-24 85.1 5.3 4.7e-24 84.9 5.3 1.0 1 0 0 1 1 1 1 Transmembrane proteins 14C Aim19 PF10315.9 EXF74321.1 - 0.09 13.1 0.1 0.72 10.2 0.1 2.2 1 1 0 1 1 1 0 Altered inheritance of mitochondria protein 19 Cmc1 PF08583.10 EXF74322.1 - 1.1e-15 57.3 4.0 1.4e-15 57.0 4.0 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like bZIP_1 PF00170.21 EXF74322.1 - 0.31 11.2 9.0 0.49 10.5 9.0 1.2 1 0 0 1 1 1 0 bZIP transcription factor Prefoldin_2 PF01920.20 EXF74323.1 - 5.4e-24 84.2 11.0 6.6e-24 83.9 11.0 1.1 1 0 0 1 1 1 1 Prefoldin subunit IIGP PF05049.13 EXF74323.1 - 0.013 14.6 1.0 0.015 14.4 1.0 1.2 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) DUF2205 PF10224.9 EXF74323.1 - 0.033 14.2 2.3 0.033 14.2 2.3 2.1 2 0 0 2 2 2 0 Short coiled-coil protein DUF4757 PF15949.5 EXF74323.1 - 0.043 14.3 3.2 0.066 13.7 3.2 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4757) RUN PF02759.19 EXF74323.1 - 0.085 12.8 0.1 0.11 12.4 0.1 1.2 1 0 0 1 1 1 0 RUN domain Golgin_A5 PF09787.9 EXF74323.1 - 0.092 12.2 8.6 0.096 12.1 8.6 1.0 1 0 0 1 1 1 0 Golgin subfamily A member 5 MIP-T3_C PF17749.1 EXF74323.1 - 0.11 12.5 8.4 0.13 12.2 0.5 2.0 1 1 1 2 2 2 0 Microtubule-binding protein MIP-T3 C-terminal region SLATT_1 PF18181.1 EXF74323.1 - 0.33 10.9 2.3 0.5 10.3 0.5 1.9 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain 1 OmpH PF03938.14 EXF74323.1 - 3.9 7.8 14.7 2.1 8.7 1.5 2.1 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) CBFD_NFYB_HMF PF00808.23 EXF74324.1 - 3.5e-22 78.5 0.8 2.3e-14 53.4 0.2 2.3 2 0 0 2 2 2 2 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EXF74324.1 - 0.00097 19.5 0.1 0.032 14.6 0.1 2.3 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 RRN3 PF05327.11 EXF74325.1 - 2.7e-173 577.5 0.0 2.7e-173 577.5 0.0 1.6 2 0 0 2 2 2 1 RNA polymerase I specific transcription initiation factor RRN3 IBN_N PF03810.19 EXF74325.1 - 0.067 13.1 0.0 0.16 11.9 0.0 1.6 1 0 0 1 1 1 0 Importin-beta N-terminal domain PAC3 PF10178.9 EXF74325.1 - 0.084 13.0 0.0 0.3 11.3 0.0 1.9 1 0 0 1 1 1 0 Proteasome assembly chaperone 3 bZIP_1 PF00170.21 EXF74326.1 - 0.68 10.1 7.7 1.7 8.8 7.7 1.7 1 1 0 1 1 1 0 bZIP transcription factor Rad60-SLD_2 PF13881.6 EXF74327.1 - 5.9e-12 45.7 0.0 1.2e-11 44.7 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 EXF74327.1 - 0.00014 21.6 0.0 0.00027 20.6 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family DUF2407 PF10302.9 EXF74327.1 - 0.0023 18.5 0.0 0.0073 16.9 0.0 1.8 2 0 0 2 2 2 1 DUF2407 ubiquitin-like domain UMP1 PF05348.11 EXF74328.1 - 3e-43 146.8 0.0 3.5e-43 146.6 0.0 1.0 1 0 0 1 1 1 1 Proteasome maturation factor UMP1 ABC_tran PF00005.27 EXF74329.1 - 1.9e-22 80.3 0.0 1.2e-09 38.8 0.0 3.6 2 2 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 EXF74329.1 - 1.9e-07 31.2 0.1 0.092 12.5 0.1 3.5 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system SbcCD_C PF13558.6 EXF74329.1 - 1.4e-06 28.4 1.4 0.00067 19.8 0.1 2.7 3 0 0 3 3 2 2 Putative exonuclease SbcCD, C subunit AAA_23 PF13476.6 EXF74329.1 - 0.00012 22.6 0.3 0.33 11.4 0.1 2.2 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 EXF74329.1 - 0.0002 21.6 0.0 1.3 9.3 0.0 3.0 4 0 0 4 4 3 2 AAA domain AAA_29 PF13555.6 EXF74329.1 - 0.00047 19.9 0.1 0.59 9.9 0.0 2.4 2 0 0 2 2 2 2 P-loop containing region of AAA domain TniB PF05621.11 EXF74329.1 - 0.0031 16.9 0.0 0.26 10.7 0.0 2.2 2 0 0 2 2 2 1 Bacterial TniB protein AAA_24 PF13479.6 EXF74329.1 - 0.0079 15.9 0.0 3.6 7.2 0.0 2.2 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EXF74329.1 - 0.021 15.2 0.0 6.1 7.2 0.0 2.5 2 0 0 2 2 2 0 AAA ATPase domain AAA_33 PF13671.6 EXF74329.1 - 0.022 14.9 0.1 1.4 9.1 0.0 2.4 2 0 0 2 2 2 0 AAA domain Ploopntkinase1 PF18748.1 EXF74329.1 - 0.044 13.3 0.0 0.075 12.5 0.0 1.3 1 0 0 1 1 1 0 P-loop Nucleotide Kinase1 ATPase_2 PF01637.18 EXF74329.1 - 0.074 13.0 0.0 14 5.5 0.0 2.2 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea RNA_helicase PF00910.22 EXF74329.1 - 0.094 13.1 0.0 2.4 8.6 0.0 2.4 2 0 0 2 2 2 0 RNA helicase AAA PF00004.29 EXF74329.1 - 0.11 13.0 0.2 1.6 9.1 0.0 2.8 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 EXF74329.1 - 0.13 12.3 0.0 6.5 6.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 EXF74329.1 - 0.14 12.7 0.1 5.9 7.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain SMC_N PF02463.19 EXF74329.1 - 0.2 11.0 0.1 3.9 6.9 0.0 2.5 3 0 0 3 3 3 0 RecF/RecN/SMC N terminal domain PduV-EutP PF10662.9 EXF74329.1 - 0.26 11.0 0.0 2 8.1 0.0 2.0 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Chitin_synth_1 PF01644.17 EXF74330.1 - 1.8e-76 255.7 0.0 3.2e-76 254.8 0.0 1.4 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.11 EXF74330.1 - 9.4e-28 96.0 0.2 2.4e-27 94.7 0.2 1.8 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.15 EXF74330.1 - 4.4e-22 78.4 2.1 4.7e-19 68.4 0.0 2.3 2 0 0 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.6 EXF74330.1 - 9.3e-09 35.5 0.2 9.3e-09 35.5 0.2 2.2 3 1 0 3 3 3 1 Glycosyl transferase family group 2 Tyosinase_C PF18132.1 EXF74331.1 - 5.9e-34 117.3 0.0 9.6e-34 116.7 0.0 1.3 1 0 0 1 1 1 1 Tyosinase C-terminal domain Tyrosinase PF00264.20 EXF74331.1 - 1.8e-30 106.9 0.2 3.7e-30 105.9 0.2 1.5 1 0 0 1 1 1 1 Common central domain of tyrosinase Tannase PF07519.11 EXF74332.1 - 8.6e-147 489.8 8.4 1e-146 489.6 8.4 1.0 1 0 0 1 1 1 1 Tannase and feruloyl esterase MFS_1 PF07690.16 EXF74333.1 - 9.2e-09 34.7 6.9 1.6e-07 30.6 8.6 1.8 2 0 0 2 2 2 1 Major Facilitator Superfamily Zip PF02535.22 EXF74333.1 - 0.074 12.3 2.0 0.15 11.2 0.1 2.0 1 1 1 2 2 2 0 ZIP Zinc transporter PspB PF06667.12 EXF74333.1 - 0.075 13.1 0.7 0.36 10.9 0.0 2.3 2 0 0 2 2 2 0 Phage shock protein B PcfK PF14058.6 EXF74333.1 - 0.11 12.8 0.1 0.17 12.2 0.1 1.2 1 0 0 1 1 1 0 PcfK-like protein DUF4064 PF13273.6 EXF74333.1 - 9.1 6.6 8.5 17 5.7 0.8 3.6 3 1 1 4 4 4 0 Protein of unknown function (DUF4064) Asparaginase_2 PF01112.18 EXF74334.1 - 1.3e-72 244.4 7.8 1.7e-72 244.1 7.8 1.0 1 0 0 1 1 1 1 Asparaginase Aminotran_3 PF00202.21 EXF74335.1 - 4.1e-48 164.0 0.0 7.7e-27 94.0 0.0 2.1 2 0 0 2 2 2 2 Aminotransferase class-III MFS_1 PF07690.16 EXF74336.1 - 5.2e-45 153.9 30.8 5.2e-45 153.9 30.8 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF74336.1 - 1.9e-12 46.8 12.4 1.9e-12 46.8 12.4 2.2 3 0 0 3 3 3 1 Sugar (and other) transporter TRI12 PF06609.13 EXF74336.1 - 9.8e-06 24.3 6.5 1.7e-05 23.5 6.5 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_1_like PF12832.7 EXF74336.1 - 0.00084 18.3 3.8 0.0015 17.5 0.2 2.6 2 0 0 2 2 2 1 MFS_1 like family MFS_3 PF05977.13 EXF74336.1 - 1.7 6.9 16.1 0.082 11.3 7.9 2.1 2 0 0 2 2 2 0 Transmembrane secretion effector DUF2076 PF09849.9 EXF74337.1 - 1.6 8.7 4.2 0.44 10.5 1.2 1.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2076) SnoaL_3 PF13474.6 EXF74339.1 - 9.4e-07 29.1 0.1 1.2e-06 28.8 0.1 1.1 1 0 0 1 1 1 1 SnoaL-like domain SnoaL_4 PF13577.6 EXF74339.1 - 5.7e-06 26.5 0.1 1.1e-05 25.5 0.1 1.5 1 1 0 1 1 1 1 SnoaL-like domain SnoaL_2 PF12680.7 EXF74339.1 - 6.1e-06 26.8 0.0 8.3e-06 26.4 0.0 1.2 1 0 0 1 1 1 1 SnoaL-like domain DUF4440 PF14534.6 EXF74339.1 - 7e-05 23.2 0.1 9.2e-05 22.8 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) NTF2 PF02136.20 EXF74339.1 - 0.019 15.5 0.0 0.031 14.8 0.0 1.4 1 1 0 1 1 1 0 Nuclear transport factor 2 (NTF2) domain SnoaL PF07366.12 EXF74339.1 - 0.041 13.7 0.0 0.054 13.3 0.0 1.2 1 0 0 1 1 1 0 SnoaL-like polyketide cyclase peroxidase PF00141.23 EXF74340.1 - 4.8e-85 284.9 0.0 7.6e-46 156.7 0.0 2.3 2 0 0 2 2 2 2 Peroxidase GST_C_3 PF14497.6 EXF74340.1 - 0.031 14.5 0.0 11 6.3 0.0 2.6 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain Amidohydro_1 PF01979.20 EXF74341.1 - 1.5e-08 34.4 1.2 6.6e-08 32.3 1.2 2.0 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EXF74341.1 - 2e-05 24.3 3.8 0.00042 19.9 1.5 2.5 2 1 0 2 2 2 2 Amidohydrolase family IalB PF06776.12 EXF74341.1 - 0.13 12.3 0.0 0.38 10.8 0.0 1.8 2 0 0 2 2 2 0 Invasion associated locus B (IalB) protein PAF-AH_p_II PF03403.13 EXF74342.1 - 1e-18 67.0 0.1 8.1e-15 54.2 0.1 2.1 1 1 0 1 1 1 1 Platelet-activating factor acetylhydrolase, isoform II Chlorophyllase2 PF12740.7 EXF74342.1 - 3.7e-06 26.0 0.0 7.9e-06 25.0 0.0 1.5 1 1 0 1 1 1 1 Chlorophyllase enzyme Hydrolase_4 PF12146.8 EXF74342.1 - 0.0036 16.6 0.4 0.53 9.5 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_5 PF12695.7 EXF74342.1 - 0.035 13.9 0.1 0.47 10.2 0.0 2.1 2 0 0 2 2 2 0 Alpha/beta hydrolase family Abhydrolase_6 PF12697.7 EXF74342.1 - 0.036 14.7 0.1 0.065 13.8 0.1 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase family Chlorophyllase PF07224.11 EXF74342.1 - 0.11 11.5 0.0 1.8 7.5 0.0 2.1 2 0 0 2 2 2 0 Chlorophyllase Abhydrolase_3 PF07859.13 EXF74342.1 - 0.15 11.9 0.0 0.23 11.3 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EXF74342.1 - 0.15 11.5 0.0 0.28 10.6 0.0 1.4 1 0 0 1 1 1 0 Prolyl oligopeptidase family Acetyltransf_10 PF13673.7 EXF74343.1 - 1.7e-05 24.8 0.0 2.2e-05 24.4 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EXF74343.1 - 0.0011 19.2 0.0 0.0015 18.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_9 PF13527.7 EXF74343.1 - 0.012 15.7 0.8 0.04 14.0 0.8 1.9 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain PorA PF11271.8 EXF74343.1 - 0.051 12.9 0.1 0.06 12.6 0.1 1.1 1 0 0 1 1 1 0 Porin PorA Cutinase PF01083.22 EXF74344.1 - 2.9e-29 102.3 0.7 2.9e-29 102.3 0.7 1.5 2 0 0 2 2 2 1 Cutinase Sporozoite_P67 PF05642.11 EXF74344.1 - 0.087 10.9 8.3 0.11 10.6 8.3 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Kelch_3 PF13415.6 EXF74344.1 - 0.42 11.0 3.8 2.4 8.5 3.8 2.4 1 1 0 1 1 1 0 Galactose oxidase, central domain TraG-D_C PF12696.7 EXF74344.1 - 1 9.4 3.3 1.8 8.5 3.3 1.4 1 0 0 1 1 1 0 TraM recognition site of TraD and TraG MGC-24 PF05283.11 EXF74344.1 - 1.8 9.0 10.2 3.8 8.0 10.2 1.6 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin MSA-2c PF12238.8 EXF74344.1 - 4.2 7.3 8.3 6.4 6.7 8.3 1.2 1 0 0 1 1 1 0 Merozoite surface antigen 2c Peptidase_M28 PF04389.17 EXF74345.1 - 6.9e-37 127.1 0.0 1.1e-36 126.4 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 EXF74345.1 - 1.6e-10 40.9 1.6 3.4e-10 39.8 1.6 1.6 1 0 0 1 1 1 1 PA domain Peptidase_M20 PF01546.28 EXF74345.1 - 3.5e-05 23.6 0.0 9.2e-05 22.2 0.0 1.7 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 Ribosomal_L36e PF01158.18 EXF74347.1 - 0.058 13.6 1.4 0.21 11.9 1.4 1.9 1 0 0 1 1 1 0 Ribosomal protein L36e DEAD PF00270.29 EXF74348.1 - 2.5e-44 151.1 0.1 4.1e-44 150.4 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EXF74348.1 - 7.5e-18 64.9 0.0 2.2e-17 63.4 0.0 1.9 1 1 0 1 1 1 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EXF74348.1 - 2.7e-15 56.3 0.2 5.8e-15 55.3 0.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 EXF74348.1 - 8.6e-07 29.1 0.0 2.3e-06 27.7 0.0 1.6 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit IBR PF01485.21 EXF74349.1 - 2.8e-16 59.5 29.3 8.1e-09 35.6 5.4 3.5 3 0 0 3 3 3 3 IBR domain, a half RING-finger domain zf-C3HC4 PF00097.25 EXF74349.1 - 0.00077 19.3 0.1 0.00077 19.3 0.1 3.9 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EXF74349.1 - 0.01 15.6 0.1 0.01 15.6 0.1 4.1 3 1 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EXF74349.1 - 0.037 14.0 1.0 0.037 14.0 1.0 4.0 3 1 0 3 3 3 0 zinc-RING finger domain zf-RING_2 PF13639.6 EXF74349.1 - 0.04 14.3 0.6 0.04 14.3 0.6 4.0 3 1 0 3 3 3 0 Ring finger domain GHMP_kinases_N PF00288.26 EXF74350.1 - 1.9e-15 56.8 3.2 5.1e-15 55.5 3.2 1.7 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 EXF74350.1 - 4.3e-08 33.4 0.3 1e-07 32.2 0.3 1.6 1 0 0 1 1 1 1 GHMP kinases C terminal BST2 PF16716.5 EXF74350.1 - 0.11 13.1 0.1 0.22 12.2 0.1 1.4 1 0 0 1 1 1 0 Bone marrow stromal antigen 2 PPR_2 PF13041.6 EXF74351.1 - 2.2e-43 146.2 12.4 1.6e-08 34.6 0.0 14.6 10 3 5 15 15 15 7 PPR repeat family PPR_3 PF13812.6 EXF74351.1 - 3.1e-30 104.1 0.9 0.0025 17.9 0.0 10.5 7 2 4 12 12 12 7 Pentatricopeptide repeat domain PPR PF01535.20 EXF74351.1 - 7.3e-23 79.2 34.2 0.0012 19.0 0.1 14.4 18 0 0 18 18 18 7 PPR repeat PPR_1 PF12854.7 EXF74351.1 - 1.9e-19 69.0 0.0 1.4e-07 31.1 0.0 9.4 10 0 0 10 10 10 3 PPR repeat PPR_long PF17177.4 EXF74351.1 - 1.1e-16 60.9 15.9 3.5e-07 29.8 0.3 6.1 4 2 2 6 6 6 4 Pentacotripeptide-repeat region of PRORP RPM2 PF08579.11 EXF74351.1 - 3.2e-05 24.3 0.0 0.0016 18.8 0.0 3.5 4 0 0 4 4 4 1 Mitochondrial ribonuclease P subunit (RPM2) ATP13 PF12921.7 EXF74351.1 - 0.0021 17.9 0.2 0.2 11.5 0.1 3.7 4 1 0 4 4 4 1 Mitochondrial ATPase expression TPR_7 PF13176.6 EXF74351.1 - 0.3 11.2 1.4 32 4.9 0.0 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat MIF4G PF02854.19 EXF74353.1 - 2.4e-58 197.3 0.0 4e-31 108.3 0.0 3.5 3 1 0 3 3 3 2 MIF4G domain Upf2 PF04050.14 EXF74353.1 - 1.3e-42 145.7 6.5 1.3e-42 145.7 6.5 2.7 2 0 0 2 2 2 1 Up-frameshift suppressor 2 Astro_capsid_p PF12226.8 EXF74353.1 - 0.015 14.5 10.0 0.033 13.4 10.0 1.5 1 0 0 1 1 1 0 Turkey astrovirus capsid protein CBP4 PF07960.11 EXF74353.1 - 0.06 13.2 0.0 0.06 13.2 0.0 2.6 3 0 0 3 3 3 0 CBP4 CDC45 PF02724.14 EXF74353.1 - 0.63 8.3 12.0 0.33 9.2 9.8 1.6 1 1 0 1 1 1 0 CDC45-like protein DUF349 PF03993.12 EXF74353.1 - 6.4 7.1 8.8 23 5.4 5.1 3.3 2 1 0 2 2 2 0 Domain of Unknown Function (DUF349) Mo-co_dimer PF03404.16 EXF74354.1 - 5.2e-61 204.7 0.1 1.1e-60 203.7 0.1 1.5 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain Oxidored_molyb PF00174.19 EXF74354.1 - 2.6e-55 186.7 0.0 4.2e-55 186.0 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain FAD_binding_6 PF00970.24 EXF74354.1 - 2.1e-33 114.6 0.0 4.5e-33 113.5 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 EXF74354.1 - 1e-23 84.0 0.0 2.9e-23 82.6 0.0 1.8 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain Cyt-b5 PF00173.28 EXF74354.1 - 1.4e-17 63.6 0.0 3.2e-17 62.4 0.0 1.7 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain NAD_binding_6 PF08030.12 EXF74354.1 - 0.012 15.7 0.0 0.086 13.0 0.0 2.1 2 0 0 2 2 2 0 Ferric reductase NAD binding domain Na_Ca_ex PF01699.24 EXF74355.1 - 6.7e-27 94.3 25.9 2.2e-13 50.4 6.9 2.1 2 0 0 2 2 2 2 Sodium/calcium exchanger protein 7tm_7 PF08395.12 EXF74355.1 - 0.016 14.4 0.0 0.016 14.4 0.0 2.6 2 1 2 4 4 4 0 7tm Chemosensory receptor DUF4536 PF15055.6 EXF74355.1 - 0.03 14.6 0.6 0.03 14.6 0.6 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4536) DUF1298 PF06974.13 EXF74355.1 - 0.14 12.1 0.0 0.3 11.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1298) DUF5337 PF17272.2 EXF74355.1 - 0.16 11.8 1.2 1.3 8.9 0.1 2.8 2 0 0 2 2 2 0 Family of unknown function (DUF5337) Na_Ala_symp PF01235.17 EXF74355.1 - 5.3 6.2 14.5 1 8.6 0.2 3.1 2 1 0 3 3 3 0 Sodium:alanine symporter family DEAD PF00270.29 EXF74357.1 - 1.4e-29 103.1 0.0 3.2e-29 101.9 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF1998 PF09369.10 EXF74357.1 - 1.3e-20 73.9 0.2 3.9e-20 72.4 0.2 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF1998) Helicase_C PF00271.31 EXF74357.1 - 1.1e-11 45.0 0.0 7e-11 42.5 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EXF74357.1 - 1.2e-07 31.9 0.0 2.4e-07 30.9 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CDT1 PF08839.11 EXF74357.1 - 2.9e-06 27.7 0.3 8.3e-06 26.2 0.3 1.9 1 1 0 1 1 1 1 DNA replication factor CDT1 like TMCO5 PF14992.6 EXF74357.1 - 0.032 13.8 0.1 0.076 12.6 0.1 1.5 1 0 0 1 1 1 0 TMCO5 family Ran_BP1 PF00638.18 EXF74358.1 - 1.7e-11 44.5 0.1 0.0002 21.6 0.0 2.5 2 0 0 2 2 2 2 RanBP1 domain SDA1 PF05285.12 EXF74358.1 - 3.1 7.1 31.7 0.49 9.8 6.7 2.1 2 0 0 2 2 2 0 SDA1 Yip1 PF04893.17 EXF74359.1 - 5.7e-12 45.7 17.2 8e-12 45.2 17.0 1.4 1 1 0 1 1 1 1 Yip1 domain DUF1282 PF06930.12 EXF74359.1 - 0.044 13.6 4.9 0.076 12.8 4.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1282) PAS_3 PF08447.12 EXF74360.1 - 1.8e-16 60.2 0.0 2.1e-12 47.2 0.0 2.5 2 0 0 2 2 2 2 PAS fold PAS_9 PF13426.7 EXF74360.1 - 3.7e-10 40.0 0.0 5.6e-07 29.8 0.0 2.8 3 0 0 3 3 3 2 PAS domain PAS PF00989.25 EXF74360.1 - 5.3e-07 29.6 0.0 0.00059 19.8 0.0 2.5 2 0 0 2 2 2 2 PAS fold PAS_11 PF14598.6 EXF74360.1 - 2e-05 24.7 0.0 6.2e-05 23.1 0.0 1.8 2 0 0 2 2 2 1 PAS domain PAS_4 PF08448.10 EXF74360.1 - 0.00055 20.2 0.0 0.073 13.3 0.0 2.6 2 0 0 2 2 2 1 PAS fold YL1 PF05764.13 EXF74360.1 - 0.085 13.0 2.2 0.14 12.3 2.2 1.3 1 0 0 1 1 1 0 YL1 nuclear protein Med13_C PF06333.12 EXF74360.1 - 0.37 10.0 0.0 0.37 10.0 0.0 2.5 3 0 0 3 3 3 0 Mediator complex subunit 13 C-terminal domain SDA1 PF05285.12 EXF74360.1 - 3.4 7.0 6.3 4.9 6.5 6.3 1.1 1 0 0 1 1 1 0 SDA1 WD40 PF00400.32 EXF74361.1 - 7.6e-13 48.7 17.9 1.2e-05 25.9 0.6 6.2 7 0 0 7 7 7 4 WD domain, G-beta repeat RNA_pol_I_TF PF04090.12 EXF74362.1 - 7.9e-05 22.2 0.0 0.046 13.2 0.0 2.2 2 0 0 2 2 2 2 RNA polymerase I specific initiation factor BAR_2 PF10455.9 EXF74363.1 - 4.2e-58 196.8 0.0 6.5e-58 196.1 0.0 1.3 1 0 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking ETC_C1_NDUFA5 PF04716.14 EXF74363.1 - 8.3e-25 86.4 1.8 1.8e-23 82.1 0.2 2.9 2 0 0 2 2 2 1 ETC complex I subunit conserved region BAR PF03114.18 EXF74363.1 - 2e-22 80.0 1.4 5.7e-21 75.3 1.4 2.4 1 1 0 1 1 1 1 BAR domain BAR_3 PF16746.5 EXF74363.1 - 0.0051 16.5 0.1 0.033 13.9 0.0 2.3 2 1 0 2 2 2 1 BAR domain of APPL family YdjC PF04794.12 EXF74363.1 - 0.093 12.7 0.3 0.38 10.7 0.2 2.1 2 1 0 2 2 2 0 YdjC-like protein NAT PF04768.13 EXF74364.1 - 9e-50 168.6 0.0 3.5e-49 166.7 0.0 1.8 2 0 0 2 2 2 1 NAT, N-acetyltransferase, of N-acetylglutamate synthase NAD_binding_2 PF03446.15 EXF74365.1 - 1.2e-27 97.1 0.1 1.8e-27 96.4 0.1 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 EXF74365.1 - 3.3e-12 46.7 0.4 1.8e-10 41.1 0.0 2.2 2 0 0 2 2 2 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase Shikimate_DH PF01488.20 EXF74365.1 - 2.7e-09 37.2 0.0 1e-08 35.3 0.0 1.9 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.17 EXF74365.1 - 5e-09 36.6 0.1 1.3e-08 35.3 0.1 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Sacchrp_dh_NADP PF03435.18 EXF74365.1 - 0.00031 21.0 0.1 0.00069 19.9 0.1 1.7 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_3 PF03447.16 EXF74365.1 - 0.00061 20.4 0.2 0.0016 19.1 0.1 1.7 1 1 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 EXF74365.1 - 0.0016 17.8 0.0 0.0025 17.2 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain HTH_Tnp_Mu_2 PF09039.11 EXF74365.1 - 0.0093 16.0 0.0 0.04 14.0 0.0 1.9 2 0 0 2 2 2 1 Mu DNA binding, I gamma subdomain TrkA_N PF02254.18 EXF74365.1 - 0.017 15.4 0.2 0.053 13.8 0.2 1.9 1 1 0 1 1 1 0 TrkA-N domain KR PF08659.10 EXF74365.1 - 0.022 14.7 0.2 0.31 11.0 0.1 2.4 2 1 1 3 3 3 0 KR domain UDPG_MGDP_dh_N PF03721.14 EXF74365.1 - 0.027 14.0 0.3 0.12 11.9 0.2 2.2 2 1 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Semialdhyde_dh PF01118.24 EXF74365.1 - 0.044 14.2 0.0 0.1 13.1 0.0 1.7 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain GFO_IDH_MocA PF01408.22 EXF74365.1 - 0.045 14.6 0.0 0.091 13.6 0.0 1.5 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold ATP_synt_H PF05493.13 EXF74366.1 - 5.3e-24 84.5 1.4 6e-24 84.3 1.4 1.0 1 0 0 1 1 1 1 ATP synthase subunit H 7TM-7TMR_HD PF07698.11 EXF74366.1 - 0.013 15.3 0.2 0.014 15.2 0.2 1.0 1 0 0 1 1 1 0 7TM receptor with intracellular HD hydrolase DUF4131 PF13567.6 EXF74366.1 - 0.029 14.0 1.3 0.03 14.0 1.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) DUF2070 PF09843.9 EXF74366.1 - 0.073 11.4 0.1 0.078 11.3 0.1 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) ARL6IP6 PF15062.6 EXF74366.1 - 0.13 12.4 0.1 0.18 12.0 0.1 1.3 1 1 0 1 1 1 0 Haemopoietic lineage transmembrane helix Flavi_NS4A PF01350.17 EXF74366.1 - 0.14 12.0 0.5 0.17 11.8 0.5 1.1 1 0 0 1 1 1 0 Flavivirus non-structural protein NS4A Arv1 PF04161.13 EXF74367.1 - 3.3e-79 265.9 0.7 4e-79 265.6 0.7 1.1 1 0 0 1 1 1 1 Arv1-like family LysM PF01476.20 EXF74368.1 - 0.025 14.6 0.0 0.045 13.8 0.0 1.5 1 0 0 1 1 1 0 LysM domain Fungal_trans PF04082.18 EXF74369.1 - 1.2e-38 132.7 0.0 4.6e-38 130.8 0.0 2.0 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF74369.1 - 1e-07 31.9 8.3 1.8e-07 31.2 8.3 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain GHMP_kinases_N PF00288.26 EXF74369.1 - 0.18 12.1 3.4 0.51 10.6 3.4 1.8 1 0 0 1 1 1 0 GHMP kinases N terminal domain PigN PF04987.14 EXF74370.1 - 9.3e-164 545.6 33.8 9.3e-164 545.6 33.8 1.7 2 0 0 2 2 2 1 Phosphatidylinositolglycan class N (PIG-N) Phosphodiest PF01663.22 EXF74370.1 - 1.7e-08 34.5 4.7 6.9e-07 29.2 4.6 2.1 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 EXF74370.1 - 4.2e-08 32.9 0.1 6.8e-08 32.3 0.1 1.3 1 0 0 1 1 1 1 Sulfatase Metalloenzyme PF01676.18 EXF74370.1 - 2e-05 24.1 0.0 3.2e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 Metalloenzyme superfamily Csm1 PF12539.8 EXF74371.1 - 8.7e-33 112.8 0.0 1.6e-32 111.9 0.0 1.5 1 0 0 1 1 1 1 Chromosome segregation protein Csm1/Pcs1 Macoilin PF09726.9 EXF74371.1 - 0.00036 19.2 20.4 0.00048 18.8 20.4 1.1 1 0 0 1 1 1 1 Macoilin family UPF0242 PF06785.11 EXF74371.1 - 0.0011 19.2 2.3 0.0011 19.2 2.3 2.0 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0242) N-terminus V_ATPase_I PF01496.19 EXF74371.1 - 0.0054 14.7 0.7 0.0054 14.7 0.7 1.5 2 0 0 2 2 2 1 V-type ATPase 116kDa subunit family Sulfatase_C PF14707.6 EXF74371.1 - 0.0058 17.4 0.3 0.013 16.2 0.3 1.5 1 0 0 1 1 1 1 C-terminal region of aryl-sulfatase TACC_C PF05010.14 EXF74371.1 - 0.0086 15.9 6.0 0.0086 15.9 6.0 1.7 2 0 0 2 2 2 1 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Spc7 PF08317.11 EXF74371.1 - 0.011 14.7 7.9 0.021 13.7 7.9 1.5 1 0 0 1 1 1 0 Spc7 kinetochore protein FemAB PF02388.16 EXF74371.1 - 0.012 14.5 4.4 0.026 13.4 4.4 1.5 1 0 0 1 1 1 0 FemAB family DUF2664 PF10867.8 EXF74371.1 - 0.035 14.5 0.6 0.087 13.3 0.6 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2664) PilO PF04350.13 EXF74371.1 - 0.092 12.9 1.9 0.22 11.7 1.9 1.7 1 0 0 1 1 1 0 Pilus assembly protein, PilO GAS PF13851.6 EXF74371.1 - 0.12 11.7 9.6 0.92 8.8 9.7 2.2 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Rootletin PF15035.6 EXF74371.1 - 0.15 12.1 7.5 0.34 10.9 7.5 1.5 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion Fib_alpha PF08702.10 EXF74371.1 - 0.18 12.0 1.4 0.63 10.2 1.4 2.0 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Atg14 PF10186.9 EXF74371.1 - 0.28 10.2 6.7 0.53 9.3 6.7 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF5094 PF17015.5 EXF74371.1 - 0.35 11.0 0.1 0.35 11.0 0.1 4.1 3 2 1 4 4 4 0 Domain of unknown function (DUF5094) TPR_MLP1_2 PF07926.12 EXF74371.1 - 0.66 10.0 15.0 3.5 7.7 15.0 2.2 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein Nup88 PF10168.9 EXF74371.1 - 0.75 7.5 5.3 1.4 6.7 5.3 1.3 1 0 0 1 1 1 0 Nuclear pore component HIP1_clath_bdg PF16515.5 EXF74371.1 - 1 10.0 11.4 33 5.2 10.9 2.9 1 1 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 CENP-B_dimeris PF09026.10 EXF74371.1 - 1.2 9.5 11.3 3.2 8.2 0.7 2.6 2 0 0 2 2 2 0 Centromere protein B dimerisation domain BST2 PF16716.5 EXF74371.1 - 4.5 7.9 16.0 0.087 13.4 7.6 2.5 3 0 0 3 3 2 0 Bone marrow stromal antigen 2 FTA4 PF13093.6 EXF74371.1 - 8.4 6.2 11.7 3.3 7.6 7.9 2.1 2 1 0 2 2 2 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 AAA PF00004.29 EXF74372.1 - 4.3e-38 130.7 0.0 7.7e-38 129.9 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EXF74372.1 - 1.7e-07 30.9 0.0 3.5e-07 29.9 0.0 1.5 1 0 0 1 1 1 1 AAA+ lid domain RuvB_N PF05496.12 EXF74372.1 - 4.7e-06 26.4 0.0 1.6e-05 24.7 0.0 1.9 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EXF74372.1 - 6.8e-06 26.6 0.1 0.00038 20.9 0.0 2.5 1 1 1 2 2 2 1 AAA ATPase domain AAA_14 PF13173.6 EXF74372.1 - 1.5e-05 25.1 0.0 2.8e-05 24.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 EXF74372.1 - 3.5e-05 23.8 0.1 0.00028 20.9 0.1 2.5 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EXF74372.1 - 3.8e-05 24.0 0.1 0.0049 17.1 0.0 3.0 1 1 2 3 3 3 1 AAA domain AAA_2 PF07724.14 EXF74372.1 - 7.6e-05 22.9 0.0 0.00013 22.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) TniB PF05621.11 EXF74372.1 - 0.00042 19.8 0.0 0.77 9.1 0.0 2.7 2 1 0 3 3 2 2 Bacterial TniB protein Mg_chelatase PF01078.21 EXF74372.1 - 0.0018 17.7 0.1 0.0038 16.6 0.1 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 EXF74372.1 - 0.0037 17.4 0.0 0.0067 16.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 EXF74372.1 - 0.0043 17.4 0.0 0.013 15.9 0.0 1.9 2 0 0 2 2 1 1 RNA helicase AAA_25 PF13481.6 EXF74372.1 - 0.0047 16.5 0.1 0.07 12.7 0.1 2.4 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 EXF74372.1 - 0.0056 16.4 0.0 0.0097 15.7 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein DUF815 PF05673.13 EXF74372.1 - 0.0064 15.7 0.0 0.013 14.6 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) NACHT PF05729.12 EXF74372.1 - 0.0099 15.8 0.0 0.021 14.7 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_18 PF13238.6 EXF74372.1 - 0.013 16.1 0.1 0.039 14.5 0.0 2.0 2 0 0 2 2 1 0 AAA domain Sigma54_activat PF00158.26 EXF74372.1 - 0.015 15.0 0.0 0.035 13.8 0.0 1.5 2 0 0 2 2 1 0 Sigma-54 interaction domain AAA_24 PF13479.6 EXF74372.1 - 0.023 14.4 0.0 0.037 13.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 EXF74372.1 - 0.023 13.9 0.0 0.16 11.1 0.0 2.0 2 0 0 2 2 2 0 NB-ARC domain ATPase_2 PF01637.18 EXF74372.1 - 0.024 14.6 0.0 0.15 12.0 0.0 2.1 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea Sigma54_activ_2 PF14532.6 EXF74372.1 - 0.026 14.7 0.0 0.067 13.3 0.0 1.7 1 0 0 1 1 1 0 Sigma-54 interaction domain TOM6p PF15184.6 EXF74372.1 - 0.027 14.2 0.2 0.057 13.2 0.2 1.5 1 0 0 1 1 1 0 Mitochondrial import receptor subunit TOM6 homolog AAA_28 PF13521.6 EXF74372.1 - 0.034 14.4 0.2 0.11 12.7 0.0 2.0 3 0 0 3 3 1 0 AAA domain Rad17 PF03215.15 EXF74372.1 - 0.035 14.0 0.0 0.11 12.4 0.0 1.6 1 1 1 2 2 2 0 Rad17 P-loop domain TIP49 PF06068.13 EXF74372.1 - 0.057 12.6 0.0 0.11 11.7 0.0 1.4 1 0 0 1 1 1 0 TIP49 P-loop domain Guanylate_kin PF00625.21 EXF74372.1 - 0.063 13.0 0.1 0.48 10.1 0.0 2.4 2 1 0 2 2 2 0 Guanylate kinase Zeta_toxin PF06414.12 EXF74372.1 - 0.064 12.5 0.2 0.14 11.4 0.0 1.6 2 0 0 2 2 1 0 Zeta toxin AAA_7 PF12775.7 EXF74372.1 - 0.068 12.7 0.0 0.13 11.8 0.0 1.4 1 1 0 1 1 1 0 P-loop containing dynein motor region TsaE PF02367.17 EXF74372.1 - 0.1 12.6 0.0 0.19 11.8 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_tran PF00005.27 EXF74372.1 - 0.11 13.0 0.0 0.22 12.0 0.0 1.7 1 1 0 1 1 1 0 ABC transporter Bac_DnaA PF00308.18 EXF74372.1 - 0.12 12.2 0.0 0.22 11.3 0.0 1.4 1 0 0 1 1 1 0 Bacterial dnaA protein Parvo_NS1 PF01057.17 EXF74372.1 - 0.12 11.4 0.0 0.21 10.6 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_17 PF13207.6 EXF74372.1 - 0.13 12.7 0.1 0.33 11.4 0.1 1.7 1 0 0 1 1 1 0 AAA domain zf-C2H2 PF00096.26 EXF74373.1 - 6.1e-06 26.4 11.6 0.0027 18.1 1.6 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EXF74373.1 - 0.00028 21.2 3.8 0.00028 21.2 3.8 2.5 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 EXF74373.1 - 0.00028 21.5 11.0 0.075 13.9 2.9 3.0 2 0 0 2 2 2 2 C2H2-type zinc finger PBP1_TM PF14812.6 EXF74373.1 - 6.4 7.2 6.9 15 6.0 6.9 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Tannase PF07519.11 EXF74374.1 - 1.8e-48 165.6 0.0 1.5e-30 106.6 0.0 2.3 2 1 1 3 3 3 2 Tannase and feruloyl esterase Glyco_hydro_47 PF01532.20 EXF74375.1 - 5.5e-174 579.4 0.0 6.4e-174 579.2 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 COesterase PF00135.28 EXF74376.1 - 1.6e-56 192.3 6.6 8.4e-56 189.9 6.6 1.9 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EXF74376.1 - 0.0035 17.2 1.3 0.028 14.3 0.3 2.6 2 1 0 2 2 2 1 alpha/beta hydrolase fold Ank_2 PF12796.7 EXF74377.1 - 1.9e-05 25.2 0.0 3.9e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EXF74377.1 - 2.7e-05 24.4 0.1 5.9e-05 23.3 0.1 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EXF74377.1 - 3e-05 24.1 0.0 0.069 13.7 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.6 EXF74377.1 - 0.00032 21.2 0.0 0.055 14.1 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 EXF74377.1 - 0.00036 20.8 0.0 0.12 12.8 0.0 2.7 2 0 0 2 2 2 1 Ankyrin repeat Noggin PF05806.12 EXF74377.1 - 0.11 12.3 0.0 0.85 9.5 0.0 2.0 2 0 0 2 2 2 0 Noggin Candida_ALS PF05792.13 EXF74379.1 - 0.0025 18.4 12.5 0.0025 18.4 12.5 16.2 14 4 0 14 14 14 8 Candida agglutinin-like (ALS) Glyco_hydro_75 PF07335.11 EXF74381.1 - 5.6e-68 228.3 0.3 7.6e-68 227.9 0.3 1.2 1 0 0 1 1 1 1 Fungal chitosanase of glycosyl hydrolase group 75 Sugar_tr PF00083.24 EXF74383.1 - 5.2e-100 335.4 29.0 6.5e-100 335.1 29.0 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF74383.1 - 2e-25 89.5 57.7 8e-23 80.9 28.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Trp_oprn_chp PF09534.10 EXF74383.1 - 0.022 14.5 1.3 5.4 6.8 0.2 2.5 2 0 0 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Aspzincin_M35 PF14521.6 EXF74384.1 - 4.3e-36 124.6 3.8 1.3e-35 123.0 3.8 1.9 1 0 0 1 1 1 1 Lysine-specific metallo-endopeptidase Peptidase_M35 PF02102.15 EXF74384.1 - 1.9e-28 99.4 16.1 2.8e-28 98.8 16.1 1.2 1 0 0 1 1 1 1 Deuterolysin metalloprotease (M35) family HRXXH PF13933.6 EXF74384.1 - 3.9e-05 23.3 2.2 3.9e-05 23.3 2.2 1.9 2 0 0 2 2 2 1 Putative peptidase family CARDB PF07705.11 EXF74384.1 - 0.0076 16.5 0.2 0.0076 16.5 0.2 2.6 2 1 0 2 2 2 1 CARDB Inhibitor_I67 PF11405.8 EXF74384.1 - 7.7 6.9 7.0 0.78 10.1 2.0 1.9 2 0 0 2 2 2 0 Bromelain inhibitor VI Sel1 PF08238.12 EXF74385.1 - 1.5e-10 41.4 7.0 0.0051 17.5 0.1 3.6 3 0 0 3 3 3 3 Sel1 repeat Proteasome PF00227.26 EXF74386.1 - 1.1e-47 162.0 0.1 1.4e-47 161.7 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Pr_beta_C PF12465.8 EXF74386.1 - 3.4e-12 45.5 0.1 3.4e-12 45.5 0.1 1.9 3 0 0 3 3 3 1 Proteasome beta subunits C terminal NUP214 PF16755.5 EXF74387.1 - 1.4e-07 31.1 0.0 4.5e-07 29.4 0.0 1.7 1 1 0 1 1 1 1 Nucleoporin or Nuclear pore complex subunit NUP214=Nup159 ANAPC4_WD40 PF12894.7 EXF74387.1 - 1.9e-05 24.8 0.0 0.00088 19.5 0.1 3.1 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Syntaxin-6_N PF09177.11 EXF74387.1 - 1.2 9.8 3.3 9.3 6.9 2.9 2.4 1 1 1 2 2 2 0 Syntaxin 6, N-terminal Ribosomal_L35Ae PF01247.18 EXF74388.1 - 1.9e-41 140.1 0.6 2.2e-41 139.9 0.6 1.0 1 0 0 1 1 1 1 Ribosomal protein L35Ae RimM PF01782.18 EXF74388.1 - 1.9e-05 24.8 0.1 0.017 15.3 0.0 2.2 2 0 0 2 2 2 2 RimM N-terminal domain G6PD_C PF02781.16 EXF74389.1 - 5e-114 380.4 0.0 8.4e-114 379.7 0.0 1.3 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.22 EXF74389.1 - 1.6e-60 204.8 0.0 2.9e-60 203.9 0.0 1.4 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, NAD binding domain Med14 PF08638.11 EXF74390.1 - 2.6e-65 219.5 0.0 4.8e-65 218.6 0.0 1.5 1 0 0 1 1 1 1 Mediator complex subunit MED14 Amino_oxidase PF01593.24 EXF74391.1 - 1.1e-27 97.5 0.0 1.4e-27 97.1 0.0 1.2 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EXF74391.1 - 1.6e-13 50.7 0.0 4.4e-13 49.3 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EXF74391.1 - 6.6e-09 35.8 0.4 2.6e-07 30.6 0.6 2.4 2 1 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EXF74391.1 - 3.5e-07 29.7 0.2 0.0011 18.2 0.0 3.1 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EXF74391.1 - 0.00015 22.2 0.9 0.26 11.9 0.0 3.7 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EXF74391.1 - 0.00088 19.3 0.0 0.04 13.9 0.0 2.5 2 0 0 2 2 2 1 FAD-NAD(P)-binding Thi4 PF01946.17 EXF74391.1 - 0.0027 17.0 0.0 0.0049 16.1 0.0 1.3 1 0 0 1 1 1 1 Thi4 family Trp_halogenase PF04820.14 EXF74391.1 - 0.0046 15.9 0.1 0.0071 15.3 0.1 1.2 1 0 0 1 1 1 1 Tryptophan halogenase MCRA PF06100.11 EXF74391.1 - 0.0067 15.3 0.0 0.021 13.6 0.0 1.7 2 0 0 2 2 2 1 MCRA family BAR_2 PF10455.9 EXF74391.1 - 0.034 13.3 0.0 0.054 12.6 0.0 1.2 1 0 0 1 1 1 0 Bin/amphiphysin/Rvs domain for vesicular trafficking FAD_binding_2 PF00890.24 EXF74391.1 - 0.062 12.4 1.3 0.081 12.0 0.1 1.8 2 0 0 2 2 2 0 FAD binding domain Mqo PF06039.15 EXF74391.1 - 0.099 11.2 0.0 0.2 10.1 0.0 1.4 2 0 0 2 2 2 0 Malate:quinone oxidoreductase (Mqo) Lycopene_cycl PF05834.12 EXF74391.1 - 0.22 10.5 0.5 0.45 9.5 0.1 1.8 2 0 0 2 2 2 0 Lycopene cyclase protein zf-CCCH_2 PF14608.6 EXF74392.1 - 1.9e-14 53.5 56.6 2.8e-06 27.6 12.6 5.7 5 1 0 5 5 5 4 RNA-binding, Nab2-type zinc finger Nab2 PF11517.8 EXF74392.1 - 0.008 16.5 0.0 0.015 15.6 0.0 1.4 1 0 0 1 1 1 1 Nuclear abundant poly(A) RNA-bind protein 2 (Nab2) Glyco_hydro_20 PF00728.22 EXF74393.1 - 2e-85 287.3 0.0 2.6e-85 286.9 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.6 EXF74393.1 - 8.4e-33 113.9 0.1 1.6e-32 113.0 0.1 1.5 1 0 0 1 1 1 1 beta-acetyl hexosaminidase like Glyco_hydro_20b PF02838.15 EXF74393.1 - 2.6e-09 37.9 0.0 2.3e-07 31.6 0.0 2.3 2 0 0 2 2 2 1 Glycosyl hydrolase family 20, domain 2 p450 PF00067.22 EXF74394.1 - 4.4e-60 203.8 0.0 7.2e-60 203.0 0.0 1.3 1 0 0 1 1 1 1 Cytochrome P450 P22_Tail-4 PF11650.8 EXF74394.1 - 0.15 12.0 0.0 0.27 11.2 0.0 1.3 1 0 0 1 1 1 0 P22 tail accessory factor Aminotran_1_2 PF00155.21 EXF74395.1 - 1.5e-16 60.5 0.0 1.9e-16 60.2 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.7 EXF74395.1 - 4.4e-06 25.7 0.0 1.9e-05 23.7 0.0 1.8 1 1 0 1 1 1 1 Alanine-glyoxylate amino-transferase DegT_DnrJ_EryC1 PF01041.17 EXF74395.1 - 0.00082 18.8 0.0 0.023 14.0 0.0 2.1 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Glyco_hydro_16 PF00722.21 EXF74396.1 - 3.2e-44 150.5 1.5 4.8e-44 149.9 1.5 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 FYVE PF01363.21 EXF74397.1 - 1.8e-20 72.9 0.7 1.8e-20 72.9 0.7 2.9 3 0 0 3 3 3 1 FYVE zinc finger zf-RING_2 PF13639.6 EXF74397.1 - 4.5e-07 30.1 5.2 4.5e-07 30.1 5.2 3.9 4 0 0 4 4 4 1 Ring finger domain zf-C3HC4_2 PF13923.6 EXF74397.1 - 0.00023 20.9 3.9 0.00023 20.9 3.9 3.6 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EXF74397.1 - 0.00034 20.3 4.7 0.00034 20.3 4.7 2.5 3 0 0 3 3 3 1 RING-like zinc finger zf-RING_UBOX PF13445.6 EXF74397.1 - 0.006 16.6 5.5 0.006 16.6 5.5 3.6 3 0 0 3 3 3 1 RING-type zinc-finger Rad50_zn_hook PF04423.14 EXF74397.1 - 0.02 14.7 0.4 0.02 14.7 0.4 1.8 2 0 0 2 2 1 0 Rad50 zinc hook motif zf-C3HC4 PF00097.25 EXF74397.1 - 0.022 14.7 3.6 0.022 14.7 3.6 3.5 4 0 0 4 4 4 0 Zinc finger, C3HC4 type (RING finger) zf-piccolo PF05715.13 EXF74397.1 - 0.49 10.6 16.9 0.22 11.7 5.9 3.0 3 0 0 3 3 3 0 Piccolo Zn-finger FYVE_2 PF02318.16 EXF74397.1 - 1.2 9.4 9.4 0.72 10.1 2.1 2.5 2 0 0 2 2 2 0 FYVE-type zinc finger DZR PF12773.7 EXF74397.1 - 1.8 8.6 7.4 34 4.6 3.7 2.9 2 0 0 2 2 2 0 Double zinc ribbon Elf1 PF05129.13 EXF74397.1 - 4.1 7.5 13.1 0.68 10.0 2.5 3.4 4 0 0 4 4 4 0 Transcription elongation factor Elf1 like p450 PF00067.22 EXF74398.1 - 4.4e-29 101.5 0.0 5.7e-29 101.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Thioesterase PF00975.20 EXF74399.1 - 2.6e-10 40.8 0.0 0.00089 19.4 0.0 3.0 3 0 0 3 3 3 2 Thioesterase domain Abhydrolase_6 PF12697.7 EXF74399.1 - 0.001 19.8 0.4 0.0013 19.4 0.4 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.13 EXF74399.1 - 0.037 13.9 0.0 0.055 13.3 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 EXF74399.1 - 0.043 13.6 0.0 0.085 12.6 0.0 1.4 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase MFS_1 PF07690.16 EXF74401.1 - 6e-17 61.6 47.4 1.2e-15 57.3 42.8 2.5 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EXF74401.1 - 6.7e-11 41.3 14.0 1.3e-10 40.4 14.0 1.6 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) CorA PF01544.18 EXF74402.1 - 2.8e-06 26.9 2.5 2e-05 24.1 0.0 3.0 3 0 0 3 3 3 1 CorA-like Mg2+ transporter protein Rota_NSP4 PF01452.16 EXF74402.1 - 0.026 14.2 0.2 0.073 12.7 0.0 1.9 2 0 0 2 2 2 0 Rotavirus non structural protein ADH_zinc_N_2 PF13602.6 EXF74403.1 - 4e-16 60.3 0.1 1.1e-15 58.9 0.1 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 EXF74403.1 - 2.1e-15 56.8 0.1 3.9e-15 56.0 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EXF74403.1 - 3.5e-07 30.1 0.0 1.8e-06 27.8 0.0 2.2 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_N_2 PF16884.5 EXF74403.1 - 7.5e-05 22.6 0.0 0.0002 21.2 0.0 1.7 1 1 0 1 1 1 1 N-terminal domain of oxidoreductase Propeptide_C1 PF08127.13 EXF74403.1 - 0.05 13.5 1.3 0.1 12.5 0.1 2.1 2 0 0 2 2 2 0 Peptidase family C1 propeptide Fungal_trans PF04082.18 EXF74404.1 - 2.5e-09 36.6 0.1 6e-09 35.3 0.1 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain ATP-synt_D PF01813.17 EXF74404.1 - 0.075 12.9 0.0 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 ATP synthase subunit D ANAPC5 PF12862.7 EXF74404.1 - 0.14 12.3 1.2 5.7 7.1 0.3 2.6 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 5 HET PF06985.11 EXF74405.1 - 3.7e-24 85.7 0.3 6.2e-24 85.0 0.3 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) fn3 PF00041.21 EXF74406.1 - 2.8e-14 53.2 4.3 2.2e-05 24.7 0.0 3.4 3 0 0 3 3 3 3 Fibronectin type III domain Lipase_GDSL_2 PF13472.6 EXF74406.1 - 6.1e-11 43.0 0.2 2.7e-09 37.7 0.0 2.7 2 1 0 2 2 2 1 GDSL-like Lipase/Acylhydrolase family DUF4992 PF16383.5 EXF74406.1 - 0.00067 19.2 0.5 0.53 9.8 0.1 2.4 2 0 0 2 2 2 2 Domain of unknown function Lipase_GDSL PF00657.22 EXF74406.1 - 0.0039 17.2 0.0 0.013 15.4 0.0 1.9 2 1 0 2 2 2 1 GDSL-like Lipase/Acylhydrolase ChitinaseA_N PF08329.10 EXF74406.1 - 0.014 15.1 1.3 0.33 10.6 0.2 2.8 2 1 1 3 3 3 0 Chitinase A, N-terminal domain MF_alpha_N PF05436.11 EXF74407.1 - 0.095 12.6 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 Mating factor alpha precursor N-terminus ATP_sub_h PF10775.9 EXF74407.1 - 0.25 11.3 0.3 0.25 11.3 0.3 2.6 2 1 2 4 4 4 0 ATP synthase complex subunit h DUF3328 PF11807.8 EXF74408.1 - 2.5e-50 171.3 0.4 3.3e-50 170.9 0.4 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) DUF2235 PF09994.9 EXF74409.1 - 2.8e-82 276.3 7.4 8.4e-81 271.5 7.4 2.7 1 1 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) Clr5 PF14420.6 EXF74411.1 - 1.2e-15 57.5 0.5 3.3e-15 56.0 0.5 1.8 1 0 0 1 1 1 1 Clr5 domain TPR_19 PF14559.6 EXF74411.1 - 0.098 13.2 0.2 0.24 12.0 0.2 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat AAA_8 PF12780.7 EXF74411.1 - 0.11 11.9 0.0 0.2 11.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region D4 Zn_clus PF00172.18 EXF74412.1 - 1.4e-10 41.1 10.4 2.3e-10 40.4 10.4 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EXF74412.1 - 1.3e-07 31.0 3.1 4e-07 29.3 2.8 1.8 1 1 0 1 1 1 1 Fungal specific transcription factor domain TFIIA PF03153.13 EXF74412.1 - 0.82 9.6 18.5 1.8 8.5 18.5 1.5 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Ribonuclease_T2 PF00445.18 EXF74414.1 - 1.2e-28 100.6 0.0 1.6e-28 100.2 0.0 1.2 1 0 0 1 1 1 1 Ribonuclease T2 family Bac_luciferase PF00296.20 EXF74414.1 - 0.044 13.2 0.0 0.068 12.6 0.0 1.2 1 0 0 1 1 1 0 Luciferase-like monooxygenase WSC PF01822.19 EXF74415.1 - 3.1e-05 24.1 0.9 5.4e-05 23.3 0.9 1.4 1 0 0 1 1 1 1 WSC domain MVL PF12151.8 EXF74415.1 - 0.18 11.7 0.2 0.37 10.7 0.2 1.4 1 0 0 1 1 1 0 Mannan-binding protein Peptidase_C2 PF00648.21 EXF74416.1 - 1.3e-15 57.2 0.0 2e-15 56.6 0.0 1.3 1 0 0 1 1 1 1 Calpain family cysteine protease Peptidase_C1 PF00112.23 EXF74416.1 - 0.1 12.7 0.2 0.16 12.0 0.2 1.3 1 0 0 1 1 1 0 Papain family cysteine protease MFS_1 PF07690.16 EXF74417.1 - 2.9e-22 79.1 39.2 2.9e-22 79.1 39.2 1.6 2 1 0 2 2 2 1 Major Facilitator Superfamily MFS_3 PF05977.13 EXF74417.1 - 0.0025 16.3 1.0 0.0053 15.2 1.0 1.5 1 0 0 1 1 1 1 Transmembrane secretion effector Methyltransf_23 PF13489.6 EXF74418.1 - 3.6e-22 79.0 0.0 1.2e-21 77.3 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF74418.1 - 7e-11 42.7 0.0 2.1e-10 41.2 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF74418.1 - 8e-11 42.0 0.0 1.8e-09 37.5 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF74418.1 - 3.1e-08 34.2 0.0 8.1e-08 32.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF74418.1 - 8.8e-08 32.8 0.0 9.7e-07 29.5 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.18 EXF74418.1 - 0.0016 17.8 0.0 0.0074 15.6 0.0 1.9 2 0 0 2 2 2 1 O-methyltransferase domain Ubie_methyltran PF01209.18 EXF74418.1 - 0.0023 17.3 0.0 0.074 12.4 0.0 2.3 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 EXF74418.1 - 0.012 15.1 0.0 0.024 14.2 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain PrmA PF06325.13 EXF74418.1 - 0.017 14.5 0.0 0.032 13.6 0.0 1.4 1 1 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) FtsJ PF01728.19 EXF74418.1 - 0.024 14.7 0.0 0.041 14.0 0.0 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_4 PF02390.17 EXF74418.1 - 0.029 13.8 0.0 0.062 12.8 0.0 1.5 1 0 0 1 1 1 0 Putative methyltransferase CheR PF01739.18 EXF74418.1 - 0.052 13.0 0.0 0.13 11.7 0.0 1.6 2 0 0 2 2 2 0 CheR methyltransferase, SAM binding domain GPI-anchored PF10342.9 EXF74419.1 - 1.3e-16 61.2 2.0 1.3e-16 61.2 2.0 2.2 2 1 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family DUF1643 PF07799.12 EXF74421.1 - 0.043 14.0 0.0 0.077 13.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1643) Methyltransf_11 PF08241.12 EXF74424.1 - 1.7e-16 60.7 0.1 4e-16 59.4 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF74424.1 - 2.8e-16 60.0 0.1 5.8e-16 59.0 0.0 1.6 2 0 0 2 2 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EXF74424.1 - 9.6e-15 54.5 0.0 3.4e-14 52.7 0.0 1.7 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.6 EXF74424.1 - 7.1e-13 48.6 0.0 1e-12 48.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF74424.1 - 1.7e-09 38.3 0.0 2.7e-09 37.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EXF74424.1 - 1.1e-07 31.9 0.0 1.7e-07 31.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EXF74424.1 - 0.0014 18.2 0.0 0.0025 17.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_8 PF05148.15 EXF74424.1 - 0.0034 17.3 0.0 0.014 15.2 0.0 1.8 2 0 0 2 2 2 1 Hypothetical methyltransferase TehB PF03848.14 EXF74424.1 - 0.034 13.6 0.0 0.057 12.8 0.0 1.3 1 0 0 1 1 1 0 Tellurite resistance protein TehB MetW PF07021.12 EXF74424.1 - 0.053 13.1 0.0 0.23 11.1 0.0 1.9 1 1 0 1 1 1 0 Methionine biosynthesis protein MetW Methyltr_RsmB-F PF01189.17 EXF74424.1 - 0.08 12.6 0.0 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 16S rRNA methyltransferase RsmB/F DASH_Ask1 PF08655.10 EXF74424.1 - 0.15 12.0 0.1 14 5.7 0.0 2.6 2 0 0 2 2 2 0 DASH complex subunit Ask1 RPN7 PF10602.9 EXF74426.1 - 2.1e-42 144.8 0.0 4e-42 143.9 0.0 1.5 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.27 EXF74426.1 - 9.3e-14 51.8 0.0 2.2e-13 50.6 0.0 1.6 1 0 0 1 1 1 1 PCI domain TPR_2 PF07719.17 EXF74426.1 - 0.088 13.0 0.0 3.1 8.2 0.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat Zn_clus PF00172.18 EXF74428.1 - 6.4e-07 29.4 7.5 9.3e-07 28.9 7.5 1.2 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Peptidase_M20 PF01546.28 EXF74429.1 - 5.5e-23 81.7 0.0 5.4e-22 78.5 0.0 2.4 2 1 0 2 2 2 1 Peptidase family M20/M25/M40 WD40 PF00400.32 EXF74429.1 - 7e-14 52.0 0.5 0.24 12.3 0.0 6.9 6 0 0 6 6 6 3 WD domain, G-beta repeat Peptidase_M28 PF04389.17 EXF74429.1 - 0.031 13.9 0.0 0.066 12.9 0.0 1.4 1 0 0 1 1 1 0 Peptidase family M28 M20_dimer PF07687.14 EXF74429.1 - 0.039 13.9 0.0 0.075 13.0 0.0 1.5 1 0 0 1 1 1 0 Peptidase dimerisation domain Invas_SpaK PF03519.14 EXF74429.1 - 0.06 13.4 0.2 0.94 9.6 0.0 2.6 3 0 0 3 3 3 0 Invasion protein B family Nucleoporin_N PF08801.11 EXF74429.1 - 0.11 11.2 0.0 2.2 6.9 0.0 2.4 2 1 0 2 2 2 0 Nup133 N terminal like Nuc_deoxyri_tr2 PF15891.5 EXF74430.1 - 3.9e-37 126.9 0.0 5.1e-37 126.5 0.0 1.1 1 0 0 1 1 1 1 Nucleoside 2-deoxyribosyltransferase like TFIIA PF03153.13 EXF74431.1 - 0.006 16.6 19.1 0.0081 16.2 19.1 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit LUC7 PF03194.15 EXF74432.1 - 2.3e-70 237.1 2.9 2.9e-70 236.8 2.9 1.0 1 0 0 1 1 1 1 LUC7 N_terminus DUF1241 PF06840.11 EXF74432.1 - 0.045 13.4 0.1 0.077 12.6 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1241) GRP PF07172.11 EXF74432.1 - 0.063 14.0 7.4 0.16 12.7 7.4 1.7 1 0 0 1 1 1 0 Glycine rich protein family MCPsignal PF00015.21 EXF74432.1 - 0.082 12.7 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Sec8_exocyst PF04048.14 EXF74432.1 - 0.13 12.2 0.4 0.26 11.2 0.1 1.7 1 1 1 2 2 2 0 Sec8 exocyst complex component specific domain Gpi16 PF04113.14 EXF74433.1 - 9.9e-247 819.9 0.0 1.2e-246 819.6 0.0 1.0 1 0 0 1 1 1 1 Gpi16 subunit, GPI transamidase component Peptidase_S8 PF00082.22 EXF74434.1 - 6.5e-45 153.6 0.9 9.9e-45 153.1 0.9 1.2 1 0 0 1 1 1 1 Subtilase family fn3_5 PF06280.12 EXF74434.1 - 2.7e-07 31.3 0.0 4.7e-07 30.5 0.0 1.4 1 0 0 1 1 1 1 Fn3-like domain MFS_1 PF07690.16 EXF74435.1 - 6.3e-21 74.7 23.3 6.3e-21 74.7 23.3 2.2 1 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF74435.1 - 0.0004 19.4 14.1 0.0004 19.4 14.1 2.8 2 2 0 2 2 2 1 Sugar (and other) transporter DUF3533 PF12051.8 EXF74436.1 - 1.1e-64 218.8 14.3 1.2e-64 218.6 14.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3533) Pectinesterase PF01095.19 EXF74437.1 - 2.3e-51 174.3 8.3 2.8e-51 174.0 8.3 1.1 1 0 0 1 1 1 1 Pectinesterase DUF3762 PF12591.8 EXF74437.1 - 0.16 12.3 1.3 0.28 11.4 0.3 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3762) DUF3306 PF11748.8 EXF74439.1 - 0.53 11.2 7.0 1.1 10.2 7.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3306) Glyco_hydro_61 PF03443.14 EXF74440.1 - 3.6e-66 223.0 0.2 3.6e-66 223.0 0.2 1.4 2 0 0 2 2 2 1 Glycosyl hydrolase family 61 Med3 PF11593.8 EXF74440.1 - 3.4 6.8 19.2 4.7 6.3 19.2 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Herpes_capsid PF06112.11 EXF74440.1 - 7.6 6.6 24.8 15 5.6 24.8 1.5 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein MFS_1 PF07690.16 EXF74441.1 - 4.6e-34 117.9 44.9 1.3e-29 103.2 30.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily PUCC PF03209.15 EXF74441.1 - 0.00064 18.8 11.5 0.044 12.8 1.1 3.2 2 1 1 3 3 3 3 PUCC protein Zn_clus PF00172.18 EXF74442.1 - 2.6e-08 33.9 11.6 2.6e-08 33.9 11.6 2.0 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EXF74443.1 - 5.6e-12 45.3 0.8 1.3e-11 44.1 0.8 1.6 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF74443.1 - 0.0012 19.0 7.2 0.0023 18.0 7.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Sugar_tr PF00083.24 EXF74444.1 - 1.3e-82 278.1 8.9 1.5e-82 277.9 8.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF74444.1 - 9.5e-17 60.9 11.1 9.5e-17 60.9 11.1 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 EXF74444.1 - 0.028 12.8 4.0 0.016 13.7 1.1 1.8 2 0 0 2 2 2 0 Fungal trichothecene efflux pump (TRI12) Zn_clus PF00172.18 EXF74445.1 - 7e-13 48.5 20.7 3e-08 33.6 11.7 2.5 2 0 0 2 2 2 2 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EXF74445.1 - 1.9e-11 43.5 1.2 3.7e-11 42.6 1.2 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Seryl_tRNA_N PF02403.22 EXF74445.1 - 0.019 15.2 0.1 11 6.4 0.0 2.6 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Cu_amine_oxid PF01179.20 EXF74446.1 - 5.8e-130 433.9 9.4 7e-130 433.6 9.4 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain DUF1965 PF09248.10 EXF74446.1 - 7.6e-31 105.7 1.3 2.2e-30 104.2 1.3 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF1965) Cu_amine_oxidN2 PF02727.16 EXF74446.1 - 3.7e-06 27.1 0.0 9.8e-06 25.7 0.0 1.6 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain Pheromone PF08015.11 EXF74447.1 - 0.038 15.0 2.0 0.087 13.9 2.0 1.7 1 0 0 1 1 1 0 Fungal mating-type pheromone CDH-cyt PF16010.5 EXF74448.1 - 9.8e-69 230.7 6.1 2.2e-68 229.5 6.1 1.6 1 0 0 1 1 1 1 Cytochrome domain of cellobiose dehydrogenase GMC_oxred_N PF00732.19 EXF74448.1 - 2.7e-24 86.1 0.0 5.8e-24 85.0 0.0 1.6 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EXF74448.1 - 1.1e-22 81.1 0.2 2e-22 80.3 0.2 1.5 1 0 0 1 1 1 1 GMC oxidoreductase CBM_1 PF00734.18 EXF74448.1 - 4.1e-10 39.4 7.5 2.1e-09 37.2 7.5 2.3 1 0 0 1 1 1 1 Fungal cellulose binding domain FAD_binding_2 PF00890.24 EXF74448.1 - 9.4e-10 38.1 0.6 0.00016 20.9 0.1 2.4 3 0 0 3 3 3 2 FAD binding domain NAD_binding_8 PF13450.6 EXF74448.1 - 0.00011 22.3 0.1 0.00042 20.5 0.0 2.1 2 0 0 2 2 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 EXF74448.1 - 0.0012 17.7 0.3 0.0021 16.8 0.0 1.5 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox_2 PF07992.14 EXF74448.1 - 0.0018 17.6 0.0 0.0041 16.4 0.0 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EXF74448.1 - 0.0057 15.7 0.5 0.011 14.8 0.1 1.7 2 0 0 2 2 2 1 Lycopene cyclase protein Pyr_redox_3 PF13738.6 EXF74448.1 - 0.014 14.6 0.2 0.048 12.9 0.5 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EXF74448.1 - 0.021 14.1 0.0 0.034 13.4 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain Pyr_redox PF00070.27 EXF74448.1 - 0.021 15.4 0.0 0.65 10.6 0.0 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EXF74448.1 - 0.024 14.0 0.0 0.3 10.4 0.0 2.2 2 0 0 2 2 2 0 FAD dependent oxidoreductase Thi4 PF01946.17 EXF74448.1 - 0.24 10.6 0.3 0.8 8.9 0.3 1.8 2 0 0 2 2 2 0 Thi4 family Glyco_hydro_43 PF04616.14 EXF74449.1 - 0.00068 19.0 0.4 0.0011 18.4 0.4 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 Glyco_hydro_32N PF00251.20 EXF74449.1 - 0.0056 16.3 0.1 0.012 15.2 0.1 1.6 1 1 0 1 1 1 1 Glycosyl hydrolases family 32 N-terminal domain DUF2456 PF10445.9 EXF74452.1 - 6.3e-13 48.6 0.5 6.3e-13 48.6 0.5 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF2456) Ligase_CoA PF00549.19 EXF74454.1 - 3.8e-17 62.5 0.3 7.3e-17 61.6 0.3 1.5 1 0 0 1 1 1 1 CoA-ligase CoA_binding PF02629.19 EXF74454.1 - 1.7e-16 60.7 12.8 7.4e-12 45.8 0.2 3.1 3 1 1 4 4 4 2 CoA binding domain Succ_CoA_lig PF13607.6 EXF74454.1 - 1.9e-09 37.4 0.0 3.6e-09 36.5 0.0 1.4 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.6 EXF74454.1 - 0.048 14.2 0.7 0.14 12.7 0.0 2.2 3 1 0 3 3 3 0 CoA binding domain Fungal_trans PF04082.18 EXF74455.1 - 3.5e-22 78.7 0.3 5.6e-22 78.0 0.3 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF74455.1 - 2.8e-05 24.1 12.3 4.6e-05 23.5 12.3 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pkinase PF00069.25 EXF74456.1 - 1.7e-13 50.5 0.0 1.5e-10 40.9 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EXF74456.1 - 2.3e-05 23.8 0.0 4.8e-05 22.8 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Sep15_SelM PF08806.11 EXF74456.1 - 0.0001 22.4 0.3 0.00024 21.2 0.3 1.6 1 0 0 1 1 1 1 Sep15/SelM redox domain HTH_55 PF18622.1 EXF74456.1 - 0.18 12.1 0.0 0.47 10.8 0.0 1.6 1 0 0 1 1 1 0 RctB helix turn helix domain Pkinase PF00069.25 EXF74457.1 - 8e-23 81.1 0.0 1.3e-22 80.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF74457.1 - 2.5e-16 59.8 0.0 3.5e-16 59.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EXF74457.1 - 0.015 14.7 0.4 0.27 10.6 0.0 2.6 3 1 1 4 4 4 0 Lipopolysaccharide kinase (Kdo/WaaP) family Acetyltransf_16 PF05301.11 EXF74457.1 - 0.12 12.1 0.1 1.7 8.4 0.0 2.1 2 0 0 2 2 2 0 GNAT acetyltransferase, Mec-17 Gln-synt_C PF00120.24 EXF74458.1 - 1.6e-75 254.3 0.0 2.3e-75 253.7 0.0 1.3 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain Amidohydro_2 PF04909.14 EXF74458.1 - 2.9e-15 56.8 0.0 5.9e-15 55.8 0.0 1.5 1 0 0 1 1 1 1 Amidohydrolase DSBA PF01323.20 EXF74459.1 - 1.2e-12 48.0 0.1 1.3e-12 47.9 0.1 1.0 1 0 0 1 1 1 1 DSBA-like thioredoxin domain Prion PF00377.18 EXF74459.1 - 0.081 12.8 0.2 0.12 12.2 0.2 1.3 1 0 0 1 1 1 0 Prion/Doppel alpha-helical domain Amidohydro_3 PF07969.11 EXF74460.1 - 5.9e-71 240.3 0.2 6.7e-71 240.2 0.2 1.0 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_1 PF01979.20 EXF74460.1 - 6.3e-15 55.3 0.0 3.1e-11 43.2 0.0 2.3 2 0 0 2 2 2 2 Amidohydrolase family Aldedh PF00171.22 EXF74461.1 - 4.4e-179 595.8 1.5 5.2e-179 595.6 1.5 1.1 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DJ-1_PfpI PF01965.24 EXF74461.1 - 2.5e-15 56.7 0.0 6.7e-15 55.3 0.0 1.7 2 0 0 2 2 2 1 DJ-1/PfpI family Wtap PF17098.5 EXF74461.1 - 0.019 14.9 0.0 0.034 14.1 0.0 1.3 1 0 0 1 1 1 0 WTAP/Mum2p family NAD_binding_10 PF13460.6 EXF74462.1 - 4.2e-13 49.6 0.6 8.5e-13 48.6 0.6 1.5 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EXF74462.1 - 2e-12 47.1 0.1 9.2e-08 31.8 0.2 2.2 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family NmrA PF05368.13 EXF74462.1 - 6.2e-11 42.3 0.3 1.4e-10 41.1 0.2 1.6 2 0 0 2 2 2 1 NmrA-like family Semialdhyde_dh PF01118.24 EXF74462.1 - 4.4e-06 27.1 0.1 8.3e-06 26.2 0.1 1.6 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain GDP_Man_Dehyd PF16363.5 EXF74462.1 - 9e-06 25.3 0.2 0.00014 21.4 0.2 2.1 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 EXF74462.1 - 1.6e-05 24.0 0.1 3.6e-05 22.9 0.1 1.5 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 EXF74462.1 - 2.1e-05 23.9 0.4 0.00038 19.7 0.4 2.2 1 1 0 1 1 1 1 Male sterility protein Sacchrp_dh_NADP PF03435.18 EXF74462.1 - 0.0012 19.2 0.4 0.0026 18.0 0.1 1.7 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain RmlD_sub_bind PF04321.17 EXF74462.1 - 0.0019 17.4 0.1 0.044 12.9 0.1 2.1 2 0 0 2 2 2 1 RmlD substrate binding domain DXP_reductoisom PF02670.16 EXF74462.1 - 0.036 14.8 0.7 0.13 13.0 0.1 2.1 2 1 1 3 3 3 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase Polysacc_synt_2 PF02719.15 EXF74462.1 - 0.062 12.4 0.1 0.11 11.6 0.1 1.4 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Aminotran_3 PF00202.21 EXF74463.1 - 8.4e-94 314.5 0.0 1e-93 314.2 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Fungal_trans_2 PF11951.8 EXF74464.1 - 4.2e-41 141.0 8.9 6e-41 140.5 8.9 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF74464.1 - 1.3e-09 38.0 4.5 2.2e-09 37.3 4.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DHDPS PF00701.22 EXF74465.1 - 2.2e-57 194.0 0.0 2.4e-57 193.8 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family FMN_dh PF01070.18 EXF74466.1 - 2.1e-113 378.9 0.0 2.5e-113 378.7 0.0 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase IMPDH PF00478.25 EXF74466.1 - 1.4e-06 27.5 0.3 6.4e-06 25.4 0.1 2.0 2 0 0 2 2 2 1 IMP dehydrogenase / GMP reductase domain Glu_synthase PF01645.17 EXF74466.1 - 0.00059 19.1 0.2 0.002 17.3 0.0 1.8 2 1 0 3 3 3 1 Conserved region in glutamate synthase His_biosynth PF00977.21 EXF74466.1 - 0.0024 17.4 0.1 0.016 14.7 0.0 2.0 1 1 0 2 2 2 1 Histidine biosynthesis protein ThiG PF05690.14 EXF74466.1 - 0.02 14.2 1.6 0.42 9.9 0.0 2.8 3 1 0 4 4 4 0 Thiazole biosynthesis protein ThiG NMO PF03060.15 EXF74466.1 - 0.066 12.6 0.3 0.098 12.0 0.3 1.2 1 0 0 1 1 1 0 Nitronate monooxygenase DHO_dh PF01180.21 EXF74466.1 - 0.069 12.4 0.1 0.14 11.4 0.1 1.4 1 1 0 1 1 1 0 Dihydroorotate dehydrogenase Aldedh PF00171.22 EXF74467.1 - 1.5e-135 452.3 0.1 1.7e-135 452.1 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 EXF74467.1 - 0.1 11.6 0.0 0.16 11.0 0.0 1.2 1 0 0 1 1 1 0 Acyl-CoA reductase (LuxC) AA_permease PF00324.21 EXF74468.1 - 4.1e-106 355.4 40.3 4.6e-106 355.3 40.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EXF74468.1 - 8.3e-27 94.1 45.1 1e-26 93.8 45.1 1.0 1 0 0 1 1 1 1 Amino acid permease DUF2157 PF09925.9 EXF74468.1 - 0.039 13.8 0.0 0.039 13.8 0.0 3.3 4 0 0 4 4 4 0 Predicted membrane protein (DUF2157) HTH_23 PF13384.6 EXF74469.1 - 0.00021 21.0 0.0 0.00063 19.5 0.0 1.8 2 0 0 2 2 2 1 Homeodomain-like domain Sigma70_r4 PF04545.16 EXF74469.1 - 0.001 18.5 0.0 0.0015 18.0 0.0 1.2 1 0 0 1 1 1 1 Sigma-70, region 4 Sigma70_r4_2 PF08281.12 EXF74469.1 - 0.0018 17.9 0.0 0.0037 16.9 0.0 1.5 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_29 PF13551.6 EXF74469.1 - 0.0019 18.2 0.1 0.012 15.6 0.1 2.1 2 1 0 2 2 2 1 Winged helix-turn helix Abhydrolase_1 PF00561.20 EXF74470.1 - 6.7e-21 75.1 0.0 8.2e-21 74.8 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EXF74470.1 - 2.3e-18 67.6 0.1 3e-18 67.2 0.1 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EXF74470.1 - 5.7e-08 32.3 0.1 8.4e-07 28.5 0.1 2.0 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Chlorophyllase2 PF12740.7 EXF74470.1 - 4.4e-05 22.5 0.1 0.0011 18.0 0.0 2.2 2 1 0 2 2 2 1 Chlorophyllase enzyme Chlorophyllase PF07224.11 EXF74470.1 - 0.0001 21.4 0.0 0.00029 19.9 0.0 1.7 2 0 0 2 2 2 1 Chlorophyllase Ndr PF03096.14 EXF74470.1 - 0.0023 16.7 0.0 0.0036 16.1 0.0 1.2 1 0 0 1 1 1 1 Ndr family AXE1 PF05448.12 EXF74470.1 - 0.0031 16.2 0.0 0.012 14.3 0.0 1.8 2 0 0 2 2 2 1 Acetyl xylan esterase (AXE1) DLH PF01738.18 EXF74470.1 - 0.0073 15.9 0.0 0.4 10.2 0.0 2.1 2 0 0 2 2 2 1 Dienelactone hydrolase family p450 PF00067.22 EXF74471.1 - 1.4e-71 241.7 0.0 1.9e-71 241.2 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 DUF3989 PF13150.6 EXF74471.1 - 0.071 12.9 0.3 0.34 10.7 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3989) AJAP1_PANP_C PF15298.6 EXF74472.1 - 1.1 9.5 3.9 0.27 11.4 0.5 1.6 2 0 0 2 2 2 0 AJAP1/PANP C-terminus DnaJ PF00226.31 EXF74473.1 - 1.1e-20 73.5 1.6 1.6e-20 72.9 1.6 1.3 1 0 0 1 1 1 1 DnaJ domain Porin_3 PF01459.22 EXF74474.1 - 5.5e-64 216.2 12.5 4e-53 180.6 6.0 2.0 2 0 0 2 2 2 2 Eukaryotic porin OMP_b-brl PF13505.6 EXF74474.1 - 1.5 8.9 16.3 0.73 9.9 8.6 2.5 1 1 0 2 2 2 0 Outer membrane protein beta-barrel domain Asn_synthase PF00733.21 EXF74475.1 - 7.5e-94 315.3 0.0 6e-55 187.3 0.0 2.1 1 1 1 2 2 2 2 Asparagine synthase GATase_7 PF13537.6 EXF74475.1 - 3.9e-40 136.6 0.0 6.2e-40 135.9 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 EXF74475.1 - 2.4e-30 105.5 0.0 4.4e-30 104.6 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain DUF3700 PF12481.8 EXF74475.1 - 1e-08 34.9 0.0 1.9e-08 34.0 0.0 1.3 1 0 0 1 1 1 1 Aluminium induced protein NAD_synthase PF02540.17 EXF74475.1 - 0.0011 18.2 0.0 0.0034 16.5 0.0 1.8 1 1 0 1 1 1 1 NAD synthase UQ_con PF00179.26 EXF74476.1 - 7.5e-50 168.2 0.1 8.5e-50 168.1 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EXF74476.1 - 6.1e-05 22.7 0.0 7e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 EXF74476.1 - 0.0092 16.3 2.5 0.02 15.2 2.5 1.8 1 1 0 1 1 1 1 RWD domain Pex19 PF04614.12 EXF74477.1 - 1.9e-75 253.8 17.1 1.9e-75 253.8 17.1 1.9 1 1 1 2 2 2 1 Pex19 protein family Exo70 PF03081.15 EXF74477.1 - 0.037 13.1 0.1 0.085 11.9 0.1 1.6 1 1 0 1 1 1 0 Exo70 exocyst complex subunit ABC_tran_Xtn PF12848.7 EXF74477.1 - 0.25 11.4 6.1 0.36 10.9 1.0 2.7 2 0 0 2 2 2 0 ABC transporter KIX_2 PF16987.5 EXF74477.1 - 0.37 10.8 5.5 0.16 12.0 0.9 2.5 2 0 0 2 2 2 0 KIX domain GET2 PF08690.10 EXF74477.1 - 1.2 8.7 22.8 0.02 14.6 6.6 2.4 1 1 1 2 2 2 0 GET complex subunit GET2 CRR7 PF12095.8 EXF74477.1 - 1.3 9.5 5.3 0.91 10.0 0.4 2.6 2 0 0 2 2 2 0 Protein CHLORORESPIRATORY REDUCTION 7 ARL2_Bind_BART PF11527.8 EXF74477.1 - 1.7 8.8 5.1 1.2 9.3 0.2 2.6 2 1 0 2 2 2 0 The ARF-like 2 binding protein BART CHASE3 PF05227.13 EXF74477.1 - 6.4 6.7 10.0 3.7 7.5 0.1 3.0 3 0 0 3 3 3 0 CHASE3 domain ABC1 PF03109.16 EXF74479.1 - 7.3e-32 110.0 0.0 1.3e-31 109.2 0.0 1.5 1 0 0 1 1 1 1 ABC1 family Con-6 PF10346.9 EXF74480.1 - 2e-31 107.7 8.1 3.1e-17 62.3 0.2 2.1 2 0 0 2 2 2 2 Conidiation protein 6 DUF1542 PF07564.11 EXF74480.1 - 0.0089 16.1 1.3 2.1 8.5 0.2 2.2 2 0 0 2 2 2 2 Domain of Unknown Function (DUF1542) Glyco_transf_8C PF08437.10 EXF74480.1 - 0.25 11.5 0.6 23 5.2 0.1 2.1 2 0 0 2 2 2 0 Glycosyl transferase family 8 C-terminal TMEM234 PF10639.9 EXF74481.1 - 7.2e-36 122.7 0.2 9.5e-36 122.4 0.2 1.2 1 0 0 1 1 1 1 Putative transmembrane family 234 EamA PF00892.20 EXF74481.1 - 3e-05 24.2 3.2 0.035 14.3 3.4 2.2 2 0 0 2 2 2 2 EamA-like transporter family PetM PF08041.11 EXF74481.1 - 8.8 6.0 8.2 1.4 8.6 2.6 2.5 2 0 0 2 2 2 0 PetM family of cytochrome b6f complex subunit 7 DUF2011 PF09428.10 EXF74482.1 - 0.042 14.1 0.0 0.98 9.7 0.0 2.1 1 1 0 2 2 2 0 Fungal protein of unknown function (DUF2011) Proteasome PF00227.26 EXF74483.1 - 4.6e-46 156.7 0.0 6.5e-46 156.2 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EXF74483.1 - 1e-13 50.7 0.3 2.1e-13 49.6 0.3 1.6 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature DUF2373 PF10180.9 EXF74484.1 - 3.8e-23 81.1 0.1 6.5e-23 80.4 0.1 1.4 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2373) MalM PF07148.12 EXF74484.1 - 0.3 10.8 2.0 0.62 9.8 2.0 1.4 1 0 0 1 1 1 0 Maltose operon periplasmic protein precursor (MalM) FancD2 PF14631.6 EXF74484.1 - 8.2 3.7 10.9 16 2.8 10.9 1.5 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease PhyH PF05721.13 EXF74485.1 - 4.6e-62 210.0 0.0 5.9e-62 209.7 0.0 1.1 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) 2OG-FeII_Oxy_5 PF13759.6 EXF74485.1 - 0.017 15.5 0.0 0.033 14.6 0.0 1.5 1 0 0 1 1 1 0 Putative 2OG-Fe(II) oxygenase Claudin_2 PF13903.6 EXF74486.1 - 0.011 15.4 7.7 0.15 11.8 7.7 2.1 1 1 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction SIS PF01380.22 EXF74487.1 - 1.6e-10 40.9 0.4 5.8e-10 39.1 0.4 1.8 1 1 0 1 1 1 1 SIS domain C2 PF00168.30 EXF74488.1 - 3e-16 59.6 0.0 7e-16 58.4 0.0 1.7 2 0 0 2 2 2 1 C2 domain Peptidase_M24 PF00557.24 EXF74489.1 - 5.7e-37 127.4 0.0 7.3e-37 127.1 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 YL1 PF05764.13 EXF74489.1 - 0.012 15.7 1.9 0.017 15.3 1.9 1.1 1 0 0 1 1 1 0 YL1 nuclear protein Med3 PF11593.8 EXF74489.1 - 0.031 13.5 6.1 0.059 12.6 6.1 1.3 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal TSGP1 PF07771.11 EXF74489.1 - 0.53 10.4 4.7 1.1 9.5 4.7 1.5 1 0 0 1 1 1 0 Tick salivary peptide group 1 Ank_2 PF12796.7 EXF74490.1 - 3e-24 85.4 2.0 5.8e-08 33.2 0.1 5.0 4 1 0 4 4 4 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EXF74490.1 - 3.6e-15 54.6 3.9 0.28 11.9 0.0 8.2 7 1 1 8 8 7 3 Ankyrin repeat Ank_4 PF13637.6 EXF74490.1 - 6.3e-14 52.2 1.1 2.8e-05 24.6 0.0 5.7 4 2 1 5 5 5 3 Ankyrin repeats (many copies) Ank PF00023.30 EXF74490.1 - 1.7e-11 44.0 4.8 0.049 14.1 0.1 6.7 6 0 0 6 6 6 3 Ankyrin repeat NACHT PF05729.12 EXF74490.1 - 4.1e-11 43.1 0.0 9.3e-11 41.9 0.0 1.6 1 0 0 1 1 1 1 NACHT domain Ank_5 PF13857.6 EXF74490.1 - 1.3e-05 25.3 1.1 0.11 12.9 0.0 4.9 2 2 3 5 5 5 1 Ankyrin repeats (many copies) RNA_helicase PF00910.22 EXF74490.1 - 0.0066 16.8 1.1 0.35 11.3 0.0 3.0 3 0 0 3 3 2 1 RNA helicase NB-ARC PF00931.22 EXF74490.1 - 0.0081 15.4 0.0 0.15 11.2 0.0 2.3 2 0 0 2 2 2 1 NB-ARC domain AAA PF00004.29 EXF74490.1 - 0.011 16.1 0.0 0.043 14.2 0.0 2.0 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EXF74490.1 - 0.025 14.9 0.0 0.12 12.8 0.0 2.2 1 0 0 1 1 1 0 AAA ATPase domain RTTN_N PF14726.6 EXF74490.1 - 0.047 14.5 0.2 0.33 11.8 0.1 2.5 2 0 0 2 2 2 0 Rotatin, an armadillo repeat protein, centriole functioning ATPase PF06745.13 EXF74490.1 - 0.12 11.7 0.0 0.22 10.8 0.0 1.4 1 0 0 1 1 1 0 KaiC RRM_1 PF00076.22 EXF74491.1 - 5.7e-19 67.7 0.1 2.3e-11 43.4 0.0 4.0 3 1 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EXF74491.1 - 0.0083 16.2 0.1 0.21 11.7 0.1 2.5 2 0 0 2 2 2 1 RNA recognition motif Nup35_RRM_2 PF14605.6 EXF74491.1 - 0.053 13.5 0.0 0.15 12.1 0.0 1.7 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif Cut8 PF08559.10 EXF74492.1 - 2.4e-76 256.5 0.0 2.9e-76 256.2 0.0 1.0 1 0 0 1 1 1 1 Cut8, nuclear proteasome tether protein AP_endonuc_2 PF01261.24 EXF74492.1 - 0.037 13.5 0.1 0.063 12.7 0.1 1.3 1 0 0 1 1 1 0 Xylose isomerase-like TIM barrel Rad52_Rad22 PF04098.15 EXF74493.1 - 1.8e-60 203.3 0.0 2.4e-60 202.9 0.0 1.2 1 0 0 1 1 1 1 Rad52/22 family double-strand break repair protein Rad21_Rec8 PF04824.16 EXF74496.1 - 0.096 12.0 0.0 0.17 11.2 0.0 1.4 1 0 0 1 1 1 0 Conserved region of Rad21 / Rec8 like protein UTP15_C PF09384.10 EXF74497.1 - 1.5e-46 157.7 0.0 2.5e-46 157.0 0.0 1.3 1 0 0 1 1 1 1 UTP15 C terminal WD40 PF00400.32 EXF74497.1 - 1.4e-18 66.9 5.7 2e-05 25.2 0.1 5.0 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EXF74497.1 - 1.1e-06 28.8 0.0 0.18 12.2 0.0 4.3 3 1 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain RAB3GAP2_N PF14655.6 EXF74497.1 - 0.04 13.2 0.0 0.77 9.0 0.0 2.1 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Pinin_SDK_memA PF04696.13 EXF74497.1 - 0.049 13.7 3.1 0.079 13.0 3.1 1.3 1 0 0 1 1 1 0 pinin/SDK/memA/ protein conserved region WD40_3 PF15911.5 EXF74497.1 - 0.079 13.0 0.0 11 6.1 0.0 2.8 3 0 0 3 3 3 0 WD domain, G-beta repeat Gln-synt_C PF00120.24 EXF74498.1 - 7.8e-15 54.7 0.0 1.6e-10 40.6 0.0 2.1 2 0 0 2 2 2 2 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.19 EXF74498.1 - 9.5e-14 50.9 0.0 2e-13 49.9 0.0 1.5 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain Attractin PF08037.11 EXF74501.1 - 0.35 10.9 4.8 1.1 9.3 4.8 1.9 1 0 0 1 1 1 0 Attractin family zf-piccolo PF05715.13 EXF74502.1 - 5 7.4 12.6 0.94 9.7 6.7 2.4 2 0 0 2 2 2 0 Piccolo Zn-finger MRP-L20 PF12824.7 EXF74503.1 - 6.1e-54 182.6 1.2 7.3e-54 182.3 1.2 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein subunit L20 Neugrin PF06413.11 EXF74503.1 - 0.0018 18.3 0.0 0.0034 17.4 0.0 1.5 1 0 0 1 1 1 1 Neugrin HTH_11 PF08279.12 EXF74503.1 - 0.095 12.7 0.0 0.34 10.9 0.0 1.9 2 0 0 2 2 2 0 HTH domain DUF3484 PF11983.8 EXF74504.1 - 0.21 12.7 0.1 0.21 12.7 0.1 2.5 2 1 0 2 2 2 0 Membrane-attachment and polymerisation-promoting switch Ndc1_Nup PF09531.10 EXF74504.1 - 7.2 5.2 5.7 9.5 4.8 5.7 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup OB_NTP_bind PF07717.16 EXF74505.1 - 7.4e-21 74.3 0.0 1.8e-20 73.1 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.23 EXF74505.1 - 4.6e-19 68.7 0.1 4.6e-19 68.7 0.1 3.6 3 1 0 3 3 3 1 Helicase associated domain (HA2) Helicase_C PF00271.31 EXF74505.1 - 1.3e-14 54.5 0.2 5.1e-14 52.6 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 EXF74505.1 - 3.2e-05 23.8 0.0 8.2e-05 22.4 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EXF74505.1 - 6.7e-05 23.2 2.2 9.6e-05 22.7 0.0 2.3 3 0 0 3 3 3 1 AAA domain T2SSE PF00437.20 EXF74505.1 - 0.002 17.3 0.0 0.0047 16.0 0.0 1.6 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_30 PF13604.6 EXF74505.1 - 0.0054 16.5 0.0 0.0054 16.5 0.0 1.8 2 0 0 2 2 2 1 AAA domain SRP54 PF00448.22 EXF74505.1 - 0.012 15.3 0.2 0.031 13.9 0.2 1.7 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_14 PF13173.6 EXF74505.1 - 0.2 11.7 2.4 2.9 7.9 0.1 3.2 2 1 0 2 2 2 0 AAA domain ABC_tran PF00005.27 EXF74505.1 - 0.41 11.2 0.0 0.41 11.2 0.0 2.3 3 1 0 3 3 3 0 ABC transporter DnaJ PF00226.31 EXF74506.1 - 5.8e-26 90.4 3.1 9.3e-26 89.7 3.1 1.3 1 0 0 1 1 1 1 DnaJ domain DnaJ_C PF01556.18 EXF74506.1 - 2.4e-24 86.1 0.0 3.6e-24 85.5 0.0 1.3 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.19 EXF74506.1 - 6.7e-13 48.8 18.0 1.2e-12 48.0 18.0 1.4 1 0 0 1 1 1 1 DnaJ central domain HypA PF01155.19 EXF74506.1 - 0.0013 18.7 7.1 0.22 11.6 1.2 2.3 2 0 0 2 2 2 2 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Anti-TRAP PF15777.5 EXF74506.1 - 0.21 11.6 8.6 2.8 8.0 0.6 2.4 2 0 0 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein TackOD1 PF18551.1 EXF74506.1 - 2.1 8.0 5.3 2.6 7.7 0.5 2.2 1 1 1 2 2 2 0 Thaumarchaeal output domain 1 DZR PF12773.7 EXF74506.1 - 8 6.6 8.2 22 5.2 8.2 1.7 1 1 0 1 1 1 0 Double zinc ribbon DUF3824 PF12868.7 EXF74507.1 - 2.1e-06 28.5 32.7 1.1e-05 26.1 10.2 11.5 4 3 6 11 11 11 5 Domain of unknwon function (DUF3824) Phage_holin_3_3 PF16083.5 EXF74507.1 - 0.57 10.3 2.6 7.8 6.7 0.7 3.3 2 1 1 3 3 3 0 LydA holin phage, holin superfamily III MFS_1 PF07690.16 EXF74508.1 - 4.2e-42 144.4 42.5 4.2e-42 144.4 42.5 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily GPI-anchored PF10342.9 EXF74509.1 - 1.2e-05 25.9 1.0 1.2e-05 25.9 1.0 1.7 2 0 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family DUF4690 PF15756.5 EXF74509.1 - 8.8e-05 23.0 0.7 0.00018 22.0 0.7 1.5 1 0 0 1 1 1 1 Small Novel Rich in Cartilage Podoplanin PF05808.11 EXF74509.1 - 0.0057 16.8 0.2 0.0095 16.1 0.2 1.3 1 0 0 1 1 1 1 Podoplanin Sacchrp_dh_C PF16653.5 EXF74510.1 - 6.6e-80 269.0 0.0 1.8e-79 267.6 0.0 1.7 1 1 0 1 1 1 1 Saccharopine dehydrogenase C-terminal domain Sacchrp_dh_NADP PF03435.18 EXF74510.1 - 8.4e-22 77.8 0.0 1.2e-21 77.3 0.0 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 EXF74510.1 - 1.2e-07 31.9 0.0 1.9e-07 31.3 0.0 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_10 PF13460.6 EXF74510.1 - 0.034 14.1 0.0 0.05 13.5 0.0 1.2 1 0 0 1 1 1 0 NAD(P)H-binding F420_oxidored PF03807.17 EXF74510.1 - 0.046 14.3 0.0 0.084 13.5 0.0 1.4 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent TatD_DNase PF01026.21 EXF74511.1 - 5.4e-39 134.1 0.0 8.7e-39 133.4 0.0 1.3 1 1 0 1 1 1 1 TatD related DNase HAD_2 PF13419.6 EXF74512.1 - 2.6e-09 37.4 0.0 1.2e-08 35.2 0.0 1.9 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EXF74512.1 - 0.0013 19.0 0.0 0.0058 16.9 0.0 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Ten1 PF12658.7 EXF74513.1 - 2.5e-30 104.9 0.0 3e-30 104.7 0.0 1.1 1 0 0 1 1 1 1 Telomere capping, CST complex subunit Ten1_2 PF15490.6 EXF74513.1 - 0.00034 20.3 0.0 0.00035 20.3 0.0 1.1 1 0 0 1 1 1 1 Telomere-capping, CST complex subunit Snf7 PF03357.21 EXF74514.1 - 1e-29 103.3 18.6 1e-29 103.3 18.6 2.0 1 1 1 2 2 2 2 Snf7 Allexi_40kDa PF05549.11 EXF74514.1 - 0.96 8.9 6.6 1.4 8.4 6.5 1.4 1 1 0 1 1 1 0 Allexivirus 40kDa protein DUF3138 PF11336.8 EXF74514.1 - 3.3 6.2 10.7 0.19 10.3 3.5 2.2 1 1 2 3 3 3 0 Protein of unknown function (DUF3138) DUF4587 PF15248.6 EXF74515.1 - 1.2 10.0 6.2 1.5e+03 0.1 6.2 7.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4587) Cu-oxidase_3 PF07732.15 EXF74517.1 - 3.4e-39 133.5 3.9 3.4e-39 133.5 3.9 2.7 3 1 0 3 3 3 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 EXF74517.1 - 1.3e-36 125.4 1.2 1.3e-36 125.4 1.2 3.0 2 1 0 2 2 2 1 Multicopper oxidase Cu-oxidase PF00394.22 EXF74517.1 - 8.2e-34 117.0 0.6 2e-33 115.8 0.1 2.0 2 0 0 2 2 2 1 Multicopper oxidase MFS_1 PF07690.16 EXF74518.1 - 1.7e-34 119.3 24.9 1.7e-34 119.3 24.9 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF74518.1 - 3.1e-13 49.4 14.6 4.1e-13 49.0 14.6 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter ALMT PF11744.8 EXF74518.1 - 0.18 10.6 1.8 0.26 10.1 1.8 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Trp_oprn_chp PF09534.10 EXF74518.1 - 0.73 9.6 9.6 0.084 12.7 1.7 2.8 3 0 0 3 3 3 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) DUF3938 PF13074.6 EXF74518.1 - 0.83 9.9 3.4 0.95 9.7 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3938) G_glu_transpept PF01019.21 EXF74519.1 - 1.1e-143 479.8 0.0 1.3e-143 479.5 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase Glutaredoxin PF00462.24 EXF74520.1 - 1.3e-15 57.4 0.0 2.3e-15 56.5 0.0 1.4 1 0 0 1 1 1 1 Glutaredoxin Flavoprotein PF02441.19 EXF74521.1 - 6.2e-48 162.5 0.1 7.3e-48 162.3 0.1 1.0 1 0 0 1 1 1 1 Flavoprotein Mpp10 PF04006.12 EXF74522.1 - 1.4e-110 370.6 72.9 4.2e-109 365.7 72.9 2.2 1 1 0 1 1 1 1 Mpp10 protein CIAPIN1 PF05093.13 EXF74523.1 - 2.3e-41 140.4 4.0 3.7e-41 139.7 4.0 1.3 1 0 0 1 1 1 1 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis DRE2_N PF16803.5 EXF74523.1 - 2.3e-33 115.2 0.0 3.4e-33 114.7 0.0 1.3 1 0 0 1 1 1 1 Fe-S cluster assembly protein DRE2 N-terminus Peptidase_S10 PF00450.22 EXF74524.1 - 1.7e-113 380.2 0.1 2e-113 380.0 0.1 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase RNA_Me_trans PF04252.13 EXF74525.1 - 6.9e-72 241.2 0.0 8.2e-72 241.0 0.0 1.0 1 0 0 1 1 1 1 Predicted SAM-dependent RNA methyltransferase Glyco_hydro_127 PF07944.12 EXF74526.1 - 8.6e-101 338.0 0.0 1.3e-100 337.3 0.0 1.3 1 0 0 1 1 1 1 Beta-L-arabinofuranosidase, GH127 zf-CCCH_4 PF18044.1 EXF74527.1 - 9.1e-07 28.5 2.1 1.4e-06 27.9 2.1 1.3 1 0 0 1 1 1 1 CCCH-type zinc finger zf_CCCH_4 PF18345.1 EXF74527.1 - 6.1e-06 26.1 5.5 1.2e-05 25.2 5.5 1.5 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH PF00642.24 EXF74527.1 - 8.4e-05 22.4 2.8 0.00016 21.5 2.8 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_3 PF15663.5 EXF74527.1 - 0.0062 16.7 0.2 0.016 15.4 0.2 1.7 1 0 0 1 1 1 1 Zinc-finger containing family zf-CCCH_2 PF14608.6 EXF74527.1 - 0.034 14.6 1.8 0.054 14.0 1.8 1.3 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger Torus PF16131.5 EXF74527.1 - 0.15 12.8 0.1 0.15 12.8 0.1 3.2 4 0 0 4 4 4 0 Torus domain WSD PF15613.6 EXF74527.1 - 3.1 8.3 5.5 1.2 9.7 1.4 2.5 2 0 0 2 2 2 0 Williams-Beuren syndrome DDT (WSD), D-TOX E motif Sec1 PF00995.23 EXF74528.1 - 1.8e-126 423.7 0.0 2.1e-126 423.5 0.0 1.0 1 0 0 1 1 1 1 Sec1 family Gpi1 PF05024.15 EXF74529.1 - 4.5e-77 258.4 8.5 7.8e-77 257.6 8.5 1.4 1 0 0 1 1 1 1 N-acetylglucosaminyl transferase component (Gpi1) UPF0203 PF05254.12 EXF74529.1 - 2.9e-25 88.3 2.5 5.7e-25 87.3 2.5 1.5 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0203) 7tm_1 PF00001.21 EXF74529.1 - 0.0038 16.6 0.8 0.0038 16.6 0.8 1.9 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) COX17 PF05051.13 EXF74529.1 - 0.0067 16.7 0.4 0.015 15.7 0.4 1.5 1 0 0 1 1 1 1 Cytochrome C oxidase copper chaperone (COX17) Cmc1 PF08583.10 EXF74529.1 - 0.32 11.1 3.1 1.2 9.2 0.1 2.5 1 1 1 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like DNA_pol_A_exo1 PF01612.20 EXF74530.1 - 7.8e-40 136.4 0.3 1.2e-39 135.8 0.3 1.3 1 0 0 1 1 1 1 3'-5' exonuclease PMC2NT PF08066.12 EXF74530.1 - 3.7e-24 85.2 0.5 3.7e-24 85.2 0.5 2.4 3 0 0 3 3 3 1 PMC2NT (NUC016) domain HRDC PF00570.23 EXF74530.1 - 2.5e-11 43.4 0.9 1e-10 41.4 0.0 2.5 3 0 0 3 3 3 1 HRDC domain Borrelia_P83 PF05262.11 EXF74530.1 - 0.079 11.4 40.4 0.13 10.8 40.4 1.3 1 0 0 1 1 1 0 Borrelia P83/100 protein Hamartin PF04388.12 EXF74530.1 - 5.4 5.6 16.9 9.8 4.7 16.9 1.3 1 0 0 1 1 1 0 Hamartin protein 2-Hacid_dh_C PF02826.19 EXF74531.1 - 1.2e-38 132.3 0.1 2.2e-36 124.9 0.1 2.7 2 1 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EXF74531.1 - 4.8e-18 65.1 0.1 6.6e-18 64.7 0.1 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 EXF74531.1 - 0.00046 20.4 0.8 0.0014 18.8 0.8 1.8 1 1 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase ADH_zinc_N PF00107.26 EXF74531.1 - 0.0028 17.6 2.7 0.011 15.7 2.1 2.2 2 1 0 2 2 2 1 Zinc-binding dehydrogenase F420_oxidored PF03807.17 EXF74531.1 - 0.0062 17.1 0.5 0.027 15.1 0.5 2.2 1 1 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent AdoHcyase_NAD PF00670.21 EXF74531.1 - 0.019 15.1 0.3 11 6.0 0.1 2.8 3 0 0 3 3 3 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Sacchrp_dh_NADP PF03435.18 EXF74531.1 - 0.026 14.8 0.1 0.058 13.7 0.1 1.6 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain IlvN PF07991.12 EXF74531.1 - 0.028 14.0 0.1 0.055 13.0 0.1 1.4 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain XdhC_C PF13478.6 EXF74531.1 - 0.035 14.6 0.2 0.12 12.8 0.0 2.0 2 1 0 2 2 2 0 XdhC Rossmann domain ApbA PF02558.16 EXF74531.1 - 0.12 12.0 0.1 0.38 10.4 0.1 1.9 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA Methyltransf_23 PF13489.6 EXF74534.1 - 2.8e-19 69.6 0.0 4.3e-19 68.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF74534.1 - 4.5e-10 40.1 0.0 9.9e-10 39.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF74534.1 - 4.9e-08 33.5 0.0 9.7e-08 32.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF74534.1 - 2.4e-07 31.4 0.0 1.7e-06 28.7 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF74534.1 - 1.1e-06 28.5 0.0 1.5e-05 24.8 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EXF74534.1 - 0.0087 15.6 0.0 0.018 14.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain CMAS PF02353.20 EXF74534.1 - 0.018 14.3 0.0 0.039 13.2 0.0 1.4 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase PrmA PF06325.13 EXF74534.1 - 0.074 12.4 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Etmic-2 PF06670.11 EXF74534.1 - 0.33 9.8 2.6 0.47 9.3 2.6 1.2 1 0 0 1 1 1 0 Microneme protein Etmic-2 HpcH_HpaI PF03328.14 EXF74536.1 - 9.3e-25 87.1 0.0 1.4e-24 86.5 0.0 1.2 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family PK PF00224.21 EXF74536.1 - 0.0015 17.5 0.1 0.0021 17.0 0.1 1.2 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain DmpG_comm PF07836.11 EXF74536.1 - 0.14 11.7 0.1 3.4 7.3 0.1 2.4 1 1 0 1 1 1 0 DmpG-like communication domain Aminotran_1_2 PF00155.21 EXF74537.1 - 2.1e-73 247.6 0.0 2.3e-73 247.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.7 EXF74537.1 - 0.071 11.9 0.0 0.081 11.7 0.0 1.2 1 0 0 1 1 1 0 Alanine-glyoxylate amino-transferase INPP5B_PH PF16776.5 EXF74537.1 - 0.18 11.5 0.0 0.66 9.7 0.0 1.8 2 0 0 2 2 2 0 Type II inositol 1,4,5-trisphosphate 5-phosphatase PH domain LRR_RI_capping PF18779.1 EXF74537.1 - 1 9.1 3.1 1.3 8.7 0.1 2.2 2 0 0 2 2 2 0 Capping Ribonuclease inhibitor Leucine Rich Repeat Methyltransf_2 PF00891.18 EXF74538.1 - 3.8e-19 68.8 0.0 5.3e-19 68.3 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain MFS_1 PF07690.16 EXF74541.1 - 1.3e-21 76.9 49.0 1.3e-21 76.9 49.0 2.4 1 1 1 2 2 2 1 Major Facilitator Superfamily Amidohydro_1 PF01979.20 EXF74542.1 - 2.2e-46 158.8 0.2 2.6e-46 158.5 0.2 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EXF74542.1 - 1.8e-23 83.8 0.1 6.2e-16 58.9 0.1 2.2 2 0 0 2 2 2 2 Amidohydrolase family DPBB_1 PF03330.18 EXF74543.1 - 8.8e-08 32.3 1.3 6.6e-07 29.5 0.3 2.7 2 1 0 2 2 2 1 Lytic transglycolase Pollen_allerg_1 PF01357.21 EXF74543.1 - 1e-05 25.5 3.8 2.2e-05 24.4 3.8 1.5 1 0 0 1 1 1 1 Pollen allergen Barwin PF00967.17 EXF74543.1 - 0.00029 20.7 1.2 0.00065 19.5 0.1 2.0 2 0 0 2 2 2 1 Barwin family Toxin_28 PF08115.11 EXF74543.1 - 0.42 10.5 8.8 0.21 11.5 3.4 2.4 2 0 0 2 2 2 0 SFI toxin family Fungal_trans PF04082.18 EXF74544.1 - 8.7e-19 67.6 0.1 7.2e-18 64.6 0.1 2.4 2 1 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF74544.1 - 1.4e-08 34.8 13.3 2.4e-08 34.0 13.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RasGAP_C PF03836.15 EXF74544.1 - 0.16 12.1 0.1 0.29 11.3 0.1 1.3 1 0 0 1 1 1 0 RasGAP C-terminus AA_permease PF00324.21 EXF74545.1 - 2.6e-112 375.9 43.5 3.1e-112 375.6 43.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EXF74545.1 - 7e-33 114.1 45.8 8.5e-33 113.8 45.8 1.1 1 0 0 1 1 1 1 Amino acid permease ADH_zinc_N PF00107.26 EXF74546.1 - 4.8e-11 42.7 0.3 2.3e-10 40.5 0.1 2.2 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EXF74546.1 - 5e-06 26.4 0.0 8.9e-06 25.6 0.0 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain TMEM215 PF15746.5 EXF74546.1 - 0.016 14.7 0.9 0.033 13.7 0.9 1.4 1 0 0 1 1 1 0 TMEM215 family zf-LITAF-like PF10601.9 EXF74547.1 - 8.8e-16 57.9 15.5 1.2e-15 57.5 15.5 1.2 1 0 0 1 1 1 1 LITAF-like zinc ribbon domain HET PF06985.11 EXF74548.1 - 1e-11 45.4 8.8 1.9e-10 41.2 1.1 2.8 2 1 1 3 3 3 2 Heterokaryon incompatibility protein (HET) Lyase_1 PF00206.20 EXF74549.1 - 4.8e-89 298.8 0.0 6.1e-89 298.5 0.0 1.1 1 0 0 1 1 1 1 Lyase ASL_C2 PF14698.6 EXF74549.1 - 4e-26 91.6 0.0 8.5e-26 90.5 0.0 1.6 1 0 0 1 1 1 1 Argininosuccinate lyase C-terminal Transp_cyt_pur PF02133.15 EXF74550.1 - 9.4e-19 67.5 33.6 1.5e-18 66.8 33.6 1.3 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin ILVD_EDD PF00920.21 EXF74551.1 - 9.2e-197 654.7 0.1 1.1e-196 654.5 0.1 1.0 1 0 0 1 1 1 1 Dehydratase family Phage_BR0599 PF09356.10 EXF74551.1 - 0.15 12.4 0.0 7 7.1 0.0 2.5 2 0 0 2 2 2 0 Phage conserved hypothetical protein BR0599 Epimerase PF01370.21 EXF74552.1 - 6.9e-23 81.4 0.0 1.1e-22 80.7 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EXF74552.1 - 2.9e-14 53.2 0.0 4.8e-14 52.5 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 EXF74552.1 - 3.5e-12 45.9 0.0 4.9e-12 45.4 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 EXF74552.1 - 9.4e-10 38.1 0.0 2.8e-07 30.0 0.0 2.2 2 0 0 2 2 2 2 Male sterility protein RmlD_sub_bind PF04321.17 EXF74552.1 - 5e-08 32.4 0.0 8.3e-08 31.7 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_10 PF13460.6 EXF74552.1 - 1.3e-07 31.7 0.0 2.4e-07 30.8 0.0 1.5 1 1 0 1 1 1 1 NAD(P)H-binding Polysacc_synt_2 PF02719.15 EXF74552.1 - 5.7e-06 25.7 0.0 1.9e-05 24.0 0.0 1.7 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein KR PF08659.10 EXF74552.1 - 0.061 13.2 0.2 8.3 6.3 0.0 2.3 2 0 0 2 2 2 0 KR domain HATPase_c PF02518.26 EXF74553.1 - 3.8e-28 98.2 0.1 7e-28 97.4 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EXF74553.1 - 5.5e-22 78.0 0.2 1.3e-21 76.8 0.2 1.7 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 EXF74553.1 - 9.1e-22 76.9 0.5 2.9e-21 75.3 0.1 2.2 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain PAS_3 PF08447.12 EXF74553.1 - 5.2e-18 65.1 0.3 1.7e-17 63.5 0.3 2.0 1 0 0 1 1 1 1 PAS fold PAS_4 PF08448.10 EXF74553.1 - 7.9e-13 48.6 0.1 5.3e-06 26.6 0.0 4.6 4 1 0 4 4 4 2 PAS fold PAS_9 PF13426.7 EXF74553.1 - 2.7e-12 46.8 0.0 1.3e-05 25.3 0.0 4.5 4 0 0 4 4 4 3 PAS domain PAS PF00989.25 EXF74553.1 - 1.9e-08 34.3 0.0 0.018 15.0 0.0 4.3 4 0 0 4 4 4 2 PAS fold PAS_8 PF13188.7 EXF74553.1 - 0.00017 21.5 0.2 0.15 12.2 0.1 4.0 4 0 0 4 4 4 1 PAS domain PAS_11 PF14598.6 EXF74553.1 - 0.075 13.2 0.0 0.17 12.0 0.0 1.6 1 0 0 1 1 1 0 PAS domain LPP PF04728.13 EXF74553.1 - 0.37 11.2 2.7 0.99 9.8 2.7 1.7 1 0 0 1 1 1 0 Lipoprotein leucine-zipper Pkinase PF00069.25 EXF74554.1 - 3e-25 89.1 0.0 4.3e-25 88.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF74554.1 - 3.6e-09 36.3 0.0 7e-09 35.4 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EXF74554.1 - 0.036 12.9 0.0 0.05 12.4 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase COG5 PF10392.9 EXF74555.1 - 0.053 13.7 0.2 0.1 12.8 0.2 1.5 1 0 0 1 1 1 0 Golgi transport complex subunit 5 Helo_like_N PF17111.5 EXF74555.1 - 0.067 12.6 0.5 0.16 11.3 0.4 1.6 1 1 0 1 1 1 0 Fungal N-terminal domain of STAND proteins SesA PF17107.5 EXF74555.1 - 0.16 12.2 0.6 0.29 11.3 0.6 1.4 1 0 0 1 1 1 0 N-terminal domain on NACHT_NTPase and P-loop NTPases Memo PF01875.17 EXF74556.1 - 1.7e-73 247.1 0.0 2.5e-73 246.6 0.0 1.3 1 0 0 1 1 1 1 Memo-like protein Ank_5 PF13857.6 EXF74556.1 - 0.0007 19.8 0.0 0.046 14.0 0.0 2.8 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EXF74556.1 - 0.0015 19.1 0.0 0.014 15.9 0.0 2.4 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EXF74556.1 - 0.052 14.1 0.0 1 10.2 0.0 2.8 2 0 0 2 2 2 0 Ankyrin repeat Ank_4 PF13637.6 EXF74556.1 - 0.17 12.5 0.0 21 5.8 0.0 2.9 2 0 0 2 2 2 0 Ankyrin repeats (many copies) Syntaxin PF00804.25 EXF74557.1 - 3.8e-17 62.6 11.0 3.8e-17 62.6 11.0 2.1 1 1 0 2 2 2 1 Syntaxin SNARE PF05739.19 EXF74557.1 - 1.2e-08 34.8 2.9 1.7e-08 34.3 0.3 2.5 2 0 0 2 2 2 1 SNARE domain Chordopox_A33R PF05966.12 EXF74557.1 - 0.043 13.1 0.2 0.33 10.2 0.0 2.1 2 0 0 2 2 2 0 Chordopoxvirus A33R protein DUF2207 PF09972.9 EXF74557.1 - 0.13 10.9 0.0 0.18 10.5 0.0 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) V-SNARE PF05008.15 EXF74557.1 - 0.15 12.5 13.1 0.1 13.0 2.3 3.6 3 1 1 4 4 4 0 Vesicle transport v-SNARE protein N-terminus DUF515 PF04415.12 EXF74557.1 - 0.25 9.7 3.2 0.25 9.7 2.2 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF515) BLOC1_2 PF10046.9 EXF74557.1 - 0.28 11.5 7.8 3.9 7.8 2.2 3.4 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Allexi_40kDa PF05549.11 EXF74557.1 - 0.89 9.0 7.0 1.2 8.6 0.4 2.2 2 0 0 2 2 2 0 Allexivirus 40kDa protein TMCO5 PF14992.6 EXF74557.1 - 0.97 8.9 7.8 58 3.1 7.8 2.1 1 1 0 1 1 1 0 TMCO5 family ISG65-75 PF11727.8 EXF74557.1 - 1.2 8.3 7.2 0.78 8.9 0.0 2.3 2 0 0 2 2 2 0 Invariant surface glycoprotein DUF2229 PF09989.9 EXF74557.1 - 2.1 8.0 5.1 14 5.3 5.1 2.1 1 1 0 1 1 1 0 CoA enzyme activase uncharacterised domain (DUF2229) Gp-FAR-1 PF05823.12 EXF74557.1 - 2.2 8.6 5.3 37 4.6 2.2 2.6 1 1 2 3 3 3 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) Laminin_II PF06009.12 EXF74557.1 - 5.5 7.0 10.6 6.4 6.8 3.3 2.4 2 1 0 2 2 2 0 Laminin Domain II FAD_binding_4 PF01565.23 EXF74558.1 - 9.8e-25 86.9 3.3 2.7e-24 85.5 2.3 2.1 2 0 0 2 2 2 1 FAD binding domain BBE PF08031.12 EXF74558.1 - 0.0066 16.5 0.3 0.019 15.1 0.1 1.9 2 0 0 2 2 2 1 Berberine and berberine like ACTH_assoc PF16102.5 EXF74559.1 - 0.77 10.7 0.1 0.77 10.7 0.1 4.4 5 0 0 5 5 5 0 ACTH-associated domain zf-ANAPC11 PF12861.7 EXF74560.1 - 6.5e-45 151.1 10.8 1e-44 150.5 10.8 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 EXF74560.1 - 2.1e-21 76.0 12.4 4.6e-21 74.8 12.4 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 EXF74560.1 - 2.6e-07 30.8 14.8 3.4e-06 27.3 14.8 2.4 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 EXF74560.1 - 0.0001 22.1 11.8 0.00033 20.4 11.8 2.0 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EXF74560.1 - 0.00022 21.2 11.0 0.00091 19.2 5.1 2.9 2 1 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EXF74560.1 - 0.002 17.9 7.3 0.002 17.9 7.3 2.3 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.6 EXF74560.1 - 0.0082 15.9 3.0 0.0082 15.9 3.0 2.4 1 1 1 2 2 2 1 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.6 EXF74560.1 - 0.009 16.1 9.5 0.016 15.3 8.0 2.3 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING Zn_ribbon_17 PF17120.5 EXF74560.1 - 0.011 15.4 10.9 0.059 13.0 10.9 2.0 1 1 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-C3HC4_2 PF13923.6 EXF74560.1 - 0.015 15.1 12.7 0.015 15.1 12.7 2.6 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) FANCL_C PF11793.8 EXF74560.1 - 0.015 15.4 15.1 0.18 12.0 15.1 2.8 1 1 0 1 1 1 0 FANCL C-terminal domain zf-Nse PF11789.8 EXF74560.1 - 0.042 13.7 5.2 0.095 12.5 5.2 1.6 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Rad50_zn_hook PF04423.14 EXF74560.1 - 0.1 12.4 2.2 0.4 10.6 0.1 2.4 2 0 0 2 2 2 0 Rad50 zinc hook motif RINGv PF12906.7 EXF74560.1 - 1.3 9.2 10.3 3.1 8.0 10.0 1.9 1 1 0 1 1 1 0 RING-variant domain TerY_C PF15616.6 EXF74560.1 - 1.4 9.1 7.7 2 8.5 6.0 1.9 1 1 1 2 2 2 0 TerY-C metal binding domain zf-RING_11 PF17123.5 EXF74560.1 - 1.6 8.6 13.1 1.3 8.9 9.4 2.7 2 1 0 2 2 2 0 RING-like zinc finger zf-HIT PF04438.16 EXF74560.1 - 1.8 8.5 7.7 4.3 7.3 3.8 2.4 2 0 0 2 2 2 0 HIT zinc finger zf-RING_5 PF14634.6 EXF74560.1 - 2.2 8.3 18.3 25 4.9 17.3 3.1 2 1 1 3 3 3 0 zinc-RING finger domain UBZ_FAAP20 PF15750.5 EXF74560.1 - 2.5 8.1 6.5 7 6.7 0.8 3.1 2 1 0 2 2 2 0 Ubiquitin-binding zinc-finger Prok-RING_4 PF14447.6 EXF74560.1 - 2.9 7.8 13.3 8.6 6.3 9.6 2.5 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-RING-like PF08746.11 EXF74560.1 - 4.9 7.5 11.7 24 5.3 11.7 2.1 1 1 0 1 1 1 0 RING-like domain Rhodanese PF00581.20 EXF74561.1 - 1.4e-18 67.4 0.0 1.7e-10 41.4 0.0 2.2 2 0 0 2 2 2 2 Rhodanese-like domain Ribosomal_S5 PF00333.20 EXF74562.1 - 9e-27 92.9 0.8 2.1e-26 91.7 0.8 1.6 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.15 EXF74562.1 - 9.4e-24 82.7 0.0 1.6e-23 81.9 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain FoP_duplication PF13865.6 EXF74562.1 - 2.6 8.6 14.3 6.8 7.3 14.3 1.6 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 CDC45 PF02724.14 EXF74563.1 - 3.5 5.8 8.2 6.4 4.9 8.2 1.3 1 0 0 1 1 1 0 CDC45-like protein gag-asp_proteas PF13975.6 EXF74564.1 - 0.027 15.0 0.0 0.07 13.7 0.0 1.6 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Hemerythrin PF01814.23 EXF74564.1 - 0.028 15.0 2.2 0.041 14.5 0.4 2.1 2 0 0 2 2 2 0 Hemerythrin HHE cation binding domain bZIP_1 PF00170.21 EXF74565.1 - 0.0043 17.1 4.5 0.008 16.2 4.5 1.4 1 0 0 1 1 1 1 bZIP transcription factor IGR PF09597.10 EXF74566.1 - 9.3e-23 80.1 0.1 1.8e-22 79.2 0.1 1.5 1 0 0 1 1 1 1 IGR protein motif SNF2_N PF00176.23 EXF74567.1 - 2.2e-58 197.6 0.0 4e-58 196.8 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain zf-C3HC4_3 PF13920.6 EXF74567.1 - 1e-09 38.1 10.7 2.2e-09 37.0 10.7 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EXF74567.1 - 9.7e-08 31.8 13.7 2e-07 30.7 13.7 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EXF74567.1 - 1.2e-07 31.9 13.1 2.4e-07 31.0 13.1 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EXF74567.1 - 8.6e-07 28.7 14.2 2e-06 27.5 14.2 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EXF74567.1 - 1.5e-06 27.9 10.0 3.2e-06 26.9 10.0 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 EXF74567.1 - 0.0001 22.5 12.0 0.00028 21.1 12.0 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 EXF74567.1 - 0.00054 19.9 12.6 0.0012 18.8 12.6 1.6 1 0 0 1 1 1 1 zinc-RING finger domain Helicase_C PF00271.31 EXF74567.1 - 0.0017 18.7 0.0 0.0036 17.6 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-RING_UBOX PF13445.6 EXF74567.1 - 0.007 16.4 11.4 0.018 15.0 11.4 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_4 PF14570.6 EXF74567.1 - 0.012 15.4 6.9 0.033 14.0 6.9 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain IBR PF01485.21 EXF74567.1 - 0.071 13.3 6.3 0.19 11.9 6.3 1.8 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain zf-C3HC4_4 PF15227.6 EXF74567.1 - 0.076 13.2 9.8 0.18 12.0 9.8 1.7 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-ANAPC11 PF12861.7 EXF74567.1 - 0.39 10.8 6.8 0.8 9.8 6.8 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_10 PF16685.5 EXF74567.1 - 0.99 9.6 7.3 2.2 8.5 7.3 1.5 1 0 0 1 1 1 0 zinc RING finger of MSL2 DZR PF12773.7 EXF74567.1 - 1.4 9.0 5.2 3.4 7.7 5.2 1.7 1 0 0 1 1 1 0 Double zinc ribbon Sec10 PF07393.11 EXF74568.1 - 5e-167 557.4 0.0 6.3e-167 557.1 0.0 1.0 1 0 0 1 1 1 1 Exocyst complex component Sec10 F-box-like PF12937.7 EXF74568.1 - 1.2e-07 31.5 0.3 5.4e-07 29.4 0.0 2.2 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EXF74568.1 - 0.0017 18.2 0.0 0.0037 17.1 0.0 1.6 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 EXF74568.1 - 0.038 13.9 0.0 0.1 12.5 0.0 1.7 1 0 0 1 1 1 0 F-box Pkinase PF00069.25 EXF74569.1 - 1.9e-64 217.6 0.0 2.3e-64 217.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF74569.1 - 2.6e-35 122.0 0.0 3.6e-35 121.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EXF74569.1 - 0.0011 18.3 0.0 0.0021 17.5 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Frag1 PF10277.9 EXF74570.1 - 1.5e-42 145.6 22.6 1.7e-42 145.5 22.6 1.0 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family Eisosome1 PF12757.7 EXF74571.1 - 5.5e-40 136.5 15.1 5.5e-40 136.5 15.1 4.4 4 2 1 5 5 5 1 Eisosome protein 1 Y_phosphatase3 PF13350.6 EXF74572.1 - 1.3e-43 149.6 0.0 2.6e-43 148.6 0.0 1.4 1 1 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase2 PF03162.13 EXF74572.1 - 3.5e-07 29.9 0.0 1.3e-06 28.1 0.0 1.7 2 0 0 2 2 2 1 Tyrosine phosphatase family Myotub-related PF06602.14 EXF74572.1 - 0.0012 17.9 0.0 0.0019 17.2 0.0 1.3 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain DSPc PF00782.20 EXF74572.1 - 0.0066 16.3 0.0 1.6 8.6 0.0 2.2 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EXF74572.1 - 0.0068 16.0 0.0 0.0095 15.5 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Methyltransf_12 PF08242.12 EXF74573.1 - 1.1e-15 58.1 0.1 3.6e-15 56.5 0.0 1.9 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF74573.1 - 1.1e-14 54.9 0.0 2.4e-14 53.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF74573.1 - 2.1e-11 44.3 0.0 4.5e-11 43.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EXF74573.1 - 3.3e-11 43.3 0.0 5.7e-11 42.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF74573.1 - 6.1e-09 35.8 0.0 9.3e-09 35.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_24 PF13578.6 EXF74573.1 - 4.5e-06 27.6 0.0 1e-05 26.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EXF74573.1 - 1.8e-05 24.2 0.0 2.7e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 EXF74573.1 - 6e-05 22.7 0.0 9.7e-05 22.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_8 PF05148.15 EXF74573.1 - 0.003 17.4 0.0 0.041 13.7 0.0 2.3 1 1 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_16 PF10294.9 EXF74573.1 - 0.0062 16.3 0.0 0.0099 15.6 0.0 1.2 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_32 PF13679.6 EXF74573.1 - 0.0066 16.4 0.0 0.013 15.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain DUF3419 PF11899.8 EXF74573.1 - 0.0077 15.5 0.0 0.014 14.6 0.0 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF3419) NNMT_PNMT_TEMT PF01234.17 EXF74573.1 - 0.029 13.6 0.0 5.5 6.1 0.0 2.3 1 1 1 2 2 2 0 NNMT/PNMT/TEMT family PrmA PF06325.13 EXF74573.1 - 0.04 13.3 0.0 0.063 12.7 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) TPR_11 PF13414.6 EXF74574.1 - 3.8e-14 52.1 1.3 4.1e-05 23.2 0.0 3.9 3 1 1 4 4 4 3 TPR repeat TPR_14 PF13428.6 EXF74574.1 - 4.3e-10 39.6 9.8 0.00029 21.4 0.1 6.0 3 1 4 7 7 7 2 Tetratricopeptide repeat TPR_19 PF14559.6 EXF74574.1 - 1.1e-08 35.4 5.2 1.6e-06 28.5 0.5 4.4 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_8 PF13181.6 EXF74574.1 - 3.4e-07 29.9 0.4 0.031 14.5 0.2 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.17 EXF74574.1 - 4e-07 29.7 6.9 0.00013 21.8 0.5 5.2 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_16 PF13432.6 EXF74574.1 - 5.1e-07 30.2 3.8 4.3e-05 24.1 0.5 3.6 4 1 0 4 4 3 1 Tetratricopeptide repeat TPR_9 PF13371.6 EXF74574.1 - 2.5e-06 27.6 0.8 4.9e-05 23.4 0.1 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 EXF74574.1 - 3.6e-06 27.0 0.4 0.0012 19.1 0.1 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 EXF74574.1 - 1.7e-05 25.0 6.2 0.29 11.5 1.3 4.6 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_6 PF13174.6 EXF74574.1 - 0.00031 21.2 0.5 1.3 9.8 0.1 4.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.28 EXF74574.1 - 0.00039 20.1 0.3 0.00039 20.1 0.3 3.3 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_20 PF14561.6 EXF74574.1 - 0.0007 19.9 2.4 0.0041 17.4 0.1 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat Methyltransf_1N PF02870.15 EXF74574.1 - 0.003 18.3 0.0 0.011 16.5 0.0 2.0 1 0 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain ChAPs PF09295.10 EXF74574.1 - 0.0075 15.3 0.0 0.0097 15.0 0.0 1.1 1 0 0 1 1 1 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_7 PF13176.6 EXF74574.1 - 0.018 15.1 3.5 0.11 12.6 0.3 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat NCA2 PF08637.10 EXF74574.1 - 0.024 13.8 0.0 0.055 12.6 0.0 1.5 2 0 0 2 2 2 0 ATP synthase regulation protein NCA2 ANAPC3 PF12895.7 EXF74574.1 - 0.029 14.6 0.2 0.098 12.9 0.1 2.0 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 BTAD PF03704.17 EXF74574.1 - 0.12 12.8 3.0 0.91 10.0 0.0 3.0 2 2 1 3 3 3 0 Bacterial transcriptional activator domain Polyketide_cyc PF03364.20 EXF74576.1 - 1.4e-26 93.2 0.0 3.3e-26 92.0 0.0 1.6 1 1 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc2 PF10604.9 EXF74576.1 - 6.3e-05 23.3 1.2 0.00022 21.5 1.2 1.8 1 1 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Adaptin_N PF01602.20 EXF74577.1 - 6.5e-74 249.4 0.0 1.1e-73 248.7 0.0 1.3 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EXF74577.1 - 8.7e-05 22.6 0.0 0.0095 16.0 0.0 2.4 2 0 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EXF74577.1 - 0.05 14.0 0.1 0.38 11.2 0.0 2.5 2 1 0 2 2 2 0 HEAT repeats RhoGAP PF00620.27 EXF74578.1 - 6.2e-16 58.6 0.0 1.4e-15 57.5 0.0 1.6 1 0 0 1 1 1 1 RhoGAP domain DEP PF00610.21 EXF74578.1 - 2.7e-13 49.8 0.0 5.8e-13 48.7 0.0 1.6 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) FCH PF00611.23 EXF74578.1 - 1.3e-11 44.6 0.0 4.3e-11 42.9 0.0 1.9 1 0 0 1 1 1 1 Fes/CIP4, and EFC/F-BAR homology domain BAR PF03114.18 EXF74578.1 - 0.029 14.0 0.8 0.083 12.5 0.8 1.7 1 0 0 1 1 1 0 BAR domain DUF2951 PF11166.8 EXF74578.1 - 0.04 14.1 0.6 0.32 11.2 0.0 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2951) Peptidase_M19 PF01244.21 EXF74579.1 - 8.5e-105 350.4 0.0 9.9e-105 350.2 0.0 1.0 1 0 0 1 1 1 1 Membrane dipeptidase (Peptidase family M19) Amidohydro_2 PF04909.14 EXF74579.1 - 0.032 14.0 0.0 0.068 12.9 0.0 1.4 1 1 0 1 1 1 0 Amidohydrolase Ribosomal_S13 PF00416.22 EXF74580.1 - 8.7e-15 55.2 0.1 2e-12 47.6 0.1 2.0 1 1 0 1 1 1 1 Ribosomal protein S13/S18 Pro_isomerase PF00160.21 EXF74581.1 - 9e-50 169.0 0.4 1.2e-49 168.6 0.4 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Trm112p PF03966.16 EXF74582.1 - 8.7e-19 67.9 0.1 1.1e-18 67.6 0.1 1.1 1 0 0 1 1 1 1 Trm112p-like protein Zn_ribbon_recom PF13408.6 EXF74582.1 - 0.07 13.7 0.3 0.11 13.0 0.3 1.3 1 0 0 1 1 1 0 Recombinase zinc beta ribbon domain ATP-synt_S1 PF05827.12 EXF74583.1 - 0.0038 17.1 0.0 0.0073 16.1 0.0 1.4 1 0 0 1 1 1 1 Vacuolar ATP synthase subunit S1 (ATP6S1) eIF-3_zeta PF05091.12 EXF74583.1 - 0.21 10.5 0.0 0.32 9.9 0.0 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Nop25 PF09805.9 EXF74584.1 - 1.7e-39 135.4 14.1 1.7e-39 135.4 14.1 2.6 2 1 1 3 3 3 1 Nucleolar protein 12 (25kDa) EIIBC-GUT_N PF03612.14 EXF74584.1 - 1.7 8.3 12.1 0.18 11.6 2.9 2.1 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus Tropomyosin_1 PF12718.7 EXF74585.1 - 3.4e-53 179.6 29.7 4e-53 179.4 29.7 1.0 1 0 0 1 1 1 1 Tropomyosin like Tropomyosin PF00261.20 EXF74585.1 - 3.9e-08 33.0 30.1 0.00013 21.4 11.9 3.0 1 1 2 3 3 3 3 Tropomyosin CENP-F_leu_zip PF10473.9 EXF74585.1 - 0.00017 21.7 3.9 0.00017 21.7 3.9 2.9 1 1 1 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF724 PF05266.14 EXF74585.1 - 0.00046 20.1 22.5 0.018 14.9 8.2 2.0 2 0 0 2 2 2 2 Protein of unknown function (DUF724) Spc7 PF08317.11 EXF74585.1 - 0.00046 19.2 30.6 0.0085 15.0 12.3 2.0 1 1 1 2 2 2 2 Spc7 kinetochore protein Lebercilin PF15619.6 EXF74585.1 - 0.00063 19.5 28.5 0.1 12.3 14.6 2.1 1 1 1 2 2 2 2 Ciliary protein causing Leber congenital amaurosis disease DUF4200 PF13863.6 EXF74585.1 - 0.00078 19.8 31.4 0.092 13.2 9.2 2.4 2 1 0 2 2 2 2 Domain of unknown function (DUF4200) ATG16 PF08614.11 EXF74585.1 - 0.0012 19.1 29.3 0.14 12.4 12.8 2.2 1 1 1 2 2 2 1 Autophagy protein 16 (ATG16) ADIP PF11559.8 EXF74585.1 - 0.0013 18.8 27.5 0.0034 17.5 6.8 3.1 1 1 2 3 3 3 1 Afadin- and alpha -actinin-Binding Taxilin PF09728.9 EXF74585.1 - 0.0014 17.8 26.5 0.21 10.7 13.3 2.1 1 1 1 2 2 2 2 Myosin-like coiled-coil protein Uso1_p115_C PF04871.13 EXF74585.1 - 0.0015 18.9 32.1 0.053 13.9 13.1 2.0 1 1 1 2 2 2 2 Uso1 / p115 like vesicle tethering protein, C terminal region TACC_C PF05010.14 EXF74585.1 - 0.002 18.0 21.3 0.0098 15.7 11.3 2.3 1 1 1 2 2 2 1 Transforming acidic coiled-coil-containing protein (TACC), C-terminal HOOK PF05622.12 EXF74585.1 - 0.0041 15.4 23.5 0.0054 14.9 23.5 1.2 1 0 0 1 1 1 1 HOOK protein TMF_TATA_bd PF12325.8 EXF74585.1 - 0.0044 17.2 21.9 0.051 13.8 13.5 2.4 1 1 1 2 2 2 1 TATA element modulatory factor 1 TATA binding GAS PF13851.6 EXF74585.1 - 0.0071 15.7 28.7 0.56 9.5 5.5 2.1 1 1 0 1 1 1 1 Growth-arrest specific micro-tubule binding Surfac_D-trimer PF09006.11 EXF74585.1 - 0.0088 15.9 0.9 0.044 13.7 0.0 2.5 3 0 0 3 3 1 1 Lung surfactant protein D coiled-coil trimerisation FlaC_arch PF05377.11 EXF74585.1 - 0.012 15.9 18.0 0.24 11.8 4.2 4.4 3 2 1 4 4 4 0 Flagella accessory protein C (FlaC) KLRAQ PF10205.9 EXF74585.1 - 0.014 15.6 20.5 0.036 14.3 6.5 3.0 1 1 2 3 3 3 0 Predicted coiled-coil domain-containing protein Fez1 PF06818.15 EXF74585.1 - 0.017 15.6 24.0 0.031 14.7 23.9 1.4 1 1 0 1 1 1 0 Fez1 ERM PF00769.19 EXF74585.1 - 0.019 14.8 33.3 0.038 13.8 15.6 2.0 1 1 1 2 2 2 0 Ezrin/radixin/moesin family Cast PF10174.9 EXF74585.1 - 0.019 13.2 20.9 0.024 12.9 20.9 1.1 1 0 0 1 1 1 0 RIM-binding protein of the cytomatrix active zone HMMR_C PF15908.5 EXF74585.1 - 0.02 15.1 4.1 0.02 15.1 4.1 2.5 1 1 0 2 2 2 0 Hyaluronan mediated motility receptor C-terminal Syntaxin_2 PF14523.6 EXF74585.1 - 0.021 15.2 3.8 0.021 15.2 3.8 2.2 2 0 0 2 2 2 0 Syntaxin-like protein T3SSipB PF16535.5 EXF74585.1 - 0.037 14.5 18.6 1 9.8 9.1 2.5 1 1 1 2 2 2 0 Type III cell invasion protein SipB DUF3450 PF11932.8 EXF74585.1 - 0.038 13.3 24.9 0.44 9.8 11.6 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) DUF1664 PF07889.12 EXF74585.1 - 0.052 13.6 13.6 0.28 11.2 3.2 3.0 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) TPR_MLP1_2 PF07926.12 EXF74585.1 - 0.053 13.6 32.6 0.17 12.0 9.1 2.5 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein bZIP_1 PF00170.21 EXF74585.1 - 0.055 13.6 30.0 0.23 11.6 3.7 4.8 3 2 2 5 5 4 0 bZIP transcription factor DUF4763 PF15960.5 EXF74585.1 - 0.061 12.6 15.7 0.17 11.2 3.5 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4763) CENP-K PF11802.8 EXF74585.1 - 0.062 12.9 16.6 0.53 9.8 4.7 2.0 1 1 1 2 2 2 0 Centromere-associated protein K APG6_N PF17675.1 EXF74585.1 - 0.062 13.8 36.0 1.3 9.5 11.2 2.3 1 1 1 2 2 2 0 Apg6 coiled-coil region EzrA PF06160.12 EXF74585.1 - 0.063 11.4 21.2 0.066 11.4 6.1 2.0 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA Syntaxin-6_N PF09177.11 EXF74585.1 - 0.064 13.8 15.8 1.3 9.6 6.1 2.7 1 1 1 2 2 2 0 Syntaxin 6, N-terminal KASH_CCD PF14662.6 EXF74585.1 - 0.076 12.8 28.4 0.063 13.1 25.6 2.5 1 1 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH Fmp27_WPPW PF10359.9 EXF74585.1 - 0.081 11.8 22.2 0.031 13.1 8.3 2.0 1 1 1 2 2 2 0 RNA pol II promoter Fmp27 protein domain Cortex-I_coil PF09304.10 EXF74585.1 - 0.082 13.1 21.6 5 7.4 5.9 3.3 1 1 2 3 3 3 0 Cortexillin I, coiled coil DUF3287 PF11690.8 EXF74585.1 - 0.086 12.6 4.2 0.66 9.7 0.3 2.8 1 1 1 3 3 3 0 Protein of unknown function (DUF3287) CASP_C PF08172.12 EXF74585.1 - 0.091 12.1 19.7 0.12 11.7 2.7 2.1 1 1 1 2 2 2 0 CASP C terminal UPF0242 PF06785.11 EXF74585.1 - 0.093 12.8 29.4 0.14 12.2 9.3 2.0 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Laminin_II PF06009.12 EXF74585.1 - 0.095 12.7 16.5 0.02 14.9 4.5 2.5 1 1 1 2 2 2 0 Laminin Domain II Jnk-SapK_ap_N PF09744.9 EXF74585.1 - 0.098 12.9 29.5 0.073 13.3 16.5 2.1 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 DUF5082 PF16888.5 EXF74585.1 - 0.11 12.8 19.6 1.7 8.9 6.2 3.0 1 1 2 3 3 3 0 Domain of unknown function (DUF5082) NPV_P10 PF05531.12 EXF74585.1 - 0.12 12.9 8.0 1.6 9.3 2.2 3.2 1 1 2 3 3 3 0 Nucleopolyhedrovirus P10 protein Filament PF00038.21 EXF74585.1 - 0.13 11.8 23.8 0.47 10.0 23.8 1.8 1 1 0 1 1 1 0 Intermediate filament protein DUF2203 PF09969.9 EXF74585.1 - 0.13 12.9 16.3 0.98 10.2 4.4 2.1 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) MAD PF05557.13 EXF74585.1 - 0.14 10.5 23.5 0.13 10.6 11.3 2.0 1 1 1 2 2 2 0 Mitotic checkpoint protein CLZ PF16526.5 EXF74585.1 - 0.14 12.5 23.7 0.75 10.2 1.7 3.7 1 1 2 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels SOGA PF11365.8 EXF74585.1 - 0.16 13.1 22.4 1.9 9.7 9.7 3.4 1 1 2 3 3 3 0 Protein SOGA Rab5-bind PF09311.11 EXF74585.1 - 0.19 11.1 22.7 0.79 9.1 8.5 2.0 2 0 0 2 2 2 0 Rabaptin-like protein Cep57_CLD_2 PF14197.6 EXF74585.1 - 0.2 11.7 24.7 1.7 8.8 3.7 4.2 2 2 0 2 2 2 0 Centrosome localisation domain of PPC89 KELK PF15796.5 EXF74585.1 - 0.26 11.8 30.1 0.3 11.6 3.3 3.7 1 1 3 4 4 4 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase HAP1_N PF04849.13 EXF74585.1 - 0.29 10.3 26.3 0.61 9.2 26.3 1.9 1 1 0 1 1 1 0 HAP1 N-terminal conserved region CALCOCO1 PF07888.11 EXF74585.1 - 0.31 9.9 27.6 1.8 7.3 9.6 2.0 1 1 1 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like LPP PF04728.13 EXF74585.1 - 0.36 11.2 10.9 15 6.1 0.1 4.2 3 1 0 3 3 3 0 Lipoprotein leucine-zipper Seryl_tRNA_N PF02403.22 EXF74585.1 - 0.51 10.6 24.1 0.72 10.1 0.3 3.1 1 1 1 2 2 1 0 Seryl-tRNA synthetase N-terminal domain VGPC1_C PF16799.5 EXF74585.1 - 0.51 10.3 8.8 0.46 10.5 3.8 2.9 2 1 0 2 2 2 0 C-terminal membrane-localisation domain of ion-channel, VCN1 Sec34 PF04136.15 EXF74585.1 - 0.65 9.9 14.0 0.23 11.3 2.9 2.3 2 0 0 2 2 2 0 Sec34-like family Alanine_zipper PF11839.8 EXF74585.1 - 0.75 10.2 11.3 1.5 9.3 2.1 3.8 1 1 2 3 3 3 0 Alanine-zipper, major outer membrane lipoprotein TANGO2 PF05742.12 EXF74585.1 - 0.81 9.7 6.6 1.4 8.9 6.6 1.5 1 1 0 1 1 1 0 Transport and Golgi organisation 2 PI3K_P85_iSH2 PF16454.5 EXF74585.1 - 0.98 9.0 21.1 3.7 7.1 21.2 1.9 1 1 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain TMF_DNA_bd PF12329.8 EXF74585.1 - 1.3 9.1 32.2 0.75 9.8 12.7 3.0 1 1 2 3 3 3 0 TATA element modulatory factor 1 DNA binding Lectin_N PF03954.14 EXF74585.1 - 1.5 8.6 14.4 0.84 9.4 3.6 2.6 1 1 2 3 3 3 0 Hepatic lectin, N-terminal domain DUF3584 PF12128.8 EXF74585.1 - 1.5 6.2 23.6 2.2 5.7 23.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) BRE1 PF08647.11 EXF74585.1 - 1.6 8.8 28.7 21 5.3 4.3 3.0 1 1 2 3 3 3 0 BRE1 E3 ubiquitin ligase DUF4407 PF14362.6 EXF74585.1 - 1.6 8.0 20.9 3.8 6.8 20.9 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DUF2730 PF10805.8 EXF74585.1 - 1.8 8.7 12.7 0.55 10.3 2.9 3.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2730) AAA_13 PF13166.6 EXF74585.1 - 1.9 7.0 22.2 0.27 9.8 7.0 2.0 1 1 0 2 2 2 0 AAA domain FUSC PF04632.12 EXF74585.1 - 2.1 6.7 5.8 2.3 6.6 5.8 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family XhlA PF10779.9 EXF74585.1 - 2.2 8.6 21.7 3.5 7.9 1.9 4.1 2 1 3 5 5 5 0 Haemolysin XhlA DUF4686 PF15742.5 EXF74585.1 - 2.2 7.3 28.6 1.3 8.1 9.4 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4686) CHDCT2 PF08074.11 EXF74585.1 - 2.3 8.4 9.1 0.26 11.4 3.0 2.0 1 1 1 2 2 2 0 CHDCT2 (NUC038) domain WXG100 PF06013.12 EXF74585.1 - 2.4 8.4 15.3 7.5 6.9 0.2 4.1 3 1 1 4 4 4 0 Proteins of 100 residues with WXG Atg14 PF10186.9 EXF74585.1 - 2.6 7.0 19.6 2 7.4 10.1 2.0 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF2937 PF11157.8 EXF74585.1 - 2.9 7.6 9.0 2.3 7.9 5.1 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2937) Methyltransf_9 PF08003.11 EXF74585.1 - 3 6.7 6.8 4.5 6.1 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1698) Fib_alpha PF08702.10 EXF74585.1 - 3.5 7.8 15.5 5.3 7.2 3.4 2.4 1 1 0 2 2 2 0 Fibrinogen alpha/beta chain family Rootletin PF15035.6 EXF74585.1 - 3.5 7.6 26.7 72 3.3 26.8 2.1 1 1 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion DHR10 PF18595.1 EXF74585.1 - 3.6 7.7 32.3 25 5.0 23.2 3.0 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain DUF4482 PF14818.6 EXF74585.1 - 4 8.3 20.8 0.25 12.2 2.0 3.1 1 1 2 3 3 3 0 Domain of unknown function (DUF4482) DUF745 PF05335.13 EXF74585.1 - 4 7.1 18.9 0.19 11.4 5.5 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF745) TRAF_BIRC3_bd PF16673.5 EXF74585.1 - 4.4 7.2 16.3 5.2 6.9 1.4 4.1 2 2 3 5 5 5 0 TNF receptor-associated factor BIRC3 binding domain CENP-H PF05837.12 EXF74585.1 - 4.6 7.7 23.7 12 6.3 0.2 3.0 1 1 2 3 3 3 0 Centromere protein H (CENP-H) CENP-Q PF13094.6 EXF74585.1 - 4.9 7.3 30.0 24 5.1 16.5 3.4 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit FAM76 PF16046.5 EXF74585.1 - 5.2 6.3 20.6 3.6 6.9 10.6 2.0 1 1 1 2 2 2 0 FAM76 protein ZapB PF06005.12 EXF74585.1 - 5.5 7.5 36.2 12 6.4 0.6 4.1 1 1 2 3 3 3 0 Cell division protein ZapB HAUS-augmin3 PF14932.6 EXF74585.1 - 5.6 6.5 26.6 2.7 7.5 11.5 2.5 1 1 2 3 3 3 0 HAUS augmin-like complex subunit 3 CorA PF01544.18 EXF74585.1 - 6.2 6.0 8.3 6.8 5.9 7.4 1.5 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein Cep57_MT_bd PF06657.13 EXF74585.1 - 6.4 7.3 18.7 1.2 9.7 2.5 3.4 1 1 1 3 3 3 0 Centrosome microtubule-binding domain of Cep57 YabA PF06156.13 EXF74585.1 - 6.5 7.4 21.6 62 4.3 0.4 3.1 1 1 1 2 2 1 0 Initiation control protein YabA BST2 PF16716.5 EXF74585.1 - 7.8 7.2 25.3 7.3 7.3 8.8 3.5 1 1 2 3 3 3 0 Bone marrow stromal antigen 2 OmpH PF03938.14 EXF74585.1 - 8.4 6.7 32.1 7.5 6.9 17.4 2.6 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) SlyX PF04102.12 EXF74585.1 - 8.5 7.1 21.1 0.79 10.4 1.8 3.8 1 1 4 5 5 5 0 SlyX DUF812 PF05667.11 EXF74585.1 - 8.7 5.1 26.0 17 4.1 26.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF812) KxDL PF10241.9 EXF74585.1 - 9 6.6 15.0 2.1 8.7 2.2 3.5 1 1 3 4 4 4 0 Uncharacterized conserved protein N-SET PF11764.8 EXF74587.1 - 2.6e-46 157.9 1.0 2.6e-46 157.9 1.0 2.5 2 0 0 2 2 2 1 COMPASS (Complex proteins associated with Set1p) component N SET_assoc PF11767.8 EXF74587.1 - 3.8e-26 90.5 3.2 3.9e-26 90.5 0.7 2.5 3 0 0 3 3 3 1 Histone lysine methyltransferase SET associated SET PF00856.28 EXF74587.1 - 1.5e-18 67.8 0.2 1.5e-18 67.8 0.2 3.2 2 2 0 2 2 2 1 SET domain RRM_1 PF00076.22 EXF74587.1 - 0.012 15.4 0.2 2.3 8.1 0.0 2.9 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Cupin_8 PF13621.6 EXF74588.1 - 8.5e-70 235.4 0.2 9.9e-70 235.1 0.2 1.0 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 EXF74588.1 - 1.4e-06 28.0 0.0 0.00039 20.0 0.1 2.3 2 0 0 2 2 2 2 Cupin superfamily protein JmjC PF02373.22 EXF74588.1 - 0.1 13.1 0.1 1 9.8 0.0 2.5 2 1 0 3 3 3 0 JmjC domain, hydroxylase Sterol-sensing PF12349.8 EXF74589.1 - 2.9e-37 127.9 10.1 5e-37 127.1 10.1 1.4 1 0 0 1 1 1 1 Sterol-sensing domain of SREBP cleavage-activation Patched PF02460.18 EXF74589.1 - 3.7e-11 41.9 5.7 5.3e-11 41.4 5.7 1.1 1 0 0 1 1 1 1 Patched family WD40 PF00400.32 EXF74589.1 - 0.019 15.8 0.2 1.6 9.8 0.1 3.3 2 0 0 2 2 2 0 WD domain, G-beta repeat MMPL PF03176.15 EXF74589.1 - 0.022 13.7 0.1 0.022 13.7 0.1 1.6 2 0 0 2 2 2 0 MMPL family zinc_ribbon_10 PF10058.9 EXF74591.1 - 2e-20 72.3 0.3 4.1e-20 71.3 0.1 1.7 2 0 0 2 2 2 1 Predicted integral membrane zinc-ribbon metal-binding protein GRIP PF01465.20 EXF74592.1 - 1.2e-15 57.2 0.1 3e-15 55.9 0.1 1.8 1 0 0 1 1 1 1 GRIP domain CENP-F_leu_zip PF10473.9 EXF74592.1 - 4.3e-07 30.0 179.4 0.008 16.2 28.9 9.5 3 2 7 10 10 10 7 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Phage_GP20 PF06810.11 EXF74592.1 - 1.4e-06 28.2 162.4 0.0029 17.4 9.5 11.7 4 2 7 13 13 12 6 Phage minor structural protein GP20 HOOK PF05622.12 EXF74592.1 - 0.0001 20.6 150.0 0.1 10.7 1.7 4.6 3 1 1 4 4 4 4 HOOK protein DUF3584 PF12128.8 EXF74592.1 - 0.00077 17.1 28.4 0.00077 17.1 28.4 5.3 3 1 2 5 5 5 2 Protein of unknown function (DUF3584) Sec2p PF06428.11 EXF74592.1 - 0.0014 18.6 11.0 0.0014 18.6 11.0 12.3 8 3 2 10 10 8 1 GDP/GTP exchange factor Sec2p Spc7 PF08317.11 EXF74592.1 - 0.0026 16.7 168.3 0.11 11.3 23.1 7.6 3 3 4 7 7 7 6 Spc7 kinetochore protein DHR10 PF18595.1 EXF74592.1 - 0.0032 17.5 12.4 0.0032 17.5 12.4 11.4 5 2 3 11 11 10 4 Designed helical repeat protein 10 domain Cep57_CLD_2 PF14197.6 EXF74592.1 - 0.0032 17.5 1.1 0.0032 17.5 1.1 13.6 5 4 4 10 10 6 2 Centrosome localisation domain of PPC89 GAS PF13851.6 EXF74592.1 - 0.0039 16.6 169.8 0.027 13.8 13.9 9.4 3 3 7 10 10 10 5 Growth-arrest specific micro-tubule binding Leu_zip PF15294.6 EXF74592.1 - 0.0064 16.0 27.5 0.0064 16.0 27.5 7.1 2 2 1 6 6 6 3 Leucine zipper DUF4200 PF13863.6 EXF74592.1 - 0.0069 16.8 26.5 0.0069 16.8 26.5 11.4 6 2 6 13 13 11 2 Domain of unknown function (DUF4200) Filament PF00038.21 EXF74592.1 - 0.0077 15.9 150.0 0.077 12.6 19.8 9.5 3 2 5 8 8 8 4 Intermediate filament protein Nup54 PF13874.6 EXF74592.1 - 0.011 15.8 9.9 0.011 15.8 9.9 9.1 4 3 3 7 7 6 0 Nucleoporin complex subunit 54 NPV_P10 PF05531.12 EXF74592.1 - 0.2 12.2 71.2 0.99 9.9 1.4 10.9 8 2 2 10 10 10 0 Nucleopolyhedrovirus P10 protein MscS_porin PF12795.7 EXF74592.1 - 1.3 8.5 154.0 1.7 8.1 18.0 7.9 4 2 3 7 7 7 0 Mechanosensitive ion channel porin domain FPP PF05911.11 EXF74592.1 - 2 6.5 150.3 0.052 11.7 23.5 6.8 2 1 5 7 7 7 0 Filament-like plant protein, long coiled-coil MAD PF05557.13 EXF74592.1 - 5.5 5.2 162.3 0.026 12.9 34.3 5.7 3 2 3 6 6 6 0 Mitotic checkpoint protein TPR_MLP1_2 PF07926.12 EXF74592.1 - 9.1 6.4 181.8 0.025 14.6 13.8 10.9 3 3 7 10 10 10 0 TPR/MLP1/MLP2-like protein adh_short PF00106.25 EXF74593.1 - 2.1e-44 151.3 0.9 2.9e-44 150.9 0.9 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF74593.1 - 1.4e-41 142.6 0.5 2.8e-41 141.6 0.5 1.4 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF74593.1 - 1.7e-08 34.6 1.0 5.1e-08 33.0 0.9 1.9 1 1 0 1 1 1 1 KR domain ADH_zinc_N PF00107.26 EXF74593.1 - 0.0048 16.9 0.0 0.0088 16.0 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase NAD_binding_7 PF13241.6 EXF74593.1 - 0.017 15.5 1.3 0.045 14.2 0.3 2.3 2 2 1 3 3 3 0 Putative NAD(P)-binding F420_oxidored PF03807.17 EXF74593.1 - 0.026 15.1 0.1 0.067 13.8 0.1 1.8 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Epimerase PF01370.21 EXF74593.1 - 0.04 13.4 0.3 0.21 11.0 0.3 2.0 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Shikimate_DH PF01488.20 EXF74593.1 - 0.11 12.6 0.1 0.25 11.4 0.0 1.7 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase AdoHcyase_NAD PF00670.21 EXF74593.1 - 0.18 11.9 0.9 0.34 11.0 0.9 1.5 1 1 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain ETS_PEA3_N PF04621.13 EXF74594.1 - 0.0099 15.8 0.1 0.023 14.6 0.1 1.5 1 0 0 1 1 1 1 PEA3 subfamily ETS-domain transcription factor N terminal domain bZIP_1 PF00170.21 EXF74594.1 - 0.047 13.8 4.3 0.097 12.8 4.3 1.5 1 0 0 1 1 1 0 bZIP transcription factor bZIP_2 PF07716.15 EXF74594.1 - 0.19 11.8 5.7 0.66 10.1 5.7 1.9 1 1 0 1 1 1 0 Basic region leucine zipper Methyltransf_23 PF13489.6 EXF74595.1 - 5.4e-20 71.9 0.0 8.9e-20 71.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF74595.1 - 2.2e-12 47.0 0.0 7.8e-11 42.0 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF74595.1 - 9e-11 42.3 0.0 2.5e-10 40.9 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF74595.1 - 1.6e-07 31.9 0.0 3.4e-07 30.8 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF74595.1 - 4e-07 30.7 0.0 3.8e-06 27.6 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EXF74595.1 - 0.00045 19.8 0.0 0.0062 16.1 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase small domain CheR PF01739.18 EXF74595.1 - 0.0063 16.0 0.0 0.011 15.2 0.0 1.3 1 0 0 1 1 1 1 CheR methyltransferase, SAM binding domain Methyltransf_4 PF02390.17 EXF74595.1 - 0.014 14.9 0.0 0.032 13.7 0.0 1.6 2 0 0 2 2 2 0 Putative methyltransferase FtsJ PF01728.19 EXF74595.1 - 0.019 15.1 0.0 0.026 14.6 0.0 1.2 1 0 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_16 PF10294.9 EXF74595.1 - 0.063 13.0 0.0 0.095 12.4 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase PrmA PF06325.13 EXF74595.1 - 0.08 12.3 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Ubie_methyltran PF01209.18 EXF74595.1 - 0.13 11.6 0.0 8.2 5.7 0.0 2.3 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family TGS PF02824.21 EXF74595.1 - 0.17 12.0 0.0 21 5.3 0.0 2.3 2 0 0 2 2 2 0 TGS domain FAD_binding_3 PF01494.19 EXF74597.1 - 3.3e-74 250.2 0.0 4e-74 250.0 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 EXF74597.1 - 1e-08 35.2 0.1 0.0046 16.6 0.0 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EXF74597.1 - 0.0038 16.5 0.0 0.011 15.0 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EXF74597.1 - 0.0088 15.3 0.0 0.031 13.5 0.0 1.7 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EXF74597.1 - 0.012 15.9 0.0 0.036 14.3 0.0 1.9 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 EXF74597.1 - 0.02 14.2 0.0 0.032 13.5 0.0 1.3 1 0 0 1 1 1 0 Thi4 family Lycopene_cycl PF05834.12 EXF74597.1 - 0.027 13.5 0.0 0.064 12.3 0.0 1.6 1 0 0 1 1 1 0 Lycopene cyclase protein FAD_binding_2 PF00890.24 EXF74597.1 - 0.062 12.4 0.0 0.1 11.7 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain HI0933_like PF03486.14 EXF74597.1 - 0.076 11.7 0.0 0.15 10.8 0.0 1.5 1 0 0 1 1 1 0 HI0933-like protein Sugar_tr PF00083.24 EXF74598.1 - 1.2e-74 251.8 20.5 1.6e-49 169.0 3.8 2.0 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 EXF74598.1 - 6.4e-10 38.5 23.4 2.2e-09 36.7 23.5 1.7 1 1 0 1 1 1 1 Major Facilitator Superfamily TPR_19 PF14559.6 EXF74598.1 - 0.14 12.6 0.1 0.24 12.0 0.1 1.3 1 0 0 1 1 1 0 Tetratricopeptide repeat MPC PF03650.13 EXF74600.1 - 3.1e-47 159.3 0.6 3.1e-47 159.3 0.6 1.6 2 0 0 2 2 2 1 Mitochondrial pyruvate carriers L51_S25_CI-B8 PF05047.16 EXF74601.1 - 5e-12 45.6 0.0 9e-12 44.7 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain PAM2 PF07145.15 EXF74602.1 - 0.051 13.3 0.1 0.14 11.9 0.1 1.8 1 0 0 1 1 1 0 Ataxin-2 C-terminal region DUF1687 PF07955.11 EXF74603.1 - 1.5e-33 116.0 0.3 1.9e-33 115.6 0.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1687) CBP PF12192.8 EXF74603.1 - 0.012 15.7 0.2 0.41 10.9 0.0 2.2 2 0 0 2 2 2 0 Fungal calcium binding protein ArsC PF03960.15 EXF74603.1 - 0.069 13.2 0.0 0.14 12.2 0.0 1.5 1 0 0 1 1 1 0 ArsC family Ribosomal_L14e PF01929.17 EXF74605.1 - 4e-29 100.9 2.9 5.5e-29 100.5 2.9 1.2 1 0 0 1 1 1 1 Ribosomal protein L14 KOW PF00467.29 EXF74605.1 - 0.0001 22.1 1.3 0.00029 20.7 0.0 2.4 3 0 0 3 3 3 1 KOW motif NAC PF01849.18 EXF74606.1 - 5.9e-23 80.6 0.2 2.1e-22 78.8 0.0 2.0 2 0 0 2 2 2 1 NAC domain Myc_N PF01056.18 EXF74606.1 - 7.6 6.3 12.2 9.1 6.1 11.3 1.6 1 1 0 1 1 1 0 Myc amino-terminal region Mt_ATP-synt_D PF05873.12 EXF74607.1 - 2.2e-22 79.5 2.3 2.7e-22 79.3 2.3 1.1 1 0 0 1 1 1 1 ATP synthase D chain, mitochondrial (ATP5H) GIDA_assoc PF13932.6 EXF74607.1 - 0.063 13.5 1.2 0.083 13.1 1.2 1.2 1 0 0 1 1 1 0 GidA associated domain T5orf172 PF10544.9 EXF74607.1 - 0.088 13.4 0.3 0.29 11.7 0.3 1.9 1 1 0 1 1 1 0 T5orf172 domain DUF148 PF02520.17 EXF74607.1 - 0.88 9.7 6.4 0.35 11.0 2.7 2.0 1 1 1 2 2 2 0 Domain of unknown function DUF148 Abhydrolase_3 PF07859.13 EXF74608.1 - 2.7e-33 115.6 0.1 4.1e-33 115.0 0.1 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EXF74608.1 - 0.00062 19.1 0.0 0.00085 18.6 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EXF74608.1 - 0.00075 20.2 5.5 0.00075 20.2 5.5 1.7 1 1 1 2 2 2 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 EXF74608.1 - 0.059 12.8 0.0 0.097 12.1 0.0 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family DUF2920 PF11144.8 EXF74608.1 - 0.24 10.6 0.0 0.36 10.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2920) VPS28 PF03997.12 EXF74609.1 - 0.016 14.9 0.0 0.022 14.4 0.0 1.2 1 0 0 1 1 1 0 VPS28 protein PuR_N PF09182.10 EXF74609.1 - 0.13 12.2 0.2 0.41 10.6 0.0 1.8 2 0 0 2 2 2 0 Bacterial purine repressor, N-terminal MFS_1 PF07690.16 EXF74611.1 - 1.2e-36 126.3 24.1 1.2e-36 126.3 24.1 2.8 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF74611.1 - 3.5e-12 45.9 12.7 3.5e-12 45.9 12.7 2.8 2 1 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 EXF74611.1 - 0.00078 18.0 2.5 0.00078 18.0 2.5 1.5 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Thioredoxin PF00085.20 EXF74612.1 - 1.9e-06 27.8 0.0 2.8e-06 27.2 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_9 PF14595.6 EXF74612.1 - 0.013 15.3 0.0 0.13 12.1 0.0 2.0 2 0 0 2 2 2 0 Thioredoxin Redoxin PF08534.10 EXF74612.1 - 0.019 14.6 0.0 0.023 14.4 0.0 1.2 1 0 0 1 1 1 0 Redoxin DUF953 PF06110.11 EXF74612.1 - 0.023 14.3 0.4 0.24 11.0 0.4 2.0 1 1 0 1 1 1 0 Eukaryotic protein of unknown function (DUF953) Thioredoxin_2 PF13098.6 EXF74612.1 - 0.17 12.3 0.0 23 5.5 0.0 2.3 2 0 0 2 2 2 0 Thioredoxin-like domain rhaM PF05336.13 EXF74613.1 - 2.4e-36 124.1 1.0 2.8e-36 123.8 1.0 1.1 1 0 0 1 1 1 1 L-rhamnose mutarotase Amidohydro_2 PF04909.14 EXF74614.1 - 1.1e-42 146.9 2.3 1.3e-42 146.6 2.3 1.1 1 0 0 1 1 1 1 Amidohydrolase zf-RING_2 PF13639.6 EXF74616.1 - 1.4e-12 47.7 5.1 2.3e-12 47.1 5.1 1.3 1 0 0 1 1 1 1 Ring finger domain PA PF02225.22 EXF74616.1 - 3.4e-10 39.8 0.0 9.3e-10 38.4 0.0 1.8 1 0 0 1 1 1 1 PA domain zf-C3HC4_2 PF13923.6 EXF74616.1 - 2.4e-09 36.9 3.9 3.7e-09 36.3 3.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EXF74616.1 - 6.8e-09 35.9 2.1 1.3e-08 34.9 2.1 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 EXF74616.1 - 1.3e-08 34.6 3.1 2e-08 33.9 3.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EXF74616.1 - 3.3e-08 33.1 2.2 3.3e-08 33.1 2.2 1.8 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_5 PF14634.6 EXF74616.1 - 6e-07 29.3 2.4 9.3e-07 28.7 2.4 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EXF74616.1 - 5e-06 26.4 1.6 5e-05 23.3 2.3 2.2 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EXF74616.1 - 9.4e-06 25.4 2.9 1.4e-05 24.8 2.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EXF74616.1 - 0.0014 18.7 1.0 0.0025 17.8 1.0 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 EXF74616.1 - 0.0064 16.3 2.6 0.011 15.6 2.6 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 EXF74616.1 - 0.048 13.8 3.5 0.16 12.1 3.6 1.8 1 1 1 2 2 2 0 zinc finger of C3HC4-type, RING Zn_ribbon_17 PF17120.5 EXF74616.1 - 0.065 12.9 3.0 0.12 12.0 3.0 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type FANCL_C PF11793.8 EXF74616.1 - 0.1 12.8 2.4 0.25 11.5 2.4 1.7 1 1 0 1 1 1 0 FANCL C-terminal domain RINGv PF12906.7 EXF74616.1 - 0.21 11.7 2.6 0.43 10.7 2.6 1.6 1 1 0 1 1 1 0 RING-variant domain zf-Nse PF11789.8 EXF74616.1 - 1 9.2 2.5 1.9 8.4 2.5 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit PHD PF00628.29 EXF74616.1 - 1.1 9.2 2.4 1.9 8.4 2.4 1.4 1 0 0 1 1 1 0 PHD-finger zf-RING-like PF08746.11 EXF74616.1 - 1.3 9.4 3.2 2.2 8.7 3.2 1.4 1 0 0 1 1 1 0 RING-like domain DUF4083 PF13314.6 EXF74616.1 - 8.8 6.4 6.4 17 5.5 0.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4083) Y_phosphatase PF00102.27 EXF74617.1 - 2.9e-47 161.2 0.0 5.2e-47 160.4 0.0 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 EXF74617.1 - 0.0052 16.9 0.0 0.012 15.7 0.0 1.6 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 EXF74617.1 - 0.0072 16.3 0.0 0.011 15.8 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 EXF74617.1 - 0.015 15.1 0.0 0.026 14.3 0.0 1.4 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain RCC1 PF00415.18 EXF74618.1 - 7.6e-32 109.7 6.6 2.5e-10 40.8 0.0 8.1 7 2 0 7 7 7 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EXF74618.1 - 9.6e-20 69.9 17.0 2.3e-10 40.0 0.0 7.1 7 0 0 7 7 7 5 Regulator of chromosome condensation (RCC1) repeat Sec34 PF04136.15 EXF74619.1 - 2.1e-50 170.5 2.0 7.5e-50 168.7 2.0 2.0 1 0 0 1 1 1 1 Sec34-like family Ku_C PF03730.14 EXF74619.1 - 3.3 8.5 5.2 3.4 8.4 0.2 3.2 3 0 0 3 3 3 0 Ku70/Ku80 C-terminal arm Pkinase PF00069.25 EXF74620.1 - 2.6e-20 72.9 0.1 8.3e-20 71.3 0.1 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF74620.1 - 3.7e-14 52.6 0.0 2.4e-08 33.6 0.0 2.5 1 1 1 2 2 2 2 Protein tyrosine kinase CENP-H PF05837.12 EXF74620.1 - 7.8 7.0 6.6 6.1 7.3 4.5 1.9 2 0 0 2 2 2 0 Centromere protein H (CENP-H) ATG16 PF08614.11 EXF74622.1 - 2.5e-05 24.6 3.8 5e-05 23.6 3.8 1.4 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) DivIC PF04977.15 EXF74622.1 - 0.00061 19.5 3.5 0.0018 18.0 3.5 1.7 1 0 0 1 1 1 1 Septum formation initiator ADIP PF11559.8 EXF74622.1 - 0.0024 18.0 3.2 0.0046 17.1 3.2 1.4 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding SHE3 PF17078.5 EXF74622.1 - 0.0036 17.0 3.1 0.0054 16.5 3.1 1.2 1 0 0 1 1 1 1 SWI5-dependent HO expression protein 3 Jnk-SapK_ap_N PF09744.9 EXF74622.1 - 0.0041 17.4 4.3 0.0069 16.6 4.3 1.3 1 0 0 1 1 1 1 JNK_SAPK-associated protein-1 DUF4407 PF14362.6 EXF74622.1 - 0.02 14.2 1.8 0.032 13.6 1.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Mod_r PF07200.13 EXF74622.1 - 0.053 13.6 4.4 0.11 12.6 4.4 1.5 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein Rx_N PF18052.1 EXF74622.1 - 0.094 13.0 0.9 0.2 11.9 0.9 1.6 1 0 0 1 1 1 0 Rx N-terminal domain SF1-HH PF16275.5 EXF74622.1 - 0.16 12.3 2.8 1.8 8.9 0.2 2.7 2 0 0 2 2 2 0 Splicing factor 1 helix-hairpin domain Tropomyosin_1 PF12718.7 EXF74622.1 - 0.45 10.7 8.3 0.18 11.9 2.7 2.2 1 1 1 2 2 2 0 Tropomyosin like Csm1_N PF18504.1 EXF74622.1 - 0.48 10.8 5.0 1.1 9.7 5.0 1.6 1 0 0 1 1 1 0 Csm1 N-terminal domain WD40_alt PF14077.6 EXF74622.1 - 0.64 9.9 2.4 21 5.1 0.9 2.5 2 0 0 2 2 2 0 Alternative WD40 repeat motif SlyX PF04102.12 EXF74622.1 - 0.72 10.5 9.1 2.5 8.8 8.2 2.4 1 1 1 2 2 2 0 SlyX Alpha_L_fucos PF01120.17 EXF74623.1 - 8e-30 104.5 0.4 1.2e-29 103.9 0.4 1.1 1 0 0 1 1 1 1 Alpha-L-fucosidase F5_F8_type_C PF00754.25 EXF74623.1 - 4.8e-10 39.6 4.1 1.5e-09 38.0 0.0 3.0 3 1 1 4 4 4 1 F5/8 type C domain SGL PF08450.12 EXF74624.1 - 5.9e-24 85.0 0.3 1.4e-23 83.8 0.3 1.5 1 1 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Str_synth PF03088.16 EXF74624.1 - 0.00057 20.0 0.0 0.0035 17.4 0.0 2.1 1 1 0 1 1 1 1 Strictosidine synthase Arylesterase PF01731.20 EXF74624.1 - 0.04 14.1 0.0 0.25 11.6 0.0 2.3 1 1 1 2 2 2 0 Arylesterase NHL PF01436.21 EXF74624.1 - 0.06 13.4 0.1 6.2 7.1 0.0 2.9 2 0 0 2 2 2 0 NHL repeat Glyco_hydro_43 PF04616.14 EXF74626.1 - 4.4e-22 78.7 0.3 1e-16 61.1 0.1 2.0 1 1 1 2 2 2 2 Glycosyl hydrolases family 43 CFEM PF05730.11 EXF74628.1 - 9.3e-10 38.5 8.2 2e-09 37.4 8.2 1.6 1 0 0 1 1 1 1 CFEM domain Sugar_tr PF00083.24 EXF74629.1 - 5.4e-95 318.9 19.9 5.4e-95 318.9 19.9 1.5 1 1 1 2 2 2 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF74629.1 - 7.4e-22 77.7 27.8 5.3e-20 71.7 9.3 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily YbhQ PF11076.8 EXF74629.1 - 0.054 13.5 0.1 0.12 12.3 0.1 1.6 1 0 0 1 1 1 0 Putative inner membrane protein YbhQ DUF4234 PF14018.6 EXF74629.1 - 0.12 12.5 1.9 0.86 9.8 0.2 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4234) adh_short PF00106.25 EXF74630.1 - 2.2e-43 148.0 0.1 2.8e-43 147.6 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF74630.1 - 9.9e-39 133.3 0.5 1.8e-38 132.4 0.5 1.4 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF74630.1 - 2.9e-07 30.6 0.4 2.3e-06 27.7 0.3 1.9 1 1 1 2 2 2 1 KR domain Epimerase PF01370.21 EXF74630.1 - 0.00011 21.8 0.0 0.00022 20.8 0.0 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EXF74630.1 - 0.00037 20.4 0.7 0.011 15.7 0.7 2.2 1 1 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 EXF74630.1 - 0.0052 16.2 0.0 0.0075 15.7 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 EXF74630.1 - 0.009 15.2 0.0 0.013 14.7 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein 3HCDH_N PF02737.18 EXF74630.1 - 0.022 14.6 0.0 0.25 11.2 0.0 2.1 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Ldh_1_N PF00056.23 EXF74630.1 - 0.025 14.7 0.0 0.17 12.0 0.1 2.2 2 0 0 2 2 2 0 lactate/malate dehydrogenase, NAD binding domain NmrA PF05368.13 EXF74630.1 - 0.065 12.8 0.1 0.18 11.4 0.1 1.8 2 0 0 2 2 2 0 NmrA-like family Copine PF07002.16 EXF74630.1 - 0.15 11.5 0.0 0.24 10.8 0.0 1.4 1 0 0 1 1 1 0 Copine RmlD_sub_bind PF04321.17 EXF74630.1 - 0.17 11.0 0.2 0.31 10.1 0.2 1.4 1 1 0 1 1 1 0 RmlD substrate binding domain Neur_chan_memb PF02932.16 EXF74631.1 - 0.47 10.5 1.6 14 5.7 0.1 2.3 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region MHB PF16525.5 EXF74631.1 - 0.92 9.8 6.8 3 8.1 6.8 1.8 1 0 0 1 1 1 0 Haemophore, haem-binding RP-C_C PF11800.8 EXF74631.1 - 1.2 9.2 6.1 0.14 12.3 0.4 2.1 2 0 0 2 2 2 0 Replication protein C C-terminal region TMEM247 PF15444.6 EXF74632.1 - 0.055 13.5 0.7 0.069 13.2 0.7 1.1 1 0 0 1 1 1 0 Transmembrane protein 247 LPMO_10 PF03067.15 EXF74632.1 - 0.12 13.1 0.3 0.16 12.7 0.3 1.2 1 0 0 1 1 1 0 Lytic polysaccharide mono-oxygenase, cellulose-degrading FAD_binding_1 PF00667.20 EXF74634.1 - 9.8e-45 152.8 0.0 1.4e-44 152.3 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.21 EXF74634.1 - 3.2e-09 37.4 0.0 1e-08 35.8 0.0 1.9 1 1 0 1 1 1 1 Oxidoreductase NAD-binding domain Nitroreductase PF00881.24 EXF74635.1 - 1e-15 58.2 0.0 1.2e-15 58.0 0.0 1.1 1 0 0 1 1 1 1 Nitroreductase family PS_Dcarbxylase PF02666.15 EXF74636.1 - 7.6e-77 257.4 0.0 2.1e-76 255.9 0.0 1.6 1 1 0 1 1 1 1 Phosphatidylserine decarboxylase Cyt_b-c1_8 PF10890.8 EXF74636.1 - 0.097 13.1 0.1 2.7 8.5 0.0 2.4 2 0 0 2 2 2 0 Cytochrome b-c1 complex subunit 8 Biotin_lipoyl PF00364.22 EXF74636.1 - 0.099 12.5 0.0 0.23 11.3 0.0 1.6 1 0 0 1 1 1 0 Biotin-requiring enzyme ubiquitin PF00240.23 EXF74637.1 - 4e-07 29.7 0.0 1e-06 28.4 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin family DUF2407 PF10302.9 EXF74637.1 - 0.00019 22.0 1.7 0.00032 21.2 0.1 2.2 2 0 0 2 2 2 1 DUF2407 ubiquitin-like domain Rad60-SLD PF11976.8 EXF74637.1 - 0.083 12.7 0.0 0.22 11.4 0.0 1.6 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Striatin PF08232.12 EXF74637.1 - 5.9 7.5 11.9 3.1 8.4 8.4 2.2 2 0 0 2 2 2 0 Striatin family zf-CCCH_4 PF18044.1 EXF74638.1 - 0.00031 20.5 3.4 0.00031 20.5 3.4 2.8 2 1 0 2 2 2 1 CCCH-type zinc finger zf-CCCH_2 PF14608.6 EXF74638.1 - 0.0015 18.9 4.3 0.0015 18.9 4.3 2.4 2 0 0 2 2 2 1 RNA-binding, Nab2-type zinc finger ORC6 PF05460.13 EXF74638.1 - 7.9 5.6 10.0 12 5.0 10.0 1.2 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) SPRY PF00622.28 EXF74639.1 - 2.6e-20 72.7 0.0 5e-20 71.8 0.0 1.5 1 0 0 1 1 1 1 SPRY domain adh_short PF00106.25 EXF74641.1 - 8.5e-23 80.8 0.4 6e-17 61.7 0.0 2.1 1 1 1 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EXF74641.1 - 8e-11 41.9 0.0 1.9e-09 37.4 0.0 2.1 1 1 1 2 2 2 1 Enoyl-(Acyl carrier protein) reductase 3HCDH_N PF02737.18 EXF74641.1 - 0.038 13.9 0.2 0.2 11.5 0.0 2.0 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GFA PF04828.14 EXF74642.1 - 5e-22 78.0 0.9 7.3e-22 77.5 0.9 1.2 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme FAD_binding_3 PF01494.19 EXF74643.1 - 5.8e-33 114.6 0.0 1.3e-32 113.4 0.0 1.6 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.6 EXF74643.1 - 4.6e-07 29.4 0.2 6.1e-06 25.7 0.2 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EXF74643.1 - 1.1e-06 28.8 0.2 3.6e-06 27.1 0.2 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 EXF74643.1 - 4.9e-06 26.1 0.0 0.0051 16.1 0.0 2.2 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase FAD_oxidored PF12831.7 EXF74643.1 - 6.2e-06 25.8 0.5 4.3e-05 23.1 0.2 2.3 1 1 1 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EXF74643.1 - 2.5e-05 23.7 0.0 0.00062 19.1 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EXF74643.1 - 5.1e-05 23.0 0.9 0.0037 16.9 1.1 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 EXF74643.1 - 5.4e-05 23.7 0.6 0.00059 20.3 0.4 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EXF74643.1 - 6.9e-05 22.2 0.2 0.0003 20.1 0.1 1.9 2 0 0 2 2 2 1 Thi4 family HI0933_like PF03486.14 EXF74643.1 - 0.00012 21.0 0.1 0.0012 17.6 0.1 2.0 2 0 0 2 2 2 1 HI0933-like protein Lycopene_cycl PF05834.12 EXF74643.1 - 0.00014 21.1 0.1 0.18 10.8 0.1 2.1 2 0 0 2 2 2 2 Lycopene cyclase protein Trp_halogenase PF04820.14 EXF74643.1 - 0.00032 19.7 0.1 0.00058 18.8 0.1 1.4 1 0 0 1 1 1 1 Tryptophan halogenase FAD_binding_2 PF00890.24 EXF74643.1 - 0.0011 18.1 0.2 0.0017 17.5 0.2 1.3 1 0 0 1 1 1 1 FAD binding domain GIDA PF01134.22 EXF74643.1 - 0.0072 15.5 0.2 0.013 14.6 0.0 1.5 2 0 0 2 2 2 1 Glucose inhibited division protein A AlaDh_PNT_C PF01262.21 EXF74643.1 - 0.068 12.5 0.1 0.12 11.7 0.1 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain TrkA_N PF02254.18 EXF74643.1 - 0.14 12.4 0.2 0.32 11.3 0.2 1.6 1 0 0 1 1 1 0 TrkA-N domain Lipocalin_9 PF17186.4 EXF74644.1 - 1e-07 32.3 0.0 2.7e-07 30.9 0.0 1.6 1 0 0 1 1 1 1 Lipocalin-like domain CrtC PF07143.11 EXF74644.1 - 0.00014 22.6 0.5 0.00029 21.5 0.5 1.6 1 0 0 1 1 1 1 CrtC N-terminal lipocalin domain Methyltransf_23 PF13489.6 EXF74645.1 - 6.8e-23 81.3 0.0 1.2e-22 80.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF74645.1 - 3.9e-11 43.5 0.0 7.7e-11 42.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF74645.1 - 3.4e-08 34.0 0.0 5.8e-08 33.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF74645.1 - 1.2e-07 31.7 0.0 1.1e-06 28.5 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF74645.1 - 8e-07 29.7 0.0 3.6e-06 27.6 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 EXF74645.1 - 0.0055 16.2 0.0 0.013 15.0 0.0 1.5 1 0 0 1 1 1 1 Putative methyltransferase MTS PF05175.14 EXF74645.1 - 0.011 15.4 0.0 0.027 14.0 0.0 1.6 2 0 0 2 2 2 0 Methyltransferase small domain PrmA PF06325.13 EXF74645.1 - 0.11 11.8 0.1 0.22 10.9 0.1 1.4 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) CMAS PF02353.20 EXF74645.1 - 0.13 11.5 0.0 0.35 10.1 0.0 1.6 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase DUF834 PF05754.14 EXF74648.1 - 0.11 12.5 0.1 0.21 11.6 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF834) Zn_clus PF00172.18 EXF74649.1 - 6.7e-08 32.5 11.1 1.1e-07 31.9 11.1 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EXF74649.1 - 2.6e-07 29.8 0.3 4.4e-07 29.0 0.3 1.4 1 1 0 1 1 1 1 Fungal specific transcription factor domain DUF4452 PF14618.6 EXF74650.1 - 6.2e-82 273.5 10.3 7.3e-82 273.3 10.3 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4452) stn_TNFRSF12A PF12191.8 EXF74652.1 - 0.65 10.2 4.1 2.8 8.2 0.3 2.1 1 1 1 2 2 2 0 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain Hydrolase_4 PF12146.8 EXF74653.1 - 2.5e-10 40.1 0.0 1.3e-09 37.7 0.0 2.0 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EXF74653.1 - 7.4e-10 38.9 0.8 4.9e-09 36.2 1.5 2.0 2 1 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EXF74653.1 - 3e-09 37.8 16.5 4.4e-09 37.3 11.6 2.7 2 1 0 2 2 2 1 Alpha/beta hydrolase family Thioesterase PF00975.20 EXF74653.1 - 0.27 11.3 0.5 0.52 10.4 0.5 1.4 1 0 0 1 1 1 0 Thioesterase domain TauD PF02668.16 EXF74654.1 - 1.5e-29 103.7 0.1 2.4e-29 103.0 0.1 1.3 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Ank_2 PF12796.7 EXF74654.1 - 7.2e-24 84.2 0.2 2.9e-10 40.6 0.1 4.1 2 1 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EXF74654.1 - 7e-16 58.4 1.7 4.3e-07 30.4 0.1 5.2 3 1 3 6 6 6 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EXF74654.1 - 1.5e-15 55.7 3.7 0.15 12.7 0.0 7.4 7 0 0 7 7 7 4 Ankyrin repeat Ank_5 PF13857.6 EXF74654.1 - 4.7e-15 55.4 1.9 3.7e-05 23.9 0.0 5.2 4 1 0 5 5 5 2 Ankyrin repeats (many copies) Ank PF00023.30 EXF74654.1 - 1.6e-09 37.7 5.2 0.48 11.0 0.0 6.4 6 0 0 6 6 6 3 Ankyrin repeat ProRS-C_1 PF09180.11 EXF74654.1 - 0.11 12.8 0.0 1.1 9.5 0.0 2.3 2 0 0 2 2 2 0 Prolyl-tRNA synthetase, C-terminal MFS_1 PF07690.16 EXF74655.1 - 9.7e-29 100.4 35.5 9.7e-29 100.4 35.5 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily DUF898 PF05987.13 EXF74656.1 - 0.014 14.5 8.3 0.093 11.8 1.9 2.2 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF898) ATP_transf PF09830.9 EXF74657.1 - 1.2e-13 51.0 0.0 2e-13 50.3 0.0 1.4 1 0 0 1 1 1 1 ATP adenylyltransferase Hydantoinase_B PF02538.14 EXF74658.1 - 1.3e-198 660.6 0.0 1.9e-198 660.1 0.0 1.3 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Hydantoinase_A PF01968.18 EXF74658.1 - 5.2e-99 331.2 0.1 1e-98 330.2 0.1 1.5 1 0 0 1 1 1 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.13 EXF74658.1 - 3.4e-61 206.0 0.0 1.1e-59 201.1 0.0 2.4 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase N-terminal region MFS_1 PF07690.16 EXF74659.1 - 4.2e-23 81.8 29.4 4.2e-23 81.8 29.4 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily MFS_4 PF06779.14 EXF74659.1 - 0.00047 19.6 0.4 0.00047 19.6 0.4 2.2 2 0 0 2 2 2 2 Uncharacterised MFS-type transporter YbfB LapA_dom PF06305.11 EXF74659.1 - 0.092 12.6 0.4 2.3 8.1 0.0 2.9 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain DAO PF01266.24 EXF74660.1 - 2.6e-38 132.5 0.2 3.5e-38 132.1 0.2 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EXF74660.1 - 3.3e-07 30.4 0.0 8.5e-07 29.1 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EXF74660.1 - 5.1e-07 29.2 0.0 0.011 14.9 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EXF74660.1 - 6e-07 29.9 0.6 0.076 13.6 0.0 3.0 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EXF74660.1 - 6.7e-07 28.9 0.0 7.5e-05 22.1 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 EXF74660.1 - 2.2e-06 27.2 0.1 0.011 15.1 0.0 2.3 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase FAD_binding_2 PF00890.24 EXF74660.1 - 5.8e-06 25.6 0.4 0.0028 16.8 0.1 2.1 2 0 0 2 2 2 2 FAD binding domain HI0933_like PF03486.14 EXF74660.1 - 2.3e-05 23.3 0.6 0.023 13.4 0.1 2.3 2 0 0 2 2 2 2 HI0933-like protein GIDA PF01134.22 EXF74660.1 - 0.00014 21.1 0.5 0.38 9.8 0.0 2.3 2 0 0 2 2 2 2 Glucose inhibited division protein A Thi4 PF01946.17 EXF74660.1 - 0.00042 19.6 0.0 0.00072 18.9 0.0 1.3 1 0 0 1 1 1 1 Thi4 family FAD_binding_3 PF01494.19 EXF74660.1 - 0.0059 15.9 2.2 0.0095 15.2 0.1 2.5 3 1 0 3 3 3 1 FAD binding domain ThiF PF00899.21 EXF74660.1 - 0.011 15.1 0.1 0.041 13.2 0.0 1.9 2 1 0 2 2 2 0 ThiF family Shikimate_DH PF01488.20 EXF74660.1 - 0.027 14.5 0.0 0.05 13.7 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase NAD_binding_9 PF13454.6 EXF74660.1 - 0.046 13.7 0.1 9.9 6.1 0.0 2.5 2 0 0 2 2 2 0 FAD-NAD(P)-binding DUF685 PF05085.12 EXF74660.1 - 0.095 12.0 0.5 0.17 11.2 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF685) ApbA PF02558.16 EXF74660.1 - 0.17 11.5 0.0 0.36 10.5 0.0 1.6 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Cupin_1 PF00190.22 EXF74661.1 - 9.5e-16 57.8 1.0 9.5e-16 57.8 1.0 1.5 2 0 0 2 2 2 1 Cupin Cupin_2 PF07883.11 EXF74661.1 - 0.033 13.9 0.0 0.068 12.9 0.0 1.5 1 0 0 1 1 1 0 Cupin domain GMC_oxred_N PF00732.19 EXF74662.1 - 5.7e-53 180.2 0.0 7.3e-53 179.9 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EXF74662.1 - 3.5e-30 105.4 0.0 1.1e-29 103.7 0.0 1.8 2 0 0 2 2 2 1 GMC oxidoreductase Lycopene_cycl PF05834.12 EXF74662.1 - 3.6e-07 29.6 0.1 1.1e-05 24.6 0.0 2.1 2 0 0 2 2 2 1 Lycopene cyclase protein DAO PF01266.24 EXF74662.1 - 9.3e-06 25.4 1.3 3.2e-05 23.7 1.3 1.8 1 1 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.22 EXF74662.1 - 0.00053 19.2 0.1 0.54 9.3 0.0 2.1 2 0 0 2 2 2 2 Glucose inhibited division protein A FAD_binding_2 PF00890.24 EXF74662.1 - 0.00059 19.0 1.7 0.25 10.4 0.6 2.2 2 0 0 2 2 2 2 FAD binding domain Pyr_redox_2 PF07992.14 EXF74662.1 - 0.00066 19.0 0.0 0.23 10.6 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EXF74662.1 - 0.014 15.6 0.1 0.039 14.2 0.1 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 EXF74662.1 - 0.081 11.6 0.3 1.2 7.8 0.1 2.0 2 0 0 2 2 2 0 HI0933-like protein Pyr_redox_3 PF13738.6 EXF74662.1 - 0.13 11.5 0.0 7 5.8 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EXF74662.1 - 0.15 12.6 0.8 0.8 10.3 0.2 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EXF74662.1 - 0.22 11.5 0.5 11 5.9 0.1 2.4 2 0 0 2 2 2 0 FAD-NAD(P)-binding MFS_1 PF07690.16 EXF74663.1 - 8.2e-26 90.7 28.1 1.8e-25 89.7 25.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DAO PF01266.24 EXF74664.1 - 4.1e-40 138.4 0.0 4.8e-40 138.2 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EXF74664.1 - 7.2e-07 29.3 0.0 1.9e-06 28.0 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EXF74664.1 - 0.00019 20.7 0.0 0.003 16.9 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EXF74664.1 - 0.0011 18.2 0.1 0.019 14.0 0.1 2.1 1 1 0 1 1 1 1 FAD binding domain Shikimate_DH PF01488.20 EXF74664.1 - 0.0016 18.5 0.0 0.023 14.7 0.0 2.2 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase FAD_binding_3 PF01494.19 EXF74664.1 - 0.0046 16.2 0.0 0.0067 15.7 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.27 EXF74664.1 - 0.0063 17.1 0.1 0.023 15.2 0.0 2.0 2 0 0 2 2 1 1 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.18 EXF74664.1 - 0.02 15.2 0.0 0.067 13.5 0.0 1.8 2 0 0 2 2 2 0 TrkA-N domain GIDA PF01134.22 EXF74664.1 - 0.043 12.9 0.0 7.4 5.5 0.0 2.1 2 0 0 2 2 2 0 Glucose inhibited division protein A Trp_halogenase PF04820.14 EXF74664.1 - 0.064 12.1 0.1 7.4 5.3 0.0 2.1 2 0 0 2 2 2 0 Tryptophan halogenase ApbA PF02558.16 EXF74664.1 - 0.078 12.6 0.0 0.16 11.6 0.0 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Glu_dehyd_C PF16912.5 EXF74664.1 - 0.12 11.8 0.0 0.2 11.1 0.0 1.3 1 0 0 1 1 1 0 Glucose dehydrogenase C-terminus Sacchrp_dh_NADP PF03435.18 EXF74664.1 - 0.13 12.5 0.0 0.32 11.3 0.0 1.6 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain GMC_oxred_N PF00732.19 EXF74664.1 - 0.14 11.5 0.0 0.35 10.2 0.0 1.6 2 0 0 2 2 2 0 GMC oxidoreductase NAD_binding_7 PF13241.6 EXF74664.1 - 0.17 12.4 0.0 0.33 11.4 0.0 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding Pyr_redox_3 PF13738.6 EXF74664.1 - 0.23 10.7 0.0 0.48 9.6 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Fungal_trans PF04082.18 EXF74665.1 - 2.1e-10 40.1 0.0 4.5e-10 39.0 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF74665.1 - 0.046 13.9 1.9 0.1 12.7 1.9 1.6 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF1924 PF09086.11 EXF74665.1 - 0.089 13.2 0.3 0.27 11.6 0.3 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF1924) Fructosamin_kin PF03881.14 EXF74666.1 - 6.6e-32 110.9 0.0 8.6e-32 110.5 0.0 1.1 1 0 0 1 1 1 1 Fructosamine kinase APH PF01636.23 EXF74666.1 - 0.15 12.0 0.0 0.21 11.5 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family SF3b1 PF08920.10 EXF74666.1 - 0.19 12.2 0.0 0.36 11.4 0.0 1.4 1 0 0 1 1 1 0 Splicing factor 3B subunit 1 LtrA PF06772.11 EXF74667.1 - 3e-17 62.9 16.5 3e-17 62.9 16.5 2.6 2 1 0 2 2 2 2 Bacterial low temperature requirement A protein (LtrA) MFS_1 PF07690.16 EXF74668.1 - 1.5e-43 149.1 52.7 1.5e-43 149.1 52.7 1.7 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF74668.1 - 3e-13 49.4 37.6 2.5e-11 43.1 15.0 3.0 3 0 0 3 3 3 2 Sugar (and other) transporter TRI12 PF06609.13 EXF74668.1 - 8.9e-12 44.2 29.8 2.5e-11 42.7 29.8 1.6 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Peptidase_M3 PF01432.20 EXF74669.1 - 2.6e-118 396.2 0.0 1.4e-117 393.8 0.0 1.9 1 1 0 1 1 1 1 Peptidase family M3 TauD PF02668.16 EXF74670.1 - 2e-62 211.4 0.3 2.4e-62 211.2 0.3 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Sugar_tr PF00083.24 EXF74671.1 - 2.3e-128 428.9 27.9 2.7e-128 428.7 27.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF74671.1 - 9.4e-23 80.7 50.9 9.8e-18 64.2 26.6 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily GRDP-like PF07173.12 EXF74672.1 - 2.9e-14 53.9 0.7 6e-14 52.9 0.0 1.8 2 0 0 2 2 2 1 Glycine-rich domain-containing protein-like DUF1524 PF07510.11 EXF74673.1 - 1.2e-08 34.9 0.0 1.5e-08 34.6 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1524) Glyco_hydro_16 PF00722.21 EXF74674.1 - 5.1e-43 146.6 0.3 1e-42 145.6 0.3 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 Staphylcoagulse PF04022.12 EXF74674.1 - 0.37 10.4 4.9 1.1 8.8 4.9 1.8 1 0 0 1 1 1 0 Staphylocoagulase repeat SOG2 PF10428.9 EXF74674.1 - 1.4 8.1 9.1 1.7 7.7 9.1 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Mucin PF01456.17 EXF74674.1 - 8.5 6.4 24.8 23 5.0 24.8 1.7 1 0 0 1 1 1 0 Mucin-like glycoprotein AAA_18 PF13238.6 EXF74676.1 - 1.6e-12 48.1 0.2 1.2e-11 45.3 0.2 2.7 1 1 0 1 1 1 1 AAA domain SKI PF01202.22 EXF74676.1 - 2.2e-12 47.4 0.0 2.7e-12 47.1 0.0 1.1 1 0 0 1 1 1 1 Shikimate kinase AAA_33 PF13671.6 EXF74676.1 - 1.9e-10 41.0 0.0 2.4e-10 40.7 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 EXF74676.1 - 1.3e-05 25.6 0.0 2.7e-05 24.6 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EXF74676.1 - 1.9e-05 25.1 0.0 2.4e-05 24.8 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EXF74676.1 - 5.4e-05 23.5 0.1 0.00012 22.4 0.1 1.8 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 EXF74676.1 - 0.00013 22.4 0.0 0.00023 21.6 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.12 EXF74676.1 - 0.00017 20.9 0.0 0.00025 20.4 0.0 1.2 1 0 0 1 1 1 1 Zeta toxin CPT PF07931.12 EXF74676.1 - 0.00048 20.0 0.0 0.0037 17.1 0.0 2.0 1 1 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein APS_kinase PF01583.20 EXF74676.1 - 0.0011 18.9 0.0 0.0014 18.6 0.0 1.3 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_5 PF07728.14 EXF74676.1 - 0.0012 18.9 0.1 0.0036 17.3 0.1 1.9 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) ABC_tran PF00005.27 EXF74676.1 - 0.0022 18.5 0.0 0.0029 18.1 0.0 1.4 1 0 0 1 1 1 1 ABC transporter NTPase_1 PF03266.15 EXF74676.1 - 0.0025 17.8 0.5 0.0073 16.2 0.2 1.8 2 1 1 3 3 3 1 NTPase AAA_7 PF12775.7 EXF74676.1 - 0.0028 17.2 0.1 0.0045 16.5 0.1 1.2 1 0 0 1 1 1 1 P-loop containing dynein motor region Rad17 PF03215.15 EXF74676.1 - 0.0036 17.2 0.0 0.0063 16.5 0.0 1.5 2 0 0 2 2 1 1 Rad17 P-loop domain T2SSE PF00437.20 EXF74676.1 - 0.0044 16.1 0.1 0.0068 15.5 0.1 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein RNA_helicase PF00910.22 EXF74676.1 - 0.0047 17.3 0.0 0.0076 16.6 0.0 1.3 1 0 0 1 1 1 1 RNA helicase Sigma54_activ_2 PF14532.6 EXF74676.1 - 0.0047 17.0 0.0 0.013 15.6 0.0 1.7 1 0 0 1 1 1 1 Sigma-54 interaction domain PhoH PF02562.16 EXF74676.1 - 0.0059 16.1 0.1 0.0087 15.5 0.1 1.3 1 0 0 1 1 1 1 PhoH-like protein TsaE PF02367.17 EXF74676.1 - 0.0068 16.4 0.0 0.01 15.9 0.0 1.3 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_14 PF13173.6 EXF74676.1 - 0.007 16.4 0.0 0.02 14.9 0.0 1.9 1 1 0 1 1 1 1 AAA domain Cytidylate_kin PF02224.18 EXF74676.1 - 0.0081 15.9 0.0 0.01 15.6 0.0 1.2 1 0 0 1 1 1 1 Cytidylate kinase AAA_28 PF13521.6 EXF74676.1 - 0.0081 16.4 1.1 0.022 15.0 1.1 1.8 1 1 0 1 1 1 1 AAA domain CoaE PF01121.20 EXF74676.1 - 0.0085 15.8 0.0 0.012 15.3 0.0 1.4 1 0 0 1 1 1 1 Dephospho-CoA kinase NB-ARC PF00931.22 EXF74676.1 - 0.012 14.8 0.1 0.023 13.9 0.0 1.5 2 0 0 2 2 2 0 NB-ARC domain AAA_30 PF13604.6 EXF74676.1 - 0.012 15.3 0.0 0.021 14.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 EXF74676.1 - 0.012 15.0 0.0 0.019 14.3 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI dNK PF01712.19 EXF74676.1 - 0.025 14.4 0.1 0.49 10.2 0.0 2.2 1 1 1 2 2 2 0 Deoxynucleoside kinase AAA_23 PF13476.6 EXF74676.1 - 0.026 15.0 1.4 0.041 14.4 0.9 1.5 1 1 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 EXF74676.1 - 0.035 14.0 0.0 0.043 13.7 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_25 PF13481.6 EXF74676.1 - 0.043 13.4 0.2 0.088 12.4 0.1 1.5 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EXF74676.1 - 0.044 13.5 0.0 0.051 13.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 EXF74676.1 - 0.051 13.3 0.0 0.099 12.3 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain PIF1 PF05970.14 EXF74676.1 - 0.06 12.5 0.0 0.086 12.0 0.0 1.2 1 0 0 1 1 1 0 PIF1-like helicase ATPase PF06745.13 EXF74676.1 - 0.061 12.7 0.3 0.086 12.2 0.3 1.4 1 1 0 1 1 1 0 KaiC AAA_29 PF13555.6 EXF74676.1 - 0.061 13.1 0.1 0.11 12.3 0.1 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain RuvB_N PF05496.12 EXF74676.1 - 0.066 13.0 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_19 PF13245.6 EXF74676.1 - 0.068 13.5 0.0 0.15 12.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain Ploopntkinase3 PF18751.1 EXF74676.1 - 0.071 13.0 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 RsgA_GTPase PF03193.16 EXF74676.1 - 0.13 12.1 0.0 0.21 11.5 0.0 1.3 1 0 0 1 1 1 0 RsgA GTPase IstB_IS21 PF01695.17 EXF74676.1 - 0.15 11.8 0.0 0.29 10.8 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_11 PF13086.6 EXF74676.1 - 0.19 11.5 0.0 0.25 11.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain ResIII PF04851.15 EXF74676.1 - 0.19 11.7 0.2 0.43 10.6 0.2 1.5 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit cobW PF02492.19 EXF74676.1 - 0.21 11.2 0.0 0.32 10.6 0.0 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain Aldedh PF00171.22 EXF74677.1 - 2.6e-146 487.8 0.3 3.2e-146 487.5 0.3 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 EXF74677.1 - 0.0046 16.0 0.0 0.0076 15.3 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA reductase (LuxC) DUF1487 PF07368.11 EXF74677.1 - 0.009 15.5 0.0 4.3 6.7 0.0 2.8 3 0 0 3 3 3 2 Protein of unknown function (DUF1487) Transferase PF02458.15 EXF74678.1 - 1.5e-06 27.1 0.0 1.4e-05 24.0 0.0 2.2 2 1 0 2 2 2 1 Transferase family tRNA-synt_2 PF00152.20 EXF74679.1 - 1.4e-72 244.4 0.0 2.3e-72 243.7 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) DUF2156 PF09924.9 EXF74679.1 - 2.6e-14 52.9 0.1 3.8e-14 52.4 0.1 1.3 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2156) tRNA_anti-codon PF01336.25 EXF74679.1 - 2.5e-08 33.8 0.0 7e-08 32.3 0.0 1.8 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain Peptidase_S64 PF08192.11 EXF74679.1 - 0.36 9.3 5.7 0.29 9.6 3.8 1.6 2 0 0 2 2 2 0 Peptidase family S64 Abhydrolase_3 PF07859.13 EXF74680.1 - 6.4e-44 150.3 0.0 9.4e-44 149.8 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EXF74680.1 - 1.2e-05 26.0 0.7 1.2e-05 26.0 0.7 1.4 2 0 0 2 2 2 1 Alpha/beta hydrolase family COesterase PF00135.28 EXF74680.1 - 9.4e-05 21.5 0.0 0.00039 19.4 0.0 1.8 2 0 0 2 2 2 1 Carboxylesterase family Esterase PF00756.20 EXF74680.1 - 0.002 17.8 0.0 1.4 8.5 0.0 2.4 2 0 0 2 2 2 2 Putative esterase Peptidase_S9 PF00326.21 EXF74680.1 - 0.0032 17.0 0.0 0.013 15.0 0.0 2.0 1 1 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_2 PF02230.16 EXF74680.1 - 0.0083 15.9 0.0 0.022 14.5 0.0 1.6 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase AXE1 PF05448.12 EXF74680.1 - 0.12 11.0 0.0 3 6.4 0.0 2.1 2 0 0 2 2 2 0 Acetyl xylan esterase (AXE1) Methyltransf_23 PF13489.6 EXF74681.1 - 3.5e-19 69.2 0.0 5e-19 68.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF74681.1 - 6.4e-09 36.4 0.0 1.9e-07 31.7 0.0 2.6 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF74681.1 - 2.2e-07 31.4 0.0 2.1e-06 28.3 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF74681.1 - 5.1e-07 30.3 0.0 9.3e-06 26.3 0.1 2.7 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF74681.1 - 6.8e-07 29.2 0.0 0.0035 17.1 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain CheR PF01739.18 EXF74681.1 - 0.12 11.9 0.0 0.22 11.0 0.0 1.3 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain Ank_2 PF12796.7 EXF74682.1 - 2.6e-13 50.3 0.0 3.8e-13 49.8 0.0 1.2 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EXF74682.1 - 7.1e-11 42.4 0.4 4.9e-05 23.8 0.0 3.2 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 EXF74682.1 - 1.8e-10 40.9 0.4 5.4e-10 39.3 0.2 1.9 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 EXF74682.1 - 1.2e-09 38.2 0.2 4.2e-07 30.1 0.6 2.4 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.6 EXF74682.1 - 1.2e-09 37.5 0.0 4.8e-06 26.5 0.1 2.9 3 0 0 3 3 3 2 Ankyrin repeat Sec7 PF01369.20 EXF74683.1 - 8.1e-28 97.3 0.3 1.6e-27 96.3 0.1 1.5 2 0 0 2 2 2 1 Sec7 domain PH_9 PF15410.6 EXF74683.1 - 8.3e-18 64.9 0.0 1.8e-17 63.8 0.0 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain FAD_binding_3 PF01494.19 EXF74684.1 - 5.7e-47 160.6 0.0 8e-47 160.2 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 EXF74684.1 - 7.4e-07 29.1 1.2 0.0025 17.5 0.5 2.3 1 1 1 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EXF74684.1 - 0.0003 20.1 0.0 0.35 10.0 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EXF74684.1 - 0.0017 18.5 0.0 0.0044 17.2 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain SE PF08491.10 EXF74684.1 - 0.0035 16.4 0.0 0.055 12.5 0.0 2.0 2 0 0 2 2 2 1 Squalene epoxidase HI0933_like PF03486.14 EXF74684.1 - 0.02 13.6 0.0 0.037 12.7 0.0 1.4 2 0 0 2 2 2 0 HI0933-like protein Thi4 PF01946.17 EXF74684.1 - 0.15 11.3 0.0 0.25 10.5 0.0 1.4 1 0 0 1 1 1 0 Thi4 family UDPG_MGDP_dh_N PF03721.14 EXF74684.1 - 0.17 11.4 0.0 0.28 10.7 0.0 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Dioxygenase_C PF00775.21 EXF74685.1 - 2.6e-40 137.8 0.0 3.5e-40 137.4 0.0 1.2 1 0 0 1 1 1 1 Dioxygenase Dioxygenase_N PF04444.14 EXF74685.1 - 1.7e-28 98.3 0.0 2.9e-28 97.5 0.0 1.4 1 0 0 1 1 1 1 Catechol dioxygenase N terminus CarboxypepD_reg PF13620.6 EXF74685.1 - 0.00044 20.5 0.3 0.0011 19.2 0.3 1.6 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain Big_1 PF02369.16 EXF74685.1 - 0.077 13.0 0.0 0.16 12.0 0.0 1.5 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 1) GCV_T PF01571.21 EXF74686.1 - 5.8e-28 98.0 0.0 6.9e-28 97.7 0.0 1.0 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain DUF2434 PF10361.9 EXF74687.1 - 9.2e-133 441.7 6.6 1.2e-132 441.4 6.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2434) CitMHS PF03600.16 EXF74687.1 - 0.041 13.1 0.0 0.077 12.2 0.0 1.3 1 1 0 1 1 1 0 Citrate transporter ABC2_membrane_2 PF12679.7 EXF74687.1 - 0.046 13.0 0.0 0.096 11.9 0.0 1.5 1 0 0 1 1 1 0 ABC-2 family transporter protein COG5 PF10392.9 EXF74688.1 - 2.8e-38 131.1 0.6 2.8e-38 131.1 0.6 2.5 3 0 0 3 3 3 1 Golgi transport complex subunit 5 SRX PF09201.10 EXF74688.1 - 0.029 14.2 0.0 0.056 13.3 0.0 1.4 1 0 0 1 1 1 0 SRX, signal recognition particle receptor alpha subunit ATG16 PF08614.11 EXF74688.1 - 0.033 14.4 1.0 0.067 13.4 1.0 1.5 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) DHFR_2 PF06442.11 EXF74688.1 - 0.051 13.4 0.0 0.1 12.5 0.0 1.5 1 0 0 1 1 1 0 R67 dihydrofolate reductase Lebercilin PF15619.6 EXF74688.1 - 0.073 12.7 2.3 0.14 11.8 2.3 1.4 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease GrpE PF01025.19 EXF74688.1 - 0.11 12.2 1.6 0.2 11.3 1.6 1.3 1 0 0 1 1 1 0 GrpE p450 PF00067.22 EXF74689.1 - 6.3e-56 190.0 0.0 9.1e-56 189.5 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 RTA1 PF04479.13 EXF74690.1 - 1.1e-62 211.4 13.5 1.3e-62 211.1 13.5 1.0 1 0 0 1 1 1 1 RTA1 like protein Bac_export_2 PF01312.19 EXF74690.1 - 2.3 7.3 6.9 0.13 11.4 0.2 2.1 2 1 1 3 3 3 0 FlhB HrpN YscU SpaS Family DHHC PF01529.20 EXF74690.1 - 3.6 7.7 14.7 0.37 10.9 0.8 3.0 1 1 2 3 3 3 0 DHHC palmitoyltransferase adh_short_C2 PF13561.6 EXF74692.1 - 1.3e-46 159.0 0.0 1.6e-46 158.8 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF74692.1 - 2.1e-37 128.5 0.0 2.7e-37 128.2 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EXF74692.1 - 1.4e-11 44.7 0.0 1.8e-11 44.3 0.0 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EXF74692.1 - 2.2e-07 30.6 0.0 3.4e-07 30.0 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EXF74692.1 - 8.9e-06 25.0 0.0 1.8e-05 24.0 0.0 1.5 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 EXF74692.1 - 0.00052 19.5 0.0 0.001 18.6 0.0 1.5 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 EXF74692.1 - 0.012 14.7 0.0 0.024 13.7 0.0 1.4 1 0 0 1 1 1 0 RmlD substrate binding domain NAD_binding_2 PF03446.15 EXF74692.1 - 0.021 15.0 0.0 0.57 10.3 0.0 2.2 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 EXF74692.1 - 0.034 14.7 1.1 8.5 7.0 0.3 2.3 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent 3Beta_HSD PF01073.19 EXF74692.1 - 0.039 13.0 0.1 0.13 11.2 0.1 1.8 1 1 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Pyr_redox PF00070.27 EXF74692.1 - 0.045 14.3 0.1 0.14 12.8 0.0 1.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.18 EXF74692.1 - 0.05 13.9 0.0 0.16 12.2 0.0 1.8 2 0 0 2 2 2 0 TrkA-N domain 3HCDH_N PF02737.18 EXF74692.1 - 0.085 12.7 0.0 0.19 11.6 0.0 1.6 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Ank_2 PF12796.7 EXF74693.1 - 4.6e-28 97.6 0.8 6e-11 42.8 0.0 4.6 3 1 1 5 5 5 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EXF74693.1 - 1.6e-22 79.6 3.2 3.6e-05 24.2 0.1 6.4 3 2 4 7 7 7 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EXF74693.1 - 2e-21 73.8 0.7 0.0013 19.1 0.1 8.5 8 0 0 8 8 8 5 Ankyrin repeat Ank PF00023.30 EXF74693.1 - 5.6e-15 55.0 1.8 0.0005 20.4 0.0 8.1 8 0 0 8 8 8 2 Ankyrin repeat Ank_5 PF13857.6 EXF74693.1 - 2.1e-13 50.2 3.3 0.0013 19.0 0.1 6.3 3 2 5 8 8 8 5 Ankyrin repeats (many copies) NACHT PF05729.12 EXF74693.1 - 1.4e-08 34.9 0.0 3.7e-08 33.4 0.0 1.7 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 EXF74693.1 - 3.8e-07 30.7 0.0 2.3e-06 28.1 0.0 2.4 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EXF74693.1 - 1.3e-05 25.5 0.0 5.7e-05 23.4 0.0 2.1 2 0 0 2 2 2 1 AAA domain KAP_NTPase PF07693.14 EXF74693.1 - 0.00016 21.1 0.2 0.085 12.1 0.6 2.5 1 1 1 2 2 2 2 KAP family P-loop domain AAA PF00004.29 EXF74693.1 - 0.051 14.0 0.0 0.31 11.5 0.0 2.3 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) BUD22 PF09073.10 EXF74694.1 - 0.0078 15.6 19.4 0.0078 15.6 19.4 1.6 2 0 0 2 2 2 1 BUD22 RIFIN PF02009.16 EXF74694.1 - 0.25 11.2 0.0 0.25 11.2 0.0 2.6 3 0 0 3 3 3 0 Rifin Phage_holin_2_3 PF16080.5 EXF74694.1 - 0.34 10.7 0.5 0.59 9.9 0.5 1.3 1 0 0 1 1 1 0 Bacteriophage holin family HP1 Myc_target_1 PF15179.6 EXF74694.1 - 3.9 7.3 13.6 0.088 12.7 4.4 3.0 2 1 0 2 2 2 0 Myc target protein 1 TFIIF_alpha PF05793.12 EXF74694.1 - 4.2 5.8 19.2 9 4.8 19.2 1.5 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) cobW PF02492.19 EXF74695.1 - 2.2e-49 167.5 4.7 1.6e-36 125.5 0.3 2.2 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.14 EXF74695.1 - 4.2e-17 61.9 0.0 1.1e-13 50.9 0.0 2.6 2 0 0 2 2 2 2 Cobalamin synthesis protein cobW C-terminal domain MeaB PF03308.16 EXF74695.1 - 4.1e-06 26.0 1.0 0.00036 19.6 0.0 2.3 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB MobB PF03205.14 EXF74695.1 - 0.0047 16.8 0.0 0.0089 15.9 0.0 1.4 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_16 PF13191.6 EXF74695.1 - 0.0065 16.9 2.7 0.011 16.2 0.7 2.3 2 1 0 2 2 2 1 AAA ATPase domain RsgA_GTPase PF03193.16 EXF74695.1 - 0.0083 16.0 0.5 1.4 8.8 0.1 2.4 2 0 0 2 2 2 1 RsgA GTPase Viral_helicase1 PF01443.18 EXF74695.1 - 0.0094 15.7 0.0 0.02 14.6 0.0 1.6 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase AAA_33 PF13671.6 EXF74695.1 - 0.026 14.7 0.1 0.26 11.4 0.0 2.6 3 0 0 3 3 3 0 AAA domain TsaE PF02367.17 EXF74695.1 - 0.026 14.5 0.0 0.063 13.3 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Nop14 PF04147.12 EXF74695.1 - 0.046 11.9 11.1 0.072 11.3 11.1 1.2 1 0 0 1 1 1 0 Nop14-like family NACHT PF05729.12 EXF74695.1 - 0.17 11.8 0.1 0.48 10.3 0.1 1.8 1 0 0 1 1 1 0 NACHT domain Drc1-Sld2 PF11719.8 EXF74695.1 - 0.26 10.8 4.1 0.38 10.2 4.1 1.2 1 0 0 1 1 1 0 DNA replication and checkpoint protein NOA36 PF06524.12 EXF74695.1 - 0.54 9.5 10.6 1.1 8.5 10.6 1.5 1 0 0 1 1 1 0 NOA36 protein AAA_18 PF13238.6 EXF74695.1 - 1.2 9.7 0.0 1.2 9.7 0.0 3.1 4 0 0 4 4 4 0 AAA domain TRAP_alpha PF03896.16 EXF74695.1 - 1.2 8.3 6.5 2 7.5 6.5 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Roughex PF06020.11 EXF74695.1 - 1.4 7.9 9.6 2.2 7.3 9.6 1.2 1 0 0 1 1 1 0 Drosophila roughex protein AAA_11 PF13086.6 EXF74695.1 - 1.5 8.5 4.0 4.1 7.1 0.1 2.8 2 1 0 3 3 3 0 AAA domain RRN3 PF05327.11 EXF74695.1 - 3.8 6.0 8.6 6.8 5.1 8.6 1.4 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Glyco_hydro_61 PF03443.14 EXF74696.1 - 1.2e-54 185.4 0.1 1.6e-54 184.9 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 MG2 PF01835.19 EXF74696.1 - 0.023 15.1 0.0 0.042 14.3 0.0 1.4 1 0 0 1 1 1 0 MG2 domain HET PF06985.11 EXF74697.1 - 3.4e-29 102.1 0.0 8.1e-29 100.9 0.0 1.7 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) DUF4003 PF13170.6 EXF74697.1 - 0.0035 16.8 0.0 0.0081 15.6 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF4003) Pyr_redox_3 PF13738.6 EXF74698.1 - 2.9e-18 66.2 0.0 4.4e-16 59.0 0.0 2.6 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EXF74698.1 - 1.2e-14 54.3 0.0 1.3e-12 47.5 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 EXF74698.1 - 6.9e-13 47.9 0.4 2.8e-10 39.3 0.1 2.4 2 1 0 2 2 2 2 Flavin-binding monooxygenase-like K_oxygenase PF13434.6 EXF74698.1 - 1.1e-09 38.0 0.0 2.2e-06 27.1 0.0 3.0 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 EXF74698.1 - 2.2e-06 27.8 0.0 9.1e-06 25.8 0.0 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 EXF74698.1 - 3e-05 23.4 0.0 0.005 16.1 0.0 2.4 2 0 0 2 2 2 1 FAD binding domain 2-Hacid_dh_C PF02826.19 EXF74698.1 - 5.6e-05 22.6 0.1 0.0019 17.6 0.1 2.2 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyr_redox PF00070.27 EXF74698.1 - 0.00016 22.2 0.0 1.5 9.5 0.0 2.9 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EXF74698.1 - 0.0017 17.7 0.0 0.027 13.7 0.0 2.2 2 0 0 2 2 2 1 Thi4 family HI0933_like PF03486.14 EXF74698.1 - 0.0042 15.9 0.1 0.012 14.4 0.1 1.8 2 0 0 2 2 2 1 HI0933-like protein 3HCDH_N PF02737.18 EXF74698.1 - 0.0042 17.0 0.2 0.94 9.3 0.0 2.3 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DAO PF01266.24 EXF74698.1 - 0.0046 16.6 0.0 0.065 12.8 0.0 2.4 2 0 0 2 2 2 1 FAD dependent oxidoreductase SnoaL_2 PF12680.7 EXF74698.1 - 0.0051 17.4 0.0 0.016 15.9 0.0 1.8 1 1 0 1 1 1 1 SnoaL-like domain FAD_binding_2 PF00890.24 EXF74698.1 - 0.0059 15.7 0.2 0.023 13.8 0.6 1.8 2 0 0 2 2 2 1 FAD binding domain SnoaL_4 PF13577.6 EXF74698.1 - 0.008 16.3 0.0 0.019 15.1 0.0 1.7 1 0 0 1 1 1 1 SnoaL-like domain TrkA_N PF02254.18 EXF74698.1 - 0.013 15.7 0.0 0.13 12.5 0.0 2.2 2 0 0 2 2 2 0 TrkA-N domain Lycopene_cycl PF05834.12 EXF74698.1 - 0.016 14.3 0.0 0.03 13.4 0.0 1.4 1 0 0 1 1 1 0 Lycopene cyclase protein IlvN PF07991.12 EXF74698.1 - 0.016 14.7 0.1 0.89 9.1 0.0 2.4 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain Shikimate_DH PF01488.20 EXF74698.1 - 0.017 15.2 0.0 7.1 6.7 0.0 2.3 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase NAD_binding_9 PF13454.6 EXF74698.1 - 0.051 13.6 0.0 0.52 10.3 0.0 2.4 3 0 0 3 3 3 0 FAD-NAD(P)-binding 2TM PF13239.6 EXF74699.1 - 0.37 11.1 2.3 3.1 8.2 1.5 2.5 2 0 0 2 2 2 0 2TM domain COX1 PF00115.20 EXF74699.1 - 0.93 8.3 16.8 0.91 8.3 7.5 2.1 1 1 1 2 2 2 0 Cytochrome C and Quinol oxidase polypeptide I DUF917 PF06032.12 EXF74700.1 - 1.2e-126 422.3 2.3 1.3e-126 422.2 0.1 2.1 2 1 0 2 2 2 1 Protein of unknown function (DUF917) Hydantoinase_A PF01968.18 EXF74700.1 - 3e-28 98.9 5.1 3.3e-28 98.8 2.6 2.1 1 1 1 2 2 2 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.13 EXF74700.1 - 1e-16 61.1 0.5 3.3e-15 56.3 0.1 2.9 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase N-terminal region StbA PF06406.11 EXF74700.1 - 0.19 11.0 0.3 5 6.3 0.1 2.7 3 0 0 3 3 3 0 StbA protein FtsA PF14450.6 EXF74700.1 - 1.9 8.9 4.8 38 4.8 0.1 3.4 2 1 0 2 2 2 0 Cell division protein FtsA Transp_cyt_pur PF02133.15 EXF74701.1 - 2.6e-100 336.3 29.3 3e-100 336.1 29.3 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Tyrosinase PF00264.20 EXF74702.1 - 5.5e-49 167.5 0.0 7.8e-49 167.0 0.0 1.2 1 0 0 1 1 1 1 Common central domain of tyrosinase V-ATPase_G_2 PF16999.5 EXF74702.1 - 0.16 12.4 0.0 0.25 11.8 0.0 1.2 1 0 0 1 1 1 0 Vacuolar (H+)-ATPase G subunit Fungal_trans_2 PF11951.8 EXF74703.1 - 2e-14 53.2 0.2 3.3e-14 52.5 0.2 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain DUF3829 PF12889.7 EXF74703.1 - 0.097 12.1 0.2 0.52 9.7 0.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3829) Fungal_trans PF04082.18 EXF74704.1 - 4.8e-12 45.5 0.0 7.8e-12 44.8 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF74704.1 - 1.6e-08 34.5 10.4 2.4e-08 33.9 10.4 1.2 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain HET PF06985.11 EXF74705.1 - 1.1e-23 84.2 0.5 1.3e-21 77.5 0.5 2.6 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) LRR_8 PF13855.6 EXF74708.1 - 2.9e-27 94.2 37.9 1.5e-05 24.7 5.7 8.6 4 2 6 11 11 11 9 Leucine rich repeat LRR_4 PF12799.7 EXF74708.1 - 6.7e-24 83.6 37.8 8.7e-06 26.0 1.1 9.1 8 2 2 10 10 10 7 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EXF74708.1 - 0.0074 16.7 26.7 0.76 10.6 0.5 10.1 13 0 0 13 13 13 1 Leucine Rich Repeat LRR_6 PF13516.6 EXF74708.1 - 0.018 15.0 16.1 14 6.0 0.2 8.2 9 0 0 9 9 9 0 Leucine Rich repeat LRR_9 PF14580.6 EXF74708.1 - 0.055 13.0 19.9 2.4 7.6 0.7 5.3 2 2 4 6 6 6 0 Leucine-rich repeat Pec_lyase_C PF00544.19 EXF74709.1 - 5e-13 49.1 12.6 1.7e-08 34.3 3.2 2.6 1 1 2 3 3 3 2 Pectate lyase Beta_helix PF13229.6 EXF74709.1 - 0.0088 15.9 8.7 0.0088 15.9 8.7 2.1 1 1 1 2 2 2 2 Right handed beta helix region Flavokinase PF01687.17 EXF74710.1 - 1.8e-29 102.3 0.0 2.1e-29 102.0 0.0 1.1 1 0 0 1 1 1 1 Riboflavin kinase PAS PF00989.25 EXF74711.1 - 5.5e-05 23.1 0.0 0.00013 22.0 0.0 1.6 1 0 0 1 1 1 1 PAS fold Zn_clus PF00172.18 EXF74711.1 - 0.0034 17.5 8.8 0.0078 16.3 8.8 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.16 EXF74713.1 - 2e-34 119.1 40.2 2.9e-34 118.5 40.2 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF74713.1 - 7.6e-14 51.4 7.0 7.6e-14 51.4 7.0 2.1 2 1 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 EXF74713.1 - 4.2e-08 32.1 3.5 7.1e-08 31.3 3.5 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF2370 PF10176.9 EXF74713.1 - 0.0039 16.9 0.1 0.017 14.8 0.1 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF2370) Cellulase PF00150.18 EXF74714.1 - 9.3e-10 38.4 1.9 9.3e-10 38.4 1.9 1.5 2 0 0 2 2 2 1 Cellulase (glycosyl hydrolase family 5) Radical_SAM PF04055.21 EXF74714.1 - 0.013 15.9 0.1 0.046 14.1 0.0 1.9 2 0 0 2 2 2 0 Radical SAM superfamily Adipogenin PF15202.6 EXF74714.1 - 0.017 15.2 0.0 0.035 14.1 0.0 1.5 1 0 0 1 1 1 0 Adipogenin EphA2_TM PF14575.6 EXF74714.1 - 0.035 15.0 0.0 0.035 15.0 0.0 2.2 2 1 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain DUF4064 PF13273.6 EXF74714.1 - 0.075 13.3 0.0 0.17 12.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4064) SNARE PF05739.19 EXF74714.1 - 7.3 6.7 6.1 18 5.4 6.1 1.7 1 0 0 1 1 1 0 SNARE domain PsaX PF08078.12 EXF74714.1 - 8.5 6.4 6.6 8.2 6.5 0.0 2.3 2 0 0 2 2 2 0 PsaX family F-actin_cap_A PF01267.17 EXF74715.1 - 3.7e-99 331.5 0.0 4.8e-99 331.1 0.0 1.1 1 0 0 1 1 1 1 F-actin capping protein alpha subunit Transket_pyr PF02779.24 EXF74715.1 - 1.1e-42 145.7 0.0 1.9e-42 144.9 0.0 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 EXF74715.1 - 6.6e-33 113.2 0.0 1.6e-32 112.0 0.0 1.6 1 0 0 1 1 1 1 Transketolase, C-terminal domain PFOR_II PF17147.4 EXF74715.1 - 0.0021 18.3 0.0 0.0057 16.9 0.0 1.8 1 0 0 1 1 1 1 Pyruvate:ferredoxin oxidoreductase core domain II ACAS_N PF16177.5 EXF74715.1 - 0.038 13.9 0.0 0.095 12.6 0.0 1.6 1 0 0 1 1 1 0 Acetyl-coenzyme A synthetase N-terminus CSTF2_hinge PF14327.6 EXF74715.1 - 0.073 13.5 0.1 0.24 11.8 0.0 1.9 2 0 0 2 2 2 0 Hinge domain of cleavage stimulation factor subunit 2 Cyt-b5 PF00173.28 EXF74716.1 - 2.1e-23 82.3 0.3 2.8e-23 81.9 0.3 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain DUF2201 PF09967.9 EXF74716.1 - 0.036 14.2 0.0 0.047 13.8 0.0 1.1 1 0 0 1 1 1 0 VWA-like domain (DUF2201) TFA2_Winged_2 PF18121.1 EXF74717.1 - 4.6e-19 67.9 0.5 9.4e-19 66.9 0.5 1.6 1 0 0 1 1 1 1 TFA2 Winged helix domain 2 TFIIE_beta PF02186.15 EXF74717.1 - 8.5e-12 45.2 0.0 1.8e-11 44.1 0.0 1.6 1 0 0 1 1 1 1 TFIIE beta subunit core domain UPF0236 PF06782.11 EXF74717.1 - 0.08 11.6 0.1 0.11 11.1 0.1 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0236) Raco_middle PF17651.1 EXF74717.1 - 0.16 11.6 0.0 0.99 9.1 0.0 2.0 2 0 0 2 2 2 0 RACo middle region DSBA PF01323.20 EXF74718.1 - 2.5e-18 66.6 0.1 2.6e-18 66.5 0.1 1.0 1 0 0 1 1 1 1 DSBA-like thioredoxin domain Thioredoxin_4 PF13462.6 EXF74718.1 - 7.8e-06 26.2 0.0 7.8e-06 26.2 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_5 PF13743.6 EXF74718.1 - 0.019 14.6 0.0 0.022 14.4 0.0 1.1 1 0 0 1 1 1 0 Thioredoxin SGL PF08450.12 EXF74719.1 - 2.1e-68 230.6 0.0 3e-68 230.1 0.0 1.2 1 0 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Arylesterase PF01731.20 EXF74719.1 - 0.02 15.1 0.0 0.049 13.8 0.0 1.6 1 0 0 1 1 1 0 Arylesterase Reg_prop PF07494.11 EXF74719.1 - 0.042 14.1 0.3 1 9.8 0.0 2.7 2 0 0 2 2 2 0 Two component regulator propeller PD40 PF07676.12 EXF74719.1 - 0.088 12.8 0.1 0.28 11.2 0.1 1.8 1 0 0 1 1 1 0 WD40-like Beta Propeller Repeat Goodbye PF17109.5 EXF74720.1 - 0.049 14.1 1.0 14 6.1 0.4 2.3 2 0 0 2 2 2 0 fungal STAND N-terminal Goodbye domain N2227 PF07942.12 EXF74721.1 - 4.2e-60 203.2 0.0 1.1e-59 201.8 0.0 1.6 2 0 0 2 2 2 1 N2227-like protein Methyltransf_11 PF08241.12 EXF74721.1 - 9.1e-05 23.0 0.0 0.00032 21.3 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EXF74721.1 - 0.00018 21.4 0.0 0.00036 20.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF74721.1 - 0.00021 22.0 0.1 0.0014 19.4 0.0 2.4 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF74721.1 - 0.0071 16.1 0.0 0.1 12.4 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF74721.1 - 0.018 15.7 0.0 0.083 13.6 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase domain NFRKB_winged PF14465.6 EXF74721.1 - 0.037 14.2 0.0 0.38 11.0 0.0 2.4 2 0 0 2 2 2 0 NFRKB Winged Helix-like Cellulase PF00150.18 EXF74722.1 - 1.1e-31 110.3 0.1 1.7e-31 109.7 0.1 1.1 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) AP_endonuc_2 PF01261.24 EXF74722.1 - 0.086 12.3 0.0 6.5 6.1 0.1 2.7 2 1 0 2 2 2 0 Xylose isomerase-like TIM barrel Sugar_tr PF00083.24 EXF74724.1 - 1.4e-78 264.8 21.0 1.7e-78 264.5 21.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF74724.1 - 1.6e-23 83.3 34.5 7e-17 61.4 21.0 2.6 1 1 2 3 3 3 2 Major Facilitator Superfamily ThaI PF15514.6 EXF74724.1 - 0.11 12.2 0.1 1.1 8.9 0.1 2.1 2 0 0 2 2 2 0 Restriction endonuclease ThaI RGI_lyase PF18370.1 EXF74727.1 - 7.4e-19 67.8 0.0 3.4e-18 65.7 0.0 2.1 2 0 0 2 2 2 1 Rhamnogalacturonan I lyases beta-sheet domain VCBS PF13517.6 EXF74727.1 - 1.1e-05 26.0 20.8 0.00051 20.6 4.8 6.2 5 1 1 6 6 6 4 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella p450 PF00067.22 EXF74728.1 - 1.4e-45 155.9 0.0 1.7e-45 155.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 ICL PF00463.21 EXF74729.1 - 3e-113 379.1 0.1 3.6e-113 378.8 0.1 1.0 1 0 0 1 1 1 1 Isocitrate lyase family PEP_mutase PF13714.6 EXF74729.1 - 1.4e-07 31.3 0.0 2.3e-07 30.5 0.0 1.3 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase Importin_rep_5 PF18816.1 EXF74729.1 - 0.0031 17.8 0.0 0.006 16.9 0.0 1.5 1 0 0 1 1 1 1 Importin repeat Aminotran_1_2 PF00155.21 EXF74730.1 - 1.3e-18 67.4 0.0 1.6e-18 67.0 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.7 EXF74730.1 - 0.0011 17.9 0.0 0.0022 16.8 0.0 1.5 2 0 0 2 2 2 1 Alanine-glyoxylate amino-transferase Peptidase_M18 PF02127.15 EXF74730.1 - 0.26 10.0 0.0 0.37 9.5 0.0 1.1 1 0 0 1 1 1 0 Aminopeptidase I zinc metalloprotease (M18) MFS_1 PF07690.16 EXF74731.1 - 9.8e-33 113.5 19.8 9.8e-33 113.5 19.8 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily MFS_1_like PF12832.7 EXF74731.1 - 0.00017 20.6 0.4 0.00031 19.7 0.4 1.6 1 0 0 1 1 1 1 MFS_1 like family HpcH_HpaI PF03328.14 EXF74732.1 - 1.7e-25 89.5 0.9 2.4e-25 89.0 0.9 1.2 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family Tetraspanin PF00335.20 EXF74733.1 - 5.3e-05 23.0 0.0 0.0001 22.1 0.0 1.5 1 1 0 1 1 1 1 Tetraspanin family DUF2892 PF11127.8 EXF74733.1 - 7.1 6.7 9.4 9 6.4 0.1 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2892) PI-PLC-X PF00388.19 EXF74734.1 - 6.2e-49 165.3 0.0 9.6e-49 164.7 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 EXF74734.1 - 1.7e-37 128.3 0.0 2.7e-37 127.6 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain C2 PF00168.30 EXF74734.1 - 0.0055 17.0 0.0 0.013 15.8 0.0 1.6 1 1 0 1 1 1 1 C2 domain Asp-Al_Ex PF06826.12 EXF74735.1 - 0.063 13.1 0.1 0.1 12.4 0.1 1.2 1 0 0 1 1 1 0 Predicted Permease Membrane Region PRA1 PF03208.19 EXF74736.1 - 8.9e-35 119.4 0.5 1.4e-34 118.8 0.5 1.3 1 0 0 1 1 1 1 PRA1 family protein DUF1676 PF07898.13 EXF74736.1 - 0.25 11.4 8.7 0.82 9.7 8.7 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1676) DNA_pol_phi PF04931.13 EXF74736.1 - 0.27 9.3 22.9 0.51 8.4 22.9 1.3 1 0 0 1 1 1 0 DNA polymerase phi Nop14 PF04147.12 EXF74736.1 - 0.52 8.4 17.1 0.91 7.7 17.1 1.3 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.12 EXF74736.1 - 0.77 9.1 22.0 0.17 11.3 18.1 1.7 2 0 0 2 2 2 0 SDA1 TT_ORF1 PF02956.14 EXF74736.1 - 4.8 5.7 13.2 6.9 5.2 13.2 1.2 1 0 0 1 1 1 0 TT viral orf 1 DUF3405 PF11885.8 EXF74736.1 - 5.8 5.4 8.2 9 4.8 8.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3405) RRN3 PF05327.11 EXF74736.1 - 9.1 4.7 8.2 12 4.3 8.2 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Myb_DNA-bind_5 PF13873.6 EXF74737.1 - 0.096 12.8 0.2 0.22 11.6 0.2 1.5 1 0 0 1 1 1 0 Myb/SANT-like DNA-binding domain DUF1509 PF07420.11 EXF74737.1 - 4 6.3 7.8 5.4 5.9 7.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1509) GH131_N PF18271.1 EXF74738.1 - 2e-76 257.1 0.0 2.3e-76 256.9 0.0 1.0 1 0 0 1 1 1 1 Glycoside hydrolase 131 catalytic N-terminal domain SurE PF01975.17 EXF74739.1 - 1.6e-45 155.3 0.0 2.2e-45 154.8 0.0 1.2 1 0 0 1 1 1 1 Survival protein SurE Zn_clus PF00172.18 EXF74740.1 - 0.29 11.3 8.0 0.59 10.3 8.0 1.5 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF3235 PF11574.8 EXF74740.1 - 3 8.8 5.0 74 4.3 0.0 4.3 3 1 1 4 4 4 0 Protein of unknown function (DUF3235) DPPIV_N PF00930.21 EXF74741.1 - 3.7e-108 361.4 0.7 1e-107 360.0 0.4 1.9 2 0 0 2 2 2 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.21 EXF74741.1 - 1.9e-52 177.8 2.7 4.1e-52 176.7 2.7 1.5 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 EXF74741.1 - 1.5e-05 25.7 2.1 0.0021 18.7 0.6 3.0 2 1 0 2 2 2 1 Alpha/beta hydrolase family Peptidase_S15 PF02129.18 EXF74741.1 - 3e-05 23.8 2.8 0.00048 19.8 0.9 2.3 1 1 1 2 2 2 2 X-Pro dipeptidyl-peptidase (S15 family) Clathrin PF00637.20 EXF74742.1 - 1.9e-200 656.8 29.5 5.3e-33 113.9 0.8 7.8 7 1 1 8 8 8 7 Region in Clathrin and VPS Clathrin_propel PF01394.20 EXF74742.1 - 1.9e-36 122.6 0.3 5.8e-08 32.7 0.1 6.7 6 0 0 6 6 6 6 Clathrin propeller repeat Clathrin_H_link PF13838.6 EXF74742.1 - 1.2e-30 105.2 0.8 1.2e-30 105.2 0.8 2.3 2 0 0 2 2 2 1 Clathrin-H-link TPR_14 PF13428.6 EXF74742.1 - 0.00013 22.5 8.5 6.2 7.9 0.0 8.1 8 0 0 8 8 7 1 Tetratricopeptide repeat Clathrin-link PF09268.10 EXF74742.1 - 0.012 14.9 0.4 0.031 13.7 0.4 1.8 1 0 0 1 1 1 0 Clathrin, heavy-chain linker PQQ_2 PF13360.6 EXF74742.1 - 0.038 13.6 0.0 4.6 6.8 0.1 3.1 3 0 0 3 3 3 0 PQQ-like domain TPR_7 PF13176.6 EXF74742.1 - 0.067 13.2 7.3 35 4.7 0.0 6.6 8 0 0 8 8 8 0 Tetratricopeptide repeat PPR PF01535.20 EXF74742.1 - 0.083 13.2 0.1 42 4.7 0.0 4.8 4 0 0 4 4 3 0 PPR repeat Coatomer_WDAD PF04053.14 EXF74742.1 - 0.1 11.6 7.4 0.44 9.5 0.3 4.1 5 0 0 5 5 5 0 Coatomer WD associated region TPR_8 PF13181.6 EXF74742.1 - 0.25 11.7 5.9 1.8 9.0 0.1 4.6 6 0 0 6 6 5 0 Tetratricopeptide repeat Vps39_1 PF10366.9 EXF74742.1 - 0.67 10.3 4.8 13 6.1 0.0 5.3 6 1 1 7 7 7 0 Vacuolar sorting protein 39 domain 1 TPR_2 PF07719.17 EXF74742.1 - 0.98 9.7 3.1 18 5.7 0.1 4.6 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF1640 PF07798.11 EXF74744.1 - 4.4e-56 189.7 8.5 6.6e-56 189.1 8.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) GNAT_acetyltr_2 PF13718.6 EXF74744.1 - 0.029 13.8 0.8 0.076 12.4 0.1 1.8 1 1 1 2 2 2 0 GNAT acetyltransferase 2 cwf21 PF08312.12 EXF74744.1 - 0.11 12.7 2.9 0.33 11.1 2.9 1.9 1 1 0 1 1 1 0 cwf21 domain Metal_resist PF13801.6 EXF74744.1 - 0.71 10.1 3.9 4.4 7.5 0.3 2.7 3 0 0 3 3 3 0 Heavy-metal resistance DUF1690 PF07956.11 EXF74744.1 - 2 8.8 11.9 1.7 9.1 4.8 2.2 1 1 1 2 2 2 0 Protein of Unknown function (DUF1690) TPR_MLP1_2 PF07926.12 EXF74744.1 - 9.1 6.4 14.2 3.6 7.7 3.1 2.2 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein MFS_1 PF07690.16 EXF74745.1 - 9.8e-29 100.4 25.1 9.8e-29 100.4 25.1 2.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF74745.1 - 8e-14 51.3 9.8 1.8e-13 50.2 0.1 2.4 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_3 PF05977.13 EXF74745.1 - 0.0004 18.9 6.2 0.077 11.4 1.6 2.2 2 0 0 2 2 2 2 Transmembrane secretion effector FAD_binding_4 PF01565.23 EXF74747.1 - 3.3e-24 85.2 2.3 7.2e-24 84.1 2.3 1.6 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EXF74747.1 - 7.4e-11 42.0 0.6 1.8e-10 40.8 0.6 1.6 1 0 0 1 1 1 1 Berberine and berberine like Cytokin-bind PF09265.10 EXF74747.1 - 0.016 14.6 0.0 0.034 13.5 0.0 1.5 2 0 0 2 2 2 0 Cytokinin dehydrogenase 1, FAD and cytokinin binding DUF3632 PF12311.8 EXF74748.1 - 3.5e-11 43.9 0.1 5.8e-11 43.1 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3632) TRP PF06011.12 EXF74749.1 - 8e-18 64.4 16.6 2.1e-13 49.8 10.5 2.7 2 1 1 3 3 3 2 Transient receptor potential (TRP) ion channel DUF2254 PF10011.9 EXF74749.1 - 2.9 6.6 9.6 1.9 7.2 0.9 3.2 3 1 0 3 3 3 0 Predicted membrane protein (DUF2254) WSC PF01822.19 EXF74750.1 - 2.9e-55 184.4 57.5 4.7e-19 68.4 10.4 4.9 4 0 0 4 4 4 4 WSC domain ASH PF15780.5 EXF74750.1 - 8.7e-06 25.9 6.3 0.026 14.7 0.0 3.4 4 0 0 4 4 4 2 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin DUF1573 PF07610.11 EXF74750.1 - 0.001 19.1 0.0 12 6.1 0.0 3.6 3 0 0 3 3 3 2 Protein of unknown function (DUF1573) Peptidase_M20 PF01546.28 EXF74751.1 - 4.2e-26 91.9 0.0 1.2e-25 90.4 0.0 1.8 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EXF74751.1 - 3.3e-06 27.0 0.0 7.6e-06 25.8 0.0 1.7 1 0 0 1 1 1 1 Peptidase dimerisation domain LPMO_10 PF03067.15 EXF74752.1 - 3.8e-14 53.8 0.6 5.7e-14 53.2 0.6 1.2 1 0 0 1 1 1 1 Lytic polysaccharide mono-oxygenase, cellulose-degrading N_BRCA1_IG PF16158.5 EXF74752.1 - 0.0033 18.1 0.1 0.071 13.8 0.0 2.5 1 1 2 3 3 3 1 Ig-like domain from next to BRCA1 gene Serglycin PF04360.12 EXF74752.1 - 0.042 13.8 2.3 0.081 12.9 2.3 1.4 1 0 0 1 1 1 0 Serglycin DHDPS PF00701.22 EXF74753.1 - 8.1e-12 44.4 0.1 4.4e-07 28.9 0.0 2.0 1 1 1 2 2 2 2 Dihydrodipicolinate synthetase family Methyltransf_25 PF13649.6 EXF74754.1 - 2e-06 28.4 0.0 6.2e-06 26.8 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EXF74754.1 - 3.1e-05 23.9 0.0 5.5e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF74754.1 - 0.00081 20.0 0.0 0.0026 18.4 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF74754.1 - 0.0086 16.8 0.0 0.021 15.6 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF74754.1 - 0.017 14.9 0.0 0.093 12.5 0.0 2.0 1 1 0 1 1 1 0 Methyltransferase domain DUF5560 PF17715.1 EXF74756.1 - 0.011 15.2 2.7 0.19 11.2 0.2 2.1 1 1 1 2 2 2 0 Family of unknown function (DUF5560) Amelin PF05111.12 EXF74756.1 - 0.046 12.9 0.2 0.068 12.3 0.2 1.2 1 0 0 1 1 1 0 Ameloblastin precursor (Amelin) PAN_4 PF14295.6 EXF74757.1 - 2.3e-05 24.2 0.4 4.7e-05 23.2 0.4 1.6 1 0 0 1 1 1 1 PAN domain PAN_1 PF00024.26 EXF74757.1 - 0.0038 17.1 1.3 0.0058 16.6 0.1 1.9 2 0 0 2 2 2 1 PAN domain CytochromB561_N PF09786.9 EXF74757.1 - 0.021 13.9 2.6 0.026 13.5 2.6 1.1 1 0 0 1 1 1 0 Cytochrome B561, N terminal SOG2 PF10428.9 EXF74757.1 - 0.5 9.5 10.2 0.67 9.1 10.2 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein PALP PF00291.25 EXF74759.1 - 1e-38 133.4 0.1 1.3e-38 133.1 0.1 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Peptidase_M13_N PF05649.13 EXF74761.1 - 0.057 13.1 0.0 0.065 12.9 0.0 1.1 1 0 0 1 1 1 0 Peptidase family M13 CD99L2 PF12301.8 EXF74761.1 - 0.24 11.7 2.1 0.38 11.0 2.0 1.4 1 1 0 1 1 1 0 CD99 antigen like protein 2 ADH_zinc_N PF00107.26 EXF74762.1 - 2.6e-15 56.5 0.9 6e-15 55.4 0.6 1.9 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EXF74762.1 - 3.6e-13 49.4 1.0 3.6e-13 49.4 1.0 2.0 2 1 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain AlaDh_PNT_C PF01262.21 EXF74762.1 - 0.02 14.2 1.3 0.032 13.5 1.3 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain ADH_zinc_N_2 PF13602.6 EXF74762.1 - 0.028 15.5 0.8 0.22 12.6 0.8 2.2 1 1 0 1 1 1 0 Zinc-binding dehydrogenase TrkA_N PF02254.18 EXF74762.1 - 0.031 14.5 0.4 0.063 13.5 0.4 1.5 1 0 0 1 1 1 0 TrkA-N domain UDPG_MGDP_dh_N PF03721.14 EXF74762.1 - 0.1 12.2 0.1 0.15 11.6 0.1 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_binding_7 PF13241.6 EXF74762.1 - 0.14 12.6 1.5 1.9 9.0 1.5 2.2 1 1 0 1 1 1 0 Putative NAD(P)-binding Pyr_redox_3 PF13738.6 EXF74762.1 - 0.14 11.3 0.2 0.23 10.7 0.2 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Fungal_trans PF04082.18 EXF74763.1 - 2.7e-34 118.4 0.1 4.8e-34 117.6 0.1 1.4 1 1 0 1 1 1 1 Fungal specific transcription factor domain Abi_C PF14355.6 EXF74763.1 - 0.099 12.8 0.0 0.32 11.1 0.0 1.8 2 0 0 2 2 2 0 Abortive infection C-terminus Aminotran_5 PF00266.19 EXF74764.1 - 7.5e-31 107.4 0.0 3e-30 105.4 0.0 1.7 1 1 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 EXF74764.1 - 0.00081 18.7 0.0 0.0019 17.5 0.0 1.7 2 0 0 2 2 2 1 Aminotransferase class I and II AA_permease PF00324.21 EXF74765.1 - 1.3e-115 386.8 42.2 1.4e-115 386.6 42.2 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EXF74765.1 - 6.5e-30 104.3 45.4 8.2e-30 104.0 45.4 1.1 1 0 0 1 1 1 1 Amino acid permease Sugar_tr PF00083.24 EXF74766.1 - 7.3e-32 110.8 33.3 9.6e-17 61.0 12.1 2.0 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 EXF74766.1 - 4.8e-14 52.1 54.1 6.7e-12 45.0 26.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily CVNH PF08881.10 EXF74767.1 - 2.5e-14 53.8 0.3 3.4e-14 53.4 0.3 1.2 1 0 0 1 1 1 1 CVNH domain 2OG-FeII_Oxy_3 PF13640.6 EXF74768.1 - 1.8e-08 35.2 0.0 3.7e-08 34.1 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily p450 PF00067.22 EXF74769.1 - 9.1e-79 265.3 0.0 1.2e-78 265.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Dioxygenase_C PF00775.21 EXF74770.1 - 4.2e-09 36.1 0.0 7e-09 35.4 0.0 1.3 1 0 0 1 1 1 1 Dioxygenase Phytase PF02333.15 EXF74771.1 - 1.8e-66 224.7 4.3 1.8e-66 224.6 0.8 2.1 2 0 0 2 2 2 1 Phytase EGF_2 PF07974.13 EXF74771.1 - 1e-06 29.0 33.2 0.0037 17.6 11.0 2.5 2 0 0 2 2 2 2 EGF-like domain RVT_1 PF00078.27 EXF74772.1 - 7.4e-06 25.6 0.0 1.6e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) MFS_1 PF07690.16 EXF74773.1 - 1.1e-22 80.5 56.9 2.4e-22 79.4 40.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily PNTB_4TM PF12769.7 EXF74773.1 - 2.7 8.5 9.8 1 9.9 5.8 2.4 2 0 0 2 2 2 0 4TM region of pyridine nucleotide transhydrogenase, mitoch NmrA PF05368.13 EXF74774.1 - 2.6e-25 89.4 0.8 3.2e-25 89.1 0.8 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EXF74774.1 - 6.5e-23 81.6 0.1 9.6e-23 81.0 0.1 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EXF74774.1 - 2.9e-09 36.8 0.1 1.1e-06 28.3 0.1 2.3 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family Sacchrp_dh_NADP PF03435.18 EXF74774.1 - 9.6e-05 22.7 1.5 0.0006 20.1 0.2 2.2 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain 3Beta_HSD PF01073.19 EXF74774.1 - 0.0014 17.7 0.0 0.0024 16.9 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Shikimate_DH PF01488.20 EXF74774.1 - 0.0018 18.3 0.1 0.005 16.9 0.2 1.6 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase RmlD_sub_bind PF04321.17 EXF74774.1 - 0.0018 17.4 0.3 0.004 16.3 0.1 1.6 2 0 0 2 2 2 1 RmlD substrate binding domain Semialdhyde_dh PF01118.24 EXF74774.1 - 0.003 18.0 0.6 0.0078 16.6 0.6 1.7 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain adh_short PF00106.25 EXF74774.1 - 0.0044 16.5 0.3 0.0088 15.5 0.3 1.6 1 0 0 1 1 1 1 short chain dehydrogenase DapB_N PF01113.20 EXF74774.1 - 0.0064 16.6 0.3 0.013 15.6 0.3 1.6 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus NAD_binding_7 PF13241.6 EXF74774.1 - 0.007 16.8 0.4 0.015 15.7 0.4 1.6 1 0 0 1 1 1 1 Putative NAD(P)-binding GDP_Man_Dehyd PF16363.5 EXF74774.1 - 0.0093 15.4 0.0 0.22 10.9 0.0 2.1 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase CoA_binding_2 PF13380.6 EXF74774.1 - 0.021 15.3 0.3 0.051 14.1 0.3 1.6 1 1 0 1 1 1 0 CoA binding domain 3HCDH_N PF02737.18 EXF74774.1 - 0.033 14.1 0.6 0.066 13.1 0.6 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain THF_DHG_CYH_C PF02882.19 EXF74774.1 - 0.14 11.5 0.9 0.32 10.3 0.5 2.0 2 1 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain DFP PF04127.15 EXF74774.1 - 0.84 9.4 5.9 0.18 11.6 2.1 1.7 2 0 0 2 2 2 0 DNA / pantothenate metabolism flavoprotein SIR2 PF02146.17 EXF74778.1 - 1.4e-29 103.3 0.1 3.2e-22 79.3 0.0 2.2 1 1 1 2 2 2 2 Sir2 family MFS_1 PF07690.16 EXF74779.1 - 1e-24 87.2 46.5 1.2e-21 77.1 34.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2678 PF10856.8 EXF74779.1 - 0.057 13.3 0.1 0.21 11.5 0.1 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2678) DUF5582 PF17819.1 EXF74780.1 - 8.8 6.8 13.1 8.9 6.8 0.0 3.9 3 1 1 4 4 4 0 Family of unknown function (DUF5582) Glyco_hydro_61 PF03443.14 EXF74781.1 - 3.8e-65 219.7 0.0 6.3e-65 219.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 CBM_1 PF00734.18 EXF74781.1 - 2e-12 46.8 14.0 6.9e-12 45.1 14.0 2.0 1 0 0 1 1 1 1 Fungal cellulose binding domain 2OG-FeII_Oxy_3 PF13640.6 EXF74782.1 - 4.3e-06 27.5 0.0 6.1e-06 27.1 0.0 1.2 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Fungal_trans_2 PF11951.8 EXF74783.1 - 5.5e-11 41.9 0.2 1.7e-10 40.3 0.2 1.8 1 1 0 1 1 1 1 Fungal specific transcription factor domain Tyr_Deacylase PF02580.16 EXF74783.1 - 0.11 13.1 0.0 0.21 12.1 0.0 1.4 1 0 0 1 1 1 0 D-Tyr-tRNA(Tyr) deacylase V-set_CD47 PF08204.11 EXF74784.1 - 0.037 14.0 0.1 0.066 13.2 0.1 1.5 1 0 0 1 1 1 0 CD47 immunoglobulin-like domain Tannase PF07519.11 EXF74785.1 - 2.5e-93 313.5 0.4 3e-93 313.3 0.4 1.0 1 0 0 1 1 1 1 Tannase and feruloyl esterase Hydrolase_4 PF12146.8 EXF74785.1 - 0.019 14.2 0.0 0.25 10.6 0.0 2.1 2 0 0 2 2 2 0 Serine aminopeptidase, S33 DSBA PF01323.20 EXF74786.1 - 6.2e-11 42.4 0.0 6.5e-11 42.4 0.0 1.0 1 0 0 1 1 1 1 DSBA-like thioredoxin domain DUF1769 PF08588.10 EXF74786.1 - 0.082 13.1 0.0 0.14 12.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1769) zf-C2H2 PF00096.26 EXF74787.1 - 2.6e-22 78.0 25.6 1.8e-05 24.9 0.2 4.7 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EXF74787.1 - 1.6e-17 63.0 27.9 1.7e-06 28.2 1.2 5.6 5 0 0 5 5 5 4 Zinc-finger double domain zf-C2H2_4 PF13894.6 EXF74787.1 - 6.3e-12 45.3 22.9 0.0042 17.8 1.3 4.6 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EXF74787.1 - 3.5e-06 27.2 0.1 4.7 7.6 0.0 4.3 4 0 0 4 4 4 1 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.5 EXF74787.1 - 0.0011 18.7 8.1 0.02 14.6 0.8 3.3 3 0 0 3 3 3 2 zinc-finger C2H2-type zf-met PF12874.7 EXF74787.1 - 0.0012 19.2 7.9 2.8 8.5 0.0 4.1 4 0 0 4 4 4 2 Zinc-finger of C2H2 type zf_UBZ PF18439.1 EXF74787.1 - 0.003 17.1 2.0 1.2 8.8 0.2 3.2 3 0 0 3 3 3 2 Ubiquitin-Binding Zinc Finger zf-C2HC_2 PF13913.6 EXF74787.1 - 0.11 12.5 6.6 4.5 7.3 0.2 3.6 3 0 0 3 3 3 0 zinc-finger of a C2HC-type FOXP-CC PF16159.5 EXF74787.1 - 0.22 12.2 2.6 19 6.0 0.2 3.0 2 1 1 3 3 3 0 FOXP coiled-coil domain zf-MYST PF17772.1 EXF74787.1 - 0.4 10.3 3.1 4.2 7.0 0.1 3.0 3 0 0 3 3 3 0 MYST family zinc finger domain Zn-ribbon_8 PF09723.10 EXF74787.1 - 0.47 10.6 8.9 2.6 8.2 1.0 3.3 1 1 3 4 4 4 0 Zinc ribbon domain zf-C2H2_aberr PF17017.5 EXF74787.1 - 0.49 10.5 1.5 3.4 7.8 0.1 2.1 2 0 0 2 2 2 0 Aberrant zinc-finger XPA_N PF01286.18 EXF74787.1 - 2.7 8.1 7.3 0.85 9.7 0.5 3.0 4 0 0 4 4 4 0 XPA protein N-terminal DUF2256 PF10013.9 EXF74787.1 - 3 8.0 8.6 23 5.2 0.0 3.6 4 0 0 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2256) DZR PF12773.7 EXF74787.1 - 3.8 7.6 8.6 1.7e+02 2.3 8.6 2.4 1 1 0 1 1 1 0 Double zinc ribbon Ogr_Delta PF04606.12 EXF74787.1 - 5.3 7.1 8.5 14 5.8 0.3 2.4 2 0 0 2 2 2 0 Ogr/Delta-like zinc finger Methyltransf_33 PF10017.9 EXF74788.1 - 2.1e-78 263.6 0.0 2.7e-78 263.3 0.0 1.0 1 0 0 1 1 1 1 Histidine-specific methyltransferase, SAM-dependent Fungal_trans_2 PF11951.8 EXF74789.1 - 4e-26 91.7 0.3 5.8e-26 91.2 0.3 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain PSII_Pbs27 PF13326.6 EXF74790.1 - 0.032 14.5 0.0 0.054 13.8 0.0 1.4 1 1 0 1 1 1 0 Photosystem II Pbs27 Scaffolding_pro PF11418.8 EXF74790.1 - 0.048 14.2 0.3 0.14 12.7 0.0 1.9 2 0 0 2 2 2 0 Phi29 scaffolding protein DAO PF01266.24 EXF74792.1 - 4e-35 122.0 0.0 4.6e-35 121.8 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EXF74792.1 - 0.012 14.9 0.0 1.5 8.0 0.0 2.4 2 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EXF74792.1 - 0.015 15.5 0.0 0.071 13.3 0.0 2.2 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain DHBP_synthase PF00926.19 EXF74793.1 - 1.4e-78 262.8 0.0 1.7e-78 262.5 0.0 1.1 1 0 0 1 1 1 1 3,4-dihydroxy-2-butanone 4-phosphate synthase Methyltransf_11 PF08241.12 EXF74794.1 - 1.5e-17 64.0 0.0 2.6e-17 63.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EXF74794.1 - 3.7e-17 62.6 0.0 5.6e-17 62.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF74794.1 - 5e-14 52.8 0.0 8.1e-14 52.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF74794.1 - 6.1e-11 43.0 0.0 9.6e-11 42.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF74794.1 - 8.8e-10 38.6 0.0 1.2e-09 38.1 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EXF74794.1 - 0.00024 20.6 0.0 0.00031 20.2 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 EXF74794.1 - 0.016 14.7 0.0 0.025 14.1 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain CMAS PF02353.20 EXF74794.1 - 0.028 13.7 0.0 0.077 12.3 0.0 1.6 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_2 PF00891.18 EXF74794.1 - 0.11 11.8 0.0 0.17 11.1 0.0 1.2 1 0 0 1 1 1 0 O-methyltransferase domain Pyr_redox_2 PF07992.14 EXF74795.1 - 4.4e-45 154.1 0.3 8.7e-45 153.2 0.3 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NIR_SIR PF01077.22 EXF74795.1 - 1.1e-17 64.0 0.0 2.1e-17 63.1 0.0 1.4 1 0 0 1 1 1 1 Nitrite and sulphite reductase 4Fe-4S domain Pyr_redox PF00070.27 EXF74795.1 - 6.7e-17 61.8 4.2 3.2e-16 59.7 0.4 3.1 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Fer2_BFD PF04324.15 EXF74795.1 - 2.1e-15 56.8 5.9 3.7e-11 43.2 6.1 2.8 2 0 0 2 2 2 2 BFD-like [2Fe-2S] binding domain Rieske_2 PF13806.6 EXF74795.1 - 1e-13 51.1 0.0 2.7e-06 27.3 0.0 2.7 2 0 0 2 2 2 2 Rieske-like [2Fe-2S] domain Rieske PF00355.26 EXF74795.1 - 2e-11 43.7 0.5 7.6e-06 25.8 0.0 3.0 3 0 0 3 3 3 2 Rieske [2Fe-2S] domain NIR_SIR_ferr PF03460.17 EXF74795.1 - 4.6e-08 32.8 0.0 9.9e-08 31.7 0.0 1.6 1 0 0 1 1 1 1 Nitrite/Sulfite reductase ferredoxin-like half domain Rubredoxin_C PF18267.1 EXF74795.1 - 5.7e-06 26.2 0.1 0.097 12.6 0.0 3.6 4 0 0 4 4 4 2 Rubredoxin NAD+ reductase C-terminal domain Amino_oxidase PF01593.24 EXF74795.1 - 0.00038 19.9 0.7 0.58 9.4 0.0 2.3 1 1 0 2 2 2 2 Flavin containing amine oxidoreductase Pyr_redox_3 PF13738.6 EXF74795.1 - 0.00087 18.6 0.0 0.0018 17.6 0.0 1.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EXF74795.1 - 0.011 15.7 0.6 4.4 7.3 0.0 3.2 4 0 0 4 4 4 0 FAD-NAD(P)-binding GIDA PF01134.22 EXF74795.1 - 0.12 11.4 0.9 25 3.8 0.1 3.0 2 1 1 3 3 3 0 Glucose inhibited division protein A Fungal_trans_2 PF11951.8 EXF74796.1 - 1.9e-09 36.8 0.8 2.9e-09 36.2 0.8 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF74796.1 - 1.4e-08 34.7 10.2 3e-08 33.6 10.2 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Sugar_tr PF00083.24 EXF74797.1 - 4.7e-26 91.7 6.6 5.5e-26 91.4 6.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter CsbD PF05532.12 EXF74798.1 - 1.2e-07 31.6 8.0 0.00031 20.6 0.7 2.3 1 1 1 2 2 2 2 CsbD-like Aminotran_1_2 PF00155.21 EXF74801.1 - 7.3e-26 91.2 0.0 2.2e-18 66.6 0.0 3.4 3 1 0 3 3 3 2 Aminotransferase class I and II OKR_DC_1 PF01276.20 EXF74801.1 - 0.0058 15.4 0.0 0.009 14.8 0.0 1.2 1 0 0 1 1 1 1 Orn/Lys/Arg decarboxylase, major domain Beta_elim_lyase PF01212.21 EXF74801.1 - 0.017 14.4 0.2 2.6 7.2 0.1 2.9 3 0 0 3 3 3 0 Beta-eliminating lyase p450 PF00067.22 EXF74802.1 - 3.4e-69 233.8 0.0 4.6e-69 233.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 FAD_binding_1 PF00667.20 EXF74802.1 - 4.8e-24 85.2 0.0 8.9e-24 84.3 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 EXF74802.1 - 5.1e-21 75.4 0.0 1.2e-20 74.1 0.0 1.7 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 EXF74802.1 - 4e-09 37.1 0.0 8.3e-09 36.1 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Flavodoxin_5 PF12724.7 EXF74802.1 - 0.00069 19.9 0.0 0.0012 19.0 0.0 1.4 1 0 0 1 1 1 1 Flavodoxin domain Syntaxin PF00804.25 EXF74802.1 - 0.0023 17.6 0.0 0.0046 16.6 0.0 1.4 1 0 0 1 1 1 1 Syntaxin Oxidored_FMN PF00724.20 EXF74803.1 - 9.4e-58 196.1 0.0 1.1e-50 172.8 0.0 2.3 2 1 0 2 2 2 2 NADH:flavin oxidoreductase / NADH oxidase family AroM PF07302.11 EXF74803.1 - 0.0038 16.6 0.0 0.0065 15.9 0.0 1.3 1 0 0 1 1 1 1 AroM protein PALP PF00291.25 EXF74804.1 - 3.3e-32 112.1 0.0 9.2e-32 110.6 0.0 1.6 2 0 0 2 2 2 1 Pyridoxal-phosphate dependent enzyme Rhodanese PF00581.20 EXF74804.1 - 7.6e-08 32.8 0.0 2.1e-07 31.4 0.0 1.8 1 0 0 1 1 1 1 Rhodanese-like domain MFS_1 PF07690.16 EXF74805.1 - 1.6e-49 168.8 59.5 4.6e-40 137.6 42.0 2.8 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EXF74805.1 - 1.8e-19 69.6 22.8 2.4e-19 69.2 22.8 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EXF74805.1 - 4.2e-17 62.1 5.4 4.2e-17 62.1 5.4 3.7 3 1 1 4 4 4 1 Sugar (and other) transporter MerC PF03203.14 EXF74805.1 - 2.2 8.8 0.0 2.2 8.8 0.0 4.8 3 1 1 4 4 4 0 MerC mercury resistance protein Sdh_cyt PF01127.22 EXF74807.1 - 5.8e-15 55.4 5.5 7.5e-15 55.0 5.5 1.1 1 0 0 1 1 1 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit TAF6_C PF07571.13 EXF74808.1 - 8.4e-28 96.5 0.0 1.8e-27 95.5 0.0 1.6 1 0 0 1 1 1 1 TAF6 C-terminal HEAT repeat domain TAF PF02969.17 EXF74808.1 - 2.9e-22 78.6 0.0 7.8e-22 77.2 0.0 1.8 2 0 0 2 2 2 1 TATA box binding protein associated factor (TAF) CBFD_NFYB_HMF PF00808.23 EXF74808.1 - 0.0027 18.0 0.0 0.0088 16.3 0.0 1.9 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EXF74808.1 - 0.016 15.6 0.1 0.026 14.9 0.1 1.4 1 0 0 1 1 1 0 Core histone H2A/H2B/H3/H4 Bromo_TP PF07524.13 EXF74808.1 - 0.047 13.7 0.0 0.11 12.5 0.0 1.6 1 0 0 1 1 1 0 Bromodomain associated Aldo_ket_red PF00248.21 EXF74809.1 - 3.9e-67 226.5 0.0 4.3e-67 226.4 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Methyltransf_23 PF13489.6 EXF74810.1 - 1.2e-24 87.0 0.0 1.9e-24 86.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF74810.1 - 5.8e-11 43.0 0.0 1.5e-10 41.7 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF74810.1 - 1.4e-08 35.4 0.0 9e-08 32.8 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF74810.1 - 2.1e-08 34.1 0.0 1.2e-07 31.7 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF74810.1 - 7.4e-06 26.5 0.0 1.5e-05 25.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EXF74810.1 - 0.0021 17.5 0.0 0.0033 16.9 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_4 PF02390.17 EXF74810.1 - 0.01 15.3 0.0 0.03 13.8 0.0 1.8 1 0 0 1 1 1 0 Putative methyltransferase Methyltransf_16 PF10294.9 EXF74810.1 - 0.011 15.4 0.0 0.046 13.4 0.0 1.8 2 0 0 2 2 2 0 Lysine methyltransferase MTS PF05175.14 EXF74810.1 - 0.016 14.7 0.0 0.031 13.8 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain FtsJ PF01728.19 EXF74810.1 - 0.045 13.9 0.0 0.08 13.0 0.0 1.5 1 0 0 1 1 1 0 FtsJ-like methyltransferase Ubie_methyltran PF01209.18 EXF74810.1 - 0.14 11.4 0.0 1.4 8.2 0.0 2.5 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family DJ-1_PfpI PF01965.24 EXF74811.1 - 4e-14 52.7 0.0 1.6e-13 50.8 0.0 2.0 1 1 0 1 1 1 1 DJ-1/PfpI family ThiJ_like PF17124.5 EXF74811.1 - 7.7e-12 45.3 0.0 2.7e-11 43.5 0.0 1.8 1 1 0 1 1 1 1 ThiJ/PfpI family-like GATase_3 PF07685.14 EXF74811.1 - 0.068 12.8 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain Peptidase_C26 PF07722.13 EXF74811.1 - 0.089 12.5 0.0 0.16 11.7 0.0 1.4 2 0 0 2 2 2 0 Peptidase C26 PLU-1 PF08429.11 EXF74812.1 - 3.1e-109 365.2 17.7 3.1e-106 355.4 16.3 2.2 2 0 0 2 2 2 2 PLU-1-like protein JmjC PF02373.22 EXF74812.1 - 6.9e-44 148.9 0.2 1.7e-43 147.7 0.2 1.7 1 0 0 1 1 1 1 JmjC domain, hydroxylase ARID PF01388.21 EXF74812.1 - 2.3e-21 76.2 0.0 7.3e-21 74.6 0.0 1.9 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain PHD PF00628.29 EXF74812.1 - 3.6e-18 65.2 32.1 5.5e-10 39.0 7.4 3.8 3 0 0 3 3 3 2 PHD-finger JmjN PF02375.17 EXF74812.1 - 9.1e-16 57.5 1.3 2.2e-15 56.3 1.3 1.7 1 0 0 1 1 1 1 jmjN domain zf-C5HC2 PF02928.16 EXF74812.1 - 2.2e-12 47.2 4.8 2.2e-12 47.2 4.8 1.9 2 0 0 2 2 1 1 C5HC2 zinc finger zf-HC5HC2H PF13771.6 EXF74812.1 - 0.0064 16.7 18.4 0.029 14.6 1.5 3.5 3 0 0 3 3 3 2 PHD-like zinc-binding domain C1_1 PF00130.22 EXF74812.1 - 0.012 15.4 16.5 0.19 11.6 0.5 3.4 3 0 0 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-HC5HC2H_2 PF13832.6 EXF74812.1 - 0.046 13.9 17.4 0.19 11.9 0.2 3.3 3 0 0 3 3 3 0 PHD-zinc-finger like domain zf-PHD-like PF15446.6 EXF74812.1 - 1 8.9 16.5 0.063 12.9 2.2 3.1 3 0 0 3 3 3 0 PHD/FYVE-zinc-finger like domain PHD_2 PF13831.6 EXF74812.1 - 2.8 7.6 12.7 0.12 12.0 2.0 2.9 2 0 0 2 2 2 0 PHD-finger zf-RING_2 PF13639.6 EXF74812.1 - 7.9 6.9 22.7 13 6.2 7.9 3.0 2 0 0 2 2 2 0 Ring finger domain GIY-YIG PF01541.24 EXF74813.1 - 6.6e-12 45.5 0.0 1.2e-11 44.7 0.0 1.4 1 0 0 1 1 1 1 GIY-YIG catalytic domain zf-HC5HC2H PF13771.6 EXF74813.1 - 0.00029 21.0 2.4 0.00053 20.2 2.4 1.3 1 0 0 1 1 1 1 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 EXF74813.1 - 0.00061 19.9 1.7 0.001 19.2 1.7 1.3 1 0 0 1 1 1 1 PHD-zinc-finger like domain FANCL_C PF11793.8 EXF74813.1 - 0.00074 19.6 3.0 0.0013 18.9 3.0 1.3 1 0 0 1 1 1 1 FANCL C-terminal domain PHD_Oberon PF07227.11 EXF74813.1 - 0.0076 16.1 0.8 0.012 15.5 0.8 1.2 1 0 0 1 1 1 1 PHD - plant homeodomain finger protein T5orf172 PF10544.9 EXF74813.1 - 0.14 12.7 0.0 0.29 11.7 0.0 1.5 1 0 0 1 1 1 0 T5orf172 domain zf-RING-like PF08746.11 EXF74813.1 - 0.42 11.0 8.4 0.89 9.9 8.4 1.6 1 0 0 1 1 1 0 RING-like domain Prok-RING_1 PF14446.6 EXF74813.1 - 2.1 8.3 9.4 0.17 11.8 2.9 2.1 1 1 1 2 2 2 0 Prokaryotic RING finger family 1 zf-RING_2 PF13639.6 EXF74813.1 - 4.2 7.8 7.3 8.3 6.8 7.3 1.5 1 0 0 1 1 1 0 Ring finger domain PHD PF00628.29 EXF74813.1 - 9.6 6.2 7.5 16 5.5 7.5 1.4 1 0 0 1 1 1 0 PHD-finger Pkinase PF00069.25 EXF74815.1 - 2e-29 102.8 0.0 2.5e-29 102.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF74815.1 - 2.8e-14 53.0 0.0 5.8e-14 52.0 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EXF74815.1 - 0.015 14.1 0.0 0.021 13.6 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Pox_ser-thr_kin PF05445.11 EXF74815.1 - 0.24 10.3 0.0 0.33 9.9 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase DUF3449 PF11931.8 EXF74816.1 - 6.9e-79 263.9 0.6 2.5e-78 262.1 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF3449) SF3A3 PF16837.5 EXF74816.1 - 5.6e-26 90.9 0.5 1.2e-25 89.8 0.5 1.6 1 0 0 1 1 1 1 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 SF3a60_bindingd PF12108.8 EXF74816.1 - 4e-12 45.8 0.1 8.3e-12 44.8 0.1 1.6 1 0 0 1 1 1 1 Splicing factor SF3a60 binding domain zf-met PF12874.7 EXF74816.1 - 9.1e-09 35.4 1.6 7.1e-07 29.4 0.7 2.4 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EXF74816.1 - 7.6e-07 29.3 0.8 7.6e-07 29.3 0.8 2.6 2 1 0 2 2 2 1 Zinc-finger double-stranded RNA-binding PRP9_N PF16958.5 EXF74816.1 - 3e-05 24.1 4.6 0.043 13.8 0.8 2.9 1 1 1 2 2 2 2 Pre-mRNA-splicing factor PRP9 N-terminus zf-C2H2_2 PF12756.7 EXF74816.1 - 0.0012 19.2 1.5 0.016 15.6 0.6 2.6 2 0 0 2 2 2 1 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 EXF74816.1 - 0.017 15.9 1.0 2.6 9.1 0.1 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger zf-U1 PF06220.12 EXF74816.1 - 0.13 12.0 0.4 0.38 10.6 0.4 1.8 1 0 0 1 1 1 0 U1 zinc finger zf-C2H2 PF00096.26 EXF74816.1 - 0.52 10.9 4.8 0.88 10.1 0.7 2.5 2 0 0 2 2 2 0 Zinc finger, C2H2 type DEAD PF00270.29 EXF74817.1 - 7.7e-42 143.0 0.1 1.3e-41 142.3 0.1 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EXF74817.1 - 2.7e-33 114.6 0.0 9.7e-33 112.8 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain AAA_30 PF13604.6 EXF74817.1 - 0.0005 19.8 0.1 0.00075 19.3 0.1 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EXF74817.1 - 0.0014 18.9 0.1 0.012 16.0 0.1 2.2 2 0 0 2 2 2 1 AAA domain ResIII PF04851.15 EXF74817.1 - 0.0023 18.0 0.0 0.0045 17.0 0.0 1.5 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit DUF5393 PF17371.2 EXF74817.1 - 0.053 11.7 0.1 0.084 11.0 0.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5393) Flavi_DEAD PF07652.14 EXF74817.1 - 0.054 13.5 0.2 0.18 11.8 0.0 2.0 2 1 0 2 2 2 0 Flavivirus DEAD domain TniB PF05621.11 EXF74817.1 - 0.068 12.6 0.0 0.14 11.6 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein Helicase_RecD PF05127.14 EXF74817.1 - 0.081 12.8 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 Helicase AAA_22 PF13401.6 EXF74817.1 - 0.17 12.2 1.0 0.82 9.9 1.0 2.0 1 1 0 1 1 1 0 AAA domain FtsH_ext PF06480.15 EXF74818.1 - 0.79 10.1 2.9 0.69 10.3 1.1 1.8 2 0 0 2 2 2 0 FtsH Extracellular TauD PF02668.16 EXF74819.1 - 1.1e-45 156.5 0.3 1.6e-45 156.0 0.3 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF3530 PF12048.8 EXF74820.1 - 0.72 9.2 2.2 6 6.2 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3530) Abhydrolase_1 PF00561.20 EXF74822.1 - 2.2e-23 83.2 0.0 1.4e-22 80.6 0.0 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EXF74822.1 - 3e-16 60.7 0.9 5.6e-16 59.8 0.9 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EXF74822.1 - 4.7e-11 42.4 0.0 6.8e-08 32.1 0.0 2.0 2 0 0 2 2 2 2 Serine aminopeptidase, S33 DUF1726 PF08351.11 EXF74822.1 - 0.19 11.7 0.1 0.6 10.1 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1726) Ribosomal_L9_N PF01281.19 EXF74822.1 - 0.25 10.9 0.2 0.73 9.4 0.1 1.8 2 0 0 2 2 2 0 Ribosomal protein L9, N-terminal domain Peptidase_S28 PF05577.12 EXF74823.1 - 1.6e-52 178.8 0.0 8.6e-52 176.4 0.0 1.8 1 1 0 1 1 1 1 Serine carboxypeptidase S28 GMC_oxred_N PF00732.19 EXF74824.1 - 1.1e-51 176.1 0.0 1.4e-51 175.6 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EXF74824.1 - 3.2e-24 86.1 0.4 6.1e-24 85.2 0.4 1.4 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.24 EXF74824.1 - 9.5e-05 21.6 0.1 0.031 13.4 0.0 2.3 2 0 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 EXF74824.1 - 0.0086 16.3 0.0 0.024 14.9 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EXF74824.1 - 0.014 15.0 2.0 0.072 12.7 1.7 2.2 2 1 0 2 2 2 0 FAD dependent oxidoreductase Thi4 PF01946.17 EXF74824.1 - 0.08 12.2 0.1 0.08 12.2 0.1 1.8 2 0 0 2 2 2 0 Thi4 family Pyr_redox_2 PF07992.14 EXF74824.1 - 0.11 11.8 0.0 1 8.5 0.0 2.3 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EXF74824.1 - 0.12 11.6 0.0 1.2 8.4 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Malate_synthase PF01274.22 EXF74827.1 - 7.6e-213 707.5 0.0 9.5e-213 707.2 0.0 1.1 1 0 0 1 1 1 1 Malate synthase Fungal_trans PF04082.18 EXF74827.1 - 1e-11 44.4 0.1 3.7e-11 42.6 0.1 2.0 1 1 0 1 1 1 1 Fungal specific transcription factor domain HpcH_HpaI PF03328.14 EXF74827.1 - 0.0094 15.1 0.0 0.02 14.1 0.0 1.5 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family GerA PF03323.13 EXF74828.1 - 0.011 14.2 0.0 0.015 13.8 0.0 1.1 1 0 0 1 1 1 0 Bacillus/Clostridium GerA spore germination protein DUF3176 PF11374.8 EXF74829.1 - 1.4e-34 118.5 1.6 1.4e-34 118.5 1.6 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF3176) p450 PF00067.22 EXF74831.1 - 2.1e-53 181.7 0.0 4.1e-53 180.8 0.0 1.4 1 1 0 1 1 1 1 Cytochrome P450 Peptidase_M14 PF00246.24 EXF74832.1 - 5.2e-27 95.4 1.0 7.6e-27 94.8 1.0 1.2 1 0 0 1 1 1 1 Zinc carboxypeptidase KGG PF10685.9 EXF74832.1 - 0.22 11.8 2.5 0.44 10.9 2.5 1.5 1 0 0 1 1 1 0 Stress-induced bacterial acidophilic repeat motif SRP54 PF00448.22 EXF74833.1 - 1.7e-75 252.9 2.8 2.7e-75 252.3 1.6 1.9 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.19 EXF74833.1 - 1.5e-30 105.7 5.9 1.5e-30 105.7 5.9 4.1 3 2 2 5 5 4 1 Signal peptide binding domain SRP54_N PF02881.19 EXF74833.1 - 5.6e-20 71.4 0.2 1.5e-19 70.0 0.2 1.8 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain AAA_33 PF13671.6 EXF74833.1 - 3.9e-06 27.1 0.0 9.2e-06 25.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain cobW PF02492.19 EXF74833.1 - 8.4e-06 25.5 1.1 4.5e-05 23.1 1.0 2.2 2 1 0 2 2 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_17 PF13207.6 EXF74833.1 - 4.1e-05 24.0 0.1 4.1e-05 24.0 0.1 2.4 2 0 0 2 2 1 1 AAA domain AAA_16 PF13191.6 EXF74833.1 - 0.00017 22.0 0.0 0.00036 21.0 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain MMR_HSR1 PF01926.23 EXF74833.1 - 0.0015 18.6 0.3 0.067 13.3 0.1 3.2 3 1 0 3 3 3 1 50S ribosome-binding GTPase AAA_30 PF13604.6 EXF74833.1 - 0.0018 18.1 0.0 0.0051 16.6 0.0 1.8 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 EXF74833.1 - 0.0023 17.3 0.0 0.0053 16.1 0.0 1.6 1 0 0 1 1 1 1 Zeta toxin APS_kinase PF01583.20 EXF74833.1 - 0.0027 17.6 0.0 0.0055 16.6 0.0 1.5 1 0 0 1 1 1 1 Adenylylsulphate kinase Thymidylate_kin PF02223.17 EXF74833.1 - 0.0057 16.4 0.4 0.017 14.8 0.0 2.0 2 0 0 2 2 2 1 Thymidylate kinase SRPRB PF09439.10 EXF74833.1 - 0.0063 16.0 0.6 2.6 7.4 0.8 3.2 2 1 0 2 2 2 1 Signal recognition particle receptor beta subunit AAA_22 PF13401.6 EXF74833.1 - 0.0066 16.7 0.0 0.017 15.4 0.0 1.8 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 EXF74833.1 - 0.0067 16.4 0.3 0.016 15.2 0.3 1.6 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit CbiA PF01656.23 EXF74833.1 - 0.0074 16.3 0.0 0.022 14.8 0.0 1.8 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_18 PF13238.6 EXF74833.1 - 0.0076 16.8 0.0 0.018 15.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain ATP_bind_1 PF03029.17 EXF74833.1 - 0.009 15.8 0.3 0.04 13.7 0.1 2.1 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein AAA_28 PF13521.6 EXF74833.1 - 0.024 14.9 0.0 0.045 14.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain MobB PF03205.14 EXF74833.1 - 0.027 14.4 0.4 0.055 13.4 0.0 1.7 2 0 0 2 2 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_19 PF13245.6 EXF74833.1 - 0.043 14.1 0.1 0.099 13.0 0.1 1.6 1 0 0 1 1 1 0 AAA domain 6PF2K PF01591.18 EXF74833.1 - 0.082 12.2 0.0 0.13 11.5 0.0 1.3 1 0 0 1 1 1 0 6-phosphofructo-2-kinase Arf PF00025.21 EXF74833.1 - 0.1 12.0 0.1 0.39 10.2 0.0 2.0 2 0 0 2 2 2 0 ADP-ribosylation factor family AAA PF00004.29 EXF74833.1 - 0.13 12.7 0.3 0.37 11.2 0.2 1.9 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) SKA2 PF16740.5 EXF74833.1 - 0.83 9.5 4.5 9.4 6.1 1.6 2.5 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 2 PAP2 PF01569.21 EXF74834.1 - 6.7e-26 90.7 4.3 6.7e-26 90.7 4.3 1.6 2 0 0 2 2 2 1 PAP2 superfamily DUF3915 PF13054.6 EXF74835.1 - 0.032 14.2 4.8 0.034 14.1 4.5 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3915) zinc_ribbon_2 PF13240.6 EXF74835.1 - 0.037 13.8 0.9 0.057 13.2 0.9 1.3 1 0 0 1 1 1 0 zinc-ribbon domain BRD4_CDT PF17105.5 EXF74835.1 - 0.85 9.3 10.4 0.34 10.5 5.1 2.1 2 0 0 2 2 2 0 C-terminal domain of bromodomain protein 4 MFS_1 PF07690.16 EXF74836.1 - 1.1e-42 146.3 37.6 2.2e-36 125.5 25.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 EXF74836.1 - 3.4 5.8 18.6 0.027 12.8 4.1 2.8 1 1 1 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Lactamase_B PF00753.27 EXF74838.1 - 8.9e-07 29.1 0.1 1.5e-06 28.3 0.1 1.6 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EXF74838.1 - 0.00037 20.1 0.0 0.00081 19.0 0.0 1.6 1 1 0 1 1 1 1 Beta-lactamase superfamily domain E1-E2_ATPase PF00122.20 EXF74839.1 - 4.4e-34 117.6 22.2 7.9e-30 103.7 0.5 4.0 5 0 0 5 5 5 2 E1-E2 ATPase Cation_ATPase_C PF00689.21 EXF74839.1 - 9.5e-30 103.6 5.5 9.5e-30 103.6 5.5 2.3 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 EXF74839.1 - 3.5e-21 76.5 1.2 4.8e-17 63.0 0.6 3.2 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EXF74839.1 - 3.1e-20 72.0 0.0 6.7e-20 71.0 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 EXF74839.1 - 1.7e-14 53.2 0.0 4e-14 52.0 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EXF74839.1 - 1.7e-06 28.0 0.6 0.00021 21.1 0.6 2.4 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase ADH_zinc_N PF00107.26 EXF74841.1 - 1.8e-10 40.9 0.1 1.5e-09 37.9 0.1 2.3 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EXF74841.1 - 8.4e-05 22.4 0.0 0.00015 21.6 0.0 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain AlaDh_PNT_C PF01262.21 EXF74841.1 - 0.0028 17.0 0.1 0.0045 16.3 0.1 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain adh_short PF00106.25 EXF74842.1 - 1.8e-17 63.5 0.0 3.4e-13 49.5 0.0 2.2 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EXF74842.1 - 3.1e-13 49.8 0.0 1.2e-12 47.9 0.0 1.7 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF74842.1 - 0.013 15.4 0.1 0.039 13.9 0.1 1.7 2 0 0 2 2 2 0 KR domain DUF3479 PF11965.8 EXF74842.1 - 0.044 13.9 0.1 0.15 12.2 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3479) GDP_Man_Dehyd PF16363.5 EXF74842.1 - 0.11 11.9 0.0 0.19 11.1 0.0 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Zn_clus PF00172.18 EXF74843.1 - 1.3e-06 28.4 9.7 2.4e-06 27.6 9.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MgpC PF05220.12 EXF74843.1 - 0.082 12.2 0.1 0.14 11.5 0.1 1.3 1 0 0 1 1 1 0 MgpC protein precursor DUF3425 PF11905.8 EXF74844.1 - 2.7e-19 69.4 0.1 4.8e-19 68.6 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) HSD3 PF15244.6 EXF74844.1 - 0.044 13.3 0.2 0.057 12.9 0.2 1.1 1 0 0 1 1 1 0 Spermatogenesis-associated protein 7, or HSD3 Cytochrome-c551 PF10643.9 EXF74845.1 - 0.27 10.8 3.7 0.61 9.6 3.7 1.5 1 0 0 1 1 1 0 Photosystem P840 reaction-centre cytochrome c-551 7tm_3 PF00003.22 EXF74845.1 - 7 6.3 16.8 0.11 12.2 2.0 2.5 1 1 1 2 2 2 0 7 transmembrane sweet-taste receptor of 3 GCPR PARP PF00644.20 EXF74846.1 - 1.1e-56 191.6 1.2 1.8e-56 190.9 0.0 2.0 2 1 1 3 3 3 1 Poly(ADP-ribose) polymerase catalytic domain PARP_reg PF02877.14 EXF74846.1 - 7.7e-45 152.3 0.3 1.7e-44 151.2 0.1 1.7 2 0 0 2 2 2 1 Poly(ADP-ribose) polymerase, regulatory domain WGR PF05406.15 EXF74846.1 - 9.3e-22 76.9 0.5 9.3e-22 76.9 0.5 2.3 2 0 0 2 2 2 1 WGR domain BRCT PF00533.26 EXF74846.1 - 2.7e-08 34.1 0.1 6.9e-08 32.8 0.1 1.7 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 EXF74846.1 - 3.6e-08 33.2 0.4 9e-08 32.0 0.4 1.8 1 0 0 1 1 1 1 twin BRCT domain BRCT_2 PF16589.5 EXF74846.1 - 0.052 14.0 0.0 0.13 12.7 0.0 1.7 1 0 0 1 1 1 0 BRCT domain, a BRCA1 C-terminus domain Ndc1_Nup PF09531.10 EXF74846.1 - 2.1 6.9 4.9 2.5 6.7 4.9 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Macoilin PF09726.9 EXF74846.1 - 2.4 6.6 12.2 3.6 6.0 12.2 1.2 1 0 0 1 1 1 0 Macoilin family F-box PF00646.33 EXF74847.1 - 0.00029 20.6 0.2 0.00069 19.4 0.2 1.6 1 0 0 1 1 1 1 F-box domain Amidohydro_2 PF04909.14 EXF74847.1 - 0.0024 17.7 0.0 0.0035 17.2 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase F-box-like PF12937.7 EXF74847.1 - 0.004 17.0 0.0 0.0072 16.2 0.0 1.4 1 0 0 1 1 1 1 F-box-like ThiJ_like PF17124.5 EXF74848.1 - 3.1e-52 177.1 0.0 3.8e-52 176.8 0.0 1.0 1 0 0 1 1 1 1 ThiJ/PfpI family-like DJ-1_PfpI PF01965.24 EXF74848.1 - 2.2e-08 34.1 0.0 7e-08 32.5 0.0 1.7 1 1 0 1 1 1 1 DJ-1/PfpI family p450 PF00067.22 EXF74850.1 - 3.7e-44 151.3 0.0 5e-44 150.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Bac_globin PF01152.21 EXF74850.1 - 0.067 13.3 0.0 0.14 12.3 0.0 1.4 1 0 0 1 1 1 0 Bacterial-like globin DUF3328 PF11807.8 EXF74851.1 - 0.98 9.1 5.1 0.18 11.5 0.3 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF3328) MF_alpha_N PF05436.11 EXF74852.1 - 0.14 12.0 1.1 0.17 11.8 1.0 1.3 1 1 0 1 1 1 0 Mating factor alpha precursor N-terminus AMMECR1 PF01871.17 EXF74853.1 - 2.1e-45 154.4 0.0 2.5e-45 154.1 0.0 1.2 1 1 0 1 1 1 1 AMMECR1 DUF5342 PF17277.2 EXF74853.1 - 0.033 14.6 0.0 0.075 13.4 0.0 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5342) Crystall PF00030.19 EXF74853.1 - 0.1 12.8 0.1 0.23 11.7 0.1 1.5 1 0 0 1 1 1 0 Beta/Gamma crystallin Comm PF15957.5 EXF74854.1 - 0.1 12.9 0.0 0.15 12.5 0.0 1.2 1 0 0 1 1 1 0 Commissureless SET PF00856.28 EXF74855.1 - 2.5e-09 37.7 0.0 2e-08 34.8 0.0 2.3 2 1 0 2 2 2 1 SET domain Paramyxo_PNT PF14320.6 EXF74856.1 - 0.092 11.9 0.6 0.13 11.4 0.6 1.1 1 0 0 1 1 1 0 Phosphoprotein P region PNT disordered Methyltransf_2 PF00891.18 EXF74857.1 - 1.6e-22 79.9 0.0 2.5e-22 79.2 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain DUF5401 PF17380.2 EXF74858.1 - 8.5 4.3 5.9 9.8 4.1 5.9 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5401) Aldolase_II PF00596.21 EXF74859.1 - 5.8e-12 45.9 0.0 7.9e-12 45.5 0.0 1.2 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain Cutinase PF01083.22 EXF74860.1 - 4.1e-28 98.5 0.2 1.2e-26 93.7 0.2 2.0 1 1 0 1 1 1 1 Cutinase DUF2974 PF11187.8 EXF74860.1 - 0.0085 15.7 0.0 0.011 15.4 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2974) VirJ PF06057.11 EXF74860.1 - 0.018 15.0 0.0 0.026 14.4 0.0 1.2 1 0 0 1 1 1 0 Bacterial virulence protein (VirJ) Palm_thioest PF02089.15 EXF74860.1 - 0.036 13.9 0.0 0.047 13.5 0.0 1.2 1 0 0 1 1 1 0 Palmitoyl protein thioesterase PE-PPE PF08237.11 EXF74860.1 - 0.05 13.1 0.0 0.064 12.8 0.0 1.3 1 0 0 1 1 1 0 PE-PPE domain Abhydrolase_1 PF00561.20 EXF74860.1 - 0.059 13.0 0.0 0.067 12.8 0.0 1.1 1 0 0 1 1 1 0 alpha/beta hydrolase fold Cutinase PF01083.22 EXF74861.1 - 3.9e-40 137.7 0.3 4.7e-40 137.4 0.3 1.1 1 0 0 1 1 1 1 Cutinase DUF2974 PF11187.8 EXF74861.1 - 0.028 14.0 0.0 0.041 13.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) PE-PPE PF08237.11 EXF74861.1 - 0.057 13.0 0.0 0.093 12.3 0.0 1.3 1 0 0 1 1 1 0 PE-PPE domain R_equi_Vir PF05526.11 EXF74862.1 - 0.00021 21.2 0.4 0.00021 21.2 0.4 2.1 1 1 1 2 2 2 1 Rhodococcus equi virulence-associated protein DUF5053 PF16476.5 EXF74862.1 - 0.072 12.8 0.1 0.15 11.7 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5053) eIF2A PF08662.11 EXF74865.1 - 2.5e-77 259.1 0.0 1e-76 257.1 0.0 1.9 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A WD40 PF00400.32 EXF74865.1 - 0.0055 17.5 0.2 5.1 8.1 0.1 4.5 4 1 0 4 4 4 1 WD domain, G-beta repeat COX14 PF14880.6 EXF74866.1 - 0.085 12.7 0.2 0.14 12.0 0.2 1.3 1 0 0 1 1 1 0 Cytochrome oxidase c assembly RPAP1_C PF08620.10 EXF74867.1 - 2.2e-27 95.0 0.0 4.1e-27 94.1 0.0 1.5 1 0 0 1 1 1 1 RPAP1-like, C-terminal RPAP1_N PF08621.10 EXF74867.1 - 2.6e-19 68.7 6.8 2.6e-19 68.7 6.8 1.6 2 0 0 2 2 2 1 RPAP1-like, N-terminal HUN PF08729.10 EXF74868.1 - 2.3e-07 30.7 0.7 5.6e-07 29.5 0.7 1.6 1 0 0 1 1 1 1 HPC2 and ubinuclein domain SURF6 PF04935.12 EXF74869.1 - 2.4e-48 164.6 35.0 2.4e-48 164.6 35.0 4.3 2 1 1 3 3 3 1 Surfeit locus protein 6 RRP14 PF15459.6 EXF74869.1 - 3.1e-17 62.9 0.8 3.1e-17 62.9 0.8 7.8 6 1 1 7 7 7 1 60S ribosome biogenesis protein Rrp14 GPP34 PF05719.11 EXF74870.1 - 1.3e-70 237.5 0.3 1.7e-70 237.2 0.3 1.1 1 0 0 1 1 1 1 Golgi phosphoprotein 3 (GPP34) Aldo_ket_red PF00248.21 EXF74871.1 - 3.2e-60 203.8 0.0 4.1e-60 203.5 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Sugar_tr PF00083.24 EXF74873.1 - 3.7e-78 263.4 18.3 4.5e-78 263.1 18.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF74873.1 - 3.3e-18 65.8 25.4 3.3e-18 65.8 25.4 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily MFS_2 PF13347.6 EXF74873.1 - 1.4e-05 23.9 17.0 0.00097 17.8 0.8 2.9 2 1 1 3 3 3 2 MFS/sugar transport protein MFS_4 PF06779.14 EXF74873.1 - 0.00025 20.5 4.5 0.00025 20.5 4.5 2.2 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB FUSC PF04632.12 EXF74873.1 - 0.065 11.8 3.7 0.18 10.3 3.7 1.6 1 0 0 1 1 1 0 Fusaric acid resistance protein family Bromodomain PF00439.25 EXF74875.1 - 5.5e-18 64.8 1.6 6.5e-18 64.6 0.2 1.9 2 0 0 2 2 2 1 Bromodomain Bromo_TP PF07524.13 EXF74875.1 - 4.3e-08 33.1 0.0 8.6e-08 32.1 0.0 1.5 1 0 0 1 1 1 1 Bromodomain associated PSII_Pbs27 PF13326.6 EXF74875.1 - 0.073 13.4 1.0 0.18 12.1 0.7 1.8 1 1 0 1 1 1 0 Photosystem II Pbs27 Bromo_TP_like PF17027.5 EXF74875.1 - 0.1 12.7 0.0 0.26 11.4 0.0 1.7 1 0 0 1 1 1 0 Histone-fold protein PBP1_TM PF14812.6 EXF74875.1 - 0.81 10.1 8.9 3.4 8.1 2.0 3.3 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal ING PF12998.7 EXF74875.1 - 9 7.0 10.8 0.52 10.9 0.7 3.1 3 0 0 3 3 3 0 Inhibitor of growth proteins N-terminal histone-binding VanZ PF04892.12 EXF74876.1 - 1.6e-09 38.5 3.5 2.3e-09 38.0 3.5 1.2 1 0 0 1 1 1 1 VanZ like family GSAP-16 PF14959.6 EXF74876.1 - 0.028 14.3 0.2 0.038 13.9 0.2 1.2 1 0 0 1 1 1 0 gamma-Secretase-activating protein C-term Ferric_reduct PF01794.19 EXF74877.1 - 1.4e-18 67.2 10.8 3.3e-18 66.0 10.8 1.7 1 0 0 1 1 1 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 EXF74877.1 - 1.9e-15 57.3 0.0 2.8e-15 56.8 0.0 1.2 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EXF74877.1 - 1.9e-06 27.9 0.0 1.1e-05 25.5 0.0 2.1 1 1 0 1 1 1 1 FAD-binding domain NAD_binding_1 PF00175.21 EXF74877.1 - 1.7e-05 25.4 0.0 0.031 14.9 0.0 2.4 2 0 0 2 2 2 2 Oxidoreductase NAD-binding domain DUF4231 PF14015.6 EXF74877.1 - 0.4 11.2 3.4 0.45 11.0 1.8 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF4231) CorA PF01544.18 EXF74878.1 - 0.00027 20.3 3.2 0.0023 17.3 3.3 2.0 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein Mit_KHE1 PF10173.9 EXF74878.1 - 0.081 13.0 1.0 2.3 8.2 0.1 2.9 2 1 0 2 2 2 0 Mitochondrial K+-H+ exchange-related Peptidase_S64 PF08192.11 EXF74879.1 - 1.1e-06 27.5 0.1 1.9e-06 26.7 0.1 1.3 1 1 0 1 1 1 1 Peptidase family S64 Trypsin_2 PF13365.6 EXF74879.1 - 8.3e-05 23.5 0.6 0.00083 20.3 1.0 2.5 2 1 0 2 2 2 1 Trypsin-like peptidase domain Peptidase_S32 PF05579.13 EXF74879.1 - 0.0021 17.3 0.4 0.0033 16.7 0.4 1.2 1 0 0 1 1 1 1 Equine arteritis virus serine endopeptidase S32 Trypsin PF00089.26 EXF74879.1 - 0.13 12.1 0.2 0.31 10.8 0.2 1.6 1 0 0 1 1 1 0 Trypsin Raftlin PF15250.6 EXF74880.1 - 0.065 12.0 1.5 0.097 11.4 1.5 1.2 1 0 0 1 1 1 0 Raftlin Ank_2 PF12796.7 EXF74881.1 - 1.1e-29 102.8 0.0 4.8e-07 30.3 0.0 6.6 4 3 3 7 7 7 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EXF74881.1 - 1.3e-21 76.6 0.0 0.0019 18.7 0.0 6.9 5 1 3 8 8 8 7 Ankyrin repeats (many copies) Ank_5 PF13857.6 EXF74881.1 - 1.2e-20 73.3 0.2 3.9e-05 23.8 0.0 6.8 6 0 0 6 6 6 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EXF74881.1 - 5.1e-19 66.4 0.0 0.031 14.8 0.0 9.5 11 0 0 11 11 11 4 Ankyrin repeat Ank PF00023.30 EXF74881.1 - 2.2e-17 62.7 0.0 0.00028 21.2 0.0 7.6 7 0 0 7 7 7 3 Ankyrin repeat NACHT PF05729.12 EXF74881.1 - 0.00028 20.8 0.0 0.0011 18.9 0.0 2.0 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 EXF74881.1 - 0.0045 17.3 0.0 0.016 15.4 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EXF74881.1 - 0.0057 17.1 0.0 0.031 14.7 0.0 2.2 2 0 0 2 2 2 1 AAA ATPase domain AAA_18 PF13238.6 EXF74881.1 - 0.042 14.4 0.0 4 8.0 0.0 3.1 2 1 0 2 2 2 0 AAA domain Ribonuc_L-PSP PF01042.21 EXF74882.1 - 5.9e-36 123.1 0.0 6.8e-36 122.9 0.0 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP RRM_1 PF00076.22 EXF74883.1 - 5.3e-11 42.2 0.0 9.2e-11 41.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EXF74883.1 - 3.5e-05 23.4 0.0 7.2e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 EXF74883.1 - 0.029 14.4 0.9 0.095 12.8 0.1 2.1 2 0 0 2 2 2 0 RNA binding motif RRM_occluded PF16842.5 EXF74883.1 - 0.095 12.6 0.0 0.21 11.5 0.0 1.5 1 0 0 1 1 1 0 Occluded RNA-recognition motif SRP-alpha_N PF04086.13 EXF74883.1 - 4.1 7.3 24.1 2.4 8.0 10.6 2.2 2 0 0 2 2 2 0 Signal recognition particle, alpha subunit, N-terminal RF-1 PF00472.20 EXF74884.1 - 1.7e-13 50.6 3.7 2.6e-13 49.9 3.7 1.2 1 0 0 1 1 1 1 RF-1 domain VIT1 PF01988.19 EXF74884.1 - 0.61 9.9 2.9 0.84 9.5 2.9 1.1 1 0 0 1 1 1 0 VIT family Pkinase PF00069.25 EXF74885.1 - 5.5e-72 242.3 0.0 6.8e-72 242.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF74885.1 - 1.4e-29 103.2 0.0 1.9e-29 102.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EXF74885.1 - 2.4e-07 30.4 0.0 3.4e-07 29.9 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EXF74885.1 - 0.00013 20.9 0.0 0.00023 20.1 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EXF74885.1 - 0.00059 19.8 0.1 0.00093 19.2 0.1 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 EXF74885.1 - 0.00065 19.1 0.0 0.0011 18.4 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Fungal_trans_2 PF11951.8 EXF74886.1 - 8.9e-06 24.8 0.5 1.3e-05 24.2 0.5 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain MHYT PF03707.16 EXF74886.1 - 0.056 13.6 0.1 0.15 12.2 0.1 1.7 1 0 0 1 1 1 0 Bacterial signalling protein N terminal repeat PQQ_3 PF13570.6 EXF74887.1 - 0.021 15.3 11.0 0.052 14.1 0.2 4.6 5 1 0 5 5 5 0 PQQ-like domain Aim19 PF10315.9 EXF74887.1 - 0.25 11.7 1.4 0.74 10.1 0.2 2.5 3 0 0 3 3 3 0 Altered inheritance of mitochondria protein 19 CLN3 PF02487.17 EXF74889.1 - 8.3e-36 123.9 3.9 3.6e-35 121.8 3.9 1.8 1 1 0 1 1 1 1 CLN3 protein SurE PF01975.17 EXF74890.1 - 0.17 11.7 0.2 0.26 11.0 0.2 1.3 1 0 0 1 1 1 0 Survival protein SurE AOX PF01786.17 EXF74891.1 - 0.16 11.5 0.0 0.24 10.9 0.0 1.3 1 0 0 1 1 1 0 Alternative oxidase DASH_Spc34 PF08657.10 EXF74895.1 - 1e-50 172.9 0.0 2.4e-25 89.8 0.0 2.0 1 1 1 2 2 2 2 DASH complex subunit Spc34 CAP_N PF01213.19 EXF74895.1 - 0.067 12.7 0.3 0.11 12.0 0.3 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal SlyX PF04102.12 EXF74895.1 - 0.099 13.3 5.7 0.85 10.3 0.2 2.8 2 0 0 2 2 2 0 SlyX Merozoite_SPAM PF07133.11 EXF74895.1 - 1.1 9.3 15.3 1.7 8.6 15.3 1.2 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) DSBA PF01323.20 EXF74896.1 - 6.2e-33 114.2 0.0 7e-33 114.0 0.0 1.0 1 0 0 1 1 1 1 DSBA-like thioredoxin domain Thioredoxin_3 PF13192.6 EXF74896.1 - 0.00043 20.3 0.3 0.013 15.5 0.2 2.3 2 0 0 2 2 2 1 Thioredoxin domain Thioredoxin_2 PF13098.6 EXF74896.1 - 0.0013 19.2 0.0 0.025 15.0 0.0 2.2 2 0 0 2 2 2 1 Thioredoxin-like domain PEP_mutase PF13714.6 EXF74896.1 - 0.036 13.5 0.1 0.057 12.9 0.1 1.2 1 0 0 1 1 1 0 Phosphoenolpyruvate phosphomutase Thioredoxin_5 PF13743.6 EXF74896.1 - 0.067 12.9 0.0 0.6 9.8 0.0 2.0 2 0 0 2 2 2 0 Thioredoxin Thioredoxin_4 PF13462.6 EXF74896.1 - 0.09 12.9 0.0 0.23 11.6 0.0 1.7 2 1 0 2 2 2 0 Thioredoxin DUF1525 PF07511.11 EXF74896.1 - 0.19 11.9 0.0 0.4 10.8 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1525) zf-RING_2 PF13639.6 EXF74897.1 - 1.3e-07 31.8 13.8 2.2e-07 31.1 13.8 1.4 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 EXF74897.1 - 2.4e-05 24.5 11.0 5.5e-05 23.4 11.0 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 EXF74897.1 - 4.9e-05 23.1 10.0 7.2e-05 22.6 10.0 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EXF74897.1 - 0.00012 21.8 10.2 0.0002 21.1 10.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EXF74897.1 - 0.00026 20.8 13.9 0.00043 20.1 13.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EXF74897.1 - 0.095 12.6 7.5 0.17 11.8 7.5 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 EXF74897.1 - 1.6 8.8 6.4 4.3 7.5 6.5 1.7 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.5 EXF74897.1 - 1.7 8.4 9.6 4.2 7.2 9.6 1.6 1 0 0 1 1 1 0 RING-like zinc finger Drc1-Sld2 PF11719.8 EXF74898.1 - 6.4e-90 302.9 29.1 7.3e-90 302.7 29.1 1.0 1 0 0 1 1 1 1 DNA replication and checkpoint protein RRN3 PF05327.11 EXF74898.1 - 0.44 9.0 1.5 0.71 8.3 1.5 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 FMO-like PF00743.19 EXF74900.1 - 3.3e-30 105.0 0.0 5.1e-15 54.9 0.0 3.0 3 0 0 3 3 3 3 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 EXF74900.1 - 1.2e-13 51.0 0.0 4.6e-09 35.9 0.0 2.6 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EXF74900.1 - 5.9e-13 48.7 0.7 2.3e-10 40.2 0.0 3.1 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EXF74900.1 - 8.1e-12 45.4 0.1 1.5e-05 25.1 0.0 3.5 3 0 0 3 3 3 3 FAD-NAD(P)-binding K_oxygenase PF13434.6 EXF74900.1 - 3.3e-09 36.3 0.9 1.3e-06 27.8 0.0 3.3 3 1 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 EXF74900.1 - 0.00061 20.0 0.4 0.0018 18.5 0.0 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 EXF74900.1 - 0.0034 16.7 0.4 0.023 13.9 0.1 2.1 2 0 0 2 2 2 1 Thi4 family DAO PF01266.24 EXF74900.1 - 0.0043 16.7 5.3 0.23 11.0 0.6 3.4 3 1 0 3 3 3 1 FAD dependent oxidoreductase UPF0149 PF03695.13 EXF74900.1 - 0.015 15.6 0.2 0.025 14.9 0.2 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0149) Semialdhyde_dh PF01118.24 EXF74900.1 - 0.14 12.6 0.0 0.47 10.9 0.0 1.9 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain MFS_1 PF07690.16 EXF74901.1 - 4.2e-35 121.3 20.6 4.2e-35 121.3 20.6 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily CbtA PF09490.10 EXF74901.1 - 0.0018 18.1 3.8 0.31 10.8 1.0 3.3 3 0 0 3 3 3 2 Probable cobalt transporter subunit (CbtA) Cation_ATPase_C PF00689.21 EXF74901.1 - 0.39 10.4 0.0 0.39 10.4 0.0 3.4 2 2 1 3 3 3 0 Cation transporting ATPase, C-terminus Alk_phosphatase PF00245.20 EXF74902.1 - 1.7e-84 284.2 0.0 2e-84 283.9 0.0 1.0 1 0 0 1 1 1 1 Alkaline phosphatase DNA_methylase PF00145.17 EXF74904.1 - 3.4e-35 122.0 0.0 6.5e-35 121.0 0.0 1.4 1 0 0 1 1 1 1 C-5 cytosine-specific DNA methylase BAH PF01426.18 EXF74904.1 - 9.2e-06 25.5 0.0 0.039 13.8 0.0 2.6 2 0 0 2 2 2 2 BAH domain DUF155 PF02582.14 EXF74905.1 - 9.3e-48 162.6 0.0 1.3e-47 162.1 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 Cupin_1 PF00190.22 EXF74905.1 - 0.17 11.4 0.0 0.33 10.5 0.0 1.5 1 0 0 1 1 1 0 Cupin YflT PF11181.8 EXF74907.1 - 0.028 14.9 0.4 0.052 14.1 0.4 1.4 1 0 0 1 1 1 0 Heat induced stress protein YflT FAM27 PF15832.5 EXF74907.1 - 0.14 12.7 5.0 0.3 11.7 5.0 1.6 1 0 0 1 1 1 0 FAM27 D and E protein family DUF3915 PF13054.6 EXF74907.1 - 1.1 9.2 6.1 2.3 8.2 6.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Atrophin-1 PF03154.15 EXF74907.1 - 1.3 7.2 9.8 1.7 6.8 9.8 1.1 1 0 0 1 1 1 0 Atrophin-1 family PilJ_C PF18223.1 EXF74908.1 - 0.1 13.1 2.3 0.19 12.2 1.8 1.8 1 1 0 1 1 1 0 Pili PilJ C-terminal domain Transposase_24 PF03004.14 EXF74909.1 - 0.13 12.4 0.5 0.49 10.5 0.1 2.2 2 0 0 2 2 2 0 Plant transposase (Ptta/En/Spm family) KfrA_N PF11740.8 EXF74909.1 - 6.4 7.5 11.4 0.37 11.5 1.0 3.1 3 0 0 3 3 3 0 Plasmid replication region DNA-binding N-term Asp PF00026.23 EXF74910.1 - 7.9e-110 367.2 0.1 9.9e-110 366.9 0.1 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EXF74910.1 - 3.1e-16 60.1 0.9 2.4e-09 37.7 0.6 2.3 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EXF74910.1 - 0.0001 22.9 0.0 1.1 10.0 0.0 3.3 2 1 0 2 2 2 2 Aspartyl protease gag-asp_proteas PF13975.6 EXF74910.1 - 0.00076 20.0 0.0 1.7 9.3 0.0 2.9 2 0 0 2 2 2 2 gag-polyprotein putative aspartyl protease TAXi_C PF14541.6 EXF74910.1 - 0.0034 17.2 0.0 0.019 14.7 0.0 2.2 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal SHMT PF00464.19 EXF74911.1 - 2.6e-207 688.2 0.0 3e-207 688.0 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Cys_Met_Meta_PP PF01053.20 EXF74911.1 - 0.054 12.0 0.0 0.091 11.3 0.0 1.3 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme Hce2 PF14856.6 EXF74912.1 - 1.1e-18 67.4 0.0 1.5e-18 67.0 0.0 1.2 1 0 0 1 1 1 1 Pathogen effector; putative necrosis-inducing factor AAA_16 PF13191.6 EXF74913.1 - 6.1e-08 33.2 0.0 2.8e-07 31.1 0.0 2.1 1 0 0 1 1 1 1 AAA ATPase domain Abhydrolase_6 PF12697.7 EXF74913.1 - 7e-05 23.5 0.0 0.00043 21.0 0.0 2.4 2 0 0 2 2 2 1 Alpha/beta hydrolase family DUF676 PF05057.14 EXF74913.1 - 0.00043 19.9 0.4 0.00099 18.7 0.4 1.6 1 1 0 1 1 1 1 Putative serine esterase (DUF676) PGAP1 PF07819.13 EXF74913.1 - 0.002 17.9 0.0 0.0034 17.1 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein RuvB_N PF05496.12 EXF74913.1 - 0.0082 15.9 0.0 0.042 13.6 0.0 2.0 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain NB-ARC PF00931.22 EXF74913.1 - 0.018 14.2 0.0 0.043 13.0 0.0 1.5 2 0 0 2 2 2 0 NB-ARC domain AAA_33 PF13671.6 EXF74913.1 - 0.019 15.1 0.2 0.63 10.2 0.0 2.9 3 0 0 3 3 3 0 AAA domain TniB PF05621.11 EXF74913.1 - 0.064 12.7 0.0 0.16 11.3 0.0 1.6 1 0 0 1 1 1 0 Bacterial TniB protein Hydrolase_4 PF12146.8 EXF74913.1 - 0.09 12.0 0.0 0.27 10.5 0.0 1.8 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Sigma54_activat PF00158.26 EXF74913.1 - 0.19 11.4 0.0 0.38 10.4 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain Syntaxin-6_N PF09177.11 EXF74913.1 - 0.25 11.9 1.1 0.74 10.4 0.0 2.3 2 0 0 2 2 2 0 Syntaxin 6, N-terminal FHA PF00498.26 EXF74914.1 - 6.4e-15 55.3 0.0 1.1e-14 54.5 0.0 1.4 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 EXF74914.1 - 0.0078 16.5 0.0 0.12 12.7 0.0 2.2 1 1 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain VHS PF00790.19 EXF74915.1 - 9.5e-46 155.1 0.1 4e-45 153.1 0.0 2.1 3 0 0 3 3 3 1 VHS domain GAT PF03127.14 EXF74915.1 - 1.3e-18 67.1 0.4 1.3e-18 67.1 0.4 2.3 3 0 0 3 3 3 1 GAT domain Alpha_adaptinC2 PF02883.20 EXF74915.1 - 5.2e-17 62.1 0.0 1.7e-16 60.5 0.0 1.8 1 0 0 1 1 1 1 Adaptin C-terminal domain GGA_N-GAT PF18308.1 EXF74915.1 - 4.3e-08 32.6 0.0 1.3e-07 31.1 0.0 1.8 1 0 0 1 1 1 1 GGA N-GAT domain Ribo_biogen_C PF04034.13 EXF74916.1 - 2e-49 166.5 0.0 2.8e-49 166.1 0.0 1.2 1 0 0 1 1 1 1 Ribosome biogenesis protein, C-terminal RLI PF04068.15 EXF74916.1 - 5.8e-11 42.0 1.1 5.8e-11 42.0 1.1 1.7 2 0 0 2 2 2 1 Possible Fer4-like domain in RNase L inhibitor, RLI BUD22 PF09073.10 EXF74916.1 - 1.8 7.8 24.7 3 7.1 24.7 1.3 1 0 0 1 1 1 0 BUD22 GTP_EFTU PF00009.27 EXF74917.1 - 2e-34 118.8 3.4 5.4e-33 114.2 3.4 2.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 EXF74917.1 - 2.9e-27 94.9 1.4 7.2e-27 93.6 1.0 1.9 2 0 0 2 2 2 1 Translation-initiation factor 2 MMR_HSR1 PF01926.23 EXF74917.1 - 1.2e-10 41.4 0.1 3.7e-10 39.9 0.1 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase IF2_N PF04760.15 EXF74917.1 - 2.9e-07 30.2 0.0 5.7e-07 29.3 0.0 1.5 1 0 0 1 1 1 1 Translation initiation factor IF-2, N-terminal region RsgA_GTPase PF03193.16 EXF74917.1 - 3.8e-07 30.1 0.4 3.8e-05 23.7 0.0 2.4 1 1 1 2 2 2 1 RsgA GTPase Arf PF00025.21 EXF74917.1 - 8.4e-05 22.1 0.0 0.00017 21.1 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family FeoB_N PF02421.18 EXF74917.1 - 0.00012 21.6 0.3 0.00043 19.8 0.1 2.1 2 1 0 2 2 2 1 Ferrous iron transport protein B SRPRB PF09439.10 EXF74917.1 - 0.00033 20.1 0.1 0.00083 18.8 0.1 1.6 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 EXF74917.1 - 0.0026 17.4 0.1 0.0044 16.6 0.1 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EXF74917.1 - 0.0035 17.5 0.0 0.0063 16.7 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU_D4 PF14578.6 EXF74917.1 - 0.012 15.5 1.8 0.017 15.0 0.3 2.0 2 0 0 2 2 2 0 Elongation factor Tu domain 4 PduV-EutP PF10662.9 EXF74917.1 - 0.083 12.6 0.1 0.25 11.1 0.1 1.8 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation ATP_bind_1 PF03029.17 EXF74917.1 - 0.13 12.0 0.0 0.53 10.0 0.0 1.8 1 1 0 1 1 1 0 Conserved hypothetical ATP binding protein PP28 PF10252.9 EXF74919.1 - 3.8e-26 91.4 18.7 3.8e-26 91.4 18.7 3.3 2 1 1 3 3 3 2 Casein kinase substrate phosphoprotein PP28 CoA_trans PF01144.23 EXF74921.1 - 2.2e-96 321.4 1.4 5.5e-59 199.2 0.0 2.0 2 0 0 2 2 2 2 Coenzyme A transferase Nrap_D4 PF17405.2 EXF74922.1 - 2.3e-59 200.4 0.0 5.2e-59 199.2 0.0 1.6 1 0 0 1 1 1 1 Nrap protein nucleotidyltransferase domain 4 Nrap_D5 PF17406.2 EXF74922.1 - 9e-58 194.6 1.0 6.5e-57 191.8 0.7 2.3 2 0 0 2 2 2 1 Nrap protein PAP/OAS1-like domain 5 Nrap_D2 PF17403.2 EXF74922.1 - 3.5e-53 179.4 0.4 2.2e-49 167.1 0.0 2.6 2 0 0 2 2 2 2 Nrap protein PAP/OAS-like domain Nrap_D3 PF17404.2 EXF74922.1 - 6.1e-47 159.7 0.1 1.5e-46 158.4 0.1 1.7 1 0 0 1 1 1 1 Nrap protein domain 3 Nrap PF03813.14 EXF74922.1 - 1.3e-45 155.1 0.1 2.2e-45 154.4 0.1 1.4 1 0 0 1 1 1 1 Nrap protein domain 1 Nrap_D6 PF17407.2 EXF74922.1 - 6.2e-37 126.8 0.0 1.4e-36 125.7 0.0 1.7 1 0 0 1 1 1 1 Nrap protein domain 6 Requiem_N PF14051.6 EXF74922.1 - 0.22 11.7 0.6 0.74 10.1 0.1 2.1 2 0 0 2 2 2 0 N-terminal domain of DPF2/REQ. DUF5011 PF16403.5 EXF74923.1 - 0.0073 16.4 0.0 0.063 13.4 0.0 2.8 2 0 0 2 2 2 1 Domain of unknown function (DUF5011) zf-C4H2 PF10146.9 EXF74923.1 - 0.081 13.2 0.0 0.18 12.1 0.0 1.5 1 0 0 1 1 1 0 Zinc finger-containing protein I-set PF07679.16 EXF74923.1 - 0.15 12.1 0.0 11 6.2 0.0 3.8 4 0 0 4 4 4 0 Immunoglobulin I-set domain Peptidase_C12 PF01088.21 EXF74924.1 - 3.3e-61 206.7 0.0 5.1e-61 206.1 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 FXR_C1 PF16096.5 EXF74924.1 - 7.9 6.8 7.9 3.5 7.9 0.1 2.8 2 0 0 2 2 2 0 Fragile X-related 1 protein C-terminal region 2 Transglut_core2 PF13369.6 EXF74925.1 - 2.5e-18 66.1 0.0 4e-18 65.5 0.0 1.3 1 0 0 1 1 1 1 Transglutaminase-like superfamily F-box-like PF12937.7 EXF74925.1 - 5.8e-08 32.5 1.9 1.8e-07 30.9 1.1 2.2 2 0 0 2 2 2 1 F-box-like YccV-like PF08755.11 EXF74925.1 - 9.2e-05 22.9 0.4 0.0016 18.9 0.4 2.4 1 1 0 1 1 1 1 Hemimethylated DNA-binding protein YccV like F-box PF00646.33 EXF74925.1 - 0.00019 21.2 0.7 0.00052 19.8 0.7 1.8 1 0 0 1 1 1 1 F-box domain DUF2868 PF11067.8 EXF74925.1 - 0.025 14.1 0.1 0.04 13.4 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2868) Cnn_1N PF07989.11 EXF74926.1 - 3.4e-26 91.2 3.3 3.4e-26 91.2 3.3 18.5 4 2 13 18 18 18 1 Centrosomin N-terminal motif 1 PACT_coil_coil PF10495.9 EXF74926.1 - 1.7e-25 89.4 2.2 1.7e-25 89.4 2.2 6.0 7 0 0 7 7 7 1 Pericentrin-AKAP-450 domain of centrosomal targeting protein Spc7 PF08317.11 EXF74926.1 - 0.00024 20.1 222.4 0.0037 16.2 26.9 9.8 1 1 10 11 11 11 7 Spc7 kinetochore protein DUF1664 PF07889.12 EXF74926.1 - 0.003 17.6 7.3 0.003 17.6 7.3 13.4 2 1 12 16 16 16 5 Protein of unknown function (DUF1664) MscS_porin PF12795.7 EXF74926.1 - 0.0048 16.5 13.1 0.0048 16.5 13.1 9.4 2 1 7 9 9 9 2 Mechanosensitive ion channel porin domain KASH_CCD PF14662.6 EXF74926.1 - 0.0051 16.7 16.4 0.0051 16.7 16.4 10.3 2 2 4 8 8 8 3 Coiled-coil region of CCDC155 or KASH TPR_MLP1_2 PF07926.12 EXF74926.1 - 0.008 16.2 17.9 0.008 16.2 17.9 14.0 3 1 7 13 13 13 4 TPR/MLP1/MLP2-like protein Halo_GVPC PF05465.13 EXF74926.1 - 2.2 8.6 12.3 12 6.3 0.1 5.3 4 0 0 4 4 4 0 Halobacterial gas vesicle protein C (GVPC) repeat Peptidase_C14 PF00656.22 EXF74927.1 - 8e-65 219.2 0.0 1e-64 218.8 0.0 1.1 1 0 0 1 1 1 1 Caspase domain Raptor_N PF14538.6 EXF74927.1 - 0.16 12.0 0.0 0.63 10.0 0.0 2.0 2 0 0 2 2 2 0 Raptor N-terminal CASPase like domain DUF3611 PF12263.8 EXF74928.1 - 0.35 10.7 3.2 1.2 9.0 1.6 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3611) HD PF01966.22 EXF74929.1 - 2.1e-05 24.8 0.4 0.00016 21.9 0.1 2.2 2 0 0 2 2 2 1 HD domain AMPK1_CBM PF16561.5 EXF74930.1 - 0.096 12.9 0.0 0.26 11.5 0.0 1.7 1 1 0 1 1 1 0 Glycogen recognition site of AMP-activated protein kinase Sec3_C PF09763.9 EXF74930.1 - 0.53 8.6 4.1 0.6 8.4 4.1 1.1 1 0 0 1 1 1 0 Exocyst complex component Sec3 Presenilin PF01080.17 EXF74930.1 - 1 8.0 4.3 1.4 7.6 4.3 1.2 1 0 0 1 1 1 0 Presenilin NPR3 PF03666.13 EXF74930.1 - 2.1 7.0 8.2 2.8 6.6 8.2 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 MAP70 PF07058.11 EXF74930.1 - 6.6 5.4 6.6 8.9 4.9 6.6 1.1 1 0 0 1 1 1 0 Microtubule-associated protein 70 Arf PF00025.21 EXF74931.1 - 3e-69 232.0 1.5 8.2e-36 123.1 0.4 2.0 2 0 0 2 2 2 2 ADP-ribosylation factor family Roc PF08477.13 EXF74931.1 - 5.5e-10 39.5 0.0 1.5e-08 34.8 0.0 2.1 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EXF74931.1 - 2.6e-09 36.8 0.1 0.00068 19.1 0.0 2.1 2 0 0 2 2 2 2 Signal recognition particle receptor beta subunit G-alpha PF00503.20 EXF74931.1 - 1.6e-08 34.1 2.8 0.0002 20.6 0.5 2.8 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 EXF74931.1 - 2.7e-08 33.4 0.2 1.8e-07 30.7 0.2 1.9 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region Ras PF00071.22 EXF74931.1 - 1.6e-07 31.1 0.0 1.7e-05 24.5 0.0 2.0 2 0 0 2 2 2 2 Ras family MMR_HSR1 PF01926.23 EXF74931.1 - 0.0073 16.4 0.0 0.023 14.8 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.18 EXF74931.1 - 0.077 12.3 0.1 0.12 11.7 0.1 1.2 1 0 0 1 1 1 0 6-phosphofructo-2-kinase DUF1325 PF07039.11 EXF74932.1 - 2.6e-34 118.2 0.0 3.9e-34 117.6 0.0 1.3 1 0 0 1 1 1 1 SGF29 tudor-like domain Tudor_3 PF18115.1 EXF74932.1 - 0.036 13.9 0.0 0.11 12.4 0.0 1.8 2 0 0 2 2 2 0 DNA repair protein Crb2 Tudor domain PMI_typeI PF01238.21 EXF74933.1 - 6.7e-138 459.9 0.0 7.8e-138 459.7 0.0 1.0 1 0 0 1 1 1 1 Phosphomannose isomerase type I Zn_clus PF00172.18 EXF74934.1 - 2.5e-08 33.9 5.5 3.9e-08 33.3 5.5 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Macoilin PF09726.9 EXF74934.1 - 5.1 5.5 4.6 9.6 4.6 4.6 1.4 1 0 0 1 1 1 0 Macoilin family Zn_clus PF00172.18 EXF74935.1 - 0.0032 17.6 12.4 0.014 15.5 12.4 2.0 1 1 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EXF74935.1 - 0.0064 15.5 0.9 0.014 14.5 0.9 1.6 1 1 0 1 1 1 1 Fungal specific transcription factor domain BLOC1_2 PF10046.9 EXF74935.1 - 0.051 13.9 0.3 0.12 12.7 0.3 1.5 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 PRKG1_interact PF15898.5 EXF74935.1 - 0.087 13.7 0.1 7.1 7.6 0.0 2.3 2 0 0 2 2 2 0 cGMP-dependent protein kinase interacting domain MFS_1 PF07690.16 EXF74936.1 - 7.4e-23 81.0 34.3 1.1e-21 77.2 30.9 2.3 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF1129 PF06570.11 EXF74936.1 - 0.44 10.0 0.0 0.44 10.0 0.0 2.7 4 0 0 4 4 4 0 Protein of unknown function (DUF1129) DHDPS PF00701.22 EXF74937.1 - 8.6e-21 73.9 0.0 1.3e-20 73.3 0.0 1.3 1 1 0 1 1 1 1 Dihydrodipicolinate synthetase family DUF3830 PF12903.7 EXF74938.1 - 2e-27 95.7 0.0 2.4e-27 95.4 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3830) TauD PF02668.16 EXF74939.1 - 4.2e-44 151.3 0.5 5.4e-44 151.0 0.5 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Colipase PF01114.18 EXF74940.1 - 0.0083 15.8 0.4 0.0083 15.8 0.4 2.1 2 0 0 2 2 2 1 Colipase, N-terminal domain Cupin_1 PF00190.22 EXF74942.1 - 5.1e-07 29.4 0.0 7.5e-07 28.9 0.0 1.3 1 0 0 1 1 1 1 Cupin Cupin_2 PF07883.11 EXF74942.1 - 2.2e-05 24.1 2.6 3.1e-05 23.6 0.8 2.1 2 1 0 2 2 2 1 Cupin domain Auxin_BP PF02041.16 EXF74942.1 - 0.014 15.1 0.0 0.014 15.0 0.0 1.2 1 0 0 1 1 1 0 Auxin binding protein AA_permease PF00324.21 EXF74943.1 - 5.3e-59 200.1 28.2 5e-40 137.5 13.3 2.0 1 1 1 2 2 2 2 Amino acid permease AA_permease_2 PF13520.6 EXF74943.1 - 1.8e-15 56.7 29.4 2.5e-11 43.1 13.7 2.1 1 1 1 2 2 2 2 Amino acid permease CTV_P6 PF06706.11 EXF74943.1 - 0.094 12.4 0.1 0.37 10.5 0.1 2.1 1 0 0 1 1 1 0 Citrus tristeza virus 6-kDa protein DUF4381 PF14316.6 EXF74943.1 - 3.7 7.8 6.4 23 5.2 5.8 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4381) FMO-like PF00743.19 EXF74944.1 - 2.1e-10 39.6 0.0 4.3e-10 38.6 0.0 1.5 2 0 0 2 2 2 1 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 EXF74944.1 - 3.4e-10 39.7 0.0 7.8e-09 35.2 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EXF74944.1 - 7.1e-09 35.8 0.1 5.7e-08 32.9 0.0 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 EXF74944.1 - 4.4e-08 32.7 0.0 1.9e-07 30.7 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EXF74944.1 - 3e-05 23.3 0.0 0.0015 17.8 0.0 2.8 2 1 1 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Lycopene_cycl PF05834.12 EXF74944.1 - 4.1e-05 22.8 0.0 0.00096 18.3 0.0 2.7 2 1 0 2 2 2 1 Lycopene cyclase protein DAO PF01266.24 EXF74944.1 - 0.0001 22.1 0.0 0.001 18.8 0.0 2.3 2 0 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.17 EXF74944.1 - 0.00015 21.1 0.0 0.00031 20.1 0.0 1.4 1 0 0 1 1 1 1 Thi4 family NAD_binding_9 PF13454.6 EXF74944.1 - 0.00025 21.1 0.8 0.019 14.9 0.0 3.3 3 1 0 3 3 3 1 FAD-NAD(P)-binding Pyr_redox PF00070.27 EXF74944.1 - 0.002 18.7 0.5 0.2 12.2 0.2 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Shikimate_DH PF01488.20 EXF74944.1 - 0.0022 18.1 0.0 1 9.4 0.0 2.3 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.19 EXF74944.1 - 0.0074 15.7 0.0 0.02 14.2 0.0 1.7 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain FAD_binding_2 PF00890.24 EXF74944.1 - 0.0092 15.1 0.0 0.015 14.4 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain GIDA PF01134.22 EXF74944.1 - 0.015 14.4 0.0 0.61 9.1 0.1 2.1 2 0 0 2 2 2 0 Glucose inhibited division protein A HI0933_like PF03486.14 EXF74944.1 - 0.021 13.6 0.1 0.044 12.5 0.1 1.5 1 0 0 1 1 1 0 HI0933-like protein NAD_binding_2 PF03446.15 EXF74944.1 - 0.031 14.4 0.0 8.5 6.5 0.0 2.2 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase FAD_binding_3 PF01494.19 EXF74944.1 - 0.12 11.7 0.0 0.12 11.7 0.0 1.6 2 0 0 2 2 2 0 FAD binding domain F420_oxidored PF03807.17 EXF74944.1 - 0.13 12.8 0.0 14 6.3 0.0 2.7 3 0 0 3 3 3 0 NADP oxidoreductase coenzyme F420-dependent DpnI_C PF17726.1 EXF74944.1 - 0.16 12.1 0.2 0.56 10.4 0.0 1.9 2 0 0 2 2 2 0 Dam-replacing HTH domain NAD_binding_7 PF13241.6 EXF74944.1 - 0.19 12.2 0.0 22 5.6 0.0 2.4 2 0 0 2 2 2 0 Putative NAD(P)-binding ThiF PF00899.21 EXF74944.1 - 0.21 10.9 0.1 2.5 7.4 0.0 2.1 2 0 0 2 2 2 0 ThiF family TrkA_N PF02254.18 EXF74944.1 - 0.45 10.8 0.9 5.7 7.2 0.2 2.4 2 0 0 2 2 2 0 TrkA-N domain CoA_transf_3 PF02515.17 EXF74945.1 - 1.4e-39 136.3 0.3 2.7e-39 135.3 0.2 1.5 2 0 0 2 2 2 1 CoA-transferase family III 3HCDH_N PF02737.18 EXF74946.1 - 1.1e-45 155.7 0.0 1.5e-45 155.2 0.0 1.2 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 EXF74946.1 - 1.8e-15 57.3 0.0 3.6e-15 56.3 0.0 1.6 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 2-Hacid_dh_C PF02826.19 EXF74946.1 - 0.001 18.4 0.1 0.0042 16.5 0.1 2.0 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.14 EXF74946.1 - 0.0017 18.0 0.0 0.0026 17.3 0.0 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_Gly3P_dh_N PF01210.23 EXF74946.1 - 0.019 15.0 0.1 0.076 13.0 0.1 2.0 1 1 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus ApbA PF02558.16 EXF74946.1 - 0.029 14.0 0.1 0.057 13.1 0.1 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA AlaDh_PNT_C PF01262.21 EXF74946.1 - 0.076 12.3 0.1 0.16 11.3 0.1 1.5 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_3 PF01494.19 EXF74946.1 - 0.084 12.1 0.0 0.12 11.6 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain IlvN PF07991.12 EXF74946.1 - 0.14 11.7 0.1 1.6 8.2 0.0 2.1 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain NAD_binding_2 PF03446.15 EXF74946.1 - 0.14 12.3 1.1 0.21 11.7 0.0 2.0 2 1 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase Ldl_recept_b PF00058.17 EXF74947.1 - 1.7e-12 47.6 3.5 0.0014 19.1 0.1 5.4 6 0 0 6 6 6 3 Low-density lipoprotein receptor repeat class B SGL PF08450.12 EXF74947.1 - 0.00018 21.2 0.4 0.24 11.0 0.1 2.7 1 1 0 2 2 2 2 SMP-30/Gluconolactonase/LRE-like region DUF5074 PF16819.5 EXF74947.1 - 0.00071 19.6 0.0 0.0054 16.8 0.1 2.5 2 1 1 3 3 3 1 Domain of unknown function (DUF5074) Str_synth PF03088.16 EXF74947.1 - 0.026 14.7 0.3 6.7 6.9 0.0 3.2 2 1 0 3 3 3 0 Strictosidine synthase He_PIG PF05345.12 EXF74947.1 - 0.056 13.6 0.0 8.7 6.6 0.0 3.2 3 0 0 3 3 3 0 Putative Ig domain EHN PF06441.12 EXF74948.1 - 1.1e-28 99.7 0.1 2.1e-28 98.8 0.1 1.5 1 0 0 1 1 1 1 Epoxide hydrolase N terminus Abhydrolase_1 PF00561.20 EXF74948.1 - 3.5e-07 30.1 0.0 6.1e-07 29.3 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold NAD_binding_10 PF13460.6 EXF74949.1 - 7.9e-12 45.4 0.0 3e-11 43.5 0.0 1.9 1 1 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EXF74949.1 - 1.4e-09 37.9 0.0 2e-09 37.4 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family Epimerase PF01370.21 EXF74949.1 - 2.9e-08 33.5 0.2 0.00032 20.3 0.1 2.3 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 EXF74949.1 - 0.01 15.0 0.2 0.58 9.2 0.0 2.1 2 0 0 2 2 2 0 RmlD substrate binding domain KR PF08659.10 EXF74949.1 - 0.024 14.6 0.0 0.039 13.9 0.0 1.3 1 0 0 1 1 1 0 KR domain DUF2816 PF10992.8 EXF74949.1 - 0.12 12.3 0.2 0.32 10.9 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2816) Alpha-L-AF_C PF06964.12 EXF74950.1 - 2.4e-27 96.1 0.1 3.7e-27 95.5 0.1 1.2 1 0 0 1 1 1 1 Alpha-L-arabinofuranosidase C-terminal domain Aldo_ket_red PF00248.21 EXF74951.1 - 4.5e-58 196.8 0.0 5e-58 196.6 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Rx_N PF18052.1 EXF74952.1 - 0.039 14.2 0.1 0.23 11.7 0.0 2.3 2 0 0 2 2 2 0 Rx N-terminal domain Cu_amine_oxid PF01179.20 EXF74953.1 - 7.4e-153 509.3 0.0 8.9e-153 509.0 0.0 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN2 PF02727.16 EXF74953.1 - 2.4e-06 27.7 0.0 4.1e-06 26.9 0.0 1.4 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain Cu_amine_oxidN3 PF02728.16 EXF74953.1 - 0.00012 22.4 0.0 0.0003 21.2 0.0 1.6 1 0 0 1 1 1 1 Copper amine oxidase, N3 domain adh_short_C2 PF13561.6 EXF74954.1 - 2.8e-53 180.9 1.8 3.3e-53 180.7 1.8 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF74954.1 - 7.6e-48 162.6 2.4 1e-47 162.2 2.4 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EXF74954.1 - 4.6e-20 72.3 1.2 6e-20 71.9 1.2 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EXF74954.1 - 6.1e-05 22.6 1.1 0.00043 19.8 1.1 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EXF74954.1 - 0.011 15.1 0.0 0.67 9.3 0.1 2.2 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase THF_DHG_CYH_C PF02882.19 EXF74954.1 - 0.012 14.9 0.0 0.022 14.1 0.0 1.5 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Cas_Cas02710 PF09670.10 EXF74954.1 - 0.054 12.3 0.0 0.075 11.8 0.0 1.2 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Cas02710) Fungal_trans_2 PF11951.8 EXF74955.1 - 0.00015 20.7 1.0 0.00015 20.7 1.0 1.4 1 1 0 1 1 1 1 Fungal specific transcription factor domain PhyH PF05721.13 EXF74956.1 - 1.7e-22 80.7 0.2 2.3e-22 80.3 0.2 1.1 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) Brix PF04427.18 EXF74957.1 - 1.4e-45 155.8 0.0 1.9e-45 155.4 0.0 1.2 1 0 0 1 1 1 1 Brix domain DUF4647 PF15504.6 EXF74957.1 - 0.0093 15.1 5.0 0.014 14.5 5.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4647) ANAPC_CDC26 PF10471.9 EXF74957.1 - 8 7.4 9.8 2.5 9.0 5.3 2.4 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit CDC26 DEAD PF00270.29 EXF74958.1 - 3.2e-46 157.3 0.0 5.2e-46 156.6 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EXF74958.1 - 1.9e-30 105.5 0.3 9.3e-30 103.2 0.1 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EXF74958.1 - 1.3e-05 25.3 0.0 2.9e-05 24.1 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Trypan_PARP PF05887.11 EXF74958.1 - 6 6.9 10.4 0.45 10.5 2.2 2.2 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) Kinesin PF00225.23 EXF74959.1 - 8.4e-56 189.3 0.0 1.3e-55 188.7 0.0 1.3 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EXF74959.1 - 1.4e-11 44.6 0.0 5.1e-09 36.2 0.0 2.4 2 0 0 2 2 2 2 Microtubule binding NRBF2 PF08961.10 EXF74959.1 - 2.4 7.7 10.3 0.045 13.4 1.4 2.3 2 0 0 2 2 2 0 Nuclear receptor-binding factor 2, autophagy regulator Herpes_BLRF2 PF05812.12 EXF74959.1 - 3.3 7.9 6.9 0.25 11.5 1.0 2.1 2 0 0 2 2 2 0 Herpesvirus BLRF2 protein HsbA PF12296.8 EXF74961.1 - 1e-26 93.7 5.5 1e-26 93.7 5.5 1.5 2 0 0 2 2 2 1 Hydrophobic surface binding protein A TFIIB PF00382.19 EXF74962.1 - 6.7e-34 115.8 9.8 7.6e-20 70.7 0.1 2.9 3 0 0 3 3 3 2 Transcription factor TFIIB repeat BRF1 PF07741.13 EXF74962.1 - 4.1e-25 88.1 0.9 4.1e-25 88.1 0.9 3.4 4 0 0 4 4 4 1 Brf1-like TBP-binding domain Cyclin_N PF00134.23 EXF74962.1 - 3.5e-07 30.0 0.9 0.019 14.7 0.1 2.4 2 0 0 2 2 2 2 Cyclin, N-terminal domain Thioredoxin PF00085.20 EXF74962.1 - 0.087 12.8 0.0 0.19 11.7 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin DUF1213 PF06740.12 EXF74962.1 - 6.6 7.4 7.8 3.3 8.4 2.2 2.9 1 1 2 3 3 2 0 Protein of unknown function (DUF1213) DUF1349 PF07081.11 EXF74963.1 - 8.7e-28 97.2 1.1 1.1e-27 97.0 1.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1349) Peptidase_S24 PF00717.23 EXF74965.1 - 2.3e-07 30.7 0.0 3.4e-07 30.1 0.0 1.4 1 0 0 1 1 1 1 Peptidase S24-like DHHC PF01529.20 EXF74966.1 - 5.5 7.1 8.2 1.4e+02 2.5 0.0 3.3 2 1 0 2 2 2 0 DHHC palmitoyltransferase BTB PF00651.31 EXF74968.1 - 7.5e-08 32.6 0.0 2e-07 31.2 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain Rubella_E2 PF05749.11 EXF74968.1 - 0.02 14.3 2.7 0.038 13.5 0.1 2.1 2 0 0 2 2 2 0 Rubella membrane glycoprotein E2 Skp1_POZ PF03931.15 EXF74968.1 - 0.13 12.4 0.0 0.59 10.4 0.0 2.0 2 0 0 2 2 2 0 Skp1 family, tetramerisation domain PRIMA1 PF16101.5 EXF74968.1 - 0.15 12.1 1.0 5.2 7.1 0.6 2.7 3 0 0 3 3 3 0 Proline-rich membrane anchor 1 Abhydrolase_1 PF00561.20 EXF74969.1 - 1.8e-09 37.6 0.0 5.9e-09 35.9 0.0 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EXF74969.1 - 6.1e-08 33.5 3.2 1.7e-06 28.8 3.2 2.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EXF74969.1 - 1.7e-05 24.3 0.0 0.0021 17.4 0.0 2.3 2 0 0 2 2 2 2 Serine aminopeptidase, S33 ATP-synt_E PF05680.12 EXF74969.1 - 0.1 12.9 0.0 0.67 10.3 0.0 2.3 2 0 0 2 2 2 0 ATP synthase E chain DLH PF01738.18 EXF74969.1 - 0.2 11.2 0.0 0.35 10.4 0.0 1.3 1 0 0 1 1 1 0 Dienelactone hydrolase family FA_hydroxylase PF04116.13 EXF74970.1 - 3.4e-09 37.1 1.5 3.4e-09 37.1 1.5 2.1 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily DUF3808 PF10300.9 EXF74971.1 - 5.5e-129 431.0 0.7 6.8e-129 430.7 0.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3808) HrpB1_HrpK PF09613.10 EXF74971.1 - 0.022 14.4 3.6 0.026 14.2 1.8 2.0 2 0 0 2 2 2 0 Bacterial type III secretion protein (HrpB1_HrpK) TPR_10 PF13374.6 EXF74971.1 - 0.072 13.0 3.7 0.58 10.1 0.1 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 EXF74971.1 - 0.15 12.6 12.5 2.3 8.8 0.7 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 EXF74971.1 - 0.19 11.9 6.1 11 6.4 0.0 5.5 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_12 PF13424.6 EXF74971.1 - 0.81 10.0 0.0 0.81 10.0 0.0 4.4 6 0 0 6 6 6 0 Tetratricopeptide repeat PTS_IIA PF02255.16 EXF74971.1 - 1.1 9.3 6.0 3.3 7.8 0.3 3.7 2 1 1 3 3 3 0 PTS system, Lactose/Cellobiose specific IIA subunit TPR_4 PF07721.14 EXF74971.1 - 1.4 9.8 0.0 1.4 9.8 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_16 PF13432.6 EXF74971.1 - 1.8 9.3 10.2 4.5 8.0 0.1 4.8 5 0 0 5 5 5 0 Tetratricopeptide repeat UQ_con PF00179.26 EXF74972.1 - 8.9e-44 148.5 0.0 1.2e-43 148.2 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EXF74972.1 - 0.00026 20.7 0.0 0.0004 20.1 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic E2 family B DUF4597 PF15366.6 EXF74972.1 - 0.0066 16.2 1.4 0.0093 15.7 0.3 1.8 1 1 1 2 2 2 1 Domain of unknown function (DUF4597) UEV PF05743.13 EXF74972.1 - 0.025 14.4 0.0 0.041 13.8 0.0 1.4 1 0 0 1 1 1 0 UEV domain RWD PF05773.22 EXF74972.1 - 0.083 13.2 0.0 0.12 12.7 0.0 1.5 1 1 0 1 1 1 0 RWD domain RabGAP-TBC PF00566.18 EXF74973.1 - 7.5e-38 130.3 1.8 2e-21 76.6 0.0 3.7 3 1 0 3 3 3 2 Rab-GTPase-TBC domain ABC_tran PF00005.27 EXF74974.1 - 1.1e-48 165.3 0.7 1e-22 81.2 0.0 3.3 3 0 0 3 3 3 2 ABC transporter ABC_tran_Xtn PF12848.7 EXF74974.1 - 1.8e-20 72.8 7.9 1.8e-20 72.8 7.9 3.7 5 0 0 5 5 4 1 ABC transporter AAA_21 PF13304.6 EXF74974.1 - 2.3e-17 63.8 1.1 0.0014 18.5 0.0 4.5 3 1 0 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EXF74974.1 - 2.5e-11 43.4 1.7 0.0039 16.7 0.0 4.5 4 0 0 4 4 4 4 RecF/RecN/SMC N terminal domain AAA_30 PF13604.6 EXF74974.1 - 3.4e-07 30.2 0.1 0.0011 18.7 0.1 3.6 3 1 0 3 3 3 1 AAA domain MMR_HSR1 PF01926.23 EXF74974.1 - 5.1e-07 29.8 0.1 0.016 15.3 0.0 2.9 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_18 PF13238.6 EXF74974.1 - 1.1e-06 29.2 0.2 0.045 14.3 0.0 3.2 3 0 0 3 3 2 2 AAA domain AAA_29 PF13555.6 EXF74974.1 - 2.2e-06 27.3 0.2 0.055 13.2 0.0 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EXF74974.1 - 5.7e-06 26.3 1.6 0.11 12.3 0.1 3.2 2 1 0 3 3 3 2 RsgA GTPase AAA_23 PF13476.6 EXF74974.1 - 6.2e-06 26.9 17.2 0.0043 17.6 0.1 4.7 5 0 0 5 5 5 2 AAA domain AAA_16 PF13191.6 EXF74974.1 - 9.3e-06 26.1 1.6 0.016 15.6 0.1 2.9 3 0 0 3 3 2 2 AAA ATPase domain AAA_33 PF13671.6 EXF74974.1 - 3.1e-05 24.2 0.0 0.25 11.5 0.0 2.9 2 0 0 2 2 2 2 AAA domain AAA_24 PF13479.6 EXF74974.1 - 5e-05 23.1 1.5 0.56 9.9 0.0 3.5 3 0 0 3 3 3 2 AAA domain AAA_22 PF13401.6 EXF74974.1 - 9.5e-05 22.7 0.1 0.55 10.5 0.1 3.1 3 1 0 3 3 2 2 AAA domain AAA PF00004.29 EXF74974.1 - 0.00018 21.9 0.0 0.13 12.7 0.0 3.0 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 EXF74974.1 - 0.00046 20.5 2.5 0.14 12.4 0.0 2.9 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.6 EXF74974.1 - 0.00051 20.1 0.3 1.7 8.7 0.0 3.2 3 0 0 3 3 2 2 AAA domain MeaB PF03308.16 EXF74974.1 - 0.0019 17.2 0.3 2.2 7.2 0.0 2.9 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB RNA_helicase PF00910.22 EXF74974.1 - 0.003 17.9 0.0 1.8 9.0 0.0 2.6 2 0 0 2 2 2 1 RNA helicase NACHT PF05729.12 EXF74974.1 - 0.0036 17.2 0.1 4.3 7.2 0.0 2.6 2 0 0 2 2 2 1 NACHT domain NTPase_1 PF03266.15 EXF74974.1 - 0.0053 16.7 0.1 0.61 10.0 0.1 2.7 2 0 0 2 2 2 1 NTPase cobW PF02492.19 EXF74974.1 - 0.006 16.2 0.6 1.2 8.7 0.5 2.6 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_7 PF12775.7 EXF74974.1 - 0.0066 16.0 0.0 3.7 7.0 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region Roc PF08477.13 EXF74974.1 - 0.0078 16.4 0.1 5.6 7.2 0.0 2.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_15 PF13175.6 EXF74974.1 - 0.0097 15.7 0.6 0.095 12.4 0.2 4.7 4 1 1 5 5 5 2 AAA ATPase domain Dynamin_N PF00350.23 EXF74974.1 - 0.012 15.6 7.2 0.78 9.8 0.0 4.1 4 1 0 4 4 4 0 Dynamin family MobB PF03205.14 EXF74974.1 - 0.015 15.2 0.6 0.3 11.0 0.2 2.4 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_5 PF07728.14 EXF74974.1 - 0.021 14.8 0.3 7 6.6 0.0 3.1 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) NB-ARC PF00931.22 EXF74974.1 - 0.022 14.0 0.1 3.3 6.8 0.0 2.5 2 0 0 2 2 2 0 NB-ARC domain ATP-synt_ab PF00006.25 EXF74974.1 - 0.049 13.3 0.1 4.7 6.8 0.0 2.5 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain Rad17 PF03215.15 EXF74974.1 - 0.054 13.4 0.1 4.8 7.1 0.0 3.1 3 0 0 3 3 3 0 Rad17 P-loop domain 5_3_exonuc_N PF02739.16 EXF74974.1 - 0.06 13.3 0.0 0.96 9.3 0.0 2.4 2 0 0 2 2 2 0 5'-3' exonuclease, N-terminal resolvase-like domain SRP54 PF00448.22 EXF74974.1 - 0.063 12.9 1.9 3.8 7.1 0.0 3.5 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain Zeta_toxin PF06414.12 EXF74974.1 - 0.072 12.4 1.1 3.1 7.0 0.1 3.2 3 0 0 3 3 3 0 Zeta toxin TsaE PF02367.17 EXF74974.1 - 0.079 13.0 0.0 4.7 7.2 0.0 2.6 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE GTP_EFTU PF00009.27 EXF74974.1 - 0.14 11.7 1.4 16 5.0 0.0 3.3 3 0 0 3 3 3 0 Elongation factor Tu GTP binding domain DUF87 PF01935.17 EXF74974.1 - 0.26 11.3 7.5 0.71 9.9 0.0 3.6 4 0 0 4 4 4 0 Helicase HerA, central domain DUF4647 PF15504.6 EXF74974.1 - 0.45 9.6 3.8 8.9 5.3 0.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4647) ATP_bind_1 PF03029.17 EXF74974.1 - 0.5 10.1 1.8 35 4.1 0.2 3.0 3 0 0 3 3 2 0 Conserved hypothetical ATP binding protein AAA_17 PF13207.6 EXF74974.1 - 1 9.8 7.1 21 5.5 0.3 3.8 4 0 0 4 4 3 0 AAA domain AAA_27 PF13514.6 EXF74974.1 - 6.4 6.3 0.0 5 6.7 0.0 3.9 6 0 0 6 6 4 0 AAA domain Tubulin PF00091.25 EXF74975.1 - 1.6e-68 230.8 0.0 4.3e-68 229.4 0.0 1.6 2 0 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EXF74975.1 - 8.9e-43 145.5 0.1 1.4e-42 144.8 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 EXF74975.1 - 1.5e-05 25.3 0.0 5.4e-05 23.5 0.0 1.9 2 0 0 2 2 2 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.6 EXF74975.1 - 0.0039 16.9 0.0 0.0071 16.0 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain Tubulin_2 PF13809.6 EXF74975.1 - 0.0046 16.2 0.0 0.024 13.8 0.0 1.9 2 0 0 2 2 2 1 Tubulin like Ribosomal_L6 PF00347.23 EXF74976.1 - 9.2e-21 74.3 0.0 1.1e-08 35.6 0.0 3.2 2 2 1 3 3 3 2 Ribosomal protein L6 Inositol_P PF00459.25 EXF74977.1 - 2.4e-49 168.3 2.3 5.6e-49 167.1 2.3 1.5 1 1 0 1 1 1 1 Inositol monophosphatase family DUF2630 PF10944.8 EXF74977.1 - 0.0039 17.6 0.1 0.0076 16.7 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2630) SopA_C PF13979.6 EXF74977.1 - 0.064 13.0 0.1 0.11 12.3 0.1 1.3 1 0 0 1 1 1 0 SopA-like catalytic domain Complex1_LYR_2 PF13233.6 EXF74978.1 - 1.6e-22 80.0 0.2 2.2e-22 79.6 0.2 1.2 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR PF05347.15 EXF74978.1 - 0.029 14.4 1.3 0.057 13.5 0.9 1.8 1 1 1 2 2 2 0 Complex 1 protein (LYR family) Aha1_N PF09229.11 EXF74980.1 - 6.2e-42 143.1 0.7 1.3e-41 142.1 0.7 1.5 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal AHSA1 PF08327.11 EXF74980.1 - 6.9e-18 65.1 0.3 1.5e-17 64.0 0.3 1.6 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein DHHC PF01529.20 EXF74981.1 - 2.6e-31 108.5 1.6 2.6e-31 108.5 1.6 2.8 2 1 1 3 3 3 1 DHHC palmitoyltransferase Rap1_C PF11626.8 EXF74982.1 - 1.4e-21 76.3 0.9 1.9e-20 72.7 0.0 3.0 3 0 0 3 3 3 1 TRF2-interacting telomeric protein/Rap1 - C terminal domain Myb_DNA-bind_2 PF08914.11 EXF74982.1 - 5.4e-15 55.3 5.6 4.2e-12 46.1 0.2 3.1 3 0 0 3 3 3 2 Rap1 Myb domain BRCT_2 PF16589.5 EXF74982.1 - 6.9e-11 42.4 0.0 1.3e-10 41.5 0.0 1.5 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain Rap1-DNA-bind PF09197.10 EXF74982.1 - 5e-07 30.3 2.3 0.012 16.2 0.2 3.0 2 0 0 2 2 2 2 Rap1, DNA-binding ARID PF01388.21 EXF74982.1 - 3.3e-06 27.7 0.1 9e-06 26.3 0.1 1.8 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain CN_hydrolase PF00795.22 EXF74983.1 - 1e-31 110.3 0.0 1.5e-31 109.7 0.0 1.2 1 1 0 1 1 1 1 Carbon-nitrogen hydrolase LysM PF01476.20 EXF74984.1 - 0.0034 17.4 0.0 0.0049 16.9 0.0 1.3 1 0 0 1 1 1 1 LysM domain HLH PF00010.26 EXF74985.1 - 2.8e-16 59.2 0.0 6e-16 58.1 0.0 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain SLX9 PF15341.6 EXF74985.1 - 1.9 8.9 9.9 0.72 10.2 5.9 2.2 2 1 1 3 3 3 0 Ribosome biogenesis protein SLX9 Peptidase_M24 PF00557.24 EXF74986.1 - 1.4e-48 165.3 0.0 2.2e-48 164.7 0.0 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 EXF74986.1 - 1.8e-38 131.0 0.0 2.8e-38 130.4 0.0 1.3 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain DUF5539 PF17693.1 EXF74986.1 - 0.33 10.6 3.0 0.66 9.6 3.0 1.6 1 1 0 1 1 1 0 Family of unknown function (DUF5539) Dfp1_Him1_M PF08630.10 EXF74987.1 - 2e-37 128.2 0.0 6.1e-37 126.7 0.0 1.9 1 0 0 1 1 1 1 Dfp1/Him1, central region zf-DBF PF07535.12 EXF74987.1 - 6.4e-22 77.4 0.6 1.3e-21 76.4 0.6 1.5 1 0 0 1 1 1 1 DBF zinc finger Tropomyosin_1 PF12718.7 EXF74987.1 - 0.022 14.9 0.3 0.074 13.2 0.3 1.9 1 0 0 1 1 1 0 Tropomyosin like Lyase_aromatic PF00221.19 EXF74988.1 - 1.6e-152 508.4 1.5 2.1e-152 508.0 1.5 1.1 1 0 0 1 1 1 1 Aromatic amino acid lyase APG12 PF04110.13 EXF74989.1 - 5.1e-28 97.3 0.0 6.4e-28 97.0 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Atg8 PF02991.16 EXF74989.1 - 8.2e-07 29.2 0.0 1e-06 28.9 0.0 1.2 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like Pantoate_transf PF02548.15 EXF74990.1 - 3e-106 354.6 0.2 3.5e-106 354.4 0.2 1.0 1 0 0 1 1 1 1 Ketopantoate hydroxymethyltransferase PEP_mutase PF13714.6 EXF74990.1 - 1.7e-09 37.5 0.5 3.4e-09 36.5 0.1 1.6 2 0 0 2 2 2 1 Phosphoenolpyruvate phosphomutase DUF4861 PF16153.5 EXF74990.1 - 0.016 14.2 0.0 0.023 13.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4861) UQ_con PF00179.26 EXF74991.1 - 7.2e-34 116.4 0.1 8.3e-34 116.2 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme DUF572 PF04502.13 EXF74992.1 - 1.5e-70 238.5 0.0 1.8e-70 238.2 0.0 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF572) FlgN PF05130.12 EXF74992.1 - 0.045 14.3 1.3 0.12 12.9 1.3 1.7 1 0 0 1 1 1 0 FlgN protein Fungal_trans PF04082.18 EXF74993.1 - 5.1e-21 74.9 0.1 9.9e-21 74.0 0.1 1.5 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF74993.1 - 0.0087 16.2 7.3 0.016 15.3 7.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SIR2 PF02146.17 EXF74994.1 - 2.2e-39 135.2 0.0 4.5e-39 134.2 0.0 1.5 1 1 0 1 1 1 1 Sir2 family TPP_enzyme_M PF00205.22 EXF74994.1 - 0.039 13.7 0.0 1.6 8.4 0.0 2.4 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain DUF1936 PF09151.10 EXF74994.1 - 0.68 9.9 2.1 26 4.8 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1936) ADH_zinc_N PF00107.26 EXF74995.1 - 1.4e-22 80.0 0.0 2.5e-22 79.3 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EXF74995.1 - 5.6e-20 71.2 6.5 9.4e-20 70.5 6.5 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 EXF74995.1 - 1.2e-07 32.9 0.0 1.9e-07 32.2 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 EXF74995.1 - 0.00024 20.5 0.6 0.00045 19.6 0.4 1.5 1 1 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.19 EXF74995.1 - 0.0041 16.5 0.4 0.0065 15.9 0.4 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Gag_MA PF01140.19 EXF74995.1 - 0.008 15.9 0.0 0.017 14.8 0.0 1.6 1 0 0 1 1 1 1 Matrix protein (MA), p15 Glyco_hydro_16 PF00722.21 EXF74996.1 - 9.5e-46 155.5 1.3 9.5e-46 155.5 1.3 1.6 2 0 0 2 2 2 1 Glycosyl hydrolases family 16 Macoilin PF09726.9 EXF74996.1 - 1 7.8 9.3 1.3 7.5 9.3 1.1 1 0 0 1 1 1 0 Macoilin family Abhydrolase_2 PF02230.16 EXF74997.1 - 1.1e-26 94.0 0.0 1.3e-09 38.2 0.0 3.1 3 0 0 3 3 3 3 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.21 EXF74997.1 - 0.00021 20.8 0.0 0.00049 19.6 0.0 1.8 1 1 0 1 1 1 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 EXF74997.1 - 0.011 15.0 0.0 0.22 10.7 0.0 2.4 2 1 0 2 2 2 0 Serine aminopeptidase, S33 DLH PF01738.18 EXF74997.1 - 0.041 13.4 0.0 0.068 12.7 0.0 1.3 1 0 0 1 1 1 0 Dienelactone hydrolase family FSH1 PF03959.13 EXF74997.1 - 0.23 11.1 0.1 2.1 7.9 0.1 2.2 1 1 0 1 1 1 0 Serine hydrolase (FSH1) DHDPS PF00701.22 EXF74998.1 - 2.7e-35 121.5 0.0 3.6e-35 121.1 0.0 1.1 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family Toxin_ToxA PF11584.8 EXF74998.1 - 0.15 12.1 0.0 0.34 10.9 0.0 1.6 1 0 0 1 1 1 0 Proteinaceous host-selective toxin ToxA Tyrosinase PF00264.20 EXF74999.1 - 1.6e-38 133.2 0.0 2.2e-38 132.8 0.0 1.2 1 0 0 1 1 1 1 Common central domain of tyrosinase Tyosinase_C PF18132.1 EXF74999.1 - 0.00056 20.6 0.0 0.0076 16.9 0.0 2.3 1 1 0 1 1 1 1 Tyosinase C-terminal domain MFS_5 PF05631.14 EXF75000.1 - 7.1e-70 235.7 4.0 1e-69 235.2 4.0 1.1 1 0 0 1 1 1 1 Sugar-tranasporters, 12 TM MFS_1 PF07690.16 EXF75000.1 - 4e-23 81.9 28.0 4e-23 81.9 28.0 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF75000.1 - 1.7e-06 27.2 1.6 1.7e-06 27.2 1.6 3.2 1 1 1 3 3 3 2 Sugar (and other) transporter DUF2678 PF10856.8 EXF75000.1 - 1.3 9.0 5.8 1.2 9.1 0.1 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF2678) Glyco_hydro_92N PF17678.1 EXF75001.1 - 1.9e-56 191.6 0.0 2.4e-56 191.3 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 N-terminal domain Glyco_hydro_92 PF07971.12 EXF75001.1 - 1.9e-16 60.1 0.0 2.5e-16 59.7 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 Glyco_hydro_92 PF07971.12 EXF75002.1 - 1.6e-110 370.2 0.1 1.9e-110 370.0 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 zf-primase PF09329.11 EXF75003.1 - 3e-18 65.3 2.2 5.6e-18 64.5 2.2 1.5 1 0 0 1 1 1 1 Primase zinc finger tRNA_anti-codon PF01336.25 EXF75003.1 - 0.084 12.9 0.0 0.18 11.8 0.0 1.5 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain RNase_H2-Ydr279 PF09468.10 EXF75004.1 - 1.3e-41 142.5 0.2 1.3e-41 142.5 0.2 1.9 2 0 0 2 2 2 1 Ydr279p protein family (RNase H2 complex component) wHTH domain Ydr279_N PF17745.1 EXF75004.1 - 3.1e-24 85.0 0.0 7.8e-24 83.7 0.0 1.7 1 0 0 1 1 1 1 Ydr279p protein triple barrel domain DASH_Duo1 PF08651.10 EXF75005.1 - 4.2e-32 109.7 1.1 6.1e-32 109.2 1.1 1.2 1 0 0 1 1 1 1 DASH complex subunit Duo1 DUF1682 PF07946.14 EXF75005.1 - 0.092 11.9 3.8 0.1 11.8 3.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) DUF1035 PF06281.12 EXF75005.1 - 0.21 11.6 0.1 0.36 10.9 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1035) API5 PF05918.11 EXF75005.1 - 1.3 7.7 5.1 1.5 7.5 5.1 1.1 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) TTL PF03133.15 EXF75007.1 - 6.1e-54 183.1 0.0 9.3e-54 182.5 0.0 1.2 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family SurE PF01975.17 EXF75007.1 - 2.9e-52 177.3 0.0 4.4e-52 176.7 0.0 1.3 1 0 0 1 1 1 1 Survival protein SurE ATPgrasp_YheCD PF14398.6 EXF75007.1 - 0.00012 21.4 0.0 0.00026 20.3 0.0 1.5 1 0 0 1 1 1 1 YheC/D like ATP-grasp DUF4611 PF15387.6 EXF75007.1 - 5.4 7.3 7.9 3.2 8.0 2.3 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) Cation_ATPase_C PF00689.21 EXF75009.1 - 2e-42 145.0 7.8 2e-42 145.0 7.8 2.3 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 EXF75009.1 - 1.2e-34 119.4 1.7 1.2e-34 119.4 1.7 2.9 3 1 0 3 3 3 1 E1-E2 ATPase Cation_ATPase PF13246.6 EXF75009.1 - 4.9e-22 77.8 0.0 9.7e-22 76.9 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EXF75009.1 - 5.8e-20 72.5 0.6 2e-19 70.7 0.6 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EXF75009.1 - 4.2e-06 26.7 0.6 1.9e-05 24.5 0.4 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EXF75009.1 - 0.00012 21.7 0.0 0.0017 18.0 0.0 2.6 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus HAD PF12710.7 EXF75009.1 - 0.14 12.5 0.0 0.29 11.5 0.0 1.5 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase SIR2 PF02146.17 EXF75010.1 - 1.9e-62 210.3 0.0 3.2e-62 209.6 0.0 1.4 1 0 0 1 1 1 1 Sir2 family DUF592 PF04574.13 EXF75010.1 - 1e-05 25.4 0.0 2.6e-05 24.1 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF592) TPP_enzyme_M PF00205.22 EXF75010.1 - 4.6e-05 23.2 0.1 0.043 13.6 0.1 2.6 3 0 0 3 3 3 2 Thiamine pyrophosphate enzyme, central domain zf-4CXXC_R1 PF10497.9 EXF75010.1 - 0.012 15.8 0.5 0.026 14.8 0.5 1.5 1 0 0 1 1 1 0 Zinc-finger domain of monoamine-oxidase A repressor R1 Pkinase PF00069.25 EXF75011.1 - 1.2e-15 57.6 0.0 6.2e-15 55.3 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF75011.1 - 1.1e-09 38.0 0.0 2.1e-08 33.8 0.0 2.4 1 1 0 1 1 1 1 Protein tyrosine kinase DCB PF16213.5 EXF75011.1 - 0.065 12.9 0.4 0.18 11.5 0.0 1.9 2 0 0 2 2 2 0 Dimerisation and cyclophilin-binding domain of Mon2 Aminotran_4 PF01063.19 EXF75012.1 - 3.2e-33 115.5 0.0 4e-33 115.2 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV ESSS PF10183.9 EXF75013.1 - 3.5e-11 43.2 0.0 4.8e-11 42.8 0.0 1.3 1 1 0 1 1 1 1 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) Dna2 PF08696.11 EXF75014.1 - 6.1e-71 238.4 0.2 6.1e-71 238.4 0.2 2.1 2 1 0 2 2 2 1 DNA replication factor Dna2 AAA_12 PF13087.6 EXF75014.1 - 1.3e-51 175.1 0.0 2.9e-51 174.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 EXF75014.1 - 1.1e-31 110.6 8.6 1.6e-17 64.2 0.0 3.3 3 1 1 4 4 3 2 AAA domain AAA_30 PF13604.6 EXF75014.1 - 9.8e-14 51.5 0.0 2.3e-13 50.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EXF75014.1 - 2.1e-12 47.6 0.1 5.8e-12 46.2 0.1 1.9 1 0 0 1 1 1 1 AAA domain Cas_Cas4 PF01930.17 EXF75014.1 - 6.7e-11 42.6 1.2 3.5e-08 33.7 0.2 2.4 2 0 0 2 2 2 2 Domain of unknown function DUF83 Viral_helicase1 PF01443.18 EXF75014.1 - 6.8e-07 29.3 0.2 0.31 10.7 0.0 3.5 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase PDDEXK_1 PF12705.7 EXF75014.1 - 2.2e-06 27.8 0.1 4.4e-06 26.8 0.1 1.6 1 0 0 1 1 1 1 PD-(D/E)XK nuclease superfamily Helicase_RecD PF05127.14 EXF75014.1 - 0.00011 22.1 0.1 0.00048 20.0 0.0 2.1 2 1 0 2 2 2 1 Helicase SRP54 PF00448.22 EXF75014.1 - 0.0014 18.3 0.1 0.0028 17.3 0.1 1.5 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain UvrD-helicase PF00580.21 EXF75014.1 - 0.0015 18.2 0.0 0.0015 18.2 0.0 2.2 3 0 0 3 3 2 1 UvrD/REP helicase N-terminal domain PIF1 PF05970.14 EXF75014.1 - 0.0019 17.4 0.1 0.014 14.6 0.1 2.1 1 1 0 1 1 1 1 PIF1-like helicase AAA_16 PF13191.6 EXF75014.1 - 0.0066 16.8 1.4 0.012 16.0 0.0 2.2 2 0 0 2 2 1 1 AAA ATPase domain CbiA PF01656.23 EXF75014.1 - 0.0079 16.3 0.0 0.019 15.0 0.0 1.6 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain Csa1 PF06023.12 EXF75014.1 - 0.017 14.5 0.3 0.042 13.2 0.3 1.6 1 1 0 1 1 1 0 CRISPR-associated exonuclease Csa1 AAA_7 PF12775.7 EXF75014.1 - 0.03 13.8 0.0 0.069 12.7 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region ResIII PF04851.15 EXF75014.1 - 0.04 13.9 0.0 0.12 12.3 0.0 1.8 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit DUF87 PF01935.17 EXF75014.1 - 0.065 13.3 1.9 0.12 12.4 0.2 2.4 3 0 0 3 3 2 0 Helicase HerA, central domain cobW PF02492.19 EXF75014.1 - 0.079 12.5 0.0 0.21 11.1 0.0 1.7 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain NTPase_1 PF03266.15 EXF75014.1 - 0.092 12.7 0.2 0.24 11.3 0.2 1.6 1 0 0 1 1 1 0 NTPase AAA_25 PF13481.6 EXF75014.1 - 0.093 12.3 0.1 0.38 10.3 0.0 2.0 2 0 0 2 2 2 0 AAA domain MeaB PF03308.16 EXF75014.1 - 0.12 11.3 0.0 0.26 10.3 0.0 1.4 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB MobB PF03205.14 EXF75014.1 - 0.13 12.1 0.1 0.69 9.8 0.0 2.2 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_18 PF13238.6 EXF75014.1 - 0.14 12.7 0.1 0.55 10.8 0.0 2.0 2 0 0 2 2 1 0 AAA domain McrBC PF10117.9 EXF75015.1 - 0.029 13.5 0.1 0.048 12.8 0.1 1.2 1 0 0 1 1 1 0 McrBC 5-methylcytosine restriction system component LTXXQ PF07813.12 EXF75015.1 - 2.3 9.0 15.0 5.2 7.8 2.1 2.5 2 0 0 2 2 2 0 LTXXQ motif family protein F-box-like PF12937.7 EXF75016.1 - 1e-06 28.5 0.1 3.4e-06 26.8 0.1 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EXF75016.1 - 6.1e-05 22.8 0.1 0.00012 21.8 0.1 1.5 1 0 0 1 1 1 1 F-box domain p450 PF00067.22 EXF75017.1 - 6e-37 127.5 0.0 2.6e-36 125.3 0.0 2.0 3 0 0 3 3 3 1 Cytochrome P450 Aim21 PF11489.8 EXF75018.1 - 2.7e-183 611.7 85.3 2.7e-183 611.7 85.3 2.3 3 0 0 3 3 3 1 Altered inheritance of mitochondria protein 21 Cg6151-P PF10233.9 EXF75019.1 - 5.1e-41 139.5 16.1 6.1e-41 139.3 16.1 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein CG6151-P OCD_Mu_crystall PF02423.15 EXF75021.1 - 5.8e-11 41.9 0.1 3.7e-06 26.1 0.0 2.8 3 0 0 3 3 3 2 Ornithine cyclodeaminase/mu-crystallin family Shikimate_DH PF01488.20 EXF75021.1 - 0.1 12.6 0.0 5.6 7.0 0.0 2.7 3 0 0 3 3 3 0 Shikimate / quinate 5-dehydrogenase Usp PF00582.26 EXF75023.1 - 5.4e-23 82.1 5.0 4.6e-15 56.4 0.3 2.8 3 0 0 3 3 3 2 Universal stress protein family Ribosomal_S7 PF00177.21 EXF75024.1 - 6e-25 87.6 0.0 1.1e-24 86.8 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e dsrm PF00035.26 EXF75025.1 - 0.0026 18.4 0.0 0.0037 17.9 0.0 1.2 1 0 0 1 1 1 1 Double-stranded RNA binding motif DND1_DSRM PF14709.7 EXF75025.1 - 0.015 15.6 0.0 0.061 13.6 0.0 1.9 1 1 0 1 1 1 0 double strand RNA binding domain from DEAD END PROTEIN 1 DUF2850 PF11012.8 EXF75025.1 - 0.15 12.4 0.0 0.22 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2850) PhyH PF05721.13 EXF75026.1 - 0.16 12.2 0.0 0.22 11.8 0.0 1.2 1 0 0 1 1 1 0 Phytanoyl-CoA dioxygenase (PhyH) PUMA PF15826.5 EXF75028.1 - 0.069 13.3 1.1 0.12 12.6 1.1 1.3 1 0 0 1 1 1 0 Bcl-2-binding component 3, p53 upregulated modulator of apoptosis tRNA_int_end_N2 PF12928.7 EXF75029.1 - 1e-20 73.7 0.3 2e-20 72.7 0.3 1.5 1 0 0 1 1 1 1 tRNA-splicing endonuclease subunit sen54 N-term G6PD_bact PF10786.9 EXF75029.1 - 0.015 14.8 0.9 0.51 9.8 0.1 2.2 2 0 0 2 2 2 0 Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49) tRNA_int_endo_N PF02778.14 EXF75029.1 - 0.066 12.9 0.2 0.17 11.6 0.2 1.6 1 0 0 1 1 1 0 tRNA intron endonuclease, N-terminal domain GSDH PF07995.11 EXF75032.1 - 0.18 11.1 1.1 1 8.6 1.1 2.2 1 1 0 1 1 1 0 Glucose / Sorbosone dehydrogenase WD40 PF00400.32 EXF75033.1 - 1.9e-21 75.9 22.4 1.1e-05 26.0 0.2 7.0 6 2 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EXF75033.1 - 9.3e-13 48.3 5.1 2.3e-05 24.6 0.0 4.1 2 2 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain TFIIIC_delta PF12657.7 EXF75033.1 - 3.6e-05 23.8 8.6 0.014 15.3 0.2 3.1 2 2 0 2 2 2 2 Transcription factor IIIC subunit delta N-term IKI3 PF04762.12 EXF75033.1 - 0.85 7.5 3.0 4.8 5.1 0.0 2.1 2 0 0 2 2 2 0 IKI3 family bZIP_2 PF07716.15 EXF75035.1 - 8.7e-06 25.7 7.9 2e-05 24.6 7.9 1.6 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 EXF75035.1 - 1.8e-05 24.7 5.4 4.3e-05 23.5 5.4 1.5 1 0 0 1 1 1 1 bZIP transcription factor TTKRSYEDQ PF10212.9 EXF75035.1 - 0.013 14.5 0.1 0.021 13.9 0.1 1.2 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein Glyco_hydro_127 PF07944.12 EXF75036.1 - 2e-136 455.5 0.4 2.3e-136 455.3 0.4 1.0 1 0 0 1 1 1 1 Beta-L-arabinofuranosidase, GH127 Lactamase_B PF00753.27 EXF75037.1 - 7.1e-14 52.3 0.4 1.2e-13 51.5 0.4 1.3 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EXF75037.1 - 2.9e-05 23.7 0.1 5.7e-05 22.7 0.1 1.4 1 1 0 1 1 1 1 Beta-lactamase superfamily domain PH_6 PF15406.6 EXF75037.1 - 0.014 15.7 0.0 0.031 14.5 0.0 1.6 1 0 0 1 1 1 0 Pleckstrin homology domain Oxidored_FMN PF00724.20 EXF75038.1 - 1.3e-44 152.9 0.0 1.6e-44 152.6 0.0 1.1 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Dus PF01207.17 EXF75038.1 - 3.3e-06 26.4 0.0 1.1e-05 24.7 0.0 1.7 1 1 1 2 2 2 1 Dihydrouridine synthase (Dus) AP_endonuc_2 PF01261.24 EXF75038.1 - 0.0016 17.9 0.0 0.52 9.7 0.0 2.8 1 1 1 2 2 2 2 Xylose isomerase-like TIM barrel MTHFR PF02219.17 EXF75038.1 - 0.14 11.5 0.0 0.22 10.8 0.0 1.2 1 0 0 1 1 1 0 Methylenetetrahydrofolate reductase Glyco_hydro_16 PF00722.21 EXF75039.1 - 7.6e-09 35.3 0.0 1e-08 34.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 SKN1 PF03935.15 EXF75039.1 - 2.9e-06 26.0 1.3 0.0079 14.6 2.6 2.1 2 0 0 2 2 2 2 Beta-glucan synthesis-associated protein (SKN1) Acetyltransf_2 PF00797.17 EXF75040.1 - 2.3e-38 132.3 0.1 2.3e-37 129.1 0.1 2.2 1 1 0 1 1 1 1 N-acetyltransferase Transglut_core PF01841.19 EXF75040.1 - 0.0065 16.9 0.0 0.18 12.3 0.0 2.5 2 0 0 2 2 2 1 Transglutaminase-like superfamily EphA2_TM PF14575.6 EXF75041.1 - 2e-05 25.3 0.1 4.7e-05 24.2 0.0 1.6 2 0 0 2 2 1 1 Ephrin type-A receptor 2 transmembrane domain Shisa PF13908.6 EXF75041.1 - 8.1e-05 23.0 0.0 9.6e-05 22.7 0.0 1.1 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator ETRAMP PF09716.10 EXF75041.1 - 0.00085 19.3 3.5 0.0015 18.5 3.5 1.4 1 0 0 1 1 1 1 Malarial early transcribed membrane protein (ETRAMP) Protocadherin PF08374.11 EXF75041.1 - 0.0037 17.3 0.1 0.0047 16.9 0.1 1.1 1 0 0 1 1 1 1 Protocadherin FAM163 PF15069.6 EXF75041.1 - 0.0045 17.5 0.2 0.0057 17.1 0.2 1.2 1 0 0 1 1 1 1 FAM163 family RCR PF12273.8 EXF75041.1 - 0.0085 16.7 6.1 0.043 14.5 6.1 2.0 1 1 0 1 1 1 1 Chitin synthesis regulation, resistance to Congo red ASPRs PF17641.2 EXF75041.1 - 0.0091 16.3 0.2 0.013 15.7 0.2 1.2 1 0 0 1 1 1 1 Ancylostoma-associated secreted protein related DUF1218 PF06749.12 EXF75041.1 - 0.011 16.2 0.2 0.014 15.9 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1218) SIT PF15330.6 EXF75041.1 - 0.016 15.7 0.0 0.028 14.9 0.0 1.5 1 1 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT Imm59 PF15597.6 EXF75041.1 - 0.03 14.8 0.1 0.046 14.2 0.1 1.2 1 0 0 1 1 1 0 Immunity protein 59 TMEM154 PF15102.6 EXF75041.1 - 0.042 13.8 0.0 0.074 13.0 0.0 1.4 1 0 0 1 1 1 0 TMEM154 protein family TMEM52 PF14979.6 EXF75041.1 - 0.054 13.4 0.0 0.064 13.2 0.0 1.2 1 0 0 1 1 1 0 Transmembrane 52 DUF4446 PF14584.6 EXF75041.1 - 0.063 13.3 0.0 0.098 12.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) VirionAssem_T7 PF11653.8 EXF75041.1 - 0.071 13.6 2.8 0.071 13.6 2.8 1.6 2 0 0 2 2 1 0 Bacteriophage T7 virion assembly protein Cadherin_C_2 PF16492.5 EXF75041.1 - 0.083 13.7 1.7 0.14 12.9 1.7 1.5 1 1 0 1 1 1 0 Cadherin cytoplasmic C-terminal LAS2 PF15792.5 EXF75041.1 - 0.12 12.9 1.3 0.19 12.3 1.3 1.2 1 0 0 1 1 1 0 Lung adenoma susceptibility protein 2 Comm PF15957.5 EXF75041.1 - 0.24 11.8 2.6 0.34 11.3 2.6 1.3 1 1 0 1 1 1 0 Commissureless DAG1 PF05454.11 EXF75041.1 - 0.63 9.4 2.7 0.79 9.0 2.4 1.3 1 1 0 1 1 1 0 Dystroglycan (Dystrophin-associated glycoprotein 1) ECSCR PF15820.5 EXF75041.1 - 1 9.2 6.6 0.36 10.7 3.2 1.8 1 1 0 2 2 2 0 Endothelial cell-specific chemotaxis regulator Peptidase_S8 PF00082.22 EXF75042.1 - 1.5e-33 116.3 1.3 1.5e-33 116.3 1.3 1.7 2 1 0 2 2 2 1 Subtilase family Tetradecapep PF08187.11 EXF75043.1 - 0.094 12.8 0.1 0.34 11.0 0.1 2.0 1 0 0 1 1 1 0 Myoactive tetradecapeptides family Amino_oxidase PF01593.24 EXF75045.1 - 3.2e-58 198.1 0.0 7.4e-58 196.9 0.0 1.6 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase Clr5 PF14420.6 EXF75045.1 - 3e-13 49.8 3.0 1.3e-12 47.7 3.0 2.2 1 0 0 1 1 1 1 Clr5 domain NAD_binding_8 PF13450.6 EXF75045.1 - 1.5e-09 37.9 0.0 4.5e-09 36.4 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 EXF75045.1 - 0.0026 16.9 0.1 0.0049 16.0 0.1 1.4 1 0 0 1 1 1 1 Glucose inhibited division protein A Pyr_redox_2 PF07992.14 EXF75045.1 - 0.0031 16.8 0.0 0.054 12.7 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EXF75045.1 - 0.015 14.6 0.5 0.03 13.6 0.2 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EXF75045.1 - 0.018 15.6 0.4 0.23 12.1 0.1 2.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EXF75045.1 - 0.036 13.3 0.1 0.059 12.6 0.1 1.3 1 0 0 1 1 1 0 FAD binding domain Thi4 PF01946.17 EXF75045.1 - 0.041 13.1 0.1 0.078 12.2 0.1 1.3 1 0 0 1 1 1 0 Thi4 family FAD_binding_2 PF00890.24 EXF75045.1 - 0.057 12.5 0.6 0.09 11.8 0.6 1.3 1 0 0 1 1 1 0 FAD binding domain FAD_oxidored PF12831.7 EXF75045.1 - 0.085 12.2 0.1 0.17 11.2 0.1 1.5 1 0 0 1 1 1 0 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.21 EXF75045.1 - 0.2 10.9 0.1 0.39 10.0 0.1 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain DUF2781 PF10914.8 EXF75047.1 - 5.4e-36 124.2 10.0 6.6e-36 123.9 10.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2781) p450 PF00067.22 EXF75048.1 - 1.3e-70 238.5 0.0 1.6e-70 238.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 MFS_1 PF07690.16 EXF75049.1 - 6.1e-46 157.0 25.3 6.1e-46 157.0 25.3 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF75049.1 - 1.3e-09 37.5 9.4 1.3e-09 37.5 9.4 1.9 1 1 1 2 2 2 1 Sugar (and other) transporter MFS_3 PF05977.13 EXF75049.1 - 0.00064 18.2 2.3 0.00086 17.8 2.3 1.2 1 0 0 1 1 1 1 Transmembrane secretion effector CDC50 PF03381.15 EXF75050.1 - 8.4e-74 248.6 0.1 1.4e-73 247.9 0.0 1.4 1 1 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family DUF2157 PF09925.9 EXF75050.1 - 0.032 14.0 0.0 0.075 12.8 0.0 1.5 2 0 0 2 2 2 0 Predicted membrane protein (DUF2157) PhoLip_ATPase_C PF16212.5 EXF75051.1 - 3.3e-46 158.1 4.0 3.3e-46 158.1 4.0 2.0 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EXF75051.1 - 2e-23 81.8 0.2 2e-23 81.8 0.2 1.8 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal E1-E2_ATPase PF00122.20 EXF75051.1 - 3.6e-11 42.9 0.0 8.3e-11 41.7 0.0 1.5 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase PF13246.6 EXF75051.1 - 5.8e-11 42.3 0.0 5.6e-10 39.2 0.0 2.3 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EXF75051.1 - 1.8e-09 38.2 0.0 0.00027 21.3 0.0 3.3 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EXF75051.1 - 0.0074 16.0 0.3 0.019 14.7 0.0 1.7 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HCV_NS5a_1b PF08301.13 EXF75051.1 - 0.07 13.7 0.1 0.18 12.4 0.1 1.6 1 0 0 1 1 1 0 Hepatitis C virus non-structural 5a domain 1b PBP PF01161.20 EXF75052.1 - 2.1e-11 44.3 0.0 3.3e-11 43.6 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein DUF1075 PF06388.11 EXF75052.1 - 0.16 12.0 0.0 0.28 11.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1075) NAD_binding_10 PF13460.6 EXF75053.1 - 9.5e-07 28.9 0.0 1.1e-06 28.6 0.0 1.1 1 0 0 1 1 1 1 NAD(P)H-binding Fungal_trans_2 PF11951.8 EXF75054.1 - 1.8e-44 152.1 0.5 2.6e-44 151.6 0.5 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF75054.1 - 1.1e-06 28.6 4.1 2.4e-06 27.5 4.1 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Peptidase_S8 PF00082.22 EXF75055.1 - 4.1e-39 134.6 0.2 6.7e-39 133.9 0.2 1.3 1 0 0 1 1 1 1 Subtilase family ADH_zinc_N PF00107.26 EXF75055.1 - 6.5e-22 77.9 0.4 2.4e-21 76.1 0.0 2.2 3 0 0 3 3 3 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EXF75055.1 - 1.7e-20 72.9 3.1 4.6e-20 71.5 3.1 1.8 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain fn3_5 PF06280.12 EXF75055.1 - 1.1e-19 71.2 0.1 2.4e-19 70.1 0.1 1.6 1 0 0 1 1 1 1 Fn3-like domain ADH_zinc_N_2 PF13602.6 EXF75055.1 - 4.7e-07 30.9 0.0 1.7e-06 29.1 0.0 1.9 2 0 0 2 2 2 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 EXF75055.1 - 2.7e-06 26.8 0.1 6e-06 25.7 0.1 1.5 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.19 EXF75055.1 - 0.00072 19.0 0.1 0.0015 17.9 0.1 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Asn_synthase PF00733.21 EXF75056.1 - 1.2e-68 232.4 0.0 1.8e-68 231.8 0.0 1.3 1 0 0 1 1 1 1 Asparagine synthase GATase_7 PF13537.6 EXF75056.1 - 7.3e-35 119.6 0.0 1.2e-34 118.9 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 EXF75056.1 - 6.9e-34 116.9 0.0 1.4e-33 115.9 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain DUF3700 PF12481.8 EXF75056.1 - 8.8e-06 25.3 0.0 1.6e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Aluminium induced protein NAD_synthase PF02540.17 EXF75056.1 - 0.0041 16.3 0.0 0.0066 15.6 0.0 1.2 1 0 0 1 1 1 1 NAD synthase GFA PF04828.14 EXF75057.1 - 1.3e-23 83.2 0.1 1.7e-23 82.8 0.1 1.1 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme CTP_transf_like PF01467.26 EXF75058.1 - 0.033 14.4 0.0 0.16 12.2 0.0 2.1 2 0 0 2 2 2 0 Cytidylyltransferase-like Ribosomal_60s PF00428.19 EXF75058.1 - 0.19 12.4 5.3 0.44 11.2 5.3 1.6 1 0 0 1 1 1 0 60s Acidic ribosomal protein Med4 PF10018.9 EXF75058.1 - 0.4 10.3 3.5 0.72 9.5 3.5 1.3 1 0 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 Glycos_transf_1 PF00534.20 EXF75059.1 - 9e-34 116.5 0.0 1e-32 113.0 0.0 2.1 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 EXF75059.1 - 9.2e-17 61.5 0.0 1.6e-16 60.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_4 PF13692.6 EXF75059.1 - 2.6e-15 57.0 0.0 7.1e-15 55.6 0.0 1.8 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 EXF75059.1 - 7.7e-08 32.9 0.0 1.9e-07 31.7 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain ALG11_N PF15924.5 EXF75059.1 - 0.001 19.2 0.2 0.033 14.2 0.0 2.7 1 1 1 2 2 2 1 ALG11 mannosyltransferase N-terminus Glyco_trans_1_2 PF13524.6 EXF75059.1 - 0.012 15.9 0.0 0.027 14.9 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferases group 1 ECH_1 PF00378.20 EXF75060.1 - 1.6e-17 63.6 0.0 2e-17 63.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EXF75060.1 - 2e-07 30.9 0.0 2.5e-07 30.5 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Peptidase_S49 PF01343.18 EXF75060.1 - 0.0013 18.7 0.0 0.51 10.3 0.0 2.2 2 0 0 2 2 2 2 Peptidase family S49 RabGAP-TBC PF00566.18 EXF75061.1 - 2.7e-49 167.8 0.0 4.3e-49 167.1 0.0 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Filament PF00038.21 EXF75061.1 - 0.94 9.0 6.1 0.3 10.6 0.3 2.2 2 0 0 2 2 2 0 Intermediate filament protein LRR_4 PF12799.7 EXF75062.1 - 7.4e-25 86.6 40.3 7.3e-05 23.1 2.3 9.0 3 1 9 12 12 12 9 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EXF75062.1 - 1.1e-17 63.5 37.6 1e-08 34.8 2.2 7.1 3 3 6 9 9 9 8 Leucine rich repeat LRR_9 PF14580.6 EXF75062.1 - 1.6e-09 37.6 14.7 0.038 13.5 0.6 5.1 1 1 2 4 4 4 4 Leucine-rich repeat LRR_6 PF13516.6 EXF75062.1 - 5.1e-05 23.0 20.9 3 8.1 0.0 7.7 7 0 0 7 7 7 3 Leucine Rich repeat LRR_1 PF00560.33 EXF75062.1 - 0.12 13.0 27.2 35 5.5 0.5 9.6 9 1 0 9 9 9 0 Leucine Rich Repeat DUF1582 PF07621.11 EXF75065.1 - 0.54 10.2 3.9 1.4 8.9 3.9 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1582) IPK PF03770.16 EXF75066.1 - 1.1e-56 191.8 0.0 4.7e-56 189.8 0.0 1.9 2 0 0 2 2 2 1 Inositol polyphosphate kinase DAO PF01266.24 EXF75067.1 - 3.3e-33 115.7 7.7 5.7e-33 114.9 7.7 1.3 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EXF75067.1 - 0.08 13.2 0.5 0.27 11.5 0.5 1.9 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain HDV_ag PF01517.18 EXF75067.1 - 0.085 12.7 1.2 0.17 11.7 0.1 1.9 2 0 0 2 2 2 0 Hepatitis delta virus delta antigen DUF3784 PF12650.7 EXF75068.1 - 0.0092 16.2 0.9 0.017 15.3 0.9 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3784) DUF4407 PF14362.6 EXF75068.1 - 0.026 13.9 2.1 0.089 12.1 1.8 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) ABC_tran_CTD PF16326.5 EXF75068.1 - 0.027 14.7 0.1 0.089 13.1 0.1 1.9 1 0 0 1 1 1 0 ABC transporter C-terminal domain DUF373 PF04123.13 EXF75068.1 - 0.17 11.3 1.7 0.23 10.8 1.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF373) Swi5 PF07061.11 EXF75068.1 - 0.37 10.9 4.1 0.53 10.4 0.1 2.6 3 0 0 3 3 3 0 Swi5 CCDC-167 PF15188.6 EXF75068.1 - 1.5 9.2 4.0 1 9.7 0.6 2.5 2 1 0 2 2 2 0 Coiled-coil domain-containing protein 167 CN_hydrolase PF00795.22 EXF75071.1 - 3.9e-32 111.6 0.0 1.1e-31 110.1 0.0 1.7 1 1 0 1 1 1 1 Carbon-nitrogen hydrolase HATPase_c_3 PF13589.6 EXF75073.1 - 9.1e-15 54.7 0.0 1.6e-14 53.9 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase MutL_C PF08676.11 EXF75073.1 - 2.7e-10 40.2 0.0 3e-09 36.8 0.0 2.3 1 1 0 1 1 1 1 MutL C terminal dimerisation domain HATPase_c PF02518.26 EXF75073.1 - 0.0053 17.3 0.0 0.012 16.1 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase His_Phos_1 PF00300.22 EXF75074.1 - 9.2e-09 35.3 0.4 3.1e-08 33.5 0.4 1.8 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Calc_CGRP_IAPP PF00214.19 EXF75075.1 - 0.0022 18.3 0.1 0.0028 18.0 0.1 1.1 1 0 0 1 1 1 1 Calcitonin / CGRP / IAPP family Gastrin PF00918.17 EXF75075.1 - 0.0076 17.2 0.2 0.0097 16.9 0.2 1.1 1 0 0 1 1 1 1 Gastrin/cholecystokinin family HA2 PF04408.23 EXF75075.1 - 0.049 13.9 1.3 0.074 13.3 1.3 1.4 1 1 0 1 1 1 0 Helicase associated domain (HA2) PUCC PF03209.15 EXF75075.1 - 0.071 12.1 0.2 0.093 11.7 0.1 1.2 1 1 0 1 1 1 0 PUCC protein Connexin PF00029.19 EXF75075.1 - 0.11 12.3 0.1 0.13 12.0 0.1 1.1 1 0 0 1 1 1 0 Connexin SID-1_RNA_chan PF13965.6 EXF75075.1 - 0.3 9.4 0.0 0.34 9.3 0.0 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 GvpL_GvpF PF06386.11 EXF75075.1 - 1.2 9.0 8.3 1.4 8.8 8.3 1.0 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF Phage_Gp23 PF10669.9 EXF75075.1 - 9.5 6.6 9.1 65 3.9 9.0 1.9 1 1 0 1 1 1 0 Protein gp23 (Bacteriophage A118) Pec_lyase_C PF00544.19 EXF75076.1 - 1.7e-15 57.2 9.5 5.3e-14 52.3 9.5 2.2 1 1 0 1 1 1 1 Pectate lyase Beta_helix PF13229.6 EXF75076.1 - 3.4e-05 23.8 19.8 0.00024 21.0 10.8 2.3 1 1 1 2 2 2 2 Right handed beta helix region Phage_attach PF05354.11 EXF75076.1 - 0.045 13.6 0.1 0.13 12.1 0.1 1.7 1 0 0 1 1 1 0 Phage Head-Tail Attachment MFS_1 PF07690.16 EXF75077.1 - 5.8e-40 137.3 20.0 5.8e-40 137.3 20.0 1.9 2 0 0 2 2 2 1 Major Facilitator Superfamily DUF1772 PF08592.11 EXF75077.1 - 1.4 9.2 6.1 12 6.2 0.1 3.0 2 2 1 3 3 3 0 Domain of unknown function (DUF1772) Aldedh PF00171.22 EXF75080.1 - 1.1e-163 545.0 0.1 1.3e-163 544.8 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 EXF75080.1 - 0.021 14.3 0.0 0.13 11.6 0.0 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF1487) Thoc2 PF11732.8 EXF75080.1 - 0.15 12.1 0.0 0.35 10.9 0.0 1.6 1 0 0 1 1 1 0 Transcription- and export-related complex subunit Aminotran_3 PF00202.21 EXF75081.1 - 1.7e-116 389.3 0.0 1.9e-116 389.1 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Hydrolase PF00702.26 EXF75082.1 - 1.9e-05 25.1 0.0 4.1e-05 24.0 0.0 1.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EXF75082.1 - 0.072 13.2 0.0 0.083 13.0 0.0 1.3 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase DUF730 PF05325.11 EXF75082.1 - 0.16 12.0 0.1 0.27 11.2 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF730) DAO PF01266.24 EXF75083.1 - 8.2e-48 163.8 0.2 9.5e-48 163.6 0.2 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EXF75083.1 - 9.4e-06 25.1 0.1 0.0064 15.8 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EXF75083.1 - 4.6e-05 23.5 0.1 0.0031 17.5 0.1 2.5 2 0 0 2 2 2 1 FAD-NAD(P)-binding FAD_binding_2 PF00890.24 EXF75083.1 - 7.8e-05 21.9 0.4 0.16 11.0 0.1 2.1 2 0 0 2 2 2 2 FAD binding domain Thi4 PF01946.17 EXF75083.1 - 0.00014 21.1 0.0 0.00028 20.2 0.0 1.4 1 0 0 1 1 1 1 Thi4 family Pyr_redox_2 PF07992.14 EXF75083.1 - 0.00028 20.2 0.0 0.021 14.1 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 EXF75083.1 - 0.00028 20.3 0.0 0.0071 15.7 0.0 2.2 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EXF75083.1 - 0.00055 20.1 0.0 0.0015 18.7 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 EXF75083.1 - 0.0035 16.1 0.0 0.38 9.4 0.0 2.1 2 0 0 2 2 2 2 HI0933-like protein MCRA PF06100.11 EXF75083.1 - 0.028 13.2 0.0 0.048 12.5 0.0 1.3 1 0 0 1 1 1 0 MCRA family Lycopene_cycl PF05834.12 EXF75083.1 - 0.092 11.8 0.0 0.38 9.8 0.0 1.9 2 0 0 2 2 2 0 Lycopene cyclase protein Fungal_trans PF04082.18 EXF75084.1 - 6.6e-21 74.5 0.0 1e-20 73.9 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Oxidored_molyb PF00174.19 EXF75085.1 - 5.4e-49 166.1 0.0 9e-49 165.4 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain Mo-co_dimer PF03404.16 EXF75085.1 - 3.7e-20 72.3 2.0 7.1e-20 71.4 2.0 1.5 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain Na_Ca_ex PF01699.24 EXF75086.1 - 1.1e-21 77.3 30.3 4.7e-14 52.6 13.8 3.5 5 0 0 5 5 5 2 Sodium/calcium exchanger protein YccF PF03733.13 EXF75086.1 - 1.1e-16 61.3 11.4 1.1e-16 61.3 11.4 4.2 3 0 0 3 3 3 2 Inner membrane component domain AAA PF00004.29 EXF75087.1 - 7.7e-44 149.3 0.0 1.3e-43 148.6 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EXF75087.1 - 2.3e-14 52.9 0.0 4.3e-14 52.0 0.0 1.5 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 EXF75087.1 - 1.1e-07 31.9 0.0 2.7e-07 30.7 0.0 1.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 EXF75087.1 - 1.4e-07 31.8 0.0 2.6e-07 30.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 EXF75087.1 - 4.4e-06 27.2 0.0 0.00011 22.6 0.0 2.6 2 1 0 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 EXF75087.1 - 2.5e-05 24.5 0.2 0.006 16.9 0.2 2.4 1 1 0 1 1 1 1 AAA domain Prot_ATP_ID_OB PF16450.5 EXF75087.1 - 3.3e-05 23.8 2.7 8.8e-05 22.4 2.7 1.8 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain RuvB_N PF05496.12 EXF75087.1 - 5.8e-05 22.9 0.0 0.00011 22.0 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 EXF75087.1 - 0.00059 20.4 0.0 0.019 15.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain TIP49 PF06068.13 EXF75087.1 - 0.001 18.4 0.0 0.002 17.4 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_33 PF13671.6 EXF75087.1 - 0.0015 18.7 0.0 0.0029 17.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 EXF75087.1 - 0.0029 17.4 0.0 0.0052 16.5 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_3 PF07726.11 EXF75087.1 - 0.0032 17.3 0.0 0.01 15.7 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) ATPase PF06745.13 EXF75087.1 - 0.0061 15.9 0.1 0.019 14.3 0.0 1.8 2 0 0 2 2 2 1 KaiC Prot_ATP_OB_N PF17758.1 EXF75087.1 - 0.0073 15.9 0.1 0.024 14.3 0.1 1.9 1 0 0 1 1 1 1 Proteasomal ATPase OB N-terminal domain Mg_chelatase PF01078.21 EXF75087.1 - 0.008 15.6 0.0 0.017 14.5 0.0 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI TsaE PF02367.17 EXF75087.1 - 0.011 15.8 0.0 0.02 14.9 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_28 PF13521.6 EXF75087.1 - 0.011 15.9 0.0 0.02 15.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.13 EXF75087.1 - 0.021 14.0 0.0 0.038 13.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Sigma54_activat PF00158.26 EXF75087.1 - 0.023 14.4 0.0 0.097 12.4 0.0 2.0 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_7 PF12775.7 EXF75087.1 - 0.027 14.0 0.0 0.044 13.3 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region PhoH PF02562.16 EXF75087.1 - 0.029 13.8 0.0 0.14 11.6 0.0 2.0 2 0 0 2 2 2 0 PhoH-like protein AAA_24 PF13479.6 EXF75087.1 - 0.032 14.0 0.0 0.1 12.3 0.0 1.8 3 0 0 3 3 2 0 AAA domain RNA_helicase PF00910.22 EXF75087.1 - 0.034 14.5 0.0 0.064 13.6 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_14 PF13173.6 EXF75087.1 - 0.034 14.2 0.0 0.059 13.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain HR1 PF02185.16 EXF75087.1 - 0.052 13.7 1.0 0.13 12.4 1.0 1.6 1 0 0 1 1 1 0 Hr1 repeat AAA_25 PF13481.6 EXF75087.1 - 0.057 13.0 0.0 0.17 11.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain Parvo_NS1 PF01057.17 EXF75087.1 - 0.057 12.5 0.0 0.1 11.7 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 DUF2072 PF09845.9 EXF75087.1 - 0.062 13.6 0.1 0.12 12.6 0.1 1.5 1 0 0 1 1 1 0 Zn-ribbon containing protein Zeta_toxin PF06414.12 EXF75087.1 - 0.11 11.8 0.0 0.19 11.0 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin Y_phosphatase PF00102.27 EXF75088.1 - 2.3e-59 200.8 0.0 9.3e-51 172.7 0.0 3.2 2 1 0 2 2 2 2 Protein-tyrosine phosphatase Rhodanese PF00581.20 EXF75088.1 - 3.7e-12 46.7 0.0 1e-11 45.3 0.0 1.8 1 0 0 1 1 1 1 Rhodanese-like domain DSPc PF00782.20 EXF75088.1 - 0.025 14.4 0.1 0.056 13.3 0.1 1.5 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 EXF75088.1 - 0.056 13.4 0.2 0.12 12.4 0.2 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family MFS_1 PF07690.16 EXF75089.1 - 6.5e-10 38.5 17.4 6.5e-10 38.5 17.4 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily UNC-93 PF05978.16 EXF75089.1 - 3.3e-05 23.7 1.5 3.3e-05 23.7 1.5 2.7 3 0 0 3 3 3 1 Ion channel regulatory protein UNC-93 Sugar_tr PF00083.24 EXF75089.1 - 0.037 12.9 11.2 0.06 12.2 6.0 2.2 2 0 0 2 2 2 0 Sugar (and other) transporter PhyH PF05721.13 EXF75090.1 - 3.5e-09 37.2 0.1 8.9e-09 35.9 0.1 1.7 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) DUF1479 PF07350.12 EXF75090.1 - 9.4e-07 27.9 0.0 8e-05 21.6 0.0 2.7 2 1 0 2 2 2 2 Protein of unknown function (DUF1479) 2OG-FeII_Oxy_3 PF13640.6 EXF75090.1 - 0.018 15.9 0.0 0.036 15.0 0.0 1.5 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily 2-Hacid_dh_C PF02826.19 EXF75091.1 - 1.9e-43 147.9 0.0 9.8e-29 100.0 0.0 2.1 2 0 0 2 2 2 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.18 EXF75091.1 - 0.16 11.9 0.0 0.27 11.1 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain SnoaL_2 PF12680.7 EXF75093.1 - 0.00037 21.1 0.0 0.00064 20.3 0.0 1.4 1 1 0 1 1 1 1 SnoaL-like domain MFS_1 PF07690.16 EXF75094.1 - 5.6e-10 38.7 62.3 1.6e-07 30.6 31.7 2.5 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EXF75094.1 - 1.3e-05 23.8 19.3 2.2e-05 23.1 19.3 1.4 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Pox_A14 PF05767.12 EXF75094.1 - 2.7 8.2 7.7 0.54 10.4 2.2 2.7 2 0 0 2 2 2 0 Poxvirus virion envelope protein A14 Phage_TTP_1 PF04630.12 EXF75095.1 - 0.003 16.9 0.1 0.0035 16.7 0.1 1.3 1 0 0 1 1 1 1 Phage tail tube protein p450 PF00067.22 EXF75097.1 - 3.5e-76 256.8 0.0 4e-76 256.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Glyco_hydro_76 PF03663.14 EXF75098.1 - 9.5e-150 499.2 19.5 1.5e-149 498.5 19.5 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Fungal_trans PF04082.18 EXF75098.1 - 2.4e-21 76.0 0.0 4.2e-21 75.2 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF75098.1 - 2e-06 27.8 14.2 4e-06 26.9 14.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CemA PF03040.14 EXF75098.1 - 0.14 12.1 0.4 0.58 10.1 0.4 1.9 2 0 0 2 2 2 0 CemA family Glyco_hydro_88 PF07470.13 EXF75098.1 - 0.33 10.0 13.1 0.18 10.9 0.2 3.1 2 1 1 3 3 3 0 Glycosyl Hydrolase Family 88 NUDIX PF00293.28 EXF75099.1 - 1.1e-12 48.1 0.6 1.7e-12 47.5 0.6 1.2 1 0 0 1 1 1 1 NUDIX domain DUF4303 PF14136.6 EXF75099.1 - 0.014 15.1 1.8 0.022 14.5 1.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4303) PAN_4 PF14295.6 EXF75100.1 - 0.012 15.5 1.1 0.012 15.5 1.1 2.7 2 1 0 2 2 2 0 PAN domain Sh_2 PF17512.2 EXF75100.1 - 0.086 12.6 1.4 0.16 11.7 1.3 1.4 1 1 0 1 1 1 0 Metapneumovirus Small hydrophobic protein EIF4E-T PF10477.9 EXF75100.1 - 0.12 11.1 0.1 0.15 10.8 0.1 1.0 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E FAM217 PF15344.6 EXF75101.1 - 0.7 9.8 8.2 0.29 11.0 5.7 1.6 1 1 1 2 2 2 0 FAM217 family Pectate_lyase PF03211.13 EXF75103.1 - 1e-66 224.4 7.4 1.8e-66 223.6 7.4 1.3 1 0 0 1 1 1 1 Pectate lyase Coilin_N PF15862.5 EXF75103.1 - 2.7 7.8 13.2 4.1 7.2 13.2 1.2 1 0 0 1 1 1 0 Coilin N-terminus DIM PF08194.12 EXF75103.1 - 5.2 7.4 9.6 0.84 9.9 0.4 3.0 3 0 0 3 3 3 0 DIM protein PAP2 PF01569.21 EXF75104.1 - 5.4e-27 94.2 7.6 6.5e-27 93.9 2.5 2.2 2 0 0 2 2 2 2 PAP2 superfamily PAP2_C PF14360.6 EXF75104.1 - 0.36 11.4 8.7 0.062 13.8 3.6 2.4 2 1 0 2 2 2 0 PAP2 superfamily C-terminal Glyoxalase PF00903.25 EXF75105.1 - 2e-09 37.7 0.0 2.7e-09 37.3 0.0 1.2 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily ATP-synt_J PF04911.12 EXF75105.1 - 0.011 15.3 0.2 0.026 14.1 0.0 1.6 2 0 0 2 2 2 0 ATP synthase j chain Glyoxalase_6 PF18029.1 EXF75105.1 - 0.054 14.3 0.0 0.1 13.4 0.0 1.5 1 0 0 1 1 1 0 Glyoxalase-like domain zf-RVT PF13966.6 EXF75106.1 - 0.033 14.9 1.3 0.052 14.3 0.2 1.9 2 0 0 2 2 2 0 zinc-binding in reverse transcriptase UBM PF14377.6 EXF75107.1 - 0.079 12.4 0.2 2.6 7.6 0.2 2.7 2 0 0 2 2 2 0 Ubiquitin binding region Il2rg PF15874.5 EXF75107.1 - 0.17 12.2 0.0 15 5.9 0.1 2.4 2 0 0 2 2 2 0 Putative Interleukin 2 receptor, gamma chain GMC_oxred_N PF00732.19 EXF75109.1 - 2.3e-48 165.1 0.0 3e-48 164.7 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EXF75109.1 - 4.4e-37 127.8 0.0 1.2e-36 126.4 0.0 1.7 2 0 0 2 2 2 1 GMC oxidoreductase Lycopene_cycl PF05834.12 EXF75109.1 - 0.001 18.2 0.3 0.0019 17.3 0.3 1.4 1 0 0 1 1 1 1 Lycopene cyclase protein NAD_binding_8 PF13450.6 EXF75109.1 - 0.0013 18.9 0.4 0.0038 17.4 0.4 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EXF75109.1 - 0.0026 17.0 0.1 0.0053 16.0 0.1 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EXF75109.1 - 0.036 13.7 1.5 0.077 12.6 1.1 1.7 2 0 0 2 2 2 0 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EXF75109.1 - 0.068 12.2 1.4 0.11 11.5 1.4 1.3 1 0 0 1 1 1 0 FAD binding domain HI0933_like PF03486.14 EXF75109.1 - 0.12 11.0 0.3 0.48 9.1 0.1 1.8 2 0 0 2 2 2 0 HI0933-like protein HHH_5 PF14520.6 EXF75109.1 - 0.56 10.9 1.9 1.9 9.1 0.1 2.2 2 0 0 2 2 2 0 Helix-hairpin-helix domain Peptidase_S28 PF05577.12 EXF75110.1 - 1.6e-47 162.3 0.1 1.4e-38 132.8 0.0 2.0 2 0 0 2 2 2 2 Serine carboxypeptidase S28 PQ-loop PF04193.14 EXF75111.1 - 8.2e-23 79.9 3.3 4.3e-17 61.6 0.8 2.6 2 0 0 2 2 2 2 PQ loop repeat Cation_efflux PF01545.21 EXF75111.1 - 0.034 13.9 3.0 0.059 13.1 3.0 1.4 1 0 0 1 1 1 0 Cation efflux family Sigma_reg_C PF13791.6 EXF75111.1 - 0.042 14.1 0.0 0.073 13.3 0.0 1.3 1 0 0 1 1 1 0 Sigma factor regulator C-terminal DUF202 PF02656.15 EXF75111.1 - 7.5 7.1 10.9 0.98 9.9 1.3 3.3 3 1 0 3 3 3 0 Domain of unknown function (DUF202) Ada_Zn_binding PF02805.16 EXF75113.1 - 1.5e-26 92.2 2.1 2.3e-26 91.6 2.1 1.3 1 0 0 1 1 1 1 Metal binding domain of Ada HTH_18 PF12833.7 EXF75113.1 - 0.0013 18.9 0.7 0.0027 18.0 0.0 1.8 3 0 0 3 3 3 1 Helix-turn-helix domain HTH_AraC PF00165.23 EXF75113.1 - 0.0047 17.0 0.5 0.012 15.7 0.0 1.9 2 0 0 2 2 2 1 Bacterial regulatory helix-turn-helix proteins, AraC family TetR_N PF00440.23 EXF75113.1 - 0.11 12.4 0.1 0.18 11.6 0.1 1.4 1 0 0 1 1 1 0 Bacterial regulatory proteins, tetR family Sugar_tr PF00083.24 EXF75114.1 - 3.2e-82 276.8 15.2 3.6e-82 276.6 15.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF75114.1 - 5.5e-31 107.8 19.5 7.5e-31 107.3 19.5 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 EXF75114.1 - 2.3e-05 23.0 6.0 5.8e-05 21.7 1.8 2.1 2 0 0 2 2 2 2 Fungal trichothecene efflux pump (TRI12) Phage_holin_3_2 PF04550.12 EXF75114.1 - 0.019 15.5 1.4 0.077 13.5 1.4 2.1 1 0 0 1 1 1 0 Phage holin family 2 MFS_1 PF07690.16 EXF75116.1 - 1.1e-27 96.9 52.2 1.1e-22 80.5 32.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF4538 PF15061.6 EXF75116.1 - 0.16 11.8 0.6 10 5.9 0.0 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4538) p450 PF00067.22 EXF75117.1 - 3.1e-45 154.8 0.0 3e-26 92.2 0.0 3.0 3 0 0 3 3 3 3 Cytochrome P450 GMC_oxred_N PF00732.19 EXF75118.1 - 1.3e-52 179.0 0.0 1.7e-52 178.7 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EXF75118.1 - 6.2e-35 120.8 0.0 1e-34 120.1 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase Lycopene_cycl PF05834.12 EXF75118.1 - 0.0011 18.1 0.1 0.0022 17.1 0.1 1.4 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_2 PF07992.14 EXF75118.1 - 0.0012 18.1 1.0 0.38 9.9 0.0 2.6 2 1 1 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EXF75118.1 - 0.0071 16.6 0.2 0.023 14.9 0.2 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EXF75118.1 - 0.0092 15.6 0.9 0.053 13.1 0.1 2.3 2 0 0 2 2 2 1 FAD dependent oxidoreductase VKG_Carbox PF05090.14 EXF75118.1 - 0.21 10.4 0.1 0.31 9.8 0.1 1.1 1 0 0 1 1 1 0 Vitamin K-dependent gamma-carboxylase Hist_deacetyl PF00850.19 EXF75120.1 - 1.7e-81 274.1 0.0 2.5e-81 273.5 0.0 1.3 1 0 0 1 1 1 1 Histone deacetylase domain JAB PF01398.21 EXF75122.1 - 2.3e-32 111.4 0.0 4.8e-32 110.4 0.0 1.6 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 EXF75122.1 - 9.4e-12 45.3 0.4 2e-11 44.3 0.4 1.5 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function Prok-JAB PF14464.6 EXF75122.1 - 4.5e-07 29.7 0.0 8.1e-07 28.8 0.0 1.4 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain DUF4131 PF13567.6 EXF75124.1 - 2.3 7.8 4.7 0.41 10.3 0.7 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) Protamine_3 PF08188.11 EXF75125.1 - 0.081 13.1 2.8 0.16 12.2 2.8 1.5 1 0 0 1 1 1 0 Spermatozal protamine family DUF5644 PF18712.1 EXF75125.1 - 0.13 12.3 0.1 0.27 11.2 0.1 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5644) CHORD PF04968.12 EXF75127.1 - 0.012 16.3 0.1 0.012 16.3 0.1 2.7 2 1 0 2 2 2 0 CHORD DUF4267 PF14087.6 EXF75129.1 - 0.046 13.8 2.5 0.11 12.6 2.5 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4267) PAF-AH_p_II PF03403.13 EXF75130.1 - 7.3e-36 123.5 0.0 1.1e-35 122.9 0.0 1.1 1 0 0 1 1 1 1 Platelet-activating factor acetylhydrolase, isoform II Abhydrolase_6 PF12697.7 EXF75130.1 - 0.0012 19.5 0.6 0.0047 17.6 0.0 2.1 2 1 0 2 2 2 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EXF75130.1 - 0.033 13.4 0.5 0.61 9.3 0.0 2.6 2 1 1 3 3 3 0 Serine aminopeptidase, S33 Chlorophyllase2 PF12740.7 EXF75130.1 - 0.071 12.0 0.0 0.34 9.8 0.0 1.9 1 1 0 1 1 1 0 Chlorophyllase enzyme Abhydrolase_3 PF07859.13 EXF75130.1 - 0.12 12.3 0.0 0.26 11.1 0.0 1.5 1 0 0 1 1 1 0 alpha/beta hydrolase fold Cutinase PF01083.22 EXF75131.1 - 3.1e-48 164.1 4.9 3.7e-48 163.8 4.9 1.0 1 0 0 1 1 1 1 Cutinase VirJ PF06057.11 EXF75131.1 - 0.0014 18.6 0.0 0.0022 17.9 0.0 1.4 1 0 0 1 1 1 1 Bacterial virulence protein (VirJ) PE-PPE PF08237.11 EXF75131.1 - 0.0098 15.5 0.1 0.014 15.0 0.1 1.3 1 0 0 1 1 1 1 PE-PPE domain FSH1 PF03959.13 EXF75131.1 - 0.094 12.4 0.0 0.26 10.9 0.0 1.6 2 0 0 2 2 2 0 Serine hydrolase (FSH1) DUF4440 PF14534.6 EXF75134.1 - 9.4e-12 45.3 0.0 1.1e-11 45.0 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) PA26 PF04636.13 EXF75135.1 - 0.14 11.1 0.4 0.16 10.9 0.4 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) PPP4R2 PF09184.11 EXF75135.1 - 0.22 11.1 11.1 0.3 10.6 11.1 1.1 1 0 0 1 1 1 0 PPP4R2 SDA1 PF05285.12 EXF75135.1 - 0.37 10.2 13.8 0.47 9.8 13.8 1.1 1 0 0 1 1 1 0 SDA1 CDC45 PF02724.14 EXF75135.1 - 0.39 9.0 8.1 0.49 8.6 8.1 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF4746 PF15928.5 EXF75135.1 - 0.6 9.5 6.6 0.79 9.1 6.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Glypican PF01153.19 EXF75135.1 - 0.67 8.7 3.2 0.88 8.3 3.2 1.1 1 0 0 1 1 1 0 Glypican Nop14 PF04147.12 EXF75135.1 - 1.1 7.4 13.2 1.3 7.2 13.2 1.0 1 0 0 1 1 1 0 Nop14-like family CobT PF06213.12 EXF75135.1 - 1.8 7.9 15.3 2.7 7.3 15.3 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT JCAD PF15351.6 EXF75135.1 - 2 6.1 8.8 2.8 5.6 8.8 1.2 1 0 0 1 1 1 0 Junctional protein associated with coronary artery disease Presenilin PF01080.17 EXF75135.1 - 5.8 5.6 4.6 7.7 5.2 4.6 1.1 1 0 0 1 1 1 0 Presenilin DIOX_N PF14226.6 EXF75136.1 - 7.6e-19 68.6 0.0 1.5e-18 67.7 0.0 1.5 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EXF75136.1 - 3.6e-15 56.3 0.0 1.2e-14 54.6 0.0 1.8 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily HET PF06985.11 EXF75137.1 - 2.8e-20 73.2 0.0 7.4e-20 71.8 0.0 1.8 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Pkinase PF00069.25 EXF75137.1 - 5e-20 72.0 0.0 8.8e-20 71.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF75137.1 - 3.7e-10 39.5 0.0 6.4e-10 38.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EXF75138.1 - 1.2e-22 80.5 0.0 1.7e-22 80.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF75138.1 - 6.2e-13 48.6 0.0 9.3e-13 48.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Fungal_trans_2 PF11951.8 EXF75139.1 - 1.2e-58 198.8 0.4 1.2e-58 198.8 0.4 2.0 2 1 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF75139.1 - 1.3e-07 31.6 6.4 2.9e-07 30.5 6.4 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FAM163 PF15069.6 EXF75139.1 - 0.43 11.0 4.4 0.15 12.5 0.5 2.1 2 0 0 2 2 2 0 FAM163 family Fmp27 PF10344.9 EXF75140.1 - 1e-232 775.0 0.0 1.7e-232 774.2 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial protein from FMP27 Apt1 PF10351.9 EXF75140.1 - 5.4e-199 662.0 0.5 5.4e-199 662.0 0.5 3.0 3 0 0 3 3 3 1 Golgi-body localisation protein domain Fmp27_WPPW PF10359.9 EXF75140.1 - 1.7e-181 604.3 0.0 4.4e-181 603.0 0.0 1.8 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain DUF2405 PF10293.9 EXF75140.1 - 7.1e-57 191.7 0.1 2e-56 190.2 0.1 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF2405) Fmp27_GFWDK PF10347.9 EXF75140.1 - 3e-56 189.8 0.0 6e-56 188.9 0.0 1.5 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain Fmp27_SW PF10305.9 EXF75140.1 - 1.4e-32 112.4 0.0 1.1e-31 109.5 0.0 2.7 2 0 0 2 2 2 1 RNA pol II promoter Fmp27 protein domain JAB PF01398.21 EXF75142.1 - 4.7e-32 110.4 0.1 7.9e-32 109.7 0.1 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease CSN5_C PF18323.1 EXF75142.1 - 7.9e-26 90.8 0.2 1.5e-25 90.0 0.2 1.5 1 0 0 1 1 1 1 Cop9 signalosome subunit 5 C-terminal domain Prok-JAB PF14464.6 EXF75142.1 - 0.00012 21.8 0.0 0.00022 21.0 0.0 1.4 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain Polysacc_deac_1 PF01522.21 EXF75145.1 - 1.1e-14 54.4 0.0 2.1e-14 53.5 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide deacetylase 2_5_RNA_ligase2 PF13563.6 EXF75149.1 - 1.3e-28 99.8 0.1 3e-28 98.7 0.1 1.6 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily PAP_central PF04928.17 EXF75149.1 - 3.1e-20 72.2 0.0 5.9e-20 71.3 0.0 1.4 1 0 0 1 1 1 1 Poly(A) polymerase central domain MJ1316 PF04457.12 EXF75149.1 - 2.6e-18 66.5 0.4 5.8e-18 65.4 0.4 1.6 1 0 0 1 1 1 1 MJ1316 RNA cyclic group end recognition domain Exo_endo_phos PF03372.23 EXF75149.1 - 1e-07 31.7 0.1 2.2e-07 30.6 0.1 1.6 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family NTP_transf_2 PF01909.23 EXF75149.1 - 0.00015 22.0 0.0 0.00035 20.8 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyltransferase domain YL1 PF05764.13 EXF75149.1 - 0.012 15.8 1.5 0.019 15.1 1.5 1.2 1 0 0 1 1 1 0 YL1 nuclear protein Cwf_Cwc_15 PF04889.12 EXF75149.1 - 0.92 9.2 6.1 1.7 8.3 6.1 1.4 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Exo70 PF03081.15 EXF75150.1 - 1.9e-90 303.7 0.0 4.4e-90 302.4 0.0 1.6 1 0 0 1 1 1 1 Exo70 exocyst complex subunit RHD3 PF05879.12 EXF75150.1 - 0.047 11.8 0.3 0.088 10.9 0.3 1.3 1 0 0 1 1 1 0 Root hair defective 3 GTP-binding protein (RHD3) Baculo_PEP_C PF04513.12 EXF75150.1 - 0.28 11.2 7.3 22 5.1 1.0 4.1 4 1 1 5 5 5 0 Baculovirus polyhedron envelope protein, PEP, C terminus GAS PF13851.6 EXF75150.1 - 1.2 8.4 11.0 2.9 7.2 0.2 3.6 4 0 0 4 4 4 0 Growth-arrest specific micro-tubule binding DUF2203 PF09969.9 EXF75150.1 - 1.4 9.7 5.9 0.39 11.4 0.2 2.9 4 0 0 4 4 4 0 Uncharacterized conserved protein (DUF2203) Aminotran_3 PF00202.21 EXF75151.1 - 1.7e-83 280.5 0.0 2.1e-83 280.3 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III MCM PF00493.23 EXF75152.1 - 3.8e-97 323.8 0.3 6.7e-97 323.0 0.3 1.4 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EXF75152.1 - 2.1e-31 108.4 0.0 3.8e-31 107.5 0.0 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EXF75152.1 - 1.7e-23 82.9 0.7 3.5e-23 81.8 0.7 1.6 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 EXF75152.1 - 9.6e-11 42.2 0.0 3.4e-10 40.4 0.0 1.9 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 EXF75152.1 - 3.4e-07 29.9 0.0 4.1e-06 26.3 0.0 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 EXF75152.1 - 0.0035 17.2 0.0 0.0088 15.9 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EXF75152.1 - 0.018 14.7 0.0 0.046 13.4 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain Dehydrin PF00257.19 EXF75152.1 - 1.3 9.5 7.0 1 9.9 0.4 3.4 4 0 0 4 4 4 0 Dehydrin PfkB PF00294.24 EXF75153.1 - 7.5e-17 61.6 0.1 1.6e-09 37.5 0.8 2.2 2 0 0 2 2 2 2 pfkB family carbohydrate kinase Pes-10 PF07149.11 EXF75154.1 - 0.13 11.2 0.1 5.7 5.9 0.0 2.1 1 1 1 2 2 2 0 Pes-10 HNF_C PF09354.10 EXF75155.1 - 0.28 12.2 0.9 7.4 7.7 0.2 2.4 1 1 1 2 2 2 0 HNF3 C-terminal domain Rho_Binding PF08912.11 EXF75155.1 - 3.7 8.4 6.0 0.39 11.6 1.7 1.5 2 0 0 2 2 2 0 Rho Binding adh_short_C2 PF13561.6 EXF75156.1 - 1.9e-59 201.1 1.8 2.2e-59 200.9 1.8 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF75156.1 - 7.9e-43 146.2 1.6 1e-42 145.8 1.6 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EXF75156.1 - 2.2e-15 57.0 0.5 3.1e-15 56.6 0.5 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EXF75156.1 - 0.0049 16.4 0.3 0.021 14.3 0.3 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Amidase02_C PF12123.8 EXF75156.1 - 0.027 14.1 0.1 0.11 12.3 0.1 2.0 2 0 0 2 2 2 0 N-acetylmuramoyl-l-alanine amidase GDP_Man_Dehyd PF16363.5 EXF75156.1 - 0.037 13.4 0.1 0.19 11.1 0.0 1.9 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase LDcluster4 PF18306.1 EXF75156.1 - 0.043 13.4 0.1 0.078 12.6 0.1 1.4 1 0 0 1 1 1 0 SLOG cluster4 family DUF134 PF02001.16 EXF75156.1 - 0.088 13.4 0.3 0.19 12.3 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function DUF134 NAD_binding_8 PF13450.6 EXF75157.1 - 1.6e-09 37.8 0.3 4.5e-09 36.4 0.3 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 EXF75157.1 - 3e-09 36.5 1.8 2.6e-07 30.1 0.1 2.2 2 0 0 2 2 2 2 Thi4 family FAD_binding_2 PF00890.24 EXF75157.1 - 8.9e-08 31.6 1.3 5.1e-06 25.8 0.9 2.2 2 0 0 2 2 2 1 FAD binding domain DAO PF01266.24 EXF75157.1 - 1.2e-07 31.6 2.9 2.2e-05 24.2 0.2 2.5 3 0 0 3 3 3 2 FAD dependent oxidoreductase Amino_oxidase PF01593.24 EXF75157.1 - 7.6e-06 25.5 0.4 0.00028 20.3 0.5 2.6 2 1 0 2 2 2 1 Flavin containing amine oxidoreductase FAD_oxidored PF12831.7 EXF75157.1 - 1.1e-05 25.0 0.2 4.7e-05 22.9 0.3 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase GDI PF00996.18 EXF75157.1 - 2e-05 23.3 0.0 0.00037 19.2 0.0 2.1 2 0 0 2 2 2 1 GDP dissociation inhibitor Pyr_redox_2 PF07992.14 EXF75157.1 - 0.00047 19.5 0.0 0.0033 16.7 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EXF75157.1 - 0.00087 18.6 0.1 0.0014 18.0 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain MCRA PF06100.11 EXF75157.1 - 0.0011 17.9 0.1 0.0018 17.2 0.1 1.3 1 0 0 1 1 1 1 MCRA family HI0933_like PF03486.14 EXF75157.1 - 0.0011 17.7 0.7 0.0027 16.5 0.4 1.7 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox PF00070.27 EXF75157.1 - 0.0018 18.8 0.8 0.084 13.4 0.4 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EXF75157.1 - 0.01 15.0 1.1 0.019 14.1 1.1 1.4 1 0 0 1 1 1 0 Glucose inhibited division protein A Trp_halogenase PF04820.14 EXF75157.1 - 0.12 11.2 0.6 0.17 10.7 0.6 1.1 1 0 0 1 1 1 0 Tryptophan halogenase Choline_kin_N PF04428.14 EXF75157.1 - 0.19 11.5 0.0 0.36 10.5 0.0 1.4 1 0 0 1 1 1 0 Choline kinase N terminus Pyr_redox_3 PF13738.6 EXF75157.1 - 0.3 10.3 0.3 1.3 8.2 0.3 1.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Fungal_trans PF04082.18 EXF75158.1 - 6.5e-13 48.3 2.3 1.2e-12 47.5 2.3 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-H2C2_2 PF13465.6 EXF75158.1 - 0.00015 22.1 0.4 0.00015 22.1 0.4 2.0 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2 PF00096.26 EXF75158.1 - 0.0091 16.4 1.5 0.0091 16.4 1.5 3.9 4 0 0 4 4 4 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EXF75158.1 - 0.021 15.6 1.0 0.021 15.6 1.0 3.8 4 0 0 4 4 4 0 C2H2-type zinc finger Peptidase_S15 PF02129.18 EXF75159.1 - 5.7e-37 127.8 3.8 3.4e-31 108.8 0.4 2.4 2 0 0 2 2 2 2 X-Pro dipeptidyl-peptidase (S15 family) PepX_C PF08530.10 EXF75159.1 - 5.8e-32 111.5 0.0 1.8e-31 109.8 0.0 1.8 1 1 0 1 1 1 1 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain EthD PF07110.11 EXF75159.1 - 1.9e-08 35.3 0.5 1e-06 29.8 0.0 2.7 3 0 0 3 3 3 1 EthD domain Peptidase_S9 PF00326.21 EXF75159.1 - 0.0049 16.4 0.3 0.037 13.5 0.3 2.3 1 1 0 1 1 1 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 EXF75159.1 - 0.024 13.9 0.0 1.2 8.4 0.0 2.2 2 0 0 2 2 2 0 Serine aminopeptidase, S33 LRR_4 PF12799.7 EXF75160.1 - 4.2e-11 42.9 17.6 0.00078 19.8 0.4 5.8 5 2 1 6 6 6 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EXF75160.1 - 2.5e-08 33.5 18.7 0.0076 16.0 2.8 5.2 4 1 2 6 6 6 4 Leucine rich repeat LRR_1 PF00560.33 EXF75160.1 - 7.8e-06 25.8 10.6 17 6.4 0.1 8.1 8 0 0 8 8 8 1 Leucine Rich Repeat LRRNT_2 PF08263.12 EXF75160.1 - 0.0004 20.6 0.2 0.00081 19.6 0.2 1.6 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain LRR_6 PF13516.6 EXF75160.1 - 3 8.1 15.0 7.4 6.9 0.0 5.8 7 0 0 7 7 7 0 Leucine Rich repeat Glyco_hydro_2_N PF02837.18 EXF75161.1 - 5.5e-17 62.2 0.0 1.9e-16 60.4 0.0 2.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2_C PF02836.17 EXF75161.1 - 5.9e-09 35.4 0.1 2e-08 33.7 0.0 1.8 2 0 0 2 2 2 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_2 PF00703.21 EXF75161.1 - 7.2e-09 36.3 0.0 1.8e-08 35.0 0.0 1.6 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 BetaGal_dom4_5 PF13364.6 EXF75161.1 - 0.082 13.5 2.5 0.1 13.2 0.5 2.1 2 0 0 2 2 2 0 Beta-galactosidase jelly roll domain Aa_trans PF01490.18 EXF75162.1 - 1.1e-44 152.8 27.0 1.2e-44 152.6 27.0 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 EXF75162.1 - 9e-06 25.0 10.9 9e-06 25.0 10.9 2.1 1 1 1 2 2 2 1 Tryptophan/tyrosine permease family DUF433 PF04255.14 EXF75162.1 - 0.039 13.8 0.1 0.11 12.4 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF433) Spore_permease PF03845.13 EXF75162.1 - 0.42 9.4 13.2 9.7 4.9 13.2 2.5 1 1 0 1 1 1 0 Spore germination protein Bap31 PF05529.12 EXF75162.1 - 1.6 8.6 5.0 0.45 10.4 1.0 2.1 2 0 0 2 2 2 0 Bap31/Bap29 transmembrane region Kelch_5 PF13854.6 EXF75163.1 - 2.3e-15 56.2 6.7 1.7e-06 27.9 0.1 4.8 4 0 0 4 4 4 4 Kelch motif Kelch_6 PF13964.6 EXF75163.1 - 3e-10 40.0 5.6 0.0052 17.0 0.1 5.1 5 0 0 5 5 5 3 Kelch motif Kelch_4 PF13418.6 EXF75163.1 - 6e-10 39.0 4.4 0.17 11.9 0.1 5.9 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_3 PF13415.6 EXF75163.1 - 1.3e-07 31.8 13.7 0.006 16.8 0.0 6.0 6 0 0 6 6 6 2 Galactose oxidase, central domain Kelch_1 PF01344.25 EXF75163.1 - 1.3e-06 27.8 7.5 0.0052 16.3 0.1 5.0 5 0 0 5 5 5 2 Kelch motif Kelch_2 PF07646.15 EXF75163.1 - 0.00017 21.4 2.3 0.067 13.2 0.0 4.2 4 0 0 4 4 4 1 Kelch motif RR_TM4-6 PF06459.12 EXF75163.1 - 0.42 10.4 2.4 0.7 9.7 2.4 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Nop14 PF04147.12 EXF75163.1 - 2.6 6.2 6.8 3.7 5.6 6.8 1.2 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 EXF75163.1 - 4 5.6 6.3 6 5.0 6.3 1.1 1 0 0 1 1 1 0 CDC45-like protein Pyr_redox_2 PF07992.14 EXF75164.1 - 4.5e-14 52.4 0.0 1.5e-08 34.2 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EXF75164.1 - 4.9e-05 22.7 0.0 0.012 14.9 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EXF75164.1 - 0.00014 21.1 0.6 0.097 11.7 0.0 2.3 1 1 1 2 2 2 2 Glucose inhibited division protein A K_oxygenase PF13434.6 EXF75164.1 - 0.00025 20.3 0.0 0.1 11.7 0.0 2.2 2 0 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) HI0933_like PF03486.14 EXF75164.1 - 0.00029 19.7 0.1 0.0021 16.8 0.0 1.9 2 0 0 2 2 2 1 HI0933-like protein NAD_binding_8 PF13450.6 EXF75164.1 - 0.00036 20.7 0.1 0.0009 19.4 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 EXF75164.1 - 0.00078 18.7 0.0 0.012 14.9 0.1 2.1 2 0 0 2 2 2 1 Thi4 family FAD_binding_2 PF00890.24 EXF75164.1 - 0.0012 18.1 3.1 0.0052 15.9 0.1 2.6 2 1 1 3 3 3 1 FAD binding domain NAD_binding_9 PF13454.6 EXF75164.1 - 0.0028 17.6 0.6 1.5 8.8 0.1 2.5 2 0 0 2 2 2 2 FAD-NAD(P)-binding Lycopene_cycl PF05834.12 EXF75164.1 - 0.0041 16.2 0.0 0.17 10.9 0.0 2.1 2 0 0 2 2 2 1 Lycopene cyclase protein DAO PF01266.24 EXF75164.1 - 0.0048 16.5 1.8 0.076 12.6 0.3 2.2 1 1 1 2 2 2 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 EXF75164.1 - 0.0087 15.3 0.0 0.017 14.4 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 EXF75164.1 - 0.032 13.6 0.7 0.047 13.0 0.2 1.5 2 0 0 2 2 2 0 FAD dependent oxidoreductase DIOX_N PF14226.6 EXF75165.1 - 5.8e-15 56.1 0.1 1.4e-14 54.9 0.1 1.6 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EXF75165.1 - 9e-15 55.0 0.0 1.9e-14 54.0 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily OxoDH_E1alpha_N PF12573.8 EXF75165.1 - 0.42 10.4 3.9 2 8.3 0.0 2.9 3 0 0 3 3 3 0 2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal MFS_1 PF07690.16 EXF75166.1 - 4.8e-26 91.5 35.8 4.8e-26 91.5 35.8 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily TrkH PF02386.16 EXF75167.1 - 8.1e-117 390.7 4.9 7.5e-116 387.5 0.3 2.0 2 0 0 2 2 2 2 Cation transport protein CUE PF02845.16 EXF75168.1 - 1.1e-07 31.4 0.0 1.8e-07 30.7 0.0 1.3 1 0 0 1 1 1 1 CUE domain LAP2alpha PF11560.8 EXF75169.1 - 0.17 11.3 0.0 0.3 10.5 0.0 1.3 1 0 0 1 1 1 0 Lamina-associated polypeptide 2 alpha ADH_zinc_N_2 PF13602.6 EXF75170.1 - 1.2e-28 100.8 0.2 2.1e-28 100.0 0.2 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 EXF75170.1 - 1.9e-15 57.0 1.5 4.3e-15 55.8 0.4 2.2 2 1 1 3 3 3 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EXF75170.1 - 1.3e-07 31.5 0.4 2e-05 24.5 0.0 2.9 1 1 2 3 3 3 2 Alcohol dehydrogenase GroES-like domain Transferase PF02458.15 EXF75171.1 - 4.9e-24 84.8 0.0 6.9e-17 61.2 0.0 2.5 2 1 0 2 2 2 2 Transferase family Condensation PF00668.20 EXF75171.1 - 0.22 10.2 0.0 0.33 9.6 0.0 1.1 1 0 0 1 1 1 0 Condensation domain Thionin PF00321.17 EXF75172.1 - 0.41 11.2 0.1 0.41 11.2 0.1 13.3 16 5 0 16 16 16 0 Plant thionin PAN_4 PF14295.6 EXF75173.1 - 0.00023 21.0 6.9 0.00061 19.7 1.0 3.3 2 0 0 2 2 2 1 PAN domain PAN_3 PF08277.12 EXF75173.1 - 0.005 16.6 4.7 0.0058 16.4 0.8 2.6 2 0 0 2 2 2 1 PAN-like domain DUF966 PF06136.13 EXF75173.1 - 2.8 7.6 14.6 4 7.1 14.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF966) TPR_7 PF13176.6 EXF75174.1 - 0.00054 19.8 0.1 0.79 9.9 0.0 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 EXF75174.1 - 0.067 13.7 9.4 0.48 11.0 0.1 3.9 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.6 EXF75174.1 - 0.23 12.4 3.7 60 4.8 0.0 4.6 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_12 PF13424.6 EXF75174.1 - 2.2 8.6 5.0 2 8.8 0.4 3.3 2 1 1 3 3 3 0 Tetratricopeptide repeat NAD_binding_6 PF08030.12 EXF75175.1 - 8.9e-20 71.4 0.0 1.7e-19 70.5 0.0 1.5 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.19 EXF75175.1 - 2.8e-15 56.5 14.4 5.1e-15 55.7 9.4 2.5 1 1 1 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 EXF75175.1 - 1.6e-09 37.8 0.0 1.2e-08 35.0 0.0 2.1 2 0 0 2 2 2 1 FAD-binding domain NAD_binding_1 PF00175.21 EXF75175.1 - 0.00023 21.8 0.0 0.092 13.4 0.0 2.5 1 1 1 2 2 2 2 Oxidoreductase NAD-binding domain MFS_1 PF07690.16 EXF75176.1 - 7.7e-25 87.6 28.9 4.3e-18 65.4 11.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF75176.1 - 2.3e-10 39.9 15.7 6.1e-10 38.6 15.7 1.5 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF75177.1 - 6.4e-41 140.5 26.0 9.1e-41 139.9 26.0 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Fungal_trans PF04082.18 EXF75178.1 - 1.5e-16 60.3 0.0 2.4e-16 59.6 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain FAA_hydrolase PF01557.18 EXF75180.1 - 5.6e-64 215.8 0.0 7.1e-64 215.4 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family DnaJ PF00226.31 EXF75181.1 - 7.3e-05 22.8 0.0 0.018 15.1 0.0 2.5 2 0 0 2 2 2 2 DnaJ domain TSSC4 PF15264.6 EXF75181.1 - 0.021 15.0 1.5 0.044 14.1 1.5 1.5 1 0 0 1 1 1 0 Tumour suppressing sub-chromosomal transferable candidate 4 zf-B_box PF00643.24 EXF75181.1 - 0.033 14.4 5.4 0.064 13.4 5.4 1.5 1 0 0 1 1 1 0 B-box zinc finger Fungal_trans PF04082.18 EXF75182.1 - 1.1e-14 54.2 4.4 1.2e-14 54.0 1.4 2.5 2 1 1 3 3 3 1 Fungal specific transcription factor domain BTB PF00651.31 EXF75183.1 - 6e-06 26.5 0.0 1.6e-05 25.1 0.0 1.8 1 1 0 1 1 1 1 BTB/POZ domain GXWXG PF14231.6 EXF75183.1 - 0.08 13.0 0.0 0.57 10.3 0.0 2.2 2 0 0 2 2 2 0 GXWXG protein CvfB_WH PF17783.1 EXF75183.1 - 0.083 12.7 0.0 0.19 11.6 0.0 1.6 1 0 0 1 1 1 0 CvfB-like winged helix domain YL1 PF05764.13 EXF75183.1 - 0.52 10.4 10.0 0.74 9.9 10.0 1.2 1 0 0 1 1 1 0 YL1 nuclear protein p450 PF00067.22 EXF75184.1 - 8.5e-68 229.2 0.0 1.7e-63 215.0 0.0 2.1 2 0 0 2 2 2 2 Cytochrome P450 Ank PF00023.30 EXF75185.1 - 4.5e-12 45.8 0.5 2e-09 37.5 0.2 3.1 3 0 0 3 3 3 1 Ankyrin repeat Ank_5 PF13857.6 EXF75185.1 - 6.5e-12 45.4 0.1 3.2e-09 36.9 0.1 2.2 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EXF75185.1 - 1.8e-10 41.3 0.0 4.4e-10 40.0 0.0 1.6 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EXF75185.1 - 5.5e-10 38.6 0.0 6.5e-07 29.2 0.0 3.1 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.6 EXF75185.1 - 5.7e-10 39.5 0.3 6.8e-05 23.3 0.1 2.9 1 1 1 2 2 2 2 Ankyrin repeats (many copies) DGCR6 PF07324.11 EXF75187.1 - 0.095 12.3 0.2 5.6 6.5 0.0 2.1 2 0 0 2 2 2 0 DiGeorge syndrome critical region 6 (DGCR6) protein adh_short_C2 PF13561.6 EXF75189.1 - 8.1e-49 166.3 5.5 3.1e-39 134.9 3.7 2.0 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF75189.1 - 1.1e-43 149.0 3.9 1.4e-43 148.7 3.9 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EXF75189.1 - 1.2e-15 57.9 1.4 1.7e-15 57.4 1.4 1.2 1 0 0 1 1 1 1 KR domain 3HCDH_N PF02737.18 EXF75189.1 - 0.0068 16.3 0.8 0.011 15.7 0.8 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain AdoHcyase_NAD PF00670.21 EXF75189.1 - 0.0069 16.5 0.7 0.011 15.8 0.7 1.4 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain THF_DHG_CYH_C PF02882.19 EXF75189.1 - 0.0099 15.2 0.3 0.018 14.4 0.3 1.3 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain 2-Hacid_dh_C PF02826.19 EXF75189.1 - 0.11 11.8 0.2 0.17 11.2 0.2 1.2 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Glycos_transf_2 PF00535.26 EXF75190.1 - 8.8e-36 123.3 0.0 1e-35 123.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 EXF75190.1 - 1.1e-13 51.7 0.0 1.3e-13 51.3 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 EXF75190.1 - 1.3e-05 24.9 0.0 1.7e-05 24.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 EXF75190.1 - 3.7e-05 23.3 0.0 6.2e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 21 DDE_3 PF13358.6 EXF75190.1 - 0.21 11.3 0.0 1.5 8.6 0.0 2.0 1 1 0 1 1 1 0 DDE superfamily endonuclease baeRF_family12 PF18856.1 EXF75191.1 - 0.13 12.9 1.1 0.32 11.6 1.1 1.7 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 12 RPS31 PF17067.5 EXF75191.1 - 0.51 10.5 0.1 0.51 10.5 0.1 2.8 3 0 0 3 3 3 0 Ribosomal protein S31e RSN1_7TM PF02714.15 EXF75192.1 - 1.8e-78 263.6 21.2 1.8e-78 263.6 21.2 1.7 2 0 0 2 2 2 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 EXF75192.1 - 1.3e-40 138.7 1.6 3.1e-40 137.5 1.6 1.7 1 0 0 1 1 1 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 EXF75192.1 - 1.4e-39 136.2 0.1 1.9e-39 135.7 0.1 1.2 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter DUF588 PF04535.12 EXF75192.1 - 0.25 11.1 5.9 0.062 13.1 0.5 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF588) SCIMP PF15050.6 EXF75192.1 - 0.25 11.8 2.2 0.82 10.1 0.7 2.5 2 0 0 2 2 2 0 SCIMP protein AATase PF07247.12 EXF75193.1 - 2.1e-21 76.1 0.0 6.8e-14 51.3 0.0 3.3 2 1 1 3 3 3 3 Alcohol acetyltransferase WES_acyltransf PF03007.16 EXF75193.1 - 0.01 15.6 0.1 0.16 11.7 0.1 2.6 2 1 0 2 2 2 0 Wax ester synthase-like Acyl-CoA acyltransferase domain HAD_2 PF13419.6 EXF75195.1 - 1.2e-18 67.9 0.0 1.7e-18 67.3 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EXF75195.1 - 1.3e-11 45.2 0.6 2.9e-11 44.1 0.6 1.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 EXF75195.1 - 1.2e-07 32.3 0.2 1.8e-07 31.8 0.2 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EXF75195.1 - 0.0035 17.4 0.0 0.0075 16.3 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase_6 PF13344.6 EXF75195.1 - 0.032 14.3 0.0 0.24 11.5 0.0 2.2 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase PTPS_related PF10131.9 EXF75195.1 - 0.084 11.2 0.0 0.085 11.2 0.0 1.1 1 0 0 1 1 1 0 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein 5_nucleotid PF05761.14 EXF75195.1 - 0.13 11.1 0.0 19 4.0 0.0 2.9 3 0 0 3 3 3 0 5' nucleotidase family DUF2226 PF09987.9 EXF75195.1 - 0.14 11.5 0.0 0.19 11.0 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2226) Antimicrobial22 PF16047.5 EXF75195.1 - 4.1 7.4 7.1 3.5 7.6 4.4 2.3 2 0 0 2 2 2 0 Frog antimicrobial peptide GFO_IDH_MocA PF01408.22 EXF75196.1 - 2.8e-16 60.4 0.0 5.5e-16 59.5 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold NAD_binding_3 PF03447.16 EXF75196.1 - 0.00024 21.8 0.1 0.00046 20.8 0.1 1.4 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain GFO_IDH_MocA_C PF02894.17 EXF75196.1 - 0.17 11.9 0.1 0.36 10.8 0.1 1.8 1 1 0 1 1 1 0 Oxidoreductase family, C-terminal alpha/beta domain DUF1768 PF08719.11 EXF75197.1 - 1.3e-57 194.6 0.1 2.5e-57 193.6 0.0 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF1768) Tim44 PF04280.15 EXF75198.1 - 3e-38 131.2 0.0 1.2e-37 129.2 0.0 2.0 2 0 0 2 2 2 1 Tim44-like domain DNA_pol_phi PF04931.13 EXF75198.1 - 0.19 9.8 9.5 0.29 9.2 9.5 1.2 1 0 0 1 1 1 0 DNA polymerase phi PPL5 PF18168.1 EXF75198.1 - 0.62 9.3 8.3 1.2 8.4 8.3 1.4 1 0 0 1 1 1 0 Prim-pol family 5 CDC45 PF02724.14 EXF75198.1 - 6.3 5.0 12.9 11 4.2 12.9 1.3 1 0 0 1 1 1 0 CDC45-like protein Ribosomal_S11 PF00411.19 EXF75199.1 - 2e-09 37.8 0.1 4.7e-09 36.6 0.0 1.6 2 0 0 2 2 2 1 Ribosomal protein S11 Phage_Mu_Gam PF07352.12 EXF75199.1 - 0.066 13.1 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 Bacteriophage Mu Gam like protein Peptidase_C97 PF05903.14 EXF75200.1 - 9.7e-35 119.6 0.0 1.2e-34 119.3 0.0 1.1 1 0 0 1 1 1 1 PPPDE putative peptidase domain LRAT PF04970.13 EXF75200.1 - 0.01 16.1 0.0 0.016 15.5 0.0 1.3 1 0 0 1 1 1 0 Lecithin retinol acyltransferase YchF-GTPase_C PF06071.13 EXF75201.1 - 2.8e-33 113.9 0.4 8.3e-33 112.4 0.1 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.23 EXF75201.1 - 9.6e-16 57.9 0.0 2.4e-15 56.6 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase TPR_19 PF14559.6 EXF75201.1 - 0.00021 21.7 0.2 0.16 12.5 0.0 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat FeoB_N PF02421.18 EXF75201.1 - 0.001 18.6 0.0 0.0021 17.6 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B TGS PF02824.21 EXF75201.1 - 0.0027 17.7 0.0 0.0072 16.4 0.0 1.7 1 0 0 1 1 1 1 TGS domain ANAPC3 PF12895.7 EXF75201.1 - 0.013 15.7 0.0 0.025 14.8 0.0 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_4 PF07721.14 EXF75201.1 - 0.038 14.6 7.8 1.7 9.5 2.4 4.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 EXF75201.1 - 0.29 11.8 1.0 57 4.7 0.0 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 EXF75201.1 - 1.7 9.3 9.5 1.5 9.6 1.4 3.9 3 1 1 4 4 4 0 Tetratricopeptide repeat Peptidase_S8 PF00082.22 EXF75203.1 - 2.9e-23 82.6 0.4 4.8e-23 81.9 0.4 1.3 1 0 0 1 1 1 1 Subtilase family fn3_5 PF06280.12 EXF75203.1 - 1.1e-11 45.4 0.0 2.5e-11 44.3 0.0 1.6 1 0 0 1 1 1 1 Fn3-like domain DUF4074 PF13293.6 EXF75203.1 - 0.18 12.2 0.9 1.3 9.4 0.2 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4074) Ank_2 PF12796.7 EXF75204.1 - 6e-39 132.5 0.8 2.9e-12 47.0 0.0 6.2 2 2 3 6 6 6 6 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EXF75204.1 - 1.3e-27 95.5 1.0 3.7e-05 23.9 0.0 7.2 3 2 3 6 6 6 6 Ankyrin repeats (many copies) Ank PF00023.30 EXF75204.1 - 5.7e-24 83.5 2.8 0.12 12.9 0.0 9.3 9 0 0 9 9 9 7 Ankyrin repeat Ank_4 PF13637.6 EXF75204.1 - 6.9e-23 80.7 0.7 5.7e-06 26.8 0.0 7.8 4 3 5 9 9 9 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EXF75204.1 - 2.1e-20 70.6 0.2 0.067 13.8 0.0 9.5 11 0 0 11 11 11 6 Ankyrin repeat ELYS-bb PF16687.5 EXF75206.1 - 0.042 12.5 0.0 0.068 11.8 0.0 1.3 1 0 0 1 1 1 0 beta-propeller of ELYS nucleoporin WD40 PF00400.32 EXF75206.1 - 0.3 12.0 1.4 38 5.4 0.2 3.9 4 0 0 4 4 4 0 WD domain, G-beta repeat HlyIII PF03006.20 EXF75207.1 - 1.1e-65 221.5 15.5 1.3e-65 221.3 15.5 1.1 1 0 0 1 1 1 1 Haemolysin-III related TssN PF17555.2 EXF75207.1 - 0.025 14.0 0.6 0.025 14.0 0.6 2.3 1 1 0 2 2 2 0 Type VI secretion system, TssN TMA7 PF09072.10 EXF75208.1 - 6.7e-27 94.1 18.8 7.4e-27 94.0 18.8 1.0 1 0 0 1 1 1 1 Translation machinery associated TMA7 Pkinase PF00069.25 EXF75209.1 - 6.5e-29 101.1 0.0 1.1e-28 100.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF75209.1 - 2.6e-13 49.8 0.0 3.6e-13 49.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase p450 PF00067.22 EXF75210.1 - 1e-49 169.5 0.0 1.9e-49 168.7 0.0 1.3 1 1 0 1 1 1 1 Cytochrome P450 Phage_T7_Capsid PF05396.11 EXF75210.1 - 0.065 13.6 0.0 0.21 11.9 0.0 1.8 2 0 0 2 2 2 0 Phage T7 capsid assembly protein CFEM PF05730.11 EXF75211.1 - 0.091 12.9 0.6 0.14 12.3 0.6 1.3 1 0 0 1 1 1 0 CFEM domain PIG-P PF08510.12 EXF75211.1 - 2.5 8.0 6.0 0.35 10.8 1.8 1.8 2 0 0 2 2 2 0 PIG-P Lipase_GDSL_2 PF13472.6 EXF75212.1 - 1e-17 65.1 0.7 1.2e-17 64.9 0.7 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EXF75212.1 - 3.2e-12 46.8 0.2 3.8e-12 46.6 0.2 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_3 PF14606.6 EXF75212.1 - 0.00083 19.5 0.1 0.0015 18.7 0.0 1.4 2 0 0 2 2 2 1 GDSL-like Lipase/Acylhydrolase family Glyco_hydro_3_C PF01915.22 EXF75213.1 - 1.2e-47 162.5 0.0 2e-47 161.8 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 EXF75213.1 - 5.5e-36 124.5 0.0 1.1e-35 123.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 EXF75213.1 - 5.5e-23 80.9 0.1 9.6e-23 80.1 0.1 1.4 1 0 0 1 1 1 1 Fibronectin type III-like domain DUF218 PF02698.17 EXF75214.1 - 3.8e-14 52.8 0.0 5e-14 52.4 0.0 1.1 1 0 0 1 1 1 1 DUF218 domain Rhodanese PF00581.20 EXF75214.1 - 0.014 15.9 0.0 0.7 10.4 0.0 2.0 1 1 1 2 2 2 0 Rhodanese-like domain Peptidase_M20 PF01546.28 EXF75215.1 - 1.3e-10 41.3 0.4 2.3e-10 40.5 0.4 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EXF75215.1 - 2.6e-07 30.5 0.0 1.2e-06 28.4 0.0 2.2 1 1 0 1 1 1 1 Peptidase dimerisation domain Fungal_trans_2 PF11951.8 EXF75216.1 - 2.3e-10 39.8 0.4 9.6e-10 37.8 0.4 1.8 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF75216.1 - 8.2e-09 35.4 9.6 1.4e-08 34.7 9.6 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.16 EXF75217.1 - 1.7e-31 109.4 37.8 1.7e-31 109.4 37.8 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily GtrA PF04138.14 EXF75217.1 - 3.2 8.0 15.6 2.1 8.6 0.0 4.3 3 2 2 5 5 5 0 GtrA-like protein DUF3425 PF11905.8 EXF75218.1 - 1.4e-17 63.8 0.0 3e-17 62.7 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) Glyco_hydro_16 PF00722.21 EXF75219.1 - 4.8e-11 42.5 0.0 7.8e-11 41.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 SKN1 PF03935.15 EXF75219.1 - 0.00082 17.9 0.5 0.058 11.8 1.8 2.1 2 0 0 2 2 2 2 Beta-glucan synthesis-associated protein (SKN1) DHH PF01368.20 EXF75219.1 - 0.026 14.8 0.0 0.043 14.0 0.0 1.4 1 0 0 1 1 1 0 DHH family Mannosyl_trans2 PF04188.13 EXF75221.1 - 6.4e-56 190.5 8.1 7.9e-56 190.2 8.1 1.1 1 0 0 1 1 1 1 Mannosyltransferase (PIG-V) PMT PF02366.18 EXF75221.1 - 0.0024 17.5 5.9 0.0024 17.5 5.9 2.3 2 1 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase Phage_GPD PF05954.11 EXF75221.1 - 0.057 12.7 0.0 0.36 10.1 0.0 2.1 2 0 0 2 2 2 0 Phage late control gene D protein (GPD) SLAC1 PF03595.17 EXF75223.1 - 3e-85 286.3 47.1 3.4e-85 286.2 47.1 1.0 1 0 0 1 1 1 1 Voltage-dependent anion channel MurJ PF03023.14 EXF75223.1 - 4.4e-06 25.6 5.8 2e-05 23.4 0.8 2.5 2 0 0 2 2 2 2 Lipid II flippase MurJ Peptidase_M24 PF00557.24 EXF75224.1 - 4e-58 196.6 0.1 7.9e-58 195.6 0.1 1.5 1 1 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 EXF75224.1 - 1e-19 70.5 0.0 2.3e-19 69.3 0.0 1.5 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain NAD_binding_8 PF13450.6 EXF75224.1 - 0.26 11.5 1.2 12 6.2 0.9 2.8 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Zn_clus PF00172.18 EXF75225.1 - 0.00077 19.5 12.0 0.0014 18.7 12.0 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CHZ PF09649.10 EXF75225.1 - 0.0062 16.0 0.0 0.0062 16.0 0.0 1.9 2 0 0 2 2 2 1 Histone chaperone domain CHZ Cyclin_N PF00134.23 EXF75226.1 - 5.5e-44 149.0 0.2 1.2e-43 147.9 0.2 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 EXF75226.1 - 3.1e-36 124.1 0.1 8.5e-36 122.7 0.0 1.8 2 0 0 2 2 2 1 Cyclin, C-terminal domain TRAP_alpha PF03896.16 EXF75227.1 - 1.3e-10 41.0 0.0 1.9e-10 40.5 0.0 1.2 1 0 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit DUF5067 PF16729.5 EXF75227.1 - 0.034 14.1 0.0 0.065 13.1 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5067) AT_hook PF02178.19 EXF75228.1 - 8.3e-06 25.1 44.2 0.015 15.1 4.1 6.1 5 1 1 6 6 6 4 AT hook motif CDC27 PF09507.10 EXF75228.1 - 1.2 8.4 13.3 1.3 8.4 13.3 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 zf-C2HE PF16278.5 EXF75229.1 - 3.3e-17 62.7 0.1 8.4e-17 61.4 0.1 1.7 1 0 0 1 1 1 1 C2HE / C2H2 / C2HC zinc-binding finger HIT PF01230.23 EXF75229.1 - 7.5e-17 61.9 0.4 1.5e-16 60.9 0.4 1.5 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 EXF75229.1 - 1.2e-15 58.0 8.0 9.7e-15 55.0 8.0 2.0 1 1 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding HA2 PF04408.23 EXF75230.1 - 5.4e-17 62.0 0.2 1.5e-15 57.4 0.0 2.7 2 0 0 2 2 2 1 Helicase associated domain (HA2) Helicase_C PF00271.31 EXF75230.1 - 9.3e-16 58.2 0.0 2.1e-15 57.0 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.16 EXF75230.1 - 8.3e-15 54.9 0.0 1.7e-14 53.9 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.29 EXF75230.1 - 9.1e-11 41.8 0.1 1.9e-10 40.8 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 EXF75230.1 - 0.00022 21.3 0.0 0.00045 20.2 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit RWD PF05773.22 EXF75230.1 - 0.0023 18.2 0.1 0.0047 17.2 0.1 1.6 1 0 0 1 1 1 1 RWD domain ATPase PF06745.13 EXF75230.1 - 0.003 17.0 0.0 0.0093 15.3 0.0 1.8 1 0 0 1 1 1 1 KaiC dsRBD2 PF17842.1 EXF75230.1 - 0.0037 17.5 0.0 0.0092 16.2 0.0 1.6 1 0 0 1 1 1 1 Double-stranded RNA binding domain 2 AAA_29 PF13555.6 EXF75230.1 - 0.0068 16.1 0.0 0.016 14.9 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain UBA PF00627.31 EXF75230.1 - 0.0068 16.3 0.0 5.7 7.0 0.0 2.7 2 0 0 2 2 2 2 UBA/TS-N domain DND1_DSRM PF14709.7 EXF75230.1 - 0.018 15.3 0.2 0.058 13.7 0.2 1.9 1 0 0 1 1 1 0 double strand RNA binding domain from DEAD END PROTEIN 1 AAA_22 PF13401.6 EXF75230.1 - 0.025 14.8 1.4 0.2 11.9 1.4 2.5 1 1 0 1 1 1 0 AAA domain T2SSE PF00437.20 EXF75230.1 - 0.06 12.4 0.0 0.15 11.1 0.0 1.6 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_23 PF13476.6 EXF75230.1 - 0.1 13.1 1.3 0.3 11.6 0.1 2.2 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 EXF75230.1 - 0.11 12.1 0.0 0.24 10.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.18 EXF75230.1 - 0.14 11.5 0.0 0.3 10.4 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family InPase PF18823.1 EXF75230.1 - 0.33 10.6 2.7 0.66 9.7 2.7 1.5 1 0 0 1 1 1 0 Inorganic Pyrophosphatase IHABP4_N PF16174.5 EXF75230.1 - 6.3 7.4 12.6 0.21 12.2 2.1 2.7 2 0 0 2 2 2 0 Intracellular hyaluronan-binding protein 4 N-terminal Bac_rhamnosid6H PF17389.2 EXF75231.1 - 4e-12 46.1 0.0 3.4e-11 43.0 0.0 2.0 2 0 0 2 2 2 1 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain GDE_C PF06202.14 EXF75231.1 - 0.075 11.9 0.0 0.12 11.3 0.0 1.2 1 0 0 1 1 1 0 Amylo-alpha-1,6-glucosidase GMC_oxred_C PF05199.13 EXF75232.1 - 1.7e-08 35.1 0.3 7.7e-08 33.0 0.2 2.2 2 0 0 2 2 2 1 GMC oxidoreductase GMC_oxred_N PF00732.19 EXF75232.1 - 5.1e-06 26.1 0.0 3.2e-05 23.4 0.0 2.1 1 1 0 1 1 1 1 GMC oxidoreductase Abhydrolase_6 PF12697.7 EXF75232.1 - 0.0008 20.1 0.2 1.6 9.3 0.0 2.8 2 1 0 2 2 2 2 Alpha/beta hydrolase family DAO PF01266.24 EXF75232.1 - 0.0056 16.3 0.4 0.19 11.3 0.1 2.9 2 1 1 3 3 3 1 FAD dependent oxidoreductase PGAP1 PF07819.13 EXF75232.1 - 0.0078 16.0 0.0 0.23 11.2 0.0 2.4 2 0 0 2 2 2 1 PGAP1-like protein NAD_binding_8 PF13450.6 EXF75232.1 - 0.016 15.5 0.2 0.052 13.8 0.2 1.9 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EXF75232.1 - 0.023 13.8 0.1 0.039 13.0 0.1 1.3 1 0 0 1 1 1 0 FAD binding domain Pyr_redox_2 PF07992.14 EXF75232.1 - 0.044 13.0 0.1 0.044 13.0 0.1 1.8 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase ELFV_dehydrog PF00208.21 EXF75234.1 - 8.9e-86 287.6 3.9 1.1e-85 287.2 3.9 1.1 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ELFV_dehydrog_N PF02812.18 EXF75234.1 - 8.4e-52 174.5 0.0 1.6e-51 173.6 0.0 1.5 1 0 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain NAD_binding_7 PF13241.6 EXF75234.1 - 0.047 14.1 0.1 0.11 12.9 0.1 1.6 2 0 0 2 2 2 0 Putative NAD(P)-binding DNA_pol_B PF00136.21 EXF75235.1 - 3.8e-149 497.3 3.1 5.4e-149 496.8 3.1 1.2 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 EXF75235.1 - 2e-78 263.9 0.1 5.9e-78 262.3 0.0 1.9 2 0 0 2 2 2 1 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.6 EXF75235.1 - 4.3e-17 62.3 6.9 1.1e-16 61.0 6.9 1.8 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta RNase_H_2 PF13482.6 EXF75235.1 - 0.0053 16.8 0.2 0.055 13.5 0.2 2.5 1 1 0 1 1 1 1 RNase_H superfamily DNA_pol_B_2 PF03175.13 EXF75235.1 - 0.0072 15.2 0.4 0.024 13.5 0.0 2.0 2 0 0 2 2 2 1 DNA polymerase type B, organellar and viral DNA_pol_B_exo2 PF10108.9 EXF75235.1 - 0.02 14.6 0.0 0.041 13.6 0.0 1.4 1 0 0 1 1 1 0 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB C1_1 PF00130.22 EXF75235.1 - 0.094 12.6 9.6 0.05 13.5 0.9 2.7 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) DUF1948 PF09185.10 EXF75235.1 - 0.11 12.4 1.7 0.12 12.2 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1948) Rhomboid PF01694.22 EXF75236.1 - 4.8e-35 120.8 9.5 4.8e-35 120.8 9.5 2.1 3 0 0 3 3 3 1 Rhomboid family SOG2 PF10428.9 EXF75236.1 - 0.29 10.3 6.6 0.37 9.9 6.6 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Asparaginase PF00710.20 EXF75239.1 - 3e-57 193.3 0.0 7.8e-57 191.9 0.0 1.7 1 0 0 1 1 1 1 Asparaginase, N-terminal Asparaginase_C PF17763.1 EXF75239.1 - 1e-25 90.2 0.0 1.9e-25 89.3 0.0 1.5 1 0 0 1 1 1 1 Glutaminase/Asparaginase C-terminal domain Ank_2 PF12796.7 EXF75239.1 - 6.5e-09 36.3 0.9 0.00023 21.7 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EXF75239.1 - 1.3e-05 25.7 0.0 0.0024 18.4 0.0 2.6 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 EXF75239.1 - 4e-05 23.9 0.1 2 9.0 0.0 3.7 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 EXF75239.1 - 0.00098 19.4 0.4 0.023 15.0 0.4 2.6 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EXF75239.1 - 0.036 14.6 0.0 32 5.5 0.0 3.8 3 0 0 3 3 3 0 Ankyrin repeat Pkinase PF00069.25 EXF75240.1 - 1.9e-61 207.8 0.0 3.1e-61 207.0 0.0 1.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF75240.1 - 6.7e-29 100.9 0.0 3.9e-28 98.4 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EXF75240.1 - 0.0051 16.2 0.1 0.017 14.4 0.1 1.9 1 1 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EXF75240.1 - 0.014 14.2 0.0 0.022 13.5 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Haspin_kinase PF12330.8 EXF75240.1 - 0.027 13.4 0.3 0.16 10.9 0.3 1.8 1 1 0 1 1 1 0 Haspin like kinase domain UPF0542 PF15086.6 EXF75241.1 - 0.044 13.7 1.4 0.078 12.9 1.4 1.4 1 0 0 1 1 1 0 Uncharacterised protein family UPF0542 AMPK1_CBM PF16561.5 EXF75242.1 - 3.3e-25 88.1 0.0 5.8e-25 87.3 0.0 1.4 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase AMPKBI PF04739.15 EXF75242.1 - 9.2e-25 86.7 1.9 9.2e-25 86.7 1.9 2.5 2 0 0 2 2 2 1 5'-AMP-activated protein kinase beta subunit, interaction domain Peptidase_M22 PF00814.25 EXF75243.1 - 9.6e-84 281.3 0.0 1.2e-83 281.0 0.0 1.1 1 0 0 1 1 1 1 Glycoprotease family Carbam_trans_N PF02543.15 EXF75243.1 - 0.095 12.3 0.0 0.8 9.3 0.0 2.0 2 0 0 2 2 2 0 Carbamoyltransferase N-terminus EPL1 PF10513.9 EXF75244.1 - 1.3e-19 71.1 2.8 1.3e-19 71.1 2.8 2.8 2 1 0 2 2 2 1 Enhancer of polycomb-like EF-hand_1 PF00036.32 EXF75245.1 - 9e-27 90.6 13.2 2.4e-07 29.8 0.8 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 EXF75245.1 - 2.3e-23 82.4 13.9 3.1e-14 53.2 1.4 2.7 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 EXF75245.1 - 1.5e-20 71.3 6.6 4.6e-05 23.0 0.1 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 EXF75245.1 - 7.1e-18 63.2 11.0 1.7e-06 27.2 0.4 4.3 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 EXF75245.1 - 8.3e-13 48.0 12.6 0.00013 21.7 0.5 4.2 2 1 2 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EXF75245.1 - 6e-07 29.8 0.1 0.0014 18.9 0.1 2.3 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 EXF75245.1 - 4.8e-06 26.5 8.2 0.0024 17.8 0.5 3.8 1 1 3 4 4 4 2 Cytoskeletal-regulatory complex EF hand Dockerin_1 PF00404.18 EXF75245.1 - 0.029 14.6 0.8 0.12 12.6 0.7 2.2 1 1 0 1 1 1 0 Dockerin type I domain EF-hand_9 PF14658.6 EXF75245.1 - 0.092 13.1 0.2 4.4 7.7 0.1 3.1 2 1 1 3 3 3 0 EF-hand domain 40S_SA_C PF16122.5 EXF75246.1 - 3.1 9.2 8.5 1.8 10.0 1.6 2.5 1 1 0 2 2 2 0 40S ribosomal protein SA C-terminus Ribosomal_S9 PF00380.19 EXF75249.1 - 6.7e-41 139.6 0.3 1.1e-40 138.9 0.3 1.4 1 0 0 1 1 1 1 Ribosomal protein S9/S16 LnmK_N_HDF PF18238.1 EXF75249.1 - 0.1 12.4 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 LnmK N-terminal Hot Dog Fold domain EF-hand_9 PF14658.6 EXF75249.1 - 0.12 12.7 0.0 0.37 11.2 0.0 1.8 2 0 0 2 2 2 0 EF-hand domain EF1G PF00647.19 EXF75250.1 - 2.9e-44 149.5 0.6 5e-44 148.7 0.6 1.4 1 0 0 1 1 1 1 Elongation factor 1 gamma, conserved domain GST_C PF00043.25 EXF75250.1 - 7.8e-14 51.7 0.0 1.8e-13 50.5 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EXF75250.1 - 3.9e-11 43.1 0.0 9.1e-11 42.0 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EXF75250.1 - 1.3e-08 34.7 0.3 4.4e-08 33.0 0.0 2.1 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EXF75250.1 - 0.00046 20.3 0.0 0.0012 18.9 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EXF75250.1 - 0.00054 20.3 0.0 0.0011 19.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain DEC-1_N PF04625.13 EXF75250.1 - 0.018 14.0 2.3 0.028 13.5 2.3 1.2 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region NIF PF03031.18 EXF75251.1 - 8.4e-20 71.1 0.0 1.5e-19 70.3 0.0 1.4 1 1 0 1 1 1 1 NLI interacting factor-like phosphatase RRP36 PF06102.12 EXF75252.1 - 7.2e-57 192.0 32.5 7.2e-57 192.0 32.5 1.6 2 0 0 2 2 2 1 rRNA biogenesis protein RRP36 Sec16 PF12932.7 EXF75252.1 - 0.35 11.5 2.6 0.32 11.6 0.7 1.8 1 1 1 2 2 2 0 Vesicle coat trafficking protein Sec16 mid-region ABC1 PF03109.16 EXF75253.1 - 1.5e-32 112.2 0.0 2.8e-32 111.4 0.0 1.4 1 0 0 1 1 1 1 ABC1 family Pkinase PF00069.25 EXF75253.1 - 0.081 12.3 0.0 1.3 8.4 0.0 2.1 2 0 0 2 2 2 0 Protein kinase domain Es2 PF09751.9 EXF75254.1 - 3.2e-121 406.1 3.9 3.9e-121 405.8 3.9 1.1 1 0 0 1 1 1 1 Nuclear protein Es2 PPP5 PF08321.12 EXF75255.1 - 9.9e-34 115.5 0.3 9.8e-33 112.3 0.0 2.2 2 0 0 2 2 2 1 PPP5 TPR repeat region Metallophos PF00149.28 EXF75255.1 - 4.1e-31 109.1 0.0 5.8e-31 108.6 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase TPR_1 PF00515.28 EXF75255.1 - 8e-18 63.4 0.8 8.5e-05 22.2 0.0 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 EXF75255.1 - 9.3e-13 47.2 0.3 0.016 15.3 0.0 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 EXF75255.1 - 7.2e-12 44.8 0.5 0.0014 18.2 0.1 3.3 2 1 1 3 3 3 3 TPR repeat TPR_17 PF13431.6 EXF75255.1 - 1.9e-07 31.0 1.9 0.067 13.6 0.0 3.8 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 EXF75255.1 - 5.4e-05 23.1 0.6 2.5 8.5 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 EXF75255.1 - 8.4e-05 22.6 0.0 0.11 12.6 0.0 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 EXF75255.1 - 0.0059 17.1 0.0 13 6.4 0.0 3.1 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 EXF75255.1 - 0.016 15.9 0.0 28 5.9 0.0 3.6 2 1 1 3 3 3 0 Tetratricopeptide repeat Spt4 PF06093.13 EXF75257.1 - 7.7e-33 112.4 0.3 9.5e-33 112.2 0.3 1.1 1 0 0 1 1 1 1 Spt4/RpoE2 zinc finger Coronavirus_5 PF05528.11 EXF75257.1 - 0.032 14.2 0.3 0.12 12.3 0.1 1.9 1 1 1 2 2 2 0 Coronavirus gene 5 protein Kin17_mid PF10357.9 EXF75258.1 - 5.9e-51 171.6 1.8 5.9e-51 171.6 1.8 1.9 2 0 0 2 2 2 1 Domain of Kin17 curved DNA-binding protein zf-met PF12874.7 EXF75258.1 - 2.5e-05 24.5 3.4 5e-05 23.5 3.4 1.5 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EXF75258.1 - 2.6e-05 24.4 2.2 6e-05 23.2 2.2 1.7 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 EXF75258.1 - 0.013 15.9 0.8 0.013 15.9 0.8 2.2 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) NOD PF06816.13 EXF75258.1 - 0.019 14.6 0.0 0.04 13.5 0.0 1.5 1 0 0 1 1 1 0 NOTCH protein AA_kinase PF00696.28 EXF75259.1 - 1.3e-37 129.7 0.0 2.9e-37 128.5 0.0 1.6 1 0 0 1 1 1 1 Amino acid kinase family ACT_7 PF13840.6 EXF75259.1 - 1.4e-13 50.4 4.0 2.7e-09 36.7 0.2 2.5 2 0 0 2 2 2 2 ACT domain ACT PF01842.25 EXF75259.1 - 2.8e-13 49.4 1.3 1.6e-07 31.0 0.1 2.6 2 0 0 2 2 2 2 ACT domain RFX_DNA_binding PF02257.15 EXF75260.1 - 1.9e-27 95.6 0.1 4.5e-27 94.5 0.1 1.6 1 0 0 1 1 1 1 RFX DNA-binding domain TB2_DP1_HVA22 PF03134.19 EXF75261.1 - 2.5e-28 97.8 9.0 4.1e-28 97.1 9.0 1.4 1 0 0 1 1 1 1 TB2/DP1, HVA22 family Mid1 PF12929.7 EXF75262.1 - 7.7e-155 516.3 4.8 9e-155 516.0 4.8 1.0 1 0 0 1 1 1 1 Stretch-activated Ca2+-permeable channel component Fz PF01392.22 EXF75262.1 - 0.0008 20.0 8.2 0.009 16.6 4.0 2.5 2 0 0 2 2 2 2 Fz domain RAMP4 PF06624.12 EXF75264.1 - 4.7e-22 77.8 0.1 5.3e-22 77.7 0.1 1.0 1 0 0 1 1 1 1 Ribosome associated membrane protein RAMP4 SMAP PF15477.6 EXF75265.1 - 8.5e-11 42.7 4.6 8.5e-11 42.7 4.6 5.8 2 1 1 3 3 3 1 Small acidic protein family Methyltransf_25 PF13649.6 EXF75266.1 - 3.4e-14 53.3 0.0 1.3e-13 51.4 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EXF75266.1 - 9.8e-14 51.5 0.0 6.2e-13 48.9 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF75266.1 - 1.2e-11 45.1 0.0 2.6e-11 44.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF75266.1 - 4.8e-07 30.4 0.0 1.3e-06 29.1 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF75266.1 - 3e-06 27.1 0.0 1.1e-05 25.3 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_29 PF03141.16 EXF75266.1 - 0.003 16.2 0.0 0.0045 15.6 0.0 1.2 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Ubie_methyltran PF01209.18 EXF75266.1 - 0.0043 16.4 0.0 0.015 14.6 0.0 1.9 1 1 1 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.17 EXF75266.1 - 0.022 14.2 0.0 0.053 13.0 0.0 1.6 1 0 0 1 1 1 0 Putative methyltransferase YqeY PF09424.10 EXF75267.1 - 1.7e-24 86.5 8.2 2.2e-24 86.2 8.2 1.1 1 0 0 1 1 1 1 Yqey-like protein DUF2017 PF09438.10 EXF75267.1 - 0.0045 16.9 4.8 0.0045 16.9 4.8 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF2017) GCP_N_terminal PF17681.1 EXF75268.1 - 2.1e-63 214.8 0.0 3.7e-63 214.0 0.0 1.4 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 EXF75268.1 - 4e-61 207.2 0.1 4e-61 207.2 0.1 1.6 2 0 0 2 2 2 1 Gamma tubulin complex component C-terminal Proteasome PF00227.26 EXF75269.1 - 1.3e-56 191.1 0.1 1.7e-56 190.7 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EXF75269.1 - 4.4e-11 42.2 0.0 9.2e-11 41.2 0.0 1.6 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Fungal_trans_2 PF11951.8 EXF75270.1 - 1.3e-17 63.8 0.9 5.2e-11 42.0 0.1 3.1 3 0 0 3 3 3 3 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF75270.1 - 3.5e-08 33.4 11.5 6e-08 32.7 11.5 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Methyltransf_8 PF05148.15 EXF75271.1 - 6.6e-58 196.1 0.0 1.3e-56 191.9 0.0 2.7 3 0 0 3 3 3 1 Hypothetical methyltransferase Methyltransf_11 PF08241.12 EXF75271.1 - 5e-05 23.9 0.0 0.0002 21.9 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF75271.1 - 0.00088 19.9 0.0 0.048 14.4 0.0 2.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF75271.1 - 0.0097 15.7 0.0 2.7 7.8 0.0 2.4 2 0 0 2 2 2 2 Methyltransferase domain MTS PF05175.14 EXF75271.1 - 0.035 13.6 0.5 2.9 7.4 0.0 2.6 3 0 0 3 3 3 0 Methyltransferase small domain Methyltransf_32 PF13679.6 EXF75271.1 - 0.071 13.1 0.0 0.071 13.1 0.0 3.2 2 1 0 2 2 2 0 Methyltransferase domain Asp_protease PF09668.10 EXF75272.1 - 1.4e-59 199.3 0.4 2.2e-59 198.7 0.4 1.3 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 EXF75272.1 - 4e-24 85.0 0.1 8.6e-24 83.9 0.1 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 EXF75272.1 - 1e-11 45.3 0.1 2e-11 44.4 0.1 1.5 1 0 0 1 1 1 1 Aspartyl protease UBA PF00627.31 EXF75272.1 - 6.8e-10 38.7 0.1 1.9e-09 37.2 0.1 1.8 1 0 0 1 1 1 1 UBA/TS-N domain ubiquitin PF00240.23 EXF75272.1 - 1.2e-09 37.8 0.1 2.6e-09 36.7 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin family RVP PF00077.20 EXF75272.1 - 0.00011 22.5 0.0 0.00028 21.1 0.0 1.7 1 0 0 1 1 1 1 Retroviral aspartyl protease RVP_2 PF08284.11 EXF75272.1 - 0.00019 21.2 0.0 0.00034 20.4 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease Rad60-SLD PF11976.8 EXF75272.1 - 0.0034 17.2 0.4 0.007 16.2 0.1 1.7 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like CUE PF02845.16 EXF75272.1 - 0.026 14.2 0.0 1.2 8.9 0.0 3.0 4 0 0 4 4 4 0 CUE domain Acetyltransf_10 PF13673.7 EXF75273.1 - 9e-09 35.3 0.0 1.6e-08 34.5 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EXF75273.1 - 2.9e-08 33.9 0.0 4.6e-08 33.3 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EXF75273.1 - 3.3e-07 30.6 0.0 6.1e-07 29.8 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EXF75273.1 - 0.14 12.3 0.0 0.33 11.1 0.0 1.6 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Pribosyltran PF00156.27 EXF75274.1 - 9.4e-16 57.7 0.4 1.5e-15 57.0 0.4 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 EXF75274.1 - 0.11 11.9 0.0 0.18 11.3 0.0 1.2 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase NOG1_N PF17835.1 EXF75275.1 - 3e-49 167.1 0.0 7.9e-49 165.7 0.0 1.8 1 0 0 1 1 1 1 NOG1 N-terminal helical domain NOGCT PF08155.11 EXF75275.1 - 4.8e-28 96.9 1.5 1.1e-27 95.7 1.5 1.7 1 0 0 1 1 1 1 NOGCT (NUC087) domain NOG1 PF06858.14 EXF75275.1 - 4.2e-26 90.5 0.7 9.7e-26 89.3 0.7 1.7 1 0 0 1 1 1 1 Nucleolar GTP-binding protein 1 (NOG1) MMR_HSR1 PF01926.23 EXF75275.1 - 6.4e-15 55.2 0.0 1.5e-14 54.1 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EXF75275.1 - 2.8e-08 33.5 0.0 5.2e-08 32.6 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B Gtr1_RagA PF04670.12 EXF75275.1 - 0.0046 16.4 0.1 0.0076 15.6 0.1 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 EXF75275.1 - 0.0079 16.1 0.6 0.29 11.0 0.1 3.0 2 1 0 2 2 2 1 RsgA GTPase AAA_16 PF13191.6 EXF75275.1 - 0.027 14.9 0.1 0.19 12.1 0.1 2.6 1 1 0 1 1 1 0 AAA ATPase domain MMR_HSR1_Xtn PF16897.5 EXF75275.1 - 0.034 14.2 0.0 0.095 12.7 0.0 1.8 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain Dynamin_N PF00350.23 EXF75275.1 - 2.1 8.4 8.2 2 8.5 0.0 3.2 4 0 0 4 4 4 0 Dynamin family GDI PF00996.18 EXF75276.1 - 5.7e-195 647.9 0.0 6.4e-195 647.7 0.0 1.0 1 0 0 1 1 1 1 GDP dissociation inhibitor NAD_binding_8 PF13450.6 EXF75276.1 - 0.008 16.4 0.0 0.019 15.2 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 EXF75276.1 - 0.11 13.1 0.3 0.96 10.1 0.1 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase MRP-L47 PF06984.13 EXF75277.1 - 6.8e-24 83.8 0.5 1.3e-23 82.9 0.5 1.5 1 0 0 1 1 1 1 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) G-gamma PF00631.22 EXF75278.1 - 4.6e-25 87.4 0.0 8.5e-25 86.6 0.0 1.5 1 0 0 1 1 1 1 GGL domain Dicty_REP PF05086.12 EXF75278.1 - 0.068 11.2 4.8 0.084 10.8 4.8 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein PCI PF01399.27 EXF75280.1 - 2.8e-08 34.2 0.5 1.6e-07 31.8 0.0 2.5 2 0 0 2 2 2 1 PCI domain STAS PF01740.21 EXF75280.1 - 0.038 13.6 0.1 0.095 12.3 0.1 1.6 1 0 0 1 1 1 0 STAS domain WSC PF01822.19 EXF75282.1 - 5.9e-34 116.1 34.7 2.7e-18 65.9 13.1 5.4 5 1 1 6 6 6 2 WSC domain Stm1_N PF09598.10 EXF75283.1 - 7e-14 52.4 2.9 7e-14 52.4 2.9 4.0 4 1 0 4 4 4 1 Stm1 HABP4_PAI-RBP1 PF04774.15 EXF75283.1 - 7.1 7.5 20.9 6.4 7.7 18.0 2.6 1 1 1 2 2 2 0 Hyaluronan / mRNA binding family MFS_1 PF07690.16 EXF75285.1 - 2.9e-21 75.8 33.1 3.3e-11 42.7 7.7 3.1 3 0 0 3 3 3 3 Major Facilitator Superfamily ATG22 PF11700.8 EXF75285.1 - 4.8e-08 32.1 1.1 1.1e-06 27.6 0.0 3.0 3 1 1 4 4 4 2 Vacuole effluxer Atg22 like DUF4022 PF13214.6 EXF75285.1 - 0.014 15.6 2.4 0.073 13.3 0.0 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4022) LacY_symp PF01306.19 EXF75285.1 - 3.3 6.4 12.0 0.1 11.4 5.1 2.0 2 0 0 2 2 2 0 LacY proton/sugar symporter Actin PF00022.19 EXF75286.1 - 5.4e-28 97.7 0.0 1.4e-18 66.7 0.0 2.6 2 1 0 2 2 2 2 Actin Actin_micro PF17003.5 EXF75286.1 - 0.0004 19.7 0.6 0.22 10.6 0.3 2.2 2 0 0 2 2 2 2 Putative actin-like family FtsA PF14450.6 EXF75286.1 - 0.026 14.9 0.0 0.072 13.5 0.0 1.9 1 1 0 1 1 1 0 Cell division protein FtsA MreB_Mbl PF06723.13 EXF75286.1 - 0.072 11.9 0.0 0.2 10.4 0.0 1.6 2 0 0 2 2 2 0 MreB/Mbl protein DUF4451 PF14616.6 EXF75289.1 - 1.3e-23 83.5 0.1 1.3e-23 83.5 0.1 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4451) LRR_8 PF13855.6 EXF75290.1 - 0.013 15.3 0.1 5.8 6.8 0.0 2.9 3 0 0 3 3 3 0 Leucine rich repeat DUF2961 PF11175.8 EXF75291.1 - 9.3e-76 254.6 2.7 1.5e-68 231.0 2.7 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF2961) AIM24 PF01987.17 EXF75293.1 - 0.054 13.3 0.0 0.77 9.5 0.0 2.1 1 1 1 2 2 2 0 Mitochondrial biogenesis AIM24 Aldo_ket_red PF00248.21 EXF75294.1 - 6.4e-60 202.8 0.0 7.8e-60 202.6 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family HET PF06985.11 EXF75295.1 - 1.5e-26 93.5 0.0 2.6e-26 92.7 0.0 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Ank_4 PF13637.6 EXF75296.1 - 2e-08 34.6 0.0 3.3e-06 27.5 0.0 2.6 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EXF75296.1 - 7.4e-08 32.9 0.0 1e-06 29.2 0.0 2.2 1 1 1 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EXF75296.1 - 3.2e-07 30.1 0.1 0.0068 16.8 0.0 4.0 4 1 0 4 4 4 2 Ankyrin repeat Ank PF00023.30 EXF75296.1 - 2.6e-06 27.6 0.0 0.39 11.3 0.0 3.6 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 EXF75296.1 - 2.7e-05 24.4 0.0 0.66 10.4 0.0 3.2 2 1 0 2 2 2 2 Ankyrin repeats (many copies) TFIIS_C PF01096.18 EXF75297.1 - 2.5e-21 75.2 2.4 2.5e-21 75.2 2.4 2.7 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.16 EXF75297.1 - 4.5e-07 29.6 2.0 3.8e-06 26.7 0.2 2.4 2 0 0 2 2 2 1 RNA polymerases M/15 Kd subunit Zn_Tnp_IS1595 PF12760.7 EXF75297.1 - 0.00095 19.1 5.8 0.037 14.0 0.6 2.4 2 1 0 2 2 2 2 Transposase zinc-ribbon domain IBR PF01485.21 EXF75297.1 - 0.012 15.9 6.4 1 9.6 0.2 2.4 2 1 0 2 2 2 0 IBR domain, a half RING-finger domain Desulfoferrod_N PF06397.12 EXF75297.1 - 0.019 14.6 0.6 0.18 11.5 0.1 2.3 2 0 0 2 2 2 0 Desulfoferrodoxin, N-terminal domain zf-3CxxC_2 PF17180.4 EXF75297.1 - 0.15 12.8 4.3 5.3 7.8 0.1 2.3 2 1 0 2 2 2 0 Zinc-binding domain zinc_ribbon_4 PF13717.6 EXF75297.1 - 3.6 7.6 8.9 23 5.0 0.2 3.7 4 0 0 4 4 4 0 zinc-ribbon domain Med31 PF05669.12 EXF75298.1 - 3.3e-31 107.1 0.5 3.3e-31 107.1 0.5 1.7 2 0 0 2 2 2 1 SOH1 SIP1 PF04938.12 EXF75299.1 - 8.5e-07 28.9 0.1 0.00067 19.4 0.0 3.4 3 1 0 3 3 3 2 Survival motor neuron (SMN) interacting protein 1 (SIP1) RNR_inhib PF08591.10 EXF75300.1 - 4.9e-35 121.1 0.1 8.3e-35 120.3 0.1 1.4 1 0 0 1 1 1 1 Ribonucleotide reductase inhibitor Ribosomal_S27e PF01667.17 EXF75301.1 - 4.5e-28 96.7 7.5 6.1e-28 96.3 7.5 1.2 1 0 0 1 1 1 1 Ribosomal protein S27 TF_Zn_Ribbon PF08271.12 EXF75301.1 - 0.2 11.2 3.7 0.3 10.6 3.7 1.2 1 0 0 1 1 1 0 TFIIB zinc-binding zf-C2HC5 PF06221.13 EXF75301.1 - 1.1 9.3 7.1 3.8 7.6 4.4 2.3 2 1 0 2 2 2 0 Putative zinc finger motif, C2HC5-type Phosducin PF02114.16 EXF75302.1 - 2.6e-14 52.8 0.2 3.9e-14 52.2 0.2 1.2 1 0 0 1 1 1 1 Phosducin Thioredoxin PF00085.20 EXF75302.1 - 0.0066 16.4 0.0 0.011 15.7 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin NPH-II PF12011.8 EXF75302.1 - 0.04 13.8 0.0 0.058 13.3 0.0 1.2 1 0 0 1 1 1 0 RNA helicase NPH-II LRR_8 PF13855.6 EXF75303.1 - 6.1e-08 32.3 4.9 5.4e-06 26.1 2.4 3.2 2 1 1 3 3 3 2 Leucine rich repeat LRR_4 PF12799.7 EXF75303.1 - 1e-06 29.0 1.5 1.9e-05 24.9 0.1 3.4 3 1 1 4 4 4 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EXF75303.1 - 0.0053 17.1 2.2 14 6.7 0.0 4.6 4 0 0 4 4 4 1 Leucine Rich Repeat LRR_6 PF13516.6 EXF75303.1 - 0.36 11.0 1.1 48 4.4 0.1 3.1 2 0 0 2 2 2 0 Leucine Rich repeat RTC PF01137.21 EXF75304.1 - 4.3e-49 166.7 0.0 1.1e-48 165.4 0.0 1.7 1 1 0 1 1 1 1 RNA 3'-terminal phosphate cyclase AhpC-TSA PF00578.21 EXF75306.1 - 2e-37 127.9 0.0 2.6e-37 127.5 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EXF75306.1 - 7.5e-12 45.2 0.0 1.1e-11 44.7 0.0 1.1 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 EXF75306.1 - 2.2e-11 43.4 0.0 4.2e-11 42.5 0.0 1.5 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin MMtag PF10159.9 EXF75307.1 - 0.072 13.4 4.6 0.077 13.3 0.2 2.2 2 0 0 2 2 2 0 Multiple myeloma tumor-associated SNARE PF05739.19 EXF75307.1 - 0.86 9.7 2.2 0.59 10.2 0.3 1.6 2 0 0 2 2 2 0 SNARE domain Aspzincin_M35 PF14521.6 EXF75309.1 - 0.0084 16.7 1.0 0.22 12.1 0.1 2.7 2 1 0 2 2 2 1 Lysine-specific metallo-endopeptidase adh_short PF00106.25 EXF75310.1 - 1.9e-13 50.3 0.0 2.5e-13 49.9 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF75310.1 - 3.6e-09 36.5 0.0 4.5e-09 36.2 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.6 EXF75310.1 - 3.5e-07 30.3 0.7 5.6e-07 29.6 0.7 1.3 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EXF75310.1 - 3.9e-06 26.6 1.0 6.4e-06 25.9 1.0 1.3 1 0 0 1 1 1 1 NmrA-like family KR PF08659.10 EXF75310.1 - 0.00036 20.5 0.0 0.00044 20.2 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EXF75310.1 - 0.006 16.1 0.0 0.0092 15.5 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family F420_oxidored PF03807.17 EXF75310.1 - 0.027 15.0 0.1 0.073 13.7 0.0 1.7 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent DUF4465 PF14717.6 EXF75310.1 - 0.065 13.6 0.0 0.1 13.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4465) PALP PF00291.25 EXF75310.1 - 0.08 12.3 0.0 0.11 11.9 0.0 1.2 1 0 0 1 1 1 0 Pyridoxal-phosphate dependent enzyme MFS_1 PF07690.16 EXF75311.1 - 2.4e-25 89.2 18.9 2.4e-25 89.2 18.9 1.7 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF75311.1 - 7.1e-09 35.0 0.2 7.1e-09 35.0 0.2 3.2 3 1 0 3 3 3 2 Sugar (and other) transporter DUF2263 PF10021.9 EXF75312.1 - 1.8e-19 70.6 0.0 4.4e-19 69.3 0.0 1.6 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2263) Macro PF01661.21 EXF75312.1 - 0.005 16.9 0.1 0.065 13.3 0.0 2.3 2 0 0 2 2 2 1 Macro domain DASH_Spc19 PF08287.11 EXF75312.1 - 0.15 12.0 2.6 0.39 10.6 2.6 1.7 1 1 0 1 1 1 0 Spc19 FlaC_arch PF05377.11 EXF75312.1 - 0.17 12.3 1.4 0.35 11.3 1.4 1.4 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) DUF735 PF05246.11 EXF75312.1 - 0.19 11.7 0.0 0.33 10.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF735) EcKinase PF02958.20 EXF75313.1 - 9.3e-13 48.1 0.0 1.7e-12 47.3 0.0 1.3 1 0 0 1 1 1 1 Ecdysteroid kinase APH PF01636.23 EXF75313.1 - 4.8e-07 29.9 0.3 2e-06 27.9 0.0 2.0 2 1 0 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EXF75313.1 - 0.00065 19.3 0.0 0.0011 18.6 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase Hydrophobin PF01185.18 EXF75315.1 - 1.3e-10 41.8 10.6 1.7e-10 41.3 10.6 1.2 1 0 0 1 1 1 1 Fungal hydrophobin Transferase PF02458.15 EXF75316.1 - 9.5e-09 34.4 0.0 4.9e-08 32.0 0.0 2.1 2 1 0 2 2 2 1 Transferase family DUF3433 PF11915.8 EXF75318.1 - 2.3e-26 92.1 16.6 2.8e-20 72.6 2.0 4.0 5 0 0 5 5 5 2 Protein of unknown function (DUF3433) Abhydrolase_3 PF07859.13 EXF75319.1 - 4e-11 43.2 0.8 2.2e-09 37.5 0.8 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EXF75319.1 - 5.3e-08 32.6 0.0 5.8e-07 29.2 0.0 2.0 1 1 0 1 1 1 1 Prolyl oligopeptidase family DLH PF01738.18 EXF75319.1 - 5.2e-07 29.4 0.0 0.00011 21.8 0.0 2.9 3 0 0 3 3 3 1 Dienelactone hydrolase family Hydrolase_4 PF12146.8 EXF75319.1 - 1.3e-06 27.9 0.0 0.002 17.5 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EXF75319.1 - 1e-05 25.3 0.1 0.017 14.8 0.0 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold Esterase_phd PF10503.9 EXF75319.1 - 0.014 14.9 0.3 0.14 11.7 0.3 2.0 1 1 0 1 1 1 0 Esterase PHB depolymerase LIP PF03583.14 EXF75319.1 - 0.02 14.3 0.1 0.21 10.9 0.0 2.0 2 0 0 2 2 2 0 Secretory lipase DUF829 PF05705.14 EXF75319.1 - 0.079 12.8 0.0 0.11 12.3 0.0 1.1 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF829) Glyco_trans_4_4 PF13579.6 EXF75319.1 - 0.15 12.4 2.5 8.3 6.8 0.1 2.2 2 0 0 2 2 2 0 Glycosyl transferase 4-like domain Abhydrolase_2 PF02230.16 EXF75319.1 - 0.25 11.1 0.0 0.74 9.6 0.0 1.6 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase DUF2048 PF09752.9 EXF75319.1 - 0.25 10.4 0.0 0.37 9.8 0.0 1.1 1 0 0 1 1 1 0 Abhydrolase domain containing 18 Fungal_trans PF04082.18 EXF75320.1 - 5.9e-16 58.3 0.2 1.1e-15 57.4 0.2 1.5 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF75320.1 - 1.1e-06 28.6 14.4 1.8e-06 27.9 14.4 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain p450 PF00067.22 EXF75321.1 - 1.8e-69 234.7 0.0 2e-69 234.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 HSP70 PF00012.20 EXF75322.1 - 2.1e-57 194.7 0.0 3.2e-30 104.9 0.0 2.2 2 0 0 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.13 EXF75322.1 - 2e-06 26.9 0.0 2.9e-06 26.3 0.0 1.2 1 0 0 1 1 1 1 MreB/Mbl protein Atg29_N PF18388.1 EXF75323.1 - 3.7e-26 90.7 0.5 6.1e-26 90.0 0.5 1.4 1 0 0 1 1 1 1 Atg29 N-terminal domain Phage_holin_2_4 PF16082.5 EXF75324.1 - 0.093 12.5 0.4 0.18 11.6 0.0 1.7 2 0 0 2 2 2 0 Bacteriophage holin family, superfamily II-like FAM176 PF14851.6 EXF75324.1 - 0.42 10.3 2.9 1.1 8.9 2.9 1.7 1 1 0 1 1 1 0 FAM176 family p450 PF00067.22 EXF75325.1 - 3.7e-64 217.2 0.0 4.7e-64 216.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Glyco_hydro_76 PF03663.14 EXF75326.1 - 8.2e-154 512.5 17.9 9.8e-154 512.3 17.9 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Synaptobrevin PF00957.21 EXF75327.1 - 3.7e-33 113.2 1.0 4.2e-33 113.0 1.0 1.1 1 0 0 1 1 1 1 Synaptobrevin AKNA PF12443.8 EXF75327.1 - 0.061 14.0 0.1 0.13 13.0 0.1 1.6 1 1 0 1 1 1 0 AT-hook-containing transcription factor NAT PF04768.13 EXF75328.1 - 6e-50 169.2 0.1 2.4e-49 167.2 0.0 2.0 2 0 0 2 2 2 1 NAT, N-acetyltransferase, of N-acetylglutamate synthase AA_kinase PF00696.28 EXF75328.1 - 7.6e-32 110.8 0.1 1.9e-30 106.2 0.0 2.2 2 0 0 2 2 2 1 Amino acid kinase family Semialdhyde_dh PF01118.24 EXF75328.1 - 9.5e-30 103.5 0.0 2.6e-29 102.1 0.0 1.8 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain DapB_N PF01113.20 EXF75328.1 - 0.034 14.3 0.0 0.088 12.9 0.0 1.8 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Sacchrp_dh_NADP PF03435.18 EXF75328.1 - 0.17 12.2 0.0 0.36 11.1 0.0 1.6 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain HET PF06985.11 EXF75329.1 - 2.4e-12 47.4 3.5 9e-10 39.1 0.4 2.4 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) DUF2682 PF10909.8 EXF75329.1 - 0.037 14.5 0.2 0.1 13.1 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2682) Fasciclin PF02469.22 EXF75330.1 - 2.5e-44 150.6 5.4 9.6e-23 80.8 0.2 2.1 2 0 0 2 2 2 2 Fasciclin domain DUF285 PF03382.14 EXF75330.1 - 0.069 12.9 0.2 0.13 12.0 0.2 1.4 1 0 0 1 1 1 0 Mycoplasma protein of unknown function, DUF285 DUF3176 PF11374.8 EXF75332.1 - 1.2e-29 102.7 1.7 2.2e-29 101.8 1.0 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF3176) NiFe_hyd_3_EhaA PF17367.2 EXF75332.1 - 0.076 13.2 0.4 0.22 11.7 0.4 1.7 1 0 0 1 1 1 0 NiFe-hydrogenase-type-3 Eha complex subunit A Cellulase PF00150.18 EXF75333.1 - 3.4e-14 53.0 2.0 8e-14 51.7 2.0 1.6 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) FAD_binding_4 PF01565.23 EXF75334.1 - 5.8e-24 84.4 1.6 1.6e-23 83.0 1.0 2.0 2 0 0 2 2 2 1 FAD binding domain BBE PF08031.12 EXF75334.1 - 4.2e-11 42.8 0.0 2.1e-10 40.6 0.0 2.0 2 0 0 2 2 2 1 Berberine and berberine like MMR_HSR1 PF01926.23 EXF75335.1 - 9.8e-07 28.9 0.0 1.4e-06 28.3 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.16 EXF75335.1 - 1.4e-05 24.6 0.0 2.1e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 AIG1 family AAA_33 PF13671.6 EXF75335.1 - 5.6e-05 23.3 0.0 0.00011 22.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EXF75335.1 - 5.7e-05 23.4 0.0 0.00025 21.3 0.0 2.2 2 1 0 2 2 1 1 AAA domain Septin PF00735.18 EXF75335.1 - 7.7e-05 22.1 0.0 0.00013 21.4 0.0 1.4 1 0 0 1 1 1 1 Septin AAA_14 PF13173.6 EXF75335.1 - 0.00048 20.2 0.0 0.0007 19.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EXF75335.1 - 0.00094 19.6 0.0 0.0022 18.4 0.0 1.9 1 1 0 1 1 1 1 AAA ATPase domain ABC_tran PF00005.27 EXF75335.1 - 0.0037 17.8 0.0 0.0048 17.4 0.0 1.3 1 0 0 1 1 1 1 ABC transporter SRPRB PF09439.10 EXF75335.1 - 0.0053 16.2 0.0 0.0071 15.8 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA PF00004.29 EXF75335.1 - 0.0054 17.2 0.0 0.0083 16.5 0.0 1.6 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ATPase_2 PF01637.18 EXF75335.1 - 0.0085 16.0 0.0 0.016 15.1 0.0 1.5 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea Dynamin_N PF00350.23 EXF75335.1 - 0.011 15.8 0.3 0.86 9.6 0.1 2.4 1 1 1 2 2 2 0 Dynamin family FeoB_N PF02421.18 EXF75335.1 - 0.018 14.6 0.0 0.028 13.9 0.0 1.4 1 0 0 1 1 1 0 Ferrous iron transport protein B NACHT PF05729.12 EXF75335.1 - 0.018 14.9 0.0 0.03 14.2 0.0 1.3 1 0 0 1 1 1 0 NACHT domain Rad17 PF03215.15 EXF75335.1 - 0.024 14.6 0.0 0.038 13.9 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain ATP_bind_1 PF03029.17 EXF75335.1 - 0.026 14.3 0.1 0.099 12.4 0.1 1.9 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein RsgA_GTPase PF03193.16 EXF75335.1 - 0.033 14.1 0.0 0.072 13.0 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase AAA_18 PF13238.6 EXF75335.1 - 0.034 14.7 0.1 0.18 12.4 0.1 2.1 1 1 0 1 1 1 0 AAA domain tRNA_lig_kinase PF08303.11 EXF75335.1 - 0.035 14.2 0.0 0.064 13.3 0.0 1.4 1 0 0 1 1 1 0 tRNA ligase kinase domain AAA_28 PF13521.6 EXF75335.1 - 0.038 14.2 0.0 0.08 13.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain Pox_A32 PF04665.12 EXF75335.1 - 0.046 13.2 0.0 0.09 12.2 0.0 1.4 1 0 0 1 1 1 0 Poxvirus A32 protein AAA_24 PF13479.6 EXF75335.1 - 0.069 12.9 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain Ras PF00071.22 EXF75335.1 - 0.071 12.7 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 Ras family Viral_helicase1 PF01443.18 EXF75335.1 - 0.077 12.7 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase PduV-EutP PF10662.9 EXF75335.1 - 0.079 12.7 0.0 0.26 11.0 0.0 1.9 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation GTP_EFTU PF00009.27 EXF75335.1 - 0.096 12.2 0.1 2.7 7.5 0.1 2.3 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain RNA_helicase PF00910.22 EXF75335.1 - 0.12 12.8 0.0 0.27 11.6 0.0 1.6 1 0 0 1 1 1 0 RNA helicase PRK PF00485.18 EXF75335.1 - 0.12 12.1 0.0 0.47 10.2 0.0 1.9 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family MobB PF03205.14 EXF75335.1 - 0.15 11.9 0.0 1.2 9.1 0.0 2.1 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_15 PF13175.6 EXF75335.1 - 0.15 11.7 0.0 0.19 11.4 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain CAP_N PF01213.19 EXF75335.1 - 0.51 9.8 3.3 0.87 9.0 3.3 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal PRIMA1 PF16101.5 EXF75335.1 - 2.6 8.1 7.1 4.6 7.3 7.1 1.3 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Metallophos PF00149.28 EXF75336.1 - 3.4e-09 37.5 2.7 1.9e-08 35.1 2.7 2.0 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EXF75336.1 - 9.5e-06 25.9 1.8 8.8e-05 22.7 1.3 2.3 1 1 1 2 2 2 1 Calcineurin-like phosphoesterase superfamily domain TAL_FSA PF00923.19 EXF75337.1 - 1.1e-93 313.7 1.6 1.3e-93 313.5 1.6 1.0 1 0 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase SNase PF00565.17 EXF75338.1 - 2.6e-74 246.6 3.3 5e-22 78.4 0.0 5.4 5 0 0 5 5 5 5 Staphylococcal nuclease homologue TUDOR PF00567.24 EXF75338.1 - 4.3e-23 81.6 0.0 8.4e-23 80.7 0.0 1.4 1 0 0 1 1 1 1 Tudor domain SMN PF06003.12 EXF75338.1 - 6.1e-06 25.7 0.0 3.3e-05 23.3 0.0 2.1 2 0 0 2 2 2 1 Survival motor neuron protein (SMN) Sod_Cu PF00080.20 EXF75339.1 - 2.6e-45 154.1 6.9 3e-45 153.9 6.9 1.0 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) CNH PF00780.22 EXF75340.1 - 3.3e-67 227.0 0.0 5.6e-67 226.2 0.0 1.2 1 0 0 1 1 1 1 CNH domain RhoGEF PF00621.20 EXF75340.1 - 9.6e-33 113.9 0.9 1.7e-32 113.1 0.9 1.5 1 0 0 1 1 1 1 RhoGEF domain PH_5 PF15405.6 EXF75340.1 - 3.5e-13 49.8 0.0 1.3e-12 48.0 0.0 2.0 1 1 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 EXF75340.1 - 0.00015 22.3 0.0 0.0011 19.4 0.0 2.3 2 0 0 2 2 2 1 PH domain PH_13 PF16652.5 EXF75340.1 - 0.17 11.7 0.1 0.76 9.6 0.0 2.1 2 0 0 2 2 2 0 Pleckstrin homology domain PH_16 PF17838.1 EXF75340.1 - 0.18 11.6 0.1 22 4.9 0.0 2.4 2 0 0 2 2 2 0 PH domain Tropomyosin PF00261.20 EXF75340.1 - 0.53 9.6 5.1 1.1 8.6 5.1 1.3 1 0 0 1 1 1 0 Tropomyosin Beta-lactamase PF00144.24 EXF75341.1 - 7e-30 104.4 1.4 1e-29 103.9 1.4 1.2 1 0 0 1 1 1 1 Beta-lactamase Pkinase PF00069.25 EXF75344.1 - 2.5e-26 92.6 0.0 3.2e-26 92.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF75344.1 - 7.1e-14 51.7 0.0 9.9e-14 51.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EXF75344.1 - 4.1e-09 35.7 0.0 6.6e-09 35.0 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EXF75344.1 - 0.00017 21.6 0.0 0.0015 18.5 0.0 2.2 1 1 0 2 2 2 1 Phosphotransferase enzyme family Exo_endo_phos PF03372.23 EXF75345.1 - 7.8e-06 25.6 0.0 1.2e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Pkinase PF00069.25 EXF75346.1 - 2.1e-67 227.3 0.0 2.5e-67 227.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF75346.1 - 2.1e-31 109.1 0.0 2.8e-31 108.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EXF75346.1 - 6.9e-05 22.3 0.0 0.00016 21.1 0.0 1.6 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 EXF75346.1 - 0.0028 17.6 0.1 0.0094 15.9 0.0 1.8 1 1 1 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EXF75346.1 - 0.064 12.0 0.0 0.097 11.4 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Haspin_kinase PF12330.8 EXF75346.1 - 0.077 11.9 0.0 0.1 11.5 0.0 1.1 1 0 0 1 1 1 0 Haspin like kinase domain Seadorna_VP7 PF07387.11 EXF75346.1 - 0.15 11.1 0.0 0.23 10.5 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 RabGAP-TBC PF00566.18 EXF75347.1 - 2e-47 161.6 0.0 3.5e-47 160.8 0.0 1.4 1 0 0 1 1 1 1 Rab-GTPase-TBC domain EF-hand_6 PF13405.6 EXF75347.1 - 1e-06 28.2 0.5 0.014 15.3 0.3 3.7 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 EXF75347.1 - 0.00018 21.9 0.1 0.0019 18.6 0.1 2.7 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.32 EXF75347.1 - 0.00081 18.8 1.6 0.074 12.6 0.6 3.5 3 0 0 3 3 3 1 EF hand GRAM PF02893.20 EXF75347.1 - 0.009 15.9 0.0 0.019 14.8 0.0 1.5 1 0 0 1 1 1 1 GRAM domain EF-hand_5 PF13202.6 EXF75347.1 - 0.039 13.5 0.2 0.14 11.7 0.2 2.0 1 0 0 1 1 1 0 EF hand WSC PF01822.19 EXF75348.1 - 3.4e-16 59.2 48.5 4.5e-11 42.8 1.0 5.1 5 2 0 5 5 5 3 WSC domain FAD_binding_4 PF01565.23 EXF75349.1 - 1.2e-19 70.4 1.9 1.8e-19 69.9 1.9 1.2 1 0 0 1 1 1 1 FAD binding domain ALO PF04030.14 EXF75349.1 - 2.8e-13 50.3 0.6 8.8e-12 45.4 0.6 2.4 1 1 0 1 1 1 1 D-arabinono-1,4-lactone oxidase FAD-oxidase_C PF02913.19 EXF75349.1 - 0.022 14.4 0.0 2 8.0 0.0 2.3 2 0 0 2 2 2 0 FAD linked oxidases, C-terminal domain p450 PF00067.22 EXF75350.1 - 3.8e-50 171.0 0.0 4.6e-50 170.7 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Dehydrin PF00257.19 EXF75350.1 - 0.0085 16.7 1.1 0.015 15.8 1.1 1.3 1 0 0 1 1 1 1 Dehydrin TAXi_C PF14541.6 EXF75350.1 - 0.031 14.1 0.0 0.052 13.3 0.0 1.3 1 0 0 1 1 1 0 Xylanase inhibitor C-terminal adh_short PF00106.25 EXF75351.1 - 6.7e-16 58.3 0.0 9.6e-16 57.8 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF75351.1 - 1.5e-09 37.7 0.0 2.6e-09 37.0 0.0 1.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Pal1 PF08316.11 EXF75352.1 - 6.1e-44 150.1 0.5 1.6e-43 148.8 0.5 1.7 1 0 0 1 1 1 1 Pal1 cell morphology protein Fasciclin PF02469.22 EXF75354.1 - 1.8e-39 134.9 0.0 6.1e-20 71.7 0.0 2.2 2 0 0 2 2 2 2 Fasciclin domain Pmp3 PF01679.17 EXF75355.1 - 0.14 12.3 0.0 0.25 11.6 0.0 1.4 1 0 0 1 1 1 0 Proteolipid membrane potential modulator DUF3433 PF11915.8 EXF75356.1 - 7e-29 100.1 21.1 3.4e-26 91.5 6.1 4.3 6 0 0 6 6 6 2 Protein of unknown function (DUF3433) DUF2457 PF10446.9 EXF75356.1 - 4.3 6.4 8.7 9.7 5.2 8.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Ank_3 PF13606.6 EXF75360.1 - 3.5e-11 42.3 0.6 0.29 11.8 0.0 6.1 6 0 0 6 6 6 2 Ankyrin repeat Ank_2 PF12796.7 EXF75360.1 - 1.3e-09 38.5 0.1 0.039 14.6 0.1 4.1 2 1 0 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EXF75360.1 - 7.3e-08 32.5 1.7 0.12 12.8 0.0 4.7 5 0 0 5 5 5 3 Ankyrin repeats (many copies) Ank PF00023.30 EXF75360.1 - 6.6e-05 23.2 0.1 0.51 10.9 0.0 3.9 4 0 0 4 4 4 2 Ankyrin repeat Ank_4 PF13637.6 EXF75360.1 - 0.0014 19.1 0.3 2.1 9.1 0.0 4.1 5 0 0 5 5 5 1 Ankyrin repeats (many copies) HET PF06985.11 EXF75361.1 - 4.7e-12 46.5 0.3 1.2e-11 45.1 0.1 1.9 2 0 0 2 2 2 1 Heterokaryon incompatibility protein (HET) Aminotran_5 PF00266.19 EXF75362.1 - 8e-15 54.7 0.0 1.1e-14 54.1 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V SepSecS PF05889.13 EXF75362.1 - 0.0013 17.5 0.0 0.0018 17.0 0.0 1.1 1 0 0 1 1 1 1 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS Aminotran_1_2 PF00155.21 EXF75362.1 - 0.0013 17.9 0.0 0.0077 15.4 0.0 1.9 1 1 0 1 1 1 1 Aminotransferase class I and II SAICAR_synt PF01259.18 EXF75363.1 - 4.5e-101 337.7 0.0 5.2e-101 337.5 0.0 1.0 1 0 0 1 1 1 1 SAICAR synthetase Asp PF00026.23 EXF75364.1 - 8.2e-63 212.7 5.5 1.2e-62 212.2 5.5 1.2 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EXF75364.1 - 8.1e-11 42.5 2.6 4.5e-10 40.0 2.6 2.1 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal gag-asp_proteas PF13975.6 EXF75364.1 - 0.00026 21.5 0.7 0.66 10.6 0.1 3.6 3 1 0 3 3 3 2 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 EXF75364.1 - 0.00093 19.8 2.0 1.9 9.2 0.9 3.4 2 1 0 2 2 2 2 Aspartyl protease AIM24 PF01987.17 EXF75364.1 - 0.012 15.4 0.1 0.035 13.9 0.1 1.9 1 1 0 1 1 1 0 Mitochondrial biogenesis AIM24 Paramyxo_P_V_N PF13825.6 EXF75364.1 - 0.46 9.9 3.2 0.92 8.9 3.2 1.4 1 0 0 1 1 1 0 Paramyxovirus structural protein V/P N-terminus PHD PF00628.29 EXF75365.1 - 6.3e-12 45.2 5.7 1.9e-11 43.6 5.7 1.9 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 EXF75365.1 - 0.024 14.2 1.0 0.057 13.0 1.0 1.7 1 0 0 1 1 1 0 PHD-finger PHD_4 PF16866.5 EXF75365.1 - 0.047 13.8 4.0 0.14 12.3 4.0 1.9 1 0 0 1 1 1 0 PHD-finger zf-RING_2 PF13639.6 EXF75365.1 - 2 8.8 6.2 5.2 7.5 6.2 1.7 1 0 0 1 1 1 0 Ring finger domain PHD_3 PF13922.6 EXF75365.1 - 9.8 6.6 7.1 0.54 10.7 0.8 2.2 2 0 0 2 2 2 0 PHD domain of transcriptional enhancer, Asx SCO1-SenC PF02630.14 EXF75366.1 - 1e-50 171.1 0.1 1.4e-50 170.7 0.1 1.2 1 0 0 1 1 1 1 SCO1/SenC AhpC-TSA PF00578.21 EXF75366.1 - 1.4e-07 31.4 0.0 2.9e-07 30.4 0.0 1.5 1 1 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EXF75366.1 - 0.0007 19.3 0.0 0.019 14.7 0.0 2.2 1 1 0 1 1 1 1 Redoxin Thioredoxin_8 PF13905.6 EXF75366.1 - 0.011 16.1 0.0 0.019 15.3 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin-like Hydrolase_6 PF13344.6 EXF75367.1 - 1.9e-24 85.7 0.0 3.6e-24 84.8 0.0 1.5 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EXF75367.1 - 6e-18 64.7 0.1 1.4e-17 63.5 0.1 1.7 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 EXF75367.1 - 0.0004 20.7 0.3 1.1 9.4 0.0 3.9 2 1 2 4 4 4 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EXF75367.1 - 0.14 12.2 0.0 22 5.1 0.0 2.7 2 1 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Choline_kinase PF01633.20 EXF75368.1 - 9.2e-57 192.1 0.5 1.3e-55 188.3 0.0 2.3 2 0 0 2 2 2 1 Choline/ethanolamine kinase Choline_kin_N PF04428.14 EXF75368.1 - 6e-22 77.1 0.0 1.2e-21 76.2 0.0 1.5 1 0 0 1 1 1 1 Choline kinase N terminus APH PF01636.23 EXF75368.1 - 0.00043 20.3 0.0 0.00043 20.3 0.0 2.6 3 1 0 3 3 3 1 Phosphotransferase enzyme family G-patch PF01585.23 EXF75369.1 - 8.7e-12 44.7 2.5 1.6e-11 43.9 2.5 1.5 1 0 0 1 1 1 1 G-patch domain RRM_1 PF00076.22 EXF75369.1 - 1.6e-06 27.9 0.1 0.01 15.7 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) G-patch_2 PF12656.7 EXF75369.1 - 9.2e-06 25.7 2.9 3.3e-05 23.9 2.9 2.0 1 0 0 1 1 1 1 G-patch domain zf-RanBP PF00641.18 EXF75369.1 - 4e-05 22.8 4.3 0.00011 21.4 4.3 1.7 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others RED_N PF07808.13 EXF75369.1 - 0.0037 16.9 4.0 0.0037 16.9 4.0 2.3 2 0 0 2 2 2 1 RED-like protein N-terminal region zf-C2H2_2 PF12756.7 EXF75369.1 - 0.0097 16.2 0.6 0.027 14.8 0.6 1.7 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.8 EXF75369.1 - 10 6.6 7.8 1.5 9.2 3.6 1.8 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding MoaE PF02391.17 EXF75370.1 - 1.5e-38 131.6 0.0 1.8e-38 131.3 0.0 1.1 1 0 0 1 1 1 1 MoaE protein BTB PF00651.31 EXF75371.1 - 9.3e-24 83.8 0.8 3.6e-13 49.7 0.4 3.1 3 0 0 3 3 3 2 BTB/POZ domain Ank_4 PF13637.6 EXF75371.1 - 0.0057 17.2 0.0 0.016 15.8 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EXF75371.1 - 0.15 12.7 0.0 0.99 10.0 0.0 2.3 1 1 0 1 1 1 0 Ankyrin repeats (3 copies) Pkinase PF00069.25 EXF75372.1 - 1.7e-54 185.0 0.3 4.8e-35 121.2 0.0 2.4 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EXF75372.1 - 8.1e-37 126.9 0.0 4.4e-36 124.5 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EXF75372.1 - 0.0004 19.8 0.0 0.001 18.5 0.0 1.6 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EXF75372.1 - 0.09 12.7 0.6 0.48 10.3 0.0 2.3 3 0 0 3 3 3 0 Phosphotransferase enzyme family DUF3896 PF13035.6 EXF75372.1 - 0.13 12.5 0.9 0.35 11.1 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3896) FAM76 PF16046.5 EXF75372.1 - 0.37 10.1 1.9 0.81 9.0 1.9 1.6 1 0 0 1 1 1 0 FAM76 protein OmpH PF03938.14 EXF75372.1 - 1.7 9.0 6.1 4.1 7.7 6.1 1.6 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) HIP1_clath_bdg PF16515.5 EXF75372.1 - 9.3 6.9 17.0 6.5 7.4 12.4 2.7 2 1 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 zf-C2H2 PF00096.26 EXF75373.1 - 9.6e-09 35.2 12.2 0.00047 20.5 2.2 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EXF75373.1 - 1.3e-05 25.4 11.1 3.4e-05 24.1 2.0 3.4 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 EXF75373.1 - 0.00011 22.7 11.4 0.093 13.6 2.4 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EXF75373.1 - 0.01 15.8 0.9 0.01 15.8 0.9 2.1 2 0 0 2 2 2 0 C2H2-type zinc finger zf-met PF12874.7 EXF75373.1 - 0.028 14.8 3.7 0.072 13.5 1.6 2.4 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EXF75373.1 - 0.077 13.3 0.4 0.077 13.3 0.4 2.4 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Lactonase PF10282.9 EXF75374.1 - 2.3e-24 86.3 1.2 4.5e-24 85.3 1.2 1.5 1 1 0 1 1 1 1 Lactonase, 7-bladed beta-propeller DAPG_hydrolase PF18089.1 EXF75375.1 - 4.4e-80 268.4 1.0 5.5e-80 268.1 1.0 1.1 1 0 0 1 1 1 1 DAPG hydrolase PhiG domain Oxidored_FMN PF00724.20 EXF75376.1 - 1.7e-36 126.2 0.0 2.2e-36 125.8 0.0 1.1 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family His_biosynth PF00977.21 EXF75376.1 - 0.00092 18.7 0.0 0.0014 18.1 0.0 1.2 1 0 0 1 1 1 1 Histidine biosynthesis protein Thoc2 PF11732.8 EXF75376.1 - 0.061 13.4 0.0 0.11 12.6 0.0 1.3 1 0 0 1 1 1 0 Transcription- and export-related complex subunit Ecm33 PF12454.8 EXF75377.1 - 0.83 9.9 4.9 4.7 7.4 0.2 2.6 2 0 0 2 2 2 0 GPI-anchored cell wall organization protein RTA1 PF04479.13 EXF75378.1 - 6.2e-60 202.4 9.4 1e-59 201.6 9.4 1.3 1 0 0 1 1 1 1 RTA1 like protein NnrS PF05940.12 EXF75378.1 - 0.059 12.7 15.0 0.47 9.8 11.2 2.0 1 1 1 2 2 2 0 NnrS protein DUF3493 PF11998.8 EXF75378.1 - 0.45 10.7 3.3 15 5.8 0.2 3.6 3 1 0 3 3 3 0 Low psii accumulation1 / Rep27 DUF3007 PF11460.8 EXF75378.1 - 2.4 8.5 4.4 1.9 8.8 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3007) Whi5 PF08528.11 EXF75379.1 - 4.8e-09 35.6 0.1 8.7e-09 34.8 0.1 1.5 1 0 0 1 1 1 1 Whi5 like TFIIA PF03153.13 EXF75379.1 - 0.5 10.3 27.1 0.71 9.8 27.1 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit KIX_2 PF16987.5 EXF75380.1 - 2.5e-05 24.2 0.2 0.00021 21.2 0.2 2.8 1 0 0 1 1 1 1 KIX domain GLEYA PF10528.9 EXF75380.1 - 0.91 10.0 3.4 2.3 8.7 0.1 2.7 2 0 0 2 2 2 0 GLEYA domain Peptidase_M18 PF02127.15 EXF75382.1 - 1.5e-172 574.3 0.0 5.2e-172 572.5 0.0 1.7 1 1 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.14 EXF75382.1 - 6.1e-06 25.5 0.2 0.0017 17.4 0.0 2.7 3 0 0 3 3 3 2 M42 glutamyl aminopeptidase DUF3552 PF12072.8 EXF75383.1 - 0.031 13.7 8.2 0.04 13.3 8.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) Presenilin PF01080.17 EXF75383.1 - 5.8 5.6 4.8 6.4 5.4 4.8 1.1 1 0 0 1 1 1 0 Presenilin DUF2264 PF10022.9 EXF75385.1 - 2.5e-134 447.9 0.4 3.2e-134 447.5 0.4 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2264) FH2 PF02181.23 EXF75386.1 - 1.7e-85 287.4 5.0 1.7e-85 287.4 5.0 1.9 2 0 0 2 2 2 1 Formin Homology 2 Domain Drf_GBD PF06371.13 EXF75386.1 - 3.4e-64 215.9 0.2 1.4e-63 213.9 0.0 2.2 2 0 0 2 2 2 1 Diaphanous GTPase-binding Domain Drf_FH3 PF06367.16 EXF75386.1 - 4.8e-52 176.4 4.0 8.8e-52 175.6 2.1 2.5 2 1 1 3 3 3 1 Diaphanous FH3 Domain Bap31_Bap29_C PF18035.1 EXF75386.1 - 9.4 6.3 7.5 12 6.0 5.1 2.4 2 0 0 2 2 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain zf-RING_2 PF13639.6 EXF75387.1 - 7.7e-08 32.5 5.7 7.7e-08 32.5 5.7 2.8 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4 PF00097.25 EXF75387.1 - 1.7e-05 24.6 0.6 1.7e-05 24.6 0.6 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EXF75387.1 - 9.2e-05 22.1 0.2 0.00077 19.2 0.0 2.6 2 1 0 2 2 2 1 RING-like zinc finger zf-rbx1 PF12678.7 EXF75387.1 - 0.00021 21.5 5.9 0.00021 21.5 5.9 2.3 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 EXF75387.1 - 0.0004 20.2 6.7 0.0015 18.3 3.3 3.1 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EXF75387.1 - 0.00049 20.1 0.0 0.00049 20.1 0.0 2.6 2 1 1 3 3 3 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 EXF75387.1 - 0.0038 17.3 4.5 0.0038 17.3 4.5 1.9 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.6 EXF75387.1 - 0.023 14.6 2.9 0.023 14.6 2.9 2.8 3 0 0 3 3 3 0 zinc-RING finger domain Prok-RING_4 PF14447.6 EXF75387.1 - 0.11 12.4 6.0 0.067 13.1 1.9 2.5 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 NDUF_B12 PF08122.12 EXF75387.1 - 4.3 7.5 9.2 3.2 7.9 2.6 3.6 4 0 0 4 4 4 0 NADH-ubiquinone oxidoreductase B12 subunit family Hus1 PF04005.12 EXF75388.1 - 2.7e-88 295.9 0.0 3.1e-88 295.7 0.0 1.0 1 0 0 1 1 1 1 Hus1-like protein MMtag PF10159.9 EXF75389.1 - 1e-30 105.8 3.6 1e-30 105.8 3.6 2.6 3 1 0 3 3 3 1 Multiple myeloma tumor-associated Med6 PF04934.14 EXF75390.1 - 1.7e-36 125.0 0.0 2.4e-36 124.5 0.0 1.2 1 0 0 1 1 1 1 MED6 mediator sub complex component NmrA PF05368.13 EXF75391.1 - 1.1e-17 64.4 0.0 3e-17 63.0 0.0 1.7 1 1 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EXF75391.1 - 3.9e-12 46.4 0.0 1e-10 41.9 0.0 2.1 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EXF75391.1 - 0.011 15.3 0.0 0.027 13.9 0.0 1.6 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.24 EXF75391.1 - 0.016 15.6 0.0 0.031 14.7 0.0 1.5 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain KR PF08659.10 EXF75391.1 - 0.17 11.8 0.0 0.31 10.9 0.0 1.4 1 0 0 1 1 1 0 KR domain adh_short_C2 PF13561.6 EXF75392.1 - 1.4e-43 149.1 0.0 2e-28 99.6 0.0 2.2 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF75392.1 - 2.1e-34 118.7 0.0 3.3e-34 118.1 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EXF75392.1 - 2e-08 34.3 0.0 3.5e-08 33.6 0.0 1.5 1 1 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EXF75392.1 - 0.0058 15.8 0.0 0.0088 15.2 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.21 EXF75392.1 - 0.087 12.3 0.0 0.16 11.4 0.0 1.5 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family HA2 PF04408.23 EXF75393.1 - 4e-26 91.4 0.0 4e-26 91.4 0.0 2.7 2 1 0 2 2 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 EXF75393.1 - 4.8e-12 46.2 0.0 6.6e-11 42.5 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.16 EXF75393.1 - 1.4e-10 41.3 0.0 3e-10 40.3 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.29 EXF75393.1 - 1e-09 38.4 0.0 2.9e-09 36.9 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EXF75393.1 - 4e-05 23.9 0.1 0.00017 21.8 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EXF75393.1 - 0.00028 20.7 0.0 0.00066 19.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EXF75393.1 - 0.00036 20.9 0.0 0.0008 19.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain PhoH PF02562.16 EXF75393.1 - 0.011 15.2 0.1 0.026 14.0 0.0 1.6 2 0 0 2 2 2 0 PhoH-like protein T2SSE PF00437.20 EXF75393.1 - 0.02 14.0 0.0 0.051 12.6 0.0 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein ATPase PF06745.13 EXF75393.1 - 0.033 13.5 0.7 0.067 12.5 0.1 1.8 2 0 0 2 2 2 0 KaiC AAA_33 PF13671.6 EXF75393.1 - 0.27 11.4 2.3 0.78 9.9 0.1 2.4 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 EXF75393.1 - 0.4 11.2 3.2 14 6.2 0.0 2.6 2 0 0 2 2 2 0 ABC transporter ResIII PF04851.15 EXF75393.1 - 0.66 10.0 0.0 0.66 10.0 0.0 2.9 4 0 0 4 4 3 0 Type III restriction enzyme, res subunit PAC3 PF10178.9 EXF75394.1 - 4.9e-05 23.4 0.0 6.7e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 Proteasome assembly chaperone 3 CoA_transf_3 PF02515.17 EXF75395.1 - 4.6e-69 233.3 0.0 5.6e-69 233.0 0.0 1.1 1 0 0 1 1 1 1 CoA-transferase family III Nudix_N PF12535.8 EXF75395.1 - 0.034 13.8 0.0 0.091 12.4 0.0 1.7 1 0 0 1 1 1 0 Hydrolase of X-linked nucleoside diphosphate N terminal adh_short PF00106.25 EXF75396.1 - 4e-20 72.1 0.2 4.8e-17 62.0 0.1 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EXF75396.1 - 2.1e-10 40.6 0.3 2.6e-09 37.0 0.3 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF75396.1 - 2.2e-05 24.4 0.0 3.7e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 KR domain Dynamin_M PF01031.20 EXF75397.1 - 2.5e-101 338.7 0.0 4.6e-101 337.8 0.0 1.5 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.23 EXF75397.1 - 7.4e-57 192.1 0.0 1.3e-56 191.2 0.0 1.4 1 0 0 1 1 1 1 Dynamin family GED PF02212.18 EXF75397.1 - 6.3e-30 103.2 4.4 6.3e-30 103.2 4.4 2.2 2 0 0 2 2 2 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 EXF75397.1 - 2.2e-05 24.5 0.2 0.00023 21.2 0.2 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase DUF2226 PF09987.9 EXF75397.1 - 0.043 13.2 0.1 11 5.3 0.2 2.4 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2226) AAA_15 PF13175.6 EXF75397.1 - 0.049 13.3 0.6 2.4 7.8 0.1 2.4 2 0 0 2 2 2 0 AAA ATPase domain WD40 PF00400.32 EXF75398.1 - 4.1e-15 55.9 14.2 5.7e-05 23.8 0.2 6.7 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EXF75398.1 - 2.9e-10 40.3 0.6 0.12 12.7 0.0 4.7 2 2 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_3 PF15911.5 EXF75398.1 - 0.0053 16.7 0.0 0.087 12.8 0.0 2.6 2 0 0 2 2 2 1 WD domain, G-beta repeat Abhydrolase_2 PF02230.16 EXF75399.1 - 5.6e-11 42.7 0.0 5.7e-10 39.4 0.0 2.2 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase HAUS-augmin3 PF14932.6 EXF75400.1 - 0.018 14.6 2.3 0.026 14.1 2.3 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 DUF3450 PF11932.8 EXF75400.1 - 0.042 13.1 2.6 0.07 12.4 2.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) LCCL PF03815.19 EXF75402.1 - 1.1e-20 73.5 0.3 1.8e-20 72.8 0.3 1.3 1 0 0 1 1 1 1 LCCL domain AMP-binding PF00501.28 EXF75403.1 - 1.1e-71 241.6 0.0 1.8e-71 241.0 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme NAD_binding_4 PF07993.12 EXF75403.1 - 6.8e-59 199.1 0.0 1.3e-58 198.2 0.0 1.5 1 0 0 1 1 1 1 Male sterility protein adh_short PF00106.25 EXF75403.1 - 1e-52 178.5 3.9 1.2e-52 178.2 2.2 1.9 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF75403.1 - 1.2e-39 136.3 1.6 2.2e-39 135.4 1.6 1.4 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF75403.1 - 3.8e-20 72.5 2.7 2.7e-15 56.7 1.2 2.4 2 0 0 2 2 2 2 KR domain Epimerase PF01370.21 EXF75403.1 - 5.6e-15 55.5 1.3 1.1e-08 34.8 0.0 3.6 3 2 0 3 3 3 2 NAD dependent epimerase/dehydratase family PP-binding PF00550.25 EXF75403.1 - 6.1e-11 42.5 0.0 1.6e-10 41.2 0.0 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site NAD_binding_10 PF13460.6 EXF75403.1 - 3.8e-06 26.9 1.0 0.00028 20.8 0.6 2.8 3 0 0 3 3 3 1 NAD(P)H-binding RmlD_sub_bind PF04321.17 EXF75403.1 - 6.3e-06 25.5 2.2 0.011 14.9 0.1 4.0 3 1 0 3 3 3 1 RmlD substrate binding domain 3Beta_HSD PF01073.19 EXF75403.1 - 8.4e-06 25.0 0.3 0.00074 18.6 0.0 3.0 2 1 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 EXF75403.1 - 8.5e-05 21.8 1.1 0.46 9.6 0.0 3.2 3 1 0 3 3 3 2 Polysaccharide biosynthesis protein AMP-binding_C PF13193.6 EXF75403.1 - 0.0024 18.8 0.1 0.02 15.9 0.0 2.7 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain GDP_Man_Dehyd PF16363.5 EXF75403.1 - 0.0051 16.3 0.1 1.8 7.9 0.0 2.5 2 0 0 2 2 2 2 GDP-mannose 4,6 dehydratase DFP PF04127.15 EXF75403.1 - 0.0071 16.2 1.1 0.017 15.0 1.1 1.5 1 0 0 1 1 1 1 DNA / pantothenate metabolism flavoprotein THF_DHG_CYH_C PF02882.19 EXF75403.1 - 0.01 15.2 0.2 0.027 13.8 0.2 1.7 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain NmrA PF05368.13 EXF75403.1 - 0.01 15.4 2.9 2.7 7.5 0.0 2.7 3 0 0 3 3 3 0 NmrA-like family TGT PF01702.18 EXF75404.1 - 1.4e-56 192.2 0.0 1.6e-47 162.3 0.0 2.0 1 1 1 2 2 2 2 Queuine tRNA-ribosyltransferase NDUFA12 PF05071.16 EXF75405.1 - 2.8e-31 108.2 1.3 3.4e-31 107.9 1.3 1.1 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase subunit NDUFA12 PLDc_2 PF13091.6 EXF75406.1 - 1.7e-16 60.3 0.0 7.7e-08 32.3 0.0 2.5 2 1 0 2 2 2 2 PLD-like domain PLDc PF00614.22 EXF75406.1 - 3.9e-08 33.1 2.6 0.0047 17.1 0.4 3.1 2 1 0 2 2 2 2 Phospholipase D Active site motif PhzC-PhzF PF02567.16 EXF75406.1 - 0.055 12.9 0.0 0.09 12.2 0.0 1.3 1 0 0 1 1 1 0 Phenazine biosynthesis-like protein DnaG_DnaB_bind PF08278.11 EXF75406.1 - 0.056 14.0 0.0 0.16 12.6 0.0 1.7 2 0 0 2 2 2 0 DNA primase DnaG DnaB-binding IF-2B PF01008.17 EXF75408.1 - 8.8e-47 159.6 0.0 2.2e-46 158.3 0.0 1.6 1 1 0 1 1 1 1 Initiation factor 2 subunit family CNTF PF01110.17 EXF75408.1 - 0.049 13.0 0.2 0.17 11.2 0.0 1.9 2 0 0 2 2 2 0 Ciliary neurotrophic factor IF3_C PF00707.22 EXF75409.1 - 8.2e-09 35.3 0.6 1.7e-08 34.3 0.6 1.5 1 0 0 1 1 1 1 Translation initiation factor IF-3, C-terminal domain mIF3 PF14877.6 EXF75409.1 - 1.1e-06 28.4 0.9 4.2e-05 23.3 0.9 2.1 1 1 0 1 1 1 1 Mitochondrial translation initiation factor IF3_N PF05198.16 EXF75409.1 - 0.0019 18.4 0.3 0.0019 18.4 0.3 2.3 2 1 1 3 3 3 1 Translation initiation factor IF-3, N-terminal domain Ribosomal_L36e PF01158.18 EXF75409.1 - 0.01 16.1 0.5 0.01 16.1 0.5 1.7 2 0 0 2 2 2 0 Ribosomal protein L36e Peptidase_S24 PF00717.23 EXF75410.1 - 1.2e-06 28.3 0.1 1.9e-06 27.7 0.1 1.3 1 0 0 1 1 1 1 Peptidase S24-like Peptidase_S26 PF10502.9 EXF75410.1 - 1e-05 25.3 0.0 0.00029 20.6 0.0 2.4 1 1 1 2 2 2 1 Signal peptidase, peptidase S26 Arm PF00514.23 EXF75411.1 - 1.6e-75 247.1 32.7 9e-13 47.8 0.2 11.3 11 1 0 11 11 11 9 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 EXF75411.1 - 3e-18 65.9 11.3 0.00014 22.3 0.2 8.1 7 1 1 8 8 8 5 HEAT-like repeat HEAT_2 PF13646.6 EXF75411.1 - 1.2e-16 60.9 11.1 0.0017 18.7 0.1 7.3 2 2 4 8 8 8 5 HEAT repeats HEAT PF02985.22 EXF75411.1 - 1.9e-15 55.6 15.1 0.11 12.8 0.2 8.8 10 0 0 10 10 9 5 HEAT repeat Adaptin_N PF01602.20 EXF75411.1 - 5.8e-10 38.4 9.7 3e-06 26.1 0.2 3.0 1 1 1 3 3 3 2 Adaptin N terminal region Arm_2 PF04826.13 EXF75411.1 - 2.2e-09 37.2 11.3 3.1e-06 26.8 3.5 3.4 2 1 1 3 3 3 2 Armadillo-like V-ATPase_H_N PF03224.14 EXF75411.1 - 3.2e-08 33.2 2.4 0.00029 20.2 1.1 3.1 2 1 0 3 3 3 2 V-ATPase subunit H KAP PF05804.12 EXF75411.1 - 2.5e-07 29.3 0.5 5.6e-07 28.1 0.5 1.6 1 0 0 1 1 1 1 Kinesin-associated protein (KAP) V-ATPase_H_C PF11698.8 EXF75411.1 - 0.00014 22.0 1.5 23 5.1 0.1 5.0 2 1 4 7 7 7 0 V-ATPase subunit H DUF5578 PF17741.1 EXF75411.1 - 0.00069 19.1 7.0 1.8 7.9 0.0 5.1 3 2 3 6 6 6 2 Family of unknown function (DUF5578) IFRD PF05004.13 EXF75411.1 - 0.0013 17.9 4.9 1.7 7.7 0.1 4.1 3 1 1 4 4 4 2 Interferon-related developmental regulator (IFRD) DUF3361 PF11841.8 EXF75411.1 - 0.0064 16.4 9.8 1.4 8.8 0.1 4.0 2 1 2 5 5 5 2 Domain of unknown function (DUF3361) HEAT_PBS PF03130.16 EXF75411.1 - 0.008 16.8 5.6 44 5.1 0.1 6.9 6 1 0 6 6 6 0 PBS lyase HEAT-like repeat Atx10homo_assoc PF09759.9 EXF75411.1 - 0.0096 15.9 5.9 5 7.2 0.1 4.7 4 1 1 5 5 5 1 Spinocerebellar ataxia type 10 protein domain Vac14_Fab1_bd PF12755.7 EXF75411.1 - 0.027 15.0 0.1 1.3 9.6 0.1 3.2 2 1 2 4 4 4 0 Vacuolar 14 Fab1-binding region UNC45-central PF11701.8 EXF75411.1 - 0.43 10.5 4.3 5.3 7.0 0.6 3.8 3 1 2 5 5 5 0 Myosin-binding striated muscle assembly central CBS PF00571.28 EXF75412.1 - 5.5e-26 90.8 7.4 4.8e-11 42.9 0.4 4.4 4 0 0 4 4 4 4 CBS domain RhoGAP PF00620.27 EXF75413.1 - 7.4e-07 29.1 0.0 1.4e-06 28.2 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain HAP1_N PF04849.13 EXF75413.1 - 0.022 14.0 0.7 0.035 13.3 0.7 1.2 1 0 0 1 1 1 0 HAP1 N-terminal conserved region DUF2285 PF10074.9 EXF75413.1 - 0.1 13.2 0.4 0.5 11.0 0.4 2.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2285) Fez1 PF06818.15 EXF75413.1 - 0.14 12.6 1.6 0.3 11.5 1.6 1.5 1 0 0 1 1 1 0 Fez1 PKcGMP_CC PF16808.5 EXF75413.1 - 0.17 11.8 1.4 0.48 10.3 1.4 1.7 1 0 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase GIT_CC PF16559.5 EXF75413.1 - 0.32 10.9 2.1 0.99 9.3 2.1 1.9 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor Rep_fac-A_3 PF08661.11 EXF75414.1 - 3.4e-20 72.3 0.0 3.7e-20 72.2 0.0 1.0 1 0 0 1 1 1 1 Replication factor A protein 3 Big_10 PF17964.1 EXF75414.1 - 0.13 12.2 0.0 0.16 11.9 0.0 1.1 1 0 0 1 1 1 0 Bacterial Ig domain bZIP_1 PF00170.21 EXF75415.1 - 1.1e-11 44.6 2.4 1.8e-11 44.0 2.4 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EXF75415.1 - 1.9e-06 27.9 2.4 3.6e-06 27.0 2.4 1.5 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 EXF75415.1 - 0.0017 18.8 3.2 0.0034 17.9 3.2 1.5 1 0 0 1 1 1 1 bZIP Maf transcription factor Phlebovirus_NSM PF07246.11 EXF75415.1 - 0.15 11.5 1.4 0.21 10.9 1.4 1.1 1 0 0 1 1 1 0 Phlebovirus nonstructural protein NS-M DUF4407 PF14362.6 EXF75415.1 - 0.17 11.2 0.1 0.22 10.8 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Ribosomal_L4 PF00573.22 EXF75416.1 - 1.1e-47 162.2 0.0 1.5e-47 161.8 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family DUF3604 PF12228.8 EXF75416.1 - 0.11 10.9 0.0 0.16 10.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3604) PBP PF01161.20 EXF75417.1 - 1.6e-08 35.0 0.0 3e-08 34.0 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein Sporozoite_P67 PF05642.11 EXF75419.1 - 0.51 8.4 5.0 0.54 8.3 5.0 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen PAN_4 PF14295.6 EXF75421.1 - 0.051 13.5 0.9 0.11 12.4 0.9 1.6 1 0 0 1 1 1 0 PAN domain MLANA PF14991.6 EXF75421.1 - 0.14 12.4 1.7 10 6.4 1.6 2.5 2 0 0 2 2 2 0 Protein melan-A Herpes_US9 PF06072.11 EXF75421.1 - 1.2 9.1 2.9 2.1 8.3 2.9 1.3 1 0 0 1 1 1 0 Alphaherpesvirus tegument protein US9 Glyco_transf_22 PF03901.17 EXF75422.1 - 1.4e-59 202.4 22.7 1.8e-59 202.0 22.7 1.0 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family PMT_2 PF13231.6 EXF75422.1 - 1.3 9.2 18.6 0.025 14.8 8.3 2.4 2 0 0 2 2 2 0 Dolichyl-phosphate-mannose-protein mannosyltransferase Methyltransf_23 PF13489.6 EXF75423.1 - 1.6e-19 70.3 0.0 3.3e-19 69.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF75423.1 - 4.2e-10 39.6 0.0 1.8e-09 37.6 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF75423.1 - 1.6e-09 38.4 0.0 4.4e-09 36.9 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF75423.1 - 7.4e-07 29.8 0.0 2.9e-06 27.9 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF75423.1 - 1.4e-06 28.8 0.0 3.4e-06 27.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.18 EXF75423.1 - 0.0016 17.7 0.0 0.003 16.9 0.0 1.4 1 0 0 1 1 1 1 O-methyltransferase domain FtsJ PF01728.19 EXF75423.1 - 0.0076 16.4 0.0 0.015 15.4 0.0 1.6 1 1 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_4 PF02390.17 EXF75423.1 - 0.012 15.1 0.0 0.027 13.9 0.0 1.6 1 0 0 1 1 1 0 Putative methyltransferase Ubie_methyltran PF01209.18 EXF75423.1 - 0.014 14.8 0.0 0.043 13.2 0.0 1.8 2 1 0 2 2 2 0 ubiE/COQ5 methyltransferase family PCMT PF01135.19 EXF75423.1 - 0.016 14.9 0.0 0.071 12.9 0.0 2.0 2 1 0 2 2 2 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.14 EXF75423.1 - 0.039 13.5 0.0 0.1 12.2 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase small domain Cupin_5 PF06172.11 EXF75424.1 - 4e-42 143.7 0.0 4.9e-42 143.4 0.0 1.1 1 0 0 1 1 1 1 Cupin superfamily (DUF985) TORC_M PF12885.7 EXF75424.1 - 0.048 13.6 0.4 0.11 12.4 0.4 1.6 1 0 0 1 1 1 0 Transducer of regulated CREB activity middle domain FAP PF07174.11 EXF75424.1 - 4.7 6.6 9.3 2.3 7.6 7.4 1.4 2 0 0 2 2 2 0 Fibronectin-attachment protein (FAP) Peptidase_M48 PF01435.18 EXF75425.1 - 1.4e-36 126.2 0.0 2.2e-36 125.5 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M48 Cyt-b5 PF00173.28 EXF75426.1 - 7.4e-22 77.3 0.1 8.2e-22 77.1 0.1 1.0 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain BRX PF08381.11 EXF75426.1 - 0.019 14.3 0.9 0.11 11.9 0.9 2.0 1 1 0 1 1 1 0 Transcription factor regulating root and shoot growth via Pin3 YqzH PF14164.6 EXF75426.1 - 0.13 12.4 0.3 1.1 9.3 0.0 2.2 2 1 0 2 2 2 0 YqzH-like protein Kinesin PF00225.23 EXF75427.1 - 4e-106 354.7 0.2 1.1e-105 353.2 0.0 1.8 2 0 0 2 2 2 1 Kinesin motor domain DUF3694 PF12473.8 EXF75427.1 - 1.5e-51 175.1 0.0 4.3e-51 173.6 0.0 1.9 1 0 0 1 1 1 1 Kinesin protein Kinesin_assoc PF16183.5 EXF75427.1 - 3.8e-37 128.2 11.9 3.4e-31 108.8 0.2 3.5 2 1 1 3 3 3 2 Kinesin-associated Microtub_bd PF16796.5 EXF75427.1 - 3.2e-21 75.8 0.0 8.2e-21 74.5 0.0 1.7 1 0 0 1 1 1 1 Microtubule binding KIF1B PF12423.8 EXF75427.1 - 1.2e-06 28.8 0.2 1.2e-06 28.8 0.2 2.7 2 0 0 2 2 2 1 Kinesin protein 1B PH PF00169.29 EXF75427.1 - 0.017 15.6 0.0 0.18 12.3 0.0 2.4 1 1 0 1 1 1 0 PH domain Succ_DH_flav_C PF02910.20 EXF75427.1 - 0.044 13.8 1.2 0.18 11.8 1.2 2.1 1 0 0 1 1 1 0 Fumarate reductase flavoprotein C-term Yop-YscD_cpl PF16697.5 EXF75427.1 - 0.08 13.3 0.0 0.42 11.0 0.0 2.2 1 0 0 1 1 1 0 Inner membrane component of T3SS, cytoplasmic domain Exonuc_VII_L PF02601.15 EXF75427.1 - 2 7.9 12.8 3.2 7.2 10.4 2.2 2 0 0 2 2 2 0 Exonuclease VII, large subunit UPF0242 PF06785.11 EXF75427.1 - 3.3 7.8 19.2 5 7.2 0.2 2.4 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF87 PF01935.17 EXF75427.1 - 7.1 6.7 9.1 44 4.1 0.1 3.1 3 0 0 3 3 3 0 Helicase HerA, central domain Uds1 PF15456.6 EXF75428.1 - 4.9e-33 114.1 6.2 1.8e-32 112.3 6.2 2.0 1 0 0 1 1 1 1 Up-regulated During Septation Stathmin PF00836.19 EXF75428.1 - 0.0065 16.4 0.3 0.029 14.3 0.3 2.1 1 0 0 1 1 1 1 Stathmin family TMF_TATA_bd PF12325.8 EXF75428.1 - 1.9 8.7 6.9 0.91 9.8 2.0 2.6 2 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding Spc7 PF08317.11 EXF75428.1 - 9.8 5.0 8.6 0.47 9.3 3.1 1.5 2 0 0 2 2 2 0 Spc7 kinetochore protein GATA PF00320.27 EXF75429.1 - 5.2e-13 48.4 1.5 1.6e-12 46.8 1.5 1.9 1 0 0 1 1 1 1 GATA zinc finger Bys1 PF04681.12 EXF75430.1 - 1.1e-08 35.1 0.2 1.3e-08 34.9 0.2 1.0 1 0 0 1 1 1 1 Blastomyces yeast-phase-specific protein HET PF06985.11 EXF75432.1 - 9e-26 91.0 0.0 1.7e-25 90.1 0.0 1.5 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) RasGAP PF00616.19 EXF75433.1 - 7.6e-60 202.2 1.8 1.5e-59 201.2 0.0 2.2 3 0 0 3 3 3 1 GTPase-activator protein for Ras-like GTPase RasGAP_C PF03836.15 EXF75433.1 - 1.7e-29 102.7 6.1 1.7e-29 102.7 6.1 2.4 2 0 0 2 2 2 1 RasGAP C-terminus CorA PF01544.18 EXF75434.1 - 8.8e-11 41.7 0.2 2.5e-10 40.1 0.0 1.8 2 0 0 2 2 2 1 CorA-like Mg2+ transporter protein DUF5315 PF17242.2 EXF75434.1 - 0.11 12.3 0.2 0.27 11.1 0.2 1.6 1 0 0 1 1 1 0 Disordered region of unknown function (DUF5315) Cep57_CLD_2 PF14197.6 EXF75434.1 - 2.7 8.1 5.9 2.2 8.5 1.1 2.3 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 ASF1_hist_chap PF04729.13 EXF75435.1 - 8.1e-73 243.5 0.0 1.1e-72 243.1 0.0 1.2 1 0 0 1 1 1 1 ASF1 like histone chaperone DMSP_lyase PF16867.5 EXF75435.1 - 0.17 11.5 0.0 0.3 10.7 0.0 1.3 1 0 0 1 1 1 0 Dimethlysulfonioproprionate lyase Suf PF05843.14 EXF75436.1 - 6e-77 259.5 0.0 6e-77 259.5 0.0 4.5 4 2 1 5 5 5 1 Suppressor of forked protein (Suf) TPR_14 PF13428.6 EXF75436.1 - 1.1e-06 28.9 4.0 0.0073 17.0 5.8 4.5 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 EXF75436.1 - 0.00025 21.6 0.3 0.014 16.0 1.3 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 EXF75436.1 - 0.0011 19.4 0.0 0.017 15.6 0.2 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.6 EXF75436.1 - 0.011 15.9 1.2 0.027 14.6 1.2 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat Peptidase_S80 PF07230.11 EXF75436.1 - 0.038 12.3 0.0 0.059 11.7 0.0 1.1 1 0 0 1 1 1 0 Bacteriophage T4-like capsid assembly protein (Gp20) TPR_17 PF13431.6 EXF75436.1 - 0.058 13.8 0.0 7.8 7.1 0.1 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat HrpJ PF07201.11 EXF75436.1 - 3.1 8.1 10.1 2.7 8.3 0.6 3.7 4 0 0 4 4 4 0 HrpJ-like domain Piwi PF02171.17 EXF75437.1 - 2.9e-78 263.2 0.0 4.2e-78 262.6 0.0 1.2 1 0 0 1 1 1 1 Piwi domain ArgoN PF16486.5 EXF75437.1 - 1.3e-21 77.7 0.0 4e-21 76.1 0.0 1.9 2 0 0 2 2 2 1 N-terminal domain of argonaute ArgoL1 PF08699.10 EXF75437.1 - 1.1e-15 57.1 0.7 6.4e-15 54.6 0.0 2.6 3 0 0 3 3 3 1 Argonaute linker 1 domain PAZ PF02170.22 EXF75437.1 - 2.4e-11 43.6 0.1 4.8e-11 42.6 0.1 1.5 1 0 0 1 1 1 1 PAZ domain ArgoL2 PF16488.5 EXF75437.1 - 3.2e-09 37.0 0.0 1.1e-08 35.3 0.0 2.0 1 0 0 1 1 1 1 Argonaute linker 2 domain ArgoMid PF16487.5 EXF75437.1 - 1.4e-07 31.7 0.0 4.8e-07 29.9 0.0 1.9 1 0 0 1 1 1 1 Mid domain of argonaute Reo_sigmaC PF04582.12 EXF75437.1 - 0.068 13.4 0.0 0.19 12.0 0.0 1.7 1 0 0 1 1 1 0 Reovirus sigma C capsid protein C-terminal domain NTP_transferase PF00483.23 EXF75438.1 - 3.5e-05 23.5 0.0 5.4e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 EXF75438.1 - 0.0069 16.8 0.0 0.013 15.8 0.0 1.5 1 0 0 1 1 1 1 MobA-like NTP transferase domain APH PF01636.23 EXF75438.1 - 0.0082 16.1 0.0 0.018 15.0 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Nuc_sug_transp PF04142.15 EXF75439.1 - 2.3e-28 99.3 18.5 1.3e-24 87.0 17.9 2.3 2 0 0 2 2 2 2 Nucleotide-sugar transporter PsbH PF00737.20 EXF75439.1 - 0.0098 15.6 0.1 0.031 14.0 0.1 1.9 1 0 0 1 1 1 1 Photosystem II 10 kDa phosphoprotein Glyco_hydro_32N PF00251.20 EXF75440.1 - 2.3e-60 204.7 4.3 3.7e-60 204.1 4.3 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 N-terminal domain Glyco_hydro_32C PF08244.12 EXF75440.1 - 3.6e-09 36.8 0.2 8.8e-09 35.5 0.1 1.7 2 0 0 2 2 2 1 Glycosyl hydrolases family 32 C terminal BNR PF02012.20 EXF75440.1 - 0.21 11.7 2.1 11 6.6 0.2 3.4 2 0 0 2 2 2 0 BNR/Asp-box repeat zf-C2H2 PF00096.26 EXF75442.1 - 3e-11 43.1 21.0 7.1e-06 26.2 2.1 3.6 3 1 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EXF75442.1 - 8.5e-06 26.0 9.3 0.013 15.9 0.3 4.5 4 0 0 4 4 4 1 Zinc-finger double domain zf-C2H2_jaz PF12171.8 EXF75442.1 - 9.5e-06 25.8 2.8 0.05 13.9 0.9 3.3 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 EXF75442.1 - 1e-05 26.0 16.9 0.011 16.5 0.3 3.7 3 1 0 3 3 3 2 C2H2-type zinc finger FOXP-CC PF16159.5 EXF75442.1 - 5.1e-05 23.8 4.5 0.66 10.6 0.0 3.1 2 1 1 3 3 3 2 FOXP coiled-coil domain zf-C2H2_6 PF13912.6 EXF75442.1 - 0.00023 21.1 4.7 0.0077 16.2 0.4 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_8 PF15909.5 EXF75442.1 - 0.0052 17.1 1.2 0.038 14.3 0.5 2.4 2 1 1 3 3 3 1 C2H2-type zinc ribbon zf_ZIC PF18366.1 EXF75442.1 - 0.42 10.7 5.6 3 8.0 0.2 3.1 3 0 0 3 3 3 0 Zic proteins zinc finger domain zf-H2C2_5 PF13909.6 EXF75442.1 - 0.56 10.0 8.5 2.1 8.2 0.4 3.5 3 0 0 3 3 3 0 C2H2-type zinc-finger domain zf-BED PF02892.15 EXF75442.1 - 1 9.4 5.4 7.5 6.7 0.4 2.6 2 1 0 2 2 2 0 BED zinc finger Sugar_tr PF00083.24 EXF75443.1 - 2.3e-44 152.0 19.7 6.1e-44 150.6 19.7 1.6 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF75443.1 - 1.7e-14 53.6 29.4 2.9e-14 52.7 28.6 1.8 2 1 0 2 2 2 1 Major Facilitator Superfamily Lgl_C PF08596.10 EXF75444.1 - 3.5e-111 371.7 0.0 5.7e-111 371.0 0.0 1.3 1 0 0 1 1 1 1 Lethal giant larvae(Lgl) like, C-terminal WD40 PF00400.32 EXF75444.1 - 2.2e-05 25.1 0.8 0.015 16.2 0.0 4.2 4 0 0 4 4 4 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EXF75444.1 - 9.7e-05 22.6 0.0 0.34 11.2 0.0 4.3 4 0 0 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Abhydrolase_1 PF00561.20 EXF75449.1 - 1.6e-12 47.6 0.2 6.5e-12 45.6 0.2 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EXF75449.1 - 1.8e-06 28.7 0.9 2.4e-06 28.3 0.9 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EXF75449.1 - 9.5e-05 21.8 0.0 0.038 13.3 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 DUF2573 PF10835.8 EXF75450.1 - 0.036 14.4 0.0 0.063 13.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2573) FAD_binding_3 PF01494.19 EXF75452.1 - 1.4e-82 277.8 0.0 1.7e-82 277.5 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Phe_hydrox_dim PF07976.12 EXF75452.1 - 6e-48 163.0 0.0 1.1e-47 162.2 0.0 1.4 1 0 0 1 1 1 1 Phenol hydroxylase, C-terminal dimerisation domain DAO PF01266.24 EXF75452.1 - 8.6e-05 22.3 0.0 0.0017 18.0 0.0 2.7 3 0 0 3 3 3 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EXF75452.1 - 8.9e-05 21.9 0.0 0.00019 20.8 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EXF75452.1 - 0.0002 20.6 0.2 0.0003 20.0 0.2 1.2 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 EXF75452.1 - 0.00022 20.1 0.0 0.00033 19.5 0.0 1.2 1 0 0 1 1 1 1 HI0933-like protein NAD_binding_8 PF13450.6 EXF75452.1 - 0.0026 18.0 0.1 0.0071 16.6 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 EXF75452.1 - 0.003 16.7 0.2 0.0082 15.3 0.0 1.7 2 0 0 2 2 2 1 Glucose inhibited division protein A Lycopene_cycl PF05834.12 EXF75452.1 - 0.0045 16.1 0.0 0.0065 15.6 0.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein Thi4 PF01946.17 EXF75452.1 - 0.0062 15.8 0.0 0.018 14.3 0.0 1.7 2 0 0 2 2 2 1 Thi4 family Pyr_redox PF00070.27 EXF75452.1 - 0.0073 16.9 0.0 0.016 15.7 0.0 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 EXF75452.1 - 0.013 14.9 0.0 0.021 14.1 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox_3 PF13738.6 EXF75452.1 - 0.015 14.6 0.0 0.023 14.0 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EXF75452.1 - 0.016 14.5 0.1 0.029 13.7 0.1 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase SE PF08491.10 EXF75452.1 - 0.25 10.3 0.0 3.1 6.8 0.0 2.1 2 0 0 2 2 2 0 Squalene epoxidase CLP1_P PF16575.5 EXF75453.1 - 8.9e-30 103.9 0.0 1.3e-29 103.3 0.0 1.3 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop RNA_polI_A34 PF08208.11 EXF75454.1 - 3.8e-46 157.8 8.6 3.8e-46 157.8 8.6 6.5 3 2 0 3 3 3 1 DNA-directed RNA polymerase I subunit RPA34.5 FUSC-like PF12805.7 EXF75456.1 - 1.5 7.8 4.3 2.5 7.1 1.8 2.1 1 1 1 2 2 2 0 FUSC-like inner membrane protein yccS SDA1 PF05285.12 EXF75456.1 - 6.9 6.0 10.5 10 5.4 10.5 1.1 1 0 0 1 1 1 0 SDA1 PAP2_3 PF14378.6 EXF75457.1 - 4.9e-25 88.3 11.1 4.9e-25 88.3 11.1 1.6 2 0 0 2 2 2 1 PAP2 superfamily PAP2 PF01569.21 EXF75457.1 - 8.5e-10 38.5 5.6 8.5e-10 38.5 5.6 2.2 2 1 0 2 2 2 1 PAP2 superfamily IHHNV_capsid PF16530.5 EXF75458.1 - 0.089 11.9 0.5 0.097 11.8 0.5 1.1 1 0 0 1 1 1 0 Infectious hypodermal and haematopoietic necrosis virus, capsid Peptidase_M3 PF01432.20 EXF75459.1 - 4.2e-106 355.9 0.0 8.5e-55 186.8 0.0 2.1 2 0 0 2 2 2 2 Peptidase family M3 HNH PF01844.23 EXF75461.1 - 0.0013 18.9 1.8 0.0028 17.8 1.8 1.6 1 0 0 1 1 1 1 HNH endonuclease Hydrolase_like PF13242.6 EXF75462.1 - 8.6e-05 22.5 0.0 0.00014 21.8 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 EXF75462.1 - 0.00069 20.0 0.0 0.0029 17.9 0.0 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EXF75462.1 - 0.0082 16.2 0.0 0.11 12.6 0.0 2.2 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase D5_N PF08706.11 EXF75462.1 - 0.0089 16.3 0.0 0.014 15.7 0.0 1.3 1 0 0 1 1 1 1 D5 N terminal like AAA_5 PF07728.14 EXF75462.1 - 0.052 13.6 0.0 0.24 11.4 0.1 1.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) UCH PF00443.29 EXF75463.1 - 2.9e-54 184.3 0.0 1.1e-53 182.4 0.0 2.0 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EXF75463.1 - 1.5e-25 90.5 2.3 1.6e-19 70.7 0.0 2.6 3 0 0 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase Mitofilin PF09731.9 EXF75463.1 - 0.47 9.2 24.4 0.86 8.4 24.4 1.3 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Macoilin PF09726.9 EXF75463.1 - 2.4 6.6 14.6 3.8 5.9 14.6 1.2 1 0 0 1 1 1 0 Macoilin family Peptidase_C98 PF15499.6 EXF75463.1 - 5.9 6.3 12.2 0.3 10.5 0.9 3.2 4 0 0 4 4 4 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase Glyco_transf_22 PF03901.17 EXF75464.1 - 1.2e-41 143.3 11.4 1.5e-41 143.0 11.4 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family PP2C PF00481.21 EXF75465.1 - 3.8e-59 200.4 0.0 1.3e-58 198.6 0.0 2.0 2 0 0 2 2 2 1 Protein phosphatase 2C LRR_8 PF13855.6 EXF75465.1 - 1.9e-34 117.2 66.1 4.1e-10 39.3 0.8 10.5 4 3 8 12 12 12 10 Leucine rich repeat LRR_4 PF12799.7 EXF75465.1 - 1e-31 108.4 74.8 0.00016 22.0 0.1 12.9 8 1 5 14 14 14 11 Leucine Rich repeats (2 copies) Guanylate_cyc PF00211.20 EXF75465.1 - 5e-31 107.7 0.1 3.1e-30 105.2 0.0 2.0 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain Ad_cyc_g-alpha PF08509.11 EXF75465.1 - 5.6e-15 54.8 0.9 2.3e-14 52.8 0.9 2.1 1 0 0 1 1 1 1 Adenylate cyclase G-alpha binding domain LRR_1 PF00560.33 EXF75465.1 - 1.4e-05 25.0 54.9 12 6.9 0.1 16.9 17 2 0 17 17 17 3 Leucine Rich Repeat LRR_9 PF14580.6 EXF75465.1 - 0.0012 18.4 21.8 0.047 13.2 2.7 4.5 2 1 1 4 4 4 3 Leucine-rich repeat LRR_6 PF13516.6 EXF75465.1 - 0.81 9.9 42.9 3.3 8.0 0.3 12.0 13 0 0 13 13 13 0 Leucine Rich repeat Aldo_ket_red PF00248.21 EXF75466.1 - 1.5e-71 241.0 0.0 1.7e-71 240.8 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Alpha-amylase PF00128.24 EXF75467.1 - 9.1e-115 383.8 0.4 1.3e-114 383.3 0.4 1.2 1 0 0 1 1 1 1 Alpha amylase, catalytic domain Malt_amylase_C PF16657.5 EXF75467.1 - 3.2e-05 23.9 0.0 6.6e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 Maltogenic Amylase, C-terminal domain Alpha-amylase_C PF02806.18 EXF75467.1 - 0.029 14.8 0.0 0.084 13.4 0.0 1.8 1 0 0 1 1 1 0 Alpha amylase, C-terminal all-beta domain hDGE_amylase PF14701.6 EXF75467.1 - 0.045 12.9 0.0 0.079 12.0 0.0 1.3 1 0 0 1 1 1 0 Glycogen debranching enzyme, glucanotransferase domain Fungal_trans PF04082.18 EXF75468.1 - 5.3e-09 35.5 0.0 8.6e-09 34.8 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF75468.1 - 4.3e-08 33.1 5.6 7.1e-08 32.4 5.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.16 EXF75469.1 - 7.1e-22 77.8 22.0 9.6e-22 77.4 22.0 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily TauD PF02668.16 EXF75470.1 - 3.7e-55 187.6 0.0 5.8e-55 187.0 0.0 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family RTC4 PF14474.6 EXF75471.1 - 8.7e-32 109.8 0.0 1.9e-31 108.7 0.0 1.6 1 0 0 1 1 1 1 RTC4-like domain Dynamitin PF04912.14 EXF75472.1 - 1.9e-115 386.3 3.0 2.1e-115 386.1 3.0 1.0 1 0 0 1 1 1 1 Dynamitin FH2 PF02181.23 EXF75472.1 - 0.00027 20.2 3.5 0.27 10.3 0.0 3.0 3 0 0 3 3 3 2 Formin Homology 2 Domain ATF7IP_BD PF16788.5 EXF75472.1 - 0.0042 17.2 0.1 0.01 15.9 0.1 1.6 1 0 0 1 1 1 1 ATF-interacting protein binding domain Spore_III_AB PF09548.10 EXF75472.1 - 0.0069 16.5 4.3 0.043 13.9 0.5 3.2 3 1 0 3 3 3 1 Stage III sporulation protein AB (spore_III_AB) Phage_GP20 PF06810.11 EXF75472.1 - 0.012 15.5 1.3 0.012 15.5 1.3 3.3 3 0 0 3 3 3 0 Phage minor structural protein GP20 Fib_alpha PF08702.10 EXF75472.1 - 0.012 15.8 1.6 16 5.6 0.0 3.4 3 0 0 3 3 3 0 Fibrinogen alpha/beta chain family IFT57 PF10498.9 EXF75472.1 - 0.013 14.5 4.1 0.13 11.2 0.0 2.9 3 0 0 3 3 3 0 Intra-flagellar transport protein 57 RPN7 PF10602.9 EXF75472.1 - 0.039 13.7 2.0 0.05 13.3 0.5 1.9 2 0 0 2 2 2 0 26S proteasome subunit RPN7 SKA1 PF07160.12 EXF75472.1 - 0.053 13.4 1.9 8.3 6.2 0.0 3.1 3 0 0 3 3 3 0 Spindle and kinetochore-associated protein 1 BLOC1_2 PF10046.9 EXF75472.1 - 0.068 13.5 6.9 17 5.8 0.9 4.0 3 2 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 MIOX PF05153.15 EXF75472.1 - 0.085 12.4 0.1 0.14 11.7 0.1 1.2 1 0 0 1 1 1 0 Myo-inositol oxygenase DUF724 PF05266.14 EXF75472.1 - 0.089 12.6 5.0 1.2 8.9 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF724) Allexi_40kDa PF05549.11 EXF75472.1 - 0.12 11.9 2.1 1.8 8.0 0.3 2.6 3 0 0 3 3 3 0 Allexivirus 40kDa protein Laminin_II PF06009.12 EXF75472.1 - 0.13 12.3 7.7 1.3 9.0 0.1 3.9 3 1 1 4 4 4 0 Laminin Domain II Matrilin_ccoil PF10393.9 EXF75472.1 - 0.19 11.6 1.6 10 6.1 0.1 2.7 2 0 0 2 2 2 0 Trimeric coiled-coil oligomerisation domain of matrilin WXG100 PF06013.12 EXF75472.1 - 0.23 11.7 5.9 7.1 6.9 0.0 3.5 3 0 0 3 3 3 0 Proteins of 100 residues with WXG KxDL PF10241.9 EXF75472.1 - 0.27 11.6 3.2 13 6.1 0.1 3.5 3 1 0 3 3 3 0 Uncharacterized conserved protein Halogen_Hydrol PF10112.9 EXF75472.1 - 0.29 11.1 1.8 14 5.6 0.1 3.0 3 0 0 3 3 3 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein Cytochrom_B562 PF07361.11 EXF75472.1 - 0.49 11.1 9.2 0.29 11.8 0.5 3.3 3 1 0 3 3 3 0 Cytochrome b562 SOGA PF11365.8 EXF75472.1 - 0.61 11.2 6.9 1.5 10.0 0.1 3.1 3 0 0 3 3 3 0 Protein SOGA ZapB PF06005.12 EXF75472.1 - 0.69 10.4 9.5 0.75 10.3 1.2 3.3 3 0 0 3 3 3 0 Cell division protein ZapB DUF1192 PF06698.11 EXF75472.1 - 0.76 9.9 7.2 2.2 8.4 1.6 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1192) CENP-F_leu_zip PF10473.9 EXF75472.1 - 0.83 9.7 10.7 2.3 8.3 1.5 3.3 3 0 0 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DHR10 PF18595.1 EXF75472.1 - 1.2 9.2 18.6 13 5.8 0.4 4.4 3 1 1 4 4 4 0 Designed helical repeat protein 10 domain GrpE PF01025.19 EXF75472.1 - 1.3 8.7 5.2 1.3 8.7 1.1 2.7 3 0 0 3 3 3 0 GrpE ATP-synt_E PF05680.12 EXF75472.1 - 1.6 9.1 6.5 0.23 11.8 0.7 2.4 3 0 0 3 3 2 0 ATP synthase E chain Fzo_mitofusin PF04799.13 EXF75472.1 - 1.6 8.2 4.4 25 4.4 0.1 3.1 3 0 0 3 3 3 0 fzo-like conserved region DUF2203 PF09969.9 EXF75472.1 - 1.9 9.2 8.9 29 5.4 0.4 3.5 3 1 1 4 4 3 0 Uncharacterized conserved protein (DUF2203) Baculo_PEP_C PF04513.12 EXF75472.1 - 2.2 8.3 5.7 9.6 6.2 1.4 3.0 2 2 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Laminin_I PF06008.14 EXF75472.1 - 3.1 7.4 11.2 2.8 7.6 0.6 3.0 2 1 0 2 2 2 0 Laminin Domain I Prefoldin_2 PF01920.20 EXF75472.1 - 3.2 7.8 11.8 15 5.6 0.0 4.2 3 1 1 4 4 4 0 Prefoldin subunit FAM184 PF15665.5 EXF75472.1 - 4.3 7.1 9.4 1.1 9.0 1.8 3.0 3 1 0 3 3 3 0 Family with sequence similarity 184, A and B Syntaxin-6_N PF09177.11 EXF75472.1 - 4.7 7.8 6.6 25 5.5 0.6 3.6 3 1 0 3 3 3 0 Syntaxin 6, N-terminal RmuC PF02646.16 EXF75472.1 - 7.1 5.7 7.3 11 5.0 0.1 3.0 3 0 0 3 3 3 0 RmuC family FlgN PF05130.12 EXF75472.1 - 7.7 7.0 16.1 0.091 13.3 3.1 2.9 2 1 1 3 3 3 0 FlgN protein Wtap PF17098.5 EXF75472.1 - 8.9 6.2 11.6 28 4.6 1.0 3.1 1 1 1 3 3 3 0 WTAP/Mum2p family Ribosomal_S28e PF01200.18 EXF75473.1 - 1.4e-31 108.3 2.0 1.5e-31 108.1 2.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S28e ThiS PF02597.20 EXF75474.1 - 8.9e-10 39.1 0.0 1.2e-09 38.7 0.0 1.2 1 0 0 1 1 1 1 ThiS family PSI PF01437.25 EXF75475.1 - 7.1e-05 23.3 8.3 0.00016 22.2 8.3 1.6 1 0 0 1 1 1 1 Plexin repeat Rab5ip PF07019.12 EXF75475.1 - 0.012 16.2 0.0 0.019 15.5 0.0 1.2 1 0 0 1 1 1 0 Rab5-interacting protein (Rab5ip) Sugar_tr PF00083.24 EXF75476.1 - 1.7e-83 281.0 18.8 2.1e-83 280.7 18.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF75476.1 - 2.8e-26 92.3 34.5 7.6e-21 74.4 8.4 2.1 1 1 0 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EXF75476.1 - 0.00048 18.7 2.4 0.0036 15.8 0.7 2.2 2 0 0 2 2 2 2 Fungal trichothecene efflux pump (TRI12) IBR PF01485.21 EXF75477.1 - 6.1e-06 26.4 22.8 3.1e-05 24.1 11.6 3.4 3 0 0 3 3 3 2 IBR domain, a half RING-finger domain Mo-nitro_C PF06967.11 EXF75477.1 - 0.11 12.5 1.3 1.3 9.0 1.5 2.4 2 0 0 2 2 2 0 Mo-dependent nitrogenase C-terminus FAA_hydrolase PF01557.18 EXF75478.1 - 3.9e-62 209.8 0.0 4.8e-62 209.5 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family SNF2_N PF00176.23 EXF75480.1 - 2.3e-50 171.3 0.0 4e-50 170.5 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EXF75480.1 - 1.2e-17 64.2 0.2 3.4e-17 62.8 0.2 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 EXF75480.1 - 5.4e-05 22.5 1.3 8.9e-05 21.8 0.2 1.8 1 1 1 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase UBA PF00627.31 EXF75480.1 - 0.0016 18.3 0.2 0.004 17.0 0.2 1.7 1 0 0 1 1 1 1 UBA/TS-N domain HBS1_N PF08938.10 EXF75480.1 - 0.046 14.0 4.6 0.046 14.0 0.1 2.9 2 0 0 2 2 2 0 HBS1 N-terminus CUE PF02845.16 EXF75480.1 - 0.1 12.3 0.1 0.24 11.1 0.1 1.7 1 0 0 1 1 1 0 CUE domain VMA21 PF09446.10 EXF75481.1 - 1.9e-16 59.9 8.3 2.8e-16 59.4 8.3 1.3 1 0 0 1 1 1 1 VMA21-like domain DUF2406 PF10295.9 EXF75482.1 - 2.7e-26 92.0 0.5 2.7e-26 92.0 0.5 2.2 2 0 0 2 2 2 1 Uncharacterised protein (DUF2406) KIAA1328 PF15369.6 EXF75482.1 - 0.33 10.7 4.1 0.6 9.9 4.1 1.6 1 0 0 1 1 1 0 Uncharacterised protein KIAA1328 zf-C2HE PF16278.5 EXF75483.1 - 0.2 12.2 4.6 7.2 7.1 0.5 2.9 2 1 1 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger CorA PF01544.18 EXF75484.1 - 2.9e-41 141.7 0.4 1.4e-40 139.5 0.4 1.9 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein Osmo_CC PF08946.10 EXF75484.1 - 0.035 14.4 0.7 0.087 13.1 0.7 1.6 1 0 0 1 1 1 0 Osmosensory transporter coiled coil CBF PF03914.17 EXF75485.1 - 1.5e-32 113.0 0.4 1.5e-32 113.0 0.4 2.4 2 2 2 4 4 4 1 CBF/Mak21 family Mt_ATP-synt_B PF05405.14 EXF75486.1 - 1.3e-53 181.0 2.7 1.6e-53 180.6 2.7 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) tRNA_anti-codon PF01336.25 EXF75486.1 - 0.093 12.7 0.0 0.19 11.8 0.0 1.4 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain MSC PF09402.10 EXF75487.1 - 1.6e-115 386.2 0.0 2.1e-115 385.8 0.0 1.1 1 0 0 1 1 1 1 Man1-Src1p-C-terminal domain HeH PF12949.7 EXF75487.1 - 3.6e-18 65.0 0.1 7.1e-18 64.0 0.1 1.5 1 0 0 1 1 1 1 HeH/LEM domain Thymopoietin PF08198.11 EXF75487.1 - 0.0042 16.7 0.0 0.0091 15.6 0.0 1.5 1 0 0 1 1 1 1 Thymopoietin protein FAD_binding_3 PF01494.19 EXF75488.1 - 6.3e-25 88.2 0.0 2.2e-23 83.1 0.0 2.1 1 1 0 1 1 1 1 FAD binding domain Lycopene_cycl PF05834.12 EXF75488.1 - 6.2e-05 22.2 0.1 0.0089 15.1 0.0 2.6 3 0 0 3 3 3 1 Lycopene cyclase protein DAO PF01266.24 EXF75488.1 - 0.00014 21.5 0.0 0.56 9.7 0.0 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase SE PF08491.10 EXF75488.1 - 0.0004 19.5 0.0 0.00062 18.9 0.0 1.2 1 0 0 1 1 1 1 Squalene epoxidase Pyr_redox_2 PF07992.14 EXF75488.1 - 0.0036 16.6 0.0 0.023 13.9 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EXF75488.1 - 0.0047 16.9 0.0 0.01 15.8 0.0 1.5 1 0 0 1 1 1 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 EXF75488.1 - 0.061 13.6 0.0 0.17 12.1 0.0 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 EXF75488.1 - 0.074 12.2 0.1 0.18 10.9 0.0 1.7 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) Thi4 PF01946.17 EXF75488.1 - 0.094 11.9 0.0 0.67 9.1 0.0 2.0 2 0 0 2 2 2 0 Thi4 family E1-N PF14463.6 EXF75488.1 - 0.12 12.2 0.2 0.39 10.5 0.2 1.8 2 0 0 2 2 2 0 E1 N-terminal domain Trp_halogenase PF04820.14 EXF75488.1 - 0.13 11.1 0.0 1.6 7.4 0.0 2.2 2 0 0 2 2 2 0 Tryptophan halogenase PLAC9 PF15205.6 EXF75488.1 - 0.24 11.8 0.5 35 4.9 0.0 3.8 4 0 0 4 4 4 0 Placenta-specific protein 9 Complex1_49kDa PF00346.19 EXF75489.1 - 1.4e-120 401.5 0.0 2e-120 401.0 0.0 1.2 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 49 Kd subunit NiFeSe_Hases PF00374.19 EXF75489.1 - 0.04 12.8 0.0 0.077 11.9 0.0 1.4 1 1 0 1 1 1 0 Nickel-dependent hydrogenase SNase PF00565.17 EXF75490.1 - 2.2e-21 76.3 0.1 3.3e-21 75.8 0.1 1.3 1 0 0 1 1 1 1 Staphylococcal nuclease homologue Pkinase PF00069.25 EXF75491.1 - 2.3e-54 184.5 0.0 3.2e-54 184.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF75491.1 - 4.1e-41 141.0 0.0 6.4e-41 140.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EXF75491.1 - 0.0021 17.4 0.0 0.026 13.8 0.0 2.1 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 EXF75491.1 - 0.019 14.9 0.0 0.15 12.0 0.0 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EXF75491.1 - 0.025 13.4 0.0 0.1 11.4 0.0 1.9 2 0 0 2 2 2 0 Fungal protein kinase Haspin_kinase PF12330.8 EXF75491.1 - 0.089 11.7 0.0 1.4 7.7 0.0 2.1 2 0 0 2 2 2 0 Haspin like kinase domain Telomere_reg-2 PF10193.9 EXF75492.1 - 5.1e-37 126.6 0.2 3.4e-36 124.0 0.0 2.6 3 0 0 3 3 3 1 Telomere length regulation protein ThiF PF00899.21 EXF75493.1 - 9.9e-64 215.0 0.1 1.4e-63 214.5 0.1 1.2 1 0 0 1 1 1 1 ThiF family E2_bind PF08825.10 EXF75493.1 - 1.4e-29 102.1 0.1 2.3e-29 101.3 0.1 1.4 1 0 0 1 1 1 1 E2 binding domain Shikimate_DH PF01488.20 EXF75493.1 - 0.00015 21.9 0.5 0.00035 20.6 0.0 1.8 2 1 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase UAE_UbL PF14732.6 EXF75493.1 - 0.001 19.6 0.1 0.023 15.3 0.0 2.4 2 0 0 2 2 2 1 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain Sacchrp_dh_NADP PF03435.18 EXF75493.1 - 0.042 14.1 0.1 0.11 12.7 0.1 1.8 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain NAD_binding_7 PF13241.6 EXF75493.1 - 0.053 14.0 0.1 0.13 12.7 0.1 1.7 1 0 0 1 1 1 0 Putative NAD(P)-binding Pyr_redox PF00070.27 EXF75493.1 - 0.12 12.9 0.0 0.27 11.8 0.0 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase UBA_e1_thiolCys PF10585.9 EXF75493.1 - 0.33 10.8 2.9 8.7 6.2 0.0 2.4 1 1 1 2 2 2 0 Ubiquitin-activating enzyme active site RNA_pol_A_bac PF01000.26 EXF75494.1 - 1.5e-28 99.4 0.0 3e-28 98.4 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 EXF75494.1 - 1.6e-19 69.1 0.0 2.7e-19 68.4 0.0 1.4 1 1 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain EKLF_TAD2 PF16833.5 EXF75494.1 - 0.41 10.7 0.1 0.41 10.7 0.1 1.7 2 0 0 2 2 2 0 Erythroid krueppel-like transcription factor, transactivation 2 BTB_2 PF02214.22 EXF75495.1 - 0.00043 20.6 0.3 0.0011 19.3 0.1 1.8 2 0 0 2 2 2 1 BTB/POZ domain SpoVAD PF07451.11 EXF75495.1 - 0.21 10.2 0.8 0.37 9.4 0.1 1.6 2 0 0 2 2 2 0 Stage V sporulation protein AD (SpoVAD) OTT_1508_deam PF14441.6 EXF75496.1 - 5.2e-18 64.8 0.8 1.1e-17 63.7 0.8 1.6 1 0 0 1 1 1 1 OTT_1508-like deaminase CDC45 PF02724.14 EXF75496.1 - 4.4 5.5 8.4 7 4.8 8.4 1.3 1 0 0 1 1 1 0 CDC45-like protein Herpes_UL1 PF05259.11 EXF75497.1 - 0.045 13.8 0.0 0.08 13.0 0.0 1.4 1 0 0 1 1 1 0 Herpesvirus glycoprotein L RE_SinI PF09570.10 EXF75497.1 - 0.12 11.6 0.1 0.24 10.6 0.1 1.4 1 0 0 1 1 1 0 SinI restriction endonuclease AAA PF00004.29 EXF75498.1 - 3.4e-54 182.8 0.0 3e-43 147.4 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) PEX-1N PF09262.11 EXF75498.1 - 2.6e-28 98.3 0.3 7.5e-28 96.8 0.3 1.9 1 0 0 1 1 1 1 Peroxisome biogenesis factor 1, N-terminal AAA_lid_3 PF17862.1 EXF75498.1 - 8e-12 44.8 1.5 8.9e-09 35.0 0.0 3.2 3 0 0 3 3 3 2 AAA+ lid domain AAA_16 PF13191.6 EXF75498.1 - 1.6e-11 44.9 3.6 2.1e-05 25.0 0.1 4.2 2 2 2 4 4 4 2 AAA ATPase domain NACHT PF05729.12 EXF75498.1 - 5e-08 33.0 0.4 5.3e-05 23.2 0.0 3.3 3 0 0 3 3 3 1 NACHT domain RuvB_N PF05496.12 EXF75498.1 - 3.3e-06 26.9 0.0 0.014 15.1 0.0 2.5 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain TsaE PF02367.17 EXF75498.1 - 7.9e-06 25.9 0.0 0.017 15.1 0.0 2.4 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_18 PF13238.6 EXF75498.1 - 7.9e-06 26.5 0.1 0.023 15.2 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.6 EXF75498.1 - 9.8e-06 25.8 0.0 0.26 11.5 0.0 2.7 2 0 0 2 2 2 2 AAA domain TIP49 PF06068.13 EXF75498.1 - 1.2e-05 24.7 0.0 0.024 13.9 0.0 2.2 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_22 PF13401.6 EXF75498.1 - 2.5e-05 24.5 1.6 0.19 12.0 0.1 3.7 2 2 1 3 3 3 1 AAA domain AAA_2 PF07724.14 EXF75498.1 - 3.3e-05 24.1 0.0 0.26 11.4 0.0 2.5 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 EXF75498.1 - 0.00014 21.9 0.2 0.57 10.2 0.0 2.9 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 EXF75498.1 - 0.00019 21.5 0.0 0.3 11.1 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.6 EXF75498.1 - 0.00027 20.6 0.9 1.3 8.6 0.1 3.4 2 1 1 3 3 3 2 AAA domain AAA_7 PF12775.7 EXF75498.1 - 0.0003 20.3 0.0 0.012 15.1 0.0 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region PEX-2N PF09263.10 EXF75498.1 - 0.00091 19.5 0.9 0.5 10.7 0.1 3.2 3 1 0 3 3 2 1 Peroxisome biogenesis factor 1, N-terminal IstB_IS21 PF01695.17 EXF75498.1 - 0.0011 18.7 0.1 0.96 9.1 0.0 2.4 2 0 0 2 2 2 2 IstB-like ATP binding protein RNA_helicase PF00910.22 EXF75498.1 - 0.0022 18.4 0.0 3.5 8.1 0.0 2.7 2 0 0 2 2 2 2 RNA helicase SKI PF01202.22 EXF75498.1 - 0.0026 17.9 0.1 0.43 10.7 0.0 2.5 2 0 0 2 2 2 1 Shikimate kinase Zeta_toxin PF06414.12 EXF75498.1 - 0.0029 16.9 2.4 0.55 9.5 0.0 3.1 3 0 0 3 3 3 1 Zeta toxin Cytidylate_kin2 PF13189.6 EXF75498.1 - 0.005 17.0 0.1 4.9 7.3 0.0 2.5 2 0 0 2 2 2 1 Cytidylate kinase-like family Mg_chelatase PF01078.21 EXF75498.1 - 0.0058 16.0 0.7 0.79 9.1 0.1 2.7 3 0 0 3 3 2 1 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 EXF75498.1 - 0.0065 16.7 0.1 1.6 9.0 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.6 EXF75498.1 - 0.0074 16.7 0.4 2.5 8.5 0.1 2.7 2 0 0 2 2 2 1 AAA domain Sigma54_activat PF00158.26 EXF75498.1 - 0.0084 15.8 0.1 0.93 9.2 0.0 3.0 3 0 0 3 3 3 1 Sigma-54 interaction domain Sigma54_activ_2 PF14532.6 EXF75498.1 - 0.019 15.1 0.0 1.3 9.1 0.0 2.6 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_29 PF13555.6 EXF75498.1 - 0.041 13.6 0.0 0.9 9.3 0.1 2.7 2 0 0 2 2 2 0 P-loop containing region of AAA domain Rad17 PF03215.15 EXF75498.1 - 0.041 13.8 0.0 4.5 7.1 0.0 2.3 2 0 0 2 2 2 0 Rad17 P-loop domain Viral_helicase1 PF01443.18 EXF75498.1 - 0.047 13.4 0.0 4.3 7.0 0.0 2.5 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase ATPase PF06745.13 EXF75498.1 - 0.051 12.9 0.0 13 5.1 0.0 2.4 2 0 0 2 2 2 0 KaiC ABC_tran PF00005.27 EXF75498.1 - 0.052 14.1 0.0 26 5.3 0.0 2.9 2 0 0 2 2 2 0 ABC transporter DUF2075 PF09848.9 EXF75498.1 - 0.094 11.9 0.0 9 5.4 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_3 PF07726.11 EXF75498.1 - 0.17 11.7 0.0 8.3 6.3 0.0 2.3 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) APS_kinase PF01583.20 EXF75498.1 - 0.17 11.7 0.2 1.1 9.2 0.0 2.3 2 0 0 2 2 2 0 Adenylylsulphate kinase MCM PF00493.23 EXF75499.1 - 4.2e-104 346.5 0.0 7.1e-104 345.8 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EXF75499.1 - 4.1e-28 97.8 0.7 7e-28 97.0 0.7 1.3 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EXF75499.1 - 6.2e-21 74.6 0.6 1.4e-20 73.5 0.6 1.6 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 EXF75499.1 - 4.3e-18 65.8 0.3 1.2e-17 64.4 0.3 1.8 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 EXF75499.1 - 1.2e-07 31.4 0.0 1.4e-05 24.5 0.0 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EXF75499.1 - 4.2e-06 26.8 0.0 1.4e-05 25.1 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_lid_2 PF17863.1 EXF75499.1 - 0.001 18.9 0.3 0.0034 17.2 0.3 1.9 1 0 0 1 1 1 1 AAA lid domain AAA_3 PF07726.11 EXF75499.1 - 0.015 15.2 0.0 0.05 13.5 0.0 1.9 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RecX PF02631.16 EXF75499.1 - 0.045 14.2 0.6 0.64 10.5 0.1 2.4 2 0 0 2 2 2 0 RecX family Mg_chelatase_C PF13335.6 EXF75499.1 - 0.048 14.3 2.0 0.17 12.5 0.4 2.7 2 1 1 3 3 3 0 Magnesium chelatase, subunit ChlI C-terminal Sigma54_activat PF00158.26 EXF75499.1 - 0.16 11.7 0.0 0.96 9.1 0.0 2.1 2 0 0 2 2 2 0 Sigma-54 interaction domain EcoR124_C PF12008.8 EXF75499.1 - 0.17 11.5 0.9 0.37 10.4 0.9 1.6 1 0 0 1 1 1 0 Type I restriction and modification enzyme - subunit R C terminal DAP3 PF10236.9 EXF75500.1 - 1e-91 307.3 0.0 1.5e-91 306.9 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal death-associated protein 3 RRS1 PF04939.12 EXF75501.1 - 1.5e-58 197.3 6.8 1.7e-58 197.1 6.8 1.0 1 0 0 1 1 1 1 Ribosome biogenesis regulatory protein (RRS1) U1snRNP70_N PF12220.8 EXF75501.1 - 1.5 9.5 9.1 7.5 7.3 4.7 2.4 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal RhoGAP PF00620.27 EXF75502.1 - 3.6e-28 98.3 0.0 7.4e-28 97.3 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain Prenyltrans PF00432.21 EXF75503.1 - 5.6e-54 179.5 11.1 1.3e-11 44.0 0.0 6.1 6 0 0 6 6 6 6 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_N PF13249.6 EXF75503.1 - 0.0012 18.0 0.0 0.22 10.6 0.0 3.1 2 1 2 4 4 4 2 Squalene-hopene cyclase N-terminal domain zf-C2H2_2 PF12756.7 EXF75504.1 - 0.045 14.1 0.0 0.11 12.8 0.0 1.7 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) MutS_V PF00488.21 EXF75505.1 - 8.9e-70 234.6 0.1 1.6e-69 233.7 0.1 1.4 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 EXF75505.1 - 2.5e-34 119.2 1.5 2.5e-34 119.2 1.5 2.0 2 0 0 2 2 2 1 MutS domain III MutS_I PF01624.20 EXF75505.1 - 9.3e-29 100.0 0.0 2e-28 98.9 0.0 1.6 1 0 0 1 1 1 1 MutS domain I MutS_II PF05188.17 EXF75505.1 - 8.3e-12 45.6 0.0 3.5e-11 43.6 0.0 2.1 2 0 0 2 2 2 1 MutS domain II MutS_IV PF05190.18 EXF75505.1 - 0.00011 22.5 0.0 0.0003 21.1 0.0 1.8 1 0 0 1 1 1 1 MutS family domain IV AAA_27 PF13514.6 EXF75505.1 - 0.0062 16.2 0.0 0.19 11.3 0.0 2.5 2 0 0 2 2 2 1 AAA domain DUF4911 PF16256.5 EXF75505.1 - 0.0073 16.3 0.1 0.018 15.0 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4911) AAA_29 PF13555.6 EXF75505.1 - 0.13 12.1 0.1 0.36 10.6 0.1 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain ORC6 PF05460.13 EXF75505.1 - 0.29 10.3 9.2 0.55 9.4 9.2 1.3 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Abhydrolase_3 PF07859.13 EXF75506.1 - 2.7e-42 145.0 0.0 3.4e-42 144.7 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 EXF75506.1 - 0.0016 17.4 0.1 0.003 16.5 0.1 1.4 1 1 0 1 1 1 1 Carboxylesterase family COX17 PF05051.13 EXF75507.1 - 7.4e-21 74.2 6.1 8.7e-21 74.0 6.1 1.1 1 0 0 1 1 1 1 Cytochrome C oxidase copper chaperone (COX17) G-patch PF01585.23 EXF75508.1 - 0.00018 21.4 0.0 0.00074 19.4 0.0 2.2 1 1 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 EXF75508.1 - 0.074 13.2 0.0 0.074 13.2 0.0 4.4 3 2 0 3 3 3 0 G-patch domain GREB1 PF15782.5 EXF75508.1 - 0.38 7.8 28.7 0.45 7.6 28.7 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Borrelia_P83 PF05262.11 EXF75508.1 - 1.6 7.2 41.4 2.5 6.5 41.4 1.3 1 0 0 1 1 1 0 Borrelia P83/100 protein Mitofilin PF09731.9 EXF75508.1 - 4.6 6.0 52.6 6.4 5.5 52.6 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein AF-4 PF05110.13 EXF75508.1 - 5.6 4.9 53.5 7.1 4.6 53.5 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein TFIIF_alpha PF05793.12 EXF75508.1 - 6.7 5.2 68.9 13 4.2 68.9 1.4 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) PITH PF06201.13 EXF75514.1 - 4.3e-35 121.2 0.0 6.1e-35 120.7 0.0 1.2 1 0 0 1 1 1 1 PITH domain Thioredoxin PF00085.20 EXF75514.1 - 8.8e-28 96.3 0.0 1.5e-27 95.6 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin OST3_OST6 PF04756.13 EXF75514.1 - 3.6e-06 26.5 0.0 5.6e-06 25.9 0.0 1.2 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_8 PF13905.6 EXF75514.1 - 7.6e-06 26.2 0.0 0.00021 21.6 0.0 2.3 1 1 1 2 2 2 1 Thioredoxin-like Thioredoxin_2 PF13098.6 EXF75514.1 - 1.5e-05 25.4 0.1 6.9e-05 23.3 0.1 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain AhpC-TSA PF00578.21 EXF75514.1 - 0.0026 17.7 0.0 0.0078 16.1 0.0 1.8 2 0 0 2 2 2 1 AhpC/TSA family Thioredoxin_7 PF13899.6 EXF75514.1 - 0.003 17.7 0.0 0.0062 16.7 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_9 PF14595.6 EXF75514.1 - 0.027 14.2 0.0 0.047 13.5 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin Serglycin PF04360.12 EXF75514.1 - 0.06 13.3 0.7 0.11 12.4 0.7 1.4 1 0 0 1 1 1 0 Serglycin HyaE PF07449.11 EXF75514.1 - 0.09 12.7 0.0 0.24 11.4 0.0 1.7 2 0 0 2 2 2 0 Hydrogenase-1 expression protein HyaE DUF1207 PF06727.11 EXF75514.1 - 0.16 10.8 0.0 0.26 10.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1207) PRANC PF09372.10 EXF75516.1 - 0.066 13.5 0.3 1.4 9.3 0.1 2.6 2 0 0 2 2 2 0 PRANC domain Rtt106_N PF18215.1 EXF75516.1 - 0.15 11.8 0.0 7.2 6.4 0.0 2.4 2 0 0 2 2 2 0 Histone chaperone Rtt106 N-terminal domain DivIC PF04977.15 EXF75517.1 - 0.019 14.7 1.1 0.033 14.0 1.1 1.3 1 0 0 1 1 1 0 Septum formation initiator GAS PF13851.6 EXF75517.1 - 0.053 12.9 0.1 0.084 12.2 0.1 1.2 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding HAP1_N PF04849.13 EXF75517.1 - 0.093 11.9 0.3 0.14 11.4 0.3 1.1 1 0 0 1 1 1 0 HAP1 N-terminal conserved region TolA_bind_tri PF16331.5 EXF75517.1 - 0.12 12.4 0.3 0.2 11.7 0.3 1.3 1 0 0 1 1 1 0 TolA binding protein trimerisation FlaC_arch PF05377.11 EXF75517.1 - 0.26 11.7 0.6 0.55 10.7 0.6 1.5 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) ADH_zinc_N PF00107.26 EXF75518.1 - 6.6e-11 42.3 0.0 1.7e-10 40.9 0.0 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EXF75518.1 - 0.00082 19.2 0.0 0.0026 17.6 0.0 2.0 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain adh_short PF00106.25 EXF75518.1 - 0.023 14.2 0.1 0.039 13.4 0.1 1.3 1 0 0 1 1 1 0 short chain dehydrogenase AlaDh_PNT_C PF01262.21 EXF75518.1 - 0.19 11.0 1.9 0.3 10.3 1.9 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain CorA PF01544.18 EXF75520.1 - 3.2e-15 56.2 5.3 1.5e-11 44.2 0.0 3.1 3 0 0 3 3 3 2 CorA-like Mg2+ transporter protein RhoGAP PF00620.27 EXF75522.1 - 9.6e-45 152.1 0.2 5.3e-44 149.7 0.2 2.1 2 0 0 2 2 2 1 RhoGAP domain PH PF00169.29 EXF75522.1 - 1.9e-11 44.4 0.0 4.2e-11 43.3 0.0 1.6 1 0 0 1 1 1 1 PH domain PH_8 PF15409.6 EXF75522.1 - 0.019 15.2 0.1 0.28 11.5 0.0 2.4 2 0 0 2 2 2 0 Pleckstrin homology domain Zn_clus PF00172.18 EXF75523.1 - 0.00016 21.7 10.8 0.00026 21.1 10.8 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EXF75523.1 - 0.001 18.2 0.0 0.0017 17.4 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Ctr PF04145.15 EXF75524.1 - 1.3e-10 42.0 0.0 1.7e-10 41.7 0.0 1.3 1 1 0 1 1 1 1 Ctr copper transporter family OPT PF03169.15 EXF75525.1 - 1.1e-135 453.8 54.1 1.2e-135 453.6 54.1 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein RlaP PF10127.9 EXF75527.1 - 0.017 14.7 0.0 0.37 10.3 0.0 2.0 1 1 1 2 2 2 0 RNA repair pathway DNA polymerase beta family Fungal_trans PF04082.18 EXF75528.1 - 3.6e-05 22.9 0.0 7.7e-05 21.8 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain MFS_1 PF07690.16 EXF75530.1 - 1.3e-27 96.7 61.4 1.2e-19 70.5 32.5 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF75530.1 - 0.0063 15.4 46.4 0.0079 15.1 17.3 3.7 2 2 2 4 4 4 3 Sugar (and other) transporter AIM24 PF01987.17 EXF75531.1 - 1e-50 172.3 0.0 1.3e-50 172.1 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial biogenesis AIM24 Tax PF02959.16 EXF75531.1 - 0.058 12.8 0.1 0.1 12.0 0.1 1.3 1 0 0 1 1 1 0 HTLV Tax Kinesin PF00225.23 EXF75532.1 - 1.7e-80 270.5 0.0 2.3e-80 270.0 0.0 1.2 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EXF75532.1 - 1.6e-19 70.3 0.0 2.9e-19 69.5 0.0 1.4 1 0 0 1 1 1 1 Microtubule binding HHH_3 PF12836.7 EXF75532.1 - 0.0098 16.1 0.0 0.042 14.1 0.0 2.1 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_5 PF14520.6 EXF75532.1 - 0.028 15.0 0.0 0.68 10.6 0.1 2.9 2 1 1 3 3 3 0 Helix-hairpin-helix domain ARS2 PF04959.13 EXF75532.1 - 0.042 14.2 0.1 1.6 9.1 0.2 2.5 2 0 0 2 2 2 0 Arsenite-resistance protein 2 PBP1_TM PF14812.6 EXF75532.1 - 0.056 13.8 2.6 0.17 12.2 2.6 1.8 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal MerR-DNA-bind PF09278.11 EXF75532.1 - 0.31 11.6 3.5 1.4 9.5 0.6 2.9 1 1 1 2 2 2 0 MerR, DNA binding p450 PF00067.22 EXF75533.1 - 1.4e-39 136.1 1.1 4.9e-25 88.2 0.1 2.0 2 0 0 2 2 2 2 Cytochrome P450 GlutR_dimer PF00745.20 EXF75534.1 - 0.093 13.2 0.3 0.21 12.0 0.3 1.6 1 0 0 1 1 1 0 Glutamyl-tRNAGlu reductase, dimerisation domain Iso_dh PF00180.20 EXF75535.1 - 3.5e-117 391.4 0.0 4.2e-117 391.2 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase CN_hydrolase PF00795.22 EXF75536.1 - 1.4e-20 73.8 0.0 2.3e-20 73.0 0.0 1.3 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase MFS_1 PF07690.16 EXF75537.1 - 2.6e-36 125.3 39.6 1.1e-35 123.2 37.6 2.5 1 1 0 1 1 1 1 Major Facilitator Superfamily OATP PF03137.20 EXF75537.1 - 0.0019 16.6 1.7 0.0019 16.6 1.7 1.7 2 0 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family Zn_clus PF00172.18 EXF75538.1 - 3.8e-06 26.9 9.2 3.8e-06 26.9 9.2 1.7 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain M-inducer_phosp PF06617.13 EXF75538.1 - 1.5 8.1 8.9 0.68 9.2 3.9 2.1 2 0 0 2 2 2 0 M-phase inducer phosphatase Dioxygenase_C PF00775.21 EXF75540.1 - 1.3e-09 37.7 0.4 2.8e-09 36.7 0.4 1.6 1 1 0 1 1 1 1 Dioxygenase HET PF06985.11 EXF75541.1 - 1.2e-14 54.9 0.1 3.2e-14 53.5 0.1 1.8 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) SDA1 PF05285.12 EXF75541.1 - 0.0064 16.0 8.5 0.0097 15.4 8.5 1.2 1 0 0 1 1 1 1 SDA1 TFIIA PF03153.13 EXF75541.1 - 0.05 13.6 4.7 0.074 13.0 4.7 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CDC45 PF02724.14 EXF75541.1 - 0.13 10.5 7.6 0.23 9.7 7.6 1.3 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 EXF75541.1 - 0.31 9.2 8.7 0.42 8.8 8.7 1.1 1 0 0 1 1 1 0 Nop14-like family RRN3 PF05327.11 EXF75541.1 - 0.61 8.6 5.9 0.9 8.0 5.9 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 CobT PF06213.12 EXF75541.1 - 1.2 8.5 10.3 1.9 7.8 10.3 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Amidase PF01425.21 EXF75542.1 - 1e-96 324.7 0.0 7.1e-83 279.1 0.0 2.0 2 0 0 2 2 2 2 Amidase Zn_clus PF00172.18 EXF75543.1 - 1.1e-08 35.1 8.7 2e-08 34.2 8.7 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TRI12 PF06609.13 EXF75544.1 - 2.2e-81 274.1 17.2 2.6e-81 273.8 17.2 1.0 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_1 PF07690.16 EXF75544.1 - 3.2e-28 98.7 48.5 8e-28 97.4 46.2 2.4 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF75544.1 - 1.5e-10 40.6 3.9 1.5e-10 40.6 3.9 2.7 3 0 0 3 3 3 1 Sugar (and other) transporter ECH_1 PF00378.20 EXF75545.1 - 2.9e-58 197.1 0.0 3.7e-58 196.8 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EXF75545.1 - 1.9e-26 93.4 0.1 2.2e-25 89.8 0.1 1.9 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 EXF75546.1 - 3.9e-42 144.3 0.0 4.9e-42 144.0 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EXF75546.1 - 2.3e-18 66.8 0.0 1.5e-16 60.8 0.0 2.0 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase MaoC_dehydratas PF01575.19 EXF75547.1 - 1.3e-23 82.9 0.0 2.1e-23 82.2 0.0 1.3 1 0 0 1 1 1 1 MaoC like domain MaoC_dehydrat_N PF13452.6 EXF75547.1 - 3.2e-06 27.3 0.0 0.0024 18.0 0.0 2.3 2 0 0 2 2 2 2 N-terminal half of MaoC dehydratase AtuA PF07287.11 EXF75548.1 - 1.6e-127 425.0 0.0 2e-127 424.8 0.0 1.1 1 0 0 1 1 1 1 Acyclic terpene utilisation family protein AtuA AMP-binding PF00501.28 EXF75549.1 - 3.2e-73 246.7 0.0 4.1e-73 246.4 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EXF75549.1 - 5.7e-10 40.0 0.0 1.2e-09 39.0 0.0 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain DUF4448 PF14610.6 EXF75550.1 - 1.8e-33 115.9 0.0 2.6e-33 115.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) GT87 PF09594.10 EXF75550.1 - 0.033 13.9 2.3 0.063 13.0 0.1 2.0 2 0 0 2 2 2 0 Glycosyltransferase family 87 DUF4181 PF13789.6 EXF75550.1 - 0.086 13.1 0.0 0.15 12.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4181) SGL PF08450.12 EXF75552.1 - 4.6e-05 23.1 0.9 0.0097 15.5 0.0 2.7 3 0 0 3 3 3 2 SMP-30/Gluconolactonase/LRE-like region GSDH PF07995.11 EXF75552.1 - 0.17 11.2 1.3 0.83 8.9 0.7 2.6 2 1 0 2 2 2 0 Glucose / Sorbosone dehydrogenase KH_1 PF00013.29 EXF75554.1 - 0.055 13.3 0.0 0.089 12.6 0.0 1.3 1 0 0 1 1 1 0 KH domain SAD_SRA PF02182.17 EXF75555.1 - 2.2e-09 37.2 0.0 4e-09 36.4 0.0 1.3 1 0 0 1 1 1 1 SAD/SRA domain Lipase_GDSL_2 PF13472.6 EXF75560.1 - 3.9e-10 40.4 2.0 7.3e-10 39.5 2.0 1.5 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EXF75560.1 - 8.9e-10 38.9 0.0 1.5e-09 38.1 0.0 1.4 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase DUF4185 PF13810.6 EXF75560.1 - 0.11 11.7 0.0 0.16 11.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4185) ASCH PF04266.14 EXF75561.1 - 1.1e-17 64.5 0.1 1.4e-17 64.2 0.1 1.1 1 0 0 1 1 1 1 ASCH domain p450 PF00067.22 EXF75562.1 - 1e-47 162.9 0.0 1.5e-47 162.5 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Zn_clus PF00172.18 EXF75563.1 - 0.0053 16.8 10.5 0.017 15.2 10.5 1.9 1 1 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RTA1 PF04479.13 EXF75564.1 - 1.8e-54 184.5 11.4 1.8e-54 184.5 11.4 1.5 1 1 1 2 2 2 1 RTA1 like protein DUF2964 PF11177.8 EXF75564.1 - 0.26 11.5 3.1 6.4 7.1 0.5 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2964) AAA_33 PF13671.6 EXF75565.1 - 0.072 13.2 0.0 0.12 12.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain Fungal_trans PF04082.18 EXF75566.1 - 5.9e-25 87.8 0.1 9.4e-25 87.1 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Amidohydro_1 PF01979.20 EXF75567.1 - 2.6e-45 155.2 0.0 4.2e-45 154.5 0.0 1.3 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EXF75567.1 - 3.3e-17 63.1 0.6 3.5e-11 43.2 0.0 2.4 2 0 0 2 2 2 2 Amidohydrolase family MFS_1 PF07690.16 EXF75568.1 - 6.1e-34 117.5 34.6 8.3e-34 117.0 34.2 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily MFS_1 PF07690.16 EXF75569.1 - 1e-33 116.7 36.7 1e-33 116.7 36.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily zf-C2H2_12 PF18658.1 EXF75570.1 - 0.0047 16.5 0.1 0.0064 16.1 0.1 1.3 1 0 0 1 1 1 1 Zinc-finger C2H2-type zf-C2H2 PF00096.26 EXF75570.1 - 0.018 15.4 2.9 0.027 14.9 2.9 1.3 1 0 0 1 1 1 0 Zinc finger, C2H2 type DUF629 PF04780.12 EXF75570.1 - 0.057 11.9 0.0 0.064 11.8 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF629) zf-C2H2_4 PF13894.6 EXF75570.1 - 0.17 12.8 2.0 0.27 12.2 2.0 1.3 1 0 0 1 1 1 0 C2H2-type zinc finger zf-BED PF02892.15 EXF75570.1 - 0.23 11.5 2.0 0.45 10.6 2.0 1.5 1 0 0 1 1 1 0 BED zinc finger DUF5597 PF18120.1 EXF75571.1 - 0.15 12.2 0.0 0.38 10.9 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF5597) Methyltransf_23 PF13489.6 EXF75572.1 - 1.5e-22 80.2 0.0 2.6e-22 79.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF75572.1 - 9.8e-08 32.6 0.0 3.5e-07 30.8 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF75572.1 - 1.8e-07 31.1 0.0 4.9e-06 26.4 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF75572.1 - 1e-05 26.1 0.0 2.1e-05 25.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EXF75572.1 - 0.00023 20.8 0.0 0.00043 19.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_12 PF08242.12 EXF75572.1 - 0.00049 20.8 0.0 0.0047 17.6 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.18 EXF75572.1 - 0.0037 16.6 0.0 0.042 13.1 0.0 2.0 2 0 0 2 2 2 1 O-methyltransferase domain PrmA PF06325.13 EXF75572.1 - 0.12 11.7 0.0 0.19 11.1 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_4 PF02390.17 EXF75572.1 - 0.19 11.2 0.0 0.33 10.4 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase Glyco_hydro_43 PF04616.14 EXF75573.1 - 2.3e-34 119.1 3.5 3.2e-34 118.6 3.5 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 GH43_C2 PF17851.1 EXF75573.1 - 7.7e-21 74.7 0.0 1.1e-20 74.2 0.0 1.2 1 0 0 1 1 1 1 Beta xylosidase C-terminal Concanavalin A-like domain AA_permease_2 PF13520.6 EXF75574.1 - 7.9e-42 143.6 55.3 9.8e-41 140.0 55.3 1.9 1 1 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EXF75574.1 - 8e-24 84.1 47.3 3.2e-19 68.9 30.5 2.1 2 0 0 2 2 2 2 Amino acid permease AcrZ PF10766.9 EXF75574.1 - 2.6 7.7 8.7 4.1 7.0 3.2 3.4 2 0 0 2 2 2 0 Multidrug efflux pump-associated protein AcrZ p450 PF00067.22 EXF75577.1 - 6e-40 137.4 0.0 2e-39 135.6 0.0 1.7 1 1 0 1 1 1 1 Cytochrome P450 Aminotran_3 PF00202.21 EXF75578.1 - 1.2e-30 106.5 0.0 3.9e-24 85.1 0.0 2.0 1 1 1 2 2 2 2 Aminotransferase class-III Fungal_trans_2 PF11951.8 EXF75579.1 - 1.8e-20 73.1 1.3 3.2e-20 72.3 1.3 1.4 1 1 0 1 1 1 1 Fungal specific transcription factor domain Arginase PF00491.21 EXF75580.1 - 2.9e-82 276.3 0.0 4.2e-82 275.8 0.0 1.1 1 0 0 1 1 1 1 Arginase family UPF0489 PF12640.7 EXF75580.1 - 0.057 13.6 0.2 0.091 13.0 0.1 1.4 1 1 0 1 1 1 0 UPF0489 domain MatE PF01554.18 EXF75581.1 - 1.4e-50 171.1 23.2 3.7e-26 91.7 8.1 2.3 2 0 0 2 2 2 2 MatE Polysacc_synt_C PF14667.6 EXF75581.1 - 3.5e-08 33.6 5.7 3.5e-08 33.6 5.7 3.8 3 2 0 3 3 3 2 Polysaccharide biosynthesis C-terminal domain MFS_1 PF07690.16 EXF75582.1 - 7.5e-22 77.7 9.8 9.9e-22 77.3 9.8 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF75582.1 - 5.4e-10 38.7 5.3 6.7e-10 38.4 5.3 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter TRI12 PF06609.13 EXF75582.1 - 3.2e-05 22.5 1.9 4e-05 22.2 1.9 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_2 PF13347.6 EXF75582.1 - 0.015 13.9 3.3 0.019 13.6 3.3 1.1 1 0 0 1 1 1 0 MFS/sugar transport protein OATP PF03137.20 EXF75582.1 - 1.1 7.5 4.8 6 5.0 0.2 2.0 1 1 1 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family PD40 PF07676.12 EXF75583.1 - 0.01 15.7 0.8 0.024 14.6 0.1 2.1 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat Proteasome_A_N PF10584.9 EXF75583.1 - 0.056 13.1 0.2 0.14 11.9 0.2 1.7 1 0 0 1 1 1 0 Proteasome subunit A N-terminal signature ATP-synt_C PF00137.21 EXF75585.1 - 2e-11 44.1 25.5 4.6e-08 33.3 7.8 2.1 2 0 0 2 2 2 2 ATP synthase subunit C Asp PF00026.23 EXF75586.1 - 8.9e-73 245.4 6.0 1.1e-72 245.2 6.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EXF75586.1 - 2.4e-13 50.7 4.9 1.8e-11 44.6 3.8 3.5 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EXF75586.1 - 2.3e-06 28.1 1.7 0.021 15.4 0.3 3.8 2 1 0 2 2 2 2 Aspartyl protease TAXi_C PF14541.6 EXF75586.1 - 0.0052 16.6 0.0 0.03 14.1 0.0 2.1 2 0 0 2 2 2 1 Xylanase inhibitor C-terminal MFS_1 PF07690.16 EXF75587.1 - 9.1e-38 130.1 51.1 7.9e-37 127.0 50.4 2.5 2 1 0 2 2 2 1 Major Facilitator Superfamily MFS_1 PF07690.16 EXF75588.1 - 2.7e-49 168.0 53.4 6.2e-49 166.8 51.6 2.3 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EXF75588.1 - 9e-16 57.4 18.7 9e-16 57.4 18.7 1.4 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EXF75588.1 - 3.8e-13 49.1 10.4 3.8e-13 49.1 10.4 3.4 2 1 0 3 3 3 1 Sugar (and other) transporter DUF4181 PF13789.6 EXF75588.1 - 7 7.0 9.8 0.12 12.6 0.6 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4181) Mur_ligase_C PF02875.21 EXF75589.1 - 0.0015 18.8 0.1 0.018 15.3 0.0 2.9 3 0 0 3 3 3 1 Mur ligase family, glutamate ligase domain PAP1 PF08601.10 EXF75589.1 - 1 9.0 2.2 1.7 8.3 2.2 1.3 1 0 0 1 1 1 0 Transcription factor PAP1 Mur_ligase_M PF08245.12 EXF75590.1 - 0.00023 21.2 0.0 0.0013 18.7 0.0 2.0 1 1 0 1 1 1 1 Mur ligase middle domain Mur_ligase_C PF02875.21 EXF75590.1 - 0.01 16.0 0.0 0.025 14.8 0.0 1.6 1 0 0 1 1 1 0 Mur ligase family, glutamate ligase domain GPHH PF16905.5 EXF75590.1 - 0.17 11.7 0.0 0.81 9.5 0.0 2.1 2 0 0 2 2 2 0 Voltage-dependent L-type calcium channel, IQ-associated Mitofilin PF09731.9 EXF75591.1 - 2.7e-146 489.0 25.8 2.3e-123 413.2 21.6 2.1 2 0 0 2 2 2 2 Mitochondrial inner membrane protein DUF3496 PF12001.8 EXF75591.1 - 0.037 14.4 4.1 0.11 12.9 4.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3496) DUF1848 PF08902.11 EXF75591.1 - 0.31 10.7 1.4 0.38 10.4 0.6 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1848) HsbA PF12296.8 EXF75591.1 - 0.71 10.3 4.9 1.8 9.0 0.3 3.2 3 0 0 3 3 3 0 Hydrophobic surface binding protein A YlqD PF11068.8 EXF75591.1 - 1.3 9.4 9.0 5.3 7.4 5.1 2.4 1 1 1 2 2 2 0 YlqD protein Ras PF00071.22 EXF75592.1 - 1.9e-58 196.6 0.2 2.2e-58 196.4 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EXF75592.1 - 3.7e-36 124.0 0.1 7.7e-36 122.9 0.1 1.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EXF75592.1 - 9.9e-15 54.4 0.0 1.2e-14 54.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EXF75592.1 - 1.2e-06 28.0 0.0 1.5e-06 27.8 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EXF75592.1 - 2.2e-06 27.3 0.0 3.2e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EXF75592.1 - 2.6e-06 27.5 0.0 3.9e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EXF75592.1 - 1.6e-05 24.9 0.8 0.084 12.8 0.1 2.4 1 1 2 3 3 3 2 RsgA GTPase AAA_16 PF13191.6 EXF75592.1 - 0.025 15.0 0.2 0.047 14.1 0.2 1.5 1 1 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 EXF75592.1 - 0.051 13.9 0.0 5.1 7.4 0.0 2.3 1 1 1 2 2 2 0 AAA domain TniB PF05621.11 EXF75592.1 - 0.084 12.3 0.0 0.18 11.2 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein GbpA_2 PF18416.1 EXF75592.1 - 0.15 12.3 1.1 5.6 7.3 0.0 2.3 1 1 1 2 2 2 0 N-acetylglucosamine binding protein domain 2 Syja_N PF02383.18 EXF75593.1 - 1.3e-87 294.2 0.0 1.6e-87 293.8 0.0 1.1 1 0 0 1 1 1 1 SacI homology domain ABC2_membrane_3 PF12698.7 EXF75593.1 - 2.4 7.2 6.1 4.1 6.4 6.1 1.3 1 0 0 1 1 1 0 ABC-2 family transporter protein Esterase_phd PF10503.9 EXF75594.1 - 4.3e-22 78.7 0.3 6.2e-22 78.2 0.3 1.2 1 0 0 1 1 1 1 Esterase PHB depolymerase CBM_1 PF00734.18 EXF75594.1 - 7.2e-12 45.1 16.8 4.8e-11 42.4 16.8 2.6 1 0 0 1 1 1 1 Fungal cellulose binding domain Peptidase_S9 PF00326.21 EXF75594.1 - 7.1e-10 38.7 1.0 1.1e-09 38.1 1.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family COesterase PF00135.28 EXF75594.1 - 0.019 13.9 0.8 0.034 13.0 0.8 1.5 1 1 0 1 1 1 0 Carboxylesterase family Esterase PF00756.20 EXF75594.1 - 0.022 14.4 0.8 0.032 13.9 0.8 1.2 1 0 0 1 1 1 0 Putative esterase Abhydrolase_3 PF07859.13 EXF75594.1 - 0.062 13.2 0.0 0.093 12.6 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 EXF75594.1 - 0.077 12.8 0.1 0.14 11.9 0.1 1.4 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase MFS_1 PF07690.16 EXF75595.1 - 8.2e-20 71.0 24.8 8.2e-20 71.0 24.8 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily CENP-B_N PF04218.13 EXF75595.1 - 0.0019 17.8 0.0 0.0038 16.8 0.0 1.4 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain Trp_oprn_chp PF09534.10 EXF75595.1 - 0.54 10.0 6.5 3.2 7.5 0.4 3.3 1 1 1 3 3 3 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) DUF2109 PF09882.9 EXF75595.1 - 6 6.9 12.3 2.3 8.3 0.6 4.2 5 0 0 5 5 5 0 Predicted membrane protein (DUF2109) GST_N_4 PF17172.4 EXF75597.1 - 8.8e-19 68.1 0.0 2.1e-18 66.9 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain GST_C_6 PF17171.4 EXF75597.1 - 6.1e-06 25.9 0.0 1.5e-05 24.7 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Tom37 PF10568.9 EXF75597.1 - 0.00022 21.6 0.0 0.00035 20.9 0.0 1.3 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein GST_C_2 PF13410.6 EXF75597.1 - 0.072 13.1 0.0 0.17 11.9 0.0 1.8 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain UPF0183 PF03676.14 EXF75598.1 - 5.1e-54 184.1 0.0 1.7e-31 109.9 0.0 3.6 3 1 0 3 3 3 3 Uncharacterised protein family (UPF0183) Kinesin PF00225.23 EXF75599.1 - 1.3e-107 359.6 0.1 1.3e-107 359.6 0.1 2.2 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 EXF75599.1 - 9.7e-25 87.2 0.4 6.1e-24 84.7 0.0 2.8 2 0 0 2 2 2 1 Microtubule binding Microtub_bind PF13931.6 EXF75599.1 - 4.3e-07 30.4 1.3 4.3e-07 30.4 1.3 5.3 2 1 2 6 6 6 1 Kinesin-associated microtubule-binding Acetyltransf_10 PF13673.7 EXF75599.1 - 0.01 15.8 0.0 0.032 14.2 0.0 1.8 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain ESAG1 PF03238.13 EXF75599.1 - 0.016 14.7 0.2 0.86 9.0 0.3 2.8 1 1 1 2 2 2 0 ESAG protein Acetyltransf_1 PF00583.25 EXF75599.1 - 0.034 14.4 0.1 0.076 13.3 0.1 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EXF75599.1 - 0.067 13.6 0.1 0.15 12.5 0.1 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Apolipoprotein PF01442.18 EXF75599.1 - 0.38 10.6 67.5 0.093 12.6 19.7 4.5 1 1 2 3 3 3 0 Apolipoprotein A1/A4/E domain HAD_2 PF13419.6 EXF75600.1 - 0.0025 17.9 0.0 0.0046 17.1 0.0 1.4 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Glyco_hydro_79C PF16862.5 EXF75601.1 - 1.1e-23 84.1 1.6 1.8e-23 83.4 0.5 2.0 2 0 0 2 2 2 1 Glycosyl hydrolase family 79 C-terminal beta domain Aldedh PF00171.22 EXF75602.1 - 1.5e-168 561.1 1.1 1.7e-168 560.9 1.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family tRNA-synt_1 PF00133.22 EXF75603.1 - 2.1e-154 515.1 0.0 3.1e-154 514.5 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 EXF75603.1 - 2e-18 66.8 0.0 4e-18 65.8 0.0 1.5 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 EXF75603.1 - 7e-17 61.2 0.0 2.8e-10 39.5 0.0 3.2 3 0 0 3 3 3 3 tRNA synthetases class I (M) zf-FPG_IleRS PF06827.14 EXF75603.1 - 0.058 13.3 9.3 0.038 13.9 6.2 2.3 2 1 0 2 2 2 0 Zinc finger found in FPG and IleRS tRNA-synt_1e PF01406.19 EXF75603.1 - 0.1 11.9 0.0 13 5.0 0.0 2.3 2 0 0 2 2 2 0 tRNA synthetases class I (C) catalytic domain PRP9_N PF16958.5 EXF75604.1 - 0.012 15.7 0.6 0.024 14.7 0.6 1.5 1 0 0 1 1 1 0 Pre-mRNA-splicing factor PRP9 N-terminus RRM_1 PF00076.22 EXF75606.1 - 1.2e-07 31.5 0.2 3.3e-07 30.0 0.0 1.9 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CTD_bind PF04818.13 EXF75606.1 - 0.00031 21.5 0.0 0.00094 20.0 0.0 1.9 2 0 0 2 2 2 1 RNA polymerase II-binding domain. Citrate_synt PF00285.21 EXF75607.1 - 1.1e-101 340.5 0.0 1.5e-101 340.1 0.0 1.1 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain Eclosion PF04736.12 EXF75607.1 - 0.032 13.9 0.0 0.07 12.8 0.0 1.5 1 0 0 1 1 1 0 Eclosion hormone Mito_carr PF00153.27 EXF75608.1 - 6.9e-28 96.4 4.0 7e-13 48.3 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Fungal_trans PF04082.18 EXF75609.1 - 6.5e-12 45.0 0.2 1e-11 44.4 0.2 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF75609.1 - 6.3e-08 32.6 11.9 9.9e-08 32.0 11.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain UbiD PF01977.16 EXF75610.1 - 9.8e-122 406.7 0.0 1.1e-121 406.5 0.0 1.0 1 0 0 1 1 1 1 3-octaprenyl-4-hydroxybenzoate carboxy-lyase Flavoprotein PF02441.19 EXF75611.1 - 1.4e-23 83.4 0.1 1.8e-23 83.1 0.1 1.1 1 0 0 1 1 1 1 Flavoprotein Fungal_trans PF04082.18 EXF75612.1 - 6.9e-11 41.7 0.1 2.2e-10 40.0 0.0 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain Gag_MA PF01140.19 EXF75612.1 - 0.12 12.1 0.0 0.24 11.1 0.0 1.4 1 0 0 1 1 1 0 Matrix protein (MA), p15 BCS1_N PF08740.11 EXF75613.1 - 5.5e-36 124.3 0.2 1e-35 123.4 0.2 1.5 1 0 0 1 1 1 1 BCS1 N terminal MFS_1 PF07690.16 EXF75613.1 - 2.8e-27 95.6 48.3 1.2e-20 73.8 24.9 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily AAA PF00004.29 EXF75613.1 - 5.8e-22 78.5 0.0 1.4e-21 77.3 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EXF75613.1 - 1.9e-05 24.4 0.0 3.9e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 EXF75613.1 - 0.024 15.2 0.0 0.046 14.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EXF75613.1 - 0.06 13.7 0.0 0.16 12.4 0.0 1.7 1 0 0 1 1 1 0 RNA helicase DUF815 PF05673.13 EXF75613.1 - 0.075 12.2 0.0 0.12 11.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_5 PF07728.14 EXF75613.1 - 0.14 12.2 0.0 0.38 10.8 0.0 1.7 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EXF75613.1 - 0.19 12.1 0.0 0.53 10.6 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain BNR_2 PF13088.6 EXF75615.1 - 3.5e-08 33.1 1.2 0.0011 18.3 0.2 2.5 2 0 0 2 2 2 2 BNR repeat-like domain Epimerase PF01370.21 EXF75616.1 - 2e-12 47.1 0.3 4.7e-12 45.9 0.3 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 EXF75616.1 - 3.4e-08 33.0 0.9 0.00052 19.3 0.1 2.2 1 1 0 2 2 2 2 Male sterility protein NAD_binding_10 PF13460.6 EXF75616.1 - 1.9e-06 27.9 1.0 2e-05 24.6 1.0 2.3 1 1 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 EXF75616.1 - 0.00014 20.9 0.0 0.00037 19.6 0.0 1.6 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family NmrA PF05368.13 EXF75616.1 - 0.00056 19.5 0.6 0.0011 18.6 0.2 1.7 2 1 0 2 2 2 1 NmrA-like family Sacchrp_dh_NADP PF03435.18 EXF75616.1 - 0.0019 18.5 0.1 0.0032 17.7 0.1 1.6 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain tRNA_Me_trans PF03054.16 EXF75616.1 - 0.02 13.7 0.2 0.026 13.3 0.2 1.1 1 0 0 1 1 1 0 tRNA methyl transferase GDP_Man_Dehyd PF16363.5 EXF75616.1 - 0.039 13.3 0.2 0.083 12.3 0.2 1.5 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 EXF75616.1 - 0.096 11.8 0.0 0.17 10.9 0.0 1.4 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein MFS_1 PF07690.16 EXF75617.1 - 1.9e-31 109.3 14.4 4.6e-27 94.9 12.7 2.7 2 1 1 3 3 3 2 Major Facilitator Superfamily DUF2427 PF10348.9 EXF75617.1 - 0.76 9.6 6.9 0.17 11.7 1.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF2427) Fungal_trans PF04082.18 EXF75618.1 - 3.9e-15 55.6 1.1 8.5e-15 54.5 1.1 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Bac_rhamnosid_C PF17390.2 EXF75619.1 - 5.2e-07 29.4 0.1 1.1e-06 28.3 0.1 1.6 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase C-terminal domain Bac_rhamnosid6H PF17389.2 EXF75619.1 - 0.0012 18.2 0.1 0.5 9.6 0.0 2.3 2 0 0 2 2 2 2 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain DUF1080 PF06439.11 EXF75619.1 - 0.016 15.3 0.0 0.032 14.3 0.0 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1080) Sugar_tr PF00083.24 EXF75620.1 - 2.2e-90 303.7 24.8 2.7e-90 303.4 24.8 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF75620.1 - 4.8e-15 55.3 46.4 5.7e-09 35.4 20.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2838 PF10998.8 EXF75620.1 - 2.5 8.4 7.6 1.7 8.9 1.8 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2838) TAL_FSA PF00923.19 EXF75621.1 - 2.2e-32 112.6 0.0 3.3e-32 112.0 0.0 1.2 1 0 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase HLH PF00010.26 EXF75622.1 - 0.0001 22.2 0.1 0.00026 20.9 0.1 1.7 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain SMN PF06003.12 EXF75622.1 - 0.09 12.0 0.6 0.12 11.6 0.6 1.2 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) SRR1 PF07985.12 EXF75623.1 - 3.6e-10 39.7 0.0 6.1e-10 39.0 0.0 1.4 1 0 0 1 1 1 1 SRR1 Med13_N PF11597.8 EXF75623.1 - 0.093 12.1 0.0 0.12 11.8 0.0 1.2 1 0 0 1 1 1 0 Mediator complex subunit 13 N-terminal AMPK1_CBM PF16561.5 EXF75623.1 - 0.15 12.3 0.1 0.32 11.2 0.1 1.6 1 0 0 1 1 1 0 Glycogen recognition site of AMP-activated protein kinase PUL PF08324.11 EXF75625.1 - 1.2e-66 224.9 0.7 1.7e-66 224.3 0.7 1.3 1 0 0 1 1 1 1 PUL domain PFU PF09070.11 EXF75625.1 - 7.4e-45 151.9 0.2 1.2e-44 151.1 0.2 1.4 1 0 0 1 1 1 1 PFU (PLAA family ubiquitin binding) WD40 PF00400.32 EXF75625.1 - 8.1e-34 115.1 3.0 2.9e-06 27.9 0.0 7.7 7 0 0 7 7 7 6 WD domain, G-beta repeat WD40_like PF17005.5 EXF75625.1 - 0.00067 19.1 0.0 0.0035 16.7 0.0 2.1 2 0 0 2 2 2 1 WD40-like domain WD40 PF00400.32 EXF75626.1 - 3.8e-23 81.3 3.4 7.5e-08 32.9 0.0 5.2 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EXF75626.1 - 0.00039 20.7 0.1 2.3 8.5 0.0 3.6 2 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EXF75626.1 - 0.0036 16.3 0.0 0.58 9.1 0.0 2.2 2 0 0 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Abhydrolase_3 PF07859.13 EXF75627.1 - 2.6e-19 69.9 0.0 4e-19 69.3 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Chlorophyllase2 PF12740.7 EXF75627.1 - 0.00011 21.3 0.0 0.00015 20.8 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase enzyme Peptidase_S9 PF00326.21 EXF75627.1 - 0.00017 21.1 0.0 0.001 18.6 0.0 2.0 2 0 0 2 2 2 1 Prolyl oligopeptidase family Chlorophyllase PF07224.11 EXF75627.1 - 0.0016 17.5 0.0 0.0022 17.1 0.0 1.1 1 0 0 1 1 1 1 Chlorophyllase COesterase PF00135.28 EXF75627.1 - 0.0017 17.3 0.0 0.0032 16.4 0.0 1.5 1 1 0 1 1 1 1 Carboxylesterase family AXE1 PF05448.12 EXF75627.1 - 0.0035 16.0 0.1 0.024 13.3 0.0 1.9 2 0 0 2 2 2 1 Acetyl xylan esterase (AXE1) Peptidase_S15 PF02129.18 EXF75627.1 - 0.035 13.7 0.0 0.079 12.5 0.0 1.6 1 1 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Esterase PF00756.20 EXF75627.1 - 0.079 12.6 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 Putative esterase Syndecan PF01034.20 EXF75628.1 - 0.0052 16.7 0.0 0.0097 15.8 0.0 1.4 1 0 0 1 1 1 1 Syndecan domain Rax2 PF12768.7 EXF75628.1 - 0.018 14.5 0.2 0.026 14.0 0.2 1.2 1 0 0 1 1 1 0 Cortical protein marker for cell polarity VSP PF03302.13 EXF75628.1 - 0.051 12.4 2.0 0.069 12.0 2.0 1.1 1 0 0 1 1 1 0 Giardia variant-specific surface protein PTP_tm PF18861.1 EXF75628.1 - 0.071 13.1 1.7 0.11 12.5 1.4 1.5 1 1 1 2 2 2 0 Transmembrane domain of protein tyrosine phosphatase, receptor type J DUF3328 PF11807.8 EXF75629.1 - 6e-17 62.2 0.1 1.6e-16 60.8 0.0 1.7 1 1 1 2 2 2 1 Domain of unknown function (DUF3328) Glyco_hydro_17 PF00332.18 EXF75630.1 - 4.5e-09 36.3 2.9 0.0006 19.5 0.1 2.2 1 1 1 2 2 2 2 Glycosyl hydrolases family 17 SNARE PF05739.19 EXF75630.1 - 0.041 13.9 1.2 0.074 13.1 1.2 1.4 1 0 0 1 1 1 0 SNARE domain Cupin_7 PF12973.7 EXF75631.1 - 0.13 12.2 0.4 0.77 9.7 0.1 2.2 2 0 0 2 2 2 0 ChrR Cupin-like domain Peroxidase_2 PF01328.17 EXF75632.1 - 2.6e-45 155.3 0.0 3.6e-45 154.8 0.0 1.1 1 0 0 1 1 1 1 Peroxidase, family 2 bZIP_1 PF00170.21 EXF75633.1 - 1.4e-07 31.5 8.1 2.3e-07 30.8 8.1 1.2 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EXF75633.1 - 1.6e-06 28.1 9.8 2.6e-06 27.4 9.8 1.2 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 EXF75633.1 - 0.00078 19.9 5.6 0.00078 19.9 5.6 1.5 2 0 0 2 2 2 1 bZIP Maf transcription factor Takusan PF04822.13 EXF75633.1 - 0.0013 18.5 2.8 0.0032 17.3 2.8 1.6 1 0 0 1 1 1 1 Takusan Adaptin_binding PF10199.9 EXF75633.1 - 0.05 14.2 0.3 0.055 14.1 0.3 1.3 1 1 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 TMF_DNA_bd PF12329.8 EXF75633.1 - 0.098 12.7 2.6 0.16 12.0 2.6 1.4 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding Fungal_trans PF04082.18 EXF75635.1 - 1.3e-10 40.8 0.0 2.1e-10 40.1 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain NICE-3 PF07406.11 EXF75635.1 - 0.11 12.5 0.0 0.19 11.7 0.0 1.3 1 0 0 1 1 1 0 NICE-3 protein DUF3070 PF11270.8 EXF75635.1 - 0.15 12.3 0.2 0.39 11.0 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3070) PP_kinase_N PF13089.6 EXF75636.1 - 0.093 13.1 0.3 0.093 13.1 0.3 2.6 1 1 1 2 2 2 0 Polyphosphate kinase N-terminal domain HsbA PF12296.8 EXF75637.1 - 1.7e-14 54.3 3.0 2.8e-14 53.6 3.0 1.3 1 0 0 1 1 1 1 Hydrophobic surface binding protein A OTT_1508_deam PF14441.6 EXF75638.1 - 7e-06 26.0 0.1 0.024 14.6 0.0 2.5 1 1 1 2 2 2 2 OTT_1508-like deaminase Tannase PF07519.11 EXF75639.1 - 7.3e-96 321.9 2.8 8.8e-96 321.6 2.8 1.0 1 0 0 1 1 1 1 Tannase and feruloyl esterase Peptidase_S9 PF00326.21 EXF75639.1 - 0.012 15.1 0.0 0.97 8.9 0.0 2.3 2 0 0 2 2 2 0 Prolyl oligopeptidase family IMS PF00817.20 EXF75640.1 - 2e-42 144.7 0.1 5.4e-42 143.3 0.1 1.8 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.8 EXF75640.1 - 1e-13 52.0 0.8 2.3e-13 50.9 0.0 1.9 2 0 0 2 2 2 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.8 EXF75640.1 - 0.00098 19.3 0.1 0.0027 17.9 0.1 1.8 1 0 0 1 1 1 1 IMS family HHH motif Nop PF01798.18 EXF75640.1 - 0.061 12.8 0.8 0.11 11.9 0.8 1.4 1 0 0 1 1 1 0 snoRNA binding domain, fibrillarin Arg_repressor PF01316.21 EXF75640.1 - 0.23 11.2 5.0 0.72 9.7 4.0 2.1 2 0 0 2 2 2 0 Arginine repressor, DNA binding domain DUF5371 PF17341.2 EXF75640.1 - 1.4 9.2 3.7 2.7 8.3 1.9 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5371) RGS PF00615.19 EXF75641.1 - 7.2e-06 26.3 0.0 2e-05 24.8 0.0 1.7 1 1 0 1 1 1 1 Regulator of G protein signaling domain Oxidored_q3 PF00499.20 EXF75641.1 - 0.035 13.8 4.5 0.035 13.8 3.3 1.7 1 1 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 p450 PF00067.22 EXF75642.1 - 4.8e-38 131.1 0.0 4.6e-24 85.0 0.0 2.1 2 0 0 2 2 2 2 Cytochrome P450 Peptidase_M61 PF05299.12 EXF75645.1 - 0.011 16.2 0.4 0.1 13.0 0.4 2.2 1 1 0 1 1 1 0 M61 glycyl aminopeptidase PDZ_6 PF17820.1 EXF75645.1 - 0.12 12.2 0.1 0.28 11.0 0.1 1.6 1 0 0 1 1 1 0 PDZ domain DUF3433 PF11915.8 EXF75646.1 - 6.9e-26 90.5 20.7 3.1e-20 72.4 2.2 3.2 3 0 0 3 3 3 2 Protein of unknown function (DUF3433) DUF3500 PF12006.8 EXF75647.1 - 2.1e-112 375.4 0.0 2.5e-112 375.2 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3500) FAA_hydrolase PF01557.18 EXF75648.1 - 2.3e-53 181.1 0.0 3e-53 180.7 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family RE_HaeIII PF09556.10 EXF75649.1 - 0.021 13.9 0.0 0.023 13.8 0.0 1.0 1 0 0 1 1 1 0 HaeIII restriction endonuclease Lys-AminoMut_A PF09043.11 EXF75649.1 - 0.025 13.0 0.0 0.029 12.9 0.0 1.0 1 0 0 1 1 1 0 D-Lysine 5,6-aminomutase TIM-barrel domain of alpha subunit B12-binding PF02310.19 EXF75649.1 - 0.069 13.2 0.1 0.11 12.6 0.1 1.3 1 0 0 1 1 1 0 B12 binding domain Lant_dehydr_N PF04738.13 EXF75649.1 - 0.08 11.0 0.0 0.083 11.0 0.0 1.0 1 0 0 1 1 1 0 Lantibiotic dehydratase, N terminus FAD_binding_3 PF01494.19 EXF75650.1 - 3.3e-22 79.2 0.0 5.2e-22 78.6 0.0 1.3 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.24 EXF75650.1 - 4e-12 46.4 1.1 6.4e-05 22.7 0.0 2.2 1 1 1 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EXF75650.1 - 7.6e-07 28.6 0.9 0.0014 17.9 0.4 2.3 1 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EXF75650.1 - 4.7e-06 27.1 0.6 0.00066 20.2 0.1 2.7 3 0 0 3 3 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EXF75650.1 - 6.4e-06 26.3 1.5 1.2e-05 25.5 0.8 1.8 2 0 0 2 2 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EXF75650.1 - 5.7e-05 22.4 1.5 9.9e-05 21.6 1.5 1.3 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 EXF75650.1 - 6.6e-05 21.8 0.7 0.00048 18.9 0.7 2.0 2 0 0 2 2 2 1 HI0933-like protein GIDA PF01134.22 EXF75650.1 - 0.001 18.2 0.6 0.0029 16.7 0.8 1.6 2 0 0 2 2 2 1 Glucose inhibited division protein A SE PF08491.10 EXF75650.1 - 0.0011 18.0 0.0 0.0028 16.8 0.0 1.6 1 1 0 1 1 1 1 Squalene epoxidase FAD_oxidored PF12831.7 EXF75650.1 - 0.0014 18.1 1.3 0.002 17.6 1.3 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.21 EXF75650.1 - 0.01 15.1 0.5 0.019 14.3 0.5 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Trp_halogenase PF04820.14 EXF75650.1 - 0.01 14.7 0.4 0.096 11.5 0.2 2.3 2 1 1 3 3 3 0 Tryptophan halogenase DUF3603 PF12227.8 EXF75650.1 - 0.015 14.6 0.0 0.025 13.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3603) 3HCDH_N PF02737.18 EXF75650.1 - 0.024 14.5 0.3 0.04 13.8 0.3 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Thi4 PF01946.17 EXF75650.1 - 0.032 13.5 0.4 0.051 12.8 0.4 1.2 1 0 0 1 1 1 0 Thi4 family Lycopene_cycl PF05834.12 EXF75650.1 - 0.033 13.2 0.0 0.056 12.5 0.0 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein Amino_oxidase PF01593.24 EXF75650.1 - 0.072 12.4 0.3 7.6 5.7 0.0 2.9 3 0 0 3 3 3 0 Flavin containing amine oxidoreductase DUF3533 PF12051.8 EXF75651.1 - 1.9e-119 399.0 11.5 2.2e-119 398.8 11.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3533) GWT1 PF06423.12 EXF75651.1 - 0.031 14.4 1.2 0.71 10.0 0.1 3.0 3 0 0 3 3 3 0 GWT1 Phage_holin_1 PF04531.13 EXF75651.1 - 0.047 14.2 0.3 0.16 12.6 0.3 1.9 1 0 0 1 1 1 0 Bacteriophage holin PDR_CDR PF06422.12 EXF75651.1 - 0.99 9.3 0.0 0.99 9.3 0.0 3.0 4 0 0 4 4 4 0 CDR ABC transporter MFS_1 PF07690.16 EXF75652.1 - 2.8e-34 118.6 32.8 2.8e-34 118.6 32.8 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily HET PF06985.11 EXF75652.1 - 1.1e-12 48.5 6.8 2.3e-10 41.0 1.6 2.5 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) MFS_2 PF13347.6 EXF75652.1 - 1.8e-05 23.5 5.8 2.7e-05 22.9 5.1 1.6 1 1 0 1 1 1 1 MFS/sugar transport protein Adeno_E3_15_3 PF03307.14 EXF75652.1 - 0.059 13.3 0.1 2 8.4 0.0 2.3 2 0 0 2 2 2 0 Adenovirus 15.3kD protein in E3 region DUF3533 PF12051.8 EXF75653.1 - 3.5e-96 322.4 7.5 4e-96 322.2 7.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3533) ABC_tran PF00005.27 EXF75654.1 - 1.2e-46 158.6 0.8 1.4e-24 87.2 0.0 2.7 2 0 0 2 2 2 2 ABC transporter ABC2_membrane_3 PF12698.7 EXF75654.1 - 4.2e-27 95.2 50.1 2.8e-17 62.9 34.9 2.8 2 1 1 3 3 3 2 ABC-2 family transporter protein AAA_21 PF13304.6 EXF75654.1 - 4.2e-21 76.0 6.8 9.9e-06 25.6 0.0 4.3 3 1 1 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EXF75654.1 - 2.1e-08 33.8 2.0 0.00041 20.0 0.3 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_23 PF13476.6 EXF75654.1 - 3.3e-07 31.0 2.8 0.008 16.7 0.3 2.5 2 0 0 2 2 2 2 AAA domain SMC_N PF02463.19 EXF75654.1 - 3.9e-07 29.7 4.7 0.15 11.5 0.2 4.2 4 0 0 4 4 4 3 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 EXF75654.1 - 9.2e-05 22.4 1.0 0.41 10.5 0.1 2.4 2 0 0 2 2 2 2 RsgA GTPase AAA_27 PF13514.6 EXF75654.1 - 0.00024 20.8 0.6 0.17 11.5 0.1 2.4 2 0 0 2 2 2 2 AAA domain AAA_15 PF13175.6 EXF75654.1 - 0.00065 19.5 0.4 0.82 9.3 0.1 3.2 3 0 0 3 3 3 1 AAA ATPase domain AAA_30 PF13604.6 EXF75654.1 - 0.00099 18.9 1.0 2.8 7.6 0.0 3.1 2 1 1 3 3 3 2 AAA domain AAA_16 PF13191.6 EXF75654.1 - 0.0015 18.9 0.5 3.1 8.2 0.0 3.0 3 0 0 3 3 3 2 AAA ATPase domain Zeta_toxin PF06414.12 EXF75654.1 - 0.04 13.2 0.2 7.9 5.7 0.0 2.5 2 0 0 2 2 2 0 Zeta toxin SRP54 PF00448.22 EXF75654.1 - 0.043 13.4 0.1 8.4 6.0 0.0 2.4 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_22 PF13401.6 EXF75654.1 - 0.045 14.0 0.5 14 6.0 0.1 3.1 2 1 0 2 2 2 0 AAA domain DUF87 PF01935.17 EXF75654.1 - 0.34 11.0 2.2 18 5.3 0.5 2.3 2 0 0 2 2 2 0 Helicase HerA, central domain AIG1 PF04548.16 EXF75654.1 - 0.97 8.7 2.4 3 7.1 0.5 2.3 2 0 0 2 2 2 0 AIG1 family RraA-like PF03737.15 EXF75655.1 - 2.5e-36 125.1 0.1 3.1e-36 124.8 0.1 1.1 1 0 0 1 1 1 1 Aldolase/RraA Amidohydro_2 PF04909.14 EXF75656.1 - 1.2e-12 48.2 0.5 1.4e-12 48.1 0.5 1.1 1 0 0 1 1 1 1 Amidohydrolase Mycobact_memb PF05423.13 EXF75656.1 - 0.039 13.9 0.0 0.067 13.1 0.0 1.3 1 0 0 1 1 1 0 Mycobacterium membrane protein Zn_clus PF00172.18 EXF75657.1 - 6e-09 35.9 7.8 1e-08 35.2 7.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EXF75657.1 - 0.0064 15.6 0.0 0.013 14.6 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain AAA_6 PF12774.7 EXF75657.1 - 0.13 11.2 0.0 3 6.7 0.0 2.1 2 0 0 2 2 2 0 Hydrolytic ATP binding site of dynein motor region Aconitase PF00330.20 EXF75658.1 - 3.9e-129 431.6 0.0 5.5e-129 431.1 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 EXF75658.1 - 1.3e-36 125.9 0.0 2.2e-36 125.1 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain DUF521 PF04412.13 EXF75658.1 - 0.052 12.3 0.0 0.099 11.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF521) MFS_1 PF07690.16 EXF75659.1 - 3.2e-34 118.4 21.3 3.2e-34 118.4 21.3 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily Acetyltransf_1 PF00583.25 EXF75659.1 - 0.048 13.9 0.0 0.098 12.9 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family FAD_binding_3 PF01494.19 EXF75660.1 - 2.6e-15 56.5 0.5 1.3e-14 54.2 0.5 1.9 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EXF75660.1 - 0.00017 20.9 0.0 0.0024 17.1 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EXF75660.1 - 0.00025 21.2 0.2 0.00082 19.6 0.2 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EXF75660.1 - 0.0014 18.3 3.3 0.0046 16.6 2.7 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase SE PF08491.10 EXF75660.1 - 0.0017 17.4 0.0 0.011 14.8 0.0 2.1 1 1 1 2 2 2 1 Squalene epoxidase FAD_binding_2 PF00890.24 EXF75660.1 - 0.0035 16.5 1.1 0.0068 15.5 1.1 1.4 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 EXF75660.1 - 0.0079 14.9 0.1 0.012 14.3 0.1 1.2 1 0 0 1 1 1 1 HI0933-like protein GIDA PF01134.22 EXF75660.1 - 0.086 11.9 0.8 0.13 11.4 0.8 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A Pyr_redox_3 PF13738.6 EXF75660.1 - 0.35 10.1 1.6 0.52 9.5 1.1 1.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Methyltransf_25 PF13649.6 EXF75661.1 - 1.2e-07 32.3 0.1 2.4e-07 31.3 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF75661.1 - 2.2e-07 31.4 0.1 4.6e-07 30.4 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF75661.1 - 1.2e-05 25.9 0.0 1.7e-05 25.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF75661.1 - 1.4e-05 24.9 0.0 2.1e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EXF75661.1 - 0.0041 17.0 0.0 0.0048 16.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain NodS PF05401.11 EXF75661.1 - 0.023 14.3 0.0 0.04 13.5 0.0 1.3 1 1 0 1 1 1 0 Nodulation protein S (NodS) DUF5121 PF17165.4 EXF75661.1 - 0.098 13.1 0.1 9.3 6.7 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5121) Oxidored_FMN PF00724.20 EXF75662.1 - 2.3e-90 303.4 0.0 2.6e-90 303.2 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family AP_endonuc_2 PF01261.24 EXF75662.1 - 0.009 15.5 0.0 2.1 7.7 0.0 2.3 1 1 1 2 2 2 2 Xylose isomerase-like TIM barrel DUF1848 PF08902.11 EXF75662.1 - 0.25 11.0 0.0 0.36 10.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1848) Abhydrolase_6 PF12697.7 EXF75663.1 - 8.7e-18 65.7 0.5 1e-17 65.5 0.5 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EXF75663.1 - 2.4e-09 37.2 0.0 4.7e-07 29.7 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EXF75663.1 - 7.3e-09 35.2 0.0 1.9e-08 33.9 0.0 1.6 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 EXF75663.1 - 0.0091 16.1 0.0 0.02 15.0 0.0 1.6 2 0 0 2 2 2 1 Thioesterase domain PGAP1 PF07819.13 EXF75663.1 - 0.046 13.4 0.0 0.1 12.3 0.0 1.5 1 0 0 1 1 1 0 PGAP1-like protein Ser_hydrolase PF06821.13 EXF75663.1 - 0.058 13.2 0.0 0.091 12.6 0.0 1.3 1 0 0 1 1 1 0 Serine hydrolase DUF676 PF05057.14 EXF75663.1 - 0.085 12.4 0.0 0.2 11.1 0.0 1.5 2 0 0 2 2 2 0 Putative serine esterase (DUF676) DUF3089 PF11288.8 EXF75663.1 - 0.15 11.6 0.0 0.4 10.2 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3089) HTH_16 PF12645.7 EXF75663.1 - 0.16 12.1 0.1 0.33 11.0 0.1 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain UPF0227 PF05728.12 EXF75663.1 - 0.16 11.9 0.0 0.38 10.7 0.0 1.6 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0227) GFO_IDH_MocA PF01408.22 EXF75664.1 - 2.5e-20 73.5 0.0 4.3e-20 72.7 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Semialdhyde_dh PF01118.24 EXF75664.1 - 9.2e-05 22.9 0.0 0.0002 21.8 0.0 1.6 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain GFO_IDH_MocA_C PF02894.17 EXF75664.1 - 0.063 13.3 0.0 0.13 12.2 0.0 1.6 1 0 0 1 1 1 0 Oxidoreductase family, C-terminal alpha/beta domain DUF1349 PF07081.11 EXF75665.1 - 2.6e-22 79.4 0.0 3.9e-22 78.8 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1349) Aminotran_3 PF00202.21 EXF75666.1 - 1.3e-81 274.4 0.0 1.5e-81 274.1 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III MFS_1 PF07690.16 EXF75667.1 - 2.6e-27 95.7 73.7 1.2e-20 73.8 40.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF3094 PF11293.8 EXF75667.1 - 3.3 7.5 5.4 16 5.3 0.7 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3094) HAD_2 PF13419.6 EXF75668.1 - 9.1e-17 61.7 0.0 1.2e-16 61.4 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EXF75668.1 - 3.1e-08 34.2 0.1 2.8e-07 31.0 0.1 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EXF75668.1 - 4.1e-05 23.6 0.0 9e-05 22.5 0.0 1.6 1 0 0 1 1 1 1 HAD-hyrolase-like HAD PF12710.7 EXF75668.1 - 0.021 15.2 0.0 0.032 14.6 0.0 1.3 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase DUF4974 PF16344.5 EXF75668.1 - 0.023 14.7 0.0 0.057 13.4 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4974) NIF PF03031.18 EXF75668.1 - 0.069 12.9 0.0 0.53 10.0 0.0 2.0 2 0 0 2 2 2 0 NLI interacting factor-like phosphatase GMC_oxred_N PF00732.19 EXF75669.1 - 3.8e-56 190.6 0.0 5.9e-56 190.0 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EXF75669.1 - 2.8e-30 105.7 0.3 5.6e-30 104.8 0.0 1.6 2 0 0 2 2 2 1 GMC oxidoreductase Pyr_redox_3 PF13738.6 EXF75669.1 - 3e-06 26.7 0.2 0.036 13.3 0.0 2.8 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EXF75669.1 - 0.00042 20.5 0.1 0.0012 19.0 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EXF75669.1 - 0.00051 19.7 0.1 0.00095 18.8 0.1 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EXF75669.1 - 0.001 18.2 0.2 0.033 13.3 0.2 2.3 2 0 0 2 2 2 1 FAD binding domain Lycopene_cycl PF05834.12 EXF75669.1 - 0.0023 17.0 0.1 0.0035 16.5 0.1 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein TrkA_N PF02254.18 EXF75669.1 - 0.0043 17.3 0.0 0.0089 16.3 0.0 1.5 1 0 0 1 1 1 1 TrkA-N domain Pyr_redox_2 PF07992.14 EXF75669.1 - 0.015 14.5 0.1 0.026 13.8 0.1 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EXF75669.1 - 0.026 13.8 0.8 0.046 13.0 0.1 1.7 2 0 0 2 2 2 0 FAD binding domain HI0933_like PF03486.14 EXF75669.1 - 0.044 12.5 0.0 0.085 11.5 0.0 1.4 1 0 0 1 1 1 0 HI0933-like protein Thi4 PF01946.17 EXF75669.1 - 0.071 12.3 0.0 0.15 11.3 0.0 1.5 1 0 0 1 1 1 0 Thi4 family Sugar_tr PF00083.24 EXF75671.1 - 1.5e-57 195.5 24.2 1.7e-57 195.3 24.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF75671.1 - 4.9e-13 48.7 35.9 4.9e-13 48.7 35.9 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EXF75671.1 - 6.3e-05 21.6 2.5 6.3e-05 21.6 2.5 1.7 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) zf-RNPHF PF08080.12 EXF75671.1 - 0.18 11.8 0.0 0.34 10.9 0.0 1.4 1 0 0 1 1 1 0 RNPHF zinc finger Glyco_hydro_43 PF04616.14 EXF75672.1 - 6.2e-63 212.8 0.0 8.4e-63 212.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 GH43_C2 PF17851.1 EXF75672.1 - 9.4e-15 54.9 0.0 1.4e-14 54.3 0.0 1.2 1 0 0 1 1 1 1 Beta xylosidase C-terminal Concanavalin A-like domain Abhydrolase_2 PF02230.16 EXF75673.1 - 5.6e-23 81.9 0.0 3.8e-22 79.2 0.0 2.0 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase FSH1 PF03959.13 EXF75673.1 - 0.0011 18.6 0.0 0.0023 17.6 0.0 1.5 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Peptidase_S9 PF00326.21 EXF75673.1 - 0.0024 17.4 0.0 0.0058 16.1 0.0 1.7 2 0 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_3 PF07859.13 EXF75673.1 - 0.026 14.4 0.1 2.9 7.7 0.1 2.4 1 1 1 2 2 2 0 alpha/beta hydrolase fold MFS_1 PF07690.16 EXF75675.1 - 1.1e-20 73.9 83.1 5.3e-16 58.5 47.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 EXF75675.1 - 4.3 5.5 11.6 0.24 9.7 3.6 2.3 2 1 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Peptidase_S10 PF00450.22 EXF75676.1 - 2.7e-80 270.8 0.0 3.4e-80 270.5 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase HIPIP PF01355.17 EXF75677.1 - 0.046 14.1 0.2 0.072 13.5 0.2 1.3 1 0 0 1 1 1 0 High potential iron-sulfur protein DUF3079 PF11278.8 EXF75677.1 - 0.073 12.9 0.5 0.073 12.9 0.5 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3079) Fructosamin_kin PF03881.14 EXF75678.1 - 1.5e-08 34.2 0.0 2.6e-08 33.4 0.0 1.3 1 0 0 1 1 1 1 Fructosamine kinase Dioxygenase_C PF00775.21 EXF75678.1 - 1.6e-05 24.4 0.0 3.3e-05 23.4 0.0 1.6 1 0 0 1 1 1 1 Dioxygenase APH PF01636.23 EXF75678.1 - 0.01 15.8 0.0 0.027 14.4 0.0 1.7 1 0 0 1 1 1 0 Phosphotransferase enzyme family NTP_transf_3 PF12804.7 EXF75679.1 - 6.7e-20 72.0 0.4 1.3e-19 71.1 0.4 1.5 1 1 0 1 1 1 1 MobA-like NTP transferase domain MGTL PF17059.5 EXF75679.1 - 0.018 14.8 2.0 0.92 9.4 0.1 2.7 2 0 0 2 2 2 0 MgtA leader peptide SLAC1 PF03595.17 EXF75680.1 - 1.9e-48 165.4 28.6 2.4e-48 165.1 28.6 1.0 1 0 0 1 1 1 1 Voltage-dependent anion channel F-box-like PF12937.7 EXF75681.1 - 0.0014 18.5 0.0 0.014 15.3 0.0 2.6 2 1 0 2 2 2 1 F-box-like Peptidase_S8 PF00082.22 EXF75682.1 - 8.4e-32 110.6 15.5 2.1e-31 109.3 15.5 1.5 1 1 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 EXF75682.1 - 0.0052 17.4 0.4 0.011 16.4 0.4 1.6 1 0 0 1 1 1 1 Peptidase inhibitor I9 Cyc-maltodext_C PF10438.9 EXF75682.1 - 0.06 13.4 0.8 0.17 12.0 0.1 2.1 2 0 0 2 2 2 0 Cyclo-malto-dextrinase C-terminal domain SQS_PSY PF00494.19 EXF75683.1 - 6.6e-36 124.1 0.0 1.2e-35 123.3 0.0 1.4 2 0 0 2 2 2 1 Squalene/phytoene synthase RmlD_sub_bind PF04321.17 EXF75684.1 - 1.8e-14 53.5 0.0 7.3e-14 51.5 0.0 1.8 1 1 0 1 1 1 1 RmlD substrate binding domain Epimerase PF01370.21 EXF75684.1 - 1.2e-11 44.5 0.0 2.4e-11 43.5 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EXF75684.1 - 0.002 17.3 0.0 0.0033 16.6 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 EXF75684.1 - 0.0087 15.5 0.0 0.15 11.4 0.0 2.3 2 1 1 3 3 3 1 GDP-mannose 4,6 dehydratase C2-set_2 PF08205.12 EXF75684.1 - 0.02 14.9 0.4 0.062 13.4 0.2 1.8 1 1 1 2 2 2 0 CD80-like C2-set immunoglobulin domain 3Beta_HSD PF01073.19 EXF75684.1 - 0.021 13.9 0.0 0.041 12.9 0.0 1.4 1 1 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family DnaJ-X PF14308.6 EXF75685.1 - 8.6e-78 260.6 2.1 8.6e-78 260.6 2.1 1.7 2 0 0 2 2 2 1 X-domain of DnaJ-containing DnaJ PF00226.31 EXF75685.1 - 9.8e-27 92.9 1.1 2.1e-26 91.8 1.1 1.6 1 0 0 1 1 1 1 DnaJ domain LtuB PF17455.2 EXF75685.1 - 1.7 9.3 5.4 0.28 11.8 1.0 2.0 2 0 0 2 2 2 0 Late transcription unit B Isochorismatase PF00857.20 EXF75686.1 - 7.8e-25 88.0 0.0 9.9e-25 87.7 0.0 1.1 1 0 0 1 1 1 1 Isochorismatase family DUF3883 PF13020.6 EXF75687.1 - 8.4e-05 22.5 0.0 0.00021 21.2 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3883) HATPase_c_3 PF13589.6 EXF75687.1 - 0.0045 16.8 0.0 0.012 15.5 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Spt5_N PF11942.8 EXF75688.1 - 7.9 7.5 16.1 1.6 9.8 3.7 2.8 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal Cyt-b5 PF00173.28 EXF75689.1 - 1.1e-15 57.5 0.0 1.5e-15 57.0 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain NIBRIN_BRCT_II PF16508.5 EXF75690.1 - 7.6e-37 126.3 0.0 2.9e-36 124.4 0.0 2.0 2 0 0 2 2 2 1 Second BRCT domain on Nijmegen syndrome breakage protein FHA PF00498.26 EXF75690.1 - 7.8e-09 35.8 0.1 1.5e-08 34.8 0.1 1.5 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 EXF75690.1 - 0.0064 16.8 0.0 0.087 13.1 0.0 2.5 1 1 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain RTT107_BRCT_5 PF16770.5 EXF75690.1 - 0.0086 15.9 0.0 0.02 14.8 0.0 1.5 1 0 0 1 1 1 1 Regulator of Ty1 transposition protein 107 BRCT domain Mannosyl_trans PF05007.13 EXF75691.1 - 2.9e-75 253.5 12.6 3.9e-75 253.1 12.6 1.2 1 0 0 1 1 1 1 Mannosyltransferase (PIG-M) PIG-U PF06728.13 EXF75691.1 - 4.6e-10 39.1 9.9 4.4e-09 35.9 9.9 2.3 1 1 0 1 1 1 1 GPI transamidase subunit PIG-U GT87 PF09594.10 EXF75691.1 - 8.4e-05 22.4 22.4 8.4e-05 22.4 22.4 2.3 2 1 0 2 2 2 1 Glycosyltransferase family 87 DUF3098 PF11297.8 EXF75691.1 - 0.5 10.0 3.9 4.1 7.1 0.1 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3098) Translin PF01997.16 EXF75692.1 - 2.1e-59 201.0 0.1 2.4e-59 200.7 0.1 1.0 1 0 0 1 1 1 1 Translin family FliJ PF02050.16 EXF75692.1 - 0.072 13.3 0.7 0.11 12.7 0.2 1.5 2 0 0 2 2 2 0 Flagellar FliJ protein NPV_P10 PF05531.12 EXF75692.1 - 0.085 13.3 0.1 0.51 10.9 0.0 2.1 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein AAA PF00004.29 EXF75693.1 - 0.19 12.1 0.6 0.95 9.9 0.6 2.2 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RTA1 PF04479.13 EXF75694.1 - 7.5e-65 218.4 10.6 1.2e-64 217.8 10.6 1.3 1 0 0 1 1 1 1 RTA1 like protein HisKA_7TM PF16927.5 EXF75694.1 - 1.9 8.5 21.6 7.1 6.6 21.9 1.8 1 1 0 1 1 1 0 N-terminal 7TM region of histidine kinase DUF4131 PF13567.6 EXF75694.1 - 6 6.5 16.0 0.23 11.1 3.1 3.1 1 1 2 3 3 3 0 Domain of unknown function (DUF4131) AAT PF03417.16 EXF75695.1 - 1.9e-25 89.9 0.0 2.3e-25 89.6 0.0 1.1 1 0 0 1 1 1 1 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase Tricorn_C1 PF14684.6 EXF75695.1 - 0.13 12.4 0.0 0.25 11.4 0.0 1.4 1 0 0 1 1 1 0 Tricorn protease C1 domain Sugar_tr PF00083.24 EXF75696.1 - 8.1e-76 255.7 22.3 1.1e-75 255.2 22.3 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter p450 PF00067.22 EXF75696.1 - 4e-65 220.4 0.0 1.2e-64 218.8 0.0 1.6 1 1 0 1 1 1 1 Cytochrome P450 MFS_1 PF07690.16 EXF75696.1 - 9.1e-24 84.0 26.8 1.3e-23 83.6 14.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily NmrA PF05368.13 EXF75697.1 - 2.2e-23 83.1 0.0 3e-23 82.6 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EXF75697.1 - 5.2e-09 36.3 0.3 1.1e-08 35.2 0.3 1.7 1 1 0 1 1 1 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 EXF75697.1 - 0.047 14.0 0.5 0.093 13.0 0.2 1.6 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain FAD_binding_4 PF01565.23 EXF75698.1 - 3.9e-25 88.2 0.3 6.3e-25 87.5 0.3 1.3 1 0 0 1 1 1 1 FAD binding domain adh_short_C2 PF13561.6 EXF75699.1 - 7.4e-46 156.6 1.0 1e-45 156.1 1.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF75699.1 - 3.6e-38 131.0 0.5 5e-38 130.5 0.5 1.2 1 0 0 1 1 1 1 short chain dehydrogenase DLH PF01738.18 EXF75699.1 - 3.2e-22 79.2 0.0 5.5e-22 78.4 0.0 1.3 1 0 0 1 1 1 1 Dienelactone hydrolase family KR PF08659.10 EXF75699.1 - 1.3e-06 28.5 0.8 2.1e-06 27.8 0.8 1.3 1 0 0 1 1 1 1 KR domain Abhydrolase_1 PF00561.20 EXF75699.1 - 0.029 14.0 0.0 0.045 13.4 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold 3HCDH_N PF02737.18 EXF75699.1 - 0.036 13.9 0.2 0.061 13.2 0.2 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Eno-Rase_NADH_b PF12242.8 EXF75699.1 - 0.063 13.1 0.1 0.29 10.9 0.1 2.0 2 0 0 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase EthD PF07110.11 EXF75700.1 - 1.6e-05 26.0 0.2 3.7e-05 24.8 0.2 1.6 1 1 0 1 1 1 1 EthD domain Glyco_hydro_43 PF04616.14 EXF75701.1 - 2.4e-57 194.5 7.7 3.1e-57 194.1 7.7 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 DUF1080 PF06439.11 EXF75701.1 - 1.3e-07 32.0 0.1 2.7e-07 30.9 0.1 1.5 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1080) AzlC PF03591.14 EXF75702.1 - 0.018 15.5 3.2 0.018 15.5 3.2 2.9 3 0 0 3 3 3 0 AzlC protein MmgE_PrpD PF03972.14 EXF75703.1 - 2.3e-110 369.1 0.2 2.9e-110 368.8 0.2 1.0 1 0 0 1 1 1 1 MmgE/PrpD family DUF2650 PF10853.8 EXF75704.1 - 7.4 6.4 9.5 0.48 10.2 3.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2650) Glyco_hydro_10 PF00331.20 EXF75705.1 - 1.7e-101 339.5 0.1 2e-101 339.3 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 10 CBM_1 PF00734.18 EXF75705.1 - 1.5e-12 47.3 9.7 1.5e-12 47.3 9.7 2.1 2 0 0 2 2 2 1 Fungal cellulose binding domain YqjK PF13997.6 EXF75706.1 - 0.15 12.3 0.2 0.15 12.3 0.2 2.5 3 0 0 3 3 3 0 YqjK-like protein TFIIA PF03153.13 EXF75706.1 - 0.56 10.2 6.3 0.77 9.7 6.3 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Glyco_hydro_12 PF01670.16 EXF75707.1 - 3.5e-21 76.2 8.1 4.8e-16 59.4 2.6 2.1 1 1 1 2 2 2 2 Glycosyl hydrolase family 12 Macoilin PF09726.9 EXF75708.1 - 2.7 6.4 8.4 2.9 6.3 8.4 1.1 1 0 0 1 1 1 0 Macoilin family TrkH PF02386.16 EXF75709.1 - 4e-99 332.3 8.3 6.2e-97 325.1 2.8 2.0 2 0 0 2 2 2 2 Cation transport protein DUF5345 PF17280.2 EXF75709.1 - 0.064 13.2 0.1 0.064 13.2 0.1 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5345) OTT_1508_deam PF14441.6 EXF75710.1 - 1.8e-19 69.5 0.2 6.4e-19 67.7 0.2 2.0 2 0 0 2 2 2 1 OTT_1508-like deaminase RecO_C PF02565.15 EXF75710.1 - 0.04 13.7 0.0 0.16 11.8 0.0 1.9 2 0 0 2 2 2 0 Recombination protein O C terminal SGBP_B_XBD PF18329.1 EXF75711.1 - 0.0011 18.9 0.1 0.0021 18.0 0.1 1.5 1 1 0 1 1 1 1 Surface glycan-binding protein B xyloglucan binding domain Exop_C PF18559.1 EXF75711.1 - 0.0088 15.9 0.0 0.01 15.7 0.0 1.3 1 0 0 1 1 1 1 Galactose-binding domain-like CIA30 PF08547.12 EXF75711.1 - 0.011 15.7 0.0 0.013 15.5 0.0 1.2 1 0 0 1 1 1 0 Complex I intermediate-associated protein 30 (CIA30) Peptidase_S15 PF02129.18 EXF75712.1 - 0.00095 18.8 0.1 0.0013 18.4 0.1 1.2 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) DLH PF01738.18 EXF75712.1 - 0.0011 18.5 0.0 0.0073 15.9 0.0 2.2 2 1 0 2 2 2 1 Dienelactone hydrolase family DUF1100 PF06500.11 EXF75712.1 - 0.0036 16.2 0.0 0.0052 15.6 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1100) AXE1 PF05448.12 EXF75712.1 - 0.056 12.1 0.0 0.16 10.7 0.0 1.7 1 1 1 2 2 2 0 Acetyl xylan esterase (AXE1) Hydrolase_4 PF12146.8 EXF75712.1 - 0.072 12.3 0.0 0.81 8.9 0.0 2.5 1 1 1 2 2 2 0 Serine aminopeptidase, S33 BAAT_C PF08840.11 EXF75712.1 - 0.075 12.9 0.0 0.26 11.2 0.0 1.9 2 0 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal Apolipoprotein PF01442.18 EXF75713.1 - 6.1e-05 23.0 12.3 0.0047 16.8 7.4 3.4 2 1 0 2 2 2 1 Apolipoprotein A1/A4/E domain Plasmodium_Vir PF05795.11 EXF75713.1 - 0.011 15.2 0.0 0.011 15.2 0.0 2.8 3 1 0 3 3 3 0 Plasmodium vivax Vir protein Senescence PF06911.12 EXF75713.1 - 0.34 11.2 5.4 5 7.4 0.0 3.5 1 1 1 3 3 3 0 Senescence-associated protein Phasin PF05597.11 EXF75713.1 - 0.54 10.3 23.4 2.1 8.3 2.4 5.0 2 1 2 5 5 5 0 Poly(hydroxyalcanoate) granule associated protein (phasin) DUF883 PF05957.13 EXF75713.1 - 0.61 10.7 18.4 37 5.0 2.4 5.8 3 1 3 6 6 6 0 Bacterial protein of unknown function (DUF883) CotJB PF12652.7 EXF75713.1 - 0.71 10.1 2.9 48 4.3 0.1 3.5 3 0 0 3 3 3 0 CotJB protein CarD_CdnL_TRCF PF02559.16 EXF75713.1 - 4.5 8.1 16.9 2.4 8.9 1.3 4.9 4 1 1 5 5 5 0 CarD-like/TRCF domain ApoLp-III PF07464.11 EXF75713.1 - 6.4 6.9 30.1 17 5.5 0.5 5.2 3 1 2 5 5 5 0 Apolipophorin-III precursor (apoLp-III) Lactamase_B PF00753.27 EXF75714.1 - 1.4e-22 80.6 1.6 2.3e-22 80.0 1.6 1.3 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EXF75714.1 - 1.1e-06 28.4 0.0 1.5e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain FMO-like PF00743.19 EXF75715.1 - 2.8e-13 49.2 0.0 3.1e-12 45.7 0.0 2.5 2 2 0 2 2 2 1 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.6 EXF75715.1 - 8.9e-09 35.5 0.0 4.1e-08 33.3 0.0 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EXF75715.1 - 9.6e-08 31.6 0.0 2.8e-05 23.5 0.0 2.3 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EXF75715.1 - 2.9e-05 23.4 0.0 0.07 12.2 0.0 3.9 3 1 0 4 4 4 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.6 EXF75715.1 - 0.00084 18.7 0.0 0.0055 16.0 0.0 2.2 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EXF75715.1 - 0.016 15.2 0.1 1.4 8.9 0.0 3.0 3 0 0 3 3 3 0 FAD-NAD(P)-binding FluMu_N PF17891.1 EXF75715.1 - 0.057 13.2 0.1 0.16 11.8 0.1 1.7 2 0 0 2 2 2 0 Mu-like prophage FluMu N-terminal domain SWI2_SNF2 PF18766.1 EXF75715.1 - 0.14 11.8 0.2 0.25 11.0 0.2 1.4 1 0 0 1 1 1 0 SWI2/SNF2 ATPase Zn_clus PF00172.18 EXF75716.1 - 2.8e-07 30.6 5.7 4.4e-07 29.9 5.7 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain UPF0506 PF11703.8 EXF75716.1 - 0.014 15.8 4.2 0.026 14.9 4.2 1.3 1 0 0 1 1 1 0 UPF0506 p450 PF00067.22 EXF75717.1 - 1.3e-59 202.2 0.0 1.5e-59 202.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 ketoacyl-synt PF00109.26 EXF75718.1 - 4.1e-77 259.2 0.0 8.5e-77 258.1 0.0 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain AMP-binding PF00501.28 EXF75718.1 - 6.6e-77 258.9 0.0 1.3e-76 258.0 0.0 1.4 1 0 0 1 1 1 1 AMP-binding enzyme KR PF08659.10 EXF75718.1 - 1.7e-54 184.5 0.0 3.8e-50 170.3 0.0 2.7 2 0 0 2 2 2 2 KR domain Condensation PF00668.20 EXF75718.1 - 4.7e-54 183.8 0.0 8.2e-54 183.0 0.0 1.3 1 0 0 1 1 1 1 Condensation domain Acyl_transf_1 PF00698.21 EXF75718.1 - 1.8e-49 169.0 0.2 4.6e-49 167.6 0.2 1.6 1 0 0 1 1 1 1 Acyl transferase domain PS-DH PF14765.6 EXF75718.1 - 4.7e-40 137.7 0.1 7.6e-40 137.0 0.1 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase NAD_binding_4 PF07993.12 EXF75718.1 - 3.2e-37 128.1 0.0 1.6e-36 125.8 0.0 2.0 2 0 0 2 2 2 1 Male sterility protein Ketoacyl-synt_C PF02801.22 EXF75718.1 - 1.1e-31 109.3 0.2 3e-31 107.9 0.2 1.8 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Methyltransf_12 PF08242.12 EXF75718.1 - 5.1e-19 68.9 0.0 1.6e-18 67.2 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain Epimerase PF01370.21 EXF75718.1 - 1.3e-17 64.1 0.0 4.6e-15 55.7 0.0 3.0 3 0 0 3 3 3 1 NAD dependent epimerase/dehydratase family KAsynt_C_assoc PF16197.5 EXF75718.1 - 1e-15 58.1 0.0 3.1e-15 56.6 0.0 1.9 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension PP-binding PF00550.25 EXF75718.1 - 2.2e-14 53.5 0.5 4.7e-09 36.5 0.1 2.8 2 0 0 2 2 2 2 Phosphopantetheine attachment site Methyltransf_25 PF13649.6 EXF75718.1 - 3.2e-14 53.4 0.0 1.6e-13 51.1 0.0 2.4 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EXF75718.1 - 3.9e-13 49.6 0.0 9.7e-13 48.3 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF75718.1 - 7.2e-13 49.0 0.0 2.3e-12 47.4 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain adh_short PF00106.25 EXF75718.1 - 5.7e-12 45.5 0.0 5.6e-09 35.7 0.0 2.9 3 0 0 3 3 3 2 short chain dehydrogenase 3Beta_HSD PF01073.19 EXF75718.1 - 3.2e-09 36.2 0.0 2.5e-08 33.3 0.0 2.2 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Methyltransf_31 PF13847.6 EXF75718.1 - 3.4e-09 36.7 0.0 7.9e-09 35.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EXF75718.1 - 2.4e-07 30.3 0.0 4.9e-07 29.3 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Thiolase_N PF00108.23 EXF75718.1 - 1.9e-05 24.2 0.0 8.5e-05 22.0 0.0 2.0 2 0 0 2 2 2 1 Thiolase, N-terminal domain NAD_binding_10 PF13460.6 EXF75718.1 - 0.00028 20.8 0.0 0.0011 19.0 0.0 2.1 1 0 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 EXF75718.1 - 0.00028 20.4 0.0 0.0041 16.6 0.0 2.2 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase Methyltransf_16 PF10294.9 EXF75718.1 - 0.00029 20.6 0.0 0.00066 19.5 0.0 1.5 1 0 0 1 1 1 1 Lysine methyltransferase MTS PF05175.14 EXF75718.1 - 0.0021 17.7 0.0 0.0048 16.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain DUF938 PF06080.12 EXF75718.1 - 0.022 14.5 0.0 0.056 13.2 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF938) Semialdhyde_dh PF01118.24 EXF75718.1 - 0.074 13.5 0.0 0.38 11.2 0.0 2.3 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain ACP_syn_III PF08545.10 EXF75718.1 - 0.08 12.8 2.1 0.4 10.6 0.1 3.0 3 0 0 3 3 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III RrnaAD PF00398.20 EXF75718.1 - 0.084 11.9 0.0 0.16 11.0 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Methyltransf_33 PF10017.9 EXF75718.1 - 0.089 11.9 0.0 0.18 10.9 0.0 1.4 1 0 0 1 1 1 0 Histidine-specific methyltransferase, SAM-dependent NmrA PF05368.13 EXF75718.1 - 0.098 12.2 0.0 1.5 8.3 0.0 2.5 2 0 0 2 2 2 0 NmrA-like family NNMT_PNMT_TEMT PF01234.17 EXF75718.1 - 0.15 11.3 0.0 0.68 9.1 0.0 2.0 2 0 0 2 2 2 0 NNMT/PNMT/TEMT family TRAM_LAG1_CLN8 PF03798.16 EXF75719.1 - 1e-34 120.1 14.7 1e-34 120.1 14.7 2.0 3 0 0 3 3 3 1 TLC domain TRAM1 PF08390.11 EXF75719.1 - 3.2e-26 90.8 0.8 6.2e-26 89.8 0.0 1.9 2 0 0 2 2 2 1 TRAM1-like protein TRAM_LAG1_CLN8 PF03798.16 EXF75720.1 - 1e-40 139.6 13.9 1.7e-40 138.9 13.9 1.4 1 0 0 1 1 1 1 TLC domain TRAM1 PF08390.11 EXF75720.1 - 7.5e-22 76.8 0.0 1.9e-21 75.4 0.0 1.7 1 0 0 1 1 1 1 TRAM1-like protein DoxX_3 PF13781.6 EXF75720.1 - 0.016 15.8 0.2 0.058 14.0 0.2 2.0 1 0 0 1 1 1 0 DoxX-like family Mito_carr PF00153.27 EXF75721.1 - 5.5e-42 141.6 7.2 5.9e-18 64.6 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein SnoaL PF07366.12 EXF75722.1 - 2.3e-26 92.1 0.3 2e-16 60.0 0.0 2.1 2 0 0 2 2 2 2 SnoaL-like polyketide cyclase SnoaL_2 PF12680.7 EXF75722.1 - 5.9e-09 36.5 0.0 0.0013 19.3 0.0 2.3 2 0 0 2 2 2 2 SnoaL-like domain DUF2666 PF10869.8 EXF75722.1 - 0.08 13.2 0.1 15 5.8 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2666) Glyco_hydro_61 PF03443.14 EXF75723.1 - 5.1e-57 193.1 0.0 6.1e-57 192.9 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 Pkinase PF00069.25 EXF75724.1 - 2.8e-23 82.6 0.0 3.7e-23 82.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF75724.1 - 1.5e-09 37.5 0.0 2.5e-09 36.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pox_ser-thr_kin PF05445.11 EXF75724.1 - 0.059 12.3 0.1 0.089 11.7 0.1 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Glyco_hydro_28 PF00295.17 EXF75726.1 - 2.6e-41 141.8 3.4 3.7e-41 141.2 3.4 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 Beta_helix PF13229.6 EXF75726.1 - 0.023 14.5 16.6 0.019 14.8 12.4 2.5 1 1 0 2 2 2 0 Right handed beta helix region Pectate_lyase PF03211.13 EXF75727.1 - 1.2e-79 266.6 9.0 1.5e-79 266.2 9.0 1.1 1 0 0 1 1 1 1 Pectate lyase IBR PF01485.21 EXF75728.1 - 1.1e-08 35.2 40.8 4.3e-05 23.6 6.0 3.6 3 0 0 3 3 3 2 IBR domain, a half RING-finger domain zf-RING_5 PF14634.6 EXF75728.1 - 0.0016 18.4 9.4 0.0016 18.4 9.4 4.2 4 1 0 4 4 4 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EXF75728.1 - 0.002 18.0 6.7 0.002 18.0 6.7 3.7 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EXF75728.1 - 0.0026 18.1 7.1 0.0026 18.1 7.1 3.7 2 1 1 3 3 3 1 Ring finger domain zf-RING_UBOX PF13445.6 EXF75728.1 - 0.016 15.2 9.1 0.016 15.2 9.1 3.1 3 0 0 3 3 3 0 RING-type zinc-finger adh_short PF00106.25 EXF75729.1 - 4.6e-54 182.8 0.3 5.7e-54 182.5 0.3 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF75729.1 - 1.7e-49 168.5 1.0 3.1e-49 167.6 1.0 1.4 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF75729.1 - 3e-12 46.8 0.2 5.2e-12 46.0 0.2 1.4 1 1 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EXF75729.1 - 0.012 14.7 0.1 0.017 14.3 0.1 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Epimerase PF01370.21 EXF75729.1 - 0.016 14.7 0.6 0.089 12.2 0.6 2.1 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family DUF1482 PF07358.11 EXF75729.1 - 0.061 13.3 0.1 0.14 12.1 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1482) PCEMA1 PF07418.11 EXF75729.1 - 0.13 11.7 0.2 0.96 8.9 0.0 2.2 2 1 1 3 3 3 0 Acidic phosphoprotein precursor PCEMA1 PMSR PF01625.21 EXF75730.1 - 1.2e-60 204.1 0.3 1.5e-60 203.8 0.3 1.0 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase Bax1-I PF01027.20 EXF75731.1 - 3.7e-37 128.2 9.9 6.1e-37 127.5 9.9 1.2 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 cNMPbd_u2 PF16643.5 EXF75733.1 - 2.1e-38 132.3 20.8 2.1e-38 132.3 20.8 1.9 2 0 0 2 2 2 1 Unstructured region on cNMP-binding protein cNMP_binding PF00027.29 EXF75733.1 - 1.4e-34 118.0 0.0 5.8e-18 64.7 0.0 2.6 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain LRR_6 PF13516.6 EXF75733.1 - 5.2e-09 35.5 5.2 0.17 12.0 0.0 6.4 6 0 0 6 6 6 3 Leucine Rich repeat LRR_4 PF12799.7 EXF75733.1 - 5.8e-08 32.9 3.2 0.022 15.2 0.0 5.3 5 2 2 7 7 7 3 Leucine Rich repeats (2 copies) F-box-like PF12937.7 EXF75733.1 - 4.8e-05 23.2 0.6 0.00021 21.1 0.0 2.3 2 0 0 2 2 2 1 F-box-like LRR_1 PF00560.33 EXF75733.1 - 0.0015 18.8 13.2 9.4 7.2 0.0 7.4 8 0 0 8 8 8 2 Leucine Rich Repeat F-box PF00646.33 EXF75733.1 - 0.0015 18.4 0.1 0.0015 18.4 0.1 2.9 3 0 0 3 3 3 1 F-box domain LRR_8 PF13855.6 EXF75733.1 - 0.0017 18.1 0.6 4.5 7.1 0.0 4.2 3 1 2 5 5 5 2 Leucine rich repeat HET PF06985.11 EXF75735.1 - 4.8e-13 49.7 5.1 8.8e-11 42.3 0.7 2.4 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) TERT_thumb PF17984.1 EXF75736.1 - 0.073 13.0 0.0 5.3 6.9 0.0 2.5 2 0 0 2 2 2 0 Telomerase reverse transcriptase thumb DNA binding domain NPP1 PF05630.11 EXF75737.1 - 1.2e-08 35.3 2.1 1.7e-08 34.8 0.8 1.7 1 1 1 2 2 2 1 Necrosis inducing protein (NPP1) DUF2235 PF09994.9 EXF75738.1 - 1e-84 284.3 0.0 2.3e-83 279.9 0.0 2.3 1 1 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) MFS_1 PF07690.16 EXF75739.1 - 2.7e-29 102.2 26.6 2.7e-29 102.2 26.6 1.6 1 1 1 2 2 2 2 Major Facilitator Superfamily ETRAMP PF09716.10 EXF75739.1 - 2.3 8.3 5.0 48 4.1 1.6 3.0 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) Glyco_hydro_125 PF06824.11 EXF75740.1 - 1.1e-179 597.7 0.0 1.3e-179 597.5 0.0 1.0 1 0 0 1 1 1 1 Metal-independent alpha-mannosidase (GH125) Herpes_LMP1 PF05297.11 EXF75740.1 - 3.7 6.7 5.4 5.8 6.0 5.4 1.3 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) Ank_2 PF12796.7 EXF75742.1 - 8.7e-50 167.2 0.1 1.2e-15 57.8 0.0 4.9 1 1 2 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.30 EXF75742.1 - 3.6e-49 163.1 6.2 0.00018 21.8 0.0 9.5 9 0 0 9 9 9 9 Ankyrin repeat Ank_4 PF13637.6 EXF75742.1 - 1e-46 156.7 1.3 1.2e-09 38.5 0.0 6.2 2 1 3 6 6 6 6 Ankyrin repeats (many copies) Ank_5 PF13857.6 EXF75742.1 - 2.8e-40 135.8 12.0 7.5e-09 35.7 0.0 7.4 2 1 6 8 8 8 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 EXF75742.1 - 4.2e-39 128.1 0.9 0.00069 19.9 0.0 9.5 9 0 0 9 9 9 7 Ankyrin repeat TFIIA PF03153.13 EXF75742.1 - 0.029 14.4 5.2 0.054 13.5 5.2 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit TPR_1 PF00515.28 EXF75743.1 - 2.8e-45 150.3 16.2 2.6e-07 30.2 0.1 9.1 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_2 PF07719.17 EXF75743.1 - 6.1e-37 122.8 15.8 7.5e-05 22.6 0.0 9.5 9 0 0 9 9 9 7 Tetratricopeptide repeat STI1 PF17830.1 EXF75743.1 - 4.8e-35 119.3 12.8 4.5e-19 68.1 1.6 3.0 3 0 0 3 3 2 2 STI1 domain TPR_11 PF13414.6 EXF75743.1 - 1.6e-24 85.3 11.4 0.00023 20.8 0.2 8.6 5 2 3 8 8 8 7 TPR repeat TPR_8 PF13181.6 EXF75743.1 - 1.7e-19 68.3 18.4 0.00029 20.8 0.4 8.2 8 0 0 8 8 7 5 Tetratricopeptide repeat TPR_16 PF13432.6 EXF75743.1 - 1.2e-16 61.0 1.3 0.0033 18.0 0.0 5.9 5 1 0 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.6 EXF75743.1 - 1.6e-16 60.4 12.2 1.8e-11 44.2 0.2 5.2 3 3 2 5 5 5 3 Tetratricopeptide repeat TPR_19 PF14559.6 EXF75743.1 - 1.8e-15 57.2 5.7 2.7e-05 24.6 0.0 6.2 5 2 1 7 7 6 3 Tetratricopeptide repeat TPR_14 PF13428.6 EXF75743.1 - 4.4e-14 52.0 5.2 1.4 9.9 0.0 8.1 6 2 3 9 9 8 4 Tetratricopeptide repeat TPR_17 PF13431.6 EXF75743.1 - 9.3e-14 50.7 3.3 0.063 13.7 0.2 7.6 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_7 PF13176.6 EXF75743.1 - 6.9e-13 47.6 7.6 0.0012 18.7 0.0 7.3 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_9 PF13371.6 EXF75743.1 - 5.7e-11 42.4 0.0 0.0009 19.3 0.0 4.6 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_10 PF13374.6 EXF75743.1 - 1.5e-07 31.0 8.9 0.029 14.3 0.0 6.0 5 1 1 6 6 5 2 Tetratricopeptide repeat TPR_6 PF13174.6 EXF75743.1 - 3.9e-05 24.0 12.7 1.2 9.9 0.1 7.2 8 0 0 8 8 6 2 Tetratricopeptide repeat TPR_MalT PF17874.1 EXF75743.1 - 0.00059 19.3 0.2 0.0035 16.8 0.0 2.3 3 0 0 3 3 3 1 MalT-like TPR region SHNi-TPR PF10516.9 EXF75743.1 - 0.00063 19.1 0.4 1.8 8.1 0.1 3.9 4 0 0 4 4 4 1 SHNi-TPR Fis1_TPR_C PF14853.6 EXF75743.1 - 0.012 15.7 1.0 22 5.2 0.1 5.3 5 0 0 5 5 5 0 Fis1 C-terminal tetratricopeptide repeat ANAPC3 PF12895.7 EXF75743.1 - 0.046 13.9 0.8 0.046 13.9 0.8 2.9 3 0 0 3 3 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_3 PF07720.12 EXF75743.1 - 0.064 13.3 4.5 0.28 11.2 0.0 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat RPN7 PF10602.9 EXF75743.1 - 0.079 12.7 4.5 0.32 10.7 0.3 3.4 3 2 0 3 3 2 0 26S proteasome subunit RPN7 DUF3658 PF12395.8 EXF75743.1 - 0.11 12.4 0.2 1 9.3 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function DUF5486 PF17588.2 EXF75743.1 - 0.2 11.5 5.6 0.82 9.6 1.6 2.7 2 0 0 2 2 2 0 Family of unknown function (DUF5486) DUF5113 PF17140.4 EXF75743.1 - 0.82 9.5 5.7 56 3.5 0.1 4.0 3 1 0 4 4 4 0 Domain of unknown function (DUF5113) MIT PF04212.18 EXF75743.1 - 1.3 9.2 20.5 0.66 10.1 0.8 6.6 6 2 0 6 6 6 0 MIT (microtubule interacting and transport) domain TPM_phosphatase PF04536.14 EXF75743.1 - 6.4 7.0 7.8 31 4.7 0.0 4.2 5 0 0 5 5 4 0 TPM domain Peptidase_C12 PF01088.21 EXF75744.1 - 1.1e-49 169.0 0.0 1.3e-49 168.9 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 Hemerythrin PF01814.23 EXF75745.1 - 1.7e-07 31.9 0.0 2.1e-07 31.6 0.0 1.2 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain Ctr PF04145.15 EXF75746.1 - 3.7e-40 138.0 0.2 4.8e-40 137.6 0.2 1.1 1 0 0 1 1 1 1 Ctr copper transporter family YfhO PF09586.10 EXF75746.1 - 8.9 4.4 8.1 15 3.7 8.1 1.2 1 0 0 1 1 1 0 Bacterial membrane protein YfhO TauD PF02668.16 EXF75747.1 - 1.8e-50 172.3 0.7 2.1e-50 172.0 0.7 1.0 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family HU-CCDC81_euk_2 PF18289.1 EXF75747.1 - 0.083 13.1 0.0 0.2 11.8 0.0 1.6 1 0 0 1 1 1 0 CCDC81 eukaryotic HU domain 2 Thioredoxin_16 PF18569.1 EXF75747.1 - 0.12 12.6 0.4 0.32 11.1 0.1 1.9 2 0 0 2 2 2 0 Thioredoxin-like domain Zeta_toxin PF06414.12 EXF75747.1 - 0.13 11.5 0.0 0.23 10.7 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin zf-C2H2_4 PF13894.6 EXF75748.1 - 0.0071 17.1 23.5 0.61 11.1 0.1 6.7 5 1 2 7 7 7 2 C2H2-type zinc finger zf-C2HE PF16278.5 EXF75748.1 - 0.14 12.6 0.2 0.14 12.6 0.2 2.9 3 0 0 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_jaz PF12171.8 EXF75748.1 - 0.19 12.1 10.8 1.9 8.9 0.1 4.5 4 1 1 5 5 5 0 Zinc-finger double-stranded RNA-binding zf_C2H2_6 PF18450.1 EXF75748.1 - 1.1 9.0 6.1 1.6 8.5 0.2 3.3 3 1 1 4 4 4 0 Zinc Finger domain zf-Di19 PF05605.12 EXF75748.1 - 1.7 9.0 11.7 4.8 7.6 3.1 4.0 2 1 2 4 4 4 0 Drought induced 19 protein (Di19), zinc-binding PyrI_C PF02748.15 EXF75748.1 - 9.9 6.2 9.6 1.3 9.0 0.6 3.2 2 1 1 3 3 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain Zn_clus PF00172.18 EXF75749.1 - 1.5e-06 28.2 8.8 3.1e-06 27.2 8.8 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.16 EXF75750.1 - 8.6e-34 117.0 26.1 8.6e-34 117.0 26.1 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily Jagunal PF07086.12 EXF75750.1 - 0.39 10.8 6.0 0.25 11.4 2.9 2.1 2 0 0 2 2 2 0 Jagunal, ER re-organisation during oogenesis AtuA PF07287.11 EXF75751.1 - 1.6e-126 421.7 0.0 2e-126 421.4 0.0 1.1 1 0 0 1 1 1 1 Acyclic terpene utilisation family protein AtuA Fungal_trans PF04082.18 EXF75752.1 - 8.7e-16 57.7 0.0 1.7e-15 56.8 0.0 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF75752.1 - 3e-09 36.8 12.3 5.6e-09 36.0 12.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SPX PF03105.19 EXF75752.1 - 0.013 15.4 0.0 0.018 15.0 0.0 1.4 1 0 0 1 1 1 0 SPX domain DivIC PF04977.15 EXF75752.1 - 0.044 13.5 2.4 0.088 12.6 2.4 1.5 1 0 0 1 1 1 0 Septum formation initiator ABC_tran_CTD PF16326.5 EXF75752.1 - 0.16 12.2 0.6 0.37 11.1 0.6 1.6 1 0 0 1 1 1 0 ABC transporter C-terminal domain DUF4250 PF14056.6 EXF75752.1 - 0.36 10.8 3.8 7.7 6.6 0.1 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4250) Peptidase_M28 PF04389.17 EXF75753.1 - 5.6e-38 130.6 0.0 8.2e-38 130.1 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 EXF75753.1 - 5.4e-10 39.2 0.1 1.2e-09 38.1 0.1 1.6 1 0 0 1 1 1 1 PA domain Peptidase_M20 PF01546.28 EXF75753.1 - 0.0035 17.1 0.0 0.0061 16.3 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Gly-rich_Ago1 PF12764.7 EXF75753.1 - 0.058 14.2 0.8 0.12 13.2 0.8 1.4 1 0 0 1 1 1 0 Glycine-rich region of argonaut Zip PF02535.22 EXF75754.1 - 2.2e-54 184.9 0.6 2.6e-54 184.7 0.6 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter MGC-24 PF05283.11 EXF75754.1 - 0.02 15.4 0.0 0.042 14.3 0.0 1.4 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin RNA_pol_Rpc34 PF05158.12 EXF75755.1 - 7.4e-101 337.9 0.0 9.8e-101 337.5 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpc34 subunit RPA_C PF08784.11 EXF75755.1 - 0.023 15.3 0.2 0.13 12.9 0.0 2.4 3 1 1 4 4 4 0 Replication protein A C terminal Pro_isomerase PF00160.21 EXF75756.1 - 4.6e-42 144.0 0.3 5.7e-42 143.7 0.3 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD ENTH PF01417.20 EXF75757.1 - 3.6e-46 156.3 0.1 5.4e-46 155.7 0.1 1.3 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.16 EXF75757.1 - 0.00065 18.8 0.0 0.00091 18.3 0.0 1.2 1 0 0 1 1 1 1 ANTH domain DUF5102 PF17104.5 EXF75757.1 - 0.089 12.8 3.9 1.7 8.6 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF5102) MARVEL PF01284.23 EXF75758.1 - 0.0092 16.0 9.9 0.015 15.3 9.9 1.3 1 0 0 1 1 1 1 Membrane-associating domain AIM3 PF17096.5 EXF75758.1 - 1.2 10.2 6.7 0.87 10.6 0.5 2.5 2 0 0 2 2 2 0 Altered inheritance of mitochondria protein 3 ERAP1_C PF11838.8 EXF75759.1 - 2.4e-87 293.4 0.0 1.2e-86 291.1 0.0 2.0 2 0 0 2 2 2 1 ERAP1-like C-terminal domain Peptidase_M1 PF01433.20 EXF75759.1 - 1.2e-79 266.9 4.0 1.7e-79 266.4 4.0 1.2 1 0 0 1 1 1 1 Peptidase family M1 domain Peptidase_M1_N PF17900.1 EXF75759.1 - 1.7e-49 168.5 1.2 2.8e-49 167.8 0.5 1.7 2 0 0 2 2 2 1 Peptidase M1 N-terminal domain DUF45 PF01863.17 EXF75759.1 - 0.035 14.1 0.3 0.29 11.1 0.3 2.3 2 1 0 2 2 2 0 Protein of unknown function DUF45 Tcp11 PF05794.13 EXF75760.1 - 1.7e-99 333.9 0.4 1.7e-99 333.9 0.4 2.5 3 0 0 3 3 3 1 T-complex protein 11 NTS PF15447.6 EXF75760.1 - 0.12 12.9 1.0 13 6.3 0.0 3.5 4 0 0 4 4 4 0 N-terminal segments of PfEMP1 ODAPH PF15848.5 EXF75760.1 - 2.8 8.5 5.3 21 5.6 0.1 3.3 3 0 0 3 3 3 0 Odontogenesis associated phosphoprotein MCM PF00493.23 EXF75761.1 - 3.5e-103 343.5 0.5 5.3e-103 342.9 0.5 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EXF75761.1 - 7.2e-39 132.5 0.5 1.3e-38 131.7 0.5 1.4 1 0 0 1 1 1 1 MCM OB domain MCM6_C PF18263.1 EXF75761.1 - 4.4e-31 107.3 0.2 9.6e-31 106.2 0.2 1.6 1 0 0 1 1 1 1 MCM6 C-terminal winged-helix domain MCM_N PF14551.6 EXF75761.1 - 2e-23 82.9 0.1 6.3e-23 81.3 0.1 1.9 1 0 0 1 1 1 1 MCM N-terminal domain MCM_lid PF17855.1 EXF75761.1 - 4.8e-23 81.4 0.1 2.7e-22 79.0 0.0 2.3 2 0 0 2 2 2 1 MCM AAA-lid domain Mg_chelatase PF01078.21 EXF75761.1 - 2.6e-07 30.2 0.0 7.6e-07 28.7 0.0 1.8 1 1 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 EXF75761.1 - 0.0016 18.3 0.0 0.0055 16.6 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EXF75761.1 - 0.0018 18.0 0.0 0.0035 17.1 0.0 1.4 1 0 0 1 1 1 1 Sigma-54 interaction domain RNase_H2_suC PF08615.11 EXF75762.1 - 3.5e-27 95.3 0.0 4.5e-27 94.9 0.0 1.1 1 0 0 1 1 1 1 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) CMAS PF02353.20 EXF75763.1 - 3.8e-74 249.4 0.0 9.8e-74 248.1 0.0 1.6 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_25 PF13649.6 EXF75763.1 - 1.8e-12 47.8 0.0 3.5e-12 46.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF75763.1 - 1.2e-11 45.1 0.0 2.3e-11 44.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EXF75763.1 - 2.5e-09 37.2 0.0 4.2e-09 36.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF75763.1 - 3.6e-09 36.6 0.0 7e-09 35.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF75763.1 - 9e-07 29.6 0.0 1.8e-06 28.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 EXF75763.1 - 0.0015 18.3 0.0 0.0029 17.4 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_18 PF12847.7 EXF75763.1 - 0.015 15.2 0.0 0.026 14.5 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_3 PF01596.17 EXF75763.1 - 0.088 12.0 0.0 0.17 11.0 0.0 1.5 1 0 0 1 1 1 0 O-methyltransferase ADH_zinc_N PF00107.26 EXF75763.1 - 0.15 12.0 0.0 0.28 11.2 0.0 1.4 1 0 0 1 1 1 0 Zinc-binding dehydrogenase RrnaAD PF00398.20 EXF75763.1 - 0.21 10.6 0.0 0.37 9.8 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase RNase_T PF00929.24 EXF75764.1 - 1.2e-14 55.2 0.0 6e-14 52.9 0.0 2.0 1 1 0 1 1 1 1 Exonuclease DNA_pol_A_exo1 PF01612.20 EXF75764.1 - 0.0027 17.4 0.0 0.0062 16.3 0.0 1.6 1 1 0 1 1 1 1 3'-5' exonuclease RNA_pol_Rpc4 PF05132.14 EXF75764.1 - 2 8.8 8.5 3.6 8.0 8.5 1.4 1 0 0 1 1 1 0 RNA polymerase III RPC4 MOZ_SAS PF01853.18 EXF75765.1 - 1.3e-80 269.2 0.1 2e-80 268.7 0.1 1.3 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 EXF75765.1 - 4.1e-22 77.5 1.0 7.5e-22 76.7 1.0 1.5 1 0 0 1 1 1 1 MYST family zinc finger domain Tudor-knot PF11717.8 EXF75765.1 - 2.9e-16 59.1 0.0 1.1e-15 57.2 0.0 2.0 2 0 0 2 2 2 1 RNA binding activity-knot of a chromodomain Acetyltransf_7 PF13508.7 EXF75765.1 - 0.00022 21.6 0.0 0.00045 20.6 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EXF75765.1 - 0.0084 16.3 0.0 0.019 15.2 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Aminotran_1_2 PF00155.21 EXF75766.1 - 8.6e-13 48.2 0.0 1.6e-12 47.3 0.0 1.6 1 1 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.7 EXF75766.1 - 1.6e-05 23.9 0.0 5.1e-05 22.3 0.0 1.7 1 1 0 1 1 1 1 Alanine-glyoxylate amino-transferase FeoB_C PF07664.12 EXF75767.1 - 0.69 9.6 2.8 1.2 8.9 0.5 2.3 2 0 0 2 2 2 0 Ferrous iron transport protein B C terminus DUF3340 PF11818.8 EXF75768.1 - 0.033 14.3 2.2 0.065 13.4 2.2 1.4 1 0 0 1 1 1 0 C-terminal domain of tail specific protease (DUF3340) F1F0-ATPsyn_F PF10791.9 EXF75769.1 - 2.3e-41 140.2 0.1 2.6e-41 140.0 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial F1-F0 ATP synthase subunit F of fungi WRW PF10206.9 EXF75769.1 - 0.029 14.7 0.0 0.033 14.6 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial F1F0-ATP synthase, subunit f ETC_C1_NDUFA4 PF04800.12 EXF75770.1 - 3.4e-37 126.6 2.3 5.3e-37 126.0 2.3 1.3 1 0 0 1 1 1 1 ETC complex I subunit conserved region Copper-bind PF00127.20 EXF75770.1 - 0.036 14.5 0.0 0.076 13.5 0.0 1.5 1 1 0 1 1 1 0 Copper binding proteins, plastocyanin/azurin family CLTH PF10607.9 EXF75771.1 - 1.6e-31 109.2 0.0 2.7e-31 108.5 0.0 1.3 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.11 EXF75771.1 - 4.6e-09 35.9 0.0 1.1e-08 34.8 0.0 1.7 1 0 0 1 1 1 1 LisH Ribosomal_S8 PF00410.19 EXF75771.1 - 0.12 12.3 0.2 0.24 11.4 0.1 1.5 2 0 0 2 2 2 0 Ribosomal protein S8 PRK PF00485.18 EXF75772.1 - 7.8e-49 166.1 0.0 1.2e-28 100.2 0.2 2.3 1 1 1 2 2 2 2 Phosphoribulokinase / Uridine kinase family UPRTase PF14681.6 EXF75772.1 - 5.1e-42 143.7 0.0 7.6e-42 143.1 0.0 1.2 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase AAA_18 PF13238.6 EXF75772.1 - 2e-06 28.4 0.0 4.8e-06 27.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 EXF75772.1 - 1e-05 26.0 0.2 0.00011 22.6 0.0 2.5 2 1 0 2 2 2 1 AAA domain CPT PF07931.12 EXF75772.1 - 4.9e-05 23.2 0.0 0.0001 22.2 0.0 1.5 1 0 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein AAA_33 PF13671.6 EXF75772.1 - 6.2e-05 23.2 0.0 0.00058 20.0 0.0 2.2 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.27 EXF75772.1 - 0.0019 18.7 0.2 0.009 16.5 0.1 1.9 2 0 0 2 2 2 1 ABC transporter Zeta_toxin PF06414.12 EXF75772.1 - 0.0056 16.0 0.0 0.014 14.7 0.0 1.6 1 0 0 1 1 1 1 Zeta toxin AAA_29 PF13555.6 EXF75772.1 - 0.019 14.7 0.0 0.051 13.3 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain NB-ARC PF00931.22 EXF75772.1 - 0.027 13.6 0.0 0.053 12.7 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain DUF87 PF01935.17 EXF75772.1 - 0.079 13.0 0.3 0.22 11.6 0.3 1.7 1 1 0 1 1 1 0 Helicase HerA, central domain Cytidylate_kin PF02224.18 EXF75772.1 - 0.1 12.3 0.0 0.28 10.9 0.0 1.7 2 0 0 2 2 2 0 Cytidylate kinase NTPase_1 PF03266.15 EXF75772.1 - 0.15 11.9 0.0 0.97 9.3 0.0 2.1 2 0 0 2 2 2 0 NTPase dNK PF01712.19 EXF75772.1 - 0.18 11.7 0.0 7.9 6.3 0.0 2.2 2 0 0 2 2 2 0 Deoxynucleoside kinase Pyr_redox_2 PF07992.14 EXF75773.1 - 2.8e-42 145.0 0.0 4e-42 144.4 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EXF75773.1 - 2.4e-15 56.8 0.0 2e-10 41.1 0.0 3.9 4 0 0 4 4 4 2 Pyridine nucleotide-disulphide oxidoreductase EF-hand_1 PF00036.32 EXF75773.1 - 6.5e-06 25.3 0.2 1.4e-05 24.3 0.2 1.6 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 EXF75773.1 - 7.6e-05 22.3 0.4 0.00025 20.7 0.4 1.9 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.6 EXF75773.1 - 0.00063 20.1 0.1 0.0015 19.0 0.1 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 EXF75773.1 - 0.00088 18.7 0.8 0.002 17.5 0.8 1.6 1 0 0 1 1 1 1 EF hand Flavin_Reduct PF01613.18 EXF75773.1 - 0.028 14.5 0.0 0.048 13.7 0.0 1.3 1 0 0 1 1 1 0 Flavin reductase like domain Pyr_redox_3 PF13738.6 EXF75773.1 - 0.1 11.9 0.0 0.82 8.9 0.0 2.2 2 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NIR_SIR PF01077.22 EXF75774.1 - 3.7e-55 185.8 0.1 2.1e-49 167.1 0.1 2.6 2 0 0 2 2 2 2 Nitrite and sulphite reductase 4Fe-4S domain Flavodoxin_1 PF00258.25 EXF75774.1 - 2.4e-31 108.8 0.0 5.8e-31 107.6 0.0 1.7 1 0 0 1 1 1 1 Flavodoxin NIR_SIR_ferr PF03460.17 EXF75774.1 - 7e-31 105.9 0.0 1.4e-15 56.9 0.0 2.7 2 0 0 2 2 2 2 Nitrite/Sulfite reductase ferredoxin-like half domain POR_N PF01855.19 EXF75774.1 - 9.6e-09 35.3 0.1 2.2e-08 34.2 0.1 1.5 1 0 0 1 1 1 1 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg PFOR_II PF17147.4 EXF75774.1 - 5.2e-06 26.7 0.0 1.3e-05 25.4 0.0 1.7 1 0 0 1 1 1 1 Pyruvate:ferredoxin oxidoreductase core domain II RHH_7 PF16777.5 EXF75774.1 - 0.09 13.2 0.1 0.38 11.2 0.0 2.1 2 0 0 2 2 2 0 Transcriptional regulator, RHH-like, CopG Kei1 PF08552.11 EXF75775.1 - 2.2e-61 207.1 2.5 2.7e-61 206.8 2.5 1.1 1 0 0 1 1 1 1 Inositolphosphorylceramide synthase subunit Kei1 SPC12 PF06645.13 EXF75775.1 - 3.6 7.7 9.1 0.11 12.6 2.4 1.9 2 1 0 2 2 2 0 Microsomal signal peptidase 12 kDa subunit (SPC12) Ras PF00071.22 EXF75776.1 - 5.1e-57 192.0 0.6 6.7e-57 191.6 0.6 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EXF75776.1 - 1.3e-37 128.7 0.1 2.2e-37 128.0 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EXF75776.1 - 7.4e-17 61.3 0.2 1e-16 60.9 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EXF75776.1 - 7.7e-07 28.8 0.1 5.4e-06 26.1 0.1 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EXF75776.1 - 1.8e-05 24.8 0.0 4.1e-05 23.6 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 EXF75776.1 - 3.1e-05 23.5 0.1 5.3e-05 22.7 0.1 1.4 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 EXF75776.1 - 4.3e-05 23.0 0.4 5.6e-05 22.6 0.4 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 EXF75776.1 - 0.00013 21.9 0.1 0.079 12.9 0.1 2.2 2 0 0 2 2 2 2 RsgA GTPase ATP_bind_1 PF03029.17 EXF75776.1 - 0.012 15.4 0.2 0.031 14.0 0.0 1.7 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein ATPase_2 PF01637.18 EXF75776.1 - 0.017 15.1 0.0 0.033 14.1 0.0 1.3 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea FlgH PF02107.16 EXF75776.1 - 0.038 13.6 0.8 0.053 13.1 0.8 1.2 1 0 0 1 1 1 0 Flagellar L-ring protein TIR_2 PF13676.6 EXF75776.1 - 0.057 14.0 0.1 0.11 13.1 0.1 1.4 1 0 0 1 1 1 0 TIR domain TetR_C_16 PF17920.1 EXF75776.1 - 0.062 13.5 0.0 0.94 9.7 0.0 2.1 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain AAA_28 PF13521.6 EXF75776.1 - 0.082 13.1 0.0 2.4 8.4 0.0 2.2 1 1 0 1 1 1 0 AAA domain Nop53 PF07767.11 EXF75777.1 - 9.5e-107 357.8 26.2 1.2e-106 357.5 26.2 1.1 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) Fungal_trans PF04082.18 EXF75778.1 - 1.6e-30 106.1 12.4 4.3e-22 78.4 0.8 3.0 2 1 0 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF75778.1 - 5.3e-06 26.5 8.8 1.8e-05 24.7 8.8 1.9 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain HRI1 PF16815.5 EXF75779.1 - 1.8e-29 103.1 0.1 2.2e-29 102.8 0.1 1.0 1 0 0 1 1 1 1 Protein HRI1 AhpC-TSA_2 PF13911.6 EXF75780.1 - 2.2e-05 24.5 0.0 4e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme PAP_assoc PF03828.19 EXF75781.1 - 1.9e-17 63.2 0.1 4.8e-17 61.9 0.1 1.8 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 EXF75781.1 - 3.4e-05 24.0 0.0 6.4e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 Nucleotidyltransferase domain adh_short PF00106.25 EXF75783.1 - 2.9e-45 154.2 2.9 3.7e-45 153.8 2.9 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF75783.1 - 1.3e-40 139.4 1.6 1.6e-40 139.1 1.6 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF75783.1 - 6.6e-09 35.9 0.4 1.2e-08 35.0 0.2 1.6 2 0 0 2 2 2 1 KR domain Polysacc_synt_2 PF02719.15 EXF75783.1 - 0.0014 17.8 0.2 0.002 17.3 0.2 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein 3HCDH_N PF02737.18 EXF75783.1 - 0.0032 17.4 0.4 0.0053 16.7 0.4 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Epimerase PF01370.21 EXF75783.1 - 0.032 13.7 0.1 0.038 13.5 0.1 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family WCCH PF03716.14 EXF75784.1 - 0.025 14.2 0.1 0.025 14.2 0.1 3.9 4 0 0 4 4 4 0 WCCH motif DUF3405 PF11885.8 EXF75785.1 - 1.9e-230 765.9 5.6 2.3e-230 765.6 5.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3405) EMP24_GP25L PF01105.24 EXF75786.1 - 4.7e-46 157.0 0.0 5.4e-46 156.8 0.0 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Dioxygenase_C PF00775.21 EXF75786.1 - 0.083 12.3 0.0 0.12 11.8 0.0 1.2 1 0 0 1 1 1 0 Dioxygenase Arf PF00025.21 EXF75787.1 - 2.6e-80 268.0 0.3 3e-80 267.8 0.3 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EXF75787.1 - 1.7e-14 54.1 0.0 2.3e-14 53.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EXF75787.1 - 2e-14 53.4 0.0 2.5e-14 53.1 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 EXF75787.1 - 2.6e-13 49.9 1.5 2e-09 37.1 0.5 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 EXF75787.1 - 3.4e-13 49.5 0.0 3.8e-13 49.4 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 EXF75787.1 - 1.2e-10 41.1 0.0 1.6e-10 40.7 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EXF75787.1 - 2.9e-06 27.3 0.0 4.5e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.18 EXF75787.1 - 0.0095 15.3 1.0 0.028 13.7 1.0 1.8 1 1 0 1 1 1 1 6-phosphofructo-2-kinase AAA_2 PF07724.14 EXF75788.1 - 3.9e-44 150.8 0.0 4.3e-43 147.4 0.0 2.3 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 EXF75788.1 - 2.6e-35 120.5 2.2 2.6e-35 120.5 2.2 2.6 1 1 1 2 2 2 1 AAA lid domain ClpB_D2-small PF10431.9 EXF75788.1 - 6e-24 83.9 0.2 1.9e-23 82.3 0.2 2.0 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA PF00004.29 EXF75788.1 - 2.5e-18 66.8 0.1 1.9e-09 38.0 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EXF75788.1 - 1.3e-11 44.6 0.0 1.9e-08 34.4 0.0 3.0 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EXF75788.1 - 6.6e-09 36.4 4.8 0.00092 19.6 0.6 4.1 2 2 1 3 3 3 2 AAA ATPase domain Sigma54_activat PF00158.26 EXF75788.1 - 8.1e-07 28.9 0.2 0.00068 19.4 0.0 2.4 2 0 0 2 2 2 1 Sigma-54 interaction domain TniB PF05621.11 EXF75788.1 - 2.6e-06 27.0 0.1 0.0011 18.4 0.1 3.5 3 1 0 3 3 2 1 Bacterial TniB protein AAA_22 PF13401.6 EXF75788.1 - 3.5e-06 27.3 3.1 0.063 13.6 0.1 3.5 3 2 0 3 3 2 2 AAA domain NACHT PF05729.12 EXF75788.1 - 2e-05 24.6 0.0 0.091 12.7 0.0 2.6 2 0 0 2 2 2 2 NACHT domain ATPase_2 PF01637.18 EXF75788.1 - 7.1e-05 22.8 7.5 0.8 9.6 0.1 4.4 3 2 0 4 4 4 2 ATPase domain predominantly from Archaea AAA_14 PF13173.6 EXF75788.1 - 9.1e-05 22.5 0.0 0.47 10.5 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_7 PF12775.7 EXF75788.1 - 0.00033 20.2 0.0 0.82 9.2 0.0 2.4 2 0 0 2 2 2 2 P-loop containing dynein motor region IstB_IS21 PF01695.17 EXF75788.1 - 0.00043 20.1 0.3 0.5 10.1 0.0 2.7 2 1 0 2 2 2 2 IstB-like ATP binding protein AAA_18 PF13238.6 EXF75788.1 - 0.00059 20.4 0.5 0.31 11.6 0.0 3.1 3 0 0 3 3 2 1 AAA domain ABC_tran PF00005.27 EXF75788.1 - 0.00077 20.0 1.4 0.32 11.5 0.0 3.4 3 0 0 3 3 3 1 ABC transporter AAA_24 PF13479.6 EXF75788.1 - 0.00081 19.2 0.9 1.2 8.8 0.0 3.1 3 0 0 3 3 3 1 AAA domain AAA_33 PF13671.6 EXF75788.1 - 0.0053 16.9 0.0 2.4 8.3 0.0 2.7 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 EXF75788.1 - 0.0063 16.9 0.0 1.1 9.6 0.0 3.0 2 1 0 2 2 2 1 RNA helicase RsgA_GTPase PF03193.16 EXF75788.1 - 0.0079 16.1 0.0 1.5 8.7 0.0 2.7 2 0 0 2 2 2 1 RsgA GTPase AAA_23 PF13476.6 EXF75788.1 - 0.0093 16.5 8.7 2.5 8.6 4.4 3.3 3 0 0 3 3 3 1 AAA domain AAA_30 PF13604.6 EXF75788.1 - 0.0094 15.7 0.1 0.39 10.4 0.0 3.1 3 0 0 3 3 3 1 AAA domain PhoH PF02562.16 EXF75788.1 - 0.014 14.9 0.1 0.31 10.5 0.0 2.4 2 0 0 2 2 2 0 PhoH-like protein AAA_28 PF13521.6 EXF75788.1 - 0.018 15.3 0.7 14 5.9 0.0 3.5 3 1 0 3 3 3 0 AAA domain AAA_25 PF13481.6 EXF75788.1 - 0.019 14.5 0.2 0.33 10.5 0.0 2.7 2 0 0 2 2 2 0 AAA domain ResIII PF04851.15 EXF75788.1 - 0.023 14.7 0.2 12 5.9 0.0 3.4 2 1 0 3 3 3 0 Type III restriction enzyme, res subunit SRP54 PF00448.22 EXF75788.1 - 0.028 14.1 0.1 0.66 9.6 0.0 2.4 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain Roc PF08477.13 EXF75788.1 - 0.036 14.3 0.1 3.5 7.9 0.0 2.5 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Mg_chelatase PF01078.21 EXF75788.1 - 0.04 13.3 0.1 2.7 7.3 0.0 3.0 2 1 0 2 2 2 0 Magnesium chelatase, subunit ChlI PduV-EutP PF10662.9 EXF75788.1 - 0.045 13.5 0.0 0.91 9.3 0.0 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation PIF1 PF05970.14 EXF75788.1 - 0.088 12.0 0.0 5.9 5.9 0.0 2.7 3 0 0 3 3 3 0 PIF1-like helicase TsaE PF02367.17 EXF75788.1 - 0.096 12.7 0.1 10 6.1 0.0 2.7 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE UvrD-helicase PF00580.21 EXF75788.1 - 0.11 11.9 3.5 0.25 10.8 0.1 2.2 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain DUF4407 PF14362.6 EXF75788.1 - 0.14 11.5 3.3 0.22 10.9 3.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) AAA_21 PF13304.6 EXF75788.1 - 0.15 11.8 0.3 2.5 7.8 0.0 2.9 2 1 1 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system ATP_bind_1 PF03029.17 EXF75788.1 - 0.17 11.7 0.1 2.9 7.6 0.0 2.4 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_19 PF13245.6 EXF75788.1 - 0.25 11.7 3.2 1.3 9.4 0.3 3.1 2 2 1 3 3 3 0 AAA domain Zw10 PF06248.13 EXF75788.1 - 0.26 9.8 1.4 0.39 9.2 1.4 1.2 1 0 0 1 1 1 0 Centromere/kinetochore Zw10 OEP PF02321.18 EXF75788.1 - 0.66 9.8 5.4 2.1 8.1 5.4 1.8 1 0 0 1 1 1 0 Outer membrane efflux protein Seryl_tRNA_N PF02403.22 EXF75788.1 - 0.96 9.7 15.4 0.55 10.5 9.3 3.2 3 1 0 3 3 1 0 Seryl-tRNA synthetase N-terminal domain UPF0242 PF06785.11 EXF75788.1 - 1.9 8.6 9.6 4.5 7.3 9.6 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Herpes_UL14 PF03580.14 EXF75788.1 - 2.3 8.5 7.7 6 7.1 7.7 1.7 1 0 0 1 1 1 0 Herpesvirus UL14-like protein DUF16 PF01519.16 EXF75788.1 - 5.2 7.6 7.0 85 3.7 4.7 3.3 3 1 0 3 3 2 0 Protein of unknown function DUF16 ABC_tran_CTD PF16326.5 EXF75788.1 - 5.3 7.4 19.0 0.27 11.5 9.3 3.3 3 1 1 4 4 2 0 ABC transporter C-terminal domain PKcGMP_CC PF16808.5 EXF75788.1 - 9 6.2 9.9 7.4 6.5 1.1 3.0 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Ribosomal_L6e PF01159.19 EXF75789.1 - 1e-39 135.5 0.3 1.8e-39 134.7 0.3 1.4 1 0 0 1 1 1 1 Ribosomal protein L6e Peptidase_M49 PF03571.15 EXF75790.1 - 9.1e-249 826.4 0.0 1.1e-248 826.2 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M49 TetR_C_23 PF17931.1 EXF75790.1 - 0.079 13.1 0.2 0.83 9.8 0.0 2.3 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain 2C_adapt PF08793.10 EXF75790.1 - 0.17 12.1 0.3 0.43 10.8 0.3 1.6 1 0 0 1 1 1 0 2-cysteine adaptor domain SKI PF01202.22 EXF75791.1 - 1.9e-11 44.4 0.0 2.4e-11 44.0 0.0 1.1 1 0 0 1 1 1 1 Shikimate kinase AAA_33 PF13671.6 EXF75791.1 - 3e-09 37.2 0.0 4.6e-09 36.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EXF75791.1 - 1.2e-08 35.6 0.0 4.2e-08 33.8 0.0 2.0 1 1 0 1 1 1 1 AAA domain Rad17 PF03215.15 EXF75791.1 - 1.2e-05 25.4 0.0 2.1e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 Rad17 P-loop domain Cytidylate_kin PF02224.18 EXF75791.1 - 1.8e-05 24.6 0.0 4.6e-05 23.3 0.0 1.6 2 0 0 2 2 2 1 Cytidylate kinase AAA_17 PF13207.6 EXF75791.1 - 3.4e-05 24.3 0.0 8.8e-05 22.9 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 EXF75791.1 - 7.2e-05 23.2 0.1 0.00021 21.7 0.0 1.8 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EXF75791.1 - 0.00019 21.9 0.0 0.00034 21.0 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EXF75791.1 - 0.0007 19.9 0.0 0.002 18.4 0.0 1.6 1 1 0 1 1 1 1 AAA domain NACHT PF05729.12 EXF75791.1 - 0.0015 18.5 0.0 0.0027 17.6 0.0 1.4 1 0 0 1 1 1 1 NACHT domain PRK PF00485.18 EXF75791.1 - 0.0018 18.1 0.0 0.0033 17.2 0.0 1.4 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family Thymidylate_kin PF02223.17 EXF75791.1 - 0.002 17.9 0.0 1 9.0 0.0 2.2 2 0 0 2 2 2 2 Thymidylate kinase dNK PF01712.19 EXF75791.1 - 0.002 18.0 0.0 0.18 11.7 0.0 2.2 2 0 0 2 2 2 1 Deoxynucleoside kinase CoaE PF01121.20 EXF75791.1 - 0.0021 17.7 0.0 0.017 14.8 0.0 2.2 2 0 0 2 2 2 1 Dephospho-CoA kinase AAA_28 PF13521.6 EXF75791.1 - 0.0026 18.0 0.0 0.01 16.1 0.0 1.8 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 EXF75791.1 - 0.0028 18.0 0.0 0.005 17.2 0.0 1.4 1 0 0 1 1 1 1 RNA helicase AAA_5 PF07728.14 EXF75791.1 - 0.003 17.6 0.0 0.0056 16.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) ATPase_2 PF01637.18 EXF75791.1 - 0.011 15.6 0.1 0.053 13.4 0.0 1.9 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea ABC_tran PF00005.27 EXF75791.1 - 0.012 16.2 0.0 0.021 15.3 0.0 1.5 1 0 0 1 1 1 0 ABC transporter Cytidylate_kin2 PF13189.6 EXF75791.1 - 0.014 15.5 0.1 0.078 13.1 0.0 2.0 2 0 0 2 2 2 0 Cytidylate kinase-like family AAA_30 PF13604.6 EXF75791.1 - 0.022 14.5 0.0 0.044 13.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 EXF75791.1 - 0.028 13.8 0.0 0.064 12.6 0.0 1.6 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_14 PF13173.6 EXF75791.1 - 0.03 14.4 0.0 0.082 12.9 0.0 1.7 2 0 0 2 2 2 0 AAA domain APS_kinase PF01583.20 EXF75791.1 - 0.03 14.2 0.0 0.044 13.7 0.0 1.3 1 0 0 1 1 1 0 Adenylylsulphate kinase TsaE PF02367.17 EXF75791.1 - 0.033 14.2 0.0 0.054 13.5 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NTPase_1 PF03266.15 EXF75791.1 - 0.046 13.6 0.0 0.1 12.5 0.0 1.5 1 0 0 1 1 1 0 NTPase AAA_23 PF13476.6 EXF75791.1 - 0.047 14.2 0.0 0.075 13.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 EXF75791.1 - 0.053 12.6 0.0 0.091 11.8 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein RuvB_N PF05496.12 EXF75791.1 - 0.055 13.2 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_7 PF12775.7 EXF75791.1 - 0.059 12.9 0.0 0.17 11.4 0.0 1.7 2 1 0 2 2 2 0 P-loop containing dynein motor region DNA_pol3_delta2 PF13177.6 EXF75791.1 - 0.068 13.0 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 DNA polymerase III, delta subunit Zeta_toxin PF06414.12 EXF75791.1 - 0.097 11.9 0.0 0.14 11.4 0.0 1.5 1 1 0 1 1 1 0 Zeta toxin AAA_19 PF13245.6 EXF75791.1 - 0.1 12.9 0.0 0.33 11.3 0.0 1.7 2 0 0 2 2 2 0 AAA domain PhoH PF02562.16 EXF75791.1 - 0.13 11.7 0.0 0.23 10.9 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein ATPase PF06745.13 EXF75791.1 - 0.2 11.0 0.1 0.91 8.8 0.0 1.9 2 0 0 2 2 2 0 KaiC 2-oxoacid_dh PF00198.23 EXF75792.1 - 1.9e-73 246.7 0.1 9.6e-73 244.5 0.0 1.8 2 0 0 2 2 2 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 EXF75792.1 - 1.7e-18 66.2 0.1 2.8e-18 65.5 0.1 1.4 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 EXF75792.1 - 1e-13 51.3 0.1 2.4e-13 50.2 0.1 1.7 1 0 0 1 1 1 1 e3 binding domain Biotin_lipoyl_2 PF13533.6 EXF75792.1 - 0.071 12.9 0.1 0.25 11.2 0.1 1.9 2 0 0 2 2 2 0 Biotin-lipoyl like BEX PF04538.12 EXF75792.1 - 0.11 13.1 2.2 1.7 9.2 0.0 2.4 2 0 0 2 2 2 0 Brain expressed X-linked like family ATP-synt_10 PF05176.14 EXF75793.1 - 9.5e-75 251.2 0.0 1.2e-74 250.8 0.0 1.1 1 0 0 1 1 1 1 ATP10 protein V-SNARE_C PF12352.8 EXF75794.1 - 2.2e-12 47.1 0.8 2.2e-12 47.1 0.8 2.4 3 0 0 3 3 3 1 Snare region anchored in the vesicle membrane C-terminus STAT_alpha PF01017.20 EXF75794.1 - 0.099 12.5 3.2 2.7 7.8 1.2 2.4 2 1 0 2 2 2 0 STAT protein, all-alpha domain Spc7 PF08317.11 EXF75794.1 - 0.23 10.3 9.6 0.39 9.6 9.8 1.3 1 1 0 1 1 1 0 Spc7 kinetochore protein Syntaxin-6_N PF09177.11 EXF75794.1 - 1 10.0 7.0 2.1 9.0 4.6 2.2 1 1 1 2 2 2 0 Syntaxin 6, N-terminal DUF1451 PF07295.11 EXF75794.1 - 4.5 7.3 7.7 7.4 6.6 3.0 2.1 1 1 1 2 2 2 0 Zinc-ribbon containing domain Ribosomal_L29 PF00831.23 EXF75795.1 - 5.9e-17 61.4 3.8 1.2e-16 60.4 0.4 2.1 2 0 0 2 2 2 2 Ribosomal L29 protein zf-H2C2_2 PF13465.6 EXF75796.1 - 6e-19 67.6 44.3 6.4e-08 32.7 0.2 6.9 7 0 0 7 7 7 4 Zinc-finger double domain zf-C2H2 PF00096.26 EXF75796.1 - 1.3e-11 44.3 51.2 0.00037 20.8 0.4 8.3 8 0 0 8 8 8 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EXF75796.1 - 6.7e-11 42.1 42.4 0.0055 17.4 0.4 8.2 8 0 0 8 8 8 5 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EXF75796.1 - 0.0068 16.4 25.7 0.5 10.4 1.9 6.0 5 0 0 5 5 5 3 C2H2-type zinc finger zf-C2H2_aberr PF17017.5 EXF75796.1 - 0.09 12.9 3.3 6.5 6.9 0.1 2.7 1 1 0 2 2 2 0 Aberrant zinc-finger zf-H2C2_5 PF13909.6 EXF75796.1 - 0.2 11.4 28.4 0.18 11.6 0.9 5.9 5 0 0 5 5 5 0 C2H2-type zinc-finger domain BolA PF01722.18 EXF75796.1 - 0.48 10.7 2.8 2.2 8.6 0.1 3.0 2 1 1 3 3 3 0 BolA-like protein zf-C2H2_jaz PF12171.8 EXF75796.1 - 1.8 9.0 25.4 0.35 11.2 0.2 5.4 6 0 0 6 6 6 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EXF75796.1 - 3.7 8.1 20.1 0.56 10.7 0.2 6.1 6 0 0 6 6 6 0 Zinc-finger of C2H2 type AICARFT_IMPCHas PF01808.18 EXF75797.1 - 5.8e-91 305.0 0.0 7.6e-91 304.6 0.0 1.1 1 0 0 1 1 1 1 AICARFT/IMPCHase bienzyme MGS PF02142.22 EXF75797.1 - 1.8e-23 82.6 0.0 3.2e-23 81.7 0.0 1.5 1 0 0 1 1 1 1 MGS-like domain Lactamase_B_2 PF12706.7 EXF75797.1 - 0.046 13.2 0.0 12 5.4 0.0 2.6 2 1 0 2 2 2 0 Beta-lactamase superfamily domain DEAD PF00270.29 EXF75799.1 - 6.9e-51 172.5 0.0 8.6e-49 165.7 0.0 2.3 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.31 EXF75799.1 - 8.6e-26 90.5 0.0 2.4e-25 89.1 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HCNGP PF07818.13 EXF75800.1 - 3.6e-26 91.7 0.0 5.9e-26 90.9 0.0 1.3 1 0 0 1 1 1 1 HCNGP-like protein DUF3712 PF12505.8 EXF75801.1 - 1.4e-25 90.0 3.0 3.5e-25 88.7 2.2 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF3712) SBF_like PF13593.6 EXF75801.1 - 0.086 12.1 0.1 0.12 11.6 0.1 1.1 1 0 0 1 1 1 0 SBF-like CPA transporter family (DUF4137) DUF2997 PF11211.8 EXF75801.1 - 0.22 11.3 0.6 0.47 10.3 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2997) FMN_dh PF01070.18 EXF75802.1 - 3.2e-109 365.2 0.0 3.9e-109 364.9 0.0 1.1 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.28 EXF75802.1 - 3.7e-19 68.7 0.0 1e-18 67.2 0.0 1.8 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Glu_synthase PF01645.17 EXF75802.1 - 1.4e-07 31.1 0.1 2.2e-07 30.4 0.1 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.25 EXF75802.1 - 2.1e-05 23.7 0.2 9.7e-05 21.5 0.1 2.0 1 1 1 2 2 2 1 IMP dehydrogenase / GMP reductase domain His_biosynth PF00977.21 EXF75802.1 - 0.014 14.9 0.0 0.024 14.1 0.0 1.3 1 0 0 1 1 1 0 Histidine biosynthesis protein NMO PF03060.15 EXF75802.1 - 0.02 14.3 0.2 0.03 13.7 0.2 1.2 1 0 0 1 1 1 0 Nitronate monooxygenase Ribul_P_3_epim PF00834.19 EXF75802.1 - 0.055 12.8 0.0 0.092 12.1 0.0 1.3 1 0 0 1 1 1 0 Ribulose-phosphate 3 epimerase family DHO_dh PF01180.21 EXF75802.1 - 0.087 12.0 0.0 0.14 11.3 0.0 1.4 1 1 0 1 1 1 0 Dihydroorotate dehydrogenase HSCB_C PF07743.13 EXF75803.1 - 2.2e-19 69.7 6.8 1.7e-18 66.9 4.8 2.1 2 0 0 2 2 2 1 HSCB C-terminal oligomerisation domain DnaJ PF00226.31 EXF75803.1 - 2.3e-07 30.8 0.3 5.2e-07 29.7 0.3 1.5 1 0 0 1 1 1 1 DnaJ domain PCI PF01399.27 EXF75804.1 - 1.8e-10 41.3 0.0 4.7e-10 39.9 0.0 1.7 1 0 0 1 1 1 1 PCI domain RPN7 PF10602.9 EXF75804.1 - 0.011 15.4 0.1 0.021 14.5 0.1 1.5 1 0 0 1 1 1 0 26S proteasome subunit RPN7 Lipase_GDSL_2 PF13472.6 EXF75805.1 - 3.4e-22 79.7 0.1 4.5e-22 79.3 0.1 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EXF75805.1 - 1.1e-10 41.9 0.0 1.9e-10 41.1 0.0 1.4 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Profilin PF00235.19 EXF75807.1 - 9.9e-44 148.7 1.0 1.1e-43 148.5 1.0 1.0 1 0 0 1 1 1 1 Profilin Got1 PF04178.12 EXF75808.1 - 3.5e-15 56.4 11.7 4.4e-15 56.1 11.7 1.1 1 0 0 1 1 1 1 Got1/Sft2-like family DUF373 PF04123.13 EXF75808.1 - 1.4 8.2 3.4 0.85 9.0 1.7 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF373) YL1_C PF08265.11 EXF75809.1 - 1.4e-15 56.7 0.2 2.2e-15 56.1 0.2 1.3 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain DASH_Dad4 PF08650.10 EXF75810.1 - 4.3e-33 113.1 7.4 4.8e-33 113.0 7.4 1.0 1 0 0 1 1 1 1 DASH complex subunit Dad4 Biotin_carb_C PF02785.19 EXF75810.1 - 0.055 13.6 0.1 0.06 13.5 0.1 1.1 1 0 0 1 1 1 0 Biotin carboxylase C-terminal domain GM_CSF PF01109.17 EXF75810.1 - 0.072 13.3 0.5 0.082 13.1 0.5 1.1 1 0 0 1 1 1 0 Granulocyte-macrophage colony-stimulating factor Actin PF00022.19 EXF75811.1 - 3.2e-57 194.0 0.0 1.1e-33 116.5 0.0 2.3 2 0 0 2 2 2 2 Actin bZIP_1 PF00170.21 EXF75812.1 - 3.3e-09 36.7 6.9 8e-09 35.5 6.9 1.6 1 0 0 1 1 1 1 bZIP transcription factor Fib_alpha PF08702.10 EXF75812.1 - 0.16 12.1 1.1 0.29 11.3 1.1 1.3 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family bZIP_2 PF07716.15 EXF75812.1 - 0.59 10.3 9.0 18 5.5 9.0 2.6 1 1 0 1 1 1 0 Basic region leucine zipper Amidohydro_1 PF01979.20 EXF75813.1 - 5.6e-36 124.6 0.0 7.1e-36 124.2 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EXF75813.1 - 2.6e-09 37.1 3.2 8e-08 32.2 0.2 2.3 2 0 0 2 2 2 2 Amidohydrolase family DUF3606 PF12244.8 EXF75813.1 - 0.022 14.7 0.4 0.055 13.4 0.2 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3606) Pterin_4a PF01329.19 EXF75814.1 - 2.6e-24 85.2 0.1 3.8e-24 84.7 0.1 1.2 1 0 0 1 1 1 1 Pterin 4 alpha carbinolamine dehydratase Endotoxin_mid PF09131.10 EXF75814.1 - 0.058 13.1 0.0 0.069 12.8 0.0 1.2 1 0 0 1 1 1 0 Bacillus thuringiensis delta-Endotoxin, middle domain FA_hydroxylase PF04116.13 EXF75815.1 - 9e-26 90.8 15.8 9e-26 90.8 15.8 2.1 2 1 1 3 3 3 1 Fatty acid hydroxylase superfamily NCA2 PF08637.10 EXF75816.1 - 1.2e-111 372.6 0.1 1.7e-111 372.0 0.1 1.3 1 0 0 1 1 1 1 ATP synthase regulation protein NCA2 TMEM171 PF15471.6 EXF75816.1 - 0.19 10.7 0.1 0.31 10.0 0.1 1.2 1 0 0 1 1 1 0 Transmembrane protein family 171 FCD PF07729.12 EXF75816.1 - 0.34 11.4 2.3 0.64 10.5 0.7 2.3 2 0 0 2 2 2 0 FCD domain Ras PF00071.22 EXF75817.1 - 2.6e-64 215.7 0.0 3e-64 215.5 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EXF75817.1 - 7.5e-34 116.5 0.0 1.3e-33 115.8 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EXF75817.1 - 4.2e-13 49.1 0.0 4.7e-13 49.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EXF75817.1 - 1e-05 25.2 0.0 2.2e-05 24.1 0.0 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EXF75817.1 - 0.00028 20.3 0.0 0.0003 20.2 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EXF75817.1 - 0.0022 18.1 0.0 0.0066 16.5 0.0 1.7 1 1 1 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EXF75817.1 - 0.005 16.8 0.2 2.6 7.9 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase SRPRB PF09439.10 EXF75817.1 - 0.027 13.9 0.0 0.033 13.6 0.0 1.1 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit FeoB_N PF02421.18 EXF75817.1 - 0.05 13.1 0.0 0.25 10.9 0.0 2.0 1 1 0 1 1 1 0 Ferrous iron transport protein B AAA_22 PF13401.6 EXF75817.1 - 0.13 12.6 0.1 0.47 10.7 0.1 2.0 1 1 0 1 1 1 0 AAA domain Nop10p PF04135.12 EXF75818.1 - 0.11 12.5 0.1 0.28 11.3 0.1 1.6 1 0 0 1 1 1 0 Nucleolar RNA-binding protein, Nop10p family AAA PF00004.29 EXF75819.1 - 2.9e-53 179.8 0.0 3.8e-39 134.1 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EXF75819.1 - 1.3e-09 37.7 0.3 1.3e-06 28.1 0.0 2.9 2 0 0 2 2 2 2 AAA+ lid domain AAA_16 PF13191.6 EXF75819.1 - 2.1e-06 28.2 1.5 0.023 15.1 0.5 4.0 1 1 1 3 3 3 2 AAA ATPase domain AAA_5 PF07728.14 EXF75819.1 - 1e-05 25.6 0.1 0.11 12.5 0.0 3.6 3 2 0 3 3 2 2 AAA domain (dynein-related subfamily) Vps4_C PF09336.10 EXF75819.1 - 1.2e-05 25.2 0.0 0.064 13.3 0.0 3.0 3 0 0 3 3 3 2 Vps4 C terminal oligomerisation domain AAA_14 PF13173.6 EXF75819.1 - 0.00011 22.2 0.0 0.08 13.0 0.0 2.6 2 0 0 2 2 2 2 AAA domain CDC48_N PF02359.18 EXF75819.1 - 0.00032 20.8 0.0 0.02 15.0 0.0 2.6 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), N-terminal domain AAA_22 PF13401.6 EXF75819.1 - 0.00038 20.8 1.0 0.6 10.4 0.3 3.7 2 2 1 3 3 3 1 AAA domain AAA_25 PF13481.6 EXF75819.1 - 0.00065 19.3 0.9 0.14 11.8 0.0 3.1 2 2 1 3 3 3 1 AAA domain AAA_33 PF13671.6 EXF75819.1 - 0.0012 19.1 0.0 0.15 12.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.6 EXF75819.1 - 0.0015 18.8 0.0 0.075 13.3 0.0 2.7 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 EXF75819.1 - 0.0061 16.9 0.0 5.1 7.5 0.0 2.8 2 0 0 2 2 2 1 RNA helicase RuvB_N PF05496.12 EXF75819.1 - 0.018 14.8 0.0 0.1 12.4 0.0 2.3 2 1 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain Rad17 PF03215.15 EXF75819.1 - 0.07 13.0 0.0 0.21 11.5 0.0 1.8 2 0 0 2 2 2 0 Rad17 P-loop domain DUF815 PF05673.13 EXF75819.1 - 0.083 12.0 0.1 0.33 10.1 0.0 2.0 3 0 0 3 3 3 0 Protein of unknown function (DUF815) Torsin PF06309.11 EXF75819.1 - 0.096 12.8 0.0 0.2 11.7 0.0 1.5 1 0 0 1 1 1 0 Torsin AAA_7 PF12775.7 EXF75819.1 - 0.18 11.3 0.4 7.7 6.0 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region SE PF08491.10 EXF75820.1 - 5.5e-86 288.0 0.0 7.1e-86 287.7 0.0 1.1 1 0 0 1 1 1 1 Squalene epoxidase DAO PF01266.24 EXF75820.1 - 3.8e-10 39.9 0.3 6.6e-07 29.2 0.4 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 EXF75820.1 - 3.5e-09 36.4 1.0 1.4e-06 27.8 0.1 2.4 2 1 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 EXF75820.1 - 2.6e-05 24.3 0.5 5.9e-05 23.2 0.5 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 EXF75820.1 - 0.00011 21.4 1.0 0.00027 20.1 1.0 1.6 1 1 0 1 1 1 1 Glucose inhibited division protein A Thi4 PF01946.17 EXF75820.1 - 0.00012 21.4 0.0 0.00021 20.6 0.0 1.3 1 0 0 1 1 1 1 Thi4 family Pyr_redox PF00070.27 EXF75820.1 - 0.0028 18.2 2.1 0.12 12.9 0.2 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EXF75820.1 - 0.003 16.8 0.2 0.013 14.8 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EXF75820.1 - 0.0034 16.5 0.3 0.005 16.0 0.3 1.2 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 EXF75820.1 - 0.0035 16.8 1.3 0.005 16.2 0.2 1.7 2 0 0 2 2 2 1 FAD dependent oxidoreductase ApbA PF02558.16 EXF75820.1 - 0.0074 15.9 0.1 0.013 15.2 0.1 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA NAD_Gly3P_dh_N PF01210.23 EXF75820.1 - 0.0097 15.9 0.0 0.016 15.2 0.0 1.3 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 3HCDH_N PF02737.18 EXF75820.1 - 0.053 13.4 0.1 0.094 12.6 0.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain HI0933_like PF03486.14 EXF75820.1 - 0.06 12.0 0.1 0.093 11.4 0.1 1.2 1 0 0 1 1 1 0 HI0933-like protein Lycopene_cycl PF05834.12 EXF75820.1 - 0.061 12.4 0.1 0.11 11.5 0.1 1.4 1 0 0 1 1 1 0 Lycopene cyclase protein Shikimate_DH PF01488.20 EXF75820.1 - 0.14 12.3 0.0 0.23 11.5 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Glycos_transf_2 PF00535.26 EXF75821.1 - 3.4e-26 92.1 0.0 5.8e-26 91.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 EXF75821.1 - 4.3e-08 33.3 0.1 1.3e-06 28.4 0.0 2.5 2 1 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 EXF75821.1 - 0.00011 21.8 0.0 0.00018 21.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.6 EXF75821.1 - 0.018 15.6 0.0 0.037 14.5 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferase family 2 DAAD PF18752.1 EXF75822.1 - 0.2 11.5 2.3 0.36 10.6 2.3 1.5 1 0 0 1 1 1 0 Dictyosteliid AID/APOBEC-like Deaminase DUF3487 PF11990.8 EXF75823.1 - 0.049 13.5 0.0 0.15 12.0 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3487) SMK-1 PF04802.15 EXF75824.1 - 2.3e-84 282.0 0.1 4.8e-84 281.0 0.1 1.5 1 0 0 1 1 1 1 Component of IIS longevity pathway SMK-1 DUF5630 PF18632.1 EXF75824.1 - 0.12 11.7 0.0 0.2 11.0 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5630) Aldo_ket_red PF00248.21 EXF75826.1 - 9.4e-66 222.0 0.0 1.2e-65 221.6 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family WD40 PF00400.32 EXF75829.1 - 5.7e-11 42.8 0.0 0.058 14.3 0.0 4.5 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EXF75829.1 - 0.00026 21.2 0.0 3.1 8.2 0.0 4.1 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain EIF_2_alpha PF07541.12 EXF75830.1 - 2.6e-37 127.5 0.0 5.3e-37 126.5 0.0 1.5 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.23 EXF75830.1 - 4.1e-14 52.7 0.9 8.9e-14 51.6 0.9 1.6 1 0 0 1 1 1 1 S1 RNA binding domain HATPase_c PF02518.26 EXF75831.1 - 2.7e-26 92.3 0.2 5.1e-26 91.4 0.2 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EXF75831.1 - 3.5e-23 81.9 0.2 2.8e-22 79.0 0.0 2.4 2 0 0 2 2 2 1 Response regulator receiver domain PAS_3 PF08447.12 EXF75831.1 - 1.4e-22 79.7 1.3 9e-12 45.1 0.4 3.9 3 0 0 3 3 3 3 PAS fold HisKA PF00512.25 EXF75831.1 - 1e-19 70.3 0.5 3.8e-19 68.5 0.1 2.3 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain PAS_9 PF13426.7 EXF75831.1 - 1.8e-09 37.8 0.0 0.0049 17.1 0.0 3.8 3 0 0 3 3 3 2 PAS domain PAS PF00989.25 EXF75831.1 - 7.7e-09 35.5 0.0 0.0062 16.5 0.0 2.8 2 0 0 2 2 2 2 PAS fold PAS_4 PF08448.10 EXF75831.1 - 1.8e-08 34.6 0.5 8.1e-05 22.8 0.1 3.3 4 0 0 4 4 4 2 PAS fold PAS_8 PF13188.7 EXF75831.1 - 0.02 14.9 0.0 0.79 9.8 0.0 2.5 2 0 0 2 2 2 0 PAS domain Cpn60_TCP1 PF00118.24 EXF75833.1 - 7.6e-172 572.3 0.1 8.6e-172 572.1 0.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family DUF1168 PF06658.12 EXF75834.1 - 3.7e-36 123.9 20.2 9.4e-36 122.6 20.2 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF1168) Lyase_catalyt PF09093.11 EXF75834.1 - 0.041 13.0 0.0 0.058 12.5 0.0 1.1 1 0 0 1 1 1 0 Lyase, catalytic XRN_M PF17846.1 EXF75834.1 - 1.8 7.4 6.9 2.4 7.0 6.9 1.1 1 0 0 1 1 1 0 Xrn1 helical domain Peptidase_S49_N PF08496.10 EXF75834.1 - 3.8 7.5 6.8 0.35 10.9 1.9 1.8 2 0 0 2 2 2 0 Peptidase family S49 N-terminal DNA_pol3_a_NII PF11490.8 EXF75834.1 - 8.2 6.3 9.0 16 5.4 9.0 1.4 1 0 0 1 1 1 0 DNA polymerase III polC-type N-terminus II His_Phos_1 PF00300.22 EXF75835.1 - 3.4e-26 92.1 0.0 7.2e-26 91.1 0.0 1.6 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Mito_carr PF00153.27 EXF75836.1 - 1.4e-58 194.8 0.2 4.1e-21 74.7 0.0 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein SPRY PF00622.28 EXF75837.1 - 0.025 14.7 0.1 0.27 11.4 0.0 2.6 3 0 0 3 3 3 0 SPRY domain PHINT_rpt PF14882.6 EXF75838.1 - 0.052 13.8 2.6 0.16 12.3 2.6 1.8 1 0 0 1 1 1 0 Phage-integrase repeat unit SMC_Nse1 PF07574.13 EXF75839.1 - 2.3e-73 246.2 0.1 3.4e-73 245.7 0.1 1.2 1 0 0 1 1 1 1 Nse1 non-SMC component of SMC5-6 complex zf-RING-like PF08746.11 EXF75839.1 - 3.4e-15 56.1 12.6 5.4e-15 55.4 12.6 1.3 1 0 0 1 1 1 1 RING-like domain zf-HC5HC2H PF13771.6 EXF75839.1 - 0.063 13.5 4.5 0.16 12.2 4.5 1.7 1 0 0 1 1 1 0 PHD-like zinc-binding domain zf-RING_2 PF13639.6 EXF75839.1 - 0.083 13.2 8.8 0.14 12.5 8.8 1.4 1 0 0 1 1 1 0 Ring finger domain zinc-ribbons_6 PF07191.12 EXF75839.1 - 2.3 8.2 8.7 4.7 7.3 1.3 2.3 1 1 1 2 2 2 0 zinc-ribbons Ycf1 PF05758.12 EXF75840.1 - 0.041 11.7 0.0 0.061 11.2 0.0 1.1 1 0 0 1 1 1 0 Ycf1 NB-ARC PF00931.22 EXF75842.1 - 5.3e-09 35.6 0.0 8.7e-09 34.9 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain TPR_12 PF13424.6 EXF75842.1 - 3.5e-08 33.6 11.7 0.0046 17.2 0.4 4.9 4 1 1 5 5 5 4 Tetratricopeptide repeat TPR_2 PF07719.17 EXF75842.1 - 4.3e-07 29.6 9.0 0.39 11.0 0.1 5.9 6 0 0 6 6 6 3 Tetratricopeptide repeat AAA_16 PF13191.6 EXF75842.1 - 4.1e-05 24.0 0.1 0.00025 21.5 0.1 2.4 1 1 0 1 1 1 1 AAA ATPase domain TPR_1 PF00515.28 EXF75842.1 - 0.00033 20.3 5.3 1.1 9.3 0.0 4.8 5 0 0 5 5 5 2 Tetratricopeptide repeat SPO22 PF08631.10 EXF75842.1 - 0.00067 19.2 0.3 0.0019 17.7 0.3 1.8 1 0 0 1 1 1 1 Meiosis protein SPO22/ZIP4 like TPR_10 PF13374.6 EXF75842.1 - 0.0052 16.6 2.6 4.1 7.4 0.0 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.6 EXF75842.1 - 0.0056 16.8 2.8 32 5.1 0.1 4.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_7 PF13176.6 EXF75842.1 - 0.0056 16.6 1.1 47 4.3 0.0 4.7 4 0 0 4 4 4 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EXF75842.1 - 0.0069 16.6 1.7 4.5 7.6 0.2 3.8 4 0 0 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 ATPase_2 PF01637.18 EXF75842.1 - 0.015 15.2 0.0 0.033 14.1 0.0 1.5 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea Helo_like_N PF17111.5 EXF75842.1 - 0.017 14.5 0.0 1.2 8.5 0.0 2.5 2 0 0 2 2 2 0 Fungal N-terminal domain of STAND proteins HEPN_RnaseLS PF18869.1 EXF75842.1 - 0.039 14.1 0.5 0.15 12.2 0.4 2.0 2 0 0 2 2 2 0 RnaseLS-like HEPN EzrA PF06160.12 EXF75842.1 - 0.04 12.1 0.0 0.27 9.3 0.0 2.0 2 0 0 2 2 2 0 Septation ring formation regulator, EzrA AAA_22 PF13401.6 EXF75842.1 - 0.063 13.6 0.0 0.16 12.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain HemY_N PF07219.13 EXF75842.1 - 0.87 9.8 3.2 9.3 6.5 0.0 2.8 3 0 0 3 3 2 0 HemY protein N-terminus TPR_16 PF13432.6 EXF75842.1 - 9.4 7.0 7.4 62 4.4 0.4 4.2 3 2 0 3 3 3 0 Tetratricopeptide repeat Clr2 PF10383.9 EXF75843.1 - 2e-10 41.7 6.4 4.5e-10 40.5 0.0 3.0 2 1 0 2 2 2 1 Transcription-silencing protein Clr2 Clr2_transil PF16761.5 EXF75843.1 - 3.7e-08 34.1 1.4 9.7e-08 32.7 1.4 1.7 1 1 0 1 1 1 1 Transcription-silencing protein, cryptic loci regulator Clr2 Ndc1_Nup PF09531.10 EXF75843.1 - 8.2 5.0 13.1 12 4.4 13.1 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Glyco_hydro_43 PF04616.14 EXF75844.1 - 2.4e-32 112.4 5.5 6.4e-31 107.7 5.5 2.1 1 1 0 1 1 1 1 Glycosyl hydrolases family 43 DUF2052 PF09747.9 EXF75845.1 - 4.7e-32 111.7 15.0 3.2e-16 60.1 9.3 2.1 1 1 1 2 2 2 2 Coiled-coil domain containing protein (DUF2052) Response_reg PF00072.24 EXF75846.1 - 2.4e-20 72.8 0.0 4.1e-14 52.7 0.0 2.4 2 0 0 2 2 2 2 Response regulator receiver domain Bot1p PF12298.8 EXF75847.1 - 7.4e-49 166.2 6.3 1.1e-48 165.7 6.3 1.3 1 0 0 1 1 1 1 Eukaryotic mitochondrial regulator protein Y_phosphatase3 PF13350.6 EXF75848.1 - 2.2e-61 207.8 0.0 2.5e-61 207.6 0.0 1.0 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 EXF75848.1 - 0.00044 19.9 0.0 0.00061 19.4 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase2 PF03162.13 EXF75848.1 - 0.0043 16.7 0.0 0.0072 15.9 0.0 1.5 1 0 0 1 1 1 1 Tyrosine phosphatase family APH PF01636.23 EXF75848.1 - 0.073 13.0 0.4 3.3 7.6 0.0 2.5 2 1 1 3 3 3 0 Phosphotransferase enzyme family DSPc PF00782.20 EXF75848.1 - 0.13 12.1 0.0 0.54 10.1 0.0 1.9 2 0 0 2 2 2 0 Dual specificity phosphatase, catalytic domain Myotub-related PF06602.14 EXF75848.1 - 0.15 11.0 0.0 0.23 10.3 0.0 1.2 1 0 0 1 1 1 0 Myotubularin-like phosphatase domain MARVEL PF01284.23 EXF75850.1 - 0.0012 18.9 12.6 0.0012 18.9 12.6 2.1 1 1 1 2 2 2 2 Membrane-associating domain VIT1 PF01988.19 EXF75850.1 - 1.4 8.8 5.9 0.93 9.3 4.6 1.4 1 1 0 1 1 1 0 VIT family BAR PF03114.18 EXF75852.1 - 8.3e-14 51.8 0.1 1.2e-13 51.2 0.1 1.2 1 0 0 1 1 1 1 BAR domain SH3_1 PF00018.28 EXF75852.1 - 2.4e-10 39.8 0.3 6.1e-10 38.6 0.3 1.7 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EXF75852.1 - 1.4e-09 37.6 0.1 3.5e-09 36.4 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EXF75852.1 - 8.8e-09 34.9 0.1 2e-08 33.8 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain DUF2439 PF10382.9 EXF75853.1 - 2.2e-26 92.0 0.1 4.6e-26 91.0 0.1 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF2439) Zn_clus PF00172.18 EXF75854.1 - 0.27 11.4 9.6 0.59 10.3 9.6 1.6 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain dCMP_cyt_deam_1 PF00383.23 EXF75855.1 - 6e-22 77.4 0.0 1.7e-21 76.0 0.0 1.7 1 1 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EXF75855.1 - 1.1e-18 67.3 0.0 2.7e-08 33.6 0.0 2.3 2 0 0 2 2 2 2 MafB19-like deaminase Bd3614-deam PF14439.6 EXF75855.1 - 0.0001 22.4 0.4 0.0068 16.5 0.0 2.5 2 0 0 2 2 2 1 Bd3614-like deaminase DUF3275 PF11679.8 EXF75855.1 - 1.3 8.9 0.0 1.3 8.9 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3275) Xan_ur_permease PF00860.20 EXF75856.1 - 1e-26 93.6 34.2 1.5e-26 93.0 29.9 2.5 2 1 0 2 2 2 1 Permease family MFS_MOT1 PF16983.5 EXF75856.1 - 3.8 7.9 23.0 0.069 13.5 4.8 3.4 2 1 0 3 3 3 0 Molybdate transporter of MFS superfamily Na_H_Exchanger PF00999.21 EXF75859.1 - 2.5e-59 201.0 48.0 3.6e-59 200.5 48.0 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family A_deaminase PF00962.22 EXF75861.1 - 1.9e-72 244.4 0.0 2.1e-72 244.2 0.0 1.0 1 0 0 1 1 1 1 Adenosine/AMP deaminase TRM PF02005.16 EXF75861.1 - 0.049 12.8 0.0 0.068 12.3 0.0 1.1 1 0 0 1 1 1 0 N2,N2-dimethylguanosine tRNA methyltransferase Abhydrolase_3 PF07859.13 EXF75862.1 - 8.1e-34 117.3 0.0 5.1e-24 85.3 0.0 2.4 2 0 0 2 2 2 2 alpha/beta hydrolase fold Lipase_3 PF01764.25 EXF75862.1 - 0.05 13.5 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 Lipase (class 3) Say1_Mug180 PF10340.9 EXF75862.1 - 0.19 10.5 0.0 0.3 9.9 0.0 1.2 1 0 0 1 1 1 0 Steryl acetyl hydrolase HET PF06985.11 EXF75864.1 - 1.6e-34 119.4 0.7 2.7e-34 118.6 0.7 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Glyco_hydro_cc PF11790.8 EXF75866.1 - 4.4e-45 154.1 2.4 5.5e-45 153.8 2.4 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core Aminotran_3 PF00202.21 EXF75867.1 - 3.9e-114 381.5 0.0 5.1e-114 381.1 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 EXF75867.1 - 4.6e-05 22.7 0.0 0.00013 21.3 0.0 1.7 1 1 0 1 1 1 1 Aminotransferase class I and II SnoaL_2 PF12680.7 EXF75868.1 - 0.025 15.2 0.0 0.094 13.4 0.0 1.8 2 0 0 2 2 2 0 SnoaL-like domain Cutinase PF01083.22 EXF75869.1 - 4.8e-46 156.9 2.8 5.7e-46 156.7 2.8 1.1 1 0 0 1 1 1 1 Cutinase DUF2974 PF11187.8 EXF75869.1 - 0.019 14.5 0.1 0.033 13.7 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) TPIP1 PF15338.6 EXF75869.1 - 0.075 13.1 0.8 0.15 12.2 0.2 1.8 1 1 1 2 2 2 0 p53-regulated apoptosis-inducing protein 1 Palm_thioest PF02089.15 EXF75869.1 - 0.089 12.6 0.2 0.097 12.5 0.2 1.2 1 0 0 1 1 1 0 Palmitoyl protein thioesterase ATG27 PF09451.10 EXF75871.1 - 6.6e-102 340.9 0.0 8.2e-102 340.6 0.0 1.0 1 0 0 1 1 1 1 Autophagy-related protein 27 TruB_C PF09142.11 EXF75872.1 - 0.03 14.1 1.7 0.072 12.9 1.7 1.7 1 0 0 1 1 1 0 tRNA Pseudouridine synthase II, C terminal SARAF PF06682.12 EXF75872.1 - 0.16 11.6 1.0 0.32 10.6 1.0 1.4 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Hexapep PF00132.24 EXF75873.1 - 1e-05 25.1 3.0 0.025 14.3 2.7 3.5 1 1 1 2 2 2 2 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.7 EXF75873.1 - 0.00023 21.6 0.0 0.00049 20.5 0.0 1.6 1 1 0 1 1 1 1 MobA-like NTP transferase domain DUF4954 PF16314.5 EXF75873.1 - 0.00028 19.2 0.3 0.00039 18.7 0.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4954) Fucokinase PF07959.12 EXF75873.1 - 0.00082 18.4 0.1 0.0012 17.8 0.1 1.2 1 0 0 1 1 1 1 L-fucokinase NTP_transferase PF00483.23 EXF75873.1 - 0.003 17.2 0.0 0.0066 16.1 0.0 1.4 2 0 0 2 2 2 1 Nucleotidyl transferase Hexapep_2 PF14602.6 EXF75873.1 - 0.23 11.3 5.6 0.22 11.3 0.2 3.1 3 1 0 3 3 3 0 Hexapeptide repeat of succinyl-transferase zf-C2H2 PF00096.26 EXF75874.1 - 0.00015 22.1 14.5 0.0012 19.2 4.2 3.7 2 1 0 2 2 2 2 Zinc finger, C2H2 type FOXP-CC PF16159.5 EXF75874.1 - 0.024 15.3 0.5 0.024 15.3 0.5 3.5 3 1 1 4 4 4 0 FOXP coiled-coil domain zf-C2H2_4 PF13894.6 EXF75874.1 - 0.036 14.9 3.2 0.036 14.9 3.2 4.0 4 0 0 4 4 4 0 C2H2-type zinc finger YdjO PF14169.6 EXF75874.1 - 0.076 12.8 0.1 5.7 6.7 0.1 2.6 2 0 0 2 2 2 0 Cold-inducible protein YdjO IBR PF01485.21 EXF75874.1 - 0.17 12.1 2.7 2.7 8.3 2.5 2.4 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain LRR_6 PF13516.6 EXF75875.1 - 0.32 11.2 4.3 1.5 9.1 0.0 3.5 4 0 0 4 4 4 0 Leucine Rich repeat Glyco_hydro_12 PF01670.16 EXF75876.1 - 7.3e-48 163.4 11.0 9e-48 163.1 11.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 12 Phage_holin_5_1 PF06946.11 EXF75876.1 - 0.023 15.0 3.8 0.16 12.4 1.9 2.4 2 1 0 2 2 2 0 Bacteriophage A118-like holin, Hol118 PPV_E2_C PF00511.17 EXF75876.1 - 7.7 6.8 8.8 21 5.4 0.3 2.5 1 1 1 2 2 2 0 E2 (early) protein, C terminal Fungal_trans PF04082.18 EXF75877.1 - 6.2e-10 38.5 0.0 1.2e-09 37.6 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain DASH_Hsk3 PF08227.11 EXF75877.1 - 1.1 9.7 3.7 2.7 8.4 3.7 1.7 1 0 0 1 1 1 0 DASH complex subunit Hsk3 like PS-DH PF14765.6 EXF75878.1 - 6.7e-72 242.2 0.0 4.2e-71 239.6 0.0 2.2 2 0 0 2 2 2 1 Polyketide synthase dehydratase ketoacyl-synt PF00109.26 EXF75878.1 - 1.7e-68 230.9 0.0 3.1e-68 230.1 0.0 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.10 EXF75878.1 - 4.3e-57 192.9 0.0 1.7e-56 191.0 0.0 2.1 3 0 0 3 3 3 1 KR domain Acyl_transf_1 PF00698.21 EXF75878.1 - 1e-53 182.9 0.3 2.8e-53 181.5 0.1 1.8 2 0 0 2 2 2 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EXF75878.1 - 5.4e-30 103.8 0.1 1.3e-29 102.6 0.1 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 EXF75878.1 - 1.1e-19 70.9 0.0 2.8e-19 69.6 0.0 1.7 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension adh_short PF00106.25 EXF75878.1 - 6.4e-07 29.0 0.0 1.6e-06 27.7 0.0 1.7 1 0 0 1 1 1 1 short chain dehydrogenase Thiolase_N PF00108.23 EXF75878.1 - 0.0034 16.8 0.2 0.0079 15.6 0.2 1.5 1 0 0 1 1 1 1 Thiolase, N-terminal domain ACP_syn_III PF08545.10 EXF75878.1 - 0.018 14.9 0.6 0.061 13.2 0.6 1.9 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III PP-binding PF00550.25 EXF75878.1 - 0.019 15.3 0.1 0.055 13.8 0.1 1.8 1 0 0 1 1 1 0 Phosphopantetheine attachment site ADH_N PF08240.12 EXF75878.1 - 0.035 14.0 0.0 0.1 12.5 0.0 1.8 1 0 0 1 1 1 0 Alcohol dehydrogenase GroES-like domain MFS_1 PF07690.16 EXF75879.1 - 1.6e-36 126.0 50.2 1.6e-36 126.0 50.2 2.4 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF75879.1 - 2.2e-07 30.1 12.0 2.2e-07 30.1 12.0 3.6 3 1 0 3 3 3 2 Sugar (and other) transporter OATP PF03137.20 EXF75879.1 - 0.0043 15.4 1.5 0.0043 15.4 1.5 3.0 2 1 1 3 3 3 1 Organic Anion Transporter Polypeptide (OATP) family FAD_binding_3 PF01494.19 EXF75880.1 - 9.1e-26 90.9 0.2 1.7e-25 90.1 0.2 1.4 1 1 0 1 1 1 1 FAD binding domain Lycopene_cycl PF05834.12 EXF75880.1 - 4.6e-07 29.2 0.6 0.0031 16.6 0.0 2.3 2 0 0 2 2 2 2 Lycopene cyclase protein Pyr_redox_3 PF13738.6 EXF75880.1 - 5.2e-06 25.9 1.9 0.0038 16.5 0.3 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EXF75880.1 - 1.9e-05 24.4 1.2 0.0022 17.6 1.1 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EXF75880.1 - 9.3e-05 22.6 0.1 0.00022 21.4 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EXF75880.1 - 0.00018 20.8 2.0 0.15 11.2 0.2 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EXF75880.1 - 0.00032 19.9 0.1 0.00043 19.5 0.1 1.1 1 0 0 1 1 1 1 Glucose inhibited division protein A NAD_binding_9 PF13454.6 EXF75880.1 - 0.0044 17.0 0.4 1.2 9.1 0.0 2.5 2 0 0 2 2 2 2 FAD-NAD(P)-binding FAD_binding_2 PF00890.24 EXF75880.1 - 0.14 11.2 0.4 0.27 10.3 0.4 1.4 1 0 0 1 1 1 0 FAD binding domain DUF2834 PF11196.8 EXF75881.1 - 0.0034 17.7 1.0 0.0034 17.7 1.0 3.3 3 1 0 3 3 3 1 Protein of unknown function (DUF2834) DUF1270 PF06900.11 EXF75881.1 - 0.069 13.5 0.1 0.069 13.5 0.1 3.6 4 0 0 4 4 4 0 Protein of unknown function (DUF1270) PhzC-PhzF PF02567.16 EXF75882.1 - 1.1e-36 126.8 0.2 3.3e-36 125.2 0.2 1.7 1 1 0 1 1 1 1 Phenazine biosynthesis-like protein Amidohydro_3 PF07969.11 EXF75883.1 - 3e-19 69.8 0.0 3.5e-19 69.6 0.0 1.0 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_1 PF01979.20 EXF75883.1 - 0.01 15.2 0.0 2.6 7.2 0.0 2.1 2 0 0 2 2 2 0 Amidohydrolase family Pox_Ag35 PF03286.14 EXF75883.1 - 0.043 13.6 0.0 0.06 13.1 0.0 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein MFS_1 PF07690.16 EXF75885.1 - 0.21 10.5 0.0 0.28 10.1 0.0 1.1 1 0 0 1 1 1 0 Major Facilitator Superfamily SnoaL PF07366.12 EXF75886.1 - 2.4e-05 24.1 0.0 4.8e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 SnoaL-like polyketide cyclase SnoaL_2 PF12680.7 EXF75886.1 - 2.6e-05 24.8 0.0 0.00024 21.7 0.0 2.3 2 0 0 2 2 2 1 SnoaL-like domain Fungal_trans_2 PF11951.8 EXF75887.1 - 4.5e-25 88.3 0.0 5.8e-25 87.9 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF75887.1 - 2.6e-08 33.9 11.1 6.9e-08 32.5 11.1 1.8 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Cu_amine_oxid PF01179.20 EXF75888.1 - 2.3e-150 501.1 0.0 2.8e-150 500.8 0.0 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN3 PF02728.16 EXF75888.1 - 5.1e-20 71.8 0.0 1.6e-19 70.1 0.0 1.9 1 0 0 1 1 1 1 Copper amine oxidase, N3 domain Cu_amine_oxidN2 PF02727.16 EXF75888.1 - 2.3e-12 47.0 0.1 4.4e-12 46.1 0.1 1.5 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain DUF4105 PF13387.6 EXF75888.1 - 0.021 14.5 0.0 0.049 13.3 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4105) AA_permease_2 PF13520.6 EXF75889.1 - 2.3e-52 178.3 51.0 2.9e-52 177.9 51.0 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EXF75889.1 - 2.6e-18 65.9 41.5 3.5e-18 65.4 41.5 1.1 1 0 0 1 1 1 1 Amino acid permease Erf4 PF10256.9 EXF75889.1 - 0.15 12.2 0.0 0.64 10.1 0.0 2.0 2 0 0 2 2 2 0 Golgin subfamily A member 7/ERF4 family DUF3493 PF11998.8 EXF75889.1 - 0.32 11.2 4.4 0.38 10.9 0.0 3.2 3 0 0 3 3 3 0 Low psii accumulation1 / Rep27 Aldedh PF00171.22 EXF75890.1 - 1e-182 607.8 0.0 1.2e-182 607.6 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family AMP-binding PF00501.28 EXF75891.1 - 2e-53 181.6 0.0 2.7e-53 181.1 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme Thioesterase PF00975.20 EXF75891.1 - 9.8e-28 97.8 0.0 7.5e-27 94.9 0.0 2.3 2 1 0 2 2 2 1 Thioesterase domain PP-binding PF00550.25 EXF75891.1 - 1.8e-10 41.0 1.1 4.2e-10 39.8 0.1 2.2 2 0 0 2 2 2 1 Phosphopantetheine attachment site Abhydrolase_6 PF12697.7 EXF75891.1 - 0.015 15.9 0.3 0.034 14.8 0.3 1.6 1 0 0 1 1 1 0 Alpha/beta hydrolase family Fer4_NifH PF00142.18 EXF75892.1 - 0.11 12.0 0.0 0.16 11.4 0.0 1.2 1 0 0 1 1 1 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family p450 PF00067.22 EXF75893.1 - 2.5e-64 217.8 0.0 3.1e-64 217.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DAO PF01266.24 EXF75894.1 - 5.3e-30 105.2 0.0 6.2e-30 105.0 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Trp_halogenase PF04820.14 EXF75894.1 - 2e-07 30.2 0.2 7.1e-06 25.1 0.2 2.4 1 1 0 1 1 1 1 Tryptophan halogenase NAD_binding_9 PF13454.6 EXF75894.1 - 5.7e-05 23.1 0.1 0.025 14.6 0.0 2.5 2 0 0 2 2 2 2 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 EXF75894.1 - 0.001 18.3 0.0 0.071 12.3 0.0 2.8 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EXF75894.1 - 0.0045 17.2 0.0 0.012 15.8 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 EXF75894.1 - 0.013 14.6 0.0 0.15 11.1 0.0 2.1 2 0 0 2 2 2 0 Glucose inhibited division protein A GMC_oxred_N PF00732.19 EXF75894.1 - 0.019 14.3 0.0 4.8 6.5 0.0 2.2 2 0 0 2 2 2 0 GMC oxidoreductase Pyr_redox PF00070.27 EXF75894.1 - 0.048 14.2 0.0 1.1 9.9 0.0 2.8 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Sacchrp_dh_NADP PF03435.18 EXF75894.1 - 0.055 13.7 0.0 0.18 12.0 0.0 1.9 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain TrkA_N PF02254.18 EXF75894.1 - 0.089 13.1 0.0 0.19 12.0 0.0 1.6 1 0 0 1 1 1 0 TrkA-N domain NAD_binding_7 PF13241.6 EXF75894.1 - 0.11 12.9 0.0 0.24 11.8 0.0 1.6 1 0 0 1 1 1 0 Putative NAD(P)-binding DUF3638 PF12340.8 EXF75898.1 - 2.8e-95 317.9 0.6 4.9e-95 317.1 0.6 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3638) DUF3645 PF12359.8 EXF75898.1 - 1.1e-15 56.7 0.6 2.2e-15 55.7 0.1 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3645) DUF3825 PF12873.7 EXF75898.1 - 0.089 12.2 0.2 0.19 11.2 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3825) UNC-93 PF05978.16 EXF75899.1 - 1e-14 54.5 2.0 1e-14 54.5 2.0 2.9 2 1 1 3 3 3 1 Ion channel regulatory protein UNC-93 MFS_1 PF07690.16 EXF75899.1 - 1.8e-14 53.4 20.6 1.8e-14 53.4 20.6 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF75899.1 - 0.12 11.2 20.5 0.032 13.1 6.3 3.1 2 1 1 3 3 3 0 Sugar (and other) transporter Ring_hydroxyl_A PF00848.19 EXF75900.1 - 3.9e-23 82.5 7.0 7.9e-20 71.7 7.0 2.3 1 1 0 1 1 1 1 Ring hydroxylating alpha subunit (catalytic domain) Rieske PF00355.26 EXF75900.1 - 1.2e-16 60.4 0.1 3.4e-16 58.9 0.0 1.8 2 0 0 2 2 2 1 Rieske [2Fe-2S] domain CorC_HlyC PF03471.17 EXF75900.1 - 0.14 12.2 0.0 0.41 10.7 0.0 1.8 2 0 0 2 2 2 0 Transporter associated domain DAO PF01266.24 EXF75901.1 - 3.8e-30 105.7 0.0 5e-30 105.3 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EXF75901.1 - 0.00023 21.2 0.0 0.015 15.3 0.0 2.4 2 0 0 2 2 2 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 EXF75901.1 - 0.00041 20.5 0.2 0.0015 18.7 0.0 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EXF75901.1 - 0.0017 17.6 0.0 0.031 13.5 0.0 2.0 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EXF75901.1 - 0.028 13.3 0.0 3.7 6.3 0.0 2.2 2 0 0 2 2 2 0 Tryptophan halogenase GIDA PF01134.22 EXF75901.1 - 0.044 12.9 0.0 0.14 11.2 0.0 1.8 2 0 0 2 2 2 0 Glucose inhibited division protein A NAD_binding_7 PF13241.6 EXF75901.1 - 0.069 13.6 0.0 0.12 12.8 0.0 1.5 1 1 0 1 1 1 0 Putative NAD(P)-binding Pyr_redox_3 PF13738.6 EXF75901.1 - 0.081 12.2 0.0 3.5 6.8 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EXF75901.1 - 0.22 10.7 0.0 0.42 9.8 0.0 1.3 1 0 0 1 1 1 0 Thi4 family Fungal_trans PF04082.18 EXF75902.1 - 1.9e-07 30.4 1.0 3.4e-07 29.6 1.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain GP3_package PF16677.5 EXF75902.1 - 0.025 14.7 0.0 0.48 10.6 0.0 2.5 2 0 0 2 2 2 0 DNA-packaging protein gp3 GCV_T PF01571.21 EXF75903.1 - 6.1e-66 222.4 0.0 1.4e-65 221.2 0.0 1.6 2 0 0 2 2 2 1 Aminomethyltransferase folate-binding domain DAO PF01266.24 EXF75903.1 - 1.5e-47 162.9 1.6 2.3e-47 162.3 1.6 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAO_M PF16350.5 EXF75903.1 - 3.6e-19 68.8 0.0 7.1e-19 67.9 0.0 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase central domain GCV_T_C PF08669.11 EXF75903.1 - 1.3e-17 63.5 0.0 3.6e-17 62.0 0.0 1.9 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain Pyr_redox_2 PF07992.14 EXF75903.1 - 1.4e-06 27.7 0.2 0.034 13.4 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EXF75903.1 - 4.6e-05 23.9 0.9 0.083 13.5 0.2 2.9 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EXF75903.1 - 0.00031 19.9 0.3 0.00059 19.0 0.3 1.4 1 0 0 1 1 1 1 FAD binding domain Trp_halogenase PF04820.14 EXF75903.1 - 0.00084 18.3 0.8 0.013 14.4 0.0 2.1 2 0 0 2 2 2 1 Tryptophan halogenase NAD_binding_9 PF13454.6 EXF75903.1 - 0.0026 17.8 1.0 0.66 10.0 0.1 2.4 2 0 0 2 2 2 2 FAD-NAD(P)-binding TrkA_N PF02254.18 EXF75903.1 - 0.0041 17.4 0.3 0.016 15.5 0.1 2.1 2 0 0 2 2 1 1 TrkA-N domain Shikimate_DH PF01488.20 EXF75903.1 - 0.0068 16.5 0.1 0.015 15.4 0.1 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase ThiF PF00899.21 EXF75903.1 - 0.013 14.8 0.0 0.028 13.8 0.0 1.5 1 0 0 1 1 1 0 ThiF family HI0933_like PF03486.14 EXF75903.1 - 0.022 13.5 0.1 0.08 11.6 0.0 1.8 2 0 0 2 2 2 0 HI0933-like protein Pyr_redox_3 PF13738.6 EXF75903.1 - 0.033 13.4 0.3 3.5 6.8 0.2 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EXF75903.1 - 0.036 13.3 1.1 0.29 10.3 1.1 2.0 1 1 0 1 1 1 0 FAD binding domain NAD_binding_8 PF13450.6 EXF75903.1 - 0.13 12.5 0.0 0.43 10.9 0.0 2.0 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain HSP70 PF00012.20 EXF75904.1 - 1.8e-06 26.5 0.1 0.00036 18.8 0.0 2.1 2 0 0 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.13 EXF75904.1 - 0.024 13.5 0.1 0.039 12.8 0.1 1.3 1 0 0 1 1 1 0 MreB/Mbl protein DDR PF08841.10 EXF75904.1 - 0.029 13.4 0.2 0.039 12.9 0.2 1.1 1 0 0 1 1 1 0 Diol dehydratase reactivase ATPase-like domain Bap31_Bap29_C PF18035.1 EXF75905.1 - 0.013 15.5 4.2 0.026 14.5 4.2 1.5 1 0 0 1 1 1 0 Bap31/Bap29 cytoplasmic coiled-coil domain DUF3552 PF12072.8 EXF75905.1 - 0.086 12.2 3.2 0.14 11.6 3.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) ADH_zinc_N PF00107.26 EXF75906.1 - 9e-14 51.6 0.1 2.4e-13 50.2 0.0 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EXF75906.1 - 1.5e-06 28.1 0.4 5.1e-06 26.3 0.4 1.9 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 EXF75906.1 - 0.00013 23.0 0.0 0.00021 22.3 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase NmrA PF05368.13 EXF75907.1 - 7e-20 71.6 0.1 8.6e-20 71.3 0.1 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EXF75907.1 - 2e-14 53.9 0.0 3.2e-14 53.3 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 EXF75907.1 - 6.5e-06 26.4 0.1 2.4e-05 24.6 0.0 1.9 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain Epimerase PF01370.21 EXF75907.1 - 0.037 13.5 0.0 0.22 10.9 0.0 2.3 2 1 0 2 2 2 0 NAD dependent epimerase/dehydratase family NmrA PF05368.13 EXF75908.1 - 4.5e-35 121.3 0.0 9e-35 120.3 0.0 1.4 1 1 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EXF75908.1 - 7.3e-12 45.5 0.0 9.8e-12 45.1 0.0 1.1 1 0 0 1 1 1 1 NAD(P)H-binding TrkA_N PF02254.18 EXF75908.1 - 0.00016 21.9 0.1 0.00025 21.3 0.1 1.3 1 0 0 1 1 1 1 TrkA-N domain Epimerase PF01370.21 EXF75908.1 - 0.0003 20.3 0.1 0.00053 19.5 0.1 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EXF75908.1 - 0.013 14.5 0.0 0.017 14.2 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family FAD_binding_3 PF01494.19 EXF75909.1 - 3.6e-10 39.6 0.1 1.5e-09 37.6 0.1 1.8 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.24 EXF75909.1 - 0.002 17.8 0.1 0.0041 16.8 0.0 1.5 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EXF75909.1 - 0.0035 17.6 0.1 0.01 16.1 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_10 PF13460.6 EXF75910.1 - 7.3e-08 32.5 0.0 1.4e-07 31.6 0.0 1.6 1 1 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EXF75910.1 - 1.2e-07 31.6 0.0 1.7e-07 31.0 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family Epimerase PF01370.21 EXF75910.1 - 0.017 14.6 0.1 0.13 11.8 0.0 2.3 3 1 0 3 3 3 0 NAD dependent epimerase/dehydratase family Zn_clus PF00172.18 EXF75912.1 - 1.8e-06 28.0 9.4 1.8e-06 28.0 9.4 2.2 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EXF75912.1 - 0.0043 16.1 0.1 0.0084 15.2 0.1 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Fungal_trans_2 PF11951.8 EXF75913.1 - 2e-18 66.4 0.1 2.6e-11 43.0 0.0 2.3 2 0 0 2 2 2 2 Fungal specific transcription factor domain BMP2K_C PF15282.6 EXF75913.1 - 0.055 13.3 0.6 0.087 12.7 0.6 1.3 1 0 0 1 1 1 0 BMP-2-inducible protein kinase C-terminus HEPN_Toprim_N PF18871.1 EXF75913.1 - 0.1 12.5 0.0 0.17 11.8 0.0 1.3 1 0 0 1 1 1 0 HEPN/Toprim N-terminal domain 1 HpaP PF09483.10 EXF75913.1 - 0.13 12.5 0.1 0.46 10.8 0.0 1.9 2 0 0 2 2 2 0 Type III secretion protein (HpaP) Aa_trans PF01490.18 EXF75915.1 - 9e-54 182.7 41.8 1e-53 182.5 41.8 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Bunya_RdRp PF04196.12 EXF75916.1 - 0.29 9.4 0.0 0.4 9.0 0.0 1.1 1 0 0 1 1 1 0 Bunyavirus RNA dependent RNA polymerase DAP_epimerase PF01678.19 EXF75918.1 - 0.16 12.2 0.0 0.3 11.3 0.0 1.4 1 0 0 1 1 1 0 Diaminopimelate epimerase Anticodon_1 PF08264.13 EXF75918.1 - 0.26 11.3 0.9 0.5 10.3 0.1 1.8 2 1 0 2 2 2 0 Anticodon-binding domain of tRNA Fungal_trans PF04082.18 EXF75919.1 - 1.2e-14 54.0 0.0 2.1e-14 53.2 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain AUDH_Cupin PF18637.1 EXF75920.1 - 1.4e-61 207.1 4.8 2.1e-61 206.5 4.8 1.3 1 0 0 1 1 1 1 Aldos-2-ulose dehydratase/isomerase (AUDH) Cupin domain PBP3 PF18056.1 EXF75920.1 - 5.3e-29 100.5 0.0 8.4e-29 99.9 0.0 1.3 1 0 0 1 1 1 1 Penicillin Binding Protein 3 Domain VCBS PF13517.6 EXF75920.1 - 7.9e-06 26.4 1.8 0.6 10.7 0.0 4.4 5 0 0 5 5 5 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 EXF75920.1 - 0.0047 17.0 4.9 1.3 9.2 0.0 2.6 2 0 0 2 2 2 2 FG-GAP repeat Glyco_hydro_31 PF01055.26 EXF75921.1 - 1.8e-106 357.0 6.5 5.3e-106 355.4 6.5 1.8 1 1 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 EXF75921.1 - 2.6e-08 34.0 0.8 1e-07 32.2 0.8 2.1 1 0 0 1 1 1 1 Galactose mutarotase-like DUF5110 PF17137.4 EXF75921.1 - 6.6e-05 23.1 0.0 0.0057 16.9 0.0 2.9 2 0 0 2 2 2 1 Domain of unknown function (DUF5110) RPE65 PF03055.15 EXF75922.1 - 4.8e-112 375.5 0.0 5.7e-112 375.2 0.0 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein Tyrosinase PF00264.20 EXF75923.1 - 4.8e-51 174.2 1.7 7.1e-51 173.6 1.7 1.3 1 0 0 1 1 1 1 Common central domain of tyrosinase DiS_P_DiS PF06750.13 EXF75923.1 - 0.051 13.7 0.0 0.11 12.7 0.0 1.5 1 0 0 1 1 1 0 Bacterial Peptidase A24 N-terminal domain PPO1_DWL PF12142.8 EXF75923.1 - 0.15 11.9 0.0 0.36 10.6 0.0 1.6 1 0 0 1 1 1 0 Polyphenol oxidase middle domain Metallophos PF00149.28 EXF75924.1 - 3.7e-10 40.6 0.0 1.1e-09 39.1 0.0 1.8 1 1 1 2 2 2 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EXF75924.1 - 4.7e-05 23.6 0.0 0.00079 19.7 0.0 2.1 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase superfamily domain EstA_Ig_like PF18435.1 EXF75924.1 - 0.038 14.2 0.0 0.06 13.5 0.0 1.3 1 0 0 1 1 1 0 Esterase Ig-like N-terminal domain Fungal_trans PF04082.18 EXF75925.1 - 5.6e-33 114.1 0.0 1.1e-32 113.2 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF75925.1 - 0.00016 21.7 1.2 0.00032 20.7 1.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CCDC53 PF10152.9 EXF75925.1 - 0.63 10.4 3.4 18 5.7 0.0 2.2 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex HORMA PF02301.18 EXF75926.1 - 3e-34 118.5 0.0 4e-34 118.1 0.0 1.2 1 0 0 1 1 1 1 HORMA domain ATG101 PF07855.12 EXF75926.1 - 0.0003 20.8 0.4 0.0011 19.0 0.4 1.9 1 1 0 1 1 1 1 Autophagy-related protein 101 BUD22 PF09073.10 EXF75926.1 - 0.00054 19.4 0.9 0.00077 18.9 0.9 1.1 1 0 0 1 1 1 1 BUD22 DUF3530 PF12048.8 EXF75926.1 - 0.013 14.9 1.1 0.097 12.1 0.6 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3530) DUF2660 PF10859.8 EXF75926.1 - 0.05 14.1 0.1 0.11 13.0 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2660) Med21 PF11221.8 EXF75926.1 - 0.085 13.1 0.3 0.085 13.1 0.3 1.7 2 0 0 2 2 2 0 Subunit 21 of Mediator complex Stirrup PF09061.6 EXF75926.1 - 0.11 12.7 0.0 0.88 9.8 0.0 2.1 2 0 0 2 2 2 0 Stirrup FlaG PF03646.15 EXF75926.1 - 2.3 8.4 9.0 21 5.3 0.9 3.2 3 0 0 3 3 3 0 FlaG protein UCH PF00443.29 EXF75927.1 - 5.1e-36 124.5 0.0 8.9e-36 123.7 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UBA PF00627.31 EXF75927.1 - 2.2e-23 81.8 0.4 1.3e-11 44.2 0.3 2.7 2 0 0 2 2 2 2 UBA/TS-N domain zf-UBP_var PF17807.1 EXF75927.1 - 7.3e-23 80.1 1.0 1.4e-21 76.0 0.0 2.5 2 0 0 2 2 2 1 Variant UBP zinc finger zf-UBP PF02148.19 EXF75927.1 - 9.4e-23 80.3 9.7 4.2e-19 68.6 2.2 3.0 2 0 0 2 2 2 2 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.6 EXF75927.1 - 2.1e-17 63.7 0.2 7.7e-15 55.3 0.0 3.6 3 1 0 3 3 3 1 Ubiquitin carboxyl-terminal hydrolase UBA_4 PF14555.6 EXF75927.1 - 0.055 13.3 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 UBA-like domain CUE PF02845.16 EXF75927.1 - 0.089 12.5 0.0 0.91 9.3 0.0 2.4 2 0 0 2 2 2 0 CUE domain UBA_3 PF09288.10 EXF75927.1 - 0.1 12.4 0.0 1.2 9.0 0.0 2.7 3 0 0 3 3 3 0 Fungal ubiquitin-associated domain NifU_N PF01592.16 EXF75928.1 - 3.3e-52 176.0 0.0 4.5e-52 175.5 0.0 1.2 1 0 0 1 1 1 1 NifU-like N terminal domain adh_short PF00106.25 EXF75929.1 - 6.4e-20 71.4 0.0 2.6e-15 56.4 0.0 2.3 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EXF75929.1 - 7.7e-12 45.3 0.1 5.6e-08 32.6 0.0 2.4 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF75929.1 - 7.1e-08 32.6 0.1 3.5e-07 30.3 0.1 2.0 2 0 0 2 2 2 1 KR domain Epimerase PF01370.21 EXF75929.1 - 0.013 14.9 0.1 0.023 14.2 0.1 1.5 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EXF75929.1 - 0.028 14.3 0.2 0.1 12.5 0.2 1.9 1 1 0 1 1 1 0 NAD(P)H-binding NADHdeh_related PF10125.9 EXF75930.1 - 0.023 14.1 2.3 0.11 11.9 0.4 2.2 2 0 0 2 2 2 0 NADH dehydrogenase I, subunit N related protein Saf_2TM PF18303.1 EXF75930.1 - 0.087 12.4 0.5 0.18 11.4 0.5 1.5 1 0 0 1 1 1 0 SAVED-fused 2TM effector domain DEAD PF00270.29 EXF75931.1 - 8.7e-51 172.2 0.0 3.5e-50 170.2 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EXF75931.1 - 4.6e-34 117.1 0.1 1.3e-30 106.0 0.0 2.9 3 0 0 3 3 3 2 Helicase conserved C-terminal domain UTP25 PF06862.12 EXF75931.1 - 0.0095 14.8 0.1 0.045 12.5 0.0 2.1 2 1 0 2 2 2 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 Zip PF02535.22 EXF75931.1 - 0.41 9.8 5.5 0.57 9.3 5.5 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 EXF75931.1 - 0.77 8.5 13.4 1.2 7.9 13.4 1.2 1 0 0 1 1 1 0 Presenilin CMS1 PF14617.6 EXF75931.1 - 0.94 8.8 0.0 0.94 8.8 0.0 3.6 2 1 1 3 3 3 0 U3-containing 90S pre-ribosomal complex subunit BSP_II PF05432.11 EXF75931.1 - 1.2 8.7 20.4 1.9 8.1 20.4 1.2 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) AAA_11 PF13086.6 EXF75931.1 - 3.5 7.4 14.9 7.4 6.3 14.9 1.5 1 0 0 1 1 1 0 AAA domain LYRIC PF15686.5 EXF75931.1 - 4 6.9 31.3 7.5 6.0 31.3 1.4 1 0 0 1 1 1 0 Lysine-rich CEACAM1 co-isolated protein family NPR3 PF03666.13 EXF75931.1 - 4.2 6.0 17.0 6.3 5.5 17.0 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 TAF4 PF05236.14 EXF75931.1 - 6.4 6.4 23.7 11 5.6 23.7 1.4 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family DUF4551 PF15087.6 EXF75931.1 - 6.6 5.4 9.7 9.7 4.9 9.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Seryl_tRNA_N PF02403.22 EXF75931.1 - 7.7 6.8 22.3 18 5.6 22.3 1.7 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain DUF966 PF06136.13 EXF75931.1 - 9.7 5.8 17.7 18 4.9 17.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Rft-1 PF04506.13 EXF75932.1 - 1.7e-148 495.6 11.5 1.9e-148 495.4 11.5 1.0 1 0 0 1 1 1 1 Rft protein Urb2 PF10441.9 EXF75932.1 - 0.013 15.4 0.4 0.026 14.5 0.4 1.5 1 0 0 1 1 1 0 Urb2/Npa2 family Polysacc_synt_3 PF13440.6 EXF75932.1 - 0.016 14.5 0.8 0.016 14.5 0.8 3.2 2 1 1 3 3 3 0 Polysaccharide biosynthesis protein DivIVA PF05103.13 EXF75933.1 - 0.64 10.1 27.7 6.5 6.9 1.2 3.6 2 1 1 3 3 3 0 DivIVA protein DUF2046 PF09755.9 EXF75933.1 - 1.4 8.1 25.8 0.9 8.7 23.7 1.8 2 0 0 2 2 2 0 Uncharacterized conserved protein H4 (DUF2046) Ribosomal_L18 PF17135.4 EXF75937.1 - 5.2e-92 306.4 3.7 6e-92 306.2 3.7 1.0 1 0 0 1 1 1 1 Ribosomal protein 60S L18 and 50S L18e Ribosomal_L27A PF00828.19 EXF75937.1 - 0.0019 18.8 0.1 0.0019 18.8 0.1 2.0 2 1 0 2 2 2 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Mito_carr PF00153.27 EXF75938.1 - 3.4e-72 238.4 3.6 6.9e-24 83.6 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 EXF75938.1 - 0.00014 21.1 0.1 0.0044 16.2 0.0 2.8 2 1 1 3 3 3 1 Gammaproteobacterial serine protease RRM_1 PF00076.22 EXF75939.1 - 7.8e-12 44.8 0.0 1.1e-11 44.3 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EXF75939.1 - 0.00015 21.6 0.0 0.00022 21.1 0.0 1.3 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif MBOAT PF03062.19 EXF75940.1 - 6.2e-43 147.5 22.1 6.2e-43 147.5 22.1 2.4 2 1 0 2 2 2 1 MBOAT, membrane-bound O-acyltransferase family MBOAT_2 PF13813.6 EXF75940.1 - 3e-06 27.4 4.5 7.3e-06 26.2 4.5 1.6 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family Med3 PF11593.8 EXF75940.1 - 0.055 12.7 4.6 0.091 11.9 4.6 1.3 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal CH PF00307.31 EXF75941.1 - 1.2e-64 215.2 0.0 5.6e-17 61.9 0.0 4.2 4 0 0 4 4 4 4 Calponin homology (CH) domain EF-hand_7 PF13499.6 EXF75941.1 - 3.1e-06 27.6 0.2 4.5e-05 23.8 0.0 2.7 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 EXF75941.1 - 1.5e-05 24.2 0.5 1.6 8.4 0.1 3.6 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 EXF75941.1 - 0.057 13.4 0.2 6 7.1 0.0 3.3 3 0 0 3 3 3 0 EF-hand domain Ank_2 PF12796.7 EXF75942.1 - 0.00055 20.5 0.1 0.0019 18.7 0.0 1.9 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) zf-RING_2 PF13639.6 EXF75942.1 - 0.0044 17.3 2.6 0.0044 17.3 2.6 1.6 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_4 PF15227.6 EXF75942.1 - 0.048 13.8 3.4 0.11 12.7 3.4 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 EXF75942.1 - 0.96 9.5 6.0 1.8 8.6 5.8 1.7 1 1 0 1 1 1 0 RING-type zinc-finger DDHD PF02862.17 EXF75943.1 - 1.2e-63 215.3 0.0 1.2e-63 215.3 0.0 2.8 3 1 0 3 3 3 1 DDHD domain Abhydrolase_6 PF12697.7 EXF75943.1 - 0.058 14.0 0.0 0.11 13.1 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase family LIDHydrolase PF10230.9 EXF75943.1 - 0.062 12.8 0.0 0.16 11.5 0.0 1.6 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase Lipase_3 PF01764.25 EXF75943.1 - 0.13 12.2 0.0 0.29 11.0 0.0 1.5 1 0 0 1 1 1 0 Lipase (class 3) RNA_pol_Rpb1_1 PF04997.12 EXF75944.1 - 3e-84 283.0 0.1 5.2e-84 282.2 0.1 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_5 PF04998.17 EXF75944.1 - 2.4e-78 263.2 0.1 4.1e-78 262.5 0.1 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 EXF75944.1 - 3.4e-73 245.3 0.0 6.8e-73 244.3 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 EXF75944.1 - 5.1e-40 137.0 0.0 1.4e-39 135.6 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 EXF75944.1 - 2.1e-29 101.6 0.1 6.6e-29 100.0 0.1 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 Tannase PF07519.11 EXF75945.1 - 7.8e-105 351.5 1.5 1.1e-104 351.0 1.5 1.1 1 0 0 1 1 1 1 Tannase and feruloyl esterase SRAP PF02586.14 EXF75945.1 - 2.5e-75 252.8 0.0 4e-75 252.1 0.0 1.3 1 0 0 1 1 1 1 SOS response associated peptidase (SRAP) bZIP_1 PF00170.21 EXF75946.1 - 3.5e-05 23.8 11.2 5.5e-05 23.2 11.2 1.2 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EXF75946.1 - 0.049 13.7 9.2 0.086 12.9 9.2 1.4 1 0 0 1 1 1 0 Basic region leucine zipper Macoilin PF09726.9 EXF75946.1 - 0.21 10.1 5.9 0.26 9.8 5.9 1.0 1 0 0 1 1 1 0 Macoilin family CDC45 PF02724.14 EXF75946.1 - 0.51 8.6 5.0 0.61 8.3 5.0 1.1 1 0 0 1 1 1 0 CDC45-like protein NRBF2 PF08961.10 EXF75946.1 - 0.96 9.0 5.9 0.19 11.3 2.0 1.7 2 0 0 2 2 2 0 Nuclear receptor-binding factor 2, autophagy regulator Glyco_hydro_61 PF03443.14 EXF75947.1 - 2.2e-48 164.9 0.0 2.5e-48 164.8 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 Glyco_hydro_61 PF03443.14 EXF75948.1 - 3.6e-42 144.6 0.1 4.7e-42 144.3 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 Sugar_tr PF00083.24 EXF75949.1 - 6.6e-121 404.3 22.1 7.5e-121 404.1 22.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF75949.1 - 2.2e-18 66.3 30.4 2.2e-18 66.3 30.4 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily TPR_19 PF14559.6 EXF75949.1 - 0.14 12.7 0.0 0.27 11.8 0.0 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat ADH_N PF08240.12 EXF75951.1 - 4.5e-24 84.4 1.6 8.2e-24 83.6 1.6 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_N_assoc PF13823.6 EXF75951.1 - 1.3e-09 37.8 1.5 1.3e-09 37.8 1.5 1.8 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-associated ADH_zinc_N PF00107.26 EXF75951.1 - 7.9e-08 32.4 0.0 1e-05 25.5 0.0 2.6 2 0 0 2 2 2 2 Zinc-binding dehydrogenase Oxidored_FMN PF00724.20 EXF75953.1 - 1.4e-27 96.9 0.0 1e-26 94.0 0.0 2.0 1 1 0 2 2 2 1 NADH:flavin oxidoreductase / NADH oxidase family Fungal_trans PF04082.18 EXF75954.1 - 3.9e-21 75.3 0.0 6.3e-21 74.6 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF75954.1 - 5.6e-08 32.8 7.3 5.6e-08 32.8 7.3 2.1 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MSG PF02349.15 EXF75954.1 - 0.045 13.9 2.9 1.3 9.2 0.0 2.3 2 0 0 2 2 2 0 Major surface glycoprotein Peptidase_M24 PF00557.24 EXF75954.1 - 0.16 11.7 0.0 0.26 10.9 0.0 1.3 1 0 0 1 1 1 0 Metallopeptidase family M24 Pyr_redox_2 PF07992.14 EXF75955.1 - 1.6e-50 172.0 3.3 2.2e-50 171.6 3.3 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Rieske PF00355.26 EXF75955.1 - 2.1e-14 53.2 0.0 5e-14 52.0 0.0 1.6 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Pyr_redox PF00070.27 EXF75955.1 - 1.9e-13 50.8 1.2 1.9e-13 50.8 1.2 2.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Reductase_C PF14759.6 EXF75955.1 - 2.9e-06 27.8 0.0 7.8e-06 26.4 0.0 1.8 1 0 0 1 1 1 1 Reductase C-terminal Rieske_2 PF13806.6 EXF75955.1 - 0.00021 21.2 0.0 0.00073 19.4 0.0 1.9 2 0 0 2 2 2 1 Rieske-like [2Fe-2S] domain K_oxygenase PF13434.6 EXF75955.1 - 0.00096 18.4 0.0 0.76 8.8 0.0 2.5 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 EXF75955.1 - 0.019 14.9 3.4 2.2 8.3 0.0 3.1 3 0 0 3 3 3 0 FAD-NAD(P)-binding DUF1188 PF06690.11 EXF75955.1 - 0.025 14.1 0.1 0.037 13.6 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1188) FIST PF08495.10 EXF75955.1 - 0.083 12.9 0.3 0.37 10.8 0.0 2.1 2 0 0 2 2 2 0 FIST N domain FAD_binding_3 PF01494.19 EXF75956.1 - 8.5e-62 209.4 0.1 9e-61 206.0 0.1 2.3 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.24 EXF75956.1 - 5.5e-07 29.5 0.0 0.0042 16.7 0.0 2.4 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox PF00070.27 EXF75956.1 - 0.015 15.8 0.0 0.6 10.7 0.0 2.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EXF75956.1 - 0.027 14.7 0.0 0.07 13.4 0.0 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EXF75956.1 - 0.13 11.5 0.0 2.4 7.3 0.0 2.4 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase GFO_IDH_MocA PF01408.22 EXF75957.1 - 6.4e-24 85.1 0.4 1.8e-23 83.7 0.0 1.9 2 0 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold NAD_binding_3 PF03447.16 EXF75957.1 - 1.5e-05 25.6 0.1 7.9e-05 23.3 0.0 2.0 2 0 0 2 2 2 1 Homoserine dehydrogenase, NAD binding domain Spermine_synth PF01564.17 EXF75957.1 - 0.15 11.4 0.0 0.28 10.6 0.0 1.4 1 0 0 1 1 1 0 Spermine/spermidine synthase domain Iso_dh PF00180.20 EXF75958.1 - 1.1e-98 330.7 0.0 1.3e-98 330.4 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Phage_30_3 PF08010.11 EXF75958.1 - 0.0067 16.2 0.0 0.014 15.2 0.0 1.4 1 0 0 1 1 1 1 Bacteriophage protein GP30.3 Sec5 PF15469.6 EXF75959.1 - 6.7e-40 136.9 0.0 2.2e-39 135.2 0.0 2.0 2 0 0 2 2 2 1 Exocyst complex component Sec5 Vps51 PF08700.11 EXF75959.1 - 0.00026 21.0 2.3 0.00046 20.2 0.1 2.6 2 0 0 2 2 2 1 Vps51/Vps67 Sec15 PF04091.12 EXF75959.1 - 0.0054 16.2 0.1 0.01 15.3 0.1 1.3 1 0 0 1 1 1 1 Exocyst complex subunit Sec15-like Zn_clus PF00172.18 EXF75960.1 - 0.12 12.6 7.7 0.3 11.3 7.7 1.7 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Glyco_hydro_92 PF07971.12 EXF75961.1 - 1e-134 450.0 0.1 1.2e-134 449.7 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 Glyco_hydro_92N PF17678.1 EXF75961.1 - 3.8e-49 167.7 2.6 8.4e-49 166.6 2.5 1.6 2 0 0 2 2 2 1 Glycosyl hydrolase family 92 N-terminal domain Acetyltransf_1 PF00583.25 EXF75961.1 - 0.053 13.8 0.0 0.15 12.3 0.0 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Solute_trans_a PF03619.16 EXF75962.1 - 1.9e-99 332.5 9.4 2.3e-99 332.2 9.4 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha GTP_EFTU PF00009.27 EXF75964.1 - 9.3e-66 221.1 0.4 9.3e-66 221.1 0.4 1.7 2 0 0 2 2 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 EXF75964.1 - 5.6e-32 110.1 0.0 1.4e-31 108.7 0.0 1.8 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_C PF00679.24 EXF75964.1 - 1.9e-22 79.1 0.0 6.1e-22 77.5 0.0 1.9 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 EXF75964.1 - 1.6e-12 47.6 1.2 3.1e-12 46.7 0.1 2.1 2 0 0 2 2 1 1 Elongation factor Tu domain 2 EFG_II PF14492.6 EXF75964.1 - 1.3e-11 44.4 0.0 3.8e-11 42.9 0.0 1.8 1 0 0 1 1 1 1 Elongation Factor G, domain II Nup35_RRM_2 PF14605.6 EXF75964.1 - 1.1e-09 38.2 0.0 0.0015 18.5 0.0 2.6 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif RRM_1 PF00076.22 EXF75964.1 - 5.7e-08 32.5 0.5 1.8e-06 27.7 0.0 3.2 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCCH PF00642.24 EXF75964.1 - 1.7e-05 24.6 2.9 3e-05 23.8 2.9 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EXF75964.1 - 0.00042 20.3 4.6 0.00076 19.4 4.6 1.5 1 0 0 1 1 1 1 Zinc finger domain MMR_HSR1 PF01926.23 EXF75964.1 - 0.00066 19.7 0.4 0.0018 18.3 0.4 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase Borrelia_P83 PF05262.11 EXF75964.1 - 0.0023 16.5 5.9 0.0042 15.7 5.9 1.4 1 0 0 1 1 1 1 Borrelia P83/100 protein DNA_mis_repair PF01119.19 EXF75964.1 - 0.029 14.1 0.0 0.86 9.3 0.0 2.4 2 0 0 2 2 2 0 DNA mismatch repair protein, C-terminal domain PHM7_cyt PF14703.6 EXF75964.1 - 0.068 13.4 0.0 0.068 13.4 0.0 3.2 3 0 0 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter PWI PF01480.17 EXF75964.1 - 0.07 13.4 0.0 0.25 11.7 0.0 1.9 1 0 0 1 1 1 0 PWI domain PduV-EutP PF10662.9 EXF75964.1 - 0.14 11.8 0.2 0.41 10.4 0.1 1.7 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Atg14 PF10186.9 EXF75964.1 - 0.19 10.8 2.0 0.34 10.0 2.0 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 RRM_3 PF08777.11 EXF75964.1 - 0.4 10.7 3.9 2.4 8.2 0.5 3.1 2 1 1 3 3 3 0 RNA binding motif Torus PF16131.5 EXF75964.1 - 0.64 10.7 3.1 0.36 11.5 0.1 2.1 2 0 0 2 2 1 0 Torus domain zf-CCCH_4 PF18044.1 EXF75964.1 - 0.96 9.3 4.6 1.7 8.6 4.6 1.4 1 0 0 1 1 1 0 CCCH-type zinc finger DUF4210 PF13915.6 EXF75965.1 - 6.9e-33 113.1 0.0 1.7e-32 111.8 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4210) Chromosome_seg PF13889.6 EXF75965.1 - 1.6e-22 79.4 0.4 3.2e-22 78.5 0.4 1.5 1 0 0 1 1 1 1 Chromosome segregation during meiosis Cutinase PF01083.22 EXF75966.1 - 6.4e-41 140.2 0.0 8.5e-41 139.9 0.0 1.1 1 0 0 1 1 1 1 Cutinase DUF2974 PF11187.8 EXF75966.1 - 0.0056 16.3 0.0 0.0087 15.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2974) Abhydrolase_8 PF06259.12 EXF75966.1 - 0.012 15.3 0.1 0.022 14.4 0.1 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase PE-PPE PF08237.11 EXF75966.1 - 0.014 14.9 0.0 0.024 14.2 0.0 1.3 1 0 0 1 1 1 0 PE-PPE domain Lipase_3 PF01764.25 EXF75966.1 - 0.021 14.7 0.0 0.033 14.0 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) Palm_thioest PF02089.15 EXF75966.1 - 0.089 12.6 0.0 0.13 12.1 0.0 1.2 1 0 0 1 1 1 0 Palmitoyl protein thioesterase PPR_2 PF13041.6 EXF75967.1 - 1.7e-16 60.1 0.6 1.4e-06 28.4 0.1 6.9 6 1 1 7 7 7 3 PPR repeat family PPR PF01535.20 EXF75967.1 - 3.2e-12 45.8 2.2 0.0027 17.8 0.0 7.0 7 0 0 7 7 7 2 PPR repeat PPR_3 PF13812.6 EXF75967.1 - 2.9e-08 33.7 0.0 0.00047 20.2 0.0 4.2 3 1 0 4 4 4 1 Pentatricopeptide repeat domain PPR_1 PF12854.7 EXF75967.1 - 0.00024 20.7 0.0 1 9.1 0.0 5.0 6 0 0 6 6 6 1 PPR repeat TPR_14 PF13428.6 EXF75967.1 - 0.00041 20.9 7.3 12 7.0 0.0 6.9 7 1 1 8 8 6 1 Tetratricopeptide repeat PPR_long PF17177.4 EXF75967.1 - 0.016 14.6 0.1 0.35 10.2 0.1 2.5 1 1 0 1 1 1 0 Pentacotripeptide-repeat region of PRORP TPR_2 PF07719.17 EXF75967.1 - 0.055 13.6 8.4 2.4 8.5 0.4 4.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 EXF75967.1 - 0.36 11.1 1.7 4.1 7.8 0.0 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat FRB_dom PF08771.11 EXF75967.1 - 0.44 11.0 2.7 52 4.3 0.1 4.2 5 0 0 5 5 4 0 FKBP12-rapamycin binding domain TPR_1 PF00515.28 EXF75967.1 - 0.45 10.4 3.9 13 5.8 0.1 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat BTAD PF03704.17 EXF75967.1 - 1.1 9.7 9.5 5.9 7.3 0.0 3.7 3 0 0 3 3 3 0 Bacterial transcriptional activator domain TPR_10 PF13374.6 EXF75967.1 - 1.1 9.2 3.5 6.6 6.8 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat SRP68 PF16969.5 EXF75968.1 - 8.7e-205 681.9 14.8 9.8e-205 681.8 14.8 1.0 1 0 0 1 1 1 1 RNA-binding signal recognition particle 68 Rab_bind PF16704.5 EXF75968.1 - 0.0071 16.4 2.4 0.11 12.5 0.1 3.2 3 0 0 3 3 3 1 Rab binding domain P4Ha_N PF08336.11 EXF75968.1 - 0.029 14.4 0.4 0.12 12.4 0.1 2.3 2 0 0 2 2 2 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region CENP-O PF09496.10 EXF75968.1 - 0.031 14.3 0.7 0.031 14.3 0.7 2.6 3 0 0 3 3 3 0 Cenp-O kinetochore centromere component DUF755 PF05501.11 EXF75968.1 - 0.16 12.2 0.1 0.16 12.2 0.1 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF755) Mis14 PF08641.12 EXF75968.1 - 0.62 10.4 6.1 0.53 10.6 0.1 3.4 3 1 0 3 3 3 0 Kinetochore protein Mis14 like HSP70 PF00012.20 EXF75969.1 - 8.6e-267 886.2 15.6 9.9e-267 886.0 15.6 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EXF75969.1 - 1e-15 57.4 4.1 9.4e-14 51.0 0.8 2.4 2 0 0 2 2 2 2 MreB/Mbl protein FGGY_C PF02782.16 EXF75969.1 - 0.00044 20.0 0.0 0.0013 18.5 0.0 1.9 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain Ploopntkinase3 PF18751.1 EXF75969.1 - 0.029 14.3 0.2 2.3 8.1 0.0 2.4 1 1 1 2 2 2 0 P-loop Nucleotide Kinase3 ApoLp-III PF07464.11 EXF75969.1 - 7.3 6.7 9.4 1.1 9.4 3.2 2.6 2 1 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) DUF2415 PF10313.9 EXF75970.1 - 2.2e-13 49.9 0.0 5.8e-13 48.5 0.0 1.8 1 0 0 1 1 1 1 Uncharacterised protein domain (DUF2415) ANAPC4_WD40 PF12894.7 EXF75970.1 - 0.00042 20.5 0.0 0.81 10.0 0.0 3.9 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain DAO PF01266.24 EXF75971.1 - 1.2e-59 202.7 3.1 1.4e-59 202.5 3.1 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EXF75971.1 - 4.5e-05 23.6 0.0 9.9e-05 22.5 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 EXF75971.1 - 0.0076 15.5 0.0 0.015 14.5 0.0 1.4 1 0 0 1 1 1 1 Thi4 family DUF676 PF05057.14 EXF75972.1 - 1.3e-42 145.8 0.2 2.8e-27 95.7 0.0 3.2 2 1 1 3 3 3 3 Putative serine esterase (DUF676) PGAP1 PF07819.13 EXF75972.1 - 0.11 12.2 0.0 0.2 11.3 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein IBR PF01485.21 EXF75973.1 - 2.9e-10 40.2 47.1 9.9e-07 28.9 13.3 3.6 3 1 0 3 3 3 2 IBR domain, a half RING-finger domain zf-RING_2 PF13639.6 EXF75973.1 - 0.0014 18.9 7.0 0.0014 18.9 7.0 3.6 3 0 0 3 3 3 1 Ring finger domain zf-RING_UBOX PF13445.6 EXF75973.1 - 0.0024 17.8 8.8 0.0095 15.9 8.8 2.1 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_11 PF17123.5 EXF75973.1 - 0.035 13.9 0.4 0.035 13.9 0.4 2.8 3 0 0 3 3 3 0 RING-like zinc finger DUF2158 PF09926.9 EXF75973.1 - 0.22 11.3 0.3 0.53 10.1 0.3 1.5 1 0 0 1 1 1 0 Uncharacterized small protein (DUF2158) eIF3_subunit PF08597.10 EXF75973.1 - 0.24 11.3 19.4 0.46 10.4 19.4 1.4 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit GREB1 PF15782.5 EXF75973.1 - 2.1 5.4 20.3 2.8 4.9 20.3 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer TFIIF_alpha PF05793.12 EXF75973.1 - 6.9 5.1 32.8 12 4.3 32.8 1.4 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Zn_clus PF00172.18 EXF75974.1 - 1.6e-09 37.7 7.9 1.6e-09 37.7 7.9 1.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Lactonase PF10282.9 EXF75975.1 - 5.1e-84 282.5 0.0 6.2e-84 282.2 0.0 1.0 1 0 0 1 1 1 1 Lactonase, 7-bladed beta-propeller PEMT PF04191.13 EXF75976.1 - 2.9e-56 188.4 10.3 1.4e-34 118.7 1.7 2.6 2 0 0 2 2 2 2 Phospholipid methyltransferase HECW_N PF16562.5 EXF75976.1 - 0.0048 16.7 0.1 0.016 15.0 0.0 1.8 2 0 0 2 2 2 1 N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2 SKICH PF17751.1 EXF75976.1 - 0.14 12.7 0.1 1.9 9.1 0.1 2.3 1 1 0 1 1 1 0 SKICH domain DUF863 PF05904.11 EXF75977.1 - 0.0088 14.6 0.0 0.0097 14.4 0.0 1.0 1 0 0 1 1 1 1 Plant protein of unknown function (DUF863) DUF3391 PF11871.8 EXF75977.1 - 2.6 8.6 8.4 0.62 10.6 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3391) eIF3g PF12353.8 EXF75978.1 - 2.8e-44 150.5 1.6 5.2e-44 149.6 1.6 1.4 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit G RRM_1 PF00076.22 EXF75978.1 - 5.9e-16 58.1 0.1 9.9e-16 57.3 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCCH_7 PF18586.1 EXF75978.1 - 0.021 15.2 0.2 0.04 14.2 0.2 1.4 1 0 0 1 1 1 0 Chromatin remodeling factor Mit1 C-terminal Zn finger 1 RRM_occluded PF16842.5 EXF75978.1 - 0.033 14.1 0.0 0.078 12.8 0.0 1.6 1 0 0 1 1 1 0 Occluded RNA-recognition motif PH PF00169.29 EXF75979.1 - 0.17 12.4 0.0 0.42 11.1 0.0 1.8 1 1 0 1 1 1 0 PH domain Pox_A_type_inc PF04508.12 EXF75980.1 - 0.0024 17.6 1.1 0.0058 16.4 1.1 1.7 1 0 0 1 1 1 1 Viral A-type inclusion protein repeat PriC PF07445.12 EXF75980.1 - 0.0065 16.4 0.4 0.0065 16.4 0.4 1.7 2 0 0 2 2 2 1 Primosomal replication protein priC Shugoshin_N PF07558.11 EXF75980.1 - 0.021 14.7 0.1 0.051 13.5 0.1 1.7 1 0 0 1 1 1 0 Shugoshin N-terminal coiled-coil region SlyX PF04102.12 EXF75980.1 - 0.13 12.9 11.5 3.7 8.2 6.3 2.5 2 0 0 2 2 2 0 SlyX SKA2 PF16740.5 EXF75980.1 - 3.1 7.6 8.1 1.6 8.6 4.3 2.1 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 2 DivIC PF04977.15 EXF75980.1 - 5.3 6.9 7.6 2.8 7.8 0.1 2.3 2 0 0 2 2 2 0 Septum formation initiator FAM184 PF15665.5 EXF75983.1 - 4.5 7.0 23.4 25 4.6 19.5 3.3 1 1 1 2 2 2 0 Family with sequence similarity 184, A and B G-7-MTase PF12803.7 EXF75983.1 - 4.6 6.3 5.2 25 3.9 5.3 1.9 1 1 0 1 1 1 0 mRNA (guanine-7-)methyltransferase (G-7-MTase) DUF724 PF05266.14 EXF75984.1 - 0.24 11.2 2.6 0.29 10.9 2.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF724) FKBP_C PF00254.28 EXF75987.1 - 2.3e-27 95.2 0.1 2.8e-27 94.9 0.1 1.1 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase ThiF PF00899.21 EXF75988.1 - 1.6e-112 374.8 0.0 8.8e-76 254.5 0.0 2.6 2 1 0 2 2 2 2 ThiF family UBA_e1_thiolCys PF10585.9 EXF75988.1 - 5.9e-93 311.4 0.7 1.1e-92 310.6 0.7 1.5 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site E1_FCCH PF16190.5 EXF75988.1 - 1.7e-31 108.2 0.1 5.3e-31 106.6 0.1 1.9 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 FCCH domain E1_UFD PF09358.10 EXF75988.1 - 2.9e-31 108.0 0.1 7e-31 106.8 0.1 1.7 1 0 0 1 1 1 1 Ubiquitin fold domain E1_4HB PF16191.5 EXF75988.1 - 2.6e-24 85.2 0.7 2.6e-24 85.2 0.7 1.9 2 0 0 2 2 2 1 Ubiquitin-activating enzyme E1 four-helix bundle GST_N_2 PF13409.6 EXF75988.1 - 4.7e-18 65.3 0.0 1.5e-17 63.6 0.0 2.0 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EXF75988.1 - 6.4e-14 51.7 0.0 2e-13 50.1 0.0 2.0 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EXF75988.1 - 1.3e-05 25.5 0.2 0.062 13.7 0.0 2.5 2 0 0 2 2 2 2 Glutathione S-transferase, N-terminal domain Ribosomal_L18 PF17135.4 EXF75988.1 - 0.1 12.0 0.3 0.17 11.3 0.3 1.3 1 0 0 1 1 1 0 Ribosomal protein 60S L18 and 50S L18e Chitin_synth_2 PF03142.15 EXF75989.1 - 2e-247 822.0 2.2 3.1e-247 821.4 2.2 1.2 1 0 0 1 1 1 1 Chitin synthase Myosin_head PF00063.21 EXF75989.1 - 2.6e-75 254.0 0.0 7.8e-74 249.1 0.0 2.1 1 1 0 1 1 1 1 Myosin head (motor domain) DEK_C PF08766.11 EXF75989.1 - 5e-17 61.6 0.0 2.4e-16 59.4 0.1 2.2 2 0 0 2 2 2 1 DEK C terminal domain Cyt-b5 PF00173.28 EXF75989.1 - 1.9e-14 53.5 0.4 2.2e-11 43.7 0.1 3.3 3 0 0 3 3 3 1 Cytochrome b5-like Heme/Steroid binding domain Glyco_trans_2_3 PF13632.6 EXF75989.1 - 4.4e-11 43.1 4.7 4.4e-11 43.1 4.7 1.9 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 EXF75989.1 - 1.7e-09 38.0 0.1 2.9e-08 33.9 0.1 2.4 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 EXF75989.1 - 1.3e-05 25.1 0.0 0.017 15.0 0.0 2.6 2 0 0 2 2 2 2 Glycosyl transferase family 2 AAA_16 PF13191.6 EXF75989.1 - 0.037 14.4 0.6 0.18 12.2 0.1 2.4 2 0 0 2 2 2 0 AAA ATPase domain RsgA_GTPase PF03193.16 EXF75989.1 - 0.057 13.3 0.0 0.16 11.9 0.0 1.7 1 0 0 1 1 1 0 RsgA GTPase AAA_29 PF13555.6 EXF75989.1 - 0.063 13.0 0.1 0.17 11.6 0.1 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 EXF75989.1 - 0.078 13.1 0.1 3.6 7.7 0.1 3.0 2 1 0 2 2 2 0 50S ribosome-binding GTPase DUF2157 PF09925.9 EXF75989.1 - 0.097 12.5 0.2 0.28 11.0 0.2 1.7 1 0 0 1 1 1 0 Predicted membrane protein (DUF2157) ABC_tran PF00005.27 EXF75989.1 - 0.11 13.0 2.3 0.19 12.2 0.1 2.3 2 0 0 2 2 2 0 ABC transporter Chitin_synth_2 PF03142.15 EXF75990.1 - 1.1e-227 756.8 0.1 1.6e-227 756.3 0.1 1.2 1 0 0 1 1 1 1 Chitin synthase Glyco_trans_2_3 PF13632.6 EXF75990.1 - 4.5e-16 59.4 1.9 1e-15 58.2 1.9 1.6 1 0 0 1 1 1 1 Glycosyl transferase family group 2 Cyt-b5 PF00173.28 EXF75990.1 - 8.6e-15 54.6 0.5 4.2e-09 36.4 0.0 3.0 2 0 0 2 2 2 2 Cytochrome b5-like Heme/Steroid binding domain DEK_C PF08766.11 EXF75990.1 - 2e-14 53.3 0.2 1.1e-13 50.8 0.3 2.1 2 0 0 2 2 2 1 DEK C terminal domain Glyco_tranf_2_3 PF13641.6 EXF75990.1 - 8e-11 42.3 0.0 3.6e-10 40.1 0.0 1.9 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Myosin_head PF00063.21 EXF75990.1 - 3e-07 29.1 0.0 1.4e-06 26.8 0.0 1.8 1 1 0 1 1 1 1 Myosin head (motor domain) Glyco_transf_21 PF13506.6 EXF75990.1 - 0.00025 20.6 0.0 0.0023 17.4 0.0 2.2 2 0 0 2 2 2 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.26 EXF75990.1 - 0.0013 18.6 0.0 0.23 11.2 0.0 2.5 2 0 0 2 2 2 1 Glycosyl transferase family 2 BCDHK_Adom3 PF10436.9 EXF75991.1 - 2.1e-48 164.2 0.0 2.9e-48 163.8 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 EXF75991.1 - 1.5e-11 44.7 0.0 7.2e-11 42.6 0.0 2.1 2 1 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 EXF75991.1 - 0.18 11.8 0.0 0.37 10.8 0.0 1.6 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain Inhibitor_I9 PF05922.16 EXF75992.1 - 1.5e-14 54.4 0.6 2.4e-14 53.7 0.6 1.3 1 1 0 1 1 1 1 Peptidase inhibitor I9 RIBIOP_C PF04950.12 EXF75993.1 - 4.6e-94 315.1 0.1 4.6e-94 315.1 0.1 2.1 2 0 0 2 2 1 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 EXF75993.1 - 4.3e-27 94.0 0.0 1.7e-26 92.1 0.0 2.1 1 0 0 1 1 1 1 AARP2CN (NUC121) domain AAA_22 PF13401.6 EXF75993.1 - 4.3e-05 23.8 0.1 0.00013 22.2 0.0 1.9 2 0 0 2 2 1 1 AAA domain AAA_16 PF13191.6 EXF75993.1 - 0.0001 22.7 0.0 0.00041 20.8 0.0 2.0 1 0 0 1 1 1 1 AAA ATPase domain ABC_tran PF00005.27 EXF75993.1 - 0.00031 21.3 0.4 0.0032 18.0 0.0 2.6 2 0 0 2 2 2 1 ABC transporter MMR_HSR1 PF01926.23 EXF75993.1 - 0.00051 20.1 0.0 0.0019 18.3 0.0 2.0 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA PF00004.29 EXF75993.1 - 0.00054 20.4 0.0 0.0015 19.0 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 EXF75993.1 - 0.00057 20.1 4.1 0.0015 18.7 0.0 2.7 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 EXF75993.1 - 0.00079 19.4 0.0 0.0019 18.2 0.0 1.7 1 1 0 1 1 1 1 NACHT domain AAA_19 PF13245.6 EXF75993.1 - 0.0022 18.3 0.2 0.01 16.2 0.0 2.1 2 0 0 2 2 2 1 AAA domain GTP_EFTU PF00009.27 EXF75993.1 - 0.0023 17.5 1.5 0.31 10.6 0.0 2.9 2 1 1 3 3 2 1 Elongation factor Tu GTP binding domain AAA_18 PF13238.6 EXF75993.1 - 0.0034 17.9 4.2 0.042 14.4 0.0 3.8 3 0 0 3 3 3 1 AAA domain RsgA_GTPase PF03193.16 EXF75993.1 - 0.0053 16.7 0.0 0.14 12.0 0.0 2.8 3 0 0 3 3 2 1 RsgA GTPase RNA_helicase PF00910.22 EXF75993.1 - 0.0074 16.7 0.0 0.022 15.1 0.0 1.9 1 0 0 1 1 1 1 RNA helicase PduV-EutP PF10662.9 EXF75993.1 - 0.011 15.4 0.0 0.054 13.2 0.0 2.0 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_30 PF13604.6 EXF75993.1 - 0.012 15.4 0.7 0.032 13.9 0.0 2.1 2 0 0 2 2 1 0 AAA domain AAA_14 PF13173.6 EXF75993.1 - 0.013 15.5 0.0 0.055 13.5 0.0 2.1 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 EXF75993.1 - 0.013 14.6 0.0 0.032 13.4 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain cobW PF02492.19 EXF75993.1 - 0.015 14.9 0.1 0.034 13.7 0.1 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_5 PF07728.14 EXF75993.1 - 0.019 15.0 1.6 0.2 11.7 0.0 2.6 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Ploopntkinase3 PF18751.1 EXF75993.1 - 0.02 14.8 0.0 0.044 13.7 0.0 1.5 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 AAA_28 PF13521.6 EXF75993.1 - 0.02 15.1 1.2 0.047 13.9 0.0 2.3 2 0 0 2 2 1 0 AAA domain NTPase_1 PF03266.15 EXF75993.1 - 0.029 14.3 0.2 0.063 13.2 0.2 1.6 1 0 0 1 1 1 0 NTPase Roc PF08477.13 EXF75993.1 - 0.036 14.3 0.0 0.11 12.7 0.0 1.9 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase MobB PF03205.14 EXF75993.1 - 0.037 13.9 0.9 0.54 10.2 0.1 2.8 3 0 0 3 3 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_7 PF12775.7 EXF75993.1 - 0.067 12.7 0.1 0.22 11.0 0.0 1.8 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_25 PF13481.6 EXF75993.1 - 0.1 12.2 0.0 0.24 10.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain WD40 PF00400.32 EXF75994.1 - 3.2e-11 43.6 4.6 0.00067 20.4 0.0 4.4 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EXF75994.1 - 4.4e-05 23.7 0.2 0.44 10.9 0.0 3.6 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EXF75994.1 - 4.8e-05 22.5 0.1 0.19 10.6 0.0 3.0 3 0 0 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Mo-co_dimer PF03404.16 EXF75994.1 - 0.011 15.7 0.1 0.02 14.9 0.1 1.3 1 0 0 1 1 1 0 Mo-co oxidoreductase dimerisation domain TFIIIC_delta PF12657.7 EXF75994.1 - 0.053 13.4 0.0 0.14 12.0 0.0 1.7 2 0 0 2 2 2 0 Transcription factor IIIC subunit delta N-term HemX PF04375.14 EXF75994.1 - 0.059 12.7 0.8 0.088 12.1 0.8 1.1 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase Fungal_trans_2 PF11951.8 EXF75995.1 - 3.3e-06 26.2 0.8 4.7e-06 25.7 0.8 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain MFS_1 PF07690.16 EXF75996.1 - 1.2e-42 146.1 58.6 1.9e-41 142.2 57.7 2.5 2 1 0 2 2 2 1 Major Facilitator Superfamily Fungal_trans PF04082.18 EXF75997.1 - 8.4e-16 57.8 0.0 1.3e-15 57.2 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF75997.1 - 1e-08 35.1 11.5 1.6e-08 34.5 11.5 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Glyco_hydro_15 PF00723.21 EXF75998.1 - 2.5e-84 283.6 0.1 3.1e-84 283.3 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 CBM_20 PF00686.19 EXF75998.1 - 4.4e-21 74.6 0.0 1.1e-20 73.3 0.0 1.7 1 0 0 1 1 1 1 Starch binding domain p450 PF00067.22 EXF75999.1 - 1.2e-47 162.8 0.0 1.5e-47 162.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Methyltransf_23 PF13489.6 EXF76000.1 - 0.0014 18.5 0.0 0.035 13.9 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EXF76001.1 - 1.6e-15 57.4 0.0 2.3e-15 56.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF76001.1 - 1.2e-10 41.9 0.0 2.9e-10 40.7 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF76001.1 - 2e-09 38.0 0.0 3.8e-09 37.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF76001.1 - 2.5e-09 37.8 0.0 1.3e-08 35.5 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF76001.1 - 1.4e-08 34.7 0.0 3.3e-08 33.5 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 EXF76001.1 - 0.00027 20.5 0.0 0.00089 18.8 0.0 1.8 2 0 0 2 2 2 1 Putative methyltransferase Ubie_methyltran PF01209.18 EXF76001.1 - 0.0019 17.6 0.0 0.054 12.8 0.0 2.7 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_2 PF00891.18 EXF76001.1 - 0.0059 15.9 0.0 0.0085 15.4 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain PrmA PF06325.13 EXF76001.1 - 0.0075 15.7 0.0 0.011 15.1 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 EXF76001.1 - 0.01 15.4 0.0 0.02 14.4 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase small domain Met_10 PF02475.16 EXF76001.1 - 0.12 12.1 0.0 0.16 11.7 0.0 1.2 1 0 0 1 1 1 0 Met-10+ like-protein CMAS PF02353.20 EXF76001.1 - 0.2 10.9 0.0 0.34 10.2 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase SUIM_assoc PF16619.5 EXF76002.1 - 0.0088 16.1 0.0 0.013 15.5 0.0 1.5 1 1 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 CDC45 PF02724.14 EXF76003.1 - 1.6e-253 842.7 0.0 4e-253 841.4 0.0 2.1 1 1 0 1 1 1 1 CDC45-like protein BUD22 PF09073.10 EXF76003.1 - 3.1 7.0 33.6 2.3 7.4 15.1 2.1 2 0 0 2 2 2 0 BUD22 Hemerythrin PF01814.23 EXF76004.1 - 3.2e-09 37.5 0.4 4.4e-09 37.0 0.4 1.2 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain EF-hand_7 PF13499.6 EXF76005.1 - 1.7e-25 89.3 8.9 1.4e-16 60.7 1.2 3.0 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 EXF76005.1 - 6.8e-25 84.8 4.9 3.8e-06 26.4 0.1 5.2 5 0 0 5 5 5 4 EF-hand domain EF-hand_1 PF00036.32 EXF76005.1 - 2.8e-24 82.8 13.8 3.2e-08 32.5 0.2 4.8 5 0 0 5 5 5 3 EF hand EF-hand_5 PF13202.6 EXF76005.1 - 2.5e-17 61.5 13.8 3.8e-05 23.0 0.1 4.6 5 0 0 5 5 5 4 EF hand EF-hand_8 PF13833.6 EXF76005.1 - 6.8e-15 54.7 12.2 3e-05 23.8 1.0 3.9 2 2 1 3 3 3 3 EF-hand domain pair EF-hand_4 PF12763.7 EXF76005.1 - 4.1e-09 36.3 8.1 0.0046 16.9 0.2 4.0 1 1 2 4 4 4 3 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 EXF76005.1 - 8.3e-05 22.8 0.6 0.0086 16.4 0.1 2.9 2 1 1 3 3 3 2 EF-hand domain SPARC_Ca_bdg PF10591.9 EXF76005.1 - 0.00097 19.4 3.4 0.96 9.8 0.4 3.1 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region DUF1679 PF07914.11 EXF76005.1 - 0.027 13.4 0.4 2.1 7.1 0.1 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF1679) EF-hand_10 PF14788.6 EXF76005.1 - 0.08 12.8 5.1 0.27 11.1 0.0 3.6 5 0 0 5 5 5 0 EF hand Staphylokinase PF02821.16 EXF76005.1 - 0.085 13.3 0.0 5.4 7.5 0.0 2.5 1 1 0 1 1 1 0 Staphylokinase/Streptokinase family EF-hand_14 PF17959.1 EXF76005.1 - 0.12 12.7 2.9 6.8 7.1 0.0 3.6 3 1 0 3 3 3 0 EF-hand domain AMP-binding PF00501.28 EXF76006.1 - 1e-87 294.5 0.1 1.5e-87 293.9 0.1 1.1 1 0 0 1 1 1 1 AMP-binding enzyme CdhD PF03599.16 EXF76006.1 - 0.043 12.5 0.0 0.072 11.8 0.0 1.2 1 0 0 1 1 1 0 CO dehydrogenase/acetyl-CoA synthase delta subunit 5-FTHF_cyc-lig PF01812.20 EXF76007.1 - 7.3e-28 97.7 0.0 1e-27 97.2 0.0 1.2 1 0 0 1 1 1 1 5-formyltetrahydrofolate cyclo-ligase family LSM PF01423.22 EXF76008.1 - 1.2e-15 56.9 0.1 1.5e-15 56.7 0.1 1.1 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 EXF76008.1 - 0.0023 17.6 0.1 0.0033 17.0 0.1 1.3 1 0 0 1 1 1 1 Hfq protein PhnA PF03831.14 EXF76008.1 - 0.094 12.6 0.1 2.3 8.2 0.0 2.2 2 0 0 2 2 2 0 PhnA domain Xpo1 PF08389.12 EXF76009.1 - 7.3e-29 100.7 1.9 2.3e-27 95.9 0.1 3.9 2 1 1 3 3 3 1 Exportin 1-like protein IBN_N PF03810.19 EXF76009.1 - 3.9e-07 29.9 0.0 3.2e-06 26.9 0.1 2.6 2 0 0 2 2 2 1 Importin-beta N-terminal domain Importin_rep_3 PF18806.1 EXF76009.1 - 0.00076 19.5 0.0 0.17 12.0 0.0 4.0 3 1 0 3 3 3 1 Importin 13 repeat HEAT_EZ PF13513.6 EXF76009.1 - 0.014 15.9 1.1 1.7 9.2 0.0 4.7 4 0 0 4 4 4 0 HEAT-like repeat Pox_F16 PF04708.12 EXF76009.1 - 0.049 13.1 0.0 0.11 12.0 0.0 1.5 1 0 0 1 1 1 0 Poxvirus F16 protein Adaptin_N PF01602.20 EXF76009.1 - 0.049 12.2 1.4 3.7 6.0 0.2 2.5 2 0 0 2 2 2 0 Adaptin N terminal region UME PF08064.13 EXF76009.1 - 0.4 10.6 7.0 1.3 8.9 0.1 4.8 6 0 0 6 6 6 0 UME (NUC010) domain ECM11 PF15463.6 EXF76010.1 - 8.4e-45 152.6 4.3 1.7e-44 151.6 4.3 1.6 1 0 0 1 1 1 1 Extracellular mutant protein 11 SRP54 PF00448.22 EXF76011.1 - 3.6e-05 23.5 0.0 5.6e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_18 PF13238.6 EXF76011.1 - 0.00012 22.6 0.0 0.00027 21.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EXF76011.1 - 0.00029 21.3 0.1 0.00073 20.0 0.1 1.5 1 1 0 1 1 1 1 AAA ATPase domain MeaB PF03308.16 EXF76011.1 - 0.00032 19.8 0.0 0.00053 19.1 0.0 1.2 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB NACHT PF05729.12 EXF76011.1 - 0.00099 19.1 0.0 0.0019 18.1 0.0 1.5 1 0 0 1 1 1 1 NACHT domain CBP_BcsQ PF06564.12 EXF76011.1 - 0.0021 17.6 0.3 0.016 14.7 0.0 2.2 2 0 0 2 2 2 1 Cellulose biosynthesis protein BcsQ ArsA_ATPase PF02374.15 EXF76011.1 - 0.0024 17.1 0.1 0.0045 16.2 0.1 1.3 1 0 0 1 1 1 1 Anion-transporting ATPase KAP_NTPase PF07693.14 EXF76011.1 - 0.003 16.9 0.0 0.0041 16.4 0.0 1.2 1 0 0 1 1 1 1 KAP family P-loop domain Zeta_toxin PF06414.12 EXF76011.1 - 0.0037 16.6 0.0 0.006 15.9 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin AAA_14 PF13173.6 EXF76011.1 - 0.0044 17.1 0.0 0.0079 16.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 EXF76011.1 - 0.006 17.0 0.0 0.016 15.7 0.0 1.6 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) CbiA PF01656.23 EXF76011.1 - 0.0098 16.0 0.0 0.011 15.8 0.0 1.3 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain TsaE PF02367.17 EXF76011.1 - 0.011 15.7 0.2 0.035 14.1 0.1 1.7 1 1 1 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE IstB_IS21 PF01695.17 EXF76011.1 - 0.013 15.2 0.0 0.03 14.0 0.0 1.5 1 1 0 1 1 1 0 IstB-like ATP binding protein AAA_31 PF13614.6 EXF76011.1 - 0.016 15.1 0.1 0.026 14.4 0.1 1.3 1 0 0 1 1 1 0 AAA domain APS_kinase PF01583.20 EXF76011.1 - 0.026 14.4 0.0 0.088 12.7 0.0 1.8 2 0 0 2 2 2 0 Adenylylsulphate kinase AAA_33 PF13671.6 EXF76011.1 - 0.03 14.5 0.0 0.058 13.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 EXF76011.1 - 0.035 13.8 0.0 0.084 12.6 0.0 1.6 2 0 0 2 2 2 0 AAA domain PRK PF00485.18 EXF76011.1 - 0.041 13.6 0.0 0.17 11.6 0.0 1.8 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family NB-ARC PF00931.22 EXF76011.1 - 0.064 12.4 0.9 0.15 11.2 0.2 1.9 2 1 0 2 2 2 0 NB-ARC domain Thymidylate_kin PF02223.17 EXF76011.1 - 0.064 12.9 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 Thymidylate kinase NTPase_1 PF03266.15 EXF76011.1 - 0.069 13.1 0.2 0.12 12.3 0.2 1.3 1 0 0 1 1 1 0 NTPase MobB PF03205.14 EXF76011.1 - 0.14 12.0 0.2 0.29 11.0 0.2 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B ABC_tran PF00005.27 EXF76011.1 - 0.21 12.1 0.1 0.49 10.9 0.1 1.7 1 1 0 1 1 1 0 ABC transporter adh_short PF00106.25 EXF76012.1 - 2.7e-85 284.8 10.4 2.9e-44 150.9 0.7 2.6 3 0 0 3 3 3 2 short chain dehydrogenase adh_short_C2 PF13561.6 EXF76012.1 - 2.7e-66 223.5 5.5 1.1e-34 120.1 0.4 2.4 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase MaoC_dehydratas PF01575.19 EXF76012.1 - 5.9e-33 113.1 0.0 1.2e-32 112.0 0.0 1.6 1 0 0 1 1 1 1 MaoC like domain KR PF08659.10 EXF76012.1 - 1.7e-30 106.3 2.6 3e-14 53.4 0.1 2.3 2 0 0 2 2 2 2 KR domain THF_DHG_CYH_C PF02882.19 EXF76012.1 - 4.2e-05 22.9 1.1 0.005 16.2 0.4 2.5 2 0 0 2 2 2 2 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Epimerase PF01370.21 EXF76012.1 - 0.0086 15.6 4.5 0.039 13.4 0.1 2.8 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family SoxE PF06525.11 EXF76012.1 - 0.038 13.5 0.1 4.6 6.7 0.0 2.8 2 0 0 2 2 2 0 Sulfocyanin (SoxE) domain MaoC_dehydrat_N PF13452.6 EXF76012.1 - 0.12 12.5 0.0 11 6.2 0.0 3.0 3 0 0 3 3 3 0 N-terminal half of MaoC dehydratase FAM25 PF15825.5 EXF76012.1 - 2.4 8.6 11.2 3.4 8.1 0.7 3.3 3 0 0 3 3 3 0 FAM25 family IBR PF01485.21 EXF76013.1 - 1.4e-05 25.2 5.4 1.4e-05 25.2 5.4 4.5 4 1 0 4 4 4 2 IBR domain, a half RING-finger domain adh_short PF00106.25 EXF76014.1 - 2.5e-53 180.5 0.0 3.2e-53 180.1 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF76014.1 - 2.2e-35 122.3 0.0 2.6e-35 122.1 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF76014.1 - 2.9e-14 53.4 0.0 4e-14 52.9 0.0 1.2 1 0 0 1 1 1 1 KR domain Sacchrp_dh_NADP PF03435.18 EXF76014.1 - 0.00091 19.5 0.0 0.0018 18.5 0.0 1.5 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Polysacc_synt_2 PF02719.15 EXF76014.1 - 0.0043 16.2 0.4 0.0095 15.1 0.2 1.6 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein RsgA_GTPase PF03193.16 EXF76014.1 - 0.053 13.4 1.0 2.9 7.8 0.4 2.2 1 1 1 2 2 2 0 RsgA GTPase MFS_1 PF07690.16 EXF76015.1 - 4.7e-41 140.9 45.8 1.1e-39 136.4 45.3 2.3 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF76015.1 - 2e-14 53.3 10.2 2e-14 53.3 10.2 2.5 2 1 0 2 2 2 1 Sugar (and other) transporter ThiF PF00899.21 EXF76016.1 - 1.6e-19 70.3 0.0 3.2e-19 69.2 0.0 1.6 1 1 0 1 1 1 1 ThiF family Fungal_trans PF04082.18 EXF76017.1 - 1.3e-23 83.4 0.0 2.3e-23 82.6 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF76017.1 - 3.5e-07 30.2 12.6 6.2e-07 29.4 12.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Haem_oxygenas_2 PF14518.6 EXF76017.1 - 0.057 13.2 0.2 0.11 12.3 0.2 1.4 1 0 0 1 1 1 0 Iron-containing redox enzyme zf-RING_5 PF14634.6 EXF76018.1 - 5e-07 29.6 11.5 8.8e-07 28.8 11.5 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 EXF76018.1 - 0.00025 20.8 7.5 0.00045 20.0 7.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EXF76018.1 - 0.00055 20.2 7.2 0.0011 19.3 7.2 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 EXF76018.1 - 0.0026 17.7 1.3 0.0026 17.7 1.3 1.9 1 1 1 2 2 2 1 RING-type zinc-finger ApoLp-III PF07464.11 EXF76018.1 - 0.0032 17.6 1.0 0.0048 17.0 1.0 1.2 1 0 0 1 1 1 1 Apolipophorin-III precursor (apoLp-III) zf-C3HC4_2 PF13923.6 EXF76018.1 - 0.0035 17.1 7.7 0.0088 15.9 7.7 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) DUF4201 PF13870.6 EXF76018.1 - 0.0042 16.8 0.9 0.0068 16.1 0.9 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4201) DUF948 PF06103.11 EXF76018.1 - 0.0083 16.4 0.4 0.014 15.7 0.4 1.3 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF948) zf-C3HC4_3 PF13920.6 EXF76018.1 - 0.027 14.3 10.2 0.051 13.5 10.2 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Syntaxin_2 PF14523.6 EXF76018.1 - 0.032 14.6 3.5 0.053 13.9 3.5 1.3 1 0 0 1 1 1 0 Syntaxin-like protein Prok-RING_4 PF14447.6 EXF76018.1 - 0.037 13.9 8.5 0.065 13.1 8.5 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 DUF4665 PF15679.5 EXF76018.1 - 0.042 14.5 0.3 0.077 13.6 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4665) Mito_carr PF00153.27 EXF76018.1 - 0.043 13.7 0.0 0.078 12.9 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial carrier protein DUF3584 PF12128.8 EXF76018.1 - 0.38 8.2 6.5 0.49 7.8 6.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Bap31_Bap29_C PF18035.1 EXF76018.1 - 0.7 10.0 3.7 1.4 9.0 3.7 1.5 1 0 0 1 1 1 0 Bap31/Bap29 cytoplasmic coiled-coil domain LPP PF04728.13 EXF76018.1 - 1.1 9.7 4.0 8.7 6.8 0.0 2.8 3 0 0 3 3 2 0 Lipoprotein leucine-zipper DUF573 PF04504.14 EXF76018.1 - 1.6 9.4 5.0 14 6.4 0.4 2.5 1 1 1 2 2 2 0 Protein of unknown function, DUF573 OmpH PF03938.14 EXF76018.1 - 2 8.8 7.6 1.3 9.4 6.1 1.4 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF4407 PF14362.6 EXF76018.1 - 5 6.4 6.4 7.1 5.9 6.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) GDA1_CD39 PF01150.17 EXF76019.1 - 6.5e-108 361.1 0.0 9.3e-108 360.6 0.0 1.1 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family DUF775 PF05603.12 EXF76020.1 - 7.4e-62 208.4 0.1 8.4e-62 208.2 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF775) DUF4743 PF15916.5 EXF76021.1 - 1.4e-10 41.2 0.0 2.3e-10 40.5 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4743) NUDIX PF00293.28 EXF76021.1 - 2.3e-10 40.6 0.1 4.4e-10 39.7 0.1 1.4 1 0 0 1 1 1 1 NUDIX domain RNA_pol_Rpb8 PF03870.15 EXF76022.1 - 3.6e-47 160.0 0.2 4.1e-47 159.9 0.2 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb8 RNA_pol_RpbG PF16992.5 EXF76022.1 - 8e-05 22.7 0.1 0.022 14.8 0.0 2.1 2 0 0 2 2 2 2 DNA-directed RNA polymerase, subunit G NB-ARC PF00931.22 EXF76022.1 - 0.091 11.9 0.0 0.12 11.6 0.0 1.1 1 0 0 1 1 1 0 NB-ARC domain PAXNEB PF05625.11 EXF76023.1 - 6.1e-101 338.2 0.0 7.3e-101 338.0 0.0 1.0 1 0 0 1 1 1 1 PAXNEB protein tRNA_int_endo PF01974.17 EXF76024.1 - 7.1e-14 51.6 0.0 1.3e-13 50.8 0.0 1.4 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain zf-C3HC4_3 PF13920.6 EXF76025.1 - 4.9e-09 35.9 12.5 7.9e-09 35.2 12.5 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EXF76025.1 - 0.04 13.8 13.0 0.067 13.1 13.0 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 RNase_PH PF01138.21 EXF76026.1 - 9.7e-28 97.3 0.1 1.9e-27 96.3 0.0 1.6 2 0 0 2 2 2 1 3' exoribonuclease family, domain 1 Anp1 PF03452.14 EXF76027.1 - 2.4e-113 377.9 0.6 7.9e-113 376.2 0.0 1.8 2 0 0 2 2 2 1 Anp1 DUF998 PF06197.13 EXF76027.1 - 0.12 11.9 2.1 0.2 11.3 2.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF998) Smg8_Smg9 PF10220.9 EXF76027.1 - 0.57 8.4 9.7 0.78 8.0 9.7 1.1 1 0 0 1 1 1 0 Smg8_Smg9 Sec7 PF01369.20 EXF76028.1 - 8.8e-66 221.1 0.0 1.6e-65 220.2 0.0 1.5 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.7 EXF76028.1 - 8.5e-16 58.3 0.0 9.1e-15 54.9 0.0 2.7 2 0 0 2 2 2 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DCB PF16213.5 EXF76028.1 - 0.019 14.6 0.1 0.13 11.9 0.0 2.4 2 0 0 2 2 2 0 Dimerisation and cyclophilin-binding domain of Mon2 RRM_1 PF00076.22 EXF76029.1 - 1.3e-25 89.0 0.7 1.8e-12 46.9 0.3 2.5 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EXF76029.1 - 8.6e-06 25.4 0.0 0.00027 20.5 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF1866 PF08952.11 EXF76029.1 - 0.0041 17.0 0.0 0.13 12.1 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF1866) RRM_occluded PF16842.5 EXF76029.1 - 0.025 14.4 0.0 5 7.1 0.0 2.2 2 0 0 2 2 2 0 Occluded RNA-recognition motif ATP-synt_D PF01813.17 EXF76030.1 - 7.8e-71 238.0 0.9 9.5e-71 237.7 0.9 1.1 1 0 0 1 1 1 1 ATP synthase subunit D CobA_CobO_BtuR PF02572.15 EXF76030.1 - 0.31 11.3 2.7 1 9.6 0.1 2.3 2 1 1 3 3 3 0 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP DUF5446 PF17522.2 EXF76030.1 - 0.68 10.1 2.4 0.8 9.9 0.7 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5446) TPR_14 PF13428.6 EXF76031.1 - 7.3e-13 48.2 22.2 3.2 8.8 0.0 11.6 10 2 2 12 12 12 3 Tetratricopeptide repeat Suf PF05843.14 EXF76031.1 - 4.6e-11 43.2 8.4 0.031 14.3 0.0 6.0 4 1 1 6 6 6 3 Suppressor of forked protein (Suf) TPR_15 PF13429.6 EXF76031.1 - 1.6e-07 30.8 3.6 9.7e-05 21.7 0.5 4.2 4 1 1 5 5 5 2 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 EXF76031.1 - 2.8e-06 27.3 9.3 0.23 11.4 0.1 6.7 7 0 0 7 7 7 3 Mad3/BUB1 homology region 1 TPR_8 PF13181.6 EXF76031.1 - 7.5e-06 25.8 5.3 0.14 12.4 0.0 6.2 7 0 0 7 7 5 1 Tetratricopeptide repeat TPR_12 PF13424.6 EXF76031.1 - 3e-05 24.2 3.8 3.8 7.9 0.0 6.7 7 0 0 7 7 7 1 Tetratricopeptide repeat RPN7 PF10602.9 EXF76031.1 - 0.0016 18.1 2.9 0.01 15.6 0.4 3.4 3 2 0 3 3 3 1 26S proteasome subunit RPN7 TPR_2 PF07719.17 EXF76031.1 - 0.0032 17.5 15.1 1.9 8.8 0.0 7.2 9 0 0 9 9 9 1 Tetratricopeptide repeat NRDE-2 PF08424.10 EXF76031.1 - 0.0078 15.4 14.7 0.031 13.4 0.3 6.3 3 2 4 7 7 7 1 NRDE-2, necessary for RNA interference TPR_4 PF07721.14 EXF76031.1 - 0.073 13.7 0.4 3.1 8.7 0.1 3.3 2 0 0 2 2 2 0 Tetratricopeptide repeat MIT PF04212.18 EXF76031.1 - 0.18 11.9 0.8 1.2 9.2 0.1 2.8 3 0 0 3 3 2 0 MIT (microtubule interacting and transport) domain TPR_10 PF13374.6 EXF76031.1 - 0.23 11.4 11.6 23 5.0 0.0 6.4 6 0 0 6 6 6 0 Tetratricopeptide repeat LEM PF03020.15 EXF76031.1 - 0.76 9.4 2.1 25 4.5 0.0 3.0 3 0 0 3 3 3 0 LEM domain Egh16-like PF11327.8 EXF76033.1 - 1.7e-52 178.5 9.5 2.1e-52 178.2 9.5 1.1 1 0 0 1 1 1 1 Egh16-like virulence factor PolyA_pol PF01743.20 EXF76034.1 - 7.1e-27 94.3 0.1 1.5e-26 93.3 0.1 1.6 1 0 0 1 1 1 1 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.7 EXF76034.1 - 1.7e-06 27.7 0.0 3.9e-06 26.5 0.0 1.6 1 0 0 1 1 1 1 Probable RNA and SrmB- binding site of polymerase A tRNA_NucTran2_2 PF13735.6 EXF76034.1 - 0.012 15.6 0.0 0.023 14.7 0.0 1.4 1 0 0 1 1 1 0 tRNA nucleotidyltransferase domain 2 putative Tti2 PF10521.9 EXF76035.1 - 1.7e-19 70.4 0.1 2.8e-19 69.8 0.1 1.3 1 0 0 1 1 1 1 Tti2 family DUF1844 PF08899.11 EXF76035.1 - 0.021 15.1 0.0 0.051 13.9 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1844) Syja_N PF02383.18 EXF76036.1 - 8.2e-75 252.1 0.0 1.7e-74 251.0 0.0 1.6 1 0 0 1 1 1 1 SacI homology domain HD_6 PF18019.1 EXF76036.1 - 0.14 12.2 0.6 0.46 10.6 0.1 1.9 2 0 0 2 2 2 0 HD domain Seryl_tRNA_N PF02403.22 EXF76037.1 - 0.028 14.7 0.8 0.028 14.7 0.8 2.7 3 1 0 3 3 3 0 Seryl-tRNA synthetase N-terminal domain Filament PF00038.21 EXF76037.1 - 0.081 12.5 4.4 0.16 11.5 0.2 2.5 2 1 0 2 2 2 0 Intermediate filament protein DUF848 PF05852.11 EXF76037.1 - 0.69 10.0 3.7 1.1 9.4 0.4 2.4 2 0 0 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) KELK PF15796.5 EXF76037.1 - 0.72 10.3 6.0 0.35 11.3 0.6 2.5 2 1 1 3 3 3 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase Spc7 PF08317.11 EXF76037.1 - 1.3 7.8 13.4 0.017 14.0 1.5 2.6 3 1 0 3 3 3 0 Spc7 kinetochore protein CENP-F_leu_zip PF10473.9 EXF76037.1 - 1.4 8.9 10.6 0.9 9.6 1.6 3.6 2 2 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GAS PF13851.6 EXF76037.1 - 3 7.2 6.2 4.8 6.5 1.2 2.5 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding SOAR PF16533.5 EXF76037.1 - 3.6 7.6 6.5 0.46 10.5 0.5 2.5 3 0 0 3 3 3 0 STIM1 Orai1-activating region FlgN PF05130.12 EXF76037.1 - 7.6 7.0 12.9 6.8 7.2 1.6 3.1 3 0 0 3 3 3 0 FlgN protein WD40 PF00400.32 EXF76038.1 - 3e-11 43.7 5.7 0.00048 20.9 0.0 5.1 4 0 0 4 4 4 3 WD domain, G-beta repeat ADH_zinc_N PF00107.26 EXF76039.1 - 1.4e-29 102.7 0.1 2.4e-29 101.9 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EXF76039.1 - 4.2e-13 50.5 0.0 6.5e-13 49.9 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EXF76039.1 - 6.7e-07 29.2 0.0 7.9e-06 25.7 0.0 2.2 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain Spt5-NGN PF03439.13 EXF76040.1 - 5.6e-25 87.1 0.0 9.2e-25 86.4 0.0 1.4 1 0 0 1 1 1 1 Early transcription elongation factor of RNA pol II, NGN section Spt5_N PF11942.8 EXF76040.1 - 1.2e-21 77.5 10.0 1.2e-21 77.5 10.0 3.4 2 1 1 3 3 3 1 Spt5 transcription elongation factor, acidic N-terminal CTD PF12815.7 EXF76040.1 - 2.4e-21 76.1 35.6 4.4e-19 68.8 18.6 4.3 1 1 2 3 3 3 2 Spt5 C-terminal nonapeptide repeat binding Spt4 KOW PF00467.29 EXF76040.1 - 2.5e-05 24.1 20.5 0.0002 21.2 0.4 5.3 6 0 0 6 6 6 2 KOW motif Cornifin PF02389.15 EXF76040.1 - 0.0025 18.0 1.4 0.0066 16.7 1.4 1.6 1 0 0 1 1 1 1 Cornifin (SPRR) family Oxidored_molyb PF00174.19 EXF76041.1 - 1.7e-57 193.8 0.0 2.4e-57 193.3 0.0 1.2 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain Mo-co_dimer PF03404.16 EXF76041.1 - 3.5e-27 95.1 0.1 6.6e-27 94.2 0.1 1.5 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain Cyt-b5 PF00173.28 EXF76041.1 - 1.7e-11 44.1 0.0 3.1e-11 43.2 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain mRNA_triPase PF02940.15 EXF76042.1 - 5.8e-56 189.7 0.0 8.3e-56 189.2 0.0 1.2 1 0 0 1 1 1 1 mRNA capping enzyme, beta chain RPN2_C PF18004.1 EXF76043.1 - 2.6e-58 196.5 5.7 2.6e-58 196.5 5.7 1.9 2 0 0 2 2 2 1 26S proteasome regulatory subunit RPN2 C-terminal domain PC_rep PF01851.22 EXF76043.1 - 6e-40 133.7 23.7 1.2e-08 34.9 0.0 9.0 9 0 0 9 9 9 7 Proteasome/cyclosome repeat HEAT_2 PF13646.6 EXF76043.1 - 7.8e-21 74.3 0.0 3e-14 53.2 0.0 5.6 3 1 2 5 5 5 2 HEAT repeats HEAT PF02985.22 EXF76043.1 - 1.6e-06 27.8 0.9 3.2 8.3 0.0 6.3 6 0 0 6 6 6 2 HEAT repeat HEAT_EZ PF13513.6 EXF76043.1 - 0.00015 22.2 0.1 0.021 15.3 0.0 4.4 3 1 1 4 4 4 2 HEAT-like repeat Cnd1 PF12717.7 EXF76043.1 - 0.0049 16.9 0.2 2.8 8.0 0.0 3.2 2 1 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 TPR_19 PF14559.6 EXF76043.1 - 0.071 13.6 0.7 24 5.5 1.1 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TAL_FSA PF00923.19 EXF76044.1 - 1.6e-45 155.7 0.0 1.9e-45 155.5 0.0 1.1 1 0 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase WbqC PF08889.11 EXF76044.1 - 0.047 13.6 0.0 0.084 12.8 0.0 1.4 1 0 0 1 1 1 0 WbqC-like protein family AA_permease_2 PF13520.6 EXF76045.1 - 2.7e-63 214.3 28.1 6.1e-63 213.1 26.5 2.3 1 1 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EXF76045.1 - 2.5e-11 42.8 19.9 2.5e-11 42.8 19.9 3.4 3 1 0 3 3 3 1 Amino acid permease Xan_ur_permease PF00860.20 EXF76047.1 - 1.4e-62 211.6 34.1 1.5e-61 208.3 34.1 2.0 1 1 0 1 1 1 1 Permease family Transp_cyt_pur PF02133.15 EXF76048.1 - 1.5e-92 310.7 36.0 1.8e-92 310.5 36.0 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Shikimate_dh_N PF08501.11 EXF76049.1 - 2.3e-22 79.0 0.0 6.7e-22 77.5 0.0 1.9 1 0 0 1 1 1 1 Shikimate dehydrogenase substrate binding domain DHquinase_I PF01487.15 EXF76049.1 - 2.1e-21 77.3 0.0 3.5e-21 76.5 0.0 1.3 1 0 0 1 1 1 1 Type I 3-dehydroquinase SKI PF01202.22 EXF76049.1 - 4.4e-10 39.9 0.4 1.1e-09 38.6 0.1 1.7 2 0 0 2 2 2 1 Shikimate kinase SDH_C PF18317.1 EXF76049.1 - 7.9e-09 35.1 0.2 1.6e-08 34.1 0.2 1.6 1 0 0 1 1 1 1 Shikimate 5'-dehydrogenase C-terminal domain Shikimate_DH PF01488.20 EXF76049.1 - 1.5e-06 28.3 0.1 3.2e-06 27.2 0.1 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase AAA_25 PF13481.6 EXF76049.1 - 0.00056 19.5 0.0 0.06 12.9 0.0 2.3 2 0 0 2 2 2 1 AAA domain F420_oxidored PF03807.17 EXF76049.1 - 0.058 14.0 0.0 0.21 12.2 0.0 1.9 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Fungal_trans PF04082.18 EXF76050.1 - 6.2e-13 48.4 0.0 8.4e-13 48.0 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF76050.1 - 0.00018 21.6 1.2 0.00039 20.5 1.2 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF1688 PF07958.11 EXF76050.1 - 0.018 13.8 0.0 0.027 13.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1688) Vpu PF00558.19 EXF76050.1 - 0.1 12.4 0.1 0.21 11.4 0.1 1.4 1 0 0 1 1 1 0 Vpu protein Sugar_tr PF00083.24 EXF76051.1 - 8e-137 456.8 26.0 9.2e-137 456.6 26.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF76051.1 - 9.1e-23 80.7 36.8 9.1e-23 80.7 36.8 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily Shikimate_dh_N PF08501.11 EXF76052.1 - 9.3e-22 77.1 0.0 1.8e-21 76.2 0.0 1.5 1 0 0 1 1 1 1 Shikimate dehydrogenase substrate binding domain SDH_C PF18317.1 EXF76052.1 - 3.2e-06 26.8 0.0 6e-06 25.9 0.0 1.5 1 0 0 1 1 1 1 Shikimate 5'-dehydrogenase C-terminal domain Shikimate_DH PF01488.20 EXF76052.1 - 0.014 15.4 0.0 0.025 14.6 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase AP_endonuc_2 PF01261.24 EXF76053.1 - 1.6e-33 115.9 0.2 2.5e-33 115.3 0.2 1.2 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel Inositol_P PF00459.25 EXF76054.1 - 3.9e-79 266.0 0.0 4.4e-79 265.8 0.0 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family Fe-ADH PF00465.19 EXF76055.1 - 9.4e-66 222.1 2.0 3.3e-65 220.3 2.0 1.7 1 1 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 EXF76055.1 - 1.4e-11 44.6 0.0 3.2e-11 43.4 0.0 1.5 1 1 0 1 1 1 1 Iron-containing alcohol dehydrogenase ANAPC4_WD40 PF12894.7 EXF76056.1 - 3.9e-07 30.3 0.0 0.00075 19.7 0.0 3.3 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EXF76056.1 - 0.013 16.3 9.8 1.8 9.5 0.0 4.9 4 1 1 5 5 5 0 WD domain, G-beta repeat PQQ_3 PF13570.6 EXF76056.1 - 0.2 12.2 1.8 27 5.4 0.1 3.8 4 0 0 4 4 4 0 PQQ-like domain CDC45 PF02724.14 EXF76056.1 - 0.59 8.4 6.2 0.84 7.9 6.2 1.1 1 0 0 1 1 1 0 CDC45-like protein BUD22 PF09073.10 EXF76056.1 - 0.6 9.4 7.8 0.9 8.8 7.8 1.2 1 0 0 1 1 1 0 BUD22 Cwf_Cwc_15 PF04889.12 EXF76056.1 - 1.9 8.1 10.0 3.1 7.5 10.0 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Pes-10 PF07149.11 EXF76056.1 - 2.2 7.3 3.1 3.1 6.7 3.1 1.1 1 0 0 1 1 1 0 Pes-10 Glyco_hydro_18 PF00704.28 EXF76057.1 - 2.7e-69 234.3 0.0 3.1e-69 234.1 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 GHL15 PF14885.6 EXF76057.1 - 9.6e-05 22.5 0.0 0.00017 21.7 0.0 1.4 1 0 0 1 1 1 1 Hypothetical glycosyl hydrolase family 15 MARVEL PF01284.23 EXF76058.1 - 4.1e-16 59.3 20.5 5.7e-16 58.8 20.5 1.2 1 0 0 1 1 1 1 Membrane-associating domain GDPD PF03009.17 EXF76059.1 - 1.2e-11 44.9 0.0 1.5e-11 44.6 0.0 1.2 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family DUF2782 PF11191.8 EXF76059.1 - 0.13 12.5 0.9 8 6.7 0.0 3.3 4 0 0 4 4 4 0 Protein of unknown function (DUF2782) Diphthamide_syn PF01866.17 EXF76060.1 - 2.3e-87 293.3 0.0 2.8e-87 293.0 0.0 1.1 1 0 0 1 1 1 1 Putative diphthamide synthesis protein MARVEL PF01284.23 EXF76061.1 - 0.0014 18.7 15.7 0.002 18.2 15.7 1.2 1 0 0 1 1 1 1 Membrane-associating domain DUF4293 PF14126.6 EXF76061.1 - 0.0052 17.1 4.9 0.011 15.9 3.7 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4293) TspO_MBR PF03073.15 EXF76061.1 - 0.029 14.4 13.0 0.58 10.2 0.0 2.1 2 0 0 2 2 2 0 TspO/MBR family 7TMR-DISM_7TM PF07695.11 EXF76061.1 - 0.048 13.5 17.2 0.84 9.5 12.3 2.1 2 0 0 2 2 2 0 7TM diverse intracellular signalling Myc_target_1 PF15179.6 EXF76061.1 - 3.9 7.3 9.0 1.3 8.9 2.5 2.1 2 0 0 2 2 2 0 Myc target protein 1 Sin3a_C PF16879.5 EXF76062.1 - 2.2e-75 254.0 0.9 2.2e-75 254.0 0.9 2.7 4 0 0 4 4 4 1 C-terminal domain of Sin3a protein PAH PF02671.21 EXF76062.1 - 8.8e-45 150.6 8.3 7.2e-18 64.5 2.8 4.4 3 1 1 4 4 4 3 Paired amphipathic helix repeat Sin3_corepress PF08295.12 EXF76062.1 - 1.2e-38 131.1 0.0 2.7e-38 130.0 0.0 1.7 1 0 0 1 1 1 1 Sin3 family co-repressor DUF2764 PF10962.8 EXF76062.1 - 0.076 12.5 0.2 0.35 10.3 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2764) Fasciclin PF02469.22 EXF76063.1 - 0.019 15.2 0.0 0.03 14.5 0.0 1.3 1 0 0 1 1 1 0 Fasciclin domain FAD_binding_2 PF00890.24 EXF76064.1 - 8.7e-83 278.7 0.7 1.1e-82 278.4 0.7 1.1 1 0 0 1 1 1 1 FAD binding domain Cyt-b5 PF00173.28 EXF76064.1 - 2e-21 75.9 0.0 1.5e-20 73.1 0.0 2.5 3 0 0 3 3 3 1 Cytochrome b5-like Heme/Steroid binding domain DAO PF01266.24 EXF76064.1 - 1.1e-13 51.5 0.2 2e-13 50.7 0.2 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_oxidored PF12831.7 EXF76064.1 - 5.7e-10 39.1 0.9 3.5e-09 36.5 0.9 2.0 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EXF76064.1 - 1.4e-07 31.6 2.7 6.3e-07 29.5 0.8 2.8 2 1 1 3 3 3 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EXF76064.1 - 9.3e-07 28.4 0.2 1.4e-05 24.5 0.1 2.4 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EXF76064.1 - 2.6e-05 23.7 0.0 0.18 11.1 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EXF76064.1 - 5.9e-05 22.5 0.3 0.00013 21.4 0.4 1.4 1 1 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 EXF76064.1 - 0.00012 20.9 4.1 0.011 14.5 0.5 3.3 3 1 0 3 3 3 1 HI0933-like protein Thi4 PF01946.17 EXF76064.1 - 0.00091 18.5 1.9 0.062 12.5 0.9 2.4 2 0 0 2 2 2 1 Thi4 family Amino_oxidase PF01593.24 EXF76064.1 - 0.002 17.5 0.7 0.26 10.5 0.2 2.9 3 0 0 3 3 3 1 Flavin containing amine oxidoreductase GIDA PF01134.22 EXF76064.1 - 0.0087 15.2 3.7 0.17 11.0 1.5 2.3 2 0 0 2 2 2 1 Glucose inhibited division protein A AlaDh_PNT_C PF01262.21 EXF76064.1 - 0.042 13.1 0.8 0.077 12.3 0.8 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox PF00070.27 EXF76064.1 - 0.081 13.5 2.3 2.1 9.0 0.5 2.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Methyltransf_23 PF13489.6 EXF76065.1 - 2.2e-17 63.4 0.0 3.7e-17 62.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF76065.1 - 6e-08 33.3 0.0 1.2e-07 32.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF76065.1 - 2.6e-07 30.6 0.0 1.2e-06 28.4 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF76065.1 - 4.6e-05 24.1 0.0 0.00016 22.3 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF76065.1 - 0.00011 22.7 0.0 0.00021 21.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 EXF76065.1 - 0.009 15.5 0.0 0.02 14.3 0.0 1.6 1 0 0 1 1 1 1 Putative methyltransferase MTS PF05175.14 EXF76065.1 - 0.014 15.0 0.0 0.025 14.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_16 PF10294.9 EXF76065.1 - 0.089 12.5 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase FtsJ PF01728.19 EXF76065.1 - 0.089 12.9 0.0 0.14 12.2 0.0 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase CMAS PF02353.20 EXF76065.1 - 0.09 12.0 0.0 0.15 11.3 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase DUF1708 PF08101.11 EXF76067.1 - 4.4e-180 599.4 0.0 7.7e-180 598.7 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1708) Flavokinase PF01687.17 EXF76068.1 - 0.028 14.7 0.0 0.032 14.5 0.0 1.1 1 0 0 1 1 1 0 Riboflavin kinase Epimerase PF01370.21 EXF76069.1 - 3.7e-08 33.1 0.0 5.5e-08 32.6 0.0 1.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EXF76069.1 - 5.7e-08 32.9 0.2 7.2e-08 32.5 0.2 1.3 1 0 0 1 1 1 1 NAD(P)H-binding HIM1 PF08732.10 EXF76069.1 - 7.8e-07 28.8 0.0 1.1e-06 28.3 0.0 1.1 1 0 0 1 1 1 1 HIM1 NmrA PF05368.13 EXF76069.1 - 0.00039 20.0 0.6 0.0015 18.2 0.6 1.8 1 1 0 1 1 1 1 NmrA-like family Semialdhyde_dh PF01118.24 EXF76069.1 - 0.04 14.4 0.0 0.095 13.1 0.0 1.6 1 1 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain zf-RING_2 PF13639.6 EXF76070.1 - 1.2e-10 41.5 4.9 1.9e-10 40.9 4.9 1.3 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 EXF76070.1 - 3.5e-07 30.4 5.5 2.2e-06 27.9 5.5 2.1 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 EXF76070.1 - 8.9e-07 28.9 0.9 1.5e-06 28.2 0.9 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 EXF76070.1 - 4.4e-05 23.4 2.6 4.8e-05 23.3 1.3 1.8 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EXF76070.1 - 4.5e-05 23.2 6.0 0.00017 21.4 6.1 1.9 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EXF76070.1 - 0.00014 21.6 2.8 0.0003 20.6 2.7 1.6 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EXF76070.1 - 0.0011 18.8 3.2 0.0018 18.1 3.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EXF76070.1 - 0.0017 18.2 4.7 0.2 11.5 1.5 2.3 2 0 0 2 2 2 2 Prokaryotic RING finger family 4 FANCL_C PF11793.8 EXF76070.1 - 0.006 16.7 2.6 0.26 11.5 2.8 2.5 2 1 0 2 2 1 1 FANCL C-terminal domain zf-RING_4 PF14570.6 EXF76070.1 - 0.008 15.9 3.6 0.02 14.6 3.6 1.7 1 1 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-RING_11 PF17123.5 EXF76070.1 - 0.0082 15.9 1.4 0.018 14.7 1.4 1.6 1 0 0 1 1 1 1 RING-like zinc finger UBZ_FAAP20 PF15750.5 EXF76070.1 - 0.011 15.7 1.5 1.7 8.6 0.2 2.6 2 0 0 2 2 2 0 Ubiquitin-binding zinc-finger Rad50_zn_hook PF04423.14 EXF76070.1 - 0.011 15.5 3.6 0.82 9.6 0.3 2.5 2 0 0 2 2 2 0 Rad50 zinc hook motif zf-Di19 PF05605.12 EXF76070.1 - 0.061 13.6 2.3 6.3 7.2 0.3 2.6 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Prok-RING_1 PF14446.6 EXF76070.1 - 0.061 13.2 4.9 3.4 7.7 0.6 2.3 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 zf-RING_5 PF14634.6 EXF76070.1 - 0.065 13.2 1.5 0.14 12.2 1.6 1.5 1 1 0 1 1 1 0 zinc-RING finger domain Zn-C2H2_12 PF18112.1 EXF76070.1 - 0.29 11.6 3.4 5.3 7.6 0.1 2.5 2 0 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain Tmpp129 PF10272.9 EXF76070.1 - 0.31 10.3 1.8 0.41 9.9 0.4 1.7 2 0 0 2 2 2 0 Putative transmembrane protein precursor zf-UDP PF14569.6 EXF76070.1 - 0.54 10.4 4.8 2.8 8.1 4.8 2.0 1 1 0 1 1 1 0 Zinc-binding RING-finger Pheromone PF08015.11 EXF76070.1 - 1.4 10.0 9.3 2.6 9.2 1.6 2.4 2 0 0 2 2 2 0 Fungal mating-type pheromone zf-C3HC4_5 PF17121.5 EXF76070.1 - 2.7 7.9 5.3 16 5.5 5.4 2.2 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Pkinase PF00069.25 EXF76072.1 - 4.7e-50 170.4 0.0 6.2e-50 170.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF76072.1 - 5.4e-27 94.7 0.0 7.6e-27 94.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EXF76072.1 - 0.00097 18.5 0.0 0.0016 17.8 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EXF76072.1 - 0.0033 16.8 0.0 0.0058 16.0 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EXF76072.1 - 0.017 13.9 0.0 0.025 13.4 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase APH PF01636.23 EXF76072.1 - 0.046 13.6 0.2 0.046 13.6 0.2 1.9 2 0 0 2 2 2 0 Phosphotransferase enzyme family PAP1 PF08601.10 EXF76073.1 - 8.3e-86 289.0 54.4 9.7e-62 209.8 4.5 4.1 1 1 3 4 4 4 3 Transcription factor PAP1 bZIP_1 PF00170.21 EXF76073.1 - 7.6e-11 41.9 11.9 1.7e-10 40.8 11.9 1.6 1 0 0 1 1 1 1 bZIP transcription factor ERM PF00769.19 EXF76073.1 - 0.00035 20.5 2.9 0.00064 19.6 2.9 1.5 1 0 0 1 1 1 1 Ezrin/radixin/moesin family Spc29 PF17082.5 EXF76073.1 - 0.0013 18.6 2.7 0.0013 18.6 2.7 1.8 2 0 0 2 2 2 1 Spindle Pole Component 29 SlyX PF04102.12 EXF76073.1 - 0.0051 17.4 1.6 0.0053 17.3 0.2 1.8 2 0 0 2 2 1 1 SlyX bZIP_2 PF07716.15 EXF76073.1 - 0.0051 16.9 12.1 0.038 14.1 12.1 2.1 1 1 0 1 1 1 1 Basic region leucine zipper DUF812 PF05667.11 EXF76073.1 - 0.0091 14.9 7.9 0.014 14.3 7.9 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF812) APG6_N PF17675.1 EXF76073.1 - 0.0092 16.5 4.4 0.02 15.4 4.4 1.5 1 0 0 1 1 1 1 Apg6 coiled-coil region SHE3 PF17078.5 EXF76073.1 - 0.01 15.5 6.1 0.01 15.5 6.1 1.9 2 0 0 2 2 2 0 SWI5-dependent HO expression protein 3 Prominin PF05478.11 EXF76073.1 - 0.02 12.9 0.7 0.03 12.3 0.7 1.1 1 0 0 1 1 1 0 Prominin IFT57 PF10498.9 EXF76073.1 - 0.032 13.2 6.0 0.06 12.3 6.0 1.4 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 NPV_P10 PF05531.12 EXF76073.1 - 0.048 14.1 0.8 0.048 14.1 0.8 1.9 2 0 0 2 2 1 0 Nucleopolyhedrovirus P10 protein Cluap1 PF10234.9 EXF76073.1 - 0.14 11.6 6.3 0.3 10.5 6.3 1.5 1 0 0 1 1 1 0 Clusterin-associated protein-1 Herpes_UL6 PF01763.16 EXF76073.1 - 0.16 10.4 1.3 0.24 9.9 1.3 1.2 1 0 0 1 1 1 0 Herpesvirus UL6 like DOG1 PF14144.6 EXF76073.1 - 0.18 12.1 0.1 0.43 10.8 0.1 1.6 1 0 0 1 1 1 0 Seed dormancy control UPF0242 PF06785.11 EXF76073.1 - 0.18 11.9 5.8 0.36 10.9 5.8 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF1664 PF07889.12 EXF76073.1 - 0.19 11.8 0.6 0.5 10.4 0.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) DUF5082 PF16888.5 EXF76073.1 - 0.25 11.6 8.0 0.37 11.1 5.9 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) JIP_LZII PF16471.5 EXF76073.1 - 0.3 11.3 4.5 3.9 7.7 2.8 2.4 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II WXG100 PF06013.12 EXF76073.1 - 0.33 11.2 3.0 1.4 9.2 0.2 2.5 2 0 0 2 2 2 0 Proteins of 100 residues with WXG V_ATPase_I PF01496.19 EXF76073.1 - 0.41 8.5 2.1 0.7 7.7 2.1 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TolA_bind_tri PF16331.5 EXF76073.1 - 0.43 10.7 2.8 0.44 10.7 0.2 2.1 2 0 0 2 2 2 0 TolA binding protein trimerisation FlaC_arch PF05377.11 EXF76073.1 - 0.58 10.6 2.6 1.2 9.5 2.6 1.5 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) Jnk-SapK_ap_N PF09744.9 EXF76073.1 - 0.67 10.2 7.2 1.4 9.2 7.2 1.4 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 TMCO5 PF14992.6 EXF76073.1 - 0.68 9.5 5.7 1.3 8.5 5.7 1.4 1 0 0 1 1 1 0 TMCO5 family DUF4407 PF14362.6 EXF76073.1 - 0.97 8.7 4.2 1.5 8.1 4.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF724 PF05266.14 EXF76073.1 - 1 9.1 7.1 1.7 8.4 7.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF724) bZIP_Maf PF03131.17 EXF76073.1 - 1.3 9.6 11.5 0.38 11.3 8.4 1.7 2 0 0 2 2 1 0 bZIP Maf transcription factor Snapin_Pallidin PF14712.6 EXF76073.1 - 1.6 9.2 6.7 0.94 9.9 1.1 2.4 2 0 0 2 2 2 0 Snapin/Pallidin DivIC PF04977.15 EXF76073.1 - 1.7 8.5 4.5 4.3 7.2 4.5 1.7 1 0 0 1 1 1 0 Septum formation initiator TMPIT PF07851.13 EXF76073.1 - 4 6.6 6.4 1.8 7.8 3.2 1.8 2 0 0 2 2 2 0 TMPIT-like protein Prefoldin_2 PF01920.20 EXF76073.1 - 4.9 7.1 10.4 0.72 9.8 6.1 1.8 2 0 0 2 2 1 0 Prefoldin subunit Atg14 PF10186.9 EXF76073.1 - 5.4 6.0 11.2 0.77 8.8 7.3 1.4 2 0 0 2 2 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 LegC3_N PF18654.1 EXF76073.1 - 7.2 5.7 12.0 1.8 7.7 8.5 1.7 2 0 0 2 2 2 0 LegC3 N-terminal coiled-coil domain XhlA PF10779.9 EXF76073.1 - 7.9 6.8 5.7 16 5.7 5.7 1.5 1 0 0 1 1 1 0 Haemolysin XhlA BSD PF03909.17 EXF76074.1 - 1e-19 70.3 1.2 1.4e-19 69.8 0.2 1.8 2 0 0 2 2 2 1 BSD domain Sigma70_r2 PF04542.14 EXF76074.1 - 0.0071 16.1 0.4 0.016 14.9 0.0 1.8 2 0 0 2 2 2 1 Sigma-70 region 2 HET PF06985.11 EXF76074.1 - 0.38 11.1 3.0 2.9 8.2 0.2 2.8 3 0 0 3 3 3 0 Heterokaryon incompatibility protein (HET) DUF4407 PF14362.6 EXF76074.1 - 8.4 5.7 7.9 2 7.7 4.5 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) WGG PF10273.9 EXF76075.1 - 4.1e-27 94.7 0.1 8.4e-27 93.7 0.1 1.5 1 0 0 1 1 1 1 Pre-rRNA-processing protein TSR2 RRP7 PF12923.7 EXF76075.1 - 0.0054 16.9 0.5 0.015 15.5 0.1 1.9 2 0 0 2 2 2 1 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain CENP-B_dimeris PF09026.10 EXF76075.1 - 0.68 10.4 8.7 1.6 9.2 8.7 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Abhydrolase_3 PF07859.13 EXF76076.1 - 3.1e-41 141.6 0.0 3e-31 108.9 0.0 2.4 2 0 0 2 2 2 2 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 EXF76076.1 - 3.6e-14 52.4 0.0 6.1e-14 51.7 0.0 1.3 1 0 0 1 1 1 1 Steryl acetyl hydrolase COesterase PF00135.28 EXF76076.1 - 0.0029 16.5 0.0 0.056 12.3 0.0 2.1 2 0 0 2 2 2 1 Carboxylesterase family DUF966 PF06136.13 EXF76076.1 - 0.97 9.1 5.2 2.3 7.8 5.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF966) MRP-L27 PF09809.9 EXF76077.1 - 5.2e-18 64.9 0.4 7.9e-18 64.3 0.4 1.4 1 1 0 1 1 1 1 Mitochondrial ribosomal protein L27 THOC7 PF05615.13 EXF76078.1 - 0.0005 20.4 3.3 0.00065 20.0 3.3 1.2 1 0 0 1 1 1 1 Tho complex subunit 7 Head-tail_con PF12236.8 EXF76078.1 - 0.0027 16.2 0.2 0.0033 15.9 0.2 1.2 1 0 0 1 1 1 1 Bacteriophage head to tail connecting protein TPR_MLP1_2 PF07926.12 EXF76078.1 - 0.013 15.6 3.2 0.013 15.6 3.2 1.5 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein DUF4200 PF13863.6 EXF76078.1 - 0.18 12.2 9.0 0.16 12.4 7.9 1.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) KxDL PF10241.9 EXF76078.1 - 0.33 11.3 5.2 1.1 9.5 0.8 2.8 3 0 0 3 3 3 0 Uncharacterized conserved protein Rx_N PF18052.1 EXF76078.1 - 6.4 7.1 8.2 0.63 10.3 0.9 2.4 2 1 1 3 3 3 0 Rx N-terminal domain RNase_H PF00075.24 EXF76079.1 - 1.5e-07 31.6 0.3 4.6e-07 30.1 0.3 1.8 1 1 0 1 1 1 1 RNase H RVT_3 PF13456.6 EXF76079.1 - 0.005 16.7 0.0 4.5 7.1 0.0 2.8 2 1 1 3 3 3 2 Reverse transcriptase-like Peptidase_S8 PF00082.22 EXF76080.1 - 5.7e-44 150.6 0.2 8.6e-44 150.0 0.2 1.2 1 0 0 1 1 1 1 Subtilase family fn3_5 PF06280.12 EXF76080.1 - 3.9e-08 34.0 0.0 1.4e-07 32.2 0.0 1.9 2 0 0 2 2 2 1 Fn3-like domain Alpha-amylase PF00128.24 EXF76081.1 - 1.7e-23 83.8 6.3 1.2e-21 77.7 2.9 3.0 2 1 0 2 2 2 1 Alpha amylase, catalytic domain Glyco_transf_5 PF08323.11 EXF76081.1 - 2.3e-16 60.3 0.5 3.8e-16 59.5 0.5 1.3 1 0 0 1 1 1 1 Starch synthase catalytic domain Glycos_transf_1 PF00534.20 EXF76081.1 - 1.8e-06 27.6 0.0 3.5e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 EXF76081.1 - 0.0071 16.4 0.0 0.015 15.3 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Alpha-amylase PF00128.24 EXF76082.1 - 1.1e-50 173.1 0.7 1.7e-50 172.5 0.7 1.2 1 0 0 1 1 1 1 Alpha amylase, catalytic domain DUF1966 PF09260.11 EXF76082.1 - 3.4e-24 84.9 0.6 6.6e-24 84.0 0.6 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1966) Fungal_trans PF04082.18 EXF76083.1 - 4.5e-14 52.1 0.3 9.1e-14 51.1 0.3 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 EXF76083.1 - 4.6e-10 39.4 12.7 0.00014 22.1 0.2 3.6 3 0 0 3 3 3 2 Zinc finger, C2H2 type Zn_clus PF00172.18 EXF76083.1 - 7.8e-07 29.1 11.0 7.8e-07 29.1 11.0 2.1 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-C2H2_4 PF13894.6 EXF76083.1 - 9.7e-06 26.0 15.4 0.0041 17.8 0.1 3.6 3 0 0 3 3 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EXF76083.1 - 0.0016 18.7 0.3 0.0016 18.7 0.3 3.1 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_11 PF16622.5 EXF76083.1 - 0.012 15.3 6.3 1.9 8.3 2.7 3.0 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-met PF12874.7 EXF76083.1 - 0.016 15.6 2.5 4 8.0 0.8 3.3 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-MYST PF17772.1 EXF76083.1 - 0.029 14.0 0.9 1.2 8.8 0.1 2.9 3 0 0 3 3 3 0 MYST family zinc finger domain zf-C2H2_jaz PF12171.8 EXF76083.1 - 0.18 12.1 9.5 0.62 10.4 0.1 3.4 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.12 EXF76083.1 - 0.46 10.8 3.6 2.2 8.6 3.5 2.1 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.6 EXF76083.1 - 0.78 9.8 3.4 0.24 11.5 0.1 1.9 2 0 0 2 2 2 0 C2H2-type zinc finger MFS_1 PF07690.16 EXF76085.1 - 2.7e-35 121.9 37.9 5.1e-35 121.0 30.7 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF76085.1 - 4.7e-15 55.4 11.1 4.7e-15 55.4 11.1 3.0 2 2 1 3 3 3 1 Sugar (and other) transporter Fzo_mitofusin PF04799.13 EXF76085.1 - 0.072 12.6 0.2 0.13 11.8 0.2 1.3 1 0 0 1 1 1 0 fzo-like conserved region Fungal_trans PF04082.18 EXF76086.1 - 1e-08 34.5 0.0 1.6e-08 34.0 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF76086.1 - 2.1e-06 27.8 10.3 4e-06 26.8 10.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF3395 PF11875.8 EXF76087.1 - 8.9e-28 97.2 0.0 1.6e-27 96.4 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3395) DnaJ PF00226.31 EXF76087.1 - 1.6e-08 34.5 0.1 2.9e-08 33.7 0.1 1.4 1 0 0 1 1 1 1 DnaJ domain Fungal_trans PF04082.18 EXF76089.1 - 2.1e-22 79.5 0.0 3.5e-22 78.7 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF76089.1 - 3.8e-08 33.3 13.0 3.8e-08 33.3 13.0 2.1 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RVT_1 PF00078.27 EXF76091.1 - 1.2e-23 83.8 0.0 5.7e-23 81.6 0.0 2.0 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 EXF76091.1 - 3.3e-08 33.4 0.2 3.1e-07 30.3 0.2 2.5 1 1 0 1 1 1 1 Endonuclease-reverse transcriptase Med17 PF10156.9 EXF76092.1 - 5.5e-88 295.7 0.0 7e-88 295.3 0.0 1.1 1 0 0 1 1 1 1 Subunit 17 of Mediator complex SNF2_N PF00176.23 EXF76093.1 - 4.3e-61 206.6 0.8 1.1e-60 205.2 0.5 1.6 1 1 1 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EXF76093.1 - 3.2e-15 56.4 0.0 8.3e-15 55.1 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-C3HC4 PF00097.25 EXF76093.1 - 9.8e-08 31.7 5.1 1.9e-07 30.8 5.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EXF76093.1 - 1e-07 31.8 2.9 2.2e-07 30.7 2.9 1.6 1 0 0 1 1 1 1 RING-type zinc-finger ResIII PF04851.15 EXF76093.1 - 3.9e-07 30.2 0.0 1.3e-06 28.6 0.0 1.9 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit zf-C3HC4_2 PF13923.6 EXF76093.1 - 8.1e-07 28.8 2.3 8.1e-07 28.8 2.3 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EXF76093.1 - 1.1e-05 25.7 5.2 2.7e-05 24.4 5.2 1.7 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 EXF76093.1 - 8.7e-05 22.3 4.5 0.00019 21.2 4.5 1.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) DEAD PF00270.29 EXF76093.1 - 0.00018 21.3 3.1 0.00027 20.8 0.5 2.4 2 1 0 2 2 2 1 DEAD/DEAH box helicase zf-C3HC4_4 PF15227.6 EXF76093.1 - 0.00021 21.4 5.0 0.00046 20.3 5.0 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 EXF76093.1 - 0.00045 20.1 4.1 0.00086 19.2 4.1 1.5 1 0 0 1 1 1 1 zinc-RING finger domain ERCC3_RAD25_C PF16203.5 EXF76093.1 - 0.026 13.8 0.8 0.049 12.8 0.0 1.8 2 0 0 2 2 2 0 ERCC3/RAD25/XPB C-terminal helicase zf-WRNIP1_ubi PF18279.1 EXF76093.1 - 0.28 11.9 3.1 2.3 9.0 0.5 2.8 2 0 0 2 2 2 0 Werner helicase-interacting protein 1 ubiquitin-binding domain zf-RING_10 PF16685.5 EXF76093.1 - 0.43 10.7 2.3 1.2 9.4 2.3 1.7 1 0 0 1 1 1 0 zinc RING finger of MSL2 Hid1 PF12722.7 EXF76093.1 - 0.59 8.2 3.5 1.1 7.3 3.5 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Prok-RING_4 PF14447.6 EXF76093.1 - 6.5 6.7 6.8 44 4.0 7.1 2.2 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 ketoacyl-synt PF00109.26 EXF76094.1 - 7e-76 255.2 0.1 1.5e-75 254.0 0.1 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 EXF76094.1 - 1.1e-53 182.8 0.0 1.8e-53 182.1 0.0 1.3 1 0 0 1 1 1 1 Acyl transferase domain PS-DH PF14765.6 EXF76094.1 - 3.7e-51 174.1 0.0 6e-51 173.5 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase KR PF08659.10 EXF76094.1 - 8.6e-45 152.8 0.2 2.7e-44 151.2 0.2 1.9 1 0 0 1 1 1 1 KR domain Ketoacyl-synt_C PF02801.22 EXF76094.1 - 3.1e-34 117.5 0.3 9.4e-34 116.0 0.1 2.0 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 EXF76094.1 - 1.8e-19 70.2 0.5 1.2e-18 67.6 0.1 2.7 3 1 0 3 3 2 1 Ketoacyl-synthetase C-terminal extension adh_short PF00106.25 EXF76094.1 - 8.6e-11 41.7 0.0 3.1e-10 39.8 0.0 2.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF76094.1 - 4.6e-08 32.9 1.3 8.1e-08 32.1 0.1 2.0 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase Thiolase_N PF00108.23 EXF76094.1 - 0.0002 20.8 0.2 0.00046 19.6 0.2 1.5 1 0 0 1 1 1 1 Thiolase, N-terminal domain ADH_N PF08240.12 EXF76094.1 - 0.0005 19.9 0.4 0.0012 18.8 0.4 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EXF76094.1 - 0.0026 17.7 0.5 0.024 14.6 0.0 2.9 4 0 0 4 4 4 1 Zinc-binding dehydrogenase ACP_syn_III PF08545.10 EXF76094.1 - 0.056 13.3 0.9 0.27 11.1 0.9 2.2 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III NAD_binding_3 PF03447.16 EXF76094.1 - 0.07 13.8 0.1 15 6.3 0.2 3.4 3 0 0 3 3 3 0 Homoserine dehydrogenase, NAD binding domain MFS_1 PF07690.16 EXF76095.1 - 1.3e-27 96.7 46.0 5.8e-26 91.3 45.2 3.0 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EXF76095.1 - 8.7e-07 27.7 15.0 1.4e-06 27.1 15.0 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) OATP PF03137.20 EXF76095.1 - 3.2 5.9 13.7 0.9 7.8 4.6 3.1 3 1 0 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family HET PF06985.11 EXF76096.1 - 3.2e-10 40.5 4.7 8.3e-08 32.7 0.4 2.5 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) RRM_1 PF00076.22 EXF76097.1 - 4.7e-14 51.9 0.0 8.6e-14 51.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Presenilin PF01080.17 EXF76097.1 - 1.4 7.6 13.5 3.6 6.2 13.1 1.9 2 0 0 2 2 2 0 Presenilin Asp-B-Hydro_N PF05279.11 EXF76097.1 - 1.8 8.5 23.8 2.9 7.9 23.8 1.3 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region DUF4407 PF14362.6 EXF76097.1 - 6.5 6.0 13.4 9.2 5.5 13.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) GTP_EFTU PF00009.27 EXF76098.1 - 9.7e-59 198.2 0.0 1.5e-58 197.6 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 EXF76098.1 - 6.8e-16 58.1 0.0 1.7e-15 56.8 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.6 EXF76098.1 - 2.6e-07 30.6 0.0 5.6e-07 29.6 0.0 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 EXF76098.1 - 5.5e-07 29.9 0.0 1.8e-06 28.3 0.0 1.9 2 0 0 2 2 2 1 Elongation factor Tu domain 2 EFG_IV PF03764.18 EXF76098.1 - 6.9e-05 22.6 0.0 0.0009 19.0 0.0 2.7 3 0 0 3 3 3 1 Elongation factor G, domain IV MMR_HSR1 PF01926.23 EXF76098.1 - 0.032 14.3 0.0 0.1 12.7 0.0 1.9 1 1 0 1 1 1 0 50S ribosome-binding GTPase Paf67 PF10255.9 EXF76099.1 - 6e-156 519.5 0.3 7.2e-156 519.2 0.3 1.1 1 0 0 1 1 1 1 RNA polymerase I-associated factor PAF67 TPR_2 PF07719.17 EXF76099.1 - 0.02 15.0 0.0 0.11 12.7 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.28 EXF76099.1 - 0.068 13.0 0.0 0.35 10.8 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat Usp PF00582.26 EXF76101.1 - 5.8e-16 59.3 0.4 1.6e-15 57.9 0.0 1.9 2 0 0 2 2 2 1 Universal stress protein family ABA_GPCR PF12430.8 EXF76103.1 - 1.1e-60 204.5 0.4 1.3e-60 204.2 0.4 1.1 1 0 0 1 1 1 1 Abscisic acid G-protein coupled receptor M20_dimer PF07687.14 EXF76104.1 - 3.4e-07 30.2 0.0 7.3e-07 29.1 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M20 PF01546.28 EXF76104.1 - 0.00017 21.4 0.0 0.00054 19.7 0.0 1.9 2 0 0 2 2 2 1 Peptidase family M20/M25/M40 MFS_1 PF07690.16 EXF76106.1 - 1.3e-31 109.8 34.5 1.7e-31 109.4 34.5 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_4 PF06779.14 EXF76106.1 - 2.4e-05 23.8 18.6 0.00014 21.3 8.7 2.2 2 0 0 2 2 2 2 Uncharacterised MFS-type transporter YbfB DUF4131 PF13567.6 EXF76106.1 - 0.3 10.7 7.4 0.1 12.3 3.5 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4131) DUF1270 PF06900.11 EXF76106.1 - 0.42 11.0 4.9 8.4 6.9 0.3 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1270) Lipase_GDSL_2 PF13472.6 EXF76107.1 - 2.6e-19 70.3 0.0 3.7e-19 69.8 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EXF76107.1 - 5.5e-10 39.6 0.0 1.3e-09 38.4 0.0 1.5 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Activator-TraM PF11657.8 EXF76107.1 - 0.16 11.8 0.0 0.28 11.0 0.0 1.2 1 0 0 1 1 1 0 Transcriptional activator TraM F-box-like PF12937.7 EXF76109.1 - 6.4e-05 22.8 0.1 0.00022 21.0 0.1 2.0 1 1 0 1 1 1 1 F-box-like F-box PF00646.33 EXF76109.1 - 0.13 12.2 0.9 1.3 9.0 0.2 2.4 2 0 0 2 2 2 0 F-box domain Zn_clus PF00172.18 EXF76110.1 - 1.9e-08 34.3 8.2 4e-08 33.3 8.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain F-box-like PF12937.7 EXF76111.1 - 0.0054 16.6 0.8 0.014 15.3 0.1 2.0 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EXF76111.1 - 0.13 12.2 1.0 0.62 10.0 0.0 2.6 3 0 0 3 3 3 0 F-box domain U79_P34 PF03064.16 EXF76112.1 - 7 5.9 8.2 16 4.7 8.2 1.6 1 0 0 1 1 1 0 HSV U79 / HCMV P34 PALP PF00291.25 EXF76113.1 - 1e-42 146.5 0.3 1.3e-42 146.2 0.3 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme LYTB PF02401.18 EXF76113.1 - 0.1 11.8 0.0 0.19 10.9 0.0 1.4 1 0 0 1 1 1 0 LytB protein TauD PF02668.16 EXF76114.1 - 2.3e-33 116.1 0.1 3.4e-33 115.6 0.1 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family CsiD PF08943.10 EXF76114.1 - 0.064 12.4 0.0 0.1 11.7 0.0 1.4 1 1 0 1 1 1 0 CsiD DUF917 PF06032.12 EXF76115.1 - 1.1e-121 406.0 1.1 1.1e-121 406.0 1.1 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF917) Hydant_A_N PF05378.13 EXF76115.1 - 4.4e-32 111.2 0.0 4.2e-29 101.5 0.0 2.8 3 0 0 3 3 3 2 Hydantoinase/oxoprolinase N-terminal region Hydantoinase_A PF01968.18 EXF76115.1 - 8.3e-30 104.0 8.3 3.2e-28 98.8 0.5 3.3 3 0 0 3 3 3 2 Hydantoinase/oxoprolinase MutL PF13941.6 EXF76115.1 - 0.00024 19.8 4.5 0.0062 15.2 0.0 3.2 3 0 0 3 3 3 1 MutL protein StbA PF06406.11 EXF76115.1 - 0.024 13.9 0.2 8.6 5.5 0.0 2.8 2 1 1 3 3 3 0 StbA protein BcrAD_BadFG PF01869.20 EXF76115.1 - 0.04 13.4 1.6 0.2 11.1 0.0 2.9 3 1 0 3 3 3 0 BadF/BadG/BcrA/BcrD ATPase family FtsA PF14450.6 EXF76115.1 - 0.063 13.7 1.9 13 6.2 0.1 2.8 2 0 0 2 2 2 0 Cell division protein FtsA Transp_cyt_pur PF02133.15 EXF76116.1 - 8.1e-91 305.0 36.7 9.5e-91 304.8 36.7 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin HNH_2 PF13391.6 EXF76117.1 - 6e-10 39.1 0.0 3.1e-09 36.8 0.0 2.1 2 0 0 2 2 2 1 HNH endonuclease Fungal_trans PF04082.18 EXF76118.1 - 8.2e-32 110.3 0.0 1.4e-31 109.6 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Amidohydro_2 PF04909.14 EXF76119.1 - 4.6e-29 102.1 0.2 6.3e-29 101.7 0.2 1.2 1 0 0 1 1 1 1 Amidohydrolase FAD_binding_4 PF01565.23 EXF76121.1 - 1.5e-15 57.2 1.0 5.7e-15 55.3 1.0 1.8 2 0 0 2 2 2 1 FAD binding domain Strep_SA_rep PF06696.11 EXF76122.1 - 0.025 14.6 1.7 0.057 13.4 1.7 1.6 1 0 0 1 1 1 0 Streptococcal surface antigen repeat AAA PF00004.29 EXF76123.1 - 2.9e-10 40.7 0.9 4.2e-10 40.2 0.0 1.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EXF76123.1 - 0.046 14.1 0.1 0.18 12.2 0.0 2.0 1 1 0 1 1 1 0 AAA ATPase domain AAA_24 PF13479.6 EXF76123.1 - 0.077 12.7 0.2 0.24 11.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 EXF76123.1 - 0.084 13.1 0.1 0.37 11.0 0.0 1.9 1 1 0 2 2 2 0 AAA domain AAA_5 PF07728.14 EXF76123.1 - 0.11 12.5 0.0 0.23 11.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Peptidase_M43 PF05572.13 EXF76125.1 - 3.7e-13 49.7 0.6 9.2e-13 48.4 0.2 2.0 1 1 1 2 2 2 1 Pregnancy-associated plasma protein-A Reprolysin_5 PF13688.6 EXF76125.1 - 5.6e-05 23.4 1.1 8.7e-05 22.8 1.1 1.4 1 1 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_4 PF13583.6 EXF76125.1 - 0.00075 19.2 0.2 0.0015 18.2 0.0 1.6 2 0 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 EXF76125.1 - 0.0048 16.8 0.1 0.011 15.7 0.1 1.9 2 0 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.24 EXF76125.1 - 0.0074 16.1 0.0 0.0087 15.9 0.0 1.3 1 0 0 1 1 1 1 Matrixin Reprolysin_3 PF13582.6 EXF76125.1 - 0.051 14.1 1.9 0.13 12.7 1.9 1.9 1 1 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_M66 PF10462.9 EXF76125.1 - 0.12 11.3 3.4 0.14 11.1 2.1 1.6 1 1 0 1 1 1 0 Peptidase M66 DUF4953 PF16313.5 EXF76125.1 - 0.29 10.3 0.7 0.47 9.6 0.7 1.2 1 0 0 1 1 1 0 Met-zincin FAD_binding_3 PF01494.19 EXF76126.1 - 3.9e-22 79.0 0.0 2.9e-21 76.1 0.0 2.0 1 1 0 1 1 1 1 FAD binding domain Amino_oxidase PF01593.24 EXF76126.1 - 0.006 15.9 0.1 0.11 11.7 0.0 2.1 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase Lycopene_cycl PF05834.12 EXF76126.1 - 0.0072 15.4 0.3 1.9 7.4 0.1 2.6 3 0 0 3 3 3 2 Lycopene cyclase protein NAD_binding_8 PF13450.6 EXF76126.1 - 0.024 14.9 0.3 0.085 13.1 0.3 2.0 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Trp_halogenase PF04820.14 EXF76126.1 - 0.029 13.2 0.3 0.54 9.1 0.0 2.5 3 0 0 3 3 3 0 Tryptophan halogenase Pyr_redox_3 PF13738.6 EXF76126.1 - 0.06 12.6 3.2 0.41 9.9 0.5 2.5 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Glyco_hydro_43 PF04616.14 EXF76127.1 - 5.5e-32 111.2 0.4 7.4e-32 110.8 0.4 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 GspH PF12019.8 EXF76127.1 - 1.7 9.1 4.9 1.5 9.3 0.1 3.0 3 1 1 4 4 4 0 Type II transport protein GspH Big_9 PF17963.1 EXF76128.1 - 0.072 13.8 0.3 0.072 13.8 0.3 3.3 3 0 0 3 3 3 0 Bacterial Ig domain Acetyltransf_1 PF00583.25 EXF76129.1 - 6e-07 29.7 0.0 7.4e-07 29.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EXF76129.1 - 3.7e-06 26.9 0.0 5.1e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EXF76129.1 - 5.1e-06 26.8 0.0 7.4e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain EF-hand_4 PF12763.7 EXF76130.1 - 0.008 16.1 0.0 0.016 15.2 0.0 1.4 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand MAP65_ASE1 PF03999.12 EXF76131.1 - 8.3e-72 242.7 26.9 1.4e-71 242.0 25.6 2.0 1 1 0 1 1 1 1 Microtubule associated protein (MAP65/ASE1 family) Spectrin PF00435.21 EXF76131.1 - 0.028 14.9 1.5 0.028 14.9 1.5 4.1 3 1 0 4 4 4 0 Spectrin repeat BAR_3 PF16746.5 EXF76131.1 - 0.078 12.7 7.7 0.28 10.9 2.8 2.6 2 0 0 2 2 2 0 BAR domain of APPL family AAA_13 PF13166.6 EXF76131.1 - 1.2 7.7 10.1 0.077 11.6 4.7 1.6 2 0 0 2 2 2 0 AAA domain DUF4407 PF14362.6 EXF76131.1 - 5.7 6.2 9.6 2 7.7 3.4 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4407) Herpes_UL6 PF01763.16 EXF76131.1 - 9.7 4.6 7.1 2.9 6.3 1.3 2.2 2 0 0 2 2 2 0 Herpesvirus UL6 like Polysacc_lyase PF14099.6 EXF76132.1 - 3.6e-49 167.5 6.1 4.3e-49 167.2 6.1 1.0 1 0 0 1 1 1 1 Polysaccharide lyase FapA PF03961.13 EXF76133.1 - 0.026 13.2 0.0 0.05 12.2 0.0 1.4 1 0 0 1 1 1 0 Flagellar Assembly Protein A UDPG_MGDP_dh PF00984.19 EXF76134.1 - 3.1e-19 69.0 0.0 7e-19 67.8 0.0 1.6 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain UDPG_MGDP_dh_N PF03721.14 EXF76134.1 - 3.5e-19 69.1 0.1 1.1e-16 60.9 0.1 2.2 1 1 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_binding_2 PF03446.15 EXF76134.1 - 4.4e-06 27.0 0.0 8.1e-06 26.1 0.0 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase TrkA_N PF02254.18 EXF76134.1 - 0.0017 18.6 0.0 0.0033 17.7 0.0 1.5 1 0 0 1 1 1 1 TrkA-N domain F420_oxidored PF03807.17 EXF76134.1 - 0.042 14.4 0.1 0.37 11.4 0.0 2.5 2 1 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent Methyltransf_25 PF13649.6 EXF76134.1 - 0.064 14.0 0.0 0.16 12.7 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain 3HCDH_N PF02737.18 EXF76134.1 - 0.11 12.3 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Chitin_synth_2 PF03142.15 EXF76135.1 - 2.5e-27 95.7 0.1 4.6e-23 81.6 0.1 2.3 1 1 1 2 2 2 2 Chitin synthase Glyco_tranf_2_3 PF13641.6 EXF76135.1 - 1.9e-10 41.1 0.1 3.1e-10 40.3 0.1 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 EXF76135.1 - 1e-09 38.6 1.2 2.2e-09 37.5 1.2 1.6 1 0 0 1 1 1 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.26 EXF76135.1 - 1.9e-05 24.5 0.0 0.097 12.5 0.0 3.0 2 1 0 2 2 2 2 Glycosyl transferase family 2 HET PF06985.11 EXF76140.1 - 3.2e-33 115.1 0.1 4.8e-33 114.6 0.1 1.3 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) MBD PF01429.19 EXF76140.1 - 0.13 11.9 1.0 2.2 8.0 0.0 2.9 3 0 0 3 3 3 0 Methyl-CpG binding domain DUF2594 PF10769.9 EXF76141.1 - 0.068 13.2 3.2 69 3.6 0.0 4.1 4 0 0 4 4 4 0 Protein of unknown function (DUF2594) V4R PF02830.18 EXF76141.1 - 0.54 10.3 22.4 19 5.4 1.7 5.3 3 2 2 5 5 5 0 V4R domain COPR5 PF15340.6 EXF76141.1 - 0.54 10.9 1.9 1.8 9.2 0.9 2.6 2 1 0 2 2 2 0 Cooperator of PRMT5 family Phage_Coat_B PF05356.11 EXF76141.1 - 3.4 7.7 7.0 1.1 9.2 2.4 2.4 2 1 1 3 3 3 0 Phage Coat protein B Asparaginase_2 PF01112.18 EXF76142.1 - 5.9e-65 219.3 6.0 4.3e-53 180.3 2.3 2.3 2 0 0 2 2 2 2 Asparaginase ToxB_N PF18224.1 EXF76144.1 - 1.6e-27 95.2 2.3 1.9e-27 94.9 2.3 1.1 1 0 0 1 1 1 1 ToxB N-terminal domain AAA_18 PF13238.6 EXF76145.1 - 5.6e-06 26.9 0.0 1.2e-05 25.9 0.0 1.5 1 1 0 1 1 1 1 AAA domain CPT PF07931.12 EXF76145.1 - 0.00016 21.6 0.0 0.022 14.6 0.0 2.2 2 0 0 2 2 2 2 Chloramphenicol phosphotransferase-like protein AAA_33 PF13671.6 EXF76145.1 - 0.00051 20.2 0.0 0.00076 19.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.10 EXF76145.1 - 0.0017 17.9 0.0 0.0027 17.2 0.0 1.5 1 1 0 1 1 1 1 Chromatin associated protein KTI12 AAA_16 PF13191.6 EXF76145.1 - 0.017 15.5 0.0 0.037 14.4 0.0 1.7 1 1 0 1 1 1 0 AAA ATPase domain AAA PF00004.29 EXF76145.1 - 0.043 14.2 0.0 0.25 11.8 0.0 2.0 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) APS_kinase PF01583.20 EXF76145.1 - 0.052 13.4 0.0 0.14 12.0 0.0 1.7 1 1 1 2 2 2 0 Adenylylsulphate kinase Sigma54_activ_2 PF14532.6 EXF76145.1 - 0.065 13.4 0.0 0.32 11.1 0.0 1.9 1 1 0 2 2 2 0 Sigma-54 interaction domain AAA_22 PF13401.6 EXF76145.1 - 0.07 13.4 0.0 0.12 12.6 0.0 1.5 1 1 0 1 1 1 0 AAA domain MG3 PF17791.1 EXF76145.1 - 0.2 12.0 0.0 0.29 11.4 0.0 1.3 1 0 0 1 1 1 0 Macroglobulin domain MG3 tRNA-synt_2 PF00152.20 EXF76146.1 - 5.6e-23 81.5 0.0 7e-23 81.2 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA-synt_2d PF01409.20 EXF76146.1 - 0.019 14.4 0.0 5.3 6.5 0.0 2.2 2 0 0 2 2 2 0 tRNA synthetases class II core domain (F) Toxin_37 PF11415.8 EXF76146.1 - 0.023 14.5 0.8 0.059 13.2 0.3 1.9 2 0 0 2 2 2 0 Antifungal peptide termicin DUF3328 PF11807.8 EXF76147.1 - 1.5e-26 93.6 0.1 1.9e-26 93.2 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) PDZ_2 PF13180.6 EXF76147.1 - 0.083 13.2 0.0 0.18 12.1 0.0 1.5 1 0 0 1 1 1 0 PDZ domain nlz1 PF12402.8 EXF76147.1 - 0.1 13.1 0.0 0.46 10.9 0.0 2.0 2 0 0 2 2 2 0 NocA-like zinc-finger protein 1 FAD_binding_3 PF01494.19 EXF76148.1 - 6.4e-15 55.2 0.0 4.1e-13 49.3 0.0 2.8 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 EXF76148.1 - 2.4e-06 27.7 0.0 6.3e-06 26.3 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 EXF76148.1 - 0.0044 17.5 0.0 0.018 15.6 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NUC PF18510.1 EXF76148.1 - 0.0063 17.0 0.0 0.01 16.3 0.0 1.3 1 0 0 1 1 1 1 Nuclease domain Pyr_redox_3 PF13738.6 EXF76148.1 - 0.0068 15.7 0.0 0.4 9.9 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EXF76148.1 - 0.0069 16.0 0.1 0.074 12.6 0.0 2.0 1 1 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EXF76148.1 - 0.0094 15.1 0.1 0.017 14.2 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 EXF76148.1 - 0.022 14.0 0.0 0.037 13.3 0.0 1.3 1 0 0 1 1 1 0 Thi4 family Pyr_redox_2 PF07992.14 EXF76148.1 - 0.07 12.4 0.0 0.16 11.2 0.0 1.6 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 EXF76148.1 - 0.13 11.5 0.3 16 4.6 0.0 2.5 3 0 0 3 3 3 0 Flavin containing amine oxidoreductase TrkA_N PF02254.18 EXF76148.1 - 0.19 12.0 0.0 0.43 10.8 0.0 1.6 1 0 0 1 1 1 0 TrkA-N domain Peptidase_M43 PF05572.13 EXF76150.1 - 2e-13 50.5 0.1 3.3e-13 49.8 0.1 1.4 1 1 0 1 1 1 1 Pregnancy-associated plasma protein-A Metallopep PF12044.8 EXF76150.1 - 0.0011 17.7 0.1 0.0015 17.2 0.1 1.1 1 0 0 1 1 1 1 Putative peptidase family Reprolysin_5 PF13688.6 EXF76150.1 - 0.0012 19.0 1.5 0.0026 18.0 1.5 1.7 1 1 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.6 EXF76150.1 - 0.0018 18.8 0.1 0.01 16.3 0.0 2.0 2 0 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 EXF76150.1 - 0.0048 16.6 0.0 0.0098 15.6 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.24 EXF76150.1 - 0.015 15.1 0.0 0.02 14.7 0.0 1.3 1 0 0 1 1 1 0 Matrixin DUF4953 PF16313.5 EXF76150.1 - 0.035 13.3 0.1 0.058 12.6 0.1 1.3 1 0 0 1 1 1 0 Met-zincin Peptidase_M66 PF10462.9 EXF76150.1 - 0.052 12.5 0.1 0.075 12.0 0.1 1.2 1 0 0 1 1 1 0 Peptidase M66 Reprolysin_2 PF13574.6 EXF76150.1 - 0.066 13.1 0.1 0.12 12.3 0.1 1.5 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like DUF3455 PF11937.8 EXF76151.1 - 4.1e-31 108.5 0.1 5.2e-31 108.2 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3455) Pkinase PF00069.25 EXF76152.1 - 4.6e-69 232.7 0.0 5.4e-69 232.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF76152.1 - 1.1e-31 110.1 0.0 1.5e-31 109.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EXF76152.1 - 0.0088 15.0 0.0 0.016 14.2 0.0 1.4 1 1 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EXF76152.1 - 0.042 13.2 0.1 0.085 12.2 0.1 1.5 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EXF76152.1 - 0.059 13.3 0.0 0.17 11.8 0.0 1.7 1 0 0 1 1 1 0 Phosphotransferase enzyme family LMWPc PF01451.21 EXF76153.1 - 8.6e-40 136.4 0.0 9.7e-40 136.2 0.0 1.0 1 0 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase CFEM PF05730.11 EXF76154.1 - 4.2e-11 42.8 12.0 6.8e-11 42.1 12.0 1.3 1 0 0 1 1 1 1 CFEM domain Pox_A12 PF04651.13 EXF76154.1 - 0.14 12.3 3.9 0.17 11.9 3.9 1.2 1 0 0 1 1 1 0 Poxvirus A12 protein Herpes_capsid PF06112.11 EXF76154.1 - 4.2 7.4 21.0 5.8 6.9 21.0 1.2 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein 4HBT_2 PF13279.6 EXF76155.1 - 8.7e-06 26.2 0.0 1.4e-05 25.6 0.0 1.3 1 0 0 1 1 1 1 Thioesterase-like superfamily Ank_2 PF12796.7 EXF76156.1 - 8.7e-20 71.1 0.0 4e-09 36.9 0.0 6.0 5 1 2 7 7 7 3 Ankyrin repeats (3 copies) Ank PF00023.30 EXF76156.1 - 8.9e-13 48.1 0.0 0.00035 20.9 0.0 5.2 5 0 0 5 5 4 3 Ankyrin repeat Ank_3 PF13606.6 EXF76156.1 - 5.7e-10 38.6 1.1 0.00068 19.9 0.0 6.3 6 1 0 6 6 4 1 Ankyrin repeat Ank_4 PF13637.6 EXF76156.1 - 8.4e-10 39.0 2.2 0.00062 20.3 0.0 5.2 3 1 3 6 6 6 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 EXF76156.1 - 1.1e-09 38.4 0.0 1.9e-05 24.8 0.0 4.0 3 1 0 3 3 3 2 Ankyrin repeats (many copies) AAA_16 PF13191.6 EXF76156.1 - 0.00013 22.4 0.0 0.00046 20.6 0.0 2.0 1 0 0 1 1 1 1 AAA ATPase domain NACHT PF05729.12 EXF76156.1 - 0.00017 21.6 0.0 0.00046 20.1 0.0 1.7 1 0 0 1 1 1 1 NACHT domain AAA_18 PF13238.6 EXF76156.1 - 0.0011 19.5 0.3 0.0054 17.3 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EXF76156.1 - 0.0027 18.0 0.0 0.009 16.3 0.0 1.9 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 EXF76156.1 - 0.0037 17.6 0.0 0.011 16.0 0.0 1.9 1 0 0 1 1 1 1 RNA helicase APS_kinase PF01583.20 EXF76156.1 - 0.0051 16.7 0.0 0.0094 15.9 0.0 1.4 1 0 0 1 1 1 1 Adenylylsulphate kinase NTPase_1 PF03266.15 EXF76156.1 - 0.016 15.1 0.1 0.05 13.5 0.0 1.9 2 0 0 2 2 1 0 NTPase AAA_33 PF13671.6 EXF76156.1 - 0.021 15.0 0.0 0.054 13.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 EXF76156.1 - 0.022 14.8 0.0 0.079 13.0 0.0 1.9 2 0 0 2 2 2 0 50S ribosome-binding GTPase KTI12 PF08433.10 EXF76156.1 - 0.051 13.0 0.0 0.093 12.2 0.0 1.3 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_25 PF13481.6 EXF76156.1 - 0.066 12.8 0.0 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain MeaB PF03308.16 EXF76156.1 - 0.078 12.0 0.0 0.14 11.2 0.0 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA PF00004.29 EXF76156.1 - 0.16 12.4 0.0 0.38 11.2 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.6 EXF76156.1 - 0.17 12.3 0.0 0.38 11.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain ArabFuran-catal PF09206.11 EXF76157.1 - 1.8e-150 500.6 12.3 3e-150 499.9 12.3 1.4 1 0 0 1 1 1 1 Alpha-L-arabinofuranosidase B, catalytic AbfB PF05270.13 EXF76157.1 - 1.1e-55 187.5 5.5 1.6e-55 186.9 5.5 1.3 1 0 0 1 1 1 1 Alpha-L-arabinofuranosidase B (ABFB) domain MBOAT_2 PF13813.6 EXF76158.1 - 1.3e-07 31.7 5.6 3.1e-07 30.6 5.6 1.7 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family Acetyltransf_7 PF13508.7 EXF76159.1 - 1.6e-10 41.3 0.0 6.1e-10 39.4 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EXF76159.1 - 5.4e-10 39.3 0.0 1.1e-09 38.3 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EXF76159.1 - 1.5e-09 38.1 0.0 3e-09 37.1 0.0 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_9 PF13527.7 EXF76159.1 - 1.9e-07 31.2 0.1 9.8e-07 28.9 0.0 2.1 2 1 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EXF76159.1 - 9.9e-07 28.6 0.0 1.8e-06 27.8 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.6 EXF76159.1 - 0.0013 18.8 0.0 0.0038 17.3 0.0 1.7 2 0 0 2 2 2 1 GCN5-related N-acetyl-transferase GNAT_acetyltran PF12746.7 EXF76159.1 - 0.028 14.0 0.0 0.039 13.5 0.0 1.2 1 0 0 1 1 1 0 GNAT acetyltransferase DUF929 PF06053.11 EXF76159.1 - 0.21 10.9 0.0 0.28 10.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF929) SnoaL_2 PF12680.7 EXF76162.1 - 1.8e-06 28.5 0.0 2.5e-06 28.0 0.0 1.2 1 0 0 1 1 1 1 SnoaL-like domain SnoaL PF07366.12 EXF76162.1 - 0.002 17.9 0.0 0.24 11.2 0.0 2.2 2 0 0 2 2 2 2 SnoaL-like polyketide cyclase O-FucT PF10250.9 EXF76163.1 - 3.8e-15 56.4 0.0 1.1e-14 54.9 0.0 1.8 1 1 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase Glyco_hydro_18 PF00704.28 EXF76165.1 - 2.5e-59 201.5 2.1 3.7e-59 201.0 2.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 LysM PF01476.20 EXF76166.1 - 3.6e-09 36.5 6.4 0.13 12.4 0.0 7.0 7 0 0 7 7 7 5 LysM domain MFS_1 PF07690.16 EXF76168.1 - 3.1e-38 131.6 29.7 3.1e-38 131.6 29.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF76168.1 - 1e-13 51.0 9.2 1e-13 51.0 9.2 2.8 2 1 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 EXF76168.1 - 7.1e-09 34.6 2.4 7.1e-09 34.6 2.4 1.9 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) BT1 PF03092.16 EXF76168.1 - 0.0028 16.0 0.1 0.0081 14.4 0.1 1.8 1 0 0 1 1 1 1 BT1 family FAD_binding_3 PF01494.19 EXF76169.1 - 2.6e-19 69.7 0.0 3.5e-19 69.3 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 EXF76169.1 - 3.7e-08 33.5 3.1 1e-07 32.1 0.7 2.5 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EXF76169.1 - 2.9e-07 29.9 2.1 4.5e-07 29.3 0.5 1.9 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.14 EXF76169.1 - 2.2e-06 27.1 0.1 0.00015 21.1 0.2 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EXF76169.1 - 5.9e-06 26.1 2.6 0.0039 16.8 2.3 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase HI0933_like PF03486.14 EXF76169.1 - 7.2e-05 21.7 0.1 0.0005 18.9 0.2 1.9 2 0 0 2 2 2 1 HI0933-like protein FAD_oxidored PF12831.7 EXF76169.1 - 0.00012 21.6 0.0 0.00015 21.3 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EXF76169.1 - 0.00016 21.1 0.6 0.00024 20.5 0.6 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EXF76169.1 - 0.00021 20.5 0.2 0.15 11.1 0.0 2.1 2 0 0 2 2 2 2 Lycopene cyclase protein Pyr_redox PF00070.27 EXF76169.1 - 0.0021 18.6 0.3 0.011 16.3 0.6 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EXF76169.1 - 0.0099 15.0 0.3 0.015 14.4 0.3 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A Thi4 PF01946.17 EXF76169.1 - 0.038 13.2 0.2 0.063 12.5 0.2 1.3 1 0 0 1 1 1 0 Thi4 family FMO-like PF00743.19 EXF76169.1 - 0.096 11.1 0.2 0.13 10.6 0.2 1.1 1 0 0 1 1 1 0 Flavin-binding monooxygenase-like FAA_hydrolase PF01557.18 EXF76170.1 - 1.4e-59 201.4 0.0 1.7e-59 201.1 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family Homeobox_KN PF05920.11 EXF76171.1 - 3.2e-16 59.0 2.9 1.4e-15 56.9 2.9 2.3 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 EXF76171.1 - 4.8e-09 35.9 0.9 4.8e-09 35.9 0.9 2.0 2 0 0 2 2 2 1 Homeodomain zf-C2H2_4 PF13894.6 EXF76171.1 - 0.00071 20.2 18.6 0.00088 19.9 1.6 5.4 5 0 0 5 5 5 1 C2H2-type zinc finger HTH_Tnp_Tc5 PF03221.16 EXF76171.1 - 0.0083 16.1 0.0 1.2 9.2 0.0 3.5 3 0 0 3 3 3 1 Tc5 transposase DNA-binding domain zf-C2H2 PF00096.26 EXF76171.1 - 0.013 16.0 1.6 0.013 16.0 1.6 4.9 5 0 0 5 5 5 0 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 EXF76171.1 - 0.013 15.7 1.8 0.013 15.7 1.8 2.5 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Homez PF11569.8 EXF76171.1 - 0.038 13.5 0.0 0.13 11.8 0.0 1.9 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez BIR PF00653.21 EXF76171.1 - 1.8 9.3 8.6 0.69 10.6 0.1 3.0 2 1 1 3 3 3 0 Inhibitor of Apoptosis domain zf-C2H2_2 PF12756.7 EXF76171.1 - 3.3 8.1 9.2 18 5.7 0.2 3.3 2 1 1 3 3 3 0 C2H2 type zinc-finger (2 copies) PNGaseA PF12222.8 EXF76172.1 - 2.1e-147 491.5 2.4 2.8e-147 491.1 2.4 1.1 1 0 0 1 1 1 1 Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A ssDBP PF17878.1 EXF76172.1 - 0.041 14.1 0.1 0.12 12.6 0.1 1.7 1 0 0 1 1 1 0 Single-stranded DNA-binding protein Zn_clus PF00172.18 EXF76173.1 - 5.5e-10 39.2 4.6 1e-09 38.4 4.6 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EXF76173.1 - 0.14 10.9 0.8 0.8 8.5 0.2 2.0 1 1 0 2 2 2 0 Fungal specific transcription factor domain BTB PF00651.31 EXF76174.1 - 0.026 14.7 0.0 0.055 13.7 0.0 1.6 1 1 0 1 1 1 0 BTB/POZ domain DAO PF01266.24 EXF76176.1 - 1.3e-18 67.8 0.6 2e-18 67.1 0.1 1.6 2 0 0 2 2 2 1 FAD dependent oxidoreductase Formyl_trans_N PF00551.19 EXF76176.1 - 7.4e-10 38.8 0.0 1.4e-09 38.0 0.0 1.4 1 0 0 1 1 1 1 Formyl transferase NAD_binding_8 PF13450.6 EXF76176.1 - 7.7e-05 22.8 0.1 0.00029 21.0 0.0 2.0 2 0 0 2 2 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 EXF76176.1 - 0.00079 18.8 0.1 0.0041 16.4 0.0 2.1 3 0 0 3 3 3 1 FAD binding domain Pyr_redox PF00070.27 EXF76176.1 - 0.0014 19.1 0.0 0.35 11.5 0.0 2.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EXF76176.1 - 0.0017 17.6 0.0 1.1 8.4 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 EXF76176.1 - 0.037 13.9 0.0 0.064 13.1 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain HI0933_like PF03486.14 EXF76176.1 - 0.063 12.0 0.1 6 5.4 0.0 2.3 2 0 0 2 2 2 0 HI0933-like protein FAD_binding_2 PF00890.24 EXF76176.1 - 0.088 11.9 0.0 0.17 10.9 0.0 1.5 1 0 0 1 1 1 0 FAD binding domain Shikimate_DH PF01488.20 EXF76176.1 - 0.19 11.8 0.0 0.37 10.8 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase AlaDh_PNT_C PF01262.21 EXF76176.1 - 0.2 11.0 0.0 0.37 10.1 0.0 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain MFS_1 PF07690.16 EXF76177.1 - 6.2e-35 120.8 36.6 6.2e-35 120.8 36.6 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily GATase PF00117.28 EXF76178.1 - 3.5e-12 46.5 0.0 4.7e-12 46.1 0.0 1.1 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 EXF76178.1 - 0.0071 16.1 0.2 0.088 12.6 0.2 2.5 1 1 0 1 1 1 1 Peptidase C26 MCR_alpha_N PF02745.15 EXF76178.1 - 0.19 11.0 0.0 4.1 6.7 0.0 2.0 1 1 1 2 2 2 0 Methyl-coenzyme M reductase alpha subunit, N-terminal domain Sortilin-Vps10 PF15902.5 EXF76179.1 - 1.8e-14 53.4 5.1 0.00029 19.7 0.0 5.9 4 2 3 8 8 8 5 Sortilin, neurotensin receptor 3, CBM_1 PF00734.18 EXF76179.1 - 1.4e-12 47.4 16.6 3.8e-12 45.9 16.6 1.9 1 0 0 1 1 1 1 Fungal cellulose binding domain BNR PF02012.20 EXF76179.1 - 0.00071 19.2 35.6 1.7 9.0 0.1 9.8 10 0 0 10 10 10 3 BNR/Asp-box repeat BNR_6 PF15899.5 EXF76179.1 - 0.01 15.8 10.8 5.7 7.3 0.1 6.8 7 0 0 7 7 7 0 BNR-Asp box repeat Toxin_7 PF05980.12 EXF76179.1 - 0.012 15.9 2.2 0.02 15.1 2.2 1.3 1 0 0 1 1 1 0 Toxin 7 Kelch_4 PF13418.6 EXF76179.1 - 0.012 15.6 1.2 0.044 13.8 0.2 2.6 2 0 0 2 2 2 0 Galactose oxidase, central domain BNR_3 PF13859.6 EXF76179.1 - 0.024 13.9 1.7 3.3 6.9 0.0 4.3 3 1 1 4 4 4 0 BNR repeat-like domain Kelch_1 PF01344.25 EXF76179.1 - 0.037 13.6 0.8 0.11 12.1 0.2 2.2 2 0 0 2 2 2 0 Kelch motif Kelch_3 PF13415.6 EXF76179.1 - 0.064 13.6 0.5 0.064 13.6 0.5 4.1 5 1 0 5 5 5 0 Galactose oxidase, central domain BNR_2 PF13088.6 EXF76179.1 - 0.066 12.5 18.3 0.48 9.7 0.0 5.8 4 3 0 4 4 4 0 BNR repeat-like domain Paramyxo_P_V_N PF13825.6 EXF76179.1 - 5.9 6.2 13.2 11 5.3 13.2 1.3 1 0 0 1 1 1 0 Paramyxovirus structural protein V/P N-terminus Sugar_tr PF00083.24 EXF76180.1 - 1.5e-88 297.7 26.6 1.7e-88 297.5 26.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF76180.1 - 1.1e-36 126.5 22.9 1.1e-36 126.5 22.9 1.6 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EXF76180.1 - 8e-06 24.5 4.6 8e-06 24.5 4.6 1.7 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) OATP PF03137.20 EXF76180.1 - 0.00032 19.1 3.2 0.00032 19.1 3.2 3.5 1 1 1 3 3 3 3 Organic Anion Transporter Polypeptide (OATP) family Glyco_hydro_2_C PF02836.17 EXF76181.1 - 6.5e-101 337.4 0.1 1.1e-100 336.7 0.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Bgal_small_N PF02929.17 EXF76181.1 - 3e-64 216.9 0.0 5.6e-64 216.1 0.0 1.4 1 0 0 1 1 1 1 Beta galactosidase small chain Glyco_hydro_2_N PF02837.18 EXF76181.1 - 3.5e-40 137.7 0.3 7.3e-40 136.6 0.3 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain DUF4981 PF16353.5 EXF76181.1 - 1.1e-21 77.1 0.0 3.3e-21 75.6 0.0 1.9 1 0 0 1 1 1 1 Domain of unknown function(DUF4981) Glyco_hydro_2 PF00703.21 EXF76181.1 - 1.6e-11 44.9 0.1 1.5e-10 41.7 0.0 2.4 2 0 0 2 2 2 1 Glycosyl hydrolases family 2 BetaGal_dom4_5 PF13364.6 EXF76181.1 - 0.019 15.5 0.0 0.06 13.9 0.0 1.8 1 0 0 1 1 1 0 Beta-galactosidase jelly roll domain Lipoprotein_Ltp PF07553.11 EXF76182.1 - 0.19 12.0 0.0 0.35 11.1 0.0 1.4 1 0 0 1 1 1 0 Host cell surface-exposed lipoprotein Mito_carr PF00153.27 EXF76183.1 - 2.5e-38 129.9 7.5 3.2e-16 59.0 0.4 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Fungal_trans_2 PF11951.8 EXF76184.1 - 1.4e-17 63.6 0.1 2.3e-17 62.9 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Aminotran_4 PF01063.19 EXF76185.1 - 4.6e-20 72.4 0.0 7.6e-20 71.7 0.0 1.4 1 0 0 1 1 1 1 Amino-transferase class IV 2-Hacid_dh_C PF02826.19 EXF76186.1 - 9.3e-43 145.6 0.0 3.5e-42 143.8 0.0 1.9 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EXF76186.1 - 1.4e-07 31.3 0.0 1.8e-07 30.9 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 EXF76186.1 - 1.7e-05 25.0 0.0 2.7e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 EXF76186.1 - 4e-05 24.1 0.0 7.8e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_Gly3P_dh_N PF01210.23 EXF76186.1 - 0.00043 20.3 0.0 0.00068 19.6 0.0 1.3 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus AlaDh_PNT_C PF01262.21 EXF76186.1 - 0.00061 19.2 0.0 0.00088 18.6 0.0 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain 3HCDH_N PF02737.18 EXF76186.1 - 0.0027 17.6 0.0 0.0048 16.8 0.0 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ApbA PF02558.16 EXF76186.1 - 0.0047 16.6 0.0 0.0063 16.2 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA XdhC_C PF13478.6 EXF76186.1 - 0.0052 17.3 0.0 0.0093 16.5 0.0 1.5 1 0 0 1 1 1 1 XdhC Rossmann domain Dr_adhesin PF12393.8 EXF76186.1 - 0.029 14.6 0.6 8.7 6.8 0.1 2.7 2 0 0 2 2 2 0 Dr family adhesin UDPG_MGDP_dh_N PF03721.14 EXF76186.1 - 0.043 13.4 0.0 0.11 12.1 0.0 1.7 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Pyr_redox PF00070.27 EXF76186.1 - 0.047 14.3 0.0 0.093 13.3 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.6 EXF76186.1 - 0.055 13.9 0.0 0.12 12.9 0.0 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding Pyr_redox_2 PF07992.14 EXF76186.1 - 0.075 12.3 0.0 0.12 11.6 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Sacchrp_dh_NADP PF03435.18 EXF76186.1 - 0.14 12.4 0.4 0.65 10.3 0.4 2.0 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain HU-CCDC81_bac_1 PF18174.1 EXF76186.1 - 0.14 12.0 0.2 0.39 10.6 0.0 1.8 2 0 0 2 2 2 0 CCDC81-like prokaryotic HU domain 1 TrkA_N PF02254.18 EXF76186.1 - 0.15 12.3 0.0 0.38 11.0 0.0 1.7 1 0 0 1 1 1 0 TrkA-N domain Peptidase_M1 PF01433.20 EXF76187.1 - 1.1e-36 126.5 0.6 1.8e-36 125.7 0.6 1.4 1 0 0 1 1 1 1 Peptidase family M1 domain Peptidase_M20 PF01546.28 EXF76187.1 - 3.2e-30 105.4 0.0 1.3e-29 103.4 0.0 1.9 2 0 0 2 2 2 1 Peptidase family M20/M25/M40 Leuk-A4-hydro_C PF09127.11 EXF76187.1 - 4.8e-29 100.7 0.0 1.1e-28 99.6 0.0 1.7 1 0 0 1 1 1 1 Leukotriene A4 hydrolase, C-terminal M20_dimer PF07687.14 EXF76187.1 - 2.6e-10 40.2 0.0 5.7e-10 39.1 0.0 1.6 1 0 0 1 1 1 1 Peptidase dimerisation domain Ephrin_rec_like PF07699.13 EXF76187.1 - 0.046 13.5 0.2 0.13 12.1 0.2 1.7 1 0 0 1 1 1 0 Putative ephrin-receptor like Peptidase_MA_2 PF13485.6 EXF76187.1 - 0.057 13.1 1.3 0.3 10.7 1.3 2.0 1 1 0 1 1 1 0 Peptidase MA superfamily WG_beta_rep PF14903.6 EXF76187.1 - 0.12 12.7 0.0 0.32 11.3 0.0 1.8 1 0 0 1 1 1 0 WG containing repeat Tyrosinase PF00264.20 EXF76188.1 - 8.3e-39 134.2 4.3 4.4e-38 131.8 3.7 2.2 1 1 0 1 1 1 1 Common central domain of tyrosinase adh_short PF00106.25 EXF76189.1 - 2.6e-09 36.8 0.2 4e-09 36.2 0.2 1.3 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF76189.1 - 6.2e-05 22.7 0.1 8.4e-05 22.2 0.1 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase F420_oxidored PF03807.17 EXF76189.1 - 0.02 15.4 0.0 0.038 14.6 0.0 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Abhydrolase_1 PF00561.20 EXF76190.1 - 3.6e-10 39.9 0.0 8.6e-07 28.8 0.0 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EXF76190.1 - 1.6e-06 28.9 0.3 0.00023 21.9 0.0 2.2 1 1 1 2 2 2 2 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EXF76190.1 - 0.0021 17.4 0.0 0.26 10.5 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 EHN PF06441.12 EXF76190.1 - 0.11 12.9 0.2 0.48 10.8 0.0 2.2 2 0 0 2 2 2 0 Epoxide hydrolase N terminus Cellulase PF00150.18 EXF76191.1 - 2.2e-13 50.3 0.1 3.1e-13 49.8 0.1 1.2 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) adh_short PF00106.25 EXF76192.1 - 4.4e-30 104.6 0.1 6e-30 104.2 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF76192.1 - 1.2e-20 74.1 0.1 1.6e-20 73.6 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF76192.1 - 1.3e-05 25.2 0.0 2.8e-05 24.1 0.0 1.5 1 1 0 1 1 1 1 KR domain 3HCDH_N PF02737.18 EXF76192.1 - 0.0086 16.0 0.0 0.016 15.1 0.0 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain MFS_1 PF07690.16 EXF76193.1 - 4e-37 128.0 19.1 4e-37 128.0 19.1 3.0 1 1 1 2 2 2 1 Major Facilitator Superfamily PGAP1 PF07819.13 EXF76193.1 - 2.6e-09 37.2 0.0 5.8e-09 36.0 0.0 1.5 1 0 0 1 1 1 1 PGAP1-like protein Sugar_tr PF00083.24 EXF76193.1 - 4.3e-08 32.5 5.5 7.2e-08 31.7 5.5 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter NACHT PF05729.12 EXF76193.1 - 2.8e-07 30.6 0.0 9.4e-07 28.9 0.0 1.9 1 0 0 1 1 1 1 NACHT domain ANAPC4_WD40 PF12894.7 EXF76193.1 - 9.3e-07 29.1 0.0 0.17 12.2 0.0 4.3 3 2 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Abhydrolase_6 PF12697.7 EXF76193.1 - 3.8e-05 24.4 0.2 3.8e-05 24.4 0.2 2.5 3 0 0 3 3 2 1 Alpha/beta hydrolase family TRI12 PF06609.13 EXF76193.1 - 8.2e-05 21.2 4.7 0.00013 20.5 4.7 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF676 PF05057.14 EXF76193.1 - 0.00086 18.9 0.0 0.0021 17.6 0.0 1.5 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_1 PF00561.20 EXF76193.1 - 0.0018 17.9 0.1 0.0045 16.7 0.1 1.6 1 0 0 1 1 1 1 alpha/beta hydrolase fold AAA_5 PF07728.14 EXF76193.1 - 0.028 14.4 0.0 0.09 12.8 0.0 1.8 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) Hydrolase_4 PF12146.8 EXF76193.1 - 0.046 13.0 0.0 0.11 11.8 0.0 1.5 1 0 0 1 1 1 0 Serine aminopeptidase, S33 AAA PF00004.29 EXF76193.1 - 0.096 13.1 0.1 0.55 10.7 0.0 2.4 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) LCAT PF02450.15 EXF76193.1 - 0.13 11.4 0.0 0.29 10.2 0.0 1.5 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase AAA_19 PF13245.6 EXF76193.1 - 0.14 12.5 0.0 0.33 11.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain TMEM154 PF15102.6 EXF76194.1 - 0.00035 20.5 2.9 0.00036 20.4 1.7 1.6 1 1 1 2 2 2 1 TMEM154 protein family Herpes_gE PF02480.16 EXF76194.1 - 0.0059 15.4 0.1 0.0082 14.9 0.1 1.1 1 0 0 1 1 1 1 Alphaherpesvirus glycoprotein E EphA2_TM PF14575.6 EXF76194.1 - 0.028 15.3 0.0 0.049 14.5 0.0 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain stn_TNFRSF12A PF12191.8 EXF76194.1 - 0.036 14.3 0.0 0.11 12.8 0.0 1.8 1 0 0 1 1 1 0 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain DAP10 PF07213.11 EXF76194.1 - 0.13 12.3 0.3 0.53 10.3 0.0 2.2 2 0 0 2 2 2 0 DAP10 membrane protein LapA_dom PF06305.11 EXF76194.1 - 0.21 11.4 0.0 0.4 10.5 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain DUF4834 PF16118.5 EXF76194.1 - 0.21 12.6 1.0 0.96 10.5 1.0 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) DUF2561 PF10812.8 EXF76194.1 - 0.29 11.1 0.0 0.29 11.1 0.0 1.8 2 1 0 2 2 2 0 Protein of unknown function (DUF2561) EamA PF00892.20 EXF76195.1 - 5.2e-10 39.6 25.8 3e-06 27.4 2.4 3.0 2 1 0 3 3 3 2 EamA-like transporter family Nuc_sug_transp PF04142.15 EXF76195.1 - 0.0029 16.8 2.3 0.013 14.7 2.3 1.9 1 1 0 1 1 1 1 Nucleotide-sugar transporter SLC35F PF06027.12 EXF76195.1 - 0.0033 17.0 1.2 0.0033 17.0 1.2 2.0 2 0 0 2 2 2 1 Solute carrier family 35 CSG2 PF16965.5 EXF76195.1 - 0.0045 16.0 19.1 0.008 15.2 4.9 3.3 2 1 1 3 3 3 2 Ceramide synthase regulator DUF5453 PF17534.2 EXF76195.1 - 0.14 12.1 0.2 0.31 11.0 0.2 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5453) DUF202 PF02656.15 EXF76195.1 - 0.28 11.6 13.6 0.17 12.3 0.8 4.5 4 1 0 4 4 4 0 Domain of unknown function (DUF202) DUF2723 PF11028.8 EXF76195.1 - 0.59 10.0 9.8 0.66 9.9 4.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2723) Aldo_ket_red PF00248.21 EXF76196.1 - 6.6e-53 179.8 0.0 7.6e-53 179.6 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family KilA-N PF04383.13 EXF76197.1 - 5.8e-08 32.6 0.2 5.9e-07 29.3 0.2 2.4 1 1 0 1 1 1 1 KilA-N domain Ank_2 PF12796.7 EXF76197.1 - 9.9e-08 32.5 0.0 1.9e-07 31.6 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 EXF76197.1 - 3.9e-06 27.1 0.1 0.001 19.4 0.0 2.7 2 0 0 2 2 2 1 Ankyrin repeat Ank_5 PF13857.6 EXF76197.1 - 7.1e-06 26.2 0.3 4.5e-05 23.6 0.1 2.3 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 EXF76197.1 - 1.4e-05 25.5 0.1 0.0011 19.5 0.1 2.6 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EXF76197.1 - 0.00046 20.4 0.0 0.056 14.0 0.0 2.8 2 0 0 2 2 2 1 Ankyrin repeat ALMT PF11744.8 EXF76197.1 - 1.9 7.2 3.9 3.3 6.4 3.9 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter adh_short PF00106.25 EXF76200.1 - 3.2e-37 127.9 0.0 4.3e-37 127.5 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF76200.1 - 3.3e-19 69.4 0.0 4.5e-19 68.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF76200.1 - 6.1e-11 42.5 0.1 1e-09 38.5 0.1 2.1 1 1 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 EXF76200.1 - 0.00012 22.1 0.1 0.00018 21.5 0.1 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EXF76200.1 - 0.00051 19.6 0.1 0.00095 18.7 0.1 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF1776 PF08643.10 EXF76200.1 - 0.0035 16.7 0.7 0.0047 16.3 0.7 1.1 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) ADH_zinc_N PF00107.26 EXF76200.1 - 0.01 15.8 0.0 0.015 15.2 0.0 1.2 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Sacchrp_dh_NADP PF03435.18 EXF76200.1 - 0.037 14.3 0.0 0.12 12.7 0.0 1.8 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain GDP_Man_Dehyd PF16363.5 EXF76200.1 - 0.15 11.4 0.0 0.23 10.8 0.0 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Uds1 PF15456.6 EXF76202.1 - 8.8e-05 22.7 0.7 0.00015 21.9 0.7 1.4 1 0 0 1 1 1 1 Up-regulated During Septation ALIX_LYPXL_bnd PF13949.6 EXF76202.1 - 0.0022 17.4 0.3 0.0027 17.1 0.3 1.2 1 0 0 1 1 1 1 ALIX V-shaped domain binding to HIV GOLGA2L5 PF15070.6 EXF76202.1 - 0.0051 15.5 2.8 0.0058 15.3 2.8 1.1 1 0 0 1 1 1 1 Putative golgin subfamily A member 2-like protein 5 SHE3 PF17078.5 EXF76202.1 - 0.0074 16.0 1.2 0.0093 15.7 1.2 1.2 1 0 0 1 1 1 1 SWI5-dependent HO expression protein 3 Cep57_MT_bd PF06657.13 EXF76202.1 - 0.012 16.0 0.5 0.02 15.4 0.5 1.3 1 0 0 1 1 1 0 Centrosome microtubule-binding domain of Cep57 Trimer_CC PF08954.11 EXF76202.1 - 0.012 15.1 0.5 1.4 8.5 1.0 2.6 2 0 0 2 2 2 0 Trimerisation motif Bap31_Bap29_C PF18035.1 EXF76202.1 - 0.16 12.0 7.0 3.7 7.6 1.3 2.3 2 0 0 2 2 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain SbsC_C PF18058.1 EXF76202.1 - 0.44 10.8 5.1 1.9 8.7 2.4 2.0 1 1 1 2 2 2 0 SbsC C-terminal domain Phage_GP20 PF06810.11 EXF76202.1 - 0.69 9.7 6.8 6.1 6.6 3.2 2.0 1 1 0 2 2 2 0 Phage minor structural protein GP20 60KD_IMP PF02096.20 EXF76202.1 - 1.1 9.1 4.5 2.4 8.0 3.6 1.8 1 1 1 2 2 2 0 60Kd inner membrane protein Pro_Al_protease PF02983.14 EXF76204.1 - 2.6e-13 49.8 2.7 2.6e-13 49.8 2.7 1.9 2 0 0 2 2 2 1 Alpha-lytic protease prodomain Trypsin PF00089.26 EXF76204.1 - 5.6e-05 23.1 10.1 0.00018 21.4 10.1 1.7 1 1 0 1 1 1 1 Trypsin Cu-oxidase_3 PF07732.15 EXF76206.1 - 7.1e-41 139.0 2.7 2.6e-40 137.1 0.3 2.9 4 0 0 4 4 4 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 EXF76206.1 - 1.8e-31 108.7 6.5 1.6e-28 99.1 0.4 3.7 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.22 EXF76206.1 - 3e-17 63.2 0.0 1.5e-15 57.7 0.0 2.9 2 1 0 2 2 2 1 Multicopper oxidase Cupredoxin_1 PF13473.6 EXF76206.1 - 0.036 14.2 0.0 0.12 12.5 0.0 1.9 1 1 0 1 1 1 0 Cupredoxin-like domain SGL PF08450.12 EXF76207.1 - 0.0016 18.1 0.0 0.0022 17.6 0.0 1.5 1 1 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region FMO-like PF00743.19 EXF76208.1 - 2.5e-89 300.1 0.0 3.1e-89 299.8 0.0 1.0 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EXF76208.1 - 1e-13 51.2 0.0 9.1e-12 44.8 0.0 2.4 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EXF76208.1 - 4.6e-13 49.1 0.0 1.4e-09 37.6 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EXF76208.1 - 2e-11 43.6 0.1 9.9e-08 31.5 0.0 3.1 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 EXF76208.1 - 8.9e-07 29.0 0.1 0.02 14.9 0.0 3.3 3 0 0 3 3 3 2 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 EXF76208.1 - 2.8e-06 27.5 0.0 6.7e-06 26.2 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 EXF76208.1 - 0.00012 22.6 0.1 0.66 10.6 0.0 2.6 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EXF76208.1 - 0.00086 18.1 0.9 0.0017 17.1 0.3 1.7 2 0 0 2 2 2 1 HI0933-like protein DAO PF01266.24 EXF76208.1 - 0.0011 18.7 2.7 1.6 8.3 0.0 3.3 3 1 0 3 3 3 2 FAD dependent oxidoreductase Thi4 PF01946.17 EXF76208.1 - 0.0038 16.5 0.3 0.015 14.6 0.1 1.9 2 0 0 2 2 2 1 Thi4 family FAD_binding_2 PF00890.24 EXF76208.1 - 0.013 14.6 0.0 0.018 14.2 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain GIDA PF01134.22 EXF76208.1 - 0.014 14.5 0.0 4.1 6.4 0.0 2.7 3 0 0 3 3 3 0 Glucose inhibited division protein A FAD_oxidored PF12831.7 EXF76208.1 - 0.038 13.3 0.1 0.057 12.8 0.1 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase Shikimate_DH PF01488.20 EXF76208.1 - 0.091 12.8 0.0 20 5.2 0.0 2.5 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase FAD_binding_3 PF01494.19 EXF76208.1 - 0.1 11.8 0.3 0.22 10.7 0.1 1.6 2 0 0 2 2 2 0 FAD binding domain AlaDh_PNT_C PF01262.21 EXF76208.1 - 0.16 11.2 0.3 0.48 9.7 0.1 1.8 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain adh_short PF00106.25 EXF76209.1 - 1.6e-16 60.3 0.1 2.2e-11 43.6 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EXF76209.1 - 8.3e-10 38.6 0.2 1.7e-06 27.8 0.1 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 EXF76209.1 - 0.00032 20.2 0.0 0.00042 19.9 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family KR PF08659.10 EXF76209.1 - 0.097 12.6 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 KR domain Zn_clus PF00172.18 EXF76210.1 - 1.9e-08 34.3 8.5 4.6e-08 33.1 8.5 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EXF76210.1 - 2.6e-06 26.5 0.3 4.2e-06 25.8 0.3 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Melibiase PF02065.18 EXF76211.1 - 1.2e-147 491.5 0.0 1.4e-147 491.2 0.0 1.1 1 0 0 1 1 1 1 Melibiase Glyco_hydro_36N PF16875.5 EXF76211.1 - 2e-80 270.0 0.0 3.1e-80 269.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 36 N-terminal domain Glyco_hydro_36C PF16874.5 EXF76211.1 - 3.7e-23 81.8 0.1 7.3e-23 80.9 0.1 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 36 C-terminal domain GHL10 PF02638.15 EXF76211.1 - 0.00081 18.6 0.0 0.0013 17.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase-like 10 FAD_binding_3 PF01494.19 EXF76212.1 - 3.5e-23 82.4 0.0 6.9e-23 81.5 0.0 1.3 1 1 0 1 1 1 1 FAD binding domain Lycopene_cycl PF05834.12 EXF76212.1 - 0.00072 18.7 0.1 0.52 9.3 0.1 2.7 3 0 0 3 3 3 2 Lycopene cyclase protein Amino_oxidase PF01593.24 EXF76212.1 - 0.0023 17.3 0.0 0.28 10.4 0.0 2.4 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase Pyr_redox_2 PF07992.14 EXF76212.1 - 0.0062 15.8 0.3 0.051 12.8 0.1 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EXF76212.1 - 0.022 14.4 0.0 0.086 12.4 0.0 1.8 1 1 1 2 2 2 0 FAD dependent oxidoreductase Pyr_redox PF00070.27 EXF76212.1 - 0.024 15.2 0.9 0.055 14.0 0.1 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EXF76212.1 - 0.065 12.5 0.8 0.41 9.8 0.2 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EXF76212.1 - 0.085 11.7 0.0 8.4 5.1 0.0 2.8 3 0 0 3 3 3 0 Tryptophan halogenase Aminotran_1_2 PF00155.21 EXF76213.1 - 3e-37 128.7 0.0 4e-37 128.3 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 EXF76213.1 - 0.066 12.5 0.0 0.23 10.7 0.0 1.7 1 1 0 1 1 1 0 Beta-eliminating lyase DinB PF05163.12 EXF76214.1 - 3.9e-19 69.2 0.3 4.4e-19 69.0 0.3 1.1 1 0 0 1 1 1 1 DinB family DinB_2 PF12867.7 EXF76214.1 - 3.7e-06 27.5 0.2 4.3e-06 27.3 0.2 1.1 1 0 0 1 1 1 1 DinB superfamily Aminotran_4 PF01063.19 EXF76216.1 - 5.9e-24 85.2 0.0 8.1e-24 84.7 0.0 1.2 1 0 0 1 1 1 1 Amino-transferase class IV CTP_transf_like PF01467.26 EXF76217.1 - 4.6e-19 69.0 0.0 3.9e-14 53.1 0.1 3.4 3 1 0 3 3 3 3 Cytidylyltransferase-like His_Phos_1 PF00300.22 EXF76218.1 - 9.3e-07 28.7 0.0 4.2e-06 26.6 0.0 2.0 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) WD40 PF00400.32 EXF76220.1 - 7.6e-16 58.2 9.6 0.0097 16.7 0.1 5.4 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EXF76220.1 - 8.8e-06 25.9 0.0 0.013 15.8 0.0 3.9 1 1 4 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EXF76220.1 - 0.00073 18.9 0.0 0.0014 18.1 0.0 1.4 1 0 0 1 1 1 1 WD40-like domain FliO PF04347.13 EXF76220.1 - 0.13 12.6 0.0 0.23 11.8 0.0 1.4 1 0 0 1 1 1 0 Flagellar biosynthesis protein, FliO FMO-like PF00743.19 EXF76222.1 - 6.9e-14 51.2 0.1 2.4e-13 49.4 0.0 1.9 2 1 0 2 2 2 1 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 EXF76222.1 - 2.8e-08 33.4 0.0 3.8e-06 26.3 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EXF76222.1 - 1.1e-07 32.0 0.1 7.1e-07 29.4 0.0 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 EXF76222.1 - 1e-06 28.3 0.0 2e-06 27.3 0.0 1.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EXF76222.1 - 3.9e-06 26.7 2.1 0.015 14.9 0.2 3.6 2 1 1 4 4 4 2 FAD dependent oxidoreductase Thi4 PF01946.17 EXF76222.1 - 4.8e-06 26.0 0.0 0.00031 20.0 0.0 2.2 2 0 0 2 2 2 1 Thi4 family Mqo PF06039.15 EXF76222.1 - 0.007 15.0 0.0 0.14 10.7 0.0 2.3 2 0 0 2 2 2 1 Malate:quinone oxidoreductase (Mqo) GIDA PF01134.22 EXF76222.1 - 0.062 12.4 0.9 2.6 7.0 0.1 2.1 2 0 0 2 2 2 0 Glucose inhibited division protein A Amino_oxidase PF01593.24 EXF76222.1 - 0.2 10.9 0.1 0.59 9.3 0.0 1.9 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase PKHD_C PF18331.1 EXF76223.1 - 0.0038 17.3 0.1 5.1 7.2 0.0 2.8 2 0 0 2 2 2 2 PKHD-type hydroxylase C-terminal domain RDM PF11002.8 EXF76223.1 - 0.0053 16.7 3.2 68 3.6 0.0 5.0 5 0 0 5 5 5 0 RFPL defining motif (RDM) Wzz PF02706.15 EXF76223.1 - 0.11 12.8 2.2 1.1 9.6 0.1 2.8 1 1 1 2 2 2 0 Chain length determinant protein Erythro-docking PF09277.11 EXF76223.1 - 0.18 11.7 6.0 2.6 8.0 1.1 2.3 2 0 0 2 2 2 0 Erythronolide synthase, docking Gallidermin PF02052.15 EXF76223.1 - 3.3 8.1 10.9 3.1 8.2 0.5 3.4 2 1 2 4 4 4 0 Gallidermin Abhydrolase_1 PF00561.20 EXF76224.1 - 1.1e-18 67.8 0.1 1.4e-13 51.1 0.1 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EXF76224.1 - 2.6e-10 40.0 0.0 1.4e-05 24.5 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EXF76224.1 - 7.4e-09 36.5 0.0 1e-08 36.1 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family DLH PF01738.18 EXF76224.1 - 0.00011 21.9 0.2 0.0088 15.6 0.0 2.1 2 0 0 2 2 2 1 Dienelactone hydrolase family FSH1 PF03959.13 EXF76224.1 - 0.0012 18.6 0.0 0.0077 15.9 0.0 2.0 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_4 PF08386.10 EXF76224.1 - 0.0052 16.9 0.0 0.0093 16.1 0.0 1.4 1 0 0 1 1 1 1 TAP-like protein BAAT_C PF08840.11 EXF76224.1 - 0.062 13.2 0.1 0.59 10.0 0.0 2.0 2 0 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal Esterase PF00756.20 EXF76224.1 - 0.14 11.8 0.0 0.19 11.3 0.0 1.3 1 0 0 1 1 1 0 Putative esterase ADH_N PF08240.12 EXF76225.1 - 2.1e-17 63.0 2.2 3.1e-16 59.2 0.1 2.9 2 2 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EXF76225.1 - 1e-15 57.8 2.9 1e-15 57.8 2.9 2.2 3 1 0 3 3 3 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EXF76225.1 - 6.7e-06 25.7 2.4 1.1e-05 25.1 2.4 1.2 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 EXF76225.1 - 0.0003 21.8 1.1 0.00043 21.4 0.3 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 EXF76225.1 - 0.00069 19.0 1.6 0.00069 19.0 1.6 2.0 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.19 EXF76225.1 - 0.00087 18.7 0.7 0.0017 17.8 0.1 1.7 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DUF5441 PF17513.2 EXF76225.1 - 0.002 17.9 2.2 0.003 17.3 2.2 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5441) NAD_binding_2 PF03446.15 EXF76225.1 - 0.0048 17.1 2.0 0.16 12.1 0.3 2.3 1 1 1 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase UDPG_MGDP_dh_N PF03721.14 EXF76225.1 - 0.025 14.2 0.1 0.046 13.3 0.1 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Ribosom_S12_S23 PF00164.25 EXF76225.1 - 0.054 13.1 0.2 0.46 10.1 0.0 2.5 2 1 1 3 3 3 0 Ribosomal protein S12/S23 Methyltransf_2 PF00891.18 EXF76227.1 - 6.2e-20 71.4 0.0 1.1e-19 70.6 0.0 1.4 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_31 PF13847.6 EXF76227.1 - 0.063 13.1 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain HTH_Tnp_ISL3 PF13542.6 EXF76227.1 - 0.16 11.4 0.0 0.54 9.7 0.0 2.0 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 p450 PF00067.22 EXF76228.1 - 5.5e-44 150.7 0.0 8.6e-44 150.0 0.0 1.2 1 1 0 1 1 1 1 Cytochrome P450 Gly_transf_sug PF04488.15 EXF76229.1 - 2.1e-09 37.9 0.2 3.8e-09 37.0 0.2 1.3 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif TcdA_TcdB PF12919.7 EXF76229.1 - 0.028 13.7 0.4 0.12 11.7 0.0 2.0 2 0 0 2 2 2 0 TcdA/TcdB catalytic glycosyltransferase domain Caps_synth PF05704.12 EXF76229.1 - 0.062 12.7 0.0 0.085 12.2 0.0 1.2 1 0 0 1 1 1 0 Capsular polysaccharide synthesis protein Pantoate_ligase PF02569.15 EXF76229.1 - 0.14 11.4 0.0 0.2 10.8 0.0 1.2 1 0 0 1 1 1 0 Pantoate-beta-alanine ligase PS_Dcarbxylase PF02666.15 EXF76230.1 - 9.2e-48 162.4 0.0 1.2e-47 162.0 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase MFS_1 PF07690.16 EXF76231.1 - 6.2e-29 101.0 37.2 1.4e-28 99.9 26.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF76231.1 - 1.1e-13 50.8 7.6 2.6e-13 49.7 7.6 1.6 1 0 0 1 1 1 1 Sugar (and other) transporter AAA PF00004.29 EXF76232.1 - 2e-15 57.4 0.0 4.1e-15 56.4 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EXF76232.1 - 2.2e-05 24.9 1.1 0.00041 20.8 1.0 2.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EXF76232.1 - 3.6e-05 24.1 0.6 0.0027 18.0 0.1 2.5 1 1 1 2 2 2 1 AAA domain AAA_5 PF07728.14 EXF76232.1 - 0.029 14.4 0.0 0.09 12.8 0.0 1.8 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 EXF76232.1 - 0.12 12.5 0.0 0.23 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) AAA_24 PF13479.6 EXF76232.1 - 0.12 12.1 0.0 0.23 11.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain HMG-CoA_red PF00368.18 EXF76233.1 - 1e-140 469.0 4.6 1.3e-140 468.6 4.6 1.2 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase HPIH PF13323.6 EXF76233.1 - 2.7e-51 173.5 2.0 4.6e-51 172.8 2.0 1.4 1 0 0 1 1 1 1 N-terminal domain with HPIH motif Sterol-sensing PF12349.8 EXF76233.1 - 9.7e-13 48.2 4.7 4.1e-11 42.9 4.7 2.6 1 1 0 1 1 1 1 Sterol-sensing domain of SREBP cleavage-activation Patched PF02460.18 EXF76233.1 - 3.3e-05 22.2 0.9 5.6e-05 21.4 0.9 1.3 1 0 0 1 1 1 1 Patched family Lig_chan PF00060.26 EXF76233.1 - 0.016 15.1 2.1 2.2 8.1 0.0 2.5 2 0 0 2 2 2 0 Ligand-gated ion channel Isochorismatase PF00857.20 EXF76234.1 - 1.9e-24 86.8 0.1 3.1e-24 86.1 0.1 1.4 1 1 0 1 1 1 1 Isochorismatase family S1-P1_nuclease PF02265.16 EXF76235.1 - 5.1e-63 213.2 0.0 5.8e-63 213.1 0.0 1.0 1 0 0 1 1 1 1 S1/P1 Nuclease ECH_1 PF00378.20 EXF76236.1 - 9e-45 152.9 0.0 1.2e-44 152.5 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EXF76236.1 - 7.4e-25 88.1 0.0 2.5e-24 86.4 0.0 1.7 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase NAD_binding_8 PF13450.6 EXF76237.1 - 4.7e-13 49.1 0.1 1.2e-12 47.9 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EXF76237.1 - 1.1e-08 35.1 0.3 8.3e-07 28.9 0.0 2.5 2 1 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EXF76237.1 - 1.5e-06 27.7 0.1 0.00018 20.8 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 EXF76237.1 - 3e-06 26.8 0.1 0.23 10.7 0.0 3.3 3 0 0 3 3 3 2 Flavin containing amine oxidoreductase Pyr_redox PF00070.27 EXF76237.1 - 0.00015 22.3 0.1 0.58 10.8 0.0 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EXF76237.1 - 0.00041 19.6 0.0 0.00068 18.8 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 EXF76237.1 - 0.00041 19.2 0.1 0.025 13.3 0.0 2.1 2 0 0 2 2 2 1 HI0933-like protein NAD_binding_9 PF13454.6 EXF76237.1 - 0.0013 18.8 0.0 0.0066 16.4 0.0 2.1 2 0 0 2 2 2 1 FAD-NAD(P)-binding Thi4 PF01946.17 EXF76237.1 - 0.0049 16.2 0.0 0.0087 15.3 0.0 1.3 1 0 0 1 1 1 1 Thi4 family FAD_oxidored PF12831.7 EXF76237.1 - 0.084 12.2 0.2 0.24 10.7 0.0 1.9 3 0 0 3 3 3 0 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 EXF76237.1 - 0.09 11.8 0.0 0.15 11.1 0.0 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein zf-C2H2_2 PF12756.7 EXF76238.1 - 3.4e-23 81.9 0.3 7e-23 80.9 0.3 1.4 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) adh_short PF00106.25 EXF76241.1 - 9.8e-17 61.1 0.1 7.1e-08 32.1 0.0 2.5 2 1 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EXF76241.1 - 1.7e-11 44.1 0.1 5.5e-07 29.4 0.0 2.2 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase OmdA PF13376.6 EXF76242.1 - 4.3e-09 36.2 0.5 1.5e-08 34.5 0.2 2.1 2 0 0 2 2 2 1 Bacteriocin-protection, YdeI or OmpD-Associated Lipase_GDSL_2 PF13472.6 EXF76244.1 - 3.5e-20 73.1 1.7 5.9e-20 72.4 1.7 1.4 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EXF76244.1 - 0.0012 18.8 0.1 0.0039 17.2 0.1 1.9 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase DUF2207 PF09972.9 EXF76245.1 - 9.1 4.9 5.5 4.9 5.8 4.0 1.3 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) WD40 PF00400.32 EXF76246.1 - 3.4e-06 27.7 15.1 0.00026 21.7 1.2 5.6 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EXF76246.1 - 0.0026 18.0 0.1 0.5 10.7 0.1 3.4 2 2 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Zn_Tnp_IS1595 PF12760.7 EXF76246.1 - 0.011 15.6 1.4 0.011 15.6 1.4 2.4 4 0 0 4 4 4 0 Transposase zinc-ribbon domain zinc_ribbon_4 PF13717.6 EXF76246.1 - 0.22 11.5 3.6 0.82 9.6 3.6 2.0 1 1 0 1 1 1 0 zinc-ribbon domain Zn_ribbon_17 PF17120.5 EXF76246.1 - 5.1 6.8 17.9 0.099 12.3 9.7 2.2 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type Atg14 PF10186.9 EXF76247.1 - 7.4e-18 64.7 0.0 1.4e-17 63.7 0.0 1.4 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 VPS38 PF17649.1 EXF76247.1 - 1.2e-12 47.5 1.4 1.9e-07 30.3 0.1 3.5 3 1 0 3 3 3 3 Vacuolar protein sorting 38 DUF4522 PF15022.6 EXF76247.1 - 0.058 13.7 0.6 0.12 12.6 0.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4522) Snapin_Pallidin PF14712.6 EXF76247.1 - 8.7 6.8 11.2 5.9 7.4 2.0 2.8 1 1 1 2 2 2 0 Snapin/Pallidin adh_short PF00106.25 EXF76251.1 - 9.2e-27 93.8 0.0 1e-23 83.8 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EXF76251.1 - 4.6e-15 55.8 0.0 1.2e-14 54.4 0.0 1.6 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF76251.1 - 1.8e-08 34.5 0.1 3.3e-08 33.7 0.1 1.4 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EXF76251.1 - 0.00032 20.2 0.0 0.00064 19.3 0.0 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EXF76251.1 - 0.0028 17.1 0.0 0.0036 16.7 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase ADH_zinc_N PF00107.26 EXF76251.1 - 0.0039 17.2 0.0 0.017 15.1 0.0 2.1 3 0 0 3 3 3 1 Zinc-binding dehydrogenase Fungal_trans_2 PF11951.8 EXF76252.1 - 0.0064 15.3 0.2 0.0092 14.8 0.2 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain FAD_binding_4 PF01565.23 EXF76253.1 - 3.8e-27 94.7 6.7 1.1e-26 93.2 6.7 1.9 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EXF76253.1 - 3e-13 49.7 0.4 5.4e-13 48.8 0.4 1.5 1 0 0 1 1 1 1 Berberine and berberine like Cupin_1 PF00190.22 EXF76254.1 - 4.1e-20 71.9 0.3 5.7e-20 71.5 0.3 1.1 1 0 0 1 1 1 1 Cupin Cupin_2 PF07883.11 EXF76254.1 - 2.4e-08 33.6 0.0 4.7e-08 32.6 0.0 1.5 1 0 0 1 1 1 1 Cupin domain Cupin_6 PF12852.7 EXF76254.1 - 0.016 14.9 0.0 0.021 14.5 0.0 1.3 1 0 0 1 1 1 0 Cupin Tyrosinase PF00264.20 EXF76255.1 - 8.6e-44 150.4 1.1 1.4e-43 149.8 1.1 1.3 1 0 0 1 1 1 1 Common central domain of tyrosinase Transferase PF02458.15 EXF76256.1 - 2.3e-24 85.9 0.0 5.7e-24 84.6 0.0 1.5 2 0 0 2 2 2 1 Transferase family Spc7 PF08317.11 EXF76257.1 - 0.009 14.9 7.5 0.012 14.5 7.5 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein MFS_1 PF07690.16 EXF76258.1 - 2.3e-26 92.5 36.8 6.9e-23 81.1 21.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF1479 PF07350.12 EXF76259.1 - 0.0037 16.1 0.0 0.0055 15.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1479) MFS_1 PF07690.16 EXF76260.1 - 5.2e-31 107.8 35.5 5.2e-31 107.8 35.5 1.5 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 EXF76260.1 - 0.00043 19.7 9.4 0.00043 19.7 9.4 1.9 1 1 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB NmrA PF05368.13 EXF76261.1 - 2.1e-09 37.3 0.0 9.6e-09 35.1 0.0 1.8 1 1 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EXF76261.1 - 3.2e-07 30.4 0.0 4.5e-07 29.9 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding MFS_1 PF07690.16 EXF76262.1 - 4.7e-21 75.1 51.1 4.7e-21 75.1 51.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily EthD PF07110.11 EXF76263.1 - 0.08 14.1 0.0 0.09 13.9 0.0 1.1 1 0 0 1 1 1 0 EthD domain DJ-1_PfpI PF01965.24 EXF76264.1 - 2.9e-06 27.2 0.0 5.3e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 DJ-1/PfpI family Fungal_trans_2 PF11951.8 EXF76264.1 - 0.00044 19.2 1.8 0.0021 17.0 0.7 2.1 2 0 0 2 2 2 1 Fungal specific transcription factor domain ThiJ_like PF17124.5 EXF76264.1 - 0.02 14.6 0.0 0.094 12.4 0.0 2.2 3 0 0 3 3 3 0 ThiJ/PfpI family-like Imm3 PF14425.6 EXF76264.1 - 0.022 14.8 0.0 0.047 13.7 0.0 1.5 1 0 0 1 1 1 0 Immunity protein Imm3 Epimerase PF01370.21 EXF76265.1 - 1.1e-16 61.0 0.0 1.8e-16 60.4 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EXF76265.1 - 9.5e-12 44.5 0.0 1.5e-11 43.8 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 EXF76265.1 - 3.8e-11 42.7 0.0 2.1e-09 36.9 0.0 2.1 1 1 0 1 1 1 1 Male sterility protein GDP_Man_Dehyd PF16363.5 EXF76265.1 - 2.2e-08 33.9 0.1 5.1e-08 32.7 0.1 1.7 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 EXF76265.1 - 3.8e-07 29.5 0.0 5e-07 29.1 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.6 EXF76265.1 - 8.4e-07 29.1 0.0 3.5e-06 27.0 0.1 1.9 2 0 0 2 2 2 1 NAD(P)H-binding NmrA PF05368.13 EXF76265.1 - 0.0002 21.0 0.1 0.00037 20.1 0.1 1.5 1 0 0 1 1 1 1 NmrA-like family KR PF08659.10 EXF76265.1 - 0.0047 16.8 0.2 0.0098 15.8 0.2 1.6 1 1 0 1 1 1 1 KR domain adh_short PF00106.25 EXF76265.1 - 0.026 14.0 0.3 0.36 10.2 0.1 2.4 2 0 0 2 2 2 0 short chain dehydrogenase NmrA PF05368.13 EXF76266.1 - 6.8e-05 22.5 0.0 9.7e-05 22.0 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family Sacchrp_dh_NADP PF03435.18 EXF76266.1 - 8.7e-05 22.8 0.0 0.00018 21.8 0.0 1.5 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_10 PF13460.6 EXF76266.1 - 0.0081 16.1 0.0 0.013 15.4 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding OpuAC PF04069.12 EXF76268.1 - 0.02 14.5 0.0 0.032 13.8 0.0 1.3 1 0 0 1 1 1 0 Substrate binding domain of ABC-type glycine betaine transport system SnoaL_2 PF12680.7 EXF76269.1 - 0.00054 20.6 0.0 0.00094 19.8 0.0 1.4 1 0 0 1 1 1 1 SnoaL-like domain DUF2358 PF10184.9 EXF76269.1 - 0.034 14.4 0.0 0.057 13.7 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2358) zf-RING_2 PF13639.6 EXF76270.1 - 1.2e-07 31.9 7.7 1.2e-07 31.9 7.7 2.3 2 0 0 2 2 2 1 Ring finger domain FANCL_C PF11793.8 EXF76270.1 - 1.2e-06 28.6 10.8 2.9e-06 27.3 7.1 2.3 2 0 0 2 2 2 1 FANCL C-terminal domain zf-ANAPC11 PF12861.7 EXF76270.1 - 0.013 15.5 6.1 0.013 15.5 6.1 2.0 1 1 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_1 PF14446.6 EXF76270.1 - 0.014 15.3 4.8 0.014 15.3 4.8 2.9 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 zf-rbx1 PF12678.7 EXF76270.1 - 0.029 14.7 5.9 0.029 14.7 5.9 2.0 2 0 0 2 2 2 0 RING-H2 zinc finger domain DUF1751 PF08551.10 EXF76271.1 - 9.3e-27 93.5 4.2 2.2e-26 92.3 4.2 1.6 1 0 0 1 1 1 1 Eukaryotic integral membrane protein (DUF1751) Rhomboid PF01694.22 EXF76271.1 - 0.51 10.3 8.6 1.1 9.2 8.6 1.5 1 1 0 1 1 1 0 Rhomboid family WD40 PF00400.32 EXF76272.1 - 4.4e-07 30.5 3.0 0.55 11.2 0.0 5.9 6 0 0 6 6 6 2 WD domain, G-beta repeat LisH PF08513.11 EXF76272.1 - 7.5e-07 28.9 0.1 1.7e-06 27.7 0.1 1.7 1 0 0 1 1 1 1 LisH ANAPC4_WD40 PF12894.7 EXF76272.1 - 1.8e-05 25.0 0.2 0.13 12.6 0.0 4.6 3 3 1 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain RRM_1 PF00076.22 EXF76273.1 - 8.9e-32 108.7 0.0 2.7e-15 56.0 0.0 3.3 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EXF76273.1 - 0.00013 22.0 0.0 0.14 12.3 0.0 2.8 2 1 1 3 3 3 2 RNA recognition motif RRM_5 PF13893.6 EXF76273.1 - 0.00017 21.2 0.0 0.3 10.7 0.0 3.1 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Tristanin_u2 PF16638.5 EXF76273.1 - 0.0052 17.6 5.2 0.0052 17.6 5.2 2.9 2 0 0 2 2 2 1 Unstructured region on methyltransferase between zinc-fingers PHM7_cyt PF14703.6 EXF76273.1 - 0.027 14.7 0.1 10 6.3 0.0 3.2 3 0 0 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter DbpA PF03880.15 EXF76273.1 - 0.051 13.6 0.3 10 6.2 0.0 2.9 3 0 0 3 3 3 0 DbpA RNA binding domain DUF4783 PF16022.5 EXF76273.1 - 0.077 13.2 0.0 0.93 9.7 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4783) Limkain-b1 PF11608.8 EXF76273.1 - 0.11 12.6 0.1 20 5.3 0.0 2.8 3 0 0 3 3 3 0 Limkain b1 DUF4944 PF16302.5 EXF76273.1 - 0.17 11.9 0.0 19 5.3 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4944) ETF PF01012.21 EXF76274.1 - 7.9e-45 153.0 0.8 1.3e-44 152.2 0.8 1.4 1 0 0 1 1 1 1 Electron transfer flavoprotein domain ArfGap PF01412.18 EXF76274.1 - 9e-32 109.6 0.3 1.7e-31 108.7 0.3 1.4 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf PEP_mutase PF13714.6 EXF76275.1 - 6.7e-50 169.8 1.2 7.8e-50 169.6 1.2 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase ICL PF00463.21 EXF76275.1 - 3.6e-20 71.9 1.1 4.6e-20 71.6 1.1 1.1 1 0 0 1 1 1 1 Isocitrate lyase family MR_MLE_C PF13378.6 EXF76275.1 - 0.003 17.2 0.5 0.0078 15.8 0.4 1.8 1 1 1 2 2 2 1 Enolase C-terminal domain-like S-methyl_trans PF02574.16 EXF76275.1 - 0.049 13.4 0.1 0.078 12.8 0.1 1.3 1 0 0 1 1 1 0 Homocysteine S-methyltransferase DUF575 PF04746.12 EXF76275.1 - 0.14 12.4 0.0 0.25 11.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF575) MFS_1 PF07690.16 EXF76276.1 - 1.4e-23 83.4 24.2 6.5e-23 81.2 24.2 1.8 1 1 0 1 1 1 1 Major Facilitator Superfamily Rad51 PF08423.11 EXF76276.1 - 0.051 12.8 0.0 0.09 12.0 0.0 1.3 1 0 0 1 1 1 0 Rad51 GATase PF00117.28 EXF76277.1 - 1.5e-47 161.9 0.0 1.9e-47 161.5 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I CPSase_sm_chain PF00988.22 EXF76277.1 - 2.4e-46 156.7 0.0 3.6e-46 156.1 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain Peptidase_C26 PF07722.13 EXF76277.1 - 5.1e-05 23.1 0.3 0.0046 16.7 0.3 2.7 1 1 0 1 1 1 1 Peptidase C26 KTI12 PF08433.10 EXF76278.1 - 0.044 13.2 0.0 0.065 12.7 0.0 1.2 1 0 0 1 1 1 0 Chromatin associated protein KTI12 PRK PF00485.18 EXF76278.1 - 0.092 12.5 0.0 0.19 11.5 0.0 1.5 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family MeaB PF03308.16 EXF76278.1 - 0.19 10.7 0.0 0.29 10.1 0.0 1.1 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Zeta_toxin PF06414.12 EXF76278.1 - 0.21 10.9 0.0 0.34 10.1 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin SAP PF02037.27 EXF76279.1 - 2.8e-12 46.1 0.5 5.9e-12 45.1 0.5 1.6 1 0 0 1 1 1 1 SAP domain GATA PF00320.27 EXF76281.1 - 1.3e-29 101.5 17.9 1.7e-15 56.3 3.0 2.7 2 0 0 2 2 2 2 GATA zinc finger TF_Zn_Ribbon PF08271.12 EXF76281.1 - 3.2e-06 26.6 4.8 0.0052 16.3 0.4 2.5 2 0 0 2 2 2 2 TFIIB zinc-binding ArfGap PF01412.18 EXF76281.1 - 0.00056 20.0 1.9 0.49 10.5 0.3 2.3 2 0 0 2 2 2 2 Putative GTPase activating protein for Arf Auto_anti-p27 PF06677.12 EXF76281.1 - 0.002 18.3 6.2 0.14 12.3 0.9 2.6 2 0 0 2 2 2 2 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) Zn-ribbon_8 PF09723.10 EXF76281.1 - 0.0052 16.9 9.3 0.086 13.0 0.1 2.8 3 0 0 3 3 2 2 Zinc ribbon domain OrfB_Zn_ribbon PF07282.11 EXF76281.1 - 0.019 14.9 2.1 0.019 14.9 2.1 2.8 3 0 0 3 3 3 0 Putative transposase DNA-binding domain zf-RRN7 PF11781.8 EXF76281.1 - 0.038 13.7 9.4 0.088 12.5 0.5 2.9 2 1 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 eIF-5_eIF-2B PF01873.17 EXF76281.1 - 0.11 12.4 4.8 2.9 7.8 0.3 2.4 2 0 0 2 2 2 0 Domain found in IF2B/IF5 NMD3 PF04981.13 EXF76281.1 - 0.35 10.3 1.7 6 6.3 0.1 2.2 2 0 0 2 2 2 0 NMD3 family DZR PF12773.7 EXF76281.1 - 0.42 10.7 13.1 0.52 10.4 0.4 3.0 2 1 1 3 3 3 0 Double zinc ribbon zf-Sec23_Sec24 PF04810.15 EXF76281.1 - 2.4 8.3 14.3 0.072 13.2 0.8 3.1 3 0 0 3 3 3 0 Sec23/Sec24 zinc finger Rubredoxin_2 PF18073.1 EXF76281.1 - 7.5 6.4 10.1 30 4.4 0.1 4.4 4 0 0 4 4 4 0 Rubredoxin metal binding domain zinc_ribbon_4 PF13717.6 EXF76281.1 - 7.6 6.6 6.4 3.4 7.7 0.1 3.0 3 0 0 3 3 3 0 zinc-ribbon domain COPI_assoc PF08507.10 EXF76282.1 - 4.6e-35 120.5 6.3 5.2e-35 120.3 6.3 1.0 1 0 0 1 1 1 1 COPI associated protein UCR_Fe-S_N PF10399.9 EXF76282.1 - 0.031 13.6 0.1 0.031 13.6 0.1 1.7 2 0 0 2 2 2 0 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal Cg6151-P PF10233.9 EXF76282.1 - 0.32 11.3 9.6 0.58 10.5 9.6 1.4 1 1 0 1 1 1 0 Uncharacterized conserved protein CG6151-P DUF2583 PF10762.9 EXF76282.1 - 0.55 10.7 3.4 4 7.9 0.2 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF2583) TMEM72 PF16054.5 EXF76282.1 - 0.57 9.8 5.8 1.2 8.8 1.9 2.0 2 0 0 2 2 2 0 Transmembrane protein family 72 Cytochrom_B558a PF05038.13 EXF76282.1 - 2.8 7.5 5.1 0.7 9.4 1.6 1.7 1 1 1 2 2 2 0 Cytochrome Cytochrome b558 alpha-subunit GTP_EFTU PF00009.27 EXF76283.1 - 2.2e-52 177.4 0.0 5.2e-52 176.2 0.0 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_II PF14492.6 EXF76283.1 - 6.1e-23 80.7 0.0 1.3e-22 79.7 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 EXF76283.1 - 4e-11 42.8 0.0 5.1e-05 23.2 0.0 2.7 2 0 0 2 2 2 2 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 EXF76283.1 - 1.4e-05 25.4 0.0 3.7e-05 24.0 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_IV PF03764.18 EXF76283.1 - 0.0003 20.5 0.0 0.00069 19.4 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G, domain IV RF3_C PF16658.5 EXF76283.1 - 0.00097 19.0 0.0 0.012 15.4 0.0 2.3 2 0 0 2 2 2 1 Class II release factor RF3, C-terminal domain MMR_HSR1 PF01926.23 EXF76283.1 - 0.027 14.6 0.0 0.069 13.2 0.0 1.8 2 0 0 2 2 2 0 50S ribosome-binding GTPase MmgE_PrpD PF03972.14 EXF76284.1 - 3.9e-39 134.4 8.5 5.4e-21 74.6 5.0 2.1 1 1 1 2 2 2 2 MmgE/PrpD family NAD_binding_5 PF07994.12 EXF76284.1 - 0.1 12.0 0.0 0.13 11.7 0.0 1.2 1 0 0 1 1 1 0 Myo-inositol-1-phosphate synthase Cupin_1 PF00190.22 EXF76285.1 - 7.5e-16 58.1 0.2 1.3e-15 57.4 0.2 1.2 1 0 0 1 1 1 1 Cupin Cupin_2 PF07883.11 EXF76285.1 - 0.043 13.5 0.0 0.1 12.4 0.0 1.7 1 1 0 1 1 1 0 Cupin domain SUN PF03856.13 EXF76286.1 - 1.2e-73 247.6 13.3 1.7e-73 247.1 13.3 1.2 1 0 0 1 1 1 1 Beta-glucosidase (SUN family) DUF572 PF04502.13 EXF76286.1 - 2 8.0 5.7 2.9 7.4 5.7 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) MFS_1 PF07690.16 EXF76287.1 - 2.6e-36 125.3 29.3 2.8e-36 125.2 27.3 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily LCM PF04072.14 EXF76289.1 - 3.7e-20 72.7 0.0 1.3e-19 70.9 0.0 1.9 2 1 0 2 2 2 1 Leucine carboxyl methyltransferase Mito_carr PF00153.27 EXF76290.1 - 0.13 12.2 0.1 13 5.8 0.0 2.4 2 0 0 2 2 2 0 Mitochondrial carrier protein Kinesin PF00225.23 EXF76291.1 - 7.6e-113 376.8 0.4 7.6e-113 376.8 0.4 1.8 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 EXF76291.1 - 3.2e-27 95.3 0.1 1.5e-26 93.2 0.1 2.2 1 0 0 1 1 1 1 Microtubule binding UQ_con PF00179.26 EXF76292.1 - 5.4e-52 175.2 0.1 6.1e-52 175.0 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EXF76292.1 - 0.00062 19.5 0.0 0.00069 19.3 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 EXF76292.1 - 0.038 14.3 0.0 0.048 13.9 0.0 1.4 1 1 0 1 1 1 0 RWD domain Thiolase_N PF00108.23 EXF76293.1 - 1.4e-88 296.6 0.3 2.4e-88 295.9 0.3 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EXF76293.1 - 1.9e-37 127.6 1.0 4.3e-37 126.5 1.0 1.6 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 EXF76293.1 - 0.001 18.7 0.6 0.0025 17.4 0.6 1.7 1 1 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain PCI PF01399.27 EXF76294.1 - 0.0003 21.3 0.0 0.022 15.3 0.0 2.5 2 0 0 2 2 2 2 PCI domain Clat_adaptor_s PF01217.20 EXF76295.1 - 3.8e-56 189.0 1.7 4.1e-56 188.8 1.7 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain zf-CCHC_2 PF13696.6 EXF76296.1 - 2.8e-13 49.4 19.8 5.1e-09 35.8 5.5 2.4 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC PF00098.23 EXF76296.1 - 0.062 13.4 10.5 0.071 13.2 1.8 2.7 2 1 0 2 2 2 0 Zinc knuckle Adeno_E3A PF05248.12 EXF76296.1 - 0.11 12.5 0.2 0.21 11.6 0.2 1.4 1 0 0 1 1 1 0 Adenovirus E3A Preseq_ALAS PF09029.10 EXF76296.1 - 0.17 12.4 1.1 0.84 10.1 1.6 1.9 2 0 0 2 2 2 0 5-aminolevulinate synthase presequence zf-Mss51 PF13824.6 EXF76296.1 - 8.4 6.6 9.0 13 6.0 4.4 2.8 2 1 1 3 3 3 0 Zinc-finger of mitochondrial splicing suppressor 51 Ist1 PF03398.14 EXF76297.1 - 3.1e-61 206.1 2.1 3.1e-61 206.1 2.1 2.0 3 0 0 3 3 3 1 Regulator of Vps4 activity in the MVB pathway TFIID-18kDa PF02269.16 EXF76297.1 - 4.3e-27 94.0 2.0 2.9e-26 91.3 0.2 3.0 4 0 0 4 4 4 1 Transcription initiation factor IID, 18kD subunit Myc_N PF01056.18 EXF76297.1 - 0.05 13.5 0.7 0.18 11.7 0.3 2.0 2 0 0 2 2 2 0 Myc amino-terminal region Citrate_synt PF00285.21 EXF76298.1 - 3.8e-71 240.1 0.0 5.5e-71 239.5 0.0 1.2 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain Fungal_trans_2 PF11951.8 EXF76298.1 - 5e-06 25.6 1.0 8.3e-05 21.6 0.1 2.3 2 0 0 2 2 2 2 Fungal specific transcription factor domain G-patch_2 PF12656.7 EXF76298.1 - 0.0085 16.2 0.0 0.02 15.0 0.0 1.6 1 0 0 1 1 1 1 G-patch domain DUF3500 PF12006.8 EXF76299.1 - 3.6e-72 243.3 0.0 4.1e-72 243.2 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3500) p450 PF00067.22 EXF76300.1 - 3.1e-42 144.9 0.0 1.2e-27 96.8 0.0 2.5 2 1 0 2 2 2 2 Cytochrome P450 DAO PF01266.24 EXF76302.1 - 1.7e-38 133.1 0.2 2.1e-38 132.8 0.2 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EXF76302.1 - 0.00025 21.2 0.1 0.00068 19.8 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 EXF76302.1 - 0.00042 19.7 0.0 0.028 13.7 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EXF76302.1 - 0.0021 18.0 0.5 0.028 14.4 0.1 2.2 2 0 0 2 2 2 1 FAD-NAD(P)-binding HI0933_like PF03486.14 EXF76302.1 - 0.017 13.9 0.1 3.6 6.2 0.1 2.1 2 0 0 2 2 2 0 HI0933-like protein FAD_binding_2 PF00890.24 EXF76302.1 - 0.039 13.0 2.1 0.56 9.2 2.1 2.1 1 1 0 1 1 1 0 FAD binding domain Amino_oxidase PF01593.24 EXF76302.1 - 0.067 12.5 0.0 0.095 12.0 0.0 1.2 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase Thi4 PF01946.17 EXF76302.1 - 0.069 12.4 0.0 0.11 11.7 0.0 1.2 1 0 0 1 1 1 0 Thi4 family Lycopene_cycl PF05834.12 EXF76302.1 - 0.077 12.0 0.2 0.15 11.0 0.1 1.5 2 0 0 2 2 2 0 Lycopene cyclase protein K_oxygenase PF13434.6 EXF76302.1 - 0.11 11.6 0.0 0.16 11.1 0.0 1.2 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.14 EXF76302.1 - 0.13 11.4 0.0 4.4 6.4 0.1 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase HGD-D PF06050.13 EXF76303.1 - 0.08 12.7 0.0 0.38 10.5 0.0 1.8 2 0 0 2 2 2 0 2-hydroxyglutaryl-CoA dehydratase, D-component PDZ_1 PF12812.7 EXF76304.1 - 5.7e-53 176.9 0.1 6.8e-35 118.9 0.0 2.6 2 0 0 2 2 2 2 PDZ-like domain Trypsin_2 PF13365.6 EXF76304.1 - 1.8e-22 80.9 6.3 1.9e-20 74.3 0.2 2.8 3 0 0 3 3 3 2 Trypsin-like peptidase domain PDZ_2 PF13180.6 EXF76304.1 - 4.6e-13 49.3 4.2 1e-05 25.8 0.2 4.5 4 0 0 4 4 4 3 PDZ domain PDZ_6 PF17820.1 EXF76304.1 - 6.9e-12 45.0 0.0 3e-05 23.8 0.4 3.7 3 0 0 3 3 3 3 PDZ domain PDZ PF00595.24 EXF76304.1 - 8.2e-08 32.5 0.0 0.00086 19.6 0.0 3.7 4 0 0 4 4 4 2 PDZ domain Tricorn_PDZ PF14685.6 EXF76304.1 - 0.0017 18.2 0.8 0.027 14.4 0.3 3.1 4 0 0 4 4 4 1 Tricorn protease PDZ domain Trypsin PF00089.26 EXF76304.1 - 0.0023 17.8 0.0 0.015 15.1 0.0 2.4 3 0 0 3 3 3 1 Trypsin 4HPAD_g_N PF18671.1 EXF76304.1 - 0.071 12.8 0.0 0.25 11.1 0.0 2.0 1 0 0 1 1 1 0 4-Hydroxyphenylacetate decarboxylase subunit gamma N-terminal Peptidase_S46 PF10459.9 EXF76304.1 - 0.17 10.5 0.4 0.31 9.6 0.2 1.4 2 0 0 2 2 2 0 Peptidase S46 DnaJ PF00226.31 EXF76305.1 - 2.1e-22 79.0 1.6 4.5e-22 77.9 1.6 1.6 1 0 0 1 1 1 1 DnaJ domain CDC73_C PF05179.14 EXF76306.1 - 3.1e-53 179.7 0.0 5e-53 179.0 0.0 1.4 1 0 0 1 1 1 1 RNA pol II accessory factor, Cdc73 family, C-terminal Bystin PF05291.11 EXF76307.1 - 1.1e-124 415.4 0.0 1.4e-124 415.1 0.0 1.1 1 0 0 1 1 1 1 Bystin DUF383 PF04063.14 EXF76308.1 - 5.7e-67 225.1 0.8 6.9e-65 218.3 0.2 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF383) DUF384 PF04064.13 EXF76308.1 - 5.3e-21 74.2 0.2 1.5e-20 72.8 0.2 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF384) Adaptin_N PF01602.20 EXF76308.1 - 0.012 14.2 0.3 0.023 13.3 0.3 1.4 1 0 0 1 1 1 0 Adaptin N terminal region NTP_transf_9 PF04248.12 EXF76309.1 - 1.5e-33 114.5 1.6 1.8e-33 114.3 1.6 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF427) RSN1_7TM PF02714.15 EXF76310.1 - 2.3e-79 266.5 18.3 2.3e-79 266.5 18.3 2.3 3 0 0 3 3 3 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 EXF76310.1 - 3.8e-41 140.5 0.3 3.8e-41 140.5 0.3 3.3 3 1 1 4 4 4 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 EXF76310.1 - 1.6e-28 100.1 1.2 1e-15 58.5 0.2 2.5 2 0 0 2 2 2 2 Cytosolic domain of 10TM putative phosphate transporter PHM7_ext PF12621.8 EXF76310.1 - 1.7e-15 56.9 0.0 4.9e-15 55.5 0.0 1.8 1 0 0 1 1 1 1 Extracellular tail, of 10TM putative phosphate transporter FAD_binding_3 PF01494.19 EXF76311.1 - 5.8e-18 65.3 0.0 7.9e-17 61.5 0.0 2.0 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 EXF76311.1 - 1.6e-07 31.4 0.3 3.9e-07 30.2 0.3 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EXF76311.1 - 0.00044 19.9 1.2 0.0033 17.1 1.5 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EXF76311.1 - 0.0014 17.9 0.4 0.004 16.4 0.4 1.4 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EXF76311.1 - 0.0026 16.9 0.8 0.0047 16.1 0.8 1.4 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.6 EXF76311.1 - 0.0096 15.2 0.2 0.028 13.7 0.6 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase ThiF PF00899.21 EXF76311.1 - 0.019 14.3 0.1 0.035 13.5 0.1 1.4 1 0 0 1 1 1 0 ThiF family Thi4 PF01946.17 EXF76311.1 - 0.056 12.7 0.1 0.099 11.9 0.1 1.3 1 0 0 1 1 1 0 Thi4 family GIDA PF01134.22 EXF76311.1 - 0.18 10.9 1.1 0.26 10.3 1.1 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A HI0933_like PF03486.14 EXF76311.1 - 0.25 10.0 0.6 0.42 9.3 0.6 1.3 1 0 0 1 1 1 0 HI0933-like protein HgmA PF04209.13 EXF76314.1 - 1.7e-132 442.2 0.2 3.2e-132 441.2 0.2 1.4 1 1 0 1 1 1 1 homogentisate 1,2-dioxygenase RibD_C PF01872.17 EXF76315.1 - 1.6e-37 129.3 0.0 1.8e-37 129.1 0.0 1.0 1 0 0 1 1 1 1 RibD C-terminal domain Transp_cyt_pur PF02133.15 EXF76316.1 - 8.5e-27 94.0 26.3 2.1e-26 92.7 26.3 1.6 1 1 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin p450 PF00067.22 EXF76317.1 - 1.3e-60 205.5 0.0 1.7e-60 205.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 PfkB PF00294.24 EXF76318.1 - 2.6e-56 191.1 0.6 3e-56 190.9 0.6 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase DDDD PF10161.9 EXF76319.1 - 0.18 11.6 0.3 0.74 9.6 0.0 2.1 1 1 1 2 2 2 0 Putative mitochondrial precursor protein UQ_con PF00179.26 EXF76320.1 - 4.4e-10 39.3 0.0 6.9e-10 38.7 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Ccdc124 PF06244.12 EXF76321.1 - 1.7e-29 103.0 18.3 1.4e-28 100.0 18.3 2.1 1 1 0 1 1 1 1 Coiled-coil domain-containing protein 124 /Oxs1 MFS_1 PF07690.16 EXF76322.1 - 7.2e-39 133.7 11.5 7.2e-39 133.7 11.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF76322.1 - 5.7e-12 45.2 1.1 5.7e-12 45.2 1.1 2.1 2 0 0 2 2 2 1 Sugar (and other) transporter MFS_3 PF05977.13 EXF76322.1 - 0.033 12.6 2.3 0.14 10.5 2.4 1.8 1 1 0 1 1 1 0 Transmembrane secretion effector Antimicrobial24 PF16049.5 EXF76322.1 - 0.094 12.7 4.8 2.4 8.2 0.3 2.7 2 0 0 2 2 2 0 Frog antimicrobial peptide Fungal_trans PF04082.18 EXF76323.1 - 9.5e-31 106.8 0.0 1.5e-30 106.2 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF76323.1 - 6.3e-09 35.8 9.5 1e-08 35.2 9.5 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Phage_ASH PF10554.9 EXF76323.1 - 0.0048 17.2 0.1 0.017 15.5 0.1 1.9 1 0 0 1 1 1 1 Ash protein family SUIM_assoc PF16619.5 EXF76323.1 - 1 9.5 16.2 4.3 7.5 0.2 3.4 2 1 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 bZIP_1 PF00170.21 EXF76324.1 - 1.4e-09 37.9 15.8 1.4e-09 37.9 15.8 2.4 2 0 0 2 2 2 1 bZIP transcription factor bZIP_Maf PF03131.17 EXF76324.1 - 4.2e-08 33.6 13.4 1.2e-07 32.1 13.4 1.7 1 0 0 1 1 1 1 bZIP Maf transcription factor bZIP_2 PF07716.15 EXF76324.1 - 0.00053 20.0 14.9 0.00053 20.0 14.9 2.6 2 1 1 3 3 3 1 Basic region leucine zipper UPF0242 PF06785.11 EXF76324.1 - 0.041 14.0 20.2 0.076 13.1 20.2 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Sec5 PF15469.6 EXF76324.1 - 0.046 13.5 6.0 0.091 12.6 6.0 1.4 1 0 0 1 1 1 0 Exocyst complex component Sec5 DUF2205 PF10224.9 EXF76324.1 - 0.096 12.7 10.0 0.1 12.6 8.4 1.9 1 1 0 1 1 1 0 Short coiled-coil protein CENP-F_leu_zip PF10473.9 EXF76324.1 - 0.37 10.8 20.9 5.8 6.9 21.3 2.4 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Fmp27_WPPW PF10359.9 EXF76324.1 - 0.72 8.6 12.3 1.2 7.9 12.3 1.3 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain DUF4441 PF14536.6 EXF76324.1 - 0.8 9.9 4.0 2.2 8.5 3.9 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4441) DUF874 PF05917.11 EXF76324.1 - 2.4 7.1 10.5 3.6 6.5 10.5 1.2 1 0 0 1 1 1 0 Helicobacter pylori protein of unknown function (DUF874) FapA PF03961.13 EXF76324.1 - 2.7 6.5 10.2 4 5.9 10.2 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF5320 PF17253.2 EXF76324.1 - 4.3 8.5 6.7 5.5 8.1 0.2 2.9 1 1 1 2 2 2 0 Family of unknown function (DUF5320) 5_nucleotid PF05761.14 EXF76324.1 - 4.3 6.1 9.0 6.7 5.5 9.0 1.2 1 0 0 1 1 1 0 5' nucleotidase family GBP_C PF02841.14 EXF76324.1 - 4.4 6.6 17.6 9.3 5.6 17.6 1.5 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain Mob1_phocein PF03637.17 EXF76325.1 - 5e-43 147.0 0.0 1.2e-42 145.8 0.0 1.6 1 1 0 1 1 1 1 Mob1/phocein family Leo1 PF04004.13 EXF76326.1 - 2.5e-34 118.5 0.0 4.3e-34 117.7 0.0 1.4 1 0 0 1 1 1 1 Leo1-like protein tRNA_deacylase PF04414.12 EXF76326.1 - 0.19 11.2 0.0 0.31 10.5 0.0 1.3 1 0 0 1 1 1 0 D-aminoacyl-tRNA deacylase DUF3336 PF11815.8 EXF76327.1 - 1.4e-36 125.3 0.0 3.8e-35 120.6 0.0 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF3336) Patatin PF01734.22 EXF76327.1 - 8.1e-13 49.0 1.1 1.5e-12 48.2 0.1 1.9 2 0 0 2 2 2 1 Patatin-like phospholipase Lipase_GDSL_2 PF13472.6 EXF76329.1 - 2.1e-24 86.9 2.9 3.8e-24 86.1 2.9 1.4 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EXF76329.1 - 5.5e-11 42.8 0.0 9.2e-11 42.1 0.0 1.4 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase VWA_3 PF13768.6 EXF76329.1 - 0.022 14.7 0.0 0.081 12.9 0.0 1.9 2 0 0 2 2 2 0 von Willebrand factor type A domain Ferritin_2 PF13668.6 EXF76330.1 - 2.6e-44 150.7 0.1 4.3e-44 150.0 0.1 1.4 1 0 0 1 1 1 1 Ferritin-like domain YoaP PF14268.6 EXF76330.1 - 0.056 13.0 0.1 0.13 11.8 0.1 1.6 1 0 0 1 1 1 0 YoaP-like FMN_dh PF01070.18 EXF76331.1 - 1.5e-118 395.8 0.0 1.7e-118 395.6 0.0 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Glu_synthase PF01645.17 EXF76331.1 - 1.6e-05 24.2 0.3 2.4e-05 23.6 0.3 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.25 EXF76331.1 - 0.00015 20.9 1.0 0.00051 19.2 0.6 1.8 1 1 0 2 2 2 1 IMP dehydrogenase / GMP reductase domain ThiG PF05690.14 EXF76331.1 - 0.0019 17.6 0.6 0.13 11.5 0.7 2.6 3 0 0 3 3 3 1 Thiazole biosynthesis protein ThiG NMO PF03060.15 EXF76331.1 - 0.0024 17.3 1.4 0.0037 16.7 1.4 1.2 1 0 0 1 1 1 1 Nitronate monooxygenase His_biosynth PF00977.21 EXF76331.1 - 0.0096 15.4 0.8 0.051 13.0 0.7 2.0 1 1 1 2 2 2 1 Histidine biosynthesis protein SLD5_C PF16922.5 EXF76332.1 - 1.2e-13 51.0 0.0 1.9e-13 50.3 0.0 1.4 1 0 0 1 1 1 1 DNA replication complex GINS protein SLD5 C-terminus Sld5 PF05916.11 EXF76332.1 - 2.4e-06 27.9 0.1 7.9e-06 26.3 0.0 1.8 2 0 0 2 2 2 1 GINS complex protein Sua5_yciO_yrdC PF01300.18 EXF76333.1 - 5.8e-54 182.3 0.0 9.1e-54 181.7 0.0 1.3 1 0 0 1 1 1 1 Telomere recombination SUA5 PF03481.13 EXF76333.1 - 3.7e-30 105.2 0.0 6.1e-30 104.5 0.0 1.4 1 0 0 1 1 1 1 Putative GTP-binding controlling metal-binding Clat_adaptor_s PF01217.20 EXF76334.1 - 3.9e-17 62.5 1.3 1.8e-16 60.4 1.3 1.8 1 1 0 1 1 1 1 Clathrin adaptor complex small chain MCM PF00493.23 EXF76335.1 - 1.5e-100 335.0 0.0 2.1e-100 334.5 0.0 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EXF76335.1 - 3.4e-39 133.6 0.6 6.2e-39 132.7 0.6 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EXF76335.1 - 1.1e-27 96.3 4.9 2.9e-27 94.9 4.9 1.8 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 EXF76335.1 - 9.4e-16 58.3 0.1 3.6e-15 56.4 0.0 2.0 2 0 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.21 EXF76335.1 - 2.3e-05 23.9 0.0 0.00043 19.7 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EXF76335.1 - 4e-05 23.6 0.1 0.0003 20.8 0.0 2.6 2 2 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 EXF76335.1 - 0.0012 18.7 0.0 0.0046 16.8 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EXF76335.1 - 0.13 12.0 0.2 2.6 7.7 0.0 2.7 3 0 0 3 3 3 0 Sigma-54 interaction domain Methyltransf_23 PF13489.6 EXF76336.1 - 1.3e-16 60.9 0.0 2.1e-16 60.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF76336.1 - 7.4e-06 26.6 0.0 0.015 16.0 0.0 2.4 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_31 PF13847.6 EXF76336.1 - 0.00013 21.8 0.0 0.059 13.2 0.0 2.4 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 EXF76336.1 - 0.01 16.6 0.0 0.065 14.0 0.0 2.2 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.12 EXF76336.1 - 0.011 16.4 0.0 0.12 13.1 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase domain MTS PF05175.14 EXF76336.1 - 0.028 14.0 0.0 0.049 13.2 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain Ubie_methyltran PF01209.18 EXF76336.1 - 0.12 11.7 0.0 21 4.4 0.0 2.6 3 0 0 3 3 3 0 ubiE/COQ5 methyltransferase family Methyltransf_2 PF00891.18 EXF76336.1 - 0.14 11.4 0.0 6.4 6.0 0.0 2.7 3 0 0 3 3 3 0 O-methyltransferase domain Cys_Met_Meta_PP PF01053.20 EXF76337.1 - 2.8e-25 88.7 0.0 4.3e-25 88.1 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 EXF76337.1 - 0.00032 20.0 0.0 0.00053 19.3 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II ADK PF00406.22 EXF76338.1 - 3.4e-45 153.8 0.0 4.4e-45 153.5 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 EXF76338.1 - 3e-35 121.6 0.0 4.1e-35 121.2 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EXF76338.1 - 3e-05 24.6 0.0 5.7e-05 23.7 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EXF76338.1 - 0.0005 20.3 0.0 0.0019 18.3 0.0 1.9 1 1 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.17 EXF76338.1 - 0.0073 16.0 0.1 2.6 7.7 0.0 2.2 2 0 0 2 2 2 2 Thymidylate kinase Sfi1_C PF10638.9 EXF76338.1 - 0.23 12.2 4.1 2.3 9.0 0.7 2.5 2 0 0 2 2 2 0 Spindle body associated protein C-terminus PCI PF01399.27 EXF76339.1 - 2.2e-14 53.8 0.3 1.1e-13 51.5 0.0 2.3 3 0 0 3 3 3 1 PCI domain eIF3m_C_helix PF18005.1 EXF76339.1 - 6.1e-12 45.0 0.2 1.2e-11 44.1 0.2 1.5 1 0 0 1 1 1 1 eIF3 subunit M, C-terminal helix FHA PF00498.26 EXF76340.1 - 2.6e-08 34.1 0.1 6.3e-08 32.8 0.1 1.7 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 EXF76340.1 - 1.8e-05 25.0 0.0 3.4e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain Pkinase PF00069.25 EXF76340.1 - 0.0008 18.9 0.0 0.0011 18.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain ArfGap PF01412.18 EXF76341.1 - 9.7e-33 112.7 0.2 4.5e-32 110.6 0.0 2.3 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf BAR_3 PF16746.5 EXF76341.1 - 3.8e-24 85.7 14.9 6e-24 85.1 14.9 1.2 1 0 0 1 1 1 1 BAR domain of APPL family PH PF00169.29 EXF76341.1 - 9.3e-13 48.6 0.4 2.7e-12 47.1 0.4 1.9 1 0 0 1 1 1 1 PH domain EMP24_GP25L PF01105.24 EXF76341.1 - 0.093 12.7 4.0 0.68 9.9 1.8 2.4 2 0 0 2 2 2 0 emp24/gp25L/p24 family/GOLD tRNA-synt_2 PF00152.20 EXF76341.1 - 0.22 10.5 8.1 0.36 9.8 8.1 1.2 1 0 0 1 1 1 0 tRNA synthetases class II (D, K and N) ANAPC9 PF12856.7 EXF76341.1 - 0.4 10.9 4.3 0.95 9.7 4.3 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 9 PH_9 PF15410.6 EXF76341.1 - 0.71 10.3 4.5 1.5 9.2 1.1 3.0 2 1 0 2 2 2 0 Pleckstrin homology domain FTO_CTD PF12934.7 EXF76341.1 - 0.97 9.2 3.8 0.81 9.4 0.2 2.3 2 0 0 2 2 2 0 FTO C-terminal domain BAR PF03114.18 EXF76341.1 - 2 8.0 16.3 0.41 10.3 12.6 1.7 1 1 0 1 1 1 0 BAR domain ATP-synt_E PF05680.12 EXF76341.1 - 5.7 7.4 12.4 0.21 12.0 0.3 2.8 3 0 0 3 3 3 0 ATP synthase E chain Membr_traf_MHD PF10540.9 EXF76342.1 - 2.5e-18 66.7 0.3 4e-15 56.3 0.3 3.1 2 1 0 2 2 2 1 Munc13 (mammalian uncoordinated) homology domain C2 PF00168.30 EXF76342.1 - 5.2e-17 62.0 0.0 2.6e-16 59.8 0.0 2.2 2 0 0 2 2 2 1 C2 domain DUF810 PF05664.11 EXF76342.1 - 4e-06 25.7 0.5 4e-06 25.7 0.5 1.7 2 0 0 2 2 2 1 Plant family of unknown function (DUF810) Astacin PF01400.24 EXF76343.1 - 2.4e-34 118.6 0.0 2.5e-33 115.3 0.0 2.1 1 1 0 1 1 1 1 Astacin (Peptidase family M12A) Peptidase_M10 PF00413.24 EXF76343.1 - 0.048 13.5 2.2 0.95 9.3 2.2 2.5 1 1 0 1 1 1 0 Matrixin Ecl1 PF12855.7 EXF76345.1 - 4.8e-15 57.1 22.7 6.3e-15 56.8 22.7 1.2 1 0 0 1 1 1 1 ECL1/2/3 zinc binding proteins HipA_C PF07804.12 EXF76345.1 - 0.082 12.6 0.1 0.1 12.3 0.1 1.2 1 0 0 1 1 1 0 HipA-like C-terminal domain zf-MYND PF01753.18 EXF76345.1 - 0.091 12.9 2.0 0.17 12.0 2.0 1.4 1 0 0 1 1 1 0 MYND finger Terpene_synth_C PF03936.16 EXF76346.1 - 0.00072 19.0 0.0 0.00087 18.7 0.0 1.2 1 0 0 1 1 1 1 Terpene synthase family, metal binding domain Redoxin PF08534.10 EXF76347.1 - 9.1e-25 87.1 0.0 1.8e-24 86.1 0.0 1.4 1 0 0 1 1 1 1 Redoxin IBR PF01485.21 EXF76347.1 - 7.5e-21 74.1 45.3 2.9e-10 40.2 4.7 4.5 3 1 1 4 4 4 3 IBR domain, a half RING-finger domain zf-C3HC4 PF00097.25 EXF76347.1 - 1.2e-05 25.1 39.9 0.00028 20.7 5.6 4.3 3 1 1 4 4 4 3 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EXF76347.1 - 0.00054 20.2 43.0 0.00088 19.6 7.0 3.9 2 1 1 3 3 3 2 Ring finger domain zf-C3HC4_2 PF13923.6 EXF76347.1 - 0.0054 16.5 5.4 0.0054 16.5 5.4 4.8 3 1 1 4 4 4 2 Zinc finger, C3HC4 type (RING finger) UN_NPL4 PF11543.8 EXF76347.1 - 0.049 14.1 0.0 0.11 13.0 0.0 1.5 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 zf-RING_UBOX PF13445.6 EXF76347.1 - 0.054 13.5 35.2 0.072 13.1 5.1 3.8 3 1 0 3 3 3 0 RING-type zinc-finger HbrB PF08539.11 EXF76347.1 - 0.11 12.5 0.0 0.22 11.5 0.0 1.4 1 0 0 1 1 1 0 HbrB-like zf-C3HC4_4 PF15227.6 EXF76347.1 - 0.91 9.7 30.9 0.22 11.7 1.4 4.2 3 1 0 3 3 3 0 zinc finger of C3HC4-type, RING XPG_I PF00867.18 EXF76348.1 - 1.6e-23 82.9 0.0 4.2e-23 81.5 0.0 1.8 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.17 EXF76348.1 - 1.7e-22 79.8 0.0 4e-22 78.6 0.0 1.6 1 0 0 1 1 1 1 XPG N-terminal domain 5_3_exonuc PF01367.20 EXF76348.1 - 0.00011 22.8 0.1 0.003 18.1 0.0 2.3 2 0 0 2 2 2 1 5'-3' exonuclease, C-terminal SAM fold XPG_I_2 PF12813.7 EXF76348.1 - 0.00071 19.1 0.0 0.0016 18.0 0.0 1.6 1 0 0 1 1 1 1 XPG domain containing Tma16 PF11176.8 EXF76349.1 - 2.4e-46 157.2 1.2 2.9e-46 157.0 1.2 1.1 1 0 0 1 1 1 1 Translation machinery-associated protein 16 CHASE7 PF17151.4 EXF76349.1 - 0.017 14.7 0.2 0.024 14.3 0.2 1.2 1 0 0 1 1 1 0 Periplasmic sensor domain baeRF_family6 PF18848.1 EXF76349.1 - 0.084 13.3 0.4 0.11 12.9 0.4 1.3 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 6 MAM33 PF02330.16 EXF76350.1 - 1.1e-77 260.8 1.2 1.6e-77 260.2 1.2 1.3 1 0 0 1 1 1 1 Mitochondrial glycoprotein Lyase_aromatic PF00221.19 EXF76351.1 - 2.7e-153 511.0 10.0 3.5e-153 510.6 10.0 1.1 1 0 0 1 1 1 1 Aromatic amino acid lyase Methyltransf_31 PF13847.6 EXF76352.1 - 7.2e-15 55.1 0.0 1.7e-14 53.9 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EXF76352.1 - 5.2e-14 52.4 0.0 8e-14 51.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF76352.1 - 1.6e-13 51.2 0.0 3.2e-13 50.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF76352.1 - 4.6e-12 46.4 0.0 8.2e-12 45.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF76352.1 - 9.2e-12 45.6 0.0 1.5e-11 44.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 EXF76352.1 - 1.5e-05 24.5 0.0 4.1e-05 23.1 0.0 1.7 1 1 0 1 1 1 1 Putative methyltransferase Methyltransf_2 PF00891.18 EXF76352.1 - 9.1e-05 21.8 0.0 0.00032 20.1 0.0 1.9 2 0 0 2 2 2 1 O-methyltransferase domain MTS PF05175.14 EXF76352.1 - 0.00015 21.4 0.0 0.00024 20.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain MetW PF07021.12 EXF76352.1 - 0.00017 21.3 0.0 0.00026 20.6 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW RrnaAD PF00398.20 EXF76352.1 - 0.011 14.9 0.0 0.016 14.3 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase CMAS PF02353.20 EXF76352.1 - 0.042 13.1 0.0 0.093 12.0 0.0 1.5 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase PCMT PF01135.19 EXF76352.1 - 0.064 13.0 0.0 0.097 12.4 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Ubie_methyltran PF01209.18 EXF76352.1 - 0.072 12.4 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Scytalone_dh PF02982.14 EXF76353.1 - 4.7e-82 273.5 0.4 5.3e-82 273.3 0.4 1.0 1 0 0 1 1 1 1 Scytalone dehydratase SnoaL_4 PF13577.6 EXF76353.1 - 3.5e-08 33.6 0.1 4.4e-08 33.3 0.1 1.2 1 0 0 1 1 1 1 SnoaL-like domain CAP PF00188.26 EXF76354.1 - 2.3e-21 76.9 2.2 2.3e-21 76.9 2.2 1.6 2 0 0 2 2 2 1 Cysteine-rich secretory protein family Calici_coat PF00915.20 EXF76354.1 - 3.6 6.4 15.4 0.071 12.0 3.9 2.1 1 1 1 2 2 2 0 Calicivirus coat protein AbfS_sensor PF18225.1 EXF76355.1 - 0.023 14.6 0.0 9.4 6.2 0.0 3.1 3 0 0 3 3 3 0 Sensor histidine kinase (AbfS) sensor domain Oxysterol_BP PF01237.18 EXF76357.1 - 1.4e-49 168.9 0.0 2.5e-47 161.5 0.0 2.1 1 1 0 1 1 1 1 Oxysterol-binding protein Apq12 PF12716.7 EXF76358.1 - 4.4e-16 58.6 14.1 7.8e-16 57.8 14.1 1.4 1 0 0 1 1 1 1 Nuclear pore assembly and biogenesis Antimicrobial_7 PF08102.11 EXF76358.1 - 0.002 18.3 0.4 0.15 12.3 0.0 2.6 3 0 0 3 3 3 1 Scorpion antimicrobial peptide YqjK PF13997.6 EXF76358.1 - 2.8 8.3 8.0 1.1 9.6 1.5 2.5 2 1 0 2 2 2 0 YqjK-like protein ATP_bind_1 PF03029.17 EXF76359.1 - 1.9e-71 240.7 0.0 2.6e-71 240.3 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_24 PF13479.6 EXF76359.1 - 0.0005 19.9 0.0 0.00081 19.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain CLP1_P PF16575.5 EXF76359.1 - 0.00053 19.8 0.0 0.0012 18.7 0.0 1.5 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_14 PF13173.6 EXF76359.1 - 0.00076 19.5 0.0 0.0019 18.2 0.0 1.8 1 1 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 EXF76359.1 - 0.0038 17.6 0.0 0.0089 16.4 0.0 1.6 1 0 0 1 1 1 1 RNA helicase AAA_18 PF13238.6 EXF76359.1 - 0.0043 17.6 0.0 0.01 16.4 0.0 1.7 1 1 0 1 1 1 1 AAA domain CbiA PF01656.23 EXF76359.1 - 0.0097 16.0 0.0 0.011 15.8 0.0 1.3 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain RsgA_GTPase PF03193.16 EXF76359.1 - 0.013 15.4 0.1 0.46 10.4 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase GTP_EFTU PF00009.27 EXF76359.1 - 0.015 14.9 0.0 3.6 7.1 0.0 2.3 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_22 PF13401.6 EXF76359.1 - 0.015 15.6 0.0 0.031 14.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EXF76359.1 - 0.018 15.2 0.0 0.027 14.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EXF76359.1 - 0.048 13.2 0.0 0.088 12.3 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_16 PF13191.6 EXF76359.1 - 0.076 13.4 0.0 0.25 11.7 0.0 1.8 2 0 0 2 2 2 0 AAA ATPase domain ABC_tran PF00005.27 EXF76359.1 - 0.078 13.5 0.0 0.16 12.5 0.0 1.5 1 0 0 1 1 1 0 ABC transporter SRP54 PF00448.22 EXF76359.1 - 0.078 12.6 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain PPV_E1_C PF00519.17 EXF76359.1 - 0.092 11.6 0.0 0.14 11.0 0.0 1.2 1 0 0 1 1 1 0 Papillomavirus helicase Cytidylate_kin PF02224.18 EXF76359.1 - 0.1 12.3 0.0 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 Cytidylate kinase AAA_29 PF13555.6 EXF76359.1 - 0.11 12.3 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Septin PF00735.18 EXF76359.1 - 0.11 11.8 0.0 0.17 11.1 0.0 1.3 1 0 0 1 1 1 0 Septin KAP_NTPase PF07693.14 EXF76359.1 - 0.11 11.7 0.0 0.2 10.9 0.0 1.3 1 1 0 1 1 1 0 KAP family P-loop domain NACHT PF05729.12 EXF76359.1 - 0.13 12.2 0.0 0.21 11.5 0.0 1.3 1 0 0 1 1 1 0 NACHT domain MMR_HSR1 PF01926.23 EXF76359.1 - 0.14 12.3 0.0 0.41 10.7 0.0 2.0 1 1 0 1 1 1 0 50S ribosome-binding GTPase cobW PF02492.19 EXF76359.1 - 0.15 11.6 0.1 7.1 6.2 0.0 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain PduV-EutP PF10662.9 EXF76359.1 - 0.15 11.8 0.0 1.7 8.4 0.0 2.2 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_25 PF13481.6 EXF76359.1 - 0.17 11.4 0.0 1.1 8.8 0.0 2.0 2 0 0 2 2 2 0 AAA domain S-AdoMet_synt_C PF02773.16 EXF76360.1 - 2.5e-65 218.6 0.6 5.4e-65 217.5 0.0 1.8 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.16 EXF76360.1 - 1.2e-45 154.6 0.0 2.4e-45 153.7 0.0 1.5 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, central domain S-AdoMet_synt_N PF00438.20 EXF76360.1 - 4.6e-43 145.9 0.4 1.1e-42 144.7 0.0 1.8 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, N-terminal domain AdoMet_Synthase PF01941.19 EXF76360.1 - 0.09 11.5 0.3 0.68 8.7 0.1 2.0 1 1 1 2 2 2 0 S-adenosylmethionine synthetase (AdoMet synthetase) TOH_N PF12549.8 EXF76361.1 - 0.012 15.5 3.4 0.031 14.1 3.4 1.7 1 0 0 1 1 1 0 Tyrosine hydroxylase N terminal PI-PLC-X PF00388.19 EXF76364.1 - 8.7e-09 35.1 0.0 1.4e-08 34.5 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain MaoC_dehydratas PF01575.19 EXF76367.1 - 5.8e-21 74.3 0.0 1.1e-20 73.5 0.0 1.4 1 0 0 1 1 1 1 MaoC like domain CAP_GLY PF01302.25 EXF76367.1 - 4.4e-12 45.8 0.1 9.1e-12 44.8 0.1 1.5 1 0 0 1 1 1 1 CAP-Gly domain LRR_8 PF13855.6 EXF76367.1 - 3.3e-11 42.8 3.0 5e-05 23.0 1.3 4.0 3 1 0 3 3 3 2 Leucine rich repeat LRR_4 PF12799.7 EXF76367.1 - 6.8e-11 42.2 0.8 0.02 15.3 0.1 4.4 2 1 1 4 4 4 4 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EXF76367.1 - 0.00027 20.8 0.6 15 5.9 0.0 5.4 6 0 0 6 6 6 0 Leucine Rich repeat zf-CCCH_4 PF18044.1 EXF76367.1 - 0.00089 19.0 3.9 0.0017 18.1 3.9 1.5 1 0 0 1 1 1 1 CCCH-type zinc finger Torus PF16131.5 EXF76367.1 - 0.0042 17.8 0.2 0.0085 16.8 0.2 1.4 1 0 0 1 1 1 1 Torus domain LRR_9 PF14580.6 EXF76367.1 - 0.0047 16.5 0.1 6.5 6.2 0.0 3.2 2 1 0 3 3 3 1 Leucine-rich repeat zf-CCCH PF00642.24 EXF76367.1 - 0.019 14.9 3.2 0.036 14.0 3.2 1.5 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) MaoC_dehydrat_N PF13452.6 EXF76367.1 - 0.023 14.8 0.0 0.47 10.6 0.0 2.5 2 0 0 2 2 2 0 N-terminal half of MaoC dehydratase LRR_1 PF00560.33 EXF76367.1 - 0.15 12.7 2.7 2.5e+02 2.9 0.0 5.3 6 0 0 6 6 5 0 Leucine Rich Repeat zf_CCCH_4 PF18345.1 EXF76367.1 - 0.35 11.0 9.2 0.64 10.1 9.2 1.5 1 0 0 1 1 1 0 Zinc finger domain Aldo_ket_red PF00248.21 EXF76368.1 - 1e-62 212.0 0.0 1.1e-62 211.9 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family WD40 PF00400.32 EXF76369.1 - 1.9e-06 28.5 8.4 0.37 11.7 0.9 5.7 6 1 0 6 6 6 3 WD domain, G-beta repeat ATP-synt_E PF05680.12 EXF76370.1 - 7.3e-25 87.2 0.1 7.7e-25 87.1 0.1 1.0 1 0 0 1 1 1 1 ATP synthase E chain Drf_GBD PF06371.13 EXF76370.1 - 0.038 13.6 0.0 0.039 13.5 0.0 1.1 1 0 0 1 1 1 0 Diaphanous GTPase-binding Domain STT3 PF02516.14 EXF76371.1 - 2e-144 482.2 34.3 1.5e-139 466.1 31.9 2.1 2 0 0 2 2 2 2 Oligosaccharyl transferase STT3 subunit DUF2752 PF10825.8 EXF76372.1 - 0.033 14.2 2.1 2.6 8.2 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2752) DZR PF12773.7 EXF76372.1 - 9 6.4 8.7 9.1e+02 -0.0 8.7 3.1 1 1 0 1 1 1 0 Double zinc ribbon Podoplanin PF05808.11 EXF76373.1 - 3.9e-05 23.8 6.0 5.2e-05 23.4 0.1 3.2 2 1 1 3 3 3 1 Podoplanin VSP PF03302.13 EXF76373.1 - 0.00012 21.1 0.2 0.00017 20.6 0.2 1.2 1 0 0 1 1 1 1 Giardia variant-specific surface protein DUF4690 PF15756.5 EXF76373.1 - 0.00032 21.2 5.6 0.00032 21.2 5.6 3.2 2 2 0 3 3 3 1 Small Novel Rich in Cartilage Zip PF02535.22 EXF76373.1 - 0.0039 16.5 0.5 0.0068 15.7 0.5 1.3 1 0 0 1 1 1 1 ZIP Zinc transporter Phage_holin_2_4 PF16082.5 EXF76373.1 - 0.0058 16.3 0.5 0.014 15.1 0.5 1.6 1 0 0 1 1 1 1 Bacteriophage holin family, superfamily II-like Yip1 PF04893.17 EXF76373.1 - 0.018 14.7 0.1 0.03 14.1 0.1 1.2 1 0 0 1 1 1 0 Yip1 domain Amnionless PF14828.6 EXF76373.1 - 0.16 10.8 0.0 0.22 10.3 0.0 1.2 1 0 0 1 1 1 0 Amnionless YebO PF13974.6 EXF76373.1 - 1.1 9.4 5.0 0.26 11.4 0.6 2.0 2 0 0 2 2 2 0 YebO-like protein SARAF PF06682.12 EXF76373.1 - 2.1 7.9 7.2 0.56 9.8 0.2 2.1 1 1 1 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis TFIIA PF03153.13 EXF76374.1 - 9.7e-91 305.8 13.2 1.6e-90 305.1 13.2 1.3 1 1 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit ANAPC4_WD40 PF12894.7 EXF76375.1 - 8.7e-18 64.4 5.4 3.3e-05 24.1 0.1 4.4 3 1 1 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EXF76375.1 - 1.9e-16 60.1 18.3 0.00033 21.4 0.1 6.5 7 0 0 7 7 7 5 WD domain, G-beta repeat Ge1_WD40 PF16529.5 EXF76375.1 - 2.7e-06 26.6 0.1 0.00033 19.7 0.0 3.3 2 1 1 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 EXF76375.1 - 3.7e-06 27.0 0.2 0.00059 19.8 0.1 2.6 1 1 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A Kelch_4 PF13418.6 EXF76376.1 - 2.6e-25 88.2 10.7 9.1e-09 35.2 0.0 5.0 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_6 PF13964.6 EXF76376.1 - 6e-22 77.1 4.4 7.7e-05 22.8 0.0 5.1 3 1 2 5 5 5 4 Kelch motif Kelch_5 PF13854.6 EXF76376.1 - 9.4e-22 76.6 3.9 1.5e-06 28.0 0.0 4.8 4 0 0 4 4 4 4 Kelch motif Kelch_1 PF01344.25 EXF76376.1 - 1.3e-19 69.5 1.6 0.00012 21.6 0.0 4.9 5 0 0 5 5 5 3 Kelch motif Kelch_3 PF13415.6 EXF76376.1 - 1.2e-17 63.8 3.2 1.2e-06 28.7 0.1 5.2 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_2 PF07646.15 EXF76376.1 - 8e-16 57.3 5.2 0.0019 18.1 0.0 4.8 4 0 0 4 4 4 4 Kelch motif BTB PF00651.31 EXF76376.1 - 1.9e-09 37.7 0.0 3.3e-09 37.0 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.15 EXF76376.1 - 0.027 14.6 0.0 0.052 13.6 0.0 1.4 1 0 0 1 1 1 0 BTB And C-terminal Kelch zf-C2H2 PF00096.26 EXF76377.1 - 0.00081 19.7 5.7 0.23 12.0 0.4 3.4 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_aberr PF17017.5 EXF76377.1 - 0.0022 18.2 1.3 1.4 9.0 0.1 2.2 2 0 0 2 2 2 2 Aberrant zinc-finger zf-H2C2_2 PF13465.6 EXF76377.1 - 0.0098 16.3 9.3 0.089 13.3 0.5 3.1 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 EXF76377.1 - 0.033 15.0 10.3 0.13 13.2 0.6 3.6 3 0 0 3 3 3 0 C2H2-type zinc finger HIG_1_N PF04588.13 EXF76378.1 - 6.4e-05 23.1 1.7 0.00018 21.7 1.7 1.8 1 0 0 1 1 1 1 Hypoxia induced protein conserved region DUF4079 PF13301.6 EXF76378.1 - 0.039 14.1 0.6 0.062 13.5 0.5 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF4079) Kelch_1 PF01344.25 EXF76379.1 - 2.3e-40 135.9 14.8 1.2e-08 34.4 0.3 6.3 6 0 0 6 6 6 6 Kelch motif Kelch_5 PF13854.6 EXF76379.1 - 3.4e-40 135.4 13.4 6.2e-07 29.3 0.1 6.3 6 0 0 6 6 6 6 Kelch motif Kelch_3 PF13415.6 EXF76379.1 - 1e-38 130.9 19.6 3.7e-09 36.6 0.0 6.8 7 0 0 7 7 7 6 Galactose oxidase, central domain Kelch_4 PF13418.6 EXF76379.1 - 1.3e-35 121.2 15.6 4.2e-07 29.9 0.1 6.4 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_6 PF13964.6 EXF76379.1 - 1.6e-33 113.9 15.7 1e-06 28.8 0.0 6.5 4 2 2 6 6 6 6 Kelch motif Kelch_2 PF07646.15 EXF76379.1 - 1e-31 107.7 16.0 8.9e-07 28.6 0.0 6.5 6 0 0 6 6 6 6 Kelch motif Ank_2 PF12796.7 EXF76380.1 - 1.6e-38 131.1 3.2 3.5e-08 33.9 0.1 9.3 5 2 6 11 11 11 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EXF76380.1 - 2.1e-26 91.9 15.3 1.1e-05 25.9 0.1 11.5 7 4 7 14 14 14 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 EXF76380.1 - 3e-19 68.8 9.6 0.00016 21.9 0.1 10.9 9 3 3 12 12 12 7 Ankyrin repeats (many copies) Ank PF00023.30 EXF76380.1 - 2.8e-17 62.3 23.4 0.42 11.1 0.0 15.1 17 0 0 17 17 17 4 Ankyrin repeat Ank_3 PF13606.6 EXF76380.1 - 9e-13 47.2 16.7 1 10.1 0.0 13.5 15 1 0 15 15 15 2 Ankyrin repeat NACHT PF05729.12 EXF76380.1 - 1.1e-07 32.0 0.0 2.4e-07 30.8 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 EXF76380.1 - 3.3e-05 24.3 0.1 0.00011 22.6 0.0 1.9 2 0 0 2 2 2 1 AAA ATPase domain Helo_like_N PF17111.5 EXF76380.1 - 4e-05 23.1 1.9 8.6e-05 22.0 1.9 1.6 1 0 0 1 1 1 1 Fungal N-terminal domain of STAND proteins AAA_22 PF13401.6 EXF76380.1 - 0.015 15.6 0.0 0.043 14.1 0.0 1.8 1 0 0 1 1 1 0 AAA domain CinA_KH PF18146.1 EXF76380.1 - 1 9.6 4.6 0.68 10.1 0.8 2.7 3 0 0 3 3 3 0 Damage-inducible protein CinA KH domain DUF1479 PF07350.12 EXF76381.1 - 8.1e-160 532.1 0.0 1.3e-159 531.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1479) HHH PF00633.23 EXF76381.1 - 0.067 13.1 0.3 0.18 11.7 0.3 1.8 1 0 0 1 1 1 0 Helix-hairpin-helix motif Ribosomal_60s PF00428.19 EXF76381.1 - 0.18 12.4 1.9 0.46 11.1 1.9 1.6 1 0 0 1 1 1 0 60s Acidic ribosomal protein zf-met2 PF12907.7 EXF76382.1 - 3.9e-16 58.9 3.1 6.3e-16 58.2 3.1 1.3 1 0 0 1 1 1 1 Zinc-binding 4F5 PF04419.14 EXF76382.1 - 7.7e-06 26.7 8.5 7.7e-06 26.7 8.5 1.5 2 0 0 2 2 2 1 4F5 protein family DIOX_N PF14226.6 EXF76383.1 - 1.5e-27 96.7 0.0 5.1e-26 91.7 0.0 2.6 2 1 0 2 2 2 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EXF76383.1 - 5.1e-13 49.4 0.0 9.6e-13 48.5 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily GxGYxYP_C PF14323.6 EXF76383.1 - 0.0077 16.1 0.0 0.012 15.5 0.0 1.1 1 0 0 1 1 1 1 GxGYxYP putative glycoside hydrolase C-terminal domain WD40 PF00400.32 EXF76384.1 - 1.3e-07 32.1 14.8 0.02 15.8 0.3 7.1 8 0 0 8 8 8 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EXF76384.1 - 1.2e-06 28.7 0.1 4 7.8 0.0 5.7 5 1 0 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain PQQ PF01011.21 EXF76384.1 - 0.028 14.3 0.0 0.18 11.8 0.0 2.5 1 0 0 1 1 1 0 PQQ enzyme repeat PD40 PF07676.12 EXF76384.1 - 0.058 13.4 1.1 22 5.1 0.0 4.2 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat PQQ_3 PF13570.6 EXF76384.1 - 1.3 9.6 3.9 4.1 8.0 0.4 3.9 4 0 0 4 4 4 0 PQQ-like domain RNA_pol_N PF01194.17 EXF76385.1 - 2.1e-30 104.8 0.9 2.7e-30 104.4 0.9 1.2 1 0 0 1 1 1 1 RNA polymerases N / 8 kDa subunit 7TMR-HDED PF07697.11 EXF76386.1 - 0.28 11.3 2.1 9.7 6.2 0.8 2.7 2 1 1 3 3 3 0 7TM-HD extracellular Methyltransf_16 PF10294.9 EXF76388.1 - 9.4e-18 64.5 0.0 1.7e-17 63.7 0.0 1.4 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_23 PF13489.6 EXF76388.1 - 0.012 15.4 0.0 0.02 14.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.6 EXF76388.1 - 0.025 15.3 0.0 0.07 13.8 0.0 1.9 1 1 0 1 1 1 0 Methyltransferase domain PrmA PF06325.13 EXF76388.1 - 0.04 13.3 0.0 0.071 12.5 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 EXF76388.1 - 0.044 13.3 0.0 0.11 12.1 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase small domain Dynein_light PF01221.18 EXF76393.1 - 2.3e-39 133.6 1.3 2.6e-39 133.4 1.3 1.0 1 0 0 1 1 1 1 Dynein light chain type 1 SGTA_dimer PF16546.5 EXF76393.1 - 0.033 14.0 0.5 0.048 13.5 0.5 1.2 1 0 0 1 1 1 0 Homodimerisation domain of SGTA RRM_1 PF00076.22 EXF76394.1 - 2.3e-77 254.8 1.7 3.7e-18 65.1 0.0 5.4 5 0 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EXF76394.1 - 4.7e-09 36.0 0.0 0.14 12.1 0.0 4.6 5 0 0 5 5 5 3 Occluded RNA-recognition motif Limkain-b1 PF11608.8 EXF76394.1 - 2e-06 27.8 0.3 0.69 10.0 0.0 5.7 5 1 0 5 5 5 1 Limkain b1 RRM_7 PF16367.5 EXF76394.1 - 3.4e-06 27.1 0.2 6.5 6.9 0.0 5.0 5 0 0 5 5 5 2 RNA recognition motif Nup35_RRM_2 PF14605.6 EXF76394.1 - 5.9e-06 26.2 0.0 0.98 9.5 0.0 4.3 4 0 0 4 4 4 2 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 EXF76394.1 - 1.2e-05 25.3 2.9 1.3 9.1 0.0 5.4 6 0 0 6 6 6 1 RNA binding motif Smg4_UPF3 PF03467.15 EXF76394.1 - 7.8e-05 22.8 2.8 0.0041 17.2 0.3 3.6 3 1 0 3 3 3 1 Smg-4/UPF3 family RRM_Rrp7 PF17799.1 EXF76394.1 - 0.0051 16.6 0.0 19 5.0 0.0 4.1 4 0 0 4 4 4 0 Rrp7 RRM-like N-terminal domain RRM_2 PF04059.12 EXF76394.1 - 0.041 14.1 0.0 1.7 8.9 0.0 3.1 3 0 0 3 3 3 0 RNA recognition motif 2 Peptidase_C26 PF07722.13 EXF76394.1 - 0.15 11.8 0.0 0.28 10.9 0.0 1.3 1 0 0 1 1 1 0 Peptidase C26 SET_assoc PF11767.8 EXF76394.1 - 0.18 11.5 0.0 13 5.6 0.0 3.5 4 0 0 4 4 4 0 Histone lysine methyltransferase SET associated PHM7_cyt PF14703.6 EXF76394.1 - 1.2 9.3 11.0 14 5.9 0.1 6.0 5 3 1 7 7 7 0 Cytosolic domain of 10TM putative phosphate transporter TEA PF01285.18 EXF76395.1 - 9.1e-27 92.9 0.3 2e-26 91.8 0.3 1.6 1 0 0 1 1 1 1 TEA/ATTS domain Pro_isomerase PF00160.21 EXF76397.1 - 1.2e-48 165.4 0.4 1.3e-48 165.2 0.4 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Thioredoxin_3 PF13192.6 EXF76397.1 - 0.076 13.1 0.0 0.11 12.5 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin domain E1_dh PF00676.20 EXF76397.1 - 0.13 11.2 0.0 0.35 9.8 0.1 1.6 2 0 0 2 2 2 0 Dehydrogenase E1 component zf-RING_2 PF13639.6 EXF76398.1 - 2.3e-11 43.9 6.8 3.4e-11 43.3 6.8 1.3 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 EXF76398.1 - 7.1e-08 32.1 1.3 1.1e-07 31.4 1.3 1.3 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 EXF76398.1 - 7.7e-08 32.1 6.4 1.2e-07 31.4 6.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EXF76398.1 - 1e-07 31.7 4.2 1.6e-07 31.0 4.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EXF76398.1 - 5.1e-06 26.7 9.8 2.6e-05 24.4 9.8 2.0 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 EXF76398.1 - 1.3e-05 25.0 3.8 2e-05 24.4 3.8 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 EXF76398.1 - 0.0016 18.4 1.7 0.0033 17.4 1.7 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.6 EXF76398.1 - 0.0034 17.2 2.7 0.0052 16.6 2.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EXF76398.1 - 0.0037 17.2 1.0 0.0037 17.2 1.0 2.3 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_4 PF14570.6 EXF76398.1 - 0.019 14.7 6.6 0.032 14.0 6.6 1.3 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Prok-RING_4 PF14447.6 EXF76398.1 - 0.22 11.4 4.7 0.45 10.4 4.7 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 PHD PF00628.29 EXF76398.1 - 0.25 11.3 5.8 0.43 10.5 5.8 1.4 1 0 0 1 1 1 0 PHD-finger FANCL_C PF11793.8 EXF76398.1 - 0.46 10.7 3.2 1.2 9.4 3.2 1.7 1 1 0 1 1 1 0 FANCL C-terminal domain Zn_ribbon_17 PF17120.5 EXF76398.1 - 0.62 9.7 4.8 1.1 9.0 4.8 1.3 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-UDP PF14569.6 EXF76398.1 - 0.75 10.0 4.4 0.75 10.0 0.6 2.4 2 0 0 2 2 2 0 Zinc-binding RING-finger OAD_gamma PF04277.13 EXF76398.1 - 1 10.0 0.0 1 10.0 0.0 3.2 3 1 0 3 3 2 0 Oxaloacetate decarboxylase, gamma chain zf-C3HC4_4 PF15227.6 EXF76398.1 - 1.1 9.4 4.7 2.4 8.4 4.7 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING DUF3752 PF12572.8 EXF76399.1 - 4e-51 173.5 10.0 8.1e-51 172.5 10.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3752) Vps8 PF12816.7 EXF76400.1 - 2.3e-75 252.5 0.1 4.2e-75 251.6 0.1 1.5 1 0 0 1 1 1 1 Golgi CORVET complex core vacuolar protein 8 Clathrin PF00637.20 EXF76400.1 - 2.6e-05 24.1 0.0 0.12 12.3 0.0 3.0 2 0 0 2 2 2 2 Region in Clathrin and VPS zf-RING_5 PF14634.6 EXF76400.1 - 0.0081 16.1 0.0 0.0081 16.1 0.0 2.1 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EXF76400.1 - 0.032 14.3 0.2 0.077 13.0 0.2 1.7 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_11 PF17123.5 EXF76400.1 - 0.064 13.0 0.1 0.13 12.0 0.1 1.5 1 0 0 1 1 1 0 RING-like zinc finger zf-rbx1 PF12678.7 EXF76400.1 - 0.08 13.2 0.0 0.2 12.0 0.0 1.7 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-C3H2C3 PF17122.5 EXF76400.1 - 0.12 12.4 0.2 0.3 11.2 0.2 1.6 1 0 0 1 1 1 0 Zinc-finger zf-RING_2 PF13639.6 EXF76400.1 - 1.6 9.2 4.5 0.23 11.8 0.1 1.9 2 0 0 2 2 2 0 Ring finger domain PHD PF00628.29 EXF76400.1 - 6.9 6.7 6.0 0.97 9.4 0.3 2.4 2 0 0 2 2 2 0 PHD-finger RhgB_N PF09284.10 EXF76401.1 - 1.1e-84 283.9 1.1 1.6e-84 283.4 1.1 1.2 1 0 0 1 1 1 1 Rhamnogalacturonan lyase B, N-terminal CBM-like PF14683.6 EXF76401.1 - 4.2e-33 114.5 2.2 8.1e-33 113.6 0.1 2.5 3 1 0 3 3 3 1 Polysaccharide lyase family 4, domain III fn3_3 PF14686.6 EXF76401.1 - 1.3e-17 63.3 4.1 3.7e-17 61.9 4.1 1.8 1 0 0 1 1 1 1 Polysaccharide lyase family 4, domain II CarboxypepD_reg PF13620.6 EXF76401.1 - 0.00087 19.5 1.8 0.0013 19.0 0.5 2.0 2 0 0 2 2 2 1 Carboxypeptidase regulatory-like domain Cupin_5 PF06172.11 EXF76401.1 - 0.14 12.3 0.0 0.24 11.5 0.0 1.4 1 0 0 1 1 1 0 Cupin superfamily (DUF985) UDG PF03167.19 EXF76402.1 - 8.7e-13 48.5 0.0 1.3e-12 48.0 0.0 1.1 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily LigB PF02900.18 EXF76403.1 - 1.2e-27 96.7 0.0 1.4e-27 96.5 0.0 1.0 1 0 0 1 1 1 1 Catalytic LigB subunit of aromatic ring-opening dioxygenase TPR_11 PF13414.6 EXF76403.1 - 0.1 12.3 0.0 0.23 11.2 0.0 1.6 1 0 0 1 1 1 0 TPR repeat Tudor_3 PF18115.1 EXF76403.1 - 0.12 12.2 0.1 20 5.1 0.2 2.4 2 0 0 2 2 2 0 DNA repair protein Crb2 Tudor domain Peptidase_S8 PF00082.22 EXF76404.1 - 4.6e-37 127.9 9.5 9e-37 126.9 9.5 1.4 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 EXF76404.1 - 9.9e-22 77.4 0.5 2.6e-21 76.1 0.5 1.8 1 0 0 1 1 1 1 Peptidase inhibitor I9 Beach PF02138.18 EXF76405.1 - 9e-120 399.2 0.0 1.5e-119 398.5 0.0 1.4 1 0 0 1 1 1 1 Beige/BEACH domain Laminin_G_3 PF13385.6 EXF76405.1 - 6.6e-11 42.6 0.0 1.4e-10 41.6 0.0 1.5 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily PH_BEACH PF14844.6 EXF76405.1 - 3.4e-10 39.9 0.0 8.1e-10 38.7 0.0 1.6 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH WD40 PF00400.32 EXF76405.1 - 0.00027 21.6 4.1 0.14 13.1 0.1 4.7 4 0 0 4 4 4 1 WD domain, G-beta repeat DUF4800 PF16057.5 EXF76405.1 - 0.11 11.8 0.1 0.26 10.5 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4800) Inhibitor_I71 PF12628.7 EXF76406.1 - 0.022 14.6 0.0 0.023 14.6 0.0 1.1 1 0 0 1 1 1 0 Falstatin, cysteine peptidase inhibitor DDOST_48kD PF03345.14 EXF76407.1 - 5.5e-168 559.1 0.0 6.4e-168 558.9 0.0 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase 48 kDa subunit beta NAPRTase_C PF17956.1 EXF76407.1 - 0.11 12.9 0.0 0.23 11.9 0.0 1.6 1 0 0 1 1 1 0 Nicotinate phosphoribosyltransferase C-terminal domain ABC_membrane PF00664.23 EXF76409.1 - 8e-40 137.2 10.5 1.1e-39 136.7 10.5 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 EXF76409.1 - 8.5e-40 136.4 0.0 1.3e-30 106.7 0.0 2.5 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EXF76409.1 - 1.2e-07 31.4 0.3 0.011 15.2 0.0 3.2 2 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 EXF76409.1 - 0.00035 21.0 0.1 0.0019 18.6 0.1 2.2 2 0 0 2 2 2 1 AAA ATPase domain DUF3147 PF11345.8 EXF76409.1 - 0.00062 20.1 2.2 0.00084 19.7 0.6 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF3147) AAA_22 PF13401.6 EXF76409.1 - 0.00069 19.9 0.0 0.0034 17.7 0.0 2.4 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 EXF76409.1 - 0.0052 16.5 0.0 0.013 15.2 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.6 EXF76409.1 - 0.0064 16.2 0.0 0.011 15.5 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain ABC_ATPase PF09818.9 EXF76409.1 - 0.0067 15.3 0.0 0.32 9.7 0.0 2.5 3 0 0 3 3 3 1 Predicted ATPase of the ABC class AAA PF00004.29 EXF76409.1 - 0.0074 16.7 1.5 0.13 12.7 1.5 2.7 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 EXF76409.1 - 0.0097 15.8 0.0 0.024 14.6 0.0 1.6 1 0 0 1 1 1 1 RsgA GTPase AAA_30 PF13604.6 EXF76409.1 - 0.02 14.6 0.2 0.21 11.3 0.2 2.5 1 1 1 2 2 2 0 AAA domain SbcCD_C PF13558.6 EXF76409.1 - 0.026 14.8 0.0 3.3 8.0 0.0 2.8 2 0 0 2 2 2 0 Putative exonuclease SbcCD, C subunit Zeta_toxin PF06414.12 EXF76409.1 - 0.043 13.1 0.0 0.14 11.4 0.0 1.8 1 0 0 1 1 1 0 Zeta toxin IPK PF03770.16 EXF76409.1 - 0.16 11.9 0.0 0.71 9.7 0.0 1.8 1 1 0 1 1 1 0 Inositol polyphosphate kinase Rad17 PF03215.15 EXF76409.1 - 0.18 11.7 0.0 0.38 10.6 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain adh_short_C2 PF13561.6 EXF76410.1 - 2.1e-32 112.6 0.9 2.8e-32 112.2 0.9 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF76410.1 - 4.1e-22 78.6 0.2 5.8e-22 78.1 0.2 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EXF76410.1 - 4.5e-05 23.4 0.3 0.00017 21.5 0.1 1.8 2 0 0 2 2 2 1 KR domain NAD_binding_7 PF13241.6 EXF76410.1 - 0.0099 16.3 0.1 0.04 14.4 0.0 1.9 2 1 0 2 2 2 1 Putative NAD(P)-binding Eno-Rase_NADH_b PF12242.8 EXF76410.1 - 0.013 15.3 1.1 0.024 14.4 1.1 1.5 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase THF_DHG_CYH_C PF02882.19 EXF76410.1 - 0.028 13.7 1.0 0.076 12.3 0.1 2.2 3 0 0 3 3 3 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain B277 PF17623.2 EXF76410.1 - 0.036 13.1 0.9 0.067 12.3 0.9 1.4 1 0 0 1 1 1 0 Domain of unknown function Abhydrolase_6 PF12697.7 EXF76412.1 - 5.9e-11 43.4 0.0 7.1e-11 43.1 0.0 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EXF76412.1 - 0.0046 16.6 0.0 0.43 10.2 0.0 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold ADH_zinc_N PF00107.26 EXF76413.1 - 6.6e-12 45.5 0.0 9.6e-12 45.0 0.0 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EXF76413.1 - 2.3e-07 31.9 0.0 3.6e-07 31.3 0.0 1.3 1 1 0 1 1 1 1 Zinc-binding dehydrogenase DapB_N PF01113.20 EXF76413.1 - 0.031 14.4 0.3 0.044 13.9 0.3 1.3 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Epimerase PF01370.21 EXF76413.1 - 0.12 11.8 0.1 0.13 11.7 0.1 1.1 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Ldh_1_N PF00056.23 EXF76413.1 - 0.14 12.3 0.9 0.99 9.5 0.1 2.1 2 0 0 2 2 2 0 lactate/malate dehydrogenase, NAD binding domain RmlD_sub_bind PF04321.17 EXF76413.1 - 0.21 10.7 0.1 0.27 10.3 0.1 1.1 1 0 0 1 1 1 0 RmlD substrate binding domain Abhydrolase_1 PF00561.20 EXF76415.1 - 3.1e-46 158.1 0.0 1.2e-45 156.2 0.0 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Esterase PF00756.20 EXF76415.1 - 0.0017 18.0 0.0 0.0028 17.3 0.0 1.3 1 0 0 1 1 1 1 Putative esterase zf-RING_6 PF14835.6 EXF76415.1 - 0.036 13.9 0.2 0.093 12.6 0.2 1.6 1 0 0 1 1 1 0 zf-RING of BARD1-type protein NUDIX PF00293.28 EXF76416.1 - 1.3e-07 31.7 0.0 2.3e-07 30.9 0.0 1.4 1 1 0 1 1 1 1 NUDIX domain NUDIX PF00293.28 EXF76417.1 - 6.1e-16 58.7 0.1 1e-15 58.0 0.1 1.3 1 0 0 1 1 1 1 NUDIX domain SIR2 PF02146.17 EXF76418.1 - 4.6e-57 192.8 0.0 6.6e-57 192.3 0.0 1.3 1 0 0 1 1 1 1 Sir2 family MFS_1 PF07690.16 EXF76418.1 - 3.9e-16 58.9 29.9 4e-16 58.9 25.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily FapA PF03961.13 EXF76418.1 - 0.025 13.2 0.5 0.046 12.3 0.5 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF4524 PF15025.6 EXF76419.1 - 0.05 13.3 0.1 0.064 13.0 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4524) FAD_binding_3 PF01494.19 EXF76420.1 - 3e-27 95.8 0.0 1e-26 94.0 0.0 1.7 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EXF76420.1 - 8.3e-07 28.5 0.7 0.00055 19.2 0.1 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EXF76420.1 - 1.6e-05 24.2 1.0 0.00025 20.2 1.0 2.1 1 1 0 1 1 1 1 Lycopene cyclase protein DAO PF01266.24 EXF76420.1 - 0.00015 21.5 0.0 0.00025 20.7 0.0 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EXF76420.1 - 0.00057 19.2 0.7 0.017 14.4 0.3 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EXF76420.1 - 0.0015 18.7 0.5 0.004 17.3 0.5 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 EXF76420.1 - 0.0064 15.8 0.5 0.4 9.9 0.0 2.4 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase Pyr_redox PF00070.27 EXF76420.1 - 0.0067 17.0 2.1 0.0092 16.5 0.5 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EXF76420.1 - 0.022 13.9 0.1 0.045 12.8 0.1 1.5 1 1 0 1 1 1 0 Glucose inhibited division protein A FAD_binding_2 PF00890.24 EXF76420.1 - 0.024 13.7 1.3 0.083 12.0 0.6 2.0 2 0 0 2 2 2 0 FAD binding domain Trp_halogenase PF04820.14 EXF76420.1 - 0.042 12.7 0.6 0.29 9.9 0.2 2.1 2 0 0 2 2 2 0 Tryptophan halogenase FAA_hydrolase PF01557.18 EXF76421.1 - 3e-64 216.7 0.0 4.5e-64 216.1 0.0 1.3 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family p450 PF00067.22 EXF76421.1 - 9e-59 199.4 0.0 1.3e-58 198.9 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Abhydrolase_1 PF00561.20 EXF76421.1 - 4.6e-19 69.1 0.3 1.4e-12 47.8 0.0 2.8 3 0 0 3 3 3 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EXF76421.1 - 6.6e-17 61.6 0.0 2e-16 60.0 0.0 1.7 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EXF76421.1 - 6.7e-17 62.8 2.2 1.1e-16 62.1 0.2 2.3 3 0 0 3 3 3 1 Alpha/beta hydrolase family Ser_hydrolase PF06821.13 EXF76421.1 - 2.3e-09 37.3 0.1 0.00045 20.1 0.0 2.6 1 1 1 2 2 2 2 Serine hydrolase Abhydrolase_4 PF08386.10 EXF76421.1 - 0.18 12.0 0.0 0.42 10.7 0.0 1.6 1 0 0 1 1 1 0 TAP-like protein Amidohydro_1 PF01979.20 EXF76422.1 - 7.3e-20 71.6 0.0 7.3e-19 68.3 0.0 2.3 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EXF76422.1 - 8.3e-16 58.5 0.8 1e-10 41.7 0.2 2.7 2 1 0 2 2 2 2 Amidohydrolase family F-box-like PF12937.7 EXF76424.1 - 0.028 14.3 0.1 0.23 11.4 0.1 2.3 2 0 0 2 2 2 0 F-box-like PCIF1_WW PF12237.8 EXF76424.1 - 0.05 13.2 0.1 0.085 12.5 0.1 1.3 1 0 0 1 1 1 0 Phosphorylated CTD interacting factor 1 WW domain Amidase PF01425.21 EXF76425.1 - 1.7e-117 393.1 0.1 2.4e-117 392.7 0.1 1.2 1 0 0 1 1 1 1 Amidase PRP38 PF03371.15 EXF76426.1 - 5.9e-54 182.6 0.0 7.2e-54 182.3 0.0 1.1 1 0 0 1 1 1 1 PRP38 family CBFD_NFYB_HMF PF00808.23 EXF76428.1 - 1.7e-17 63.4 1.5 3e-17 62.6 0.7 1.8 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EXF76428.1 - 1.9e-05 25.0 0.4 8.4e-05 22.9 0.0 1.9 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 BBIP10 PF14777.6 EXF76428.1 - 0.044 13.4 1.2 0.23 11.0 0.1 2.5 2 1 0 2 2 2 0 Cilia BBSome complex subunit 10 DUF3656 PF12392.8 EXF76428.1 - 0.078 13.6 0.8 0.13 12.9 0.8 1.4 1 1 0 1 1 1 0 Collagenase Bromo_TP PF07524.13 EXF76428.1 - 0.092 12.8 0.1 0.2 11.7 0.1 1.6 1 1 0 1 1 1 0 Bromodomain associated adh_short PF00106.25 EXF76429.1 - 2.5e-42 144.5 0.4 3e-42 144.3 0.4 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF76429.1 - 1.2e-31 110.1 0.5 1.4e-31 109.9 0.5 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF76429.1 - 1.8e-10 41.0 0.3 2.3e-10 40.7 0.3 1.1 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 EXF76429.1 - 2.3e-06 27.7 0.1 4.4e-06 26.7 0.1 1.5 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EXF76429.1 - 0.0015 18.0 0.1 0.0047 16.4 0.0 1.8 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 EXF76429.1 - 0.0077 15.8 0.3 0.013 15.1 0.3 1.3 1 0 0 1 1 1 1 NmrA-like family Flot PF15975.5 EXF76429.1 - 0.015 15.5 0.1 0.029 14.6 0.1 1.6 1 1 1 2 2 2 0 Flotillin Shikimate_DH PF01488.20 EXF76429.1 - 0.076 13.1 0.1 0.15 12.1 0.1 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase DAO PF01266.24 EXF76430.1 - 3.8e-48 164.9 0.9 4.4e-48 164.7 0.9 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 EXF76430.1 - 1.4e-05 25.5 0.0 0.041 14.4 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EXF76430.1 - 0.0023 17.2 0.0 1 8.5 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EXF76430.1 - 0.0046 16.1 0.0 0.032 13.3 0.0 2.2 3 0 0 3 3 3 1 Lycopene cyclase protein NAD_binding_8 PF13450.6 EXF76430.1 - 0.008 16.4 0.2 0.008 16.4 0.2 2.5 4 0 0 4 4 4 1 NAD(P)-binding Rossmann-like domain DUF3203 PF11462.8 EXF76430.1 - 0.013 15.7 0.8 1.1 9.5 0.1 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF3203) Sacchrp_dh_NADP PF03435.18 EXF76430.1 - 0.05 13.9 0.0 0.092 13.0 0.0 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain HI0933_like PF03486.14 EXF76430.1 - 0.069 11.8 0.0 0.13 10.9 0.0 1.4 1 0 0 1 1 1 0 HI0933-like protein ApbA PF02558.16 EXF76430.1 - 0.13 11.9 0.0 0.22 11.1 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA FAD_binding_3 PF01494.19 EXF76430.1 - 0.15 11.3 0.0 2.6 7.2 0.0 2.1 2 0 0 2 2 2 0 FAD binding domain CBM_1 PF00734.18 EXF76432.1 - 1.3e-12 47.5 10.3 4.1e-12 45.8 10.3 2.0 1 0 0 1 1 1 1 Fungal cellulose binding domain Toxin_7 PF05980.12 EXF76432.1 - 0.042 14.1 2.8 0.08 13.2 2.8 1.5 1 0 0 1 1 1 0 Toxin 7 Zincin_1 PF06262.11 EXF76432.1 - 0.17 12.0 0.1 0.51 10.5 0.1 1.7 1 0 0 1 1 1 0 Zincin-like metallopeptidase Peptidase_M66 PF10462.9 EXF76432.1 - 0.39 9.6 3.8 0.2 10.5 0.4 2.0 2 0 0 2 2 2 0 Peptidase M66 Peptidase_M57 PF12388.8 EXF76432.1 - 0.56 9.8 0.1 0.56 9.8 0.1 2.3 3 0 0 3 3 3 0 Dual-action HEIGH metallo-peptidase Mito_fiss_reg PF05308.11 EXF76432.1 - 8.4 6.4 6.7 14 5.7 6.7 1.3 1 0 0 1 1 1 0 Mitochondrial fission regulator p450 PF00067.22 EXF76434.1 - 4e-23 81.9 0.0 3.1e-16 59.2 0.0 3.0 1 1 1 2 2 2 2 Cytochrome P450 FluMu_N PF17891.1 EXF76434.1 - 0.1 12.4 0.1 0.25 11.1 0.1 1.6 1 0 0 1 1 1 0 Mu-like prophage FluMu N-terminal domain DNA_pol_phi PF04931.13 EXF76434.1 - 0.22 9.6 0.0 0.3 9.2 0.0 1.1 1 0 0 1 1 1 0 DNA polymerase phi Ribosomal_S26e PF01283.19 EXF76435.1 - 2.6e-52 175.8 9.1 3e-52 175.6 9.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S26e zf_CopZ PF18423.1 EXF76435.1 - 0.012 15.5 0.4 0.052 13.5 0.0 2.0 2 0 0 2 2 2 0 Zinc binding domain DUF4668 PF15701.5 EXF76435.1 - 0.24 11.2 2.5 0.23 11.3 1.5 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4668) Adenylsucc_synt PF00709.21 EXF76436.1 - 7.1e-165 549.0 0.0 1e-164 548.5 0.0 1.2 1 0 0 1 1 1 1 Adenylosuccinate synthetase CFEM PF05730.11 EXF76437.1 - 7.4e-09 35.6 7.3 2e-08 34.2 7.3 1.7 1 0 0 1 1 1 1 CFEM domain Methyltrans_Mon PF14314.6 EXF76438.1 - 0.13 10.2 0.0 0.17 9.9 0.0 1.0 1 0 0 1 1 1 0 Virus-capping methyltransferase Sugar_tr PF00083.24 EXF76439.1 - 1.4e-101 340.6 17.4 1.6e-101 340.5 17.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF76439.1 - 1.2e-15 57.4 26.3 1.2e-15 57.4 26.3 2.3 1 1 0 2 2 2 2 Major Facilitator Superfamily Phage_holin_3_2 PF04550.12 EXF76439.1 - 0.005 17.3 0.6 0.019 15.5 0.6 2.0 1 0 0 1 1 1 1 Phage holin family 2 adh_short_C2 PF13561.6 EXF76440.1 - 1e-56 192.1 3.6 1.3e-56 191.8 3.6 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF76440.1 - 3.5e-43 147.3 3.3 4.4e-43 147.0 3.3 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EXF76440.1 - 2.3e-11 43.9 3.0 3.3e-11 43.4 3.0 1.1 1 0 0 1 1 1 1 KR domain DUF2188 PF09954.9 EXF76440.1 - 0.1 12.7 2.6 0.16 12.2 0.3 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2188) Melibiase_2 PF16499.5 EXF76441.1 - 2.2e-37 128.8 0.7 4.7e-37 127.7 0.7 1.6 1 1 0 1 1 1 1 Alpha galactosidase A Melibiase_C PF17801.1 EXF76441.1 - 1.8e-15 56.8 3.0 2.2e-15 56.5 1.4 2.1 2 0 0 2 2 2 1 Alpha galactosidase C-terminal beta sandwich domain Melibiase PF02065.18 EXF76441.1 - 0.00096 18.2 0.0 0.0017 17.3 0.0 1.3 1 0 0 1 1 1 1 Melibiase Glyco_hydro_61 PF03443.14 EXF76442.1 - 9.2e-59 198.8 0.1 1.1e-58 198.6 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 Spore_SspJ PF09575.10 EXF76444.1 - 0.044 14.1 0.0 0.12 12.8 0.0 1.6 1 0 0 1 1 1 0 Small spore protein J (Spore_SspJ) ADH_N PF08240.12 EXF76448.1 - 2.7e-27 94.8 0.4 4.5e-27 94.1 0.4 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EXF76448.1 - 1.8e-23 83.0 0.2 2.8e-23 82.3 0.2 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EXF76448.1 - 3e-08 33.4 1.6 5.7e-08 32.5 1.6 1.5 1 1 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 EXF76448.1 - 9.6e-07 29.9 0.0 2.1e-06 28.8 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase FAD_binding_3 PF01494.19 EXF76448.1 - 7.4e-05 22.1 0.1 9.9e-05 21.7 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.6 EXF76448.1 - 0.0084 15.4 0.2 0.012 14.9 0.2 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Shikimate_DH PF01488.20 EXF76448.1 - 0.013 15.6 0.2 0.022 14.8 0.2 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase AIRS PF00586.24 EXF76448.1 - 0.027 15.1 0.2 0.072 13.7 0.2 1.7 1 0 0 1 1 1 0 AIR synthase related protein, N-terminal domain ADH_N_assoc PF13823.6 EXF76448.1 - 0.031 14.2 0.0 0.074 13.0 0.0 1.7 1 0 0 1 1 1 0 Alcohol dehydrogenase GroES-associated AlaDh_PNT_C PF01262.21 EXF76448.1 - 0.031 13.6 4.1 0.046 13.0 4.1 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Peptidase_S8 PF00082.22 EXF76450.1 - 2.5e-25 89.3 2.9 6.9e-25 87.9 2.9 1.6 1 1 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 EXF76450.1 - 2.1e-09 37.9 0.0 4.3e-09 36.9 0.0 1.5 1 0 0 1 1 1 1 Peptidase inhibitor I9 Zn_clus PF00172.18 EXF76451.1 - 3.8e-09 36.5 12.8 6.8e-09 35.7 12.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EXF76451.1 - 3.5e-06 26.1 0.1 7.7e-06 25.0 0.1 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain NAP PF00956.18 EXF76452.1 - 2.9e-27 95.5 10.0 1.2e-26 93.6 0.1 2.4 2 1 1 3 3 3 2 Nucleosome assembly protein (NAP) Ribosomal_60s PF00428.19 EXF76452.1 - 5.3 7.7 24.4 7.7 7.2 11.1 2.9 2 1 0 2 2 2 0 60s Acidic ribosomal protein CENP-B_dimeris PF09026.10 EXF76452.1 - 8.6 6.8 19.0 9.7 6.6 2.3 2.3 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Kelch_5 PF13854.6 EXF76453.1 - 5.3e-09 35.9 0.2 5.3e-09 35.9 0.2 3.8 4 0 0 4 4 4 1 Kelch motif Gly-zipper_YMGG PF13441.6 EXF76453.1 - 0.013 15.3 1.6 0.04 13.7 1.6 1.8 1 0 0 1 1 1 0 YMGG-like Gly-zipper Kelch_6 PF13964.6 EXF76453.1 - 0.042 14.2 10.0 1.8 9.0 0.2 4.2 5 0 0 5 5 5 0 Kelch motif Kelch_4 PF13418.6 EXF76453.1 - 0.05 13.6 11.8 7.2 6.7 0.2 4.9 4 1 0 4 4 4 0 Galactose oxidase, central domain Polysacc_synt_C PF14667.6 EXF76453.1 - 0.093 12.8 0.0 0.16 12.0 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis C-terminal domain Kelch_3 PF13415.6 EXF76453.1 - 0.095 13.0 4.7 2.9 8.3 0.1 3.9 3 1 0 3 3 3 0 Galactose oxidase, central domain Gly-zipper_Omp PF13488.6 EXF76453.1 - 0.16 12.0 5.7 0.061 13.3 1.4 2.4 2 0 0 2 2 2 0 Glycine zipper EphA2_TM PF14575.6 EXF76453.1 - 0.19 12.6 0.0 0.36 11.8 0.0 1.4 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Rick_17kDa_Anti PF05433.15 EXF76453.1 - 0.32 10.9 7.6 0.092 12.6 3.8 2.1 2 0 0 2 2 2 0 Glycine zipper 2TM domain Kelch_2 PF07646.15 EXF76453.1 - 0.63 10.1 7.0 17 5.6 0.0 4.6 4 1 0 4 4 4 0 Kelch motif Kelch_1 PF01344.25 EXF76453.1 - 7.6 6.2 8.5 20 4.9 0.1 4.1 3 1 0 3 3 3 0 Kelch motif Questin_oxidase PF14027.6 EXF76454.1 - 1.4e-96 324.0 0.2 1.7e-96 323.7 0.2 1.1 1 0 0 1 1 1 1 Questin oxidase-like GP88 PF17338.2 EXF76454.1 - 0.025 14.0 0.0 0.053 13.0 0.0 1.4 1 0 0 1 1 1 0 Gene product 88 ACP_PD PF04336.12 EXF76454.1 - 0.042 14.3 0.3 0.042 14.3 0.3 2.0 2 0 0 2 2 2 0 Acyl carrier protein phosphodiesterase WD40 PF00400.32 EXF76455.1 - 1.9e-37 126.6 28.7 1.2e-08 35.4 0.0 12.3 14 0 0 14 14 14 7 WD domain, G-beta repeat Utp12 PF04003.12 EXF76455.1 - 5.4e-24 84.6 0.0 9.7e-24 83.7 0.0 1.4 1 0 0 1 1 1 1 Dip2/Utp12 Family ANAPC4_WD40 PF12894.7 EXF76455.1 - 5.4e-20 71.5 0.0 0.012 15.9 0.0 10.0 5 2 6 11 11 11 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EXF76455.1 - 1.3e-07 30.9 0.2 0.69 8.8 0.0 5.8 5 2 3 8 8 8 3 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 EXF76455.1 - 1.4e-05 25.0 5.8 0.056 13.3 0.2 5.9 6 1 1 7 7 7 2 Eukaryotic translation initiation factor eIF2A Nbas_N PF15492.6 EXF76455.1 - 0.0024 17.2 0.3 3.6 6.8 0.0 3.8 3 1 1 4 4 4 2 Neuroblastoma-amplified sequence, N terminal Cytochrom_D1 PF02239.16 EXF76455.1 - 0.041 12.4 0.1 1.7 7.1 0.0 3.3 1 1 1 3 3 3 0 Cytochrome D1 heme domain PD40 PF07676.12 EXF76455.1 - 0.046 13.7 0.2 30 4.7 0.0 4.3 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat Nup160 PF11715.8 EXF76455.1 - 0.064 11.9 4.2 5.8 5.4 0.0 3.7 3 2 1 4 4 4 0 Nucleoporin Nup120/160 Septin PF00735.18 EXF76456.1 - 6.9e-114 379.9 0.2 1e-113 379.3 0.2 1.3 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 EXF76456.1 - 2.6e-07 30.7 0.0 5.4e-07 29.7 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EXF76456.1 - 7.1e-06 26.0 1.6 3.1e-05 23.9 0.0 2.6 3 0 0 3 3 3 1 RsgA GTPase GTP_EFTU PF00009.27 EXF76456.1 - 1.2e-05 24.9 4.2 7.7e-05 22.3 0.1 2.8 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA_22 PF13401.6 EXF76456.1 - 0.002 18.4 0.8 0.0056 16.9 0.1 2.1 2 1 0 2 2 2 1 AAA domain Pox_A32 PF04665.12 EXF76456.1 - 0.0025 17.3 0.1 0.0052 16.3 0.1 1.5 1 0 0 1 1 1 1 Poxvirus A32 protein Roc PF08477.13 EXF76456.1 - 0.0035 17.5 0.1 0.0078 16.4 0.1 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AIG1 PF04548.16 EXF76456.1 - 0.0071 15.7 0.0 0.015 14.6 0.0 1.5 1 0 0 1 1 1 1 AIG1 family IIGP PF05049.13 EXF76456.1 - 0.0089 15.1 0.0 0.016 14.3 0.0 1.4 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) Casc1_N PF15927.5 EXF76456.1 - 0.012 15.3 11.4 0.03 14.0 11.4 1.6 1 0 0 1 1 1 0 Cancer susceptibility candidate 1 N-terminus AAA_24 PF13479.6 EXF76456.1 - 0.013 15.3 0.0 0.027 14.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain Ras PF00071.22 EXF76456.1 - 0.02 14.5 0.5 0.062 12.9 0.5 1.8 1 1 0 1 1 1 0 Ras family KAP_NTPase PF07693.14 EXF76456.1 - 0.028 13.7 0.0 0.04 13.1 0.0 1.6 1 1 0 1 1 1 0 KAP family P-loop domain AAA_16 PF13191.6 EXF76456.1 - 0.035 14.5 1.1 0.095 13.1 0.0 2.2 2 1 0 2 2 2 0 AAA ATPase domain T2SSE PF00437.20 EXF76456.1 - 0.045 12.8 0.5 0.18 10.9 0.0 2.0 2 0 0 2 2 2 0 Type II/IV secretion system protein NACHT PF05729.12 EXF76456.1 - 0.048 13.6 0.0 0.099 12.6 0.0 1.5 1 0 0 1 1 1 0 NACHT domain ABC_tran PF00005.27 EXF76456.1 - 0.053 14.0 0.3 0.2 12.2 0.0 2.0 2 0 0 2 2 2 0 ABC transporter FOXP-CC PF16159.5 EXF76456.1 - 0.066 13.8 1.2 0.066 13.8 1.2 2.5 2 1 1 3 3 2 0 FOXP coiled-coil domain AAA_25 PF13481.6 EXF76456.1 - 0.072 12.7 0.3 0.27 10.8 0.0 2.0 2 0 0 2 2 2 0 AAA domain Sigma54_activat PF00158.26 EXF76456.1 - 0.081 12.6 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain PduV-EutP PF10662.9 EXF76456.1 - 0.13 12.0 0.4 8.3 6.2 0.1 2.7 1 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation RNA_helicase PF00910.22 EXF76456.1 - 0.14 12.5 0.0 0.43 11.0 0.0 1.9 2 0 0 2 2 1 0 RNA helicase Dynamin_N PF00350.23 EXF76456.1 - 0.54 10.3 7.3 4.2 7.4 0.1 3.1 2 1 1 3 3 3 0 Dynamin family FUSC PF04632.12 EXF76456.1 - 3.2 6.2 4.6 4.4 5.7 4.6 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family AAA_11 PF13086.6 EXF76456.1 - 3.8 7.2 7.5 23 4.7 0.1 2.2 2 0 0 2 2 2 0 AAA domain Myc-LZ PF02344.15 EXF76456.1 - 4.3 7.5 9.1 5.2 7.3 3.1 3.2 2 1 0 2 2 2 0 Myc leucine zipper domain BCDHK_Adom3 PF10436.9 EXF76457.1 - 5.9e-48 162.8 0.1 1.2e-47 161.8 0.1 1.5 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 EXF76457.1 - 5.7e-07 30.0 0.0 2.7e-06 27.9 0.0 2.1 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 EXF76457.1 - 0.0065 16.3 0.0 0.014 15.3 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase USP7_ICP0_bdg PF12436.8 EXF76458.1 - 1.9e-87 292.6 0.1 5.9e-86 287.7 0.1 2.3 2 0 0 2 2 2 1 ICP0-binding domain of Ubiquitin-specific protease 7 USP7_C2 PF14533.6 EXF76458.1 - 1.5e-80 269.8 2.7 3.7e-75 252.1 3.0 4.0 3 1 0 3 3 3 2 Ubiquitin-specific protease C-terminal UCH PF00443.29 EXF76458.1 - 6.7e-47 160.1 2.6 1e-46 159.5 2.6 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EXF76458.1 - 1e-19 71.3 0.2 2.5e-19 70.0 0.2 1.7 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase MATH PF00917.26 EXF76458.1 - 7.7e-11 42.2 0.1 6.8e-10 39.1 0.0 2.6 2 1 1 3 3 3 1 MATH domain YukD PF08817.10 EXF76458.1 - 0.19 12.5 0.0 4.2 8.1 0.0 2.6 2 0 0 2 2 2 0 WXG100 protein secretion system (Wss), protein YukD Tim17 PF02466.19 EXF76459.1 - 2.5e-39 134.1 8.8 3.2e-39 133.7 8.8 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family DUF543 PF04418.12 EXF76459.1 - 0.036 14.1 0.3 0.49 10.4 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF543) zf-HIT PF04438.16 EXF76460.1 - 0.2 11.6 0.3 0.39 10.6 0.3 1.4 1 0 0 1 1 1 0 HIT zinc finger Mobilization_B PF17511.2 EXF76460.1 - 0.31 11.4 1.4 0.7 10.3 1.4 1.5 1 0 0 1 1 1 0 Mobilization protein B SKIP_SNW PF02731.15 EXF76461.1 - 8.2e-72 240.1 5.3 8.2e-72 240.1 5.3 2.7 3 0 0 3 3 3 1 SKIP/SNW domain Nucleo_P87 PF07267.11 EXF76461.1 - 4.4 6.0 9.6 9.7 4.9 9.6 1.6 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 HET PF06985.11 EXF76462.1 - 9.7e-07 29.2 1.7 0.0028 18.0 0.1 2.7 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) FAD_binding_4 PF01565.23 EXF76463.1 - 2.3e-24 85.7 1.3 5e-24 84.6 1.3 1.6 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EXF76463.1 - 3.1e-06 27.2 0.3 6.6e-06 26.1 0.3 1.6 1 0 0 1 1 1 1 Berberine and berberine like DUF2721 PF11026.8 EXF76464.1 - 7.1 6.5 11.2 3.3 7.6 4.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) RmlD_sub_bind PF04321.17 EXF76465.1 - 1.8e-54 184.8 0.0 2.1e-54 184.6 0.0 1.0 1 0 0 1 1 1 1 RmlD substrate binding domain Epimerase PF01370.21 EXF76465.1 - 1.4e-20 73.8 0.0 1.8e-20 73.5 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 EXF76465.1 - 2.6e-11 43.2 0.0 1.4e-09 37.5 0.0 2.2 2 0 0 2 2 2 1 Male sterility protein GDP_Man_Dehyd PF16363.5 EXF76465.1 - 9.9e-10 38.3 0.0 2.1e-09 37.3 0.0 1.5 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 EXF76465.1 - 3.9e-07 29.4 0.0 1.3e-06 27.7 0.0 1.7 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 EXF76465.1 - 1.3e-06 27.8 0.3 0.00017 20.8 0.0 2.9 1 1 1 2 2 2 1 Polysaccharide biosynthesis protein KR PF08659.10 EXF76465.1 - 0.11 12.5 0.7 17 5.3 0.1 2.4 1 1 1 2 2 2 0 KR domain PH PF00169.29 EXF76466.1 - 0.00072 20.0 0.3 0.0014 19.1 0.3 1.4 1 0 0 1 1 1 1 PH domain CSN5_C PF18323.1 EXF76466.1 - 6.6 7.7 6.5 1.1e+02 3.8 4.4 2.9 2 0 0 2 2 2 0 Cop9 signalosome subunit 5 C-terminal domain polyprenyl_synt PF00348.17 EXF76467.1 - 3.5e-90 301.5 0.0 4.6e-90 301.1 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase ANAPC8 PF04049.13 EXF76468.1 - 2e-46 157.5 1.3 3.1e-46 156.9 0.1 1.9 2 0 0 2 2 2 1 Anaphase promoting complex subunit 8 / Cdc23 TPR_8 PF13181.6 EXF76468.1 - 6.4e-24 82.1 7.1 6.8e-05 22.8 0.0 7.3 7 0 0 7 7 6 4 Tetratricopeptide repeat TPR_1 PF00515.28 EXF76468.1 - 5.3e-23 79.8 1.5 0.00036 20.2 0.0 7.7 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_2 PF07719.17 EXF76468.1 - 6.9e-17 60.1 15.1 0.075 13.2 0.0 8.8 9 0 0 9 9 8 6 Tetratricopeptide repeat TPR_14 PF13428.6 EXF76468.1 - 5.4e-11 42.4 13.3 0.0056 17.4 0.1 8.2 7 2 1 8 8 7 2 Tetratricopeptide repeat TPR_16 PF13432.6 EXF76468.1 - 1e-08 35.7 1.3 2.4e-05 24.9 0.0 5.7 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_11 PF13414.6 EXF76468.1 - 2.5e-08 33.4 1.0 1.1e-06 28.2 0.1 3.4 4 0 0 4 4 4 1 TPR repeat TPR_12 PF13424.6 EXF76468.1 - 1e-06 28.9 16.7 0.5 10.7 0.1 7.3 6 1 1 7 7 7 3 Tetratricopeptide repeat ANAPC3 PF12895.7 EXF76468.1 - 9.4e-06 25.8 6.0 0.073 13.3 0.3 5.4 4 1 2 6 6 6 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 EXF76468.1 - 0.00035 21.0 9.3 21 6.0 0.0 7.1 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_19 PF14559.6 EXF76468.1 - 0.0004 20.8 10.6 6 7.5 0.0 6.8 8 1 1 9 9 8 2 Tetratricopeptide repeat DUF3856 PF12968.7 EXF76468.1 - 0.0005 20.2 0.8 0.054 13.6 0.1 3.2 1 1 1 2 2 2 1 Domain of Unknown Function (DUF3856) TPR_7 PF13176.6 EXF76468.1 - 0.00051 19.9 9.2 0.2 11.8 0.0 5.7 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_9 PF13371.6 EXF76468.1 - 0.0022 18.1 9.1 2.2 8.5 0.3 5.1 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_17 PF13431.6 EXF76468.1 - 0.016 15.6 0.0 6.4 7.4 0.0 4.4 4 0 0 4 4 3 0 Tetratricopeptide repeat Say1_Mug180 PF10340.9 EXF76468.1 - 0.15 10.9 0.0 0.23 10.3 0.0 1.2 1 0 0 1 1 1 0 Steryl acetyl hydrolase TPR_10 PF13374.6 EXF76468.1 - 2 8.4 6.4 57 3.8 0.1 4.8 5 0 0 5 5 5 0 Tetratricopeptide repeat Sel1 PF08238.12 EXF76468.1 - 3.5 8.4 9.9 1.1e+02 3.7 0.0 5.5 6 0 0 6 6 5 0 Sel1 repeat Endostatin PF06482.11 EXF76469.1 - 8.5 5.7 6.5 11 5.4 6.5 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin G-alpha PF00503.20 EXF76471.1 - 3e-116 388.4 0.8 3.5e-116 388.2 0.8 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EXF76471.1 - 1.8e-15 56.8 0.4 5e-10 39.1 0.2 2.6 2 1 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EXF76471.1 - 0.0021 17.5 4.2 0.095 12.0 0.1 2.5 1 1 1 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.13 EXF76471.1 - 0.0038 17.4 0.5 1.3 9.3 0.1 2.6 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.6 EXF76471.1 - 0.1 12.4 0.0 0.22 11.3 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain GST_C PF00043.25 EXF76472.1 - 1e-12 48.0 0.1 2.1e-12 47.1 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EXF76472.1 - 1.9e-12 47.2 0.0 2.9e-12 46.6 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EXF76472.1 - 3.3e-08 33.4 0.5 6.6e-08 32.5 0.1 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EXF76472.1 - 2.6e-07 31.0 0.0 4.7e-07 30.1 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 EXF76472.1 - 6.1e-07 29.7 0.0 1.3e-06 28.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EXF76472.1 - 6.1e-05 23.2 0.0 0.00016 21.9 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Tom37 PF10568.9 EXF76472.1 - 0.19 12.0 0.0 0.3 11.4 0.0 1.3 1 0 0 1 1 1 0 Outer mitochondrial membrane transport complex protein AIM3 PF17096.5 EXF76473.1 - 0.02 15.8 5.6 0.02 15.8 5.6 2.3 2 0 0 2 2 2 0 Altered inheritance of mitochondria protein 3 FAM176 PF14851.6 EXF76473.1 - 0.095 12.4 5.2 0.13 11.9 0.2 2.1 2 0 0 2 2 2 0 FAM176 family TFB6 PF17110.5 EXF76473.1 - 0.15 11.8 4.5 0.45 10.2 0.4 2.0 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH PBP_sp32 PF07222.12 EXF76473.1 - 0.22 10.9 3.5 1.1 8.7 0.0 2.2 2 0 0 2 2 2 0 Proacrosin binding protein sp32 eIF3_subunit PF08597.10 EXF76473.1 - 1.2 9.0 23.8 0.031 14.2 6.4 2.1 2 0 0 2 2 2 0 Translation initiation factor eIF3 subunit U79_P34 PF03064.16 EXF76473.1 - 1.6 8.0 8.0 0.42 9.9 3.3 1.9 2 0 0 2 2 2 0 HSV U79 / HCMV P34 TLP-20 PF06088.11 EXF76473.1 - 3.9 7.3 8.4 0.5 10.2 2.3 2.0 2 0 0 2 2 2 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) Lon_C PF05362.13 EXF76474.1 - 5.2e-64 215.6 0.0 8.8e-64 214.8 0.0 1.4 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain LON_substr_bdg PF02190.16 EXF76474.1 - 7.6e-35 120.7 0.1 3.9e-34 118.4 0.1 2.2 1 1 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain AAA PF00004.29 EXF76474.1 - 7.2e-22 78.2 0.0 2.2e-21 76.6 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_2 PF07724.14 EXF76474.1 - 7.3e-07 29.5 0.0 3.5e-06 27.2 0.0 2.1 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 EXF76474.1 - 1.1e-06 28.7 0.0 3.1e-06 27.2 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) ChlI PF13541.6 EXF76474.1 - 1.3e-06 28.3 0.0 3.4e-06 26.9 0.0 1.7 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase AAA_22 PF13401.6 EXF76474.1 - 3e-05 24.3 0.0 0.00048 20.4 0.0 2.6 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.12 EXF76474.1 - 0.00015 21.6 0.0 0.00097 18.9 0.0 2.4 4 0 0 4 4 3 1 Holliday junction DNA helicase RuvB P-loop domain AAA_PrkA PF08298.11 EXF76474.1 - 0.00021 20.4 0.0 0.00039 19.5 0.0 1.4 1 0 0 1 1 1 1 PrkA AAA domain AAA_18 PF13238.6 EXF76474.1 - 0.00091 19.8 0.5 0.014 15.9 0.0 3.1 3 0 0 3 3 3 1 AAA domain AAA_16 PF13191.6 EXF76474.1 - 0.002 18.5 0.0 0.002 18.5 0.0 2.6 3 1 1 4 4 2 1 AAA ATPase domain IstB_IS21 PF01695.17 EXF76474.1 - 0.0053 16.5 0.7 0.053 13.2 0.0 2.6 3 0 0 3 3 3 1 IstB-like ATP binding protein AAA_14 PF13173.6 EXF76474.1 - 0.0055 16.7 0.0 0.03 14.4 0.0 2.2 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 EXF76474.1 - 0.03 14.7 0.0 0.1 13.0 0.0 2.0 1 0 0 1 1 1 0 RNA helicase RsgA_GTPase PF03193.16 EXF76474.1 - 0.036 14.0 0.0 0.11 12.4 0.0 1.8 1 0 0 1 1 1 0 RsgA GTPase AAA_28 PF13521.6 EXF76474.1 - 0.05 13.8 0.2 5 7.4 0.0 3.1 3 0 0 3 3 3 0 AAA domain DNTTIP1_dimer PF18192.1 EXF76474.1 - 0.05 14.0 0.2 1.3 9.4 0.0 3.0 2 1 0 2 2 2 0 DNTTIP1 dimerisation domain AAA_30 PF13604.6 EXF76474.1 - 0.051 13.3 0.0 0.14 11.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 EXF76474.1 - 0.062 13.2 0.3 1.2 9.1 0.0 2.6 1 1 1 2 2 2 0 NTPase AAA_7 PF12775.7 EXF76474.1 - 0.089 12.3 1.1 0.18 11.3 0.0 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region AbrB_C PF18277.1 EXF76474.1 - 0.089 12.4 0.1 0.65 9.7 0.1 2.5 2 0 0 2 2 2 0 AbrB C-terminal domain MMR_HSR1 PF01926.23 EXF76474.1 - 0.19 11.8 0.7 9 6.4 0.0 3.0 2 0 0 2 2 2 0 50S ribosome-binding GTPase ClpB_D2-small PF10431.9 EXF76474.1 - 0.55 10.3 5.2 0.21 11.6 0.5 2.5 2 0 0 2 2 2 0 C-terminal, D2-small domain, of ClpB protein ABC_tran PF00005.27 EXF76474.1 - 0.8 10.2 4.8 0.72 10.4 0.1 2.9 3 0 0 3 3 3 0 ABC transporter Pkinase PF00069.25 EXF76475.1 - 2.9e-12 46.5 0.0 2.2e-11 43.7 0.0 2.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF76475.1 - 1.1e-09 38.0 0.0 1.5e-08 34.3 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Catalase PF00199.19 EXF76476.1 - 1.9e-192 639.5 1.0 2.5e-192 639.1 1.0 1.0 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.12 EXF76476.1 - 4.1e-09 36.5 0.0 9.2e-09 35.4 0.0 1.6 1 0 0 1 1 1 1 Catalase-related immune-responsive Arf PF00025.21 EXF76477.1 - 6.6e-73 243.9 0.0 8.9e-73 243.4 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EXF76477.1 - 4.4e-14 52.7 0.0 7.7e-14 51.9 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EXF76477.1 - 7.2e-13 48.4 0.0 1e-12 47.9 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 EXF76477.1 - 3.7e-11 42.8 0.2 2.2e-07 30.4 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 EXF76477.1 - 3.1e-10 39.9 0.0 4.6e-10 39.3 0.0 1.2 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 EXF76477.1 - 8.5e-08 31.8 0.0 1.2e-07 31.3 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EXF76477.1 - 1.9e-06 27.9 0.1 5.4e-06 26.5 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EXF76477.1 - 0.0014 18.2 0.1 0.078 12.5 0.0 2.3 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain WRNPLPNID PF15017.6 EXF76477.1 - 0.0048 17.7 1.3 0.0048 17.7 1.3 1.8 2 0 0 2 2 2 1 Putative WW-binding domain and destruction box Ribosomal_60s PF00428.19 EXF76477.1 - 0.01 16.4 2.8 0.025 15.2 2.8 1.7 1 0 0 1 1 1 0 60s Acidic ribosomal protein FeoB_N PF02421.18 EXF76477.1 - 0.037 13.5 0.5 0.16 11.5 0.5 2.0 1 1 0 1 1 1 0 Ferrous iron transport protein B Ribosomal_L39 PF00832.20 EXF76478.1 - 6.3e-22 76.9 9.4 7.3e-22 76.7 9.4 1.1 1 0 0 1 1 1 1 Ribosomal L39 protein Skp1 PF01466.19 EXF76479.1 - 1.2e-29 102.2 0.4 3.4e-29 100.7 0.4 1.9 1 0 0 1 1 1 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.15 EXF76479.1 - 6.9e-21 74.2 0.3 1.7e-20 72.9 0.2 1.8 2 0 0 2 2 2 1 Skp1 family, tetramerisation domain LUD_dom PF02589.15 EXF76479.1 - 0.093 12.4 0.1 0.13 12.0 0.1 1.2 1 0 0 1 1 1 0 LUD domain Pkinase PF00069.25 EXF76481.1 - 4.6e-68 229.4 0.0 8.6e-68 228.5 0.0 1.4 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF76481.1 - 1.1e-49 169.0 0.0 1.9e-49 168.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Ras_bdg_2 PF14847.6 EXF76481.1 - 9.3e-27 93.3 0.0 1.8e-26 92.4 0.0 1.5 1 0 0 1 1 1 1 Ras-binding domain of Byr2 RA PF00788.23 EXF76481.1 - 7.2e-14 52.2 0.1 1.2e-13 51.5 0.1 1.3 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain Kinase-like PF14531.6 EXF76481.1 - 4.9e-07 29.4 0.0 0.0002 20.8 0.0 2.3 2 0 0 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 EXF76481.1 - 0.0064 15.3 0.0 0.012 14.4 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Abhydrolase_6 PF12697.7 EXF76482.1 - 1.2e-15 58.7 0.3 1.5e-15 58.4 0.3 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EXF76482.1 - 0.0012 18.6 0.0 0.16 11.6 0.0 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold DUF900 PF05990.12 EXF76482.1 - 0.085 12.4 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) Gate PF07670.14 EXF76483.1 - 0.098 12.9 3.0 0.42 10.9 3.0 2.1 1 1 0 1 1 1 0 Nucleoside recognition UPF0182 PF03699.13 EXF76483.1 - 0.33 9.0 6.3 0.6 8.2 6.3 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0182) SnoaL PF07366.12 EXF76484.1 - 4.3e-06 26.6 0.0 9.1e-06 25.5 0.0 1.6 1 0 0 1 1 1 1 SnoaL-like polyketide cyclase SnoaL_2 PF12680.7 EXF76484.1 - 0.00014 22.4 0.1 0.00028 21.5 0.1 1.5 1 0 0 1 1 1 1 SnoaL-like domain DLH PF01738.18 EXF76484.1 - 0.0011 18.5 0.0 0.0033 17.0 0.0 1.7 2 0 0 2 2 2 1 Dienelactone hydrolase family RgpF PF05045.12 EXF76485.1 - 0.006 15.4 0.1 0.022 13.5 0.0 1.8 2 0 0 2 2 2 1 Rhamnan synthesis protein F Apt1 PF10351.9 EXF76485.1 - 0.091 11.6 8.1 0.12 11.2 8.1 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain CCSAP PF15748.5 EXF76485.1 - 0.11 12.7 14.0 0.15 12.2 14.0 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Ndc1_Nup PF09531.10 EXF76485.1 - 1.1 7.9 8.3 1.4 7.6 8.3 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup VIR_N PF15912.5 EXF76485.1 - 6.8 6.2 9.5 10 5.6 9.5 1.2 1 0 0 1 1 1 0 Virilizer, N-terminal Macoilin PF09726.9 EXF76485.1 - 7.3 5.0 12.0 9.2 4.7 12.0 1.1 1 0 0 1 1 1 0 Macoilin family zf-C2H2 PF00096.26 EXF76489.1 - 0.0073 16.7 0.2 0.0073 16.7 0.2 1.9 2 1 1 3 3 3 1 Zinc finger, C2H2 type DUF1640 PF07798.11 EXF76490.1 - 8.2e-48 162.7 3.9 1.4e-47 161.9 3.9 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) PUF PF00806.19 EXF76491.1 - 1.1e-62 204.4 14.7 3.1e-08 32.9 0.1 8.3 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat SapB_2 PF03489.17 EXF76491.1 - 0.094 12.9 1.1 7.5 6.8 0.1 3.0 2 0 0 2 2 2 0 Saposin-like type B, region 2 TFIID_30kDa PF03540.13 EXF76491.1 - 0.13 12.2 0.0 0.37 10.8 0.0 1.7 1 0 0 1 1 1 0 Transcription initiation factor TFIID 23-30kDa subunit EphA2_TM PF14575.6 EXF76492.1 - 0.046 14.6 0.0 0.061 14.2 0.0 1.3 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain TMEM154 PF15102.6 EXF76492.1 - 0.052 13.4 0.0 0.079 12.9 0.0 1.3 1 0 0 1 1 1 0 TMEM154 protein family CD34_antigen PF06365.12 EXF76492.1 - 0.074 12.6 0.0 0.1 12.2 0.0 1.2 1 0 0 1 1 1 0 CD34/Podocalyxin family Sulfatase PF00884.23 EXF76493.1 - 3.8e-46 157.9 0.0 5.1e-46 157.5 0.0 1.2 1 0 0 1 1 1 1 Sulfatase DUF4976 PF16347.5 EXF76493.1 - 0.0014 18.8 0.0 0.0029 17.8 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4976) Phosphodiest PF01663.22 EXF76493.1 - 0.015 14.9 0.0 0.17 11.5 0.0 2.1 2 0 0 2 2 2 0 Type I phosphodiesterase / nucleotide pyrophosphatase DUF229 PF02995.17 EXF76493.1 - 0.029 13.0 0.0 0.036 12.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF229) SET PF00856.28 EXF76494.1 - 2e-09 38.1 0.1 2.3e-08 34.6 0.0 2.3 2 1 0 2 2 2 1 SET domain Inhibitor_I36 PF03995.13 EXF76494.1 - 0.11 12.4 0.2 0.36 10.8 0.0 1.9 2 0 0 2 2 2 0 Peptidase inhibitor family I36 F-box-like PF12937.7 EXF76495.1 - 0.043 13.7 0.2 0.16 11.9 0.2 2.0 1 0 0 1 1 1 0 F-box-like Kinetochor_Ybp2 PF08568.10 EXF76496.1 - 1.1e-93 314.8 0.0 1.4e-93 314.5 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family, YAP/Alf4/glomulin Glyco_transf_28 PF03033.20 EXF76497.1 - 2.4e-16 60.0 0.1 1.9e-15 57.1 0.1 2.3 1 1 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain UDPGT PF00201.18 EXF76497.1 - 1.2e-06 27.6 0.0 2.3e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase ATG_C PF09333.11 EXF76497.1 - 0.00028 21.2 0.0 0.0016 18.8 0.0 2.3 2 0 0 2 2 2 1 Autophagy-related protein C terminal domain Glyco_tran_28_C PF04101.16 EXF76497.1 - 0.0071 16.3 0.0 0.024 14.6 0.0 1.9 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Papilin_u7 PF16626.5 EXF76501.1 - 0.51 10.9 6.4 0.9 10.2 1.0 3.2 2 1 1 3 3 3 0 Linking region between Kunitz_BPTI and I-set on papilin zf-C2H2 PF00096.26 EXF76502.1 - 0.039 14.4 1.3 0.039 14.4 1.3 2.6 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EXF76502.1 - 0.13 13.1 1.7 0.13 13.1 1.7 2.4 2 1 1 3 3 3 0 C2H2-type zinc finger Zap1_zf2 PF18217.1 EXF76503.1 - 0.0038 17.2 0.9 0.0081 16.1 0.9 1.6 1 0 0 1 1 1 1 Zap1 zinc finger 2 Folliculin PF11704.8 EXF76504.1 - 4.6e-61 205.9 0.5 3.4e-60 203.1 0.0 2.3 2 1 0 2 2 2 1 Vesicle coat protein involved in Golgi to plasma membrane transport AAA PF00004.29 EXF76505.1 - 2.4e-45 154.2 0.6 7.7e-45 152.6 0.0 2.1 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 EXF76505.1 - 1.2e-10 41.2 0.1 7.6e-10 38.6 0.0 2.3 2 0 0 2 2 2 1 Proteasomal ATPase OB C-terminal domain AAA_5 PF07728.14 EXF76505.1 - 2.3e-08 34.1 0.8 6.6e-08 32.6 0.1 2.2 2 2 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 EXF76505.1 - 5.3e-08 33.2 0.0 1.1e-07 32.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 EXF76505.1 - 2.8e-07 31.1 0.6 3.7e-05 24.2 0.0 2.8 2 1 1 3 3 3 1 AAA ATPase domain DUF815 PF05673.13 EXF76505.1 - 3.2e-06 26.5 0.0 6.9e-06 25.4 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_22 PF13401.6 EXF76505.1 - 3.4e-05 24.1 0.9 0.0088 16.3 0.1 2.7 1 1 1 2 2 2 1 AAA domain RuvB_N PF05496.12 EXF76505.1 - 0.00024 20.9 0.0 0.00073 19.3 0.0 1.8 2 0 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 EXF76505.1 - 0.00047 20.7 0.0 0.0013 19.3 0.0 1.7 2 0 0 2 2 1 1 AAA domain AAA_28 PF13521.6 EXF76505.1 - 0.00067 19.9 0.0 0.0014 18.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 EXF76505.1 - 0.00086 18.9 0.1 0.0032 17.0 0.1 1.8 1 1 0 1 1 1 1 P-loop containing dynein motor region AAA_lid_3 PF17862.1 EXF76505.1 - 0.00089 19.0 0.0 0.002 17.9 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain TIP49 PF06068.13 EXF76505.1 - 0.0011 18.3 0.0 0.002 17.4 0.0 1.5 1 0 0 1 1 1 1 TIP49 P-loop domain TsaE PF02367.17 EXF76505.1 - 0.0014 18.7 0.0 0.019 15.0 0.0 2.2 1 1 1 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_14 PF13173.6 EXF76505.1 - 0.002 18.2 0.1 0.0078 16.3 0.0 1.9 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 EXF76505.1 - 0.0021 18.4 0.0 0.0046 17.3 0.0 1.6 1 0 0 1 1 1 1 RNA helicase NTPase_1 PF03266.15 EXF76505.1 - 0.0032 17.4 0.0 0.015 15.2 0.0 2.0 2 0 0 2 2 2 1 NTPase NACHT PF05729.12 EXF76505.1 - 0.004 17.1 0.5 0.12 12.3 0.0 3.0 3 1 0 4 4 3 1 NACHT domain AAA_30 PF13604.6 EXF76505.1 - 0.0051 16.6 1.3 0.013 15.2 0.1 2.3 2 1 0 2 2 2 1 AAA domain AAA_3 PF07726.11 EXF76505.1 - 0.0056 16.5 0.0 0.018 14.9 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 EXF76505.1 - 0.0071 15.7 0.2 0.016 14.6 0.1 1.7 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 EXF76505.1 - 0.0081 16.3 0.0 0.019 15.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 EXF76505.1 - 0.0091 15.7 0.1 0.03 14.0 0.0 1.9 2 0 0 2 2 2 1 IstB-like ATP binding protein Viral_Hsp90 PF03225.14 EXF76505.1 - 0.013 14.1 0.0 0.019 13.5 0.0 1.2 1 0 0 1 1 1 0 Viral heat shock protein Hsp90 homologue TniB PF05621.11 EXF76505.1 - 0.013 14.9 0.0 0.5 9.7 0.0 2.3 2 0 0 2 2 2 0 Bacterial TniB protein AAA_24 PF13479.6 EXF76505.1 - 0.022 14.5 0.2 0.055 13.2 0.2 1.8 1 1 0 1 1 1 0 AAA domain AAA_11 PF13086.6 EXF76505.1 - 0.036 13.8 0.1 0.14 12.0 0.0 2.0 2 0 0 2 2 2 0 AAA domain Bac_DnaA PF00308.18 EXF76505.1 - 0.039 13.8 0.0 0.077 12.8 0.0 1.5 1 0 0 1 1 1 0 Bacterial dnaA protein AFG1_ATPase PF03969.16 EXF76505.1 - 0.04 12.8 0.1 0.13 11.1 0.0 1.8 2 0 0 2 2 2 0 AFG1-like ATPase ATPase PF06745.13 EXF76505.1 - 0.041 13.2 1.3 0.56 9.5 0.0 2.5 3 0 0 3 3 3 0 KaiC ATPase_2 PF01637.18 EXF76505.1 - 0.042 13.8 1.0 0.34 10.8 0.0 2.6 2 1 1 3 3 3 0 ATPase domain predominantly from Archaea AAA_25 PF13481.6 EXF76505.1 - 0.061 12.9 1.0 0.19 11.2 0.3 2.1 2 1 0 2 2 2 0 AAA domain Sigma54_activat PF00158.26 EXF76505.1 - 0.068 12.9 0.2 1.3 8.7 0.0 2.5 2 1 0 2 2 2 0 Sigma-54 interaction domain Zeta_toxin PF06414.12 EXF76505.1 - 0.088 12.1 0.1 0.22 10.8 0.0 1.7 2 0 0 2 2 1 0 Zeta toxin AAA_19 PF13245.6 EXF76505.1 - 0.13 12.6 0.1 0.37 11.1 0.1 1.7 1 0 0 1 1 1 0 AAA domain cobW PF02492.19 EXF76505.1 - 0.14 11.7 0.0 0.34 10.5 0.0 1.6 1 1 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain SPACA9 PF15120.6 EXF76505.1 - 0.15 11.8 1.0 14 5.4 0.0 2.2 2 0 0 2 2 2 0 Sperm acrosome-associated protein 9 AAA_29 PF13555.6 EXF76505.1 - 0.16 11.7 0.0 0.33 10.7 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Parvo_NS1 PF01057.17 EXF76505.1 - 0.2 10.7 0.0 0.37 9.8 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 DUF3530 PF12048.8 EXF76506.1 - 0.015 14.7 0.1 0.015 14.7 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3530) SSFA2_C PF14723.6 EXF76506.1 - 0.068 13.1 2.2 0.081 12.8 2.2 1.2 1 0 0 1 1 1 0 Sperm-specific antigen 2 C-terminus Mis14 PF08641.12 EXF76507.1 - 2e-23 83.2 0.7 2.9e-23 82.7 0.2 1.5 2 0 0 2 2 2 1 Kinetochore protein Mis14 like SOGA PF11365.8 EXF76507.1 - 0.01 16.9 0.5 0.022 15.9 0.5 1.5 1 0 0 1 1 1 0 Protein SOGA Nmad5 PF18757.1 EXF76507.1 - 0.02 15.1 1.1 0.022 14.9 0.1 1.6 2 0 0 2 2 2 0 Nucleotide modification associated domain 5 DUF3138 PF11336.8 EXF76507.1 - 0.02 13.5 1.2 0.027 13.1 1.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) bZIP_1 PF00170.21 EXF76507.1 - 0.052 13.7 0.3 0.91 9.7 0.2 2.4 2 0 0 2 2 2 0 bZIP transcription factor Jnk-SapK_ap_N PF09744.9 EXF76507.1 - 0.055 13.7 5.4 0.46 10.7 0.3 2.7 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 Gp-FAR-1 PF05823.12 EXF76507.1 - 0.18 12.1 2.5 1.1 9.5 2.0 2.3 2 1 0 2 2 2 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) CRAL_TRIO PF00650.20 EXF76508.1 - 1.9e-35 121.9 0.0 3e-35 121.3 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EXF76508.1 - 6.5e-08 32.6 0.4 1.7e-07 31.3 0.0 2.0 2 0 0 2 2 2 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 EXF76508.1 - 0.0057 16.8 0.0 0.015 15.5 0.0 1.6 2 0 0 2 2 2 1 Divergent CRAL/TRIO domain DUF1769 PF08588.10 EXF76508.1 - 0.11 12.7 0.0 0.24 11.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1769) Prefoldin PF02996.17 EXF76509.1 - 4.4e-34 117.0 0.0 7.6e-34 116.2 0.0 1.4 1 0 0 1 1 1 1 Prefoldin subunit Prefoldin_2 PF01920.20 EXF76509.1 - 0.00064 19.6 4.6 0.0032 17.4 0.0 3.0 3 1 1 4 4 4 1 Prefoldin subunit FlaC_arch PF05377.11 EXF76509.1 - 0.0062 16.9 0.9 0.15 12.5 0.1 2.6 2 1 0 2 2 2 1 Flagella accessory protein C (FlaC) Filament PF00038.21 EXF76509.1 - 0.035 13.7 3.1 0.96 9.0 0.1 2.1 2 0 0 2 2 2 0 Intermediate filament protein End3 PF12761.7 EXF76509.1 - 0.036 14.2 0.9 0.24 11.5 0.0 2.3 2 1 0 2 2 2 0 Actin cytoskeleton-regulatory complex protein END3 PIP49_N PF14875.6 EXF76509.1 - 0.14 12.0 0.1 0.25 11.2 0.1 1.3 1 0 0 1 1 1 0 N-term cysteine-rich ER, FAM69 Lebercilin PF15619.6 EXF76509.1 - 0.34 10.6 5.3 0.84 9.3 2.5 2.0 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease Mito_carr PF00153.27 EXF76510.1 - 3e-58 193.7 1.9 1.3e-20 73.1 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein RINT1_TIP1 PF04437.13 EXF76511.1 - 7.9e-183 608.9 0.0 1.9e-182 607.7 0.0 1.6 2 0 0 2 2 2 1 RINT-1 / TIP-1 family Zwint PF15556.6 EXF76511.1 - 0.015 14.8 7.4 0.038 13.5 7.4 1.6 1 0 0 1 1 1 0 ZW10 interactor CRISPR_Cse2 PF09485.10 EXF76511.1 - 0.1 13.1 3.4 0.25 11.9 2.1 2.3 2 0 0 2 2 2 0 CRISPR-associated protein Cse2 (CRISPR_cse2) Atg14 PF10186.9 EXF76511.1 - 0.11 11.5 4.7 0.19 10.8 4.7 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 AD PF09793.9 EXF76511.1 - 0.27 11.4 1.1 20 5.4 0.9 2.7 2 0 0 2 2 2 0 Anticodon-binding domain DHR10 PF18595.1 EXF76511.1 - 0.45 10.6 8.2 0.11 12.6 3.5 2.4 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain DUF4164 PF13747.6 EXF76511.1 - 0.87 9.9 11.1 0.35 11.2 4.6 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF4164) 5-FTHF_cyc-lig PF01812.20 EXF76511.1 - 0.96 9.3 3.2 1.8 8.4 3.2 1.4 1 0 0 1 1 1 0 5-formyltetrahydrofolate cyclo-ligase family DUF883 PF05957.13 EXF76511.1 - 1.1 9.9 8.2 22 5.8 0.1 3.6 3 1 1 4 4 4 0 Bacterial protein of unknown function (DUF883) DUF1664 PF07889.12 EXF76511.1 - 1.4 8.9 4.2 6.9 6.7 2.6 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) COG2 PF06148.11 EXF76511.1 - 3.2 7.9 7.8 9.6 6.3 0.4 3.5 3 1 1 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF4763 PF15960.5 EXF76511.1 - 3.9 6.7 9.9 7.9 5.7 9.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4763) Fig1 PF12351.8 EXF76512.1 - 2.5e-57 193.9 2.6 2.5e-57 193.9 2.6 2.0 2 0 0 2 2 2 1 Ca2+ regulator and membrane fusion protein Fig1 SUR7 PF06687.12 EXF76512.1 - 1.2e-05 25.0 12.5 1.5e-05 24.8 12.0 1.4 1 1 0 1 1 1 1 SUR7/PalI family DUF898 PF05987.13 EXF76512.1 - 0.0016 17.5 10.1 0.0029 16.7 9.8 1.6 1 1 0 1 1 1 1 Bacterial protein of unknown function (DUF898) Glyco_hydro_47 PF01532.20 EXF76513.1 - 2.1e-185 617.0 0.0 2.8e-185 616.6 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 SARAF PF06682.12 EXF76513.1 - 1.8 8.1 7.5 0.085 12.5 1.0 1.9 2 0 0 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis p450 PF00067.22 EXF76515.1 - 1.5e-34 119.6 0.0 6.2e-34 117.5 0.0 1.7 2 0 0 2 2 2 1 Cytochrome P450 RTA1 PF04479.13 EXF76516.1 - 2.4e-66 223.3 11.8 2.4e-66 223.3 11.8 1.3 2 0 0 2 2 2 1 RTA1 like protein TRAP_alpha PF03896.16 EXF76516.1 - 0.11 11.7 0.0 0.2 10.8 0.0 1.4 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Tetraspanin PF00335.20 EXF76516.1 - 2 8.1 14.6 0.045 13.5 3.5 2.4 2 1 0 2 2 2 0 Tetraspanin family Zn_clus PF00172.18 EXF76517.1 - 1.6e-07 31.3 7.6 2.7e-07 30.6 7.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EXF76517.1 - 1.2e-05 24.3 0.0 2e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain YebG PF07130.12 EXF76517.1 - 0.088 12.7 0.2 0.19 11.6 0.2 1.5 1 0 0 1 1 1 0 YebG protein MFS_1 PF07690.16 EXF76518.1 - 2.5e-46 158.2 29.1 2.9e-46 158.0 29.1 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF76518.1 - 2.6e-17 62.9 7.4 3.2e-17 62.5 5.7 1.8 1 1 1 2 2 2 1 Sugar (and other) transporter MFS_4 PF06779.14 EXF76518.1 - 4e-05 23.1 2.3 4e-05 23.1 2.3 1.8 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB TRI12 PF06609.13 EXF76518.1 - 0.00018 20.1 2.4 0.00027 19.5 2.4 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) OATP PF03137.20 EXF76518.1 - 0.0019 16.6 1.5 0.0019 16.6 1.5 2.0 2 1 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family MFS_3 PF05977.13 EXF76518.1 - 0.002 16.6 2.2 0.0028 16.1 2.2 1.2 1 0 0 1 1 1 1 Transmembrane secretion effector FPN1 PF06963.12 EXF76518.1 - 0.0043 15.7 0.0 0.0092 14.6 0.0 1.5 1 0 0 1 1 1 1 Ferroportin1 (FPN1) NPP1 PF05630.11 EXF76519.1 - 6.1e-49 166.8 0.0 7.3e-49 166.6 0.0 1.1 1 0 0 1 1 1 1 Necrosis inducing protein (NPP1) Peptidase_S8 PF00082.22 EXF76521.1 - 7.8e-10 38.5 0.0 1.6e-09 37.5 0.0 1.5 1 0 0 1 1 1 1 Subtilase family PRKG1_interact PF15898.5 EXF76521.1 - 2.2 9.2 8.5 3 8.8 1.2 2.7 2 0 0 2 2 2 0 cGMP-dependent protein kinase interacting domain Ank_2 PF12796.7 EXF76523.1 - 2.7e-59 197.7 1.3 3.1e-13 50.1 0.0 8.4 5 2 2 8 8 8 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EXF76523.1 - 1.3e-53 178.7 5.4 2.6e-07 31.1 0.0 13.1 10 3 4 14 14 14 10 Ankyrin repeats (many copies) Ank_3 PF13606.6 EXF76523.1 - 1.4e-36 120.3 5.4 0.00049 20.3 0.0 15.6 16 0 0 16 16 16 7 Ankyrin repeat Ank PF00023.30 EXF76523.1 - 1.1e-32 111.1 10.4 0.00017 21.9 0.1 12.6 13 0 0 13 13 13 7 Ankyrin repeat Ank_5 PF13857.6 EXF76523.1 - 8.3e-32 108.8 11.5 6.3e-06 26.4 0.1 11.8 10 3 3 13 13 13 7 Ankyrin repeats (many copies) DUF1744 PF08490.12 EXF76524.1 - 1.6e-156 521.0 0.0 2.4e-156 520.3 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1744) DNA_pol_B_exo1 PF03104.19 EXF76524.1 - 2.1e-79 267.1 0.4 4.8e-79 265.9 0.2 1.7 2 0 0 2 2 2 1 DNA polymerase family B, exonuclease domain DNA_pol_B PF00136.21 EXF76524.1 - 2e-14 53.2 1.7 8.3e-13 47.8 1.2 3.1 2 1 0 2 2 2 1 DNA polymerase family B DNA_pol_B_exo2 PF10108.9 EXF76524.1 - 1.2e-08 34.9 0.2 3.4e-08 33.4 0.2 1.7 1 0 0 1 1 1 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB RNase_H_2 PF13482.6 EXF76524.1 - 1.3e-05 25.3 0.1 8.2e-05 22.7 0.0 2.4 2 0 0 2 2 2 1 RNase_H superfamily DUF3767 PF12597.8 EXF76525.1 - 1.2e-37 127.8 0.8 2.2e-37 126.9 0.0 1.7 1 1 1 2 2 2 1 Protein of unknown function (DUF3767) 5TM-5TMR_LYT PF07694.12 EXF76525.1 - 0.0012 18.4 0.2 0.0015 18.1 0.2 1.1 1 0 0 1 1 1 1 5TMR of 5TMR-LYT LapA_dom PF06305.11 EXF76525.1 - 1.9 8.4 3.2 17 5.3 3.2 2.1 1 1 0 1 1 1 0 Lipopolysaccharide assembly protein A domain Aldose_epim PF01263.20 EXF76527.1 - 5.6e-55 186.8 0.0 7e-55 186.4 0.0 1.1 1 0 0 1 1 1 1 Aldose 1-epimerase zf-met2 PF12907.7 EXF76527.1 - 0.016 15.3 0.4 0.039 14.1 0.4 1.6 1 0 0 1 1 1 0 Zinc-binding Glyco_transf_20 PF00982.21 EXF76529.1 - 8.7e-199 661.1 0.0 1e-198 660.9 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 20 Glyco_transf_5 PF08323.11 EXF76529.1 - 0.03 14.0 0.1 0.1 12.3 0.0 1.9 2 0 0 2 2 2 0 Starch synthase catalytic domain Med28 PF11594.8 EXF76529.1 - 0.069 13.2 0.1 0.46 10.6 0.2 2.1 2 0 0 2 2 2 0 Mediator complex subunit 28 VID27 PF08553.10 EXF76530.1 - 4.9e-194 644.2 0.1 6.5e-194 643.8 0.1 1.1 1 0 0 1 1 1 1 VID27 C-terminal WD40-like domain VID27_N PF17748.1 EXF76530.1 - 2.6e-77 258.5 0.2 2.6e-77 258.5 0.2 2.8 2 1 0 2 2 2 1 VID27 N-terminal region VID27_PH PF17747.1 EXF76530.1 - 8.1e-44 148.4 1.1 1.7e-43 147.4 0.6 1.8 2 0 0 2 2 2 1 VID27 PH-like domain DNA_pol_phi PF04931.13 EXF76530.1 - 0.16 10.0 13.2 0.25 9.4 13.2 1.2 1 0 0 1 1 1 0 DNA polymerase phi Herpes_gE PF02480.16 EXF76530.1 - 0.52 9.0 4.7 0.84 8.3 4.7 1.3 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E CDC45 PF02724.14 EXF76530.1 - 1.1 7.5 7.5 1.5 7.0 7.5 1.1 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 EXF76530.1 - 1.8 6.6 13.8 2.9 6.0 13.8 1.2 1 0 0 1 1 1 0 Nop14-like family Pox_Ag35 PF03286.14 EXF76530.1 - 5.5 6.7 18.9 0.53 10.1 0.6 2.3 2 0 0 2 2 2 0 Pox virus Ag35 surface protein Astro_capsid_p PF12226.8 EXF76530.1 - 6 5.9 18.7 10 5.1 18.7 1.3 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Prenylcys_lyase PF07156.14 EXF76531.1 - 5.8e-112 374.4 0.0 7.5e-112 374.0 0.0 1.1 1 0 0 1 1 1 1 Prenylcysteine lyase Amino_oxidase PF01593.24 EXF76531.1 - 2.5e-12 46.9 0.0 3.4e-12 46.4 0.0 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EXF76531.1 - 5.7e-12 45.7 0.0 1.7e-11 44.2 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EXF76531.1 - 1.1e-06 28.5 0.1 3e-05 23.8 0.2 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EXF76531.1 - 0.00025 20.4 0.2 0.018 14.3 0.1 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EXF76531.1 - 0.0042 17.1 0.1 0.04 13.9 0.0 2.3 2 0 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox PF00070.27 EXF76531.1 - 0.11 13.1 0.1 2.9 8.5 0.1 2.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase MCRA PF06100.11 EXF76531.1 - 0.13 11.1 0.0 0.53 9.0 0.0 1.9 2 0 0 2 2 2 0 MCRA family Thi4 PF01946.17 EXF76531.1 - 0.13 11.5 0.1 0.29 10.3 0.1 1.5 1 0 0 1 1 1 0 Thi4 family Cpn60_TCP1 PF00118.24 EXF76532.1 - 3e-163 544.0 1.3 3.4e-163 543.8 1.3 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Herpes_UL6 PF01763.16 EXF76532.1 - 0.12 10.9 0.0 0.17 10.4 0.0 1.1 1 0 0 1 1 1 0 Herpesvirus UL6 like PDCD2_C PF04194.13 EXF76533.1 - 4.9e-43 147.2 1.0 1.9e-42 145.3 0.0 2.3 3 0 0 3 3 3 1 Programmed cell death protein 2, C-terminal putative domain Ribosomal_60s PF00428.19 EXF76533.1 - 0.031 14.9 13.6 0.07 13.7 2.3 2.5 2 0 0 2 2 2 0 60s Acidic ribosomal protein DUF3484 PF11983.8 EXF76533.1 - 8.6 7.6 7.4 33 5.7 0.6 2.8 3 0 0 3 3 3 0 Membrane-attachment and polymerisation-promoting switch CSN8_PSD8_EIF3K PF10075.9 EXF76534.1 - 3.2e-39 134.2 0.0 4.4e-39 133.7 0.0 1.2 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family DNA_ligase_A_M PF01068.21 EXF76535.1 - 7.8e-49 166.1 0.2 3.3e-46 157.5 0.0 2.2 2 0 0 2 2 2 2 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 EXF76535.1 - 4.2e-35 121.6 0.0 8e-35 120.7 0.0 1.5 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.15 EXF76535.1 - 1.4e-20 73.7 0.1 7.2e-20 71.4 0.0 2.3 3 0 0 3 3 3 1 ATP dependent DNA ligase C terminal region RNA_ligase PF09414.10 EXF76535.1 - 0.00083 19.7 0.0 0.0036 17.6 0.0 2.0 2 0 0 2 2 2 1 RNA ligase mRNA_cap_enzyme PF01331.19 EXF76535.1 - 0.064 13.1 0.1 2.1 8.1 0.0 2.2 2 0 0 2 2 2 0 mRNA capping enzyme, catalytic domain NuDC PF16273.5 EXF76535.1 - 3.4 8.3 12.1 0.049 14.2 4.1 2.1 2 0 0 2 2 2 0 Nuclear distribution C domain Adaptin_N PF01602.20 EXF76536.1 - 2.1e-138 462.1 1.6 3e-138 461.7 1.6 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EXF76536.1 - 6.8e-63 211.5 1.2 8.9e-61 204.6 0.1 2.7 2 1 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EXF76536.1 - 5.7e-17 61.9 0.1 2.3e-07 31.1 0.0 5.2 2 2 5 7 7 7 4 HEAT repeats HEAT PF02985.22 EXF76536.1 - 5.2e-11 41.8 4.4 0.023 14.9 0.0 6.4 8 0 0 8 8 8 3 HEAT repeat HEAT_EZ PF13513.6 EXF76536.1 - 0.00014 22.3 0.1 0.64 10.6 0.0 4.7 3 1 1 4 4 4 1 HEAT-like repeat UNC45-central PF11701.8 EXF76536.1 - 0.0043 17.0 0.1 0.25 11.3 0.0 2.7 2 0 0 2 2 2 1 Myosin-binding striated muscle assembly central RIX1 PF08167.12 EXF76536.1 - 0.0098 15.6 0.1 3.5 7.3 0.0 2.9 3 0 0 3 3 3 1 rRNA processing/ribosome biogenesis Atx10homo_assoc PF09759.9 EXF76536.1 - 0.011 15.8 0.0 1.8 8.7 0.0 3.5 2 1 1 3 3 3 0 Spinocerebellar ataxia type 10 protein domain Arm PF00514.23 EXF76536.1 - 0.015 15.3 1.4 7.6 6.7 0.0 4.9 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat CLASP_N PF12348.8 EXF76536.1 - 0.05 13.1 0.0 1.7 8.2 0.0 2.9 2 1 1 3 3 3 0 CLASP N terminal BolA PF01722.18 EXF76537.1 - 2.3e-20 72.7 0.1 5.9e-20 71.3 0.1 1.6 1 1 0 1 1 1 1 BolA-like protein Nrap_D3 PF17404.2 EXF76537.1 - 0.12 12.5 0.3 2.7 8.1 0.0 2.0 1 1 1 2 2 2 0 Nrap protein domain 3 zf-C2H2_11 PF16622.5 EXF76537.1 - 0.19 11.5 0.4 8.1 6.3 0.0 2.3 2 0 0 2 2 2 0 zinc-finger C2H2-type NIF3 PF01784.18 EXF76538.1 - 5e-60 203.2 0.0 6e-60 202.9 0.0 1.0 1 0 0 1 1 1 1 NIF3 (NGG1p interacting factor 3) Phosphonate-bd PF12974.7 EXF76538.1 - 0.0068 16.0 0.1 0.0096 15.5 0.1 1.3 1 0 0 1 1 1 1 ABC transporter, phosphonate, periplasmic substrate-binding protein AdoMet_dc PF02675.15 EXF76538.1 - 0.092 13.0 0.0 0.2 11.9 0.0 1.5 1 0 0 1 1 1 0 S-adenosylmethionine decarboxylase Vps51 PF08700.11 EXF76539.1 - 3.9e-30 103.8 0.1 8.4e-30 102.7 0.0 1.6 2 0 0 2 2 2 1 Vps51/Vps67 Dor1 PF04124.12 EXF76539.1 - 0.00067 18.4 0.1 0.00093 18.0 0.1 1.1 1 0 0 1 1 1 1 Dor1-like family COG5 PF10392.9 EXF76539.1 - 0.0012 19.0 0.0 0.002 18.3 0.0 1.4 1 1 0 1 1 1 1 Golgi transport complex subunit 5 AbiEi_4 PF13338.6 EXF76539.1 - 0.35 11.0 3.2 0.95 9.7 1.6 2.3 2 0 0 2 2 2 0 Transcriptional regulator, AbiEi antitoxin RMI1_N PF08585.12 EXF76540.1 - 2.2e-54 184.5 0.0 2.5e-54 184.3 0.0 1.0 1 0 0 1 1 1 1 RecQ mediated genome instability protein K_channel_TID PF07941.11 EXF76540.1 - 0.73 10.3 5.6 1.2 9.7 5.6 1.3 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain TPR_16 PF13432.6 EXF76541.1 - 1.3e-32 112.2 26.3 1.2e-06 29.0 0.2 11.7 10 2 1 11 11 10 7 Tetratricopeptide repeat TPR_2 PF07719.17 EXF76541.1 - 1.3e-31 106.1 34.0 0.00022 21.1 0.0 15.7 17 0 0 17 17 16 8 Tetratricopeptide repeat TPR_19 PF14559.6 EXF76541.1 - 8e-30 103.2 18.6 4.4e-05 23.9 0.9 10.8 9 2 1 10 10 10 5 Tetratricopeptide repeat TPR_14 PF13428.6 EXF76541.1 - 1.1e-28 97.4 25.5 0.0011 19.6 0.0 15.9 10 6 7 17 17 16 5 Tetratricopeptide repeat TPR_1 PF00515.28 EXF76541.1 - 4.2e-28 96.0 29.8 5.1e-06 26.1 0.0 13.9 14 0 0 14 14 13 7 Tetratricopeptide repeat TPR_17 PF13431.6 EXF76541.1 - 5.5e-24 82.8 10.2 0.68 10.4 0.0 14.4 15 0 0 15 15 13 4 Tetratricopeptide repeat TPR_8 PF13181.6 EXF76541.1 - 8.5e-19 66.1 26.5 0.0075 16.4 0.0 14.2 15 0 0 15 15 14 4 Tetratricopeptide repeat TPR_11 PF13414.6 EXF76541.1 - 2.9e-16 58.9 22.5 0.016 14.9 0.0 12.0 12 1 1 13 13 12 3 TPR repeat TPR_12 PF13424.6 EXF76541.1 - 1.6e-15 57.1 34.6 0.02 15.1 0.0 13.2 10 4 3 13 13 13 4 Tetratricopeptide repeat TPR_6 PF13174.6 EXF76541.1 - 4.7e-11 42.6 20.3 0.55 11.0 0.0 14.4 18 0 0 18 18 14 2 Tetratricopeptide repeat TPR_9 PF13371.6 EXF76541.1 - 4.6e-09 36.3 7.3 0.25 11.5 0.1 6.7 6 1 0 6 6 5 3 Tetratricopeptide repeat TPR_7 PF13176.6 EXF76541.1 - 3e-08 33.1 25.0 0.0032 17.4 0.0 11.5 13 1 1 14 14 11 2 Tetratricopeptide repeat TPR_22 PF18833.1 EXF76541.1 - 1e-07 32.0 0.0 3.8e-07 30.2 0.0 2.1 1 0 0 1 1 1 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EXF76541.1 - 2.6e-06 27.6 18.6 1.6 9.0 0.0 9.0 9 1 1 10 10 9 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_20 PF14561.6 EXF76541.1 - 0.0018 18.6 10.5 3.2 8.2 0.1 6.1 5 0 0 5 5 5 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EXF76541.1 - 0.0023 18.0 0.1 1.5 8.9 0.0 4.8 6 0 0 6 6 5 1 Fis1 C-terminal tetratricopeptide repeat RPN6_N PF18055.1 EXF76541.1 - 0.017 15.5 1.7 0.13 12.6 0.2 3.5 3 0 0 3 3 1 0 26S proteasome regulatory subunit RPN6 N-terminal domain ChAPs PF09295.10 EXF76541.1 - 0.019 14.0 1.8 9.8 5.0 0.4 3.8 5 0 0 5 5 5 0 ChAPs (Chs5p-Arf1p-binding proteins) HrpB1_HrpK PF09613.10 EXF76541.1 - 0.02 14.5 0.3 23 4.6 0.0 4.2 4 0 0 4 4 4 0 Bacterial type III secretion protein (HrpB1_HrpK) DUF5588 PF17826.1 EXF76541.1 - 0.022 13.6 0.5 0.34 9.8 0.0 2.9 3 0 0 3 3 3 0 Family of unknown function (DUF5588) Coatomer_WDAD PF04053.14 EXF76541.1 - 0.023 13.7 0.0 0.052 12.6 0.0 1.5 1 0 0 1 1 1 0 Coatomer WD associated region NRBF2_MIT PF17169.4 EXF76541.1 - 0.051 13.8 1.8 0.43 10.8 0.4 3.4 2 0 0 2 2 2 0 MIT domain of nuclear receptor-binding factor 2 DUF4919 PF16266.5 EXF76541.1 - 0.061 13.3 0.4 1.8 8.4 0.1 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4919) PPTA PF01239.22 EXF76541.1 - 0.093 12.5 1.1 15 5.5 0.0 3.6 4 0 0 4 4 3 0 Protein prenyltransferase alpha subunit repeat HemY_N PF07219.13 EXF76541.1 - 0.18 12.0 10.8 18 5.6 0.1 5.8 5 1 1 6 6 5 0 HemY protein N-terminus DUF4192 PF13830.6 EXF76541.1 - 0.34 10.9 12.5 0.3 11.1 0.2 3.2 4 0 0 4 4 2 0 Domain of unknown function (DUF4192) Pkinase PF00069.25 EXF76542.1 - 1.5e-63 214.6 0.0 2.2e-63 214.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF76542.1 - 2.3e-47 161.5 0.0 3.6e-47 160.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EXF76542.1 - 4.1e-08 32.9 0.0 1.9e-06 27.4 0.0 2.1 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 EXF76542.1 - 0.0042 16.5 0.0 0.009 15.4 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EXF76542.1 - 0.0093 14.8 0.6 0.02 13.7 0.0 1.8 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 EXF76542.1 - 0.044 13.7 0.0 0.088 12.7 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family FTA2 PF13095.6 EXF76542.1 - 0.083 12.5 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 p450 PF00067.22 EXF76543.1 - 1.4e-61 208.6 0.0 2.1e-61 208.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Epimerase PF01370.21 EXF76544.1 - 3.8e-12 46.2 0.0 6.8e-12 45.4 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EXF76544.1 - 1.7e-08 34.6 0.1 2.9e-08 33.8 0.1 1.3 1 0 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 EXF76544.1 - 1.2e-06 27.8 0.3 7.7e-06 25.1 0.1 2.1 2 1 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family NmrA PF05368.13 EXF76544.1 - 1.9e-06 27.6 0.4 3e-06 27.0 0.4 1.3 1 0 0 1 1 1 1 NmrA-like family RmlD_sub_bind PF04321.17 EXF76544.1 - 4.8e-05 22.6 0.0 0.00062 18.9 0.0 2.1 1 1 0 1 1 1 1 RmlD substrate binding domain GDP_Man_Dehyd PF16363.5 EXF76544.1 - 0.00076 19.0 0.5 0.0032 16.9 0.1 2.1 3 0 0 3 3 3 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 EXF76544.1 - 0.0011 18.2 0.2 0.0032 16.7 0.1 1.8 2 0 0 2 2 2 1 Male sterility protein KR PF08659.10 EXF76544.1 - 0.013 15.4 0.1 0.035 14.0 0.1 1.8 1 1 0 1 1 1 0 KR domain adh_short PF00106.25 EXF76544.1 - 0.017 14.6 0.2 0.029 13.8 0.2 1.4 1 0 0 1 1 1 0 short chain dehydrogenase TrkA_N PF02254.18 EXF76544.1 - 0.16 12.3 0.1 0.3 11.3 0.1 1.5 1 0 0 1 1 1 0 TrkA-N domain Glyco_hydro_5_C PF18564.1 EXF76545.1 - 4.9e-23 81.5 0.0 1.2e-22 80.2 0.0 1.7 2 0 0 2 2 2 1 Glycoside hydrolase family 5 C-terminal domain Cellulase PF00150.18 EXF76545.1 - 1e-11 44.8 2.5 3.6e-09 36.5 1.0 2.5 2 1 0 2 2 2 2 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_35 PF01301.19 EXF76545.1 - 0.029 14.0 0.2 0.053 13.1 0.2 1.3 1 0 0 1 1 1 0 Glycosyl hydrolases family 35 Glyco_hydro_42 PF02449.15 EXF76545.1 - 0.035 13.4 0.1 0.32 10.3 0.0 2.2 2 0 0 2 2 2 0 Beta-galactosidase Sugar_tr PF00083.24 EXF76546.1 - 5.1e-65 220.1 5.9 3.5e-33 115.1 0.8 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 EXF76546.1 - 7.9e-14 51.3 32.5 5.2e-09 35.5 8.1 2.4 2 1 0 2 2 2 2 Major Facilitator Superfamily PMT_4TMC PF16192.5 EXF76546.1 - 0.43 10.1 3.5 0.29 10.7 0.4 2.1 2 0 0 2 2 2 0 C-terminal four TMM region of protein-O-mannosyltransferase Ank_2 PF12796.7 EXF76547.1 - 1e-19 70.9 0.0 1e-08 35.6 0.0 4.1 2 2 2 4 4 4 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EXF76547.1 - 4.4e-17 62.2 0.9 1.1e-05 25.8 0.0 5.2 2 2 3 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.30 EXF76547.1 - 3e-14 52.7 3.2 0.0016 18.8 0.0 5.6 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 EXF76547.1 - 1.2e-12 47.8 0.6 0.001 19.3 0.1 4.7 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EXF76547.1 - 1.9e-10 40.1 0.0 0.00012 22.2 0.0 5.6 5 0 0 5 5 5 1 Ankyrin repeat TPR_8 PF13181.6 EXF76547.1 - 0.00021 21.3 0.0 0.00077 19.5 0.0 2.0 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_12 PF13424.6 EXF76547.1 - 0.00085 19.6 1.0 0.0024 18.1 0.1 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 EXF76547.1 - 0.0012 19.5 2.7 0.14 13.0 0.0 4.2 3 1 1 4 4 4 1 Tetratricopeptide repeat Helo_like_N PF17111.5 EXF76547.1 - 0.0042 16.5 0.2 0.011 15.1 0.2 1.7 1 0 0 1 1 1 1 Fungal N-terminal domain of STAND proteins TPR_2 PF07719.17 EXF76547.1 - 0.0079 16.2 0.2 0.028 14.5 0.1 2.1 2 0 0 2 2 1 1 Tetratricopeptide repeat DUF2656 PF10847.8 EXF76547.1 - 0.014 15.5 0.1 0.05 13.7 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2656) TPR_19 PF14559.6 EXF76547.1 - 0.015 15.8 3.7 0.031 14.8 0.5 3.2 3 1 1 4 4 4 0 Tetratricopeptide repeat SesA PF17107.5 EXF76547.1 - 0.016 15.4 0.4 0.049 13.8 0.1 2.0 2 0 0 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases TPR_1 PF00515.28 EXF76547.1 - 0.017 14.9 0.2 0.13 12.1 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 EXF76547.1 - 0.021 14.8 0.0 0.096 12.8 0.0 2.2 1 0 0 1 1 1 0 Tetratricopeptide repeat RPN7 PF10602.9 EXF76547.1 - 0.034 13.9 0.5 0.26 11.0 0.2 2.4 2 0 0 2 2 2 0 26S proteasome subunit RPN7 EST1_DNA_bind PF10373.9 EXF76547.1 - 0.14 11.6 1.3 5.3 6.4 0.1 2.6 1 1 1 2 2 2 0 Est1 DNA/RNA binding domain HET PF06985.11 EXF76548.1 - 1.9e-30 106.1 0.0 3.2e-30 105.4 0.0 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) DUF2637 PF10935.8 EXF76548.1 - 0.12 12.2 0.0 0.27 11.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2637) ATP-synt_C PF00137.21 EXF76549.1 - 1.1e-10 41.7 12.5 1.1e-10 41.7 12.5 1.8 2 0 0 2 2 2 1 ATP synthase subunit C AFP PF02420.15 EXF76550.1 - 0.3 11.5 2.5 67 4.4 0.1 3.7 3 0 0 3 3 3 0 Insect antifreeze protein repeat Ctr PF04145.15 EXF76551.1 - 8.9e-28 97.8 0.4 1.2e-27 97.4 0.4 1.1 1 0 0 1 1 1 1 Ctr copper transporter family SRF-TF PF00319.18 EXF76552.1 - 5.9e-21 73.7 0.1 8.2e-21 73.2 0.1 1.2 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) MRI PF15325.6 EXF76552.1 - 1.2 10.3 3.8 0.94 10.6 0.5 2.1 2 0 0 2 2 2 0 Modulator of retrovirus infection Fasciclin PF02469.22 EXF76554.1 - 1.4e-17 64.1 0.0 1.8e-17 63.8 0.0 1.1 1 0 0 1 1 1 1 Fasciclin domain Melibiase_2 PF16499.5 EXF76555.1 - 5.7e-39 134.0 2.5 2.1e-38 132.1 2.5 1.9 1 1 0 1 1 1 1 Alpha galactosidase A Glyco_hydro_88 PF07470.13 EXF76555.1 - 2.8e-13 49.7 0.6 5.6e-13 48.7 0.6 1.5 1 0 0 1 1 1 1 Glycosyl Hydrolase Family 88 Melibiase_C PF17801.1 EXF76555.1 - 5.3e-07 29.6 0.2 1.2e-06 28.5 0.2 1.6 1 0 0 1 1 1 1 Alpha galactosidase C-terminal beta sandwich domain Raffinose_syn PF05691.12 EXF76555.1 - 0.00019 19.4 0.0 0.00027 18.9 0.0 1.1 1 0 0 1 1 1 1 Raffinose synthase or seed imbibition protein Sip1 Fungal_trans PF04082.18 EXF76556.1 - 6e-11 41.9 4.2 1.7e-09 37.1 0.1 2.7 2 1 1 3 3 3 2 Fungal specific transcription factor domain MFS_1 PF07690.16 EXF76557.1 - 2.7e-21 75.9 28.7 1.9e-12 46.8 5.5 2.3 2 1 1 3 3 3 2 Major Facilitator Superfamily 2TM PF13239.6 EXF76557.1 - 0.038 14.3 0.1 0.038 14.3 0.1 4.4 4 1 1 5 5 5 0 2TM domain LamB_YcsF PF03746.16 EXF76558.1 - 3.8e-82 275.6 0.0 4.3e-82 275.4 0.0 1.0 1 0 0 1 1 1 1 LamB/YcsF family CT_A_B PF02626.15 EXF76559.1 - 1.6e-75 254.2 0.0 2.4e-75 253.6 0.0 1.3 1 0 0 1 1 1 1 Carboxyltransferase domain, subdomain A and B CPSase_L_D2 PF02786.17 EXF76559.1 - 1.6e-53 181.3 0.0 4.1e-53 180.0 0.0 1.6 2 0 0 2 2 2 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 EXF76559.1 - 1.5e-38 131.7 0.0 3.3e-38 130.6 0.0 1.6 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 EXF76559.1 - 1.7e-31 108.5 0.0 3.3e-31 107.6 0.0 1.5 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain CT_C_D PF02682.16 EXF76559.1 - 2.6e-31 109.0 0.0 6.8e-31 107.6 0.0 1.7 1 0 0 1 1 1 1 Carboxyltransferase domain, subdomain C and D Biotin_lipoyl PF00364.22 EXF76559.1 - 1.3e-09 37.7 2.7 3e-08 33.4 2.5 3.1 3 0 0 3 3 3 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.13 EXF76559.1 - 1e-05 25.2 0.0 3e-05 23.6 0.0 1.7 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp_5 PF13549.6 EXF76559.1 - 0.0025 17.3 0.0 0.0053 16.2 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp PF02222.22 EXF76559.1 - 0.0034 17.0 0.0 0.008 15.8 0.0 1.6 2 0 0 2 2 2 1 ATP-grasp domain Zn_clus PF00172.18 EXF76560.1 - 5e-10 39.3 6.8 9e-10 38.5 6.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EXF76560.1 - 2.3e-08 33.4 0.0 1.1e-07 31.2 0.0 2.0 2 1 0 2 2 2 1 Fungal specific transcription factor domain ABC2_membrane PF01061.24 EXF76561.1 - 4.8e-27 94.7 25.8 6.6e-27 94.3 25.8 1.2 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 EXF76561.1 - 3.4e-26 92.4 0.0 6.2e-26 91.5 0.0 1.5 1 0 0 1 1 1 1 ABC transporter RsgA_GTPase PF03193.16 EXF76561.1 - 3.7e-06 26.9 0.1 7.1e-05 22.8 0.1 2.2 2 0 0 2 2 2 1 RsgA GTPase AAA_25 PF13481.6 EXF76561.1 - 2.9e-05 23.7 0.0 5.8e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EXF76561.1 - 0.00075 19.9 0.4 0.0016 18.9 0.0 1.8 2 0 0 2 2 2 1 AAA ATPase domain SMC_N PF02463.19 EXF76561.1 - 0.0025 17.3 0.0 0.007 15.8 0.0 1.6 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EXF76561.1 - 0.0039 17.0 0.0 2.6 7.7 0.0 2.3 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA PF00004.29 EXF76561.1 - 0.0078 16.6 0.0 0.044 14.2 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 EXF76561.1 - 0.011 15.6 0.0 0.019 14.9 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_22 PF13401.6 EXF76561.1 - 0.012 15.9 0.0 0.025 14.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_13 PF13166.6 EXF76561.1 - 0.041 12.5 0.1 0.041 12.5 0.1 2.0 3 0 0 3 3 3 0 AAA domain AAA_28 PF13521.6 EXF76561.1 - 0.048 13.9 0.1 0.099 12.9 0.1 1.5 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EXF76561.1 - 0.08 12.7 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 EXF76561.1 - 0.092 12.8 0.2 0.21 11.7 0.2 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase Peptidase_S77 PF03420.13 EXF76561.1 - 0.14 11.8 0.0 0.27 10.9 0.0 1.4 1 0 0 1 1 1 0 Prohead core protein serine protease cobW PF02492.19 EXF76561.1 - 0.15 11.6 0.0 0.28 10.8 0.0 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain PDR_CDR PF06422.12 EXF76561.1 - 0.17 11.8 0.1 0.17 11.8 0.1 2.3 2 1 1 3 3 1 0 CDR ABC transporter NCA2 PF08637.10 EXF76561.1 - 0.41 9.8 1.1 0.83 8.8 1.1 1.4 1 0 0 1 1 1 0 ATP synthase regulation protein NCA2 ABC2_membrane_3 PF12698.7 EXF76561.1 - 0.44 9.6 28.1 0.19 10.8 24.3 2.0 1 1 1 2 2 2 0 ABC-2 family transporter protein DUF2070 PF09843.9 EXF76561.1 - 5.3 5.2 11.8 8.4 4.5 11.8 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) DNApol_Exo PF18136.1 EXF76562.1 - 6.4e-105 350.3 0.0 1.2e-104 349.4 0.0 1.4 1 0 0 1 1 1 1 DNA mitochondrial polymerase exonuclease domain DNA_pol_A PF00476.20 EXF76562.1 - 1.3e-55 189.0 0.0 2.3e-55 188.2 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase family A zf-C3HC4_3 PF13920.6 EXF76563.1 - 2.9e-11 43.0 7.8 4.4e-11 42.5 7.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EXF76563.1 - 1.9e-08 34.0 10.3 3.3e-08 33.2 10.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EXF76563.1 - 3.4e-08 33.2 8.5 6.1e-08 32.4 8.5 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 EXF76563.1 - 1.4e-07 31.8 9.0 2.2e-07 31.1 9.0 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 EXF76563.1 - 3.1e-07 30.2 9.4 5.7e-07 29.4 9.4 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 EXF76563.1 - 4.4e-07 29.7 9.8 7.2e-07 29.0 9.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EXF76563.1 - 5.6e-07 29.5 5.8 5.6e-07 29.5 2.8 2.3 1 1 1 2 2 2 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 EXF76563.1 - 1.7e-05 24.8 3.4 2.8e-05 24.1 3.4 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.6 EXF76563.1 - 0.0005 19.8 5.4 0.00095 18.9 5.4 1.5 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-rbx1 PF12678.7 EXF76563.1 - 0.0021 18.3 5.2 0.0046 17.2 5.2 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_4 PF15227.6 EXF76563.1 - 0.011 15.8 7.9 0.021 15.0 7.9 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING TerY_C PF15616.6 EXF76563.1 - 0.07 13.2 1.7 0.12 12.5 1.7 1.4 1 0 0 1 1 1 0 TerY-C metal binding domain zf-RING_11 PF17123.5 EXF76563.1 - 0.083 12.6 10.1 0.17 11.6 7.0 2.3 2 0 0 2 2 2 0 RING-like zinc finger zf-RING_6 PF14835.6 EXF76563.1 - 0.23 11.4 2.6 0.38 10.7 2.6 1.3 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-P11 PF03854.14 EXF76563.1 - 0.78 9.5 4.8 1.5 8.6 4.8 1.4 1 0 0 1 1 1 0 P-11 zinc finger DZR PF12773.7 EXF76563.1 - 1.1 9.3 5.7 3.2 7.8 5.7 1.8 1 1 0 1 1 1 0 Double zinc ribbon RNHCP PF12647.7 EXF76563.1 - 3.6 7.6 8.4 13 5.8 8.4 1.9 1 1 0 1 1 1 0 RNHCP domain FYVE PF01363.21 EXF76563.1 - 8.2 6.6 8.4 38 4.5 8.2 2.0 1 1 1 2 2 2 0 FYVE zinc finger Nup192 PF11894.8 EXF76564.1 - 0 1543.5 0.0 0 1543.2 0.0 1.0 1 0 0 1 1 1 1 Nuclear pore complex scaffold, nucleoporins 186/192/205 TAN PF11640.8 EXF76566.1 - 2.6e-38 131.5 0.0 4.1e-37 127.6 0.0 2.4 3 0 0 3 3 3 1 Telomere-length maintenance and DNA damage repair Cnd1 PF12717.7 EXF76566.1 - 0.031 14.3 0.7 0.13 12.3 0.0 2.3 3 0 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 RskA PF10099.9 EXF76567.1 - 0.14 12.4 5.9 0.16 12.2 5.9 1.1 1 0 0 1 1 1 0 Anti-sigma-K factor rskA GDPD PF03009.17 EXF76569.1 - 2.1e-69 234.2 0.0 6.6e-69 232.5 0.0 1.9 2 0 0 2 2 2 1 Glycerophosphoryl diester phosphodiesterase family Ank_2 PF12796.7 EXF76569.1 - 1.9e-26 92.5 0.0 3.1e-08 34.1 0.1 3.9 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EXF76569.1 - 4.9e-25 87.6 1.8 2.7e-08 34.2 0.1 5.7 4 1 0 5 5 5 3 Ankyrin repeats (many copies) SPX PF03105.19 EXF76569.1 - 1.1e-21 78.3 8.9 1e-10 42.1 0.1 3.8 2 1 1 4 4 4 3 SPX domain Ank_5 PF13857.6 EXF76569.1 - 1.5e-17 63.4 0.6 2.6e-06 27.6 0.0 5.5 2 2 3 5 5 5 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EXF76569.1 - 6.9e-16 56.8 0.4 0.015 15.7 0.0 7.2 7 0 0 7 7 7 3 Ankyrin repeat Ank PF00023.30 EXF76569.1 - 6.7e-15 54.8 2.0 0.003 17.9 0.0 6.3 6 0 0 6 6 6 3 Ankyrin repeat DUF866 PF05907.13 EXF76572.1 - 3e-66 222.1 0.8 3.3e-66 222.0 0.8 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF866) Zn_ribbon_SprT PF17283.2 EXF76572.1 - 0.11 12.5 2.5 4.6 7.2 0.1 2.2 2 0 0 2 2 2 0 SprT-like zinc ribbon domain HalOD2 PF18547.1 EXF76572.1 - 0.14 12.1 1.2 1.4 8.9 0.1 2.2 2 0 0 2 2 2 0 Halobacterial output domain 2 DUF4379 PF14311.6 EXF76572.1 - 0.66 10.4 6.0 0.19 12.1 1.5 2.3 1 1 1 2 2 2 0 Probable Zinc-ribbon domain Metallophos PF00149.28 EXF76573.1 - 1.4e-31 110.6 0.0 2.4e-27 96.8 0.0 2.5 2 0 0 2 2 2 2 Calcineurin-like phosphoesterase Glyco_hydro_65N PF03636.15 EXF76573.1 - 0.053 13.2 0.0 0.093 12.4 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain Smg4_UPF3 PF03467.15 EXF76574.1 - 1.3e-48 165.3 0.0 1.3e-48 165.3 0.0 3.7 4 0 0 4 4 4 1 Smg-4/UPF3 family RRM_1 PF00076.22 EXF76574.1 - 3.2e-06 26.9 0.0 0.00021 21.0 0.0 2.6 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) XRN_M PF17846.1 EXF76574.1 - 9 5.1 12.8 2.1 7.2 0.1 2.4 2 0 0 2 2 2 0 Xrn1 helical domain IBN_N PF03810.19 EXF76575.1 - 7.2e-11 41.9 0.2 1.2e-09 38.0 0.1 2.8 2 0 0 2 2 2 1 Importin-beta N-terminal domain Xpo1 PF08389.12 EXF76575.1 - 0.0035 17.4 0.0 8.2 6.5 0.0 3.9 4 0 0 4 4 4 2 Exportin 1-like protein HEAT PF02985.22 EXF76575.1 - 0.024 14.9 0.1 9.9 6.7 0.0 4.1 3 0 0 3 3 3 0 HEAT repeat CAS_CSE1 PF03378.15 EXF76575.1 - 0.025 13.1 0.0 0.043 12.3 0.0 1.4 1 0 0 1 1 1 0 CAS/CSE protein, C-terminus Ribosomal_60s PF00428.19 EXF76575.1 - 0.075 13.6 3.3 0.23 12.1 3.3 1.9 1 0 0 1 1 1 0 60s Acidic ribosomal protein RhoGEF PF00621.20 EXF76576.1 - 1.4e-27 97.2 1.3 5.8e-27 95.1 0.1 2.2 2 0 0 2 2 2 1 RhoGEF domain DUF3507 PF12015.8 EXF76576.1 - 0.039 13.7 0.0 0.079 12.7 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3507) MRP-S31 PF15433.6 EXF76576.1 - 0.28 10.8 6.4 0.6 9.7 6.4 1.5 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S31 CdvA PF18822.1 EXF76576.1 - 0.61 9.9 14.6 2.5 8.0 1.8 3.4 1 1 2 3 3 3 0 CdvA-like coiled-coil domain T4SS PF07996.11 EXF76576.1 - 1.3 9.4 4.2 13 6.2 0.1 2.9 3 0 0 3 3 3 0 Type IV secretion system proteins Rab5-bind PF09311.11 EXF76576.1 - 2.7 7.3 13.1 0.36 10.2 6.6 2.3 1 1 1 2 2 2 0 Rabaptin-like protein ECH_2 PF16113.5 EXF76576.1 - 7.6 5.9 8.8 0.98 8.8 1.2 2.7 3 0 0 3 3 3 0 Enoyl-CoA hydratase/isomerase Dcc1 PF09724.9 EXF76577.1 - 3.1e-11 43.2 0.1 3.5e-11 43.0 0.1 1.0 1 0 0 1 1 1 1 Sister chromatid cohesion protein Dcc1 Mcm10 PF09332.11 EXF76577.1 - 0.14 11.5 0.1 0.16 11.3 0.1 1.0 1 0 0 1 1 1 0 Mcm10 replication factor IBR PF01485.21 EXF76578.1 - 0.029 14.6 33.0 0.03 14.5 9.7 3.5 3 0 0 3 3 3 0 IBR domain, a half RING-finger domain Rad4 PF03835.15 EXF76579.1 - 7.7e-33 113.2 0.0 3.7e-32 111.0 0.0 2.2 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain BHD_3 PF10405.9 EXF76579.1 - 7.5e-26 90.4 0.5 1.6e-25 89.3 0.5 1.6 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 3 BHD_2 PF10404.9 EXF76579.1 - 1.7e-17 64.1 0.9 1.7e-17 64.1 0.9 7.0 7 2 0 7 7 7 3 Rad4 beta-hairpin domain 2 BHD_1 PF10403.9 EXF76579.1 - 2.5e-17 62.4 0.1 5.7e-17 61.3 0.1 1.6 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 1 Transglut_core PF01841.19 EXF76579.1 - 0.0059 17.0 0.1 0.035 14.6 0.1 2.5 1 1 0 1 1 1 1 Transglutaminase-like superfamily zf-AN1 PF01428.16 EXF76580.1 - 3.4e-24 84.7 25.4 2.5e-12 46.7 6.3 2.2 2 0 0 2 2 2 2 AN1-like Zinc finger IBR PF01485.21 EXF76580.1 - 0.0074 16.5 3.5 0.0074 16.5 3.5 2.8 2 1 0 2 2 2 1 IBR domain, a half RING-finger domain DpnI PF06044.12 EXF76580.1 - 1.4 8.5 3.3 2.5 7.7 0.5 2.2 2 0 0 2 2 2 0 Dam-replacing family Remorin_C PF03763.13 EXF76580.1 - 1.4 8.8 5.9 0.16 11.9 1.5 1.7 2 0 0 2 2 2 0 Remorin, C-terminal region Transp_Tc5_C PF04236.15 EXF76580.1 - 1.6 9.1 16.2 1.8 9.0 7.0 2.3 2 0 0 2 2 2 0 Tc5 transposase C-terminal domain zf-C3HC4_2 PF13923.6 EXF76580.1 - 3.9 7.4 16.3 0.24 11.3 1.2 3.2 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) MTP18 PF10558.9 EXF76581.1 - 7.4e-82 273.4 0.1 9.3e-82 273.1 0.1 1.1 1 0 0 1 1 1 1 Mitochondrial 18 KDa protein (MTP18) ATP19 PF11022.8 EXF76582.1 - 5.4e-29 100.4 0.1 6.2e-29 100.2 0.1 1.0 1 0 0 1 1 1 1 ATP synthase subunit K adh_short PF00106.25 EXF76583.1 - 2.3e-24 85.9 0.2 5.7e-20 71.6 0.2 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EXF76583.1 - 3.5e-13 49.6 0.2 2.7e-12 46.8 0.2 1.9 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF76583.1 - 2.4e-05 24.3 0.1 3.6e-05 23.8 0.1 1.4 1 1 0 1 1 1 1 KR domain Glycos_transf_3 PF00591.21 EXF76583.1 - 0.063 12.9 0.1 0.088 12.4 0.1 1.2 1 0 0 1 1 1 0 Glycosyl transferase family, a/b domain SGL PF08450.12 EXF76584.1 - 3.6e-08 33.3 0.0 5e-08 32.8 0.0 1.2 1 0 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Arylesterase PF01731.20 EXF76584.1 - 0.0014 18.8 0.0 0.0033 17.6 0.0 1.5 1 0 0 1 1 1 1 Arylesterase NHL PF01436.21 EXF76584.1 - 0.034 14.2 0.3 9.7 6.4 0.0 2.8 2 1 0 2 2 2 0 NHL repeat Thymidylat_synt PF00303.19 EXF76586.1 - 2.7e-109 364.4 0.0 3.1e-109 364.2 0.0 1.0 1 0 0 1 1 1 1 Thymidylate synthase HTH_ABP1_N PF18107.1 EXF76587.1 - 1.5e-24 85.4 1.7 4.6e-24 83.9 1.7 1.8 1 0 0 1 1 1 1 Fission yeast centromere protein N-terminal domain HTH_Tnp_Tc5 PF03221.16 EXF76587.1 - 4.5e-18 65.1 1.2 3.7e-17 62.1 0.1 2.6 2 1 1 3 3 3 1 Tc5 transposase DNA-binding domain DUF4604 PF15377.6 EXF76587.1 - 0.041 14.3 0.1 0.073 13.5 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) DUF2868 PF11067.8 EXF76587.1 - 4.1 6.8 7.7 24 4.3 7.7 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF2868) DUF3591 PF12157.8 EXF76588.1 - 8.9e-175 581.6 1.3 1.5e-174 580.8 1.3 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3591) Actin PF00022.19 EXF76589.1 - 6.3e-147 489.4 0.0 7.1e-147 489.3 0.0 1.0 1 0 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EXF76589.1 - 6.1e-07 28.6 0.0 0.0013 17.6 0.0 2.3 2 0 0 2 2 2 2 MreB/Mbl protein PIG-P PF08510.12 EXF76590.1 - 1.6e-50 170.1 0.6 2.3e-50 169.5 0.6 1.3 1 0 0 1 1 1 1 PIG-P DPM2 PF07297.12 EXF76590.1 - 0.023 15.0 9.0 0.039 14.3 9.0 1.3 1 0 0 1 1 1 0 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) DUF485 PF04341.12 EXF76590.1 - 2.7 8.0 7.6 0.24 11.4 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function, DUF485 IBR PF01485.21 EXF76591.1 - 4.1e-08 33.3 0.3 4.1e-08 33.3 0.3 3.4 3 1 0 3 3 3 2 IBR domain, a half RING-finger domain FtsL PF04999.13 EXF76591.1 - 0.0071 16.3 0.1 0.016 15.2 0.1 1.5 1 0 0 1 1 1 1 Cell division protein FtsL zinc_ribbon_2 PF13240.6 EXF76591.1 - 0.14 11.9 0.3 0.14 11.9 0.3 4.0 4 0 0 4 4 4 0 zinc-ribbon domain zf-C3HC4_3 PF13920.6 EXF76591.1 - 0.29 11.0 23.8 0.11 12.4 10.7 3.3 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) Mito_fiss_reg PF05308.11 EXF76591.1 - 7.8 6.5 6.9 21 5.1 6.9 1.7 1 0 0 1 1 1 0 Mitochondrial fission regulator Sugar_tr PF00083.24 EXF76592.1 - 1e-121 407.0 16.9 1.3e-121 406.6 16.9 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF76592.1 - 5.1e-22 78.3 35.8 7e-18 64.7 11.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sel1 PF08238.12 EXF76593.1 - 2.6e-37 126.4 43.2 8.2e-05 23.2 0.4 12.9 13 0 0 13 13 13 8 Sel1 repeat OPA3 PF07047.12 EXF76593.1 - 0.015 15.0 0.1 0.039 13.7 0.1 1.6 1 0 0 1 1 1 0 Optic atrophy 3 protein (OPA3) TPR_7 PF13176.6 EXF76593.1 - 0.044 13.8 2.1 1.7 8.9 0.1 4.6 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_1 PF00515.28 EXF76593.1 - 0.44 10.5 7.4 2.7 8.0 0.1 5.0 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_6 PF13174.6 EXF76593.1 - 0.48 11.2 18.0 0.88 10.4 0.7 6.7 8 0 0 8 8 8 0 Tetratricopeptide repeat TPR_8 PF13181.6 EXF76593.1 - 1.8 9.0 6.9 8.5 6.9 0.1 5.2 5 1 1 6 6 6 0 Tetratricopeptide repeat AIM3 PF17096.5 EXF76593.1 - 2.8 8.9 8.8 12 6.9 0.6 2.6 2 0 0 2 2 2 0 Altered inheritance of mitochondria protein 3 TPR_2 PF07719.17 EXF76593.1 - 7.5 6.9 12.1 11 6.5 0.2 6.2 6 0 0 6 6 6 0 Tetratricopeptide repeat WD40 PF00400.32 EXF76594.1 - 4.9e-12 46.2 4.0 0.02 15.7 0.0 5.4 6 0 0 6 6 6 3 WD domain, G-beta repeat DUF4948 PF16306.5 EXF76594.1 - 0.011 15.5 0.2 0.018 14.8 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4948) Nucleoporin_N PF08801.11 EXF76594.1 - 0.017 13.9 0.0 11 4.7 0.0 3.2 2 1 0 3 3 3 0 Nup133 N terminal like FRG1 PF06229.12 EXF76595.1 - 5.7e-49 166.4 0.1 1e-48 165.6 0.1 1.3 1 0 0 1 1 1 1 FRG1-like domain Fascin PF06268.13 EXF76595.1 - 0.005 17.1 0.0 0.02 15.1 0.0 2.0 2 0 0 2 2 2 1 Fascin domain 2OG-FeII_Oxy PF03171.20 EXF76596.1 - 0.0017 18.8 0.0 0.0065 16.9 0.0 2.0 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Fungal_trans PF04082.18 EXF76598.1 - 3.8e-09 36.0 0.0 8.3e-09 34.8 0.0 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF76598.1 - 5.5e-07 29.6 9.5 1.2e-06 28.5 9.5 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FeS_assembly_P PF01883.19 EXF76599.1 - 2.3e-07 30.9 0.0 9.6e-07 28.9 0.0 2.0 1 1 0 1 1 1 1 Iron-sulfur cluster assembly protein GTP_EFTU PF00009.27 EXF76600.1 - 1.4e-45 155.2 0.0 2.1e-45 154.6 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFTUD2 PF16004.5 EXF76600.1 - 6.3e-35 120.4 3.4 1.4e-34 119.3 3.4 1.6 1 0 0 1 1 1 1 116 kDa U5 small nuclear ribonucleoprotein component N-terminus EFG_IV PF03764.18 EXF76600.1 - 8.9e-25 86.8 0.0 3.3e-24 85.0 0.0 2.1 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_C PF00679.24 EXF76600.1 - 1.3e-18 66.8 0.0 3.4e-18 65.5 0.0 1.8 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.6 EXF76600.1 - 2.6e-08 33.8 0.2 5e-07 29.7 0.0 2.5 2 0 0 2 2 2 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 EXF76600.1 - 6e-08 33.0 0.0 1.9e-07 31.4 0.0 2.0 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EXF76600.1 - 0.00023 21.2 0.1 0.00049 20.2 0.1 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase Thiolase_N PF00108.23 EXF76601.1 - 1.1e-93 313.3 2.1 1.7e-93 312.7 2.1 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EXF76601.1 - 6.8e-47 158.1 0.2 1.8e-46 156.8 0.2 1.8 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 EXF76601.1 - 4.9e-05 23.0 0.9 4.9e-05 23.0 0.9 2.1 3 0 0 3 3 3 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.10 EXF76601.1 - 0.015 15.1 1.4 1.6 8.6 0.1 2.9 3 0 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III DUF2415 PF10313.9 EXF76602.1 - 0.00073 19.4 0.0 0.0019 18.1 0.0 1.7 1 0 0 1 1 1 1 Uncharacterised protein domain (DUF2415) WD40 PF00400.32 EXF76602.1 - 0.032 15.1 1.6 0.33 11.9 0.4 3.1 3 0 0 3 3 3 0 WD domain, G-beta repeat RXT2_N PF08595.11 EXF76602.1 - 0.2 11.6 1.8 0.44 10.6 1.8 1.5 1 0 0 1 1 1 0 RXT2-like, N-terminal NOA36 PF06524.12 EXF76602.1 - 0.58 9.4 6.7 1.1 8.6 6.7 1.3 1 0 0 1 1 1 0 NOA36 protein O-FucT PF10250.9 EXF76603.1 - 6.6e-11 42.5 0.0 3.2e-10 40.3 0.0 2.0 1 1 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase Phage-tail_3 PF13550.6 EXF76603.1 - 0.0062 16.4 0.1 0.012 15.5 0.1 1.4 1 0 0 1 1 1 1 Putative phage tail protein Ppx-GppA PF02541.16 EXF76604.1 - 5.5e-27 94.9 0.0 9.7e-26 90.8 0.0 2.0 1 1 0 1 1 1 1 Ppx/GppA phosphatase family HET PF06985.11 EXF76605.1 - 1.4e-30 106.6 0.4 2.7e-30 105.6 0.4 1.5 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) MFS_1 PF07690.16 EXF76606.1 - 4.3e-30 104.8 38.5 4.3e-30 104.8 38.5 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily Peptidase_M19 PF01244.21 EXF76607.1 - 1.6e-101 339.7 0.0 1.8e-101 339.5 0.0 1.0 1 0 0 1 1 1 1 Membrane dipeptidase (Peptidase family M19) Zn_clus PF00172.18 EXF76608.1 - 0.00036 20.6 6.9 0.00082 19.4 6.9 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Questin_oxidase PF14027.6 EXF76609.1 - 4.4e-95 319.1 2.9 5.3e-95 318.8 2.9 1.1 1 0 0 1 1 1 1 Questin oxidase-like Rad17 PF03215.15 EXF76610.1 - 3e-23 82.7 0.0 6.3e-23 81.7 0.0 1.5 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_16 PF13191.6 EXF76610.1 - 0.00045 20.7 0.0 0.001 19.4 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 EXF76610.1 - 0.0028 18.1 0.0 0.0077 16.7 0.0 1.7 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) TsaE PF02367.17 EXF76610.1 - 0.0045 17.0 0.0 0.009 16.0 0.0 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_30 PF13604.6 EXF76610.1 - 0.0047 16.7 0.0 0.0097 15.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EXF76610.1 - 0.027 14.7 0.0 0.055 13.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EXF76610.1 - 0.038 14.2 0.1 0.084 13.0 0.1 1.6 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 EXF76610.1 - 0.043 12.9 0.0 0.069 12.2 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein NACHT PF05729.12 EXF76610.1 - 0.052 13.5 0.1 0.11 12.4 0.1 1.5 1 0 0 1 1 1 0 NACHT domain AAA_28 PF13521.6 EXF76610.1 - 0.087 13.1 0.0 0.17 12.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EXF76610.1 - 0.095 13.3 0.0 0.28 11.7 0.0 1.9 1 0 0 1 1 1 0 AAA domain DUF1752 PF08550.10 EXF76611.1 - 1.5e-10 40.7 7.3 1.8e-10 40.4 5.8 2.0 2 0 0 2 2 2 1 Fungal protein of unknown function (DUF1752) GOLD_2 PF13897.6 EXF76611.1 - 0.47 11.0 2.6 0.4 11.2 0.4 1.9 2 0 0 2 2 2 0 Golgi-dynamics membrane-trafficking PBP1_TM PF14812.6 EXF76611.1 - 2.4 8.6 8.4 3 8.3 3.6 2.5 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Met_10 PF02475.16 EXF76612.1 - 1.8e-72 243.3 0.1 2.7e-72 242.7 0.1 1.3 1 0 0 1 1 1 1 Met-10+ like-protein TRM PF02005.16 EXF76612.1 - 0.059 12.5 0.0 0.095 11.9 0.0 1.2 1 0 0 1 1 1 0 N2,N2-dimethylguanosine tRNA methyltransferase 2OG-FeII_Oxy_2 PF13532.6 EXF76613.1 - 2.8e-27 96.2 0.0 3.6e-27 95.8 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Prenyltransf PF01255.19 EXF76614.1 - 0.18 11.3 0.0 2 7.9 0.0 2.0 2 0 0 2 2 2 0 Putative undecaprenyl diphosphate synthase Ovate PF04844.13 EXF76615.1 - 0.16 12.0 0.1 0.37 10.8 0.1 1.6 1 0 0 1 1 1 0 Transcriptional repressor, ovate Zn_clus PF00172.18 EXF76616.1 - 1.3e-09 38.0 12.5 2.5e-09 37.1 12.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EXF76616.1 - 4.9e-08 32.2 0.0 5.9e-07 28.6 0.0 2.1 2 0 0 2 2 2 1 Fungal specific transcription factor domain PDT PF00800.18 EXF76617.1 - 4.3e-48 163.5 0.0 4.1e-46 157.1 0.0 2.1 1 1 1 2 2 2 2 Prephenate dehydratase ACT PF01842.25 EXF76617.1 - 1.9e-05 24.3 0.0 0.00015 21.4 0.0 2.3 2 1 0 2 2 2 1 ACT domain SAM_2 PF07647.17 EXF76619.1 - 2e-18 66.2 0.1 2.5e-18 65.9 0.1 1.1 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 EXF76619.1 - 8e-17 61.4 0.1 1e-16 61.1 0.1 1.1 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_4 PF18017.1 EXF76619.1 - 0.00062 19.7 0.0 0.00085 19.2 0.0 1.2 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 EXF76619.1 - 0.013 15.4 0.0 0.019 14.9 0.0 1.3 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain SAM_Ste50p PF09235.10 EXF76619.1 - 0.15 12.3 0.4 0.23 11.8 0.4 1.2 1 0 0 1 1 1 0 Ste50p, sterile alpha motif PAS_11 PF14598.6 EXF76620.1 - 0.12 12.5 0.1 0.26 11.4 0.1 1.4 1 0 0 1 1 1 0 PAS domain PGG PF13962.6 EXF76621.1 - 1.3 8.9 5.5 0.39 10.5 2.3 1.7 2 0 0 2 2 2 0 Domain of unknown function DUF4131 PF13567.6 EXF76621.1 - 9.9 5.8 6.7 9.7 5.8 1.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) DUF4646 PF15496.6 EXF76622.1 - 0.00042 20.9 1.1 0.77 10.4 0.1 2.2 1 1 1 2 2 2 2 Domain of unknown function (DUF4646) Zn_clus PF00172.18 EXF76623.1 - 8.9e-09 35.3 12.6 1.6e-08 34.6 12.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EXF76623.1 - 8e-05 21.6 0.1 0.00011 21.2 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Pkinase PF00069.25 EXF76624.1 - 2.9e-69 233.4 1.8 2.6e-68 230.2 1.8 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF76624.1 - 1e-53 182.3 0.1 2e-53 181.3 0.1 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 EXF76624.1 - 2.6e-24 85.3 0.0 8.5e-24 83.7 0.0 2.0 1 0 0 1 1 1 1 P21-Rho-binding domain Kinase-like PF14531.6 EXF76624.1 - 4.4e-07 29.5 0.0 7.1e-07 28.8 0.0 1.4 1 0 0 1 1 1 1 Kinase-like PH_11 PF15413.6 EXF76624.1 - 8e-07 29.4 0.0 2.6e-06 27.8 0.0 2.0 1 0 0 1 1 1 1 Pleckstrin homology domain Pkinase_fungal PF17667.1 EXF76624.1 - 8.2e-06 24.8 0.0 8.2e-06 24.8 0.0 1.9 2 1 0 2 2 1 1 Fungal protein kinase PH PF00169.29 EXF76624.1 - 0.0018 18.8 0.0 0.0043 17.5 0.0 1.7 1 0 0 1 1 1 1 PH domain Seadorna_VP7 PF07387.11 EXF76624.1 - 0.027 13.5 0.0 0.046 12.8 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Haspin_kinase PF12330.8 EXF76624.1 - 0.036 13.0 0.1 0.062 12.2 0.1 1.3 1 0 0 1 1 1 0 Haspin like kinase domain APH PF01636.23 EXF76624.1 - 0.061 13.2 0.2 0.061 13.2 0.2 2.4 2 1 1 3 3 3 0 Phosphotransferase enzyme family Kdo PF06293.14 EXF76624.1 - 0.094 12.1 0.0 0.2 11.0 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family KIND PF16474.5 EXF76624.1 - 0.13 12.2 0.0 0.26 11.1 0.0 1.5 1 0 0 1 1 1 0 Kinase non-catalytic C-lobe domain HGTP_anticodon PF03129.20 EXF76625.1 - 4.1e-22 78.1 2.6 5e-21 74.7 0.0 3.2 3 0 0 3 3 3 1 Anticodon binding domain tRNA-synt_2b PF00587.25 EXF76625.1 - 5.2e-08 33.1 0.0 5.6e-07 29.7 0.0 2.3 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Brix PF04427.18 EXF76626.1 - 6.5e-24 85.1 0.4 1.1e-23 84.4 0.4 1.4 1 0 0 1 1 1 1 Brix domain BUD22 PF09073.10 EXF76626.1 - 0.13 11.6 28.4 0.19 11.1 28.4 1.1 1 0 0 1 1 1 0 BUD22 Sporozoite_P67 PF05642.11 EXF76626.1 - 4.4 5.3 7.4 6.3 4.8 7.4 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Par3_HAL_N_term PF12053.8 EXF76626.1 - 8.9 6.6 9.4 3.7 7.8 3.4 2.3 1 1 1 2 2 2 0 N-terminal of Par3 and HAL proteins TPT PF03151.16 EXF76627.1 - 1.4e-05 24.6 17.6 4.5e-05 22.9 17.6 1.7 1 1 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 EXF76627.1 - 4.7e-05 23.6 12.3 4.7e-05 23.6 12.3 2.3 2 0 0 2 2 2 1 EamA-like transporter family UPF0139 PF03669.13 EXF76627.1 - 0.018 14.9 0.2 0.07 13.0 0.2 2.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0139) CRPA PF05745.11 EXF76627.1 - 3.2 7.7 6.0 0.8 9.7 0.3 2.6 3 0 0 3 3 3 0 Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA) GDP_Man_Dehyd PF16363.5 EXF76628.1 - 1.3e-69 235.2 0.0 1.5e-69 235.0 0.0 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 EXF76628.1 - 4e-57 193.4 0.0 5e-57 193.1 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EXF76628.1 - 5.6e-24 84.8 0.0 8.1e-23 81.0 0.0 2.0 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.19 EXF76628.1 - 8.7e-19 67.6 0.0 1.1e-18 67.2 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 EXF76628.1 - 1.2e-18 67.2 0.1 1.8e-17 63.4 0.1 2.1 1 1 0 1 1 1 1 Male sterility protein RmlD_sub_bind PF04321.17 EXF76628.1 - 6.5e-17 61.5 0.0 8.5e-17 61.2 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_10 PF13460.6 EXF76628.1 - 1.2e-07 31.8 0.0 2.2e-07 31.0 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding adh_short PF00106.25 EXF76628.1 - 0.2 11.1 0.0 1.6 8.2 0.1 2.1 2 0 0 2 2 2 0 short chain dehydrogenase Methyltransf_23 PF13489.6 EXF76629.1 - 2.3e-14 53.6 0.0 3.9e-14 52.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF76629.1 - 2.4e-10 41.0 0.0 7.5e-10 39.4 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF76629.1 - 9.4e-08 32.7 0.0 2.6e-07 31.3 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF76629.1 - 2.8e-07 30.4 0.0 2.2e-06 27.5 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF76629.1 - 5.6e-07 30.1 0.0 1.6e-06 28.7 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EXF76629.1 - 5.9e-05 22.5 0.0 0.00047 19.6 0.0 2.2 2 1 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.17 EXF76629.1 - 0.0021 17.6 0.0 0.0036 16.8 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase MTS PF05175.14 EXF76629.1 - 0.0032 17.0 0.0 0.0068 16.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_2 PF00891.18 EXF76629.1 - 0.0057 16.0 0.0 0.017 14.4 0.0 1.8 2 0 0 2 2 2 1 O-methyltransferase domain DUF938 PF06080.12 EXF76629.1 - 0.15 11.8 0.0 0.26 11.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF938) Terminase_1 PF03354.15 EXF76629.1 - 0.2 10.2 0.0 0.29 9.7 0.0 1.1 1 0 0 1 1 1 0 Phage Terminase Pep3_Vps18 PF05131.14 EXF76630.1 - 5.3e-48 162.6 0.0 1.3e-47 161.4 0.0 1.7 2 0 0 2 2 2 1 Pep3/Vps18/deep orange family Clathrin PF00637.20 EXF76630.1 - 3.6e-11 43.1 2.6 4.8e-09 36.2 0.1 3.2 3 0 0 3 3 3 1 Region in Clathrin and VPS zf-C3HC4_2 PF13923.6 EXF76630.1 - 0.00037 20.3 0.6 0.00081 19.2 0.6 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) DUF2175 PF09943.9 EXF76630.1 - 0.00065 19.9 0.0 0.0021 18.3 0.0 1.9 1 0 0 1 1 1 1 Uncharacterized protein conserved in archaea (DUF2175) zf-RING_5 PF14634.6 EXF76630.1 - 0.0011 18.9 0.4 0.0011 18.9 0.4 1.7 2 0 0 2 2 1 1 zinc-RING finger domain Zn_ribbon_17 PF17120.5 EXF76630.1 - 0.0015 18.2 0.1 0.003 17.1 0.1 1.5 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-RING_2 PF13639.6 EXF76630.1 - 0.003 17.8 0.5 0.0081 16.5 0.5 1.7 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 EXF76630.1 - 0.011 15.7 0.6 0.027 14.5 0.6 1.6 1 0 0 1 1 1 0 RING-type zinc-finger Vps39_2 PF10367.9 EXF76630.1 - 0.053 14.0 0.0 0.17 12.3 0.0 2.0 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 2 zf-rbx1 PF12678.7 EXF76630.1 - 0.14 12.5 0.2 0.33 11.3 0.2 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger domain UCH PF00443.29 EXF76630.1 - 0.18 11.3 0.1 0.27 10.7 0.1 1.3 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase zf-C3H2C3 PF17122.5 EXF76630.1 - 0.35 10.9 6.9 0.048 13.7 2.5 1.8 2 0 0 2 2 2 0 Zinc-finger zf-C3HC4 PF00097.25 EXF76630.1 - 0.5 10.3 3.0 0.25 11.3 0.2 1.9 2 0 0 2 2 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EXF76630.1 - 1.2 9.0 11.2 0.049 13.4 4.3 2.2 2 0 0 2 2 2 0 RING-like zinc finger p450 PF00067.22 EXF76631.1 - 3e-74 250.4 0.0 4.3e-74 249.9 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 Phe_tRNA-synt_N PF02912.18 EXF76631.1 - 0.063 13.2 0.3 0.11 12.4 0.3 1.4 1 0 0 1 1 1 0 Aminoacyl tRNA synthetase class II, N-terminal domain Abhydrolase_6 PF12697.7 EXF76632.1 - 4.7e-22 79.7 1.6 4.7e-22 79.7 1.6 1.4 2 0 0 2 2 2 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EXF76632.1 - 4.9e-07 29.2 0.0 8.1e-07 28.5 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EXF76632.1 - 4.5e-06 26.5 0.7 0.047 13.3 0.3 3.1 2 1 0 2 2 2 2 alpha/beta hydrolase fold Thioesterase PF00975.20 EXF76632.1 - 0.008 16.3 0.0 0.026 14.6 0.0 1.8 1 1 0 1 1 1 1 Thioesterase domain PGAP1 PF07819.13 EXF76632.1 - 0.078 12.7 0.0 0.12 12.1 0.0 1.2 1 0 0 1 1 1 0 PGAP1-like protein TRP PF06011.12 EXF76633.1 - 4.1e-145 483.8 13.0 5e-145 483.5 13.0 1.1 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.6 EXF76633.1 - 3.8e-40 137.5 4.6 6.8e-40 136.6 4.6 1.4 1 0 0 1 1 1 1 ML-like domain SRF-TF PF00319.18 EXF76636.1 - 1.4e-22 78.9 0.3 2.2e-22 78.3 0.3 1.3 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) zf-C2H2 PF00096.26 EXF76637.1 - 0.5 10.9 7.4 1.1 9.8 0.2 2.9 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EXF76637.1 - 0.72 10.8 7.0 9.3 7.4 0.3 3.1 3 0 0 3 3 3 0 C2H2-type zinc finger Fasciclin PF02469.22 EXF76638.1 - 3.4e-24 85.5 0.2 8.7e-17 61.5 0.0 2.3 2 0 0 2 2 2 2 Fasciclin domain SOG2 PF10428.9 EXF76639.1 - 2 7.5 7.6 2.5 7.2 7.6 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein GFA PF04828.14 EXF76640.1 - 7.1e-25 87.2 0.0 1e-24 86.7 0.0 1.2 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme DZR PF12773.7 EXF76640.1 - 0.12 12.4 3.5 0.85 9.7 0.2 2.5 2 1 0 2 2 2 0 Double zinc ribbon DUF1365 PF07103.11 EXF76641.1 - 6.6e-61 206.0 0.0 9e-61 205.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1365) UPF0029 PF01205.19 EXF76643.1 - 4.9e-25 87.9 0.0 1.1e-24 86.7 0.0 1.7 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 Methyltransf_23 PF13489.6 EXF76643.1 - 4.9e-18 65.5 0.0 9.5e-18 64.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF76643.1 - 5.5e-05 23.0 0.0 0.04 13.7 0.0 2.4 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 EXF76643.1 - 0.0003 21.5 0.0 0.0023 18.6 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF76643.1 - 0.0012 19.5 0.0 0.028 15.0 0.0 2.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF76643.1 - 0.0012 19.5 0.0 0.81 10.4 0.1 3.5 2 1 0 2 2 2 1 Methyltransferase domain Seipin PF06775.14 EXF76644.1 - 4.5e-54 183.6 0.1 6.7e-54 183.0 0.1 1.3 1 0 0 1 1 1 1 Putative adipose-regulatory protein (Seipin) Cwf_Cwc_15 PF04889.12 EXF76644.1 - 3.7 7.2 9.5 1.3 8.7 1.4 2.4 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Not1 PF04054.15 EXF76645.1 - 1.3e-122 409.3 0.0 2.9e-122 408.1 0.0 1.6 1 0 0 1 1 1 1 CCR4-Not complex component, Not1 CNOT1_CAF1_bind PF16415.5 EXF76645.1 - 2e-92 308.6 2.7 2e-92 308.6 2.7 1.8 2 0 0 2 2 2 1 CCR4-NOT transcription complex subunit 1 CAF1-binding domain DUF3819 PF12842.7 EXF76645.1 - 2.6e-49 166.9 1.8 2.6e-49 166.9 1.8 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF3819) CNOT1_TTP_bind PF16417.5 EXF76645.1 - 3.1e-42 143.9 0.0 9.2e-42 142.4 0.0 1.7 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 1 TTP binding domain CNOT1_HEAT PF16418.5 EXF76645.1 - 1e-38 132.8 5.5 1.6e-38 132.2 1.2 2.7 2 0 0 2 2 2 1 CCR4-NOT transcription complex subunit 1 HEAT repeat SH3_1 PF00018.28 EXF76646.1 - 2.3e-12 46.3 0.0 4.2e-12 45.5 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 EXF76646.1 - 7.3e-12 44.8 0.0 1.4e-10 40.7 0.0 2.5 2 0 0 2 2 2 1 Variant SH3 domain SH3_9 PF14604.6 EXF76646.1 - 3.5e-11 42.8 0.0 7.1e-11 41.8 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain FCH PF00611.23 EXF76646.1 - 4.6e-11 42.9 0.0 9.6e-11 41.8 0.0 1.6 1 0 0 1 1 1 1 Fes/CIP4, and EFC/F-BAR homology domain ApoLp-III PF07464.11 EXF76646.1 - 1.8 8.6 8.2 4.7 7.3 0.5 3.0 3 0 0 3 3 3 0 Apolipophorin-III precursor (apoLp-III) DOPA_dioxygen PF08883.11 EXF76647.1 - 1.5e-42 144.1 0.4 2.9e-42 143.2 0.4 1.4 1 1 0 1 1 1 1 Dopa 4,5-dioxygenase family Rad4 PF03835.15 EXF76648.1 - 7.2e-32 110.1 0.6 1.9e-31 108.7 0.6 1.7 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain BHD_3 PF10405.9 EXF76648.1 - 8.3e-28 96.6 0.4 1.8e-27 95.5 0.4 1.6 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 3 BHD_1 PF10403.9 EXF76648.1 - 5.5e-22 77.4 0.0 1.3e-21 76.1 0.0 1.7 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 1 BHD_2 PF10404.9 EXF76648.1 - 3.9e-15 56.6 0.1 3.9e-15 56.6 0.1 3.9 2 1 0 2 2 2 1 Rad4 beta-hairpin domain 2 Transglut_core PF01841.19 EXF76648.1 - 0.0006 20.2 0.2 0.0067 16.9 0.2 2.8 1 1 0 1 1 1 1 Transglutaminase-like superfamily DNA_pol_phi PF04931.13 EXF76648.1 - 0.2 9.7 6.5 0.39 8.8 6.5 1.5 1 0 0 1 1 1 0 DNA polymerase phi RRN3 PF05327.11 EXF76648.1 - 2.7 6.4 6.5 4.4 5.7 6.5 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Zn_clus PF00172.18 EXF76649.1 - 2.6e-10 40.2 12.0 4e-10 39.7 12.0 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EXF76649.1 - 0.0077 15.3 0.0 0.017 14.1 0.0 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Dicty_REP PF05086.12 EXF76649.1 - 1.2 7.0 2.1 1.7 6.5 2.1 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Copper-fist PF00649.18 EXF76650.1 - 2.5e-22 78.1 2.9 2.5e-22 78.1 2.9 4.2 1 1 3 4 4 4 1 Copper fist DNA binding domain Leu_leader PF08054.11 EXF76650.1 - 0.19 11.3 0.2 7.1 6.3 0.1 2.3 2 0 0 2 2 2 0 Leucine operon leader peptide ApbA PF02558.16 EXF76652.1 - 1.2e-34 119.1 0.0 1.6e-34 118.7 0.0 1.2 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA ApbA_C PF08546.11 EXF76652.1 - 3.4e-26 91.9 0.0 5.3e-26 91.3 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal GFO_IDH_MocA PF01408.22 EXF76652.1 - 0.044 14.6 0.0 0.086 13.7 0.0 1.5 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold PHY PF00360.20 EXF76653.1 - 1.2e-27 96.5 0.0 3.4e-27 94.9 0.0 1.7 2 0 0 2 2 2 1 Phytochrome region HATPase_c PF02518.26 EXF76653.1 - 2.5e-20 73.0 0.1 5.9e-20 71.8 0.1 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EXF76653.1 - 1.2e-17 64.1 0.0 6.4e-17 61.7 0.0 2.1 1 1 0 1 1 1 1 Response regulator receiver domain GAF PF01590.26 EXF76653.1 - 7.7e-13 49.2 0.0 2.2e-12 47.8 0.0 1.8 1 0 0 1 1 1 1 GAF domain HisKA PF00512.25 EXF76653.1 - 1.5e-12 47.4 0.7 6e-12 45.4 0.7 2.1 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain PAS_2 PF08446.11 EXF76653.1 - 1e-07 32.6 0.0 3.8e-07 30.7 0.0 2.0 2 0 0 2 2 2 1 PAS fold HATPase_c_3 PF13589.6 EXF76653.1 - 0.023 14.5 0.0 0.05 13.4 0.0 1.6 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase SLATT_5 PF18160.1 EXF76654.1 - 2 7.7 6.1 6 6.2 0.1 2.9 2 1 1 3 3 3 0 SMODS and SLOG-associating 2TM effector domain family 5 ABC_tran PF00005.27 EXF76655.1 - 1.4e-46 158.4 0.5 6.3e-25 88.3 0.0 2.6 2 0 0 2 2 2 2 ABC transporter ABC2_membrane_3 PF12698.7 EXF76655.1 - 1.9e-22 79.9 43.1 1.2e-14 54.2 19.1 2.9 2 1 0 2 2 2 2 ABC-2 family transporter protein AAA_21 PF13304.6 EXF76655.1 - 1.3e-18 67.9 3.9 2.4e-05 24.3 0.0 4.5 3 1 1 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EXF76655.1 - 2e-08 33.9 2.5 0.0013 18.4 0.3 3.7 4 0 0 4 4 3 2 P-loop containing region of AAA domain SMC_N PF02463.19 EXF76655.1 - 1.3e-06 28.1 3.5 0.25 10.8 0.0 3.6 4 0 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EXF76655.1 - 4.6e-06 27.3 4.6 0.043 14.3 0.3 2.3 2 0 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 EXF76655.1 - 6e-05 23.0 1.7 0.11 12.4 0.1 2.4 2 0 0 2 2 2 2 RsgA GTPase AAA_15 PF13175.6 EXF76655.1 - 0.00049 19.9 0.2 1.2 8.8 0.3 3.2 3 0 0 3 3 3 1 AAA ATPase domain ABC2_membrane PF01061.24 EXF76655.1 - 0.00073 19.0 15.4 0.00073 19.0 15.4 4.0 3 1 0 3 3 3 1 ABC-2 type transporter DUF4162 PF13732.6 EXF76655.1 - 0.0035 18.0 0.0 3.5 8.4 0.0 2.9 3 0 0 3 3 2 1 Domain of unknown function (DUF4162) AAA_27 PF13514.6 EXF76655.1 - 0.0038 16.8 0.1 0.78 9.3 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EXF76655.1 - 0.0048 17.3 0.3 2.7 8.4 0.1 2.8 2 0 0 2 2 2 1 AAA ATPase domain AAA_30 PF13604.6 EXF76655.1 - 0.0052 16.5 0.3 4.3 7.0 0.0 2.7 2 0 0 2 2 2 2 AAA domain Rad17 PF03215.15 EXF76655.1 - 0.0053 16.7 0.0 2.3 8.1 0.0 2.4 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_22 PF13401.6 EXF76655.1 - 0.0092 16.3 0.1 3.9 7.7 0.0 2.9 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 EXF76655.1 - 0.011 15.0 0.5 5 6.3 0.3 2.5 2 0 0 2 2 2 0 Zeta toxin RNA_helicase PF00910.22 EXF76655.1 - 0.024 15.0 0.0 1.3 9.4 0.0 2.5 2 0 0 2 2 2 0 RNA helicase SRP54 PF00448.22 EXF76655.1 - 0.052 13.2 1.3 10 5.7 0.9 2.3 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_PrkA PF08298.11 EXF76655.1 - 0.07 12.0 0.0 3.9 6.3 0.0 2.2 2 0 0 2 2 2 0 PrkA AAA domain AAA_24 PF13479.6 EXF76655.1 - 0.076 12.7 0.2 12 5.5 0.1 2.3 2 0 0 2 2 2 0 AAA domain DUF87 PF01935.17 EXF76655.1 - 0.098 12.7 2.1 2.5 8.1 0.0 2.7 3 0 0 3 3 2 0 Helicase HerA, central domain MukB PF04310.12 EXF76655.1 - 0.16 11.7 0.4 9.6 5.9 0.0 2.5 2 0 0 2 2 2 0 MukB N-terminal AAA_28 PF13521.6 EXF76655.1 - 0.69 10.1 3.7 81 3.4 2.9 3.1 3 0 0 3 3 3 0 AAA domain SET PF00856.28 EXF76656.1 - 0.052 13.9 0.1 0.56 10.6 0.0 2.2 2 1 0 2 2 2 0 SET domain Nup96 PF12110.8 EXF76657.1 - 2.3e-96 322.4 2.2 3.2e-96 321.9 2.2 1.2 1 0 0 1 1 1 1 Nuclear protein 96 Nucleoporin2 PF04096.14 EXF76657.1 - 7.9e-52 175.3 0.0 1.4e-51 174.5 0.0 1.4 1 0 0 1 1 1 1 Nucleoporin autopeptidase Nucleoporin_FG PF13634.6 EXF76657.1 - 4.2e-14 53.2 345.8 3.3e-05 24.7 39.4 11.6 2 1 7 9 9 9 6 Nucleoporin FG repeat region ENTH PF01417.20 EXF76658.1 - 1.4e-50 170.5 0.1 2.4e-50 169.8 0.1 1.4 1 0 0 1 1 1 1 ENTH domain DUF1720 PF08226.11 EXF76658.1 - 8.7e-05 22.9 19.0 8.7e-05 22.9 19.0 6.3 2 1 1 3 3 3 1 Domain of unknown function (DUF1720) UIM PF02809.20 EXF76658.1 - 0.0013 18.6 4.1 0.0024 17.7 0.2 2.7 2 1 0 2 2 2 1 Ubiquitin interaction motif ANTH PF07651.16 EXF76658.1 - 0.0042 16.1 0.0 0.0063 15.5 0.0 1.2 1 0 0 1 1 1 1 ANTH domain VHS PF00790.19 EXF76658.1 - 0.031 14.1 0.0 0.058 13.3 0.0 1.4 1 0 0 1 1 1 0 VHS domain DUF4264 PF14084.6 EXF76658.1 - 0.1 12.2 0.0 0.19 11.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4264) MOZ_SAS PF01853.18 EXF76659.1 - 1.1e-74 249.9 0.0 1.7e-74 249.4 0.0 1.2 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 EXF76659.1 - 7.4e-21 73.5 3.1 1.5e-20 72.6 3.1 1.5 1 0 0 1 1 1 1 MYST family zinc finger domain PHD_4 PF16866.5 EXF76659.1 - 2.4e-07 30.7 8.6 2.4e-07 30.7 8.6 1.9 2 0 0 2 2 2 1 PHD-finger PHD PF00628.29 EXF76659.1 - 0.006 16.4 9.0 0.006 16.4 9.0 2.2 2 0 0 2 2 2 1 PHD-finger Acetyltransf_7 PF13508.7 EXF76659.1 - 0.18 12.3 0.0 0.37 11.3 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain zf-RING_9 PF13901.6 EXF76659.1 - 2.3 8.2 6.0 4.2 7.3 6.0 1.4 1 0 0 1 1 1 0 Putative zinc-RING and/or ribbon zf-4CXXC_R1 PF10497.9 EXF76659.1 - 6.7 7.0 9.0 0.55 10.5 3.9 1.8 2 0 0 2 2 2 0 Zinc-finger domain of monoamine-oxidase A repressor R1 MWFE PF15879.5 EXF76660.1 - 4.7e-22 77.9 0.1 4.7e-22 77.9 0.1 1.1 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase MWFE subunit ATP_bind_3 PF01171.20 EXF76661.1 - 3.2e-17 62.9 0.0 5.2e-17 62.2 0.0 1.3 1 0 0 1 1 1 1 PP-loop family zn-ribbon_14 PF16503.5 EXF76661.1 - 1.2e-16 59.9 17.7 2.4e-16 58.9 4.2 4.0 4 0 0 4 4 4 2 Zinc-ribbon RecR PF02132.15 EXF76661.1 - 0.024 14.2 0.5 0.024 14.2 0.5 2.9 4 0 0 4 4 4 0 RecR protein GATA PF00320.27 EXF76661.1 - 0.06 13.0 0.6 0.06 13.0 0.6 3.4 3 1 0 3 3 3 0 GATA zinc finger zf-UBR PF02207.20 EXF76661.1 - 0.12 12.6 5.4 2.6 8.3 0.3 2.8 2 0 0 2 2 2 0 Putative zinc finger in N-recognin (UBR box) Ribosomal_L7Ae PF01248.26 EXF76662.1 - 1.2e-20 73.1 0.2 2e-20 72.3 0.2 1.4 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Pro_CA PF00484.19 EXF76663.1 - 3.2e-47 160.7 0.6 3.9e-47 160.4 0.6 1.1 1 0 0 1 1 1 1 Carbonic anhydrase DUF2849 PF11011.8 EXF76663.1 - 0.023 15.3 0.1 0.046 14.4 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2849) NTF2 PF02136.20 EXF76664.1 - 2.7e-31 108.6 0.2 3e-31 108.5 0.2 1.0 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain DUF4440 PF14534.6 EXF76664.1 - 0.014 15.8 0.0 0.017 15.5 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4440) DUF4518 PF15008.6 EXF76664.1 - 0.11 11.7 0.5 0.69 9.0 0.5 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4518) Glyco_hydro_43 PF04616.14 EXF76665.1 - 1.1e-27 97.2 8.5 3.4e-20 72.5 4.0 2.2 1 1 1 2 2 2 2 Glycosyl hydrolases family 43 GH43_C2 PF17851.1 EXF76665.1 - 1.1e-16 61.1 0.2 5.3e-15 55.7 0.2 2.6 1 1 0 1 1 1 1 Beta xylosidase C-terminal Concanavalin A-like domain CK_II_beta PF01214.18 EXF76666.1 - 4.7e-74 248.1 0.0 8.6e-74 247.3 0.0 1.4 1 1 0 1 1 1 1 Casein kinase II regulatory subunit RRN3 PF05327.11 EXF76666.1 - 0.0085 14.7 1.4 0.012 14.1 1.4 1.2 1 0 0 1 1 1 1 RNA polymerase I specific transcription initiation factor RRN3 Spt5_N PF11942.8 EXF76666.1 - 1.4 9.9 16.6 0.44 11.6 9.3 2.5 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal Importin_rep_4 PF18808.1 EXF76666.1 - 5.2 7.4 10.0 7.3 6.9 3.1 2.5 2 0 0 2 2 2 0 Importin repeat DNA_pol_phi PF04931.13 EXF76666.1 - 5.3 5.0 8.0 9.6 4.2 8.0 1.3 1 0 0 1 1 1 0 DNA polymerase phi Pox_Ag35 PF03286.14 EXF76666.1 - 5.7 6.7 10.1 10 5.9 5.1 2.2 2 0 0 2 2 2 0 Pox virus Ag35 surface protein Cupin_8 PF13621.6 EXF76667.1 - 2.9e-26 92.7 0.0 3.2e-26 92.6 0.0 1.2 1 0 0 1 1 1 1 Cupin-like domain JmjC PF02373.22 EXF76667.1 - 0.0038 17.7 0.0 0.33 11.4 0.0 2.6 2 1 0 2 2 2 1 JmjC domain, hydroxylase Cupin_4 PF08007.12 EXF76667.1 - 0.035 13.6 0.0 0.057 12.9 0.0 1.3 1 0 0 1 1 1 0 Cupin superfamily protein p450 PF00067.22 EXF76668.1 - 4.5e-48 164.1 0.0 5.5e-48 163.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DNA_pol3_finger PF17657.1 EXF76668.1 - 0.1 12.0 0.0 0.16 11.3 0.0 1.3 1 0 0 1 1 1 0 Bacterial DNA polymerase III alpha subunit finger domain PEPCK_ATP PF01293.20 EXF76670.1 - 3.7e-217 721.6 0.0 4.3e-217 721.3 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase AAA_16 PF13191.6 EXF76670.1 - 0.075 13.4 0.0 0.13 12.7 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain AAA_33 PF13671.6 EXF76670.1 - 0.19 11.9 0.0 0.34 11.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain GTP_EFTU PF00009.27 EXF76671.1 - 3.1e-43 147.6 0.0 5e-43 146.9 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EXF76671.1 - 1.6e-29 102.4 1.0 4.2e-29 101.1 0.0 2.2 3 0 0 3 3 3 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EXF76671.1 - 3.6e-09 36.9 1.8 6.3e-09 36.1 0.6 2.1 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EXF76671.1 - 0.0016 18.5 0.0 0.012 15.7 0.0 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase Ran-binding PF05508.11 EXF76672.1 - 1.6e-116 388.7 0.0 2e-116 388.4 0.0 1.1 1 0 0 1 1 1 1 RanGTP-binding protein HTH_11 PF08279.12 EXF76672.1 - 0.25 11.3 0.7 1.1 9.2 0.1 2.3 2 0 0 2 2 2 0 HTH domain SNF2_N PF00176.23 EXF76673.1 - 2.6e-67 227.0 4.0 1.9e-65 220.9 4.0 2.8 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EXF76673.1 - 4.6e-18 65.6 0.1 5.5e-17 62.1 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EXF76673.1 - 9.3e-06 25.7 0.0 2.6e-05 24.3 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EXF76673.1 - 9.9e-06 25.4 0.0 2.5e-05 24.1 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase DZR PF12773.7 EXF76673.1 - 0.23 11.5 0.6 0.5 10.4 0.6 1.5 1 0 0 1 1 1 0 Double zinc ribbon PI3K_1B_p101 PF10486.9 EXF76673.1 - 2.1 6.0 7.8 3.9 5.1 7.8 1.4 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit VHS PF00790.19 EXF76674.1 - 5.3e-36 123.6 0.0 1.2e-35 122.4 0.0 1.6 1 0 0 1 1 1 1 VHS domain SH3_1 PF00018.28 EXF76674.1 - 1.3e-16 59.9 0.1 3.4e-16 58.6 0.1 1.8 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EXF76674.1 - 6.2e-15 54.8 0.9 1.1e-14 54.0 0.1 1.9 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.17 EXF76674.1 - 5.4e-14 51.6 0.0 1.2e-13 50.5 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain GAT PF03127.14 EXF76674.1 - 4.3e-10 39.8 1.7 4.3e-10 39.8 1.7 1.9 2 0 0 2 2 2 1 GAT domain UIM PF02809.20 EXF76674.1 - 0.0027 17.5 3.3 0.008 16.0 3.3 1.9 1 0 0 1 1 1 1 Ubiquitin interaction motif DUF3361 PF11841.8 EXF76674.1 - 0.23 11.4 0.2 0.46 10.4 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3361) ATG13 PF10033.9 EXF76675.1 - 1.1e-77 261.0 0.0 1.7e-77 260.3 0.0 1.3 1 0 0 1 1 1 1 Autophagy-related protein 13 RCC1 PF00415.18 EXF76676.1 - 2.3e-21 76.1 1.7 1.1e-06 29.2 0.3 5.3 5 0 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat BTB PF00651.31 EXF76676.1 - 5.3e-14 52.4 0.0 4.1e-08 33.4 0.0 2.5 2 0 0 2 2 2 2 BTB/POZ domain Ank_4 PF13637.6 EXF76676.1 - 5.1e-10 39.7 0.3 3.4e-09 37.1 0.2 2.4 1 1 1 2 2 2 1 Ankyrin repeats (many copies) RCC1_2 PF13540.6 EXF76676.1 - 3.2e-08 33.1 0.7 3.2e-08 33.1 0.7 3.9 3 0 0 3 3 3 1 Regulator of chromosome condensation (RCC1) repeat Ank_2 PF12796.7 EXF76676.1 - 1.8e-06 28.4 0.1 5.1e-06 27.0 0.1 1.8 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EXF76676.1 - 2.9e-05 24.1 0.3 0.37 11.5 0.1 3.1 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.6 EXF76676.1 - 0.015 15.6 0.1 0.26 11.7 0.0 3.1 4 0 0 4 4 4 0 Ankyrin repeats (many copies) Mito_carr PF00153.27 EXF76677.1 - 5.8e-67 221.7 1.3 2.3e-24 85.2 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Antimicrobial_8 PF08103.11 EXF76677.1 - 0.026 14.7 2.4 9.1 6.6 0.1 3.6 3 0 0 3 3 3 0 Uperin family Tim17 PF02466.19 EXF76677.1 - 0.12 12.7 2.6 0.56 10.6 2.6 2.4 1 1 0 1 1 1 0 Tim17/Tim22/Tim23/Pmp24 family BUD22 PF09073.10 EXF76679.1 - 3.9e-94 316.4 70.8 2.3e-92 310.6 70.8 2.2 1 1 0 1 1 1 1 BUD22 adh_short_C2 PF13561.6 EXF76680.1 - 1.2e-40 139.6 0.6 4.5e-39 134.4 0.6 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF76680.1 - 5.9e-36 123.8 0.2 1.2e-35 122.8 0.2 1.4 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EXF76680.1 - 2.5e-11 43.8 0.1 4.2e-11 43.1 0.1 1.4 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EXF76680.1 - 0.012 14.7 0.1 0.026 13.6 0.0 1.5 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein Pyr_redox PF00070.27 EXF76680.1 - 0.018 15.6 0.7 0.037 14.6 0.7 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Epimerase PF01370.21 EXF76680.1 - 0.097 12.1 0.0 0.19 11.1 0.0 1.5 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family Shikimate_DH PF01488.20 EXF76680.1 - 0.2 11.7 0.1 0.38 10.8 0.1 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase UCH_1 PF13423.6 EXF76681.1 - 1.3e-99 333.8 0.0 1.9e-99 333.3 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RNase_T PF00929.24 EXF76681.1 - 7.7e-22 78.6 0.0 1.3e-21 77.8 0.0 1.4 1 0 0 1 1 1 1 Exonuclease UCH PF00443.29 EXF76681.1 - 0.0056 16.2 0.0 0.011 15.2 0.0 1.5 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ANAPC4_WD40 PF12894.7 EXF76681.1 - 0.007 16.6 0.1 4.3 7.7 0.0 3.0 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain LIP1 PF15904.5 EXF76681.1 - 0.025 14.9 1.0 1.5 9.2 0.0 3.1 3 0 0 3 3 3 0 LKB1 serine/threonine kinase interacting protein 1 Collagen PF01391.18 EXF76682.1 - 7.5e-10 38.4 33.6 8.4e-08 31.9 19.2 2.5 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) Mito_carr PF00153.27 EXF76683.1 - 1.6e-51 172.2 5.1 1.7e-18 66.3 0.2 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 EXF76683.1 - 0.046 12.9 1.5 0.098 11.8 0.1 2.2 2 1 0 2 2 2 0 Gammaproteobacterial serine protease DUF3611 PF12263.8 EXF76683.1 - 1.1 9.2 5.2 0.19 11.6 0.2 2.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3611) TCO89 PF10452.9 EXF76684.1 - 9.9e-06 24.8 1.2 0.00023 20.3 0.1 3.2 3 0 0 3 3 3 2 TORC1 subunit TCO89 Tudor_3 PF18115.1 EXF76685.1 - 1.4e-06 28.1 0.0 2.2e-06 27.4 0.0 1.4 1 0 0 1 1 1 1 DNA repair protein Crb2 Tudor domain IL11 PF07400.11 EXF76685.1 - 0.015 15.0 0.2 0.022 14.4 0.2 1.3 1 0 0 1 1 1 0 Interleukin 11 DUF4537 PF15057.6 EXF76685.1 - 0.018 15.1 0.0 0.033 14.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4537) FlxA PF14282.6 EXF76685.1 - 0.033 14.2 0.3 0.033 14.2 0.3 2.0 2 1 0 2 2 2 0 FlxA-like protein LBR_tudor PF09465.10 EXF76685.1 - 0.092 12.6 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 Lamin-B receptor of TUDOR domain ABC_tran_CTD PF16326.5 EXF76685.1 - 6.2 7.1 9.2 3.3 8.0 2.0 2.6 2 0 0 2 2 2 0 ABC transporter C-terminal domain ParA PF10609.9 EXF76686.1 - 3.5e-96 321.4 0.1 4e-96 321.2 0.1 1.0 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 EXF76686.1 - 8.5e-11 42.0 0.0 3.1e-10 40.2 0.0 2.0 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 EXF76686.1 - 2.5e-09 37.3 0.6 2.9e-07 30.6 0.1 2.1 1 1 0 2 2 2 1 AAA domain ArsA_ATPase PF02374.15 EXF76686.1 - 3.7e-05 23.1 0.2 0.0023 17.2 0.0 2.8 2 1 1 3 3 3 1 Anion-transporting ATPase MipZ PF09140.11 EXF76686.1 - 0.00016 21.0 0.0 0.00021 20.7 0.0 1.2 1 0 0 1 1 1 1 ATPase MipZ Fer4_NifH PF00142.18 EXF76686.1 - 0.00071 19.1 0.0 0.087 12.3 0.0 2.3 2 1 0 2 2 2 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family AAA_26 PF13500.6 EXF76686.1 - 0.0018 18.2 0.7 0.07 12.9 0.0 2.2 2 0 0 2 2 2 1 AAA domain CBP_BcsQ PF06564.12 EXF76686.1 - 0.0024 17.4 0.3 0.023 14.2 0.1 2.0 2 0 0 2 2 2 1 Cellulose biosynthesis protein BcsQ AAA_25 PF13481.6 EXF76686.1 - 0.053 13.1 0.6 0.11 12.1 0.0 1.7 2 0 0 2 2 2 0 AAA domain Zn_Tnp_IS1595 PF12760.7 EXF76686.1 - 0.12 12.4 0.4 0.25 11.4 0.4 1.4 1 0 0 1 1 1 0 Transposase zinc-ribbon domain CLP1_P PF16575.5 EXF76686.1 - 0.17 11.7 0.0 0.33 10.7 0.0 1.4 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop MeaB PF03308.16 EXF76686.1 - 0.43 9.5 1.9 0.28 10.1 0.2 1.5 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB EF-hand_7 PF13499.6 EXF76687.1 - 2.1e-10 40.9 0.0 8e-08 32.6 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 EXF76687.1 - 6.4e-09 34.7 0.0 0.036 13.6 0.0 3.3 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.6 EXF76687.1 - 8.4e-07 28.4 0.0 0.14 12.2 0.0 3.4 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.6 EXF76687.1 - 7.3e-05 22.5 0.0 0.00016 21.4 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_4 PF12763.7 EXF76687.1 - 0.0005 20.0 0.0 0.029 14.3 0.0 2.1 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand Phage_ABA_S PF18066.1 EXF76687.1 - 0.057 14.1 0.0 1.1 10.0 0.0 2.2 2 0 0 2 2 2 0 Phage ABA sandwich domain GFO_IDH_MocA PF01408.22 EXF76688.1 - 1.7e-21 77.3 0.0 3.6e-21 76.2 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Semialdhyde_dh PF01118.24 EXF76688.1 - 0.028 14.9 0.0 0.1 13.0 0.0 1.8 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain F_bP_aldolase PF01116.20 EXF76689.1 - 7.6e-91 304.5 0.0 9.4e-91 304.2 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II Chal_sti_synt_C PF02797.15 EXF76690.1 - 1.6e-21 76.9 0.0 3.3e-21 75.9 0.0 1.5 1 0 0 1 1 1 1 Chalcone and stilbene synthases, C-terminal domain Chal_sti_synt_N PF00195.19 EXF76690.1 - 4.4e-21 75.3 0.3 6.8e-21 74.7 0.3 1.2 1 0 0 1 1 1 1 Chalcone and stilbene synthases, N-terminal domain FAE1_CUT1_RppA PF08392.12 EXF76690.1 - 2.6e-05 23.7 0.3 5.1e-05 22.7 0.0 1.6 2 0 0 2 2 2 1 FAE1/Type III polyketide synthase-like protein ACP_syn_III PF08545.10 EXF76690.1 - 0.0036 17.1 0.7 0.0082 16.0 0.2 1.9 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III ACP_syn_III_C PF08541.10 EXF76690.1 - 0.0036 17.4 0.0 0.018 15.2 0.0 2.2 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal TRAUB PF08164.12 EXF76692.1 - 1.6e-29 102.3 0.1 1.6e-29 102.3 0.1 3.2 3 0 0 3 3 3 1 Apoptosis-antagonizing transcription factor, C-terminal AATF-Che1 PF13339.6 EXF76692.1 - 1.1e-28 100.6 2.5 1.1e-28 100.6 2.5 2.6 2 0 0 2 2 2 1 Apoptosis antagonizing transcription factor Fungal_trans PF04082.18 EXF76693.1 - 2.3e-12 46.5 0.0 5.4e-12 45.3 0.0 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain HalX PF08663.10 EXF76693.1 - 0.008 16.5 0.2 0.019 15.3 0.2 1.6 1 0 0 1 1 1 1 HalX domain P63C PF10546.9 EXF76693.1 - 0.046 14.3 1.3 0.23 12.1 0.2 2.5 1 1 1 2 2 2 0 P63C domain DASH_Dad3 PF08656.10 EXF76693.1 - 3 8.0 4.5 8 6.6 0.5 2.5 2 1 0 2 2 2 0 DASH complex subunit Dad3 Esterase_phd PF10503.9 EXF76694.1 - 5.8e-21 75.0 0.5 7.4e-21 74.7 0.5 1.1 1 0 0 1 1 1 1 Esterase PHB depolymerase Peptidase_S9 PF00326.21 EXF76694.1 - 1.7e-07 30.9 0.1 3.6e-07 29.9 0.1 1.5 1 1 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_2 PF02230.16 EXF76694.1 - 0.00047 20.0 0.0 0.036 13.9 0.0 2.4 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase COesterase PF00135.28 EXF76694.1 - 0.0045 15.9 0.0 0.007 15.3 0.0 1.2 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EXF76694.1 - 0.029 14.2 0.0 0.04 13.8 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Esterase PF00756.20 EXF76694.1 - 0.082 12.5 0.1 0.12 12.0 0.1 1.3 1 0 0 1 1 1 0 Putative esterase Pyr_redox_2 PF07992.14 EXF76697.1 - 7.6e-37 127.1 0.1 1.1e-36 126.6 0.1 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EXF76697.1 - 3e-11 43.7 1.3 4.2e-10 40.1 0.1 2.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EXF76697.1 - 3.9e-06 26.4 0.0 7e-06 25.5 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EXF76697.1 - 0.00016 20.9 0.0 0.00031 20.0 0.0 1.4 1 0 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) Lycopene_cycl PF05834.12 EXF76697.1 - 0.00071 18.7 0.1 0.0068 15.5 0.1 2.5 3 0 0 3 3 3 1 Lycopene cyclase protein HI0933_like PF03486.14 EXF76697.1 - 0.0027 16.5 5.4 0.15 10.7 0.0 3.4 3 1 1 4 4 4 2 HI0933-like protein Trp_halogenase PF04820.14 EXF76697.1 - 0.0041 16.0 0.2 4.3 6.1 0.0 3.0 2 1 0 3 3 3 1 Tryptophan halogenase DAO PF01266.24 EXF76697.1 - 0.013 15.1 0.9 1.3 8.5 0.0 3.0 3 1 1 4 4 4 0 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EXF76697.1 - 0.035 14.1 0.5 12 5.9 0.0 3.8 3 1 1 4 4 4 0 FAD-NAD(P)-binding Thi4 PF01946.17 EXF76697.1 - 0.076 12.3 0.1 11 5.2 0.0 2.4 2 0 0 2 2 2 0 Thi4 family PNPase_C PF12111.8 EXF76697.1 - 0.16 11.4 0.1 0.38 10.2 0.1 1.7 1 0 0 1 1 1 0 Polyribonucleotide phosphorylase C terminal GIDA PF01134.22 EXF76697.1 - 0.36 9.8 5.8 1.7 7.6 0.0 3.3 4 0 0 4 4 4 0 Glucose inhibited division protein A Acetyltransf_1 PF00583.25 EXF76698.1 - 3.3e-06 27.3 0.2 5.8e-06 26.5 0.2 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EXF76698.1 - 0.00033 21.0 0.0 0.00079 19.8 0.0 1.8 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EXF76698.1 - 0.0005 20.0 0.0 0.0013 18.6 0.0 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain NB-ARC PF00931.22 EXF76699.1 - 3.1e-12 46.2 0.0 6.5e-12 45.2 0.0 1.6 1 0 0 1 1 1 1 NB-ARC domain TPR_12 PF13424.6 EXF76699.1 - 1.6e-09 37.9 8.7 1.5e-05 25.2 0.3 4.3 3 1 1 4 4 4 2 Tetratricopeptide repeat AAA_16 PF13191.6 EXF76699.1 - 4.9e-07 30.3 1.8 0.00012 22.6 0.0 3.8 3 1 0 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 EXF76699.1 - 1.2e-05 25.6 0.0 5.7e-05 23.4 0.0 2.1 1 0 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 EXF76699.1 - 0.0017 18.3 0.5 0.0082 16.1 0.0 2.2 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea NACHT PF05729.12 EXF76699.1 - 0.0048 16.8 0.0 0.012 15.5 0.0 1.7 1 0 0 1 1 1 1 NACHT domain TPR_2 PF07719.17 EXF76699.1 - 0.021 14.9 0.6 0.021 14.9 0.6 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat ComR_TPR PF18710.1 EXF76699.1 - 0.022 14.3 0.5 0.022 14.3 0.5 2.1 2 0 0 2 2 2 0 ComR tetratricopeptide TPR_1 PF00515.28 EXF76699.1 - 1.3 8.9 4.8 1.6 8.7 0.4 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.6 EXF76699.1 - 3.9 7.5 5.5 45 4.1 0.1 4.6 5 0 0 5 5 5 0 Tetratricopeptide repeat Syntaxin-6_N PF09177.11 EXF76700.1 - 0.025 15.1 0.3 0.1 13.2 0.3 2.1 1 0 0 1 1 1 0 Syntaxin 6, N-terminal MFS_1 PF07690.16 EXF76702.1 - 1.1e-16 60.7 23.7 1.1e-16 60.7 23.7 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily V_ATPase_I PF01496.19 EXF76702.1 - 0.031 12.2 0.0 0.046 11.7 0.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TauD PF02668.16 EXF76703.1 - 5.1e-62 210.1 0.7 6.7e-62 209.7 0.7 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF3328 PF11807.8 EXF76704.1 - 8.1e-27 94.4 0.4 9.7e-27 94.2 0.4 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) DUF2106 PF09879.9 EXF76704.1 - 0.18 11.3 0.0 0.25 10.9 0.0 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2106) Mannosyl_trans3 PF11051.8 EXF76706.1 - 0.005 16.2 0.0 0.0085 15.5 0.0 1.3 1 0 0 1 1 1 1 Mannosyltransferase putative Resistin PF06954.11 EXF76707.1 - 0.44 11.1 4.4 0.64 10.6 3.2 1.9 1 1 1 2 2 2 0 Resistin Kelch_5 PF13854.6 EXF76708.1 - 3.7e-19 68.3 0.4 0.0059 16.6 0.0 5.4 5 0 0 5 5 5 5 Kelch motif Kelch_4 PF13418.6 EXF76708.1 - 1.1e-16 60.6 2.9 2e-07 30.9 0.0 5.0 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_3 PF13415.6 EXF76708.1 - 1.4e-13 50.7 7.6 1.8e-06 28.1 0.1 5.5 6 1 0 6 6 6 2 Galactose oxidase, central domain Kelch_6 PF13964.6 EXF76708.1 - 1.4e-10 41.1 0.9 0.14 12.5 0.0 4.2 3 1 1 4 4 4 3 Kelch motif Kelch_2 PF07646.15 EXF76708.1 - 7.3e-06 25.8 1.8 0.014 15.4 0.0 4.3 4 1 1 5 5 5 2 Kelch motif Kelch_1 PF01344.25 EXF76708.1 - 0.00011 21.7 1.0 13 5.5 0.0 4.6 4 0 0 4 4 4 2 Kelch motif HgmA PF04209.13 EXF76709.1 - 8.5e-190 630.9 0.1 9.9e-190 630.7 0.1 1.0 1 0 0 1 1 1 1 homogentisate 1,2-dioxygenase DUF3663 PF12404.8 EXF76710.1 - 0.058 13.4 0.0 0.17 12.0 0.0 1.8 1 1 0 1 1 1 0 Peptidase PIF6 PF05341.11 EXF76710.1 - 0.1 12.7 0.1 7.9 6.7 0.0 2.1 2 0 0 2 2 2 0 Per os infectivity factor 6 CN_hydrolase PF00795.22 EXF76711.1 - 2.7e-30 105.6 0.0 3.6e-30 105.2 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase NAD_synthase PF02540.17 EXF76711.1 - 2.5e-22 79.2 0.0 7.8e-22 77.6 0.0 1.8 1 1 0 1 1 1 1 NAD synthase Asn_synthase PF00733.21 EXF76711.1 - 0.0036 17.0 0.1 0.0067 16.1 0.1 1.3 1 0 0 1 1 1 1 Asparagine synthase ketoacyl-synt PF00109.26 EXF76712.1 - 3.9e-82 275.6 0.0 6.6e-82 274.9 0.0 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain SAT PF16073.5 EXF76712.1 - 1.4e-71 241.0 0.5 1.4e-71 241.0 0.5 2.4 3 0 0 3 3 3 1 Starter unit:ACP transacylase in aflatoxin biosynthesis Acyl_transf_1 PF00698.21 EXF76712.1 - 6.3e-43 147.5 0.0 1.5e-42 146.3 0.0 1.6 2 0 0 2 2 2 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EXF76712.1 - 1.2e-33 115.6 0.4 2.5e-33 114.6 0.4 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Thioesterase PF00975.20 EXF76712.1 - 4.3e-21 76.1 0.7 1.3e-20 74.5 0.0 2.2 3 0 0 3 3 3 1 Thioesterase domain PP-binding PF00550.25 EXF76712.1 - 4.8e-13 49.3 0.9 1.3e-12 47.9 0.9 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site PS-DH PF14765.6 EXF76712.1 - 2.9e-08 33.3 0.0 4.7e-08 32.6 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase Thiolase_N PF00108.23 EXF76712.1 - 3e-05 23.5 0.0 8.1e-05 22.1 0.0 1.7 1 0 0 1 1 1 1 Thiolase, N-terminal domain KAsynt_C_assoc PF16197.5 EXF76712.1 - 5e-05 23.7 0.1 0.00018 21.9 0.0 1.9 2 0 0 2 2 2 1 Ketoacyl-synthetase C-terminal extension Abhydrolase_6 PF12697.7 EXF76712.1 - 5.6e-05 23.9 2.1 5.6e-05 23.9 2.1 4.0 5 0 0 5 5 5 1 Alpha/beta hydrolase family EthD PF07110.11 EXF76713.1 - 9.7e-23 81.1 0.5 1.2e-22 80.8 0.5 1.1 1 0 0 1 1 1 1 EthD domain MmlI PF09448.10 EXF76713.1 - 0.0003 21.2 0.1 0.00039 20.8 0.1 1.2 1 0 0 1 1 1 1 Methylmuconolactone methyl-isomerase Speriolin_C PF15059.6 EXF76713.1 - 0.038 14.1 0.1 0.067 13.3 0.1 1.4 1 1 0 1 1 1 0 Speriolin C-terminus RE_MamI PF09567.10 EXF76713.1 - 0.15 11.7 0.0 0.17 11.5 0.0 1.2 1 0 0 1 1 1 0 MamI restriction endonuclease Methyltransf_2 PF00891.18 EXF76714.1 - 1.7e-18 66.7 0.0 4.1e-17 62.2 0.0 2.1 2 0 0 2 2 2 1 O-methyltransferase domain Cas9_a PF18470.1 EXF76714.1 - 0.091 12.3 0.0 0.15 11.6 0.0 1.3 1 0 0 1 1 1 0 Cas9 alpha-helical lobe domain FMO-like PF00743.19 EXF76715.1 - 1.2e-14 53.7 0.0 1.4e-14 53.4 0.0 1.0 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.6 EXF76715.1 - 0.0016 18.7 0.1 0.0018 18.4 0.1 1.2 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain ThiF PF00899.21 EXF76715.1 - 0.0082 15.5 0.1 0.0094 15.3 0.1 1.1 1 0 0 1 1 1 1 ThiF family UDPG_MGDP_dh_N PF03721.14 EXF76715.1 - 0.013 15.1 0.0 0.035 13.7 0.0 1.6 1 1 1 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain IlvN PF07991.12 EXF76715.1 - 0.015 14.9 0.0 0.015 14.9 0.0 1.1 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain NAD_binding_2 PF03446.15 EXF76715.1 - 0.043 14.0 0.0 0.044 13.9 0.0 1.2 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Glu_dehyd_C PF16912.5 EXF76715.1 - 0.071 12.6 0.1 0.082 12.4 0.1 1.1 1 0 0 1 1 1 0 Glucose dehydrogenase C-terminus Cu-oxidase_2 PF07731.14 EXF76716.1 - 6.1e-25 87.5 7.6 8.4e-22 77.4 1.1 3.5 3 0 0 3 3 3 3 Multicopper oxidase Cu-oxidase PF00394.22 EXF76716.1 - 6.9e-20 71.8 0.0 1.4e-19 70.8 0.0 1.5 1 0 0 1 1 1 1 Multicopper oxidase Cu-oxidase_3 PF07732.15 EXF76716.1 - 2.8e-15 56.4 0.6 1.5e-14 54.1 0.1 2.2 2 0 0 2 2 2 1 Multicopper oxidase Fasciclin PF02469.22 EXF76717.1 - 4.7e-21 75.3 0.0 7.1e-12 45.7 0.0 2.8 2 1 0 2 2 2 2 Fasciclin domain Pam17 PF08566.10 EXF76718.1 - 1.4e-66 223.4 0.0 2e-66 222.9 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial import protein Pam17 Med3 PF11593.8 EXF76718.1 - 0.0027 17.0 4.6 0.003 16.8 4.6 1.1 1 0 0 1 1 1 1 Mediator complex subunit 3 fungal GCHY-1 PF02649.14 EXF76718.1 - 0.14 11.6 0.5 0.2 11.1 0.5 1.1 1 0 0 1 1 1 0 Type I GTP cyclohydrolase folE2 Rib_recp_KP_reg PF05104.12 EXF76718.1 - 0.92 10.5 4.7 2 9.5 4.7 1.6 1 0 0 1 1 1 0 Ribosome receptor lysine/proline rich region ThiF PF00899.21 EXF76719.1 - 1.7e-55 188.1 0.0 6.7e-55 186.1 0.0 1.8 1 1 1 2 2 2 1 ThiF family Rhodanese PF00581.20 EXF76719.1 - 8.8e-12 45.5 0.0 6.2e-11 42.8 0.0 2.1 2 0 0 2 2 2 1 Rhodanese-like domain NAD_binding_7 PF13241.6 EXF76719.1 - 0.009 16.4 0.0 0.024 15.1 0.0 1.7 2 0 0 2 2 2 1 Putative NAD(P)-binding Shikimate_DH PF01488.20 EXF76719.1 - 0.0095 16.0 0.4 0.037 14.1 0.0 2.2 2 1 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase UDPG_MGDP_dh_N PF03721.14 EXF76719.1 - 0.18 11.4 1.4 0.31 10.6 1.4 1.5 1 1 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain SLX9 PF15341.6 EXF76720.1 - 4.2e-40 137.2 5.0 5.8e-40 136.7 5.0 1.2 1 0 0 1 1 1 1 Ribosome biogenesis protein SLX9 DTW PF03942.15 EXF76720.1 - 0.032 13.9 0.0 0.05 13.3 0.0 1.3 1 0 0 1 1 1 0 DTW domain Hrs_helical PF12210.8 EXF76720.1 - 0.12 12.9 0.2 0.2 12.2 0.2 1.4 1 0 0 1 1 1 0 Hepatocyte growth factor-regulated tyrosine kinase substrate HCO3_cotransp PF00955.21 EXF76721.1 - 1.6e-80 271.4 13.4 1.1e-40 140.0 0.2 2.2 1 1 1 2 2 2 2 HCO3- transporter family TNFR_16_TM PF18422.1 EXF76721.1 - 7.9 6.5 17.6 0.35 10.8 5.3 3.7 3 0 0 3 3 3 0 Tumor necrosis factor receptor member 16 trans-membrane domain Pkinase PF00069.25 EXF76723.1 - 3.5e-72 243.0 0.0 4.8e-72 242.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF76723.1 - 9.1e-46 156.2 0.0 1.4e-45 155.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 EXF76723.1 - 1.1e-17 64.1 0.0 3.5e-17 62.5 0.0 2.0 1 0 0 1 1 1 1 P21-Rho-binding domain Kinase-like PF14531.6 EXF76723.1 - 1.4e-07 31.2 0.0 3.3e-07 29.9 0.0 1.6 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EXF76723.1 - 9.5e-07 27.9 0.0 2.1e-06 26.8 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 EXF76723.1 - 0.0045 16.0 0.0 0.0099 14.9 0.0 1.5 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EXF76723.1 - 0.026 13.9 0.1 0.2 11.0 0.0 2.1 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EXF76723.1 - 0.27 11.1 0.0 0.27 11.1 0.0 2.7 3 1 0 3 3 3 0 Phosphotransferase enzyme family KH_1 PF00013.29 EXF76724.1 - 3.2e-91 299.1 30.0 2.7e-14 52.7 0.1 13.6 14 1 0 14 14 14 9 KH domain SLS PF14611.6 EXF76724.1 - 7.4e-11 42.3 5.6 0.46 10.3 0.0 7.3 4 2 4 8 8 8 4 Mitochondrial inner-membrane-bound regulator KH_2 PF07650.17 EXF76724.1 - 4.2e-10 39.3 25.7 0.023 14.5 0.2 7.3 6 1 1 7 7 7 4 KH domain KH_4 PF13083.6 EXF76724.1 - 0.051 13.4 12.3 0.33 10.9 0.2 6.0 7 0 0 7 7 7 0 KH domain DUF4974 PF16344.5 EXF76724.1 - 0.094 12.7 0.0 45 4.2 0.0 3.8 5 0 0 5 5 5 0 Domain of unknown function (DUF4974) CTD PF12815.7 EXF76724.1 - 0.16 12.5 2.4 0.43 11.2 2.4 1.6 1 0 0 1 1 1 0 Spt5 C-terminal nonapeptide repeat binding Spt4 DUF2067 PF09840.9 EXF76724.1 - 0.41 10.2 6.0 20 4.7 0.2 4.6 5 0 0 5 5 5 0 Uncharacterized protein conserved in archaea (DUF2067) BON PF04972.17 EXF76724.1 - 2.6 8.4 7.5 17 5.8 0.0 4.4 4 0 0 4 4 4 0 BON domain YqgF PF14639.6 EXF76724.1 - 3.3 7.5 9.5 7.5 6.3 0.6 4.2 2 1 2 4 4 4 0 Holliday-junction resolvase-like of SPT6 AMP-binding PF00501.28 EXF76725.1 - 6.8e-85 285.2 0.0 9.5e-85 284.7 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EXF76725.1 - 0.00043 21.2 0.1 0.0015 19.5 0.1 2.0 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain CPL PF08144.11 EXF76725.1 - 0.15 12.4 0.0 0.31 11.4 0.0 1.4 1 0 0 1 1 1 0 CPL (NUC119) domain DUF3671 PF12420.8 EXF76726.1 - 0.93 9.6 5.2 12 6.0 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function PhoLip_ATPase_C PF16212.5 EXF76726.1 - 3 7.5 10.0 30 4.3 10.0 2.0 1 1 0 1 1 1 0 Phospholipid-translocating P-type ATPase C-terminal UCH PF00443.29 EXF76727.1 - 2.1e-33 115.9 0.0 2.9e-33 115.5 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EXF76727.1 - 2.2e-18 66.9 0.0 4.2e-18 66.0 0.0 1.4 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Rhodanese PF00581.20 EXF76727.1 - 1.1e-05 25.9 0.0 2.4e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 Rhodanese-like domain zf_UBZ PF18439.1 EXF76727.1 - 0.73 9.5 2.7 13 5.5 0.2 2.4 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger VHS PF00790.19 EXF76728.1 - 4.3e-40 136.8 2.1 1.3e-39 135.2 0.1 2.2 2 0 0 2 2 2 1 VHS domain FYVE PF01363.21 EXF76728.1 - 9e-15 54.6 4.2 1.5e-14 53.9 4.2 1.3 1 0 0 1 1 1 1 FYVE zinc finger UIM PF02809.20 EXF76728.1 - 2.7e-05 23.8 16.5 0.0024 17.6 1.5 2.9 3 0 0 3 3 3 2 Ubiquitin interaction motif GAT PF03127.14 EXF76728.1 - 7.8e-05 22.9 0.1 0.00026 21.2 0.0 2.0 2 0 0 2 2 2 1 GAT domain FYVE_2 PF02318.16 EXF76728.1 - 0.034 14.4 0.2 0.067 13.4 0.2 1.5 1 0 0 1 1 1 0 FYVE-type zinc finger Fer4_2 PF12797.7 EXF76728.1 - 1.2 9.4 8.0 2.3 8.5 0.2 2.5 2 0 0 2 2 2 0 4Fe-4S binding domain His_Phos_1 PF00300.22 EXF76729.1 - 1.5e-14 54.1 4.4 3.1e-14 53.1 0.6 2.6 1 1 1 2 2 2 1 Histidine phosphatase superfamily (branch 1) HTH_OrfB_IS605 PF12323.8 EXF76729.1 - 1.3 8.6 4.0 0.51 9.9 0.7 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain Cpn60_TCP1 PF00118.24 EXF76730.1 - 3.8e-158 527.1 5.5 4.3e-158 527.0 5.5 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Enolase_N PF03952.16 EXF76730.1 - 0.013 15.7 3.4 8.4 6.6 0.1 3.3 3 0 0 3 3 3 0 Enolase, N-terminal domain GTP_EFTU PF00009.27 EXF76731.1 - 9.6e-47 159.0 0.1 5.7e-46 156.5 0.0 2.1 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain HBS1_N PF08938.10 EXF76731.1 - 5.1e-24 84.4 1.8 5.1e-24 84.4 1.8 2.0 2 0 0 2 2 2 1 HBS1 N-terminus MMR_HSR1 PF01926.23 EXF76731.1 - 1.5e-09 38.0 0.0 2e-05 24.7 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase GTP_EFTU_D3 PF03143.17 EXF76731.1 - 4e-08 33.5 0.0 1.3e-07 31.9 0.0 1.9 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EXF76731.1 - 4.2e-07 30.3 0.2 1.3e-06 28.7 0.2 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 Roc PF08477.13 EXF76731.1 - 0.00012 22.3 0.0 0.017 15.3 0.0 2.9 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Septin PF00735.18 EXF76731.1 - 0.0065 15.8 0.0 0.013 14.8 0.0 1.4 1 0 0 1 1 1 1 Septin Ras PF00071.22 EXF76731.1 - 0.0098 15.5 0.1 0.23 11.0 0.0 2.7 2 0 0 2 2 2 1 Ras family SRPRB PF09439.10 EXF76731.1 - 0.044 13.2 0.0 2.7 7.4 0.0 2.7 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit GTP_EFTU_D4 PF14578.6 EXF76731.1 - 0.13 12.1 0.4 0.32 10.9 0.4 1.7 1 0 0 1 1 1 0 Elongation factor Tu domain 4 FeoB_N PF02421.18 EXF76731.1 - 0.15 11.6 0.1 2.9 7.4 0.0 2.6 2 1 0 2 2 2 0 Ferrous iron transport protein B HSP70 PF00012.20 EXF76732.1 - 6.7e-264 876.6 15.9 7.6e-264 876.4 15.9 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EXF76732.1 - 3.6e-18 65.5 2.7 1e-16 60.7 0.8 2.2 2 0 0 2 2 2 2 MreB/Mbl protein FtsA PF14450.6 EXF76732.1 - 2.3e-05 24.8 2.7 0.083 13.3 0.0 3.6 3 1 0 3 3 3 2 Cell division protein FtsA Hydantoinase_A PF01968.18 EXF76732.1 - 0.0035 16.6 2.3 0.084 12.1 0.1 2.9 3 0 0 3 3 3 1 Hydantoinase/oxoprolinase DDR PF08841.10 EXF76732.1 - 0.0066 15.5 0.3 0.15 11.0 0.1 2.2 2 0 0 2 2 2 1 Diol dehydratase reactivase ATPase-like domain p450 PF00067.22 EXF76734.1 - 1.4e-62 212.0 0.0 1.7e-62 211.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 FAD_binding_3 PF01494.19 EXF76735.1 - 9.5e-16 58.0 4.2 6.5e-15 55.2 3.6 2.2 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 EXF76735.1 - 1.8e-07 31.3 0.2 6.6e-07 29.5 0.1 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EXF76735.1 - 3.7e-05 23.1 0.5 8.4e-05 21.9 0.4 1.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EXF76735.1 - 7.1e-05 22.5 2.1 0.00016 21.4 1.5 1.9 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EXF76735.1 - 7.7e-05 21.9 2.4 0.0002 20.6 1.9 1.9 2 0 0 2 2 2 1 FAD binding domain HI0933_like PF03486.14 EXF76735.1 - 0.00017 20.4 0.2 0.0003 19.6 0.2 1.4 1 1 0 1 1 1 1 HI0933-like protein Thi4 PF01946.17 EXF76735.1 - 0.002 17.4 0.1 0.0035 16.6 0.1 1.3 1 0 0 1 1 1 1 Thi4 family AlaDh_PNT_C PF01262.21 EXF76735.1 - 0.0021 17.4 0.1 0.0035 16.7 0.1 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.22 EXF76735.1 - 0.015 14.4 0.4 0.024 13.7 0.4 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A Lycopene_cycl PF05834.12 EXF76735.1 - 0.036 13.1 2.6 0.68 8.9 0.3 2.4 3 0 0 3 3 3 0 Lycopene cyclase protein Pyr_redox PF00070.27 EXF76735.1 - 0.061 13.9 0.1 0.21 12.2 0.1 1.9 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EXF76735.1 - 0.074 13.0 0.5 0.38 10.7 0.2 2.4 2 1 0 2 2 2 0 FAD-NAD(P)-binding 3HCDH_N PF02737.18 EXF76735.1 - 0.13 12.1 1.3 0.24 11.3 0.2 1.9 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pyr_redox_3 PF13738.6 EXF76735.1 - 0.19 10.9 5.5 0.13 11.5 0.8 2.3 2 1 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase RdRP PF05183.12 EXF76736.1 - 3.3e-132 442.1 0.0 4.5e-132 441.7 0.0 1.1 1 0 0 1 1 1 1 RNA dependent RNA polymerase PP2C PF00481.21 EXF76738.1 - 9.2e-32 110.7 0.0 2e-31 109.5 0.0 1.5 1 1 0 1 1 1 1 Protein phosphatase 2C Git3 PF11710.8 EXF76739.1 - 8.8e-09 35.4 1.3 1.2e-08 34.9 1.3 1.2 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 Dicty_CAR PF05462.11 EXF76739.1 - 2.5e-05 23.6 4.1 0.00026 20.2 1.7 2.1 2 0 0 2 2 2 2 Slime mold cyclic AMP receptor GPR_Gpa2_C PF11970.8 EXF76739.1 - 0.048 13.7 0.0 0.086 12.9 0.0 1.4 1 0 0 1 1 1 0 G protein-coupled glucose receptor regulating Gpa2 C-term PALP PF00291.25 EXF76740.1 - 2.5e-60 204.4 0.9 2.9e-60 204.2 0.9 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme BATS PF06968.13 EXF76741.1 - 3.1e-24 84.9 1.0 8.3e-24 83.6 0.1 2.2 2 1 0 2 2 2 1 Biotin and Thiamin Synthesis associated domain Radical_SAM PF04055.21 EXF76741.1 - 7.1e-15 55.8 0.1 1.3e-14 54.9 0.1 1.5 1 0 0 1 1 1 1 Radical SAM superfamily MFS_1 PF07690.16 EXF76742.1 - 1e-43 149.7 37.8 1e-43 149.7 37.8 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF76742.1 - 1.1e-10 40.9 9.2 1.1e-10 40.9 9.2 2.8 1 1 0 2 2 2 1 Sugar (and other) transporter MFS_3 PF05977.13 EXF76742.1 - 0.013 13.9 3.3 0.024 13.0 3.3 1.4 1 0 0 1 1 1 0 Transmembrane secretion effector DUF2583 PF10762.9 EXF76742.1 - 1.4 9.4 4.9 0.61 10.5 1.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2583) TrkH PF02386.16 EXF76743.1 - 9.4e-100 334.4 6.8 1.1e-97 327.6 0.8 2.1 2 0 0 2 2 2 2 Cation transport protein Questin_oxidase PF14027.6 EXF76743.1 - 1.4e-73 248.4 0.0 2e-73 247.9 0.0 1.2 1 0 0 1 1 1 1 Questin oxidase-like Na_H_Exchanger PF00999.21 EXF76744.1 - 2.6e-45 154.8 13.4 5.2e-45 153.9 13.3 1.4 1 1 0 1 1 1 1 Sodium/hydrogen exchanger family CoA_transf_3 PF02515.17 EXF76745.1 - 1.2e-34 120.0 0.0 4.6e-33 114.8 0.0 2.1 2 0 0 2 2 2 2 CoA-transferase family III Catalase PF00199.19 EXF76747.1 - 6.7e-175 581.7 0.1 1e-174 581.2 0.1 1.2 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.12 EXF76747.1 - 1.7e-12 47.3 0.0 3.6e-12 46.3 0.0 1.6 1 0 0 1 1 1 1 Catalase-related immune-responsive MFS_1 PF07690.16 EXF76748.1 - 7.2e-18 64.6 31.6 7.6e-14 51.4 20.1 2.5 2 1 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF76748.1 - 1.6 7.5 28.8 0.03 13.2 3.9 3.9 3 1 1 4 4 4 0 Sugar (and other) transporter SEN1_N PF12726.7 EXF76749.1 - 3.1e-204 680.4 5.5 4.8e-204 679.8 5.5 1.3 1 0 0 1 1 1 1 SEN1 N terminal AAA_11 PF13086.6 EXF76749.1 - 1.6e-71 241.1 0.8 1.6e-71 241.1 0.8 2.8 3 0 0 3 3 3 1 AAA domain AAA_12 PF13087.6 EXF76749.1 - 1.3e-61 207.7 0.0 2.5e-61 206.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EXF76749.1 - 1.7e-10 41.4 0.0 8.4e-10 39.2 0.0 2.2 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EXF76749.1 - 4.7e-09 36.2 0.3 3.1e-05 23.8 0.1 2.6 2 0 0 2 2 2 2 AAA domain UvrD-helicase PF00580.21 EXF76749.1 - 1.5e-06 27.9 3.5 0.00012 21.8 0.0 3.6 2 1 1 3 3 3 1 UvrD/REP helicase N-terminal domain Viral_helicase1 PF01443.18 EXF76749.1 - 8e-06 25.8 0.1 0.082 12.6 0.0 3.5 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase AAA_22 PF13401.6 EXF76749.1 - 0.097 12.9 0.0 0.58 10.4 0.0 2.4 1 0 0 1 1 1 0 AAA domain VWA_2 PF13519.6 EXF76749.1 - 0.21 12.3 1.0 1.2 9.8 0.4 2.5 2 0 0 2 2 2 0 von Willebrand factor type A domain HhH-GPD PF00730.25 EXF76750.1 - 5.7e-06 26.7 0.0 1.3e-05 25.6 0.0 1.6 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein DNA_methylase PF00145.17 EXF76751.1 - 3.5e-41 141.7 0.0 4e-30 105.3 0.0 2.2 1 1 1 2 2 2 2 C-5 cytosine-specific DNA methylase Cons_hypoth95 PF03602.15 EXF76751.1 - 0.16 11.6 0.0 0.29 10.8 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Pectinesterase PF01095.19 EXF76752.1 - 1.6e-26 92.7 0.1 2.4e-22 79.0 0.1 2.2 2 0 0 2 2 2 2 Pectinesterase Glyco_hydro_28 PF00295.17 EXF76753.1 - 1.3e-52 178.9 13.6 1.9e-52 178.3 13.6 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 Acetyltransf_3 PF13302.7 EXF76754.1 - 2.9e-14 53.9 0.0 2.8e-13 50.7 0.0 2.1 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 EXF76754.1 - 0.0016 18.1 0.5 1.1 8.9 0.1 2.2 1 1 1 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EXF76754.1 - 0.12 12.6 0.0 1.3 9.3 0.0 2.1 2 0 0 2 2 2 0 Acetyltransferase (GNAT) family zf_C2H2_13 PF18508.1 EXF76754.1 - 0.13 11.8 0.0 0.3 10.7 0.0 1.5 2 0 0 2 2 2 0 Zinc finger domain POP1 PF06978.11 EXF76755.1 - 2.9e-74 249.5 16.9 2.9e-74 249.5 16.9 2.2 2 0 0 2 2 2 1 Ribonucleases P/MRP protein subunit POP1 POPLD PF08170.12 EXF76755.1 - 5.4e-29 100.4 0.1 5.4e-29 100.4 0.1 3.0 3 0 0 3 3 3 1 POPLD (NUC188) domain GCV_T_C PF08669.11 EXF76755.1 - 0.13 12.2 0.0 0.38 10.7 0.0 1.8 1 0 0 1 1 1 0 Glycine cleavage T-protein C-terminal barrel domain EAF PF09816.9 EXF76756.1 - 4.9e-23 81.4 0.0 1e-22 80.4 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase II transcription elongation factor MmgE_PrpD PF03972.14 EXF76757.1 - 1.8e-148 494.7 0.0 2.1e-148 494.5 0.0 1.1 1 0 0 1 1 1 1 MmgE/PrpD family SH3_1 PF00018.28 EXF76758.1 - 7.5e-13 47.9 0.0 1.3e-12 47.1 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EXF76758.1 - 5.8e-08 32.5 0.0 8.7e-08 31.9 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EXF76758.1 - 2e-05 24.2 0.0 3.2e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain DUF910 PF06014.11 EXF76758.1 - 0.21 11.6 0.0 0.42 10.6 0.0 1.4 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF910) DUF4360 PF14273.6 EXF76759.1 - 6.9e-27 94.5 0.2 8.7e-27 94.1 0.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4360) DUF3405 PF11885.8 EXF76760.1 - 4.9e-191 635.8 0.5 4.9e-191 635.8 0.5 2.4 2 0 0 2 2 1 1 Protein of unknown function (DUF3405) HAUS6_N PF14661.6 EXF76760.1 - 0.046 13.3 7.1 0.073 12.6 7.1 1.3 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus UPF0242 PF06785.11 EXF76760.1 - 0.066 13.3 15.6 0.11 12.6 15.6 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus V_ATPase_I PF01496.19 EXF76760.1 - 0.13 10.2 13.5 0.18 9.7 13.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family RR_TM4-6 PF06459.12 EXF76760.1 - 0.19 11.5 19.1 0.35 10.7 19.1 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DDHD PF02862.17 EXF76760.1 - 0.19 11.8 6.1 0.33 11.1 6.1 1.3 1 0 0 1 1 1 0 DDHD domain PA26 PF04636.13 EXF76760.1 - 0.31 9.9 6.9 0.5 9.2 6.9 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Asp-B-Hydro_N PF05279.11 EXF76760.1 - 0.37 10.8 20.7 0.59 10.2 20.7 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region DUF3450 PF11932.8 EXF76760.1 - 0.49 9.7 14.1 1 8.6 14.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Neur_chan_memb PF02932.16 EXF76760.1 - 0.58 10.2 2.7 0.96 9.5 2.7 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Fmp27_WPPW PF10359.9 EXF76760.1 - 0.65 8.8 18.4 1.1 8.0 14.3 2.2 2 0 0 2 2 2 0 RNA pol II promoter Fmp27 protein domain APG6_N PF17675.1 EXF76760.1 - 0.84 10.2 39.0 1.5 9.3 39.0 1.4 1 0 0 1 1 1 0 Apg6 coiled-coil region Membralin PF09746.9 EXF76760.1 - 1.4 7.9 3.0 2 7.3 3.0 1.2 1 0 0 1 1 1 0 Tumour-associated protein HAUS-augmin3 PF14932.6 EXF76760.1 - 3.6 7.1 26.1 6.4 6.3 26.1 1.3 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 Exonuc_VII_L PF02601.15 EXF76760.1 - 3.6 7.1 13.7 4.5 6.8 11.8 1.9 2 0 0 2 2 2 0 Exonuclease VII, large subunit YabA PF06156.13 EXF76760.1 - 3.7 8.3 17.3 8.1 7.1 17.3 1.5 1 0 0 1 1 1 0 Initiation control protein YabA Rgp1 PF08737.10 EXF76760.1 - 4.3 6.4 9.2 6.5 5.8 9.2 1.2 1 0 0 1 1 1 0 Rgp1 DUF966 PF06136.13 EXF76760.1 - 4.7 6.8 15.5 7.2 6.2 15.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Vfa1 PF08432.10 EXF76760.1 - 5.5 7.3 23.4 9.2 6.6 23.4 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Macoilin PF09726.9 EXF76760.1 - 6.6 5.2 18.5 9.5 4.6 18.5 1.1 1 0 0 1 1 1 0 Macoilin family PIEZO PF15917.5 EXF76760.1 - 9.6 5.6 14.5 19 4.6 14.5 1.4 1 0 0 1 1 1 0 Piezo Med17 PF10156.9 EXF76761.1 - 0.053 12.2 0.0 0.053 12.2 0.0 1.0 1 0 0 1 1 1 0 Subunit 17 of Mediator complex HALZ PF02183.18 EXF76762.1 - 0.14 12.4 7.6 0.38 11.0 0.9 2.5 1 1 1 2 2 2 0 Homeobox associated leucine zipper YabA PF06156.13 EXF76762.1 - 0.32 11.7 8.9 1.3 9.7 8.9 2.1 1 1 0 1 1 1 0 Initiation control protein YabA HalX PF08663.10 EXF76762.1 - 5.1 7.5 8.4 0.16 12.3 1.1 2.3 2 1 0 2 2 2 0 HalX domain COesterase PF00135.28 EXF76765.1 - 3.4e-90 303.4 0.0 4.2e-90 303.1 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EXF76765.1 - 0.00072 19.5 0.5 0.011 15.6 0.0 2.1 2 0 0 2 2 2 1 alpha/beta hydrolase fold Aspzincin_M35 PF14521.6 EXF76767.1 - 1e-27 97.4 1.9 1.6e-27 96.9 1.9 1.3 1 0 0 1 1 1 1 Lysine-specific metallo-endopeptidase HRXXH PF13933.6 EXF76767.1 - 0.0014 18.2 1.5 0.6 9.6 0.2 2.3 2 1 0 2 2 2 2 Putative peptidase family DUF723 PF05265.13 EXF76769.1 - 0.12 12.3 0.0 0.26 11.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF723) Peptidase_C1_2 PF03051.15 EXF76770.1 - 4.9e-150 500.1 0.0 5.7e-150 499.9 0.0 1.0 1 0 0 1 1 1 1 Peptidase C1-like family Peptidase_C1 PF00112.23 EXF76770.1 - 2.4e-07 31.1 0.1 0.0012 19.0 0.0 2.7 2 1 0 2 2 2 2 Papain family cysteine protease DUF4644 PF15486.6 EXF76770.1 - 0.084 12.6 0.3 0.34 10.7 0.0 2.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4644) SRX PF09201.10 EXF76771.1 - 0.061 13.1 0.1 0.1 12.4 0.1 1.5 1 0 0 1 1 1 0 SRX, signal recognition particle receptor alpha subunit NmrA PF05368.13 EXF76773.1 - 9.6e-09 35.1 0.0 2.3e-08 33.9 0.0 1.6 1 1 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EXF76773.1 - 1e-08 35.3 0.0 1.9e-08 34.4 0.0 1.5 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EXF76773.1 - 4.5e-05 23.0 0.0 0.0033 16.9 0.0 2.3 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EXF76773.1 - 0.048 13.1 0.0 2.8 7.3 0.0 2.1 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase 2-Hacid_dh_C PF02826.19 EXF76773.1 - 0.067 12.5 0.0 0.13 11.6 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain RmlD_sub_bind PF04321.17 EXF76773.1 - 0.075 12.1 0.0 0.21 10.7 0.0 1.7 2 0 0 2 2 2 0 RmlD substrate binding domain Citrate_bind PF16114.5 EXF76773.1 - 0.12 11.9 0.0 0.22 11.0 0.0 1.4 1 0 0 1 1 1 0 ATP citrate lyase citrate-binding eIF-5a PF01287.20 EXF76775.1 - 1.9e-06 27.9 0.0 3.2e-06 27.1 0.0 1.4 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold TGF_beta_GS PF08515.12 EXF76775.1 - 0.0099 15.4 0.9 0.02 14.4 0.9 1.5 1 0 0 1 1 1 1 Transforming growth factor beta type I GS-motif NFACT-C PF11923.8 EXF76777.1 - 1.4e-41 140.7 0.8 1.4e-41 140.7 0.8 3.5 3 1 1 4 4 4 1 NFACT protein C-terminal domain NFACT-R_1 PF05670.13 EXF76777.1 - 1.9e-33 115.4 0.0 5.4e-33 113.9 0.0 1.9 1 0 0 1 1 1 1 NFACT protein RNA binding domain FbpA PF05833.11 EXF76777.1 - 5.3e-29 101.3 18.0 5.3e-29 101.3 18.0 2.9 2 1 0 2 2 2 1 Fibronectin-binding protein A N-terminus (FbpA) DUF5590 PF17881.1 EXF76777.1 - 0.12 12.5 0.0 0.32 11.1 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF5590) NUDIX PF00293.28 EXF76778.1 - 8.5e-12 45.3 5.2 1.1e-09 38.4 0.1 2.4 2 0 0 2 2 2 2 NUDIX domain DUF2834 PF11196.8 EXF76778.1 - 0.025 14.9 6.8 0.05 13.9 6.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2834) HET PF06985.11 EXF76779.1 - 6.4e-23 81.7 0.3 1.1e-22 81.0 0.3 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Methyltransf_23 PF13489.6 EXF76780.1 - 1.4e-22 80.3 0.0 4.9e-22 78.5 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF76780.1 - 4.1e-13 49.8 0.0 1.1e-12 48.5 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF76780.1 - 2.1e-11 44.3 0.0 4.7e-11 43.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF76780.1 - 6e-10 39.8 0.0 3.8e-09 37.2 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF76780.1 - 3.7e-09 36.5 0.0 0.0008 19.2 0.0 2.5 2 0 0 2 2 2 2 Methyltransferase domain CMAS PF02353.20 EXF76780.1 - 0.0018 17.6 0.0 0.0032 16.8 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.18 EXF76780.1 - 0.017 14.5 0.0 0.32 10.3 0.0 2.5 2 1 0 2 2 2 0 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.17 EXF76780.1 - 0.032 13.7 0.0 0.067 12.6 0.0 1.5 1 0 0 1 1 1 0 Putative methyltransferase Calpain_inhib PF00748.19 EXF76780.1 - 0.049 14.1 5.6 0.095 13.2 5.6 1.4 1 0 0 1 1 1 0 Calpain inhibitor MTS PF05175.14 EXF76780.1 - 0.094 12.3 0.0 0.76 9.3 0.0 2.1 1 1 0 1 1 1 0 Methyltransferase small domain Methyltransf_2 PF00891.18 EXF76781.1 - 1.2e-25 90.0 0.0 2.1e-25 89.3 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_18 PF12847.7 EXF76781.1 - 0.0069 16.3 0.0 0.014 15.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF76781.1 - 0.071 13.8 0.0 0.2 12.4 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain CheR PF01739.18 EXF76781.1 - 0.14 11.6 0.0 0.25 10.8 0.0 1.3 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain NmrA PF05368.13 EXF76782.1 - 1.3e-14 54.3 0.1 2.9e-14 53.2 0.1 1.6 1 1 0 1 1 1 1 NmrA-like family Epimerase PF01370.21 EXF76782.1 - 3.3e-09 36.6 0.0 2.2e-08 33.9 0.0 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EXF76782.1 - 5.6e-09 36.2 0.0 1.3e-08 35.0 0.0 1.7 1 1 0 1 1 1 1 NAD(P)H-binding Semialdhyde_dh PF01118.24 EXF76782.1 - 0.0009 19.7 0.1 0.002 18.5 0.1 1.6 1 1 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain KR PF08659.10 EXF76782.1 - 0.0037 17.2 0.0 0.0068 16.3 0.0 1.5 1 1 0 1 1 1 1 KR domain RmlD_sub_bind PF04321.17 EXF76782.1 - 0.018 14.2 0.0 0.028 13.5 0.0 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain Sacchrp_dh_NADP PF03435.18 EXF76782.1 - 0.018 15.3 0.0 0.032 14.5 0.0 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 EXF76782.1 - 0.09 12.8 0.1 0.21 11.7 0.0 1.6 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase DapB_N PF01113.20 EXF76782.1 - 0.13 12.4 0.1 0.26 11.4 0.1 1.6 1 1 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus EDR1 PF14381.6 EXF76783.1 - 0.11 12.2 0.4 1.5 8.5 0.3 2.2 1 1 1 2 2 2 0 Ethylene-responsive protein kinase Le-CTR1 Inhibitor_I71 PF12628.7 EXF76785.1 - 0.17 11.7 0.6 0.29 11.0 0.6 1.3 1 0 0 1 1 1 0 Falstatin, cysteine peptidase inhibitor DUF1187 PF06688.11 EXF76785.1 - 0.29 11.5 0.0 0.29 11.5 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1187) Glyco_hydro_35 PF01301.19 EXF76786.1 - 4e-74 250.1 0.0 7.5e-74 249.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 BetaGal_dom2 PF10435.9 EXF76786.1 - 7e-57 192.2 1.3 1.5e-56 191.1 1.3 1.6 1 0 0 1 1 1 1 Beta-galactosidase, domain 2 BetaGal_dom4_5 PF13364.6 EXF76786.1 - 1.1e-51 174.2 5.2 2.1e-31 108.8 0.0 2.9 3 0 0 3 3 3 2 Beta-galactosidase jelly roll domain BetaGal_dom3 PF13363.6 EXF76786.1 - 8.9e-22 76.5 0.0 3.9e-21 74.4 0.0 2.1 2 0 0 2 2 2 1 Beta-galactosidase, domain 3 Glyco_hydro_42 PF02449.15 EXF76786.1 - 1.9e-06 27.5 0.1 0.00041 19.8 0.1 2.4 1 1 1 2 2 2 2 Beta-galactosidase Cellulase PF00150.18 EXF76786.1 - 6.2e-06 25.8 1.7 2.5e-05 23.9 0.0 2.5 3 0 0 3 3 3 1 Cellulase (glycosyl hydrolase family 5) Inhibitor_I36 PF03995.13 EXF76787.1 - 0.031 14.2 0.4 0.031 14.2 0.4 2.1 2 0 0 2 2 2 0 Peptidase inhibitor family I36 LapA_dom PF06305.11 EXF76789.1 - 0.0015 18.3 0.1 0.0028 17.5 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide assembly protein A domain Amnionless PF14828.6 EXF76789.1 - 0.0017 17.3 0.0 0.0023 16.8 0.0 1.1 1 0 0 1 1 1 1 Amnionless Trp_oprn_chp PF09534.10 EXF76789.1 - 0.0041 16.9 0.2 0.0078 16.0 0.2 1.4 1 0 0 1 1 1 1 Tryptophan-associated transmembrane protein (Trp_oprn_chp) DUF2613 PF11021.8 EXF76789.1 - 0.0071 16.4 0.2 0.026 14.6 0.2 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF2613) EphA2_TM PF14575.6 EXF76789.1 - 0.055 14.4 0.0 0.11 13.3 0.0 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Colicin_V PF02674.16 EXF76789.1 - 0.069 13.1 0.0 0.11 12.5 0.0 1.2 1 0 0 1 1 1 0 Colicin V production protein Phage_holin_2_4 PF16082.5 EXF76789.1 - 0.092 12.5 0.8 0.2 11.4 0.8 1.5 1 0 0 1 1 1 0 Bacteriophage holin family, superfamily II-like DUF3042 PF11240.8 EXF76789.1 - 0.14 12.2 0.1 0.32 11.0 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3042) VSP PF03302.13 EXF76789.1 - 1.2 7.9 8.0 2.5 6.9 7.6 1.6 1 1 1 2 2 2 0 Giardia variant-specific surface protein FlgH PF02107.16 EXF76790.1 - 0.44 10.1 3.2 0.67 9.5 3.2 1.2 1 0 0 1 1 1 0 Flagellar L-ring protein CCDC53 PF10152.9 EXF76790.1 - 3.4 8.1 5.0 6.5 7.2 5.0 1.6 1 1 0 1 1 1 0 Subunit CCDC53 of WASH complex CDC27 PF09507.10 EXF76790.1 - 4 6.7 10.5 5.5 6.3 10.5 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Cu-oxidase_2 PF07731.14 EXF76791.1 - 1.2e-44 151.3 4.7 4.6e-40 136.5 0.3 3.6 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.22 EXF76791.1 - 1e-40 139.4 0.7 1.2e-35 123.0 0.1 3.3 3 0 0 3 3 3 2 Multicopper oxidase Cu-oxidase_3 PF07732.15 EXF76791.1 - 1.7e-40 137.7 2.1 1.8e-37 128.0 0.1 3.2 3 0 0 3 3 3 2 Multicopper oxidase Cupredoxin_1 PF13473.6 EXF76791.1 - 0.0098 16.0 0.0 2.9 8.1 0.0 3.3 2 2 1 3 3 3 1 Cupredoxin-like domain DUF5060 PF16586.5 EXF76791.1 - 0.062 13.7 0.0 0.33 11.3 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF5060) C1q PF00386.21 EXF76791.1 - 0.066 13.4 0.0 13 6.0 0.0 2.5 2 0 0 2 2 2 0 C1q domain FTR1 PF03239.14 EXF76792.1 - 1e-74 251.5 10.1 1.2e-74 251.2 10.1 1.0 1 0 0 1 1 1 1 Iron permease FTR1 family Asparaginase PF00710.20 EXF76793.1 - 6.5e-27 94.3 0.0 1e-26 93.6 0.0 1.2 1 0 0 1 1 1 1 Asparaginase, N-terminal Asparaginase_C PF17763.1 EXF76793.1 - 1.3e-12 48.0 0.0 7e-12 45.6 0.0 2.1 1 1 0 1 1 1 1 Glutaminase/Asparaginase C-terminal domain MFS_1 PF07690.16 EXF76796.1 - 2.6e-20 72.6 48.4 7.8e-17 61.2 34.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Tyrosinase PF00264.20 EXF76797.1 - 4.9e-50 170.9 0.3 7.6e-50 170.3 0.3 1.3 1 0 0 1 1 1 1 Common central domain of tyrosinase SAM_2 PF07647.17 EXF76797.1 - 0.093 12.9 0.0 0.26 11.4 0.0 1.7 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) COesterase PF00135.28 EXF76798.1 - 6e-86 289.3 0.1 7.4e-86 289.1 0.1 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EXF76798.1 - 2.2e-07 31.0 0.1 7.7e-07 29.2 0.1 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EXF76798.1 - 0.0043 16.6 0.3 0.0091 15.5 0.3 1.5 1 0 0 1 1 1 1 Prolyl oligopeptidase family Aminotran_1_2 PF00155.21 EXF76799.1 - 4.4e-31 108.4 0.0 1e-30 107.1 0.0 1.5 1 1 1 2 2 2 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EXF76799.1 - 0.014 14.0 0.0 0.021 13.4 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme Aminotran_3 PF00202.21 EXF76800.1 - 3.9e-41 141.1 0.0 6e-19 68.0 0.0 3.1 3 0 0 3 3 3 3 Aminotransferase class-III AAA_26 PF13500.6 EXF76800.1 - 4.8e-15 55.9 0.0 7.7e-15 55.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain COX7C PF02935.16 EXF76802.1 - 0.033 14.4 0.2 0.11 12.8 0.2 1.9 1 0 0 1 1 1 0 Cytochrome c oxidase subunit VIIc DUF805 PF05656.14 EXF76802.1 - 0.069 13.6 5.0 0.17 12.3 0.1 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF805) Bac_export_2 PF01312.19 EXF76802.1 - 0.085 12.1 1.8 0.3 10.2 0.0 2.1 2 0 0 2 2 2 0 FlhB HrpN YscU SpaS Family NAD_binding_4 PF07993.12 EXF76803.1 - 2e-28 99.2 0.0 3e-28 98.7 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein AMP-binding PF00501.28 EXF76803.1 - 5.2e-26 91.2 0.0 7.7e-26 90.6 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme Epimerase PF01370.21 EXF76803.1 - 2.4e-10 40.3 0.0 4.2e-10 39.5 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family PP-binding PF00550.25 EXF76803.1 - 1.1e-06 28.9 0.0 2.3e-06 27.8 0.0 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site Semialdhyde_dh PF01118.24 EXF76803.1 - 0.033 14.6 0.0 0.094 13.2 0.0 1.8 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain GDP_Man_Dehyd PF16363.5 EXF76803.1 - 0.16 11.3 0.0 0.57 9.5 0.0 1.8 1 1 0 1 1 1 0 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 EXF76803.1 - 0.17 11.0 0.0 0.67 9.0 0.0 2.0 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein Pex16 PF08610.10 EXF76805.1 - 2e-142 474.2 0.7 2.2e-142 474.0 0.7 1.0 1 0 0 1 1 1 1 Peroxisomal membrane protein (Pex16) Fungal_trans PF04082.18 EXF76806.1 - 2.3e-22 79.3 0.2 3.9e-22 78.6 0.2 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF76806.1 - 9.7e-08 32.0 12.1 1.8e-07 31.1 12.1 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Brr6_like_C_C PF10104.9 EXF76807.1 - 5e-36 123.4 5.1 6.4e-36 123.1 5.1 1.1 1 0 0 1 1 1 1 Di-sulfide bridge nucleocytoplasmic transport domain PBP1_TM PF14812.6 EXF76807.1 - 0.0074 16.6 3.8 0.037 14.4 1.7 2.8 3 0 0 3 3 3 1 Transmembrane domain of transglycosylase PBP1 at N-terminal Med26 PF08711.11 EXF76808.1 - 5.8e-12 45.4 0.0 1.4e-11 44.3 0.0 1.7 1 0 0 1 1 1 1 TFIIS helical bundle-like domain Pkinase PF00069.25 EXF76809.1 - 2.3e-41 141.9 0.2 6.7e-23 81.4 0.2 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EXF76809.1 - 1.3e-14 54.1 0.3 6.3e-10 38.8 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 EXF76809.1 - 0.092 11.5 0.0 0.16 10.7 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase Chromo PF00385.24 EXF76811.1 - 4.8e-05 23.2 0.1 9.6e-05 22.2 0.1 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Dendrin PF15498.6 EXF76813.1 - 0.33 9.7 3.6 0.33 9.6 3.6 1.1 1 0 0 1 1 1 0 Nephrin and CD2AP-binding protein, Dendrin Fumble PF03630.14 EXF76815.1 - 4.1e-145 483.1 0.0 5e-145 482.8 0.0 1.1 1 0 0 1 1 1 1 Fumble PAN_3 PF08277.12 EXF76816.1 - 0.15 11.9 4.0 0.21 11.4 4.0 1.3 1 0 0 1 1 1 0 PAN-like domain CFEM PF05730.11 EXF76817.1 - 0.00011 22.2 2.8 0.00011 22.2 2.8 2.9 2 0 0 2 2 2 1 CFEM domain bVLRF1 PF18826.1 EXF76818.1 - 1.4e-62 209.9 0.1 2.5e-62 209.2 0.1 1.4 1 0 0 1 1 1 1 bacteroidetes VLRF1 release factor Ank_5 PF13857.6 EXF76818.1 - 4.2e-07 30.1 0.0 1.2e-06 28.7 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 EXF76818.1 - 0.2 12.2 0.4 0.48 11.0 0.4 1.7 1 0 0 1 1 1 0 Ankyrin repeat RPA43_OB PF17875.1 EXF76818.1 - 3 8.5 5.3 4.1 8.1 1.9 2.7 3 0 0 3 3 3 0 RPA43 OB domain in RNA Pol I CBP4 PF07960.11 EXF76818.1 - 5 7.0 8.4 3 7.7 1.5 2.9 2 0 0 2 2 2 0 CBP4 MT0933_antitox PF14013.6 EXF76819.1 - 0.003 17.8 5.5 0.0048 17.2 4.0 2.2 2 1 0 2 2 2 1 MT0933-like antitoxin protein PID PF00640.23 EXF76820.1 - 0.42 10.6 2.8 0.84 9.7 2.8 1.5 1 0 0 1 1 1 0 Phosphotyrosine interaction domain (PTB/PID) Fungal_trans PF04082.18 EXF76821.1 - 2.7e-13 49.6 0.0 5.1e-13 48.7 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain HD_4 PF13328.6 EXF76821.1 - 0.11 12.2 0.7 0.45 10.2 0.0 2.3 3 0 0 3 3 3 0 HD domain F-box-like PF12937.7 EXF76822.1 - 0.00021 21.1 0.1 0.00044 20.1 0.1 1.6 1 0 0 1 1 1 1 F-box-like WD40 PF00400.32 EXF76824.1 - 7.5e-20 70.9 15.3 0.00039 21.2 0.1 6.5 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EXF76824.1 - 3.7e-13 49.6 6.0 4.3e-05 23.7 0.5 4.3 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EXF76824.1 - 8e-08 32.4 0.1 0.00068 19.6 0.1 2.8 2 1 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A PAS_9 PF13426.7 EXF76825.1 - 1.5e-13 50.9 0.1 8.3e-13 48.5 0.0 2.3 3 0 0 3 3 3 1 PAS domain PAS PF00989.25 EXF76825.1 - 0.011 15.7 0.0 0.12 12.4 0.0 2.3 2 0 0 2 2 2 0 PAS fold STAG PF08514.11 EXF76826.1 - 0.039 13.9 0.1 0.066 13.1 0.1 1.3 1 0 0 1 1 1 0 STAG domain ATG16 PF08614.11 EXF76826.1 - 0.04 14.2 1.6 0.082 13.1 1.6 1.5 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) Zw10 PF06248.13 EXF76826.1 - 0.078 11.5 0.1 0.1 11.1 0.1 1.1 1 0 0 1 1 1 0 Centromere/kinetochore Zw10 VPS28 PF03997.12 EXF76826.1 - 0.6 9.7 2.2 1.2 8.7 0.6 2.0 1 1 1 2 2 2 0 VPS28 protein Acetyltransf_1 PF00583.25 EXF76827.1 - 2.2e-13 50.4 0.0 3e-13 50.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EXF76827.1 - 2.5e-10 40.4 0.0 3.8e-10 39.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EXF76827.1 - 4.6e-09 36.6 0.0 6.5e-09 36.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EXF76827.1 - 4.9e-06 26.4 0.0 8.1e-06 25.7 0.0 1.2 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 EXF76827.1 - 0.0026 17.9 0.0 0.0038 17.3 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 EXF76827.1 - 0.003 17.7 0.1 0.0062 16.7 0.1 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain adh_short_C2 PF13561.6 EXF76828.1 - 1.3e-60 204.8 1.9 1.6e-60 204.6 1.9 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF76828.1 - 3e-46 157.4 1.2 3.4e-46 157.2 1.2 1.0 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EXF76828.1 - 5.4e-12 46.0 0.8 7.3e-12 45.6 0.8 1.2 1 0 0 1 1 1 1 KR domain 3HCDH_N PF02737.18 EXF76828.1 - 0.03 14.2 0.1 0.046 13.6 0.1 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Methyltransf_25 PF13649.6 EXF76828.1 - 0.063 14.0 0.0 0.16 12.7 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain ZapC PF07126.12 EXF76828.1 - 0.067 12.8 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 Cell-division protein ZapC DUF1793 PF08760.11 EXF76829.1 - 1.4e-75 253.3 0.8 1.4e-75 253.3 0.8 2.3 3 0 0 3 3 3 1 Domain of unknown function (DUF1793) DUF4965 PF16335.5 EXF76829.1 - 9.7e-68 227.2 0.6 1.6e-52 177.7 0.0 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF4965) DUF5127 PF17168.4 EXF76829.1 - 6.8e-43 147.1 2.0 1.4e-42 146.1 2.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF5127) DUF4964 PF16334.5 EXF76829.1 - 0.00066 19.2 0.1 0.0016 18.0 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4964) Bac_rhamnosid6H PF17389.2 EXF76829.1 - 0.0033 16.7 0.3 1.3 8.2 0.0 2.4 2 0 0 2 2 2 2 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain Glyco_hydr_116N PF12215.8 EXF76829.1 - 0.024 14.1 0.3 0.068 12.6 0.2 1.8 2 0 0 2 2 2 0 beta-glucosidase 2, glycosyl-hydrolase family 116 N-term RRM_1 PF00076.22 EXF76830.1 - 7.1e-21 73.8 0.0 1e-20 73.3 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EXF76830.1 - 3.1e-05 23.6 0.0 4.5e-05 23.0 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Sec39 PF08314.11 EXF76831.1 - 7.8e-285 947.1 0.0 9e-285 946.9 0.0 1.0 1 0 0 1 1 1 1 Secretory pathway protein Sec39 Ndufs5 PF10200.9 EXF76832.1 - 0.00012 22.3 0.1 0.00014 22.1 0.1 1.1 1 0 0 1 1 1 1 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa DUF3128 PF11326.8 EXF76832.1 - 0.0061 16.9 1.4 0.016 15.5 1.3 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF3128) COX6B PF02297.17 EXF76832.1 - 0.025 14.8 0.7 0.038 14.2 0.7 1.3 1 0 0 1 1 1 0 Cytochrome oxidase c subunit VIb Adaptin_N PF01602.20 EXF76834.1 - 6.2e-141 470.5 5.9 7.4e-141 470.3 5.9 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptinC2 PF02883.20 EXF76834.1 - 6.5e-20 71.5 0.0 2.4e-19 69.7 0.0 1.9 1 0 0 1 1 1 1 Adaptin C-terminal domain Cnd1 PF12717.7 EXF76834.1 - 2.6e-09 37.3 7.0 2.8e-06 27.4 0.1 3.9 3 1 2 5 5 5 2 non-SMC mitotic condensation complex subunit 1 DUF3730 PF12530.8 EXF76834.1 - 1.3e-06 28.1 0.2 0.0026 17.4 0.1 2.7 1 1 1 2 2 2 2 Protein of unknown function (DUF3730) HEAT_2 PF13646.6 EXF76834.1 - 7.5e-05 23.0 0.9 1.6 9.2 0.1 4.2 3 2 0 4 4 4 2 HEAT repeats NAD_binding_6 PF08030.12 EXF76834.1 - 7.6e-05 22.9 0.3 0.73 9.9 0.0 3.2 3 0 0 3 3 3 2 Ferric reductase NAD binding domain NAD_binding_1 PF00175.21 EXF76834.1 - 0.0069 17.0 0.1 4.2 8.1 0.0 2.6 2 0 0 2 2 2 2 Oxidoreductase NAD-binding domain HEAT PF02985.22 EXF76834.1 - 0.0072 16.5 1.4 6 7.4 0.1 4.2 3 0 0 3 3 3 1 HEAT repeat TIP120 PF08623.10 EXF76834.1 - 0.18 11.5 0.4 4.1 7.1 0.1 2.7 2 0 0 2 2 2 0 TATA-binding protein interacting (TIP20) EF-hand_1 PF00036.32 EXF76835.1 - 2.4e-41 136.2 12.9 9.5e-10 37.3 0.9 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 EXF76835.1 - 7.9e-36 122.3 6.5 5.2e-19 68.5 2.2 2.3 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 EXF76835.1 - 1.6e-34 117.6 11.6 3e-15 55.8 0.6 4.1 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 EXF76835.1 - 1.6e-30 102.4 8.1 2.3e-09 36.4 0.2 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 EXF76835.1 - 1.4e-25 87.6 10.6 3.2e-06 26.4 0.3 4.3 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.6 EXF76835.1 - 2.4e-16 59.8 0.4 3.1e-09 37.0 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain SPARC_Ca_bdg PF10591.9 EXF76835.1 - 2.6e-09 37.4 0.3 0.0022 18.3 0.1 2.1 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 EXF76835.1 - 5.7e-09 35.9 2.0 0.001 19.0 0.2 2.4 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand UPF0154 PF03672.13 EXF76835.1 - 1.7e-06 27.9 0.1 0.0099 15.9 0.0 2.9 2 1 1 3 3 3 2 Uncharacterised protein family (UPF0154) EFhand_Ca_insen PF08726.10 EXF76835.1 - 9.4e-06 25.6 1.6 3.1e-05 24.0 0.2 2.3 2 1 0 2 2 2 1 Ca2+ insensitive EF hand EF-hand_11 PF08976.11 EXF76835.1 - 0.00013 22.8 0.2 0.003 18.4 0.1 2.1 1 1 1 2 2 2 1 EF-hand domain TerB PF05099.13 EXF76835.1 - 0.00023 21.1 0.9 0.47 10.4 0.0 2.4 1 1 1 2 2 2 2 Tellurite resistance protein TerB Caleosin PF05042.13 EXF76835.1 - 0.00084 19.3 1.8 0.55 10.1 0.0 3.5 1 1 3 4 4 4 1 Caleosin related protein RNA_pol_Rpb4 PF03874.16 EXF76835.1 - 0.0023 18.3 2.2 0.69 10.3 0.2 2.8 3 1 0 3 3 2 2 RNA polymerase Rpb4 Dockerin_1 PF00404.18 EXF76835.1 - 0.0071 16.5 6.6 0.47 10.7 0.7 2.9 1 1 2 3 3 3 2 Dockerin type I domain DUF5580 PF17743.1 EXF76835.1 - 0.0078 14.8 0.0 0.0079 14.8 0.0 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5580) SurA_N_2 PF13623.6 EXF76835.1 - 0.015 15.2 1.1 0.43 10.4 0.1 2.3 1 1 1 2 2 2 0 SurA N-terminal domain EF-hand_14 PF17959.1 EXF76835.1 - 0.019 15.3 0.5 8.1 6.9 0.1 2.4 1 1 1 2 2 2 0 EF-hand domain Syntaxin PF00804.25 EXF76835.1 - 0.023 14.4 1.2 5.1 6.7 0.1 2.2 2 1 0 2 2 2 0 Syntaxin DUF4497 PF14924.6 EXF76835.1 - 0.03 14.8 0.0 11 6.5 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4497) Poly_export PF02563.16 EXF76835.1 - 0.033 14.4 0.0 0.23 11.7 0.0 2.4 2 1 0 2 2 2 0 Polysaccharide biosynthesis/export protein Toprim_4 PF13662.6 EXF76835.1 - 0.047 14.2 0.1 2.3 8.8 0.0 2.4 2 1 0 2 2 2 0 Toprim domain dCache_2 PF08269.11 EXF76835.1 - 0.078 12.1 0.1 1.3 8.1 0.0 2.3 1 1 1 2 2 2 0 Cache domain MotA_activ PF09114.10 EXF76835.1 - 0.087 13.0 0.2 1.2 9.4 0.0 2.3 1 1 0 2 2 2 0 Transcription factor MotA, activation domain RuvA_C PF07499.13 EXF76835.1 - 0.091 13.2 0.1 10 6.6 0.0 3.0 3 0 0 3 3 3 0 RuvA, C-terminal domain RloB PF13707.6 EXF76835.1 - 0.11 12.7 1.1 0.9 9.7 1.1 2.1 1 1 0 1 1 1 0 RloB-like protein DUF5132 PF17195.4 EXF76835.1 - 0.19 11.8 0.5 24 5.1 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF5132) SNARE PF05739.19 EXF76836.1 - 6.1e-16 58.2 0.8 1.2e-15 57.2 0.8 1.6 1 0 0 1 1 1 1 SNARE domain Syntaxin PF00804.25 EXF76836.1 - 3.7e-05 23.5 10.6 0.00036 20.2 10.6 2.0 1 1 0 1 1 1 1 Syntaxin MCPsignal PF00015.21 EXF76836.1 - 0.0074 16.1 7.9 0.27 11.0 1.4 2.6 3 0 0 3 3 3 2 Methyl-accepting chemotaxis protein (MCP) signalling domain Sporozoite_P67 PF05642.11 EXF76836.1 - 0.016 13.3 0.1 0.021 13.0 0.1 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DASH_Dad1 PF08649.10 EXF76836.1 - 1.5 9.1 3.0 8.4 6.7 0.0 2.9 3 0 0 3 3 3 0 DASH complex subunit Dad1 PPR_2 PF13041.6 EXF76837.1 - 9.4e-05 22.5 0.0 0.0015 18.6 0.0 2.4 2 0 0 2 2 2 1 PPR repeat family PPR PF01535.20 EXF76837.1 - 0.0024 18.0 0.0 0.042 14.1 0.0 2.6 2 0 0 2 2 2 1 PPR repeat ANAPC3 PF12895.7 EXF76837.1 - 0.11 12.7 0.0 6.9 7.0 0.0 3.1 3 0 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 COX7a PF02238.15 EXF76838.1 - 3.3e-20 72.2 0.4 4e-20 71.9 0.4 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VII PDH PF02153.17 EXF76838.1 - 0.15 11.0 0.0 0.19 10.7 0.0 1.1 1 0 0 1 1 1 0 Prephenate dehydrogenase Clathrin_lg_ch PF01086.17 EXF76839.1 - 1.6e-74 250.8 4.2 1.8e-74 250.7 4.2 1.0 1 0 0 1 1 1 1 Clathrin light chain DUF4051 PF13260.6 EXF76839.1 - 0.49 10.2 2.1 0.87 9.4 2.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4051) CR6_interact PF10147.9 EXF76839.1 - 0.76 9.5 11.4 0.15 11.8 6.9 1.8 2 0 0 2 2 2 0 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 CTD_bind PF04818.13 EXF76840.1 - 1.2e-16 61.3 0.1 3.2e-16 59.9 0.0 1.9 2 0 0 2 2 2 1 RNA polymerase II-binding domain. CREPT PF16566.5 EXF76840.1 - 0.0097 16.1 0.1 0.024 14.8 0.1 1.6 1 0 0 1 1 1 1 Cell-cycle alteration and expression-elevated protein in tumour ABC_membrane PF00664.23 EXF76841.1 - 3.4e-49 167.9 5.4 4.5e-49 167.5 5.4 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 EXF76841.1 - 5.3e-33 114.4 0.0 1.1e-32 113.5 0.0 1.5 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 EXF76841.1 - 0.00031 20.3 0.1 0.0068 15.9 0.0 2.2 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 EXF76841.1 - 0.004 17.4 0.1 0.029 14.7 0.1 2.2 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 EXF76841.1 - 0.015 15.7 0.3 0.21 12.0 0.3 2.4 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EXF76841.1 - 0.017 15.5 0.1 0.053 13.9 0.1 1.8 1 1 0 1 1 1 0 AAA ATPase domain ABC_ATPase PF09818.9 EXF76841.1 - 0.025 13.4 0.1 0.042 12.6 0.1 1.3 1 0 0 1 1 1 0 Predicted ATPase of the ABC class AAA_5 PF07728.14 EXF76841.1 - 0.07 13.1 0.1 0.27 11.2 0.0 2.0 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_29 PF13555.6 EXF76841.1 - 0.08 12.7 0.1 0.2 11.4 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Sigma54_activ_2 PF14532.6 EXF76841.1 - 0.13 12.4 0.0 0.76 9.9 0.0 2.2 2 0 0 2 2 2 0 Sigma-54 interaction domain DUF4131 PF13567.6 EXF76841.1 - 0.18 11.4 0.6 0.92 9.1 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) IstB_IS21 PF01695.17 EXF76841.1 - 0.22 11.2 0.5 1.7 8.4 0.0 2.4 2 1 1 3 3 3 0 IstB-like ATP binding protein SbcCD_C PF13558.6 EXF76841.1 - 0.26 11.6 1.5 3.1 8.1 1.5 2.5 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit Hydrolase_4 PF12146.8 EXF76842.1 - 5.8e-50 169.8 0.0 7.2e-50 169.5 0.0 1.0 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EXF76842.1 - 7.8e-13 49.5 0.3 9.6e-13 49.2 0.3 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EXF76842.1 - 5.7e-11 42.6 0.2 1.6e-10 41.1 0.2 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Esterase PF00756.20 EXF76842.1 - 0.046 13.4 0.0 0.07 12.8 0.0 1.4 1 1 0 1 1 1 0 Putative esterase DUF900 PF05990.12 EXF76842.1 - 0.19 11.2 0.0 0.3 10.6 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) Cation_efflux PF01545.21 EXF76843.1 - 2.8e-15 56.6 6.9 3.7e-15 56.2 6.9 1.2 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 EXF76843.1 - 3.2e-10 40.0 0.2 8.1e-10 38.7 0.2 1.6 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter DUF2259 PF10016.9 EXF76844.1 - 0.097 12.6 0.1 0.23 11.4 0.1 1.8 1 1 0 1 1 1 0 Predicted secreted protein (DUF2259) Glyco_transf_8 PF01501.20 EXF76845.1 - 2.9e-23 82.8 0.5 6.9e-22 78.2 0.5 2.1 1 1 0 1 1 1 1 Glycosyl transferase family 8 Mannosyl_trans3 PF11051.8 EXF76845.1 - 0.035 13.5 0.0 0.057 12.8 0.0 1.3 1 0 0 1 1 1 0 Mannosyltransferase putative Spt20 PF12090.8 EXF76845.1 - 3.9 7.0 10.2 7.2 6.1 10.2 1.4 1 0 0 1 1 1 0 Spt20 family zf-rbx1 PF12678.7 EXF76846.1 - 1.1e-09 38.4 3.9 2.1e-09 37.5 3.9 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 EXF76846.1 - 1.7e-09 37.9 4.9 3.1e-09 37.0 4.9 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 EXF76846.1 - 4e-06 26.6 2.7 7e-06 25.8 2.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EXF76846.1 - 9.8e-06 25.5 2.2 1.8e-05 24.6 2.2 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 EXF76846.1 - 5.8e-05 23.0 1.9 0.00014 21.7 2.0 1.6 1 1 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EXF76846.1 - 0.00028 20.7 6.8 0.0041 17.0 7.1 2.1 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 EXF76846.1 - 0.00029 20.4 0.4 0.00063 19.3 0.4 1.4 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-C3HC4_2 PF13923.6 EXF76846.1 - 0.0004 20.2 2.3 0.0004 20.2 2.3 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EXF76846.1 - 0.0071 16.4 2.6 0.017 15.1 2.6 1.6 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 EXF76846.1 - 0.014 15.2 4.0 0.036 13.9 4.1 1.6 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_11 PF17123.5 EXF76846.1 - 0.052 13.3 1.5 0.2 11.4 1.5 2.0 1 1 0 1 1 1 0 RING-like zinc finger zf-C3HC4_4 PF15227.6 EXF76846.1 - 0.13 12.5 1.1 0.25 11.5 1.1 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING FANCL_C PF11793.8 EXF76846.1 - 0.28 11.4 1.9 0.76 10.0 1.9 1.7 1 1 0 1 1 1 0 FANCL C-terminal domain zf-RING_4 PF14570.6 EXF76846.1 - 1.3 8.9 3.1 3.1 7.7 3.2 1.6 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain CMD PF02627.20 EXF76847.1 - 0.0011 19.0 0.0 0.0045 17.0 0.0 2.0 3 0 0 3 3 3 1 Carboxymuconolactone decarboxylase family zf-C2H2 PF00096.26 EXF76851.1 - 3.8e-05 23.9 17.8 0.67 10.5 0.9 4.7 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-TAZ PF02135.16 EXF76851.1 - 0.86 10.1 3.3 1.4 9.4 1.0 2.2 2 0 0 2 2 2 0 TAZ zinc finger zf-C2H2_4 PF13894.6 EXF76851.1 - 3 8.9 25.5 0.68 10.9 0.8 5.3 5 1 0 5 5 5 0 C2H2-type zinc finger Methyltransf_23 PF13489.6 EXF76852.1 - 1.2e-22 80.5 0.0 1.6e-22 80.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF76852.1 - 1e-14 55.0 0.0 4.3e-14 53.0 0.0 2.0 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF76852.1 - 1e-12 48.5 0.0 2e-12 47.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF76852.1 - 7.7e-12 45.8 0.0 3.2e-11 43.8 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF76852.1 - 4e-10 39.7 0.0 0.00078 19.3 0.0 2.3 2 1 0 2 2 2 2 Methyltransferase domain Ubie_methyltran PF01209.18 EXF76852.1 - 7.1e-09 35.3 0.0 1.1e-07 31.5 0.0 2.3 2 1 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.17 EXF76852.1 - 7.8e-05 22.2 0.0 0.0026 17.3 0.0 2.6 3 0 0 3 3 3 1 Putative methyltransferase MTS PF05175.14 EXF76852.1 - 0.00036 20.1 0.0 0.0041 16.7 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_16 PF10294.9 EXF76852.1 - 0.0077 16.0 0.0 0.013 15.2 0.0 1.3 1 0 0 1 1 1 1 Lysine methyltransferase PrmA PF06325.13 EXF76852.1 - 0.12 11.8 0.0 0.18 11.1 0.0 1.4 1 1 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) DUF938 PF06080.12 EXF76852.1 - 0.14 11.9 0.0 5.1 6.8 0.0 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF938) ANAPC4_WD40 PF12894.7 EXF76853.1 - 3.1e-10 40.2 0.0 3.4e-05 24.0 0.0 3.7 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EXF76853.1 - 0.00019 22.2 4.2 0.091 13.7 0.1 4.4 5 0 0 5 5 5 2 WD domain, G-beta repeat Ge1_WD40 PF16529.5 EXF76853.1 - 0.0054 15.7 0.0 0.0098 14.9 0.0 1.3 1 0 0 1 1 1 1 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 EXF76853.1 - 0.057 12.7 0.0 0.093 12.0 0.0 1.2 1 0 0 1 1 1 0 WD40-like domain PD40 PF07676.12 EXF76853.1 - 0.15 12.0 0.2 0.96 9.5 0.0 2.3 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat Lactamase_B_2 PF12706.7 EXF76854.1 - 0.00089 18.8 0.1 0.0014 18.2 0.1 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 EXF76854.1 - 0.013 15.4 0.1 0.036 14.0 0.1 1.9 2 1 0 2 2 2 0 Beta-lactamase superfamily domain Fungal_trans_2 PF11951.8 EXF76855.1 - 4.8e-30 104.6 0.3 6.1e-30 104.3 0.3 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF76855.1 - 4.9e-08 33.0 6.5 4.9e-08 33.0 6.5 2.5 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.16 EXF76856.1 - 2.7e-34 118.7 32.3 2.7e-34 118.7 32.3 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF76856.1 - 1.9e-08 33.6 11.1 1.9e-08 33.6 11.1 2.4 2 1 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 EXF76856.1 - 2.4e-08 32.9 0.8 4.3e-08 32.1 0.8 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF3523 PF12037.8 EXF76856.1 - 0.22 10.9 0.3 0.4 10.0 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3523) Oxidored_q5_N PF01059.17 EXF76856.1 - 9.7 6.3 8.0 0.44 10.7 1.1 2.4 2 1 1 3 3 3 0 NADH-ubiquinone oxidoreductase chain 4, amino terminus SIS PF01380.22 EXF76857.1 - 3.4e-12 46.3 0.0 5.6e-12 45.6 0.0 1.4 1 0 0 1 1 1 1 SIS domain ALO PF04030.14 EXF76858.1 - 7e-86 288.3 0.5 9e-86 287.9 0.5 1.1 1 0 0 1 1 1 1 D-arabinono-1,4-lactone oxidase FAD_binding_4 PF01565.23 EXF76858.1 - 2.4e-28 98.6 0.0 4.2e-28 97.8 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain Aldo_ket_red PF00248.21 EXF76859.1 - 4.4e-50 170.5 0.0 7.9e-50 169.7 0.0 1.4 1 0 0 1 1 1 1 Aldo/keto reductase family AAA_22 PF13401.6 EXF76859.1 - 2.4e-06 27.9 0.0 7e-06 26.4 0.0 1.8 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 EXF76859.1 - 1.2e-05 25.3 0.0 3.5e-05 23.8 0.0 1.8 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 EXF76859.1 - 0.0002 21.8 0.0 0.00051 20.5 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain NB-ARC PF00931.22 EXF76859.1 - 0.00085 18.6 0.1 0.0022 17.3 0.0 1.7 2 0 0 2 2 2 1 NB-ARC domain Helo_like_N PF17111.5 EXF76859.1 - 0.0017 17.7 0.0 0.0057 16.1 0.0 1.9 1 0 0 1 1 1 1 Fungal N-terminal domain of STAND proteins Ank_2 PF12796.7 EXF76859.1 - 0.015 15.9 0.0 0.28 11.8 0.0 3.1 1 1 0 1 1 1 0 Ankyrin repeats (3 copies) AAA PF00004.29 EXF76859.1 - 0.087 13.2 0.0 0.36 11.3 0.0 2.1 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DUF2075 PF09848.9 EXF76859.1 - 0.1 11.8 0.0 0.21 10.8 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) ERG4_ERG24 PF01222.17 EXF76860.1 - 8.1e-153 509.2 4.5 9.2e-153 509.0 4.5 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.12 EXF76860.1 - 0.00042 19.9 0.8 0.001 18.7 0.2 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1295) Peptidase_M28 PF04389.17 EXF76861.1 - 2.5e-42 144.8 0.0 4.6e-42 144.0 0.0 1.4 2 0 0 2 2 2 1 Peptidase family M28 PA PF02225.22 EXF76861.1 - 6.1e-11 42.2 0.1 2.1e-10 40.5 0.1 2.0 2 0 0 2 2 2 1 PA domain Peptidase_M20 PF01546.28 EXF76861.1 - 1.7e-06 27.9 0.0 2.9e-06 27.1 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Glyco_hydro_61 PF03443.14 EXF76862.1 - 8.9e-43 146.6 2.0 1e-22 81.1 0.0 2.0 1 1 1 2 2 2 2 Glycosyl hydrolase family 61 Glyco_hydro_28 PF00295.17 EXF76863.1 - 1.9e-122 408.4 23.4 2.1e-122 408.2 23.4 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 Cu-oxidase_3 PF07732.15 EXF76864.1 - 3.9e-40 136.6 1.2 3.9e-40 136.6 1.2 2.1 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 EXF76864.1 - 6.1e-37 126.4 10.3 6.9e-35 119.8 0.7 3.4 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.22 EXF76864.1 - 1.5e-30 106.4 0.2 3e-28 98.9 0.0 3.3 3 0 0 3 3 3 1 Multicopper oxidase Phosphoesterase PF04185.14 EXF76865.1 - 1.6e-33 116.4 3.1 2.4e-31 109.2 1.5 2.9 1 1 1 2 2 2 2 Phosphoesterase family VIT1 PF01988.19 EXF76866.1 - 1.6e-62 211.2 0.8 2.1e-62 210.8 0.8 1.1 1 0 0 1 1 1 1 VIT family adh_short PF00106.25 EXF76867.1 - 2.7e-20 72.7 0.1 4.4e-20 72.0 0.1 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF76867.1 - 2.7e-12 46.7 0.6 4.1e-12 46.2 0.6 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF76867.1 - 1.5e-06 28.3 0.4 2.3e-06 27.6 0.2 1.5 2 0 0 2 2 2 1 KR domain Epimerase PF01370.21 EXF76867.1 - 0.00013 21.5 0.1 0.00025 20.6 0.1 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EXF76867.1 - 0.0062 16.0 0.0 0.012 15.1 0.0 1.5 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Peptidase_S28 PF05577.12 EXF76868.1 - 8.8e-43 146.7 0.8 5.8e-42 144.0 0.8 1.9 1 1 0 1 1 1 1 Serine carboxypeptidase S28 DUF2920 PF11144.8 EXF76868.1 - 0.00083 18.6 0.0 0.0012 18.1 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2920) Peptidase_S37 PF05576.11 EXF76868.1 - 0.013 14.2 0.5 0.55 8.8 0.0 2.3 2 0 0 2 2 2 0 PS-10 peptidase S37 NDUF_B7 PF05676.13 EXF76869.1 - 2.2e-29 100.9 3.1 2.6e-29 100.7 3.1 1.1 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) Cmc1 PF08583.10 EXF76869.1 - 0.0012 18.8 1.4 0.0014 18.6 0.9 1.4 1 1 1 2 2 2 1 Cytochrome c oxidase biogenesis protein Cmc1 like Voltage_CLC PF00654.20 EXF76870.1 - 1.2e-85 287.8 16.3 1.2e-85 287.8 16.3 2.0 2 1 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.28 EXF76870.1 - 0.00085 19.7 0.1 0.0022 18.4 0.1 1.7 1 0 0 1 1 1 1 CBS domain DUF2062 PF09835.9 EXF76870.1 - 0.0016 18.3 0.3 0.0016 18.3 0.3 2.6 3 0 0 3 3 3 1 Uncharacterized protein conserved in bacteria (DUF2062) CnrY PF17524.2 EXF76870.1 - 0.05 13.8 1.5 6.6 7.0 0.0 3.2 3 0 0 3 3 3 0 Anti-sigma factor CnrY LacI PF00356.21 EXF76870.1 - 0.14 11.9 5.2 0.39 10.6 0.3 2.4 2 0 0 2 2 2 0 Bacterial regulatory proteins, lacI family DEAD PF00270.29 EXF76871.1 - 0.045 13.5 0.0 0.066 13.0 0.0 1.2 1 0 0 1 1 1 0 DEAD/DEAH box helicase FHA PF00498.26 EXF76871.1 - 0.13 12.6 0.0 0.23 11.8 0.0 1.4 1 0 0 1 1 1 0 FHA domain SGL PF08450.12 EXF76872.1 - 1.3e-26 93.7 0.0 2.7e-26 92.7 0.0 1.5 1 1 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Arylesterase PF01731.20 EXF76872.1 - 0.00024 21.2 0.0 0.00057 20.0 0.0 1.6 1 0 0 1 1 1 1 Arylesterase NHL PF01436.21 EXF76872.1 - 0.0019 18.2 0.4 0.26 11.4 0.0 3.4 3 0 0 3 3 3 1 NHL repeat Str_synth PF03088.16 EXF76872.1 - 0.029 14.5 0.0 0.12 12.6 0.0 1.9 1 1 0 1 1 1 0 Strictosidine synthase Abhydrolase_3 PF07859.13 EXF76873.1 - 2.6e-45 154.9 0.0 8.2e-45 153.3 0.0 1.8 3 0 0 3 3 3 1 alpha/beta hydrolase fold COesterase PF00135.28 EXF76873.1 - 2e-07 30.3 0.0 4.3e-07 29.2 0.0 1.4 1 1 0 1 1 1 1 Carboxylesterase family DUF5094 PF17015.5 EXF76874.1 - 0.02 15.0 2.2 0.023 14.8 2.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5094) Topoisom_I PF01028.20 EXF76874.1 - 0.022 14.0 0.9 0.029 13.6 0.9 1.1 1 0 0 1 1 1 0 Eukaryotic DNA topoisomerase I, catalytic core HAD_2 PF13419.6 EXF76875.1 - 3.5e-24 85.9 0.0 5.1e-24 85.3 0.0 1.3 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EXF76875.1 - 1.4e-12 48.4 0.0 5.7e-12 46.4 0.0 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EXF76875.1 - 4.5e-06 26.6 0.0 7.8e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like NIF PF03031.18 EXF76875.1 - 0.0013 18.6 0.0 0.079 12.7 0.0 2.4 1 1 0 1 1 1 1 NLI interacting factor-like phosphatase HAD PF12710.7 EXF76875.1 - 0.0021 18.5 0.0 0.0036 17.7 0.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Prefoldin PF02996.17 EXF76875.1 - 0.066 13.1 0.1 0.11 12.4 0.1 1.3 1 0 0 1 1 1 0 Prefoldin subunit Hypoth_Ymh PF09509.10 EXF76875.1 - 0.079 12.9 0.1 0.2 11.5 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (Hypoth_ymh) DLH PF01738.18 EXF76876.1 - 5.2e-26 91.5 0.0 5.9e-26 91.4 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Peptidase_S9 PF00326.21 EXF76876.1 - 0.00021 20.8 0.0 0.00035 20.1 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 EXF76876.1 - 0.19 10.9 0.0 0.31 10.2 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Peptidase_S8 PF00082.22 EXF76877.1 - 1.3e-27 96.9 4.7 1.9e-27 96.3 4.7 1.2 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 EXF76877.1 - 1.6e-11 44.7 0.0 3.3e-11 43.7 0.0 1.5 1 0 0 1 1 1 1 Peptidase inhibitor I9 Glyco_hydro_28 PF00295.17 EXF76880.1 - 1.6e-26 93.1 2.8 2.1e-26 92.8 2.8 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 Pectate_lyase_3 PF12708.7 EXF76880.1 - 1.1e-07 31.9 10.1 9.6e-07 28.9 4.4 3.2 1 1 1 2 2 2 1 Pectate lyase superfamily protein Sulfatase PF00884.23 EXF76881.1 - 1e-44 153.2 0.7 1.1e-42 146.5 0.0 2.9 2 2 0 2 2 2 1 Sulfatase DUF4976 PF16347.5 EXF76881.1 - 1.4e-07 31.8 4.3 1.9e-07 31.2 0.8 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF4976) Phosphodiest PF01663.22 EXF76881.1 - 1.6e-07 31.2 0.8 7.7e-06 25.7 0.0 2.7 2 2 0 2 2 2 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase_C PF14707.6 EXF76881.1 - 0.0015 19.3 0.0 0.0036 18.0 0.0 1.7 1 0 0 1 1 1 1 C-terminal region of aryl-sulfatase DUF1501 PF07394.12 EXF76881.1 - 0.0046 16.1 0.0 0.0089 15.1 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1501) DUF229 PF02995.17 EXF76881.1 - 0.017 13.8 0.0 0.021 13.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF229) DUF4994 PF16385.5 EXF76881.1 - 0.086 12.8 0.1 0.16 11.9 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function Spectrin_like PF18373.1 EXF76881.1 - 0.17 12.0 0.0 0.32 11.1 0.0 1.4 1 0 0 1 1 1 0 Spectrin like domain MFS_1 PF07690.16 EXF76882.1 - 4.2e-17 62.1 17.8 6e-17 61.6 17.8 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF1289 PF06945.13 EXF76882.1 - 0.22 11.3 0.2 0.5 10.2 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1289) p450 PF00067.22 EXF76883.1 - 2.9e-62 210.9 0.0 3.9e-62 210.5 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 FAD_binding_1 PF00667.20 EXF76884.1 - 3.6e-43 147.7 0.0 6.3e-43 146.9 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 EXF76884.1 - 1.4e-32 112.9 0.5 6.4e-31 107.5 0.0 2.6 3 0 0 3 3 3 1 Flavodoxin NAD_binding_1 PF00175.21 EXF76884.1 - 6.3e-21 75.1 0.0 1.4e-20 74.0 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain PGF-CTERM PF18204.1 EXF76884.1 - 4.4 7.4 6.3 9.3 6.4 6.3 1.6 1 0 0 1 1 1 0 PGF-CTERM motif Sugar_tr PF00083.24 EXF76885.1 - 1.7e-105 353.5 27.5 2e-105 353.3 27.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF76885.1 - 5.2e-33 114.4 25.6 5.2e-33 114.4 25.6 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily Glyco_hydro_115 PF15979.5 EXF76886.1 - 2.3e-133 444.8 0.6 3.1e-133 444.4 0.6 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 115 GH115_C PF17829.1 EXF76886.1 - 4.7e-40 137.2 0.0 9.3e-40 136.3 0.0 1.5 1 0 0 1 1 1 1 Gylcosyl hydrolase family 115 C-terminal domain BcsB PF03170.13 EXF76886.1 - 0.0013 17.2 0.1 0.0065 14.9 0.1 1.8 1 1 1 2 2 2 1 Bacterial cellulose synthase subunit Glyco_hydro_67N PF03648.14 EXF76886.1 - 0.13 12.6 0.0 0.45 10.8 0.0 2.0 1 0 0 1 1 1 0 Glycosyl hydrolase family 67 N-terminus MFS_1 PF07690.16 EXF76887.1 - 4.2e-28 98.3 28.0 4.2e-28 98.3 28.0 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily MWFE PF15879.5 EXF76887.1 - 0.12 12.6 4.2 4 7.7 0.1 3.8 3 0 0 3 3 3 0 NADH-ubiquinone oxidoreductase MWFE subunit Glyco_hydro_38N PF01074.22 EXF76888.1 - 2.2e-85 286.5 0.2 3.9e-85 285.7 0.2 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.13 EXF76888.1 - 5.6e-51 173.6 0.0 9.7e-51 172.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.11 EXF76888.1 - 6.9e-26 90.2 0.0 1.8e-25 88.9 0.0 1.8 1 0 0 1 1 1 1 Alpha mannosidase middle domain Glyco_hydro38C2 PF17677.1 EXF76888.1 - 8.1e-10 38.7 0.0 2.4e-09 37.2 0.0 1.9 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal beta sandwich domain Methyltransf_23 PF13489.6 EXF76889.1 - 2.7e-10 40.3 0.0 4.9e-10 39.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF76889.1 - 5e-06 27.1 0.0 7e-05 23.4 0.0 2.6 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF76889.1 - 0.0019 18.9 0.0 0.014 16.0 0.0 2.5 3 0 0 3 3 3 1 Methyltransferase domain TPMT PF05724.11 EXF76889.1 - 0.021 14.5 0.0 0.042 13.5 0.0 1.4 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) Methyltransf_31 PF13847.6 EXF76889.1 - 0.15 11.9 0.0 1.5 8.6 0.0 2.2 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.12 EXF76889.1 - 0.15 12.8 0.0 1.3 9.8 0.0 2.4 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.6 EXF76890.1 - 1.9e-19 70.1 0.0 4.5e-19 68.9 0.0 1.6 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF76890.1 - 6.7e-12 46.0 0.0 1.5e-11 44.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF76890.1 - 4.3e-10 40.1 0.0 8.8e-10 39.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF76890.1 - 2.3e-08 34.0 0.0 2.2e-07 30.8 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF76890.1 - 2.3e-06 28.3 0.0 1.1e-05 26.1 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.19 EXF76890.1 - 0.00026 21.1 0.0 0.00052 20.2 0.0 1.4 1 1 0 1 1 1 1 FtsJ-like methyltransferase CheR PF01739.18 EXF76890.1 - 0.012 15.1 0.0 0.17 11.3 0.0 2.2 2 0 0 2 2 2 0 CheR methyltransferase, SAM binding domain CMAS PF02353.20 EXF76890.1 - 0.025 13.9 0.0 0.052 12.8 0.0 1.4 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase MTS PF05175.14 EXF76890.1 - 0.072 12.6 0.0 0.33 10.5 0.0 1.9 1 1 0 1 1 1 0 Methyltransferase small domain Ubie_methyltran PF01209.18 EXF76890.1 - 0.16 11.3 0.0 0.74 9.1 0.0 2.0 3 0 0 3 3 3 0 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.17 EXF76890.1 - 0.2 11.1 0.0 0.79 9.2 0.0 1.8 2 0 0 2 2 2 0 Putative methyltransferase Podoplanin PF05808.11 EXF76891.1 - 0.0014 18.8 0.7 0.0021 18.2 0.7 1.2 1 0 0 1 1 1 1 Podoplanin Alpha_GJ PF03229.13 EXF76891.1 - 0.0048 17.4 5.4 0.0092 16.5 5.4 1.4 1 0 0 1 1 1 1 Alphavirus glycoprotein J GPI-anchored PF10342.9 EXF76891.1 - 0.0063 17.3 0.3 0.0063 17.3 0.3 1.9 2 0 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Rax2 PF12768.7 EXF76891.1 - 0.017 14.6 0.0 0.028 13.9 0.0 1.3 1 0 0 1 1 1 0 Cortical protein marker for cell polarity ABC2_membrane_3 PF12698.7 EXF76891.1 - 0.019 14.1 0.0 0.019 14.1 0.0 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein DUF4690 PF15756.5 EXF76891.1 - 0.019 15.6 3.0 0.033 14.8 3.0 1.4 1 0 0 1 1 1 0 Small Novel Rich in Cartilage TMEM154 PF15102.6 EXF76891.1 - 0.038 13.9 0.3 0.056 13.3 0.3 1.3 1 0 0 1 1 1 0 TMEM154 protein family Ank_2 PF12796.7 EXF76892.1 - 0.00081 19.9 0.0 0.035 14.7 0.0 2.6 1 1 1 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EXF76892.1 - 0.0091 16.4 0.0 0.055 14.1 0.0 2.4 1 0 0 1 1 1 1 Ankyrin repeat Ank_4 PF13637.6 EXF76892.1 - 0.0093 16.5 0.0 0.072 13.7 0.0 2.6 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 EXF76892.1 - 0.028 14.7 0.1 0.21 11.9 0.0 2.5 2 0 0 2 2 2 0 Ankyrin repeats (many copies) Ank PF00023.30 EXF76892.1 - 0.066 13.7 0.2 0.31 11.6 0.0 2.3 2 0 0 2 2 2 0 Ankyrin repeat DNA_primase_lrg PF04104.14 EXF76893.1 - 4.1e-81 272.3 0.0 6.3e-81 271.7 0.0 1.3 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase, large subunit Velvet PF11754.8 EXF76894.1 - 3.6e-49 168.0 0.0 2.1e-31 109.8 0.0 3.8 2 2 1 3 3 3 2 Velvet factor UBA2_C PF16195.5 EXF76895.1 - 0.37 11.5 5.4 9.9 6.9 0.4 2.9 2 0 0 2 2 2 0 SUMO-activating enzyme subunit 2 C-terminus Fungal_trans_2 PF11951.8 EXF76898.1 - 4.1e-07 29.1 0.1 5.8e-07 28.7 0.1 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Glyco_hydro_cc PF11790.8 EXF76899.1 - 1.9e-55 188.0 2.7 2.5e-55 187.7 2.7 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core NUDE_C PF04880.13 EXF76899.1 - 0.15 12.6 8.1 0.24 11.8 8.1 1.3 1 0 0 1 1 1 0 NUDE protein, C-terminal conserved region DUF863 PF05904.11 EXF76899.1 - 0.27 9.6 1.7 0.38 9.2 1.7 1.1 1 0 0 1 1 1 0 Plant protein of unknown function (DUF863) Cnd2 PF05786.14 EXF76901.1 - 0 1048.5 8.9 0 1048.3 8.9 1.0 1 0 0 1 1 1 1 Condensin complex subunit 2 CNDH2_N PF06278.11 EXF76901.1 - 0.031 14.5 0.0 0.031 14.5 0.0 2.5 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal TraH_2 PF06871.11 EXF76901.1 - 0.2 11.2 3.9 0.46 10.1 3.9 1.6 1 0 0 1 1 1 0 TraH_2 BSP_II PF05432.11 EXF76901.1 - 0.25 11.0 13.6 1.6 8.3 4.7 2.4 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) Na_Ca_ex PF01699.24 EXF76902.1 - 1.9e-52 177.2 41.3 1.2e-27 96.7 18.6 2.7 2 0 0 2 2 2 2 Sodium/calcium exchanger protein DUF5592 PF17332.2 EXF76902.1 - 0.017 15.7 0.2 0.017 15.7 0.2 3.0 3 0 0 3 3 3 0 Family of unknown function (DUF5592) PMM PF03332.13 EXF76904.1 - 2.5e-103 344.6 0.3 2.9e-103 344.4 0.3 1.0 1 0 0 1 1 1 1 Eukaryotic phosphomannomutase Hydrolase_3 PF08282.12 EXF76904.1 - 0.00028 20.7 0.0 0.0011 18.7 0.0 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase WW PF00397.26 EXF76905.1 - 2.5e-10 40.2 0.1 6.5e-10 38.9 0.1 1.8 1 0 0 1 1 1 1 WW domain PhoD PF09423.10 EXF76905.1 - 0.0011 18.1 0.5 0.013 14.5 0.5 2.1 1 1 0 1 1 1 1 PhoD-like phosphatase Homeobox_KN PF05920.11 EXF76908.1 - 3.9e-22 77.9 0.6 8.3e-22 76.8 0.6 1.6 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 EXF76908.1 - 9.9e-09 34.9 1.4 2.6e-08 33.6 1.4 1.7 1 0 0 1 1 1 1 Homeodomain TMEMspv1-c74-12 PF11044.8 EXF76910.1 - 0.0083 16.1 0.6 0.55 10.3 0.1 2.2 2 0 0 2 2 2 2 Plectrovirus spv1-c74 ORF 12 transmembrane protein DUF202 PF02656.15 EXF76910.1 - 0.092 13.2 0.1 0.15 12.5 0.1 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF202) Sod_Cu PF00080.20 EXF76911.1 - 2.2e-08 34.4 0.1 3.1e-08 33.9 0.1 1.3 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) DUF202 PF02656.15 EXF76913.1 - 0.00013 22.3 2.8 0.00013 22.3 2.8 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF202) zf-C2H2 PF00096.26 EXF76914.1 - 0.0027 18.1 21.1 0.0033 17.8 0.5 4.2 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EXF76914.1 - 0.0059 17.4 0.7 0.0059 17.4 0.7 4.1 4 0 0 4 4 4 1 C2H2-type zinc finger zf-C2H2_2 PF12756.7 EXF76914.1 - 0.0079 16.5 1.3 0.024 15.0 1.3 1.7 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) FOXP-CC PF16159.5 EXF76914.1 - 2.5 8.8 8.2 4.4 8.0 1.0 3.0 1 1 1 2 2 2 0 FOXP coiled-coil domain zf-C2H2_6 PF13912.6 EXF76914.1 - 3.9 7.6 6.6 0.23 11.5 0.8 2.0 2 0 0 2 2 2 0 C2H2-type zinc finger Glyco_hydro_31 PF01055.26 EXF76915.1 - 1.6e-100 337.4 0.1 5.4e-100 335.6 0.1 1.7 1 1 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 EXF76915.1 - 1.1e-08 35.3 0.6 2.5e-08 34.1 0.6 1.7 1 0 0 1 1 1 1 Galactose mutarotase-like ATS3 PF06232.11 EXF76915.1 - 0.095 12.6 0.4 5.1 7.0 0.0 2.9 3 0 0 3 3 3 0 Embryo-specific protein 3, (ATS3) PLDc_N PF13396.6 EXF76916.1 - 2e-11 43.6 3.4 2e-11 43.6 3.4 1.5 2 0 0 2 2 2 1 Phospholipase_D-nuclease N-terminal DUF2207 PF09972.9 EXF76916.1 - 0.05 12.4 0.7 0.058 12.2 0.7 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Pox_A14 PF05767.12 EXF76916.1 - 0.064 13.4 0.2 0.095 12.9 0.2 1.2 1 0 0 1 1 1 0 Poxvirus virion envelope protein A14 OPT PF03169.15 EXF76917.1 - 3.7e-81 273.6 12.9 1.1e-58 199.4 4.8 2.0 1 1 1 2 2 2 2 OPT oligopeptide transporter protein Aminotran_5 PF00266.19 EXF76918.1 - 5.6e-08 32.1 0.0 4.4e-07 29.2 0.0 2.0 2 0 0 2 2 2 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 EXF76918.1 - 0.01 15.2 0.0 0.016 14.6 0.0 1.2 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family IDO PF01231.18 EXF76919.1 - 1.5e-153 511.7 0.0 1.7e-153 511.5 0.0 1.0 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase DUF1864 PF08933.11 EXF76919.1 - 8.1e-05 21.5 0.0 0.0027 16.5 0.0 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF1864) Fungal_trans PF04082.18 EXF76920.1 - 5.3e-05 22.4 0.0 9.1e-05 21.6 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Fungal_trans PF04082.18 EXF76921.1 - 8.4e-19 67.6 0.4 1.2e-18 67.1 0.4 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain DUF5345 PF17280.2 EXF76922.1 - 0.12 12.3 0.0 0.23 11.5 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5345) Fungal_trans PF04082.18 EXF76923.1 - 1.8e-10 40.3 0.1 3.5e-10 39.3 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF76923.1 - 3.2e-05 24.0 8.1 8.4e-05 22.6 8.1 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Amidohydro_2 PF04909.14 EXF76924.1 - 3.1e-36 125.7 0.3 4e-36 125.3 0.3 1.1 1 0 0 1 1 1 1 Amidohydrolase DUF4027 PF13219.6 EXF76924.1 - 0.18 11.7 0.1 0.38 10.6 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4027) A_deaminase PF00962.22 EXF76925.1 - 1e-21 77.7 0.0 3.2e-21 76.0 0.0 1.8 2 0 0 2 2 2 1 Adenosine/AMP deaminase Sec5 PF15469.6 EXF76926.1 - 0.11 12.3 0.0 0.28 10.9 0.0 1.7 1 0 0 1 1 1 0 Exocyst complex component Sec5 NmrA PF05368.13 EXF76927.1 - 1.8e-53 181.5 0.0 8.4e-53 179.3 0.0 1.9 1 1 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EXF76927.1 - 7.5e-14 52.0 0.0 1.1e-13 51.5 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 EXF76927.1 - 1.2e-05 24.5 0.0 1.7e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family AdoHcyase_NAD PF00670.21 EXF76927.1 - 0.092 12.8 0.0 0.16 12.0 0.0 1.3 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain DLH PF01738.18 EXF76928.1 - 6.1e-06 25.9 0.1 2.4e-05 24.0 0.1 1.8 1 1 0 1 1 1 1 Dienelactone hydrolase family Hydrolase_4 PF12146.8 EXF76928.1 - 0.0017 17.7 0.0 0.0034 16.7 0.0 1.5 1 1 0 1 1 1 1 Serine aminopeptidase, S33 AXE1 PF05448.12 EXF76928.1 - 0.006 15.3 0.1 0.011 14.5 0.1 1.4 1 0 0 1 1 1 1 Acetyl xylan esterase (AXE1) BAAT_C PF08840.11 EXF76928.1 - 0.016 15.2 0.0 0.024 14.6 0.0 1.3 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal Peptidase_S9 PF00326.21 EXF76928.1 - 0.24 10.8 0.0 2 7.8 0.0 2.3 2 1 0 2 2 2 0 Prolyl oligopeptidase family adh_short PF00106.25 EXF76929.1 - 1.8e-20 73.3 0.1 2e-20 73.1 0.1 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF76929.1 - 1.1e-15 57.9 0.1 1.4e-15 57.5 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF76929.1 - 4e-11 43.2 0.2 6e-11 42.6 0.2 1.1 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EXF76929.1 - 0.00015 21.0 0.0 0.0002 20.6 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.21 EXF76929.1 - 0.00081 18.9 0.1 0.00099 18.6 0.1 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EXF76929.1 - 0.0061 16.0 0.0 0.0071 15.8 0.0 1.1 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Shikimate_DH PF01488.20 EXF76929.1 - 0.063 13.3 0.0 0.086 12.9 0.0 1.2 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase ThiF PF00899.21 EXF76929.1 - 0.15 11.4 0.5 0.35 10.2 0.3 1.6 1 1 0 2 2 2 0 ThiF family adh_short PF00106.25 EXF76930.1 - 7.9e-07 28.7 0.0 9.6e-07 28.4 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase Polysacc_synt_2 PF02719.15 EXF76930.1 - 0.00023 20.4 0.0 0.00028 20.1 0.0 1.0 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein KR PF08659.10 EXF76930.1 - 0.012 15.5 0.0 0.014 15.3 0.0 1.1 1 0 0 1 1 1 0 KR domain adh_short_C2 PF13561.6 EXF76930.1 - 0.026 14.1 0.0 0.032 13.8 0.0 1.1 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase Mvb12 PF09452.10 EXF76930.1 - 0.07 13.6 0.0 0.1 13.0 0.0 1.3 1 0 0 1 1 1 0 ESCRT-I subunit Mvb12 CagE_TrbE_VirB PF03135.14 EXF76930.1 - 0.15 12.1 0.0 0.26 11.3 0.0 1.5 1 1 0 1 1 1 0 CagE, TrbE, VirB family, component of type IV transporter system FerA PF08165.11 EXF76930.1 - 0.15 12.0 0.3 0.45 10.5 0.3 1.7 1 1 0 1 1 1 0 FerA (NUC095) domain RAI16-like PF10257.9 EXF76932.1 - 7.9e-72 242.1 3.9 1.4e-71 241.3 3.9 1.4 1 0 0 1 1 1 1 Retinoic acid induced 16-like protein Katanin_con80 PF13925.6 EXF76932.1 - 0.1 12.6 0.6 0.81 9.7 0.1 2.5 3 0 0 3 3 3 0 con80 domain of Katanin TPP_enzyme_N PF02776.18 EXF76932.1 - 0.15 11.7 0.1 0.57 9.8 0.0 2.1 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain Podoplanin PF05808.11 EXF76936.1 - 0.045 13.8 0.0 0.081 13.0 0.0 1.3 1 0 0 1 1 1 0 Podoplanin VSP PF03302.13 EXF76936.1 - 0.069 12.0 0.0 0.099 11.5 0.0 1.1 1 0 0 1 1 1 0 Giardia variant-specific surface protein Fungal_trans_2 PF11951.8 EXF76937.1 - 3.1e-08 32.9 0.2 5.2e-08 32.1 0.2 1.6 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF76937.1 - 1.6e-07 31.3 8.8 4e-07 30.0 8.8 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain OPT PF03169.15 EXF76938.1 - 1.3e-178 595.5 50.0 1.5e-178 595.3 50.0 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein DUF3093 PF11292.8 EXF76938.1 - 6.1 7.1 8.1 6.3 7.1 4.1 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3093) Amidohydro_3 PF07969.11 EXF76939.1 - 7e-18 65.3 1.0 3e-10 40.2 0.0 2.8 3 0 0 3 3 3 2 Amidohydrolase family Amidohydro_1 PF01979.20 EXF76939.1 - 2.3e-13 50.2 0.0 3.3e-11 43.1 0.0 2.4 2 0 0 2 2 2 2 Amidohydrolase family DUF282 PF03380.14 EXF76941.1 - 4.7 7.2 6.8 15 5.6 1.2 2.7 3 1 0 3 3 3 0 Caenorhabditis protein of unknown function, DUF282 NAD_binding_2 PF03446.15 EXF76942.1 - 5.3e-25 88.4 0.1 8.3e-25 87.8 0.1 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 EXF76942.1 - 1.9e-08 34.6 0.1 3.2e-08 33.9 0.1 1.4 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase F420_oxidored PF03807.17 EXF76942.1 - 0.0034 17.9 0.0 0.01 16.4 0.0 1.8 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.20 EXF76942.1 - 0.086 12.9 0.0 0.15 12.1 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase FAD_binding_3 PF01494.19 EXF76943.1 - 5.9e-21 75.1 0.1 6.3e-14 52.0 0.0 2.3 2 1 0 2 2 2 2 FAD binding domain Pyr_redox_2 PF07992.14 EXF76943.1 - 5.5e-07 29.1 0.0 3.6e-05 23.1 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EXF76943.1 - 2.3e-05 23.7 0.4 3.6e-05 23.0 0.4 1.3 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 EXF76943.1 - 4e-05 23.8 0.3 9.8e-05 22.5 0.3 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EXF76943.1 - 0.00022 21.0 1.2 0.0004 20.1 1.2 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_oxidored PF12831.7 EXF76943.1 - 0.0068 15.8 0.8 0.01 15.2 0.8 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.22 EXF76943.1 - 0.0071 15.5 0.3 0.011 14.9 0.3 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A Trp_halogenase PF04820.14 EXF76943.1 - 0.0081 15.0 0.0 2.1 7.1 0.0 2.3 2 0 0 2 2 2 2 Tryptophan halogenase HI0933_like PF03486.14 EXF76943.1 - 0.0089 14.8 0.4 0.02 13.6 0.5 1.5 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox_3 PF13738.6 EXF76943.1 - 0.011 14.9 0.0 0.02 14.1 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EXF76943.1 - 0.016 14.4 0.2 0.032 13.5 0.2 1.4 1 0 0 1 1 1 0 Thi4 family SE PF08491.10 EXF76943.1 - 0.036 13.1 0.0 0.073 12.1 0.0 1.4 1 1 0 1 1 1 0 Squalene epoxidase Pyr_redox PF00070.27 EXF76943.1 - 0.038 14.5 0.7 0.088 13.4 0.7 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 EXF76943.1 - 0.039 13.2 0.6 0.069 12.4 0.6 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Amino_oxidase PF01593.24 EXF76943.1 - 0.089 12.1 0.1 1.6 7.9 0.0 2.3 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase Lycopene_cycl PF05834.12 EXF76943.1 - 0.12 11.4 0.2 1.9 7.4 0.2 2.0 2 0 0 2 2 2 0 Lycopene cyclase protein PC_rep PF01851.22 EXF76943.1 - 0.15 12.6 0.0 2.2 8.9 0.0 2.7 2 1 0 2 2 2 0 Proteasome/cyclosome repeat Rossmann-like PF10727.9 EXF76943.1 - 0.16 11.9 0.2 0.36 10.7 0.2 1.6 1 0 0 1 1 1 0 Rossmann-like domain FAD_binding_1 PF00667.20 EXF76944.1 - 2.4e-38 131.9 0.0 4e-38 131.2 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 EXF76944.1 - 1.1e-26 93.7 0.1 2.1e-26 92.9 0.1 1.5 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 EXF76944.1 - 1.3e-17 64.4 0.0 5.5e-17 62.4 0.0 2.1 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain p450 PF00067.22 EXF76945.1 - 9.3e-67 225.8 0.0 1.2e-66 225.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Sugar_tr PF00083.24 EXF76946.1 - 5.4e-109 365.1 18.1 6.3e-109 364.8 18.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF76946.1 - 6.7e-28 97.6 56.9 9e-18 64.3 27.0 2.6 1 1 2 3 3 3 3 Major Facilitator Superfamily TRI12 PF06609.13 EXF76946.1 - 1.6e-05 23.5 1.4 1.6e-05 23.5 1.4 1.6 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) UNC-93 PF05978.16 EXF76946.1 - 0.00018 21.3 3.6 0.00018 21.3 3.6 2.8 3 0 0 3 3 3 1 Ion channel regulatory protein UNC-93 PTR2 PF00854.21 EXF76946.1 - 0.0065 15.3 1.6 0.46 9.3 1.0 2.3 2 0 0 2 2 2 2 POT family DUF3464 PF11947.8 EXF76946.1 - 0.2 11.4 0.1 18 5.0 0.1 2.7 2 1 0 2 2 2 0 Photosynthesis affected mutant 68 DUF724 PF05266.14 EXF76947.1 - 0.58 10.0 1.8 1.2 8.9 1.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF724) Sugar_tr PF00083.24 EXF76948.1 - 5.6e-58 196.9 25.2 6.5e-58 196.7 25.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF76948.1 - 5.6e-16 58.4 45.9 8.8e-14 51.2 33.5 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Nuc_H_symport PF03825.16 EXF76948.1 - 0.00081 18.5 1.5 0.00081 18.5 1.5 2.3 2 0 0 2 2 2 1 Nucleoside H+ symporter MFS_1_like PF12832.7 EXF76948.1 - 0.1 11.4 10.6 0.0082 15.0 2.9 2.3 2 0 0 2 2 2 0 MFS_1 like family DUF4387 PF14330.6 EXF76949.1 - 1.6e-33 115.3 0.0 3.2e-33 114.3 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4387) AtuA PF07287.11 EXF76949.1 - 1e-11 44.2 0.0 1.8e-11 43.4 0.0 1.4 1 0 0 1 1 1 1 Acyclic terpene utilisation family protein AtuA Glyco_hydro_43 PF04616.14 EXF76950.1 - 4.9e-32 111.4 0.1 6.1e-32 111.1 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 p450 PF00067.22 EXF76951.1 - 1.2e-07 30.9 0.0 2.5e-06 26.5 0.0 2.0 1 1 0 1 1 1 1 Cytochrome P450 Aa_trans PF01490.18 EXF76952.1 - 6.4e-29 100.9 33.8 1.2e-28 100.0 33.8 1.4 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein SHR3_chaperone PF08229.11 EXF76952.1 - 0.035 13.1 4.7 1.9 7.4 0.1 3.3 3 1 0 3 3 3 0 ER membrane protein SH3 Abhydrolase_9_N PF15420.6 EXF76952.1 - 2.5 8.1 15.2 3.1 7.7 1.7 2.4 2 0 0 2 2 2 0 Alpha/beta-hydrolase family N-terminus Methyltransf_16 PF10294.9 EXF76953.1 - 3.7e-05 23.5 0.0 5.3e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 Lysine methyltransferase PrmA PF06325.13 EXF76953.1 - 0.0047 16.4 0.0 0.0071 15.8 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_23 PF13489.6 EXF76954.1 - 1.6e-16 60.6 0.0 2.7e-16 59.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF76954.1 - 8.1e-10 39.3 0.0 2.9e-09 37.5 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF76954.1 - 8.9e-09 35.9 0.0 2.1e-08 34.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF76954.1 - 5.8e-06 26.2 0.0 5.4e-05 23.0 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF76954.1 - 2.6e-05 24.9 0.0 0.00022 21.9 0.0 2.5 2 1 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 EXF76954.1 - 0.00068 19.0 0.0 0.0024 17.2 0.0 1.8 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_8 PF05148.15 EXF76954.1 - 0.056 13.3 0.0 1.5 8.6 0.0 2.3 2 0 0 2 2 2 0 Hypothetical methyltransferase Ribosomal_L22 PF00237.19 EXF76955.1 - 2.8e-41 139.9 0.0 4.1e-41 139.4 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e LTD PF00932.19 EXF76955.1 - 0.12 12.7 0.0 0.16 12.3 0.0 1.5 1 1 0 1 1 1 0 Lamin Tail Domain DUF3455 PF11937.8 EXF76957.1 - 4.6e-41 140.8 0.0 6.5e-41 140.3 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3455) DUF2990 PF11693.8 EXF76957.1 - 0.0019 18.3 4.5 0.033 14.3 2.9 2.9 2 1 0 2 2 2 1 Protein of unknown function (DUF2990) CASP_C PF08172.12 EXF76958.1 - 3.5e-95 318.1 13.3 3e-93 311.8 0.0 3.9 3 1 2 5 5 5 1 CASP C terminal XRCC4 PF06632.12 EXF76958.1 - 0.0013 17.6 7.3 0.0013 17.6 7.3 3.3 2 1 1 3 3 3 1 DNA double-strand break repair and V(D)J recombination protein XRCC4 TolA_bind_tri PF16331.5 EXF76958.1 - 0.0014 18.6 31.9 0.046 13.8 0.2 6.0 6 0 0 6 6 6 2 TolA binding protein trimerisation bZIP_2 PF07716.15 EXF76958.1 - 0.0053 16.8 1.4 0.0053 16.8 1.4 7.5 8 1 0 8 8 7 2 Basic region leucine zipper ADIP PF11559.8 EXF76958.1 - 0.0057 16.7 6.2 0.0057 16.7 6.2 6.7 4 2 2 7 7 7 2 Afadin- and alpha -actinin-Binding DUF4164 PF13747.6 EXF76958.1 - 0.009 16.3 1.2 0.009 16.3 1.2 5.8 5 1 0 5 5 5 1 Domain of unknown function (DUF4164) SlyX PF04102.12 EXF76958.1 - 0.015 15.9 0.0 0.015 15.9 0.0 6.8 7 1 0 7 7 7 0 SlyX Filament PF00038.21 EXF76958.1 - 0.024 14.2 46.2 0.27 10.8 3.7 3.9 3 1 2 5 5 5 0 Intermediate filament protein DUF4407 PF14362.6 EXF76958.1 - 0.045 13.1 29.6 3.2 7.0 0.0 4.3 2 1 2 4 4 4 0 Domain of unknown function (DUF4407) DUF2400 PF09674.10 EXF76958.1 - 0.077 13.0 3.0 0.49 10.3 0.2 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2400) CENP-H PF05837.12 EXF76958.1 - 0.12 12.8 0.2 0.12 12.8 0.2 5.9 5 1 1 6 6 6 0 Centromere protein H (CENP-H) DUF1664 PF07889.12 EXF76958.1 - 0.16 12.0 0.1 0.16 12.0 0.1 5.8 4 2 2 6 6 5 0 Protein of unknown function (DUF1664) PI3K_P85_iSH2 PF16454.5 EXF76958.1 - 0.29 10.7 35.9 0.05 13.2 3.9 4.9 3 1 1 5 5 5 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain GTP-bdg_M PF16360.5 EXF76958.1 - 0.35 11.5 0.0 0.35 11.5 0.0 5.4 4 1 1 5 5 5 0 GTP-binding GTPase Middle Region Metal_resist PF13801.6 EXF76958.1 - 0.47 10.6 0.0 0.47 10.6 0.0 3.5 4 0 0 4 4 3 0 Heavy-metal resistance YabA PF06156.13 EXF76958.1 - 0.74 10.5 35.0 1.7 9.3 0.0 6.1 3 2 2 6 6 6 0 Initiation control protein YabA IFP_35_N PF07334.13 EXF76958.1 - 0.96 9.6 0.0 0.96 9.6 0.0 4.7 5 1 0 5 5 4 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus Fez1 PF06818.15 EXF76958.1 - 1 9.8 45.5 2.6 8.5 3.3 4.7 3 1 2 5 5 5 0 Fez1 APG6_N PF17675.1 EXF76958.1 - 1.5 9.4 58.3 4.1 7.9 0.2 5.8 2 1 3 5 5 5 0 Apg6 coiled-coil region TPR_MLP1_2 PF07926.12 EXF76958.1 - 3 7.9 61.4 0.59 10.2 7.7 6.8 5 2 1 6 6 6 0 TPR/MLP1/MLP2-like protein WD40_alt PF14077.6 EXF76958.1 - 4 7.4 7.2 10 6.1 0.0 3.9 3 1 1 4 4 3 0 Alternative WD40 repeat motif FlaC_arch PF05377.11 EXF76958.1 - 4 7.9 34.4 0.47 10.9 0.2 7.1 6 1 1 7 7 7 0 Flagella accessory protein C (FlaC) SKA1 PF07160.12 EXF76958.1 - 7 6.4 25.5 11 5.8 0.0 4.5 3 1 1 4 4 4 0 Spindle and kinetochore-associated protein 1 Vps39_2 PF10367.9 EXF76959.1 - 2.2e-07 31.3 0.0 5.9e-07 29.9 0.0 1.7 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 Vps39_1 PF10366.9 EXF76959.1 - 0.018 15.3 0.0 0.074 13.3 0.0 2.0 2 0 0 2 2 2 0 Vacuolar sorting protein 39 domain 1 HEAT_EZ PF13513.6 EXF76960.1 - 6.8e-29 99.9 10.7 1.6e-14 54.0 0.0 11.3 12 1 0 12 12 12 3 HEAT-like repeat HEAT PF02985.22 EXF76960.1 - 5.3e-28 94.7 6.6 4.6e-05 23.3 0.0 10.6 11 0 0 11 11 11 6 HEAT repeat HEAT_2 PF13646.6 EXF76960.1 - 6.5e-20 71.3 1.4 0.0027 18.1 0.0 8.1 4 3 4 8 8 8 4 HEAT repeats Cnd1 PF12717.7 EXF76960.1 - 8.2e-12 45.5 0.3 0.005 16.9 0.0 5.4 4 1 0 4 4 4 2 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 EXF76960.1 - 1.5e-10 41.5 0.0 0.0015 19.1 0.0 6.1 5 2 1 6 6 5 1 Vacuolar 14 Fab1-binding region MMS19_C PF12460.8 EXF76960.1 - 3e-08 33.2 2.6 0.39 9.8 0.0 5.1 5 0 0 5 5 5 3 RNAPII transcription regulator C-terminal IBN_N PF03810.19 EXF76960.1 - 1.8e-07 31.0 0.9 6.9e-06 25.9 0.0 4.3 4 1 0 4 4 4 1 Importin-beta N-terminal domain CLASP_N PF12348.8 EXF76960.1 - 2e-07 30.8 0.1 1.1 8.7 0.0 6.5 5 2 0 6 6 6 1 CLASP N terminal Adaptin_N PF01602.20 EXF76960.1 - 8.9e-05 21.2 0.3 0.54 8.7 0.1 3.4 2 2 0 2 2 2 2 Adaptin N terminal region HEAT_PBS PF03130.16 EXF76960.1 - 0.00053 20.4 5.1 21 6.1 0.0 6.0 6 0 0 6 6 4 0 PBS lyase HEAT-like repeat Arm PF00514.23 EXF76960.1 - 0.0013 18.7 3.9 7.9 6.7 0.0 5.9 5 1 1 6 6 6 2 Armadillo/beta-catenin-like repeat RTP1_C1 PF10363.9 EXF76960.1 - 0.0033 17.6 0.2 0.15 12.2 0.0 3.6 4 0 0 4 4 4 1 Required for nuclear transport of RNA pol II C-terminus 1 Gcn1_N PF12074.8 EXF76960.1 - 0.0063 15.8 0.1 3.3 6.9 0.0 3.3 3 0 0 3 3 3 1 Generalcontrol nonderepressible 1 (Gcn1) N-terminal DUF3437 PF11919.8 EXF76960.1 - 0.0088 15.9 0.1 6.8 6.7 0.0 4.1 3 0 0 3 3 3 1 Domain of unknown function (DUF3437) Glyco_hydro_10 PF00331.20 EXF76960.1 - 0.03 13.5 0.0 0.058 12.5 0.0 1.5 1 0 0 1 1 1 0 Glycosyl hydrolase family 10 BP28CT PF08146.12 EXF76960.1 - 0.066 13.1 0.0 0.76 9.6 0.0 2.8 3 0 0 3 3 3 0 BP28CT (NUC211) domain PAC4 PF16093.5 EXF76961.1 - 5.4e-21 74.6 0.1 7.4e-21 74.1 0.1 1.2 1 0 0 1 1 1 1 Proteasome assembly chaperone 4 POC3_POC4 PF10448.9 EXF76961.1 - 0.099 12.7 0.0 0.13 12.3 0.0 1.3 1 1 0 1 1 1 0 20S proteasome chaperone assembly proteins 3 and 4 GCD14 PF08704.10 EXF76962.1 - 0.059 13.0 0.0 3.1 7.4 0.0 2.4 2 0 0 2 2 2 0 tRNA methyltransferase complex GCD14 subunit DUF4178 PF13785.6 EXF76964.1 - 0.0079 16.3 0.5 0.038 14.1 0.7 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4178) Peptidase_C12 PF01088.21 EXF76966.1 - 1.4e-67 227.6 0.0 1.7e-67 227.2 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 UCH_C PF18031.1 EXF76966.1 - 3.8e-11 42.7 0.2 8.1e-11 41.6 0.2 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolases Xan_ur_permease PF00860.20 EXF76967.1 - 2.5e-26 92.3 25.7 3.4e-25 88.6 23.3 3.0 2 1 0 2 2 2 1 Permease family MFS_MOT1 PF16983.5 EXF76967.1 - 0.0013 19.1 2.5 0.0013 19.1 2.5 3.3 4 0 0 4 4 4 2 Molybdate transporter of MFS superfamily SPC25 PF06703.11 EXF76967.1 - 0.72 9.6 3.2 2.2 8.0 0.3 2.5 2 0 0 2 2 2 0 Microsomal signal peptidase 25 kDa subunit (SPC25) SCIMP PF15050.6 EXF76969.1 - 0.064 13.7 0.0 0.076 13.5 0.0 1.1 1 0 0 1 1 1 0 SCIMP protein 7tm_2 PF00002.24 EXF76970.1 - 1.9e-12 47.0 4.9 1.9e-12 47.0 4.9 1.6 2 0 0 2 2 2 1 7 transmembrane receptor (Secretin family) Dicty_CAR PF05462.11 EXF76970.1 - 6.5e-11 41.9 4.5 6.5e-11 41.9 4.5 1.9 2 0 0 2 2 2 1 Slime mold cyclic AMP receptor 7tm_1 PF00001.21 EXF76970.1 - 7.3e-07 28.8 3.2 1e-06 28.3 3.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Git3 PF11710.8 EXF76970.1 - 2.6e-06 27.4 7.1 5.7e-06 26.3 7.1 1.6 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 7TM_GPCR_Srsx PF10320.9 EXF76970.1 - 0.0038 16.7 2.9 0.0038 16.7 2.9 1.8 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx STE3 PF02076.15 EXF76970.1 - 0.0051 16.1 4.6 0.0051 16.1 4.6 2.7 2 2 1 3 3 3 1 Pheromone A receptor Frizzled PF01534.17 EXF76970.1 - 0.021 13.9 12.5 0.23 10.5 9.5 2.4 2 1 0 2 2 2 0 Frizzled/Smoothened family membrane region TMEMspv1-c74-12 PF11044.8 EXF76970.1 - 0.12 12.4 0.2 0.28 11.2 0.2 1.5 1 0 0 1 1 1 0 Plectrovirus spv1-c74 ORF 12 transmembrane protein Fibrillarin PF01269.17 EXF76972.1 - 1.1e-101 338.7 0.0 1.3e-101 338.4 0.0 1.0 1 0 0 1 1 1 1 Fibrillarin GCD14 PF08704.10 EXF76972.1 - 0.00017 21.4 0.0 0.00035 20.3 0.0 1.4 1 1 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit TPT PF03151.16 EXF76974.1 - 9.7e-35 120.3 16.2 1.2e-34 120.0 16.2 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family UAA PF08449.11 EXF76974.1 - 0.00087 18.6 18.5 0.0022 17.3 18.5 1.8 1 1 0 1 1 1 1 UAA transporter family EamA PF00892.20 EXF76974.1 - 0.026 14.7 33.8 0.38 10.9 13.9 2.5 2 1 0 2 2 2 0 EamA-like transporter family BTP PF05232.12 EXF76974.1 - 0.31 11.1 5.6 15 5.8 0.0 3.5 3 0 0 3 3 3 0 Chlorhexidine efflux transporter APH PF01636.23 EXF76975.1 - 3.9e-05 23.7 0.1 0.00019 21.4 0.0 2.1 2 0 0 2 2 2 1 Phosphotransferase enzyme family Steroid_dh PF02544.16 EXF76976.1 - 1.1e-15 57.9 0.9 2.4e-15 56.8 0.9 1.6 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.12 EXF76976.1 - 0.00028 20.5 0.8 0.00069 19.2 0.8 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) PEMT PF04191.13 EXF76976.1 - 0.031 14.7 1.5 0.08 13.3 0.1 2.4 2 0 0 2 2 2 0 Phospholipid methyltransferase DUF2085 PF09858.9 EXF76976.1 - 0.2 12.1 2.9 0.36 11.3 0.1 2.8 2 1 2 4 4 4 0 Predicted membrane protein (DUF2085) 2OG-FeII_Oxy_2 PF13532.6 EXF76977.1 - 0.0018 18.5 0.1 0.067 13.4 0.1 2.8 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Ank_2 PF12796.7 EXF76978.1 - 5.8e-21 74.9 0.0 4.8e-13 49.5 0.1 2.6 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EXF76978.1 - 4.5e-14 52.6 0.0 3e-07 30.8 0.0 4.7 2 2 4 6 6 6 5 Ankyrin repeats (many copies) Ank PF00023.30 EXF76978.1 - 4.4e-12 45.9 2.7 0.00017 21.9 0.1 4.5 4 0 0 4 4 4 3 Ankyrin repeat Ank_3 PF13606.6 EXF76978.1 - 3.1e-10 39.4 0.5 0.0027 18.0 0.1 5.3 5 0 0 5 5 5 2 Ankyrin repeat Ank_5 PF13857.6 EXF76978.1 - 1.8e-08 34.5 2.5 0.00065 19.9 0.4 3.3 3 1 2 5 5 5 3 Ankyrin repeats (many copies) MMR_HSR1_Xtn PF16897.5 EXF76979.1 - 3.3e-37 126.7 0.8 5.9e-37 125.9 0.8 1.4 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain MMR_HSR1 PF01926.23 EXF76979.1 - 5.1e-21 74.9 0.1 3.2e-20 72.3 0.0 2.1 1 1 1 2 2 2 1 50S ribosome-binding GTPase TGS PF02824.21 EXF76979.1 - 8.3e-17 61.0 0.0 2.1e-16 59.7 0.0 1.7 1 0 0 1 1 1 1 TGS domain FeoB_N PF02421.18 EXF76979.1 - 8.8e-10 38.3 0.1 4.9e-09 35.9 0.0 2.1 2 0 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EXF76979.1 - 0.00018 21.6 0.1 0.056 13.5 0.0 2.5 1 1 1 2 2 2 1 Dynamin family MeaB PF03308.16 EXF76979.1 - 0.00046 19.2 0.3 0.028 13.4 0.1 2.2 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB GTP_EFTU PF00009.27 EXF76979.1 - 0.001 18.7 0.4 4.9 6.6 0.0 3.9 2 2 1 3 3 3 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EXF76979.1 - 0.02 14.8 0.5 5.8 6.8 0.1 3.1 2 1 0 3 3 3 0 RsgA GTPase AIG1 PF04548.16 EXF76979.1 - 0.022 14.1 0.0 0.037 13.3 0.0 1.3 1 0 0 1 1 1 0 AIG1 family Arf PF00025.21 EXF76979.1 - 0.073 12.5 0.3 13 5.2 0.0 2.3 2 0 0 2 2 2 0 ADP-ribosylation factor family Roc PF08477.13 EXF76979.1 - 0.13 12.5 0.1 5.7 7.2 0.0 2.5 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_22 PF13401.6 EXF76979.1 - 0.15 12.3 0.1 1.3 9.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain HTH_Tnp_Tc5 PF03221.16 EXF76980.1 - 4.8e-11 42.5 0.1 1.6e-10 40.9 0.0 1.9 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain CENP-B_N PF04218.13 EXF76980.1 - 7e-06 25.6 0.0 1.2e-05 24.8 0.0 1.3 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain MarR PF01047.22 EXF76980.1 - 0.00077 19.3 0.1 0.03 14.2 0.0 2.6 2 0 0 2 2 2 1 MarR family HTH_Crp_2 PF13545.6 EXF76980.1 - 0.01 15.8 0.0 0.035 14.1 0.0 1.9 2 0 0 2 2 2 0 Crp-like helix-turn-helix domain HTH_Tnp_4 PF13613.6 EXF76980.1 - 0.012 15.3 0.0 0.023 14.4 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix of DDE superfamily endonuclease HTH_23 PF13384.6 EXF76980.1 - 0.18 11.7 0.0 0.78 9.6 0.0 2.0 2 0 0 2 2 2 0 Homeodomain-like domain PXA PF02194.15 EXF76981.1 - 2e-47 161.6 0.3 2.2e-46 158.1 0.9 2.2 2 0 0 2 2 2 1 PXA domain Nexin_C PF08628.12 EXF76981.1 - 0.0015 19.1 0.0 0.0061 17.1 0.0 2.0 1 0 0 1 1 1 1 Sorting nexin C terminal zf-Mss51 PF13824.6 EXF76982.1 - 3.1e-28 97.6 6.5 5.9e-28 96.7 6.5 1.5 1 0 0 1 1 1 1 Zinc-finger of mitochondrial splicing suppressor 51 MMS1_N PF10433.9 EXF76983.1 - 3e-159 530.8 0.0 6.1e-159 529.8 0.0 1.5 2 0 0 2 2 2 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 EXF76983.1 - 6.2e-101 337.9 0.0 2.5e-100 335.9 0.0 2.0 2 0 0 2 2 2 1 CPSF A subunit region ANAPC4_WD40 PF12894.7 EXF76983.1 - 0.16 12.3 0.0 4.5 7.6 0.0 3.2 3 1 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain UBA_4 PF14555.6 EXF76984.1 - 0.0064 16.3 0.0 0.012 15.4 0.0 1.4 1 0 0 1 1 1 1 UBA-like domain LysM PF01476.20 EXF76984.1 - 0.013 15.6 0.0 0.021 14.9 0.0 1.3 1 0 0 1 1 1 0 LysM domain DZR PF12773.7 EXF76984.1 - 0.031 14.3 1.6 0.031 14.3 1.6 2.0 1 1 1 2 2 2 0 Double zinc ribbon zf-RING_6 PF14835.6 EXF76984.1 - 0.032 14.1 1.4 0.069 13.0 1.4 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein Prok-RING_4 PF14447.6 EXF76984.1 - 0.22 11.4 10.0 0.48 10.3 10.1 1.5 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 Nicastrin PF05450.15 EXF76986.1 - 1.6 8.1 4.4 3.4 7.1 4.4 1.4 1 0 0 1 1 1 0 Nicastrin Spt20 PF12090.8 EXF76986.1 - 3 7.4 15.7 4.8 6.7 15.7 1.2 1 0 0 1 1 1 0 Spt20 family TFIIA PF03153.13 EXF76986.1 - 6.5 6.6 18.3 0.84 9.6 14.1 1.5 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Glyco_hydro_43 PF04616.14 EXF76987.1 - 6.6e-36 124.1 0.9 8e-36 123.8 0.9 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 LRR_10 PF18805.1 EXF76987.1 - 0.028 14.0 0.3 0.11 12.2 0.2 2.0 2 0 0 2 2 2 0 Leucine-rich repeat Fungal_trans PF04082.18 EXF76990.1 - 1e-19 70.6 0.0 2.3e-19 69.5 0.0 1.6 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF76990.1 - 7.1e-08 32.5 9.1 1.7e-07 31.3 9.1 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Siva PF05458.12 EXF76990.1 - 0.76 9.4 9.6 0.83 9.3 0.0 2.4 2 0 0 2 2 2 0 Cd27 binding protein (Siva) GPR15L PF15854.5 EXF76990.1 - 2.2 8.6 8.6 9.3 6.6 4.0 2.5 2 0 0 2 2 2 0 G-protein coupled receptor ligand 15 Sugar_tr PF00083.24 EXF76991.1 - 2e-109 366.5 22.7 2.2e-109 366.3 22.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF76991.1 - 1.7e-25 89.7 44.5 4.7e-20 71.8 13.2 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF3980 PF13140.6 EXF76991.1 - 1.1 9.7 5.6 36 4.9 0.3 3.8 2 1 1 3 3 3 0 Domain of unknown function (DUF3980) Fungal_trans_2 PF11951.8 EXF76992.1 - 1.8e-21 76.4 0.0 2.3e-21 76.1 0.0 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain DHDPS PF00701.22 EXF76993.1 - 3.9e-42 143.9 0.0 4.9e-42 143.6 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family ROKNT PF08067.11 EXF76994.1 - 3.1 8.2 18.6 8.9 6.7 2.6 6.2 1 1 2 3 3 3 0 ROKNT (NUC014) domain DUF3328 PF11807.8 EXF76995.1 - 1.8e-40 139.0 3.9 3.9e-29 102.0 0.2 2.1 2 0 0 2 2 2 2 Domain of unknown function (DUF3328) IFP_35_N PF07334.13 EXF76996.1 - 0.04 14.0 1.0 0.091 12.8 1.0 1.5 1 0 0 1 1 1 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus SET PF00856.28 EXF76997.1 - 1.5e-12 48.3 0.0 5.2e-12 46.5 0.0 1.9 1 1 0 1 1 1 1 SET domain HET PF06985.11 EXF76998.1 - 1.3e-28 100.2 0.2 3.8e-28 98.7 0.2 1.9 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Sugar_tr PF00083.24 EXF76999.1 - 1.5e-99 333.9 30.5 1.9e-99 333.6 30.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF76999.1 - 6.7e-22 77.9 33.1 6.7e-22 77.9 33.1 2.2 1 1 0 1 1 1 1 Major Facilitator Superfamily AA_permease PF00324.21 EXF77000.1 - 1.7e-101 340.2 44.2 2.1e-101 339.9 44.2 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EXF77000.1 - 1.9e-27 96.2 45.3 2.2e-27 96.0 45.3 1.1 1 0 0 1 1 1 1 Amino acid permease PNP_UDP_1 PF01048.20 EXF77001.1 - 3.6e-09 36.2 0.0 1.3e-08 34.4 0.0 1.9 1 1 0 1 1 1 1 Phosphorylase superfamily NACHT PF05729.12 EXF77001.1 - 9.1e-09 35.4 0.0 1.9e-08 34.4 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 EXF77001.1 - 4.4e-07 30.5 0.3 8.6e-07 29.5 0.3 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 EXF77001.1 - 0.018 15.5 2.4 0.079 13.4 0.1 3.1 3 2 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) APS_kinase PF01583.20 EXF77001.1 - 0.073 13.0 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_30 PF13604.6 EXF77001.1 - 0.091 12.5 0.0 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EXF77001.1 - 0.1 12.9 0.0 0.2 11.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EXF77001.1 - 0.14 12.5 0.0 0.6 10.5 0.0 2.1 1 0 0 1 1 1 0 RNA helicase RL PF17797.1 EXF77002.1 - 0.26 11.3 0.5 0.67 10.0 0.0 1.8 2 0 0 2 2 2 0 RL domain DUF4658 PF15555.6 EXF77003.1 - 0.024 14.8 0.0 0.04 14.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4658) DUF1180 PF06679.12 EXF77003.1 - 0.1 13.0 0.0 0.18 12.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) LDB19 PF13002.7 EXF77004.1 - 1.8e-34 119.1 0.4 3e-34 118.4 0.4 1.2 1 0 0 1 1 1 1 Arrestin_N terminal like Arrestin_N PF00339.29 EXF77004.1 - 2.4e-05 24.5 0.0 5.7e-05 23.2 0.0 1.7 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain p450 PF00067.22 EXF77005.1 - 1.7e-24 86.4 0.0 1.9e-24 86.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 DUF2201 PF09967.9 EXF77006.1 - 0.13 12.5 0.1 0.7 10.0 0.0 2.0 1 1 1 2 2 2 0 VWA-like domain (DUF2201) Glyco_hydro_16 PF00722.21 EXF77007.1 - 1.3e-12 47.6 0.1 1.8e-12 47.1 0.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 SKN1 PF03935.15 EXF77007.1 - 2.3e-06 26.3 0.5 0.0057 15.1 0.0 2.1 2 0 0 2 2 2 2 Beta-glucan synthesis-associated protein (SKN1) MFS_1 PF07690.16 EXF77009.1 - 1.1e-28 100.2 28.2 1.5e-28 99.7 28.2 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF3487 PF11990.8 EXF77009.1 - 0.92 9.4 5.3 0.65 9.9 0.3 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3487) Ribonuc_L-PSP PF01042.21 EXF77010.1 - 2.2e-16 60.0 0.0 2.9e-16 59.6 0.0 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP DNA_pol_phi PF04931.13 EXF77011.1 - 0.14 10.2 0.2 0.25 9.4 0.2 1.3 1 0 0 1 1 1 0 DNA polymerase phi Pectate_lyase PF03211.13 EXF77013.1 - 2.3e-87 291.8 5.4 3.1e-87 291.4 5.4 1.1 1 0 0 1 1 1 1 Pectate lyase FAM176 PF14851.6 EXF77014.1 - 0.21 11.2 0.5 0.33 10.6 0.5 1.2 1 0 0 1 1 1 0 FAM176 family NmrA PF05368.13 EXF77015.1 - 3.8e-13 49.5 0.0 4.8e-13 49.2 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family TPR_12 PF13424.6 EXF77016.1 - 1.1e-13 51.2 23.3 9.8e-07 29.0 0.1 7.2 6 1 1 7 7 7 3 Tetratricopeptide repeat TPR_10 PF13374.6 EXF77016.1 - 1.4e-10 40.7 14.2 0.0027 17.5 0.9 7.4 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_2 PF07719.17 EXF77016.1 - 5.9e-05 22.9 30.6 2.6 8.4 1.1 8.3 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_14 PF13428.6 EXF77016.1 - 0.00068 20.3 22.3 6.4 7.9 0.1 8.4 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_8 PF13181.6 EXF77016.1 - 0.02 15.1 10.5 4.8 7.6 0.2 5.4 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_16 PF13432.6 EXF77016.1 - 0.064 13.9 13.5 1.3 9.8 0.1 6.2 6 2 0 6 6 6 0 Tetratricopeptide repeat TPR_1 PF00515.28 EXF77016.1 - 0.065 13.1 21.0 3 7.8 0.3 7.3 9 0 0 9 9 9 0 Tetratricopeptide repeat TPR_5 PF12688.7 EXF77016.1 - 0.17 12.1 4.0 0.32 11.2 0.1 3.3 4 1 1 5 5 5 0 Tetratrico peptide repeat TPR_6 PF13174.6 EXF77016.1 - 0.23 12.1 12.8 1.9 9.3 1.5 6.0 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_7 PF13176.6 EXF77016.1 - 6.8 7.0 20.9 14 6.0 0.5 7.7 8 0 0 8 8 8 0 Tetratricopeptide repeat ABC2_membrane PF01061.24 EXF77017.1 - 1e-81 273.3 60.7 1.6e-44 151.9 21.9 3.4 4 0 0 4 4 4 2 ABC-2 type transporter PDR_CDR PF06422.12 EXF77017.1 - 1.4e-41 140.3 1.2 3e-34 116.8 0.0 3.4 2 0 0 2 2 2 2 CDR ABC transporter ABC_tran PF00005.27 EXF77017.1 - 5.4e-38 130.6 0.0 2.6e-17 63.6 0.0 3.4 4 0 0 4 4 3 2 ABC transporter ABC_trans_N PF14510.6 EXF77017.1 - 3.1e-17 62.9 0.0 7.9e-17 61.6 0.0 1.7 1 0 0 1 1 1 1 ABC-transporter N-terminal AAA_16 PF13191.6 EXF77017.1 - 1.8e-07 31.7 0.1 0.008 16.6 0.0 3.0 3 0 0 3 3 3 2 AAA ATPase domain AAA_18 PF13238.6 EXF77017.1 - 3.4e-06 27.6 0.0 0.00033 21.2 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 EXF77017.1 - 3.5e-06 26.7 0.2 5e-05 23.0 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EXF77017.1 - 9.6e-06 25.8 0.1 0.013 15.6 0.0 2.8 3 0 0 3 3 3 2 AAA domain RsgA_GTPase PF03193.16 EXF77017.1 - 1e-05 25.5 0.1 0.0029 17.5 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_29 PF13555.6 EXF77017.1 - 9.9e-05 22.0 0.8 0.03 14.0 0.1 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain ABC2_membrane_3 PF12698.7 EXF77017.1 - 0.00049 19.3 45.2 0.0026 17.0 15.0 2.9 2 1 1 3 3 3 2 ABC-2 family transporter protein SMC_N PF02463.19 EXF77017.1 - 0.00075 19.0 0.0 0.22 11.0 0.0 3.6 3 1 0 3 3 3 1 RecF/RecN/SMC N terminal domain AAA_17 PF13207.6 EXF77017.1 - 0.0013 19.1 0.3 0.34 11.3 0.0 2.9 2 1 0 2 2 2 1 AAA domain AAA_21 PF13304.6 EXF77017.1 - 0.0039 17.1 0.1 1.6 8.5 0.0 2.8 3 0 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 EXF77017.1 - 0.0059 16.9 0.4 3 8.1 0.1 3.1 3 0 0 3 3 3 1 AAA domain AAA_30 PF13604.6 EXF77017.1 - 0.023 14.4 0.8 2.3 7.9 0.2 2.5 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 EXF77017.1 - 0.024 14.5 0.7 2.6 8.0 0.2 2.7 2 0 0 2 2 2 0 NACHT domain cobW PF02492.19 EXF77017.1 - 0.027 14.0 0.9 0.72 9.4 0.1 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA PF00004.29 EXF77017.1 - 0.043 14.2 0.0 16 5.9 0.0 2.8 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 EXF77017.1 - 0.25 11.6 0.8 10 6.3 0.2 2.7 2 0 0 2 2 2 0 AAA domain p450 PF00067.22 EXF77019.1 - 1.9e-65 221.5 0.0 3.1e-65 220.7 0.0 1.3 1 0 0 1 1 1 1 Cytochrome P450 WG_beta_rep PF14903.6 EXF77019.1 - 0.017 15.4 0.1 0.04 14.2 0.1 1.6 1 0 0 1 1 1 0 WG containing repeat Pur_ac_phosph_N PF16656.5 EXF77020.1 - 0.84 10.3 6.3 0.37 11.4 0.2 2.9 2 1 0 2 2 2 0 Purple acid Phosphatase, N-terminal domain GPI-anchored PF10342.9 EXF77020.1 - 1.8 9.4 5.8 1.3 9.8 0.2 3.1 3 0 0 3 3 3 0 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family CLZ PF16526.5 EXF77022.1 - 0.082 13.3 0.0 0.13 12.6 0.0 1.3 1 0 0 1 1 1 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels HMG_box PF00505.19 EXF77023.1 - 5.9e-17 61.8 0.1 1.5e-16 60.6 0.1 1.7 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EXF77023.1 - 3.4e-11 43.6 1.5 3.5e-11 43.5 0.1 1.8 2 0 0 2 2 2 1 HMG-box domain SAM_1 PF00536.30 EXF77023.1 - 4e-11 43.2 0.0 6.7e-11 42.5 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 EXF77023.1 - 1.5e-08 34.6 0.0 2.9e-08 33.7 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) WYL_3 PF18488.1 EXF77023.1 - 0.33 11.4 2.6 0.84 10.0 2.6 1.7 1 0 0 1 1 1 0 WYL domain SH3_1 PF00018.28 EXF77025.1 - 1.1e-09 37.8 0.0 1.8e-09 37.0 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EXF77025.1 - 7e-08 32.2 0.1 1.4e-07 31.2 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EXF77025.1 - 9.8e-06 25.2 0.0 4.5e-05 23.0 0.0 2.1 2 0 0 2 2 2 1 Variant SH3 domain NAD_binding_1 PF00175.21 EXF77026.1 - 1.7e-32 112.3 0.0 3.4e-32 111.3 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 EXF77026.1 - 1.3e-22 79.9 0.0 2.3e-22 79.2 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 EXF77026.1 - 3e-09 37.2 0.0 0.00013 22.2 0.0 2.3 2 0 0 2 2 2 2 Ferric reductase NAD binding domain FAD_binding_9 PF08021.11 EXF77026.1 - 0.072 13.3 0.0 0.13 12.5 0.0 1.4 1 0 0 1 1 1 0 Siderophore-interacting FAD-binding domain TFR_dimer PF04253.15 EXF77027.1 - 4.8e-27 94.5 0.0 9e-27 93.6 0.0 1.5 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.17 EXF77027.1 - 2.6e-19 69.7 0.0 4.1e-19 69.1 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 EXF77027.1 - 6.3e-10 39.0 0.8 4.2e-09 36.3 0.1 2.3 2 0 0 2 2 2 1 PA domain MFS_1 PF07690.16 EXF77028.1 - 3.3e-39 134.8 27.1 3.7e-27 95.2 4.6 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EXF77028.1 - 0.0007 18.1 0.2 0.0007 18.1 0.2 1.5 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) IMPDH PF00478.25 EXF77029.1 - 6.7e-127 423.2 2.4 7.8e-127 423.0 2.4 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain CBS PF00571.28 EXF77029.1 - 3.3e-14 53.1 0.2 2.9e-06 27.6 0.1 2.5 2 0 0 2 2 2 2 CBS domain FMN_dh PF01070.18 EXF77029.1 - 4.2e-09 35.9 0.4 8.8e-07 28.3 0.5 2.3 2 0 0 2 2 2 2 FMN-dependent dehydrogenase NMO PF03060.15 EXF77029.1 - 4.8e-09 36.0 2.0 0.0017 17.8 1.5 2.3 2 0 0 2 2 2 2 Nitronate monooxygenase His_biosynth PF00977.21 EXF77029.1 - 0.0001 21.8 3.3 0.016 14.7 0.2 3.0 3 1 1 4 4 4 2 Histidine biosynthesis protein YpsA PF06908.11 EXF77029.1 - 0.034 14.1 0.2 0.076 13.0 0.0 1.6 2 0 0 2 2 2 0 YspA SLOG family ThiG PF05690.14 EXF77029.1 - 0.036 13.4 1.0 0.12 11.6 0.2 2.1 1 1 2 3 3 3 0 Thiazole biosynthesis protein ThiG RasGAP PF00616.19 EXF77030.1 - 5.3e-52 176.5 0.0 1.4e-51 175.2 0.0 1.8 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase RasGAP_C PF03836.15 EXF77030.1 - 6.9e-50 168.7 3.2 3.3e-49 166.5 3.2 2.3 1 0 0 1 1 1 1 RasGAP C-terminus IQ PF00612.27 EXF77030.1 - 9.5e-18 62.3 31.4 0.0018 17.9 0.1 14.2 15 0 0 15 15 15 6 IQ calmodulin-binding motif CH PF00307.31 EXF77030.1 - 5.6e-11 42.6 0.0 2.1e-10 40.7 0.0 2.0 1 0 0 1 1 1 1 Calponin homology (CH) domain Trimer_CC PF08954.11 EXF77030.1 - 0.083 12.5 4.2 0.13 11.9 1.5 2.9 2 0 0 2 2 2 0 Trimerisation motif DUF29 PF01724.16 EXF77030.1 - 0.69 10.1 6.7 0.62 10.3 0.2 3.0 2 0 0 2 2 2 0 Domain of unknown function DUF29 Sulfatase PF00884.23 EXF77031.1 - 1.7e-56 191.9 0.0 2.2e-56 191.5 0.0 1.1 1 0 0 1 1 1 1 Sulfatase Choline_sulf_C PF12411.8 EXF77031.1 - 2.9e-26 91.0 1.6 2.9e-26 91.0 1.6 2.5 3 0 0 3 3 3 1 Choline sulfatase enzyme C terminal Phosphodiest PF01663.22 EXF77031.1 - 2.8e-09 37.0 0.0 0.0013 18.4 0.0 2.3 2 0 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase DUF4976 PF16347.5 EXF77031.1 - 0.0019 18.4 0.0 0.0038 17.5 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4976) DUF229 PF02995.17 EXF77031.1 - 0.11 11.1 0.0 0.15 10.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF229) DUF4994 PF16385.5 EXF77031.1 - 0.13 12.1 0.0 15 5.6 0.0 2.3 1 1 1 2 2 2 0 Domain of unknown function Med8 PF10232.9 EXF77032.1 - 1.8e-34 119.3 0.0 2.3e-34 119.0 0.0 1.1 1 0 0 1 1 1 1 Mediator of RNA polymerase II transcription complex subunit 8 GEN1_C PF18380.1 EXF77032.1 - 0.027 15.4 0.3 0.046 14.6 0.3 1.4 1 0 0 1 1 1 0 Holliday junction resolvase Gen1 C-terminal domain Nop14 PF04147.12 EXF77032.1 - 1.2 7.2 5.3 1.3 7.1 3.6 1.7 2 0 0 2 2 2 0 Nop14-like family NOA36 PF06524.12 EXF77032.1 - 2 7.7 4.9 2.7 7.3 4.9 1.1 1 0 0 1 1 1 0 NOA36 protein HET PF06985.11 EXF77033.1 - 2.5e-25 89.5 0.0 3.8e-25 88.9 0.0 1.3 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) UTRA PF07702.13 EXF77033.1 - 0.14 12.0 0.0 0.25 11.2 0.0 1.3 1 0 0 1 1 1 0 UTRA domain DUF4188 PF13826.6 EXF77034.1 - 6.8e-34 116.7 0.1 9.9e-34 116.2 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4188) Dehydratase_hem PF13816.6 EXF77034.1 - 0.0077 15.7 0.0 0.014 14.9 0.0 1.4 1 1 0 1 1 1 1 Haem-containing dehydratase MFS_1 PF07690.16 EXF77035.1 - 1.4e-29 103.2 24.6 6e-25 87.9 5.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily BLUF PF04940.12 EXF77035.1 - 0.11 12.6 0.0 0.22 11.7 0.0 1.4 1 0 0 1 1 1 0 Sensors of blue-light using FAD 2OG-FeII_Oxy PF03171.20 EXF77036.1 - 2.6e-13 50.3 0.0 5.5e-13 49.3 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 EXF77036.1 - 6.7e-11 43.0 0.0 2.3e-10 41.3 0.0 1.8 2 0 0 2 2 2 1 non-haem dioxygenase in morphine synthesis N-terminal NAD_binding_2 PF03446.15 EXF77037.1 - 1.7e-25 90.0 0.9 2.8e-25 89.3 0.9 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 EXF77037.1 - 6.4e-09 36.1 0.0 1.4e-08 35.0 0.0 1.6 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase Shikimate_DH PF01488.20 EXF77037.1 - 8.3e-06 25.9 0.0 1.4e-05 25.2 0.0 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.17 EXF77037.1 - 4.3e-05 24.0 0.1 0.00029 21.4 0.0 2.2 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.19 EXF77037.1 - 0.02 14.2 0.0 0.035 13.5 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Fungal_trans PF04082.18 EXF77038.1 - 1.5e-22 79.9 0.4 2.3e-22 79.3 0.4 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain GST_C PF00043.25 EXF77038.1 - 2.3e-12 47.0 0.1 1e-11 44.9 0.0 2.1 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EXF77038.1 - 5.4e-09 36.0 0.7 1.4e-08 34.6 0.1 2.1 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EXF77038.1 - 4.2e-07 30.1 0.0 1.5e-06 28.3 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EXF77038.1 - 3e-06 27.5 0.0 6.5e-06 26.4 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EXF77038.1 - 0.0071 16.7 0.0 0.022 15.2 0.0 1.9 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain DIOX_N PF14226.6 EXF77039.1 - 8.2e-14 52.4 0.0 2.4e-13 50.8 0.0 1.7 2 0 0 2 2 2 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EXF77039.1 - 1.2e-08 35.4 0.0 2.7e-08 34.2 0.0 1.7 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Fungal_trans PF04082.18 EXF77040.1 - 0.0043 16.1 0.0 0.0078 15.3 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain PhyH PF05721.13 EXF77041.1 - 3.5e-13 50.3 0.0 6e-13 49.5 0.0 1.4 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) Sugar_tr PF00083.24 EXF77042.1 - 3e-111 372.5 26.6 3.7e-111 372.2 26.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF77042.1 - 1.1e-15 57.4 31.2 1.1e-15 57.4 31.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily GST_C_3 PF14497.6 EXF77043.1 - 3.5e-08 33.5 0.0 6.6e-08 32.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EXF77043.1 - 1.5e-06 28.4 0.0 1.4e-05 25.3 0.0 2.4 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EXF77043.1 - 1.4e-05 25.3 0.0 0.00016 21.9 0.0 2.1 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EXF77043.1 - 1.8e-05 24.8 0.0 5.2e-05 23.4 0.0 1.7 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EXF77043.1 - 1.9e-05 25.0 0.0 4.2e-05 23.9 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EXF77043.1 - 0.015 15.3 0.0 0.037 14.0 0.0 1.7 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Glyco_transf_20 PF00982.21 EXF77045.1 - 1.8e-145 485.3 0.0 2.7e-145 484.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 EXF77045.1 - 3.1e-70 236.0 0.0 5.4e-70 235.2 0.0 1.4 1 0 0 1 1 1 1 Trehalose-phosphatase Peptidase_S8 PF00082.22 EXF77046.1 - 1.4e-42 146.0 2.6 2.2e-42 145.4 2.6 1.3 1 0 0 1 1 1 1 Subtilase family fn3_5 PF06280.12 EXF77046.1 - 0.0046 17.6 0.0 0.011 16.4 0.0 1.7 1 0 0 1 1 1 1 Fn3-like domain Inhibitor_I9 PF05922.16 EXF77046.1 - 0.017 15.8 0.0 0.039 14.6 0.0 1.5 1 0 0 1 1 1 0 Peptidase inhibitor I9 BTB PF00651.31 EXF77047.1 - 5.7e-12 45.8 0.1 1.9e-11 44.2 0.0 1.8 2 0 0 2 2 2 1 BTB/POZ domain Glyco_hydro_3_C PF01915.22 EXF77048.1 - 3e-48 164.5 0.0 4.9e-48 163.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.6 EXF77048.1 - 2.8e-24 85.0 0.1 5.3e-24 84.1 0.1 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain Glyco_hydro_3 PF00933.21 EXF77048.1 - 2.5e-22 79.6 0.0 5e-22 78.7 0.0 1.4 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain ABC_membrane PF00664.23 EXF77049.1 - 6.2e-43 147.4 14.5 7.8e-43 147.1 14.5 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 EXF77049.1 - 3.1e-33 115.2 0.0 6.5e-33 114.1 0.0 1.6 1 0 0 1 1 1 1 ABC transporter AAA_16 PF13191.6 EXF77049.1 - 2e-06 28.3 0.0 4.3e-06 27.2 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain SMC_N PF02463.19 EXF77049.1 - 7.7e-05 22.2 0.0 0.017 14.6 0.0 2.3 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 EXF77049.1 - 0.00033 20.9 0.0 0.0017 18.7 0.0 2.0 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 EXF77049.1 - 0.0021 18.1 0.0 0.009 16.1 0.0 2.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_21 PF13304.6 EXF77049.1 - 0.0031 17.4 0.1 0.09 12.6 0.0 2.3 1 1 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_14 PF13173.6 EXF77049.1 - 0.0034 17.4 0.0 0.025 14.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 EXF77049.1 - 0.0036 17.2 0.0 0.011 15.6 0.0 1.7 2 0 0 2 2 2 1 RsgA GTPase AAA_25 PF13481.6 EXF77049.1 - 0.02 14.5 0.0 0.046 13.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EXF77049.1 - 0.023 14.8 0.0 0.067 13.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 EXF77049.1 - 0.033 14.6 0.0 0.19 12.1 0.0 2.2 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 EXF77049.1 - 0.037 13.8 0.0 0.1 12.4 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_7 PF12775.7 EXF77049.1 - 0.04 13.4 0.0 0.095 12.2 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region Zeta_toxin PF06414.12 EXF77049.1 - 0.049 12.9 0.0 0.15 11.4 0.0 1.7 1 0 0 1 1 1 0 Zeta toxin AAA_28 PF13521.6 EXF77049.1 - 0.055 13.7 0.0 0.12 12.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 EXF77049.1 - 0.079 12.9 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain ATPase_2 PF01637.18 EXF77049.1 - 0.081 12.8 0.0 0.21 11.5 0.0 1.7 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_18 PF13238.6 EXF77049.1 - 0.084 13.4 0.0 0.24 12.0 0.0 1.8 1 0 0 1 1 1 0 AAA domain Septin PF00735.18 EXF77049.1 - 0.092 12.0 0.0 0.16 11.2 0.0 1.3 1 0 0 1 1 1 0 Septin SbcCD_C PF13558.6 EXF77049.1 - 0.093 13.0 0.4 2.1 8.6 0.4 2.6 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_30 PF13604.6 EXF77049.1 - 0.12 12.1 0.0 0.27 10.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 EXF77049.1 - 0.16 11.9 0.3 0.51 10.3 0.0 2.0 3 0 0 3 3 2 0 NACHT domain CorA PF01544.18 EXF77050.1 - 1.8e-13 50.4 0.0 5.5e-13 48.9 0.0 1.8 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein SlyX PF04102.12 EXF77050.1 - 0.54 10.9 2.4 31 5.3 0.0 3.0 2 0 0 2 2 2 0 SlyX NAD_binding_10 PF13460.6 EXF77051.1 - 3.7e-08 33.5 0.0 5.9e-08 32.8 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EXF77051.1 - 2.1e-07 30.7 0.0 4.8e-07 29.5 0.0 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EXF77051.1 - 2.3e-07 30.1 0.0 3.5e-07 29.5 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NmrA PF05368.13 EXF77051.1 - 6.1e-06 26.0 0.1 9.7e-06 25.3 0.1 1.3 1 0 0 1 1 1 1 NmrA-like family GDP_Man_Dehyd PF16363.5 EXF77051.1 - 0.00027 20.4 0.0 0.00049 19.6 0.0 1.4 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 EXF77051.1 - 0.0028 16.9 0.0 0.99 8.5 0.0 2.2 2 0 0 2 2 2 2 Male sterility protein adh_short PF00106.25 EXF77051.1 - 0.052 13.0 0.1 0.13 11.7 0.0 1.7 2 0 0 2 2 2 0 short chain dehydrogenase p450 PF00067.22 EXF77052.1 - 2e-23 82.9 0.0 2.5e-22 79.3 0.0 2.2 2 0 0 2 2 2 2 Cytochrome P450 YpzI PF14140.6 EXF77053.1 - 1.9 8.3 6.4 64 3.4 0.8 3.5 3 0 0 3 3 3 0 YpzI-like protein RnlA_toxin PF15935.5 EXF77054.1 - 0.0057 16.5 0.0 0.0093 15.8 0.0 1.2 1 0 0 1 1 1 1 RNase LS, bacterial toxin DUF4646 PF15496.6 EXF77054.1 - 0.023 15.3 0.0 0.21 12.2 0.0 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4646) Cadherin_4 PF17803.1 EXF77054.1 - 0.22 12.1 2.6 0.45 11.2 2.6 1.4 1 0 0 1 1 1 0 Bacterial cadherin-like domain Sugar_tr PF00083.24 EXF77055.1 - 3.3e-73 247.1 14.8 4e-73 246.8 14.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF77055.1 - 2.8e-29 102.1 18.1 3.8e-29 101.7 18.1 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_4 PF06779.14 EXF77055.1 - 2.1e-09 37.2 3.9 4.2e-09 36.2 3.9 1.4 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB TRI12 PF06609.13 EXF77055.1 - 2e-08 33.1 2.0 3.1e-08 32.5 2.0 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MMPL PF03176.15 EXF77055.1 - 0.044 12.7 2.6 0.35 9.8 1.7 2.3 2 0 0 2 2 2 0 MMPL family DUF2069 PF09842.9 EXF77055.1 - 5.6 7.2 7.4 1.5 9.1 0.8 2.9 2 1 0 2 2 2 0 Predicted membrane protein (DUF2069) DUF1479 PF07350.12 EXF77056.1 - 2.3e-117 392.3 0.0 2.8e-117 392.0 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1479) Fungal_trans PF04082.18 EXF77057.1 - 6.3e-06 25.4 0.1 1e-05 24.8 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Cep3 PF16846.5 EXF77057.1 - 3.3e-05 22.6 0.0 7.3e-05 21.4 0.0 1.5 2 0 0 2 2 2 1 Centromere DNA-binding protein complex CBF3 subunit B Amidohydro_1 PF01979.20 EXF77058.1 - 1.9e-62 211.6 0.0 2.2e-62 211.4 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EXF77058.1 - 2.7e-14 53.5 0.0 5.2e-10 39.4 0.0 2.2 2 0 0 2 2 2 2 Amidohydrolase family YlbD_coat PF14071.6 EXF77058.1 - 0.041 14.2 0.0 1.3 9.3 0.0 2.4 2 0 0 2 2 2 0 Putative coat protein A_deaminase PF00962.22 EXF77058.1 - 0.062 12.6 0.0 0.11 11.8 0.0 1.4 1 0 0 1 1 1 0 Adenosine/AMP deaminase Abhydrolase_1 PF00561.20 EXF77059.1 - 8.1e-25 87.9 0.1 2.2e-24 86.5 0.1 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EXF77059.1 - 9.1e-16 59.1 0.3 1.1e-15 58.8 0.3 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EXF77059.1 - 1.1e-13 51.0 0.0 1.4e-12 47.5 0.0 2.0 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 EXF77059.1 - 3.8e-06 26.5 0.1 0.05 13.1 0.0 2.6 3 0 0 3 3 3 2 Prolyl oligopeptidase family Abhydrolase_4 PF08386.10 EXF77059.1 - 6.3e-06 26.3 0.0 1.1e-05 25.5 0.0 1.3 1 0 0 1 1 1 1 TAP-like protein Peptidase_S15 PF02129.18 EXF77059.1 - 0.00039 20.1 0.0 0.0006 19.5 0.0 1.3 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Esterase PF00756.20 EXF77059.1 - 0.012 15.2 0.0 0.021 14.5 0.0 1.6 1 0 0 1 1 1 0 Putative esterase Ndr PF03096.14 EXF77059.1 - 0.027 13.2 0.0 0.88 8.2 0.0 2.7 3 0 0 3 3 3 0 Ndr family FSH1 PF03959.13 EXF77059.1 - 0.11 12.1 0.1 0.17 11.6 0.1 1.2 1 0 0 1 1 1 0 Serine hydrolase (FSH1) DUF3575 PF12099.8 EXF77060.1 - 0.079 12.3 0.7 0.41 9.9 0.1 2.3 2 1 1 3 3 3 0 Protein of unknown function (DUF3575) Peptidase_S8 PF00082.22 EXF77061.1 - 1.9e-25 89.7 5.1 2.4e-25 89.4 5.1 1.2 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 EXF77061.1 - 2.4e-09 37.7 0.0 4.3e-09 36.9 0.0 1.4 1 0 0 1 1 1 1 Peptidase inhibitor I9 ADH_N PF08240.12 EXF77062.1 - 2.2e-28 98.3 0.3 4.8e-28 97.2 0.3 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EXF77062.1 - 2.1e-10 40.6 0.5 4.5e-10 39.6 0.1 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N_assoc PF13823.6 EXF77062.1 - 1.7e-06 27.8 0.1 4.4e-06 26.5 0.1 1.8 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-associated Glu_dehyd_C PF16912.5 EXF77062.1 - 3.4e-06 26.7 0.0 0.00014 21.4 0.0 2.3 2 0 0 2 2 2 1 Glucose dehydrogenase C-terminus AlaDh_PNT_C PF01262.21 EXF77062.1 - 0.0003 20.1 0.2 0.0007 19.0 0.2 1.6 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain HI0933_like PF03486.14 EXF77062.1 - 0.0018 17.0 0.1 0.0055 15.5 0.0 1.7 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox PF00070.27 EXF77062.1 - 0.038 14.6 0.3 0.31 11.6 0.1 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EXF77062.1 - 0.046 12.8 0.1 0.072 12.2 0.1 1.2 1 0 0 1 1 1 0 FAD binding domain TrkA_N PF02254.18 EXF77062.1 - 0.047 13.9 0.0 0.083 13.2 0.0 1.4 1 0 0 1 1 1 0 TrkA-N domain FAD_binding_3 PF01494.19 EXF77062.1 - 0.064 12.5 0.1 0.097 11.9 0.1 1.2 1 0 0 1 1 1 0 FAD binding domain Abhydrolase_9_N PF15420.6 EXF77063.1 - 0.15 12.1 9.7 0.32 11.0 9.7 1.5 1 0 0 1 1 1 0 Alpha/beta-hydrolase family N-terminus Gp23 PF07068.11 EXF77064.1 - 0.1 11.4 2.3 0.13 11.0 2.3 1.1 1 0 0 1 1 1 0 Major capsid protein Gp23 Iso_dh PF00180.20 EXF77065.1 - 5.1e-83 279.1 0.0 6.1e-83 278.8 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Ldh_1_N PF00056.23 EXF77066.1 - 3.7e-44 150.3 0.3 5.2e-44 149.8 0.3 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 EXF77066.1 - 5e-43 146.9 0.0 7.3e-43 146.4 0.0 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain 3Beta_HSD PF01073.19 EXF77066.1 - 4.7e-06 25.8 0.0 7.4e-06 25.2 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 EXF77066.1 - 0.0047 16.8 0.1 0.0085 16.0 0.1 1.5 1 0 0 1 1 1 1 NAD(P)H-binding Semialdhyde_dh PF01118.24 EXF77066.1 - 0.044 14.2 0.1 0.21 12.0 0.1 2.0 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain NmrA PF05368.13 EXF77066.1 - 0.092 12.3 0.1 0.19 11.3 0.1 1.5 1 1 0 1 1 1 0 NmrA-like family Fungal_trans PF04082.18 EXF77067.1 - 1.3e-15 57.2 0.7 1.9e-14 53.3 0.7 2.2 1 1 0 1 1 1 1 Fungal specific transcription factor domain SPX PF03105.19 EXF77067.1 - 0.12 12.3 1.6 30 4.4 0.0 2.4 2 1 0 2 2 2 0 SPX domain 2-Hacid_dh_C PF02826.19 EXF77069.1 - 2.6e-56 189.8 0.0 4.9e-56 188.9 0.0 1.4 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EXF77069.1 - 2.2e-20 72.7 0.0 2.5e-20 72.5 0.0 1.0 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 EXF77069.1 - 0.0061 16.7 0.0 0.011 15.9 0.0 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Glyco_hydro_7 PF00840.20 EXF77070.1 - 2.3e-183 609.9 16.8 2.6e-183 609.7 16.8 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 7 Zn_clus PF00172.18 EXF77071.1 - 2.3e-09 37.2 9.2 3.6e-09 36.6 9.2 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EXF77071.1 - 0.00011 21.4 0.1 0.00045 19.3 0.1 2.0 1 1 0 1 1 1 1 Fungal specific transcription factor domain SKA1 PF07160.12 EXF77071.1 - 1.3 8.8 11.6 3.1 7.6 11.6 1.6 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 Tim54 PF11711.8 EXF77071.1 - 1.6 7.4 8.7 3.3 6.4 8.7 1.4 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 SLC12 PF03522.15 EXF77071.1 - 3.1 6.7 10.5 0.33 9.9 6.3 1.4 2 0 0 2 2 2 0 Solute carrier family 12 AIF_C PF14721.6 EXF77071.1 - 5.9 7.3 7.5 16 5.9 7.5 1.7 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Sec62 PF03839.16 EXF77071.1 - 6.1 6.3 5.1 12 5.4 5.1 1.4 1 0 0 1 1 1 0 Translocation protein Sec62 ALMT PF11744.8 EXF77071.1 - 7.3 5.3 7.4 12 4.6 7.4 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter DivIVA PF05103.13 EXF77072.1 - 0.0044 17.1 2.2 0.12 12.5 1.7 2.4 2 0 0 2 2 2 1 DivIVA protein Moulting_cycle PF04870.16 EXF77072.1 - 0.21 10.8 6.3 0.38 10.0 6.3 1.3 1 0 0 1 1 1 0 Moulting cycle Pyr_redox_3 PF13738.6 EXF77073.1 - 1.2e-20 74.0 0.0 4e-20 72.3 0.0 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EXF77073.1 - 9e-16 57.9 0.0 5.7e-14 52.0 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 EXF77073.1 - 1.2e-15 57.0 0.0 3.6e-14 52.1 0.0 2.4 2 1 0 2 2 2 1 Flavin-binding monooxygenase-like K_oxygenase PF13434.6 EXF77073.1 - 5.1e-12 45.6 0.1 1.7e-10 40.6 0.0 2.6 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Shikimate_DH PF01488.20 EXF77073.1 - 7.5e-05 22.8 0.0 0.0045 17.1 0.0 2.3 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase Pyr_redox PF00070.27 EXF77073.1 - 0.00034 21.1 0.1 0.66 10.6 0.0 3.2 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EXF77073.1 - 0.00063 18.9 0.0 0.0061 15.7 0.0 2.2 3 0 0 3 3 3 1 Glucose inhibited division protein A FAD_binding_2 PF00890.24 EXF77073.1 - 0.0012 18.0 0.0 0.046 12.8 0.0 2.3 2 0 0 2 2 2 1 FAD binding domain NAD_binding_8 PF13450.6 EXF77073.1 - 0.0024 18.1 0.0 0.0063 16.7 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain 2-Hacid_dh_C PF02826.19 EXF77073.1 - 0.0028 17.0 0.0 0.019 14.3 0.0 2.0 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DAO PF01266.24 EXF77073.1 - 0.0037 16.9 0.0 0.48 10.0 0.0 2.4 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EXF77073.1 - 0.005 16.8 0.2 2.4 8.1 0.0 3.0 2 1 1 3 3 3 1 FAD-NAD(P)-binding ApbA PF02558.16 EXF77073.1 - 0.0062 16.2 0.2 0.13 11.9 0.0 2.6 2 1 1 3 3 3 1 Ketopantoate reductase PanE/ApbA FAD_binding_3 PF01494.19 EXF77073.1 - 0.015 14.6 0.0 0.039 13.2 0.0 1.7 1 0 0 1 1 1 0 FAD binding domain HI0933_like PF03486.14 EXF77073.1 - 0.025 13.3 0.0 0.095 11.4 0.0 1.8 2 0 0 2 2 2 0 HI0933-like protein 3HCDH_N PF02737.18 EXF77073.1 - 0.075 12.9 0.0 1.7 8.5 0.0 2.2 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain LigB PF02900.18 EXF77073.1 - 0.13 11.3 0.0 0.37 9.8 0.0 1.7 2 0 0 2 2 2 0 Catalytic LigB subunit of aromatic ring-opening dioxygenase IlvN PF07991.12 EXF77073.1 - 0.13 11.8 0.0 1.2 8.7 0.0 2.1 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain Lycopene_cycl PF05834.12 EXF77073.1 - 0.16 11.0 0.0 0.41 9.6 0.0 1.7 1 0 0 1 1 1 0 Lycopene cyclase protein ADH_N PF08240.12 EXF77074.1 - 1.8e-30 105.0 0.5 1.8e-30 105.0 0.5 1.9 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EXF77074.1 - 1.6e-20 73.4 0.1 3e-20 72.5 0.1 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EXF77074.1 - 0.00082 18.9 1.0 0.0015 18.1 1.0 1.6 1 1 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 EXF77074.1 - 0.0011 20.0 0.0 0.0021 19.1 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Pyr_redox_2 PF07992.14 EXF77074.1 - 0.0034 16.6 0.2 0.0062 15.8 0.2 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase 2-Hacid_dh_C PF02826.19 EXF77074.1 - 0.0049 16.2 0.0 0.0085 15.5 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Methyltransf_25 PF13649.6 EXF77074.1 - 0.026 15.2 0.1 0.047 14.4 0.1 1.4 1 0 0 1 1 1 0 Methyltransferase domain UDPG_MGDP_dh_N PF03721.14 EXF77074.1 - 0.059 12.9 0.1 0.097 12.2 0.1 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 3HCDH_N PF02737.18 EXF77074.1 - 0.068 13.0 0.1 0.12 12.3 0.1 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain AdoHcyase_NAD PF00670.21 EXF77074.1 - 0.072 13.2 0.2 0.16 12.0 0.2 1.5 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain UDPGT PF00201.18 EXF77075.1 - 2.7e-12 46.3 0.0 3.9e-12 45.7 0.0 1.1 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Ribosomal_L36e PF01158.18 EXF77075.1 - 0.011 15.9 0.0 0.021 15.0 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L36e DUF1645 PF07816.11 EXF77076.1 - 0.056 14.0 5.0 0.16 12.5 5.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1645) Candida_ALS PF05792.13 EXF77077.1 - 2.8e-22 79.0 185.7 1.4e-06 28.7 6.5 186.2 190 2 0 190 190 190 116 Candida agglutinin-like (ALS) DUF1905 PF08922.11 EXF77077.1 - 6.8 6.8 27.4 75 3.5 0.0 11.3 5 4 10 15 15 15 0 Domain of unknown function (DUF1905) SNO PF01174.19 EXF77079.1 - 4.4e-52 176.7 0.0 9.2e-41 139.8 0.0 2.1 1 1 1 2 2 2 2 SNO glutamine amidotransferase family GATase_3 PF07685.14 EXF77079.1 - 6.9e-08 32.3 0.0 2.5e-07 30.5 0.0 1.8 2 0 0 2 2 2 1 CobB/CobQ-like glutamine amidotransferase domain DJ-1_PfpI PF01965.24 EXF77079.1 - 0.00013 21.8 0.0 0.00024 20.9 0.0 1.5 1 0 0 1 1 1 1 DJ-1/PfpI family Peptidase_S51 PF03575.17 EXF77079.1 - 0.00037 20.2 0.0 0.00053 19.7 0.0 1.2 1 0 0 1 1 1 1 Peptidase family S51 GATase PF00117.28 EXF77079.1 - 0.00054 19.8 0.0 0.012 15.4 0.0 2.1 1 1 0 1 1 1 1 Glutamine amidotransferase class-I SOR_SNZ PF01680.17 EXF77080.1 - 4.7e-103 343.4 6.9 6.2e-103 343.0 6.9 1.1 1 0 0 1 1 1 1 SOR/SNZ family ThiG PF05690.14 EXF77080.1 - 2.7e-10 40.0 3.7 3e-07 30.0 0.1 2.4 2 0 0 2 2 2 2 Thiazole biosynthesis protein ThiG His_biosynth PF00977.21 EXF77080.1 - 0.0011 18.5 0.4 0.17 11.3 0.1 3.1 2 1 0 2 2 2 1 Histidine biosynthesis protein Dus PF01207.17 EXF77080.1 - 0.0036 16.5 2.7 0.48 9.5 0.1 2.6 3 1 0 3 3 3 2 Dihydrouridine synthase (Dus) TetR_C_27 PF17935.1 EXF77080.1 - 0.0057 16.7 0.0 0.015 15.3 0.0 1.7 1 0 0 1 1 1 1 Tetracyclin repressor-like, C-terminal domain IGPS PF00218.21 EXF77080.1 - 0.0078 15.4 0.3 0.1 11.8 0.0 2.5 2 1 0 2 2 2 1 Indole-3-glycerol phosphate synthase NanE PF04131.14 EXF77080.1 - 0.015 14.5 0.7 0.25 10.5 0.0 2.5 2 1 0 2 2 2 0 Putative N-acetylmannosamine-6-phosphate epimerase NMO PF03060.15 EXF77080.1 - 0.24 10.8 9.0 0.14 11.5 1.5 2.2 2 0 0 2 2 2 0 Nitronate monooxygenase WD40 PF00400.32 EXF77082.1 - 1.3e-11 44.8 2.4 0.0098 16.7 0.1 4.7 4 0 0 4 4 4 4 WD domain, G-beta repeat WD40_like PF17005.5 EXF77082.1 - 0.0018 17.7 0.0 0.004 16.5 0.0 1.5 2 0 0 2 2 2 1 WD40-like domain PQQ_3 PF13570.6 EXF77082.1 - 0.056 14.0 0.4 12 6.5 0.0 3.8 4 0 0 4 4 4 0 PQQ-like domain Nup160 PF11715.8 EXF77082.1 - 0.14 10.8 0.0 8.4 4.9 0.0 2.1 2 0 0 2 2 2 0 Nucleoporin Nup120/160 DUF3237 PF11578.8 EXF77083.1 - 1.3e-37 128.9 0.1 1.5e-37 128.7 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3237) GRAM PF02893.20 EXF77084.1 - 1e-31 109.1 1.4 9.9e-20 70.5 0.0 3.4 3 0 0 3 3 3 3 GRAM domain Glyco_transf_28 PF03033.20 EXF77084.1 - 3e-30 105.1 0.0 1e-29 103.3 0.0 1.9 2 0 0 2 2 2 1 Glycosyltransferase family 28 N-terminal domain PH PF00169.29 EXF77084.1 - 6.2e-15 55.6 0.0 2.3e-14 53.8 0.0 2.1 2 0 0 2 2 2 1 PH domain PH_11 PF15413.6 EXF77084.1 - 3.2e-06 27.5 1.3 4.4e-05 23.9 1.3 2.6 1 1 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.6 EXF77084.1 - 6.1e-05 23.2 0.2 0.00022 21.4 0.0 2.0 2 0 0 2 2 2 1 Pleckstrin homology domain UDPGT PF00201.18 EXF77084.1 - 0.00034 19.5 0.0 0.0006 18.7 0.0 1.3 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase NIF PF03031.18 EXF77086.1 - 1.4e-27 96.4 0.1 5.3e-27 94.5 0.0 1.9 2 0 0 2 2 2 1 NLI interacting factor-like phosphatase BRCT PF00533.26 EXF77086.1 - 2.9e-07 30.8 0.1 8.5e-07 29.3 0.0 1.9 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 EXF77086.1 - 1.7e-05 24.7 0.0 5.5e-05 23.0 0.0 1.9 1 0 0 1 1 1 1 twin BRCT domain RTT107_BRCT_5 PF16770.5 EXF77086.1 - 0.0042 17.0 1.1 0.0072 16.2 0.0 2.0 3 0 0 3 3 3 1 Regulator of Ty1 transposition protein 107 BRCT domain BRCT_2 PF16589.5 EXF77086.1 - 0.0055 17.1 0.0 0.012 15.9 0.0 1.6 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain BRCT_3 PF18428.1 EXF77086.1 - 0.038 14.1 0.9 0.11 12.6 0.9 1.7 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain LIG3_BRCT PF16759.5 EXF77086.1 - 0.12 12.6 0.1 0.31 11.4 0.1 1.6 1 0 0 1 1 1 0 DNA ligase 3 BRCT domain GRIM-19 PF06212.12 EXF77087.1 - 0.00011 22.2 1.2 0.00041 20.3 1.2 1.9 1 1 0 1 1 1 1 GRIM-19 protein FAD_binding_3 PF01494.19 EXF77088.1 - 8.6e-22 77.9 0.2 9.2e-13 48.2 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain Pyr_redox_2 PF07992.14 EXF77088.1 - 7.6e-08 31.9 0.9 0.00083 18.7 0.2 2.2 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EXF77088.1 - 1.1e-07 32.0 0.5 4.8e-07 29.9 0.3 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EXF77088.1 - 4e-06 26.6 1.7 0.0016 18.1 0.4 2.5 2 1 0 2 2 2 2 FAD dependent oxidoreductase FAD_oxidored PF12831.7 EXF77088.1 - 3.7e-05 23.3 0.1 5.5e-05 22.7 0.1 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Trp_halogenase PF04820.14 EXF77088.1 - 4.5e-05 22.5 0.4 0.00095 18.1 0.1 2.3 2 0 0 2 2 2 1 Tryptophan halogenase HI0933_like PF03486.14 EXF77088.1 - 0.00012 20.9 0.1 0.00041 19.2 0.0 1.7 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox PF00070.27 EXF77088.1 - 0.00013 22.5 0.2 0.0016 18.9 0.1 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 EXF77088.1 - 0.0003 20.2 0.6 0.33 10.2 0.0 2.2 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase Pyr_redox_3 PF13738.6 EXF77088.1 - 0.00035 19.9 0.1 0.0055 16.0 0.1 2.4 2 1 1 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EXF77088.1 - 0.00063 18.9 2.5 0.00083 18.5 0.7 2.0 3 0 0 3 3 3 1 FAD binding domain Thi4 PF01946.17 EXF77088.1 - 0.0013 18.0 0.1 0.0023 17.2 0.1 1.3 1 0 0 1 1 1 1 Thi4 family Lycopene_cycl PF05834.12 EXF77088.1 - 0.0062 15.6 0.1 0.013 14.6 0.1 1.5 1 1 0 1 1 1 1 Lycopene cyclase protein GIDA PF01134.22 EXF77088.1 - 0.0094 15.1 1.0 0.026 13.6 1.0 1.7 1 1 0 1 1 1 1 Glucose inhibited division protein A ApbA PF02558.16 EXF77088.1 - 0.012 15.3 0.2 0.021 14.5 0.2 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA NAD_binding_9 PF13454.6 EXF77088.1 - 0.036 14.1 0.4 1 9.3 0.1 2.4 2 0 0 2 2 2 0 FAD-NAD(P)-binding Shikimate_DH PF01488.20 EXF77088.1 - 0.18 11.9 0.0 0.31 11.1 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase 3HCDH_N PF02737.18 EXF77088.1 - 0.21 11.4 0.2 0.35 10.7 0.2 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Bac_rhamnosid_C PF17390.2 EXF77089.1 - 1.4e-14 53.6 0.1 4.2e-14 52.1 0.1 1.8 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase C-terminal domain Bac_rhamnosid6H PF17389.2 EXF77089.1 - 0.00022 20.6 0.0 0.0023 17.2 0.0 2.0 2 0 0 2 2 2 1 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain DUF1080 PF06439.11 EXF77089.1 - 0.071 13.2 0.0 0.37 10.9 0.0 2.1 1 1 0 1 1 1 0 Domain of Unknown Function (DUF1080) Cnd1_N PF12922.7 EXF77090.1 - 4.2e-63 212.1 0.1 4.9e-62 208.7 0.0 2.5 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1, N-term Cnd1 PF12717.7 EXF77090.1 - 1.5e-48 164.9 7.2 4.9e-45 153.5 0.2 3.2 4 0 0 4 4 4 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 EXF77090.1 - 6.2e-10 38.5 3.0 0.017 15.3 0.0 6.2 5 0 0 5 5 5 2 HEAT repeat HEAT_2 PF13646.6 EXF77090.1 - 3.4e-09 37.0 1.5 0.0007 19.9 0.2 4.1 3 1 1 4 4 4 2 HEAT repeats RTP1_C1 PF10363.9 EXF77090.1 - 8.2e-05 22.8 0.1 0.044 14.0 0.0 3.6 2 1 0 2 2 2 1 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_EZ PF13513.6 EXF77090.1 - 9e-05 22.9 5.9 0.13 12.8 0.3 4.9 4 0 0 4 4 4 1 HEAT-like repeat Adaptin_N PF01602.20 EXF77090.1 - 0.00035 19.3 5.4 0.014 14.0 0.2 3.3 3 1 0 3 3 3 2 Adaptin N terminal region Cnd3 PF12719.7 EXF77090.1 - 0.0027 16.9 0.8 0.0027 16.9 0.8 3.2 3 1 1 4 4 4 1 Nuclear condensing complex subunits, C-term domain DUF5445 PF17520.2 EXF77090.1 - 0.063 13.1 0.3 1.9 8.4 0.0 2.8 3 0 0 3 3 3 0 Family of unknown function (DUF5445) Pkinase PF00069.25 EXF77091.1 - 1.4e-43 149.2 0.0 1.4e-40 139.3 0.0 2.7 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EXF77091.1 - 1.3e-14 54.1 0.0 1.9e-08 33.9 0.0 3.7 4 0 0 4 4 4 2 Protein tyrosine kinase APH PF01636.23 EXF77091.1 - 8.5e-06 25.9 0.1 0.1 12.5 0.0 2.5 1 1 1 2 2 2 2 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EXF77091.1 - 0.00044 19.2 0.1 0.0012 17.7 0.0 1.7 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 EXF77091.1 - 0.011 15.1 0.0 0.64 9.3 0.0 2.5 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EXF77091.1 - 0.038 13.3 0.0 4.4 6.5 0.0 2.3 2 0 0 2 2 2 0 Kinase-like Ribosomal_L27A PF00828.19 EXF77092.1 - 1.7e-21 77.2 0.0 2.3e-21 76.8 0.0 1.2 1 1 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Helicase_C_2 PF13307.6 EXF77093.1 - 4.2e-59 199.6 0.0 1.6e-58 197.7 0.0 2.0 2 0 0 2 2 2 1 Helicase C-terminal domain DEAD_2 PF06733.15 EXF77093.1 - 8.7e-47 159.0 0.0 1.5e-46 158.2 0.0 1.4 1 0 0 1 1 1 1 DEAD_2 ResIII PF04851.15 EXF77093.1 - 0.03 14.3 0.0 10 6.1 0.0 2.4 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit Goodbye PF17109.5 EXF77094.1 - 1.8e-25 89.7 0.5 9.2e-25 87.4 0.1 2.4 2 0 0 2 2 2 1 fungal STAND N-terminal Goodbye domain TPR_12 PF13424.6 EXF77094.1 - 1.8e-12 47.4 2.9 2.1e-06 27.9 0.4 3.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 EXF77094.1 - 9.3e-11 41.1 8.2 0.012 15.4 0.0 4.3 5 0 0 5 5 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 EXF77094.1 - 4.2e-09 35.8 4.9 0.32 11.1 0.0 5.4 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 EXF77094.1 - 8.4e-07 28.7 5.5 0.018 15.2 0.4 4.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 EXF77094.1 - 6e-06 26.0 7.5 0.066 13.3 0.0 4.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 EXF77094.1 - 3.1e-05 24.4 2.2 0.18 12.3 0.0 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat AAA_16 PF13191.6 EXF77094.1 - 4.4e-05 23.9 0.0 0.0003 21.2 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain NACHT PF05729.12 EXF77094.1 - 5.6e-05 23.1 0.0 0.00013 21.9 0.0 1.6 1 0 0 1 1 1 1 NACHT domain TPR_6 PF13174.6 EXF77094.1 - 0.0018 18.8 1.6 9.6 7.1 0.1 4.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 EXF77094.1 - 0.0063 17.2 6.2 3.6 8.7 0.0 5.5 5 1 1 6 6 4 1 Tetratricopeptide repeat AAA_22 PF13401.6 EXF77094.1 - 0.0072 16.6 0.1 0.044 14.1 0.0 2.3 2 0 0 2 2 2 1 AAA domain TPR_10 PF13374.6 EXF77094.1 - 0.017 15.0 3.3 13 5.8 0.4 4.1 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF2075 PF09848.9 EXF77094.1 - 0.022 14.0 0.0 0.059 12.6 0.0 1.7 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) DUF3783 PF12646.7 EXF77094.1 - 0.024 14.6 0.0 9.9 6.2 0.0 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3783) FlgN PF05130.12 EXF77094.1 - 0.035 14.6 1.7 0.73 10.3 0.5 3.6 3 0 0 3 3 2 0 FlgN protein RNA_helicase PF00910.22 EXF77094.1 - 0.12 12.7 0.1 0.68 10.4 0.0 2.3 2 0 0 2 2 2 0 RNA helicase SnoaL_2 PF12680.7 EXF77096.1 - 4.2e-06 27.3 0.0 5.2e-06 27.0 0.0 1.1 1 0 0 1 1 1 1 SnoaL-like domain SnoaL PF07366.12 EXF77096.1 - 0.023 14.5 0.0 0.15 11.8 0.0 1.9 1 1 0 1 1 1 0 SnoaL-like polyketide cyclase Glyco_hydro_43 PF04616.14 EXF77097.1 - 1.3e-62 211.8 11.1 6.9e-55 186.4 3.4 2.3 2 0 0 2 2 2 2 Glycosyl hydrolases family 43 Laminin_G_3 PF13385.6 EXF77097.1 - 8.2e-20 71.5 3.3 2.4e-19 70.0 2.1 2.6 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Glyco_hydro_32N PF00251.20 EXF77097.1 - 1e-07 31.8 7.8 0.00061 19.5 0.6 3.2 3 0 0 3 3 3 2 Glycosyl hydrolases family 32 N-terminal domain Sialidase PF02973.16 EXF77097.1 - 0.001 18.6 0.1 0.002 17.7 0.1 1.4 1 0 0 1 1 1 1 Sialidase, N-terminal domain Pectate_lyase PF03211.13 EXF77098.1 - 2.8e-84 281.7 11.1 3.2e-84 281.5 11.1 1.0 1 0 0 1 1 1 1 Pectate lyase HAD_2 PF13419.6 EXF77099.1 - 3.6e-10 40.2 0.0 5.9e-10 39.5 0.0 1.3 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EXF77099.1 - 2e-09 38.1 0.0 9.8e-08 32.5 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EXF77099.1 - 2.3e-06 27.6 0.0 4e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like DUF3226 PF11536.8 EXF77099.1 - 0.022 14.5 0.0 0.046 13.4 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3226) HTH_1 PF00126.27 EXF77099.1 - 0.11 12.4 0.0 0.2 11.6 0.0 1.4 1 0 0 1 1 1 0 Bacterial regulatory helix-turn-helix protein, lysR family NmrA PF05368.13 EXF77100.1 - 2e-16 60.3 0.2 2.4e-16 60.0 0.2 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EXF77100.1 - 1.2e-12 48.1 0.3 2.5e-12 47.1 0.1 1.7 2 0 0 2 2 2 1 NAD(P)H-binding DapB_N PF01113.20 EXF77100.1 - 0.027 14.6 0.1 0.051 13.7 0.1 1.5 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus adh_short PF00106.25 EXF77101.1 - 5.9e-31 107.4 0.0 2.3e-23 82.7 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EXF77101.1 - 3e-18 66.2 0.0 4.4e-13 49.3 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF77101.1 - 3.4e-09 36.9 0.0 5.1e-09 36.3 0.0 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EXF77101.1 - 0.0016 18.0 0.3 0.0074 15.8 0.3 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EXF77101.1 - 0.003 17.0 0.2 0.028 13.8 0.1 2.0 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 EXF77101.1 - 0.0084 15.3 0.0 0.011 14.9 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein T6SS_VasJ PF16989.5 EXF77102.1 - 0.11 11.9 0.0 0.26 10.7 0.0 1.5 1 0 0 1 1 1 0 Type VI secretion, EvfE, EvfF, ImpA, BimE, VC_A0119, VasJ Abhydrolase_2 PF02230.16 EXF77103.1 - 1.4e-23 83.8 0.1 1.6e-10 41.2 0.0 3.0 3 0 0 3 3 3 3 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.21 EXF77103.1 - 4.9e-06 26.2 0.3 0.00019 21.0 0.0 3.1 3 1 1 4 4 4 1 Prolyl oligopeptidase family BAAT_C PF08840.11 EXF77103.1 - 0.0079 16.1 0.2 0.019 14.9 0.0 1.6 2 0 0 2 2 2 1 BAAT / Acyl-CoA thioester hydrolase C terminal Hydrolase_4 PF12146.8 EXF77103.1 - 0.019 14.2 1.0 0.64 9.2 0.0 2.9 3 0 0 3 3 3 0 Serine aminopeptidase, S33 LIP PF03583.14 EXF77103.1 - 0.025 13.9 0.1 0.065 12.6 0.0 1.6 2 0 0 2 2 2 0 Secretory lipase Abhydrolase_4 PF08386.10 EXF77103.1 - 0.18 11.9 0.0 0.46 10.6 0.0 1.6 1 0 0 1 1 1 0 TAP-like protein NAD_binding_10 PF13460.6 EXF77104.1 - 2e-18 67.0 0.0 2.6e-18 66.6 0.0 1.1 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EXF77104.1 - 0.0093 15.5 0.0 0.014 15.0 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family adh_short PF00106.25 EXF77104.1 - 0.034 13.6 0.0 0.047 13.1 0.0 1.2 1 0 0 1 1 1 0 short chain dehydrogenase Abhydrolase_6 PF12697.7 EXF77105.1 - 0.0011 19.6 1.7 0.0033 18.1 0.6 2.2 2 1 0 2 2 2 1 Alpha/beta hydrolase family DUF3810 PF12725.7 EXF77105.1 - 0.05 12.9 0.0 0.085 12.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) Abhydrolase_1 PF00561.20 EXF77105.1 - 0.071 12.7 0.0 0.17 11.5 0.0 1.4 1 1 0 1 1 1 0 alpha/beta hydrolase fold HET PF06985.11 EXF77106.1 - 3.1e-12 47.1 7.0 3.7e-11 43.6 0.9 2.3 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) PCMT PF01135.19 EXF77107.1 - 1.2e-56 191.8 0.0 1.8e-56 191.2 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 EXF77107.1 - 1.3e-05 25.0 0.0 2e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 EXF77107.1 - 0.00082 19.4 0.0 0.0013 18.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF77107.1 - 0.0019 18.9 0.0 0.0035 18.0 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EXF77107.1 - 0.0036 16.9 0.0 0.0071 15.9 0.0 1.4 2 0 0 2 2 2 1 Methyltransferase small domain Ubie_methyltran PF01209.18 EXF77107.1 - 0.046 13.1 0.0 0.088 12.1 0.0 1.4 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_11 PF08241.12 EXF77107.1 - 0.07 13.8 0.0 0.13 12.9 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain MetW PF07021.12 EXF77107.1 - 0.093 12.3 0.0 0.15 11.6 0.0 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Methyltransf_23 PF13489.6 EXF77107.1 - 0.1 12.4 0.0 0.15 11.9 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain DUF2370 PF10176.9 EXF77108.1 - 7.4e-90 300.5 1.2 1.5e-89 299.6 0.0 2.0 2 1 0 2 2 2 1 Protein of unknown function (DUF2370) CD99L2 PF12301.8 EXF77108.1 - 0.36 11.1 4.7 0.83 9.9 4.7 1.5 1 0 0 1 1 1 0 CD99 antigen like protein 2 Mito_carr PF00153.27 EXF77109.1 - 3.2e-51 171.2 5.5 1.1e-21 76.5 0.3 4.0 4 0 0 4 4 4 4 Mitochondrial carrier protein DNase_NucA_NucB PF14040.6 EXF77111.1 - 0.28 11.6 1.6 2 8.8 0.2 2.4 1 1 1 2 2 2 0 Deoxyribonuclease NucA/NucB Fer4 PF00037.27 EXF77113.1 - 1.6e-13 49.8 16.5 6.1e-08 32.2 3.6 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_7 PF12838.7 EXF77113.1 - 7.4e-13 48.9 10.3 1.3e-12 48.1 10.3 1.4 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_21 PF14697.6 EXF77113.1 - 1.7e-09 37.6 31.5 6.2e-06 26.2 12.3 2.2 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_16 PF13484.6 EXF77113.1 - 3.5e-09 37.4 11.9 0.00012 22.9 0.8 2.6 2 1 1 3 3 2 2 4Fe-4S double cluster binding domain Fer4_10 PF13237.6 EXF77113.1 - 9.9e-09 35.2 21.2 2e-06 27.8 12.1 2.0 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_9 PF13187.6 EXF77113.1 - 1.6e-08 34.5 9.0 3.1e-08 33.7 9.0 1.5 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_8 PF13183.6 EXF77113.1 - 1.1e-06 29.0 20.1 0.00022 21.6 11.6 2.4 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_6 PF12837.7 EXF77113.1 - 1.5e-06 28.0 17.1 0.0004 20.3 5.4 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_2 PF12797.7 EXF77113.1 - 3.6e-06 26.7 11.4 0.0084 16.2 1.5 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_4 PF12800.7 EXF77113.1 - 1.1e-05 25.5 11.7 0.00034 20.9 2.0 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_17 PF13534.6 EXF77113.1 - 0.00022 21.7 11.1 0.034 14.7 12.5 2.4 1 1 2 3 3 3 3 4Fe-4S dicluster domain c-SKI_SMAD_bind PF08782.10 EXF77113.1 - 0.011 15.9 5.8 0.51 10.6 0.3 2.4 1 1 1 2 2 2 0 c-SKI Smad4 binding domain ETF_QO PF05187.13 EXF77113.1 - 0.055 13.6 5.6 0.2 11.8 0.4 2.3 1 1 1 2 2 2 0 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S Fer4_13 PF13370.6 EXF77113.1 - 0.065 13.8 14.9 0.74 10.4 4.3 2.7 2 1 1 3 3 3 0 4Fe-4S single cluster domain of Ferredoxin I Fer4_18 PF13746.6 EXF77113.1 - 0.09 13.0 9.1 1.1 9.4 1.4 2.3 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_3 PF12798.7 EXF77113.1 - 0.24 12.4 15.5 0.42 11.7 3.3 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_22 PF17179.4 EXF77113.1 - 0.64 10.9 11.8 2.1 9.3 1.6 2.4 1 1 1 2 2 2 0 4Fe-4S dicluster domain PP-binding PF00550.25 EXF77114.1 - 3.9e-11 43.1 0.1 5.7e-11 42.6 0.1 1.2 1 0 0 1 1 1 1 Phosphopantetheine attachment site PP-binding_2 PF14573.6 EXF77114.1 - 2.9e-05 24.2 0.2 3.7e-05 23.9 0.2 1.2 1 0 0 1 1 1 1 Acyl-carrier zf-CCCH PF00642.24 EXF77115.1 - 6.6e-11 41.8 8.6 1.6e-05 24.7 2.1 2.4 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 EXF77115.1 - 1.7e-10 40.4 11.8 2.8e-05 23.8 3.5 2.5 2 0 0 2 2 2 2 CCCH-type zinc finger zf_CCCH_4 PF18345.1 EXF77115.1 - 4.6e-10 39.2 17.4 7.5e-05 22.6 4.2 2.4 2 0 0 2 2 2 2 Zinc finger domain Torus PF16131.5 EXF77115.1 - 5.3e-09 36.7 5.7 0.00011 22.8 0.5 2.4 1 1 1 2 2 2 2 Torus domain zf-CCCH_3 PF15663.5 EXF77115.1 - 0.00029 21.0 2.3 0.00038 20.7 1.2 1.7 2 0 0 2 2 2 1 Zinc-finger containing family zf-CCCH_2 PF14608.6 EXF77115.1 - 0.041 14.4 20.7 0.084 13.4 5.4 2.8 3 0 0 3 3 3 0 RNA-binding, Nab2-type zinc finger Transp_cyt_pur PF02133.15 EXF77116.1 - 2e-24 86.2 26.5 1.6e-23 83.3 26.1 2.0 1 1 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Glyco_hydro_47 PF01532.20 EXF77117.1 - 5.4e-173 576.1 0.0 6.2e-173 575.9 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Alpha-L-AF_C PF06964.12 EXF77118.1 - 1.1e-31 110.2 0.1 1.8e-31 109.6 0.1 1.3 1 0 0 1 1 1 1 Alpha-L-arabinofuranosidase C-terminal domain FlgD_ig PF13860.6 EXF77118.1 - 0.03 14.2 0.8 0.06 13.2 0.8 1.4 1 0 0 1 1 1 0 FlgD Ig-like domain Sugar_tr PF00083.24 EXF77119.1 - 1.1e-100 337.6 14.1 1.3e-100 337.4 14.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF77119.1 - 4.8e-34 117.8 28.8 6.3e-25 87.8 10.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EXF77119.1 - 1.8e-09 36.7 9.0 2.9e-06 26.1 0.6 2.4 2 0 0 2 2 2 2 MFS/sugar transport protein EphA2_TM PF14575.6 EXF77120.1 - 0.0023 18.8 0.0 0.0026 18.6 0.0 1.1 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain Shisa PF13908.6 EXF77120.1 - 0.0063 16.8 0.1 0.0081 16.4 0.1 1.1 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator Adeno_E3_CR2 PF02439.15 EXF77120.1 - 0.14 12.0 5.9 0.21 11.4 5.9 1.3 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 RCR PF12273.8 EXF77120.1 - 0.14 12.8 2.0 0.32 11.7 1.9 1.7 1 1 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red Mid2 PF04478.12 EXF77121.1 - 0.0019 18.1 0.5 0.0049 16.7 0.1 1.8 2 0 0 2 2 2 1 Mid2 like cell wall stress sensor CD99L2 PF12301.8 EXF77121.1 - 0.0026 18.1 0.4 0.0071 16.7 0.1 1.8 1 1 0 1 1 1 1 CD99 antigen like protein 2 Proton_antipo_C PF01010.19 EXF77121.1 - 0.13 11.9 0.0 0.2 11.2 0.0 1.4 1 1 0 1 1 1 0 NADH-dehyrogenase subunit F, TMs, (complex I) C-terminus adh_short PF00106.25 EXF77122.1 - 1.8e-29 102.6 0.0 2.5e-29 102.1 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF77122.1 - 5.1e-23 81.8 0.0 7.5e-23 81.3 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF77122.1 - 8.6e-09 35.6 0.0 1.6e-06 28.1 0.0 2.2 2 0 0 2 2 2 2 KR domain Epimerase PF01370.21 EXF77122.1 - 0.17 11.4 0.0 0.27 10.7 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family FMO-like PF00743.19 EXF77123.1 - 6.7e-16 57.8 0.0 2.2e-15 56.1 0.0 1.8 2 1 0 2 2 2 1 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.6 EXF77123.1 - 9.5e-11 41.8 0.0 3.7e-10 39.9 0.0 2.1 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 EXF77123.1 - 5e-08 32.6 0.0 4.1e-06 26.3 0.0 2.7 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EXF77123.1 - 6.8e-06 25.5 0.0 0.0025 17.1 0.0 2.4 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EXF77123.1 - 6e-05 22.3 0.0 0.00058 19.1 0.0 2.2 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 EXF77123.1 - 0.0024 17.9 0.3 0.15 12.0 0.0 3.2 3 0 0 3 3 3 1 FAD-NAD(P)-binding DAO PF01266.24 EXF77123.1 - 0.016 14.8 0.2 11 5.5 0.0 3.1 1 1 2 3 3 3 0 FAD dependent oxidoreductase Thi4 PF01946.17 EXF77123.1 - 0.031 13.5 0.0 8.5 5.5 0.0 2.8 3 0 0 3 3 3 0 Thi4 family Amino_oxidase PF01593.24 EXF77123.1 - 0.057 12.7 0.0 0.59 9.4 0.0 2.5 2 1 0 2 2 2 0 Flavin containing amine oxidoreductase Fungal_trans PF04082.18 EXF77124.1 - 4.7e-06 25.8 0.2 8.5e-06 25.0 0.2 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF77124.1 - 1.2e-05 25.3 8.0 2e-05 24.6 8.0 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Elf1 PF05129.13 EXF77124.1 - 0.37 10.9 3.6 0.73 9.9 3.6 1.4 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like MFS_1 PF07690.16 EXF77125.1 - 1.6e-32 112.9 31.8 1.6e-32 112.9 31.8 1.7 1 1 1 2 2 2 2 Major Facilitator Superfamily Na_Pi_cotrans PF02690.15 EXF77125.1 - 0.008 16.3 4.0 0.13 12.3 0.3 2.6 2 0 0 2 2 2 2 Na+/Pi-cotransporter Lactamase_B PF00753.27 EXF77126.1 - 4.8e-10 39.8 0.1 1.1e-09 38.6 0.0 1.6 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EXF77126.1 - 0.0094 15.5 0.0 0.022 14.3 0.0 1.6 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Pyr_redox_3 PF13738.6 EXF77127.1 - 6.4e-14 51.9 0.0 5e-13 49.0 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 EXF77127.1 - 1.7e-13 49.9 0.0 3.3e-13 48.9 0.0 1.4 2 0 0 2 2 2 1 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 EXF77127.1 - 1.5e-11 44.1 0.0 1.8e-09 37.3 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EXF77127.1 - 3.4e-09 36.3 0.0 2.7e-07 30.1 0.0 2.8 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.24 EXF77127.1 - 8.6e-08 32.1 0.2 0.001 18.7 0.1 2.9 2 1 1 3 3 3 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EXF77127.1 - 6.3e-07 29.5 0.1 5.6e-06 26.5 0.0 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EXF77127.1 - 0.00064 18.9 0.0 0.0014 17.8 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain NAD_binding_9 PF13454.6 EXF77127.1 - 0.0017 18.4 0.1 9.2 6.2 0.0 3.8 3 1 0 3 3 3 1 FAD-NAD(P)-binding HI0933_like PF03486.14 EXF77127.1 - 0.0026 16.5 0.0 0.13 10.9 0.1 2.6 3 0 0 3 3 3 1 HI0933-like protein Thi4 PF01946.17 EXF77127.1 - 0.005 16.1 0.0 0.012 14.9 0.0 1.5 1 0 0 1 1 1 1 Thi4 family Pyr_redox PF00070.27 EXF77127.1 - 0.012 16.1 0.3 2.9 8.5 0.3 2.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EXF77127.1 - 0.041 13.1 0.8 1.6 7.9 0.7 2.2 1 1 1 2 2 2 0 FAD binding domain NAD_binding_7 PF13241.6 EXF77127.1 - 0.049 14.1 0.0 1.1 9.7 0.0 2.4 2 0 0 2 2 2 0 Putative NAD(P)-binding Shikimate_DH PF01488.20 EXF77127.1 - 0.087 12.9 0.0 0.19 11.8 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Abhydrolase_3 PF07859.13 EXF77128.1 - 1e-53 182.3 0.0 1.3e-53 182.0 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 EXF77128.1 - 4.4e-13 48.9 0.4 1.9e-12 46.8 0.4 1.8 1 1 0 1 1 1 1 Carboxylesterase family Peptidase_S9 PF00326.21 EXF77128.1 - 0.00028 20.4 0.1 0.16 11.5 0.0 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 EXF77128.1 - 0.0037 17.9 0.1 0.0056 17.3 0.1 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Chlorophyllase2 PF12740.7 EXF77128.1 - 0.027 13.4 0.0 0.039 12.9 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase enzyme DLH PF01738.18 EXF77128.1 - 0.09 12.3 0.0 0.42 10.1 0.0 1.9 2 0 0 2 2 2 0 Dienelactone hydrolase family BLACT_WH PF17778.1 EXF77128.1 - 0.14 12.1 0.8 6.5 6.8 0.1 2.6 2 0 0 2 2 2 0 Beta-lactamase associated winged helix domain adh_short_C2 PF13561.6 EXF77129.1 - 1.6e-56 191.5 3.1 2e-56 191.2 3.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF77129.1 - 6.7e-47 159.5 2.9 9.2e-47 159.0 2.9 1.1 1 0 0 1 1 1 1 short chain dehydrogenase Ecm33 PF12454.8 EXF77129.1 - 0.037 14.2 0.4 3.7 7.8 0.1 2.7 2 0 0 2 2 2 0 GPI-anchored cell wall organization protein ADH_N PF08240.12 EXF77130.1 - 3.3e-19 68.8 1.8 5.8e-19 68.0 1.8 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EXF77130.1 - 3e-15 56.4 0.1 6.1e-15 55.4 0.0 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EXF77130.1 - 1.6e-11 45.4 0.0 3.1e-11 44.4 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 EXF77130.1 - 0.0099 15.2 0.2 0.015 14.6 0.2 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain AMP-binding PF00501.28 EXF77131.1 - 9.2e-72 241.9 0.0 1.5e-54 185.2 0.0 2.0 2 0 0 2 2 2 2 AMP-binding enzyme AMP-binding_C PF13193.6 EXF77131.1 - 5e-15 56.2 0.1 9.8e-15 55.3 0.1 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Vhr1 PF04001.13 EXF77131.1 - 0.13 12.5 0.0 0.33 11.3 0.0 1.6 1 0 0 1 1 1 0 Transcription factor Vhr1 AA_permease_2 PF13520.6 EXF77132.1 - 1e-53 182.7 46.9 1.4e-53 182.2 46.8 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EXF77132.1 - 6.2e-20 71.2 37.8 8.4e-20 70.8 37.8 1.0 1 0 0 1 1 1 1 Amino acid permease DUF3493 PF11998.8 EXF77132.1 - 0.046 13.9 0.6 0.15 12.2 0.0 2.2 2 0 0 2 2 2 0 Low psii accumulation1 / Rep27 DUF1182 PF06681.13 EXF77132.1 - 3.5 7.2 10.9 0.069 12.7 1.7 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF1182) Cu_amine_oxid PF01179.20 EXF77133.1 - 2.9e-157 523.8 0.0 3.6e-157 523.5 0.0 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN3 PF02728.16 EXF77133.1 - 4e-18 65.7 0.0 1.2e-17 64.2 0.0 1.8 1 0 0 1 1 1 1 Copper amine oxidase, N3 domain Cu_amine_oxidN2 PF02727.16 EXF77133.1 - 2.7e-10 40.3 0.0 5.4e-10 39.4 0.0 1.5 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain Spc7 PF08317.11 EXF77134.1 - 1.7e-10 40.3 183.5 0.0061 15.5 18.3 7.8 1 1 8 9 9 9 8 Spc7 kinetochore protein Rab5-bind PF09311.11 EXF77134.1 - 8.3e-07 28.7 146.2 7.7e-05 22.2 11.4 9.6 1 1 8 9 9 9 6 Rabaptin-like protein HMMR_N PF15905.5 EXF77134.1 - 1.9e-06 27.6 172.2 0.011 15.3 30.2 7.4 2 2 4 6 6 6 4 Hyaluronan mediated motility receptor N-terminal TPR_MLP1_2 PF07926.12 EXF77134.1 - 0.0068 16.5 26.6 0.0068 16.5 26.6 11.1 1 1 8 11 11 11 4 TPR/MLP1/MLP2-like protein FliJ PF02050.16 EXF77134.1 - 0.014 15.6 1.3 0.014 15.6 1.3 11.1 2 2 11 13 13 13 0 Flagellar FliJ protein Tup_N PF08581.10 EXF77134.1 - 0.084 13.2 107.4 0.052 13.8 3.9 14.6 3 2 11 15 15 15 0 Tup N-terminal DUF3584 PF12128.8 EXF77134.1 - 0.43 8.0 180.6 3.7 4.9 55.9 4.0 1 1 2 3 3 3 0 Protein of unknown function (DUF3584) Pox_A_type_inc PF04508.12 EXF77134.1 - 2.9 7.9 8.6 39 4.3 0.4 5.1 4 0 0 4 4 4 0 Viral A-type inclusion protein repeat Filament PF00038.21 EXF77134.1 - 8.5 5.9 156.5 0.31 10.6 50.2 8.1 1 1 5 7 7 7 0 Intermediate filament protein YceG PF02618.16 EXF77138.1 - 0.067 12.7 0.0 0.067 12.7 0.0 1.6 2 0 0 2 2 2 0 YceG-like family Fungal_trans_2 PF11951.8 EXF77139.1 - 2.3e-09 36.6 0.0 1.7e-06 27.1 0.0 2.3 2 0 0 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF77139.1 - 2.7e-07 30.6 15.5 4.8e-07 29.8 15.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Zn_clus PF00172.18 EXF77140.1 - 1.8e-08 34.4 7.0 2.9e-08 33.7 7.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Synaptobrevin PF00957.21 EXF77140.1 - 0.082 12.7 0.1 0.17 11.7 0.1 1.5 1 0 0 1 1 1 0 Synaptobrevin ADH_N PF08240.12 EXF77141.1 - 1.8e-05 24.6 0.1 0.00015 21.6 0.0 2.0 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain Carb_anhydrase PF00194.21 EXF77143.1 - 9.1e-28 97.5 0.0 5e-13 49.2 0.0 2.1 2 0 0 2 2 2 2 Eukaryotic-type carbonic anhydrase Mucin-like PF16058.5 EXF77145.1 - 0.052 13.6 0.5 0.08 13.0 0.5 1.3 1 0 0 1 1 1 0 Mucin-like KR PF08659.10 EXF77146.1 - 0.012 15.5 0.0 0.091 12.7 0.0 2.0 2 0 0 2 2 2 0 KR domain adh_short PF00106.25 EXF77146.1 - 0.015 14.8 0.0 0.46 9.9 0.0 2.1 2 0 0 2 2 2 0 short chain dehydrogenase RsgA_GTPase PF03193.16 EXF77146.1 - 0.08 12.8 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 RsgA GTPase Pkinase PF00069.25 EXF77147.1 - 1.7e-67 227.6 0.0 3.1e-67 226.7 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF77147.1 - 3e-37 128.3 0.0 5.4e-37 127.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EXF77147.1 - 2.9e-05 23.5 0.0 5.9e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 Kinase-like NOG1_N PF17835.1 EXF77147.1 - 0.0049 16.8 4.3 0.011 15.7 0.2 3.1 3 0 0 3 3 3 1 NOG1 N-terminal helical domain Pkinase_fungal PF17667.1 EXF77147.1 - 0.0064 15.3 0.0 0.014 14.1 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EXF77147.1 - 0.013 15.4 0.0 0.042 13.8 0.0 1.8 1 0 0 1 1 1 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 EXF77147.1 - 0.069 12.2 0.0 0.13 11.3 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 Syntaxin-6_N PF09177.11 EXF77147.1 - 0.22 12.1 0.1 0.22 12.1 0.1 2.8 3 0 0 3 3 3 0 Syntaxin 6, N-terminal Peptidase_S66 PF02016.15 EXF77148.1 - 3.4e-26 91.7 0.0 5.8e-26 91.0 0.0 1.4 1 0 0 1 1 1 1 LD-carboxypeptidase N-terminal domain Peptidase_S66C PF17676.1 EXF77148.1 - 2.4e-24 86.2 0.0 3.7e-24 85.6 0.0 1.3 1 0 0 1 1 1 1 LD-carboxypeptidase C-terminal domain Glycos_transf_2 PF00535.26 EXF77150.1 - 1.5e-26 93.2 0.0 2.6e-26 92.4 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 EXF77150.1 - 1.2e-22 80.9 0.0 2e-22 80.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 EXF77150.1 - 2.2e-11 44.0 2.1 4.3e-11 43.1 2.1 1.4 1 0 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_transf_21 PF13506.6 EXF77150.1 - 2.7e-10 40.0 0.0 5.4e-10 39.0 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 21 Chitin_synth_2 PF03142.15 EXF77150.1 - 2e-08 33.3 0.0 0.0004 19.1 0.0 3.0 2 1 0 2 2 2 2 Chitin synthase Polysacc_deac_1 PF01522.21 EXF77150.1 - 0.00012 22.0 0.0 0.00053 19.9 0.0 2.1 2 0 0 2 2 2 1 Polysaccharide deacetylase Glyco_tranf_2_4 PF13704.6 EXF77150.1 - 0.024 15.1 0.1 0.054 14.0 0.1 1.6 1 0 0 1 1 1 0 Glycosyl transferase family 2 Glyco_tranf_2_2 PF10111.9 EXF77150.1 - 0.06 12.8 0.0 0.1 12.1 0.0 1.3 1 0 0 1 1 1 0 Glycosyltransferase like family 2 MiAMP1 PF09117.10 EXF77151.1 - 0.0073 16.5 3.9 0.025 14.8 1.4 2.1 1 1 1 2 2 2 2 MiAMP1 COesterase PF00135.28 EXF77152.1 - 5.3e-75 253.2 0.0 1e-74 252.3 0.0 1.3 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EXF77152.1 - 0.00014 21.8 0.6 0.0013 18.6 0.6 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Homeodomain PF00046.29 EXF77153.1 - 1.2e-12 47.5 3.5 2.4e-12 46.5 3.5 1.5 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EXF77153.1 - 0.0028 17.5 1.1 0.0071 16.2 1.1 1.7 1 0 0 1 1 1 1 Homeobox KN domain SPARC_Ca_bdg PF10591.9 EXF77153.1 - 0.35 11.2 2.0 0.82 10.0 2.0 1.6 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region V_ATPase_I PF01496.19 EXF77153.1 - 0.38 8.6 3.6 0.52 8.2 3.6 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family NARP1 PF12569.8 EXF77153.1 - 0.87 8.4 9.2 1.3 7.8 9.2 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 HAD_2 PF13419.6 EXF77154.1 - 3e-20 73.1 0.0 3.9e-20 72.7 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EXF77154.1 - 1.8e-09 38.2 0.1 0.0001 22.7 0.0 2.2 1 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 EXF77154.1 - 4.4e-06 27.2 0.0 5.7e-06 26.9 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EXF77154.1 - 3.4e-05 23.8 0.0 5.9e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like GHL6 PF14871.6 EXF77154.1 - 0.017 15.3 0.0 0.041 14.0 0.0 1.6 1 0 0 1 1 1 0 Hypothetical glycosyl hydrolase 6 Hydrolase_6 PF13344.6 EXF77154.1 - 0.034 14.3 0.0 13 6.0 0.0 2.6 3 0 0 3 3 3 0 Haloacid dehalogenase-like hydrolase GN3L_Grn1 PF08701.11 EXF77155.1 - 5e-25 87.4 20.4 9.3e-25 86.5 20.4 1.5 1 0 0 1 1 1 1 GNL3L/Grn1 putative GTPase MMR_HSR1 PF01926.23 EXF77155.1 - 2.8e-17 62.8 0.2 7.6e-13 48.5 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EXF77155.1 - 3.9e-08 33.4 0.1 3.2e-07 30.4 0.1 2.2 1 1 0 1 1 1 1 RsgA GTPase Dynamin_N PF00350.23 EXF77155.1 - 1e-05 25.7 7.8 0.036 14.1 0.5 3.9 4 0 0 4 4 4 2 Dynamin family GTP_EFTU PF00009.27 EXF77155.1 - 1.1e-05 25.0 0.0 0.031 13.8 0.0 2.5 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 EXF77155.1 - 0.00084 18.9 0.3 0.016 14.8 0.1 2.5 2 1 0 2 2 2 1 Ferrous iron transport protein B Nuc_deoxyri_tr2 PF15891.5 EXF77155.1 - 0.008 16.5 0.8 0.58 10.5 0.0 2.7 2 0 0 2 2 2 1 Nucleoside 2-deoxyribosyltransferase like MeaB PF03308.16 EXF77155.1 - 0.032 13.2 4.5 0.081 11.9 0.0 2.3 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AIG1 PF04548.16 EXF77155.1 - 0.036 13.4 0.1 0.11 11.8 0.0 1.8 2 0 0 2 2 2 0 AIG1 family Latrophilin PF02354.16 EXF77155.1 - 0.077 12.1 0.9 0.12 11.5 0.9 1.3 1 0 0 1 1 1 0 Latrophilin Cytoplasmic C-terminal region Roc PF08477.13 EXF77155.1 - 0.083 13.1 0.1 8.2 6.7 0.0 2.5 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.6 EXF77155.1 - 0.59 10.5 0.0 0.59 10.5 0.0 3.4 2 1 0 2 2 2 0 AAA ATPase domain BUD22 PF09073.10 EXF77155.1 - 1.9 7.7 20.6 3.1 7.0 20.6 1.3 1 0 0 1 1 1 0 BUD22 RRN3 PF05327.11 EXF77155.1 - 3 6.3 8.3 4.8 5.6 8.3 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 TFIIA PF03153.13 EXF77155.1 - 3.3 7.6 17.3 5.2 7.0 17.3 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SinI PF08671.10 EXF77157.1 - 0.016 15.0 0.3 0.033 14.0 0.3 1.5 1 0 0 1 1 1 0 Anti-repressor SinI RNB PF00773.19 EXF77158.1 - 1.9e-98 329.8 0.1 2.9e-98 329.2 0.1 1.3 1 0 0 1 1 1 1 RNB domain Rrp44_S1 PF17215.3 EXF77158.1 - 2.3e-32 110.8 0.3 7.2e-32 109.2 0.3 1.9 1 0 0 1 1 1 1 S1 domain Rrp44_CSD1 PF17216.3 EXF77158.1 - 3.9e-27 94.8 0.1 1.4e-26 93.0 0.1 1.9 1 1 0 1 1 1 1 Rrp44-like cold shock domain OB_Dis3 PF17849.1 EXF77158.1 - 6.1e-20 71.0 0.0 1.6e-19 69.7 0.0 1.8 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) PIN_4 PF13638.6 EXF77158.1 - 6.4e-12 45.9 0.2 1.7e-11 44.5 0.2 1.8 1 0 0 1 1 1 1 PIN domain CSD2 PF17876.1 EXF77158.1 - 1.4e-07 31.6 1.6 0.0028 17.8 0.0 3.4 4 0 0 4 4 4 2 Cold shock domain Dis3l2_C_term PF17877.1 EXF77158.1 - 0.0081 16.5 0.0 0.033 14.5 0.0 2.0 1 0 0 1 1 1 1 DIS3-like exonuclease 2 C terminal CRC_subunit PF08624.10 EXF77159.1 - 1.1e-51 174.8 0.0 1.6e-51 174.3 0.0 1.2 1 0 0 1 1 1 1 Chromatin remodelling complex Rsc7/Swp82 subunit Peptidase_M41 PF01434.18 EXF77160.1 - 4.9e-69 232.0 0.0 8.3e-69 231.3 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 EXF77160.1 - 6.5e-43 146.3 0.1 3.1e-42 144.1 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EXF77160.1 - 1.2e-12 47.4 0.1 3.3e-12 46.0 0.1 1.8 1 0 0 1 1 1 1 AAA+ lid domain FtsH_ext PF06480.15 EXF77160.1 - 2.8e-11 43.7 0.0 6.4e-11 42.6 0.0 1.6 1 0 0 1 1 1 1 FtsH Extracellular AAA_5 PF07728.14 EXF77160.1 - 0.00086 19.3 0.0 0.0032 17.5 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) TIP49 PF06068.13 EXF77160.1 - 0.0045 16.3 0.0 0.0084 15.4 0.0 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_16 PF13191.6 EXF77160.1 - 0.0049 17.3 0.2 0.32 11.4 0.1 2.8 1 1 0 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 EXF77160.1 - 0.0062 16.3 0.0 0.028 14.2 0.0 2.1 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EXF77160.1 - 0.0064 16.8 0.2 1.5 9.1 0.1 2.9 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.6 EXF77160.1 - 0.019 15.4 0.0 0.67 10.4 0.0 2.9 2 0 0 2 2 2 0 AAA domain AAA_2 PF07724.14 EXF77160.1 - 0.024 14.7 0.0 0.12 12.4 0.0 2.2 1 1 0 1 1 1 0 AAA domain (Cdc48 subfamily) IstB_IS21 PF01695.17 EXF77160.1 - 0.058 13.1 0.0 0.15 11.8 0.0 1.7 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_25 PF13481.6 EXF77160.1 - 0.062 12.9 0.6 0.65 9.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain Fungal_trans PF04082.18 EXF77161.1 - 6.9e-26 90.9 0.1 3e-25 88.8 0.0 2.0 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF77161.1 - 1.1e-10 41.4 12.0 2e-10 40.6 12.0 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain efThoc1 PF11957.8 EXF77161.1 - 0.034 12.8 0.1 0.08 11.6 0.1 1.5 1 0 0 1 1 1 0 THO complex subunit 1 transcription elongation factor ARL17 PF15840.5 EXF77162.1 - 0.06 13.7 0.1 0.17 12.3 0.1 1.8 1 0 0 1 1 1 0 ADP-ribosylation factor-like protein 17 Fmp27_WPPW PF10359.9 EXF77162.1 - 0.12 11.2 0.0 0.17 10.7 0.0 1.1 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain Yip1 PF04893.17 EXF77163.1 - 0.14 11.9 2.5 0.18 11.5 1.7 1.6 1 1 0 1 1 1 0 Yip1 domain Syndecan PF01034.20 EXF77163.1 - 0.2 11.6 0.0 0.38 10.7 0.0 1.3 1 0 0 1 1 1 0 Syndecan domain Gram_pos_anchor PF00746.21 EXF77163.1 - 2 8.4 5.7 1.3 9.0 1.0 2.6 2 0 0 2 2 2 0 LPXTG cell wall anchor motif PCSK9_C1 PF18459.1 EXF77163.1 - 3.8 7.7 6.1 13 6.0 6.1 1.9 1 0 0 1 1 1 0 Proprotein convertase subtilisin-like/kexin type 9 C-terminal domain DUF676 PF05057.14 EXF77164.1 - 5.7e-08 32.5 0.0 1e-07 31.7 0.0 1.3 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_6 PF12697.7 EXF77164.1 - 7.8e-07 29.9 0.1 2e-06 28.6 0.1 1.8 1 0 0 1 1 1 1 Alpha/beta hydrolase family PGAP1 PF07819.13 EXF77164.1 - 7.9e-07 29.0 0.2 2e-05 24.4 0.2 2.3 1 1 0 1 1 1 1 PGAP1-like protein UPF0227 PF05728.12 EXF77164.1 - 0.0013 18.7 0.0 0.0028 17.6 0.0 1.5 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0227) Hydrolase_4 PF12146.8 EXF77164.1 - 0.0015 17.8 0.1 0.004 16.5 0.0 1.7 2 0 0 2 2 2 1 Serine aminopeptidase, S33 DUF2974 PF11187.8 EXF77164.1 - 0.0073 15.9 0.0 0.015 14.9 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2974) Thioesterase PF00975.20 EXF77164.1 - 0.0076 16.4 0.0 0.0076 16.4 0.0 2.1 2 1 0 2 2 1 1 Thioesterase domain Lipase_3 PF01764.25 EXF77164.1 - 0.012 15.4 0.0 0.024 14.5 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) Abhydrolase_3 PF07859.13 EXF77164.1 - 0.025 14.4 0.0 0.053 13.4 0.0 1.6 1 0 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_1 PF00561.20 EXF77164.1 - 0.032 13.9 0.2 0.086 12.5 0.2 1.8 1 1 0 1 1 1 0 alpha/beta hydrolase fold LIDHydrolase PF10230.9 EXF77164.1 - 0.097 12.2 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase Rox3 PF08633.10 EXF77165.1 - 1.5e-63 214.8 0.3 1.5e-63 214.8 0.3 1.4 2 0 0 2 2 2 1 Rox3 mediator complex subunit PI3_PI4_kinase PF00454.27 EXF77166.1 - 3.4e-44 151.5 0.0 6.5e-44 150.6 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase SNF2_N PF00176.23 EXF77168.1 - 7.4e-73 245.3 0.1 2e-72 243.9 0.0 1.6 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EXF77168.1 - 3.5e-13 49.9 0.0 9.8e-13 48.4 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-RING_5 PF14634.6 EXF77168.1 - 1.2e-07 31.6 2.0 2.1e-07 30.8 2.0 1.4 1 0 0 1 1 1 1 zinc-RING finger domain ResIII PF04851.15 EXF77168.1 - 0.00039 20.5 0.0 0.0016 18.5 0.0 2.0 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit Prok-RING_4 PF14447.6 EXF77168.1 - 0.00088 19.1 2.3 0.0035 17.2 2.5 1.9 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 EXF77168.1 - 0.019 14.8 1.5 0.065 13.1 1.5 1.9 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EXF77168.1 - 0.032 14.6 2.1 0.068 13.5 2.1 1.6 1 0 0 1 1 1 0 Ring finger domain zf-C3HC4_3 PF13920.6 EXF77168.1 - 0.089 12.7 3.4 0.083 12.8 0.9 2.0 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EXF77168.1 - 0.35 10.8 2.7 1.5 8.8 0.2 2.5 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EXF77168.1 - 3.5 7.7 5.4 0.55 10.3 0.4 2.1 2 0 0 2 2 2 0 RING-type zinc-finger Cyt-b5 PF00173.28 EXF77169.1 - 1.3e-17 63.7 0.0 3.2e-17 62.4 0.0 1.7 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain FA_desaturase PF00487.24 EXF77169.1 - 1.7e-17 64.1 14.4 1.7e-17 64.1 14.4 1.6 1 1 0 1 1 1 1 Fatty acid desaturase MCM PF00493.23 EXF77170.1 - 1e-105 351.8 0.2 7.3e-105 349.0 0.0 2.0 2 0 0 2 2 2 1 MCM P-loop domain MCM_OB PF17207.3 EXF77170.1 - 1.1e-36 125.4 0.1 2.1e-36 124.5 0.1 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EXF77170.1 - 1.4e-27 95.9 1.7 3.5e-27 94.7 1.7 1.7 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 EXF77170.1 - 1.5e-16 60.8 1.3 3.8e-16 59.6 1.3 1.7 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 EXF77170.1 - 1.6e-06 27.7 0.0 0.00023 20.6 0.0 2.4 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EXF77170.1 - 1.9e-05 24.7 0.0 4.5e-05 23.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 EXF77170.1 - 0.00045 20.1 0.0 0.0018 18.1 0.0 2.0 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EXF77170.1 - 0.057 13.1 0.0 1.2 8.9 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain DNA_RNApol_7kD PF03604.13 EXF77170.1 - 0.17 11.6 0.6 15 5.4 0.0 2.6 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit Vps54 PF07928.12 EXF77171.1 - 1.6e-52 177.5 1.6 1.4e-51 174.5 0.0 3.1 4 0 0 4 4 4 1 Vps54-like protein Vps54_N PF10475.9 EXF77171.1 - 4.5e-06 26.2 0.8 1.2e-05 24.8 0.8 1.6 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex DUF2451 PF10474.9 EXF77171.1 - 0.00011 22.0 0.0 0.00033 20.5 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function C-terminus (DUF2451) Tn7_Tnp_TnsA_C PF08721.11 EXF77171.1 - 0.093 13.4 0.5 50 4.6 0.1 4.5 4 0 0 4 4 4 0 TnsA endonuclease C terminal Sec8_exocyst PF04048.14 EXF77171.1 - 0.12 12.3 0.4 0.69 9.8 0.2 2.4 2 0 0 2 2 2 0 Sec8 exocyst complex component specific domain DUF296 PF03479.15 EXF77171.1 - 0.12 12.7 0.0 0.5 10.8 0.0 2.0 2 0 0 2 2 2 0 Plants and Prokaryotes Conserved (PCC) domain COG5 PF10392.9 EXF77171.1 - 0.48 10.6 5.4 16 5.7 1.3 2.9 2 0 0 2 2 2 0 Golgi transport complex subunit 5 COG2 PF06148.11 EXF77171.1 - 1.7 8.7 5.2 0.54 10.3 0.9 2.4 3 0 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 F-box-like PF12937.7 EXF77174.1 - 2.7e-09 36.8 4.0 1.8e-08 34.1 4.0 2.4 1 1 0 1 1 1 1 F-box-like F-box PF00646.33 EXF77174.1 - 0.0034 17.2 6.3 0.0041 17.0 2.2 2.7 2 1 0 2 2 2 1 F-box domain Glycogen_syn PF05693.13 EXF77175.1 - 0 1174.5 0.0 0 1174.2 0.0 1.0 1 0 0 1 1 1 1 Glycogen synthase Glyco_transf_4 PF13439.6 EXF77175.1 - 9.6e-06 25.7 0.4 2e-05 24.6 0.4 1.7 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_transf_5 PF08323.11 EXF77175.1 - 3.7e-05 23.5 0.1 7.3e-05 22.6 0.1 1.5 1 0 0 1 1 1 1 Starch synthase catalytic domain Glyco_trans_4_4 PF13579.6 EXF77175.1 - 6.4e-05 23.5 0.1 0.00015 22.3 0.1 1.6 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glycos_transf_1 PF00534.20 EXF77175.1 - 0.00018 21.1 0.0 0.028 13.9 0.0 2.3 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EXF77175.1 - 0.00067 20.1 0.0 0.48 10.9 0.0 2.4 2 0 0 2 2 2 2 Glycosyl transferases group 1 Pkinase PF00069.25 EXF77176.1 - 8.1e-67 225.3 0.0 1.1e-66 224.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF77176.1 - 9.1e-36 123.5 0.0 1.7e-35 122.5 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EXF77176.1 - 0.00053 19.4 0.0 0.00086 18.7 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EXF77176.1 - 0.0036 16.7 0.1 0.0089 15.4 0.1 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 EXF77176.1 - 0.072 12.7 0.0 0.17 11.4 0.0 1.6 1 0 0 1 1 1 0 RIO1 family Haspin_kinase PF12330.8 EXF77176.1 - 0.11 11.4 0.1 0.18 10.7 0.1 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Pkinase_fungal PF17667.1 EXF77176.1 - 0.22 10.3 0.0 0.22 10.3 0.0 3.4 4 1 0 4 4 4 0 Fungal protein kinase Pmp3 PF01679.17 EXF77178.1 - 1.2e-19 70.2 7.6 1.5e-19 69.9 7.6 1.1 1 0 0 1 1 1 1 Proteolipid membrane potential modulator NapE PF06796.11 EXF77178.1 - 0.73 9.4 2.6 1.1 8.9 2.6 1.3 1 0 0 1 1 1 0 Periplasmic nitrate reductase protein NapE zf-RanBP PF00641.18 EXF77179.1 - 2.5e-18 65.1 13.3 8.6e-11 41.0 1.6 2.3 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others RRM_1 PF00076.22 EXF77179.1 - 5.2e-08 32.6 0.0 1e-07 31.6 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNase_T PF00929.24 EXF77179.1 - 1.7e-06 28.6 0.0 2.7e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 Exonuclease CAF1C_H4-bd PF12265.8 EXF77180.1 - 1.4e-26 92.5 0.2 1.5e-25 89.2 0.2 2.7 3 0 0 3 3 3 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 EXF77180.1 - 3.4e-26 91.0 4.9 3.5e-06 27.7 0.1 6.2 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EXF77180.1 - 6e-06 26.5 0.8 0.15 12.3 0.1 4.2 2 1 4 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Leader_Erm PF08253.11 EXF77180.1 - 0.4 11.0 1.0 3.2 8.3 0.4 2.4 2 0 0 2 2 2 0 Erm Leader peptide XRN_M PF17846.1 EXF77181.1 - 9.1e-98 328.1 3.0 1.6e-97 327.3 3.0 1.3 1 0 0 1 1 1 1 Xrn1 helical domain XRN_N PF03159.18 EXF77181.1 - 1.7e-96 322.3 0.0 2.6e-96 321.7 0.0 1.3 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus XRN1_D1 PF18332.1 EXF77181.1 - 7.9e-70 234.5 0.0 1.5e-69 233.6 0.0 1.5 1 0 0 1 1 1 1 Exoribonuclease Xrn1 D1 domain XRN1_D2_D3 PF18334.1 EXF77181.1 - 8.7e-35 118.8 0.0 2.4e-34 117.4 0.0 1.8 1 0 0 1 1 1 1 Exoribonuclease Xrn1 D2/D3 domain SH3_12 PF18129.1 EXF77181.1 - 2e-22 79.0 0.1 4.2e-22 78.0 0.1 1.6 1 0 0 1 1 1 1 Xrn1 SH3-like domain Xrn1_D3 PF18194.1 EXF77181.1 - 1.7e-06 28.0 0.0 3.9e-06 26.9 0.0 1.6 1 0 0 1 1 1 1 Exoribonuclease 1 Domain-3 SPC22 PF04573.12 EXF77182.1 - 6.1e-40 136.5 2.1 7.8e-39 132.9 2.1 1.9 1 1 0 1 1 1 1 Signal peptidase subunit Phage_ABA_S PF18066.1 EXF77182.1 - 0.062 14.0 0.0 0.14 12.8 0.0 1.6 1 0 0 1 1 1 0 Phage ABA sandwich domain Peptidase_C48 PF02902.19 EXF77183.1 - 4.5e-29 101.9 0.0 8.5e-29 100.9 0.0 1.4 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain WD40 PF00400.32 EXF77184.1 - 1.6e-24 85.6 2.0 4.7e-06 27.2 0.0 5.7 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EXF77184.1 - 0.00042 20.6 0.0 0.13 12.6 0.0 3.0 2 1 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EXF77184.1 - 0.021 14.1 0.0 0.17 11.1 0.0 2.3 3 1 0 4 4 4 0 WD40-like domain Nha1_C PF08619.10 EXF77184.1 - 0.052 12.8 11.1 0.092 11.9 11.1 1.3 1 0 0 1 1 1 0 Alkali metal cation/H+ antiporter Nha1 C terminus Proteasome PF00227.26 EXF77185.1 - 2.2e-34 118.6 0.0 2.8e-34 118.3 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit DEAD PF00270.29 EXF77186.1 - 8.1e-49 165.8 0.0 2.5e-48 164.2 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EXF77186.1 - 1.2e-31 109.3 0.0 3.4e-31 107.9 0.0 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EXF77186.1 - 0.0033 17.4 0.0 0.006 16.6 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 EXF77186.1 - 0.025 13.9 0.0 0.043 13.1 0.0 1.3 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit ABC_membrane PF00664.23 EXF77188.1 - 5.1e-54 183.8 35.8 2.7e-33 115.8 16.4 3.2 3 0 0 3 3 3 3 ABC transporter transmembrane region ABC_tran PF00005.27 EXF77188.1 - 1.3e-47 161.7 0.0 3.1e-27 95.8 0.0 2.8 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EXF77188.1 - 8.9e-06 25.3 0.3 0.48 9.8 0.2 3.5 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 EXF77188.1 - 1e-05 26.0 0.0 0.21 12.0 0.0 2.8 2 0 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 EXF77188.1 - 1.8e-05 24.7 1.1 0.0099 15.8 0.1 2.5 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EXF77188.1 - 4.2e-05 23.6 1.7 0.054 13.6 0.1 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase Zeta_toxin PF06414.12 EXF77188.1 - 5.9e-05 22.4 0.0 0.0062 15.8 0.0 2.3 2 0 0 2 2 2 1 Zeta toxin AAA_29 PF13555.6 EXF77188.1 - 0.00036 20.2 1.4 0.44 10.3 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_30 PF13604.6 EXF77188.1 - 0.001 18.8 1.4 0.47 10.1 0.1 2.6 2 0 0 2 2 2 2 AAA domain AAA_23 PF13476.6 EXF77188.1 - 0.0011 19.6 4.7 0.32 11.5 0.0 3.3 3 0 0 3 3 3 2 AAA domain AAA_21 PF13304.6 EXF77188.1 - 0.0016 18.3 0.5 1.7 8.4 0.1 2.8 3 0 0 3 3 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 EXF77188.1 - 0.0037 17.5 1.0 3.7 7.8 0.1 3.1 2 1 0 2 2 2 1 AAA domain TrwB_AAD_bind PF10412.9 EXF77188.1 - 0.005 15.8 0.4 0.66 8.8 0.0 2.5 2 0 0 2 2 2 1 Type IV secretion-system coupling protein DNA-binding domain DUF87 PF01935.17 EXF77188.1 - 0.0068 16.5 2.3 0.14 12.2 0.4 2.3 2 0 0 2 2 2 1 Helicase HerA, central domain Roc PF08477.13 EXF77188.1 - 0.028 14.6 0.2 6.3 7.0 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_28 PF13521.6 EXF77188.1 - 0.03 14.5 1.1 0.13 12.5 0.0 2.5 3 0 0 3 3 2 0 AAA domain AAA_15 PF13175.6 EXF77188.1 - 0.039 13.7 0.2 0.84 9.3 0.1 2.5 2 0 0 2 2 2 0 AAA ATPase domain AAA_7 PF12775.7 EXF77188.1 - 0.042 13.4 0.9 2.1 7.8 0.1 2.5 2 0 0 2 2 2 0 P-loop containing dynein motor region NACHT PF05729.12 EXF77188.1 - 0.046 13.6 0.5 0.38 10.6 0.0 2.4 2 0 0 2 2 2 0 NACHT domain Dynamin_N PF00350.23 EXF77188.1 - 0.054 13.5 3.2 0.66 10.0 0.2 2.6 2 0 0 2 2 2 0 Dynamin family MeaB PF03308.16 EXF77188.1 - 0.061 12.3 1.7 0.58 9.1 0.2 2.3 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB FtsK_SpoIIIE PF01580.18 EXF77188.1 - 0.072 12.4 0.0 7.3 5.9 0.0 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family SRP54 PF00448.22 EXF77188.1 - 0.084 12.5 0.7 0.67 9.6 0.1 2.5 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_18 PF13238.6 EXF77188.1 - 0.1 13.1 0.0 7.3 7.1 0.0 2.7 2 0 0 2 2 2 0 AAA domain ATP_bind_1 PF03029.17 EXF77188.1 - 0.55 10.0 2.2 13 5.4 0.3 2.6 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein NB-ARC PF00931.22 EXF77188.1 - 0.93 8.6 2.4 14 4.8 0.6 2.3 2 0 0 2 2 2 0 NB-ARC domain cobW PF02492.19 EXF77188.1 - 1.8 8.2 3.6 2 8.0 0.4 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Fcf1 PF04900.12 EXF77190.1 - 6.4e-33 113.1 0.2 1.7e-32 111.8 0.1 1.7 2 0 0 2 2 2 1 Fcf1 PIN_9 PF18477.1 EXF77190.1 - 6.5e-11 42.6 0.0 2.8e-10 40.5 0.0 1.9 2 0 0 2 2 2 1 PIN like domain GCV_T PF01571.21 EXF77190.1 - 0.078 12.3 0.0 0.12 11.7 0.0 1.2 1 0 0 1 1 1 0 Aminomethyltransferase folate-binding domain Fungal_trans PF04082.18 EXF77191.1 - 3.3e-15 55.8 0.3 2.5e-14 53.0 0.3 2.1 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF77191.1 - 4.1e-05 23.6 10.4 7.2e-05 22.8 10.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain NmrA PF05368.13 EXF77192.1 - 3.9e-80 268.8 0.0 5.3e-80 268.3 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EXF77192.1 - 2e-07 31.1 0.5 7.7e-06 25.9 0.2 2.5 2 1 0 2 2 2 1 NAD(P)H-binding DUF3798 PF12683.7 EXF77192.1 - 0.17 11.3 0.0 0.26 10.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3798) DUF755 PF05501.11 EXF77192.1 - 0.3 11.4 5.7 0.51 10.6 5.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF755) Xpo1 PF08389.12 EXF77193.1 - 4.8e-37 127.3 4.0 6.9e-37 126.8 0.1 3.3 3 1 0 3 3 3 1 Exportin 1-like protein HEAT PF02985.22 EXF77193.1 - 0.004 17.3 0.0 13 6.4 0.0 4.0 3 0 0 3 3 3 2 HEAT repeat HNOB PF07700.15 EXF77193.1 - 0.018 15.0 0.3 0.94 9.4 0.0 3.3 3 1 1 4 4 4 0 Haem-NO-binding DUF2347 PF09804.9 EXF77194.1 - 2.7e-109 365.1 0.0 3.5e-109 364.8 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2347) DUF4484 PF14831.6 EXF77194.1 - 1.1e-61 208.6 4.3 1.1e-61 208.6 4.3 2.7 2 1 0 2 2 2 1 Domain of unknown function (DUF4484) SPA PF08616.10 EXF77194.1 - 0.00024 21.1 0.0 0.00056 19.9 0.0 1.5 1 1 0 1 1 1 1 Stabilization of polarity axis Importin_rep_4 PF18808.1 EXF77194.1 - 0.014 15.7 2.7 0.017 15.4 1.4 1.8 2 0 0 2 2 2 0 Importin repeat Acyltransferase PF01553.21 EXF77195.1 - 8.1e-33 112.9 0.0 1.4e-32 112.2 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase Ribonuc_L-PSP PF01042.21 EXF77195.1 - 0.04 13.9 0.0 0.13 12.3 0.0 1.7 2 0 0 2 2 2 0 Endoribonuclease L-PSP Lip_A_acyltrans PF03279.13 EXF77195.1 - 0.076 12.2 0.0 0.096 11.8 0.0 1.2 1 0 0 1 1 1 0 Bacterial lipid A biosynthesis acyltransferase DUF3336 PF11815.8 EXF77196.1 - 1e-52 177.5 2.4 1.7e-52 176.8 2.4 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Patatin PF01734.22 EXF77196.1 - 3e-19 70.0 0.9 1.6e-18 67.6 0.0 2.6 3 1 0 3 3 3 1 Patatin-like phospholipase Arf PF00025.21 EXF77197.1 - 3.3e-66 222.0 0.0 3.7e-66 221.9 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 EXF77197.1 - 4.5e-11 42.5 0.0 1.8e-07 30.7 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 EXF77197.1 - 7e-08 32.1 0.0 9.1e-08 31.7 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 EXF77197.1 - 1.2e-07 31.5 0.0 1.6e-07 31.1 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EXF77197.1 - 1.3e-07 31.9 0.0 4.1e-07 30.2 0.0 1.7 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 EXF77197.1 - 3.3e-07 30.4 0.0 4.4e-07 30.0 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EXF77197.1 - 1.2e-05 24.8 0.0 1.4e-05 24.6 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EXF77197.1 - 0.0016 18.0 0.0 0.062 12.8 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain DUF2457 PF10446.9 EXF77198.1 - 2.1e-126 422.8 19.6 2.1e-126 422.8 19.6 3.6 2 1 2 4 4 4 1 Protein of unknown function (DUF2457) F-box-like PF12937.7 EXF77200.1 - 6.2e-11 42.0 0.1 6.2e-11 42.0 0.1 2.4 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EXF77200.1 - 1e-07 31.6 0.6 2.2e-07 30.6 0.0 1.8 2 0 0 2 2 2 1 F-box domain LRR_4 PF12799.7 EXF77200.1 - 0.00066 20.0 2.1 2 9.0 0.6 3.6 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) TPR_1 PF00515.28 EXF77200.1 - 0.0025 17.6 0.5 1.7 8.6 0.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 EXF77200.1 - 0.058 13.5 6.2 3.7 7.9 0.1 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 EXF77200.1 - 0.15 13.0 0.6 0.68 10.9 0.6 2.2 1 0 0 1 1 1 0 Tetratricopeptide repeat ADIP PF11559.8 EXF77201.1 - 5e-41 140.3 6.0 5e-41 140.3 6.0 2.2 2 0 0 2 2 2 1 Afadin- and alpha -actinin-Binding Golgin_A5 PF09787.9 EXF77201.1 - 0.00088 18.8 2.4 0.0034 16.9 2.4 2.0 1 0 0 1 1 1 1 Golgin subfamily A member 5 DUF4686 PF15742.5 EXF77201.1 - 0.0015 17.8 1.1 0.0034 16.6 1.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4686) DUF3584 PF12128.8 EXF77201.1 - 0.019 12.5 5.7 0.032 11.8 5.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF641 PF04859.12 EXF77201.1 - 0.038 14.3 5.3 0.54 10.6 1.4 3.2 2 1 1 3 3 3 0 Plant protein of unknown function (DUF641) DegS PF05384.11 EXF77201.1 - 0.055 13.0 5.1 0.14 11.6 5.1 1.7 1 0 0 1 1 1 0 Sensor protein DegS Spc7 PF08317.11 EXF77201.1 - 0.83 8.5 8.8 0.26 10.1 5.5 1.8 2 0 0 2 2 2 0 Spc7 kinetochore protein Macoilin PF09726.9 EXF77201.1 - 1 7.8 13.6 0.67 8.4 9.0 2.1 2 0 0 2 2 2 0 Macoilin family AdoMet_MTase PF07757.13 EXF77202.1 - 1.2e-38 131.9 0.0 1.8e-38 131.3 0.0 1.3 1 0 0 1 1 1 1 Predicted AdoMet-dependent methyltransferase Methyltransf_23 PF13489.6 EXF77202.1 - 0.031 14.1 0.0 0.063 13.1 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_32 PF13679.6 EXF77202.1 - 0.068 13.2 0.0 1.8 8.5 0.0 2.4 3 0 0 3 3 3 0 Methyltransferase domain NMO PF03060.15 EXF77203.1 - 8.8e-32 110.8 13.6 5.7e-31 108.1 13.6 2.0 1 1 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.25 EXF77203.1 - 5.5e-13 48.6 4.9 9.1e-13 47.9 4.9 1.3 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.18 EXF77203.1 - 2e-06 27.1 9.7 3e-06 26.5 9.7 1.2 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Glu_synthase PF01645.17 EXF77203.1 - 0.00025 20.3 3.9 0.00037 19.7 3.9 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase Aldo_ket_red PF00248.21 EXF77204.1 - 1.1e-69 234.9 0.0 1.2e-69 234.7 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family IDEAL PF08858.10 EXF77204.1 - 0.033 13.9 0.8 0.079 12.7 0.8 1.6 1 0 0 1 1 1 0 IDEAL domain FliG_M PF14841.6 EXF77204.1 - 0.11 12.7 0.2 0.18 12.1 0.2 1.3 1 0 0 1 1 1 0 FliG middle domain CedA PF10729.9 EXF77204.1 - 0.11 12.3 0.0 0.25 11.2 0.0 1.6 1 0 0 1 1 1 0 Cell division activator CedA zf-CCHC PF00098.23 EXF77205.1 - 6.6e-44 146.1 76.2 2.5e-07 30.5 4.1 9.2 9 0 0 9 9 9 9 Zinc knuckle zf-CCHC_3 PF13917.6 EXF77205.1 - 8.8e-11 41.6 51.9 0.0082 16.1 1.0 8.2 2 2 6 8 8 8 7 Zinc knuckle zf-CCHC_2 PF13696.6 EXF77205.1 - 1.1e-08 34.7 73.8 0.00048 19.9 1.5 9.3 10 0 0 10 10 10 7 Zinc knuckle zf-CCHC_4 PF14392.6 EXF77205.1 - 0.00041 20.0 53.6 0.024 14.4 0.8 8.4 9 0 0 9 9 9 5 Zinc knuckle zf-CCHC_6 PF15288.6 EXF77205.1 - 0.012 15.4 3.0 0.012 15.4 3.0 7.8 6 1 2 8 8 8 0 Zinc knuckle Response_reg PF00072.24 EXF77206.1 - 1.1e-27 96.4 0.5 2e-27 95.6 0.5 1.4 1 0 0 1 1 1 1 Response regulator receiver domain HATPase_c PF02518.26 EXF77206.1 - 2.4e-26 92.4 1.6 1.2e-24 86.9 0.1 3.1 2 1 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 EXF77206.1 - 2.7e-14 52.9 0.0 6e-14 51.8 0.0 1.6 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HAMP PF00672.25 EXF77206.1 - 0.011 16.1 0.3 0.059 13.8 0.1 2.3 2 0 0 2 2 2 0 HAMP domain FAM76 PF16046.5 EXF77207.1 - 0.32 10.3 3.3 0.51 9.6 3.3 1.2 1 0 0 1 1 1 0 FAM76 protein Acetyltransf_1 PF00583.25 EXF77210.1 - 3.9e-05 23.9 0.0 6.6e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family CENP-T_C PF15511.6 EXF77211.1 - 3.6e-05 23.8 0.1 5.2e-05 23.3 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CBFD_NFYB_HMF PF00808.23 EXF77211.1 - 0.00063 20.0 0.0 0.001 19.3 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EXF77211.1 - 0.022 15.1 0.1 0.034 14.5 0.1 1.3 1 1 0 1 1 1 0 Core histone H2A/H2B/H3/H4 TFIID-31kDa PF02291.15 EXF77211.1 - 0.064 13.3 0.0 0.078 13.0 0.0 1.2 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit IlvC PF01450.19 EXF77211.1 - 0.14 12.4 0.0 0.17 12.1 0.0 1.2 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, catalytic domain Svf1_C PF17187.4 EXF77212.1 - 2.3e-62 209.7 0.0 1.8e-61 206.8 0.0 2.1 2 0 0 2 2 2 1 Svf1-like C-terminal lipocalin-like domain Svf1 PF08622.10 EXF77212.1 - 4.7e-55 186.1 0.1 7e-55 185.5 0.1 1.3 1 0 0 1 1 1 1 Svf1-like N-terminal lipocalin domain LPD18 PF18832.1 EXF77212.1 - 0.13 12.4 0.0 0.4 10.8 0.0 1.8 2 0 0 2 2 2 0 Large polyvalent protein-associated domain 18 Ribosomal_L11 PF00298.19 EXF77213.1 - 4.3e-29 100.8 0.2 7.1e-29 100.1 0.2 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain Ribosomal_L11_N PF03946.14 EXF77213.1 - 1.5e-25 88.8 0.1 2.5e-25 88.1 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Pkinase PF00069.25 EXF77214.1 - 4.7e-47 160.6 0.0 1.3e-46 159.2 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Cpn10 PF00166.21 EXF77214.1 - 4.1e-27 94.1 0.0 9.4e-27 92.9 0.0 1.7 1 0 0 1 1 1 1 Chaperonin 10 Kd subunit Pkinase_Tyr PF07714.17 EXF77214.1 - 3.9e-21 75.5 0.0 6.6e-21 74.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EXF77214.1 - 0.0063 16.5 0.0 0.012 15.5 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EXF77214.1 - 0.031 13.2 0.0 0.049 12.6 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain DUF3425 PF11905.8 EXF77216.1 - 1.1e-17 64.2 0.4 1.1e-17 64.2 0.4 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF3425) Tma16 PF11176.8 EXF77216.1 - 0.085 12.7 3.3 0.16 11.9 3.3 1.3 1 0 0 1 1 1 0 Translation machinery-associated protein 16 Nse5 PF08691.10 EXF77216.1 - 0.15 10.7 0.0 0.21 10.2 0.0 1.1 1 0 0 1 1 1 0 DNA repair proteins Nse5 and Nse6 bZIP_1 PF00170.21 EXF77216.1 - 0.23 11.6 17.4 0.048 13.8 9.2 2.2 1 1 1 2 2 2 0 bZIP transcription factor FapA PF03961.13 EXF77216.1 - 0.46 9.0 0.9 0.76 8.3 0.6 1.4 2 0 0 2 2 2 0 Flagellar Assembly Protein A Podoplanin PF05808.11 EXF77218.1 - 0.16 12.1 7.9 0.31 11.1 7.9 1.4 1 0 0 1 1 1 0 Podoplanin Dicty_REP PF05086.12 EXF77218.1 - 1.7 6.5 8.6 2.2 6.1 8.6 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein FSA_C PF10479.9 EXF77218.1 - 2.4 6.2 12.2 3.1 5.8 12.2 1.3 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Granulin PF00396.18 EXF77218.1 - 2.4 8.6 29.1 2.9 8.3 4.0 3.5 2 1 1 3 3 3 0 Granulin MAP65_ASE1 PF03999.12 EXF77218.1 - 5.8 5.5 5.9 6.8 5.3 5.9 1.1 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) Promethin PF16015.5 EXF77219.1 - 0.15 12.0 2.0 0.29 11.1 2.0 1.4 1 0 0 1 1 1 0 Promethin Methyltransf_25 PF13649.6 EXF77220.1 - 1.4e-07 32.1 0.0 2.8e-07 31.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EXF77220.1 - 1.5e-07 31.4 0.0 2e-07 31.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF77220.1 - 5e-05 23.9 0.0 9.5e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF77220.1 - 0.00069 19.4 0.0 0.0014 18.4 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF77220.1 - 0.002 18.8 0.0 0.0048 17.6 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EXF77220.1 - 0.0035 16.7 0.0 0.0053 16.1 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family adh_short_C2 PF13561.6 EXF77221.1 - 5.3e-52 176.7 0.3 7.2e-52 176.3 0.3 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF77221.1 - 1.3e-36 126.0 1.0 2.2e-36 125.2 0.4 1.7 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.10 EXF77221.1 - 7.1e-13 48.9 0.5 9e-13 48.5 0.5 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EXF77221.1 - 0.0046 16.5 0.2 0.009 15.5 0.2 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EXF77221.1 - 0.08 12.1 0.0 0.1 11.7 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Fungal_trans PF04082.18 EXF77222.1 - 3e-68 229.8 0.0 4.1e-68 229.3 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 EXF77222.1 - 0.0001 22.6 13.3 0.00031 21.0 0.7 3.2 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EXF77222.1 - 0.015 15.7 1.1 0.015 15.7 1.1 3.2 3 0 0 3 3 3 0 Zinc-finger double domain zf-C2H2_4 PF13894.6 EXF77222.1 - 0.057 14.3 0.7 0.057 14.3 0.7 3.3 3 0 0 3 3 3 0 C2H2-type zinc finger F-box-like PF12937.7 EXF77223.1 - 3.3e-09 36.5 0.0 8.5e-09 35.2 0.0 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EXF77223.1 - 1.5e-06 27.9 0.0 3.2e-06 26.9 0.0 1.6 1 0 0 1 1 1 1 F-box domain DUF3446 PF11928.8 EXF77223.1 - 0.25 11.7 9.8 0.28 11.5 8.3 1.9 2 0 0 2 2 2 0 Early growth response N-terminal domain SR-25 PF10500.9 EXF77223.1 - 0.64 9.6 13.6 0.92 9.1 13.6 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein RAP1 PF07218.11 EXF77223.1 - 4.7 5.4 3.8 6.3 5.0 3.8 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Mito_carr PF00153.27 EXF77224.1 - 5.3e-68 225.0 4.1 1.4e-22 79.4 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 EXF77224.1 - 0.025 13.7 5.9 0.98 8.5 0.3 3.2 1 1 2 3 3 3 0 Gammaproteobacterial serine protease Bac_export_2 PF01312.19 EXF77224.1 - 0.049 12.8 0.0 0.076 12.2 0.0 1.2 1 0 0 1 1 1 0 FlhB HrpN YscU SpaS Family DnaJ PF00226.31 EXF77225.1 - 5.1e-21 74.6 1.9 5.1e-21 74.6 1.9 2.5 3 0 0 3 3 3 1 DnaJ domain TPR_2 PF07719.17 EXF77225.1 - 2.7e-18 64.5 2.1 0.0087 16.1 0.0 8.1 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_1 PF00515.28 EXF77225.1 - 1.3e-16 59.7 0.5 0.00021 21.0 0.0 6.3 8 0 0 8 8 7 4 Tetratricopeptide repeat TPR_8 PF13181.6 EXF77225.1 - 1.7e-13 49.6 0.7 0.0018 18.3 0.0 6.8 8 0 0 8 8 6 3 Tetratricopeptide repeat TPR_14 PF13428.6 EXF77225.1 - 2.8e-13 49.5 6.1 0.026 15.3 0.1 7.3 3 3 5 8 8 8 3 Tetratricopeptide repeat TPR_9 PF13371.6 EXF77225.1 - 3.6e-12 46.2 0.1 0.00061 19.9 0.0 4.5 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_11 PF13414.6 EXF77225.1 - 2.7e-09 36.6 2.6 0.027 14.2 0.1 5.3 4 2 2 6 6 5 3 TPR repeat TPR_19 PF14559.6 EXF77225.1 - 2.1e-08 34.5 5.5 0.021 15.3 0.0 4.9 3 1 2 5 5 4 3 Tetratricopeptide repeat TPR_17 PF13431.6 EXF77225.1 - 2.3e-07 30.7 1.1 0.0008 19.6 0.1 5.4 7 0 0 7 7 5 1 Tetratricopeptide repeat PknG_TPR PF16918.5 EXF77225.1 - 6.5e-07 28.4 0.6 0.0002 20.2 0.2 2.9 2 2 0 3 3 3 2 Protein kinase G tetratricopeptide repeat TPR_7 PF13176.6 EXF77225.1 - 5.7e-06 26.0 4.1 1 9.6 0.0 6.5 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_6 PF13174.6 EXF77225.1 - 6.8e-06 26.4 10.7 3.4 8.5 0.0 7.5 9 0 0 9 9 7 2 Tetratricopeptide repeat TPR_15 PF13429.6 EXF77225.1 - 2e-05 24.0 4.1 3 7.0 0.0 5.3 2 2 3 5 5 5 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EXF77225.1 - 0.00043 20.4 8.5 0.013 15.7 0.0 4.9 4 1 2 6 6 6 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.6 EXF77225.1 - 0.00079 20.0 7.3 0.17 12.6 0.1 4.9 3 1 2 5 5 5 1 Tetratricopeptide repeat TPR_12 PF13424.6 EXF77225.1 - 0.0064 16.8 11.6 0.18 12.2 0.1 5.7 2 2 5 7 7 6 2 Tetratricopeptide repeat TPR_20 PF14561.6 EXF77225.1 - 0.24 11.7 4.5 2.2 8.7 0.0 4.1 2 2 2 4 4 4 0 Tetratricopeptide repeat TPR_10 PF13374.6 EXF77225.1 - 1.5 8.8 8.1 53 3.9 0.0 5.4 6 0 0 6 6 5 0 Tetratricopeptide repeat Troponin PF00992.20 EXF77226.1 - 0.036 14.4 0.4 0.036 14.4 0.4 2.1 2 0 0 2 2 2 0 Troponin SlyX PF04102.12 EXF77226.1 - 0.06 14.0 1.5 4.5 8.0 0.2 3.3 2 1 1 3 3 3 0 SlyX COG2 PF06148.11 EXF77226.1 - 0.064 13.3 2.0 3.7 7.6 0.1 2.6 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF4051 PF13260.6 EXF77226.1 - 0.081 12.7 0.2 0.18 11.6 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4051) DUF4404 PF14357.6 EXF77226.1 - 0.22 12.2 0.2 0.22 12.2 0.2 3.4 2 1 0 3 3 3 0 Domain of unknown function (DUF4404) DivIC PF04977.15 EXF77226.1 - 0.41 10.4 2.1 11 5.9 0.1 3.1 2 1 0 3 3 3 0 Septum formation initiator DUF3322 PF11795.8 EXF77226.1 - 1.2 9.2 8.4 0.16 12.0 0.8 2.6 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria N-term (DUF3322) PspB PF06667.12 EXF77226.1 - 1.9 8.6 6.4 1.7 8.8 0.1 3.4 2 1 1 3 3 3 0 Phage shock protein B FUSC PF04632.12 EXF77226.1 - 3.3 6.1 21.5 1.3 7.5 12.6 2.8 1 1 1 2 2 2 0 Fusaric acid resistance protein family TMF_TATA_bd PF12325.8 EXF77226.1 - 8 6.7 9.7 1.6 9.0 0.0 3.2 3 1 0 3 3 3 0 TATA element modulatory factor 1 TATA binding Vac14_Fig4_bd PF11916.8 EXF77227.1 - 3.7e-61 205.9 14.5 1.1e-48 165.3 7.2 2.7 2 1 1 3 3 3 2 Vacuolar protein 14 C-terminal Fig4p binding Vac14_Fab1_bd PF12755.7 EXF77227.1 - 3.5e-30 104.4 0.2 1.2e-22 80.4 0.0 4.8 4 1 1 5 5 5 2 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 EXF77227.1 - 1.4e-08 35.0 0.1 0.0062 16.6 0.1 3.5 3 0 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 EXF77227.1 - 6.8e-08 32.9 8.4 0.0001 22.7 0.1 5.0 5 0 0 5 5 5 2 HEAT-like repeat HEAT PF02985.22 EXF77227.1 - 1.9e-06 27.6 3.4 0.0014 18.7 0.0 5.3 5 0 0 5 5 5 1 HEAT repeat HEAT_2 PF13646.6 EXF77227.1 - 0.001 19.4 3.1 0.16 12.4 0.1 4.6 4 1 0 4 4 4 1 HEAT repeats Arm PF00514.23 EXF77227.1 - 0.0028 17.6 0.0 0.64 10.1 0.0 4.0 4 0 0 4 4 4 1 Armadillo/beta-catenin-like repeat FA_desaturase PF00487.24 EXF77230.1 - 7.4e-25 88.2 27.5 1.2e-24 87.5 27.5 1.4 1 0 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.28 EXF77230.1 - 5.7e-10 39.2 0.1 1.8e-09 37.6 0.0 1.8 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain Glyco_hydro_17 PF00332.18 EXF77231.1 - 3.8e-06 26.7 2.5 5e-06 26.3 0.2 2.1 2 1 1 3 3 3 1 Glycosyl hydrolases family 17 Aminotran_1_2 PF00155.21 EXF77232.1 - 1.7e-37 129.5 0.0 2.1e-37 129.2 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EXF77232.1 - 2.5e-05 23.0 0.0 7.5e-05 21.4 0.0 1.6 2 0 0 2 2 2 1 Cys/Met metabolism PLP-dependent enzyme OKR_DC_1 PF01276.20 EXF77232.1 - 0.0081 14.9 0.0 0.46 9.2 0.0 2.6 2 1 0 2 2 2 1 Orn/Lys/Arg decarboxylase, major domain SnAPC_2_like PF11035.8 EXF77232.1 - 0.081 13.1 0.2 0.13 12.4 0.2 1.2 1 0 0 1 1 1 0 Small nuclear RNA activating complex subunit 2, SNAP190 Myb Glucan_synthase PF02364.15 EXF77233.1 - 0 1373.5 0.0 0 1372.4 0.0 1.5 2 0 0 2 2 2 1 1,3-beta-glucan synthase component FKS1_dom1 PF14288.6 EXF77233.1 - 9.2e-44 148.9 0.8 3.1e-43 147.2 0.8 2.0 1 1 0 1 1 1 1 1,3-beta-glucan synthase subunit FKS1, domain-1 SprT-like PF10263.9 EXF77234.1 - 1.8e-37 127.7 1.3 1.8e-37 127.7 1.3 2.1 3 0 0 3 3 3 1 SprT-like family Zn_ribbon_SprT PF17283.2 EXF77234.1 - 2.9e-10 39.9 4.0 5.1e-10 39.1 4.0 1.4 1 0 0 1 1 1 1 SprT-like zinc ribbon domain HMG_box PF00505.19 EXF77234.1 - 6e-05 23.4 2.0 9.6e-05 22.7 0.1 2.3 2 0 0 2 2 2 1 HMG (high mobility group) box YABBY PF04690.13 EXF77234.1 - 0.005 17.4 0.5 0.005 17.4 0.5 2.6 3 0 0 3 3 3 1 YABBY protein STOP PF05217.12 EXF77234.1 - 0.028 14.7 0.2 0.091 13.1 0.2 1.9 1 0 0 1 1 1 0 STOP protein Zn-ribbon_8 PF09723.10 EXF77234.1 - 0.053 13.6 1.8 0.13 12.4 1.8 1.6 1 0 0 1 1 1 0 Zinc ribbon domain DUF4379 PF14311.6 EXF77234.1 - 1.9 8.9 7.1 1.3 9.4 3.9 2.4 2 0 0 2 2 2 0 Probable Zinc-ribbon domain Mog1 PF04603.12 EXF77235.1 - 2.6e-38 131.5 0.0 3.1e-38 131.2 0.0 1.1 1 0 0 1 1 1 1 Ran-interacting Mog1 protein HIT PF01230.23 EXF77236.1 - 2.2e-23 82.8 0.1 3.1e-23 82.3 0.1 1.2 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 EXF77236.1 - 7.4e-14 52.2 0.0 1.1e-13 51.6 0.0 1.2 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.15 EXF77236.1 - 2.5e-05 24.1 0.3 4e-05 23.5 0.3 1.4 1 1 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 LppA PF16708.5 EXF77236.1 - 0.02 14.8 0.0 0.029 14.3 0.0 1.2 1 0 0 1 1 1 0 Lipoprotein confined to pathogenic Mycobacterium CRAL_TRIO PF00650.20 EXF77237.1 - 2.6e-41 141.0 0.0 4.3e-41 140.3 0.0 1.4 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EXF77237.1 - 1.6e-14 53.8 2.1 1.8e-14 53.6 0.2 2.1 2 0 0 2 2 2 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 EXF77237.1 - 2e-07 31.2 0.0 3.4e-07 30.5 0.0 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain DASH_Dam1 PF08653.10 EXF77238.1 - 2.5e-26 91.2 2.7 3.7e-26 90.7 2.7 1.3 1 0 0 1 1 1 1 DASH complex subunit Dam1 zf-C2H2_jaz PF12171.8 EXF77239.1 - 2.5e-10 40.4 0.1 3.9e-10 39.7 0.1 1.3 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 EXF77239.1 - 0.057 13.4 0.3 0.095 12.7 0.3 1.4 1 0 0 1 1 1 0 C2H2-type zinc finger Spuma_A9PTase PF03539.14 EXF77239.1 - 0.091 12.9 0.1 0.12 12.5 0.1 1.2 1 0 0 1 1 1 0 Spumavirus aspartic protease (A9) zf-C2H2_2 PF12756.7 EXF77239.1 - 0.11 12.8 0.1 0.18 12.2 0.1 1.4 1 1 0 1 1 1 0 C2H2 type zinc-finger (2 copies) GH-E PF14410.6 EXF77239.1 - 0.12 12.8 0.1 0.28 11.6 0.1 1.6 1 0 0 1 1 1 0 HNH/ENDO VII superfamily nuclease with conserved GHE residues Gaa1 PF04114.14 EXF77240.1 - 1.3e-171 572.0 1.3 1.5e-171 571.8 1.3 1.0 1 0 0 1 1 1 1 Gaa1-like, GPI transamidase component PCI PF01399.27 EXF77241.1 - 1.2e-10 41.9 0.0 2.1e-10 41.0 0.0 1.5 1 0 0 1 1 1 1 PCI domain Rpn9_C PF18261.1 EXF77241.1 - 1.6e-08 34.0 1.8 3.6e-08 32.9 1.8 1.6 1 0 0 1 1 1 1 Rpn9 C-terminal helix Dam PF05869.11 EXF77241.1 - 0.052 13.1 0.0 0.13 11.9 0.0 1.7 2 0 0 2 2 2 0 DNA N-6-adenine-methyltransferase (Dam) NmrA PF05368.13 EXF77242.1 - 3.7e-17 62.7 0.0 5.2e-17 62.2 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EXF77242.1 - 2.4e-14 53.7 0.0 4.2e-14 52.8 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EXF77242.1 - 4.1e-14 52.6 0.1 8.2e-14 51.6 0.1 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EXF77242.1 - 1.3e-10 40.8 0.1 5.7e-10 38.7 0.1 1.8 1 1 1 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 EXF77242.1 - 6.8e-09 35.2 0.0 2.6e-07 30.0 0.0 2.3 1 1 0 1 1 1 1 RmlD substrate binding domain GDP_Man_Dehyd PF16363.5 EXF77242.1 - 9.9e-08 31.7 0.1 1.6e-07 31.0 0.1 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase adh_short PF00106.25 EXF77242.1 - 0.00058 19.4 0.0 0.00086 18.8 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase NAD_binding_4 PF07993.12 EXF77242.1 - 0.0016 17.7 0.5 2.2 7.4 0.0 2.9 1 1 2 3 3 3 2 Male sterility protein KR PF08659.10 EXF77242.1 - 0.018 14.9 0.0 5.9 6.8 0.0 2.3 2 0 0 2 2 2 0 KR domain HIM1 PF08732.10 EXF77242.1 - 0.022 14.3 0.0 0.034 13.6 0.0 1.3 1 0 0 1 1 1 0 HIM1 Polysacc_synt_2 PF02719.15 EXF77242.1 - 0.032 13.4 0.0 0.072 12.2 0.0 1.5 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein adh_short_C2 PF13561.6 EXF77242.1 - 0.074 12.6 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase ApbA PF02558.16 EXF77242.1 - 0.11 12.1 0.0 0.22 11.2 0.0 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA DapB_N PF01113.20 EXF77242.1 - 0.16 12.1 0.0 0.45 10.6 0.0 1.7 1 1 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus N6-adenineMlase PF10237.9 EXF77243.1 - 4.4e-49 166.3 0.0 7.5e-49 165.6 0.0 1.4 1 1 0 1 1 1 1 Probable N6-adenine methyltransferase UCH PF00443.29 EXF77244.1 - 8.4e-49 166.4 3.1 9.5e-49 166.2 1.2 1.8 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EXF77244.1 - 2.8e-29 102.7 4.4 5.9e-29 101.7 4.4 1.5 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 EXF77244.1 - 2.8e-05 24.3 0.3 2.8e-05 24.3 0.3 2.3 2 0 0 2 2 2 1 Zn-finger in ubiquitin-hydrolases and other protein zf-CCHC PF00098.23 EXF77244.1 - 5.8 7.2 10.6 32 4.8 0.0 4.4 4 0 0 4 4 4 0 Zinc knuckle BLACT_WH PF17778.1 EXF77245.1 - 5.7e-19 67.8 0.1 1e-18 67.0 0.1 1.4 1 0 0 1 1 1 1 Beta-lactamase associated winged helix domain Lactamase_B PF00753.27 EXF77245.1 - 1e-16 61.6 1.2 3.4e-14 53.3 1.2 2.2 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EXF77245.1 - 1.7e-06 27.7 0.0 3.9e-06 26.5 0.0 1.6 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 EXF77245.1 - 0.00044 20.2 0.1 0.00068 19.6 0.1 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Ytp1 PF10355.9 EXF77246.1 - 9.8e-121 402.2 5.5 1.4e-120 401.7 5.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (Ytp1) DUF2427 PF10348.9 EXF77246.1 - 1.1e-31 108.7 6.4 1.1e-31 108.7 6.4 3.5 3 0 0 3 3 3 2 Domain of unknown function (DUF2427) DUF5504 PF17608.2 EXF77246.1 - 0.056 13.5 3.6 0.67 10.1 3.3 2.7 2 0 0 2 2 2 0 Family of unknown function (DUF5504) ZYG-11_interact PF05884.12 EXF77246.1 - 0.087 12.2 1.3 0.18 11.2 1.3 1.5 1 0 0 1 1 1 0 Interactor of ZYG-11 Rsa3 PF14615.6 EXF77247.1 - 3.5e-21 74.5 0.2 5e-21 74.0 0.2 1.2 1 0 0 1 1 1 1 Ribosome-assembly protein 3 RNA_polI_A34 PF08208.11 EXF77247.1 - 0.049 13.7 9.5 0.059 13.4 9.5 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 THOC2_N PF16134.5 EXF77247.1 - 0.62 8.6 3.8 0.73 8.4 3.8 1.1 1 0 0 1 1 1 0 THO complex subunit 2 N-terminus DUF4157 PF13699.6 EXF77247.1 - 1.9 8.7 5.3 94 3.3 5.3 2.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4157) CFEM PF05730.11 EXF77248.1 - 4.6e-16 58.7 10.2 5.5e-16 58.4 10.2 1.1 1 0 0 1 1 1 1 CFEM domain CBS PF00571.28 EXF77249.1 - 1.1e-16 61.1 6.5 6.7e-06 26.5 0.0 5.6 5 1 1 6 6 6 4 CBS domain Importin_rep_4 PF18808.1 EXF77250.1 - 3.2e-32 110.7 9.7 1.9e-31 108.2 1.9 4.6 4 1 1 5 5 4 1 Importin repeat HEAT_EZ PF13513.6 EXF77250.1 - 5.3e-22 77.9 14.1 5.6e-11 42.7 0.3 9.1 7 1 2 9 9 8 3 HEAT-like repeat HEAT PF02985.22 EXF77250.1 - 2e-20 71.1 17.5 0.0039 17.3 0.0 12.6 14 0 0 14 14 11 3 HEAT repeat Importin_rep_5 PF18816.1 EXF77250.1 - 2.4e-20 72.6 4.9 5.8e-20 71.3 0.9 3.5 4 0 0 4 4 3 1 Importin repeat HEAT_2 PF13646.6 EXF77250.1 - 6.7e-19 68.1 10.5 1.5e-06 28.5 0.1 8.3 4 2 2 6 6 6 3 HEAT repeats Vac14_Fab1_bd PF12755.7 EXF77250.1 - 1.2e-13 51.4 0.9 0.0036 17.9 0.0 8.2 5 3 5 10 10 8 2 Vacuolar 14 Fab1-binding region Importin_rep_6 PF18829.1 EXF77250.1 - 5.3e-13 49.1 2.6 1e-11 44.9 0.3 3.4 3 0 0 3 3 3 1 Importin repeat 6 DUF3385 PF11865.8 EXF77250.1 - 2.3e-09 37.4 0.2 0.06 13.2 0.1 6.3 6 1 1 7 7 7 1 Domain of unknown function (DUF3385) DRIM PF07539.12 EXF77250.1 - 1.8e-08 33.2 1.7 0.00025 19.5 0.6 4.1 3 2 1 4 4 4 2 Down-regulated in metastasis RIX1 PF08167.12 EXF77250.1 - 1.2e-07 31.6 0.0 0.00039 20.2 0.0 4.7 3 1 1 4 4 4 2 rRNA processing/ribosome biogenesis CLASP_N PF12348.8 EXF77250.1 - 1.4e-07 31.3 0.9 0.0018 17.9 0.1 5.3 5 1 1 6 6 6 1 CLASP N terminal Cnd1 PF12717.7 EXF77250.1 - 2.2e-07 31.0 0.7 0.14 12.2 0.0 6.0 5 3 0 5 5 5 1 non-SMC mitotic condensation complex subunit 1 MMS19_C PF12460.8 EXF77250.1 - 6.8e-07 28.7 3.5 2.8e-06 26.7 0.3 3.6 3 1 0 4 4 4 1 RNAPII transcription regulator C-terminal DUF3535 PF12054.8 EXF77250.1 - 0.00028 20.3 0.4 0.00098 18.5 0.4 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF3535) Arm PF00514.23 EXF77250.1 - 0.00037 20.4 8.8 1.2 9.3 0.0 5.6 5 0 0 5 5 5 2 Armadillo/beta-catenin-like repeat UNC45-central PF11701.8 EXF77250.1 - 0.00047 20.1 4.0 0.44 10.5 0.6 4.6 3 1 0 3 3 3 1 Myosin-binding striated muscle assembly central DUF4042 PF13251.6 EXF77250.1 - 0.00053 19.7 0.2 8.5 6.0 0.0 4.7 5 0 0 5 5 5 0 Domain of unknown function (DUF4042) Adaptin_N PF01602.20 EXF77250.1 - 0.0015 17.2 2.2 0.038 12.6 0.5 3.2 2 1 1 3 3 3 1 Adaptin N terminal region IFRD PF05004.13 EXF77250.1 - 0.0021 17.2 8.3 0.53 9.3 0.2 4.7 5 1 1 6 6 5 2 Interferon-related developmental regulator (IFRD) RTP1_C1 PF10363.9 EXF77250.1 - 0.0022 18.2 1.0 0.32 11.2 0.5 4.5 4 1 2 6 6 5 1 Required for nuclear transport of RNA pol II C-terminus 1 IBN_N PF03810.19 EXF77250.1 - 0.0047 16.8 1.0 0.046 13.6 0.1 3.4 3 1 1 4 4 3 1 Importin-beta N-terminal domain Cohesin_HEAT PF12765.7 EXF77250.1 - 0.017 15.4 0.7 2 8.8 0.0 3.5 3 0 0 3 3 3 0 HEAT repeat associated with sister chromatid cohesion CAS_CSE1 PF03378.15 EXF77250.1 - 0.017 13.6 0.3 7.4 4.9 0.1 3.3 1 1 2 3 3 3 0 CAS/CSE protein, C-terminus DNA_alkylation PF08713.11 EXF77250.1 - 0.037 13.7 0.1 0.45 10.2 0.0 2.8 2 1 1 3 3 2 0 DNA alkylation repair enzyme TFCD_C PF12612.8 EXF77250.1 - 0.041 13.7 0.0 1.8 8.4 0.0 3.3 2 1 0 3 3 3 0 Tubulin folding cofactor D C terminal Cnd3 PF12719.7 EXF77250.1 - 0.041 13.1 0.0 1.8 7.6 0.0 3.2 2 1 0 2 2 2 0 Nuclear condensing complex subunits, C-term domain Xpo1 PF08389.12 EXF77250.1 - 0.071 13.2 0.0 2 8.5 0.0 3.0 2 0 0 2 2 2 0 Exportin 1-like protein Telomere_reg-2 PF10193.9 EXF77250.1 - 0.11 13.0 4.9 0.32 11.5 1.9 3.3 3 2 2 5 5 4 0 Telomere length regulation protein V-ATPase_H_N PF03224.14 EXF77250.1 - 0.19 11.0 4.4 0.25 10.6 0.4 3.0 2 2 0 3 3 3 0 V-ATPase subunit H YihI PF04220.12 EXF77250.1 - 3.5 7.4 5.4 0.46 10.2 0.6 2.0 2 0 0 2 2 1 0 Der GTPase activator (YihI) PAS_9 PF13426.7 EXF77252.1 - 2e-24 85.8 0.0 2.4e-16 59.9 0.0 3.6 3 0 0 3 3 3 3 PAS domain PAS_3 PF08447.12 EXF77252.1 - 4.6e-20 71.7 0.0 8.8e-12 45.2 0.0 3.7 3 0 0 3 3 3 3 PAS fold PAS PF00989.25 EXF77252.1 - 6.9e-16 58.3 0.0 9.2e-07 28.9 0.0 4.0 3 1 0 3 3 3 3 PAS fold GATA PF00320.27 EXF77252.1 - 2.5e-15 55.8 7.4 5.8e-15 54.6 7.4 1.6 1 0 0 1 1 1 1 GATA zinc finger PAS_4 PF08448.10 EXF77252.1 - 3.8e-09 36.8 0.0 0.0081 16.4 0.0 3.5 3 0 0 3 3 3 2 PAS fold PAS_11 PF14598.6 EXF77252.1 - 6.7e-07 29.4 0.0 0.0055 16.8 0.0 2.8 2 0 0 2 2 2 2 PAS domain PAS_2 PF08446.11 EXF77252.1 - 3.6e-05 24.4 0.0 0.12 13.0 0.0 3.5 3 0 0 3 3 3 1 PAS fold RTA1 PF04479.13 EXF77253.1 - 3.4e-41 141.2 5.2 4.4e-41 140.8 5.2 1.1 1 0 0 1 1 1 1 RTA1 like protein DUF4501 PF14946.6 EXF77253.1 - 0.28 11.2 0.6 1 9.4 0.1 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4501) Inp1 PF12634.7 EXF77254.1 - 2.8e-35 121.3 0.0 7e-35 120.0 0.0 1.7 1 0 0 1 1 1 1 Inheritance of peroxisomes protein 1 EI24 PF07264.11 EXF77255.1 - 4.6e-13 49.8 7.1 4.5e-07 30.3 1.2 2.1 1 1 1 2 2 2 2 Etoposide-induced protein 2.4 (EI24) Lumazine_bd_2 PF12893.7 EXF77255.1 - 0.014 16.0 0.1 0.037 14.7 0.1 1.6 1 0 0 1 1 1 0 Putative lumazine-binding FmdA_AmdA PF03069.15 EXF77256.1 - 4.5e-179 595.1 0.0 5.2e-179 594.9 0.0 1.0 1 0 0 1 1 1 1 Acetamidase/Formamidase family OTU PF02338.19 EXF77257.1 - 6.2e-10 39.7 0.0 9.7e-10 39.0 0.0 1.3 1 0 0 1 1 1 1 OTU-like cysteine protease Bromodomain PF00439.25 EXF77258.1 - 2.2e-39 133.4 2.4 1.5e-19 69.8 0.2 2.6 2 0 0 2 2 2 2 Bromodomain BAH PF01426.18 EXF77258.1 - 3.9e-16 59.0 0.7 1.4e-15 57.2 0.7 2.0 1 0 0 1 1 1 1 BAH domain CDC45 PF02724.14 EXF77258.1 - 0.0021 16.4 9.7 0.0021 16.4 9.7 2.8 3 0 0 3 3 3 1 CDC45-like protein Ribosomal_60s PF00428.19 EXF77258.1 - 0.012 16.2 7.4 0.012 16.2 7.4 4.6 3 1 0 3 3 3 0 60s Acidic ribosomal protein DUF913 PF06025.12 EXF77258.1 - 0.024 13.6 0.3 0.024 13.6 0.3 2.9 3 0 0 3 3 3 0 Domain of Unknown Function (DUF913) Borrelia_REV PF03978.13 EXF77258.1 - 0.089 12.8 0.2 0.17 11.8 0.2 1.4 1 0 0 1 1 1 0 Borrelia burgdorferi REV protein adh_short_C2 PF13561.6 EXF77260.1 - 4.1e-40 137.8 1.6 4.8e-40 137.6 1.6 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF77260.1 - 1.9e-39 135.2 1.5 2.4e-39 134.8 1.5 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EXF77260.1 - 1.4e-07 31.6 0.2 1.8e-07 31.2 0.2 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EXF77260.1 - 0.0024 17.4 1.1 0.026 14.0 1.0 2.2 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF3403 PF11883.8 EXF77262.1 - 0.86 9.8 4.6 22 5.3 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3403) Pyr_redox_2 PF07992.14 EXF77263.1 - 4.7e-22 78.6 0.2 1e-21 77.5 0.2 1.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EXF77263.1 - 4.5e-05 23.6 0.0 0.00024 21.3 0.0 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 EXF77263.1 - 4.5e-05 22.3 0.0 0.0036 16.0 0.0 2.2 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox_3 PF13738.6 EXF77263.1 - 0.00011 21.5 0.1 0.023 13.9 0.0 2.9 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EXF77263.1 - 0.00017 21.3 1.0 0.0012 18.6 0.5 2.3 1 1 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 EXF77263.1 - 0.00026 20.3 0.0 0.00044 19.6 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain FAD_binding_2 PF00890.24 EXF77263.1 - 0.00032 19.9 0.1 0.0036 16.5 0.0 2.2 2 0 0 2 2 2 1 FAD binding domain K_oxygenase PF13434.6 EXF77263.1 - 0.0021 17.3 0.0 0.9 8.6 0.0 2.1 2 0 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) GIDA PF01134.22 EXF77263.1 - 0.0028 16.8 0.0 0.0049 16.0 0.0 1.5 1 0 0 1 1 1 1 Glucose inhibited division protein A NAD_binding_9 PF13454.6 EXF77263.1 - 0.005 16.9 0.3 0.36 10.8 0.0 2.4 2 0 0 2 2 2 1 FAD-NAD(P)-binding Thi4 PF01946.17 EXF77263.1 - 0.0068 15.7 0.0 0.012 14.9 0.0 1.4 1 0 0 1 1 1 1 Thi4 family Lycopene_cycl PF05834.12 EXF77263.1 - 0.018 14.1 0.0 0.052 12.6 0.0 1.8 2 0 0 2 2 2 0 Lycopene cyclase protein FAD_oxidored PF12831.7 EXF77263.1 - 0.035 13.5 0.0 0.059 12.7 0.0 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase Pyr_redox PF00070.27 EXF77263.1 - 0.078 13.5 0.1 23 5.6 0.0 3.0 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Cytochrom_C PF00034.21 EXF77263.1 - 0.12 13.5 0.0 0.27 12.4 0.0 1.6 1 0 0 1 1 1 0 Cytochrome c Methyltransf_23 PF13489.6 EXF77264.1 - 6.7e-14 52.1 0.0 9.9e-14 51.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF77264.1 - 3.7e-12 46.3 0.0 5.8e-12 45.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF77264.1 - 1.9e-11 44.5 0.0 7e-11 42.7 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF77264.1 - 2.5e-11 44.0 0.0 4.9e-11 43.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF77264.1 - 1e-10 42.2 0.0 1.8e-10 41.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EXF77264.1 - 0.00017 21.0 0.0 0.00024 20.5 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family DREV PF05219.12 EXF77264.1 - 0.086 11.9 0.0 0.13 11.3 0.0 1.4 1 1 0 1 1 1 0 DREV methyltransferase Mito_carr PF00153.27 EXF77265.1 - 6.9e-48 160.5 1.8 2.8e-19 68.8 0.1 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Heliorhodopsin PF18761.1 EXF77265.1 - 0.072 12.4 0.6 8.6 5.6 0.0 2.5 2 0 0 2 2 2 0 Heliorhodopsin HET PF06985.11 EXF77267.1 - 1.5e-27 96.8 0.3 3.2e-27 95.7 0.3 1.6 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Rad54_N PF08658.10 EXF77268.1 - 1.2e-58 198.3 3.1 6.7e-58 195.8 3.6 1.9 2 0 0 2 2 2 1 Rad54 N terminal SNF2_N PF00176.23 EXF77268.1 - 5.1e-58 196.5 0.0 9.6e-58 195.6 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EXF77268.1 - 6e-16 58.8 0.0 1.4e-15 57.6 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EXF77268.1 - 3.3e-08 33.7 0.0 6.9e-08 32.7 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 EXF77268.1 - 0.0016 17.7 0.0 0.0069 15.6 0.0 1.9 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 Citrate_ly_lig PF08218.11 EXF77268.1 - 0.066 12.9 0.0 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 Citrate lyase ligase C-terminal domain SWI2_SNF2 PF18766.1 EXF77268.1 - 0.1 12.2 0.1 0.32 10.6 0.0 1.9 2 1 0 2 2 2 0 SWI2/SNF2 ATPase Glyco_transf_24 PF18404.1 EXF77269.1 - 1.7e-148 493.2 3.3 2.7e-148 492.6 3.3 1.3 1 0 0 1 1 1 1 Glucosyltransferase 24 Thioredoxin_14 PF18402.1 EXF77269.1 - 4.9e-70 236.4 0.1 3.5e-69 233.6 0.1 2.3 2 0 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_15 PF18403.1 EXF77269.1 - 4.7e-56 190.1 0.3 8.7e-55 185.9 0.0 2.6 2 0 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_13 PF18401.1 EXF77269.1 - 7.1e-48 162.0 0.8 4.2e-46 156.2 0.3 3.0 3 0 0 3 3 3 1 Thioredoxin-like domain Thioredoxin_12 PF18400.1 EXF77269.1 - 5.5e-47 160.1 0.0 1.4e-46 158.8 0.0 1.8 1 0 0 1 1 1 1 Thioredoxin-like domain UDP-g_GGTase PF06427.11 EXF77269.1 - 1.1e-42 144.6 0.0 2.2e-42 143.6 0.0 1.6 1 0 0 1 1 1 1 UDP-glucose:Glycoprotein Glucosyltransferase Glyco_transf_8 PF01501.20 EXF77269.1 - 2.2e-06 27.4 0.2 4.2e-06 26.5 0.2 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 8 Coatomer_WDAD PF04053.14 EXF77270.1 - 4.6e-146 487.4 0.0 1e-145 486.3 0.0 1.6 1 0 0 1 1 1 1 Coatomer WD associated region COPI_C PF06957.11 EXF77270.1 - 2.1e-99 333.0 0.0 3e-99 332.5 0.0 1.1 1 0 0 1 1 1 1 Coatomer (COPI) alpha subunit C-terminus WD40 PF00400.32 EXF77270.1 - 4.3e-35 119.1 16.0 2.5e-07 31.3 0.2 7.7 8 0 0 8 8 8 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EXF77270.1 - 9e-09 35.5 0.6 0.0016 18.7 0.0 5.5 3 2 5 8 8 8 3 Anaphase-promoting complex subunit 4 WD40 domain Clathrin PF00637.20 EXF77270.1 - 0.021 14.7 0.4 0.19 11.6 0.0 2.3 2 0 0 2 2 2 0 Region in Clathrin and VPS Nup160 PF11715.8 EXF77270.1 - 0.021 13.5 7.1 2.4 6.7 0.1 4.0 2 1 1 4 4 4 0 Nucleoporin Nup120/160 IPPT PF01715.17 EXF77270.1 - 0.074 12.8 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 IPP transferase CSN8_PSD8_EIF3K PF10075.9 EXF77271.1 - 2.3e-16 60.1 0.0 4.7e-08 33.1 0.0 2.2 2 0 0 2 2 2 2 CSN8/PSMD8/EIF3K family GSP_synth PF03738.14 EXF77273.1 - 9.7e-115 383.7 0.0 1.2e-114 383.5 0.0 1.1 1 0 0 1 1 1 1 Glutathionylspermidine synthase preATP-grasp ScsC_N PF18312.1 EXF77273.1 - 0.091 12.6 0.1 0.37 10.6 0.0 2.0 2 0 0 2 2 2 0 Copper resistance protein ScsC N-terminal domain DUF4124 PF13511.6 EXF77274.1 - 0.0093 16.3 0.9 0.016 15.5 0.9 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4124) Sel1 PF08238.12 EXF77275.1 - 2.5e-15 56.5 30.7 1.4e-06 28.8 0.2 8.0 8 0 0 8 8 8 6 Sel1 repeat TPR_1 PF00515.28 EXF77275.1 - 0.00052 19.7 0.2 0.0025 17.6 0.2 2.3 1 0 0 1 1 1 1 Tetratricopeptide repeat Epimerase PF01370.21 EXF77276.1 - 2.5e-14 53.4 0.0 5e-14 52.4 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EXF77276.1 - 1e-11 45.1 0.0 1.7e-11 44.4 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 EXF77276.1 - 3.6e-10 39.8 0.0 1e-09 38.2 0.0 1.6 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 EXF77276.1 - 5.1e-08 32.2 0.0 7.2e-08 31.8 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 EXF77276.1 - 8.4e-07 28.4 0.0 0.00029 20.1 0.0 2.1 2 0 0 2 2 2 2 Male sterility protein NmrA PF05368.13 EXF77276.1 - 7.7e-06 25.6 0.1 2e-05 24.3 0.1 1.7 1 1 0 1 1 1 1 NmrA-like family adh_short PF00106.25 EXF77276.1 - 0.015 14.8 0.5 0.027 13.9 0.0 1.7 2 1 0 2 2 2 0 short chain dehydrogenase Polysacc_synt_2 PF02719.15 EXF77276.1 - 0.022 13.9 0.0 0.03 13.5 0.0 1.1 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein SOG2 PF10428.9 EXF77277.1 - 0.013 14.7 18.9 0.018 14.3 18.9 1.3 1 0 0 1 1 1 0 RAM signalling pathway protein Pep_deformylase PF01327.21 EXF77277.1 - 0.049 13.2 0.4 0.13 11.9 0.4 1.7 1 0 0 1 1 1 0 Polypeptide deformylase Prominin PF05478.11 EXF77277.1 - 0.058 11.4 6.2 0.085 10.8 6.2 1.2 1 0 0 1 1 1 0 Prominin ParB PF08775.10 EXF77277.1 - 1.3 9.5 12.0 0.35 11.3 3.8 3.2 2 1 1 3 3 3 0 ParB family DUF1664 PF07889.12 EXF77277.1 - 1.5 8.8 9.9 7.3 6.6 0.8 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DUF724 PF05266.14 EXF77277.1 - 4.2 7.2 9.7 1.4 8.7 6.7 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF724) BEX PF04538.12 EXF77277.1 - 4.2 8.0 10.3 0.21 12.2 1.7 2.4 2 0 0 2 2 2 0 Brain expressed X-linked like family EF-G-binding_N PF07299.11 EXF77277.1 - 6.1 7.4 8.8 13 6.4 1.0 3.5 2 1 1 3 3 3 0 Elongation factor G-binding protein, N-terminal Osmo_MPGsynth PF09488.10 EXF77278.1 - 1.7e-153 511.0 0.0 1.9e-153 510.7 0.0 1.0 1 0 0 1 1 1 1 Mannosyl-3-phosphoglycerate synthase (osmo_MPGsynth) CW_binding_2 PF04122.12 EXF77278.1 - 0.099 13.3 0.1 0.24 12.1 0.1 1.7 1 0 0 1 1 1 0 Putative cell wall binding repeat 2 MFS_1 PF07690.16 EXF77279.1 - 1.8e-24 86.4 40.6 2.3e-24 86.0 40.6 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily AAA_12 PF13087.6 EXF77281.1 - 3.9e-41 140.9 0.0 6e-41 140.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 EXF77281.1 - 1.3e-22 80.9 0.0 3.6e-22 79.4 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EXF77281.1 - 1.8e-09 38.1 0.0 8.9e-09 35.8 0.0 2.2 1 1 0 1 1 1 1 AAA domain zf-CCCH PF00642.24 EXF77281.1 - 1e-08 34.8 3.7 2.5e-08 33.6 3.7 1.7 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) AAA_30 PF13604.6 EXF77281.1 - 5.1e-06 26.3 0.0 0.0016 18.2 0.0 2.7 2 0 0 2 2 2 1 AAA domain zf_CCCH_4 PF18345.1 EXF77281.1 - 1.2e-05 25.2 6.1 2.9e-05 23.9 6.1 1.7 1 0 0 1 1 1 1 Zinc finger domain DUF2075 PF09848.9 EXF77281.1 - 4.4e-05 22.9 0.1 0.29 10.3 0.0 2.3 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) zf-CCCH_4 PF18044.1 EXF77281.1 - 0.00011 21.9 4.1 0.00031 20.5 4.1 1.7 1 0 0 1 1 1 1 CCCH-type zinc finger Viral_helicase1 PF01443.18 EXF77281.1 - 0.0011 18.8 1.2 0.015 15.0 0.0 3.0 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase Torus PF16131.5 EXF77281.1 - 0.038 14.7 0.3 0.085 13.6 0.3 1.5 1 0 0 1 1 1 0 Torus domain CHS5_N PF16892.5 EXF77281.1 - 0.039 13.9 0.2 0.11 12.4 0.2 1.7 1 0 0 1 1 1 0 Chitin biosynthesis protein CHS5 N-terminus UvrD_C_2 PF13538.6 EXF77281.1 - 0.05 13.4 0.0 0.11 12.3 0.0 1.7 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain zf-CCCH_2 PF14608.6 EXF77281.1 - 0.067 13.7 1.5 0.21 12.1 1.5 1.9 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger ResIII PF04851.15 EXF77281.1 - 0.069 13.1 0.0 0.45 10.5 0.0 2.1 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit FtsK_SpoIIIE PF01580.18 EXF77281.1 - 0.093 12.1 0.0 4 6.7 0.0 2.6 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA PF00004.29 EXF77281.1 - 0.17 12.3 0.0 0.74 10.2 0.0 2.2 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EXF77281.1 - 0.2 12.0 1.0 1.4 9.2 0.0 2.8 3 0 0 3 3 3 0 AAA domain Zn-ribbon_8 PF09723.10 EXF77281.1 - 9.6 6.4 10.2 1 9.5 0.7 3.1 3 0 0 3 3 2 0 Zinc ribbon domain EI24 PF07264.11 EXF77283.1 - 3.4e-09 37.2 21.0 7.3e-09 36.1 21.0 1.5 1 1 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) Fungal_trans PF04082.18 EXF77284.1 - 2.1e-07 30.3 0.0 4.1e-07 29.3 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF77284.1 - 1.3e-06 28.4 9.1 1.3e-06 28.4 9.1 1.6 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SGL PF08450.12 EXF77285.1 - 3.3e-24 85.8 0.8 5.9e-24 85.0 0.8 1.5 1 1 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Str_synth PF03088.16 EXF77285.1 - 6.8e-06 26.1 0.0 3e-05 24.0 0.0 2.0 1 1 0 1 1 1 1 Strictosidine synthase Arylesterase PF01731.20 EXF77285.1 - 0.0027 17.9 0.1 0.015 15.5 0.0 2.3 2 0 0 2 2 2 1 Arylesterase NHL PF01436.21 EXF77285.1 - 0.14 12.2 0.3 27 5.1 0.0 2.8 2 0 0 2 2 2 0 NHL repeat SDH_alpha PF03313.15 EXF77286.1 - 1.3e-99 333.1 0.1 1.8e-99 332.6 0.1 1.2 1 0 0 1 1 1 1 Serine dehydratase alpha chain SDH_beta PF03315.15 EXF77286.1 - 2.5e-54 183.8 0.0 6.5e-54 182.5 0.0 1.7 1 0 0 1 1 1 1 Serine dehydratase beta chain Cyt-b5 PF00173.28 EXF77288.1 - 1.4e-14 54.0 0.0 3.3e-14 52.8 0.0 1.7 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain IDO PF01231.18 EXF77288.1 - 5.8e-14 51.7 0.0 2.9e-11 42.8 0.0 2.9 1 1 0 1 1 1 1 Indoleamine 2,3-dioxygenase NAD_binding_1 PF00175.21 EXF77288.1 - 0.00085 19.9 0.0 0.0031 18.2 0.0 2.0 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain DUF3703 PF12487.8 EXF77288.1 - 0.18 11.7 0.6 0.39 10.6 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3703) p450 PF00067.22 EXF77289.1 - 1.2e-66 225.4 0.0 1.6e-66 225.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Trp_DMAT PF11991.8 EXF77290.1 - 6.4e-71 239.7 0.0 8e-71 239.4 0.0 1.0 1 0 0 1 1 1 1 Tryptophan dimethylallyltransferase Methyltransf_2 PF00891.18 EXF77291.1 - 1.3e-13 50.7 0.0 3.9e-13 49.2 0.0 1.8 1 1 0 1 1 1 1 O-methyltransferase domain Methyltransf_23 PF13489.6 EXF77291.1 - 0.027 14.3 0.0 0.053 13.4 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.6 EXF77291.1 - 0.05 14.3 0.0 0.21 12.3 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase domain Dimerisation2 PF16864.5 EXF77291.1 - 0.13 12.2 0.0 0.23 11.4 0.0 1.4 1 0 0 1 1 1 0 Dimerisation domain ABC2_membrane PF01061.24 EXF77292.1 - 2e-69 233.2 45.6 4.7e-37 127.5 17.3 2.7 3 0 0 3 3 3 2 ABC-2 type transporter ABC_tran PF00005.27 EXF77292.1 - 1.7e-31 109.6 0.0 1.3e-15 58.1 0.0 3.0 3 0 0 3 3 3 2 ABC transporter PDR_CDR PF06422.12 EXF77292.1 - 1.9e-31 107.8 0.2 5e-27 93.6 0.0 3.1 2 0 0 2 2 2 2 CDR ABC transporter ABC_trans_N PF14510.6 EXF77292.1 - 1.1e-14 54.8 0.1 3e-14 53.4 0.1 1.8 1 0 0 1 1 1 1 ABC-transporter N-terminal ABC2_membrane_3 PF12698.7 EXF77292.1 - 3.4e-09 36.3 29.1 4.6e-05 22.7 12.9 2.7 2 1 0 2 2 2 2 ABC-2 family transporter protein RsgA_GTPase PF03193.16 EXF77292.1 - 5.8e-08 32.8 0.1 4.3e-05 23.5 0.0 2.6 2 0 0 2 2 2 1 RsgA GTPase AAA_16 PF13191.6 EXF77292.1 - 1.3e-07 32.2 0.3 0.00046 20.6 0.2 2.6 2 0 0 2 2 2 2 AAA ATPase domain AAA_33 PF13671.6 EXF77292.1 - 5.2e-07 29.9 0.0 0.0051 17.0 0.0 3.8 4 0 0 4 4 3 1 AAA domain AAA_18 PF13238.6 EXF77292.1 - 8.4e-06 26.4 0.0 0.00034 21.2 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 EXF77292.1 - 2.7e-05 23.8 1.1 0.0023 17.7 0.2 2.9 3 0 0 3 3 2 1 P-loop containing region of AAA domain SMC_N PF02463.19 EXF77292.1 - 0.00028 20.4 0.0 0.13 11.7 0.0 2.9 3 1 1 4 4 4 1 RecF/RecN/SMC N terminal domain AAA_25 PF13481.6 EXF77292.1 - 0.00033 20.3 0.1 0.0048 16.5 0.1 2.3 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EXF77292.1 - 0.00084 19.6 0.4 0.14 12.4 0.0 3.0 3 0 0 3 3 2 1 AAA domain AAA_21 PF13304.6 EXF77292.1 - 0.0013 18.6 0.1 0.38 10.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_28 PF13521.6 EXF77292.1 - 0.0021 18.3 0.2 0.36 11.1 0.1 2.9 3 0 0 3 3 3 1 AAA domain cobW PF02492.19 EXF77292.1 - 0.0025 17.4 0.2 0.11 12.0 0.1 2.3 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.12 EXF77292.1 - 0.004 17.1 1.3 0.36 10.7 0.1 3.1 3 0 0 3 3 2 1 NACHT domain AAA_17 PF13207.6 EXF77292.1 - 0.004 17.6 0.1 0.15 12.5 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 EXF77292.1 - 0.034 14.6 0.1 3.4 8.1 0.0 2.6 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 EXF77292.1 - 0.038 13.7 0.2 1.8 8.2 0.2 2.5 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 EXF77292.1 - 0.049 14.1 0.0 0.15 12.5 0.0 1.8 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 EXF77292.1 - 0.14 12.3 0.0 7.5 6.7 0.0 2.6 2 0 0 2 2 2 0 50S ribosome-binding GTPase RNA_helicase PF00910.22 EXF77292.1 - 0.16 12.4 0.0 31 5.0 0.0 2.8 2 0 0 2 2 2 0 RNA helicase TsaE PF02367.17 EXF77292.1 - 0.16 12.0 0.4 1.1 9.2 0.2 2.4 3 0 0 3 3 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_24 PF13479.6 EXF77292.1 - 0.16 11.6 0.1 13 5.4 0.0 2.4 2 0 0 2 2 2 0 AAA domain Viral_helicase1 PF01443.18 EXF77292.1 - 0.21 11.3 0.1 1.9 8.2 0.0 2.5 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase FAD_binding_3 PF01494.19 EXF77293.1 - 5e-57 193.7 0.0 1.3e-29 103.6 0.0 2.1 2 0 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 EXF77293.1 - 0.00015 22.0 0.0 0.00034 20.8 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EXF77293.1 - 0.00061 19.5 0.0 0.0019 17.9 0.0 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.17 EXF77293.1 - 0.0039 16.5 0.0 0.0062 15.8 0.0 1.3 1 0 0 1 1 1 1 Thi4 family Pyr_redox_3 PF13738.6 EXF77293.1 - 0.014 14.6 0.0 0.022 14.0 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EXF77293.1 - 0.037 13.1 0.0 0.48 9.4 0.0 2.1 2 0 0 2 2 2 0 FAD binding domain HI0933_like PF03486.14 EXF77293.1 - 0.071 11.8 0.0 0.11 11.2 0.0 1.2 1 0 0 1 1 1 0 HI0933-like protein MFS_1 PF07690.16 EXF77295.1 - 4.4e-20 71.9 24.8 4.4e-20 71.9 24.8 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF77295.1 - 1e-14 54.3 25.1 3.6e-14 52.5 25.1 1.7 1 1 0 1 1 1 1 Sugar (and other) transporter DUF2583 PF10762.9 EXF77295.1 - 0.081 13.3 0.7 0.29 11.6 0.7 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2583) PfkB PF00294.24 EXF77296.1 - 4.6e-11 42.6 0.0 1.4e-08 34.4 0.0 2.8 2 1 0 2 2 2 2 pfkB family carbohydrate kinase DUF3546 PF12066.8 EXF77298.1 - 4.4e-34 117.0 2.8 4.4e-34 117.0 2.8 3.1 4 0 0 4 4 4 1 Domain of unknown function (DUF3546) DUF4187 PF13821.6 EXF77298.1 - 2e-12 46.7 0.1 4.9e-12 45.4 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4187) ARS2 PF04959.13 EXF77298.1 - 5.9e-07 30.0 4.2 2.1e-06 28.3 4.2 1.9 1 0 0 1 1 1 1 Arsenite-resistance protein 2 zf-C2H2_2 PF12756.7 EXF77298.1 - 0.3 11.4 3.6 1.1 9.7 0.9 2.6 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) TspO_MBR PF03073.15 EXF77299.1 - 7.7e-44 149.0 7.6 9.3e-44 148.8 7.6 1.1 1 0 0 1 1 1 1 TspO/MBR family Mito_carr PF00153.27 EXF77300.1 - 5.1e-59 196.2 0.1 1e-19 70.2 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Antimicrobial_6 PF08036.11 EXF77300.1 - 0.44 10.6 1.8 31 4.7 0.1 2.5 2 0 0 2 2 2 0 Diapausin family of antimicrobial peptide DEAD PF00270.29 EXF77301.1 - 7.4e-47 159.4 0.0 4.7e-46 156.8 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EXF77301.1 - 1.2e-29 102.9 0.0 4e-28 98.0 0.1 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EXF77301.1 - 0.00079 19.5 0.0 0.0028 17.7 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit PRAI PF00697.22 EXF77301.1 - 0.02 14.7 0.1 0.042 13.6 0.1 1.5 1 0 0 1 1 1 0 N-(5'phosphoribosyl)anthranilate (PRA) isomerase CMS1 PF14617.6 EXF77301.1 - 3.3 7.0 9.5 0.88 8.9 0.0 2.7 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit Mitoc_mL59 PF18126.1 EXF77302.1 - 4.1e-42 143.5 3.0 4.8e-42 143.3 3.0 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein mL59 zf-CSL PF05207.13 EXF77303.1 - 1.5e-18 66.2 0.8 2.3e-18 65.6 0.8 1.3 1 0 0 1 1 1 1 CSL zinc finger DnaJ PF00226.31 EXF77303.1 - 1.2e-13 50.9 0.9 8.6e-12 45.0 0.9 2.3 1 1 0 1 1 1 1 DnaJ domain 14-3-3 PF00244.20 EXF77304.1 - 1.4e-106 354.9 2.8 1.7e-106 354.7 2.8 1.0 1 0 0 1 1 1 1 14-3-3 protein IATP PF04568.12 EXF77305.1 - 8.6e-30 103.1 1.9 9.5e-30 102.9 1.9 1.0 1 0 0 1 1 1 1 Mitochondrial ATPase inhibitor, IATP DUF489 PF04356.12 EXF77305.1 - 0.037 14.1 0.5 0.047 13.7 0.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF489) DUF2205 PF10224.9 EXF77305.1 - 0.091 12.8 3.4 0.13 12.3 3.4 1.2 1 0 0 1 1 1 0 Short coiled-coil protein NPV_P10 PF05531.12 EXF77305.1 - 0.13 12.8 1.0 0.18 12.3 1.0 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein XhlA PF10779.9 EXF77305.1 - 0.27 11.5 2.3 0.41 10.9 2.3 1.3 1 0 0 1 1 1 0 Haemolysin XhlA DUF1003 PF06210.11 EXF77305.1 - 0.42 10.7 1.6 0.68 10.1 1.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1003) Nsp1_C PF05064.13 EXF77306.1 - 8.3e-39 132.0 1.4 8.3e-39 132.0 1.4 1.5 2 0 0 2 2 2 1 Nsp1-like C-terminal region Nucleoporin_FG PF13634.6 EXF77306.1 - 2.4e-19 69.9 205.3 1.6e-07 32.1 32.9 8.5 2 1 6 8 8 8 5 Nucleoporin FG repeat region Myosin_tail_1 PF01576.19 EXF77306.1 - 0.037 11.9 4.5 0.05 11.4 4.5 1.1 1 0 0 1 1 1 0 Myosin tail Nup88 PF10168.9 EXF77306.1 - 0.053 11.3 1.6 0.067 11.0 1.6 1.1 1 0 0 1 1 1 0 Nuclear pore component DUF4200 PF13863.6 EXF77306.1 - 0.087 13.2 2.3 3.3 8.1 0.7 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) NPV_P10 PF05531.12 EXF77306.1 - 0.5 10.9 1.3 3.6 8.1 0.1 2.6 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein PI_PP_I PF18363.1 EXF77306.1 - 0.55 10.4 3.3 0.3 11.3 0.7 1.8 2 1 0 2 2 2 0 Phosphoinositide phosphatase insertion domain Laminin_II PF06009.12 EXF77306.1 - 1.1 9.3 3.2 23 5.0 0.2 2.6 1 1 2 3 3 3 0 Laminin Domain II APG6_N PF17675.1 EXF77306.1 - 1.7 9.2 6.6 2.2 8.8 6.2 1.4 1 1 0 1 1 1 0 Apg6 coiled-coil region OmpH PF03938.14 EXF77306.1 - 3.4 8.0 9.6 1.6 9.0 6.6 1.9 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) DUF5102 PF17104.5 EXF77307.1 - 4.4e-115 384.7 1.5 4.4e-115 384.7 1.5 1.8 1 1 1 2 2 2 1 Domain of unknown function (DUF5102) Ribosomal_60s PF00428.19 EXF77307.1 - 0.83 10.3 9.1 0.09 13.4 2.9 2.6 3 0 0 3 3 3 0 60s Acidic ribosomal protein eIF2_C PF09173.11 EXF77308.1 - 2.6e-34 117.3 0.5 6.2e-34 116.1 0.5 1.7 1 0 0 1 1 1 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU PF00009.27 EXF77308.1 - 1.2e-22 80.4 1.1 8.5e-22 77.6 1.1 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 EXF77308.1 - 7.8e-11 42.2 0.1 1.7e-10 41.2 0.1 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EXF77308.1 - 0.003 17.6 0.0 0.007 16.4 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase MMR_HSR1_Xtn PF16897.5 EXF77308.1 - 0.0049 16.9 0.8 0.018 15.0 0.1 2.1 2 0 0 2 2 2 1 C-terminal region of MMR_HSR1 domain RsgA_GTPase PF03193.16 EXF77308.1 - 0.023 14.6 0.3 0.23 11.4 0.1 2.2 2 0 0 2 2 2 0 RsgA GTPase Dynamin_N PF00350.23 EXF77308.1 - 0.09 12.8 0.0 0.49 10.4 0.0 2.3 3 0 0 3 3 3 0 Dynamin family Fungal_trans_2 PF11951.8 EXF77310.1 - 3.6e-57 193.9 0.0 5.9e-57 193.2 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Pro_isomerase PF00160.21 EXF77310.1 - 1.5e-50 171.5 1.3 1.8e-50 171.3 0.1 1.7 2 0 0 2 2 2 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD WD40 PF00400.32 EXF77310.1 - 6.1e-11 42.7 0.0 8.5e-05 23.3 0.0 4.9 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EXF77310.1 - 0.0012 19.1 0.0 0.15 12.4 0.0 3.1 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EXF77310.1 - 0.06 12.3 0.2 0.46 9.4 0.1 2.0 1 1 1 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Far-17a_AIG1 PF04750.14 EXF77311.1 - 8.2e-48 162.4 10.5 9.4e-48 162.2 10.5 1.0 1 0 0 1 1 1 1 FAR-17a/AIG1-like protein DUF3185 PF11381.8 EXF77311.1 - 0.031 14.3 1.9 0.031 14.3 1.9 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3185) DAHP_synth_1 PF00793.20 EXF77312.1 - 5.5e-100 333.8 0.0 7.1e-100 333.4 0.0 1.1 1 0 0 1 1 1 1 DAHP synthetase I family Cytochrom_C1 PF02167.15 EXF77313.1 - 7.6e-92 307.0 0.0 9.4e-92 306.7 0.0 1.1 1 0 0 1 1 1 1 Cytochrome C1 family Cytochrome_CBB3 PF13442.6 EXF77313.1 - 0.0078 16.5 0.0 0.017 15.4 0.0 1.7 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C PF00034.21 EXF77313.1 - 0.18 13.0 0.3 0.68 11.1 0.1 2.1 2 1 0 2 2 2 0 Cytochrome c AAA PF00004.29 EXF77315.1 - 1.2e-40 138.9 0.0 2.2e-40 138.2 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EXF77315.1 - 2.1e-07 30.6 0.0 5.3e-07 29.3 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 EXF77315.1 - 6.3e-05 23.0 0.1 0.00043 20.3 0.0 2.5 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EXF77315.1 - 0.00011 22.4 0.0 0.0069 16.7 0.0 2.5 1 1 1 2 2 2 1 AAA domain AAA_2 PF07724.14 EXF77315.1 - 0.0003 20.9 0.0 0.00083 19.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 EXF77315.1 - 0.00051 20.5 0.1 0.01 16.2 0.0 2.3 1 1 0 2 2 2 1 AAA ATPase domain DUF815 PF05673.13 EXF77315.1 - 0.0018 17.5 0.0 0.0033 16.6 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) RuvB_N PF05496.12 EXF77315.1 - 0.008 15.9 0.0 0.016 15.0 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_28 PF13521.6 EXF77315.1 - 0.025 14.8 0.1 0.063 13.5 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 EXF77315.1 - 0.031 13.8 0.0 0.097 12.2 0.0 1.8 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_33 PF13671.6 EXF77315.1 - 0.051 13.7 0.0 0.094 12.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EXF77315.1 - 0.056 13.8 0.0 0.16 12.4 0.0 1.8 1 0 0 1 1 1 0 RNA helicase AAA_30 PF13604.6 EXF77315.1 - 0.069 12.9 0.1 0.59 9.8 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_3 PF07726.11 EXF77315.1 - 0.08 12.8 0.0 0.16 11.9 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 EXF77315.1 - 0.093 12.4 0.1 0.28 10.9 0.0 1.9 2 1 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 EXF77315.1 - 0.1 12.5 0.6 11 5.9 0.0 2.9 2 1 1 3 3 3 0 ATPase domain predominantly from Archaea Mg_chelatase PF01078.21 EXF77315.1 - 0.16 11.3 0.0 0.36 10.2 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Cpn60_TCP1 PF00118.24 EXF77316.1 - 8e-147 489.8 16.1 9e-147 489.6 16.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Phage_tail_X PF05489.12 EXF77316.1 - 0.12 12.1 0.0 0.27 10.9 0.0 1.6 1 0 0 1 1 1 0 Phage Tail Protein X HECT PF00632.25 EXF77316.1 - 0.18 11.2 0.0 0.28 10.6 0.0 1.2 1 0 0 1 1 1 0 HECT-domain (ubiquitin-transferase) ketoacyl-synt PF00109.26 EXF77318.1 - 2.7e-72 243.4 0.0 7.3e-72 242.0 0.0 1.8 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain AMP-binding PF00501.28 EXF77318.1 - 7.1e-72 242.3 0.0 1.1e-71 241.7 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme KR PF08659.10 EXF77318.1 - 1.7e-51 174.7 3.5 1.3e-50 171.8 2.1 2.7 2 0 0 2 2 2 1 KR domain Condensation PF00668.20 EXF77318.1 - 2.6e-51 174.8 0.0 3.8e-51 174.2 0.0 1.2 1 0 0 1 1 1 1 Condensation domain PS-DH PF14765.6 EXF77318.1 - 1e-44 153.0 0.9 3.8e-44 151.1 0.9 2.1 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 EXF77318.1 - 1.4e-44 152.9 1.0 3.3e-44 151.7 1.0 1.6 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EXF77318.1 - 1.3e-27 96.1 0.0 3.5e-27 94.8 0.0 1.8 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Methyltransf_12 PF08242.12 EXF77318.1 - 1.2e-20 74.1 0.1 4.6e-19 69.0 0.0 3.0 3 0 0 3 3 2 1 Methyltransferase domain PP-binding PF00550.25 EXF77318.1 - 4.1e-17 62.3 0.0 1.4e-09 38.2 0.0 3.1 2 0 0 2 2 2 2 Phosphopantetheine attachment site NAD_binding_4 PF07993.12 EXF77318.1 - 1.5e-13 50.5 0.0 6.2e-13 48.5 0.0 2.0 2 0 0 2 2 2 1 Male sterility protein KAsynt_C_assoc PF16197.5 EXF77318.1 - 2.8e-13 50.3 0.0 8.4e-13 48.8 0.0 1.9 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Methyltransf_25 PF13649.6 EXF77318.1 - 1.5e-11 44.9 0.1 3.9e-10 40.3 0.0 3.3 3 0 0 3 3 3 1 Methyltransferase domain adh_short PF00106.25 EXF77318.1 - 2.8e-10 40.0 4.4 1.7e-09 37.4 1.5 3.3 4 0 0 4 4 4 1 short chain dehydrogenase Methyltransf_11 PF08241.12 EXF77318.1 - 4.4e-09 36.9 0.1 3e-08 34.2 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EXF77318.1 - 1.6e-08 34.6 0.0 1.3e-07 31.6 0.0 2.5 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF77318.1 - 1.4e-06 28.2 0.0 4.9e-06 26.4 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Epimerase PF01370.21 EXF77318.1 - 2.8e-06 27.0 0.0 0.023 14.2 0.0 2.5 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family Thiolase_N PF00108.23 EXF77318.1 - 5.5e-06 25.9 0.1 1.4e-05 24.6 0.1 1.6 1 0 0 1 1 1 1 Thiolase, N-terminal domain adh_short_C2 PF13561.6 EXF77318.1 - 8.2e-05 22.3 1.3 0.00027 20.5 1.3 1.9 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Methyltransf_16 PF10294.9 EXF77318.1 - 0.025 14.3 0.0 0.059 13.1 0.0 1.6 1 0 0 1 1 1 0 Lysine methyltransferase AMP-binding_C PF13193.6 EXF77318.1 - 0.09 13.8 1.3 20 6.2 0.0 4.0 3 0 0 3 3 3 0 AMP-binding enzyme C-terminal domain Polysacc_synt_2 PF02719.15 EXF77318.1 - 0.12 11.5 1.3 0.38 9.9 0.1 2.3 3 0 0 3 3 3 0 Polysaccharide biosynthesis protein Ubie_methyltran PF01209.18 EXF77318.1 - 0.15 11.4 0.0 0.35 10.2 0.0 1.6 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Seryl_tRNA_N PF02403.22 EXF77318.1 - 0.56 10.5 2.8 4.4 7.6 0.9 2.4 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain p450 PF00067.22 EXF77319.1 - 1.8e-59 201.8 0.0 2.3e-59 201.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 ADH_zinc_N PF00107.26 EXF77320.1 - 1.3e-07 31.6 0.0 2.4e-07 30.8 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EXF77320.1 - 3e-06 27.1 0.1 8.6e-05 22.4 0.0 2.6 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain Methyltransf_24 PF13578.6 EXF77321.1 - 1.8e-05 25.7 0.0 3.3e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain CmcI PF04989.12 EXF77321.1 - 0.00099 18.9 0.0 0.0015 18.2 0.0 1.2 1 0 0 1 1 1 1 Cephalosporin hydroxylase Adeno_knob PF00541.17 EXF77321.1 - 0.035 13.9 0.0 0.05 13.3 0.0 1.3 1 0 0 1 1 1 0 Adenoviral fibre protein (knob domain) p450 PF00067.22 EXF77322.1 - 1.5e-41 142.6 0.0 3e-41 141.7 0.0 1.3 1 1 0 1 1 1 1 Cytochrome P450 YARHG PF13308.6 EXF77323.1 - 0.087 12.7 0.0 0.2 11.6 0.0 1.6 1 0 0 1 1 1 0 YARHG domain DUF3116 PF11313.8 EXF77323.1 - 0.11 12.3 0.1 0.2 11.5 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3116) BUD22 PF09073.10 EXF77323.1 - 1.1 8.5 13.6 1.4 8.1 13.6 1.1 1 0 0 1 1 1 0 BUD22 NOA36 PF06524.12 EXF77323.1 - 1.6 8.0 19.9 0.22 10.8 3.5 2.1 2 0 0 2 2 2 0 NOA36 protein RXT2_N PF08595.11 EXF77323.1 - 8 6.5 10.8 1.6 8.7 1.1 2.2 2 0 0 2 2 2 0 RXT2-like, N-terminal Pil1 PF13805.6 EXF77324.1 - 9.1e-112 372.9 8.4 1.1e-111 372.6 8.4 1.1 1 0 0 1 1 1 1 Eisosome component PIL1 SpoVT_C PF15714.5 EXF77324.1 - 0.63 10.1 5.1 1.7 8.7 0.1 2.9 3 0 0 3 3 3 0 Stage V sporulation protein T C-terminal, transcription factor Alpha_GJ PF03229.13 EXF77325.1 - 0.0017 18.9 2.5 0.0017 18.9 2.5 2.2 2 0 0 2 2 2 1 Alphavirus glycoprotein J Tnp_DNA_bind PF14706.6 EXF77325.1 - 0.0029 17.4 0.0 3.1 7.7 0.1 3.3 3 0 0 3 3 3 2 Transposase DNA-binding Sod_Fe_C PF02777.18 EXF77326.1 - 2.1e-14 53.5 0.0 1.8e-06 28.0 0.0 2.4 2 0 0 2 2 2 2 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 EXF77326.1 - 0.0015 19.0 0.0 0.0023 18.4 0.0 1.3 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain MFS_1 PF07690.16 EXF77327.1 - 9.6e-29 100.4 20.8 9.6e-29 100.4 20.8 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF77327.1 - 1.7e-08 33.8 2.8 1.7e-08 33.8 2.8 2.5 2 0 0 2 2 2 1 Sugar (and other) transporter DUF2784 PF10861.8 EXF77327.1 - 2.3 8.3 7.5 0.25 11.4 1.2 2.6 2 0 0 2 2 2 0 Protein of Unknown function (DUF2784) Fungal_trans_2 PF11951.8 EXF77329.1 - 4.5e-27 94.9 9.8 6.4e-27 94.3 9.8 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain DUF1147 PF06615.11 EXF77329.1 - 0.091 12.8 0.0 0.21 11.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1147) Aminotran_4 PF01063.19 EXF77330.1 - 5.1e-41 141.0 0.0 6.3e-41 140.7 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV DAO PF01266.24 EXF77331.1 - 2.2e-24 86.7 0.1 2.7e-24 86.4 0.1 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Aldo_ket_red PF00248.21 EXF77332.1 - 1.3e-65 221.5 0.0 1.6e-65 221.2 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Sugar_tr PF00083.24 EXF77333.1 - 3.5e-71 240.4 19.2 4e-71 240.2 19.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF77333.1 - 7.4e-13 48.1 42.6 3e-09 36.3 16.6 2.1 1 1 0 2 2 2 2 Major Facilitator Superfamily DUF4233 PF14017.6 EXF77333.1 - 0.45 10.9 5.5 0.25 11.7 0.4 3.0 3 1 0 3 3 3 0 Protein of unknown function (DUF4233) DUF3245 PF11595.8 EXF77334.1 - 0.21 12.1 2.7 9.1 6.7 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3245) Mito_carr PF00153.27 EXF77335.1 - 5e-67 221.9 1.0 1e-21 76.6 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 EXF77335.1 - 1.9 7.6 6.2 2.7 7.1 0.2 3.2 4 0 0 4 4 4 0 Gammaproteobacterial serine protease Shadoo PF14999.6 EXF77335.1 - 2.7 8.1 6.0 16 5.6 0.8 2.9 3 0 0 3 3 3 0 Shadow of prion protein, neuroprotective Pkinase PF00069.25 EXF77336.1 - 8.2e-50 169.6 0.0 1.2e-49 169.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF77336.1 - 2.5e-27 95.8 0.0 3.3e-27 95.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EXF77336.1 - 0.00045 19.6 0.0 0.00092 18.6 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EXF77336.1 - 0.021 14.2 0.0 0.038 13.4 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EXF77336.1 - 0.085 12.8 0.1 0.72 9.7 0.0 2.4 2 1 1 3 3 3 0 Phosphotransferase enzyme family RIO1 PF01163.22 EXF77336.1 - 0.11 12.0 0.0 0.26 10.9 0.0 1.5 1 0 0 1 1 1 0 RIO1 family F-box PF00646.33 EXF77337.1 - 0.0072 16.2 0.1 0.019 14.9 0.1 1.7 1 0 0 1 1 1 1 F-box domain Pkinase PF00069.25 EXF77338.1 - 1.4e-56 191.8 0.0 3.3e-51 174.2 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EXF77338.1 - 1.1e-32 113.4 0.0 2.3e-31 109.0 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 EXF77338.1 - 8.4e-05 22.0 0.0 0.00035 20.0 0.0 1.8 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 EXF77338.1 - 0.00038 20.4 0.0 0.00069 19.6 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family zf-MYND PF01753.18 EXF77338.1 - 0.0013 18.8 0.5 0.0026 17.8 0.5 1.4 1 0 0 1 1 1 1 MYND finger Pkinase_fungal PF17667.1 EXF77338.1 - 0.0019 17.0 0.0 0.0036 16.1 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Sybindin PF04099.12 EXF77339.1 - 5.9e-23 81.4 0.0 7.7e-23 81.0 0.0 1.2 1 0 0 1 1 1 1 Sybindin-like family Peroxin-3 PF04882.12 EXF77340.1 - 9.2e-173 575.5 0.2 1.1e-172 575.3 0.2 1.0 1 0 0 1 1 1 1 Peroxin-3 ATG101 PF07855.12 EXF77341.1 - 1.2e-58 197.5 0.1 1.4e-58 197.3 0.1 1.0 1 0 0 1 1 1 1 Autophagy-related protein 101 Mo-co_dimer PF03404.16 EXF77341.1 - 0.062 13.3 0.1 0.1 12.6 0.1 1.4 1 0 0 1 1 1 0 Mo-co oxidoreductase dimerisation domain Forkhead PF00250.18 EXF77342.1 - 1.8e-34 117.9 0.1 3.3e-34 117.0 0.1 1.5 1 0 0 1 1 1 1 Forkhead domain Pyridox_ox_2 PF12900.7 EXF77345.1 - 2.8e-34 118.1 0.0 1.2e-33 116.1 0.0 1.8 1 1 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Spermine_synth PF01564.17 EXF77346.1 - 6e-08 32.3 0.0 3e-06 26.8 0.0 2.3 2 0 0 2 2 2 1 Spermine/spermidine synthase domain Methyltransf_23 PF13489.6 EXF77346.1 - 9.3e-06 25.6 0.0 2.1e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF77346.1 - 0.0086 16.8 0.0 0.017 15.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF77346.1 - 0.05 14.2 0.0 0.14 12.8 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain MR_MLE_C PF13378.6 EXF77347.1 - 2.8e-57 193.8 0.0 4.3e-57 193.2 0.0 1.2 1 0 0 1 1 1 1 Enolase C-terminal domain-like MR_MLE_N PF02746.16 EXF77347.1 - 0.013 15.8 0.0 0.035 14.3 0.0 1.7 2 0 0 2 2 2 0 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain MAAL_C PF07476.11 EXF77347.1 - 0.02 14.1 0.0 0.032 13.4 0.0 1.3 1 0 0 1 1 1 0 Methylaspartate ammonia-lyase C-terminus LytTR PF04397.15 EXF77348.1 - 0.14 12.4 0.0 0.25 11.6 0.0 1.4 1 0 0 1 1 1 0 LytTr DNA-binding domain Rad10 PF03834.14 EXF77350.1 - 5.9e-47 158.4 0.0 8.2e-47 157.9 0.0 1.2 1 0 0 1 1 1 1 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) UIM PF02809.20 EXF77350.1 - 4.4 7.5 6.3 0.74 9.9 1.5 2.3 2 0 0 2 2 2 0 Ubiquitin interaction motif Glyco_hydro_47 PF01532.20 EXF77351.1 - 8.3e-142 473.3 0.0 9.4e-142 473.1 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 DNA_pol_alpha_N PF12254.8 EXF77352.1 - 0.042 13.9 0.0 0.073 13.2 0.0 1.4 1 0 0 1 1 1 0 DNA polymerase alpha subunit p180 N terminal TT_ORF2 PF02957.15 EXF77352.1 - 0.18 12.8 2.8 0.21 12.5 2.8 1.1 1 0 0 1 1 1 0 TT viral ORF2 VIT1 PF01988.19 EXF77353.1 - 1.7e-62 211.1 5.1 2.3e-62 210.6 5.1 1.2 1 0 0 1 1 1 1 VIT family SLATT_fungal PF18142.1 EXF77353.1 - 0.059 13.4 0.1 0.13 12.3 0.1 1.7 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain Fasciclin PF02469.22 EXF77354.1 - 1.1e-30 106.4 0.0 6e-16 58.8 0.0 2.2 2 0 0 2 2 2 2 Fasciclin domain EHN PF06441.12 EXF77356.1 - 7.2e-28 97.1 0.0 1.3e-27 96.2 0.0 1.5 1 0 0 1 1 1 1 Epoxide hydrolase N terminus Abhydrolase_1 PF00561.20 EXF77356.1 - 6.1e-05 22.8 0.2 0.00011 22.0 0.2 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold HET PF06985.11 EXF77357.1 - 2.1e-25 89.8 0.0 4.1e-25 88.8 0.0 1.5 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) DNA_ligase_aden PF01653.18 EXF77357.1 - 0.11 11.6 0.0 0.16 11.0 0.0 1.1 1 0 0 1 1 1 0 NAD-dependent DNA ligase adenylation domain Lactamase_B_2 PF12706.7 EXF77358.1 - 7.4e-28 97.4 0.0 2.8e-26 92.3 0.0 2.2 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 EXF77358.1 - 1.4e-08 34.8 0.0 2.5e-08 34.0 0.0 1.5 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 EXF77358.1 - 0.034 14.2 2.7 0.17 11.8 2.4 2.2 1 1 0 1 1 1 0 Metallo-beta-lactamase superfamily Ndc80_HEC PF03801.13 EXF77360.1 - 3e-61 205.6 0.3 6e-61 204.6 0.3 1.5 1 0 0 1 1 1 1 HEC/Ndc80p family Spc7 PF08317.11 EXF77360.1 - 3.9e-05 22.7 11.2 3.9e-05 22.7 11.2 3.3 4 0 0 4 4 4 2 Spc7 kinetochore protein DHR10 PF18595.1 EXF77360.1 - 6.2e-05 23.0 14.5 6.2e-05 23.0 14.5 3.4 3 0 0 3 3 3 2 Designed helical repeat protein 10 domain Filament PF00038.21 EXF77360.1 - 0.0066 16.1 41.1 0.17 11.5 14.3 3.2 2 1 0 2 2 2 2 Intermediate filament protein NPV_P10 PF05531.12 EXF77360.1 - 0.0079 16.6 8.4 1.1 9.8 0.8 4.0 2 1 1 3 3 3 2 Nucleopolyhedrovirus P10 protein Ntox28 PF15605.6 EXF77360.1 - 0.011 15.9 1.3 0.011 15.9 1.3 4.1 3 2 2 5 5 5 0 Bacterial toxin 28 FliJ PF02050.16 EXF77360.1 - 0.013 15.7 5.2 0.013 15.7 5.2 3.6 4 1 0 4 4 3 0 Flagellar FliJ protein DUF5595 PF18077.1 EXF77360.1 - 0.014 15.5 4.8 0.014 15.5 4.8 5.5 5 2 1 6 6 5 0 Domain of unknown function (DUF5595) Fungal_TACC PF12709.7 EXF77360.1 - 0.086 13.3 26.8 0.19 12.2 0.2 5.4 4 2 2 6 6 5 0 Fungal Transforming acidic coiled-coil (TACC) proteins TPR_MLP1_2 PF07926.12 EXF77360.1 - 0.092 12.8 41.9 0.033 14.2 10.8 3.8 3 1 0 3 3 3 0 TPR/MLP1/MLP2-like protein Lebercilin PF15619.6 EXF77360.1 - 0.093 12.4 34.3 0.34 10.6 10.1 3.5 3 0 0 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease FlxA PF14282.6 EXF77360.1 - 0.23 11.5 19.8 10 6.2 0.0 4.4 3 1 0 4 4 4 0 FlxA-like protein Uso1_p115_C PF04871.13 EXF77360.1 - 0.24 11.8 41.1 0.13 12.6 11.6 4.1 2 1 3 5 5 5 0 Uso1 / p115 like vesicle tethering protein, C terminal region APG6_N PF17675.1 EXF77360.1 - 0.5 10.9 51.4 0.13 12.8 13.4 4.2 2 1 2 4 4 4 0 Apg6 coiled-coil region DUF4407 PF14362.6 EXF77360.1 - 0.73 9.1 26.6 0.13 11.6 5.4 3.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4407) FlaC_arch PF05377.11 EXF77360.1 - 3.3 8.2 27.9 0.99 9.9 0.5 6.0 4 1 1 5 5 5 0 Flagella accessory protein C (FlaC) GAS PF13851.6 EXF77360.1 - 6.5 6.0 41.4 0.58 9.5 11.3 3.5 2 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding STAT_alpha PF01017.20 EXF77360.1 - 7.2 6.5 25.5 0.27 11.1 3.9 2.8 3 0 0 3 3 3 0 STAT protein, all-alpha domain V_ATPase_I PF01496.19 EXF77360.1 - 9.4 4.0 21.7 0.43 8.4 4.9 2.2 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Pex14_N PF04695.13 EXF77361.1 - 6e-35 121.2 11.3 6e-35 121.2 11.3 3.9 2 2 1 3 3 2 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Golgin_A5 PF09787.9 EXF77361.1 - 0.0015 18.1 10.2 0.0025 17.3 10.2 1.3 1 0 0 1 1 1 1 Golgin subfamily A member 5 CR6_interact PF10147.9 EXF77361.1 - 0.007 16.1 2.6 0.0097 15.6 2.6 1.3 1 0 0 1 1 1 1 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 IFT57 PF10498.9 EXF77361.1 - 0.016 14.2 5.6 0.027 13.4 5.6 1.2 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 DUF3584 PF12128.8 EXF77361.1 - 0.039 11.5 9.0 0.056 11.0 9.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Prominin PF05478.11 EXF77361.1 - 0.066 11.2 3.7 0.09 10.7 3.7 1.2 1 0 0 1 1 1 0 Prominin UPF0242 PF06785.11 EXF77361.1 - 0.075 13.1 7.4 0.12 12.4 7.4 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Plasmid_RAQPRD PF09686.10 EXF77361.1 - 0.19 12.0 3.2 0.55 10.5 1.8 2.4 1 1 1 2 2 2 0 Plasmid protein of unknown function (Plasmid_RAQPRD) HeLo PF14479.6 EXF77361.1 - 0.22 11.4 3.8 0.4 10.5 3.8 1.4 1 0 0 1 1 1 0 Prion-inhibition and propagation DUF572 PF04502.13 EXF77361.1 - 0.22 11.1 8.7 0.33 10.5 8.7 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) ISG65-75 PF11727.8 EXF77361.1 - 0.25 10.5 6.1 0.41 9.8 6.1 1.3 1 0 0 1 1 1 0 Invariant surface glycoprotein LMBR1 PF04791.16 EXF77361.1 - 0.29 10.0 0.5 0.36 9.7 0.5 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Baculo_PEP_C PF04513.12 EXF77361.1 - 0.29 11.2 8.8 2.9 7.9 2.2 2.2 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1043 PF06295.12 EXF77361.1 - 0.36 10.8 10.9 0.078 13.0 5.9 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1043) DUF948 PF06103.11 EXF77361.1 - 0.43 10.9 5.0 0.31 11.3 0.2 2.4 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF16 PF01519.16 EXF77361.1 - 0.43 11.1 9.3 4.3 7.9 4.8 2.5 2 0 0 2 2 2 0 Protein of unknown function DUF16 V_ATPase_I PF01496.19 EXF77361.1 - 0.99 7.2 3.1 1.4 6.7 3.1 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family zf-C4H2 PF10146.9 EXF77361.1 - 1.6 9.0 18.7 0.01 16.1 6.7 2.3 2 0 0 2 2 2 0 Zinc finger-containing protein TMPIT PF07851.13 EXF77361.1 - 1.8 7.7 7.0 3.2 6.9 7.0 1.4 1 0 0 1 1 1 0 TMPIT-like protein Nup88 PF10168.9 EXF77361.1 - 2.1 6.1 10.6 3.1 5.5 10.6 1.1 1 0 0 1 1 1 0 Nuclear pore component Csm1_N PF18504.1 EXF77361.1 - 5.5 7.4 11.3 2.1 8.7 6.7 2.4 1 1 1 2 2 2 0 Csm1 N-terminal domain Spc7 PF08317.11 EXF77361.1 - 7.3 5.4 14.6 19 4.0 14.5 1.4 1 1 0 1 1 1 0 Spc7 kinetochore protein Abhydrolase_3 PF07859.13 EXF77362.1 - 5.2e-49 167.0 0.0 1.5e-48 165.4 0.0 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 EXF77362.1 - 4.7e-05 22.4 0.1 0.00021 20.3 0.1 1.9 1 1 0 1 1 1 1 Steryl acetyl hydrolase Phage_base_V PF04717.12 EXF77362.1 - 0.14 12.1 0.0 0.24 11.3 0.0 1.3 1 0 0 1 1 1 0 Type VI secretion system, phage-baseplate injector FAD_binding_4 PF01565.23 EXF77363.1 - 2.5e-14 53.2 0.0 4.2e-14 52.5 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain HMG_CoA_synt_C PF08540.10 EXF77364.1 - 1.1e-98 330.4 0.8 1.9e-98 329.5 0.8 1.4 1 1 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal HMG_CoA_synt_N PF01154.17 EXF77364.1 - 4.2e-94 313.3 0.5 6e-94 312.8 0.5 1.2 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal Goodbye PF17109.5 EXF77365.1 - 1.4e-15 57.8 0.1 7.1e-15 55.5 0.0 2.3 2 0 0 2 2 2 1 fungal STAND N-terminal Goodbye domain AAA_16 PF13191.6 EXF77365.1 - 5.3e-09 36.7 1.0 1.6e-06 28.6 0.0 3.5 3 0 0 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 EXF77365.1 - 2.3e-05 24.7 0.0 0.0001 22.6 0.0 2.2 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EXF77365.1 - 0.00033 21.2 0.6 0.0015 19.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain TPR_12 PF13424.6 EXF77365.1 - 0.00039 20.6 0.1 0.054 13.8 0.0 4.1 4 1 0 4 4 3 1 Tetratricopeptide repeat KTI12 PF08433.10 EXF77365.1 - 0.0011 18.5 0.0 0.0023 17.5 0.0 1.5 1 0 0 1 1 1 1 Chromatin associated protein KTI12 NACHT PF05729.12 EXF77365.1 - 0.0013 18.7 0.2 0.0034 17.3 0.2 1.8 1 0 0 1 1 1 1 NACHT domain NB-ARC PF00931.22 EXF77365.1 - 0.0061 15.8 0.5 0.022 14.0 0.5 1.9 1 1 0 1 1 1 1 NB-ARC domain IstB_IS21 PF01695.17 EXF77365.1 - 0.015 15.0 0.0 0.052 13.3 0.0 1.8 1 0 0 1 1 1 0 IstB-like ATP binding protein TPR_MalT PF17874.1 EXF77365.1 - 0.016 14.6 0.0 0.46 9.8 0.1 2.5 1 1 1 2 2 2 0 MalT-like TPR region TPR_19 PF14559.6 EXF77365.1 - 0.044 14.3 4.0 8.1 7.0 0.1 5.2 5 0 0 5 5 5 0 Tetratricopeptide repeat NTPase_1 PF03266.15 EXF77365.1 - 0.057 13.3 0.0 0.16 11.9 0.0 1.7 1 0 0 1 1 1 0 NTPase AAA_33 PF13671.6 EXF77365.1 - 0.093 12.9 0.0 0.25 11.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 EXF77365.1 - 0.097 13.1 0.0 0.46 10.9 0.0 2.2 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) MMR_HSR1 PF01926.23 EXF77365.1 - 0.099 12.7 0.0 0.25 11.4 0.0 1.8 1 0 0 1 1 1 0 50S ribosome-binding GTPase BCS1_N PF08740.11 EXF77366.1 - 6.1e-58 195.9 5.1 8.7e-58 195.4 3.8 1.8 2 0 0 2 2 2 1 BCS1 N terminal AAA PF00004.29 EXF77366.1 - 5.4e-17 62.4 0.0 8.3e-08 32.7 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EXF77366.1 - 0.0021 18.1 0.0 0.014 15.4 0.0 2.4 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 EXF77366.1 - 0.0026 17.5 0.0 0.0056 16.4 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 EXF77366.1 - 0.0049 17.4 0.3 0.098 13.2 0.1 2.8 2 2 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EXF77366.1 - 0.007 16.8 0.7 0.029 14.7 0.1 2.3 1 1 1 2 2 2 1 AAA ATPase domain AAA_25 PF13481.6 EXF77366.1 - 0.023 14.3 0.0 0.054 13.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 EXF77366.1 - 0.032 13.6 0.0 0.07 12.5 0.0 1.5 1 0 0 1 1 1 0 KaiC Sigma70_ner PF04546.13 EXF77366.1 - 0.035 14.0 1.9 1.1 9.1 0.6 2.4 2 0 0 2 2 2 0 Sigma-70, non-essential region AAA_29 PF13555.6 EXF77366.1 - 0.071 12.9 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_28 PF13521.6 EXF77366.1 - 0.096 12.9 0.3 0.53 10.5 0.0 2.4 3 0 0 3 3 3 0 AAA domain DUF815 PF05673.13 EXF77366.1 - 0.099 11.8 0.0 0.24 10.5 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF815) IstB_IS21 PF01695.17 EXF77366.1 - 0.11 12.2 0.0 0.2 11.3 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein DUF2178 PF09946.9 EXF77366.1 - 0.14 12.4 0.1 0.28 11.3 0.1 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2178) Apt1 PF10351.9 EXF77367.1 - 2.4 6.9 6.4 3 6.6 6.4 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF4939 PF16297.5 EXF77368.1 - 1e-05 25.4 0.0 1.4e-05 24.9 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4939) PS_Dcarbxylase PF02666.15 EXF77369.1 - 2.5e-56 190.4 0.0 4.1e-56 189.7 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase C2 PF00168.30 EXF77369.1 - 1.6e-38 131.2 0.0 5.9e-18 65.1 0.0 2.8 3 0 0 3 3 3 2 C2 domain EF-hand_5 PF13202.6 EXF77369.1 - 0.0011 18.3 0.0 0.013 14.9 0.0 2.5 2 0 0 2 2 2 1 EF hand EF-hand_1 PF00036.32 EXF77369.1 - 0.0071 15.8 0.0 0.032 13.8 0.0 2.2 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 EXF77369.1 - 0.015 15.2 0.0 0.11 12.5 0.0 2.6 2 0 0 2 2 2 0 EF-hand domain EF-hand_7 PF13499.6 EXF77369.1 - 0.037 14.5 0.2 0.11 13.0 0.2 1.8 1 0 0 1 1 1 0 EF-hand domain pair ERp29 PF07749.12 EXF77369.1 - 0.4 11.6 1.9 1.4 9.9 0.6 2.5 1 1 1 2 2 2 0 Endoplasmic reticulum protein ERp29, C-terminal domain DUF1996 PF09362.10 EXF77370.1 - 1.9e-45 155.7 0.4 2.3e-45 155.4 0.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1996) LRR_6 PF13516.6 EXF77371.1 - 0.28 11.4 13.8 21 5.5 0.0 6.3 7 0 0 7 7 7 0 Leucine Rich repeat RR_TM4-6 PF06459.12 EXF77371.1 - 6.9 6.4 14.6 17 5.1 14.6 1.6 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Ribosomal_L5e PF17144.4 EXF77374.1 - 1.3e-77 259.4 0.1 1.3e-77 259.4 0.1 1.6 2 0 0 2 2 2 1 Ribosomal large subunit proteins 60S L5, and 50S L18 Ribosomal_L18_c PF14204.6 EXF77374.1 - 9.3e-35 119.5 13.7 9.3e-35 119.5 13.7 1.9 2 0 0 2 2 2 1 Ribosomal L18 C-terminal region HAD_2 PF13419.6 EXF77375.1 - 0.00026 21.1 0.0 0.00058 20.0 0.0 1.6 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Phi29_Phage_SSB PF17427.2 EXF77375.1 - 0.058 13.6 0.0 0.11 12.7 0.0 1.4 1 0 0 1 1 1 0 Phage Single-stranded DNA-binding protein Methyltransf_31 PF13847.6 EXF77376.1 - 4.8e-19 68.7 0.0 1e-18 67.6 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF77376.1 - 7.9e-18 65.0 0.1 2.6e-16 60.1 0.0 2.4 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF77376.1 - 4.5e-17 62.5 0.1 9.1e-15 55.1 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 EXF77376.1 - 3.2e-14 52.8 0.0 5.5e-14 52.1 0.0 1.4 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 EXF77376.1 - 1.7e-13 51.1 0.0 2.5e-12 47.4 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EXF77376.1 - 6.6e-09 35.8 0.0 1.2e-08 34.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 EXF77376.1 - 4e-07 30.0 0.0 8.4e-07 29.0 0.0 1.5 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) TPMT PF05724.11 EXF77376.1 - 0.00012 21.8 0.0 0.0002 21.1 0.0 1.3 1 0 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) UPF0020 PF01170.18 EXF77376.1 - 0.011 15.4 0.0 0.04 13.6 0.0 1.8 1 1 1 2 2 2 0 Putative RNA methylase family UPF0020 CheR PF01739.18 EXF77376.1 - 0.012 15.1 0.0 1.2 8.5 0.0 2.3 2 0 0 2 2 2 0 CheR methyltransferase, SAM binding domain CMAS PF02353.20 EXF77376.1 - 0.034 13.4 0.0 0.23 10.7 0.0 2.0 2 0 0 2 2 2 0 Mycolic acid cyclopropane synthetase FtsJ PF01728.19 EXF77376.1 - 0.046 13.8 0.0 0.93 9.6 0.0 2.3 2 1 0 3 3 3 0 FtsJ-like methyltransferase Methyltr_RsmB-F PF01189.17 EXF77376.1 - 0.068 12.8 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 16S rRNA methyltransferase RsmB/F Methyltransf_24 PF13578.6 EXF77376.1 - 0.081 13.9 0.0 0.25 12.4 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain Fibrillarin PF01269.17 EXF77376.1 - 0.11 11.6 0.0 0.21 10.6 0.0 1.5 1 1 0 1 1 1 0 Fibrillarin CENP-B_dimeris PF09026.10 EXF77377.1 - 0.73 10.3 5.2 1.8 9.0 5.2 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Pox_Ag35 PF03286.14 EXF77377.1 - 6.6 6.5 8.2 12 5.7 7.7 1.7 1 1 0 1 1 1 0 Pox virus Ag35 surface protein CAP59_mtransfer PF11735.8 EXF77378.1 - 2.3e-66 223.9 0.0 2.9e-66 223.6 0.0 1.1 1 0 0 1 1 1 1 Cryptococcal mannosyltransferase 1 Forkhead PF00250.18 EXF77379.1 - 1.6e-14 53.9 0.0 3.3e-14 52.9 0.0 1.5 1 0 0 1 1 1 1 Forkhead domain FHA PF00498.26 EXF77379.1 - 4.1e-05 23.9 0.1 8.5e-05 22.8 0.1 1.5 1 0 0 1 1 1 1 FHA domain Coilin_N PF15862.5 EXF77379.1 - 0.0017 18.2 0.0 0.15 11.8 0.0 3.4 3 1 0 3 3 3 1 Coilin N-terminus Yop-YscD_cpl PF16697.5 EXF77379.1 - 0.11 12.8 0.0 0.28 11.5 0.0 1.6 1 0 0 1 1 1 0 Inner membrane component of T3SS, cytoplasmic domain BBP2_2 PF10082.9 EXF77379.1 - 0.15 10.9 1.6 0.25 10.1 1.6 1.2 1 0 0 1 1 1 0 Putative beta-barrel porin 2 Spore_III_AF PF09581.10 EXF77379.1 - 8.7 6.3 7.8 22 5.0 7.8 1.7 1 0 0 1 1 1 0 Stage III sporulation protein AF (Spore_III_AF) MFS_MOT1 PF16983.5 EXF77380.1 - 1.1e-63 212.6 27.9 3e-35 121.0 10.8 2.6 2 0 0 2 2 2 2 Molybdate transporter of MFS superfamily EphA2_TM PF14575.6 EXF77382.1 - 0.95 10.4 2.7 15 6.5 0.0 2.3 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain PROL5-SMR PF15621.6 EXF77382.1 - 5.2 7.6 15.7 1.8 9.1 9.2 2.5 2 0 0 2 2 2 0 Proline-rich submaxillary gland androgen-regulated family TatD_DNase PF01026.21 EXF77383.1 - 2.7e-32 112.2 0.0 3.8e-32 111.6 0.0 1.2 1 0 0 1 1 1 1 TatD related DNase NPP1 PF05630.11 EXF77384.1 - 7e-63 212.3 0.0 8e-63 212.1 0.0 1.0 1 0 0 1 1 1 1 Necrosis inducing protein (NPP1) Na_Ca_ex PF01699.24 EXF77385.1 - 3.8e-33 114.6 29.8 1.1e-18 67.7 6.4 2.1 2 0 0 2 2 2 2 Sodium/calcium exchanger protein Equine_IAV_S2 PF06502.11 EXF77385.1 - 0.16 12.1 0.1 0.71 10.0 0.0 2.0 2 0 0 2 2 2 0 Equine infectious anaemia virus S2 protein C2 PF00168.30 EXF77387.1 - 1.6e-10 41.2 0.0 3e-10 40.3 0.0 1.4 1 0 0 1 1 1 1 C2 domain zf-BED PF02892.15 EXF77388.1 - 0.0059 16.6 0.3 0.011 15.8 0.3 1.4 1 0 0 1 1 1 1 BED zinc finger zf-C2H2 PF00096.26 EXF77388.1 - 0.027 14.9 0.7 0.027 14.9 0.7 2.2 3 0 0 3 3 3 0 Zinc finger, C2H2 type NTPase_I-T PF01931.18 EXF77389.1 - 2.8e-60 202.8 0.0 3.2e-60 202.6 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF84 Evr1_Alr PF04777.13 EXF77390.1 - 3.8e-26 91.5 0.0 5.5e-26 91.0 0.0 1.2 1 0 0 1 1 1 1 Erv1 / Alr family Proteasome PF00227.26 EXF77391.1 - 1.3e-47 161.7 0.3 1.6e-47 161.5 0.3 1.1 1 0 0 1 1 1 1 Proteasome subunit Cyclin PF08613.11 EXF77393.1 - 2.7e-40 138.4 9.9 9.8e-25 87.8 0.1 2.7 3 0 0 3 3 3 2 Cyclin FAM176 PF14851.6 EXF77393.1 - 0.77 9.4 3.2 33 4.1 2.9 2.4 2 0 0 2 2 2 0 FAM176 family Hamartin PF04388.12 EXF77393.1 - 2 7.0 15.3 3.1 6.4 15.3 1.2 1 0 0 1 1 1 0 Hamartin protein Glyoxalase PF00903.25 EXF77394.1 - 0.0085 16.3 0.1 0.028 14.6 0.1 1.8 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 EXF77394.1 - 0.056 14.2 0.0 0.069 14.0 0.0 1.2 1 0 0 1 1 1 0 Glyoxalase-like domain MFS_1 PF07690.16 EXF77395.1 - 5.9e-28 97.8 69.7 4.1e-19 68.7 34.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Pheromone PF08015.11 EXF77395.1 - 0.29 12.2 2.5 0.6 11.2 2.5 1.6 1 0 0 1 1 1 0 Fungal mating-type pheromone S-methyl_trans PF02574.16 EXF77396.1 - 1.6e-58 198.6 0.0 1.8e-58 198.4 0.0 1.0 1 0 0 1 1 1 1 Homocysteine S-methyltransferase BRX_assoc PF16627.5 EXF77398.1 - 0.23 11.6 0.9 19 5.5 0.0 2.7 2 0 0 2 2 2 0 Unstructured region between BRX_N and BRX domain His_Phos_2 PF00328.22 EXF77399.1 - 2.1e-30 106.4 0.0 3.8e-30 105.5 0.0 1.4 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) DUF5413 PF17434.2 EXF77400.1 - 0.032 14.6 0.4 0.052 13.9 0.4 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5413) UFD1 PF03152.14 EXF77401.1 - 5.3e-28 97.6 0.0 1.5e-13 50.6 0.0 3.8 4 0 0 4 4 4 3 Ubiquitin fusion degradation protein UFD1 AZUL PF16558.5 EXF77401.1 - 9.7e-07 28.9 0.0 4.2e-06 26.9 0.0 2.1 1 0 0 1 1 1 1 Amino-terminal Zinc-binding domain of ubiquitin ligase E3A F-box PF00646.33 EXF77402.1 - 0.1 12.5 0.1 0.32 10.9 0.1 1.8 1 1 1 2 2 2 0 F-box domain Cupin_1 PF00190.22 EXF77403.1 - 4.2e-22 78.4 0.9 5.4e-22 78.0 0.9 1.1 1 0 0 1 1 1 1 Cupin Cupin_2 PF07883.11 EXF77403.1 - 1.5e-05 24.6 0.0 2.4e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 Cupin domain MannoseP_isomer PF01050.18 EXF77403.1 - 0.13 12.1 0.0 0.2 11.6 0.0 1.2 1 0 0 1 1 1 0 Mannose-6-phosphate isomerase Actin PF00022.19 EXF77404.1 - 4.5e-99 331.8 0.0 4.5e-98 328.5 0.0 1.9 1 1 0 1 1 1 1 Actin DUF3915 PF13054.6 EXF77405.1 - 1.2 9.2 6.5 0.99 9.4 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3915) zf-C3HC4_3 PF13920.6 EXF77405.1 - 3.7 7.5 8.8 4.3 7.3 4.0 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Aldo_ket_red PF00248.21 EXF77406.1 - 2.3e-55 187.9 0.0 3e-55 187.5 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family CDH-cyt PF16010.5 EXF77407.1 - 3.7e-21 75.6 0.1 5.1e-21 75.2 0.1 1.2 1 0 0 1 1 1 1 Cytochrome domain of cellobiose dehydrogenase Sugar_tr PF00083.24 EXF77409.1 - 1.5e-87 294.4 19.0 1.7e-87 294.1 19.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF77409.1 - 8.5e-27 94.0 49.0 1.7e-20 73.2 26.0 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily zf-C2H2_4 PF13894.6 EXF77410.1 - 0.0043 17.8 3.6 0.013 16.3 0.2 2.9 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2 PF00096.26 EXF77410.1 - 0.0063 16.9 3.4 0.013 15.9 0.7 2.7 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-met PF12874.7 EXF77410.1 - 0.095 13.1 0.0 0.23 11.9 0.0 1.7 1 0 0 1 1 1 0 Zinc-finger of C2H2 type RhgB_N PF09284.10 EXF77411.1 - 5e-108 360.4 5.1 7.4e-108 359.8 5.1 1.3 1 0 0 1 1 1 1 Rhamnogalacturonan lyase B, N-terminal CBM-like PF14683.6 EXF77411.1 - 4.3e-44 150.3 0.0 1.3e-43 148.7 0.0 1.9 2 0 0 2 2 2 1 Polysaccharide lyase family 4, domain III fn3_3 PF14686.6 EXF77411.1 - 3e-24 84.6 6.5 1.1e-23 82.8 6.5 2.1 1 0 0 1 1 1 1 Polysaccharide lyase family 4, domain II CarboxypepD_reg PF13620.6 EXF77411.1 - 0.00054 20.2 6.1 0.00054 20.2 6.1 3.9 4 1 0 4 4 4 1 Carboxypeptidase regulatory-like domain CarbopepD_reg_2 PF13715.6 EXF77411.1 - 0.014 15.4 2.5 0.037 14.0 1.0 2.5 3 1 0 3 3 3 0 CarboxypepD_reg-like domain DUF1735 PF08522.10 EXF77411.1 - 1.3 9.6 8.4 12 6.5 0.1 3.7 5 2 0 5 5 5 0 Domain of unknown function (DUF1735) FAD_binding_3 PF01494.19 EXF77414.1 - 1.1e-18 67.6 0.0 1.4e-18 67.3 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 EXF77414.1 - 7.6e-08 32.3 0.2 0.0059 16.2 0.0 2.6 2 1 1 3 3 3 2 FAD dependent oxidoreductase Pyr_redox PF00070.27 EXF77414.1 - 1.3e-06 28.9 0.1 0.0019 18.7 0.0 2.6 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EXF77414.1 - 2.4e-06 27.0 0.2 0.022 14.0 0.1 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EXF77414.1 - 0.00063 19.9 0.1 0.0016 18.6 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain ApbA PF02558.16 EXF77414.1 - 0.11 12.1 0.2 0.22 11.2 0.2 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA FAD_binding_2 PF00890.24 EXF77414.1 - 0.15 11.2 0.1 0.3 10.1 0.0 1.5 1 1 0 1 1 1 0 FAD binding domain GrpB PF04229.14 EXF77415.1 - 4.5e-48 163.4 0.0 5.4e-48 163.2 0.0 1.1 1 0 0 1 1 1 1 GrpB protein GCIP PF13324.6 EXF77417.1 - 1.3e-23 84.0 0.1 9.5e-23 81.1 0.1 2.1 1 1 0 1 1 1 1 Grap2 and cyclin-D-interacting Sigma70_ner PF04546.13 EXF77417.1 - 0.0034 17.3 7.1 0.0068 16.3 7.1 1.5 1 0 0 1 1 1 1 Sigma-70, non-essential region Nop14 PF04147.12 EXF77417.1 - 0.0052 15.1 5.5 0.0068 14.7 5.5 1.2 1 0 0 1 1 1 1 Nop14-like family RNA_pol_3_Rpc31 PF11705.8 EXF77417.1 - 0.018 15.3 10.4 0.028 14.7 10.4 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 CDC45 PF02724.14 EXF77417.1 - 0.039 12.3 7.9 0.05 11.9 7.9 1.1 1 0 0 1 1 1 0 CDC45-like protein RRN3 PF05327.11 EXF77417.1 - 0.12 10.8 10.4 0.19 10.2 10.4 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Vfa1 PF08432.10 EXF77417.1 - 0.14 12.5 0.9 0.23 11.8 0.9 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Pox_Ag35 PF03286.14 EXF77417.1 - 0.18 11.5 8.0 5.6 6.7 8.8 2.5 2 0 0 2 2 2 0 Pox virus Ag35 surface protein DUF2457 PF10446.9 EXF77417.1 - 0.19 10.8 24.1 0.28 10.3 24.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) CNDH2_C PF16858.5 EXF77417.1 - 0.19 11.6 4.5 0.28 11.0 4.5 1.2 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term PDDEXK_6 PF04720.12 EXF77417.1 - 0.21 11.5 0.5 0.35 10.8 0.5 1.4 1 0 0 1 1 1 0 PDDEXK-like family of unknown function eIF-3c_N PF05470.12 EXF77417.1 - 0.35 9.1 4.1 0.49 8.6 4.1 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus CobT PF06213.12 EXF77417.1 - 0.47 9.8 14.3 0.77 9.1 14.3 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT TisB_toxin PF13939.6 EXF77417.1 - 0.77 9.6 2.1 1.6 8.6 2.1 1.4 1 0 0 1 1 1 0 Toxin TisB, type I toxin-antitoxin system TFB6 PF17110.5 EXF77417.1 - 0.78 9.5 10.4 2.3 7.9 8.8 2.2 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH DNA_pol_phi PF04931.13 EXF77417.1 - 1.5 6.8 22.0 2.4 6.1 22.0 1.3 1 0 0 1 1 1 0 DNA polymerase phi CENP-B_dimeris PF09026.10 EXF77417.1 - 2.1 8.8 25.0 11 6.5 25.1 2.2 2 0 0 2 2 2 0 Centromere protein B dimerisation domain YL1 PF05764.13 EXF77417.1 - 3.1 7.9 10.3 4 7.5 10.3 1.2 1 0 0 1 1 1 0 YL1 nuclear protein FAM176 PF14851.6 EXF77417.1 - 9 5.9 8.3 21 4.7 8.3 1.6 1 0 0 1 1 1 0 FAM176 family RXT2_N PF08595.11 EXF77417.1 - 9.9 6.2 11.3 20 5.2 11.3 1.5 1 0 0 1 1 1 0 RXT2-like, N-terminal PRKCSH-like PF12999.7 EXF77418.1 - 3.1e-42 144.3 5.3 1.3e-23 83.7 0.6 2.7 3 0 0 3 3 2 2 Glucosidase II beta subunit-like PRKCSH_1 PF13015.6 EXF77418.1 - 8.2e-31 106.8 4.8 5e-30 104.2 0.7 2.6 3 0 0 3 3 3 1 Glucosidase II beta subunit-like protein PRKCSH PF07915.13 EXF77418.1 - 5.6e-11 43.3 2.3 8.4e-11 42.7 0.8 2.2 2 0 0 2 2 1 1 Glucosidase II beta subunit-like protein ATG27 PF09451.10 EXF77418.1 - 0.0011 18.9 0.2 0.002 18.0 0.2 1.4 1 0 0 1 1 1 1 Autophagy-related protein 27 Snapin_Pallidin PF14712.6 EXF77418.1 - 0.0033 17.8 1.6 0.095 13.1 0.1 2.5 2 0 0 2 2 2 1 Snapin/Pallidin NPV_P10 PF05531.12 EXF77418.1 - 0.012 16.1 2.5 1.3 9.5 0.1 2.6 3 0 0 3 3 2 0 Nucleopolyhedrovirus P10 protein Mod_r PF07200.13 EXF77418.1 - 0.072 13.2 7.9 0.3 11.2 3.6 2.9 2 1 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein UPF0242 PF06785.11 EXF77418.1 - 0.18 11.9 8.6 0.14 12.2 5.1 2.1 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus HIP1_clath_bdg PF16515.5 EXF77418.1 - 0.29 11.8 11.1 0.046 14.3 3.4 2.8 2 1 1 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 SKA2 PF16740.5 EXF77418.1 - 0.33 10.7 7.2 13 5.7 0.1 3.7 3 1 1 4 4 4 0 Spindle and kinetochore-associated protein 2 Spc7 PF08317.11 EXF77418.1 - 0.34 9.7 14.5 2.6 6.8 9.2 2.6 2 1 0 2 2 2 0 Spc7 kinetochore protein DUF1664 PF07889.12 EXF77418.1 - 0.39 10.8 7.4 2 8.5 1.3 2.5 3 0 0 3 3 2 0 Protein of unknown function (DUF1664) DUF4200 PF13863.6 EXF77418.1 - 0.39 11.1 20.9 1.7 9.0 10.1 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4200) APG6_N PF17675.1 EXF77418.1 - 0.69 10.4 14.0 5.4 7.6 4.4 3.3 3 0 0 3 3 3 0 Apg6 coiled-coil region TPR_MLP1_2 PF07926.12 EXF77418.1 - 0.7 10.0 19.3 5.7 7.0 7.2 3.2 3 0 0 3 3 3 0 TPR/MLP1/MLP2-like protein IATP PF04568.12 EXF77418.1 - 0.98 9.9 9.7 4.7 7.7 4.8 2.6 2 0 0 2 2 2 0 Mitochondrial ATPase inhibitor, IATP Sec34 PF04136.15 EXF77418.1 - 1.1 9.1 4.4 31 4.4 0.0 3.0 3 0 0 3 3 3 0 Sec34-like family AAA_lid_9 PF17871.1 EXF77418.1 - 1.1 9.2 6.1 30 4.6 0.0 3.1 3 0 0 3 3 3 0 AAA lid domain DUF3086 PF11285.8 EXF77418.1 - 2 7.4 5.6 1.8 7.6 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3086) Jnk-SapK_ap_N PF09744.9 EXF77418.1 - 2.6 8.3 19.2 19 5.4 8.1 3.2 2 1 0 3 3 3 0 JNK_SAPK-associated protein-1 Phage_GP20 PF06810.11 EXF77418.1 - 2.7 7.8 14.2 0.56 10.0 0.2 3.3 2 1 1 3 3 3 0 Phage minor structural protein GP20 DUF4407 PF14362.6 EXF77418.1 - 3.5 6.9 9.9 0.66 9.3 4.8 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Ax_dynein_light PF10211.9 EXF77418.1 - 3.5 7.5 15.1 0.31 11.0 4.8 2.9 3 0 0 3 3 3 0 Axonemal dynein light chain OmpH PF03938.14 EXF77418.1 - 3.5 8.0 13.3 11 6.3 5.9 2.9 2 1 1 3 3 3 0 Outer membrane protein (OmpH-like) ABC_tran_CTD PF16326.5 EXF77418.1 - 4.9 7.5 10.5 0.62 10.3 1.9 3.3 4 0 0 4 4 3 0 ABC transporter C-terminal domain BLOC1_2 PF10046.9 EXF77418.1 - 4.9 7.5 8.0 4.6 7.6 0.9 2.8 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 ZapB PF06005.12 EXF77418.1 - 4.9 7.7 15.8 6 7.4 0.6 3.5 3 1 0 3 3 3 0 Cell division protein ZapB Filament PF00038.21 EXF77418.1 - 5 6.6 18.1 10 5.6 7.4 3.0 2 1 0 3 3 3 0 Intermediate filament protein DivIC PF04977.15 EXF77418.1 - 5.3 6.9 20.7 4.9 7.0 0.9 4.3 3 1 1 4 4 4 0 Septum formation initiator DUF1465 PF07323.12 EXF77418.1 - 5.3 6.9 6.9 3.6 7.4 0.1 2.5 1 1 0 2 2 2 0 Protein of unknown function (DUF1465) Prefoldin_2 PF01920.20 EXF77418.1 - 7.5 6.6 16.2 7.5 6.6 3.5 3.6 3 1 0 3 3 3 0 Prefoldin subunit DUF3450 PF11932.8 EXF77418.1 - 7.9 5.7 10.8 1.2 8.4 3.2 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3450) FAM184 PF15665.5 EXF77418.1 - 9 6.0 15.7 6.9 6.4 10.5 2.4 2 1 0 2 2 2 0 Family with sequence similarity 184, A and B Rtf2 PF04641.12 EXF77419.1 - 1.4e-50 172.1 1.7 1.8e-50 171.8 1.7 1.1 1 0 0 1 1 1 1 Rtf2 RING-finger Prok-RING_4 PF14447.6 EXF77419.1 - 0.00026 20.8 0.4 0.00066 19.5 0.5 1.7 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 EXF77419.1 - 0.0011 18.9 1.1 0.021 14.9 0.0 2.3 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_2 PF13639.6 EXF77419.1 - 0.0061 16.9 0.1 0.012 15.9 0.1 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 EXF77419.1 - 0.024 14.6 0.1 0.04 13.9 0.1 1.4 1 0 0 1 1 1 0 zinc-RING finger domain zf-Nse PF11789.8 EXF77419.1 - 0.032 14.1 0.1 0.13 12.1 0.3 1.9 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4_2 PF13923.6 EXF77419.1 - 0.035 14.0 0.3 0.06 13.2 0.3 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EXF77419.1 - 0.076 12.8 0.8 0.41 10.4 0.0 2.2 2 0 0 2 2 2 0 RING-like zinc finger zf-C3HC4_3 PF13920.6 EXF77419.1 - 0.082 12.8 0.2 0.16 11.8 0.2 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Zn-ribbon_8 PF09723.10 EXF77419.1 - 0.095 12.8 1.7 0.22 11.7 1.7 1.5 1 0 0 1 1 1 0 Zinc ribbon domain zf-C3HC4 PF00097.25 EXF77419.1 - 0.1 12.5 0.2 0.19 11.7 0.2 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.6 EXF77419.1 - 0.15 11.9 0.2 0.24 11.2 0.2 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain DiS_P_DiS PF06750.13 EXF77419.1 - 0.15 12.2 0.1 0.26 11.4 0.1 1.3 1 0 0 1 1 1 0 Bacterial Peptidase A24 N-terminal domain FAT PF02259.23 EXF77420.1 - 2.9e-132 441.1 7.7 7e-132 439.8 7.7 1.7 1 0 0 1 1 1 1 FAT domain DUF3385 PF11865.8 EXF77420.1 - 1.4e-77 259.1 1.2 2e-71 239.1 0.2 5.2 4 1 0 4 4 4 2 Domain of unknown function (DUF3385) PI3_PI4_kinase PF00454.27 EXF77420.1 - 9.4e-74 248.4 0.1 1.9e-73 247.4 0.1 1.5 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FRB_dom PF08771.11 EXF77420.1 - 1.8e-45 153.4 0.3 1.8e-45 153.4 0.3 3.6 4 0 0 4 4 3 1 FKBP12-rapamycin binding domain HEAT PF02985.22 EXF77420.1 - 3.8e-15 54.7 23.2 0.00042 20.3 0.0 12.0 12 0 0 12 12 12 3 HEAT repeat HEAT_2 PF13646.6 EXF77420.1 - 4.6e-15 55.8 14.5 0.00019 21.8 0.0 8.9 7 1 1 9 9 9 2 HEAT repeats FATC PF02260.20 EXF77420.1 - 2.1e-13 49.8 0.1 6.6e-13 48.2 0.1 1.9 1 0 0 1 1 1 1 FATC domain HEAT_EZ PF13513.6 EXF77420.1 - 7.7e-11 42.3 18.4 0.0047 17.4 0.2 11.4 9 3 3 12 12 11 2 HEAT-like repeat IFRD PF05004.13 EXF77420.1 - 1.3e-07 31.0 4.5 0.0019 17.4 0.9 4.5 3 1 0 4 4 4 2 Interferon-related developmental regulator (IFRD) Vac14_Fab1_bd PF12755.7 EXF77420.1 - 8.1e-06 26.4 0.6 1.3e+02 3.2 0.0 7.7 7 3 1 8 8 7 0 Vacuolar 14 Fab1-binding region CLASP_N PF12348.8 EXF77420.1 - 0.00017 21.2 3.4 13 5.3 0.0 5.9 5 1 1 6 6 6 0 CLASP N terminal Baculo_PEP_C PF04513.12 EXF77420.1 - 0.00025 21.1 0.9 0.0028 17.7 0.1 3.2 2 0 0 2 2 2 1 Baculovirus polyhedron envelope protein, PEP, C terminus Adaptin_N PF01602.20 EXF77420.1 - 0.00068 18.3 11.3 0.015 13.9 0.1 4.2 4 0 0 4 4 4 2 Adaptin N terminal region Cnd1 PF12717.7 EXF77420.1 - 0.00076 19.5 6.8 0.014 15.4 0.0 5.7 4 2 2 7 7 7 2 non-SMC mitotic condensation complex subunit 1 Sec7_N PF12783.7 EXF77420.1 - 0.036 14.0 5.8 6.2 6.7 0.0 4.9 4 1 0 4 4 4 0 Guanine nucleotide exchange factor in Golgi transport N-terminal V-ATPase_H_N PF03224.14 EXF77420.1 - 0.047 13.0 1.2 27 3.9 0.0 3.8 3 1 0 4 4 4 0 V-ATPase subunit H VirDNA-topo-I_N PF09266.10 EXF77420.1 - 0.09 12.9 0.1 0.26 11.5 0.1 1.8 1 0 0 1 1 1 0 Viral DNA topoisomerase I, N-terminal Beta-lactamase PF00144.24 EXF77421.1 - 2.8e-37 128.7 0.3 4.3e-37 128.1 0.3 1.2 1 0 0 1 1 1 1 Beta-lactamase Fungal_trans_2 PF11951.8 EXF77422.1 - 1.8e-09 36.9 0.1 6.5e-09 35.1 0.1 1.8 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF77422.1 - 4.4e-06 26.7 3.8 1e-05 25.6 3.8 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CVNH PF08881.10 EXF77423.1 - 6.9e-09 36.3 0.0 9.1e-09 35.9 0.0 1.2 1 0 0 1 1 1 1 CVNH domain DAO PF01266.24 EXF77424.1 - 4e-25 89.2 1.0 6.4e-25 88.5 1.0 1.3 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EXF77424.1 - 6.1e-05 23.1 0.1 0.0002 21.4 0.0 1.9 2 0 0 2 2 2 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 EXF77424.1 - 0.00025 21.2 0.4 0.00081 19.6 0.1 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 EXF77424.1 - 0.0016 17.8 0.0 0.0027 17.0 0.0 1.3 1 0 0 1 1 1 1 Thi4 family Pyr_redox_2 PF07992.14 EXF77424.1 - 0.0016 17.7 0.1 0.0065 15.7 0.1 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EXF77424.1 - 0.0032 16.8 0.0 2.1 7.5 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EXF77424.1 - 0.033 13.3 0.0 0.085 12.0 0.0 1.7 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) MFS_1 PF07690.16 EXF77425.1 - 5.4e-07 28.8 29.4 5.4e-07 28.8 29.4 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily UNC-93 PF05978.16 EXF77425.1 - 1.4e-06 28.1 2.3 1.4e-06 28.1 2.3 2.4 3 0 0 3 3 3 1 Ion channel regulatory protein UNC-93 Sugar_tr PF00083.24 EXF77427.1 - 1.8e-73 247.9 21.6 2.2e-73 247.7 21.6 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF77427.1 - 1.2e-15 57.3 24.7 1.6e-15 56.9 22.7 2.1 2 1 1 3 3 3 1 Major Facilitator Superfamily MFS_2 PF13347.6 EXF77427.1 - 6.7e-09 34.8 14.1 6.5e-05 21.7 3.0 2.5 2 1 0 2 2 2 2 MFS/sugar transport protein DUF3176 PF11374.8 EXF77429.1 - 1.1e-36 125.3 1.6 3.2e-36 123.8 1.6 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF3176) Neurensin PF14927.6 EXF77429.1 - 0.042 13.6 0.2 0.097 12.4 0.2 1.7 1 0 0 1 1 1 0 Neurensin Tyrosinase PF00264.20 EXF77430.1 - 1.4e-34 120.4 3.5 5.1e-34 118.5 3.5 1.8 1 1 0 1 1 1 1 Common central domain of tyrosinase Dehydratase_hem PF13816.6 EXF77431.1 - 6.9e-103 344.3 0.1 8e-103 344.1 0.1 1.0 1 0 0 1 1 1 1 Haem-containing dehydratase DUF4188 PF13826.6 EXF77431.1 - 4.6e-06 27.0 0.0 0.036 14.4 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF4188) PI-PLC-C1 PF16670.5 EXF77431.1 - 0.064 12.3 0.0 0.092 11.8 0.0 1.2 1 0 0 1 1 1 0 Phosphoinositide phospholipase C, Ca2+-dependent Lactamase_B PF00753.27 EXF77433.1 - 9.6e-11 42.0 1.8 1.5e-10 41.4 1.8 1.3 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EXF77433.1 - 6.8e-07 29.0 0.7 1.2e-06 28.2 0.6 1.4 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Methyltransf_23 PF13489.6 EXF77434.1 - 3.7e-14 52.9 0.0 7e-14 52.0 0.0 1.3 1 1 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EXF77434.1 - 1.2e-13 51.0 0.0 1.7e-13 50.5 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_25 PF13649.6 EXF77434.1 - 1.5e-13 51.2 0.0 1.3e-12 48.3 0.0 2.4 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF77434.1 - 1.7e-10 41.4 0.0 6.6e-10 39.5 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF77434.1 - 4.4e-10 39.5 0.0 7.7e-10 38.8 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF77434.1 - 8.5e-08 32.9 0.1 4.9e-07 30.4 0.0 2.2 3 0 0 3 3 3 1 Methyltransferase domain PCMT PF01135.19 EXF77434.1 - 0.00013 21.8 0.0 0.00023 21.0 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Ubie_methyltran PF01209.18 EXF77434.1 - 0.0021 17.5 0.0 0.054 12.8 0.0 2.1 1 1 1 2 2 2 1 ubiE/COQ5 methyltransferase family DUF938 PF06080.12 EXF77434.1 - 0.028 14.2 0.0 0.073 12.8 0.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF938) RrnaAD PF00398.20 EXF77434.1 - 0.14 11.2 0.0 0.19 10.8 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Pex24p PF06398.11 EXF77436.1 - 3.5e-100 335.5 0.2 4.3e-100 335.2 0.2 1.1 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin Herpes_LP PF03363.13 EXF77436.1 - 0.0082 16.0 0.6 0.017 14.9 0.6 1.6 1 0 0 1 1 1 1 Herpesvirus leader protein RBM39linker PF15519.6 EXF77437.1 - 0.22 12.6 2.0 0.41 11.8 2.0 1.5 1 0 0 1 1 1 0 linker between RRM2 and RRM3 domains in RBM39 protein DUF3176 PF11374.8 EXF77439.1 - 7.8e-34 116.1 0.1 1.9e-33 114.9 0.1 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3176) DUF4328 PF14219.6 EXF77439.1 - 0.0072 15.9 0.2 0.018 14.6 0.2 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4328) YccF PF03733.13 EXF77439.1 - 9.8 7.0 8.4 0.75 10.6 2.8 2.1 2 0 0 2 2 2 0 Inner membrane component domain FAA_hydrolase PF01557.18 EXF77440.1 - 1.9e-57 194.4 0.0 2.4e-57 194.1 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family FAD_binding_3 PF01494.19 EXF77441.1 - 1.8e-27 96.5 0.1 2.4e-27 96.1 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 EXF77441.1 - 5.1e-09 36.2 5.2 4.3e-05 23.3 4.1 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EXF77441.1 - 3e-08 33.3 0.1 0.00026 20.3 0.2 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EXF77441.1 - 7.1e-08 32.6 2.7 1.5e-07 31.5 0.5 2.6 2 1 1 3 3 3 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EXF77441.1 - 2.1e-06 27.1 1.2 3.5e-06 26.4 1.2 1.3 1 0 0 1 1 1 1 FAD binding domain Trp_halogenase PF04820.14 EXF77441.1 - 7.6e-06 25.0 0.7 0.00013 21.0 0.3 2.5 2 1 1 3 3 3 1 Tryptophan halogenase HI0933_like PF03486.14 EXF77441.1 - 2.4e-05 23.2 0.4 0.012 14.3 0.7 2.2 2 0 0 2 2 2 2 HI0933-like protein Pyr_redox PF00070.27 EXF77441.1 - 0.00039 20.9 0.0 0.0025 18.3 0.1 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EXF77441.1 - 0.0007 18.7 1.3 0.0089 15.1 1.3 2.1 1 1 0 1 1 1 1 Lycopene cyclase protein FAD_oxidored PF12831.7 EXF77441.1 - 0.00074 19.0 2.2 0.0013 18.2 2.2 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 EXF77441.1 - 0.0016 17.8 0.2 0.0034 16.7 0.2 1.5 1 0 0 1 1 1 1 Thi4 family Rossmann-like PF10727.9 EXF77441.1 - 0.0029 17.4 0.8 0.0057 16.5 0.2 1.7 2 0 0 2 2 2 1 Rossmann-like domain SE PF08491.10 EXF77441.1 - 0.0034 16.5 0.0 0.012 14.7 0.0 1.8 1 1 0 1 1 1 1 Squalene epoxidase GIDA PF01134.22 EXF77441.1 - 0.0042 16.2 0.8 0.0062 15.7 0.8 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A RHS_repeat PF05593.14 EXF77441.1 - 0.0078 16.7 0.1 0.019 15.5 0.1 1.7 1 0 0 1 1 1 1 RHS Repeat Pyr_redox_3 PF13738.6 EXF77441.1 - 0.025 13.8 0.4 0.042 13.1 0.4 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase HCV_core PF01542.18 EXF77441.1 - 0.081 13.3 1.0 18 5.8 0.3 2.6 2 0 0 2 2 2 0 Hepatitis C virus core protein Potex_coat PF06184.11 EXF77441.1 - 0.087 12.4 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 Potexvirus coat protein UDPG_MGDP_dh_N PF03721.14 EXF77441.1 - 0.089 12.4 0.1 0.15 11.6 0.1 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain ApbA PF02558.16 EXF77441.1 - 0.092 12.4 0.3 0.16 11.6 0.3 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Amino_oxidase PF01593.24 EXF77441.1 - 0.23 10.7 2.2 0.93 8.7 1.1 2.2 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase Zn_clus PF00172.18 EXF77443.1 - 1.1e-09 38.3 5.6 2e-09 37.4 5.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Cupin_2 PF07883.11 EXF77444.1 - 2.8e-24 84.6 0.1 1.5e-16 59.8 0.1 2.4 2 0 0 2 2 2 2 Cupin domain AraC_binding PF02311.19 EXF77444.1 - 3e-05 24.0 0.1 0.0046 16.9 0.1 2.3 2 0 0 2 2 2 1 AraC-like ligand binding domain Cupin_3 PF05899.12 EXF77444.1 - 0.0026 17.4 0.0 0.32 10.7 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF861) DMSP_lyase PF16867.5 EXF77444.1 - 0.014 15.0 0.0 0.028 14.0 0.0 1.5 1 0 0 1 1 1 0 Dimethlysulfonioproprionate lyase CENP-C_C PF11699.8 EXF77444.1 - 0.015 15.5 0.0 0.063 13.5 0.0 1.9 2 0 0 2 2 2 0 Mif2/CENP-C like ARD PF03079.14 EXF77444.1 - 0.08 13.1 0.0 0.21 11.7 0.0 1.6 2 0 0 2 2 2 0 ARD/ARD' family MFS_1 PF07690.16 EXF77445.1 - 1.4e-26 93.3 19.1 1.4e-26 93.3 19.1 1.7 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF77445.1 - 9.7e-07 28.0 5.9 9.7e-07 28.0 5.9 2.5 3 0 0 3 3 3 1 Sugar (and other) transporter MFS_1_like PF12832.7 EXF77445.1 - 0.027 13.3 8.7 0.034 13.0 1.8 2.6 2 0 0 2 2 2 0 MFS_1 like family DUF3270 PF11674.8 EXF77445.1 - 6.2 7.1 7.4 0.45 10.7 1.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3270) Arrestin_N PF00339.29 EXF77446.1 - 0.00016 21.8 0.0 0.00073 19.6 0.0 2.2 1 1 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Bul1_C PF04426.12 EXF77446.1 - 0.00049 19.6 0.0 0.0007 19.1 0.0 1.2 1 0 0 1 1 1 1 Bul1 C terminus Arrestin_C PF02752.22 EXF77446.1 - 0.0093 16.4 0.4 1.3 9.5 0.0 2.9 2 2 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain MFS_1 PF07690.16 EXF77447.1 - 1.2e-24 86.9 32.3 1.2e-24 86.9 32.3 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF77447.1 - 4.6e-12 45.5 5.4 4.6e-12 45.5 5.4 2.3 2 0 0 2 2 2 1 Sugar (and other) transporter UQ_con PF00179.26 EXF77448.1 - 2.1e-20 72.8 0.1 3e-20 72.3 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EXF77448.1 - 0.021 14.5 0.0 0.033 13.9 0.0 1.4 1 0 0 1 1 1 0 Prokaryotic E2 family B Bac_surface_Ag PF01103.23 EXF77449.1 - 3.9e-38 131.8 0.4 5.5e-38 131.3 0.4 1.2 1 0 0 1 1 1 1 Surface antigen FAD_binding_4 PF01565.23 EXF77450.1 - 1.5e-21 76.6 6.5 2.3e-21 76.0 6.5 1.3 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EXF77450.1 - 1.3e-07 31.6 0.0 2.5e-07 30.7 0.0 1.4 1 0 0 1 1 1 1 Berberine and berberine like RRM_1 PF00076.22 EXF77452.1 - 3.2e-29 100.5 0.0 3.3e-13 49.2 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HLH PF00010.26 EXF77452.1 - 4.1e-12 45.9 1.2 1.4e-11 44.2 1.2 1.9 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain NRBF2 PF08961.10 EXF77452.1 - 0.002 17.8 4.9 0.0041 16.8 4.9 1.4 1 0 0 1 1 1 1 Nuclear receptor-binding factor 2, autophagy regulator Rootletin PF15035.6 EXF77452.1 - 0.0042 17.1 5.4 0.0042 17.1 5.4 1.8 2 0 0 2 2 2 1 Ciliary rootlet component, centrosome cohesion KLRAQ PF10205.9 EXF77452.1 - 0.0075 16.5 0.3 0.021 15.1 0.3 1.7 1 0 0 1 1 1 1 Predicted coiled-coil domain-containing protein RRM_3 PF08777.11 EXF77452.1 - 0.039 14.0 0.1 0.54 10.3 0.0 2.4 2 0 0 2 2 2 0 RNA binding motif Phage_GPO PF05929.11 EXF77452.1 - 0.16 11.6 2.7 0.4 10.3 2.7 1.6 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase DivIC PF04977.15 EXF77452.1 - 0.21 11.4 0.9 0.93 9.3 0.9 2.1 1 0 0 1 1 1 0 Septum formation initiator GIT_CC PF16559.5 EXF77452.1 - 3.6 7.5 8.3 1.4 8.9 1.1 2.4 1 1 1 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor SymE_toxin PF08845.10 EXF77453.1 - 0.14 12.3 0.3 0.24 11.5 0.3 1.3 1 0 0 1 1 1 0 Toxin SymE, type I toxin-antitoxin system Zn_clus PF00172.18 EXF77455.1 - 2.2e-07 30.9 13.3 3.6e-07 30.2 13.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Spt20 PF12090.8 EXF77455.1 - 1.2 8.7 6.9 8 6.0 1.3 2.2 2 0 0 2 2 2 0 Spt20 family RskA PF10099.9 EXF77455.1 - 5.4 7.3 14.4 1.3 9.3 1.8 2.9 3 0 0 3 3 3 0 Anti-sigma-K factor rskA TPR_2 PF07719.17 EXF77456.1 - 5.3e-24 82.3 5.3 1.3e-06 28.1 0.1 6.0 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_1 PF00515.28 EXF77456.1 - 1.5e-23 81.6 5.3 9.3e-08 31.6 0.0 6.0 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_14 PF13428.6 EXF77456.1 - 6.2e-18 64.0 5.7 7.2e-06 26.4 0.0 5.8 3 1 2 5 5 5 3 Tetratricopeptide repeat TPR_16 PF13432.6 EXF77456.1 - 1.3e-17 64.1 9.2 2e-06 28.3 2.2 4.4 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 EXF77456.1 - 2.5e-15 55.8 8.6 2.5e-07 30.3 0.0 4.9 3 2 2 5 5 5 3 TPR repeat TPR_8 PF13181.6 EXF77456.1 - 5e-15 54.4 0.6 2e-05 24.4 0.0 5.9 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_17 PF13431.6 EXF77456.1 - 1.2e-13 50.4 4.3 0.0055 17.0 0.0 5.2 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_7 PF13176.6 EXF77456.1 - 4.5e-13 48.2 3.9 0.032 14.3 0.0 6.2 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_19 PF14559.6 EXF77456.1 - 3.7e-12 46.6 17.3 0.0003 21.2 1.2 5.3 5 1 1 6 6 5 3 Tetratricopeptide repeat TPR_6 PF13174.6 EXF77456.1 - 2.8e-09 37.0 3.9 0.25 12.1 0.2 6.4 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_9 PF13371.6 EXF77456.1 - 1.2e-08 34.9 2.7 0.015 15.4 0.5 3.6 2 2 1 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 EXF77456.1 - 1.3e-08 35.0 9.9 0.00024 21.3 0.4 4.8 3 1 3 6 6 6 4 Tetratricopeptide repeat TPR_20 PF14561.6 EXF77456.1 - 4.7e-07 30.0 10.1 0.004 17.4 0.2 4.7 4 1 1 5 5 5 3 Tetratricopeptide repeat ANAPC3 PF12895.7 EXF77456.1 - 0.0022 18.2 7.6 0.25 11.6 0.5 2.5 2 0 0 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 DUF484 PF04340.12 EXF77456.1 - 0.0046 16.7 0.0 0.011 15.4 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function, DUF484 TPR_10 PF13374.6 EXF77456.1 - 0.024 14.5 0.3 0.024 14.5 0.3 4.3 5 0 0 5 5 5 0 Tetratricopeptide repeat NatB_MDM20 PF09797.9 EXF77456.1 - 0.025 13.5 0.0 0.045 12.7 0.0 1.4 1 0 0 1 1 1 0 N-acetyltransferase B complex (NatB) non catalytic subunit TPR_15 PF13429.6 EXF77456.1 - 0.028 13.7 9.9 0.14 11.4 0.8 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF4919 PF16266.5 EXF77456.1 - 0.046 13.7 0.1 0.19 11.7 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4919) DUF1641 PF07849.11 EXF77456.1 - 0.1 12.5 0.2 0.24 11.3 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1641) TPR_21 PF09976.9 EXF77456.1 - 1.5 8.5 11.3 8.2 6.1 0.1 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat-like domain RNase_T PF00929.24 EXF77457.1 - 8.5e-06 26.4 0.0 1.3e-05 25.8 0.0 1.4 1 0 0 1 1 1 1 Exonuclease An_peroxidase PF03098.15 EXF77457.1 - 0.16 10.5 0.0 0.34 9.4 0.0 1.4 1 0 0 1 1 1 0 Animal haem peroxidase TMF_TATA_bd PF12325.8 EXF77458.1 - 0.00026 21.2 7.7 0.00026 21.2 7.7 3.2 1 1 3 4 4 4 2 TATA element modulatory factor 1 TATA binding Trimer_CC PF08954.11 EXF77458.1 - 0.0058 16.2 11.5 0.012 15.2 0.1 4.0 4 0 0 4 4 3 1 Trimerisation motif RPW8 PF05659.11 EXF77458.1 - 0.0083 15.8 8.8 0.82 9.3 0.5 3.5 2 2 1 3 3 3 2 Arabidopsis broad-spectrum mildew resistance protein RPW8 FAM72 PF14976.6 EXF77458.1 - 0.012 15.7 0.5 0.029 14.5 0.5 1.5 1 0 0 1 1 1 0 FAM72 protein Prefoldin_2 PF01920.20 EXF77458.1 - 0.013 15.4 11.5 0.6 10.1 0.1 4.0 3 1 0 3 3 3 0 Prefoldin subunit FlaC_arch PF05377.11 EXF77458.1 - 0.044 14.2 10.3 5.7 7.4 1.4 4.5 4 0 0 4 4 4 0 Flagella accessory protein C (FlaC) DASH_Dad4 PF08650.10 EXF77458.1 - 0.067 13.2 5.6 1.8 8.6 1.9 3.0 3 0 0 3 3 3 0 DASH complex subunit Dad4 YabA PF06156.13 EXF77458.1 - 0.071 13.8 19.0 0.93 10.2 1.8 4.2 1 1 3 4 4 4 0 Initiation control protein YabA Rnk_N PF14760.6 EXF77458.1 - 0.074 13.5 0.2 0.42 11.1 0.0 2.4 2 0 0 2 2 2 0 Rnk N-terminus Spectrin PF00435.21 EXF77458.1 - 0.095 13.2 12.0 0.6 10.6 0.1 3.3 3 0 0 3 3 3 0 Spectrin repeat BLOC1_2 PF10046.9 EXF77458.1 - 0.1 12.9 18.1 2.7 8.3 3.4 4.5 2 2 1 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 HopA1 PF17914.1 EXF77458.1 - 0.11 12.2 0.0 0.2 11.4 0.0 1.3 1 0 0 1 1 1 0 HopA1 effector protein family DUF1664 PF07889.12 EXF77458.1 - 1.3 9.0 15.1 0.66 10.0 1.2 3.6 1 1 3 4 4 4 0 Protein of unknown function (DUF1664) ORF6C PF10552.9 EXF77458.1 - 2.7 8.1 6.4 20 5.3 1.1 3.2 3 0 0 3 3 3 0 ORF6C domain DUF2730 PF10805.8 EXF77458.1 - 3.4 7.8 10.6 5.3 7.2 0.1 4.0 1 1 4 5 5 5 0 Protein of unknown function (DUF2730) Fib_alpha PF08702.10 EXF77458.1 - 3.4 7.8 21.7 1.1 9.4 6.1 3.4 2 1 2 4 4 3 0 Fibrinogen alpha/beta chain family LPP PF04728.13 EXF77458.1 - 3.5 8.1 12.1 14 6.2 0.3 4.4 4 1 0 4 4 3 0 Lipoprotein leucine-zipper DivIC PF04977.15 EXF77458.1 - 5.9 6.7 13.4 8.2 6.3 0.0 4.1 3 1 0 4 4 4 0 Septum formation initiator GvpK PF05121.12 EXF77458.1 - 6.9 6.8 10.6 0.46 10.6 0.2 3.3 3 1 0 3 3 3 0 Gas vesicle protein K Cnn_1N PF07989.11 EXF77458.1 - 7.8 6.7 16.2 1 9.6 7.3 3.4 3 0 0 3 3 3 0 Centrosomin N-terminal motif 1 zf-MYND PF01753.18 EXF77459.1 - 2.6e-09 37.0 11.9 5.5e-09 36.0 11.9 1.6 1 0 0 1 1 1 1 MYND finger SET PF00856.28 EXF77459.1 - 7.4e-08 33.0 0.1 3.5e-07 30.8 0.0 2.2 2 1 0 2 2 2 1 SET domain SUI1 PF01253.22 EXF77460.1 - 2.8e-27 95.0 2.1 2.8e-27 95.0 2.1 1.5 2 0 0 2 2 2 1 Translation initiation factor SUI1 SET PF00856.28 EXF77461.1 - 0.073 13.5 0.6 0.32 11.4 0.0 2.2 2 1 0 2 2 2 0 SET domain SIL1 PF16782.5 EXF77463.1 - 5.2e-10 39.0 0.0 9.8e-10 38.1 0.0 1.4 1 1 0 1 1 1 1 Nucleotide exchange factor SIL1 Ribosomal_S19 PF00203.21 EXF77464.1 - 4.8e-32 109.7 0.2 6.6e-32 109.2 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein S19 EpmC PF04315.12 EXF77464.1 - 0.14 11.9 0.0 3.8 7.2 0.0 2.1 2 0 0 2 2 2 0 Elongation factor P hydroxylase Oxidored_FMN PF00724.20 EXF77465.1 - 5.4e-83 279.1 0.0 6.9e-83 278.7 0.0 1.1 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Tim17 PF02466.19 EXF77466.1 - 2.7e-15 56.7 0.9 4.6e-15 56.0 0.9 1.3 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family DUF5518 PF17647.1 EXF77466.1 - 0.094 12.9 4.7 5.4 7.2 0.1 2.2 1 1 0 2 2 2 0 Family of unknown function (DUF5518) SGL PF08450.12 EXF77467.1 - 0.0018 17.9 0.0 0.0029 17.2 0.0 1.3 1 0 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region MoaF_C PF17409.2 EXF77468.1 - 0.065 12.9 0.0 0.17 11.6 0.0 1.6 1 0 0 1 1 1 0 MoaF C-terminal domain DUF2208 PF09973.9 EXF77468.1 - 0.86 9.2 2.1 2.4 7.7 0.5 2.4 2 0 0 2 2 2 0 Predicted membrane protein (DUF2208) BNR_2 PF13088.6 EXF77469.1 - 6.3e-21 74.9 1.0 1.1e-09 38.0 0.0 2.7 1 1 2 3 3 3 3 BNR repeat-like domain BNR PF02012.20 EXF77469.1 - 2.7e-08 32.6 17.8 0.023 14.6 0.4 5.7 5 0 0 5 5 5 4 BNR/Asp-box repeat BNR_4 PF15892.5 EXF77469.1 - 0.0042 16.5 1.1 0.2 11.0 0.8 2.0 1 1 1 2 2 2 2 BNR repeat-containing family member CHB_HEX_C PF03174.13 EXF77469.1 - 0.03 14.3 0.1 8.2 6.5 0.0 4.1 5 0 0 5 5 5 0 Chitobiase/beta-hexosaminidase C-terminal domain Mo-co_dimer PF03404.16 EXF77469.1 - 0.19 11.8 3.5 1.3 9.0 0.0 3.0 4 0 0 4 4 4 0 Mo-co oxidoreductase dimerisation domain Rrn6 PF10214.9 EXF77470.1 - 0.06 11.8 3.5 0.07 11.6 3.5 1.0 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Brix PF04427.18 EXF77471.1 - 9e-38 130.3 0.0 1.2e-37 129.9 0.0 1.1 1 0 0 1 1 1 1 Brix domain ADH_zinc_N PF00107.26 EXF77472.1 - 2.2e-11 43.8 0.5 5.1e-11 42.7 0.2 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EXF77472.1 - 0.0028 17.5 0.0 0.005 16.7 0.0 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 EXF77472.1 - 0.016 16.3 0.0 0.072 14.1 0.0 1.9 2 0 0 2 2 2 0 Zinc-binding dehydrogenase z-alpha PF02295.17 EXF77473.1 - 0.064 13.3 0.0 0.27 11.3 0.0 1.8 1 1 1 2 2 2 0 Adenosine deaminase z-alpha domain Aldo_ket_red PF00248.21 EXF77474.1 - 3e-61 207.2 0.0 3.6e-61 206.9 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family HHH_7 PF14635.6 EXF77474.1 - 0.095 13.1 0.1 0.43 10.9 0.0 1.9 1 1 1 2 2 2 0 Helix-hairpin-helix motif zf-C2H2 PF00096.26 EXF77476.1 - 0.0061 16.9 6.6 0.22 12.0 1.1 3.0 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-met PF12874.7 EXF77476.1 - 0.015 15.6 6.0 0.61 10.5 0.6 3.2 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 EXF77476.1 - 0.016 16.0 21.5 0.031 15.1 1.8 3.8 4 0 0 4 4 4 0 C2H2-type zinc finger Imm70 PF15601.6 EXF77477.1 - 0.087 12.4 0.0 0.15 11.6 0.0 1.3 1 0 0 1 1 1 0 Immunity protein 70 LSM PF01423.22 EXF77478.1 - 2.8e-21 74.9 0.1 3.3e-21 74.8 0.1 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EXF77478.1 - 7.4e-05 22.8 0.1 9e-05 22.5 0.1 1.2 1 0 0 1 1 1 1 Ataxin 2 SM domain LSM14 PF12701.7 EXF77478.1 - 0.00036 20.6 0.1 0.00044 20.3 0.1 1.1 1 0 0 1 1 1 1 Scd6-like Sm domain Hfq PF17209.3 EXF77478.1 - 0.1 12.2 0.1 0.14 11.8 0.1 1.2 1 0 0 1 1 1 0 Hfq protein Rad60-SLD PF11976.8 EXF77479.1 - 1e-21 76.5 0.1 3.5e-20 71.6 0.1 2.5 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 EXF77479.1 - 3.2e-08 33.2 0.0 1.3e-06 28.0 0.0 2.3 2 0 0 2 2 2 1 Ubiquitin family TmoB PF06234.12 EXF77479.1 - 0.0029 17.7 0.0 0.0088 16.1 0.0 1.9 1 0 0 1 1 1 1 Toluene-4-monooxygenase system protein B (TmoB) PmbA_TldD PF01523.16 EXF77479.1 - 0.0075 16.1 0.0 0.015 15.2 0.0 1.5 1 0 0 1 1 1 1 Putative modulator of DNA gyrase Ank_2 PF12796.7 EXF77480.1 - 1.3e-40 137.9 4.0 9.7e-13 48.5 0.0 9.5 7 2 2 9 9 9 6 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EXF77480.1 - 1.2e-27 92.9 4.8 0.009 16.4 0.0 12.3 12 0 0 12 12 12 6 Ankyrin repeat Ank_4 PF13637.6 EXF77480.1 - 2.7e-27 94.8 5.3 5.1e-05 23.7 0.0 10.4 10 1 1 11 11 11 6 Ankyrin repeats (many copies) Ank_5 PF13857.6 EXF77480.1 - 7.4e-23 80.3 14.4 0.011 16.0 0.0 10.1 9 1 1 10 10 10 6 Ankyrin repeats (many copies) Ank PF00023.30 EXF77480.1 - 7.7e-19 67.2 16.9 0.0014 19.0 0.0 11.7 13 0 0 13 13 13 4 Ankyrin repeat YfcL PF08891.11 EXF77480.1 - 0.1 13.0 0.0 0.4 11.1 0.0 2.0 1 0 0 1 1 1 0 YfcL protein VIT1 PF01988.19 EXF77480.1 - 0.15 11.9 0.0 0.49 10.2 0.0 1.8 1 0 0 1 1 1 0 VIT family bZIP_2 PF07716.15 EXF77482.1 - 0.00087 19.3 14.2 0.0014 18.6 14.2 1.3 1 0 0 1 1 1 1 Basic region leucine zipper DivIC PF04977.15 EXF77482.1 - 1.2 9.0 7.2 0.31 10.8 4.0 1.6 1 1 1 2 2 2 0 Septum formation initiator bZIP_1 PF00170.21 EXF77482.1 - 3.4 7.8 12.7 7.7 6.7 12.7 1.6 1 1 0 1 1 1 0 bZIP transcription factor VIT_2 PF13757.6 EXF77483.1 - 6.2 6.8 5.6 9 6.3 2.2 2.5 2 0 0 2 2 2 0 Vault protein inter-alpha-trypsin domain CDC37_N PF03234.14 EXF77484.1 - 2e-49 167.8 1.1 2e-49 167.8 1.1 3.6 3 2 1 4 4 4 1 Cdc37 N terminal kinase binding CDC37_M PF08565.11 EXF77484.1 - 3.8e-40 136.5 0.2 1e-39 135.1 0.2 1.8 1 0 0 1 1 1 1 Cdc37 Hsp90 binding domain CDC37_C PF08564.10 EXF77484.1 - 4.7e-32 110.1 0.5 4.7e-32 110.1 0.5 2.4 2 1 0 2 2 2 1 Cdc37 C terminal domain DUF2859 PF11072.8 EXF77484.1 - 0.057 13.2 0.0 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2859) MecA_N PF05223.11 EXF77484.1 - 5.2 7.4 8.4 0.43 10.9 0.2 3.2 3 1 2 5 5 5 0 NTF2-like N-terminal transpeptidase domain DUF3535 PF12054.8 EXF77485.1 - 7.7e-124 414.3 0.0 7.1e-123 411.1 0.0 2.4 3 0 0 3 3 3 1 Domain of unknown function (DUF3535) SNF2_N PF00176.23 EXF77485.1 - 2.8e-64 217.1 0.0 5.6e-64 216.1 0.0 1.5 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EXF77485.1 - 9.8e-19 67.7 0.0 2.5e-18 66.4 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HEAT PF02985.22 EXF77485.1 - 1.8e-16 58.8 1.3 0.0066 16.6 0.0 8.1 7 0 0 7 7 7 4 HEAT repeat HEAT_2 PF13646.6 EXF77485.1 - 4.1e-08 33.5 7.4 0.0001 22.6 0.0 6.3 7 0 0 7 7 7 1 HEAT repeats Vac14_Fab1_bd PF12755.7 EXF77485.1 - 8.2e-07 29.5 0.3 0.24 12.0 0.0 4.1 2 1 1 3 3 3 2 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 EXF77485.1 - 0.016 15.7 8.7 8.2 7.1 0.0 6.4 7 0 0 7 7 7 0 HEAT-like repeat RE_AccI PF09545.10 EXF77485.1 - 0.11 11.4 0.0 0.19 10.7 0.0 1.2 1 0 0 1 1 1 0 AccI restriction endonuclease ERCC3_RAD25_C PF16203.5 EXF77485.1 - 0.15 11.2 0.0 0.31 10.2 0.0 1.4 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase Adaptin_N PF01602.20 EXF77485.1 - 0.39 9.2 2.1 9 4.7 0.1 3.2 3 0 0 3 3 3 0 Adaptin N terminal region SMC_N PF02463.19 EXF77486.1 - 4.2e-62 209.5 11.3 7.9e-62 208.6 11.3 1.5 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EXF77486.1 - 1.5e-27 96.2 0.0 5e-27 94.5 0.0 2.0 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 EXF77486.1 - 7.4e-14 52.2 16.5 4.4e-09 36.6 1.7 4.2 3 2 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 EXF77486.1 - 6.5e-07 29.4 23.3 6.5e-07 29.4 23.3 4.8 2 2 0 2 2 2 1 AAA ATPase domain SbcCD_C PF13558.6 EXF77486.1 - 0.00024 21.3 0.6 0.0013 19.0 0.0 2.6 2 0 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_23 PF13476.6 EXF77486.1 - 0.00085 19.9 57.0 0.00085 19.9 57.0 7.9 2 2 2 4 4 2 1 AAA domain AAA_29 PF13555.6 EXF77486.1 - 0.0034 17.1 0.0 0.0091 15.7 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain Laminin_II PF06009.12 EXF77486.1 - 0.0059 16.6 1.6 0.0059 16.6 1.6 8.4 4 2 4 9 9 9 1 Laminin Domain II BRE1 PF08647.11 EXF77486.1 - 0.0086 16.1 4.0 0.0086 16.1 4.0 9.4 5 2 4 9 9 9 3 BRE1 E3 ubiquitin ligase BLOC1_2 PF10046.9 EXF77486.1 - 0.017 15.4 2.3 0.017 15.4 2.3 8.3 6 3 2 9 9 9 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 ABC_tran PF00005.27 EXF77486.1 - 0.55 10.8 0.0 0.55 10.8 0.0 6.7 3 2 1 5 5 4 0 ABC transporter Hydantoinase_B PF02538.14 EXF77486.1 - 0.75 8.1 2.6 1.5 7.1 2.6 1.4 1 0 0 1 1 1 0 Hydantoinase B/oxoprolinase FtsK_SpoIIIE PF01580.18 EXF77486.1 - 1.8 7.8 0.0 1.8 7.8 0.0 4.2 4 0 0 4 4 4 0 FtsK/SpoIIIE family DEAD PF00270.29 EXF77486.1 - 4 7.2 8.3 2.1 8.1 0.0 3.8 4 1 0 4 4 4 0 DEAD/DEAH box helicase E1-E2_ATPase PF00122.20 EXF77487.1 - 5.3e-37 127.1 1.7 8.6e-36 123.1 0.1 3.3 3 1 0 3 3 3 1 E1-E2 ATPase Hydrolase PF00702.26 EXF77487.1 - 1.5e-16 61.4 0.1 2.9e-16 60.4 0.1 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EXF77487.1 - 3.1e-10 39.6 0.0 8.5e-10 38.2 0.0 1.8 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EXF77487.1 - 0.0038 17.0 0.0 0.0069 16.1 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase STE PF02200.16 EXF77490.1 - 2.1e-56 189.1 0.1 3.4e-56 188.4 0.1 1.4 1 0 0 1 1 1 1 STE like transcription factor zf-C2H2 PF00096.26 EXF77490.1 - 0.00091 19.6 4.2 0.0025 18.2 4.2 1.8 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EXF77490.1 - 0.031 15.1 2.4 0.099 13.5 2.4 1.9 1 0 0 1 1 1 0 C2H2-type zinc finger DUF1899 PF08953.11 EXF77492.1 - 1.7e-33 114.3 0.0 4.1e-33 113.1 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) WD40_4 PF16300.5 EXF77492.1 - 1.6e-18 66.3 0.1 3.2e-18 65.4 0.1 1.5 1 0 0 1 1 1 1 Type of WD40 repeat WD40 PF00400.32 EXF77492.1 - 3.4e-17 62.5 5.8 4.8e-06 27.2 0.5 4.4 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EXF77492.1 - 1.4e-08 34.9 0.0 0.0017 18.6 0.0 4.0 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EXF77492.1 - 0.00055 18.7 0.2 0.59 8.7 0.1 2.2 1 1 1 2 2 2 2 Nucleoporin Nup120/160 eIF2A PF08662.11 EXF77492.1 - 0.033 14.1 0.0 0.13 12.1 0.0 1.8 1 1 1 2 2 2 0 Eukaryotic translation initiation factor eIF2A DUF16 PF01519.16 EXF77492.1 - 0.091 13.3 1.2 0.2 12.2 1.2 1.5 1 0 0 1 1 1 0 Protein of unknown function DUF16 SlyX PF04102.12 EXF77492.1 - 0.4 11.3 7.2 0.62 10.7 2.2 2.5 2 0 0 2 2 2 0 SlyX ATG16 PF08614.11 EXF77492.1 - 7.6 6.7 11.4 18 5.5 11.4 1.6 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) Anillin PF08174.11 EXF77493.1 - 1.4e-15 57.9 0.5 3.5e-15 56.7 0.0 1.9 2 0 0 2 2 2 1 Cell division protein anillin PH PF00169.29 EXF77493.1 - 5.2e-08 33.4 0.0 1.8e-07 31.6 0.0 2.0 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 EXF77493.1 - 0.28 11.6 0.7 2.3 8.7 0.0 2.6 2 0 0 2 2 2 0 Pleckstrin homology domain His_biosynth PF00977.21 EXF77494.1 - 6.1e-35 120.7 0.0 7.3e-35 120.5 0.0 1.0 1 0 0 1 1 1 1 Histidine biosynthesis protein Ribul_P_3_epim PF00834.19 EXF77494.1 - 0.059 12.8 0.0 0.093 12.1 0.0 1.3 1 0 0 1 1 1 0 Ribulose-phosphate 3 epimerase family DUF3176 PF11374.8 EXF77495.1 - 3.8e-31 107.4 0.4 1.3e-30 105.8 0.1 2.2 2 1 0 2 2 2 1 Protein of unknown function (DUF3176) Dus PF01207.17 EXF77496.1 - 1.3e-55 188.7 0.0 2.8e-55 187.6 0.0 1.5 1 1 0 1 1 1 1 Dihydrouridine synthase (Dus) Carb_anhydrase PF00194.21 EXF77498.1 - 2.5e-35 122.3 0.0 3e-35 122.0 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase UPF0164 PF03687.13 EXF77498.1 - 0.016 14.1 0.0 0.02 13.7 0.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0164) DUF3704 PF12488.8 EXF77499.1 - 0.59 9.8 2.5 1.6 8.5 2.5 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3704) AAA PF00004.29 EXF77500.1 - 4e-46 156.7 0.0 4.2e-42 143.7 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EXF77500.1 - 5.5e-09 35.7 0.0 3.1e-08 33.3 0.0 2.3 3 0 0 3 3 1 1 AAA+ lid domain AAA_16 PF13191.6 EXF77500.1 - 1.6e-08 35.1 0.1 0.0011 19.4 0.3 3.4 2 1 0 2 2 2 2 AAA ATPase domain IstB_IS21 PF01695.17 EXF77500.1 - 3e-06 27.1 0.0 4.8e-05 23.2 0.0 2.2 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_2 PF07724.14 EXF77500.1 - 7.9e-06 26.1 0.0 2.3e-05 24.6 0.0 1.8 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 EXF77500.1 - 0.00018 21.8 0.1 0.054 13.8 0.2 3.8 2 1 0 2 2 2 1 AAA domain AAA_5 PF07728.14 EXF77500.1 - 0.0017 18.3 0.0 0.0079 16.2 0.0 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 EXF77500.1 - 0.0094 16.1 5.6 0.029 14.5 0.0 3.8 4 0 0 4 4 4 1 AAA domain RuvB_N PF05496.12 EXF77500.1 - 0.0097 15.7 0.0 0.024 14.4 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 EXF77500.1 - 0.01 16.4 0.1 0.048 14.2 0.0 2.3 2 0 0 2 2 1 0 AAA domain RNA_helicase PF00910.22 EXF77500.1 - 0.012 16.0 0.0 0.077 13.4 0.0 2.3 2 0 0 2 2 2 0 RNA helicase TIP49 PF06068.13 EXF77500.1 - 0.013 14.7 0.0 0.025 13.8 0.0 1.4 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_14 PF13173.6 EXF77500.1 - 0.048 13.7 0.0 0.12 12.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 EXF77500.1 - 0.06 13.6 0.0 0.18 12.0 0.0 1.9 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 EXF77500.1 - 0.07 12.5 0.1 0.16 11.3 0.1 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Torsin PF06309.11 EXF77500.1 - 0.07 13.2 0.1 2 8.5 0.0 2.3 2 0 0 2 2 2 0 Torsin Parvo_NS1 PF01057.17 EXF77500.1 - 0.12 11.5 0.0 0.22 10.6 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_3 PF07726.11 EXF77500.1 - 0.13 12.1 0.0 0.29 11.0 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 EXF77500.1 - 0.18 11.3 0.0 0.54 9.8 0.0 1.8 1 0 0 1 1 1 0 P-loop containing dynein motor region adh_short PF00106.25 EXF77501.1 - 1.1e-33 116.4 0.4 1.3e-23 83.5 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EXF77501.1 - 3.7e-25 88.8 0.3 4.7e-23 82.0 0.3 2.1 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF77501.1 - 4.1e-06 26.8 0.0 7.7e-06 25.9 0.0 1.5 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EXF77501.1 - 0.0018 17.8 0.0 0.0033 16.9 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF1776 PF08643.10 EXF77501.1 - 0.012 15.0 0.0 0.7 9.2 0.0 2.1 2 0 0 2 2 2 0 Fungal family of unknown function (DUF1776) THF_DHG_CYH_C PF02882.19 EXF77501.1 - 0.034 13.5 0.1 0.068 12.5 0.1 1.4 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Peripla_BP_6 PF13458.6 EXF77501.1 - 0.045 13.4 0.5 0.75 9.4 0.2 2.1 2 0 0 2 2 2 0 Periplasmic binding protein NAD_binding_10 PF13460.6 EXF77501.1 - 0.047 13.6 1.4 0.75 9.7 1.5 2.3 1 1 0 1 1 1 0 NAD(P)H-binding NAD_binding_2 PF03446.15 EXF77501.1 - 0.13 12.4 0.1 0.38 10.9 0.0 1.7 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase DSBA PF01323.20 EXF77502.1 - 1.1e-13 51.4 0.0 7.9e-06 25.8 0.0 2.1 2 0 0 2 2 2 2 DSBA-like thioredoxin domain BCNT PF07572.12 EXF77503.1 - 1.6e-23 82.5 2.5 3.2e-23 81.6 2.5 1.5 1 0 0 1 1 1 1 Bucentaur or craniofacial development CDC45 PF02724.14 EXF77503.1 - 2.6 6.2 7.6 4.3 5.5 7.6 1.3 1 0 0 1 1 1 0 CDC45-like protein WD40 PF00400.32 EXF77505.1 - 2.1e-08 34.7 15.6 0.012 16.5 0.4 5.7 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EXF77505.1 - 0.0013 19.0 0.0 1.1 9.6 0.0 4.1 3 1 2 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain RNA_pol_3_Rpc31 PF11705.8 EXF77505.1 - 0.047 13.9 4.6 0.093 13.0 4.6 1.5 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 MraZ PF02381.18 EXF77505.1 - 0.071 13.1 0.0 16 5.6 0.0 2.7 2 0 0 2 2 2 0 MraZ protein, putative antitoxin-like NOA36 PF06524.12 EXF77505.1 - 0.6 9.4 3.7 0.97 8.7 3.7 1.2 1 0 0 1 1 1 0 NOA36 protein CENP-B_dimeris PF09026.10 EXF77505.1 - 0.95 9.9 8.1 2.1 8.8 8.1 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Cwf_Cwc_15 PF04889.12 EXF77505.1 - 1 9.1 9.0 0.32 10.7 5.6 1.8 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein SNF2_N PF00176.23 EXF77506.1 - 8.1e-72 241.8 0.8 8.1e-72 241.8 0.8 1.9 3 0 0 3 3 3 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EXF77506.1 - 4.7e-20 72.0 0.1 9.4e-19 67.8 0.0 3.3 3 0 0 3 3 3 1 Helicase conserved C-terminal domain Bromodomain PF00439.25 EXF77506.1 - 1.6e-18 66.5 0.1 4.2e-18 65.2 0.1 1.7 1 0 0 1 1 1 1 Bromodomain HSA PF07529.13 EXF77506.1 - 1.1e-16 60.8 13.2 1.1e-16 60.8 13.2 5.2 6 0 0 6 6 6 1 HSA SnAC PF14619.6 EXF77506.1 - 9e-14 51.8 9.2 1.2e-13 51.4 0.6 3.8 2 0 0 2 2 2 1 Snf2-ATP coupling, chromatin remodelling complex QLQ PF08880.11 EXF77506.1 - 4.4e-11 42.3 7.8 4.4e-11 42.3 7.8 2.4 2 0 0 2 2 2 1 QLQ ResIII PF04851.15 EXF77506.1 - 9.8e-11 41.9 0.0 9.8e-11 41.9 0.0 3.5 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit RBR PF17208.3 EXF77506.1 - 0.73 10.6 9.8 0.35 11.6 5.3 2.9 1 1 1 2 2 2 0 RNA binding Region HET PF06985.11 EXF77507.1 - 1.7e-22 80.3 0.1 3.4e-20 72.9 0.1 2.5 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) MA3 PF02847.17 EXF77510.1 - 3.2e-24 85.1 0.0 1.1e-23 83.4 0.0 2.0 2 0 0 2 2 2 1 MA3 domain MIF4G PF02854.19 EXF77510.1 - 4.9e-08 32.9 0.0 1.1e-07 31.7 0.0 1.6 1 0 0 1 1 1 1 MIF4G domain Cnd1 PF12717.7 EXF77510.1 - 0.051 13.6 0.2 0.12 12.4 0.2 1.5 1 0 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 CBF PF03914.17 EXF77510.1 - 0.089 12.8 1.9 0.33 11.0 1.9 1.9 1 1 0 1 1 1 0 CBF/Mak21 family DNA_pol_phi PF04931.13 EXF77510.1 - 9.6 4.2 14.0 25 2.8 14.0 1.6 1 0 0 1 1 1 0 DNA polymerase phi DPM2 PF07297.12 EXF77511.1 - 1.8e-28 98.7 1.1 2e-28 98.5 1.1 1.0 1 0 0 1 1 1 1 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) PIG-P PF08510.12 EXF77511.1 - 0.0025 17.7 0.6 0.0027 17.6 0.6 1.1 1 0 0 1 1 1 1 PIG-P DUF4229 PF14012.6 EXF77511.1 - 0.003 17.6 0.3 0.003 17.6 0.3 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF4229) LapA_dom PF06305.11 EXF77511.1 - 0.019 14.8 0.5 0.019 14.8 0.5 1.5 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain COX14 PF14880.6 EXF77511.1 - 0.023 14.5 0.7 0.47 10.3 0.0 2.0 2 0 0 2 2 2 0 Cytochrome oxidase c assembly DUF4113 PF13438.6 EXF77513.1 - 0.15 12.2 1.5 0.44 10.7 0.0 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4113) SnoaL_2 PF12680.7 EXF77514.1 - 0.0073 16.9 0.1 0.011 16.4 0.1 1.4 1 1 0 1 1 1 1 SnoaL-like domain SnoaL_4 PF13577.6 EXF77514.1 - 0.013 15.6 2.1 0.031 14.4 2.1 1.6 1 1 0 1 1 1 0 SnoaL-like domain Sugar_tr PF00083.24 EXF77515.1 - 1.7e-60 205.2 8.6 1.9e-60 205.0 8.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF77515.1 - 8.5e-05 21.6 48.4 0.00097 18.2 12.5 1.6 1 1 1 2 2 2 2 Major Facilitator Superfamily Pam17 PF08566.10 EXF77515.1 - 0.066 13.1 0.2 0.13 12.1 0.2 1.5 1 0 0 1 1 1 0 Mitochondrial import protein Pam17 DUF3336 PF11815.8 EXF77516.1 - 4.3e-33 113.9 0.2 1e-32 112.7 0.2 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Patatin PF01734.22 EXF77516.1 - 5.4e-22 79.0 0.0 1.3e-21 77.7 0.0 1.6 1 0 0 1 1 1 1 Patatin-like phospholipase CENP-H PF05837.12 EXF77516.1 - 2.2 8.7 6.9 0.75 10.2 1.9 2.2 2 0 0 2 2 2 0 Centromere protein H (CENP-H) PIG-S PF10510.9 EXF77518.1 - 4.1e-170 567.0 0.0 4.7e-170 566.8 0.0 1.0 1 0 0 1 1 1 1 Phosphatidylinositol-glycan biosynthesis class S protein AMP-binding PF00501.28 EXF77519.1 - 5.7e-74 249.2 0.0 8.5e-74 248.6 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EXF77519.1 - 2.2e-10 41.4 0.6 5.4e-10 40.1 0.1 2.0 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain Coronavirus_5 PF05528.11 EXF77519.1 - 0.1 12.6 0.0 17 5.4 0.0 3.5 4 0 0 4 4 4 0 Coronavirus gene 5 protein Abhydrolase_1 PF00561.20 EXF77520.1 - 0.033 13.8 0.0 0.069 12.8 0.1 1.5 2 0 0 2 2 2 0 alpha/beta hydrolase fold AhpC-TSA PF00578.21 EXF77521.1 - 8e-30 103.3 0.0 1e-29 102.9 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EXF77521.1 - 1.8e-12 47.2 0.0 2.4e-12 46.8 0.0 1.1 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 EXF77521.1 - 2.8e-11 43.1 0.1 5.9e-11 42.0 0.1 1.6 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin Kelch_4 PF13418.6 EXF77522.1 - 1.3e-17 63.5 0.1 2e-06 27.7 0.0 4.7 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_3 PF13415.6 EXF77522.1 - 3.8e-14 52.5 7.7 4.5e-08 33.2 0.0 6.3 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_6 PF13964.6 EXF77522.1 - 8.6e-14 51.2 4.1 0.00032 20.9 0.9 4.7 3 1 1 4 4 4 3 Kelch motif Kelch_1 PF01344.25 EXF77522.1 - 2.3e-13 49.5 0.0 0.0012 18.4 0.0 4.6 4 0 0 4 4 4 3 Kelch motif Kelch_5 PF13854.6 EXF77522.1 - 9.8e-13 47.8 1.7 4.4e-05 23.4 0.1 4.0 3 0 0 3 3 3 3 Kelch motif Kelch_2 PF07646.15 EXF77522.1 - 9.2e-08 31.8 0.2 0.00032 20.6 0.0 4.2 4 1 0 4 4 4 1 Kelch motif BTB PF00651.31 EXF77522.1 - 0.11 12.7 0.0 0.54 10.5 0.0 2.0 2 0 0 2 2 2 0 BTB/POZ domain Myb_DNA-binding PF00249.31 EXF77524.1 - 3.8e-07 30.2 0.2 2.4e-06 27.6 0.0 2.1 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EXF77524.1 - 6.7e-05 23.1 0.1 0.00017 21.7 0.1 1.8 1 1 1 2 2 2 1 Myb-like DNA-binding domain Rap1_C PF11626.8 EXF77524.1 - 0.035 14.2 0.0 0.061 13.4 0.0 1.4 1 0 0 1 1 1 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain UbiA PF01040.18 EXF77525.1 - 1.2e-58 198.4 15.5 1.2e-58 198.4 15.5 1.7 1 1 1 2 2 2 1 UbiA prenyltransferase family AXE1 PF05448.12 EXF77526.1 - 0.13 11.0 0.1 0.24 10.0 0.1 1.4 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) Abhydrolase_1 PF00561.20 EXF77527.1 - 0.012 15.3 0.0 0.022 14.4 0.0 1.5 1 0 0 1 1 1 0 alpha/beta hydrolase fold Ser_hydrolase PF06821.13 EXF77527.1 - 0.016 15.0 0.0 0.032 14.1 0.0 1.4 1 0 0 1 1 1 0 Serine hydrolase Abhydrolase_8 PF06259.12 EXF77527.1 - 0.054 13.1 0.0 0.24 11.0 0.0 1.9 2 0 0 2 2 2 0 Alpha/beta hydrolase Cupin_2 PF07883.11 EXF77528.1 - 4e-08 32.9 0.0 6.2e-08 32.2 0.0 1.3 1 0 0 1 1 1 1 Cupin domain Cupin_6 PF12852.7 EXF77528.1 - 0.0049 16.6 0.0 0.0056 16.4 0.0 1.2 1 0 0 1 1 1 1 Cupin Cupin_1 PF00190.22 EXF77528.1 - 0.0083 15.7 0.0 0.012 15.2 0.0 1.2 1 0 0 1 1 1 1 Cupin Cupin_3 PF05899.12 EXF77528.1 - 0.1 12.3 0.0 0.2 11.4 0.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF861) DUF3506 PF12014.8 EXF77529.1 - 4.4e-58 195.2 0.0 6.5e-58 194.7 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3506) F-box-like PF12937.7 EXF77529.1 - 8.8e-06 25.5 0.8 1.9e-05 24.5 0.8 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EXF77529.1 - 6.1e-05 22.8 0.1 0.00011 21.9 0.1 1.4 1 0 0 1 1 1 1 F-box domain CMAS PF02353.20 EXF77530.1 - 1.8e-17 63.6 0.1 1.8e-15 57.0 0.1 2.2 2 0 0 2 2 2 1 Mycolic acid cyclopropane synthetase Methyltransf_11 PF08241.12 EXF77530.1 - 1.9e-17 63.7 0.2 2.9e-15 56.7 0.2 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF77530.1 - 4.5e-16 59.3 0.3 7.1e-07 29.9 0.1 2.4 1 1 1 2 2 2 2 Methyltransferase domain Methyltransf_23 PF13489.6 EXF77530.1 - 5.9e-15 55.5 0.0 8.6e-15 55.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF77530.1 - 1.5e-13 51.4 0.0 8e-13 49.0 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF77530.1 - 7.8e-13 48.5 0.1 1.2e-05 25.2 0.0 2.3 1 1 1 2 2 2 2 Methyltransferase domain Ubie_methyltran PF01209.18 EXF77530.1 - 2.4e-06 27.1 0.0 9.8e-05 21.8 0.0 2.2 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family MetW PF07021.12 EXF77530.1 - 0.00095 18.8 0.0 0.029 14.0 0.1 2.2 2 0 0 2 2 2 1 Methionine biosynthesis protein MetW MTS PF05175.14 EXF77530.1 - 0.0012 18.4 0.2 0.022 14.3 0.2 2.3 2 0 0 2 2 2 1 Methyltransferase small domain FtsJ PF01728.19 EXF77530.1 - 0.0026 17.9 0.0 0.0062 16.7 0.0 1.8 1 1 0 1 1 1 1 FtsJ-like methyltransferase DOT1 PF08123.13 EXF77530.1 - 0.015 14.9 0.1 0.025 14.1 0.1 1.3 1 0 0 1 1 1 0 Histone methylation protein DOT1 TehB PF03848.14 EXF77530.1 - 0.017 14.6 0.0 0.04 13.3 0.0 1.6 2 0 0 2 2 2 0 Tellurite resistance protein TehB Methyltransf_PK PF05891.12 EXF77530.1 - 0.025 14.1 0.0 1.2 8.6 0.0 2.2 2 0 0 2 2 2 0 AdoMet dependent proline di-methyltransferase PCMT PF01135.19 EXF77530.1 - 0.051 13.3 0.1 0.36 10.5 0.2 1.9 2 0 0 2 2 2 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Ribosomal_60s PF00428.19 EXF77530.1 - 0.54 10.9 9.8 1.2 9.8 9.8 1.5 1 0 0 1 1 1 0 60s Acidic ribosomal protein Peptidase_M50B PF13398.6 EXF77531.1 - 1e-59 201.6 18.8 1.3e-59 201.3 18.8 1.1 1 0 0 1 1 1 1 Peptidase M50B-like Peptidase_M50 PF02163.22 EXF77531.1 - 0.021 14.1 0.2 0.051 12.8 0.0 1.7 2 0 0 2 2 2 0 Peptidase family M50 ACR_tran PF00873.19 EXF77531.1 - 0.055 11.1 0.4 0.085 10.5 0.4 1.3 1 0 0 1 1 1 0 AcrB/AcrD/AcrF family TMEM208_SND2 PF05620.11 EXF77531.1 - 5.7 6.7 6.3 4 7.2 0.0 2.6 3 0 0 3 3 3 0 SRP-independent targeting protein 2/TMEM208 DUF4360 PF14273.6 EXF77532.1 - 1.1e-25 90.5 0.6 1.3e-25 90.4 0.6 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4360) MFS_1 PF07690.16 EXF77533.1 - 1.3e-35 123.0 28.2 2.8e-35 121.9 28.1 1.6 1 1 1 2 2 2 1 Major Facilitator Superfamily MutS_V PF00488.21 EXF77534.1 - 3.8e-66 222.7 1.4 5.2e-66 222.3 0.4 1.8 2 0 0 2 2 2 1 MutS domain V MutS_III PF05192.18 EXF77534.1 - 1.5e-42 146.0 0.1 3.2e-42 144.9 0.1 1.6 1 0 0 1 1 1 1 MutS domain III MutS_I PF01624.20 EXF77534.1 - 3.1e-33 114.4 0.0 7.1e-33 113.2 0.0 1.7 1 0 0 1 1 1 1 MutS domain I MutS_II PF05188.17 EXF77534.1 - 1.1e-14 54.9 0.0 3.5e-14 53.3 0.0 1.9 1 0 0 1 1 1 1 MutS domain II MutS_IV PF05190.18 EXF77534.1 - 5.8e-13 49.0 0.6 1.7e-12 47.5 0.6 1.9 1 0 0 1 1 1 1 MutS family domain IV AAA_23 PF13476.6 EXF77534.1 - 0.00016 22.2 0.9 0.0032 18.0 0.0 2.9 2 0 0 2 2 2 1 AAA domain AAA_27 PF13514.6 EXF77534.1 - 0.043 13.4 0.0 0.1 12.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_21 PF13304.6 EXF77534.1 - 0.044 13.6 0.5 0.14 11.9 0.2 2.0 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EXF77534.1 - 0.11 12.2 0.0 0.28 10.9 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain MFS_1 PF07690.16 EXF77535.1 - 3.8e-39 134.6 19.3 3.8e-39 134.6 19.3 1.8 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 EXF77535.1 - 2.9e-06 26.0 4.3 4.2e-06 25.5 4.3 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) TMEM154 PF15102.6 EXF77536.1 - 8.5e-06 25.7 0.6 1.5e-05 24.9 0.6 1.5 1 1 0 1 1 1 1 TMEM154 protein family Cadherin_C_2 PF16492.5 EXF77536.1 - 0.0033 18.1 0.0 0.0094 16.7 0.0 1.9 2 0 0 2 2 2 1 Cadherin cytoplasmic C-terminal Saf_2TM PF18303.1 EXF77536.1 - 0.0053 16.4 0.0 0.01 15.4 0.0 1.4 1 1 0 1 1 1 1 SAVED-fused 2TM effector domain Rax2 PF12768.7 EXF77536.1 - 0.036 13.5 0.1 0.052 13.0 0.1 1.2 1 0 0 1 1 1 0 Cortical protein marker for cell polarity LapA_dom PF06305.11 EXF77536.1 - 0.044 13.6 0.2 0.087 12.6 0.2 1.4 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain PRIMA1 PF16101.5 EXF77536.1 - 0.06 13.4 0.0 0.1 12.6 0.0 1.4 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 FAM176 PF14851.6 EXF77536.1 - 0.065 12.9 0.0 0.1 12.2 0.0 1.3 1 0 0 1 1 1 0 FAM176 family CD34_antigen PF06365.12 EXF77536.1 - 0.07 12.7 0.0 0.091 12.3 0.0 1.3 1 0 0 1 1 1 0 CD34/Podocalyxin family Glycophorin_A PF01102.18 EXF77536.1 - 0.081 13.2 0.9 0.18 12.0 0.2 2.0 1 1 0 1 1 1 0 Glycophorin A Plasmodium_Vir PF05795.11 EXF77536.1 - 0.23 10.8 0.0 0.27 10.6 0.0 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Polysacc_synt_4 PF04669.13 EXF77537.1 - 2.6e-18 66.3 1.5 2.3e-16 59.9 1.5 2.7 1 1 0 1 1 1 1 Polysaccharide biosynthesis AChE_tetra PF08674.10 EXF77537.1 - 0.34 10.6 5.2 0.18 11.5 2.6 1.9 2 0 0 2 2 2 0 Acetylcholinesterase tetramerisation domain MFS_1 PF07690.16 EXF77539.1 - 3.7e-45 154.4 34.7 3.7e-45 154.4 34.7 1.6 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF77539.1 - 4.7e-10 38.9 7.0 4.7e-10 38.9 7.0 2.9 3 0 0 3 3 3 1 Sugar (and other) transporter PK PF00224.21 EXF77540.1 - 1.5e-171 570.0 2.7 2e-171 569.6 2.7 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.16 EXF77540.1 - 4.5e-37 126.8 0.0 1.3e-36 125.4 0.0 1.8 1 0 0 1 1 1 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.14 EXF77540.1 - 0.00049 19.3 0.5 0.002 17.3 0.2 2.0 1 1 1 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family IMPDH PF00478.25 EXF77540.1 - 0.016 14.2 0.1 0.28 10.2 0.0 2.1 2 0 0 2 2 2 0 IMP dehydrogenase / GMP reductase domain Het-C PF07217.11 EXF77542.1 - 4.6e-241 801.3 0.0 5.5e-241 801.0 0.0 1.1 1 0 0 1 1 1 1 Heterokaryon incompatibility protein Het-C TraW_N PF12477.8 EXF77542.1 - 0.53 10.3 2.3 8.7 6.4 0.7 2.4 2 0 0 2 2 2 0 Sex factor F TraW protein N terminal GATA PF00320.27 EXF77543.1 - 4.9e-16 58.0 3.5 8.2e-16 57.3 3.5 1.4 1 0 0 1 1 1 1 GATA zinc finger Perilipin PF03036.16 EXF77543.1 - 0.26 10.3 0.0 0.36 9.8 0.0 1.1 1 0 0 1 1 1 0 Perilipin family Glyco_hydro_12 PF01670.16 EXF77544.1 - 7.6e-16 58.7 9.0 1.3e-14 54.7 9.0 2.2 1 1 0 1 1 1 1 Glycosyl hydrolase family 12 Mucin PF01456.17 EXF77544.1 - 0.041 13.9 12.7 0.072 13.1 12.7 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein NADH_u_ox_C PF12853.7 EXF77545.1 - 3.9e-26 90.8 0.0 6.2e-26 90.2 0.0 1.2 1 0 0 1 1 1 1 C-terminal of NADH-ubiquinone oxidoreductase 21 kDa subunit NADH-u_ox-rdase PF10785.9 EXF77545.1 - 1.4e-21 76.9 0.2 2.8e-21 76.0 0.2 1.4 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit Swi3 PF07962.12 EXF77546.1 - 3.8e-31 106.9 0.3 6.2e-31 106.2 0.3 1.4 1 0 0 1 1 1 1 Replication Fork Protection Component Swi3 bZIP_2 PF07716.15 EXF77547.1 - 5.5e-06 26.4 17.3 1.9e-05 24.7 17.3 2.0 1 1 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 EXF77547.1 - 1.7e-05 24.8 16.1 3.8e-05 23.7 16.1 1.5 1 0 0 1 1 1 1 bZIP transcription factor bZIP_Maf PF03131.17 EXF77547.1 - 0.0075 16.8 10.9 0.018 15.5 10.9 1.6 1 0 0 1 1 1 1 bZIP Maf transcription factor NTP_transf_9 PF04248.12 EXF77548.1 - 1.3e-07 31.4 0.0 1.6e-07 31.1 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF427) Snf7 PF03357.21 EXF77549.1 - 1.9e-06 27.6 24.5 1.9e-06 27.6 24.5 1.5 1 1 0 1 1 1 1 Snf7 Ist1 PF03398.14 EXF77549.1 - 0.00061 19.8 7.3 0.0014 18.5 7.3 1.6 1 1 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway CEL_III_C PF18054.1 EXF77549.1 - 2.4 8.2 6.0 3.6 7.7 6.0 1.3 1 0 0 1 1 1 0 CEL-III C-terminal Com_YlbF PF06133.11 EXF77549.1 - 7.3 7.3 23.4 0.17 12.5 13.6 2.6 2 1 0 2 2 2 0 Control of competence regulator ComK, YlbF/YmcA DSHCT PF08148.12 EXF77550.1 - 5.1e-52 175.8 0.2 1.3e-51 174.5 0.2 1.8 1 0 0 1 1 1 1 DSHCT (NUC185) domain Transket_pyr PF02779.24 EXF77550.1 - 5.4e-45 153.2 0.0 1.5e-44 151.8 0.0 1.8 2 0 0 2 2 2 1 Transketolase, pyrimidine binding domain Ski2_N PF17911.1 EXF77550.1 - 5.1e-37 126.7 0.0 2.9e-36 124.3 0.0 2.2 2 0 0 2 2 2 1 Ski2 N-terminal region Transketolase_C PF02780.20 EXF77550.1 - 1.6e-36 124.9 0.1 3.7e-36 123.7 0.1 1.7 1 0 0 1 1 1 1 Transketolase, C-terminal domain rRNA_proc-arch PF13234.6 EXF77550.1 - 9.1e-29 101.2 0.1 1.5e-28 100.5 0.1 1.4 1 0 0 1 1 1 1 rRNA-processing arch domain DEAD PF00270.29 EXF77550.1 - 9.9e-19 67.8 0.0 2.3e-18 66.6 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EXF77550.1 - 4.9e-06 26.9 0.0 2e-05 24.9 0.0 2.2 1 1 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EXF77550.1 - 1.7e-05 24.9 0.1 0.0001 22.4 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DUF3516 PF12029.8 EXF77550.1 - 0.22 10.6 1.1 0.32 10.0 0.3 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3516) Sterol_MT_C PF08498.10 EXF77551.1 - 2.7e-28 98.0 0.4 4.9e-28 97.2 0.4 1.4 1 0 0 1 1 1 1 Sterol methyltransferase C-terminal Methyltransf_11 PF08241.12 EXF77551.1 - 1.2e-21 77.2 0.0 2.1e-21 76.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF77551.1 - 2.7e-20 72.8 0.0 5.6e-20 71.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF77551.1 - 4.6e-18 65.5 0.0 6.9e-18 64.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EXF77551.1 - 3.2e-12 46.6 0.0 5.4e-12 45.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EXF77551.1 - 1.5e-11 44.1 0.1 2.1e-11 43.6 0.1 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.18 EXF77551.1 - 4.9e-11 42.4 0.0 9.7e-11 41.4 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 EXF77551.1 - 1.4e-10 41.8 0.0 3e-10 40.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_29 PF03141.16 EXF77551.1 - 0.00055 18.6 0.0 0.00077 18.1 0.0 1.1 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase PCMT PF01135.19 EXF77551.1 - 0.0007 19.4 0.0 0.0011 18.7 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_15 PF09445.10 EXF77551.1 - 0.0012 18.5 0.0 0.0018 17.9 0.0 1.3 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase MetW PF07021.12 EXF77551.1 - 0.0018 17.9 0.0 0.0031 17.1 0.0 1.4 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW PrmA PF06325.13 EXF77551.1 - 0.0023 17.4 0.0 0.0039 16.6 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 EXF77551.1 - 0.0025 17.4 0.0 0.0045 16.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain RrnaAD PF00398.20 EXF77551.1 - 0.0039 16.3 0.0 0.0059 15.7 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_2 PF00891.18 EXF77551.1 - 0.0069 15.7 0.0 0.012 15.0 0.0 1.4 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_32 PF13679.6 EXF77551.1 - 0.011 15.7 0.0 0.02 14.9 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain TehB PF03848.14 EXF77551.1 - 0.031 13.7 0.0 0.054 12.9 0.0 1.4 1 0 0 1 1 1 0 Tellurite resistance protein TehB RRM_1 PF00076.22 EXF77552.1 - 5.1e-09 35.8 0.0 8.6e-09 35.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EXF77552.1 - 0.00047 20.0 0.0 0.00075 19.3 0.0 1.3 1 0 0 1 1 1 1 Occluded RNA-recognition motif RRM_3 PF08777.11 EXF77552.1 - 0.0073 16.3 0.0 0.015 15.3 0.0 1.5 1 0 0 1 1 1 1 RNA binding motif Nup35_RRM_2 PF14605.6 EXF77552.1 - 0.011 15.7 0.0 0.019 15.0 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Complex1_LYR PF05347.15 EXF77553.1 - 0.027 14.5 0.2 0.048 13.7 0.2 1.5 1 1 0 1 1 1 0 Complex 1 protein (LYR family) DUF1681 PF07933.14 EXF77553.1 - 0.052 13.3 0.1 0.068 12.9 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1681) SesA PF17107.5 EXF77553.1 - 0.089 13.0 0.4 0.1 12.8 0.4 1.1 1 0 0 1 1 1 0 N-terminal domain on NACHT_NTPase and P-loop NTPases RAC_head PF16717.5 EXF77554.1 - 8.5e-31 106.8 0.6 8.5e-31 106.8 0.6 3.6 3 1 1 4 4 4 1 Ribosome-associated complex head domain DnaJ PF00226.31 EXF77554.1 - 7.9e-19 67.5 1.2 7.9e-19 67.5 1.2 2.6 2 0 0 2 2 2 1 DnaJ domain TraH PF06122.11 EXF77554.1 - 0.21 10.8 5.2 0.37 10.0 5.2 1.4 1 0 0 1 1 1 0 Conjugative relaxosome accessory transposon protein PAN_4 PF14295.6 EXF77555.1 - 0.0085 16.0 1.0 0.018 14.9 1.0 1.5 1 0 0 1 1 1 1 PAN domain CFEM PF05730.11 EXF77556.1 - 7.5e-10 38.8 15.6 9.1e-10 38.5 15.6 1.1 1 0 0 1 1 1 1 CFEM domain Gamma-thionin PF00304.20 EXF77556.1 - 0.023 14.9 1.5 0.023 14.9 1.5 1.9 2 0 0 2 2 2 0 Gamma-thionin family DUF1691 PF07950.11 EXF77557.1 - 1.1e-39 135.5 8.6 2.5e-33 115.0 6.0 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF1691) DUF2955 PF11168.8 EXF77557.1 - 0.007 16.2 1.2 0.37 10.6 0.1 2.5 2 1 0 2 2 2 2 Protein of unknown function (DUF2955) zf-C2H2_jaz PF12171.8 EXF77558.1 - 5.8e-07 29.6 3.2 9.4e-07 29.0 3.2 1.4 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EXF77558.1 - 0.00048 20.4 1.0 0.00083 19.7 1.0 1.4 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 EXF77558.1 - 0.044 14.1 0.3 0.063 13.6 0.3 1.2 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 EXF77558.1 - 0.045 14.6 0.4 0.087 13.7 0.4 1.5 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2 PF00096.26 EXF77558.1 - 0.049 14.1 0.9 0.083 13.4 0.9 1.4 1 0 0 1 1 1 0 Zinc finger, C2H2 type Fungal_trans PF04082.18 EXF77559.1 - 5.1e-11 42.1 0.2 1.3e-10 40.8 0.2 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain F-box-like PF12937.7 EXF77560.1 - 5.4e-09 35.8 1.1 1.2e-08 34.7 1.1 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EXF77560.1 - 7.6e-07 28.9 2.1 1.4e-06 28.0 2.1 1.5 1 0 0 1 1 1 1 F-box domain ApbA_C PF08546.11 EXF77561.1 - 1.7e-28 99.3 0.1 3.2e-28 98.4 0.1 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.16 EXF77561.1 - 5.6e-23 81.3 0.0 1.7e-22 79.7 0.0 1.8 2 0 0 2 2 2 1 Ketopantoate reductase PanE/ApbA DMAP_binding PF06464.11 EXF77561.1 - 0.11 13.3 1.0 1.4 9.8 0.0 2.4 2 0 0 2 2 2 0 DMAP1-binding Domain SNF2_N PF00176.23 EXF77562.1 - 3.6e-65 220.0 0.0 6.5e-65 219.1 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EXF77562.1 - 3.1e-18 66.1 0.0 1e-17 64.4 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EXF77562.1 - 1.3e-09 38.3 1.8 3.2e-09 37.0 0.0 2.6 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit UPF0242 PF06785.11 EXF77562.1 - 2 8.5 7.5 5.5 7.0 7.5 1.7 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Ribosomal_S11 PF00411.19 EXF77563.1 - 1.7e-46 157.2 1.1 2.1e-46 156.9 1.1 1.1 1 0 0 1 1 1 1 Ribosomal protein S11 CBM_25 PF03423.13 EXF77563.1 - 0.089 13.1 0.0 0.16 12.2 0.0 1.4 1 0 0 1 1 1 0 Carbohydrate binding domain (family 25) Ribosomal_L30_N PF08079.12 EXF77564.1 - 1e-25 89.7 16.7 1.7e-25 89.1 16.7 1.3 1 0 0 1 1 1 1 Ribosomal L30 N-terminal domain Ribosomal_L30 PF00327.20 EXF77564.1 - 2.7e-16 59.2 2.3 2.7e-16 59.2 2.3 2.0 2 0 0 2 2 2 1 Ribosomal protein L30p/L7e DUF1943 PF09172.11 EXF77564.1 - 0.14 11.4 0.9 0.19 10.9 0.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1943) Fe-S_biosyn PF01521.20 EXF77565.1 - 9.5e-14 51.5 0.0 2.9e-12 46.8 0.0 2.1 1 1 0 1 1 1 1 Iron-sulphur cluster biosynthesis KH_7 PF17214.3 EXF77565.1 - 0.0006 19.7 0.1 0.0011 18.8 0.1 1.4 1 0 0 1 1 1 1 KH domain RSN1_TM PF13967.6 EXF77566.1 - 0.046 13.5 0.0 0.065 13.0 0.0 1.2 1 0 0 1 1 1 0 Late exocytosis, associated with Golgi transport TMEM132D_C PF15706.5 EXF77566.1 - 0.081 12.7 0.0 0.16 11.8 0.0 1.5 1 0 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term DUF4079 PF13301.6 EXF77566.1 - 0.1 12.7 0.0 0.15 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4079) DUF4006 PF13179.6 EXF77566.1 - 0.11 12.4 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF4006) DUF543 PF04418.12 EXF77567.1 - 3.7e-30 103.7 0.0 4.3e-30 103.5 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF543) Urb2 PF10441.9 EXF77568.1 - 2.7e-65 220.1 1.9 9.1e-65 218.4 0.7 2.6 2 0 0 2 2 2 1 Urb2/Npa2 family partial_CstF PF15861.5 EXF77568.1 - 0.0025 17.5 0.2 0.21 11.4 0.0 3.2 2 0 0 2 2 2 1 Partial cleavage stimulation factor domain PI3_PI4_kinase PF00454.27 EXF77569.1 - 8.5e-33 114.2 0.0 5.2e-32 111.6 0.0 2.0 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase Pik1 PF11522.8 EXF77569.1 - 4.4e-19 68.2 0.0 8.7e-19 67.2 0.0 1.5 1 0 0 1 1 1 1 Yeast phosphatidylinositol-4-OH kinase Pik1 DUF4135 PF13575.6 EXF77569.1 - 0.037 13.3 0.0 0.067 12.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) CXCR4_N PF12109.8 EXF77569.1 - 0.093 13.0 0.1 0.24 11.7 0.1 1.6 1 0 0 1 1 1 0 CXCR4 Chemokine receptor N terminal PI3Ka PF00613.20 EXF77569.1 - 0.21 10.9 0.4 0.4 10.0 0.4 1.4 1 0 0 1 1 1 0 Phosphoinositide 3-kinase family, accessory domain (PIK domain) CBFD_NFYB_HMF PF00808.23 EXF77570.1 - 2.1e-12 47.1 3.1 3.2e-12 46.5 3.1 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIIA PF03153.13 EXF77570.1 - 0.00027 21.1 36.8 0.00036 20.7 36.8 1.0 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Histone PF00125.24 EXF77570.1 - 0.083 13.2 0.0 0.083 13.2 0.0 2.7 4 0 0 4 4 4 0 Core histone H2A/H2B/H3/H4 Say1_Mug180 PF10340.9 EXF77571.1 - 6.3e-20 71.4 0.0 1.1e-13 50.8 0.0 2.3 2 1 0 2 2 2 2 Steryl acetyl hydrolase Abhydrolase_3 PF07859.13 EXF77571.1 - 7.2e-18 65.2 0.0 1.2e-17 64.5 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 EXF77571.1 - 0.0049 15.8 0.1 0.25 10.2 0.0 2.1 2 0 0 2 2 2 2 Carboxylesterase family mRNA_cap_enzyme PF01331.19 EXF77572.1 - 2.9e-58 196.9 0.9 4.7e-58 196.2 0.9 1.3 1 0 0 1 1 1 1 mRNA capping enzyme, catalytic domain mRNA_cap_C PF03919.15 EXF77572.1 - 3.1e-31 108.2 0.0 5.7e-31 107.4 0.0 1.5 1 0 0 1 1 1 1 mRNA capping enzyme, C-terminal domain DNA_ligase_A_M PF01068.21 EXF77572.1 - 1.5e-11 44.3 0.1 5.1e-08 32.8 0.1 2.2 1 1 0 1 1 1 1 ATP dependent DNA ligase domain RNA_ligase PF09414.10 EXF77572.1 - 0.00021 21.7 0.0 0.0003 21.1 0.0 1.2 1 0 0 1 1 1 1 RNA ligase PX PF00787.24 EXF77573.1 - 1.7e-19 69.9 0.0 7.2e-19 67.8 0.0 2.1 2 0 0 2 2 2 1 PX domain Vps5 PF09325.10 EXF77573.1 - 3e-13 49.9 10.7 2.4e-08 33.8 0.3 2.1 2 0 0 2 2 2 2 Vps5 C terminal like TPR_1 PF00515.28 EXF77575.1 - 5.9e-30 101.8 17.2 0.00059 19.5 0.2 11.3 11 0 0 11 11 11 9 Tetratricopeptide repeat TPR_2 PF07719.17 EXF77575.1 - 2.8e-25 86.3 31.1 0.002 18.1 0.3 12.3 13 0 0 13 13 12 8 Tetratricopeptide repeat TPR_8 PF13181.6 EXF77575.1 - 7.8e-23 78.7 23.1 0.0012 18.9 0.2 11.8 12 0 0 12 12 12 5 Tetratricopeptide repeat TPR_7 PF13176.6 EXF77575.1 - 4.6e-16 57.6 16.9 0.0011 18.8 0.1 9.9 10 0 0 10 10 9 4 Tetratricopeptide repeat TPR_12 PF13424.6 EXF77575.1 - 1.4e-13 50.9 30.5 0.0027 18.0 2.7 10.1 9 2 0 10 10 10 3 Tetratricopeptide repeat TPR_17 PF13431.6 EXF77575.1 - 1.1e-11 44.3 7.1 0.036 14.5 0.1 10.1 11 0 0 11 11 10 2 Tetratricopeptide repeat TPR_19 PF14559.6 EXF77575.1 - 3.9e-11 43.3 27.4 0.018 15.5 0.1 11.0 8 4 1 9 9 8 3 Tetratricopeptide repeat TPR_14 PF13428.6 EXF77575.1 - 3.4e-09 36.8 26.5 7 7.8 0.1 13.0 12 2 2 14 14 13 3 Tetratricopeptide repeat TPR_11 PF13414.6 EXF77575.1 - 4.4e-09 35.9 13.2 0.0069 16.0 0.0 6.8 7 0 0 7 7 7 3 TPR repeat TPR_16 PF13432.6 EXF77575.1 - 2.2e-06 28.2 22.5 0.17 12.6 0.0 8.5 8 2 2 10 10 10 3 Tetratricopeptide repeat TPR_10 PF13374.6 EXF77575.1 - 3.6e-06 26.7 15.0 0.025 14.4 0.0 8.3 10 0 0 10 10 9 2 Tetratricopeptide repeat TPR_6 PF13174.6 EXF77575.1 - 5.2e-06 26.8 18.8 1.7 9.5 0.0 11.1 13 1 0 13 13 12 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EXF77575.1 - 0.14 12.4 16.8 0.27 11.5 0.7 6.4 7 0 0 7 7 7 0 Anaphase-promoting complex, cyclosome, subunit 3 Atg14 PF10186.9 EXF77575.1 - 0.76 8.8 23.1 1.6 7.8 23.1 1.5 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Alpha-amylase PF00128.24 EXF77576.1 - 6.2e-117 390.9 3.0 6.2e-117 390.9 3.0 1.5 2 0 0 2 2 2 1 Alpha amylase, catalytic domain DUF3459 PF11941.8 EXF77576.1 - 8.3e-05 22.8 0.0 0.00023 21.5 0.0 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF3459) Malt_amylase_C PF16657.5 EXF77576.1 - 0.0083 16.2 0.0 0.022 14.9 0.0 1.7 1 0 0 1 1 1 1 Maltogenic Amylase, C-terminal domain hDGE_amylase PF14701.6 EXF77576.1 - 0.013 14.6 0.1 0.023 13.8 0.1 1.3 1 0 0 1 1 1 0 Glycogen debranching enzyme, glucanotransferase domain Glyco_hydro_114 PF03537.13 EXF77576.1 - 0.086 12.1 0.1 0.22 10.8 0.1 1.6 1 0 0 1 1 1 0 Glycoside-hydrolase family GH114 CMAS PF02353.20 EXF77577.1 - 3.3e-17 62.7 0.0 4.6e-10 39.3 0.0 3.0 2 1 1 3 3 3 3 Mycolic acid cyclopropane synthetase DUF2749 PF10907.8 EXF77578.1 - 1.7 8.9 5.7 6.3 7.0 0.1 3.6 4 0 0 4 4 4 0 Protein of unknown function (DUF2749) Use1 PF09753.9 EXF77580.1 - 1.1e-10 41.7 1.6 6.3e-10 39.2 0.0 2.1 2 0 0 2 2 2 1 Membrane fusion protein Use1 Phage_Gp23 PF10669.9 EXF77580.1 - 2.8 8.3 6.4 5.9 7.2 0.4 2.9 2 2 1 3 3 3 0 Protein gp23 (Bacteriophage A118) RhoGAP PF00620.27 EXF77581.1 - 2.9e-39 134.3 0.0 4.8e-39 133.6 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain Glyco_transf_22 PF03901.17 EXF77582.1 - 4.1e-81 273.4 3.8 8.6e-81 272.3 3.8 1.5 1 1 0 1 1 1 1 Alg9-like mannosyltransferase family AF-4 PF05110.13 EXF77582.1 - 0.0038 15.4 10.1 0.0038 15.4 10.1 2.6 3 0 0 3 3 3 1 AF-4 proto-oncoprotein Chorion_2 PF03964.15 EXF77582.1 - 6 7.8 17.9 0.41 11.5 3.1 2.7 2 0 0 2 2 2 0 Chorion family 2 Aminotran_3 PF00202.21 EXF77583.1 - 1.7e-122 409.0 0.0 1.9e-122 408.8 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Beta_elim_lyase PF01212.21 EXF77583.1 - 0.00052 19.4 0.0 0.0011 18.3 0.0 1.4 1 1 0 1 1 1 1 Beta-eliminating lyase GTP_cyclohydro2 PF00925.20 EXF77584.1 - 3.7e-61 205.5 0.0 4.9e-61 205.1 0.0 1.1 1 0 0 1 1 1 1 GTP cyclohydrolase II Hexapep PF00132.24 EXF77585.1 - 3.1e-09 36.2 7.8 2.3e-05 23.9 4.8 5.0 3 1 1 4 4 4 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 EXF77585.1 - 1e-06 28.4 0.6 0.039 13.7 0.1 3.0 3 0 0 3 3 3 2 Hexapeptide repeat of succinyl-transferase Fucokinase PF07959.12 EXF77585.1 - 0.054 12.4 0.0 0.077 11.9 0.0 1.1 1 0 0 1 1 1 0 L-fucokinase Meth_synt_2 PF01717.18 EXF77586.1 - 6e-07 29.0 0.0 6e-06 25.8 0.0 2.0 2 0 0 2 2 2 1 Cobalamin-independent synthase, Catalytic domain Meth_synt_1 PF08267.12 EXF77586.1 - 0.034 13.7 0.0 0.057 12.9 0.0 1.3 1 0 0 1 1 1 0 Cobalamin-independent synthase, N-terminal domain F-box-like PF12937.7 EXF77587.1 - 1.3e-07 31.4 5.3 2.7e-07 30.4 3.3 2.6 2 1 0 2 2 2 1 F-box-like F-box PF00646.33 EXF77587.1 - 0.049 13.5 4.0 0.82 9.6 4.0 2.7 1 1 0 1 1 1 0 F-box domain PRELI PF04707.14 EXF77588.1 - 2.4e-19 69.7 0.0 5.2e-16 58.9 0.0 2.1 2 0 0 2 2 2 2 PRELI-like family PCRF PF03462.18 EXF77589.1 - 5.5e-49 166.7 2.3 8.4e-49 166.1 0.0 2.5 3 0 0 3 3 3 1 PCRF domain RF-1 PF00472.20 EXF77589.1 - 2.4e-33 114.5 2.0 2.4e-33 114.5 2.0 2.0 2 0 0 2 2 2 1 RF-1 domain BAF1_ABF1 PF04684.13 EXF77589.1 - 0.39 9.7 3.6 2.8 6.9 0.5 2.2 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor GST_N_3 PF13417.6 EXF77591.1 - 1.1e-15 57.8 0.0 2e-15 57.0 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 EXF77591.1 - 1e-12 48.2 0.0 2.1e-12 47.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EXF77591.1 - 3e-10 40.2 0.0 4.7e-10 39.6 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EXF77591.1 - 3.3e-05 23.8 1.0 8.2e-05 22.6 1.0 1.8 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EXF77591.1 - 0.00036 20.7 0.0 0.00066 19.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Tom37 PF10568.9 EXF77591.1 - 0.0052 17.1 0.1 0.012 16.0 0.0 1.6 2 0 0 2 2 2 1 Outer mitochondrial membrane transport complex protein GST_C_3 PF14497.6 EXF77591.1 - 0.01 16.0 0.0 0.023 14.9 0.0 1.6 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 EXF77591.1 - 0.045 14.5 0.0 0.11 13.2 0.0 1.7 1 1 0 1 1 1 0 Glutathione S-transferase N-terminal domain Ifi-6-16 PF06140.13 EXF77593.1 - 1.4e-05 24.9 1.2 0.022 14.6 0.3 2.2 2 0 0 2 2 2 2 Interferon-induced 6-16 family Ifi-6-16 PF06140.13 EXF77594.1 - 3.9e-09 36.3 0.0 5.8e-09 35.7 0.0 1.2 1 0 0 1 1 1 1 Interferon-induced 6-16 family DUF883 PF05957.13 EXF77594.1 - 0.0035 17.9 0.2 0.059 14.0 0.0 2.0 2 0 0 2 2 2 1 Bacterial protein of unknown function (DUF883) Flagellar_rod PF05149.12 EXF77594.1 - 0.13 11.7 0.0 0.17 11.4 0.0 1.1 1 0 0 1 1 1 0 Paraflagellar rod protein RPA43_OB PF17875.1 EXF77595.1 - 1.1e-34 119.7 0.1 1.1e-34 119.7 0.1 3.9 2 1 0 2 2 2 1 RPA43 OB domain in RNA Pol I SHS2_Rpb7-N PF03876.17 EXF77595.1 - 3.5e-06 27.3 0.0 6.9e-06 26.3 0.0 1.5 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 BRD4_CDT PF17105.5 EXF77595.1 - 0.16 11.6 1.4 0.52 9.9 1.4 1.9 1 0 0 1 1 1 0 C-terminal domain of bromodomain protein 4 Ndc1_Nup PF09531.10 EXF77595.1 - 0.96 8.1 9.4 1.2 7.7 9.4 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Macoilin PF09726.9 EXF77595.1 - 6.6 5.2 15.5 8.8 4.7 15.5 1.1 1 0 0 1 1 1 0 Macoilin family NmrA PF05368.13 EXF77596.1 - 2.5e-33 115.6 0.3 3.2e-33 115.2 0.3 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EXF77596.1 - 6.7e-11 42.4 0.0 2.7e-10 40.5 0.0 2.1 1 1 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 EXF77596.1 - 8.6e-05 21.7 0.1 0.00013 21.1 0.1 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 EXF77596.1 - 0.0002 20.9 0.0 0.00031 20.2 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Semialdhyde_dh PF01118.24 EXF77596.1 - 0.00035 21.0 0.2 0.0019 18.7 0.0 2.1 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain Epimerase PF01370.21 EXF77596.1 - 0.00039 20.0 0.0 0.00069 19.1 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family PTH2 PF01981.16 EXF77596.1 - 0.0017 18.6 0.1 1.5 9.1 0.1 2.4 2 0 0 2 2 2 2 Peptidyl-tRNA hydrolase PTH2 KR PF08659.10 EXF77596.1 - 0.011 15.7 0.0 0.028 14.4 0.0 1.6 2 0 0 2 2 2 0 KR domain Glu_dehyd_C PF16912.5 EXF77596.1 - 0.012 15.1 0.0 0.047 13.2 0.0 1.8 2 0 0 2 2 2 0 Glucose dehydrogenase C-terminus TrkA_N PF02254.18 EXF77596.1 - 0.017 15.4 0.1 0.04 14.2 0.1 1.6 1 0 0 1 1 1 0 TrkA-N domain Polysacc_synt_2 PF02719.15 EXF77596.1 - 0.11 11.6 0.0 0.17 11.0 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein DUF5406 PF17400.2 EXF77596.1 - 0.13 12.7 0.0 0.29 11.6 0.0 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5406) Ldh_1_N PF00056.23 EXF77596.1 - 0.14 12.2 0.1 0.23 11.5 0.1 1.3 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain Asp_Glu_race PF01177.22 EXF77597.1 - 0.00035 20.5 0.0 0.0012 18.7 0.0 1.9 1 1 0 1 1 1 1 Asp/Glu/Hydantoin racemase Actin PF00022.19 EXF77598.1 - 4.6e-111 371.3 0.0 2.9e-110 368.7 0.0 1.8 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EXF77598.1 - 0.027 13.3 0.0 0.22 10.3 0.0 2.1 1 1 0 1 1 1 0 MreB/Mbl protein Actin_micro PF17003.5 EXF77598.1 - 0.049 12.8 0.0 0.28 10.3 0.0 2.0 2 0 0 2 2 2 0 Putative actin-like family Pkinase PF00069.25 EXF77599.1 - 2.1e-63 214.2 0.0 2.7e-63 213.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF77599.1 - 8.3e-31 107.2 0.0 1.2e-30 106.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EXF77599.1 - 0.048 13.0 0.0 0.081 12.2 0.0 1.3 1 0 0 1 1 1 0 Kinase-like APH PF01636.23 EXF77599.1 - 0.11 12.4 0.0 0.4 10.6 0.0 1.7 1 1 0 2 2 2 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EXF77599.1 - 0.12 11.3 0.0 0.17 10.8 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Ribosomal_S24e PF01282.19 EXF77600.1 - 8.4e-35 118.6 0.0 1.6e-34 117.7 0.0 1.5 1 1 0 1 1 1 1 Ribosomal protein S24e Methyltransf_16 PF10294.9 EXF77601.1 - 3.4e-19 69.2 0.0 5.2e-19 68.6 0.0 1.2 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_25 PF13649.6 EXF77601.1 - 0.00043 20.9 0.0 0.001 19.7 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EXF77601.1 - 0.00065 19.6 0.0 0.00098 19.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EXF77601.1 - 0.0014 18.1 0.0 0.0021 17.5 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) PCMT PF01135.19 EXF77601.1 - 0.0019 18.0 0.0 0.004 16.9 0.0 1.5 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.14 EXF77601.1 - 0.0076 15.8 0.0 0.012 15.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_12 PF08242.12 EXF77601.1 - 0.016 15.9 0.0 0.032 15.0 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Met_10 PF02475.16 EXF77601.1 - 0.056 13.2 0.0 0.1 12.3 0.0 1.3 1 0 0 1 1 1 0 Met-10+ like-protein Methyltransf_18 PF12847.7 EXF77601.1 - 0.071 13.0 0.0 0.14 12.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 EXF77601.1 - 0.1 12.4 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain DUF938 PF06080.12 EXF77601.1 - 0.12 12.2 0.0 0.18 11.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF938) Activator_LAG-3 PF11498.8 EXF77602.1 - 0.029 13.3 0.4 0.036 13.1 0.4 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Pro_isomerase PF00160.21 EXF77603.1 - 6.6e-34 117.5 0.0 1.2e-33 116.7 0.0 1.4 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RRM_1 PF00076.22 EXF77603.1 - 2.8e-15 55.9 0.0 4.7e-15 55.2 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RR_TM4-6 PF06459.12 EXF77603.1 - 2.3 8.0 4.9 4.4 7.1 4.9 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Avl9 PF09794.9 EXF77605.1 - 4.3e-145 483.2 0.0 5.4e-145 482.8 0.0 1.1 1 0 0 1 1 1 1 Transport protein Avl9 SPA PF08616.10 EXF77605.1 - 4e-07 30.0 0.1 0.00035 20.5 0.0 2.4 2 0 0 2 2 2 2 Stabilization of polarity axis DUF2347 PF09804.9 EXF77605.1 - 6.1e-07 29.3 1.0 2.8e-05 23.8 0.1 3.3 2 1 0 2 2 2 1 Uncharacterized conserved protein (DUF2347) Pkinase PF00069.25 EXF77606.1 - 1.9e-68 230.7 0.0 2.5e-68 230.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF77606.1 - 3.5e-32 111.7 0.0 4.7e-32 111.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EXF77606.1 - 9.2e-06 24.8 0.1 1.3e-05 24.4 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EXF77606.1 - 3.3e-05 23.4 0.1 0.0001 21.7 0.1 1.7 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EXF77606.1 - 0.00043 20.3 0.1 0.0018 18.3 0.0 1.8 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 EXF77606.1 - 0.00083 18.7 0.0 0.05 12.9 0.0 2.2 1 1 1 2 2 2 1 Kinase-like RIO1 PF01163.22 EXF77606.1 - 0.021 14.4 0.0 0.037 13.6 0.0 1.4 1 0 0 1 1 1 0 RIO1 family FTA2 PF13095.6 EXF77606.1 - 0.024 14.3 0.0 0.046 13.3 0.0 1.5 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Phosphorylase PF00343.20 EXF77607.1 - 0 1054.7 0.0 0 1054.5 0.0 1.0 1 0 0 1 1 1 1 Carbohydrate phosphorylase Gp58 PF07902.11 EXF77607.1 - 0.085 11.1 0.0 0.12 10.7 0.0 1.2 1 0 0 1 1 1 0 gp58-like protein ABC_tran PF00005.27 EXF77609.1 - 8.6e-48 162.3 0.0 2.8e-23 82.9 0.0 2.7 3 0 0 3 3 2 2 ABC transporter ABC_tran_Xtn PF12848.7 EXF77609.1 - 1.2e-19 70.1 0.8 1.2e-19 70.1 0.8 2.4 2 0 0 2 2 1 1 ABC transporter AAA_21 PF13304.6 EXF77609.1 - 4.3e-19 69.4 0.9 0.00011 22.1 0.0 4.2 3 1 0 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EXF77609.1 - 4.8e-12 45.8 0.1 0.00013 21.4 0.1 4.5 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EXF77609.1 - 1.7e-09 38.5 0.6 0.0095 16.5 0.0 3.5 3 0 0 3 3 3 2 AAA domain AAA_29 PF13555.6 EXF77609.1 - 3.9e-09 36.1 0.0 0.003 17.3 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_15 PF13175.6 EXF77609.1 - 1.7e-06 28.0 0.2 0.045 13.5 0.0 3.0 3 1 0 3 3 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 EXF77609.1 - 1.7e-06 28.1 0.0 0.0049 16.8 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EXF77609.1 - 3.2e-06 27.2 0.0 0.016 15.3 0.0 3.2 3 0 0 3 3 3 2 50S ribosome-binding GTPase AAA_16 PF13191.6 EXF77609.1 - 4.3e-06 27.2 0.0 0.018 15.4 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 EXF77609.1 - 9.2e-06 26.0 0.1 0.054 13.8 0.1 2.6 2 0 0 2 2 2 2 AAA domain AAA_28 PF13521.6 EXF77609.1 - 2.4e-05 24.7 0.0 0.014 15.7 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 EXF77609.1 - 4.2e-05 24.0 0.0 0.4 11.1 0.0 2.9 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 EXF77609.1 - 5.3e-05 23.8 0.0 0.27 11.8 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.14 EXF77609.1 - 9.9e-05 22.4 0.2 0.47 10.5 0.0 2.5 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) NACHT PF05729.12 EXF77609.1 - 0.0001 22.3 0.1 0.2 11.6 0.0 2.6 2 0 0 2 2 2 2 NACHT domain AAA_27 PF13514.6 EXF77609.1 - 0.00029 20.5 0.0 0.066 12.8 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EXF77609.1 - 0.00035 20.7 0.0 0.49 10.6 0.1 2.8 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 EXF77609.1 - 0.0004 20.7 0.0 1.6 9.2 0.0 2.8 2 0 0 2 2 2 2 RNA helicase AAA_14 PF13173.6 EXF77609.1 - 0.0011 19.0 0.0 1.9 8.6 0.0 2.7 2 0 0 2 2 2 2 AAA domain Roc PF08477.13 EXF77609.1 - 0.0013 19.0 0.0 2.1 8.6 0.1 3.0 2 1 1 3 3 2 1 Ras of Complex, Roc, domain of DAPkinase AAA_24 PF13479.6 EXF77609.1 - 0.0025 17.6 1.7 1.9 8.2 0.0 3.6 4 0 0 4 4 4 1 AAA domain AAA_25 PF13481.6 EXF77609.1 - 0.0041 16.7 0.0 0.68 9.5 0.0 2.9 3 0 0 3 3 3 1 AAA domain NB-ARC PF00931.22 EXF77609.1 - 0.0043 16.3 0.0 6.5 5.8 0.0 3.1 3 0 0 3 3 3 0 NB-ARC domain Dynamin_N PF00350.23 EXF77609.1 - 0.006 16.6 0.5 8.2 6.5 0.0 3.4 3 1 0 4 4 4 0 Dynamin family DUF2813 PF11398.8 EXF77609.1 - 0.011 15.0 0.0 2.6 7.2 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2813) AAA_17 PF13207.6 EXF77609.1 - 0.012 16.1 0.0 4.2 7.8 0.0 2.9 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 EXF77609.1 - 0.02 14.4 0.0 1.9 8.0 0.0 2.5 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_30 PF13604.6 EXF77609.1 - 0.023 14.4 0.2 2.8 7.6 0.1 2.9 2 1 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 EXF77609.1 - 0.044 13.7 0.0 4.9 7.0 0.0 2.5 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea MCM PF00493.23 EXF77609.1 - 0.048 12.7 0.0 7 5.7 0.0 2.4 2 0 0 2 2 2 0 MCM P-loop domain NTPase_1 PF03266.15 EXF77609.1 - 0.06 13.2 0.3 4.4 7.2 0.2 2.6 2 0 0 2 2 2 0 NTPase DAP3 PF10236.9 EXF77609.1 - 0.073 12.2 0.1 5.9 6.0 0.0 2.6 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 DUF815 PF05673.13 EXF77609.1 - 0.08 12.1 0.1 3.6 6.7 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Ras PF00071.22 EXF77609.1 - 0.11 12.1 0.0 12 5.5 0.0 2.6 2 0 0 2 2 2 0 Ras family TsaE PF02367.17 EXF77609.1 - 0.11 12.5 0.3 25 4.9 0.0 3.1 2 1 1 3 3 3 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE FeoB_N PF02421.18 EXF77609.1 - 0.13 11.8 0.0 12 5.4 0.0 2.7 2 0 0 2 2 2 0 Ferrous iron transport protein B Rad17 PF03215.15 EXF77609.1 - 0.13 12.1 0.0 23 4.8 0.0 2.5 2 0 0 2 2 2 0 Rad17 P-loop domain DUF87 PF01935.17 EXF77609.1 - 0.15 12.1 0.6 29 4.7 0.0 2.9 3 0 0 3 3 2 0 Helicase HerA, central domain DUF3584 PF12128.8 EXF77609.1 - 0.16 9.4 0.6 0.42 8.1 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) Adeno_IVa2 PF02456.15 EXF77609.1 - 0.19 10.5 0.1 8.4 5.1 0.0 2.3 2 0 0 2 2 2 0 Adenovirus IVa2 protein MARVEL PF01284.23 EXF77610.1 - 0.02 14.9 0.6 5.8 6.9 0.0 2.2 2 0 0 2 2 2 0 Membrane-associating domain Claudin_3 PF06653.11 EXF77610.1 - 0.032 14.2 0.5 0.058 13.3 0.5 1.3 1 0 0 1 1 1 0 Tight junction protein, Claudin-like LapA_dom PF06305.11 EXF77611.1 - 2.9 7.8 3.9 1 9.3 0.0 2.1 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain GFO_IDH_MocA PF01408.22 EXF77613.1 - 5.9e-24 85.2 0.0 1e-23 84.4 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 EXF77613.1 - 4.7e-14 52.4 0.0 9.6e-14 51.4 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain DUF4734 PF15881.5 EXF77613.1 - 0.049 13.8 0.0 0.12 12.5 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4734) NAD_binding_3 PF03447.16 EXF77613.1 - 0.17 12.5 0.0 0.35 11.5 0.0 1.4 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain Tannase PF07519.11 EXF77616.1 - 8.2e-87 292.1 0.1 1e-86 291.7 0.1 1.0 1 0 0 1 1 1 1 Tannase and feruloyl esterase Peptidase_S9 PF00326.21 EXF77616.1 - 0.0094 15.4 0.1 2.1 7.8 0.1 2.1 2 0 0 2 2 2 2 Prolyl oligopeptidase family FMO-like PF00743.19 EXF77617.1 - 3.4e-60 204.0 0.0 5.2e-60 203.4 0.0 1.3 1 1 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EXF77617.1 - 4.6e-22 78.7 0.0 1.2e-18 67.4 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EXF77617.1 - 8.5e-14 51.5 0.0 9.3e-10 38.2 0.0 2.3 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EXF77617.1 - 2.3e-07 30.3 0.0 3.5e-06 26.4 0.0 2.1 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 EXF77617.1 - 7e-06 26.1 0.0 1.1 9.2 0.0 3.5 3 0 0 3 3 3 2 FAD-NAD(P)-binding IlvN PF07991.12 EXF77617.1 - 0.0027 17.3 0.0 0.37 10.3 0.0 2.4 2 0 0 2 2 2 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain NAD_binding_8 PF13450.6 EXF77617.1 - 0.0032 17.7 0.0 0.014 15.6 0.0 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain NAD_binding_2 PF03446.15 EXF77617.1 - 0.0033 17.6 0.2 0.064 13.4 0.0 2.4 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase Pyr_redox PF00070.27 EXF77617.1 - 0.0051 17.3 0.8 2.3 8.8 0.0 2.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EXF77617.1 - 0.0069 16.0 0.7 4.5 6.8 0.1 3.3 3 1 1 4 4 4 1 FAD dependent oxidoreductase 2-Hacid_dh_C PF02826.19 EXF77617.1 - 0.014 14.7 0.1 2.3 7.5 0.0 2.5 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 EXF77617.1 - 0.016 15.2 0.0 2 8.5 0.0 2.6 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase ThiF PF00899.21 EXF77617.1 - 0.022 14.1 0.4 0.75 9.1 0.1 2.3 2 0 0 2 2 2 0 ThiF family UDPG_MGDP_dh_N PF03721.14 EXF77617.1 - 0.025 14.1 0.3 0.16 11.5 0.0 2.1 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_binding_7 PF13241.6 EXF77617.1 - 0.029 14.8 0.1 3.6 8.1 0.0 2.5 2 1 0 2 2 2 0 Putative NAD(P)-binding HET PF06985.11 EXF77618.1 - 8.1e-33 113.8 0.4 1.3e-32 113.1 0.4 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) HET PF06985.11 EXF77619.1 - 4.9e-34 117.8 0.3 9.1e-34 116.9 0.3 1.5 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Abhydrolase_4 PF08386.10 EXF77621.1 - 2.3e-17 63.0 0.0 4.8e-17 62.0 0.0 1.5 1 0 0 1 1 1 1 TAP-like protein Abhydrolase_1 PF00561.20 EXF77621.1 - 1.6e-15 57.4 0.1 5.9e-06 26.1 0.0 3.1 3 0 0 3 3 3 3 alpha/beta hydrolase fold RE_CfrBI PF09516.10 EXF77621.1 - 0.27 10.6 0.1 0.44 9.9 0.1 1.2 1 0 0 1 1 1 0 CfrBI restriction endonuclease Git3 PF11710.8 EXF77622.1 - 5e-10 39.5 0.7 8.5e-10 38.7 0.7 1.4 1 1 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 GPR_Gpa2_C PF11970.8 EXF77622.1 - 0.00026 21.0 0.0 0.00065 19.7 0.0 1.6 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 C-term 7tm_1 PF00001.21 EXF77622.1 - 0.002 17.5 0.3 0.0025 17.2 0.3 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Sugar_tr PF00083.24 EXF77623.1 - 1.2e-57 195.8 24.4 1e-32 113.7 0.2 3.0 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 EXF77623.1 - 1.3e-17 63.8 33.8 3.4e-14 52.5 4.7 3.0 1 1 1 2 2 2 2 Major Facilitator Superfamily BNR_4 PF15892.5 EXF77624.1 - 4e-45 154.3 0.6 4.8e-45 154.0 0.6 1.0 1 0 0 1 1 1 1 BNR repeat-containing family member DUF5124 PF17160.4 EXF77624.1 - 0.015 16.1 0.1 0.029 15.1 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5124) Orf78 PF06024.12 EXF77625.1 - 0.016 15.5 0.0 0.026 14.8 0.0 1.3 1 0 0 1 1 1 0 Orf78 (ac78) EphA2_TM PF14575.6 EXF77625.1 - 0.075 13.9 0.1 0.11 13.4 0.1 1.4 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain TMEM154 PF15102.6 EXF77625.1 - 0.078 12.9 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 TMEM154 protein family NdhL PF10716.9 EXF77625.1 - 0.17 11.9 0.0 0.33 10.9 0.0 1.4 1 0 0 1 1 1 0 NADH dehydrogenase transmembrane subunit p450 PF00067.22 EXF77626.1 - 2.6e-56 191.3 0.0 3.4e-56 190.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 ADH_zinc_N PF00107.26 EXF77627.1 - 2.4e-13 50.2 0.0 5.2e-13 49.1 0.0 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EXF77627.1 - 1.3e-08 34.7 0.0 2.9e-08 33.6 0.0 1.6 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 EXF77627.1 - 7.9e-08 33.4 0.0 1.4e-07 32.6 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 EXF77628.1 - 2.5e-08 34.0 0.5 4.5e-08 33.1 0.1 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EXF77628.1 - 1.1e-07 31.7 0.2 2.5e-07 30.5 0.2 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain mTERF PF02536.14 EXF77628.1 - 0.13 11.2 0.0 0.19 10.6 0.0 1.2 1 0 0 1 1 1 0 mTERF Acyltransferase PF01553.21 EXF77629.1 - 7.1e-28 96.9 0.0 1e-27 96.4 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase Acyltransf_C PF16076.5 EXF77629.1 - 2.2e-12 46.9 0.1 4.1e-12 46.0 0.1 1.4 1 0 0 1 1 1 1 Acyltransferase C-terminus Pkinase PF00069.25 EXF77631.1 - 1.4e-12 47.6 0.0 2.3e-12 46.9 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF77631.1 - 0.0028 17.0 0.0 0.0038 16.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EXF77631.1 - 0.069 13.1 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 EXF77631.1 - 0.1 11.9 0.0 0.17 11.2 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family TPR_11 PF13414.6 EXF77631.1 - 0.18 11.5 0.1 0.45 10.2 0.1 1.7 1 0 0 1 1 1 0 TPR repeat Sugar_tr PF00083.24 EXF77632.1 - 3.4e-75 253.6 26.8 3.9e-75 253.4 26.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF77632.1 - 7.9e-15 54.6 44.2 1.7e-10 40.4 20.3 2.4 1 1 2 3 3 3 2 Major Facilitator Superfamily DUF3792 PF12670.7 EXF77632.1 - 8 6.7 21.6 6.2 7.0 2.1 4.0 3 1 1 4 4 4 0 Protein of unknown function (DUF3792) 5_nucleotid_C PF02872.18 EXF77633.1 - 3.3e-34 118.4 0.2 7e-34 117.3 0.2 1.5 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Metallophos PF00149.28 EXF77633.1 - 6.6e-10 39.8 0.9 4.1e-09 37.2 0.4 2.1 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase EthD PF07110.11 EXF77637.1 - 0.0078 17.3 0.0 0.016 16.4 0.0 1.5 1 0 0 1 1 1 1 EthD domain Fungal_trans PF04082.18 EXF77638.1 - 8.1e-08 31.6 0.1 1.5e-07 30.7 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain FPN1 PF06963.12 EXF77639.1 - 1.3e-115 386.5 10.3 1.5e-115 386.2 10.3 1.0 1 0 0 1 1 1 1 Ferroportin1 (FPN1) PalH PF08733.10 EXF77639.1 - 0.2 10.6 5.6 1.6 7.6 0.2 3.0 3 0 0 3 3 3 0 PalH/RIM21 PQ-loop PF04193.14 EXF77640.1 - 4.2e-36 122.5 3.2 8.3e-19 67.1 0.1 2.6 2 0 0 2 2 2 2 PQ loop repeat Exo_endo_phos PF03372.23 EXF77641.1 - 1.9e-09 37.4 0.0 6.9e-09 35.6 0.0 1.8 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Lactonase PF10282.9 EXF77643.1 - 2.5e-82 276.9 0.2 3.1e-82 276.6 0.2 1.0 1 0 0 1 1 1 1 Lactonase, 7-bladed beta-propeller FAD_binding_4 PF01565.23 EXF77644.1 - 3.6e-20 72.1 0.4 1.2e-19 70.4 0.5 1.8 2 0 0 2 2 2 1 FAD binding domain BBE PF08031.12 EXF77644.1 - 2.3e-08 34.0 1.2 5.2e-08 32.9 1.2 1.6 1 0 0 1 1 1 1 Berberine and berberine like PS-DH PF14765.6 EXF77645.1 - 2e-58 198.0 0.0 4.6e-58 196.8 0.0 1.6 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 EXF77645.1 - 9e-58 196.3 0.2 1.3e-57 195.7 0.2 1.3 1 0 0 1 1 1 1 Acyl transferase domain ketoacyl-synt PF00109.26 EXF77645.1 - 2e-57 194.7 0.2 9.9e-57 192.4 0.0 2.2 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.10 EXF77645.1 - 3e-55 186.9 0.1 8.9e-55 185.4 0.1 1.8 1 0 0 1 1 1 1 KR domain NAD_kinase PF01513.21 EXF77645.1 - 2.6e-50 171.3 0.0 5.8e-50 170.1 0.0 1.5 1 0 0 1 1 1 1 ATP-NAD kinase Ketoacyl-synt_C PF02801.22 EXF77645.1 - 2.6e-29 101.6 0.3 2.6e-29 101.6 0.3 2.1 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain Methyltransf_12 PF08242.12 EXF77645.1 - 5.2e-19 68.8 0.0 1.2e-18 67.6 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain ADH_zinc_N_2 PF13602.6 EXF77645.1 - 3.3e-18 67.0 0.0 1e-16 62.2 0.0 2.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 EXF77645.1 - 4.7e-14 52.5 0.1 1.8e-13 50.6 0.1 2.0 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Methyltransf_23 PF13489.6 EXF77645.1 - 1.2e-10 41.5 0.0 2.6e-10 40.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain adh_short PF00106.25 EXF77645.1 - 2.1e-10 40.4 0.0 7.9e-10 38.5 0.0 1.9 2 0 0 2 2 2 1 short chain dehydrogenase Methyltransf_25 PF13649.6 EXF77645.1 - 3.4e-09 37.3 0.0 9.3e-09 35.9 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF77645.1 - 2.3e-08 34.0 0.0 5.3e-08 32.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF77645.1 - 7.2e-08 33.0 0.0 1.8e-07 31.7 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain ADH_N PF08240.12 EXF77645.1 - 1.5e-06 28.0 0.3 3.2e-06 27.0 0.3 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Thiolase_N PF00108.23 EXF77645.1 - 0.00012 21.6 0.1 0.00098 18.6 0.1 2.2 2 0 0 2 2 2 1 Thiolase, N-terminal domain KAsynt_C_assoc PF16197.5 EXF77645.1 - 0.0016 18.9 0.0 0.0045 17.4 0.0 1.8 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Ubie_methyltran PF01209.18 EXF77645.1 - 0.0019 17.6 0.0 0.0041 16.5 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family ACP_syn_III PF08545.10 EXF77645.1 - 0.024 14.5 0.5 0.06 13.2 0.5 1.7 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III SAT PF16073.5 EXF77645.1 - 0.054 13.2 0.0 10 5.8 0.0 2.4 2 0 0 2 2 2 0 Starter unit:ACP transacylase in aflatoxin biosynthesis Methyltransf_28 PF02636.17 EXF77645.1 - 0.095 12.3 0.0 2.6 7.6 0.0 2.3 2 0 0 2 2 2 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_16 PF10294.9 EXF77645.1 - 0.18 11.5 0.0 0.77 9.5 0.0 1.9 1 1 0 1 1 1 0 Lysine methyltransferase DUF3328 PF11807.8 EXF77646.1 - 7.6e-18 65.1 5.1 3.9e-17 62.8 5.1 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF3328) Thioesterase PF00975.20 EXF77648.1 - 3.5e-11 43.6 0.0 5.8e-11 43.0 0.0 1.4 1 0 0 1 1 1 1 Thioesterase domain Abhydrolase_6 PF12697.7 EXF77648.1 - 4.7e-07 30.6 1.1 5.7e-07 30.4 1.1 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.13 EXF77648.1 - 0.00095 19.1 0.0 0.0014 18.5 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF2974 PF11187.8 EXF77648.1 - 0.0096 15.5 0.0 0.015 14.9 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2974) DUF2235 PF09994.9 EXF77648.1 - 0.042 13.2 0.0 0.053 12.9 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized alpha/beta hydrolase domain (DUF2235) Abhydrolase_2 PF02230.16 EXF77648.1 - 0.16 11.7 0.0 0.24 11.2 0.0 1.2 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase Lipase_3 PF01764.25 EXF77648.1 - 0.23 11.3 0.0 0.38 10.6 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) DUF3328 PF11807.8 EXF77649.1 - 1.5e-16 60.8 0.3 2.7e-16 60.0 0.3 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF3328) RXT2_N PF08595.11 EXF77650.1 - 0.22 11.6 0.1 0.38 10.8 0.1 1.4 1 0 0 1 1 1 0 RXT2-like, N-terminal DUF5055 PF16478.5 EXF77651.1 - 0.046 14.0 8.9 5.1 7.4 1.1 4.3 1 1 4 5 5 5 0 Domain of unknown function (DUF5055) DUF4119 PF13494.6 EXF77651.1 - 0.29 11.3 4.3 16 5.7 0.2 3.7 1 1 3 4 4 4 0 Domain of unknown function, B. Theta Gene description (DUF4119) RNase_J_C PF17770.1 EXF77651.1 - 2.7 9.1 5.8 23 6.1 0.1 4.5 2 2 3 5 5 5 0 Ribonuclease J C-terminal domain MFS_1 PF07690.16 EXF77654.1 - 2.4e-24 85.9 29.4 4.7e-18 65.2 10.2 3.0 1 1 2 3 3 3 3 Major Facilitator Superfamily MFS_4 PF06779.14 EXF77654.1 - 2.4e-06 27.1 11.5 1.2e-05 24.8 1.3 3.3 1 1 2 3 3 3 3 Uncharacterised MFS-type transporter YbfB DUF3040 PF11239.8 EXF77654.1 - 1.1 9.6 0.0 1.1 9.6 0.0 3.5 2 2 3 5 5 5 0 Protein of unknown function (DUF3040) Sugar_tr PF00083.24 EXF77654.1 - 1.3 7.8 16.3 0.011 14.6 5.9 2.4 2 1 1 3 3 3 0 Sugar (and other) transporter HTH_51 PF18558.1 EXF77655.1 - 8.8e-29 99.2 0.0 2.2e-28 98.0 0.0 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain Methyltransf_12 PF08242.12 EXF77655.1 - 1.4e-16 61.0 0.0 3.6e-16 59.7 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF77655.1 - 3.1e-12 47.0 0.0 5.9e-12 46.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EXF77655.1 - 1.7e-10 41.0 0.0 5.3e-10 39.4 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF77655.1 - 1.9e-10 41.2 0.0 3.5e-10 40.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF77655.1 - 2.6e-06 27.3 0.0 4.4e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EXF77655.1 - 1.8e-05 24.2 0.0 0.00026 20.4 0.0 2.3 2 1 0 2 2 2 1 ubiE/COQ5 methyltransferase family DUF938 PF06080.12 EXF77655.1 - 0.015 15.1 0.0 0.026 14.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF938) NPL4 PF05021.15 EXF77655.1 - 0.12 11.7 0.1 0.18 11.2 0.1 1.2 1 0 0 1 1 1 0 NPL4 family Methyltransf_33 PF10017.9 EXF77655.1 - 0.12 11.5 0.0 0.18 10.9 0.0 1.2 1 0 0 1 1 1 0 Histidine-specific methyltransferase, SAM-dependent NNMT_PNMT_TEMT PF01234.17 EXF77655.1 - 0.17 11.0 0.0 4.6 6.4 0.0 2.1 2 0 0 2 2 2 0 NNMT/PNMT/TEMT family ADH_zinc_N PF00107.26 EXF77656.1 - 9.5e-12 45.0 0.7 1.5e-11 44.4 0.1 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EXF77656.1 - 3.7e-08 33.2 0.1 4.6e-07 29.7 0.1 2.4 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_N_2 PF16884.5 EXF77656.1 - 0.0036 17.2 0.1 0.25 11.2 0.1 2.7 2 1 0 2 2 2 1 N-terminal domain of oxidoreductase PS-DH PF14765.6 EXF77657.1 - 5.6e-63 212.9 0.0 8.5e-63 212.4 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase ketoacyl-synt PF00109.26 EXF77657.1 - 2.5e-56 191.1 0.0 6.6e-56 189.7 0.0 1.8 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.10 EXF77657.1 - 6.9e-53 179.2 0.0 1.7e-52 178.0 0.0 1.7 1 0 0 1 1 1 1 KR domain Acyl_transf_1 PF00698.21 EXF77657.1 - 1.2e-51 176.2 0.0 2e-51 175.4 0.0 1.3 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EXF77657.1 - 7.5e-32 109.8 0.0 2.9e-31 107.9 0.0 2.1 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 EXF77657.1 - 1.5e-22 80.2 0.0 3e-22 79.2 0.0 1.6 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension adh_short PF00106.25 EXF77657.1 - 8.7e-09 35.1 0.0 2.6e-08 33.6 0.0 1.8 1 0 0 1 1 1 1 short chain dehydrogenase PP-binding PF00550.25 EXF77657.1 - 1e-06 29.0 0.1 2.8e-06 27.6 0.1 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site adh_short_C2 PF13561.6 EXF77657.1 - 1.1e-05 25.1 0.0 3.1e-05 23.6 0.0 1.7 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Thiolase_N PF00108.23 EXF77657.1 - 0.0034 16.8 0.7 0.0094 15.3 0.7 1.7 1 0 0 1 1 1 1 Thiolase, N-terminal domain Sacchrp_dh_NADP PF03435.18 EXF77657.1 - 0.051 13.8 0.0 0.27 11.5 0.0 2.2 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain NAD_binding_10 PF13460.6 EXF77657.1 - 0.08 12.8 0.1 1.4 8.8 0.0 2.6 2 0 0 2 2 2 0 NAD(P)H-binding ACP_syn_III PF08545.10 EXF77657.1 - 0.13 12.1 1.3 0.35 10.7 1.3 1.6 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III EamA PF00892.20 EXF77658.1 - 5.7e-14 52.5 35.3 1.5e-09 38.2 7.4 2.1 2 0 0 2 2 2 2 EamA-like transporter family Trp_oprn_chp PF09534.10 EXF77658.1 - 0.098 12.4 0.6 2.2 8.0 0.5 2.5 2 0 0 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) COX14 PF14880.6 EXF77658.1 - 1.6 8.7 0.0 1.6 8.7 0.0 2.7 4 0 0 4 4 4 0 Cytochrome oxidase c assembly p450 PF00067.22 EXF77659.1 - 2.9e-32 112.0 0.0 4.1e-32 111.5 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 Zn_clus PF00172.18 EXF77660.1 - 8e-10 38.7 6.4 2.1e-09 37.4 6.4 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EXF77660.1 - 0.0047 16.0 0.6 0.0075 15.3 0.1 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain Methyltransf_12 PF08242.12 EXF77661.1 - 1.7e-06 28.7 0.0 3.6e-06 27.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF77661.1 - 1.2e-05 25.9 0.0 4.7e-05 24.0 0.0 2.0 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF77661.1 - 6.6e-05 23.5 0.0 0.00029 21.4 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Peptidase_S41 PF03572.18 EXF77662.1 - 5.4e-09 35.8 0.0 1e-08 34.9 0.0 1.4 1 0 0 1 1 1 1 Peptidase family S41 Alpha-amylase PF00128.24 EXF77663.1 - 1.4e-23 84.0 5.8 5.8e-23 82.0 5.8 1.8 1 1 0 1 1 1 1 Alpha amylase, catalytic domain Glyco_hydro_70 PF02324.16 EXF77663.1 - 0.00022 19.6 0.3 0.098 10.8 0.0 3.0 3 0 0 3 3 3 3 Glycosyl hydrolase family 70 DUF1939 PF09154.10 EXF77663.1 - 0.08 13.1 0.0 0.19 11.9 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1939) AMP-binding PF00501.28 EXF77664.1 - 1.5e-137 458.7 0.0 8.5e-69 232.2 0.0 2.3 2 0 0 2 2 2 2 AMP-binding enzyme Condensation PF00668.20 EXF77664.1 - 5.4e-124 414.3 6.3 2.1e-48 165.1 0.1 5.4 5 1 0 5 5 5 4 Condensation domain PP-binding PF00550.25 EXF77664.1 - 2e-33 114.5 0.0 2.1e-11 44.0 0.0 4.1 3 0 0 3 3 3 3 Phosphopantetheine attachment site AMP-binding_C PF13193.6 EXF77664.1 - 0.05 14.6 0.0 5.8 8.0 0.0 2.9 2 0 0 2 2 2 0 AMP-binding enzyme C-terminal domain O-FucT PF10250.9 EXF77665.1 - 6.2e-11 42.6 0.1 3.3e-09 36.9 0.1 2.7 1 1 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase Hjc PF01870.18 EXF77665.1 - 0.035 14.1 0.0 0.086 12.8 0.0 1.6 1 1 0 1 1 1 0 Archaeal holliday junction resolvase (hjc) DUF3328 PF11807.8 EXF77666.1 - 0.03 14.1 1.9 0.91 9.3 0.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3328) CDH-cyt PF16010.5 EXF77667.1 - 2.1e-52 177.4 0.2 4.9e-52 176.3 0.2 1.7 1 0 0 1 1 1 1 Cytochrome domain of cellobiose dehydrogenase GMC_oxred_N PF00732.19 EXF77667.1 - 2.4e-28 99.4 0.0 6.5e-28 98.0 0.0 1.8 1 1 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EXF77667.1 - 2.9e-19 70.0 0.1 2.9e-19 70.0 0.1 1.9 2 0 0 2 2 2 1 GMC oxidoreductase FAD_binding_2 PF00890.24 EXF77667.1 - 3e-09 36.5 0.1 1e-06 28.1 0.2 2.1 2 0 0 2 2 2 2 FAD binding domain HI0933_like PF03486.14 EXF77667.1 - 2.8e-07 29.6 1.4 9.2e-07 27.9 0.2 2.0 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox_2 PF07992.14 EXF77667.1 - 6.9e-07 28.8 0.1 5.1e-06 25.9 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EXF77667.1 - 8.1e-07 28.9 0.3 0.0004 20.1 0.2 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase FAD_oxidored PF12831.7 EXF77667.1 - 1.3e-06 28.1 0.6 2.3e-06 27.2 0.6 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 EXF77667.1 - 3e-06 26.7 0.4 5.3e-06 25.9 0.4 1.4 1 0 0 1 1 1 1 FAD binding domain Lycopene_cycl PF05834.12 EXF77667.1 - 7.4e-05 22.0 0.7 0.00017 20.8 0.7 1.6 1 0 0 1 1 1 1 Lycopene cyclase protein GIDA PF01134.22 EXF77667.1 - 0.00014 21.0 0.0 0.00031 19.9 0.0 1.5 1 0 0 1 1 1 1 Glucose inhibited division protein A NAD_binding_8 PF13450.6 EXF77667.1 - 0.00021 21.5 0.1 0.00021 21.5 0.1 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 EXF77667.1 - 0.00031 20.1 0.7 0.0023 17.2 1.1 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EXF77667.1 - 0.0012 18.1 0.2 0.0022 17.3 0.2 1.3 1 0 0 1 1 1 1 Thi4 family Pyr_redox PF00070.27 EXF77667.1 - 0.0015 19.1 0.1 0.005 17.4 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EXF77667.1 - 0.014 14.3 0.2 0.024 13.5 0.2 1.3 1 0 0 1 1 1 0 Tryptophan halogenase GMC_oxred_N PF00732.19 EXF77668.1 - 5.5e-53 180.3 0.1 7.3e-53 179.9 0.1 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EXF77668.1 - 2.4e-37 128.7 0.0 5.1e-37 127.6 0.0 1.6 1 0 0 1 1 1 1 GMC oxidoreductase Lycopene_cycl PF05834.12 EXF77668.1 - 7.7e-05 21.9 0.0 0.00014 21.1 0.0 1.4 1 0 0 1 1 1 1 Lycopene cyclase protein DAO PF01266.24 EXF77668.1 - 0.0019 17.9 0.4 0.012 15.2 0.2 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EXF77668.1 - 0.0035 16.6 0.1 0.023 13.9 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EXF77668.1 - 0.018 15.2 0.6 0.054 13.7 0.6 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 EXF77668.1 - 0.029 13.6 0.0 1.1 8.5 0.0 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EXF77668.1 - 0.13 11.4 0.2 0.2 10.7 0.2 1.3 1 0 0 1 1 1 0 FAD binding domain TIC20 PF16166.5 EXF77669.1 - 1.5 8.6 6.0 0.49 10.2 2.5 1.9 2 0 0 2 2 2 0 Chloroplast import apparatus Tic20-like DUF5381 PF17353.2 EXF77669.1 - 1.7 8.3 7.2 0.095 12.4 1.5 1.7 2 0 0 2 2 2 0 Family of unknown function (DUF5381) Fungal_trans_2 PF11951.8 EXF77670.1 - 1.1e-21 77.1 1.2 1.6e-21 76.6 1.2 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF77670.1 - 3e-05 24.1 8.1 5.7e-05 23.2 8.1 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EXF77671.1 - 1.4e-05 24.3 0.0 2.2e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF77671.1 - 4.5e-05 23.5 8.9 9.1e-05 22.5 8.9 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Citrate_synt PF00285.21 EXF77671.1 - 0.023 13.8 1.1 0.029 13.4 0.3 1.6 2 0 0 2 2 2 0 Citrate synthase, C-terminal domain CAP PF00188.26 EXF77672.1 - 8.6e-18 65.4 0.2 1.3e-17 64.8 0.2 1.3 1 0 0 1 1 1 1 Cysteine-rich secretory protein family PhaG_MnhG_YufB PF03334.14 EXF77672.1 - 0.0034 17.6 1.1 0.0066 16.7 1.1 1.4 1 0 0 1 1 1 1 Na+/H+ antiporter subunit DUF3446 PF11928.8 EXF77672.1 - 0.75 10.1 8.3 2 8.7 8.3 1.8 1 1 0 1 1 1 0 Early growth response N-terminal domain FtsH_ext PF06480.15 EXF77672.1 - 1.1 9.6 3.9 14 6.1 0.3 2.7 2 1 0 2 2 2 0 FtsH Extracellular Tubulin PF00091.25 EXF77673.1 - 6.5e-71 238.6 0.0 2e-70 237.0 0.0 1.7 2 0 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EXF77673.1 - 1.9e-38 131.4 0.1 3e-38 130.8 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 EXF77673.1 - 4.2e-07 30.3 0.0 9.2e-07 29.2 0.0 1.6 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.6 EXF77673.1 - 0.0049 16.6 0.0 0.0096 15.6 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain Tubulin_2 PF13809.6 EXF77673.1 - 0.025 13.8 0.0 0.045 12.9 0.0 1.4 1 0 0 1 1 1 0 Tubulin like HET PF06985.11 EXF77674.1 - 2.1e-24 86.5 0.3 4.3e-24 85.5 0.3 1.6 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Promethin PF16015.5 EXF77675.1 - 1.3e-33 115.1 13.7 1.6e-33 114.8 13.7 1.1 1 0 0 1 1 1 1 Promethin Wzy_C PF04932.15 EXF77675.1 - 0.039 13.6 4.2 0.062 12.9 3.8 1.7 2 0 0 2 2 2 0 O-Antigen ligase DUF2207 PF09972.9 EXF77675.1 - 0.68 8.6 3.0 0.9 8.2 3.0 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Fungal_trans_2 PF11951.8 EXF77676.1 - 3.6e-10 39.2 0.3 3.6e-10 39.2 0.3 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF77676.1 - 1.1e-07 31.9 12.4 1.8e-07 31.1 12.4 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Ysc84 PF04366.12 EXF77677.1 - 9.8e-44 148.2 0.1 1.6e-43 147.5 0.1 1.3 1 0 0 1 1 1 1 Las17-binding protein actin regulator MAP65_ASE1 PF03999.12 EXF77677.1 - 1.9 7.1 7.2 2.5 6.7 7.2 1.1 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) AAA PF00004.29 EXF77678.1 - 5.8e-41 140.0 0.0 1e-40 139.2 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 EXF77678.1 - 1.1e-11 44.5 0.2 2.4e-11 43.4 0.2 1.7 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 EXF77678.1 - 5.5e-11 42.1 0.4 1e-10 41.2 0.4 1.4 1 0 0 1 1 1 1 AAA+ lid domain AAA_2 PF07724.14 EXF77678.1 - 4.7e-06 26.8 0.0 9.5e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 EXF77678.1 - 8.7e-06 26.1 0.1 0.0065 16.7 0.1 2.5 1 1 0 1 1 1 1 AAA domain DUF815 PF05673.13 EXF77678.1 - 1.5e-05 24.3 0.0 2.6e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_5 PF07728.14 EXF77678.1 - 0.00019 21.5 0.1 0.00066 19.7 0.1 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EXF77678.1 - 0.0004 20.8 0.1 0.0073 16.7 0.1 2.2 1 1 1 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 EXF77678.1 - 0.00048 19.9 0.0 0.00093 19.0 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain Prot_ATP_OB_N PF17758.1 EXF77678.1 - 0.00099 18.7 0.3 0.0069 16.0 0.0 2.4 2 0 0 2 2 2 1 Proteasomal ATPase OB N-terminal domain AAA_18 PF13238.6 EXF77678.1 - 0.0025 18.3 0.0 0.0053 17.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.6 EXF77678.1 - 0.0036 17.6 0.2 0.0094 16.2 0.0 1.8 2 0 0 2 2 1 1 AAA domain AAA_33 PF13671.6 EXF77678.1 - 0.0086 16.2 0.1 0.029 14.6 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_3 PF07726.11 EXF77678.1 - 0.018 14.9 0.0 0.034 14.0 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.17 EXF77678.1 - 0.018 14.8 0.0 0.038 13.7 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein PhoH PF02562.16 EXF77678.1 - 0.019 14.5 1.5 0.51 9.8 0.1 2.2 2 0 0 2 2 2 0 PhoH-like protein TIP49 PF06068.13 EXF77678.1 - 0.024 13.9 0.0 0.055 12.7 0.0 1.5 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_14 PF13173.6 EXF77678.1 - 0.03 14.4 0.0 0.058 13.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EXF77678.1 - 0.055 13.9 0.0 0.11 12.9 0.0 1.5 1 0 0 1 1 1 0 RNA helicase Mg_chelatase PF01078.21 EXF77678.1 - 0.061 12.7 0.1 0.12 11.8 0.1 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI NACHT PF05729.12 EXF77678.1 - 0.068 13.1 0.1 0.62 10.0 0.1 2.3 1 1 1 2 2 2 0 NACHT domain ATPase PF06745.13 EXF77678.1 - 0.079 12.3 0.0 0.49 9.7 0.0 2.0 2 0 0 2 2 2 0 KaiC Zeta_toxin PF06414.12 EXF77678.1 - 0.095 12.0 0.1 0.19 11.0 0.1 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_25 PF13481.6 EXF77678.1 - 0.099 12.2 1.1 0.58 9.7 0.4 2.3 1 1 0 2 2 2 0 AAA domain DUF2075 PF09848.9 EXF77678.1 - 0.19 10.9 0.0 0.27 10.4 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_24 PF13479.6 EXF77678.1 - 0.24 11.1 1.7 0.33 10.6 0.3 2.0 2 1 0 2 2 2 0 AAA domain UQ_con PF00179.26 EXF77679.1 - 2.2e-40 137.6 0.0 3e-40 137.1 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UBA_3 PF09288.10 EXF77679.1 - 9.2e-06 25.4 0.1 1.9e-05 24.4 0.1 1.5 1 0 0 1 1 1 1 Fungal ubiquitin-associated domain Prok-E2_B PF14461.6 EXF77679.1 - 0.0049 16.6 0.0 0.0092 15.7 0.0 1.4 1 0 0 1 1 1 1 Prokaryotic E2 family B DUF1421 PF07223.11 EXF77679.1 - 0.081 12.8 0.1 0.15 11.9 0.1 1.4 1 0 0 1 1 1 0 UBA-like domain (DUF1421) CoA_binding PF02629.19 EXF77680.1 - 1.4e-24 86.6 2.2 7.9e-23 81.0 0.2 3.0 3 0 0 3 3 3 1 CoA binding domain Ligase_CoA PF00549.19 EXF77680.1 - 7.8e-23 81.0 0.2 1.4e-22 80.2 0.2 1.4 1 0 0 1 1 1 1 CoA-ligase Succ_CoA_lig PF13607.6 EXF77680.1 - 1.3e-09 38.0 0.0 2.1e-09 37.3 0.0 1.4 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.6 EXF77680.1 - 3.6e-05 24.2 0.0 0.00016 22.2 0.0 2.1 2 0 0 2 2 2 1 CoA binding domain Pept_tRNA_hydro PF01195.19 EXF77682.1 - 9.5e-26 90.8 0.0 1.1e-25 90.5 0.0 1.1 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase BAR PF03114.18 EXF77683.1 - 2.3e-67 227.1 5.1 3.3e-67 226.6 5.1 1.2 1 0 0 1 1 1 1 BAR domain CP12 PF02672.15 EXF77683.1 - 0.0042 17.8 2.3 0.0085 16.8 0.0 2.6 3 1 0 3 3 3 1 CP12 domain FliD_N PF02465.18 EXF77683.1 - 8 7.2 7.4 5.8 7.7 2.4 2.6 2 1 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus DCP1 PF06058.13 EXF77684.1 - 8.8e-32 109.5 0.0 1.2e-31 109.0 0.0 1.1 1 0 0 1 1 1 1 Dcp1-like decapping family Exo_endo_phos PF03372.23 EXF77685.1 - 2.9e-07 30.3 0.0 5.7e-07 29.3 0.0 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF1835 PF08874.10 EXF77685.1 - 0.19 12.0 0.2 0.42 10.8 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1835) RhoGAP PF00620.27 EXF77685.1 - 0.19 11.5 0.0 0.44 10.4 0.0 1.5 1 0 0 1 1 1 0 RhoGAP domain Methyltransf_23 PF13489.6 EXF77686.1 - 2.7e-19 69.6 0.0 3.6e-19 69.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF77686.1 - 7.7e-09 36.2 0.0 4e-08 33.8 0.0 2.2 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF77686.1 - 6.6e-08 32.5 0.0 7.2e-07 29.1 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF77686.1 - 8.9e-07 29.5 0.0 4.1e-06 27.4 0.0 2.0 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF77686.1 - 1.5e-06 28.8 0.0 1.2e-05 25.9 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EXF77686.1 - 0.0014 18.2 0.0 0.0022 17.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 EXF77686.1 - 0.11 11.9 0.0 0.16 11.3 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_2 PF00891.18 EXF77686.1 - 0.12 11.6 0.0 0.75 9.0 0.0 2.0 2 0 0 2 2 2 0 O-methyltransferase domain Methyltransf_4 PF02390.17 EXF77686.1 - 0.31 10.5 0.7 0.64 9.5 0.0 1.8 2 0 0 2 2 2 0 Putative methyltransferase F-box-like PF12937.7 EXF77687.1 - 1.2e-05 25.1 0.0 4.7e-05 23.2 0.0 2.1 1 1 0 1 1 1 1 F-box-like F-box-like PF12937.7 EXF77688.1 - 2e-06 27.6 0.1 8.9e-06 25.5 0.1 2.2 1 0 0 1 1 1 1 F-box-like CrtC PF07143.11 EXF77689.1 - 7.4e-05 23.5 0.6 0.00082 20.1 0.6 2.2 1 1 0 1 1 1 1 CrtC N-terminal lipocalin domain Hydrolase_4 PF12146.8 EXF77690.1 - 4e-17 62.3 0.0 1e-12 47.9 0.0 2.1 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EXF77690.1 - 1.7e-11 44.3 0.1 1.2e-07 31.6 0.1 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold AXE1 PF05448.12 EXF77690.1 - 3.6e-05 22.6 0.0 0.013 14.2 0.0 3.0 2 1 1 3 3 3 1 Acetyl xylan esterase (AXE1) Abhydrolase_6 PF12697.7 EXF77690.1 - 0.00014 22.6 0.1 0.0003 21.4 0.0 1.6 2 0 0 2 2 2 1 Alpha/beta hydrolase family DUF818 PF05677.12 EXF77690.1 - 0.0011 18.0 0.0 0.0016 17.5 0.0 1.1 1 0 0 1 1 1 1 Chlamydia CHLPS protein (DUF818) FSH1 PF03959.13 EXF77690.1 - 0.0013 18.5 0.0 0.0039 16.9 0.0 1.7 2 0 0 2 2 2 1 Serine hydrolase (FSH1) Peptidase_S9 PF00326.21 EXF77690.1 - 0.0022 17.5 0.0 0.024 14.1 0.0 2.1 1 1 0 1 1 1 1 Prolyl oligopeptidase family DLH PF01738.18 EXF77690.1 - 0.004 16.7 0.0 0.061 12.9 0.0 2.2 1 1 0 1 1 1 1 Dienelactone hydrolase family BAAT_C PF08840.11 EXF77690.1 - 0.048 13.6 0.0 1 9.2 0.0 2.3 2 0 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal Peptidase_S15 PF02129.18 EXF77690.1 - 0.066 12.8 0.0 7.8 6.0 0.0 2.2 2 0 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_3 PF07859.13 EXF77690.1 - 0.076 12.9 0.0 0.14 11.9 0.0 1.5 1 0 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 EXF77690.1 - 0.15 11.9 0.0 6.4 6.5 0.0 2.3 1 1 0 1 1 1 0 Phospholipase/Carboxylesterase Pex2_Pex12 PF04757.14 EXF77692.1 - 1.5e-39 135.9 1.4 1.9e-39 135.6 1.4 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_2 PF13923.6 EXF77692.1 - 1e-11 44.5 8.8 1.6e-11 43.9 8.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EXF77692.1 - 4.2e-11 43.0 9.2 6.3e-11 42.4 9.2 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 EXF77692.1 - 3.6e-10 39.5 6.2 5.4e-10 39.0 6.2 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EXF77692.1 - 5.6e-10 38.9 6.9 8.4e-10 38.4 6.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EXF77692.1 - 2.4e-07 31.0 5.3 4.1e-07 30.2 5.3 1.3 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 EXF77692.1 - 2.7e-07 30.5 7.4 5.3e-07 29.6 7.4 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 EXF77692.1 - 6.3e-07 29.2 5.9 1e-06 28.6 5.9 1.3 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EXF77692.1 - 1.9e-06 27.6 7.0 3.1e-06 26.9 7.0 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 EXF77692.1 - 3.4e-06 27.1 8.0 5.6e-06 26.4 8.0 1.3 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_10 PF16685.5 EXF77692.1 - 0.00021 21.4 5.1 0.00035 20.6 5.1 1.3 1 0 0 1 1 1 1 zinc RING finger of MSL2 zf-RING_6 PF14835.6 EXF77692.1 - 0.001 18.9 2.5 0.002 18.0 2.5 1.3 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-Nse PF11789.8 EXF77692.1 - 0.0097 15.7 1.4 0.018 14.8 1.4 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_4 PF14570.6 EXF77692.1 - 0.04 13.7 6.1 0.086 12.7 6.1 1.5 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-ANAPC11 PF12861.7 EXF77692.1 - 0.1 12.6 2.5 0.18 11.9 2.5 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.5 EXF77692.1 - 0.38 10.5 3.4 0.78 9.5 3.4 1.6 1 0 0 1 1 1 0 RING-like zinc finger CN_hydrolase PF00795.22 EXF77693.1 - 3.2e-42 144.7 0.0 4.6e-42 144.2 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase NAD_synthase PF02540.17 EXF77693.1 - 2.2e-22 79.3 0.0 1.1e-21 77.1 0.0 2.0 1 1 0 1 1 1 1 NAD synthase Dioxygenase_C PF00775.21 EXF77694.1 - 3.3e-07 29.9 0.0 5.5e-07 29.2 0.0 1.3 1 0 0 1 1 1 1 Dioxygenase WSC PF01822.19 EXF77695.1 - 8.1e-85 279.1 84.9 4.9e-17 61.9 11.9 5.6 5 0 0 5 5 5 5 WSC domain Glyoxal_oxid_N PF07250.11 EXF77695.1 - 5e-25 88.1 0.4 1.1e-24 87.0 0.0 1.8 2 0 0 2 2 2 1 Glyoxal oxidase N-terminus DUF1929 PF09118.11 EXF77695.1 - 3.2e-22 78.6 0.1 8.3e-22 77.3 0.1 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1929) Kelch_2 PF07646.15 EXF77695.1 - 0.011 15.7 0.0 6.3 6.9 0.3 4.0 2 1 1 3 3 3 0 Kelch motif NACHT PF05729.12 EXF77696.1 - 2.3e-10 40.6 0.1 0.00014 21.8 0.0 3.0 2 0 0 2 2 2 2 NACHT domain ABC_tran PF00005.27 EXF77696.1 - 3.3e-05 24.4 0.0 0.0028 18.2 0.0 2.7 2 1 0 2 2 2 1 ABC transporter AAA_16 PF13191.6 EXF77696.1 - 7.7e-05 23.1 0.0 0.0045 17.4 0.0 3.5 3 1 0 3 3 3 1 AAA ATPase domain Ank_4 PF13637.6 EXF77696.1 - 0.00061 20.3 0.0 0.19 12.3 0.0 3.2 3 0 0 3 3 2 1 Ankyrin repeats (many copies) AAA_22 PF13401.6 EXF77696.1 - 0.0011 19.3 0.0 0.0055 17.0 0.0 2.2 1 1 0 1 1 1 1 AAA domain AAA_23 PF13476.6 EXF77696.1 - 0.003 18.1 0.3 0.024 15.1 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EXF77696.1 - 0.0053 16.5 0.0 0.013 15.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 EXF77696.1 - 0.01 15.5 0.2 0.027 14.2 0.2 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_18 PF13238.6 EXF77696.1 - 0.037 14.6 0.0 0.81 10.2 0.0 3.2 4 0 0 4 4 4 0 AAA domain DUF87 PF01935.17 EXF77696.1 - 0.038 14.1 0.4 0.85 9.7 0.1 2.5 2 0 0 2 2 2 0 Helicase HerA, central domain RsgA_GTPase PF03193.16 EXF77696.1 - 0.062 13.2 0.0 0.24 11.3 0.0 1.9 2 0 0 2 2 2 0 RsgA GTPase AAA_33 PF13671.6 EXF77696.1 - 0.072 13.3 0.1 0.93 9.7 0.0 3.0 3 0 0 3 3 3 0 AAA domain AAA PF00004.29 EXF77696.1 - 0.079 13.4 0.2 1.5 9.2 0.0 2.9 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 EXF77696.1 - 0.079 13.4 0.1 0.26 11.7 0.0 1.9 2 0 0 2 2 1 0 RNA helicase ATPase_2 PF01637.18 EXF77696.1 - 0.18 11.7 0.2 0.62 9.9 0.0 1.9 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea Lipase_GDSL PF00657.22 EXF77697.1 - 1.1e-10 41.8 1.1 2.3e-10 40.8 1.1 1.6 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.6 EXF77697.1 - 1.6e-10 41.7 0.7 3.1e-10 40.8 0.7 1.5 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family CE2_N PF17996.1 EXF77697.1 - 0.059 13.4 0.1 0.11 12.5 0.1 1.6 1 1 0 1 1 1 0 Carbohydrate esterase 2 N-terminal Not3 PF04065.15 EXF77698.1 - 0.017 14.5 0.7 0.028 13.9 0.3 1.5 1 1 1 2 2 2 0 Not1 N-terminal domain, CCR4-Not complex component ZapA PF05164.13 EXF77698.1 - 0.048 14.1 1.1 0.095 13.1 1.1 1.5 1 1 0 1 1 1 0 Cell division protein ZapA UreE_C PF05194.12 EXF77698.1 - 0.13 12.7 15.5 0.23 11.9 14.5 2.0 1 1 1 2 2 2 0 UreE urease accessory protein, C-terminal domain ABC_tran PF00005.27 EXF77699.1 - 1.2e-42 145.6 0.0 4.1e-20 72.7 0.0 2.7 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EXF77699.1 - 1.9e-35 122.9 28.3 2.1e-25 89.9 10.5 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.19 EXF77699.1 - 1.1e-11 44.6 0.0 0.048 13.1 0.0 4.2 3 1 1 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EXF77699.1 - 2.5e-09 37.4 0.8 0.17 11.6 0.0 4.1 3 1 1 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 EXF77699.1 - 5.3e-08 33.0 2.3 0.0015 18.5 0.7 2.6 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EXF77699.1 - 1.8e-05 24.8 0.3 0.091 12.9 0.1 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_22 PF13401.6 EXF77699.1 - 2.6e-05 24.5 0.6 0.075 13.3 0.0 2.9 2 1 0 2 2 2 2 AAA domain AAA_29 PF13555.6 EXF77699.1 - 4.1e-05 23.2 0.9 0.16 11.7 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain SbcCD_C PF13558.6 EXF77699.1 - 9e-05 22.6 0.2 0.3 11.3 0.0 2.9 2 0 0 2 2 2 2 Putative exonuclease SbcCD, C subunit AAA_15 PF13175.6 EXF77699.1 - 0.0007 19.4 0.2 0.42 10.3 0.2 2.1 2 0 0 2 2 2 2 AAA ATPase domain Dynamin_N PF00350.23 EXF77699.1 - 0.0012 18.9 0.9 0.048 13.7 0.0 2.3 2 0 0 2 2 2 1 Dynamin family AAA_16 PF13191.6 EXF77699.1 - 0.0022 18.4 0.3 2.8 8.3 0.1 2.8 2 0 0 2 2 2 2 AAA ATPase domain AAA_7 PF12775.7 EXF77699.1 - 0.0085 15.6 0.4 2.4 7.6 0.2 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region DUF815 PF05673.13 EXF77699.1 - 0.0091 15.2 1.6 0.3 10.2 0.3 2.6 2 1 1 3 3 3 1 Protein of unknown function (DUF815) NB-ARC PF00931.22 EXF77699.1 - 0.014 14.6 1.2 0.8 8.8 0.6 2.9 2 1 0 2 2 2 0 NB-ARC domain AAA_23 PF13476.6 EXF77699.1 - 0.024 15.1 0.2 10 6.5 0.1 2.2 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 EXF77699.1 - 0.033 14.6 0.0 0.52 10.7 0.0 2.9 3 0 0 3 3 2 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 EXF77699.1 - 0.044 13.7 0.2 8.7 6.2 0.0 2.6 2 0 0 2 2 2 0 NACHT domain Roc PF08477.13 EXF77699.1 - 0.073 13.3 0.2 18 5.6 0.0 2.5 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase ATPase_2 PF01637.18 EXF77699.1 - 0.23 11.3 0.3 10 6.0 0.1 2.3 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea Rad17 PF03215.15 EXF77699.1 - 0.29 11.0 1.1 2.5 8.0 0.3 2.3 2 0 0 2 2 2 0 Rad17 P-loop domain AAA_5 PF07728.14 EXF77699.1 - 0.82 9.7 2.9 20 5.2 0.1 3.0 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) cobW PF02492.19 EXF77699.1 - 0.87 9.1 3.4 17 4.9 0.1 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain TPR_14 PF13428.6 EXF77700.1 - 0.18 12.7 4.9 0.43 11.5 0.1 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat ThiF PF00899.21 EXF77701.1 - 1.5e-41 142.4 0.0 2.4e-41 141.7 0.0 1.2 1 0 0 1 1 1 1 ThiF family Sacchrp_dh_NADP PF03435.18 EXF77701.1 - 1e-06 29.0 0.1 2.5e-06 27.8 0.1 1.6 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain TrkA_N PF02254.18 EXF77701.1 - 0.0079 16.5 0.1 0.033 14.4 0.1 2.1 1 0 0 1 1 1 1 TrkA-N domain NAD_binding_7 PF13241.6 EXF77701.1 - 0.01 16.3 0.0 0.029 14.8 0.0 1.8 1 0 0 1 1 1 1 Putative NAD(P)-binding MAF_flag10 PF01973.18 EXF77701.1 - 0.02 14.6 0.0 0.088 12.5 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function DUF115 UDPG_MGDP_dh_N PF03721.14 EXF77701.1 - 0.027 14.1 0.2 0.049 13.2 0.2 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Ribosomal_S14 PF00253.21 EXF77703.1 - 8.9e-23 79.8 1.7 1.1e-21 76.3 0.6 2.1 2 0 0 2 2 2 2 Ribosomal protein S14p/S29e Isy1 PF06246.12 EXF77704.1 - 8.4e-91 304.1 0.5 9.5e-91 303.9 0.5 1.0 1 0 0 1 1 1 1 Isy1-like splicing family YebG PF07130.12 EXF77704.1 - 0.028 14.3 0.4 0.058 13.2 0.4 1.6 1 0 0 1 1 1 0 YebG protein EMC1_C PF07774.13 EXF77705.1 - 5.1e-77 258.3 0.0 8.1e-77 257.7 0.0 1.3 1 0 0 1 1 1 1 ER membrane protein complex subunit 1, C-terminal PQQ_2 PF13360.6 EXF77705.1 - 3.2e-20 72.8 6.7 5.2e-18 65.5 3.2 2.7 2 0 0 2 2 2 2 PQQ-like domain EST1_DNA_bind PF10373.9 EXF77706.1 - 9.3e-10 38.4 0.2 1.9e-09 37.4 0.2 1.5 1 0 0 1 1 1 1 Est1 DNA/RNA binding domain Apt1 PF10351.9 EXF77706.1 - 2.4 6.9 9.1 4 6.2 9.1 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain HNH_2 PF13391.6 EXF77707.1 - 0.13 12.4 0.0 0.44 10.7 0.0 1.8 2 0 0 2 2 2 0 HNH endonuclease 2-Hacid_dh_C PF02826.19 EXF77708.1 - 4.7e-45 153.1 0.0 7.6e-45 152.4 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EXF77708.1 - 7.3e-05 22.4 0.0 0.00089 18.9 0.0 2.0 1 1 1 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain AdoHcyase_NAD PF00670.21 EXF77708.1 - 0.002 18.2 0.0 0.024 14.7 0.0 2.1 2 0 0 2 2 2 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain NAD_binding_7 PF13241.6 EXF77708.1 - 0.027 14.9 0.0 0.096 13.1 0.0 1.9 2 0 0 2 2 2 0 Putative NAD(P)-binding XdhC_C PF13478.6 EXF77708.1 - 0.11 12.9 0.0 0.61 10.6 0.0 2.0 2 0 0 2 2 2 0 XdhC Rossmann domain Glyco_hydro_47 PF01532.20 EXF77709.1 - 1.8e-156 521.6 0.0 2.2e-156 521.4 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 SKG6 PF08693.10 EXF77710.1 - 9.8e-06 24.9 2.3 3e-05 23.3 2.3 1.8 1 0 0 1 1 1 1 Transmembrane alpha-helix domain DUF4381 PF14316.6 EXF77710.1 - 0.021 15.1 0.0 0.044 14.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) TraL PF07178.11 EXF77710.1 - 0.17 12.4 0.1 0.42 11.1 0.1 1.6 1 0 0 1 1 1 0 TraL protein APH PF01636.23 EXF77711.1 - 4.6e-23 82.4 0.1 7.1e-23 81.8 0.1 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EXF77711.1 - 0.0076 15.2 0.0 0.011 14.7 0.0 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Choline_kinase PF01633.20 EXF77711.1 - 0.032 13.8 0.0 0.054 13.1 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase PH PF00169.29 EXF77712.1 - 0.00014 22.4 0.0 0.00049 20.6 0.0 2.0 1 1 0 1 1 1 1 PH domain SAM_2 PF07647.17 EXF77712.1 - 0.0062 16.6 0.0 0.012 15.7 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) MelC1 PF06236.11 EXF77712.1 - 0.73 9.9 2.7 4.5 7.4 0.3 3.2 3 1 1 4 4 4 0 Tyrosinase co-factor MelC1 Fungal_trans_2 PF11951.8 EXF77713.1 - 4.4e-83 279.2 0.0 5.9e-83 278.8 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF77713.1 - 2.1e-08 34.1 5.9 4.2e-08 33.2 5.9 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FerI PF08151.12 EXF77713.1 - 0.033 14.3 0.0 0.082 13.0 0.0 1.6 1 0 0 1 1 1 0 FerI (NUC094) domain Epimerase PF01370.21 EXF77715.1 - 0.09 12.2 0.0 0.12 11.8 0.0 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family KR PF08659.10 EXF77715.1 - 0.16 11.9 0.0 0.28 11.1 0.0 1.3 1 0 0 1 1 1 0 KR domain NAD_binding_4 PF07993.12 EXF77715.1 - 0.17 11.0 0.0 16 4.5 0.0 2.2 2 0 0 2 2 2 0 Male sterility protein PHD PF00628.29 EXF77720.1 - 2.3e-07 30.6 9.7 4.5e-07 29.6 9.7 1.5 1 0 0 1 1 1 1 PHD-finger SET PF00856.28 EXF77720.1 - 6.4e-05 23.4 0.3 0.00027 21.4 0.0 2.2 2 1 0 2 2 2 1 SET domain Glycos_transf_4 PF00953.21 EXF77721.1 - 1.4e-28 99.9 8.5 1.4e-28 99.9 8.5 2.1 3 0 0 3 3 3 1 Glycosyl transferase family 4 MFS_1 PF07690.16 EXF77722.1 - 1.1e-45 156.2 39.2 1.1e-45 156.2 39.2 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF77722.1 - 2.5e-15 56.3 3.6 2.5e-15 56.3 3.6 2.0 2 1 0 2 2 2 1 Sugar (and other) transporter MFS_4 PF06779.14 EXF77722.1 - 2.2e-06 27.2 1.8 2.2e-06 27.2 1.8 1.8 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB TRI12 PF06609.13 EXF77722.1 - 1.8e-05 23.4 1.2 3e-05 22.7 1.2 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Transglut_core PF01841.19 EXF77723.1 - 3e-08 34.1 0.1 6.6e-08 33.0 0.1 1.6 1 0 0 1 1 1 1 Transglutaminase-like superfamily Gln_amidase PF15644.6 EXF77723.1 - 0.045 14.8 0.0 0.13 13.3 0.0 1.9 1 1 0 1 1 1 0 Papain fold toxin 1, glutamine deamidase F-box-like PF12937.7 EXF77724.1 - 4.7e-07 29.6 0.4 9.7e-07 28.6 0.4 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EXF77724.1 - 2.4e-06 27.3 0.1 6.7e-06 25.9 0.1 1.7 1 0 0 1 1 1 1 F-box domain Spc7 PF08317.11 EXF77724.1 - 0.0012 17.8 1.9 0.0012 17.8 1.9 2.0 2 0 0 2 2 2 1 Spc7 kinetochore protein PilJ PF13675.6 EXF77724.1 - 0.011 15.7 0.7 0.051 13.6 0.7 2.2 1 0 0 1 1 1 0 Type IV pili methyl-accepting chemotaxis transducer N-term F-box-like_2 PF13013.6 EXF77724.1 - 0.027 14.5 0.0 0.066 13.2 0.0 1.8 1 0 0 1 1 1 0 F-box-like domain UPF0242 PF06785.11 EXF77724.1 - 0.06 13.5 1.7 0.14 12.3 1.7 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus VPS28 PF03997.12 EXF77724.1 - 0.061 13.0 0.5 0.14 11.8 0.5 1.5 1 0 0 1 1 1 0 VPS28 protein VirE_N PF08800.10 EXF77724.1 - 0.2 11.8 0.2 2.5 8.2 0.0 2.7 3 0 0 3 3 3 0 VirE N-terminal domain Fib_alpha PF08702.10 EXF77724.1 - 0.33 11.1 1.0 1 9.6 0.4 2.1 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family DegS PF05384.11 EXF77724.1 - 1.9 8.0 6.6 0.94 9.0 2.5 2.3 2 0 0 2 2 2 0 Sensor protein DegS Baculo_PEP_C PF04513.12 EXF77724.1 - 2.4 8.2 5.4 0.33 11.0 0.9 1.8 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4232 PF14016.6 EXF77725.1 - 0.016 15.4 0.1 0.02 15.0 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4232) SpaA PF17802.1 EXF77725.1 - 0.093 13.1 0.1 0.17 12.2 0.1 1.4 1 0 0 1 1 1 0 Prealbumin-like fold domain TFIIB PF00382.19 EXF77726.1 - 0.00042 20.3 0.0 1.2 9.3 0.0 2.5 2 0 0 2 2 2 2 Transcription factor TFIIB repeat Cyclin_N PF00134.23 EXF77726.1 - 0.005 16.6 0.0 0.11 12.2 0.0 2.3 2 0 0 2 2 2 1 Cyclin, N-terminal domain Vps5 PF09325.10 EXF77727.1 - 2.2e-11 43.8 1.7 3.8e-11 43.0 1.7 1.2 1 0 0 1 1 1 1 Vps5 C terminal like PX PF00787.24 EXF77727.1 - 1.3e-10 41.3 0.0 2.9e-10 40.1 0.0 1.6 1 0 0 1 1 1 1 PX domain NST1 PF13945.6 EXF77727.1 - 0.31 11.1 4.4 0.082 13.0 1.2 1.6 2 0 0 2 2 2 0 Salt tolerance down-regulator ADH_N PF08240.12 EXF77728.1 - 4.6e-27 94.0 1.5 1e-26 93.0 1.5 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EXF77728.1 - 1.8e-16 60.3 1.0 1.9e-15 57.0 1.0 2.2 1 1 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EXF77728.1 - 5.9e-09 35.7 1.0 0.00018 21.1 0.1 2.6 2 1 0 2 2 2 2 Glucose dehydrogenase C-terminus AlaDh_PNT_C PF01262.21 EXF77728.1 - 0.00059 19.2 0.5 0.001 18.4 0.5 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain ADH_zinc_N_2 PF13602.6 EXF77728.1 - 0.0035 18.4 0.0 0.0091 17.1 0.0 1.8 1 1 0 1 1 1 1 Zinc-binding dehydrogenase UDPG_MGDP_dh_N PF03721.14 EXF77728.1 - 0.0058 16.2 0.6 0.011 15.4 0.2 1.6 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain ThiF PF00899.21 EXF77728.1 - 0.023 14.0 0.1 0.04 13.3 0.1 1.3 1 0 0 1 1 1 0 ThiF family ApbA PF02558.16 EXF77728.1 - 0.032 13.9 0.0 0.051 13.2 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Pyr_redox_2 PF07992.14 EXF77728.1 - 0.033 13.4 0.2 0.08 12.2 0.1 1.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EXF77728.1 - 0.034 14.4 1.5 0.085 13.1 0.6 2.1 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain 3HCDH_N PF02737.18 EXF77728.1 - 0.043 13.7 0.4 0.066 13.1 0.4 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NADH_4Fe-4S PF10589.9 EXF77728.1 - 0.062 13.4 0.8 0.18 11.9 0.5 1.9 2 0 0 2 2 1 0 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region Shikimate_DH PF01488.20 EXF77728.1 - 0.064 13.3 0.1 0.14 12.2 0.1 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase TrkA_N PF02254.18 EXF77728.1 - 0.074 13.3 0.1 0.13 12.5 0.1 1.3 1 0 0 1 1 1 0 TrkA-N domain DUF281 PF03436.13 EXF77728.1 - 0.087 13.2 0.8 1.6 9.2 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF281) AdoHcyase_NAD PF00670.21 EXF77728.1 - 0.15 12.1 0.4 0.28 11.2 0.4 1.4 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain MitMem_reg PF13012.6 EXF77729.1 - 2.9e-10 40.6 1.7 1.1e-09 38.7 1.7 1.9 1 1 0 1 1 1 1 Maintenance of mitochondrial structure and function JAB PF01398.21 EXF77729.1 - 2.6e-06 27.4 0.0 6.1e-06 26.2 0.0 1.6 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease QueH PF02677.14 EXF77730.1 - 0.19 11.8 0.3 0.46 10.6 0.2 1.6 2 0 0 2 2 2 0 Epoxyqueuosine reductase QueH MFS_1 PF07690.16 EXF77732.1 - 9.1e-05 21.5 26.1 9.1e-05 21.5 26.1 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily UNC-93 PF05978.16 EXF77732.1 - 0.00013 21.7 3.0 0.00013 21.7 3.0 2.6 3 0 0 3 3 3 1 Ion channel regulatory protein UNC-93 EXS PF03124.14 EXF77732.1 - 0.0074 15.7 0.4 0.016 14.6 0.4 1.5 1 0 0 1 1 1 1 EXS family RVT_1 PF00078.27 EXF77734.1 - 5.5e-21 75.1 0.0 1e-20 74.3 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 EXF77734.1 - 0.0096 15.8 0.7 0.035 13.9 0.0 2.2 3 0 0 3 3 3 1 Endonuclease-reverse transcriptase BCIP PF13862.6 EXF77735.1 - 7.2e-68 228.4 0.1 9.4e-68 228.1 0.1 1.1 1 0 0 1 1 1 1 p21-C-terminal region-binding protein CM_2 PF01817.21 EXF77736.1 - 0.06 13.7 2.1 8.2 6.9 0.1 2.7 2 2 0 2 2 2 0 Chorismate mutase type II WD40 PF00400.32 EXF77737.1 - 4.1e-30 103.4 9.1 6.8e-07 29.9 0.5 6.0 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EXF77737.1 - 1.5e-08 34.8 0.1 0.12 12.7 0.0 4.8 3 2 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EXF77737.1 - 1.1e-05 24.3 6.0 0.024 13.3 0.3 4.7 3 2 2 5 5 5 3 Nucleoporin Nup120/160 DUF5082 PF16888.5 EXF77737.1 - 0.028 14.7 0.2 0.067 13.5 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5082) APG6_N PF17675.1 EXF77737.1 - 0.11 13.0 3.0 0.27 11.8 3.0 1.7 1 0 0 1 1 1 0 Apg6 coiled-coil region DUF2046 PF09755.9 EXF77738.1 - 0.023 13.9 6.3 0.051 12.8 0.5 2.7 3 0 0 3 3 3 0 Uncharacterized conserved protein H4 (DUF2046) Clr5 PF14420.6 EXF77738.1 - 0.026 14.7 0.6 0.054 13.7 0.0 1.7 2 0 0 2 2 1 0 Clr5 domain bZIP_1 PF00170.21 EXF77738.1 - 0.055 13.6 15.7 0.39 10.9 7.0 2.8 2 1 0 2 2 2 0 bZIP transcription factor BLOC1_2 PF10046.9 EXF77738.1 - 0.27 11.5 7.1 0.69 10.3 1.9 2.6 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 GCN5L1 PF06320.13 EXF77738.1 - 0.36 11.0 5.3 7.3 6.8 1.8 2.8 2 0 0 2 2 2 0 GCN5-like protein 1 (GCN5L1) Herpes_UL6 PF01763.16 EXF77738.1 - 0.43 9.0 3.0 0.96 7.9 3.0 1.6 1 1 0 1 1 1 0 Herpesvirus UL6 like Sec34 PF04136.15 EXF77738.1 - 0.51 10.2 2.7 0.86 9.5 0.3 2.2 2 0 0 2 2 2 0 Sec34-like family KASH_CCD PF14662.6 EXF77738.1 - 0.76 9.6 10.9 1.8 8.3 3.7 2.5 2 0 0 2 2 2 0 Coiled-coil region of CCDC155 or KASH Cep57_CLD_2 PF14197.6 EXF77738.1 - 0.94 9.6 8.9 0.21 11.7 3.3 2.5 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 CENP-Q PF13094.6 EXF77738.1 - 1.1 9.4 21.0 0.1 12.8 7.5 3.8 3 0 0 3 3 3 0 CENP-Q, a CENPA-CAD centromere complex subunit GAS PF13851.6 EXF77738.1 - 1.1 8.5 15.8 0.41 10.0 7.1 2.4 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding DUF4446 PF14584.6 EXF77738.1 - 2.9 7.9 5.0 7.9 6.4 1.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) Prefoldin_2 PF01920.20 EXF77738.1 - 3 7.8 12.2 11 6.1 4.2 2.6 2 0 0 2 2 2 0 Prefoldin subunit RNF220 PF15926.5 EXF77738.1 - 3.2 7.3 6.0 0.41 10.2 0.8 2.1 2 0 0 2 2 2 0 E3 ubiquitin-protein ligase RNF220 Ax_dynein_light PF10211.9 EXF77738.1 - 4.7 7.1 11.8 3.5 7.5 5.3 2.5 2 0 0 2 2 2 0 Axonemal dynein light chain YabA PF06156.13 EXF77738.1 - 7.3 7.3 9.2 24 5.6 2.4 2.7 2 0 0 2 2 2 0 Initiation control protein YabA VASt PF16016.5 EXF77739.1 - 1.5e-37 129.3 0.0 2.8e-37 128.5 0.0 1.5 1 0 0 1 1 1 1 VAD1 Analog of StAR-related lipid transfer domain GRAM PF02893.20 EXF77739.1 - 4.2e-24 84.6 0.0 6.8e-24 83.9 0.0 1.3 1 0 0 1 1 1 1 GRAM domain Dynamin_N PF00350.23 EXF77740.1 - 7.2e-33 114.0 0.5 1.6e-32 112.9 0.1 1.8 2 0 0 2 2 2 1 Dynamin family Dynamin_M PF01031.20 EXF77740.1 - 4.5e-25 88.5 0.9 1.4e-21 76.9 0.0 2.3 1 1 0 2 2 2 2 Dynamin central region GED PF02212.18 EXF77740.1 - 0.00061 19.9 1.8 0.0012 18.9 0.1 2.3 2 0 0 2 2 2 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 EXF77740.1 - 0.0013 18.8 0.2 0.023 14.7 0.3 2.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.16 EXF77740.1 - 0.074 12.4 0.1 2.9 7.2 0.2 2.5 2 0 0 2 2 2 0 AIG1 family GCFC PF07842.12 EXF77740.1 - 0.084 12.5 0.7 0.14 11.7 0.1 1.6 2 0 0 2 2 2 0 GC-rich sequence DNA-binding factor-like protein FeoB_N PF02421.18 EXF77740.1 - 0.11 12.0 0.1 9.5 5.7 0.1 2.3 2 0 0 2 2 2 0 Ferrous iron transport protein B FTCD_C PF04961.12 EXF77740.1 - 0.16 11.8 0.2 9.5 5.9 0.0 2.9 3 0 0 3 3 3 0 Formiminotransferase-cyclodeaminase MFS_1 PF07690.16 EXF77741.1 - 2.8e-34 118.6 28.9 2.8e-34 118.6 28.9 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF77741.1 - 9.5e-15 54.4 17.6 1.3e-14 53.9 17.6 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter adh_short_C2 PF13561.6 EXF77742.1 - 5.8e-53 179.8 0.0 7.4e-53 179.5 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF77742.1 - 1.1e-45 155.6 0.1 1.3e-45 155.2 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EXF77742.1 - 4.9e-09 36.4 0.1 6.7e-09 35.9 0.1 1.2 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EXF77742.1 - 0.012 14.8 0.0 0.015 14.4 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Epimerase PF01370.21 EXF77742.1 - 0.021 14.3 0.0 0.034 13.6 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family p450 PF00067.22 EXF77743.1 - 1.1e-36 126.6 0.0 1.7e-36 126.0 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 Rhodanese PF00581.20 EXF77744.1 - 6.2e-07 29.9 0.0 1.8e-06 28.4 0.0 1.8 1 0 0 1 1 1 1 Rhodanese-like domain Homeodomain PF00046.29 EXF77744.1 - 3.9e-05 23.4 0.3 9.3e-05 22.2 0.3 1.6 1 0 0 1 1 1 1 Homeodomain PIG-X PF08320.12 EXF77745.1 - 6.5e-70 235.3 0.0 9.8e-70 234.7 0.0 1.3 1 0 0 1 1 1 1 PIG-X / PBN1 2OG-FeII_Oxy_3 PF13640.6 EXF77746.1 - 1.9e-08 35.1 0.0 4.9e-08 33.8 0.0 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Fungal_trans PF04082.18 EXF77747.1 - 0.021 13.9 0.3 0.039 13.0 0.3 1.4 1 0 0 1 1 1 0 Fungal specific transcription factor domain T2SSF PF00482.23 EXF77747.1 - 0.038 14.0 0.0 0.093 12.7 0.0 1.6 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein F AAA_18 PF13238.6 EXF77748.1 - 1.2e-08 35.6 0.0 2.3e-08 34.7 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EXF77748.1 - 4.3e-06 26.9 0.0 6.4e-06 26.4 0.0 1.2 1 0 0 1 1 1 1 AAA domain APS_kinase PF01583.20 EXF77748.1 - 0.00046 20.1 0.0 0.00076 19.4 0.0 1.5 1 1 0 1 1 1 1 Adenylylsulphate kinase AAA_5 PF07728.14 EXF77748.1 - 0.026 14.5 0.0 0.8 9.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EXF77748.1 - 0.055 13.8 0.0 0.078 13.4 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain Ploopntkinase3 PF18751.1 EXF77748.1 - 0.096 12.6 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 PBP PF01161.20 EXF77749.1 - 1.2e-16 61.2 0.0 1.9e-16 60.6 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein PrpF PF04303.13 EXF77750.1 - 2.5e-86 289.9 0.0 3.3e-86 289.6 0.0 1.1 1 0 0 1 1 1 1 PrpF protein Bac_export_2 PF01312.19 EXF77751.1 - 0.21 10.8 0.6 0.33 10.1 0.4 1.4 1 1 0 1 1 1 0 FlhB HrpN YscU SpaS Family DUF4118 PF13493.6 EXF77751.1 - 0.97 9.3 12.4 0.02 14.6 3.6 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4118) DUF5527 PF17665.1 EXF77751.1 - 8.2 6.0 5.4 1.4 8.5 0.2 2.3 2 1 0 2 2 2 0 Family of unknown function (DUF5527) GMC_oxred_N PF00732.19 EXF77752.1 - 2.8e-57 194.4 0.0 3.7e-57 193.9 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EXF77752.1 - 5.2e-38 130.8 0.0 9.1e-38 130.0 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase NAD_binding_8 PF13450.6 EXF77752.1 - 0.0012 19.0 0.0 0.0031 17.7 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EXF77752.1 - 0.016 14.4 0.2 0.78 8.9 0.1 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EXF77752.1 - 0.041 12.9 0.3 0.069 12.2 0.3 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein DAO PF01266.24 EXF77752.1 - 0.09 12.3 2.9 0.53 9.8 2.9 2.2 1 1 0 1 1 1 0 FAD dependent oxidoreductase GGACT PF06094.12 EXF77753.1 - 1.5e-07 32.1 0.0 1.4e-06 28.9 0.0 2.0 1 1 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like AIG2_2 PF13772.6 EXF77753.1 - 2e-07 31.3 0.0 6.6e-07 29.6 0.0 1.9 1 1 0 1 1 1 1 AIG2-like family LacAB_rpiB PF02502.18 EXF77754.1 - 1.2e-45 154.9 0.1 1.4e-45 154.7 0.1 1.0 1 0 0 1 1 1 1 Ribose/Galactose Isomerase F_bP_aldolase PF01116.20 EXF77755.1 - 5.8e-85 285.2 0.6 6.5e-85 285.0 0.6 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II CobS PF02654.15 EXF77755.1 - 0.056 13.6 0.6 0.36 11.0 0.0 2.0 2 0 0 2 2 2 0 Cobalamin-5-phosphate synthase Fungal_trans_2 PF11951.8 EXF77756.1 - 6.7e-11 41.6 0.0 1.6e-10 40.4 0.0 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF77756.1 - 4.9e-07 29.8 7.3 9.7e-07 28.8 7.3 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Dak1 PF02733.17 EXF77757.1 - 1.2e-102 343.0 0.0 4.5e-102 341.1 0.0 1.8 2 0 0 2 2 2 1 Dak1 domain Dak2 PF02734.17 EXF77757.1 - 1e-36 126.5 0.3 1.7e-36 125.8 0.3 1.4 1 0 0 1 1 1 1 DAK2 domain Sugar_tr PF00083.24 EXF77761.1 - 5.1e-49 167.4 11.3 6.6e-49 167.0 11.3 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF77761.1 - 2.6e-23 82.5 22.1 5.4e-23 81.5 22.0 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily Abhydrolase_1 PF00561.20 EXF77762.1 - 3.5e-46 157.9 0.0 6.4e-46 157.1 0.0 1.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EXF77762.1 - 0.019 15.6 4.6 0.039 14.6 4.6 1.7 1 1 0 1 1 1 0 Alpha/beta hydrolase family THOC2_N PF16134.5 EXF77763.1 - 4.6e-246 818.4 0.0 7.4e-246 817.7 0.0 1.3 1 0 0 1 1 1 1 THO complex subunit 2 N-terminus Tho2 PF11262.8 EXF77763.1 - 1.2e-94 316.9 0.0 2.8e-94 315.7 0.0 1.7 1 0 0 1 1 1 1 Transcription factor/nuclear export subunit protein 2 Thoc2 PF11732.8 EXF77763.1 - 4.1e-27 94.0 0.1 8.7e-27 93.0 0.1 1.6 1 0 0 1 1 1 1 Transcription- and export-related complex subunit Glyco_transf_34 PF05637.12 EXF77765.1 - 2.3e-19 70.1 0.0 3.6e-19 69.4 0.0 1.2 1 0 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family LSPR PF06049.12 EXF77765.1 - 0.089 12.7 0.9 0.32 11.0 0.9 2.0 1 0 0 1 1 1 0 Coagulation Factor V LSPD Repeat MBOAT_2 PF13813.6 EXF77766.1 - 0.0044 17.3 0.4 0.017 15.4 0.4 2.0 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family Pox_A14 PF05767.12 EXF77766.1 - 0.1 12.8 0.3 0.1 12.8 0.3 3.1 3 0 0 3 3 3 0 Poxvirus virion envelope protein A14 Zn_clus PF00172.18 EXF77767.1 - 0.0079 16.3 8.7 0.017 15.3 8.7 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RSN1_7TM PF02714.15 EXF77768.1 - 3.5e-84 282.4 28.4 3.5e-84 282.4 28.4 1.7 2 0 0 2 2 2 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 EXF77768.1 - 1.8e-44 151.3 1.0 1.8e-44 151.3 1.0 3.1 5 0 0 5 5 5 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 EXF77768.1 - 5e-37 127.8 0.2 7.2e-37 127.3 0.2 1.2 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter PHM7_ext PF12621.8 EXF77768.1 - 5.6e-31 106.6 0.2 1.5e-30 105.2 0.1 1.7 2 0 0 2 2 2 1 Extracellular tail, of 10TM putative phosphate transporter kleA_kleC PF17383.2 EXF77768.1 - 0.13 12.6 2.3 0.36 11.2 0.6 2.3 2 0 0 2 2 2 0 Uncharacterized KorC regulated protein A MICSWaP PF17018.5 EXF77769.1 - 0.047 13.3 0.0 0.083 12.4 0.0 1.3 1 0 0 1 1 1 0 Spore wall protein Solute_trans_a PF03619.16 EXF77771.1 - 3.9e-86 288.8 24.6 4.7e-86 288.6 24.6 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha WSC PF01822.19 EXF77772.1 - 1.6e-11 44.2 8.8 1.6e-11 44.2 8.8 2.0 2 0 0 2 2 2 1 WSC domain SKG6 PF08693.10 EXF77772.1 - 0.00016 21.0 1.4 0.00045 19.6 1.4 1.8 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Trp_oprn_chp PF09534.10 EXF77772.1 - 0.0025 17.6 0.6 0.0081 16.0 0.5 1.9 1 1 0 1 1 1 1 Tryptophan-associated transmembrane protein (Trp_oprn_chp) PTP_tm PF18861.1 EXF77772.1 - 0.0086 16.1 0.1 0.013 15.5 0.1 1.3 1 0 0 1 1 1 1 Transmembrane domain of protein tyrosine phosphatase, receptor type J Gram_pos_anchor PF00746.21 EXF77772.1 - 0.0098 15.8 0.2 0.023 14.6 0.2 1.6 1 0 0 1 1 1 1 LPXTG cell wall anchor motif Adeno_E3_CR2 PF02439.15 EXF77772.1 - 0.029 14.1 0.0 0.066 13.0 0.0 1.6 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 DUF2207 PF09972.9 EXF77772.1 - 0.059 12.1 0.0 0.079 11.7 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF4366 PF14283.6 EXF77772.1 - 0.062 13.4 0.5 0.19 11.8 0.5 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4366) DUF2613 PF11021.8 EXF77772.1 - 0.069 13.3 0.2 0.069 13.3 0.2 2.6 3 1 0 3 3 3 0 Protein of unknown function (DUF2613) EphA2_TM PF14575.6 EXF77772.1 - 0.078 13.9 0.0 0.18 12.7 0.0 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF1180 PF06679.12 EXF77772.1 - 0.14 12.6 5.4 0.25 11.8 5.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Podoplanin PF05808.11 EXF77772.1 - 2.8 8.0 19.3 7.8 6.6 19.4 1.7 1 1 0 1 1 1 0 Podoplanin TMEM154 PF15102.6 EXF77772.1 - 3.3 7.6 10.7 6.5 6.7 7.4 2.4 2 1 0 2 2 2 0 TMEM154 protein family PI-PLC-X PF00388.19 EXF77773.1 - 3.9e-07 29.7 0.0 6.2e-07 29.1 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain Dynamin_N PF00350.23 EXF77774.1 - 3.2e-09 37.1 0.0 5e-08 33.2 0.0 2.3 1 1 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 EXF77774.1 - 2.7e-05 24.2 0.1 0.014 15.5 0.1 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EXF77774.1 - 9e-05 22.4 0.1 0.00041 20.3 0.0 2.1 2 0 0 2 2 2 1 RsgA GTPase AAA_16 PF13191.6 EXF77774.1 - 0.0012 19.2 0.2 0.0051 17.2 0.0 2.2 2 0 0 2 2 2 1 AAA ATPase domain ABC_tran PF00005.27 EXF77774.1 - 0.0037 17.8 0.0 0.035 14.6 0.0 2.4 2 0 0 2 2 2 1 ABC transporter AAA_22 PF13401.6 EXF77774.1 - 0.014 15.7 0.0 0.07 13.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain Roc PF08477.13 EXF77774.1 - 0.17 12.1 0.1 0.44 10.8 0.1 1.7 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Pectate_lyase PF03211.13 EXF77775.1 - 9.3e-84 280.0 13.9 1.1e-83 279.8 13.9 1.0 1 0 0 1 1 1 1 Pectate lyase TPR_2 PF07719.17 EXF77776.1 - 1e-13 50.2 11.5 0.00026 20.8 0.0 6.2 6 0 0 6 6 5 4 Tetratricopeptide repeat TPR_1 PF00515.28 EXF77776.1 - 2e-10 40.0 8.3 0.0022 17.8 0.0 6.0 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_8 PF13181.6 EXF77776.1 - 6.7e-07 29.0 1.1 1.6 9.2 0.0 5.7 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_16 PF13432.6 EXF77776.1 - 1.5e-06 28.8 13.1 0.32 11.7 0.0 6.2 7 1 1 8 8 6 3 Tetratricopeptide repeat TPR_19 PF14559.6 EXF77776.1 - 1.1e-05 25.9 5.9 0.0018 18.8 0.0 4.4 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 EXF77776.1 - 5.8e-05 23.3 4.5 0.015 15.5 0.8 4.4 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.6 EXF77776.1 - 7.2e-05 22.4 0.0 28 4.5 0.0 6.0 6 0 0 6 6 6 0 TPR repeat TPR_17 PF13431.6 EXF77776.1 - 0.00015 21.9 2.4 19 5.9 0.0 5.9 5 1 0 5 5 5 0 Tetratricopeptide repeat TPR_7 PF13176.6 EXF77776.1 - 0.00067 19.5 1.1 3.1 8.0 0.1 4.1 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 EXF77776.1 - 0.003 18.2 10.7 11 7.1 0.1 6.9 7 1 1 8 8 6 1 Tetratricopeptide repeat TPR_4 PF07721.14 EXF77776.1 - 0.0054 17.2 14.1 0.13 13.0 1.6 4.7 6 0 0 6 6 4 2 Tetratricopeptide repeat TPR_6 PF13174.6 EXF77776.1 - 0.031 14.9 3.0 35 5.3 0.0 5.5 6 0 0 6 6 6 0 Tetratricopeptide repeat HrpB1_HrpK PF09613.10 EXF77776.1 - 0.038 13.6 0.0 23 4.7 0.0 3.4 3 0 0 3 3 3 0 Bacterial type III secretion protein (HrpB1_HrpK) TPR_10 PF13374.6 EXF77776.1 - 0.35 10.8 6.5 48 4.0 0.2 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EXF77776.1 - 3.8 7.8 5.5 70 3.7 0.1 4.2 3 1 1 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 AA_permease_2 PF13520.6 EXF77777.1 - 8.8e-52 176.4 49.3 1e-51 176.1 49.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EXF77777.1 - 5.1e-23 81.4 43.2 6.9e-23 81.0 43.2 1.1 1 0 0 1 1 1 1 Amino acid permease p450 PF00067.22 EXF77778.1 - 3.8e-38 131.4 0.0 4.9e-38 131.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Peptidase_S9 PF00326.21 EXF77779.1 - 2.4e-48 164.4 0.9 4.1e-48 163.7 0.9 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family DPPIV_N PF00930.21 EXF77779.1 - 6.3e-42 143.6 0.0 1.4e-41 142.5 0.0 1.5 1 1 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region VHL PF01847.16 EXF77779.1 - 9.8e-10 38.2 0.0 2.2e-09 37.1 0.0 1.6 1 0 0 1 1 1 1 VHL beta domain Peptidase_S15 PF02129.18 EXF77779.1 - 4.5e-07 29.7 1.2 2.9e-06 27.1 1.1 2.0 1 1 1 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) DLH PF01738.18 EXF77779.1 - 0.00021 20.9 0.0 0.00042 19.9 0.0 1.4 1 0 0 1 1 1 1 Dienelactone hydrolase family Hydrolase_4 PF12146.8 EXF77779.1 - 0.031 13.5 0.1 0.23 10.7 0.0 2.1 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.13 EXF77779.1 - 0.28 11.0 2.0 7 6.4 2.0 2.2 1 1 0 1 1 1 0 alpha/beta hydrolase fold Fungal_trans_2 PF11951.8 EXF77780.1 - 3.3e-24 85.4 0.6 1.2e-11 44.1 0.3 2.1 2 0 0 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF77780.1 - 9.7e-08 32.0 14.2 2.2e-07 30.9 14.2 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PhyH PF05721.13 EXF77781.1 - 1.7e-24 87.2 0.0 2.4e-24 86.8 0.0 1.2 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) MFS_1 PF07690.16 EXF77782.1 - 1.3e-34 119.7 41.0 1.3e-34 119.7 41.0 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily LSM PF01423.22 EXF77783.1 - 1e-15 57.1 0.1 3.2e-15 55.6 0.0 1.9 2 0 0 2 2 2 1 LSM domain PPR_2 PF13041.6 EXF77783.1 - 0.0012 19.0 0.0 17 5.7 0.0 5.1 5 1 1 6 6 6 1 PPR repeat family SM-ATX PF14438.6 EXF77783.1 - 0.12 12.5 0.0 0.33 11.1 0.0 1.7 1 0 0 1 1 1 0 Ataxin 2 SM domain PPR PF01535.20 EXF77783.1 - 0.22 11.8 3.9 16 6.0 0.0 4.6 6 0 0 6 6 6 0 PPR repeat Sulfatase PF00884.23 EXF77784.1 - 2.3e-61 207.9 0.8 2.3e-61 207.9 0.8 1.4 2 0 0 2 2 2 1 Sulfatase Phosphodiest PF01663.22 EXF77784.1 - 7.3e-06 25.8 0.6 1.5e-05 24.8 0.6 1.4 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase DUF229 PF02995.17 EXF77784.1 - 0.0028 16.3 0.0 0.0046 15.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF229) DUF4976 PF16347.5 EXF77784.1 - 0.032 14.5 0.0 0.079 13.2 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4976) DUF1501 PF07394.12 EXF77784.1 - 0.037 13.1 0.0 0.06 12.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) MFS_1 PF07690.16 EXF77785.1 - 9.9e-38 130.0 32.5 9.9e-38 130.0 32.5 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF77785.1 - 1.5e-13 50.4 18.7 4.6e-13 48.9 18.7 1.8 1 1 0 1 1 1 1 Sugar (and other) transporter TRI12 PF06609.13 EXF77785.1 - 2.1e-08 33.1 5.9 3.2e-08 32.5 5.9 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) TgMIC1 PF11476.8 EXF77786.1 - 0.026 14.3 0.0 0.031 14.0 0.0 1.1 1 0 0 1 1 1 0 Toxoplasma gondii micronemal protein 1 TgMIC1 Peptidase_M20 PF01546.28 EXF77787.1 - 0.071 12.8 0.0 0.071 12.8 0.0 1.2 1 0 0 1 1 1 0 Peptidase family M20/M25/M40 MR_MLE_C PF13378.6 EXF77787.1 - 0.074 12.6 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 Enolase C-terminal domain-like ketoacyl-synt PF00109.26 EXF77788.1 - 2.3e-68 230.5 0.0 4.7e-68 229.5 0.0 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 EXF77788.1 - 1.3e-59 202.3 0.0 2.3e-59 201.5 0.0 1.4 1 0 0 1 1 1 1 Acyl transferase domain PS-DH PF14765.6 EXF77788.1 - 8.7e-57 192.6 0.0 1.3e-56 192.0 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase KR PF08659.10 EXF77788.1 - 2.9e-55 186.9 0.1 7.7e-55 185.6 0.1 1.7 2 0 0 2 2 2 1 KR domain Ketoacyl-synt_C PF02801.22 EXF77788.1 - 6.8e-31 106.7 0.0 1.4e-30 105.7 0.0 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 EXF77788.1 - 1.4e-24 86.7 0.0 3.3e-24 85.5 0.0 1.7 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension ADH_zinc_N PF00107.26 EXF77788.1 - 1.3e-09 38.1 0.0 8.2e-09 35.5 0.0 2.4 2 0 0 2 2 2 1 Zinc-binding dehydrogenase adh_short PF00106.25 EXF77788.1 - 1e-07 31.6 0.0 2.3e-07 30.4 0.0 1.6 1 0 0 1 1 1 1 short chain dehydrogenase Thiolase_N PF00108.23 EXF77788.1 - 0.0018 17.7 0.0 0.0034 16.8 0.0 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain Methyltransf_31 PF13847.6 EXF77788.1 - 0.038 13.8 0.0 0.09 12.6 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain adh_short_C2 PF13561.6 EXF77788.1 - 0.062 12.9 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase Methyltransf_11 PF08241.12 EXF77788.1 - 0.066 13.9 0.0 0.25 12.0 0.0 2.0 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.6 EXF77788.1 - 0.16 11.8 0.0 0.49 10.2 0.0 1.9 1 0 0 1 1 1 0 Methyltransferase domain AMP-binding PF00501.28 EXF77789.1 - 2.4e-87 293.3 0.0 3.6e-87 292.7 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EXF77789.1 - 8.2e-20 71.6 0.1 2.6e-19 70.0 0.0 1.9 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain p450 PF00067.22 EXF77790.1 - 2.9e-43 148.3 0.0 4.8e-42 144.3 0.0 2.0 1 1 0 1 1 1 1 Cytochrome P450 ANP PF00212.18 EXF77790.1 - 0.13 12.5 0.1 0.37 11.0 0.1 1.8 1 0 0 1 1 1 0 Atrial natriuretic peptide Fungal_trans PF04082.18 EXF77791.1 - 5e-28 97.9 0.0 7.6e-28 97.3 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain MFS_1 PF07690.16 EXF77792.1 - 7.7e-44 150.0 50.4 5.6e-43 147.2 50.4 2.1 1 1 0 1 1 1 1 Major Facilitator Superfamily OATP PF03137.20 EXF77792.1 - 0.038 12.3 0.2 0.038 12.3 0.2 2.7 2 1 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.16 EXF77793.1 - 1.4e-21 76.8 19.0 4.8e-21 75.1 19.4 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily DUF1523 PF07509.11 EXF77793.1 - 0.061 12.7 0.0 0.13 11.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1523) TPPK_C PF12555.8 EXF77793.1 - 0.72 9.9 3.9 0.38 10.8 0.2 2.5 2 0 0 2 2 2 0 Thiamine pyrophosphokinase C terminal Dioxygenase_C PF00775.21 EXF77794.1 - 5.9e-08 32.4 0.0 2.5e-06 27.1 0.0 2.4 2 0 0 2 2 2 2 Dioxygenase Lipoxygenase PF00305.19 EXF77795.1 - 2.8e-28 98.8 0.0 4.1e-28 98.2 0.0 1.3 1 0 0 1 1 1 1 Lipoxygenase Amidohydro_1 PF01979.20 EXF77796.1 - 1.9e-75 254.3 0.0 2.3e-75 254.1 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EXF77796.1 - 2.6e-08 33.8 2.4 4.4e-06 26.4 0.1 2.3 1 1 0 2 2 2 2 Amidohydrolase family DUF2802 PF10975.8 EXF77796.1 - 0.067 13.3 0.2 0.46 10.7 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2802) DUF1729 PF08354.10 EXF77797.1 - 6e-153 508.9 0.0 8.9e-153 508.3 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1729) Acyl_transf_1 PF00698.21 EXF77797.1 - 3.7e-89 299.4 0.0 6.3e-88 295.3 0.0 2.7 3 0 0 3 3 3 1 Acyl transferase domain FAS_meander PF17951.1 EXF77797.1 - 1.3e-55 187.2 0.0 4.5e-55 185.5 0.0 2.0 2 0 0 2 2 2 1 Fatty acid synthase meander beta sheet domain FAS_N PF17828.1 EXF77797.1 - 3.2e-40 137.1 0.0 6.7e-40 136.1 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain in fatty acid synthase subunit beta MaoC_dehydratas PF01575.19 EXF77797.1 - 5.1e-38 129.4 0.0 1.1e-37 128.3 0.0 1.6 1 0 0 1 1 1 1 MaoC like domain SAT PF16073.5 EXF77797.1 - 5.5e-36 124.5 0.0 1.6e-35 122.9 0.0 1.8 2 0 0 2 2 2 1 Starter unit:ACP transacylase in aflatoxin biosynthesis MaoC_dehydrat_N PF13452.6 EXF77797.1 - 4e-24 85.2 0.0 1.4e-23 83.5 0.0 2.0 1 0 0 1 1 1 1 N-terminal half of MaoC dehydratase NMO PF03060.15 EXF77797.1 - 0.00076 19.0 0.1 0.0051 16.2 0.1 2.2 1 1 0 1 1 1 1 Nitronate monooxygenase FAS_I_H PF18314.1 EXF77798.1 - 1.6e-78 263.0 0.6 3.3e-78 262.0 0.1 1.9 2 0 0 2 2 2 1 Fatty acid synthase type I helical domain Fas_alpha_ACP PF18325.1 EXF77798.1 - 3.5e-75 251.8 0.0 7.2e-75 250.8 0.0 1.6 1 0 0 1 1 1 1 Fatty acid synthase subunit alpha Acyl carrier domain ketoacyl-synt PF00109.26 EXF77798.1 - 2.3e-20 73.3 0.1 4.8e-20 72.2 0.1 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain ACPS PF01648.20 EXF77798.1 - 3.2e-19 69.1 0.0 7.5e-19 68.0 0.0 1.7 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily Ketoacyl-synt_C PF02801.22 EXF77798.1 - 9.1e-12 45.0 0.1 3e-11 43.3 0.0 1.9 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain adh_short PF00106.25 EXF77798.1 - 6.8e-05 22.4 0.0 0.00018 21.1 0.0 1.7 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EXF77798.1 - 0.011 15.6 0.0 0.036 14.0 0.0 1.8 1 0 0 1 1 1 0 KR domain Ribosomal_S4 PF00163.19 EXF77798.1 - 0.1 13.5 0.3 0.38 11.7 0.3 2.0 1 0 0 1 1 1 0 Ribosomal protein S4/S9 N-terminal domain Macoilin PF09726.9 EXF77799.1 - 0.018 13.6 15.5 0.027 13.1 15.5 1.2 1 0 0 1 1 1 0 Macoilin family DUF4875 PF16175.5 EXF77799.1 - 0.079 13.1 1.7 3.4 7.8 1.0 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4875) Cyt-b5 PF00173.28 EXF77800.1 - 1.1e-09 38.3 0.0 1.6e-09 37.8 0.0 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Cu_bind_like PF02298.17 EXF77801.1 - 0.025 14.6 0.1 0.09 12.8 0.1 1.9 1 1 0 1 1 1 0 Plastocyanin-like domain Cupredoxin_1 PF13473.6 EXF77801.1 - 0.053 13.6 0.2 0.32 11.1 0.1 1.9 1 1 0 2 2 2 0 Cupredoxin-like domain DUF2263 PF10021.9 EXF77801.1 - 0.13 12.7 0.3 0.2 12.0 0.3 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2263) CENP-X PF09415.10 EXF77802.1 - 6.6e-24 84.0 0.0 6.6e-24 84.0 0.0 1.9 2 0 0 2 2 2 1 CENP-S associating Centromere protein X DUF4746 PF15928.5 EXF77802.1 - 0.43 10.0 5.4 0.55 9.6 5.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Astro_capsid_p PF12226.8 EXF77802.1 - 2.3 7.3 4.4 3 6.9 4.4 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein NOA36 PF06524.12 EXF77802.1 - 4.1 6.6 6.6 5.8 6.2 6.6 1.2 1 0 0 1 1 1 0 NOA36 protein DNA_pol_phi PF04931.13 EXF77802.1 - 9.6 4.2 7.0 10 4.1 7.0 1.1 1 0 0 1 1 1 0 DNA polymerase phi Mito_carr PF00153.27 EXF77803.1 - 1.2e-64 214.3 3.8 8.8e-24 83.3 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF4748 PF15932.5 EXF77803.1 - 0.11 12.3 0.6 0.37 10.6 0.6 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4748) Bromodomain PF00439.25 EXF77804.1 - 0.00019 21.4 0.0 0.00071 19.6 0.0 1.8 1 1 0 1 1 1 1 Bromodomain adh_short PF00106.25 EXF77805.1 - 2.7e-21 75.9 0.3 1.1e-19 70.7 0.3 2.1 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF77805.1 - 1.9e-14 53.8 0.4 1.3e-08 34.7 0.0 2.3 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF77805.1 - 3.8e-07 30.2 0.0 6.2e-07 29.5 0.0 1.4 1 0 0 1 1 1 1 KR domain Cation_ATPase_C PF00689.21 EXF77806.1 - 2.4e-45 154.5 9.1 2.4e-45 154.5 9.1 2.1 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 EXF77806.1 - 8.5e-33 113.4 0.1 8.5e-33 113.4 0.1 2.7 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase PF13246.6 EXF77806.1 - 2.7e-20 72.3 0.0 8e-20 70.7 0.0 1.9 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EXF77806.1 - 2e-18 67.5 0.5 1.4e-15 58.2 0.0 2.6 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EXF77806.1 - 7.9e-06 25.5 0.0 2.7e-05 23.8 0.0 1.9 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EXF77806.1 - 0.0017 18.2 0.3 0.0031 17.3 0.3 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Tautomerase_3 PF14832.6 EXF77807.1 - 1.1e-12 48.4 0.0 1.4e-12 48.0 0.0 1.3 1 0 0 1 1 1 1 Putative oxalocrotonate tautomerase enzyme Tautomerase PF01361.21 EXF77807.1 - 0.015 15.2 0.0 0.029 14.3 0.0 1.4 1 0 0 1 1 1 0 Tautomerase enzyme DASH_Spc34 PF08657.10 EXF77807.1 - 0.034 14.0 0.0 0.057 13.2 0.0 1.5 2 0 0 2 2 2 0 DASH complex subunit Spc34 adh_short PF00106.25 EXF77808.1 - 4.7e-44 150.2 0.1 6.2e-44 149.8 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF77808.1 - 2e-42 145.3 0.0 2.6e-42 145.0 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF77808.1 - 4.1e-11 43.1 0.1 6.7e-11 42.4 0.1 1.2 1 0 0 1 1 1 1 KR domain GDP_Man_Dehyd PF16363.5 EXF77808.1 - 0.0013 18.2 0.0 0.0024 17.3 0.0 1.4 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 EXF77808.1 - 0.0034 16.6 0.0 0.0036 16.5 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.21 EXF77808.1 - 0.0044 16.5 0.1 0.0076 15.7 0.1 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EXF77808.1 - 0.0093 15.9 0.0 0.017 15.0 0.0 1.5 1 1 0 1 1 1 1 NAD(P)H-binding Cas9_PI PF16595.5 EXF77808.1 - 0.085 12.7 0.0 0.12 12.3 0.0 1.1 1 0 0 1 1 1 0 PAM-interacting domain of CRISPR-associated endonuclease Cas9 HSP70 PF00012.20 EXF77809.1 - 1.1e-57 195.6 11.0 2.4e-55 187.9 0.3 3.4 2 1 2 4 4 4 2 Hsp70 protein FAM104 PF15434.6 EXF77809.1 - 0.0059 17.2 0.2 0.0059 17.2 0.2 3.2 3 0 0 3 3 3 1 Family 104 MreB_Mbl PF06723.13 EXF77809.1 - 0.039 12.8 0.0 0.094 11.5 0.0 1.6 1 0 0 1 1 1 0 MreB/Mbl protein Lyase_8_N PF08124.11 EXF77809.1 - 0.1 11.5 0.7 0.35 9.7 0.7 1.8 1 0 0 1 1 1 0 Polysaccharide lyase family 8, N terminal alpha-helical domain Phage_TAC_12 PF12363.8 EXF77809.1 - 0.33 11.4 4.5 3.1 8.2 0.2 3.4 3 0 0 3 3 3 0 Phage tail assembly chaperone protein, TAC Syntaxin-6_N PF09177.11 EXF77809.1 - 1.2 9.8 7.4 13 6.4 4.2 4.2 3 1 0 3 3 3 0 Syntaxin 6, N-terminal DUF3484 PF11983.8 EXF77809.1 - 2 9.6 0.0 2 9.6 0.0 3.7 3 0 0 3 3 3 0 Membrane-attachment and polymerisation-promoting switch Mucin PF01456.17 EXF77809.1 - 2.2 8.2 22.8 1.8 8.5 8.5 3.2 3 0 0 3 3 3 0 Mucin-like glycoprotein Med9 PF07544.13 EXF77809.1 - 7.8 6.7 12.5 25 5.0 0.1 4.5 4 0 0 4 4 4 0 RNA polymerase II transcription mediator complex subunit 9 Asp PF00026.23 EXF77810.1 - 1.1e-28 100.6 0.0 1.5e-28 100.2 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EXF77810.1 - 1.5e-06 28.6 0.0 0.0085 16.3 0.0 3.3 2 2 0 2 2 2 1 Xylanase inhibitor N-terminal DASH_Spc34 PF08657.10 EXF77811.1 - 0.013 15.4 0.9 0.015 15.1 0.9 1.2 1 0 0 1 1 1 0 DASH complex subunit Spc34 DivIVA PF05103.13 EXF77811.1 - 0.023 14.8 2.5 0.032 14.3 2.5 1.1 1 0 0 1 1 1 0 DivIVA protein FliD_N PF02465.18 EXF77811.1 - 0.024 15.3 0.3 0.031 14.9 0.3 1.3 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus V_ATPase_I PF01496.19 EXF77811.1 - 0.053 11.4 0.8 0.057 11.3 0.8 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family SlyX PF04102.12 EXF77811.1 - 0.082 13.5 1.8 0.082 13.5 1.8 1.8 2 0 0 2 2 2 0 SlyX T3SSipB PF16535.5 EXF77811.1 - 0.092 13.2 4.2 0.12 12.9 4.2 1.1 1 0 0 1 1 1 0 Type III cell invasion protein SipB HeLo PF14479.6 EXF77811.1 - 0.098 12.5 1.0 0.12 12.2 1.0 1.1 1 0 0 1 1 1 0 Prion-inhibition and propagation XhlA PF10779.9 EXF77811.1 - 1.5 9.1 3.5 2.7 8.3 3.5 1.4 1 0 0 1 1 1 0 Haemolysin XhlA Ribosomal_S25 PF03297.15 EXF77812.1 - 1.2e-30 105.7 2.4 1.9e-30 105.0 1.5 1.7 2 0 0 2 2 2 1 S25 ribosomal protein HTH_24 PF13412.6 EXF77812.1 - 0.024 14.2 1.1 0.033 13.8 0.2 1.7 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding MarR_2 PF12802.7 EXF77812.1 - 0.033 14.1 0.0 0.092 12.7 0.0 1.7 2 0 0 2 2 2 0 MarR family HTH_DeoR PF08220.12 EXF77812.1 - 0.13 12.0 0.0 0.25 11.1 0.0 1.4 1 0 0 1 1 1 0 DeoR-like helix-turn-helix domain Ribosomal_S7 PF00177.21 EXF77813.1 - 1.1e-37 129.0 1.6 1.4e-37 128.7 1.6 1.1 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e Acetyltransf_1 PF00583.25 EXF77814.1 - 0.00013 22.2 0.1 0.0015 18.7 0.1 2.5 2 1 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EXF77814.1 - 0.00053 19.9 0.0 1 9.3 0.0 2.3 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_5 PF13444.6 EXF77814.1 - 0.0015 19.2 0.1 0.59 10.9 0.0 3.1 2 1 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EXF77814.1 - 0.013 15.9 0.0 0.045 14.2 0.0 1.8 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain HMA PF00403.26 EXF77815.1 - 7.9e-17 61.5 0.4 1.2e-16 60.9 0.4 1.3 1 0 0 1 1 1 1 Heavy-metal-associated domain Tcf25 PF04910.14 EXF77816.1 - 6.9e-61 206.3 0.8 1.3e-60 205.4 0.0 1.8 2 0 0 2 2 2 1 Transcriptional repressor TCF25 CENP-X PF09415.10 EXF77816.1 - 0.11 12.8 0.3 0.37 11.1 0.3 1.9 1 0 0 1 1 1 0 CENP-S associating Centromere protein X RNA_polI_A34 PF08208.11 EXF77816.1 - 2.1 8.4 18.4 4.4 7.3 18.4 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 LSM14 PF12701.7 EXF77817.1 - 4.5e-32 110.0 0.1 6.7e-32 109.4 0.1 1.3 1 0 0 1 1 1 1 Scd6-like Sm domain FDF PF09532.10 EXF77817.1 - 6.3e-23 81.6 0.5 1.4e-22 80.5 0.5 1.6 1 0 0 1 1 1 1 FDF domain SM-ATX PF14438.6 EXF77817.1 - 1.4e-07 31.5 0.0 2.6e-07 30.7 0.0 1.5 1 0 0 1 1 1 1 Ataxin 2 SM domain Steroid_dh PF02544.16 EXF77819.1 - 1.1e-32 113.0 0.6 1.6e-32 112.6 0.6 1.2 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.12 EXF77819.1 - 7.3e-05 22.4 1.3 0.00026 20.6 0.5 1.9 1 1 1 2 2 2 1 Protein of unknown function (DUF1295) PEMT PF04191.13 EXF77819.1 - 0.042 14.2 0.2 0.27 11.6 0.1 2.1 2 0 0 2 2 2 0 Phospholipid methyltransferase GCN5L1 PF06320.13 EXF77820.1 - 9.3e-19 67.7 0.2 9.3e-19 67.7 0.2 1.9 2 0 0 2 2 2 1 GCN5-like protein 1 (GCN5L1) SUIM_assoc PF16619.5 EXF77820.1 - 0.081 13.0 0.1 0.081 13.0 0.1 3.4 3 1 1 4 4 4 0 Unstructured region C-term to UIM in Ataxin3 FeoB_associated PF12669.7 EXF77820.1 - 0.23 11.9 3.6 0.45 11.0 3.6 1.4 1 0 0 1 1 1 0 FeoB-associated Cys-rich membrane protein Ndc1_Nup PF09531.10 EXF77820.1 - 0.86 8.2 10.2 1.4 7.6 10.2 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF1993 PF09351.10 EXF77821.1 - 3.5e-46 157.3 0.0 5.2e-46 156.7 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1993) DinB PF05163.12 EXF77821.1 - 0.065 13.2 0.0 0.1 12.5 0.0 1.3 1 0 0 1 1 1 0 DinB family SOG2 PF10428.9 EXF77822.1 - 6.7e-79 266.4 0.0 5.8e-53 180.8 0.0 3.9 4 1 1 5 5 5 2 RAM signalling pathway protein LRR_8 PF13855.6 EXF77822.1 - 3.2e-17 62.0 0.6 9.7e-09 34.9 0.1 2.6 2 0 0 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 EXF77822.1 - 4.2e-14 52.4 2.2 8.5e-06 26.0 0.2 3.8 2 1 1 3 3 3 3 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EXF77822.1 - 0.0024 17.8 3.6 1.7 8.9 0.1 4.2 3 0 0 3 3 3 2 Leucine Rich repeat LRR_1 PF00560.33 EXF77822.1 - 0.0044 17.4 2.6 20 6.2 0.0 4.7 4 0 0 4 4 4 1 Leucine Rich Repeat DUF2408 PF10303.9 EXF77822.1 - 0.0074 16.9 0.1 0.068 13.7 0.0 2.4 2 1 0 2 2 2 1 Protein of unknown function (DUF2408) Helicase_C PF00271.31 EXF77823.1 - 1.7e-17 63.8 0.0 4.4e-15 56.0 0.0 2.6 2 0 0 2 2 2 2 Helicase conserved C-terminal domain DEAD PF00270.29 EXF77823.1 - 5.6e-16 58.8 0.0 1.1e-15 57.8 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase RecQ_Zn_bind PF16124.5 EXF77823.1 - 8.7e-14 52.0 1.6 2.5e-13 50.5 1.6 1.8 1 0 0 1 1 1 1 RecQ zinc-binding Pyr_redox_2 PF07992.14 EXF77824.1 - 2.6e-61 207.4 0.5 4.2e-61 206.8 0.5 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 EXF77824.1 - 2.9e-33 114.4 0.5 1.3e-32 112.3 0.4 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 EXF77824.1 - 1.8e-19 70.1 1.5 9e-19 67.8 0.0 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EXF77824.1 - 3.5e-13 49.5 0.1 4.9e-13 49.0 0.1 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EXF77824.1 - 1.7e-06 27.4 0.1 0.00014 21.1 0.0 2.3 2 1 1 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) HI0933_like PF03486.14 EXF77824.1 - 0.00093 18.0 4.3 1.9 7.1 0.0 3.1 2 1 1 3 3 3 3 HI0933-like protein FAD_oxidored PF12831.7 EXF77824.1 - 0.0014 18.1 0.1 0.015 14.7 0.0 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase GIDA PF01134.22 EXF77824.1 - 0.086 11.9 1.4 0.13 11.3 0.1 2.0 2 1 1 3 3 3 0 Glucose inhibited division protein A FAD_binding_2 PF00890.24 EXF77824.1 - 0.65 9.0 4.2 6.8 5.6 2.9 2.3 2 0 0 2 2 2 0 FAD binding domain MID_MedPIWI PF18296.1 EXF77825.1 - 0.094 12.5 0.1 0.11 12.3 0.1 1.1 1 0 0 1 1 1 0 MID domain of medPIWI MSP1_C PF07462.11 EXF77825.1 - 4.2 6.0 3.7 4.9 5.7 3.7 1.0 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus Ribosomal_S8e PF01201.22 EXF77827.1 - 1.9e-55 186.8 2.0 2.6e-55 186.3 2.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S8e RabGAP-TBC PF00566.18 EXF77828.1 - 1.7e-50 171.7 1.9 3.2e-48 164.2 1.9 2.6 1 1 0 1 1 1 1 Rab-GTPase-TBC domain Cnn_1N PF07989.11 EXF77828.1 - 0.00057 20.0 3.9 0.00057 20.0 3.9 3.5 3 1 1 4 4 4 2 Centrosomin N-terminal motif 1 HALZ PF02183.18 EXF77828.1 - 0.0055 16.9 13.5 0.037 14.2 0.8 3.5 3 0 0 3 3 3 2 Homeobox associated leucine zipper Jnk-SapK_ap_N PF09744.9 EXF77828.1 - 0.0073 16.5 20.3 0.0073 16.5 20.3 3.2 2 1 1 3 3 3 1 JNK_SAPK-associated protein-1 KASH_CCD PF14662.6 EXF77828.1 - 0.043 13.7 26.0 0.11 12.3 26.0 1.8 1 1 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH FlaC_arch PF05377.11 EXF77828.1 - 0.37 11.2 12.6 1.1 9.7 2.3 3.4 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) Cep57_MT_bd PF06657.13 EXF77828.1 - 1.6 9.3 11.8 0.79 10.2 3.3 2.8 1 1 1 2 2 2 0 Centrosome microtubule-binding domain of Cep57 ADIP PF11559.8 EXF77828.1 - 2.1 8.4 31.5 1.2 9.2 8.3 3.5 2 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding bZIP_1 PF00170.21 EXF77828.1 - 9.2 6.4 24.2 1.9 8.7 3.4 4.0 3 1 0 3 3 3 0 bZIP transcription factor DUF913 PF06025.12 EXF77830.1 - 6.5e-133 443.2 0.0 6.5e-133 443.2 0.0 8.0 6 3 1 7 7 7 1 Domain of Unknown Function (DUF913) DUF908 PF06012.12 EXF77830.1 - 2.9e-119 398.7 2.8 2.9e-119 398.7 2.8 4.0 6 0 0 6 6 6 1 Domain of Unknown Function (DUF908) HECT PF00632.25 EXF77830.1 - 1.3e-93 313.8 0.1 2.8e-93 312.8 0.0 1.6 2 0 0 2 2 2 1 HECT-domain (ubiquitin-transferase) UBM PF14377.6 EXF77830.1 - 1.6e-25 87.7 19.0 2.4e-08 33.2 3.1 4.0 3 0 0 3 3 3 3 Ubiquitin binding region Pribosyl_synth PF14572.6 EXF77831.1 - 1.2e-42 146.0 0.5 6.5e-37 127.3 0.4 2.5 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.6 EXF77831.1 - 9.9e-35 119.0 0.0 4e-34 117.0 0.0 1.9 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.27 EXF77831.1 - 3.5e-16 59.1 1.2 5.8e-16 58.4 0.4 1.7 2 0 0 2 2 2 1 Phosphoribosyl transferase domain UPRTase PF14681.6 EXF77831.1 - 0.016 14.6 0.1 0.026 14.0 0.1 1.3 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase Ribosomal_S6e PF01092.19 EXF77832.1 - 3e-59 198.5 0.0 5.9e-59 197.5 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein S6e Atg14 PF10186.9 EXF77832.1 - 3.4 6.7 8.6 4.4 6.3 8.6 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Ctf8 PF09696.10 EXF77833.1 - 6e-41 140.1 0.0 9.1e-41 139.5 0.0 1.3 1 0 0 1 1 1 1 Ctf8 Glyco_hydro_10 PF00331.20 EXF77834.1 - 1.6e-88 296.9 0.0 1.9e-88 296.7 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 10 AP_endonuc_2 PF01261.24 EXF77834.1 - 0.067 12.6 0.1 0.42 10.0 0.0 2.2 2 1 0 2 2 2 0 Xylose isomerase-like TIM barrel Fungal_trans_2 PF11951.8 EXF77835.1 - 0.00012 21.0 0.2 0.15 10.8 0.1 2.1 2 0 0 2 2 2 2 Fungal specific transcription factor domain Diphthamide_syn PF01866.17 EXF77836.1 - 6.8e-117 390.2 0.0 8.3e-117 389.9 0.0 1.1 1 0 0 1 1 1 1 Putative diphthamide synthesis protein CN_hydrolase PF00795.22 EXF77837.1 - 2.6e-42 145.0 0.2 1.1e-41 142.9 0.2 1.8 1 1 0 1 1 1 1 Carbon-nitrogen hydrolase AA_permease_2 PF13520.6 EXF77839.1 - 6.5e-90 302.0 31.4 8.1e-90 301.7 31.4 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EXF77839.1 - 1.6e-20 73.2 28.1 2.4e-20 72.6 28.1 1.2 1 0 0 1 1 1 1 Amino acid permease SirB PF04247.12 EXF77839.1 - 0.068 13.3 2.0 0.16 12.1 0.1 2.6 2 0 0 2 2 2 0 Invasion gene expression up-regulator, SirB MFS_1 PF07690.16 EXF77840.1 - 1.9e-14 53.4 50.5 1.9e-14 53.4 50.5 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily Asparaginase_II PF06089.12 EXF77841.1 - 3.8e-118 394.2 1.1 4.3e-118 394.0 1.1 1.0 1 0 0 1 1 1 1 L-asparaginase II GFA PF04828.14 EXF77842.1 - 4.8e-22 78.1 0.6 6.9e-22 77.6 0.6 1.2 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme Peptidase_C32 PF05411.12 EXF77842.1 - 0.098 12.6 0.0 5.4 6.9 0.0 2.1 1 1 1 2 2 2 0 Equine arteritis virus putative proteinase NOB1_Zn_bind PF08772.11 EXF77842.1 - 0.25 11.6 3.7 3 8.1 0.0 2.3 2 0 0 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like Fungal_trans_2 PF11951.8 EXF77843.1 - 0.047 12.5 0.1 0.074 11.8 0.1 1.3 1 0 0 1 1 1 0 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF77844.1 - 1.6e-07 31.3 10.6 2.5e-07 30.7 10.6 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EXF77844.1 - 0.091 11.8 0.2 0.16 11.0 0.2 1.4 1 0 0 1 1 1 0 Fungal specific transcription factor domain fn3_4 PF16794.5 EXF77844.1 - 0.11 12.5 0.1 0.28 11.1 0.0 1.7 2 0 0 2 2 2 0 Fibronectin-III type domain Rep_fac-A_C PF08646.10 EXF77844.1 - 1.2 8.9 3.8 3.1 7.6 3.8 1.6 1 0 0 1 1 1 0 Replication factor-A C terminal domain 2OG-FeII_Oxy_3 PF13640.6 EXF77846.1 - 2.1e-09 38.2 0.1 3.3e-09 37.5 0.1 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Acetyltransf_10 PF13673.7 EXF77847.1 - 2.1e-11 43.9 0.0 3.2e-11 43.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EXF77847.1 - 1.3e-09 38.3 0.0 2.5e-09 37.4 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EXF77847.1 - 1.3e-09 38.3 0.1 2.7e-09 37.3 0.1 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 EXF77847.1 - 0.00018 21.4 0.0 0.00031 20.6 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.6 EXF77847.1 - 0.0045 17.1 0.0 0.0076 16.4 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_9 PF13527.7 EXF77847.1 - 0.0049 16.9 0.0 0.013 15.6 0.0 1.6 1 1 1 2 2 2 1 Acetyltransferase (GNAT) domain DHDPS PF00701.22 EXF77848.1 - 4.6e-39 133.9 0.0 6e-39 133.5 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family DUF3716 PF12511.8 EXF77849.1 - 1.1e-08 34.9 0.8 2.3e-08 33.9 0.8 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3716) ApbA PF02558.16 EXF77850.1 - 1.9e-32 112.0 0.1 2.5e-32 111.6 0.1 1.2 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA ApbA_C PF08546.11 EXF77850.1 - 5.3e-30 104.2 0.0 7.9e-30 103.6 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal MFS_1 PF07690.16 EXF77851.1 - 3.1e-37 128.3 31.7 3.1e-37 128.3 31.7 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF77851.1 - 2.2e-06 26.8 21.3 1.4e-05 24.2 21.0 2.0 1 1 0 1 1 1 1 Sugar (and other) transporter SGL PF08450.12 EXF77852.1 - 1.9e-12 47.3 0.1 3.7e-12 46.4 0.1 1.5 1 1 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Str_synth PF03088.16 EXF77852.1 - 0.0011 19.0 0.0 3 8.0 0.0 4.1 4 1 0 4 4 4 2 Strictosidine synthase MFS_1 PF07690.16 EXF77853.1 - 1.3e-45 155.9 28.7 1.3e-45 155.9 28.7 1.3 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF77853.1 - 1.5e-14 53.7 14.9 1.5e-14 53.7 14.9 2.1 2 1 0 2 2 2 1 Sugar (and other) transporter MFS_4 PF06779.14 EXF77853.1 - 1e-05 25.0 3.7 1e-05 25.0 3.7 2.9 3 0 0 3 3 3 1 Uncharacterised MFS-type transporter YbfB OATP PF03137.20 EXF77853.1 - 0.27 9.5 15.1 0.0054 15.1 6.9 2.3 2 1 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family DUF5353 PF17304.2 EXF77853.1 - 0.36 10.6 2.8 5 7.0 0.9 2.9 2 0 0 2 2 2 0 Family of unknown function (DUF5353) MFS_3 PF05977.13 EXF77853.1 - 0.94 7.8 7.8 0.075 11.4 2.7 1.6 2 0 0 2 2 2 0 Transmembrane secretion effector Utp14 PF04615.13 EXF77854.1 - 0.035 12.7 10.7 0.046 12.3 10.7 1.1 1 0 0 1 1 1 0 Utp14 protein CFEM PF05730.11 EXF77855.1 - 1.1e-09 38.2 8.7 2.1e-09 37.3 8.7 1.5 1 0 0 1 1 1 1 CFEM domain Defensin_2 PF01097.18 EXF77855.1 - 0.88 9.6 2.9 2.8 8.0 2.9 1.9 1 0 0 1 1 1 0 Arthropod defensin adh_short PF00106.25 EXF77856.1 - 7.7e-19 67.9 0.0 4.9e-15 55.5 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EXF77856.1 - 1.5e-13 50.9 0.1 2e-12 47.2 0.1 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.6 EXF77856.1 - 1.9e-05 24.6 0.3 2.7e-05 24.1 0.3 1.4 1 1 0 1 1 1 1 NAD(P)H-binding KR PF08659.10 EXF77856.1 - 2.3e-05 24.4 0.3 3.9e-05 23.6 0.3 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EXF77856.1 - 0.0001 21.8 0.0 0.00014 21.5 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 EXF77856.1 - 0.0023 17.5 0.3 0.0036 16.9 0.3 1.3 1 0 0 1 1 1 1 NmrA-like family Glyco_transf_4 PF13439.6 EXF77856.1 - 0.024 14.7 0.0 0.039 13.9 0.0 1.4 1 0 0 1 1 1 0 Glycosyltransferase Family 4 Sugar_tr PF00083.24 EXF77857.1 - 4.5e-43 147.7 17.5 6.2e-43 147.3 17.5 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF77857.1 - 2.5e-32 112.2 28.3 4.2e-26 91.7 12.2 2.2 1 1 0 2 2 2 2 Major Facilitator Superfamily PCP_red PF08369.10 EXF77857.1 - 0.19 12.0 0.2 0.49 10.7 0.2 1.7 1 0 0 1 1 1 0 Proto-chlorophyllide reductase 57 kD subunit Peptidase_S8 PF00082.22 EXF77858.1 - 6.8e-18 64.9 0.1 1.5e-17 63.8 0.0 1.5 2 0 0 2 2 2 1 Subtilase family Peptidase_S8 PF00082.22 EXF77859.1 - 3.7e-14 52.7 0.1 6.1e-14 52.0 0.1 1.3 1 0 0 1 1 1 1 Subtilase family fn3_5 PF06280.12 EXF77859.1 - 6.6e-06 26.8 0.1 4.1e-05 24.2 0.0 2.3 2 1 0 2 2 2 1 Fn3-like domain PA PF02225.22 EXF77859.1 - 0.0042 17.1 0.0 0.011 15.7 0.0 1.7 1 0 0 1 1 1 1 PA domain DUF4232 PF14016.6 EXF77859.1 - 0.042 14.0 0.1 0.51 10.5 0.1 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF4232) Cupin_2 PF07883.11 EXF77860.1 - 3.9e-10 39.3 0.7 6.3e-10 38.6 0.7 1.4 1 0 0 1 1 1 1 Cupin domain Cupin_7 PF12973.7 EXF77860.1 - 4.6e-05 23.3 0.0 6.9e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 ChrR Cupin-like domain Cupin_1 PF00190.22 EXF77860.1 - 0.00029 20.5 0.1 0.00034 20.2 0.1 1.1 1 0 0 1 1 1 1 Cupin AraC_binding PF02311.19 EXF77860.1 - 0.00036 20.5 0.3 0.00045 20.1 0.3 1.1 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_3 PF05899.12 EXF77860.1 - 0.00049 19.7 0.1 0.00067 19.3 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF861) Cupin_6 PF12852.7 EXF77860.1 - 0.00086 19.1 0.3 0.0011 18.8 0.3 1.1 1 0 0 1 1 1 1 Cupin Amidohydro_1 PF01979.20 EXF77861.1 - 2.5e-31 109.3 0.0 4.7e-31 108.4 0.0 1.4 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EXF77861.1 - 7.1e-12 45.5 1.1 1.7e-08 34.4 0.1 2.3 2 0 0 2 2 2 2 Amidohydrolase family Acetyltransf_1 PF00583.25 EXF77862.1 - 3.1e-14 53.2 0.0 5.2e-14 52.5 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_3 PF13302.7 EXF77862.1 - 2.7e-13 50.8 0.0 4e-13 50.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EXF77862.1 - 6.2e-10 39.4 0.0 9.8e-10 38.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 EXF77862.1 - 2.2e-05 24.2 0.0 3.3e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EXF77862.1 - 2.8e-05 24.0 0.1 8.4e-05 22.5 0.0 1.9 2 0 0 2 2 2 1 FR47-like protein Acetyltransf_10 PF13673.7 EXF77862.1 - 4e-05 23.5 0.0 8.8e-05 22.5 0.0 1.5 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 EXF77862.1 - 0.00071 19.8 0.0 0.00098 19.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Ank_2 PF12796.7 EXF77864.1 - 3.3e-20 72.5 0.0 4.4e-09 36.8 0.0 3.7 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EXF77864.1 - 1e-19 70.3 0.4 7.6e-06 26.1 0.0 5.3 3 2 3 6 6 6 5 Ankyrin repeats (many copies) Ank_4 PF13637.6 EXF77864.1 - 5e-18 65.2 0.1 1.4e-06 28.7 0.0 5.0 1 1 5 6 6 6 3 Ankyrin repeats (many copies) Ank PF00023.30 EXF77864.1 - 6.8e-18 64.2 2.1 0.0015 18.9 0.1 5.4 4 1 1 5 5 5 5 Ankyrin repeat Ank_3 PF13606.6 EXF77864.1 - 1.2e-17 62.1 0.0 0.0042 17.5 0.0 6.3 6 0 0 6 6 6 5 Ankyrin repeat HET PF06985.11 EXF77867.1 - 3.1e-08 34.1 3.0 1.6e-05 25.3 0.2 2.3 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) YsaB PF13983.6 EXF77867.1 - 0.14 12.5 0.0 0.26 11.6 0.0 1.4 1 0 0 1 1 1 0 YsaB-like lipoprotein Cu_bind_like PF02298.17 EXF77868.1 - 0.00025 21.0 0.2 0.00076 19.4 0.2 1.7 1 1 0 1 1 1 1 Plastocyanin-like domain Copper-bind PF00127.20 EXF77868.1 - 0.042 14.3 0.2 0.11 12.9 0.2 1.6 1 1 0 1 1 1 0 Copper binding proteins, plastocyanin/azurin family PepSY_2 PF13670.6 EXF77868.1 - 0.37 10.8 0.0 0.37 10.8 0.0 1.9 2 1 0 2 2 2 0 Peptidase propeptide and YPEB domain AF-4 PF05110.13 EXF77868.1 - 3.8 5.5 5.8 5.7 4.9 5.8 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein PKD_channel PF08016.12 EXF77869.1 - 9.6e-07 27.8 16.0 6e-05 21.9 15.9 2.5 1 1 0 1 1 1 1 Polycystin cation channel Ion_trans PF00520.31 EXF77869.1 - 6e-05 22.4 28.7 0.00012 21.4 21.8 2.6 2 1 0 2 2 2 1 Ion transport protein AP3D1 PF06375.11 EXF77869.1 - 0.63 10.3 6.8 1.1 9.5 6.8 1.3 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 FSH1 PF03959.13 EXF77870.1 - 4.8e-32 111.3 0.0 6.1e-32 111.0 0.0 1.1 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_6 PF12697.7 EXF77870.1 - 0.00038 21.1 0.8 0.0019 18.8 0.2 1.8 1 1 1 2 2 2 1 Alpha/beta hydrolase family F-box-like PF12937.7 EXF77871.1 - 0.059 13.3 0.4 0.15 11.9 0.4 1.8 1 0 0 1 1 1 0 F-box-like SSF PF00474.17 EXF77872.1 - 9.1e-17 61.0 27.7 1.3e-16 60.5 27.7 1.2 1 0 0 1 1 1 1 Sodium:solute symporter family FtsJ PF01728.19 EXF77872.1 - 1.4e-12 48.0 0.0 2.5e-12 47.3 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase Tma16 PF11176.8 EXF77872.1 - 0.061 13.2 0.1 0.13 12.2 0.1 1.4 1 0 0 1 1 1 0 Translation machinery-associated protein 16 Bac_luciferase PF00296.20 EXF77873.1 - 6.7e-55 186.7 0.1 1.1e-54 186.0 0.1 1.2 1 0 0 1 1 1 1 Luciferase-like monooxygenase Lactamase_B PF00753.27 EXF77874.1 - 6.1e-05 23.1 2.0 0.00014 21.9 2.0 1.6 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily peroxidase PF00141.23 EXF77875.1 - 1.3e-29 103.5 0.0 2.2e-29 102.8 0.0 1.3 1 0 0 1 1 1 1 Peroxidase AA_permease_2 PF13520.6 EXF77876.1 - 6.4e-58 196.6 47.4 8.4e-58 196.2 47.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EXF77876.1 - 1.2e-16 60.3 36.8 1.8e-16 59.8 36.8 1.2 1 0 0 1 1 1 1 Amino acid permease DUF2456 PF10445.9 EXF77876.1 - 1.2 9.2 7.9 4.7 7.4 0.1 3.7 4 0 0 4 4 4 0 Protein of unknown function (DUF2456) 60KD_IMP PF02096.20 EXF77876.1 - 5.7 6.8 10.6 0.54 10.1 3.7 2.3 2 0 0 2 2 2 0 60Kd inner membrane protein DUF1772 PF08592.11 EXF77877.1 - 1.3e-09 38.5 2.7 1.6e-09 38.2 2.2 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF1772) AAA PF00004.29 EXF77878.1 - 2e-15 57.4 0.0 5.9e-15 55.9 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Macoilin PF09726.9 EXF77878.1 - 5.3e-05 22.0 17.7 8.4e-05 21.3 17.7 1.3 1 0 0 1 1 1 1 Macoilin family AAA_22 PF13401.6 EXF77878.1 - 0.0024 18.1 1.9 0.11 12.7 0.1 2.8 1 1 1 2 2 2 1 AAA domain AAA_5 PF07728.14 EXF77878.1 - 0.0037 17.2 0.0 0.01 15.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_30 PF13604.6 EXF77878.1 - 0.041 13.6 0.0 0.1 12.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EXF77878.1 - 0.06 13.9 0.0 0.31 11.6 0.0 2.3 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EXF77878.1 - 0.067 13.6 0.5 0.31 11.4 0.5 2.2 1 1 0 1 1 1 0 AAA ATPase domain AAA_11 PF13086.6 EXF77878.1 - 0.11 12.2 0.0 0.11 12.2 0.0 3.9 4 0 0 4 4 4 0 AAA domain AAA_33 PF13671.6 EXF77878.1 - 0.13 12.5 0.0 0.32 11.1 0.0 1.8 1 0 0 1 1 1 0 AAA domain Egh16-like PF11327.8 EXF77879.1 - 9.4e-49 166.3 9.2 1.1e-48 166.1 9.2 1.1 1 0 0 1 1 1 1 Egh16-like virulence factor HemeBinding_Shp PF11545.8 EXF77879.1 - 0.016 15.2 0.3 0.036 14.1 0.3 1.5 1 0 0 1 1 1 0 Cell surface heme-binding protein Shp DUF2273 PF10031.9 EXF77880.1 - 5.2 7.2 13.5 0.12 12.5 4.6 2.5 1 1 1 2 2 2 0 Small integral membrane protein (DUF2273) Acetyltransf_1 PF00583.25 EXF77882.1 - 7.2e-17 61.7 0.0 9e-17 61.4 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EXF77882.1 - 7.7e-11 42.3 0.0 1.2e-10 41.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EXF77882.1 - 1.7e-10 40.9 0.0 2.3e-10 40.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 EXF77882.1 - 5.5e-08 33.6 0.0 6.5e-08 33.3 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EXF77882.1 - 8e-05 22.7 0.0 0.0001 22.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EXF77882.1 - 0.00011 22.3 0.0 0.00021 21.4 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_4 PF13420.7 EXF77882.1 - 0.00032 20.9 0.0 0.00047 20.3 0.0 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EXF77882.1 - 0.00095 19.1 0.0 0.0015 18.5 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_13 PF13880.6 EXF77882.1 - 0.044 13.8 0.0 0.084 12.9 0.0 1.4 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase GNAT_acetyltr_2 PF13718.6 EXF77882.1 - 0.085 12.3 0.1 1 8.7 0.0 2.0 2 0 0 2 2 2 0 GNAT acetyltransferase 2 Acetyltransf_5 PF13444.6 EXF77882.1 - 0.086 13.6 0.0 0.17 12.6 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain FAD_binding_4 PF01565.23 EXF77883.1 - 2.5e-26 92.1 1.2 2.5e-26 92.1 1.2 2.0 2 0 0 2 2 2 1 FAD binding domain BBE PF08031.12 EXF77883.1 - 0.017 15.2 0.1 0.034 14.3 0.1 1.5 1 0 0 1 1 1 0 Berberine and berberine like Ntox27 PF15531.6 EXF77883.1 - 0.049 13.5 0.1 0.22 11.5 0.0 2.0 2 0 0 2 2 2 0 Bacterial toxin 27 DUF1996 PF09362.10 EXF77884.1 - 1.2e-44 153.1 0.3 1.6e-44 152.7 0.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1996) WSC PF01822.19 EXF77885.1 - 5.6e-13 48.9 4.9 5.6e-13 48.9 4.9 4.0 3 1 1 4 4 4 1 WSC domain YhfC PF10086.9 EXF77886.1 - 0.012 15.0 0.2 0.018 14.4 0.2 1.3 1 0 0 1 1 1 0 YhfC intramembrane metalloprotease Pico_P1A PF02226.16 EXF77886.1 - 0.23 11.5 0.4 0.74 9.9 0.1 1.8 2 0 0 2 2 2 0 Picornavirus coat protein (VP4) HET PF06985.11 EXF77887.1 - 5.8e-34 117.5 0.8 2.2e-33 115.7 0.0 2.2 2 1 0 2 2 2 1 Heterokaryon incompatibility protein (HET) CMV_1a PF12467.8 EXF77887.1 - 0.16 12.3 0.0 0.31 11.4 0.0 1.4 1 0 0 1 1 1 0 Cucumber mosaic virus 1a protein family UDPGT PF00201.18 EXF77888.1 - 3.2e-09 36.1 0.0 5.2e-09 35.4 0.0 1.2 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Epimerase_2 PF02350.19 EXF77888.1 - 0.12 11.2 0.0 0.18 10.6 0.0 1.2 1 0 0 1 1 1 0 UDP-N-acetylglucosamine 2-epimerase Glyco_transf_28 PF03033.20 EXF77888.1 - 0.17 11.9 0.0 0.32 11.0 0.0 1.5 1 0 0 1 1 1 0 Glycosyltransferase family 28 N-terminal domain Metallopep PF12044.8 EXF77889.1 - 1.7e-132 442.1 0.0 2.2e-132 441.7 0.0 1.1 1 0 0 1 1 1 1 Putative peptidase family Reprolysin_3 PF13582.6 EXF77889.1 - 0.0026 18.3 0.1 0.0053 17.3 0.1 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 EXF77889.1 - 0.007 16.5 0.4 0.013 15.6 0.4 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12 Peptidase_M66 PF10462.9 EXF77889.1 - 0.027 13.4 0.7 0.046 12.7 0.7 1.2 1 0 0 1 1 1 0 Peptidase M66 Reprolysin_2 PF13574.6 EXF77889.1 - 0.053 13.4 0.4 0.099 12.5 0.4 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 EXF77889.1 - 0.12 12.0 0.2 0.21 11.2 0.2 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like TPR_2 PF07719.17 EXF77890.1 - 2.7e-10 39.5 2.9 0.0084 16.2 0.0 4.7 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 EXF77890.1 - 6.9e-07 28.8 0.0 0.012 15.4 0.0 4.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 EXF77890.1 - 2.5e-06 27.7 0.6 0.17 12.2 0.0 3.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 EXF77890.1 - 0.00082 19.4 0.0 3.6 8.0 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 EXF77890.1 - 0.0015 19.1 8.2 0.003 18.2 0.5 4.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 EXF77890.1 - 0.0026 17.4 0.0 2.6 7.8 0.0 4.2 4 1 1 5 5 5 1 TPR repeat TPR_9 PF13371.6 EXF77890.1 - 0.018 15.2 0.7 0.18 12.0 0.1 3.0 2 1 1 3 3 3 0 Tetratricopeptide repeat WXG100 PF06013.12 EXF77890.1 - 0.022 15.0 0.1 0.078 13.2 0.1 2.0 1 0 0 1 1 1 0 Proteins of 100 residues with WXG TPR_7 PF13176.6 EXF77890.1 - 0.044 13.8 0.3 6.5 7.0 0.0 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat SHNi-TPR PF10516.9 EXF77890.1 - 0.045 13.2 0.0 0.12 11.9 0.0 1.6 1 0 0 1 1 1 0 SHNi-TPR TPR_14 PF13428.6 EXF77890.1 - 0.15 13.0 15.8 0.21 12.5 0.1 5.8 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_6 PF13174.6 EXF77890.1 - 0.5 11.1 2.7 1.6e+02 3.2 0.0 4.3 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 EXF77890.1 - 0.84 10.2 4.6 8.8 6.9 0.1 3.8 4 1 1 5 5 4 0 Tetratricopeptide repeat GYF PF02213.16 EXF77891.1 - 8.6e-19 66.9 0.3 1.8e-18 65.9 0.3 1.6 1 0 0 1 1 1 1 GYF domain GYF_2 PF14237.6 EXF77891.1 - 0.0048 16.7 0.0 0.014 15.2 0.0 1.9 1 0 0 1 1 1 1 GYF domain 2 Med26 PF08711.11 EXF77892.1 - 0.049 13.7 0.0 0.1 12.6 0.0 1.6 1 0 0 1 1 1 0 TFIIS helical bundle-like domain DUF1304 PF06993.12 EXF77893.1 - 2.3e-43 146.7 1.8 2.6e-43 146.5 1.8 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1304) Dynamin_N PF00350.23 EXF77894.1 - 5.7e-18 65.5 2.3 6.1e-18 65.4 0.0 2.2 2 0 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.23 EXF77894.1 - 1.3e-05 25.2 0.0 0.00017 21.7 0.0 2.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 EXF77894.1 - 0.0003 21.2 0.6 0.0037 17.7 0.0 3.1 4 0 0 4 4 3 1 AAA ATPase domain NPV_P10 PF05531.12 EXF77894.1 - 0.00072 20.0 2.6 11 6.5 0.0 4.5 4 0 0 4 4 4 0 Nucleopolyhedrovirus P10 protein RsgA_GTPase PF03193.16 EXF77894.1 - 0.00077 19.4 0.0 0.0067 16.3 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase ABC_tran PF00005.27 EXF77894.1 - 0.0018 18.8 0.0 0.0018 18.8 0.0 2.8 2 1 0 2 2 1 1 ABC transporter DUF1043 PF06295.12 EXF77894.1 - 0.0083 16.1 3.0 2.4 8.2 0.4 3.1 1 1 1 2 2 2 1 Protein of unknown function (DUF1043) AAA_22 PF13401.6 EXF77894.1 - 0.0099 16.2 0.1 0.16 12.2 0.0 3.0 2 1 0 2 2 2 1 AAA domain APG6_N PF17675.1 EXF77894.1 - 0.011 16.2 12.4 0.28 11.7 3.8 3.6 3 0 0 3 3 3 0 Apg6 coiled-coil region ASD2 PF08687.11 EXF77894.1 - 0.027 14.0 10.1 0.098 12.2 8.3 2.3 2 0 0 2 2 2 0 Apx/Shroom domain ASD2 CENP-F_leu_zip PF10473.9 EXF77894.1 - 0.027 14.5 15.8 0.066 13.2 0.7 3.5 2 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Zeta_toxin PF06414.12 EXF77894.1 - 0.028 13.7 0.0 0.086 12.1 0.0 1.8 1 0 0 1 1 1 0 Zeta toxin L31 PF09784.9 EXF77894.1 - 0.029 14.8 1.3 0.12 12.8 0.2 2.7 3 0 0 3 3 1 0 Mitochondrial ribosomal protein L31 IIGP PF05049.13 EXF77894.1 - 0.037 13.1 0.0 0.078 12.0 0.0 1.5 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) AIG1 PF04548.16 EXF77894.1 - 0.059 12.7 2.3 0.17 11.2 0.0 2.6 3 0 0 3 3 3 0 AIG1 family BLOC1_2 PF10046.9 EXF77894.1 - 0.07 13.4 3.7 13 6.1 0.0 3.6 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DASH_Dad2 PF08654.10 EXF77894.1 - 0.27 11.7 7.2 3.1 8.3 0.2 3.9 2 1 1 3 3 3 0 DASH complex subunit Dad2 Fungal_TACC PF12709.7 EXF77894.1 - 0.37 11.3 6.8 1.3 9.5 0.4 3.0 2 0 0 2 2 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins YabA PF06156.13 EXF77894.1 - 0.41 11.3 4.0 18 6.0 0.8 3.7 3 0 0 3 3 2 0 Initiation control protein YabA GIT1_C PF12205.8 EXF77894.1 - 0.76 9.9 3.6 11 6.2 0.6 3.5 4 0 0 4 4 3 0 G protein-coupled receptor kinase-interacting protein 1 C term Plk4_PB2 PF18409.1 EXF77894.1 - 1.5 9.6 5.5 21 5.8 1.2 3.2 3 0 0 3 3 2 0 Polo-like Kinase 4 Polo Box 2 DUF4140 PF13600.6 EXF77894.1 - 1.8 9.0 7.8 10 6.6 0.3 3.7 3 0 0 3 3 3 0 N-terminal domain of unknown function (DUF4140) Spc24 PF08286.11 EXF77894.1 - 3 8.1 8.3 4.7 7.5 0.2 3.6 3 0 0 3 3 3 0 Spc24 subunit of Ndc80 UPF0242 PF06785.11 EXF77894.1 - 4.2 7.4 9.1 52 3.9 0.0 2.7 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF1664 PF07889.12 EXF77894.1 - 6.1 6.9 7.1 1.8 8.6 1.4 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) DUF3450 PF11932.8 EXF77894.1 - 7.1 5.9 10.2 4.6 6.5 5.3 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) LMBR1 PF04791.16 EXF77894.1 - 7.4 5.4 7.5 13 4.5 7.5 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein CCDC106 PF15794.5 EXF77894.1 - 7.5 6.2 15.5 3.3 7.4 12.4 2.0 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 SKG6 PF08693.10 EXF77895.1 - 0.058 12.8 2.0 0.058 12.8 2.0 1.6 2 0 0 2 2 2 0 Transmembrane alpha-helix domain Tugs PF17840.1 EXF77896.1 - 0.11 12.7 1.0 0.21 11.8 1.0 1.4 1 0 0 1 1 1 0 Tethering Ubl4a to BAGS domain Beta-lactamase PF00144.24 EXF77897.1 - 3.2e-50 171.3 1.1 4.1e-50 170.9 1.1 1.1 1 0 0 1 1 1 1 Beta-lactamase DUF3425 PF11905.8 EXF77898.1 - 1.4e-15 57.3 0.0 4e-15 55.9 0.0 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF3425) Mto2_bdg PF12808.7 EXF77898.1 - 2e-05 24.8 0.8 0.00021 21.5 1.7 2.0 2 0 0 2 2 2 1 Micro-tubular organiser Mto1 C-term Mto2-binding region SIKE PF05769.11 EXF77898.1 - 0.0054 16.7 0.7 0.0092 15.9 0.7 1.3 1 0 0 1 1 1 1 SIKE family DUF4763 PF15960.5 EXF77898.1 - 0.0076 15.6 1.2 0.014 14.7 1.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4763) CCDC144C PF14915.6 EXF77898.1 - 0.016 14.3 1.7 0.025 13.7 1.7 1.2 1 0 0 1 1 1 0 CCDC144C protein coiled-coil region YPEB PF14620.6 EXF77898.1 - 0.018 14.4 0.8 0.026 13.9 0.2 1.4 2 0 0 2 2 2 0 YpeB sporulation ZapB PF06005.12 EXF77898.1 - 0.023 15.1 3.4 0.041 14.3 3.4 1.4 1 0 0 1 1 1 0 Cell division protein ZapB Med21 PF11221.8 EXF77898.1 - 0.042 14.1 2.1 0.08 13.2 2.1 1.4 1 0 0 1 1 1 0 Subunit 21 of Mediator complex BicD PF09730.9 EXF77898.1 - 0.066 11.6 1.2 0.098 11.1 1.2 1.1 1 0 0 1 1 1 0 Microtubule-associated protein Bicaudal-D DUF1471 PF07338.13 EXF77898.1 - 0.073 13.0 0.0 0.2 11.7 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1471) DUF3450 PF11932.8 EXF77898.1 - 0.29 10.4 2.3 3.7 6.8 2.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) Beta_elim_lyase PF01212.21 EXF77899.1 - 3.4e-38 131.6 0.0 4.5e-38 131.2 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.21 EXF77899.1 - 7.9e-06 25.3 0.0 1e-05 24.9 0.0 1.2 1 1 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 EXF77899.1 - 0.00065 18.8 0.0 0.00086 18.4 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Toprim PF01751.22 EXF77899.1 - 0.11 12.7 0.0 0.3 11.3 0.0 1.7 1 1 0 1 1 1 0 Toprim domain AhpC-TSA_2 PF13911.6 EXF77900.1 - 5.1e-05 23.4 0.0 8e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme AhpC-TSA PF00578.21 EXF77900.1 - 0.00041 20.3 0.0 0.00048 20.0 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EXF77900.1 - 0.11 12.3 0.0 0.2 11.4 0.0 1.4 1 1 0 1 1 1 0 Redoxin ABC_tran PF00005.27 EXF77901.1 - 1.9e-47 161.2 0.2 1e-23 84.4 0.0 3.8 2 2 0 2 2 2 2 ABC transporter 4HB PF17947.1 EXF77901.1 - 1.2e-26 92.5 0.3 1.2e-26 92.5 0.3 2.1 2 0 0 2 2 1 1 Four helical bundle domain AAA_21 PF13304.6 EXF77901.1 - 7.8e-18 65.3 0.0 0.002 18.0 0.0 5.2 5 0 0 5 5 5 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EXF77901.1 - 5e-16 58.8 0.6 2.1e-05 24.1 0.1 4.1 2 2 1 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EXF77901.1 - 2.1e-09 38.2 5.6 0.0003 21.4 0.1 3.3 3 1 0 3 3 2 2 AAA domain RsgA_GTPase PF03193.16 EXF77901.1 - 9.8e-09 35.3 0.0 0.00012 22.0 0.0 2.8 2 0 0 2 2 2 2 RsgA GTPase AAA_29 PF13555.6 EXF77901.1 - 1.3e-08 34.4 0.1 0.0047 16.6 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 EXF77901.1 - 2.2e-07 30.9 0.0 0.0019 18.3 0.0 3.2 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_22 PF13401.6 EXF77901.1 - 8.9e-07 29.3 0.0 0.014 15.6 0.0 3.4 3 0 0 3 3 3 2 AAA domain AAA_28 PF13521.6 EXF77901.1 - 1.2e-06 28.8 0.0 0.017 15.4 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_15 PF13175.6 EXF77901.1 - 1.3e-06 28.5 0.7 0.073 12.8 0.0 4.1 5 0 0 5 5 4 2 AAA ATPase domain AAA_18 PF13238.6 EXF77901.1 - 7.4e-06 26.5 0.2 0.18 12.4 0.0 3.5 4 0 0 4 4 2 2 AAA domain AAA_16 PF13191.6 EXF77901.1 - 1.7e-05 25.3 0.1 0.23 11.8 0.0 3.7 4 0 0 4 4 3 2 AAA ATPase domain AAA PF00004.29 EXF77901.1 - 1.7e-05 25.2 0.0 0.42 11.0 0.0 4.2 4 0 0 4 4 3 1 ATPase family associated with various cellular activities (AAA) PduV-EutP PF10662.9 EXF77901.1 - 5.3e-05 23.0 0.1 0.053 13.3 0.0 2.9 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation Dynamin_N PF00350.23 EXF77901.1 - 5.4e-05 23.3 1.6 0.0022 18.0 0.0 3.1 4 0 0 4 4 2 1 Dynamin family AAA_33 PF13671.6 EXF77901.1 - 5.9e-05 23.3 0.0 0.53 10.4 0.0 3.1 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.22 EXF77901.1 - 7.6e-05 23.1 0.0 0.95 9.9 0.0 3.1 2 0 0 2 2 2 2 RNA helicase MeaB PF03308.16 EXF77901.1 - 0.00016 20.7 1.8 0.36 9.8 0.0 2.9 3 0 0 3 3 3 2 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_27 PF13514.6 EXF77901.1 - 0.00022 20.9 0.0 0.14 11.8 0.0 2.6 2 0 0 2 2 2 1 AAA domain Rad17 PF03215.15 EXF77901.1 - 0.00044 20.2 0.0 0.43 10.5 0.0 2.5 2 0 0 2 2 2 1 Rad17 P-loop domain G-alpha PF00503.20 EXF77901.1 - 0.00063 19.0 0.1 0.8 8.8 0.0 3.1 3 1 0 3 3 3 1 G-protein alpha subunit NACHT PF05729.12 EXF77901.1 - 0.00067 19.6 0.0 0.19 11.6 0.0 2.5 2 0 0 2 2 2 1 NACHT domain AAA_24 PF13479.6 EXF77901.1 - 0.00076 19.3 0.5 1.3 8.7 0.0 3.2 3 0 0 3 3 3 1 AAA domain MMS19_N PF14500.6 EXF77901.1 - 0.00086 19.0 0.8 0.22 11.1 0.5 2.8 2 0 0 2 2 2 1 Dos2-interacting transcription regulator of RNA-Pol-II DUF87 PF01935.17 EXF77901.1 - 0.0015 18.7 1.8 1.1 9.3 0.0 4.1 5 0 0 5 5 4 1 Helicase HerA, central domain AAA_14 PF13173.6 EXF77901.1 - 0.0017 18.4 0.0 4.5 7.3 0.0 3.4 3 0 0 3 3 3 0 AAA domain AAA_30 PF13604.6 EXF77901.1 - 0.0024 17.6 0.0 3.1 7.5 0.0 3.2 3 0 0 3 3 3 1 AAA domain cobW PF02492.19 EXF77901.1 - 0.0024 17.5 0.1 3.8 7.1 0.0 3.4 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain SbcCD_C PF13558.6 EXF77901.1 - 0.0036 17.5 0.0 1.1 9.6 0.0 3.4 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit NB-ARC PF00931.22 EXF77901.1 - 0.0061 15.8 0.1 0.33 10.1 0.0 2.6 2 0 0 2 2 2 1 NB-ARC domain PRK PF00485.18 EXF77901.1 - 0.0061 16.3 0.0 0.36 10.5 0.1 2.5 2 0 0 2 2 2 1 Phosphoribulokinase / Uridine kinase family Roc PF08477.13 EXF77901.1 - 0.0069 16.6 0.1 9.8 6.4 0.0 3.3 3 0 0 3 3 2 0 Ras of Complex, Roc, domain of DAPkinase DRIM PF07539.12 EXF77901.1 - 0.0091 14.3 1.1 0.33 9.2 0.3 2.4 2 1 0 2 2 2 1 Down-regulated in metastasis ATPase_2 PF01637.18 EXF77901.1 - 0.0096 15.9 0.1 3.5 7.5 0.0 3.3 3 0 0 3 3 2 0 ATPase domain predominantly from Archaea ATP_bind_1 PF03029.17 EXF77901.1 - 0.013 15.3 0.0 7.7 6.2 0.0 2.7 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein Septin PF00735.18 EXF77901.1 - 0.018 14.3 0.1 4.1 6.6 0.0 3.0 3 0 0 3 3 3 0 Septin CLP1_P PF16575.5 EXF77901.1 - 0.019 14.8 0.0 0.8 9.5 0.0 2.7 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop IstB_IS21 PF01695.17 EXF77901.1 - 0.027 14.2 0.0 5.6 6.7 0.0 2.9 3 0 0 3 3 2 0 IstB-like ATP binding protein AAA_7 PF12775.7 EXF77901.1 - 0.028 13.9 0.0 4.1 6.9 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region Ploopntkinase3 PF18751.1 EXF77901.1 - 0.03 14.2 0.1 5 7.0 0.0 2.5 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 AAA_13 PF13166.6 EXF77901.1 - 0.036 12.7 3.7 2.4 6.7 0.0 3.7 4 0 0 4 4 3 0 AAA domain Mg_chelatase PF01078.21 EXF77901.1 - 0.038 13.4 0.1 3.7 6.9 0.0 2.9 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI ATP-synt_ab PF00006.25 EXF77901.1 - 0.04 13.6 0.0 13 5.4 0.0 2.7 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain Cytidylate_kin PF02224.18 EXF77901.1 - 0.045 13.5 0.0 12 5.6 0.0 2.7 2 0 0 2 2 2 0 Cytidylate kinase DUF1280 PF06918.14 EXF77901.1 - 0.074 12.6 0.5 0.25 10.9 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1280) NTPase_1 PF03266.15 EXF77901.1 - 0.079 12.9 0.1 20 5.0 0.1 2.8 2 0 0 2 2 2 0 NTPase AAA_25 PF13481.6 EXF77901.1 - 0.084 12.4 0.0 12 5.5 0.0 3.0 2 0 0 2 2 2 0 AAA domain T2SSE PF00437.20 EXF77901.1 - 0.1 11.7 0.1 10 5.1 0.0 2.5 2 0 0 2 2 2 0 Type II/IV secretion system protein HEAT PF02985.22 EXF77901.1 - 0.1 12.9 0.0 37 4.9 0.0 3.7 3 0 0 3 3 2 0 HEAT repeat TsaE PF02367.17 EXF77901.1 - 0.12 12.4 0.1 55 3.8 0.0 3.2 2 1 1 3 3 3 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE MukB PF04310.12 EXF77901.1 - 0.13 12.1 0.1 17 5.1 0.0 2.4 2 0 0 2 2 2 0 MukB N-terminal FeoB_N PF02421.18 EXF77901.1 - 0.13 11.8 0.2 1.1 8.8 0.1 2.3 2 0 0 2 2 2 0 Ferrous iron transport protein B SpoIIIAH PF12685.7 EXF77901.1 - 0.39 10.5 5.7 0.1 12.4 1.1 2.4 2 1 0 2 2 2 0 SpoIIIAH-like protein AF-4 PF05110.13 EXF77902.1 - 2.9 5.9 3.9 4 5.4 3.9 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein p450 PF00067.22 EXF77903.1 - 1.7e-37 129.3 0.0 2.1e-37 129.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Dioxygenase_C PF00775.21 EXF77904.1 - 5.7e-09 35.7 0.0 4.8e-08 32.7 0.0 2.2 1 1 0 1 1 1 1 Dioxygenase UxaC PF02614.14 EXF77904.1 - 0.15 10.9 0.0 0.2 10.5 0.0 1.1 1 0 0 1 1 1 0 Glucuronate isomerase HET PF06985.11 EXF77905.1 - 7.3e-24 84.8 0.0 1.8e-23 83.5 0.0 1.7 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) RNase_H PF00075.24 EXF77906.1 - 9.1e-16 58.3 0.0 5.2e-15 55.9 0.0 1.9 1 1 0 1 1 1 1 RNase H RVT_3 PF13456.6 EXF77906.1 - 0.0077 16.0 0.0 1.2 9.0 0.0 2.3 2 0 0 2 2 2 2 Reverse transcriptase-like Glyco_hydro_5_C PF18564.1 EXF77907.1 - 3.5e-23 81.9 0.2 6.8e-23 81.0 0.2 1.5 1 0 0 1 1 1 1 Glycoside hydrolase family 5 C-terminal domain Cellulase PF00150.18 EXF77907.1 - 5.7e-12 45.7 0.0 0.00012 21.6 0.0 2.9 2 1 0 2 2 2 2 Cellulase (glycosyl hydrolase family 5) Aldo_ket_red PF00248.21 EXF77908.1 - 1.5e-41 142.6 0.1 2.2e-32 112.4 0.0 2.0 2 0 0 2 2 2 2 Aldo/keto reductase family DUF2110 PF09883.9 EXF77908.1 - 0.068 12.7 0.0 0.68 9.5 0.0 2.4 3 0 0 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2110) BPL_LplA_LipB PF03099.19 EXF77908.1 - 0.07 13.0 0.0 0.22 11.4 0.0 1.8 1 0 0 1 1 1 0 Biotin/lipoate A/B protein ligase family Phage_TAC_3 PF06896.11 EXF77909.1 - 0.077 13.6 0.0 0.14 12.7 0.0 1.4 1 0 0 1 1 1 0 Phage tail assembly chaperone proteins, TAC Glyco_hydro_47 PF01532.20 EXF77910.1 - 1e-168 562.0 0.0 1.3e-168 561.7 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Glyco_hydro_76 PF03663.14 EXF77910.1 - 0.0066 16.0 0.0 3.1 7.2 0.0 2.5 3 0 0 3 3 3 2 Glycosyl hydrolase family 76 PGF-CTERM PF18204.1 EXF77911.1 - 2.1 8.5 4.9 2.8 8.0 4.9 1.2 1 0 0 1 1 1 0 PGF-CTERM motif DUF3433 PF11915.8 EXF77912.1 - 4.7e-25 87.9 9.6 7.8e-17 61.5 2.7 3.6 4 0 0 4 4 4 2 Protein of unknown function (DUF3433) tRNA-synt_1c PF00749.21 EXF77915.1 - 4e-102 341.3 0.0 5.6e-102 340.8 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 EXF77915.1 - 1.6e-32 112.8 0.1 2e-31 109.2 0.0 2.6 3 0 0 3 3 3 1 tRNA synthetases class I (E and Q), anti-codon binding domain Hc1 PF07432.13 EXF77915.1 - 0.17 12.2 14.2 0.53 10.7 14.2 1.8 1 0 0 1 1 1 0 Histone H1-like protein Hc1 Macro PF01661.21 EXF77916.1 - 4.7e-39 133.1 0.2 9.1e-39 132.2 0.2 1.5 1 0 0 1 1 1 1 Macro domain Peptidase_S41 PF03572.18 EXF77917.1 - 0.00011 21.8 0.0 0.00029 20.4 0.0 1.8 2 0 0 2 2 2 1 Peptidase family S41 Lipocalin_5 PF13924.6 EXF77918.1 - 4.3e-24 84.9 0.0 8e-24 84.1 0.0 1.4 1 0 0 1 1 1 1 Lipocalin-like domain NACHT PF05729.12 EXF77918.1 - 7.4e-10 39.0 0.0 2.1e-09 37.5 0.0 1.8 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 EXF77918.1 - 0.0039 17.5 0.2 0.047 14.0 0.0 2.8 3 0 0 3 3 3 1 AAA domain ABC_tran PF00005.27 EXF77918.1 - 0.0063 17.0 0.1 0.02 15.4 0.1 1.8 1 0 0 1 1 1 1 ABC transporter AAA_16 PF13191.6 EXF77918.1 - 0.0066 16.9 0.2 0.054 13.9 0.0 2.7 3 1 0 3 3 3 1 AAA ATPase domain NTPase_1 PF03266.15 EXF77918.1 - 0.0073 16.2 0.5 0.36 10.7 0.1 2.4 2 0 0 2 2 2 1 NTPase AAA_29 PF13555.6 EXF77918.1 - 0.01 15.5 0.0 0.022 14.5 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_18 PF13238.6 EXF77918.1 - 0.016 15.7 0.0 0.051 14.1 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 EXF77918.1 - 0.016 15.7 0.1 0.016 15.7 0.1 2.0 2 1 0 2 2 2 0 AAA domain AAA_30 PF13604.6 EXF77918.1 - 0.15 11.8 0.0 0.35 10.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EXF77918.1 - 0.19 11.4 0.0 0.52 10.0 0.0 1.7 2 0 0 2 2 2 0 AAA domain AA_permease PF00324.21 EXF77919.1 - 1.5e-38 132.6 30.6 9.1e-24 83.9 22.7 2.0 2 0 0 2 2 2 2 Amino acid permease AA_permease_2 PF13520.6 EXF77919.1 - 3.2e-23 82.2 27.8 8.1e-16 57.9 20.7 2.0 2 0 0 2 2 2 2 Amino acid permease CBM_25 PF03423.13 EXF77919.1 - 0.041 14.1 0.2 0.086 13.1 0.2 1.5 1 0 0 1 1 1 0 Carbohydrate binding domain (family 25) DUF2061 PF09834.9 EXF77919.1 - 7.3 7.2 15.8 4.6 7.8 0.9 4.2 3 0 0 3 3 3 0 Predicted membrane protein (DUF2061) AAA_lid_8 PF17868.1 EXF77920.1 - 0.0077 16.1 0.1 0.014 15.2 0.1 1.4 1 0 0 1 1 1 1 AAA lid domain CorA PF01544.18 EXF77920.1 - 0.066 12.5 2.5 0.1 11.9 2.5 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Pkinase PF00069.25 EXF77921.1 - 7.5e-22 77.9 0.1 1.8e-21 76.7 0.1 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF77921.1 - 7.1e-15 55.0 0.0 7.8e-10 38.5 0.0 2.3 1 1 1 2 2 2 2 Protein tyrosine kinase Pox_ser-thr_kin PF05445.11 EXF77921.1 - 0.044 12.7 0.0 0.1 11.6 0.0 1.5 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Epimerase PF01370.21 EXF77922.1 - 7.3e-20 71.4 0.0 9.8e-20 71.0 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 EXF77922.1 - 2.9e-08 33.2 0.0 4.8e-08 32.4 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain GDP_Man_Dehyd PF16363.5 EXF77922.1 - 1.1e-06 28.3 0.0 1.5e-06 27.9 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 EXF77922.1 - 0.0005 19.2 0.0 0.0016 17.5 0.0 1.8 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Sacchrp_dh_NADP PF03435.18 EXF77922.1 - 0.0013 18.9 0.0 0.0026 18.0 0.0 1.5 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain KR PF08659.10 EXF77922.1 - 0.018 14.9 0.0 0.031 14.2 0.0 1.4 1 0 0 1 1 1 0 KR domain TrkA_N PF02254.18 EXF77922.1 - 0.052 13.8 0.0 0.13 12.5 0.0 1.6 1 0 0 1 1 1 0 TrkA-N domain CBS PF00571.28 EXF77924.1 - 1.9e-07 31.4 0.0 0.14 12.7 0.0 3.1 1 1 1 2 2 2 2 CBS domain Mito_carr PF00153.27 EXF77925.1 - 7.8e-45 150.7 7.9 1.3e-15 57.1 0.2 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Methyltransf_23 PF13489.6 EXF77926.1 - 3.5e-10 40.0 0.0 1.4e-05 24.9 0.0 2.3 1 1 1 2 2 2 2 Methyltransferase domain Methyltransf_11 PF08241.12 EXF77926.1 - 0.00028 21.5 0.0 0.0041 17.7 0.0 2.3 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF77926.1 - 0.0015 19.3 0.0 0.062 14.0 0.0 2.6 2 1 1 3 3 3 1 Methyltransferase domain Ubie_methyltran PF01209.18 EXF77926.1 - 0.0015 17.9 0.1 0.7 9.2 0.0 2.2 1 1 1 2 2 2 2 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.6 EXF77926.1 - 0.0016 19.1 0.1 1.5 9.6 0.0 2.5 1 1 1 2 2 2 2 Methyltransferase domain MTS PF05175.14 EXF77926.1 - 0.14 11.7 0.0 0.36 10.4 0.0 1.6 2 0 0 2 2 2 0 Methyltransferase small domain p450 PF00067.22 EXF77928.1 - 2.8e-28 98.9 0.0 1.8e-26 92.9 0.0 2.3 1 1 0 1 1 1 1 Cytochrome P450 EST1_DNA_bind PF10373.9 EXF77929.1 - 4.5e-16 59.2 0.0 7.9e-16 58.4 0.0 1.4 1 0 0 1 1 1 1 Est1 DNA/RNA binding domain Fungal_trans PF04082.18 EXF77931.1 - 1.7e-16 60.1 0.1 3e-16 59.2 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF77931.1 - 6.2e-07 29.4 8.9 1.2e-06 28.5 8.9 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-H2C2_2 PF13465.6 EXF77932.1 - 0.006 17.0 0.3 0.006 17.0 0.3 4.0 5 0 0 5 5 5 1 Zinc-finger double domain zf-C2H2 PF00096.26 EXF77932.1 - 0.034 14.6 0.8 0.034 14.6 0.8 4.5 4 0 0 4 4 4 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EXF77932.1 - 0.094 13.6 0.6 0.094 13.6 0.6 5.2 4 0 0 4 4 4 0 C2H2-type zinc finger HypA PF01155.19 EXF77932.1 - 0.21 11.6 0.9 0.37 10.8 0.9 1.5 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Fungal_trans PF04082.18 EXF77936.1 - 1.9e-26 92.7 0.0 3.2e-26 92.0 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF77936.1 - 1e-05 25.5 15.8 1.7e-05 24.8 15.8 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DHquinase_I PF01487.15 EXF77939.1 - 2.3e-44 152.3 0.0 3.5e-44 151.8 0.0 1.3 1 0 0 1 1 1 1 Type I 3-dehydroquinase CAP_N PF01213.19 EXF77939.1 - 3.6 7.0 5.8 6.1 6.2 5.8 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal MFS_1 PF07690.16 EXF77940.1 - 4.7e-34 117.9 51.9 4.7e-34 117.9 51.9 2.0 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF77940.1 - 4.1e-10 39.1 10.9 4.1e-10 39.1 10.9 1.8 2 0 0 2 2 2 1 Sugar (and other) transporter OATP PF03137.20 EXF77940.1 - 0.35 9.1 15.8 0.0077 14.6 3.5 2.9 3 1 0 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family Glyco_transf_90 PF05686.12 EXF77942.1 - 2.9e-08 33.1 0.0 0.0007 18.6 0.0 3.0 3 0 0 3 3 3 2 Glycosyl transferase family 90 Tctex-1 PF03645.13 EXF77944.1 - 7.4e-40 135.4 0.0 8.5e-40 135.2 0.0 1.0 1 0 0 1 1 1 1 Tctex-1 family PmbA_TldD PF01523.16 EXF77944.1 - 0.046 13.6 0.1 0.053 13.4 0.1 1.1 1 0 0 1 1 1 0 Putative modulator of DNA gyrase DUF202 PF02656.15 EXF77945.1 - 8.4e-16 58.2 3.5 8.4e-16 58.2 3.5 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF202) Alba PF01918.21 EXF77946.1 - 0.00078 19.2 0.1 0.0023 17.7 0.1 1.9 1 1 0 1 1 1 1 Alba UPF0449 PF15136.6 EXF77946.1 - 0.027 14.9 0.0 0.072 13.6 0.0 1.8 1 0 0 1 1 1 0 Uncharacterised protein family UPF0449 DUF3598 PF12204.8 EXF77946.1 - 0.16 11.4 0.2 0.71 9.3 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3598) Pkinase PF00069.25 EXF77948.1 - 3.1e-53 180.8 0.0 4.5e-53 180.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF77948.1 - 5.5e-31 107.8 0.0 7.1e-31 107.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EXF77948.1 - 1.6e-05 24.4 0.0 0.00022 20.7 0.0 2.0 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 EXF77948.1 - 0.0013 18.7 0.0 0.0033 17.4 0.0 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 EXF77948.1 - 0.0035 16.7 0.0 0.0063 15.9 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EXF77948.1 - 0.0077 15.0 0.0 0.011 14.5 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 EXF77948.1 - 0.078 11.9 0.0 0.11 11.4 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Fungal_trans PF04082.18 EXF77950.1 - 1.8e-05 23.9 0.0 3e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain GFO_IDH_MocA PF01408.22 EXF77951.1 - 4e-17 63.1 0.1 7.6e-17 62.2 0.1 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA PF01408.22 EXF77952.1 - 1e-16 61.8 0.0 1.9e-16 61.0 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold RTA1 PF04479.13 EXF77953.1 - 3.8e-68 229.2 4.5 5e-68 228.8 4.5 1.2 1 0 0 1 1 1 1 RTA1 like protein DUF4271 PF14093.6 EXF77953.1 - 0.13 12.1 10.6 0.63 9.9 2.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4271) 2TM PF13239.6 EXF77953.1 - 8.4 6.8 7.8 1.6 9.1 0.2 2.8 2 2 0 2 2 2 0 2TM domain ketoacyl-synt PF00109.26 EXF77954.1 - 4e-61 206.8 0.1 1.2e-59 202.0 0.1 2.0 1 1 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 EXF77954.1 - 1.8e-18 66.7 0.2 7e-18 64.8 0.0 1.9 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.23 EXF77954.1 - 0.1 12.0 0.1 0.14 11.5 0.1 1.3 1 0 0 1 1 1 0 Thiolase, N-terminal domain Carn_acyltransf PF00755.20 EXF77955.1 - 4.1e-96 322.9 0.0 7.2e-96 322.1 0.0 1.4 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase KR PF08659.10 EXF77955.1 - 2.6e-54 183.9 0.0 5.7e-54 182.7 0.0 1.7 1 0 0 1 1 1 1 KR domain Acyl_transf_1 PF00698.21 EXF77955.1 - 5.1e-53 180.6 0.1 1.2e-52 179.4 0.0 1.6 2 0 0 2 2 2 1 Acyl transferase domain PS-DH PF14765.6 EXF77955.1 - 1.5e-51 175.4 0.0 2.9e-51 174.5 0.0 1.5 1 0 0 1 1 1 1 Polyketide synthase dehydratase ADH_zinc_N_2 PF13602.6 EXF77955.1 - 1.2e-18 68.4 0.0 7.9e-17 62.6 0.0 2.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase KAsynt_C_assoc PF16197.5 EXF77955.1 - 3.1e-17 63.1 1.0 1.5e-08 35.1 0.1 2.9 2 0 0 2 2 2 2 Ketoacyl-synthetase C-terminal extension ADH_zinc_N PF00107.26 EXF77955.1 - 9e-14 51.6 0.0 3.3e-12 46.5 0.0 2.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase adh_short PF00106.25 EXF77955.1 - 1.2e-09 38.0 0.2 8.1e-09 35.2 0.0 2.3 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF77955.1 - 4.7e-08 32.9 0.0 1.2e-07 31.5 0.0 1.6 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase PP-binding PF00550.25 EXF77955.1 - 2.6e-07 30.9 0.2 6.8e-07 29.6 0.2 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site Methyltransf_12 PF08242.12 EXF77955.1 - 0.0015 19.3 0.0 0.005 17.5 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain ADH_N PF08240.12 EXF77955.1 - 0.0055 16.6 0.0 0.015 15.2 0.0 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Methyltransf_31 PF13847.6 EXF77955.1 - 0.019 14.7 0.0 0.12 12.2 0.0 2.3 2 0 0 2 2 2 0 Methyltransferase domain Collagen PF01391.18 EXF77955.1 - 0.042 13.6 2.5 0.088 12.6 2.5 1.4 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) Methyltransf_25 PF13649.6 EXF77955.1 - 0.088 13.5 0.0 0.35 11.6 0.0 2.2 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.12 EXF77955.1 - 0.12 13.0 0.0 0.49 11.1 0.0 2.1 1 0 0 1 1 1 0 Methyltransferase domain NAD_binding_10 PF13460.6 EXF77955.1 - 0.14 12.1 0.1 0.38 10.6 0.1 1.8 1 0 0 1 1 1 0 NAD(P)H-binding MFS_1 PF07690.16 EXF77956.1 - 5.6e-25 88.0 35.5 5.9e-22 78.1 15.0 2.5 3 0 0 3 3 3 2 Major Facilitator Superfamily FAD_binding_4 PF01565.23 EXF77957.1 - 9e-23 80.5 3.7 1.7e-22 79.7 3.7 1.5 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EXF77957.1 - 2.7e-10 40.2 0.0 6e-10 39.1 0.0 1.6 1 0 0 1 1 1 1 Berberine and berberine like NTP_transf_9 PF04248.12 EXF77958.1 - 4.3e-39 132.3 0.4 5.3e-31 106.4 0.1 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF427) DUF3425 PF11905.8 EXF77959.1 - 1.1e-10 41.5 1.3 2.2e-10 40.6 1.3 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) SET PF00856.28 EXF77959.1 - 0.09 13.2 0.0 0.88 9.9 0.0 2.2 2 0 0 2 2 2 0 SET domain AAA_16 PF13191.6 EXF77959.1 - 3.9 7.8 6.1 6.8 7.0 1.1 2.4 2 0 0 2 2 2 0 AAA ATPase domain p450 PF00067.22 EXF77960.1 - 6.7e-59 199.8 0.0 4.3e-58 197.2 0.0 2.1 1 1 0 1 1 1 1 Cytochrome P450 ADH_N PF08240.12 EXF77961.1 - 5.6e-24 84.1 1.5 1e-23 83.3 1.5 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EXF77961.1 - 1.2e-20 73.8 0.0 1.9e-20 73.2 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 EXF77961.1 - 8.6e-05 22.4 0.1 0.00031 20.6 0.0 1.8 2 0 0 2 2 2 1 N-terminal domain of oxidoreductase ADH_zinc_N_2 PF13602.6 EXF77961.1 - 0.00076 20.5 0.0 0.0012 19.9 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Aldedh PF00171.22 EXF77962.1 - 5.3e-150 500.0 0.0 6.6e-150 499.6 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family FAD_binding_3 PF01494.19 EXF77963.1 - 1.5e-33 116.5 0.0 6.8e-33 114.3 0.0 1.8 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.24 EXF77963.1 - 4.2e-09 36.5 0.1 0.00027 20.6 0.1 2.1 2 0 0 2 2 2 2 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 EXF77963.1 - 1.3e-07 31.0 0.2 0.00065 18.9 0.0 2.5 3 0 0 3 3 3 2 Lycopene cyclase protein Pyr_redox_2 PF07992.14 EXF77963.1 - 2.6e-06 26.9 0.7 0.0036 16.6 0.1 2.2 1 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EXF77963.1 - 1.1e-05 25.6 0.1 2.6e-05 24.4 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 EXF77963.1 - 4.3e-05 24.0 0.1 0.061 13.9 0.0 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 EXF77963.1 - 8.7e-05 22.0 0.0 0.12 11.6 0.0 2.4 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase HI0933_like PF03486.14 EXF77963.1 - 0.00041 19.2 0.2 0.33 9.6 0.1 2.2 2 0 0 2 2 2 2 HI0933-like protein FAD_binding_2 PF00890.24 EXF77963.1 - 0.00084 18.5 0.1 0.0016 17.6 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.6 EXF77963.1 - 0.015 14.6 0.1 4 6.6 0.1 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Myosin_N PF02736.19 EXF77963.1 - 0.015 15.1 0.7 0.034 14.0 0.7 1.5 1 0 0 1 1 1 0 Myosin N-terminal SH3-like domain Trp_halogenase PF04820.14 EXF77963.1 - 0.057 12.3 0.1 7.3 5.3 0.0 2.4 3 0 0 3 3 3 0 Tryptophan halogenase Thi4 PF01946.17 EXF77963.1 - 0.11 11.7 0.1 0.19 10.9 0.1 1.3 1 0 0 1 1 1 0 Thi4 family NAD_binding_9 PF13454.6 EXF77963.1 - 0.19 11.7 0.3 4.6 7.2 0.1 2.3 2 0 0 2 2 2 0 FAD-NAD(P)-binding Cutinase PF01083.22 EXF77964.1 - 1.9e-43 148.5 0.3 2.3e-43 148.2 0.3 1.1 1 0 0 1 1 1 1 Cutinase PE-PPE PF08237.11 EXF77964.1 - 3.4e-05 23.5 0.2 7.7e-05 22.4 0.1 1.6 2 0 0 2 2 2 1 PE-PPE domain VirJ PF06057.11 EXF77964.1 - 0.0089 15.9 0.0 0.016 15.1 0.0 1.3 1 0 0 1 1 1 1 Bacterial virulence protein (VirJ) Palm_thioest PF02089.15 EXF77964.1 - 0.032 14.0 0.0 0.046 13.5 0.0 1.3 1 0 0 1 1 1 0 Palmitoyl protein thioesterase DUF2974 PF11187.8 EXF77964.1 - 0.036 13.6 0.0 0.055 13.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) DUF676 PF05057.14 EXF77964.1 - 0.039 13.5 0.0 0.4 10.2 0.0 2.1 2 0 0 2 2 2 0 Putative serine esterase (DUF676) AA_permease PF00324.21 EXF77965.1 - 8.7e-126 420.3 37.0 1.1e-125 420.0 37.0 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EXF77965.1 - 4.7e-28 98.2 37.9 5.7e-28 97.9 37.9 1.0 1 0 0 1 1 1 1 Amino acid permease Erf4 PF10256.9 EXF77966.1 - 1.3e-06 28.5 0.0 3.6e-06 27.1 0.0 1.7 1 1 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family DUF4646 PF15496.6 EXF77966.1 - 0.026 15.1 0.0 0.046 14.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4646) FAD_binding_4 PF01565.23 EXF77967.1 - 3.5e-20 72.2 3.3 3.5e-20 72.2 3.3 2.2 2 0 0 2 2 2 1 FAD binding domain BBE PF08031.12 EXF77967.1 - 5.8e-12 45.5 1.5 1.3e-11 44.3 0.4 2.1 2 0 0 2 2 2 1 Berberine and berberine like Cytokin-bind PF09265.10 EXF77967.1 - 0.11 11.9 0.5 0.27 10.6 0.5 1.5 1 1 0 1 1 1 0 Cytokinin dehydrogenase 1, FAD and cytokinin binding CFEM PF05730.11 EXF77968.1 - 5.2e-12 45.7 11.7 5.2e-12 45.7 11.7 1.7 2 0 0 2 2 2 1 CFEM domain Defensin_2 PF01097.18 EXF77968.1 - 0.00091 19.1 3.4 0.0029 17.5 3.4 1.9 1 0 0 1 1 1 1 Arthropod defensin Gamma-thionin PF00304.20 EXF77968.1 - 0.0023 18.1 2.3 0.0023 18.1 2.3 1.8 2 0 0 2 2 2 1 Gamma-thionin family Ank_2 PF12796.7 EXF77969.1 - 3.9e-27 94.7 1.2 5.8e-10 39.6 0.0 4.8 2 2 1 4 4 4 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EXF77969.1 - 3.5e-20 71.8 2.2 1.2e-06 28.6 0.1 5.8 5 0 0 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EXF77969.1 - 2.6e-18 64.2 0.9 0.057 14.0 0.1 8.1 8 0 0 8 8 8 4 Ankyrin repeat Ank_4 PF13637.6 EXF77969.1 - 1.1e-16 61.0 9.0 1.4e-06 28.8 0.1 7.0 6 1 2 8 8 8 3 Ankyrin repeats (many copies) Ank PF00023.30 EXF77969.1 - 6.5e-15 54.8 1.2 0.00019 21.7 0.1 6.7 7 0 0 7 7 7 3 Ankyrin repeat Helo_like_N PF17111.5 EXF77969.1 - 0.00038 19.9 0.3 0.00066 19.1 0.3 1.4 1 1 0 1 1 1 1 Fungal N-terminal domain of STAND proteins Metallophos PF00149.28 EXF77970.1 - 1.5e-14 55.0 0.1 3.8e-14 53.7 0.1 1.7 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EXF77970.1 - 9.2e-06 25.9 0.0 0.00011 22.5 0.0 2.2 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Trypsin PF00089.26 EXF77971.1 - 2e-09 37.6 0.1 5.2e-09 36.3 0.1 1.7 1 1 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 EXF77971.1 - 3.1e-09 37.9 0.5 1e-08 36.2 0.0 2.2 2 0 0 2 2 2 1 Trypsin-like peptidase domain Peptidase_C3 PF00548.20 EXF77971.1 - 0.0054 16.7 0.1 0.01 15.8 0.1 1.4 1 0 0 1 1 1 1 3C cysteine protease (picornain 3C) Ribosomal_S8e PF01201.22 EXF77971.1 - 0.084 13.0 0.5 0.16 12.1 0.5 1.4 1 0 0 1 1 1 0 Ribosomal protein S8e Pectinesterase PF01095.19 EXF77973.1 - 2.1e-48 164.6 10.2 2.8e-48 164.2 10.2 1.1 1 0 0 1 1 1 1 Pectinesterase Methyltransf_PK PF05891.12 EXF77974.1 - 2.3e-83 279.0 0.0 2.6e-83 278.9 0.0 1.0 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_23 PF13489.6 EXF77974.1 - 0.00055 19.8 0.0 0.0012 18.7 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF77974.1 - 0.0028 18.3 0.0 0.0059 17.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF77974.1 - 0.016 15.8 0.0 0.028 15.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain SR-25 PF10500.9 EXF77975.1 - 0.0032 17.1 12.8 0.0044 16.7 12.8 1.1 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein AP3D1 PF06375.11 EXF77975.1 - 0.25 11.6 7.2 0.4 10.9 7.2 1.3 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 GAGA_bind PF06217.12 EXF77975.1 - 0.33 11.2 6.7 0.43 10.8 6.7 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family Rtf2 PF04641.12 EXF77975.1 - 1.8 7.8 12.0 2.7 7.3 12.0 1.2 1 0 0 1 1 1 0 Rtf2 RING-finger SOBP PF15279.6 EXF77975.1 - 4.3 7.9 14.4 5.1 7.6 14.4 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein Red1 PF07964.11 EXF77975.1 - 4.3 5.4 8.3 5 5.2 8.3 1.0 1 0 0 1 1 1 0 Rec10 / Red1 TAF4 PF05236.14 EXF77975.1 - 4.3 7.0 15.7 5.6 6.6 15.7 1.1 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family Chitin_bind_1 PF00187.19 EXF77977.1 - 5.4e-27 94.0 193.6 2.3e-07 31.1 25.7 8.5 8 1 1 9 9 9 6 Chitin recognition protein Polysacc_deac_1 PF01522.21 EXF77977.1 - 1.2e-22 80.2 0.1 1.9e-22 79.5 0.1 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase Plasmodium_Vir PF05795.11 EXF77978.1 - 0.22 10.9 7.6 0.33 10.3 7.6 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein SRP-alpha_N PF04086.13 EXF77978.1 - 0.27 11.1 14.8 0.39 10.6 14.8 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Tim54 PF11711.8 EXF77978.1 - 1.1 8.0 14.6 1.9 7.2 14.6 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DDHD PF02862.17 EXF77978.1 - 1.1 9.4 3.2 1.7 8.8 3.2 1.4 1 0 0 1 1 1 0 DDHD domain Presenilin PF01080.17 EXF77978.1 - 3 6.5 9.5 4.8 5.8 9.5 1.3 1 0 0 1 1 1 0 Presenilin NPR3 PF03666.13 EXF77978.1 - 7 5.3 9.2 9.5 4.9 9.2 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 CDC45 PF02724.14 EXF77978.1 - 8.1 4.6 13.7 10 4.2 13.7 1.1 1 0 0 1 1 1 0 CDC45-like protein TPR_2 PF07719.17 EXF77980.1 - 1.5e-09 37.2 3.2 0.038 14.1 0.1 7.0 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_14 PF13428.6 EXF77980.1 - 2.2e-09 37.3 9.9 0.022 15.6 0.1 7.4 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_8 PF13181.6 EXF77980.1 - 3.7e-06 26.7 0.4 0.11 12.8 0.0 5.5 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_1 PF00515.28 EXF77980.1 - 3.9e-06 26.5 1.2 1.9 8.5 0.0 5.5 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_19 PF14559.6 EXF77980.1 - 1e-05 26.0 5.6 0.0057 17.1 0.1 4.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 EXF77980.1 - 0.00013 22.6 16.6 1.3 9.7 0.0 6.9 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_17 PF13431.6 EXF77980.1 - 0.00033 20.8 5.9 0.034 14.5 0.1 4.8 5 1 1 6 6 5 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EXF77980.1 - 0.008 16.4 0.6 30 4.9 0.0 4.5 4 0 0 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 EXF77980.1 - 0.016 15.2 2.1 5.3 7.3 0.0 5.4 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_6 PF13174.6 EXF77980.1 - 0.24 12.1 4.0 8.6 7.2 0.0 4.8 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_9 PF13371.6 EXF77980.1 - 0.24 11.6 3.7 56 4.0 0.0 4.4 5 0 0 5 5 5 0 Tetratricopeptide repeat RIX1 PF08167.12 EXF77981.1 - 1.5e-62 210.7 0.0 3.1e-62 209.7 0.0 1.5 1 0 0 1 1 1 1 rRNA processing/ribosome biogenesis SNAPc19 PF15497.6 EXF77981.1 - 7.7 7.0 15.5 9 6.8 6.7 2.8 3 0 0 3 3 3 0 snRNA-activating protein complex subunit 19, SNAPc subunit 19 WW PF00397.26 EXF77982.1 - 3.1e-08 33.6 2.8 7.4e-08 32.4 2.8 1.7 1 0 0 1 1 1 1 WW domain WRW PF10206.9 EXF77982.1 - 0.016 15.6 0.3 0.031 14.6 0.3 1.4 1 0 0 1 1 1 0 Mitochondrial F1F0-ATP synthase, subunit f Fungal_trans PF04082.18 EXF77983.1 - 0.0043 16.1 0.0 0.008 15.2 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Glyco_hydro_16 PF00722.21 EXF77984.1 - 1.6e-09 37.5 4.2 2.4e-09 36.9 4.2 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 PTPLA PF04387.14 EXF77985.1 - 4.2e-57 192.4 16.6 6.2e-57 191.9 16.6 1.2 1 0 0 1 1 1 1 Protein tyrosine phosphatase-like protein, PTPLA Abhydrolase_6 PF12697.7 EXF77986.1 - 3.9e-05 24.4 4.2 0.00011 22.8 4.2 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family DUF676 PF05057.14 EXF77986.1 - 0.00016 21.3 0.0 0.00026 20.6 0.0 1.4 1 0 0 1 1 1 1 Putative serine esterase (DUF676) PGAP1 PF07819.13 EXF77986.1 - 0.0021 17.8 0.0 0.0043 16.8 0.0 1.6 1 0 0 1 1 1 1 PGAP1-like protein Hydrolase_4 PF12146.8 EXF77986.1 - 0.0086 15.4 0.0 0.059 12.6 0.0 2.1 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.13 EXF77986.1 - 0.11 12.4 0.8 0.26 11.1 0.0 2.1 2 0 0 2 2 2 0 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 EXF77986.1 - 0.18 11.6 0.1 2.1 8.1 0.0 2.6 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase HET PF06985.11 EXF77987.1 - 1.9e-11 44.5 6.8 6.4e-09 36.3 1.3 2.6 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) DIOX_N PF14226.6 EXF77988.1 - 3.4e-24 85.8 0.0 6.6e-24 84.9 0.0 1.4 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EXF77988.1 - 3.9e-20 72.2 0.0 6.5e-20 71.5 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Amidohydro_2 PF04909.14 EXF77989.1 - 6.1e-31 108.3 0.0 8.6e-31 107.8 0.0 1.2 1 0 0 1 1 1 1 Amidohydrolase TatD_DNase PF01026.21 EXF77989.1 - 0.043 13.2 0.0 0.081 12.3 0.0 1.4 1 0 0 1 1 1 0 TatD related DNase TruD PF01142.18 EXF77990.1 - 7.8e-60 202.8 0.0 1.3e-58 198.8 0.0 2.1 2 0 0 2 2 2 2 tRNA pseudouridine synthase D (TruD) Pkinase PF00069.25 EXF77991.1 - 8.7e-63 212.1 0.0 1e-62 211.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF77991.1 - 1.1e-34 119.9 0.0 1.5e-34 119.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EXF77991.1 - 2.1e-05 24.0 0.0 3.2e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 Kinase-like FTA2 PF13095.6 EXF77991.1 - 0.00051 19.7 0.0 0.82 9.2 0.0 2.2 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 EXF77991.1 - 0.001 18.0 0.0 0.0014 17.5 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase DEAD PF00270.29 EXF77992.1 - 1.6e-40 138.7 0.0 3.7e-40 137.6 0.0 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EXF77992.1 - 9.8e-30 103.2 0.0 3.9e-29 101.2 0.0 2.0 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EXF77992.1 - 4.5e-06 26.8 0.0 1.4e-05 25.2 0.0 1.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit SNF2_N PF00176.23 EXF77992.1 - 0.0043 15.8 0.0 0.006 15.3 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain PBP1_TM PF14812.6 EXF77992.1 - 0.11 12.9 1.6 0.28 11.6 1.6 1.6 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Kelch_5 PF13854.6 EXF77996.1 - 3.8e-10 39.5 13.1 5e-10 39.1 0.1 5.0 5 0 0 5 5 5 1 Kelch motif SKG6 PF08693.10 EXF77996.1 - 1.8e-06 27.2 0.2 3.3e-06 26.4 0.2 1.5 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Kelch_1 PF01344.25 EXF77996.1 - 0.0045 16.5 0.3 0.098 12.3 0.2 2.9 2 0 0 2 2 2 1 Kelch motif Kelch_2 PF07646.15 EXF77996.1 - 0.0072 16.3 4.4 0.95 9.5 0.0 5.0 6 0 0 6 6 6 1 Kelch motif Kelch_6 PF13964.6 EXF77996.1 - 0.034 14.4 12.4 2.1 8.7 0.9 4.9 4 1 1 5 5 5 0 Kelch motif CD99L2 PF12301.8 EXF77996.1 - 0.12 12.6 1.3 0.3 11.4 1.3 1.7 1 0 0 1 1 1 0 CD99 antigen like protein 2 Gram_pos_anchor PF00746.21 EXF77996.1 - 0.18 11.8 2.2 0.46 10.5 2.2 1.8 1 0 0 1 1 1 0 LPXTG cell wall anchor motif Mucin15 PF15672.5 EXF77996.1 - 0.3 10.6 3.6 0.3 10.6 0.2 2.3 2 0 0 2 2 2 0 Cell-membrane associated Mucin15 AF-4 PF05110.13 EXF77996.1 - 8.3 4.4 13.5 13 3.7 13.5 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein GCV_T PF01571.21 EXF77997.1 - 2.9e-05 23.6 0.0 5.2e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain DnaJ PF00226.31 EXF77998.1 - 5.3e-14 52.1 2.4 3.5e-13 49.5 0.7 2.5 2 0 0 2 2 2 1 DnaJ domain WDCP PF15390.6 EXF77998.1 - 2.2 6.5 5.0 3.1 6.1 5.0 1.3 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family SAD_SRA PF02182.17 EXF77999.1 - 9.2e-07 28.7 0.7 1.7e-06 27.9 0.2 1.7 2 0 0 2 2 2 1 SAD/SRA domain Catalase PF00199.19 EXF78000.1 - 7.2e-161 535.6 0.1 9e-161 535.2 0.1 1.1 1 0 0 1 1 1 1 Catalase Catalase_C PF18011.1 EXF78000.1 - 5.1e-46 156.1 0.5 8.1e-46 155.4 0.5 1.3 1 0 0 1 1 1 1 C-terminal domain found in long catalases Catalase-rel PF06628.12 EXF78000.1 - 5.5e-20 71.3 0.0 1.1e-19 70.4 0.0 1.5 1 0 0 1 1 1 1 Catalase-related immune-responsive Ribosomal_S8 PF00410.19 EXF78001.1 - 5.9e-22 78.0 0.0 7.8e-22 77.6 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S8 Ribosomal_L7Ae PF01248.26 EXF78002.1 - 4.4e-28 96.9 1.0 5.7e-28 96.5 1.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family PELOTA_1 PF15608.6 EXF78002.1 - 0.09 12.7 0.0 0.16 11.8 0.0 1.3 1 0 0 1 1 1 0 PELOTA RNA binding domain Rotamase_3 PF13616.6 EXF78003.1 - 1.3e-17 64.4 0.1 2.6e-17 63.4 0.1 1.5 1 1 0 1 1 1 1 PPIC-type PPIASE domain Rotamase PF00639.21 EXF78003.1 - 1.7e-16 60.9 1.0 3.8e-16 59.8 0.0 1.8 1 1 1 2 2 2 1 PPIC-type PPIASE domain Rotamase_2 PF13145.6 EXF78003.1 - 4.6e-05 24.3 1.2 7.7e-05 23.5 1.2 1.6 1 1 0 1 1 1 1 PPIC-type PPIASE domain DUF563 PF04577.14 EXF78004.1 - 1.2e-31 110.5 0.0 1.8e-31 109.9 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF563) Asp PF00026.23 EXF78005.1 - 0.0013 18.3 0.3 0.0041 16.6 0.2 1.8 2 0 0 2 2 2 1 Eukaryotic aspartyl protease VSP PF03302.13 EXF78005.1 - 0.026 13.4 1.8 0.043 12.7 1.8 1.3 1 0 0 1 1 1 0 Giardia variant-specific surface protein Gram_pos_anchor PF00746.21 EXF78005.1 - 1.4 8.9 5.0 0.69 9.9 1.9 2.1 2 0 0 2 2 2 0 LPXTG cell wall anchor motif GST_N_3 PF13417.6 EXF78006.1 - 6.3e-15 55.4 0.0 1.1e-14 54.5 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 EXF78006.1 - 8e-15 55.0 0.0 1.8e-14 53.8 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EXF78006.1 - 1.6e-13 50.7 0.1 5.2e-13 49.0 0.0 1.7 1 1 1 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 EXF78006.1 - 1.7e-10 41.1 0.0 3.1e-10 40.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EXF78006.1 - 3.7e-10 39.9 0.0 7e-10 39.0 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EXF78006.1 - 1.1e-08 34.9 0.6 2.2e-08 34.0 0.6 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain NADH_u_ox_C PF12853.7 EXF78006.1 - 0.012 15.5 0.4 0.028 14.4 0.1 1.8 2 0 0 2 2 2 0 C-terminal of NADH-ubiquinone oxidoreductase 21 kDa subunit MFS_1 PF07690.16 EXF78007.1 - 1.1e-21 77.2 44.1 1.1e-21 77.2 44.1 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF78007.1 - 5.4e-09 35.4 26.4 1.7e-08 33.8 18.9 2.2 1 1 1 2 2 2 1 Sugar (and other) transporter MMPL PF03176.15 EXF78007.1 - 0.0096 14.9 1.4 0.025 13.5 1.4 1.6 1 0 0 1 1 1 1 MMPL family PhoLip_ATPase_C PF16212.5 EXF78008.1 - 4.7e-81 272.2 21.2 4.7e-81 272.2 21.2 2.3 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EXF78008.1 - 5.4e-27 93.3 7.1 1.4e-26 92.0 7.1 1.7 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 EXF78008.1 - 7.7e-12 45.1 0.0 3.8e-11 42.9 0.0 2.0 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EXF78008.1 - 5.7e-11 43.1 3.7 7.8e-07 29.6 0.9 3.1 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 EXF78008.1 - 7.9e-08 32.0 0.0 1.8e-07 30.9 0.0 1.6 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase_3 PF08282.12 EXF78008.1 - 0.0017 18.2 0.5 0.013 15.2 0.3 2.2 1 1 1 2 2 2 1 haloacid dehalogenase-like hydrolase DNA_III_psi PF03603.13 EXF78008.1 - 0.18 12.0 0.2 0.39 11.0 0.2 1.5 1 0 0 1 1 1 0 DNA polymerase III psi subunit Cript PF10235.9 EXF78009.1 - 1.1e-20 74.0 10.3 1.9e-20 73.2 10.3 1.4 1 0 0 1 1 1 1 Microtubule-associated protein CRIPT DZR PF12773.7 EXF78009.1 - 0.19 11.8 17.1 0.11 12.5 10.0 2.8 1 1 1 2 2 2 0 Double zinc ribbon zf-ribbon_3 PF13248.6 EXF78009.1 - 0.56 9.7 13.7 0.71 9.4 2.9 3.2 2 1 1 3 3 3 0 zinc-ribbon domain DUF2039 PF10217.9 EXF78009.1 - 0.6 10.5 16.8 0.068 13.5 10.7 2.1 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2039) CEBP_ZZ PF16366.5 EXF78009.1 - 1.4 9.2 8.1 0.3 11.4 4.2 1.8 2 0 0 2 2 2 0 Cytoplasmic polyadenylation element-binding protein ZZ domain zinc_ribbon_2 PF13240.6 EXF78009.1 - 1.9 8.3 14.1 2.2 8.1 1.9 3.2 3 0 0 3 3 3 0 zinc-ribbon domain zinc_ribbon_15 PF17032.5 EXF78009.1 - 2.1 9.1 13.2 1.6 9.5 8.6 2.7 2 1 0 2 2 2 0 zinc-ribbon family zf-C3HC4_3 PF13920.6 EXF78009.1 - 5.1 7.0 12.3 8.9 6.3 8.1 2.7 2 1 1 3 3 3 0 Zinc finger, C3HC4 type (RING finger) Abhydrolase_1 PF00561.20 EXF78010.1 - 2.3e-27 96.3 0.1 2.6e-21 76.4 0.1 2.0 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EXF78010.1 - 4.3e-18 66.7 0.0 6.3e-18 66.2 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EXF78010.1 - 2.3e-13 50.0 0.0 1e-12 47.9 0.0 1.8 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_2 PF02230.16 EXF78010.1 - 0.058 13.2 0.0 0.32 10.8 0.0 2.1 2 1 1 3 3 3 0 Phospholipase/Carboxylesterase Abhydrolase_4 PF08386.10 EXF78010.1 - 0.073 13.2 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 TAP-like protein Pinin_SDK_memA PF04696.13 EXF78011.1 - 2.8e-33 114.7 15.8 2.8e-33 114.7 15.8 3.4 4 0 0 4 4 4 1 pinin/SDK/memA/ protein conserved region Pex26 PF07163.12 EXF78011.1 - 0.0029 17.0 2.5 0.0029 17.0 2.5 2.7 3 0 0 3 3 3 1 Pex26 protein PHF5 PF03660.14 EXF78012.1 - 4e-52 174.8 10.4 4.6e-52 174.6 10.4 1.0 1 0 0 1 1 1 1 PHF5-like protein PolC_DP2 PF03833.13 EXF78012.1 - 0.64 7.8 7.7 0.64 7.8 7.7 1.2 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 DZR PF12773.7 EXF78012.1 - 2.5 8.2 15.6 5.6 7.1 1.9 3.0 1 1 1 2 2 2 0 Double zinc ribbon CAF1 PF04857.20 EXF78013.1 - 1.6e-82 277.2 0.0 1.9e-82 277.0 0.0 1.0 1 0 0 1 1 1 1 CAF1 family ribonuclease DNA_pol_A_exo1 PF01612.20 EXF78013.1 - 0.012 15.3 0.0 0.12 12.1 0.0 2.2 2 0 0 2 2 2 0 3'-5' exonuclease MRP-L46 PF11788.8 EXF78014.1 - 6.4e-24 85.0 0.0 1.1e-23 84.2 0.0 1.4 1 0 0 1 1 1 1 39S mitochondrial ribosomal protein L46 NUDIX PF00293.28 EXF78014.1 - 0.02 15.0 0.3 0.047 13.7 0.3 1.6 1 1 0 1 1 1 0 NUDIX domain RPA PF10134.9 EXF78014.1 - 0.085 12.3 0.0 0.14 11.7 0.0 1.2 1 0 0 1 1 1 0 Replication initiator protein A zf-rbx1 PF12678.7 EXF78015.1 - 3.7e-11 43.1 14.9 2.9e-08 33.9 0.4 3.8 3 1 1 4 4 4 2 RING-H2 zinc finger domain zf-RING_2 PF13639.6 EXF78015.1 - 8.8e-10 38.8 20.7 3.1e-08 33.8 1.0 3.5 3 0 0 3 3 3 2 Ring finger domain PHD PF00628.29 EXF78015.1 - 9.3e-09 35.0 7.7 9.3e-09 35.0 7.7 2.6 2 0 0 2 2 2 1 PHD-finger PHD_2 PF13831.6 EXF78015.1 - 4.9e-06 26.0 3.0 4.9e-06 26.0 3.0 2.4 2 0 0 2 2 2 1 PHD-finger Prok-RING_4 PF14447.6 EXF78015.1 - 1.9e-05 24.4 0.9 1.9e-05 24.4 0.9 3.0 4 0 0 4 4 2 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 EXF78015.1 - 3.5e-05 23.6 1.0 3.5e-05 23.6 1.0 3.5 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EXF78015.1 - 5.2e-05 23.0 0.6 5.2e-05 23.0 0.6 3.6 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EXF78015.1 - 7.8e-05 22.5 4.0 7.8e-05 22.5 4.0 3.4 2 2 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EXF78015.1 - 0.00021 21.2 0.5 0.00021 21.2 0.5 3.1 3 0 0 3 3 3 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 EXF78015.1 - 0.00055 19.9 8.6 0.014 15.4 0.2 2.6 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 11 RING-H2 finger PHF5 PF03660.14 EXF78015.1 - 0.0016 18.6 1.7 0.0016 18.6 1.7 2.3 3 0 0 3 3 2 1 PHF5-like protein zf-PHD-like PF15446.6 EXF78015.1 - 0.0037 16.9 2.1 0.0037 16.9 2.1 2.4 2 0 0 2 2 2 1 PHD/FYVE-zinc-finger like domain Zn_ribbon_17 PF17120.5 EXF78015.1 - 0.0044 16.6 1.5 0.0044 16.6 1.5 2.4 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type zf-RING_UBOX PF13445.6 EXF78015.1 - 0.012 15.6 0.1 0.012 15.6 0.1 4.0 3 1 1 4 4 4 0 RING-type zinc-finger Rtf2 PF04641.12 EXF78015.1 - 0.023 14.1 1.2 0.11 11.8 0.0 2.3 2 0 0 2 2 2 0 Rtf2 RING-finger zf-P11 PF03854.14 EXF78015.1 - 0.044 13.4 0.6 0.044 13.4 0.6 2.2 2 0 0 2 2 2 0 P-11 zinc finger Prok-RING_1 PF14446.6 EXF78015.1 - 0.31 11.0 10.6 0.16 11.9 2.5 2.9 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 zf-RING_6 PF14835.6 EXF78015.1 - 1 9.2 4.1 0.25 11.2 0.1 1.9 2 0 0 2 2 2 0 zf-RING of BARD1-type protein zf-RING_9 PF13901.6 EXF78015.1 - 1.3 8.9 10.6 3.8 7.4 0.5 2.4 2 0 0 2 2 2 0 Putative zinc-RING and/or ribbon DUF1644 PF07800.12 EXF78015.1 - 1.8 8.6 7.4 1.9 8.5 0.6 2.8 3 0 0 3 3 2 0 Protein of unknown function (DUF1644) Ribosomal_L37ae PF01780.19 EXF78016.1 - 1.5e-39 134.0 7.5 1.9e-39 133.6 7.5 1.1 1 0 0 1 1 1 1 Ribosomal L37ae protein family zf-RING_13 PF17977.1 EXF78016.1 - 0.08 13.1 2.6 0.14 12.3 2.6 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain C1_2 PF03107.16 EXF78016.1 - 0.12 12.7 2.3 5.6 7.4 0.1 2.2 1 1 1 2 2 2 0 C1 domain DUF1451 PF07295.11 EXF78016.1 - 0.25 11.4 1.0 0.37 10.8 1.0 1.2 1 0 0 1 1 1 0 Zinc-ribbon containing domain Zn_Tnp_IS1595 PF12760.7 EXF78016.1 - 0.31 11.1 3.7 0.53 10.3 3.7 1.4 1 0 0 1 1 1 0 Transposase zinc-ribbon domain Sacchrp_dh_NADP PF03435.18 EXF78017.1 - 7.6e-14 52.1 0.0 1.5e-13 51.1 0.0 1.5 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain DUF155 PF02582.14 EXF78018.1 - 3e-53 180.5 0.2 4.4e-53 180.0 0.2 1.3 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 HMG_box PF00505.19 EXF78019.1 - 1.6e-12 47.6 2.0 4e-12 46.4 2.0 1.7 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EXF78019.1 - 3.3e-06 27.6 3.4 3.3e-06 27.6 3.4 2.3 3 0 0 3 3 3 1 HMG-box domain CCDC106 PF15794.5 EXF78019.1 - 0.00086 19.1 0.7 0.00086 19.1 0.7 2.2 2 0 0 2 2 2 1 Coiled-coil domain-containing protein 106 HAUS4 PF14735.6 EXF78019.1 - 0.036 13.8 0.0 0.036 13.8 0.0 1.6 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 4 SlyX PF04102.12 EXF78019.1 - 0.39 11.4 8.8 0.59 10.8 0.2 3.4 2 1 1 3 3 3 0 SlyX ALMT PF11744.8 EXF78019.1 - 5.6 5.7 4.8 17 4.1 0.0 2.1 2 0 0 2 2 2 0 Aluminium activated malate transporter Atg14 PF10186.9 EXF78019.1 - 9 5.3 8.6 2 7.4 1.8 2.1 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Cpn60_TCP1 PF00118.24 EXF78020.1 - 3.4e-151 504.2 6.1 3.8e-151 504.1 6.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family EAL PF00563.20 EXF78020.1 - 0.0016 18.0 0.0 0.0036 16.8 0.0 1.5 1 0 0 1 1 1 1 EAL domain TetR_C_14 PF17754.1 EXF78020.1 - 0.014 15.4 0.0 1.5 8.8 0.0 2.5 2 0 0 2 2 2 0 MftR C-terminal domain PP1_inhibitor PF05361.12 EXF78020.1 - 0.053 13.5 0.2 0.26 11.3 0.2 2.2 2 1 1 3 3 3 0 PKC-activated protein phosphatase-1 inhibitor PrpR_N PF06506.11 EXF78020.1 - 0.053 13.1 0.1 0.2 11.2 0.1 2.0 2 0 0 2 2 2 0 Propionate catabolism activator FAD_binding_4 PF01565.23 EXF78021.1 - 1.7e-15 57.0 0.1 2.4e-15 56.5 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EXF78021.1 - 4.4e-05 23.5 0.2 8.9e-05 22.5 0.2 1.5 1 0 0 1 1 1 1 Berberine and berberine like adh_short PF00106.25 EXF78022.1 - 4.2e-34 117.7 0.0 5.3e-34 117.4 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF78022.1 - 1.9e-26 93.1 0.0 2.4e-26 92.7 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase SSP160 PF06933.11 EXF78022.1 - 0.0023 16.2 0.2 0.0031 15.8 0.2 1.1 1 0 0 1 1 1 1 Special lobe-specific silk protein SSP160 KR PF08659.10 EXF78022.1 - 0.022 14.7 0.0 0.075 12.9 0.0 1.8 1 1 0 1 1 1 0 KR domain Sugar_tr PF00083.24 EXF78023.1 - 3.5e-73 247.0 21.5 3.9e-73 246.9 21.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF78023.1 - 3.2e-25 88.8 49.0 4.7e-19 68.5 28.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Fungal_trans PF04082.18 EXF78024.1 - 1.8e-21 76.3 0.2 2.9e-21 75.7 0.2 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF78024.1 - 1.1e-06 28.7 5.2 3.5e-06 27.0 5.2 1.9 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain AMP-binding PF00501.28 EXF78025.1 - 1.2e-88 297.5 0.0 1.7e-88 297.0 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme adh_short PF00106.25 EXF78026.1 - 2.4e-17 63.0 0.0 3e-17 62.7 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF78026.1 - 4.2e-11 42.9 0.0 5e-11 42.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Cyclase PF04199.13 EXF78027.1 - 6.3e-12 45.9 0.0 9.3e-12 45.4 0.0 1.4 1 1 0 1 1 1 1 Putative cyclase F-box-like PF12937.7 EXF78028.1 - 0.0092 15.9 0.5 0.019 14.8 0.5 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EXF78028.1 - 0.0095 15.8 0.2 0.018 14.9 0.2 1.4 1 0 0 1 1 1 1 F-box domain UBM PF14377.6 EXF78028.1 - 0.026 14.0 0.0 0.041 13.4 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin binding region HNH_2 PF13391.6 EXF78029.1 - 6.1e-07 29.5 0.0 1.7e-06 28.1 0.0 1.8 1 0 0 1 1 1 1 HNH endonuclease ORC6 PF05460.13 EXF78029.1 - 0.13 11.5 3.3 0.2 10.9 3.3 1.2 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) DUF3328 PF11807.8 EXF78030.1 - 2.4e-29 102.7 0.5 7.7e-29 101.0 0.5 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF3328) DUF3328 PF11807.8 EXF78032.1 - 2.1e-20 73.5 1.7 2.8e-20 73.1 1.7 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF3328) 2OG-FeII_Oxy_3 PF13640.6 EXF78033.1 - 8.9e-09 36.1 0.0 1.5e-08 35.4 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Lbh PF15317.6 EXF78034.1 - 1.2 10.0 9.3 35 5.3 0.1 5.4 1 1 7 8 8 8 0 Cardiac transcription factor regulator, Developmental protein PH_10 PF15411.6 EXF78035.1 - 9.4e-30 103.4 0.5 1.6e-29 102.7 0.5 1.4 1 0 0 1 1 1 1 Pleckstrin homology domain VWA PF00092.28 EXF78035.1 - 2.8e-13 50.5 0.0 4.7e-13 49.8 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 EXF78035.1 - 2e-09 37.5 0.2 1e-08 35.3 0.2 2.1 1 1 0 1 1 1 1 von Willebrand factor type A domain zf-RING_2 PF13639.6 EXF78035.1 - 0.00086 19.6 5.7 0.0015 18.8 5.7 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 EXF78035.1 - 0.0078 16.2 5.4 0.013 15.4 5.4 1.4 1 0 0 1 1 1 1 zinc-RING finger domain PH PF00169.29 EXF78035.1 - 0.017 15.6 0.0 0.039 14.5 0.0 1.5 1 0 0 1 1 1 0 PH domain zf-C3HC4_2 PF13923.6 EXF78035.1 - 0.059 13.2 4.5 0.11 12.4 4.5 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 EXF78035.1 - 0.063 12.9 6.9 0.012 15.2 3.2 1.6 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type zf-rbx1 PF12678.7 EXF78035.1 - 0.066 13.5 2.6 0.14 12.4 2.6 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-RING-like PF08746.11 EXF78035.1 - 0.086 13.2 4.3 0.16 12.3 4.3 1.4 1 0 0 1 1 1 0 RING-like domain zf-RING_11 PF17123.5 EXF78035.1 - 0.1 12.3 4.2 0.21 11.4 4.2 1.5 1 0 0 1 1 1 0 RING-like zinc finger zf-C3HC4 PF00097.25 EXF78035.1 - 0.12 12.3 5.4 0.21 11.5 5.4 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF1147 PF06615.11 EXF78035.1 - 0.15 12.1 0.4 0.41 10.7 0.4 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1147) zf-C3H2C3 PF17122.5 EXF78035.1 - 4.2 7.5 4.9 8.7 6.5 4.9 1.6 1 0 0 1 1 1 0 Zinc-finger Topo_Zn_Ribbon PF08272.11 EXF78036.1 - 0.57 9.9 2.5 0.44 10.2 0.8 1.8 2 0 0 2 2 2 0 Topoisomerase I zinc-ribbon-like zf-CCHC_2 PF13696.6 EXF78038.1 - 8.7 6.3 9.5 18 5.3 2.6 2.5 2 0 0 2 2 2 0 Zinc knuckle MFS_1 PF07690.16 EXF78039.1 - 1.4e-30 106.4 26.0 3.8e-30 105.0 26.1 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily U3_snoRNA_assoc PF08297.11 EXF78040.1 - 1.1e-14 54.9 3.0 1.1e-14 54.9 3.0 4.4 3 1 0 3 3 3 1 U3 snoRNA associated TPR_12 PF13424.6 EXF78041.1 - 0.0019 18.5 1.7 0.0047 17.2 1.7 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.17 EXF78041.1 - 0.0043 17.1 5.4 0.062 13.4 0.1 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 EXF78041.1 - 0.0093 15.8 3.1 1.5 8.7 0.1 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_21 PF09976.9 EXF78041.1 - 0.019 14.7 2.0 0.031 14.0 0.5 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat-like domain TPR_8 PF13181.6 EXF78041.1 - 0.031 14.5 1.0 1.1 9.6 0.1 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat HRXXH PF13933.6 EXF78041.1 - 0.088 12.4 0.0 0.13 11.8 0.0 1.2 1 0 0 1 1 1 0 Putative peptidase family TPR_19 PF14559.6 EXF78041.1 - 0.16 12.5 1.4 1 9.9 0.7 2.3 1 1 1 2 2 2 0 Tetratricopeptide repeat Glyco_hydro_35 PF01301.19 EXF78042.1 - 1.8e-81 274.2 3.3 2.6e-81 273.7 3.3 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 BetaGal_dom4_5 PF13364.6 EXF78042.1 - 2.1e-61 205.5 2.6 2e-33 115.3 0.0 3.1 3 0 0 3 3 3 2 Beta-galactosidase jelly roll domain BetaGal_dom2 PF10435.9 EXF78042.1 - 5.2e-51 173.0 1.5 1.1e-50 172.0 1.5 1.6 1 0 0 1 1 1 1 Beta-galactosidase, domain 2 BetaGal_dom3 PF13363.6 EXF78042.1 - 8.4e-25 86.1 0.1 2.3e-23 81.5 0.0 2.7 3 0 0 3 3 3 1 Beta-galactosidase, domain 3 Glyco_hydro_42 PF02449.15 EXF78042.1 - 1.3e-05 24.8 0.0 0.00064 19.2 0.1 2.9 1 1 1 2 2 2 1 Beta-galactosidase Cellulase PF00150.18 EXF78042.1 - 8.8e-05 22.1 0.2 0.00078 19.0 0.0 2.5 2 1 0 2 2 2 1 Cellulase (glycosyl hydrolase family 5) Peptidase_M16_C PF05193.21 EXF78044.1 - 1.4e-18 67.6 0.0 5.3e-15 55.9 0.0 2.7 2 0 0 2 2 2 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EXF78044.1 - 1.2e-06 28.6 0.1 1.1e-05 25.4 0.0 2.3 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) M16C_assoc PF08367.11 EXF78044.1 - 0.00069 18.8 4.9 0.45 9.6 4.1 2.3 2 0 0 2 2 2 2 Peptidase M16C associated Sporozoite_P67 PF05642.11 EXF78044.1 - 0.41 8.7 2.9 0.6 8.1 2.9 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen RNA_pol_3_Rpc31 PF11705.8 EXF78044.1 - 1.2 9.4 16.8 0.17 12.1 11.1 2.1 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 Zw10 PF06248.13 EXF78045.1 - 1.2e-06 27.4 1.2 5.3e-05 22.0 1.8 2.7 2 1 0 2 2 2 1 Centromere/kinetochore Zw10 CorA PF01544.18 EXF78045.1 - 0.013 14.8 2.1 0.035 13.4 2.1 1.6 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Dsl1_C PF11989.8 EXF78045.1 - 0.027 14.2 0.0 0.065 12.9 0.0 1.6 1 0 0 1 1 1 0 Retrograde transport protein Dsl1 C terminal Com_YlbF PF06133.11 EXF78045.1 - 0.068 13.8 1.3 6.6 7.4 0.5 3.0 2 0 0 2 2 2 0 Control of competence regulator ComK, YlbF/YmcA CDC45 PF02724.14 EXF78045.1 - 0.18 10.1 6.3 0.36 9.1 6.3 1.4 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 EXF78045.1 - 0.55 8.4 13.3 0.86 7.7 13.3 1.2 1 0 0 1 1 1 0 Nop14-like family DHR10 PF18595.1 EXF78045.1 - 0.83 9.7 4.9 1.6 8.8 1.6 3.0 2 1 0 2 2 2 0 Designed helical repeat protein 10 domain SPX PF03105.19 EXF78047.1 - 0.0048 16.9 11.0 0.0078 16.2 11.0 1.3 1 0 0 1 1 1 1 SPX domain TMF_DNA_bd PF12329.8 EXF78047.1 - 0.062 13.3 3.6 8.1 6.5 2.1 2.9 2 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding DUF4201 PF13870.6 EXF78047.1 - 0.12 12.1 3.4 0.27 11.0 3.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4201) Lebercilin PF15619.6 EXF78047.1 - 0.3 10.7 8.3 0.082 12.6 2.9 2.3 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease DUF2968 PF11180.8 EXF78047.1 - 0.38 10.4 5.7 0.94 9.1 5.7 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) SRC-1 PF08832.10 EXF78047.1 - 4.1 8.5 10.3 3.5 8.7 1.2 2.9 2 0 0 2 2 2 0 Steroid receptor coactivator AKAP7_NLS PF10469.9 EXF78048.1 - 6.1e-35 121.0 0.0 7.2e-35 120.8 0.0 1.1 1 0 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain Hpt PF01627.23 EXF78049.1 - 4.4e-08 33.3 0.0 7.2e-08 32.6 0.0 1.4 1 1 0 1 1 1 1 Hpt domain Leptin PF02024.15 EXF78049.1 - 0.098 12.4 0.1 0.13 12.1 0.1 1.2 1 0 0 1 1 1 0 Leptin LAP1C PF05609.12 EXF78050.1 - 0.1 11.7 15.9 0.12 11.4 15.9 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Nucleoplasmin PF03066.15 EXF78050.1 - 0.1 13.1 0.8 0.2 12.2 0.8 1.5 1 0 0 1 1 1 0 Nucleoplasmin/nucleophosmin domain DUF966 PF06136.13 EXF78050.1 - 1.6 8.4 13.4 2.1 8.0 13.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Raftlin PF15250.6 EXF78050.1 - 3.3 6.4 13.3 5 5.8 13.3 1.4 1 0 0 1 1 1 0 Raftlin Nop25 PF09805.9 EXF78050.1 - 3.7 8.0 23.9 0.73 10.3 17.7 2.1 2 0 0 2 2 2 0 Nucleolar protein 12 (25kDa) COA2 PF17051.5 EXF78051.1 - 0.0002 21.4 0.0 0.00029 20.8 0.0 1.2 1 0 0 1 1 1 1 Cytochrome C oxidase assembly factor 2 Metallophos PF00149.28 EXF78052.1 - 7.2e-33 114.8 0.1 7.5e-23 82.1 0.0 2.1 1 1 0 2 2 2 2 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EXF78052.1 - 0.035 14.6 0.1 0.087 13.3 0.1 1.6 1 0 0 1 1 1 0 Serine-threonine protein phosphatase N-terminal domain DUF3584 PF12128.8 EXF78054.1 - 0.37 8.2 6.6 0.5 7.8 6.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) SIKE PF05769.11 EXF78054.1 - 0.45 10.4 5.5 0.66 9.9 5.5 1.1 1 0 0 1 1 1 0 SIKE family bZIP_1 PF00170.21 EXF78054.1 - 3.7 7.7 12.2 8.2 6.6 12.2 1.6 1 1 0 1 1 1 0 bZIP transcription factor AFG1_ATPase PF03969.16 EXF78056.1 - 5.7e-96 321.5 0.0 7.3e-92 308.0 0.0 2.1 2 0 0 2 2 2 2 AFG1-like ATPase AAA_16 PF13191.6 EXF78056.1 - 6.5e-05 23.4 0.5 0.13 12.7 0.0 3.1 2 1 1 3 3 3 2 AAA ATPase domain AAA_22 PF13401.6 EXF78056.1 - 0.00016 22.0 0.1 0.018 15.4 0.0 2.8 2 1 0 2 2 2 1 AAA domain Bac_DnaA PF00308.18 EXF78056.1 - 0.00022 21.1 0.2 0.41 10.4 0.1 2.6 2 1 0 2 2 2 2 Bacterial dnaA protein AAA_14 PF13173.6 EXF78056.1 - 0.002 18.1 0.0 0.0045 17.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 EXF78056.1 - 0.012 15.7 0.0 0.024 14.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA PF00004.29 EXF78056.1 - 0.053 13.9 0.0 0.15 12.5 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 EXF78056.1 - 0.12 12.7 0.0 0.43 11.0 0.0 2.1 1 1 0 1 1 1 0 RNA helicase NACHT PF05729.12 EXF78056.1 - 0.14 12.1 0.0 0.37 10.7 0.0 1.8 1 1 0 1 1 1 0 NACHT domain TsaE PF02367.17 EXF78056.1 - 0.16 12.0 0.0 0.33 10.9 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF1295 PF06966.12 EXF78057.1 - 9.3e-16 58.1 0.0 1.3e-15 57.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) ERG4_ERG24 PF01222.17 EXF78057.1 - 6.6e-07 28.4 0.2 1e-06 27.8 0.2 1.3 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family Steroid_dh PF02544.16 EXF78057.1 - 0.011 15.7 0.0 0.016 15.1 0.0 1.3 1 0 0 1 1 1 0 3-oxo-5-alpha-steroid 4-dehydrogenase MlaE PF02405.16 EXF78057.1 - 0.012 15.3 0.5 0.079 12.6 0.0 2.1 1 1 1 2 2 2 0 Permease MlaE Peptidase_M28 PF04389.17 EXF78058.1 - 2.2e-28 99.3 0.0 3.5e-28 98.6 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 EXF78058.1 - 1.6e-06 27.9 0.1 1.7e-05 24.6 0.1 2.3 2 1 0 2 2 2 1 Peptidase family M20/M25/M40 DSPc PF00782.20 EXF78059.1 - 6.2e-09 35.8 0.0 4.3e-07 29.8 0.0 2.2 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Init_tRNA_PT PF04179.12 EXF78059.1 - 0.074 13.4 0.0 0.12 12.6 0.0 1.5 1 0 0 1 1 1 0 Rit1 DUSP-like domain PhdYeFM_antitox PF02604.19 EXF78059.1 - 0.14 12.0 0.1 0.41 10.5 0.1 1.8 1 0 0 1 1 1 0 Antitoxin Phd_YefM, type II toxin-antitoxin system End3 PF12761.7 EXF78061.1 - 1.5e-75 253.8 0.3 1.9e-75 253.4 0.3 1.1 1 0 0 1 1 1 1 Actin cytoskeleton-regulatory complex protein END3 EF-hand_4 PF12763.7 EXF78061.1 - 7.3e-48 160.8 0.0 4.5e-47 158.3 0.0 2.0 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.32 EXF78061.1 - 3e-07 29.5 0.2 8.5e-07 28.1 0.2 1.8 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 EXF78061.1 - 3.1e-05 24.3 0.0 0.0001 22.6 0.0 2.0 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 EXF78061.1 - 0.00073 19.3 0.8 0.0028 17.5 0.2 2.3 2 0 0 2 2 2 1 EF-hand domain EF-hand_8 PF13833.6 EXF78061.1 - 0.00083 19.2 0.1 0.0016 18.2 0.1 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 EXF78061.1 - 0.03 13.8 2.1 0.062 12.8 0.1 2.5 2 0 0 2 2 2 0 EF hand CENP-F_leu_zip PF10473.9 EXF78061.1 - 0.067 13.2 3.6 6.7 6.7 0.0 2.2 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Pyr_redox_2 PF07992.14 EXF78062.1 - 3e-40 138.3 0.1 3.8e-40 138.0 0.1 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EXF78062.1 - 5e-11 43.0 0.5 1.2e-09 38.5 0.1 2.5 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EXF78062.1 - 0.00053 20.0 0.0 3.6 7.6 0.0 3.6 3 1 1 4 4 4 1 FAD-NAD(P)-binding K_oxygenase PF13434.6 EXF78062.1 - 0.0012 18.0 0.1 0.0082 15.3 0.0 2.1 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.6 EXF78062.1 - 0.0069 15.7 0.0 0.01 15.1 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EXF78062.1 - 0.0075 15.4 0.1 2.3 7.1 0.0 2.5 2 1 1 3 3 3 2 Lycopene cyclase protein RTP1_C2 PF10304.9 EXF78062.1 - 1.7 8.4 3.7 0.83 9.4 0.1 2.1 2 0 0 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 2 ACBP PF00887.19 EXF78063.1 - 3.8e-23 81.5 0.2 4.5e-23 81.3 0.2 1.1 1 0 0 1 1 1 1 Acyl CoA binding protein Imm71 PF15602.6 EXF78063.1 - 0.12 12.4 0.0 0.14 12.2 0.0 1.1 1 0 0 1 1 1 0 Immunity protein 71 ChaB PF06150.12 EXF78063.1 - 0.44 11.1 3.9 1.2 9.8 0.2 2.5 2 1 1 3 3 3 0 ChaB Tyr-DNA_phospho PF06087.12 EXF78064.1 - 7e-160 532.6 0.0 8.1e-160 532.4 0.0 1.0 1 0 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase PLDc_2 PF13091.6 EXF78064.1 - 0.0088 15.9 0.2 0.67 9.8 0.0 2.4 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.22 EXF78064.1 - 0.22 11.8 0.5 4 7.8 0.6 2.4 2 0 0 2 2 2 0 Phospholipase D Active site motif Ank_2 PF12796.7 EXF78065.1 - 6.8e-23 81.1 0.0 1.5e-08 35.1 0.0 4.8 2 1 3 5 5 5 4 Ankyrin repeats (3 copies) Ank PF00023.30 EXF78065.1 - 3.6e-18 65.1 0.2 2.5e-07 30.8 0.0 6.2 6 0 0 6 6 6 4 Ankyrin repeat Ank_4 PF13637.6 EXF78065.1 - 1.2e-17 64.0 5.1 2.9e-06 27.7 0.0 5.9 3 2 3 6 6 6 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EXF78065.1 - 3.1e-12 45.5 1.5 0.00024 21.3 0.0 7.3 7 0 0 7 7 7 2 Ankyrin repeat Ank_5 PF13857.6 EXF78065.1 - 5.9e-12 45.6 1.7 0.0098 16.2 0.0 5.5 4 1 2 6 6 6 4 Ankyrin repeats (many copies) Helo_like_N PF17111.5 EXF78065.1 - 0.00016 21.1 2.4 0.00059 19.3 2.4 2.0 1 1 0 1 1 1 1 Fungal N-terminal domain of STAND proteins SesA PF17107.5 EXF78065.1 - 0.14 12.4 0.2 0.39 10.9 0.2 1.8 1 0 0 1 1 1 0 N-terminal domain on NACHT_NTPase and P-loop NTPases DUF460 PF04312.13 EXF78065.1 - 0.18 11.5 0.0 0.38 10.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF460) Thioredoxin PF00085.20 EXF78066.1 - 4.5e-41 139.0 0.0 1.6e-23 82.6 0.0 3.5 3 1 0 3 3 3 2 Thioredoxin Thioredoxin_6 PF13848.6 EXF78066.1 - 7e-08 32.6 0.0 0.00069 19.6 0.0 3.7 1 1 2 3 3 3 1 Thioredoxin-like domain Thioredoxin_2 PF13098.6 EXF78066.1 - 0.00045 20.6 0.4 0.14 12.7 0.1 3.4 2 1 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 EXF78066.1 - 0.001 19.4 0.1 0.033 14.5 0.0 3.1 3 0 0 3 3 3 1 Thioredoxin-like Thioredoxin_7 PF13899.6 EXF78066.1 - 0.007 16.5 0.7 0.11 12.7 0.1 3.0 3 0 0 3 3 3 1 Thioredoxin-like HyaE PF07449.11 EXF78066.1 - 0.011 15.7 0.0 20 5.2 0.0 3.8 4 0 0 4 4 4 0 Hydrogenase-1 expression protein HyaE AhpC-TSA PF00578.21 EXF78066.1 - 0.018 14.9 0.5 0.12 12.3 0.0 2.5 2 0 0 2 2 2 0 AhpC/TSA family OST3_OST6 PF04756.13 EXF78066.1 - 0.086 12.2 0.0 3.7 6.8 0.0 2.8 3 0 0 3 3 3 0 OST3 / OST6 family, transporter family Presenilin PF01080.17 EXF78066.1 - 0.092 11.5 0.2 0.15 10.8 0.2 1.2 1 0 0 1 1 1 0 Presenilin Thioredoxin_3 PF13192.6 EXF78066.1 - 0.22 11.6 1.6 2.8 8.1 0.1 3.4 5 0 0 5 5 5 0 Thioredoxin domain TraF PF13728.6 EXF78066.1 - 0.23 11.2 0.1 0.23 11.2 0.1 3.9 2 1 1 3 3 2 0 F plasmid transfer operon protein Ndc1_Nup PF09531.10 EXF78066.1 - 6.2 5.4 6.5 9.4 4.8 6.5 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup PLDc_2 PF13091.6 EXF78067.1 - 3.7e-20 72.2 0.0 2.6e-06 27.4 0.0 3.8 3 1 0 3 3 3 3 PLD-like domain PLDc PF00614.22 EXF78067.1 - 1.1e-11 44.4 0.8 1.4e-05 25.0 0.0 2.5 2 0 0 2 2 2 2 Phospholipase D Active site motif GAGBD PF16828.5 EXF78067.1 - 0.07 13.2 0.0 0.15 12.2 0.0 1.5 1 0 0 1 1 1 0 GAG-binding domain on surface antigen Alg14 PF08660.11 EXF78067.1 - 0.2 11.5 0.0 2.2 8.2 0.0 2.2 2 0 0 2 2 2 0 Oligosaccharide biosynthesis protein Alg14 like Acetyltransf_1 PF00583.25 EXF78068.1 - 6.7e-09 36.0 0.0 8.6e-09 35.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EXF78068.1 - 2.1e-06 27.7 0.0 2.9e-06 27.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EXF78068.1 - 0.00037 20.4 0.0 0.00064 19.6 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_7 PF13508.7 EXF78068.1 - 0.0035 17.7 0.0 0.0054 17.1 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Pro_CA PF00484.19 EXF78069.1 - 8.6e-14 52.1 0.1 3e-13 50.3 0.1 1.8 1 1 0 1 1 1 1 Carbonic anhydrase DNA_topoisoIV PF00521.20 EXF78070.1 - 1.7e-124 416.0 0.6 5.2e-124 414.4 0.1 2.0 2 0 0 2 2 2 1 DNA gyrase/topoisomerase IV, subunit A TOPRIM_C PF16898.5 EXF78070.1 - 1.1e-48 164.7 3.2 6.9e-48 162.1 3.2 2.5 1 0 0 1 1 1 1 C-terminal associated domain of TOPRIM DNA_gyraseB PF00204.25 EXF78070.1 - 2.1e-25 89.2 2.4 5.7e-25 87.8 2.4 1.7 1 0 0 1 1 1 1 DNA gyrase B HATPase_c PF02518.26 EXF78070.1 - 1.1e-13 51.7 0.1 3e-13 50.3 0.1 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim PF01751.22 EXF78070.1 - 1.1e-06 28.7 0.0 5.5e-06 26.5 0.0 2.3 1 0 0 1 1 1 1 Toprim domain Reticulon PF02453.17 EXF78071.1 - 5.3e-34 117.4 2.5 7.4e-34 117.0 2.5 1.2 1 0 0 1 1 1 1 Reticulon RabGAP-TBC PF00566.18 EXF78072.1 - 1.5e-48 165.3 0.1 9.1e-48 162.7 0.0 2.2 2 0 0 2 2 2 1 Rab-GTPase-TBC domain zf-C4H2 PF10146.9 EXF78072.1 - 0.00021 21.7 2.5 0.00021 21.7 2.5 3.4 3 1 0 3 3 3 1 Zinc finger-containing protein Fez1 PF06818.15 EXF78072.1 - 0.0039 17.7 30.9 0.21 12.0 0.2 4.1 3 1 1 4 4 4 2 Fez1 DUF4686 PF15742.5 EXF78072.1 - 0.005 16.0 11.2 0.005 16.0 11.2 2.6 3 0 0 3 3 3 1 Domain of unknown function (DUF4686) Cnn_1N PF07989.11 EXF78072.1 - 0.037 14.2 19.1 3.2 8.0 0.0 4.5 3 1 1 4 4 4 0 Centrosomin N-terminal motif 1 Fib_alpha PF08702.10 EXF78072.1 - 0.047 13.9 9.5 0.029 14.6 2.5 2.8 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF1465 PF07323.12 EXF78072.1 - 0.23 11.3 7.4 4.8 7.0 2.3 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1465) FapA PF03961.13 EXF78072.1 - 1.4 7.4 6.9 1.2 7.7 1.8 2.3 2 0 0 2 2 2 0 Flagellar Assembly Protein A RNase_E_G PF10150.9 EXF78072.1 - 1.9 7.9 9.0 0.031 13.7 1.1 2.1 3 0 0 3 3 3 0 Ribonuclease E/G family SKA2 PF16740.5 EXF78072.1 - 1.9 8.3 16.7 8.7 6.2 7.7 2.8 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 2 Mod_r PF07200.13 EXF78072.1 - 2 8.5 23.1 0.014 15.5 5.5 3.7 3 0 0 3 3 3 0 Modifier of rudimentary (Mod(r)) protein Tmemb_cc2 PF10267.9 EXF78072.1 - 6.5 5.8 24.0 1.2 8.1 6.5 2.6 1 1 1 2 2 2 0 Predicted transmembrane and coiled-coil 2 protein SSXT PF05030.12 EXF78073.1 - 0.0015 18.1 1.0 0.0048 16.5 1.0 1.9 1 1 0 1 1 1 1 SSXT protein (N-terminal region) Lipase_GDSL PF00657.22 EXF78075.1 - 1.5e-09 38.1 0.0 2.3e-09 37.5 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.6 EXF78075.1 - 2.6e-06 27.9 1.2 1.1e-05 25.9 0.5 2.1 2 0 0 2 2 2 1 GDSL-like Lipase/Acylhydrolase family Aminotran_1_2 PF00155.21 EXF78076.1 - 1.1e-65 222.2 0.0 1.3e-65 221.9 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Glyco_hydro_76 PF03663.14 EXF78077.1 - 1.9e-125 419.2 10.0 2.1e-125 419.1 10.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 PMT PF02366.18 EXF78079.1 - 0.012 15.2 0.0 0.022 14.4 0.0 1.4 1 0 0 1 1 1 0 Dolichyl-phosphate-mannose-protein mannosyltransferase MAGE_N PF12440.8 EXF78079.1 - 0.3 11.8 15.6 0.64 10.7 15.6 1.5 1 0 0 1 1 1 0 Melanoma associated antigen family N terminal MscL PF01741.18 EXF78080.1 - 4.9e-21 75.3 0.2 6.1e-21 74.9 0.2 1.1 1 0 0 1 1 1 1 Large-conductance mechanosensitive channel, MscL zf-BED PF02892.15 EXF78080.1 - 0.0054 16.7 2.8 0.0086 16.1 2.8 1.3 1 0 0 1 1 1 1 BED zinc finger DZR PF12773.7 EXF78080.1 - 0.047 13.7 0.9 0.077 13.0 0.9 1.2 1 0 0 1 1 1 0 Double zinc ribbon C1_1 PF00130.22 EXF78080.1 - 0.06 13.2 2.5 0.093 12.6 2.5 1.3 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-C3HC4_3 PF13920.6 EXF78080.1 - 0.063 13.1 2.7 0.1 12.5 2.7 1.2 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF3043 PF11241.8 EXF78080.1 - 0.14 12.2 0.0 0.26 11.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3043) zinc_ribbon_2 PF13240.6 EXF78080.1 - 1.5 8.6 4.0 2.6 7.9 4.0 1.3 1 0 0 1 1 1 0 zinc-ribbon domain SUR7 PF06687.12 EXF78081.1 - 1.6e-27 96.5 1.0 1.9e-27 96.3 1.0 1.0 1 0 0 1 1 1 1 SUR7/PalI family Fig1 PF12351.8 EXF78081.1 - 3.9e-09 36.7 2.9 3.9e-09 36.7 2.9 1.7 2 0 0 2 2 2 1 Ca2+ regulator and membrane fusion protein Fig1 DUF2207 PF09972.9 EXF78081.1 - 0.41 9.4 3.2 0.26 10.0 0.6 1.9 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) PMP22_Claudin PF00822.20 EXF78081.1 - 2.2 8.1 8.2 0.85 9.5 3.4 2.1 2 0 0 2 2 2 0 PMP-22/EMP/MP20/Claudin family DUF2569 PF10754.9 EXF78081.1 - 2.9 8.3 13.0 3.3 8.1 1.0 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF2569) DUF92 PF01940.16 EXF78081.1 - 7.1 6.0 9.1 5.7 6.3 7.2 1.8 2 1 1 3 3 3 0 Integral membrane protein DUF92 ABC_tran PF00005.27 EXF78082.1 - 1.1e-45 155.6 0.0 6.2e-23 81.8 0.0 2.7 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EXF78082.1 - 6.8e-30 104.6 25.8 1.1e-25 90.8 9.9 2.5 2 0 0 2 2 2 2 ABC transporter transmembrane region AAA_21 PF13304.6 EXF78082.1 - 6.6e-12 45.8 5.9 0.13 12.0 0.5 4.3 2 2 1 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EXF78082.1 - 3.9e-10 39.6 0.0 0.0023 17.4 0.0 3.7 3 1 0 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EXF78082.1 - 9.2e-06 25.3 2.1 0.066 13.0 0.3 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_33 PF13671.6 EXF78082.1 - 1.7e-05 25.0 0.8 0.00059 20.0 0.0 3.0 3 0 0 3 3 3 1 AAA domain MMR_HSR1 PF01926.23 EXF78082.1 - 1.8e-05 24.8 0.4 0.11 12.6 0.2 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_16 PF13191.6 EXF78082.1 - 7.4e-05 23.2 0.3 0.44 10.9 0.2 2.9 2 0 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 EXF78082.1 - 0.00021 21.5 0.2 3.1 8.1 0.0 3.4 3 0 0 3 3 3 1 AAA domain AAA_7 PF12775.7 EXF78082.1 - 0.00024 20.7 0.1 0.06 12.9 0.0 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region RsgA_GTPase PF03193.16 EXF78082.1 - 0.0008 19.4 0.2 0.79 9.6 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase T2SSE PF00437.20 EXF78082.1 - 0.0029 16.7 0.7 0.45 9.5 0.0 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_23 PF13476.6 EXF78082.1 - 0.0036 17.8 0.1 1.8 9.0 0.0 2.4 2 0 0 2 2 2 1 AAA domain Dynamin_N PF00350.23 EXF78082.1 - 0.012 15.7 4.3 1.2 9.2 0.3 2.4 2 0 0 2 2 2 0 Dynamin family AAA_25 PF13481.6 EXF78082.1 - 0.026 14.1 1.8 4.5 6.8 0.1 3.1 3 0 0 3 3 3 0 AAA domain Zeta_toxin PF06414.12 EXF78082.1 - 0.045 13.0 0.3 1.8 7.8 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin SbcCD_C PF13558.6 EXF78082.1 - 0.063 13.5 2.9 7.7 6.8 0.1 3.4 3 1 0 3 3 2 0 Putative exonuclease SbcCD, C subunit AAA_PrkA PF08298.11 EXF78082.1 - 0.084 11.8 0.0 2 7.3 0.0 2.2 2 0 0 2 2 2 0 PrkA AAA domain AAA_15 PF13175.6 EXF78082.1 - 0.1 12.3 0.2 9.8 5.8 0.0 2.3 2 0 0 2 2 2 0 AAA ATPase domain NB-ARC PF00931.22 EXF78082.1 - 0.11 11.6 0.1 3.9 6.6 0.0 2.2 2 0 0 2 2 2 0 NB-ARC domain Mg_chelatase PF01078.21 EXF78082.1 - 0.12 11.8 0.2 3.4 7.0 0.0 2.3 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 EXF78082.1 - 0.12 12.9 0.0 12 6.4 0.0 2.4 2 0 0 2 2 2 0 AAA domain Roc PF08477.13 EXF78082.1 - 0.28 11.4 1.3 20 5.4 0.2 2.8 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase DUF87 PF01935.17 EXF78082.1 - 3.5 7.6 4.8 0.88 9.6 1.1 1.8 2 0 0 2 2 1 0 Helicase HerA, central domain cobW PF02492.19 EXF78082.1 - 4.1 6.9 5.2 20 4.7 0.4 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain NDT80_PhoG PF05224.12 EXF78084.1 - 2.4e-42 145.3 0.0 3.4e-42 144.8 0.0 1.2 1 0 0 1 1 1 1 NDT80 / PhoG like DNA-binding family Spc7_N PF15402.6 EXF78084.1 - 3.2 5.9 4.8 4.6 5.4 4.8 1.1 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 Helo_like_N PF17111.5 EXF78086.1 - 8.1e-82 273.6 11.3 2.1e-76 255.9 2.9 2.0 2 0 0 2 2 2 2 Fungal N-terminal domain of STAND proteins SesA PF17107.5 EXF78086.1 - 0.00048 20.3 1.4 0.0011 19.2 0.2 2.2 3 0 0 3 3 2 1 N-terminal domain on NACHT_NTPase and P-loop NTPases Rx_N PF18052.1 EXF78086.1 - 0.0011 19.2 0.6 0.3 11.4 0.0 3.3 3 0 0 3 3 3 1 Rx N-terminal domain Spectrin PF00435.21 EXF78086.1 - 0.021 15.3 4.3 1.2 9.7 0.0 3.0 3 0 0 3 3 3 0 Spectrin repeat DUF1664 PF07889.12 EXF78086.1 - 0.069 13.2 6.7 1.7 8.7 0.2 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) DUF2730 PF10805.8 EXF78086.1 - 0.11 12.6 1.6 1.5 8.9 0.1 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2730) TipAS PF07739.13 EXF78086.1 - 0.16 12.5 0.1 2.6 8.6 0.0 2.4 2 0 0 2 2 2 0 TipAS antibiotic-recognition domain Spore_YpjB PF09577.10 EXF78086.1 - 0.17 11.7 1.9 11 5.8 0.7 2.3 2 0 0 2 2 2 0 Sporulation protein YpjB (SpoYpjB) TMPIT PF07851.13 EXF78086.1 - 0.2 10.9 2.0 12 5.0 0.0 2.9 3 0 0 3 3 3 0 TMPIT-like protein WXG100 PF06013.12 EXF78086.1 - 0.21 11.8 1.2 17 5.7 0.4 2.9 2 0 0 2 2 2 0 Proteins of 100 residues with WXG Laminin_II PF06009.12 EXF78086.1 - 0.22 11.5 4.9 2.6 8.1 0.1 3.1 3 1 0 3 3 3 0 Laminin Domain II DUF1043 PF06295.12 EXF78086.1 - 0.22 11.5 4.1 4.6 7.3 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1043) DUF1690 PF07956.11 EXF78086.1 - 0.25 11.7 6.7 4.9 7.6 0.1 3.1 3 0 0 3 3 3 0 Protein of Unknown function (DUF1690) FAM184 PF15665.5 EXF78086.1 - 0.3 10.8 5.4 0.43 10.3 0.5 2.6 3 0 0 3 3 3 0 Family with sequence similarity 184, A and B ATG16 PF08614.11 EXF78086.1 - 0.39 10.9 7.7 6.2 7.0 0.3 2.7 2 1 0 2 2 2 0 Autophagy protein 16 (ATG16) NPV_P10 PF05531.12 EXF78086.1 - 0.39 11.2 7.4 2 8.9 1.4 3.2 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein Syntaxin-6_N PF09177.11 EXF78086.1 - 0.47 11.0 5.6 4.3 8.0 0.1 3.2 3 1 0 3 3 3 0 Syntaxin 6, N-terminal Syntaxin PF00804.25 EXF78086.1 - 0.67 9.6 4.3 11 5.7 0.1 2.9 3 0 0 3 3 3 0 Syntaxin LXG PF04740.12 EXF78086.1 - 0.88 9.2 5.8 3.8 7.2 0.1 2.8 3 0 0 3 3 3 0 LXG domain of WXG superfamily RasGAP_C PF03836.15 EXF78086.1 - 1.7 8.8 7.4 1 9.5 0.1 3.1 3 2 0 3 3 3 0 RasGAP C-terminus GAT PF03127.14 EXF78086.1 - 1.9 8.8 8.9 6.3 7.2 0.4 2.9 3 1 1 4 4 3 0 GAT domain Syntaxin_2 PF14523.6 EXF78086.1 - 2.8 8.4 7.6 1.3 9.4 0.3 3.1 3 1 0 3 3 3 0 Syntaxin-like protein CdvA PF18822.1 EXF78086.1 - 3.7 7.4 5.7 35 4.3 0.1 3.3 3 1 0 3 3 3 0 CdvA-like coiled-coil domain DUF3328 PF11807.8 EXF78087.1 - 5.1e-17 62.4 0.5 5.1e-17 62.4 0.5 3.1 2 1 0 3 3 3 2 Domain of unknown function (DUF3328) DUF3328 PF11807.8 EXF78088.1 - 0.0032 17.3 15.5 0.45 10.3 4.1 3.8 3 2 0 3 3 3 3 Domain of unknown function (DUF3328) DUF1648 PF07853.11 EXF78088.1 - 0.017 14.8 0.1 0.036 13.7 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1648) DUF3328 PF11807.8 EXF78089.1 - 0.081 12.7 0.6 1 9.1 1.3 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3328) Ribosomal_S28e PF01200.18 EXF78090.1 - 0.0022 17.9 2.6 20 5.3 0.1 4.1 1 1 3 4 4 4 1 Ribosomal protein S28e TT1725 PF18324.1 EXF78090.1 - 0.0087 16.1 0.0 0.31 11.2 0.0 2.0 1 1 1 2 2 2 1 Hypothetical protein TT1725 Dehydratase_LU PF02286.15 EXF78090.1 - 0.017 13.7 0.5 3 6.3 0.0 2.0 1 1 1 2 2 2 0 Dehydratase large subunit DUF5317 PF17248.2 EXF78090.1 - 0.097 12.7 1.8 19 5.2 0.4 2.9 1 1 1 3 3 3 0 Family of unknown function (DUF5317) BHD_2 PF10404.9 EXF78090.1 - 1.6 9.7 3.6 67 4.5 0.1 3.6 4 0 0 4 4 4 0 Rad4 beta-hairpin domain 2 ProQ_C PF17516.2 EXF78090.1 - 4.1 6.9 6.7 43 3.6 0.1 3.4 1 1 2 3 3 3 0 ProQ C-terminal domain Ank_2 PF12796.7 EXF78091.1 - 9.3e-62 205.6 8.9 1e-11 45.2 0.1 5.0 1 1 5 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EXF78091.1 - 8.9e-41 137.8 5.3 2.1e-09 37.7 0.0 5.7 3 2 4 7 7 7 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EXF78091.1 - 1e-35 117.7 3.5 0.003 17.9 0.0 8.1 8 0 0 8 8 8 7 Ankyrin repeat Ank PF00023.30 EXF78091.1 - 2.1e-31 107.0 14.4 0.00025 21.4 0.2 8.1 8 0 0 8 8 8 7 Ankyrin repeat Ank_5 PF13857.6 EXF78091.1 - 5.2e-17 61.7 9.0 0.00028 21.1 0.1 6.7 3 2 4 7 7 7 4 Ankyrin repeats (many copies) DAZAP2 PF11029.8 EXF78091.1 - 0.17 12.8 8.9 1.4 9.9 5.1 3.1 2 1 0 2 2 2 0 DAZ associated protein 2 (DAZAP2) DUF3328 PF11807.8 EXF78092.1 - 3e-21 76.2 0.0 4e-21 75.8 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) Aldedh PF00171.22 EXF78093.1 - 8.4e-156 519.1 0.2 9.5e-156 518.9 0.2 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 EXF78093.1 - 0.00081 18.9 0.0 0.0074 15.8 0.0 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF1487) Amidase PF01425.21 EXF78094.1 - 9.7e-93 311.6 0.0 1.1e-92 311.3 0.0 1.0 1 0 0 1 1 1 1 Amidase AA_permease_2 PF13520.6 EXF78095.1 - 4.3e-08 32.4 7.9 4.9e-08 32.2 7.9 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EXF78095.1 - 0.0012 17.5 5.6 0.0017 17.0 5.6 1.3 1 1 0 1 1 1 1 Amino acid permease Oxidored_FMN PF00724.20 EXF78096.1 - 1.9e-69 234.6 0.0 2.7e-69 234.1 0.0 1.2 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Fungal_trans PF04082.18 EXF78096.1 - 2.7e-12 46.3 0.1 4.8e-12 45.5 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Dus PF01207.17 EXF78096.1 - 0.087 11.9 1.2 0.23 10.5 0.0 2.2 2 1 1 3 3 3 0 Dihydrouridine synthase (Dus) LamB_YcsF PF03746.16 EXF78097.1 - 6.9e-80 268.2 0.0 7.8e-80 268.0 0.0 1.0 1 0 0 1 1 1 1 LamB/YcsF family DUF1989 PF09347.10 EXF78098.1 - 1.7e-36 125.4 0.0 2.3e-36 125.0 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1989) Sugar_tr PF00083.24 EXF78099.1 - 3.8e-44 151.3 11.6 4.1e-32 111.6 1.7 2.2 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 EXF78099.1 - 3.8e-17 62.3 19.2 7e-17 61.4 8.8 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF1345 PF07077.11 EXF78099.1 - 0.14 11.9 3.2 0.087 12.5 0.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1345) p450 PF00067.22 EXF78100.1 - 3.6e-50 171.1 0.0 4.4e-50 170.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 EXF78101.1 - 1.9e-42 145.6 0.1 2.3e-42 145.3 0.1 1.1 1 0 0 1 1 1 1 Cytochrome P450 HEAT_2 PF13646.6 EXF78101.1 - 0.084 13.3 0.3 0.27 11.7 0.3 1.9 1 0 0 1 1 1 0 HEAT repeats Fungal_trans PF04082.18 EXF78103.1 - 5.5e-14 51.8 1.1 8.5e-14 51.2 1.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF78103.1 - 6.6e-09 35.7 8.4 1.2e-08 34.9 8.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FAD_binding_3 PF01494.19 EXF78104.1 - 1.3e-21 77.2 0.0 1.7e-21 76.9 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 EXF78104.1 - 1.1e-06 28.4 0.3 0.035 13.7 0.0 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EXF78104.1 - 9.6e-05 21.7 0.0 0.12 11.6 0.0 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EXF78104.1 - 0.001 19.6 0.2 0.013 16.1 0.1 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EXF78104.1 - 0.054 13.7 0.1 0.16 12.2 0.1 1.9 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain ApbA PF02558.16 EXF78104.1 - 0.14 11.8 0.1 0.31 10.7 0.1 1.7 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Acetyltransf_18 PF18014.1 EXF78105.1 - 0.089 12.6 0.0 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Homeobox_KN PF05920.11 EXF78106.1 - 1.2e-16 60.3 1.3 5.4e-16 58.2 0.7 2.3 2 0 0 2 2 2 1 Homeobox KN domain Homeodomain PF00046.29 EXF78106.1 - 0.00017 21.3 0.1 0.00041 20.1 0.1 1.6 1 0 0 1 1 1 1 Homeodomain HTH_Tnp_Tc5 PF03221.16 EXF78106.1 - 0.0013 18.8 0.3 0.039 14.0 0.1 3.2 3 0 0 3 3 3 1 Tc5 transposase DNA-binding domain zf-C2H2_4 PF13894.6 EXF78106.1 - 0.0023 18.6 3.5 0.0023 18.6 3.5 4.8 4 0 0 4 4 4 2 C2H2-type zinc finger zf-C2H2 PF00096.26 EXF78106.1 - 0.02 15.3 23.1 0.022 15.2 3.9 4.1 4 0 0 4 4 4 0 Zinc finger, C2H2 type zf-met PF12874.7 EXF78106.1 - 1.6 9.2 7.7 18 5.9 0.3 4.0 4 0 0 4 4 4 0 Zinc-finger of C2H2 type Zn_clus PF00172.18 EXF78106.1 - 1.8 8.7 4.8 0.3 11.2 0.6 1.9 2 0 0 2 2 2 0 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.16 EXF78107.1 - 2e-11 43.4 23.3 2.4e-11 43.2 23.3 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF78107.1 - 0.36 9.6 11.5 0.057 12.3 3.9 2.0 1 1 1 2 2 2 0 Sugar (and other) transporter Methyltransf_2 PF00891.18 EXF78109.1 - 6.4e-24 84.4 0.0 8.9e-24 83.9 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain DUF3662 PF12401.8 EXF78109.1 - 0.046 14.1 0.0 0.08 13.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2662) Abhydrolase_6 PF12697.7 EXF78110.1 - 0.00041 21.0 1.1 0.00041 21.0 1.1 1.8 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EXF78110.1 - 0.029 14.0 0.2 0.092 12.4 0.0 1.9 2 1 0 2 2 2 0 alpha/beta hydrolase fold DUF1749 PF08538.10 EXF78110.1 - 0.049 12.7 0.0 0.075 12.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1749) Defensin_2 PF01097.18 EXF78114.1 - 0.14 12.1 2.8 0.2 11.6 2.8 1.3 1 0 0 1 1 1 0 Arthropod defensin SNARE_assoc PF09335.11 EXF78115.1 - 3.5e-20 72.7 8.7 1.8e-19 70.3 7.5 2.2 2 0 0 2 2 2 1 SNARE associated Golgi protein DUF2142 PF09913.9 EXF78115.1 - 0.0016 17.4 0.6 0.003 16.5 0.2 1.6 2 0 0 2 2 2 1 Predicted membrane protein (DUF2142) Phage_holin_3_6 PF07332.11 EXF78115.1 - 0.02 14.9 9.8 0.32 11.1 2.2 2.8 2 2 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III DUF3671 PF12420.8 EXF78115.1 - 0.058 13.5 4.4 5.7 7.0 1.8 2.3 2 0 0 2 2 2 0 Protein of unknown function SIT PF15330.6 EXF78115.1 - 0.069 13.6 0.2 0.16 12.4 0.2 1.6 1 0 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT DUF5305 PF17231.2 EXF78115.1 - 0.098 12.0 0.4 0.85 9.0 0.3 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5305) ESSS PF10183.9 EXF78115.1 - 0.25 11.6 0.8 1.4 9.2 0.0 2.6 3 0 0 3 3 3 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) SieB PF14163.6 EXF78115.1 - 0.82 9.2 12.4 1.6 8.2 0.4 3.4 1 1 3 4 4 4 0 Super-infection exclusion protein B AhpC-TSA_2 PF13911.6 EXF78116.1 - 3.8e-17 62.4 0.0 1.2e-16 60.8 0.0 1.8 2 0 0 2 2 2 1 AhpC/TSA antioxidant enzyme AhpC-TSA PF00578.21 EXF78116.1 - 0.013 15.5 0.0 0.041 13.8 0.0 1.8 1 1 0 1 1 1 0 AhpC/TSA family IBR PF01485.21 EXF78118.1 - 6e-09 36.0 10.7 1.7e-05 25.0 2.1 3.5 4 0 0 4 4 4 2 IBR domain, a half RING-finger domain Peptidase_M24 PF00557.24 EXF78120.1 - 1.1e-44 152.7 0.1 1.4e-44 152.3 0.1 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 Ribosomal_60s PF00428.19 EXF78120.1 - 0.23 12.1 4.8 0.63 10.7 4.8 1.8 1 0 0 1 1 1 0 60s Acidic ribosomal protein SPT6_acidic PF14632.6 EXF78120.1 - 1.7 9.3 8.1 0.07 13.7 1.3 1.9 2 0 0 2 2 2 0 Acidic N-terminal SPT6 PRELI PF04707.14 EXF78121.1 - 4.7e-39 133.7 0.0 5.6e-39 133.5 0.0 1.1 1 0 0 1 1 1 1 PRELI-like family SQS_PSY PF00494.19 EXF78122.1 - 0.057 12.9 0.9 0.079 12.5 0.9 1.1 1 0 0 1 1 1 0 Squalene/phytoene synthase PRK PF00485.18 EXF78123.1 - 9e-06 25.6 0.0 2.6e-05 24.0 0.0 1.7 1 1 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family NB-ARC PF00931.22 EXF78123.1 - 3.8e-05 23.0 0.0 5.6e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 NB-ARC domain AAA_18 PF13238.6 EXF78123.1 - 0.00016 22.2 0.1 0.00082 19.9 0.1 2.0 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 EXF78123.1 - 0.0023 17.3 0.1 0.0044 16.3 0.0 1.5 2 0 0 2 2 2 1 Zeta toxin Thymidylate_kin PF02223.17 EXF78123.1 - 0.005 16.5 0.1 0.21 11.2 0.0 2.2 2 0 0 2 2 2 1 Thymidylate kinase T2SSE PF00437.20 EXF78123.1 - 0.0064 15.6 0.1 0.038 13.1 0.0 1.9 2 0 0 2 2 2 1 Type II/IV secretion system protein MeaB PF03308.16 EXF78123.1 - 0.0088 15.1 0.0 0.014 14.4 0.0 1.2 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB RuvB_N PF05496.12 EXF78123.1 - 0.015 15.0 0.0 0.026 14.3 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 EXF78123.1 - 0.026 14.7 0.1 0.21 11.8 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.6 EXF78123.1 - 0.028 14.9 0.2 0.7 10.3 0.0 2.5 2 1 0 2 2 2 0 AAA domain AAA_22 PF13401.6 EXF78123.1 - 0.029 14.6 0.0 0.05 13.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EXF78123.1 - 0.061 13.7 0.1 0.076 13.4 0.1 1.4 1 1 0 1 1 1 0 AAA ATPase domain AAA PF00004.29 EXF78123.1 - 0.12 12.8 0.0 0.2 12.1 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) SKI PF01202.22 EXF78123.1 - 0.13 12.3 0.0 2.7 8.1 0.0 2.2 2 0 0 2 2 2 0 Shikimate kinase Viral_helicase1 PF01443.18 EXF78123.1 - 0.17 11.6 0.0 0.24 11.1 0.0 1.2 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase cobW PF02492.19 EXF78123.1 - 0.23 11.0 0.3 0.35 10.4 0.3 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain DUF4711 PF15829.5 EXF78124.1 - 0.62 10.0 4.1 0.24 11.3 0.5 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4711) Tubulin PF00091.25 EXF78126.1 - 3.1e-67 226.6 0.0 4.7e-67 226.0 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EXF78126.1 - 8.2e-46 155.3 0.3 1.5e-45 154.4 0.0 1.6 2 0 0 2 2 2 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 EXF78126.1 - 1.7e-07 31.5 0.0 3.5e-07 30.5 0.0 1.5 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain PLDc PF00614.22 EXF78127.1 - 1.9e-16 59.4 0.4 1.5e-07 31.3 0.2 2.8 2 0 0 2 2 2 2 Phospholipase D Active site motif PLDc_2 PF13091.6 EXF78127.1 - 4.4e-13 49.3 0.0 4.5e-07 29.8 0.0 2.6 2 0 0 2 2 2 2 PLD-like domain PX PF00787.24 EXF78127.1 - 1.3e-06 28.3 0.2 1.9e-05 24.6 0.0 2.9 3 1 0 3 3 3 1 PX domain PH_2 PF08458.10 EXF78127.1 - 0.041 14.2 0.6 0.083 13.3 0.6 1.5 1 0 0 1 1 1 0 Plant pleckstrin homology-like region DUF4028 PF13220.6 EXF78127.1 - 0.067 13.0 0.1 3.1 7.6 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF4028) COQ7 PF03232.13 EXF78128.1 - 1.1e-70 236.9 0.3 1.3e-70 236.7 0.3 1.1 1 0 0 1 1 1 1 Ubiquinone biosynthesis protein COQ7 Rubrerythrin PF02915.17 EXF78128.1 - 0.0027 18.1 0.0 0.009 16.4 0.0 1.8 1 1 0 1 1 1 1 Rubrerythrin Vitellogenin_N PF01347.22 EXF78128.1 - 0.019 13.4 0.0 0.073 11.5 0.0 1.6 1 1 0 2 2 2 0 Lipoprotein amino terminal region Plus-3 PF03126.18 EXF78129.1 - 6.3e-30 103.9 0.0 2.1e-29 102.2 0.0 2.0 1 0 0 1 1 1 1 Plus-3 domain GDPD PF03009.17 EXF78130.1 - 1.6e-32 113.2 0.0 2.7e-32 112.5 0.0 1.3 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family GDPD_2 PF13653.6 EXF78130.1 - 5.3e-06 26.7 0.9 1.5e-05 25.3 0.9 1.9 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family Peptidase_U32 PF01136.19 EXF78130.1 - 0.014 14.5 0.0 0.078 12.1 0.0 1.9 2 0 0 2 2 2 0 Peptidase family U32 Fungal_trans PF04082.18 EXF78131.1 - 1.4e-29 102.9 0.1 1.4e-29 102.9 0.1 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF78131.1 - 7.2e-10 38.8 11.5 1.4e-09 37.9 11.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain bZIP_1 PF00170.21 EXF78131.1 - 0.084 13.0 0.4 0.32 11.1 0.4 2.1 1 0 0 1 1 1 0 bZIP transcription factor Trimer_CC PF08954.11 EXF78131.1 - 0.1 12.2 1.9 0.37 10.4 1.9 2.0 1 0 0 1 1 1 0 Trimerisation motif HrpB7 PF09486.10 EXF78131.1 - 1.9 8.9 6.2 2.4 8.5 0.1 2.9 3 0 0 3 3 3 0 Bacterial type III secretion protein (HrpB7) TFIIA PF03153.13 EXF78131.1 - 7.6 6.4 16.9 15 5.4 16.9 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SET PF00856.28 EXF78132.1 - 0.0012 19.3 0.0 0.0035 17.7 0.0 1.9 2 1 0 2 2 2 1 SET domain Pkinase PF00069.25 EXF78134.1 - 1.2e-10 41.2 0.0 2.2e-10 40.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain HEAT PF02985.22 EXF78134.1 - 1.5e-09 37.3 0.1 0.034 14.4 0.0 5.0 4 0 0 4 4 4 3 HEAT repeat HEAT_2 PF13646.6 EXF78134.1 - 1.1e-05 25.7 0.2 0.0094 16.3 0.0 3.4 2 1 2 4 4 4 2 HEAT repeats Pkinase_Tyr PF07714.17 EXF78134.1 - 2.8e-05 23.5 0.0 5e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Cnd1 PF12717.7 EXF78134.1 - 3e-05 24.1 0.0 0.00011 22.3 0.0 1.7 1 1 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 EXF78134.1 - 0.0019 18.7 0.2 5.1 7.7 0.0 3.6 3 1 1 4 4 4 2 HEAT-like repeat WD40 PF00400.32 EXF78135.1 - 3e-40 135.5 14.8 5.7e-10 39.6 0.0 8.0 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EXF78135.1 - 2e-14 53.7 0.7 0.011 16.0 0.0 4.8 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EXF78135.1 - 2.7e-08 33.2 0.1 0.21 10.5 0.0 4.6 2 1 2 4 4 4 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 EXF78135.1 - 5.7e-06 25.2 3.0 0.084 11.5 0.1 4.5 3 1 0 3 3 3 2 Nucleoporin Nup120/160 PALB2_WD40 PF16756.5 EXF78135.1 - 5.2e-05 22.3 4.7 5.6e-05 22.2 0.1 3.0 3 1 1 4 4 4 1 Partner and localizer of BRCA2 WD40 domain Frtz PF11768.8 EXF78135.1 - 0.00027 19.4 0.0 0.0012 17.3 0.0 2.0 2 1 1 3 3 3 1 WD repeat-containing and planar cell polarity effector protein Fritz HPS3_N PF14761.6 EXF78135.1 - 0.001 18.6 0.0 0.025 14.1 0.0 2.5 2 1 1 3 3 3 1 Hermansky-Pudlak syndrome 3 Coatomer_WDAD PF04053.14 EXF78135.1 - 0.0013 17.9 0.0 0.0018 17.4 0.0 1.2 1 0 0 1 1 1 1 Coatomer WD associated region DUF1513 PF07433.11 EXF78135.1 - 0.0075 15.4 0.6 2.6 7.1 0.0 3.2 1 1 2 4 4 4 1 Protein of unknown function (DUF1513) Hira PF07569.11 EXF78135.1 - 0.12 12.1 0.8 10 5.8 0.6 3.1 1 1 1 2 2 2 0 TUP1-like enhancer of split Nucleoporin_N PF08801.11 EXF78135.1 - 0.13 11.0 0.3 2.8 6.6 0.0 2.8 3 1 0 3 3 3 0 Nup133 N terminal like DUF3328 PF11807.8 EXF78136.1 - 1.1e-21 77.6 0.0 1.5e-21 77.2 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) ketoacyl-synt PF00109.26 EXF78137.1 - 2.2e-59 201.1 0.6 4.3e-59 200.2 0.6 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 EXF78137.1 - 4.2e-39 134.9 1.0 8.4e-39 133.9 1.0 1.5 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EXF78137.1 - 4.3e-31 107.4 0.0 9.3e-31 106.3 0.0 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Thioesterase PF00975.20 EXF78137.1 - 6.2e-24 85.4 0.7 1.4e-22 80.9 0.2 3.0 2 1 0 2 2 2 1 Thioesterase domain PS-DH PF14765.6 EXF78137.1 - 4.4e-21 75.4 0.1 7.4e-21 74.7 0.1 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase PP-binding PF00550.25 EXF78137.1 - 2.7e-10 40.5 0.7 6.6e-10 39.2 0.7 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site SAT PF16073.5 EXF78137.1 - 3.7e-06 26.8 0.0 3.8e-05 23.5 0.0 2.3 2 0 0 2 2 2 1 Starter unit:ACP transacylase in aflatoxin biosynthesis KAsynt_C_assoc PF16197.5 EXF78137.1 - 8.3e-05 23.0 0.0 0.0002 21.8 0.0 1.7 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Thiolase_N PF00108.23 EXF78137.1 - 0.0026 17.2 0.2 0.0062 15.9 0.2 1.5 1 0 0 1 1 1 1 Thiolase, N-terminal domain FHA PF00498.26 EXF78138.1 - 1e-10 41.8 0.0 2e-10 40.8 0.0 1.6 1 0 0 1 1 1 1 FHA domain IFRD PF05004.13 EXF78139.1 - 1.2e-69 234.7 4.0 1.6e-69 234.4 4.0 1.2 1 0 0 1 1 1 1 Interferon-related developmental regulator (IFRD) HEAT_EZ PF13513.6 EXF78139.1 - 2.3e-06 28.0 0.1 0.00088 19.7 0.0 4.3 5 0 0 5 5 5 1 HEAT-like repeat HEAT_2 PF13646.6 EXF78139.1 - 0.0024 18.2 0.1 0.074 13.5 0.0 3.0 2 1 0 2 2 2 1 HEAT repeats HEAT PF02985.22 EXF78139.1 - 0.031 14.5 0.0 1.3 9.5 0.0 3.1 3 0 0 3 3 3 0 HEAT repeat POX PF07526.11 EXF78139.1 - 0.042 14.4 1.3 0.27 11.8 0.5 2.3 2 0 0 2 2 2 0 Associated with HOX Adaptin_N PF01602.20 EXF78139.1 - 0.15 10.6 0.0 0.44 9.0 0.0 1.7 1 1 0 1 1 1 0 Adaptin N terminal region Arm PF00514.23 EXF78139.1 - 0.15 12.1 0.1 7.2 6.8 0.0 2.8 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat MMR_HSR1_C PF08438.10 EXF78141.1 - 2.6e-37 127.8 0.0 4.7e-37 127.0 0.0 1.4 1 0 0 1 1 1 1 GTPase of unknown function C-terminal MMR_HSR1 PF01926.23 EXF78141.1 - 3.5e-10 40.0 0.0 1e-09 38.4 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EXF78141.1 - 0.084 12.8 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase Pmp3 PF01679.17 EXF78143.1 - 1.3e-24 86.2 7.5 1.4e-24 86.0 7.5 1.0 1 0 0 1 1 1 1 Proteolipid membrane potential modulator PIG-F PF06699.11 EXF78145.1 - 4.2e-64 216.0 4.0 5e-64 215.8 4.0 1.0 1 0 0 1 1 1 1 GPI biosynthesis protein family Pig-F PsbI PF02532.14 EXF78145.1 - 0.043 13.8 0.1 0.043 13.8 0.1 2.3 2 1 1 3 3 3 0 Photosystem II reaction centre I protein (PSII 4.8 kDa protein) Actin PF00022.19 EXF78147.1 - 5.6e-128 427.0 0.0 2.3e-127 425.0 0.0 1.7 1 1 0 1 1 1 1 Actin DUF3602 PF12223.8 EXF78148.1 - 2.2e-19 69.8 7.1 3.2e-14 53.3 3.5 2.4 1 1 1 2 2 2 2 Protein of unknown function (DUF3602) HET PF06985.11 EXF78149.1 - 8.1e-26 91.1 0.0 1.4e-25 90.3 0.0 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Aconitase PF00330.20 EXF78150.1 - 9e-148 493.1 0.0 1.2e-147 492.7 0.0 1.2 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 EXF78150.1 - 5.7e-38 130.2 0.0 9.5e-38 129.5 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain DUF521 PF04412.13 EXF78150.1 - 0.014 14.1 0.0 0.022 13.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF521) COPIIcoated_ERV PF07970.12 EXF78151.1 - 7.3e-37 127.4 0.1 1.4e-36 126.5 0.1 1.4 1 1 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 EXF78151.1 - 2.3e-25 88.8 0.0 4.1e-25 87.9 0.0 1.4 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) N_BRCA1_IG PF16158.5 EXF78152.1 - 6.2e-35 120.0 0.0 2.5e-34 118.1 0.0 2.1 2 0 0 2 2 2 1 Ig-like domain from next to BRCA1 gene ZZ PF00569.17 EXF78152.1 - 9.9e-18 63.7 62.9 4.2e-06 26.5 8.4 4.4 4 0 0 4 4 4 4 Zinc finger, ZZ type C1_2 PF03107.16 EXF78152.1 - 0.0045 17.3 51.7 0.11 12.8 10.6 4.5 4 0 0 4 4 4 3 C1 domain Btz PF09405.10 EXF78153.1 - 7.2e-27 94.2 1.8 1.8e-26 92.9 1.8 1.7 1 0 0 1 1 1 1 CASC3/Barentsz eIF4AIII binding Asp PF00026.23 EXF78154.1 - 4.7e-69 233.2 2.0 6.2e-69 232.8 2.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EXF78154.1 - 2.4e-15 57.2 4.6 4.4e-10 40.1 0.0 2.8 2 1 1 3 3 3 2 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EXF78154.1 - 0.00049 20.7 0.9 0.73 10.5 0.2 3.0 2 1 0 2 2 2 2 Aspartyl protease Aminotran_4 PF01063.19 EXF78155.1 - 8.5e-22 78.1 0.0 1.6e-21 77.2 0.0 1.3 1 0 0 1 1 1 1 Amino-transferase class IV TPR_1 PF00515.28 EXF78156.1 - 3.2e-47 156.5 21.7 3.4e-06 26.6 0.0 11.4 11 0 0 11 11 11 10 Tetratricopeptide repeat TPR_2 PF07719.17 EXF78156.1 - 3e-44 145.6 16.3 0.00015 21.6 0.0 11.4 11 0 0 11 11 11 10 Tetratricopeptide repeat TPR_11 PF13414.6 EXF78156.1 - 8e-26 89.5 16.9 2e-05 24.2 0.0 8.6 5 2 3 8 8 8 7 TPR repeat TPR_8 PF13181.6 EXF78156.1 - 1.5e-24 84.1 20.0 0.0046 17.1 0.0 11.2 11 0 0 11 11 11 6 Tetratricopeptide repeat TPR_17 PF13431.6 EXF78156.1 - 5.6e-23 79.6 7.2 7.1e-05 22.9 0.0 9.1 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_16 PF13432.6 EXF78156.1 - 1.1e-22 80.4 11.3 0.00022 21.8 0.1 7.3 6 2 1 8 8 7 5 Tetratricopeptide repeat TPR_12 PF13424.6 EXF78156.1 - 1.9e-20 72.9 22.4 0.00084 19.6 1.7 9.3 3 3 6 9 9 9 8 Tetratricopeptide repeat TPR_19 PF14559.6 EXF78156.1 - 1.9e-15 57.1 17.0 2.6e-05 24.6 1.0 6.8 6 1 0 6 6 6 3 Tetratricopeptide repeat TPR_9 PF13371.6 EXF78156.1 - 1.6e-13 50.6 5.7 1.1e-05 25.5 0.0 5.7 5 2 2 7 7 6 2 Tetratricopeptide repeat TPR_14 PF13428.6 EXF78156.1 - 4.1e-11 42.7 21.0 0.027 15.3 0.6 9.5 4 3 8 12 12 10 3 Tetratricopeptide repeat TPR_7 PF13176.6 EXF78156.1 - 4.7e-11 41.9 16.6 0.022 14.7 0.1 9.5 9 1 1 10 10 10 2 Tetratricopeptide repeat SHNi-TPR PF10516.9 EXF78156.1 - 1.8e-08 33.7 1.9 0.1 12.0 0.0 5.6 5 0 0 5 5 5 2 SHNi-TPR TPR_MalT PF17874.1 EXF78156.1 - 3.9e-08 33.0 0.8 1.6e-07 31.0 0.8 2.0 1 1 0 1 1 1 1 MalT-like TPR region ANAPC3 PF12895.7 EXF78156.1 - 9.1e-08 32.2 9.8 0.2 11.9 0.2 5.9 2 2 3 6 6 6 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.6 EXF78156.1 - 2.6e-07 30.3 17.5 0.03 14.2 0.4 8.8 9 0 0 9 9 8 1 Tetratricopeptide repeat TPR_15 PF13429.6 EXF78156.1 - 6e-07 29.0 1.7 0.079 12.2 0.3 4.4 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.6 EXF78156.1 - 9.8e-06 25.9 16.2 13 6.7 0.0 8.8 10 0 0 10 10 8 0 Tetratricopeptide repeat DUF3856 PF12968.7 EXF78156.1 - 0.003 17.6 5.7 5.5 7.1 0.0 6.0 4 1 2 6 6 6 1 Domain of Unknown Function (DUF3856) TPR_4 PF07721.14 EXF78156.1 - 0.019 15.6 0.1 1e+02 4.0 0.0 4.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TAF1_subA PF14929.6 EXF78156.1 - 0.028 13.9 2.0 0.097 12.1 0.2 2.3 2 1 1 3 3 3 0 TAF RNA Polymerase I subunit A MAS20 PF02064.15 EXF78156.1 - 0.04 14.0 10.9 0.53 10.4 0.8 4.4 4 1 1 5 5 4 0 MAS20 protein import receptor MIT PF04212.18 EXF78156.1 - 0.057 13.5 13.9 13 5.9 0.1 5.9 7 0 0 7 7 6 0 MIT (microtubule interacting and transport) domain Sel1 PF08238.12 EXF78156.1 - 0.073 13.8 6.7 1.8 9.4 0.1 4.7 5 0 0 5 5 3 0 Sel1 repeat HrpB1_HrpK PF09613.10 EXF78156.1 - 0.08 12.6 0.3 0.68 9.6 0.2 2.2 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB1_HrpK) Foie-gras_1 PF11817.8 EXF78156.1 - 0.23 11.0 2.9 0.28 10.7 0.3 2.3 3 0 0 3 3 2 0 Foie gras liver health family 1 TPR_3 PF07720.12 EXF78156.1 - 0.47 10.5 14.5 0.41 10.7 0.3 5.5 6 0 0 6 6 6 0 Tetratricopeptide repeat NARP1 PF12569.8 EXF78156.1 - 0.88 8.4 24.7 0.3 9.9 0.3 4.8 3 2 1 5 5 5 0 NMDA receptor-regulated protein 1 Syntaxin PF00804.25 EXF78157.1 - 2.5e-26 92.6 9.5 2.5e-26 92.6 9.5 1.8 2 0 0 2 2 2 1 Syntaxin SNARE PF05739.19 EXF78157.1 - 1.2e-10 41.2 0.3 1.2e-10 41.2 0.3 2.3 3 0 0 3 3 2 1 SNARE domain Syntaxin_2 PF14523.6 EXF78157.1 - 2.4e-05 24.6 14.3 0.00019 21.7 5.4 2.4 2 0 0 2 2 2 2 Syntaxin-like protein Fer4_24 PF18109.1 EXF78157.1 - 0.0047 17.2 0.9 0.011 16.0 0.1 2.1 2 0 0 2 2 1 1 Ferredoxin I 4Fe-4S cluster domain MCU PF04678.13 EXF78157.1 - 0.0049 17.0 7.2 0.005 17.0 1.5 2.2 2 0 0 2 2 2 1 Mitochondrial calcium uniporter FUSC PF04632.12 EXF78157.1 - 0.0064 15.1 9.6 0.026 13.1 1.2 2.1 1 1 0 2 2 2 2 Fusaric acid resistance protein family ETRAMP PF09716.10 EXF78157.1 - 0.021 14.9 0.0 0.028 14.5 0.0 1.5 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) IZUMO PF15005.6 EXF78157.1 - 0.044 14.3 3.3 1.2 9.7 0.1 2.3 2 0 0 2 2 2 0 Izumo sperm-egg fusion, Ig domain-associated Holin_2-3 PF13272.6 EXF78157.1 - 0.099 12.9 0.1 0.19 12.0 0.1 1.5 1 0 0 1 1 1 0 Putative 2/3 transmembrane domain holin DotU PF09850.9 EXF78157.1 - 0.13 12.0 2.1 0.15 11.7 0.2 2.1 2 0 0 2 2 2 0 Type VI secretion system protein DotU DUF2207 PF09972.9 EXF78157.1 - 0.26 10.0 4.7 0.36 9.5 0.0 2.0 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) Use1 PF09753.9 EXF78157.1 - 0.27 10.9 12.9 0.57 9.9 12.9 1.6 1 1 0 1 1 1 0 Membrane fusion protein Use1 Mod_r PF07200.13 EXF78157.1 - 0.3 11.2 15.9 1 9.4 6.6 2.7 2 1 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein Allexi_40kDa PF05549.11 EXF78157.1 - 0.9 9.0 8.7 1.2 8.6 1.4 2.1 2 0 0 2 2 2 0 Allexivirus 40kDa protein Spc42p PF11544.8 EXF78157.1 - 0.98 9.5 5.5 0.32 11.0 1.4 2.3 2 0 0 2 2 2 0 Spindle pole body component Spc42p PBC PF03792.13 EXF78157.1 - 1.6 8.4 9.8 0.13 12.0 2.3 2.3 1 1 1 2 2 2 0 PBC domain SKA1 PF07160.12 EXF78157.1 - 3.3 7.5 13.4 0.24 11.2 3.3 2.3 1 1 2 3 3 3 0 Spindle and kinetochore-associated protein 1 JIP_LZII PF16471.5 EXF78157.1 - 4.7 7.5 10.4 11 6.2 0.0 3.8 4 1 0 4 4 4 0 JNK-interacting protein leucine zipper II Baculo_PEP_C PF04513.12 EXF78157.1 - 5.6 7.0 13.0 7.3 6.6 3.7 3.0 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus CTNNBL PF08216.11 EXF78158.1 - 0.0042 17.2 0.0 0.0072 16.5 0.0 1.4 1 0 0 1 1 1 1 Catenin-beta-like, Arm-motif containing nuclear Brix PF04427.18 EXF78158.1 - 0.013 15.6 0.0 0.015 15.4 0.0 1.3 1 0 0 1 1 1 0 Brix domain UPF1_Zn_bind PF09416.10 EXF78159.1 - 8e-71 236.9 2.7 2.7e-70 235.2 1.2 2.2 2 0 0 2 2 2 1 RNA helicase (UPF2 interacting domain) AAA_12 PF13087.6 EXF78159.1 - 3.2e-60 203.2 0.0 6.4e-60 202.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 EXF78159.1 - 1.8e-53 182.0 2.7 1.2e-30 107.2 0.2 2.4 1 1 1 2 2 2 2 AAA domain DUF5599 PF18141.1 EXF78159.1 - 1.7e-32 111.5 0.0 3.2e-32 110.6 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF5599) AAA_30 PF13604.6 EXF78159.1 - 5.6e-13 49.0 0.2 8.6e-12 45.2 0.2 2.2 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EXF78159.1 - 1.1e-09 38.8 0.1 3.3e-09 37.2 0.1 1.8 1 1 0 1 1 1 1 AAA domain ResIII PF04851.15 EXF78159.1 - 7.4e-05 22.8 0.0 0.00014 22.0 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_RecD PF05127.14 EXF78159.1 - 0.00011 22.1 0.0 0.00028 20.8 0.0 1.7 1 0 0 1 1 1 1 Helicase Viral_helicase1 PF01443.18 EXF78159.1 - 0.00015 21.6 0.1 0.49 10.1 0.0 2.9 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase DUF2075 PF09848.9 EXF78159.1 - 0.00062 19.1 0.2 0.016 14.5 0.0 2.3 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) PIF1 PF05970.14 EXF78159.1 - 0.001 18.3 0.0 0.31 10.1 0.0 2.2 2 0 0 2 2 2 2 PIF1-like helicase UvrD-helicase PF00580.21 EXF78159.1 - 0.0017 17.9 0.0 0.034 13.7 0.1 2.2 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain DEAD PF00270.29 EXF78159.1 - 0.0068 16.2 0.1 0.012 15.4 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_10 PF12846.7 EXF78159.1 - 0.016 14.2 0.0 0.025 13.5 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain AAA_22 PF13401.6 EXF78159.1 - 0.02 15.2 0.0 0.078 13.3 0.0 2.0 2 0 0 2 2 1 0 AAA domain SRP54 PF00448.22 EXF78159.1 - 0.021 14.5 0.0 0.043 13.4 0.0 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain ATPase PF06745.13 EXF78159.1 - 0.037 13.4 0.0 0.074 12.4 0.0 1.4 1 0 0 1 1 1 0 KaiC AAA_16 PF13191.6 EXF78159.1 - 0.086 13.2 0.0 0.18 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain PhoH PF02562.16 EXF78159.1 - 0.11 11.9 0.0 0.29 10.6 0.0 1.7 2 0 0 2 2 2 0 PhoH-like protein Glyco_hydro_47 PF01532.20 EXF78160.1 - 3.9e-172 573.3 0.0 4.6e-172 573.0 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Glyco_hydro_76 PF03663.14 EXF78160.1 - 0.015 14.8 0.1 0.7 9.4 0.0 2.2 2 0 0 2 2 2 0 Glycosyl hydrolase family 76 RasGAP PF00616.19 EXF78161.1 - 8.5e-29 100.7 0.0 2.3e-20 73.2 0.0 2.6 1 1 1 2 2 2 2 GTPase-activator protein for Ras-like GTPase Pro_isomerase PF00160.21 EXF78162.1 - 1.6e-47 161.7 0.1 2.4e-47 161.2 0.1 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_2 PF07719.17 EXF78162.1 - 1.1e-05 25.2 8.5 0.00014 21.7 0.2 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 EXF78162.1 - 0.0004 20.1 5.4 0.00049 19.8 0.1 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 EXF78162.1 - 0.014 15.6 0.0 0.057 13.6 0.0 2.1 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_16 PF13432.6 EXF78162.1 - 0.029 15.0 1.1 0.029 15.0 1.1 2.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_9 PF13371.6 EXF78162.1 - 0.037 14.2 0.5 0.092 12.9 0.5 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat DUF2341 PF10102.9 EXF78162.1 - 0.11 13.1 0.0 0.35 11.5 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF2341) Tyr_Deacylase PF02580.16 EXF78163.1 - 1.9e-47 161.4 0.0 2.1e-47 161.2 0.0 1.0 1 0 0 1 1 1 1 D-Tyr-tRNA(Tyr) deacylase RhoGAP-FF1 PF16512.5 EXF78163.1 - 0.035 14.8 0.1 0.062 14.0 0.1 1.4 1 0 0 1 1 1 0 p190-A and -B Rho GAPs FF domain Telomere_reg-2 PF10193.9 EXF78163.1 - 0.049 14.1 0.0 0.14 12.6 0.0 1.7 2 0 0 2 2 2 0 Telomere length regulation protein Not3 PF04065.15 EXF78164.1 - 5.9e-90 300.7 25.4 5.9e-90 300.7 25.4 1.9 2 0 0 2 2 2 1 Not1 N-terminal domain, CCR4-Not complex component NOT2_3_5 PF04153.18 EXF78164.1 - 7.2e-42 142.6 5.8 7.2e-42 142.6 5.8 1.9 2 0 0 2 2 2 1 NOT2 / NOT3 / NOT5 family Syntaxin_2 PF14523.6 EXF78164.1 - 0.0054 17.1 3.4 0.0054 17.1 3.4 3.0 3 0 0 3 3 3 1 Syntaxin-like protein DUF1192 PF06698.11 EXF78164.1 - 0.01 15.9 1.9 0.01 15.9 1.9 3.6 4 0 0 4 4 2 1 Protein of unknown function (DUF1192) DUF2373 PF10180.9 EXF78164.1 - 0.027 14.3 3.7 0.059 13.2 3.7 1.6 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2373) HUN PF08729.10 EXF78164.1 - 0.083 12.9 1.5 0.22 11.5 1.5 1.7 1 0 0 1 1 1 0 HPC2 and ubinuclein domain Cep57_MT_bd PF06657.13 EXF78164.1 - 0.19 12.2 10.8 1.1 9.8 2.0 3.0 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 JIP_LZII PF16471.5 EXF78164.1 - 0.85 9.8 7.2 0.2 11.9 1.3 2.7 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II Sec5 PF15469.6 EXF78164.1 - 1.5 8.6 11.0 0.32 10.8 1.6 2.4 2 0 0 2 2 2 0 Exocyst complex component Sec5 DUF2937 PF11157.8 EXF78164.1 - 2.5 7.8 4.4 25 4.5 0.4 3.1 3 1 0 3 3 3 0 Protein of unknown function (DUF2937) CorA PF01544.18 EXF78164.1 - 3.3 6.9 6.7 0.65 9.3 2.0 1.9 1 1 0 2 2 2 0 CorA-like Mg2+ transporter protein SNARE PF05739.19 EXF78164.1 - 3.7 7.6 7.2 0.3 11.1 0.4 2.6 3 0 0 3 3 3 0 SNARE domain 4HB_MCP_1 PF12729.7 EXF78164.1 - 4.2 6.9 15.5 3.1 7.3 8.2 2.5 2 0 0 2 2 2 0 Four helix bundle sensory module for signal transduction zf-C2H2 PF00096.26 EXF78165.1 - 0.082 13.4 0.1 0.082 13.4 0.1 3.9 4 0 0 4 4 4 0 Zinc finger, C2H2 type EMP70 PF02990.16 EXF78166.1 - 2e-206 686.7 0.0 2.5e-206 686.4 0.0 1.1 1 0 0 1 1 1 1 Endomembrane protein 70 ABC_tran PF00005.27 EXF78167.1 - 1.8e-50 171.0 0.0 4.5e-29 101.7 0.0 2.8 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EXF78167.1 - 2.6e-38 132.3 20.2 3.1e-19 69.7 6.3 3.6 3 0 0 3 3 3 2 ABC transporter transmembrane region SMC_N PF02463.19 EXF78167.1 - 6.3e-09 35.6 2.2 0.0085 15.5 0.0 4.2 3 1 1 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EXF78167.1 - 1.7e-07 31.9 3.2 0.00014 22.4 0.2 2.8 3 0 0 3 3 2 2 AAA domain AAA_29 PF13555.6 EXF78167.1 - 8.9e-07 28.6 1.7 0.022 14.5 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_21 PF13304.6 EXF78167.1 - 4.9e-06 26.6 0.2 0.37 10.6 0.0 3.5 4 0 0 4 4 3 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_25 PF13481.6 EXF78167.1 - 6.9e-06 25.8 0.0 0.15 11.6 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EXF78167.1 - 1.7e-05 25.3 0.1 0.14 12.5 0.0 2.9 2 0 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 EXF78167.1 - 2.8e-05 24.1 0.0 0.14 12.1 0.0 2.8 2 0 0 2 2 2 2 RsgA GTPase AAA_22 PF13401.6 EXF78167.1 - 5.3e-05 23.5 0.4 0.55 10.5 0.2 3.3 2 1 0 2 2 2 2 AAA domain T2SSE PF00437.20 EXF78167.1 - 0.00016 20.8 0.4 0.053 12.6 0.1 2.8 2 0 0 2 2 2 1 Type II/IV secretion system protein Viral_helicase1 PF01443.18 EXF78167.1 - 0.0002 21.2 0.1 0.083 12.6 0.0 2.6 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase SbcCD_C PF13558.6 EXF78167.1 - 0.00097 19.3 0.0 1 9.6 0.0 3.0 2 0 0 2 2 2 1 Putative exonuclease SbcCD, C subunit cobW PF02492.19 EXF78167.1 - 0.0016 18.1 2.1 0.49 9.9 1.0 2.3 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.12 EXF78167.1 - 0.0023 17.9 0.2 2.6 7.9 0.0 2.6 2 0 0 2 2 2 2 NACHT domain DUF87 PF01935.17 EXF78167.1 - 0.0023 18.1 5.0 0.0045 17.1 0.1 2.3 2 0 0 2 2 2 1 Helicase HerA, central domain NB-ARC PF00931.22 EXF78167.1 - 0.005 16.0 2.7 2.4 7.3 0.2 3.7 3 1 0 3 3 3 1 NB-ARC domain Pox_A32 PF04665.12 EXF78167.1 - 0.0078 15.7 2.2 0.4 10.1 0.1 2.3 2 0 0 2 2 2 1 Poxvirus A32 protein AAA_30 PF13604.6 EXF78167.1 - 0.0085 15.8 0.6 0.91 9.2 0.0 3.1 3 0 0 3 3 3 1 AAA domain DEAD PF00270.29 EXF78167.1 - 0.014 15.2 0.1 4.4 7.1 0.1 2.9 2 1 0 2 2 2 0 DEAD/DEAH box helicase Dynamin_N PF00350.23 EXF78167.1 - 0.014 15.4 1.0 3.9 7.5 0.1 2.6 2 0 0 2 2 2 0 Dynamin family FtsK_SpoIIIE PF01580.18 EXF78167.1 - 0.014 14.7 0.1 0.32 10.3 0.0 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family MMR_HSR1 PF01926.23 EXF78167.1 - 0.019 15.0 7.2 0.04 14.0 0.1 3.1 3 0 0 3 3 2 0 50S ribosome-binding GTPase AAA_33 PF13671.6 EXF78167.1 - 0.021 15.0 1.5 8.1 6.6 0.1 3.0 3 0 0 3 3 2 0 AAA domain AAA_15 PF13175.6 EXF78167.1 - 0.031 14.0 0.3 0.93 9.1 0.1 2.2 2 0 0 2 2 2 0 AAA ATPase domain DUF2075 PF09848.9 EXF78167.1 - 0.04 13.2 0.1 0.49 9.6 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) MobB PF03205.14 EXF78167.1 - 0.04 13.8 0.8 2.8 7.9 0.1 2.6 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_18 PF13238.6 EXF78167.1 - 0.045 14.3 0.1 13 6.4 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_10 PF12846.7 EXF78167.1 - 0.057 12.3 0.0 0.11 11.4 0.0 1.4 1 0 0 1 1 1 0 AAA-like domain Septin PF00735.18 EXF78167.1 - 0.064 12.5 0.1 11 5.1 0.0 2.3 2 0 0 2 2 2 0 Septin CbiA PF01656.23 EXF78167.1 - 0.093 12.8 0.3 7.2 6.7 0.0 2.9 2 1 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain Roc PF08477.13 EXF78167.1 - 0.1 12.8 0.6 25 5.1 0.1 2.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_14 PF13173.6 EXF78167.1 - 0.12 12.5 0.1 13 5.8 0.0 2.7 3 0 0 3 3 2 0 AAA domain NTPase_1 PF03266.15 EXF78167.1 - 0.12 12.3 2.3 6.3 6.7 0.0 2.4 2 0 0 2 2 2 0 NTPase AAA_7 PF12775.7 EXF78167.1 - 0.12 11.9 0.3 2.7 7.5 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_24 PF13479.6 EXF78167.1 - 0.18 11.5 0.5 9.5 5.9 0.0 2.4 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 EXF78167.1 - 0.24 10.7 3.1 38 3.5 0.0 3.2 3 0 0 3 3 3 0 KaiC ATP_bind_1 PF03029.17 EXF78167.1 - 0.83 9.4 2.2 8.6 6.1 0.1 2.5 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein Aldolase_II PF00596.21 EXF78168.1 - 2.1e-44 151.7 0.0 3.9e-44 150.8 0.0 1.4 2 0 0 2 2 2 1 Class II Aldolase and Adducin N-terminal domain DUF3148 PF11347.8 EXF78168.1 - 0.19 11.5 0.0 0.45 10.3 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3148) Methyltr_RsmB-F PF01189.17 EXF78169.1 - 7.4e-32 110.6 0.0 4.7e-25 88.4 0.0 3.1 2 1 0 2 2 2 2 16S rRNA methyltransferase RsmB/F Hamartin PF04388.12 EXF78169.1 - 4.7 5.7 8.5 7.1 5.2 8.5 1.1 1 0 0 1 1 1 0 Hamartin protein DHQ_synthase PF01761.20 EXF78170.1 - 1e-52 179.0 0.0 1.5e-52 178.4 0.0 1.2 1 0 0 1 1 1 1 3-dehydroquinate synthase Fe-ADH_2 PF13685.6 EXF78170.1 - 1.7e-13 50.8 0.0 2.8e-13 50.2 0.0 1.3 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH PF00465.19 EXF78170.1 - 9.1e-05 21.4 0.0 0.00015 20.8 0.0 1.3 1 1 0 1 1 1 1 Iron-containing alcohol dehydrogenase Methyltransf_3 PF01596.17 EXF78171.1 - 4.6e-11 42.3 0.0 6.4e-11 41.8 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.6 EXF78171.1 - 3.6e-09 37.6 0.0 6.1e-09 36.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Mito_carr PF00153.27 EXF78172.1 - 1.2e-60 201.4 4.4 2.3e-22 78.7 0.1 3.5 3 1 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 EXF78172.1 - 0.12 11.5 0.0 4.2 6.4 0.0 2.5 2 1 0 2 2 2 0 Gammaproteobacterial serine protease MT-A70 PF05063.14 EXF78173.1 - 5.5e-32 111.0 0.0 7.8e-32 110.5 0.0 1.2 1 0 0 1 1 1 1 MT-A70 Ribosomal_L23 PF00276.20 EXF78174.1 - 7.3e-12 45.5 0.2 1.3e-11 44.7 0.2 1.4 1 0 0 1 1 1 1 Ribosomal protein L23 DJ-1_PfpI PF01965.24 EXF78175.1 - 1.1e-11 44.8 0.0 2.3e-11 43.8 0.0 1.5 2 0 0 2 2 2 1 DJ-1/PfpI family ThiJ_like PF17124.5 EXF78175.1 - 0.012 15.3 0.0 0.016 14.9 0.0 1.1 1 0 0 1 1 1 0 ThiJ/PfpI family-like Hamartin PF04388.12 EXF78176.1 - 1.6e-26 93.2 2.0 1.6e-26 93.2 2.0 3.5 2 1 1 3 3 3 2 Hamartin protein Tuberin PF03542.16 EXF78176.1 - 0.062 12.4 0.1 0.062 12.4 0.1 1.9 2 0 0 2 2 2 0 Tuberin Macoilin PF09726.9 EXF78176.1 - 1.8 7.0 45.7 5.4 5.5 45.7 1.7 1 1 0 1 1 1 0 Macoilin family ABC_membrane PF00664.23 EXF78177.1 - 3.9e-82 276.0 31.7 4.7e-46 157.6 7.3 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EXF78177.1 - 1.8e-60 203.4 0.0 6.9e-29 101.1 0.0 3.2 2 1 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EXF78177.1 - 7.8e-15 54.9 0.0 3.7e-07 29.8 0.0 3.8 2 2 1 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 EXF78177.1 - 7.8e-09 35.9 0.0 0.0031 17.8 0.0 3.9 3 1 0 3 3 3 2 AAA domain AAA_16 PF13191.6 EXF78177.1 - 1.4e-08 35.3 1.3 0.0022 18.4 0.3 3.9 2 2 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.6 EXF78177.1 - 1.3e-07 31.3 0.5 0.0018 17.9 0.1 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EXF78177.1 - 1.2e-06 28.5 0.0 0.063 13.2 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase AAA_21 PF13304.6 EXF78177.1 - 1.7e-05 24.8 0.0 0.28 11.0 0.0 3.3 2 1 1 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system ABC_ATPase PF09818.9 EXF78177.1 - 1.7e-05 23.8 0.2 0.022 13.5 0.0 2.4 2 0 0 2 2 2 2 Predicted ATPase of the ABC class AAA PF00004.29 EXF78177.1 - 3.7e-05 24.1 1.5 0.72 10.3 0.2 4.2 3 1 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 EXF78177.1 - 4.1e-05 23.2 0.0 0.12 11.8 0.0 2.3 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_5 PF07728.14 EXF78177.1 - 7.8e-05 22.7 0.1 0.73 9.8 0.0 3.5 4 0 0 4 4 4 2 AAA domain (dynein-related subfamily) AAA_15 PF13175.6 EXF78177.1 - 9.8e-05 22.2 0.0 0.012 15.3 0.0 2.2 2 0 0 2 2 2 1 AAA ATPase domain IstB_IS21 PF01695.17 EXF78177.1 - 0.00017 21.4 0.3 0.057 13.1 0.0 3.3 4 0 0 4 4 3 1 IstB-like ATP binding protein SbcCD_C PF13558.6 EXF78177.1 - 0.00018 21.7 3.6 0.74 10.1 0.2 4.1 2 2 0 2 2 2 2 Putative exonuclease SbcCD, C subunit AAA_18 PF13238.6 EXF78177.1 - 0.00021 21.9 0.0 0.79 10.3 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_30 PF13604.6 EXF78177.1 - 0.00021 21.1 2.9 1.5 8.5 0.0 4.2 5 0 0 5 5 4 2 AAA domain Rad17 PF03215.15 EXF78177.1 - 0.00036 20.5 0.0 0.39 10.6 0.0 2.4 2 0 0 2 2 2 2 Rad17 P-loop domain AAA_23 PF13476.6 EXF78177.1 - 0.00045 20.8 0.2 0.93 10.0 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_28 PF13521.6 EXF78177.1 - 0.00071 19.9 0.0 1.9 8.7 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.6 EXF78177.1 - 0.0011 19.1 0.1 1.6 8.9 0.0 2.8 3 0 0 3 3 2 1 AAA domain AAA_24 PF13479.6 EXF78177.1 - 0.0019 17.9 0.0 1.4 8.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain SRP54 PF00448.22 EXF78177.1 - 0.0044 16.7 0.0 4.2 6.9 0.0 2.6 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain ATP_bind_1 PF03029.17 EXF78177.1 - 0.0053 16.6 0.0 1.2 8.9 0.0 2.4 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein AAA_25 PF13481.6 EXF78177.1 - 0.0057 16.2 2.0 4.5 6.8 0.0 4.2 5 0 0 5 5 5 1 AAA domain ATP-synt_ab PF00006.25 EXF78177.1 - 0.019 14.6 0.0 3.9 7.1 0.0 2.5 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain NB-ARC PF00931.22 EXF78177.1 - 0.02 14.1 0.0 9.2 5.4 0.0 2.8 4 0 0 4 4 3 0 NB-ARC domain RNA_helicase PF00910.22 EXF78177.1 - 0.025 15.0 0.0 6.8 7.1 0.0 2.6 2 0 0 2 2 2 0 RNA helicase TniB PF05621.11 EXF78177.1 - 0.03 13.7 0.1 17 4.8 0.0 3.4 4 0 0 4 4 4 0 Bacterial TniB protein Roc PF08477.13 EXF78177.1 - 0.065 13.5 0.0 18 5.6 0.0 3.1 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase NTPase_1 PF03266.15 EXF78177.1 - 0.082 12.8 0.3 54 3.6 0.0 3.6 4 0 0 4 4 4 0 NTPase DEAD PF00270.29 EXF78177.1 - 0.084 12.6 0.0 88 2.8 0.0 3.7 3 1 0 3 3 3 0 DEAD/DEAH box helicase APS_kinase PF01583.20 EXF78177.1 - 0.095 12.6 0.0 13 5.6 0.0 3.5 4 0 0 4 4 3 0 Adenylylsulphate kinase AAA_17 PF13207.6 EXF78177.1 - 0.095 13.1 0.0 22 5.5 0.0 3.3 3 0 0 3 3 3 0 AAA domain G-alpha PF00503.20 EXF78177.1 - 0.18 11.0 0.0 7.1 5.7 0.0 2.1 2 0 0 2 2 2 0 G-protein alpha subunit DUF2057 PF09829.9 EXF78177.1 - 2.3 8.3 5.4 14 5.7 0.0 2.6 3 0 0 3 3 2 0 Uncharacterized protein conserved in bacteria (DUF2057) Glyco_hydro_17 PF00332.18 EXF78179.1 - 5.4e-07 29.5 0.7 1.3e-06 28.3 0.7 1.6 1 1 0 1 1 1 1 Glycosyl hydrolases family 17 GTP1_OBG PF01018.22 EXF78180.1 - 1.8e-39 134.9 0.2 9.8e-30 103.2 1.6 2.5 2 0 0 2 2 2 2 GTP1/OBG MMR_HSR1 PF01926.23 EXF78180.1 - 1.4e-23 83.1 0.0 3.7e-23 81.8 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EXF78180.1 - 6.3e-08 32.3 0.1 1.9e-07 30.7 0.1 1.8 2 0 0 2 2 2 1 Ferrous iron transport protein B MeaB PF03308.16 EXF78180.1 - 0.02 13.9 4.5 0.86 8.5 0.0 2.8 3 0 0 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB ABC_tran PF00005.27 EXF78180.1 - 0.029 14.9 0.5 0.073 13.6 0.0 1.9 2 0 0 2 2 2 0 ABC transporter GTP_EFTU PF00009.27 EXF78180.1 - 0.065 12.8 0.0 2.5 7.6 0.0 2.4 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain GCV_T PF01571.21 EXF78182.1 - 3.3e-76 256.1 0.0 4.2e-76 255.7 0.0 1.1 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.11 EXF78182.1 - 1.3e-22 79.5 0.4 3e-22 78.3 0.4 1.6 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain Rhomboid PF01694.22 EXF78183.1 - 2.8e-15 56.6 9.1 2.8e-15 56.6 9.1 1.9 2 0 0 2 2 2 1 Rhomboid family DUF2070 PF09843.9 EXF78183.1 - 0.63 8.3 10.8 0.86 7.8 10.8 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Aconitase PF00330.20 EXF78184.1 - 4.1e-150 500.8 0.0 5.2e-150 500.5 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 EXF78184.1 - 1.1e-42 145.5 0.0 1.9e-42 144.7 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain Sdh5 PF03937.16 EXF78184.1 - 0.22 11.5 0.0 0.45 10.5 0.0 1.4 1 0 0 1 1 1 0 Flavinator of succinate dehydrogenase Metallophos PF00149.28 EXF78186.1 - 7.7e-10 39.6 0.9 1.3e-09 38.8 0.9 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase CDC45 PF02724.14 EXF78186.1 - 8.1 4.6 24.3 0.53 8.5 18.0 2.0 3 0 0 3 3 3 0 CDC45-like protein Ofd1_CTDD PF10637.9 EXF78187.1 - 1e-96 323.2 0.0 2.9e-91 305.4 0.0 2.2 2 0 0 2 2 2 2 Oxoglutarate and iron-dependent oxygenase degradation C-term 2OG-FeII_Oxy_4 PF13661.6 EXF78187.1 - 5.3e-25 87.9 0.0 2.2e-24 85.9 0.0 2.1 2 1 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.6 EXF78187.1 - 8.5e-12 45.8 0.0 1.9e-11 44.7 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Aminotran_5 PF00266.19 EXF78188.1 - 3.1e-55 187.7 0.0 4.7e-55 187.0 0.0 1.3 1 1 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 EXF78188.1 - 0.00021 20.0 0.0 0.00031 19.4 0.0 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 EXF78188.1 - 0.019 14.1 0.0 0.029 13.5 0.0 1.3 1 0 0 1 1 1 0 Aminotransferase class I and II Ribul_P_3_epim PF00834.19 EXF78189.1 - 5.9e-57 192.3 0.0 2e-55 187.3 0.0 2.7 1 1 0 1 1 1 1 Ribulose-phosphate 3 epimerase family ThiG PF05690.14 EXF78189.1 - 0.012 15.0 0.1 0.016 14.5 0.1 1.2 1 0 0 1 1 1 0 Thiazole biosynthesis protein ThiG OMPdecase PF00215.24 EXF78189.1 - 0.044 13.4 0.1 0.076 12.6 0.0 1.5 2 0 0 2 2 2 0 Orotidine 5'-phosphate decarboxylase / HUMPS family QRPTase_C PF01729.19 EXF78189.1 - 0.14 11.9 0.0 0.24 11.2 0.0 1.3 1 0 0 1 1 1 0 Quinolinate phosphoribosyl transferase, C-terminal domain V-ATPase_H_N PF03224.14 EXF78190.1 - 1.1e-76 258.2 0.0 1.5e-76 257.7 0.0 1.2 1 0 0 1 1 1 1 V-ATPase subunit H V-ATPase_H_C PF11698.8 EXF78190.1 - 8.3e-36 122.6 0.0 3.4e-35 120.7 0.0 2.1 2 0 0 2 2 2 1 V-ATPase subunit H DUF4690 PF15756.5 EXF78191.1 - 3.9 8.1 7.6 0.7 10.5 1.7 2.6 3 0 0 3 3 3 0 Small Novel Rich in Cartilage Ribosomal_L6 PF00347.23 EXF78192.1 - 1.1e-26 93.3 7.5 9.4e-14 51.9 3.3 2.1 2 0 0 2 2 2 2 Ribosomal protein L6 Vps26 PF03643.15 EXF78193.1 - 7.7e-126 418.7 1.6 4.5e-125 416.2 1.6 1.8 1 1 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_N PF00339.29 EXF78193.1 - 6.5e-05 23.0 0.5 0.0047 17.0 0.1 2.8 1 1 2 3 3 3 1 Arrestin (or S-antigen), N-terminal domain IL17R_D_N PF16742.5 EXF78193.1 - 0.065 13.3 0.1 0.14 12.2 0.1 1.5 1 0 0 1 1 1 0 N-terminus of interleukin 17 receptor D Tim54 PF11711.8 EXF78194.1 - 4.7e-141 469.9 0.5 6e-141 469.6 0.5 1.1 1 0 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 NAM-associated PF14303.6 EXF78194.1 - 0.0048 17.6 0.0 0.2 12.4 0.0 2.8 2 1 0 2 2 2 1 No apical meristem-associated C-terminal domain Nefa_Nip30_N PF10187.9 EXF78195.1 - 1.9e-30 105.3 13.5 1.9e-30 105.3 13.5 2.5 3 0 0 3 3 3 1 N-terminal domain of NEFA-interacting nuclear protein NIP30 NICE-1 PF15845.5 EXF78195.1 - 3.2 8.6 8.3 1.5 9.6 1.2 3.1 3 0 0 3 3 3 0 Cysteine-rich C-terminal 1 family Cyclin PF08613.11 EXF78196.1 - 1.3e-09 38.6 0.0 2.2e-09 37.9 0.0 1.3 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 EXF78196.1 - 0.034 13.9 0.0 0.063 13.0 0.0 1.4 1 0 0 1 1 1 0 Cyclin, N-terminal domain Methyltransf_2 PF00891.18 EXF78198.1 - 3.7e-24 85.2 0.0 5.5e-24 84.6 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain MarR_2 PF12802.7 EXF78198.1 - 0.00015 21.6 0.0 0.00035 20.4 0.0 1.5 1 0 0 1 1 1 1 MarR family mTERF PF02536.14 EXF78198.1 - 0.082 11.8 0.0 0.4 9.6 0.0 1.9 2 0 0 2 2 2 0 mTERF MTS PF05175.14 EXF78198.1 - 0.2 11.2 0.1 0.49 9.9 0.0 1.6 2 0 0 2 2 2 0 Methyltransferase small domain CRC_subunit PF08624.10 EXF78200.1 - 3.3e-53 179.7 0.0 5.2e-53 179.1 0.0 1.3 1 0 0 1 1 1 1 Chromatin remodelling complex Rsc7/Swp82 subunit Nop14 PF04147.12 EXF78200.1 - 0.3 9.3 17.5 0.41 8.8 17.5 1.1 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 EXF78200.1 - 0.32 9.3 11.5 0.46 8.7 11.5 1.2 1 0 0 1 1 1 0 CDC45-like protein SDA1 PF05285.12 EXF78200.1 - 0.57 9.5 17.6 1 8.7 17.6 1.3 1 0 0 1 1 1 0 SDA1 Paf1 PF03985.13 EXF78200.1 - 8.6 5.2 20.0 14 4.6 20.0 1.2 1 0 0 1 1 1 0 Paf1 CPSF100_C PF13299.6 EXF78200.1 - 9.7 6.3 6.5 27 4.9 6.5 1.7 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal TFIIB PF00382.19 EXF78201.1 - 1.1e-41 140.7 1.4 7.1e-23 80.5 0.0 2.5 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 EXF78201.1 - 6.2e-14 51.2 1.8 1.1e-13 50.4 1.8 1.5 1 0 0 1 1 1 1 TFIIB zinc-binding Cyclin_C PF02984.19 EXF78201.1 - 0.0002 21.4 0.0 0.32 11.1 0.1 2.5 2 0 0 2 2 2 2 Cyclin, C-terminal domain RB_B PF01857.20 EXF78201.1 - 0.023 14.7 0.0 0.11 12.5 0.0 2.1 1 1 1 2 2 2 0 Retinoblastoma-associated protein B domain VIR_N PF15912.5 EXF78201.1 - 0.039 13.5 0.1 0.039 13.5 0.1 1.8 2 0 0 2 2 2 0 Virilizer, N-terminal Sigma70_r4_2 PF08281.12 EXF78201.1 - 0.063 13.0 0.1 0.2 11.4 0.1 1.8 1 0 0 1 1 1 0 Sigma-70, region 4 HTH_Tnp_ISL3 PF13542.6 EXF78201.1 - 0.072 12.5 0.1 0.64 9.5 0.0 2.4 2 0 0 2 2 2 0 Helix-turn-helix domain of transposase family ISL3 PRIMA1 PF16101.5 EXF78201.1 - 0.15 12.1 9.1 3.1 7.8 3.6 2.6 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 Trp_repressor PF01371.19 EXF78201.1 - 0.16 12.1 2.0 18 5.5 0.0 2.9 3 0 0 3 3 3 0 Trp repressor protein Mito_fiss_reg PF05308.11 EXF78201.1 - 0.82 9.7 3.8 1.3 9.1 0.1 2.4 2 0 0 2 2 2 0 Mitochondrial fission regulator CitMHS PF03600.16 EXF78202.1 - 1.5e-13 50.6 1.3 3.2e-13 49.5 1.3 1.5 1 0 0 1 1 1 1 Citrate transporter ArsB PF02040.15 EXF78202.1 - 2.3e-12 47.0 16.8 2.1e-08 33.9 6.6 2.2 2 0 0 2 2 2 2 Arsenical pump membrane protein CEND1 PF15677.5 EXF78202.1 - 9.1 6.8 9.4 0.58 10.7 0.3 2.3 2 0 0 2 2 2 0 Cell cycle exit and neuronal differentiation protein 1 CoA_transf_3 PF02515.17 EXF78203.1 - 5.4e-127 423.9 0.0 7.3e-127 423.5 0.0 1.2 1 0 0 1 1 1 1 CoA-transferase family III PHD PF00628.29 EXF78204.1 - 0.00012 21.9 5.1 0.00027 20.7 5.1 1.6 1 0 0 1 1 1 1 PHD-finger DUF2397 PF09660.10 EXF78205.1 - 0.4 9.5 1.0 0.56 9.1 1.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2397) Glyco_transf_4 PF13439.6 EXF78205.1 - 7.4 6.5 6.5 5.9 6.9 0.5 2.3 1 1 1 2 2 2 0 Glycosyltransferase Family 4 MFS_1 PF07690.16 EXF78208.1 - 3.3e-26 92.1 30.7 1.2e-17 63.9 17.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 EXF78208.1 - 1e-07 31.2 15.1 0.00048 19.1 3.6 2.1 2 0 0 2 2 2 2 MFS_1 like family Sugar_tr PF00083.24 EXF78208.1 - 0.0017 17.3 22.1 0.0018 17.2 13.6 2.2 2 0 0 2 2 2 2 Sugar (and other) transporter OATP PF03137.20 EXF78208.1 - 0.21 9.8 8.1 0.082 11.2 2.1 2.2 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family DUF3176 PF11374.8 EXF78209.1 - 3.7e-34 117.1 0.8 3.7e-34 117.1 0.8 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF3176) Corona_S2 PF01601.16 EXF78209.1 - 0.1 11.0 0.1 0.16 10.4 0.1 1.1 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein Asn_synthase PF00733.21 EXF78210.1 - 2.5e-19 70.1 1.2 3e-09 37.0 0.1 3.2 2 1 1 3 3 3 3 Asparagine synthase GATase_7 PF13537.6 EXF78210.1 - 1.2e-07 31.7 0.0 6.5e-07 29.3 0.0 2.2 1 1 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 EXF78210.1 - 0.00052 20.2 0.0 0.0014 18.8 0.0 1.7 1 0 0 1 1 1 1 Glutamine amidotransferase domain DUF3700 PF12481.8 EXF78210.1 - 0.0016 17.9 0.0 0.0026 17.3 0.0 1.2 1 0 0 1 1 1 1 Aluminium induced protein 3HCDH_N PF02737.18 EXF78211.1 - 2.2e-20 73.3 0.0 3.3e-20 72.7 0.0 1.2 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 EXF78211.1 - 3.5e-14 53.2 0.0 5.4e-14 52.6 0.0 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain TarS_C1 PF18674.1 EXF78212.1 - 0.1 12.5 0.0 0.18 11.7 0.0 1.3 1 0 0 1 1 1 0 TarS beta-glycosyltransferase C-terminal domain 1 DUF3425 PF11905.8 EXF78212.1 - 0.28 11.1 2.3 20 5.2 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3425) DUF2430 PF10353.9 EXF78214.1 - 0.17 12.3 0.0 0.34 11.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2430) Peptidase_M28 PF04389.17 EXF78215.1 - 6.9e-35 120.5 0.0 9.2e-35 120.1 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M28 MFS_1 PF07690.16 EXF78216.1 - 4.1e-31 108.2 48.5 8.4e-30 103.9 48.5 2.3 1 1 0 1 1 1 1 Major Facilitator Superfamily HSP70 PF00012.20 EXF78216.1 - 2.5e-14 52.4 0.0 4.4e-13 48.3 0.0 2.0 2 0 0 2 2 2 2 Hsp70 protein ATG19_autophagy PF12744.7 EXF78216.1 - 0.13 11.4 0.0 0.27 10.4 0.0 1.4 1 0 0 1 1 1 0 Autophagy protein Atg19, Atg8-binding Not3 PF04065.15 EXF78217.1 - 0.0016 17.9 7.9 0.0026 17.2 0.7 2.2 1 1 1 2 2 2 1 Not1 N-terminal domain, CCR4-Not complex component V_ATPase_I PF01496.19 EXF78217.1 - 0.0084 14.1 0.3 0.01 13.8 0.3 1.1 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family APG6_N PF17675.1 EXF78217.1 - 0.016 15.7 14.1 0.032 14.8 14.1 1.5 1 0 0 1 1 1 0 Apg6 coiled-coil region Med30 PF11315.8 EXF78217.1 - 0.05 13.8 5.6 0.1 12.8 5.6 1.4 1 0 0 1 1 1 0 Mediator complex subunit 30 UPF0242 PF06785.11 EXF78217.1 - 0.13 12.4 8.6 0.21 11.7 8.6 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Fez1 PF06818.15 EXF78217.1 - 0.13 12.7 8.3 0.21 12.0 8.3 1.3 1 0 0 1 1 1 0 Fez1 Atg14 PF10186.9 EXF78217.1 - 0.15 11.1 6.7 0.21 10.6 6.7 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Tudor_3 PF18115.1 EXF78217.1 - 0.18 11.7 0.0 0.36 10.7 0.0 1.5 1 0 0 1 1 1 0 DNA repair protein Crb2 Tudor domain Sec34 PF04136.15 EXF78217.1 - 0.23 11.4 4.8 0.48 10.3 4.2 1.8 1 1 0 1 1 1 0 Sec34-like family FapA PF03961.13 EXF78217.1 - 0.3 9.6 3.7 0.49 9.0 3.7 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A FliD_N PF02465.18 EXF78217.1 - 0.51 11.1 7.6 0.24 12.1 1.0 2.3 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 N-terminus Fungal_TACC PF12709.7 EXF78217.1 - 0.66 10.5 8.6 0.85 10.1 0.4 2.9 3 0 0 3 3 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins DUF2937 PF11157.8 EXF78217.1 - 0.88 9.3 5.8 3 7.5 0.5 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2937) DUF4200 PF13863.6 EXF78217.1 - 1.2 9.6 20.0 0.98 9.8 17.4 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4200) DMSP_lyase PF16867.5 EXF78217.1 - 2.1 8.0 3.6 5.1 6.7 0.0 2.4 1 1 1 2 2 2 0 Dimethlysulfonioproprionate lyase Golgin_A5 PF09787.9 EXF78217.1 - 2.1 7.7 11.9 3.7 6.9 11.9 1.3 1 0 0 1 1 1 0 Golgin subfamily A member 5 XhlA PF10779.9 EXF78217.1 - 2.2 8.5 12.0 2.5 8.4 1.6 2.6 2 0 0 2 2 2 0 Haemolysin XhlA DUF1664 PF07889.12 EXF78217.1 - 2.3 8.3 5.8 10 6.2 0.4 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) FUSC PF04632.12 EXF78217.1 - 2.8 6.4 5.4 3.6 6.0 5.4 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family TMF_TATA_bd PF12325.8 EXF78217.1 - 2.9 8.2 13.3 6.3 7.0 12.4 2.0 2 1 0 2 2 1 0 TATA element modulatory factor 1 TATA binding TMF_DNA_bd PF12329.8 EXF78217.1 - 2.9 7.9 14.0 2.1 8.4 3.2 2.5 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Phage_GPO PF05929.11 EXF78217.1 - 3.3 7.3 8.4 5.5 6.5 8.4 1.3 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase DUF4407 PF14362.6 EXF78217.1 - 4.5 6.5 9.3 7 5.9 9.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Prefoldin_2 PF01920.20 EXF78217.1 - 4.6 7.2 14.6 2.1 8.3 0.7 2.9 4 0 0 4 4 2 0 Prefoldin subunit ANAPC15 PF15243.6 EXF78217.1 - 7.2 7.1 9.2 1.1 9.6 3.5 2.3 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 15 MFS_1 PF07690.16 EXF78218.1 - 1.1e-34 119.9 45.3 3.1e-30 105.3 40.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 EXF78218.1 - 0.0025 17.2 21.8 0.0058 16.0 21.8 1.5 1 1 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB CorA PF01544.18 EXF78219.1 - 0.004 16.5 0.0 0.004 16.5 0.0 1.7 2 0 0 2 2 2 1 CorA-like Mg2+ transporter protein CAP PF00188.26 EXF78220.1 - 2e-11 44.8 0.0 3e-11 44.3 0.0 1.3 1 0 0 1 1 1 1 Cysteine-rich secretory protein family DPBB_1 PF03330.18 EXF78220.1 - 2e-05 24.8 0.0 4.2e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 Lytic transglycolase Amidoligase_2 PF12224.8 EXF78221.1 - 4.9e-15 55.9 0.0 2.2e-07 30.8 0.0 4.8 4 1 0 4 4 4 3 Putative amidoligase enzyme SNF5 PF04855.12 EXF78222.1 - 4.1e-91 305.0 0.0 5.1e-91 304.7 0.0 1.1 1 0 0 1 1 1 1 SNF5 / SMARCB1 / INI1 GATA PF00320.27 EXF78222.1 - 0.012 15.2 4.5 0.03 13.9 4.5 1.8 1 0 0 1 1 1 0 GATA zinc finger Glyco_hydro_7 PF00840.20 EXF78223.1 - 8.2e-180 598.2 14.0 8.2e-180 598.2 14.0 2.1 2 1 0 2 2 2 1 Glycosyl hydrolase family 7 CBM_1 PF00734.18 EXF78223.1 - 1.4e-12 47.3 14.3 1.4e-12 47.3 14.3 4.8 4 1 0 4 4 4 1 Fungal cellulose binding domain Toxin_7 PF05980.12 EXF78223.1 - 0.16 12.2 0.3 0.16 12.2 0.3 2.9 4 0 0 4 4 4 0 Toxin 7 Fungal_trans PF04082.18 EXF78224.1 - 3.4e-10 39.4 0.0 6.2e-10 38.6 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain CCD48 PF15799.5 EXF78225.1 - 0.053 11.8 0.0 0.065 11.5 0.0 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 48 Fungal_trans PF04082.18 EXF78226.1 - 4.4e-15 55.4 0.2 1.4e-14 53.8 0.2 1.9 2 0 0 2 2 2 1 Fungal specific transcription factor domain EMC3_TMCO1 PF01956.16 EXF78226.1 - 0.088 12.5 0.9 0.24 11.1 0.9 1.7 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like PAT1 PF09770.9 EXF78226.1 - 5.3 5.2 22.5 8.1 4.6 22.5 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Sugar_tr PF00083.24 EXF78227.1 - 1.1e-99 334.3 23.4 1.3e-99 334.2 23.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF78227.1 - 6.3e-32 110.9 26.3 8.1e-26 90.8 2.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily LRR19-TM PF15176.6 EXF78227.1 - 0.16 12.0 0.8 1.5 8.8 0.0 2.8 3 0 0 3 3 3 0 Leucine-rich repeat family 19 TM domain OATP PF03137.20 EXF78227.1 - 0.49 8.6 13.0 0.01 14.1 2.3 2.9 1 1 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family TPR_9 PF13371.6 EXF78228.1 - 0.014 15.5 0.1 0.046 13.9 0.1 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat PD40 PF07676.12 EXF78229.1 - 0.084 12.8 0.1 0.86 9.6 0.0 2.8 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat DPPIV_N PF00930.21 EXF78229.1 - 0.18 10.5 0.0 1.7 7.3 0.0 2.0 2 0 0 2 2 2 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region Glyco_hydro_2_C PF02836.17 EXF78230.1 - 0.02 14.0 0.0 0.03 13.4 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolases family 2, TIM barrel domain Fungal_trans_2 PF11951.8 EXF78231.1 - 2.8e-05 23.1 0.0 5.7e-05 22.1 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Alpha_L_fucos PF01120.17 EXF78234.1 - 1.7e-88 297.4 6.5 2.3e-88 297.0 6.5 1.1 1 0 0 1 1 1 1 Alpha-L-fucosidase GHL6 PF14871.6 EXF78234.1 - 0.16 12.1 0.0 0.39 10.9 0.0 1.6 1 0 0 1 1 1 0 Hypothetical glycosyl hydrolase 6 Lipase_3 PF01764.25 EXF78235.1 - 3.7e-06 26.9 0.0 8.5e-06 25.7 0.0 1.8 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_6 PF12697.7 EXF78235.1 - 0.03 14.9 0.1 0.04 14.5 0.1 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family Cutinase PF01083.22 EXF78236.1 - 1.8e-46 158.3 2.4 2.4e-46 157.9 2.4 1.1 1 0 0 1 1 1 1 Cutinase PE-PPE PF08237.11 EXF78236.1 - 8.9e-05 22.1 0.2 0.00018 21.1 0.2 1.5 1 1 0 1 1 1 1 PE-PPE domain VirJ PF06057.11 EXF78236.1 - 0.13 12.1 0.0 0.19 11.6 0.0 1.2 1 0 0 1 1 1 0 Bacterial virulence protein (VirJ) Glyco_hydro_43 PF04616.14 EXF78237.1 - 4.1e-43 147.7 3.5 5.5e-43 147.3 3.5 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 GH43_C2 PF17851.1 EXF78237.1 - 1.5e-21 77.1 0.0 2.1e-21 76.6 0.0 1.2 1 0 0 1 1 1 1 Beta xylosidase C-terminal Concanavalin A-like domain GST_N PF02798.20 EXF78238.1 - 9.1e-09 35.6 0.1 1.6e-08 34.8 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EXF78238.1 - 1.5e-07 31.6 0.0 2.8e-07 30.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EXF78238.1 - 2.4e-06 27.5 0.0 7.8e-06 25.8 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EXF78238.1 - 4.2e-06 27.1 0.0 7.5e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EXF78238.1 - 1.8e-05 24.8 0.0 3.5e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 EXF78238.1 - 0.00014 22.1 0.0 0.00024 21.4 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Fungal_trans PF04082.18 EXF78239.1 - 3.3e-09 36.2 0.3 1.1e-08 34.4 0.3 2.0 1 1 0 1 1 1 1 Fungal specific transcription factor domain DIOX_N PF14226.6 EXF78240.1 - 5.1e-14 53.0 0.0 7.4e-13 49.3 0.0 2.2 2 0 0 2 2 2 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EXF78240.1 - 2.3e-11 44.1 0.0 4.1e-11 43.3 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily MFS_1 PF07690.16 EXF78241.1 - 1.2e-31 110.0 22.5 3.4e-31 108.4 22.7 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily Baculo_11_kDa PF06143.11 EXF78241.1 - 0.37 10.4 1.9 0.85 9.2 1.9 1.5 1 0 0 1 1 1 0 Baculovirus 11 kDa family Zn_clus PF00172.18 EXF78242.1 - 3.3e-09 36.7 8.1 6.9e-09 35.7 8.1 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EXF78242.1 - 6.1e-08 31.9 0.3 9.2e-08 31.3 0.3 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain 2OG-FeII_Oxy PF03171.20 EXF78242.1 - 0.00088 19.7 0.2 0.032 14.7 0.2 2.5 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Fungal_trans PF04082.18 EXF78242.1 - 0.0031 16.6 0.1 0.0082 15.2 0.0 1.7 1 1 0 1 1 1 1 Fungal specific transcription factor domain ADH_zinc_N PF00107.26 EXF78243.1 - 1.4e-21 76.8 0.3 3e-21 75.8 0.3 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EXF78243.1 - 1.6e-21 76.3 2.4 4.2e-21 74.9 1.7 2.0 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain TrkA_N PF02254.18 EXF78243.1 - 0.069 13.4 0.5 0.12 12.7 0.5 1.4 1 0 0 1 1 1 0 TrkA-N domain ADH_zinc_N_2 PF13602.6 EXF78243.1 - 0.09 13.8 0.0 0.17 13.0 0.0 1.4 1 0 0 1 1 1 0 Zinc-binding dehydrogenase p450 PF00067.22 EXF78245.1 - 6e-51 173.6 0.1 7.7e-51 173.3 0.1 1.1 1 0 0 1 1 1 1 Cytochrome P450 RTA1 PF04479.13 EXF78246.1 - 8.2e-74 247.7 3.4 8.2e-74 247.7 3.4 1.6 2 0 0 2 2 2 1 RTA1 like protein DUF4173 PF13777.6 EXF78246.1 - 0.16 11.4 4.4 0.92 8.9 0.2 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4173) Stevor PF17410.2 EXF78246.1 - 0.18 11.3 0.0 0.28 10.7 0.0 1.2 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame 7TMR-DISM_7TM PF07695.11 EXF78246.1 - 0.68 9.8 14.6 0.049 13.5 3.5 2.4 2 1 0 2 2 2 0 7TM diverse intracellular signalling Cation_ATPase_C PF00689.21 EXF78246.1 - 1.2 8.8 7.6 1.9 8.1 0.9 2.8 2 2 0 2 2 2 0 Cation transporting ATPase, C-terminus Glyco_transf_28 PF03033.20 EXF78247.1 - 4.1e-26 91.7 0.0 1.1e-25 90.2 0.0 1.8 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain VPS13_C PF16909.5 EXF78247.1 - 3.3e-05 23.7 1.2 0.00014 21.7 0.4 2.1 2 0 0 2 2 2 1 Vacuolar-sorting-associated 13 protein C-terminal UDPGT PF00201.18 EXF78247.1 - 0.0034 16.2 0.0 0.0064 15.3 0.0 1.4 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase DUF4140 PF13600.6 EXF78248.1 - 4.8 7.7 24.3 9.3 6.8 1.1 6.7 1 1 5 6 6 6 0 N-terminal domain of unknown function (DUF4140) DUF3172 PF11371.8 EXF78248.1 - 9.4 5.9 6.0 29 4.3 0.2 3.7 2 2 2 4 4 4 0 Protein of unknown function (DUF3172) Lactamase_B PF00753.27 EXF78249.1 - 1.4e-15 57.8 0.0 2.6e-15 57.0 0.0 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EXF78249.1 - 3.9e-05 23.3 0.0 5.6e-05 22.8 0.0 1.4 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 EXF78249.1 - 0.055 13.4 0.0 0.2 11.5 0.0 1.9 2 0 0 2 2 2 0 Beta-lactamase superfamily domain Tautomerase_3 PF14832.6 EXF78250.1 - 2.5e-42 144.4 0.0 2.8e-42 144.2 0.0 1.0 1 0 0 1 1 1 1 Putative oxalocrotonate tautomerase enzyme Tautomerase PF01361.21 EXF78250.1 - 0.018 14.9 0.0 0.037 14.0 0.0 1.5 1 1 0 1 1 1 0 Tautomerase enzyme WSC PF01822.19 EXF78252.1 - 5.8e-07 29.6 9.5 9.5e-07 28.9 9.5 1.3 1 0 0 1 1 1 1 WSC domain DUF2927 PF11150.8 EXF78252.1 - 0.3 11.1 0.8 0.47 10.5 0.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2927) VPS9 PF02204.18 EXF78253.1 - 5.6e-30 103.6 0.1 1.1e-29 102.7 0.1 1.5 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain DUF5601 PF18151.1 EXF78253.1 - 9.1e-17 61.1 0.1 1.9e-16 60.1 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF5601) CUE PF02845.16 EXF78253.1 - 1.7e-10 40.4 0.5 6.8e-10 38.5 0.0 2.1 2 0 0 2 2 2 1 CUE domain Cutinase PF01083.22 EXF78254.1 - 5e-47 160.1 2.4 6e-47 159.9 2.4 1.1 1 0 0 1 1 1 1 Cutinase VirJ PF06057.11 EXF78254.1 - 4e-05 23.6 0.0 5.4e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 Bacterial virulence protein (VirJ) PE-PPE PF08237.11 EXF78254.1 - 0.0014 18.2 0.0 0.002 17.7 0.0 1.2 1 0 0 1 1 1 1 PE-PPE domain Abhydrolase_2 PF02230.16 EXF78254.1 - 0.023 14.5 0.0 0.065 13.0 0.0 1.7 1 1 1 2 2 2 0 Phospholipase/Carboxylesterase DUF2974 PF11187.8 EXF78254.1 - 0.063 12.8 0.0 0.092 12.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Hydrolase_4 PF12146.8 EXF78254.1 - 0.14 11.4 0.0 0.19 10.9 0.0 1.2 1 0 0 1 1 1 0 Serine aminopeptidase, S33 PhoLip_ATPase_C PF16212.5 EXF78255.1 - 2.1e-66 224.2 20.2 4.9e-66 223.0 20.2 1.6 1 0 0 1 1 1 1 Phospholipid-translocating P-type ATPase C-terminal p450 PF00067.22 EXF78255.1 - 2.8e-25 89.0 0.0 2e-22 79.6 0.0 2.3 2 0 0 2 2 2 2 Cytochrome P450 PhoLip_ATPase_N PF16209.5 EXF78255.1 - 3.8e-22 77.8 1.2 4.2e-21 74.4 0.1 2.4 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 EXF78255.1 - 2.3e-11 43.6 0.0 2.2e-10 40.5 0.0 2.4 3 0 0 3 3 3 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 EXF78255.1 - 1e-09 38.2 0.0 3.3e-09 36.5 0.0 1.8 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 EXF78255.1 - 1e-09 39.0 0.2 2.7e-05 24.5 0.0 3.4 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EXF78255.1 - 0.02 14.7 0.0 0.1 12.4 0.0 1.9 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase HSBP1 PF06825.12 EXF78256.1 - 0.0013 18.5 1.1 1.1 9.1 0.0 3.5 4 0 0 4 4 4 2 Heat shock factor binding protein 1 DUF2095 PF09868.9 EXF78256.1 - 0.0099 15.9 0.1 0.04 13.9 0.0 1.9 2 0 0 2 2 2 1 Uncharacterized protein conserved in archaea (DUF2095) HalX PF08663.10 EXF78256.1 - 0.02 15.2 3.0 33 4.9 0.0 3.6 2 1 0 3 3 3 0 HalX domain Bacillus_HBL PF05791.11 EXF78256.1 - 0.03 14.1 9.9 0.056 13.3 0.2 3.1 2 1 0 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) RRM_3 PF08777.11 EXF78256.1 - 0.11 12.5 2.4 0.12 12.5 0.5 2.1 2 0 0 2 2 2 0 RNA binding motif PKcGMP_CC PF16808.5 EXF78256.1 - 1.1 9.1 6.7 0.71 9.8 0.4 3.0 3 0 0 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase MFS_1 PF07690.16 EXF78257.1 - 2.9e-40 138.3 58.5 2e-39 135.5 56.7 2.5 2 1 0 2 2 2 1 Major Facilitator Superfamily Saf_2TM PF18303.1 EXF78257.1 - 4.6 6.8 13.5 0.057 13.0 0.8 3.4 3 0 0 3 3 3 0 SAVED-fused 2TM effector domain F-box PF00646.33 EXF78259.1 - 5.6e-06 26.1 0.1 1.4e-05 24.8 0.1 1.7 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EXF78259.1 - 6.3e-05 22.8 0.0 0.00013 21.8 0.0 1.5 1 0 0 1 1 1 1 F-box-like p450 PF00067.22 EXF78260.1 - 1.2e-50 172.6 0.0 1.8e-48 165.5 0.0 2.0 2 0 0 2 2 2 2 Cytochrome P450 2OG-FeII_Oxy_3 PF13640.6 EXF78264.1 - 0.0079 17.1 0.0 0.045 14.7 0.0 2.0 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily Aldedh PF00171.22 EXF78265.1 - 9e-155 515.7 0.0 1e-154 515.5 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 EXF78265.1 - 0.057 12.9 0.2 0.23 10.9 0.2 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1487) CVNH PF08881.10 EXF78266.1 - 6e-36 123.2 0.2 9.8e-36 122.5 0.2 1.4 1 0 0 1 1 1 1 CVNH domain LysM PF01476.20 EXF78266.1 - 4.8e-15 55.3 0.0 8.1e-15 54.6 0.0 1.4 1 0 0 1 1 1 1 LysM domain Rick_17kDa_Anti PF05433.15 EXF78266.1 - 1.3e-08 34.5 11.5 1.3e-08 34.5 11.5 2.2 2 0 0 2 2 2 1 Glycine zipper 2TM domain Gly-zipper_YMGG PF13441.6 EXF78266.1 - 0.00056 19.6 14.0 0.0021 17.8 14.0 2.0 1 0 0 1 1 1 1 YMGG-like Gly-zipper Gly-zipper_Omp PF13488.6 EXF78266.1 - 0.017 15.1 16.1 0.086 12.9 15.9 2.4 1 1 0 1 1 1 0 Glycine zipper DUF533 PF04391.12 EXF78266.1 - 0.052 13.1 0.0 0.095 12.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF533) Zip PF02535.22 EXF78266.1 - 0.25 10.5 1.9 0.32 10.2 1.9 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter AA_permease PF00324.21 EXF78267.1 - 1.6e-102 343.6 34.1 1.9e-102 343.3 34.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EXF78267.1 - 1.5e-19 70.1 38.2 1.9e-19 69.8 38.2 1.1 1 0 0 1 1 1 1 Amino acid permease FAA_hydrolase PF01557.18 EXF78268.1 - 3.4e-05 23.6 0.0 4.2e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family DUF4141 PF13605.6 EXF78269.1 - 0.22 10.8 0.6 0.37 10.1 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4141) zf-MYND PF01753.18 EXF78273.1 - 1.4e-05 25.1 14.5 4.5e-05 23.4 14.5 2.0 1 0 0 1 1 1 1 MYND finger Ribosomal_L10 PF00466.20 EXF78274.1 - 0.0001 22.4 0.0 0.00039 20.5 0.0 2.0 1 1 0 1 1 1 1 Ribosomal protein L10 DUF5401 PF17380.2 EXF78274.1 - 0.071 11.2 2.7 0.098 10.7 2.7 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5401) AAA PF00004.29 EXF78276.1 - 8.8e-40 136.2 0.0 1.9e-39 135.1 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 EXF78276.1 - 1.2e-18 66.8 0.1 2.4e-18 65.8 0.1 1.6 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 EXF78276.1 - 5.4e-07 29.3 0.0 1.2e-06 28.2 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 EXF78276.1 - 0.00012 22.5 1.7 0.02 15.3 0.0 2.9 2 1 1 3 3 3 1 AAA ATPase domain AAA_5 PF07728.14 EXF78276.1 - 0.0002 21.4 1.5 0.00071 19.6 0.1 2.6 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 EXF78276.1 - 0.00035 20.4 0.0 0.00091 19.0 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 EXF78276.1 - 0.0018 18.4 0.4 0.011 15.9 0.0 2.4 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 EXF78276.1 - 0.0055 17.0 4.0 0.082 13.2 0.0 3.1 3 1 1 4 4 4 1 AAA domain Mg_chelatase PF01078.21 EXF78276.1 - 0.0084 15.5 0.0 0.02 14.3 0.0 1.6 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI DUF815 PF05673.13 EXF78276.1 - 0.011 14.9 0.0 0.027 13.7 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_33 PF13671.6 EXF78276.1 - 0.014 15.6 0.0 0.034 14.3 0.0 1.8 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 EXF78276.1 - 0.015 14.8 2.0 0.08 12.4 0.1 2.5 3 0 0 3 3 3 0 PhoH-like protein IstB_IS21 PF01695.17 EXF78276.1 - 0.072 12.8 0.1 0.18 11.5 0.1 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_7 PF12775.7 EXF78276.1 - 0.11 12.0 0.0 0.31 10.5 0.0 1.8 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_11 PF13086.6 EXF78276.1 - 0.6 9.9 0.0 0.6 9.9 0.0 2.6 3 0 0 3 3 3 0 AAA domain RPN2_C PF18004.1 EXF78276.1 - 1.3 8.9 7.1 3 7.7 7.1 1.5 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Hydrophobin_2 PF06766.11 EXF78277.1 - 1.7e-27 95.2 8.8 2.1e-27 94.9 8.8 1.1 1 0 0 1 1 1 1 Fungal hydrophobin Ish1 PF10281.9 EXF78278.1 - 4e-88 289.4 24.2 1.9e-12 47.3 0.0 8.8 8 1 0 8 8 8 8 Putative stress-responsive nuclear envelope protein SAP PF02037.27 EXF78278.1 - 3.3e-09 36.3 0.0 0.83 9.5 0.0 7.1 7 1 0 7 7 7 1 SAP domain Slx4 PF09494.10 EXF78278.1 - 1.9e-05 24.5 1.2 44 4.1 0.0 6.3 7 1 0 7 7 7 0 Slx4 endonuclease HeH PF12949.7 EXF78278.1 - 0.00011 21.8 0.0 1.5 8.6 0.0 5.0 5 0 0 5 5 5 1 HeH/LEM domain SAM_2 PF07647.17 EXF78278.1 - 0.054 13.6 1.4 3.4 7.9 0.1 3.7 4 0 0 4 4 4 0 SAM domain (Sterile alpha motif) LEA_4 PF02987.16 EXF78278.1 - 3 8.0 17.4 2.8 8.1 0.5 4.8 4 0 0 4 4 4 0 Late embryogenesis abundant protein HrpF PF06266.12 EXF78278.1 - 8.6 6.7 12.3 3.2 8.1 1.6 4.7 5 0 0 5 5 5 0 HrpF protein tRNA_lig_CPD PF08302.11 EXF78279.1 - 2.9e-94 315.3 0.0 4.2e-94 314.7 0.0 1.2 1 0 0 1 1 1 1 Fungal tRNA ligase phosphodiesterase domain RNA_lig_T4_1 PF09511.10 EXF78279.1 - 2.8e-85 285.6 0.0 6.9e-85 284.4 0.0 1.7 2 0 0 2 2 2 1 RNA ligase tRNA_lig_kinase PF08303.11 EXF78279.1 - 8.4e-52 175.6 0.0 1.9e-51 174.5 0.0 1.6 1 0 0 1 1 1 1 tRNA ligase kinase domain AAA_18 PF13238.6 EXF78279.1 - 0.011 16.3 0.1 0.1 13.2 0.0 2.7 2 1 0 2 2 2 0 AAA domain Ank_5 PF13857.6 EXF78280.1 - 1.6e-08 34.6 0.0 5.1e-07 29.9 0.0 2.4 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EXF78280.1 - 1.1e-05 25.3 1.0 0.0011 19.3 0.2 3.1 3 0 0 3 3 3 1 Ankyrin repeat Ank_4 PF13637.6 EXF78280.1 - 1.2e-05 25.7 0.0 0.00056 20.4 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EXF78280.1 - 1.4e-05 25.6 0.5 3.3e-05 24.4 0.4 1.7 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.30 EXF78280.1 - 0.0049 17.3 0.1 0.23 12.0 0.1 2.6 2 0 0 2 2 2 1 Ankyrin repeat Ribonuc_P_40 PF08584.11 EXF78281.1 - 3.5e-57 193.9 0.0 4.7e-57 193.4 0.0 1.1 1 0 0 1 1 1 1 Ribonuclease P 40kDa (Rpp40) subunit UPF0020 PF01170.18 EXF78282.1 - 1.7e-09 37.6 0.0 1.1e-07 31.7 0.0 2.2 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 Vac_ImportDeg PF09783.9 EXF78283.1 - 9.7e-70 233.6 0.6 1.2e-69 233.2 0.6 1.1 1 0 0 1 1 1 1 Vacuolar import and degradation protein Mago_nashi PF02792.14 EXF78285.1 - 1.5e-72 242.3 0.1 1.7e-72 242.2 0.1 1.0 1 0 0 1 1 1 1 Mago nashi protein Adaptin_N PF01602.20 EXF78286.1 - 8.6e-97 324.9 10.9 8.6e-97 324.9 10.9 1.6 2 0 0 2 2 2 1 Adaptin N terminal region Coatamer_beta_C PF07718.12 EXF78286.1 - 3.6e-60 201.9 0.6 8.5e-60 200.7 0.6 1.7 1 0 0 1 1 1 1 Coatomer beta C-terminal region Coatomer_b_Cpla PF14806.6 EXF78286.1 - 3.7e-57 191.8 0.0 1.3e-56 190.1 0.0 2.0 1 0 0 1 1 1 1 Coatomer beta subunit appendage platform Cnd1 PF12717.7 EXF78286.1 - 4.2e-13 49.7 7.4 8.5e-11 42.2 0.1 3.0 1 1 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EXF78286.1 - 2.5e-07 31.0 6.7 0.00064 20.1 0.0 4.9 2 1 4 6 6 6 4 HEAT repeats Coatomer_g_Cpla PF16381.5 EXF78286.1 - 0.00046 20.3 0.0 0.0016 18.6 0.0 2.0 1 0 0 1 1 1 1 Coatomer subunit gamma-1 C-terminal appendage platform HEAT PF02985.22 EXF78286.1 - 0.0022 18.1 1.0 4.1 7.9 0.0 4.7 5 0 0 5 5 5 1 HEAT repeat AP4E_app_platf PF14807.6 EXF78286.1 - 0.01 16.1 0.2 0.037 14.4 0.2 2.0 1 0 0 1 1 1 0 Adaptin AP4 complex epsilon appendage platform DUF5578 PF17741.1 EXF78286.1 - 0.021 14.3 3.8 1.8 7.9 0.1 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5578) DUF1380 PF07128.12 EXF78286.1 - 1.3 9.2 5.2 1.1 9.4 0.3 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1380) UBD PF16455.5 EXF78287.1 - 3.9e-38 129.9 0.0 6.5e-38 129.2 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-binding domain ubiquitin PF00240.23 EXF78287.1 - 2.4e-08 33.6 0.0 4.5e-08 32.7 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family DUF2407 PF10302.9 EXF78287.1 - 0.0018 18.8 0.6 0.0051 17.4 0.2 1.9 1 1 1 2 2 2 1 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.6 EXF78287.1 - 0.017 15.2 0.1 0.031 14.4 0.1 1.4 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD PF11976.8 EXF78287.1 - 0.022 14.6 0.0 0.044 13.6 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Glyco_hydro_7 PF00840.20 EXF78288.1 - 2.6e-142 474.6 5.1 4.1e-142 473.9 5.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 7 Pre-SET PF05033.16 EXF78288.1 - 2.5e-18 66.7 5.0 2.5e-18 66.7 5.0 3.5 4 0 0 4 4 4 1 Pre-SET motif SET PF00856.28 EXF78288.1 - 1.4e-17 64.6 0.0 6.6e-17 62.4 0.0 2.2 2 1 0 2 2 2 1 SET domain HET PF06985.11 EXF78289.1 - 9.5e-14 52.0 1.6 2.3e-13 50.7 0.6 2.2 2 0 0 2 2 2 1 Heterokaryon incompatibility protein (HET) HET PF06985.11 EXF78291.1 - 1.9e-13 51.0 1.5 3.4e-13 50.2 1.5 1.5 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Haem_degrading PF03928.14 EXF78292.1 - 1.6e-33 115.3 1.9 3.7e-33 114.1 0.0 2.0 2 0 0 2 2 2 1 Haem-degrading HTH_Tnp_Tc3_2 PF01498.18 EXF78292.1 - 0.13 12.5 0.0 0.3 11.3 0.0 1.6 1 0 0 1 1 1 0 Transposase DUF5580 PF17743.1 EXF78292.1 - 0.23 10.0 0.1 0.34 9.4 0.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5580) SnoaL_4 PF13577.6 EXF78293.1 - 1.1e-17 64.3 1.4 1.3e-17 64.1 1.4 1.1 1 0 0 1 1 1 1 SnoaL-like domain CFEM PF05730.11 EXF78295.1 - 0.0036 17.4 2.8 0.006 16.6 2.8 1.4 1 0 0 1 1 1 1 CFEM domain Ank_2 PF12796.7 EXF78296.1 - 6e-46 154.9 1.3 1.4e-12 48.0 0.0 5.5 3 2 2 5 5 5 5 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EXF78296.1 - 3.9e-39 128.2 0.8 0.00018 21.6 0.0 10.6 10 0 0 10 10 10 9 Ankyrin repeat Ank_4 PF13637.6 EXF78296.1 - 3.9e-38 129.3 0.5 3.3e-09 37.1 0.0 9.1 6 3 4 10 10 10 8 Ankyrin repeats (many copies) Ank_5 PF13857.6 EXF78296.1 - 1.5e-29 101.6 1.1 3.6e-05 24.0 0.0 7.7 5 2 2 7 7 7 5 Ankyrin repeats (many copies) Ank PF00023.30 EXF78296.1 - 3.5e-25 87.3 6.9 0.011 16.2 0.0 9.9 9 1 1 10 10 10 7 Ankyrin repeat NmrA PF05368.13 EXF78297.1 - 1.2e-23 83.9 0.2 1.6e-23 83.5 0.2 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EXF78297.1 - 1.3e-14 54.5 0.0 1.7e-14 54.1 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EXF78297.1 - 0.0002 20.9 0.1 0.00068 19.2 0.0 1.8 1 1 1 2 2 2 1 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.24 EXF78297.1 - 0.0047 17.4 0.2 0.012 16.1 0.0 1.7 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain DapB_N PF01113.20 EXF78297.1 - 0.021 14.9 0.0 0.042 14.0 0.0 1.5 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Shikimate_DH PF01488.20 EXF78297.1 - 0.057 13.5 0.0 0.1 12.6 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase NAD_binding_4 PF07993.12 EXF78297.1 - 0.074 12.2 0.0 0.11 11.6 0.0 1.3 1 0 0 1 1 1 0 Male sterility protein 3Beta_HSD PF01073.19 EXF78297.1 - 0.11 11.5 0.0 0.47 9.4 0.0 1.9 1 1 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family p450 PF00067.22 EXF78298.1 - 1.4e-56 192.1 0.1 1.9e-56 191.7 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 Asn_synthase PF00733.21 EXF78299.1 - 1.6e-66 225.4 0.0 2.3e-66 224.9 0.0 1.2 1 0 0 1 1 1 1 Asparagine synthase GATase_7 PF13537.6 EXF78299.1 - 1.1e-33 115.8 0.0 2.4e-33 114.7 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 EXF78299.1 - 7.2e-32 110.4 0.0 2.1e-31 108.9 0.0 1.8 2 0 0 2 2 2 1 Glutamine amidotransferase domain DUF3700 PF12481.8 EXF78299.1 - 2.5e-06 27.1 0.0 6.9e-06 25.7 0.0 1.7 2 0 0 2 2 2 1 Aluminium induced protein tRNA_Me_trans PF03054.16 EXF78299.1 - 0.022 13.5 0.0 0.037 12.8 0.0 1.3 1 0 0 1 1 1 0 tRNA methyl transferase NAD_synthase PF02540.17 EXF78299.1 - 0.05 12.7 0.0 0.088 11.9 0.0 1.3 1 0 0 1 1 1 0 NAD synthase Raftlin PF15250.6 EXF78300.1 - 0.11 11.2 10.9 0.14 10.9 10.9 1.0 1 0 0 1 1 1 0 Raftlin Zip PF02535.22 EXF78300.1 - 0.29 10.3 5.9 0.35 10.0 5.9 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter Neur_chan_memb PF02932.16 EXF78300.1 - 6.8 6.7 7.1 8.7 6.3 7.1 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region SpoIIIAH PF12685.7 EXF78300.1 - 9.4 6.0 17.5 13 5.5 17.5 1.3 1 0 0 1 1 1 0 SpoIIIAH-like protein MFS_1 PF07690.16 EXF78301.1 - 9.1e-15 54.4 45.1 5.4e-14 51.9 43.6 2.4 1 1 0 1 1 1 1 Major Facilitator Superfamily Phage_holin_3_6 PF07332.11 EXF78301.1 - 0.071 13.2 0.3 0.071 13.2 0.3 3.9 4 1 0 4 4 4 0 Putative Actinobacterial Holin-X, holin superfamily III DUF2304 PF10066.9 EXF78301.1 - 7.4 6.8 9.7 1.2 9.4 3.3 2.9 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2304) Abhydrolase_4 PF08386.10 EXF78303.1 - 4.4e-21 74.9 0.1 1.4e-20 73.3 0.0 1.8 2 0 0 2 2 2 1 TAP-like protein Abhydrolase_1 PF00561.20 EXF78303.1 - 4.9e-12 46.0 0.0 6.9e-09 35.7 0.0 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold Asp PF00026.23 EXF78304.1 - 1.7e-07 31.0 0.0 1.7e-06 27.7 0.0 2.0 1 1 0 1 1 1 1 Eukaryotic aspartyl protease Gram_pos_anchor PF00746.21 EXF78304.1 - 0.043 13.8 0.5 0.12 12.3 0.5 1.8 1 0 0 1 1 1 0 LPXTG cell wall anchor motif TraI_2B PF18340.1 EXF78306.1 - 0.011 15.8 0.2 0.015 15.3 0.2 1.3 1 0 0 1 1 1 0 DNA relaxase TraI 2B/2B-like domain AA_permease_2 PF13520.6 EXF78307.1 - 9.7e-73 245.4 30.6 1.2e-72 245.1 30.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EXF78307.1 - 3.5e-22 78.7 28.3 4.3e-22 78.4 28.3 1.0 1 0 0 1 1 1 1 Amino acid permease DUF1229 PF06797.11 EXF78307.1 - 0.015 15.5 0.1 5.4 7.2 0.0 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1229) TauD PF02668.16 EXF78308.1 - 2.8e-17 63.4 0.0 1.3e-12 48.1 0.0 2.3 2 1 0 2 2 2 2 Taurine catabolism dioxygenase TauD, TfdA family RhoGAP PF00620.27 EXF78308.1 - 0.03 14.2 0.0 0.05 13.4 0.0 1.4 1 0 0 1 1 1 0 RhoGAP domain MFS_1 PF07690.16 EXF78309.1 - 1.2e-23 83.6 15.3 2.2e-17 63.0 7.3 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily 2-Hacid_dh_C PF02826.19 EXF78310.1 - 4e-44 150.1 0.1 5.5e-44 149.7 0.1 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EXF78310.1 - 2.4e-11 43.4 0.0 3.3e-11 43.0 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 EXF78310.1 - 0.00014 22.1 0.0 0.00023 21.4 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase GFO_IDH_MocA PF01408.22 EXF78310.1 - 0.051 14.4 0.0 0.1 13.4 0.0 1.5 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold Nudix_N PF12535.8 EXF78310.1 - 0.13 11.9 0.2 0.29 10.7 0.2 1.5 1 0 0 1 1 1 0 Hydrolase of X-linked nucleoside diphosphate N terminal Glyco_hydro_43 PF04616.14 EXF78311.1 - 4.6e-76 255.9 0.1 6.5e-76 255.4 0.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 p450 PF00067.22 EXF78311.1 - 1.7e-28 99.6 0.0 2.4e-28 99.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 GH43_C2 PF17851.1 EXF78311.1 - 6.2e-18 65.2 0.0 1e-17 64.6 0.0 1.3 1 0 0 1 1 1 1 Beta xylosidase C-terminal Concanavalin A-like domain Abhydrolase_3 PF07859.13 EXF78312.1 - 6.7e-21 75.1 0.1 1.4e-17 64.2 0.1 2.1 1 1 0 2 2 2 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EXF78312.1 - 2.8e-07 30.2 0.0 0.00026 20.5 0.0 2.4 2 0 0 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 EXF78312.1 - 2.4e-06 28.3 5.0 3e-06 28.0 5.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Chlorophyllase PF07224.11 EXF78312.1 - 0.00039 19.5 0.1 0.00068 18.8 0.1 1.3 1 0 0 1 1 1 1 Chlorophyllase Hydrolase_4 PF12146.8 EXF78312.1 - 0.0093 15.2 0.0 0.033 13.4 0.0 1.8 1 1 0 1 1 1 1 Serine aminopeptidase, S33 DLH PF01738.18 EXF78312.1 - 0.016 14.7 0.0 0.077 12.5 0.0 1.9 2 0 0 2 2 2 0 Dienelactone hydrolase family Abhydrolase_4 PF08386.10 EXF78312.1 - 0.048 13.8 0.0 0.12 12.6 0.0 1.6 1 0 0 1 1 1 0 TAP-like protein Abhydrolase_2 PF02230.16 EXF78312.1 - 0.054 13.3 0.0 1.2 8.9 0.0 2.3 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase p450 PF00067.22 EXF78313.1 - 7.2e-59 199.7 0.0 9.9e-59 199.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 adh_short PF00106.25 EXF78314.1 - 2.5e-12 46.7 0.1 3.1e-12 46.4 0.1 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF78314.1 - 4e-07 29.8 0.0 5e-07 29.5 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF78314.1 - 0.00036 20.5 0.1 0.00042 20.3 0.1 1.1 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 EXF78314.1 - 0.048 13.5 0.6 0.17 11.8 0.6 1.8 1 1 0 1 1 1 0 NAD(P)H-binding 4HBT_2 PF13279.6 EXF78315.1 - 1.6e-09 38.3 0.0 3.4e-09 37.3 0.0 1.5 2 0 0 2 2 2 1 Thioesterase-like superfamily 4HBT PF03061.22 EXF78315.1 - 0.057 13.8 0.0 0.12 12.7 0.0 1.5 1 0 0 1 1 1 0 Thioesterase superfamily His_Phos_2 PF00328.22 EXF78316.1 - 3.3e-24 86.0 0.0 4.3e-24 85.6 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) NAD_binding_8 PF13450.6 EXF78317.1 - 0.00035 20.7 0.0 0.0007 19.8 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 EXF78317.1 - 0.0016 17.8 0.0 0.011 15.1 0.0 1.9 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.14 EXF78317.1 - 0.021 14.0 0.0 0.051 12.8 0.0 1.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EXF78317.1 - 0.077 12.0 0.0 0.11 11.5 0.0 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein Trp_halogenase PF04820.14 EXF78317.1 - 0.11 11.3 0.0 0.17 10.7 0.0 1.3 1 0 0 1 1 1 0 Tryptophan halogenase AA_permease_2 PF13520.6 EXF78318.1 - 3.1e-63 214.1 45.6 3.9e-63 213.8 45.6 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EXF78318.1 - 5.3e-13 48.4 40.6 7e-13 48.0 40.6 1.1 1 0 0 1 1 1 1 Amino acid permease PHO4 PF01384.20 EXF78321.1 - 3.6e-110 368.2 9.9 4.2e-110 368.0 9.9 1.0 1 0 0 1 1 1 1 Phosphate transporter family Tim17 PF02466.19 EXF78321.1 - 0.0034 17.8 2.3 0.011 16.1 0.1 2.9 2 1 0 2 2 2 1 Tim17/Tim22/Tim23/Pmp24 family Glycophorin_A PF01102.18 EXF78321.1 - 0.069 13.4 0.0 0.16 12.2 0.0 1.6 1 0 0 1 1 1 0 Glycophorin A FAD_binding_3 PF01494.19 EXF78322.1 - 3.5e-06 26.5 0.0 4.7e-06 26.1 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain IGPS PF00218.21 EXF78322.1 - 0.064 12.4 0.0 0.089 11.9 0.0 1.2 1 0 0 1 1 1 0 Indole-3-glycerol phosphate synthase DUF3108 PF11306.8 EXF78322.1 - 0.1 12.5 0.1 0.14 12.1 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3108) Csm4_C PF17953.1 EXF78322.1 - 0.14 12.0 0.0 0.3 10.9 0.0 1.5 1 1 0 1 1 1 0 CRISPR Csm4 C-terminal domain MutS_III PF05192.18 EXF78323.1 - 0.028 14.6 0.1 0.047 13.9 0.1 1.3 1 0 0 1 1 1 0 MutS domain III DUF4796 PF16044.5 EXF78323.1 - 0.048 13.2 0.0 0.082 12.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4796) SOG2 PF10428.9 EXF78323.1 - 1.7 7.8 12.2 2.6 7.1 12.2 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein Cwf_Cwc_15 PF04889.12 EXF78323.1 - 8.1 6.1 17.6 1.8 8.2 3.9 2.2 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein LysM PF01476.20 EXF78325.1 - 3.4e-12 46.2 0.0 3.5e-07 30.2 0.0 2.4 2 0 0 2 2 2 2 LysM domain HPP PF04982.13 EXF78325.1 - 0.031 14.4 0.1 0.095 12.9 0.1 1.8 1 0 0 1 1 1 0 HPP family PSP PF04046.16 EXF78325.1 - 0.15 12.0 0.1 0.68 9.8 0.0 2.1 2 0 0 2 2 2 0 PSP Glyco_hydro_18 PF00704.28 EXF78326.1 - 9.3e-69 232.5 2.1 9.3e-69 232.5 2.1 1.6 2 0 0 2 2 2 1 Glycosyl hydrolases family 18 Chitin_bind_1 PF00187.19 EXF78326.1 - 1.7e-07 31.6 14.3 1.7e-07 31.6 14.3 3.8 5 1 0 5 5 5 1 Chitin recognition protein Glyco_hydro_85 PF03644.13 EXF78326.1 - 0.0019 17.7 0.0 0.005 16.3 0.0 1.7 1 0 0 1 1 1 1 Glycosyl hydrolase family 85 KASH_CCD PF14662.6 EXF78328.1 - 6.7e-06 26.1 75.8 0.00046 20.1 18.2 6.3 2 2 3 6 6 6 4 Coiled-coil region of CCDC155 or KASH APG6_N PF17675.1 EXF78328.1 - 1.5e-05 25.5 14.9 1.5e-05 25.5 14.9 6.3 3 3 3 6 6 5 2 Apg6 coiled-coil region Spc7 PF08317.11 EXF78328.1 - 0.00031 19.7 15.9 0.00031 19.7 15.9 5.6 2 1 3 5 5 5 4 Spc7 kinetochore protein DUF3450 PF11932.8 EXF78328.1 - 0.00037 19.9 6.7 0.00037 19.9 6.7 6.9 3 3 3 6 6 6 3 Protein of unknown function (DUF3450) HALZ PF02183.18 EXF78328.1 - 0.0006 20.0 49.9 0.11 12.7 0.0 11.4 8 4 4 12 12 12 3 Homeobox associated leucine zipper MAD PF05557.13 EXF78328.1 - 0.0022 16.5 24.1 0.0022 16.5 24.1 3.6 2 1 2 4 4 4 1 Mitotic checkpoint protein CENP-F_leu_zip PF10473.9 EXF78328.1 - 0.0094 16.0 19.1 0.0094 16.0 19.1 7.8 2 2 5 7 7 7 4 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Prp19 PF08606.11 EXF78328.1 - 0.0099 15.8 0.2 9.3 6.3 0.0 3.6 2 1 0 2 2 2 1 Prp19/Pso4-like TPR_MLP1_2 PF07926.12 EXF78328.1 - 0.01 15.9 11.5 0.01 15.9 11.5 7.9 2 2 3 5 5 4 0 TPR/MLP1/MLP2-like protein TSC22 PF01166.18 EXF78328.1 - 0.024 15.0 0.5 0.024 15.0 0.5 8.1 8 4 4 12 12 10 0 TSC-22/dip/bun family GAS PF13851.6 EXF78328.1 - 0.14 11.4 64.1 0.11 11.8 5.3 5.0 2 1 2 4 4 4 0 Growth-arrest specific micro-tubule binding SHE3 PF17078.5 EXF78328.1 - 1.2 8.8 61.3 0.017 14.8 6.1 6.5 2 2 4 6 6 6 0 SWI5-dependent HO expression protein 3 ZapB PF06005.12 EXF78328.1 - 3.1 8.3 76.6 0.24 11.9 1.5 10.1 3 3 5 8 8 7 0 Cell division protein ZapB JIP_LZII PF16471.5 EXF78328.1 - 3.9 7.7 72.8 0.38 11.0 4.6 10.2 4 3 3 8 8 7 0 JNK-interacting protein leucine zipper II HOOK PF05622.12 EXF78328.1 - 4 5.5 79.3 3 5.9 2.7 3.4 2 1 1 3 3 3 0 HOOK protein CFEM PF05730.11 EXF78329.1 - 4e-12 46.1 10.9 1.3e-11 44.4 10.9 1.9 1 0 0 1 1 1 1 CFEM domain Cupin_1 PF00190.22 EXF78331.1 - 2.3e-40 137.7 0.0 1.3e-20 73.5 0.0 2.2 2 0 0 2 2 2 2 Cupin Cupin_2 PF07883.11 EXF78331.1 - 8.7e-26 89.4 0.7 2.8e-13 49.4 0.1 2.4 2 0 0 2 2 2 2 Cupin domain AraC_binding PF02311.19 EXF78331.1 - 1.6e-07 31.3 0.2 0.00048 20.0 0.1 2.4 2 0 0 2 2 2 2 AraC-like ligand binding domain Cupin_3 PF05899.12 EXF78331.1 - 3e-07 30.0 0.0 0.017 14.8 0.0 2.6 2 0 0 2 2 2 2 Protein of unknown function (DUF861) MannoseP_isomer PF01050.18 EXF78331.1 - 0.00024 21.0 0.0 0.038 13.9 0.0 2.2 2 0 0 2 2 2 2 Mannose-6-phosphate isomerase ARD PF03079.14 EXF78331.1 - 0.0014 18.8 0.2 0.12 12.5 0.1 2.4 2 0 0 2 2 2 1 ARD/ARD' family 3-HAO PF06052.12 EXF78331.1 - 0.094 12.4 0.0 1 9.0 0.0 2.1 2 0 0 2 2 2 0 3-hydroxyanthranilic acid dioxygenase Sulfate_transp PF00916.20 EXF78332.1 - 3.9e-86 289.2 20.4 6e-86 288.6 20.4 1.3 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 EXF78332.1 - 1.5e-12 47.2 0.0 2.7e-12 46.3 0.0 1.4 1 0 0 1 1 1 1 STAS domain ZapB PF06005.12 EXF78333.1 - 0.48 10.9 12.2 22 5.6 8.7 3.2 2 1 0 2 2 2 0 Cell division protein ZapB bZIP_1 PF00170.21 EXF78333.1 - 1.3 9.2 6.8 3.2 7.9 0.1 2.7 3 0 0 3 3 3 0 bZIP transcription factor Fungal_TACC PF12709.7 EXF78334.1 - 0.022 15.2 1.2 0.23 12.0 0.2 2.2 2 0 0 2 2 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins HIP1_clath_bdg PF16515.5 EXF78334.1 - 0.11 13.1 7.0 0.67 10.6 1.4 2.0 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Enkurin PF13864.6 EXF78334.1 - 0.21 12.0 3.6 7.2 7.1 0.6 2.2 1 1 1 2 2 2 0 Calmodulin-binding TMPIT PF07851.13 EXF78334.1 - 0.36 10.0 1.0 0.44 9.7 1.0 1.1 1 0 0 1 1 1 0 TMPIT-like protein FAM184 PF15665.5 EXF78334.1 - 0.38 10.5 8.1 2.6 7.8 8.1 1.8 1 1 0 1 1 1 0 Family with sequence similarity 184, A and B DUF4527 PF15030.6 EXF78335.1 - 0.0011 18.5 4.8 0.002 17.6 4.8 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF4527) DivIC PF04977.15 EXF78335.1 - 0.018 14.8 8.0 0.018 14.8 8.0 2.7 2 1 1 3 3 3 0 Septum formation initiator kleA_kleC PF17383.2 EXF78335.1 - 1.1 9.6 6.0 0.87 10.0 2.2 2.4 1 1 2 3 3 3 0 Uncharacterized KorC regulated protein A TolA_bind_tri PF16331.5 EXF78335.1 - 1.3 9.2 13.9 4 7.6 7.1 2.5 2 0 0 2 2 2 0 TolA binding protein trimerisation Spc7 PF08317.11 EXF78335.1 - 1.9 7.3 21.2 1.2 8.0 9.8 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF4407 PF14362.6 EXF78335.1 - 5.5 6.2 15.7 7.4 5.8 15.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) HIP1_clath_bdg PF16515.5 EXF78335.1 - 8.8 7.0 19.6 0.69 10.6 8.9 2.3 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Nop52 PF05997.12 EXF78336.1 - 1.2e-58 198.5 0.3 1.5e-58 198.1 0.3 1.1 1 0 0 1 1 1 1 Nucleolar protein,Nop52 DUF416 PF04222.12 EXF78336.1 - 0.07 12.5 0.4 0.07 12.5 0.4 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF416) DAGK_cat PF00781.24 EXF78337.1 - 8.1e-25 86.9 0.0 1.9e-24 85.7 0.0 1.7 2 0 0 2 2 2 1 Diacylglycerol kinase catalytic domain PRKCSH-like PF12999.7 EXF78337.1 - 0.028 14.2 0.0 0.047 13.5 0.0 1.3 1 0 0 1 1 1 0 Glucosidase II beta subunit-like Glycos_transf_3 PF00591.21 EXF78338.1 - 1.2e-63 215.1 0.0 1.8e-63 214.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family, a/b domain Glycos_trans_3N PF02885.17 EXF78338.1 - 3e-09 36.6 0.0 7e-09 35.4 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferase family, helical bundle domain NARP1 PF12569.8 EXF78339.1 - 1.7e-190 634.3 25.1 7.1e-189 629.0 19.6 2.2 2 0 0 2 2 2 2 NMDA receptor-regulated protein 1 Cid2 PF09774.9 EXF78339.1 - 1.7e-53 181.3 0.0 1.7e-53 181.3 0.0 2.5 3 0 0 3 3 2 1 Caffeine-induced death protein 2 TPR_19 PF14559.6 EXF78339.1 - 7.2e-19 68.1 24.2 0.00017 22.0 4.0 7.3 7 1 0 7 7 6 4 Tetratricopeptide repeat TPR_16 PF13432.6 EXF78339.1 - 2.4e-15 56.9 33.5 0.027 15.1 0.2 10.4 9 1 2 11 11 9 6 Tetratricopeptide repeat ANAPC3 PF12895.7 EXF78339.1 - 1.2e-11 44.7 19.3 9.5e-06 25.8 2.1 5.4 4 2 2 6 6 6 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.17 EXF78339.1 - 2.9e-09 36.3 41.5 0.00028 20.8 0.3 10.6 12 0 0 12 12 11 3 Tetratricopeptide repeat TPR_1 PF00515.28 EXF78339.1 - 5e-08 32.4 18.4 3.1e-05 23.6 0.5 7.6 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_14 PF13428.6 EXF78339.1 - 4.4e-07 30.2 30.0 0.013 16.3 0.0 10.6 8 3 4 12 12 10 2 Tetratricopeptide repeat TPR_11 PF13414.6 EXF78339.1 - 1e-06 28.3 16.3 0.00011 21.9 0.1 6.7 7 0 0 7 7 7 1 TPR repeat TPR_9 PF13371.6 EXF78339.1 - 2.6e-06 27.5 14.0 0.0013 18.8 0.3 6.6 7 1 1 8 8 6 1 Tetratricopeptide repeat TPR_12 PF13424.6 EXF78339.1 - 5.1e-06 26.7 28.6 0.07 13.4 0.4 8.4 7 1 2 9 9 9 5 Tetratricopeptide repeat TPR_17 PF13431.6 EXF78339.1 - 6.5e-05 23.0 14.2 0.89 10.1 0.0 7.6 9 0 0 9 9 7 2 Tetratricopeptide repeat TPR_MalT PF17874.1 EXF78339.1 - 0.00029 20.3 11.5 0.11 11.8 0.1 3.3 2 1 1 3 3 3 3 MalT-like TPR region TPR_8 PF13181.6 EXF78339.1 - 0.00052 20.0 17.2 0.0013 18.8 0.2 6.6 7 0 0 7 7 7 1 Tetratricopeptide repeat NRDE-2 PF08424.10 EXF78339.1 - 0.0011 18.1 0.1 0.0035 16.5 0.1 1.8 1 0 0 1 1 1 1 NRDE-2, necessary for RNA interference TPR_3 PF07720.12 EXF78339.1 - 0.07 13.2 2.0 1.3 9.1 0.2 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat Sel1 PF08238.12 EXF78339.1 - 0.089 13.5 1.8 9.8 7.0 0.0 3.0 2 0 0 2 2 2 0 Sel1 repeat TPR_7 PF13176.6 EXF78339.1 - 0.19 11.8 9.2 16 5.8 0.1 6.0 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_6 PF13174.6 EXF78339.1 - 0.36 11.6 22.9 8.4 7.3 0.1 8.1 9 0 0 9 9 6 0 Tetratricopeptide repeat TPR_4 PF07721.14 EXF78339.1 - 0.48 11.2 9.8 11 6.9 0.1 5.8 7 0 0 7 7 4 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EXF78339.1 - 0.67 10.1 11.0 18 5.5 0.2 5.0 5 0 0 5 5 5 0 Fis1 C-terminal tetratricopeptide repeat Ank_2 PF12796.7 EXF78340.1 - 6.2e-61 203.0 1.4 1.4e-10 41.6 0.0 6.7 3 1 2 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EXF78340.1 - 1.7e-47 159.2 7.0 3e-07 30.8 0.0 10.1 6 2 5 11 11 11 9 Ankyrin repeats (many copies) Ank_5 PF13857.6 EXF78340.1 - 1.1e-42 143.5 9.7 1.3e-08 35.0 0.0 10.1 6 2 4 10 10 10 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 EXF78340.1 - 6.1e-42 136.8 11.4 0.00081 19.7 0.0 13.3 14 0 0 14 14 14 10 Ankyrin repeat Ank PF00023.30 EXF78340.1 - 1.7e-36 123.0 19.1 0.00065 20.0 0.4 13.4 12 1 0 12 12 12 10 Ankyrin repeat DUF1688 PF07958.11 EXF78342.1 - 5.5e-174 578.8 0.0 6.2e-174 578.6 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1688) Q_salvage PF10343.9 EXF78342.1 - 3.9e-05 23.4 0.0 0.032 13.8 0.0 2.2 2 0 0 2 2 2 2 Potential Queuosine, Q, salvage protein family HET PF06985.11 EXF78343.1 - 8e-21 74.9 0.0 2.1e-20 73.6 0.0 1.7 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Glyco_hydro_43 PF04616.14 EXF78344.1 - 5.6e-72 242.5 2.2 7.7e-72 242.0 2.2 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 GH43_C2 PF17851.1 EXF78344.1 - 9.4e-09 35.3 0.0 4.8e-05 23.2 0.0 2.5 1 1 1 2 2 2 2 Beta xylosidase C-terminal Concanavalin A-like domain DUF5005 PF16396.5 EXF78344.1 - 0.036 12.8 0.0 0.22 10.1 0.0 2.1 3 0 0 3 3 3 0 Domain of unknown function (DUF5005) Glyco_hydro_32N PF00251.20 EXF78344.1 - 0.037 13.6 1.2 0.046 13.3 0.0 1.7 2 0 0 2 2 2 0 Glycosyl hydrolases family 32 N-terminal domain Zn_clus PF00172.18 EXF78345.1 - 0.012 15.7 5.4 0.02 15.0 5.4 1.3 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Glutaminase PF04960.15 EXF78346.1 - 8.6e-112 373.0 0.1 1.1e-111 372.6 0.1 1.1 1 0 0 1 1 1 1 Glutaminase 2-Hacid_dh_C PF02826.19 EXF78347.1 - 2.2e-56 190.0 0.0 3e-56 189.6 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EXF78347.1 - 2.7e-13 49.7 0.0 3.7e-13 49.3 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 EXF78347.1 - 3.1e-07 30.7 0.0 5.2e-07 30.0 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 EXF78347.1 - 0.0038 17.8 0.0 0.0099 16.4 0.0 1.7 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent IlvN PF07991.12 EXF78347.1 - 0.0071 15.9 0.0 0.011 15.3 0.0 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain AlaDh_PNT_C PF01262.21 EXF78347.1 - 0.056 12.7 0.0 0.15 11.3 0.0 1.6 1 1 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain AdoHcyase PF05221.17 EXF78348.1 - 3e-131 437.0 0.0 1.3e-74 251.0 0.2 2.0 1 1 1 2 2 2 2 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.21 EXF78348.1 - 5.5e-83 276.9 2.2 8.9e-83 276.2 2.2 1.3 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.19 EXF78348.1 - 1.2e-06 28.0 0.2 7.6e-06 25.4 0.1 2.2 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TrkA_N PF02254.18 EXF78348.1 - 0.006 16.8 0.0 0.013 15.8 0.0 1.6 1 0 0 1 1 1 1 TrkA-N domain ELFV_dehydrog PF00208.21 EXF78348.1 - 0.0061 16.3 0.1 0.011 15.5 0.1 1.5 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase IlvN PF07991.12 EXF78348.1 - 0.0086 15.7 0.2 0.017 14.7 0.2 1.4 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain 3HCDH_N PF02737.18 EXF78348.1 - 0.055 13.4 0.2 0.1 12.5 0.2 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Urocanase PF01175.18 EXF78348.1 - 0.13 11.9 0.3 0.22 11.1 0.3 1.3 1 0 0 1 1 1 0 Urocanase Rossmann-like domain JAB PF01398.21 EXF78349.1 - 3.6e-09 36.6 1.3 1.9e-07 31.0 1.3 2.3 1 1 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Amidase PF01425.21 EXF78350.1 - 0.059 12.3 0.0 0.081 11.9 0.0 1.2 1 0 0 1 1 1 0 Amidase SepA PF17080.5 EXF78350.1 - 0.14 12.6 0.0 0.2 12.0 0.0 1.2 1 0 0 1 1 1 0 Multidrug Resistance efflux pump Mito_carr PF00153.27 EXF78351.1 - 3.9e-48 161.3 3.7 5e-20 71.2 0.0 3.9 3 1 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 EXF78351.1 - 0.013 14.7 1.4 0.066 12.4 0.3 2.2 2 0 0 2 2 2 0 Gammaproteobacterial serine protease GATase PF00117.28 EXF78352.1 - 1.7e-36 125.8 0.0 5.3e-36 124.2 0.0 1.7 2 0 0 2 2 2 1 Glutamine amidotransferase class-I GMP_synt_C PF00958.22 EXF78352.1 - 3.2e-35 120.1 0.0 6e-35 119.2 0.0 1.5 1 0 0 1 1 1 1 GMP synthase C terminal domain NAD_synthase PF02540.17 EXF78352.1 - 5.2e-08 32.3 0.0 1.4e-05 24.3 0.0 2.2 2 0 0 2 2 2 2 NAD synthase Peptidase_C26 PF07722.13 EXF78352.1 - 4.8e-06 26.5 0.0 9.7e-06 25.5 0.0 1.5 1 0 0 1 1 1 1 Peptidase C26 QueC PF06508.13 EXF78352.1 - 0.0029 17.2 0.0 0.086 12.3 0.0 2.2 2 0 0 2 2 2 1 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.16 EXF78352.1 - 0.004 16.0 0.1 0.0098 14.7 0.1 1.6 2 0 0 2 2 2 1 tRNA methyl transferase PAPS_reduct PF01507.19 EXF78352.1 - 0.032 14.3 0.0 0.05 13.6 0.0 1.3 1 0 0 1 1 1 0 Phosphoadenosine phosphosulfate reductase family ThiI PF02568.14 EXF78352.1 - 0.047 13.3 0.0 0.12 11.9 0.0 1.6 2 0 0 2 2 2 0 Thiamine biosynthesis protein (ThiI) DUF2732 PF10809.8 EXF78352.1 - 0.083 12.8 0.0 0.24 11.3 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2732) ATP_bind_3 PF01171.20 EXF78352.1 - 0.092 12.5 0.0 0.29 10.9 0.0 1.8 2 0 0 2 2 2 0 PP-loop family Arginosuc_synth PF00764.19 EXF78352.1 - 0.13 11.6 0.1 0.32 10.2 0.1 1.6 2 0 0 2 2 2 0 Arginosuccinate synthase NO_synthase PF02898.15 EXF78353.1 - 7e-94 314.8 0.0 8.5e-91 304.7 0.0 2.2 2 0 0 2 2 2 2 Nitric oxide synthase, oxygenase domain Flavodoxin_1 PF00258.25 EXF78353.1 - 2.2e-10 40.9 0.0 1.1e-09 38.6 0.0 2.2 2 0 0 2 2 2 1 Flavodoxin FAD_binding_1 PF00667.20 EXF78353.1 - 2.8e-05 23.8 0.0 0.0009 18.9 0.0 2.2 2 0 0 2 2 2 1 FAD binding domain NAD_binding_1 PF00175.21 EXF78353.1 - 0.0021 18.7 0.0 0.0056 17.3 0.0 1.7 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain DUF1707 PF08044.11 EXF78353.1 - 0.017 15.2 0.9 0.1 12.6 0.4 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF1707) ChAPs PF09295.10 EXF78355.1 - 1.7e-153 511.3 0.0 2.2e-153 511.0 0.0 1.1 1 0 0 1 1 1 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_14 PF13428.6 EXF78355.1 - 1.4e-06 28.6 0.9 0.19 12.7 0.4 4.7 3 1 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 EXF78355.1 - 4.6e-05 23.2 0.5 0.055 13.6 0.6 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.6 EXF78355.1 - 4.7e-05 23.4 0.6 0.015 15.4 0.1 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 EXF78355.1 - 5.5e-05 22.9 0.4 0.4 10.8 0.0 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 EXF78355.1 - 0.00041 20.3 0.1 0.13 12.5 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 EXF78355.1 - 0.00068 20.1 0.0 1.5 9.4 0.0 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 EXF78355.1 - 0.0063 16.3 0.3 3.9 7.5 0.1 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 EXF78355.1 - 0.02 15.1 1.1 9.1 6.7 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 EXF78355.1 - 0.022 15.3 0.2 32 5.4 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EXF78355.1 - 0.1 12.8 1.0 15 5.9 0.0 3.7 3 1 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 EXF78356.1 - 0.031 14.0 0.1 48 3.8 0.0 4.0 4 0 0 4 4 4 0 TPR repeat TPR_17 PF13431.6 EXF78356.1 - 0.063 13.7 0.2 19 5.9 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 EXF78356.1 - 0.069 13.8 6.7 5 7.8 0.5 4.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 EXF78356.1 - 7 7.8 17.7 7.7 7.6 0.2 5.4 5 0 0 5 5 5 0 Tetratricopeptide repeat DSS1_SEM1 PF05160.13 EXF78357.1 - 7.6e-24 83.5 12.1 7.6e-24 83.5 12.1 1.4 1 1 0 1 1 1 1 DSS1/SEM1 family Cwf_Cwc_15 PF04889.12 EXF78357.1 - 0.072 12.8 9.6 0.076 12.7 9.6 1.0 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein PGK PF00162.19 EXF78358.1 - 1e-151 505.2 1.7 1.2e-151 505.0 1.7 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase PA PF02225.22 EXF78358.1 - 0.00036 20.5 0.1 0.059 13.4 0.0 3.5 3 1 1 4 4 4 1 PA domain Mpv17_PMP22 PF04117.12 EXF78359.1 - 2.4e-20 72.5 2.6 4.2e-20 71.7 0.1 2.4 3 0 0 3 3 3 1 Mpv17 / PMP22 family Glyco_hydro_53 PF07745.13 EXF78360.1 - 3.3e-75 253.2 0.0 4e-75 252.9 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 53 CwfJ_C_2 PF04676.14 EXF78361.1 - 2.3e-27 95.7 0.1 2.3e-27 95.7 0.1 2.5 2 0 0 2 2 2 1 Protein similar to CwfJ C-terminus 2 CwfJ_C_1 PF04677.15 EXF78361.1 - 1.9e-26 92.3 0.0 3.2e-26 91.6 0.0 1.4 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 FumaraseC_C PF10415.9 EXF78361.1 - 0.1 13.1 0.2 4.3 7.8 0.1 2.7 2 0 0 2 2 2 0 Fumarase C C-terminus ATP_bind_1 PF03029.17 EXF78362.1 - 2.7e-72 243.5 0.0 3.5e-72 243.1 0.0 1.1 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_24 PF13479.6 EXF78362.1 - 4.3e-05 23.3 0.0 7.9e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain GTP_EFTU PF00009.27 EXF78362.1 - 8.1e-05 22.2 0.0 0.012 15.2 0.0 2.7 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EXF78362.1 - 0.00029 20.9 0.0 0.0056 16.8 0.0 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase MeaB PF03308.16 EXF78362.1 - 0.00041 19.4 0.1 0.12 11.4 0.0 2.4 2 1 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_16 PF13191.6 EXF78362.1 - 0.00057 20.3 0.0 0.0012 19.2 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_30 PF13604.6 EXF78362.1 - 0.0014 18.4 0.0 0.0025 17.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain PRK PF00485.18 EXF78362.1 - 0.0016 18.2 0.0 0.0036 17.1 0.0 1.6 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family Zeta_toxin PF06414.12 EXF78362.1 - 0.0017 17.7 0.0 0.0042 16.4 0.0 1.6 1 0 0 1 1 1 1 Zeta toxin AAA_22 PF13401.6 EXF78362.1 - 0.0019 18.5 0.0 0.0063 16.8 0.0 2.0 3 0 0 3 3 1 1 AAA domain NACHT PF05729.12 EXF78362.1 - 0.0025 17.7 0.0 0.0045 16.9 0.0 1.4 1 0 0 1 1 1 1 NACHT domain NB-ARC PF00931.22 EXF78362.1 - 0.0029 16.8 0.0 0.008 15.4 0.0 1.6 2 0 0 2 2 2 1 NB-ARC domain cobW PF02492.19 EXF78362.1 - 0.003 17.2 0.2 0.039 13.6 0.2 2.3 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain G-alpha PF00503.20 EXF78362.1 - 0.0034 16.6 0.0 0.12 11.5 0.0 2.3 2 0 0 2 2 2 1 G-protein alpha subunit AAA_33 PF13671.6 EXF78362.1 - 0.0038 17.4 0.1 0.024 14.8 0.0 2.4 3 0 0 3 3 2 1 AAA domain SRP54 PF00448.22 EXF78362.1 - 0.006 16.2 0.0 0.028 14.0 0.0 2.1 3 0 0 3 3 3 1 SRP54-type protein, GTPase domain FeoB_N PF02421.18 EXF78362.1 - 0.0062 16.1 0.1 0.12 11.9 0.0 2.4 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EXF78362.1 - 0.011 15.7 0.1 8.8 6.2 0.0 2.9 3 0 0 3 3 3 0 RsgA GTPase ATPase_2 PF01637.18 EXF78362.1 - 0.013 15.4 0.1 0.033 14.1 0.0 1.7 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea Roc PF08477.13 EXF78362.1 - 0.014 15.6 0.0 2.8 8.2 0.0 2.5 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EXF78362.1 - 0.016 14.7 0.0 3.2 7.2 0.0 2.4 2 0 0 2 2 2 0 ADP-ribosylation factor family Ras PF00071.22 EXF78362.1 - 0.016 14.8 0.0 1.9 8.1 0.0 2.7 3 0 0 3 3 3 0 Ras family AAA_18 PF13238.6 EXF78362.1 - 0.018 15.6 2.1 0.1 13.2 0.0 2.6 2 0 0 2 2 2 0 AAA domain Pox_A32 PF04665.12 EXF78362.1 - 0.034 13.6 0.2 0.41 10.1 0.0 2.5 3 0 0 3 3 3 0 Poxvirus A32 protein KAP_NTPase PF07693.14 EXF78362.1 - 0.06 12.6 0.0 0.094 11.9 0.0 1.6 1 1 0 1 1 1 0 KAP family P-loop domain DUF87 PF01935.17 EXF78362.1 - 0.069 13.2 0.1 1.5 8.9 0.0 2.3 2 0 0 2 2 2 0 Helicase HerA, central domain SRPRB PF09439.10 EXF78362.1 - 0.08 12.4 0.1 7.8 5.9 0.0 2.3 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit TsaE PF02367.17 EXF78362.1 - 0.089 12.8 0.0 0.19 11.8 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_14 PF13173.6 EXF78362.1 - 0.13 12.3 0.0 0.34 10.9 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 EXF78362.1 - 0.14 12.7 0.1 1.4 9.4 0.0 2.1 2 0 0 2 2 2 0 AAA domain Viral_helicase1 PF01443.18 EXF78362.1 - 0.17 11.6 0.0 0.27 10.9 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase BNIP2 PF12496.8 EXF78362.1 - 8.5 6.8 8.5 21 5.6 8.1 1.7 1 1 0 1 1 1 0 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 DNA_RNApol_7kD PF03604.13 EXF78363.1 - 3.6e-15 55.3 8.1 4.6e-15 55.0 8.1 1.1 1 0 0 1 1 1 1 DNA directed RNA polymerase, 7 kDa subunit GATA PF00320.27 EXF78363.1 - 0.0026 17.3 0.1 0.0026 17.3 0.1 2.2 2 1 0 2 2 2 1 GATA zinc finger Zn-ribbon_8 PF09723.10 EXF78363.1 - 0.0079 16.3 2.2 0.013 15.6 2.2 1.4 1 0 0 1 1 1 1 Zinc ribbon domain HypA PF01155.19 EXF78363.1 - 0.014 15.4 0.4 0.014 15.4 0.4 1.1 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA GFA PF04828.14 EXF78363.1 - 0.015 15.6 1.6 2.9 8.3 0.4 2.1 1 1 1 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme Zn_ribbon_SprT PF17283.2 EXF78363.1 - 0.081 12.8 3.3 0.14 12.1 3.3 1.4 1 0 0 1 1 1 0 SprT-like zinc ribbon domain FYDLN_acid PF09538.10 EXF78363.1 - 0.21 12.3 0.7 0.28 11.9 0.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) zf_UBZ PF18439.1 EXF78363.1 - 0.62 9.7 3.2 9.3 5.9 0.1 2.2 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger TF_Zn_Ribbon PF08271.12 EXF78363.1 - 0.74 9.4 6.5 0.93 9.1 0.1 2.2 1 1 2 3 3 2 0 TFIIB zinc-binding HIT PF01230.23 EXF78364.1 - 3.9e-18 66.0 0.0 6.1e-18 65.4 0.0 1.3 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 EXF78364.1 - 1.4e-05 25.5 0.0 2.8e-05 24.6 0.0 1.4 2 0 0 2 2 2 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.15 EXF78364.1 - 2.5e-05 24.1 0.0 7.3e-05 22.6 0.0 1.7 2 0 0 2 2 2 1 Protein similar to CwfJ C-terminus 1 DUF2267 PF10025.9 EXF78364.1 - 0.087 13.1 0.2 0.19 12.0 0.2 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2267) Aldo_ket_red PF00248.21 EXF78365.1 - 3.3e-48 164.4 0.0 2e-46 158.5 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family Iso_dh PF00180.20 EXF78367.1 - 6.2e-118 393.9 0.0 1.1e-117 393.2 0.0 1.4 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase ATP-synt_ab PF00006.25 EXF78367.1 - 1.6e-108 361.3 0.0 2.5e-108 360.6 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_Xtn PF16886.5 EXF78367.1 - 6.9e-47 158.3 0.0 1.5e-46 157.2 0.0 1.6 1 0 0 1 1 1 1 ATPsynthase alpha/beta subunit N-term extension ATP-synt_ab_N PF02874.23 EXF78367.1 - 6.4e-15 55.4 2.8 1.6e-14 54.1 2.8 1.8 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain LPD23 PF18838.1 EXF78367.1 - 0.16 11.8 0.1 0.37 10.6 0.1 1.6 1 0 0 1 1 1 0 Large polyvalent protein associated domain 23 DUF4061 PF13270.6 EXF78367.1 - 0.23 11.8 0.6 0.52 10.7 0.6 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4061) DUF4048 PF13257.6 EXF78368.1 - 1.7e-14 54.3 0.2 1.7e-14 54.3 0.2 4.7 4 1 1 6 6 6 3 Domain of unknown function (DUF4048) DNA_ligase_A_M PF01068.21 EXF78369.1 - 1.1e-23 84.0 0.1 1.9e-23 83.2 0.1 1.3 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 EXF78369.1 - 3.3e-22 79.6 0.0 1.2e-21 77.8 0.0 1.8 2 0 0 2 2 2 1 DNA ligase N terminus RNA_ligase PF09414.10 EXF78369.1 - 2.2e-06 28.1 0.0 4.7e-06 27.0 0.0 1.5 1 0 0 1 1 1 1 RNA ligase DIOX_N PF14226.6 EXF78370.1 - 2.1e-22 80.1 0.0 3.3e-22 79.5 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EXF78370.1 - 1.2e-13 51.3 0.0 2.6e-13 50.3 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily MKT1_C PF12246.8 EXF78371.1 - 4.1e-74 248.8 0.0 6.2e-74 248.3 0.0 1.3 1 0 0 1 1 1 1 Temperature dependent protein affecting M2 dsRNA replication MKT1_N PF12247.8 EXF78371.1 - 3e-31 107.6 0.0 6e-31 106.6 0.0 1.5 1 0 0 1 1 1 1 Temperature dependent protein affecting M2 dsRNA replication XPG_N PF00752.17 EXF78371.1 - 0.00046 20.6 0.0 0.0017 18.8 0.0 2.0 1 0 0 1 1 1 1 XPG N-terminal domain DNMT1-RFD PF12047.8 EXF78372.1 - 0.00018 21.6 0.0 0.00037 20.5 0.0 1.5 1 0 0 1 1 1 1 Cytosine specific DNA methyltransferase replication foci domain TruB_N PF01509.18 EXF78373.1 - 1.2e-44 152.2 0.0 3.8e-44 150.6 0.0 1.8 1 0 0 1 1 1 1 TruB family pseudouridylate synthase (N terminal domain) TruB_C_2 PF16198.5 EXF78373.1 - 0.00011 22.3 0.0 0.00022 21.3 0.0 1.5 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain Sec2p PF06428.11 EXF78374.1 - 9.2e-12 44.8 6.1 9.2e-12 44.8 6.1 1.8 2 0 0 2 2 2 1 GDP/GTP exchange factor Sec2p SlyX PF04102.12 EXF78374.1 - 0.014 16.0 11.1 0.56 10.9 3.1 3.2 2 1 1 3 3 3 0 SlyX TF_Zn_Ribbon PF08271.12 EXF78374.1 - 0.11 12.0 0.0 0.21 11.2 0.0 1.3 1 0 0 1 1 1 0 TFIIB zinc-binding MbeD_MobD PF04899.12 EXF78374.1 - 0.17 12.0 7.5 0.77 9.9 0.6 3.2 2 1 1 3 3 3 0 MbeD/MobD like BST2 PF16716.5 EXF78374.1 - 0.53 10.9 8.8 2 9.0 5.1 2.6 3 0 0 3 3 3 0 Bone marrow stromal antigen 2 HAUS-augmin3 PF14932.6 EXF78374.1 - 0.71 9.4 10.9 0.24 11.0 7.1 2.0 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 3 Lzipper-MIP1 PF14389.6 EXF78374.1 - 0.96 9.8 8.1 23 5.4 5.3 3.2 2 1 1 3 3 3 0 Leucine-zipper of ternary complex factor MIP1 Exonuc_VII_L PF02601.15 EXF78374.1 - 1.8 8.0 8.5 4.5 6.7 8.7 1.6 1 1 0 1 1 1 0 Exonuclease VII, large subunit Jnk-SapK_ap_N PF09744.9 EXF78374.1 - 2.2 8.5 12.8 7 6.8 8.9 2.2 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 DUF5446 PF17522.2 EXF78374.1 - 3.3 7.9 7.2 10 6.3 0.2 2.9 1 1 2 3 3 3 0 Family of unknown function (DUF5446) Atg14 PF10186.9 EXF78374.1 - 3.9 6.5 7.7 24 3.9 0.0 2.1 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4407 PF14362.6 EXF78374.1 - 4 6.7 8.7 32 3.7 8.7 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) FliT PF05400.13 EXF78374.1 - 4.1 8.3 18.5 1.1 10.1 0.1 3.3 3 1 0 3 3 3 0 Flagellar protein FliT EXOSC1 PF10447.9 EXF78375.1 - 1.8e-19 70.4 2.1 4.9e-14 52.9 0.2 2.5 1 1 1 2 2 2 2 Exosome component EXOSC1/CSL4 ECR1_N PF14382.6 EXF78375.1 - 2.3e-10 40.1 1.3 2.3e-10 40.1 1.3 1.7 2 0 0 2 2 2 1 Exosome complex exonuclease RRP4 N-terminal region MotA_activ PF09114.10 EXF78375.1 - 0.099 12.8 0.0 0.19 11.9 0.0 1.4 1 0 0 1 1 1 0 Transcription factor MotA, activation domain ERG2_Sigma1R PF04622.12 EXF78376.1 - 2.5e-97 324.3 0.3 2.9e-97 324.1 0.3 1.0 1 0 0 1 1 1 1 ERG2 and Sigma1 receptor like protein UCR_6-4kD PF08997.10 EXF78376.1 - 0.17 11.8 0.4 2.3 8.2 0.0 2.8 3 0 0 3 3 3 0 Ubiquinol-cytochrome C reductase complex, 6.4kD protein PTR2 PF00854.21 EXF78377.1 - 3.6e-77 259.8 4.7 4.8e-77 259.4 4.7 1.2 1 0 0 1 1 1 1 POT family Holin_SPP1 PF04688.13 EXF78377.1 - 0.087 13.0 0.3 0.32 11.2 0.3 1.9 1 0 0 1 1 1 0 SPP1 phage holin Sugar_tr PF00083.24 EXF78377.1 - 0.29 10.0 18.6 0.13 11.1 0.5 3.3 3 0 0 3 3 3 0 Sugar (and other) transporter Zn_clus PF00172.18 EXF78379.1 - 1.1e-06 28.7 9.3 1.8e-06 28.0 9.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EXF78379.1 - 0.0055 15.6 0.4 0.0084 15.0 0.4 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Glyco_hydro_3_C PF01915.22 EXF78380.1 - 1.3e-45 155.9 0.0 1.8e-45 155.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 EXF78380.1 - 8.1e-33 114.1 0.0 1.4e-32 113.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 EXF78380.1 - 1.6e-22 79.4 0.0 2.9e-22 78.6 0.0 1.4 1 0 0 1 1 1 1 Fibronectin type III-like domain FAD_binding_4 PF01565.23 EXF78381.1 - 2e-24 85.9 1.6 4.6e-24 84.7 1.6 1.7 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EXF78381.1 - 6.5e-09 35.8 1.4 1.2e-08 34.9 0.8 1.8 2 0 0 2 2 2 1 Berberine and berberine like DUF1772 PF08592.11 EXF78382.1 - 7.8e-34 116.9 0.3 9.4e-34 116.7 0.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1772) DUF5366 PF17328.2 EXF78382.1 - 0.057 13.5 0.1 0.096 12.8 0.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5366) AA_permease PF00324.21 EXF78383.1 - 1.1e-130 436.4 51.9 1.4e-130 436.1 51.9 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EXF78383.1 - 1.6e-32 112.9 57.5 1.9e-32 112.7 57.5 1.1 1 0 0 1 1 1 1 Amino acid permease NCE101 PF11654.8 EXF78383.1 - 0.26 11.0 0.9 0.72 9.6 0.1 2.1 2 0 0 2 2 2 0 Non-classical export protein 1 Amidohydro_2 PF04909.14 EXF78384.1 - 1.6e-46 159.4 0.7 1.9e-46 159.1 0.7 1.0 1 0 0 1 1 1 1 Amidohydrolase DUF1932 PF09130.11 EXF78385.1 - 6.3e-22 77.3 0.1 1.4e-21 76.2 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1932) NAD_binding_2 PF03446.15 EXF78385.1 - 0.00055 20.1 0.0 0.0009 19.4 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 EXF78385.1 - 0.0012 19.4 0.1 0.0023 18.5 0.1 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent 3HCDH_N PF02737.18 EXF78385.1 - 0.03 14.2 0.1 0.063 13.2 0.1 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain PDH PF02153.17 EXF78385.1 - 0.092 11.7 0.0 0.17 10.9 0.0 1.4 1 0 0 1 1 1 0 Prephenate dehydrogenase HET PF06985.11 EXF78386.1 - 3.5e-26 92.3 0.0 5.9e-26 91.6 0.0 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) FixH PF05751.11 EXF78388.1 - 0.15 12.0 0.7 0.8 9.7 0.0 2.1 2 0 0 2 2 2 0 FixH EamA PF00892.20 EXF78388.1 - 0.2 11.9 3.6 0.73 10.0 0.0 2.6 3 0 0 3 3 3 0 EamA-like transporter family Methyltransf_23 PF13489.6 EXF78389.1 - 1.6e-18 67.1 0.0 2.8e-18 66.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF78389.1 - 4.8e-12 46.4 0.0 1.3e-11 45.1 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF78389.1 - 3.2e-09 37.4 0.0 2.7e-08 34.4 0.0 2.4 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF78389.1 - 3.9e-09 37.0 0.0 9.6e-09 35.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF78389.1 - 4e-09 36.4 0.0 1.2e-08 34.9 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EXF78389.1 - 0.0012 18.4 0.0 0.0092 15.5 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_4 PF02390.17 EXF78389.1 - 0.0013 18.2 0.0 0.003 17.0 0.0 1.5 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_16 PF10294.9 EXF78389.1 - 0.014 15.1 0.0 0.026 14.3 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase CMAS PF02353.20 EXF78389.1 - 0.015 14.6 0.0 0.025 13.9 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase FtsJ PF01728.19 EXF78389.1 - 0.022 14.9 0.0 0.034 14.2 0.0 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase GidB PF02527.15 EXF78389.1 - 0.039 13.3 0.0 0.35 10.2 0.0 2.3 2 1 0 2 2 2 0 rRNA small subunit methyltransferase G PrmA PF06325.13 EXF78389.1 - 0.04 13.3 0.0 0.065 12.6 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_2 PF00891.18 EXF78389.1 - 0.05 12.9 0.0 0.3 10.4 0.0 2.0 2 0 0 2 2 2 0 O-methyltransferase domain PCMT PF01135.19 EXF78389.1 - 0.15 11.7 0.0 0.78 9.5 0.0 1.9 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Glyco_hydro_75 PF07335.11 EXF78390.1 - 8.2e-67 224.5 0.4 1e-66 224.3 0.4 1.1 1 0 0 1 1 1 1 Fungal chitosanase of glycosyl hydrolase group 75 p450 PF00067.22 EXF78391.1 - 6.8e-64 216.3 0.0 1.1e-63 215.6 0.0 1.2 1 1 0 1 1 1 1 Cytochrome P450 Abhydrolase_1 PF00561.20 EXF78392.1 - 1.2e-24 87.4 0.0 5e-24 85.3 0.0 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EXF78392.1 - 4.8e-16 58.7 0.0 5.9e-16 58.5 0.0 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EXF78392.1 - 6.4e-13 49.8 0.1 8.3e-13 49.4 0.1 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_4 PF08386.10 EXF78392.1 - 1.4e-05 25.1 0.0 3.1e-05 24.0 0.0 1.5 1 0 0 1 1 1 1 TAP-like protein Ndr PF03096.14 EXF78392.1 - 0.025 13.3 0.0 0.054 12.2 0.0 1.5 1 0 0 1 1 1 0 Ndr family Esterase PF00756.20 EXF78392.1 - 0.037 13.7 0.1 0.051 13.2 0.1 1.4 1 1 0 1 1 1 0 Putative esterase Acyl_transf_2 PF02273.15 EXF78392.1 - 0.054 12.7 0.0 0.1 11.8 0.0 1.4 1 0 0 1 1 1 0 Acyl transferase PGAP1 PF07819.13 EXF78392.1 - 0.058 13.1 0.0 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 PGAP1-like protein Peptidase_S28 PF05577.12 EXF78392.1 - 0.084 11.6 0.0 0.11 11.2 0.0 1.2 1 0 0 1 1 1 0 Serine carboxypeptidase S28 NAD_binding_2 PF03446.15 EXF78393.1 - 6.4e-31 107.7 0.0 1.1e-30 106.9 0.0 1.4 1 1 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 EXF78393.1 - 2.4e-19 69.8 0.0 3.8e-19 69.1 0.0 1.3 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase GFO_IDH_MocA PF01408.22 EXF78393.1 - 0.00034 21.4 0.2 0.00065 20.5 0.2 1.6 1 1 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold OCD_Mu_crystall PF02423.15 EXF78393.1 - 0.00067 18.7 0.0 0.0012 17.9 0.0 1.3 1 0 0 1 1 1 1 Ornithine cyclodeaminase/mu-crystallin family Sacchrp_dh_NADP PF03435.18 EXF78393.1 - 0.0014 18.9 0.1 0.0035 17.6 0.0 1.7 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain F420_oxidored PF03807.17 EXF78393.1 - 0.011 16.3 0.2 0.041 14.5 0.1 2.0 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent NusG_add PF18298.1 EXF78393.1 - 0.13 12.5 0.0 0.24 11.6 0.0 1.4 1 0 0 1 1 1 0 NusG additional domain NAD_binding_10 PF13460.6 EXF78394.1 - 0.0011 18.9 0.0 0.087 12.7 0.0 2.2 2 0 0 2 2 2 2 NAD(P)H-binding adh_short PF00106.25 EXF78395.1 - 9.8e-39 132.8 0.0 1.3e-38 132.4 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF78395.1 - 9.8e-30 103.8 0.0 1.2e-29 103.5 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF78395.1 - 6.5e-10 39.2 0.0 1.3e-09 38.2 0.0 1.5 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 EXF78395.1 - 1.8e-07 30.9 0.2 3.5e-06 26.7 0.2 2.2 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family AlaDh_PNT_C PF01262.21 EXF78395.1 - 0.0012 18.2 0.1 0.0019 17.6 0.1 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Polysacc_synt_2 PF02719.15 EXF78395.1 - 0.012 14.8 0.0 0.016 14.3 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.19 EXF78395.1 - 0.019 14.0 0.0 0.039 12.9 0.0 1.6 2 0 0 2 2 2 0 3-beta hydroxysteroid dehydrogenase/isomerase family ADH_zinc_N PF00107.26 EXF78395.1 - 0.057 13.4 0.0 0.12 12.3 0.0 1.6 1 0 0 1 1 1 0 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 EXF78395.1 - 0.18 11.1 0.0 0.3 10.4 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Methyltransf_34 PF11312.8 EXF78395.1 - 0.21 10.8 0.0 3.3 6.9 0.0 2.0 2 0 0 2 2 2 0 Putative SAM-dependent methyltransferase p450 PF00067.22 EXF78396.1 - 2.1e-66 224.6 0.0 2.4e-66 224.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 NAD_binding_2 PF03446.15 EXF78397.1 - 5.6e-37 127.3 0.0 1.2e-36 126.3 0.0 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 EXF78397.1 - 1.1e-22 80.6 0.0 1.9e-22 79.8 0.0 1.5 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase CMD PF02627.20 EXF78397.1 - 5.9e-20 71.1 0.3 1.5e-19 69.9 0.3 1.7 1 0 0 1 1 1 1 Carboxymuconolactone decarboxylase family OCD_Mu_crystall PF02423.15 EXF78397.1 - 2.3e-05 23.5 0.0 3.5e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 Ornithine cyclodeaminase/mu-crystallin family F420_oxidored PF03807.17 EXF78397.1 - 0.00053 20.5 0.0 0.0018 18.8 0.0 1.9 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Lactamase_B PF00753.27 EXF78397.1 - 0.00062 19.8 2.0 0.0014 18.6 2.0 1.7 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EXF78397.1 - 0.0033 16.9 0.0 0.011 15.2 0.0 1.9 2 0 0 2 2 2 1 Beta-lactamase superfamily domain GFO_IDH_MocA PF01408.22 EXF78397.1 - 0.11 13.4 0.0 0.23 12.3 0.0 1.5 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold Fungal_trans PF04082.18 EXF78398.1 - 7.8e-10 38.2 0.4 1.4e-09 37.4 0.4 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 EXF78398.1 - 8.4e-06 26.0 19.1 0.0019 18.5 3.3 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type Lactamase_B PF00753.27 EXF78398.1 - 7.9e-05 22.7 0.0 0.00018 21.6 0.0 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EXF78398.1 - 0.002 17.7 0.0 0.0052 16.3 0.0 1.8 1 0 0 1 1 1 1 Beta-lactamase superfamily domain zf-C2H2_4 PF13894.6 EXF78398.1 - 0.0054 17.5 17.0 0.23 12.4 2.5 3.0 2 0 0 2 2 2 2 C2H2-type zinc finger Lactamase_B_3 PF13483.6 EXF78398.1 - 0.022 14.7 0.0 0.045 13.6 0.0 1.5 1 0 0 1 1 1 0 Beta-lactamase superfamily domain zf-H2C2_2 PF13465.6 EXF78398.1 - 0.13 12.8 24.2 0.034 14.6 10.5 2.9 3 0 0 3 3 3 0 Zinc-finger double domain zf-BED PF02892.15 EXF78398.1 - 1.2 9.2 10.5 2 8.5 3.6 2.7 1 1 1 2 2 2 0 BED zinc finger FAD_binding_4 PF01565.23 EXF78399.1 - 1.2e-19 70.4 0.1 1.8e-19 69.9 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain Lectin_leg-like PF03388.13 EXF78400.1 - 6.8e-25 87.8 0.0 1.2e-24 87.0 0.0 1.3 1 0 0 1 1 1 1 Legume-like lectin family DUF5523 PF17661.1 EXF78400.1 - 0.00029 20.6 2.1 0.00044 20.0 2.1 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5523) Spt20 PF12090.8 EXF78400.1 - 0.0027 17.3 18.1 0.0043 16.7 18.1 1.2 1 0 0 1 1 1 1 Spt20 family Tmemb_cc2 PF10267.9 EXF78400.1 - 0.0093 15.2 11.1 0.013 14.7 11.1 1.1 1 0 0 1 1 1 1 Predicted transmembrane and coiled-coil 2 protein TFIIA PF03153.13 EXF78400.1 - 0.014 15.4 15.7 0.021 14.9 15.7 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit MCU PF04678.13 EXF78400.1 - 0.024 14.7 3.5 0.95 9.5 0.1 2.2 2 0 0 2 2 2 0 Mitochondrial calcium uniporter DUF2722 PF10846.8 EXF78400.1 - 0.027 13.4 13.5 0.041 12.8 13.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) SesA PF17107.5 EXF78400.1 - 0.034 14.3 0.3 0.072 13.3 0.3 1.4 1 0 0 1 1 1 0 N-terminal domain on NACHT_NTPase and P-loop NTPases PDGLE PF13190.6 EXF78400.1 - 0.038 13.9 1.7 0.25 11.3 0.0 2.7 2 0 0 2 2 2 0 PDGLE domain CCDC53 PF10152.9 EXF78400.1 - 0.039 14.4 7.6 1.1 9.6 3.3 2.3 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex CPSF100_C PF13299.6 EXF78400.1 - 0.058 13.6 2.1 0.099 12.8 2.1 1.4 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF4175 PF13779.6 EXF78400.1 - 0.17 9.8 17.5 0.21 9.4 17.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) FAM76 PF16046.5 EXF78400.1 - 0.53 9.6 12.0 0.99 8.7 12.0 1.3 1 0 0 1 1 1 0 FAM76 protein PepSY_TM PF03929.16 EXF78400.1 - 0.88 9.2 2.7 1.6 8.4 2.7 1.3 1 0 0 1 1 1 0 PepSY-associated TM region Presenilin PF01080.17 EXF78400.1 - 1.4 7.6 7.3 2 7.1 7.3 1.2 1 0 0 1 1 1 0 Presenilin Roughex PF06020.11 EXF78400.1 - 9.1 5.3 9.2 13 4.8 9.2 1.1 1 0 0 1 1 1 0 Drosophila roughex protein Alg6_Alg8 PF03155.15 EXF78401.1 - 4.9e-179 596.3 25.4 5.7e-179 596.1 25.4 1.0 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family MerC PF03203.14 EXF78401.1 - 0.014 15.9 7.7 0.014 15.9 7.7 3.3 2 2 0 2 2 2 0 MerC mercury resistance protein VIT1 PF01988.19 EXF78401.1 - 4.6 7.1 7.6 0.71 9.7 0.9 2.4 2 0 0 2 2 2 0 VIT family WAC_Acf1_DNA_bd PF10537.9 EXF78403.1 - 3.1e-39 133.6 1.2 1.9e-38 131.0 0.0 2.8 2 0 0 2 2 2 1 ATP-utilising chromatin assembly and remodelling N-terminal WSD PF15613.6 EXF78403.1 - 8.1e-19 67.9 0.1 8.1e-19 67.9 0.1 4.1 5 1 0 5 5 5 1 Williams-Beuren syndrome DDT (WSD), D-TOX E motif DDT PF02791.17 EXF78403.1 - 8.5e-17 61.2 0.3 1.6e-16 60.4 0.3 1.5 1 0 0 1 1 1 1 DDT domain WHIM1 PF15612.6 EXF78403.1 - 3.5e-07 29.6 0.1 8e-06 25.3 0.0 2.6 2 0 0 2 2 2 1 WSTF, HB1, Itc1p, MBD9 motif 1 Nop53 PF07767.11 EXF78403.1 - 10 5.4 51.2 0.28 10.5 18.2 3.4 3 0 0 3 3 3 0 Nop53 (60S ribosomal biogenesis) RNase_H PF00075.24 EXF78404.1 - 6.2e-10 39.4 0.0 1.3e-09 38.4 0.0 1.6 1 0 0 1 1 1 1 RNase H RVT_3 PF13456.6 EXF78404.1 - 0.038 13.8 0.0 0.075 12.8 0.0 1.5 1 0 0 1 1 1 0 Reverse transcriptase-like YL1 PF05764.13 EXF78404.1 - 0.17 12.0 9.5 0.33 11.0 9.5 1.5 1 0 0 1 1 1 0 YL1 nuclear protein CDC45 PF02724.14 EXF78404.1 - 5.8 5.1 9.7 8.6 4.5 9.7 1.2 1 0 0 1 1 1 0 CDC45-like protein Zn_clus PF00172.18 EXF78405.1 - 6.1e-09 35.9 13.3 1.1e-08 35.0 13.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EXF78405.1 - 3.8e-05 22.7 0.0 5.8e-05 22.1 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Metallophos PF00149.28 EXF78407.1 - 1.5e-16 61.5 1.9 1.9e-16 61.2 1.9 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EXF78407.1 - 8.5e-05 22.8 0.0 0.0002 21.6 0.0 1.5 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase superfamily domain DUF4159 PF13709.6 EXF78407.1 - 0.013 14.9 0.0 0.032 13.7 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4159) SSURE PF11966.8 EXF78407.1 - 0.16 11.7 0.0 0.31 10.8 0.0 1.4 1 0 0 1 1 1 0 Fibronectin-binding repeat Amidohydro_3 PF07969.11 EXF78408.1 - 5.3e-14 52.5 0.5 1.2e-06 28.3 0.0 2.9 2 0 0 2 2 2 2 Amidohydrolase family Amidohydro_1 PF01979.20 EXF78408.1 - 5.7e-11 42.3 0.0 4e-07 29.7 0.0 3.1 3 0 0 3 3 3 2 Amidohydrolase family MciZ PF13072.6 EXF78408.1 - 0.22 11.4 0.0 16 5.4 0.0 2.7 3 0 0 3 3 3 0 Mother cell inhibitor of FtsZ DUF1996 PF09362.10 EXF78409.1 - 1.9e-61 208.0 0.9 2.6e-61 207.6 0.9 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1996) Serglycin PF04360.12 EXF78409.1 - 0.63 10.0 5.3 1.3 8.9 5.3 1.5 1 0 0 1 1 1 0 Serglycin Methyltr_RsmB-F PF01189.17 EXF78410.1 - 2e-17 63.5 0.0 4.7e-11 42.7 0.0 2.4 2 0 0 2 2 2 2 16S rRNA methyltransferase RsmB/F DUF5024 PF16427.5 EXF78410.1 - 0.032 14.6 0.0 0.092 13.1 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF5024) DUF1856 PF08983.10 EXF78411.1 - 0.12 12.6 0.9 0.35 11.1 0.9 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF1856) Thioredoxin_6 PF13848.6 EXF78412.1 - 1.1e-19 71.1 0.0 3e-09 37.0 0.0 2.1 1 1 1 2 2 2 2 Thioredoxin-like domain Thioredoxin PF00085.20 EXF78412.1 - 0.0064 16.5 0.0 0.036 14.1 0.0 2.2 3 0 0 3 3 3 1 Thioredoxin MFS_1 PF07690.16 EXF78413.1 - 1e-37 129.9 46.8 1e-37 129.9 46.8 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF78413.1 - 0.00043 19.3 23.7 0.00043 19.3 23.7 2.5 1 1 1 2 2 2 1 Sugar (and other) transporter BTB PF00651.31 EXF78414.1 - 2.5e-06 27.7 0.0 4.4e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain CREPT PF16566.5 EXF78415.1 - 0.55 10.4 6.2 0.97 9.6 6.2 1.4 1 0 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour DUF5082 PF16888.5 EXF78416.1 - 0.12 12.6 0.1 0.19 12.0 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5082) GrpB PF04229.14 EXF78416.1 - 0.15 12.3 0.0 0.22 11.7 0.0 1.2 1 0 0 1 1 1 0 GrpB protein DUF5364 PF17322.2 EXF78417.1 - 0.0066 16.8 4.1 0.0087 16.4 4.1 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5364) SH3BGR PF04908.15 EXF78417.1 - 0.18 12.0 1.0 0.34 11.1 0.5 1.7 1 1 1 2 2 2 0 SH3-binding, glutamic acid-rich protein MFS_1 PF07690.16 EXF78419.1 - 2e-45 155.3 59.5 6.7e-40 137.1 34.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF78419.1 - 4.5e-14 52.2 10.4 4.5e-14 52.2 10.4 3.0 3 0 0 3 3 3 2 Sugar (and other) transporter TRI12 PF06609.13 EXF78419.1 - 4e-06 25.5 3.6 7.4e-06 24.7 3.6 1.4 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) OATP PF03137.20 EXF78419.1 - 3.4e-05 22.4 4.6 3.4e-05 22.4 4.6 2.7 2 1 0 3 3 3 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1_like PF12832.7 EXF78419.1 - 0.06 12.2 0.1 0.06 12.2 0.1 2.8 3 0 0 3 3 3 0 MFS_1 like family TcpE PF12648.7 EXF78419.1 - 0.23 12.0 4.3 0.15 12.6 0.9 2.5 2 0 0 2 2 2 0 TcpE family HTH_12 PF08461.10 EXF78420.1 - 0.28 11.1 2.0 0.82 9.7 2.0 1.8 1 1 0 1 1 1 0 Ribonuclease R winged-helix domain Chitin_synth_2 PF03142.15 EXF78422.1 - 5.2e-25 88.1 7.8 2.1e-24 86.1 2.6 2.9 3 0 0 3 3 3 2 Chitin synthase Glyco_trans_2_3 PF13632.6 EXF78422.1 - 3.6e-16 59.7 4.4 3.6e-16 59.7 4.4 2.4 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 EXF78422.1 - 1.6e-12 47.8 0.0 3.4e-12 46.8 0.0 1.6 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 EXF78422.1 - 0.0026 17.6 0.2 0.4 10.5 0.0 2.5 2 0 0 2 2 2 2 Glycosyl transferase family 2 HSP70 PF00012.20 EXF78423.1 - 9.8e-163 542.5 7.5 9.8e-163 542.5 7.5 2.5 1 1 1 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.13 EXF78423.1 - 9.2e-14 51.0 0.2 8.6e-13 47.8 0.0 2.2 2 0 0 2 2 2 1 MreB/Mbl protein FtsA PF14450.6 EXF78423.1 - 0.0036 17.7 6.3 0.073 13.5 0.1 3.1 3 1 0 3 3 3 2 Cell division protein FtsA GTP_EFTU PF00009.27 EXF78424.1 - 2.8e-34 118.4 1.3 5.8e-34 117.3 0.0 2.3 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 EXF78424.1 - 1.1e-19 70.5 0.0 3e-19 69.1 0.0 1.8 1 0 0 1 1 1 1 Translation-initiation factor 2 GTP_EFTU_D4 PF14578.6 EXF78424.1 - 5.6e-08 32.6 1.3 3.8e-07 29.9 1.3 2.5 1 1 0 1 1 1 1 Elongation factor Tu domain 4 GTP_EFTU_D2 PF03144.25 EXF78424.1 - 1.4e-07 31.8 9.6 3e-07 30.7 0.1 3.3 3 0 0 3 3 3 2 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EXF78424.1 - 5.6e-07 29.6 0.1 1.3e-05 25.3 0.0 3.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase Roc PF08477.13 EXF78424.1 - 0.00094 19.4 0.0 0.0027 17.9 0.0 1.8 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase ATP_bind_1 PF03029.17 EXF78424.1 - 0.023 14.5 0.0 0.023 14.5 0.0 2.4 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein AAA_22 PF13401.6 EXF78424.1 - 0.39 11.0 1.7 2.3 8.5 0.1 2.9 2 1 0 2 2 2 0 AAA domain MMS1_N PF10433.9 EXF78425.1 - 5.4e-61 206.7 0.0 2.5e-60 204.5 0.0 2.0 3 0 0 3 3 3 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term RabGAP-TBC PF00566.18 EXF78426.1 - 1.5e-19 70.6 0.1 3e-19 69.6 0.0 1.5 2 0 0 2 2 2 1 Rab-GTPase-TBC domain Vps52 PF04129.12 EXF78427.1 - 5.1e-126 421.4 0.0 6.7e-126 421.0 0.0 1.0 1 0 0 1 1 1 1 Vps52 / Sac2 family Sec3_C PF09763.9 EXF78427.1 - 3.7e-06 25.7 2.0 2.5e-05 22.9 2.1 1.9 1 1 0 1 1 1 1 Exocyst complex component Sec3 Exo70 PF03081.15 EXF78427.1 - 0.0066 15.5 0.1 0.017 14.2 0.0 1.7 2 0 0 2 2 2 1 Exo70 exocyst complex subunit Filament PF00038.21 EXF78427.1 - 0.13 11.8 4.0 0.42 10.1 0.1 2.6 3 0 0 3 3 3 0 Intermediate filament protein eIF-5a PF01287.20 EXF78428.1 - 2.3e-27 94.9 1.6 3.3e-27 94.4 1.6 1.2 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold EFP_N PF08207.12 EXF78428.1 - 0.0038 17.2 0.1 0.02 14.9 0.0 2.1 2 0 0 2 2 2 1 Elongation factor P (EF-P) KOW-like domain zf-RRN7 PF11781.8 EXF78429.1 - 1.7e-05 24.4 0.6 2.9e-05 23.6 0.6 1.4 1 0 0 1 1 1 1 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Yip1 PF04893.17 EXF78430.1 - 2.2e-11 43.8 16.9 2.2e-11 43.8 16.9 1.4 1 1 0 1 1 1 1 Yip1 domain Rhodanese PF00581.20 EXF78431.1 - 7.3e-13 49.0 0.0 1.3e-12 48.2 0.0 1.4 1 0 0 1 1 1 1 Rhodanese-like domain HAD PF12710.7 EXF78434.1 - 4.1e-24 86.0 0.1 5.5e-24 85.6 0.1 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.12 EXF78434.1 - 0.0018 17.7 0.0 0.0084 15.5 0.0 1.8 1 1 0 1 1 1 1 Putative Phosphatase Hydrolase PF00702.26 EXF78434.1 - 0.057 13.7 1.0 0.096 13.0 0.1 1.9 2 1 0 2 2 2 0 haloacid dehalogenase-like hydrolase UMPH-1 PF05822.12 EXF78434.1 - 0.063 12.8 0.0 0.15 11.5 0.0 1.7 2 0 0 2 2 2 0 Pyrimidine 5'-nucleotidase (UMPH-1) Coatomer_E PF04733.14 EXF78435.1 - 3.4e-62 210.5 7.0 3.9e-62 210.3 7.0 1.0 1 0 0 1 1 1 1 Coatomer epsilon subunit ANAPC3 PF12895.7 EXF78435.1 - 1.5e-07 31.5 0.4 0.24 11.6 0.0 3.4 3 0 0 3 3 3 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 EXF78435.1 - 3.8e-07 30.5 24.4 0.0057 17.1 5.5 4.2 3 1 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 EXF78435.1 - 5.5e-05 23.4 16.0 0.15 12.3 2.3 5.0 4 2 1 5 5 5 4 Tetratricopeptide repeat TPR_14 PF13428.6 EXF78435.1 - 0.00097 19.8 18.6 0.16 12.8 3.1 5.7 4 3 1 5 5 5 1 Tetratricopeptide repeat TPR_1 PF00515.28 EXF78435.1 - 0.0067 16.2 5.3 2.4 8.1 0.1 4.5 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_8 PF13181.6 EXF78435.1 - 0.0069 16.5 3.4 5.5 7.5 0.0 4.5 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_4 PF07721.14 EXF78435.1 - 0.021 15.4 2.9 0.1 13.3 1.3 5.5 8 0 0 8 8 6 0 Tetratricopeptide repeat Type_III_YscG PF09477.10 EXF78435.1 - 0.21 11.7 4.2 2 8.5 0.1 3.3 1 1 3 4 4 4 0 Bacterial type II secretion system chaperone protein (type_III_yscG) TPR_7 PF13176.6 EXF78435.1 - 0.21 11.7 9.5 28 5.0 0.0 5.2 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_6 PF13174.6 EXF78435.1 - 0.24 12.1 7.7 9 7.2 0.2 4.7 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 EXF78435.1 - 0.44 10.8 16.7 0.18 12.0 0.8 5.7 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_9 PF13371.6 EXF78435.1 - 1.1 9.4 6.1 2.6 8.2 0.8 3.3 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 EXF78435.1 - 1.5 9.5 17.9 3.2 8.5 2.6 4.4 3 2 2 5 5 5 0 Tetratricopeptide repeat TPR_11 PF13414.6 EXF78435.1 - 9.4 6.0 9.6 2.2 8.1 1.3 3.9 4 0 0 4 4 4 0 TPR repeat SAM_2 PF07647.17 EXF78437.1 - 3.6e-14 52.6 0.0 7.6e-14 51.6 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SH3_9 PF14604.6 EXF78437.1 - 5.1e-12 45.5 0.0 1.3e-11 44.1 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EXF78437.1 - 2.1e-10 40.0 0.0 4.1e-10 39.1 0.0 1.5 1 0 0 1 1 1 1 SH3 domain PH PF00169.29 EXF78437.1 - 7.1e-10 39.3 0.0 2.2e-09 37.8 0.0 1.8 1 0 0 1 1 1 1 PH domain SH3_2 PF07653.17 EXF78437.1 - 0.00028 20.5 0.0 0.00063 19.4 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain PH_11 PF15413.6 EXF78437.1 - 0.002 18.5 0.0 0.0053 17.2 0.0 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.6 EXF78437.1 - 0.03 14.6 0.0 0.19 12.0 0.0 2.2 2 0 0 2 2 2 0 Pleckstrin homology domain SAM_1 PF00536.30 EXF78437.1 - 0.08 13.4 0.0 0.15 12.5 0.0 1.4 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) zf-MIZ PF02891.20 EXF78438.1 - 2.7e-08 33.4 3.9 1.5e-06 27.8 0.3 2.5 2 0 0 2 2 2 2 MIZ/SP-RING zinc finger Arrestin_N PF00339.29 EXF78439.1 - 1.6e-15 57.5 0.0 8.9e-11 42.0 0.0 3.0 3 0 0 3 3 3 2 Arrestin (or S-antigen), N-terminal domain PGAP1 PF07819.13 EXF78440.1 - 1.9e-06 27.8 0.0 3.4e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein Palm_thioest PF02089.15 EXF78440.1 - 3.9e-06 26.9 0.0 8e-05 22.6 0.0 2.3 2 0 0 2 2 2 1 Palmitoyl protein thioesterase DUF676 PF05057.14 EXF78440.1 - 7.1e-06 25.7 0.0 1.4e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_6 PF12697.7 EXF78440.1 - 0.00021 22.0 0.6 0.00027 21.6 0.6 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family LCAT PF02450.15 EXF78440.1 - 0.0011 18.3 0.0 0.0017 17.6 0.0 1.2 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase Abhydro_lipase PF04083.16 EXF78440.1 - 0.0037 16.8 0.0 0.0063 16.1 0.0 1.3 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region DUF915 PF06028.11 EXF78440.1 - 0.025 13.9 0.1 0.097 12.0 0.0 1.9 3 0 0 3 3 3 0 Alpha/beta hydrolase of unknown function (DUF915) Ser_hydrolase PF06821.13 EXF78440.1 - 0.031 14.1 0.0 0.071 13.0 0.0 1.6 2 0 0 2 2 2 0 Serine hydrolase Abhydrolase_1 PF00561.20 EXF78440.1 - 0.043 13.4 0.3 0.12 12.0 0.3 1.8 1 1 0 1 1 1 0 alpha/beta hydrolase fold Lipase_2 PF01674.18 EXF78440.1 - 0.052 13.1 0.1 0.18 11.3 0.1 1.8 2 0 0 2 2 2 0 Lipase (class 2) DUF900 PF05990.12 EXF78440.1 - 0.13 11.7 0.0 0.22 11.0 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) RTA1 PF04479.13 EXF78442.1 - 2.9e-28 98.9 6.8 3.7e-28 98.6 6.8 1.1 1 0 0 1 1 1 1 RTA1 like protein Rhomboid PF01694.22 EXF78443.1 - 1.4e-17 64.1 5.1 2.3e-17 63.4 5.1 1.3 1 0 0 1 1 1 1 Rhomboid family TPR_1 PF00515.28 EXF78446.1 - 0.0068 16.2 1.4 0.039 13.8 0.0 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_21 PF09976.9 EXF78446.1 - 0.019 14.7 0.3 0.022 14.5 0.3 1.2 1 0 0 1 1 1 0 Tetratricopeptide repeat-like domain TPR_12 PF13424.6 EXF78446.1 - 0.037 14.3 4.5 0.063 13.6 4.5 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_2 PF07719.17 EXF78446.1 - 0.46 10.7 4.8 0.61 10.3 0.2 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat FPP PF05911.11 EXF78447.1 - 0.00019 19.8 28.6 0.00044 18.6 28.6 1.5 1 0 0 1 1 1 1 Filament-like plant protein, long coiled-coil Peptidase_M15_2 PF05951.13 EXF78447.1 - 0.02 14.6 0.1 0.062 13.0 0.1 1.9 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF882) NAD_binding_6 PF08030.12 EXF78449.1 - 2.7e-22 79.6 0.0 3.7e-22 79.1 0.0 1.2 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.19 EXF78449.1 - 1.7e-12 47.6 13.2 1.7e-12 47.6 13.2 2.1 2 0 0 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 EXF78449.1 - 9.7e-08 32.1 0.0 2.2e-07 30.9 0.0 1.5 1 0 0 1 1 1 1 FAD-binding domain S19 PF06756.11 EXF78449.1 - 0.015 15.2 0.3 0.039 13.9 0.1 1.8 2 0 0 2 2 2 0 Chorion protein S19 C-terminal Methyltransf_25 PF13649.6 EXF78450.1 - 2.3e-05 25.0 0.0 3.6e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EXF78450.1 - 3.5e-05 23.7 0.0 3.8e-05 23.6 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain DREV PF05219.12 EXF78450.1 - 0.00012 21.3 0.0 0.00025 20.2 0.0 1.5 1 1 1 2 2 2 1 DREV methyltransferase Methyltransf_11 PF08241.12 EXF78450.1 - 0.00073 20.1 0.0 0.001 19.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain RrnaAD PF00398.20 EXF78450.1 - 0.0014 17.7 0.0 0.0017 17.5 0.0 1.0 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase MTS PF05175.14 EXF78450.1 - 0.0018 17.9 0.0 0.0021 17.7 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_12 PF08242.12 EXF78450.1 - 0.0065 17.2 0.0 0.0096 16.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 EXF78450.1 - 0.016 15.0 0.1 0.035 13.9 0.0 1.5 1 1 1 2 2 2 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) FtsJ PF01728.19 EXF78450.1 - 0.021 14.9 0.0 0.026 14.7 0.0 1.1 1 0 0 1 1 1 0 FtsJ-like methyltransferase Ubie_methyltran PF01209.18 EXF78450.1 - 0.096 12.0 0.0 0.11 11.8 0.0 1.1 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.6 EXF78450.1 - 0.096 12.5 0.0 0.14 11.9 0.0 1.4 1 1 0 1 1 1 0 Methyltransferase domain Cys_Met_Meta_PP PF01053.20 EXF78453.1 - 1.8e-56 191.3 0.0 4e-56 190.2 0.0 1.5 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 EXF78453.1 - 0.13 11.4 0.0 0.27 10.4 0.0 1.4 1 1 0 1 1 1 0 Aminotransferase class I and II Terpene_synth_C PF03936.16 EXF78454.1 - 2.4e-06 27.1 0.5 1e-05 25.0 0.6 1.8 1 1 1 2 2 2 1 Terpene synthase family, metal binding domain Polysacc_deac_1 PF01522.21 EXF78455.1 - 1.3e-19 70.3 0.0 3.1e-19 69.1 0.0 1.6 2 0 0 2 2 2 1 Polysaccharide deacetylase Polysacc_deac_2 PF04748.13 EXF78455.1 - 0.0086 15.3 0.0 0.015 14.5 0.0 1.5 1 0 0 1 1 1 1 Divergent polysaccharide deacetylase DUF2026 PF09641.10 EXF78457.1 - 0.032 13.9 0.1 0.084 12.5 0.0 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF2026) Skp1 PF01466.19 EXF78457.1 - 0.043 13.9 0.3 0.088 12.9 0.3 1.5 1 0 0 1 1 1 0 Skp1 family, dimerisation domain DUF5117 PF17148.4 EXF78457.1 - 0.87 9.4 4.5 0.27 11.1 1.4 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF5117) WD40 PF00400.32 EXF78458.1 - 2.5e-14 53.4 8.1 0.0095 16.8 0.1 5.6 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EXF78458.1 - 7.9e-07 29.3 0.6 0.0024 18.1 0.2 4.0 2 1 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EXF78458.1 - 1.2e-06 27.6 0.9 2e-05 23.4 0.1 2.6 2 1 1 3 3 3 1 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 EXF78458.1 - 0.026 13.3 0.0 6.3 5.4 0.0 2.8 2 1 1 3 3 3 0 Nup133 N terminal like HA2 PF04408.23 EXF78459.1 - 2.6e-22 79.2 0.0 2.6e-22 79.2 0.0 3.7 4 1 0 4 4 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EXF78459.1 - 2.1e-19 69.7 0.0 5.1e-19 68.4 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EXF78459.1 - 4e-11 43.2 0.0 9.6e-11 42.0 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EXF78459.1 - 1e-07 31.9 0.0 1.9e-07 31.0 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF2075 PF09848.9 EXF78459.1 - 0.00011 21.6 0.0 0.0002 20.7 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_22 PF13401.6 EXF78459.1 - 0.00012 22.4 0.1 0.00031 21.0 0.1 1.7 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 EXF78459.1 - 0.0014 17.7 0.0 0.0029 16.7 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein SRP54 PF00448.22 EXF78459.1 - 0.0033 17.1 0.1 0.0066 16.1 0.1 1.5 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain ResIII PF04851.15 EXF78459.1 - 0.0039 17.2 0.0 1.4 8.9 0.0 2.6 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 EXF78459.1 - 0.0046 16.7 0.0 0.01 15.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 EXF78459.1 - 0.0061 15.9 0.0 0.013 14.9 0.0 1.5 1 0 0 1 1 1 1 KaiC AAA_19 PF13245.6 EXF78459.1 - 0.0062 16.9 0.0 0.014 15.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain Flavi_DEAD PF07652.14 EXF78459.1 - 0.029 14.3 0.0 0.055 13.4 0.0 1.4 1 0 0 1 1 1 0 Flavivirus DEAD domain GAD PF02938.14 EXF78459.1 - 0.041 14.1 0.0 0.12 12.6 0.0 1.7 1 0 0 1 1 1 0 GAD domain TrwB_AAD_bind PF10412.9 EXF78459.1 - 0.093 11.6 0.0 0.16 10.8 0.0 1.3 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain ABC_tran PF00005.27 EXF78459.1 - 0.096 13.2 0.3 0.28 11.7 0.0 2.0 2 0 0 2 2 1 0 ABC transporter Myosin_head PF00063.21 EXF78459.1 - 0.1 10.8 0.0 0.16 10.1 0.0 1.2 1 0 0 1 1 1 0 Myosin head (motor domain) AAA_25 PF13481.6 EXF78459.1 - 0.11 12.1 0.0 0.26 10.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 EXF78459.1 - 0.16 12.0 0.1 0.88 9.6 0.1 2.1 1 1 0 1 1 1 0 AAA domain Acylphosphatase PF00708.18 EXF78460.1 - 5e-24 84.5 0.1 5.4e-24 84.4 0.1 1.0 1 0 0 1 1 1 1 Acylphosphatase Virulence_RhuM PF13310.6 EXF78460.1 - 0.11 11.7 0.0 0.12 11.6 0.0 1.1 1 0 0 1 1 1 0 Virulence protein RhuM family Hep_59 PF07052.11 EXF78461.1 - 9.3e-18 64.9 3.0 2.7e-17 63.5 0.0 2.8 3 0 0 3 3 3 1 Hepatocellular carcinoma-associated antigen 59 FAM193_C PF15914.5 EXF78461.1 - 0.33 10.7 2.2 0.25 11.1 0.5 1.7 2 0 0 2 2 2 0 FAM193 family C-terminal BTK PF00779.19 EXF78464.1 - 0.0058 16.4 0.6 0.0096 15.7 0.6 1.4 1 0 0 1 1 1 1 BTK motif Lactamase_B_3 PF13483.6 EXF78465.1 - 1.8e-06 27.9 0.0 8.3e-06 25.8 0.0 1.9 2 0 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B_2 PF12706.7 EXF78465.1 - 0.00037 20.1 0.0 0.00063 19.3 0.0 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain BPL_LplA_LipB PF03099.19 EXF78468.1 - 7.5e-06 25.9 0.0 1.6e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family Chorismate_synt PF01264.21 EXF78469.1 - 2.6e-135 450.4 0.0 2.9e-135 450.2 0.0 1.0 1 0 0 1 1 1 1 Chorismate synthase Peptidase_M24 PF00557.24 EXF78470.1 - 7.2e-06 25.8 0.0 1.4e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 Metallopeptidase family M24 Glyco_hydro_71 PF03659.14 EXF78471.1 - 3.4e-134 447.4 5.2 3.4e-134 447.4 5.2 1.9 2 0 0 2 2 2 1 Glycosyl hydrolase family 71 Tyrosinase PF00264.20 EXF78473.1 - 3.3e-47 161.6 4.9 7.5e-47 160.5 4.9 1.5 1 0 0 1 1 1 1 Common central domain of tyrosinase Tyosinase_C PF18132.1 EXF78473.1 - 6.9e-37 126.8 0.0 1.4e-36 125.8 0.0 1.5 1 0 0 1 1 1 1 Tyosinase C-terminal domain Fungal_trans_2 PF11951.8 EXF78478.1 - 3.9e-59 200.4 0.0 4.9e-59 200.1 0.0 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF78478.1 - 1.4e-07 31.5 14.5 2.6e-07 30.7 14.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.16 EXF78479.1 - 7.8e-15 54.6 43.0 2.5e-13 49.7 40.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF78479.1 - 2e-06 27.0 8.1 2e-06 27.0 8.1 2.2 2 0 0 2 2 2 1 Sugar (and other) transporter UNC-93 PF05978.16 EXF78479.1 - 0.00027 20.7 6.8 0.00027 20.7 6.8 2.1 2 0 0 2 2 2 1 Ion channel regulatory protein UNC-93 DAO PF01266.24 EXF78480.1 - 3e-45 155.3 0.3 3.5e-45 155.1 0.3 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EXF78480.1 - 0.00012 22.1 0.8 0.073 13.1 0.0 2.7 3 0 0 3 3 3 2 FAD-NAD(P)-binding Thi4 PF01946.17 EXF78480.1 - 0.0079 15.5 0.3 0.074 12.3 0.1 2.4 2 1 1 3 3 3 1 Thi4 family Pyr_redox_2 PF07992.14 EXF78480.1 - 0.013 14.8 0.7 1.3 8.2 0.7 2.5 2 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EXF78480.1 - 0.047 13.9 0.1 0.11 12.7 0.1 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 EXF78480.1 - 0.053 12.2 0.1 0.57 8.8 0.0 2.1 2 0 0 2 2 2 0 HI0933-like protein Hydrolase PF00702.26 EXF78481.1 - 3.8e-08 33.9 0.0 1e-07 32.5 0.0 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EXF78481.1 - 0.011 15.8 0.0 0.015 15.4 0.0 1.5 1 1 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 EXF78481.1 - 0.042 14.0 0.0 11 6.2 0.0 2.3 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase MFS_1 PF07690.16 EXF78482.1 - 2e-44 152.0 54.5 7.7e-42 143.5 30.2 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF78482.1 - 2.3e-12 46.5 10.9 2.3e-12 46.5 10.9 2.6 3 0 0 3 3 3 1 Sugar (and other) transporter OATP PF03137.20 EXF78482.1 - 5.9 5.1 14.7 0.12 10.6 3.3 3.2 2 1 0 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family SPC25 PF06703.11 EXF78482.1 - 6.2 6.6 7.0 0.3 10.9 0.5 2.0 2 0 0 2 2 2 0 Microsomal signal peptidase 25 kDa subunit (SPC25) p450 PF00067.22 EXF78483.1 - 6e-50 170.3 0.0 1.2e-49 169.3 0.0 1.3 1 1 0 1 1 1 1 Cytochrome P450 DIT1_PvcA PF05141.12 EXF78484.1 - 2.6e-104 348.6 0.0 3.3e-104 348.2 0.0 1.1 1 0 0 1 1 1 1 Pyoverdine/dityrosine biosynthesis protein DJ-1_PfpI PF01965.24 EXF78485.1 - 1.8e-16 60.4 0.0 2.6e-16 59.8 0.0 1.2 1 0 0 1 1 1 1 DJ-1/PfpI family Urm1 PF09138.11 EXF78486.1 - 2.7e-33 114.2 0.0 3.2e-33 114.0 0.0 1.0 1 0 0 1 1 1 1 Urm1 (Ubiquitin related modifier) ThiS PF02597.20 EXF78486.1 - 0.0007 20.2 0.1 0.0018 18.9 0.0 1.7 2 0 0 2 2 2 1 ThiS family WD40 PF00400.32 EXF78487.1 - 8.6e-31 105.5 17.2 0.00018 22.2 0.0 10.9 12 0 0 12 12 12 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EXF78487.1 - 3.8e-07 30.3 0.6 0.69 10.3 0.1 7.1 5 2 4 9 9 9 2 Anaphase-promoting complex subunit 4 WD40 domain SPT_ssu-like PF11779.8 EXF78488.1 - 5.5e-21 73.9 5.6 7.3e-21 73.5 5.6 1.2 1 0 0 1 1 1 1 Small subunit of serine palmitoyltransferase-like RF-1 PF00472.20 EXF78489.1 - 1.1e-22 80.1 8.6 2.4e-22 79.1 8.6 1.6 1 1 0 1 1 1 1 RF-1 domain S-antigen PF05756.11 EXF78489.1 - 0.55 10.6 2.2 0.91 9.9 2.2 1.3 1 0 0 1 1 1 0 S-antigen protein Actin PF00022.19 EXF78490.1 - 5.7e-150 499.4 0.0 2.1e-149 497.6 0.0 1.7 1 1 0 1 1 1 1 Actin Fes1 PF08609.10 EXF78492.1 - 1.5e-30 105.9 2.3 2e-30 105.5 0.9 1.8 2 0 0 2 2 2 1 Nucleotide exchange factor Fes1 HEAT_EZ PF13513.6 EXF78492.1 - 1.1e-06 29.0 1.2 5.4e-06 26.8 0.3 2.2 2 0 0 2 2 2 1 HEAT-like repeat Arm PF00514.23 EXF78492.1 - 1.4e-06 28.2 0.3 0.065 13.3 0.0 2.7 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 EXF78492.1 - 5.4e-06 26.7 0.9 1.5e-05 25.3 0.1 2.0 2 1 0 2 2 2 1 HEAT repeats HEAT PF02985.22 EXF78492.1 - 1.2e-05 25.2 0.2 0.089 13.1 0.1 2.9 2 0 0 2 2 2 2 HEAT repeat AAA_13 PF13166.6 EXF78492.1 - 0.17 10.5 0.0 0.31 9.6 0.0 1.3 2 0 0 2 2 2 0 AAA domain Ribosomal_L5_C PF00673.21 EXF78493.1 - 1e-24 86.5 0.0 1.5e-24 85.9 0.0 1.3 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 EXF78493.1 - 2.2e-07 31.1 0.2 3.6e-07 30.4 0.2 1.3 1 0 0 1 1 1 1 Ribosomal protein L5 UCH_1 PF13423.6 EXF78494.1 - 5.3e-39 134.7 0.0 1.8e-38 132.9 0.0 1.8 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase 6PF2K PF01591.18 EXF78495.1 - 7.6e-61 205.3 0.0 1.2e-60 204.6 0.0 1.3 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 EXF78495.1 - 2.1e-21 76.5 0.2 9.1e-21 74.4 0.2 1.9 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 EXF78495.1 - 0.006 16.7 0.0 0.05 13.8 0.0 2.2 2 0 0 2 2 2 1 AAA domain ZnuA PF01297.17 EXF78495.1 - 0.077 12.4 0.1 0.26 10.7 0.0 1.9 1 1 1 2 2 2 0 Zinc-uptake complex component A periplasmic Porin_3 PF01459.22 EXF78496.1 - 1.1e-87 294.0 1.0 1.2e-87 293.8 1.0 1.0 1 0 0 1 1 1 1 Eukaryotic porin NmrA PF05368.13 EXF78497.1 - 3.9e-20 72.4 0.1 5.1e-20 72.0 0.1 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EXF78497.1 - 9.4e-14 51.7 0.0 1.5e-13 51.1 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding Shikimate_DH PF01488.20 EXF78497.1 - 7.5e-05 22.8 0.0 0.00014 22.0 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase DapB_N PF01113.20 EXF78497.1 - 0.00018 21.6 0.2 0.00053 20.1 0.0 1.8 2 1 0 2 2 2 1 Dihydrodipicolinate reductase, N-terminus Epimerase PF01370.21 EXF78497.1 - 0.00052 19.5 0.1 0.051 13.0 0.0 2.5 3 0 0 3 3 3 1 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.24 EXF78497.1 - 0.046 14.1 0.0 0.086 13.3 0.0 1.4 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain HET PF06985.11 EXF78498.1 - 3.4e-12 46.9 5.5 8.3e-10 39.2 0.8 2.4 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) DUF3684 PF12449.8 EXF78499.1 - 0 1523.7 0.1 0 1523.3 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3684) HATPase_c_3 PF13589.6 EXF78499.1 - 8.3e-05 22.4 0.0 0.00028 20.7 0.0 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Myosin_tail_1 PF01576.19 EXF78499.1 - 0.17 9.7 6.1 0.26 9.1 6.1 1.1 1 0 0 1 1 1 0 Myosin tail Reprolysin_5 PF13688.6 EXF78499.1 - 0.82 9.8 2.8 2.4 8.2 2.8 1.8 1 1 0 1 1 1 0 Metallo-peptidase family M12 Sec16_C PF12931.7 EXF78500.1 - 1.6e-113 379.4 0.1 2.3e-113 378.9 0.1 1.2 1 0 0 1 1 1 1 Sec23-binding domain of Sec16 Sec16 PF12932.7 EXF78500.1 - 5.6e-35 120.5 0.0 1.9e-34 118.8 0.0 2.0 1 0 0 1 1 1 1 Vesicle coat trafficking protein Sec16 mid-region Sec16_N PF12935.7 EXF78500.1 - 1.8e-10 41.4 19.1 1.8e-10 41.4 19.1 5.3 3 3 1 4 4 4 2 Vesicle coat trafficking protein Sec16 N-terminus Nup96 PF12110.8 EXF78500.1 - 0.0061 15.7 0.0 0.014 14.6 0.0 1.6 1 0 0 1 1 1 1 Nuclear protein 96 PhoLip_ATPase_C PF16212.5 EXF78501.1 - 2.7e-50 171.4 6.2 2.7e-50 171.4 6.2 1.8 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EXF78501.1 - 7.7e-16 57.5 0.4 2e-15 56.2 0.4 1.7 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 EXF78501.1 - 6.4e-14 52.7 0.1 1.3e-07 32.1 0.0 3.3 3 1 0 3 3 3 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 EXF78501.1 - 1.8e-07 30.9 1.0 0.00074 19.1 0.1 2.9 2 0 0 2 2 2 2 E1-E2 ATPase Cation_ATPase PF13246.6 EXF78501.1 - 0.00011 22.2 0.0 0.0022 18.0 0.0 2.4 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EXF78501.1 - 0.0016 18.2 0.0 0.0038 17.0 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase FAD_binding_6 PF00970.24 EXF78502.1 - 0.00016 22.0 0.0 0.0072 16.7 0.0 2.8 1 1 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 EXF78502.1 - 0.0081 16.8 0.0 0.024 15.3 0.0 1.8 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain Suc_Fer-like PF06999.12 EXF78504.1 - 4.6e-58 196.3 0.0 6.8e-58 195.8 0.0 1.2 1 0 0 1 1 1 1 Sucrase/ferredoxin-like HGD-D PF06050.13 EXF78506.1 - 0.071 12.9 0.1 0.1 12.3 0.1 1.2 1 0 0 1 1 1 0 2-hydroxyglutaryl-CoA dehydratase, D-component HsbA PF12296.8 EXF78507.1 - 9.4e-26 90.6 3.4 9.4e-26 90.6 3.4 1.6 1 1 0 1 1 1 1 Hydrophobic surface binding protein A HWE_HK PF07536.14 EXF78507.1 - 0.014 16.1 0.1 0.048 14.4 0.0 2.0 2 1 1 3 3 3 0 HWE histidine kinase Carbpep_Y_N PF05388.11 EXF78507.1 - 0.028 15.0 0.1 0.063 13.8 0.1 1.5 1 0 0 1 1 1 0 Carboxypeptidase Y pro-peptide DUF4244 PF14029.6 EXF78507.1 - 0.04 13.3 0.7 0.12 11.9 0.7 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF4244) Dynein_C PF18199.1 EXF78507.1 - 0.067 12.4 0.0 0.18 11.0 0.0 1.6 1 1 0 1 1 1 0 Dynein heavy chain C-terminal domain Corona_S2 PF01601.16 EXF78507.1 - 0.2 10.1 4.5 0.45 8.9 4.6 1.6 1 1 0 1 1 1 0 Coronavirus S2 glycoprotein Glyco_hydro_3 PF00933.21 EXF78508.1 - 3.2e-47 161.5 0.0 5.1e-47 160.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.22 EXF78508.1 - 1e-40 139.9 0.0 1.6e-40 139.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.6 EXF78508.1 - 3.2e-17 62.4 0.2 7.7e-17 61.2 0.2 1.7 1 0 0 1 1 1 1 Fibronectin type III-like domain PA14 PF07691.12 EXF78508.1 - 1.3e-05 25.0 0.1 2.7e-05 24.0 0.1 1.5 1 0 0 1 1 1 1 PA14 domain DUF957 PF06117.11 EXF78508.1 - 0.035 13.7 0.0 0.1 12.2 0.0 1.7 1 0 0 1 1 1 0 Enterobacterial protein of unknown function (DUF957) Pantoate_ligase PF02569.15 EXF78508.1 - 0.13 11.5 0.0 0.22 10.7 0.0 1.3 1 0 0 1 1 1 0 Pantoate-beta-alanine ligase Aldo_ket_red PF00248.21 EXF78509.1 - 1.7e-43 148.9 0.0 2.1e-43 148.6 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family AA_permease PF00324.21 EXF78512.1 - 6.6e-120 400.9 47.9 8e-120 400.6 47.9 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EXF78512.1 - 1e-31 110.2 50.4 1.5e-31 109.7 50.4 1.2 1 0 0 1 1 1 1 Amino acid permease PQ-loop PF04193.14 EXF78513.1 - 6.9e-25 86.6 2.2 3.2e-17 62.0 0.2 2.9 2 1 0 2 2 2 2 PQ loop repeat Peptidase_U4 PF03419.13 EXF78513.1 - 0.46 9.7 10.2 1.9 7.7 10.2 1.8 1 1 0 1 1 1 0 Sporulation factor SpoIIGA An_peroxidase PF03098.15 EXF78514.1 - 4.2e-36 124.6 0.0 1.2e-24 86.8 0.0 3.7 1 1 1 2 2 2 2 Animal haem peroxidase p450 PF00067.22 EXF78514.1 - 3e-08 32.8 0.0 2.7e-06 26.4 0.0 2.2 2 0 0 2 2 2 2 Cytochrome P450 Acyl_transf_3 PF01757.22 EXF78515.1 - 2.9e-30 105.5 37.1 5.5e-30 104.6 34.4 2.3 2 1 0 2 2 2 1 Acyltransferase family OpgC_C PF10129.9 EXF78515.1 - 0.001 18.1 6.1 0.026 13.4 0.1 2.5 1 1 1 2 2 2 2 OpgC protein CReP_N PF10472.9 EXF78515.1 - 0.034 13.0 0.1 0.066 12.1 0.1 1.4 1 0 0 1 1 1 0 eIF2-alpha phosphatase phosphorylation constitutive repressor adh_short PF00106.25 EXF78516.1 - 3.9e-23 81.9 0.0 7.3e-19 68.0 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EXF78516.1 - 3.2e-16 59.6 0.0 1.7e-15 57.2 0.0 1.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF78516.1 - 0.0001 22.3 0.0 0.00015 21.7 0.0 1.3 1 0 0 1 1 1 1 KR domain DUF3328 PF11807.8 EXF78517.1 - 2.4e-49 168.1 0.4 3e-49 167.8 0.4 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) MF_alpha_N PF05436.11 EXF78518.1 - 0.059 13.3 0.2 0.076 12.9 0.2 1.1 1 0 0 1 1 1 0 Mating factor alpha precursor N-terminus Herpes_UL32 PF06070.11 EXF78519.1 - 1.1 7.0 10.5 1.1 6.9 9.6 1.4 1 1 0 1 1 1 0 Herpesvirus large structural phosphoprotein UL32 Thymidylate_kin PF02223.17 EXF78520.1 - 2.2e-45 154.6 0.0 2.3e-44 151.3 0.0 1.9 2 0 0 2 2 2 1 Thymidylate kinase AAA_28 PF13521.6 EXF78520.1 - 0.00035 20.8 0.0 0.00074 19.8 0.0 1.5 1 1 0 1 1 1 1 AAA domain KTI12 PF08433.10 EXF78520.1 - 0.057 12.9 0.0 0.094 12.1 0.0 1.4 1 1 0 1 1 1 0 Chromatin associated protein KTI12 COesterase PF00135.28 EXF78521.1 - 3.5e-67 227.4 0.0 6.6e-67 226.5 0.0 1.3 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EXF78521.1 - 1.7e-08 34.6 0.1 2.5e-08 34.0 0.1 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Ntox22 PF15527.6 EXF78521.1 - 0.049 13.7 0.1 0.12 12.5 0.1 1.6 1 0 0 1 1 1 0 Bacterial toxin 22 TYA PF01021.19 EXF78522.1 - 0.012 16.0 0.1 0.023 15.0 0.1 1.4 1 0 0 1 1 1 0 TYA transposon protein SAM_decarbox PF01536.16 EXF78523.1 - 1.2e-132 442.3 0.0 1.6e-132 441.9 0.0 1.1 1 0 0 1 1 1 1 Adenosylmethionine decarboxylase ParA PF10609.9 EXF78524.1 - 9.9e-92 306.8 0.0 1.4e-91 306.4 0.0 1.3 1 1 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 EXF78524.1 - 3.5e-11 43.3 0.0 3.9e-10 39.9 0.0 2.2 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MipZ PF09140.11 EXF78524.1 - 2.9e-07 30.0 0.0 5.7e-06 25.8 0.0 2.1 2 0 0 2 2 2 1 ATPase MipZ AAA_31 PF13614.6 EXF78524.1 - 2.9e-06 27.3 0.1 0.00026 20.9 0.1 2.2 2 0 0 2 2 2 1 AAA domain ArsA_ATPase PF02374.15 EXF78524.1 - 0.00011 21.5 1.1 0.00015 21.1 0.4 1.6 2 0 0 2 2 2 1 Anion-transporting ATPase AAA_25 PF13481.6 EXF78524.1 - 0.00087 18.9 0.1 0.0016 18.1 0.1 1.4 1 0 0 1 1 1 1 AAA domain MeaB PF03308.16 EXF78524.1 - 0.0011 18.0 0.5 0.0018 17.3 0.5 1.2 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_26 PF13500.6 EXF78524.1 - 0.0055 16.6 0.5 0.31 10.8 0.0 2.2 2 0 0 2 2 2 1 AAA domain CBP_BcsQ PF06564.12 EXF78524.1 - 0.018 14.5 0.5 0.053 13.0 0.5 1.8 1 1 0 1 1 1 0 Cellulose biosynthesis protein BcsQ Zeta_toxin PF06414.12 EXF78524.1 - 0.037 13.3 0.0 0.068 12.4 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin APS_kinase PF01583.20 EXF78524.1 - 0.057 13.3 0.1 0.095 12.6 0.1 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase Fer4_NifH PF00142.18 EXF78524.1 - 0.12 11.8 0.1 0.41 10.0 0.0 1.8 2 0 0 2 2 2 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family AAA_16 PF13191.6 EXF78524.1 - 0.16 12.3 0.4 0.46 10.8 0.3 1.7 2 0 0 2 2 2 0 AAA ATPase domain RsgA_GTPase PF03193.16 EXF78524.1 - 0.41 10.5 3.2 0.36 10.7 1.3 1.8 2 0 0 2 2 2 0 RsgA GTPase p450 PF00067.22 EXF78526.1 - 1.4e-94 317.5 0.0 1.6e-94 317.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Zn_clus PF00172.18 EXF78527.1 - 7.1e-19 67.7 27.7 2.9e-10 40.1 7.1 2.5 2 0 0 2 2 2 2 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EXF78527.1 - 8.9e-10 38.0 0.0 1.6e-09 37.2 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain NOB1_Zn_bind PF08772.11 EXF78528.1 - 2e-32 111.1 3.1 3.4e-32 110.4 3.1 1.4 1 0 0 1 1 1 1 Nin one binding (NOB1) Zn-ribbon like PIN_6 PF17146.4 EXF78528.1 - 3.1e-29 101.3 1.0 5.1e-29 100.6 0.0 1.9 2 0 0 2 2 2 1 PIN domain of ribonuclease PIN_5 PF08745.11 EXF78528.1 - 0.053 12.9 0.2 25 4.2 0.0 3.1 2 1 1 3 3 3 0 PINc domain ribonuclease zf-NADH-PPase PF09297.11 EXF78528.1 - 0.092 12.4 3.0 0.17 11.6 0.3 2.4 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain Peptidase_S64 PF08192.11 EXF78528.1 - 0.38 9.2 5.7 0.48 8.8 5.7 1.1 1 0 0 1 1 1 0 Peptidase family S64 Glyco_transf_41 PF13844.6 EXF78528.1 - 1.5 7.2 4.5 2.2 6.6 4.5 1.1 1 0 0 1 1 1 0 Glycosyl transferase family 41 Suf PF05843.14 EXF78528.1 - 2.8 7.9 6.6 4 7.4 6.6 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Presenilin PF01080.17 EXF78528.1 - 5.1 5.7 7.0 7.1 5.3 7.0 1.2 1 0 0 1 1 1 0 Presenilin Plasmodium_Vir PF05795.11 EXF78528.1 - 6.3 6.1 8.1 13 5.1 8.0 1.5 1 1 0 1 1 1 0 Plasmodium vivax Vir protein Nop10p PF04135.12 EXF78529.1 - 5.3e-22 77.6 0.1 6e-22 77.4 0.1 1.0 1 0 0 1 1 1 1 Nucleolar RNA-binding protein, Nop10p family DUF3328 PF11807.8 EXF78530.1 - 1.3e-19 70.9 0.8 5.1e-18 65.7 0.3 2.1 1 1 1 2 2 2 2 Domain of unknown function (DUF3328) NETI PF14044.6 EXF78531.1 - 0.029 14.1 0.0 29 4.5 0.0 3.3 3 0 0 3 3 3 0 NETI protein Bac_rhamnosid6H PF17389.2 EXF78532.1 - 6.2e-115 384.1 3.7 8.5e-115 383.6 3.7 1.2 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain Bac_rhamnosid_N PF08531.10 EXF78532.1 - 7.5e-58 195.2 0.0 1.6e-57 194.1 0.0 1.6 1 0 0 1 1 1 1 Alpha-L-rhamnosidase N-terminal domain Bac_rhamnosid PF05592.11 EXF78532.1 - 1.2e-32 111.9 0.0 2.7e-32 110.8 0.0 1.6 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase concanavalin-like domain Bac_rhamnosid_C PF17390.2 EXF78532.1 - 2.5e-19 68.8 0.5 3e-17 62.2 0.5 2.8 2 1 0 2 2 2 1 Bacterial alpha-L-rhamnosidase C-terminal domain MBD PF01429.19 EXF78532.1 - 0.085 12.6 0.0 2 8.2 0.0 2.8 3 0 0 3 3 3 0 Methyl-CpG binding domain SFTA2 PF15210.6 EXF78532.1 - 0.091 12.7 0.0 0.22 11.5 0.0 1.6 1 0 0 1 1 1 0 Surfactant-associated protein 2 adh_short PF00106.25 EXF78533.1 - 6.8e-43 146.4 0.0 1.1e-42 145.7 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF78533.1 - 1e-30 107.0 0.0 1.3e-30 106.7 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF78533.1 - 4.5e-09 36.5 0.0 1.3e-08 35.0 0.0 1.7 1 1 1 2 2 2 1 KR domain DUF1776 PF08643.10 EXF78533.1 - 7.9e-06 25.4 0.1 1.2e-05 24.8 0.1 1.3 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) NAD_binding_10 PF13460.6 EXF78533.1 - 8.7e-05 22.5 0.1 0.0003 20.7 0.0 1.8 2 0 0 2 2 2 1 NAD(P)H-binding Epimerase PF01370.21 EXF78533.1 - 0.012 15.1 0.0 0.018 14.5 0.0 1.5 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family 2-Hacid_dh_C PF02826.19 EXF78533.1 - 0.037 13.4 0.0 0.067 12.5 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ADH_zinc_N PF00107.26 EXF78533.1 - 0.044 13.8 0.0 0.13 12.3 0.0 1.7 2 0 0 2 2 2 0 Zinc-binding dehydrogenase RmlD_sub_bind PF04321.17 EXF78533.1 - 0.12 11.5 0.0 0.19 10.8 0.0 1.4 1 0 0 1 1 1 0 RmlD substrate binding domain MFS_1 PF07690.16 EXF78534.1 - 4.1e-32 111.5 20.6 3.4e-20 72.3 5.3 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EXF78534.1 - 3.7e-11 42.2 18.7 2.7e-05 22.9 1.0 3.3 3 1 1 4 4 4 3 MFS/sugar transport protein MFS_1_like PF12832.7 EXF78534.1 - 5e-10 38.8 13.5 7.2e-06 25.1 4.3 2.6 2 1 0 2 2 2 2 MFS_1 like family Sugar_tr PF00083.24 EXF78534.1 - 5.2e-05 22.3 6.8 7e-05 21.9 5.9 1.4 1 1 0 1 1 1 1 Sugar (and other) transporter OATP PF03137.20 EXF78534.1 - 0.12 10.7 6.6 2.5 6.3 1.9 2.8 3 0 0 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family FA_hydroxylase PF04116.13 EXF78536.1 - 4.3e-22 78.9 10.0 4.3e-22 78.9 10.0 2.3 2 0 0 2 2 2 2 Fatty acid hydroxylase superfamily GFO_IDH_MocA PF01408.22 EXF78537.1 - 2.8e-16 60.4 0.2 4.6e-16 59.7 0.2 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold OpuAC PF04069.12 EXF78537.1 - 0.0068 16.0 0.1 3.9 7.0 0.1 2.3 2 0 0 2 2 2 2 Substrate binding domain of ABC-type glycine betaine transport system Aldo_ket_red PF00248.21 EXF78538.1 - 8.7e-15 54.7 0.0 9e-07 28.4 0.0 2.1 2 0 0 2 2 2 2 Aldo/keto reductase family PNRC PF15365.6 EXF78538.1 - 4.2 7.3 8.3 0.37 10.7 1.6 2.5 2 0 0 2 2 2 0 Proline-rich nuclear receptor coactivator motif HTH_5 PF01022.20 EXF78540.1 - 0.012 15.5 0.0 0.019 14.8 0.0 1.2 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family SNF2_N PF00176.23 EXF78541.1 - 1.3e-19 70.1 0.0 1.9e-19 69.6 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain SRR1 PF07985.12 EXF78541.1 - 0.045 13.8 0.0 0.094 12.8 0.0 1.5 1 0 0 1 1 1 0 SRR1 NACHT PF05729.12 EXF78542.1 - 6.1e-08 32.8 0.1 1.7e-07 31.3 0.0 1.9 2 0 0 2 2 2 1 NACHT domain AAA_16 PF13191.6 EXF78542.1 - 1.4e-06 28.8 0.5 0.0011 19.3 0.0 3.5 3 0 0 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 EXF78542.1 - 0.00037 20.8 0.0 0.0081 16.4 0.0 2.8 2 1 0 2 2 2 1 AAA domain AAA PF00004.29 EXF78542.1 - 0.0034 17.8 0.5 0.05 14.0 0.0 2.8 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 EXF78542.1 - 0.012 15.2 0.0 0.029 13.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 EXF78542.1 - 0.023 14.1 0.0 0.13 11.6 0.0 2.1 1 1 0 1 1 1 0 KaiC PPV_E1_C PF00519.17 EXF78542.1 - 0.026 13.4 0.0 0.078 11.8 0.0 1.7 2 0 0 2 2 2 0 Papillomavirus helicase NB-ARC PF00931.22 EXF78542.1 - 0.027 13.6 0.0 0.1 11.8 0.0 2.0 2 0 0 2 2 2 0 NB-ARC domain DAP3 PF10236.9 EXF78542.1 - 0.04 13.1 1.2 1.9 7.5 0.0 2.3 1 1 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 RNA_helicase PF00910.22 EXF78542.1 - 0.057 13.8 0.0 0.13 12.7 0.0 1.6 1 0 0 1 1 1 0 RNA helicase RPN5_C PF18098.1 EXF78542.1 - 0.1 12.7 0.0 1.3 9.2 0.0 2.8 4 0 0 4 4 4 0 26S proteasome regulatory subunit RPN5 C-terminal domain Sigma54_activ_2 PF14532.6 EXF78542.1 - 0.13 12.3 0.0 8.9 6.4 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_33 PF13671.6 EXF78542.1 - 0.17 12.1 1.0 1.1 9.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain LMBR1 PF04791.16 EXF78543.1 - 0.0072 15.3 0.8 0.0074 15.3 0.8 1.2 1 0 0 1 1 1 1 LMBR1-like membrane protein Phytochelatin PF05023.14 EXF78543.1 - 0.026 13.8 0.6 0.046 12.9 0.6 1.4 1 0 0 1 1 1 0 Phytochelatin synthase Ribosomal_L12_N PF16320.5 EXF78543.1 - 0.04 13.6 0.6 0.083 12.6 0.6 1.5 1 0 0 1 1 1 0 Ribosomal protein L7/L12 dimerisation domain TFIIA PF03153.13 EXF78543.1 - 2.1 8.2 26.4 3.1 7.7 26.4 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit VTC PF09359.10 EXF78544.1 - 2.6e-91 305.8 0.4 5.7e-91 304.7 0.4 1.6 1 0 0 1 1 1 1 VTC domain DUF202 PF02656.15 EXF78544.1 - 4.1e-12 46.4 1.5 4.1e-12 46.4 1.5 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF202) SPX PF03105.19 EXF78544.1 - 1.6e-07 31.6 27.5 0.00027 21.0 1.1 4.3 2 1 2 4 4 4 3 SPX domain DUF3295 PF11702.8 EXF78544.1 - 0.041 13.2 5.3 0.078 12.3 5.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) FGGY_C PF02782.16 EXF78545.1 - 7.1e-47 159.7 0.4 1.2e-46 159.0 0.4 1.3 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 EXF78545.1 - 1.2e-16 61.0 0.7 4.1e-15 56.0 0.7 3.0 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain BcrAD_BadFG PF01869.20 EXF78545.1 - 0.11 12.0 0.1 0.67 9.4 0.0 2.0 2 0 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family Myb_DNA-binding PF00249.31 EXF78546.1 - 2.6e-16 59.5 1.7 7.3e-09 35.7 0.2 2.2 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EXF78546.1 - 1e-09 38.5 0.3 0.00082 19.6 0.0 2.6 1 1 1 2 2 2 2 Myb-like DNA-binding domain Presenilin PF01080.17 EXF78546.1 - 0.54 9.0 6.5 0.6 8.8 6.5 1.3 1 0 0 1 1 1 0 Presenilin Glyco_hydro_16 PF00722.21 EXF78547.1 - 6.9e-45 152.7 4.1 6.9e-45 152.7 4.1 1.7 2 0 0 2 2 2 1 Glycosyl hydrolases family 16 Chitin_bind_1 PF00187.19 EXF78547.1 - 5.7 7.5 21.6 0.076 13.5 13.4 2.1 2 0 0 2 2 2 0 Chitin recognition protein NAD_binding_10 PF13460.6 EXF78548.1 - 2.4e-19 69.9 0.0 2.9e-19 69.7 0.0 1.1 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EXF78548.1 - 0.011 15.3 0.0 0.018 14.6 0.0 1.4 2 0 0 2 2 2 0 NmrA-like family Lactonase PF10282.9 EXF78549.1 - 1.1e-54 186.0 0.2 3e-54 184.6 0.2 1.6 1 1 0 1 1 1 1 Lactonase, 7-bladed beta-propeller SBP56 PF05694.11 EXF78549.1 - 0.0018 17.2 0.0 0.51 9.1 0.0 2.2 2 0 0 2 2 2 2 56kDa selenium binding protein (SBP56) Cytochrom_D1 PF02239.16 EXF78549.1 - 0.03 12.8 0.1 0.74 8.3 0.0 2.3 2 1 1 3 3 3 0 Cytochrome D1 heme domain DUF4604 PF15377.6 EXF78550.1 - 9.6e-34 117.3 16.1 1.1e-33 117.1 16.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4604) COX5B PF01215.19 EXF78551.1 - 7e-56 187.4 0.0 9e-56 187.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Vb PKcGMP_CC PF16808.5 EXF78552.1 - 0.00012 21.8 8.8 0.0005 19.8 3.7 2.5 2 0 0 2 2 2 1 Coiled-coil N-terminus of cGMP-dependent protein kinase HMMR_N PF15905.5 EXF78552.1 - 0.00033 20.2 5.3 0.00033 20.2 5.3 1.6 2 0 0 2 2 2 1 Hyaluronan mediated motility receptor N-terminal ARA70 PF12489.8 EXF78552.1 - 0.0023 18.1 8.5 0.11 12.7 0.3 3.2 2 1 1 3 3 3 2 Nuclear coactivator ERM PF00769.19 EXF78552.1 - 0.0029 17.5 4.1 0.0029 17.5 4.1 2.3 2 0 0 2 2 2 1 Ezrin/radixin/moesin family Spc7 PF08317.11 EXF78552.1 - 0.011 14.7 6.8 0.019 13.8 6.8 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein Tnp_22_trimer PF17489.2 EXF78552.1 - 0.017 15.0 2.2 4.2 7.4 0.2 2.9 2 0 0 2 2 2 0 L1 transposable element trimerization domain DUF641 PF04859.12 EXF78552.1 - 0.029 14.7 7.6 1.1 9.5 3.2 2.9 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) LRS4 PF10422.9 EXF78552.1 - 0.033 13.8 11.2 0.023 14.3 3.0 2.4 2 0 0 2 2 2 0 Monopolin complex subunit LRS4 CC2-LZ PF16516.5 EXF78552.1 - 0.039 14.3 6.2 0.067 13.6 3.3 2.6 1 1 1 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator DUF1192 PF06698.11 EXF78552.1 - 0.09 12.8 6.8 0.2 11.7 1.9 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) AAA_13 PF13166.6 EXF78552.1 - 0.17 10.5 3.8 0.32 9.6 3.8 1.4 1 0 0 1 1 1 0 AAA domain Fib_alpha PF08702.10 EXF78552.1 - 1.4 9.1 11.1 0.073 13.3 4.9 2.1 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF812 PF05667.11 EXF78552.1 - 2.8 6.7 16.4 0.031 13.2 3.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF812) Atg14 PF10186.9 EXF78552.1 - 9 5.3 15.4 0.039 13.1 5.8 1.8 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 4HBT_3 PF13622.6 EXF78553.1 - 8.4e-22 78.6 0.0 1e-21 78.3 0.0 1.1 1 0 0 1 1 1 1 Thioesterase-like superfamily DUF5560 PF17715.1 EXF78554.1 - 6.7 6.1 15.4 3.6 7.0 2.2 2.6 3 0 0 3 3 3 0 Family of unknown function (DUF5560) Amino_oxidase PF01593.24 EXF78555.1 - 1.2e-60 206.1 0.4 2.1e-60 205.3 0.4 1.4 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EXF78555.1 - 3.4e-16 59.2 0.7 7e-16 58.2 0.2 1.8 2 0 0 2 2 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EXF78555.1 - 2.4e-10 40.6 1.4 5.2e-10 39.4 1.4 1.6 1 1 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 EXF78555.1 - 2.4e-07 29.8 0.1 0.00015 20.6 0.1 2.2 2 0 0 2 2 2 2 HI0933-like protein FAD_binding_2 PF00890.24 EXF78555.1 - 1.5e-06 27.6 0.5 7.5e-06 25.3 0.8 2.0 2 0 0 2 2 2 1 FAD binding domain Pyr_redox PF00070.27 EXF78555.1 - 1.5e-06 28.7 1.5 0.0009 19.8 0.1 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EXF78555.1 - 2.4e-06 27.0 0.7 0.00064 19.0 0.1 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EXF78555.1 - 5.2e-06 26.1 1.0 6.3e-06 25.8 0.3 1.5 2 0 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.17 EXF78555.1 - 9.9e-05 21.7 0.2 0.00018 20.8 0.2 1.3 1 0 0 1 1 1 1 Thi4 family FAD_binding_3 PF01494.19 EXF78555.1 - 0.00042 19.7 0.1 0.0053 16.0 0.1 2.1 2 0 0 2 2 2 1 FAD binding domain GIDA PF01134.22 EXF78555.1 - 0.00067 18.8 0.3 0.0012 18.1 0.3 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A NAD_binding_9 PF13454.6 EXF78555.1 - 0.0081 16.2 0.2 3.4 7.6 0.0 2.5 2 0 0 2 2 2 2 FAD-NAD(P)-binding Lycopene_cycl PF05834.12 EXF78555.1 - 0.0082 15.2 0.6 0.019 14.0 0.5 1.6 2 0 0 2 2 2 1 Lycopene cyclase protein Pyr_redox_3 PF13738.6 EXF78555.1 - 0.019 14.2 0.9 0.13 11.5 0.1 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase OHCU_decarbox PF09349.10 EXF78556.1 - 2.6e-42 144.9 0.5 3e-42 144.7 0.5 1.0 1 0 0 1 1 1 1 OHCU decarboxylase Dor1 PF04124.12 EXF78556.1 - 0.0072 15.0 0.3 0.0083 14.9 0.3 1.1 1 0 0 1 1 1 1 Dor1-like family LRR_12 PF18837.1 EXF78556.1 - 4.5 7.0 8.1 13 5.6 0.0 3.0 4 0 0 4 4 4 0 Leucine-rich repeat Prp19 PF08606.11 EXF78557.1 - 8.6e-33 112.1 2.6 1.9e-32 111.1 2.6 1.6 1 0 0 1 1 1 1 Prp19/Pso4-like ANAPC4_WD40 PF12894.7 EXF78557.1 - 2.4e-12 47.0 0.0 3.4e-06 27.3 0.0 4.1 1 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EXF78557.1 - 1.2e-10 41.8 0.6 0.01 16.7 0.0 5.1 5 0 0 5 5 5 3 WD domain, G-beta repeat Coatomer_WDAD PF04053.14 EXF78557.1 - 6.4e-06 25.5 0.0 0.067 12.2 0.0 2.1 1 1 1 2 2 2 2 Coatomer WD associated region eIF2A PF08662.11 EXF78557.1 - 0.00053 19.9 0.0 0.83 9.5 0.0 2.3 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A V_ATPase_I_N PF18670.1 EXF78557.1 - 0.0012 19.2 0.4 0.0039 17.6 0.4 1.9 2 0 0 2 2 2 1 V-type ATPase subunit I, N-terminal domain zf-Nse PF11789.8 EXF78557.1 - 0.0024 17.7 0.0 0.0058 16.4 0.0 1.7 1 1 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit U-box PF04564.15 EXF78557.1 - 0.0042 17.2 0.0 0.0086 16.2 0.0 1.5 1 0 0 1 1 1 1 U-box domain HPS3_N PF14761.6 EXF78557.1 - 0.016 14.8 0.0 0.52 9.8 0.0 2.4 2 1 0 2 2 2 0 Hermansky-Pudlak syndrome 3 Lactonase PF10282.9 EXF78557.1 - 0.018 14.3 0.0 0.092 12.0 0.0 2.1 1 1 1 2 2 2 0 Lactonase, 7-bladed beta-propeller VID27 PF08553.10 EXF78557.1 - 0.029 13.4 0.6 0.17 10.9 0.1 2.1 2 0 0 2 2 2 0 VID27 C-terminal WD40-like domain zf-RING_UBOX PF13445.6 EXF78558.1 - 0.00021 21.2 0.9 0.00065 19.7 0.9 1.8 1 1 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 EXF78558.1 - 0.00048 20.0 1.1 0.0012 18.8 1.1 1.7 1 1 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EXF78558.1 - 0.0029 17.4 1.5 0.019 14.8 0.3 2.2 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 EXF78558.1 - 0.023 14.5 0.5 0.054 13.4 0.5 1.6 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EXF78558.1 - 0.12 12.3 2.6 0.25 11.3 0.4 2.1 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EXF78558.1 - 0.24 11.7 2.4 0.54 10.6 0.6 2.1 2 0 0 2 2 2 0 Ring finger domain EP400_N PF15790.5 EXF78558.1 - 0.38 9.5 7.4 0.61 8.9 7.4 1.3 1 0 0 1 1 1 0 E1A-binding protein p400, N-terminal zf-C3HC4_2 PF13923.6 EXF78558.1 - 0.42 10.5 3.5 0.16 11.9 0.3 1.8 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Stealth_CR4 PF17103.5 EXF78559.1 - 0.1 12.5 0.2 0.52 10.2 0.0 2.3 2 0 0 2 2 2 0 Stealth protein CR4, conserved region 4 Borrelia_P83 PF05262.11 EXF78559.1 - 2.6 6.5 15.2 1.2 7.6 11.9 1.8 2 0 0 2 2 2 0 Borrelia P83/100 protein WD40 PF00400.32 EXF78560.1 - 1.9e-15 56.9 6.3 1.6e-06 28.7 0.1 4.7 4 0 0 4 4 4 3 WD domain, G-beta repeat CAF1C_H4-bd PF12265.8 EXF78560.1 - 1.3e-13 51.0 0.0 5.6e-13 48.9 0.0 2.2 1 0 0 1 1 1 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex ANAPC4_WD40 PF12894.7 EXF78560.1 - 1.8e-09 37.7 0.5 0.005 17.1 0.1 4.2 3 1 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain CBM_1 PF00734.18 EXF78562.1 - 1.7e-08 34.3 10.0 1.7e-08 34.3 10.0 2.0 2 0 0 2 2 2 1 Fungal cellulose binding domain Toxin_7 PF05980.12 EXF78562.1 - 0.17 12.2 0.9 0.3 11.4 0.9 1.4 1 0 0 1 1 1 0 Toxin 7 Amidoligase_2 PF12224.8 EXF78563.1 - 1.5e-16 60.8 0.0 1e-15 58.1 0.0 1.9 1 1 0 1 1 1 1 Putative amidoligase enzyme Thioredoxin PF00085.20 EXF78564.1 - 5.8e-24 84.1 0.0 9.4e-24 83.4 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin OST3_OST6 PF04756.13 EXF78564.1 - 3.3e-06 26.7 0.0 3.4e-06 26.6 0.0 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 EXF78564.1 - 7e-06 26.4 0.1 4.2e-05 23.9 0.1 2.1 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 EXF78564.1 - 5.4e-05 23.5 0.0 0.00036 20.8 0.0 1.9 1 1 0 1 1 1 1 Thioredoxin-like TraF PF13728.6 EXF78564.1 - 0.0081 16.0 1.8 0.03 14.1 0.0 2.0 2 0 0 2 2 2 1 F plasmid transfer operon protein Thioredoxin_7 PF13899.6 EXF78564.1 - 0.0088 16.2 0.0 0.0088 16.2 0.0 2.0 2 0 0 2 2 2 1 Thioredoxin-like HyaE PF07449.11 EXF78564.1 - 0.065 13.2 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE Thioredoxin_5 PF13743.6 EXF78564.1 - 0.14 11.9 0.0 0.37 10.5 0.0 1.8 1 1 1 2 2 2 0 Thioredoxin Thioredoxin_9 PF14595.6 EXF78564.1 - 0.16 11.8 0.0 0.44 10.3 0.0 1.7 1 1 1 2 2 2 0 Thioredoxin DUF5633 PF18656.1 EXF78564.1 - 4.1 7.4 10.2 3.1 7.8 0.0 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5633) WD40 PF00400.32 EXF78565.1 - 1.8e-26 91.9 13.7 9.5e-07 29.4 0.1 7.0 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EXF78565.1 - 6.1e-05 23.2 0.6 0.38 11.1 0.0 4.9 2 1 3 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EXF78565.1 - 0.0059 15.6 5.4 0.052 12.5 0.4 3.4 1 1 0 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Nudix_N_2 PF14803.6 EXF78565.1 - 0.49 10.4 1.7 1.5 8.8 1.7 1.8 1 0 0 1 1 1 0 Nudix N-terminal eRF1_1 PF03463.15 EXF78566.1 - 5.6e-42 142.8 0.0 9.5e-42 142.0 0.0 1.4 1 0 0 1 1 1 1 eRF1 domain 1 eRF1_2 PF03464.15 EXF78566.1 - 4.3e-19 69.1 0.0 8.3e-19 68.2 0.0 1.5 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 EXF78566.1 - 1.3e-15 57.8 0.0 2.4e-15 57.0 0.0 1.5 1 0 0 1 1 1 1 eRF1 domain 3 Aldo_ket_red PF00248.21 EXF78567.1 - 2.5e-37 128.7 0.0 2.3e-26 92.7 0.0 2.0 1 1 1 2 2 2 2 Aldo/keto reductase family NmrA PF05368.13 EXF78569.1 - 9.9e-14 51.5 0.0 1.3e-13 51.1 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EXF78569.1 - 6.1e-12 45.8 0.1 1e-11 45.0 0.1 1.4 1 0 0 1 1 1 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 EXF78569.1 - 6.5e-07 29.7 0.0 1.2e-06 28.8 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Epimerase PF01370.21 EXF78569.1 - 0.0005 19.6 0.1 0.0007 19.1 0.1 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family DapB_N PF01113.20 EXF78569.1 - 0.0047 17.0 0.7 0.01 16.0 0.7 1.6 1 1 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus ApbA PF02558.16 EXF78569.1 - 0.0086 15.7 0.2 0.015 15.0 0.2 1.4 1 1 0 1 1 1 1 Ketopantoate reductase PanE/ApbA KR PF08659.10 EXF78569.1 - 0.011 15.7 0.5 0.022 14.6 0.5 1.5 1 1 0 1 1 1 0 KR domain Shikimate_DH PF01488.20 EXF78569.1 - 0.051 13.7 0.1 0.088 12.9 0.1 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Semialdhyde_dh PF01118.24 EXF78569.1 - 0.059 13.8 0.2 0.29 11.6 0.3 2.0 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain YjeF_N PF03853.15 EXF78569.1 - 0.13 12.1 0.1 0.55 10.1 0.1 1.9 1 1 0 1 1 1 0 YjeF-related protein N-terminus adh_short PF00106.25 EXF78569.1 - 0.2 11.1 3.1 0.46 9.9 0.5 2.1 1 1 1 2 2 2 0 short chain dehydrogenase Sigma54_activ_2 PF14532.6 EXF78569.1 - 0.2 11.8 0.0 0.35 11.0 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain p450 PF00067.22 EXF78570.1 - 1.6e-46 159.1 0.0 2.2e-46 158.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 zf-C2H2 PF00096.26 EXF78571.1 - 1.7e-07 31.3 47.8 0.00022 21.5 4.7 6.8 6 0 0 6 6 6 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EXF78571.1 - 0.00073 20.2 49.4 0.013 16.2 3.1 7.3 7 0 0 7 7 7 3 C2H2-type zinc finger FOXP-CC PF16159.5 EXF78571.1 - 0.058 14.0 0.7 0.058 14.0 0.7 5.2 4 1 1 5 5 5 0 FOXP coiled-coil domain zf-C2H2_8 PF15909.5 EXF78571.1 - 2.8 8.3 12.0 1.1 9.6 0.5 3.7 2 2 2 4 4 4 0 C2H2-type zinc ribbon Cyt-b5 PF00173.28 EXF78573.1 - 8.9e-11 41.8 0.1 1e-10 41.6 0.1 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain TPR_12 PF13424.6 EXF78574.1 - 8.7e-10 38.8 2.9 0.0016 18.7 0.1 3.6 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 EXF78574.1 - 8.8e-06 25.5 0.7 0.017 15.2 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 EXF78574.1 - 0.00013 21.6 1.1 0.32 10.9 0.0 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 EXF78574.1 - 0.0021 18.1 0.4 0.34 11.2 0.0 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_10 PF13374.6 EXF78574.1 - 0.0022 17.8 1.0 0.11 12.4 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 EXF78574.1 - 0.0039 17.1 0.3 2.2 8.5 0.0 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_21 PF09976.9 EXF78574.1 - 0.092 12.4 0.0 0.54 9.9 0.0 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat-like domain PRIMA1 PF16101.5 EXF78574.1 - 0.12 12.4 4.5 0.33 11.0 4.5 1.7 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 ANAPC3 PF12895.7 EXF78574.1 - 0.13 12.5 0.2 0.68 10.2 0.0 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 Mito_fiss_reg PF05308.11 EXF78574.1 - 0.31 11.1 2.5 0.68 10.0 2.5 1.5 1 0 0 1 1 1 0 Mitochondrial fission regulator CAP_N PF01213.19 EXF78574.1 - 0.41 10.1 6.0 0.56 9.6 4.8 1.7 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal TPR_6 PF13174.6 EXF78574.1 - 0.53 11.0 2.3 12 6.8 0.1 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat bZIP_1 PF00170.21 EXF78576.1 - 1.6e-05 24.9 5.8 1.6e-05 24.9 5.8 1.6 2 0 0 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.15 EXF78576.1 - 7e-05 22.8 3.7 7e-05 22.8 3.7 1.6 2 0 0 2 2 2 1 Basic region leucine zipper PKcGMP_CC PF16808.5 EXF78576.1 - 0.058 13.3 1.2 0.097 12.5 1.2 1.3 1 0 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase SHE3 PF17078.5 EXF78576.1 - 0.063 13.0 1.3 0.099 12.3 1.3 1.2 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 bZIP_Maf PF03131.17 EXF78576.1 - 0.11 13.1 7.5 0.2 12.2 7.5 1.4 1 0 0 1 1 1 0 bZIP Maf transcription factor HABP4_PAI-RBP1 PF04774.15 EXF78577.1 - 0.19 12.6 3.0 0.28 12.0 3.0 1.6 1 1 0 1 1 1 0 Hyaluronan / mRNA binding family Fis1_TPR_C PF14853.6 EXF78578.1 - 0.032 14.3 0.0 0.059 13.5 0.0 1.4 1 0 0 1 1 1 0 Fis1 C-terminal tetratricopeptide repeat REPA_OB_2 PF16900.5 EXF78578.1 - 0.045 13.7 0.0 0.12 12.3 0.0 1.7 1 0 0 1 1 1 0 Replication protein A OB domain CFEM PF05730.11 EXF78579.1 - 8.5e-08 32.2 4.9 1.7e-07 31.3 4.9 1.5 1 0 0 1 1 1 1 CFEM domain Antimicrobial_4 PF08024.11 EXF78579.1 - 8.5 6.6 6.0 0.76 9.9 0.3 2.1 2 0 0 2 2 2 0 Ant antimicrobial peptide BCAS2 PF05700.11 EXF78580.1 - 1.2e-57 194.9 1.4 1.5e-57 194.7 1.4 1.0 1 0 0 1 1 1 1 Breast carcinoma amplified sequence 2 (BCAS2) cNMP_binding PF00027.29 EXF78581.1 - 2.4e-40 136.5 0.0 5.2e-21 74.5 0.0 2.3 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain CDC50 PF03381.15 EXF78582.1 - 1.5e-104 349.5 0.2 1.8e-104 349.2 0.2 1.1 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family Asp4 PF16996.5 EXF78582.1 - 0.086 12.6 1.2 0.25 11.1 1.2 1.8 1 0 0 1 1 1 0 Accessory secretory protein Sec Asp4 FACT-Spt16_Nlob PF14826.6 EXF78583.1 - 2e-56 190.2 1.3 9.4e-56 188.1 1.3 2.3 1 0 0 1 1 1 1 FACT complex subunit SPT16 N-terminal lobe domain SPT16 PF08644.11 EXF78583.1 - 1.9e-54 183.9 0.1 1.9e-54 183.9 0.1 2.4 2 0 0 2 2 2 1 FACT complex subunit (SPT16/CDC68) Peptidase_M24 PF00557.24 EXF78583.1 - 7.4e-26 91.1 0.0 1.5e-25 90.1 0.0 1.5 1 0 0 1 1 1 1 Metallopeptidase family M24 Rtt106 PF08512.12 EXF78583.1 - 4.5e-16 59.0 1.2 1.6e-15 57.3 0.2 2.5 2 0 0 2 2 2 1 Histone chaperone Rttp106-like CMD PF02627.20 EXF78584.1 - 6.4e-09 35.7 0.0 8e-08 32.2 0.0 2.1 2 0 0 2 2 2 1 Carboxymuconolactone decarboxylase family CsbD PF05532.12 EXF78586.1 - 1.7e-15 56.6 23.2 2.3e-11 43.4 4.9 3.7 2 1 1 3 3 3 3 CsbD-like Aminotran_5 PF00266.19 EXF78587.1 - 3.7e-90 302.6 0.0 4.6e-90 302.3 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 EXF78587.1 - 5.3e-05 22.7 0.0 0.00016 21.1 0.0 1.8 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.21 EXF78587.1 - 6.1e-05 22.4 0.0 9.6e-05 21.8 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Pyridoxal_deC PF00282.19 EXF78587.1 - 0.0075 15.0 0.0 0.012 14.3 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Cys_Met_Meta_PP PF01053.20 EXF78587.1 - 0.064 11.8 0.0 0.095 11.2 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme B12-binding PF02310.19 EXF78587.1 - 0.081 13.0 0.0 0.35 10.9 0.0 2.0 2 0 0 2 2 2 0 B12 binding domain BAR PF03114.18 EXF78588.1 - 8.1e-70 235.2 8.3 1.1e-69 234.8 8.3 1.1 1 0 0 1 1 1 1 BAR domain SH3_1 PF00018.28 EXF78588.1 - 1.1e-15 57.0 0.1 2.4e-15 55.9 0.1 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EXF78588.1 - 3e-14 52.6 0.0 5.2e-14 51.8 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EXF78588.1 - 1.1e-10 41.0 0.3 6.1e-10 38.6 0.0 2.3 3 0 0 3 3 3 1 Variant SH3 domain TMPIT PF07851.13 EXF78588.1 - 0.038 13.2 5.4 1.7 7.8 0.0 2.2 1 1 1 2 2 2 0 TMPIT-like protein F-box PF00646.33 EXF78589.1 - 1.2e-06 28.2 0.1 3e-06 27.0 0.1 1.6 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EXF78589.1 - 0.00019 21.3 0.1 0.00061 19.6 0.0 1.9 2 0 0 2 2 2 1 F-box-like F-box_4 PF15966.5 EXF78589.1 - 0.015 15.2 0.0 0.028 14.3 0.0 1.4 1 0 0 1 1 1 0 F-box MOSC PF03473.17 EXF78590.1 - 7.3e-26 90.7 0.0 2e-25 89.3 0.0 1.8 1 0 0 1 1 1 1 MOSC domain Fer2 PF00111.27 EXF78590.1 - 1.1e-10 41.4 1.0 2.3e-10 40.3 1.0 1.5 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain NAD_binding_1 PF00175.21 EXF78590.1 - 2.7e-05 24.8 0.3 0.00039 21.0 0.0 2.7 2 1 0 2 2 2 1 Oxidoreductase NAD-binding domain 3-alpha PF03475.14 EXF78590.1 - 0.00012 21.9 0.1 0.00022 21.1 0.1 1.5 1 0 0 1 1 1 1 3-alpha domain RRP7 PF12923.7 EXF78591.1 - 6.1e-30 103.8 14.9 6.1e-30 103.8 14.9 1.8 2 0 0 2 2 2 1 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain RRM_Rrp7 PF17799.1 EXF78591.1 - 1.9e-16 60.3 0.0 3.9e-16 59.3 0.0 1.5 1 0 0 1 1 1 1 Rrp7 RRM-like N-terminal domain Usp PF00582.26 EXF78591.1 - 0.5 10.9 6.2 0.7 10.4 0.3 2.7 2 1 1 3 3 3 0 Universal stress protein family Glyco_hydro_16 PF00722.21 EXF78592.1 - 0.087 12.3 0.1 0.087 12.3 0.1 3.3 2 2 0 2 2 2 0 Glycosyl hydrolases family 16 SH2_2 PF14633.6 EXF78593.1 - 1.1e-83 279.9 0.0 1.1e-83 279.9 0.0 1.9 2 0 0 2 2 2 1 SH2 domain HTH_44 PF14641.6 EXF78593.1 - 2e-39 134.6 1.1 6.7e-39 132.9 1.1 1.9 1 0 0 1 1 1 1 Helix-turn-helix DNA-binding domain of SPT6 HHH_7 PF14635.6 EXF78593.1 - 1.5e-30 105.6 0.0 3.4e-30 104.5 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix motif YqgF PF14639.6 EXF78593.1 - 3.1e-29 101.7 0.0 1.7e-28 99.3 0.0 2.4 2 0 0 2 2 2 1 Holliday-junction resolvase-like of SPT6 SPT6_acidic PF14632.6 EXF78593.1 - 6.5e-20 71.5 33.2 6.5e-20 71.5 33.2 7.6 4 1 4 8 8 8 1 Acidic N-terminal SPT6 HHH_9 PF17674.1 EXF78593.1 - 4.3e-06 27.5 6.1 2.2e-05 25.3 2.0 4.2 3 1 0 3 3 3 1 HHH domain SH2 PF00017.24 EXF78593.1 - 0.00011 22.2 0.0 0.0003 20.8 0.0 1.8 1 0 0 1 1 1 1 SH2 domain HHH_3 PF12836.7 EXF78593.1 - 0.00035 20.8 0.0 0.001 19.3 0.0 1.8 1 0 0 1 1 1 1 Helix-hairpin-helix motif PSD4 PF07631.11 EXF78593.1 - 0.076 13.6 3.3 1.2 9.7 0.0 3.5 3 1 0 3 3 3 0 Protein of unknown function (DUF1592) Pkinase PF00069.25 EXF78594.1 - 2.3e-64 217.3 0.0 3e-64 216.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF78594.1 - 6.2e-40 137.1 0.0 8e-40 136.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EXF78594.1 - 0.00017 20.5 0.0 0.00027 19.8 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EXF78594.1 - 0.0005 19.5 0.0 0.001 18.4 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EXF78594.1 - 0.08 11.9 0.0 0.11 11.4 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Seadorna_VP7 PF07387.11 EXF78594.1 - 0.13 11.3 0.0 0.19 10.7 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 RIO1 PF01163.22 EXF78594.1 - 0.2 11.3 0.1 1.4 8.4 0.0 2.0 2 0 0 2 2 2 0 RIO1 family HAD_2 PF13419.6 EXF78595.1 - 1.4e-10 41.6 0.0 8.4e-10 39.0 0.0 1.9 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EXF78595.1 - 1.3e-08 35.4 0.0 1.7e-08 35.0 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EXF78595.1 - 2.7e-06 27.4 0.4 4.7e-06 26.6 0.4 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like HAD PF12710.7 EXF78595.1 - 0.0089 16.4 0.0 0.012 16.0 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase FUSC_2 PF13515.6 EXF78596.1 - 8.6e-26 90.5 9.5 8.6e-26 90.5 9.5 2.6 2 0 0 2 2 2 1 Fusaric acid resistance protein-like FUSC PF04632.12 EXF78596.1 - 4.3e-05 22.3 0.5 4.3e-05 22.3 0.5 2.6 3 0 0 3 3 3 1 Fusaric acid resistance protein family ArAE_2 PF10334.9 EXF78596.1 - 0.012 15.4 0.0 0.042 13.7 0.0 1.9 1 0 0 1 1 1 0 Aromatic acid exporter family member 2 ALMT PF11744.8 EXF78596.1 - 1.5 7.6 21.1 33 3.1 0.0 4.4 4 1 0 4 4 4 0 Aluminium activated malate transporter PNTB_4TM PF12769.7 EXF78596.1 - 1.6 9.2 7.9 0.67 10.5 2.2 3.1 3 0 0 3 3 3 0 4TM region of pyridine nucleotide transhydrogenase, mitoch FlxA PF14282.6 EXF78597.1 - 0.011 15.7 1.1 0.026 14.5 1.1 1.6 1 0 0 1 1 1 0 FlxA-like protein Nmad5 PF18757.1 EXF78597.1 - 0.15 12.3 0.0 0.27 11.4 0.0 1.4 1 0 0 1 1 1 0 Nucleotide modification associated domain 5 Ribosomal_L16 PF00252.18 EXF78599.1 - 2.3e-45 153.8 0.1 2.9e-45 153.5 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e Ribosomal_L7Ae PF01248.26 EXF78600.1 - 1.5e-23 82.3 0.0 1.8e-23 82.1 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family FapA PF03961.13 EXF78601.1 - 0.13 10.8 14.9 0.016 13.8 9.7 1.9 2 0 0 2 2 2 0 Flagellar Assembly Protein A Herpes_UL6 PF01763.16 EXF78601.1 - 0.22 10.0 5.7 0.41 9.1 5.7 1.4 1 0 0 1 1 1 0 Herpesvirus UL6 like DUF4615 PF15393.6 EXF78601.1 - 1.2 9.7 12.4 0.12 13.0 6.4 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4615) DotU PF09850.9 EXF78601.1 - 1.6 8.4 5.2 8.5 6.0 1.3 2.4 1 1 0 2 2 2 0 Type VI secretion system protein DotU Fez1 PF06818.15 EXF78601.1 - 2.3 8.6 32.5 0.18 12.2 19.4 2.4 2 0 0 2 2 2 0 Fez1 Laminin_II PF06009.12 EXF78601.1 - 3.2 7.8 17.3 0.17 11.9 5.9 3.1 2 1 1 3 3 3 0 Laminin Domain II Golgin_A5 PF09787.9 EXF78601.1 - 6 6.2 36.5 0.097 12.1 20.6 2.2 2 0 0 2 2 2 0 Golgin subfamily A member 5 MIF4G_like_2 PF09090.11 EXF78601.1 - 7.4 6.0 15.5 5 6.5 0.5 2.6 2 0 0 2 2 2 0 MIF4G like DUF953 PF06110.11 EXF78602.1 - 1.6e-18 66.5 0.1 1.9e-18 66.2 0.1 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF953) Thioredoxin PF00085.20 EXF78602.1 - 0.0034 17.3 0.1 0.0056 16.7 0.1 1.4 1 1 0 1 1 1 1 Thioredoxin Vac7 PF12751.7 EXF78603.1 - 2.2e-156 521.1 4.8 2.2e-156 521.1 4.8 3.0 3 0 0 3 3 3 1 Vacuolar segregation subunit 7 RrnaAD PF00398.20 EXF78604.1 - 5.6e-24 84.6 0.0 6.1e-24 84.5 0.0 1.0 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase RrnaAD PF00398.20 EXF78605.1 - 1.1e-24 87.0 0.0 1.3e-24 86.7 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_25 PF13649.6 EXF78605.1 - 1.8e-06 28.5 0.0 2.7e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 EXF78605.1 - 3.6e-05 23.6 0.0 4.2e-05 23.4 0.0 1.1 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CMAS PF02353.20 EXF78605.1 - 0.00012 21.4 0.0 0.00016 21.0 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_11 PF08241.12 EXF78605.1 - 0.00056 20.5 0.0 0.00081 20.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF78605.1 - 0.00083 20.1 0.0 0.0022 18.7 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EXF78605.1 - 0.002 18.0 0.0 0.0021 17.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EXF78605.1 - 0.0092 15.5 0.0 0.012 15.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_28 PF02636.17 EXF78605.1 - 0.012 15.3 0.0 0.02 14.5 0.0 1.5 1 1 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_4 PF02390.17 EXF78605.1 - 0.015 14.8 0.0 0.023 14.2 0.0 1.2 1 0 0 1 1 1 0 Putative methyltransferase Methyltransf_31 PF13847.6 EXF78605.1 - 0.017 14.9 0.0 0.023 14.5 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Ubie_methyltran PF01209.18 EXF78605.1 - 0.022 14.1 0.0 0.026 13.9 0.0 1.1 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family AAA_lid_4 PF17864.1 EXF78605.1 - 0.031 14.0 0.0 0.058 13.2 0.0 1.3 1 0 0 1 1 1 0 RuvB AAA lid domain Met_10 PF02475.16 EXF78605.1 - 0.036 13.8 0.0 0.04 13.7 0.0 1.1 1 0 0 1 1 1 0 Met-10+ like-protein UPF0020 PF01170.18 EXF78605.1 - 0.074 12.7 0.0 0.6 9.8 0.0 1.9 1 1 1 2 2 2 0 Putative RNA methylase family UPF0020 NodS PF05401.11 EXF78605.1 - 0.084 12.5 0.0 0.1 12.2 0.0 1.1 1 0 0 1 1 1 0 Nodulation protein S (NodS) PRP1_N PF06424.12 EXF78606.1 - 2.7e-52 177.1 9.6 6.6e-52 175.8 9.6 1.7 1 0 0 1 1 1 1 PRP1 splicing factor, N-terminal TPR_14 PF13428.6 EXF78606.1 - 6.5e-29 98.2 35.8 0.00039 21.0 0.2 13.9 4 2 12 16 16 15 9 Tetratricopeptide repeat TPR_19 PF14559.6 EXF78606.1 - 2.1e-27 95.4 15.7 4.2e-07 30.4 0.5 10.1 5 3 4 10 10 10 7 Tetratricopeptide repeat TPR_16 PF13432.6 EXF78606.1 - 1.5e-15 57.6 18.5 1.1e-06 29.1 0.8 7.7 7 2 2 9 9 8 2 Tetratricopeptide repeat TPR_2 PF07719.17 EXF78606.1 - 1.7e-14 52.7 10.9 0.12 12.5 0.0 10.7 11 1 1 12 12 10 2 Tetratricopeptide repeat TPR_8 PF13181.6 EXF78606.1 - 6.7e-13 47.8 3.6 0.012 15.8 0.1 8.4 9 0 0 9 9 8 3 Tetratricopeptide repeat TPR_17 PF13431.6 EXF78606.1 - 1.2e-12 47.2 3.9 0.7 10.4 0.0 9.0 8 1 0 8 8 8 2 Tetratricopeptide repeat NARP1 PF12569.8 EXF78606.1 - 7.2e-09 35.1 10.9 0.21 10.5 0.2 6.0 4 1 2 6 6 6 3 NMDA receptor-regulated protein 1 TPR_15 PF13429.6 EXF78606.1 - 1.6e-08 34.1 23.0 9.5e-05 21.7 6.2 6.5 2 2 3 6 6 6 3 Tetratricopeptide repeat TPR_1 PF00515.28 EXF78606.1 - 1.7e-07 30.7 0.3 0.1 12.5 0.0 5.5 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_9 PF13371.6 EXF78606.1 - 2.7e-07 30.7 8.9 0.00073 19.6 0.0 6.4 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_21 PF09976.9 EXF78606.1 - 4.6e-05 23.2 17.5 0.0082 15.9 1.2 5.2 3 2 2 5 5 5 2 Tetratricopeptide repeat-like domain Suf PF05843.14 EXF78606.1 - 4.7e-05 23.5 0.6 6.9 6.6 0.0 5.1 5 1 1 6 6 6 2 Suppressor of forked protein (Suf) ANAPC3 PF12895.7 EXF78606.1 - 0.00018 21.6 0.3 1.8 8.8 0.0 4.5 3 1 0 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 Wzy_C_2 PF11846.8 EXF78606.1 - 0.00019 21.4 1.6 1 9.2 0.1 4.2 3 1 1 4 4 4 1 Virulence factor membrane-bound polymerase, C-terminal TPR_11 PF13414.6 EXF78606.1 - 0.0012 18.5 10.5 4.9 6.9 0.0 6.2 7 0 0 7 7 7 1 TPR repeat TPR_6 PF13174.6 EXF78606.1 - 0.0069 17.0 12.5 12 6.8 0.1 8.5 10 0 0 10 10 8 0 Tetratricopeptide repeat TPR_7 PF13176.6 EXF78606.1 - 0.028 14.4 1.5 7.5 6.8 0.0 5.0 5 0 0 5 5 5 0 Tetratricopeptide repeat DUF3808 PF10300.9 EXF78606.1 - 0.035 12.9 2.7 9.9 4.8 0.1 4.2 4 1 2 6 6 6 0 Protein of unknown function (DUF3808) CREPT PF16566.5 EXF78606.1 - 0.061 13.5 3.2 2.7 8.1 0.3 2.7 2 0 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour ChAPs PF09295.10 EXF78606.1 - 0.6 9.0 5.5 4.6 6.1 0.3 3.2 2 1 1 3 3 3 0 ChAPs (Chs5p-Arf1p-binding proteins) Apolipoprotein PF01442.18 EXF78607.1 - 0.00076 19.4 0.6 0.00099 19.0 0.6 1.2 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain Mitofilin PF09731.9 EXF78607.1 - 0.017 14.0 3.2 0.019 13.8 3.2 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein MRFAP1 PF15155.6 EXF78607.1 - 2.4 8.7 5.7 4.7 7.8 0.3 2.0 1 1 1 2 2 2 0 MORF4 family-associated protein1 DUF3755 PF12579.8 EXF78608.1 - 0.12 12.0 0.0 0.23 11.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3755) Peroxin-13_N PF04088.13 EXF78608.1 - 0.91 9.8 3.5 0.4 11.0 0.1 2.1 3 0 0 3 3 3 0 Peroxin 13, N-terminal region PPR_2 PF13041.6 EXF78609.1 - 1.3e-05 25.3 2.8 0.1 12.8 0.3 2.9 2 0 0 2 2 2 2 PPR repeat family mRNA_stabil PF13929.6 EXF78609.1 - 0.00028 20.0 0.0 0.00049 19.2 0.0 1.3 1 0 0 1 1 1 1 mRNA stabilisation PPR PF01535.20 EXF78609.1 - 4.8 7.6 4.7 12 6.4 0.6 2.6 2 0 0 2 2 2 0 PPR repeat PP2C PF00481.21 EXF78610.1 - 5.2e-85 285.2 0.0 5.2e-85 285.2 0.0 1.4 2 0 0 2 2 2 1 Protein phosphatase 2C SAPS PF04499.15 EXF78610.1 - 0.15 10.9 0.7 0.18 10.6 0.7 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein He_PIG PF05345.12 EXF78611.1 - 6e-11 42.4 18.2 0.00029 21.0 0.6 5.7 5 1 1 6 6 6 3 Putative Ig domain Cadherin_C_2 PF16492.5 EXF78611.1 - 0.0014 19.4 0.1 0.017 15.9 0.0 2.5 2 0 0 2 2 2 1 Cadherin cytoplasmic C-terminal TMEM154 PF15102.6 EXF78611.1 - 0.0043 17.0 0.7 0.011 15.6 0.1 2.0 2 0 0 2 2 2 1 TMEM154 protein family Herpes_gE PF02480.16 EXF78611.1 - 0.031 13.0 0.0 0.05 12.3 0.0 1.2 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E DUF4448 PF14610.6 EXF78611.1 - 0.046 13.5 0.0 0.092 12.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) EphA2_TM PF14575.6 EXF78611.1 - 0.095 13.6 0.0 0.23 12.3 0.0 1.7 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF5305 PF17231.2 EXF78611.1 - 0.11 11.9 1.7 0.23 10.9 0.0 2.3 3 0 0 3 3 3 0 Family of unknown function (DUF5305) Adeno_E3_CR2 PF02439.15 EXF78611.1 - 0.19 11.5 1.0 0.41 10.5 1.0 1.5 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 MGC-24 PF05283.11 EXF78611.1 - 1.1 9.7 3.2 1.7 9.1 0.1 2.6 2 0 0 2 2 2 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin Methyltransf_16 PF10294.9 EXF78612.1 - 9e-43 146.0 0.0 1.1e-42 145.7 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase Cons_hypoth95 PF03602.15 EXF78612.1 - 0.029 14.0 0.0 0.041 13.5 0.0 1.2 1 0 0 1 1 1 0 Conserved hypothetical protein 95 MTS PF05175.14 EXF78612.1 - 0.049 13.2 0.0 0.078 12.5 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain DPBB_1 PF03330.18 EXF78613.1 - 0.023 14.9 0.1 0.046 14.0 0.1 1.6 1 1 0 1 1 1 0 Lytic transglycolase DAO PF01266.24 EXF78614.1 - 6.3e-39 134.5 4.2 1.3e-38 133.5 4.2 1.5 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EXF78614.1 - 0.0033 17.6 0.1 0.0085 16.3 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain eIF-5_eIF-2B PF01873.17 EXF78615.1 - 1.7e-41 140.8 0.7 2.9e-41 140.0 0.7 1.4 1 0 0 1 1 1 1 Domain found in IF2B/IF5 MYT1 PF08474.11 EXF78615.1 - 0.055 13.4 2.2 0.87 9.5 0.1 2.6 1 1 1 2 2 2 0 Myelin transcription factor 1 DUF3621 PF12285.8 EXF78615.1 - 0.094 13.1 1.1 4.4 7.7 0.1 2.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3621) Arc_trans_TRASH PF08394.10 EXF78615.1 - 0.87 10.0 7.0 1.9 8.9 0.2 2.5 1 1 1 2 2 2 0 Archaeal TRASH domain MARVEL PF01284.23 EXF78617.1 - 7.1e-22 78.0 15.7 8.5e-22 77.7 15.7 1.1 1 0 0 1 1 1 1 Membrane-associating domain DUF1712 PF08217.11 EXF78618.1 - 9.7e-15 54.1 0.0 5.8e-13 48.2 0.0 2.4 2 1 0 2 2 2 2 Fungal domain of unknown function (DUF1712) DNA_pol_E_B PF04042.16 EXF78619.1 - 1.2e-63 214.3 0.0 1.6e-63 213.9 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B Pkinase PF00069.25 EXF78621.1 - 1.7e-69 234.1 0.0 2.4e-69 233.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF78621.1 - 1.4e-32 113.0 0.0 2.3e-32 112.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase AdenylateSensor PF16579.5 EXF78621.1 - 1.9e-18 67.0 0.5 4.9e-10 39.9 0.1 3.1 2 1 0 2 2 2 2 Adenylate sensor of SNF1-like protein kinase UBA_2 PF08587.11 EXF78621.1 - 1.6e-15 56.9 0.2 3.4e-15 55.9 0.2 1.6 1 0 0 1 1 1 1 Ubiquitin associated domain (UBA) Kinase-like PF14531.6 EXF78621.1 - 6.6e-05 22.4 0.0 0.00011 21.7 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EXF78621.1 - 0.0019 17.2 0.1 0.0041 16.1 0.1 1.5 2 0 0 2 2 2 1 Haspin like kinase domain YukC PF10140.9 EXF78621.1 - 0.012 14.5 0.0 0.02 13.7 0.0 1.3 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukC RIO1 PF01163.22 EXF78621.1 - 0.023 14.3 0.1 0.055 13.1 0.1 1.6 1 1 0 1 1 1 0 RIO1 family APH PF01636.23 EXF78621.1 - 0.048 13.6 1.2 0.36 10.7 0.3 2.3 1 1 0 2 2 2 0 Phosphotransferase enzyme family NACHT PF05729.12 EXF78622.1 - 5.8e-08 32.8 0.1 1.9e-07 31.1 0.0 2.0 2 0 0 2 2 2 1 NACHT domain AAA_16 PF13191.6 EXF78622.1 - 0.00021 21.7 0.1 0.0015 18.9 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EXF78622.1 - 0.0011 19.2 0.0 0.007 16.6 0.0 2.4 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 EXF78622.1 - 0.072 13.5 0.0 0.21 12.0 0.0 1.8 1 0 0 1 1 1 0 RNA helicase ABC_tran PF00005.27 EXF78622.1 - 0.086 13.4 1.2 1.8 9.1 0.0 2.6 2 0 0 2 2 2 0 ABC transporter Fib_alpha PF08702.10 EXF78622.1 - 0.1 12.7 4.6 0.04 14.1 1.5 1.9 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Peroxidase_2 PF01328.17 EXF78623.1 - 7.7e-40 137.4 0.0 9.2e-40 137.2 0.0 1.0 1 0 0 1 1 1 1 Peroxidase, family 2 PSII_Pbs27 PF13326.6 EXF78623.1 - 0.028 14.7 0.0 0.035 14.4 0.0 1.3 1 0 0 1 1 1 0 Photosystem II Pbs27 ADH_zinc_N PF00107.26 EXF78623.1 - 0.11 12.4 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Aldo_ket_red PF00248.21 EXF78624.1 - 1.3e-64 218.3 0.0 1.7e-64 217.8 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family adh_short PF00106.25 EXF78625.1 - 2.6e-24 85.7 0.6 6.2e-22 78.0 0.5 2.2 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EXF78625.1 - 1.8e-12 47.3 0.4 3e-11 43.3 0.3 2.1 1 1 1 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF78625.1 - 1.4e-08 34.9 0.3 2.6e-08 34.0 0.3 1.4 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EXF78626.1 - 1.4e-17 64.0 0.1 3.9e-17 62.5 0.1 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 EXF78626.1 - 1.4e-10 40.7 0.1 1.9e-10 40.4 0.1 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_10 PF13460.6 EXF78626.1 - 5e-09 36.3 0.3 1.5e-08 34.8 0.3 1.8 1 1 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 EXF78626.1 - 2.1e-08 34.0 0.0 2.7e-05 23.7 0.0 2.3 2 0 0 2 2 2 2 GDP-mannose 4,6 dehydratase NmrA PF05368.13 EXF78626.1 - 8.1e-08 32.1 0.0 1.8e-07 31.0 0.0 1.5 2 0 0 2 2 2 1 NmrA-like family 3Beta_HSD PF01073.19 EXF78626.1 - 1e-05 24.7 0.0 0.00011 21.4 0.0 2.0 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 EXF78626.1 - 0.0034 16.6 0.0 1.5 7.9 0.0 2.3 1 1 1 2 2 2 2 Male sterility protein Polysacc_synt_2 PF02719.15 EXF78626.1 - 0.0057 15.8 1.4 0.017 14.3 0.2 2.0 2 1 0 2 2 2 1 Polysaccharide biosynthesis protein Sacchrp_dh_NADP PF03435.18 EXF78626.1 - 0.08 13.2 0.0 0.16 12.3 0.0 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain SNAP PF14938.6 EXF78626.1 - 0.098 12.1 0.1 0.14 11.5 0.1 1.1 1 0 0 1 1 1 0 Soluble NSF attachment protein, SNAP MFS_1 PF07690.16 EXF78627.1 - 3.6e-36 124.8 19.5 5.6e-36 124.2 19.5 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily Trp_oprn_chp PF09534.10 EXF78627.1 - 0.073 12.9 0.0 0.15 11.8 0.0 1.5 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) DUF3827 PF12877.7 EXF78627.1 - 0.16 10.3 0.3 0.3 9.4 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) DUF1003 PF06210.11 EXF78627.1 - 0.6 10.2 0.1 0.6 10.2 0.1 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1003) Glyco_hydro_88 PF07470.13 EXF78628.1 - 2.2e-91 306.5 1.2 2.6e-91 306.3 1.2 1.0 1 0 0 1 1 1 1 Glycosyl Hydrolase Family 88 Glyco_hydro_76 PF03663.14 EXF78628.1 - 0.046 13.2 1.3 0.19 11.2 1.4 2.0 1 1 1 2 2 2 0 Glycosyl hydrolase family 76 MFS_1 PF07690.16 EXF78629.1 - 4.6e-38 131.0 11.1 7.7e-38 130.3 11.1 1.4 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF78629.1 - 3.6e-08 32.7 7.7 3.6e-08 32.7 7.7 2.7 2 2 1 3 3 3 1 Sugar (and other) transporter MFS_3 PF05977.13 EXF78629.1 - 3.4e-05 22.5 8.5 0.00061 18.3 3.3 2.3 2 0 0 2 2 2 2 Transmembrane secretion effector MFS_1_like PF12832.7 EXF78629.1 - 3.7 6.3 10.8 13 4.5 5.4 2.4 1 1 1 2 2 2 0 MFS_1 like family Glyco_hydro_3_C PF01915.22 EXF78631.1 - 2.7e-47 161.4 0.0 6e-47 160.2 0.0 1.6 2 0 0 2 2 2 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 EXF78631.1 - 2e-42 145.7 0.0 3.2e-42 145.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 EXF78631.1 - 1.3e-22 79.7 0.2 2.6e-22 78.7 0.2 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain ABC_tran PF00005.27 EXF78632.1 - 1.1e-47 161.9 0.1 7.3e-26 91.3 0.0 4.1 2 2 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 EXF78632.1 - 1.5e-14 54.5 1.7 5.2e-05 23.2 0.9 4.7 3 1 0 3 3 3 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EXF78632.1 - 7.7e-13 48.4 0.1 8.6e-05 22.1 0.0 4.2 2 2 1 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EXF78632.1 - 1.8e-09 38.4 1.0 0.00023 21.8 0.1 3.2 3 0 0 3 3 3 2 AAA domain Chromo PF00385.24 EXF78632.1 - 6.1e-08 32.5 0.7 1.4e-07 31.3 0.7 1.7 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain MMR_HSR1 PF01926.23 EXF78632.1 - 2.2e-07 31.0 0.0 0.0044 17.1 0.0 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EXF78632.1 - 4e-07 30.1 0.0 0.0034 17.3 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase AAA_29 PF13555.6 EXF78632.1 - 4.8e-07 29.4 0.4 0.0088 15.8 0.1 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_28 PF13521.6 EXF78632.1 - 3e-05 24.3 0.0 0.009 16.3 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EXF78632.1 - 4.8e-05 23.7 0.1 0.64 10.3 0.0 3.6 3 0 0 3 3 3 2 AAA domain AAA_18 PF13238.6 EXF78632.1 - 0.0002 21.9 0.0 0.15 12.6 0.0 3.1 2 0 0 2 2 2 1 AAA domain DUF87 PF01935.17 EXF78632.1 - 0.00051 20.2 0.8 0.63 10.1 0.1 3.8 4 0 0 4 4 4 1 Helicase HerA, central domain RNA_helicase PF00910.22 EXF78632.1 - 0.00092 19.6 0.0 2.5 8.5 0.0 2.6 2 0 0 2 2 2 2 RNA helicase NACHT PF05729.12 EXF78632.1 - 0.0011 18.9 0.0 0.84 9.5 0.0 2.8 2 0 0 2 2 2 1 NACHT domain MeaB PF03308.16 EXF78632.1 - 0.0013 17.8 0.4 0.31 10.0 0.1 2.5 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB ALF PF03752.13 EXF78632.1 - 0.0013 18.6 1.6 0.73 9.9 0.2 3.3 3 0 0 3 3 2 1 Short repeats of unknown function CLASP_N PF12348.8 EXF78632.1 - 0.0014 18.3 0.0 0.0059 16.2 0.0 2.1 2 0 0 2 2 2 1 CLASP N terminal AAA_15 PF13175.6 EXF78632.1 - 0.0016 18.2 4.9 0.39 10.4 1.4 3.1 3 1 0 3 3 2 2 AAA ATPase domain Septin PF00735.18 EXF78632.1 - 0.0032 16.8 0.0 0.74 9.0 0.0 2.5 2 0 0 2 2 2 1 Septin AAA_33 PF13671.6 EXF78632.1 - 0.004 17.3 1.2 4.3 7.5 0.0 3.4 3 0 0 3 3 2 1 AAA domain AAA_30 PF13604.6 EXF78632.1 - 0.0042 16.8 0.2 2 8.1 0.1 2.9 2 0 0 2 2 2 1 AAA domain DUF815 PF05673.13 EXF78632.1 - 0.0056 15.9 0.0 1.6 7.8 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_24 PF13479.6 EXF78632.1 - 0.0081 15.9 0.3 0.8 9.4 0.1 2.6 2 0 0 2 2 2 1 AAA domain AAA_13 PF13166.6 EXF78632.1 - 0.0084 14.8 0.4 0.9 8.1 0.0 2.6 3 0 0 3 3 2 1 AAA domain AAA PF00004.29 EXF78632.1 - 0.011 16.1 0.0 5.5 7.4 0.0 3.1 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EXF78632.1 - 0.011 16.1 0.8 4.7 7.6 0.0 3.7 3 1 1 4 4 3 0 AAA ATPase domain PduV-EutP PF10662.9 EXF78632.1 - 0.016 14.9 0.0 0.85 9.4 0.0 2.6 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_14 PF13173.6 EXF78632.1 - 0.017 15.1 0.0 6.5 6.8 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_27 PF13514.6 EXF78632.1 - 0.019 14.6 0.7 7.3 6.1 0.0 3.0 3 0 0 3 3 3 0 AAA domain Dynamin_N PF00350.23 EXF78632.1 - 0.043 13.9 0.0 0.94 9.5 0.0 2.8 2 0 0 2 2 2 0 Dynamin family Roc PF08477.13 EXF78632.1 - 0.056 13.7 0.0 12 6.2 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase TsaE PF02367.17 EXF78632.1 - 0.057 13.4 0.4 19 5.3 0.1 2.7 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NB-ARC PF00931.22 EXF78632.1 - 0.061 12.5 0.1 3.7 6.6 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain CLP1_P PF16575.5 EXF78632.1 - 0.095 12.5 0.4 22 4.8 0.0 3.3 3 0 0 3 3 3 0 mRNA cleavage and polyadenylation factor CLP1 P-loop NTPase_1 PF03266.15 EXF78632.1 - 0.11 12.4 0.3 20 5.0 0.3 3.0 2 0 0 2 2 2 0 NTPase HEAT PF02985.22 EXF78632.1 - 0.13 12.6 1.8 30 5.2 0.1 4.9 5 0 0 5 5 3 0 HEAT repeat SR-25 PF10500.9 EXF78632.1 - 0.14 11.7 4.9 0.29 10.7 4.9 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Glyco_trans_2_3 PF13632.6 EXF78633.1 - 2.3e-52 177.8 2.7 2.3e-52 177.8 2.7 2.1 2 1 1 3 3 3 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.26 EXF78633.1 - 2.8e-06 27.2 0.0 6.8e-06 26.0 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 EXF78633.1 - 0.0033 16.9 0.0 0.0067 15.9 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glyco_hydro_16 PF00722.21 EXF78634.1 - 6.2e-15 55.1 1.4 1e-14 54.4 1.4 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 TaqI_C PF12950.7 EXF78634.1 - 0.097 12.8 0.0 0.22 11.6 0.0 1.5 1 0 0 1 1 1 0 TaqI-like C-terminal specificity domain Fasciclin PF02469.22 EXF78636.1 - 9.6e-45 151.9 0.1 7.6e-28 97.3 0.1 2.2 2 0 0 2 2 2 2 Fasciclin domain RRM_1 PF00076.22 EXF78638.1 - 3.3e-16 58.9 0.0 4.6e-16 58.4 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EXF78638.1 - 0.12 12.4 0.0 0.21 11.7 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif Mem_trans PF03547.18 EXF78639.1 - 2.4e-46 157.9 6.1 2.7e-45 154.4 6.1 1.9 1 1 0 1 1 1 1 Membrane transport protein DUF1634 PF07843.11 EXF78639.1 - 3.1 7.9 6.2 0.56 10.3 0.2 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF1634) Presenilin PF01080.17 EXF78640.1 - 3.9 6.1 5.7 5.8 5.6 5.7 1.2 1 0 0 1 1 1 0 Presenilin Pkinase PF00069.25 EXF78641.1 - 8.5e-54 182.7 0.0 8.1e-51 172.9 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EXF78641.1 - 8.9e-30 103.8 0.0 2e-28 99.4 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase Seadorna_VP7 PF07387.11 EXF78641.1 - 0.00047 19.3 0.1 0.0009 18.4 0.1 1.4 1 0 0 1 1 1 1 Seadornavirus VP7 Kinase-like PF14531.6 EXF78641.1 - 0.00078 18.8 0.0 0.0011 18.3 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EXF78641.1 - 0.038 12.9 0.0 0.055 12.4 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Pkinase_fungal PF17667.1 EXF78641.1 - 0.17 10.7 0.0 0.25 10.1 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase SUR7 PF06687.12 EXF78642.1 - 1.7e-32 112.8 9.3 2.4e-32 112.3 9.3 1.2 1 0 0 1 1 1 1 SUR7/PalI family Trp_oprn_chp PF09534.10 EXF78642.1 - 0.0021 17.9 4.0 0.0021 17.9 4.0 1.6 2 0 0 2 2 2 1 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Amastin PF07344.11 EXF78642.1 - 0.017 15.0 13.1 0.017 15.0 13.1 1.5 2 0 0 2 2 2 0 Amastin surface glycoprotein Clc-like PF07062.12 EXF78642.1 - 1.1 8.7 10.3 0.042 13.3 4.9 1.4 2 0 0 2 2 2 0 Clc-like BPL_LplA_LipB PF03099.19 EXF78643.1 - 0.0013 18.7 0.0 0.0028 17.5 0.0 1.5 1 1 0 1 1 1 1 Biotin/lipoate A/B protein ligase family Phytase PF02333.15 EXF78643.1 - 0.02 13.9 0.0 0.027 13.4 0.0 1.1 1 0 0 1 1 1 0 Phytase DSPc PF00782.20 EXF78644.1 - 1.3e-24 86.5 0.1 4.1e-23 81.7 0.1 2.2 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EXF78644.1 - 0.0043 16.6 0.0 0.0071 15.9 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Init_tRNA_PT PF04179.12 EXF78644.1 - 0.067 13.5 0.0 0.12 12.6 0.0 1.4 1 0 0 1 1 1 0 Rit1 DUSP-like domain UAA PF08449.11 EXF78645.1 - 2e-44 152.0 11.8 2.6e-44 151.7 11.8 1.1 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 EXF78645.1 - 0.0003 21.0 33.5 0.038 14.2 13.8 3.6 3 1 0 3 3 3 3 EamA-like transporter family KH_1 PF00013.29 EXF78646.1 - 4.5e-39 132.1 12.0 5e-16 58.3 0.1 3.2 3 0 0 3 3 3 3 KH domain KH_2 PF07650.17 EXF78646.1 - 1.1e-08 34.8 9.9 0.034 14.0 0.4 3.3 3 0 0 3 3 3 3 KH domain KH_4 PF13083.6 EXF78646.1 - 1.8e-08 34.1 3.3 0.016 15.1 0.2 3.3 3 0 0 3 3 3 3 KH domain KH_5 PF13184.6 EXF78646.1 - 0.0001 22.3 5.6 0.25 11.4 0.1 3.3 3 0 0 3 3 3 2 NusA-like KH domain MOEP19 PF16005.5 EXF78646.1 - 0.078 13.0 0.0 19 5.4 0.0 2.3 2 0 0 2 2 2 0 KH-like RNA-binding domain DEAD PF00270.29 EXF78648.1 - 1.8e-30 106.0 0.0 2.7e-30 105.4 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EXF78648.1 - 2.1e-19 69.9 0.0 1.6e-18 67.1 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EXF78648.1 - 5.8e-06 26.4 0.1 6e-05 23.1 0.1 2.6 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit Dermcidin PF15291.6 EXF78649.1 - 0.0021 18.6 1.1 0.011 16.3 1.1 2.3 1 0 0 1 1 1 1 Dermcidin, antibiotic peptide TIP41 PF04176.13 EXF78650.1 - 5.8e-69 231.0 0.6 7.3e-69 230.7 0.6 1.1 1 0 0 1 1 1 1 TIP41-like family Pkinase PF00069.25 EXF78652.1 - 3e-71 239.9 0.0 3.8e-71 239.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF78652.1 - 1.1e-43 149.5 0.0 1.5e-43 149.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EXF78652.1 - 9.9e-07 28.3 0.0 4e-06 26.4 0.0 1.9 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 EXF78652.1 - 0.00064 19.1 0.1 0.001 18.4 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 EXF78652.1 - 0.016 14.8 0.0 0.084 12.5 0.0 1.9 1 1 1 2 2 2 0 RIO1 family FTA2 PF13095.6 EXF78652.1 - 0.061 12.9 0.0 0.19 11.3 0.0 1.7 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 YrbL-PhoP_reg PF10707.9 EXF78652.1 - 0.085 12.4 0.1 0.24 10.9 0.1 1.8 1 1 0 1 1 1 0 PhoP regulatory network protein YrbL Haspin_kinase PF12330.8 EXF78652.1 - 0.13 11.1 8.7 5.1 5.9 8.8 2.1 1 1 0 1 1 1 0 Haspin like kinase domain Pkinase_fungal PF17667.1 EXF78652.1 - 0.41 9.4 2.3 0.61 8.8 2.3 1.4 1 1 0 1 1 1 0 Fungal protein kinase Peptidase_M76 PF09768.9 EXF78653.1 - 1.2e-61 207.5 3.8 7.6e-61 204.8 3.8 1.9 1 1 0 1 1 1 1 Peptidase M76 family SprT-like PF10263.9 EXF78653.1 - 0.026 14.4 0.6 0.092 12.6 0.1 2.0 2 0 0 2 2 2 0 SprT-like family Peptidase_M91 PF14891.6 EXF78653.1 - 0.066 13.5 0.1 0.13 12.6 0.1 1.5 1 0 0 1 1 1 0 Effector protein AA_kinase PF00696.28 EXF78654.1 - 2.5e-39 135.3 1.5 3.6e-39 134.8 1.5 1.2 1 0 0 1 1 1 1 Amino acid kinase family PUA PF01472.20 EXF78654.1 - 1e-14 54.2 0.2 6.9e-14 51.6 0.0 2.3 2 0 0 2 2 2 1 PUA domain CLTH PF10607.9 EXF78655.1 - 1.1e-37 129.3 0.0 1.7e-37 128.5 0.0 1.4 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.11 EXF78655.1 - 0.00075 19.4 0.2 0.0026 17.6 0.0 2.0 2 0 0 2 2 2 1 LisH DUF2795 PF11387.8 EXF78655.1 - 0.021 15.0 0.0 1.7 8.9 0.0 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2795) HLH PF00010.26 EXF78656.1 - 4e-12 45.9 1.3 7.6e-12 45.0 1.3 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain AAA_28 PF13521.6 EXF78656.1 - 0.11 12.8 0.5 0.37 11.0 0.0 2.1 2 0 0 2 2 2 0 AAA domain DUF5559 PF17714.1 EXF78656.1 - 0.13 12.1 3.4 0.24 11.2 3.4 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5559) DivIC PF04977.15 EXF78656.1 - 0.29 10.9 2.6 0.65 9.8 2.6 1.6 1 0 0 1 1 1 0 Septum formation initiator GIT1_C PF12205.8 EXF78656.1 - 0.37 10.9 6.2 0.58 10.3 2.9 2.6 2 1 0 2 2 2 0 G protein-coupled receptor kinase-interacting protein 1 C term DUF2841 PF11001.8 EXF78657.1 - 1.8e-43 147.5 6.9 3e-43 146.8 6.9 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2841) GRP PF07172.11 EXF78657.1 - 3 8.6 7.5 8 7.2 7.5 1.7 1 0 0 1 1 1 0 Glycine rich protein family ABC_membrane PF00664.23 EXF78658.1 - 9.5e-94 314.1 23.0 3.3e-48 164.7 6.1 2.3 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EXF78658.1 - 1.6e-50 171.1 0.0 9.6e-31 107.1 0.1 2.8 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EXF78658.1 - 1.7e-09 37.5 4.3 0.0056 16.1 0.1 4.3 2 2 0 4 4 4 3 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 EXF78658.1 - 1.4e-06 28.4 0.1 0.06 13.4 0.0 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EXF78658.1 - 8.3e-05 22.6 0.2 0.099 12.5 0.0 2.8 3 0 0 3 3 3 2 RsgA GTPase UPF0093 PF03653.13 EXF78658.1 - 0.0014 18.9 1.3 0.0041 17.3 0.3 2.4 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0093) Dynamin_N PF00350.23 EXF78658.1 - 0.0018 18.3 3.2 0.068 13.2 0.0 3.0 3 0 0 3 3 3 1 Dynamin family AAA_16 PF13191.6 EXF78658.1 - 0.0024 18.3 1.9 0.067 13.6 0.1 2.8 3 0 0 3 3 2 1 AAA ATPase domain AAA_29 PF13555.6 EXF78658.1 - 0.0068 16.1 0.3 2.8 7.7 0.0 2.7 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_23 PF13476.6 EXF78658.1 - 0.022 15.3 1.1 3.9 7.9 0.0 3.3 4 0 0 4 4 4 0 AAA domain ABC_membrane_2 PF06472.15 EXF78658.1 - 0.032 13.6 0.1 0.032 13.6 0.1 2.3 2 0 0 2 2 2 0 ABC transporter transmembrane region 2 AAA_21 PF13304.6 EXF78658.1 - 0.048 13.5 0.4 8.8 6.0 0.0 2.8 2 1 1 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 EXF78658.1 - 0.09 12.5 0.3 2.7 7.6 0.0 2.5 2 0 0 2 2 2 0 AAA ATPase domain DUF87 PF01935.17 EXF78658.1 - 0.095 12.8 2.8 1.1 9.3 0.1 2.7 3 0 0 3 3 2 0 Helicase HerA, central domain IstB_IS21 PF01695.17 EXF78658.1 - 0.12 12.1 0.0 2.4 7.9 0.0 2.5 2 0 0 2 2 2 0 IstB-like ATP binding protein AIG1 PF04548.16 EXF78658.1 - 0.24 10.7 0.8 5.6 6.2 0.0 2.4 2 0 0 2 2 2 0 AIG1 family AAA_30 PF13604.6 EXF78658.1 - 0.27 10.9 3.0 1.7 8.3 0.0 2.9 2 1 0 2 2 2 0 AAA domain AAA_22 PF13401.6 EXF78658.1 - 0.5 10.6 2.3 59 3.9 0.6 3.4 2 1 0 2 2 2 0 AAA domain MWFE PF15879.5 EXF78658.1 - 1.4 9.1 3.8 1.3 9.3 0.4 2.9 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase MWFE subunit SH3_16 PF18348.1 EXF78660.1 - 0.08 12.8 0.5 0.35 10.7 0.6 1.9 2 0 0 2 2 2 0 Bacterial dipeptidyl-peptidase Sh3 domain GREB1 PF15782.5 EXF78661.1 - 3.5 4.6 5.7 3.9 4.5 5.7 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer CRIM PF16978.5 EXF78662.1 - 2.5e-46 157.3 0.0 1.1e-45 155.2 0.0 2.0 2 0 0 2 2 2 1 SAPK-interacting protein 1 (Sin1), middle CRIM domain SIN1_PH PF16979.5 EXF78662.1 - 1.2e-24 86.7 1.2 2.5e-24 85.6 1.2 1.6 1 0 0 1 1 1 1 SAPK-interacting protein 1 (Sin1), Pleckstrin-homology PH PF00169.29 EXF78662.1 - 0.012 16.2 0.1 0.023 15.2 0.1 1.5 1 0 0 1 1 1 0 PH domain TUG-UBL1 PF11470.8 EXF78662.1 - 0.012 15.8 0.0 0.028 14.6 0.0 1.5 1 0 0 1 1 1 0 TUG ubiquitin-like domain PBP1_TM PF14812.6 EXF78662.1 - 1.4 9.4 11.6 0.2 12.1 2.4 3.3 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal PRCC PF10253.9 EXF78663.1 - 7.3e-38 131.5 11.3 7.3e-38 131.5 11.3 2.4 1 1 0 2 2 2 1 Mitotic checkpoint regulator, MAD2B-interacting HLH PF00010.26 EXF78664.1 - 0.11 12.4 0.0 0.29 11.1 0.0 1.6 1 0 0 1 1 1 0 Helix-loop-helix DNA-binding domain DUF3517 PF12030.8 EXF78665.1 - 2.2e-96 322.7 4.0 4.9e-96 321.6 4.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3517) UCH PF00443.29 EXF78665.1 - 4.6e-39 134.5 0.0 1.2e-38 133.1 0.0 1.8 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EXF78665.1 - 1.1e-19 71.2 0.0 2.6e-19 70.0 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Pox_A3L PF05288.11 EXF78665.1 - 0.0039 17.1 0.0 0.02 14.9 0.0 2.3 1 0 0 1 1 1 1 Poxvirus A3L Protein RNase_P_pop3 PF08228.11 EXF78666.1 - 6.9e-08 32.7 0.0 1.3e-05 25.3 0.0 2.2 2 0 0 2 2 2 2 RNase P subunit Pop3 Hemolysin_N PF12563.8 EXF78666.1 - 0.092 12.3 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 Hemolytic toxin N terminal NOC3p PF07540.11 EXF78668.1 - 1.9e-29 102.0 0.5 2.7e-28 98.3 0.2 2.8 2 0 0 2 2 2 1 Nucleolar complex-associated protein CBF PF03914.17 EXF78668.1 - 7.3e-25 88.0 2.8 9e-25 87.7 0.6 2.2 2 0 0 2 2 2 1 CBF/Mak21 family CENP-B_dimeris PF09026.10 EXF78668.1 - 0.015 15.7 5.0 0.015 15.7 5.0 3.0 3 0 0 3 3 3 0 Centromere protein B dimerisation domain UPF0113_N PF17833.1 EXF78669.1 - 5e-26 91.1 0.0 6.8e-26 90.7 0.0 1.2 1 0 0 1 1 1 1 UPF0113 Pre-PUA domain UPF0113 PF03657.13 EXF78669.1 - 3.9e-24 84.7 0.0 2.2e-23 82.3 0.0 2.0 2 0 0 2 2 2 1 UPF0113 PUA domain Glyco_trans_2_3 PF13632.6 EXF78670.1 - 1.6e-49 168.5 5.6 4.8e-49 167.0 5.6 1.8 1 0 0 1 1 1 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.26 EXF78670.1 - 1.1e-05 25.3 0.0 3.5e-05 23.7 0.0 1.8 2 0 0 2 2 2 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 EXF78670.1 - 0.00029 20.3 0.0 0.00055 19.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glyco_tranf_2_3 PF13641.6 EXF78670.1 - 0.0049 16.8 0.1 0.0087 16.0 0.1 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Pro-kuma_activ PF09286.11 EXF78672.1 - 7.2e-38 130.1 0.1 1.6e-37 129.0 0.1 1.6 1 0 0 1 1 1 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 EXF78672.1 - 0.00015 21.1 0.1 0.00025 20.4 0.1 1.2 1 0 0 1 1 1 1 Subtilase family BBP1_C PF15272.6 EXF78674.1 - 0.034 14.0 0.4 0.034 14.0 0.4 1.9 2 0 0 2 2 2 0 Spindle pole body component BBP1, C-terminal U3_snoRNA_assoc PF08297.11 EXF78674.1 - 9.8 7.0 7.1 0.67 10.7 0.2 2.8 3 0 0 3 3 3 0 U3 snoRNA associated DUF2043 PF09740.9 EXF78675.1 - 0.11 13.2 0.4 0.14 12.9 0.4 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2043) Ribosomal_S14 PF00253.21 EXF78675.1 - 0.12 12.2 1.2 1.3 8.8 0.3 2.3 1 1 1 2 2 2 0 Ribosomal protein S14p/S29e Antifungal_prot PF11402.8 EXF78675.1 - 0.17 12.1 4.1 0.48 10.7 4.1 1.6 1 1 0 1 1 1 0 Antifungal protein Methyltransf_31 PF13847.6 EXF78676.1 - 2.8e-16 59.7 0.0 1.5e-14 54.0 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF78676.1 - 2.7e-09 37.6 0.0 9.4e-08 32.7 0.1 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EXF78676.1 - 1.1e-08 35.1 0.1 3.5e-08 33.5 0.1 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF78676.1 - 2.1e-08 34.8 0.0 7e-08 33.1 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF78676.1 - 1.7e-07 31.8 0.6 9.7e-06 26.2 0.0 2.5 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_32 PF13679.6 EXF78676.1 - 1.2e-06 28.6 0.0 1.4e-06 28.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain AdoMet_MTase PF07757.13 EXF78676.1 - 0.00029 21.1 0.0 0.00052 20.3 0.0 1.4 1 0 0 1 1 1 1 Predicted AdoMet-dependent methyltransferase MTS PF05175.14 EXF78676.1 - 0.00038 20.0 0.0 0.00058 19.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain MetW PF07021.12 EXF78676.1 - 0.0053 16.4 0.0 0.0091 15.6 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW PrmA PF06325.13 EXF78676.1 - 0.0087 15.5 0.0 0.012 15.1 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_18 PF12847.7 EXF78676.1 - 0.19 11.7 0.0 0.5 10.3 0.0 1.6 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_4 PF02390.17 EXF78676.1 - 0.23 10.9 0.0 0.35 10.3 0.0 1.2 1 0 0 1 1 1 0 Putative methyltransferase HEAT PF02985.22 EXF78677.1 - 2.4e-40 133.1 14.6 0.015 15.5 0.1 13.2 14 0 0 14 14 14 10 HEAT repeat HEAT_2 PF13646.6 EXF78677.1 - 5e-35 119.8 5.6 3.2e-11 43.5 0.0 8.2 4 2 4 8 8 8 8 HEAT repeats HEAT_EZ PF13513.6 EXF78677.1 - 1.1e-12 48.2 4.2 0.016 15.7 0.1 7.7 8 1 1 9 9 8 2 HEAT-like repeat Cnd1 PF12717.7 EXF78677.1 - 6.5e-12 45.8 11.5 0.00011 22.3 0.1 6.3 5 1 1 7 7 7 4 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 EXF78677.1 - 2.4e-11 44.1 5.0 0.049 14.2 0.1 7.9 5 1 4 9 9 9 2 Vacuolar 14 Fab1-binding region Adaptin_N PF01602.20 EXF78677.1 - 8.7e-07 27.9 10.6 0.0015 17.2 0.1 5.2 2 1 1 6 6 6 3 Adaptin N terminal region RTP1_C1 PF10363.9 EXF78677.1 - 2e-06 28.0 5.3 0.18 12.0 0.1 5.3 4 1 1 5 5 5 2 Required for nuclear transport of RNA pol II C-terminus 1 CLASP_N PF12348.8 EXF78677.1 - 0.00019 21.1 2.9 1.3 8.5 0.1 4.6 2 2 3 5 5 5 1 CLASP N terminal M11L PF11099.8 EXF78677.1 - 0.011 16.0 0.4 3.7 7.8 0.0 3.4 2 1 0 3 3 3 0 Apoptosis regulator M11L like Ecm29 PF13001.7 EXF78677.1 - 0.014 14.2 3.8 0.21 10.2 0.0 3.5 3 1 0 4 4 4 0 Proteasome stabiliser Proteasom_PSMB PF10508.9 EXF78677.1 - 0.027 13.0 5.9 0.34 9.3 0.1 2.5 2 1 0 2 2 2 0 Proteasome non-ATPase 26S subunit Arm PF00514.23 EXF78677.1 - 0.32 11.1 4.2 29 4.9 0.0 4.8 6 0 0 6 6 6 0 Armadillo/beta-catenin-like repeat API5 PF05918.11 EXF78677.1 - 8 5.1 8.5 1.1 8.0 0.4 3.4 4 1 0 5 5 5 0 Apoptosis inhibitory protein 5 (API5) tRNA_synthFbeta PF17759.1 EXF78678.1 - 8.3e-46 156.1 0.0 1.3e-45 155.5 0.0 1.3 1 0 0 1 1 1 1 Phenylalanyl tRNA synthetase beta chain CLM domain PhetRS_B1 PF18262.1 EXF78678.1 - 2.6e-31 107.7 0.8 1.8e-30 105.0 0.1 2.5 2 1 0 2 2 2 1 Phe-tRNA synthetase beta subunit B1 domain B3_4 PF03483.17 EXF78678.1 - 7.1e-27 94.2 0.1 1.2e-26 93.5 0.1 1.4 1 0 0 1 1 1 1 B3/4 domain B5 PF03484.15 EXF78678.1 - 4.6e-16 58.9 0.0 2.4e-13 50.2 0.0 2.6 2 0 0 2 2 2 2 tRNA synthetase B5 domain Myotub-related PF06602.14 EXF78680.1 - 3.9e-147 489.8 0.1 4.9e-147 489.5 0.1 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Y_phosphatase PF00102.27 EXF78680.1 - 0.0074 15.9 0.0 0.013 15.1 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 EXF78680.1 - 0.13 12.2 0.0 0.24 11.3 0.0 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family Ribosomal_S3_C PF00189.20 EXF78681.1 - 8.5e-25 87.1 0.2 4.4e-24 84.8 0.1 2.1 2 0 0 2 2 2 1 Ribosomal protein S3, C-terminal domain KH_2 PF07650.17 EXF78681.1 - 6.6e-12 45.1 0.1 1.1e-11 44.4 0.1 1.4 1 0 0 1 1 1 1 KH domain Coilin_N PF15862.5 EXF78681.1 - 0.089 12.6 1.0 0.33 10.8 0.0 2.0 2 0 0 2 2 2 0 Coilin N-terminus UN_NPL4 PF11543.8 EXF78681.1 - 0.1 13.1 0.0 0.2 12.2 0.0 1.5 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 Mg_trans_NIPA PF05653.14 EXF78682.1 - 2.3e-100 335.5 14.8 2.7e-100 335.3 14.8 1.0 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 EXF78682.1 - 0.00014 22.1 6.2 0.00014 22.1 6.2 3.3 3 0 0 3 3 3 2 EamA-like transporter family DUF2420 PF10336.9 EXF78683.1 - 9.6e-11 41.7 0.0 2e-10 40.7 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2420) Adap_comp_sub PF00928.21 EXF78684.1 - 1.7e-17 63.7 0.1 2.5e-17 63.1 0.1 1.2 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 EXF78684.1 - 3.5e-08 33.5 0.1 5.9e-08 32.8 0.1 1.4 1 0 0 1 1 1 1 Clathrin adaptor complex small chain BBP2_2 PF10082.9 EXF78684.1 - 0.00053 18.9 0.1 0.00084 18.3 0.1 1.2 1 0 0 1 1 1 1 Putative beta-barrel porin 2 RPM2 PF08579.11 EXF78684.1 - 0.0075 16.7 0.3 0.015 15.7 0.3 1.5 1 0 0 1 1 1 1 Mitochondrial ribonuclease P subunit (RPM2) ANAPC4 PF12896.7 EXF78685.1 - 9.3e-61 204.9 0.0 1.5e-60 204.2 0.0 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 4 ANAPC4_WD40 PF12894.7 EXF78685.1 - 1.7e-10 41.0 0.0 9.7e-10 38.6 0.0 2.3 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EXF78685.1 - 0.029 15.2 0.0 0.49 11.3 0.0 3.1 2 0 0 2 2 2 0 WD domain, G-beta repeat Gtr1_RagA PF04670.12 EXF78686.1 - 2.2e-70 236.7 0.1 2.6e-70 236.4 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Roc PF08477.13 EXF78686.1 - 0.014 15.6 0.0 0.031 14.5 0.0 1.7 1 1 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 EXF78686.1 - 0.017 14.7 0.0 0.028 14.0 0.0 1.3 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 EXF78686.1 - 0.026 14.9 0.0 0.066 13.6 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain MMR_HSR1 PF01926.23 EXF78686.1 - 0.089 12.9 0.0 0.17 12.0 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase MIF PF01187.18 EXF78687.1 - 6e-10 39.4 0.0 1.1e-09 38.5 0.0 1.5 1 0 0 1 1 1 1 Macrophage migration inhibitory factor (MIF) Voltage_CLC PF00654.20 EXF78690.1 - 1.1e-86 291.3 27.6 1.1e-86 291.3 27.6 1.4 2 0 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.28 EXF78690.1 - 0.00047 20.5 0.0 0.019 15.4 0.0 2.6 2 0 0 2 2 2 1 CBS domain LacI PF00356.21 EXF78690.1 - 0.38 10.6 1.8 1 9.2 1.8 1.6 1 0 0 1 1 1 0 Bacterial regulatory proteins, lacI family Neurochondrin PF05536.11 EXF78691.1 - 5.3e-89 299.2 0.1 6.4e-89 298.9 0.1 1.0 1 0 0 1 1 1 1 Neurochondrin INTS5_C PF14838.6 EXF78691.1 - 0.018 13.7 0.0 0.068 11.8 0.0 1.8 2 0 0 2 2 2 0 Integrator complex subunit 5 C-terminus CDC45 PF02724.14 EXF78692.1 - 0.025 12.9 9.0 0.03 12.6 9.0 1.2 1 0 0 1 1 1 0 CDC45-like protein YqzE PF14038.6 EXF78692.1 - 0.027 14.5 2.0 0.027 14.5 2.0 2.8 2 1 1 3 3 3 0 YqzE-like protein NPR3 PF03666.13 EXF78692.1 - 0.065 12.0 2.5 0.09 11.6 2.5 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 ATP11 PF06644.11 EXF78692.1 - 0.068 13.0 4.3 0.11 12.3 4.3 1.4 1 0 0 1 1 1 0 ATP11 protein DDHD PF02862.17 EXF78692.1 - 0.22 11.7 0.9 0.24 11.5 0.9 1.3 1 0 0 1 1 1 0 DDHD domain SAPS PF04499.15 EXF78692.1 - 0.41 9.4 3.3 0.39 9.4 3.3 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Coilin_N PF15862.5 EXF78692.1 - 0.46 10.3 16.0 0.029 14.2 10.3 1.8 2 0 0 2 2 2 0 Coilin N-terminus DUF913 PF06025.12 EXF78692.1 - 0.7 8.8 3.1 0.78 8.6 3.1 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Hid1 PF12722.7 EXF78692.1 - 1 7.4 2.8 1.1 7.4 2.8 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein RNA_pol_Rpc4 PF05132.14 EXF78692.1 - 1.1 9.6 10.2 0.16 12.4 5.6 1.8 2 0 0 2 2 2 0 RNA polymerase III RPC4 PBP1_TM PF14812.6 EXF78692.1 - 1.3 9.4 9.1 0.082 13.3 2.8 2.2 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Ras PF00071.22 EXF78693.1 - 1.3e-52 177.7 0.0 1.5e-52 177.5 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EXF78693.1 - 5.4e-19 68.6 0.0 7.4e-19 68.1 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EXF78693.1 - 1.3e-06 28.0 0.0 1.7e-06 27.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Arginase PF00491.21 EXF78694.1 - 5.4e-93 311.5 0.0 6.9e-93 311.2 0.0 1.0 1 0 0 1 1 1 1 Arginase family UPF0489 PF12640.7 EXF78694.1 - 0.014 15.6 0.8 0.042 14.1 0.2 1.9 1 1 1 2 2 2 0 UPF0489 domain tRNA-synt_2 PF00152.20 EXF78695.1 - 2.2e-84 283.2 0.0 3.5e-84 282.6 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EXF78695.1 - 1.3e-10 41.1 0.0 2.5e-10 40.2 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA_anti_2 PF13742.6 EXF78695.1 - 0.022 14.9 0.0 0.053 13.7 0.0 1.6 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain SPOUT_MTase PF02590.17 EXF78695.1 - 0.03 14.3 1.0 0.063 13.2 1.0 1.5 1 0 0 1 1 1 0 Predicted SPOUT methyltransferase RRM_1 PF00076.22 EXF78696.1 - 3.1e-36 123.0 0.1 4.6e-11 42.4 0.2 4.4 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EXF78696.1 - 2.9e-14 52.7 0.0 0.0092 15.8 0.0 4.3 4 0 0 4 4 4 4 Occluded RNA-recognition motif RRM PF10378.9 EXF78696.1 - 6.1e-09 35.5 6.6 6.1e-09 35.5 6.6 3.9 5 0 0 5 5 5 1 Putative RRM domain DUF4523 PF15023.6 EXF78696.1 - 1.6e-06 28.1 0.0 0.0086 15.9 0.0 3.4 3 0 0 3 3 3 2 Protein of unknown function (DUF4523) RRM_7 PF16367.5 EXF78696.1 - 2.7e-06 27.4 0.0 0.027 14.6 0.0 3.9 4 0 0 4 4 4 2 RNA recognition motif RRM_3 PF08777.11 EXF78696.1 - 0.015 15.3 0.2 0.28 11.2 0.1 2.7 3 0 0 3 3 3 0 RNA binding motif RNA_bind PF08675.11 EXF78696.1 - 0.05 13.6 0.7 0.2 11.7 0.0 2.3 3 0 0 3 3 3 0 RNA binding domain Nup35_RRM_2 PF14605.6 EXF78696.1 - 0.061 13.3 0.0 25 5.0 0.0 3.3 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif zf-C2H2 PF00096.26 EXF78697.1 - 4.6e-30 102.4 48.0 5.8e-05 23.3 0.7 10.4 10 0 0 10 10 10 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EXF78697.1 - 1.1e-20 72.6 50.7 0.046 14.6 0.5 10.9 10 1 0 10 10 10 8 C2H2-type zinc finger FOXP-CC PF16159.5 EXF78697.1 - 2.7e-12 47.1 25.1 0.096 13.3 0.7 7.6 4 1 4 8 8 8 5 FOXP coiled-coil domain zf-H2C2_2 PF13465.6 EXF78697.1 - 5.3e-12 45.6 45.2 0.0025 18.1 1.3 10.7 11 0 0 11 11 11 4 Zinc-finger double domain zf-C2H2_jaz PF12171.8 EXF78697.1 - 2.1e-07 31.1 27.6 0.43 10.9 0.0 9.8 11 0 0 11 11 11 3 Zinc-finger double-stranded RNA-binding zf-C2H2_8 PF15909.5 EXF78697.1 - 6.2e-06 26.4 13.6 0.24 11.7 5.6 4.8 3 1 2 5 5 5 3 C2H2-type zinc ribbon zf-C2H2_aberr PF17017.5 EXF78697.1 - 0.00011 22.4 16.7 5 7.2 5.1 5.7 3 1 1 5 5 5 3 Aberrant zinc-finger Ogr_Delta PF04606.12 EXF78697.1 - 0.00025 20.9 2.8 0.51 10.4 0.2 4.4 3 1 1 4 4 4 1 Ogr/Delta-like zinc finger DUF4187 PF13821.6 EXF78697.1 - 0.0036 17.0 1.6 0.029 14.1 0.3 2.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4187) zf-met PF12874.7 EXF78697.1 - 0.0084 16.5 20.4 0.072 13.5 0.0 8.0 9 0 0 9 9 9 1 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 EXF78697.1 - 1.1 9.3 0.0 1.1 9.3 0.0 5.0 5 0 0 5 5 5 0 C2H2-type zinc finger zf_Hakai PF18408.1 EXF78697.1 - 8.8 6.1 30.8 20 5.0 0.2 9.0 10 0 0 10 10 10 0 C2H2 Hakai zinc finger domain RNA_pol_Rpb6 PF01192.22 EXF78698.1 - 4e-17 61.9 0.2 6.7e-17 61.2 0.2 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb6 Tyrosinase PF00264.20 EXF78699.1 - 1.5e-47 162.8 0.2 1.5e-47 162.8 0.2 1.5 2 0 0 2 2 2 1 Common central domain of tyrosinase Med10 PF09748.9 EXF78700.1 - 4.5e-47 159.0 0.0 5.2e-47 158.8 0.0 1.0 1 0 0 1 1 1 1 Transcription factor subunit Med10 of Mediator complex DUF3877 PF12993.7 EXF78700.1 - 0.023 14.6 0.0 0.063 13.1 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function, E. rectale Gene description (DUF3877) TPR_1 PF00515.28 EXF78701.1 - 4.6e-37 124.3 17.2 1.1e-06 28.2 0.2 8.3 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_2 PF07719.17 EXF78701.1 - 4.3e-35 117.0 15.7 3.6e-06 26.7 0.0 8.2 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_11 PF13414.6 EXF78701.1 - 5.2e-29 99.7 16.1 6.8e-09 35.3 0.3 7.2 6 1 1 7 7 7 6 TPR repeat DnaJ PF00226.31 EXF78701.1 - 1.6e-27 95.4 6.3 5.3e-27 93.7 4.0 2.5 2 0 0 2 2 2 1 DnaJ domain TPR_16 PF13432.6 EXF78701.1 - 6.6e-21 74.7 2.3 0.00019 22.0 0.1 6.2 5 1 0 5 5 5 5 Tetratricopeptide repeat TPR_19 PF14559.6 EXF78701.1 - 1.1e-20 73.8 10.9 1.3e-05 25.6 0.0 6.0 3 2 2 5 5 5 4 Tetratricopeptide repeat ANAPC3 PF12895.7 EXF78701.1 - 9.8e-15 54.6 5.6 1.7e-06 28.1 0.2 3.6 3 0 0 3 3 3 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 EXF78701.1 - 1.5e-14 52.9 15.9 0.00091 19.3 0.5 7.8 9 0 0 9 9 7 4 Tetratricopeptide repeat TPR_14 PF13428.6 EXF78701.1 - 2.4e-14 52.8 9.2 0.00019 22.0 0.0 7.4 5 1 2 7 7 6 2 Tetratricopeptide repeat TPR_17 PF13431.6 EXF78701.1 - 2.9e-14 52.3 11.4 0.0037 17.5 0.0 7.2 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_12 PF13424.6 EXF78701.1 - 6.9e-13 48.7 12.4 0.045 14.0 0.2 6.5 4 2 2 6 6 6 3 Tetratricopeptide repeat TPR_9 PF13371.6 EXF78701.1 - 7.2e-12 45.3 6.1 0.02 15.0 0.1 5.1 4 1 1 5 5 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 EXF78701.1 - 8.2e-11 41.1 6.0 0.37 10.9 0.0 7.5 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_6 PF13174.6 EXF78701.1 - 1.3e-06 28.6 16.9 0.087 13.5 0.0 8.3 8 2 1 9 9 7 1 Tetratricopeptide repeat TPR_10 PF13374.6 EXF78701.1 - 3.8e-05 23.4 9.0 0.28 11.1 0.0 5.5 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_15 PF13429.6 EXF78701.1 - 0.00017 20.9 9.1 0.24 10.6 0.0 4.4 2 2 2 4 4 4 2 Tetratricopeptide repeat NARP1 PF12569.8 EXF78701.1 - 0.00048 19.2 4.6 0.0017 17.4 0.7 2.9 2 1 1 3 3 3 1 NMDA receptor-regulated protein 1 TPR_4 PF07721.14 EXF78701.1 - 0.0011 19.4 1.4 0.13 13.0 0.0 4.2 4 0 0 4 4 3 1 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.6 EXF78701.1 - 0.007 16.8 6.1 7.9 6.9 1.0 4.3 3 1 1 4 4 3 0 Alkyl sulfatase dimerisation ChAPs PF09295.10 EXF78701.1 - 0.015 14.3 0.0 0.028 13.4 0.0 1.4 1 0 0 1 1 1 0 ChAPs (Chs5p-Arf1p-binding proteins) TPR_20 PF14561.6 EXF78701.1 - 0.027 14.8 8.8 5.2 7.5 0.0 5.1 3 3 2 5 5 5 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EXF78701.1 - 0.037 14.1 3.7 4.6 7.4 0.0 4.2 4 0 0 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat PPR PF01535.20 EXF78701.1 - 0.049 13.9 0.2 20 5.7 0.0 3.6 4 0 0 4 4 2 0 PPR repeat DUF928 PF06051.12 EXF78701.1 - 0.051 13.4 0.4 0.12 12.2 0.4 1.6 1 0 0 1 1 1 0 Domain of Unknown Function (DUF928) Coatomer_E PF04733.14 EXF78701.1 - 0.055 12.9 0.6 7 6.0 0.0 2.5 2 0 0 2 2 2 0 Coatomer epsilon subunit BTAD PF03704.17 EXF78701.1 - 0.075 13.5 8.0 17 5.8 0.1 4.9 3 2 2 5 5 4 0 Bacterial transcriptional activator domain RPT PF13446.6 EXF78701.1 - 0.12 12.3 0.1 0.77 9.7 0.0 2.4 2 0 0 2 2 1 0 A repeated domain in UCH-protein DUF357 PF04010.13 EXF78701.1 - 2.6 8.2 4.8 2.9 8.0 0.2 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF357) EF-hand_6 PF13405.6 EXF78702.1 - 4.2e-12 45.0 0.3 1.3e-05 24.8 0.1 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 EXF78702.1 - 2.9e-10 38.9 1.4 0.00042 19.7 0.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 EXF78702.1 - 1.5e-07 31.8 0.0 0.018 15.5 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 EXF78702.1 - 4.1e-06 26.6 0.4 0.0069 16.2 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 EXF78702.1 - 4.1e-06 26.0 3.9 0.0065 15.9 0.4 2.4 2 0 0 2 2 2 2 EF hand EF-hand_9 PF14658.6 EXF78702.1 - 0.00049 20.4 0.0 0.63 10.4 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain ORC6 PF05460.13 EXF78702.1 - 0.99 8.6 5.1 1.8 7.7 5.1 1.4 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Afi1 PF07792.12 EXF78703.1 - 1.9e-47 161.1 0.3 3.1e-47 160.4 0.3 1.4 1 0 0 1 1 1 1 Docking domain of Afi1 for Arf3 in vesicle trafficking SPA PF08616.10 EXF78703.1 - 6.6e-36 122.7 0.0 1.2e-35 121.9 0.0 1.4 1 0 0 1 1 1 1 Stabilization of polarity axis Avl9 PF09794.9 EXF78703.1 - 7.8e-08 31.4 0.0 0.013 14.2 0.0 3.9 3 1 1 4 4 4 2 Transport protein Avl9 Cwf_Cwc_15 PF04889.12 EXF78703.1 - 0.028 14.2 6.5 0.052 13.3 6.5 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DUF2347 PF09804.9 EXF78703.1 - 0.034 13.7 0.0 0.12 11.9 0.0 2.0 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) Astro_capsid_p PF12226.8 EXF78703.1 - 0.21 10.7 3.1 0.34 10.0 3.1 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein QWRF PF04484.12 EXF78703.1 - 2.7 7.6 5.0 4.2 7.0 5.0 1.2 1 0 0 1 1 1 0 QWRF family SOG2 PF10428.9 EXF78703.1 - 3.2 6.9 8.7 4.6 6.3 8.7 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein Esterase PF00756.20 EXF78704.1 - 5.5e-53 180.2 0.0 6.4e-53 180.0 0.0 1.0 1 0 0 1 1 1 1 Putative esterase Esterase_phd PF10503.9 EXF78704.1 - 6.9e-06 25.7 0.1 5.4e-05 22.8 0.1 2.0 1 1 0 1 1 1 1 Esterase PHB depolymerase Chlorophyllase2 PF12740.7 EXF78704.1 - 0.0012 17.8 0.0 0.0022 17.0 0.0 1.5 1 1 0 1 1 1 1 Chlorophyllase enzyme Hydrolase_4 PF12146.8 EXF78704.1 - 0.0038 16.5 0.0 0.006 15.9 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 EXF78704.1 - 0.0045 16.5 0.0 0.0081 15.7 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 EXF78704.1 - 0.018 15.6 0.0 0.023 15.3 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family Abhydrolase_2 PF02230.16 EXF78704.1 - 0.023 14.5 0.0 0.037 13.8 0.0 1.3 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase Chlorophyllase PF07224.11 EXF78704.1 - 0.072 12.1 0.0 0.17 10.8 0.0 1.6 2 0 0 2 2 2 0 Chlorophyllase PAF-AH_p_II PF03403.13 EXF78704.1 - 0.079 11.5 0.0 0.13 10.7 0.0 1.3 1 0 0 1 1 1 0 Platelet-activating factor acetylhydrolase, isoform II Lipase_3 PF01764.25 EXF78704.1 - 0.12 12.3 0.0 0.19 11.6 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) Zip PF02535.22 EXF78706.1 - 1.9e-33 116.1 9.6 5.2e-23 81.8 8.4 2.1 2 0 0 2 2 2 2 ZIP Zinc transporter SelP_N PF04592.14 EXF78706.1 - 1 8.7 24.6 0.44 9.9 18.2 2.4 2 0 0 2 2 2 0 Selenoprotein P, N terminal region DUF4271 PF14093.6 EXF78706.1 - 2.9 7.7 6.2 1.2 9.0 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4271) Endonuclease_NS PF01223.23 EXF78707.1 - 4.1e-67 226.3 0.0 5.3e-67 225.9 0.0 1.1 1 0 0 1 1 1 1 DNA/RNA non-specific endonuclease WD40 PF00400.32 EXF78708.1 - 4.9e-32 109.5 26.6 4e-05 24.3 0.0 7.4 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EXF78708.1 - 2.8e-14 53.2 0.1 0.018 15.4 0.0 6.1 2 1 5 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EXF78708.1 - 0.081 12.8 0.0 3.9 7.3 0.0 2.8 1 1 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A Frtz PF11768.8 EXF78708.1 - 0.17 10.1 0.0 0.29 9.4 0.0 1.3 1 0 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz Ge1_WD40 PF16529.5 EXF78708.1 - 0.2 10.6 0.3 17 4.3 0.0 3.1 1 1 2 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein MBOAT PF03062.19 EXF78709.1 - 8.6e-18 64.8 17.8 1.2e-17 64.3 17.8 1.3 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family MBOAT_2 PF13813.6 EXF78709.1 - 0.0069 16.6 1.7 0.018 15.3 1.7 1.8 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family ICMT PF04140.14 EXF78710.1 - 1.5e-27 95.9 1.0 3.3e-27 94.7 1.0 1.5 1 0 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 EXF78710.1 - 5.5e-13 49.2 3.6 5.5e-13 49.2 3.6 2.1 2 0 0 2 2 2 1 Phospholipid methyltransferase DUF1295 PF06966.12 EXF78710.1 - 0.00038 20.1 0.8 0.00052 19.6 0.8 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) NnrU PF07298.11 EXF78710.1 - 0.00068 19.2 2.4 0.00068 19.2 2.4 1.8 1 1 1 2 2 2 1 NnrU protein Steroid_dh PF02544.16 EXF78710.1 - 0.0037 17.2 3.8 0.0041 17.1 2.9 1.6 1 1 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase CCB1 PF12046.8 EXF78710.1 - 2.4 7.5 6.2 18 4.6 0.1 2.4 2 1 0 2 2 2 0 Cofactor assembly of complex C subunit B Mito_carr PF00153.27 EXF78711.1 - 6.1e-43 144.7 8.2 1.7e-16 59.9 0.2 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Fungal_trans PF04082.18 EXF78712.1 - 1.8e-25 89.5 0.0 9.1e-24 83.9 0.0 2.4 2 0 0 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF78712.1 - 1.8e-08 34.3 9.4 3.3e-08 33.5 9.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RIG-I_C PF18119.1 EXF78712.1 - 0.15 12.1 0.4 19 5.3 0.1 2.3 2 0 0 2 2 2 0 RIG-I receptor C-terminal domain p450 PF00067.22 EXF78715.1 - 1.9e-72 244.5 0.0 2.2e-72 244.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 ISN1 PF06437.11 EXF78716.1 - 7.9e-191 634.4 0.0 9e-191 634.2 0.0 1.0 1 0 0 1 1 1 1 IMP-specific 5'-nucleotidase DUF3175 PF11373.8 EXF78716.1 - 0.0086 16.2 0.0 0.018 15.2 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3175) DUF3446 PF11928.8 EXF78716.1 - 0.39 11.0 4.8 8.5 6.8 1.2 2.4 2 0 0 2 2 2 0 Early growth response N-terminal domain LPP PF04728.13 EXF78717.1 - 0.1 13.0 0.9 0.4 11.1 0.9 2.0 1 0 0 1 1 1 0 Lipoprotein leucine-zipper HSP70 PF00012.20 EXF78717.1 - 0.76 7.9 3.7 1.1 7.3 3.7 1.1 1 0 0 1 1 1 0 Hsp70 protein Pkinase PF00069.25 EXF78719.1 - 5.4e-51 173.5 0.0 7.4e-51 173.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF78719.1 - 1e-26 93.8 0.3 1.3e-25 90.2 0.2 2.3 2 1 0 2 2 2 1 Protein tyrosine kinase FTA2 PF13095.6 EXF78719.1 - 0.032 13.8 0.4 7.6 6.1 0.0 2.3 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 EXF78719.1 - 0.035 12.9 1.4 0.044 12.6 0.0 1.8 2 0 0 2 2 2 0 Fungal protein kinase Kinase-like PF14531.6 EXF78719.1 - 0.15 11.3 0.0 0.29 10.4 0.0 1.3 1 0 0 1 1 1 0 Kinase-like SUR7 PF06687.12 EXF78722.1 - 1.4e-30 106.5 15.2 1.8e-30 106.1 15.2 1.1 1 0 0 1 1 1 1 SUR7/PalI family DUF4834 PF16118.5 EXF78722.1 - 0.25 12.3 2.2 16 6.6 0.0 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF4834) DUF3742 PF12553.8 EXF78722.1 - 6.3 6.9 6.0 2.8 8.1 2.6 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3742) adh_short_C2 PF13561.6 EXF78723.1 - 2.4e-50 171.3 0.0 2.7e-50 171.1 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF78723.1 - 4.3e-44 150.3 0.0 5.3e-44 150.0 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EXF78723.1 - 1.1e-05 25.4 0.1 2.3e-05 24.4 0.0 1.5 2 0 0 2 2 2 1 KR domain Epimerase PF01370.21 EXF78723.1 - 0.062 12.8 0.0 0.15 11.5 0.0 1.7 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family DHHA1 PF02272.19 EXF78725.1 - 0.92 9.9 2.6 1.5 9.2 2.6 1.2 1 0 0 1 1 1 0 DHHA1 domain GST_N_4 PF17172.4 EXF78726.1 - 8.8e-21 74.5 0.1 9.7e-20 71.2 0.0 2.4 2 1 0 2 2 2 1 Glutathione S-transferase N-terminal domain GST_C_6 PF17171.4 EXF78726.1 - 3.7e-11 42.7 0.0 2e-10 40.3 0.0 2.2 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain Tom37 PF10568.9 EXF78726.1 - 2.5e-10 40.7 0.1 5.7e-10 39.6 0.0 1.6 1 1 1 2 2 2 1 Outer mitochondrial membrane transport complex protein SAM35 PF10806.8 EXF78726.1 - 0.028 14.7 0.0 0.054 13.8 0.0 1.5 1 0 0 1 1 1 0 SAM35, subunit of SAM coomplex DUF3433 PF11915.8 EXF78727.1 - 2.6e-35 120.7 22.6 1.4e-19 70.3 2.2 3.7 4 0 0 4 4 4 2 Protein of unknown function (DUF3433) TRP PF06011.12 EXF78728.1 - 1.9e-165 550.7 34.9 2.3e-165 550.5 34.9 1.1 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.6 EXF78728.1 - 4e-43 147.1 0.8 6.7e-43 146.4 0.8 1.4 1 0 0 1 1 1 1 ML-like domain TcpE PF12648.7 EXF78728.1 - 2 9.0 12.3 3.8 8.1 0.8 3.1 2 1 0 2 2 2 0 TcpE family DHO_dh PF01180.21 EXF78731.1 - 3.2e-17 62.7 0.0 1.8e-16 60.2 0.0 1.8 1 1 0 1 1 1 1 Dihydroorotate dehydrogenase NMO PF03060.15 EXF78731.1 - 0.00083 18.8 1.1 0.0012 18.3 1.1 1.2 1 0 0 1 1 1 1 Nitronate monooxygenase His_biosynth PF00977.21 EXF78731.1 - 0.089 12.2 0.2 0.14 11.6 0.2 1.2 1 0 0 1 1 1 0 Histidine biosynthesis protein MFS_1 PF07690.16 EXF78732.1 - 1e-11 44.4 38.6 5.5e-10 38.7 17.7 4.5 3 2 1 4 4 4 3 Major Facilitator Superfamily HSP70 PF00012.20 EXF78735.1 - 3.2e-219 729.1 7.3 3.6e-219 728.9 7.3 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EXF78735.1 - 4.8e-16 58.5 0.2 4.3e-15 55.3 0.1 2.0 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.16 EXF78735.1 - 0.0038 17.0 0.0 0.0078 16.0 0.0 1.4 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain DDR PF08841.10 EXF78735.1 - 0.017 14.1 0.9 0.054 12.5 0.3 2.1 2 1 0 2 2 2 0 Diol dehydratase reactivase ATPase-like domain XRN1_DBM PF18245.1 EXF78736.1 - 0.27 11.2 1.8 6 7.0 0.1 2.8 2 0 0 2 2 2 0 5-3 exonuclease XRN1 DCP1-binding motif IF4E PF01652.18 EXF78737.1 - 4.1e-54 182.7 0.1 5.3e-54 182.3 0.1 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E AMP-binding PF00501.28 EXF78738.1 - 3.9e-72 243.2 0.2 1.8e-35 122.4 0.0 2.1 2 0 0 2 2 2 2 AMP-binding enzyme AMP-binding_C PF13193.6 EXF78738.1 - 2.3e-11 44.5 0.2 4.8e-11 43.5 0.2 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Collagen PF01391.18 EXF78738.1 - 0.045 13.5 0.6 0.095 12.5 0.6 1.4 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) BolA PF01722.18 EXF78739.1 - 1.8e-28 98.6 1.9 2.9e-28 97.9 1.9 1.4 1 0 0 1 1 1 1 BolA-like protein PIP5K PF01504.18 EXF78741.1 - 1.4e-30 106.4 0.0 3.7e-22 78.8 0.0 2.7 1 1 1 2 2 2 2 Phosphatidylinositol-4-phosphate 5-Kinase Cpn60_TCP1 PF00118.24 EXF78741.1 - 1.5e-25 89.8 0.0 2.3e-25 89.2 0.0 1.2 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family FYVE PF01363.21 EXF78741.1 - 1.8e-13 50.4 10.9 4.4e-13 49.2 10.9 1.7 1 0 0 1 1 1 1 FYVE zinc finger MMM1 PF10296.9 EXF78741.1 - 9.7e-05 21.6 0.0 0.00025 20.2 0.0 1.7 1 0 0 1 1 1 1 Maintenance of mitochondrial morphology protein 1 GPAT_N PF14829.6 EXF78741.1 - 0.19 11.7 0.1 0.57 10.2 0.1 1.8 1 0 0 1 1 1 0 Glycerol-3-phosphate acyltransferase N-terminal FYVE_2 PF02318.16 EXF78741.1 - 0.71 10.1 5.4 2 8.7 5.4 1.7 1 0 0 1 1 1 0 FYVE-type zinc finger VPS28 PF03997.12 EXF78742.1 - 1.1e-68 230.6 0.1 1.3e-68 230.4 0.1 1.0 1 0 0 1 1 1 1 VPS28 protein Noc2 PF03715.13 EXF78743.1 - 1.6e-127 424.9 0.3 1.6e-127 424.9 0.3 2.0 2 0 0 2 2 2 1 Noc2p family Nop14 PF04147.12 EXF78743.1 - 0.00076 17.8 0.1 0.00076 17.8 0.1 4.0 2 2 1 3 3 3 1 Nop14-like family DUF726 PF05277.12 EXF78744.1 - 1.3e-121 405.7 0.2 1.7e-121 405.3 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF726) Thioesterase PF00975.20 EXF78744.1 - 0.00089 19.4 0.0 0.0018 18.5 0.0 1.4 1 0 0 1 1 1 1 Thioesterase domain Abhydrolase_6 PF12697.7 EXF78744.1 - 0.033 14.8 0.1 0.1 13.2 0.1 1.8 1 0 0 1 1 1 0 Alpha/beta hydrolase family PE-PPE PF08237.11 EXF78744.1 - 0.059 12.9 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 PE-PPE domain PIR PF00399.19 EXF78745.1 - 0.25 11.0 1.7 0.61 9.7 1.7 1.7 1 0 0 1 1 1 0 Yeast PIR protein repeat DUF1656 PF07869.12 EXF78746.1 - 0.11 12.6 2.8 0.18 11.8 2.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1656) Bromodomain PF00439.25 EXF78747.1 - 1.8e-24 85.6 0.6 4e-24 84.5 0.6 1.6 1 0 0 1 1 1 1 Bromodomain Acetyltransf_1 PF00583.25 EXF78747.1 - 6.3e-08 32.9 0.0 1.1e-07 32.1 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EXF78747.1 - 5.5e-07 29.6 0.3 1.7e-06 28.0 0.1 1.8 1 1 1 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EXF78747.1 - 0.00032 21.1 0.4 0.00061 20.2 0.1 1.6 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EXF78747.1 - 0.097 12.7 0.0 0.22 11.5 0.0 1.6 1 0 0 1 1 1 0 FR47-like protein Acetyltransf_3 PF13302.7 EXF78747.1 - 0.11 13.2 0.0 5.3 7.7 0.0 2.3 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Rad1 PF02144.16 EXF78748.1 - 3.1e-65 220.0 0.0 3.7e-65 219.7 0.0 1.1 1 0 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 Ost5 PF05251.12 EXF78748.1 - 4.9e-09 36.3 6.2 1.1e-08 35.3 5.7 1.8 2 0 0 2 2 2 1 Oligosaccharyltransferase subunit 5 DUF4698 PF15769.5 EXF78749.1 - 1.3 8.0 5.7 1.5 7.8 5.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4698) Zn_clus PF00172.18 EXF78751.1 - 1.3e-06 28.4 10.2 2.8e-06 27.4 10.2 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.16 EXF78752.1 - 7.6e-38 130.3 65.1 7.6e-38 130.3 65.1 2.0 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EXF78752.1 - 1.3e-12 47.0 33.4 2.5e-12 46.0 33.4 1.4 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EXF78752.1 - 7.9e-10 38.2 16.1 7.9e-10 38.2 16.1 3.1 2 1 0 3 3 3 2 Sugar (and other) transporter DUF1772 PF08592.11 EXF78755.1 - 9.6e-30 103.7 7.8 1.2e-29 103.3 7.8 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1772) Phage_holin_3_1 PF05106.12 EXF78755.1 - 0.24 11.8 4.2 0.11 12.9 0.4 2.3 1 1 2 3 3 3 0 Phage holin family (Lysis protein S) Acetyltransf_3 PF13302.7 EXF78756.1 - 2.9e-32 112.2 0.0 4.1e-32 111.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EXF78756.1 - 0.14 12.1 0.0 0.32 11.0 0.0 1.6 1 0 0 1 1 1 0 FR47-like protein Fungal_trans PF04082.18 EXF78757.1 - 5.1e-20 71.6 0.0 8.5e-20 70.9 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF78757.1 - 4.4e-08 33.1 15.2 6.6e-08 32.6 15.2 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Ribosomal_60s PF00428.19 EXF78757.1 - 0.0037 17.8 9.7 0.0037 17.8 9.7 3.9 4 0 0 4 4 4 1 60s Acidic ribosomal protein Myc_N PF01056.18 EXF78757.1 - 1.6 8.6 4.8 0.25 11.2 0.7 1.7 2 0 0 2 2 2 0 Myc amino-terminal region Clusterin PF01093.17 EXF78757.1 - 2.2 7.2 5.1 4.1 6.3 5.1 1.3 1 0 0 1 1 1 0 Clusterin BUD22 PF09073.10 EXF78757.1 - 6.9 5.9 10.2 6.2 6.1 5.3 2.1 2 0 0 2 2 2 0 BUD22 Ribosomal_L18A PF01775.17 EXF78758.1 - 3.3e-54 182.1 0.3 4.1e-54 181.8 0.3 1.1 1 0 0 1 1 1 1 Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A DUF4988 PF16378.5 EXF78758.1 - 0.15 11.7 0.0 0.2 11.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function PCI PF01399.27 EXF78759.1 - 8.1e-11 42.4 0.0 2.7e-10 40.7 0.0 1.9 2 0 0 2 2 2 1 PCI domain BTB PF00651.31 EXF78760.1 - 1.7e-06 28.2 0.0 6.2e-06 26.4 0.0 1.9 2 0 0 2 2 2 1 BTB/POZ domain Abhydrolase_6 PF12697.7 EXF78761.1 - 6.9e-05 23.6 2.2 8e-05 23.3 0.4 2.0 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.13 EXF78761.1 - 0.0026 17.6 0.0 0.0058 16.5 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EXF78761.1 - 0.0031 16.8 0.0 0.11 11.7 0.0 2.2 1 1 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EXF78761.1 - 0.0063 16.2 0.0 0.049 13.3 0.0 2.1 1 1 1 2 2 2 1 alpha/beta hydrolase fold LRR_4 PF12799.7 EXF78762.1 - 1.2e-40 136.8 41.1 1.7e-07 31.4 0.1 6.8 1 1 8 10 10 10 10 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EXF78762.1 - 4.5e-23 80.8 24.5 3.9e-07 29.7 3.1 5.3 2 2 2 5 5 5 5 Leucine rich repeat LRR_9 PF14580.6 EXF78762.1 - 6.4e-15 55.1 9.4 2.1e-09 37.1 4.0 3.5 1 1 2 3 3 3 3 Leucine-rich repeat LRR_6 PF13516.6 EXF78762.1 - 4e-06 26.5 16.9 1.4 9.2 0.2 8.5 10 0 0 10 10 10 2 Leucine Rich repeat LRR_1 PF00560.33 EXF78762.1 - 2.7e-05 24.1 13.1 29 5.8 0.0 8.7 9 2 0 9 9 9 1 Leucine Rich Repeat Aldo_ket_red PF00248.21 EXF78763.1 - 4.9e-40 137.6 0.0 6.1e-40 137.2 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family FOXO_KIX_bdg PF16675.5 EXF78763.1 - 0.21 11.9 0.0 0.41 11.0 0.0 1.5 1 0 0 1 1 1 0 KIX-binding domain of forkhead box O, CR2 Pkinase PF00069.25 EXF78764.1 - 2e-10 40.5 0.0 3.8e-07 29.7 0.0 3.2 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EXF78764.1 - 2.8e-09 36.6 0.0 0.021 14.1 0.0 3.3 3 0 0 3 3 3 3 Protein tyrosine kinase ABC_membrane_2 PF06472.15 EXF78766.1 - 7.1e-94 314.2 1.8 5.8e-93 311.2 0.1 2.5 3 0 0 3 3 3 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 EXF78766.1 - 1.5e-16 61.1 0.0 4e-16 59.8 0.0 1.7 2 0 0 2 2 2 1 ABC transporter AAA_21 PF13304.6 EXF78766.1 - 0.0045 16.8 0.0 0.0096 15.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 EXF78766.1 - 0.0052 17.2 0.2 0.016 15.6 0.0 1.9 2 0 0 2 2 1 1 AAA ATPase domain THOC7 PF05615.13 EXF78766.1 - 0.014 15.7 1.1 0.035 14.4 1.1 1.6 1 0 0 1 1 1 0 Tho complex subunit 7 AAA PF00004.29 EXF78766.1 - 0.014 15.8 0.0 0.038 14.4 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EXF78766.1 - 0.019 14.7 0.0 0.045 13.5 0.0 1.5 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain End3 PF12761.7 EXF78766.1 - 0.021 15.0 0.7 0.062 13.5 0.6 1.7 2 0 0 2 2 2 0 Actin cytoskeleton-regulatory complex protein END3 ALIX_LYPXL_bnd PF13949.6 EXF78766.1 - 0.047 13.0 0.1 0.097 11.9 0.1 1.4 1 0 0 1 1 1 0 ALIX V-shaped domain binding to HIV Mg_chelatase PF01078.21 EXF78766.1 - 0.066 12.6 0.0 0.12 11.8 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 EXF78766.1 - 0.09 12.5 0.0 1.7 8.3 0.0 2.6 2 0 0 2 2 2 0 IstB-like ATP binding protein Sigma54_activat PF00158.26 EXF78766.1 - 0.15 11.7 0.0 0.32 10.7 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_7 PF12775.7 EXF78766.1 - 0.21 11.1 0.0 0.43 10.1 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_23 PF13476.6 EXF78766.1 - 0.22 12.0 9.5 5.2 7.5 9.5 2.5 1 1 0 1 1 1 0 AAA domain bZIP_2 PF07716.15 EXF78766.1 - 3.6 7.7 12.4 1.3 9.2 2.3 3.1 3 0 0 3 3 3 0 Basic region leucine zipper NIF PF03031.18 EXF78767.1 - 7.5e-54 181.7 0.4 1.1e-53 181.2 0.4 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Sec61_beta PF03911.16 EXF78767.1 - 3.4e-18 65.4 1.9 5.7e-18 64.7 1.9 1.4 1 0 0 1 1 1 1 Sec61beta family Glyco_transf_28 PF03033.20 EXF78768.1 - 8.2e-19 68.0 0.6 1e-10 41.8 0.0 2.5 2 0 0 2 2 2 2 Glycosyltransferase family 28 N-terminal domain UDPGT PF00201.18 EXF78768.1 - 6e-06 25.3 0.0 1e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase ATG_C PF09333.11 EXF78768.1 - 0.00013 22.2 0.0 0.0005 20.4 0.0 2.0 1 0 0 1 1 1 1 Autophagy-related protein C terminal domain Glyco_tran_28_C PF04101.16 EXF78768.1 - 0.025 14.6 0.3 0.093 12.7 0.0 2.0 2 0 0 2 2 2 0 Glycosyltransferase family 28 C-terminal domain UIM PF02809.20 EXF78768.1 - 0.4 10.7 34.4 0.77 9.8 4.3 6.3 6 0 0 6 6 6 0 Ubiquitin interaction motif Ribosomal_L6e PF01159.19 EXF78769.1 - 2 9.0 6.0 5.8 7.5 6.0 1.7 1 0 0 1 1 1 0 Ribosomal protein L6e DUF3987 PF13148.6 EXF78769.1 - 4 6.4 6.3 8.3 5.3 6.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) NARP1 PF12569.8 EXF78769.1 - 9.4 5.0 9.8 15 4.4 9.8 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 PAF-AH_p_II PF03403.13 EXF78770.1 - 3.3e-48 164.1 0.1 5.1e-44 150.3 0.0 3.0 2 1 0 2 2 2 1 Platelet-activating factor acetylhydrolase, isoform II Chlorophyllase2 PF12740.7 EXF78770.1 - 2e-08 33.4 0.0 6.8e-07 28.4 0.0 2.2 2 0 0 2 2 2 1 Chlorophyllase enzyme Chlorophyllase PF07224.11 EXF78770.1 - 5.4e-07 28.9 0.0 3.4e-05 23.0 0.0 2.3 2 0 0 2 2 2 1 Chlorophyllase Hydrolase_4 PF12146.8 EXF78770.1 - 9.1e-05 21.8 0.0 0.13 11.5 0.0 2.3 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EXF78770.1 - 0.052 14.1 1.4 0.29 11.7 0.1 2.4 3 1 0 3 3 3 0 Alpha/beta hydrolase family Abhydrolase_2 PF02230.16 EXF78770.1 - 0.078 12.8 0.0 2.9 7.6 0.0 2.2 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase DLH PF01738.18 EXF78770.1 - 0.12 11.9 0.0 0.79 9.2 0.0 2.1 2 0 0 2 2 2 0 Dienelactone hydrolase family Fungal_trans PF04082.18 EXF78771.1 - 1.1e-11 44.3 0.0 1.7e-11 43.7 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain KAR9 PF08580.10 EXF78771.1 - 4.4 5.7 8.5 6.6 5.1 8.5 1.1 1 0 0 1 1 1 0 Yeast cortical protein KAR9 COesterase PF00135.28 EXF78773.1 - 6.9e-70 236.4 0.0 3.1e-62 211.1 0.0 2.0 1 1 1 2 2 2 2 Carboxylesterase family Abhydrolase_3 PF07859.13 EXF78773.1 - 2.5e-06 27.5 0.2 6.4e-05 22.9 0.1 2.6 2 1 0 2 2 2 1 alpha/beta hydrolase fold MFS_1 PF07690.16 EXF78774.1 - 7.6e-24 84.3 26.9 7.6e-24 84.3 26.9 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Vma12 PF11712.8 EXF78774.1 - 0.39 10.8 2.0 1.2 9.2 0.1 2.4 2 0 0 2 2 2 0 Endoplasmic reticulum-based factor for assembly of V-ATPase DUF1184 PF06683.11 EXF78775.1 - 0.14 11.7 0.0 0.21 11.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1184) Fungal_trans PF04082.18 EXF78777.1 - 6.5e-18 64.7 0.1 1.2e-17 63.8 0.1 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Carboxyl_trans PF01039.22 EXF78778.1 - 3.1e-100 336.2 0.0 4.9e-100 335.5 0.0 1.2 1 0 0 1 1 1 1 Carboxyl transferase domain HMGL-like PF00682.19 EXF78778.1 - 5.5e-44 150.7 0.0 1.1e-43 149.7 0.0 1.5 1 0 0 1 1 1 1 HMGL-like ECH_1 PF00378.20 EXF78778.1 - 3.4e-42 144.5 0.3 7e-41 140.2 0.0 2.7 3 0 0 3 3 3 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EXF78778.1 - 1.8e-27 96.8 0.0 3.1e-27 96.0 0.0 1.4 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase AMP-binding PF00501.28 EXF78779.1 - 3.1e-95 319.3 0.0 3.8e-95 319.0 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EXF78779.1 - 1.2e-14 55.0 0.0 4.1e-14 53.3 0.0 2.0 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain CPSase_L_D2 PF02786.17 EXF78780.1 - 3.8e-69 232.4 0.0 5.7e-69 231.8 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 EXF78780.1 - 2.9e-41 140.5 0.1 1.4e-40 138.3 0.1 2.1 2 0 0 2 2 2 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 EXF78780.1 - 1.3e-26 92.8 0.0 2.4e-26 92.0 0.0 1.4 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain ATP-grasp PF02222.22 EXF78780.1 - 3.1e-12 46.4 0.1 6.8e-12 45.3 0.1 1.6 1 0 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.13 EXF78780.1 - 2.1e-09 37.2 0.0 5.2e-09 35.9 0.0 1.6 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp_3 PF02655.14 EXF78780.1 - 2.3e-07 31.0 0.0 4e-07 30.2 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain Biotin_lipoyl PF00364.22 EXF78780.1 - 2.6e-06 27.2 4.3 7.1e-06 25.8 4.3 1.8 1 1 0 1 1 1 1 Biotin-requiring enzyme WH1 PF00568.23 EXF78780.1 - 0.075 13.0 0.0 2.5 8.1 0.0 2.8 3 0 0 3 3 3 0 WH1 domain SnoaL_2 PF12680.7 EXF78781.1 - 0.0022 18.6 0.0 0.003 18.2 0.0 1.3 1 0 0 1 1 1 1 SnoaL-like domain adh_short PF00106.25 EXF78782.1 - 4.7e-27 94.7 0.1 8e-27 94.0 0.1 1.3 1 0 0 1 1 1 1 short chain dehydrogenase DUF3176 PF11374.8 EXF78782.1 - 7.5e-26 90.4 3.6 1e-25 90.0 1.5 2.3 2 1 0 2 2 2 1 Protein of unknown function (DUF3176) adh_short_C2 PF13561.6 EXF78782.1 - 3e-17 63.0 0.3 5.2e-17 62.2 0.3 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF78782.1 - 7.9e-07 29.2 0.1 1.5e-06 28.2 0.1 1.4 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EXF78782.1 - 0.00017 21.2 0.2 0.013 15.0 0.2 2.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EXF78782.1 - 0.0082 16.1 0.1 0.019 14.9 0.1 1.6 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EXF78782.1 - 0.054 13.0 0.4 0.093 12.3 0.4 1.3 1 0 0 1 1 1 0 NmrA-like family p450 PF00067.22 EXF78783.1 - 9.6e-44 149.9 0.0 2.7e-43 148.4 0.0 1.5 1 1 0 1 1 1 1 Cytochrome P450 Methyltransf_11 PF08241.12 EXF78784.1 - 2.7e-16 60.0 0.0 4.8e-16 59.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF78784.1 - 2e-15 57.2 0.0 3.6e-15 56.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF78784.1 - 2e-10 41.3 0.0 3.2e-10 40.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF78784.1 - 1.2e-07 31.7 0.0 2.1e-07 30.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EXF78784.1 - 3.3e-07 30.3 0.0 5.3e-07 29.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EXF78784.1 - 0.00041 19.8 0.0 0.00062 19.2 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family CMAS PF02353.20 EXF78784.1 - 0.024 13.9 0.0 0.076 12.3 0.0 1.8 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase DREV PF05219.12 EXF78784.1 - 0.036 13.2 0.0 0.054 12.6 0.0 1.2 1 0 0 1 1 1 0 DREV methyltransferase MTS PF05175.14 EXF78784.1 - 0.05 13.2 0.0 0.28 10.7 0.0 1.9 1 1 0 1 1 1 0 Methyltransferase small domain p450 PF00067.22 EXF78786.1 - 4.6e-66 223.5 0.0 2e-61 208.2 0.0 2.0 2 0 0 2 2 2 2 Cytochrome P450 zf-CCHC_5 PF14787.6 EXF78787.1 - 0.11 12.2 4.5 0.27 11.0 0.9 2.6 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger Metallophos PF00149.28 EXF78788.1 - 1.7e-09 38.5 3.0 3.8e-09 37.4 3.0 1.7 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Glyco_hydro_3_C PF01915.22 EXF78789.1 - 9.6e-64 215.1 0.0 1.8e-63 214.2 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 EXF78789.1 - 3.7e-54 184.3 0.0 5.6e-54 183.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 EXF78789.1 - 1.8e-22 79.2 0.1 3.8e-22 78.2 0.1 1.6 1 0 0 1 1 1 1 Fibronectin type III-like domain PA14 PF07691.12 EXF78789.1 - 2.4e-22 79.3 0.0 3.7e-22 78.7 0.0 1.3 1 0 0 1 1 1 1 PA14 domain Croc_4 PF17691.1 EXF78790.1 - 0.066 13.3 0.2 0.11 12.6 0.2 1.4 1 1 0 1 1 1 0 Contingent replication of cDNA 4 gag-asp_proteas PF13975.6 EXF78791.1 - 1.6e-12 47.8 0.0 1.6e-05 25.4 0.0 2.5 2 0 0 2 2 2 2 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 EXF78791.1 - 6.8e-12 45.9 0.0 7e-06 26.6 0.0 2.3 2 0 0 2 2 2 2 Aspartyl protease RVP PF00077.20 EXF78791.1 - 0.0029 17.9 0.0 1.7 9.0 0.0 2.4 2 0 0 2 2 2 2 Retroviral aspartyl protease RVP_2 PF08284.11 EXF78791.1 - 0.011 15.5 0.0 0.14 12.0 0.0 2.1 2 0 0 2 2 2 0 Retroviral aspartyl protease Asp_protease PF09668.10 EXF78791.1 - 0.032 14.0 0.0 8.8 6.1 0.0 2.6 2 1 0 2 2 2 0 Aspartyl protease DUF2384 PF09722.10 EXF78792.1 - 0.15 12.1 2.1 0.45 10.6 0.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2384) Cation_efflux PF01545.21 EXF78793.1 - 1.5e-51 175.0 10.3 7.4e-51 172.7 10.3 1.8 1 1 0 1 1 1 1 Cation efflux family Macoilin PF09726.9 EXF78793.1 - 0.0036 15.9 1.1 0.0047 15.6 1.1 1.2 1 0 0 1 1 1 1 Macoilin family Peptidase_M1_N PF17900.1 EXF78794.1 - 1.6e-06 28.4 0.0 0.003 17.8 0.0 2.6 2 0 0 2 2 2 2 Peptidase M1 N-terminal domain HEAT PF02985.22 EXF78794.1 - 0.18 12.2 0.1 11 6.6 0.0 2.8 2 0 0 2 2 2 0 HEAT repeat SAS4 PF15460.6 EXF78795.1 - 5.5e-32 109.8 0.1 2.2e-31 107.9 0.1 2.1 1 0 0 1 1 1 1 Something about silencing, SAS, complex subunit 4 SDA1 PF05285.12 EXF78795.1 - 0.0053 16.2 9.8 0.01 15.3 9.8 1.4 1 0 0 1 1 1 1 SDA1 Adaptin_binding PF10199.9 EXF78795.1 - 0.13 12.9 9.7 0.72 10.5 9.7 2.3 1 1 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 CDC45 PF02724.14 EXF78795.1 - 1.1 7.5 10.7 1.7 6.9 10.7 1.3 1 0 0 1 1 1 0 CDC45-like protein F-box-like PF12937.7 EXF78796.1 - 0.0022 17.8 0.0 0.0038 17.1 0.0 1.4 1 0 0 1 1 1 1 F-box-like CDP-OH_P_transf PF01066.21 EXF78797.1 - 5.5e-16 59.1 0.3 5.5e-16 59.1 0.3 2.7 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase DUF4746 PF15928.5 EXF78799.1 - 0.12 11.8 0.0 0.17 11.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) IQ PF00612.27 EXF78800.1 - 0.00022 20.7 1.3 0.00064 19.3 1.3 1.9 1 0 0 1 1 1 1 IQ calmodulin-binding motif DUF4247 PF14042.6 EXF78800.1 - 0.076 13.7 0.1 0.076 13.7 0.1 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4247) SSP160 PF06933.11 EXF78800.1 - 0.52 8.5 12.8 1.1 7.4 12.8 1.4 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 AAA_23 PF13476.6 EXF78800.1 - 3.7 8.0 11.0 3.2 8.2 2.4 2.9 3 0 0 3 3 3 0 AAA domain F-box PF00646.33 EXF78801.1 - 0.00097 19.0 0.2 0.0022 17.8 0.2 1.6 1 0 0 1 1 1 1 F-box domain TPP_enzyme_N PF02776.18 EXF78802.1 - 2e-41 141.5 0.1 9.8e-41 139.2 0.0 2.1 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 EXF78802.1 - 2.2e-23 82.8 1.2 2.2e-23 82.8 1.2 2.1 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 EXF78802.1 - 3.3e-23 82.0 0.0 5.6e-23 81.2 0.0 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain ABC2_membrane PF01061.24 EXF78803.1 - 2.2e-91 304.9 51.0 2.2e-47 161.2 21.9 2.6 3 0 0 3 3 3 2 ABC-2 type transporter ABC_tran PF00005.27 EXF78803.1 - 2e-35 122.3 0.0 5.6e-16 59.3 0.0 3.3 3 0 0 3 3 3 2 ABC transporter PDR_CDR PF06422.12 EXF78803.1 - 1e-34 118.3 3.5 1.3e-31 108.3 0.1 3.4 3 0 0 3 3 3 2 CDR ABC transporter ABC_trans_N PF14510.6 EXF78803.1 - 8.3e-15 55.2 0.1 2.1e-14 53.9 0.1 1.7 1 0 0 1 1 1 1 ABC-transporter N-terminal AAA_16 PF13191.6 EXF78803.1 - 2.9e-07 31.0 0.4 0.00012 22.5 0.2 2.7 2 0 0 2 2 2 1 AAA ATPase domain AAA_25 PF13481.6 EXF78803.1 - 1.2e-05 25.0 0.0 0.00022 20.9 0.0 2.4 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 EXF78803.1 - 2.2e-05 24.4 0.0 0.0016 18.4 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase AAA_21 PF13304.6 EXF78803.1 - 0.0002 21.3 0.0 1.3 8.8 0.0 3.1 2 1 1 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EXF78803.1 - 0.00023 20.8 0.3 0.036 13.8 0.1 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_33 PF13671.6 EXF78803.1 - 0.0005 20.3 0.1 0.078 13.1 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EXF78803.1 - 0.00059 20.4 0.0 0.12 13.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EXF78803.1 - 0.003 17.3 0.2 0.21 11.3 0.1 2.3 2 0 0 2 2 2 1 AAA domain SMC_N PF02463.19 EXF78803.1 - 0.0036 16.7 0.0 2.8 7.3 0.0 3.7 3 1 0 3 3 3 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 EXF78803.1 - 0.0041 17.4 0.1 0.66 10.3 0.0 2.7 2 0 0 2 2 2 1 AAA domain cobW PF02492.19 EXF78803.1 - 0.0064 16.1 0.6 0.11 12.1 0.1 2.3 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.12 EXF78803.1 - 0.0075 16.2 0.0 2.3 8.1 0.1 2.6 2 0 0 2 2 2 1 NACHT domain AAA_17 PF13207.6 EXF78803.1 - 0.013 15.9 0.6 3.8 7.9 0.0 3.1 4 0 0 4 4 2 0 AAA domain AAA PF00004.29 EXF78803.1 - 0.035 14.5 0.0 6.5 7.2 0.0 2.5 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_23 PF13476.6 EXF78803.1 - 0.056 13.9 0.0 0.18 12.3 0.0 1.8 1 0 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.18 EXF78803.1 - 0.19 11.5 0.0 3.6 7.3 0.0 2.2 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase ABC2_membrane_3 PF12698.7 EXF78803.1 - 4.9 6.2 45.1 0.0067 15.6 14.8 3.2 2 1 0 2 2 1 0 ABC-2 family transporter protein NPP1 PF05630.11 EXF78804.1 - 1.9e-37 129.3 0.0 1.6e-36 126.3 0.0 2.0 1 1 0 1 1 1 1 Necrosis inducing protein (NPP1) DUF1294 PF06961.13 EXF78806.1 - 0.17 12.1 0.0 1.4 9.2 0.0 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1294) adh_short PF00106.25 EXF78808.1 - 1.9e-38 131.9 0.0 2.6e-38 131.4 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF78808.1 - 1.2e-26 93.7 0.3 1.6e-26 93.4 0.3 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.6 EXF78808.1 - 1.6e-08 34.6 1.0 3e-08 33.8 0.7 1.8 1 1 0 1 1 1 1 NAD(P)H-binding KR PF08659.10 EXF78808.1 - 3.6e-07 30.3 0.6 5.8e-07 29.6 0.2 1.5 2 0 0 2 2 2 1 KR domain Epimerase PF01370.21 EXF78808.1 - 8.3e-06 25.4 0.1 1.2e-05 24.9 0.1 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family F420_oxidored PF03807.17 EXF78808.1 - 0.0053 17.3 0.3 0.11 13.1 0.0 2.4 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent ADH_zinc_N PF00107.26 EXF78808.1 - 0.0062 16.5 0.4 0.019 14.9 0.2 2.0 2 1 0 2 2 2 1 Zinc-binding dehydrogenase DFP PF04127.15 EXF78808.1 - 0.016 15.1 0.1 0.024 14.5 0.1 1.4 1 0 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein NmrA PF05368.13 EXF78808.1 - 0.029 13.9 0.1 0.065 12.8 0.1 1.5 1 1 0 1 1 1 0 NmrA-like family RmlD_sub_bind PF04321.17 EXF78808.1 - 0.052 12.6 0.2 0.097 11.8 0.2 1.4 1 0 0 1 1 1 0 RmlD substrate binding domain DUF1776 PF08643.10 EXF78808.1 - 0.055 12.8 0.0 0.068 12.5 0.0 1.1 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) YjeF_N PF03853.15 EXF78808.1 - 0.065 13.1 0.2 0.25 11.2 0.1 1.9 2 0 0 2 2 2 0 YjeF-related protein N-terminus Peptidase_M28 PF04389.17 EXF78809.1 - 4.3e-35 121.2 0.0 5.4e-35 120.9 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M28 Ribophorin_II PF05817.14 EXF78810.1 - 5.2e-33 114.5 0.0 6.4e-33 114.2 0.0 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase subunit Ribophorin II Glyco_hydro_76 PF03663.14 EXF78812.1 - 9.3e-21 74.7 3.4 1.5e-18 67.5 3.4 2.9 1 1 0 1 1 1 1 Glycosyl hydrolase family 76 Cep57_CLD_2 PF14197.6 EXF78813.1 - 1.5e-30 105.0 58.6 1.8e-17 63.2 4.8 5.9 5 1 0 5 5 5 2 Centrosome localisation domain of PPC89 Cep57_MT_bd PF06657.13 EXF78813.1 - 2.4e-28 98.4 0.3 2.4e-28 98.4 0.3 6.7 7 1 0 7 7 7 1 Centrosome microtubule-binding domain of Cep57 ATG16 PF08614.11 EXF78813.1 - 1e-05 25.9 34.3 1e-05 25.9 34.3 7.1 5 2 2 7 7 7 1 Autophagy protein 16 (ATG16) KASH_CCD PF14662.6 EXF78813.1 - 0.021 14.6 0.5 0.021 14.6 0.5 6.2 3 1 4 7 7 7 0 Coiled-coil region of CCDC155 or KASH MLD PF11647.8 EXF78813.1 - 0.035 14.4 0.1 0.2 11.9 0.1 2.3 1 0 0 1 1 1 0 Membrane Localization Domain HALZ PF02183.18 EXF78813.1 - 0.035 14.3 0.7 0.035 14.3 0.7 7.4 6 2 3 9 9 9 0 Homeobox associated leucine zipper DUF730 PF05325.11 EXF78813.1 - 1.2 9.2 10.3 0.067 13.2 0.8 3.5 4 0 0 4 4 4 0 Protein of unknown function (DUF730) Pox_A_type_inc PF04508.12 EXF78813.1 - 4.1 7.4 6.8 1.5 8.8 0.0 3.5 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat NmrA PF05368.13 EXF78814.1 - 9.9e-06 25.3 0.0 1.4e-05 24.8 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EXF78814.1 - 2.2e-05 24.4 0.0 4.1e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 NAD(P)H-binding Glyco_transf_4 PF13439.6 EXF78814.1 - 0.047 13.7 0.0 0.075 13.0 0.0 1.4 1 0 0 1 1 1 0 Glycosyltransferase Family 4 ApbA PF02558.16 EXF78814.1 - 0.19 11.3 0.0 0.32 10.6 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Fungal_trans_2 PF11951.8 EXF78815.1 - 4.8e-24 84.9 4.4 1.2e-11 44.1 1.5 2.1 2 0 0 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF78815.1 - 1.4e-09 37.9 5.6 2.7e-09 37.0 5.6 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Ank_2 PF12796.7 EXF78816.1 - 1.7e-69 230.4 0.0 9.3e-16 58.2 0.0 6.6 1 1 5 6 6 6 6 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EXF78816.1 - 1.9e-51 166.0 4.5 0.00076 19.8 0.0 12.7 12 0 0 12 12 12 10 Ankyrin repeat Ank_4 PF13637.6 EXF78816.1 - 4.2e-49 164.3 1.7 2.1e-07 31.4 0.0 10.0 4 3 6 10 10 10 10 Ankyrin repeats (many copies) Ank PF00023.30 EXF78816.1 - 1.4e-48 161.3 7.2 4.6e-05 23.7 0.0 12.8 12 0 0 12 12 12 11 Ankyrin repeat Ank_5 PF13857.6 EXF78816.1 - 8.2e-48 159.8 5.3 1.2e-06 28.7 0.0 9.8 3 3 7 10 10 10 10 Ankyrin repeats (many copies) An_peroxidase PF03098.15 EXF78817.1 - 2.9e-116 389.1 0.0 3.6e-116 388.9 0.0 1.0 1 0 0 1 1 1 1 Animal haem peroxidase RhoGAP PF00620.27 EXF78818.1 - 5e-48 162.8 0.0 1.1e-47 161.6 0.0 1.6 1 0 0 1 1 1 1 RhoGAP domain FCH PF00611.23 EXF78818.1 - 2.5e-11 43.7 0.8 6.8e-11 42.3 0.8 1.8 1 0 0 1 1 1 1 Fes/CIP4, and EFC/F-BAR homology domain DUF4407 PF14362.6 EXF78818.1 - 0.034 13.5 5.2 0.058 12.7 5.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) OmpH PF03938.14 EXF78818.1 - 0.22 11.8 11.4 0.053 13.9 7.1 2.1 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) CMS1 PF14617.6 EXF78819.1 - 3.2e-83 278.9 0.6 3.5e-83 278.8 0.6 1.0 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit DEAD PF00270.29 EXF78819.1 - 7.1e-08 32.4 0.0 9.7e-08 32.0 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Herpes_glycop PF01528.16 EXF78819.1 - 0.16 10.7 0.1 0.23 10.3 0.1 1.1 1 0 0 1 1 1 0 Herpesvirus glycoprotein M RRM_1 PF00076.22 EXF78820.1 - 9.1e-10 38.2 0.0 2.8e-09 36.6 0.0 1.9 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ras PF00071.22 EXF78821.1 - 3.6e-54 182.7 0.0 4.1e-54 182.5 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EXF78821.1 - 1.9e-21 76.5 0.0 2.7e-21 76.0 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EXF78821.1 - 8.5e-07 28.6 0.0 1.1e-06 28.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Epimerase PF01370.21 EXF78822.1 - 6.3e-12 45.5 0.0 1.1e-11 44.6 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EXF78822.1 - 2.3e-05 23.6 0.0 5.7e-05 22.3 0.0 1.6 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 EXF78822.1 - 0.00013 21.9 0.2 0.0012 18.7 0.2 2.4 1 1 0 1 1 1 1 NAD(P)H-binding NAD_binding_4 PF07993.12 EXF78822.1 - 0.002 17.4 0.2 0.023 13.9 0.2 2.1 1 1 0 1 1 1 1 Male sterility protein adh_short PF00106.25 EXF78822.1 - 0.074 12.5 1.7 4.4 6.7 0.8 2.8 2 1 0 2 2 2 0 short chain dehydrogenase GDP_Man_Dehyd PF16363.5 EXF78822.1 - 0.08 12.3 0.3 0.91 8.8 0.3 2.1 1 1 0 1 1 1 0 GDP-mannose 4,6 dehydratase CENP-T_C PF15511.6 EXF78823.1 - 2.5e-45 153.0 0.1 4.1e-45 152.3 0.1 1.3 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 EXF78823.1 - 1.2e-08 35.2 0.1 2.2e-08 34.4 0.1 1.3 1 0 0 1 1 1 1 CENP-S protein Histone PF00125.24 EXF78823.1 - 9.2e-05 22.8 0.0 0.00023 21.6 0.0 1.7 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EXF78823.1 - 0.0023 18.2 0.0 0.0041 17.4 0.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone SURF1 PF02104.15 EXF78824.1 - 4.2e-49 167.2 0.1 5.8e-49 166.7 0.1 1.1 1 0 0 1 1 1 1 SURF1 family UBX PF00789.20 EXF78825.1 - 1.8e-10 40.9 0.0 3.1e-10 40.1 0.0 1.4 1 0 0 1 1 1 1 UBX domain Thioredoxin_7 PF13899.6 EXF78825.1 - 0.055 13.7 0.3 0.26 11.5 0.0 2.3 2 0 0 2 2 2 0 Thioredoxin-like TFIIA PF03153.13 EXF78825.1 - 0.15 12.1 6.9 0.2 11.6 6.9 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4834 PF16118.5 EXF78825.1 - 0.54 11.2 2.0 38 5.3 3.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) TMPIT PF07851.13 EXF78825.1 - 7.8 5.6 5.1 11 5.1 5.1 1.1 1 0 0 1 1 1 0 TMPIT-like protein Borrelia_P83 PF05262.11 EXF78825.1 - 8 4.8 16.9 11 4.3 16.9 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein CHCH PF06747.13 EXF78826.1 - 0.00073 19.6 4.9 0.0011 19.0 4.9 1.3 1 0 0 1 1 1 1 CHCH domain Trypan_glycop_C PF10659.9 EXF78826.1 - 0.045 14.1 3.7 0.059 13.8 2.6 1.7 2 0 0 2 2 2 0 Trypanosome variant surface glycoprotein C-terminal domain Kisspeptin PF15152.6 EXF78826.1 - 2.3 9.1 8.2 5.9 7.8 0.2 3.0 2 1 1 3 3 3 0 Kisspeptin Sas10_Utp3 PF04000.15 EXF78827.1 - 2.4e-15 56.9 0.9 2.4e-15 56.9 0.9 1.9 2 0 0 2 2 2 1 Sas10/Utp3/C1D family DUF3619 PF12279.8 EXF78827.1 - 0.2 12.0 1.8 0.43 10.9 1.3 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3619) COG2 PF06148.11 EXF78827.1 - 0.3 11.2 3.4 6.4 6.9 0.0 2.8 1 1 2 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF5302 PF17227.2 EXF78827.1 - 0.91 10.6 6.9 0.57 11.2 4.7 1.7 2 0 0 2 2 2 0 Family of unknown function (DUF5302) ApbA_C PF08546.11 EXF78828.1 - 4.4e-18 65.7 0.0 1.1e-17 64.4 0.0 1.7 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.16 EXF78828.1 - 6.7e-07 29.1 0.0 1.4e-06 28.1 0.0 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA dsDNA_bind PF01984.20 EXF78829.1 - 2.9e-42 143.4 14.9 3.4e-42 143.2 14.9 1.0 1 0 0 1 1 1 1 Double-stranded DNA-binding domain cwf18 PF08315.12 EXF78829.1 - 0.0071 17.0 3.4 0.0091 16.7 3.4 1.2 1 0 0 1 1 1 1 cwf18 pre-mRNA splicing factor K_channel_TID PF07941.11 EXF78829.1 - 0.022 15.2 7.0 0.044 14.2 7.0 1.5 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain Fes1 PF08609.10 EXF78829.1 - 0.044 14.7 2.6 0.094 13.6 2.6 1.7 1 1 0 1 1 1 0 Nucleotide exchange factor Fes1 DUF2973 PF11189.8 EXF78829.1 - 0.2 11.7 0.4 0.43 10.7 0.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2973) Tom5 PF10642.9 EXF78829.1 - 0.42 10.7 2.6 1.3 9.1 2.6 1.9 1 0 0 1 1 1 0 Mitochondrial import receptor subunit or translocase CDT1_C PF16679.5 EXF78829.1 - 1.5 9.3 7.4 2.3 8.7 7.4 1.4 1 1 0 1 1 1 0 DNA replication factor Cdt1 C-terminal domain DUF4670 PF15709.5 EXF78829.1 - 4.5 6.5 17.1 6.1 6.0 17.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4670) Coq4 PF05019.13 EXF78830.1 - 8.8e-93 309.7 0.0 1.1e-92 309.4 0.0 1.1 1 0 0 1 1 1 1 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 SET PF00856.28 EXF78831.1 - 9.7e-10 39.1 0.0 1.4e-09 38.6 0.0 1.2 1 0 0 1 1 1 1 SET domain RRM_1 PF00076.22 EXF78832.1 - 0.00051 19.8 0.0 0.00087 19.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Borrelia_P83 PF05262.11 EXF78832.1 - 0.61 8.5 5.3 0.76 8.2 5.3 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein Prothymosin PF03247.14 EXF78832.1 - 1.6 9.2 14.6 3.7 8.0 14.6 1.5 1 0 0 1 1 1 0 Prothymosin/parathymosin family Zip PF02535.22 EXF78832.1 - 2.9 7.0 4.7 3.6 6.7 4.7 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter SecE PF00584.20 EXF78833.1 - 1e-14 54.2 0.0 1.1e-14 54.0 0.0 1.1 1 0 0 1 1 1 1 SecE/Sec61-gamma subunits of protein translocation complex WD40 PF00400.32 EXF78834.1 - 1.3e-21 76.5 17.8 0.00017 22.3 0.6 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EXF78834.1 - 0.00031 21.0 0.0 0.15 12.4 0.0 3.4 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.16 EXF78834.1 - 0.0021 16.6 4.5 0.26 9.8 0.0 3.9 3 1 1 4 4 4 2 Cytochrome D1 heme domain PD40 PF07676.12 EXF78834.1 - 0.021 14.8 0.3 0.15 12.0 0.0 2.7 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat PTPRCAP PF15713.5 EXF78834.1 - 0.51 10.6 6.1 1.4 9.2 6.1 1.7 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated BUD22 PF09073.10 EXF78834.1 - 1.2 8.4 7.7 1.9 7.8 7.7 1.3 1 0 0 1 1 1 0 BUD22 SDA1 PF05285.12 EXF78834.1 - 1.4 8.2 6.0 2 7.8 6.0 1.2 1 0 0 1 1 1 0 SDA1 UPF0016 PF01169.19 EXF78835.1 - 8.3e-41 138.2 25.0 2.1e-20 72.8 7.2 2.2 2 0 0 2 2 2 2 Uncharacterized protein family UPF0016 UPF0370 PF13980.6 EXF78835.1 - 0.099 12.7 0.1 0.27 11.3 0.1 1.7 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0370) HET PF06985.11 EXF78836.1 - 4.3e-22 79.0 0.0 1.2e-21 77.6 0.0 1.8 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Peptidase_S8 PF00082.22 EXF78838.1 - 8.1e-22 77.8 0.0 1.5e-21 77.0 0.0 1.4 1 0 0 1 1 1 1 Subtilase family NACHT PF05729.12 EXF78839.1 - 1.2e-12 48.0 0.0 2.5e-12 47.0 0.0 1.5 1 0 0 1 1 1 1 NACHT domain Ank_2 PF12796.7 EXF78839.1 - 4.7e-09 36.7 0.0 0.004 17.7 0.0 3.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EXF78839.1 - 2.1e-07 31.3 0.0 0.0025 18.4 0.0 4.6 2 2 2 4 4 4 1 Ankyrin repeats (many copies) Ank PF00023.30 EXF78839.1 - 0.00019 21.7 2.3 7.4 7.2 0.2 5.7 4 1 0 4 4 4 1 Ankyrin repeat AAA_16 PF13191.6 EXF78839.1 - 0.00022 21.7 0.0 0.0011 19.4 0.0 2.2 1 1 0 1 1 1 1 AAA ATPase domain PNP_UDP_1 PF01048.20 EXF78839.1 - 0.00066 19.0 0.0 0.0052 16.1 0.0 2.4 2 1 0 2 2 2 1 Phosphorylase superfamily Ank_5 PF13857.6 EXF78839.1 - 0.0014 18.9 0.2 0.03 14.6 0.0 3.1 3 0 0 3 3 2 1 Ankyrin repeats (many copies) AAA_7 PF12775.7 EXF78839.1 - 0.0018 17.8 0.0 0.0038 16.8 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region TsaE PF02367.17 EXF78839.1 - 0.023 14.7 0.0 0.047 13.7 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Ank_3 PF13606.6 EXF78839.1 - 0.03 14.8 0.4 16 6.4 0.0 4.3 4 0 0 4 4 4 0 Ankyrin repeat Hexokinase_2 PF03727.16 EXF78839.1 - 0.033 13.6 0.2 0.088 12.2 0.0 1.8 2 0 0 2 2 2 0 Hexokinase RNA_helicase PF00910.22 EXF78839.1 - 0.074 13.5 0.0 0.23 11.9 0.0 1.9 1 0 0 1 1 1 0 RNA helicase AAA_22 PF13401.6 EXF78839.1 - 0.09 13.1 0.0 0.25 11.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain zf-Di19 PF05605.12 EXF78839.1 - 0.12 12.7 1.1 37 4.7 0.0 3.4 3 0 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding Cys_Met_Meta_PP PF01053.20 EXF78841.1 - 8.2e-139 462.4 0.0 9.4e-139 462.2 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 EXF78841.1 - 4e-07 29.6 0.0 9.3e-07 28.3 0.0 1.5 2 0 0 2 2 2 1 Aminotransferase class I and II Aminotran_5 PF00266.19 EXF78841.1 - 5.4e-06 25.6 0.1 1.6e-05 24.0 0.0 1.7 2 0 0 2 2 2 1 Aminotransferase class-V Met_gamma_lyase PF06838.11 EXF78841.1 - 8.1e-05 21.3 0.3 0.00028 19.6 0.3 1.7 1 1 0 1 1 1 1 Methionine gamma-lyase DegT_DnrJ_EryC1 PF01041.17 EXF78841.1 - 0.00026 20.4 0.1 0.00098 18.5 0.0 1.8 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family PELOTA_1 PF15608.6 EXF78841.1 - 0.022 14.6 0.8 0.12 12.2 1.0 2.0 1 1 1 2 2 2 0 PELOTA RNA binding domain Serinc PF03348.15 EXF78842.1 - 5.4e-154 513.2 4.7 6.7e-154 512.9 4.7 1.0 1 0 0 1 1 1 1 Serine incorporator (Serinc) MFS_1 PF07690.16 EXF78843.1 - 1.5e-18 66.8 33.8 2.9e-16 59.3 10.1 3.0 2 1 0 2 2 2 2 Major Facilitator Superfamily Nodulin-like PF06813.13 EXF78843.1 - 7.4e-15 55.1 4.2 7.4e-15 55.1 4.2 1.9 2 0 0 2 2 2 1 Nodulin-like PGAP1 PF07819.13 EXF78844.1 - 9.3e-94 313.5 0.0 1.4e-93 312.9 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_6 PF12697.7 EXF78844.1 - 0.0035 18.0 0.1 0.012 16.3 0.1 2.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EXF78844.1 - 0.0073 16.0 0.0 0.016 14.8 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EXF78844.1 - 0.016 14.5 0.0 0.034 13.4 0.0 1.5 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Palm_thioest PF02089.15 EXF78844.1 - 0.036 13.9 0.0 0.061 13.2 0.0 1.3 1 0 0 1 1 1 0 Palmitoyl protein thioesterase DUF676 PF05057.14 EXF78844.1 - 0.077 12.5 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 Putative serine esterase (DUF676) UPF0060 PF02694.15 EXF78844.1 - 0.35 11.1 0.0 0.35 11.1 0.0 3.1 3 0 0 3 3 3 0 Uncharacterised BCR, YnfA/UPF0060 family MutL_C PF08676.11 EXF78845.1 - 2.4e-21 76.0 0.0 5.1e-21 75.0 0.0 1.5 1 0 0 1 1 1 1 MutL C terminal dimerisation domain DNA_mis_repair PF01119.19 EXF78845.1 - 5.5e-20 71.2 0.0 1.4e-19 69.9 0.0 1.7 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 EXF78845.1 - 6.9e-12 45.4 0.1 2.1e-11 43.8 0.1 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 EXF78845.1 - 1.8e-06 28.4 0.1 5.5e-06 26.9 0.1 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Pyr_redox_2 PF07992.14 EXF78847.1 - 6.1e-09 35.5 0.2 1.2e-06 28.0 0.0 2.9 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EXF78847.1 - 0.11 12.7 0.0 0.8 10.0 0.0 2.3 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Asp_Glu_race PF01177.22 EXF78847.1 - 0.21 11.4 0.0 0.35 10.7 0.0 1.2 1 0 0 1 1 1 0 Asp/Glu/Hydantoin racemase ETF PF01012.21 EXF78848.1 - 1.8e-43 148.5 1.5 3.1e-43 147.8 1.5 1.3 1 0 0 1 1 1 1 Electron transfer flavoprotein domain ETF_alpha PF00766.19 EXF78848.1 - 4.6e-34 116.3 0.5 1.6e-33 114.6 0.5 2.0 1 0 0 1 1 1 1 Electron transfer flavoprotein FAD-binding domain SWIRM PF04433.17 EXF78849.1 - 3.6e-31 107.4 0.1 7.5e-31 106.3 0.1 1.6 1 0 0 1 1 1 1 SWIRM domain SWIRM-assoc_1 PF16495.5 EXF78849.1 - 9.5e-30 102.4 4.7 2.1e-29 101.3 4.7 1.6 1 0 0 1 1 1 1 SWIRM-associated region 1 Myb_DNA-binding PF00249.31 EXF78849.1 - 5.3e-10 39.3 0.0 1.2e-09 38.3 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EXF78849.1 - 6.7e-06 26.3 0.0 1.5e-05 25.2 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain ZZ PF00569.17 EXF78849.1 - 0.0063 16.3 3.4 0.013 15.3 3.4 1.5 1 0 0 1 1 1 1 Zinc finger, ZZ type DUF3439 PF11921.8 EXF78849.1 - 0.1 12.6 0.8 0.21 11.5 0.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) SANT_DAMP1_like PF16282.5 EXF78849.1 - 0.15 12.3 0.0 0.3 11.3 0.0 1.4 1 0 0 1 1 1 0 SANT/Myb-like domain of DAMP1 Carn_acyltransf PF00755.20 EXF78850.1 - 2e-200 667.4 0.0 2.3e-200 667.2 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase CAP_N PF01213.19 EXF78851.1 - 4.1e-85 286.0 1.3 4.1e-85 286.0 1.3 1.5 1 1 0 1 1 1 1 Adenylate cyclase associated (CAP) N terminal CAP_C PF08603.11 EXF78851.1 - 1.3e-56 190.6 4.4 1.6e-56 190.2 4.4 1.1 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal TBCC PF07986.12 EXF78851.1 - 0.3 10.8 1.8 0.83 9.4 1.2 1.6 1 1 0 1 1 1 0 Tubulin binding cofactor C NDT80_PhoG PF05224.12 EXF78852.1 - 2.7e-34 119.0 0.0 1.7e-33 116.4 0.0 2.0 2 0 0 2 2 2 1 NDT80 / PhoG like DNA-binding family DUF2011 PF09428.10 EXF78853.1 - 1.1e-21 76.8 0.0 2.8e-21 75.6 0.0 1.7 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF2011) GTP_EFTU PF00009.27 EXF78854.1 - 4.6e-57 192.7 0.2 6.3e-57 192.3 0.2 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EXF78854.1 - 1.9e-26 92.6 0.1 4.8e-26 91.3 0.0 1.8 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EXF78854.1 - 1.6e-15 57.2 2.3 1.6e-15 57.2 2.3 1.9 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EXF78854.1 - 1.4e-05 25.1 0.1 2.8e-05 24.2 0.1 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EXF78854.1 - 0.00095 19.1 0.0 0.003 17.5 0.0 1.9 2 0 0 2 2 2 1 RsgA GTPase cobW PF02492.19 EXF78854.1 - 0.023 14.3 0.3 0.14 11.7 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain PduV-EutP PF10662.9 EXF78854.1 - 0.085 12.6 0.2 15 5.3 0.0 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Ribosomal_S14 PF00253.21 EXF78855.1 - 4.9e-16 58.2 3.5 5.4e-16 58.1 3.5 1.0 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e ZZ PF00569.17 EXF78855.1 - 0.17 11.7 4.3 2 8.3 4.3 2.1 1 1 0 1 1 1 0 Zinc finger, ZZ type Thioredoxin PF00085.20 EXF78856.1 - 4.3e-57 190.5 0.0 2.1e-29 101.5 0.0 2.3 2 0 0 2 2 2 2 Thioredoxin ERp29 PF07749.12 EXF78856.1 - 3.9e-27 95.0 2.0 6.9e-27 94.2 0.9 2.0 2 0 0 2 2 2 1 Endoplasmic reticulum protein ERp29, C-terminal domain Thioredoxin_2 PF13098.6 EXF78856.1 - 7.9e-15 55.2 0.0 4e-07 30.5 0.0 3.0 2 0 0 2 2 2 2 Thioredoxin-like domain OST3_OST6 PF04756.13 EXF78856.1 - 1.8e-13 50.5 0.0 3.4e-06 26.6 0.0 2.1 1 1 1 2 2 2 2 OST3 / OST6 family, transporter family Thioredoxin_7 PF13899.6 EXF78856.1 - 6.2e-08 32.7 0.7 0.0024 18.0 0.0 2.8 3 0 0 3 3 3 2 Thioredoxin-like AhpC-TSA PF00578.21 EXF78856.1 - 1.8e-07 31.1 0.0 0.0016 18.4 0.0 2.4 2 0 0 2 2 2 2 AhpC/TSA family Thioredoxin_8 PF13905.6 EXF78856.1 - 6.2e-07 29.7 0.0 0.0024 18.2 0.0 3.1 2 1 1 3 3 3 2 Thioredoxin-like TraF PF13728.6 EXF78856.1 - 7.5e-05 22.6 0.0 0.39 10.5 0.0 2.5 2 0 0 2 2 2 2 F plasmid transfer operon protein Redoxin PF08534.10 EXF78856.1 - 8.9e-05 22.2 0.1 0.024 14.3 0.0 2.4 2 0 0 2 2 2 2 Redoxin HyaE PF07449.11 EXF78856.1 - 0.0006 19.8 0.0 0.022 14.7 0.0 2.5 2 0 0 2 2 2 1 Hydrogenase-1 expression protein HyaE Thioredoxin_9 PF14595.6 EXF78856.1 - 0.0011 18.8 0.0 0.67 9.7 0.0 2.4 2 0 0 2 2 2 2 Thioredoxin ERp29_N PF07912.13 EXF78856.1 - 0.0014 18.8 0.6 0.0044 17.2 0.0 2.1 3 0 0 3 3 3 1 ERp29, N-terminal domain Thioredoxin_4 PF13462.6 EXF78856.1 - 0.013 15.7 1.1 13 5.9 0.1 3.7 3 2 1 4 4 4 0 Thioredoxin Glutaredoxin PF00462.24 EXF78856.1 - 0.013 15.7 0.2 3.6 7.9 0.0 2.9 2 1 0 2 2 2 0 Glutaredoxin HSBP1 PF06825.12 EXF78857.1 - 6.3e-16 58.0 0.1 7.3e-16 57.8 0.1 1.1 1 0 0 1 1 1 1 Heat shock factor binding protein 1 Baculo_PEP_C PF04513.12 EXF78857.1 - 0.013 15.6 0.1 0.014 15.4 0.1 1.1 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DASH_Spc19 PF08287.11 EXF78857.1 - 0.031 14.2 0.0 0.039 13.8 0.0 1.1 1 0 0 1 1 1 0 Spc19 CheX PF13690.6 EXF78857.1 - 0.064 13.4 0.1 0.074 13.2 0.1 1.2 1 0 0 1 1 1 0 Chemotaxis phosphatase CheX CLZ PF16526.5 EXF78857.1 - 0.071 13.5 0.0 0.085 13.2 0.0 1.1 1 0 0 1 1 1 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF1664 PF07889.12 EXF78857.1 - 0.13 12.3 0.0 0.14 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) zf-rbx1 PF12678.7 EXF78858.1 - 4.7e-10 39.6 0.6 9e-10 38.7 0.6 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 EXF78858.1 - 6e-08 32.9 2.2 6e-08 32.9 2.2 2.1 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.25 EXF78858.1 - 6.9e-07 29.0 0.5 1.1e-06 28.3 0.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EXF78858.1 - 1.7e-06 27.8 1.4 3.8e-06 26.7 1.4 1.6 1 1 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EXF78858.1 - 4.3e-06 26.6 1.6 5.2e-05 23.2 0.1 3.0 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EXF78858.1 - 7.9e-06 25.6 6.2 2.3e-05 24.1 1.8 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EXF78858.1 - 2.3e-05 24.2 1.1 4.8e-05 23.1 1.1 1.5 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 EXF78858.1 - 0.00018 21.3 1.2 0.00018 21.3 1.2 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) DUF2921 PF11145.8 EXF78858.1 - 0.001 17.0 1.0 0.0015 16.5 1.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2921) Zn_ribbon_17 PF17120.5 EXF78858.1 - 0.0053 16.3 0.7 0.013 15.1 0.7 1.6 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-RING_11 PF17123.5 EXF78858.1 - 0.0076 16.0 0.6 0.0076 16.0 0.6 3.2 3 0 0 3 3 3 1 RING-like zinc finger zf-ANAPC11 PF12861.7 EXF78858.1 - 0.018 15.1 0.9 0.047 13.8 0.9 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Glyco_hydro_61 PF03443.14 EXF78860.1 - 3.1e-64 216.7 0.5 3.7e-64 216.4 0.5 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 NPCBM_assoc PF10633.9 EXF78860.1 - 0.016 15.4 0.2 1.2 9.4 0.0 2.6 2 1 0 2 2 2 0 NPCBM-associated, NEW3 domain of alpha-galactosidase SHIPPO-rpt PF07004.12 EXF78860.1 - 1.1 10.2 4.2 25 6.0 2.4 3.1 2 0 0 2 2 2 0 Sperm-tail PG-rich repeat SprB PF13573.6 EXF78860.1 - 1.3 8.8 9.2 13 5.7 0.2 3.7 3 1 0 3 3 3 0 SprB repeat Zn_clus PF00172.18 EXF78861.1 - 8.1e-07 29.1 7.9 1.9e-06 27.9 7.9 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF1256 PF06866.11 EXF78862.1 - 0.094 12.1 0.3 6.3 6.2 0.0 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF1256) Sporozoite_P67 PF05642.11 EXF78862.1 - 0.11 10.6 1.0 0.13 10.3 1.0 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen BUD22 PF09073.10 EXF78862.1 - 0.62 9.3 3.9 0.79 9.0 3.9 1.1 1 0 0 1 1 1 0 BUD22 NOA36 PF06524.12 EXF78862.1 - 9.8 5.4 7.4 17 4.6 7.4 1.3 1 0 0 1 1 1 0 NOA36 protein Pkinase PF00069.25 EXF78863.1 - 3.1e-44 151.3 0.0 2.1e-43 148.6 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF78863.1 - 5.8e-31 107.7 0.0 8.4e-31 107.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EXF78863.1 - 0.0043 16.4 0.0 0.0063 15.9 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EXF78863.1 - 0.0088 15.4 0.0 0.085 12.2 0.0 2.1 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family adh_short_C2 PF13561.6 EXF78864.1 - 2.2e-50 171.4 0.0 2.8e-50 171.1 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF78864.1 - 1.4e-43 148.7 0.1 1.6e-43 148.5 0.1 1.0 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EXF78864.1 - 6.6e-06 26.1 0.1 9.8e-06 25.6 0.1 1.2 1 0 0 1 1 1 1 KR domain Ldh_1_N PF00056.23 EXF78864.1 - 0.012 15.6 0.0 0.021 14.9 0.0 1.3 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain HHH_5 PF14520.6 EXF78864.1 - 0.049 14.2 0.1 0.1 13.2 0.1 1.5 1 0 0 1 1 1 0 Helix-hairpin-helix domain Fungal_trans PF04082.18 EXF78865.1 - 1.5e-20 73.3 0.0 2.7e-20 72.5 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain CTP_transf_like PF01467.26 EXF78866.1 - 0.00026 21.2 0.0 0.00068 19.8 0.0 1.8 1 1 0 1 1 1 1 Cytidylyltransferase-like F-box-like PF12937.7 EXF78867.1 - 4.7e-05 23.2 0.2 4.7e-05 23.2 0.2 2.1 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EXF78867.1 - 8.3e-05 22.4 0.1 0.00026 20.8 0.1 1.9 1 0 0 1 1 1 1 F-box domain LRR_6 PF13516.6 EXF78867.1 - 0.15 12.2 0.7 2.5 8.4 0.6 3.0 3 0 0 3 3 3 0 Leucine Rich repeat Acyl-CoA_dh_1 PF00441.24 EXF78869.1 - 5.9e-25 88.2 0.6 9.7e-25 87.5 0.6 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 EXF78869.1 - 1.5e-13 51.4 0.4 5.6e-13 49.5 0.0 2.1 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 EXF78869.1 - 7.5e-09 36.0 0.0 1.3e-08 35.2 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 EXF78869.1 - 3.6e-08 33.5 0.0 5.8e-08 32.8 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Aldedh PF00171.22 EXF78870.1 - 6e-158 526.1 0.0 6.9e-158 525.9 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 EXF78870.1 - 0.096 12.1 0.0 8.2 5.8 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1487) adh_short_C2 PF13561.6 EXF78871.1 - 8.4e-42 143.3 0.0 1.1e-41 143.0 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF78871.1 - 1.6e-35 122.3 0.1 2.6e-35 121.6 0.1 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EXF78871.1 - 4.2e-07 30.0 0.1 6.8e-07 29.4 0.1 1.3 1 0 0 1 1 1 1 KR domain AMP-binding PF00501.28 EXF78872.1 - 4.2e-95 318.8 0.0 5.4e-95 318.5 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EXF78872.1 - 8.2e-12 45.9 1.3 2.1e-11 44.7 1.3 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain FMO-like PF00743.19 EXF78873.1 - 1.7e-13 49.8 0.0 4.6e-10 38.5 0.0 2.9 2 2 0 2 2 2 2 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.6 EXF78873.1 - 1.3e-10 41.3 0.0 3.6e-10 39.9 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 EXF78873.1 - 2.6e-06 26.9 0.0 3e-05 23.4 0.0 2.4 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EXF78873.1 - 3.1e-06 26.6 0.0 0.0046 16.2 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EXF78873.1 - 0.0032 16.7 0.0 2.4 7.2 0.0 3.0 3 1 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 EXF78873.1 - 0.0087 16.1 0.0 0.064 13.2 0.0 2.4 3 0 0 3 3 3 1 FAD-NAD(P)-binding DAO PF01266.24 EXF78873.1 - 0.056 13.0 0.0 3.5 7.1 0.0 2.9 2 1 1 3 3 3 0 FAD dependent oxidoreductase Apt1 PF10351.9 EXF78874.1 - 1.4 7.7 5.8 1.5 7.6 5.8 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Macoilin PF09726.9 EXF78874.1 - 2.2 6.7 11.4 2.8 6.4 11.4 1.2 1 0 0 1 1 1 0 Macoilin family SOBP PF15279.6 EXF78874.1 - 5 7.6 26.8 6.8 7.2 26.8 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein Presenilin PF01080.17 EXF78874.1 - 8 5.1 10.8 12 4.5 10.8 1.4 1 0 0 1 1 1 0 Presenilin ExoD PF06055.12 EXF78875.1 - 0.059 12.8 0.2 0.073 12.4 0.2 1.3 1 1 0 1 1 1 0 Exopolysaccharide synthesis, ExoD LysM PF01476.20 EXF78876.1 - 8.3e-09 35.4 0.0 1.3e-08 34.7 0.0 1.3 1 0 0 1 1 1 1 LysM domain Actino_peptide PF14408.6 EXF78876.1 - 0.031 14.4 0.1 0.062 13.4 0.1 1.4 1 0 0 1 1 1 0 Ribosomally synthesised peptide in actinomycetes DUF903 PF06004.12 EXF78876.1 - 0.086 12.7 1.0 0.17 11.8 1.0 1.4 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF903) Cellulase PF00150.18 EXF78877.1 - 8.2e-21 74.7 2.6 1.2e-20 74.1 2.6 1.2 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) CBM_1 PF00734.18 EXF78877.1 - 2.1e-13 50.0 15.2 9.2e-13 47.9 15.2 2.2 1 0 0 1 1 1 1 Fungal cellulose binding domain Glyco_hydro_2_C PF02836.17 EXF78877.1 - 3.7e-05 23.0 0.1 5.6e-05 22.4 0.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain DUF4038 PF13204.6 EXF78877.1 - 9.8e-05 22.1 0.2 0.00015 21.6 0.2 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF4038) Glyco_hydro_42 PF02449.15 EXF78877.1 - 0.0006 19.3 0.2 0.0014 18.1 0.1 1.5 2 0 0 2 2 2 1 Beta-galactosidase adh_short PF00106.25 EXF78878.1 - 8e-32 110.3 0.1 9.7e-32 110.0 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF78878.1 - 1.5e-21 77.1 0.3 3.5e-21 75.8 0.3 1.6 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF78878.1 - 5.2e-09 36.3 0.0 8.8e-09 35.5 0.0 1.3 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EXF78878.1 - 1.1e-08 34.6 0.0 1.6e-08 34.0 0.0 1.4 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.21 EXF78878.1 - 0.0051 16.3 0.0 0.0086 15.6 0.0 1.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Glyco_tran_WecB PF03808.13 EXF78878.1 - 0.038 14.0 0.0 0.22 11.5 0.0 2.0 2 0 0 2 2 2 0 Glycosyl transferase WecB/TagA/CpsF family Glyco_hydro_43 PF04616.14 EXF78879.1 - 8.7e-53 179.5 1.5 1.3e-52 178.9 1.5 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 GH43_C2 PF17851.1 EXF78879.1 - 9.1e-27 94.1 0.0 1.4e-26 93.5 0.0 1.3 1 0 0 1 1 1 1 Beta xylosidase C-terminal Concanavalin A-like domain DUF5005 PF16396.5 EXF78879.1 - 0.017 13.8 0.1 0.33 9.6 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF5005) GFA PF04828.14 EXF78880.1 - 2.3e-21 75.9 0.2 3.2e-21 75.5 0.2 1.2 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme Fungal_trans_2 PF11951.8 EXF78881.1 - 3.3e-05 22.9 0.0 0.00041 19.3 0.0 2.0 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF78881.1 - 0.0036 17.4 9.3 0.0078 16.3 9.3 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain adh_short_C2 PF13561.6 EXF78882.1 - 1.5e-54 185.0 0.5 2e-54 184.6 0.5 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF78882.1 - 1.4e-45 155.2 1.6 1.8e-45 154.8 1.6 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EXF78882.1 - 1.4e-13 51.1 1.0 2e-13 50.7 1.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EXF78882.1 - 0.0022 17.5 0.2 0.0058 16.1 0.2 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EXF78882.1 - 0.083 12.3 0.0 0.14 11.5 0.0 1.4 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase AA_permease_2 PF13520.6 EXF78884.1 - 6e-42 144.0 49.6 7.6e-42 143.6 49.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EXF78884.1 - 7.5e-21 74.3 42.7 1.3e-20 73.4 42.7 1.4 1 1 0 1 1 1 1 Amino acid permease HET PF06985.11 EXF78886.1 - 1.9e-21 77.0 0.0 4.5e-21 75.7 0.0 1.7 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) DUF2007 PF09413.10 EXF78889.1 - 0.058 13.6 0.0 0.1 12.7 0.0 1.4 1 0 0 1 1 1 0 Putative prokaryotic signal transducing protein SepRS_C PF18006.1 EXF78889.1 - 0.13 12.3 0.2 0.47 10.6 0.0 1.9 2 0 0 2 2 2 0 O-phosphoseryl-tRNA synthetase C-terminal domain NGP1NT PF08153.12 EXF78891.1 - 4.9e-50 169.0 0.0 8.4e-50 168.3 0.0 1.4 1 0 0 1 1 1 1 NGP1NT (NUC091) domain MMR_HSR1 PF01926.23 EXF78891.1 - 6.1e-18 65.0 0.0 7e-14 51.9 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase FeoB_N PF02421.18 EXF78891.1 - 5e-06 26.1 0.1 2.5e-05 23.9 0.1 1.9 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EXF78891.1 - 2.9e-05 24.1 0.0 8.4e-05 22.5 0.0 1.8 2 1 0 2 2 2 1 RsgA GTPase Arf PF00025.21 EXF78891.1 - 0.001 18.5 0.0 0.17 11.3 0.0 2.2 2 0 0 2 2 2 2 ADP-ribosylation factor family GTP_EFTU PF00009.27 EXF78891.1 - 0.0027 17.3 0.0 0.25 10.9 0.0 2.8 1 1 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 EXF78891.1 - 0.057 13.8 0.0 0.15 12.4 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain Roc PF08477.13 EXF78891.1 - 0.066 13.4 0.0 2.7 8.2 0.0 2.5 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Dynamin_N PF00350.23 EXF78891.1 - 0.068 13.2 0.1 3.9 7.5 0.1 3.0 2 1 1 3 3 3 0 Dynamin family ABC2_membrane PF01061.24 EXF78893.1 - 5.7e-39 133.7 19.7 1.2e-38 132.6 19.7 1.6 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 EXF78893.1 - 8.9e-25 87.8 0.0 2e-24 86.6 0.0 1.6 1 0 0 1 1 1 1 ABC transporter ABC2_membrane_3 PF12698.7 EXF78893.1 - 9.1e-08 31.6 24.2 9.1e-08 31.6 24.2 2.3 2 1 1 3 3 3 1 ABC-2 family transporter protein AAA_21 PF13304.6 EXF78893.1 - 4.5e-05 23.4 0.0 0.25 11.1 0.1 2.3 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EXF78893.1 - 0.0045 16.7 0.0 0.01 15.5 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_25 PF13481.6 EXF78893.1 - 0.0092 15.6 0.0 0.022 14.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 EXF78893.1 - 0.012 15.5 0.0 0.025 14.5 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase AAA_18 PF13238.6 EXF78893.1 - 0.014 16.0 0.0 0.029 14.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain SMC_N PF02463.19 EXF78893.1 - 0.032 13.7 0.0 0.29 10.5 0.0 2.2 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain NACHT PF05729.12 EXF78893.1 - 0.054 13.4 0.0 0.1 12.5 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA_22 PF13401.6 EXF78893.1 - 0.083 13.2 0.0 0.18 12.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EXF78893.1 - 0.085 13.2 0.0 0.16 12.3 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_23 PF13476.6 EXF78893.1 - 0.091 13.2 0.0 0.21 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain Aminotran_1_2 PF00155.21 EXF78894.1 - 1.5e-35 123.1 0.0 2.6e-35 122.3 0.0 1.4 1 1 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.7 EXF78894.1 - 1.5e-07 30.6 0.0 1.9e-07 30.2 0.0 1.2 1 0 0 1 1 1 1 Alanine-glyoxylate amino-transferase Cys_Met_Meta_PP PF01053.20 EXF78894.1 - 0.00014 20.5 0.0 0.00022 19.9 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 EXF78894.1 - 0.0003 19.9 0.0 0.00051 19.1 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Xrn1_D3 PF18194.1 EXF78894.1 - 0.031 14.4 0.0 6 7.0 0.0 2.4 2 0 0 2 2 2 0 Exoribonuclease 1 Domain-3 CR6_interact PF10147.9 EXF78895.1 - 0.0033 17.2 2.1 0.0069 16.1 2.1 1.6 1 0 0 1 1 1 1 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 RCR PF12273.8 EXF78895.1 - 0.032 14.9 0.1 0.032 14.9 0.1 2.9 2 2 0 2 2 2 0 Chitin synthesis regulation, resistance to Congo red EphA2_TM PF14575.6 EXF78895.1 - 0.14 13.1 0.0 0.4 11.6 0.0 1.9 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain SARAF PF06682.12 EXF78895.1 - 0.14 11.7 1.3 0.87 9.2 0.0 2.3 2 0 0 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis DUF4519 PF15012.6 EXF78895.1 - 5.6 7.2 5.2 2.6 8.3 0.3 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4519) Ribosomal_S8 PF00410.19 EXF78897.1 - 1.7e-12 47.3 0.0 1.8e-11 44.1 0.0 2.0 1 1 0 1 1 1 1 Ribosomal protein S8 Iso_dh PF00180.20 EXF78899.1 - 3.1e-98 329.1 0.0 5.4e-98 328.4 0.0 1.3 1 1 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase CHASE3 PF05227.13 EXF78899.1 - 0.033 14.1 0.3 0.081 12.8 0.4 1.5 1 1 0 1 1 1 0 CHASE3 domain SET PF00856.28 EXF78900.1 - 6.2e-07 30.0 0.0 3.3e-06 27.6 0.0 2.0 1 1 0 1 1 1 1 SET domain zf-C2HCIx2C PF10782.9 EXF78901.1 - 0.086 12.8 0.2 5.5 7.0 0.1 2.5 2 0 0 2 2 2 0 Zinc-finger MFS_1 PF07690.16 EXF78902.1 - 5e-22 78.3 30.4 5e-22 78.3 30.4 2.5 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 EXF78902.1 - 1 7.5 6.3 8.5 4.5 5.1 2.6 2 1 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Tir_receptor_C PF07489.11 EXF78902.1 - 1.8 8.5 5.1 4.3 7.2 0.0 2.8 3 0 0 3 3 3 0 Translocated intimin receptor (Tir) C-terminus DUF4282 PF14110.6 EXF78903.1 - 0.029 15.1 0.2 0.029 15.1 0.2 3.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4282) DUF2393 PF09624.10 EXF78903.1 - 0.54 10.3 2.5 0.88 9.6 0.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2393) Methyltransf_22 PF13383.6 EXF78904.1 - 3.6e-18 66.1 0.0 4.9e-18 65.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_21 PF05050.12 EXF78904.1 - 9.8e-08 32.2 0.0 1.3e-07 31.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase FkbM domain BTRD1 PF17660.1 EXF78904.1 - 0.048 13.5 0.0 0.09 12.6 0.0 1.4 1 0 0 1 1 1 0 Bacterial tandem repeat domain 1 FMN_red PF03358.15 EXF78905.1 - 2.6e-07 30.5 0.0 3.9e-07 29.9 0.0 1.2 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 EXF78905.1 - 7e-05 22.6 0.0 9.4e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin-like fold Flavodoxin_1 PF00258.25 EXF78905.1 - 7.6e-05 23.0 0.1 0.015 15.5 0.1 2.2 1 1 1 2 2 2 2 Flavodoxin Flavodoxin_5 PF12724.7 EXF78905.1 - 0.0021 18.3 0.0 0.046 14.0 0.0 2.2 1 1 1 2 2 2 1 Flavodoxin domain Ribosomal_60s PF00428.19 EXF78905.1 - 0.086 13.4 5.5 0.19 12.3 5.5 1.6 1 0 0 1 1 1 0 60s Acidic ribosomal protein Sulfotransfer_4 PF17784.1 EXF78906.1 - 1.6e-51 175.2 0.0 4.4e-51 173.7 0.0 1.6 1 1 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 EXF78906.1 - 0.0001 22.8 0.5 0.0012 19.2 0.5 2.1 1 1 0 1 1 1 1 Sulfotransferase family MFS_1 PF07690.16 EXF78907.1 - 3.9e-26 91.8 58.9 3.4e-21 75.6 35.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF3328 PF11807.8 EXF78908.1 - 4.1e-21 75.8 0.0 5.8e-21 75.3 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) GTP_EFTU PF00009.27 EXF78909.1 - 3.9e-59 199.5 0.4 6.7e-59 198.7 0.4 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_II PF14492.6 EXF78909.1 - 8e-33 112.4 0.0 1.7e-32 111.4 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_IV PF03764.18 EXF78909.1 - 1.1e-30 105.9 0.0 2.2e-30 104.9 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_C PF00679.24 EXF78909.1 - 1.2e-22 79.7 0.0 2.6e-22 78.7 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 EXF78909.1 - 6.1e-14 52.2 0.0 1.4e-13 51.0 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RF3_C PF16658.5 EXF78909.1 - 1.3e-07 31.5 0.0 3.1e-07 30.3 0.0 1.6 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain DUF442 PF04273.13 EXF78909.1 - 0.035 14.2 0.1 1.5 8.9 0.0 3.2 3 0 0 3 3 3 0 Putative phosphatase (DUF442) MMR_HSR1 PF01926.23 EXF78909.1 - 0.086 12.9 0.1 0.21 11.7 0.1 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase Exo_endo_phos PF03372.23 EXF78912.1 - 3.5e-07 30.0 0.0 5.9e-07 29.2 0.0 1.4 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 EXF78912.1 - 0.12 12.2 0.0 0.54 10.1 0.0 2.1 1 1 0 1 1 1 0 Endonuclease-reverse transcriptase Mito_carr PF00153.27 EXF78915.1 - 1.7e-53 178.5 7.2 3.2e-21 75.0 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Fungal_trans PF04082.18 EXF78916.1 - 4.2e-22 78.4 0.3 7.7e-22 77.6 0.3 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain PGF-CTERM PF18204.1 EXF78917.1 - 1.9 8.6 4.4 3.7 7.6 4.4 1.5 1 0 0 1 1 1 0 PGF-CTERM motif DUF805 PF05656.14 EXF78918.1 - 0.00053 20.4 1.5 0.00083 19.7 1.5 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF805) DHHC PF01529.20 EXF78918.1 - 0.9 9.6 5.8 2.4 8.3 0.6 2.2 2 0 0 2 2 2 0 DHHC palmitoyltransferase Glyco_hydro_12 PF01670.16 EXF78919.1 - 1.9e-49 168.6 1.9 2.2e-49 168.4 1.9 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 12 Ank_2 PF12796.7 EXF78920.1 - 6.2e-54 180.5 13.9 2.4e-12 47.3 0.7 11.3 9 2 3 12 12 12 8 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EXF78920.1 - 1.5e-38 130.7 12.8 5.3e-08 33.2 0.0 11.9 11 2 2 13 13 13 5 Ankyrin repeats (many copies) Ank PF00023.30 EXF78920.1 - 1.1e-26 92.1 17.8 0.00056 20.2 0.0 12.5 12 1 0 12 12 12 6 Ankyrin repeat Ank_3 PF13606.6 EXF78920.1 - 2.5e-24 82.7 16.8 0.016 15.7 0.0 14.2 14 0 0 14 14 14 5 Ankyrin repeat Ank_5 PF13857.6 EXF78920.1 - 5.2e-22 77.6 17.1 0.00014 22.1 0.0 10.9 9 4 4 13 13 13 5 Ankyrin repeats (many copies) Transferase PF02458.15 EXF78920.1 - 7.8e-11 41.3 0.0 1.5e-10 40.3 0.0 1.4 1 0 0 1 1 1 1 Transferase family NAPRTase_N PF17767.1 EXF78920.1 - 0.037 14.4 0.1 1.6 9.1 0.0 2.6 2 0 0 2 2 2 0 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain Mito_carr PF00153.27 EXF78921.1 - 5.3e-53 176.9 4.1 2e-18 66.1 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Phage_Coat_B PF05356.11 EXF78921.1 - 0.058 13.3 1.5 2.4 8.1 0.0 3.1 3 1 0 3 3 3 0 Phage Coat protein B FA_hydroxylase PF04116.13 EXF78922.1 - 1.4e-07 31.9 10.8 4.6e-07 30.2 10.8 1.8 1 1 0 1 1 1 1 Fatty acid hydroxylase superfamily p450 PF00067.22 EXF78923.1 - 1.5e-61 208.6 0.0 2e-61 208.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 2OG-FeII_Oxy PF03171.20 EXF78924.1 - 1.2e-18 67.4 0.0 2.1e-18 66.7 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 EXF78924.1 - 2.3e-12 47.7 0.0 3.8e-12 47.0 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal Transp_cyt_pur PF02133.15 EXF78925.1 - 1.8e-92 310.4 29.3 2.1e-92 310.2 29.3 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin DUF983 PF06170.12 EXF78925.1 - 3.6 8.1 14.4 0.087 13.2 2.2 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF983) Asp_Glu_race PF01177.22 EXF78926.1 - 7e-10 39.1 0.2 4.1e-09 36.6 0.2 1.9 1 1 0 1 1 1 1 Asp/Glu/Hydantoin racemase Zn_clus PF00172.18 EXF78927.1 - 0.00017 21.7 6.4 0.0005 20.1 6.4 1.8 1 1 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EXF78927.1 - 0.0044 16.1 0.4 0.0065 15.5 0.4 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Pyr_redox_2 PF07992.14 EXF78928.1 - 5.6e-50 170.2 1.2 6.6e-50 170.0 1.2 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EXF78928.1 - 5.5e-19 68.5 0.5 1.8e-17 63.6 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EXF78928.1 - 1.2e-18 67.4 1.2 1.4e-16 60.8 0.4 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.6 EXF78928.1 - 1.4e-06 28.7 0.1 0.00038 20.9 0.0 2.5 2 1 0 2 2 2 1 Putative NAD(P)-binding Thi4 PF01946.17 EXF78928.1 - 4.2e-05 22.9 0.2 0.00063 19.1 0.1 2.3 2 0 0 2 2 2 1 Thi4 family DAO PF01266.24 EXF78928.1 - 4.5e-05 23.2 1.3 2.4 7.6 0.0 3.3 3 0 0 3 3 3 3 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EXF78928.1 - 0.00014 22.1 0.6 0.042 14.1 0.0 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 EXF78928.1 - 0.00024 20.4 0.4 0.017 14.3 0.1 3.2 2 1 1 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) GIDA PF01134.22 EXF78928.1 - 0.00053 19.2 5.3 0.48 9.4 0.5 3.9 3 1 1 4 4 4 1 Glucose inhibited division protein A Shikimate_DH PF01488.20 EXF78928.1 - 0.00075 19.6 0.6 0.68 10.0 0.1 3.0 2 1 1 3 3 3 1 Shikimate / quinate 5-dehydrogenase FAD_binding_2 PF00890.24 EXF78928.1 - 0.0096 15.0 7.7 0.25 10.4 0.5 3.4 3 1 0 4 4 4 2 FAD binding domain Trp_halogenase PF04820.14 EXF78928.1 - 0.024 13.5 0.2 0.47 9.2 0.0 2.3 3 0 0 3 3 3 0 Tryptophan halogenase FAD_binding_3 PF01494.19 EXF78928.1 - 0.026 13.8 1.3 2.7 7.1 0.0 2.9 2 1 1 3 3 3 0 FAD binding domain Attacin_N PF03768.15 EXF78928.1 - 0.027 14.6 0.0 0.074 13.2 0.0 1.8 1 0 0 1 1 1 0 Attacin, N-terminal region FAD_oxidored PF12831.7 EXF78928.1 - 0.027 13.8 1.1 0.031 13.6 0.1 1.6 2 0 0 2 2 2 0 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EXF78928.1 - 0.059 13.4 0.0 3.4 7.6 0.0 2.7 2 0 0 2 2 2 0 FAD-NAD(P)-binding HI0933_like PF03486.14 EXF78928.1 - 0.11 11.2 1.2 2.3 6.8 0.1 2.9 2 1 1 3 3 3 0 HI0933-like protein PAN_1 PF00024.26 EXF78929.1 - 0.062 13.3 0.0 0.16 11.9 0.0 1.7 1 0 0 1 1 1 0 PAN domain DUF3040 PF11239.8 EXF78929.1 - 0.12 12.6 1.1 0.25 11.6 1.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) Pilin_N PF07790.11 EXF78929.1 - 0.45 11.5 3.9 1.3 10.0 3.9 1.8 1 1 0 1 1 1 0 Archaeal Type IV pilin, N-terminal DUF4054 PF13262.6 EXF78929.1 - 4.2 7.5 7.4 20 5.3 0.0 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF4054) Mid2 PF04478.12 EXF78930.1 - 0.069 13.0 0.1 0.12 12.2 0.1 1.4 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor SKG6 PF08693.10 EXF78930.1 - 0.07 12.5 0.4 0.07 12.5 0.4 2.2 2 0 0 2 2 2 0 Transmembrane alpha-helix domain CcmD PF04995.14 EXF78930.1 - 0.13 12.4 0.9 0.29 11.2 0.9 1.5 1 0 0 1 1 1 0 Heme exporter protein D (CcmD) ELO PF01151.18 EXF78931.1 - 2.6e-62 210.6 15.1 3.4e-62 210.2 15.1 1.1 1 0 0 1 1 1 1 GNS1/SUR4 family PsbX PF06596.11 EXF78931.1 - 1.9 8.5 4.5 0.74 9.9 0.6 2.3 2 0 0 2 2 2 0 Photosystem II reaction centre X protein (PsbX) Senescence PF06911.12 EXF78932.1 - 0.032 14.6 4.1 0.051 13.9 4.1 1.4 1 1 0 1 1 1 0 Senescence-associated protein VPS13_C PF16909.5 EXF78932.1 - 0.48 10.2 3.8 0.31 10.8 2.3 1.5 1 1 0 1 1 1 0 Vacuolar-sorting-associated 13 protein C-terminal tRNA-synt_2 PF00152.20 EXF78933.1 - 8.3e-87 291.2 0.0 1.4e-86 290.4 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA-synt_2b PF00587.25 EXF78933.1 - 0.12 12.4 0.1 0.16 11.9 0.1 1.5 1 1 0 1 1 1 0 tRNA synthetase class II core domain (G, H, P, S and T) ANTH PF07651.16 EXF78934.1 - 5.6e-67 225.6 0.1 7.3e-67 225.3 0.1 1.1 1 0 0 1 1 1 1 ANTH domain ENTH PF01417.20 EXF78934.1 - 1.4e-06 28.4 0.0 2.2e-06 27.7 0.0 1.3 1 0 0 1 1 1 1 ENTH domain MAT1 PF06391.13 EXF78935.1 - 1.3e-36 126.4 4.7 1.6e-36 126.1 4.7 1.1 1 0 0 1 1 1 1 CDK-activating kinase assembly factor MAT1 zf-C3HC4_5 PF17121.5 EXF78935.1 - 6.2e-30 102.9 10.1 9.8e-30 102.2 10.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EXF78935.1 - 0.00064 19.5 2.8 0.0014 18.4 2.8 1.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EXF78935.1 - 0.012 15.4 5.9 0.035 14.0 6.0 1.7 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Plug PF07715.15 EXF78935.1 - 0.035 14.7 0.0 0.061 13.9 0.0 1.4 1 0 0 1 1 1 0 TonB-dependent Receptor Plug Domain zf-RING_2 PF13639.6 EXF78935.1 - 0.1 13.0 6.4 0.18 12.2 6.4 1.4 1 0 0 1 1 1 0 Ring finger domain Zn_ribbon_17 PF17120.5 EXF78935.1 - 0.15 11.7 2.0 0.27 10.9 2.0 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type MRP-S26 PF14943.6 EXF78935.1 - 0.27 11.1 9.6 0.47 10.3 9.6 1.4 1 0 0 1 1 1 0 Mitochondrial ribosome subunit S26 zf-UDP PF14569.6 EXF78935.1 - 0.86 9.8 5.0 2.5 8.3 5.0 1.7 1 1 0 1 1 1 0 Zinc-binding RING-finger zf-RING_UBOX PF13445.6 EXF78935.1 - 0.87 9.7 5.7 1.6 8.9 5.7 1.4 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_5 PF14634.6 EXF78935.1 - 0.97 9.4 9.0 10 6.2 9.5 2.1 1 1 1 2 2 2 0 zinc-RING finger domain zf-RING_4 PF14570.6 EXF78935.1 - 1.8 8.4 10.7 32 4.4 11.6 2.2 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain CS PF04969.16 EXF78936.1 - 2.1e-18 67.1 0.1 4e-18 66.2 0.1 1.5 1 0 0 1 1 1 1 CS domain Prefoldin_3 PF13758.6 EXF78937.1 - 3.1e-33 113.8 1.5 3.1e-33 113.8 1.5 2.0 2 0 0 2 2 2 1 Prefoldin subunit DUF3835 PF12927.7 EXF78937.1 - 5.8e-19 68.7 7.9 6.3e-19 68.6 0.2 4.0 3 0 0 3 3 3 1 Domain of unknown function (DUF3835) Prefoldin_2 PF01920.20 EXF78937.1 - 0.0038 17.1 6.0 1.1 9.3 0.1 3.7 3 0 0 3 3 3 2 Prefoldin subunit FAA_hydro_N_2 PF18288.1 EXF78937.1 - 0.29 11.6 1.8 0.44 11.0 0.4 2.0 2 0 0 2 2 2 0 Fumarylacetoacetase N-terminal domain 2 ABC_tran_CTD PF16326.5 EXF78937.1 - 0.3 11.4 8.9 1.1 9.5 1.7 3.6 2 1 1 3 3 3 0 ABC transporter C-terminal domain Prefoldin PF02996.17 EXF78937.1 - 0.58 10.1 5.2 13 5.7 0.1 3.0 3 0 0 3 3 3 0 Prefoldin subunit Lzipper-MIP1 PF14389.6 EXF78937.1 - 1.2 9.5 5.5 1.1 9.6 0.6 3.1 2 1 1 3 3 3 0 Leucine-zipper of ternary complex factor MIP1 DUF4337 PF14235.6 EXF78937.1 - 1.2 9.2 3.9 26 4.9 0.2 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4337) Uds1 PF15456.6 EXF78937.1 - 5.9 7.1 9.0 8.3 6.6 1.6 2.8 2 1 0 2 2 2 0 Up-regulated During Septation DNA_repr_REX1B PF14966.6 EXF78937.1 - 7.3 7.3 7.4 6.6 7.5 0.2 3.2 2 1 1 3 3 3 0 DNA repair REX1-B p450 PF00067.22 EXF78938.1 - 4.5e-65 220.2 0.0 5.2e-65 220.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 FANC_SAP PF18081.1 EXF78938.1 - 0.13 12.4 0.3 0.31 11.3 0.3 1.6 1 0 0 1 1 1 0 Fanconi anemia-associated nuclease SAP domain SopA PF13981.6 EXF78938.1 - 0.14 12.6 0.0 0.25 11.8 0.0 1.4 1 0 0 1 1 1 0 SopA-like central domain Glyco_hydro_31 PF01055.26 EXF78939.1 - 3.2e-144 481.4 5.0 4.1e-144 481.0 5.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.5 EXF78939.1 - 7.2e-33 113.2 0.0 1.3e-32 112.4 0.0 1.4 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase zf-CCCH PF00642.24 EXF78940.1 - 1.7e-21 75.6 32.4 6.4e-08 32.3 0.7 5.4 4 1 1 5 5 5 5 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EXF78940.1 - 5e-20 70.9 30.9 1.1e-06 28.4 1.9 5.4 5 0 0 5 5 5 5 Zinc finger domain Torus PF16131.5 EXF78940.1 - 1.1e-11 45.4 24.8 0.00054 20.6 0.4 5.4 1 1 4 5 5 5 5 Torus domain zf-CCCH_4 PF18044.1 EXF78940.1 - 3.7e-08 33.0 36.7 9.6e-06 25.3 0.4 5.6 5 0 0 5 5 5 4 CCCH-type zinc finger zf-CCCH_3 PF15663.5 EXF78940.1 - 0.0039 17.4 1.4 0.0039 17.4 1.4 2.9 1 1 2 3 3 3 2 Zinc-finger containing family zf-C3H1 PF10650.9 EXF78940.1 - 0.57 10.0 4.0 2.4 8.0 0.4 3.5 3 0 0 3 3 3 0 Putative zinc-finger domain Methyltransf_23 PF13489.6 EXF78941.1 - 1.2e-12 48.0 0.0 5.4e-12 45.9 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF78941.1 - 0.00045 20.8 0.0 0.001 19.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF78941.1 - 0.00068 20.3 0.0 0.0028 18.3 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF78941.1 - 0.014 16.1 0.0 0.037 14.8 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 EXF78941.1 - 0.14 12.0 0.1 0.89 9.3 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase domain Glyco_hydro_18 PF00704.28 EXF78942.1 - 2.5e-67 227.9 0.0 2.8e-67 227.6 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Vps53_N PF04100.12 EXF78943.1 - 4.2e-105 351.8 0.2 7.2e-105 351.1 0.2 1.3 1 0 0 1 1 1 1 Vps53-like, N-terminal Vps54_N PF10475.9 EXF78943.1 - 7.1e-07 28.8 3.3 1.3e-06 27.9 3.3 1.3 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex DUF2451 PF10474.9 EXF78943.1 - 0.00045 20.1 0.0 0.00098 19.0 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function C-terminus (DUF2451) RINT1_TIP1 PF04437.13 EXF78943.1 - 0.0012 17.8 1.2 0.16 10.8 0.0 3.1 3 0 0 3 3 3 1 RINT-1 / TIP-1 family Sec6 PF06046.13 EXF78943.1 - 0.0022 16.5 0.2 0.096 11.0 0.1 2.5 2 0 0 2 2 2 1 Exocyst complex component Sec6 Zw10 PF06248.13 EXF78943.1 - 0.0071 15.0 3.2 0.015 13.9 3.2 1.5 1 0 0 1 1 1 1 Centromere/kinetochore Zw10 VPS53_C PF16854.5 EXF78943.1 - 0.012 15.5 0.0 0.051 13.5 0.0 2.0 1 1 1 2 2 2 0 Vacuolar protein sorting-associated protein 53 C-terminus DUF5082 PF16888.5 EXF78943.1 - 0.031 14.6 1.7 0.36 11.1 0.7 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) Spc7 PF08317.11 EXF78943.1 - 0.053 12.4 2.2 0.1 11.5 2.2 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein UPF0175 PF03683.13 EXF78943.1 - 0.085 12.6 0.0 0.43 10.3 0.0 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0175) DUF1664 PF07889.12 EXF78943.1 - 0.13 12.3 0.5 0.42 10.7 0.5 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Trp_repressor PF01371.19 EXF78943.1 - 0.32 11.2 2.9 13 6.0 1.3 2.8 2 0 0 2 2 2 0 Trp repressor protein DUF1776 PF08643.10 EXF78944.1 - 6.8e-106 354.0 0.0 8.6e-106 353.6 0.0 1.1 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) adh_short PF00106.25 EXF78944.1 - 0.037 13.5 0.0 0.13 11.7 0.0 1.8 2 0 0 2 2 2 0 short chain dehydrogenase MFS_1 PF07690.16 EXF78945.1 - 9.9e-19 67.5 56.0 1.4e-11 43.9 27.2 3.3 2 1 0 3 3 3 2 Major Facilitator Superfamily TRI12 PF06609.13 EXF78945.1 - 2.5e-08 32.8 19.7 3.8e-08 32.2 19.7 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Pox_A14 PF05767.12 EXF78945.1 - 0.094 12.9 0.9 0.48 10.6 0.9 2.2 1 0 0 1 1 1 0 Poxvirus virion envelope protein A14 DUF1689 PF07954.11 EXF78945.1 - 0.15 12.5 0.3 0.48 10.8 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1689) zf-CHY PF05495.12 EXF78946.1 - 2.3e-10 40.8 10.3 2.3e-10 40.8 10.3 3.4 2 1 0 2 2 2 1 CHY zinc finger RWD PF05773.22 EXF78946.1 - 0.00016 21.9 0.2 0.009 16.3 0.0 2.4 2 0 0 2 2 2 1 RWD domain Myotoxins PF00819.17 EXF78947.1 - 0.076 13.3 1.1 0.17 12.2 1.1 1.5 1 0 0 1 1 1 0 Myotoxin, crotamine DUF3243 PF11588.8 EXF78947.1 - 0.16 12.3 0.0 0.34 11.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3243) Fungal_trans PF04082.18 EXF78948.1 - 3.7e-21 75.4 0.0 5.4e-21 74.8 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF78948.1 - 4.2e-06 26.8 13.6 6.9e-06 26.1 13.6 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Gal4_dimer PF03902.13 EXF78948.1 - 0.0066 16.6 1.5 0.013 15.6 1.5 1.5 1 0 0 1 1 1 1 Gal4-like dimerisation domain Sugar_tr PF00083.24 EXF78949.1 - 4.7e-88 296.0 22.1 5.5e-88 295.8 22.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF78949.1 - 7.9e-31 107.3 32.1 5.4e-28 97.9 21.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EXF78949.1 - 6.7e-08 31.5 20.3 0.0005 18.8 2.3 3.3 3 0 0 3 3 3 3 MFS/sugar transport protein TRI12 PF06609.13 EXF78949.1 - 0.004 15.6 0.4 0.004 15.6 0.4 2.1 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) adh_short_C2 PF13561.6 EXF78950.1 - 1.9e-59 201.1 0.4 2.2e-59 200.9 0.4 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF78950.1 - 2.4e-42 144.6 0.6 3.1e-42 144.3 0.6 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EXF78950.1 - 2.7e-12 47.0 0.4 3.6e-12 46.6 0.4 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EXF78950.1 - 0.00022 20.7 0.1 0.00028 20.4 0.1 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Sacchrp_dh_NADP PF03435.18 EXF78950.1 - 0.0011 19.2 0.2 0.002 18.4 0.2 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain 2-Hacid_dh_C PF02826.19 EXF78950.1 - 0.0053 16.1 0.3 0.011 15.1 0.2 1.4 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GDP_Man_Dehyd PF16363.5 EXF78950.1 - 0.011 15.2 0.0 0.024 14.1 0.0 1.5 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase F420_oxidored PF03807.17 EXF78950.1 - 0.015 15.8 0.8 0.035 14.7 0.8 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Polysacc_synt_2 PF02719.15 EXF78950.1 - 0.029 13.5 0.0 0.037 13.2 0.0 1.1 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.19 EXF78950.1 - 0.057 12.4 0.0 0.086 11.8 0.0 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_Gly3P_dh_N PF01210.23 EXF78950.1 - 0.062 13.3 0.2 0.1 12.6 0.2 1.2 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 3HCDH_N PF02737.18 EXF78950.1 - 0.088 12.7 0.4 0.13 12.2 0.4 1.2 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain RmlD_sub_bind PF04321.17 EXF78950.1 - 0.11 11.6 0.9 0.14 11.2 0.1 1.5 2 0 0 2 2 2 0 RmlD substrate binding domain PRK PF00485.18 EXF78951.1 - 1.1e-07 31.8 0.0 1.4e-07 31.5 0.0 1.2 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family NACHT PF05729.12 EXF78951.1 - 3.1e-05 24.0 0.0 0.0012 18.8 0.0 2.5 3 0 0 3 3 3 1 NACHT domain AAA_16 PF13191.6 EXF78951.1 - 0.00027 21.3 0.0 0.00072 20.0 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain Zeta_toxin PF06414.12 EXF78951.1 - 0.00034 20.0 0.1 0.001 18.4 0.0 1.9 2 0 0 2 2 2 1 Zeta toxin NB-ARC PF00931.22 EXF78951.1 - 0.00048 19.4 0.0 0.00075 18.8 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain AAA_18 PF13238.6 EXF78951.1 - 0.0005 20.6 0.0 0.00094 19.7 0.0 1.8 1 1 0 1 1 1 1 AAA domain NTPase_1 PF03266.15 EXF78951.1 - 0.0007 19.6 0.0 0.0029 17.5 0.0 1.9 2 0 0 2 2 2 1 NTPase AAA_22 PF13401.6 EXF78951.1 - 0.00095 19.4 0.0 0.0017 18.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EXF78951.1 - 0.001 19.4 0.0 0.0024 18.2 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 EXF78951.1 - 0.0012 19.3 0.0 0.0021 18.5 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 EXF78951.1 - 0.0021 17.8 0.0 0.0038 17.0 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EXF78951.1 - 0.0024 18.1 0.0 0.0082 16.3 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 EXF78951.1 - 0.0033 17.4 0.0 0.0074 16.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) T2SSE PF00437.20 EXF78951.1 - 0.0042 16.2 0.0 0.0061 15.7 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_17 PF13207.6 EXF78951.1 - 0.0086 16.5 0.1 0.026 14.9 0.1 1.8 1 0 0 1 1 1 1 AAA domain TsaE PF02367.17 EXF78951.1 - 0.01 15.8 0.0 0.042 13.8 0.0 1.9 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_25 PF13481.6 EXF78951.1 - 0.023 14.2 0.0 0.055 13.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain SRP54 PF00448.22 EXF78951.1 - 0.028 14.0 0.0 0.038 13.6 0.0 1.2 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain RNA_helicase PF00910.22 EXF78951.1 - 0.03 14.7 0.0 0.052 13.9 0.0 1.4 1 0 0 1 1 1 0 RNA helicase AAA_24 PF13479.6 EXF78951.1 - 0.031 14.0 0.0 0.063 13.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 EXF78951.1 - 0.031 13.6 0.0 0.047 13.1 0.0 1.2 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_11 PF13086.6 EXF78951.1 - 0.07 12.9 0.0 0.098 12.4 0.0 1.2 1 0 0 1 1 1 0 AAA domain RuvB_N PF05496.12 EXF78951.1 - 0.083 12.6 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain KAP_NTPase PF07693.14 EXF78951.1 - 0.12 11.6 0.0 0.14 11.4 0.0 1.1 1 0 0 1 1 1 0 KAP family P-loop domain cobW PF02492.19 EXF78951.1 - 0.13 11.8 0.0 0.26 10.9 0.0 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain KTI12 PF08433.10 EXF78951.1 - 0.14 11.6 0.0 0.21 11.0 0.0 1.2 1 0 0 1 1 1 0 Chromatin associated protein KTI12 ATP_bind_1 PF03029.17 EXF78951.1 - 0.19 11.5 0.0 0.33 10.7 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA_7 PF12775.7 EXF78951.1 - 0.21 11.1 0.0 0.49 9.9 0.0 1.6 2 0 0 2 2 2 0 P-loop containing dynein motor region ADH_N PF08240.12 EXF78952.1 - 1.4e-31 108.5 0.4 1.4e-31 108.5 0.4 2.2 3 0 0 3 3 3 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EXF78952.1 - 8.5e-25 87.2 0.5 8.5e-25 87.2 0.5 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EXF78952.1 - 2.1e-08 33.9 0.6 1.6e-07 31.1 0.6 2.1 1 1 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 EXF78952.1 - 2.9e-06 28.4 0.1 1.1e-05 26.5 0.1 2.1 2 1 0 2 2 1 1 Zinc-binding dehydrogenase Methyltransf_25 PF13649.6 EXF78952.1 - 0.0001 22.9 0.0 0.00023 21.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EXF78952.1 - 0.0002 20.8 0.1 0.0003 20.2 0.1 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_31 PF13847.6 EXF78952.1 - 0.0047 16.7 0.1 0.0093 15.8 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain 2-Hacid_dh_C PF02826.19 EXF78952.1 - 0.0071 15.7 0.0 0.012 14.9 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Methyltransf_11 PF08241.12 EXF78952.1 - 0.0098 16.5 0.0 0.021 15.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EXF78952.1 - 0.054 12.9 0.2 0.089 12.2 0.2 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_12 PF08242.12 EXF78952.1 - 0.15 12.8 0.0 0.31 11.8 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain adh_short_C2 PF13561.6 EXF78953.1 - 5.3e-58 196.4 1.3 6.3e-58 196.1 1.3 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF78953.1 - 7e-44 149.6 1.2 8.8e-44 149.3 1.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EXF78953.1 - 6.9e-14 52.2 1.1 1.2e-13 51.4 1.1 1.3 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 EXF78953.1 - 0.014 14.8 0.9 0.036 13.5 0.9 1.7 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family NAD_binding_2 PF03446.15 EXF78953.1 - 0.041 14.0 1.0 0.073 13.2 0.2 1.8 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase Dehydratase_MU PF02288.15 EXF78953.1 - 0.092 12.6 0.3 0.17 11.8 0.3 1.4 1 0 0 1 1 1 0 Dehydratase medium subunit RmlD_sub_bind PF04321.17 EXF78953.1 - 0.12 11.4 3.7 5 6.1 1.0 2.3 1 1 1 2 2 2 0 RmlD substrate binding domain SET PF00856.28 EXF78954.1 - 1.3e-11 45.1 0.0 1.6e-10 41.6 0.0 2.1 1 1 0 1 1 1 1 SET domain Sugar_tr PF00083.24 EXF78957.1 - 5.2e-82 276.1 21.3 6.4e-82 275.8 21.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF78957.1 - 1.3e-17 63.8 50.4 9.4e-17 61.0 21.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily YebO PF13974.6 EXF78957.1 - 0.16 12.0 0.0 0.36 11.0 0.0 1.6 1 0 0 1 1 1 0 YebO-like protein DUF2456 PF10445.9 EXF78957.1 - 1.5 8.9 7.0 14 5.9 0.7 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2456) CFEM PF05730.11 EXF78958.1 - 7.8e-12 45.1 3.7 1.8e-11 44.0 3.7 1.6 1 0 0 1 1 1 1 CFEM domain PBP PF01161.20 EXF78960.1 - 9e-17 61.6 0.0 1.1e-16 61.4 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein NUDIX_4 PF14815.6 EXF78961.1 - 8.2e-21 74.1 0.1 1.9e-20 72.9 0.1 1.7 1 0 0 1 1 1 1 NUDIX domain HhH-GPD PF00730.25 EXF78961.1 - 1.7e-19 70.3 0.0 4e-19 69.1 0.0 1.6 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 EXF78961.1 - 7.2e-06 25.6 0.1 2e-05 24.2 0.1 1.8 1 0 0 1 1 1 1 Helix-hairpin-helix motif Pyr_redox_2 PF07992.14 EXF78962.1 - 1e-10 41.4 0.0 4.2e-08 32.8 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 EXF78962.1 - 2e-10 39.8 0.1 4.9e-09 35.2 0.0 2.1 2 0 0 2 2 2 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EXF78962.1 - 1.4e-08 34.4 0.0 3.9e-08 32.9 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EXF78962.1 - 1.7e-08 34.0 0.0 1.4e-06 27.7 0.0 2.5 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 EXF78962.1 - 2.6e-07 30.8 0.0 9.8e-07 28.9 0.0 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 EXF78962.1 - 0.0006 19.8 0.9 0.037 14.0 0.0 3.2 3 0 0 3 3 3 1 FAD-NAD(P)-binding Thi4 PF01946.17 EXF78962.1 - 0.0009 18.5 0.0 0.0042 16.3 0.0 2.0 2 0 0 2 2 2 1 Thi4 family Lycopene_cycl PF05834.12 EXF78962.1 - 0.001 18.2 0.0 0.0018 17.4 0.0 1.4 1 0 0 1 1 1 1 Lycopene cyclase protein 2-Hacid_dh_C PF02826.19 EXF78962.1 - 0.024 14.0 0.1 0.048 13.0 0.1 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyr_redox PF00070.27 EXF78962.1 - 0.12 13.0 0.1 16 6.1 0.0 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EXF78962.1 - 0.24 10.9 1.4 3.3 7.2 0.0 3.1 3 1 0 3 3 3 0 FAD dependent oxidoreductase Pectate_lyase PF03211.13 EXF78963.1 - 1.8e-85 285.6 9.8 2.2e-85 285.3 9.8 1.0 1 0 0 1 1 1 1 Pectate lyase Hydantoinase_B PF02538.14 EXF78964.1 - 1.4e-213 710.0 0.1 2.6e-213 709.1 0.1 1.4 2 0 0 2 2 2 1 Hydantoinase B/oxoprolinase Hydantoinase_A PF01968.18 EXF78964.1 - 1.5e-101 339.5 0.0 2.6e-100 335.4 0.0 2.3 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.13 EXF78964.1 - 4.1e-60 202.5 2.9 3.2e-58 196.4 0.0 3.3 4 0 0 4 4 4 2 Hydantoinase/oxoprolinase N-terminal region MFS_1 PF07690.16 EXF78965.1 - 8.7e-14 51.2 0.2 1e-13 51.0 0.2 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_1 PF07690.16 EXF78966.1 - 2.9e-17 62.6 8.9 4.6e-17 62.0 8.9 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily PNK3P PF08645.11 EXF78967.1 - 4.1e-58 195.6 0.0 6.1e-58 195.1 0.0 1.3 1 0 0 1 1 1 1 Polynucleotide kinase 3 phosphatase AAA_33 PF13671.6 EXF78967.1 - 1.9e-26 93.0 0.0 6.7e-24 84.7 0.0 2.4 1 1 0 1 1 1 1 AAA domain Rad17 PF03215.15 EXF78967.1 - 0.014 15.3 0.0 0.025 14.5 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_11 PF13086.6 EXF78967.1 - 0.085 12.6 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain Med18 PF09637.10 EXF78968.1 - 6.1e-29 101.6 0.0 7.6e-29 101.3 0.0 1.1 1 0 0 1 1 1 1 Med18 protein FRP PF18032.1 EXF78968.1 - 0.53 10.9 3.8 4.1 8.1 0.1 2.7 3 0 0 3 3 3 0 Photoprotection regulator fluorescence recovery protein Glyco_hydro_61 PF03443.14 EXF78969.1 - 1e-64 218.3 0.5 1.5e-64 217.7 0.5 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 Glyco_hydro_16 PF00722.21 EXF78970.1 - 2.5e-07 30.3 0.4 3.5e-05 23.3 0.1 2.2 2 0 0 2 2 2 2 Glycosyl hydrolases family 16 SKN1 PF03935.15 EXF78970.1 - 1.7e-05 23.5 0.0 0.0091 14.5 0.1 2.2 2 0 0 2 2 2 2 Beta-glucan synthesis-associated protein (SKN1) DUF3433 PF11915.8 EXF78971.1 - 4e-12 46.4 17.2 5.8e-10 39.5 3.4 3.1 3 0 0 3 3 3 2 Protein of unknown function (DUF3433) Hum_adeno_E3A PF05393.11 EXF78971.1 - 0.083 12.9 0.2 0.49 10.4 0.2 2.3 2 0 0 2 2 2 0 Human adenovirus early E3A glycoprotein DUF2085 PF09858.9 EXF78971.1 - 0.87 10.1 0.0 0.87 10.1 0.0 3.0 2 1 1 3 3 3 0 Predicted membrane protein (DUF2085) UPRTase PF14681.6 EXF78974.1 - 2.8e-18 66.1 0.0 7.1e-09 35.4 0.1 2.3 1 1 1 2 2 2 2 Uracil phosphoribosyltransferase HAD PF12710.7 EXF78974.1 - 1.2e-17 65.0 0.2 5.7e-17 62.7 0.1 2.3 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase AAA_17 PF13207.6 EXF78974.1 - 4.5e-12 46.6 0.0 8.8e-12 45.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain Hydrolase PF00702.26 EXF78974.1 - 9e-09 35.9 0.0 2.3e-08 34.6 0.0 1.7 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase AAA_16 PF13191.6 EXF78974.1 - 0.01 16.2 0.0 0.022 15.1 0.0 1.7 1 1 0 1 1 1 0 AAA ATPase domain Zeta_toxin PF06414.12 EXF78974.1 - 0.041 13.2 0.0 0.088 12.1 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin Hydrolase_3 PF08282.12 EXF78974.1 - 0.086 12.6 0.0 0.16 11.7 0.0 1.3 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase AAA_18 PF13238.6 EXF78974.1 - 0.11 13.0 0.0 0.26 11.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain Torsin PF06309.11 EXF78974.1 - 0.13 12.4 0.1 0.26 11.4 0.1 1.5 1 0 0 1 1 1 0 Torsin KAP_NTPase PF07693.14 EXF78974.1 - 0.2 10.8 0.0 0.34 10.1 0.0 1.3 1 0 0 1 1 1 0 KAP family P-loop domain MFS_1 PF07690.16 EXF78975.1 - 4.3e-46 157.5 45.5 1.5e-45 155.7 45.5 1.9 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 EXF78975.1 - 3.4e-10 39.0 22.7 4.4e-10 38.6 22.7 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Auxin_canalis PF05703.11 EXF78975.1 - 0.048 13.6 4.2 0.09 12.7 4.2 1.3 1 0 0 1 1 1 0 Auxin canalisation DUF5305 PF17231.2 EXF78975.1 - 2.4 7.5 4.1 2.4 7.5 0.0 2.9 3 0 0 3 3 3 0 Family of unknown function (DUF5305) Fungal_trans PF04082.18 EXF78976.1 - 2.4e-20 72.7 0.0 4e-20 72.0 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF78976.1 - 4.1e-09 36.4 9.2 6.7e-09 35.7 9.2 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Aconitase PF00330.20 EXF78977.1 - 5.1e-107 358.7 0.9 4.2e-106 355.7 0.9 2.0 1 1 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 EXF78977.1 - 5.2e-24 85.1 0.0 9.8e-24 84.2 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain IPPT PF01715.17 EXF78978.1 - 2.3e-62 210.8 0.1 4e-62 210.0 0.1 1.3 1 0 0 1 1 1 1 IPP transferase IPT PF01745.16 EXF78978.1 - 6.4e-05 22.4 0.0 0.00017 21.0 0.0 1.6 1 0 0 1 1 1 1 Isopentenyl transferase AAA_33 PF13671.6 EXF78978.1 - 0.0001 22.5 0.3 0.007 16.5 0.0 2.9 3 0 0 3 3 3 1 AAA domain zf-met PF12874.7 EXF78978.1 - 0.00042 20.6 1.7 0.00076 19.8 1.7 1.4 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EXF78978.1 - 0.00066 19.9 1.7 0.0012 19.1 1.7 1.4 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding AAA_28 PF13521.6 EXF78978.1 - 0.0012 19.2 0.5 0.15 12.3 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EXF78978.1 - 0.0013 19.3 0.0 0.29 11.7 0.0 2.5 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EXF78978.1 - 0.0096 16.3 0.0 0.035 14.5 0.0 2.0 2 0 0 2 2 2 1 AAA ATPase domain Hpr_kinase_C PF07475.12 EXF78978.1 - 0.017 14.7 0.0 0.03 13.9 0.0 1.3 1 0 0 1 1 1 0 HPr Serine kinase C-terminal domain Rpr2 PF04032.16 EXF78978.1 - 0.022 15.0 0.9 0.044 14.1 0.9 1.4 1 0 0 1 1 1 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain ABC_tran PF00005.27 EXF78978.1 - 0.026 15.1 0.0 0.08 13.5 0.0 1.9 2 0 0 2 2 2 0 ABC transporter zf-C2H2_2 PF12756.7 EXF78978.1 - 0.03 14.6 0.6 0.058 13.7 0.6 1.4 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) RNA_helicase PF00910.22 EXF78978.1 - 0.073 13.5 0.0 0.22 11.9 0.0 1.9 2 0 0 2 2 1 0 RNA helicase AAA_5 PF07728.14 EXF78978.1 - 0.082 12.9 0.0 0.19 11.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 EXF78978.1 - 0.094 12.4 0.0 0.19 11.5 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein PhoH PF02562.16 EXF78978.1 - 0.11 11.9 0.0 0.21 11.0 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein Hydin_ADK PF17213.3 EXF78978.1 - 0.14 12.4 1.0 0.89 9.8 0.0 2.3 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain SecY PF00344.20 EXF78979.1 - 2.7e-71 240.3 7.7 3.5e-71 240.0 7.7 1.1 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.9 EXF78979.1 - 3.2e-17 62.0 0.2 1e-16 60.5 0.2 2.0 1 0 0 1 1 1 1 Plug domain of Sec61p RELT PF12606.8 EXF78979.1 - 1.4 8.0 3.6 4.1 6.5 3.6 1.8 1 0 0 1 1 1 0 Tumour necrosis factor receptor superfamily member 19 ABC_membrane PF00664.23 EXF78980.1 - 1.8e-56 191.8 22.2 2.5e-33 115.9 7.4 3.3 3 0 0 3 3 3 3 ABC transporter transmembrane region ABC_tran PF00005.27 EXF78980.1 - 3.5e-49 166.8 4.0 2.8e-30 105.6 0.0 3.3 3 0 0 3 3 2 2 ABC transporter SMC_N PF02463.19 EXF78980.1 - 6e-05 22.6 14.1 0.0067 15.9 0.2 4.5 4 1 0 4 4 3 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EXF78980.1 - 0.00019 21.1 0.5 0.58 9.9 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain T2SSE PF00437.20 EXF78980.1 - 0.00023 20.3 0.1 0.019 14.1 0.3 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein MMR_HSR1 PF01926.23 EXF78980.1 - 0.00047 20.2 0.0 0.12 12.5 0.0 3.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_21 PF13304.6 EXF78980.1 - 0.00052 19.9 0.9 7 6.4 0.0 3.6 3 0 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 EXF78980.1 - 0.0011 19.0 0.0 0.87 9.5 0.0 2.7 2 0 0 2 2 2 2 RsgA GTPase IstB_IS21 PF01695.17 EXF78980.1 - 0.0017 18.2 0.1 0.2 11.4 0.0 2.9 3 0 0 3 3 2 1 IstB-like ATP binding protein AAA_22 PF13401.6 EXF78980.1 - 0.0019 18.5 0.1 11 6.3 0.0 3.6 3 0 0 3 3 3 0 AAA domain AAA_23 PF13476.6 EXF78980.1 - 0.0032 18.0 0.0 0.0032 18.0 0.0 4.3 4 1 0 4 4 2 2 AAA domain AAA_16 PF13191.6 EXF78980.1 - 0.0047 17.3 4.8 0.72 10.2 0.0 3.3 3 0 0 3 3 2 2 AAA ATPase domain AAA_25 PF13481.6 EXF78980.1 - 0.017 14.7 0.1 1 8.9 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 EXF78980.1 - 0.019 15.4 0.4 10 6.6 0.0 3.4 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) CbiA PF01656.23 EXF78980.1 - 0.025 14.6 0.5 0.8 9.8 0.0 3.1 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain DUF87 PF01935.17 EXF78980.1 - 0.027 14.6 0.0 0.027 14.6 0.0 3.7 3 0 0 3 3 2 0 Helicase HerA, central domain DEAD PF00270.29 EXF78980.1 - 0.074 12.8 0.1 9.6 5.9 0.0 3.3 3 0 0 3 3 3 0 DEAD/DEAH box helicase AAA_7 PF12775.7 EXF78980.1 - 0.12 11.9 0.1 18 4.8 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region Adeno_IVa2 PF02456.15 EXF78980.1 - 0.14 10.9 0.0 0.47 9.2 0.0 1.8 2 0 0 2 2 2 0 Adenovirus IVa2 protein DUF4192 PF13830.6 EXF78980.1 - 3.9 7.4 7.1 7.6 6.5 7.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4192) SAPS PF04499.15 EXF78980.1 - 8.8 5.0 15.3 18 3.9 15.3 1.5 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein TIP120 PF08623.10 EXF78981.1 - 1.1e-71 240.0 0.7 2.8e-69 232.2 0.0 3.9 3 0 0 3 3 3 1 TATA-binding protein interacting (TIP20) HEAT_2 PF13646.6 EXF78981.1 - 5.7e-11 42.7 13.5 0.19 12.2 0.9 8.3 8 1 1 9 9 9 4 HEAT repeats HEAT PF02985.22 EXF78981.1 - 1.7e-07 30.9 20.3 0.19 12.1 0.1 11.2 13 0 0 13 13 12 2 HEAT repeat Adaptin_N PF01602.20 EXF78981.1 - 9e-06 24.5 14.1 0.44 9.0 0.2 6.1 4 1 2 6 6 6 4 Adaptin N terminal region HEAT_EZ PF13513.6 EXF78981.1 - 2.9e-05 24.5 9.8 15 6.3 0.0 10.4 12 1 0 12 12 12 0 HEAT-like repeat RTP1_C1 PF10363.9 EXF78981.1 - 4.8e-05 23.5 4.5 0.37 11.0 0.0 5.6 6 1 1 7 7 7 2 Required for nuclear transport of RNA pol II C-terminus 1 Cnd1 PF12717.7 EXF78981.1 - 0.0002 21.4 13.1 0.75 9.8 0.0 6.1 5 1 0 6 6 6 2 non-SMC mitotic condensation complex subunit 1 RIX1 PF08167.12 EXF78981.1 - 0.0058 16.4 2.6 0.086 12.6 0.0 3.7 4 0 0 4 4 4 1 rRNA processing/ribosome biogenesis RICTOR_N PF14664.6 EXF78981.1 - 0.036 13.0 7.2 0.29 10.1 0.0 3.8 4 0 0 4 4 4 0 Rapamycin-insensitive companion of mTOR, N-term DUF4042 PF13251.6 EXF78981.1 - 0.046 13.4 8.3 0.22 11.2 0.3 5.3 5 1 0 5 5 5 0 Domain of unknown function (DUF4042) Cnd3 PF12719.7 EXF78981.1 - 0.11 11.7 0.5 24 4.0 0.0 4.2 5 0 0 5 5 5 0 Nuclear condensing complex subunits, C-term domain DUF3361 PF11841.8 EXF78981.1 - 0.15 12.0 10.4 3.7 7.5 0.0 5.0 5 2 1 7 7 6 0 Domain of unknown function (DUF3361) CENP-B_dimeris PF09026.10 EXF78981.1 - 4.4 7.7 12.9 10 6.5 12.9 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain PhoLip_ATPase_C PF16212.5 EXF78983.1 - 2.8e-72 243.5 21.1 2.8e-72 243.5 21.1 1.9 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EXF78983.1 - 1.9e-23 81.9 2.2 3.9e-23 80.9 0.1 2.6 3 0 0 3 3 3 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 EXF78983.1 - 1.9e-14 54.5 0.0 2.1e-08 34.7 0.0 3.3 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EXF78983.1 - 1.1e-13 51.0 0.0 2.7e-12 46.6 0.0 2.7 3 0 0 3 3 3 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 EXF78983.1 - 1e-12 48.0 0.0 3.2e-12 46.3 0.0 1.8 1 0 0 1 1 1 1 E1-E2 ATPase GGDEF_2 PF17853.1 EXF78983.1 - 0.00026 21.2 0.3 0.16 12.2 0.0 2.7 2 0 0 2 2 2 2 GGDEF-like domain Hydrolase_3 PF08282.12 EXF78983.1 - 0.0029 17.4 0.0 0.011 15.5 0.0 1.8 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Homeodomain PF00046.29 EXF78984.1 - 1.5e-19 69.6 4.3 3.4e-19 68.4 4.3 1.6 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EXF78984.1 - 0.0015 18.4 0.5 0.0047 16.8 0.5 1.9 1 0 0 1 1 1 1 Homeobox KN domain NAM-associated PF14303.6 EXF78984.1 - 0.27 12.0 5.4 0.48 11.1 5.4 1.3 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain Adaptin_binding PF10199.9 EXF78987.1 - 1.3e-14 54.8 11.5 3e-14 53.7 11.5 1.6 1 1 0 1 1 1 1 Alpha and gamma adaptin binding protein p34 CDC14 PF08045.11 EXF78987.1 - 0.42 9.7 1.5 0.61 9.1 1.5 1.2 1 0 0 1 1 1 0 Cell division control protein 14, SIN component ADH_zinc_N_2 PF13602.6 EXF78989.1 - 6.7e-20 72.5 0.2 1.9e-19 71.0 0.1 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 EXF78989.1 - 4e-14 52.7 0.7 7.4e-14 51.8 0.7 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EXF78989.1 - 0.002 17.6 0.6 0.0038 16.8 0.6 1.3 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus HlyIII PF03006.20 EXF78990.1 - 4.7e-15 55.9 8.2 6.1e-15 55.5 8.2 1.0 1 0 0 1 1 1 1 Haemolysin-III related COMP PF11598.8 EXF78991.1 - 0.12 12.9 0.2 0.21 12.1 0.2 1.3 1 0 0 1 1 1 0 Cartilage oligomeric matrix protein CENP-B_dimeris PF09026.10 EXF78991.1 - 0.19 12.1 8.6 0.41 11.1 8.6 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain ZapA PF05164.13 EXF78991.1 - 0.45 11.0 2.9 0.92 10.0 2.9 1.5 1 0 0 1 1 1 0 Cell division protein ZapA CDC45 PF02724.14 EXF78991.1 - 0.85 7.8 7.0 1.3 7.2 7.0 1.3 1 0 0 1 1 1 0 CDC45-like protein NOA36 PF06524.12 EXF78991.1 - 2 7.6 9.5 3.1 7.0 9.5 1.2 1 0 0 1 1 1 0 NOA36 protein MFS_1 PF07690.16 EXF78993.1 - 1e-18 67.4 47.8 2.4e-18 66.2 20.0 2.7 2 1 1 3 3 3 3 Major Facilitator Superfamily DUF4131 PF13567.6 EXF78993.1 - 1.3 8.7 0.0 1.3 8.7 0.0 3.0 4 0 0 4 4 4 0 Domain of unknown function (DUF4131) Fungal_trans_2 PF11951.8 EXF78995.1 - 3.5e-14 52.4 0.4 5.5e-13 48.5 0.2 1.9 1 1 0 2 2 2 2 Fungal specific transcription factor domain DUF3810 PF12725.7 EXF78996.1 - 0.068 12.5 0.1 0.087 12.2 0.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3810) AA_permease PF00324.21 EXF78997.1 - 3.6e-92 309.5 41.5 4.3e-92 309.2 41.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EXF78997.1 - 2.1e-22 79.5 43.4 2.7e-22 79.2 43.4 1.1 1 0 0 1 1 1 1 Amino acid permease Bacteriocin_IId PF09221.10 EXF78997.1 - 0.036 14.2 1.9 0.036 14.2 1.9 3.1 3 0 0 3 3 3 0 Bacteriocin class IId cyclical uberolysin-like DUF3810 PF12725.7 EXF78997.1 - 0.85 8.9 3.6 4.3 6.6 0.8 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3810) Ras PF00071.22 EXF78999.1 - 1.6e-47 161.2 0.1 1.9e-40 138.1 0.0 2.4 2 1 0 2 2 2 2 Ras family Roc PF08477.13 EXF78999.1 - 5.7e-14 52.4 0.1 2.9e-07 30.7 0.0 3.1 3 0 0 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 EXF78999.1 - 0.024 14.5 0.0 7.3 6.5 0.0 2.3 2 0 0 2 2 2 0 RsgA GTPase Abhydrolase_4 PF08386.10 EXF78999.1 - 0.057 13.5 0.0 0.11 12.6 0.0 1.4 1 0 0 1 1 1 0 TAP-like protein FeoB_N PF02421.18 EXF78999.1 - 0.098 12.2 0.0 0.82 9.2 0.0 2.2 3 0 0 3 3 3 0 Ferrous iron transport protein B AAA_16 PF13191.6 EXF78999.1 - 0.14 12.5 0.0 0.24 11.7 0.0 1.7 1 1 0 1 1 1 0 AAA ATPase domain HAD_2 PF13419.6 EXF79000.1 - 0.00018 21.7 0.0 0.00032 20.8 0.0 1.7 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EXF79000.1 - 0.0047 16.9 0.1 0.013 15.5 0.1 1.8 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 EXF79000.1 - 0.0059 16.9 0.0 0.0086 16.4 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF3381 PF11861.8 EXF79000.1 - 0.15 11.8 0.1 0.23 11.3 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) Mcp5_PH PF12814.7 EXF79001.1 - 5.9e-48 162.0 0.0 1.3e-47 160.9 0.0 1.6 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology DUF724 PF05266.14 EXF79001.1 - 0.0052 16.6 4.6 0.0097 15.8 4.6 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF724) Fez1 PF06818.15 EXF79001.1 - 0.012 16.0 16.9 0.027 14.9 16.9 1.5 1 0 0 1 1 1 0 Fez1 TPR_MLP1_2 PF07926.12 EXF79001.1 - 0.038 14.1 24.3 0.014 15.4 19.2 2.2 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein PH_12 PF16457.5 EXF79001.1 - 0.11 13.0 2.7 0.2 12.2 0.1 2.9 3 1 0 3 3 3 0 Pleckstrin homology domain CENP-F_leu_zip PF10473.9 EXF79001.1 - 0.34 10.9 14.9 0.6 10.1 14.9 1.3 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 CENP-H PF05837.12 EXF79001.1 - 1.9 8.9 10.9 7 7.1 0.8 2.6 2 0 0 2 2 2 0 Centromere protein H (CENP-H) SlyX PF04102.12 EXF79001.1 - 2.6 8.7 8.6 1.4 9.6 4.5 2.7 1 1 1 2 2 2 0 SlyX UPF0242 PF06785.11 EXF79001.1 - 3.9 7.5 10.0 7.1 6.7 10.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus ADIP PF11559.8 EXF79001.1 - 4.9 7.2 23.1 6.1 6.9 6.6 2.5 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Golgin_A5 PF09787.9 EXF79001.1 - 8.3 5.8 16.4 15 4.9 16.4 1.3 1 0 0 1 1 1 0 Golgin subfamily A member 5 OTU PF02338.19 EXF79002.1 - 3.1e-23 82.7 0.0 3.8e-22 79.1 0.0 2.4 1 1 0 1 1 1 1 OTU-like cysteine protease PAF-AH_p_II PF03403.13 EXF79002.1 - 0.0037 15.8 1.3 0.0037 15.8 1.3 1.5 2 0 0 2 2 2 1 Platelet-activating factor acetylhydrolase, isoform II Peptidase_C65 PF10275.9 EXF79002.1 - 0.005 16.3 0.0 0.15 11.5 0.0 2.5 2 0 0 2 2 2 1 Peptidase C65 Otubain Red1 PF07964.11 EXF79002.1 - 5.4 5.1 15.4 3.2 5.9 4.2 2.0 2 0 0 2 2 2 0 Rec10 / Red1 TPMT PF05724.11 EXF79003.1 - 8.5e-27 94.2 0.0 3.5e-25 89.0 0.0 2.6 1 1 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) Methyltransf_25 PF13649.6 EXF79003.1 - 1.7e-09 38.3 0.0 3.3e-05 24.5 0.0 2.3 1 1 0 2 2 2 2 Methyltransferase domain Methyltransf_31 PF13847.6 EXF79003.1 - 9e-08 32.1 0.0 5e-06 26.4 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF79003.1 - 2.5e-07 31.3 0.0 8.3e-05 23.2 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_23 PF13489.6 EXF79003.1 - 1e-06 28.7 0.0 1.6e-06 28.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF79003.1 - 4.7e-06 27.3 0.0 9e-06 26.4 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain TehB PF03848.14 EXF79003.1 - 0.0043 16.5 0.0 0.0068 15.8 0.0 1.2 1 0 0 1 1 1 1 Tellurite resistance protein TehB N2227 PF07942.12 EXF79003.1 - 0.0096 15.1 0.0 0.015 14.5 0.0 1.2 1 0 0 1 1 1 1 N2227-like protein PALP PF00291.25 EXF79004.1 - 4.4e-65 220.0 0.2 7.4e-64 216.0 0.2 2.0 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme HRDC PF00570.23 EXF79004.1 - 0.0094 15.9 0.0 1.6 8.8 0.0 2.7 2 0 0 2 2 2 2 HRDC domain DUF3343 PF11823.8 EXF79004.1 - 0.12 11.9 0.1 0.4 10.2 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3343) Transglut_core PF01841.19 EXF79004.1 - 0.13 12.8 0.0 0.25 11.8 0.0 1.4 1 0 0 1 1 1 0 Transglutaminase-like superfamily zf-C3HC4 PF00097.25 EXF79005.1 - 6.6e-08 32.3 6.1 1.1e-07 31.6 6.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EXF79005.1 - 1.5e-06 28.2 6.3 3.3e-06 27.0 6.3 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EXF79005.1 - 1.8e-06 27.7 4.1 3.5e-06 26.8 4.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EXF79005.1 - 4.2e-06 27.0 6.5 7.4e-06 26.2 6.5 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 EXF79005.1 - 1.2e-05 25.2 4.0 2.2e-05 24.3 4.0 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 EXF79005.1 - 1.2e-05 25.3 3.3 2.7e-05 24.2 3.2 1.6 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.6 EXF79005.1 - 1.8e-05 24.5 5.5 1.9e-05 24.4 1.9 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EXF79005.1 - 0.0026 17.6 7.1 0.013 15.4 7.0 2.1 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 Secretin_N_2 PF07655.13 EXF79005.1 - 0.015 15.8 1.2 0.042 14.4 1.2 1.7 1 0 0 1 1 1 0 Secretin N-terminal domain zf-rbx1 PF12678.7 EXF79005.1 - 0.093 13.0 3.5 0.23 11.7 3.5 1.7 1 0 0 1 1 1 0 RING-H2 zinc finger domain TerY_C PF15616.6 EXF79005.1 - 0.53 10.4 1.8 0.64 10.1 0.4 1.7 2 0 0 2 2 2 0 TerY-C metal binding domain zf-MIZ PF02891.20 EXF79005.1 - 0.66 9.8 5.3 2.5 7.9 5.0 2.1 1 1 1 2 2 2 0 MIZ/SP-RING zinc finger zf-RING_10 PF16685.5 EXF79005.1 - 0.94 9.7 5.2 2.4 8.4 5.2 1.7 1 1 0 1 1 1 0 zinc RING finger of MSL2 zf-RING_11 PF17123.5 EXF79005.1 - 1.8 8.4 4.8 4.9 7.0 4.8 1.8 1 0 0 1 1 1 0 RING-like zinc finger AMPK1_CBM PF16561.5 EXF79006.1 - 3.1e-16 59.3 0.5 3.1e-09 36.9 0.1 2.6 2 0 0 2 2 2 2 Glycogen recognition site of AMP-activated protein kinase PTS_IIA PF02255.16 EXF79006.1 - 0.17 12.0 6.0 1.2 9.2 6.1 2.3 2 0 0 2 2 2 0 PTS system, Lactose/Cellobiose specific IIA subunit Fungal_trans PF04082.18 EXF79009.1 - 9.7e-16 57.6 0.1 2.5e-15 56.2 0.1 1.6 1 1 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 EXF79009.1 - 7.9e-07 29.2 11.0 0.005 17.2 0.7 3.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EXF79009.1 - 0.014 16.2 10.2 0.61 11.1 2.2 3.2 3 0 0 3 3 3 0 C2H2-type zinc finger CTP_transf_like PF01467.26 EXF79011.1 - 4.4e-29 101.5 0.0 7.5e-29 100.8 0.0 1.4 1 0 0 1 1 1 1 Cytidylyltransferase-like HIGH_NTase1 PF05636.11 EXF79011.1 - 0.12 11.5 0.0 0.19 10.9 0.0 1.3 1 0 0 1 1 1 0 HIGH Nucleotidyl Transferase K_oxygenase PF13434.6 EXF79012.1 - 6.7e-16 58.4 0.0 2.2e-11 43.5 0.0 2.2 2 0 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.6 EXF79012.1 - 4.6e-11 42.5 0.0 0.00052 19.4 0.1 3.6 3 1 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EXF79012.1 - 7.2e-08 32.0 0.1 0.00049 19.4 0.1 2.6 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EXF79012.1 - 4.4e-05 23.2 2.2 0.15 11.7 4.2 3.5 2 1 1 3 3 3 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 EXF79012.1 - 0.00025 20.4 0.0 0.02 14.2 0.0 2.3 2 0 0 2 2 2 1 FAD binding domain NAD_binding_9 PF13454.6 EXF79012.1 - 0.00027 21.0 0.0 0.07 13.1 0.0 2.6 2 0 0 2 2 2 1 FAD-NAD(P)-binding HI0933_like PF03486.14 EXF79012.1 - 0.0054 15.5 0.0 0.69 8.5 0.0 2.3 2 0 0 2 2 2 2 HI0933-like protein Pyr_redox PF00070.27 EXF79012.1 - 0.028 15.0 0.0 34 5.1 0.0 3.6 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EXF79012.1 - 0.031 13.3 0.0 0.067 12.2 0.0 1.5 1 0 0 1 1 1 0 Lycopene cyclase protein Thi4 PF01946.17 EXF79012.1 - 0.034 13.4 0.0 0.06 12.6 0.0 1.4 1 0 0 1 1 1 0 Thi4 family NAD_binding_8 PF13450.6 EXF79012.1 - 0.098 12.9 0.2 0.64 10.3 0.0 2.3 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain DUF3405 PF11885.8 EXF79013.1 - 4.9e-206 685.3 0.0 6.3e-206 685.0 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3405) TcpQ PF10671.9 EXF79013.1 - 0.00096 19.2 0.3 0.0032 17.5 0.1 2.0 2 0 0 2 2 2 1 Toxin co-regulated pilus biosynthesis protein Q Ribosomal_L44 PF00935.19 EXF79014.1 - 2.7e-36 123.9 12.2 4.1e-36 123.3 12.2 1.3 1 0 0 1 1 1 1 Ribosomal protein L44 SNF2_N PF00176.23 EXF79016.1 - 1.6e-18 66.6 0.6 1.3e-17 63.5 0.6 2.1 1 1 0 1 1 1 1 SNF2 family N-terminal domain DNA_methylase PF00145.17 EXF79016.1 - 3.8e-10 39.6 0.6 2e-07 30.7 0.0 2.9 3 0 0 3 3 3 2 C-5 cytosine-specific DNA methylase zf-RING_5 PF14634.6 EXF79016.1 - 0.00073 19.4 6.5 0.00073 19.4 6.5 2.7 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4 PF00097.25 EXF79016.1 - 0.0035 17.2 2.6 0.0035 17.2 2.6 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) ResIII PF04851.15 EXF79016.1 - 0.0087 16.1 0.0 0.02 14.9 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit zf-C3HC4_2 PF13923.6 EXF79016.1 - 1.8 8.5 12.2 0.041 13.7 4.0 2.4 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EXF79016.1 - 2 8.4 9.0 1.2 9.0 6.2 2.1 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 zf-C3HC4_5 PF17121.5 EXF79016.1 - 3.9 7.4 13.5 0.026 14.4 4.6 2.1 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Ureidogly_lyase PF04115.12 EXF79017.1 - 9.5e-59 198.3 0.0 1.2e-58 198.0 0.0 1.0 1 0 0 1 1 1 1 Ureidoglycolate lyase Abhydrolase_6 PF12697.7 EXF79018.1 - 5.4e-06 27.2 10.5 1.3e-05 26.0 10.5 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family LIM PF00412.22 EXF79020.1 - 4.9e-21 74.7 16.5 2.5e-11 43.6 3.1 2.6 3 0 0 3 3 3 2 LIM domain zf-C2H2 PF00096.26 EXF79020.1 - 0.21 12.1 3.5 18 6.0 0.1 3.3 2 0 0 2 2 2 0 Zinc finger, C2H2 type DUF3405 PF11885.8 EXF79021.1 - 2.1e-194 646.9 1.2 2.1e-194 646.9 1.2 1.9 2 1 0 2 2 2 1 Protein of unknown function (DUF3405) Ank_2 PF12796.7 EXF79023.1 - 2.6e-36 124.0 0.0 6.6e-13 49.1 0.0 7.4 5 1 2 8 8 7 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EXF79023.1 - 5.9e-30 103.3 0.1 4.9e-07 30.2 0.0 7.2 5 1 3 8 8 8 6 Ankyrin repeats (many copies) Ank PF00023.30 EXF79023.1 - 1.3e-18 66.6 0.9 0.0046 17.4 0.0 9.6 10 1 0 10 10 8 3 Ankyrin repeat Ank_3 PF13606.6 EXF79023.1 - 1.4e-18 65.0 1.6 0.13 12.9 0.0 9.3 9 0 0 9 9 8 4 Ankyrin repeat Ank_5 PF13857.6 EXF79023.1 - 5.7e-16 58.4 0.0 1.1 9.7 0.0 10.9 9 3 5 14 14 13 3 Ankyrin repeats (many copies) Helo_like_N PF17111.5 EXF79023.1 - 3.2e-08 33.2 0.8 7.6e-08 32.0 0.8 1.7 1 1 0 1 1 1 1 Fungal N-terminal domain of STAND proteins SesA PF17107.5 EXF79023.1 - 1.1e-07 32.0 3.5 5.3e-07 29.8 0.6 3.3 4 0 0 4 4 3 1 N-terminal domain on NACHT_NTPase and P-loop NTPases V-SNARE PF05008.15 EXF79023.1 - 0.017 15.5 1.2 0.017 15.5 1.2 2.5 2 1 0 2 2 2 0 Vesicle transport v-SNARE protein N-terminus AIP3 PF03915.13 EXF79023.1 - 0.021 13.9 0.2 0.044 12.9 0.2 1.4 1 0 0 1 1 1 0 Actin interacting protein 3 MutS_III PF05192.18 EXF79023.1 - 0.029 14.6 8.9 3.4 7.9 9.0 2.6 1 1 0 1 1 1 0 MutS domain III 4HB_MCP_1 PF12729.7 EXF79023.1 - 0.033 13.7 0.0 0.06 12.9 0.0 1.4 1 0 0 1 1 1 0 Four helix bundle sensory module for signal transduction HrcA PF01628.21 EXF79023.1 - 0.14 12.1 1.4 0.27 11.1 1.4 1.4 1 0 0 1 1 1 0 HrcA protein C terminal domain Phage_HK97_TLTM PF06120.11 EXF79023.1 - 0.17 11.1 0.2 0.29 10.3 0.2 1.3 1 0 0 1 1 1 0 Tail length tape measure protein CHAD PF05235.14 EXF79023.1 - 0.33 10.9 3.0 0.91 9.5 2.5 1.8 1 1 0 1 1 1 0 CHAD domain Cupin_2 PF07883.11 EXF79024.1 - 8.6e-06 25.4 0.0 1.4e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 Cupin domain Cu-oxidase_2 PF07731.14 EXF79026.1 - 1.9e-47 160.4 10.1 1.2e-44 151.4 0.2 3.3 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase_3 PF07732.15 EXF79026.1 - 1.8e-42 144.1 3.1 1.8e-42 144.1 3.1 2.4 3 1 0 3 3 3 1 Multicopper oxidase Cu-oxidase PF00394.22 EXF79026.1 - 4.1e-35 121.3 0.0 1.7e-34 119.3 0.0 2.1 2 0 0 2 2 2 1 Multicopper oxidase dCMP_cyt_deam_1 PF00383.23 EXF79028.1 - 2.9e-25 88.1 1.1 4.9e-25 87.3 1.1 1.4 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EXF79028.1 - 8.4e-10 38.5 0.1 1.5e-09 37.7 0.1 1.4 1 0 0 1 1 1 1 MafB19-like deaminase zf-CCHC PF00098.23 EXF79028.1 - 9.8e-05 22.3 3.3 9.8e-05 22.3 3.3 2.2 2 0 0 2 2 2 1 Zinc knuckle CoaE PF01121.20 EXF79028.1 - 0.059 13.0 0.0 0.097 12.3 0.0 1.3 1 0 0 1 1 1 0 Dephospho-CoA kinase AAA_18 PF13238.6 EXF79028.1 - 0.13 12.8 0.0 0.28 11.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain zf-CCHC_4 PF14392.6 EXF79028.1 - 2.4 8.0 9.0 1.1 9.0 1.4 2.5 2 0 0 2 2 2 0 Zinc knuckle ATG7_N PF16420.5 EXF79029.1 - 3.6e-111 371.6 0.0 5e-111 371.1 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-like modifier-activating enzyme ATG7 N-terminus ThiF PF00899.21 EXF79029.1 - 8.4e-43 146.5 0.0 1.2e-42 146.0 0.0 1.2 1 0 0 1 1 1 1 ThiF family Shikimate_DH PF01488.20 EXF79029.1 - 0.037 14.1 0.0 0.54 10.3 0.0 2.2 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase MFS_1 PF07690.16 EXF79030.1 - 2.1e-29 102.6 34.1 2.1e-29 102.6 34.1 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF79030.1 - 2.8e-17 62.8 23.9 8.3e-15 54.6 8.4 2.4 3 0 0 3 3 3 2 Sugar (and other) transporter FAM176 PF14851.6 EXF79030.1 - 0.24 11.1 1.2 4.6 6.9 0.9 2.2 2 0 0 2 2 2 0 FAM176 family DUF1115 PF06544.12 EXF79031.1 - 6.9e-13 48.9 0.0 1e-12 48.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1115) RWD PF05773.22 EXF79031.1 - 0.046 14.0 0.3 0.079 13.3 0.3 1.4 1 0 0 1 1 1 0 RWD domain BLUF PF04940.12 EXF79031.1 - 0.12 12.6 0.0 0.24 11.6 0.0 1.5 1 0 0 1 1 1 0 Sensors of blue-light using FAD DnaJ PF00226.31 EXF79032.1 - 1.2e-11 44.6 0.0 1.9e-11 43.9 0.0 1.4 1 0 0 1 1 1 1 DnaJ domain ELFV_dehydrog PF00208.21 EXF79036.1 - 1.3e-11 44.7 0.0 2.7e-11 43.6 0.0 1.5 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ELFV_dehydrog_N PF02812.18 EXF79036.1 - 9.5e-07 28.8 0.0 1.7e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain Glyoxalase_4 PF13669.6 EXF79036.1 - 1.5e-06 28.4 0.0 4.9e-06 26.8 0.0 2.0 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase PF00903.25 EXF79036.1 - 0.00012 22.3 0.0 0.00027 21.1 0.0 1.8 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Methyltransf_25 PF13649.6 EXF79037.1 - 2.4e-10 41.0 0.0 5.3e-10 39.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF79037.1 - 7.6e-10 38.8 0.0 1.3e-09 38.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.18 EXF79037.1 - 1.8e-08 34.0 0.0 2.6e-08 33.4 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_11 PF08241.12 EXF79037.1 - 2.3e-08 34.5 0.0 5e-08 33.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Dimerisation2 PF16864.5 EXF79037.1 - 0.00023 21.1 0.0 0.00044 20.2 0.0 1.4 1 0 0 1 1 1 1 Dimerisation domain Methyltransf_12 PF08242.12 EXF79037.1 - 0.0031 18.2 0.0 0.0089 16.7 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 EXF79037.1 - 0.0038 16.6 0.0 0.01 15.2 0.0 1.7 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.17 EXF79037.1 - 0.019 14.4 0.0 0.031 13.8 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase MTS PF05175.14 EXF79037.1 - 0.024 14.2 0.0 0.051 13.1 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase small domain TetR_C_27 PF17935.1 EXF79037.1 - 0.037 14.1 0.0 0.073 13.1 0.0 1.5 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain AMP-binding PF00501.28 EXF79038.1 - 1.6e-90 303.7 0.0 2e-90 303.4 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EXF79038.1 - 5.6e-10 40.1 0.1 1.2e-09 39.0 0.1 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain GH3 PF03321.13 EXF79038.1 - 0.24 10.2 0.1 0.57 9.0 0.0 1.6 2 0 0 2 2 2 0 GH3 auxin-responsive promoter Ribosomal_S17 PF00366.20 EXF79039.1 - 1.4e-21 76.3 2.6 1.4e-21 76.3 2.6 1.6 2 0 0 2 2 2 1 Ribosomal protein S17 AAA PF00004.29 EXF79040.1 - 1.9e-38 131.9 0.0 3.5e-38 131.0 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 EXF79040.1 - 9.1e-09 35.2 0.0 1e-07 31.9 0.0 2.6 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain AAA_lid_3 PF17862.1 EXF79040.1 - 8.5e-08 31.9 0.5 2.2e-07 30.6 0.1 2.0 2 0 0 2 2 1 1 AAA+ lid domain AAA_22 PF13401.6 EXF79040.1 - 1.7e-05 25.1 0.2 0.00045 20.5 0.2 2.6 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.12 EXF79040.1 - 5.4e-05 23.0 0.0 0.0001 22.1 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EXF79040.1 - 0.00039 20.8 0.6 0.0021 18.4 0.5 2.3 1 1 0 1 1 1 1 AAA ATPase domain TIP49 PF06068.13 EXF79040.1 - 0.00095 18.5 0.0 0.0017 17.6 0.0 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain DUF815 PF05673.13 EXF79040.1 - 0.0013 17.9 0.0 0.0023 17.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_5 PF07728.14 EXF79040.1 - 0.003 17.6 0.0 0.0098 15.9 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 EXF79040.1 - 0.0032 16.9 0.1 0.01 15.2 0.1 1.8 2 0 0 2 2 1 1 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 EXF79040.1 - 0.0041 16.9 0.0 0.0078 16.0 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_14 PF13173.6 EXF79040.1 - 0.0048 16.9 0.0 0.038 14.0 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_2 PF07724.14 EXF79040.1 - 0.0067 16.6 0.0 0.014 15.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_11 PF13086.6 EXF79040.1 - 0.011 15.6 1.4 0.86 9.3 0.0 2.6 2 1 0 2 2 2 0 AAA domain AAA_33 PF13671.6 EXF79040.1 - 0.028 14.6 0.0 0.064 13.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EXF79040.1 - 0.04 14.5 0.0 0.12 12.9 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EXF79040.1 - 0.043 13.5 0.1 0.15 11.8 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.6 EXF79040.1 - 0.047 14.0 0.0 0.098 13.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 EXF79040.1 - 0.071 12.7 0.0 0.18 11.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 EXF79040.1 - 0.11 12.4 0.0 0.33 10.9 0.0 1.8 2 0 0 2 2 1 0 NACHT domain AAA_7 PF12775.7 EXF79040.1 - 0.17 11.4 0.0 0.36 10.3 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_28 PF13521.6 EXF79040.1 - 0.18 12.0 1.2 0.77 10.0 0.1 2.4 3 0 0 3 3 2 0 AAA domain PhoH PF02562.16 EXF79040.1 - 0.2 11.1 0.0 0.52 9.7 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein COG6 PF06419.11 EXF79041.1 - 4.7e-216 718.8 3.5 5.4e-216 718.6 3.5 1.0 1 0 0 1 1 1 1 Conserved oligomeric complex COG6 COG2 PF06148.11 EXF79041.1 - 0.025 14.7 0.3 0.025 14.7 0.3 2.6 3 0 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 Sec34 PF04136.15 EXF79041.1 - 0.11 12.4 2.3 1.1 9.1 0.0 3.4 3 1 1 4 4 4 0 Sec34-like family DUF948 PF06103.11 EXF79041.1 - 0.13 12.5 0.4 2 8.8 0.1 3.0 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) RmuC PF02646.16 EXF79041.1 - 0.23 10.6 3.7 0.16 11.1 0.1 2.4 2 0 0 2 2 2 0 RmuC family COG5 PF10392.9 EXF79041.1 - 1.2 9.3 6.1 0.48 10.6 0.1 3.2 4 0 0 4 4 4 0 Golgi transport complex subunit 5 ATG16 PF08614.11 EXF79041.1 - 2 8.6 9.5 8.2 6.6 1.5 2.7 2 1 0 2 2 2 0 Autophagy protein 16 (ATG16) Spc7 PF08317.11 EXF79041.1 - 4.1 6.2 7.7 0.25 10.2 0.5 2.4 2 1 1 3 3 3 0 Spc7 kinetochore protein APG9 PF04109.16 EXF79042.1 - 4.5e-194 645.9 17.2 5.2e-194 645.7 17.2 1.0 1 0 0 1 1 1 1 Autophagy protein Apg9 BTB_2 PF02214.22 EXF79043.1 - 4.8e-07 30.0 0.1 0.00094 19.5 0.0 2.4 2 0 0 2 2 2 2 BTB/POZ domain Fungal_trans PF04082.18 EXF79044.1 - 9.7e-10 37.9 0.0 2.1e-09 36.8 0.0 1.5 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF79044.1 - 3.2e-07 30.4 15.1 5.3e-07 29.7 15.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain NAD_binding_10 PF13460.6 EXF79045.1 - 7.8e-25 87.8 0.0 9.7e-25 87.5 0.0 1.1 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EXF79045.1 - 1.4e-05 24.8 0.0 2.4e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 NmrA-like family Epimerase PF01370.21 EXF79045.1 - 0.028 13.9 0.0 0.048 13.1 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family VIR_N PF15912.5 EXF79046.1 - 0.36 10.4 5.3 0.49 9.9 5.3 1.1 1 0 0 1 1 1 0 Virilizer, N-terminal DUF3632 PF12311.8 EXF79047.1 - 6.1e-13 49.6 1.8 6.6e-13 49.5 0.3 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3632) Terpene_synth_C PF03936.16 EXF79047.1 - 0.002 17.5 0.0 0.0049 16.3 0.0 1.6 2 0 0 2 2 2 1 Terpene synthase family, metal binding domain TRI5 PF06330.11 EXF79047.1 - 0.0029 16.5 0.0 0.0046 15.9 0.0 1.2 1 0 0 1 1 1 1 Trichodiene synthase (TRI5) Glyco_transf_41 PF13844.6 EXF79048.1 - 1.1e-102 344.0 0.0 8.1e-53 179.5 0.0 3.3 1 1 1 2 2 2 2 Glycosyl transferase family 41 TPR_1 PF00515.28 EXF79048.1 - 8.1e-21 72.9 1.4 0.0014 18.4 0.0 6.5 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_2 PF07719.17 EXF79048.1 - 8.4e-19 66.1 1.5 0.02 15.0 0.1 6.7 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_8 PF13181.6 EXF79048.1 - 2.8e-13 48.9 0.6 0.0061 16.7 0.0 6.2 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_11 PF13414.6 EXF79048.1 - 6.9e-12 44.9 4.7 0.0049 16.5 0.0 5.9 3 2 3 6 6 6 4 TPR repeat TPR_16 PF13432.6 EXF79048.1 - 2.7e-09 37.5 0.0 0.53 11.0 0.0 4.6 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.6 EXF79048.1 - 3.2e-09 36.5 1.1 0.0081 16.5 0.1 5.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 EXF79048.1 - 8e-09 35.6 0.9 1.5 9.8 0.0 5.9 3 2 2 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.6 EXF79048.1 - 1e-08 35.4 3.7 0.0061 16.8 0.2 4.6 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_10 PF13374.6 EXF79048.1 - 8.2e-08 31.9 5.0 0.094 12.6 0.0 5.2 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_7 PF13176.6 EXF79048.1 - 1.6e-07 30.9 0.2 0.011 15.7 0.0 4.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 EXF79048.1 - 3.1e-06 27.6 0.5 0.8 10.3 0.1 3.9 2 1 0 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 EXF79048.1 - 8.5e-05 22.6 0.6 0.45 10.7 0.1 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat BTAD PF03704.17 EXF79048.1 - 0.099 13.1 0.0 1.4 9.3 0.0 2.6 2 0 0 2 2 2 0 Bacterial transcriptional activator domain DUF237 PF03072.14 EXF79048.1 - 0.13 12.3 0.0 0.26 11.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF237) NARP1 PF12569.8 EXF79048.1 - 0.19 10.6 0.0 6.8 5.5 0.0 2.1 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 Ribosomal_L11_N PF03946.14 EXF79049.1 - 1.1e-24 86.0 0.1 1.9e-24 85.3 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.19 EXF79049.1 - 3.2e-16 59.6 0.2 5.1e-16 58.9 0.2 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain Sec23_trunk PF04811.15 EXF79050.1 - 2.9e-78 262.8 0.0 4e-78 262.3 0.0 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 EXF79050.1 - 4.5e-31 107.5 0.3 9.3e-31 106.4 0.3 1.6 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Sec23_helical PF04815.15 EXF79050.1 - 1.1e-25 89.4 0.1 4.5e-25 87.5 0.1 2.1 2 0 0 2 2 2 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.15 EXF79050.1 - 1.3e-15 57.1 5.7 2.5e-15 56.2 5.7 1.5 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 EXF79050.1 - 3.1e-12 46.2 0.0 9.3e-12 44.7 0.0 1.9 2 0 0 2 2 2 1 Gelsolin repeat Vps36-NZF-N PF16988.5 EXF79050.1 - 0.038 13.4 0.7 0.099 12.1 0.1 1.9 2 0 0 2 2 2 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain DUF1190 PF06693.11 EXF79051.1 - 0.048 14.1 0.2 0.073 13.5 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1190) MFS_1 PF07690.16 EXF79052.1 - 4.1e-45 154.3 39.9 6.4e-42 143.7 29.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF79052.1 - 4e-10 39.2 12.3 4e-10 39.2 12.3 2.6 3 1 1 4 4 4 1 Sugar (and other) transporter OATP PF03137.20 EXF79052.1 - 0.00045 18.6 3.9 0.0012 17.3 3.9 1.8 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family Lipase_GDSL_2 PF13472.6 EXF79053.1 - 7.8e-14 52.5 0.8 1e-13 52.1 0.8 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EXF79053.1 - 1.7e-05 24.9 0.0 2.1e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase DHquinase_I PF01487.15 EXF79053.1 - 0.044 14.0 0.0 0.062 13.5 0.0 1.2 1 0 0 1 1 1 0 Type I 3-dehydroquinase LRRCT PF01463.24 EXF79054.1 - 0.34 11.6 1.2 1.7 9.4 0.1 2.4 1 1 1 2 2 2 0 Leucine rich repeat C-terminal domain DUF3328 PF11807.8 EXF79055.1 - 7.5e-43 146.9 0.5 1e-42 146.4 0.5 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) PGA_cap PF09587.10 EXF79056.1 - 0.0069 15.9 1.9 0.24 10.8 0.2 2.2 1 1 1 2 2 2 2 Bacterial capsule synthesis protein PGA_cap CBP_BcsF PF11120.8 EXF79056.1 - 0.0091 16.1 3.6 52 4.1 0.0 4.7 5 1 0 5 5 5 0 Cellulose biosynthesis protein BcsF COX_ARM PF06481.14 EXF79056.1 - 0.017 15.0 0.5 34 4.5 0.0 3.3 3 0 0 3 3 3 0 COX Aromatic Rich Motif GGA_N-GAT PF18308.1 EXF79056.1 - 0.13 11.9 4.9 26 4.5 0.2 3.7 3 0 0 3 3 3 0 GGA N-GAT domain Anophelin PF10731.9 EXF79056.1 - 0.13 12.1 0.0 4.1 7.3 0.1 2.8 4 0 0 4 4 4 0 Thrombin inhibitor from mosquito Barttin PF15462.6 EXF79056.1 - 0.14 12.0 2.9 1.1 9.0 1.3 2.1 1 1 1 2 2 2 0 Bartter syndrome, infantile, with sensorineural deafness (Barttin) PAS_6 PF08348.11 EXF79056.1 - 0.2 11.5 4.8 13 5.7 0.3 3.2 1 1 4 5 5 5 0 YheO-like PAS domain DUF3048_C PF17479.2 EXF79056.1 - 0.21 12.0 3.3 13 6.2 0.3 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3048) C-terminal domain Bac_rhamnosid6H PF17389.2 EXF79057.1 - 2.9e-122 408.2 0.0 9.6e-122 406.5 0.0 1.8 2 0 0 2 2 2 1 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain Bac_rhamnosid_N PF08531.10 EXF79057.1 - 1.1e-54 184.8 0.2 2e-54 184.0 0.2 1.4 1 0 0 1 1 1 1 Alpha-L-rhamnosidase N-terminal domain Bac_rhamnosid PF05592.11 EXF79057.1 - 2.9e-28 97.8 0.0 6.1e-28 96.8 0.0 1.6 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase concanavalin-like domain Glyco_transf_28 PF03033.20 EXF79057.1 - 7e-20 71.5 0.0 1.4e-19 70.5 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain Bac_rhamnosid_C PF17390.2 EXF79057.1 - 6.4e-13 48.3 0.0 1.5e-12 47.1 0.0 1.7 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase C-terminal domain UDPGT PF00201.18 EXF79057.1 - 0.0001 21.2 0.0 0.00017 20.6 0.0 1.2 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase DUF2786 PF10979.8 EXF79057.1 - 0.075 13.0 1.4 0.16 11.9 1.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2786) Trypan_PARP PF05887.11 EXF79057.1 - 3.4 7.7 6.5 7.4 6.6 6.5 1.5 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) ketoacyl-synt PF00109.26 EXF79058.1 - 1.3e-74 250.9 0.3 2.8e-74 249.9 0.0 1.8 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.10 EXF79058.1 - 5e-58 196.0 0.1 1.5e-57 194.4 0.1 1.9 1 0 0 1 1 1 1 KR domain PS-DH PF14765.6 EXF79058.1 - 3.4e-55 187.4 0.2 5.9e-55 186.6 0.2 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 EXF79058.1 - 1.4e-46 159.5 0.2 5e-46 157.7 0.2 1.8 2 0 0 2 2 2 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EXF79058.1 - 2.2e-34 118.0 0.4 1e-33 115.9 0.0 2.4 3 0 0 3 3 2 1 Beta-ketoacyl synthase, C-terminal domain Methyltransf_12 PF08242.12 EXF79058.1 - 1.6e-20 73.7 0.0 6.2e-20 71.8 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain adh_short PF00106.25 EXF79058.1 - 8.2e-15 54.8 0.7 1.3e-11 44.3 0.1 2.6 2 0 0 2 2 2 2 short chain dehydrogenase KAsynt_C_assoc PF16197.5 EXF79058.1 - 2.4e-13 50.5 0.0 1.8e-12 47.7 0.0 2.3 1 1 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Methyltransf_25 PF13649.6 EXF79058.1 - 3.6e-13 50.0 0.1 2.2e-12 47.5 0.0 2.6 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EXF79058.1 - 5.4e-11 42.6 0.0 1.7e-10 41.0 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF79058.1 - 1.3e-10 41.7 0.0 5.8e-10 39.7 0.0 2.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF79058.1 - 2.2e-10 40.6 0.0 5.2e-10 39.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PP-binding PF00550.25 EXF79058.1 - 1e-08 35.4 0.2 2.4e-08 34.2 0.2 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site adh_short_C2 PF13561.6 EXF79058.1 - 1.7e-08 34.3 0.3 2.4e-06 27.3 0.1 2.8 3 0 0 3 3 3 1 Enoyl-(Acyl carrier protein) reductase ADH_zinc_N PF00107.26 EXF79058.1 - 4.3e-07 30.0 0.0 1.4e-06 28.3 0.0 2.0 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Ubie_methyltran PF01209.18 EXF79058.1 - 2.8e-06 26.8 0.0 5.6e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family SAT PF16073.5 EXF79058.1 - 0.00014 21.7 1.1 0.0005 19.9 1.1 1.9 1 1 0 1 1 1 1 Starter unit:ACP transacylase in aflatoxin biosynthesis Thiolase_N PF00108.23 EXF79058.1 - 0.00019 20.9 0.1 0.0013 18.2 0.0 2.3 2 0 0 2 2 2 1 Thiolase, N-terminal domain ADH_N PF08240.12 EXF79058.1 - 0.0021 17.9 0.1 0.0051 16.7 0.1 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain PCMT PF01135.19 EXF79058.1 - 0.0067 16.2 0.0 0.017 14.9 0.0 1.6 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) ADH_zinc_N_2 PF13602.6 EXF79058.1 - 0.021 15.9 0.0 0.098 13.7 0.0 2.2 2 0 0 2 2 1 0 Zinc-binding dehydrogenase Methyltransf_23 PF13489.6 EXF79059.1 - 6.2e-10 39.2 0.0 9.1e-10 38.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF79059.1 - 0.0027 18.4 0.0 0.0065 17.2 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF79059.1 - 0.01 16.5 0.0 0.02 15.6 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 EXF79059.1 - 0.015 15.1 0.0 0.11 12.3 0.0 2.1 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.12 EXF79059.1 - 0.02 15.6 0.0 0.093 13.5 0.0 2.0 1 1 0 1 1 1 0 Methyltransferase domain CT47 PF15623.6 EXF79059.1 - 0.096 12.5 2.5 0.14 11.9 2.5 1.1 1 0 0 1 1 1 0 Cancer/testis gene family 47 Methyltransf_25 PF13649.6 EXF79060.1 - 2.2e-06 28.2 0.0 3.8e-06 27.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF79060.1 - 3.1e-06 27.8 0.0 6.2e-06 26.9 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EXF79060.1 - 1.2e-05 25.2 0.0 1.6e-05 24.8 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EXF79060.1 - 0.026 14.1 0.0 0.049 13.2 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain Sugar_tr PF00083.24 EXF79061.1 - 9.8e-101 337.8 27.5 1.2e-100 337.5 27.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF79061.1 - 1.6e-32 112.8 26.5 1.6e-32 112.8 26.5 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily PT-VENN PF04829.13 EXF79061.1 - 0.011 15.8 0.7 0.038 14.1 0.7 1.9 1 0 0 1 1 1 0 Pre-toxin domain with VENN motif DUF1385 PF07136.11 EXF79061.1 - 0.74 9.1 4.5 0.58 9.4 0.9 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1385) Glyco_hydro_11 PF00457.17 EXF79062.1 - 9.3e-83 276.2 20.6 1.1e-82 276.0 20.6 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 11 Ank_2 PF12796.7 EXF79063.1 - 9.3e-14 51.8 0.1 7.8e-05 23.2 0.0 3.3 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EXF79063.1 - 3.7e-11 43.0 0.9 0.019 15.2 0.0 4.7 3 2 2 5 5 5 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 EXF79063.1 - 7e-11 42.4 0.2 6.1e-05 23.5 0.0 4.1 2 1 2 4 4 4 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EXF79063.1 - 9.8e-10 37.9 1.1 0.077 13.6 0.0 5.7 7 0 0 7 7 7 3 Ankyrin repeat Ank PF00023.30 EXF79063.1 - 1.3e-09 38.1 0.3 0.55 10.8 0.0 5.1 5 0 0 5 5 5 3 Ankyrin repeat ADH_N_2 PF16884.5 EXF79065.1 - 2.3e-30 104.6 0.0 4.4e-30 103.8 0.0 1.4 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N PF00107.26 EXF79065.1 - 1.6e-19 70.2 0.0 2.5e-19 69.6 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EXF79065.1 - 9.1e-07 30.0 0.0 1.7e-06 29.1 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase PCP_red PF08369.10 EXF79066.1 - 0.026 14.7 2.6 0.031 14.5 1.0 1.9 2 0 0 2 2 2 0 Proto-chlorophyllide reductase 57 kD subunit Oxidored_FMN PF00724.20 EXF79067.1 - 1.7e-89 300.5 0.0 1.9e-89 300.3 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family MFS_1 PF07690.16 EXF79068.1 - 9.9e-26 90.5 37.2 3.8e-16 59.0 29.7 3.4 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EXF79068.1 - 5.1e-11 41.7 11.5 1.1e-08 34.1 4.7 2.3 1 1 1 2 2 2 2 Fungal trichothecene efflux pump (TRI12) VirB8 PF04335.13 EXF79068.1 - 0.2 11.5 0.2 1.7 8.4 0.1 2.2 2 0 0 2 2 2 0 VirB8 protein Polysacc_deac_1 PF01522.21 EXF79069.1 - 1.5e-11 44.2 0.0 2.6e-11 43.5 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase Fungal_trans PF04082.18 EXF79070.1 - 5.4e-29 101.0 0.4 9.4e-29 100.3 0.4 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Transp_cyt_pur PF02133.15 EXF79071.1 - 4.5e-87 292.7 43.4 5.3e-87 292.4 43.4 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Amidase PF01425.21 EXF79072.1 - 6.2e-70 236.4 0.0 1.7e-69 235.0 0.0 1.6 1 1 0 1 1 1 1 Amidase Aminotran_1_2 PF00155.21 EXF79073.1 - 2.9e-16 59.6 0.0 3.5e-16 59.3 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.7 EXF79073.1 - 0.00039 19.3 0.0 0.014 14.2 0.0 2.6 1 1 0 1 1 1 1 Alanine-glyoxylate amino-transferase TPP_enzyme_N PF02776.18 EXF79075.1 - 2.7e-31 108.5 0.5 4.7e-31 107.7 0.5 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 EXF79075.1 - 1.3e-17 64.0 0.0 2.6e-16 59.8 0.0 2.5 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 EXF79075.1 - 4.2e-16 58.9 0.0 9e-16 57.8 0.0 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain ADH_zinc_N PF00107.26 EXF79076.1 - 1.9e-12 47.3 0.0 3.3e-12 46.5 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase adh_short PF00106.25 EXF79076.1 - 0.0015 18.0 0.2 0.0024 17.4 0.2 1.3 1 0 0 1 1 1 1 short chain dehydrogenase ADH_N PF08240.12 EXF79076.1 - 0.0088 15.9 0.0 0.018 14.9 0.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain AlaDh_PNT_C PF01262.21 EXF79076.1 - 0.15 11.3 0.3 0.27 10.5 0.3 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain HET PF06985.11 EXF79077.1 - 2.1e-32 112.5 0.0 3.3e-32 111.9 0.0 1.3 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Zip PF02535.22 EXF79078.1 - 2.4e-31 109.2 37.1 1.6e-13 50.6 2.5 3.6 3 1 1 4 4 4 3 ZIP Zinc transporter TMEM213 PF15192.6 EXF79078.1 - 2.4 8.2 4.5 0.86 9.6 0.9 2.1 2 0 0 2 2 2 0 TMEM213 family MFS_1 PF07690.16 EXF79080.1 - 5.9e-29 101.1 33.1 3.4e-28 98.6 23.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF79080.1 - 0.00052 19.0 17.4 0.0026 16.7 17.2 2.1 1 1 0 1 1 1 1 Sugar (and other) transporter DIOX_N PF14226.6 EXF79081.1 - 1.8e-14 54.5 0.0 3.7e-14 53.5 0.0 1.6 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EXF79081.1 - 9.5e-14 51.7 0.0 1.7e-13 50.9 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily HET PF06985.11 EXF79082.1 - 1e-11 45.4 0.0 1.9e-11 44.5 0.0 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) BNR PF02012.20 EXF79083.1 - 0.057 13.4 2.9 5.8 7.3 0.3 3.2 2 0 0 2 2 2 0 BNR/Asp-box repeat Tryp_inh PF17983.1 EXF79083.1 - 7.7 6.7 6.7 6 7.0 0.6 2.3 2 0 0 2 2 2 0 Trypsin inhibitors 1,2 and 3 FAD_binding_4 PF01565.23 EXF79084.1 - 3.1e-18 65.9 1.8 8.1e-18 64.5 1.8 1.8 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EXF79084.1 - 6.7e-08 32.5 0.3 1.3e-07 31.6 0.3 1.4 1 0 0 1 1 1 1 Berberine and berberine like GST_N_3 PF13417.6 EXF79086.1 - 6.9e-11 42.4 0.2 5e-10 39.6 0.1 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 EXF79086.1 - 4.2e-10 39.8 0.0 6.3e-10 39.3 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EXF79086.1 - 5e-09 36.3 0.0 9.8e-09 35.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EXF79086.1 - 5.3e-05 23.3 0.0 9.8e-05 22.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EXF79086.1 - 8.3e-05 22.7 0.0 0.00016 21.8 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EXF79086.1 - 0.00073 19.5 0.0 0.0022 18.0 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain FAA_hydrolase PF01557.18 EXF79087.1 - 1.7e-57 194.6 0.0 2.4e-57 194.1 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family FAA_hydrolase_N PF09298.11 EXF79087.1 - 2.4e-32 111.3 0.0 4.2e-32 110.5 0.0 1.4 1 0 0 1 1 1 1 Fumarylacetoacetase N-terminal Zn_clus PF00172.18 EXF79088.1 - 0.00043 20.3 3.7 0.00064 19.8 3.7 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RIC3 PF15361.6 EXF79088.1 - 0.078 13.4 0.4 0.27 11.6 0.0 1.9 2 0 0 2 2 2 0 Resistance to inhibitors of cholinesterase homologue 3 Fungal_trans PF04082.18 EXF79089.1 - 9.5e-20 70.7 0.1 2.1e-19 69.6 0.1 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain MFS_1 PF07690.16 EXF79090.1 - 9.2e-34 116.9 12.9 9.2e-34 116.9 12.9 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily AAA_33 PF13671.6 EXF79091.1 - 0.0024 18.0 0.0 0.0054 16.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain APS_kinase PF01583.20 EXF79091.1 - 0.0029 17.5 0.0 0.0048 16.8 0.0 1.3 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_16 PF13191.6 EXF79091.1 - 0.011 16.2 0.0 0.023 15.1 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain AAA_18 PF13238.6 EXF79091.1 - 0.02 15.4 0.0 0.051 14.1 0.0 1.8 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 EXF79091.1 - 0.037 13.3 0.0 0.064 12.5 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin MeaB PF03308.16 EXF79091.1 - 0.07 12.1 0.0 0.11 11.5 0.0 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB NB-ARC PF00931.22 EXF79091.1 - 0.14 11.3 0.1 0.42 9.8 0.0 1.7 2 0 0 2 2 2 0 NB-ARC domain Torsin PF06309.11 EXF79091.1 - 0.2 11.7 0.0 0.45 10.6 0.0 1.5 1 0 0 1 1 1 0 Torsin Iso_dh PF00180.20 EXF79092.1 - 7.8e-88 294.9 0.0 8.8e-88 294.8 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase DUF4875 PF16175.5 EXF79092.1 - 0.072 13.2 0.1 0.26 11.4 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4875) SAM_2 PF07647.17 EXF79092.1 - 0.092 12.9 0.0 0.27 11.4 0.0 1.8 2 0 0 2 2 2 0 SAM domain (Sterile alpha motif) PTS_EIIC_2 PF13303.6 EXF79092.1 - 0.13 11.3 0.1 0.17 10.9 0.1 1.1 1 0 0 1 1 1 0 Phosphotransferase system, EIIC MFS_Mycoplasma PF07672.13 EXF79093.1 - 0.0077 15.5 0.3 0.0077 15.5 0.3 2.1 2 0 0 2 2 2 1 Mycoplasma MFS transporter MFS_1 PF07690.16 EXF79094.1 - 2.1e-32 112.4 39.2 2.8e-32 112.0 38.5 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily DUF1516 PF07457.11 EXF79094.1 - 8.6 6.6 8.9 0.92 9.7 0.5 3.2 2 1 0 3 3 3 0 Protein of unknown function (DUF1516) Shisa PF13908.6 EXF79095.1 - 0.0031 17.8 0.5 0.0031 17.8 0.5 2.2 1 1 1 2 2 2 1 Wnt and FGF inhibitory regulator QueF_N PF14819.6 EXF79098.1 - 0.0071 16.6 0.0 0.01 16.1 0.0 1.2 1 0 0 1 1 1 1 Nitrile reductase, 7-cyano-7-deazaguanine-reductase N-term PhyH PF05721.13 EXF79099.1 - 3.5e-05 24.1 0.1 0.00014 22.2 0.1 1.9 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) p450 PF00067.22 EXF79100.1 - 9.4e-29 100.4 0.0 1.2e-28 100.1 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 FMO-like PF00743.19 EXF79101.1 - 8.5e-12 44.3 0.0 1.8e-11 43.2 0.0 1.4 1 1 0 1 1 1 1 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.6 EXF79101.1 - 4.5e-07 30.0 0.1 2.3e-06 27.7 0.0 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 EXF79101.1 - 2.8e-05 23.5 0.0 0.00022 20.6 0.0 2.2 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EXF79101.1 - 0.0012 18.0 0.0 0.13 11.3 0.0 2.5 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 EXF79101.1 - 0.099 12.6 0.0 0.18 11.8 0.0 1.5 1 0 0 1 1 1 0 FAD-NAD(P)-binding LIN52 PF10044.9 EXF79101.1 - 0.16 12.7 0.0 0.3 11.8 0.0 1.4 1 0 0 1 1 1 0 Retinal tissue protein p450 PF00067.22 EXF79102.1 - 9.4e-48 163.1 0.0 1.6e-47 162.3 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 Transferase PF02458.15 EXF79104.1 - 2e-05 23.4 0.0 0.00036 19.3 0.0 2.2 1 1 0 1 1 1 1 Transferase family PSK_trans_fac PF07704.11 EXF79104.1 - 0.18 12.6 0.3 0.18 12.6 0.3 2.4 3 0 0 3 3 3 0 Rv0623-like transcription factor Ilar_coat PF01787.16 EXF79105.1 - 0.16 11.7 0.0 0.28 11.0 0.0 1.3 1 0 0 1 1 1 0 Ilarvirus coat protein Corona_S2 PF01601.16 EXF79106.1 - 0.36 9.3 0.5 0.53 8.7 0.5 1.1 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein DUF4692 PF15763.5 EXF79107.1 - 0.36 11.3 2.9 0.43 11.0 2.9 1.1 1 0 0 1 1 1 0 Regulator of human erythroid cell expansion (RHEX) Bac_rhamnosid6H PF17389.2 EXF79108.1 - 1.3e-15 57.6 0.4 1.1e-13 51.2 0.7 2.7 2 1 0 2 2 2 2 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain Fungal_trans PF04082.18 EXF79110.1 - 6.4e-07 28.7 0.2 1.1e-06 27.8 0.2 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Peptidase_S10 PF00450.22 EXF79112.1 - 5.4e-89 299.5 0.0 6.4e-89 299.3 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase Glyco_hydro_127 PF07944.12 EXF79113.1 - 3e-16 59.0 0.0 7.4e-15 54.4 0.0 2.1 2 0 0 2 2 2 2 Beta-L-arabinofuranosidase, GH127 MFS_1 PF07690.16 EXF79114.1 - 9.3e-38 130.0 34.1 9.3e-38 130.0 34.1 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EXF79114.1 - 1e-05 24.2 12.8 1e-05 24.2 12.8 2.0 1 1 1 2 2 2 1 Fungal trichothecene efflux pump (TRI12) 7TM_GPCR_Srz PF10325.9 EXF79114.1 - 1.9 7.7 6.4 4.1 6.7 0.2 2.2 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srz Fungal_trans PF04082.18 EXF79115.1 - 4.3e-21 75.1 0.0 6.5e-21 74.6 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF79115.1 - 4.6e-08 33.1 13.8 8.5e-08 32.2 13.8 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Glyoxalase PF00903.25 EXF79116.1 - 2.2e-13 50.5 0.0 3.6e-13 49.8 0.0 1.3 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Abhydrolase_8 PF06259.12 EXF79116.1 - 0.15 11.7 0.0 0.23 11.0 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase adh_short PF00106.25 EXF79118.1 - 5.2e-24 84.8 0.0 1.1e-21 77.2 0.0 2.2 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF79118.1 - 1.8e-14 53.8 0.0 1.7e-07 31.1 0.0 2.2 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF79118.1 - 0.0026 17.7 0.1 0.051 13.5 0.0 2.1 2 0 0 2 2 2 1 KR domain MlaD PF02470.20 EXF79118.1 - 0.043 14.1 0.0 0.086 13.1 0.0 1.5 1 0 0 1 1 1 0 MlaD protein NAD_binding_10 PF13460.6 EXF79118.1 - 0.057 13.3 0.1 0.12 12.3 0.1 1.5 1 0 0 1 1 1 0 NAD(P)H-binding Amidase PF01425.21 EXF79119.1 - 2.1e-32 112.7 0.6 4.2e-32 111.7 0.6 1.4 1 0 0 1 1 1 1 Amidase Amino_oxidase PF01593.24 EXF79120.1 - 4.5e-35 121.8 0.2 5.5e-35 121.5 0.2 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EXF79120.1 - 9.1e-07 29.0 0.0 2.2e-06 27.8 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EXF79120.1 - 0.0009 18.9 0.0 0.0018 17.9 0.0 1.6 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 EXF79120.1 - 0.016 14.5 0.2 0.028 13.7 0.2 1.4 1 0 0 1 1 1 0 FAD binding domain Pyr_redox_2 PF07992.14 EXF79120.1 - 0.025 13.8 0.1 0.05 12.8 0.1 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EXF79120.1 - 0.03 13.6 0.0 0.055 12.7 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase MFS_1 PF07690.16 EXF79121.1 - 6.3e-29 101.0 47.7 3.5e-15 55.8 11.0 2.6 2 1 1 3 3 3 2 Major Facilitator Superfamily TRI12 PF06609.13 EXF79121.1 - 7.2e-14 51.1 23.4 7.2e-13 47.8 23.4 1.9 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EXF79121.1 - 6.8e-07 28.5 7.5 6.8e-07 28.5 7.5 3.6 3 2 1 4 4 4 2 Sugar (and other) transporter PALP PF00291.25 EXF79122.1 - 9e-28 97.5 0.0 5e-23 82.0 0.0 2.2 2 0 0 2 2 2 2 Pyridoxal-phosphate dependent enzyme Rhodanese PF00581.20 EXF79122.1 - 1.7e-05 25.3 0.0 8.4e-05 23.1 0.0 2.0 2 0 0 2 2 2 1 Rhodanese-like domain MFS_1 PF07690.16 EXF79123.1 - 1.3e-24 86.8 37.9 4.9e-23 81.6 35.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TraL PF07178.11 EXF79123.1 - 0.7 10.4 5.0 0.65 10.5 0.4 3.2 3 0 0 3 3 3 0 TraL protein Sterol-sensing PF12349.8 EXF79123.1 - 3.2 7.6 8.2 9.5 6.0 0.5 2.6 2 0 0 2 2 2 0 Sterol-sensing domain of SREBP cleavage-activation FAD_binding_3 PF01494.19 EXF79124.1 - 1.1e-64 218.9 0.0 1.6e-64 218.4 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EXF79124.1 - 0.0037 16.5 0.0 0.27 10.4 0.0 3.3 2 1 2 4 4 4 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EXF79124.1 - 0.0038 17.8 0.0 0.0097 16.4 0.0 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DUF1314 PF07013.11 EXF79124.1 - 0.16 11.8 0.0 0.31 10.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1314) p450 PF00067.22 EXF79125.1 - 6e-61 206.6 0.0 1.5e-60 205.3 0.0 1.6 1 1 0 1 1 1 1 Cytochrome P450 Nitroreductase PF00881.24 EXF79126.1 - 7.1e-16 58.7 0.0 9.3e-16 58.3 0.0 1.1 1 0 0 1 1 1 1 Nitroreductase family MauE PF07291.11 EXF79126.1 - 0.074 12.8 0.0 6.6 6.5 0.0 2.2 2 0 0 2 2 2 0 Methylamine utilisation protein MauE MFS_1 PF07690.16 EXF79127.1 - 7.6e-42 143.5 45.3 8.4e-42 143.4 42.8 2.2 2 1 0 2 2 2 1 Major Facilitator Superfamily Ribonuc_L-PSP PF01042.21 EXF79127.1 - 6.9e-12 45.5 0.0 1.3e-11 44.6 0.0 1.4 1 0 0 1 1 1 1 Endoribonuclease L-PSP Sugar_tr PF00083.24 EXF79128.1 - 5.5e-88 295.8 19.7 6.3e-88 295.6 19.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF79128.1 - 2.8e-19 69.3 30.1 4.8e-13 48.7 12.1 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MLTD_N PF06474.12 EXF79128.1 - 0.069 13.3 0.5 0.21 11.8 0.5 1.8 1 0 0 1 1 1 0 MltD lipid attachment motif ADH_N PF08240.12 EXF79129.1 - 7e-19 67.7 0.2 1.3e-18 66.9 0.2 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EXF79129.1 - 1.1e-11 44.8 1.3 2.3e-11 43.8 0.2 1.9 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EXF79129.1 - 0.005 17.9 0.0 0.021 15.9 0.0 2.0 2 0 0 2 2 2 1 Zinc-binding dehydrogenase PUA PF01472.20 EXF79129.1 - 0.11 12.5 0.0 0.24 11.4 0.0 1.5 1 0 0 1 1 1 0 PUA domain Fungal_trans PF04082.18 EXF79131.1 - 2.1e-28 99.1 0.0 5.5e-28 97.7 0.0 1.7 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF79131.1 - 3.8e-09 36.5 7.6 6.2e-09 35.8 7.6 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF4306 PF14154.6 EXF79131.1 - 0.13 12.4 0.1 0.25 11.5 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4306) Fungal_trans PF04082.18 EXF79132.1 - 3.8e-26 91.7 0.2 5.9e-26 91.1 0.2 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF79132.1 - 1.1e-07 31.9 7.7 1.9e-07 31.1 7.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EXF79134.1 - 1.5e-25 89.8 0.0 3.1e-25 88.7 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF79134.1 - 2.1e-09 37.3 10.9 3.3e-09 36.7 10.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ExbD PF02472.16 EXF79136.1 - 0.018 15.2 3.8 0.024 14.8 1.3 2.1 2 0 0 2 2 2 0 Biopolymer transport protein ExbD/TolR Ribosomal_S17_N PF16205.5 EXF79137.1 - 4.4e-33 113.5 0.6 7.1e-33 112.8 0.6 1.4 1 0 0 1 1 1 1 Ribosomal_S17 N-terminal Ribosomal_S17 PF00366.20 EXF79137.1 - 1.1e-26 92.8 0.2 2.1e-26 91.8 0.2 1.5 1 0 0 1 1 1 1 Ribosomal protein S17 Spc7_N PF15402.6 EXF79138.1 - 1.1e-192 642.8 117.2 1.2e-99 334.9 71.3 4.7 2 1 1 3 3 3 2 N-terminus of kinetochore NMS complex subunit Spc7 Spc7 PF08317.11 EXF79138.1 - 5.3e-127 423.0 9.0 1.5e-126 421.5 9.0 1.8 1 0 0 1 1 1 1 Spc7 kinetochore protein Spc7_C2 PF15577.6 EXF79138.1 - 2.1e-22 78.9 0.3 4.1e-22 78.0 0.3 1.5 1 0 0 1 1 1 1 Spc7_C2 COG2 PF06148.11 EXF79138.1 - 0.15 12.2 2.8 0.45 10.6 2.8 1.8 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 Herpes_UL25 PF01499.16 EXF79138.1 - 0.15 10.5 1.9 0.41 9.1 1.9 1.7 1 0 0 1 1 1 0 Herpesvirus UL25 family Csm1_N PF18504.1 EXF79138.1 - 0.29 11.5 12.5 1.4 9.3 8.0 3.6 3 0 0 3 3 3 0 Csm1 N-terminal domain Laminin_II PF06009.12 EXF79138.1 - 0.61 10.1 8.7 3.3 7.7 6.4 2.9 2 1 1 3 3 3 0 Laminin Domain II BLOC1_2 PF10046.9 EXF79138.1 - 0.85 10.0 6.8 1.4 9.3 4.7 2.3 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 kleA_kleC PF17383.2 EXF79138.1 - 1.2 9.5 6.4 5.4 7.4 6.3 2.3 1 1 0 1 1 1 0 Uncharacterized KorC regulated protein A V_ATPase_I PF01496.19 EXF79138.1 - 1.9 6.3 3.3 5 4.9 3.3 1.6 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Cnn_1N PF07989.11 EXF79138.1 - 3.2 8.0 10.8 1.5 9.0 6.4 2.9 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 LPP PF04728.13 EXF79138.1 - 4.2 7.8 6.1 5.6 7.4 1.9 3.2 3 0 0 3 3 3 0 Lipoprotein leucine-zipper DUF4404 PF14357.6 EXF79138.1 - 8.1 7.2 8.8 9.2 7.0 5.4 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) Phytoreo_S7 PF07236.11 EXF79139.1 - 0.11 10.8 0.6 0.19 10.1 0.6 1.3 1 0 0 1 1 1 0 Phytoreovirus S7 protein Atg14 PF10186.9 EXF79140.1 - 1.2e-76 257.9 0.0 1.6e-76 257.5 0.0 1.0 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 Prefoldin_2 PF01920.20 EXF79140.1 - 0.11 12.4 0.9 0.2 11.6 0.9 1.4 1 0 0 1 1 1 0 Prefoldin subunit DUF3807 PF12720.7 EXF79142.1 - 3.2e-35 122.1 2.7 7.9e-35 120.8 2.7 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF3807) Pkinase PF00069.25 EXF79143.1 - 1.3e-56 191.8 0.1 1.7e-56 191.5 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF79143.1 - 1.8e-12 47.1 0.0 2.9e-12 46.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EXF79143.1 - 0.03 14.2 0.0 6.2 6.7 0.1 2.5 1 1 1 2 2 2 0 Phosphotransferase enzyme family Aconitase_B_N PF11791.8 EXF79143.1 - 0.12 12.4 0.0 0.37 10.9 0.0 1.7 2 0 0 2 2 2 0 Aconitate B N-terminal domain Scm3 PF10384.9 EXF79144.1 - 3.3e-19 68.4 0.0 1.3e-18 66.5 0.0 2.2 1 0 0 1 1 1 1 Centromere protein Scm3 APG6 PF04111.12 EXF79145.1 - 6.7e-70 234.7 0.0 1.1e-69 234.0 0.0 1.3 1 0 0 1 1 1 1 Apg6 BARA domain APG6_N PF17675.1 EXF79145.1 - 3e-38 131.3 15.3 4.9e-38 130.7 15.3 1.3 1 0 0 1 1 1 1 Apg6 coiled-coil region Pertus-S4-tox PF09275.10 EXF79145.1 - 0.093 13.0 0.0 0.2 11.9 0.0 1.5 1 0 0 1 1 1 0 Pertussis toxin S4 subunit UPF0242 PF06785.11 EXF79145.1 - 1.5 8.9 12.2 3 7.9 12.2 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus zf-C4H2 PF10146.9 EXF79145.1 - 8.9 6.6 15.2 0.7 10.2 10.3 1.7 2 1 0 2 2 2 0 Zinc finger-containing protein AAA PF00004.29 EXF79146.1 - 2.8e-12 47.2 0.0 6.6e-12 46.0 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EXF79146.1 - 0.00025 21.5 0.1 0.00061 20.2 0.1 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EXF79146.1 - 0.042 14.1 0.1 0.17 12.2 0.1 1.9 1 1 1 2 2 2 0 AAA domain AAA_5 PF07728.14 EXF79146.1 - 0.048 13.6 0.0 0.13 12.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) CPT PF07931.12 EXF79146.1 - 0.081 12.8 0.0 0.33 10.8 0.0 1.9 1 1 1 2 2 2 0 Chloramphenicol phosphotransferase-like protein Trypan_PARP PF05887.11 EXF79148.1 - 0.99 9.4 8.0 1.6 8.7 8.0 1.4 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) ANAPC4_WD40 PF12894.7 EXF79149.1 - 5.1e-18 65.2 0.0 5.7e-05 23.3 0.0 5.7 4 2 2 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EXF79149.1 - 6.1e-18 64.8 15.8 0.0011 19.7 0.1 7.1 7 0 0 7 7 7 4 WD domain, G-beta repeat eIF2A PF08662.11 EXF79149.1 - 2e-05 24.5 0.3 0.022 14.7 0.0 3.1 3 0 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 EXF79149.1 - 0.082 11.9 0.1 23 3.8 0.0 3.5 2 1 2 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 EXF79149.1 - 0.1 11.9 0.0 0.24 10.7 0.0 1.6 1 0 0 1 1 1 0 WD40-like domain FYDLN_acid PF09538.10 EXF79149.1 - 0.62 10.8 1.7 2.5 8.8 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (FYDLN_acid) HIRA_B PF09453.10 EXF79149.1 - 1.6 8.6 5.7 0.27 11.1 1.1 2.2 2 0 0 2 2 2 0 HIRA B motif Abhydrolase_6 PF12697.7 EXF79150.1 - 2e-18 67.8 0.6 4.4e-18 66.7 0.6 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EXF79150.1 - 1.5e-17 64.1 0.0 2.4e-17 63.4 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EXF79150.1 - 5.4e-13 48.8 0.0 3.6e-12 46.1 0.0 2.1 1 1 0 1 1 1 1 Serine aminopeptidase, S33 DSPc PF00782.20 EXF79150.1 - 7.3e-11 42.0 0.0 1.2e-10 41.3 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Thioesterase PF00975.20 EXF79150.1 - 1.3e-07 32.0 0.0 2.7e-07 30.9 0.0 1.5 1 0 0 1 1 1 1 Thioesterase domain PGAP1 PF07819.13 EXF79150.1 - 0.00011 22.1 0.0 0.00082 19.2 0.0 2.0 2 0 0 2 2 2 1 PGAP1-like protein PTPlike_phytase PF14566.6 EXF79150.1 - 0.0013 18.9 0.0 0.0022 18.1 0.0 1.3 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase PF00102.27 EXF79150.1 - 0.0015 18.2 0.0 0.0025 17.4 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DUF3089 PF11288.8 EXF79150.1 - 0.0056 16.2 0.0 0.0098 15.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3089) VirJ PF06057.11 EXF79150.1 - 0.0063 16.4 0.0 0.012 15.6 0.0 1.3 1 0 0 1 1 1 1 Bacterial virulence protein (VirJ) LIDHydrolase PF10230.9 EXF79150.1 - 0.0081 15.7 0.0 0.014 14.9 0.0 1.3 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Abhydrolase_3 PF07859.13 EXF79150.1 - 0.0098 15.8 0.0 0.019 14.8 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Lipase_3 PF01764.25 EXF79150.1 - 0.032 14.1 0.0 0.14 12.1 0.0 2.0 1 1 0 1 1 1 0 Lipase (class 3) DUF900 PF05990.12 EXF79150.1 - 0.032 13.7 0.0 0.051 13.1 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) Thiolase_C PF02803.18 EXF79150.1 - 0.035 13.8 0.1 3 7.5 0.0 2.8 3 0 0 3 3 3 0 Thiolase, C-terminal domain Esterase PF00756.20 EXF79150.1 - 0.11 12.2 0.0 1.2 8.7 0.0 2.2 2 0 0 2 2 2 0 Putative esterase Herpes_US12 PF05363.12 EXF79150.1 - 0.24 12.2 1.0 0.56 11.0 1.0 1.5 1 0 0 1 1 1 0 Herpesvirus US12 family DUF498 PF04430.14 EXF79151.1 - 4.3e-30 104.0 0.0 5.8e-30 103.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF498/DUF598) Ribosomal_L34e PF01199.18 EXF79152.1 - 4.8e-42 142.2 1.7 4.8e-42 142.2 1.7 2.0 2 1 0 2 2 2 1 Ribosomal protein L34e Vps36-NZF-N PF16988.5 EXF79152.1 - 0.096 12.1 0.0 0.29 10.6 0.0 1.9 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain FhuF_C PF11575.8 EXF79152.1 - 3.3 7.7 5.4 4 7.5 0.3 2.6 3 0 0 3 3 3 0 FhuF 2Fe-2S C-terminal domain FAR1 PF03101.15 EXF79153.1 - 1.9e-05 25.3 0.2 3.9e-05 24.3 0.2 1.4 1 0 0 1 1 1 1 FAR1 DNA-binding domain Tektin PF03148.14 EXF79153.1 - 0.0033 16.2 0.0 0.0047 15.7 0.0 1.1 1 0 0 1 1 1 1 Tektin family AFT PF08731.11 EXF79153.1 - 0.048 14.1 0.1 0.077 13.4 0.1 1.3 1 0 0 1 1 1 0 Transcription factor AFT Matrilin_ccoil PF10393.9 EXF79153.1 - 0.093 12.6 0.4 0.2 11.6 0.1 1.7 2 0 0 2 2 2 0 Trimeric coiled-coil oligomerisation domain of matrilin CLZ PF16526.5 EXF79153.1 - 0.095 13.1 0.3 0.53 10.7 0.2 1.8 1 1 1 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels XhlA PF10779.9 EXF79153.1 - 0.12 12.6 0.0 0.33 11.2 0.0 1.7 1 1 0 1 1 1 0 Haemolysin XhlA Hemagglutinin PF00509.18 EXF79153.1 - 0.12 10.8 0.0 0.17 10.3 0.0 1.1 1 0 0 1 1 1 0 Haemagglutinin HSBP1 PF06825.12 EXF79153.1 - 1.6 8.7 3.1 12 5.9 0.2 2.5 2 1 0 2 2 2 0 Heat shock factor binding protein 1 Alk_phosphatase PF00245.20 EXF79154.1 - 9.7e-103 344.3 0.0 1.2e-102 344.0 0.0 1.1 1 0 0 1 1 1 1 Alkaline phosphatase Metalloenzyme PF01676.18 EXF79154.1 - 0.00019 20.9 0.0 0.00039 19.9 0.0 1.5 1 0 0 1 1 1 1 Metalloenzyme superfamily S_100 PF01023.19 EXF79154.1 - 0.063 13.0 0.1 0.15 11.8 0.1 1.6 1 0 0 1 1 1 0 S-100/ICaBP type calcium binding domain DNA_pol3_delta PF06144.13 EXF79154.1 - 0.14 12.0 0.1 0.32 10.8 0.1 1.5 1 0 0 1 1 1 0 DNA polymerase III, delta subunit LRR_4 PF12799.7 EXF79155.1 - 0.041 14.3 9.2 39 4.9 2.4 6.4 5 2 0 5 5 5 0 Leucine Rich repeats (2 copies) Rad9 PF04139.13 EXF79156.1 - 2.8e-48 164.6 0.0 3.4e-48 164.3 0.0 1.1 1 0 0 1 1 1 1 Rad9 Hus1 PF04005.12 EXF79156.1 - 0.023 13.8 0.0 0.035 13.2 0.0 1.2 1 0 0 1 1 1 0 Hus1-like protein RCC1 PF00415.18 EXF79157.1 - 4.8e-34 116.7 5.8 1.1e-10 42.0 0.0 7.2 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EXF79157.1 - 1.4e-18 66.2 23.3 2.4e-05 24.0 0.7 6.1 7 1 0 7 7 7 4 Regulator of chromosome condensation (RCC1) repeat PDH PF02153.17 EXF79158.1 - 1e-13 50.9 0.0 1.6e-13 50.3 0.0 1.2 1 0 0 1 1 1 1 Prephenate dehydrogenase F420_oxidored PF03807.17 EXF79158.1 - 1.2e-07 32.3 0.0 2.3e-07 31.3 0.0 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 EXF79158.1 - 1.3e-07 32.0 0.1 2.7e-07 30.9 0.1 1.6 1 1 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh_C PF02826.19 EXF79158.1 - 7.4e-05 22.2 0.0 0.00014 21.3 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ApbA PF02558.16 EXF79158.1 - 0.0046 16.6 0.0 0.0092 15.6 0.0 1.5 1 1 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Shikimate_DH PF01488.20 EXF79158.1 - 0.0095 16.0 0.0 0.021 14.9 0.0 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase TrkA_N PF02254.18 EXF79158.1 - 0.01 16.1 0.0 0.028 14.7 0.0 1.7 1 0 0 1 1 1 0 TrkA-N domain EccE PF11203.8 EXF79158.1 - 0.041 14.2 1.2 11 6.4 0.3 3.2 3 0 0 3 3 3 0 Putative type VII ESX secretion system translocon, EccE 3HCDH_N PF02737.18 EXF79158.1 - 0.051 13.4 0.2 0.12 12.3 0.0 1.7 1 1 1 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain XdhC_C PF13478.6 EXF79158.1 - 0.1 13.1 0.1 0.46 11.0 0.0 2.0 2 0 0 2 2 2 0 XdhC Rossmann domain Mpv17_PMP22 PF04117.12 EXF79160.1 - 2.1e-10 40.6 2.5 2.1e-10 40.6 2.5 2.2 3 0 0 3 3 3 1 Mpv17 / PMP22 family EAP30 PF04157.16 EXF79161.1 - 1.8e-76 256.5 0.2 2e-76 256.4 0.2 1.0 1 0 0 1 1 1 1 EAP30/Vps36 family Ribosomal_S9 PF00380.19 EXF79162.1 - 9.6e-33 113.3 0.3 1.1e-32 113.1 0.3 1.0 1 0 0 1 1 1 1 Ribosomal protein S9/S16 CFEM PF05730.11 EXF79163.1 - 1.8e-12 47.1 9.2 3.3e-12 46.3 9.2 1.4 1 0 0 1 1 1 1 CFEM domain Frag1 PF10277.9 EXF79167.1 - 3.4e-36 124.8 10.9 3.4e-36 124.8 10.9 2.8 3 0 0 3 3 3 1 Frag1/DRAM/Sfk1 family Exo_endo_phos PF03372.23 EXF79167.1 - 0.03 13.8 0.0 0.074 12.5 0.0 1.6 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family PsiA PF06952.11 EXF79167.1 - 0.41 9.8 1.3 0.57 9.4 0.4 1.6 2 0 0 2 2 2 0 PsiA protein U3_assoc_6 PF08640.11 EXF79168.1 - 4.5e-28 97.1 4.6 1.8e-27 95.2 1.0 2.6 2 1 1 3 3 3 1 U3 small nucleolar RNA-associated protein 6 NRDE-2 PF08424.10 EXF79168.1 - 6.3e-05 22.2 0.4 0.00015 21.0 0.2 1.6 2 0 0 2 2 2 1 NRDE-2, necessary for RNA interference TPR_14 PF13428.6 EXF79168.1 - 0.0049 17.6 0.0 14 6.8 0.0 3.7 3 1 1 4 4 4 2 Tetratricopeptide repeat RPN2_C PF18004.1 EXF79168.1 - 1.1 9.2 4.6 1.8 8.5 4.6 1.3 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain EVE PF01878.18 EXF79169.1 - 2.2e-42 144.5 0.1 2.2e-42 144.5 0.1 1.7 2 0 0 2 2 2 1 EVE domain Presenilin PF01080.17 EXF79169.1 - 3.3 6.4 6.0 4.4 6.0 6.0 1.2 1 0 0 1 1 1 0 Presenilin SRP-alpha_N PF04086.13 EXF79169.1 - 4.5 7.1 15.7 7.8 6.3 15.7 1.4 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Ndc1_Nup PF09531.10 EXF79169.1 - 5.7 5.5 8.8 6.8 5.2 8.8 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup PALP PF00291.25 EXF79170.1 - 3.5e-61 207.2 6.8 4e-61 207.0 6.8 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme PLDc_N PF13396.6 EXF79172.1 - 0.11 12.4 2.6 0.74 9.8 2.6 2.5 1 0 0 1 1 1 0 Phospholipase_D-nuclease N-terminal PBP PF01161.20 EXF79173.1 - 1.9e-17 63.8 0.1 2.9e-17 63.2 0.1 1.2 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein RdRP_4 PF02123.16 EXF79173.1 - 0.069 12.0 0.5 0.11 11.4 0.5 1.3 1 0 0 1 1 1 0 Viral RNA-directed RNA-polymerase DUF1179 PF06678.11 EXF79173.1 - 0.56 10.2 3.9 13 5.8 0.7 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1179) p450 PF00067.22 EXF79174.1 - 1.6e-70 238.1 0.0 1.9e-70 237.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Amidase PF01425.21 EXF79175.1 - 1.6e-62 211.9 0.5 6.2e-36 124.3 0.3 3.1 3 0 0 3 3 3 3 Amidase Methyltransf_23 PF13489.6 EXF79176.1 - 8.7e-23 81.0 0.0 1.2e-22 80.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF79176.1 - 8e-08 32.9 0.0 1.9e-07 31.7 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF79176.1 - 5e-06 27.2 0.0 2.1e-05 25.1 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF79176.1 - 1.3e-05 25.7 0.0 2.6e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF79176.1 - 0.00069 19.4 0.0 0.035 13.9 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 EXF79176.1 - 0.037 13.4 0.0 0.37 10.1 0.0 2.3 2 1 0 2 2 2 0 ubiE/COQ5 methyltransferase family Methyltransf_16 PF10294.9 EXF79176.1 - 0.056 13.2 0.0 0.084 12.6 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase Sugar_tr PF00083.24 EXF79177.1 - 1e-76 258.6 26.4 1.2e-76 258.4 26.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF79177.1 - 8.1e-16 57.9 30.7 8.1e-16 57.9 30.7 1.8 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF79179.1 - 2.1e-89 300.5 17.8 2.6e-89 300.2 17.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF79179.1 - 5.8e-36 124.1 43.1 1.2e-27 96.8 26.9 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EXF79179.1 - 1.5e-05 23.6 7.6 5.2e-05 21.9 3.0 2.2 2 0 0 2 2 2 2 Fungal trichothecene efflux pump (TRI12) Folate_carrier PF01770.18 EXF79179.1 - 0.00031 19.6 0.2 0.068 11.9 0.1 2.3 2 0 0 2 2 2 2 Reduced folate carrier DUF3792 PF12670.7 EXF79179.1 - 0.017 15.2 0.3 0.017 15.2 0.3 4.5 5 0 0 5 5 5 0 Protein of unknown function (DUF3792) Phage_holin_3_2 PF04550.12 EXF79179.1 - 0.082 13.5 0.1 0.24 12.0 0.1 1.7 1 0 0 1 1 1 0 Phage holin family 2 CTP_synth_N PF06418.14 EXF79180.1 - 1.1e-121 405.1 0.1 1.5e-121 404.8 0.1 1.1 1 0 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.28 EXF79180.1 - 2.3e-51 174.3 0.0 3.5e-51 173.7 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I TPP_enzyme_M_2 PF16582.5 EXF79180.1 - 0.0071 16.1 0.0 0.012 15.3 0.0 1.3 1 0 0 1 1 1 1 Middle domain of thiamine pyrophosphate Peptidase_C26 PF07722.13 EXF79180.1 - 0.011 15.6 0.1 0.069 12.9 0.1 2.2 1 1 0 1 1 1 0 Peptidase C26 CbiA PF01656.23 EXF79180.1 - 0.083 13.0 0.0 0.15 12.1 0.0 1.5 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain ARID PF01388.21 EXF79181.1 - 1.6e-13 51.1 0.3 6e-13 49.3 0.0 2.1 2 0 0 2 2 2 1 ARID/BRIGHT DNA binding domain CDC73_N PF16050.5 EXF79181.1 - 0.77 9.0 6.1 0.034 13.5 0.4 1.6 2 0 0 2 2 2 0 Paf1 complex subunit CDC73 N-terminal Img2 PF05046.14 EXF79182.1 - 8.6e-22 77.2 0.0 1.3e-21 76.7 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial large subunit ribosomal protein (Img2) Poly_export PF02563.16 EXF79182.1 - 0.027 14.7 0.0 3.1 8.1 0.0 2.2 2 0 0 2 2 2 0 Polysaccharide biosynthesis/export protein SUI1 PF01253.22 EXF79182.1 - 0.041 14.4 0.0 0.059 13.9 0.0 1.2 1 0 0 1 1 1 0 Translation initiation factor SUI1 eIF3_N PF09440.10 EXF79183.1 - 1.8e-44 151.4 0.5 6.6e-44 149.6 0.2 2.1 2 0 0 2 2 2 1 eIF3 subunit 6 N terminal domain PCI PF01399.27 EXF79183.1 - 1.7e-13 51.0 0.0 5.1e-13 49.4 0.0 1.9 1 0 0 1 1 1 1 PCI domain RPN7 PF10602.9 EXF79183.1 - 0.021 14.5 0.1 0.062 13.0 0.1 1.7 2 0 0 2 2 2 0 26S proteasome subunit RPN7 TPR_14 PF13428.6 EXF79183.1 - 0.11 13.4 0.7 7.9 7.6 0.0 3.1 2 0 0 2 2 2 0 Tetratricopeptide repeat ANAPC1 PF12859.7 EXF79184.1 - 1.7e-41 141.8 0.3 4.9e-41 140.3 0.3 1.9 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 1 PC_rep PF01851.22 EXF79184.1 - 0.65 10.5 8.2 2.4 8.7 0.2 4.4 5 0 0 5 5 5 0 Proteasome/cyclosome repeat Clathrin PF00637.20 EXF79185.1 - 2.5e-19 69.6 6.2 2.5e-19 69.6 3.5 2.4 2 1 0 2 2 2 1 Region in Clathrin and VPS BUD22 PF09073.10 EXF79185.1 - 0.00059 19.3 16.3 0.00059 19.3 16.3 2.2 2 0 0 2 2 2 1 BUD22 Vps39_1 PF10366.9 EXF79185.1 - 0.0035 17.6 0.6 0.012 15.9 0.6 1.9 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 1 NBP1 PF08537.10 EXF79185.1 - 0.0097 15.4 1.9 0.017 14.5 1.9 1.3 1 0 0 1 1 1 1 Fungal Nap binding protein NBP1 WD40_like PF17005.5 EXF79185.1 - 0.012 14.9 0.0 0.026 13.9 0.0 1.5 2 0 0 2 2 2 0 WD40-like domain zf-RING_5 PF14634.6 EXF79185.1 - 0.015 15.2 3.8 0.037 14.0 3.8 1.7 1 1 0 1 1 1 0 zinc-RING finger domain WD40 PF00400.32 EXF79185.1 - 0.074 14.0 0.8 13 6.9 0.1 3.8 3 0 0 3 3 3 0 WD domain, G-beta repeat Tom6 PF17112.5 EXF79185.1 - 0.083 12.4 0.0 0.22 11.0 0.0 1.7 1 0 0 1 1 1 0 Mitochondrial import receptor subunit Tom6, fungal Mpp10 PF04006.12 EXF79185.1 - 0.14 10.5 21.8 0.29 9.6 21.8 1.4 1 0 0 1 1 1 0 Mpp10 protein DUF913 PF06025.12 EXF79185.1 - 0.18 10.8 3.2 0.35 9.8 3.2 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) zf-RING_2 PF13639.6 EXF79185.1 - 0.26 11.6 2.9 0.28 11.6 0.6 2.1 2 0 0 2 2 2 0 Ring finger domain zf-RING_UBOX PF13445.6 EXF79185.1 - 0.32 11.0 3.1 0.14 12.2 0.2 1.9 2 0 0 2 2 2 0 RING-type zinc-finger YL1 PF05764.13 EXF79185.1 - 0.46 10.6 18.6 0.013 15.7 11.9 1.9 2 0 0 2 2 2 0 YL1 nuclear protein zf-RING_11 PF17123.5 EXF79185.1 - 0.66 9.8 4.3 1.4 8.8 4.3 1.6 1 0 0 1 1 1 0 RING-like zinc finger SpoIIIAH PF12685.7 EXF79185.1 - 0.81 9.5 8.8 0.47 10.3 6.1 1.9 2 0 0 2 2 2 0 SpoIIIAH-like protein SAPS PF04499.15 EXF79185.1 - 1.1 8.0 10.0 3.7 6.2 9.5 1.9 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein DNA_pol_phi PF04931.13 EXF79185.1 - 1.7 6.6 39.0 3.1 5.8 39.0 1.3 1 0 0 1 1 1 0 DNA polymerase phi Nop14 PF04147.12 EXF79185.1 - 5 5.2 34.2 9 4.4 34.2 1.3 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.12 EXF79185.1 - 7.7 5.8 32.7 1.3 8.3 28.0 1.9 2 0 0 2 2 2 0 SDA1 Shisa PF13908.6 EXF79186.1 - 0.23 11.7 6.3 0.29 11.4 6.3 1.2 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator DUF1180 PF06679.12 EXF79186.1 - 0.64 10.4 6.1 0.76 10.2 5.8 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1180) GatB_N PF02934.15 EXF79188.1 - 2.7e-100 335.3 0.0 6.4e-100 334.0 0.0 1.6 2 0 0 2 2 2 1 GatB/GatE catalytic domain GatB_Yqey PF02637.18 EXF79188.1 - 6.2e-08 32.6 0.5 1.9e-07 31.1 0.0 2.0 2 0 0 2 2 2 1 GatB domain DnaJ PF00226.31 EXF79189.1 - 4.6e-08 33.1 3.4 6.1e-08 32.7 0.7 2.5 3 0 0 3 3 3 1 DnaJ domain Spc110_C PF18520.1 EXF79189.1 - 0.083 12.5 0.0 0.16 11.6 0.0 1.4 1 0 0 1 1 1 0 Spindle pole body component 110 C-terminal domain Pex14_N PF04695.13 EXF79189.1 - 0.15 12.8 0.2 0.15 12.8 0.2 2.8 2 1 2 4 4 4 0 Peroxisomal membrane anchor protein (Pex14p) conserved region ETRAMP PF09716.10 EXF79189.1 - 0.15 12.2 0.0 0.65 10.1 0.0 1.9 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) DEAD PF00270.29 EXF79190.1 - 5.6e-43 146.7 0.0 8.2e-43 146.2 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EXF79190.1 - 7.2e-28 97.1 0.6 7.1e-27 93.9 0.3 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EXF79190.1 - 0.00097 19.2 0.0 0.0016 18.5 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 EXF79190.1 - 0.092 12.1 0.0 0.19 11.1 0.0 1.4 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit AAA_16 PF13191.6 EXF79191.1 - 1.5e-09 38.5 7.9 0.0013 19.1 0.0 5.3 6 0 0 6 6 6 3 AAA ATPase domain NACHT PF05729.12 EXF79191.1 - 2.1e-08 34.3 3.8 4.2e-05 23.5 0.2 4.4 4 1 0 4 4 4 2 NACHT domain AAA_22 PF13401.6 EXF79191.1 - 1.2e-05 25.6 0.0 0.0067 16.7 0.0 4.3 4 0 0 4 4 4 1 AAA domain SesA PF17107.5 EXF79191.1 - 0.0077 16.4 1.8 0.0077 16.4 1.8 3.4 4 0 0 4 4 3 1 N-terminal domain on NACHT_NTPase and P-loop NTPases ABC_tran PF00005.27 EXF79191.1 - 0.013 16.0 0.0 0.11 13.1 0.0 2.5 2 0 0 2 2 2 0 ABC transporter NB-ARC PF00931.22 EXF79191.1 - 0.016 14.4 0.0 0.088 12.0 0.0 2.2 2 0 0 2 2 2 0 NB-ARC domain Metal_resist PF13801.6 EXF79191.1 - 0.052 13.7 0.2 0.17 12.1 0.2 1.9 1 0 0 1 1 1 0 Heavy-metal resistance AAA_18 PF13238.6 EXF79191.1 - 0.06 13.9 0.0 0.88 10.1 0.0 2.7 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 EXF79191.1 - 0.089 13.2 0.0 0.34 11.3 0.0 2.1 1 0 0 1 1 1 0 RNA helicase AAA_PrkA PF08298.11 EXF79191.1 - 0.14 11.1 0.0 1.3 7.8 0.0 2.1 2 0 0 2 2 2 0 PrkA AAA domain APS_kinase PF01583.20 EXF79191.1 - 0.15 11.9 0.0 0.32 10.9 0.0 1.5 1 0 0 1 1 1 0 Adenylylsulphate kinase PXA PF02194.15 EXF79191.1 - 0.21 11.6 0.7 9.3 6.2 0.0 2.7 2 0 0 2 2 2 0 PXA domain DUF948 PF06103.11 EXF79191.1 - 0.23 11.7 0.9 1.1 9.5 0.4 2.4 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) BLOC1_2 PF10046.9 EXF79191.1 - 3.4 8.0 7.5 21 5.5 0.2 3.7 4 0 0 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Syntaxin PF00804.25 EXF79191.1 - 4.1 7.0 10.7 0.51 10.0 3.5 2.8 3 0 0 3 3 3 0 Syntaxin LrgB PF04172.16 EXF79193.1 - 5e-55 186.3 9.0 5e-55 186.3 9.0 2.4 2 0 0 2 2 2 1 LrgB-like family LrgA PF03788.14 EXF79193.1 - 0.0085 16.0 10.2 0.0085 16.0 10.2 3.7 4 1 1 5 5 5 1 LrgA family DUF1614 PF07758.11 EXF79193.1 - 3.1 7.8 23.6 0.3 11.1 1.2 3.9 3 1 1 4 4 4 0 Protein of unknown function (DUF1614) COesterase PF00135.28 EXF79194.1 - 1.9e-39 135.9 0.0 5.5e-39 134.4 0.0 1.6 1 1 0 1 1 1 1 Carboxylesterase family zf-C2H2 PF00096.26 EXF79195.1 - 0.00027 21.2 12.8 0.007 16.8 2.1 2.5 2 0 0 2 2 2 2 Zinc finger, C2H2 type Integrin_B_tail PF07965.12 EXF79195.1 - 0.028 14.9 0.8 0.057 13.9 0.1 1.7 1 1 1 2 2 2 0 Integrin beta tail domain zf-C2H2_4 PF13894.6 EXF79195.1 - 0.033 15.0 10.4 0.23 12.4 1.5 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EXF79195.1 - 0.035 14.6 2.3 0.035 14.6 2.3 2.8 3 0 0 3 3 3 0 Zinc-finger double domain zf-met PF12874.7 EXF79195.1 - 0.21 12.0 7.7 0.46 10.9 0.4 2.5 2 0 0 2 2 2 0 Zinc-finger of C2H2 type Zn_clus PF00172.18 EXF79196.1 - 4.7e-06 26.6 8.5 9e-06 25.7 8.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF4570 PF15134.6 EXF79196.1 - 0.093 12.7 0.2 0.2 11.7 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4570) Aldo_ket_red PF00248.21 EXF79197.1 - 5.2e-71 239.2 0.0 6.3e-71 239.0 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Shal-type PF11601.8 EXF79197.1 - 0.14 11.8 0.6 0.29 10.7 0.6 1.5 1 0 0 1 1 1 0 Shal-type voltage-gated potassium channels, N-terminal Epimerase PF01370.21 EXF79198.1 - 1.9e-22 79.9 0.0 2.3e-22 79.6 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EXF79198.1 - 1.6e-15 56.9 0.0 2.2e-15 56.4 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 EXF79198.1 - 4e-11 42.9 0.0 6.3e-11 42.3 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 EXF79198.1 - 4.2e-07 29.4 0.0 6.3e-07 28.8 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.12 EXF79198.1 - 8.5e-07 28.4 0.0 0.032 13.4 0.0 2.6 2 1 0 2 2 2 2 Male sterility protein adh_short PF00106.25 EXF79198.1 - 0.0002 20.9 0.0 0.0057 16.1 0.0 2.6 2 1 0 2 2 2 1 short chain dehydrogenase NAD_binding_10 PF13460.6 EXF79198.1 - 0.00063 19.7 0.0 0.00092 19.1 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Ldh_1_N PF00056.23 EXF79198.1 - 0.0089 16.1 0.1 0.017 15.2 0.1 1.5 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain NmrA PF05368.13 EXF79198.1 - 0.029 13.9 0.2 1.1 8.8 0.0 2.2 2 0 0 2 2 2 0 NmrA-like family Polysacc_synt_2 PF02719.15 EXF79198.1 - 0.081 12.0 0.0 0.24 10.5 0.0 1.7 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein FMN_dh PF01070.18 EXF79199.1 - 5.4e-116 387.4 0.0 7e-116 387.0 0.0 1.1 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.28 EXF79199.1 - 1.1e-18 67.1 0.0 2.7e-18 65.9 0.0 1.7 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Glu_synthase PF01645.17 EXF79199.1 - 0.00033 19.9 0.0 0.0007 18.8 0.0 1.4 1 0 0 1 1 1 1 Conserved region in glutamate synthase ThiG PF05690.14 EXF79199.1 - 0.0021 17.4 0.1 0.099 11.9 0.0 2.3 1 1 1 2 2 2 1 Thiazole biosynthesis protein ThiG IMPDH PF00478.25 EXF79199.1 - 0.0029 16.6 0.2 0.0084 15.1 0.2 1.7 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain NMO PF03060.15 EXF79199.1 - 0.035 13.5 0.0 0.058 12.8 0.0 1.3 1 0 0 1 1 1 0 Nitronate monooxygenase DHDPS PF00701.22 EXF79200.1 - 1.9e-41 141.7 0.0 2.3e-41 141.4 0.0 1.1 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family GGDEF_2 PF17853.1 EXF79200.1 - 0.046 14.0 0.0 0.091 13.0 0.0 1.5 1 0 0 1 1 1 0 GGDEF-like domain DUF2196 PF09962.9 EXF79200.1 - 0.15 12.0 0.0 0.28 11.2 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2196) BNR_2 PF13088.6 EXF79201.1 - 6.9e-67 225.7 0.9 8.2e-67 225.4 0.9 1.0 1 0 0 1 1 1 1 BNR repeat-like domain BNR PF02012.20 EXF79201.1 - 4.9e-05 22.7 12.2 0.54 10.5 1.3 4.7 5 0 0 5 5 5 3 BNR/Asp-box repeat PSII_BNR PF14870.6 EXF79201.1 - 0.0009 18.6 0.5 0.066 12.5 0.0 2.9 3 0 0 3 3 3 1 Photosynthesis system II assembly factor YCF48 Sortilin-Vps10 PF15902.5 EXF79201.1 - 0.0065 15.3 0.6 0.27 10.0 0.1 2.6 2 1 0 2 2 2 1 Sortilin, neurotensin receptor 3, BNR_3 PF13859.6 EXF79201.1 - 0.0088 15.4 0.0 0.046 13.0 0.0 2.0 2 1 0 2 2 2 1 BNR repeat-like domain Glyco_hydro_43 PF04616.14 EXF79201.1 - 0.024 14.0 0.0 0.051 12.9 0.0 1.6 1 0 0 1 1 1 0 Glycosyl hydrolases family 43 BNR_4 PF15892.5 EXF79201.1 - 0.048 13.0 0.1 6.9 5.9 0.0 2.5 2 1 0 2 2 2 0 BNR repeat-containing family member DUF4185 PF13810.6 EXF79201.1 - 0.1 11.8 4.8 0.71 9.1 0.4 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF4185) Sugar_tr PF00083.24 EXF79202.1 - 7.5e-91 305.2 17.2 8.8e-91 305.0 17.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF79202.1 - 3.5e-22 78.8 17.5 3.5e-22 78.8 17.5 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily MFS_5 PF05631.14 EXF79202.1 - 0.00026 20.0 0.6 0.0027 16.7 0.0 2.5 3 0 0 3 3 3 1 Sugar-tranasporters, 12 TM FtsK_4TM PF13491.6 EXF79202.1 - 0.15 11.7 0.1 0.15 11.7 0.1 3.4 3 0 0 3 3 3 0 4TM region of DNA translocase FtsK/SpoIIIE DUF1330 PF07045.11 EXF79203.1 - 0.11 12.9 0.0 0.15 12.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1330) Aminotran_3 PF00202.21 EXF79204.1 - 2e-87 293.5 0.0 2.8e-87 293.0 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III Fungal_trans_2 PF11951.8 EXF79204.1 - 1.4e-32 113.0 0.2 2.2e-32 112.3 0.2 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Pec_lyase_C PF00544.19 EXF79206.1 - 6.1e-42 143.6 4.8 9.3e-42 143.0 4.8 1.2 1 0 0 1 1 1 1 Pectate lyase Beta_helix PF13229.6 EXF79206.1 - 6.2e-07 29.4 14.7 2.9e-05 24.0 3.4 2.4 1 1 1 2 2 2 2 Right handed beta helix region PSI_PsaH PF03244.14 EXF79206.1 - 0.02 14.4 0.1 0.046 13.2 0.1 1.6 1 0 0 1 1 1 0 Photosystem I reaction centre subunit VI MIP PF00230.20 EXF79207.1 - 6e-48 163.5 13.0 7.7e-48 163.2 13.0 1.1 1 0 0 1 1 1 1 Major intrinsic protein HPP PF04982.13 EXF79208.1 - 2.6e-41 140.6 6.0 2.6e-41 140.6 6.0 1.7 2 0 0 2 2 2 1 HPP family Ion_trans_2 PF07885.16 EXF79208.1 - 0.11 12.5 1.9 0.44 10.5 0.1 2.5 2 0 0 2 2 2 0 Ion channel Virul_fac_BrkB PF03631.15 EXF79208.1 - 1.5 8.4 8.7 2 7.9 0.4 2.1 2 0 0 2 2 2 0 Virulence factor BrkB adh_short PF00106.25 EXF79209.1 - 1.4e-26 93.2 0.6 1.3e-22 80.3 0.5 2.3 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EXF79209.1 - 1.5e-14 54.1 0.1 9.2e-13 48.3 0.2 2.1 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF79209.1 - 8.3e-06 25.8 0.1 1.8e-05 24.7 0.1 1.5 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 EXF79209.1 - 0.0037 16.8 0.1 0.012 15.1 0.1 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EXF79209.1 - 0.021 14.2 0.1 0.041 13.3 0.1 1.5 1 1 0 1 1 1 0 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 EXF79209.1 - 0.03 13.5 0.1 0.078 12.1 0.0 1.7 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein Methyltransf_PK PF05891.12 EXF79209.1 - 0.044 13.3 0.0 0.074 12.6 0.0 1.3 1 0 0 1 1 1 0 AdoMet dependent proline di-methyltransferase DUF3176 PF11374.8 EXF79210.1 - 0.025 14.8 1.9 0.056 13.7 1.9 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3176) NrfD PF03916.14 EXF79210.1 - 0.052 13.2 4.7 0.091 12.4 4.7 1.3 1 0 0 1 1 1 0 Polysulphide reductase, NrfD p450 PF00067.22 EXF79211.1 - 4.5e-46 157.6 0.0 8.3e-46 156.7 0.0 1.3 1 1 0 1 1 1 1 Cytochrome P450 Peptidase_M28 PF04389.17 EXF79212.1 - 7.9e-21 74.7 0.0 1.5e-20 73.8 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 EXF79212.1 - 1.3e-11 44.3 0.3 1.2e-10 41.3 0.1 2.4 1 1 1 2 2 2 1 PA domain Peptidase_M20 PF01546.28 EXF79212.1 - 0.0086 15.8 0.0 0.016 14.9 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 TFR_dimer PF04253.15 EXF79212.1 - 0.077 13.1 0.0 0.18 11.9 0.0 1.6 1 0 0 1 1 1 0 Transferrin receptor-like dimerisation domain AAA PF00004.29 EXF79213.1 - 4.5e-18 65.9 0.0 8.3e-18 65.1 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EXF79213.1 - 0.00031 21.2 0.0 0.00089 19.7 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain RuvB_N PF05496.12 EXF79213.1 - 0.0026 17.5 0.0 0.0052 16.5 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 EXF79213.1 - 0.0054 17.3 0.1 0.29 11.7 0.0 3.3 3 0 0 3 3 3 1 AAA domain AAA_22 PF13401.6 EXF79213.1 - 0.0077 16.5 0.1 0.039 14.2 0.0 2.1 2 1 0 2 2 2 1 AAA domain AAA_5 PF07728.14 EXF79213.1 - 0.04 13.9 0.1 0.13 12.3 0.0 1.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 EXF79213.1 - 0.05 13.7 0.0 0.39 10.8 0.0 2.2 1 1 0 1 1 1 0 AAA domain (Cdc48 subfamily) AAA_17 PF13207.6 EXF79213.1 - 0.092 13.2 0.0 0.26 11.7 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EXF79213.1 - 0.11 12.7 0.0 0.24 11.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 EXF79213.1 - 0.48 10.2 2.9 1.1 9.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain NPR3 PF03666.13 EXF79213.1 - 5.5 5.7 7.0 88 1.7 0.0 2.3 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 CBM_20 PF00686.19 EXF79214.1 - 1.2e-33 114.9 0.9 2.1e-33 114.1 0.9 1.4 1 0 0 1 1 1 1 Starch binding domain LPMO_10 PF03067.15 EXF79214.1 - 4.3e-11 43.9 3.2 4.3e-11 43.9 3.2 1.9 2 0 0 2 2 2 1 Lytic polysaccharide mono-oxygenase, cellulose-degrading Glyco_hydro_61 PF03443.14 EXF79214.1 - 0.00022 21.2 0.2 0.0013 18.7 0.1 2.1 2 0 0 2 2 2 1 Glycosyl hydrolase family 61 DUF4199 PF13858.6 EXF79215.1 - 2.2 8.6 6.9 0.83 10.0 1.2 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF4199) DUF805 PF05656.14 EXF79215.1 - 2.6 8.5 14.7 1.7 9.1 12.2 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF805) Abhydrolase_6 PF12697.7 EXF79216.1 - 2.6e-06 28.2 0.0 3.2e-05 24.6 0.0 2.2 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S8 PF00082.22 EXF79217.1 - 3.2e-52 177.7 0.0 5.9e-52 176.8 0.0 1.4 1 1 0 1 1 1 1 Subtilase family fn3_5 PF06280.12 EXF79217.1 - 7e-10 39.6 0.0 2e-09 38.2 0.0 1.8 1 0 0 1 1 1 1 Fn3-like domain Inhibitor_I9 PF05922.16 EXF79217.1 - 0.17 12.6 0.0 0.38 11.4 0.0 1.6 1 0 0 1 1 1 0 Peptidase inhibitor I9 BNR_2 PF13088.6 EXF79218.1 - 0.0033 16.8 0.0 0.0093 15.3 0.0 1.8 1 1 0 1 1 1 1 BNR repeat-like domain BNR PF02012.20 EXF79218.1 - 0.01 15.7 5.2 0.82 9.9 0.0 3.8 4 0 0 4 4 4 0 BNR/Asp-box repeat Sortilin-Vps10 PF15902.5 EXF79218.1 - 0.075 11.8 0.2 9.5 4.9 0.1 2.8 3 1 1 4 4 4 0 Sortilin, neurotensin receptor 3, Glyco_hydro_35 PF01301.19 EXF79219.1 - 2.7e-90 303.2 1.1 4.1e-90 302.6 1.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 BetaGal_dom2 PF10435.9 EXF79219.1 - 1.7e-60 203.9 6.1 3.7e-60 202.9 6.1 1.5 1 0 0 1 1 1 1 Beta-galactosidase, domain 2 BetaGal_dom4_5 PF13364.6 EXF79219.1 - 1.4e-58 196.4 5.2 5.5e-31 107.5 0.0 3.0 2 0 0 2 2 2 2 Beta-galactosidase jelly roll domain BetaGal_dom3 PF13363.6 EXF79219.1 - 6.5e-21 73.7 2.3 1.3e-20 72.8 0.0 2.6 3 0 0 3 3 3 1 Beta-galactosidase, domain 3 fn3 PF00041.21 EXF79219.1 - 0.073 13.4 0.2 5.4 7.4 0.0 3.0 2 0 0 2 2 2 0 Fibronectin type III domain Glyco_hydro_28 PF00295.17 EXF79220.1 - 2.5e-115 385.0 21.7 3.1e-115 384.7 21.7 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 Cro PF09048.10 EXF79220.1 - 0.16 12.0 0.2 0.37 10.8 0.2 1.6 1 0 0 1 1 1 0 Cro MFS_1 PF07690.16 EXF79221.1 - 1.8e-22 79.8 43.8 2.4e-16 59.6 30.9 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily HSP70 PF00012.20 EXF79221.1 - 4.9e-13 48.1 0.2 8.7e-10 37.4 0.2 3.1 2 1 0 2 2 2 2 Hsp70 protein PUCC PF03209.15 EXF79221.1 - 0.00027 20.1 4.2 0.0029 16.7 3.3 2.4 2 0 0 2 2 2 1 PUCC protein FGGY_C PF02782.16 EXF79221.1 - 0.049 13.4 0.0 0.097 12.4 0.0 1.5 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, C-terminal domain NTP_transf_7 PF07984.12 EXF79221.1 - 0.15 11.3 0.0 0.23 10.6 0.0 1.2 1 0 0 1 1 1 0 Nucleotidyltransferase TPR_MLP1_2 PF07926.12 EXF79222.1 - 0.00023 21.2 4.1 0.00045 20.3 4.1 1.3 1 0 0 1 1 1 1 TPR/MLP1/MLP2-like protein Tropomyosin PF00261.20 EXF79222.1 - 0.0019 17.6 4.7 0.0033 16.9 4.7 1.3 1 0 0 1 1 1 1 Tropomyosin Jnk-SapK_ap_N PF09744.9 EXF79222.1 - 0.0045 17.2 2.7 0.0082 16.4 2.7 1.4 1 0 0 1 1 1 1 JNK_SAPK-associated protein-1 DUF4407 PF14362.6 EXF79222.1 - 0.012 15.0 0.2 0.019 14.4 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) CCDC144C PF14915.6 EXF79222.1 - 0.04 13.0 1.8 0.065 12.4 1.8 1.2 1 0 0 1 1 1 0 CCDC144C protein coiled-coil region SIKE PF05769.11 EXF79222.1 - 0.047 13.6 4.9 0.044 13.7 3.4 1.6 2 0 0 2 2 2 0 SIKE family Fez1 PF06818.15 EXF79222.1 - 0.061 13.8 1.1 0.11 12.9 1.1 1.4 1 0 0 1 1 1 0 Fez1 SHE3 PF17078.5 EXF79222.1 - 0.062 13.0 0.3 0.12 12.1 0.3 1.5 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 Herpes_BLRF2 PF05812.12 EXF79222.1 - 0.065 13.4 0.7 0.13 12.4 0.0 1.9 2 0 0 2 2 2 0 Herpesvirus BLRF2 protein TBK1_CCD1 PF18394.1 EXF79222.1 - 0.071 12.7 0.6 0.12 11.9 0.6 1.3 1 0 0 1 1 1 0 TANK-binding kinase 1 coiled-coil domain 1 GIT_CC PF16559.5 EXF79222.1 - 0.09 12.6 0.0 0.21 11.5 0.0 1.6 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor Atg14 PF10186.9 EXF79222.1 - 0.1 11.7 0.8 0.15 11.1 0.8 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF724 PF05266.14 EXF79222.1 - 0.11 12.3 1.3 0.24 11.2 1.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF724) Cep57_CLD_2 PF14197.6 EXF79222.1 - 0.11 12.5 2.7 6.9 6.8 0.2 2.6 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 Phage_GP20 PF06810.11 EXF79222.1 - 0.15 11.9 1.0 0.31 10.9 0.4 1.8 1 1 0 1 1 1 0 Phage minor structural protein GP20 DivIC PF04977.15 EXF79222.1 - 0.17 11.7 1.8 0.81 9.5 0.1 2.2 2 0 0 2 2 2 0 Septum formation initiator Lebercilin PF15619.6 EXF79222.1 - 0.18 11.4 7.3 0.71 9.5 0.3 2.2 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease KASH_CCD PF14662.6 EXF79222.1 - 0.18 11.6 3.0 0.43 10.4 3.0 1.5 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH CENP-F_leu_zip PF10473.9 EXF79222.1 - 0.19 11.7 4.2 0.41 10.7 4.2 1.5 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 BST2 PF16716.5 EXF79222.1 - 0.34 11.5 2.8 1.2 9.8 2.8 1.9 1 1 0 1 1 1 0 Bone marrow stromal antigen 2 Seryl_tRNA_N PF02403.22 EXF79222.1 - 0.59 10.4 3.6 1.4 9.2 3.6 1.6 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain ZapB PF06005.12 EXF79222.1 - 1 9.8 5.7 15 6.1 5.7 2.3 1 1 0 1 1 1 0 Cell division protein ZapB DUF4200 PF13863.6 EXF79222.1 - 1.4 9.3 6.0 24 5.3 6.0 2.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) GAS PF13851.6 EXF79222.1 - 1.6 8.0 8.2 1.2 8.4 0.4 2.5 2 1 1 3 3 2 0 Growth-arrest specific micro-tubule binding Cnn_1N PF07989.11 EXF79222.1 - 1.9 8.7 5.0 10 6.4 5.0 2.2 1 1 0 1 1 1 0 Centrosomin N-terminal motif 1 XhlA PF10779.9 EXF79222.1 - 2.6 8.3 7.2 8.9 6.6 0.2 3.2 2 1 1 3 3 3 0 Haemolysin XhlA IBR PF01485.21 EXF79223.1 - 1.7e-14 53.8 19.8 2.7e-10 40.3 1.4 4.0 3 2 0 3 3 3 2 IBR domain, a half RING-finger domain zf-C3HC4 PF00097.25 EXF79223.1 - 0.021 14.7 0.3 0.021 14.7 0.3 3.9 4 0 0 4 4 4 0 Zinc finger, C3HC4 type (RING finger) zinc_ribbon_12 PF11331.8 EXF79223.1 - 0.039 13.8 2.9 0.15 11.9 1.0 2.6 2 0 0 2 2 2 0 Probable zinc-ribbon domain zf-C3HC4_2 PF13923.6 EXF79223.1 - 0.047 13.5 0.5 0.047 13.5 0.5 4.4 4 1 0 4 4 4 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EXF79223.1 - 5.2 7.2 20.3 9 6.4 6.1 3.8 3 1 0 3 3 3 0 RING-type zinc-finger ABC_membrane_2 PF06472.15 EXF79224.1 - 4.2e-103 344.4 0.4 4.2e-103 344.4 0.4 1.4 2 0 0 2 2 2 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 EXF79224.1 - 1.5e-17 64.4 0.0 3.3e-17 63.3 0.0 1.6 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 EXF79224.1 - 0.00019 21.4 0.1 0.00056 19.8 0.0 1.8 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 EXF79224.1 - 0.011 16.1 0.5 0.39 11.1 0.0 2.5 2 0 0 2 2 2 0 AAA ATPase domain AAA_23 PF13476.6 EXF79224.1 - 0.021 15.3 0.0 0.15 12.6 0.0 2.1 2 0 0 2 2 2 0 AAA domain SMC_N PF02463.19 EXF79224.1 - 0.08 12.4 0.0 0.25 10.8 0.0 1.8 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EXF79224.1 - 0.084 12.6 0.0 0.18 11.5 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain RuvB_N PF05496.12 EXF79224.1 - 0.12 12.1 0.0 0.33 10.7 0.0 1.7 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain Rad17 PF03215.15 EXF79224.1 - 0.15 12.0 0.0 0.3 11.0 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain zf-CSL PF05207.13 EXF79225.1 - 3.6e-23 81.0 0.7 4.9e-23 80.6 0.7 1.2 1 0 0 1 1 1 1 CSL zinc finger Zn-ribbon_8 PF09723.10 EXF79225.1 - 2.2e-05 24.5 0.6 3.4e-05 23.9 0.6 1.3 1 0 0 1 1 1 1 Zinc ribbon domain Terminase_GpA PF05876.12 EXF79225.1 - 0.032 12.8 0.1 0.037 12.6 0.1 1.1 1 0 0 1 1 1 0 Phage terminase large subunit (GpA) Prok-RING_1 PF14446.6 EXF79225.1 - 0.32 11.0 3.5 0.68 9.9 3.5 1.6 1 1 0 1 1 1 0 Prokaryotic RING finger family 1 tRNA-synt_1 PF00133.22 EXF79227.1 - 6.9e-36 123.7 0.0 6.7e-26 90.7 0.0 3.1 2 1 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 EXF79227.1 - 2.9e-15 55.9 0.1 1.6e-08 33.7 0.0 2.8 3 0 0 3 3 3 2 tRNA synthetases class I (M) Anticodon_1 PF08264.13 EXF79227.1 - 6.6e-11 42.4 3.0 8e-11 42.1 1.9 1.8 1 1 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.19 EXF79227.1 - 7.5e-08 32.1 0.0 1.7e-07 30.9 0.0 1.6 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain Tenui_NS4 PF03300.13 EXF79228.1 - 0.17 11.3 0.0 0.21 10.9 0.0 1.1 1 0 0 1 1 1 0 Tenuivirus non-structural, movement protein NS4 Clat_adaptor_s PF01217.20 EXF79229.1 - 1.1e-42 145.4 0.0 2.1e-42 144.4 0.0 1.4 1 1 0 1 1 1 1 Clathrin adaptor complex small chain Frataxin_Cyay PF01491.16 EXF79230.1 - 1.7e-37 127.8 0.0 2.3e-37 127.4 0.0 1.1 1 0 0 1 1 1 1 Frataxin-like domain AJAP1_PANP_C PF15298.6 EXF79231.1 - 0.077 13.2 0.0 0.11 12.7 0.0 1.3 1 0 0 1 1 1 0 AJAP1/PANP C-terminus DUF4448 PF14610.6 EXF79231.1 - 0.14 11.9 0.0 0.26 11.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) MDMPI_C PF07398.11 EXF79231.1 - 6.5 7.7 7.7 20 6.1 4.2 2.6 1 1 1 2 2 2 0 MDMPI C-terminal domain Zn_clus PF00172.18 EXF79232.1 - 2.2e-08 34.1 9.3 4.2e-08 33.2 9.3 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EXF79232.1 - 0.0014 17.5 0.1 0.0023 16.8 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain RTA1 PF04479.13 EXF79233.1 - 1.9e-65 220.4 9.9 1.9e-65 220.4 9.9 1.6 1 1 1 2 2 2 1 RTA1 like protein Gly-zipper_Omp PF13488.6 EXF79234.1 - 0.0028 17.6 15.2 0.0028 17.6 15.2 2.3 1 1 1 2 2 2 1 Glycine zipper Borrelia_P83 PF05262.11 EXF79234.1 - 0.0077 14.8 2.0 0.0075 14.8 2.0 1.2 1 0 0 1 1 1 1 Borrelia P83/100 protein Presenilin PF01080.17 EXF79234.1 - 0.018 13.9 0.2 0.022 13.5 0.2 1.2 1 0 0 1 1 1 0 Presenilin Gly-zipper_OmpA PF13436.6 EXF79234.1 - 0.022 14.5 17.1 0.022 14.5 17.1 2.5 1 1 1 2 2 2 0 Glycine-zipper domain SAPS PF04499.15 EXF79234.1 - 0.08 11.7 0.2 0.087 11.6 0.2 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Keratin_2_head PF16208.5 EXF79234.1 - 0.097 12.8 11.7 0.14 12.3 11.7 1.2 1 0 0 1 1 1 0 Keratin type II head Sporozoite_P67 PF05642.11 EXF79234.1 - 0.12 10.5 11.1 0.14 10.2 11.1 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen CbtA PF09490.10 EXF79234.1 - 0.2 11.4 6.7 0.064 13.0 4.3 1.5 1 1 0 1 1 1 0 Probable cobalt transporter subunit (CbtA) Hid1 PF12722.7 EXF79234.1 - 0.27 9.3 0.2 0.33 9.0 0.2 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF3292 PF11696.8 EXF79234.1 - 0.34 9.2 4.2 0.4 9.0 4.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) Spore_II_R PF09551.10 EXF79234.1 - 0.57 10.6 4.3 0.85 10.1 4.3 1.3 1 0 0 1 1 1 0 Stage II sporulation protein R (spore_II_R) TP53IP5 PF15331.6 EXF79234.1 - 1.4 9.1 7.3 2.3 8.3 7.3 1.2 1 0 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 CR6_interact PF10147.9 EXF79234.1 - 1.8 8.2 14.8 3.3 7.4 14.8 1.4 1 0 0 1 1 1 0 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 Gly-zipper_YMGG PF13441.6 EXF79234.1 - 2.3 8.0 37.7 3.5e+03 -2.2 37.7 2.3 1 1 0 1 1 1 0 YMGG-like Gly-zipper DUF2992 PF11208.8 EXF79234.1 - 6.4 7.0 15.4 12 6.1 15.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2992) Cu_bind_like PF02298.17 EXF79235.1 - 0.052 13.6 0.1 0.14 12.1 0.1 1.7 1 1 0 1 1 1 0 Plastocyanin-like domain Glyco_hydro_43 PF04616.14 EXF79236.1 - 5.6e-52 176.8 7.5 1.2e-27 96.9 0.5 2.1 1 1 1 2 2 2 2 Glycosyl hydrolases family 43 GH43_C2 PF17851.1 EXF79236.1 - 5.8e-24 85.0 0.0 9.3e-24 84.3 0.0 1.3 1 0 0 1 1 1 1 Beta xylosidase C-terminal Concanavalin A-like domain GST_N_3 PF13417.6 EXF79237.1 - 1.9e-18 66.6 0.0 3.8e-18 65.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EXF79237.1 - 3.9e-17 62.3 0.2 8.6e-17 61.2 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 EXF79237.1 - 9.9e-07 29.0 0.1 2.1e-06 28.0 0.1 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EXF79237.1 - 4e-06 26.8 0.2 8.2e-06 25.8 0.2 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_5 PF16865.5 EXF79237.1 - 0.0014 19.1 0.0 0.0027 18.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EXF79237.1 - 0.024 14.8 0.0 0.053 13.7 0.0 1.6 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EXF79237.1 - 0.12 12.6 0.0 0.25 11.6 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Pro_dh PF01619.18 EXF79238.1 - 4.8e-61 206.9 0.0 5.6e-61 206.7 0.0 1.1 1 0 0 1 1 1 1 Proline dehydrogenase P5CR_dimer PF14748.6 EXF79239.1 - 6.3e-29 100.3 2.0 1.1e-28 99.4 0.8 2.1 3 0 0 3 3 3 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.17 EXF79239.1 - 3.1e-15 56.5 0.1 7e-15 55.4 0.1 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Sacchrp_dh_NADP PF03435.18 EXF79239.1 - 0.058 13.6 0.0 0.13 12.5 0.0 1.6 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain ThiF PF00899.21 EXF79239.1 - 0.072 12.4 0.2 1 8.6 0.1 2.2 2 0 0 2 2 2 0 ThiF family DUF1772 PF08592.11 EXF79240.1 - 0.025 14.9 3.8 0.049 13.9 3.8 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1772) MFS_MOT1 PF16983.5 EXF79240.1 - 0.56 10.6 3.8 3.7 8.0 0.1 2.4 1 1 1 2 2 2 0 Molybdate transporter of MFS superfamily Aldedh PF00171.22 EXF79241.1 - 7.3e-99 331.3 0.0 9e-99 331.0 0.0 1.1 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DAO PF01266.24 EXF79242.1 - 6.8e-30 104.8 0.0 8.2e-30 104.6 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EXF79242.1 - 2.3e-07 30.9 0.0 9.3e-07 29.0 0.0 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 EXF79242.1 - 0.00024 20.4 0.1 0.015 14.6 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EXF79242.1 - 0.002 17.4 0.0 1.4 8.1 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EXF79242.1 - 0.0034 16.5 0.0 0.62 9.1 0.0 2.1 2 0 0 2 2 2 2 FAD binding domain GIDA PF01134.22 EXF79242.1 - 0.0049 16.0 0.3 0.076 12.1 0.2 2.1 2 0 0 2 2 2 1 Glucose inhibited division protein A NAD_binding_9 PF13454.6 EXF79242.1 - 0.0081 16.2 0.0 0.92 9.5 0.0 2.3 2 0 0 2 2 2 1 FAD-NAD(P)-binding HI0933_like PF03486.14 EXF79242.1 - 0.023 13.4 0.1 1.6 7.3 0.0 2.2 2 0 0 2 2 2 0 HI0933-like protein FAD_binding_3 PF01494.19 EXF79242.1 - 0.032 13.5 0.0 0.21 10.8 0.0 2.0 2 0 0 2 2 2 0 FAD binding domain Lycopene_cycl PF05834.12 EXF79242.1 - 0.041 12.9 0.2 3.1 6.7 0.1 2.4 2 0 0 2 2 2 0 Lycopene cyclase protein Thi4 PF01946.17 EXF79242.1 - 0.043 13.0 0.2 0.1 11.8 0.0 1.6 2 0 0 2 2 2 0 Thi4 family K_oxygenase PF13434.6 EXF79242.1 - 0.071 12.2 0.0 7.9 5.5 0.0 2.2 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) TrkA_N PF02254.18 EXF79242.1 - 0.12 12.6 0.0 0.38 11.0 0.0 1.9 2 0 0 2 2 2 0 TrkA-N domain Fungal_trans PF04082.18 EXF79243.1 - 1.3e-15 57.2 1.0 2.1e-15 56.5 1.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF79243.1 - 2.9e-06 27.3 13.6 2.9e-06 27.3 13.6 2.0 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Aa_trans PF01490.18 EXF79244.1 - 7.8e-42 143.4 28.3 8.8e-42 143.2 28.3 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Pro_racemase PF05544.11 EXF79245.1 - 2.6e-125 417.8 0.1 2.9e-125 417.6 0.1 1.0 1 0 0 1 1 1 1 Proline racemase PhzC-PhzF PF02567.16 EXF79245.1 - 0.0014 18.2 0.0 0.0025 17.3 0.0 1.3 1 0 0 1 1 1 1 Phenazine biosynthesis-like protein OCD_Mu_crystall PF02423.15 EXF79246.1 - 1.8e-13 50.1 0.1 1.3e-11 44.0 0.1 2.8 1 1 0 1 1 1 1 Ornithine cyclodeaminase/mu-crystallin family Shikimate_DH PF01488.20 EXF79246.1 - 1.3e-09 38.2 0.0 1.8e-06 28.1 0.0 3.1 2 1 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase DUF3530 PF12048.8 EXF79246.1 - 0.083 12.3 0.0 0.12 11.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3530) GFO_IDH_MocA PF01408.22 EXF79246.1 - 0.12 13.2 0.0 0.29 12.0 0.0 1.6 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold p450 PF00067.22 EXF79247.1 - 1.3e-70 238.5 0.0 1.7e-70 238.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Fungal_trans PF04082.18 EXF79248.1 - 1.1e-26 93.5 1.0 8.6e-16 57.8 0.0 2.5 2 0 0 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF79248.1 - 4.9e-09 36.2 23.6 2.6e-08 33.9 9.7 2.6 3 0 0 3 3 3 2 Fungal Zn(2)-Cys(6) binuclear cluster domain YqjK PF13997.6 EXF79248.1 - 0.14 12.5 0.4 15 5.9 0.2 2.6 2 0 0 2 2 2 0 YqjK-like protein DUF5079 PF16882.5 EXF79248.1 - 0.22 11.4 0.0 7.8 6.3 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF5079) ABC2_membrane PF01061.24 EXF79249.1 - 4.6e-76 254.9 60.4 5e-41 140.4 24.6 3.5 4 0 0 4 4 3 2 ABC-2 type transporter PDR_CDR PF06422.12 EXF79249.1 - 8.2e-35 118.6 1.2 3.5e-31 107.0 0.0 3.4 2 0 0 2 2 2 2 CDR ABC transporter ABC_tran PF00005.27 EXF79249.1 - 3.8e-34 118.1 0.0 3.1e-16 60.1 0.0 2.4 2 0 0 2 2 2 2 ABC transporter ABC_trans_N PF14510.6 EXF79249.1 - 2.6e-15 56.8 0.0 7.7e-15 55.3 0.0 1.8 1 0 0 1 1 1 1 ABC-transporter N-terminal ABC2_membrane_3 PF12698.7 EXF79249.1 - 3.3e-06 26.5 11.4 3.3e-06 26.5 11.4 3.0 3 0 0 3 3 3 2 ABC-2 family transporter protein AAA_16 PF13191.6 EXF79249.1 - 4.5e-05 23.9 0.1 0.22 11.9 0.1 2.4 2 0 0 2 2 2 2 AAA ATPase domain AAA_33 PF13671.6 EXF79249.1 - 0.00015 21.9 0.4 0.064 13.4 0.0 3.3 3 0 0 3 3 3 1 AAA domain RsgA_GTPase PF03193.16 EXF79249.1 - 0.00016 21.6 0.1 0.011 15.7 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase SMC_N PF02463.19 EXF79249.1 - 0.00029 20.3 0.0 0.033 13.6 0.0 3.1 3 0 0 3 3 3 1 RecF/RecN/SMC N terminal domain AAA_25 PF13481.6 EXF79249.1 - 0.00038 20.1 0.3 0.001 18.7 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 EXF79249.1 - 0.00041 20.0 1.2 0.031 14.0 0.1 2.4 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_18 PF13238.6 EXF79249.1 - 0.00048 20.7 0.1 0.068 13.7 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_21 PF13304.6 EXF79249.1 - 0.00095 19.1 1.0 0.92 9.3 0.1 2.5 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 EXF79249.1 - 0.0043 17.3 1.2 2.2 8.6 0.2 2.6 2 0 0 2 2 2 1 AAA domain cobW PF02492.19 EXF79249.1 - 0.021 14.4 2.5 0.14 11.8 0.1 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_28 PF13521.6 EXF79249.1 - 0.033 14.5 0.3 1 9.6 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.6 EXF79249.1 - 0.045 14.2 0.6 3.2 8.2 0.0 2.6 2 0 0 2 2 2 0 AAA domain T2SSE PF00437.20 EXF79249.1 - 0.045 12.8 0.2 1.8 7.5 0.0 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein Zeta_toxin PF06414.12 EXF79249.1 - 0.058 12.7 0.9 0.21 10.9 0.0 2.0 2 0 0 2 2 2 0 Zeta toxin AAA_23 PF13476.6 EXF79249.1 - 0.079 13.5 0.0 0.15 12.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 EXF79249.1 - 0.1 12.3 0.5 2.8 7.6 0.0 2.7 3 0 0 3 3 2 0 AAA domain PDR_assoc PF08370.11 EXF79249.1 - 0.68 9.7 10.2 2 8.2 0.7 3.7 3 0 0 3 3 3 0 Plant PDR ABC transporter associated NACHT PF05729.12 EXF79249.1 - 1.5 8.8 4.5 6.8 6.6 0.2 2.8 3 0 0 3 3 3 0 NACHT domain Bac_luciferase PF00296.20 EXF79250.1 - 5.4e-68 229.7 0.0 6.6e-68 229.5 0.0 1.0 1 0 0 1 1 1 1 Luciferase-like monooxygenase GMC_oxred_N PF00732.19 EXF79252.1 - 2.2e-40 138.9 0.5 5.2e-22 78.6 0.0 2.2 1 1 1 2 2 2 2 GMC oxidoreductase GMC_oxred_C PF05199.13 EXF79252.1 - 3.6e-36 124.8 0.0 5.6e-36 124.2 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase DAO PF01266.24 EXF79252.1 - 0.0035 17.0 0.2 0.0073 15.9 0.1 1.6 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EXF79252.1 - 0.0055 16.0 0.0 0.009 15.3 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EXF79252.1 - 0.008 16.4 0.4 0.02 15.1 0.4 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 EXF79252.1 - 0.029 13.4 0.1 0.057 12.5 0.1 1.4 1 0 0 1 1 1 0 Lycopene cyclase protein NAD_binding_9 PF13454.6 EXF79252.1 - 0.13 12.3 0.1 0.22 11.5 0.1 1.4 1 0 0 1 1 1 0 FAD-NAD(P)-binding Pyr_redox_3 PF13738.6 EXF79252.1 - 0.13 11.5 0.1 0.99 8.6 0.1 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Zn_clus PF00172.18 EXF79253.1 - 0.018 15.2 0.2 0.028 14.5 0.2 1.3 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain AMP-binding PF00501.28 EXF79254.1 - 1.8e-160 534.2 0.0 1.3e-79 267.8 0.1 2.3 2 0 0 2 2 2 2 AMP-binding enzyme Condensation PF00668.20 EXF79254.1 - 3.8e-40 137.9 0.0 1.2e-36 126.4 0.0 2.4 2 0 0 2 2 2 2 Condensation domain NAD_binding_4 PF07993.12 EXF79254.1 - 3.5e-39 134.5 0.0 6.7e-39 133.6 0.0 1.4 1 0 0 1 1 1 1 Male sterility protein PP-binding PF00550.25 EXF79254.1 - 1.5e-17 63.7 1.4 1.5e-10 41.3 0.0 3.2 3 0 0 3 3 3 2 Phosphopantetheine attachment site Epimerase PF01370.21 EXF79254.1 - 2.1e-08 33.9 0.0 4.4e-08 32.9 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GFA PF04828.14 EXF79254.1 - 2.6e-05 24.5 0.0 0.0037 17.6 0.0 2.9 1 1 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme 3Beta_HSD PF01073.19 EXF79254.1 - 0.0011 18.1 0.1 0.011 14.8 0.0 2.5 2 1 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family MFS_1 PF07690.16 EXF79255.1 - 1.9e-40 138.9 41.0 1.9e-40 138.9 41.0 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF79255.1 - 4.4e-09 35.7 3.4 4.4e-09 35.7 3.4 3.2 2 1 1 3 3 3 1 Sugar (and other) transporter TRI12 PF06609.13 EXF79255.1 - 2.2e-08 33.0 14.4 3.5e-08 32.4 14.4 1.4 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) OATP PF03137.20 EXF79255.1 - 0.0026 16.1 0.8 0.0026 16.1 0.8 1.9 2 0 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family DUF5056 PF16479.5 EXF79255.1 - 0.16 12.3 0.1 0.16 12.3 0.1 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF5056) 7tm_1 PF00001.21 EXF79255.1 - 0.43 9.9 3.2 0.27 10.5 0.8 1.8 2 0 0 2 2 2 0 7 transmembrane receptor (rhodopsin family) FAD_binding_4 PF01565.23 EXF79256.1 - 7.8e-17 61.3 0.0 1.7e-16 60.3 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain Cupin_2 PF07883.11 EXF79257.1 - 3.1e-05 23.6 0.1 5.3e-05 22.9 0.1 1.3 1 0 0 1 1 1 1 Cupin domain Cupin_1 PF00190.22 EXF79257.1 - 0.00014 21.5 0.0 0.00023 20.8 0.0 1.4 1 1 0 1 1 1 1 Cupin Cupin_6 PF12852.7 EXF79257.1 - 0.012 15.3 0.0 0.015 15.0 0.0 1.1 1 0 0 1 1 1 0 Cupin ARD PF03079.14 EXF79257.1 - 0.032 14.4 0.0 0.045 13.9 0.0 1.2 1 0 0 1 1 1 0 ARD/ARD' family DUF829 PF05705.14 EXF79258.1 - 4e-50 171.0 0.0 4.6e-50 170.8 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF829) 4HBT_3 PF13622.6 EXF79259.1 - 2.5e-49 168.8 0.1 2.9e-49 168.6 0.1 1.0 1 0 0 1 1 1 1 Thioesterase-like superfamily Ala_racemase_N PF01168.20 EXF79260.1 - 1.9e-27 96.3 0.0 2.5e-27 96.0 0.0 1.1 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain D-ser_dehydrat PF14031.6 EXF79260.1 - 5.6e-23 81.4 0.0 1.2e-22 80.4 0.0 1.6 1 0 0 1 1 1 1 Putative serine dehydratase domain GTP_CH_N PF12471.8 EXF79260.1 - 0.024 14.4 0.0 0.053 13.3 0.0 1.5 1 0 0 1 1 1 0 GTP cyclohydrolase N terminal RuvX PF03652.15 EXF79260.1 - 0.045 14.1 0.1 0.27 11.6 0.0 2.2 2 0 0 2 2 2 0 Holliday junction resolvase p450 PF00067.22 EXF79261.1 - 2.1e-48 165.3 0.0 2.6e-48 164.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 D-ser_dehydrat PF14031.6 EXF79262.1 - 1e-23 83.8 0.0 2.4e-23 82.6 0.0 1.7 1 0 0 1 1 1 1 Putative serine dehydratase domain Ala_racemase_N PF01168.20 EXF79262.1 - 7.5e-16 58.4 0.0 1e-15 58.0 0.0 1.1 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain Cpn10 PF00166.21 EXF79262.1 - 0.038 14.0 0.6 0.088 12.9 0.2 1.8 2 0 0 2 2 2 0 Chaperonin 10 Kd subunit Fungal_trans_2 PF11951.8 EXF79263.1 - 6.7e-42 143.7 5.5 9.2e-42 143.2 5.5 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF79263.1 - 2.6e-07 30.7 12.9 4e-07 30.0 12.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TMEM154 PF15102.6 EXF79266.1 - 0.00034 20.5 0.0 0.00055 19.9 0.0 1.5 1 0 0 1 1 1 1 TMEM154 protein family SKG6 PF08693.10 EXF79266.1 - 0.00035 19.9 0.1 0.00035 19.9 0.1 1.8 2 0 0 2 2 2 1 Transmembrane alpha-helix domain MGC-24 PF05283.11 EXF79266.1 - 0.0012 19.3 9.4 0.0012 19.3 9.4 2.1 2 0 0 2 2 2 1 Multi-glycosylated core protein 24 (MGC-24), sialomucin Glycophorin_A PF01102.18 EXF79266.1 - 0.004 17.4 0.5 0.0084 16.3 0.5 1.5 1 0 0 1 1 1 1 Glycophorin A DUF1633 PF07794.11 EXF79266.1 - 1.9 6.6 8.4 2.3 6.3 8.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1633) FSA_C PF10479.9 EXF79266.1 - 7.7 4.5 18.3 10 4.1 18.3 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus DDDD PF10161.9 EXF79267.1 - 0.15 11.9 1.1 6.8 6.5 0.2 2.6 2 0 0 2 2 2 0 Putative mitochondrial precursor protein LRR_2 PF07723.13 EXF79267.1 - 0.17 12.6 1.0 61 4.5 0.0 3.9 4 0 0 4 4 4 0 Leucine Rich Repeat DUF2236 PF09995.9 EXF79268.1 - 1.1e-27 97.8 0.1 1.7e-27 97.1 0.1 1.2 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2236) SNF2_N PF00176.23 EXF79270.1 - 7.3e-57 192.7 0.1 3.3e-56 190.5 0.1 1.7 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EXF79270.1 - 1.1e-12 48.3 0.0 3.2e-12 46.8 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EXF79270.1 - 0.00011 22.3 0.0 0.0002 21.4 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SWI2_SNF2 PF18766.1 EXF79270.1 - 0.002 17.8 0.0 0.11 12.2 0.0 2.2 2 0 0 2 2 2 1 SWI2/SNF2 ATPase Methyltransf_17 PF12692.7 EXF79270.1 - 0.048 13.7 0.0 0.1 12.6 0.0 1.5 1 0 0 1 1 1 0 S-adenosyl-L-methionine methyltransferase NACHT PF05729.12 EXF79271.1 - 7.5e-06 26.0 0.1 3.6e-05 23.8 0.0 2.2 2 0 0 2 2 2 1 NACHT domain AAA_22 PF13401.6 EXF79271.1 - 0.0006 20.1 1.1 0.011 16.1 0.0 3.2 3 0 0 3 3 3 1 AAA domain NB-ARC PF00931.22 EXF79271.1 - 0.0076 15.5 0.0 0.02 14.1 0.0 1.6 1 0 0 1 1 1 1 NB-ARC domain AAA_30 PF13604.6 EXF79271.1 - 0.055 13.2 0.0 1.1 8.9 0.0 2.8 3 0 0 3 3 3 0 AAA domain KAP_NTPase PF07693.14 EXF79271.1 - 0.071 12.3 0.0 24 4.0 0.0 3.1 3 0 0 3 3 3 0 KAP family P-loop domain DUF445 PF04286.12 EXF79271.1 - 0.42 10.4 2.3 0.8 9.4 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF445) AAA_16 PF13191.6 EXF79271.1 - 0.5 10.7 0.0 0.5 10.7 0.0 3.7 4 0 0 4 4 4 0 AAA ATPase domain PALP PF00291.25 EXF79272.1 - 1.1e-59 202.3 3.2 1.5e-59 201.8 3.2 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme CALCOCO1 PF07888.11 EXF79273.1 - 0.16 10.8 27.6 0.26 10.1 27.6 1.3 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like MCC-bdg_PDZ PF10506.9 EXF79273.1 - 7.1 6.7 7.8 51 4.0 0.1 4.1 4 0 0 4 4 4 0 PDZ domain of MCC-2 bdg protein for Usher syndrome DUF3453 PF11935.8 EXF79274.1 - 1.6e-70 237.3 0.1 3e-70 236.4 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3453) Sds3 PF08598.11 EXF79275.1 - 1.5e-12 48.0 8.5 1.5e-12 48.0 8.5 2.6 2 1 0 2 2 2 1 Sds3-like Metal_resist PF13801.6 EXF79275.1 - 0.23 11.7 2.7 2.6 8.3 0.9 2.8 2 0 0 2 2 2 0 Heavy-metal resistance RRM_1 PF00076.22 EXF79276.1 - 1.1e-11 44.3 0.3 2.5e-07 30.4 0.0 2.8 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RR_TM4-6 PF06459.12 EXF79276.1 - 9.5 6.0 30.5 18 5.0 30.5 1.5 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Peptidase_S64 PF08192.11 EXF79276.1 - 9.9 4.5 9.4 14 4.0 9.4 1.1 1 0 0 1 1 1 0 Peptidase family S64 Tubulin PF00091.25 EXF79277.1 - 8.5e-63 212.1 0.0 1.2e-62 211.6 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EXF79277.1 - 2.9e-45 153.5 0.0 4.3e-45 152.9 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 EXF79277.1 - 8.7e-05 22.3 0.0 0.00016 21.4 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain p450 PF00067.22 EXF79278.1 - 6.9e-39 133.9 0.0 9.8e-39 133.4 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 3Beta_HSD PF01073.19 EXF79279.1 - 5.5e-22 78.1 0.0 4.1e-21 75.2 0.0 2.0 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 EXF79279.1 - 7e-08 32.0 0.0 1.1e-07 31.4 0.0 1.2 1 0 0 1 1 1 1 Male sterility protein Epimerase PF01370.21 EXF79279.1 - 0.00017 21.1 0.0 0.00038 20.0 0.0 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family KR PF08659.10 EXF79279.1 - 0.068 13.1 0.3 0.12 12.2 0.3 1.4 1 1 0 1 1 1 0 KR domain NAD_binding_10 PF13460.6 EXF79279.1 - 0.14 12.0 0.0 0.73 9.7 0.0 2.1 1 1 0 1 1 1 0 NAD(P)H-binding PRTP PF01366.18 EXF79280.1 - 0.41 8.6 2.8 0.51 8.3 2.8 1.1 1 0 0 1 1 1 0 Herpesvirus processing and transport protein HTH_Tnp_Tc3_2 PF01498.18 EXF79282.1 - 6.2e-05 23.2 0.0 0.00026 21.2 0.0 2.0 1 0 0 1 1 1 1 Transposase HTH_32 PF13565.6 EXF79282.1 - 0.00039 21.0 1.2 0.00039 21.0 1.2 3.3 3 1 1 4 4 4 2 Homeodomain-like domain HTH_23 PF13384.6 EXF79282.1 - 0.041 13.7 0.1 0.11 12.3 0.1 1.7 1 0 0 1 1 1 0 Homeodomain-like domain HTH_7 PF02796.15 EXF79282.1 - 0.061 13.4 0.8 36 4.5 0.1 3.3 3 0 0 3 3 3 0 Helix-turn-helix domain of resolvase RNA_pol_Rpo13 PF12136.8 EXF79282.1 - 1.2 9.1 4.8 2.6 8.0 4.2 1.8 1 1 0 1 1 1 0 RNA polymerase Rpo13 subunit HTH domain Cupin_2 PF07883.11 EXF79283.1 - 3.1e-07 30.0 0.0 5.6e-07 29.2 0.0 1.4 1 0 0 1 1 1 1 Cupin domain Cupin_3 PF05899.12 EXF79283.1 - 0.053 13.2 0.0 0.096 12.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF861) GFO_IDH_MocA PF01408.22 EXF79284.1 - 3.6e-11 43.9 0.0 8.2e-11 42.8 0.0 1.6 1 1 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 EXF79284.1 - 0.00046 20.2 0.0 0.00094 19.2 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain ImpA_N PF06812.12 EXF79284.1 - 0.12 12.5 0.0 0.36 10.9 0.0 1.9 1 0 0 1 1 1 0 ImpA, N-terminal, type VI secretion system RNase_T PF00929.24 EXF79285.1 - 5.8e-28 98.5 0.0 6.9e-28 98.3 0.0 1.1 1 0 0 1 1 1 1 Exonuclease PGM_PMM_I PF02878.16 EXF79286.1 - 8.5e-33 113.0 0.0 1.3e-32 112.4 0.0 1.3 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.16 EXF79286.1 - 1.2e-25 89.9 0.0 2.5e-25 88.9 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 EXF79286.1 - 5.9e-16 59.0 0.0 1.4e-15 57.8 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.20 EXF79286.1 - 1.2e-06 28.5 0.0 2.6e-06 27.5 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain DUF4844 PF16133.5 EXF79286.1 - 0.13 12.8 0.2 0.64 10.6 0.3 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4844) HMG_box PF00505.19 EXF79288.1 - 9.3e-25 86.8 0.8 1.7e-24 86.0 0.8 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EXF79288.1 - 1.6e-17 63.9 1.2 1.6e-17 63.9 1.2 1.5 2 0 0 2 2 2 1 HMG-box domain Ccdc124 PF06244.12 EXF79288.1 - 0.0016 19.0 0.0 0.0016 19.0 0.0 2.1 1 1 1 2 2 2 1 Coiled-coil domain-containing protein 124 /Oxs1 CHDNT PF08073.12 EXF79288.1 - 0.059 13.3 0.0 0.095 12.7 0.0 1.3 1 0 0 1 1 1 0 CHDNT (NUC034) domain CENP-H PF05837.12 EXF79289.1 - 1.6e-37 128.4 8.0 1.9e-37 128.1 3.0 2.1 2 0 0 2 2 2 1 Centromere protein H (CENP-H) TMF_TATA_bd PF12325.8 EXF79289.1 - 0.013 15.7 3.5 0.013 15.7 3.5 2.1 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding DUF1192 PF06698.11 EXF79289.1 - 0.093 12.8 3.1 6.1 7.0 0.4 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) TMCO5 PF14992.6 EXF79289.1 - 0.098 12.2 2.0 0.13 11.8 0.4 1.8 2 0 0 2 2 2 0 TMCO5 family CCDC53 PF10152.9 EXF79289.1 - 0.36 11.3 2.5 0.72 10.3 2.5 1.5 1 1 0 1 1 1 0 Subunit CCDC53 of WASH complex ERM PF00769.19 EXF79289.1 - 0.84 9.4 7.8 0.94 9.2 5.1 2.0 2 0 0 2 2 2 0 Ezrin/radixin/moesin family GvpL_GvpF PF06386.11 EXF79289.1 - 1.6 8.6 7.4 2.4 8.0 7.1 1.4 1 1 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF YabA PF06156.13 EXF79289.1 - 2.6 8.7 4.0 3.4 8.4 1.1 2.3 2 1 0 2 2 2 0 Initiation control protein YabA DHR10 PF18595.1 EXF79289.1 - 2.7 8.1 12.3 9.2 6.4 6.1 2.5 2 1 0 2 2 2 0 Designed helical repeat protein 10 domain DivIC PF04977.15 EXF79289.1 - 8.1 6.3 8.7 2.9 7.7 2.7 2.7 2 2 1 3 3 3 0 Septum formation initiator ATG11 PF10377.9 EXF79290.1 - 5.8e-46 155.7 0.2 5.8e-46 155.7 0.2 6.0 8 0 0 8 8 8 1 Autophagy-related protein 11 APG17 PF04108.12 EXF79290.1 - 0.0004 19.6 7.3 0.0004 19.6 7.3 6.1 2 2 3 5 5 5 1 Autophagy protein Apg17 Tropomyosin PF00261.20 EXF79290.1 - 0.00074 18.9 11.7 0.00074 18.9 11.7 7.2 4 1 1 6 6 6 1 Tropomyosin Macoilin PF09726.9 EXF79290.1 - 0.0015 17.2 22.8 0.0015 17.2 22.8 4.5 4 1 1 5 5 5 1 Macoilin family FERM_f0 PF16511.5 EXF79290.1 - 0.0052 17.1 0.5 3 8.2 0.0 3.4 3 0 0 3 3 3 1 N-terminal or F0 domain of Talin-head FERM TPR_MLP1_2 PF07926.12 EXF79290.1 - 0.0058 16.7 13.6 0.0058 16.7 13.6 9.8 6 2 3 10 10 10 2 TPR/MLP1/MLP2-like protein DtxR PF18357.1 EXF79290.1 - 0.086 12.5 0.9 0.18 11.5 0.9 1.6 1 0 0 1 1 1 0 Diphteria toxin repressor SH3 domain Nop14 PF04147.12 EXF79291.1 - 1.9e-05 23.1 3.6 2.8e-05 22.6 3.6 1.1 1 0 0 1 1 1 1 Nop14-like family CDC45 PF02724.14 EXF79291.1 - 0.068 11.5 6.1 0.11 10.8 6.1 1.2 1 0 0 1 1 1 0 CDC45-like protein NOA36 PF06524.12 EXF79291.1 - 1.7 7.9 12.6 2.9 7.1 12.6 1.3 1 0 0 1 1 1 0 NOA36 protein SDF PF00375.18 EXF79292.1 - 1.4e-90 304.1 32.2 1.7e-90 303.9 32.2 1.0 1 0 0 1 1 1 1 Sodium:dicarboxylate symporter family Dynamin_N PF00350.23 EXF79293.1 - 1.1e-32 113.4 0.0 2e-32 112.6 0.0 1.4 1 0 0 1 1 1 1 Dynamin family Dynamin_M PF01031.20 EXF79293.1 - 9.4e-26 90.7 0.2 2e-25 89.6 0.2 1.5 1 1 0 1 1 1 1 Dynamin central region MMR_HSR1 PF01926.23 EXF79293.1 - 0.00026 21.1 0.0 0.0011 19.0 0.0 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase ABC2_membrane PF01061.24 EXF79295.1 - 4.6e-73 245.1 64.0 2.2e-40 138.3 27.0 3.2 3 0 0 3 3 3 2 ABC-2 type transporter ABC_tran PF00005.27 EXF79295.1 - 5.5e-36 124.1 0.0 2e-17 64.0 0.0 2.7 3 0 0 3 3 2 2 ABC transporter PDR_CDR PF06422.12 EXF79295.1 - 1.9e-32 111.0 3.7 8.9e-27 92.8 0.0 3.8 3 0 0 3 3 3 2 CDR ABC transporter ABC_trans_N PF14510.6 EXF79295.1 - 1.1e-15 58.0 0.0 3.7e-15 56.3 0.0 1.9 1 0 0 1 1 1 1 ABC-transporter N-terminal ABC2_membrane_3 PF12698.7 EXF79295.1 - 1.1e-11 44.5 39.0 5.4e-08 32.3 15.2 2.4 2 0 0 2 2 2 2 ABC-2 family transporter protein AAA_16 PF13191.6 EXF79295.1 - 5e-07 30.3 0.3 0.011 16.1 0.2 2.7 2 0 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 EXF79295.1 - 2.8e-05 24.1 0.1 0.002 18.0 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_18 PF13238.6 EXF79295.1 - 3.4e-05 24.4 0.1 0.0072 16.9 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 EXF79295.1 - 6.9e-05 22.5 0.3 0.0036 16.9 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EXF79295.1 - 0.0002 21.5 0.1 0.09 12.9 0.1 3.1 3 0 0 3 3 3 1 AAA domain SMC_N PF02463.19 EXF79295.1 - 0.0013 18.2 0.0 0.36 10.2 0.0 3.3 3 1 1 4 4 4 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EXF79295.1 - 0.0016 18.4 2.3 0.97 9.2 0.0 3.3 3 1 1 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA PF00004.29 EXF79295.1 - 0.0017 18.7 0.3 0.26 11.7 0.1 2.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 EXF79295.1 - 0.0079 15.9 0.7 0.37 10.6 0.2 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain cobW PF02492.19 EXF79295.1 - 0.0087 15.7 0.5 4.3 6.9 0.1 2.3 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain AAA_30 PF13604.6 EXF79295.1 - 0.012 15.3 0.3 5.6 6.6 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 EXF79295.1 - 0.016 15.5 0.7 7.5 6.8 0.1 2.7 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 EXF79295.1 - 0.016 15.1 0.2 7.9 6.4 0.1 2.7 2 0 0 2 2 2 0 NACHT domain AAA_17 PF13207.6 EXF79295.1 - 0.042 14.3 0.4 10 6.6 0.0 3.0 3 0 0 3 3 2 0 AAA domain DUF5115 PF17142.4 EXF79295.1 - 0.074 12.7 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5115) AAA_28 PF13521.6 EXF79295.1 - 0.13 12.5 0.4 16 5.7 0.0 2.6 2 0 0 2 2 2 0 AAA domain NPR3 PF03666.13 EXF79296.1 - 0.25 10.1 3.7 0.26 10.0 3.7 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 GYF_2 PF14237.6 EXF79296.1 - 0.38 10.6 1.9 0.56 10.1 0.0 2.2 2 0 0 2 2 2 0 GYF domain 2 U1snRNP70_N PF12220.8 EXF79296.1 - 0.44 11.2 9.4 0.93 10.2 9.4 1.5 1 0 0 1 1 1 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal CDC45 PF02724.14 EXF79296.1 - 1.1 7.5 5.2 1.2 7.3 5.2 1.1 1 0 0 1 1 1 0 CDC45-like protein Amidohydro_2 PF04909.14 EXF79297.1 - 5.8e-17 62.4 0.0 1.5e-09 38.0 0.0 2.1 1 1 1 2 2 2 2 Amidohydrolase Aldo_ket_red PF00248.21 EXF79298.1 - 4e-75 252.7 0.1 4.6e-75 252.5 0.1 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Trypsin PF00089.26 EXF79301.1 - 3.6e-07 30.2 0.0 5.7e-07 29.6 0.0 1.2 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 EXF79301.1 - 0.12 13.3 0.0 0.35 11.7 0.0 1.8 1 1 0 1 1 1 0 Trypsin-like peptidase domain Polysacc_deac_1 PF01522.21 EXF79302.1 - 2.4e-25 88.8 0.0 4.4e-25 88.0 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide deacetylase DUF2334 PF10096.9 EXF79302.1 - 0.083 12.5 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2334) Adeno_PV PF03910.13 EXF79302.1 - 0.85 8.3 7.5 1.2 7.8 7.5 1.2 1 0 0 1 1 1 0 Adenovirus minor core protein PV WYL_3 PF18488.1 EXF79304.1 - 0.033 14.5 0.3 0.094 13.1 0.3 1.7 1 0 0 1 1 1 0 WYL domain Git3 PF11710.8 EXF79305.1 - 7.5e-21 74.8 10.3 1.9e-20 73.5 10.3 1.7 1 1 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 7tm_1 PF00001.21 EXF79305.1 - 2.6e-11 43.3 0.5 3.8e-11 42.8 0.5 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) GPR_Gpa2_C PF11970.8 EXF79305.1 - 0.0028 17.7 0.3 0.009 16.1 0.3 1.8 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 C-term Dicty_CAR PF05462.11 EXF79305.1 - 0.0072 15.5 8.3 0.015 14.4 8.3 1.5 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor ECH_1 PF00378.20 EXF79309.1 - 4.9e-23 81.7 0.0 2.1e-15 56.7 0.0 3.1 3 0 0 3 3 3 3 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EXF79309.1 - 1.1e-13 51.4 0.1 4.6e-10 39.5 0.0 3.0 3 0 0 3 3 3 2 Enoyl-CoA hydratase/isomerase Acetyltransf_10 PF13673.7 EXF79310.1 - 1.8e-07 31.2 0.0 2.8e-07 30.5 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EXF79310.1 - 4.2e-07 30.3 0.0 8.1e-07 29.4 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EXF79310.1 - 2.9e-05 24.3 0.0 3.9e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_9 PF13527.7 EXF79310.1 - 0.0022 18.1 0.0 0.0049 16.9 0.0 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain AAA PF00004.29 EXF79312.1 - 5.7e-16 59.2 0.0 2.4e-15 57.1 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EXF79312.1 - 0.001 19.1 0.1 0.0067 16.4 0.0 2.5 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) LPD28 PF18843.1 EXF79312.1 - 0.0042 16.7 0.0 0.011 15.3 0.0 1.6 1 0 0 1 1 1 1 Large polyvalent protein associated domain 28 AAA_16 PF13191.6 EXF79312.1 - 0.0099 16.3 0.0 0.023 15.1 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EXF79312.1 - 0.012 15.9 0.0 0.029 14.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain Zot PF05707.12 EXF79312.1 - 0.07 12.8 0.0 0.43 10.2 0.0 2.2 3 0 0 3 3 3 0 Zonular occludens toxin (Zot) DUF1233 PF06806.12 EXF79312.1 - 0.091 12.4 0.0 0.25 10.9 0.0 1.7 1 0 0 1 1 1 0 Putative excisionase (DUF1233) CPT PF07931.12 EXF79312.1 - 0.098 12.5 0.0 0.22 11.4 0.0 1.5 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein AAA_18 PF13238.6 EXF79312.1 - 0.14 12.8 0.0 0.41 11.2 0.0 1.8 1 0 0 1 1 1 0 AAA domain Sugar_tr PF00083.24 EXF79313.1 - 3.9e-112 375.4 19.5 6.2e-112 374.7 19.5 1.3 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF79313.1 - 1.5e-25 89.9 32.7 2.5e-19 69.4 12.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Lipase_GDSL_2 PF13472.6 EXF79314.1 - 2.8e-14 53.9 0.1 3.8e-14 53.5 0.1 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EXF79314.1 - 2e-07 31.2 0.0 6.7e-07 29.5 0.0 1.7 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_3 PF14606.6 EXF79314.1 - 0.056 13.6 0.0 0.071 13.2 0.0 1.1 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family PSDC PF12588.8 EXF79314.1 - 0.14 12.2 0.0 0.25 11.3 0.0 1.4 1 1 0 1 1 1 0 Phophatidylserine decarboxylase RTA1 PF04479.13 EXF79315.1 - 1.1e-50 172.1 6.1 1.6e-50 171.6 6.1 1.1 1 0 0 1 1 1 1 RTA1 like protein GST_N_3 PF13417.6 EXF79316.1 - 3.6e-08 33.7 0.0 8e-08 32.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EXF79316.1 - 4.8e-08 33.2 0.0 7.6e-08 32.5 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EXF79316.1 - 1.7e-07 31.2 0.0 3.2e-07 30.3 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EXF79316.1 - 7.7e-06 26.0 0.1 1.2e-05 25.4 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EXF79316.1 - 0.0029 17.8 0.2 0.0064 16.7 0.2 1.6 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 EXF79316.1 - 0.0044 16.8 0.0 0.0098 15.7 0.0 1.6 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_5 PF16865.5 EXF79316.1 - 0.0059 17.2 0.0 0.0087 16.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Epimerase PF01370.21 EXF79317.1 - 1.2e-05 24.9 0.0 1.8e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 EXF79317.1 - 0.021 14.4 0.0 0.03 13.9 0.0 1.2 1 0 0 1 1 1 0 NmrA-like family NAD_binding_4 PF07993.12 EXF79317.1 - 0.036 13.2 0.0 0.053 12.7 0.0 1.3 1 0 0 1 1 1 0 Male sterility protein RmlD_sub_bind PF04321.17 EXF79317.1 - 0.1 11.6 0.1 7 5.6 0.1 2.5 2 1 0 2 2 2 0 RmlD substrate binding domain Peptidase_M35 PF02102.15 EXF79318.1 - 7.4e-81 271.8 20.6 8.9e-81 271.5 20.6 1.0 1 0 0 1 1 1 1 Deuterolysin metalloprotease (M35) family Aspzincin_M35 PF14521.6 EXF79318.1 - 1.3e-37 129.5 9.2 1.3e-37 129.5 9.2 1.5 2 0 0 2 2 2 1 Lysine-specific metallo-endopeptidase Zn_clus PF00172.18 EXF79319.1 - 2.6e-08 33.8 8.9 4.9e-08 33.0 8.9 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EXF79319.1 - 3.9e-08 32.5 1.2 8.9e-08 31.3 0.1 1.9 2 0 0 2 2 2 1 Fungal specific transcription factor domain Peptidase_M28 PF04389.17 EXF79320.1 - 2.4e-33 115.5 0.0 3.5e-33 115.0 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 EXF79320.1 - 6.2e-12 45.4 0.8 1.2e-11 44.4 0.8 1.5 1 0 0 1 1 1 1 PA domain Peptidase_M20 PF01546.28 EXF79320.1 - 0.001 18.8 0.0 0.0029 17.3 0.0 1.8 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 HET PF06985.11 EXF79321.1 - 5.6e-25 88.4 1.3 3.6e-24 85.8 1.3 2.2 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Beta-lactamase PF00144.24 EXF79322.1 - 4e-47 161.1 0.0 5e-47 160.8 0.0 1.1 1 0 0 1 1 1 1 Beta-lactamase Methyltransf_23 PF13489.6 EXF79323.1 - 9.7e-20 71.0 0.0 1.5e-19 70.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF79323.1 - 1.7e-12 47.4 0.0 1.4e-11 44.4 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF79323.1 - 9.9e-11 42.2 0.0 2.3e-10 41.0 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF79323.1 - 1.2e-08 35.4 0.0 6.2e-08 33.2 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF79323.1 - 7.1e-07 29.9 0.0 1.3e-05 25.8 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EXF79323.1 - 0.0012 18.4 0.0 0.0021 17.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_4 PF02390.17 EXF79323.1 - 0.0031 17.0 0.0 0.0072 15.8 0.0 1.5 1 0 0 1 1 1 1 Putative methyltransferase PrmA PF06325.13 EXF79323.1 - 0.0046 16.4 0.0 0.0081 15.6 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) FtsJ PF01728.19 EXF79323.1 - 0.011 15.9 0.0 0.017 15.2 0.0 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_16 PF10294.9 EXF79323.1 - 0.031 14.0 0.0 0.056 13.2 0.0 1.4 1 0 0 1 1 1 0 Lysine methyltransferase MFS_1 PF07690.16 EXF79324.1 - 4.5e-25 88.3 27.5 4.5e-25 88.3 27.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 EXF79324.1 - 0.00015 20.8 2.2 0.00015 20.8 2.2 1.8 2 1 0 2 2 2 1 MFS_1 like family Ac76 PF05814.11 EXF79324.1 - 0.17 11.9 0.3 0.39 10.7 0.3 1.6 1 0 0 1 1 1 0 Orf76 (Ac76) SBP_bac_5 PF00496.22 EXF79325.1 - 4.2e-44 151.0 0.0 6.1e-44 150.5 0.0 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 5 Middle FGE-sulfatase PF03781.16 EXF79326.1 - 3.7e-41 141.4 1.1 4.8e-41 141.0 1.1 1.1 1 0 0 1 1 1 1 Sulfatase-modifying factor enzyme 1 NACHT PF05729.12 EXF79326.1 - 2.4e-05 24.3 0.1 6.2e-05 23.0 0.1 1.7 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 EXF79326.1 - 2.9e-05 24.5 2.6 0.00021 21.7 0.6 2.6 2 1 0 2 2 1 1 AAA ATPase domain AAA_23 PF13476.6 EXF79326.1 - 6.4e-05 23.5 0.0 9.6e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EXF79326.1 - 7.6e-05 23.0 0.3 0.00063 20.0 0.3 2.2 1 1 0 1 1 1 1 AAA domain DUF953 PF06110.11 EXF79326.1 - 7.6e-05 22.3 0.0 0.00018 21.1 0.0 1.6 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF953) AAA_5 PF07728.14 EXF79326.1 - 0.00016 21.7 0.1 0.003 17.6 0.1 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 EXF79326.1 - 0.00031 20.4 0.0 0.00073 19.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain Rad17 PF03215.15 EXF79326.1 - 0.0015 18.5 0.0 0.0024 17.8 0.0 1.2 1 0 0 1 1 1 1 Rad17 P-loop domain Sigma54_activ_2 PF14532.6 EXF79326.1 - 0.0015 18.6 0.0 0.003 17.7 0.0 1.5 1 0 0 1 1 1 1 Sigma-54 interaction domain SMC_N PF02463.19 EXF79326.1 - 0.0076 15.7 0.0 0.012 15.1 0.0 1.2 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EXF79326.1 - 0.0086 15.8 0.0 0.021 14.6 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_19 PF13245.6 EXF79326.1 - 0.011 16.0 0.0 0.29 11.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 EXF79326.1 - 0.013 15.7 0.0 0.027 14.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 EXF79326.1 - 0.015 15.2 0.0 0.051 13.5 0.0 1.7 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea T2SSE PF00437.20 EXF79326.1 - 0.021 13.9 0.0 0.034 13.2 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA PF00004.29 EXF79326.1 - 0.029 14.8 0.0 0.049 14.1 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) PhoH PF02562.16 EXF79326.1 - 0.034 13.6 0.0 0.14 11.6 0.0 1.9 2 0 0 2 2 2 0 PhoH-like protein RNA_helicase PF00910.22 EXF79326.1 - 0.043 14.2 0.0 0.078 13.4 0.0 1.4 1 0 0 1 1 1 0 RNA helicase ABC_tran PF00005.27 EXF79326.1 - 0.049 14.2 0.0 0.096 13.2 0.0 1.4 1 0 0 1 1 1 0 ABC transporter TsaE PF02367.17 EXF79326.1 - 0.051 13.6 0.0 0.28 11.2 0.0 2.0 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_14 PF13173.6 EXF79326.1 - 0.056 13.5 0.0 0.15 12.1 0.0 1.8 1 1 0 1 1 1 0 AAA domain CbiA PF01656.23 EXF79326.1 - 0.097 12.7 0.1 0.25 11.4 0.0 1.7 2 0 0 2 2 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain ATPase PF06745.13 EXF79326.1 - 0.11 11.8 0.0 0.19 11.1 0.0 1.2 1 0 0 1 1 1 0 KaiC IstB_IS21 PF01695.17 EXF79326.1 - 0.11 12.2 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_18 PF13238.6 EXF79326.1 - 0.13 12.8 0.0 0.27 11.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_21 PF13304.6 EXF79326.1 - 0.16 11.8 0.0 0.25 11.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_7 PF12775.7 EXF79326.1 - 0.16 11.5 0.0 0.28 10.7 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region APS_kinase PF01583.20 EXF79326.1 - 0.18 11.7 0.0 0.4 10.6 0.0 1.5 1 0 0 1 1 1 0 Adenylylsulphate kinase cobW PF02492.19 EXF79326.1 - 0.19 11.3 0.0 0.42 10.2 0.0 1.5 2 0 0 2 2 1 0 CobW/HypB/UreG, nucleotide-binding domain NTPase_1 PF03266.15 EXF79326.1 - 0.22 11.4 0.0 0.37 10.7 0.0 1.3 1 0 0 1 1 1 0 NTPase Fungal_trans PF04082.18 EXF79328.1 - 2.9e-05 23.2 0.0 6.5e-05 22.1 0.0 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain DUF1593 PF07632.11 EXF79329.1 - 2e-83 279.8 0.0 2.7e-83 279.4 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1593) REJ PF02010.15 EXF79329.1 - 0.00049 19.0 0.0 0.00076 18.4 0.0 1.2 1 0 0 1 1 1 1 REJ domain NAD_binding_1 PF00175.21 EXF79332.1 - 4.6e-28 98.0 0.0 8.5e-28 97.2 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 EXF79332.1 - 2.5e-14 53.4 0.0 4.3e-14 52.7 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 EXF79332.1 - 1.8e-06 28.2 0.2 0.0024 18.0 0.0 2.6 2 1 1 3 3 3 2 Ferric reductase NAD binding domain VPS9 PF02204.18 EXF79334.1 - 7.8e-18 64.6 0.1 1.6e-17 63.6 0.1 1.5 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain Ank_5 PF13857.6 EXF79334.1 - 9.9e-17 60.8 0.1 5.2e-12 45.8 0.0 4.4 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EXF79334.1 - 1.1e-12 48.4 0.5 0.00025 21.6 0.0 4.3 3 1 0 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EXF79334.1 - 5.4e-09 36.4 0.5 0.19 12.4 0.0 6.0 4 1 0 4 4 4 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EXF79334.1 - 7.8e-07 28.9 0.3 0.31 11.7 0.0 5.2 5 0 0 5 5 5 2 Ankyrin repeat Ank PF00023.30 EXF79334.1 - 0.0008 19.8 0.0 1.5 9.4 0.0 4.3 4 0 0 4 4 4 1 Ankyrin repeat Sugar_tr PF00083.24 EXF79336.1 - 8e-74 249.1 29.2 9.9e-74 248.8 29.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF79336.1 - 8.9e-27 93.9 56.2 1.4e-24 86.7 36.3 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily Mem_trans PF03547.18 EXF79336.1 - 0.0016 16.9 1.4 0.0016 16.9 1.4 3.1 2 1 1 3 3 3 2 Membrane transport protein US6 PF17616.2 EXF79336.1 - 0.1 12.5 0.0 0.21 11.5 0.0 1.5 1 0 0 1 1 1 0 Viral unique short region 6 Fungal_trans_2 PF11951.8 EXF79337.1 - 1.6e-12 47.0 2.0 8.1e-10 38.1 0.2 2.1 2 0 0 2 2 2 2 Fungal specific transcription factor domain EGF_2 PF07974.13 EXF79338.1 - 0.0007 19.9 11.0 0.0013 19.0 11.0 1.5 1 0 0 1 1 1 1 EGF-like domain hEGF PF12661.7 EXF79338.1 - 0.45 11.2 4.0 0.98 10.2 4.0 1.6 1 0 0 1 1 1 0 Human growth factor-like EGF EB PF01683.18 EXF79338.1 - 0.92 9.8 8.8 1.9 8.9 8.8 1.4 1 0 0 1 1 1 0 EB module NPP1 PF05630.11 EXF79339.1 - 7.8e-70 235.0 0.1 8.9e-70 234.8 0.1 1.0 1 0 0 1 1 1 1 Necrosis inducing protein (NPP1) MFS_1 PF07690.16 EXF79340.1 - 1.8e-15 56.7 21.6 2.4e-14 53.0 15.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily UNC-93 PF05978.16 EXF79340.1 - 1.7e-08 34.3 2.0 6e-08 32.6 2.0 1.9 1 0 0 1 1 1 1 Ion channel regulatory protein UNC-93 Hydrophobin_2 PF06766.11 EXF79341.1 - 4.7e-12 45.7 10.0 7.1e-12 45.1 10.0 1.2 1 0 0 1 1 1 1 Fungal hydrophobin DUF5553 PF17707.1 EXF79341.1 - 0.0096 15.4 1.4 0.011 15.2 1.4 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5553) PHF12_MRG_bd PF16737.5 EXF79342.1 - 0.062 13.0 0.2 0.18 11.6 0.2 1.8 1 0 0 1 1 1 0 PHD finger protein 12 MRG binding domain adh_short PF00106.25 EXF79343.1 - 1.1e-27 96.8 0.0 1.5e-27 96.3 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF79343.1 - 1e-21 77.6 0.1 2.3e-21 76.4 0.1 1.5 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF79343.1 - 4.1e-14 52.9 0.1 8.7e-14 51.8 0.1 1.5 1 1 0 1 1 1 1 KR domain PAC2 PF09754.9 EXF79343.1 - 0.0025 17.9 0.1 0.0041 17.2 0.1 1.3 1 0 0 1 1 1 1 PAC2 family Polysacc_synt_2 PF02719.15 EXF79343.1 - 0.09 11.9 0.0 0.1 11.7 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein ThiF PF00899.21 EXF79343.1 - 0.53 9.6 1.7 3 7.1 0.2 2.1 2 0 0 2 2 2 0 ThiF family NEMO PF11577.8 EXF79344.1 - 0.067 13.2 1.0 0.067 13.2 1.0 1.9 2 0 0 2 2 2 0 NF-kappa-B essential modulator NEMO bZIP_1 PF00170.21 EXF79344.1 - 0.59 10.3 6.0 1.3 9.2 6.0 1.5 1 0 0 1 1 1 0 bZIP transcription factor DivIC PF04977.15 EXF79344.1 - 0.73 9.6 3.4 1.5 8.7 1.4 2.2 2 0 0 2 2 2 0 Septum formation initiator UDPGT PF00201.18 EXF79346.1 - 1.2e-13 50.8 0.0 1.9e-11 43.4 0.0 2.1 2 0 0 2 2 2 2 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_transf_28 PF03033.20 EXF79346.1 - 0.13 12.4 0.0 0.39 10.7 0.0 1.8 2 0 0 2 2 2 0 Glycosyltransferase family 28 N-terminal domain AcetylCoA_hydro PF02550.15 EXF79347.1 - 1.2e-49 169.0 0.0 1.9e-49 168.4 0.0 1.3 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase N-terminal domain AcetylCoA_hyd_C PF13336.6 EXF79347.1 - 2.5e-43 147.7 0.0 3.6e-43 147.2 0.0 1.2 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase C-terminal domain Bac_luciferase PF00296.20 EXF79348.1 - 2.3e-57 194.8 1.3 3.1e-57 194.4 1.3 1.1 1 0 0 1 1 1 1 Luciferase-like monooxygenase MFS_1 PF07690.16 EXF79349.1 - 1.4e-08 34.1 34.0 1.4e-08 34.1 34.0 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily UNC-93 PF05978.16 EXF79349.1 - 3.4e-06 26.9 3.6 3.4e-06 26.9 3.6 3.0 3 0 0 3 3 3 2 Ion channel regulatory protein UNC-93 FMO-like PF00743.19 EXF79350.1 - 4.4e-12 45.2 0.0 1.7e-10 40.0 0.0 2.4 2 1 0 2 2 2 1 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.6 EXF79350.1 - 1.9e-10 40.8 0.0 8.1e-10 38.8 0.0 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 EXF79350.1 - 8.2e-08 31.9 0.2 1.3e-06 27.9 0.0 2.6 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EXF79350.1 - 2.4e-07 30.3 0.0 1.4e-05 24.5 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EXF79350.1 - 3.4e-05 23.1 0.1 0.0015 17.7 0.0 2.7 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Thi4 PF01946.17 EXF79350.1 - 0.0013 18.0 0.0 0.007 15.6 0.0 2.0 2 0 0 2 2 2 1 Thi4 family NAD_binding_9 PF13454.6 EXF79350.1 - 0.0013 18.7 0.3 0.7 9.9 0.0 3.5 3 1 0 3 3 3 1 FAD-NAD(P)-binding DAO PF01266.24 EXF79350.1 - 0.022 14.3 0.4 4.8 6.7 0.0 2.7 2 1 0 2 2 2 0 FAD dependent oxidoreductase OmdA PF13376.6 EXF79350.1 - 0.11 12.5 0.8 5.1 7.2 0.1 3.0 3 0 0 3 3 3 0 Bacteriocin-protection, YdeI or OmpD-Associated MFS_1 PF07690.16 EXF79351.1 - 4.1e-28 98.3 29.7 6e-28 97.8 29.7 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Bac_luciferase PF00296.20 EXF79352.1 - 8.2e-59 199.6 0.1 1.1e-58 199.2 0.1 1.1 1 0 0 1 1 1 1 Luciferase-like monooxygenase Glyco_hydro_12 PF01670.16 EXF79353.1 - 3e-45 154.8 10.2 3.5e-45 154.6 10.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 12 Phage_holin_5_1 PF06946.11 EXF79353.1 - 1.3 9.5 8.3 0.3 11.5 1.4 2.6 1 1 1 2 2 2 0 Bacteriophage A118-like holin, Hol118 Fungal_trans PF04082.18 EXF79354.1 - 3.1e-12 46.1 0.9 4.2e-12 45.7 0.9 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF79354.1 - 1.2e-08 34.9 10.9 2.9e-08 33.7 10.9 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FAD_binding_3 PF01494.19 EXF79355.1 - 3.3e-17 62.7 0.1 6.7e-17 61.8 0.1 1.5 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.24 EXF79355.1 - 0.00039 20.1 0.6 0.0039 16.8 0.1 2.1 1 1 1 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EXF79355.1 - 0.00081 19.6 0.1 0.0018 18.5 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 EXF79355.1 - 0.0018 17.6 0.0 0.0027 17.0 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EXF79355.1 - 0.0056 15.9 0.0 0.0091 15.3 0.0 1.3 1 0 0 1 1 1 1 Thi4 family TrkA_N PF02254.18 EXF79355.1 - 0.014 15.6 0.0 0.034 14.4 0.0 1.6 1 0 0 1 1 1 0 TrkA-N domain Pyr_redox_2 PF07992.14 EXF79355.1 - 0.054 12.7 0.0 0.12 11.5 0.0 1.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.16 EXF79355.1 - 0.18 11.5 0.0 0.33 10.6 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Glyco_hydro_61 PF03443.14 EXF79358.1 - 5.8e-07 29.6 0.0 1e-06 28.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 BTB PF00651.31 EXF79361.1 - 7.7e-05 22.9 0.0 0.00015 21.9 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain ADH_N PF08240.12 EXF79362.1 - 0.2 11.5 0.0 0.42 10.5 0.0 1.5 1 0 0 1 1 1 0 Alcohol dehydrogenase GroES-like domain F-box PF00646.33 EXF79363.1 - 0.015 15.1 3.2 0.11 12.4 3.2 2.5 1 1 0 1 1 1 0 F-box domain UCH PF00443.29 EXF79364.1 - 7.2e-39 133.8 0.4 2.1e-34 119.2 0.0 2.2 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EXF79364.1 - 5.4e-08 32.8 6.0 1.6e-06 28.0 6.0 2.8 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DUF4071 PF13281.6 EXF79364.1 - 0.18 10.8 0.0 0.32 10.0 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4071) Oxysterol_BP PF01237.18 EXF79365.1 - 8.1e-64 215.8 1.0 2.8e-61 207.4 1.0 2.0 1 1 0 1 1 1 1 Oxysterol-binding protein Fringe PF02434.16 EXF79366.1 - 2e-08 34.0 0.4 3.4e-07 30.0 0.4 2.0 1 1 0 1 1 1 1 Fringe-like PAN_1 PF00024.26 EXF79366.1 - 0.003 17.5 0.0 0.0054 16.7 0.0 1.3 1 0 0 1 1 1 1 PAN domain Galactosyl_T PF01762.21 EXF79366.1 - 0.063 13.1 0.1 0.21 11.4 0.1 1.8 1 1 1 2 2 2 0 Galactosyltransferase DUF604 PF04646.12 EXF79366.1 - 0.1 12.0 0.0 0.16 11.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF604 BCS1_N PF08740.11 EXF79368.1 - 4.3e-43 147.5 0.0 6e-43 147.0 0.0 1.2 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 EXF79368.1 - 1.9e-16 60.7 0.0 3.2e-16 60.0 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 EXF79368.1 - 0.0003 20.4 0.0 0.028 14.0 0.0 2.5 1 1 1 2 2 2 1 AAA domain AAA_7 PF12775.7 EXF79368.1 - 0.00093 18.8 0.0 0.0017 17.9 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_5 PF07728.14 EXF79368.1 - 0.0013 18.7 0.0 0.0028 17.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EXF79368.1 - 0.0031 17.9 0.0 0.0069 16.8 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain RuvB_N PF05496.12 EXF79368.1 - 0.0043 16.8 0.0 0.013 15.3 0.0 1.7 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EXF79368.1 - 0.015 15.6 0.0 0.029 14.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.13 EXF79368.1 - 0.02 14.1 0.0 0.041 13.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_33 PF13671.6 EXF79368.1 - 0.023 14.8 0.0 0.054 13.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EXF79368.1 - 0.032 14.7 0.0 0.057 13.9 0.0 1.4 1 0 0 1 1 1 0 ABC transporter AAA_29 PF13555.6 EXF79368.1 - 0.032 14.0 0.0 0.073 12.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_18 PF13238.6 EXF79368.1 - 0.037 14.6 0.0 0.071 13.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain PPV_E1_C PF00519.17 EXF79368.1 - 0.062 12.1 0.0 0.094 11.5 0.0 1.2 1 0 0 1 1 1 0 Papillomavirus helicase AAA_17 PF13207.6 EXF79368.1 - 0.079 13.4 0.1 0.52 10.7 0.0 2.1 1 1 1 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 EXF79368.1 - 0.085 12.9 0.0 0.2 11.7 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase RNA_helicase PF00910.22 EXF79368.1 - 0.11 12.9 0.0 0.22 12.0 0.0 1.6 1 0 0 1 1 1 0 RNA helicase ATP_bind_1 PF03029.17 EXF79368.1 - 0.13 12.0 0.0 0.2 11.4 0.0 1.2 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein RsgA_GTPase PF03193.16 EXF79368.1 - 0.13 12.2 0.0 0.28 11.1 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase AFOR_C PF01314.18 EXF79368.1 - 0.13 11.2 0.0 0.2 10.6 0.0 1.2 1 0 0 1 1 1 0 Aldehyde ferredoxin oxidoreductase, domains 2 & 3 DUF2263 PF10021.9 EXF79369.1 - 3.2e-22 79.5 0.0 6.7e-22 78.4 0.0 1.5 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2263) Zn_clus PF00172.18 EXF79371.1 - 6.7e-08 32.5 9.1 1.2e-07 31.7 9.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EXF79371.1 - 1.2e-06 27.8 0.9 2.1e-06 27.0 0.9 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Sugar_tr PF00083.24 EXF79372.1 - 3.4e-80 270.1 15.0 3.4e-80 270.1 15.0 1.4 1 1 1 2 2 2 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF79372.1 - 8.6e-18 64.4 31.5 2e-17 63.2 27.8 2.6 1 1 2 3 3 3 2 Major Facilitator Superfamily Alpha-amylase PF00128.24 EXF79373.1 - 1e-110 370.5 0.1 1.9e-110 369.6 0.1 1.3 1 0 0 1 1 1 1 Alpha amylase, catalytic domain Malt_amylase_C PF16657.5 EXF79373.1 - 0.0037 17.4 0.0 0.022 14.9 0.0 2.2 2 0 0 2 2 2 1 Maltogenic Amylase, C-terminal domain hDGE_amylase PF14701.6 EXF79373.1 - 0.0039 16.3 0.0 0.0094 15.1 0.0 1.5 2 0 0 2 2 2 1 Glycogen debranching enzyme, glucanotransferase domain DUF3459 PF11941.8 EXF79373.1 - 0.0053 17.1 0.0 0.014 15.7 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF3459) Glyco_hydro_42C PF08533.10 EXF79373.1 - 0.023 14.4 0.0 0.07 12.9 0.0 1.8 2 0 0 2 2 2 0 Beta-galactosidase C-terminal domain Peroxidase_2 PF01328.17 EXF79374.1 - 2.3e-41 142.4 0.0 3e-41 142.0 0.0 1.1 1 0 0 1 1 1 1 Peroxidase, family 2 DUF2148 PF09918.9 EXF79375.1 - 6.6 6.9 6.6 5.2 7.2 1.8 3.0 2 1 1 3 3 3 0 Uncharacterized protein containing a ferredoxin domain (DUF2148) FAD_binding_4 PF01565.23 EXF79376.1 - 4.6e-17 62.1 1.5 8.5e-17 61.2 1.5 1.5 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EXF79376.1 - 1.5e-10 41.0 2.2 3.5e-10 39.8 2.2 1.7 1 0 0 1 1 1 1 Berberine and berberine like Cytokin-bind PF09265.10 EXF79376.1 - 0.025 14.0 0.2 0.037 13.4 0.2 1.2 1 0 0 1 1 1 0 Cytokinin dehydrogenase 1, FAD and cytokinin binding MFS_1 PF07690.16 EXF79377.1 - 8.2e-19 67.7 51.9 3.3e-09 36.1 18.8 2.7 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EXF79377.1 - 5e-12 45.0 15.3 8e-12 44.4 15.3 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) PUCC PF03209.15 EXF79377.1 - 0.004 16.2 8.9 0.004 16.2 8.9 3.9 3 1 1 4 4 4 2 PUCC protein Pox_A14 PF05767.12 EXF79377.1 - 0.037 14.2 0.8 0.037 14.2 0.8 3.6 4 1 0 4 4 4 0 Poxvirus virion envelope protein A14 NmrA PF05368.13 EXF79378.1 - 1.4e-22 80.4 0.0 1.9e-22 80.0 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EXF79378.1 - 1.5e-12 47.8 0.0 4.1e-12 46.4 0.0 1.7 1 1 0 1 1 1 1 NAD(P)H-binding Semialdhyde_dh PF01118.24 EXF79378.1 - 0.15 12.5 0.0 0.4 11.1 0.0 1.8 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain Maf_N PF08383.11 EXF79380.1 - 0.024 14.4 0.1 0.046 13.5 0.1 1.4 1 0 0 1 1 1 0 Maf N-terminal region CIA30 PF08547.12 EXF79381.1 - 7.3e-38 130.1 0.0 9e-38 129.8 0.0 1.0 1 0 0 1 1 1 1 Complex I intermediate-associated protein 30 (CIA30) Ribosomal_L18_c PF14204.6 EXF79383.1 - 1.8 9.6 7.8 3 8.8 0.0 3.0 3 0 0 3 3 3 0 Ribosomal L18 C-terminal region Epimerase PF01370.21 EXF79384.1 - 1.1e-07 31.6 0.5 0.00015 21.3 0.1 2.2 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EXF79384.1 - 3.9e-05 23.6 0.0 7e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding KR PF08659.10 EXF79384.1 - 0.00016 21.6 0.1 0.00038 20.4 0.1 1.6 1 1 0 1 1 1 1 KR domain GDP_Man_Dehyd PF16363.5 EXF79384.1 - 0.0055 16.1 0.0 1.3 8.3 0.0 2.1 2 0 0 2 2 2 2 GDP-mannose 4,6 dehydratase Sacchrp_dh_NADP PF03435.18 EXF79384.1 - 0.11 12.8 0.1 0.21 11.9 0.1 1.5 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain TrkA_N PF02254.18 EXF79384.1 - 0.15 12.3 0.3 0.34 11.2 0.1 1.7 2 1 0 2 2 2 0 TrkA-N domain CorA PF01544.18 EXF79385.1 - 0.00094 18.6 0.2 0.0013 18.1 0.2 1.2 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein DUF2207 PF09972.9 EXF79385.1 - 0.14 10.9 0.1 0.17 10.6 0.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) GMC_oxred_N PF00732.19 EXF79386.1 - 1.6e-31 109.8 0.3 1.4e-30 106.7 0.7 2.2 2 1 0 2 2 2 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EXF79386.1 - 8.6e-29 100.9 0.0 1.5e-28 100.2 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.24 EXF79386.1 - 0.001 18.2 0.0 0.015 14.4 0.0 2.0 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.14 EXF79386.1 - 0.0028 16.9 0.0 0.023 14.0 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EXF79386.1 - 0.0067 15.7 0.0 0.94 8.7 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EXF79386.1 - 0.13 12.5 0.1 0.32 11.3 0.1 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain RRM_1 PF00076.22 EXF79387.1 - 2.4e-08 33.7 0.1 4.3e-08 32.9 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EXF79387.1 - 9.5e-05 22.3 0.0 0.00017 21.5 0.0 1.4 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 EXF79387.1 - 0.0051 16.7 0.1 0.0088 15.9 0.1 1.3 1 0 0 1 1 1 1 Occluded RNA-recognition motif RRM_3 PF08777.11 EXF79387.1 - 0.083 12.9 0.1 0.16 12.0 0.1 1.4 1 0 0 1 1 1 0 RNA binding motif DUF3659 PF12396.8 EXF79389.1 - 3.1e-165 536.3 98.9 1.6e-21 76.0 2.3 10.4 10 0 0 10 10 10 9 Protein of unknown function (DUF3659) GCV_T_C PF08669.11 EXF79389.1 - 0.002 18.0 12.1 5.6 7.0 0.0 7.3 6 1 3 9 9 9 2 Glycine cleavage T-protein C-terminal barrel domain DUF1917 PF08939.10 EXF79389.1 - 0.0058 16.6 1.5 0.015 15.2 1.5 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1917) Packaging_FI PF14000.6 EXF79389.1 - 1.8 9.0 14.0 0.085 13.3 6.2 2.8 1 1 1 2 2 2 0 DNA packaging protein FI DUF3659 PF12396.8 EXF79390.1 - 1.5e-17 63.2 5.5 5.5e-13 48.6 0.9 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF3659) DUF719 PF05334.13 EXF79392.1 - 0.0042 17.3 0.8 0.005 17.1 0.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF719) LPD3 PF18798.1 EXF79393.1 - 0.097 12.9 0.0 0.15 12.3 0.0 1.2 1 0 0 1 1 1 0 Large polyvalent protein-associated domain 3 DUF2046 PF09755.9 EXF79395.1 - 0.0025 17.1 1.4 0.041 13.1 0.1 2.2 2 0 0 2 2 2 1 Uncharacterized conserved protein H4 (DUF2046) CASP_C PF08172.12 EXF79395.1 - 0.017 14.5 6.7 0.92 8.8 0.1 2.3 2 0 0 2 2 2 0 CASP C terminal DivIC PF04977.15 EXF79395.1 - 0.02 14.6 0.7 0.02 14.6 0.7 1.7 2 0 0 2 2 2 0 Septum formation initiator NUDE_C PF04880.13 EXF79395.1 - 0.04 14.4 0.4 0.04 14.4 0.4 3.5 3 1 0 3 3 3 0 NUDE protein, C-terminal conserved region DUF3138 PF11336.8 EXF79395.1 - 2.3 6.8 12.2 0.16 10.6 2.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3138) Angiomotin_C PF12240.8 EXF79395.1 - 9.4 5.7 11.4 2.4 7.7 0.4 2.8 3 0 0 3 3 3 0 Angiomotin C terminal Phage_TAC_6 PF09550.10 EXF79396.1 - 0.12 12.8 2.8 0.27 11.7 2.8 1.5 1 0 0 1 1 1 0 Phage tail assembly chaperone protein, TAC FMO-like PF00743.19 EXF79397.1 - 1.4e-18 66.6 1.6 6.9e-17 61.1 0.1 2.4 2 1 0 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 EXF79397.1 - 6.9e-17 61.6 0.0 1.3e-11 44.3 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EXF79397.1 - 9.5e-11 41.5 0.0 1.3e-09 37.8 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EXF79397.1 - 5.5e-09 35.6 0.1 2.7e-08 33.4 0.0 1.9 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 EXF79397.1 - 9.1e-07 29.0 1.0 9.9e-06 25.7 0.2 2.8 2 1 0 2 2 2 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 EXF79397.1 - 0.0026 17.8 1.0 7.2 6.6 0.0 3.7 3 1 0 3 3 3 2 FAD-NAD(P)-binding DAO PF01266.24 EXF79397.1 - 0.016 14.8 0.1 2.9 7.4 0.0 2.6 2 0 0 2 2 2 0 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EXF79397.1 - 0.022 13.9 0.0 0.041 13.0 0.0 1.5 1 0 0 1 1 1 0 FAD binding domain Thi4 PF01946.17 EXF79397.1 - 0.072 12.3 0.4 0.16 11.2 0.0 1.7 2 0 0 2 2 2 0 Thi4 family CCP_MauG PF03150.14 EXF79397.1 - 0.16 12.6 0.0 0.32 11.6 0.0 1.5 1 0 0 1 1 1 0 Di-haem cytochrome c peroxidase Lycopene_cycl PF05834.12 EXF79397.1 - 0.17 10.9 0.1 0.98 8.4 0.1 2.2 2 1 0 2 2 2 0 Lycopene cyclase protein Pyr_redox PF00070.27 EXF79397.1 - 0.97 10.0 2.9 9.9 6.8 0.8 2.7 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Beta-lactamase PF00144.24 EXF79398.1 - 1.2e-41 143.0 0.0 5.1e-41 141.0 0.0 1.7 1 1 0 1 1 1 1 Beta-lactamase Zn_clus PF00172.18 EXF79399.1 - 0.038 14.1 8.2 0.14 12.3 8.2 2.0 1 1 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain FmdA_AmdA PF03069.15 EXF79400.1 - 1.4e-54 185.4 0.0 7.4e-35 120.5 0.0 2.1 1 1 1 2 2 2 2 Acetamidase/Formamidase family DUF3433 PF11915.8 EXF79401.1 - 2.1e-21 76.1 14.5 7.2e-19 68.0 4.7 3.8 5 0 0 5 5 5 2 Protein of unknown function (DUF3433) SnoaL_2 PF12680.7 EXF79402.1 - 5e-12 46.4 0.2 7.8e-12 45.7 0.2 1.3 1 0 0 1 1 1 1 SnoaL-like domain SnoaL PF07366.12 EXF79402.1 - 7e-07 29.1 0.3 2e-06 27.6 0.3 1.7 1 1 0 1 1 1 1 SnoaL-like polyketide cyclase DUF4440 PF14534.6 EXF79402.1 - 0.00037 20.9 0.1 0.00066 20.1 0.1 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF4440) SnoaL_3 PF13474.6 EXF79402.1 - 0.0036 17.6 0.3 0.0068 16.7 0.3 1.8 1 1 0 1 1 1 1 SnoaL-like domain Glyco_hydro_79C PF16862.5 EXF79403.1 - 2e-17 64.0 1.5 4.8e-17 62.7 1.5 1.7 1 0 0 1 1 1 1 Glycosyl hydrolase family 79 C-terminal beta domain DUF1769 PF08588.10 EXF79404.1 - 5.3e-27 93.8 0.5 1.2e-26 92.6 0.2 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF1769) Sugar_tr PF00083.24 EXF79405.1 - 1.2e-29 103.5 8.3 1.5e-29 103.1 8.3 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF79405.1 - 2.8e-14 52.8 14.0 3.8e-14 52.4 14.0 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily HAD PF12710.7 EXF79406.1 - 7.8e-24 85.1 0.0 1e-23 84.8 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EXF79406.1 - 0.0045 17.3 0.3 0.16 12.2 0.0 2.7 1 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase UMPH-1 PF05822.12 EXF79406.1 - 0.0045 16.5 0.0 0.0082 15.7 0.0 1.6 1 1 0 1 1 1 1 Pyrimidine 5'-nucleotidase (UMPH-1) Put_Phosphatase PF06888.12 EXF79406.1 - 0.09 12.2 0.0 3.6 6.9 0.0 2.1 2 0 0 2 2 2 0 Putative Phosphatase MFS_1 PF07690.16 EXF79407.1 - 2.3e-24 86.0 75.3 9.5e-20 70.8 45.5 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily LapA_dom PF06305.11 EXF79407.1 - 0.95 9.3 4.9 5.6 6.9 1.1 3.2 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain MFS_3 PF05977.13 EXF79407.1 - 1.6 7.0 18.5 0.54 8.6 1.7 2.5 1 1 0 2 2 2 0 Transmembrane secretion effector eIF-1a PF01176.19 EXF79408.1 - 3.5e-20 71.6 0.2 4.8e-20 71.1 0.2 1.2 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 Terminase_6 PF03237.15 EXF79408.1 - 0.04 13.6 0.0 0.046 13.4 0.0 1.1 1 0 0 1 1 1 0 Terminase-like family ALG3 PF05208.13 EXF79409.1 - 1.3e-144 482.0 15.6 1.6e-144 481.8 15.6 1.1 1 0 0 1 1 1 1 ALG3 protein DAO PF01266.24 EXF79410.1 - 8.6e-35 120.9 0.9 9.9e-35 120.7 0.9 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EXF79410.1 - 0.00032 20.8 0.1 0.00067 19.8 0.1 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 EXF79410.1 - 0.0035 16.6 0.1 0.0035 16.6 0.1 1.6 2 0 0 2 2 2 1 Thi4 family FAD_binding_2 PF00890.24 EXF79410.1 - 0.0044 16.2 0.0 0.007 15.5 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EXF79410.1 - 0.018 14.3 0.0 0.031 13.5 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EXF79410.1 - 0.041 14.5 0.1 0.1 13.2 0.1 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EXF79410.1 - 0.21 10.4 0.1 0.37 9.6 0.1 1.4 2 0 0 2 2 2 0 Tryptophan halogenase HI0933_like PF03486.14 EXF79410.1 - 0.23 10.1 0.1 0.34 9.5 0.1 1.2 1 0 0 1 1 1 0 HI0933-like protein Thioredoxin PF00085.20 EXF79411.1 - 3.8e-24 84.7 0.3 7.5e-24 83.7 0.3 1.4 1 0 0 1 1 1 1 Thioredoxin Ank_2 PF12796.7 EXF79411.1 - 2.7e-10 40.7 0.8 0.047 14.3 0.0 5.7 4 1 2 6 6 5 3 Ankyrin repeats (3 copies) Patatin PF01734.22 EXF79411.1 - 3.8e-08 33.8 0.0 9.1e-08 32.5 0.0 1.6 1 0 0 1 1 1 1 Patatin-like phospholipase NACHT PF05729.12 EXF79411.1 - 1.7e-06 28.1 1.1 2.4e-05 24.3 0.0 3.1 2 1 1 3 3 3 1 NACHT domain AAA_16 PF13191.6 EXF79411.1 - 7e-05 23.3 0.1 0.00044 20.7 0.1 2.4 1 0 0 1 1 1 1 AAA ATPase domain Thioredoxin_8 PF13905.6 EXF79411.1 - 0.00016 21.9 0.0 0.00055 20.2 0.0 1.9 1 0 0 1 1 1 1 Thioredoxin-like OST3_OST6 PF04756.13 EXF79411.1 - 0.0002 20.8 0.0 0.00036 20.0 0.0 1.3 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Ank_4 PF13637.6 EXF79411.1 - 0.00052 20.5 0.1 3.4 8.4 0.0 4.3 4 0 0 4 4 4 1 Ankyrin repeats (many copies) KAP_NTPase PF07693.14 EXF79411.1 - 0.0044 16.3 0.5 0.64 9.2 0.2 2.4 1 1 1 2 2 2 1 KAP family P-loop domain Thioredoxin_7 PF13899.6 EXF79411.1 - 0.0051 17.0 0.1 0.018 15.2 0.1 2.0 1 0 0 1 1 1 1 Thioredoxin-like AhpC-TSA PF00578.21 EXF79411.1 - 0.011 15.6 0.0 0.029 14.3 0.0 1.6 1 0 0 1 1 1 0 AhpC/TSA family Ank_3 PF13606.6 EXF79411.1 - 0.013 16.0 0.2 0.32 11.7 0.0 3.5 3 0 0 3 3 3 0 Ankyrin repeat Thioredoxin_2 PF13098.6 EXF79411.1 - 0.016 15.6 0.0 0.043 14.3 0.0 1.7 1 0 0 1 1 1 0 Thioredoxin-like domain Ank_5 PF13857.6 EXF79411.1 - 0.06 13.7 1.3 12 6.3 0.0 3.3 3 0 0 3 3 3 0 Ankyrin repeats (many copies) AAA_22 PF13401.6 EXF79411.1 - 0.061 13.6 0.1 0.5 10.6 0.0 2.6 2 1 1 3 3 3 0 AAA domain Redoxin PF08534.10 EXF79411.1 - 0.084 12.6 0.1 0.25 11.1 0.1 1.7 1 0 0 1 1 1 0 Redoxin Glutaredoxin PF00462.24 EXF79411.1 - 0.087 13.1 0.1 0.31 11.3 0.1 2.0 1 0 0 1 1 1 0 Glutaredoxin Ank PF00023.30 EXF79411.1 - 0.088 13.3 1.0 0.8 10.3 0.0 3.2 3 0 0 3 3 3 0 Ankyrin repeat Fungal_trans_2 PF11951.8 EXF79412.1 - 8.2e-43 146.7 0.0 1e-42 146.3 0.0 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF79412.1 - 5e-05 23.3 15.7 0.0001 22.3 15.7 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain VirJ PF06057.11 EXF79413.1 - 0.19 11.6 0.0 0.32 10.8 0.0 1.2 1 0 0 1 1 1 0 Bacterial virulence protein (VirJ) Glyco_hydro_43 PF04616.14 EXF79414.1 - 1.3e-48 165.8 0.7 1.8e-48 165.3 0.7 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 CBM_6 PF03422.15 EXF79414.1 - 4.9e-37 127.0 1.1 4.9e-37 127.0 1.1 2.0 2 0 0 2 2 2 1 Carbohydrate binding module (family 6) DUF5010_C PF18099.1 EXF79414.1 - 2.6e-07 30.8 0.2 4.5e-07 30.0 0.2 1.4 1 0 0 1 1 1 1 DUF5010 C-terminal domain Glyco_hydro_32N PF00251.20 EXF79414.1 - 0.0053 16.4 2.1 0.015 14.9 2.1 1.6 1 1 0 1 1 1 1 Glycosyl hydrolases family 32 N-terminal domain Big_3_5 PF16640.5 EXF79414.1 - 0.0094 16.1 1.5 0.023 14.9 1.5 1.6 1 0 0 1 1 1 1 Bacterial Ig-like domain (group 3) HET PF06985.11 EXF79415.1 - 1.3e-30 106.7 0.8 2.2e-30 105.9 0.8 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) OPT PF03169.15 EXF79416.1 - 4.8e-24 85.0 5.6 5.5e-24 84.8 5.6 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein OPT PF03169.15 EXF79417.1 - 4e-86 290.0 32.7 4.8e-86 289.7 32.7 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Dioxygenase_C PF00775.21 EXF79418.1 - 0.00015 21.2 0.1 0.00046 19.7 0.1 1.8 1 1 0 1 1 1 1 Dioxygenase DUF1929 PF09118.11 EXF79419.1 - 6.1e-26 90.6 0.2 3.6e-25 88.1 0.0 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF1929) WSC PF01822.19 EXF79419.1 - 1.5e-23 82.7 26.3 4e-13 49.3 11.5 2.7 2 0 0 2 2 2 2 WSC domain Kelch_6 PF13964.6 EXF79419.1 - 1.1e-11 44.5 4.4 0.00012 22.2 0.0 4.8 5 0 0 5 5 5 3 Kelch motif Kelch_2 PF07646.15 EXF79419.1 - 1.9e-08 33.9 1.1 0.2 11.7 0.1 4.8 4 0 0 4 4 4 3 Kelch motif Glyoxal_oxid_N PF07250.11 EXF79419.1 - 1.5e-06 27.6 0.1 0.02 14.1 0.1 2.4 2 0 0 2 2 2 2 Glyoxal oxidase N-terminus Kelch_1 PF01344.25 EXF79419.1 - 2.8e-06 26.8 10.9 0.00029 20.3 0.1 4.5 4 2 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 EXF79419.1 - 1.4e-05 25.0 9.1 0.12 12.4 0.1 5.1 4 1 0 4 4 4 2 Galactose oxidase, central domain Mg_trans_NIPA PF05653.14 EXF79420.1 - 2.5e-90 302.6 22.9 3.4e-90 302.2 22.9 1.1 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 EXF79420.1 - 1.4e-05 25.3 7.0 1.4e-05 25.3 7.0 3.1 3 0 0 3 3 3 1 EamA-like transporter family TMEM40 PF15817.5 EXF79420.1 - 1.2 8.9 2.6 15 5.4 0.5 2.7 2 0 0 2 2 2 0 Transmembrane protein 40 family SLC35F PF06027.12 EXF79420.1 - 2.7 7.4 15.5 0.028 13.9 5.5 2.1 1 1 0 2 2 2 0 Solute carrier family 35 adh_short_C2 PF13561.6 EXF79422.1 - 4.4e-23 82.1 9.8 1.1e-15 57.8 2.5 2.1 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF79422.1 - 4.5e-17 62.1 3.8 7.9e-11 41.8 0.2 2.2 2 0 0 2 2 2 2 short chain dehydrogenase KR PF08659.10 EXF79422.1 - 8.6e-07 29.0 2.7 1.1e-06 28.7 1.3 1.9 1 1 1 2 2 2 1 KR domain Sacchrp_dh_NADP PF03435.18 EXF79422.1 - 4.5e-05 23.7 1.2 0.00011 22.5 0.1 2.0 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain DAO PF01266.24 EXF79422.1 - 0.0022 17.7 5.5 0.33 10.5 4.4 2.2 1 1 1 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EXF79422.1 - 0.0095 15.2 2.5 0.014 14.6 1.6 1.6 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.16 EXF79422.1 - 0.013 15.1 0.2 0.023 14.4 0.2 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA F420_oxidored PF03807.17 EXF79422.1 - 0.027 15.0 1.0 0.027 15.0 1.0 2.8 2 2 1 3 3 3 0 NADP oxidoreductase coenzyme F420-dependent 3Beta_HSD PF01073.19 EXF79422.1 - 0.037 13.0 0.0 0.05 12.6 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family 2-Hacid_dh_C PF02826.19 EXF79423.1 - 6.4e-39 133.1 0.0 1.2e-38 132.3 0.0 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EXF79423.1 - 2.5e-10 40.1 0.0 3.5e-10 39.7 0.0 1.3 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain F420_oxidored PF03807.17 EXF79423.1 - 0.0045 17.6 0.1 0.0086 16.6 0.1 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 EXF79423.1 - 0.0045 17.2 0.1 0.0094 16.1 0.1 1.5 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase UDPG_MGDP_dh_C PF03720.15 EXF79423.1 - 0.0092 16.4 0.1 1.1 9.7 0.1 2.5 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain Sacchrp_dh_NADP PF03435.18 EXF79423.1 - 0.017 15.4 0.1 0.11 12.8 0.1 2.1 1 1 1 2 2 2 0 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 EXF79423.1 - 0.02 14.9 0.0 0.037 14.1 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Gp_dh_N PF00044.24 EXF79423.1 - 0.025 14.9 0.0 0.066 13.6 0.0 1.7 1 0 0 1 1 1 0 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain DapB_N PF01113.20 EXF79423.1 - 0.042 14.0 0.0 0.083 13.0 0.0 1.5 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus GMC_oxred_N PF00732.19 EXF79424.1 - 9.9e-54 182.7 0.5 1.1e-51 176.0 0.5 2.2 1 1 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EXF79424.1 - 1.2e-36 126.4 0.0 2.6e-36 125.3 0.0 1.6 1 0 0 1 1 1 1 GMC oxidoreductase Pyr_redox_3 PF13738.6 EXF79424.1 - 4.3e-06 26.2 0.5 0.08 12.2 0.0 2.6 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EXF79424.1 - 1e-05 24.8 1.8 0.027 13.6 0.6 2.5 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.24 EXF79424.1 - 1.2e-05 25.1 2.9 0.00087 19.0 0.5 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase Thi4 PF01946.17 EXF79424.1 - 5.7e-05 22.5 0.0 0.00012 21.5 0.0 1.4 1 0 0 1 1 1 1 Thi4 family NAD_binding_8 PF13450.6 EXF79424.1 - 0.00017 21.8 1.2 0.00026 21.2 0.3 1.8 2 0 0 2 2 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EXF79424.1 - 0.00091 18.5 1.9 0.29 10.3 0.5 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EXF79424.1 - 0.0013 17.9 0.2 0.0022 17.1 0.2 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein HI0933_like PF03486.14 EXF79424.1 - 0.0044 15.8 1.2 0.088 11.5 0.1 2.2 2 0 0 2 2 2 1 HI0933-like protein K_oxygenase PF13434.6 EXF79424.1 - 0.094 11.8 0.2 5.4 6.1 0.0 2.1 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox PF00070.27 EXF79424.1 - 0.099 13.2 0.4 6.6 7.4 0.1 2.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EXF79424.1 - 0.19 11.7 1.6 0.28 11.2 0.1 1.9 2 0 0 2 2 2 0 FAD-NAD(P)-binding tRNA-synt_2 PF00152.20 EXF79425.1 - 1.9e-79 267.0 0.0 2.4e-79 266.7 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EXF79425.1 - 4.4e-05 23.4 0.0 6.8e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA_anti_2 PF13742.6 EXF79425.1 - 0.12 12.6 0.0 0.22 11.7 0.0 1.4 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain DUF2263 PF10021.9 EXF79426.1 - 1.4e-10 41.7 0.0 2.5e-10 40.9 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2263) BORCS6 PF10157.9 EXF79426.1 - 1.4 9.2 4.0 2.1 8.6 4.0 1.2 1 0 0 1 1 1 0 BLOC-1-related complex sub-unit 6 CCDC24 PF15669.5 EXF79426.1 - 1.7 8.4 3.3 3.2 7.6 3.3 1.4 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 24 family RSRP PF17069.5 EXF79426.1 - 2.7 7.5 17.4 4.5 6.8 17.4 1.3 1 0 0 1 1 1 0 Arginine/Serine-Rich protein 1 SR-25 PF10500.9 EXF79426.1 - 4.1 6.9 20.2 6.2 6.4 20.2 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein RAP1 PF07218.11 EXF79426.1 - 9.5 4.4 9.2 13 4.0 9.2 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Sec23_trunk PF04811.15 EXF79427.1 - 2.1e-50 171.6 0.0 5.5e-50 170.2 0.0 1.7 1 1 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 EXF79427.1 - 1.4e-24 85.9 0.1 2.4e-24 85.1 0.1 1.4 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.12 EXF79427.1 - 2.3e-17 63.5 0.0 4.4e-17 62.6 0.0 1.5 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 EXF79427.1 - 1.4e-14 53.9 4.9 2.9e-14 52.8 4.9 1.6 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 EXF79427.1 - 1.6e-05 24.7 0.0 4.3e-05 23.3 0.0 1.7 1 0 0 1 1 1 1 Gelsolin repeat DEK_C PF08766.11 EXF79427.1 - 0.054 13.4 0.1 0.098 12.6 0.1 1.4 1 0 0 1 1 1 0 DEK C terminal domain Lactamase_B_6 PF16661.5 EXF79428.1 - 1.7e-65 220.1 0.0 2.6e-65 219.5 0.0 1.3 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain CPSF100_C PF13299.6 EXF79428.1 - 1.1e-54 185.2 2.2 1.1e-54 185.2 2.2 2.6 3 0 0 3 3 3 1 Cleavage and polyadenylation factor 2 C-terminal RMMBL PF07521.12 EXF79428.1 - 1.5e-16 60.1 0.0 4.1e-16 58.7 0.0 1.8 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Beta-Casp PF10996.8 EXF79428.1 - 1.7e-16 60.5 0.0 1.5e-15 57.4 0.0 2.5 2 0 0 2 2 2 1 Beta-Casp domain Lactamase_B_2 PF12706.7 EXF79428.1 - 0.027 14.0 0.0 0.078 12.5 0.0 1.7 1 0 0 1 1 1 0 Beta-lactamase superfamily domain Lactamase_B PF00753.27 EXF79428.1 - 0.14 12.2 0.0 0.36 10.8 0.0 1.7 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily Fungal_trans PF04082.18 EXF79429.1 - 0.00015 20.9 0.0 0.00028 20.0 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Acetyltransf_2 PF00797.17 EXF79430.1 - 1.3e-41 143.0 0.1 1.6e-41 142.7 0.1 1.1 1 0 0 1 1 1 1 N-acetyltransferase DUF3830 PF12903.7 EXF79430.1 - 0.13 11.9 0.0 0.23 11.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3830) TIM PF00121.18 EXF79431.1 - 3.4e-54 183.8 0.0 3.8e-54 183.6 0.0 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase LacAB_rpiB PF02502.18 EXF79432.1 - 5.1e-43 146.4 0.3 5.8e-43 146.2 0.3 1.0 1 0 0 1 1 1 1 Ribose/Galactose Isomerase Dak1 PF02733.17 EXF79433.1 - 2.2e-97 325.7 0.0 2.9e-97 325.3 0.0 1.1 1 0 0 1 1 1 1 Dak1 domain Dak2 PF02734.17 EXF79433.1 - 2.7e-42 144.6 0.4 4.4e-42 143.9 0.4 1.4 1 0 0 1 1 1 1 DAK2 domain Fungal_trans PF04082.18 EXF79434.1 - 1.6e-20 73.3 0.0 2.6e-20 72.6 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF79434.1 - 0.2 11.8 16.7 0.56 10.4 16.7 1.8 1 1 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain ABC_tran_Xtn PF12848.7 EXF79434.1 - 1.2 9.2 5.4 1.4 9.0 0.6 2.3 2 0 0 2 2 2 0 ABC transporter Abhydrolase_6 PF12697.7 EXF79437.1 - 6.2e-18 66.2 0.0 8.4e-18 65.8 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EXF79437.1 - 3.7e-16 59.6 0.0 7.9e-16 58.5 0.1 1.5 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EXF79437.1 - 3e-09 36.5 0.0 4.9e-09 35.8 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 DUF915 PF06028.11 EXF79437.1 - 0.00024 20.5 0.0 0.026 13.9 0.0 2.2 2 0 0 2 2 2 1 Alpha/beta hydrolase of unknown function (DUF915) Thioesterase PF00975.20 EXF79437.1 - 0.00044 20.4 0.1 0.00072 19.7 0.1 1.3 1 0 0 1 1 1 1 Thioesterase domain Esterase PF00756.20 EXF79437.1 - 0.0011 18.7 0.2 0.0021 17.7 0.2 1.5 1 1 0 2 2 2 1 Putative esterase Lipase_3 PF01764.25 EXF79437.1 - 0.011 15.6 0.1 0.019 14.9 0.1 1.4 1 0 0 1 1 1 0 Lipase (class 3) Palm_thioest PF02089.15 EXF79437.1 - 0.013 15.4 0.0 0.017 15.0 0.0 1.2 1 0 0 1 1 1 0 Palmitoyl protein thioesterase Chlorophyllase PF07224.11 EXF79437.1 - 0.014 14.4 0.1 0.041 12.9 0.1 1.6 1 1 0 1 1 1 0 Chlorophyllase PGAP1 PF07819.13 EXF79437.1 - 0.093 12.4 0.0 0.14 11.8 0.0 1.2 1 0 0 1 1 1 0 PGAP1-like protein Abhydrolase_5 PF12695.7 EXF79437.1 - 0.12 12.2 0.0 0.21 11.3 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family UPF0227 PF05728.12 EXF79437.1 - 0.16 11.9 0.1 0.35 10.8 0.1 1.6 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0227) CFEM PF05730.11 EXF79438.1 - 1.7e-11 44.0 11.8 3.4e-11 43.1 11.8 1.5 1 0 0 1 1 1 1 CFEM domain NAD_binding_4 PF07993.12 EXF79439.1 - 6.4e-35 120.6 0.0 1.1e-34 119.8 0.0 1.4 1 0 0 1 1 1 1 Male sterility protein AMP-binding PF00501.28 EXF79439.1 - 1.4e-31 109.6 0.0 2.1e-31 108.9 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme Epimerase PF01370.21 EXF79439.1 - 1.5e-11 44.2 0.0 3.6e-11 43.0 0.0 1.6 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family PP-binding PF00550.25 EXF79439.1 - 1e-05 25.8 0.0 2.5e-05 24.5 0.0 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site MFS_1 PF07690.16 EXF79440.1 - 1.4e-33 116.3 16.2 1.7e-33 116.0 16.2 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF79440.1 - 2.2e-10 40.0 15.1 5.5e-10 38.7 15.1 1.5 1 1 0 1 1 1 1 Sugar (and other) transporter SfLAP PF11139.8 EXF79440.1 - 0.0028 17.1 7.3 0.14 11.6 1.6 2.5 2 0 0 2 2 2 2 Sap, sulfolipid-1-addressing protein DUF1772 PF08592.11 EXF79440.1 - 7 7.0 11.5 0.2 11.9 1.0 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF1772) Cu-oxidase_2 PF07731.14 EXF79441.1 - 2.1e-26 92.3 3.4 3.5e-24 85.1 1.7 2.5 2 0 0 2 2 2 2 Multicopper oxidase Cu-oxidase_3 PF07732.15 EXF79441.1 - 2e-18 66.5 0.0 5.9e-18 65.0 0.0 1.8 1 0 0 1 1 1 1 Multicopper oxidase Cu-oxidase PF00394.22 EXF79441.1 - 1.8e-05 24.9 0.0 0.0013 18.9 0.0 2.7 3 0 0 3 3 3 1 Multicopper oxidase DUF2555 PF10742.9 EXF79441.1 - 0.073 12.9 0.1 0.16 11.8 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2555) Glyco_hydro_11 PF00457.17 EXF79443.1 - 2.2e-82 275.0 23.9 2.6e-82 274.8 23.9 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 11 NPR3 PF03666.13 EXF79444.1 - 0.82 8.4 4.2 1 8.0 4.2 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF3807 PF12720.7 EXF79444.1 - 6.9 6.9 11.0 10 6.4 11.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) Presenilin PF01080.17 EXF79444.1 - 7.2 5.3 6.5 8.4 5.0 6.5 1.1 1 0 0 1 1 1 0 Presenilin Aminotran_1_2 PF00155.21 EXF79446.1 - 2.2e-16 60.0 0.0 2.8e-16 59.6 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.7 EXF79446.1 - 1.3e-05 24.2 0.0 4.4e-05 22.5 0.0 1.7 1 1 0 1 1 1 1 Alanine-glyoxylate amino-transferase DegT_DnrJ_EryC1 PF01041.17 EXF79446.1 - 0.018 14.4 0.1 0.044 13.1 0.0 1.6 2 0 0 2 2 2 0 DegT/DnrJ/EryC1/StrS aminotransferase family Fungal_trans PF04082.18 EXF79447.1 - 9.8e-05 21.5 0.1 0.00016 20.8 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain NAD_binding_10 PF13460.6 EXF79448.1 - 4.9e-11 42.9 0.3 8.7e-11 42.0 0.3 1.4 1 0 0 1 1 1 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 EXF79448.1 - 2.8e-08 34.1 0.2 2.8e-08 34.1 0.2 1.6 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain NmrA PF05368.13 EXF79448.1 - 6.7e-07 29.1 0.3 1.3e-06 28.2 0.3 1.5 1 1 0 1 1 1 1 NmrA-like family TrkA_N PF02254.18 EXF79448.1 - 7.7e-06 26.1 0.1 1.5e-05 25.2 0.1 1.5 1 0 0 1 1 1 1 TrkA-N domain Epimerase PF01370.21 EXF79448.1 - 1.3e-05 24.8 0.1 0.0042 16.6 0.1 2.2 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EXF79448.1 - 3.1e-05 23.1 0.0 0.00068 18.7 0.1 2.1 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 EXF79448.1 - 3.8e-05 23.0 0.1 0.0037 16.5 0.1 2.4 2 1 0 2 2 2 1 Male sterility protein GDP_Man_Dehyd PF16363.5 EXF79448.1 - 0.0018 17.7 0.0 0.2 11.0 0.0 2.2 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase F420_oxidored PF03807.17 EXF79448.1 - 0.0024 18.4 0.1 0.0053 17.3 0.1 1.7 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Semialdhyde_dh PF01118.24 EXF79448.1 - 0.0048 17.3 0.0 0.0091 16.4 0.0 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 EXF79448.1 - 0.01 15.9 0.0 0.018 15.1 0.0 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Polysacc_synt_2 PF02719.15 EXF79448.1 - 0.024 13.8 0.0 0.038 13.1 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein KR PF08659.10 EXF79448.1 - 0.07 13.0 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 KR domain MFS_1 PF07690.16 EXF79449.1 - 1.2e-24 86.9 33.5 1.4e-24 86.7 33.5 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily CoA_transf_3 PF02515.17 EXF79450.1 - 9.4e-109 363.9 0.0 1.1e-108 363.7 0.0 1.0 1 0 0 1 1 1 1 CoA-transferase family III RisS_PPD PF16524.5 EXF79450.1 - 0.13 12.5 0.1 0.25 11.6 0.1 1.4 1 0 0 1 1 1 0 Periplasmic domain of Sensor histidine kinase RisS Acyl-CoA_dh_1 PF00441.24 EXF79451.1 - 3.4e-31 108.5 2.4 6.4e-31 107.6 2.4 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 EXF79451.1 - 2.1e-20 72.7 0.0 4.2e-20 71.8 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 EXF79451.1 - 3e-20 73.0 0.1 6.4e-20 71.9 0.1 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 EXF79451.1 - 8.8e-16 58.4 5.2 1.7e-15 57.5 3.3 2.1 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Fungal_trans PF04082.18 EXF79452.1 - 9.2e-30 103.6 0.0 1.3e-29 103.0 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF79452.1 - 3.1e-07 30.4 10.0 7.1e-07 29.2 10.0 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MaoC_dehydrat_N PF13452.6 EXF79453.1 - 0.0048 17.0 0.0 0.019 15.1 0.0 1.9 2 0 0 2 2 2 1 N-terminal half of MaoC dehydratase DUF1929 PF09118.11 EXF79453.1 - 0.14 12.5 0.0 0.36 11.1 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1929) FAD_binding_3 PF01494.19 EXF79454.1 - 8e-14 51.6 1.8 2.8e-10 40.0 0.4 2.8 2 1 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 EXF79454.1 - 0.0044 17.2 0.2 0.01 16.0 0.2 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EXF79454.1 - 0.019 14.2 1.0 0.14 11.4 1.1 2.3 2 1 1 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EXF79454.1 - 0.037 13.6 0.1 0.32 10.5 0.1 2.2 3 0 0 3 3 3 0 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EXF79454.1 - 0.084 11.9 0.3 0.16 11.0 0.3 1.4 1 0 0 1 1 1 0 FAD binding domain ApbA PF02558.16 EXF79454.1 - 0.16 11.6 0.0 0.33 10.6 0.0 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA TrkA_N PF02254.18 EXF79454.1 - 0.21 11.9 0.1 0.46 10.7 0.1 1.5 1 0 0 1 1 1 0 TrkA-N domain Lactamase_B PF00753.27 EXF79455.1 - 2e-07 31.2 0.7 3e-07 30.6 0.7 1.3 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_3 PF13483.6 EXF79455.1 - 7.6e-07 29.2 0.0 1.8e-05 24.7 0.0 2.2 2 0 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B_2 PF12706.7 EXF79455.1 - 6.4e-06 25.8 0.0 1.2e-05 25.0 0.0 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain AZUL PF16558.5 EXF79456.1 - 0.016 15.4 0.9 0.039 14.2 0.9 1.7 1 1 0 1 1 1 0 Amino-terminal Zinc-binding domain of ubiquitin ligase E3A CBP PF12192.8 EXF79456.1 - 0.065 13.4 3.2 0.1 12.8 3.2 1.3 1 0 0 1 1 1 0 Fungal calcium binding protein NOA36 PF06524.12 EXF79456.1 - 0.27 10.5 2.3 0.31 10.3 2.3 1.1 1 0 0 1 1 1 0 NOA36 protein Pectinesterase PF01095.19 EXF79459.1 - 9.1e-48 162.5 4.6 1.2e-47 162.1 4.6 1.1 1 0 0 1 1 1 1 Pectinesterase MFS_1 PF07690.16 EXF79461.1 - 9.4e-35 120.2 24.8 1.4e-34 119.6 24.8 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Trp_oprn_chp PF09534.10 EXF79461.1 - 0.018 14.8 4.0 0.83 9.4 0.1 2.8 2 1 1 3 3 3 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Amidase PF01425.21 EXF79462.1 - 3.7e-46 158.0 0.0 3.3e-43 148.3 0.1 2.3 2 1 0 2 2 2 2 Amidase Pkinase PF00069.25 EXF79464.1 - 2.4e-19 69.7 0.0 2.2e-08 33.8 0.0 2.6 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EXF79464.1 - 9.8e-08 31.6 3.0 0.0085 15.4 0.5 3.3 3 1 0 3 3 3 2 Protein tyrosine kinase APH PF01636.23 EXF79464.1 - 0.0076 16.2 0.3 0.39 10.6 0.1 3.0 2 1 0 3 3 3 1 Phosphotransferase enzyme family TrkA_TMD PF18613.1 EXF79464.1 - 2 7.9 4.1 4.2 6.9 4.1 1.4 1 0 0 1 1 1 0 Tyrosine kinase receptor A trans-membrane domain MFS_1 PF07690.16 EXF79465.1 - 3.2e-34 118.4 29.9 3.2e-34 118.4 29.9 1.7 2 0 0 2 2 2 1 Major Facilitator Superfamily TMEM100 PF16311.5 EXF79465.1 - 0.18 11.4 0.6 16 5.0 0.0 2.4 2 0 0 2 2 2 0 Transmembrane protein 100 DUF4231 PF14015.6 EXF79465.1 - 3.8 8.0 5.9 10 6.7 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) dCMP_cyt_deam_1 PF00383.23 EXF79467.1 - 8.7e-08 32.0 0.0 1.1e-07 31.7 0.0 1.1 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EXF79467.1 - 1.1e-06 28.5 0.0 1.4e-06 28.1 0.0 1.1 1 0 0 1 1 1 1 MafB19-like deaminase Terpene_synth_C PF03936.16 EXF79468.1 - 3.6e-08 33.1 0.3 4.7e-08 32.7 0.3 1.1 1 0 0 1 1 1 1 Terpene synthase family, metal binding domain CCDC50_N PF15295.6 EXF79468.1 - 0.045 13.9 0.0 0.087 13.0 0.0 1.4 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 50 N-terminus p450 PF00067.22 EXF79469.1 - 1e-57 196.0 0.0 1.1e-57 195.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Tannase PF07519.11 EXF79470.1 - 1.1e-112 377.4 0.2 1.3e-112 377.2 0.2 1.1 1 0 0 1 1 1 1 Tannase and feruloyl esterase Hydrolase_4 PF12146.8 EXF79470.1 - 0.013 14.8 0.0 0.6 9.3 0.0 2.2 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 EXF79470.1 - 0.096 12.1 0.6 1.6 8.1 0.0 2.2 2 0 0 2 2 2 0 Prolyl oligopeptidase family Ank_2 PF12796.7 EXF79471.1 - 8.2e-64 212.2 0.0 2.3e-11 44.1 0.0 10.0 4 3 7 11 11 11 9 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EXF79471.1 - 7.2e-47 157.2 5.4 2.3e-07 31.2 0.2 12.4 9 3 3 12 12 12 9 Ankyrin repeats (many copies) Ank_3 PF13606.6 EXF79471.1 - 8.3e-43 139.5 9.1 0.00078 19.7 0.0 16.0 19 0 0 19 19 17 9 Ankyrin repeat Ank_5 PF13857.6 EXF79471.1 - 1.7e-40 136.6 1.9 1.6e-05 25.1 0.0 14.2 10 3 5 15 15 15 6 Ankyrin repeats (many copies) Ank PF00023.30 EXF79471.1 - 1.5e-39 132.7 9.9 3.3e-05 24.1 0.0 15.3 17 0 0 17 17 15 7 Ankyrin repeat NACHT PF05729.12 EXF79471.1 - 1.3e-07 31.7 0.0 4e-07 30.1 0.0 1.8 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 EXF79471.1 - 0.0012 19.3 0.0 0.0034 17.8 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 EXF79471.1 - 0.059 13.8 0.0 0.22 11.9 0.0 1.9 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Bac_DnaA PF00308.18 EXF79471.1 - 0.092 12.6 0.0 0.2 11.5 0.0 1.5 1 0 0 1 1 1 0 Bacterial dnaA protein TsaE PF02367.17 EXF79471.1 - 0.14 12.1 0.0 0.39 10.7 0.0 1.7 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATPase_2 PF01637.18 EXF79471.1 - 0.15 12.0 0.0 0.35 10.8 0.0 1.6 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea IstB_IS21 PF01695.17 EXF79471.1 - 0.16 11.7 0.1 0.36 10.6 0.1 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein ATP-synt_ab PF00006.25 EXF79471.1 - 0.17 11.5 0.0 5.5 6.6 0.0 2.9 2 1 1 3 3 3 0 ATP synthase alpha/beta family, nucleotide-binding domain C1_1 PF00130.22 EXF79471.1 - 2.3 8.2 5.2 5.8 6.9 5.2 1.7 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) XPG_I PF00867.18 EXF79472.1 - 2e-30 105.0 1.3 2.9e-30 104.5 0.0 1.9 2 0 0 2 2 2 1 XPG I-region XPG_N PF00752.17 EXF79472.1 - 2.1e-29 101.9 0.0 5.6e-29 100.6 0.0 1.8 1 0 0 1 1 1 1 XPG N-terminal domain 5_3_exonuc PF01367.20 EXF79472.1 - 6.3e-06 26.7 0.3 0.00012 22.6 0.0 2.8 2 0 0 2 2 2 1 5'-3' exonuclease, C-terminal SAM fold HHH_2 PF12826.7 EXF79472.1 - 0.065 13.3 0.0 0.19 11.8 0.0 1.8 1 0 0 1 1 1 0 Helix-hairpin-helix motif Acyl-CoA_dh_1 PF00441.24 EXF79473.1 - 3.7e-41 140.8 0.3 5.4e-41 140.3 0.3 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 EXF79473.1 - 2.5e-20 72.5 0.1 4.2e-20 71.8 0.1 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Cyt-b5 PF00173.28 EXF79473.1 - 4.6e-20 71.5 0.4 8.2e-20 70.7 0.4 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Acyl-CoA_dh_N PF02771.16 EXF79473.1 - 1.2e-17 64.5 0.0 2.6e-17 63.5 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 EXF79473.1 - 9.2e-08 32.4 0.0 1.5e-07 31.8 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain YidD PF01809.18 EXF79474.1 - 8.3 6.4 8.3 0.72 9.8 0.4 2.4 2 0 0 2 2 2 0 Putative membrane protein insertion efficiency factor Dabb PF07876.12 EXF79475.1 - 2.4e-20 73.0 0.0 2.7e-20 72.8 0.0 1.0 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain DUF1871 PF08958.10 EXF79475.1 - 0.13 12.6 0.1 1.1 9.6 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1871) E1_DerP2_DerF2 PF02221.15 EXF79477.1 - 3.9e-28 98.5 0.7 4.7e-28 98.3 0.7 1.1 1 0 0 1 1 1 1 ML domain Big_9 PF17963.1 EXF79477.1 - 0.014 16.1 0.1 0.029 15.1 0.0 1.5 2 0 0 2 2 2 0 Bacterial Ig domain ATP-synt_F PF01990.17 EXF79478.1 - 3e-34 117.2 0.1 3.4e-34 117.0 0.1 1.0 1 0 0 1 1 1 1 ATP synthase (F/14-kDa) subunit DUF2418 PF10332.9 EXF79479.1 - 3.7e-39 133.2 0.7 5.9e-38 129.3 0.6 2.6 3 0 0 3 3 3 1 Protein of unknown function (DUF2418) MCM_N PF14551.6 EXF79481.1 - 0.081 13.5 0.0 0.14 12.7 0.0 1.4 1 0 0 1 1 1 0 MCM N-terminal domain PIEZO PF15917.5 EXF79482.1 - 2.1 7.8 17.7 0.28 10.6 8.8 2.4 2 0 0 2 2 2 0 Piezo Aconitase PF00330.20 EXF79483.1 - 4.3e-160 533.7 0.0 6.5e-160 533.1 0.0 1.3 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 EXF79483.1 - 3.7e-39 134.1 0.0 7.4e-39 133.1 0.0 1.5 1 0 0 1 1 1 1 Aconitase C-terminal domain Methyltransf_16 PF10294.9 EXF79484.1 - 2.5e-10 40.4 0.0 0.00037 20.3 0.0 2.2 2 0 0 2 2 2 2 Lysine methyltransferase SSP160 PF06933.11 EXF79484.1 - 3.2 5.8 14.0 5.3 5.1 14.0 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 NQR2_RnfD_RnfE PF03116.15 EXF79485.1 - 0.043 13.2 0.0 0.062 12.7 0.0 1.2 1 0 0 1 1 1 0 NQR2, RnfD, RnfE family Enterotoxin_a PF01375.17 EXF79486.1 - 1.3e-45 156.0 0.2 1.7e-45 155.7 0.2 1.0 1 0 0 1 1 1 1 Heat-labile enterotoxin alpha chain MFS_1 PF07690.16 EXF79487.1 - 2.2e-33 115.6 55.0 3.1e-24 85.6 25.3 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2975 PF11188.8 EXF79487.1 - 0.018 14.9 0.1 0.018 14.9 0.1 4.2 3 2 1 4 4 4 0 Protein of unknown function (DUF2975) MFS_1_like PF12832.7 EXF79487.1 - 0.037 12.9 0.1 0.037 12.9 0.1 3.1 2 1 0 3 3 3 0 MFS_1 like family Dynamin_N PF00350.23 EXF79488.1 - 5.3e-33 114.5 0.0 1.6e-32 112.8 0.0 1.9 2 0 0 2 2 2 1 Dynamin family Dynamin_M PF01031.20 EXF79488.1 - 2e-25 89.6 0.0 3.6e-22 78.9 0.0 2.2 2 0 0 2 2 2 2 Dynamin central region MMR_HSR1 PF01926.23 EXF79488.1 - 9.4e-05 22.5 0.0 0.00054 20.0 0.0 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 EXF79488.1 - 0.025 15.0 0.6 0.12 12.7 0.0 2.4 2 1 0 2 2 2 0 AAA ATPase domain FeoB_N PF02421.18 EXF79488.1 - 0.16 11.5 0.0 9.5 5.7 0.0 2.3 2 0 0 2 2 2 0 Ferrous iron transport protein B His_Phos_2 PF00328.22 EXF79489.1 - 1.6e-68 231.9 0.0 1.9e-68 231.6 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) RCR PF12273.8 EXF79490.1 - 0.032 14.9 9.1 0.83 10.3 9.2 2.7 1 1 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red Bromodomain PF00439.25 EXF79491.1 - 3e-16 59.3 0.0 7.4e-16 58.0 0.0 1.8 1 0 0 1 1 1 1 Bromodomain BTB PF00651.31 EXF79491.1 - 0.00059 20.0 0.0 0.0023 18.1 0.0 2.0 2 0 0 2 2 2 1 BTB/POZ domain Hamartin PF04388.12 EXF79491.1 - 0.027 13.2 1.0 0.036 12.7 1.0 1.3 1 0 0 1 1 1 0 Hamartin protein Ribonuclease_T2 PF00445.18 EXF79492.1 - 3e-34 118.9 0.5 4.2e-34 118.4 0.5 1.2 1 0 0 1 1 1 1 Ribonuclease T2 family Sec62 PF03839.16 EXF79493.1 - 8.7e-71 237.9 1.2 8.7e-71 237.9 1.2 2.0 2 0 0 2 2 2 1 Translocation protein Sec62 DUF4834 PF16118.5 EXF79493.1 - 0.72 10.9 9.2 47 5.0 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) Corona_M PF01635.18 EXF79493.1 - 1 8.6 6.6 1.6 8.0 6.6 1.2 1 0 0 1 1 1 0 Coronavirus M matrix/glycoprotein TFIIA PF03153.13 EXF79493.1 - 1.9 8.4 20.5 0.11 12.5 15.6 1.5 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit PAT1 PF09770.9 EXF79493.1 - 3.5 5.8 18.6 4.6 5.4 18.6 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Neur_chan_memb PF02932.16 EXF79493.1 - 4.9 7.1 4.8 9.9 6.1 4.8 1.6 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region SelP_N PF04592.14 EXF79493.1 - 6.2 6.2 18.7 13 5.1 18.7 1.4 1 0 0 1 1 1 0 Selenoprotein P, N terminal region E1-E2_ATPase PF00122.20 EXF79495.1 - 3.9e-49 166.6 6.5 3.9e-49 166.6 6.5 2.9 3 0 0 3 3 3 1 E1-E2 ATPase Hydrolase PF00702.26 EXF79495.1 - 7.2e-28 98.3 1.8 9e-28 98.0 0.5 1.8 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HMA PF00403.26 EXF79495.1 - 3.3e-11 43.5 0.0 1.6e-09 38.1 0.0 3.0 2 0 0 2 2 2 1 Heavy-metal-associated domain CoA_binding_2 PF13380.6 EXF79495.1 - 0.0096 16.4 0.2 0.029 14.9 0.2 1.9 1 0 0 1 1 1 1 CoA binding domain Hydrolase_3 PF08282.12 EXF79495.1 - 0.046 13.5 1.5 5.4 6.7 0.1 2.4 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase Phage_stabilise PF11134.8 EXF79495.1 - 0.13 11.0 0.2 0.22 10.3 0.2 1.2 1 0 0 1 1 1 0 Phage stabilisation protein OPT PF03169.15 EXF79497.1 - 2.8e-204 680.3 40.4 3.3e-204 680.1 40.4 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein PBP_GOBP PF01395.22 EXF79498.1 - 0.088 13.0 0.0 0.16 12.1 0.0 1.3 1 0 0 1 1 1 0 PBP/GOBP family NPP1 PF05630.11 EXF79499.1 - 2.2e-42 145.4 0.0 2.8e-42 145.1 0.0 1.1 1 0 0 1 1 1 1 Necrosis inducing protein (NPP1) GFO_IDH_MocA PF01408.22 EXF79500.1 - 1.7e-20 74.0 0.1 3.8e-20 72.9 0.0 1.5 2 0 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 EXF79500.1 - 3.7e-07 30.2 0.0 8e-07 29.1 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain NAD_binding_3 PF03447.16 EXF79500.1 - 0.00086 19.9 0.0 0.0018 18.9 0.0 1.5 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain AAA_33 PF13671.6 EXF79500.1 - 0.0011 19.2 0.0 0.0021 18.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain DUF1593 PF07632.11 EXF79501.1 - 5.4e-84 281.7 0.1 6.9e-84 281.3 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1593) REJ PF02010.15 EXF79501.1 - 0.027 13.3 0.0 0.04 12.7 0.0 1.2 1 0 0 1 1 1 0 REJ domain Pilin PF00114.19 EXF79502.1 - 0.033 15.1 0.3 0.036 15.0 0.3 1.1 1 0 0 1 1 1 0 Pilin (bacterial filament) Peptidase_M14 PF00246.24 EXF79503.1 - 2e-82 277.3 0.2 2.4e-82 277.0 0.2 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase CorA PF01544.18 EXF79504.1 - 1.1e-42 146.4 0.1 1.6e-42 145.9 0.1 1.2 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein p450 PF00067.22 EXF79505.1 - 2e-61 208.2 0.0 2.7e-61 207.7 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 Transferase PF02458.15 EXF79505.1 - 1e-21 77.1 0.0 1.8e-15 56.6 0.0 2.2 2 0 0 2 2 2 2 Transferase family Cyt-b5 PF00173.28 EXF79506.1 - 5.3e-20 71.3 0.2 7.3e-20 70.9 0.2 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain KR PF08659.10 EXF79508.1 - 2.2e-60 203.7 0.4 5e-60 202.5 0.4 1.7 1 0 0 1 1 1 1 KR domain PS-DH PF14765.6 EXF79508.1 - 4.9e-56 190.2 0.0 8e-56 189.4 0.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 EXF79508.1 - 1.4e-49 169.3 0.5 3.3e-49 168.1 0.1 1.9 2 0 0 2 2 2 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EXF79508.1 - 3.5e-35 120.6 0.0 8.4e-35 119.3 0.0 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain ketoacyl-synt PF00109.26 EXF79508.1 - 5.2e-35 121.2 0.1 5e-20 72.2 0.0 2.6 2 0 0 2 2 2 2 Beta-ketoacyl synthase, N-terminal domain KAsynt_C_assoc PF16197.5 EXF79508.1 - 5.7e-19 68.6 0.0 1.5e-18 67.2 0.0 1.8 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension adh_short PF00106.25 EXF79508.1 - 6e-11 42.2 0.8 4e-10 39.5 0.1 2.3 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF79508.1 - 2e-07 30.8 0.0 4.7e-07 29.6 0.0 1.6 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase PP-binding PF00550.25 EXF79508.1 - 0.00012 22.4 0.1 0.00029 21.1 0.1 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site ADH_zinc_N PF00107.26 EXF79508.1 - 0.0039 17.2 0.0 0.011 15.7 0.0 1.8 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Epimerase PF01370.21 EXF79508.1 - 0.0099 15.4 0.2 1.6 8.2 0.0 2.5 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family ADH_zinc_N_2 PF13602.6 EXF79508.1 - 0.091 13.8 0.0 0.34 12.0 0.0 2.0 1 0 0 1 1 1 0 Zinc-binding dehydrogenase FSH1 PF03959.13 EXF79509.1 - 1.3e-26 93.6 0.3 1.4e-25 90.3 0.3 2.3 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_2 PF02230.16 EXF79509.1 - 0.023 14.5 0.1 0.34 10.7 0.1 2.2 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase MFS_1 PF07690.16 EXF79510.1 - 5.4e-41 140.7 39.0 5.4e-41 140.7 39.0 1.7 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EXF79510.1 - 8.3e-09 34.4 23.4 1.4e-08 33.6 23.4 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) ketoacyl-synt PF00109.26 EXF79511.1 - 5.2e-69 232.6 0.0 9.5e-69 231.8 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain PS-DH PF14765.6 EXF79511.1 - 4.4e-58 196.9 0.0 7.9e-58 196.0 0.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase KR PF08659.10 EXF79511.1 - 4.9e-57 192.7 0.1 4.8e-56 189.5 0.0 2.7 4 0 0 4 4 4 1 KR domain Acyl_transf_1 PF00698.21 EXF79511.1 - 1.5e-45 156.1 0.0 2.5e-45 155.4 0.0 1.3 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EXF79511.1 - 1.7e-39 134.5 0.1 4.9e-39 133.0 0.1 1.9 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Methyltransf_12 PF08242.12 EXF79511.1 - 6.9e-20 71.6 0.0 2.7e-19 69.7 0.0 2.1 2 0 0 2 2 1 1 Methyltransferase domain ADH_zinc_N_2 PF13602.6 EXF79511.1 - 1e-19 71.9 0.0 3.9e-18 66.8 0.0 2.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase KAsynt_C_assoc PF16197.5 EXF79511.1 - 2e-16 60.4 0.0 5.4e-16 59.0 0.0 1.7 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension ADH_zinc_N PF00107.26 EXF79511.1 - 3.1e-16 59.5 0.4 1.3e-15 57.5 0.2 2.2 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Methyltransf_23 PF13489.6 EXF79511.1 - 2.4e-11 43.7 0.0 6e-11 42.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF79511.1 - 1.3e-10 41.8 0.0 7.3e-10 39.4 0.0 2.4 1 0 0 1 1 1 1 Methyltransferase domain adh_short PF00106.25 EXF79511.1 - 4.3e-10 39.4 0.0 4.1e-08 32.9 0.0 2.5 2 0 0 2 2 2 1 short chain dehydrogenase Methyltransf_11 PF08241.12 EXF79511.1 - 2.3e-09 37.8 0.0 9.2e-09 35.8 0.0 2.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF79511.1 - 3.5e-07 30.1 0.0 1.1e-06 28.5 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain adh_short_C2 PF13561.6 EXF79511.1 - 1.8e-06 27.7 0.0 2.8e-05 23.8 0.0 2.4 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase Ubie_methyltran PF01209.18 EXF79511.1 - 1.4e-05 24.5 0.0 2.7e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family PP-binding PF00550.25 EXF79511.1 - 0.0018 18.6 0.1 0.0056 17.0 0.1 1.9 1 0 0 1 1 1 1 Phosphopantetheine attachment site ADH_N PF08240.12 EXF79511.1 - 0.0049 16.7 0.0 0.011 15.6 0.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Methyltransf_16 PF10294.9 EXF79511.1 - 0.044 13.5 0.0 0.1 12.3 0.0 1.5 1 0 0 1 1 1 0 Lysine methyltransferase Sacchrp_dh_NADP PF03435.18 EXF79511.1 - 0.061 13.6 0.0 0.22 11.8 0.0 2.0 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Thiolase_N PF00108.23 EXF79511.1 - 0.11 11.8 0.1 0.39 10.0 0.1 1.9 1 0 0 1 1 1 0 Thiolase, N-terminal domain Spermine_synth PF01564.17 EXF79511.1 - 0.14 11.5 0.5 0.54 9.6 0.1 2.0 2 0 0 2 2 2 0 Spermine/spermidine synthase domain p450 PF00067.22 EXF79513.1 - 4.9e-63 213.5 0.0 6.7e-63 213.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 TauD PF02668.16 EXF79514.1 - 1.5e-60 205.3 0.5 1.8e-60 205.0 0.5 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family MFS_1 PF07690.16 EXF79515.1 - 2e-30 106.0 13.2 2e-30 106.0 13.2 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily MFS_4 PF06779.14 EXF79515.1 - 0.0021 17.4 0.4 0.0035 16.7 0.4 1.4 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB A_deaminase PF00962.22 EXF79516.1 - 2.1e-38 132.5 0.0 3.1e-38 131.9 0.0 1.2 1 0 0 1 1 1 1 Adenosine/AMP deaminase Amidohydro_1 PF01979.20 EXF79516.1 - 0.17 11.2 0.0 0.46 9.7 0.0 1.8 2 1 0 2 2 2 0 Amidohydrolase family MFS_1 PF07690.16 EXF79517.1 - 1.4e-30 106.4 31.7 2e-30 106.0 31.7 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_4 PF06779.14 EXF79517.1 - 1.4e-06 27.9 4.7 1.4e-06 27.9 4.7 2.2 2 0 0 2 2 2 2 Uncharacterised MFS-type transporter YbfB SfLAP PF11139.8 EXF79517.1 - 0.0097 15.4 0.2 0.0097 15.4 0.2 2.5 2 0 0 2 2 2 1 Sap, sulfolipid-1-addressing protein DUF2196 PF09962.9 EXF79518.1 - 1.1e-20 73.4 3.0 2.1e-20 72.5 3.0 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2196) Zn-C2H2_12 PF18112.1 EXF79518.1 - 4.6 7.8 6.3 25 5.4 6.3 2.0 1 1 0 1 1 1 0 Autophagy receptor zinc finger-C2H2 domain Exo5 PF09810.9 EXF79521.1 - 7.4e-140 466.6 0.0 8.9e-140 466.3 0.0 1.1 1 0 0 1 1 1 1 Exonuclease V - a 5' deoxyribonuclease PDDEXK_1 PF12705.7 EXF79521.1 - 0.023 14.6 0.2 2.6 7.9 0.0 2.8 2 1 0 2 2 2 0 PD-(D/E)XK nuclease superfamily Methyltransf_23 PF13489.6 EXF79524.1 - 9.5e-18 64.6 0.0 1.6e-17 63.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF79524.1 - 5e-11 43.2 0.0 1e-10 42.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF79524.1 - 5.8e-09 35.9 0.0 2.8e-08 33.7 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF79524.1 - 4.7e-08 33.6 0.0 1.1e-07 32.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF79524.1 - 2.7e-06 28.0 0.0 4.1e-05 24.3 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EXF79524.1 - 0.00035 20.0 0.0 0.00049 19.6 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Ubie_methyltran PF01209.18 EXF79524.1 - 0.0051 16.2 0.0 0.032 13.6 0.0 1.9 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family FtsJ PF01728.19 EXF79524.1 - 0.012 15.7 0.0 0.02 15.0 0.0 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase MTS PF05175.14 EXF79524.1 - 0.028 14.0 0.0 0.075 12.6 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_16 PF10294.9 EXF79524.1 - 0.053 13.2 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 Lysine methyltransferase CheR PF01739.18 EXF79524.1 - 0.11 12.0 0.0 0.2 11.1 0.0 1.4 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain Zn_clus PF00172.18 EXF79525.1 - 3.6e-07 30.2 9.9 3.6e-07 30.2 9.9 2.3 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EXF79525.1 - 0.07 11.9 0.0 0.12 11.2 0.0 1.3 1 0 0 1 1 1 0 Fungal specific transcription factor domain TPR_MalT PF17874.1 EXF79525.1 - 0.19 11.0 0.0 0.34 10.2 0.0 1.3 1 0 0 1 1 1 0 MalT-like TPR region Tannase PF07519.11 EXF79526.1 - 3.9e-98 329.4 5.7 4.5e-98 329.2 5.7 1.0 1 0 0 1 1 1 1 Tannase and feruloyl esterase F-box-like PF12937.7 EXF79528.1 - 0.0053 16.6 0.1 0.2 11.6 0.0 2.7 2 0 0 2 2 2 1 F-box-like Pyrid_ox_like PF16242.5 EXF79529.1 - 2.2e-22 79.2 0.0 3.3e-22 78.7 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase like Putative_PNPOx PF01243.20 EXF79529.1 - 3.7e-08 33.4 0.0 7e-08 32.6 0.0 1.4 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase TP_methylase PF00590.20 EXF79530.1 - 7.3e-23 81.6 0.3 1.3e-22 80.8 0.3 1.4 1 1 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases zf-C2H2_jaz PF12171.8 EXF79531.1 - 4.8e-07 29.9 0.1 7.8e-07 29.2 0.1 1.4 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EXF79531.1 - 4.9e-05 23.6 0.1 8.3e-05 22.8 0.1 1.4 1 0 0 1 1 1 1 Zinc-finger of C2H2 type SNRNP27 PF08648.12 EXF79531.1 - 0.0022 18.0 0.7 0.0022 18.0 0.7 2.0 2 0 0 2 2 2 1 U4/U6.U5 small nuclear ribonucleoproteins zf-DBF PF07535.12 EXF79531.1 - 0.0052 16.9 0.1 0.0099 16.0 0.1 1.4 1 0 0 1 1 1 1 DBF zinc finger zf-C2H2 PF00096.26 EXF79531.1 - 0.1 13.1 0.4 0.17 12.4 0.4 1.4 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-U1 PF06220.12 EXF79531.1 - 0.15 11.9 0.1 0.33 10.7 0.1 1.5 1 0 0 1 1 1 0 U1 zinc finger Exonuc_VII_L PF02601.15 EXF79531.1 - 0.88 9.1 7.2 1.4 8.4 7.2 1.3 1 1 0 1 1 1 0 Exonuclease VII, large subunit DDHD PF02862.17 EXF79531.1 - 2 8.5 5.1 0.42 10.7 1.7 1.5 2 0 0 2 2 2 0 DDHD domain UQ_con PF00179.26 EXF79532.1 - 8.9e-35 119.4 0.0 1.1e-34 119.1 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EXF79532.1 - 0.045 13.4 0.0 0.081 12.6 0.0 1.4 1 1 0 1 1 1 0 Prokaryotic E2 family B ETX_MTX2 PF03318.13 EXF79533.1 - 0.0011 18.8 5.3 0.0025 17.6 5.3 1.6 1 0 0 1 1 1 1 Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2 Aerolysin PF01117.20 EXF79533.1 - 0.0015 17.8 0.9 0.0022 17.3 0.9 1.2 1 0 0 1 1 1 1 Aerolysin toxin HET PF06985.11 EXF79534.1 - 4.8e-33 114.6 6.2 7.7e-33 113.9 6.2 1.3 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) DUF4797 PF16051.5 EXF79534.1 - 0.35 10.8 1.2 13 5.8 0.6 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4797) RTA1 PF04479.13 EXF79535.1 - 2.7e-65 219.9 16.6 2.7e-65 219.9 16.6 1.7 1 1 1 2 2 2 1 RTA1 like protein Kei1 PF08552.11 EXF79535.1 - 0.0014 18.5 0.1 0.0033 17.3 0.1 1.6 1 0 0 1 1 1 1 Inositolphosphorylceramide synthase subunit Kei1 Caveolin PF01146.17 EXF79535.1 - 0.24 11.4 4.3 0.13 12.2 0.8 2.3 2 0 0 2 2 2 0 Caveolin F-box-like PF12937.7 EXF79536.1 - 0.07 13.0 0.2 0.18 11.7 0.2 1.7 1 0 0 1 1 1 0 F-box-like adh_short_C2 PF13561.6 EXF79537.1 - 1.2e-61 208.3 0.0 1.3e-61 208.1 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF79537.1 - 2.2e-46 157.8 0.0 2.7e-46 157.5 0.0 1.0 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EXF79537.1 - 1.7e-10 41.1 0.2 2.3e-10 40.7 0.2 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EXF79537.1 - 1.2e-05 24.9 0.0 0.021 14.3 0.0 2.0 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family Ldh_1_N PF00056.23 EXF79537.1 - 0.00041 20.5 0.0 0.00065 19.8 0.0 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain p450 PF00067.22 EXF79538.1 - 8.6e-47 159.9 0.0 4.7e-34 117.9 0.0 2.2 2 0 0 2 2 2 2 Cytochrome P450 F-box-like PF12937.7 EXF79539.1 - 0.046 13.6 0.0 0.068 13.1 0.0 1.2 1 0 0 1 1 1 0 F-box-like Peptidase_S10 PF00450.22 EXF79540.1 - 8.4e-66 223.1 0.0 1.1e-65 222.7 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase Abhydrolase_6 PF12697.7 EXF79540.1 - 0.0041 17.8 0.1 0.022 15.3 0.0 1.9 1 1 0 2 2 2 1 Alpha/beta hydrolase family NmrA PF05368.13 EXF79541.1 - 4.8e-33 114.7 0.0 1.1e-32 113.5 0.0 1.6 1 1 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EXF79541.1 - 3.3e-12 46.7 0.0 4.6e-12 46.2 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EXF79541.1 - 5.9e-06 25.9 0.1 1.2e-05 24.9 0.1 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family adh_short PF00106.25 EXF79541.1 - 0.00014 21.4 0.2 0.00033 20.2 0.1 1.6 2 0 0 2 2 2 1 short chain dehydrogenase GDP_Man_Dehyd PF16363.5 EXF79541.1 - 0.00016 21.2 0.0 0.00039 19.9 0.0 1.6 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase F420_oxidored PF03807.17 EXF79541.1 - 0.0044 17.6 0.1 0.011 16.3 0.1 1.7 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Sacchrp_dh_NADP PF03435.18 EXF79541.1 - 0.0058 16.9 0.0 0.0093 16.2 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain 3Beta_HSD PF01073.19 EXF79541.1 - 0.012 14.6 0.0 0.02 13.9 0.0 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family KR PF08659.10 EXF79541.1 - 0.035 14.0 0.1 0.073 13.0 0.1 1.4 1 0 0 1 1 1 0 KR domain adh_short_C2 PF13561.6 EXF79541.1 - 0.14 11.6 0.2 0.86 9.1 0.1 2.0 1 1 1 2 2 2 0 Enoyl-(Acyl carrier protein) reductase Methyltransf_23 PF13489.6 EXF79542.1 - 1.1e-19 70.8 0.0 1.7e-19 70.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF79542.1 - 3.3e-11 43.8 0.0 7.1e-11 42.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF79542.1 - 5.8e-10 39.2 0.1 8.6e-09 35.4 0.1 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF79542.1 - 2.9e-07 31.0 0.0 6.8e-07 29.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF79542.1 - 1.1e-05 26.0 0.0 3.9e-05 24.3 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EXF79542.1 - 0.0065 16.0 0.0 0.012 15.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 EXF79542.1 - 0.009 15.4 0.0 0.013 14.9 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) CMAS PF02353.20 EXF79542.1 - 0.013 14.8 0.0 0.027 13.8 0.0 1.6 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_16 PF10294.9 EXF79542.1 - 0.014 15.2 0.0 0.031 14.0 0.0 1.6 2 0 0 2 2 2 0 Lysine methyltransferase Methyltransf_4 PF02390.17 EXF79542.1 - 0.018 14.5 0.0 0.041 13.4 0.0 1.6 1 0 0 1 1 1 0 Putative methyltransferase FtsJ PF01728.19 EXF79542.1 - 0.034 14.2 0.0 0.065 13.3 0.0 1.4 1 0 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_23 PF13489.6 EXF79543.1 - 1.4e-24 86.8 0.0 2e-24 86.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF79543.1 - 9.1e-10 38.5 0.0 6.5e-09 35.8 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF79543.1 - 1.5e-09 38.4 0.0 3.1e-09 37.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF79543.1 - 1.5e-06 28.7 0.0 3e-06 27.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF79543.1 - 0.00011 22.8 0.0 0.00074 20.2 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.19 EXF79543.1 - 0.0023 18.1 0.0 0.0066 16.6 0.0 1.7 2 0 0 2 2 2 1 FtsJ-like methyltransferase Methyltransf_4 PF02390.17 EXF79543.1 - 0.0081 15.6 0.0 0.018 14.5 0.0 1.5 1 0 0 1 1 1 1 Putative methyltransferase MTS PF05175.14 EXF79543.1 - 0.0091 15.6 0.0 0.015 14.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Ubie_methyltran PF01209.18 EXF79543.1 - 0.01 15.2 0.0 0.088 12.1 0.0 2.4 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family PrmA PF06325.13 EXF79543.1 - 0.013 14.9 0.0 0.02 14.3 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Ferritin_2 PF13668.6 EXF79546.1 - 4.9e-16 59.2 1.5 1.6e-15 57.5 0.2 2.0 2 0 0 2 2 2 1 Ferritin-like domain p450 PF00067.22 EXF79547.1 - 5.2e-55 187.0 0.0 6.3e-55 186.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 APH PF01636.23 EXF79549.1 - 4.4e-14 53.0 0.0 1.6e-13 51.2 0.0 1.8 1 1 1 2 2 2 1 Phosphotransferase enzyme family EcKinase PF02958.20 EXF79549.1 - 0.17 11.2 0.0 0.26 10.6 0.0 1.2 1 0 0 1 1 1 0 Ecdysteroid kinase Glyco_trans_1_4 PF13692.6 EXF79550.1 - 1.8e-07 31.6 0.0 7e-07 29.7 0.0 1.9 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glycos_transf_1 PF00534.20 EXF79550.1 - 5.7e-06 26.0 0.0 1.1e-05 25.0 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 EXF79550.1 - 0.0013 19.1 0.0 0.0027 18.1 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Cation_efflux PF01545.21 EXF79551.1 - 3.8e-47 160.6 4.4 5.2e-47 160.2 4.4 1.2 1 0 0 1 1 1 1 Cation efflux family Mito_carr PF00153.27 EXF79552.1 - 6.7e-55 183.0 3.5 2.5e-18 65.8 0.1 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein His_Phos_1 PF00300.22 EXF79553.1 - 4.8e-07 29.7 1.5 0.16 11.7 0.0 3.9 3 1 1 4 4 4 3 Histidine phosphatase superfamily (branch 1) Methyltransf_25 PF13649.6 EXF79554.1 - 8.2e-22 77.7 0.0 1.8e-21 76.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF79554.1 - 6.9e-18 65.1 0.0 1.4e-17 64.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF79554.1 - 3.2e-14 53.0 0.0 5.7e-14 52.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF79554.1 - 1e-13 51.8 0.0 2.6e-13 50.5 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EXF79554.1 - 1.2e-10 41.5 0.0 2e-10 40.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EXF79554.1 - 4.9e-10 39.1 0.0 6.5e-10 38.7 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 EXF79554.1 - 4.1e-08 33.0 0.0 8.2e-08 32.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_PK PF05891.12 EXF79554.1 - 2e-07 30.7 0.0 4.6e-07 29.6 0.0 1.4 1 1 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_2 PF00891.18 EXF79554.1 - 8.6e-07 28.5 0.0 1.5e-06 27.7 0.0 1.3 1 1 0 1 1 1 1 O-methyltransferase domain CMAS PF02353.20 EXF79554.1 - 9.3e-06 25.1 0.0 1.2e-05 24.8 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase CheR PF01739.18 EXF79554.1 - 2.1e-05 24.1 0.0 0.00074 19.1 0.0 2.3 1 1 1 2 2 2 1 CheR methyltransferase, SAM binding domain NodS PF05401.11 EXF79554.1 - 0.00017 21.3 0.0 0.00022 20.9 0.0 1.2 1 0 0 1 1 1 1 Nodulation protein S (NodS) TehB PF03848.14 EXF79554.1 - 0.001 18.5 0.0 0.0015 18.0 0.0 1.2 1 0 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_16 PF10294.9 EXF79554.1 - 0.0013 18.5 0.0 0.0021 17.8 0.0 1.3 1 0 0 1 1 1 1 Lysine methyltransferase PCMT PF01135.19 EXF79554.1 - 0.0052 16.6 0.0 0.0075 16.0 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DUF2608 PF11019.8 EXF79554.1 - 0.011 15.3 0.0 0.027 14.0 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2608) UPF0020 PF01170.18 EXF79554.1 - 0.028 14.1 0.0 0.13 11.9 0.0 1.9 2 0 0 2 2 2 0 Putative RNA methylase family UPF0020 Methyltransf_4 PF02390.17 EXF79554.1 - 0.038 13.5 0.0 0.1 12.1 0.0 1.7 1 1 0 1 1 1 0 Putative methyltransferase Peptidase_C13 PF01650.18 EXF79555.1 - 7.7e-41 140.3 0.3 1e-40 139.9 0.3 1.1 1 0 0 1 1 1 1 Peptidase C13 family TFIIIC_delta PF12657.7 EXF79556.1 - 1.1e-16 61.3 0.0 6.3e-16 58.8 0.0 2.2 2 0 0 2 2 2 1 Transcription factor IIIC subunit delta N-term zf-TFIIIC PF12660.7 EXF79556.1 - 1.9e-10 40.6 2.9 1.3e-09 37.9 2.7 2.3 3 0 0 3 3 3 1 Putative zinc-finger of transcription factor IIIC complex CVNH PF08881.10 EXF79557.1 - 0.0005 20.7 0.2 0.0011 19.6 0.1 1.6 1 1 1 2 2 2 1 CVNH domain Glyco_hyd_65N_2 PF14498.6 EXF79558.1 - 3.6e-49 167.8 0.1 6.3e-49 167.0 0.1 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, N-terminal domain FAD_binding_4 PF01565.23 EXF79558.1 - 3.6e-31 107.7 6.2 3.6e-31 107.7 6.2 2.5 3 0 0 3 3 3 1 FAD binding domain BBE PF08031.12 EXF79558.1 - 6.6e-07 29.3 0.1 1.5e-06 28.2 0.1 1.6 1 0 0 1 1 1 1 Berberine and berberine like Na_Ca_ex PF01699.24 EXF79559.1 - 6.7e-44 149.5 34.6 1.2e-23 83.7 13.9 2.2 2 0 0 2 2 2 2 Sodium/calcium exchanger protein IML1 PF12257.8 EXF79560.1 - 2.1e-120 401.2 0.0 2.9e-120 400.7 0.0 1.2 1 0 0 1 1 1 1 Vacuolar membrane-associated protein Iml1 DEP PF00610.21 EXF79560.1 - 9.7e-26 89.6 0.2 2e-25 88.6 0.2 1.6 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Cation_efflux PF01545.21 EXF79561.1 - 7e-47 159.7 0.0 1e-46 159.2 0.0 1.2 1 0 0 1 1 1 1 Cation efflux family DUF1774 PF08611.10 EXF79561.1 - 0.053 13.8 1.3 0.15 12.4 0.0 2.4 3 1 0 3 3 3 0 Fungal protein of unknown function (DUF1774) Oxidored_q2 PF00420.24 EXF79561.1 - 0.46 10.1 3.5 1.4 8.6 0.5 2.8 2 1 1 3 3 3 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L Transport_MerF PF11431.8 EXF79561.1 - 1.9 8.5 5.0 4.8 7.2 1.1 2.8 2 0 0 2 2 2 0 Membrane transport protein MerF FNIP_N PF14636.6 EXF79562.1 - 2.4e-40 139.0 0.2 2.4e-40 139.0 0.2 4.3 4 2 0 4 4 4 1 Folliculin-interacting protein N-terminus FNIP_M PF14637.6 EXF79562.1 - 0.056 13.4 0.1 0.35 10.9 0.0 2.0 1 1 1 2 2 2 0 Folliculin-interacting protein middle domain Baculo_PP31 PF05311.11 EXF79562.1 - 0.12 11.9 0.2 0.21 11.0 0.2 1.4 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) Nipped-B_C PF12830.7 EXF79563.1 - 3e-51 174.1 1.6 3e-51 174.1 1.6 2.6 3 0 0 3 3 3 1 Sister chromatid cohesion C-terminus Cohesin_HEAT PF12765.7 EXF79563.1 - 1.6e-07 31.5 1.1 8.3e-07 29.2 0.3 2.6 2 0 0 2 2 2 1 HEAT repeat associated with sister chromatid cohesion Adaptin_N PF01602.20 EXF79563.1 - 4.2e-07 28.9 0.2 9.6e-06 24.4 0.0 2.8 3 0 0 3 3 3 1 Adaptin N terminal region HEAT PF02985.22 EXF79563.1 - 6.4e-05 22.9 0.8 0.51 10.7 0.0 4.3 4 0 0 4 4 4 2 HEAT repeat Cnd1 PF12717.7 EXF79563.1 - 0.0019 18.3 0.1 0.049 13.7 0.0 2.6 1 1 1 2 2 2 1 non-SMC mitotic condensation complex subunit 1 NT5C PF06941.12 EXF79563.1 - 0.089 12.7 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) WbqC PF08889.11 EXF79563.1 - 0.29 11.0 0.8 7.1 6.5 0.0 2.9 3 0 0 3 3 3 0 WbqC-like protein family TFIIS_C PF01096.18 EXF79564.1 - 3.6e-14 52.3 1.3 3.6e-14 52.3 1.3 3.3 4 0 0 4 4 4 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.16 EXF79564.1 - 0.00051 19.9 3.8 0.00051 19.9 3.8 2.7 3 0 0 3 3 3 1 RNA polymerases M/15 Kd subunit Zn-ribbon_8 PF09723.10 EXF79564.1 - 0.0039 17.3 4.9 0.49 10.6 0.1 2.6 2 0 0 2 2 2 2 Zinc ribbon domain HypA PF01155.19 EXF79564.1 - 0.0056 16.7 1.4 2.6 8.1 0.0 2.4 2 0 0 2 2 2 2 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DZR PF12773.7 EXF79564.1 - 0.006 16.6 4.8 1.2 9.2 2.0 2.5 2 0 0 2 2 2 2 Double zinc ribbon OrfB_Zn_ribbon PF07282.11 EXF79564.1 - 0.0088 15.9 3.4 0.49 10.3 0.2 2.6 2 0 0 2 2 2 2 Putative transposase DNA-binding domain C1_1 PF00130.22 EXF79564.1 - 0.046 13.6 1.0 0.046 13.6 1.0 1.9 2 1 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-ribbon_3 PF13248.6 EXF79564.1 - 0.098 12.1 7.6 0.8 9.2 0.1 3.4 3 0 0 3 3 3 0 zinc-ribbon domain Lar_restr_allev PF14354.6 EXF79564.1 - 0.14 12.5 11.0 0.26 11.7 0.4 3.1 2 1 0 2 2 2 0 Restriction alleviation protein Lar Zn_Tnp_IS1595 PF12760.7 EXF79564.1 - 0.55 10.2 5.1 1.7 8.6 0.7 2.5 2 1 0 2 2 2 0 Transposase zinc-ribbon domain zf-RING_7 PF02591.15 EXF79564.1 - 1.5 9.0 6.8 60 3.9 0.0 3.8 4 0 0 4 4 4 0 C4-type zinc ribbon domain NOB1_Zn_bind PF08772.11 EXF79564.1 - 5.5 7.2 11.4 1.1 9.5 0.3 3.0 2 2 1 3 3 3 0 Nin one binding (NOB1) Zn-ribbon like HEAT_2 PF13646.6 EXF79565.1 - 2.5e-26 91.9 9.1 1.1e-12 48.1 0.1 4.1 2 2 2 4 4 4 2 HEAT repeats HEAT_PBS PF03130.16 EXF79565.1 - 1.6e-18 65.4 5.5 0.0034 17.9 0.0 6.7 6 0 0 6 6 6 5 PBS lyase HEAT-like repeat HEAT PF02985.22 EXF79565.1 - 2.3e-08 33.6 3.0 0.77 10.2 0.0 5.8 6 0 0 6 6 6 3 HEAT repeat HEAT_EZ PF13513.6 EXF79565.1 - 1.9e-06 28.2 8.4 0.62 10.6 0.0 6.0 3 2 2 5 5 5 4 HEAT-like repeat ParA PF10609.9 EXF79566.1 - 1.6e-92 309.4 0.0 1.9e-92 309.2 0.0 1.0 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 EXF79566.1 - 1.1e-08 35.2 0.0 2e-08 34.4 0.0 1.5 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 EXF79566.1 - 0.00032 20.7 0.1 0.0037 17.2 0.1 2.1 1 1 0 1 1 1 1 AAA domain ArsA_ATPase PF02374.15 EXF79566.1 - 0.00046 19.5 0.1 0.0033 16.6 0.1 2.1 2 0 0 2 2 2 1 Anion-transporting ATPase Fer4_NifH PF00142.18 EXF79566.1 - 0.0019 17.7 0.0 1.1 8.6 0.0 2.2 2 0 0 2 2 2 2 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family AAA_25 PF13481.6 EXF79566.1 - 0.0041 16.7 0.1 0.0069 16.0 0.1 1.3 1 0 0 1 1 1 1 AAA domain MipZ PF09140.11 EXF79566.1 - 0.0096 15.2 0.0 0.021 14.1 0.0 1.5 1 1 0 1 1 1 1 ATPase MipZ AAA_30 PF13604.6 EXF79566.1 - 0.012 15.3 0.0 0.02 14.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_26 PF13500.6 EXF79566.1 - 0.014 15.2 0.0 2.4 8.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 EXF79566.1 - 0.023 14.6 0.0 0.047 13.6 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase TsaE PF02367.17 EXF79566.1 - 0.05 13.6 0.0 0.089 12.8 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_16 PF13191.6 EXF79566.1 - 0.066 13.6 0.0 0.11 12.9 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain CLP1_P PF16575.5 EXF79566.1 - 0.078 12.8 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop RNA_helicase PF00910.22 EXF79566.1 - 0.1 13.0 0.0 0.19 12.2 0.0 1.4 1 0 0 1 1 1 0 RNA helicase Zn_Tnp_IS1595 PF12760.7 EXF79566.1 - 0.11 12.5 0.0 0.32 11.0 0.0 1.7 1 0 0 1 1 1 0 Transposase zinc-ribbon domain VirE PF05272.11 EXF79566.1 - 0.13 12.0 0.0 0.45 10.2 0.0 1.8 2 0 0 2 2 2 0 Virulence-associated protein E Cofilin_ADF PF00241.20 EXF79567.1 - 2.5e-19 69.3 0.1 3e-19 69.0 0.1 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein MoCF_biosynth PF00994.24 EXF79568.1 - 3e-35 121.0 0.0 4.6e-35 120.4 0.0 1.3 1 0 0 1 1 1 1 Probable molybdopterin binding domain Ras PF00071.22 EXF79570.1 - 1.5e-59 200.3 0.2 1.7e-59 200.0 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EXF79570.1 - 1.8e-20 73.4 0.0 2.7e-20 72.8 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EXF79570.1 - 3.1e-08 33.3 0.0 3.4e-08 33.1 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EXF79570.1 - 6.9e-06 25.7 0.1 4.3e-05 23.2 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EXF79570.1 - 0.00015 21.7 0.3 0.58 10.0 0.0 2.4 1 1 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EXF79570.1 - 0.0017 18.4 0.0 0.0026 17.8 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase MMR_HSR1_Xtn PF16897.5 EXF79570.1 - 0.0049 16.9 0.0 0.0094 16.0 0.0 1.5 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain FeoB_N PF02421.18 EXF79570.1 - 0.005 16.4 0.0 0.0093 15.5 0.0 1.5 1 1 0 1 1 1 1 Ferrous iron transport protein B ATP_bind_1 PF03029.17 EXF79570.1 - 0.15 11.8 1.3 2.1 8.0 0.0 2.1 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein zf-C2H2_11 PF16622.5 EXF79572.1 - 0.0019 17.9 0.7 0.005 16.6 0.7 1.8 1 0 0 1 1 1 1 zinc-finger C2H2-type Nbl1_Borealin_N PF10444.9 EXF79572.1 - 0.013 15.1 1.0 2.7 7.7 0.2 2.6 2 0 0 2 2 2 0 Nbl1 / Borealin N terminal zf-C2H2_4 PF13894.6 EXF79572.1 - 0.014 16.2 4.3 0.36 11.8 0.2 3.4 2 0 0 2 2 2 0 C2H2-type zinc finger LMBR1 PF04791.16 EXF79572.1 - 0.054 12.4 0.4 0.077 11.9 0.4 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein zf-C2H2_jaz PF12171.8 EXF79572.1 - 0.055 13.8 1.8 3.5 8.0 0.0 3.3 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding Mod_r PF07200.13 EXF79572.1 - 0.21 11.7 3.6 0.66 10.1 1.4 2.7 3 0 0 3 3 3 0 Modifier of rudimentary (Mod(r)) protein Helo_like_N PF17111.5 EXF79572.1 - 0.38 10.1 9.8 0.13 11.6 1.4 3.2 2 1 1 3 3 3 0 Fungal N-terminal domain of STAND proteins KASH_CCD PF14662.6 EXF79572.1 - 0.68 9.7 5.1 7 6.4 0.2 2.3 2 0 0 2 2 2 0 Coiled-coil region of CCDC155 or KASH Lebercilin PF15619.6 EXF79572.1 - 1.8 8.2 8.6 0.42 10.2 3.3 2.2 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease zf-C2H2 PF00096.26 EXF79572.1 - 5.4 7.7 6.6 8.2 7.1 0.1 3.4 3 0 0 3 3 3 0 Zinc finger, C2H2 type Helo_like_N PF17111.5 EXF79573.1 - 3.6e-05 23.2 0.2 5.5e-05 22.6 0.2 1.3 1 0 0 1 1 1 1 Fungal N-terminal domain of STAND proteins Jnk-SapK_ap_N PF09744.9 EXF79573.1 - 0.025 14.8 0.0 0.029 14.6 0.0 1.2 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 LMBR1 PF04791.16 EXF79573.1 - 0.061 12.2 0.2 0.07 12.0 0.2 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Kelch_5 PF13854.6 EXF79577.1 - 2.6e-12 46.4 7.1 2.9e-12 46.3 0.6 3.7 4 0 0 4 4 4 1 Kelch motif Kelch_3 PF13415.6 EXF79577.1 - 0.00011 22.3 0.1 0.0016 18.7 0.1 3.1 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_6 PF13964.6 EXF79577.1 - 0.0016 18.6 1.8 0.25 11.7 0.2 3.8 3 0 0 3 3 3 1 Kelch motif stn_TNFRSF12A PF12191.8 EXF79577.1 - 0.009 16.2 0.4 0.021 15.0 0.4 1.5 1 0 0 1 1 1 1 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain Kelch_1 PF01344.25 EXF79577.1 - 0.033 13.8 5.3 0.28 10.8 0.4 3.7 3 1 0 3 3 3 0 Kelch motif Kelch_2 PF07646.15 EXF79577.1 - 0.31 11.1 3.6 6.5 6.9 0.5 3.6 4 0 0 4 4 4 0 Kelch motif PTP_tm PF18861.1 EXF79577.1 - 0.74 9.8 2.3 1.8 8.5 1.7 1.9 2 0 0 2 2 2 0 Transmembrane domain of protein tyrosine phosphatase, receptor type J Kelch_4 PF13418.6 EXF79577.1 - 5.8 7.0 11.6 0.84 9.7 0.1 4.3 6 0 0 6 6 6 0 Galactose oxidase, central domain DUF2207 PF09972.9 EXF79578.1 - 2.6 6.7 5.4 1.5 7.5 3.1 2.0 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) Spo7 PF03907.13 EXF79580.1 - 6e-95 316.9 0.1 1.1e-94 316.1 0.1 1.4 1 0 0 1 1 1 1 Spo7-like protein Abhydrolase_1 PF00561.20 EXF79581.1 - 5.9e-23 81.8 0.0 3.6e-20 72.7 0.0 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EXF79581.1 - 1.2e-15 57.4 0.0 3.4e-14 52.7 0.0 2.3 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EXF79581.1 - 7.2e-15 56.2 0.0 2.8e-14 54.3 0.0 2.0 2 1 0 2 2 2 1 Alpha/beta hydrolase family DUF915 PF06028.11 EXF79581.1 - 8.6e-07 28.5 0.0 1.7e-06 27.6 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF915) Esterase PF00756.20 EXF79581.1 - 2.9e-05 23.8 0.0 8e-05 22.4 0.0 1.8 2 0 0 2 2 2 1 Putative esterase Abhydrolase_3 PF07859.13 EXF79581.1 - 0.016 15.1 0.0 0.68 9.8 0.0 2.3 2 0 0 2 2 2 0 alpha/beta hydrolase fold Peptidase_S15 PF02129.18 EXF79581.1 - 0.018 14.6 0.0 27 4.2 0.0 3.0 3 0 0 3 3 3 0 X-Pro dipeptidyl-peptidase (S15 family) Ser_hydrolase PF06821.13 EXF79581.1 - 0.028 14.3 0.0 0.058 13.3 0.0 1.5 1 0 0 1 1 1 0 Serine hydrolase Chlorophyllase2 PF12740.7 EXF79581.1 - 0.036 13.0 0.0 0.062 12.2 0.0 1.3 1 0 0 1 1 1 0 Chlorophyllase enzyme LIDHydrolase PF10230.9 EXF79581.1 - 0.042 13.4 0.0 0.12 11.9 0.0 1.7 2 1 1 3 3 3 0 Lipid-droplet associated hydrolase Lipase_3 PF01764.25 EXF79581.1 - 0.056 13.3 0.0 0.099 12.5 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) Abhydrolase_5 PF12695.7 EXF79581.1 - 0.062 13.1 0.0 0.22 11.3 0.0 1.8 2 0 0 2 2 2 0 Alpha/beta hydrolase family Chlorophyllase PF07224.11 EXF79581.1 - 0.12 11.4 0.0 0.18 10.8 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase MARVEL PF01284.23 EXF79583.1 - 7.2e-06 26.1 15.9 1.1e-05 25.4 15.9 1.3 1 0 0 1 1 1 1 Membrane-associating domain Glyco_transf_90 PF05686.12 EXF79584.1 - 2.5e-17 62.9 7.1 3.2e-15 55.9 4.6 2.5 2 1 0 2 2 2 2 Glycosyl transferase family 90 Metal_resist PF13801.6 EXF79584.1 - 0.57 10.4 2.7 11 6.2 0.1 2.8 3 0 0 3 3 3 0 Heavy-metal resistance Nucleoside_tran PF01733.18 EXF79586.1 - 2.3e-37 129.0 5.2 2.3e-37 129.0 5.2 2.0 2 0 0 2 2 2 1 Nucleoside transporter MFS_1 PF07690.16 EXF79586.1 - 0.00083 18.4 5.8 0.00083 18.4 5.8 3.1 1 1 1 2 2 2 1 Major Facilitator Superfamily Ins_P5_2-kin PF06090.12 EXF79587.1 - 5.9e-47 160.7 0.3 8.5e-47 160.2 0.3 1.2 1 0 0 1 1 1 1 Inositol-pentakisphosphate 2-kinase YEATS PF03366.16 EXF79591.1 - 1.5e-29 101.8 0.2 2.6e-29 101.0 0.2 1.4 1 0 0 1 1 1 1 YEATS family DarA_C PF18789.1 EXF79591.1 - 0.018 15.4 0.1 0.055 13.8 0.0 1.9 2 0 0 2 2 2 0 Defence against restriction A C-terminal DUF3160 PF11369.8 EXF79591.1 - 3 6.2 7.3 4.2 5.7 7.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3160) NAD_binding_10 PF13460.6 EXF79592.1 - 5.8e-06 26.3 0.0 0.00035 20.5 0.0 2.8 2 1 0 2 2 2 1 NAD(P)H-binding Epimerase PF01370.21 EXF79592.1 - 2.4e-05 23.9 0.0 5.7e-05 22.7 0.0 1.6 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EXF79592.1 - 0.0052 15.8 0.0 0.025 13.6 0.0 1.9 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 EXF79592.1 - 0.11 11.7 0.0 1.2 8.3 0.0 2.5 2 1 0 2 2 2 0 Male sterility protein GDP_Man_Dehyd PF16363.5 EXF79592.1 - 0.22 10.9 0.0 0.28 10.5 0.0 1.1 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase SYF2 PF08231.12 EXF79593.1 - 1.3e-55 188.2 15.3 1.3e-55 188.2 15.3 1.9 2 0 0 2 2 2 1 SYF2 splicing factor Adenylsucc_synt PF00709.21 EXF79593.1 - 0.18 10.7 1.8 0.37 9.7 0.2 2.0 1 1 1 2 2 2 0 Adenylosuccinate synthetase Bravo_FIGEY PF13882.6 EXF79593.1 - 9.1 7.7 18.0 1.1 10.7 2.8 3.6 2 2 2 4 4 4 0 Bravo-like intracellular region Erythro-docking PF09277.11 EXF79594.1 - 0.073 13.0 0.1 0.22 11.5 0.1 1.8 1 0 0 1 1 1 0 Erythronolide synthase, docking Kelch_5 PF13854.6 EXF79595.1 - 4.9e-13 48.7 14.3 7.7e-09 35.4 0.5 5.5 5 0 0 5 5 5 3 Kelch motif Kelch_4 PF13418.6 EXF79595.1 - 2.1e-09 37.2 12.8 0.00021 21.2 0.3 5.5 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_1 PF01344.25 EXF79595.1 - 1.7e-05 24.3 0.7 0.72 9.5 0.0 4.0 3 1 0 3 3 3 2 Kelch motif Kelch_6 PF13964.6 EXF79595.1 - 3.4e-05 24.0 23.0 0.53 10.7 0.1 5.4 5 1 1 6 6 6 4 Kelch motif Podoplanin PF05808.11 EXF79595.1 - 0.04 14.0 0.1 0.073 13.2 0.1 1.4 1 0 0 1 1 1 0 Podoplanin SKG6 PF08693.10 EXF79595.1 - 0.042 13.3 2.1 0.081 12.4 2.1 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Kelch_2 PF07646.15 EXF79595.1 - 0.18 11.8 13.4 0.97 9.5 0.0 5.9 7 0 0 7 7 7 0 Kelch motif VSP PF03302.13 EXF79595.1 - 0.2 10.5 1.3 0.29 10.0 1.3 1.1 1 0 0 1 1 1 0 Giardia variant-specific surface protein Glyco_hydro_16 PF00722.21 EXF79596.1 - 2.2e-11 43.5 1.5 3.1e-11 43.0 1.5 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 Ecl1 PF12855.7 EXF79597.1 - 3.6e-39 135.7 19.3 3.6e-39 135.7 19.3 1.8 2 0 0 2 2 2 1 ECL1/2/3 zinc binding proteins zf-FLZ PF04570.14 EXF79597.1 - 0.0022 17.4 2.3 0.0047 16.4 2.3 1.5 1 0 0 1 1 1 1 zinc-finger of the FCS-type, C2-C2 PLATZ PF04640.14 EXF79597.1 - 0.024 15.3 1.9 0.042 14.5 1.9 1.3 1 0 0 1 1 1 0 PLATZ transcription factor zf-MYND PF01753.18 EXF79597.1 - 0.15 12.2 1.8 0.27 11.4 1.8 1.4 1 0 0 1 1 1 0 MYND finger DUF2256 PF10013.9 EXF79597.1 - 4.4 7.5 7.1 57 3.9 7.1 2.3 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2256) DUF3176 PF11374.8 EXF79598.1 - 3.4e-29 101.2 0.6 3.4e-29 101.2 0.6 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF3176) Haspin_kinase PF12330.8 EXF79599.1 - 1.7e-35 122.7 0.0 2.4e-35 122.2 0.0 1.1 1 0 0 1 1 1 1 Haspin like kinase domain DUF1682 PF07946.14 EXF79600.1 - 5.6e-115 384.0 1.8 6.5e-115 383.8 1.8 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1682) Big_3 PF07523.12 EXF79600.1 - 0.15 12.4 0.1 9.6 6.6 0.1 2.4 2 0 0 2 2 2 0 Bacterial Ig-like domain (group 3) DUF2140 PF09911.9 EXF79600.1 - 0.31 10.6 0.0 0.31 10.6 0.0 1.9 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2140) DUF4407 PF14362.6 EXF79600.1 - 1.8 7.9 8.1 2.6 7.3 8.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Glyco_hydro_3_C PF01915.22 EXF79601.1 - 1.6e-64 217.7 0.0 2.6e-64 216.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 EXF79601.1 - 1e-37 130.2 0.0 1.6e-37 129.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 EXF79601.1 - 2.5e-24 85.2 0.9 6.2e-24 83.9 0.4 2.0 2 0 0 2 2 2 1 Fibronectin type III-like domain PA14 PF07691.12 EXF79601.1 - 1.1e-18 67.5 0.0 2e-18 66.6 0.0 1.5 1 0 0 1 1 1 1 PA14 domain Lipase_GDSL_2 PF13472.6 EXF79601.1 - 0.056 13.8 0.0 0.14 12.6 0.0 1.6 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family Ig_GlcNase PF18368.1 EXF79601.1 - 0.17 12.0 0.1 0.63 10.2 0.1 1.9 1 1 0 1 1 1 0 Exo-beta-D-glucosaminidase Ig-fold domain DUF2306 PF10067.9 EXF79602.1 - 2.2e-14 53.9 10.1 2.2e-14 53.9 10.1 2.0 2 0 0 2 2 2 1 Predicted membrane protein (DUF2306) DUF420 PF04238.12 EXF79602.1 - 0.027 14.7 2.6 0.027 14.7 2.6 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF420) S1FA PF04689.13 EXF79602.1 - 3.2 7.9 7.3 18 5.5 3.2 3.3 2 1 1 3 3 3 0 DNA binding protein S1FA FTA4 PF13093.6 EXF79603.1 - 3.2e-62 210.0 2.2 3.7e-62 209.8 2.2 1.0 1 0 0 1 1 1 1 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 Peptidase_C2 PF00648.21 EXF79604.1 - 7.2e-63 212.4 1.3 1.2e-61 208.3 1.3 2.2 1 1 0 1 1 1 1 Calpain family cysteine protease tRNA-synt_1c PF00749.21 EXF79604.1 - 0.94 8.3 8.5 1.6 7.5 8.5 1.3 1 0 0 1 1 1 0 tRNA synthetases class I (E and Q), catalytic domain DUF724 PF05266.14 EXF79604.1 - 1.2 9.0 11.4 2.6 7.8 11.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF724) zf-CCHC PF00098.23 EXF79605.1 - 2.8e-45 150.4 60.8 5.8e-08 32.5 2.5 7.2 7 0 0 7 7 7 7 Zinc knuckle zf-CCHC_4 PF14392.6 EXF79605.1 - 5.3e-10 38.9 39.0 0.16 11.7 1.1 7.1 7 0 0 7 7 7 6 Zinc knuckle zf-CCHC_3 PF13917.6 EXF79605.1 - 1.8e-05 24.6 42.7 0.028 14.4 0.1 6.9 4 2 1 5 5 5 3 Zinc knuckle zf-CCHC_5 PF14787.6 EXF79605.1 - 4.1e-05 23.2 43.2 0.0068 16.1 1.0 7.1 4 2 3 7 7 7 5 GAG-polyprotein viral zinc-finger zf-CCHC_2 PF13696.6 EXF79605.1 - 0.059 13.2 2.0 0.059 13.2 2.0 7.2 7 0 0 7 7 7 0 Zinc knuckle zf-CCHC_6 PF15288.6 EXF79605.1 - 0.085 12.7 0.2 0.085 12.7 0.2 6.9 6 1 1 7 7 7 0 Zinc knuckle Nop PF01798.18 EXF79606.1 - 8.8e-72 241.3 0.0 1.3e-71 240.7 0.0 1.3 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin Prp31_C PF09785.9 EXF79606.1 - 1.7e-46 158.1 3.4 2.9e-46 157.3 2.4 1.9 2 0 0 2 2 2 1 Prp31 C terminal domain HAT PF02184.16 EXF79607.1 - 2.7e-23 81.6 72.5 3.6e-12 46.0 2.9 12.9 15 0 0 15 15 14 4 HAT (Half-A-TPR) repeat TPR_14 PF13428.6 EXF79607.1 - 3.8e-20 70.9 27.1 0.0003 21.4 0.1 10.4 9 2 3 12 12 11 6 Tetratricopeptide repeat TPR_19 PF14559.6 EXF79607.1 - 1.8e-17 63.6 2.6 4.1e-05 24.0 0.0 6.4 6 1 2 8 8 7 2 Tetratricopeptide repeat Suf PF05843.14 EXF79607.1 - 2.8e-17 63.7 21.4 3.3e-06 27.3 0.1 6.4 3 1 4 7 7 7 4 Suppressor of forked protein (Suf) TPR_8 PF13181.6 EXF79607.1 - 1.2e-06 28.2 3.1 0.33 11.3 0.0 6.6 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_15 PF13429.6 EXF79607.1 - 5.2e-06 25.9 12.5 1.2 8.3 0.2 6.0 2 1 4 6 6 6 3 Tetratricopeptide repeat TPR_2 PF07719.17 EXF79607.1 - 1.7e-05 24.5 16.2 0.25 11.6 0.1 7.6 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_16 PF13432.6 EXF79607.1 - 0.00044 20.8 15.3 0.66 10.7 0.0 7.2 10 0 0 10 10 8 1 Tetratricopeptide repeat U3_assoc_6 PF08640.11 EXF79607.1 - 0.0018 18.3 28.7 0.052 13.6 0.6 7.7 6 2 2 8 8 8 2 U3 small nucleolar RNA-associated protein 6 TPR_17 PF13431.6 EXF79607.1 - 0.0018 18.5 11.7 3.1 8.4 0.0 7.3 8 0 0 8 8 7 1 Tetratricopeptide repeat BSD PF03909.17 EXF79607.1 - 0.0074 16.3 0.7 0.047 13.7 0.2 2.7 2 1 0 2 2 2 1 BSD domain TPR_9 PF13371.6 EXF79607.1 - 0.019 15.1 9.0 0.85 9.8 0.0 5.0 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_6 PF13174.6 EXF79607.1 - 0.023 15.3 25.6 1.6 9.6 0.0 8.6 10 0 0 10 10 8 0 Tetratricopeptide repeat Tnp_22_trimer PF17489.2 EXF79607.1 - 0.023 14.7 0.1 0.065 13.2 0.1 1.8 1 0 0 1 1 1 0 L1 transposable element trimerization domain NRDE-2 PF08424.10 EXF79607.1 - 0.035 13.3 25.3 0.64 9.1 2.6 5.5 4 3 2 6 6 6 0 NRDE-2, necessary for RNA interference TPR_1 PF00515.28 EXF79607.1 - 0.047 13.5 2.8 26 4.8 0.0 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat c-SKI_SMAD_bind PF08782.10 EXF79607.1 - 0.11 12.7 3.3 2.2 8.5 0.1 3.9 3 0 0 3 3 3 0 c-SKI Smad4 binding domain Fis1_TPR_C PF14853.6 EXF79607.1 - 0.25 11.5 8.3 12 6.0 0.3 5.4 6 0 0 6 6 5 0 Fis1 C-terminal tetratricopeptide repeat TPR_12 PF13424.6 EXF79607.1 - 0.58 10.5 19.0 3.1 8.1 0.0 7.3 10 0 0 10 10 7 0 Tetratricopeptide repeat ER PF01133.17 EXF79607.1 - 0.6 10.2 4.4 37 4.4 0.0 3.8 3 1 1 4 4 4 0 Enhancer of rudimentary La PF05383.17 EXF79610.1 - 1e-16 60.7 0.0 2e-16 59.8 0.0 1.5 1 0 0 1 1 1 1 La domain Got1 PF04178.12 EXF79611.1 - 1.9e-34 118.5 15.2 2.7e-34 118.0 15.2 1.2 1 0 0 1 1 1 1 Got1/Sft2-like family HLH PF00010.26 EXF79612.1 - 2e-12 46.8 0.0 8.4e-12 44.9 0.0 2.0 1 1 0 1 1 1 1 Helix-loop-helix DNA-binding domain DUF1722 PF08349.11 EXF79612.1 - 0.15 12.3 0.0 0.38 11.0 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1722) NPR3 PF03666.13 EXF79613.1 - 7.4e-145 483.3 0.4 1e-144 482.9 0.4 1.2 1 0 0 1 1 1 1 Nitrogen Permease regulator of amino acid transport activity 3 DUF913 PF06025.12 EXF79613.1 - 0.091 11.7 0.9 0.16 10.9 0.9 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Herpes_capsid PF06112.11 EXF79613.1 - 0.096 12.8 3.6 0.21 11.6 3.6 1.5 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein ATHILA PF03078.15 EXF79613.1 - 1.4 7.7 7.8 2.5 6.8 7.8 1.3 1 0 0 1 1 1 0 ATHILA ORF-1 family ERp29 PF07749.12 EXF79613.1 - 1.9 9.4 5.4 2.5 9.1 0.2 2.7 2 0 0 2 2 2 0 Endoplasmic reticulum protein ERp29, C-terminal domain Choline_kinase PF01633.20 EXF79614.1 - 9.4e-53 178.9 0.0 7e-52 176.1 0.0 2.0 2 0 0 2 2 2 1 Choline/ethanolamine kinase APH PF01636.23 EXF79614.1 - 7.6e-12 45.7 0.3 3e-11 43.7 0.0 2.0 2 1 0 2 2 2 1 Phosphotransferase enzyme family EcKinase PF02958.20 EXF79614.1 - 0.0047 16.3 0.0 0.0079 15.5 0.0 1.4 1 0 0 1 1 1 1 Ecdysteroid kinase DUF2451 PF10474.9 EXF79614.1 - 0.083 12.7 0.1 2.5 7.8 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function C-terminus (DUF2451) zf-C2H2 PF00096.26 EXF79616.1 - 4.1 8.1 25.2 1.2 9.7 0.5 6.1 6 0 0 6 6 6 0 Zinc finger, C2H2 type Methyltransf_11 PF08241.12 EXF79617.1 - 2.5e-13 50.5 0.0 6.8e-13 49.1 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF79617.1 - 8.4e-06 26.4 0.0 2.7e-05 24.8 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EXF79617.1 - 0.0083 16.0 0.0 0.023 14.5 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF79617.1 - 0.023 15.4 0.0 0.064 14.0 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain Ubie_methyltran PF01209.18 EXF79617.1 - 0.059 12.7 0.0 0.1 11.9 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.6 EXF79617.1 - 0.079 12.8 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_8 PF05148.15 EXF79617.1 - 0.089 12.6 0.0 0.18 11.6 0.0 1.5 1 0 0 1 1 1 0 Hypothetical methyltransferase SUI1 PF01253.22 EXF79619.1 - 8.2e-26 90.4 0.3 8.2e-26 90.4 0.3 1.9 2 0 0 2 2 2 1 Translation initiation factor SUI1 TnpV PF14198.6 EXF79619.1 - 0.053 13.5 0.3 0.096 12.7 0.3 1.4 1 0 0 1 1 1 0 Transposon-encoded protein TnpV Img2 PF05046.14 EXF79619.1 - 0.1 12.9 0.6 0.19 12.0 0.1 1.8 2 1 0 2 2 2 0 Mitochondrial large subunit ribosomal protein (Img2) FKBP_N PF01346.18 EXF79619.1 - 1.1 10.2 9.3 3.4 8.7 9.3 1.9 1 1 0 1 1 1 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase Nbl1_Borealin_N PF10444.9 EXF79620.1 - 1.5e-19 69.4 6.3 2.6e-19 68.6 6.3 1.4 1 0 0 1 1 1 1 Nbl1 / Borealin N terminal VWA_2 PF13519.6 EXF79621.1 - 7.8e-27 94.0 0.0 1.7e-26 93.0 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 EXF79621.1 - 5.4e-11 43.0 0.5 7.2e-11 42.6 0.5 1.1 1 0 0 1 1 1 1 von Willebrand factor type A domain Ssl1 PF04056.14 EXF79621.1 - 3.9e-07 30.1 0.0 5.4e-07 29.6 0.0 1.2 1 0 0 1 1 1 1 Ssl1-like UIM PF02809.20 EXF79621.1 - 0.019 14.8 0.8 0.057 13.3 0.8 1.9 1 0 0 1 1 1 0 Ubiquitin interaction motif Sybindin PF04099.12 EXF79622.1 - 1.4e-52 177.4 0.0 1.7e-52 177.1 0.0 1.1 1 0 0 1 1 1 1 Sybindin-like family Sedlin_N PF04628.13 EXF79622.1 - 1.3e-07 31.8 0.1 2e-07 31.2 0.1 1.3 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region RNA_pol_Rpb4 PF03874.16 EXF79623.1 - 6e-26 91.2 5.2 7.5e-26 90.9 5.2 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb4 DUF2312 PF10073.9 EXF79623.1 - 0.05 13.3 0.7 0.44 10.2 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2312) EphA2_TM PF14575.6 EXF79624.1 - 0.018 15.9 0.0 0.29 12.1 0.0 2.3 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Plasmodium_Vir PF05795.11 EXF79624.1 - 0.13 11.6 0.2 0.2 11.1 0.2 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein ComS PF17584.2 EXF79624.1 - 4.8 6.8 6.1 31 4.2 1.6 2.7 2 0 0 2 2 2 0 Bacillus competence protein S CPL PF08144.11 EXF79625.1 - 2.4e-43 147.9 0.2 6.8e-41 140.0 0.0 4.0 4 1 0 4 4 4 1 CPL (NUC119) domain PUF PF00806.19 EXF79625.1 - 0.082 12.6 0.0 3.9 7.4 0.0 3.6 5 0 0 5 5 5 0 Pumilio-family RNA binding repeat CRR7 PF12095.8 EXF79625.1 - 0.17 12.3 2.4 0.46 11.0 0.6 2.7 3 0 0 3 3 3 0 Protein CHLORORESPIRATORY REDUCTION 7 RRN3 PF05327.11 EXF79625.1 - 2.1 6.8 11.1 0.055 12.0 1.5 2.3 2 0 0 2 2 2 0 RNA polymerase I specific transcription initiation factor RRN3 RWD PF05773.22 EXF79626.1 - 5.5e-24 84.7 0.6 1.1e-23 83.8 0.6 1.5 1 0 0 1 1 1 1 RWD domain DFRP_C PF16543.5 EXF79626.1 - 3.2e-06 27.5 7.3 3.2e-06 27.5 7.3 2.4 1 1 1 2 2 2 1 DRG Family Regulatory Proteins, Tma46 MRI PF15325.6 EXF79626.1 - 0.078 14.1 2.3 0.17 13.0 2.3 1.6 1 1 0 1 1 1 0 Modulator of retrovirus infection Folliculin PF11704.8 EXF79626.1 - 0.19 11.6 1.0 0.25 11.2 1.0 1.2 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport UNC-79 PF14776.6 EXF79626.1 - 0.24 10.1 1.6 0.3 9.8 1.6 1.2 1 0 0 1 1 1 0 Cation-channel complex subunit UNC-79 TPR_19 PF14559.6 EXF79627.1 - 7.6e-12 45.6 6.4 0.0015 19.0 0.4 3.8 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 EXF79627.1 - 1.1e-10 40.8 3.9 9.6e-06 25.4 0.0 5.5 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_2 PF07719.17 EXF79627.1 - 4.9e-09 35.6 12.4 3.7e-06 26.6 0.0 5.5 6 1 1 7 7 7 2 Tetratricopeptide repeat TPR_1 PF00515.28 EXF79627.1 - 1.1e-08 34.5 0.4 9.6e-05 22.0 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 EXF79627.1 - 2.4e-08 34.2 8.0 0.00026 21.2 1.2 4.1 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 EXF79627.1 - 6.1e-08 33.2 9.5 0.0072 17.0 0.1 4.8 5 1 0 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.6 EXF79627.1 - 7.6e-06 25.6 0.1 0.014 15.4 0.0 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 EXF79627.1 - 1.2e-05 25.7 11.9 0.1 13.5 0.2 5.5 4 2 1 5 5 5 2 Tetratricopeptide repeat TPR_10 PF13374.6 EXF79627.1 - 0.00015 21.5 6.6 0.027 14.4 0.3 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_MalT PF17874.1 EXF79627.1 - 0.00021 20.8 3.1 0.024 14.0 0.0 2.5 2 1 0 2 2 2 2 MalT-like TPR region ANAPC3 PF12895.7 EXF79627.1 - 0.00071 19.8 0.1 4.1 7.7 0.0 3.4 3 2 0 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 EXF79627.1 - 0.00091 18.9 0.0 0.18 11.5 0.0 3.5 3 0 0 3 3 3 1 TPR repeat TPR_9 PF13371.6 EXF79627.1 - 0.011 15.8 3.3 2.8 8.2 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.6 EXF79627.1 - 0.027 14.8 0.0 90 3.8 0.0 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.6 EXF79627.1 - 0.1 13.3 4.8 9.3 7.1 0.0 4.7 5 0 0 5 5 4 0 Tetratricopeptide repeat BTAD PF03704.17 EXF79627.1 - 0.37 11.2 7.9 0.41 11.1 0.3 3.4 2 1 1 3 3 3 0 Bacterial transcriptional activator domain TRP PF06011.12 EXF79628.1 - 2.6e-37 128.6 25.3 7.9e-36 123.7 25.3 2.2 1 1 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.6 EXF79628.1 - 4.9e-25 88.5 0.0 7.6e-25 87.9 0.0 1.3 1 0 0 1 1 1 1 ML-like domain RFamide_26RFa PF11109.8 EXF79628.1 - 0.036 14.6 0.2 0.095 13.2 0.2 1.6 1 0 0 1 1 1 0 Orexigenic neuropeptide Qrfp/P518 HNF-1A_C PF04813.12 EXF79628.1 - 0.082 13.7 1.4 0.36 11.6 1.4 2.1 1 0 0 1 1 1 0 Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C terminus HATPase_c_3 PF13589.6 EXF79629.1 - 4e-13 49.4 0.1 8.4e-13 48.3 0.1 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 EXF79629.1 - 2.9e-08 34.2 0.1 6.6e-08 33.0 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DNA_mis_repair PF01119.19 EXF79629.1 - 0.0013 18.3 0.0 0.0036 16.9 0.0 1.7 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain DMRL_synthase PF00885.19 EXF79630.1 - 2.8e-57 192.5 0.1 3.4e-57 192.2 0.1 1.1 1 0 0 1 1 1 1 6,7-dimethyl-8-ribityllumazine synthase Cwf_Cwc_15 PF04889.12 EXF79631.1 - 0.21 11.3 21.2 0.3 10.8 15.5 2.4 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein RXT2_N PF08595.11 EXF79631.1 - 0.26 11.3 7.1 2 8.4 4.6 2.5 2 0 0 2 2 2 0 RXT2-like, N-terminal DNA_pol_phi PF04931.13 EXF79631.1 - 1.9 6.5 8.4 3.5 5.6 8.4 1.3 1 0 0 1 1 1 0 DNA polymerase phi Formyl_trans_N PF00551.19 EXF79632.1 - 2.1e-39 135.1 0.0 2.6e-39 134.8 0.0 1.1 1 0 0 1 1 1 1 Formyl transferase Glyco_trans_4_4 PF13579.6 EXF79632.1 - 0.05 14.1 0.0 0.067 13.6 0.0 1.2 1 0 0 1 1 1 0 Glycosyl transferase 4-like domain MannoseP_isomer PF01050.18 EXF79632.1 - 0.071 13.0 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 Mannose-6-phosphate isomerase Cation_efflux PF01545.21 EXF79633.1 - 3.5e-23 82.4 11.5 4.9e-23 81.9 11.5 1.2 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 EXF79633.1 - 4e-08 33.3 0.0 7.9e-08 32.3 0.0 1.4 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter PI3_PI4_kinase PF00454.27 EXF79634.1 - 3.1e-39 135.3 0.1 4.8e-37 128.1 0.1 2.4 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 EXF79634.1 - 8.8e-22 77.4 0.0 2.3e-21 76.0 0.0 1.7 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) Proteasome PF00227.26 EXF79635.1 - 2.6e-28 98.8 0.3 9.7e-28 96.9 0.2 1.9 2 1 0 2 2 2 1 Proteasome subunit YTH PF04146.15 EXF79636.1 - 1.7e-62 210.3 0.0 3.1e-62 209.4 0.0 1.5 1 0 0 1 1 1 1 YT521-B-like domain RRM_1 PF00076.22 EXF79636.1 - 0.0056 16.5 0.0 0.015 15.1 0.0 1.8 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EXF79636.1 - 0.15 11.9 0.0 0.34 10.8 0.0 1.5 1 0 0 1 1 1 0 Occluded RNA-recognition motif HSP20 PF00011.21 EXF79637.1 - 2.5e-15 56.5 0.0 1.9e-10 40.8 0.0 2.2 2 0 0 2 2 2 2 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 EXF79637.1 - 6.3e-06 25.6 0.0 0.0085 15.6 0.0 2.3 2 0 0 2 2 2 2 HSP20-like domain found in ArsA SOG2 PF10428.9 EXF79637.1 - 0.02 14.1 0.5 3.2 6.8 1.8 2.0 2 0 0 2 2 2 0 RAM signalling pathway protein SecG PF03840.14 EXF79637.1 - 0.24 11.5 0.6 0.39 10.8 0.6 1.3 1 0 0 1 1 1 0 Preprotein translocase SecG subunit Pneumo_att_G PF05539.11 EXF79637.1 - 1.4 8.5 6.8 1.8 8.1 6.8 1.1 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G Rad51 PF08423.11 EXF79638.1 - 1.3e-127 424.4 0.0 1.6e-127 424.1 0.0 1.1 1 0 0 1 1 1 1 Rad51 RecA PF00154.21 EXF79638.1 - 5.5e-09 35.9 0.0 7.6e-09 35.4 0.0 1.1 1 0 0 1 1 1 1 recA bacterial DNA recombination protein AAA_25 PF13481.6 EXF79638.1 - 1.7e-08 34.3 0.0 2.6e-08 33.7 0.0 1.2 1 0 0 1 1 1 1 AAA domain HHH_5 PF14520.6 EXF79638.1 - 4e-07 30.6 0.3 4.8e-06 27.1 0.1 2.4 2 0 0 2 2 2 1 Helix-hairpin-helix domain ATPase PF06745.13 EXF79638.1 - 1.1e-05 24.9 0.0 2.4e-05 23.8 0.0 1.6 1 1 0 1 1 1 1 KaiC DnaB_C PF03796.15 EXF79638.1 - 0.033 13.5 0.1 0.16 11.3 0.0 1.9 2 0 0 2 2 2 0 DnaB-like helicase C terminal domain ssDNA_TraI_N PF18272.1 EXF79638.1 - 0.11 12.5 0.1 0.59 10.2 0.1 2.1 2 0 0 2 2 2 0 single-stranded DNA binding TraI N-terminal subdomain AAA_24 PF13479.6 EXF79638.1 - 0.13 11.9 0.0 0.26 11.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain PAXNEB PF05625.11 EXF79638.1 - 0.19 10.8 0.2 0.84 8.7 0.1 1.8 2 0 0 2 2 2 0 PAXNEB protein Nup160 PF11715.8 EXF79639.1 - 9.3e-147 489.9 0.6 1.2e-146 489.6 0.6 1.1 1 0 0 1 1 1 1 Nucleoporin Nup120/160 TPR_2 PF07719.17 EXF79639.1 - 0.85 9.9 2.9 0.69 10.2 0.0 2.5 3 0 0 3 3 3 0 Tetratricopeptide repeat peroxidase PF00141.23 EXF79641.1 - 2.1e-19 70.2 0.4 3.5e-19 69.4 0.4 1.3 1 0 0 1 1 1 1 Peroxidase FAD_binding_3 PF01494.19 EXF79642.1 - 4e-74 250.0 0.0 4.9e-74 249.7 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Phe_hydrox_dim PF07976.12 EXF79642.1 - 1.4e-30 106.5 0.0 2.5e-30 105.7 0.0 1.4 1 0 0 1 1 1 1 Phenol hydroxylase, C-terminal dimerisation domain Pyr_redox_2 PF07992.14 EXF79642.1 - 1.6e-07 30.9 0.0 0.00012 21.5 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EXF79642.1 - 7.2e-05 21.7 0.3 0.00015 20.6 0.2 1.5 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox PF00070.27 EXF79642.1 - 0.00019 21.9 0.0 0.018 15.6 0.0 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EXF79642.1 - 0.00083 18.5 0.1 0.0015 17.7 0.1 1.4 1 0 0 1 1 1 1 Lycopene cyclase protein NAD_binding_8 PF13450.6 EXF79642.1 - 0.0012 19.1 0.1 0.0029 17.8 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EXF79642.1 - 0.0039 16.8 0.1 0.34 10.5 0.0 2.2 1 1 1 2 2 2 1 FAD dependent oxidoreductase Trp_halogenase PF04820.14 EXF79642.1 - 0.0062 15.4 0.0 0.0094 14.8 0.0 1.2 1 0 0 1 1 1 1 Tryptophan halogenase GIDA PF01134.22 EXF79642.1 - 0.0094 15.1 0.0 0.015 14.4 0.0 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A Thi4 PF01946.17 EXF79642.1 - 0.03 13.6 0.0 0.051 12.8 0.0 1.2 1 0 0 1 1 1 0 Thi4 family AlaDh_PNT_C PF01262.21 EXF79642.1 - 0.031 13.6 0.0 0.053 12.8 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox_3 PF13738.6 EXF79642.1 - 0.23 10.7 0.1 0.37 10.0 0.1 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase TPR_12 PF13424.6 EXF79644.1 - 2.5e-23 82.1 4.6 9.8e-20 70.6 2.3 2.9 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 EXF79644.1 - 3.9e-22 77.4 12.3 9.2e-13 47.6 0.8 4.3 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 EXF79644.1 - 9e-14 50.4 10.4 0.00012 21.9 0.3 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 EXF79644.1 - 8.8e-13 47.5 6.7 0.0004 20.1 0.3 4.1 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 EXF79644.1 - 7.9e-07 28.7 12.2 0.0088 16.1 0.4 4.2 4 0 0 4 4 3 3 Tetratricopeptide repeat TPR_14 PF13428.6 EXF79644.1 - 3.1e-06 27.5 0.9 0.11 13.4 0.5 4.2 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 EXF79644.1 - 9.8e-06 25.4 12.5 0.27 11.6 0.1 4.2 4 0 0 4 4 3 3 Tetratricopeptide repeat TPR_19 PF14559.6 EXF79644.1 - 5.9e-05 23.5 1.5 0.34 11.4 0.1 2.9 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_MalT PF17874.1 EXF79644.1 - 7.4e-05 22.3 0.2 0.00019 21.0 0.2 1.6 1 0 0 1 1 1 1 MalT-like TPR region TPR_4 PF07721.14 EXF79644.1 - 0.00086 19.7 0.0 0.13 13.0 0.0 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 EXF79644.1 - 0.00096 19.4 0.2 2.5 8.7 0.0 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 EXF79644.1 - 0.0012 19.4 0.9 0.0053 17.4 0.3 2.5 2 1 0 2 2 1 1 Tetratricopeptide repeat DUF2225 PF09986.9 EXF79644.1 - 0.019 14.7 1.2 0.033 13.9 0.2 2.0 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) zf-C2H2 PF00096.26 EXF79644.1 - 0.041 14.3 0.6 0.041 14.3 0.6 3.3 4 0 0 4 4 2 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EXF79644.1 - 0.072 14.0 0.4 0.072 14.0 0.4 3.7 3 0 0 3 3 3 0 C2H2-type zinc finger TPR_3 PF07720.12 EXF79644.1 - 0.092 12.8 3.1 0.091 12.8 0.5 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat RPN6_N PF18055.1 EXF79644.1 - 1.9 8.9 8.6 0.29 11.5 0.3 3.0 3 0 0 3 3 2 0 26S proteasome regulatory subunit RPN6 N-terminal domain TPR_6 PF13174.6 EXF79644.1 - 2.7 8.8 9.9 9.9 7.0 0.7 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat dsDNA_bind PF01984.20 EXF79644.1 - 4.6 7.6 8.4 1.5 9.1 0.5 3.0 3 0 0 3 3 3 0 Double-stranded DNA-binding domain SOCS_box PF07525.16 EXF79646.1 - 0.084 13.3 0.0 0.15 12.4 0.0 1.4 1 0 0 1 1 1 0 SOCS box FRQ PF09421.10 EXF79647.1 - 0 1401.0 55.0 0 1400.8 55.0 1.0 1 0 0 1 1 1 1 Frequency clock protein ketoacyl-synt PF00109.26 EXF79648.1 - 7.5e-75 251.8 0.0 6.3e-74 248.7 0.0 2.2 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 EXF79648.1 - 1.4e-34 118.6 0.1 3.7e-34 117.3 0.0 1.8 2 0 0 2 2 1 1 Beta-ketoacyl synthase, C-terminal domain HTH_51 PF18558.1 EXF79648.1 - 6.2e-25 86.9 0.0 1.7e-24 85.5 0.0 1.8 1 0 0 1 1 1 1 Helix-turn-helix domain PP-binding PF00550.25 EXF79648.1 - 8.8e-24 83.6 6.5 1.5e-14 54.1 1.1 2.7 2 0 0 2 2 2 2 Phosphopantetheine attachment site PS-DH PF14765.6 EXF79648.1 - 5.1e-22 78.5 0.1 8.6e-22 77.7 0.1 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 EXF79648.1 - 7.5e-20 71.7 0.0 1.4e-19 70.8 0.0 1.3 1 0 0 1 1 1 1 Acyl transferase domain Methyltransf_12 PF08242.12 EXF79648.1 - 4.5e-15 56.2 0.0 1.4e-14 54.6 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Abhydrolase_3 PF07859.13 EXF79648.1 - 4.1e-13 49.7 0.0 3e-11 43.6 0.0 2.5 2 0 0 2 2 2 1 alpha/beta hydrolase fold Methyltransf_25 PF13649.6 EXF79648.1 - 3.9e-10 40.3 0.0 1.8e-09 38.2 0.0 2.3 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EXF79648.1 - 4.5e-10 39.6 0.0 1.3e-09 38.2 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF79648.1 - 9.3e-08 32.6 0.1 4.2e-07 30.5 0.0 2.3 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF79648.1 - 2.2e-07 30.8 0.0 4.8e-07 29.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Peptidase_S9 PF00326.21 EXF79648.1 - 5.3e-06 26.1 0.0 0.017 14.6 0.0 2.5 2 0 0 2 2 2 2 Prolyl oligopeptidase family KAsynt_C_assoc PF16197.5 EXF79648.1 - 8.3e-05 23.0 0.0 0.00026 21.4 0.0 1.9 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Abhydrolase_6 PF12697.7 EXF79648.1 - 9.2e-05 23.1 3.8 9.2e-05 23.1 3.8 3.3 3 0 0 3 3 3 1 Alpha/beta hydrolase family PP-binding_2 PF14573.6 EXF79648.1 - 0.00028 21.0 0.3 0.82 9.9 0.1 2.7 2 0 0 2 2 2 2 Acyl-carrier Thiolase_N PF00108.23 EXF79648.1 - 0.0003 20.2 0.1 0.0043 16.5 0.1 2.2 2 0 0 2 2 2 1 Thiolase, N-terminal domain Thioesterase PF00975.20 EXF79648.1 - 0.029 14.5 0.0 0.63 10.1 0.0 2.4 2 0 0 2 2 2 0 Thioesterase domain Methyltransf_33 PF10017.9 EXF79648.1 - 0.035 13.3 0.0 0.063 12.4 0.0 1.3 1 0 0 1 1 1 0 Histidine-specific methyltransferase, SAM-dependent DLH PF01738.18 EXF79648.1 - 0.036 13.6 0.0 5.3 6.5 0.0 2.4 2 0 0 2 2 2 0 Dienelactone hydrolase family Methyltransf_16 PF10294.9 EXF79648.1 - 0.039 13.7 0.0 0.15 11.8 0.0 1.9 1 1 0 1 1 1 0 Lysine methyltransferase p450 PF00067.22 EXF79649.1 - 8.1e-66 222.6 0.0 9.8e-66 222.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Nodulin PF02451.15 EXF79649.1 - 0.057 12.9 0.0 0.1 12.0 0.0 1.4 1 0 0 1 1 1 0 Nodulin Trp_DMAT PF11991.8 EXF79650.1 - 2.2e-94 316.9 0.0 1.6e-93 314.1 0.0 1.9 2 0 0 2 2 2 1 Tryptophan dimethylallyltransferase Fungal_trans_2 PF11951.8 EXF79651.1 - 2.3e-07 30.0 1.1 1.3e-05 24.2 0.2 2.1 2 0 0 2 2 2 2 Fungal specific transcription factor domain Thx PF17070.5 EXF79651.1 - 0.68 10.1 2.1 1.2 9.3 2.1 1.4 1 0 0 1 1 1 0 30S ribosomal protein Thx FAD_binding_4 PF01565.23 EXF79652.1 - 8.2e-20 71.0 0.3 1.7e-19 70.0 0.3 1.5 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EXF79652.1 - 0.0007 19.7 0.3 0.0018 18.3 0.3 1.8 1 0 0 1 1 1 1 Berberine and berberine like adh_short PF00106.25 EXF79653.1 - 4.4e-17 62.2 0.1 6.3e-17 61.7 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF79653.1 - 1.2e-14 54.4 0.2 1.4e-14 54.2 0.2 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF79653.1 - 1.8e-05 24.8 0.3 2.3e-05 24.4 0.3 1.2 1 0 0 1 1 1 1 KR domain ThiF PF00899.21 EXF79653.1 - 0.00022 20.7 0.1 0.0003 20.2 0.1 1.2 1 0 0 1 1 1 1 ThiF family Ldh_1_N PF00056.23 EXF79653.1 - 0.012 15.7 0.2 0.023 14.8 0.2 1.6 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain RmlD_sub_bind PF04321.17 EXF79653.1 - 0.016 14.3 0.1 0.25 10.4 0.1 2.1 2 0 0 2 2 2 0 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 EXF79653.1 - 0.024 13.8 0.0 0.03 13.4 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Epimerase PF01370.21 EXF79653.1 - 0.16 11.4 0.1 0.21 11.0 0.1 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family adh_short PF00106.25 EXF79654.1 - 2.7e-19 69.4 1.6 3.3e-17 62.6 0.7 2.2 1 1 1 2 2 2 2 short chain dehydrogenase KR PF08659.10 EXF79654.1 - 1.9e-15 57.3 0.1 2.6e-15 56.8 0.1 1.3 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.6 EXF79654.1 - 3e-12 46.6 1.5 1.2e-09 38.1 0.2 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase ATP-grasp_5 PF13549.6 EXF79654.1 - 0.021 14.3 0.0 0.04 13.4 0.0 1.4 1 0 0 1 1 1 0 ATP-grasp domain Myb_DNA-binding PF00249.31 EXF79655.1 - 1.3e-10 41.3 5.3 1.6e-09 37.8 0.1 3.1 3 0 0 3 3 3 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EXF79655.1 - 2.3e-10 40.6 0.9 1.2e-06 28.6 0.1 3.4 3 0 0 3 3 3 2 Myb-like DNA-binding domain Rap1_C PF11626.8 EXF79655.1 - 0.014 15.5 0.0 1.5 9.0 0.0 2.5 2 1 0 2 2 2 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain Myb_DNA-bind_7 PF15963.5 EXF79655.1 - 0.11 12.3 0.1 0.39 10.7 0.0 1.9 2 0 0 2 2 2 0 Myb DNA-binding like AMP-binding PF00501.28 EXF79656.1 - 6e-32 110.8 0.0 1.1e-31 109.9 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme NAD_binding_4 PF07993.12 EXF79656.1 - 6.3e-27 94.4 0.0 9.7e-27 93.7 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein Epimerase PF01370.21 EXF79656.1 - 4.7e-09 36.1 0.0 1.2e-08 34.8 0.0 1.7 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family FB_lectin PF07367.11 EXF79656.1 - 0.0037 17.2 0.0 1.8 8.5 0.0 2.4 2 0 0 2 2 2 2 Fungal fruit body lectin PP-binding PF00550.25 EXF79656.1 - 0.0047 17.2 0.2 0.039 14.3 0.1 2.4 2 0 0 2 2 2 1 Phosphopantetheine attachment site KR PF08659.10 EXF79656.1 - 0.0061 16.5 0.0 0.072 13.0 0.0 2.4 2 0 0 2 2 2 1 KR domain RmlD_sub_bind PF04321.17 EXF79656.1 - 0.037 13.1 0.0 0.13 11.3 0.0 1.7 2 0 0 2 2 2 0 RmlD substrate binding domain ApbA PF02558.16 EXF79658.1 - 6.1e-24 84.4 0.0 9.9e-24 83.7 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA ApbA_C PF08546.11 EXF79658.1 - 2e-21 76.5 0.0 3.1e-21 75.9 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal EF-hand_1 PF00036.32 EXF79659.1 - 1.7e-25 86.6 4.7 5.4e-06 25.6 0.0 5.4 5 0 0 5 5 5 5 EF hand EF-hand_7 PF13499.6 EXF79659.1 - 1.2e-21 76.9 2.3 3.3e-09 37.1 0.0 3.5 3 1 0 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 EXF79659.1 - 9.2e-21 72.0 4.4 0.0022 17.8 0.1 5.3 5 0 0 5 5 5 5 EF-hand domain EF-hand_8 PF13833.6 EXF79659.1 - 6.8e-18 64.3 7.5 3.5e-09 36.4 0.0 4.9 3 2 2 5 5 5 5 EF-hand domain pair EF-hand_5 PF13202.6 EXF79659.1 - 5.8e-16 57.2 2.0 0.0021 17.5 0.1 4.5 4 0 0 4 4 4 4 EF hand SPX PF03105.19 EXF79659.1 - 0.14 12.1 1.8 0.16 11.9 1.8 1.1 1 0 0 1 1 1 0 SPX domain ChaC PF04752.12 EXF79660.1 - 4.8e-37 127.7 0.0 6.4e-37 127.3 0.0 1.1 1 0 0 1 1 1 1 ChaC-like protein RRM_1 PF00076.22 EXF79661.1 - 2.6e-22 78.4 0.0 3.4e-22 78.1 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EXF79661.1 - 0.0024 17.9 0.0 0.0045 17.1 0.0 1.4 1 1 0 1 1 1 1 RNA recognition motif RRM_occluded PF16842.5 EXF79661.1 - 0.046 13.6 0.0 0.062 13.2 0.0 1.2 1 0 0 1 1 1 0 Occluded RNA-recognition motif PAP_PilO PF06864.12 EXF79661.1 - 0.067 12.0 0.1 0.083 11.7 0.1 1.1 1 0 0 1 1 1 0 Pilin accessory protein (PilO) DUF2076 PF09849.9 EXF79661.1 - 5.2 7.0 10.1 7.1 6.6 10.1 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) COX4 PF02936.14 EXF79662.1 - 2e-48 163.9 0.1 2.3e-48 163.7 0.1 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit IV Alpha-amylase_C PF02806.18 EXF79663.1 - 2.2e-26 92.2 0.1 7.8e-26 90.4 0.1 2.0 2 0 0 2 2 2 1 Alpha amylase, C-terminal all-beta domain CBM_48 PF02922.18 EXF79663.1 - 2e-18 66.5 0.0 6.6e-18 64.9 0.0 2.0 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Alpha-amylase PF00128.24 EXF79663.1 - 3.2e-15 56.5 0.1 1.8e-11 44.2 0.1 2.4 1 1 1 2 2 2 2 Alpha amylase, catalytic domain AMPK1_CBM PF16561.5 EXF79663.1 - 0.018 15.2 0.0 0.05 13.8 0.0 1.7 1 0 0 1 1 1 0 Glycogen recognition site of AMP-activated protein kinase AAA_2 PF07724.14 EXF79664.1 - 1.8e-31 109.6 0.0 3.7e-31 108.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA PF00004.29 EXF79664.1 - 3.5e-12 46.9 0.0 6.8e-12 46.0 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.9 EXF79664.1 - 7e-09 35.6 0.0 1.5e-08 34.6 0.0 1.5 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.14 EXF79664.1 - 5.2e-08 33.0 0.0 1.1e-07 31.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EXF79664.1 - 7.7e-05 23.0 0.3 0.0021 18.3 0.3 2.5 1 1 0 1 1 1 1 AAA domain MCM PF00493.23 EXF79664.1 - 0.00022 20.4 0.0 0.00044 19.4 0.0 1.4 1 0 0 1 1 1 1 MCM P-loop domain AAA_14 PF13173.6 EXF79664.1 - 0.0052 16.8 0.0 0.012 15.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EXF79664.1 - 0.007 16.8 0.1 0.032 14.6 0.0 2.0 1 1 1 2 2 2 1 AAA ATPase domain AAA_7 PF12775.7 EXF79664.1 - 0.008 15.7 0.0 0.014 14.9 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_18 PF13238.6 EXF79664.1 - 0.012 16.2 0.0 0.032 14.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 EXF79664.1 - 0.024 14.4 0.0 0.044 13.5 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein TniB PF05621.11 EXF79664.1 - 0.087 12.2 0.0 0.55 9.6 0.0 2.0 2 0 0 2 2 2 0 Bacterial TniB protein ABC_tran PF00005.27 EXF79664.1 - 0.14 12.7 0.1 0.28 11.7 0.1 1.5 1 0 0 1 1 1 0 ABC transporter Rad17 PF03215.15 EXF79664.1 - 0.14 12.0 0.0 0.24 11.3 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_24 PF13479.6 EXF79664.1 - 0.16 11.6 0.0 0.26 11.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain ATP-synt_ab PF00006.25 EXF79665.1 - 7.2e-62 208.8 0.0 1.1e-61 208.2 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 EXF79665.1 - 8.7e-24 83.8 0.2 2.4e-23 82.4 0.2 1.8 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain AAA PF00004.29 EXF79665.1 - 0.0087 16.5 0.1 0.52 10.7 0.0 2.7 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 EXF79665.1 - 0.012 15.6 0.7 0.028 14.3 0.1 1.9 2 0 0 2 2 2 0 RsgA GTPase NB-ARC PF00931.22 EXF79665.1 - 0.015 14.5 0.4 0.082 12.1 0.1 2.0 2 0 0 2 2 2 0 NB-ARC domain ATPase_2 PF01637.18 EXF79665.1 - 0.031 14.2 0.0 0.079 12.9 0.0 1.6 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea ATPase PF06745.13 EXF79665.1 - 0.037 13.4 0.2 0.065 12.6 0.2 1.4 1 0 0 1 1 1 0 KaiC NACHT PF05729.12 EXF79665.1 - 0.053 13.4 0.1 0.13 12.2 0.0 1.6 2 0 0 2 2 2 0 NACHT domain T3SS_ATPase_C PF18269.1 EXF79665.1 - 0.059 13.2 0.7 0.32 10.9 0.7 2.1 1 1 0 1 1 1 0 T3SS EscN ATPase C-terminal domain AAA_19 PF13245.6 EXF79665.1 - 0.065 13.6 2.0 0.48 10.8 0.2 2.4 3 0 0 3 3 2 0 AAA domain RNA_helicase PF00910.22 EXF79665.1 - 0.078 13.4 0.0 0.17 12.3 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_16 PF13191.6 EXF79665.1 - 0.12 12.7 0.3 0.4 11.0 0.1 2.0 2 1 0 2 2 2 0 AAA ATPase domain DUF4050 PF13259.6 EXF79666.1 - 5.6e-62 209.3 0.1 5.6e-62 209.3 0.1 3.5 2 1 0 2 2 2 1 Protein of unknown function (DUF4050) Astro_capsid_p PF12226.8 EXF79666.1 - 6.6 5.8 11.5 12 5.0 11.5 1.3 1 0 0 1 1 1 0 Turkey astrovirus capsid protein PAPA-1 PF04795.12 EXF79667.1 - 2.1e-21 76.5 15.4 1.6e-13 51.3 0.1 3.2 3 0 0 3 3 3 2 PAPA-1-like conserved region CTNNBL PF08216.11 EXF79667.1 - 0.095 12.9 0.1 0.18 12.0 0.1 1.5 1 0 0 1 1 1 0 Catenin-beta-like, Arm-motif containing nuclear Pex14_N PF04695.13 EXF79668.1 - 8.7e-41 140.2 5.7 8.7e-41 140.2 5.7 2.4 2 0 0 2 2 2 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Ribosomal_60s PF00428.19 EXF79668.1 - 1.1 9.9 11.6 0.18 12.4 3.6 2.8 2 1 0 2 2 2 0 60s Acidic ribosomal protein Chromo PF00385.24 EXF79669.1 - 2.7e-08 33.6 0.4 8e-08 32.1 0.4 1.9 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Ras PF00071.22 EXF79670.1 - 2.7e-63 212.4 0.2 3.2e-63 212.2 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EXF79670.1 - 2.8e-35 121.1 0.2 3.9e-35 120.7 0.2 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EXF79670.1 - 4.7e-13 49.0 0.1 6e-13 48.6 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EXF79670.1 - 8.1e-08 32.3 0.1 1.2e-07 31.8 0.1 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EXF79670.1 - 0.00035 20.2 0.1 0.0018 17.9 0.0 1.9 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EXF79670.1 - 0.00043 19.7 0.1 0.00065 19.1 0.1 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 EXF79670.1 - 0.00054 19.9 0.8 0.018 15.0 0.1 2.1 1 1 0 2 2 2 1 RsgA GTPase AAA_22 PF13401.6 EXF79670.1 - 0.0031 17.8 0.0 0.019 15.3 0.0 2.0 1 1 0 1 1 1 1 AAA domain SRPRB PF09439.10 EXF79670.1 - 0.015 14.7 0.0 0.026 13.9 0.0 1.3 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_14 PF13173.6 EXF79670.1 - 0.018 15.1 0.1 0.047 13.7 0.1 1.7 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EXF79670.1 - 0.02 15.3 0.1 0.032 14.6 0.1 1.5 1 1 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.27 EXF79670.1 - 0.022 15.2 0.1 0.032 14.7 0.1 1.4 1 1 0 1 1 1 0 ABC transporter AAA_24 PF13479.6 EXF79670.1 - 0.03 14.1 0.1 0.064 13.0 0.1 1.7 1 1 0 1 1 1 0 AAA domain TniB PF05621.11 EXF79670.1 - 0.033 13.6 0.0 0.17 11.3 0.0 1.9 2 0 0 2 2 2 0 Bacterial TniB protein AAA_21 PF13304.6 EXF79670.1 - 0.095 12.5 0.5 0.14 11.9 0.5 1.4 1 1 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system SpoIIID PF12116.8 EXF79670.1 - 0.1 12.7 0.1 1.9 8.6 0.0 2.2 2 0 0 2 2 2 0 Stage III sporulation protein D FeoB_N PF02421.18 EXF79670.1 - 0.1 12.1 0.0 0.24 10.9 0.0 1.6 2 0 0 2 2 2 0 Ferrous iron transport protein B MCM PF00493.23 EXF79670.1 - 0.11 11.5 0.0 0.22 10.6 0.0 1.5 1 1 0 1 1 1 0 MCM P-loop domain AAA_7 PF12775.7 EXF79670.1 - 0.12 11.9 0.0 0.21 11.1 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region Brix PF04427.18 EXF79671.1 - 6.4e-33 114.5 0.0 9.3e-33 114.0 0.0 1.2 1 0 0 1 1 1 1 Brix domain F-box-like PF12937.7 EXF79672.1 - 0.002 18.0 0.2 0.12 12.3 0.0 2.6 3 0 0 3 3 3 1 F-box-like F-box PF00646.33 EXF79672.1 - 0.0039 17.0 0.0 0.0091 15.9 0.0 1.6 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 EXF79672.1 - 0.077 12.9 0.0 0.14 12.1 0.0 1.4 1 0 0 1 1 1 0 F-box Arb2 PF09757.9 EXF79673.1 - 2.1e-95 318.7 0.0 3.9e-95 317.9 0.0 1.4 1 0 0 1 1 1 1 Arb2 domain Hist_deacetyl PF00850.19 EXF79673.1 - 8.8e-82 275.0 0.0 2e-81 273.8 0.0 1.6 2 0 0 2 2 2 1 Histone deacetylase domain VEFS-Box PF09733.9 EXF79676.1 - 4.8e-06 26.4 0.0 1e-05 25.4 0.0 1.5 1 0 0 1 1 1 1 VEFS-Box of polycomb protein PHD PF00628.29 EXF79676.1 - 0.0012 18.7 3.7 0.0012 18.7 3.7 2.1 3 0 0 3 3 3 1 PHD-finger MTHFR_C PF12225.8 EXF79676.1 - 0.31 10.7 2.5 0.77 9.5 2.5 1.6 1 0 0 1 1 1 0 Methylene-tetrahydrofolate reductase C terminal zf-C2H2 PF00096.26 EXF79676.1 - 1.7 9.3 5.5 2.2 8.9 0.3 3.4 3 0 0 3 3 3 0 Zinc finger, C2H2 type DUF382 PF04037.13 EXF79677.1 - 1.4e-58 196.6 0.8 1.4e-58 196.6 0.8 2.3 3 0 0 3 3 3 1 Domain of unknown function (DUF382) PSP PF04046.16 EXF79677.1 - 5.7e-18 64.5 3.5 1.1e-17 63.6 3.5 1.5 1 0 0 1 1 1 1 PSP COX4 PF02936.14 EXF79677.1 - 0.18 11.8 0.1 0.18 11.8 0.1 2.3 3 0 0 3 3 3 0 Cytochrome c oxidase subunit IV TPT PF03151.16 EXF79678.1 - 1.1e-56 192.4 10.5 1.3e-56 192.1 10.5 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 EXF79678.1 - 4.2e-11 43.2 30.8 1e-05 25.7 11.0 3.3 2 1 0 2 2 2 2 EamA-like transporter family UAA PF08449.11 EXF79678.1 - 4.7e-06 26.0 16.1 9.3e-05 21.8 16.1 2.1 1 1 0 1 1 1 1 UAA transporter family PUNUT PF16913.5 EXF79678.1 - 0.0055 16.0 11.1 0.0073 15.6 10.6 1.4 1 1 0 1 1 1 1 Purine nucleobase transmembrane transport Multi_Drug_Res PF00893.19 EXF79678.1 - 6.7 7.4 9.7 4.9 7.9 0.7 3.6 2 1 1 4 4 4 0 Small Multidrug Resistance protein ORC5_C PF14630.6 EXF79679.1 - 5.9e-85 285.2 0.0 1e-84 284.5 0.0 1.4 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 5 C-terminus AAA_16 PF13191.6 EXF79679.1 - 5.9e-18 65.8 0.0 1.1e-17 65.0 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain TniB PF05621.11 EXF79679.1 - 0.0055 16.1 0.0 0.0084 15.5 0.0 1.2 1 0 0 1 1 1 1 Bacterial TniB protein FtsK_SpoIIIE PF01580.18 EXF79679.1 - 0.031 13.6 0.0 0.051 12.9 0.0 1.2 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_22 PF13401.6 EXF79679.1 - 0.048 13.9 0.0 0.12 12.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 EXF79679.1 - 0.058 13.3 0.0 0.13 12.2 0.0 1.6 1 0 0 1 1 1 0 NACHT domain DUF815 PF05673.13 EXF79679.1 - 0.11 11.6 0.0 0.28 10.3 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Septin PF00735.18 EXF79679.1 - 0.24 10.7 0.0 0.35 10.1 0.0 1.2 1 0 0 1 1 1 0 Septin Zn_clus PF00172.18 EXF79680.1 - 2e-07 31.0 12.0 3.2e-07 30.4 12.0 1.2 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EXF79680.1 - 0.0096 14.8 0.0 0.014 14.2 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain AMP-binding PF00501.28 EXF79681.1 - 8.2e-80 268.5 0.0 5e-76 256.0 0.0 2.2 2 0 0 2 2 2 2 AMP-binding enzyme Condensation PF00668.20 EXF79681.1 - 1.1e-60 205.7 0.0 1e-33 116.7 0.0 3.1 3 0 0 3 3 3 2 Condensation domain PP-binding PF00550.25 EXF79681.1 - 2e-26 92.1 0.4 7.2e-12 45.5 0.0 3.4 3 0 0 3 3 3 2 Phosphopantetheine attachment site zf-C2H2 PF00096.26 EXF79681.1 - 0.0001 22.5 37.5 0.36 11.4 0.2 7.6 7 0 0 7 7 7 4 Zinc finger, C2H2 type JmjN PF02375.17 EXF79681.1 - 0.15 12.0 0.6 0.88 9.6 0.1 2.3 2 0 0 2 2 2 0 jmjN domain zf-C2H2_2 PF12756.7 EXF79681.1 - 0.17 12.2 15.5 0.87 10.0 1.5 4.5 3 1 0 4 4 4 0 C2H2 type zinc-finger (2 copies) zf-LYAR PF08790.11 EXF79681.1 - 0.28 11.1 2.7 6.6 6.7 0.1 3.5 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger zf-C2HE PF16278.5 EXF79681.1 - 0.98 9.9 4.5 56 4.3 0.0 3.4 2 1 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_jaz PF12171.8 EXF79681.1 - 4.8 7.6 12.1 0.23 11.8 1.1 4.0 5 0 0 5 5 5 0 Zinc-finger double-stranded RNA-binding zf_C2H2_ZHX PF18387.1 EXF79681.1 - 5.5 6.7 7.9 1.1 9.0 2.8 2.6 2 0 0 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain Cortexin PF11057.8 EXF79682.1 - 0.057 13.3 0.2 0.18 11.6 0.1 1.8 2 0 0 2 2 2 0 Cortexin of kidney CD34_antigen PF06365.12 EXF79682.1 - 0.17 11.5 0.3 0.36 10.4 0.0 1.6 2 0 0 2 2 2 0 CD34/Podocalyxin family SLD3 PF08639.10 EXF79683.1 - 8.2e-176 585.9 0.4 8.2e-176 585.9 0.4 1.8 2 0 0 2 2 2 1 DNA replication regulator SLD3 Trs65 PF12735.7 EXF79684.1 - 6.3e-125 416.8 0.0 8.6e-125 416.3 0.0 1.2 1 0 0 1 1 1 1 TRAPP trafficking subunit Trs65 FF PF01846.19 EXF79685.1 - 2.9e-43 145.8 25.1 4.2e-14 52.5 0.3 7.0 7 1 0 7 7 7 4 FF domain WW PF00397.26 EXF79685.1 - 1.9e-18 66.2 18.0 5.4e-11 42.4 4.1 2.7 2 0 0 2 2 2 2 WW domain Lipin_mid PF16876.5 EXF79685.1 - 0.066 13.4 1.2 5.7 7.1 0.8 3.1 1 1 1 2 2 2 0 Lipin/Ned1/Smp2 multi-domain protein middle domain HycH PF07450.11 EXF79685.1 - 0.11 12.9 0.0 0.28 11.6 0.0 1.7 1 0 0 1 1 1 0 Formate hydrogenlyase maturation protein HycH Glyco_hyd_101C PF17451.2 EXF79685.1 - 0.56 10.5 7.9 14 6.0 0.2 3.0 1 1 1 2 2 2 0 Glycosyl hydrolase 101 beta sandwich domain RhoGAP-FF1 PF16512.5 EXF79685.1 - 0.8 10.4 12.1 0.87 10.3 0.2 4.4 3 1 1 4 4 4 0 p190-A and -B Rho GAPs FF domain ABC_tran PF00005.27 EXF79686.1 - 2.6e-33 115.4 0.0 1.9e-15 57.6 0.0 2.5 2 0 0 2 2 2 2 ABC transporter RLI PF04068.15 EXF79686.1 - 5.6e-13 48.5 5.9 5.6e-13 48.5 5.9 1.9 2 0 0 2 2 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI SMC_N PF02463.19 EXF79686.1 - 1.4e-11 44.3 0.5 0.00051 19.5 0.0 3.4 2 2 1 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EXF79686.1 - 1.1e-10 41.8 5.4 0.22 11.3 1.8 4.6 3 2 2 5 5 4 4 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 EXF79686.1 - 4.3e-06 27.2 0.0 0.031 14.7 0.0 2.5 2 1 0 2 2 2 2 AAA ATPase domain AAA PF00004.29 EXF79686.1 - 1.5e-05 25.4 0.0 0.016 15.7 0.1 2.5 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EXF79686.1 - 1.5e-05 25.2 0.0 0.0034 17.7 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_15 PF13175.6 EXF79686.1 - 2.7e-05 24.1 0.2 0.17 11.6 0.0 3.0 2 1 1 3 3 3 2 AAA ATPase domain AAA_23 PF13476.6 EXF79686.1 - 7.4e-05 23.3 0.0 0.018 15.5 0.0 2.4 2 0 0 2 2 2 1 AAA domain Fer4 PF00037.27 EXF79686.1 - 0.00011 21.8 1.3 0.00011 21.8 1.3 2.9 3 0 0 3 3 3 1 4Fe-4S binding domain RsgA_GTPase PF03193.16 EXF79686.1 - 0.00013 22.0 0.1 0.3 11.0 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase Fer4_10 PF13237.6 EXF79686.1 - 0.00013 22.0 8.3 0.01 15.9 0.1 2.4 2 0 0 2 2 2 2 4Fe-4S dicluster domain AAA_18 PF13238.6 EXF79686.1 - 0.0002 21.9 0.1 1.1 9.8 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.6 EXF79686.1 - 0.00026 20.7 0.3 0.49 10.2 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain Rad17 PF03215.15 EXF79686.1 - 0.00039 20.4 0.0 0.049 13.5 0.0 2.4 2 0 0 2 2 2 1 Rad17 P-loop domain RNA_helicase PF00910.22 EXF79686.1 - 0.00064 20.1 0.1 0.36 11.2 0.0 2.8 2 0 0 2 2 2 1 RNA helicase Fer4_6 PF12837.7 EXF79686.1 - 0.0016 18.4 11.7 0.019 15.0 1.1 2.5 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_21 PF14697.6 EXF79686.1 - 0.0018 18.4 10.8 0.0037 17.4 10.8 1.5 1 0 0 1 1 1 1 4Fe-4S dicluster domain NACHT PF05729.12 EXF79686.1 - 0.0023 17.9 1.0 0.27 11.1 0.0 2.5 2 0 0 2 2 2 1 NACHT domain AAA_24 PF13479.6 EXF79686.1 - 0.0026 17.5 2.2 0.22 11.2 0.1 2.7 2 1 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EXF79686.1 - 0.0028 17.8 0.0 0.5 10.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain Thymidylate_kin PF02223.17 EXF79686.1 - 0.0033 17.1 0.1 2.3 7.9 0.0 3.1 3 0 0 3 3 3 1 Thymidylate kinase SRP54 PF00448.22 EXF79686.1 - 0.0034 17.1 3.0 0.097 12.3 0.1 2.3 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_13 PF13166.6 EXF79686.1 - 0.0039 15.9 0.0 0.0039 15.9 0.0 1.9 3 0 0 3 3 2 1 AAA domain TsaE PF02367.17 EXF79686.1 - 0.0049 16.9 0.1 0.052 13.5 0.0 2.2 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE Fer4_7 PF12838.7 EXF79686.1 - 0.0057 17.2 7.4 0.015 15.8 0.3 2.5 2 0 0 2 2 2 1 4Fe-4S dicluster domain AAA_5 PF07728.14 EXF79686.1 - 0.0063 16.5 0.2 0.3 11.1 0.0 2.5 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_28 PF13521.6 EXF79686.1 - 0.0086 16.3 0.2 1.5 9.1 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 EXF79686.1 - 0.012 15.1 0.2 0.22 11.0 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region NB-ARC PF00931.22 EXF79686.1 - 0.02 14.1 0.1 1.5 7.9 0.0 2.4 3 0 0 3 3 2 0 NB-ARC domain Fer4_9 PF13187.6 EXF79686.1 - 0.024 14.8 9.9 0.058 13.6 10.0 1.7 1 1 0 1 1 1 0 4Fe-4S dicluster domain AAA_30 PF13604.6 EXF79686.1 - 0.06 13.1 0.2 3.7 7.2 0.0 2.5 2 0 0 2 2 2 0 AAA domain Fer4_16 PF13484.6 EXF79686.1 - 0.075 14.0 0.3 0.075 14.0 0.3 2.7 2 0 0 2 2 2 0 4Fe-4S double cluster binding domain VirE PF05272.11 EXF79686.1 - 0.12 12.1 0.0 8.2 6.1 0.0 2.5 2 0 0 2 2 2 0 Virulence-associated protein E MMR_HSR1 PF01926.23 EXF79686.1 - 0.14 12.2 1.1 18 5.5 0.0 2.7 2 1 0 2 2 2 0 50S ribosome-binding GTPase ATPase PF06745.13 EXF79686.1 - 0.18 11.1 0.0 0.45 9.8 0.0 1.7 1 0 0 1 1 1 0 KaiC NTPase_1 PF03266.15 EXF79686.1 - 0.25 11.2 1.6 6.6 6.6 0.1 2.6 2 0 0 2 2 2 0 NTPase AAA_14 PF13173.6 EXF79686.1 - 0.3 11.1 1.3 24 5.0 0.0 3.3 3 1 0 3 3 2 0 AAA domain PduV-EutP PF10662.9 EXF79686.1 - 0.31 10.8 2.8 0.62 9.8 0.0 2.6 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation Fer4_2 PF12797.7 EXF79686.1 - 1.4 9.2 10.5 0.48 10.6 1.1 2.6 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_8 PF13183.6 EXF79686.1 - 3.6 8.1 10.8 0.62 10.6 1.6 2.4 1 1 1 2 2 2 0 4Fe-4S dicluster domain SNF2_N PF00176.23 EXF79687.1 - 1.3e-54 185.3 0.1 2e-54 184.6 0.1 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Chromo PF00385.24 EXF79687.1 - 1.8e-24 85.4 6.9 1.1e-15 57.3 1.2 2.9 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Helicase_C PF00271.31 EXF79687.1 - 6.5e-20 71.5 0.0 1.8e-19 70.1 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF4208 PF13907.6 EXF79687.1 - 2.9e-17 62.9 0.0 9e-17 61.3 0.0 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF4208) HDA2-3 PF11496.8 EXF79687.1 - 3.4e-08 33.0 0.0 9.8e-08 31.5 0.0 1.7 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 ResIII PF04851.15 EXF79687.1 - 2.6e-07 30.8 0.0 1.9e-06 28.0 0.0 2.5 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Cdh1_DBD_1 PF18196.1 EXF79687.1 - 4.4e-05 23.8 0.1 4.4e-05 23.8 0.1 4.9 3 1 1 4 4 4 2 Chromodomain helicase DNA-binding domain 1 AAA_22 PF13401.6 EXF79687.1 - 0.0014 18.9 0.0 0.0061 16.8 0.0 2.1 2 0 0 2 2 2 1 AAA domain CDH1_2_SANT_HL1 PF18375.1 EXF79687.1 - 0.0016 19.0 1.1 0.0016 19.0 1.1 2.7 3 0 0 3 3 1 1 CDH1/2 SANT-Helical linker 1 SLIDE PF09111.10 EXF79687.1 - 0.0025 17.8 1.3 0.028 14.4 0.0 3.0 2 1 0 2 2 2 1 SLIDE CHDCT2 PF08074.11 EXF79687.1 - 0.51 10.5 0.0 0.51 10.5 0.0 3.0 4 0 0 4 4 4 0 CHDCT2 (NUC038) domain SIR2 PF02146.17 EXF79688.1 - 1e-24 87.5 0.0 2.4e-24 86.2 0.0 1.6 1 1 0 1 1 1 1 Sir2 family Med16 PF11635.8 EXF79689.1 - 3.6e-77 260.0 0.0 5.2e-77 259.5 0.0 1.2 1 0 0 1 1 1 1 Mediator complex subunit 16 Herpes_capsid PF06112.11 EXF79689.1 - 0.048 13.7 1.3 0.11 12.6 1.3 1.5 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein Ammonium_transp PF00909.21 EXF79690.1 - 9.5e-118 393.3 26.7 1.1e-117 393.1 26.7 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family Phage_holin_2_1 PF04971.12 EXF79690.1 - 4.9 7.2 7.8 1 9.4 0.9 3.2 3 0 0 3 3 3 0 Bacteriophage P21 holin S DNA_pol_B_palm PF14792.6 EXF79691.1 - 2.8e-34 117.8 0.0 6.1e-34 116.7 0.0 1.6 1 0 0 1 1 1 1 DNA polymerase beta palm DNA_pol_B_thumb PF14791.6 EXF79691.1 - 7.3e-25 86.9 0.0 4.6e-24 84.4 0.1 2.3 2 0 0 2 2 2 1 DNA polymerase beta thumb DNA_pol_lambd_f PF10391.9 EXF79691.1 - 5.9e-20 70.8 0.2 1.9e-19 69.2 0.2 2.0 1 0 0 1 1 1 1 Fingers domain of DNA polymerase lambda HHH_8 PF14716.6 EXF79691.1 - 1.4e-17 63.8 0.1 6.1e-17 61.7 0.1 2.2 1 0 0 1 1 1 1 Helix-hairpin-helix domain HHH_5 PF14520.6 EXF79691.1 - 0.017 15.7 0.6 4 8.1 0.0 3.0 3 0 0 3 3 3 0 Helix-hairpin-helix domain NTP_transf_2 PF01909.23 EXF79691.1 - 0.02 15.2 0.0 0.051 13.9 0.0 1.6 1 0 0 1 1 1 0 Nucleotidyltransferase domain Cdd1 PF11731.8 EXF79691.1 - 0.06 13.6 0.0 3.4 8.0 0.0 2.7 1 1 1 2 2 2 0 Pathogenicity locus BRCT_2 PF16589.5 EXF79691.1 - 0.062 13.7 0.0 0.14 12.5 0.0 1.6 1 0 0 1 1 1 0 BRCT domain, a BRCA1 C-terminus domain HTH_3 PF01381.22 EXF79691.1 - 0.082 13.0 0.0 0.21 11.7 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix BRCT PF00533.26 EXF79691.1 - 0.095 13.1 0.0 0.25 11.8 0.0 1.8 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain Methyltransf_25 PF13649.6 EXF79692.1 - 2e-10 41.3 0.0 5.3e-10 39.9 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain PrmA PF06325.13 EXF79692.1 - 5.2e-10 39.2 0.0 8.1e-10 38.6 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.6 EXF79692.1 - 1.1e-08 35.1 0.0 1.7e-08 34.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF79692.1 - 1.2e-07 32.3 0.0 6.1e-07 30.0 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_9 PF08003.11 EXF79692.1 - 1.1e-05 24.6 0.1 1.5e-05 24.1 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_23 PF13489.6 EXF79692.1 - 8.7e-05 22.4 0.0 0.00024 21.0 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.7 EXF79692.1 - 0.00028 20.9 0.1 0.00047 20.1 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF79692.1 - 0.0014 19.3 0.0 0.0032 18.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EXF79692.1 - 0.0046 16.3 0.0 0.006 15.9 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase PRMT5 PF05185.16 EXF79692.1 - 0.011 15.6 0.1 0.022 14.6 0.1 1.5 1 1 0 1 1 1 0 PRMT5 arginine-N-methyltransferase MTS PF05175.14 EXF79692.1 - 0.019 14.5 0.0 0.03 13.9 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_32 PF13679.6 EXF79692.1 - 0.086 12.8 0.0 0.15 12.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain IPI_T4 PF11634.8 EXF79692.1 - 0.11 12.5 0.1 20 5.3 0.1 2.6 2 0 0 2 2 2 0 Nuclease inhibitor from bacteriophage T4 PMG PF05287.12 EXF79695.1 - 1.6e-05 25.0 6.9 1.6e-05 25.0 6.9 1.6 1 1 0 2 2 2 1 PMG protein Lamprin PF06403.11 EXF79695.1 - 1.2 9.1 10.2 2.3 8.2 10.2 1.4 1 0 0 1 1 1 0 Lamprin Pyridoxal_deC PF00282.19 EXF79696.1 - 0.00017 20.4 0.1 0.00021 20.2 0.1 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Cytochrom_B562 PF07361.11 EXF79696.1 - 0.14 12.9 0.0 0.2 12.3 0.0 1.3 1 0 0 1 1 1 0 Cytochrome b562 NmrA PF05368.13 EXF79697.1 - 2.9e-13 49.9 0.0 6.7e-13 48.7 0.0 1.5 2 0 0 2 2 2 1 NmrA-like family NAD_binding_10 PF13460.6 EXF79697.1 - 0.00065 19.6 0.0 0.0015 18.5 0.0 1.7 1 1 0 1 1 1 1 NAD(P)H-binding L1R_F9L PF02442.17 EXF79697.1 - 0.1 12.5 0.0 0.19 11.5 0.0 1.4 1 0 0 1 1 1 0 Lipid membrane protein of large eukaryotic DNA viruses Abhydrolase_1 PF00561.20 EXF79698.1 - 1e-23 84.3 0.0 6.5e-21 75.1 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_4 PF08386.10 EXF79698.1 - 5e-18 65.1 0.0 1.2e-17 63.9 0.0 1.7 1 0 0 1 1 1 1 TAP-like protein Peptidase_M3 PF01432.20 EXF79699.1 - 5.3e-121 405.1 0.0 6.9e-121 404.7 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M3 Peptidase_M50B PF13398.6 EXF79699.1 - 0.083 12.5 0.0 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 Peptidase M50B-like ApoO PF09769.9 EXF79700.1 - 1.5e-42 144.6 0.4 1.8e-41 141.1 0.1 2.1 2 0 0 2 2 2 1 Apolipoprotein O Dus PF01207.17 EXF79701.1 - 3e-43 148.1 0.1 1.6e-42 145.7 0.1 1.8 1 1 0 1 1 1 1 Dihydrouridine synthase (Dus) Plus-3 PF03126.18 EXF79701.1 - 0.08 13.5 0.0 0.14 12.7 0.0 1.3 1 0 0 1 1 1 0 Plus-3 domain PucR PF07905.11 EXF79701.1 - 0.13 12.5 0.1 0.5 10.7 0.0 2.0 1 1 0 1 1 1 0 Purine catabolism regulatory protein-like family Pyrophosphatase PF00719.19 EXF79702.1 - 6.2e-55 185.4 0.1 8.8e-55 184.9 0.1 1.2 1 0 0 1 1 1 1 Inorganic pyrophosphatase MRP_L53 PF10780.9 EXF79703.1 - 6.2e-21 74.3 0.4 8.8e-21 73.8 0.4 1.2 1 0 0 1 1 1 1 39S ribosomal protein L53/MRP-L53 VioE PF18234.1 EXF79703.1 - 0.069 13.3 0.0 0.069 13.3 0.0 1.1 1 0 0 1 1 1 0 Violacein biosynthetic enzyme VioE DUF2442 PF10387.9 EXF79703.1 - 0.073 13.4 0.0 0.11 12.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2442) Sec20 PF03908.13 EXF79704.1 - 3.3e-13 49.4 3.0 3.9e-13 49.1 0.0 2.5 3 0 0 3 3 3 1 Sec20 ALMT PF11744.8 EXF79704.1 - 0.57 9.0 5.5 0.8 8.5 5.5 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter zf-Tim10_DDP PF02953.15 EXF79705.1 - 0.11 12.2 8.0 5.3 6.8 6.1 3.0 2 1 0 2 2 2 0 Tim10/DDP family zinc finger Aldolase_II PF00596.21 EXF79706.1 - 1.5e-40 139.1 0.0 1.7e-40 138.9 0.0 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain Calreticulin PF00262.18 EXF79707.1 - 1e-169 564.2 19.5 1.5e-169 563.6 19.5 1.3 1 0 0 1 1 1 1 Calreticulin family DUF1911 PF08929.10 EXF79707.1 - 0.02 15.7 0.4 0.12 13.2 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1911) Aldedh PF00171.22 EXF79708.1 - 3.6e-133 444.5 0.2 4.4e-133 444.2 0.2 1.1 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 EXF79708.1 - 0.14 11.2 0.0 0.34 9.9 0.0 1.6 2 0 0 2 2 2 0 Acyl-CoA reductase (LuxC) Myb_DNA-bind_6 PF13921.6 EXF79711.1 - 1.7e-13 50.6 0.6 2.6e-07 30.8 0.0 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 EXF79711.1 - 2.9e-12 46.6 0.2 3.7e-05 23.8 0.1 2.6 2 1 0 2 2 2 2 Myb-like DNA-binding domain AtuA PF07287.11 EXF79711.1 - 0.19 10.4 0.0 0.28 9.9 0.0 1.1 1 0 0 1 1 1 0 Acyclic terpene utilisation family protein AtuA TFCD_C PF12612.8 EXF79713.1 - 7.5e-23 81.3 0.1 2.3e-22 79.8 0.1 1.9 1 0 0 1 1 1 1 Tubulin folding cofactor D C terminal HEAT_2 PF13646.6 EXF79713.1 - 0.0076 16.6 3.4 1.2 9.6 0.1 4.6 4 0 0 4 4 4 1 HEAT repeats HEAT PF02985.22 EXF79713.1 - 0.0086 16.3 2.4 1.6 9.2 0.0 4.8 5 0 0 5 5 5 1 HEAT repeat IFRD PF05004.13 EXF79713.1 - 0.048 12.8 0.2 0.26 10.4 0.3 2.1 2 0 0 2 2 2 0 Interferon-related developmental regulator (IFRD) TetR_C_15 PF17918.1 EXF79713.1 - 4.6 8.0 7.2 2.3 9.0 0.1 4.4 6 0 0 6 6 6 0 Tetracyclin repressor-like, C-terminal domain HET PF06985.11 EXF79714.1 - 5e-25 88.5 0.0 9.6e-24 84.4 0.0 2.5 3 0 0 3 3 3 1 Heterokaryon incompatibility protein (HET) Hat1_N PF10394.9 EXF79715.1 - 3.3e-45 154.2 0.0 8.6e-45 152.8 0.0 1.7 2 0 0 2 2 2 1 Histone acetyl transferase HAT1 N-terminus Acetyltransf_10 PF13673.7 EXF79715.1 - 0.0013 18.7 0.0 0.0026 17.7 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EXF79715.1 - 0.0024 18.1 0.0 0.0053 17.0 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EXF79715.1 - 0.071 13.5 0.0 0.16 12.5 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain AAA_5 PF07728.14 EXF79716.1 - 1.7e-121 400.6 0.0 3.1e-21 75.8 0.0 9.7 9 0 0 9 9 9 9 AAA domain (dynein-related subfamily) AAA_lid_7 PF17867.1 EXF79716.1 - 5.4e-54 180.9 1.1 1.4e-20 73.5 0.0 5.6 5 0 0 5 5 5 3 Midasin AAA lid domain AAA_lid_5 PF17865.1 EXF79716.1 - 4.7e-32 110.2 0.4 1.4e-30 105.5 0.0 3.1 3 0 0 3 3 2 1 Midasin AAA lid domain AAA PF00004.29 EXF79716.1 - 8.5e-29 100.6 0.0 0.00038 20.9 0.0 7.1 6 0 0 6 6 6 5 ATPase family associated with various cellular activities (AAA) AAA_3 PF07726.11 EXF79716.1 - 8.1e-28 96.9 0.0 1.2e-09 38.1 0.0 7.0 7 0 0 7 7 6 3 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 EXF79716.1 - 9.2e-27 93.7 3.3 0.00012 21.7 0.1 7.1 6 1 0 6 6 6 5 P-loop containing dynein motor region AAA_16 PF13191.6 EXF79716.1 - 2e-25 90.2 17.1 0.0012 19.2 0.0 8.8 6 2 0 6 6 6 6 AAA ATPase domain Dynein_heavy PF03028.15 EXF79716.1 - 1.9e-23 82.8 0.0 0.005 16.9 0.0 8.1 7 1 0 7 7 7 4 Dynein heavy chain region D6 P-loop domain AAA_22 PF13401.6 EXF79716.1 - 7.7e-21 74.8 3.3 0.0059 16.9 0.0 8.1 7 0 0 7 7 7 4 AAA domain AAA_6 PF12774.7 EXF79716.1 - 1.2e-18 67.1 0.0 0.0095 14.9 0.0 8.2 8 0 0 8 8 8 4 Hydrolytic ATP binding site of dynein motor region AAA_18 PF13238.6 EXF79716.1 - 2.5e-17 63.7 0.5 0.044 14.3 0.0 7.2 6 0 0 6 6 6 3 AAA domain AAA_33 PF13671.6 EXF79716.1 - 7.2e-17 61.9 0.5 0.013 15.7 0.0 7.4 7 0 0 7 7 6 4 AAA domain Sigma54_activat PF00158.26 EXF79716.1 - 1.2e-16 60.9 0.0 0.11 12.2 0.1 6.6 6 0 0 6 6 6 4 Sigma-54 interaction domain TsaE PF02367.17 EXF79716.1 - 2e-15 56.9 3.4 0.0061 16.6 0.2 6.4 6 0 0 6 6 6 4 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_14 PF13173.6 EXF79716.1 - 2.6e-15 56.6 0.0 0.019 15.0 0.0 7.8 7 0 0 7 7 7 3 AAA domain ABC_tran PF00005.27 EXF79716.1 - 1e-13 52.0 3.3 0.11 13.0 0.1 7.7 6 1 0 6 6 6 2 ABC transporter T2SSE PF00437.20 EXF79716.1 - 2.1e-13 49.9 3.5 0.0063 15.6 0.0 6.5 6 0 0 6 6 6 1 Type II/IV secretion system protein RNA_helicase PF00910.22 EXF79716.1 - 2.9e-13 50.2 0.9 0.67 10.4 0.0 6.8 6 0 0 6 6 6 2 RNA helicase NACHT PF05729.12 EXF79716.1 - 3.9e-13 49.7 5.0 0.081 12.8 0.1 6.1 5 0 0 5 5 5 4 NACHT domain AAA_30 PF13604.6 EXF79716.1 - 7.6e-13 48.6 1.8 0.1 12.3 0.0 7.8 6 2 0 6 6 6 1 AAA domain RuvB_N PF05496.12 EXF79716.1 - 5.8e-12 45.6 2.8 0.027 14.2 0.0 6.0 5 0 0 5 5 5 3 Holliday junction DNA helicase RuvB P-loop domain AAA_25 PF13481.6 EXF79716.1 - 4.2e-11 42.8 2.5 1 8.9 0.0 5.8 5 0 0 5 5 5 2 AAA domain Mg_chelatase PF01078.21 EXF79716.1 - 1.1e-10 41.2 2.5 8.2 5.7 0.0 9.0 9 0 0 9 9 9 0 Magnesium chelatase, subunit ChlI AAA_29 PF13555.6 EXF79716.1 - 1.8e-10 40.4 0.9 0.22 11.3 0.0 6.6 6 0 0 6 6 6 1 P-loop containing region of AAA domain Rad17 PF03215.15 EXF79716.1 - 4e-10 39.9 1.1 0.16 11.9 0.0 6.4 6 0 0 6 6 6 2 Rad17 P-loop domain AAA_28 PF13521.6 EXF79716.1 - 6.8e-10 39.4 4.8 0.65 10.2 0.0 7.3 6 0 0 6 6 6 1 AAA domain Sigma54_activ_2 PF14532.6 EXF79716.1 - 1e-09 38.6 0.4 0.028 14.6 0.0 6.0 6 0 0 6 6 5 2 Sigma-54 interaction domain Zeta_toxin PF06414.12 EXF79716.1 - 1.6e-09 37.3 5.1 0.11 11.7 0.0 7.4 7 0 0 7 7 7 1 Zeta toxin RsgA_GTPase PF03193.16 EXF79716.1 - 2.6e-09 37.2 5.6 0.92 9.4 0.1 6.7 7 0 0 7 7 6 1 RsgA GTPase IstB_IS21 PF01695.17 EXF79716.1 - 5.8e-09 35.9 1.1 0.81 9.4 0.0 6.4 6 0 0 6 6 6 1 IstB-like ATP binding protein NTPase_1 PF03266.15 EXF79716.1 - 1.4e-07 31.6 5.9 1.4 8.8 0.0 6.6 6 0 0 6 6 6 2 NTPase SRP54 PF00448.22 EXF79716.1 - 2.2e-07 30.7 1.7 0.66 9.6 0.1 5.0 5 0 0 5 5 4 1 SRP54-type protein, GTPase domain DUF815 PF05673.13 EXF79716.1 - 1.3e-06 27.8 1.8 0.63 9.2 0.1 5.1 5 0 0 5 5 5 1 Protein of unknown function (DUF815) ATPase_2 PF01637.18 EXF79716.1 - 1.3e-06 28.5 0.0 2.1 8.2 0.0 6.3 6 0 0 6 6 6 1 ATPase domain predominantly from Archaea AAA_24 PF13479.6 EXF79716.1 - 1.3e-06 28.3 2.9 2.1 8.0 0.6 6.7 6 1 0 6 6 6 1 AAA domain AAA_19 PF13245.6 EXF79716.1 - 1.6e-06 28.5 9.5 5 7.4 0.0 6.4 6 1 0 6 6 5 0 AAA domain PduV-EutP PF10662.9 EXF79716.1 - 2.4e-06 27.4 2.5 0.1 12.3 0.0 4.9 5 0 0 5 5 4 1 Ethanolamine utilisation - propanediol utilisation Viral_helicase1 PF01443.18 EXF79716.1 - 1.9e-05 24.5 0.3 0.71 9.6 0.0 5.4 6 0 0 6 6 5 1 Viral (Superfamily 1) RNA helicase cobW PF02492.19 EXF79716.1 - 2.7e-05 23.8 6.1 3.4 7.2 0.0 5.9 6 0 0 6 6 6 0 CobW/HypB/UreG, nucleotide-binding domain dNK PF01712.19 EXF79716.1 - 3.7e-05 23.7 3.7 20 5.0 0.0 5.8 5 0 0 5 5 5 0 Deoxynucleoside kinase TniB PF05621.11 EXF79716.1 - 7.8e-05 22.2 0.9 12 5.3 0.0 6.1 7 0 0 7 7 7 0 Bacterial TniB protein MMR_HSR1 PF01926.23 EXF79716.1 - 8.6e-05 22.6 0.8 48 4.1 0.0 6.3 6 0 0 6 6 5 0 50S ribosome-binding GTPase CbiA PF01656.23 EXF79716.1 - 9.5e-05 22.5 0.0 4.9 7.2 0.0 4.8 4 0 0 4 4 4 0 CobQ/CobB/MinD/ParA nucleotide binding domain TIP49 PF06068.13 EXF79716.1 - 0.00021 20.6 1.1 6.5 5.9 0.0 4.7 5 0 0 5 5 5 0 TIP49 P-loop domain ATPase PF06745.13 EXF79716.1 - 0.00037 19.9 0.8 14 4.9 0.0 5.0 5 0 0 5 5 4 0 KaiC Roc PF08477.13 EXF79716.1 - 0.00068 19.8 5.1 8.2 6.7 0.1 5.8 6 0 0 6 6 5 0 Ras of Complex, Roc, domain of DAPkinase CPT PF07931.12 EXF79716.1 - 0.0011 18.9 2.1 34 4.2 0.0 6.3 7 1 0 7 7 4 0 Chloramphenicol phosphotransferase-like protein NB-ARC PF00931.22 EXF79716.1 - 0.0026 17.0 7.8 4.3 6.5 0.0 5.6 6 0 0 6 6 5 0 NB-ARC domain AAA_9 PF12781.7 EXF79716.1 - 0.006 15.7 0.0 0.41 9.8 0.0 3.4 3 0 0 3 3 3 1 ATP-binding dynein motor region Bac_DnaA PF00308.18 EXF79716.1 - 0.0084 16.0 1.2 35 4.2 0.1 4.8 5 0 0 5 5 4 0 Bacterial dnaA protein KTI12 PF08433.10 EXF79716.1 - 0.014 14.9 0.0 0.95 8.9 0.0 3.7 3 0 0 3 3 3 0 Chromatin associated protein KTI12 DEAD PF00270.29 EXF79716.1 - 0.017 14.9 0.7 3.8 7.3 0.0 3.6 4 0 0 4 4 3 0 DEAD/DEAH box helicase GAF_2 PF13185.6 EXF79716.1 - 0.02 15.2 0.0 0.33 11.2 0.0 3.2 3 0 0 3 3 1 0 GAF domain MeaB PF03308.16 EXF79716.1 - 0.023 13.7 2.1 19 4.1 0.1 3.6 3 0 0 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB DAP3 PF10236.9 EXF79716.1 - 0.026 13.7 6.5 3.2 6.8 0.0 4.6 5 0 0 5 5 5 0 Mitochondrial ribosomal death-associated protein 3 ATP_bind_1 PF03029.17 EXF79716.1 - 0.035 13.9 9.3 22 4.7 0.0 5.9 7 0 0 7 7 6 0 Conserved hypothetical ATP binding protein Ploopntkinase3 PF18751.1 EXF79716.1 - 0.044 13.7 0.2 22 4.9 0.0 4.0 4 0 0 4 4 4 0 P-loop Nucleotide Kinase3 KAP_NTPase PF07693.14 EXF79716.1 - 0.057 12.6 0.0 22 4.1 0.0 4.7 6 0 0 6 6 5 0 KAP family P-loop domain PRK PF00485.18 EXF79716.1 - 0.083 12.6 0.2 36 4.0 0.0 4.1 6 0 0 6 6 3 0 Phosphoribulokinase / Uridine kinase family SRPRB PF09439.10 EXF79716.1 - 0.092 12.2 2.7 21 4.5 0.0 4.7 6 0 0 6 6 4 0 Signal recognition particle receptor beta subunit tRNA_lig_kinase PF08303.11 EXF79716.1 - 0.23 11.5 0.9 1.3 9.1 0.1 2.5 2 0 0 2 2 2 0 tRNA ligase kinase domain DnaB_C PF03796.15 EXF79716.1 - 0.39 10.0 4.0 3.8 6.8 0.0 3.4 4 0 0 4 4 2 0 DnaB-like helicase C terminal domain Ribosomal_L12 PF00542.19 EXF79717.1 - 2.7e-19 69.3 4.9 2.7e-19 69.3 4.9 2.6 3 0 0 3 3 3 1 Ribosomal protein L7/L12 C-terminal domain Ribosomal_L12_N PF16320.5 EXF79717.1 - 4.6e-12 45.4 11.3 4.6e-12 45.4 11.3 3.1 3 1 0 3 3 3 1 Ribosomal protein L7/L12 dimerisation domain Ribosomal_60s PF00428.19 EXF79717.1 - 0.99 10.0 13.9 0.13 12.8 8.6 2.1 2 1 0 2 2 2 0 60s Acidic ribosomal protein CTK3 PF12243.8 EXF79718.1 - 1.5e-50 170.4 0.5 2e-50 169.9 0.5 1.2 1 0 0 1 1 1 1 CTD kinase subunit gamma CTK3 CTK3_C PF12350.8 EXF79718.1 - 1e-21 76.9 5.5 1e-21 76.9 5.5 2.0 2 0 0 2 2 2 1 CTD kinase subunit gamma CTK3 C-terminus Rcd1 PF04078.13 EXF79718.1 - 0.012 14.9 0.0 0.02 14.2 0.0 1.3 1 0 0 1 1 1 0 Cell differentiation family, Rcd1-like P5CR_dimer PF14748.6 EXF79719.1 - 1.7e-35 121.3 1.9 4.2e-35 120.1 1.9 1.6 1 0 0 1 1 1 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.17 EXF79719.1 - 4.3e-12 46.5 0.7 1.6e-10 41.4 0.0 2.5 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent Pyr_redox_2 PF07992.14 EXF79720.1 - 1.4e-44 152.5 0.0 3.1e-39 135.0 0.0 2.1 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EXF79720.1 - 9e-14 51.8 0.0 8.1e-11 42.3 0.0 3.3 3 1 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EXF79720.1 - 7.1e-06 25.5 0.0 0.0085 15.4 0.0 2.7 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EXF79720.1 - 1.5e-05 24.3 0.2 0.82 8.7 0.1 3.4 3 1 1 4 4 4 3 FAD binding domain K_oxygenase PF13434.6 EXF79720.1 - 0.0028 16.9 0.3 7.3 5.6 0.0 3.9 2 2 1 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 EXF79720.1 - 0.029 14.6 0.0 8.8 6.7 0.0 2.7 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain BP28CT PF08146.12 EXF79721.1 - 4.9e-42 143.4 1.7 9.8e-42 142.5 0.2 2.4 2 0 0 2 2 2 1 BP28CT (NUC211) domain U3snoRNP10 PF12397.8 EXF79721.1 - 8.7e-27 93.8 0.0 8.7e-27 93.8 0.0 4.9 5 0 0 5 5 5 1 U3 small nucleolar RNA-associated protein 10 HEAT PF02985.22 EXF79721.1 - 1.1e-05 25.3 11.2 0.037 14.3 0.0 7.0 7 0 0 7 7 7 2 HEAT repeat HEAT_2 PF13646.6 EXF79721.1 - 0.024 15.0 15.8 0.3 11.5 0.0 6.1 7 0 0 7 7 7 0 HEAT repeats Lipase_GDSL_2 PF13472.6 EXF79722.1 - 7.8e-22 78.5 0.0 1.2e-21 77.9 0.0 1.3 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EXF79722.1 - 1.1e-12 48.3 0.0 1.5e-12 47.9 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Isochorismatase PF00857.20 EXF79724.1 - 8.8e-31 107.4 0.1 1.1e-30 107.1 0.1 1.1 1 0 0 1 1 1 1 Isochorismatase family HK PF02110.15 EXF79725.1 - 4.6e-74 248.9 0.6 7.9e-74 248.1 0.6 1.3 1 0 0 1 1 1 1 Hydroxyethylthiazole kinase family TMP-TENI PF02581.17 EXF79725.1 - 7.4e-58 194.9 1.0 1.1e-57 194.3 1.0 1.3 1 0 0 1 1 1 1 Thiamine monophosphate synthase TPP_enzyme_N PF02776.18 EXF79725.1 - 0.01 15.5 0.8 0.043 13.4 0.3 2.2 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain Peripla_BP_6 PF13458.6 EXF79725.1 - 0.03 14.0 3.4 1.3 8.6 0.2 3.4 1 1 2 4 4 4 0 Periplasmic binding protein Fungal_trans PF04082.18 EXF79726.1 - 0.00022 20.3 0.0 0.00044 19.4 0.0 1.4 1 1 0 1 1 1 1 Fungal specific transcription factor domain DENN PF02141.21 EXF79726.1 - 0.056 13.4 0.3 0.11 12.5 0.3 1.4 1 0 0 1 1 1 0 DENN (AEX-3) domain DUF5320 PF17253.2 EXF79726.1 - 0.076 14.1 0.1 2.3 9.4 0.0 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5320) Zn_clus PF00172.18 EXF79726.1 - 0.076 13.2 11.0 0.14 12.3 11.0 1.4 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Aminotran_1_2 PF00155.21 EXF79727.1 - 3.5e-81 273.2 0.0 4.6e-81 272.8 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EXF79727.1 - 3.1e-05 22.7 0.0 4.9e-05 22.0 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 EXF79727.1 - 0.00046 19.3 0.0 0.0009 18.3 0.0 1.5 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 EXF79727.1 - 0.016 14.5 0.3 0.029 13.7 0.3 1.3 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family PTS_EIIA_2 PF00359.22 EXF79727.1 - 0.034 14.1 0.0 0.068 13.1 0.0 1.5 1 0 0 1 1 1 0 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 SNF2_N PF00176.23 EXF79728.1 - 1.8e-43 148.6 0.0 3.5e-43 147.7 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EXF79728.1 - 2.3e-21 76.2 0.1 7.7e-21 74.5 0.1 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EXF79728.1 - 1.5e-06 28.3 0.0 5.2e-06 26.6 0.0 2.1 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit MCPVI PF02993.14 EXF79728.1 - 0.54 10.0 0.0 0.54 10.0 0.0 2.8 3 0 0 3 3 3 0 Minor capsid protein VI GSH_synth_ATP PF03917.17 EXF79729.1 - 1.6e-134 448.4 0.0 1.8e-134 448.2 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic glutathione synthase, ATP binding domain GSH_synthase PF03199.15 EXF79729.1 - 3.5e-33 114.1 0.0 6.3e-33 113.3 0.0 1.4 1 0 0 1 1 1 1 Eukaryotic glutathione synthase SSB PF00436.25 EXF79730.1 - 4.9e-19 68.3 0.0 6.1e-19 68.0 0.0 1.1 1 0 0 1 1 1 1 Single-strand binding protein family Erf4 PF10256.9 EXF79731.1 - 6.7e-40 135.8 0.0 1.2e-39 135.0 0.0 1.4 1 0 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family DUF1604 PF07713.13 EXF79733.1 - 6.2e-41 138.1 0.7 2.1e-40 136.4 0.7 2.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1604) G-patch PF01585.23 EXF79733.1 - 3e-06 27.0 2.1 1.2e-05 25.0 1.4 2.4 2 0 0 2 2 2 1 G-patch domain G-patch_2 PF12656.7 EXF79733.1 - 0.00045 20.3 2.6 0.00053 20.0 0.2 2.4 2 0 0 2 2 2 1 G-patch domain Pkinase PF00069.25 EXF79734.1 - 1.1e-70 238.1 0.0 2.4e-70 236.9 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF79734.1 - 8.6e-40 136.6 0.1 2.8e-39 135.0 0.1 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase KA1 PF02149.19 EXF79734.1 - 4.2e-20 71.3 0.3 7.6e-20 70.5 0.3 1.5 1 0 0 1 1 1 1 Kinase associated domain 1 Haspin_kinase PF12330.8 EXF79734.1 - 3.6e-07 29.5 0.0 6.2e-07 28.7 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EXF79734.1 - 1.5e-05 24.5 0.2 3.4e-05 23.3 0.2 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EXF79734.1 - 5.8e-05 22.6 0.0 0.00013 21.4 0.0 1.5 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 EXF79734.1 - 0.0025 17.8 0.0 0.012 15.6 0.0 2.1 1 1 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 EXF79734.1 - 0.013 15.1 0.0 0.039 13.5 0.0 1.8 1 0 0 1 1 1 0 RIO1 family SDP_N PF12278.8 EXF79734.1 - 0.02 15.0 0.4 0.02 15.0 0.4 4.6 5 0 0 5 5 5 0 Sex determination protein N terminal YrbL-PhoP_reg PF10707.9 EXF79734.1 - 0.08 12.5 0.0 0.16 11.5 0.0 1.4 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Rcd1 PF04078.13 EXF79735.1 - 1.2e-125 418.0 5.2 1.7e-125 417.6 5.2 1.2 1 0 0 1 1 1 1 Cell differentiation family, Rcd1-like TFIIA PF03153.13 EXF79735.1 - 0.00079 19.5 29.0 0.001 19.1 29.0 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Ndc1_Nup PF09531.10 EXF79735.1 - 0.0016 17.3 1.5 0.0016 17.2 1.5 1.2 1 0 0 1 1 1 1 Nucleoporin protein Ndc1-Nup RskA PF10099.9 EXF79735.1 - 0.002 18.4 6.1 0.0036 17.6 6.1 1.4 1 0 0 1 1 1 1 Anti-sigma-K factor rskA DDHD PF02862.17 EXF79735.1 - 0.016 15.4 4.4 0.022 14.9 4.4 1.3 1 0 0 1 1 1 0 DDHD domain Sin_N PF04801.13 EXF79735.1 - 0.059 12.6 15.2 0.074 12.3 15.2 1.1 1 0 0 1 1 1 0 Sin-like protein conserved region eIF-3_zeta PF05091.12 EXF79735.1 - 0.073 12.0 11.1 0.094 11.7 11.1 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) EPL1 PF10513.9 EXF79735.1 - 0.082 13.3 7.7 0.14 12.5 7.7 1.4 1 0 0 1 1 1 0 Enhancer of polycomb-like DDRGK PF09756.9 EXF79735.1 - 0.12 11.9 10.2 0.2 11.2 10.2 1.3 1 0 0 1 1 1 0 DDRGK domain SLC12 PF03522.15 EXF79735.1 - 0.13 11.3 7.5 0.18 10.8 7.5 1.2 1 0 0 1 1 1 0 Solute carrier family 12 Spt20 PF12090.8 EXF79735.1 - 0.16 11.5 34.0 0.35 10.4 34.0 1.6 1 0 0 1 1 1 0 Spt20 family PAT1 PF09770.9 EXF79735.1 - 0.23 9.7 21.8 0.29 9.4 21.8 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Connexin PF00029.19 EXF79735.1 - 0.28 10.9 6.1 0.5 10.1 6.1 1.4 1 0 0 1 1 1 0 Connexin HAUS6_N PF14661.6 EXF79735.1 - 0.36 10.4 13.8 3.4 7.2 11.5 2.2 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus Suf PF05843.14 EXF79735.1 - 0.37 10.7 14.7 0.55 10.2 14.7 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) UPF0524 PF15823.5 EXF79735.1 - 0.54 9.6 4.4 0.84 9.0 4.4 1.3 1 0 0 1 1 1 0 UPF0524 of C3orf70 Otopetrin PF03189.13 EXF79735.1 - 0.61 8.9 7.4 0.039 12.8 2.3 1.4 2 0 0 2 2 2 0 Otopetrin ALMT PF11744.8 EXF79735.1 - 0.71 8.6 8.1 1 8.1 8.1 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Velvet PF11754.8 EXF79735.1 - 0.74 9.7 12.2 1.1 9.2 12.2 1.3 1 0 0 1 1 1 0 Velvet factor AF-4 PF05110.13 EXF79735.1 - 0.79 7.7 18.8 1.1 7.3 18.8 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Pex14_N PF04695.13 EXF79735.1 - 0.85 10.3 21.5 1.5 9.4 21.5 1.4 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Band_3_cyto PF07565.13 EXF79735.1 - 1.2 8.9 13.1 0.45 10.3 9.8 1.9 2 0 0 2 2 2 0 Band 3 cytoplasmic domain FAM60A PF15396.6 EXF79735.1 - 1.2 9.1 8.1 1.9 8.5 8.1 1.3 1 0 0 1 1 1 0 Protein Family FAM60A RR_TM4-6 PF06459.12 EXF79735.1 - 1.4 8.7 10.9 2.1 8.1 10.9 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 TMEM51 PF15345.6 EXF79735.1 - 1.5 8.6 9.9 2.6 7.8 9.9 1.4 1 0 0 1 1 1 0 Transmembrane protein 51 Mcm10 PF09332.11 EXF79735.1 - 1.6 8.1 15.6 2.2 7.6 15.6 1.1 1 0 0 1 1 1 0 Mcm10 replication factor CTU2 PF10288.9 EXF79735.1 - 1.7 8.9 9.6 3.6 7.9 9.6 1.6 1 0 0 1 1 1 0 Cytoplasmic tRNA 2-thiolation protein 2 DUF3499 PF12005.8 EXF79735.1 - 2.2 8.9 9.6 4.4 7.9 9.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3499) DUF4175 PF13779.6 EXF79735.1 - 2.3 6.0 26.8 3.1 5.6 26.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Sec62 PF03839.16 EXF79735.1 - 2.4 7.6 6.2 3.6 7.0 6.2 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 Presenilin PF01080.17 EXF79735.1 - 2.8 6.6 16.6 4.3 6.0 16.6 1.2 1 0 0 1 1 1 0 Presenilin Med15 PF09606.10 EXF79735.1 - 3 6.4 32.8 3.9 6.0 32.8 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal RNA_pol_Rbc25 PF08292.12 EXF79735.1 - 3 8.1 7.3 6.1 7.1 7.3 1.5 1 0 0 1 1 1 0 RNA polymerase III subunit Rpc25 PepSY_TM PF03929.16 EXF79735.1 - 3.1 7.4 7.2 4.4 6.9 7.2 1.2 1 0 0 1 1 1 0 PepSY-associated TM region CPSF100_C PF13299.6 EXF79735.1 - 3.4 7.8 10.4 5.9 7.1 10.4 1.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Spore_coat_CotO PF14153.6 EXF79735.1 - 3.5 7.5 19.6 5.5 6.9 19.6 1.2 1 0 0 1 1 1 0 Spore coat protein CotO Roughex PF06020.11 EXF79735.1 - 3.9 6.5 11.1 5.7 5.9 11.1 1.2 1 0 0 1 1 1 0 Drosophila roughex protein DivIC PF04977.15 EXF79735.1 - 5.1 6.9 16.4 15 5.4 16.4 1.9 1 0 0 1 1 1 0 Septum formation initiator MMR1 PF08505.10 EXF79735.1 - 5.2 7.3 15.1 7.9 6.7 15.1 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Plasmodium_Vir PF05795.11 EXF79735.1 - 5.5 6.3 8.0 7.7 5.8 8.0 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein CLN3 PF02487.17 EXF79735.1 - 5.7 5.9 8.2 9.6 5.1 8.2 1.3 1 0 0 1 1 1 0 CLN3 protein Kei1 PF08552.11 EXF79735.1 - 7.8 6.3 11.8 15 5.4 11.8 1.4 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 DUF4407 PF14362.6 EXF79735.1 - 8.1 5.7 16.1 14 5.0 16.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) CCDC53 PF10152.9 EXF79735.1 - 8.8 6.7 14.9 20 5.6 14.9 1.5 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex UPF0560 PF10577.9 EXF79735.1 - 9.3 4.6 25.6 13 4.1 25.6 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 TERB2 PF15101.6 EXF79735.1 - 9.4 6.2 18.5 19 5.3 18.0 1.7 2 0 0 2 2 1 0 Telomere-associated protein TERB2 bZIP_1 PF00170.21 EXF79736.1 - 0.002 18.2 8.4 0.0033 17.5 8.4 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EXF79736.1 - 0.01 15.9 7.8 0.016 15.3 7.8 1.2 1 0 0 1 1 1 0 Basic region leucine zipper MAS20 PF02064.15 EXF79736.1 - 0.17 12.0 0.8 0.26 11.4 0.8 1.3 1 0 0 1 1 1 0 MAS20 protein import receptor CIA30 PF08547.12 EXF79737.1 - 1.9e-37 128.7 0.0 2.4e-37 128.4 0.0 1.1 1 0 0 1 1 1 1 Complex I intermediate-associated protein 30 (CIA30) CBM_11 PF03425.13 EXF79737.1 - 0.031 14.1 0.1 0.043 13.7 0.1 1.2 1 0 0 1 1 1 0 Carbohydrate binding domain (family 11) Homoserine_dh PF00742.19 EXF79738.1 - 2.1e-52 177.5 0.0 2.7e-52 177.2 0.0 1.1 1 0 0 1 1 1 1 Homoserine dehydrogenase NAD_binding_3 PF03447.16 EXF79738.1 - 2.3e-17 63.7 0.0 3.8e-17 63.0 0.0 1.4 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain IGPS PF00218.21 EXF79738.1 - 0.13 11.4 0.1 0.22 10.7 0.1 1.3 1 0 0 1 1 1 0 Indole-3-glycerol phosphate synthase DUF1295 PF06966.12 EXF79739.1 - 2.7e-40 138.4 1.1 1.3e-38 132.8 1.1 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF1295) Steroid_dh PF02544.16 EXF79739.1 - 0.0037 17.2 0.0 0.0095 15.9 0.0 1.7 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase GST_N PF02798.20 EXF79739.1 - 0.064 13.6 0.0 0.28 11.6 0.0 2.0 2 0 0 2 2 2 0 Glutathione S-transferase, N-terminal domain DUF3432 PF11914.8 EXF79739.1 - 6.3 7.1 7.5 14 6.0 0.2 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF3432) FBPase PF00316.20 EXF79740.1 - 1.4e-72 243.2 0.1 1.9e-72 242.7 0.1 1.2 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain PEX11 PF05648.14 EXF79741.1 - 5.4e-73 245.2 0.4 6e-73 245.0 0.4 1.0 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) RRM_1 PF00076.22 EXF79742.1 - 9.9e-24 83.0 0.0 7.6e-11 41.7 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EXF79742.1 - 0.012 15.4 0.0 0.53 10.2 0.0 2.1 2 0 0 2 2 2 0 Occluded RNA-recognition motif PXA PF02194.15 EXF79743.1 - 3.5e-54 183.5 0.6 1.6e-53 181.4 0.6 2.3 1 0 0 1 1 1 1 PXA domain Methyltransf_4 PF02390.17 EXF79743.1 - 1.8e-53 180.6 0.0 3.3e-53 179.7 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase Nexin_C PF08628.12 EXF79743.1 - 1.2e-30 106.4 0.1 5e-30 104.4 0.1 2.2 1 0 0 1 1 1 1 Sorting nexin C terminal PX PF00787.24 EXF79743.1 - 4.5e-21 74.9 0.5 1.5e-20 73.3 0.5 2.0 1 0 0 1 1 1 1 PX domain RGS PF00615.19 EXF79743.1 - 3.3e-12 46.7 0.0 1.2e-11 44.9 0.0 2.1 1 0 0 1 1 1 1 Regulator of G protein signaling domain Methyltransf_25 PF13649.6 EXF79743.1 - 0.0021 18.7 0.0 0.0072 17.0 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 EXF79743.1 - 0.0025 17.8 0.0 0.0074 16.3 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EXF79743.1 - 0.03 13.9 0.0 0.074 12.6 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_31 PF13847.6 EXF79743.1 - 0.039 13.7 0.0 0.11 12.2 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_12 PF08242.12 EXF79743.1 - 0.049 14.4 0.0 0.15 12.8 0.0 1.9 1 0 0 1 1 1 0 Methyltransferase domain PCMT PF01135.19 EXF79743.1 - 0.093 12.5 0.0 0.19 11.5 0.0 1.4 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) RrnaAD PF00398.20 EXF79743.1 - 0.13 11.3 0.0 0.6 9.1 0.0 2.0 2 0 0 2 2 2 0 Ribosomal RNA adenine dimethylase Cytochrom_B558a PF05038.13 EXF79744.1 - 0.12 12.0 0.1 0.13 11.8 0.1 1.1 1 0 0 1 1 1 0 Cytochrome Cytochrome b558 alpha-subunit CAP_N PF01213.19 EXF79744.1 - 0.15 11.6 3.0 0.18 11.2 3.0 1.1 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal DUF4078 PF13300.6 EXF79745.1 - 1.2e-28 99.3 19.2 1.2e-28 99.3 19.2 2.3 3 0 0 3 3 3 1 Domain of unknown function (DUF4078) Cwf_Cwc_15 PF04889.12 EXF79745.1 - 4.4 7.0 39.7 0.23 11.2 17.9 2.2 1 1 1 2 2 2 0 Cwf15/Cwc15 cell cycle control protein SRAP PF02586.14 EXF79746.1 - 0.1 12.1 0.2 0.4 10.2 0.0 1.9 2 0 0 2 2 2 0 SOS response associated peptidase (SRAP) DUF2207 PF09972.9 EXF79746.1 - 0.15 10.8 0.0 0.23 10.2 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Glyco_hydro_43 PF04616.14 EXF79747.1 - 4.1e-63 213.4 0.0 6.9e-63 212.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 GH43_C2 PF17851.1 EXF79747.1 - 1e-07 31.9 0.0 2e-07 30.9 0.0 1.5 1 1 0 1 1 1 1 Beta xylosidase C-terminal Concanavalin A-like domain Peptidase_M14 PF00246.24 EXF79748.1 - 5.8e-15 55.9 0.0 9.1e-15 55.2 0.0 1.3 1 0 0 1 1 1 1 Zinc carboxypeptidase AstE_AspA PF04952.14 EXF79748.1 - 0.02 14.0 0.0 0.043 12.9 0.0 1.6 1 0 0 1 1 1 0 Succinylglutamate desuccinylase / Aspartoacylase family CorA PF01544.18 EXF79749.1 - 0.0034 16.8 0.1 0.0084 15.5 0.1 1.6 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein DUF4232 PF14016.6 EXF79750.1 - 0.1 12.7 0.3 0.3 11.2 0.3 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF4232) Peptidase_M35 PF02102.15 EXF79751.1 - 3.6e-57 193.9 16.4 4.3e-57 193.6 16.4 1.0 1 0 0 1 1 1 1 Deuterolysin metalloprotease (M35) family Aspzincin_M35 PF14521.6 EXF79751.1 - 4.7e-39 134.2 1.2 4.7e-39 134.2 1.2 1.9 1 1 1 2 2 2 1 Lysine-specific metallo-endopeptidase DUF1120 PF06551.12 EXF79751.1 - 0.04 14.1 5.9 1.9 8.7 2.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1120) Asn_synthase PF00733.21 EXF79753.1 - 1.5e-66 225.5 0.0 2.4e-66 224.8 0.0 1.3 1 0 0 1 1 1 1 Asparagine synthase GATase_7 PF13537.6 EXF79753.1 - 1.6e-35 121.7 0.0 3.4e-35 120.6 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 EXF79753.1 - 6.2e-32 110.6 0.0 5.9e-31 107.4 0.0 2.4 3 0 0 3 3 3 1 Glutamine amidotransferase domain DUF3700 PF12481.8 EXF79753.1 - 3e-06 26.8 0.0 8.1e-06 25.4 0.0 1.6 2 0 0 2 2 2 1 Aluminium induced protein BORCS8 PF10167.9 EXF79753.1 - 0.06 13.3 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 BLOC-1-related complex sub-unit 8 NAD_synthase PF02540.17 EXF79753.1 - 0.11 11.6 0.0 0.18 10.9 0.0 1.3 1 0 0 1 1 1 0 NAD synthase DUF4632 PF15451.6 EXF79753.1 - 0.13 12.4 0.0 0.29 11.2 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4632) PS_Dcarbxylase PF02666.15 EXF79754.1 - 5.9e-49 166.3 0.0 8.8e-49 165.8 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase Cytochrom_B561 PF03188.16 EXF79755.1 - 0.26 11.4 7.6 0.57 10.3 7.6 1.6 1 0 0 1 1 1 0 Eukaryotic cytochrome b561 DUF4079 PF13301.6 EXF79755.1 - 1.2 9.3 17.0 1.9 8.7 2.8 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF4079) FA_desaturase PF00487.24 EXF79755.1 - 7.4 6.3 18.2 11 5.7 6.0 2.3 1 1 1 2 2 2 0 Fatty acid desaturase MFS_2 PF13347.6 EXF79756.1 - 1.2e-10 40.6 7.7 1.2e-10 40.6 7.7 2.8 3 0 0 3 3 3 2 MFS/sugar transport protein Na_H_Exchanger PF00999.21 EXF79757.1 - 4.1e-72 243.1 39.4 5.4e-72 242.7 39.4 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family PepSY_TM PF03929.16 EXF79757.1 - 5.2 6.6 7.7 0.27 10.9 1.8 1.8 2 0 0 2 2 2 0 PepSY-associated TM region Myb_DNA-bind_6 PF13921.6 EXF79758.1 - 1.8e-15 56.9 0.4 5.9e-15 55.3 0.4 2.0 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 EXF79758.1 - 4.9e-05 23.4 0.2 0.00012 22.2 0.2 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain MAPEG PF01124.18 EXF79759.1 - 1.5e-14 54.1 1.3 1.7e-14 53.8 1.3 1.1 1 0 0 1 1 1 1 MAPEG family GH131_N PF18271.1 EXF79761.1 - 3.7e-65 220.2 5.5 4.3e-65 220.0 5.5 1.0 1 0 0 1 1 1 1 Glycoside hydrolase 131 catalytic N-terminal domain Polysacc_lyase PF14099.6 EXF79761.1 - 0.05 13.4 5.7 0.14 12.0 5.6 1.7 1 1 0 1 1 1 0 Polysaccharide lyase SNF5 PF04855.12 EXF79763.1 - 1.9e-65 220.9 0.0 1.9e-64 217.7 0.0 2.1 1 1 0 1 1 1 1 SNF5 / SMARCB1 / INI1 INO80_Ies4 PF08193.11 EXF79763.1 - 0.0024 17.9 1.7 0.0024 17.9 1.7 2.8 3 0 0 3 3 3 2 INO80 complex subunit Ies4 Peptidase_M24 PF00557.24 EXF79764.1 - 2.9e-09 36.9 0.0 3.8e-09 36.5 0.0 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 PHD PF00628.29 EXF79765.1 - 3.1e-12 46.2 18.8 2.7e-07 30.4 8.6 2.5 2 0 0 2 2 2 2 PHD-finger zf-HC5HC2H PF13771.6 EXF79765.1 - 0.0046 17.2 5.0 0.032 14.5 1.3 2.4 2 0 0 2 2 2 1 PHD-like zinc-binding domain Zf_RING PF16744.5 EXF79765.1 - 0.17 12.0 11.7 0.75 9.9 0.5 2.7 2 0 0 2 2 2 0 KIAA1045 RING finger zf-PHD-like PF15446.6 EXF79765.1 - 3.4 7.3 10.9 5.6 6.5 3.8 2.5 2 0 0 2 2 2 0 PHD/FYVE-zinc-finger like domain PUF PF00806.19 EXF79766.1 - 1.1e-25 87.9 0.0 0.00027 20.5 0.0 5.5 5 0 0 5 5 5 5 Pumilio-family RNA binding repeat RRM_1 PF00076.22 EXF79766.1 - 9.3e-13 47.8 0.0 2.3e-12 46.5 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) AAA_2 PF07724.14 EXF79767.1 - 8.8e-48 162.6 0.0 4.3e-46 157.2 0.0 3.1 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 EXF79767.1 - 1.5e-32 111.6 14.7 8.8e-32 109.1 2.7 3.8 4 0 0 4 4 3 2 AAA lid domain AAA PF00004.29 EXF79767.1 - 1.6e-27 96.5 0.0 1.9e-14 54.2 0.0 2.9 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.9 EXF79767.1 - 5.1e-24 84.1 2.6 1.3e-23 82.9 0.5 2.9 2 0 0 2 2 2 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.14 EXF79767.1 - 3.6e-16 59.4 0.0 4e-10 39.8 0.0 3.2 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EXF79767.1 - 9.2e-13 48.6 0.0 5.7e-05 23.4 0.0 4.4 2 1 1 3 3 3 2 AAA domain AAA_16 PF13191.6 EXF79767.1 - 3.2e-12 47.2 13.7 7.8e-07 29.6 0.1 5.7 4 3 0 5 5 4 2 AAA ATPase domain Sigma54_activat PF00158.26 EXF79767.1 - 8.6e-10 38.6 0.0 1.2e-06 28.3 0.0 2.8 2 1 0 2 2 2 2 Sigma-54 interaction domain Clp_N PF02861.20 EXF79767.1 - 1.5e-07 31.5 2.6 0.00019 21.5 0.3 4.0 3 0 0 3 3 3 1 Clp amino terminal domain, pathogenicity island component AAA_14 PF13173.6 EXF79767.1 - 1.9e-06 28.0 0.0 0.12 12.4 0.0 3.0 2 0 0 2 2 2 2 AAA domain AAA_7 PF12775.7 EXF79767.1 - 2e-06 27.5 0.0 0.0073 15.8 0.0 2.6 2 0 0 2 2 2 2 P-loop containing dynein motor region Mg_chelatase PF01078.21 EXF79767.1 - 2.9e-06 26.8 0.0 0.085 12.2 0.1 3.7 2 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 EXF79767.1 - 2.9e-06 27.1 0.0 0.065 13.0 0.0 2.8 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_33 PF13671.6 EXF79767.1 - 3.8e-06 27.1 1.0 0.24 11.5 0.0 4.0 2 1 0 2 2 2 2 AAA domain ATPase_2 PF01637.18 EXF79767.1 - 5.3e-06 26.5 6.7 0.03 14.2 0.2 4.9 3 2 1 5 5 5 1 ATPase domain predominantly from Archaea AAA_18 PF13238.6 EXF79767.1 - 8.9e-06 26.3 3.7 0.11 13.0 0.0 4.3 3 1 0 3 3 3 2 AAA domain AAA_3 PF07726.11 EXF79767.1 - 2.5e-05 24.1 0.1 0.88 9.4 0.0 4.2 4 0 0 4 4 4 1 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 EXF79767.1 - 2.9e-05 24.4 0.0 0.37 11.2 0.0 2.9 3 0 0 3 3 2 2 RNA helicase AAA_28 PF13521.6 EXF79767.1 - 3.6e-05 24.1 0.0 0.45 10.7 0.0 3.5 2 0 0 2 2 2 2 AAA domain AAA_30 PF13604.6 EXF79767.1 - 0.00013 21.7 0.0 1.1 8.9 0.0 3.2 2 0 0 2 2 2 2 AAA domain TsaE PF02367.17 EXF79767.1 - 0.00014 21.9 0.0 0.34 10.9 0.0 2.5 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE RuvB_N PF05496.12 EXF79767.1 - 0.00016 21.5 1.7 2.1 8.0 0.6 4.3 3 1 0 3 3 3 1 Holliday junction DNA helicase RuvB P-loop domain AAA_24 PF13479.6 EXF79767.1 - 0.00018 21.3 0.3 0.54 9.9 0.0 3.4 4 0 0 4 4 2 2 AAA domain RsgA_GTPase PF03193.16 EXF79767.1 - 0.00037 20.4 0.0 0.39 10.6 0.0 2.9 2 0 0 2 2 2 1 RsgA GTPase T2SSE PF00437.20 EXF79767.1 - 0.00044 19.4 0.0 0.0061 15.7 0.0 2.6 2 0 0 2 2 2 1 Type II/IV secretion system protein ABC_tran PF00005.27 EXF79767.1 - 0.00048 20.6 0.1 0.64 10.5 0.0 3.2 3 0 0 3 3 2 1 ABC transporter NACHT PF05729.12 EXF79767.1 - 0.0015 18.4 0.0 0.21 11.5 0.0 3.0 3 0 0 3 3 2 1 NACHT domain AAA_19 PF13245.6 EXF79767.1 - 0.0022 18.3 3.9 0.18 12.2 0.1 4.0 6 1 0 6 6 2 1 AAA domain ResIII PF04851.15 EXF79767.1 - 0.0023 18.0 0.0 0.34 10.9 0.0 3.5 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit Torsin PF06309.11 EXF79767.1 - 0.0024 18.0 0.0 0.013 15.6 0.0 2.1 2 0 0 2 2 2 1 Torsin Roc PF08477.13 EXF79767.1 - 0.0034 17.6 0.0 2.1 8.6 0.0 2.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.6 EXF79767.1 - 0.0038 16.9 0.0 4.3 7.2 0.0 2.7 2 0 0 2 2 2 0 P-loop containing region of AAA domain Zeta_toxin PF06414.12 EXF79767.1 - 0.0048 16.2 0.0 0.54 9.5 0.0 2.7 2 0 0 2 2 2 1 Zeta toxin Rad17 PF03215.15 EXF79767.1 - 0.0048 16.9 0.1 4.1 7.3 0.0 3.0 3 0 0 3 3 2 0 Rad17 P-loop domain NTPase_1 PF03266.15 EXF79767.1 - 0.0057 16.6 0.2 0.22 11.4 0.0 3.2 4 0 0 4 4 2 1 NTPase SRP54 PF00448.22 EXF79767.1 - 0.018 14.7 0.0 4.6 6.8 0.0 2.7 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain DUF815 PF05673.13 EXF79767.1 - 0.021 14.0 0.0 2.3 7.3 0.0 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF815) AAA_15 PF13175.6 EXF79767.1 - 0.033 13.9 0.9 22 4.6 0.2 3.5 4 0 0 4 4 3 0 AAA ATPase domain AAA_25 PF13481.6 EXF79767.1 - 0.037 13.6 2.0 3.5 7.2 0.0 3.5 3 0 0 3 3 3 0 AAA domain ATP_bind_1 PF03029.17 EXF79767.1 - 0.059 13.2 0.0 6.9 6.4 0.0 2.6 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein KTI12 PF08433.10 EXF79767.1 - 0.069 12.6 3.7 10 5.5 0.0 3.9 4 0 0 4 4 4 0 Chromatin associated protein KTI12 PduV-EutP PF10662.9 EXF79767.1 - 0.098 12.4 0.0 6.9 6.4 0.0 2.7 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Cytidylate_kin PF02224.18 EXF79767.1 - 0.11 12.2 7.3 36 4.0 0.0 4.3 4 1 1 5 5 4 0 Cytidylate kinase AAA_23 PF13476.6 EXF79767.1 - 0.12 12.8 15.8 0.36 11.3 0.0 4.3 4 1 0 4 4 2 0 AAA domain AAA_6 PF12774.7 EXF79767.1 - 0.13 11.2 0.3 5.7 5.8 0.0 3.0 3 0 0 3 3 3 0 Hydrolytic ATP binding site of dynein motor region CorA PF01544.18 EXF79767.1 - 0.82 8.9 3.7 2.3 7.4 3.7 1.8 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Cob_adeno_trans PF01923.18 EXF79767.1 - 1.2 9.3 10.0 0.17 12.0 3.4 2.8 3 0 0 3 3 3 0 Cobalamin adenosyltransferase CbiA PF01656.23 EXF79767.1 - 1.2 9.2 3.8 37 4.4 0.1 3.5 3 2 1 4 4 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain Cep57_CLD_2 PF14197.6 EXF79767.1 - 2.3 8.4 13.3 0.2 11.8 7.7 2.3 2 0 0 2 2 1 0 Centrosome localisation domain of PPC89 V_ATPase_I PF01496.19 EXF79767.1 - 5.1 4.9 6.0 11 3.8 5.8 1.6 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family Mhr1 PF12829.7 EXF79768.1 - 5.5e-35 119.3 0.1 8.8e-35 118.7 0.1 1.3 1 0 0 1 1 1 1 Transcriptional regulation of mitochondrial recombination Sulfotransfer_3 PF13469.6 EXF79769.1 - 1.3e-08 35.5 0.1 7.7e-08 33.0 0.1 2.0 1 1 0 1 1 1 1 Sulfotransferase family GPI-anchored PF10342.9 EXF79770.1 - 1.5e-23 83.4 2.0 1.5e-23 83.4 2.0 2.7 2 1 1 3 3 3 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family DUF4448 PF14610.6 EXF79770.1 - 0.0005 19.9 0.3 0.00071 19.4 0.3 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF4448) ABM PF03992.16 EXF79771.1 - 0.00095 19.2 0.0 0.067 13.3 0.0 2.5 2 1 0 2 2 2 1 Antibiotic biosynthesis monooxygenase DUF3764 PF12594.8 EXF79771.1 - 0.052 13.6 0.0 0.1 12.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3764) DUF1330 PF07045.11 EXF79771.1 - 0.12 12.7 0.1 0.25 11.7 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1330) KH_1 PF00013.29 EXF79772.1 - 7.3e-43 144.2 6.6 3.1e-18 65.3 0.7 3.3 3 0 0 3 3 3 3 KH domain KH_2 PF07650.17 EXF79772.1 - 2.3e-12 46.6 4.6 0.0052 16.6 0.4 3.3 3 0 0 3 3 3 3 KH domain KH_4 PF13083.6 EXF79772.1 - 1.3e-06 28.1 0.8 0.33 10.8 0.2 3.4 3 0 0 3 3 3 2 KH domain MOEP19 PF16005.5 EXF79772.1 - 3.9e-05 23.6 0.0 0.011 15.7 0.0 2.8 3 0 0 3 3 3 1 KH-like RNA-binding domain KH_5 PF13184.6 EXF79772.1 - 0.0015 18.6 8.7 0.33 11.1 0.3 3.4 3 0 0 3 3 3 2 NusA-like KH domain CENP-K PF11802.8 EXF79773.1 - 8.5e-10 38.6 7.3 0.00036 20.2 0.0 2.6 2 1 0 2 2 2 2 Centromere-associated protein K DinB_2 PF12867.7 EXF79773.1 - 0.018 15.6 3.3 2.5 8.6 0.2 2.7 3 0 0 3 3 3 0 DinB superfamily FapA PF03961.13 EXF79773.1 - 0.11 11.1 4.9 2.1 6.8 0.1 2.3 2 0 0 2 2 2 0 Flagellar Assembly Protein A Atg14 PF10186.9 EXF79773.1 - 0.81 8.7 11.3 3.8 6.5 5.6 2.2 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4404 PF14357.6 EXF79773.1 - 9.3 7.0 12.9 6.9 7.4 3.4 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4404) Phos_pyr_kin PF08543.12 EXF79774.1 - 3.3e-11 43.0 0.0 6.9e-11 42.0 0.0 1.5 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase PfkB PF00294.24 EXF79774.1 - 8.7e-07 28.5 2.2 1.3e-06 27.9 0.0 2.3 3 0 0 3 3 3 1 pfkB family carbohydrate kinase PCNA_N PF00705.18 EXF79775.1 - 1.2e-53 180.1 3.3 1.2e-53 180.1 3.3 1.9 2 1 0 2 2 2 1 Proliferating cell nuclear antigen, N-terminal domain PCNA_C PF02747.15 EXF79775.1 - 6.7e-50 168.6 0.0 1.2e-49 167.7 0.0 1.4 1 0 0 1 1 1 1 Proliferating cell nuclear antigen, C-terminal domain Rad9 PF04139.13 EXF79775.1 - 2e-09 37.2 0.0 2.5e-09 36.9 0.0 1.1 1 0 0 1 1 1 1 Rad9 Rad1 PF02144.16 EXF79775.1 - 4.7e-06 25.9 0.3 0.00011 21.4 0.3 2.0 1 1 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 Hus1 PF04005.12 EXF79775.1 - 0.0011 18.2 0.2 0.0063 15.7 0.0 2.0 2 1 0 2 2 2 1 Hus1-like protein DNA_pol3_beta_3 PF02768.15 EXF79775.1 - 0.044 13.6 0.1 0.14 12.0 0.0 1.9 2 1 0 2 2 2 0 DNA polymerase III beta subunit, C-terminal domain AMA-1 PF02430.15 EXF79775.1 - 0.055 12.4 0.0 0.09 11.7 0.0 1.3 1 0 0 1 1 1 0 Apical membrane antigen 1 Vezatin PF12632.7 EXF79776.1 - 6.5e-78 261.9 0.0 1.2e-77 261.0 0.0 1.4 1 0 0 1 1 1 1 Mysoin-binding motif of peroxisomes DUF4231 PF14015.6 EXF79776.1 - 0.07 13.6 2.3 0.29 11.6 1.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) Rab5ip PF07019.12 EXF79777.1 - 5e-29 100.7 9.7 6e-29 100.5 9.7 1.1 1 0 0 1 1 1 1 Rab5-interacting protein (Rab5ip) GTP_EFTU PF00009.27 EXF79778.1 - 1.3e-09 37.9 0.0 4.6e-09 36.1 0.0 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 EXF79778.1 - 0.0045 17.4 0.1 0.012 16.1 0.1 1.7 1 0 0 1 1 1 1 AAA ATPase domain DUF5546 PF17700.1 EXF79778.1 - 0.054 13.9 0.1 0.19 12.1 0.1 1.9 1 0 0 1 1 1 0 Family of unknown function (DUF5546) T2SSE PF00437.20 EXF79778.1 - 0.09 11.8 0.5 0.18 10.8 0.5 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_29 PF13555.6 EXF79778.1 - 0.1 12.4 0.9 0.26 11.1 0.9 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain HA2 PF04408.23 EXF79781.1 - 1.9e-17 63.5 0.3 9.5e-17 61.3 0.0 2.3 3 0 0 3 3 3 1 Helicase associated domain (HA2) Helicase_C PF00271.31 EXF79781.1 - 6e-12 45.9 0.0 2.3e-11 44.0 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.16 EXF79781.1 - 8e-11 42.2 0.0 3.1e-10 40.3 0.0 2.0 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.29 EXF79781.1 - 9e-08 32.1 0.0 2.4e-07 30.7 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase T2SSE PF00437.20 EXF79781.1 - 0.0013 17.8 0.0 0.0058 15.7 0.0 1.7 1 1 0 2 2 2 1 Type II/IV secretion system protein AAA_22 PF13401.6 EXF79781.1 - 0.0016 18.7 0.2 0.0043 17.3 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 EXF79781.1 - 0.0046 16.7 0.0 0.011 15.4 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_tran PF00005.27 EXF79781.1 - 0.026 15.1 0.0 0.1 13.1 0.0 2.0 1 0 0 1 1 1 0 ABC transporter AAA_23 PF13476.6 EXF79781.1 - 0.042 14.3 0.0 3.3 8.1 0.0 2.6 2 0 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.18 EXF79781.1 - 0.052 12.9 0.0 0.45 9.8 0.0 2.1 2 0 0 2 2 2 0 FtsK/SpoIIIE family Clostridium_P47 PF06597.11 EXF79781.1 - 0.092 11.5 0.0 0.15 10.7 0.0 1.2 1 0 0 1 1 1 0 Clostridium P-47 protein AAA_7 PF12775.7 EXF79781.1 - 0.14 11.7 0.0 0.26 10.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region Patatin PF01734.22 EXF79782.1 - 2.8e-26 93.0 0.0 5.5e-26 92.0 0.0 1.5 1 0 0 1 1 1 1 Patatin-like phospholipase TPR_12 PF13424.6 EXF79782.1 - 1.3e-18 67.0 9.8 1.4e-08 34.9 0.6 4.8 3 1 1 5 5 5 4 Tetratricopeptide repeat Complex1_LYR_2 PF13233.6 EXF79782.1 - 1.7e-17 63.9 0.0 1.6e-16 60.8 0.0 2.6 2 0 0 2 2 2 1 Complex1_LYR-like TPR_10 PF13374.6 EXF79782.1 - 5e-13 48.4 10.5 0.00033 20.4 0.1 6.0 5 0 0 5 5 5 3 Tetratricopeptide repeat NB-ARC PF00931.22 EXF79782.1 - 4.1e-12 45.8 0.0 8.6e-12 44.8 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain Complex1_LYR PF05347.15 EXF79782.1 - 1.1e-09 38.1 0.4 9e-09 35.3 0.0 2.7 2 0 0 2 2 2 1 Complex 1 protein (LYR family) AAA_16 PF13191.6 EXF79782.1 - 7e-05 23.3 0.0 0.00041 20.8 0.0 2.2 2 0 0 2 2 2 1 AAA ATPase domain PPR PF01535.20 EXF79782.1 - 0.0056 16.8 0.1 15 6.1 0.0 4.0 3 0 0 3 3 3 0 PPR repeat TPR_4 PF07721.14 EXF79782.1 - 0.01 16.4 15.0 17 6.4 0.1 6.7 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_MalT PF17874.1 EXF79782.1 - 0.017 14.5 4.8 0.0079 15.6 2.4 1.7 2 0 0 2 2 2 0 MalT-like TPR region TPR_14 PF13428.6 EXF79782.1 - 0.04 14.7 10.7 9 7.4 0.1 5.9 6 0 0 6 6 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 EXF79782.1 - 0.047 13.8 6.9 4.4 7.6 0.0 5.0 6 0 0 6 6 5 0 Tetratricopeptide repeat TniB PF05621.11 EXF79782.1 - 0.053 12.9 0.0 0.11 11.9 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein NAD_binding_8 PF13450.6 EXF79783.1 - 8e-09 35.6 0.0 2.4e-08 34.1 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 EXF79783.1 - 0.00041 19.6 0.0 0.21 10.7 0.0 3.5 3 1 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.14 EXF79783.1 - 0.00066 19.0 0.0 0.13 11.4 0.0 3.4 3 1 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 EXF79783.1 - 0.0015 17.0 0.3 0.025 13.0 0.0 2.3 2 1 0 2 2 2 1 Flavin-binding monooxygenase-like NAD_binding_9 PF13454.6 EXF79783.1 - 0.0028 17.7 0.1 0.11 12.5 0.0 2.9 3 0 0 3 3 3 1 FAD-NAD(P)-binding Pyr_redox_3 PF13738.6 EXF79783.1 - 0.035 13.4 0.1 0.2 10.9 0.1 2.3 2 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase GPI-anchored PF10342.9 EXF79786.1 - 7.4e-17 61.9 3.8 7.4e-17 61.9 3.8 2.9 2 1 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family RIFIN PF02009.16 EXF79786.1 - 1.2 8.9 6.2 1.4 8.8 6.2 1.1 1 0 0 1 1 1 0 Rifin Macoilin PF09726.9 EXF79786.1 - 5.3 5.5 15.1 6.3 5.2 15.1 1.1 1 0 0 1 1 1 0 Macoilin family SpoIIE PF07228.12 EXF79787.1 - 3.6e-09 36.8 0.3 1.6e-08 34.7 0.2 1.9 1 1 1 2 2 2 1 Stage II sporulation protein E (SpoIIE) PP2C PF00481.21 EXF79787.1 - 1.1e-06 28.5 1.7 0.013 15.1 0.1 2.8 3 0 0 3 3 3 2 Protein phosphatase 2C PP2C_2 PF13672.6 EXF79787.1 - 4.2e-06 26.5 0.8 1e-05 25.3 0.8 1.6 1 1 0 1 1 1 1 Protein phosphatase 2C Fer2_3 PF13085.6 EXF79788.1 - 7.6e-33 112.8 0.0 1.2e-32 112.1 0.0 1.3 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer4_17 PF13534.6 EXF79788.1 - 1.4e-08 35.2 6.1 1.4e-08 35.2 6.1 2.2 3 0 0 3 3 3 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 EXF79788.1 - 6.2e-08 32.6 3.0 6.2e-08 32.6 3.0 2.0 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_8 PF13183.6 EXF79788.1 - 1.1e-07 32.2 7.0 1.1e-07 32.2 7.0 2.2 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_7 PF12838.7 EXF79788.1 - 0.0011 19.5 4.1 0.0011 19.5 4.1 2.4 2 1 0 2 2 2 1 4Fe-4S dicluster domain Fer2 PF00111.27 EXF79788.1 - 0.0011 18.8 2.1 0.0027 17.6 0.2 2.3 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Fer4_9 PF13187.6 EXF79788.1 - 0.44 10.7 13.0 1.3 9.2 10.0 2.8 2 1 2 4 4 4 0 4Fe-4S dicluster domain FAD_binding_2 PF00890.24 EXF79789.1 - 2.8e-123 412.1 4.6 3.5e-123 411.8 4.6 1.1 1 0 0 1 1 1 1 FAD binding domain Succ_DH_flav_C PF02910.20 EXF79789.1 - 7.2e-43 145.6 0.1 1.1e-42 145.0 0.1 1.3 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term Pyr_redox_2 PF07992.14 EXF79789.1 - 5.5e-06 25.8 1.2 0.0022 17.3 0.6 2.8 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EXF79789.1 - 5.9e-05 22.3 1.4 0.019 14.0 2.1 2.2 2 0 0 2 2 2 2 Glucose inhibited division protein A Thi4 PF01946.17 EXF79789.1 - 8.5e-05 21.9 0.2 0.035 13.3 0.1 2.4 2 0 0 2 2 2 2 Thi4 family FAD_binding_3 PF01494.19 EXF79789.1 - 0.0019 17.5 0.8 0.0066 15.7 0.1 2.0 2 0 0 2 2 2 1 FAD binding domain DAO PF01266.24 EXF79789.1 - 0.12 11.9 1.5 0.23 11.0 1.5 1.5 1 1 0 1 1 1 0 FAD dependent oxidoreductase HI0933_like PF03486.14 EXF79789.1 - 0.13 10.9 0.9 0.35 9.5 0.4 1.9 2 0 0 2 2 2 0 HI0933-like protein AIRC PF00731.20 EXF79791.1 - 5.3e-61 204.5 1.1 1.2e-60 203.4 0.6 1.9 2 0 0 2 2 2 1 AIR carboxylase ATP-grasp PF02222.22 EXF79791.1 - 5.6e-50 169.3 0.0 1.1e-49 168.3 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain PurK_C PF17769.1 EXF79791.1 - 5.9e-15 54.7 0.0 1.3e-14 53.6 0.0 1.6 1 0 0 1 1 1 1 Phosphoribosylaminoimidazole carboxylase C-terminal domain Dala_Dala_lig_C PF07478.13 EXF79791.1 - 4.4e-06 26.4 0.0 1e-05 25.2 0.0 1.6 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus PrpR_N PF06506.11 EXF79791.1 - 0.0061 16.2 0.1 0.095 12.3 0.0 2.4 2 0 0 2 2 2 1 Propionate catabolism activator XdhC_C PF13478.6 EXF79791.1 - 0.045 14.2 0.2 7.1 7.2 0.0 2.6 2 1 0 2 2 2 0 XdhC Rossmann domain ATP-grasp_4 PF13535.6 EXF79791.1 - 0.07 12.7 0.0 0.89 9.1 0.0 2.3 1 1 0 1 1 1 0 ATP-grasp domain Dus PF01207.17 EXF79792.1 - 2.1e-33 115.7 0.0 1.1e-29 103.5 0.0 2.4 2 1 0 2 2 2 2 Dihydrouridine synthase (Dus) Cyclin_N PF00134.23 EXF79793.1 - 2.7e-07 30.4 0.5 0.0011 18.7 0.7 2.5 2 0 0 2 2 2 2 Cyclin, N-terminal domain Glyco_hydro_88 PF07470.13 EXF79793.1 - 0.012 14.8 0.4 0.017 14.2 0.4 1.2 1 0 0 1 1 1 0 Glycosyl Hydrolase Family 88 TFIIB PF00382.19 EXF79793.1 - 0.12 12.5 0.2 0.22 11.6 0.2 1.4 1 0 0 1 1 1 0 Transcription factor TFIIB repeat Proteasome PF00227.26 EXF79794.1 - 1.8e-46 158.0 0.1 2.1e-46 157.8 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Peptidase_M22 PF00814.25 EXF79795.1 - 6.6e-45 153.9 0.5 1.5e-16 60.9 0.3 4.1 3 1 1 4 4 4 4 Glycoprotease family YycC PF14174.6 EXF79795.1 - 0.14 12.0 0.0 0.3 10.9 0.0 1.5 1 0 0 1 1 1 0 YycC-like protein Glyco_transf_34 PF05637.12 EXF79797.1 - 6.3e-64 216.0 1.3 8.2e-64 215.6 1.3 1.1 1 0 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family Glyco_hydro_16 PF00722.21 EXF79798.1 - 3.4e-08 33.2 0.1 6.2e-08 32.3 0.1 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 SNF2_N PF00176.23 EXF79799.1 - 1.3e-35 122.7 0.2 3.3e-33 114.9 0.0 2.2 2 0 0 2 2 2 2 SNF2 family N-terminal domain Helicase_C PF00271.31 EXF79799.1 - 1.2e-07 32.1 0.1 4e-07 30.4 0.1 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EXF79799.1 - 1.1e-05 25.3 0.1 0.00011 22.1 0.0 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 EXF79799.1 - 0.00028 20.9 0.0 0.19 11.8 0.0 2.8 3 0 0 3 3 3 2 Type III restriction enzyme, res subunit LRR_4 PF12799.7 EXF79801.1 - 0.0029 18.0 3.0 1.4 9.4 0.0 3.4 2 1 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EXF79801.1 - 0.0039 16.9 4.9 0.79 9.5 1.2 3.1 3 0 0 3 3 3 2 Leucine rich repeat F-box-like PF12937.7 EXF79801.1 - 0.023 14.6 0.2 0.066 13.1 0.2 1.8 1 0 0 1 1 1 0 F-box-like TauD PF02668.16 EXF79802.1 - 5e-38 131.4 0.3 6.8e-38 131.0 0.3 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF971 PF06155.12 EXF79802.1 - 0.018 15.7 0.0 0.04 14.6 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF971) adh_short_C2 PF13561.6 EXF79803.1 - 9e-60 202.1 3.5 2.1e-59 200.9 3.5 1.6 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF79803.1 - 1.1e-34 119.6 4.5 7.2e-34 117.0 4.5 1.9 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EXF79803.1 - 1.4e-06 28.4 0.9 5.2e-06 26.5 0.9 1.9 1 1 0 1 1 1 1 KR domain 3HCDH_N PF02737.18 EXF79803.1 - 0.021 14.7 1.0 0.062 13.2 0.1 2.0 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 EXF79803.1 - 0.029 13.8 0.0 0.06 12.7 0.0 1.5 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Metallophos PF00149.28 EXF79804.1 - 1.2e-37 130.4 0.1 3.2e-37 129.0 0.0 1.7 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Cyclase PF04199.13 EXF79805.1 - 2e-06 28.1 0.0 3.1e-06 27.5 0.0 1.3 1 0 0 1 1 1 1 Putative cyclase zf-H2C2_2 PF13465.6 EXF79807.1 - 5.2e-06 26.6 1.3 5.2e-06 26.6 1.3 3.3 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_6 PF13912.6 EXF79807.1 - 5.4e-06 26.3 0.7 0.011 15.7 0.0 2.3 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 EXF79807.1 - 9.7e-06 25.8 0.5 9.7e-06 25.8 0.5 3.8 3 1 0 3 3 3 1 Zinc finger, C2H2 type FOXP-CC PF16159.5 EXF79807.1 - 1e-05 26.1 6.7 0.25 12.0 0.0 3.5 2 1 1 3 3 3 2 FOXP coiled-coil domain zf-C2H2_4 PF13894.6 EXF79807.1 - 0.001 19.7 8.2 0.0039 17.9 0.4 3.2 3 0 0 3 3 3 1 C2H2-type zinc finger DUF5595 PF18077.1 EXF79807.1 - 0.018 15.1 0.3 0.052 13.6 0.3 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF5595) zf-H2C2_5 PF13909.6 EXF79807.1 - 0.27 11.0 2.8 0.62 9.9 0.1 2.4 2 0 0 2 2 2 0 C2H2-type zinc-finger domain zf-C2H2_jaz PF12171.8 EXF79807.1 - 0.61 10.4 4.0 2.6 8.5 0.3 3.1 3 1 0 3 3 3 0 Zinc-finger double-stranded RNA-binding Sina PF03145.16 EXF79807.1 - 1.2 9.0 8.3 3.7 7.4 1.0 2.8 1 1 2 3 3 3 0 Seven in absentia protein family LRR_6 PF13516.6 EXF79808.1 - 6.5e-09 35.2 5.1 0.13 12.4 0.0 6.3 7 0 0 7 7 7 2 Leucine Rich repeat LRR_4 PF12799.7 EXF79808.1 - 2.9e-08 33.9 18.0 0.039 14.4 0.2 5.6 6 1 0 6 6 6 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EXF79808.1 - 0.00054 20.1 0.2 14 6.7 0.1 5.4 5 0 0 5 5 5 1 Leucine Rich Repeat LRR_8 PF13855.6 EXF79808.1 - 0.0011 18.6 10.0 1.7 8.5 0.2 5.1 4 1 0 4 4 4 3 Leucine rich repeat Radial_spoke PF04712.12 EXF79808.1 - 5.1 5.9 12.6 39 3.0 12.6 2.0 2 0 0 2 2 2 0 Radial spokehead-like protein DUF2567 PF10821.8 EXF79809.1 - 0.04 14.0 5.0 2.4 8.2 2.9 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2567) DHHC PF01529.20 EXF79809.1 - 0.22 11.6 4.0 0.37 10.9 4.0 1.4 1 0 0 1 1 1 0 DHHC palmitoyltransferase DUF4044 PF13253.6 EXF79809.1 - 6.8 6.3 6.2 0.56 9.8 0.9 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4044) Glyco_hydro_18 PF00704.28 EXF79810.1 - 1.1e-86 291.5 5.9 1.3e-86 291.2 5.9 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Fungal_trans PF04082.18 EXF79811.1 - 1.4e-15 57.0 0.1 3.2e-15 55.9 0.1 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain MGC-24 PF05283.11 EXF79811.1 - 9.5 6.7 6.5 2.2 8.7 2.8 1.8 2 0 0 2 2 2 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin Alpha-amylase PF00128.24 EXF79812.1 - 2.9e-54 184.9 0.0 4.2e-54 184.4 0.0 1.2 1 0 0 1 1 1 1 Alpha amylase, catalytic domain DUF1966 PF09260.11 EXF79812.1 - 2e-19 69.6 0.0 3.5e-19 68.9 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1966) NuA4 PF09340.10 EXF79814.1 - 5.3e-24 83.9 1.5 7.8e-24 83.4 0.1 1.8 2 0 0 2 2 2 1 Histone acetyltransferase subunit NuA4 NUDE_C PF04880.13 EXF79814.1 - 5.2 7.5 10.3 9.5 6.7 9.8 1.7 1 1 0 1 1 1 0 NUDE protein, C-terminal conserved region Peptidase_S9 PF00326.21 EXF79815.1 - 2e-53 181.0 0.0 4.1e-53 180.0 0.0 1.5 1 0 0 1 1 1 1 Prolyl oligopeptidase family PD40 PF07676.12 EXF79815.1 - 0.00025 20.9 0.0 0.034 14.1 0.0 2.7 2 0 0 2 2 2 2 WD40-like Beta Propeller Repeat IKI3 PF04762.12 EXF79815.1 - 0.19 9.7 0.0 0.28 9.1 0.0 1.1 1 0 0 1 1 1 0 IKI3 family Bromo_TP PF07524.13 EXF79816.1 - 2.2e-06 27.5 0.0 4.3e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 Bromodomain associated Ribosomal_60s PF00428.19 EXF79816.1 - 0.16 12.6 8.3 1.1 9.9 2.8 2.9 3 0 0 3 3 3 0 60s Acidic ribosomal protein RMI1_N PF08585.12 EXF79816.1 - 0.29 10.9 2.9 0.47 10.2 2.9 1.3 1 0 0 1 1 1 0 RecQ mediated genome instability protein TPT PF03151.16 EXF79817.1 - 1.8e-15 57.0 16.4 4.4e-15 55.8 16.4 1.6 1 1 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 EXF79817.1 - 0.0067 16.6 34.7 0.1 12.8 18.7 2.6 2 1 0 2 2 2 2 EamA-like transporter family SHOCT PF09851.9 EXF79817.1 - 0.14 11.9 0.0 0.29 10.9 0.0 1.5 1 0 0 1 1 1 0 Short C-terminal domain TFIIA PF03153.13 EXF79817.1 - 0.15 12.0 10.0 0.24 11.4 10.0 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Glyco_hydro_15 PF00723.21 EXF79818.1 - 1.1e-50 172.8 0.0 7e-46 156.9 0.0 2.1 1 1 1 2 2 2 2 Glycosyl hydrolases family 15 IL10 PF00726.17 EXF79818.1 - 0.1 12.1 0.1 0.84 9.1 0.1 2.0 2 0 0 2 2 2 0 Interleukin 10 RRM_1 PF00076.22 EXF79819.1 - 3.6e-17 61.9 0.0 6.1e-17 61.2 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Cytotoxic PF09000.10 EXF79819.1 - 0.067 13.5 1.4 0.12 12.8 0.0 2.0 2 0 0 2 2 2 0 Cytotoxic OB_RNB PF08206.11 EXF79819.1 - 0.15 11.7 0.2 0.29 10.8 0.2 1.4 1 0 0 1 1 1 0 Ribonuclease B OB domain 6PGD PF00393.19 EXF79821.1 - 2.5e-128 427.5 0.0 3.5e-128 427.0 0.0 1.2 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 EXF79821.1 - 1.9e-49 167.8 0.0 2.9e-49 167.3 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase DNA_pol3_beta PF00712.19 EXF79821.1 - 0.013 15.6 0.0 0.034 14.3 0.0 1.6 1 0 0 1 1 1 0 DNA polymerase III beta subunit, N-terminal domain PGK PF00162.19 EXF79821.1 - 0.042 12.8 0.0 0.068 12.1 0.0 1.3 1 0 0 1 1 1 0 Phosphoglycerate kinase NAD_binding_11 PF14833.6 EXF79821.1 - 0.044 14.0 0.0 0.16 12.2 0.0 2.0 1 0 0 1 1 1 0 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase 3HCDH_N PF02737.18 EXF79821.1 - 0.24 11.3 0.6 1.2 9.0 0.1 2.0 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain SWI-SNF_Ssr4 PF08549.10 EXF79822.1 - 1e-288 960.0 13.8 1.8e-288 959.2 13.8 1.4 1 1 0 1 1 1 1 Fungal domain of unknown function (DUF1750) Vir_act_alpha_C PF10400.9 EXF79822.1 - 1.4 9.6 5.1 23 5.8 1.7 2.6 2 0 0 2 2 2 0 Virulence activator alpha C-term GPI-anchored PF10342.9 EXF79823.1 - 2e-06 28.5 0.0 4.6e-06 27.3 0.0 1.6 1 0 0 1 1 1 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Glutaredoxin PF00462.24 EXF79824.1 - 7.3e-19 67.7 0.0 5.1e-18 65.0 0.0 2.2 2 0 0 2 2 2 1 Glutaredoxin Thioredoxin PF00085.20 EXF79824.1 - 2.1e-13 50.1 0.0 4.9e-13 49.0 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 EXF79824.1 - 0.016 15.6 0.0 5.4 7.4 0.0 2.8 1 1 1 2 2 2 0 Thioredoxin-like HyaE PF07449.11 EXF79824.1 - 0.033 14.2 0.0 0.13 12.2 0.0 2.0 2 1 0 2 2 2 0 Hydrogenase-1 expression protein HyaE Thioredoxin_3 PF13192.6 EXF79824.1 - 0.086 12.9 0.0 0.49 10.5 0.0 2.2 2 1 0 2 2 2 0 Thioredoxin domain SH3_9 PF14604.6 EXF79825.1 - 1.4e-28 98.5 4.4 3.4e-14 52.4 0.5 2.5 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.28 EXF79825.1 - 2.8e-26 90.9 4.6 1.2e-12 47.3 0.3 2.4 2 0 0 2 2 2 2 SH3 domain SH3_2 PF07653.17 EXF79825.1 - 2.6e-17 62.2 0.0 4.2e-07 29.5 0.0 3.0 3 0 0 3 3 3 2 Variant SH3 domain Cofilin_ADF PF00241.20 EXF79825.1 - 8.8e-15 54.6 0.0 1.7e-14 53.7 0.0 1.4 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein DUF3873 PF12989.7 EXF79825.1 - 0.066 13.6 0.0 2.1 8.8 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function, B. Theta Gene description (DUF3873) NPP1 PF05630.11 EXF79826.1 - 1e-51 175.9 0.0 1.3e-51 175.5 0.0 1.1 1 0 0 1 1 1 1 Necrosis inducing protein (NPP1) adh_short PF00106.25 EXF79827.1 - 3.5e-05 23.4 0.1 5e-05 22.9 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EXF79827.1 - 0.0082 16.1 0.2 0.013 15.5 0.2 1.4 1 0 0 1 1 1 1 KR domain Shikimate_DH PF01488.20 EXF79827.1 - 0.034 14.2 0.2 0.076 13.1 0.2 1.6 1 1 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase adh_short_C2 PF13561.6 EXF79827.1 - 0.053 13.1 0.0 0.086 12.4 0.0 1.3 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase p450 PF00067.22 EXF79828.1 - 6.7e-26 91.0 0.0 4.9e-25 88.2 0.0 1.9 1 1 0 1 1 1 1 Cytochrome P450 DUF521 PF04412.13 EXF79829.1 - 1.5e-92 310.4 0.0 2.9e-92 309.5 0.0 1.4 2 0 0 2 2 2 1 Protein of unknown function (DUF521) DUF126 PF01989.16 EXF79829.1 - 8.8e-29 99.1 0.2 1.7e-28 98.2 0.2 1.5 1 0 0 1 1 1 1 Aconitase X swivel domain Fungal_lectin PF07938.12 EXF79830.1 - 9.1e-07 28.5 3.9 1.3e-06 28.0 3.9 1.2 1 0 0 1 1 1 1 Fungal fucose-specific lectin Lipase_GDSL_2 PF13472.6 EXF79832.1 - 9.9e-13 48.9 0.0 1.4e-12 48.4 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EXF79832.1 - 5.1e-07 29.9 0.0 3e-06 27.3 0.0 1.8 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase MFS_1 PF07690.16 EXF79833.1 - 1e-29 103.6 24.5 3.6e-29 101.8 24.1 1.8 2 0 0 2 2 2 1 Major Facilitator Superfamily RseC_MucC PF04246.12 EXF79833.1 - 0.0013 18.7 1.6 1.1 9.3 0.4 3.1 1 1 0 2 2 2 2 Positive regulator of sigma(E), RseC/MucC Rhomboid PF01694.22 EXF79833.1 - 0.92 9.5 13.4 0.078 13.0 5.5 3.0 2 1 1 3 3 3 0 Rhomboid family MRJP PF03022.16 EXF79834.1 - 6.5e-12 45.4 0.0 9.1e-12 44.9 0.0 1.2 1 0 0 1 1 1 1 Major royal jelly protein SGL PF08450.12 EXF79834.1 - 0.0062 16.1 0.9 0.55 9.8 0.1 2.6 2 1 0 2 2 2 2 SMP-30/Gluconolactonase/LRE-like region NHL PF01436.21 EXF79834.1 - 0.017 15.1 0.9 1.7 8.9 0.1 2.9 2 0 0 2 2 2 0 NHL repeat LVIVD PF08309.11 EXF79834.1 - 0.057 12.8 0.5 0.18 11.2 0.5 1.9 1 0 0 1 1 1 0 LVIVD repeat MIT_LIKE_ACTX PF17556.2 EXF79834.1 - 0.2 12.3 0.0 0.43 11.2 0.0 1.5 1 0 0 1 1 1 0 MIT-like atracotoxin family SNF PF00209.18 EXF79835.1 - 4.7e-80 269.7 31.4 4.7e-80 269.7 31.4 2.6 2 1 0 2 2 2 1 Sodium:neurotransmitter symporter family AtuA PF07287.11 EXF79836.1 - 5.5e-125 416.7 0.1 6.5e-125 416.5 0.1 1.1 1 0 0 1 1 1 1 Acyclic terpene utilisation family protein AtuA Hemerythrin PF01814.23 EXF79837.1 - 1.6e-06 28.7 0.6 2.4e-06 28.2 0.6 1.3 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain DUF2383 PF09537.10 EXF79837.1 - 0.00078 19.8 0.0 0.0013 19.0 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF2383) SelP_N PF04592.14 EXF79838.1 - 0.47 9.8 8.7 0.71 9.2 8.7 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Glyco_hydro_61 PF03443.14 EXF79839.1 - 3e-58 197.2 0.2 3.5e-58 196.9 0.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 Sortilin-Vps10 PF15902.5 EXF79841.1 - 8.3e-20 71.0 3.0 2.1e-06 26.8 0.0 6.2 3 2 3 7 7 7 5 Sortilin, neurotensin receptor 3, BNR PF02012.20 EXF79841.1 - 1.7e-09 36.2 29.4 0.2 11.7 0.1 9.5 9 0 0 9 9 9 6 BNR/Asp-box repeat BNR_6 PF15899.5 EXF79841.1 - 0.0021 17.9 8.8 3.3 8.0 0.2 6.5 8 0 0 8 8 8 2 BNR-Asp box repeat BNR_2 PF13088.6 EXF79841.1 - 0.015 14.6 9.1 1.9 7.7 0.6 5.4 3 2 2 5 5 5 0 BNR repeat-like domain DUF2452 PF10504.9 EXF79841.1 - 0.21 11.0 0.0 0.38 10.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2452) CHB_HEX_C PF03174.13 EXF79841.1 - 0.23 11.5 0.9 18 5.4 0.0 4.0 4 0 0 4 4 4 0 Chitobiase/beta-hexosaminidase C-terminal domain GMC_oxred_N PF00732.19 EXF79842.1 - 2e-60 204.7 0.0 2.5e-60 204.3 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EXF79842.1 - 2.3e-38 131.9 0.2 4.3e-38 131.1 0.2 1.5 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.24 EXF79842.1 - 1.8e-05 24.1 0.0 0.031 13.3 0.1 2.2 2 0 0 2 2 2 2 FAD binding domain Thi4 PF01946.17 EXF79842.1 - 7.4e-05 22.1 0.2 0.00024 20.4 0.1 1.8 2 0 0 2 2 2 1 Thi4 family Lycopene_cycl PF05834.12 EXF79842.1 - 0.00012 21.3 0.1 0.00018 20.7 0.1 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_3 PF13738.6 EXF79842.1 - 0.00025 20.4 0.1 0.098 11.9 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EXF79842.1 - 0.00034 20.0 0.3 0.002 17.4 0.1 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EXF79842.1 - 0.00046 20.4 0.1 0.0012 19.0 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EXF79842.1 - 0.0011 18.6 1.5 0.0082 15.8 1.5 2.1 1 1 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 EXF79842.1 - 0.049 12.3 0.1 0.087 11.5 0.1 1.3 1 0 0 1 1 1 0 HI0933-like protein NAD_binding_9 PF13454.6 EXF79842.1 - 0.078 13.0 0.1 0.22 11.5 0.1 1.7 1 0 0 1 1 1 0 FAD-NAD(P)-binding Trp_halogenase PF04820.14 EXF79842.1 - 0.11 11.3 0.4 0.18 10.6 0.2 1.4 2 0 0 2 2 2 0 Tryptophan halogenase NAD_binding_8 PF13450.6 EXF79843.1 - 4.2e-12 46.1 0.2 9.2e-12 45.0 0.2 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 EXF79843.1 - 6.6e-07 29.0 0.0 1.4e-06 27.9 0.0 1.5 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase FAD_oxidored PF12831.7 EXF79843.1 - 0.00015 21.3 0.0 0.0002 20.8 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EXF79843.1 - 0.00021 20.5 0.4 0.00035 19.8 0.4 1.3 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 EXF79843.1 - 0.00021 21.0 0.5 0.00045 19.9 0.5 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 EXF79843.1 - 0.00069 18.9 0.1 0.0011 18.2 0.1 1.2 1 0 0 1 1 1 1 Thi4 family HI0933_like PF03486.14 EXF79843.1 - 0.0007 18.4 0.2 0.0011 17.8 0.2 1.2 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_2 PF07992.14 EXF79843.1 - 0.0092 15.2 0.1 0.015 14.5 0.1 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EXF79843.1 - 0.084 12.1 0.1 0.16 11.2 0.1 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EXF79843.1 - 0.09 13.3 0.1 0.25 11.9 0.1 1.8 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EXF79843.1 - 0.15 11.2 0.4 0.21 10.6 0.4 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A Tannase PF07519.11 EXF79845.1 - 4.5e-115 385.2 0.7 5.7e-115 384.9 0.7 1.1 1 0 0 1 1 1 1 Tannase and feruloyl esterase Hydrolase_4 PF12146.8 EXF79845.1 - 0.00093 18.5 0.0 0.07 12.4 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EXF79845.1 - 0.025 14.2 0.0 0.14 11.8 0.0 2.0 1 1 0 1 1 1 0 alpha/beta hydrolase fold p450 PF00067.22 EXF79846.1 - 3.5e-24 85.4 0.0 4.3e-20 71.9 0.0 2.1 2 0 0 2 2 2 2 Cytochrome P450 Esterase_phd PF10503.9 EXF79847.1 - 6.1e-22 78.2 1.7 1.1e-21 77.3 1.7 1.4 1 0 0 1 1 1 1 Esterase PHB depolymerase CBM_1 PF00734.18 EXF79847.1 - 6.1e-15 54.9 8.6 2.7e-14 52.8 8.6 2.2 1 0 0 1 1 1 1 Fungal cellulose binding domain Peptidase_S9 PF00326.21 EXF79847.1 - 1.9e-10 40.6 4.0 3.1e-10 39.9 4.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Esterase PF00756.20 EXF79847.1 - 0.025 14.2 0.2 0.041 13.5 0.2 1.3 1 0 0 1 1 1 0 Putative esterase Aa_trans PF01490.18 EXF79848.1 - 4.8e-83 279.2 18.4 5.7e-83 278.9 18.4 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein CAAD PF14159.6 EXF79848.1 - 9.1 6.2 8.1 0.64 9.9 0.9 2.8 3 0 0 3 3 3 0 CAAD domains of cyanobacterial aminoacyl-tRNA synthetase DUF2256 PF10013.9 EXF79849.1 - 0.031 14.4 5.7 1.6 8.9 1.7 2.6 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2256) Vps36-NZF-N PF16988.5 EXF79849.1 - 0.08 12.4 0.3 0.18 11.3 0.3 1.6 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain DUF1075 PF06388.11 EXF79849.1 - 0.26 11.3 2.7 0.67 10.0 2.7 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1075) mRNA_cap_C PF03919.15 EXF79851.1 - 0.025 15.2 0.0 0.044 14.4 0.0 1.4 1 0 0 1 1 1 0 mRNA capping enzyme, C-terminal domain An_peroxidase PF03098.15 EXF79852.1 - 4.2e-31 108.1 0.0 3.5e-22 78.7 0.0 3.3 1 1 1 2 2 2 2 Animal haem peroxidase p450 PF00067.22 EXF79852.1 - 1.9e-07 30.2 0.0 6.9e-07 28.4 0.0 1.8 2 0 0 2 2 2 1 Cytochrome P450 DUF433 PF04255.14 EXF79852.1 - 0.14 12.0 0.1 21 5.1 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF433) DUF2235 PF09994.9 EXF79853.1 - 4.4e-89 298.6 0.1 6.6e-89 298.1 0.1 1.3 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) Amidase PF01425.21 EXF79854.1 - 1.8e-21 76.6 7.2 4.1e-19 68.9 7.2 2.2 1 1 0 1 1 1 1 Amidase Tautomerase_3 PF14832.6 EXF79854.1 - 3.4e-08 33.8 0.0 1e-07 32.3 0.0 1.7 2 0 0 2 2 2 1 Putative oxalocrotonate tautomerase enzyme p450 PF00067.22 EXF79855.1 - 6.4e-41 140.6 0.0 7.8e-41 140.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 COesterase PF00135.28 EXF79857.1 - 6.9e-83 279.3 0.1 8.8e-83 278.9 0.1 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EXF79857.1 - 3.9e-07 30.1 0.2 4.4e-06 26.7 0.2 2.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EXF79857.1 - 0.00017 21.1 3.6 0.00047 19.7 3.6 1.6 1 1 0 1 1 1 1 Prolyl oligopeptidase family GspH PF12019.8 EXF79857.1 - 0.082 13.3 1.9 14 6.2 0.4 3.0 3 0 0 3 3 3 0 Type II transport protein GspH VHL PF01847.16 EXF79858.1 - 0.08 12.9 0.0 0.26 11.2 0.0 1.8 2 0 0 2 2 2 0 VHL beta domain ADH_zinc_N PF00107.26 EXF79859.1 - 1.4e-27 96.2 0.1 2.3e-27 95.6 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EXF79859.1 - 1e-22 81.6 0.0 2.4e-22 80.4 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EXF79859.1 - 1.6e-08 34.4 0.1 4.4e-08 33.0 0.1 1.8 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain AlaDh_PNT_C PF01262.21 EXF79859.1 - 0.036 13.3 0.2 0.062 12.6 0.2 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain ADH_N_2 PF16884.5 EXF79859.1 - 0.037 13.9 0.0 0.081 12.8 0.0 1.5 1 0 0 1 1 1 0 N-terminal domain of oxidoreductase IPI_T4 PF11634.8 EXF79859.1 - 0.088 12.8 0.3 1.1 9.3 0.1 2.3 2 0 0 2 2 2 0 Nuclease inhibitor from bacteriophage T4 FAD_binding_2 PF00890.24 EXF79860.1 - 6.7e-94 315.3 0.8 8.5e-94 315.0 0.8 1.0 1 0 0 1 1 1 1 FAD binding domain FAD_binding_3 PF01494.19 EXF79860.1 - 9e-07 28.5 0.1 3e-06 26.7 0.0 1.8 2 0 0 2 2 2 1 FAD binding domain NAD_binding_8 PF13450.6 EXF79860.1 - 6.1e-06 26.4 0.1 1.9e-05 24.8 0.1 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EXF79860.1 - 7.9e-05 22.4 4.2 0.00048 19.8 4.2 2.0 1 1 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.22 EXF79860.1 - 0.00032 19.9 0.1 0.00032 19.9 0.1 1.7 2 0 0 2 2 2 1 Glucose inhibited division protein A HI0933_like PF03486.14 EXF79860.1 - 0.00042 19.1 5.0 0.006 15.3 0.2 2.4 2 0 0 2 2 2 2 HI0933-like protein Pyr_redox_2 PF07992.14 EXF79860.1 - 0.00051 19.4 0.5 0.0045 16.3 0.1 2.5 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EXF79860.1 - 0.00058 19.3 0.0 0.001 18.5 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 EXF79860.1 - 0.0025 17.1 0.2 0.0069 15.6 0.1 1.7 2 0 0 2 2 2 1 Thi4 family Pyr_redox_3 PF13738.6 EXF79860.1 - 0.027 13.8 0.3 0.066 12.5 0.2 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EXF79860.1 - 0.059 13.9 0.4 1.2 9.7 0.2 2.9 3 0 0 3 3 2 0 Pyridine nucleotide-disulphide oxidoreductase DUF3273 PF11677.8 EXF79861.1 - 0.029 13.7 7.3 0.026 13.9 3.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3273) Fungal_trans PF04082.18 EXF79862.1 - 7.8e-18 64.4 0.1 1.5e-17 63.5 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Dala_Dala_lig_C PF07478.13 EXF79862.1 - 2.4e-06 27.2 0.0 3.9e-06 26.5 0.0 1.3 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus Zn_clus PF00172.18 EXF79862.1 - 3.2e-06 27.1 7.4 6.1e-06 26.3 7.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CPSase_L_D2 PF02786.17 EXF79862.1 - 0.02 14.4 0.0 0.031 13.8 0.0 1.3 1 0 0 1 1 1 0 Carbamoyl-phosphate synthase L chain, ATP binding domain ATP-grasp_4 PF13535.6 EXF79862.1 - 0.021 14.4 0.0 0.066 12.8 0.0 1.9 1 1 0 1 1 1 0 ATP-grasp domain GARS_A PF01071.19 EXF79862.1 - 0.022 14.5 0.0 0.035 13.9 0.0 1.2 1 0 0 1 1 1 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ATP-grasp_3 PF02655.14 EXF79862.1 - 0.027 14.5 0.0 0.049 13.7 0.0 1.4 1 0 0 1 1 1 0 ATP-grasp domain RimK PF08443.11 EXF79862.1 - 0.062 12.9 0.0 0.1 12.2 0.0 1.3 1 0 0 1 1 1 0 RimK-like ATP-grasp domain SGL PF08450.12 EXF79865.1 - 8.9e-28 97.5 0.1 1.2e-27 97.1 0.1 1.2 1 0 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Arylesterase PF01731.20 EXF79865.1 - 6.6e-05 23.0 0.0 0.00022 21.4 0.0 1.9 2 0 0 2 2 2 1 Arylesterase Str_synth PF03088.16 EXF79865.1 - 0.00017 21.7 0.0 0.00043 20.4 0.0 1.8 1 1 0 1 1 1 1 Strictosidine synthase NHL PF01436.21 EXF79865.1 - 0.065 13.3 0.4 2.5 8.3 0.0 3.5 3 0 0 3 3 3 0 NHL repeat Hexapep_2 PF14602.6 EXF79866.1 - 4.7e-14 51.8 9.4 4.2e-10 39.2 3.6 3.2 3 0 0 3 3 3 2 Hexapeptide repeat of succinyl-transferase Hexapep PF00132.24 EXF79866.1 - 7.2e-14 50.9 9.5 2.6e-09 36.5 3.8 3.3 3 0 0 3 3 3 3 Bacterial transferase hexapeptide (six repeats) Mac PF12464.8 EXF79866.1 - 3.4e-09 36.8 0.1 5.5e-09 36.1 0.1 1.3 1 0 0 1 1 1 1 Maltose acetyltransferase Tmemb_170 PF10190.9 EXF79867.1 - 3.2e-25 88.5 14.8 3.8e-25 88.3 14.8 1.1 1 0 0 1 1 1 1 Putative transmembrane protein 170 DUF4383 PF14325.6 EXF79867.1 - 0.15 12.4 10.2 0.49 10.7 10.2 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4383) bZIP_1 PF00170.21 EXF79870.1 - 7e-06 26.0 6.6 7e-06 26.0 6.6 1.7 2 0 0 2 2 2 1 bZIP transcription factor ComFB PF10719.9 EXF79870.1 - 0.23 11.6 1.5 0.44 10.7 1.5 1.3 1 0 0 1 1 1 0 Late competence development protein ComFB DUF5595 PF18077.1 EXF79870.1 - 0.26 11.4 1.0 0.35 11.0 0.1 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF5595) bZIP_2 PF07716.15 EXF79870.1 - 2.3 8.4 10.1 0.65 10.1 6.4 2.0 2 0 0 2 2 2 0 Basic region leucine zipper Chitin_bind_1 PF00187.19 EXF79875.1 - 2.9e-15 56.4 39.1 9.3e-14 51.6 13.9 2.4 2 0 0 2 2 2 2 Chitin recognition protein LysM PF01476.20 EXF79876.1 - 4.1e-12 46.0 0.1 2.2e-06 27.6 0.0 5.7 7 0 0 7 7 7 2 LysM domain CxC6 PF18721.1 EXF79876.1 - 0.51 10.6 3.2 0.68 10.2 0.1 2.8 3 0 0 3 3 3 0 CxC6 like cysteine cluster associated with KDZ transposases Peptidase_M20 PF01546.28 EXF79878.1 - 3.9e-29 101.8 0.1 5.1e-29 101.5 0.1 1.1 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EXF79878.1 - 0.0035 17.2 0.0 0.0086 16.0 0.0 1.6 1 1 0 1 1 1 1 Peptidase dimerisation domain MFS_1 PF07690.16 EXF79879.1 - 9.5e-38 130.0 28.7 9.5e-38 130.0 28.7 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily Fungal_trans PF04082.18 EXF79880.1 - 3.1e-13 49.4 0.9 5.1e-13 48.7 0.9 1.5 1 1 0 1 1 1 1 Fungal specific transcription factor domain bZIP_1 PF00170.21 EXF79882.1 - 0.00014 21.9 6.9 0.00025 21.1 6.9 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EXF79882.1 - 1.2 9.3 9.0 2 8.6 9.0 1.4 1 0 0 1 1 1 0 Basic region leucine zipper Lactonase PF10282.9 EXF79883.1 - 0.00012 21.4 0.0 0.0022 17.3 0.0 2.3 1 1 0 2 2 2 1 Lactonase, 7-bladed beta-propeller DUF1815 PF08844.10 EXF79883.1 - 0.19 11.8 0.1 0.19 11.8 0.1 2.0 2 1 1 3 3 3 0 Domain of unknown function (DUF1815) Aa_trans PF01490.18 EXF79884.1 - 1.1e-28 100.2 35.3 1.2e-28 100.0 35.3 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein SLATT_1 PF18181.1 EXF79884.1 - 2.8 7.9 10.9 7.1 6.6 2.8 3.0 3 0 0 3 3 3 0 SMODS and SLOG-associating 2TM effector domain 1 Polysacc_deac_1 PF01522.21 EXF79885.1 - 1.2e-18 67.2 0.0 2.3e-18 66.3 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide deacetylase DUF2334 PF10096.9 EXF79885.1 - 1.5e-05 24.8 0.0 2.6e-05 24.0 0.0 1.5 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2334) DUF2194 PF09960.9 EXF79885.1 - 0.14 10.5 0.0 0.17 10.2 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein conserved in bacteria (DUF2194) ADH_N PF08240.12 EXF79886.1 - 4.8e-22 77.9 0.5 1.4e-21 76.4 0.1 2.0 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EXF79886.1 - 1.3e-17 64.0 0.0 2.5e-17 63.1 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 EXF79886.1 - 0.0025 17.2 0.0 0.0041 16.5 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain XdhC_C PF13478.6 EXF79886.1 - 0.0099 16.4 0.2 0.034 14.6 0.0 2.0 3 0 0 3 3 3 1 XdhC Rossmann domain ThiF PF00899.21 EXF79886.1 - 0.073 12.4 0.5 0.49 9.7 0.3 2.0 2 0 0 2 2 2 0 ThiF family TGS PF02824.21 EXF79886.1 - 0.11 12.6 0.0 0.19 11.8 0.0 1.4 1 0 0 1 1 1 0 TGS domain Ribosomal_L18p PF00861.22 EXF79886.1 - 0.15 12.4 0.0 0.33 11.3 0.0 1.5 1 0 0 1 1 1 0 Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast Amidase PF01425.21 EXF79887.1 - 8.7e-86 288.6 0.1 1.1e-85 288.3 0.1 1.1 1 0 0 1 1 1 1 Amidase MSP1b PF03429.13 EXF79887.1 - 0.031 12.4 0.0 0.048 11.8 0.0 1.2 1 0 0 1 1 1 0 Major surface protein 1B Zn_clus PF00172.18 EXF79888.1 - 6.7e-07 29.3 10.0 1.2e-06 28.5 10.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EXF79888.1 - 0.00022 20.2 0.1 0.00033 19.6 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain adh_short_C2 PF13561.6 EXF79889.1 - 4e-58 196.7 0.3 5e-58 196.4 0.3 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF79889.1 - 1.2e-40 139.0 0.2 1.6e-40 138.7 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EXF79889.1 - 6.1e-07 29.5 0.1 1.2e-06 28.6 0.1 1.5 1 1 0 1 1 1 1 KR domain ThiF PF00899.21 EXF79889.1 - 0.00079 18.9 1.8 0.025 14.0 1.0 2.8 2 1 1 3 3 3 1 ThiF family DUF5448 PF17526.2 EXF79889.1 - 0.016 15.4 0.0 0.2 11.8 0.0 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5448) Sulfotransfer_4 PF17784.1 EXF79890.1 - 4.4e-58 196.6 0.0 7.9e-58 195.8 0.0 1.4 1 0 0 1 1 1 1 Sulfotransferase domain Fungal_trans PF04082.18 EXF79890.1 - 8.9e-15 54.4 0.1 2.4e-14 53.0 0.1 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain Sulfotransfer_3 PF13469.6 EXF79890.1 - 0.0038 17.6 5.6 0.51 10.7 0.0 4.1 3 1 1 4 4 4 2 Sulfotransferase family UPF0547 PF10571.9 EXF79890.1 - 0.17 12.0 1.0 0.4 10.8 1.0 1.6 1 0 0 1 1 1 0 Uncharacterised protein family UPF0547 zf-C2H2 PF00096.26 EXF79890.1 - 0.42 11.2 6.2 0.39 11.3 0.3 2.9 2 0 0 2 2 2 0 Zinc finger, C2H2 type Cofilin_ADF PF00241.20 EXF79891.1 - 2.3e-39 133.9 0.0 3.7e-23 81.6 0.0 2.1 2 0 0 2 2 2 2 Cofilin/tropomyosin-type actin-binding protein Mito_carr PF00153.27 EXF79892.1 - 3.1e-60 200.1 1.6 9e-22 76.8 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein WD40 PF00400.32 EXF79893.1 - 2.7e-45 151.4 14.6 1e-06 29.3 0.4 8.6 8 0 0 8 8 8 7 WD domain, G-beta repeat F-box-like PF12937.7 EXF79893.1 - 5.5e-13 48.6 0.1 1e-12 47.7 0.1 1.5 1 0 0 1 1 1 1 F-box-like Nup160 PF11715.8 EXF79893.1 - 6.8e-13 48.1 1.9 0.014 14.1 0.1 4.2 2 2 1 4 4 4 4 Nucleoporin Nup120/160 F-box PF00646.33 EXF79893.1 - 1.2e-09 37.7 0.0 3e-09 36.5 0.0 1.6 1 0 0 1 1 1 1 F-box domain ANAPC4_WD40 PF12894.7 EXF79893.1 - 4.3e-09 36.5 0.2 0.079 13.3 0.0 6.0 2 2 5 7 7 7 2 Anaphase-promoting complex subunit 4 WD40 domain F-box_4 PF15966.5 EXF79893.1 - 6.8e-05 22.7 0.0 0.0002 21.2 0.0 1.8 1 0 0 1 1 1 1 F-box WD40_like PF17005.5 EXF79893.1 - 0.00078 18.9 0.1 0.53 9.5 0.0 2.6 2 1 1 3 3 3 2 WD40-like domain BBS2_Mid PF14783.6 EXF79893.1 - 0.0025 17.8 0.0 1.1 9.4 0.0 3.8 3 1 1 4 4 4 1 Ciliary BBSome complex subunit 2, middle region BRK PF07533.16 EXF79893.1 - 0.041 13.5 0.1 30 4.4 0.0 3.8 4 0 0 4 4 4 0 BRK domain PALB2_WD40 PF16756.5 EXF79893.1 - 1.3 7.9 3.2 20 4.0 0.1 3.3 2 2 0 3 3 3 0 Partner and localizer of BRCA2 WD40 domain His_Phos_2 PF00328.22 EXF79894.1 - 8.3e-07 28.7 1.9 0.00012 21.5 0.1 2.5 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 2) Glyco_hydro_61 PF03443.14 EXF79895.1 - 3.1e-63 213.4 0.2 5.6e-63 212.6 0.2 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 Tyrosinase PF00264.20 EXF79897.1 - 8.2e-24 85.1 2.6 1.8e-23 84.0 2.1 1.7 1 1 1 2 2 2 1 Common central domain of tyrosinase DUF3144 PF11342.8 EXF79898.1 - 0.072 13.4 0.1 0.089 13.1 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3144) SET PF00856.28 EXF79900.1 - 1.3e-08 35.4 1.8 2.9e-08 34.3 0.3 2.4 2 1 0 2 2 2 1 SET domain DUF4438 PF14505.6 EXF79900.1 - 0.1 11.6 0.0 0.16 10.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4438) RhoGAP-FF1 PF16512.5 EXF79900.1 - 0.16 12.7 0.9 1.1 10.0 0.1 2.4 2 0 0 2 2 2 0 p190-A and -B Rho GAPs FF domain HypA PF01155.19 EXF79900.1 - 0.71 9.9 4.4 0.16 12.0 0.2 2.0 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Ribosomal_L14 PF00238.19 EXF79901.1 - 2.4e-45 153.5 3.1 2.9e-45 153.3 3.1 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e RNA_POL_M_15KD PF02150.16 EXF79902.1 - 7.9e-12 44.9 3.0 7.9e-12 44.9 3.0 2.2 2 0 0 2 2 2 1 RNA polymerases M/15 Kd subunit GFA PF04828.14 EXF79902.1 - 0.71 10.3 7.2 1.2 9.5 0.1 2.3 1 1 1 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme DZR PF12773.7 EXF79902.1 - 3.6 7.7 11.9 7.1e+02 0.3 11.9 2.8 1 1 0 1 1 1 0 Double zinc ribbon Nudix_N_2 PF14803.6 EXF79902.1 - 7.6 6.5 13.5 0.17 11.8 1.6 3.1 3 0 0 3 3 3 0 Nudix N-terminal Rotamase PF00639.21 EXF79903.1 - 3.8e-23 82.3 0.0 5.4e-23 81.8 0.0 1.2 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_3 PF13616.6 EXF79903.1 - 8.6e-16 58.5 0.0 1.2e-15 58.1 0.0 1.2 1 0 0 1 1 1 1 PPIC-type PPIASE domain WW PF00397.26 EXF79903.1 - 1.5e-08 34.6 0.6 1.5e-08 34.6 0.6 1.7 2 0 0 2 2 2 1 WW domain Rotamase_2 PF13145.6 EXF79903.1 - 7.9e-05 23.5 0.0 0.00011 23.1 0.0 1.3 1 1 0 1 1 1 1 PPIC-type PPIASE domain WW_1 PF18507.1 EXF79903.1 - 0.00074 19.1 0.6 0.0013 18.4 0.6 1.4 1 0 0 1 1 1 1 WW domain LrgB PF04172.16 EXF79904.1 - 2.7e-22 79.4 13.9 8.6e-17 61.4 2.8 2.7 3 0 0 3 3 3 2 LrgB-like family GT87 PF09594.10 EXF79904.1 - 0.42 10.3 17.5 0.055 13.2 8.9 3.2 3 1 0 3 3 3 0 Glycosyltransferase family 87 UL41A PF17591.2 EXF79904.1 - 2.5 8.3 5.3 0.77 9.9 0.4 2.6 3 0 0 3 3 3 0 Herpesvirus UL41A HAUS-augmin3 PF14932.6 EXF79905.1 - 0.0011 18.6 10.9 0.0011 18.6 10.9 3.2 2 1 2 4 4 4 1 HAUS augmin-like complex subunit 3 STAT_alpha PF01017.20 EXF79905.1 - 0.0037 17.2 15.6 0.022 14.7 9.1 2.9 3 0 0 3 3 3 2 STAT protein, all-alpha domain DUF501 PF04417.12 EXF79905.1 - 0.023 14.5 3.5 0.059 13.2 1.5 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF501) AKNA PF12443.8 EXF79905.1 - 0.025 15.2 9.1 3.2 8.5 0.2 4.0 3 2 0 3 3 3 0 AT-hook-containing transcription factor UPF0176_N PF17773.1 EXF79905.1 - 0.15 12.5 0.8 1.1 9.7 0.0 2.7 3 0 0 3 3 3 0 UPF0176 acylphosphatase like domain Sec34 PF04136.15 EXF79905.1 - 1.2 9.0 17.1 1 9.2 1.4 3.2 2 1 0 2 2 2 0 Sec34-like family DLP_helical PF18709.1 EXF79905.1 - 1.6 7.8 14.6 0.16 11.1 6.6 2.8 3 1 0 3 3 3 0 Dynamin-like helical domain DivIC PF04977.15 EXF79905.1 - 2.5 7.9 12.4 4.5 7.1 2.6 3.7 2 1 1 3 3 3 0 Septum formation initiator EDR1 PF14381.6 EXF79905.1 - 5.4 6.7 8.0 28 4.3 2.6 2.9 2 1 1 3 3 3 0 Ethylene-responsive protein kinase Le-CTR1 Allexi_40kDa PF05549.11 EXF79905.1 - 8.2 5.8 17.4 2.3 7.7 6.9 2.9 1 1 2 3 3 3 0 Allexivirus 40kDa protein ArAE_2_N PF10337.9 EXF79905.1 - 9 5.2 8.8 1 8.3 3.8 1.8 2 1 1 3 3 3 0 Putative ER transporter, 6TM, N-terminal Sugar_tr PF00083.24 EXF79906.1 - 1.8e-89 300.7 21.2 2.1e-89 300.5 21.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF79906.1 - 8.6e-18 64.4 41.1 6.5e-12 45.0 12.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Peptidase_M24 PF00557.24 EXF79908.1 - 1.1e-51 175.5 0.0 1.5e-51 175.1 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 EXF79908.1 - 7.6e-26 90.3 0.0 1.6e-25 89.2 0.0 1.5 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain Peptidase_C12 PF01088.21 EXF79909.1 - 2.2e-52 177.9 0.0 2.5e-52 177.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 NicO PF03824.16 EXF79910.1 - 3e-68 230.2 4.4 4.4e-68 229.7 4.4 1.3 1 0 0 1 1 1 1 High-affinity nickel-transport protein Peptidase_C2 PF00648.21 EXF79912.1 - 2.5e-59 200.7 0.3 5.9e-58 196.2 0.3 2.3 1 1 0 1 1 1 1 Calpain family cysteine protease FAD_binding_2 PF00890.24 EXF79913.1 - 3.8e-80 270.0 0.2 4.6e-80 269.7 0.2 1.1 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EXF79913.1 - 1.5e-06 27.7 1.0 0.00081 18.7 0.4 3.0 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EXF79913.1 - 1.7e-06 27.6 0.8 3.4e-06 26.7 0.8 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO PF01266.24 EXF79913.1 - 2.4e-06 27.4 2.2 0.00036 20.2 1.5 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase Thi4 PF01946.17 EXF79913.1 - 2.6e-05 23.6 1.7 0.00044 19.6 0.7 2.2 2 0 0 2 2 2 1 Thi4 family NAD_binding_8 PF13450.6 EXF79913.1 - 0.0001 22.4 3.2 0.0003 20.9 3.2 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 EXF79913.1 - 0.00013 20.8 2.0 0.00014 20.7 0.9 1.5 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox_3 PF13738.6 EXF79913.1 - 0.0011 18.3 1.7 0.0037 16.6 0.7 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EXF79913.1 - 0.037 13.3 0.9 0.059 12.6 0.9 1.2 1 0 0 1 1 1 0 FAD binding domain UPF0227 PF05728.12 EXF79913.1 - 0.086 12.8 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) GIDA PF01134.22 EXF79913.1 - 0.95 8.5 3.3 9.2 5.2 2.1 2.1 2 0 0 2 2 2 0 Glucose inhibited division protein A MFS_1 PF07690.16 EXF79914.1 - 2.6e-18 66.1 19.5 2.6e-18 66.1 19.5 2.0 2 1 0 2 2 2 1 Major Facilitator Superfamily Glyco_transf_52 PF07922.11 EXF79914.1 - 0.031 13.6 0.0 0.045 13.1 0.0 1.1 1 0 0 1 1 1 0 Glycosyltransferase family 52 DUF4201 PF13870.6 EXF79916.1 - 5.2e-05 23.1 1.7 5.2e-05 23.1 1.7 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4201) Fungal_trans PF04082.18 EXF79917.1 - 0.0047 16.0 0.6 0.0084 15.2 0.6 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain WAK_assoc PF14380.6 EXF79917.1 - 0.4 11.4 2.1 0.41 11.4 0.3 1.9 2 0 0 2 2 2 0 Wall-associated receptor kinase C-terminal Git3 PF11710.8 EXF79918.1 - 4e-06 26.7 9.0 0.059 13.1 0.1 2.9 2 1 0 2 2 2 2 G protein-coupled glucose receptor regulating Gpa2 7tm_1 PF00001.21 EXF79918.1 - 0.009 15.4 0.1 0.099 12.0 0.1 2.3 3 0 0 3 3 3 1 7 transmembrane receptor (rhodopsin family) OapA_N PF08525.11 EXF79918.1 - 0.11 12.5 0.0 0.23 11.4 0.0 1.6 1 0 0 1 1 1 0 Opacity-associated protein A N-terminal motif DUF4678 PF15727.5 EXF79918.1 - 0.2 10.9 0.0 0.29 10.4 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4678) DUF2207 PF09972.9 EXF79918.1 - 8 5.1 10.4 3.1 6.5 0.0 2.4 3 0 0 3 3 3 0 Predicted membrane protein (DUF2207) DNA_ligase_A_C PF04679.15 EXF79919.1 - 0.019 15.5 0.0 0.042 14.4 0.0 1.5 1 0 0 1 1 1 0 ATP dependent DNA ligase C terminal region DIOX_N PF14226.6 EXF79920.1 - 9.7e-23 81.2 0.0 1.6e-22 80.4 0.0 1.4 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EXF79920.1 - 4.1e-22 78.6 0.0 1.4e-21 76.9 0.0 1.9 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily Peptidase_M35 PF02102.15 EXF79921.1 - 9.4e-69 232.0 3.7 1.2e-68 231.7 3.7 1.0 1 0 0 1 1 1 1 Deuterolysin metalloprotease (M35) family Aspzincin_M35 PF14521.6 EXF79921.1 - 1.5e-38 132.6 1.5 2e-38 132.2 0.9 1.5 1 1 0 1 1 1 1 Lysine-specific metallo-endopeptidase CARDB PF07705.11 EXF79921.1 - 0.11 12.8 0.1 0.43 10.9 0.0 2.0 2 0 0 2 2 2 0 CARDB GFO_IDH_MocA PF01408.22 EXF79922.1 - 1.1e-16 61.7 0.0 1.6e-16 61.2 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Sugar_tr PF00083.24 EXF79923.1 - 2.6e-87 293.6 17.5 3.1e-87 293.3 17.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF79923.1 - 2.8e-32 112.0 48.8 2.1e-24 86.1 24.6 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 EXF79923.1 - 0.003 15.9 0.5 3.2 6.0 0.0 3.0 3 0 0 3 3 3 2 Organic Anion Transporter Polypeptide (OATP) family TRI12 PF06609.13 EXF79923.1 - 0.0071 14.8 0.3 0.0071 14.8 0.3 2.8 3 0 0 3 3 3 2 Fungal trichothecene efflux pump (TRI12) GFO_IDH_MocA PF01408.22 EXF79924.1 - 7.3e-17 62.3 0.0 2.2e-16 60.7 0.0 1.8 2 0 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold Methyltransf_25 PF13649.6 EXF79924.1 - 0.054 14.2 0.0 0.12 13.0 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.12 EXF79924.1 - 0.13 13.0 0.2 0.42 11.4 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain PAN_1 PF00024.26 EXF79925.1 - 9.9e-12 44.7 20.6 1e-05 25.4 1.2 4.7 3 1 1 4 4 4 4 PAN domain PAN_4 PF14295.6 EXF79925.1 - 1.8e-05 24.5 28.8 0.019 14.8 1.8 4.9 4 1 0 4 4 4 3 PAN domain Sporozoite_P67 PF05642.11 EXF79925.1 - 1.4 6.9 14.1 3 5.8 14.1 1.5 1 0 0 1 1 1 0 Sporozoite P67 surface antigen PAN_2 PF08276.11 EXF79925.1 - 4.1 7.6 12.2 0.89 9.7 1.3 3.7 3 0 0 3 3 3 0 PAN-like domain Asparaginase_2 PF01112.18 EXF79926.1 - 0.26 10.3 5.8 0.28 10.1 5.8 1.1 1 0 0 1 1 1 0 Asparaginase Glyco_hydro_43 PF04616.14 EXF79927.1 - 1.1e-11 44.7 3.1 1.8e-11 43.9 3.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 tRNA-synt_1g PF09334.11 EXF79928.1 - 1.5e-142 475.0 1.1 1.3e-140 468.6 1.1 2.3 1 1 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 EXF79928.1 - 1.3e-06 27.0 8.3 0.00047 18.5 0.0 4.1 5 0 0 5 5 5 2 tRNA synthetases class I (I, L, M and V) 3HCDH_N PF02737.18 EXF79928.1 - 0.33 10.8 7.1 0.71 9.7 7.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ANAPC4_WD40 PF12894.7 EXF79929.1 - 9.3e-07 29.1 0.0 0.86 9.9 0.0 4.8 3 1 3 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EXF79929.1 - 3e-05 24.7 4.4 34 5.5 0.3 6.6 7 1 0 7 7 7 0 WD domain, G-beta repeat PD40 PF07676.12 EXF79929.1 - 0.00013 21.8 0.1 3.7 7.6 0.0 4.9 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat Proteasome_A_N PF10584.9 EXF79929.1 - 0.0014 18.3 0.1 1.5 8.5 0.0 3.6 4 0 0 4 4 4 1 Proteasome subunit A N-terminal signature Ge1_WD40 PF16529.5 EXF79929.1 - 0.018 14.0 0.4 1.4 7.8 0.0 3.2 3 1 1 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein TruB_C PF09142.11 EXF79929.1 - 0.21 11.4 7.4 0.78 9.6 0.0 4.4 4 2 1 5 5 5 0 tRNA Pseudouridine synthase II, C terminal ADH_N PF08240.12 EXF79930.1 - 9.9e-26 89.8 2.9 1.6e-25 89.1 2.9 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EXF79930.1 - 1.1e-14 54.5 0.1 5.9e-14 52.2 0.0 2.1 2 1 1 3 3 3 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 EXF79930.1 - 7.3e-05 22.2 0.2 0.00013 21.4 0.2 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ApbA PF02558.16 EXF79930.1 - 0.015 15.0 0.0 0.023 14.4 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA ADH_zinc_N_2 PF13602.6 EXF79930.1 - 0.15 13.1 0.0 0.25 12.4 0.0 1.3 1 0 0 1 1 1 0 Zinc-binding dehydrogenase WD40 PF00400.32 EXF79932.1 - 4.9e-31 106.3 14.3 1.1e-06 29.3 0.0 7.5 8 0 0 8 8 8 6 WD domain, G-beta repeat F-box-like PF12937.7 EXF79932.1 - 5.8e-09 35.7 0.0 1.4e-08 34.5 0.0 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EXF79932.1 - 1.7e-08 34.2 0.0 3.6e-08 33.1 0.0 1.6 1 0 0 1 1 1 1 F-box domain ANAPC4_WD40 PF12894.7 EXF79932.1 - 2.6e-07 30.9 0.6 0.02 15.2 0.0 4.7 2 1 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EXF79932.1 - 4.4e-05 22.3 0.6 1.3 7.5 0.0 3.6 1 1 2 4 4 4 2 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 EXF79932.1 - 0.0035 15.9 0.0 0.0063 15.1 0.0 1.3 1 0 0 1 1 1 1 Cytochrome D1 heme domain Ge1_WD40 PF16529.5 EXF79932.1 - 0.036 13.0 0.4 0.15 10.9 0.0 2.0 2 1 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ_2 PF13360.6 EXF79932.1 - 0.049 13.2 0.1 0.23 11.0 0.0 1.9 1 1 0 1 1 1 0 PQQ-like domain PQQ PF01011.21 EXF79932.1 - 0.15 12.1 0.1 6.4 6.9 0.0 3.4 4 0 0 4 4 4 0 PQQ enzyme repeat Pectate_lyase_3 PF12708.7 EXF79933.1 - 1.3e-91 306.3 22.2 1.3e-82 276.9 11.4 3.1 3 1 0 3 3 3 2 Pectate lyase superfamily protein End_N_terminal PF12218.8 EXF79933.1 - 7.6e-06 25.5 0.9 0.11 12.2 0.0 2.8 2 0 0 2 2 2 2 N terminal extension of bacteriophage endosialidase Scs3p PF10261.9 EXF79934.1 - 7.3e-75 251.7 7.4 9.8e-75 251.2 7.4 1.2 1 0 0 1 1 1 1 Inositol phospholipid synthesis and fat-storage-inducing TM ATP_transf PF09830.9 EXF79934.1 - 5.8e-20 71.2 0.0 1.5e-19 69.9 0.0 1.8 1 0 0 1 1 1 1 ATP adenylyltransferase Myb_DNA-bind_4 PF13837.6 EXF79935.1 - 0.0066 16.8 0.5 0.014 15.7 0.0 1.8 2 0 0 2 2 2 1 Myb/SANT-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EXF79935.1 - 0.073 13.3 0.0 0.22 11.8 0.0 1.8 1 0 0 1 1 1 0 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 EXF79935.1 - 0.09 13.0 0.1 0.2 11.9 0.1 1.6 1 1 0 1 1 1 0 Myb-like DNA-binding domain DUF4699 PF15770.5 EXF79935.1 - 2.4 7.8 6.9 0.35 10.6 2.6 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4699) DUF1752 PF08550.10 EXF79936.1 - 0.00013 21.7 2.2 0.00026 20.8 2.2 1.5 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) LisH_2 PF16045.5 EXF79937.1 - 0.27 10.3 1.2 0.55 9.3 1.2 1.4 1 0 0 1 1 1 0 LisH CTP_transf_like PF01467.26 EXF79938.1 - 3.9e-22 79.0 0.0 5.1e-22 78.6 0.0 1.2 1 0 0 1 1 1 1 Cytidylyltransferase-like 7tm_2 PF00002.24 EXF79940.1 - 1.3e-09 37.8 8.6 1.3e-09 37.8 8.6 1.6 2 0 0 2 2 2 1 7 transmembrane receptor (Secretin family) Dicty_CAR PF05462.11 EXF79940.1 - 2.3e-07 30.3 8.8 2.3e-07 30.3 8.8 2.0 2 0 0 2 2 2 1 Slime mold cyclic AMP receptor 7tm_1 PF00001.21 EXF79940.1 - 2.1e-06 27.3 3.8 2.8e-06 26.9 3.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Git3 PF11710.8 EXF79940.1 - 2.7e-06 27.3 10.2 4.6e-06 26.5 10.2 1.3 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 Ocular_alb PF02101.15 EXF79940.1 - 1.6 7.6 7.0 2.8 6.8 7.0 1.4 1 0 0 1 1 1 0 Ocular albinism type 1 protein Fungal_trans_2 PF11951.8 EXF79941.1 - 0.00035 19.5 0.1 0.0012 17.8 0.0 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain PSII_Pbs31 PF18240.1 EXF79941.1 - 0.032 14.6 0.0 0.082 13.4 0.0 1.6 1 0 0 1 1 1 0 Photosystem II Psb31 protein Abhydrolase_6 PF12697.7 EXF79942.1 - 5.1e-13 50.1 0.9 6.4e-13 49.8 0.9 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EXF79942.1 - 1.9e-10 40.8 0.0 3e-10 40.2 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EXF79942.1 - 0.0039 16.5 0.0 0.01 15.2 0.0 1.6 1 1 0 1 1 1 1 Serine aminopeptidase, S33 TPR_12 PF13424.6 EXF79943.1 - 1.4e-29 102.2 56.8 1.1e-05 25.6 2.1 13.1 11 3 2 13 13 13 7 Tetratricopeptide repeat Pkinase PF00069.25 EXF79943.1 - 7.1e-24 84.6 0.0 2e-23 83.1 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Ank_2 PF12796.7 EXF79943.1 - 2.2e-21 76.3 0.1 0.00012 22.6 0.0 7.0 3 2 0 5 5 5 4 Ankyrin repeats (3 copies) Pkinase_Tyr PF07714.17 EXF79943.1 - 4.5e-19 68.8 0.0 1.1e-18 67.5 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase Ank_3 PF13606.6 EXF79943.1 - 2.2e-14 52.1 10.2 0.65 10.7 0.0 11.3 12 0 0 12 12 10 3 Ankyrin repeat TPR_10 PF13374.6 EXF79943.1 - 2.6e-12 46.2 35.0 0.024 14.5 1.7 14.2 14 0 0 14 14 14 3 Tetratricopeptide repeat Ank_4 PF13637.6 EXF79943.1 - 5e-08 33.3 5.0 0.45 11.2 0.0 6.8 5 3 3 8 8 8 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EXF79943.1 - 2.9e-06 27.4 1.0 5.8 7.4 0.0 7.0 7 0 0 7 7 6 1 Ankyrin repeats (many copies) Ank PF00023.30 EXF79943.1 - 0.00013 22.3 13.3 2.9 8.5 0.0 7.7 8 0 0 8 8 7 1 Ankyrin repeat TPR_2 PF07719.17 EXF79943.1 - 0.00043 20.2 37.5 1.9 8.8 0.6 11.8 13 0 0 13 13 13 3 Tetratricopeptide repeat TPR_MalT PF17874.1 EXF79943.1 - 0.00063 19.2 6.8 0.00063 19.2 6.8 5.0 3 1 0 5 5 5 1 MalT-like TPR region TPR_14 PF13428.6 EXF79943.1 - 0.0015 19.2 38.5 3.3 8.8 0.1 12.7 12 2 2 14 14 13 2 Tetratricopeptide repeat TPR_8 PF13181.6 EXF79943.1 - 0.0025 17.9 22.4 9.4 6.7 0.1 9.5 11 0 0 11 11 11 1 Tetratricopeptide repeat TPR_19 PF14559.6 EXF79943.1 - 0.0075 16.8 31.8 0.29 11.7 0.2 9.9 10 2 2 12 12 10 2 Tetratricopeptide repeat Kdo PF06293.14 EXF79943.1 - 0.027 13.8 0.1 0.067 12.5 0.1 1.6 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family SPO22 PF08631.10 EXF79943.1 - 0.39 10.2 7.5 0.082 12.4 1.2 3.1 2 1 1 3 3 3 0 Meiosis protein SPO22/ZIP4 like ANAPC3 PF12895.7 EXF79943.1 - 2.5 8.4 13.6 5.1 7.4 0.1 7.0 8 2 1 9 9 8 0 Anaphase-promoting complex, cyclosome, subunit 3 HeLo PF14479.6 EXF79944.1 - 2.7e-14 53.5 0.3 7e-14 52.1 0.3 1.7 1 1 0 1 1 1 1 Prion-inhibition and propagation Pkinase PF00069.25 EXF79944.1 - 0.00095 18.6 0.0 0.0014 18.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF79944.1 - 0.074 12.3 0.0 0.19 11.0 0.0 1.6 1 1 0 1 1 1 0 Protein tyrosine kinase HET PF06985.11 EXF79945.1 - 9.9e-26 90.8 0.1 2.4e-25 89.6 0.1 1.7 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Pkinase PF00069.25 EXF79945.1 - 2.1e-20 73.2 0.0 3.4e-20 72.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF79945.1 - 1.2e-14 54.2 0.0 2.1e-14 53.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pox_ser-thr_kin PF05445.11 EXF79945.1 - 0.053 12.5 0.0 0.082 11.9 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Pkinase PF00069.25 EXF79946.1 - 4.4e-13 49.2 0.0 3.5e-12 46.2 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF79946.1 - 0.00015 21.2 0.0 0.00066 19.0 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.25 EXF79948.1 - 7.2e-28 97.7 0.0 1.6e-24 86.7 0.0 3.2 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EXF79948.1 - 4.4e-14 52.4 0.0 1.8e-05 24.1 0.0 4.0 3 1 1 4 4 4 4 Protein tyrosine kinase RIO1 PF01163.22 EXF79948.1 - 0.17 11.5 0.0 0.29 10.7 0.0 1.3 1 0 0 1 1 1 0 RIO1 family Peptidase_S8 PF00082.22 EXF79949.1 - 3.1e-42 144.9 1.5 5.8e-42 144.0 1.5 1.4 1 0 0 1 1 1 1 Subtilase family fn3_5 PF06280.12 EXF79949.1 - 3.6e-10 40.6 0.0 7.4e-10 39.5 0.0 1.6 1 0 0 1 1 1 1 Fn3-like domain DUF4232 PF14016.6 EXF79949.1 - 0.0038 17.4 0.5 0.0038 17.4 0.5 2.2 3 0 0 3 3 3 1 Protein of unknown function (DUF4232) Trypsin PF00089.26 EXF79950.1 - 1e-12 48.4 0.1 1.5e-12 47.8 0.1 1.1 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 EXF79950.1 - 3.8e-07 31.1 0.2 1.4e-06 29.3 0.1 1.8 2 0 0 2 2 2 1 Trypsin-like peptidase domain MFS_1 PF07690.16 EXF79951.1 - 4.6e-33 114.6 31.4 8e-33 113.8 31.5 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily Phage_holin_3_6 PF07332.11 EXF79951.1 - 2.2 8.3 5.7 0.4 10.7 0.1 2.6 2 1 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III FMO-like PF00743.19 EXF79952.1 - 2.5e-15 55.9 0.0 8.1e-15 54.2 0.0 1.7 2 0 0 2 2 2 1 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.6 EXF79952.1 - 3.4e-10 40.0 0.0 4.1e-09 36.6 0.0 2.5 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 EXF79952.1 - 6.3e-10 39.3 0.6 2.9e-08 33.8 0.1 3.2 3 1 0 3 3 3 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 EXF79952.1 - 3.1e-09 36.5 0.0 2.6e-08 33.5 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EXF79952.1 - 6.4e-08 32.1 0.0 4e-06 26.2 0.0 2.7 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.6 EXF79952.1 - 8.4e-07 28.5 0.2 0.00032 20.1 0.3 3.0 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 EXF79952.1 - 0.00017 21.0 0.0 0.00064 19.1 0.0 1.8 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase Pyr_redox PF00070.27 EXF79952.1 - 0.0034 17.9 0.0 4.6 7.9 0.0 2.7 3 0 0 3 3 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EXF79952.1 - 0.0034 17.0 0.4 0.046 13.3 0.1 2.5 2 1 1 3 3 3 1 FAD dependent oxidoreductase Thi4 PF01946.17 EXF79952.1 - 0.0058 15.9 0.0 0.013 14.8 0.0 1.5 1 0 0 1 1 1 1 Thi4 family FAD_binding_3 PF01494.19 EXF79952.1 - 0.022 14.0 0.1 0.042 13.1 0.1 1.4 1 0 0 1 1 1 0 FAD binding domain HI0933_like PF03486.14 EXF79952.1 - 0.031 13.0 0.1 0.046 12.4 0.1 1.2 1 0 0 1 1 1 0 HI0933-like protein F-box PF00646.33 EXF79953.1 - 0.0068 16.3 1.1 0.024 14.5 1.1 1.9 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EXF79953.1 - 0.0069 16.3 0.2 0.022 14.6 0.2 1.9 1 0 0 1 1 1 1 F-box-like 2-Hacid_dh_C PF02826.19 EXF79954.1 - 1.8e-55 187.1 0.1 3.7e-55 186.0 0.0 1.5 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EXF79954.1 - 3.5e-32 110.9 0.0 4.5e-32 110.5 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 EXF79954.1 - 3.4e-08 33.8 0.0 1.8e-07 31.5 0.0 1.9 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase CoA_binding_2 PF13380.6 EXF79954.1 - 0.00063 20.2 0.0 0.0021 18.6 0.0 1.8 2 0 0 2 2 2 1 CoA binding domain AlaDh_PNT_C PF01262.21 EXF79954.1 - 0.00067 19.0 0.5 0.023 14.0 0.5 2.4 1 1 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain IlvN PF07991.12 EXF79954.1 - 0.00074 19.1 0.0 0.0051 16.4 0.0 2.0 2 0 0 2 2 2 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain AdoHcyase_NAD PF00670.21 EXF79954.1 - 0.018 15.1 0.0 0.042 13.9 0.0 1.5 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain GFO_IDH_MocA PF01408.22 EXF79954.1 - 0.028 15.3 2.1 1.7 9.4 0.1 3.1 2 1 0 2 2 2 0 Oxidoreductase family, NAD-binding Rossmann fold HisG_C PF08029.11 EXF79954.1 - 0.032 14.4 0.1 0.075 13.2 0.0 1.6 2 0 0 2 2 2 0 HisG, C-terminal domain 3HCDH_N PF02737.18 EXF79954.1 - 0.11 12.4 0.4 0.62 9.9 0.0 2.2 2 1 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Semialdhyde_dh PF01118.24 EXF79954.1 - 0.57 10.6 2.4 18 5.8 0.1 2.4 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain MFS_1 PF07690.16 EXF79955.1 - 2.2e-40 138.7 32.7 2.2e-40 138.7 32.7 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EXF79955.1 - 2.5e-07 29.5 4.8 4e-07 28.9 4.8 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EXF79955.1 - 1.3e-05 24.3 26.2 6.8e-05 21.9 26.2 2.2 1 1 0 1 1 1 1 Sugar (and other) transporter DUF2178 PF09946.9 EXF79955.1 - 2.8 8.1 8.6 2.4 8.4 3.1 2.9 2 1 0 2 2 2 0 Predicted membrane protein (DUF2178) RSN1_7TM PF02714.15 EXF79956.1 - 6.3e-66 222.5 30.0 1e-65 221.8 30.0 1.3 1 0 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate PHM7_cyt PF14703.6 EXF79956.1 - 3.5e-39 134.8 0.2 1.5e-38 132.8 0.0 2.0 2 0 0 2 2 2 1 Cytosolic domain of 10TM putative phosphate transporter RSN1_TM PF13967.6 EXF79956.1 - 9.1e-36 123.0 0.5 5.4e-35 120.5 0.5 2.5 1 0 0 1 1 1 1 Late exocytosis, associated with Golgi transport KASH_CCD PF14662.6 EXF79958.1 - 0.00039 20.3 20.7 0.00039 20.3 20.7 2.3 1 1 1 2 2 2 1 Coiled-coil region of CCDC155 or KASH ZapB PF06005.12 EXF79958.1 - 0.0018 18.7 10.9 0.0018 18.7 10.9 4.4 1 1 3 4 4 3 1 Cell division protein ZapB CENP-F_leu_zip PF10473.9 EXF79958.1 - 0.0023 17.9 6.0 0.0023 17.9 6.0 3.3 1 1 2 3 3 3 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ADIP PF11559.8 EXF79958.1 - 0.0039 17.3 12.4 0.0039 17.3 12.4 3.8 1 1 2 4 4 4 1 Afadin- and alpha -actinin-Binding Cut12 PF11500.8 EXF79958.1 - 0.0046 16.9 3.6 0.0046 16.9 3.6 2.9 2 1 1 3 3 1 1 Spindle pole body formation-associated protein DUF1515 PF07439.11 EXF79958.1 - 0.027 14.5 1.0 0.027 14.5 1.0 3.2 1 1 2 3 3 3 0 Protein of unknown function (DUF1515) YabA PF06156.13 EXF79958.1 - 0.27 11.9 25.2 3 8.5 11.2 3.3 1 1 1 2 2 2 0 Initiation control protein YabA GPCR_chapero_1 PF11904.8 EXF79958.1 - 1.4 8.3 10.8 2.4 7.5 10.8 1.3 1 0 0 1 1 1 0 GPCR-chaperone EMP24_GP25L PF01105.24 EXF79958.1 - 1.5 8.8 11.8 0.11 12.4 3.4 2.9 2 1 1 3 3 3 0 emp24/gp25L/p24 family/GOLD Trans_reg_C PF00486.28 EXF79958.1 - 2.5 8.2 10.1 1.6 8.9 1.0 3.0 3 0 0 3 3 3 0 Transcriptional regulatory protein, C terminal V_ATPase_I PF01496.19 EXF79958.1 - 3.7 5.3 20.9 3.6 5.4 19.4 1.5 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family DUF3450 PF11932.8 EXF79958.1 - 4.7 6.4 30.5 0.29 10.4 14.4 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) FlaC_arch PF05377.11 EXF79958.1 - 6.9 7.2 8.0 1.5 9.2 0.6 3.5 3 1 1 4 4 4 0 Flagella accessory protein C (FlaC) Fib_alpha PF08702.10 EXF79958.1 - 9 6.5 23.5 0.59 10.3 10.5 2.5 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family K_trans PF02705.16 EXF79959.1 - 1.1e-183 611.6 18.2 1.3e-183 611.4 18.2 1.0 1 0 0 1 1 1 1 K+ potassium transporter Aminotran_4 PF01063.19 EXF79960.1 - 2.4e-21 76.6 0.0 3e-21 76.3 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV Zn_clus PF00172.18 EXF79961.1 - 2e-09 37.4 9.2 3.8e-09 36.5 9.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EXF79961.1 - 0.011 14.7 0.3 0.034 13.2 0.3 1.8 1 0 0 1 1 1 0 Fungal specific transcription factor domain Ring_hydroxyl_A PF00848.19 EXF79962.1 - 9.2e-15 55.2 4.3 1.1e-10 41.9 0.1 2.3 1 1 1 2 2 2 2 Ring hydroxylating alpha subunit (catalytic domain) Rieske PF00355.26 EXF79962.1 - 3.7e-14 52.4 0.0 6.5e-14 51.6 0.0 1.4 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain FMO-like PF00743.19 EXF79963.1 - 3.8e-19 68.5 0.0 9.1e-19 67.3 0.0 1.6 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.6 EXF79963.1 - 8.1e-14 51.6 0.0 4.7e-13 49.2 0.0 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 EXF79963.1 - 2.4e-13 50.0 0.0 1.8e-12 47.2 0.0 2.3 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EXF79963.1 - 1.3e-09 37.7 0.0 2.7e-05 23.5 0.0 2.3 2 0 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.14 EXF79963.1 - 1.1e-06 28.1 0.0 1.8e-05 24.1 0.0 2.2 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EXF79963.1 - 2.3e-06 27.7 0.0 2e-05 24.6 0.0 2.5 2 0 0 2 2 2 1 FAD-NAD(P)-binding DAO PF01266.24 EXF79963.1 - 3.1e-06 27.0 0.0 8.5e-05 22.3 0.0 2.5 2 1 1 3 3 3 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 EXF79963.1 - 0.0028 18.2 0.0 0.14 12.8 0.0 2.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EXF79963.1 - 0.0035 16.6 0.0 0.01 15.1 0.0 1.7 1 0 0 1 1 1 1 Thi4 family Lycopene_cycl PF05834.12 EXF79963.1 - 0.039 13.0 0.0 2 7.4 0.0 2.4 3 0 0 3 3 3 0 Lycopene cyclase protein Shikimate_DH PF01488.20 EXF79963.1 - 0.097 12.7 0.0 4.9 7.2 0.0 2.3 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase DUF2524 PF10732.9 EXF79963.1 - 0.16 12.3 1.1 0.39 11.0 1.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2524) Glyco_transf_20 PF00982.21 EXF79964.1 - 3.8e-165 550.2 0.0 5.2e-165 549.7 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 EXF79964.1 - 6.5e-45 153.1 0.0 2.2e-44 151.3 0.0 1.8 2 0 0 2 2 2 1 Trehalose-phosphatase Glyco_transf_5 PF08323.11 EXF79964.1 - 0.075 12.7 0.3 0.15 11.7 0.3 1.4 1 0 0 1 1 1 0 Starch synthase catalytic domain WD40 PF00400.32 EXF79965.1 - 4.6e-55 182.3 35.8 2e-10 41.1 0.4 9.2 8 1 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EXF79965.1 - 2.4e-19 69.4 8.0 0.0017 18.6 0.1 6.1 3 3 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EXF79965.1 - 7.3e-09 35.0 0.0 0.29 10.0 0.0 4.7 3 2 2 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 EXF79965.1 - 9e-07 29.0 0.4 0.00081 19.3 0.0 3.3 3 1 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 EXF79965.1 - 0.0053 15.5 3.5 0.6 8.7 0.1 3.9 4 1 0 4 4 4 2 Nucleoporin Nup120/160 PD40 PF07676.12 EXF79965.1 - 0.0092 15.9 0.0 5.4 7.1 0.0 3.0 3 0 0 3 3 3 2 WD40-like Beta Propeller Repeat NLE PF08154.12 EXF79965.1 - 0.018 15.6 0.0 0.039 14.5 0.0 1.5 1 0 0 1 1 1 0 NLE (NUC135) domain DinB PF05163.12 EXF79965.1 - 0.05 13.5 0.1 0.089 12.7 0.1 1.3 1 0 0 1 1 1 0 DinB family WD40_like PF17005.5 EXF79965.1 - 0.3 10.4 0.0 27 4.0 0.0 3.1 4 0 0 4 4 4 0 WD40-like domain FAR1 PF03101.15 EXF79966.1 - 6.7e-05 23.5 2.6 6.7e-05 23.5 2.6 2.9 2 1 0 2 2 2 1 FAR1 DNA-binding domain PAT1 PF09770.9 EXF79966.1 - 1.3 7.1 50.0 2.2 6.5 50.0 1.4 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 MutS_V PF00488.21 EXF79967.1 - 3.9e-59 199.9 1.1 6.7e-59 199.1 1.1 1.4 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 EXF79967.1 - 2.6e-26 93.1 0.6 2.6e-26 93.1 0.6 2.1 2 0 0 2 2 2 1 MutS domain III MutS_IV PF05190.18 EXF79967.1 - 8e-05 22.9 0.6 0.00021 21.6 0.0 2.0 2 0 0 2 2 2 1 MutS family domain IV MutS_II PF05188.17 EXF79967.1 - 0.00016 22.0 0.0 0.00051 20.3 0.0 1.9 1 0 0 1 1 1 1 MutS domain II AAA_27 PF13514.6 EXF79967.1 - 0.035 13.7 0.3 0.69 9.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain GFO_IDH_MocA PF01408.22 EXF79969.1 - 5.5e-25 88.5 0.5 2.3e-24 86.5 0.2 2.0 2 0 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 EXF79969.1 - 1e-05 25.5 0.0 2.1e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain NAD_binding_2 PF03446.15 EXF79969.1 - 0.017 15.3 0.1 0.042 14.0 0.1 1.8 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase CoA_binding PF02629.19 EXF79969.1 - 0.1 13.3 0.0 0.4 11.4 0.0 2.0 2 0 0 2 2 2 0 CoA binding domain Fungal_trans_2 PF11951.8 EXF79970.1 - 1e-10 41.0 0.8 1e-10 41.0 0.8 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF79970.1 - 0.021 14.9 4.5 0.048 13.8 4.5 1.6 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Sugar_tr PF00083.24 EXF79971.1 - 5.1e-123 411.3 18.2 8.7e-123 410.5 18.2 1.3 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF79971.1 - 1.9e-29 102.7 52.3 1.7e-24 86.4 29.2 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_5 PF05631.14 EXF79971.1 - 0.0013 17.7 1.1 0.0038 16.2 0.3 2.1 2 0 0 2 2 2 1 Sugar-tranasporters, 12 TM ALMT PF11744.8 EXF79971.1 - 0.6 8.9 1.6 1.1 8.0 1.6 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter Fungal_trans PF04082.18 EXF79972.1 - 2.6e-19 69.3 0.1 3.8e-19 68.8 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Glucos_trans_II PF14264.6 EXF79972.1 - 0.35 10.2 2.0 9.7 5.4 0.2 2.1 2 0 0 2 2 2 0 Glucosyl transferase GtrII Sugar_tr PF00083.24 EXF79973.1 - 5.9e-111 371.5 21.2 7.2e-111 371.2 21.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF79973.1 - 1.1e-22 80.5 24.2 1.8e-15 56.8 1.1 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily DUF4131 PF13567.6 EXF79973.1 - 0.93 9.1 0.0 0.93 9.1 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4131) OATP PF03137.20 EXF79973.1 - 2.7 6.2 9.5 0.19 10.0 3.5 2.0 2 1 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family Dynamin_M PF01031.20 EXF79974.1 - 5.6e-25 88.1 1.4 1.5e-14 53.9 0.0 3.7 4 0 0 4 4 4 2 Dynamin central region Dynamin_N PF00350.23 EXF79974.1 - 1.2e-19 70.9 0.1 4.6e-19 69.1 0.0 2.1 2 1 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.23 EXF79974.1 - 9.6e-05 22.4 0.1 0.0012 18.9 0.1 2.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_28 PF13521.6 EXF79974.1 - 0.0004 20.7 2.0 0.0012 19.1 0.0 2.7 3 0 0 3 3 3 1 AAA domain FeoB_N PF02421.18 EXF79974.1 - 0.008 15.7 0.0 1.1 8.8 0.0 2.4 2 0 0 2 2 2 2 Ferrous iron transport protein B Roc PF08477.13 EXF79974.1 - 0.033 14.4 0.2 2 8.7 0.1 3.0 2 1 1 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase Sugar_tr PF00083.24 EXF79975.1 - 1.6e-90 304.2 25.3 1.8e-90 304.0 25.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF79975.1 - 3.3e-19 69.0 23.5 3.3e-19 69.0 23.5 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily Fungal_trans PF04082.18 EXF79976.1 - 3.2e-09 36.2 1.3 7.3e-09 35.0 1.3 1.6 1 1 0 1 1 1 1 Fungal specific transcription factor domain Glyco_hydro_3_C PF01915.22 EXF79977.1 - 1e-54 185.6 0.0 1.6e-54 185.0 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 EXF79977.1 - 1.8e-53 182.0 0.0 3e-53 181.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 EXF79977.1 - 3.2e-20 72.0 0.0 1e-19 70.4 0.0 1.8 2 0 0 2 2 2 1 Fibronectin type III-like domain PA14 PF07691.12 EXF79977.1 - 1.7e-15 57.1 0.1 3.5e-15 56.1 0.1 1.5 1 0 0 1 1 1 1 PA14 domain GLEYA PF10528.9 EXF79977.1 - 0.025 15.0 0.1 0.074 13.5 0.1 1.9 1 0 0 1 1 1 0 GLEYA domain DUF2808 PF10989.8 EXF79977.1 - 0.091 12.7 0.0 8.9 6.3 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2808) Cren7 PF11520.8 EXF79977.1 - 0.098 12.6 0.0 0.28 11.1 0.0 1.7 1 0 0 1 1 1 0 Chromatin protein Cren7 adh_short_C2 PF13561.6 EXF79978.1 - 4.2e-40 137.7 2.8 5e-40 137.5 2.8 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF79978.1 - 1.3e-37 129.2 2.7 1.6e-37 128.9 2.7 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EXF79978.1 - 3.5e-10 40.1 0.2 5.2e-10 39.5 0.2 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EXF79978.1 - 0.0018 17.8 0.5 0.017 14.6 0.5 2.1 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family LuxS PF02664.15 EXF79978.1 - 0.17 11.6 0.0 0.24 11.1 0.0 1.3 1 0 0 1 1 1 0 S-Ribosylhomocysteinase (LuxS) MOSC PF03473.17 EXF79979.1 - 2e-25 89.3 0.0 3.6e-25 88.5 0.0 1.5 1 0 0 1 1 1 1 MOSC domain MOSC_N PF03476.16 EXF79979.1 - 1.3e-10 41.2 0.0 4.1e-06 26.7 0.0 2.5 2 1 0 2 2 2 2 MOSC N-terminal beta barrel domain Fungal_trans_2 PF11951.8 EXF79980.1 - 4.6e-31 108.0 1.6 6.1e-31 107.6 1.6 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF79980.1 - 6.1e-10 39.1 11.7 6.1e-10 39.1 11.7 1.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Aldedh PF00171.22 EXF79981.1 - 3.5e-184 612.6 0.2 4e-184 612.4 0.2 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Rotamase_2 PF13145.6 EXF79981.1 - 0.05 14.4 0.3 0.11 13.3 0.3 1.5 1 0 0 1 1 1 0 PPIC-type PPIASE domain Ribonuc_L-PSP PF01042.21 EXF79982.1 - 5.5e-21 74.8 0.0 6.3e-21 74.6 0.0 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP Hit1_C PF18268.1 EXF79982.1 - 0.06 13.5 0.0 0.11 12.7 0.0 1.4 1 1 0 1 1 1 0 Hit1 C-terminal MFS_1 PF07690.16 EXF79983.1 - 8.8e-30 103.8 23.3 8.8e-30 103.8 23.3 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily ADH_N PF08240.12 EXF79984.1 - 4.7e-30 103.7 3.4 7.4e-30 103.1 3.4 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EXF79984.1 - 9.5e-26 90.3 0.8 2.1e-25 89.2 0.0 1.9 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EXF79984.1 - 5.4e-09 35.8 0.3 4.3e-08 32.9 0.3 2.1 1 1 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 EXF79984.1 - 4.3e-08 34.3 0.1 9.1e-08 33.2 0.1 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 EXF79984.1 - 1.3e-05 24.6 2.2 1.7e-05 24.2 1.1 1.6 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain ADH_N_assoc PF13823.6 EXF79984.1 - 0.00097 19.0 0.0 0.0016 18.3 0.0 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-associated NAS PF03059.16 EXF79984.1 - 0.059 12.7 0.0 0.1 12.0 0.0 1.3 1 0 0 1 1 1 0 Nicotianamine synthase protein SET PF00856.28 EXF79985.1 - 1.2e-16 61.6 0.1 1.1e-15 58.4 0.0 2.6 2 2 0 2 2 2 1 SET domain TPR_2 PF07719.17 EXF79985.1 - 1.7e-08 33.9 5.0 4e-07 29.7 1.1 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 EXF79985.1 - 1.3e-06 27.9 5.4 0.00026 20.7 0.5 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 EXF79985.1 - 4.1e-05 23.5 4.9 0.00013 21.9 0.3 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 EXF79985.1 - 0.0024 18.1 3.2 0.0059 16.9 3.2 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_14 PF13428.6 EXF79985.1 - 0.009 16.8 0.1 0.009 16.8 0.1 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat SAF PF08666.12 EXF79985.1 - 0.035 14.7 0.0 7.8 7.2 0.0 2.8 2 0 0 2 2 2 0 SAF domain DMAP1 PF05499.12 EXF79985.1 - 0.12 12.2 0.2 0.12 12.2 0.2 2.1 2 0 0 2 2 2 0 DNA methyltransferase 1-associated protein 1 (DMAP1) Trimer_CC PF08954.11 EXF79985.1 - 0.8 9.3 5.5 0.14 11.7 0.8 2.2 2 0 0 2 2 2 0 Trimerisation motif Cyclase PF04199.13 EXF79987.1 - 1.9e-15 57.3 0.1 2.6e-15 56.9 0.1 1.2 1 0 0 1 1 1 1 Putative cyclase NAD_binding_8 PF13450.6 EXF79988.1 - 3.3e-05 24.0 0.0 0.00019 21.6 0.0 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EXF79988.1 - 0.00022 20.6 0.0 0.017 14.3 0.0 2.8 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EXF79988.1 - 0.0019 18.2 0.0 0.13 12.2 0.0 2.8 3 0 0 3 3 3 1 FAD-NAD(P)-binding 2-Hacid_dh_C PF02826.19 EXF79988.1 - 0.0079 15.6 0.0 0.016 14.5 0.0 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain F420_oxidored PF03807.17 EXF79988.1 - 0.025 15.1 0.1 9.3 6.9 0.0 3.0 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.20 EXF79988.1 - 0.037 14.1 0.0 0.13 12.3 0.0 1.9 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase GARS_A PF01071.19 EXF79988.1 - 0.1 12.4 0.0 0.3 10.8 0.0 1.7 2 0 0 2 2 2 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain GMC_oxred_N PF00732.19 EXF79989.1 - 3.5e-17 62.7 0.6 3e-16 59.7 0.6 2.3 1 1 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EXF79989.1 - 2.6e-16 60.5 0.4 4.3e-16 59.7 0.4 1.4 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.24 EXF79989.1 - 1.9e-06 27.3 0.0 0.0028 16.8 0.0 2.4 2 0 0 2 2 2 2 FAD binding domain Pyr_redox PF00070.27 EXF79989.1 - 5.9e-05 23.6 0.0 0.28 11.8 0.0 3.4 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EXF79989.1 - 8.7e-05 22.7 0.2 0.00034 20.8 0.0 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EXF79989.1 - 9.7e-05 21.7 0.4 0.00028 20.2 0.0 1.9 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EXF79989.1 - 0.00024 20.6 0.0 0.0077 15.6 0.0 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase DAO PF01266.24 EXF79989.1 - 0.00035 20.3 3.0 0.0034 17.0 3.0 2.3 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 EXF79989.1 - 0.0018 17.6 0.0 0.0045 16.3 0.0 1.6 2 0 0 2 2 2 1 FAD binding domain HI0933_like PF03486.14 EXF79989.1 - 0.0062 15.3 0.0 0.012 14.4 0.0 1.4 1 0 0 1 1 1 1 HI0933-like protein Lycopene_cycl PF05834.12 EXF79989.1 - 0.025 13.6 0.0 0.037 13.1 0.0 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein Pyr_redox_3 PF13738.6 EXF79989.1 - 0.077 12.2 0.0 0.17 11.1 0.0 1.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase ABC_tran PF00005.27 EXF79990.1 - 2.3e-47 160.9 0.0 3e-25 89.3 0.0 2.5 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EXF79990.1 - 6.7e-33 114.5 19.3 1.2e-26 94.0 9.4 2.3 2 0 0 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.19 EXF79990.1 - 9.6e-12 44.8 2.4 0.00036 20.1 0.1 4.2 3 1 0 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EXF79990.1 - 2.1e-09 37.6 5.6 0.16 11.7 0.0 4.4 3 1 1 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EXF79990.1 - 6.2e-08 32.3 0.5 0.013 15.2 0.2 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.6 EXF79990.1 - 9.8e-08 32.4 2.8 0.011 16.0 0.0 3.6 2 1 0 2 2 2 2 AAA domain T2SSE PF00437.20 EXF79990.1 - 4.3e-07 29.3 0.6 0.01 14.9 0.1 2.7 3 0 0 3 3 3 2 Type II/IV secretion system protein AAA_16 PF13191.6 EXF79990.1 - 1.4e-05 25.5 1.5 0.016 15.6 0.0 3.0 3 0 0 3 3 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 EXF79990.1 - 4.4e-05 23.5 0.0 0.15 12.0 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_23 PF13476.6 EXF79990.1 - 9.1e-05 23.0 1.4 0.19 12.2 0.1 2.4 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 EXF79990.1 - 0.0001 22.9 0.3 0.02 15.4 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EXF79990.1 - 0.00024 21.3 0.0 0.1 12.8 0.0 2.6 2 0 0 2 2 2 1 AAA domain SbcCD_C PF13558.6 EXF79990.1 - 0.00029 21.0 0.7 0.02 15.1 0.0 2.9 2 1 0 2 2 2 1 Putative exonuclease SbcCD, C subunit FtsK_SpoIIIE PF01580.18 EXF79990.1 - 0.00031 20.2 0.1 0.48 9.7 0.0 2.4 2 0 0 2 2 2 2 FtsK/SpoIIIE family AAA_25 PF13481.6 EXF79990.1 - 0.00071 19.2 1.5 1.3 8.6 0.0 3.7 4 0 0 4 4 4 1 AAA domain TsaE PF02367.17 EXF79990.1 - 0.001 19.0 0.3 0.39 10.7 0.0 2.5 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE MMR_HSR1 PF01926.23 EXF79990.1 - 0.0014 18.6 0.7 1.6 8.9 0.1 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase IstB_IS21 PF01695.17 EXF79990.1 - 0.005 16.6 1.7 1.5 8.5 0.0 3.0 3 0 0 3 3 2 1 IstB-like ATP binding protein AAA_30 PF13604.6 EXF79990.1 - 0.005 16.6 2.2 0.18 11.5 0.1 3.2 3 0 0 3 3 3 1 AAA domain NACHT PF05729.12 EXF79990.1 - 0.0093 15.9 4.5 0.67 9.9 0.2 3.8 3 0 0 3 3 3 1 NACHT domain AAA_7 PF12775.7 EXF79990.1 - 0.034 13.6 0.1 8.8 5.8 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_15 PF13175.6 EXF79990.1 - 0.035 13.8 0.6 5.9 6.5 0.1 2.4 2 0 0 2 2 2 0 AAA ATPase domain DUF87 PF01935.17 EXF79990.1 - 0.037 14.1 0.1 0.037 14.1 0.1 2.6 3 0 0 3 3 2 0 Helicase HerA, central domain NB-ARC PF00931.22 EXF79990.1 - 0.043 13.0 0.2 4 6.6 0.1 2.6 3 0 0 3 3 3 0 NB-ARC domain Pox_A32 PF04665.12 EXF79990.1 - 0.078 12.4 0.7 7.7 5.9 0.0 2.5 2 0 0 2 2 2 0 Poxvirus A32 protein ATPase_2 PF01637.18 EXF79990.1 - 0.088 12.7 0.3 4 7.3 0.0 2.8 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea DEAD PF00270.29 EXF79990.1 - 0.11 12.3 1.6 15 5.3 0.1 3.1 3 0 0 3 3 3 0 DEAD/DEAH box helicase AAA_24 PF13479.6 EXF79990.1 - 0.12 12.0 0.6 3.1 7.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain CbiA PF01656.23 EXF79990.1 - 0.19 11.8 0.9 1.4 9.0 0.0 2.5 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain PduV-EutP PF10662.9 EXF79990.1 - 0.28 10.9 4.1 2.2 8.0 0.4 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation dNK PF01712.19 EXF79990.1 - 0.29 11.0 1.2 13 5.6 0.1 2.4 2 0 0 2 2 2 0 Deoxynucleoside kinase cobW PF02492.19 EXF79990.1 - 0.39 10.3 5.5 0.48 10.0 1.5 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain MobB PF03205.14 EXF79990.1 - 1.2 9.1 2.9 4.1 7.3 0.5 2.4 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA PF00004.29 EXF79990.1 - 2.5 8.6 5.6 34 4.9 0.4 3.6 3 1 0 3 3 2 0 ATPase family associated with various cellular activities (AAA) NTPase_1 PF03266.15 EXF79990.1 - 4.3 7.2 12.3 7.9 6.4 0.1 3.9 4 0 0 4 4 4 0 NTPase AAA_19 PF13245.6 EXF79990.1 - 8.7 6.7 8.1 3 8.2 1.6 3.2 3 1 0 3 3 2 0 AAA domain FAD_binding_4 PF01565.23 EXF79992.1 - 8.4e-23 80.6 1.8 1.3e-22 80.0 1.8 1.3 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EXF79992.1 - 0.0045 17.1 0.0 0.0094 16.0 0.0 1.5 1 0 0 1 1 1 1 Berberine and berberine like RRM_1 PF00076.22 EXF79995.1 - 3.9e-46 154.8 0.0 1.5e-16 59.9 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EXF79995.1 - 4e-05 23.5 0.1 0.0025 17.8 0.1 3.0 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 EXF79995.1 - 7.6e-05 22.5 0.0 0.057 13.3 0.0 3.1 3 0 0 3 3 3 1 Occluded RNA-recognition motif RRM_7 PF16367.5 EXF79995.1 - 0.0001 22.3 0.1 0.059 13.5 0.0 3.0 3 0 0 3 3 3 2 RNA recognition motif RRM_3 PF08777.11 EXF79995.1 - 0.00021 21.3 0.0 0.0019 18.2 0.0 2.3 3 0 0 3 3 3 1 RNA binding motif RRM_5 PF13893.6 EXF79995.1 - 0.035 13.7 0.0 0.12 11.9 0.0 1.8 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ecm29 PF13001.7 EXF79996.1 - 5e-126 421.3 0.0 8.1e-125 417.3 0.0 2.8 3 0 0 3 3 3 1 Proteasome stabiliser HEAT PF02985.22 EXF79996.1 - 0.00045 20.3 7.4 2.6 8.5 0.0 7.2 8 0 0 8 8 8 2 HEAT repeat HEAT_2 PF13646.6 EXF79996.1 - 0.0032 17.8 4.2 39 4.7 0.0 7.0 7 0 0 7 7 7 0 HEAT repeats IFRD PF05004.13 EXF79996.1 - 0.053 12.6 0.1 3.3 6.7 0.0 3.7 5 0 0 5 5 5 0 Interferon-related developmental regulator (IFRD) Rpp20 PF12328.8 EXF79996.1 - 0.1 12.6 0.0 0.25 11.3 0.0 1.6 1 0 0 1 1 1 0 Rpp20 subunit of nuclear RNase MRP and P Thioredoxin_7 PF13899.6 EXF79997.1 - 3.7e-17 62.3 0.0 7.1e-17 61.4 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like UBA_4 PF14555.6 EXF79997.1 - 6.1e-16 58.0 0.6 1.3e-15 56.9 0.6 1.6 1 0 0 1 1 1 1 UBA-like domain UBX PF00789.20 EXF79997.1 - 1.8e-06 28.0 0.0 3.3e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 UBX domain Thioredox_DsbH PF03190.15 EXF79997.1 - 0.01 15.8 0.0 0.018 15.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF255 Pkinase PF00069.25 EXF79998.1 - 7.3e-69 232.1 0.0 1.3e-68 231.2 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF79998.1 - 9e-51 172.6 0.0 1.5e-50 171.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EXF79998.1 - 0.0005 19.0 0.0 0.00092 18.1 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EXF79998.1 - 0.031 13.6 0.0 0.073 12.4 0.0 1.5 1 0 0 1 1 1 0 Kinase-like DUF347 PF03988.12 EXF79999.1 - 0.044 14.0 0.0 0.12 12.6 0.0 1.8 1 0 0 1 1 1 0 Repeat of Unknown Function (DUF347) 3-PAP PF12578.8 EXF80000.1 - 0.065 13.0 4.0 0.35 10.6 0.0 2.1 2 0 0 2 2 2 0 Myotubularin-associated protein Pox_A_type_inc PF04508.12 EXF80000.1 - 0.14 12.0 2.6 0.28 11.1 2.6 1.4 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat YqzH PF14164.6 EXF80000.1 - 0.15 12.1 1.5 0.32 11.1 0.0 2.2 3 0 0 3 3 3 0 YqzH-like protein Asp_protease_2 PF13650.6 EXF80001.1 - 2.3e-05 24.9 0.0 5.2e-05 23.8 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 EXF80001.1 - 0.0018 18.8 0.0 0.005 17.4 0.0 1.7 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease HisKA PF00512.25 EXF80001.1 - 0.065 13.3 0.7 1.9 8.6 0.1 2.9 3 0 0 3 3 3 0 His Kinase A (phospho-acceptor) domain BAR_3_WASP_bdg PF10456.9 EXF80001.1 - 0.12 11.8 0.0 0.33 10.4 0.0 1.6 1 1 0 1 1 1 0 WASP-binding domain of Sorting nexin protein MFS_1 PF07690.16 EXF80003.1 - 2.1e-12 46.7 18.3 3.4e-12 46.0 18.3 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily UNC-93 PF05978.16 EXF80003.1 - 0.00033 20.4 1.5 0.00033 20.4 1.5 1.8 2 1 0 2 2 2 1 Ion channel regulatory protein UNC-93 Sugar_tr PF00083.24 EXF80003.1 - 0.00035 19.6 5.1 0.00066 18.7 5.1 1.4 1 0 0 1 1 1 1 Sugar (and other) transporter FMO-like PF00743.19 EXF80004.1 - 3.7e-25 88.3 0.0 5e-11 41.7 0.1 3.1 2 1 1 3 3 3 3 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EXF80004.1 - 2.5e-14 53.2 0.1 7.3e-11 41.9 0.1 3.5 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EXF80004.1 - 2.2e-11 43.5 0.0 7.2e-11 41.8 0.0 1.8 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EXF80004.1 - 1.8e-09 37.2 0.0 6.1e-06 25.6 0.0 2.3 2 0 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 EXF80004.1 - 5.8e-08 32.9 0.0 4e-05 23.6 0.0 2.4 2 0 0 2 2 2 2 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 EXF80004.1 - 3.3e-05 24.0 0.0 8.9e-05 22.7 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EXF80004.1 - 0.00029 20.5 0.2 0.61 9.6 0.1 2.4 2 0 0 2 2 2 2 FAD dependent oxidoreductase Thi4 PF01946.17 EXF80004.1 - 0.046 12.9 0.4 0.09 12.0 0.0 1.6 2 0 0 2 2 2 0 Thi4 family Pyr_redox PF00070.27 EXF80004.1 - 0.051 14.1 0.7 1.8 9.2 0.0 3.0 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase TssN PF17555.2 EXF80006.1 - 0.25 10.7 7.4 0.34 10.2 7.4 1.1 1 0 0 1 1 1 0 Type VI secretion system, TssN Sugar_tr PF00083.24 EXF80007.1 - 9.3e-88 295.1 23.8 1.1e-87 294.8 23.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF80007.1 - 6.3e-19 68.1 46.9 2.4e-17 62.9 21.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EXF80007.1 - 0.0081 14.8 21.9 0.021 13.4 9.4 2.6 2 1 0 2 2 2 2 MFS/sugar transport protein Sterol_MT_C PF08498.10 EXF80008.1 - 5.1e-27 94.0 0.8 9.7e-27 93.1 0.8 1.5 1 0 0 1 1 1 1 Sterol methyltransferase C-terminal Methyltransf_11 PF08241.12 EXF80008.1 - 6.6e-23 81.2 0.0 1.3e-22 80.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF80008.1 - 6.1e-21 74.9 0.0 1.4e-20 73.7 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF80008.1 - 2.1e-20 73.1 0.0 3.2e-20 72.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EXF80008.1 - 1.4e-15 57.5 0.0 2.9e-15 56.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EXF80008.1 - 1.1e-13 51.1 0.0 1.9e-13 50.3 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family CMAS PF02353.20 EXF80008.1 - 8.6e-12 44.9 0.1 1.3e-11 44.3 0.1 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_12 PF08242.12 EXF80008.1 - 4.7e-11 43.3 0.1 1.4e-10 41.8 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain PrmA PF06325.13 EXF80008.1 - 3.3e-05 23.4 0.1 0.00013 21.4 0.0 1.8 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) PCMT PF01135.19 EXF80008.1 - 3.7e-05 23.6 0.0 6e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_2 PF00891.18 EXF80008.1 - 0.00032 20.1 0.1 0.00046 19.5 0.1 1.4 1 0 0 1 1 1 1 O-methyltransferase domain MTS PF05175.14 EXF80008.1 - 0.00035 20.2 0.0 0.00061 19.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_32 PF13679.6 EXF80008.1 - 0.00091 19.2 0.3 0.0017 18.4 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_8 PF05148.15 EXF80008.1 - 0.0011 18.9 0.0 0.0032 17.4 0.0 1.8 1 1 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_29 PF03141.16 EXF80008.1 - 0.0034 16.0 0.0 0.0052 15.4 0.0 1.2 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase MetW PF07021.12 EXF80008.1 - 0.0077 15.8 0.0 0.014 15.0 0.0 1.4 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_15 PF09445.10 EXF80008.1 - 0.0097 15.5 0.0 0.015 14.9 0.0 1.3 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase RrnaAD PF00398.20 EXF80008.1 - 0.02 14.0 0.0 0.03 13.4 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Pec_lyase_C PF00544.19 EXF80009.1 - 1e-25 90.6 8.0 9.4e-21 74.4 1.0 2.1 1 1 1 2 2 2 2 Pectate lyase Beta_helix PF13229.6 EXF80009.1 - 0.00035 20.4 4.7 0.00071 19.4 4.4 1.5 1 1 0 1 1 1 1 Right handed beta helix region COesterase PF00135.28 EXF80010.1 - 3.8e-82 276.8 0.0 5.3e-82 276.3 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EXF80010.1 - 0.00049 20.0 0.1 0.0027 17.6 0.1 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Aldo_ket_red PF00248.21 EXF80011.1 - 2e-66 224.2 0.0 2.6e-66 223.8 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Methyltransf_11 PF08241.12 EXF80014.1 - 2.4e-20 73.0 0.0 5e-20 72.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF80014.1 - 2.9e-19 69.6 0.0 6e-19 68.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF80014.1 - 3.7e-17 62.5 0.0 5.5e-17 62.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EXF80014.1 - 9.1e-13 48.4 0.0 1.4e-12 47.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EXF80014.1 - 4.3e-11 42.6 0.0 5.8e-11 42.2 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_12 PF08242.12 EXF80014.1 - 8.4e-11 42.5 0.0 1.7e-10 41.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EXF80014.1 - 1.8e-10 40.6 0.0 6e-10 38.8 0.0 1.8 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family MetW PF07021.12 EXF80014.1 - 2.5e-05 24.0 0.0 4.1e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW MTS PF05175.14 EXF80014.1 - 5e-05 22.9 0.0 7.8e-05 22.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain TehB PF03848.14 EXF80014.1 - 0.00062 19.2 0.0 0.0015 17.9 0.0 1.6 2 0 0 2 2 2 1 Tellurite resistance protein TehB PrmA PF06325.13 EXF80014.1 - 0.00066 19.2 0.0 0.00097 18.6 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) PCMT PF01135.19 EXF80014.1 - 0.0011 18.8 0.0 0.0018 18.1 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_4 PF02390.17 EXF80014.1 - 0.022 14.2 0.0 0.062 12.8 0.0 1.7 2 0 0 2 2 2 0 Putative methyltransferase Methyltransf_32 PF13679.6 EXF80014.1 - 0.042 13.8 0.0 0.081 12.9 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain DOT1 PF08123.13 EXF80014.1 - 0.075 12.5 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 Histone methylation protein DOT1 DREV PF05219.12 EXF80014.1 - 0.11 11.5 0.0 0.19 10.8 0.0 1.3 1 0 0 1 1 1 0 DREV methyltransferase Methyltr_RsmB-F PF01189.17 EXF80014.1 - 0.13 11.9 0.0 0.21 11.2 0.0 1.3 1 0 0 1 1 1 0 16S rRNA methyltransferase RsmB/F Iso_dh PF00180.20 EXF80016.1 - 3e-82 276.5 0.1 3.5e-82 276.4 0.1 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase p450 PF00067.22 EXF80017.1 - 4.9e-60 203.6 0.0 6.1e-60 203.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 NAAA-beta PF15508.6 EXF80018.1 - 2.9e-12 46.7 0.0 5e-12 45.9 0.0 1.4 1 0 0 1 1 1 1 beta subunit of N-acylethanolamine-hydrolyzing acid amidase Toxin_22 PF08092.11 EXF80019.1 - 0.21 11.7 2.6 13 5.9 0.1 2.4 2 0 0 2 2 2 0 Magi peptide toxin family Acetyltransf_10 PF13673.7 EXF80020.1 - 0.17 11.8 0.0 0.28 11.1 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain ADH_zinc_N PF00107.26 EXF80021.1 - 3.3e-20 72.4 0.0 5e-20 71.8 0.0 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 EXF80021.1 - 2.9e-19 68.9 0.0 1.2e-18 67.0 0.0 1.9 2 0 0 2 2 2 1 N-terminal domain of oxidoreductase ADH_zinc_N_2 PF13602.6 EXF80021.1 - 3.9e-09 37.6 0.0 7.3e-09 36.8 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Dynamin_N PF00350.23 EXF80022.1 - 1e-31 110.3 0.0 2.5e-31 109.0 0.0 1.7 1 0 0 1 1 1 1 Dynamin family Dynamin_M PF01031.20 EXF80022.1 - 4.1e-15 55.8 0.0 3.1e-14 52.9 0.0 2.2 1 1 0 1 1 1 1 Dynamin central region MMR_HSR1 PF01926.23 EXF80022.1 - 2.2e-05 24.5 0.1 8.3e-05 22.6 0.0 2.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase ABC_tran PF00005.27 EXF80022.1 - 0.051 14.1 0.0 0.18 12.3 0.0 1.9 1 0 0 1 1 1 0 ABC transporter VPS13_C PF16909.5 EXF80022.1 - 0.15 11.8 0.0 0.29 10.9 0.0 1.4 1 0 0 1 1 1 0 Vacuolar-sorting-associated 13 protein C-terminal AAA_15 PF13175.6 EXF80022.1 - 0.23 11.1 1.4 0.98 9.1 0.0 2.3 2 0 0 2 2 2 0 AAA ATPase domain Hydin_ADK PF17213.3 EXF80022.1 - 0.82 9.9 5.2 2.1 8.6 5.2 1.7 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain adh_short PF00106.25 EXF80023.1 - 1.5e-23 83.3 0.0 3.6e-19 69.0 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EXF80023.1 - 3e-13 49.9 0.0 1.8e-12 47.3 0.0 1.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Polysacc_synt_2 PF02719.15 EXF80023.1 - 0.039 13.1 0.0 0.054 12.6 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Shikimate_DH PF01488.20 EXF80023.1 - 0.11 12.6 0.0 0.44 10.6 0.0 1.9 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Erv26 PF04148.13 EXF80025.1 - 4.7e-93 310.7 3.5 5.8e-93 310.4 3.5 1.1 1 0 0 1 1 1 1 Transmembrane adaptor Erv26 Cytochrom_C_asm PF01578.20 EXF80025.1 - 0.0045 16.8 0.2 0.0045 16.8 0.2 1.6 3 0 0 3 3 3 1 Cytochrome C assembly protein DUF3377 PF11857.8 EXF80025.1 - 0.019 14.9 0.4 0.55 10.2 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3377) DUF996 PF06195.13 EXF80025.1 - 0.019 15.2 0.9 0.034 14.4 0.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF996) WBS_methylT PF12589.8 EXF80026.1 - 1.8e-16 60.7 6.9 3.3e-16 59.8 6.9 1.5 1 0 0 1 1 1 1 Methyltransferase involved in Williams-Beuren syndrome Methyltransf_11 PF08241.12 EXF80026.1 - 6.3e-12 46.0 0.0 1.2e-11 45.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF80026.1 - 6.9e-11 42.7 0.0 1.9e-10 41.3 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF80026.1 - 1.8e-05 25.4 0.0 8.1e-05 23.3 0.0 2.2 2 1 0 2 2 2 1 Methyltransferase domain PCMT PF01135.19 EXF80026.1 - 0.00085 19.1 0.0 0.0014 18.4 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 EXF80026.1 - 0.001 18.9 0.0 0.0015 18.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EXF80026.1 - 0.0024 17.2 0.0 0.056 12.7 0.0 2.1 2 0 0 2 2 2 1 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.6 EXF80026.1 - 0.0024 17.7 0.0 0.0038 17.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EXF80026.1 - 0.036 13.4 0.0 0.11 11.8 0.0 1.8 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family Methyltransf_2 PF00891.18 EXF80026.1 - 0.092 12.0 0.0 0.17 11.1 0.0 1.4 1 0 0 1 1 1 0 O-methyltransferase domain p450 PF00067.22 EXF80027.1 - 5.5e-69 233.1 0.0 7e-69 232.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Inhibitor_I9 PF05922.16 EXF80028.1 - 0.011 16.3 0.0 0.024 15.3 0.0 1.5 1 0 0 1 1 1 0 Peptidase inhibitor I9 HET PF06985.11 EXF80029.1 - 7.6e-37 126.9 0.6 1.3e-36 126.2 0.6 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) ADC PF06314.11 EXF80030.1 - 0.00026 20.6 0.0 0.00041 20.0 0.0 1.3 1 0 0 1 1 1 1 Acetoacetate decarboxylase (ADC) HET PF06985.11 EXF80031.1 - 1.1e-25 90.7 0.8 2e-25 89.8 0.2 1.8 2 0 0 2 2 2 1 Heterokaryon incompatibility protein (HET) AIMP2_LysRS_bd PF16780.5 EXF80031.1 - 0.0054 16.4 0.0 0.04 13.7 0.0 2.2 2 0 0 2 2 2 1 AIMP2 lysyl-tRNA synthetase binding domain Abhydrolase_6 PF12697.7 EXF80032.1 - 1.3e-17 65.2 0.0 1.6e-17 64.8 0.0 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF900 PF05990.12 EXF80032.1 - 0.0098 15.4 0.0 0.024 14.2 0.0 1.5 2 0 0 2 2 2 1 Alpha/beta hydrolase of unknown function (DUF900) Hydrolase_4 PF12146.8 EXF80032.1 - 0.063 12.5 0.0 0.074 12.3 0.0 1.3 1 1 0 1 1 1 0 Serine aminopeptidase, S33 Abhydrolase_8 PF06259.12 EXF80032.1 - 0.093 12.4 0.0 0.17 11.5 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase DUF676 PF05057.14 EXF80032.1 - 0.22 11.0 0.0 0.28 10.7 0.0 1.2 1 0 0 1 1 1 0 Putative serine esterase (DUF676) BCS1_N PF08740.11 EXF80033.1 - 4.2e-36 124.7 1.0 4.5e-36 124.6 0.1 1.5 2 0 0 2 2 2 1 BCS1 N terminal AAA PF00004.29 EXF80033.1 - 6.9e-14 52.4 0.0 4.3e-13 49.8 0.0 2.2 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EXF80033.1 - 8.9e-06 25.5 0.0 1.6e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_11 PF13086.6 EXF80033.1 - 0.007 16.2 1.6 0.28 10.9 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EXF80033.1 - 0.02 15.3 0.4 0.07 13.5 0.0 2.2 2 1 0 2 2 2 0 AAA ATPase domain AAA_5 PF07728.14 EXF80033.1 - 0.041 13.9 0.0 0.13 12.2 0.0 2.0 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 EXF80033.1 - 0.045 14.3 0.4 0.29 11.7 0.0 2.3 1 1 1 2 2 2 0 AAA domain AAA_24 PF13479.6 EXF80033.1 - 0.051 13.3 0.3 1.8 8.2 0.1 2.5 1 1 1 2 2 2 0 AAA domain ATPase PF06745.13 EXF80033.1 - 0.052 12.9 0.0 0.11 11.8 0.0 1.5 1 0 0 1 1 1 0 KaiC IstB_IS21 PF01695.17 EXF80033.1 - 0.096 12.4 0.0 0.2 11.4 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein Hydin_ADK PF17213.3 EXF80033.1 - 0.17 12.1 7.0 19 5.5 6.1 2.3 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain AAA_28 PF13521.6 EXF80033.1 - 0.2 11.9 1.1 0.58 10.4 0.0 2.3 3 0 0 3 3 3 0 AAA domain Glyco_hydro_76 PF03663.14 EXF80034.1 - 3.4e-122 408.5 8.8 4.1e-122 408.2 8.8 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Fungal_trans_2 PF11951.8 EXF80036.1 - 1e-07 31.1 0.0 1.4e-07 30.7 0.0 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF80036.1 - 0.0003 20.8 1.2 0.00053 20.0 1.2 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain XK-related PF09815.9 EXF80037.1 - 3 6.8 14.6 0.53 9.3 8.9 1.9 1 1 1 2 2 2 0 XK-related protein MFS_1 PF07690.16 EXF80038.1 - 1.1e-29 103.5 27.3 1.1e-29 103.5 27.3 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily DivIC PF04977.15 EXF80038.1 - 0.066 13.0 0.0 0.16 11.8 0.0 1.6 1 0 0 1 1 1 0 Septum formation initiator PhoLip_ATPase_C PF16212.5 EXF80038.1 - 1.7 8.3 11.8 0.081 12.7 4.2 2.5 3 0 0 3 3 3 0 Phospholipid-translocating P-type ATPase C-terminal Fungal_trans_2 PF11951.8 EXF80039.1 - 0.0011 17.9 2.9 0.0018 17.2 2.9 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain DLH PF01738.18 EXF80040.1 - 1e-24 87.3 0.0 1.4e-24 86.9 0.0 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_1 PF00561.20 EXF80040.1 - 1.6e-05 24.7 0.0 7.1e-05 22.6 0.0 1.8 2 0 0 2 2 2 1 alpha/beta hydrolase fold Chlorophyllase PF07224.11 EXF80040.1 - 0.0011 18.0 0.0 0.0015 17.6 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase MFS_1 PF07690.16 EXF80041.1 - 1.8e-35 122.6 55.5 4.5e-26 91.6 32.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2304 PF10066.9 EXF80041.1 - 0.36 11.1 1.8 0.77 10.0 0.2 2.4 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2304) Glyco_hydro_7 PF00840.20 EXF80042.1 - 6.4e-186 618.3 9.1 7.3e-186 618.1 9.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 7 Gamma-thionin PF00304.20 EXF80042.1 - 0.022 15.0 0.7 0.022 15.0 0.7 3.1 4 0 0 4 4 4 0 Gamma-thionin family DUF5013 PF16405.5 EXF80042.1 - 0.075 13.3 0.4 0.14 12.4 0.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5013) DUF3425 PF11905.8 EXF80043.1 - 7.5e-24 84.1 0.0 1.3e-23 83.3 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) EABR PF12180.8 EXF80043.1 - 0.2 11.3 0.0 0.35 10.5 0.0 1.4 1 0 0 1 1 1 0 TSG101 and ALIX binding domain of CEP55 Tannase PF07519.11 EXF80044.1 - 6.5e-78 262.7 0.3 1.2e-77 261.8 0.3 1.4 1 0 0 1 1 1 1 Tannase and feruloyl esterase Abhydrolase_1 PF00561.20 EXF80044.1 - 2.5e-18 66.7 0.1 9.5e-15 54.9 0.0 2.4 2 0 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EXF80044.1 - 3.2e-08 33.1 0.0 0.00015 21.2 0.0 2.4 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EXF80044.1 - 2.7e-07 31.4 0.0 2.9e-06 28.0 0.0 2.6 3 0 0 3 3 3 1 Alpha/beta hydrolase family Fungal_trans_2 PF11951.8 EXF80044.1 - 5.3e-06 25.5 0.0 8e-06 24.9 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Esterase PF00756.20 EXF80044.1 - 1.2e-05 25.1 0.1 0.011 15.4 0.0 2.4 2 0 0 2 2 2 2 Putative esterase Peptidase_S9 PF00326.21 EXF80044.1 - 0.00018 21.0 0.0 0.29 10.6 0.0 3.2 3 0 0 3 3 3 2 Prolyl oligopeptidase family Peptidase_S28 PF05577.12 EXF80044.1 - 0.061 12.1 0.0 0.095 11.5 0.0 1.2 1 0 0 1 1 1 0 Serine carboxypeptidase S28 Zn_clus PF00172.18 EXF80044.1 - 0.82 9.8 2.8 1.7 8.8 2.8 1.5 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Abhydrolase_4 PF08386.10 EXF80046.1 - 1.3e-17 63.8 0.0 2.8e-17 62.7 0.0 1.6 1 0 0 1 1 1 1 TAP-like protein ADH_zinc_N PF00107.26 EXF80046.1 - 1.7e-13 50.6 0.0 5.2e-13 49.1 0.0 1.8 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Abhydrolase_1 PF00561.20 EXF80046.1 - 3.1e-09 36.8 0.0 1.1e-07 31.7 0.0 2.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold ADH_zinc_N_2 PF13602.6 EXF80046.1 - 8.3e-06 26.9 0.0 3.2e-05 25.0 0.0 2.1 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EXF80046.1 - 4.3e-05 23.3 0.1 0.0002 21.2 0.0 2.2 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain Epimerase PF01370.21 EXF80046.1 - 0.04 13.4 0.0 0.13 11.7 0.0 1.7 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family MLTR_LBD PF17765.1 EXF80046.1 - 0.11 12.6 0.3 30 4.7 0.1 3.2 3 0 0 3 3 3 0 MmyB-like transcription regulator ligand binding domain MFS_1 PF07690.16 EXF80047.1 - 1.3e-20 73.7 56.4 2.4e-11 43.2 42.3 2.5 1 1 1 2 2 2 2 Major Facilitator Superfamily Csd3_N PF18059.1 EXF80047.1 - 0.055 14.0 0.0 0.11 13.0 0.0 1.4 1 0 0 1 1 1 0 Csd3 N-terminal PolyG_pol PF01518.16 EXF80047.1 - 0.089 11.5 0.1 0.15 10.8 0.1 1.3 1 0 0 1 1 1 0 Sigma NS protein M20_dimer PF07687.14 EXF80048.1 - 0.14 12.1 0.0 0.22 11.4 0.0 1.3 1 0 0 1 1 1 0 Peptidase dimerisation domain OPT PF03169.15 EXF80049.1 - 4.4e-163 544.2 43.0 5e-163 544.0 43.0 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Epimerase PF01370.21 EXF80050.1 - 1.6e-10 40.8 0.0 8.5e-10 38.5 0.0 2.1 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EXF80050.1 - 2.2e-06 26.9 0.0 3.4e-06 26.3 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 EXF80050.1 - 4.4e-06 26.1 0.0 0.00024 20.4 0.0 2.2 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.6 EXF80050.1 - 5e-06 26.5 0.0 7.5e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 EXF80050.1 - 7.3e-06 25.6 0.1 2.4e-05 23.9 0.0 1.9 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase NmrA PF05368.13 EXF80050.1 - 8.1e-05 22.3 0.0 0.00011 21.8 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family adh_short PF00106.25 EXF80050.1 - 0.088 12.3 0.0 0.27 10.7 0.0 1.8 2 0 0 2 2 2 0 short chain dehydrogenase RmlD_sub_bind PF04321.17 EXF80050.1 - 0.15 11.1 0.6 0.53 9.3 0.0 2.1 3 0 0 3 3 3 0 RmlD substrate binding domain KR PF08659.10 EXF80050.1 - 0.15 11.9 0.1 22 4.9 0.0 2.3 2 0 0 2 2 2 0 KR domain Meth_synt_2 PF01717.18 EXF80051.1 - 4.2e-09 36.1 0.0 7.9e-08 31.9 0.0 2.5 2 1 0 2 2 2 1 Cobalamin-independent synthase, Catalytic domain Meth_synt_1 PF08267.12 EXF80051.1 - 0.0021 17.6 0.1 0.0078 15.8 0.0 1.9 3 0 0 3 3 3 1 Cobalamin-independent synthase, N-terminal domain RGS PF00615.19 EXF80052.1 - 0.00019 21.7 0.0 0.00076 19.7 0.0 1.9 1 1 0 1 1 1 1 Regulator of G protein signaling domain DUF4381 PF14316.6 EXF80053.1 - 0.03 14.6 0.8 0.045 14.0 0.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) UPF0370 PF13980.6 EXF80053.1 - 0.07 13.2 2.8 0.11 12.6 2.8 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0370) RCR PF12273.8 EXF80053.1 - 0.39 11.4 3.6 0.87 10.3 3.6 1.7 1 1 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red DUF4231 PF14015.6 EXF80053.1 - 1.5 9.3 4.5 3.3 8.2 4.5 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF4231) Methyltransf_25 PF13649.6 EXF80054.1 - 1.6e-05 25.5 0.0 3.7e-05 24.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF80054.1 - 3.9e-05 24.3 0.0 6.5e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF80054.1 - 0.00047 20.0 0.0 0.00064 19.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EXF80054.1 - 0.0007 19.5 0.0 0.001 18.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF80054.1 - 0.06 14.0 0.0 0.11 13.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain hDGE_amylase PF14701.6 EXF80055.1 - 4.5e-180 599.4 0.0 5.8e-180 599.1 0.0 1.1 1 0 0 1 1 1 1 Glycogen debranching enzyme, glucanotransferase domain GDE_C PF06202.14 EXF80055.1 - 6.1e-117 390.8 0.2 1.1e-116 390.0 0.0 1.5 2 0 0 2 2 2 1 Amylo-alpha-1,6-glucosidase hGDE_central PF14702.6 EXF80055.1 - 2.5e-89 299.3 0.0 1.2e-88 297.0 0.0 2.1 2 0 0 2 2 2 1 Central domain of human glycogen debranching enzyme hGDE_N PF14699.6 EXF80055.1 - 1.9e-30 104.9 0.0 4.9e-30 103.5 0.0 1.8 1 0 0 1 1 1 1 N-terminal domain from the human glycogen debranching enzyme NAD_Gly3P_dh_N PF01210.23 EXF80056.1 - 8.5e-46 155.8 0.0 5.9e-45 153.0 0.0 2.0 2 0 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_Gly3P_dh_C PF07479.14 EXF80056.1 - 6.4e-42 143.2 0.1 1.1e-41 142.4 0.1 1.3 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus HABP4_PAI-RBP1 PF04774.15 EXF80056.1 - 0.21 12.4 0.0 0.43 11.4 0.0 1.5 1 0 0 1 1 1 0 Hyaluronan / mRNA binding family AIG2_2 PF13772.6 EXF80057.1 - 3e-05 24.3 0.0 0.00036 20.9 0.0 2.4 2 0 0 2 2 2 1 AIG2-like family Chromo PF00385.24 EXF80058.1 - 2.8e-07 30.3 0.0 1.3e-05 25.0 0.0 2.4 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain DNA_pol_alpha_N PF12254.8 EXF80058.1 - 0.31 11.2 3.3 0.85 9.7 0.8 2.5 2 0 0 2 2 2 0 DNA polymerase alpha subunit p180 N terminal SAT PF16073.5 EXF80059.1 - 7.2e-76 255.1 0.2 7.2e-76 255.1 0.2 2.4 3 0 0 3 3 3 1 Starter unit:ACP transacylase in aflatoxin biosynthesis ketoacyl-synt PF00109.26 EXF80059.1 - 9.7e-75 251.4 0.0 2e-74 250.4 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 EXF80059.1 - 1.6e-45 156.0 0.0 2.8e-45 155.2 0.0 1.4 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EXF80059.1 - 1.8e-36 124.8 2.1 2e-36 124.6 0.6 2.0 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain Thioesterase PF00975.20 EXF80059.1 - 2.4e-23 83.4 0.0 1.1e-22 81.3 0.0 2.2 2 1 0 2 2 2 1 Thioesterase domain PP-binding PF00550.25 EXF80059.1 - 2.6e-21 75.7 3.0 7.3e-11 42.3 0.2 2.6 2 0 0 2 2 2 2 Phosphopantetheine attachment site PS-DH PF14765.6 EXF80059.1 - 1.3e-20 73.8 0.0 2.3e-20 73.1 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase Thiolase_N PF00108.23 EXF80059.1 - 0.00025 20.5 0.0 0.0012 18.3 0.0 2.1 2 0 0 2 2 2 1 Thiolase, N-terminal domain KAsynt_C_assoc PF16197.5 EXF80059.1 - 0.00043 20.7 0.0 0.0011 19.4 0.0 1.7 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Hydrolase_4 PF12146.8 EXF80059.1 - 0.01 15.1 0.3 0.13 11.5 0.0 2.3 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Ribosomal_60s PF00428.19 EXF80059.1 - 1.1 9.9 12.9 1.6 9.3 7.8 3.1 2 0 0 2 2 2 0 60s Acidic ribosomal protein Cu-oxidase_3 PF07732.15 EXF80060.1 - 1.2e-44 151.1 8.8 1.4e-39 134.8 1.9 4.2 4 0 0 4 4 4 3 Multicopper oxidase Cu-oxidase_2 PF07731.14 EXF80060.1 - 1.8e-40 137.9 13.7 3.1e-37 127.3 2.6 3.8 3 1 0 3 3 3 3 Multicopper oxidase Cu-oxidase PF00394.22 EXF80060.1 - 2.8e-25 89.3 2.7 4.3e-23 82.2 0.0 3.0 3 1 0 3 3 3 2 Multicopper oxidase Defensin_like PF10868.8 EXF80061.1 - 0.022 15.5 14.5 0.03 15.0 14.5 1.3 1 0 0 1 1 1 0 Cysteine-rich antifungal protein 2, defensin-like DUF4033 PF13225.6 EXF80061.1 - 0.032 14.2 2.0 0.036 14.1 2.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4033) Oxysterol_BP PF01237.18 EXF80062.1 - 6.9e-110 367.4 0.0 1.4e-109 366.3 0.0 1.5 1 1 0 1 1 1 1 Oxysterol-binding protein PH_8 PF15409.6 EXF80062.1 - 8.5e-39 131.7 1.1 4.5e-38 129.4 0.2 2.3 2 0 0 2 2 2 1 Pleckstrin homology domain PH PF00169.29 EXF80062.1 - 8.4e-08 32.7 0.0 2.3e-07 31.2 0.0 1.8 1 0 0 1 1 1 1 PH domain PH_17 PF18012.1 EXF80062.1 - 0.17 11.6 0.3 0.75 9.6 0.3 2.1 2 0 0 2 2 2 0 PH domain Ribosomal_L27e PF01777.18 EXF80062.1 - 0.23 11.8 0.8 15 6.0 0.0 2.6 2 0 0 2 2 2 0 Ribosomal L27e protein family HEPN_SAV_6107 PF18726.1 EXF80062.1 - 0.52 10.9 5.1 0.26 11.8 0.6 2.7 2 0 0 2 2 2 0 SAV_6107-like HEPN ArfGap PF01412.18 EXF80063.1 - 3.9e-38 130.1 0.2 3.9e-38 130.1 0.2 1.9 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf UBA PF00627.31 EXF80063.1 - 0.15 12.0 0.0 0.38 10.7 0.0 1.8 1 0 0 1 1 1 0 UBA/TS-N domain Foie-gras_1 PF11817.8 EXF80063.1 - 4.4 6.8 13.1 9.8 5.7 13.1 1.5 1 0 0 1 1 1 0 Foie gras liver health family 1 Pyridoxal_deC PF00282.19 EXF80064.1 - 2.4e-25 89.1 0.0 3.3e-25 88.6 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Beta_elim_lyase PF01212.21 EXF80064.1 - 0.00067 19.0 0.0 0.00088 18.6 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.21 EXF80064.1 - 0.0014 17.9 0.0 0.0022 17.3 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II DUF92 PF01940.16 EXF80065.1 - 1.1e-89 300.0 1.9 1.4e-89 299.6 1.9 1.1 1 0 0 1 1 1 1 Integral membrane protein DUF92 Mito_carr PF00153.27 EXF80066.1 - 4.1e-53 177.3 0.3 2.1e-17 62.8 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Ribosomal_L22e PF01776.17 EXF80067.1 - 5.3e-46 155.5 1.7 6.8e-46 155.1 1.7 1.1 1 0 0 1 1 1 1 Ribosomal L22e protein family DUF3568 PF12092.8 EXF80067.1 - 0.086 12.9 1.1 0.11 12.5 0.6 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3568) NmrA PF05368.13 EXF80068.1 - 7.5e-09 35.5 0.0 5.1e-07 29.5 0.0 2.1 2 0 0 2 2 2 1 NmrA-like family NAD_binding_10 PF13460.6 EXF80068.1 - 4.1e-08 33.3 0.1 8.9e-07 29.0 0.1 2.3 1 1 0 1 1 1 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 EXF80068.1 - 6.3e-05 23.2 0.0 0.0001 22.6 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_7 PF13241.6 EXF80068.1 - 0.00029 21.2 0.0 0.00054 20.4 0.0 1.4 1 0 0 1 1 1 1 Putative NAD(P)-binding TrkA_N PF02254.18 EXF80068.1 - 0.0034 17.6 0.1 0.0055 17.0 0.1 1.3 1 0 0 1 1 1 1 TrkA-N domain Shikimate_DH PF01488.20 EXF80068.1 - 0.01 15.9 0.1 0.017 15.2 0.1 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.17 EXF80068.1 - 0.057 14.0 0.1 0.13 12.8 0.1 1.7 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent NAD_Gly3P_dh_N PF01210.23 EXF80068.1 - 0.092 12.7 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus ApbA PF02558.16 EXF80068.1 - 0.15 11.7 0.1 0.34 10.5 0.1 1.7 1 1 0 1 1 1 0 Ketopantoate reductase PanE/ApbA A_deaminase PF00962.22 EXF80069.1 - 2.4e-23 83.0 0.0 4.1e-23 82.2 0.0 1.4 1 0 0 1 1 1 1 Adenosine/AMP deaminase DUF2462 PF09495.10 EXF80070.1 - 4.8e-16 59.2 11.5 4.8e-16 59.2 11.5 1.8 1 1 1 2 2 2 1 Protein of unknown function (DUF2462) ketoacyl-synt PF00109.26 EXF80071.1 - 4.5e-74 249.2 0.0 1.1e-73 248.0 0.0 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain AMP-binding PF00501.28 EXF80071.1 - 7.8e-74 248.8 0.0 1.2e-73 248.1 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme Condensation PF00668.20 EXF80071.1 - 4.1e-67 226.8 0.0 5.9e-67 226.3 0.0 1.2 1 0 0 1 1 1 1 Condensation domain KR PF08659.10 EXF80071.1 - 1.2e-58 198.0 8.0 1.8e-57 194.2 0.3 4.2 4 0 0 4 4 4 1 KR domain PS-DH PF14765.6 EXF80071.1 - 3.2e-57 194.0 0.0 6.3e-57 193.1 0.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 EXF80071.1 - 1.6e-56 192.2 0.0 2.8e-56 191.3 0.0 1.4 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EXF80071.1 - 9.9e-40 135.2 0.0 9.1e-39 132.1 0.0 2.5 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain NAD_binding_4 PF07993.12 EXF80071.1 - 3.1e-38 131.4 0.0 6.8e-38 130.3 0.0 1.6 1 0 0 1 1 1 1 Male sterility protein KAsynt_C_assoc PF16197.5 EXF80071.1 - 7.1e-21 74.8 0.0 1.6e-20 73.6 0.0 1.6 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension PP-binding PF00550.25 EXF80071.1 - 7.1e-16 58.3 0.0 1.3e-06 28.7 0.0 3.1 2 0 0 2 2 2 2 Phosphopantetheine attachment site ADH_zinc_N PF00107.26 EXF80071.1 - 1.5e-14 54.1 1.4 4.2e-14 52.6 0.2 2.4 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EXF80071.1 - 2.8e-13 51.1 0.0 1.2e-12 49.0 0.0 2.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase adh_short PF00106.25 EXF80071.1 - 5.4e-10 39.1 4.1 1.5e-09 37.6 0.4 2.7 2 0 0 2 2 2 1 short chain dehydrogenase ADH_N PF08240.12 EXF80071.1 - 3.6e-05 23.6 0.0 9.9e-05 22.2 0.0 1.7 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain 3Beta_HSD PF01073.19 EXF80071.1 - 0.0041 16.2 0.0 0.15 11.0 0.0 2.4 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Thiolase_N PF00108.23 EXF80071.1 - 0.026 13.9 0.0 0.097 12.0 0.0 1.9 1 0 0 1 1 1 0 Thiolase, N-terminal domain SAT PF16073.5 EXF80071.1 - 0.027 14.2 0.3 0.54 9.9 0.3 2.6 1 1 0 1 1 1 0 Starter unit:ACP transacylase in aflatoxin biosynthesis AMP-binding_C PF13193.6 EXF80071.1 - 0.042 14.8 0.0 0.11 13.5 0.0 1.8 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain eIF2A PF08662.11 EXF80071.1 - 0.079 12.8 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 Eukaryotic translation initiation factor eIF2A NAD_binding_10 PF13460.6 EXF80074.1 - 0.19 11.6 0.0 0.77 9.6 0.0 1.8 2 0 0 2 2 2 0 NAD(P)H-binding ADH_zinc_N PF00107.26 EXF80076.1 - 7.1e-11 42.2 0.0 1.4e-10 41.3 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EXF80076.1 - 1.1e-06 28.5 1.0 7e-06 25.9 0.6 2.2 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 EXF80076.1 - 0.057 14.5 0.0 0.12 13.4 0.0 1.5 1 0 0 1 1 1 0 Zinc-binding dehydrogenase zf-C2H2 PF00096.26 EXF80077.1 - 4.1e-13 49.0 11.4 3.4e-06 27.2 2.4 3.6 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EXF80077.1 - 2e-10 40.6 16.5 1.8e-07 31.3 0.2 4.0 4 0 0 4 4 3 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 EXF80077.1 - 6.4e-09 35.9 10.4 0.00039 21.0 1.5 4.0 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EXF80077.1 - 2e-08 34.0 5.4 0.00031 20.7 0.3 3.8 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EXF80077.1 - 2.5e-06 27.6 0.4 0.084 13.2 0.1 3.6 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EXF80077.1 - 2.4e-05 24.6 0.8 0.013 15.9 0.2 3.4 3 0 0 3 3 3 1 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.5 EXF80077.1 - 0.0044 16.8 7.7 0.39 10.5 0.7 4.2 4 0 0 4 4 4 1 zinc-finger C2H2-type PG_binding_2 PF08823.11 EXF80077.1 - 0.078 13.3 0.1 0.21 11.9 0.1 1.6 1 0 0 1 1 1 0 Putative peptidoglycan binding domain zf-Di19 PF05605.12 EXF80077.1 - 0.09 13.1 1.4 0.17 12.2 1.4 1.4 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding Zn_ribbon_recom PF13408.6 EXF80077.1 - 0.096 13.2 0.8 0.23 12.0 0.8 1.6 1 0 0 1 1 1 0 Recombinase zinc beta ribbon domain zf-C2HE PF16278.5 EXF80077.1 - 0.28 11.7 2.6 6.4 7.3 0.4 2.5 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger LIM PF00412.22 EXF80077.1 - 0.29 11.4 3.1 17 5.8 0.1 2.4 1 1 0 2 2 2 0 LIM domain C5HCH PF17982.1 EXF80077.1 - 4.2 7.6 6.2 29 4.9 1.3 2.5 1 1 1 2 2 2 0 NSD Cys-His rich domain AOX PF01786.17 EXF80078.1 - 5e-84 281.2 0.0 6.4e-84 280.8 0.0 1.1 1 0 0 1 1 1 1 Alternative oxidase eIF3_subunit PF08597.10 EXF80080.1 - 3.2e-69 233.5 23.4 3.8e-69 233.3 23.4 1.0 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit Anillin_N PF16018.5 EXF80080.1 - 0.01 16.5 0.2 0.01 16.5 0.2 3.2 2 1 2 4 4 4 0 Anillin N-terminus DUF572 PF04502.13 EXF80080.1 - 0.11 12.1 17.6 0.16 11.5 17.6 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) PRP4 PF08799.11 EXF80080.1 - 0.75 9.4 5.3 1.6 8.3 5.3 1.6 1 0 0 1 1 1 0 pre-mRNA processing factor 4 (PRP4) like CDC45 PF02724.14 EXF80080.1 - 3.1 6.0 13.7 4.7 5.4 13.7 1.3 1 0 0 1 1 1 0 CDC45-like protein APG6_N PF17675.1 EXF80080.1 - 3.7 8.1 22.5 2.9 8.4 18.0 2.2 2 0 0 2 2 2 0 Apg6 coiled-coil region EMG1 PF03587.14 EXF80081.1 - 8.5e-79 263.7 0.0 1e-78 263.5 0.0 1.0 1 0 0 1 1 1 1 EMG1/NEP1 methyltransferase PT PF04886.12 EXF80082.1 - 9.1e-07 28.3 28.0 0.027 14.0 4.7 4.6 1 1 1 2 2 2 2 PT repeat Gly-zipper_Omp PF13488.6 EXF80082.1 - 0.00083 19.3 6.9 0.0016 18.4 6.9 1.4 1 0 0 1 1 1 1 Glycine zipper Cys_Met_Meta_PP PF01053.20 EXF80083.1 - 1.9e-31 109.0 0.0 2.6e-31 108.5 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme SPX PF03105.19 EXF80084.1 - 4.5e-67 227.6 0.2 5.8e-67 227.3 0.2 1.1 1 0 0 1 1 1 1 SPX domain zf-C3HC4 PF00097.25 EXF80084.1 - 7.8e-08 32.1 11.3 1.6e-07 31.1 11.3 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EXF80084.1 - 2.3e-07 30.9 9.4 4.4e-07 29.9 9.4 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.6 EXF80084.1 - 4.2e-07 29.7 9.2 7.8e-07 28.9 9.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EXF80084.1 - 6.1e-07 29.2 9.9 6.1e-07 29.2 9.9 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EXF80084.1 - 1.6e-05 25.1 11.8 1.6e-05 25.1 11.8 2.2 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.6 EXF80084.1 - 5.6e-05 23.0 10.1 0.00015 21.6 10.1 1.8 1 1 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EXF80084.1 - 6.4e-05 22.9 8.0 0.0002 21.3 8.0 1.9 1 0 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.6 EXF80084.1 - 0.013 15.4 10.6 0.07 13.0 11.0 2.0 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_6 PF14835.6 EXF80084.1 - 0.042 13.7 2.8 0.1 12.5 2.8 1.6 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-RING_10 PF16685.5 EXF80084.1 - 0.045 13.9 4.5 0.11 12.6 4.5 1.7 1 0 0 1 1 1 0 zinc RING finger of MSL2 FoP_duplication PF13865.6 EXF80084.1 - 0.14 12.7 0.1 0.27 11.8 0.1 1.4 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 TerY_C PF15616.6 EXF80084.1 - 0.19 11.8 2.0 0.39 10.8 2.0 1.5 1 0 0 1 1 1 0 TerY-C metal binding domain zf-rbx1 PF12678.7 EXF80084.1 - 0.22 11.8 13.3 0.18 12.1 9.5 2.5 2 1 0 2 2 2 0 RING-H2 zinc finger domain zf-RING_4 PF14570.6 EXF80084.1 - 0.25 11.1 9.8 0.031 14.1 5.2 1.8 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-ANAPC11 PF12861.7 EXF80084.1 - 0.41 10.7 5.8 0.18 11.9 2.8 1.9 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger DnaJ PF00226.31 EXF80085.1 - 2.6e-24 85.1 0.4 2.6e-24 85.1 0.4 2.2 2 0 0 2 2 2 1 DnaJ domain zf-C2H2_jaz PF12171.8 EXF80085.1 - 1.6e-10 40.9 2.4 3.9e-10 39.7 2.4 1.7 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EXF80085.1 - 2.1e-09 37.4 1.9 4.9e-09 36.3 1.9 1.7 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 EXF80085.1 - 0.00043 20.6 1.7 0.00099 19.4 1.7 1.5 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.26 EXF80085.1 - 0.0097 16.3 0.6 0.022 15.2 0.6 1.7 1 0 0 1 1 1 1 Zinc finger, C2H2 type Actin_micro PF17003.5 EXF80085.1 - 0.016 14.4 0.2 0.023 13.9 0.2 1.2 1 0 0 1 1 1 0 Putative actin-like family zf-C2H2_4 PF13894.6 EXF80085.1 - 0.019 15.8 0.3 0.054 14.4 0.3 1.8 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EXF80085.1 - 0.024 14.6 1.3 0.044 13.8 1.3 1.4 1 0 0 1 1 1 0 C2H2-type zinc finger RPT PF13446.6 EXF80085.1 - 0.071 13.0 0.0 0.33 10.9 0.0 2.2 1 1 1 2 2 2 0 A repeated domain in UCH-protein MIT PF04212.18 EXF80085.1 - 0.096 12.8 2.4 0.17 12.0 0.1 2.8 3 1 0 3 3 3 0 MIT (microtubule interacting and transport) domain Peptidase_C54 PF03416.19 EXF80086.1 - 1.1e-93 313.6 0.0 1.8e-93 313.0 0.0 1.3 1 0 0 1 1 1 1 Peptidase family C54 R3H PF01424.22 EXF80087.1 - 1.5e-15 56.9 0.0 3e-15 55.9 0.0 1.5 1 0 0 1 1 1 1 R3H domain G-patch PF01585.23 EXF80087.1 - 2.7e-10 40.0 1.6 7.6e-10 38.5 1.6 1.9 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 EXF80087.1 - 0.0012 18.8 0.5 0.0046 17.0 0.5 2.0 1 0 0 1 1 1 1 G-patch domain Histone PF00125.24 EXF80088.1 - 9.1e-22 77.8 2.0 1.1e-21 77.5 2.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EXF80088.1 - 2e-05 24.8 0.0 4.7e-05 23.6 0.0 1.6 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 EXF80088.1 - 0.00033 21.1 0.0 0.00056 20.4 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A RP-C PF03428.13 EXF80088.1 - 0.045 13.4 0.1 0.11 12.1 0.1 1.6 1 1 0 1 1 1 0 Replication protein C N-terminal domain SH3_1 PF00018.28 EXF80089.1 - 5.7e-27 93.1 0.0 2.9e-13 49.2 0.0 2.7 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.6 EXF80089.1 - 1.5e-18 66.4 0.1 3.3e-09 36.5 0.1 2.9 2 0 0 2 2 2 2 Variant SH3 domain PX PF00787.24 EXF80089.1 - 5.1e-13 49.0 0.0 9.4e-13 48.1 0.0 1.4 1 0 0 1 1 1 1 PX domain SH3_2 PF07653.17 EXF80089.1 - 1.7e-12 46.8 0.0 1.5e-07 31.0 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain PB1 PF00564.24 EXF80089.1 - 4e-08 33.1 0.1 6.5e-08 32.4 0.1 1.3 1 0 0 1 1 1 1 PB1 domain Rad60-SLD PF11976.8 EXF80089.1 - 0.19 11.6 0.2 1.4 8.8 0.2 2.3 1 1 1 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like Pex14_N PF04695.13 EXF80089.1 - 1.1 9.9 18.5 6.2 7.5 1.0 3.3 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region SAC3_GANP PF03399.16 EXF80090.1 - 7e-24 84.7 1.6 7.7e-22 78.0 1.6 2.1 1 1 0 1 1 1 1 SAC3/GANP family CSN8_PSD8_EIF3K PF10075.9 EXF80090.1 - 0.038 14.0 0.0 0.082 12.9 0.0 1.5 1 0 0 1 1 1 0 CSN8/PSMD8/EIF3K family EAP30 PF04157.16 EXF80091.1 - 1.9e-42 145.2 0.1 2.5e-42 144.8 0.1 1.2 1 0 0 1 1 1 1 EAP30/Vps36 family Vps36-NZF-N PF16988.5 EXF80091.1 - 1.7e-22 78.6 11.0 3.4e-22 77.6 2.5 2.9 2 1 0 2 2 2 2 Vacuolar protein sorting 36 NZF-N zinc-finger domain Vps36_ESCRT-II PF11605.8 EXF80091.1 - 3e-14 53.0 0.0 5.3e-14 52.2 0.0 1.4 1 0 0 1 1 1 1 Vacuolar protein sorting protein 36 Vps36 zf-Sec23_Sec24 PF04810.15 EXF80091.1 - 0.00022 21.2 3.0 0.023 14.7 0.2 2.5 2 0 0 2 2 2 2 Sec23/Sec24 zinc finger zf-RanBP PF00641.18 EXF80091.1 - 0.00077 18.7 1.9 0.00077 18.7 1.9 2.6 3 0 0 3 3 3 2 Zn-finger in Ran binding protein and others GRAM PF02893.20 EXF80091.1 - 0.0049 16.7 0.0 0.0089 15.9 0.0 1.3 1 0 0 1 1 1 1 GRAM domain DZR PF12773.7 EXF80091.1 - 1.3 9.1 7.7 0.083 12.9 1.1 2.2 2 1 0 2 2 2 0 Double zinc ribbon Peptidase_S9 PF00326.21 EXF80093.1 - 1.4e-44 152.1 0.0 2.3e-44 151.4 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family AXE1 PF05448.12 EXF80093.1 - 9.8e-05 21.2 0.1 0.031 13.0 0.1 2.6 2 1 0 2 2 2 1 Acetyl xylan esterase (AXE1) PD40 PF07676.12 EXF80093.1 - 0.00022 21.1 0.4 0.16 12.0 0.0 3.1 3 0 0 3 3 3 2 WD40-like Beta Propeller Repeat Abhydrolase_1 PF00561.20 EXF80093.1 - 0.0021 17.7 0.6 0.25 11.0 0.7 2.4 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_3 PF07859.13 EXF80093.1 - 0.0047 16.8 0.0 0.78 9.6 0.0 2.4 2 0 0 2 2 2 2 alpha/beta hydrolase fold Mannosidase_ig PF17786.1 EXF80094.1 - 3.2e-19 69.3 0.2 8.4e-19 68.0 0.2 1.8 1 0 0 1 1 1 1 Mannosidase Ig/CBM-like domain Glyco_hydro_2 PF00703.21 EXF80094.1 - 4.2e-09 37.0 0.0 1.3e-08 35.4 0.0 1.9 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 Ig_mannosidase PF17753.1 EXF80094.1 - 0.0028 17.3 0.1 0.014 15.1 0.0 2.2 2 0 0 2 2 2 1 Ig-fold domain Glyco_hydro_2_C PF02836.17 EXF80094.1 - 0.0096 15.1 0.0 0.017 14.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain PI31_Prot_N PF11566.8 EXF80095.1 - 2.3e-57 193.3 0.0 3e-57 193.0 0.0 1.1 1 0 0 1 1 1 1 PI31 proteasome regulator N-terminal PI31_Prot_C PF08577.11 EXF80095.1 - 9.3e-19 68.4 20.2 9.3e-19 68.4 20.2 2.8 3 1 1 4 4 4 1 PI31 proteasome regulator HORMA PF02301.18 EXF80096.1 - 6.7e-11 42.2 0.0 8.8e-11 41.8 0.0 1.1 1 0 0 1 1 1 1 HORMA domain DUF3455 PF11937.8 EXF80096.1 - 0.073 13.5 0.0 0.099 13.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3455) MFS_1 PF07690.16 EXF80097.1 - 1.6e-31 109.5 20.0 1.6e-31 109.5 20.0 2.5 1 1 2 3 3 3 1 Major Facilitator Superfamily Phage_holin_5_1 PF06946.11 EXF80097.1 - 0.2 12.0 2.7 6.9 7.1 0.1 2.8 2 0 0 2 2 2 0 Bacteriophage A118-like holin, Hol118 DUF4231 PF14015.6 EXF80097.1 - 0.98 9.9 6.5 0.28 11.6 0.5 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF4231) GIY-YIG PF01541.24 EXF80098.1 - 0.012 15.8 0.0 0.032 14.5 0.0 1.7 1 0 0 1 1 1 0 GIY-YIG catalytic domain Sin_N PF04801.13 EXF80100.1 - 5.9e-24 85.1 0.0 1.7e-23 83.6 0.0 1.7 1 1 0 1 1 1 1 Sin-like protein conserved region PAT1 PF09770.9 EXF80101.1 - 0 1361.3 3.3 0 1361.1 3.3 1.0 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 T3SS_needle_F PF09392.10 EXF80101.1 - 2.6 8.3 4.9 0.31 11.3 0.2 2.0 2 0 0 2 2 2 0 Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF Glyco_transf_15 PF01793.16 EXF80102.1 - 2.3e-140 467.5 6.6 2.8e-140 467.2 6.6 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase Ribosomal_L32e PF01655.18 EXF80102.1 - 0.037 14.4 0.2 0.38 11.2 0.1 2.2 2 0 0 2 2 2 0 Ribosomal protein L32 Ribosom_S12_S23 PF00164.25 EXF80103.1 - 3.1e-29 100.9 0.6 4.2e-29 100.5 0.6 1.2 1 0 0 1 1 1 1 Ribosomal protein S12/S23 Acyl-CoA_dh_1 PF00441.24 EXF80104.1 - 5e-40 137.2 4.0 8.1e-40 136.5 4.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 EXF80104.1 - 2.4e-29 102.3 0.3 5.4e-29 101.1 0.0 1.8 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 EXF80104.1 - 6.1e-24 84.0 0.0 1.2e-23 83.1 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 EXF80104.1 - 5.4e-18 65.6 0.5 1e-17 64.6 0.5 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain HpaB_N PF11794.8 EXF80104.1 - 0.00088 19.0 0.0 0.0023 17.7 0.0 1.6 1 1 0 1 1 1 1 4-hydroxyphenylacetate 3-hydroxylase N terminal AgrD PF05931.11 EXF80104.1 - 0.025 14.6 0.2 0.07 13.2 0.0 1.8 2 0 0 2 2 2 0 Staphylococcal AgrD protein HR1 PF02185.16 EXF80105.1 - 2.3e-22 78.9 19.9 3.1e-12 46.4 4.5 3.1 2 0 0 2 2 2 2 Hr1 repeat C1_1 PF00130.22 EXF80105.1 - 3.8e-20 71.5 31.5 2.6e-12 46.4 11.4 2.2 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) C2 PF00168.30 EXF80105.1 - 9e-05 22.7 0.0 0.00017 21.8 0.0 1.4 1 0 0 1 1 1 1 C2 domain Pkinase_C PF00433.24 EXF80105.1 - 0.017 15.8 0.1 0.066 13.9 0.1 2.1 1 0 0 1 1 1 0 Protein kinase C terminal domain Glyoxalase_6 PF18029.1 EXF80105.1 - 0.083 13.7 0.1 2.6 8.9 0.0 2.5 2 0 0 2 2 2 0 Glyoxalase-like domain zf-RING_9 PF13901.6 EXF80105.1 - 0.74 9.7 22.4 1.1 9.2 7.3 2.4 2 0 0 2 2 2 0 Putative zinc-RING and/or ribbon She9_MDM33 PF05546.11 EXF80106.1 - 1.8e-81 272.7 6.9 2.8e-81 272.1 6.9 1.3 1 0 0 1 1 1 1 She9 / Mdm33 family Citrate_synt PF00285.21 EXF80106.1 - 0.0038 16.4 0.4 0.0038 16.4 0.4 2.2 2 0 0 2 2 2 1 Citrate synthase, C-terminal domain Macoilin PF09726.9 EXF80106.1 - 0.05 12.2 7.0 0.13 10.8 7.0 1.6 1 0 0 1 1 1 0 Macoilin family DUF3847 PF12958.7 EXF80106.1 - 0.056 13.6 1.0 15 5.8 0.2 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3847) SOG2 PF10428.9 EXF80106.1 - 0.077 12.2 30.1 0.0087 15.3 25.1 1.8 2 0 0 2 2 2 0 RAM signalling pathway protein BST2 PF16716.5 EXF80106.1 - 3.6 8.3 10.5 0.86 10.2 5.7 2.5 2 0 0 2 2 2 0 Bone marrow stromal antigen 2 NAM-associated PF14303.6 EXF80106.1 - 6.5 7.4 16.0 0.63 10.7 6.8 3.3 2 1 1 3 3 3 0 No apical meristem-associated C-terminal domain DUF2235 PF09994.9 EXF80107.1 - 1.6e-83 280.4 0.0 2e-83 280.1 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) SBP_bac_6 PF13343.6 EXF80108.1 - 2e-15 56.9 0.0 3e-15 56.3 0.0 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_8 PF13416.6 EXF80108.1 - 1.6e-07 31.5 0.0 4.5e-07 30.0 0.0 1.7 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_11 PF13531.6 EXF80108.1 - 1.2e-05 25.2 0.1 1.8e-05 24.6 0.1 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 EXF80108.1 - 0.0077 16.2 0.3 0.015 15.2 0.3 1.8 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein GST_N_3 PF13417.6 EXF80110.1 - 0.0067 16.8 0.0 0.013 15.9 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EXF80110.1 - 0.018 15.3 0.0 0.028 14.7 0.0 1.3 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain Ank_2 PF12796.7 EXF80111.1 - 1.3e-07 32.1 0.0 3.2e-07 30.8 0.0 1.6 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EXF80111.1 - 2.2e-05 24.9 0.1 0.0012 19.4 0.0 2.3 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 EXF80111.1 - 0.00014 22.1 0.6 1.5 9.4 0.0 3.7 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.6 EXF80111.1 - 0.00017 21.8 0.2 2.5 9.0 0.0 3.7 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 EXF80111.1 - 0.068 13.5 0.1 6.5 7.2 0.0 2.8 2 1 1 3 3 3 0 Ankyrin repeats (many copies) Sulfatase PF00884.23 EXF80113.1 - 3e-74 250.2 0.0 3.5e-74 250.0 0.0 1.1 1 0 0 1 1 1 1 Sulfatase DUF229 PF02995.17 EXF80113.1 - 0.0019 16.9 0.0 0.0026 16.4 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF229) DUF4976 PF16347.5 EXF80113.1 - 0.0037 17.5 0.0 0.014 15.6 0.0 2.0 2 1 0 2 2 2 1 Domain of unknown function (DUF4976) Phosphodiest PF01663.22 EXF80113.1 - 0.032 13.8 0.0 3 7.4 0.0 2.2 2 0 0 2 2 2 0 Type I phosphodiesterase / nucleotide pyrophosphatase RNA_pol_Rpb1_4 PF05000.17 EXF80113.1 - 0.032 14.1 0.1 0.074 13.0 0.1 1.6 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 4 Sugar_tr PF00083.24 EXF80114.1 - 7.6e-60 203.1 10.1 9.3e-60 202.8 10.1 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF80114.1 - 1.8e-11 43.6 15.5 1.8e-11 43.6 15.5 1.7 2 0 0 2 2 2 1 Major Facilitator Superfamily Pox_A14 PF05767.12 EXF80114.1 - 0.073 13.2 0.9 0.2 11.8 0.2 2.1 2 0 0 2 2 2 0 Poxvirus virion envelope protein A14 Trep_Strep PF09605.10 EXF80114.1 - 4.4 7.3 10.0 0.37 10.8 3.6 2.4 2 0 0 2 2 2 0 Hypothetical bacterial integral membrane protein (Trep_Strep) Sugar_tr PF00083.24 EXF80119.1 - 1e-65 222.4 13.4 5.4e-64 216.7 13.4 2.0 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF80119.1 - 2.7e-19 69.3 22.8 2.7e-15 56.2 8.9 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EXF80119.1 - 1.1e-06 27.4 1.0 1.8e-06 26.7 1.0 1.4 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) p450 PF00067.22 EXF80120.1 - 1.2e-55 189.1 0.0 6.1e-50 170.3 0.0 2.0 2 0 0 2 2 2 2 Cytochrome P450 C166 PF17615.2 EXF80122.1 - 2.6e-21 76.4 2.5 2.6e-21 76.4 2.5 2.1 1 1 1 2 2 2 2 Family of unknown function GMC_oxred_N PF00732.19 EXF80123.1 - 1.1e-29 103.8 0.0 2.2e-26 92.9 0.0 3.0 1 1 1 2 2 2 2 GMC oxidoreductase GMC_oxred_C PF05199.13 EXF80123.1 - 2.1e-29 102.9 0.0 3.4e-29 102.2 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase Pyr_redox_2 PF07992.14 EXF80123.1 - 8.8e-05 21.9 0.0 0.00014 21.2 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EXF80123.1 - 0.00014 22.0 0.0 0.00046 20.4 0.0 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EXF80123.1 - 0.0007 18.8 0.1 0.0019 17.4 0.2 1.6 2 0 0 2 2 2 1 FAD binding domain FAD_oxidored PF12831.7 EXF80123.1 - 0.002 17.6 0.0 0.0033 16.8 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 EXF80123.1 - 0.0079 14.9 0.0 0.012 14.4 0.0 1.2 1 0 0 1 1 1 1 HI0933-like protein Lycopene_cycl PF05834.12 EXF80123.1 - 0.023 13.7 0.2 0.067 12.2 0.2 1.6 2 0 0 2 2 2 0 Lycopene cyclase protein FAD_binding_3 PF01494.19 EXF80123.1 - 0.042 13.1 0.4 0.065 12.5 0.4 1.2 1 0 0 1 1 1 0 FAD binding domain Pyr_redox PF00070.27 EXF80123.1 - 0.11 13.1 0.1 0.3 11.7 0.1 1.8 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EXF80123.1 - 0.17 11.1 0.3 12 5.1 0.4 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase COesterase PF00135.28 EXF80124.1 - 3.6e-92 309.9 0.0 9e-92 308.6 0.0 1.5 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EXF80124.1 - 5.3e-09 36.2 0.1 5.3e-08 33.0 0.1 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EXF80124.1 - 0.014 14.9 0.0 0.024 14.1 0.0 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family peroxidase PF00141.23 EXF80125.1 - 1.3e-22 80.7 0.7 2e-22 80.0 0.7 1.3 1 0 0 1 1 1 1 Peroxidase DUF5337 PF17272.2 EXF80125.1 - 0.057 13.3 0.4 0.12 12.3 0.4 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5337) PSI_PSAK PF01241.18 EXF80125.1 - 0.061 13.3 0.3 0.21 11.6 0.0 2.1 2 0 0 2 2 2 0 Photosystem I psaG / psaK End_beta_barrel PF12195.8 EXF80125.1 - 2.3 8.2 5.4 0.58 10.1 0.4 2.6 3 0 0 3 3 3 0 Beta barrel domain of bacteriophage endosialidase GMC_oxred_C PF05199.13 EXF80126.1 - 5.4e-12 46.5 0.0 1.2e-11 45.4 0.0 1.6 1 0 0 1 1 1 1 GMC oxidoreductase Ribonuclease_T2 PF00445.18 EXF80127.1 - 3.7e-14 53.4 0.0 1e-13 52.0 0.0 1.7 1 0 0 1 1 1 1 Ribonuclease T2 family FAD_binding_4 PF01565.23 EXF80127.1 - 7.6e-14 51.6 0.0 1.5e-13 50.7 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EXF80127.1 - 4.7e-07 29.8 0.0 1.1e-06 28.6 0.0 1.6 1 0 0 1 1 1 1 Berberine and berberine like Anti-TRAP PF15777.5 EXF80127.1 - 0.024 14.6 0.0 0.088 12.8 0.0 2.0 1 0 0 1 1 1 0 Tryptophan RNA-binding attenuator protein inhibitory protein IF-2B PF01008.17 EXF80128.1 - 2.8e-43 148.2 0.0 3.8e-43 147.7 0.0 1.2 1 0 0 1 1 1 1 Initiation factor 2 subunit family DeoRC PF00455.22 EXF80128.1 - 0.05 13.5 0.0 0.87 9.5 0.0 2.2 2 0 0 2 2 2 0 DeoR C terminal sensor domain DUF1681 PF07933.14 EXF80129.1 - 2.7e-58 195.9 0.0 4.5e-58 195.2 0.0 1.3 2 0 0 2 2 2 1 Protein of unknown function (DUF1681) CRA_rpt PF07046.11 EXF80129.1 - 0.097 12.8 5.2 0.25 11.6 5.2 1.6 1 0 0 1 1 1 0 Cytoplasmic repetitive antigen (CRA) like repeat Fer4_12 PF13353.6 EXF80131.1 - 3.4e-05 24.1 0.2 7.2e-05 23.1 0.2 1.5 1 0 0 1 1 1 1 4Fe-4S single cluster domain Radical_SAM PF04055.21 EXF80131.1 - 3.8e-05 24.1 0.0 6.3e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_14 PF13394.6 EXF80131.1 - 0.0035 17.5 0.0 0.0087 16.2 0.0 1.7 1 0 0 1 1 1 1 4Fe-4S single cluster domain Glycos_trans_3N PF02885.17 EXF80131.1 - 0.14 12.0 0.0 0.68 9.8 0.0 2.2 3 0 0 3 3 3 0 Glycosyl transferase family, helical bundle domain GMC_oxred_N PF00732.19 EXF80132.1 - 2.3e-66 224.2 0.0 4.2e-66 223.3 0.0 1.4 1 1 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EXF80132.1 - 2.4e-28 99.5 0.0 4.4e-28 98.6 0.0 1.5 1 0 0 1 1 1 1 GMC oxidoreductase DAO PF01266.24 EXF80132.1 - 5.6e-05 22.9 0.1 0.00019 21.2 0.0 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EXF80132.1 - 0.00014 22.1 0.0 0.00038 20.6 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EXF80132.1 - 0.0039 16.3 0.0 0.013 14.7 0.0 1.8 2 0 0 2 2 2 1 FAD binding domain Thi4 PF01946.17 EXF80132.1 - 0.03 13.6 0.0 0.05 12.8 0.0 1.3 1 0 0 1 1 1 0 Thi4 family Pyr_redox_2 PF07992.14 EXF80132.1 - 0.036 13.3 0.1 0.23 10.7 0.1 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EXF80132.1 - 0.043 13.1 0.1 2.8 7.1 0.1 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EXF80132.1 - 0.05 12.6 0.0 0.075 12.1 0.0 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein NAD_binding_9 PF13454.6 EXF80132.1 - 0.11 12.5 0.1 0.21 11.6 0.1 1.4 1 0 0 1 1 1 0 FAD-NAD(P)-binding HI0933_like PF03486.14 EXF80132.1 - 0.13 11.0 0.1 0.35 9.5 0.0 1.7 2 0 0 2 2 2 0 HI0933-like protein AAA PF00004.29 EXF80133.1 - 3.9e-11 43.5 0.0 8.3e-11 42.4 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EXF80133.1 - 1.5e-06 28.5 0.0 4.3e-06 27.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 EXF80133.1 - 1.5e-05 25.0 0.0 2.9e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Rad17 PF03215.15 EXF80133.1 - 5.2e-05 23.3 0.0 0.00022 21.2 0.0 2.0 2 0 0 2 2 2 1 Rad17 P-loop domain RuvB_N PF05496.12 EXF80133.1 - 5.2e-05 23.0 0.0 0.0001 22.1 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 EXF80133.1 - 0.0016 18.6 0.1 0.0051 17.0 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EXF80133.1 - 0.0018 18.0 0.1 0.0042 16.8 0.1 1.5 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.6 EXF80133.1 - 0.0025 17.9 0.0 0.0047 17.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EXF80133.1 - 0.0029 18.0 0.4 0.0092 16.4 0.0 2.0 2 0 0 2 2 1 1 AAA ATPase domain AAA_18 PF13238.6 EXF80133.1 - 0.017 15.6 0.0 0.04 14.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 EXF80133.1 - 0.022 13.9 0.0 0.038 13.2 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain NTPase_1 PF03266.15 EXF80133.1 - 0.028 14.3 0.2 0.095 12.6 0.1 1.9 1 1 1 2 2 2 0 NTPase RsgA_GTPase PF03193.16 EXF80133.1 - 0.041 13.8 0.0 0.11 12.4 0.0 1.7 1 0 0 1 1 1 0 RsgA GTPase AAA_19 PF13245.6 EXF80133.1 - 0.069 13.5 0.5 0.34 11.3 0.5 2.1 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EXF80133.1 - 0.07 12.6 0.1 0.6 9.6 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region Mg_chelatase PF01078.21 EXF80133.1 - 0.085 12.2 0.0 1.5 8.1 0.0 2.2 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI KTI12 PF08433.10 EXF80133.1 - 0.1 12.1 0.1 0.2 11.1 0.1 1.5 1 0 0 1 1 1 0 Chromatin associated protein KTI12 ABC_tran PF00005.27 EXF80133.1 - 0.1 13.1 0.1 0.31 11.6 0.1 1.8 1 0 0 1 1 1 0 ABC transporter AAA_24 PF13479.6 EXF80133.1 - 0.1 12.3 0.0 0.21 11.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 EXF80133.1 - 0.11 12.5 0.0 0.22 11.5 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_2 PF07724.14 EXF80133.1 - 0.17 12.0 0.5 2.7 8.1 0.0 2.8 3 0 0 3 3 3 0 AAA domain (Cdc48 subfamily) HIT PF01230.23 EXF80134.1 - 5.8e-22 78.3 0.1 1e-21 77.5 0.1 1.3 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 EXF80134.1 - 6.4e-06 26.6 0.0 1.3e-05 25.7 0.0 1.5 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding Ferrochelatase PF00762.19 EXF80135.1 - 1.8e-97 326.2 0.0 2.2e-97 326.0 0.0 1.1 1 0 0 1 1 1 1 Ferrochelatase Cytomega_UL20A PF05984.12 EXF80135.1 - 0.13 12.6 0.1 0.29 11.5 0.1 1.5 1 0 0 1 1 1 0 Cytomegalovirus UL20A protein Ku PF02735.16 EXF80136.1 - 1.3e-44 152.3 0.0 3e-44 151.2 0.0 1.6 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_N PF03731.15 EXF80136.1 - 5e-32 111.4 0.0 7.5e-32 110.9 0.0 1.3 1 0 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain Ku_C PF03730.14 EXF80136.1 - 1.1e-28 99.7 2.9 1.1e-28 99.7 2.9 2.0 2 0 0 2 2 2 1 Ku70/Ku80 C-terminal arm SAP PF02037.27 EXF80136.1 - 6.7e-09 35.3 0.1 7.6e-08 31.9 0.1 2.3 2 0 0 2 2 2 1 SAP domain MFS_1 PF07690.16 EXF80139.1 - 1.9e-20 73.1 32.9 8e-16 57.9 14.8 2.9 2 1 0 3 3 3 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF80139.1 - 2.6e-05 23.3 8.2 3.2e-05 23.0 6.5 1.9 1 1 0 1 1 1 1 Sugar (and other) transporter Myb_Cef PF11831.8 EXF80140.1 - 6e-52 176.6 10.5 6e-52 176.6 10.5 3.0 3 1 1 4 4 4 1 pre-mRNA splicing factor component Myb_DNA-binding PF00249.31 EXF80140.1 - 3e-23 81.8 5.3 8.5e-11 41.9 0.9 2.7 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EXF80140.1 - 5e-22 77.9 6.8 6.3e-15 55.2 2.8 3.1 2 1 1 3 3 3 2 Myb-like DNA-binding domain Rap1_C PF11626.8 EXF80140.1 - 0.22 11.6 0.1 0.22 11.6 0.1 3.4 4 0 0 4 4 4 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain MFS_1 PF07690.16 EXF80141.1 - 8.5e-41 140.0 52.2 8.5e-41 140.0 52.2 2.5 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF80141.1 - 4.1e-12 45.7 12.6 4.1e-12 45.7 12.6 2.9 2 1 1 3 3 3 1 Sugar (and other) transporter TRI12 PF06609.13 EXF80141.1 - 4.4e-09 35.3 16.0 6.9e-09 34.7 16.0 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) OATP PF03137.20 EXF80141.1 - 0.0033 15.8 1.1 0.0033 15.8 1.1 1.9 2 0 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family F-box-like PF12937.7 EXF80142.1 - 0.048 13.6 0.1 0.42 10.6 0.1 2.5 1 1 0 1 1 1 0 F-box-like Mito_carr PF00153.27 EXF80143.1 - 3.9e-17 62.0 0.0 4.3e-10 39.4 0.0 3.4 3 1 0 3 3 3 2 Mitochondrial carrier protein Lactamase_B PF00753.27 EXF80144.1 - 1.9e-07 31.3 0.1 3.8e-07 30.3 0.1 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EXF80144.1 - 0.13 11.7 0.0 0.23 10.9 0.0 1.5 1 0 0 1 1 1 0 Beta-lactamase superfamily domain Abhydrolase_4 PF08386.10 EXF80145.1 - 1.3e-21 76.6 0.0 4.3e-21 75.0 0.0 1.8 2 0 0 2 2 2 1 TAP-like protein Abhydrolase_1 PF00561.20 EXF80145.1 - 7.4e-20 71.7 0.0 1e-18 68.0 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold FSH1 PF03959.13 EXF80145.1 - 0.028 14.1 0.0 0.055 13.1 0.0 1.4 1 0 0 1 1 1 0 Serine hydrolase (FSH1) T5orf172 PF10544.9 EXF80146.1 - 1.4e-14 54.5 0.2 3e-14 53.4 0.2 1.5 1 0 0 1 1 1 1 T5orf172 domain MUG113 PF13455.6 EXF80146.1 - 5.6e-06 26.9 0.1 1.1e-05 26.0 0.1 1.5 1 0 0 1 1 1 1 Meiotically up-regulated gene 113 FMO-like PF00743.19 EXF80147.1 - 7e-29 100.6 0.0 1.2e-17 63.6 0.0 3.0 3 0 0 3 3 3 3 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EXF80147.1 - 2.9e-09 36.6 0.4 4.5e-06 26.1 0.0 3.1 2 1 1 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EXF80147.1 - 2.5e-06 27.6 0.1 7.3e-06 26.1 0.0 1.8 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EXF80147.1 - 2.4e-05 23.7 0.0 0.0062 15.8 0.0 2.9 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EXF80147.1 - 0.00064 19.4 1.0 0.031 13.9 0.4 2.3 2 0 0 2 2 2 1 FAD dependent oxidoreductase K_oxygenase PF13434.6 EXF80147.1 - 0.00085 18.6 0.1 0.17 11.0 0.0 3.1 3 1 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 EXF80147.1 - 0.001 19.1 0.1 0.0059 16.6 0.1 2.3 1 1 0 1 1 1 1 FAD-NAD(P)-binding HI0933_like PF03486.14 EXF80147.1 - 0.043 12.5 0.3 0.064 12.0 0.3 1.2 1 0 0 1 1 1 0 HI0933-like protein Glu_dehyd_C PF16912.5 EXF80147.1 - 0.085 12.3 0.0 0.16 11.4 0.0 1.4 1 0 0 1 1 1 0 Glucose dehydrogenase C-terminus Semialdhyde_dh PF01118.24 EXF80147.1 - 0.14 12.6 0.0 0.45 11.0 0.0 1.8 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain OCD_Mu_crystall PF02423.15 EXF80147.1 - 0.16 10.9 0.2 0.27 10.1 0.2 1.3 1 0 0 1 1 1 0 Ornithine cyclodeaminase/mu-crystallin family CMD PF02627.20 EXF80148.1 - 5.6e-18 64.8 0.1 9.2e-18 64.1 0.1 1.4 1 0 0 1 1 1 1 Carboxymuconolactone decarboxylase family TraC PF07820.12 EXF80148.1 - 0.14 12.5 0.2 1.6 9.1 0.1 2.3 2 0 0 2 2 2 0 TraC-like protein PAF-AH_p_II PF03403.13 EXF80150.1 - 4.9e-14 51.6 0.0 8.6e-07 27.8 0.0 2.4 1 1 0 2 2 2 2 Platelet-activating factor acetylhydrolase, isoform II Chlorophyllase2 PF12740.7 EXF80150.1 - 6e-08 31.9 0.0 1.9e-07 30.3 0.0 1.7 2 0 0 2 2 2 1 Chlorophyllase enzyme Hydrolase_4 PF12146.8 EXF80150.1 - 5.5e-06 25.8 0.1 8.7e-05 21.9 0.1 2.1 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EXF80150.1 - 1e-05 26.2 1.3 1.7e-05 25.5 1.3 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.16 EXF80150.1 - 0.00045 20.1 0.0 0.0007 19.5 0.0 1.3 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Chlorophyllase PF07224.11 EXF80150.1 - 0.0019 17.3 0.0 0.0076 15.3 0.0 1.9 1 1 0 1 1 1 1 Chlorophyllase Abhydrolase_5 PF12695.7 EXF80150.1 - 0.015 15.1 0.1 1.9 8.2 0.0 2.2 2 0 0 2 2 2 0 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EXF80150.1 - 0.033 13.8 0.6 0.26 10.9 0.6 2.1 1 1 0 1 1 1 0 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EXF80150.1 - 0.051 13.0 0.0 0.091 12.2 0.0 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family NAD_binding_2 PF03446.15 EXF80151.1 - 4.7e-13 49.6 0.2 8.8e-13 48.7 0.0 1.5 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 EXF80151.1 - 4.2e-07 30.5 0.0 1e-06 29.2 0.0 1.7 1 1 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.19 EXF80151.1 - 1.1e-06 28.2 0.0 3.9e-06 26.4 0.0 1.8 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_Gly3P_dh_N PF01210.23 EXF80151.1 - 0.005 16.8 1.5 0.28 11.1 1.5 2.3 1 1 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Shikimate_DH PF01488.20 EXF80151.1 - 0.0069 16.4 0.0 0.012 15.7 0.0 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NmrA PF05368.13 EXF80151.1 - 0.013 15.1 0.0 0.019 14.5 0.0 1.3 1 0 0 1 1 1 0 NmrA-like family zf-C2H2 PF00096.26 EXF80152.1 - 0.0042 17.5 1.9 0.0042 17.5 1.9 3.9 4 0 0 4 4 4 2 Zinc finger, C2H2 type Acyltransf_C PF16076.5 EXF80152.1 - 0.071 13.2 0.3 0.16 12.1 0.3 1.5 1 0 0 1 1 1 0 Acyltransferase C-terminus zf-C2H2_jaz PF12171.8 EXF80152.1 - 0.14 12.5 3.3 4.7 7.6 0.2 3.4 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding SnoaL PF07366.12 EXF80153.1 - 6.4e-05 22.8 0.1 8.2e-05 22.4 0.1 1.2 1 0 0 1 1 1 1 SnoaL-like polyketide cyclase SnoaL_2 PF12680.7 EXF80153.1 - 0.0025 18.5 0.2 0.0035 18.0 0.2 1.3 1 1 0 1 1 1 1 SnoaL-like domain Rib_5-P_isom_A PF06026.14 EXF80154.1 - 1.1e-44 152.0 0.0 2e-44 151.2 0.0 1.3 1 0 0 1 1 1 1 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) DeoRC PF00455.22 EXF80154.1 - 0.017 15.0 0.0 5.5 6.9 0.0 2.2 2 0 0 2 2 2 0 DeoR C terminal sensor domain FAD_binding_4 PF01565.23 EXF80155.1 - 1.5e-18 66.8 3.0 3.5e-18 65.7 1.8 2.1 2 0 0 2 2 2 1 FAD binding domain ATP-synt_J PF04911.12 EXF80156.1 - 0.1 12.2 2.4 1.4 8.5 0.0 3.1 3 0 0 3 3 3 0 ATP synthase j chain MFS_1 PF07690.16 EXF80157.1 - 2.3e-37 128.7 48.7 2.3e-37 128.7 48.7 2.0 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EXF80157.1 - 6.3e-15 54.6 26.6 1.5e-14 53.4 26.4 1.4 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) WD40 PF00400.32 EXF80158.1 - 4.1e-11 43.3 5.2 0.018 15.9 0.0 5.3 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EXF80158.1 - 0.00083 19.6 0.9 1.9 8.9 0.0 4.4 4 1 0 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Adhesin_P1 PF03257.13 EXF80158.1 - 0.06 13.9 0.1 0.14 12.7 0.1 1.6 1 0 0 1 1 1 0 Mycoplasma adhesin P1 HpcH_HpaI PF03328.14 EXF80159.1 - 4.8e-22 78.2 0.0 8.9e-22 77.3 0.0 1.4 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family PK PF00224.21 EXF80159.1 - 0.15 10.9 0.0 0.24 10.2 0.0 1.2 1 0 0 1 1 1 0 Pyruvate kinase, barrel domain NMD3 PF04981.13 EXF80160.1 - 5.2e-78 261.9 4.1 7e-78 261.4 4.1 1.2 1 0 0 1 1 1 1 NMD3 family DUF35_N PF12172.8 EXF80160.1 - 0.083 12.8 5.7 0.95 9.4 0.0 2.8 3 0 0 3 3 3 0 Rubredoxin-like zinc ribbon domain (DUF35_N) RRM_1 PF00076.22 EXF80161.1 - 5.3e-08 32.6 0.0 7.1e-06 25.7 0.0 2.5 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nop14 PF04147.12 EXF80161.1 - 0.0019 16.5 15.6 0.0019 16.5 15.6 1.9 2 0 0 2 2 2 1 Nop14-like family eIF-3c_N PF05470.12 EXF80161.1 - 0.016 13.6 0.7 0.029 12.7 0.4 1.5 1 1 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus PTRF_SDPR PF15237.6 EXF80161.1 - 0.24 11.0 7.6 0.018 14.7 2.4 1.8 2 0 0 2 2 2 0 PTRF/SDPR family Aldedh PF00171.22 EXF80162.1 - 2e-131 438.7 0.0 2.5e-131 438.4 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 EXF80162.1 - 0.00026 20.1 0.1 0.00084 18.5 0.1 1.8 1 1 0 1 1 1 1 Acyl-CoA reductase (LuxC) DUF1487 PF07368.11 EXF80162.1 - 0.091 12.2 0.0 7.7 5.9 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1487) WD40 PF00400.32 EXF80163.1 - 7.1e-05 23.5 9.1 4.1 8.4 0.3 5.2 5 0 0 5 5 5 3 WD domain, G-beta repeat AMP-binding PF00501.28 EXF80164.1 - 2.2e-86 290.1 0.0 2.7e-86 289.8 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme MARVEL PF01284.23 EXF80165.1 - 3.3e-18 66.1 14.7 4.1e-18 65.8 14.7 1.1 1 0 0 1 1 1 1 Membrane-associating domain Cys_Met_Meta_PP PF01053.20 EXF80166.1 - 1.6e-150 500.9 0.0 1.8e-150 500.7 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 EXF80166.1 - 1e-12 48.1 0.3 1.8e-12 47.3 0.3 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_1_2 PF00155.21 EXF80166.1 - 1.5e-10 40.8 0.0 2.4e-10 40.1 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 EXF80166.1 - 2.3e-08 33.4 0.3 4.2e-08 32.5 0.3 1.4 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 EXF80166.1 - 4e-07 29.6 0.0 8e-07 28.6 0.0 1.4 1 0 0 1 1 1 1 Beta-eliminating lyase Met_gamma_lyase PF06838.11 EXF80166.1 - 0.00015 20.4 0.1 0.00022 19.9 0.1 1.2 1 0 0 1 1 1 1 Methionine gamma-lyase SepSecS PF05889.13 EXF80166.1 - 0.015 14.0 0.0 0.022 13.5 0.0 1.1 1 0 0 1 1 1 0 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS CPSase_L_D2 PF02786.17 EXF80166.1 - 0.14 11.7 0.1 0.25 10.8 0.1 1.4 1 0 0 1 1 1 0 Carbamoyl-phosphate synthase L chain, ATP binding domain Asparaginase_C PF17763.1 EXF80166.1 - 0.16 12.2 0.0 0.39 11.0 0.0 1.6 1 0 0 1 1 1 0 Glutaminase/Asparaginase C-terminal domain GDC-P PF02347.16 EXF80166.1 - 0.18 10.6 0.0 0.25 10.1 0.0 1.1 1 0 0 1 1 1 0 Glycine cleavage system P-protein DUF2012 PF09430.10 EXF80167.1 - 2.5e-22 79.3 0.0 3.2e-22 78.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2012) FAP PF07174.11 EXF80167.1 - 0.29 10.5 2.7 0.37 10.2 2.7 1.1 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) HNH_2 PF13391.6 EXF80168.1 - 0.022 14.9 0.0 0.042 14.0 0.0 1.5 1 0 0 1 1 1 0 HNH endonuclease TRF PF08558.10 EXF80169.1 - 1.2e-26 93.8 1.1 1.2e-26 93.8 1.1 1.8 2 0 0 2 2 2 1 Telomere repeat binding factor (TRF) Myb_DNA-binding PF00249.31 EXF80169.1 - 2.1e-05 24.6 0.0 4.2e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain PSK_trans_fac PF07704.11 EXF80169.1 - 0.46 11.3 10.5 4.9 8.0 0.2 3.4 2 0 0 2 2 2 0 Rv0623-like transcription factor DUF2924 PF11149.8 EXF80169.1 - 7.7 6.9 9.1 2.1 8.8 3.7 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2924) Hydantoinase_B PF02538.14 EXF80170.1 - 3.4e-215 715.3 1.0 5e-215 714.8 1.0 1.2 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Hydantoinase_A PF01968.18 EXF80170.1 - 1.9e-104 349.0 0.1 4.2e-104 347.9 0.1 1.6 1 0 0 1 1 1 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.13 EXF80170.1 - 1.7e-58 197.3 0.2 9.8e-57 191.5 0.0 2.3 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase N-terminal region Proteasome_A_N PF10584.9 EXF80170.1 - 0.043 13.5 0.1 0.083 12.6 0.1 1.5 1 0 0 1 1 1 0 Proteasome subunit A N-terminal signature Aminotran_1_2 PF00155.21 EXF80171.1 - 3.5e-69 233.7 0.0 3.9e-69 233.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.7 EXF80171.1 - 0.024 13.4 0.0 0.038 12.8 0.0 1.3 1 0 0 1 1 1 0 Alanine-glyoxylate amino-transferase DHDPS PF00701.22 EXF80172.1 - 7.9e-48 162.6 0.0 9.6e-48 162.4 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family PEP_mutase PF13714.6 EXF80172.1 - 0.00028 20.4 0.0 0.00044 19.8 0.0 1.3 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase Peripla_BP_1 PF00532.21 EXF80172.1 - 0.14 11.6 0.1 0.22 10.9 0.1 1.4 1 1 0 1 1 1 0 Periplasmic binding proteins and sugar binding domain of LacI family PucR PF07905.11 EXF80172.1 - 0.14 12.5 0.0 0.49 10.7 0.0 1.9 1 1 0 1 1 1 0 Purine catabolism regulatory protein-like family Methyltransf_18 PF12847.7 EXF80172.1 - 0.14 12.1 0.0 0.2 11.6 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain His_Phos_2 PF00328.22 EXF80173.1 - 0.00017 21.1 0.0 0.00047 19.6 0.0 1.6 1 1 1 2 2 2 1 Histidine phosphatase superfamily (branch 2) Clostridium_P47 PF06597.11 EXF80173.1 - 0.036 12.8 0.2 0.053 12.2 0.2 1.1 1 0 0 1 1 1 0 Clostridium P-47 protein DASH_Dad1 PF08649.10 EXF80174.1 - 2.2e-26 91.8 3.2 2.7e-26 91.5 3.2 1.1 1 0 0 1 1 1 1 DASH complex subunit Dad1 DASH_Dad4 PF08650.10 EXF80174.1 - 0.0027 17.6 0.5 0.004 17.1 0.5 1.2 1 0 0 1 1 1 1 DASH complex subunit Dad4 DASH_Dad2 PF08654.10 EXF80174.1 - 0.039 14.4 1.5 0.045 14.2 1.5 1.2 1 0 0 1 1 1 0 DASH complex subunit Dad2 V_ATPase_I PF01496.19 EXF80174.1 - 0.32 8.9 4.3 0.32 8.9 4.3 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family YwqJ-deaminase PF14431.6 EXF80175.1 - 0.045 13.9 0.1 0.087 13.0 0.1 1.4 1 0 0 1 1 1 0 YwqJ-like deaminase Ras PF00071.22 EXF80176.1 - 7.2e-48 162.2 0.0 9.6e-48 161.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EXF80176.1 - 5.3e-20 71.8 0.0 1e-19 70.9 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EXF80176.1 - 5.9e-05 22.6 0.0 0.00011 21.7 0.0 1.6 1 1 0 1 1 1 1 ADP-ribosylation factor family AAA_7 PF12775.7 EXF80176.1 - 0.081 12.4 0.0 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region Skp1_POZ PF03931.15 EXF80177.1 - 7.7e-09 35.6 0.0 1e-08 35.2 0.0 1.2 1 0 0 1 1 1 1 Skp1 family, tetramerisation domain DBR1 PF05011.13 EXF80178.1 - 2.1e-46 157.8 6.0 5e-46 156.6 0.0 2.2 1 1 1 2 2 2 2 Lariat debranching enzyme, C-terminal domain Metallophos PF00149.28 EXF80178.1 - 5.9e-06 26.9 0.1 9.2e-06 26.3 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase LSM PF01423.22 EXF80179.1 - 5e-19 67.8 0.1 6.4e-19 67.4 0.1 1.1 1 0 0 1 1 1 1 LSM domain PRMT5_TIM PF17285.2 EXF80180.1 - 5.9e-71 238.7 0.0 8.3e-71 238.2 0.0 1.2 1 0 0 1 1 1 1 PRMT5 TIM barrel domain PRMT5 PF05185.16 EXF80180.1 - 1.9e-66 223.2 0.0 3.4e-66 222.4 0.0 1.4 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase PRMT5_C PF17286.2 EXF80180.1 - 1.2e-56 191.4 0.0 1.8e-56 190.8 0.0 1.3 1 0 0 1 1 1 1 PRMT5 oligomerisation domain Met_10 PF02475.16 EXF80180.1 - 0.068 12.9 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Met-10+ like-protein OB_NTP_bind PF07717.16 EXF80181.1 - 1.8e-23 82.7 0.1 1.5e-22 79.8 0.0 2.5 3 0 0 3 3 3 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.23 EXF80181.1 - 5.5e-18 65.2 0.0 1.7e-17 63.7 0.0 1.9 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 EXF80181.1 - 3.6e-11 43.4 0.0 1.8e-10 41.2 0.0 2.2 3 0 0 3 3 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 EXF80181.1 - 1.4e-08 34.7 0.1 2.6e-08 33.8 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EXF80181.1 - 4.3e-06 27.1 0.0 1.2e-05 25.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain SRP54 PF00448.22 EXF80181.1 - 7.7e-05 22.4 0.1 0.00029 20.5 0.1 1.8 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain T2SSE PF00437.20 EXF80181.1 - 0.00024 20.3 0.0 0.00045 19.4 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_30 PF13604.6 EXF80181.1 - 0.0031 17.3 0.0 0.0053 16.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain Flavi_DEAD PF07652.14 EXF80181.1 - 0.012 15.6 0.2 0.027 14.5 0.2 1.6 1 0 0 1 1 1 0 Flavivirus DEAD domain ResIII PF04851.15 EXF80181.1 - 0.02 14.9 0.0 3.4 7.6 0.0 2.4 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit DUF2075 PF09848.9 EXF80181.1 - 0.065 12.5 0.0 0.11 11.7 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) RsgA_GTPase PF03193.16 EXF80181.1 - 0.16 11.9 0.0 0.78 9.6 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase adh_short PF00106.25 EXF80182.1 - 1e-26 93.6 0.1 1.1e-25 90.2 0.1 1.9 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF80182.1 - 3.4e-19 69.3 0.5 5e-18 65.5 0.5 1.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF80182.1 - 6e-06 26.3 0.0 9e-06 25.7 0.0 1.2 1 0 0 1 1 1 1 KR domain 3HCDH_N PF02737.18 EXF80182.1 - 0.0035 17.3 0.3 0.005 16.7 0.3 1.2 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain F420_oxidored PF03807.17 EXF80182.1 - 0.12 12.9 0.2 0.19 12.3 0.2 1.3 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent FAD_binding_3 PF01494.19 EXF80183.1 - 7.3e-22 78.1 0.0 1.1e-21 77.5 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain ADC PF06314.11 EXF80183.1 - 6.2e-17 62.0 0.0 1.2e-16 61.0 0.0 1.5 1 0 0 1 1 1 1 Acetoacetate decarboxylase (ADC) NAD_binding_8 PF13450.6 EXF80183.1 - 2.3e-06 27.7 0.9 5.2e-06 26.6 0.1 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EXF80183.1 - 3.9e-05 23.0 1.0 0.00016 21.0 1.0 1.8 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EXF80183.1 - 4.3e-05 23.3 2.2 5.2e-05 23.0 1.1 1.5 1 1 0 1 1 1 1 FAD dependent oxidoreductase 3HCDH_N PF02737.18 EXF80183.1 - 0.016 15.1 0.1 0.029 14.3 0.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FAD_binding_2 PF00890.24 EXF80183.1 - 0.016 14.3 1.1 0.032 13.3 1.1 1.5 1 0 0 1 1 1 0 FAD binding domain GIDA PF01134.22 EXF80183.1 - 0.021 13.9 0.2 0.032 13.3 0.2 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A NAD_binding_9 PF13454.6 EXF80183.1 - 0.021 14.8 0.7 0.084 12.9 0.7 2.0 1 1 0 1 1 1 0 FAD-NAD(P)-binding FAD_oxidored PF12831.7 EXF80183.1 - 0.051 12.9 0.2 0.11 11.9 0.2 1.5 1 0 0 1 1 1 0 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EXF80183.1 - 0.099 11.9 0.0 0.16 11.2 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EXF80183.1 - 0.099 11.3 0.1 0.16 10.7 0.1 1.2 1 0 0 1 1 1 0 HI0933-like protein Pyr_redox PF00070.27 EXF80183.1 - 0.14 12.7 0.1 0.55 10.8 0.1 2.1 2 0 0 2 2 1 0 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.16 EXF80183.1 - 0.17 11.5 0.3 0.33 10.6 0.3 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Cupin_2 PF07883.11 EXF80184.1 - 3.2e-08 33.2 0.1 8.6e-08 31.8 0.0 1.8 2 0 0 2 2 2 1 Cupin domain Cupin_1 PF00190.22 EXF80184.1 - 0.00028 20.5 0.0 0.0004 20.0 0.0 1.2 1 0 0 1 1 1 1 Cupin Cupin_3 PF05899.12 EXF80184.1 - 0.0027 17.4 0.1 0.0046 16.6 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF861) ABC_membrane PF00664.23 EXF80185.1 - 6.5e-88 294.9 34.9 6.5e-51 173.6 10.3 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EXF80185.1 - 1.1e-66 223.6 0.1 3.2e-33 115.2 0.1 3.3 2 1 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EXF80185.1 - 5.8e-15 55.3 7.7 5.7e-08 32.5 1.4 3.6 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 EXF80185.1 - 4.6e-09 36.4 0.1 3.2e-05 23.9 0.0 2.7 2 0 0 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 EXF80185.1 - 6.5e-08 33.1 1.5 0.0037 17.7 0.0 3.1 2 1 0 2 2 2 2 AAA ATPase domain AAA_15 PF13175.6 EXF80185.1 - 2.5e-07 30.8 0.4 0.011 15.5 0.1 2.3 2 0 0 2 2 2 2 AAA ATPase domain ABC_ATPase PF09818.9 EXF80185.1 - 3.4e-07 29.4 0.5 0.097 11.4 0.0 3.7 3 1 1 4 4 4 2 Predicted ATPase of the ABC class AAA_22 PF13401.6 EXF80185.1 - 1.1e-06 28.9 0.7 0.11 12.8 0.0 3.2 3 1 0 3 3 3 2 AAA domain AAA_29 PF13555.6 EXF80185.1 - 1.4e-06 27.9 1.9 0.0011 18.7 0.2 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_30 PF13604.6 EXF80185.1 - 3.7e-05 23.5 2.3 0.1 12.3 0.1 3.3 3 0 0 3 3 3 2 AAA domain ATP-synt_ab PF00006.25 EXF80185.1 - 6.9e-05 22.6 0.1 0.37 10.4 0.0 2.6 2 0 0 2 2 2 2 ATP synthase alpha/beta family, nucleotide-binding domain AAA PF00004.29 EXF80185.1 - 0.00016 22.1 1.9 11 6.4 0.3 4.6 4 1 0 4 4 4 0 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 EXF80185.1 - 0.00021 20.9 2.1 1 8.9 0.0 3.6 4 0 0 4 4 4 2 AAA domain AAA_21 PF13304.6 EXF80185.1 - 0.00037 20.4 0.1 0.6 9.9 0.0 2.8 3 0 0 3 3 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_5 PF07728.14 EXF80185.1 - 0.00078 19.5 0.2 2 8.4 0.0 3.3 4 0 0 4 4 3 1 AAA domain (dynein-related subfamily) DUF3987 PF13148.6 EXF80185.1 - 0.00084 18.5 0.2 0.0017 17.4 0.2 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3987) AAA_7 PF12775.7 EXF80185.1 - 0.0012 18.4 0.0 1.6 8.2 0.0 2.4 2 0 0 2 2 2 2 P-loop containing dynein motor region PRK PF00485.18 EXF80185.1 - 0.0012 18.6 0.1 0.88 9.3 0.0 2.4 2 0 0 2 2 2 2 Phosphoribulokinase / Uridine kinase family AAA_23 PF13476.6 EXF80185.1 - 0.0025 18.3 7.2 0.017 15.6 0.1 3.1 2 1 1 3 3 3 1 AAA domain SbcCD_C PF13558.6 EXF80185.1 - 0.0041 17.3 1.7 3.3 8.0 0.2 3.9 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_33 PF13671.6 EXF80185.1 - 0.0047 17.1 1.1 0.12 12.5 0.0 2.8 3 0 0 3 3 2 1 AAA domain AAA_14 PF13173.6 EXF80185.1 - 0.0054 16.8 0.5 1.4 9.0 0.1 3.2 3 0 0 3 3 3 1 AAA domain AAA_18 PF13238.6 EXF80185.1 - 0.013 16.0 0.1 1.5 9.4 0.0 2.6 2 0 0 2 2 2 0 AAA domain Rad17 PF03215.15 EXF80185.1 - 0.015 15.2 0.1 2.4 8.0 0.0 2.4 2 0 0 2 2 2 0 Rad17 P-loop domain NB-ARC PF00931.22 EXF80185.1 - 0.021 14.0 0.1 3.3 6.8 0.0 2.9 3 0 0 3 3 3 0 NB-ARC domain AAA_24 PF13479.6 EXF80185.1 - 0.022 14.5 0.2 8.2 6.1 0.0 2.5 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 EXF80185.1 - 0.023 14.0 0.9 6 6.1 0.1 2.8 3 0 0 3 3 2 0 Zeta toxin RNA_helicase PF00910.22 EXF80185.1 - 0.063 13.7 0.1 21 5.6 0.0 2.8 2 0 0 2 2 2 0 RNA helicase Synapsin_N PF10581.9 EXF80185.1 - 0.086 12.8 0.0 0.93 9.5 0.0 2.5 3 0 0 3 3 3 0 Synapsin N-terminal Roc PF08477.13 EXF80185.1 - 0.089 13.0 0.8 19 5.5 0.4 2.8 3 0 0 3 3 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_28 PF13521.6 EXF80185.1 - 0.1 12.8 0.0 14 5.9 0.0 2.5 2 0 0 2 2 2 0 AAA domain G-alpha PF00503.20 EXF80185.1 - 0.14 11.3 0.0 16 4.5 0.0 2.2 2 0 0 2 2 2 0 G-protein alpha subunit ATP_bind_1 PF03029.17 EXF80185.1 - 0.15 11.8 0.1 1.9 8.2 0.0 2.3 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein tRNA-synt_His PF13393.6 EXF80186.1 - 1.7e-39 135.9 0.0 3.8e-33 115.1 0.0 2.1 2 0 0 2 2 2 2 Histidyl-tRNA synthetase HGTP_anticodon PF03129.20 EXF80186.1 - 1.7e-11 44.1 0.0 3.2e-11 43.2 0.0 1.5 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2b PF00587.25 EXF80186.1 - 0.00011 22.3 0.0 0.00031 20.8 0.0 1.8 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon2 PF12745.7 EXF80186.1 - 0.0024 17.4 0.1 0.034 13.7 0.0 2.2 2 0 0 2 2 2 1 Anticodon binding domain of tRNAs Ldh_1_C PF02866.18 EXF80188.1 - 1.2e-45 155.5 0.0 2.5e-45 154.4 0.0 1.6 2 0 0 2 2 2 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.23 EXF80188.1 - 5.2e-44 149.7 0.1 1.5e-43 148.2 0.0 1.7 2 0 0 2 2 2 1 lactate/malate dehydrogenase, NAD binding domain 3Beta_HSD PF01073.19 EXF80188.1 - 2.8e-05 23.3 0.0 4.2e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Glyco_hydro_4 PF02056.16 EXF80188.1 - 0.082 12.5 0.1 0.44 10.1 0.1 2.0 1 1 1 2 2 2 0 Family 4 glycosyl hydrolase E1-E2_ATPase PF00122.20 EXF80189.1 - 3.1e-17 62.7 0.0 7.5e-17 61.4 0.0 1.7 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 EXF80189.1 - 2.1e-13 51.1 2.5 6.9e-08 33.0 2.1 3.0 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EXF80189.1 - 0.00045 20.2 2.1 0.00056 20.0 0.0 2.2 3 0 0 3 3 3 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EXF80189.1 - 0.024 14.4 0.1 0.29 10.8 0.1 2.5 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase DUF4059 PF13268.6 EXF80189.1 - 0.058 13.8 1.5 13 6.2 0.1 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4059) Uds1 PF15456.6 EXF80189.1 - 0.47 10.6 5.7 0.94 9.6 5.7 1.5 1 0 0 1 1 1 0 Up-regulated During Septation TRAUB PF08164.12 EXF80190.1 - 0.46 11.0 3.7 0.4 11.2 0.3 2.6 2 0 0 2 2 2 0 Apoptosis-antagonizing transcription factor, C-terminal SIR2 PF02146.17 EXF80191.1 - 1.5e-31 109.7 0.0 8.6e-11 42.1 0.0 3.2 3 0 0 3 3 3 3 Sir2 family CCDC117 PF15810.5 EXF80191.1 - 0.038 14.3 1.1 0.22 11.8 1.1 2.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 117 GH131_N PF18271.1 EXF80192.1 - 2.4e-81 273.2 0.5 2.7e-81 273.0 0.5 1.0 1 0 0 1 1 1 1 Glycoside hydrolase 131 catalytic N-terminal domain Sugar_tr PF00083.24 EXF80193.1 - 3.1e-84 283.5 23.2 3.5e-84 283.2 23.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF80193.1 - 4.9e-18 65.2 36.0 9.5e-16 57.7 28.6 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Phage_holin_2_4 PF16082.5 EXF80193.1 - 0.31 10.8 1.2 1.2 8.9 0.1 2.3 2 0 0 2 2 2 0 Bacteriophage holin family, superfamily II-like Fungal_trans PF04082.18 EXF80194.1 - 3.3e-13 49.3 0.0 5e-13 48.7 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF80194.1 - 0.016 15.3 9.2 0.016 15.3 9.2 2.4 2 0 0 2 2 2 0 Fungal Zn(2)-Cys(6) binuclear cluster domain UBM PF14377.6 EXF80194.1 - 0.12 11.8 0.0 0.4 10.2 0.0 2.0 1 0 0 1 1 1 0 Ubiquitin binding region Melibiase_2 PF16499.5 EXF80195.1 - 1.4e-60 204.9 5.7 3.3e-59 200.4 5.7 2.2 1 1 0 1 1 1 1 Alpha galactosidase A Melibiase_C PF17801.1 EXF80195.1 - 4.9e-13 48.9 0.5 2.2e-10 40.5 0.0 3.3 3 0 0 3 3 3 2 Alpha galactosidase C-terminal beta sandwich domain Melibiase PF02065.18 EXF80195.1 - 7.1e-08 31.8 0.0 1.3e-07 30.9 0.0 1.4 1 1 0 1 1 1 1 Melibiase MDM31_MDM32 PF08118.11 EXF80197.1 - 2.9e-250 831.4 0.0 4.1e-250 830.9 0.0 1.2 1 0 0 1 1 1 1 Yeast mitochondrial distribution and morphology (MDM) proteins KH_8 PF17903.1 EXF80198.1 - 0.00092 19.3 0.0 0.002 18.2 0.0 1.5 1 0 0 1 1 1 1 Krr1 KH1 domain KH_1 PF00013.29 EXF80198.1 - 0.0037 17.1 0.8 0.0074 16.1 0.8 1.5 1 0 0 1 1 1 1 KH domain eIF-3_zeta PF05091.12 EXF80199.1 - 9.9e-202 671.5 0.0 1.2e-201 671.3 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF569 PF04601.13 EXF80199.1 - 0.077 12.7 0.0 0.18 11.5 0.0 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF569) NARG2_C PF10505.9 EXF80199.1 - 0.15 11.6 0.0 2.2 7.8 0.0 2.1 2 0 0 2 2 2 0 NMDA receptor-regulated gene protein 2 C-terminus PAP1 PF08601.10 EXF80200.1 - 0.12 12.0 0.0 0.16 11.6 0.0 1.1 1 0 0 1 1 1 0 Transcription factor PAP1 bZIP_1 PF00170.21 EXF80201.1 - 1.8e-05 24.7 8.4 1.8e-05 24.7 8.4 1.7 2 0 0 2 2 2 1 bZIP transcription factor Rsbr_N PF08678.10 EXF80201.1 - 0.16 12.0 0.1 0.26 11.4 0.1 1.3 1 0 0 1 1 1 0 Rsbr N terminal bZIP_2 PF07716.15 EXF80201.1 - 0.75 9.9 11.3 5.3 7.2 11.3 2.2 1 1 0 1 1 1 0 Basic region leucine zipper Acyltransferase PF01553.21 EXF80202.1 - 5.8e-15 55.1 0.0 8.2e-15 54.6 0.0 1.2 1 0 0 1 1 1 1 Acyltransferase Acyltransf_C PF16076.5 EXF80202.1 - 6e-08 32.7 0.0 1.8e-07 31.2 0.0 1.7 1 0 0 1 1 1 1 Acyltransferase C-terminus LAL_C2 PF18603.1 EXF80202.1 - 0.0038 17.4 0.0 0.026 14.6 0.0 2.1 2 0 0 2 2 2 1 L-amino acid ligase C-terminal domain 2 Pkinase PF00069.25 EXF80203.1 - 9.2e-61 205.5 0.0 5.2e-38 130.9 0.1 2.4 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EXF80203.1 - 4.9e-28 98.1 0.0 2.9e-20 72.7 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Response_reg PF00072.24 EXF80203.1 - 1.1e-15 57.8 0.0 2.1e-15 56.8 0.0 1.5 1 0 0 1 1 1 1 Response regulator receiver domain Kinase-like PF14531.6 EXF80203.1 - 6.6e-06 25.7 0.1 0.0029 17.0 0.0 2.9 3 0 0 3 3 3 2 Kinase-like APH PF01636.23 EXF80203.1 - 8.4e-05 22.6 0.0 0.0029 17.6 0.1 2.9 2 1 1 3 3 3 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EXF80203.1 - 0.011 14.7 0.1 0.019 13.9 0.1 1.3 1 0 0 1 1 1 0 Haspin like kinase domain PAS_9 PF13426.7 EXF80203.1 - 0.016 15.4 0.0 0.053 13.8 0.0 1.9 1 0 0 1 1 1 0 PAS domain Kdo PF06293.14 EXF80203.1 - 0.073 12.4 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 EXF80203.1 - 0.074 12.1 0.1 0.13 11.3 0.1 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 PAS PF00989.25 EXF80203.1 - 0.19 11.7 0.0 0.75 9.8 0.0 2.0 1 1 1 2 2 2 0 PAS fold Sugar_tr PF00083.24 EXF80204.1 - 3e-24 85.7 27.3 1e-15 57.5 9.7 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter Peptidase_S10 PF00450.22 EXF80205.1 - 3.2e-75 254.1 0.6 4.2e-75 253.7 0.6 1.2 1 0 0 1 1 1 1 Serine carboxypeptidase Lum_binding PF00677.17 EXF80206.1 - 6.7e-44 147.8 0.4 3.4e-21 75.0 0.0 2.1 2 0 0 2 2 2 2 Lumazine binding domain ERCC4 PF02732.15 EXF80207.1 - 7.2e-25 88.0 0.0 1.1e-24 87.4 0.0 1.3 1 0 0 1 1 1 1 ERCC4 domain HHH_8 PF14716.6 EXF80207.1 - 0.0051 17.2 0.0 0.012 15.9 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix domain HTH_27 PF13463.6 EXF80207.1 - 0.042 14.3 0.0 0.19 12.3 0.0 2.2 1 0 0 1 1 1 0 Winged helix DNA-binding domain HTH_45 PF14947.6 EXF80207.1 - 0.059 13.4 0.1 0.26 11.3 0.1 2.2 2 0 0 2 2 2 0 Winged helix-turn-helix PGM_PMM_I PF02878.16 EXF80208.1 - 4e-18 65.5 0.1 8e-08 32.1 0.0 2.8 1 1 1 2 2 2 2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_IV PF00408.20 EXF80208.1 - 8e-11 42.0 0.7 3.8e-10 39.8 0.3 2.3 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain PGM_PMM_III PF02880.16 EXF80208.1 - 0.00072 19.7 0.0 0.0019 18.3 0.0 1.8 1 1 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 EXF80208.1 - 0.0027 18.3 0.7 0.062 13.9 0.7 2.9 1 1 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II Arc PF03869.14 EXF80209.1 - 0.48 10.3 6.5 2.3 8.1 0.2 2.9 2 0 0 2 2 2 0 Arc-like DNA binding domain TetR_C_11 PF16859.5 EXF80209.1 - 1 9.7 11.8 0.11 12.8 5.2 2.8 3 0 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain Filament PF00038.21 EXF80209.1 - 1.1 8.8 80.1 0.02 14.5 11.2 5.9 4 2 0 5 5 5 0 Intermediate filament protein Zn_clus PF00172.18 EXF80210.1 - 4e-07 30.1 9.8 6.6e-07 29.3 9.8 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Lipase_3 PF01764.25 EXF80211.1 - 2.8e-20 72.6 0.0 1.2e-19 70.6 0.0 1.9 1 1 1 2 2 2 1 Lipase (class 3) DUF1772 PF08592.11 EXF80213.1 - 4.7e-15 56.1 1.2 1.2e-14 54.8 0.1 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF1772) Zn_clus PF00172.18 EXF80213.1 - 1.7e-08 34.5 10.1 2.5e-08 33.9 10.1 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EXF80213.1 - 1.7e-08 33.9 1.5 2.8e-08 33.1 1.5 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Filament_head PF04732.14 EXF80213.1 - 6 7.8 9.9 11 6.9 0.0 2.3 1 1 1 2 2 2 0 Intermediate filament head (DNA binding) region NmrA PF05368.13 EXF80214.1 - 3.4e-22 79.2 0.0 4.5e-22 78.8 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EXF80214.1 - 2.3e-13 50.4 0.7 1.2e-12 48.1 0.1 1.9 2 0 0 2 2 2 1 NAD(P)H-binding Epimerase PF01370.21 EXF80214.1 - 0.00013 21.5 0.3 0.0054 16.2 0.2 2.6 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family Shikimate_DH PF01488.20 EXF80214.1 - 0.0011 19.0 0.5 0.012 15.6 0.0 2.1 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase KR PF08659.10 EXF80214.1 - 0.0035 17.3 0.0 0.0074 16.2 0.0 1.5 1 0 0 1 1 1 1 KR domain F420_oxidored PF03807.17 EXF80214.1 - 0.004 17.7 0.4 0.012 16.2 0.1 1.9 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent Semialdhyde_dh PF01118.24 EXF80214.1 - 0.13 12.7 0.5 0.63 10.5 0.2 2.2 2 1 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain MFS_1 PF07690.16 EXF80215.1 - 6.7e-34 117.3 35.2 1.7e-33 116.0 35.0 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 EXF80215.1 - 0.00025 20.1 10.4 0.00025 20.1 10.4 1.5 1 1 0 1 1 1 1 MFS_1 like family 7tm_1 PF00001.21 EXF80217.1 - 0.00036 19.9 0.6 0.00075 18.9 0.6 1.5 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) ECSCR PF15820.5 EXF80217.1 - 5.3 6.9 6.8 28 4.6 0.2 3.1 2 1 1 3 3 3 0 Endothelial cell-specific chemotaxis regulator ATP-synt_8 PF00895.20 EXF80217.1 - 6.3 7.3 5.1 5.4 7.6 0.4 2.6 2 0 0 2 2 2 0 ATP synthase protein 8 FAD_binding_3 PF01494.19 EXF80218.1 - 2.3e-17 63.3 0.0 6.3e-09 35.5 0.0 2.3 2 1 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 EXF80218.1 - 0.00013 22.1 0.0 0.00029 21.0 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EXF80218.1 - 0.0012 18.1 0.0 0.22 10.7 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EXF80218.1 - 0.021 14.5 0.1 0.039 13.5 0.1 1.5 1 1 0 1 1 1 0 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EXF80218.1 - 0.045 13.0 0.0 2.2 7.5 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EXF80218.1 - 0.065 12.5 0.0 0.11 11.7 0.0 1.3 1 0 0 1 1 1 0 Thi4 family Lycopene_cycl PF05834.12 EXF80218.1 - 0.18 10.9 0.0 2 7.4 0.0 2.1 2 0 0 2 2 2 0 Lycopene cyclase protein PKD_channel PF08016.12 EXF80219.1 - 0.059 12.0 4.6 0.037 12.7 0.5 2.0 1 1 0 2 2 2 0 Polycystin cation channel Acyl-CoA_dh_1 PF00441.24 EXF80220.1 - 6.6e-31 107.5 3.6 9e-31 107.1 3.6 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 EXF80220.1 - 1.1e-22 80.9 0.0 2.2e-22 79.8 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 EXF80220.1 - 3.6e-21 75.2 0.1 5.9e-21 74.5 0.1 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain zf-MYND PF01753.18 EXF80221.1 - 1.9e-07 31.0 13.6 4.8e-07 29.8 13.6 1.7 1 0 0 1 1 1 1 MYND finger CHAT PF12770.7 EXF80224.1 - 9.6e-36 123.7 0.0 1.6e-35 122.9 0.0 1.4 1 0 0 1 1 1 1 CHAT domain TPR_17 PF13431.6 EXF80224.1 - 0.12 12.8 1.7 3.2 8.3 0.0 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_10 PF13374.6 EXF80224.1 - 0.17 11.8 9.3 1.1 9.2 0.0 6.2 7 1 0 7 7 7 0 Tetratricopeptide repeat TPR_8 PF13181.6 EXF80224.1 - 3.5 8.1 7.7 81 3.8 0.0 5.6 7 0 0 7 7 7 0 Tetratricopeptide repeat Dehydratase_hem PF13816.6 EXF80226.1 - 1.3e-113 379.5 0.1 1.5e-113 379.3 0.1 1.0 1 0 0 1 1 1 1 Haem-containing dehydratase DUF4188 PF13826.6 EXF80226.1 - 3.7e-06 27.3 0.0 0.059 13.7 0.1 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF4188) DUF4400 PF14348.6 EXF80226.1 - 0.079 12.4 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4400) PRT_C PF08372.10 EXF80227.1 - 0.061 13.1 0.2 0.093 12.5 0.2 1.2 1 0 0 1 1 1 0 Plant phosphoribosyltransferase C-terminal PfkB PF00294.24 EXF80228.1 - 7.1e-13 48.5 0.0 2.1e-12 47.0 0.0 1.6 1 1 0 1 1 1 1 pfkB family carbohydrate kinase GHMP_kinases_N PF00288.26 EXF80229.1 - 1.1e-09 38.4 0.0 2.2e-09 37.4 0.0 1.5 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 EXF80229.1 - 0.00018 21.8 0.0 0.00041 20.7 0.0 1.6 1 0 0 1 1 1 1 GHMP kinases C terminal Cerato-platanin PF07249.12 EXF80230.1 - 1.3e-58 196.3 3.3 1.4e-58 196.1 3.3 1.0 1 0 0 1 1 1 1 Cerato-platanin HEAT PF02985.22 EXF80231.1 - 6.9e-14 50.8 1.8 0.0044 17.2 0.1 7.9 7 0 0 7 7 7 2 HEAT repeat HEAT_2 PF13646.6 EXF80231.1 - 1.6e-10 41.2 13.0 0.088 13.2 0.0 7.7 6 1 3 9 9 9 4 HEAT repeats HEAT_EZ PF13513.6 EXF80231.1 - 5.1e-09 36.5 13.8 0.00051 20.5 0.1 7.8 7 2 1 9 9 8 3 HEAT-like repeat Cnd1 PF12717.7 EXF80231.1 - 9.2e-08 32.3 2.7 0.0012 19.0 0.0 3.9 4 0 0 4 4 4 2 non-SMC mitotic condensation complex subunit 1 IBN_N PF03810.19 EXF80231.1 - 5.2e-06 26.3 1.1 2.5e-05 24.1 0.3 2.6 2 0 0 2 2 2 1 Importin-beta N-terminal domain RIX1 PF08167.12 EXF80231.1 - 1.8e-05 24.6 0.0 1.8 8.3 0.0 3.6 3 0 0 3 3 3 2 rRNA processing/ribosome biogenesis CLASP_N PF12348.8 EXF80231.1 - 0.00016 21.3 0.1 0.0026 17.4 0.0 3.0 3 0 0 3 3 3 1 CLASP N terminal Adaptin_N PF01602.20 EXF80231.1 - 0.00027 19.6 0.0 0.14 10.7 0.0 2.9 2 0 0 2 2 2 2 Adaptin N terminal region Arm PF00514.23 EXF80231.1 - 0.0014 18.6 6.7 4.4 7.5 0.1 6.3 7 0 0 7 7 7 1 Armadillo/beta-catenin-like repeat Vac14_Fab1_bd PF12755.7 EXF80231.1 - 0.0017 18.9 0.0 0.75 10.4 0.0 3.7 3 0 0 3 3 3 1 Vacuolar 14 Fab1-binding region IFRD PF05004.13 EXF80231.1 - 0.0063 15.7 2.7 2 7.5 0.0 4.2 3 1 1 4 4 4 1 Interferon-related developmental regulator (IFRD) Tti2 PF10521.9 EXF80231.1 - 0.024 14.2 0.0 6.8 6.1 0.0 2.9 2 0 0 2 2 2 0 Tti2 family RTP1_C1 PF10363.9 EXF80231.1 - 0.055 13.7 1.2 1.3 9.2 0.0 3.2 3 0 0 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 Alpha-amylase PF00128.24 EXF80234.1 - 2.2e-108 362.8 0.0 3.1e-108 362.3 0.0 1.2 1 0 0 1 1 1 1 Alpha amylase, catalytic domain DUF4434 PF14488.6 EXF80234.1 - 0.02 14.9 0.0 0.036 14.1 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4434) hDGE_amylase PF14701.6 EXF80234.1 - 0.066 12.3 0.0 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 Glycogen debranching enzyme, glucanotransferase domain Sugar_tr PF00083.24 EXF80235.1 - 2.4e-84 283.8 19.9 2.8e-84 283.6 19.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF80235.1 - 7.2e-18 64.6 23.7 2.5e-16 59.5 18.2 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Folate_carrier PF01770.18 EXF80235.1 - 4.5e-05 22.4 0.1 9.3e-05 21.3 0.1 1.5 1 0 0 1 1 1 1 Reduced folate carrier MFS_2 PF13347.6 EXF80235.1 - 0.00022 19.9 22.5 0.013 14.1 7.6 2.9 2 1 1 3 3 3 2 MFS/sugar transport protein COX7C PF02935.16 EXF80235.1 - 9.4 6.6 7.9 60 4.0 3.0 2.9 2 0 0 2 2 2 0 Cytochrome c oxidase subunit VIIc Zn_clus PF00172.18 EXF80236.1 - 0.015 15.4 8.3 0.025 14.7 8.3 1.3 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-U1 PF06220.12 EXF80237.1 - 4e-07 29.7 0.2 6.5e-07 29.0 0.2 1.4 1 0 0 1 1 1 1 U1 zinc finger NTP_transferase PF00483.23 EXF80241.1 - 2.4e-31 109.2 0.0 3e-31 108.9 0.0 1.2 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep PF00132.24 EXF80241.1 - 1.1e-10 40.8 5.4 1.5e-06 27.7 0.0 3.6 3 0 0 3 3 3 3 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.7 EXF80241.1 - 5.4e-06 26.9 0.0 7.9e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain Dynamin_N PF00350.23 EXF80242.1 - 4.4e-22 78.9 0.0 4.2e-21 75.7 0.0 2.5 1 1 0 1 1 1 1 Dynamin family Dynamin_M PF01031.20 EXF80242.1 - 8.7e-16 58.0 4.4 7.1e-08 32.0 0.7 2.3 2 0 0 2 2 2 2 Dynamin central region GED PF02212.18 EXF80242.1 - 1.7e-05 24.9 0.0 6.7e-05 23.0 0.0 2.0 1 0 0 1 1 1 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 EXF80242.1 - 0.00044 20.3 0.0 0.0049 16.9 0.0 2.5 2 1 0 2 2 2 1 50S ribosome-binding GTPase Halo_GVPC PF05465.13 EXF80242.1 - 0.82 10.0 3.2 2.4 8.5 3.2 1.8 1 0 0 1 1 1 0 Halobacterial gas vesicle protein C (GVPC) repeat Sugar_tr PF00083.24 EXF80243.1 - 1.4e-80 271.3 20.3 1.7e-80 271.1 20.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF80243.1 - 3.8e-26 91.8 18.9 5.4e-26 91.3 18.9 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_2 PF13347.6 EXF80243.1 - 7e-05 21.6 0.6 7e-05 21.6 0.6 2.8 3 0 0 3 3 3 2 MFS/sugar transport protein PTR2 PF00854.21 EXF80243.1 - 0.00077 18.4 2.4 0.00077 18.4 2.4 2.0 2 0 0 2 2 2 1 POT family UNC-93 PF05978.16 EXF80243.1 - 0.0059 16.3 2.4 0.0059 16.3 2.4 2.4 3 0 0 3 3 3 1 Ion channel regulatory protein UNC-93 ABC2_membrane PF01061.24 EXF80244.1 - 7.5e-72 241.1 63.0 2.5e-37 128.3 22.2 2.8 3 0 0 3 3 3 2 ABC-2 type transporter ABC_tran PF00005.27 EXF80244.1 - 1.3e-35 122.9 0.0 7.1e-17 62.2 0.0 2.6 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.12 EXF80244.1 - 1.1e-26 92.5 0.1 8.6e-23 80.1 0.0 3.1 2 0 0 2 2 2 2 CDR ABC transporter ABC_trans_N PF14510.6 EXF80244.1 - 2.9e-17 63.1 0.7 3.1e-16 59.8 0.3 2.7 2 0 0 2 2 2 1 ABC-transporter N-terminal AAA_33 PF13671.6 EXF80244.1 - 4.1e-07 30.2 0.0 0.0085 16.3 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EXF80244.1 - 8.8e-07 29.5 0.2 0.021 15.2 0.0 2.9 3 0 0 3 3 3 2 AAA ATPase domain AAA_21 PF13304.6 EXF80244.1 - 8.1e-06 25.9 0.0 0.19 11.5 0.0 2.6 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_17 PF13207.6 EXF80244.1 - 9.8e-06 26.0 0.0 0.038 14.4 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 EXF80244.1 - 1.9e-05 25.2 0.0 0.011 16.3 0.0 2.7 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 EXF80244.1 - 8.8e-05 22.5 0.1 0.0011 19.0 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_29 PF13555.6 EXF80244.1 - 0.00015 21.4 0.3 0.012 15.3 0.1 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_25 PF13481.6 EXF80244.1 - 0.00018 21.1 0.4 0.015 14.8 0.1 2.5 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EXF80244.1 - 0.00075 19.8 0.1 0.31 11.3 0.0 2.8 2 0 0 2 2 2 1 AAA domain SMC_N PF02463.19 EXF80244.1 - 0.0019 17.7 0.0 0.72 9.2 0.0 3.4 3 0 0 3 3 3 1 RecF/RecN/SMC N terminal domain NACHT PF05729.12 EXF80244.1 - 0.0033 17.4 0.8 2.1 8.2 0.0 2.4 2 0 0 2 2 2 2 NACHT domain AAA_28 PF13521.6 EXF80244.1 - 0.012 15.9 1.5 0.11 12.7 0.0 2.7 3 0 0 3 3 2 0 AAA domain cobW PF02492.19 EXF80244.1 - 0.014 15.0 1.7 0.38 10.3 0.3 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_30 PF13604.6 EXF80244.1 - 0.034 13.8 1.2 2.2 7.9 0.2 2.4 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.6 EXF80244.1 - 0.074 13.4 0.7 2.5 8.4 0.0 2.6 2 0 0 2 2 2 0 AAA domain DnaB_C PF03796.15 EXF80244.1 - 0.15 11.4 0.0 3 7.1 0.0 2.3 2 0 0 2 2 2 0 DnaB-like helicase C terminal domain AAA PF00004.29 EXF80244.1 - 0.2 12.1 0.2 36 4.8 0.2 3.0 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 EXF80244.1 - 0.29 10.8 1.0 16 5.1 0.1 2.6 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 EXF80244.1 - 0.42 10.6 1.5 5.8 6.9 0.2 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_23 PF13476.6 EXF80244.1 - 0.46 11.0 2.1 0.5 10.8 0.1 2.1 2 0 0 2 2 1 0 AAA domain p450 PF00067.22 EXF80245.1 - 8.3e-20 71.0 0.0 9.7e-20 70.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Amino_oxidase PF01593.24 EXF80247.1 - 2.7e-24 86.3 0.6 5.6e-23 81.9 0.6 2.4 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EXF80247.1 - 1.3e-14 54.1 0.1 3.7e-14 52.7 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EXF80247.1 - 2.1e-12 47.3 1.3 4.5e-11 42.9 1.3 2.6 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EXF80247.1 - 2.7e-09 36.7 0.1 1.6e-05 24.3 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EXF80247.1 - 2.2e-08 33.6 2.4 9.5e-05 21.6 2.8 2.2 2 0 0 2 2 2 2 FAD binding domain HI0933_like PF03486.14 EXF80247.1 - 1.8e-07 30.2 0.2 0.0015 17.3 0.9 2.1 2 0 0 2 2 2 2 HI0933-like protein FAD_oxidored PF12831.7 EXF80247.1 - 3.7e-05 23.3 0.0 0.0015 17.9 0.0 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EXF80247.1 - 0.00021 20.7 0.7 0.00043 19.6 0.7 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EXF80247.1 - 0.00079 19.9 2.7 0.36 11.4 1.1 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EXF80247.1 - 0.0015 17.8 0.4 0.0026 17.1 0.4 1.3 1 0 0 1 1 1 1 FAD binding domain NAD_binding_9 PF13454.6 EXF80247.1 - 0.0077 16.2 3.4 0.052 13.5 0.2 2.5 3 0 0 3 3 2 1 FAD-NAD(P)-binding Thi4 PF01946.17 EXF80247.1 - 0.0094 15.2 0.1 0.016 14.4 0.1 1.3 1 0 0 1 1 1 1 Thi4 family Lycopene_cycl PF05834.12 EXF80247.1 - 0.018 14.1 0.4 0.018 14.1 0.4 2.1 3 0 0 3 3 3 0 Lycopene cyclase protein GMC_oxred_N PF00732.19 EXF80247.1 - 0.02 14.3 0.1 1.8 7.8 0.0 2.2 2 0 0 2 2 2 0 GMC oxidoreductase Trp_halogenase PF04820.14 EXF80247.1 - 0.041 12.7 0.5 6.4 5.5 0.0 2.5 2 0 0 2 2 2 0 Tryptophan halogenase ApbA PF02558.16 EXF80247.1 - 0.047 13.3 1.0 0.099 12.3 1.0 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA GDI PF00996.18 EXF80247.1 - 0.089 11.3 0.1 0.9 8.0 0.0 2.3 3 0 0 3 3 3 0 GDP dissociation inhibitor XdhC_C PF13478.6 EXF80247.1 - 0.092 13.3 0.1 0.69 10.4 0.0 2.2 2 0 0 2 2 2 0 XdhC Rossmann domain GIDA PF01134.22 EXF80247.1 - 0.25 10.4 3.5 0.23 10.5 1.4 1.8 2 0 0 2 2 2 0 Glucose inhibited division protein A adh_short PF00106.25 EXF80247.1 - 0.27 10.7 0.6 0.45 9.9 0.6 1.3 1 0 0 1 1 1 0 short chain dehydrogenase SQS_PSY PF00494.19 EXF80248.1 - 1.2e-64 218.4 0.5 1.6e-64 217.9 0.5 1.1 1 0 0 1 1 1 1 Squalene/phytoene synthase 4HBT PF03061.22 EXF80249.1 - 4.7e-06 26.9 0.2 1.2e-05 25.6 0.2 1.6 1 0 0 1 1 1 1 Thioesterase superfamily FAD_binding_7 PF03441.14 EXF80250.1 - 1.4e-45 155.2 0.2 2.3e-45 154.6 0.2 1.2 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.18 EXF80250.1 - 4.3e-20 72.4 0.0 7.9e-20 71.5 0.0 1.4 1 0 0 1 1 1 1 DNA photolyase DUF2953 PF11167.8 EXF80251.1 - 0.1 12.7 0.8 0.15 12.2 0.4 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2953) Fungal_trans PF04082.18 EXF80252.1 - 1.1e-06 27.9 0.0 2.2e-06 26.9 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF80252.1 - 7.7e-06 25.9 9.8 2.1e-05 24.5 9.8 1.8 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ET PF01684.16 EXF80252.1 - 0.04 14.2 0.4 0.11 12.8 0.4 1.7 1 0 0 1 1 1 0 ET module Peptidase_M43 PF05572.13 EXF80254.1 - 2.4e-12 47.0 0.0 4.9e-12 46.0 0.0 1.5 1 0 0 1 1 1 1 Pregnancy-associated plasma protein-A DUF4953 PF16313.5 EXF80254.1 - 0.00046 19.5 0.0 0.00096 18.4 0.0 1.4 1 0 0 1 1 1 1 Met-zincin Reprolysin_5 PF13688.6 EXF80254.1 - 0.012 15.8 0.0 0.022 14.9 0.0 1.5 1 1 0 1 1 1 0 Metallo-peptidase family M12 Reprolysin_3 PF13582.6 EXF80254.1 - 0.028 15.0 0.2 0.064 13.8 0.2 1.8 1 1 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.24 EXF80254.1 - 0.11 12.3 0.5 0.22 11.3 0.3 1.4 1 1 0 1 1 1 0 Matrixin Acetyltransf_9 PF13527.7 EXF80255.1 - 8.4e-06 25.9 0.0 1.8e-05 24.8 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EXF80255.1 - 2.4e-05 24.5 0.0 0.00045 20.4 0.0 2.3 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_15 PF17013.5 EXF80255.1 - 0.0011 18.5 0.0 0.0016 17.9 0.0 1.2 1 0 0 1 1 1 1 Putative acetyl-transferase Acetyltransf_10 PF13673.7 EXF80255.1 - 0.0012 18.8 0.0 0.0023 17.8 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EXF80255.1 - 0.003 18.0 0.0 0.0059 17.0 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_13 PF13880.6 EXF80255.1 - 0.0093 15.9 0.0 0.024 14.6 0.0 1.7 1 0 0 1 1 1 1 ESCO1/2 acetyl-transferase Phosphodiest PF01663.22 EXF80257.1 - 6.3e-91 305.6 0.4 8.6e-91 305.2 0.4 1.2 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Ntox33 PF15533.6 EXF80257.1 - 0.013 15.9 4.3 0.046 14.2 4.3 1.9 1 0 0 1 1 1 0 Bacterial toxin 33 Sulfatase PF00884.23 EXF80257.1 - 0.074 12.4 0.0 0.48 9.8 0.0 2.1 2 0 0 2 2 2 0 Sulfatase EF-hand_8 PF13833.6 EXF80260.1 - 0.2 11.5 0.1 18 5.3 0.0 2.4 2 0 0 2 2 2 0 EF-hand domain pair GTP_EFTU PF00009.27 EXF80261.1 - 2.2e-54 184.0 0.1 3.3e-54 183.4 0.1 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EXF80261.1 - 2.3e-41 140.6 0.0 4.4e-41 139.7 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EXF80261.1 - 6.2e-15 55.4 2.7 6.2e-15 55.3 0.8 2.1 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EXF80261.1 - 0.00069 19.7 0.1 0.019 15.0 0.1 2.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.6 EXF80261.1 - 0.068 13.1 0.3 0.24 11.3 0.3 1.9 1 0 0 1 1 1 0 Elongation factor Tu domain 4 SLS PF14611.6 EXF80262.1 - 7.2e-30 104.5 5.9 1.5e-29 103.5 5.9 1.5 1 0 0 1 1 1 1 Mitochondrial inner-membrane-bound regulator SLH PF00395.20 EXF80262.1 - 0.13 12.3 0.0 0.39 10.8 0.0 1.8 1 0 0 1 1 1 0 S-layer homology domain MAGE PF01454.19 EXF80263.1 - 2.2e-63 213.8 0.1 3.1e-63 213.3 0.1 1.2 1 0 0 1 1 1 1 MAGE family SF3b10 PF07189.11 EXF80264.1 - 7.7e-37 125.3 0.0 8.6e-37 125.1 0.0 1.0 1 0 0 1 1 1 1 Splicing factor 3B subunit 10 (SF3b10) zf-C6H2 PF15801.5 EXF80265.1 - 0.00018 21.7 9.4 0.011 16.0 0.7 2.9 3 0 0 3 3 3 2 zf-MYND-like zinc finger, mRNA-binding zf-MYND PF01753.18 EXF80265.1 - 0.003 17.6 2.2 0.003 17.6 2.2 3.4 3 0 0 3 3 3 1 MYND finger IL3 PF02059.15 EXF80265.1 - 0.025 14.6 0.1 4.6 7.3 0.0 2.3 2 0 0 2 2 2 0 Interleukin-3 DUF2353 PF09789.9 EXF80265.1 - 0.087 12.2 6.6 0.18 11.1 6.6 1.4 1 0 0 1 1 1 0 Uncharacterized coiled-coil protein (DUF2353) Spore_III_AF PF09581.10 EXF80265.1 - 0.11 12.5 0.0 0.11 12.5 0.0 2.2 3 0 0 3 3 3 0 Stage III sporulation protein AF (Spore_III_AF) DUF4618 PF15397.6 EXF80265.1 - 1.2 8.5 7.2 0.11 11.9 2.7 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4618) FUSC PF04632.12 EXF80265.1 - 1.7 7.1 2.5 2.4 6.6 0.3 1.9 2 0 0 2 2 2 0 Fusaric acid resistance protein family Zn_clus PF00172.18 EXF80266.1 - 0.47 10.6 3.9 0.79 9.9 3.9 1.3 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain adh_short PF00106.25 EXF80267.1 - 3.4e-26 91.9 0.0 4e-16 59.1 0.0 2.8 2 1 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EXF80267.1 - 1.7e-17 63.8 0.1 3.6e-12 46.3 0.0 2.5 2 1 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF80267.1 - 0.00035 20.5 0.1 0.11 12.4 0.1 2.8 3 0 0 3 3 3 2 KR domain Epimerase PF01370.21 EXF80267.1 - 0.17 11.3 0.1 1.3 8.4 0.1 2.1 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family Ank_2 PF12796.7 EXF80268.1 - 3.5e-49 165.3 6.1 1.4e-15 57.6 0.0 4.8 1 1 4 5 5 5 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EXF80268.1 - 3.3e-40 135.6 6.5 2.6e-11 43.5 0.3 6.8 1 1 5 7 7 7 6 Ankyrin repeats (many copies) Ank_4 PF13637.6 EXF80268.1 - 3.9e-39 132.5 1.6 5.7e-13 49.1 0.0 5.9 3 2 3 6 6 6 6 Ankyrin repeats (many copies) Ank PF00023.30 EXF80268.1 - 4e-38 128.2 6.0 5.3e-07 29.8 0.0 7.9 8 0 0 8 8 8 6 Ankyrin repeat Ank_3 PF13606.6 EXF80268.1 - 1.5e-35 117.2 2.0 7e-05 22.9 0.0 8.4 9 0 0 9 9 9 7 Ankyrin repeat EccE PF11203.8 EXF80268.1 - 0.061 13.6 0.0 0.37 11.1 0.0 2.2 2 1 0 2 2 2 0 Putative type VII ESX secretion system translocon, EccE Kinesin PF00225.23 EXF80270.1 - 2.4e-105 352.1 3.0 2.4e-105 352.1 3.0 2.0 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 EXF80270.1 - 2.5e-56 189.8 0.2 7.5e-56 188.2 0.2 1.9 1 0 0 1 1 1 1 Microtubule binding Spc42p PF11544.8 EXF80270.1 - 0.022 14.8 1.2 0.022 14.8 1.2 3.3 3 0 0 3 3 3 0 Spindle pole body component Spc42p AAA_24 PF13479.6 EXF80270.1 - 0.026 14.2 0.0 0.077 12.7 0.0 1.8 1 0 0 1 1 1 0 AAA domain Filament PF00038.21 EXF80270.1 - 0.03 13.9 42.6 3.8 7.0 42.6 3.6 1 1 0 1 1 1 0 Intermediate filament protein AAA_16 PF13191.6 EXF80270.1 - 0.037 14.4 0.0 0.037 14.4 0.0 2.6 2 1 0 2 2 1 0 AAA ATPase domain SHE3 PF17078.5 EXF80270.1 - 0.1 12.3 34.3 0.023 14.4 10.9 2.7 1 1 1 2 2 2 0 SWI5-dependent HO expression protein 3 AAA_22 PF13401.6 EXF80270.1 - 0.12 12.6 1.2 0.58 10.4 0.0 2.6 2 0 0 2 2 2 0 AAA domain Phage_tail_T PF06223.12 EXF80270.1 - 0.17 12.4 1.5 5.2 7.7 0.3 2.6 2 0 0 2 2 2 0 Minor tail protein T WEMBL PF05701.11 EXF80270.1 - 0.19 10.4 39.9 0.0056 15.4 32.1 2.1 2 0 0 2 2 2 0 Weak chloroplast movement under blue light Uso1_p115_C PF04871.13 EXF80270.1 - 0.69 10.3 43.4 0.042 14.2 13.7 4.9 2 1 2 5 5 5 0 Uso1 / p115 like vesicle tethering protein, C terminal region DUF148 PF02520.17 EXF80270.1 - 1.5 9.0 11.6 0.11 12.6 0.8 3.4 1 1 2 3 3 3 0 Domain of unknown function DUF148 DUF3584 PF12128.8 EXF80270.1 - 2.1 5.7 40.4 0.51 7.8 33.9 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) DUF1664 PF07889.12 EXF80270.1 - 2.9 7.9 18.3 0.59 10.2 2.6 4.0 1 1 1 3 3 3 0 Protein of unknown function (DUF1664) Prefoldin PF02996.17 EXF80270.1 - 4.5 7.2 15.4 0.11 12.4 2.6 4.1 2 1 0 3 3 3 0 Prefoldin subunit DivIC PF04977.15 EXF80270.1 - 8.2 6.3 20.6 0.68 9.7 0.1 4.7 1 1 3 4 4 4 0 Septum formation initiator XhlA PF10779.9 EXF80270.1 - 8.6 6.7 15.8 1.3 9.3 2.9 4.4 2 2 1 3 3 3 0 Haemolysin XhlA Acyltransferase PF01553.21 EXF80271.1 - 4.9e-05 23.0 0.0 8.8e-05 22.1 0.0 1.4 1 0 0 1 1 1 1 Acyltransferase ILVD_EDD PF00920.21 EXF80272.1 - 2e-213 709.7 0.1 2.3e-213 709.5 0.1 1.0 1 0 0 1 1 1 1 Dehydratase family CLP_protease PF00574.23 EXF80273.1 - 5.6e-71 238.2 0.1 7.8e-71 237.7 0.1 1.1 1 0 0 1 1 1 1 Clp protease FMO-like PF00743.19 EXF80273.1 - 0.16 10.4 0.2 0.22 9.9 0.2 1.2 1 0 0 1 1 1 0 Flavin-binding monooxygenase-like Dynamin_N PF00350.23 EXF80275.1 - 1.1e-12 48.3 0.0 1.1e-12 48.3 0.0 2.7 3 1 0 3 3 3 1 Dynamin family AAA_16 PF13191.6 EXF80275.1 - 3.6e-05 24.2 0.1 0.0001 22.7 0.1 1.9 1 1 0 1 1 1 1 AAA ATPase domain KAP_NTPase PF07693.14 EXF80275.1 - 8.9e-05 21.9 0.1 0.03 13.6 0.0 3.0 3 0 0 3 3 3 2 KAP family P-loop domain MMR_HSR1 PF01926.23 EXF80275.1 - 0.00029 20.9 0.2 0.0069 16.5 0.1 3.0 2 1 0 2 2 2 1 50S ribosome-binding GTPase ABC_tran PF00005.27 EXF80275.1 - 0.016 15.7 0.2 0.069 13.7 0.0 2.2 2 0 0 2 2 2 0 ABC transporter RsgA_GTPase PF03193.16 EXF80275.1 - 0.021 14.7 0.2 0.079 12.9 0.0 2.0 2 0 0 2 2 2 0 RsgA GTPase DUF3482 PF11981.8 EXF80275.1 - 0.047 13.1 0.3 0.18 11.2 0.3 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3482) AAA_22 PF13401.6 EXF80275.1 - 0.13 12.6 0.2 4.3 7.6 0.0 3.2 3 1 1 4 4 4 0 AAA domain DUF1398 PF07166.11 EXF80275.1 - 0.13 12.3 0.4 0.49 10.5 0.4 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1398) BLYB PF05289.11 EXF80275.1 - 0.17 12.1 2.9 0.3 11.3 1.2 2.4 2 0 0 2 2 2 0 Borrelia hemolysin accessory protein Clr5 PF14420.6 EXF80276.1 - 1.4e-22 79.7 0.3 3.4e-22 78.4 0.3 1.7 1 0 0 1 1 1 1 Clr5 domain MecA PF05389.12 EXF80276.1 - 0.061 13.0 2.7 0.11 12.1 2.7 1.4 1 0 0 1 1 1 0 Negative regulator of genetic competence (MecA) Neur_chan_memb PF02932.16 EXF80276.1 - 0.69 9.9 5.1 1.2 9.1 5.1 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF2464 PF10240.9 EXF80276.1 - 1.3 8.5 8.5 2.5 7.6 8.5 1.4 1 0 0 1 1 1 0 Multivesicular body subunit 12 CPSF73-100_C PF11718.8 EXF80276.1 - 9 5.8 9.2 51 3.3 9.0 2.0 2 0 0 2 2 2 0 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term Presenilin PF01080.17 EXF80276.1 - 9.3 4.9 10.5 14 4.4 10.5 1.1 1 0 0 1 1 1 0 Presenilin MFS_1 PF07690.16 EXF80277.1 - 2.1e-28 99.3 22.4 2.1e-28 99.3 22.4 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily TMEM234 PF10639.9 EXF80277.1 - 0.21 11.6 2.3 3.8 7.6 0.6 2.6 2 0 0 2 2 2 0 Putative transmembrane family 234 Gly-zipper_Omp PF13488.6 EXF80277.1 - 0.35 10.9 5.5 12 6.0 0.1 2.9 2 0 0 2 2 2 0 Glycine zipper MBOAT PF03062.19 EXF80278.1 - 8.8e-35 120.7 19.5 9.1e-34 117.3 19.5 2.1 1 1 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family Pex14_N PF04695.13 EXF80278.1 - 0.03 15.0 0.1 2.9 8.5 0.0 2.4 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF3433 PF11915.8 EXF80279.1 - 1.1e-19 70.7 8.2 1.8e-17 63.6 0.3 3.9 5 0 0 5 5 5 2 Protein of unknown function (DUF3433) DUF3290 PF11694.8 EXF80279.1 - 0.095 12.7 0.4 0.36 10.8 0.4 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3290) FAR1 PF03101.15 EXF80280.1 - 1.6e-08 35.1 1.2 2.9e-08 34.3 0.3 1.8 2 0 0 2 2 2 1 FAR1 DNA-binding domain DnaJ PF00226.31 EXF80281.1 - 1.4e-21 76.3 1.0 5.1e-21 74.6 1.0 2.0 1 0 0 1 1 1 1 DnaJ domain Metallophos PF00149.28 EXF80283.1 - 4.4e-12 46.9 0.0 1e-11 45.8 0.0 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EXF80283.1 - 8.5e-06 26.1 0.0 0.0019 18.4 0.0 2.3 2 0 0 2 2 2 2 Calcineurin-like phosphoesterase superfamily domain Metallophos_3 PF14582.6 EXF80283.1 - 0.037 13.4 0.0 0.24 10.7 0.0 1.9 2 0 0 2 2 2 0 Metallophosphoesterase, calcineurin superfamily DUF3176 PF11374.8 EXF80285.1 - 1.4e-30 105.7 3.9 1.4e-30 105.7 3.9 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3176) Ytca PF17090.5 EXF80285.1 - 0.018 15.6 1.2 0.061 13.9 1.2 1.9 1 0 0 1 1 1 0 Uncharacterised protein family MgtE PF01769.16 EXF80285.1 - 0.036 14.4 1.1 10 6.5 0.1 2.6 2 0 0 2 2 2 0 Divalent cation transporter AltA1 PF16541.5 EXF80287.1 - 0.028 15.3 0.1 0.14 13.0 0.0 1.9 1 1 1 2 2 2 0 Alternaria alternata allergen 1 Peptidase_A25 PF03418.14 EXF80287.1 - 0.078 11.9 0.1 0.085 11.7 0.1 1.2 1 0 0 1 1 1 0 Germination protease Helo_like_N PF17111.5 EXF80288.1 - 6.5e-10 38.7 0.7 1.3e-09 37.7 0.7 1.5 1 1 0 1 1 1 1 Fungal N-terminal domain of STAND proteins Ank_2 PF12796.7 EXF80288.1 - 2.2e-07 31.3 0.4 3e-05 24.5 0.1 3.3 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank PF00023.30 EXF80288.1 - 6.7e-05 23.1 0.4 1.9 9.1 0.1 3.8 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.6 EXF80288.1 - 0.0029 18.2 1.4 0.68 10.6 0.0 3.3 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 EXF80288.1 - 0.041 14.2 0.3 21 5.6 0.0 3.1 3 0 0 3 3 3 0 Ankyrin repeats (many copies) Ank_3 PF13606.6 EXF80288.1 - 0.096 13.3 2.7 7 7.6 0.0 3.7 4 0 0 4 4 4 0 Ankyrin repeat DUF3431 PF11913.8 EXF80290.1 - 3.1e-16 59.8 0.0 4.4e-16 59.3 0.0 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF3431) CIF PF16374.5 EXF80290.1 - 0.0043 17.1 0.1 0.76 9.9 0.1 2.2 1 1 1 2 2 2 2 Cycle inhibiting factor (CIF) DUF3443 PF11925.8 EXF80291.1 - 0.12 11.1 0.0 0.15 10.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3443) MFS_1 PF07690.16 EXF80292.1 - 5.2e-36 124.3 34.7 6.3e-36 124.0 34.7 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Ytp1 PF10355.9 EXF80293.1 - 1e-67 228.3 18.8 1e-67 228.3 18.8 2.2 2 1 0 2 2 2 1 Protein of unknown function (Ytp1) DUF2427 PF10348.9 EXF80293.1 - 5.9e-32 109.6 4.6 5.9e-32 109.6 4.6 2.4 3 0 0 3 3 3 1 Domain of unknown function (DUF2427) Amidohydro_1 PF01979.20 EXF80296.1 - 1e-30 107.3 0.1 1.2e-30 107.0 0.1 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EXF80296.1 - 3.9e-07 29.9 0.4 2.3e-05 24.0 0.1 2.2 2 0 0 2 2 2 2 Amidohydrolase family ketoacyl-synt PF00109.26 EXF80297.1 - 4e-66 223.2 0.0 7e-66 222.4 0.0 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.10 EXF80297.1 - 2.2e-58 197.1 0.4 6.9e-58 195.5 0.0 2.1 2 0 0 2 2 2 1 KR domain Acyl_transf_1 PF00698.21 EXF80297.1 - 3.8e-40 138.4 0.0 6.1e-40 137.7 0.0 1.3 1 0 0 1 1 1 1 Acyl transferase domain PS-DH PF14765.6 EXF80297.1 - 6.9e-38 130.6 0.1 1.1e-37 129.9 0.1 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase Ketoacyl-synt_C PF02801.22 EXF80297.1 - 8.6e-37 125.8 0.0 2.1e-36 124.5 0.0 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Methyltransf_12 PF08242.12 EXF80297.1 - 3e-16 60.0 0.0 9e-16 58.4 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain ADH_zinc_N PF00107.26 EXF80297.1 - 4.2e-13 49.4 0.4 1.3e-12 47.9 0.4 1.8 1 0 0 1 1 1 1 Zinc-binding dehydrogenase KAsynt_C_assoc PF16197.5 EXF80297.1 - 3e-09 37.3 0.1 9.8e-08 32.5 0.1 2.6 1 1 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension adh_short PF00106.25 EXF80297.1 - 4.1e-09 36.2 0.2 2.3e-06 27.2 0.0 2.5 2 0 0 2 2 2 2 short chain dehydrogenase Methyltransf_25 PF13649.6 EXF80297.1 - 4.8e-09 36.8 0.0 2.5e-08 34.5 0.0 2.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF80297.1 - 6e-09 36.4 0.0 2.2e-08 34.7 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EXF80297.1 - 1.9e-08 34.3 0.0 4.5e-08 33.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF80297.1 - 3.6e-07 30.1 0.0 8.7e-07 28.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Thiolase_N PF00108.23 EXF80297.1 - 7.2e-06 25.6 0.0 1.4e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain ADH_zinc_N_2 PF13602.6 EXF80297.1 - 7.3e-06 27.1 0.0 0.062 14.3 0.1 3.3 2 1 1 3 3 3 2 Zinc-binding dehydrogenase PP-binding PF00550.25 EXF80297.1 - 0.0012 19.2 0.1 0.0049 17.2 0.0 2.2 2 0 0 2 2 2 1 Phosphopantetheine attachment site ACP_syn_III PF08545.10 EXF80297.1 - 0.0018 18.1 0.1 0.0066 16.3 0.1 2.0 1 0 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III adh_short_C2 PF13561.6 EXF80297.1 - 0.0019 17.8 0.1 0.1 12.2 0.0 2.4 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase Ubie_methyltran PF01209.18 EXF80297.1 - 0.065 12.5 0.0 0.54 9.5 0.0 2.1 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family NodS PF05401.11 EXF80297.1 - 0.12 11.9 0.0 0.26 10.9 0.0 1.5 1 0 0 1 1 1 0 Nodulation protein S (NodS) Methyltransf_12 PF08242.12 EXF80298.1 - 5e-09 36.8 0.0 1.2e-08 35.6 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF80298.1 - 1.5e-08 35.2 0.0 4.2e-08 33.7 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EXF80298.1 - 2.3e-08 34.0 0.0 3.9e-08 33.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF80298.1 - 6.7e-08 33.1 0.0 1.5e-07 32.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF80298.1 - 9.7e-06 25.5 0.0 2.6e-05 24.1 0.0 1.8 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.7 EXF80298.1 - 0.009 16.0 0.0 0.017 15.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Pox_MCEL PF03291.16 EXF80298.1 - 0.093 11.8 0.0 0.13 11.3 0.0 1.1 1 0 0 1 1 1 0 mRNA capping enzyme DUF4267 PF14087.6 EXF80299.1 - 1.6e-13 50.7 0.1 1.9e-13 50.5 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4267) p450 PF00067.22 EXF80300.1 - 1.9e-18 66.4 0.0 5.4e-16 58.4 0.0 2.1 1 1 1 2 2 2 2 Cytochrome P450 p450 PF00067.22 EXF80301.1 - 1.3e-50 172.6 0.0 1.7e-50 172.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Peptidase_M28 PF04389.17 EXF80302.1 - 4.8e-36 124.3 0.1 1.4e-35 122.8 0.0 1.7 2 0 0 2 2 2 1 Peptidase family M28 Peptidase_M20 PF01546.28 EXF80302.1 - 3.7e-05 23.5 0.0 0.00019 21.2 0.0 2.1 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M42 PF05343.14 EXF80302.1 - 8.3e-05 21.7 0.0 0.00019 20.6 0.0 1.6 1 1 0 1 1 1 1 M42 glutamyl aminopeptidase Nicastrin PF05450.15 EXF80302.1 - 0.036 13.5 0.0 0.064 12.7 0.0 1.4 1 0 0 1 1 1 0 Nicastrin DUF4910 PF16254.5 EXF80302.1 - 0.14 11.0 0.0 2.4 6.9 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4910) Ammonium_transp PF00909.21 EXF80303.1 - 1.8e-118 395.7 31.2 2.1e-118 395.5 31.2 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family Methyltransf_24 PF13578.6 EXF80304.1 - 9.7e-09 36.2 0.0 2.2e-08 35.1 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_3 PF01596.17 EXF80304.1 - 6.1e-06 25.6 0.0 8e-06 25.2 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase CmcI PF04989.12 EXF80304.1 - 0.049 13.3 0.0 0.17 11.5 0.0 1.7 1 1 0 2 2 2 0 Cephalosporin hydroxylase HTH_27 PF13463.6 EXF80304.1 - 0.12 12.9 0.0 0.24 11.9 0.0 1.4 1 0 0 1 1 1 0 Winged helix DNA-binding domain TFR_dimer PF04253.15 EXF80305.1 - 1.7e-27 95.9 0.0 2.8e-27 95.2 0.0 1.3 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.17 EXF80305.1 - 8.6e-20 71.3 0.0 1.5e-19 70.4 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 EXF80305.1 - 3.6e-12 46.1 0.0 1e-11 44.6 0.0 1.7 1 0 0 1 1 1 1 PA domain Peptidase_M20 PF01546.28 EXF80305.1 - 0.025 14.3 0.0 0.066 12.9 0.0 1.6 1 1 0 1 1 1 0 Peptidase family M20/M25/M40 Peptidase_M20 PF01546.28 EXF80306.1 - 3.6e-28 98.7 0.1 5.3e-28 98.1 0.1 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EXF80306.1 - 3.4e-06 26.9 0.0 6.9e-06 26.0 0.0 1.6 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 EXF80306.1 - 0.0073 16.0 0.1 0.019 14.7 0.1 1.8 1 0 0 1 1 1 1 Peptidase family M28 MFS_1 PF07690.16 EXF80307.1 - 2.6e-26 92.4 40.8 2.6e-26 92.4 40.8 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily DUF1180 PF06679.12 EXF80307.1 - 0.013 15.9 0.0 0.028 14.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) DUF3624 PF12292.8 EXF80307.1 - 0.17 12.3 0.3 0.17 12.3 0.3 3.3 4 0 0 4 4 4 0 Protein of unknown function (DUF3624) MFS_4 PF06779.14 EXF80307.1 - 0.36 10.1 29.4 26 4.0 29.4 2.5 1 1 0 1 1 1 0 Uncharacterised MFS-type transporter YbfB Phage_holin_5_2 PF16079.5 EXF80307.1 - 4.4 7.7 13.0 0.22 11.9 0.7 4.1 2 2 1 3 3 3 0 Phage holin family Hol44, in holin superfamily V DUF1230 PF06799.11 EXF80307.1 - 4.4 7.4 7.1 0.34 11.0 0.7 2.4 2 1 0 2 2 2 0 Conserved in the green lineage and diatoms 27 Saf_2TM PF18303.1 EXF80307.1 - 7.3 6.2 7.1 20 4.8 0.0 2.9 3 0 0 3 3 3 0 SAVED-fused 2TM effector domain F-box PF00646.33 EXF80308.1 - 0.0018 18.1 0.0 0.011 15.6 0.0 2.4 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 EXF80308.1 - 0.0019 18.0 0.0 0.0078 16.1 0.0 2.1 1 0 0 1 1 1 1 F-box-like Peptidase_M14 PF00246.24 EXF80309.1 - 1.7e-38 133.1 0.8 2.4e-38 132.6 0.8 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase ThuA PF06283.11 EXF80310.1 - 1.3e-60 205.2 0.3 6e-60 203.1 0.3 1.8 1 1 0 1 1 1 1 Trehalose utilisation PLDc_2 PF13091.6 EXF80311.1 - 1.3e-17 63.9 0.0 7.3e-13 48.6 0.0 2.6 2 1 0 2 2 2 2 PLD-like domain Regulator_TrmB PF11495.8 EXF80311.1 - 0.036 13.2 0.1 5.9 6.0 0.0 2.4 2 0 0 2 2 2 0 Archaeal transcriptional regulator TrmB PLDc PF00614.22 EXF80311.1 - 0.13 12.5 0.1 8.6 6.7 0.0 2.4 2 0 0 2 2 2 0 Phospholipase D Active site motif BAR PF03114.18 EXF80312.1 - 3.2e-49 167.7 3.3 3.9e-49 167.5 3.3 1.1 1 0 0 1 1 1 1 BAR domain BAR_2 PF10455.9 EXF80312.1 - 4.1e-07 29.4 0.8 5.2e-07 29.1 0.8 1.1 1 0 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking Ebp2 PF05890.12 EXF80312.1 - 0.00067 19.3 0.4 0.0013 18.4 0.4 1.4 1 0 0 1 1 1 1 Eukaryotic rRNA processing protein EBP2 OmpH PF03938.14 EXF80312.1 - 0.019 15.3 2.3 0.019 15.3 2.3 2.2 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) PMEI PF04043.15 EXF80312.1 - 0.037 14.4 0.2 0.067 13.5 0.2 1.4 1 0 0 1 1 1 0 Plant invertase/pectin methylesterase inhibitor TSNAXIP1_N PF15739.5 EXF80312.1 - 1.2 9.5 5.4 0.33 11.4 2.2 1.7 2 0 0 2 2 2 0 Translin-associated factor X-interacting N-terminus DUF883 PF05957.13 EXF80312.1 - 7.1 7.3 7.4 34 5.1 7.2 2.2 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF883) Cyclin_C_2 PF16899.5 EXF80313.1 - 2.3e-36 124.3 0.0 1.1e-33 115.7 0.0 2.5 2 0 0 2 2 2 2 Cyclin C-terminal domain Cyclin_N PF00134.23 EXF80313.1 - 0.00077 19.2 0.0 0.0016 18.2 0.0 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 EXF80313.1 - 0.035 14.2 0.4 3.6 7.7 0.0 3.1 4 0 0 4 4 4 0 Cyclin, C-terminal domain Fasciclin PF02469.22 EXF80314.1 - 6.7e-44 149.2 2.9 2.3e-23 82.8 0.6 2.2 2 0 0 2 2 2 2 Fasciclin domain MS_channel PF00924.18 EXF80315.1 - 1.7e-16 60.4 0.2 1.7e-16 60.4 0.2 1.6 2 0 0 2 2 2 1 Mechanosensitive ion channel EF-hand_7 PF13499.6 EXF80315.1 - 0.063 13.7 0.1 4.2 7.9 0.0 3.1 2 1 0 2 2 2 0 EF-hand domain pair AA_permease_2 PF13520.6 EXF80316.1 - 5e-85 285.9 20.6 6.4e-85 285.5 20.6 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EXF80316.1 - 3.3e-11 42.5 21.5 5.3e-11 41.8 21.5 1.2 1 0 0 1 1 1 1 Amino acid permease Aa_trans PF01490.18 EXF80316.1 - 0.064 12.0 13.3 0.3 9.7 13.3 2.5 1 1 0 1 1 1 0 Transmembrane amino acid transporter protein Glyco_hydro_3_C PF01915.22 EXF80318.1 - 4e-39 134.7 0.2 1.2e-38 133.1 0.0 1.9 2 0 0 2 2 2 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 EXF80318.1 - 1.1e-35 123.5 0.0 1.9e-35 122.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 EXF80318.1 - 9.4e-24 83.3 0.1 1.6e-23 82.6 0.1 1.4 1 0 0 1 1 1 1 Fibronectin type III-like domain Fungal_trans PF04082.18 EXF80319.1 - 1.7e-16 60.0 0.1 2.7e-16 59.4 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain RNA_pol_Rpb1_1 PF04997.12 EXF80320.1 - 2.2e-106 355.7 0.1 3.6e-106 355.0 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_5 PF04998.17 EXF80320.1 - 9e-101 336.8 0.0 1.4e-100 336.2 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 EXF80320.1 - 4.6e-76 254.7 0.0 8.5e-76 253.8 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_6 PF04992.14 EXF80320.1 - 2.1e-61 207.1 5.6 3.8e-61 206.3 5.6 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 6 RNA_pol_Rpb1_7 PF04990.12 EXF80320.1 - 1.1e-47 161.5 5.5 3.1e-47 160.0 5.3 2.0 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 7 RNA_pol_Rpb1_3 PF04983.18 EXF80320.1 - 9.3e-44 149.1 0.0 2.1e-43 147.9 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 EXF80320.1 - 5e-37 126.1 0.1 1.1e-36 125.0 0.1 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_R PF05001.13 EXF80320.1 - 0.025 14.9 187.6 0.24 11.8 11.6 12.7 7 2 3 11 11 11 0 RNA polymerase Rpb1 C-terminal repeat WD40 PF00400.32 EXF80321.1 - 1.5e-15 57.3 9.6 1e-05 26.1 0.3 5.3 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EXF80321.1 - 2.7e-10 40.4 0.6 0.00034 20.9 0.0 5.3 2 2 2 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EXF80321.1 - 2.5e-05 24.2 0.3 0.039 13.8 0.0 3.0 3 1 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A Thg1 PF04446.12 EXF80322.1 - 4.7e-53 178.5 0.0 7.1e-53 177.9 0.0 1.3 1 0 0 1 1 1 1 tRNAHis guanylyltransferase Thg1C PF14413.6 EXF80322.1 - 2.2e-49 166.7 0.4 3.4e-49 166.1 0.4 1.3 1 0 0 1 1 1 1 Thg1 C terminal domain Nop53 PF07767.11 EXF80323.1 - 0.021 14.2 16.5 0.025 14.0 16.5 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Asp-B-Hydro_N PF05279.11 EXF80323.1 - 0.7 9.9 15.2 0.95 9.5 15.2 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region DUF4407 PF14362.6 EXF80323.1 - 1.5 8.1 7.3 1.7 7.9 7.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SRP-alpha_N PF04086.13 EXF80323.1 - 1.7 8.5 15.2 2.8 7.8 15.2 1.3 1 1 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal HMGL-like PF00682.19 EXF80324.1 - 1.4e-79 267.4 0.3 2e-79 266.8 0.3 1.3 1 0 0 1 1 1 1 HMGL-like Bromodomain PF00439.25 EXF80325.1 - 2.9e-29 101.0 0.7 2.7e-14 53.0 0.0 2.5 2 0 0 2 2 2 2 Bromodomain Nop14 PF04147.12 EXF80325.1 - 0.00067 18.0 9.3 0.00094 17.5 9.3 1.2 1 0 0 1 1 1 1 Nop14-like family PPP4R2 PF09184.11 EXF80325.1 - 0.048 13.2 9.0 0.12 12.0 9.0 1.6 1 0 0 1 1 1 0 PPP4R2 CDC45 PF02724.14 EXF80325.1 - 0.16 10.2 11.3 0.24 9.6 11.3 1.2 1 0 0 1 1 1 0 CDC45-like protein CobT PF06213.12 EXF80325.1 - 0.36 10.2 15.5 0.73 9.2 15.5 1.4 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT FYDLN_acid PF09538.10 EXF80325.1 - 7.3 7.3 16.5 27 5.5 16.5 2.0 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) CKS PF01111.19 EXF80326.1 - 1.8e-34 117.8 1.5 2.4e-34 117.4 1.5 1.2 1 0 0 1 1 1 1 Cyclin-dependent kinase regulatory subunit ERO1 PF04137.15 EXF80327.1 - 7.6e-135 449.7 0.0 9.4e-135 449.3 0.0 1.1 1 0 0 1 1 1 1 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) HVSL PF09749.9 EXF80328.1 - 4.5e-79 265.3 0.0 5.6e-79 265.0 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised conserved protein Pal1 PF08316.11 EXF80329.1 - 2.2e-09 38.2 1.0 6e-09 36.8 0.0 2.2 2 1 0 2 2 2 1 Pal1 cell morphology protein CPSF_A PF03178.15 EXF80330.1 - 3.7e-81 272.9 0.0 8.9e-81 271.7 0.0 1.7 2 0 0 2 2 2 1 CPSF A subunit region MMS1_N PF10433.9 EXF80330.1 - 9.2e-16 57.5 0.0 3.3e-15 55.7 0.0 2.0 2 1 0 2 2 2 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term LMBR1 PF04791.16 EXF80331.1 - 1.8e-16 60.2 5.7 1.8e-16 60.2 5.7 2.3 1 1 1 2 2 2 2 LMBR1-like membrane protein TMEM208_SND2 PF05620.11 EXF80331.1 - 0.71 9.6 0.0 0.71 9.6 0.0 4.1 5 0 0 5 5 5 0 SRP-independent targeting protein 2/TMEM208 DUF5134 PF17197.4 EXF80331.1 - 3.1 7.7 5.9 13 5.7 2.9 3.0 2 1 0 2 2 2 0 Domain of unknown function (DUF5134) CEBP_ZZ PF16366.5 EXF80332.1 - 0.12 12.7 3.6 0.21 11.9 3.6 1.3 1 0 0 1 1 1 0 Cytoplasmic polyadenylation element-binding protein ZZ domain zf-B_box PF00643.24 EXF80332.1 - 0.5 10.6 3.4 0.84 9.8 3.4 1.3 1 0 0 1 1 1 0 B-box zinc finger UDG PF03167.19 EXF80334.1 - 3.9e-18 65.9 0.0 1.8e-17 63.8 0.0 2.0 2 1 0 2 2 2 1 Uracil DNA glycosylase superfamily POR_N PF01855.19 EXF80334.1 - 0.16 11.7 0.1 0.3 10.8 0.1 1.3 1 0 0 1 1 1 0 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg Glyco_hydro_47 PF01532.20 EXF80335.1 - 2.6e-116 389.3 0.0 3.4e-116 388.9 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 MFS_1 PF07690.16 EXF80336.1 - 9.1e-17 61.0 40.8 9.1e-17 61.0 40.8 3.0 1 1 2 3 3 3 2 Major Facilitator Superfamily PQ-loop PF04193.14 EXF80337.1 - 7.3e-41 137.8 8.3 5e-20 71.0 1.6 2.6 2 0 0 2 2 2 2 PQ loop repeat 7tm_1 PF00001.21 EXF80337.1 - 0.11 11.7 0.1 0.36 10.1 0.1 1.8 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) MtN3_slv PF03083.16 EXF80337.1 - 0.19 11.8 0.2 0.19 11.8 0.2 2.3 2 1 0 2 2 2 0 Sugar efflux transporter for intercellular exchange Isochorismatase PF00857.20 EXF80338.1 - 1.7e-23 83.7 0.0 2.6e-23 83.1 0.0 1.3 1 1 0 1 1 1 1 Isochorismatase family LpxI_N PF17930.1 EXF80338.1 - 0.057 13.3 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 LpxI N-terminal domain PRKG1_interact PF15898.5 EXF80339.1 - 0.0058 17.5 2.6 0.0058 17.5 2.6 2.8 3 1 0 3 3 3 1 cGMP-dependent protein kinase interacting domain PHD PF00628.29 EXF80339.1 - 0.0075 16.1 9.3 0.012 15.4 9.3 1.4 1 0 0 1 1 1 1 PHD-finger Cnn_1N PF07989.11 EXF80339.1 - 0.016 15.4 3.9 0.91 9.7 1.2 2.5 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 Zf_RING PF16744.5 EXF80339.1 - 0.2 11.8 8.1 1.4 9.0 5.1 2.4 1 1 1 2 2 2 0 KIAA1045 RING finger zf-HC5HC2H PF13771.6 EXF80339.1 - 0.54 10.5 8.9 1.2 9.5 8.9 1.5 1 0 0 1 1 1 0 PHD-like zinc-binding domain TMF_DNA_bd PF12329.8 EXF80339.1 - 1.4 9.0 8.7 25 4.9 5.7 2.7 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding C1_1 PF00130.22 EXF80339.1 - 6 6.8 14.9 0.46 10.4 5.5 2.4 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) HIP1_clath_bdg PF16515.5 EXF80339.1 - 7.1 7.3 15.4 4.6 7.9 3.9 2.8 2 1 1 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 MFS_1 PF07690.16 EXF80340.1 - 4.5e-26 91.6 50.2 2.9e-20 72.5 31.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily NUDIX PF00293.28 EXF80341.1 - 2.7e-16 59.8 0.0 5.6e-16 58.8 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain NUDIX-like PF09296.11 EXF80341.1 - 2.8e-14 53.6 0.0 1e-13 51.8 0.0 1.9 2 1 0 2 2 2 1 NADH pyrophosphatase-like rudimentary NUDIX domain zf-NADH-PPase PF09297.11 EXF80341.1 - 0.00037 20.1 0.4 0.00078 19.0 0.4 1.4 1 0 0 1 1 1 1 NADH pyrophosphatase zinc ribbon domain Arf PF00025.21 EXF80342.1 - 1.6e-40 138.4 0.0 2.5e-40 137.8 0.0 1.3 1 1 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 EXF80342.1 - 1.9e-15 56.9 0.0 2e-10 40.4 0.0 2.0 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 EXF80342.1 - 1.5e-10 40.9 0.0 6.5e-10 38.8 0.0 1.8 1 1 0 1 1 1 1 Ras family Roc PF08477.13 EXF80342.1 - 6e-10 39.4 0.0 1.3e-09 38.3 0.0 1.6 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 EXF80342.1 - 8.4e-08 31.8 0.0 1e-07 31.6 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 EXF80342.1 - 2.7e-07 30.2 0.0 1e-06 28.3 0.0 1.7 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 EXF80342.1 - 0.00014 21.5 0.3 0.00043 19.9 0.3 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EXF80342.1 - 0.00053 20.1 0.0 0.00081 19.4 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase NACHT PF05729.12 EXF80342.1 - 0.052 13.5 0.0 0.097 12.6 0.0 1.5 1 1 0 1 1 1 0 NACHT domain RNase_PH PF01138.21 EXF80343.1 - 9.3e-24 84.4 0.0 1.5e-23 83.7 0.0 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 EXF80343.1 - 4.4e-08 33.0 0.0 7.2e-08 32.4 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 Cwf_Cwc_15 PF04889.12 EXF80344.1 - 1.1e-87 293.9 22.3 1.2e-87 293.8 22.3 1.0 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein YL1 PF05764.13 EXF80344.1 - 0.004 17.3 21.7 0.0049 17.0 21.7 1.3 1 0 0 1 1 1 1 YL1 nuclear protein CDC27 PF09507.10 EXF80344.1 - 0.0048 16.4 14.8 0.0059 16.0 14.8 1.1 1 0 0 1 1 1 1 DNA polymerase subunit Cdc27 Nop14 PF04147.12 EXF80344.1 - 0.53 8.4 27.0 0.58 8.3 27.0 1.1 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 EXF80344.1 - 0.53 8.5 22.1 0.65 8.2 22.1 1.1 1 0 0 1 1 1 0 CDC45-like protein SDA1 PF05285.12 EXF80344.1 - 0.74 9.2 25.9 0.87 9.0 25.9 1.2 1 0 0 1 1 1 0 SDA1 Nop53 PF07767.11 EXF80344.1 - 1.2 8.5 23.5 1.8 7.9 23.5 1.2 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) RR_TM4-6 PF06459.12 EXF80344.1 - 3.1 7.5 10.0 4.3 7.1 10.0 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Hid1 PF12722.7 EXF80344.1 - 3.1 5.8 5.8 3.5 5.6 5.8 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF3381 PF11861.8 EXF80344.1 - 3.7 7.3 20.3 6.9 6.4 20.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) SAPS PF04499.15 EXF80344.1 - 5.7 5.6 10.6 6.8 5.4 10.6 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein RRN3 PF05327.11 EXF80344.1 - 7.3 5.0 13.3 8.4 4.8 13.3 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 adh_short PF00106.25 EXF80345.1 - 1.7e-36 125.5 2.5 4e-36 124.3 2.5 1.5 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF80345.1 - 5.6e-26 91.5 3.8 9.3e-26 90.8 3.8 1.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF80345.1 - 6.8e-14 52.2 2.2 9.1e-14 51.8 2.2 1.2 1 0 0 1 1 1 1 KR domain Sacchrp_dh_NADP PF03435.18 EXF80345.1 - 2.4e-07 31.1 0.3 1.2e-06 28.8 0.2 1.9 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain Epimerase PF01370.21 EXF80345.1 - 7.2e-07 28.9 0.2 1e-06 28.4 0.2 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EXF80345.1 - 0.0001 22.3 1.8 0.00015 21.8 1.0 1.6 2 0 0 2 2 2 1 NAD(P)H-binding Polysacc_synt_2 PF02719.15 EXF80345.1 - 0.00095 18.4 0.1 0.0015 17.7 0.1 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 EXF80345.1 - 0.0013 18.2 0.5 0.0044 16.5 0.5 1.8 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Semialdhyde_dh PF01118.24 EXF80345.1 - 0.057 13.9 0.1 0.12 12.8 0.1 1.6 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain Ras PF00071.22 EXF80348.1 - 6.9e-58 194.8 0.0 8.3e-58 194.6 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EXF80348.1 - 2.8e-34 117.9 0.0 4.4e-34 117.3 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EXF80348.1 - 2.3e-14 53.2 0.0 4.1e-14 52.4 0.0 1.4 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EXF80348.1 - 2.3e-06 27.3 0.0 4.4e-06 26.4 0.0 1.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EXF80348.1 - 3.4e-05 23.3 0.0 4.3e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EXF80348.1 - 9.1e-05 22.5 0.0 0.00015 21.8 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 EXF80348.1 - 0.00064 20.1 0.1 0.00087 19.7 0.1 1.4 1 1 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 EXF80348.1 - 0.016 15.1 0.1 2 8.3 0.0 2.3 2 1 0 2 2 2 0 RsgA GTPase AAA_22 PF13401.6 EXF80348.1 - 0.17 12.1 0.0 1.3 9.3 0.0 2.1 2 1 0 2 2 2 0 AAA domain Kri1 PF05178.12 EXF80349.1 - 8.3e-29 100.2 22.8 8.3e-29 100.2 22.8 5.3 5 1 0 5 5 5 1 KRI1-like family Kri1_C PF12936.7 EXF80349.1 - 6.1e-28 96.8 0.1 6.1e-28 96.8 0.1 4.0 4 0 0 4 4 4 1 KRI1-like family C-terminal fn3_3 PF14686.6 EXF80350.1 - 2.5e-27 94.4 1.2 6.8e-27 93.1 1.2 1.8 1 0 0 1 1 1 1 Polysaccharide lyase family 4, domain II CBM-like PF14683.6 EXF80350.1 - 2.6e-22 79.5 0.0 4.7e-22 78.6 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide lyase family 4, domain III Nudix_N PF12535.8 EXF80350.1 - 0.083 12.5 0.0 0.17 11.5 0.0 1.4 1 0 0 1 1 1 0 Hydrolase of X-linked nucleoside diphosphate N terminal DUF2220 PF09983.9 EXF80350.1 - 0.14 11.6 0.0 0.38 10.1 0.0 1.7 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria C-term(DUF2220) Glyco_hydro_76 PF03663.14 EXF80351.1 - 1.7e-42 146.3 18.1 1.3e-41 143.4 18.1 2.0 1 1 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 EXF80351.1 - 1.7e-06 27.4 0.9 0.038 13.1 0.0 2.9 2 1 1 3 3 3 2 Glycosyl Hydrolase Family 88 C5-epim_C PF06662.13 EXF80351.1 - 0.023 14.2 0.0 0.071 12.6 0.0 1.7 1 1 0 1 1 1 0 D-glucuronyl C5-epimerase C-terminus Zip PF02535.22 EXF80352.1 - 5.1e-30 104.8 3.5 2.3e-26 92.8 2.8 2.4 2 0 0 2 2 2 2 ZIP Zinc transporter WD40 PF00400.32 EXF80353.1 - 2.7e-37 126.1 22.1 1.9e-07 31.6 0.2 7.2 6 0 0 6 6 6 6 WD domain, G-beta repeat F-box-like PF12937.7 EXF80353.1 - 1.2e-12 47.5 0.9 2.4e-12 46.5 0.9 1.5 1 0 0 1 1 1 1 F-box-like ANAPC4_WD40 PF12894.7 EXF80353.1 - 8.4e-09 35.6 1.7 0.18 12.1 0.0 5.6 1 1 5 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EXF80353.1 - 2e-06 26.8 7.4 0.19 10.4 0.1 5.8 2 2 4 6 6 6 3 Nucleoporin Nup120/160 F-box PF00646.33 EXF80353.1 - 7.6e-06 25.7 2.5 1.5e-05 24.7 2.5 1.5 1 0 0 1 1 1 1 F-box domain WD40_like PF17005.5 EXF80353.1 - 0.0026 17.2 0.0 0.081 12.2 0.0 2.4 2 1 0 2 2 2 1 WD40-like domain PQQ_3 PF13570.6 EXF80353.1 - 0.0071 16.8 1.0 16 6.1 0.0 4.7 5 0 0 5 5 5 1 PQQ-like domain PQQ_2 PF13360.6 EXF80353.1 - 0.093 12.3 3.7 0.53 9.8 1.1 3.1 1 1 1 2 2 2 0 PQQ-like domain PALB2_WD40 PF16756.5 EXF80353.1 - 0.12 11.2 3.2 8.9 5.1 0.0 3.4 3 1 1 4 4 4 0 Partner and localizer of BRCA2 WD40 domain E1_dh PF00676.20 EXF80354.1 - 3.4e-111 371.0 0.3 4.2e-111 370.7 0.3 1.0 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.6 EXF80354.1 - 0.0025 17.1 0.6 0.0037 16.5 0.1 1.5 2 0 0 2 2 2 1 1-deoxy-D-xylulose-5-phosphate synthase DNA_ligase_A_M PF01068.21 EXF80355.1 - 3.5e-59 199.9 0.9 5.2e-47 160.1 0.3 2.4 2 0 0 2 2 2 2 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 EXF80355.1 - 2.7e-43 148.3 0.0 5.6e-43 147.2 0.0 1.6 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.15 EXF80355.1 - 2.6e-28 98.5 0.0 1.3e-27 96.3 0.0 2.3 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region RNA_ligase PF09414.10 EXF80355.1 - 1.2e-05 25.7 0.1 2e-05 24.9 0.1 1.4 1 0 0 1 1 1 1 RNA ligase SOG2 PF10428.9 EXF80355.1 - 0.03 13.6 10.3 0.046 12.9 10.3 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein Hydrolase_4 PF12146.8 EXF80356.1 - 0.01 15.2 0.0 0.017 14.4 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EXF80356.1 - 0.021 15.5 0.0 0.08 13.5 0.0 1.9 2 0 0 2 2 2 0 Alpha/beta hydrolase family LCAT PF02450.15 EXF80356.1 - 0.038 13.2 0.0 0.055 12.6 0.0 1.2 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase Palm_thioest PF02089.15 EXF80356.1 - 0.15 11.8 0.0 0.25 11.2 0.0 1.2 1 0 0 1 1 1 0 Palmitoyl protein thioesterase DUF810 PF05664.11 EXF80357.1 - 0.0026 16.4 0.3 0.0032 16.1 0.3 1.0 1 0 0 1 1 1 1 Plant family of unknown function (DUF810) His_Phos_2 PF00328.22 EXF80358.1 - 6.5e-16 58.7 0.0 1.3e-11 44.5 0.0 2.9 2 1 0 2 2 2 2 Histidine phosphatase superfamily (branch 2) Collagen PF01391.18 EXF80359.1 - 8.6 6.2 18.6 3.1 7.6 6.6 4.6 4 1 0 4 4 4 0 Collagen triple helix repeat (20 copies) PI-PLC-X PF00388.19 EXF80360.1 - 3.7e-63 211.5 0.0 5.4e-63 210.9 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 EXF80360.1 - 2e-42 144.1 0.0 3.8e-42 143.3 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain EF-hand_like PF09279.11 EXF80360.1 - 0.043 14.3 0.0 0.088 13.3 0.0 1.5 1 0 0 1 1 1 0 Phosphoinositide-specific phospholipase C, efhand-like CorA PF01544.18 EXF80361.1 - 0.00061 19.2 1.6 0.001 18.5 0.9 1.7 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein EMP70 PF02990.16 EXF80361.1 - 0.027 13.2 0.0 0.041 12.6 0.0 1.2 1 0 0 1 1 1 0 Endomembrane protein 70 PAP_PilO PF06864.12 EXF80361.1 - 0.095 11.5 0.1 0.17 10.7 0.1 1.4 1 0 0 1 1 1 0 Pilin accessory protein (PilO) COX16 PF14138.6 EXF80361.1 - 0.1 13.1 0.1 2.4 8.7 0.0 2.9 2 1 0 2 2 2 0 Cytochrome c oxidase assembly protein COX16 Lectin_leg-like PF03388.13 EXF80362.1 - 3.6e-65 219.5 0.0 4.7e-65 219.1 0.0 1.1 1 0 0 1 1 1 1 Legume-like lectin family Lectin_legB PF00139.19 EXF80362.1 - 2.6e-05 23.9 0.0 0.0013 18.3 0.0 2.1 1 1 0 1 1 1 1 Legume lectin domain zf-Tim10_DDP PF02953.15 EXF80363.1 - 5e-23 80.5 1.6 6.4e-23 80.2 1.6 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger DUF2040 PF09745.9 EXF80364.1 - 1e-38 132.1 25.2 1e-38 132.1 25.2 3.7 2 2 1 3 3 3 1 Coiled-coil domain-containing protein 55 (DUF2040) DUF2315 PF10231.9 EXF80364.1 - 6.5 6.9 11.4 0.14 12.2 3.6 2.2 2 0 0 2 2 2 0 Apoptogenic protein 1 LMBR1 PF04791.16 EXF80365.1 - 1.2e-108 364.2 6.3 1.4e-108 364.0 6.3 1.0 1 0 0 1 1 1 1 LMBR1-like membrane protein CAF1 PF04857.20 EXF80366.1 - 1.6e-22 80.1 0.1 1.6e-10 40.7 0.0 2.1 2 0 0 2 2 2 2 CAF1 family ribonuclease RFX_DNA_binding PF02257.15 EXF80366.1 - 0.17 12.6 0.0 0.53 11.0 0.0 1.8 2 0 0 2 2 2 0 RFX DNA-binding domain NDUF_B12 PF08122.12 EXF80367.1 - 1.3e-24 86.0 0.7 1.8e-24 85.5 0.7 1.2 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B12 subunit family Spc7 PF08317.11 EXF80368.1 - 0.0042 16.0 11.2 0.0081 15.1 11.2 1.4 1 0 0 1 1 1 1 Spc7 kinetochore protein Golgin_A5 PF09787.9 EXF80368.1 - 0.047 13.2 12.4 0.071 12.6 12.4 1.2 1 0 0 1 1 1 0 Golgin subfamily A member 5 MAD PF05557.13 EXF80368.1 - 0.056 11.8 13.0 0.37 9.1 11.8 2.0 2 0 0 2 2 2 0 Mitotic checkpoint protein Atg14 PF10186.9 EXF80368.1 - 0.067 12.3 4.3 0.12 11.4 4.3 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Cwf_Cwc_15 PF04889.12 EXF80368.1 - 0.071 12.8 10.0 0.11 12.2 10.0 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein UPF0565 PF10561.9 EXF80368.1 - 0.29 10.3 1.2 0.47 9.6 1.2 1.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0565 CLZ PF16526.5 EXF80368.1 - 0.47 10.9 7.8 2.9 8.3 5.9 2.5 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF2730 PF10805.8 EXF80368.1 - 0.55 10.3 4.3 1.1 9.4 2.1 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2730) Fib_alpha PF08702.10 EXF80368.1 - 0.79 9.9 6.9 0.56 10.4 4.8 1.8 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family FlaC_arch PF05377.11 EXF80368.1 - 1.1 9.7 3.6 49 4.4 0.0 2.4 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) Seryl_tRNA_N PF02403.22 EXF80368.1 - 1.4 9.2 10.9 1.9 8.8 7.3 2.4 2 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain ZapB PF06005.12 EXF80368.1 - 2 8.9 0.0 2 8.9 0.0 2.8 2 1 0 2 2 2 0 Cell division protein ZapB eIF-6 PF01912.18 EXF80369.1 - 1.8e-81 272.3 0.3 2.4e-81 271.8 0.3 1.2 1 0 0 1 1 1 1 eIF-6 family NRDE-2 PF08424.10 EXF80370.1 - 5.3e-98 328.1 0.2 5.3e-98 328.1 0.2 3.2 4 0 0 4 4 4 1 NRDE-2, necessary for RNA interference TPR_17 PF13431.6 EXF80370.1 - 0.095 13.1 0.1 2.5 8.7 0.3 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 EXF80370.1 - 0.91 10.5 13.5 13 7.0 0.0 6.6 7 1 1 8 8 8 0 Tetratricopeptide repeat Voltage_CLC PF00654.20 EXF80371.1 - 1.4e-90 304.1 27.9 2.1e-90 303.5 24.9 2.1 2 0 0 2 2 2 2 Voltage gated chloride channel Aminotran_3 PF00202.21 EXF80372.1 - 6.1e-121 403.9 0.0 7e-121 403.7 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 EXF80372.1 - 0.13 11.4 0.0 0.2 10.8 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class I and II SRI PF08236.11 EXF80374.1 - 2.5e-22 78.9 5.9 8.1e-22 77.2 5.9 2.0 1 0 0 1 1 1 1 SRI (Set2 Rpb1 interacting) domain SET PF00856.28 EXF80374.1 - 1.5e-17 64.5 0.3 1.5e-17 64.5 0.3 3.2 2 2 0 2 2 2 1 SET domain AWS PF17907.1 EXF80374.1 - 8.5e-11 41.7 6.9 8.5e-11 41.7 6.9 2.3 2 0 0 2 2 2 1 AWS domain Med26 PF08711.11 EXF80374.1 - 2.2e-05 24.4 2.2 2.8e-05 24.0 0.4 2.2 2 0 0 2 2 2 1 TFIIS helical bundle-like domain WW PF00397.26 EXF80374.1 - 0.025 14.6 0.3 0.066 13.3 0.3 1.8 1 0 0 1 1 1 0 WW domain SNN_linker PF09050.10 EXF80374.1 - 0.11 12.3 2.0 0.24 11.2 0.5 2.3 2 0 0 2 2 2 0 Stannin unstructured linker DUF2431 PF10354.9 EXF80375.1 - 2.7e-60 203.5 0.0 8.2e-60 201.9 0.0 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF2431) MA3 PF02847.17 EXF80376.1 - 0.18 11.8 0.0 0.42 10.6 0.0 1.5 1 0 0 1 1 1 0 MA3 domain ThiF PF00899.21 EXF80377.1 - 3e-29 102.1 0.0 4.1e-29 101.6 0.0 1.1 1 0 0 1 1 1 1 ThiF family Rrn6 PF10214.9 EXF80377.1 - 1.4 7.3 0.0 1.4 7.3 0.0 2.0 1 1 1 2 2 2 0 RNA polymerase I-specific transcription-initiation factor DHFR_1 PF00186.19 EXF80379.1 - 6.1e-29 100.8 0.0 2.7e-28 98.7 0.0 1.9 2 1 0 2 2 2 1 Dihydrofolate reductase ketoacyl-synt PF00109.26 EXF80380.1 - 2.4e-62 210.8 0.2 2.4e-62 210.8 0.2 2.1 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 EXF80380.1 - 2.1e-35 121.3 2.6 2.3e-35 121.1 1.5 1.6 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.23 EXF80380.1 - 5.6e-06 25.9 0.5 1.6e-05 24.4 0.1 1.8 2 0 0 2 2 2 1 Thiolase, N-terminal domain KAsynt_C_assoc PF16197.5 EXF80380.1 - 0.062 13.8 0.3 0.12 12.8 0.3 1.5 1 0 0 1 1 1 0 Ketoacyl-synthetase C-terminal extension OPT PF03169.15 EXF80381.1 - 8e-180 599.5 51.8 9.2e-180 599.3 51.8 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein DUF4191 PF13829.6 EXF80381.1 - 1 8.6 3.7 0.33 10.2 0.3 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4191) DUF3295 PF11702.8 EXF80382.1 - 6e-167 557.0 30.3 7.2e-167 556.7 30.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3295) DUF1752 PF08550.10 EXF80382.1 - 1.2e-12 47.4 2.0 2.5e-12 46.4 2.0 1.6 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) VHS PF00790.19 EXF80384.1 - 3.2e-18 66.0 0.0 6.2e-18 65.0 0.0 1.5 1 0 0 1 1 1 1 VHS domain GAT PF03127.14 EXF80384.1 - 7.6e-08 32.6 1.0 2.2e-07 31.1 1.0 1.8 1 0 0 1 1 1 1 GAT domain ORC5_C PF14630.6 EXF80384.1 - 0.079 12.5 6.2 0.09 12.3 5.7 1.4 1 1 0 1 1 1 0 Origin recognition complex (ORC) subunit 5 C-terminus YliH PF10799.8 EXF80384.1 - 0.11 12.4 1.2 0.34 10.8 0.1 2.2 2 1 0 2 2 2 0 Biofilm formation protein (YliH/bssR) Ribosomal_60s PF00428.19 EXF80384.1 - 0.14 12.7 0.4 0.14 12.7 0.4 2.9 3 0 0 3 3 3 0 60s Acidic ribosomal protein SR-25 PF10500.9 EXF80384.1 - 0.37 10.4 12.4 0.61 9.7 12.4 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Pox_A_type_inc PF04508.12 EXF80384.1 - 5.5 7.0 5.9 2.5 8.1 1.9 2.5 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat DUF2461 PF09365.10 EXF80386.1 - 8e-84 280.8 0.2 1.1e-83 280.2 0.2 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein (DUF2461) Merozoite_SPAM PF07133.11 EXF80386.1 - 1.2 9.1 32.6 0.36 10.8 5.0 3.3 3 0 0 3 3 3 0 Merozoite surface protein (SPAM) NmrA PF05368.13 EXF80387.1 - 2e-17 63.5 0.0 2.4e-17 63.3 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EXF80387.1 - 5.1e-12 46.1 0.2 2.1e-11 44.1 0.2 2.0 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EXF80387.1 - 7.1e-08 32.2 0.5 8.8e-05 22.1 0.1 2.2 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family KR PF08659.10 EXF80387.1 - 0.051 13.5 0.2 0.11 12.4 0.2 1.5 2 0 0 2 2 2 0 KR domain Polysacc_synt_2 PF02719.15 EXF80387.1 - 0.12 11.5 0.3 0.24 10.5 0.3 1.5 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein DapB_N PF01113.20 EXF80387.1 - 0.19 11.8 1.1 2.4 8.3 0.4 2.1 1 1 1 2 2 2 0 Dihydrodipicolinate reductase, N-terminus CbiA PF01656.23 EXF80387.1 - 0.3 11.2 1.0 2 8.5 1.4 2.0 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain Fungal_trans PF04082.18 EXF80389.1 - 1.5e-08 34.0 0.1 4.9e-08 32.3 0.1 1.7 1 1 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 EXF80389.1 - 0.0054 17.1 3.6 0.0054 17.1 3.6 2.5 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EXF80389.1 - 0.011 16.2 13.2 0.02 15.3 1.6 3.4 3 0 0 3 3 3 0 Zinc-finger double domain zf-C2H2_4 PF13894.6 EXF80389.1 - 0.012 16.4 2.9 0.012 16.4 2.9 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger Methyltransf_16 PF10294.9 EXF80390.1 - 5.3e-12 45.8 0.0 1.4e-10 41.2 0.0 2.0 1 1 0 1 1 1 1 Lysine methyltransferase PrmA PF06325.13 EXF80390.1 - 0.019 14.4 0.0 0.025 14.0 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) GidB PF02527.15 EXF80390.1 - 0.099 12.0 0.0 0.18 11.1 0.0 1.4 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G DNA_pol_phi PF04931.13 EXF80391.1 - 0.17 10.0 16.8 0.27 9.3 16.8 1.2 1 0 0 1 1 1 0 DNA polymerase phi Copper-fist PF00649.18 EXF80392.1 - 8.8e-19 66.7 0.7 1.7e-18 65.8 0.7 1.5 1 0 0 1 1 1 1 Copper fist DNA binding domain Surp PF01805.20 EXF80393.1 - 4.6e-10 39.3 0.0 9.3e-10 38.4 0.0 1.6 1 0 0 1 1 1 1 Surp module EF-hand_1 PF00036.32 EXF80395.1 - 7.1e-30 100.3 9.6 1.4e-09 36.8 2.1 3.1 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.6 EXF80395.1 - 4e-26 91.3 1.6 1e-17 64.3 0.4 2.0 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 EXF80395.1 - 3.6e-25 87.6 6.9 4.3e-11 42.5 0.5 3.0 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 EXF80395.1 - 4.5e-22 76.0 4.5 6e-09 35.1 0.0 3.2 3 0 0 3 3 3 3 EF-hand domain EF-hand_5 PF13202.6 EXF80395.1 - 1.4e-19 68.7 7.8 2.3e-07 30.0 0.0 3.3 3 0 0 3 3 3 3 EF hand EF-hand_9 PF14658.6 EXF80395.1 - 6.3e-12 45.6 0.2 1.8e-06 28.2 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 EXF80395.1 - 2.8e-07 30.4 2.0 0.00075 19.4 0.1 2.1 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 EXF80395.1 - 8.9e-05 22.8 0.1 0.013 15.8 0.0 2.0 1 1 1 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EFhand_Ca_insen PF08726.10 EXF80395.1 - 0.001 19.1 0.1 0.0072 16.4 0.0 2.0 2 0 0 2 2 2 1 Ca2+ insensitive EF hand TerB PF05099.13 EXF80395.1 - 0.0078 16.2 0.4 1.5 8.8 0.0 2.0 1 1 1 2 2 2 2 Tellurite resistance protein TerB EF-hand_11 PF08976.11 EXF80395.1 - 0.0091 16.9 0.0 0.2 12.6 0.0 2.0 1 1 1 2 2 2 1 EF-hand domain Caleosin PF05042.13 EXF80395.1 - 0.04 13.8 0.4 3 7.7 0.0 2.5 1 1 2 3 3 3 0 Caleosin related protein AAA_assoc_C PF09821.9 EXF80395.1 - 0.047 14.2 0.1 1.7 9.2 0.0 2.2 1 1 0 2 2 2 0 C-terminal AAA-associated domain UPF0154 PF03672.13 EXF80395.1 - 0.1 12.6 0.0 17 5.5 0.0 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0154) Poly_export PF02563.16 EXF80395.1 - 0.17 12.2 0.0 0.62 10.3 0.0 2.0 1 1 1 2 2 2 0 Polysaccharide biosynthesis/export protein DAO PF01266.24 EXF80396.1 - 2.8e-42 145.6 0.3 3.3e-42 145.3 0.3 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EXF80396.1 - 1.5e-06 28.3 0.0 3.7e-06 27.1 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 EXF80396.1 - 2.6e-06 27.5 0.2 0.024 14.6 0.0 2.4 2 0 0 2 2 2 2 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 EXF80396.1 - 1.3e-05 24.6 0.0 0.061 12.5 0.0 2.5 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Ribosomal_S25 PF03297.15 EXF80396.1 - 0.0025 18.0 0.3 0.005 17.0 0.3 1.5 1 0 0 1 1 1 1 S25 ribosomal protein Trp_halogenase PF04820.14 EXF80396.1 - 0.0055 15.6 0.0 0.54 9.0 0.0 2.1 2 0 0 2 2 2 1 Tryptophan halogenase Thi4 PF01946.17 EXF80396.1 - 0.0061 15.8 0.2 0.019 14.2 0.0 1.9 2 0 0 2 2 2 1 Thi4 family GIDA PF01134.22 EXF80396.1 - 0.011 14.9 0.0 0.04 13.0 0.0 1.8 2 0 0 2 2 2 0 Glucose inhibited division protein A FAD_binding_2 PF00890.24 EXF80396.1 - 0.011 14.8 0.0 1.1 8.3 0.0 2.3 2 0 0 2 2 2 0 FAD binding domain Glu_dehyd_C PF16912.5 EXF80396.1 - 0.014 14.9 0.0 0.033 13.7 0.0 1.6 1 0 0 1 1 1 0 Glucose dehydrogenase C-terminus Sacchrp_dh_NADP PF03435.18 EXF80396.1 - 0.015 15.6 0.0 0.036 14.3 0.0 1.7 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain K_oxygenase PF13434.6 EXF80396.1 - 0.041 13.0 0.0 0.1 11.8 0.0 1.6 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox PF00070.27 EXF80396.1 - 0.081 13.5 0.0 0.19 12.3 0.0 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase MCRA PF06100.11 EXF80396.1 - 0.11 11.2 0.0 0.19 10.5 0.0 1.3 1 0 0 1 1 1 0 MCRA family SR-25 PF10500.9 EXF80396.1 - 1.7 8.2 5.8 2.6 7.6 5.8 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein TBP PF00352.21 EXF80397.1 - 1.5e-67 223.6 0.1 7.1e-33 112.4 0.0 2.1 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.8 EXF80397.1 - 0.00012 22.1 0.0 0.22 11.6 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF3378) Lpp-LpqN PF10738.9 EXF80397.1 - 0.034 13.6 0.1 0.054 13.0 0.1 1.2 1 0 0 1 1 1 0 Probable lipoprotein LpqN DUF4295 PF14128.6 EXF80397.1 - 0.13 12.1 0.1 0.68 9.8 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4295) ETF_QO PF05187.13 EXF80398.1 - 7.4e-49 164.2 0.6 1.3e-48 163.4 0.6 1.4 1 0 0 1 1 1 1 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S DAO PF01266.24 EXF80398.1 - 3.2e-10 40.1 0.2 0.00014 21.6 0.4 2.4 1 1 1 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EXF80398.1 - 1.4e-07 31.6 0.0 7.7e-07 29.2 0.0 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EXF80398.1 - 4.1e-06 26.1 0.4 0.00035 19.8 0.9 2.2 1 1 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.14 EXF80398.1 - 6.4e-06 25.6 0.1 5e-05 22.7 0.1 2.4 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EXF80398.1 - 9.4e-05 21.3 0.5 0.00014 20.8 0.5 1.2 1 0 0 1 1 1 1 HI0933-like protein Thi4 PF01946.17 EXF80398.1 - 0.00011 21.5 0.0 0.00041 19.7 0.1 1.7 2 0 0 2 2 2 1 Thi4 family Pyr_redox PF00070.27 EXF80398.1 - 0.00019 21.9 0.1 0.88 10.2 0.2 3.2 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EXF80398.1 - 0.00083 18.3 0.3 0.063 12.1 0.2 2.4 3 0 0 3 3 3 1 Tryptophan halogenase FAD_oxidored PF12831.7 EXF80398.1 - 0.001 18.5 0.1 0.0018 17.7 0.0 1.5 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 EXF80398.1 - 0.0011 18.3 0.2 0.002 17.4 0.2 1.4 1 0 0 1 1 1 1 FAD binding domain NAD_binding_9 PF13454.6 EXF80398.1 - 0.0019 18.2 0.2 0.0049 16.9 0.2 1.6 2 0 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox_3 PF13738.6 EXF80398.1 - 0.0048 16.2 0.2 0.0075 15.6 0.2 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EXF80398.1 - 0.01 14.9 0.2 0.016 14.3 0.2 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein AlaDh_PNT_C PF01262.21 EXF80398.1 - 0.012 14.9 0.0 0.021 14.1 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Fer4_7 PF12838.7 EXF80398.1 - 0.036 14.6 0.9 0.097 13.3 0.9 1.7 1 0 0 1 1 1 0 4Fe-4S dicluster domain GIDA PF01134.22 EXF80398.1 - 0.06 12.4 0.1 0.09 11.8 0.1 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A Fer4_2 PF12797.7 EXF80398.1 - 0.18 12.0 0.7 0.46 10.7 0.7 1.6 1 0 0 1 1 1 0 4Fe-4S binding domain Glyco_hydro_92 PF07971.12 EXF80399.1 - 9.1e-147 489.7 0.2 1.1e-146 489.4 0.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 Glyco_hydro_92N PF17678.1 EXF80399.1 - 2.8e-68 230.4 0.3 4.3e-68 229.8 0.3 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 N-terminal domain Glyco_hydro_125 PF06824.11 EXF80400.1 - 1.9e-171 570.5 0.0 2.3e-171 570.3 0.0 1.0 1 0 0 1 1 1 1 Metal-independent alpha-mannosidase (GH125) HECT PF00632.25 EXF80401.1 - 1.7e-82 277.3 0.0 3.3e-82 276.4 0.0 1.5 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) IQ PF00612.27 EXF80401.1 - 0.02 14.6 4.0 0.055 13.3 4.0 1.7 1 0 0 1 1 1 0 IQ calmodulin-binding motif RRM_1 PF00076.22 EXF80402.1 - 2e-83 274.2 7.5 1.5e-21 76.0 0.2 5.4 5 0 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.18 EXF80402.1 - 3.4e-26 91.2 0.8 1.6e-25 89.1 0.8 2.1 2 0 0 2 2 2 1 Poly-adenylate binding protein, unique domain RRM_5 PF13893.6 EXF80402.1 - 3.3e-09 36.4 0.0 0.019 14.6 0.0 5.0 2 1 2 5 5 5 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EXF80402.1 - 1.9e-05 24.5 0.1 0.0082 16.0 0.0 3.5 4 0 0 4 4 4 1 Occluded RNA-recognition motif RRM_7 PF16367.5 EXF80402.1 - 6.9e-05 22.9 0.3 0.84 9.8 0.0 5.1 5 0 0 5 5 5 1 RNA recognition motif Nup35_RRM_2 PF14605.6 EXF80402.1 - 0.00043 20.2 1.6 13 5.9 0.1 4.9 4 1 0 4 4 4 0 Nup53/35/40-type RNA recognition motif CbiG_mid PF11761.8 EXF80402.1 - 0.001 19.1 0.0 14 5.8 0.0 3.8 3 0 0 3 3 3 0 Cobalamin biosynthesis central region YflT PF11181.8 EXF80402.1 - 0.031 14.8 6.2 0.27 11.8 0.5 3.4 3 0 0 3 3 3 0 Heat induced stress protein YflT OB_RNB PF08206.11 EXF80402.1 - 0.045 13.4 1.8 9 6.1 0.0 3.5 3 0 0 3 3 3 0 Ribonuclease B OB domain YqfQ PF14181.6 EXF80402.1 - 0.087 13.0 9.9 0.42 10.8 9.9 2.2 1 0 0 1 1 1 0 YqfQ-like protein NPR3 PF03666.13 EXF80402.1 - 0.44 9.3 6.8 0.71 8.6 6.8 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 PhetRS_B1 PF18262.1 EXF80402.1 - 0.5 10.6 3.7 30 4.9 0.0 3.4 3 1 0 3 3 3 0 Phe-tRNA synthetase beta subunit B1 domain CDC45 PF02724.14 EXF80402.1 - 1.1 7.5 13.4 1.6 6.9 13.4 1.2 1 0 0 1 1 1 0 CDC45-like protein DHHA1 PF02272.19 EXF80402.1 - 2.8 8.4 10.1 5.6 7.4 0.2 3.1 3 0 0 3 3 2 0 DHHA1 domain DNA_pol_phi PF04931.13 EXF80402.1 - 4 5.4 13.3 6.2 4.8 13.3 1.2 1 0 0 1 1 1 0 DNA polymerase phi Presenilin PF01080.17 EXF80402.1 - 8 5.1 8.3 12 4.6 8.3 1.2 1 0 0 1 1 1 0 Presenilin Thiolase_N PF00108.23 EXF80403.1 - 2.2e-75 253.4 3.7 3e-75 252.9 3.7 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EXF80403.1 - 9.4e-41 138.3 0.2 2e-40 137.3 0.2 1.5 1 0 0 1 1 1 1 Thiolase, C-terminal domain ACP_syn_III_C PF08541.10 EXF80403.1 - 0.012 15.8 0.0 0.056 13.6 0.0 2.2 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal ketoacyl-synt PF00109.26 EXF80403.1 - 0.16 11.5 3.4 0.075 12.6 0.5 1.9 2 1 0 2 2 2 0 Beta-ketoacyl synthase, N-terminal domain NMO PF03060.15 EXF80404.1 - 4.9e-55 187.2 0.6 7.1e-54 183.4 0.6 1.9 1 1 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.25 EXF80404.1 - 4.3e-14 52.3 0.0 1.9e-11 43.6 0.0 2.1 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.18 EXF80404.1 - 0.0003 20.0 0.3 0.00051 19.2 0.3 1.4 1 0 0 1 1 1 1 FMN-dependent dehydrogenase His_biosynth PF00977.21 EXF80404.1 - 0.11 12.0 0.3 0.27 10.7 0.1 1.8 2 0 0 2 2 2 0 Histidine biosynthesis protein VASP_tetra PF08776.11 EXF80404.1 - 2.5 7.7 5.6 8.6 6.0 0.7 2.5 2 0 0 2 2 2 0 VASP tetramerisation domain Bul1_C PF04426.12 EXF80405.1 - 9.2e-05 22.0 0.0 0.00016 21.2 0.0 1.4 1 0 0 1 1 1 1 Bul1 C terminus Arrestin_N PF00339.29 EXF80405.1 - 0.00019 21.5 0.0 0.0011 19.0 0.0 2.2 1 1 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Bul1_N PF04425.12 EXF80405.1 - 0.001 17.9 0.8 0.03 13.1 0.0 2.8 1 1 2 3 3 3 1 Bul1 N terminus Zip PF02535.22 EXF80407.1 - 1.6e-56 192.0 6.7 8.4e-56 189.6 6.7 1.8 1 1 0 1 1 1 1 ZIP Zinc transporter Senescence PF06911.12 EXF80410.1 - 4.4e-55 186.8 4.3 6.7e-55 186.2 4.3 1.3 1 0 0 1 1 1 1 Senescence-associated protein GCP_N_terminal PF17681.1 EXF80411.1 - 5.4e-29 101.8 0.0 7.9e-29 101.3 0.0 1.2 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 EXF80411.1 - 8.4e-25 87.9 0.0 1.6e-24 87.0 0.0 1.4 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal adh_short_C2 PF13561.6 EXF80413.1 - 3.7e-63 213.2 0.7 5.1e-63 212.8 0.7 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF80413.1 - 1.7e-51 174.5 0.6 2.5e-51 173.9 0.6 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EXF80413.1 - 5.9e-11 42.6 0.2 8.1e-11 42.1 0.2 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EXF80413.1 - 8.3e-05 22.2 0.2 0.00019 21.0 0.2 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family PA PF02225.22 EXF80413.1 - 0.0025 17.8 0.2 0.0078 16.2 0.1 1.9 2 0 0 2 2 2 1 PA domain GDP_Man_Dehyd PF16363.5 EXF80413.1 - 0.017 14.6 0.1 0.027 13.9 0.1 1.4 1 1 0 1 1 1 0 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 EXF80413.1 - 0.019 14.1 0.0 0.028 13.5 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein ARID PF01388.21 EXF80414.1 - 2e-17 63.6 0.4 5.4e-17 62.2 0.1 2.0 2 0 0 2 2 2 1 ARID/BRIGHT DNA binding domain Trns_repr_metal PF02583.17 EXF80414.1 - 0.82 10.1 3.0 0.78 10.2 0.1 2.5 3 0 0 3 3 3 0 Metal-sensitive transcriptional repressor HECT PF00632.25 EXF80417.1 - 3.9e-64 217.1 0.0 5.5e-64 216.6 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) AZUL PF16558.5 EXF80417.1 - 8.4e-22 77.2 2.7 2.1e-21 75.9 2.7 1.7 1 0 0 1 1 1 1 Amino-terminal Zinc-binding domain of ubiquitin ligase E3A Matrilin_ccoil PF10393.9 EXF80417.1 - 0.16 11.9 0.1 5.1 7.0 0.0 2.4 2 0 0 2 2 2 0 Trimeric coiled-coil oligomerisation domain of matrilin zf-C2H2_2 PF12756.7 EXF80418.1 - 1.1e-35 122.0 12.8 6.9e-30 103.4 4.3 3.6 3 0 0 3 3 3 3 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.8 EXF80418.1 - 7e-08 32.6 6.3 1.4e-07 31.6 3.9 4.1 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EXF80418.1 - 1.3e-06 28.6 3.2 1.3e-06 28.6 3.2 2.7 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 EXF80418.1 - 0.00043 20.9 17.2 0.22 12.4 0.2 5.2 5 0 0 5 5 5 2 C2H2-type zinc finger SnoaL_2 PF12680.7 EXF80418.1 - 0.012 16.2 2.3 0.13 12.9 2.1 2.4 2 0 0 2 2 2 0 SnoaL-like domain IQCJ-SCHIP1 PF15157.6 EXF80418.1 - 0.094 12.6 0.2 0.22 11.3 0.2 1.6 1 0 0 1 1 1 0 Fusion protein IQCJ-SCHIP1 with IQ-like motif zf-C2H2 PF00096.26 EXF80418.1 - 0.2 12.2 20.8 4.3 8.0 0.3 4.9 4 0 0 4 4 4 0 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 EXF80418.1 - 0.31 11.1 5.6 10 6.2 0.1 3.2 2 0 0 2 2 2 0 C2H2-type zinc finger MMR_HSR1 PF01926.23 EXF80419.1 - 1.7e-18 66.8 0.0 2.7e-18 66.1 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 EXF80419.1 - 2.3e-08 34.3 0.0 0.00071 19.7 0.1 2.4 2 0 0 2 2 2 2 Dynamin family FeoB_N PF02421.18 EXF80419.1 - 5.3e-06 26.1 0.0 0.00015 21.4 0.1 2.1 2 0 0 2 2 2 1 Ferrous iron transport protein B GTP_EFTU PF00009.27 EXF80419.1 - 9.2e-06 25.3 0.0 3.2e-05 23.6 0.0 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain IIGP PF05049.13 EXF80419.1 - 3.1e-05 23.2 0.0 0.05 12.6 0.0 2.1 2 0 0 2 2 2 2 Interferon-inducible GTPase (IIGP) RsgA_GTPase PF03193.16 EXF80419.1 - 0.0079 16.1 0.8 0.17 11.8 0.4 2.6 2 1 0 2 2 2 1 RsgA GTPase Septin PF00735.18 EXF80419.1 - 0.024 13.9 0.0 0.094 12.0 0.0 1.8 1 1 0 1 1 1 0 Septin SRPRB PF09439.10 EXF80419.1 - 0.026 14.0 0.0 7.6 5.9 0.0 2.3 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit AIG1 PF04548.16 EXF80419.1 - 0.051 12.9 0.0 9.2 5.5 0.0 2.3 2 0 0 2 2 2 0 AIG1 family AAA_21 PF13304.6 EXF80419.1 - 0.074 12.8 0.3 0.22 11.3 0.0 1.9 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system ABC_tran PF00005.27 EXF80419.1 - 0.11 12.9 0.0 2.7 8.5 0.1 2.5 2 1 0 2 2 2 0 ABC transporter TniB PF05621.11 EXF80419.1 - 0.16 11.3 0.1 0.93 8.9 0.0 2.0 2 0 0 2 2 2 0 Bacterial TniB protein AAA_15 PF13175.6 EXF80419.1 - 0.24 11.1 0.0 0.4 10.3 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain zf-C3HC PF07967.13 EXF80420.1 - 1.9e-39 134.7 1.5 3e-35 121.1 0.5 2.6 3 0 0 3 3 3 2 C3HC zinc finger-like Rsm1 PF08600.10 EXF80420.1 - 1.3e-27 95.8 0.9 4e-26 91.0 0.0 2.6 2 1 0 2 2 2 1 Rsm1-like BIR PF00653.21 EXF80420.1 - 0.00019 22.0 0.1 0.0062 17.2 0.1 2.5 2 0 0 2 2 2 1 Inhibitor of Apoptosis domain SRP40_C PF05022.12 EXF80421.1 - 1.6e-22 80.1 0.2 1.6e-22 80.1 0.2 2.8 3 0 0 3 3 3 1 SRP40, C-terminal domain A_deaminase PF00962.22 EXF80422.1 - 5.4e-26 91.7 0.0 1.3e-24 87.1 0.0 2.2 1 1 0 1 1 1 1 Adenosine/AMP deaminase A_deaminase_N PF08451.11 EXF80422.1 - 1.5e-05 25.2 2.6 2.6e-05 24.4 0.8 2.3 2 1 0 2 2 2 1 Adenosine/AMP deaminase N-terminal DUF3490 PF11995.8 EXF80422.1 - 0.048 13.5 0.1 0.13 12.1 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3490) Cupin_2 PF07883.11 EXF80423.1 - 2.3e-10 40.0 0.5 2.1e-05 24.2 0.0 3.1 3 0 0 3 3 3 2 Cupin domain Cupin_1 PF00190.22 EXF80423.1 - 6.2e-06 25.9 0.4 0.0054 16.4 0.0 2.9 3 0 0 3 3 3 2 Cupin Cupin_3 PF05899.12 EXF80423.1 - 0.00027 20.6 0.0 0.038 13.7 0.0 2.6 2 0 0 2 2 2 1 Protein of unknown function (DUF861) Cupin_6 PF12852.7 EXF80423.1 - 0.003 17.3 0.0 0.68 9.6 0.0 2.4 2 0 0 2 2 2 2 Cupin ARD PF03079.14 EXF80423.1 - 0.18 12.0 0.0 15 5.8 0.0 2.2 2 0 0 2 2 2 0 ARD/ARD' family Histone_H2A_C PF16211.5 EXF80423.1 - 0.22 11.3 1.0 0.36 10.6 0.0 1.9 2 0 0 2 2 2 0 C-terminus of histone H2A GMC_oxred_N PF00732.19 EXF80424.1 - 1.4e-51 175.7 0.0 1.7e-51 175.3 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EXF80424.1 - 4.5e-31 108.3 0.0 9.1e-31 107.3 0.0 1.6 1 0 0 1 1 1 1 GMC oxidoreductase DAO PF01266.24 EXF80424.1 - 3.6e-07 30.1 0.0 5.7e-07 29.4 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EXF80424.1 - 0.001 18.4 0.0 0.013 14.8 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EXF80424.1 - 0.0017 17.6 0.3 0.035 13.2 0.0 2.4 2 0 0 2 2 2 1 FAD binding domain NAD_binding_8 PF13450.6 EXF80424.1 - 0.0019 18.4 0.4 0.0068 16.6 0.4 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 EXF80424.1 - 0.0035 16.6 0.0 0.0072 15.6 0.0 1.4 1 0 0 1 1 1 1 Thi4 family Pyr_redox_2 PF07992.14 EXF80424.1 - 0.0042 16.3 0.1 0.12 11.6 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.18 EXF80424.1 - 0.01 16.1 0.5 0.069 13.4 0.1 2.3 2 0 0 2 2 2 0 TrkA-N domain NAD_binding_9 PF13454.6 EXF80424.1 - 0.013 15.5 0.2 0.036 14.0 0.0 1.8 2 0 0 2 2 2 0 FAD-NAD(P)-binding HI0933_like PF03486.14 EXF80424.1 - 0.013 14.2 0.1 0.63 8.7 0.0 2.1 2 0 0 2 2 2 0 HI0933-like protein Arabinose_bd PF12625.7 EXF80424.1 - 0.053 13.6 0.1 0.11 12.6 0.1 1.5 1 0 0 1 1 1 0 Arabinose-binding domain of AraC transcription regulator, N-term FAD_binding_1 PF00667.20 EXF80425.1 - 3.9e-60 203.2 0.0 4.8e-59 199.6 0.0 2.3 2 0 0 2 2 2 1 FAD binding domain POR PF01558.18 EXF80425.1 - 6.4e-11 42.6 0.1 1.5e-10 41.4 0.1 1.5 1 0 0 1 1 1 1 Pyruvate ferredoxin/flavodoxin oxidoreductase NAD_binding_1 PF00175.21 EXF80425.1 - 1.1e-08 35.6 0.0 2.9e-08 34.3 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain PFOR_II PF17147.4 EXF80425.1 - 2.5e-07 30.9 0.0 7.8e-07 29.3 0.0 1.9 1 0 0 1 1 1 1 Pyruvate:ferredoxin oxidoreductase core domain II Transketolase_C PF02780.20 EXF80425.1 - 0.037 13.9 0.1 0.12 12.3 0.1 1.9 1 0 0 1 1 1 0 Transketolase, C-terminal domain E1-E2_ATPase PF00122.20 EXF80426.1 - 5.9e-47 159.5 0.6 5.9e-47 159.5 0.6 1.9 2 0 0 2 2 2 1 E1-E2 ATPase HMA PF00403.26 EXF80426.1 - 1e-35 122.0 2.7 3.9e-12 46.4 0.2 4.8 4 0 0 4 4 4 4 Heavy-metal-associated domain Hydrolase PF00702.26 EXF80426.1 - 4.9e-35 121.7 1.1 1.8e-34 119.9 1.1 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 EXF80426.1 - 2.4e-07 31.3 0.0 5.3e-07 30.2 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EXF80426.1 - 4.3e-06 26.6 0.2 0.00016 21.5 0.3 2.4 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Poly_export PF02563.16 EXF80426.1 - 0.1 12.8 0.0 5.8 7.2 0.0 2.7 2 0 0 2 2 2 0 Polysaccharide biosynthesis/export protein Pox_E10 PF04805.12 EXF80426.1 - 0.77 9.7 2.7 7.8 6.4 0.1 3.2 4 0 0 4 4 4 0 E10-like protein conserved region Pollen_Ole_e_I PF01190.17 EXF80426.1 - 1.8 9.0 6.9 26 5.3 0.1 3.6 4 0 0 4 4 4 0 Pollen proteins Ole e I like DUF3795 PF12675.7 EXF80426.1 - 2 8.9 4.8 68 4.0 0.8 4.0 4 1 1 5 5 5 0 Protein of unknown function (DUF3795) RseC_MucC PF04246.12 EXF80426.1 - 2.5 8.0 5.1 6.1 6.8 2.8 2.6 2 0 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC Cyclin_N PF00134.23 EXF80427.1 - 1.7e-13 50.5 0.0 3e-13 49.6 0.0 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 EXF80427.1 - 1.7e-07 31.7 0.1 5.4e-07 30.1 0.1 1.8 1 1 0 1 1 1 1 Cyclin MAP65_ASE1 PF03999.12 EXF80427.1 - 2.4 6.8 8.7 0.13 11.0 3.5 1.4 2 0 0 2 2 2 0 Microtubule associated protein (MAP65/ASE1 family) 4HBT PF03061.22 EXF80431.1 - 2.1e-11 44.0 0.0 3e-11 43.5 0.0 1.2 1 0 0 1 1 1 1 Thioesterase superfamily 4HBT_3 PF13622.6 EXF80431.1 - 6.1e-06 26.7 0.0 9.4e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 Thioesterase-like superfamily Pex2_Pex12 PF04757.14 EXF80432.1 - 6.7e-51 173.0 2.3 8.3e-51 172.7 2.3 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_4 PF15227.6 EXF80432.1 - 0.0021 18.1 3.6 0.0036 17.4 3.6 1.3 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.6 EXF80432.1 - 0.029 14.2 1.8 0.045 13.6 1.8 1.2 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EXF80432.1 - 0.029 14.7 3.5 0.048 14.0 3.5 1.3 1 0 0 1 1 1 0 Ring finger domain zf-C3HC4_2 PF13923.6 EXF80432.1 - 0.068 13.0 3.0 0.11 12.3 3.0 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EXF80432.1 - 0.2 11.6 2.4 0.33 10.8 2.4 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EXF80432.1 - 0.29 11.2 2.6 0.52 10.4 2.6 1.5 1 0 0 1 1 1 0 RING-type zinc-finger Glyco_hydro_16 PF00722.21 EXF80433.1 - 1.2e-06 28.2 0.0 3.8e-06 26.5 0.0 1.7 2 0 0 2 2 2 1 Glycosyl hydrolases family 16 Metallophos PF00149.28 EXF80434.1 - 4.9e-11 43.5 0.8 8.2e-11 42.8 0.8 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EXF80434.1 - 4.5e-05 23.7 0.6 0.00039 20.7 0.6 2.2 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Anoctamin PF04547.12 EXF80435.1 - 7.7e-117 390.9 10.6 9.4e-117 390.6 10.6 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel SH3_9 PF14604.6 EXF80436.1 - 6.9e-09 35.4 0.1 1.6e-08 34.3 0.1 1.7 1 0 0 1 1 1 1 Variant SH3 domain tRNA-synt_2d PF01409.20 EXF80437.1 - 5.6e-48 163.6 0.3 8.2e-25 87.7 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) FDX-ACB PF03147.14 EXF80437.1 - 8e-25 87.1 0.0 1.8e-24 85.9 0.0 1.7 1 0 0 1 1 1 1 Ferredoxin-fold anticodon binding domain Calcipressin PF04847.12 EXF80439.1 - 1.8e-51 174.6 0.1 2.3e-51 174.2 0.1 1.1 1 0 0 1 1 1 1 Calcipressin DUF2236 PF09995.9 EXF80440.1 - 5.5e-34 118.3 0.7 5.5e-34 118.3 0.7 1.7 2 0 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2236) SUIM_assoc PF16619.5 EXF80440.1 - 0.045 13.8 2.4 0.1 12.7 1.7 1.8 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 T3SS_NleG PF06416.12 EXF80440.1 - 0.062 13.2 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 Effector protein NleG Comm PF15957.5 EXF80440.1 - 0.16 12.3 0.0 0.3 11.4 0.0 1.4 1 0 0 1 1 1 0 Commissureless Neugrin PF06413.11 EXF80441.1 - 1.8e-10 41.2 0.2 1.8e-10 41.2 0.2 1.7 2 1 0 2 2 2 1 Neugrin MRP-L20 PF12824.7 EXF80441.1 - 2.5e-06 27.7 2.8 2.5e-06 27.7 2.8 2.0 2 1 0 2 2 2 1 Mitochondrial ribosomal protein subunit L20 Skp1 PF01466.19 EXF80441.1 - 0.0021 18.1 0.2 0.0021 18.1 0.2 1.8 2 0 0 2 2 2 1 Skp1 family, dimerisation domain HET PF06985.11 EXF80442.1 - 1.4e-09 38.5 0.9 2.3e-08 34.5 0.9 2.5 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) ATP-grasp_2 PF08442.10 EXF80443.1 - 4.4e-76 255.0 0.8 4.4e-76 255.0 0.8 1.7 2 0 0 2 2 2 1 ATP-grasp domain Ligase_CoA PF00549.19 EXF80443.1 - 3.7e-27 95.0 0.4 7.8e-27 94.0 0.4 1.6 1 0 0 1 1 1 1 CoA-ligase ATP-grasp_5 PF13549.6 EXF80443.1 - 6.7e-07 29.0 0.1 1.5e-06 27.9 0.1 1.6 1 0 0 1 1 1 1 ATP-grasp domain GARS_A PF01071.19 EXF80443.1 - 0.0016 18.2 1.9 0.035 13.9 0.2 2.6 2 1 0 2 2 2 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain OKR_DC_1_N PF03709.15 EXF80443.1 - 0.12 12.6 0.2 0.7 10.2 0.0 2.4 2 1 0 2 2 2 0 Orn/Lys/Arg decarboxylase, N-terminal domain AzlD PF05437.12 EXF80444.1 - 0.03 14.5 0.4 0.059 13.6 0.4 1.5 1 0 0 1 1 1 0 Branched-chain amino acid transport protein (AzlD) Fructosamin_kin PF03881.14 EXF80446.1 - 3.4e-71 239.8 0.0 4e-71 239.6 0.0 1.0 1 0 0 1 1 1 1 Fructosamine kinase APH PF01636.23 EXF80446.1 - 0.00028 20.9 0.0 0.00048 20.1 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family DUF3849 PF12960.7 EXF80446.1 - 0.072 13.1 0.0 0.12 12.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3849) DUF1679 PF07914.11 EXF80446.1 - 0.1 11.5 0.0 0.14 11.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) RHD3 PF05879.12 EXF80447.1 - 0 1058.9 0.0 0 1058.6 0.0 1.0 1 0 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) GBP PF02263.19 EXF80447.1 - 1.9e-09 37.2 0.4 3.1e-09 36.5 0.4 1.2 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain Dynamin_N PF00350.23 EXF80447.1 - 3.1e-07 30.6 0.1 6e-07 29.7 0.1 1.5 1 0 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 EXF80447.1 - 5e-05 23.4 0.0 0.00011 22.3 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_28 PF13521.6 EXF80447.1 - 0.00037 20.8 0.0 0.0017 18.7 0.0 2.2 2 0 0 2 2 2 1 AAA domain Septin PF00735.18 EXF80447.1 - 0.031 13.5 0.1 0.052 12.8 0.1 1.3 1 0 0 1 1 1 0 Septin CENP-C_C PF11699.8 EXF80448.1 - 1.4e-34 118.1 0.3 2.6e-34 117.3 0.3 1.5 1 0 0 1 1 1 1 Mif2/CENP-C like Mif2_N PF15624.6 EXF80448.1 - 1e-33 116.9 5.2 1e-33 116.9 5.2 3.9 3 1 1 4 4 4 1 Kinetochore CENP-C fungal homologue, Mif2, N-terminal Cupin_2 PF07883.11 EXF80448.1 - 2e-07 30.6 0.0 5.9e-07 29.1 0.0 1.8 1 0 0 1 1 1 1 Cupin domain Cupin_3 PF05899.12 EXF80448.1 - 0.0012 18.5 0.0 0.0038 16.9 0.0 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF861) Cupin_1 PF00190.22 EXF80448.1 - 0.018 14.7 0.1 0.033 13.8 0.1 1.3 1 0 0 1 1 1 0 Cupin Cupin_6 PF12852.7 EXF80448.1 - 0.1 12.3 0.0 0.28 10.9 0.0 1.7 1 0 0 1 1 1 0 Cupin RNase_HII PF01351.18 EXF80449.1 - 4.8e-47 160.4 0.0 6.5e-47 159.9 0.0 1.2 1 0 0 1 1 1 1 Ribonuclease HII HSP70 PF00012.20 EXF80451.1 - 3.1e-259 861.2 6.2 3.5e-259 861.0 6.2 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EXF80451.1 - 5.4e-17 61.6 0.1 1.3e-15 57.1 0.0 2.1 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.16 EXF80451.1 - 0.0013 18.5 0.0 0.003 17.3 0.0 1.6 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain Hydantoinase_A PF01968.18 EXF80451.1 - 0.0093 15.3 0.1 0.024 13.9 0.1 1.7 1 0 0 1 1 1 1 Hydantoinase/oxoprolinase FtsA PF14450.6 EXF80451.1 - 0.011 16.1 0.5 11 6.5 0.0 3.4 3 1 0 3 3 3 0 Cell division protein FtsA BcrAD_BadFG PF01869.20 EXF80451.1 - 0.035 13.6 0.0 2.2 7.7 0.0 2.3 2 0 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family FAM91_C PF14648.6 EXF80451.1 - 0.18 10.6 0.2 0.35 9.7 0.2 1.4 1 0 0 1 1 1 0 FAM91 C-terminus Golgin_A5 PF09787.9 EXF80451.1 - 0.48 9.8 8.1 0.48 9.9 5.5 1.9 2 0 0 2 2 2 0 Golgin subfamily A member 5 MutS_III PF05192.18 EXF80451.1 - 2.6 8.2 5.1 9.2 6.4 0.7 2.5 2 1 0 2 2 2 0 MutS domain III DUF3128 PF11326.8 EXF80452.1 - 1.3e-27 96.0 5.7 2.3e-27 95.2 5.7 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3128) Ndc1_Nup PF09531.10 EXF80452.1 - 0.061 12.0 4.3 0.06 12.0 4.3 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup RNA12 PF10443.9 EXF80453.1 - 3.2e-160 533.7 0.5 5.1e-160 533.0 0.5 1.3 1 0 0 1 1 1 1 RNA12 protein RRM_1 PF00076.22 EXF80453.1 - 3.5e-06 26.7 0.0 1.5e-05 24.7 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ATPase_2 PF01637.18 EXF80453.1 - 0.00032 20.7 1.2 0.036 14.0 0.0 2.6 2 1 0 2 2 2 1 ATPase domain predominantly from Archaea KH_5 PF13184.6 EXF80453.1 - 0.083 13.0 0.0 0.22 11.6 0.0 1.7 1 0 0 1 1 1 0 NusA-like KH domain DUF2487 PF10673.9 EXF80453.1 - 0.086 12.9 0.0 0.18 11.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2487) LDcluster4 PF18306.1 EXF80453.1 - 0.15 11.7 0.0 0.34 10.5 0.0 1.7 1 0 0 1 1 1 0 SLOG cluster4 family HSP70 PF00012.20 EXF80454.1 - 9.3e-05 20.8 0.0 0.00012 20.5 0.0 1.0 1 0 0 1 1 1 1 Hsp70 protein Sugar_tr PF00083.24 EXF80455.1 - 3e-90 303.3 22.1 3.5e-90 303.0 22.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF80455.1 - 7.9e-13 48.0 47.0 5.7e-11 41.9 23.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MS_channel PF00924.18 EXF80456.1 - 7.9e-19 68.0 2.7 1.3e-18 67.3 2.7 1.3 1 0 0 1 1 1 1 Mechanosensitive ion channel EF-hand_1 PF00036.32 EXF80456.1 - 0.035 13.7 0.6 0.084 12.5 0.6 1.7 1 0 0 1 1 1 0 EF hand EF-hand_6 PF13405.6 EXF80456.1 - 0.071 13.1 0.2 0.33 11.0 0.1 2.2 2 0 0 2 2 2 0 EF-hand domain EF-hand_5 PF13202.6 EXF80456.1 - 0.073 12.6 0.2 0.16 11.5 0.2 1.6 1 0 0 1 1 1 0 EF hand E1-E2_ATPase PF00122.20 EXF80456.1 - 2.9 7.4 5.7 4.7 6.7 1.2 2.4 2 0 0 2 2 2 0 E1-E2 ATPase DLH PF01738.18 EXF80457.1 - 3.6e-23 82.3 0.0 5.1e-23 81.8 0.0 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family Abp2 PF09441.10 EXF80458.1 - 1.1e-88 295.7 0.0 1.7e-88 295.2 0.0 1.3 1 0 0 1 1 1 1 ARS binding protein 2 Sds3 PF08598.11 EXF80460.1 - 2.1e-23 83.5 11.5 3.5e-23 82.8 11.5 1.5 1 1 0 1 1 1 1 Sds3-like SLAC1 PF03595.17 EXF80461.1 - 1.7e-57 195.2 34.2 2.3e-57 194.7 34.2 1.1 1 0 0 1 1 1 1 Voltage-dependent anion channel COG5 PF10392.9 EXF80461.1 - 0.011 15.9 0.3 0.12 12.5 0.0 2.8 3 1 0 3 3 3 0 Golgi transport complex subunit 5 DUF5056 PF16479.5 EXF80461.1 - 0.072 13.3 0.2 0.21 11.8 0.2 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF5056) COG7 PF10191.9 EXF80461.1 - 0.14 10.3 0.0 0.34 9.1 0.0 1.6 1 0 0 1 1 1 0 Golgi complex component 7 (COG7) DUF4795 PF16043.5 EXF80461.1 - 0.76 9.3 4.3 0.25 10.9 1.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4795) Cdh1_DBD_1 PF18196.1 EXF80461.1 - 1.4 9.3 3.4 4.8 7.5 0.8 2.2 2 0 0 2 2 2 0 Chromodomain helicase DNA-binding domain 1 Ribosomal_S5_C PF03719.15 EXF80464.1 - 8.8e-22 76.3 0.2 8.7e-21 73.2 0.0 2.7 4 0 0 4 4 4 1 Ribosomal protein S5, C-terminal domain Ribosomal_S5 PF00333.20 EXF80464.1 - 2.7e-18 65.7 1.1 1.1e-17 63.8 0.4 2.2 2 0 0 2 2 2 1 Ribosomal protein S5, N-terminal domain DUF3546 PF12066.8 EXF80464.1 - 0.16 12.1 2.3 2.4 8.4 0.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3546) DASH_Dad3 PF08656.10 EXF80465.1 - 1.1e-33 115.1 0.5 1.3e-33 114.9 0.5 1.1 1 0 0 1 1 1 1 DASH complex subunit Dad3 CorA PF01544.18 EXF80466.1 - 0.00047 19.6 0.0 0.00087 18.7 0.0 1.3 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein PARP PF00644.20 EXF80467.1 - 1.2e-14 54.3 0.0 2.7e-14 53.2 0.0 1.6 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain UQ_con PF00179.26 EXF80467.1 - 5.8e-06 26.0 0.0 1.9e-05 24.3 0.0 1.8 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme PP2C PF00481.21 EXF80468.1 - 1.7e-42 145.9 0.0 2.8e-42 145.1 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 EXF80468.1 - 0.021 14.7 0.1 0.69 9.8 0.0 2.6 3 0 0 3 3 3 0 Stage II sporulation protein E (SpoIIE) Pkinase PF00069.25 EXF80469.1 - 6.3e-75 251.9 0.0 8.5e-75 251.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF80469.1 - 1.2e-30 106.6 0.0 5.8e-22 78.2 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EXF80469.1 - 1.5e-06 27.8 0.1 0.88 8.8 0.0 3.1 3 0 0 3 3 3 3 Kinase-like Pkinase_fungal PF17667.1 EXF80469.1 - 0.012 14.4 0.0 0.021 13.6 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Kdo PF06293.14 EXF80469.1 - 0.036 13.4 0.0 0.059 12.7 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EXF80469.1 - 0.065 13.2 0.0 1.6 8.6 0.0 2.3 1 1 1 2 2 2 0 Phosphotransferase enzyme family FOXP-CC PF16159.5 EXF80470.1 - 0.014 16.0 4.3 0.045 14.4 3.8 2.0 1 1 1 2 2 2 0 FOXP coiled-coil domain adh_short PF00106.25 EXF80471.1 - 1.2e-25 90.1 0.0 1.6e-25 89.7 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF80471.1 - 8.2e-21 74.6 0.0 1.1e-20 74.2 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF80471.1 - 9.2e-05 22.4 0.0 0.00015 21.8 0.0 1.4 1 1 0 1 1 1 1 KR domain ABC_sub_bind PF04392.12 EXF80471.1 - 0.05 12.8 0.0 0.082 12.1 0.0 1.3 1 0 0 1 1 1 0 ABC transporter substrate binding protein CoA_binding_2 PF13380.6 EXF80471.1 - 0.11 13.0 0.0 0.18 12.3 0.0 1.3 1 0 0 1 1 1 0 CoA binding domain DFRP_C PF16543.5 EXF80472.1 - 5.8e-26 90.8 9.5 5.8e-26 90.8 9.5 3.7 3 0 0 3 3 3 1 DRG Family Regulatory Proteins, Tma46 zf-CCCH PF00642.24 EXF80472.1 - 3.3e-06 26.9 8.8 1.7e-05 24.6 2.0 2.9 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 EXF80472.1 - 3.1e-05 23.7 11.5 0.0035 17.1 4.1 3.3 3 0 0 3 3 3 2 CCCH-type zinc finger Torus PF16131.5 EXF80472.1 - 3.7e-05 24.4 18.8 5.4e-05 23.9 5.4 3.6 2 1 1 3 3 3 2 Torus domain zf_CCCH_4 PF18345.1 EXF80472.1 - 0.00046 20.1 8.9 0.00046 20.1 8.9 3.2 3 0 0 3 3 3 2 Zinc finger domain zf-CCCH_3 PF15663.5 EXF80472.1 - 0.0013 19.0 2.1 0.032 14.4 0.9 2.6 2 0 0 2 2 2 1 Zinc-finger containing family zf-CCCH_2 PF14608.6 EXF80472.1 - 1.9 9.1 17.5 1.2 9.7 7.6 2.9 2 1 0 2 2 2 0 RNA-binding, Nab2-type zinc finger Ost4 PF10215.9 EXF80473.1 - 2.4e-19 68.8 0.6 3.8e-19 68.2 0.6 1.3 1 0 0 1 1 1 1 Oligosaccaryltransferase RRM_1 PF00076.22 EXF80474.1 - 6.5e-15 54.7 0.0 1.1e-14 54.0 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication PF13865.6 EXF80474.1 - 3.6e-05 24.2 4.3 3.6e-05 24.2 4.3 3.1 2 1 1 3 3 3 1 C-terminal duplication domain of Friend of PRMT1 RRM_occluded PF16842.5 EXF80474.1 - 0.0092 15.8 0.0 0.018 14.9 0.0 1.5 1 0 0 1 1 1 1 Occluded RNA-recognition motif CS PF04969.16 EXF80475.1 - 4.6e-10 40.4 0.0 7.2e-10 39.8 0.0 1.3 1 0 0 1 1 1 1 CS domain Snf7 PF03357.21 EXF80476.1 - 2.2e-24 86.0 13.4 2.2e-24 86.0 13.4 1.9 2 0 0 2 2 2 1 Snf7 TPR_MLP1_2 PF07926.12 EXF80476.1 - 0.16 12.1 14.3 0.18 11.8 8.2 2.6 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein Fib_alpha PF08702.10 EXF80476.1 - 0.77 9.9 8.0 0.59 10.3 5.6 1.9 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family bZIP_1 PF00170.21 EXF80477.1 - 2e-07 31.0 2.6 2.8e-07 30.5 2.6 1.2 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EXF80477.1 - 0.00012 22.1 4.2 0.00021 21.3 4.2 1.4 1 0 0 1 1 1 1 Basic region leucine zipper SOBP PF15279.6 EXF80477.1 - 0.11 13.1 1.4 0.11 13.0 1.4 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein S1-P1_nuclease PF02265.16 EXF80478.1 - 1.9e-70 237.6 0.1 2.2e-70 237.4 0.1 1.0 1 0 0 1 1 1 1 S1/P1 Nuclease PQ-loop PF04193.14 EXF80479.1 - 3.7e-40 135.5 6.7 6.3e-21 73.9 0.1 2.8 2 0 0 2 2 2 2 PQ loop repeat TMEM132D_C PF15706.5 EXF80479.1 - 0.022 14.5 0.0 0.052 13.3 0.0 1.6 1 0 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term F-box-like PF12937.7 EXF80480.1 - 2.3e-06 27.4 0.4 7.6e-06 25.7 0.4 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EXF80480.1 - 2.1e-05 24.3 0.5 0.0001 22.1 0.1 2.3 2 0 0 2 2 2 1 F-box domain Bac_rhamnosid6H PF17389.2 EXF80481.1 - 3.4e-13 49.6 4.6 3.1e-11 43.1 3.4 2.1 1 1 1 2 2 2 2 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain Glyco_hydro_36 PF17167.4 EXF80481.1 - 0.0092 14.7 0.1 0.02 13.6 0.1 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase 36 superfamily, catalytic domain CFEM PF05730.11 EXF80482.1 - 1.1e-13 51.0 9.7 2.1e-13 50.1 9.7 1.5 1 0 0 1 1 1 1 CFEM domain GMC_oxred_N PF00732.19 EXF80483.1 - 5.2e-26 91.7 0.0 7.8e-18 64.9 0.0 3.1 2 1 0 3 3 3 3 GMC oxidoreductase GMC_oxred_C PF05199.13 EXF80483.1 - 6.5e-21 75.4 0.0 1.1e-20 74.6 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase Pyr_redox_2 PF07992.14 EXF80483.1 - 0.00015 21.1 0.0 0.00026 20.3 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EXF80483.1 - 0.00022 21.4 0.2 0.00062 20.0 0.2 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 EXF80483.1 - 0.0054 16.0 0.1 0.0079 15.5 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain Lycopene_cycl PF05834.12 EXF80483.1 - 0.0072 15.4 0.2 0.01 14.9 0.2 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein FAD_binding_2 PF00890.24 EXF80483.1 - 0.01 15.0 0.3 0.028 13.5 0.2 1.7 2 0 0 2 2 2 0 FAD binding domain Pyr_redox_3 PF13738.6 EXF80483.1 - 0.024 13.9 0.5 5.8 6.1 0.0 2.6 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EXF80483.1 - 0.076 11.7 0.1 0.11 11.2 0.1 1.2 1 0 0 1 1 1 0 HI0933-like protein EI24 PF07264.11 EXF80485.1 - 2.9e-14 53.7 3.2 4.5e-14 53.1 3.2 1.3 1 1 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) SPC12 PF06645.13 EXF80486.1 - 0.0075 16.3 3.6 4.6 7.4 0.0 4.6 4 0 0 4 4 4 2 Microsomal signal peptidase 12 kDa subunit (SPC12) SURF4 PF02077.15 EXF80487.1 - 2.2e-97 325.8 8.6 2.5e-97 325.7 8.6 1.0 1 0 0 1 1 1 1 SURF4 family Methyltransf_23 PF13489.6 EXF80488.1 - 5.7e-21 75.0 0.0 8.9e-21 74.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF80488.1 - 1e-11 45.4 0.0 1.9e-11 44.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF80488.1 - 1.1e-11 44.7 0.0 7e-11 42.1 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF80488.1 - 2.5e-10 41.0 0.0 1.1e-09 38.9 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF80488.1 - 1.9e-08 34.9 0.0 3.1e-08 34.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 EXF80488.1 - 0.0086 15.6 0.0 0.019 14.5 0.0 1.5 1 0 0 1 1 1 1 Putative methyltransferase MTS PF05175.14 EXF80488.1 - 0.01 15.4 0.0 0.016 14.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Ubie_methyltran PF01209.18 EXF80488.1 - 0.042 13.2 0.0 0.66 9.3 0.0 2.6 2 1 0 2 2 2 0 ubiE/COQ5 methyltransferase family FtsJ PF01728.19 EXF80488.1 - 0.045 13.9 0.0 0.066 13.3 0.0 1.2 1 0 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_2 PF00891.18 EXF80488.1 - 0.046 13.0 0.0 0.18 11.1 0.0 2.0 2 1 0 2 2 2 0 O-methyltransferase domain CMAS PF02353.20 EXF80488.1 - 0.078 12.3 0.0 0.18 11.1 0.0 1.5 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase Tyosinase_C PF18132.1 EXF80489.1 - 8.4e-34 116.9 0.0 1.5e-33 116.1 0.0 1.4 1 0 0 1 1 1 1 Tyosinase C-terminal domain Tyrosinase PF00264.20 EXF80489.1 - 7.6e-25 88.5 1.1 1.1e-22 81.5 0.1 2.4 2 0 0 2 2 2 2 Common central domain of tyrosinase p450 PF00067.22 EXF80490.1 - 1.2e-69 235.2 0.0 1.5e-69 235.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 OCD_Mu_crystall PF02423.15 EXF80491.1 - 1.1e-16 60.7 0.0 9e-14 51.1 0.0 3.0 1 1 0 1 1 1 1 Ornithine cyclodeaminase/mu-crystallin family Shikimate_DH PF01488.20 EXF80491.1 - 2.4e-07 30.9 0.2 0.00056 20.0 0.1 2.3 2 0 0 2 2 2 2 Shikimate / quinate 5-dehydrogenase Sacchrp_dh_NADP PF03435.18 EXF80491.1 - 0.022 15.0 0.0 0.046 14.0 0.0 1.6 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Oxidored_FMN PF00724.20 EXF80492.1 - 6.1e-66 223.0 0.0 2.1e-62 211.4 0.0 2.1 1 1 1 2 2 2 2 NADH:flavin oxidoreductase / NADH oxidase family Meth_synt_2 PF01717.18 EXF80493.1 - 3.2e-150 499.9 0.0 4.7e-144 479.6 0.0 2.3 2 0 0 2 2 2 2 Cobalamin-independent synthase, Catalytic domain Meth_synt_1 PF08267.12 EXF80493.1 - 6.3e-121 403.7 0.0 4.8e-113 377.8 0.0 3.6 3 1 1 4 4 4 2 Cobalamin-independent synthase, N-terminal domain URO-D PF01208.17 EXF80493.1 - 1.5e-05 24.3 0.0 0.0028 16.9 0.0 2.5 2 0 0 2 2 2 2 Uroporphyrinogen decarboxylase (URO-D) DUF3018 PF11455.8 EXF80493.1 - 0.12 12.3 0.2 0.61 10.1 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3018) VbhA PF18495.1 EXF80493.1 - 0.14 12.0 0.0 18 5.3 0.0 2.9 2 0 0 2 2 2 0 Antitoxin VbhA But2 PF09792.9 EXF80495.1 - 0.033 14.6 0.0 0.05 14.0 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin 3 binding protein But2 C-terminal domain Clr5 PF14420.6 EXF80498.1 - 2.7e-19 69.1 3.3 6.8e-19 67.9 3.3 1.7 1 0 0 1 1 1 1 Clr5 domain RskA PF10099.9 EXF80498.1 - 5.4e-05 23.6 1.7 6.3e-05 23.3 0.0 1.9 1 1 1 2 2 2 1 Anti-sigma-K factor rskA YCII PF03795.14 EXF80498.1 - 0.79 10.2 0.0 0.79 10.2 0.0 2.5 3 0 0 3 3 3 0 YCII-related domain PhnG PF06754.12 EXF80498.1 - 2 8.3 8.6 8 6.4 0.2 2.4 2 0 0 2 2 2 0 Phosphonate metabolism protein PhnG PH PF00169.29 EXF80499.1 - 6e-05 23.5 0.0 0.00011 22.6 0.0 1.5 1 0 0 1 1 1 1 PH domain Apolipoprotein PF01442.18 EXF80499.1 - 0.021 14.7 0.9 0.03 14.2 0.2 1.6 2 0 0 2 2 2 0 Apolipoprotein A1/A4/E domain SapC PF07277.11 EXF80499.1 - 0.064 12.8 0.1 0.12 11.9 0.1 1.4 1 0 0 1 1 1 0 SapC DUF3106 PF11304.8 EXF80499.1 - 0.13 12.8 0.1 0.63 10.5 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3106) Golgin_A5 PF09787.9 EXF80499.1 - 0.14 11.6 2.4 0.29 10.6 0.1 2.1 2 0 0 2 2 2 0 Golgin subfamily A member 5 Chorion_2 PF03964.15 EXF80499.1 - 0.6 11.0 6.2 33 5.4 3.7 2.7 1 1 1 2 2 2 0 Chorion family 2 Arrestin_C PF02752.22 EXF80500.1 - 1.2e-16 61.4 0.0 3.2e-16 60.0 0.0 1.7 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 EXF80500.1 - 1.9e-15 57.2 0.0 3.3e-15 56.4 0.0 1.3 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain LDB19 PF13002.7 EXF80500.1 - 0.0033 17.1 0.0 0.0064 16.2 0.0 1.5 1 0 0 1 1 1 1 Arrestin_N terminal like Sarcoglycan_2 PF05510.13 EXF80500.1 - 0.019 13.8 0.0 0.074 11.8 0.0 1.8 2 0 0 2 2 2 0 Sarcoglycan alpha/epsilon WD40 PF00400.32 EXF80501.1 - 2.6e-13 50.2 9.6 0.0012 19.7 0.3 5.9 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EXF80501.1 - 7.6e-09 35.8 0.0 0.00021 21.5 0.0 3.9 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 EXF80501.1 - 0.00011 22.0 0.1 0.41 10.7 0.0 3.2 3 0 0 3 3 3 2 WD40-like Beta Propeller Repeat eIF2A PF08662.11 EXF80501.1 - 0.00027 20.9 0.1 0.00077 19.4 0.0 1.7 1 1 0 1 1 1 1 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.16 EXF80501.1 - 0.0099 14.4 0.0 0.017 13.6 0.0 1.3 1 0 0 1 1 1 1 Cytochrome D1 heme domain VID27 PF08553.10 EXF80501.1 - 0.065 12.3 0.0 0.1 11.7 0.0 1.2 1 0 0 1 1 1 0 VID27 C-terminal WD40-like domain EF_assoc_2 PF08356.12 EXF80502.1 - 8.2e-35 118.7 0.0 1.6e-34 117.7 0.0 1.5 1 0 0 1 1 1 1 EF hand associated EF_assoc_1 PF08355.12 EXF80502.1 - 4e-31 106.4 1.1 8.1e-31 105.5 1.1 1.5 1 0 0 1 1 1 1 EF hand associated Ras PF00071.22 EXF80502.1 - 3.3e-21 75.6 0.0 1.5e-13 50.6 0.0 2.2 2 0 0 2 2 2 2 Ras family Roc PF08477.13 EXF80502.1 - 9.3e-14 51.7 0.0 1.1e-08 35.3 0.0 2.4 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 EXF80502.1 - 1.8e-09 37.7 0.0 0.0002 21.4 0.0 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase EF-hand_7 PF13499.6 EXF80502.1 - 9.9e-07 29.1 0.2 0.0019 18.6 0.1 2.6 2 0 0 2 2 2 2 EF-hand domain pair AAA_29 PF13555.6 EXF80502.1 - 6.1e-06 25.9 0.1 0.0059 16.3 0.0 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_16 PF13191.6 EXF80502.1 - 7.2e-06 26.5 0.1 0.013 15.9 0.1 2.4 2 0 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 EXF80502.1 - 1.2e-05 25.3 0.0 0.35 10.8 0.0 3.3 2 1 1 3 3 3 2 RsgA GTPase EF-hand_6 PF13405.6 EXF80502.1 - 2.6e-05 23.8 3.7 0.021 14.7 0.3 2.7 2 0 0 2 2 2 2 EF-hand domain AAA_22 PF13401.6 EXF80502.1 - 2.8e-05 24.4 0.0 0.42 10.9 0.0 2.6 2 1 0 2 2 2 2 AAA domain Dynamin_N PF00350.23 EXF80502.1 - 3.4e-05 24.0 0.5 0.61 10.1 0.2 3.3 3 1 1 4 4 3 2 Dynamin family EF-hand_1 PF00036.32 EXF80502.1 - 7.3e-05 22.0 3.6 0.013 15.0 0.8 2.7 2 0 0 2 2 2 1 EF hand ABC_tran PF00005.27 EXF80502.1 - 9e-05 23.0 0.0 0.28 11.7 0.0 2.4 2 0 0 2 2 2 2 ABC transporter AAA_24 PF13479.6 EXF80502.1 - 0.00059 19.6 0.0 0.13 12.0 0.0 2.8 3 0 0 3 3 3 1 AAA domain RNA_helicase PF00910.22 EXF80502.1 - 0.0012 19.2 0.0 0.43 11.0 0.0 2.6 2 0 0 2 2 2 1 RNA helicase DUF815 PF05673.13 EXF80502.1 - 0.0041 16.3 0.1 1.6 7.8 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF815) GTP_EFTU PF00009.27 EXF80502.1 - 0.0043 16.6 0.0 5.8 6.4 0.0 3.1 2 1 0 3 3 3 0 Elongation factor Tu GTP binding domain AAA_28 PF13521.6 EXF80502.1 - 0.0047 17.2 0.0 5.2 7.3 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 EXF80502.1 - 0.0073 16.5 0.0 1.8 8.7 0.0 2.5 2 0 0 2 2 2 1 AAA domain IIGP PF05049.13 EXF80502.1 - 0.0085 15.2 0.0 1.7 7.6 0.0 2.3 2 0 0 2 2 2 1 Interferon-inducible GTPase (IIGP) Ploopntkinase3 PF18751.1 EXF80502.1 - 0.012 15.5 0.0 1.6 8.6 0.0 2.4 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 NACHT PF05729.12 EXF80502.1 - 0.015 15.2 0.1 3.3 7.6 0.0 2.9 3 0 0 3 3 2 0 NACHT domain Septin PF00735.18 EXF80502.1 - 0.016 14.5 0.0 0.42 9.8 0.0 2.1 2 0 0 2 2 2 0 Septin EF-hand_10 PF14788.6 EXF80502.1 - 0.02 14.8 1.2 0.35 10.8 0.1 2.4 2 0 0 2 2 2 0 EF hand AAA_18 PF13238.6 EXF80502.1 - 0.025 15.1 0.0 1.8 9.1 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 EXF80502.1 - 0.042 14.4 0.2 3.5 8.1 0.0 2.4 2 0 0 2 2 2 0 AAA domain Arf PF00025.21 EXF80502.1 - 0.073 12.5 0.0 10 5.5 0.0 2.7 2 1 0 2 2 2 0 ADP-ribosylation factor family AAA_7 PF12775.7 EXF80502.1 - 0.076 12.5 0.0 1.4 8.4 0.0 2.2 2 0 0 2 2 2 0 P-loop containing dynein motor region Viral_helicase1 PF01443.18 EXF80502.1 - 0.08 12.7 0.0 3.2 7.4 0.0 2.4 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase EF-hand_5 PF13202.6 EXF80502.1 - 0.11 12.0 6.1 0.29 10.7 2.7 2.6 2 0 0 2 2 2 0 EF hand SMC_N PF02463.19 EXF80502.1 - 0.12 11.8 0.1 4.4 6.7 0.0 2.1 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_25 PF13481.6 EXF80502.1 - 0.14 11.7 0.1 15 5.1 0.0 2.4 2 0 0 2 2 2 0 AAA domain AIG1 PF04548.16 EXF80502.1 - 0.25 10.7 0.2 1.2 8.4 0.2 2.0 2 0 0 2 2 2 0 AIG1 family EF-hand_8 PF13833.6 EXF80502.1 - 1.6 8.6 4.0 9.9 6.1 0.8 2.5 2 0 0 2 2 2 0 EF-hand domain pair adh_short_C2 PF13561.6 EXF80503.1 - 2.6e-56 190.8 7.7 3.5e-56 190.4 7.7 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF80503.1 - 2.2e-48 164.3 5.0 3.1e-48 163.8 5.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EXF80503.1 - 1.6e-13 51.0 3.9 2.7e-13 50.2 3.9 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EXF80503.1 - 0.0065 16.0 2.1 0.015 14.7 2.1 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Ketoacyl-synt_C PF02801.22 EXF80503.1 - 0.025 14.6 0.2 0.063 13.3 0.2 1.6 1 0 0 1 1 1 0 Beta-ketoacyl synthase, C-terminal domain PNGaseA PF12222.8 EXF80503.1 - 0.03 13.2 1.1 0.031 13.1 0.0 1.5 2 0 0 2 2 2 0 Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A THF_DHG_CYH_C PF02882.19 EXF80503.1 - 0.031 13.6 1.3 0.044 13.1 0.5 1.7 2 0 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain 3HCDH_N PF02737.18 EXF80503.1 - 1.4 8.8 5.9 0.2 11.5 1.9 1.7 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Zds_C PF08632.10 EXF80504.1 - 1.1e-27 95.5 1.4 2e-27 94.7 1.4 1.5 1 0 0 1 1 1 1 Activator of mitotic machinery Cdc14 phosphatase activation C-term DUF2076 PF09849.9 EXF80504.1 - 0.12 12.4 0.1 0.12 12.4 0.1 5.2 4 2 1 5 5 5 0 Uncharacterized protein conserved in bacteria (DUF2076) DUF2433 PF10360.9 EXF80505.1 - 2e-49 166.8 0.0 3e-49 166.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2433) Metallophos PF00149.28 EXF80505.1 - 0.00049 20.7 0.0 0.0015 19.1 0.0 1.9 2 1 0 2 2 2 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EXF80505.1 - 0.013 15.7 0.0 0.037 14.2 0.0 1.8 1 1 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain Ubie_methyltran PF01209.18 EXF80506.1 - 3.1e-77 259.0 0.0 3.9e-77 258.7 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.6 EXF80506.1 - 2.4e-15 57.0 0.0 4.2e-15 56.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF80506.1 - 1.3e-13 51.4 0.0 2.8e-13 50.3 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF80506.1 - 8.5e-12 45.7 0.0 1.3e-11 45.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF80506.1 - 2.1e-11 43.8 0.0 2.7e-11 43.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EXF80506.1 - 3e-08 33.7 0.0 5e-08 33.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 EXF80506.1 - 0.023 14.5 0.0 0.087 12.7 0.0 1.9 3 0 0 3 3 3 0 Hypothetical methyltransferase Aminotran_4 PF01063.19 EXF80507.1 - 3.7e-30 105.5 0.0 6.2e-30 104.7 0.0 1.4 1 0 0 1 1 1 1 Amino-transferase class IV Fungal_trans PF04082.18 EXF80507.1 - 1e-21 77.2 0.1 1.5e-21 76.6 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF80507.1 - 0.0029 17.7 3.2 0.0063 16.6 3.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF4094 PF13334.6 EXF80507.1 - 0.12 12.8 0.3 0.45 11.0 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4094) DUF4148 PF13663.6 EXF80507.1 - 2.1 8.6 3.6 1.8 8.8 1.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4148) HalX PF08663.10 EXF80507.1 - 2.3 8.6 9.4 10 6.5 0.0 3.4 3 0 0 3 3 3 0 HalX domain MFS_1 PF07690.16 EXF80508.1 - 2.1e-34 119.0 25.6 2.1e-34 119.0 25.6 1.7 2 0 0 2 2 2 1 Major Facilitator Superfamily MFS_4 PF06779.14 EXF80508.1 - 3.7e-06 26.5 3.7 3.7e-06 26.5 3.7 3.2 2 1 1 3 3 3 1 Uncharacterised MFS-type transporter YbfB DSRB PF10781.9 EXF80508.1 - 0.023 14.3 0.0 0.069 12.8 0.0 1.8 1 0 0 1 1 1 0 Dextransucrase DSRB Wzy_C_2 PF11846.8 EXF80508.1 - 1.8 8.4 6.4 3.1 7.7 0.0 3.0 3 1 1 4 4 4 0 Virulence factor membrane-bound polymerase, C-terminal UPF0182 PF03699.13 EXF80508.1 - 1.9 6.5 6.1 1.1 7.3 4.2 1.5 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0182) E1_dh PF00676.20 EXF80509.1 - 1.5e-88 296.6 0.0 1.8e-88 296.3 0.0 1.1 1 0 0 1 1 1 1 Dehydrogenase E1 component TPP_enzyme_C PF02775.21 EXF80509.1 - 0.00011 22.0 0.1 0.0064 16.3 0.0 2.9 2 1 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain DXP_synthase_N PF13292.6 EXF80509.1 - 0.11 11.7 0.0 0.27 10.4 0.0 1.5 2 0 0 2 2 2 0 1-deoxy-D-xylulose-5-phosphate synthase HECT PF00632.25 EXF80510.1 - 6.4e-77 259.0 0.0 9.6e-77 258.5 0.0 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) HEAT PF02985.22 EXF80510.1 - 0.021 15.0 0.2 7.7 7.1 0.0 4.3 4 0 0 4 4 4 0 HEAT repeat HEAT_EZ PF13513.6 EXF80510.1 - 0.036 14.6 0.1 0.75 10.4 0.0 3.3 3 0 0 3 3 3 0 HEAT-like repeat Arm PF00514.23 EXF80510.1 - 0.036 14.1 11.4 58 3.9 0.0 7.4 7 2 2 9 9 9 0 Armadillo/beta-catenin-like repeat DUF1833 PF08875.11 EXF80510.1 - 0.11 12.0 0.1 0.26 10.8 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1833) CLASP_N PF12348.8 EXF80510.1 - 0.12 11.9 0.1 0.35 10.4 0.0 1.7 2 0 0 2 2 2 0 CLASP N terminal TFIIA PF03153.13 EXF80510.1 - 0.3 11.0 36.6 0.0099 15.9 18.9 2.9 3 0 0 3 3 3 0 Transcription factor IIA, alpha/beta subunit RRN3 PF05327.11 EXF80510.1 - 2.4 6.6 14.8 0.51 8.8 6.9 2.5 2 0 0 2 2 2 0 RNA polymerase I specific transcription initiation factor RRN3 Telomere_reg-2 PF10193.9 EXF80510.1 - 5.5 7.5 5.9 5.8 7.4 0.1 3.4 4 0 0 4 4 4 0 Telomere length regulation protein Sec3_C PF09763.9 EXF80511.1 - 9.8e-244 810.9 2.4 1.2e-243 810.6 2.4 1.0 1 0 0 1 1 1 1 Exocyst complex component Sec3 Sec3-PIP2_bind PF15277.6 EXF80511.1 - 8.1e-29 99.6 0.0 1.7e-28 98.6 0.0 1.6 1 0 0 1 1 1 1 Exocyst complex component SEC3 N-terminal PIP2 binding PH Sec3_C_2 PF15278.6 EXF80511.1 - 0.012 15.9 0.0 0.037 14.4 0.0 1.8 1 0 0 1 1 1 0 Sec3 exocyst complex subunit Vps52 PF04129.12 EXF80511.1 - 2.2 6.9 8.2 0.054 12.2 0.3 2.1 3 0 0 3 3 3 0 Vps52 / Sac2 family HET PF06985.11 EXF80513.1 - 0.084 13.2 0.5 0.13 12.7 0.5 1.3 1 0 0 1 1 1 0 Heterokaryon incompatibility protein (HET) Chromo_shadow PF01393.19 EXF80514.1 - 2.5e-18 65.9 1.9 2.8e-17 62.5 0.3 2.7 3 0 0 3 3 3 1 Chromo shadow domain Chromo PF00385.24 EXF80514.1 - 1.3e-11 44.2 2.0 1.5e-11 44.0 0.1 2.1 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain zf-Di19 PF05605.12 EXF80515.1 - 0.017 15.4 0.0 0.042 14.1 0.0 1.6 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding bZIP_1 PF00170.21 EXF80515.1 - 0.037 14.1 0.9 0.037 14.1 0.9 1.9 2 0 0 2 2 2 0 bZIP transcription factor zf-C2H2_4 PF13894.6 EXF80515.1 - 0.04 14.7 0.1 0.1 13.5 0.1 1.7 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2HC_2 PF13913.6 EXF80515.1 - 0.057 13.3 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 zinc-finger of a C2HC-type zf-C2H2 PF00096.26 EXF80515.1 - 0.1 13.1 0.1 0.22 12.0 0.1 1.5 1 0 0 1 1 1 0 Zinc finger, C2H2 type HALZ PF02183.18 EXF80515.1 - 0.16 12.2 5.8 0.71 10.1 2.9 2.7 2 0 0 2 2 2 0 Homeobox associated leucine zipper zf-ribbon_3 PF13248.6 EXF80515.1 - 0.18 11.2 0.5 0.4 10.2 0.5 1.5 1 0 0 1 1 1 0 zinc-ribbon domain UPF0242 PF06785.11 EXF80515.1 - 8.2 6.5 23.5 0.016 15.3 3.0 2.4 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus YabA PF06156.13 EXF80515.1 - 9.8 6.9 10.9 0.61 10.8 0.5 3.2 3 0 0 3 3 3 0 Initiation control protein YabA zf-Nse PF11789.8 EXF80516.1 - 1.4e-19 69.6 0.1 6.5e-19 67.5 0.1 2.1 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.6 EXF80516.1 - 2e-06 27.7 0.1 4.1e-06 26.7 0.1 1.6 1 0 0 1 1 1 1 RING-type zinc-finger U-box PF04564.15 EXF80516.1 - 0.00016 21.8 0.0 0.00046 20.3 0.0 1.6 1 1 0 1 1 1 1 U-box domain zf-C3HC4_2 PF13923.6 EXF80516.1 - 0.0014 18.5 0.0 0.0028 17.5 0.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EXF80516.1 - 0.016 15.3 0.1 0.095 12.9 0.1 2.1 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING DUF3106 PF11304.8 EXF80516.1 - 0.024 15.1 1.4 0.62 10.6 0.1 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF3106) zf-rbx1 PF12678.7 EXF80516.1 - 0.03 14.6 0.0 0.066 13.5 0.0 1.5 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-MIZ PF02891.20 EXF80516.1 - 0.22 11.3 1.1 0.28 11.0 0.2 1.7 2 0 0 2 2 2 0 MIZ/SP-RING zinc finger Hexokinase_2 PF03727.16 EXF80517.1 - 1.5e-54 185.0 0.0 3.3e-54 183.9 0.0 1.6 1 1 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 EXF80517.1 - 2.6e-38 132.0 0.0 4.4e-38 131.2 0.0 1.3 1 0 0 1 1 1 1 Hexokinase Glucosamine_iso PF01182.20 EXF80518.1 - 2.6e-20 73.3 0.0 4.7e-20 72.4 0.0 1.4 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase DUF3464 PF11947.8 EXF80518.1 - 0.018 14.8 4.4 1.5 8.6 0.2 2.4 1 1 1 2 2 2 0 Photosynthesis affected mutant 68 NDT80_PhoG PF05224.12 EXF80519.1 - 2.7e-32 112.5 0.0 4.3e-32 111.8 0.0 1.4 1 0 0 1 1 1 1 NDT80 / PhoG like DNA-binding family Amidohydro_1 PF01979.20 EXF80519.1 - 4.7e-15 55.8 0.2 7.4e-15 55.1 0.2 1.3 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EXF80519.1 - 6.4e-09 35.8 0.6 1.1e-07 31.8 0.2 2.6 3 0 0 3 3 3 1 Amidohydrolase family Glyco_hydro_3 PF00933.21 EXF80520.1 - 1.2e-63 215.4 0.0 1.7e-63 214.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.22 EXF80520.1 - 0.0025 17.8 0.0 0.0048 16.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_31 PF01055.26 EXF80521.1 - 4.8e-110 368.8 0.7 5.9e-110 368.5 0.7 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 EXF80521.1 - 7.8e-14 51.7 0.3 7.2e-13 48.7 0.1 2.6 3 0 0 3 3 3 1 Galactose mutarotase-like Glyco_hydro_3 PF00933.21 EXF80522.1 - 2.1e-59 201.5 0.0 3.2e-59 200.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.22 EXF80522.1 - 1.5e-52 178.5 0.1 2.3e-52 177.9 0.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.6 EXF80522.1 - 3.2e-23 81.6 0.4 7.4e-23 80.4 0.4 1.7 1 0 0 1 1 1 1 Fibronectin type III-like domain DUF11 PF01345.18 EXF80522.1 - 0.0077 16.5 0.1 0.025 14.9 0.1 1.8 1 0 0 1 1 1 1 Domain of unknown function DUF11 Sugar-bind PF04198.13 EXF80522.1 - 0.14 11.2 0.0 0.27 10.3 0.0 1.3 1 0 0 1 1 1 0 Putative sugar-binding domain PLRV_ORF5 PF01690.17 EXF80523.1 - 0.044 12.5 10.2 0.085 11.6 0.9 2.8 1 1 2 3 3 3 0 Potato leaf roll virus readthrough protein N2227 PF07942.12 EXF80524.1 - 1.2e-95 319.8 0.0 8e-94 313.8 0.0 2.1 1 1 0 1 1 1 1 N2227-like protein Methyltransf_23 PF13489.6 EXF80524.1 - 0.0034 17.2 0.0 0.0062 16.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF80524.1 - 0.0083 16.9 0.0 0.037 14.8 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF80524.1 - 0.013 16.1 0.0 0.056 14.1 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase domain adh_short_C2 PF13561.6 EXF80525.1 - 1.2e-46 159.1 0.6 1.7e-46 158.7 0.6 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF80525.1 - 8.5e-42 142.8 0.2 8.5e-42 142.8 0.2 1.3 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.10 EXF80525.1 - 5.7e-12 45.9 0.2 1e-11 45.1 0.1 1.5 1 1 0 1 1 1 1 KR domain PemK_toxin PF02452.17 EXF80526.1 - 0.0067 16.8 0.0 0.016 15.6 0.0 1.5 1 1 0 1 1 1 1 PemK-like, MazF-like toxin of type II toxin-antitoxin system DUF5082 PF16888.5 EXF80527.1 - 0.14 12.4 2.2 0.88 9.9 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF5082) DUF745 PF05335.13 EXF80527.1 - 0.58 9.9 1.5 0.72 9.5 0.2 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF745) HIP1_clath_bdg PF16515.5 EXF80527.1 - 7 7.3 9.8 23 5.7 0.1 3.5 3 1 0 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 QRPTase_N PF02749.16 EXF80528.1 - 0.12 12.4 0.0 1.4 9.0 0.1 2.1 2 0 0 2 2 2 0 Quinolinate phosphoribosyl transferase, N-terminal domain zf-C2H2 PF00096.26 EXF80530.1 - 0.31 11.6 1.3 0.5 10.9 0.2 2.0 2 0 0 2 2 2 0 Zinc finger, C2H2 type FOXP-CC PF16159.5 EXF80530.1 - 0.51 11.0 2.7 0.37 11.5 0.5 2.0 2 0 0 2 2 2 0 FOXP coiled-coil domain TAF4 PF05236.14 EXF80530.1 - 1.1 9.0 7.6 0.06 13.1 2.4 1.5 2 0 0 2 2 2 0 Transcription initiation factor TFIID component TAF4 family YabA PF06156.13 EXF80530.1 - 8.1 7.1 6.1 4 8.1 0.2 2.2 1 1 1 2 2 2 0 Initiation control protein YabA AAR2 PF05282.11 EXF80531.1 - 3.2e-51 174.8 0.0 6.3e-51 173.8 0.0 1.4 1 1 0 1 1 1 1 AAR2 protein DEAD PF00270.29 EXF80532.1 - 6.5e-50 169.3 0.0 7.9e-49 165.8 0.0 2.1 1 1 1 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EXF80532.1 - 1.5e-30 105.8 0.0 4.2e-30 104.3 0.1 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EXF80532.1 - 4.7e-05 23.4 0.0 0.00031 20.8 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit UTP25 PF06862.12 EXF80532.1 - 0.0044 15.8 1.2 0.39 9.4 0.0 2.6 3 0 0 3 3 3 2 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 AAA_19 PF13245.6 EXF80532.1 - 0.018 15.4 0.0 9.1 6.6 0.0 2.4 2 0 0 2 2 2 0 AAA domain Helicase_C_2 PF13307.6 EXF80532.1 - 0.019 15.1 0.0 0.032 14.4 0.0 1.3 1 0 0 1 1 1 0 Helicase C-terminal domain DUF2443 PF10398.9 EXF80532.1 - 0.12 12.4 0.3 0.26 11.3 0.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2443) Phos_pyr_kin PF08543.12 EXF80533.1 - 8.7e-86 287.3 1.1 1.5e-85 286.5 1.1 1.4 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase TENA_THI-4 PF03070.16 EXF80533.1 - 1.2e-34 119.9 0.3 2.1e-16 60.4 0.1 2.3 1 1 1 2 2 2 2 TENA/THI-4/PQQC family PfkB PF00294.24 EXF80533.1 - 1.3e-08 34.5 0.1 1e-07 31.6 0.1 2.0 1 1 0 1 1 1 1 pfkB family carbohydrate kinase RICTOR_N PF14664.6 EXF80534.1 - 4e-130 434.2 3.0 1.6e-129 432.2 3.2 1.9 2 0 0 2 2 2 1 Rapamycin-insensitive companion of mTOR, N-term RasGEF_N_2 PF14663.6 EXF80534.1 - 5.2e-38 129.8 0.6 2.5e-33 114.7 0.0 3.9 3 0 0 3 3 3 2 Rapamycin-insensitive companion of mTOR RasGEF_N domain RICTOR_M PF14666.6 EXF80534.1 - 2.4e-37 126.9 0.0 6.9e-34 115.7 0.0 4.3 4 0 0 4 4 4 1 Rapamycin-insensitive companion of mTOR, middle domain RICTOR_V PF14668.6 EXF80534.1 - 8.5e-31 106.0 0.2 1.9e-28 98.5 0.1 4.1 5 0 0 5 5 5 1 Rapamycin-insensitive companion of mTOR, domain 5 HR1 PF02185.16 EXF80534.1 - 2.6e-14 53.1 9.6 8.9e-14 51.4 9.6 2.0 1 0 0 1 1 1 1 Hr1 repeat Uds1 PF15456.6 EXF80534.1 - 0.022 14.9 5.0 0.07 13.3 5.0 1.9 1 0 0 1 1 1 0 Up-regulated During Septation V_ATPase_I PF01496.19 EXF80534.1 - 0.27 9.1 0.7 0.46 8.4 0.7 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Peptidase_M32 PF02074.15 EXF80534.1 - 1.6 7.4 4.0 29 3.3 0.0 2.3 2 0 0 2 2 2 0 Carboxypeptidase Taq (M32) metallopeptidase DUF883 PF05957.13 EXF80534.1 - 6 7.5 6.3 18 6.0 2.1 2.5 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) CENP-K PF11802.8 EXF80534.1 - 8.7 5.8 8.7 3.5 7.1 5.8 1.7 2 0 0 2 2 2 0 Centromere-associated protein K Uricase PF01014.18 EXF80535.1 - 1.4e-77 258.2 0.6 2.7e-40 137.7 0.3 2.0 2 0 0 2 2 2 2 Uricase Ribosomal_L13 PF00572.18 EXF80536.1 - 5.2e-41 139.8 0.0 7.5e-41 139.3 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L13 HMA PF00403.26 EXF80537.1 - 8e-13 48.6 0.1 1.3e-12 48.0 0.1 1.4 1 0 0 1 1 1 1 Heavy-metal-associated domain Sod_Cu PF00080.20 EXF80537.1 - 1.1e-07 32.1 0.0 1.8e-07 31.4 0.0 1.3 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) Chordopox_RPO7 PF05864.12 EXF80537.1 - 0.15 12.3 0.4 2.3 8.5 0.0 2.2 2 0 0 2 2 2 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) TPR_1 PF00515.28 EXF80538.1 - 1.7e-18 65.6 6.4 7.4e-09 35.1 0.0 4.6 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_2 PF07719.17 EXF80538.1 - 4.2e-16 57.7 6.0 1.2e-06 28.2 0.0 4.6 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_12 PF13424.6 EXF80538.1 - 1.7e-11 44.2 0.6 2.9e-07 30.7 0.1 3.0 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 EXF80538.1 - 5.8e-11 41.7 3.2 3e-06 27.0 0.0 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 EXF80538.1 - 6.4e-09 35.9 0.3 0.061 14.0 0.0 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 EXF80538.1 - 3.5e-08 32.9 0.2 9.9e-06 25.2 0.0 3.6 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 EXF80538.1 - 6.9e-08 32.0 1.7 6.4e-06 25.8 0.2 3.7 2 1 1 3 3 3 1 TPR repeat PB1 PF00564.24 EXF80538.1 - 2e-06 27.6 0.1 3.7e-06 26.8 0.1 1.4 1 0 0 1 1 1 1 PB1 domain TPR_9 PF13371.6 EXF80538.1 - 2e-05 24.6 0.1 0.19 11.9 0.0 2.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 EXF80538.1 - 5.8e-05 23.7 0.1 0.0061 17.2 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 EXF80538.1 - 7.8e-05 22.8 0.1 0.15 12.5 0.1 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_10 PF13374.6 EXF80538.1 - 0.00082 19.2 1.1 0.23 11.4 0.0 3.8 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 EXF80538.1 - 0.0037 18.0 0.2 0.18 12.7 0.0 3.3 1 1 2 3 3 3 1 Tetratricopeptide repeat DUF3808 PF10300.9 EXF80538.1 - 0.081 11.7 0.0 0.14 10.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3808) TPR_4 PF07721.14 EXF80538.1 - 0.096 13.4 0.4 46 5.0 0.0 3.8 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 EXF80538.1 - 0.1 13.1 0.0 1.3 9.6 0.0 2.7 2 1 0 2 2 2 0 Tetratricopeptide repeat tRNA-synt_1c PF00749.21 EXF80539.1 - 3e-92 308.9 0.0 4e-92 308.5 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain DnaJ_C PF01556.18 EXF80540.1 - 4.1e-37 127.5 0.1 5.5e-37 127.1 0.1 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EXF80540.1 - 3e-23 81.7 4.6 5.2e-23 80.9 4.6 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 EXF80540.1 - 1.1e-12 48.1 21.2 1.9e-12 47.4 21.2 1.4 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 EXF80540.1 - 0.069 13.1 14.3 0.96 9.5 3.7 2.5 2 0 0 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.19 EXF80540.1 - 2.3 8.3 11.2 5.5 7.0 1.0 2.3 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF1356 PF07092.12 EXF80540.1 - 4.1 6.6 4.8 7.2 5.8 0.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1356) Ribosomal_L32e PF01655.18 EXF80541.1 - 4e-49 165.5 0.8 4e-49 165.5 0.8 1.4 1 1 1 2 2 2 1 Ribosomal protein L32 SH3_1 PF00018.28 EXF80543.1 - 3.5e-05 23.3 0.0 7.2e-05 22.3 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EXF80543.1 - 0.05 13.5 0.0 0.11 12.4 0.0 1.6 1 0 0 1 1 1 0 Variant SH3 domain Crystall_4 PF17945.1 EXF80543.1 - 0.1 13.1 0.1 0.44 11.0 0.0 2.0 2 0 0 2 2 2 0 Beta/Gamma crystallin AGH PF17558.2 EXF80543.1 - 2.4 8.3 6.3 2 8.6 1.3 3.2 3 0 0 3 3 3 0 Androgenic gland hormone Bac_rhamnosid6H PF17389.2 EXF80544.1 - 3.9e-12 46.1 0.1 8.3e-12 45.0 0.0 1.5 2 0 0 2 2 2 1 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain Bac_rhamnosid_C PF17390.2 EXF80544.1 - 1.8e-07 30.9 1.3 3.5e-07 29.9 1.3 1.5 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase C-terminal domain GDE_C PF06202.14 EXF80544.1 - 1.7e-06 27.3 0.0 2.4e-06 26.7 0.0 1.2 1 0 0 1 1 1 1 Amylo-alpha-1,6-glucosidase DUF608 PF04685.13 EXF80544.1 - 0.011 14.9 0.1 0.018 14.2 0.1 1.3 1 0 0 1 1 1 0 Glycosyl-hydrolase family 116, catalytic region Glyco_hydro_36 PF17167.4 EXF80544.1 - 0.12 11.1 0.5 0.33 9.6 0.5 1.6 1 1 0 1 1 1 0 Glycosyl hydrolase 36 superfamily, catalytic domain Ig_6 PF18452.1 EXF80545.1 - 0.028 14.0 0.7 0.041 13.5 0.7 1.2 1 0 0 1 1 1 0 Immunoglobulin domain Colipase PF01114.18 EXF80545.1 - 0.085 12.5 2.3 0.16 11.6 2.3 1.5 1 0 0 1 1 1 0 Colipase, N-terminal domain Aminotran_1_2 PF00155.21 EXF80546.1 - 3.6e-60 204.0 0.0 4.8e-60 203.6 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II AMP-binding PF00501.28 EXF80547.1 - 2.8e-43 148.1 0.0 3.8e-43 147.6 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme ACAS_N PF16177.5 EXF80547.1 - 6.9e-11 41.9 1.1 1.6e-10 40.7 0.1 2.1 2 0 0 2 2 2 1 Acetyl-coenzyme A synthetase N-terminus AMP-binding_C PF13193.6 EXF80547.1 - 0.00022 22.2 0.5 0.00072 20.5 0.2 1.9 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain ELFV_dehydrog PF00208.21 EXF80548.1 - 3.4e-65 220.2 0.0 5.3e-65 219.5 0.0 1.3 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Bac_GDH PF05088.12 EXF80548.1 - 2.9e-17 61.6 0.0 1.4e-12 46.1 0.0 2.5 2 1 0 3 3 3 2 Bacterial NAD-glutamate dehydrogenase ELFV_dehydrog_N PF02812.18 EXF80548.1 - 0.0036 17.2 0.0 0.021 14.7 0.0 2.1 2 0 0 2 2 2 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain Aldose_epim PF01263.20 EXF80550.1 - 4.2e-49 167.5 0.4 5.6e-49 167.1 0.4 1.2 1 0 0 1 1 1 1 Aldose 1-epimerase Abhydrolase_6 PF12697.7 EXF80552.1 - 8.3e-06 26.6 2.6 1.5e-05 25.7 2.6 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EXF80552.1 - 0.00052 19.3 0.1 0.0013 18.1 0.1 1.6 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EXF80552.1 - 0.01 15.5 0.5 0.023 14.4 0.5 1.6 1 1 0 1 1 1 0 alpha/beta hydrolase fold TAF4 PF05236.14 EXF80553.1 - 3.8e-25 89.2 8.2 1.7e-21 77.2 6.6 2.2 2 0 0 2 2 2 2 Transcription initiation factor TFIID component TAF4 family CPSF73-100_C PF11718.8 EXF80554.1 - 1.3e-83 279.8 0.0 1.9e-83 279.3 0.0 1.3 1 0 0 1 1 1 1 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term Beta-Casp PF10996.8 EXF80554.1 - 1.1e-29 102.9 0.0 3e-29 101.5 0.0 1.7 2 0 0 2 2 2 1 Beta-Casp domain Lactamase_B PF00753.27 EXF80554.1 - 1.2e-18 67.9 0.5 2.4e-18 66.8 0.5 1.6 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_6 PF16661.5 EXF80554.1 - 9.9e-18 64.3 0.0 1.6e-17 63.6 0.0 1.3 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain RMMBL PF07521.12 EXF80554.1 - 5.1e-12 45.5 0.0 1.2e-11 44.4 0.0 1.5 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B_3 PF13483.6 EXF80554.1 - 9.7e-06 25.6 1.2 1.6e-05 24.9 0.0 1.9 2 1 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B_2 PF12706.7 EXF80554.1 - 1.5e-05 24.6 0.5 3.6e-05 23.4 0.5 1.6 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Beta_lactamase3 PF17030.5 EXF80554.1 - 0.11 11.7 0.0 0.19 10.9 0.0 1.2 1 0 0 1 1 1 0 Putative beta-lactamase-like family V_ATPase_I PF01496.19 EXF80555.1 - 0 1045.2 0.0 0 1045.0 0.0 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family CheZ PF04344.13 EXF80555.1 - 0.024 14.6 2.3 0.6 10.0 0.1 2.3 2 0 0 2 2 2 0 Chemotaxis phosphatase, CheZ SesA PF17107.5 EXF80555.1 - 0.093 12.9 1.5 0.99 9.6 0.1 2.7 3 0 0 3 3 3 0 N-terminal domain on NACHT_NTPase and P-loop NTPases DUF1515 PF07439.11 EXF80555.1 - 0.16 12.0 0.6 0.71 9.9 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1515) Snapin_Pallidin PF14712.6 EXF80555.1 - 1.1 9.8 4.2 27 5.3 0.8 2.7 2 1 0 2 2 2 0 Snapin/Pallidin DUF3552 PF12072.8 EXF80555.1 - 1.1 8.6 4.3 9.4 5.6 0.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3552) CHD5 PF04420.14 EXF80556.1 - 3e-60 202.7 3.1 4.2e-60 202.2 3.1 1.2 1 0 0 1 1 1 1 CHD5-like protein PcfJ PF14284.6 EXF80556.1 - 0.1 12.5 0.1 0.14 12.0 0.1 1.2 1 0 0 1 1 1 0 PcfJ-like protein Peptidase_S49_N PF08496.10 EXF80556.1 - 1 9.4 5.4 0.098 12.7 0.4 1.8 2 1 0 2 2 2 0 Peptidase family S49 N-terminal PPTA PF01239.22 EXF80557.1 - 5e-06 26.1 12.9 0.0041 16.8 0.2 3.8 3 0 0 3 3 3 2 Protein prenyltransferase alpha subunit repeat Asp PF00026.23 EXF80558.1 - 4.9e-66 223.3 5.5 6.4e-66 222.9 5.5 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EXF80558.1 - 5.9e-10 39.7 5.9 2.1e-05 24.8 0.2 2.9 2 1 1 3 3 3 2 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EXF80558.1 - 0.0035 18.0 0.0 0.12 13.1 0.0 3.1 2 1 0 2 2 2 1 Aspartyl protease TAXi_C PF14541.6 EXF80558.1 - 0.11 12.3 0.0 0.23 11.2 0.0 1.7 1 0 0 1 1 1 0 Xylanase inhibitor C-terminal Aa_trans PF01490.18 EXF80559.1 - 5e-73 246.2 35.3 5.8e-73 245.9 35.3 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein MWFE PF15879.5 EXF80559.1 - 0.25 11.5 0.5 14 5.9 0.2 3.1 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase MWFE subunit Fungal_trans PF04082.18 EXF80560.1 - 3.3e-19 69.0 0.0 5e-19 68.4 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF80560.1 - 0.00014 21.9 8.1 0.00022 21.3 8.1 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Lar_restr_allev PF14354.6 EXF80560.1 - 0.57 10.6 3.4 1.1 9.6 3.4 1.5 1 0 0 1 1 1 0 Restriction alleviation protein Lar CT_A_B PF02626.15 EXF80561.1 - 4.8e-87 291.9 0.0 9.1e-87 291.0 0.0 1.5 1 0 0 1 1 1 1 Carboxyltransferase domain, subdomain A and B Amidase PF01425.21 EXF80561.1 - 4.2e-86 289.7 0.0 6.8e-86 289.0 0.0 1.3 1 0 0 1 1 1 1 Amidase CPSase_L_D2 PF02786.17 EXF80561.1 - 7.5e-65 218.4 0.1 1.2e-64 217.7 0.1 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 EXF80561.1 - 2.5e-40 137.5 0.2 6.7e-40 136.1 0.1 1.9 2 0 0 2 2 2 1 Biotin carboxylase, N-terminal domain CT_C_D PF02682.16 EXF80561.1 - 2.5e-38 131.9 0.0 5.2e-38 130.8 0.0 1.5 1 0 0 1 1 1 1 Carboxyltransferase domain, subdomain C and D Biotin_carb_C PF02785.19 EXF80561.1 - 1.3e-32 112.1 0.0 2.8e-32 111.0 0.0 1.6 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain Dala_Dala_lig_C PF07478.13 EXF80561.1 - 4.4e-11 42.7 0.0 7.7e-11 41.9 0.0 1.3 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus Biotin_lipoyl PF00364.22 EXF80561.1 - 9.3e-11 41.4 1.4 2e-10 40.3 1.4 1.6 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 EXF80561.1 - 9.9e-05 22.1 0.0 0.63 9.9 0.2 2.7 1 1 1 2 2 2 2 Biotin-lipoyl like ATP-grasp_3 PF02655.14 EXF80561.1 - 0.013 15.5 0.0 0.031 14.3 0.0 1.6 1 0 0 1 1 1 0 ATP-grasp domain GCV_H PF01597.19 EXF80561.1 - 0.078 12.9 0.1 0.17 11.7 0.1 1.5 1 0 0 1 1 1 0 Glycine cleavage H-protein C2 PF00168.30 EXF80563.1 - 1.1e-27 96.3 0.0 4.3e-15 55.8 0.0 2.5 2 0 0 2 2 2 2 C2 domain Oxidored_FMN PF00724.20 EXF80564.1 - 3.4e-66 223.9 0.0 3.9e-66 223.6 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Dus PF01207.17 EXF80564.1 - 0.058 12.5 0.0 0.14 11.3 0.0 1.5 1 0 0 1 1 1 0 Dihydrouridine synthase (Dus) Plant_NMP1 PF06694.11 EXF80564.1 - 0.071 12.2 0.0 0.28 10.3 0.0 1.7 1 1 0 2 2 2 0 Plant nuclear matrix protein 1 (NMP1) DAO PF01266.24 EXF80565.1 - 1.6e-35 123.3 0.2 1.9e-35 123.1 0.2 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EXF80565.1 - 0.00013 22.0 0.1 0.17 11.9 0.0 2.3 2 0 0 2 2 2 2 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 EXF80565.1 - 0.0014 17.9 0.0 0.56 9.4 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.18 EXF80565.1 - 0.0017 18.6 0.0 0.0049 17.1 0.0 1.8 1 0 0 1 1 1 1 TrkA-N domain Sacchrp_dh_NADP PF03435.18 EXF80565.1 - 0.0021 18.3 0.1 0.0042 17.4 0.1 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_8 PF13450.6 EXF80565.1 - 0.0029 17.8 0.0 0.0069 16.6 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EXF80565.1 - 0.021 13.9 0.3 0.084 11.9 0.0 1.9 2 0 0 2 2 2 0 FAD binding domain Trp_halogenase PF04820.14 EXF80565.1 - 0.06 12.2 0.3 5.7 5.7 0.0 2.1 2 0 0 2 2 2 0 Tryptophan halogenase Sulfatase PF00884.23 EXF80566.1 - 2.8e-59 201.0 0.0 4.1e-59 200.5 0.0 1.2 1 0 0 1 1 1 1 Sulfatase Sulfatase_C PF14707.6 EXF80566.1 - 2.1e-05 25.2 0.0 5e-05 24.0 0.0 1.6 1 0 0 1 1 1 1 C-terminal region of aryl-sulfatase Phosphodiest PF01663.22 EXF80566.1 - 0.0043 16.7 0.1 0.25 10.9 0.0 2.1 2 0 0 2 2 2 1 Type I phosphodiesterase / nucleotide pyrophosphatase VSP PF03302.13 EXF80566.1 - 0.0047 15.8 2.3 0.0047 15.8 2.3 1.5 2 0 0 2 2 2 1 Giardia variant-specific surface protein CYYR1 PF10873.8 EXF80566.1 - 0.015 15.8 0.8 0.039 14.4 0.0 2.0 2 0 0 2 2 2 0 Cysteine and tyrosine-rich protein 1 Adeno_E3_CR2 PF02439.15 EXF80566.1 - 0.2 11.4 0.2 0.42 10.4 0.2 1.5 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 NUC173 PF08161.12 EXF80567.1 - 4.8e-81 271.3 2.8 2.5e-78 262.4 0.2 3.6 3 0 0 3 3 3 2 NUC173 domain HEAT_2 PF13646.6 EXF80567.1 - 0.0083 16.5 3.6 2.9 8.3 0.2 4.8 4 0 0 4 4 4 1 HEAT repeats DinB_2 PF12867.7 EXF80567.1 - 0.024 15.1 0.2 0.26 11.8 0.0 2.8 3 0 0 3 3 3 0 DinB superfamily HEAT PF02985.22 EXF80567.1 - 0.042 14.1 1.1 4.5 7.8 0.0 4.1 4 0 0 4 4 4 0 HEAT repeat TFCD_C PF12612.8 EXF80567.1 - 0.073 12.9 3.4 7.4 6.4 0.0 4.9 5 2 1 6 6 6 0 Tubulin folding cofactor D C terminal CdiI_2 PF18593.1 EXF80567.1 - 0.13 12.9 0.0 17 6.2 0.0 3.5 3 0 0 3 3 3 0 CdiI immunity protein V-SNARE PF05008.15 EXF80568.1 - 1.7e-19 70.0 1.3 1.7e-19 70.0 1.3 1.8 2 0 0 2 2 2 1 Vesicle transport v-SNARE protein N-terminus V-SNARE_C PF12352.8 EXF80568.1 - 2.4e-19 69.4 1.9 2.4e-19 69.4 1.9 2.1 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 EXF80568.1 - 0.019 14.9 0.9 0.048 13.6 0.3 2.0 2 1 1 3 3 3 0 Sec20 FAM76 PF16046.5 EXF80568.1 - 0.036 13.4 0.1 0.056 12.8 0.1 1.3 1 0 0 1 1 1 0 FAM76 protein Fusion_gly PF00523.18 EXF80568.1 - 0.098 10.9 1.9 0.12 10.5 0.6 1.7 2 0 0 2 2 2 0 Fusion glycoprotein F0 Spectrin PF00435.21 EXF80568.1 - 0.13 12.7 2.2 0.36 11.3 0.3 2.4 2 1 1 3 3 3 0 Spectrin repeat SNARE PF05739.19 EXF80568.1 - 0.28 11.2 2.2 0.31 11.1 0.5 2.0 2 0 0 2 2 2 0 SNARE domain Exonuc_VII_L PF02601.15 EXF80568.1 - 0.43 10.1 5.3 0.69 9.4 5.3 1.4 1 1 0 1 1 1 0 Exonuclease VII, large subunit PRA1 PF03208.19 EXF80569.1 - 1.3e-07 31.4 2.6 2.1e-07 30.7 2.6 1.2 1 0 0 1 1 1 1 PRA1 family protein FA_desaturase PF00487.24 EXF80569.1 - 0.16 11.8 3.0 0.28 11.0 3.0 1.4 1 0 0 1 1 1 0 Fatty acid desaturase DUF755 PF05501.11 EXF80569.1 - 6.9 7.0 13.1 2.3 8.5 7.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF755) Amino_oxidase PF01593.24 EXF80570.1 - 3.1e-19 69.6 0.0 1.7e-14 54.0 0.0 2.4 2 1 0 2 2 2 2 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EXF80570.1 - 1e-10 41.7 0.1 2.3e-10 40.6 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EXF80570.1 - 1.7e-06 27.5 0.1 0.00047 19.5 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EXF80570.1 - 2.4e-05 24.3 0.1 0.11 12.5 0.0 2.7 2 1 0 2 2 2 2 FAD-NAD(P)-binding DAO PF01266.24 EXF80570.1 - 9.3e-05 22.2 0.1 0.015 14.9 0.1 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase HI0933_like PF03486.14 EXF80570.1 - 0.00015 20.6 0.1 0.075 11.7 0.0 2.2 2 0 0 2 2 2 2 HI0933-like protein Pyr_redox_3 PF13738.6 EXF80570.1 - 0.0035 16.7 0.0 0.34 10.1 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EXF80570.1 - 0.02 14.0 0.2 0.034 13.2 0.2 1.3 1 0 0 1 1 1 0 FAD binding domain FAD_oxidored PF12831.7 EXF80570.1 - 0.022 14.1 0.0 0.035 13.5 0.0 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase Pyr_redox PF00070.27 EXF80570.1 - 0.053 14.1 0.1 5 7.8 0.1 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase CtaG_Cox11 PF04442.14 EXF80571.1 - 1.6e-59 200.3 0.0 2.6e-59 199.6 0.0 1.3 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein CtaG/Cox11 Ribosomal_L26 PF16906.5 EXF80572.1 - 1.6e-37 127.8 1.6 2.1e-37 127.4 1.6 1.1 1 0 0 1 1 1 1 Ribosomal proteins L26 eukaryotic, L24P archaeal KOW PF00467.29 EXF80572.1 - 1.1e-07 31.5 1.8 2.5e-07 30.4 1.8 1.6 1 0 0 1 1 1 1 KOW motif DUF1223 PF06764.11 EXF80572.1 - 0.017 15.2 0.1 0.019 15.0 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1223) SET PF00856.28 EXF80574.1 - 0.015 15.7 0.1 0.064 13.6 0.0 1.9 2 0 0 2 2 2 0 SET domain VSP PF03302.13 EXF80576.1 - 9e-06 24.8 0.5 1.4e-05 24.2 0.1 1.5 2 0 0 2 2 2 1 Giardia variant-specific surface protein SKG6 PF08693.10 EXF80576.1 - 0.0016 17.8 0.1 0.0034 16.7 0.1 1.6 1 0 0 1 1 1 1 Transmembrane alpha-helix domain DUF347 PF03988.12 EXF80576.1 - 0.0064 16.7 0.4 0.015 15.4 0.4 1.6 1 0 0 1 1 1 1 Repeat of Unknown Function (DUF347) DUF4448 PF14610.6 EXF80576.1 - 0.019 14.8 0.0 0.046 13.5 0.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF4448) NICE-1 PF15845.5 EXF80576.1 - 0.034 14.9 1.2 0.062 14.1 1.2 1.4 1 0 0 1 1 1 0 Cysteine-rich C-terminal 1 family GPI-anchored PF10342.9 EXF80576.1 - 0.095 13.5 0.6 0.17 12.7 0.6 1.4 1 0 0 1 1 1 0 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family LapA_dom PF06305.11 EXF80576.1 - 0.23 11.3 0.1 0.48 10.3 0.1 1.5 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain Ala_racemase_N PF01168.20 EXF80577.1 - 9e-21 74.5 0.1 1.1e-20 74.3 0.1 1.0 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain Thioredoxin_8 PF13905.6 EXF80577.1 - 0.17 12.2 0.0 0.29 11.5 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin-like Zn_clus PF00172.18 EXF80578.1 - 6.1e-08 32.6 12.2 9.9e-08 32.0 12.2 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ANAPC2 PF08672.11 EXF80578.1 - 0.034 14.6 0.0 0.096 13.2 0.0 1.7 1 0 0 1 1 1 0 Anaphase promoting complex (APC) subunit 2 HMGL-like PF00682.19 EXF80580.1 - 3.7e-40 138.1 0.0 1.3e-39 136.3 0.0 1.7 1 1 0 1 1 1 1 HMGL-like ATP-synt_ab PF00006.25 EXF80581.1 - 2.2e-65 220.3 0.0 3.9e-65 219.5 0.0 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 EXF80581.1 - 7.7e-15 55.2 0.9 1.6e-14 54.2 0.9 1.6 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain DUF5535 PF17687.1 EXF80581.1 - 0.15 12.3 0.0 0.35 11.1 0.0 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5535) DUF561 PF04481.12 EXF80581.1 - 0.17 11.0 0.0 0.27 10.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF561) P16-Arc PF04699.14 EXF80582.1 - 1.2e-48 165.4 0.0 1.4e-48 165.2 0.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex 16 kDa subunit (p16-Arc) DUF2605 PF10792.9 EXF80582.1 - 0.16 11.9 0.0 0.36 10.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2605) Methyltransf_11 PF08241.12 EXF80583.1 - 2.8e-09 37.5 0.0 7.1e-09 36.2 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EXF80583.1 - 5.3e-09 36.1 0.0 1.3e-08 34.9 0.0 1.6 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF80583.1 - 8.9e-07 29.6 0.0 1.6e-06 28.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF80583.1 - 8.3e-06 26.4 0.0 2.1e-05 25.1 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF80583.1 - 0.0024 17.7 0.0 0.0058 16.4 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Adaptin_N PF01602.20 EXF80584.1 - 3.6e-123 411.9 10.3 4.7e-123 411.5 10.3 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptin_C PF02296.16 EXF80584.1 - 4.9e-46 155.6 0.0 1.4e-45 154.1 0.0 1.8 1 0 0 1 1 1 1 Alpha adaptin AP2, C-terminal domain Alpha_adaptinC2 PF02883.20 EXF80584.1 - 4.3e-15 56.0 0.0 7.8e-15 55.1 0.0 1.5 1 0 0 1 1 1 1 Adaptin C-terminal domain Proteasom_PSMB PF10508.9 EXF80584.1 - 0.013 14.1 5.4 0.13 10.8 1.9 2.3 2 0 0 2 2 2 0 Proteasome non-ATPase 26S subunit BAG6 PF12057.8 EXF80585.1 - 0.031 14.0 0.0 0.065 12.9 0.0 1.5 1 0 0 1 1 1 0 BCL2-associated athanogene 6 zf-C2H2_2 PF12756.7 EXF80586.1 - 0.0084 16.4 2.2 0.026 14.9 2.2 1.8 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.26 EXF80586.1 - 0.033 14.6 0.6 0.033 14.6 0.6 3.0 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EXF80586.1 - 0.048 14.5 14.4 0.3 12.0 1.1 3.4 3 0 0 3 3 3 0 C2H2-type zinc finger Regnase_1_C PF18561.1 EXF80586.1 - 0.12 12.2 0.1 1.3 8.8 0.0 2.6 3 0 0 3 3 3 0 Endoribonuclease Regnase 1/ ZC3H12 C-terminal domain zf-met PF12874.7 EXF80586.1 - 0.21 12.1 4.7 3.5 8.2 0.6 2.7 2 0 0 2 2 2 0 Zinc-finger of C2H2 type Med19 PF10278.9 EXF80586.1 - 0.23 11.4 5.0 0.47 10.4 5.0 1.5 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 RNA_pol_Rpc4 PF05132.14 EXF80586.1 - 0.45 10.9 6.1 0.99 9.8 6.1 1.5 1 0 0 1 1 1 0 RNA polymerase III RPC4 MRNIP PF15749.5 EXF80586.1 - 0.78 10.5 8.1 2.9 8.7 7.7 2.2 1 1 0 1 1 1 0 MRN-interacting protein Paramyxo_ncap PF00973.19 EXF80586.1 - 1.1 8.0 4.2 2 7.2 4.2 1.3 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein zf-Di19 PF05605.12 EXF80586.1 - 3.8 7.9 7.2 5.2 7.4 0.2 2.7 3 0 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding CLTH PF10607.9 EXF80587.1 - 0.12 12.3 0.6 0.47 10.3 0.2 2.1 2 0 0 2 2 2 0 CTLH/CRA C-terminal to LisH motif domain zf-Di19 PF05605.12 EXF80588.1 - 0.00072 19.8 7.6 0.37 11.1 0.2 3.4 3 0 0 3 3 3 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.6 EXF80588.1 - 0.00073 20.2 12.0 0.12 13.3 0.4 4.7 4 0 0 4 4 4 1 C2H2-type zinc finger zf-C2H2_2 PF12756.7 EXF80588.1 - 0.0054 17.0 6.5 0.13 12.6 0.1 3.6 1 1 2 3 3 3 1 C2H2 type zinc-finger (2 copies) BIR PF00653.21 EXF80588.1 - 0.021 15.5 0.8 5.2 7.8 0.4 2.6 2 0 0 2 2 2 0 Inhibitor of Apoptosis domain zf-nanos PF05741.13 EXF80588.1 - 0.043 14.0 6.7 0.75 10.1 0.2 3.8 2 1 0 2 2 2 0 Nanos RNA binding domain zf-C2H2 PF00096.26 EXF80588.1 - 0.055 14.0 12.8 3.6 8.2 0.0 4.7 4 0 0 4 4 4 0 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 EXF80588.1 - 0.12 12.7 0.1 0.12 12.7 0.1 2.9 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.6 EXF80588.1 - 0.12 12.9 6.3 7.2 7.2 0.2 3.8 3 0 0 3 3 3 0 Zinc-finger double domain zf-met PF12874.7 EXF80588.1 - 0.41 11.1 0.1 0.41 11.1 0.1 2.5 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-LITAF-like PF10601.9 EXF80588.1 - 0.44 10.8 2.5 6.6 7.1 0.1 2.4 2 0 0 2 2 2 0 LITAF-like zinc ribbon domain CpXC PF14353.6 EXF80588.1 - 7 6.7 8.1 3.7 7.6 0.1 3.3 2 2 0 3 3 3 0 CpXC protein NPP1 PF05630.11 EXF80590.1 - 3.8e-66 223.0 0.0 4.3e-66 222.8 0.0 1.0 1 0 0 1 1 1 1 Necrosis inducing protein (NPP1) Fungal_trans PF04082.18 EXF80591.1 - 6.2e-12 45.1 0.8 1.3e-11 44.0 0.8 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF80591.1 - 6.8e-08 32.5 8.2 1.5e-07 31.4 8.2 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Phosphoesterase PF04185.14 EXF80592.1 - 4.6e-22 78.7 0.7 1e-20 74.3 0.7 2.1 1 1 0 1 1 1 1 Phosphoesterase family PTS_IIA PF02255.16 EXF80593.1 - 0.58 10.2 1.8 1 9.4 1.8 1.4 1 0 0 1 1 1 0 PTS system, Lactose/Cellobiose specific IIA subunit ApbA_C PF08546.11 EXF80594.1 - 8.3e-25 87.4 0.0 1.4e-24 86.6 0.0 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.16 EXF80594.1 - 2.3e-24 85.8 0.0 3.2e-24 85.3 0.0 1.2 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA ThiF PF00899.21 EXF80594.1 - 0.0038 16.6 4.1 0.0072 15.7 3.3 1.8 1 1 1 2 2 2 1 ThiF family IlvN PF07991.12 EXF80594.1 - 0.057 13.0 0.1 2.1 7.9 0.0 2.2 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain DUF2470 PF10615.9 EXF80595.1 - 1.5e-18 67.2 0.0 2.1e-18 66.7 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2470) COesterase PF00135.28 EXF80596.1 - 1.7e-81 274.7 0.0 6.1e-75 253.0 0.0 2.0 1 1 1 2 2 2 2 Carboxylesterase family Abhydrolase_3 PF07859.13 EXF80596.1 - 3.7e-13 49.8 0.0 5.8e-13 49.2 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold zf-C2H2_4 PF13894.6 EXF80597.1 - 0.19 12.7 0.2 0.19 12.7 0.2 2.3 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EXF80597.1 - 0.25 11.4 0.1 0.25 11.4 0.1 2.1 2 0 0 2 2 2 0 C2H2-type zinc finger ADH_N PF08240.12 EXF80598.1 - 6.9e-16 58.1 0.2 3e-15 56.0 0.2 2.0 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EXF80598.1 - 2.5e-09 37.2 0.0 1.2e-08 35.0 0.0 2.0 1 1 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EXF80598.1 - 1.3e-05 24.8 0.1 3.5e-05 23.4 0.1 1.7 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus AlaDh_PNT_C PF01262.21 EXF80598.1 - 0.00014 21.3 0.0 0.00021 20.6 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain HI0933_like PF03486.14 EXF80598.1 - 0.037 12.7 0.0 0.047 12.4 0.0 1.1 1 0 0 1 1 1 0 HI0933-like protein FAD_binding_3 PF01494.19 EXF80598.1 - 0.073 12.3 0.1 0.1 11.8 0.1 1.1 1 0 0 1 1 1 0 FAD binding domain FAD_binding_2 PF00890.24 EXF80598.1 - 0.08 12.0 0.1 0.08 12.0 0.1 1.7 2 0 0 2 2 2 0 FAD binding domain Pyr_redox_3 PF13738.6 EXF80598.1 - 0.097 11.9 0.1 0.21 10.8 0.0 1.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase COesterase PF00135.28 EXF80599.1 - 8.7e-77 259.1 0.0 3.7e-72 243.9 0.0 2.0 1 1 1 2 2 2 2 Carboxylesterase family Abhydrolase_3 PF07859.13 EXF80599.1 - 2.3e-14 53.8 0.2 3.6e-14 53.1 0.2 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Esterase_phd PF10503.9 EXF80599.1 - 0.0093 15.5 0.0 0.02 14.4 0.0 1.5 1 0 0 1 1 1 1 Esterase PHB depolymerase DUF1614 PF07758.11 EXF80600.1 - 0.074 13.0 0.6 3.5 7.6 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1614) Glyco_hydro_61 PF03443.14 EXF80602.1 - 1.9e-66 223.9 0.1 2.3e-66 223.7 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 NPCBM_assoc PF10633.9 EXF80602.1 - 0.0024 18.1 0.1 2.9 8.2 0.0 2.6 2 0 0 2 2 2 2 NPCBM-associated, NEW3 domain of alpha-galactosidase CSD PF00313.22 EXF80602.1 - 0.18 11.7 0.0 0.35 10.8 0.0 1.4 1 0 0 1 1 1 0 'Cold-shock' DNA-binding domain Peptidase_M35 PF02102.15 EXF80603.1 - 5e-83 278.9 18.9 6.1e-83 278.7 18.9 1.0 1 0 0 1 1 1 1 Deuterolysin metalloprotease (M35) family Aspzincin_M35 PF14521.6 EXF80603.1 - 5.2e-43 147.1 7.5 5.2e-43 147.1 7.5 1.7 1 1 0 2 2 2 1 Lysine-specific metallo-endopeptidase COesterase PF00135.28 EXF80604.1 - 9.6e-80 268.9 1.9 8.6e-79 265.7 1.9 1.9 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EXF80604.1 - 1.2e-05 25.3 0.1 3.4e-05 23.8 0.1 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EXF80604.1 - 0.0083 15.6 0.1 0.0083 15.6 0.1 2.0 2 1 0 2 2 2 1 Prolyl oligopeptidase family AIRS PF00586.24 EXF80604.1 - 0.1 13.3 0.0 0.35 11.5 0.0 1.9 2 0 0 2 2 2 0 AIR synthase related protein, N-terminal domain Glyco_hydro_47 PF01532.20 EXF80605.1 - 4.7e-136 454.3 0.0 9.8e-116 387.3 0.0 2.0 2 0 0 2 2 2 2 Glycosyl hydrolase family 47 Sulfotransfer_4 PF17784.1 EXF80607.1 - 1.6e-60 204.6 0.0 2e-60 204.3 0.0 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 EXF80607.1 - 0.0045 17.4 0.1 0.019 15.3 0.0 2.0 2 1 0 2 2 2 1 Sulfotransferase family ketoacyl-synt PF00109.26 EXF80608.1 - 1.2e-70 238.0 0.0 2.3e-70 237.1 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.10 EXF80608.1 - 5e-55 186.2 0.0 1.7e-54 184.5 0.0 2.0 1 0 0 1 1 1 1 KR domain PS-DH PF14765.6 EXF80608.1 - 4e-54 183.9 0.0 8.2e-54 182.8 0.0 1.6 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 EXF80608.1 - 4.7e-47 161.0 0.0 7.8e-47 160.3 0.0 1.4 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EXF80608.1 - 1.4e-37 128.3 0.1 4.1e-37 126.8 0.1 1.9 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Methyltransf_12 PF08242.12 EXF80608.1 - 1.2e-21 77.2 0.0 7.4e-21 74.7 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain ADH_zinc_N_2 PF13602.6 EXF80608.1 - 4.5e-19 69.8 0.0 1.7e-17 64.8 0.0 2.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 EXF80608.1 - 6e-17 61.8 2.0 1.1e-15 57.7 0.0 3.7 4 0 0 4 4 4 1 Zinc-binding dehydrogenase Methyltransf_25 PF13649.6 EXF80608.1 - 3.6e-14 53.2 0.0 2.3e-13 50.7 0.0 2.6 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EXF80608.1 - 6.7e-14 52.1 0.0 1.6e-13 50.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain KAsynt_C_assoc PF16197.5 EXF80608.1 - 1.5e-13 51.2 0.0 7.1e-13 49.0 0.0 2.2 1 1 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Methyltransf_31 PF13847.6 EXF80608.1 - 5.7e-12 45.7 0.0 1.6e-11 44.2 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF80608.1 - 3.2e-11 43.7 0.0 1.3e-10 41.8 0.0 2.2 1 0 0 1 1 1 1 Methyltransferase domain PP-binding PF00550.25 EXF80608.1 - 4.9e-08 33.2 0.0 1.5e-07 31.7 0.0 1.9 1 0 0 1 1 1 1 Phosphopantetheine attachment site adh_short PF00106.25 EXF80608.1 - 1.6e-06 27.7 4.2 8.7e-06 25.3 0.0 3.1 3 0 0 3 3 3 1 short chain dehydrogenase Thiolase_N PF00108.23 EXF80608.1 - 1.9e-06 27.4 0.1 4.4e-06 26.3 0.1 1.5 1 0 0 1 1 1 1 Thiolase, N-terminal domain Ubie_methyltran PF01209.18 EXF80608.1 - 5.7e-05 22.6 0.0 0.00015 21.2 0.0 1.6 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family DUF938 PF06080.12 EXF80608.1 - 6.1e-05 22.9 0.0 0.00017 21.4 0.0 1.7 2 0 0 2 2 1 1 Protein of unknown function (DUF938) ADH_N PF08240.12 EXF80608.1 - 8.9e-05 22.3 0.0 0.00028 20.8 0.0 1.9 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain adh_short_C2 PF13561.6 EXF80608.1 - 0.00062 19.4 0.2 0.0065 16.0 0.0 2.5 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase Methyltransf_28 PF02636.17 EXF80608.1 - 0.0026 17.4 0.0 0.0056 16.3 0.0 1.5 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_33 PF10017.9 EXF80608.1 - 0.015 14.5 0.0 0.034 13.3 0.0 1.5 1 0 0 1 1 1 0 Histidine-specific methyltransferase, SAM-dependent Methyltransf_16 PF10294.9 EXF80608.1 - 0.017 14.9 0.0 0.038 13.7 0.0 1.5 1 0 0 1 1 1 0 Lysine methyltransferase Methyltransf_24 PF13578.6 EXF80608.1 - 0.026 15.5 0.0 0.083 13.9 0.0 2.0 1 0 0 1 1 1 0 Methyltransferase domain ACP_syn_III PF08545.10 EXF80608.1 - 0.04 13.8 0.3 0.12 12.3 0.3 1.8 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III PHC2_SAM_assoc PF16616.5 EXF80608.1 - 0.18 12.7 0.8 0.52 11.1 0.8 1.8 1 0 0 1 1 1 0 Unstructured region on Polyhomeotic-like protein 1 and 2 DREV PF05219.12 EXF80608.1 - 0.19 10.8 0.0 0.43 9.6 0.0 1.5 1 0 0 1 1 1 0 DREV methyltransferase FAD_binding_4 PF01565.23 EXF80609.1 - 1.2e-21 76.9 0.3 5.7e-20 71.5 0.1 2.8 2 1 0 2 2 2 1 FAD binding domain BBE PF08031.12 EXF80609.1 - 3.7e-05 23.8 0.0 9.9e-05 22.4 0.0 1.8 1 0 0 1 1 1 1 Berberine and berberine like p450 PF00067.22 EXF80610.1 - 3.6e-62 210.6 0.0 4.5e-62 210.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 CDI PF02234.19 EXF80610.1 - 0.047 13.9 0.2 0.14 12.4 0.2 1.8 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor p450 PF00067.22 EXF80611.1 - 3.9e-55 187.4 0.0 6.2e-55 186.8 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 Aldedh PF00171.22 EXF80612.1 - 3.2e-186 619.4 0.4 3.6e-186 619.2 0.4 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF4149 PF13664.6 EXF80613.1 - 0.15 12.4 3.0 13 6.1 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4149) DUF3593 PF12159.8 EXF80613.1 - 9.2 6.4 7.3 1.5 8.9 1.4 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF3593) HAMP PF00672.25 EXF80614.1 - 1.9e-38 130.6 21.1 4.6e-08 33.3 0.4 8.0 7 1 1 8 8 8 6 HAMP domain HATPase_c PF02518.26 EXF80614.1 - 1.2e-30 106.3 0.1 5.3e-30 104.2 0.1 2.2 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EXF80614.1 - 1.5e-26 92.8 1.0 9.6e-26 90.2 0.3 2.7 2 0 0 2 2 2 1 Response regulator receiver domain HisKA PF00512.25 EXF80614.1 - 2.2e-17 62.8 3.8 7.8e-17 61.1 0.5 3.7 3 0 0 3 3 3 1 His Kinase A (phospho-acceptor) domain Syntaxin_2 PF14523.6 EXF80614.1 - 2.4e-07 31.1 15.2 3.4 8.1 0.2 7.5 2 1 2 6 6 6 3 Syntaxin-like protein DUF4279 PF14106.6 EXF80614.1 - 0.00079 19.6 0.0 36 4.6 0.0 5.6 6 0 0 6 6 5 0 Domain of unknown function (DUF4279) Fib_alpha PF08702.10 EXF80614.1 - 0.0017 18.6 35.3 0.082 13.1 0.8 7.4 7 1 1 8 8 8 2 Fibrinogen alpha/beta chain family DUF948 PF06103.11 EXF80614.1 - 0.0021 18.3 45.9 0.33 11.2 1.2 9.3 4 3 2 6 6 6 3 Bacterial protein of unknown function (DUF948) DUF3829 PF12889.7 EXF80614.1 - 0.013 15.0 9.9 1.2 8.5 0.1 4.6 4 2 0 4 4 4 0 Protein of unknown function (DUF3829) DUF1759 PF03564.15 EXF80614.1 - 0.017 15.0 0.3 39 4.1 0.1 4.3 4 0 0 4 4 4 0 Protein of unknown function (DUF1759) HTH_6 PF01418.17 EXF80614.1 - 0.11 12.5 0.0 18 5.4 0.0 3.7 3 0 0 3 3 3 0 Helix-turn-helix domain, rpiR family DUF4795 PF16043.5 EXF80614.1 - 0.13 11.9 26.0 9 5.8 1.6 5.7 1 1 1 3 3 3 0 Domain of unknown function (DUF4795) UBD PF16455.5 EXF80614.1 - 0.29 11.4 1.2 2.9 8.2 0.1 2.9 2 0 0 2 2 2 0 Ubiquitin-binding domain Laminin_II PF06009.12 EXF80614.1 - 0.5 10.4 38.4 0.44 10.6 0.2 7.9 7 1 1 8 8 8 0 Laminin Domain II R3H PF01424.22 EXF80615.1 - 6.9e-16 58.0 0.2 1.3e-15 57.1 0.2 1.5 1 0 0 1 1 1 1 R3H domain zf-NF-X1 PF01422.17 EXF80615.1 - 9.5e-05 22.4 52.5 0.00069 19.6 14.7 13.2 13 1 0 13 13 13 6 NF-X1 type zinc finger Methyltransf_23 PF13489.6 EXF80616.1 - 4.7e-24 85.1 0.0 6.4e-24 84.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF80616.1 - 2.9e-11 43.9 0.0 5.7e-11 43.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF80616.1 - 1.7e-10 40.9 0.0 4e-10 39.7 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF80616.1 - 1.3e-08 35.5 0.0 4.5e-08 33.7 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF80616.1 - 9.5e-08 32.6 0.0 1.8e-07 31.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EXF80616.1 - 0.0025 17.2 0.0 0.0042 16.4 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Met_10 PF02475.16 EXF80616.1 - 0.0037 17.1 0.0 0.006 16.4 0.0 1.3 1 0 0 1 1 1 1 Met-10+ like-protein PrmA PF06325.13 EXF80616.1 - 0.0049 16.3 0.0 0.0069 15.8 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 EXF80616.1 - 0.011 15.3 0.0 0.022 14.3 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase small domain FtsJ PF01728.19 EXF80616.1 - 0.045 13.9 0.0 0.097 12.8 0.0 1.4 1 1 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_16 PF10294.9 EXF80616.1 - 0.046 13.5 0.0 0.081 12.7 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase Methyltransf_23 PF13489.6 EXF80617.1 - 5.7e-19 68.5 0.0 8.3e-19 68.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF80617.1 - 3.8e-10 40.4 0.0 8.1e-10 39.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF80617.1 - 1.7e-09 38.3 0.0 6.3e-09 36.5 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF80617.1 - 1.3e-08 34.7 0.0 8e-08 32.2 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF80617.1 - 2.2e-07 31.4 0.0 4e-07 30.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.19 EXF80617.1 - 0.0016 18.5 0.0 0.0023 18.1 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_4 PF02390.17 EXF80617.1 - 0.028 13.9 0.0 0.057 12.9 0.0 1.4 1 0 0 1 1 1 0 Putative methyltransferase Methyltransf_2 PF00891.18 EXF80617.1 - 0.04 13.2 0.0 0.13 11.6 0.0 1.8 1 1 0 1 1 1 0 O-methyltransferase domain CheR PF01739.18 EXF80617.1 - 0.049 13.1 0.0 0.091 12.2 0.0 1.3 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain CopK PF11525.8 EXF80617.1 - 0.065 12.9 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 Copper resistance protein K MTS PF05175.14 EXF80617.1 - 0.069 12.7 0.0 0.22 11.0 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase small domain RTA1 PF04479.13 EXF80618.1 - 2.4e-37 128.6 2.4 2.4e-37 128.6 2.4 1.6 2 0 0 2 2 2 1 RTA1 like protein Abhydrolase_6 PF12697.7 EXF80619.1 - 9.9e-16 59.0 0.1 1.3e-15 58.6 0.1 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EXF80619.1 - 0.0016 17.7 0.1 0.0027 17.0 0.1 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EXF80619.1 - 0.0052 16.5 0.1 4.7 6.8 0.0 2.8 3 0 0 3 3 3 2 alpha/beta hydrolase fold Ser_hydrolase PF06821.13 EXF80619.1 - 0.013 15.3 0.0 0.19 11.6 0.0 2.1 2 0 0 2 2 2 0 Serine hydrolase Thioesterase PF00975.20 EXF80619.1 - 0.046 13.8 0.1 0.14 12.3 0.0 1.7 2 0 0 2 2 2 0 Thioesterase domain DUF900 PF05990.12 EXF80619.1 - 0.051 13.1 0.0 0.077 12.5 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) TBCA PF02970.16 EXF80620.1 - 1.6e-21 76.4 3.8 2.3e-21 75.9 3.8 1.3 1 0 0 1 1 1 1 Tubulin binding cofactor A Cytochrom_C552 PF02335.15 EXF80620.1 - 0.048 12.6 0.2 0.064 12.2 0.2 1.1 1 0 0 1 1 1 0 Cytochrome c552 Csm1_N PF18504.1 EXF80620.1 - 2.8 8.3 7.7 1.1 9.7 1.1 2.7 1 1 2 3 3 3 0 Csm1 N-terminal domain THOC7 PF05615.13 EXF80621.1 - 2.9e-42 144.1 4.7 2.9e-42 144.1 4.7 2.1 1 1 1 2 2 2 1 Tho complex subunit 7 FUSC PF04632.12 EXF80621.1 - 0.2 10.2 3.6 0.25 9.8 3.6 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family YabA PF06156.13 EXF80621.1 - 0.2 12.3 8.0 1.8 9.3 0.3 2.5 2 0 0 2 2 2 0 Initiation control protein YabA Herpes_UL17 PF04559.12 EXF80621.1 - 0.68 8.7 5.9 0.13 11.1 2.5 1.5 2 0 0 2 2 2 0 Herpesvirus UL17 protein DHR10 PF18595.1 EXF80621.1 - 1.1 9.3 17.9 3.5 7.7 3.9 2.6 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain DUF4407 PF14362.6 EXF80621.1 - 2.6 7.3 10.2 3.8 6.8 10.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Sec66 PF09802.9 EXF80621.1 - 7.7 6.1 9.7 1.1 8.8 1.8 2.1 2 0 0 2 2 2 0 Preprotein translocase subunit Sec66 zf_CCCH_4 PF18345.1 EXF80622.1 - 8.7e-07 28.8 29.1 0.0054 16.7 0.5 6.0 5 1 0 5 5 5 4 Zinc finger domain zf-CCCH PF00642.24 EXF80622.1 - 1.3e-05 24.9 25.3 0.22 11.5 0.3 5.5 4 1 1 5 5 5 4 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 EXF80622.1 - 5.1e-05 23.0 1.2 0.01 15.6 0.2 4.7 6 0 0 6 6 6 2 CCCH-type zinc finger zf-CCCH_3 PF15663.5 EXF80622.1 - 0.0014 18.8 17.5 0.048 13.9 1.0 3.9 1 1 2 3 3 3 3 Zinc-finger containing family Torus PF16131.5 EXF80622.1 - 0.51 11.1 26.3 3.1 8.5 0.1 5.2 2 1 3 5 5 5 0 Torus domain Sel1 PF08238.12 EXF80623.1 - 1.8e-13 50.7 4.4 0.0013 19.3 0.4 3.9 4 0 0 4 4 4 3 Sel1 repeat TraC PF07820.12 EXF80623.1 - 0.27 11.6 3.5 0.36 11.2 0.1 2.6 2 0 0 2 2 2 0 TraC-like protein Atx10homo_assoc PF09759.9 EXF80624.1 - 4.3e-12 45.9 0.0 9.5e-12 44.8 0.0 1.6 1 0 0 1 1 1 1 Spinocerebellar ataxia type 10 protein domain tRNA-synt_1b PF00579.25 EXF80625.1 - 1.7e-59 201.6 0.0 2.1e-59 201.3 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) PNP_UDP_1 PF01048.20 EXF80626.1 - 1.5e-40 138.9 0.3 2e-40 138.5 0.3 1.1 1 0 0 1 1 1 1 Phosphorylase superfamily Med13_C PF06333.12 EXF80627.1 - 2.1e-91 306.6 0.3 2.1e-91 306.6 0.3 2.7 3 0 0 3 3 3 1 Mediator complex subunit 13 C-terminal domain Med13_N PF11597.8 EXF80627.1 - 1.3e-28 100.3 1.6 2.6e-28 99.3 1.6 1.5 1 0 0 1 1 1 1 Mediator complex subunit 13 N-terminal MID_MedPIWI PF18296.1 EXF80627.1 - 8.9e-14 51.9 0.6 4.6e-06 26.6 0.0 3.0 3 0 0 3 3 3 2 MID domain of medPIWI DUF499 PF04465.12 EXF80627.1 - 0.17 9.6 0.0 0.31 8.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF499) NUC153 PF08159.12 EXF80628.1 - 1.3e-11 44.1 3.2 2.9e-11 43.0 3.2 1.7 1 0 0 1 1 1 1 NUC153 domain WD40 PF00400.32 EXF80628.1 - 4.7e-05 24.1 0.1 7.4 7.6 0.0 4.1 4 0 0 4 4 4 2 WD domain, G-beta repeat TMEM210 PF15195.6 EXF80629.1 - 0.033 14.6 0.3 0.047 14.1 0.3 1.2 1 0 0 1 1 1 0 TMEM210 family DUF2371 PF10177.9 EXF80629.1 - 0.051 13.7 0.0 0.068 13.3 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2371) DUF3918 PF13056.6 EXF80629.1 - 0.052 13.2 0.2 0.085 12.5 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3918) Ribosomal_L33 PF00471.20 EXF80631.1 - 7.7e-06 26.3 0.0 1.1e-05 25.8 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L33 Aminotran_1_2 PF00155.21 EXF80632.1 - 2.2e-38 132.4 0.0 3.1e-38 131.9 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EXF80632.1 - 0.069 11.7 0.0 0.12 10.9 0.0 1.3 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme RPN7 PF10602.9 EXF80633.1 - 1.4e-56 191.0 2.2 1.4e-56 190.9 0.5 1.8 2 0 0 2 2 2 1 26S proteasome subunit RPN7 PCI PF01399.27 EXF80633.1 - 1.3e-15 57.8 0.0 3e-15 56.6 0.0 1.6 1 0 0 1 1 1 1 PCI domain TPR_14 PF13428.6 EXF80633.1 - 0.089 13.7 1.5 2.5 9.1 0.1 3.2 2 0 0 2 2 2 0 Tetratricopeptide repeat Pox_MCEL PF03291.16 EXF80634.1 - 5.1e-71 239.5 0.0 3.7e-48 164.3 0.0 2.3 2 0 0 2 2 2 2 mRNA capping enzyme Methyltransf_25 PF13649.6 EXF80634.1 - 9.5e-11 42.3 0.1 9.8e-05 23.0 0.0 2.7 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 EXF80634.1 - 5.8e-09 36.6 0.1 0.0042 17.8 0.0 3.1 3 0 0 3 3 3 2 Methyltransferase domain Methyltransf_11 PF08241.12 EXF80634.1 - 3.3e-07 30.9 0.1 0.035 14.7 0.0 2.5 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_31 PF13847.6 EXF80634.1 - 3.8e-06 26.8 0.0 0.00085 19.1 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_23 PF13489.6 EXF80634.1 - 1.2e-05 25.2 0.0 2.5e-05 24.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain NNMT_PNMT_TEMT PF01234.17 EXF80634.1 - 0.00031 20.0 0.0 0.00049 19.4 0.0 1.2 1 0 0 1 1 1 1 NNMT/PNMT/TEMT family Methyltransf_9 PF08003.11 EXF80634.1 - 0.17 10.8 0.0 0.38 9.6 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1698) Ysc84 PF04366.12 EXF80639.1 - 3.6e-42 143.1 0.5 7.5e-42 142.1 0.5 1.5 1 0 0 1 1 1 1 Las17-binding protein actin regulator SH3_1 PF00018.28 EXF80639.1 - 1.5e-13 50.1 0.2 4.1e-13 48.7 0.0 1.8 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.17 EXF80639.1 - 3.8e-12 45.7 0.0 9.1e-12 44.5 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 EXF80639.1 - 5.8e-11 42.1 0.0 1.2e-10 41.1 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain DUF3104 PF11302.8 EXF80639.1 - 0.02 14.6 0.1 0.045 13.5 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3104) Synaptobrevin PF00957.21 EXF80641.1 - 0.0019 17.9 0.9 0.016 15.0 0.4 2.0 1 1 1 2 2 2 2 Synaptobrevin ArfGap PF01412.18 EXF80642.1 - 5.2e-39 132.9 1.3 7.7e-39 132.4 1.3 1.2 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf partial_CstF PF15861.5 EXF80642.1 - 0.088 12.6 0.0 0.17 11.7 0.0 1.3 1 0 0 1 1 1 0 Partial cleavage stimulation factor domain 2-Hacid_dh_C PF02826.19 EXF80643.1 - 2.1e-52 177.1 0.1 3.5e-52 176.4 0.1 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EXF80643.1 - 3.2e-35 120.7 1.4 4.8e-35 120.1 0.6 1.6 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain ACT PF01842.25 EXF80643.1 - 5.4e-05 22.9 0.2 0.00031 20.4 0.0 2.4 2 0 0 2 2 2 1 ACT domain XdhC_C PF13478.6 EXF80643.1 - 0.016 15.7 0.0 0.036 14.6 0.0 1.7 1 0 0 1 1 1 0 XdhC Rossmann domain DUF21 PF01595.20 EXF80644.1 - 2.1e-33 115.5 0.0 3.6e-33 114.7 0.0 1.3 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain CBS PF00571.28 EXF80644.1 - 0.00051 20.4 0.2 0.036 14.5 0.0 3.1 2 1 0 2 2 2 1 CBS domain Lactonase PF10282.9 EXF80645.1 - 1.9e-18 66.9 0.0 2.3e-18 66.6 0.0 1.1 1 0 0 1 1 1 1 Lactonase, 7-bladed beta-propeller Ank_2 PF12796.7 EXF80646.1 - 2.4e-24 85.7 0.6 2.3e-10 40.9 0.0 4.1 2 1 3 5 5 5 4 Ankyrin repeats (3 copies) AAA_16 PF13191.6 EXF80646.1 - 6.3e-12 46.2 1.5 9e-12 45.7 0.2 2.0 2 0 0 2 2 1 1 AAA ATPase domain Ank PF00023.30 EXF80646.1 - 1.2e-11 44.5 0.5 0.00084 19.7 0.0 4.8 4 0 0 4 4 4 3 Ankyrin repeat Ank_3 PF13606.6 EXF80646.1 - 4e-10 39.0 3.1 0.0013 19.0 0.0 5.4 5 1 1 6 6 5 2 Ankyrin repeat Ank_4 PF13637.6 EXF80646.1 - 1.2e-08 35.3 0.7 1.3e-05 25.7 0.1 4.1 3 1 1 4 4 3 2 Ankyrin repeats (many copies) AAA_22 PF13401.6 EXF80646.1 - 1.9e-07 31.4 0.1 6e-07 29.8 0.1 1.8 1 0 0 1 1 1 1 AAA domain Ank_5 PF13857.6 EXF80646.1 - 2.6e-05 24.4 1.7 0.0012 19.1 0.1 3.7 2 2 2 4 4 4 2 Ankyrin repeats (many copies) NACHT PF05729.12 EXF80646.1 - 4.6e-05 23.4 0.3 0.00012 22.0 0.1 1.8 2 0 0 2 2 2 1 NACHT domain AAA_5 PF07728.14 EXF80646.1 - 0.00024 21.1 0.0 0.00094 19.2 0.0 2.0 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA PF00004.29 EXF80646.1 - 0.0003 21.2 0.0 0.00086 19.7 0.0 1.9 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 EXF80646.1 - 0.0036 17.5 0.0 0.07 13.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 EXF80646.1 - 0.011 15.4 0.0 0.11 12.3 0.0 2.4 3 0 0 3 3 3 0 P-loop containing region of AAA domain AAA_18 PF13238.6 EXF80646.1 - 0.019 15.5 0.0 0.65 10.6 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 EXF80646.1 - 0.027 14.0 0.0 0.057 12.9 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region IstB_IS21 PF01695.17 EXF80646.1 - 0.079 12.7 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein NB-ARC PF00931.22 EXF80646.1 - 0.096 11.9 0.0 0.33 10.1 0.0 1.8 2 0 0 2 2 2 0 NB-ARC domain KAP_NTPase PF07693.14 EXF80646.1 - 0.11 11.8 0.1 13 4.9 0.0 2.2 1 1 1 2 2 2 0 KAP family P-loop domain ABC_tran PF00005.27 EXF80647.1 - 2.8e-34 118.6 0.0 1.5e-16 61.2 0.0 2.5 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EXF80647.1 - 1.9e-33 116.3 16.0 1.5e-23 83.8 3.5 2.4 2 0 0 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.19 EXF80647.1 - 2.5e-07 30.4 0.3 0.023 14.1 0.0 3.2 3 0 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EXF80647.1 - 0.0016 18.3 2.3 0.17 11.6 0.1 3.3 4 0 0 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EXF80647.1 - 0.0052 16.5 0.2 0.019 14.7 0.0 2.0 2 0 0 2 2 1 1 P-loop containing region of AAA domain AAA_22 PF13401.6 EXF80647.1 - 0.011 16.0 2.6 0.063 13.5 0.6 3.0 2 1 0 2 2 2 0 AAA domain AAA_16 PF13191.6 EXF80647.1 - 0.013 15.9 0.2 0.069 13.5 0.0 2.3 2 1 0 2 2 2 0 AAA ATPase domain RsgA_GTPase PF03193.16 EXF80647.1 - 0.015 15.2 0.0 0.09 12.7 0.0 2.0 2 0 0 2 2 2 0 RsgA GTPase AAA PF00004.29 EXF80647.1 - 0.016 15.6 0.8 0.41 11.1 0.1 2.6 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 EXF80647.1 - 0.02 14.8 0.1 0.068 13.1 0.0 1.8 2 0 0 2 2 2 0 Rad17 P-loop domain NB-ARC PF00931.22 EXF80647.1 - 0.056 12.6 0.0 0.21 10.7 0.0 1.9 2 1 0 2 2 2 0 NB-ARC domain MMR_HSR1 PF01926.23 EXF80647.1 - 0.095 12.8 0.0 0.66 10.1 0.0 2.3 2 0 0 2 2 2 0 50S ribosome-binding GTPase T2SSE PF00437.20 EXF80647.1 - 0.15 11.1 0.0 0.27 10.2 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_23 PF13476.6 EXF80647.1 - 0.16 12.5 0.2 0.38 11.2 0.2 1.5 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 EXF80647.1 - 0.16 11.8 0.0 0.48 10.3 0.0 1.7 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea Exo_endo_phos PF03372.23 EXF80649.1 - 3.3e-05 23.5 0.7 7.2e-05 22.4 0.7 1.5 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family HET PF06985.11 EXF80650.1 - 7.3e-25 88.0 0.3 9.4e-24 84.4 0.3 2.5 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) SelR PF01641.18 EXF80651.1 - 4e-48 162.5 0.0 5.4e-48 162.1 0.0 1.2 1 0 0 1 1 1 1 SelR domain DZR PF12773.7 EXF80651.1 - 0.063 13.3 0.2 6.2 6.9 0.1 2.3 2 0 0 2 2 2 0 Double zinc ribbon Yippee-Mis18 PF03226.14 EXF80651.1 - 0.12 12.6 0.2 0.28 11.4 0.2 1.6 1 1 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Glyoxalase PF00903.25 EXF80652.1 - 5.4e-38 130.1 0.2 4.9e-18 65.5 0.0 2.3 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 EXF80652.1 - 5.4e-17 62.0 0.1 1.5e-07 31.7 0.0 3.4 2 2 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.6 EXF80652.1 - 8.7e-07 29.2 0.0 0.048 13.8 0.0 3.6 2 2 0 2 2 2 2 Glyoxalase-like domain Glyoxalase_2 PF12681.7 EXF80652.1 - 5.8e-06 26.2 2.5 0.058 13.3 0.3 4.4 3 2 0 3 3 3 1 Glyoxalase-like domain Glyoxalase_6 PF18029.1 EXF80652.1 - 1.4e-05 25.8 0.0 0.091 13.6 0.0 2.9 2 1 0 2 2 2 2 Glyoxalase-like domain CppA_N PF14506.6 EXF80652.1 - 0.00027 21.0 0.0 0.17 12.0 0.0 2.4 2 0 0 2 2 2 2 CppA N-terminal DUF1338 PF07063.13 EXF80652.1 - 0.00058 19.1 0.0 0.49 9.5 0.0 3.2 3 1 0 3 3 3 1 Domain of unknown function (DUF1338) Pfk_N PF18468.1 EXF80652.1 - 0.0012 19.2 0.3 0.57 10.6 0.0 2.4 2 0 0 2 2 2 2 Phosphofructokinase N-terminal domain yeast MoaF PF10703.9 EXF80652.1 - 0.01 15.8 0.1 2.4 8.1 0.0 2.4 2 0 0 2 2 2 0 MoaF N-terminal domain GCD14_N PF14801.6 EXF80652.1 - 0.13 12.1 0.0 2.8 7.9 0.0 2.5 2 0 0 2 2 2 0 tRNA methyltransferase complex GCD14 subunit N-term Piwi PF02171.17 EXF80653.1 - 7.4e-71 238.8 0.0 1.1e-70 238.3 0.0 1.2 1 0 0 1 1 1 1 Piwi domain ArgoL1 PF08699.10 EXF80653.1 - 3.2e-11 42.7 0.2 8.2e-11 41.4 0.2 1.7 1 0 0 1 1 1 1 Argonaute linker 1 domain ArgoN PF16486.5 EXF80653.1 - 1.3e-07 32.3 0.0 2.8e-07 31.2 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of argonaute ArgoL2 PF16488.5 EXF80653.1 - 1.9e-07 31.3 0.0 1.9e-06 28.1 0.0 2.3 2 0 0 2 2 2 1 Argonaute linker 2 domain ArgoMid PF16487.5 EXF80653.1 - 4.9e-06 26.7 0.0 1.3e-05 25.4 0.0 1.7 1 0 0 1 1 1 1 Mid domain of argonaute PAZ PF02170.22 EXF80653.1 - 0.005 16.7 0.0 0.01 15.6 0.0 1.5 1 0 0 1 1 1 1 PAZ domain Inv-AAD PF18785.1 EXF80654.1 - 2e-60 202.3 0.1 2.3e-60 202.1 0.1 1.0 1 0 0 1 1 1 1 Invertebrate-AID/APOBEC-deaminase dCMP_cyt_deam_1 PF00383.23 EXF80654.1 - 4e-14 52.3 0.0 5.7e-14 51.8 0.0 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region APOBEC_N PF08210.11 EXF80654.1 - 0.0001 22.2 0.0 0.00012 22.0 0.0 1.2 1 0 0 1 1 1 1 APOBEC-like N-terminal domain SNAD4 PF18750.1 EXF80654.1 - 0.15 12.2 0.0 0.19 11.9 0.0 1.2 1 0 0 1 1 1 0 Secreted Novel AID/APOBEC-like Deaminase 4 DnaJ PF00226.31 EXF80655.1 - 8e-23 80.4 2.0 2.4e-22 78.8 2.0 1.9 1 0 0 1 1 1 1 DnaJ domain Nif11 PF07862.11 EXF80655.1 - 0.0011 19.2 2.4 0.76 10.1 0.0 3.8 3 1 0 3 3 3 1 Nif11 domain DUF325 PF03804.13 EXF80655.1 - 0.084 12.9 0.0 0.17 11.9 0.0 1.4 1 0 0 1 1 1 0 Viral proteins of unknown function Glyco_hydro81C PF17652.1 EXF80656.1 - 4.5e-157 522.7 5.0 6.1e-157 522.3 5.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 81 C-terminal domain Glyco_hydro_81 PF03639.13 EXF80656.1 - 8.7e-120 399.7 1.4 1.5e-119 398.9 1.4 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 81 N-terminal domain Stn1 PF10451.9 EXF80656.1 - 3.3e-12 45.9 2.4 6.2e-06 25.4 0.0 2.2 2 0 0 2 2 2 2 Telomere regulation protein Stn1 TAF4 PF05236.14 EXF80656.1 - 1.7 8.4 12.1 2.9 7.6 12.1 1.3 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family MCM_bind PF09739.9 EXF80656.1 - 3.5 6.0 4.5 5.2 5.4 4.5 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Na_Ca_ex PF01699.24 EXF80658.1 - 5.5e-46 156.3 34.5 5.8e-25 88.0 14.5 2.2 2 0 0 2 2 2 2 Sodium/calcium exchanger protein Utp14 PF04615.13 EXF80659.1 - 1.7e-192 642.0 79.8 1.7e-192 642.0 79.8 2.1 1 1 1 2 2 2 1 Utp14 protein COX15-CtaA PF02628.15 EXF80660.1 - 2.5e-110 368.6 6.8 3.1e-110 368.3 6.8 1.1 1 0 0 1 1 1 1 Cytochrome oxidase assembly protein CAF-1_p60_C PF15512.6 EXF80660.1 - 0.78 10.2 5.1 1.2 9.6 5.1 1.2 1 0 0 1 1 1 0 Chromatin assembly factor complex 1 subunit p60, C-terminal tRNA-synt_2 PF00152.20 EXF80661.1 - 2.2e-74 250.4 0.5 3e-74 250.0 0.5 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA-synt_2d PF01409.20 EXF80661.1 - 2e-05 24.2 0.4 0.067 12.7 0.1 2.3 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) tRNA_anti-codon PF01336.25 EXF80661.1 - 0.0079 16.2 0.0 0.025 14.5 0.0 2.0 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain Hc1 PF07432.13 EXF80661.1 - 0.56 10.6 11.5 1 9.7 10.6 1.8 2 0 0 2 2 2 0 Histone H1-like protein Hc1 DUF4936 PF16290.5 EXF80662.1 - 9.7e-05 23.0 0.1 0.00014 22.5 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4936) Peptidase_S58 PF03576.14 EXF80663.1 - 2.8e-114 381.7 0.7 3.2e-114 381.5 0.7 1.0 1 0 0 1 1 1 1 Peptidase family S58 Fe-ADH PF00465.19 EXF80664.1 - 8.6e-100 334.1 0.0 1.1e-99 333.7 0.0 1.0 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 EXF80664.1 - 1.5e-12 47.8 0.0 9e-10 38.7 0.0 2.3 2 0 0 2 2 2 2 Iron-containing alcohol dehydrogenase Peripla_BP_6 PF13458.6 EXF80664.1 - 0.0076 16.0 0.1 0.014 15.1 0.1 1.3 1 0 0 1 1 1 1 Periplasmic binding protein Deltaretro_Tax PF05599.11 EXF80664.1 - 0.19 12.2 4.6 0.69 10.5 3.0 2.4 2 0 0 2 2 2 0 Deltaretrovirus Tax protein 2OG-FeII_Oxy_2 PF13532.6 EXF80665.1 - 9.4e-29 101.0 0.0 1.4e-28 100.5 0.0 1.2 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Pkinase PF00069.25 EXF80666.1 - 2.1e-69 233.8 0.0 2.8e-69 233.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF80666.1 - 5.5e-30 104.5 0.0 7.2e-30 104.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EXF80666.1 - 0.0019 17.6 0.0 0.003 16.9 0.0 1.4 1 1 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EXF80666.1 - 0.0021 17.0 0.0 0.015 14.3 0.0 1.9 2 0 0 2 2 2 1 Haspin like kinase domain APH PF01636.23 EXF80666.1 - 0.0034 17.3 0.0 0.0053 16.7 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 EXF80666.1 - 0.029 13.4 0.0 0.043 12.9 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 ADH_zinc_N PF00107.26 EXF80670.1 - 1.1e-14 54.5 0.1 2e-14 53.7 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EXF80670.1 - 0.033 14.1 0.0 0.084 12.8 0.0 1.7 1 0 0 1 1 1 0 Alcohol dehydrogenase GroES-like domain WD40 PF00400.32 EXF80672.1 - 7.2e-09 36.1 17.8 0.0025 18.6 0.4 5.3 4 0 0 4 4 4 2 WD domain, G-beta repeat Zn_ribbon_17 PF17120.5 EXF80672.1 - 2.7e-06 26.9 9.3 5.9e-06 25.8 9.3 1.6 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type RWD PF05773.22 EXF80672.1 - 0.0022 18.3 0.0 0.0053 17.0 0.0 1.6 1 0 0 1 1 1 1 RWD domain SBP_bac_11 PF13531.6 EXF80672.1 - 0.11 12.3 0.8 0.21 11.3 0.1 1.8 2 0 0 2 2 2 0 Bacterial extracellular solute-binding protein zf-RING_2 PF13639.6 EXF80672.1 - 0.65 10.4 10.9 0.027 14.8 4.6 2.0 2 0 0 2 2 2 0 Ring finger domain zf-RING_UBOX PF13445.6 EXF80672.1 - 0.84 9.7 6.7 1.8 8.6 6.7 1.6 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_9 PF13901.6 EXF80672.1 - 1.1 9.2 7.5 2.7 7.9 7.5 1.6 1 1 0 1 1 1 0 Putative zinc-RING and/or ribbon zf-rbx1 PF12678.7 EXF80672.1 - 4.4 7.7 13.7 0.081 13.2 6.2 2.0 2 0 0 2 2 2 0 RING-H2 zinc finger domain UQ_con PF00179.26 EXF80673.1 - 6.1e-48 162.0 0.0 6.9e-48 161.9 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EXF80673.1 - 0.00055 19.7 0.0 0.00074 19.2 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 EXF80673.1 - 0.0042 16.9 0.1 0.0082 16.0 0.1 1.5 1 1 0 1 1 1 1 UEV domain RWD PF05773.22 EXF80673.1 - 0.07 13.4 0.0 0.091 13.1 0.0 1.3 1 0 0 1 1 1 0 RWD domain HET PF06985.11 EXF80674.1 - 6.3e-23 81.7 0.0 3.8e-19 69.5 0.1 2.5 2 0 0 2 2 2 2 Heterokaryon incompatibility protein (HET) GPI2 PF06432.11 EXF80676.1 - 1.1e-135 451.5 0.7 1.3e-135 451.3 0.7 1.1 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase MDMPI_N PF11716.8 EXF80677.1 - 0.015 15.9 0.0 0.022 15.4 0.0 1.2 1 0 0 1 1 1 0 Mycothiol maleylpyruvate isomerase N-terminal domain Ank_2 PF12796.7 EXF80679.1 - 8.3e-16 58.3 0.1 2e-07 31.5 0.1 3.9 1 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EXF80679.1 - 1.6e-14 54.0 1.9 0.0033 18.0 0.0 5.8 4 1 1 5 5 5 3 Ankyrin repeats (many copies) Ank PF00023.30 EXF80679.1 - 2.4e-09 37.2 1.5 0.0019 18.5 0.0 4.7 5 0 0 5 5 5 2 Ankyrin repeat Ank_3 PF13606.6 EXF80679.1 - 9.9e-07 28.6 2.5 5.2 8.0 0.0 6.4 6 0 0 6 6 6 1 Ankyrin repeat Ank_5 PF13857.6 EXF80679.1 - 1.7e-05 25.0 0.8 0.82 10.1 0.1 5.1 4 1 1 5 5 5 2 Ankyrin repeats (many copies) AAA_16 PF13191.6 EXF80679.1 - 6.6e-05 23.4 0.2 0.00092 19.6 0.0 2.6 2 0 0 2 2 2 1 AAA ATPase domain NACHT PF05729.12 EXF80679.1 - 8.3e-05 22.6 1.6 0.00022 21.2 0.2 2.4 2 1 0 2 2 2 1 NACHT domain AAA_22 PF13401.6 EXF80679.1 - 0.0023 18.2 0.1 0.011 15.9 0.0 2.2 3 0 0 3 3 3 1 AAA domain KAP_NTPase PF07693.14 EXF80679.1 - 0.044 13.0 0.5 1 8.6 0.2 2.3 1 1 0 2 2 2 0 KAP family P-loop domain PRCC PF10253.9 EXF80679.1 - 0.35 11.6 5.6 0.67 10.7 5.6 1.4 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting Lyase_1 PF00206.20 EXF80680.1 - 3.1e-113 378.3 0.0 4.2e-113 377.9 0.0 1.2 1 0 0 1 1 1 1 Lyase FumaraseC_C PF10415.9 EXF80680.1 - 1.2e-21 76.8 0.0 3.1e-21 75.5 0.0 1.8 1 0 0 1 1 1 1 Fumarase C C-terminus T7SS_ESX_EspC PF10824.8 EXF80680.1 - 0.12 12.9 0.3 0.43 11.1 0.3 2.0 1 0 0 1 1 1 0 Excreted virulence factor EspC, type VII ESX diderm Annexin PF00191.20 EXF80682.1 - 6.9e-16 58.1 0.2 0.00052 20.0 0.0 4.3 4 0 0 4 4 4 3 Annexin DUF5617 PF18493.1 EXF80682.1 - 0.028 14.5 0.2 0.066 13.3 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5617) Spt5_N PF11942.8 EXF80682.1 - 6.7 7.8 8.4 1.1 10.3 0.2 3.5 3 0 0 3 3 3 0 Spt5 transcription elongation factor, acidic N-terminal Myosin_head PF00063.21 EXF80683.1 - 1.3e-268 892.9 0.0 1.3e-268 892.9 0.0 1.8 2 0 0 2 2 2 1 Myosin head (motor domain) Myosin_N PF02736.19 EXF80683.1 - 4.9e-13 48.7 0.5 1.2e-12 47.5 0.5 1.7 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain Myosin_tail_1 PF01576.19 EXF80683.1 - 1.1e-10 40.1 52.4 1.1e-10 40.1 52.4 5.3 2 2 2 4 4 4 3 Myosin tail AAA_22 PF13401.6 EXF80683.1 - 0.09 13.1 0.0 0.09 13.1 0.0 4.7 5 0 0 5 5 5 0 AAA domain Spo7 PF03907.13 EXF80683.1 - 0.13 11.8 5.9 0.17 11.4 0.1 3.2 2 0 0 2 2 2 0 Spo7-like protein UDPG_MGDP_dh_N PF03721.14 EXF80683.1 - 0.31 10.6 3.8 0.98 9.0 3.8 1.8 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain zf-CCCH PF00642.24 EXF80684.1 - 0.073 13.0 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Spc24 PF08286.11 EXF80684.1 - 0.68 10.2 5.1 2.8 8.2 5.1 2.1 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 FemAB PF02388.16 EXF80684.1 - 1.2 7.9 4.4 2.7 6.8 4.4 1.5 1 0 0 1 1 1 0 FemAB family RTA1 PF04479.13 EXF80685.1 - 1.6e-76 256.6 2.7 1.6e-76 256.6 2.7 2.0 1 1 1 2 2 2 2 RTA1 like protein Peptidase_S9 PF00326.21 EXF80685.1 - 0.23 10.9 0.1 0.39 10.2 0.1 1.2 1 0 0 1 1 1 0 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 EXF80686.1 - 2.1e-23 83.3 0.2 1.2e-22 80.8 0.2 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydro_lipase PF04083.16 EXF80686.1 - 3.2e-21 74.7 0.1 6.2e-21 73.8 0.1 1.5 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Hydrolase_4 PF12146.8 EXF80686.1 - 0.00015 21.1 0.0 0.016 14.5 0.0 2.4 1 1 0 1 1 1 1 Serine aminopeptidase, S33 FSH1 PF03959.13 EXF80686.1 - 0.00034 20.3 0.1 0.33 10.6 0.0 2.3 2 0 0 2 2 2 2 Serine hydrolase (FSH1) Abhydrolase_2 PF02230.16 EXF80686.1 - 0.16 11.7 0.1 25 4.6 0.0 2.4 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Pet191_N PF10203.9 EXF80687.1 - 1.6e-27 95.6 4.9 2e-27 95.2 4.9 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein PET191 COBRA PF04833.15 EXF80687.1 - 0.061 13.2 0.3 0.084 12.8 0.3 1.3 1 0 0 1 1 1 0 COBRA-like protein PAN_3 PF08277.12 EXF80687.1 - 0.089 12.6 0.6 0.17 11.7 0.6 1.5 1 0 0 1 1 1 0 PAN-like domain CX9C PF16860.5 EXF80687.1 - 0.18 11.8 8.5 0.44 10.6 1.1 2.7 1 1 2 3 3 3 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, ACPS PF01648.20 EXF80688.1 - 2.3e-07 30.9 0.0 9.8e-07 28.9 0.0 2.0 2 1 0 2 2 2 1 4'-phosphopantetheinyl transferase superfamily HCO3_cotransp PF00955.21 EXF80690.1 - 2e-71 241.4 6.8 1.4e-39 136.3 0.0 2.1 1 1 1 2 2 2 2 HCO3- transporter family adh_short PF00106.25 EXF80690.1 - 1.2e-24 86.9 0.0 2e-24 86.1 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF80690.1 - 3.4e-21 75.9 0.0 1.9e-20 73.4 0.0 2.1 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase MMR_HSR1 PF01926.23 EXF80691.1 - 3.3e-11 43.3 0.0 5.8e-11 42.5 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EXF80691.1 - 0.00019 21.4 0.3 0.00036 20.5 0.3 1.4 1 0 0 1 1 1 1 RsgA GTPase FeoB_N PF02421.18 EXF80691.1 - 0.0014 18.1 0.0 0.0043 16.6 0.0 1.8 2 0 0 2 2 2 1 Ferrous iron transport protein B MeaB PF03308.16 EXF80691.1 - 0.013 14.5 0.4 0.037 13.0 0.3 1.8 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Arf PF00025.21 EXF80691.1 - 0.038 13.4 0.0 0.063 12.7 0.0 1.3 1 0 0 1 1 1 0 ADP-ribosylation factor family AAA_18 PF13238.6 EXF80691.1 - 0.084 13.4 0.1 0.31 11.6 0.0 1.9 2 0 0 2 2 2 0 AAA domain PHD PF00628.29 EXF80692.1 - 1.6e-09 37.5 2.3 3.5e-09 36.4 2.3 1.6 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 EXF80692.1 - 0.0013 18.3 3.1 0.0021 17.6 3.1 1.4 1 0 0 1 1 1 1 PHD-finger UIM PF02809.20 EXF80692.1 - 0.0017 18.1 3.4 0.0048 16.7 3.4 1.8 1 0 0 1 1 1 1 Ubiquitin interaction motif CEBP_ZZ PF16366.5 EXF80692.1 - 0.079 13.2 1.9 0.22 11.8 1.9 1.7 1 0 0 1 1 1 0 Cytoplasmic polyadenylation element-binding protein ZZ domain zf-CW PF07496.15 EXF80692.1 - 0.1 12.6 1.1 0.26 11.4 1.1 1.6 1 0 0 1 1 1 0 CW-type Zinc Finger ANAPC_CDC26 PF10471.9 EXF80693.1 - 1.3 9.9 6.9 4.9 8.1 0.5 3.0 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit CDC26 ATP-synt_E PF05680.12 EXF80693.1 - 7 7.1 12.2 2.8 8.3 4.4 2.5 2 0 0 2 2 2 0 ATP synthase E chain PHD PF00628.29 EXF80695.1 - 2.6e-05 24.0 8.4 4.6e-05 23.2 8.4 1.4 1 0 0 1 1 1 1 PHD-finger ING PF12998.7 EXF80695.1 - 0.0034 17.9 0.0 0.0094 16.5 0.0 1.8 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding zf-HC5HC2H PF13771.6 EXF80695.1 - 0.071 13.4 1.0 0.15 12.4 1.0 1.5 1 0 0 1 1 1 0 PHD-like zinc-binding domain AAA PF00004.29 EXF80696.1 - 1.3e-25 90.4 0.0 1.6e-13 51.2 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_6 PF17866.1 EXF80696.1 - 1.1e-10 41.5 5.2 2.6e-07 30.7 0.1 3.0 3 0 0 3 3 2 2 AAA lid domain AAA_5 PF07728.14 EXF80696.1 - 5.8e-08 32.8 0.2 0.0065 16.5 0.0 3.7 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 EXF80696.1 - 6.2e-07 29.3 0.1 0.072 12.8 0.1 3.3 2 2 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EXF80696.1 - 1.3e-05 25.5 9.1 0.052 13.8 0.6 4.7 3 2 0 4 4 3 2 AAA domain IstB_IS21 PF01695.17 EXF80696.1 - 3.9e-05 23.4 1.1 0.018 14.8 0.0 3.1 3 0 0 3 3 3 1 IstB-like ATP binding protein AAA_18 PF13238.6 EXF80696.1 - 4.2e-05 24.1 0.1 0.29 11.7 0.0 3.1 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.6 EXF80696.1 - 6.4e-05 23.3 0.3 0.35 11.2 0.0 3.2 2 1 1 3 3 3 2 AAA domain AAA_33 PF13671.6 EXF80696.1 - 0.00011 22.4 0.1 0.99 9.6 0.0 3.3 3 0 0 3 3 3 2 AAA domain Viral_helicase1 PF01443.18 EXF80696.1 - 0.00015 21.6 0.0 0.47 10.1 0.0 2.7 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase AAA_30 PF13604.6 EXF80696.1 - 0.00015 21.5 0.1 0.13 11.9 0.0 2.9 2 1 0 2 2 2 2 AAA domain Mg_chelatase PF01078.21 EXF80696.1 - 0.00016 21.1 0.1 0.66 9.3 0.1 2.8 2 1 0 2 2 2 2 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 EXF80696.1 - 0.00033 20.4 0.1 0.15 11.8 0.0 3.9 2 2 1 3 3 3 1 Sigma-54 interaction domain AAA_16 PF13191.6 EXF80696.1 - 0.00035 21.0 0.9 2.2 8.6 0.0 3.5 4 0 0 4 4 3 2 AAA ATPase domain TniB PF05621.11 EXF80696.1 - 0.00067 19.1 0.2 0.75 9.2 0.0 3.9 2 2 1 4 4 4 1 Bacterial TniB protein RNA_helicase PF00910.22 EXF80696.1 - 0.0019 18.6 0.1 2.2 8.7 0.0 3.0 3 0 0 3 3 2 1 RNA helicase AAA_24 PF13479.6 EXF80696.1 - 0.0024 17.6 0.1 1.9 8.2 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_28 PF13521.6 EXF80696.1 - 0.0026 18.0 0.1 1.6 8.9 0.1 2.7 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.6 EXF80696.1 - 0.0097 16.3 2.0 3.3 8.1 0.2 3.4 4 0 0 4 4 3 1 AAA domain AAA_11 PF13086.6 EXF80696.1 - 0.023 14.5 3.8 0.34 10.6 0.0 3.0 3 0 0 3 3 3 0 AAA domain Hydin_ADK PF17213.3 EXF80696.1 - 0.023 15.0 0.0 0.073 13.3 0.0 1.9 2 0 0 2 2 1 0 Hydin Adenylate kinase-like domain AAA_7 PF12775.7 EXF80696.1 - 0.063 12.8 1.2 7.5 6.0 0.1 2.9 2 2 1 3 3 3 0 P-loop containing dynein motor region NTPase_1 PF03266.15 EXF80696.1 - 0.091 12.7 0.8 8 6.3 0.0 3.0 2 1 0 2 2 2 0 NTPase Torsin PF06309.11 EXF80696.1 - 0.12 12.5 0.0 0.95 9.6 0.0 2.3 2 0 0 2 2 2 0 Torsin Bactofilin PF04519.13 EXF80697.1 - 4.6e-06 26.8 2.1 2.6e-05 24.4 1.9 2.1 1 1 0 1 1 1 1 Polymer-forming cytoskeletal MinC_C PF03775.16 EXF80697.1 - 0.0062 16.5 2.7 0.24 11.4 0.1 2.5 1 1 2 3 3 3 2 Septum formation inhibitor MinC, C-terminal domain FapA PF03961.13 EXF80697.1 - 0.016 13.9 3.3 0.077 11.6 3.3 1.9 1 1 0 1 1 1 0 Flagellar Assembly Protein A S_tail_recep_bd PF14928.6 EXF80697.1 - 0.026 15.1 0.0 0.069 13.8 0.0 1.7 1 1 0 1 1 1 0 Short tail fibre protein receptor-binding domain zf-C2H2 PF00096.26 EXF80699.1 - 0.013 15.9 3.2 0.041 14.3 3.2 1.9 1 0 0 1 1 1 0 Zinc finger, C2H2 type DUF1604 PF07713.13 EXF80699.1 - 0.036 13.9 2.9 0.11 12.4 2.9 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1604) DUF3602 PF12223.8 EXF80700.1 - 1.4e-10 41.6 26.6 2.5e-06 28.0 5.4 3.1 1 1 2 3 3 3 3 Protein of unknown function (DUF3602) Ribosomal_L24e PF01246.20 EXF80701.1 - 1.8e-31 108.2 6.2 3.7e-31 107.1 6.2 1.6 1 0 0 1 1 1 1 Ribosomal protein L24e DUF1974 PF09317.11 EXF80701.1 - 0.036 13.6 1.1 0.049 13.2 1.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1974) Pam16 PF03656.13 EXF80702.1 - 9.2e-07 28.9 0.0 1.1e-06 28.7 0.0 1.2 1 0 0 1 1 1 1 Pam16 DnaJ PF00226.31 EXF80702.1 - 5.5e-05 23.2 0.0 8.6e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 DnaJ domain DUF3918 PF13056.6 EXF80702.1 - 0.04 13.5 1.1 0.096 12.3 1.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3918) Ku_PK_bind PF08785.11 EXF80704.1 - 8.9e-34 116.2 0.0 2e-33 115.1 0.0 1.6 1 0 0 1 1 1 1 Ku C terminal domain like Ku PF02735.16 EXF80704.1 - 4.1e-30 105.0 0.0 7.3e-30 104.2 0.0 1.3 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_N PF03731.15 EXF80704.1 - 8.2e-11 42.1 0.0 1.9e-10 40.9 0.0 1.6 1 0 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain VWA PF00092.28 EXF80704.1 - 0.00011 22.6 0.1 0.00024 21.4 0.1 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain DUF2121 PF09894.9 EXF80704.1 - 0.022 14.3 0.0 0.047 13.2 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2121) Ku_C PF03730.14 EXF80704.1 - 0.067 13.9 0.3 0.21 12.3 0.0 2.0 2 0 0 2 2 2 0 Ku70/Ku80 C-terminal arm DUF4149 PF13664.6 EXF80705.1 - 2.7e-24 85.4 4.5 2.7e-24 85.4 4.5 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4149) DUF1772 PF08592.11 EXF80705.1 - 0.00038 20.8 0.7 0.00058 20.2 0.7 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF1772) Hydrolase_like PF13242.6 EXF80707.1 - 2.3e-17 62.8 0.1 2.5e-16 59.5 0.0 2.4 3 0 0 3 3 3 1 HAD-hyrolase-like Hydrolase_6 PF13344.6 EXF80707.1 - 5.6e-14 52.1 0.0 9.7e-14 51.3 0.0 1.4 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EXF80707.1 - 4.1e-06 27.2 0.0 6.2e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EXF80707.1 - 0.034 14.2 0.0 0.076 13.1 0.0 1.5 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase DUF1295 PF06966.12 EXF80708.1 - 7.1e-32 110.8 10.1 8.8e-32 110.5 10.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) ICMT PF04140.14 EXF80708.1 - 0.11 13.0 4.1 0.15 12.5 0.7 2.6 2 1 0 2 2 2 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family Topoisom_bac PF01131.20 EXF80709.1 - 2.8e-108 362.6 0.0 1.2e-101 340.8 0.0 2.0 2 0 0 2 2 2 2 DNA topoisomerase Toprim PF01751.22 EXF80709.1 - 2.2e-19 69.6 0.0 4.8e-19 68.5 0.0 1.6 1 0 0 1 1 1 1 Toprim domain Stb3 PF10330.9 EXF80710.1 - 1.6e-37 127.4 0.0 2.6e-37 126.7 0.0 1.3 1 0 0 1 1 1 1 Putative Sin3 binding protein SF1-HH PF16275.5 EXF80710.1 - 0.00034 20.9 0.1 0.0008 19.7 0.1 1.6 1 0 0 1 1 1 1 Splicing factor 1 helix-hairpin domain PD40 PF07676.12 EXF80711.1 - 5.9e-49 163.1 17.0 8.9e-07 28.7 0.0 9.7 9 0 0 9 9 9 9 WD40-like Beta Propeller Repeat ADH_zinc_N PF00107.26 EXF80711.1 - 2.1e-14 53.6 0.2 5.4e-14 52.3 0.2 1.8 1 0 0 1 1 1 1 Zinc-binding dehydrogenase DPPIV_N PF00930.21 EXF80711.1 - 2.1e-11 43.2 4.3 0.021 13.6 0.2 6.9 5 1 1 6 6 6 4 Dipeptidyl peptidase IV (DPP IV) N-terminal region ADH_zinc_N_2 PF13602.6 EXF80711.1 - 0.00023 22.2 0.0 0.00097 20.2 0.0 2.1 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EXF80711.1 - 0.00043 20.1 0.3 0.0021 17.9 0.2 2.1 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain TruB_C PF09142.11 EXF80711.1 - 0.032 14.0 0.0 40 4.1 0.0 4.6 5 0 0 5 5 5 0 tRNA Pseudouridine synthase II, C terminal DUF5050 PF16472.5 EXF80711.1 - 0.065 12.5 0.0 39 3.4 0.0 3.9 3 1 0 4 4 4 0 Domain of unknown function (DUF5050) WD40 PF00400.32 EXF80711.1 - 0.066 14.1 6.6 68 4.6 0.0 6.5 7 1 0 7 7 7 0 WD domain, G-beta repeat adh_short PF00106.25 EXF80712.1 - 9.8e-36 123.1 1.1 1.3e-35 122.7 1.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF80712.1 - 6.9e-25 88.0 0.3 8.7e-25 87.6 0.3 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF1776 PF08643.10 EXF80712.1 - 0.015 14.7 0.0 0.026 13.9 0.0 1.4 2 0 0 2 2 2 0 Fungal family of unknown function (DUF1776) NmrA PF05368.13 EXF80712.1 - 0.062 12.8 0.2 0.098 12.2 0.2 1.3 1 0 0 1 1 1 0 NmrA-like family 2-Hacid_dh_C PF02826.19 EXF80712.1 - 0.076 12.4 0.0 1.1 8.5 0.0 2.2 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ADH_N PF08240.12 EXF80713.1 - 1.1e-24 86.5 5.7 1.7e-24 85.8 5.7 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EXF80713.1 - 1.6e-15 57.2 0.1 2.5e-15 56.6 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EXF80713.1 - 0.0025 18.9 0.0 0.0046 18.0 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase NAD_binding_10 PF13460.6 EXF80713.1 - 0.06 13.2 0.2 0.096 12.6 0.2 1.3 1 0 0 1 1 1 0 NAD(P)H-binding ELFV_dehydrog PF00208.21 EXF80713.1 - 0.063 13.0 0.3 0.11 12.2 0.3 1.3 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase zf-C2H2 PF00096.26 EXF80715.1 - 3.4e-07 30.3 17.9 1.8e-05 25.0 3.7 3.8 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EXF80715.1 - 2.8e-05 24.6 11.8 4.4e-05 24.0 2.5 3.8 3 0 0 3 3 3 1 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EXF80715.1 - 3.4e-05 24.1 7.4 6.8e-05 23.1 4.2 2.8 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2_8 PF15909.5 EXF80715.1 - 0.00019 21.6 3.9 0.00058 20.1 3.9 1.8 1 0 0 1 1 1 1 C2H2-type zinc ribbon zf-C2H2_jaz PF12171.8 EXF80715.1 - 0.00065 19.9 1.1 0.00065 19.9 1.1 2.5 3 0 0 3 3 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 EXF80715.1 - 0.0097 15.9 2.3 0.03 14.3 2.3 1.8 1 0 0 1 1 1 1 C2H2-type zinc finger zf-met PF12874.7 EXF80715.1 - 0.013 15.8 1.9 0.14 12.6 0.8 2.6 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2HC_2 PF13913.6 EXF80715.1 - 0.25 11.3 1.8 0.57 10.1 1.8 1.6 1 0 0 1 1 1 0 zinc-finger of a C2HC-type zf-C2H2_aberr PF17017.5 EXF80715.1 - 0.33 11.1 4.4 0.97 9.6 4.4 1.8 1 1 0 1 1 1 0 Aberrant zinc-finger zf-TRAF PF02176.18 EXF80715.1 - 0.4 11.4 7.7 0.094 13.4 3.3 2.0 2 0 0 2 2 2 0 TRAF-type zinc finger FOXP-CC PF16159.5 EXF80715.1 - 0.42 11.3 7.0 2.6 8.7 0.3 3.4 1 1 2 3 3 3 0 FOXP coiled-coil domain ARS2 PF04959.13 EXF80715.1 - 0.91 9.9 4.2 1.4 9.2 2.1 2.3 2 0 0 2 2 2 0 Arsenite-resistance protein 2 zf-C2HE PF16278.5 EXF80715.1 - 2.6 8.5 5.3 7.9 7.0 5.3 1.9 1 1 0 1 1 1 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_2 PF12756.7 EXF80715.1 - 7.7 6.9 8.1 3.7 7.9 3.8 2.6 2 1 1 3 3 3 0 C2H2 type zinc-finger (2 copies) FMO-like PF00743.19 EXF80717.1 - 7.5e-16 57.6 0.8 1e-13 50.6 0.6 2.7 2 2 0 2 2 2 2 Flavin-binding monooxygenase-like K_oxygenase PF13434.6 EXF80717.1 - 2.2e-07 30.4 0.0 0.00012 21.3 0.0 3.4 4 0 0 4 4 4 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 EXF80717.1 - 3.7e-07 30.3 0.0 8.9e-07 29.1 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 EXF80717.1 - 8.7e-06 25.2 0.0 3.6e-05 23.2 0.0 2.0 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EXF80717.1 - 0.00012 21.4 0.0 0.097 11.9 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EXF80717.1 - 0.06 13.3 0.0 2.1 8.3 0.0 2.5 2 0 0 2 2 2 0 FAD-NAD(P)-binding MFS_1 PF07690.16 EXF80718.1 - 1.8e-31 109.4 26.0 1.9e-31 109.3 25.3 1.3 2 0 0 2 2 2 1 Major Facilitator Superfamily NAD_binding_2 PF03446.15 EXF80719.1 - 2.6e-18 66.7 0.0 6e-18 65.5 0.0 1.6 1 1 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 EXF80719.1 - 6.1e-10 39.4 0.0 1.2e-09 38.5 0.0 1.5 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase Fungal_trans PF04082.18 EXF80720.1 - 2.3e-10 39.9 2.9 3.9e-10 39.2 2.9 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 EXF80720.1 - 1.6e-05 25.1 11.9 3.2e-05 24.1 2.5 2.7 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EXF80720.1 - 0.00021 21.6 6.7 0.0088 16.4 1.4 2.5 2 0 0 2 2 2 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 EXF80720.1 - 0.014 16.2 1.5 0.014 16.2 1.5 3.2 3 0 0 3 3 2 0 C2H2-type zinc finger ERAP1_C PF11838.8 EXF80720.1 - 0.037 13.6 1.4 0.066 12.7 0.3 1.8 2 0 0 2 2 2 0 ERAP1-like C-terminal domain PGM_PMM_IV PF00408.20 EXF80720.1 - 0.16 12.2 0.7 8.5 6.6 0.1 2.5 2 0 0 2 2 2 0 Phosphoglucomutase/phosphomannomutase, C-terminal domain zf-C2H2_8 PF15909.5 EXF80720.1 - 0.23 11.8 3.8 0.53 10.6 3.8 1.6 1 0 0 1 1 1 0 C2H2-type zinc ribbon zf-C2H2_11 PF16622.5 EXF80720.1 - 0.32 10.8 2.5 19 5.2 0.2 2.5 2 0 0 2 2 2 0 zinc-finger C2H2-type zinc-ribbons_6 PF07191.12 EXF80720.1 - 0.92 9.5 4.5 1.7 8.7 4.5 1.4 1 0 0 1 1 1 0 zinc-ribbons zf-LYAR PF08790.11 EXF80720.1 - 0.96 9.4 5.4 0.58 10.1 0.4 2.4 2 0 0 2 2 2 0 LYAR-type C2HC zinc finger zf-C2H2_6 PF13912.6 EXF80720.1 - 0.98 9.5 7.0 0.54 10.3 1.1 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger LIM PF00412.22 EXF80720.1 - 3.2 8.0 5.8 39 4.6 1.2 2.8 3 0 0 3 3 3 0 LIM domain zf-met PF12874.7 EXF80720.1 - 3.5 8.1 5.9 6.2 7.4 0.5 2.5 2 0 0 2 2 2 0 Zinc-finger of C2H2 type ecTbetaR2 PF08917.10 EXF80721.1 - 0.14 12.1 2.4 0.26 11.3 2.4 1.4 1 0 0 1 1 1 0 Transforming growth factor beta receptor 2 ectodomain Thioredoxin_6 PF13848.6 EXF80722.1 - 8.3e-16 58.4 0.0 1.9e-11 44.2 0.0 2.3 1 1 1 2 2 2 2 Thioredoxin-like domain Thioredoxin PF00085.20 EXF80722.1 - 1.5e-08 34.5 0.0 1e-06 28.7 0.0 2.6 2 0 0 2 2 2 1 Thioredoxin HBM PF16591.5 EXF80722.1 - 0.11 11.9 0.0 0.24 10.8 0.0 1.5 1 0 0 1 1 1 0 Helical bimodular sensor domain SET PF00856.28 EXF80724.1 - 2.2e-07 31.4 0.0 7.3e-07 29.7 0.0 2.0 1 1 0 1 1 1 1 SET domain preATP-grasp_3 PF18301.1 EXF80724.1 - 0.042 14.1 0.0 0.15 12.3 0.0 2.0 1 0 0 1 1 1 0 pre ATP-grasp 3 domain zf-MYND PF01753.18 EXF80724.1 - 0.88 9.7 12.8 0.098 12.8 6.9 2.5 2 0 0 2 2 2 0 MYND finger Fungal_trans_2 PF11951.8 EXF80725.1 - 0.007 15.2 0.5 0.0094 14.8 0.5 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain RTA1 PF04479.13 EXF80726.1 - 2e-66 223.6 13.0 3e-66 223.0 13.0 1.3 1 0 0 1 1 1 1 RTA1 like protein MFS_1 PF07690.16 EXF80728.1 - 2.1e-20 72.9 45.3 5.7e-12 45.2 22.9 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_3 PF05977.13 EXF80728.1 - 0.058 11.8 18.3 0.1 11.0 3.7 2.1 2 0 0 2 2 2 0 Transmembrane secretion effector DUF3425 PF11905.8 EXF80730.1 - 0.0011 19.0 0.2 0.0022 17.9 0.2 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) DUF2730 PF10805.8 EXF80730.1 - 0.25 11.5 2.2 0.56 10.3 2.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2730) bZIP_1 PF00170.21 EXF80730.1 - 0.61 10.2 18.4 5.8 7.1 12.5 2.8 2 1 1 3 3 3 0 bZIP transcription factor Enkurin PF13864.6 EXF80730.1 - 2 8.9 7.9 1.3 9.5 5.4 2.0 2 0 0 2 2 2 0 Calmodulin-binding ABC_tran_Xtn PF12848.7 EXF80730.1 - 3.1 7.9 7.7 5.6 7.1 7.7 1.4 1 0 0 1 1 1 0 ABC transporter p450 PF00067.22 EXF80732.1 - 4.5e-39 134.5 0.0 1.5e-38 132.7 0.0 1.7 1 1 0 1 1 1 1 Cytochrome P450 Bac_rhamnosid6H PF17389.2 EXF80733.1 - 2.3e-117 392.1 0.0 2.9e-117 391.7 0.0 1.1 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain Bac_rhamnosid_N PF08531.10 EXF80733.1 - 1.1e-47 162.1 0.0 3.1e-47 160.6 0.0 1.7 2 0 0 2 2 2 1 Alpha-L-rhamnosidase N-terminal domain Bac_rhamnosid PF05592.11 EXF80733.1 - 1.3e-25 89.3 0.0 2.3e-25 88.5 0.0 1.4 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase concanavalin-like domain Bac_rhamnosid_C PF17390.2 EXF80733.1 - 1.9e-18 66.0 1.0 3e-18 65.4 0.1 1.8 2 0 0 2 2 2 1 Bacterial alpha-L-rhamnosidase C-terminal domain Sugar_tr PF00083.24 EXF80734.1 - 2.5e-89 300.2 28.5 2.8e-89 300.1 28.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF80734.1 - 1.1e-29 103.5 40.4 1.7e-28 99.6 33.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EXF80734.1 - 4.2e-06 25.5 4.5 4.2e-06 25.5 4.5 2.1 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Epimerase PF01370.21 EXF80735.1 - 2.6e-17 63.1 0.0 3.4e-17 62.7 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EXF80735.1 - 7.7e-10 38.7 0.0 1.1e-09 38.2 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 EXF80735.1 - 4.6e-09 35.7 0.0 6e-09 35.3 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 EXF80735.1 - 7.5e-06 25.2 0.0 1.1e-05 24.7 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.12 EXF80735.1 - 3.7e-05 23.0 0.1 0.1 11.8 0.1 2.4 2 1 0 2 2 2 2 Male sterility protein NAD_binding_10 PF13460.6 EXF80735.1 - 0.0014 18.6 0.0 0.0024 17.8 0.0 1.5 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EXF80737.1 - 1.5e-32 113.0 0.0 1.9e-32 112.7 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EXF80737.1 - 3.4e-06 27.1 0.0 5.9e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 EXF80737.1 - 0.012 14.6 0.0 0.017 14.2 0.0 1.1 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family PAP2_3 PF14378.6 EXF80738.1 - 2.6e-23 82.7 16.7 1.9e-18 66.8 3.2 2.6 3 0 0 3 3 3 2 PAP2 superfamily RtcB PF01139.17 EXF80738.1 - 0.012 14.9 0.0 0.017 14.3 0.0 1.2 1 0 0 1 1 1 0 tRNA-splicing ligase RtcB ThrE PF06738.12 EXF80738.1 - 0.076 12.4 0.0 0.14 11.5 0.0 1.4 1 0 0 1 1 1 0 Putative threonine/serine exporter Fungal_trans PF04082.18 EXF80739.1 - 9e-10 38.0 0.1 2.2e-09 36.8 0.0 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain SKA2 PF16740.5 EXF80739.1 - 0.086 12.6 0.1 0.89 9.4 0.0 2.3 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 2 Glyco_hydro_3_C PF01915.22 EXF80740.1 - 5.4e-49 166.9 0.2 2.1e-48 165.0 0.2 2.0 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 EXF80740.1 - 4.8e-38 131.3 0.0 8.4e-38 130.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 EXF80740.1 - 2e-18 66.2 0.0 4.2e-18 65.2 0.0 1.6 1 0 0 1 1 1 1 Fibronectin type III-like domain DUF1823 PF08853.11 EXF80740.1 - 0.18 12.0 0.0 13 6.0 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF1823) ERG4_ERG24 PF01222.17 EXF80741.1 - 2e-166 554.1 0.6 2.3e-166 553.9 0.6 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.12 EXF80741.1 - 0.00015 21.3 0.2 0.00044 19.9 0.2 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) Man-6-P_recep PF02157.15 EXF80742.1 - 8.4e-17 61.1 0.0 3.9e-16 58.9 0.0 1.8 2 0 0 2 2 2 1 Mannose-6-phosphate receptor ATG27 PF09451.10 EXF80742.1 - 3.5e-14 53.3 0.0 5.5e-14 52.7 0.0 1.4 1 1 0 1 1 1 1 Autophagy-related protein 27 CIMR PF00878.18 EXF80742.1 - 3.3e-09 37.0 0.2 3.5e-05 23.9 0.0 2.3 2 0 0 2 2 2 2 Cation-independent mannose-6-phosphate receptor repeat Aldo_ket_red PF00248.21 EXF80743.1 - 1e-43 149.6 0.0 9.2e-42 143.2 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family HET PF06985.11 EXF80744.1 - 9.9e-14 51.9 2.6 1.4e-12 48.2 2.6 2.2 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) bZIP_2 PF07716.15 EXF80745.1 - 7.6e-06 25.9 12.3 1.3e-05 25.2 12.3 1.4 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 EXF80745.1 - 6e-05 23.1 9.4 9.6e-05 22.4 9.4 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_Maf PF03131.17 EXF80745.1 - 0.017 15.7 6.0 0.017 15.7 6.0 1.6 2 0 0 2 2 2 0 bZIP Maf transcription factor DUF641 PF04859.12 EXF80745.1 - 0.033 14.5 2.3 0.047 14.0 2.3 1.2 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) SlyX PF04102.12 EXF80745.1 - 0.13 12.9 2.5 0.29 11.8 2.5 1.6 1 0 0 1 1 1 0 SlyX GrpE PF01025.19 EXF80745.1 - 0.27 10.9 4.4 0.37 10.4 4.4 1.3 1 0 0 1 1 1 0 GrpE PKcGMP_CC PF16808.5 EXF80745.1 - 0.36 10.7 5.5 1.1 9.1 1.2 2.4 1 1 1 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase XhlA PF10779.9 EXF80745.1 - 1.5 9.1 7.2 0.2 11.9 2.9 1.7 2 0 0 2 2 2 0 Haemolysin XhlA NmrA PF05368.13 EXF80746.1 - 1.5e-20 73.8 0.6 2.4e-20 73.1 0.6 1.4 1 1 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EXF80746.1 - 6.7e-19 68.5 0.0 1.1e-18 67.7 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 EXF80746.1 - 3.3e-06 27.4 2.4 0.0095 16.2 0.2 2.2 2 0 0 2 2 2 2 Saccharopine dehydrogenase NADP binding domain Epimerase PF01370.21 EXF80746.1 - 7.8e-06 25.5 0.2 1.2e-05 24.9 0.2 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family F420_oxidored PF03807.17 EXF80746.1 - 0.00019 21.9 0.8 0.00045 20.8 0.2 1.9 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent adh_short PF00106.25 EXF80746.1 - 0.00037 20.0 0.3 0.00083 18.9 0.3 1.6 1 0 0 1 1 1 1 short chain dehydrogenase CoA_binding_2 PF13380.6 EXF80746.1 - 0.0035 17.8 0.7 0.51 10.8 0.2 2.3 2 0 0 2 2 2 1 CoA binding domain RmlD_sub_bind PF04321.17 EXF80746.1 - 0.0089 15.1 0.1 0.013 14.6 0.1 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain LpxI_N PF17930.1 EXF80746.1 - 0.014 15.3 0.3 0.056 13.3 0.1 2.0 2 0 0 2 2 2 0 LpxI N-terminal domain NAD_binding_2 PF03446.15 EXF80746.1 - 0.025 14.8 0.7 0.043 14.0 0.2 1.7 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase Semialdhyde_dh PF01118.24 EXF80746.1 - 0.037 14.4 1.9 0.057 13.9 0.7 1.8 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain NAD_binding_7 PF13241.6 EXF80746.1 - 0.045 14.2 0.7 0.11 13.0 0.7 1.6 1 0 0 1 1 1 0 Putative NAD(P)-binding 3Beta_HSD PF01073.19 EXF80746.1 - 0.064 12.3 0.2 0.1 11.6 0.2 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family 3HCDH_N PF02737.18 EXF80746.1 - 0.099 12.5 2.3 0.077 12.9 0.6 1.7 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DapB_N PF01113.20 EXF80746.1 - 0.12 12.5 1.9 0.22 11.7 0.4 2.2 2 1 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus Acetyltransf_7 PF13508.7 EXF80747.1 - 5.3e-08 33.2 0.1 2.8e-07 30.9 0.1 2.0 1 1 1 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EXF80747.1 - 6e-07 29.7 0.0 9.2e-07 29.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EXF80747.1 - 9e-06 25.6 0.0 1.4e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain MOZ_SAS PF01853.18 EXF80747.1 - 0.069 12.8 0.0 0.11 12.1 0.0 1.2 1 0 0 1 1 1 0 MOZ/SAS family OAM_dimer PF16554.5 EXF80747.1 - 0.17 12.4 0.0 0.32 11.5 0.0 1.4 1 0 0 1 1 1 0 Dimerisation domain of d-ornithine 4,5-aminomutase Dioxygenase_C PF00775.21 EXF80748.1 - 0.00018 21.0 0.0 0.00055 19.4 0.0 1.9 1 1 0 1 1 1 1 Dioxygenase MAPEG PF01124.18 EXF80750.1 - 1.5e-20 73.4 0.1 1.7e-20 73.2 0.1 1.0 1 0 0 1 1 1 1 MAPEG family Serglycin PF04360.12 EXF80752.1 - 0.02 14.9 0.9 0.023 14.6 0.9 1.2 1 0 0 1 1 1 0 Serglycin MFS_1 PF07690.16 EXF80754.1 - 1.8e-37 129.1 28.0 1.8e-37 129.1 28.0 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_3 PF05977.13 EXF80754.1 - 0.00053 18.5 0.6 0.00089 17.8 0.6 1.4 1 0 0 1 1 1 1 Transmembrane secretion effector TRI12 PF06609.13 EXF80754.1 - 0.0015 17.0 5.4 0.0015 17.0 5.4 1.6 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) HrpB7 PF09486.10 EXF80756.1 - 0.0017 18.7 1.9 0.023 15.1 0.6 2.1 2 0 0 2 2 2 1 Bacterial type III secretion protein (HrpB7) FGase PF05013.12 EXF80756.1 - 0.022 15.0 0.0 0.031 14.5 0.0 1.2 1 0 0 1 1 1 0 N-formylglutamate amidohydrolase Katanin_con80 PF13925.6 EXF80756.1 - 0.047 13.7 0.1 0.078 13.0 0.1 1.5 1 0 0 1 1 1 0 con80 domain of Katanin DUF3802 PF12290.8 EXF80756.1 - 0.056 13.9 0.1 0.09 13.3 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3802) RSN1_7TM PF02714.15 EXF80757.1 - 1.2e-84 283.8 12.7 1.2e-84 283.8 12.7 2.4 2 0 0 2 2 2 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 EXF80757.1 - 9.6e-40 135.9 6.2 3.1e-39 134.2 6.2 2.0 1 0 0 1 1 1 1 Late exocytosis, associated with Golgi transport PHM7_ext PF12621.8 EXF80757.1 - 2.4e-30 104.5 0.2 1.4e-28 98.9 0.1 2.4 2 0 0 2 2 2 1 Extracellular tail, of 10TM putative phosphate transporter PHM7_cyt PF14703.6 EXF80757.1 - 3.5e-27 95.8 0.0 5.2e-27 95.2 0.0 1.3 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter RRM_1 PF00076.22 EXF80757.1 - 0.0085 15.9 0.0 0.02 14.7 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Transferase PF02458.15 EXF80758.1 - 2.2e-08 33.2 0.0 4e-07 29.0 0.0 2.6 2 1 0 2 2 2 1 Transferase family TauD PF02668.16 EXF80759.1 - 1.3e-53 182.6 0.3 1.4e-53 182.4 0.3 1.0 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family 2OG-FeII_Oxy_3 PF13640.6 EXF80759.1 - 0.021 15.7 0.3 0.96 10.4 0.3 2.4 1 1 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily F-box-like PF12937.7 EXF80760.1 - 3.4e-06 26.8 0.1 0.0026 17.6 0.0 3.5 3 0 0 3 3 3 2 F-box-like Fungal_trans PF04082.18 EXF80761.1 - 5.3e-39 133.9 0.0 8.7e-39 133.2 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Aminotran_5 PF00266.19 EXF80761.1 - 1e-30 107.0 0.0 7.8e-30 104.1 0.0 2.2 2 1 0 2 2 2 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 EXF80761.1 - 0.036 13.2 0.0 0.071 12.3 0.0 1.4 1 0 0 1 1 1 0 Aminotransferase class I and II Zn_clus PF00172.18 EXF80761.1 - 0.073 13.2 14.5 0.2 11.8 14.5 1.7 1 1 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain CVNH PF08881.10 EXF80763.1 - 1.2e-24 86.9 1.0 1.8e-24 86.4 1.0 1.3 1 0 0 1 1 1 1 CVNH domain Ribosomal_L50 PF10501.9 EXF80765.1 - 9.2e-17 61.2 0.3 1.8e-16 60.2 0.0 1.6 2 0 0 2 2 2 1 Ribosomal subunit 39S SAP PF02037.27 EXF80765.1 - 0.039 13.7 0.0 0.096 12.5 0.0 1.6 1 0 0 1 1 1 0 SAP domain TORC_M PF12885.7 EXF80765.1 - 0.14 12.0 0.1 0.33 10.9 0.1 1.6 1 0 0 1 1 1 0 Transducer of regulated CREB activity middle domain DAHP_synth_1 PF00793.20 EXF80767.1 - 2.6e-103 344.7 0.1 3.2e-103 344.4 0.1 1.0 1 0 0 1 1 1 1 DAHP synthetase I family COX14 PF14880.6 EXF80769.1 - 3e-21 75.0 1.1 5.3e-21 74.2 0.3 1.9 2 0 0 2 2 2 1 Cytochrome oxidase c assembly PRP4 PF08799.11 EXF80769.1 - 0.069 12.7 0.4 0.14 11.7 0.4 1.5 1 0 0 1 1 1 0 pre-mRNA processing factor 4 (PRP4) like Hamartin PF04388.12 EXF80769.1 - 5.2 5.6 11.1 9 4.8 11.1 1.3 1 1 0 1 1 1 0 Hamartin protein Ribosomal_L13e PF01294.18 EXF80770.1 - 2.1e-76 255.8 2.1 2.8e-76 255.4 2.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L13e BAF250_C PF12031.8 EXF80771.1 - 0.12 11.7 0.2 5.8 6.1 0.0 3.2 2 1 0 2 2 2 0 SWI/SNF-like complex subunit BAF250/Osa Sugar_tr PF00083.24 EXF80773.1 - 3.5e-81 273.4 22.9 4.3e-81 273.1 22.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF80773.1 - 6.2e-31 107.6 55.3 5.6e-25 88.0 30.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EXF80773.1 - 0.00013 20.6 1.7 0.00013 20.6 1.7 2.3 2 1 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Aldo_ket_red PF00248.21 EXF80774.1 - 1.3e-69 234.7 0.1 1.6e-69 234.4 0.1 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family FMO-like PF00743.19 EXF80775.1 - 6.3e-57 193.2 0.0 1.4e-56 192.1 0.0 1.5 1 1 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EXF80775.1 - 1.3e-13 50.8 0.0 8.5e-11 41.7 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EXF80775.1 - 5.9e-09 35.6 0.0 1.7e-07 30.8 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EXF80775.1 - 2.4e-08 34.0 0.1 0.018 14.7 0.0 3.3 2 1 0 3 3 3 2 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EXF80775.1 - 6.3e-08 32.8 0.1 0.0041 17.1 0.0 4.1 3 1 0 3 3 3 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 EXF80775.1 - 1.1e-07 31.9 0.0 3.5e-07 30.3 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 EXF80775.1 - 2.5e-07 30.2 0.6 1.3e-05 24.6 0.0 2.8 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Amino_oxidase PF01593.24 EXF80775.1 - 0.0012 18.2 0.5 0.23 10.7 0.0 3.8 4 1 0 5 5 5 1 Flavin containing amine oxidoreductase Pyr_redox PF00070.27 EXF80775.1 - 0.0016 18.9 0.0 0.072 13.7 0.0 2.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EXF80775.1 - 0.005 16.1 0.1 0.07 12.4 0.1 2.2 2 0 0 2 2 2 1 FAD binding domain Thi4 PF01946.17 EXF80775.1 - 0.021 14.1 0.0 0.032 13.5 0.0 1.2 1 0 0 1 1 1 0 Thi4 family IlvN PF07991.12 EXF80775.1 - 0.095 12.3 0.0 0.23 11.0 0.0 1.6 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain Shikimate_DH PF01488.20 EXF80775.1 - 0.2 11.7 0.0 2.2 8.3 0.0 2.3 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase DUF1593 PF07632.11 EXF80776.1 - 3e-95 318.5 0.0 3.8e-95 318.2 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1593) REJ PF02010.15 EXF80776.1 - 0.061 12.1 0.0 0.089 11.6 0.0 1.2 1 0 0 1 1 1 0 REJ domain Sugar_tr PF00083.24 EXF80777.1 - 1.3e-69 235.2 18.9 1.5e-69 235.0 18.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF80777.1 - 8.6e-18 64.4 24.0 8.6e-18 64.4 24.0 2.1 1 1 2 3 3 3 1 Major Facilitator Superfamily MFS_1_like PF12832.7 EXF80777.1 - 0.00097 18.1 5.6 0.19 10.6 1.5 3.0 1 1 1 2 2 2 2 MFS_1 like family MFS_1 PF07690.16 EXF80778.1 - 7.8e-39 133.6 39.1 7.8e-39 133.6 39.1 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF80778.1 - 1.9e-14 53.4 12.7 1.9e-14 53.4 12.7 2.7 2 2 0 2 2 2 1 Sugar (and other) transporter Fungal_trans PF04082.18 EXF80779.1 - 5.3e-13 48.6 0.0 8.1e-13 48.0 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF80779.1 - 3.2e-07 30.4 9.9 5.8e-07 29.5 9.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain p450 PF00067.22 EXF80781.1 - 6.8e-52 176.7 0.0 9.7e-52 176.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Tox-HDC PF15656.6 EXF80781.1 - 0.026 14.7 0.0 0.047 13.9 0.0 1.4 1 0 0 1 1 1 0 Toxin with a H, D/N and C signature Exo_endo_phos PF03372.23 EXF80783.1 - 1.2e-07 31.5 1.9 1.8e-07 31.0 1.9 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Methyltransf_23 PF13489.6 EXF80784.1 - 7.1e-18 65.0 0.0 1.7e-17 63.7 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF80784.1 - 2.1e-10 41.2 0.0 6e-10 39.7 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF80784.1 - 2.3e-09 37.7 0.0 4.5e-09 36.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF80784.1 - 5.7e-07 29.4 0.0 0.022 14.5 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 EXF80784.1 - 6.6e-06 26.8 0.0 8.2e-05 23.3 0.0 2.4 2 1 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 EXF80784.1 - 0.014 14.9 0.0 0.055 13.0 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_2 PF00891.18 EXF80784.1 - 0.022 14.1 0.0 0.038 13.3 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase domain Ubie_methyltran PF01209.18 EXF80784.1 - 0.022 14.1 0.0 0.27 10.5 0.0 2.4 2 1 0 2 2 2 0 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.17 EXF80784.1 - 0.027 13.9 0.0 0.088 12.3 0.0 1.8 2 0 0 2 2 2 0 Putative methyltransferase PrmA PF06325.13 EXF80784.1 - 0.049 13.0 0.0 0.081 12.3 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_2 PF00891.18 EXF80785.1 - 1.6e-13 50.5 0.0 3.2e-13 49.5 0.0 1.5 1 1 0 1 1 1 1 O-methyltransferase domain NAD_binding_4 PF07993.12 EXF80788.1 - 6.9e-36 123.7 0.0 1.1e-35 123.1 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein AMP-binding PF00501.28 EXF80788.1 - 1.9e-34 119.0 0.0 3.1e-34 118.3 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme Epimerase PF01370.21 EXF80788.1 - 1.1e-12 47.9 0.0 2.7e-12 46.7 0.0 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family PP-binding PF00550.25 EXF80788.1 - 5.1e-07 30.0 0.0 1.1e-06 28.9 0.0 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site GDP_Man_Dehyd PF16363.5 EXF80788.1 - 0.0022 17.5 0.0 0.019 14.4 0.0 2.0 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase KR PF08659.10 EXF80788.1 - 0.0073 16.2 0.1 0.017 15.1 0.1 1.6 1 1 0 1 1 1 1 KR domain 3Beta_HSD PF01073.19 EXF80788.1 - 0.0083 15.2 0.0 0.15 11.0 0.0 2.0 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Semialdhyde_dh PF01118.24 EXF80788.1 - 0.14 12.6 0.0 0.53 10.7 0.0 2.1 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain Dak1 PF02733.17 EXF80789.1 - 9.7e-108 359.7 1.9 1.4e-107 359.2 1.9 1.2 1 0 0 1 1 1 1 Dak1 domain Dak2 PF02734.17 EXF80789.1 - 1.1e-45 155.6 5.1 1.1e-45 155.6 5.1 1.7 2 0 0 2 2 2 1 DAK2 domain ACT_7 PF13840.6 EXF80789.1 - 0.11 12.3 0.0 0.33 10.8 0.0 1.8 1 0 0 1 1 1 0 ACT domain Fungal_trans PF04082.18 EXF80790.1 - 1.4e-28 99.7 0.2 2.2e-28 99.1 0.2 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF80790.1 - 9e-08 32.1 9.8 9e-08 32.1 9.8 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Cyclase PF04199.13 EXF80791.1 - 3.1e-14 53.4 0.0 4.3e-14 52.9 0.0 1.2 1 0 0 1 1 1 1 Putative cyclase MFS_1 PF07690.16 EXF80792.1 - 1.2e-27 96.8 20.9 2.4e-27 95.8 21.2 1.3 1 1 0 1 1 1 1 Major Facilitator Superfamily DHDPS PF00701.22 EXF80793.1 - 7.7e-29 100.3 0.0 9.4e-29 100.0 0.0 1.1 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family DUF818 PF05677.12 EXF80793.1 - 0.075 12.0 0.0 0.11 11.4 0.0 1.2 1 0 0 1 1 1 0 Chlamydia CHLPS protein (DUF818) Aldo_ket_red PF00248.21 EXF80794.1 - 1.8e-55 188.2 0.1 1.3e-54 185.4 0.1 1.9 1 1 0 1 1 1 1 Aldo/keto reductase family MR_MLE_C PF13378.6 EXF80795.1 - 2.8e-61 206.9 0.1 3.8e-61 206.5 0.1 1.1 1 0 0 1 1 1 1 Enolase C-terminal domain-like MR_MLE_N PF02746.16 EXF80795.1 - 2e-16 60.3 0.0 4.1e-16 59.2 0.0 1.5 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain Amidohydro_2 PF04909.14 EXF80795.1 - 0.063 13.0 0.1 0.18 11.5 0.1 1.7 2 0 0 2 2 2 0 Amidohydrolase Citrate_synt PF00285.21 EXF80797.1 - 3.2e-122 408.1 0.0 4.1e-122 407.7 0.0 1.1 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain NmrA PF05368.13 EXF80798.1 - 1e-21 77.6 1.0 3.7e-21 75.7 1.0 1.8 1 1 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EXF80798.1 - 3.1e-19 69.6 0.1 1.3e-18 67.6 0.1 1.9 1 1 0 1 1 1 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 EXF80798.1 - 1.8e-08 34.7 2.5 4.5e-07 30.2 0.0 2.7 2 1 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain Epimerase PF01370.21 EXF80798.1 - 1.7e-07 30.9 0.0 3.5e-07 29.9 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family DapB_N PF01113.20 EXF80798.1 - 1.1e-05 25.5 0.4 0.00077 19.6 0.1 2.4 2 0 0 2 2 2 1 Dihydrodipicolinate reductase, N-terminus Semialdhyde_dh PF01118.24 EXF80798.1 - 2.8e-05 24.5 1.2 6.6e-05 23.3 0.0 2.2 3 0 0 3 3 3 1 Semialdehyde dehydrogenase, NAD binding domain RmlD_sub_bind PF04321.17 EXF80798.1 - 5.1e-05 22.5 0.3 0.00031 20.0 0.1 1.9 2 0 0 2 2 2 1 RmlD substrate binding domain 3HCDH_N PF02737.18 EXF80798.1 - 0.00015 21.7 0.8 0.00023 21.1 0.1 1.7 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DFP PF04127.15 EXF80798.1 - 0.00023 21.1 1.3 0.001 18.9 0.1 2.1 2 0 0 2 2 2 1 DNA / pantothenate metabolism flavoprotein Shikimate_DH PF01488.20 EXF80798.1 - 0.00031 20.8 0.3 0.00079 19.5 0.0 1.7 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase NAD_binding_2 PF03446.15 EXF80798.1 - 0.0021 18.2 0.3 0.02 15.1 0.0 2.3 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase IlvN PF07991.12 EXF80798.1 - 0.0027 17.3 0.1 0.0067 16.0 0.1 1.6 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain 3Beta_HSD PF01073.19 EXF80798.1 - 0.003 16.6 0.2 0.008 15.2 0.0 1.8 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family F420_oxidored PF03807.17 EXF80798.1 - 0.009 16.6 1.3 0.026 15.1 0.1 2.3 2 1 1 3 3 3 1 NADP oxidoreductase coenzyme F420-dependent GDP_Man_Dehyd PF16363.5 EXF80798.1 - 0.0094 15.4 0.7 0.014 14.8 0.0 1.6 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase adh_short PF00106.25 EXF80798.1 - 0.023 14.1 1.4 0.039 13.4 0.1 1.9 2 0 0 2 2 2 0 short chain dehydrogenase TrkA_N PF02254.18 EXF80798.1 - 0.059 13.6 0.0 0.13 12.5 0.0 1.7 1 0 0 1 1 1 0 TrkA-N domain 2-Hacid_dh_C PF02826.19 EXF80798.1 - 0.08 12.3 0.0 0.15 11.4 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Ldh_1_N PF00056.23 EXF80798.1 - 0.09 12.9 0.3 0.22 11.6 0.1 1.8 2 0 0 2 2 2 0 lactate/malate dehydrogenase, NAD binding domain Cation_ATPase_C PF00689.21 EXF80799.1 - 1.7e-40 138.7 5.0 1.7e-40 138.7 5.0 2.6 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 EXF80799.1 - 1.2e-37 129.2 2.5 1.2e-37 129.2 2.5 1.8 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase PF13246.6 EXF80799.1 - 1.5e-20 73.1 0.0 3.6e-20 71.8 0.0 1.7 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EXF80799.1 - 7.4e-18 65.6 0.0 6.3e-17 62.6 0.0 2.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EXF80799.1 - 6.2e-09 35.4 0.1 4.9e-08 32.5 0.0 2.4 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EXF80799.1 - 1.7e-05 24.7 0.2 0.00019 21.2 0.6 2.1 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF1295 PF06966.12 EXF80799.1 - 0.018 14.6 0.2 0.24 10.9 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1295) DUF3792 PF12670.7 EXF80799.1 - 1.3 9.2 8.0 3.1 8.0 3.4 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3792) Glyco_hydro_61 PF03443.14 EXF80800.1 - 7.5e-56 189.3 0.1 1.3e-55 188.5 0.1 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 Fungal_trans PF04082.18 EXF80800.1 - 2e-13 50.0 0.0 3.1e-13 49.4 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain CBM_1 PF00734.18 EXF80800.1 - 5.2e-06 26.3 8.7 2.1e-05 24.4 8.7 2.1 1 0 0 1 1 1 1 Fungal cellulose binding domain Zn_clus PF00172.18 EXF80800.1 - 0.0027 17.8 8.9 0.0027 17.8 8.9 2.1 3 0 0 3 3 3 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Abhydrolase_3 PF07859.13 EXF80801.1 - 1.4e-55 188.5 0.0 1.9e-55 188.0 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 EXF80801.1 - 1e-05 24.7 0.1 3.3e-05 23.0 0.1 1.7 1 1 0 1 1 1 1 Carboxylesterase family Peptidase_S9 PF00326.21 EXF80801.1 - 0.00029 20.4 0.0 0.084 12.3 0.0 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 EXF80801.1 - 0.0029 18.2 0.9 0.0044 17.7 0.4 1.5 2 0 0 2 2 2 1 Alpha/beta hydrolase family Esterase_phd PF10503.9 EXF80801.1 - 0.0049 16.4 0.1 0.0097 15.4 0.1 1.4 1 0 0 1 1 1 1 Esterase PHB depolymerase PTR2 PF00854.21 EXF80802.1 - 1e-51 176.0 11.3 5.9e-37 127.4 1.9 2.3 3 0 0 3 3 3 2 POT family RseC_MucC PF04246.12 EXF80802.1 - 0.016 15.1 4.0 1.2 9.1 0.0 3.0 3 0 0 3 3 3 0 Positive regulator of sigma(E), RseC/MucC Pex14_N PF04695.13 EXF80803.1 - 3.9 8.1 16.4 1.2 9.8 0.6 2.4 2 1 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region TMEM171 PF15471.6 EXF80803.1 - 8.7 5.2 7.2 4 6.4 5.0 1.7 1 1 0 1 1 1 0 Transmembrane protein family 171 p450 PF00067.22 EXF80804.1 - 1.6e-59 201.9 0.0 3.4e-59 200.8 0.0 1.5 1 1 0 1 1 1 1 Cytochrome P450 TauD PF02668.16 EXF80806.1 - 1.1e-12 48.4 0.1 1.8e-09 37.8 0.0 2.2 1 1 1 2 2 2 2 Taurine catabolism dioxygenase TauD, TfdA family GH131_N PF18271.1 EXF80808.1 - 1.9e-82 276.8 1.1 2.2e-82 276.6 1.1 1.0 1 0 0 1 1 1 1 Glycoside hydrolase 131 catalytic N-terminal domain AA_kinase PF00696.28 EXF80809.1 - 2.7e-35 122.1 0.0 6e-35 121.0 0.0 1.6 2 0 0 2 2 2 1 Amino acid kinase family ACT_7 PF13840.6 EXF80809.1 - 7.9e-13 48.0 4.2 8.3e-11 41.5 3.6 2.5 2 0 0 2 2 2 2 ACT domain ACT PF01842.25 EXF80809.1 - 1.7e-05 24.4 0.8 7.2e-05 22.5 0.3 2.2 2 0 0 2 2 2 1 ACT domain SecD-TM1 PF13721.6 EXF80809.1 - 0.17 12.4 0.2 4.5 7.8 0.0 2.5 2 0 0 2 2 2 0 SecD export protein N-terminal TM region Abhydrolase_1 PF00561.20 EXF80810.1 - 1.5e-40 139.5 0.0 1.9e-40 139.1 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EXF80810.1 - 0.00019 22.1 2.3 0.00041 21.0 2.3 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family CN_hydrolase PF00795.22 EXF80811.1 - 3.6e-55 187.1 0.0 8.3e-55 185.9 0.0 1.5 1 1 0 1 1 1 1 Carbon-nitrogen hydrolase Cys_Met_Meta_PP PF01053.20 EXF80812.1 - 5.3e-141 469.6 0.0 7.3e-141 469.1 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 EXF80812.1 - 6.3e-08 32.2 0.1 1.1e-07 31.4 0.1 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 EXF80812.1 - 8e-08 31.6 0.1 1.3e-07 30.9 0.1 1.3 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 EXF80812.1 - 5e-07 29.3 0.0 1.2e-06 28.1 0.0 1.6 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.21 EXF80812.1 - 0.0004 19.7 0.0 0.0013 18.0 0.0 1.9 2 0 0 2 2 2 1 Beta-eliminating lyase SepSecS PF05889.13 EXF80812.1 - 0.0006 18.6 0.3 0.0053 15.5 0.1 2.0 2 0 0 2 2 2 1 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS Met_gamma_lyase PF06838.11 EXF80812.1 - 0.033 12.7 0.0 0.052 12.1 0.0 1.2 1 0 0 1 1 1 0 Methionine gamma-lyase Fungal_trans PF04082.18 EXF80812.1 - 0.033 13.2 0.2 0.087 11.8 0.2 1.8 1 1 0 1 1 1 0 Fungal specific transcription factor domain GDC-P PF02347.16 EXF80812.1 - 0.034 13.0 0.0 0.064 12.1 0.0 1.4 1 0 0 1 1 1 0 Glycine cleavage system P-protein BRK PF07533.16 EXF80812.1 - 0.16 11.6 1.2 1.1 8.9 0.4 2.3 2 0 0 2 2 2 0 BRK domain Protoglobin PF11563.8 EXF80813.1 - 4.7e-58 195.6 0.1 5.7e-58 195.3 0.1 1.1 1 0 0 1 1 1 1 Protoglobin ABC1 PF03109.16 EXF80815.1 - 6.4e-23 81.2 0.1 1.5e-13 51.0 0.0 2.9 3 0 0 3 3 3 2 ABC1 family APH PF01636.23 EXF80815.1 - 0.0092 15.9 1.3 0.045 13.7 0.1 2.6 1 1 1 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.22 EXF80815.1 - 0.058 13.0 0.0 0.3 10.6 0.0 2.0 2 0 0 2 2 2 0 RIO1 family Cyto_heme_lyase PF01265.17 EXF80816.1 - 3.1e-115 384.8 4.7 1.2e-113 379.5 4.7 2.0 1 1 0 1 1 1 1 Cytochrome c/c1 heme lyase CbtB PF09489.10 EXF80816.1 - 1.5 9.0 4.4 21 5.3 0.2 2.5 2 0 0 2 2 2 0 Probable cobalt transporter subunit (CbtB) Tme5_EGF_like PF09064.10 EXF80819.1 - 0.13 12.2 4.2 0.29 11.1 4.2 1.6 1 0 0 1 1 1 0 Thrombomodulin like fifth domain, EGF-like Phage_fiber_2 PF03406.13 EXF80821.1 - 0.091 12.3 0.3 0.15 11.6 0.3 1.3 1 0 0 1 1 1 0 Phage tail fibre repeat TMEM247 PF15444.6 EXF80822.1 - 0.17 11.9 0.4 0.32 11.0 0.4 1.4 1 0 0 1 1 1 0 Transmembrane protein 247 F-box-like PF12937.7 EXF80823.1 - 3.2e-09 36.5 2.3 4.1e-09 36.2 0.2 2.4 3 0 0 3 3 3 1 F-box-like F-box PF00646.33 EXF80823.1 - 0.072 13.0 2.1 1.9 8.5 2.1 3.0 1 1 0 1 1 1 0 F-box domain GCR1_C PF12550.8 EXF80824.1 - 2.6e-18 66.1 0.0 5.7e-18 65.0 0.0 1.6 1 0 0 1 1 1 1 Transcriptional activator of glycolytic enzymes Glyco_hydro_3_C PF01915.22 EXF80825.1 - 2.4e-46 158.3 0.0 3.9e-46 157.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 EXF80825.1 - 2.2e-35 122.6 0.0 4.1e-35 121.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 EXF80825.1 - 3.7e-21 75.0 0.0 6.7e-21 74.2 0.0 1.4 1 0 0 1 1 1 1 Fibronectin type III-like domain Glyoxalase PF00903.25 EXF80826.1 - 6.9e-11 42.4 0.0 1.8e-10 41.1 0.0 1.6 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 EXF80826.1 - 1.5e-08 34.8 0.0 1.9e-08 34.6 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 EXF80826.1 - 8.5e-06 26.5 0.0 2.1e-05 25.3 0.0 1.6 1 1 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_3 PF13468.6 EXF80826.1 - 0.0063 16.6 0.0 0.45 10.6 0.0 2.1 2 0 0 2 2 2 1 Glyoxalase-like domain CagD PF16567.5 EXF80826.1 - 0.13 12.0 0.1 0.17 11.6 0.1 1.2 1 0 0 1 1 1 0 Pathogenicity island component CagD Sugar_tr PF00083.24 EXF80827.1 - 1.3e-128 429.8 23.5 1.5e-128 429.5 23.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF80827.1 - 4e-25 88.5 40.6 1.2e-19 70.5 15.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily YqfD PF06898.11 EXF80827.1 - 0.12 11.2 1.7 1.6 7.4 0.0 2.3 2 0 0 2 2 2 0 Putative stage IV sporulation protein YqfD SBP_bac_11 PF13531.6 EXF80828.1 - 2.4e-06 27.5 0.0 3.8e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 EXF80828.1 - 2.2e-05 24.6 2.5 4.3e-05 23.6 2.5 1.5 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_6 PF13343.6 EXF80828.1 - 2.3e-05 24.0 0.2 3.7e-05 23.3 0.2 1.4 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein HsbA PF12296.8 EXF80829.1 - 3.4e-23 82.3 10.5 3.4e-23 82.3 10.5 1.7 2 0 0 2 2 2 1 Hydrophobic surface binding protein A Bep_C_terminal PF17841.1 EXF80830.1 - 0.035 14.3 0.6 8.5 6.7 0.1 2.9 3 0 0 3 3 3 0 BID domain of Bartonella effector protein (Bep) DbpA PF03880.15 EXF80831.1 - 0.0085 16.1 0.0 0.017 15.1 0.0 1.5 1 0 0 1 1 1 1 DbpA RNA binding domain RRM_1 PF00076.22 EXF80831.1 - 0.11 12.3 0.0 0.25 11.2 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Peptidase_U57 PF05582.12 EXF80831.1 - 7 5.8 8.3 19 4.4 8.1 1.8 1 1 0 1 1 1 0 YabG peptidase U57 MFS_1 PF07690.16 EXF80832.1 - 2.1e-30 105.9 25.4 3.1e-30 105.3 25.4 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF3054 PF11255.8 EXF80832.1 - 0.18 12.3 7.0 0.4 11.2 1.7 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF3054) PEMT PF04191.13 EXF80832.1 - 0.2 12.1 4.1 2.8 8.4 0.2 3.4 1 1 2 3 3 3 0 Phospholipid methyltransferase Saf_2TM PF18303.1 EXF80832.1 - 4 7.0 12.3 0.11 12.1 1.3 3.2 4 0 0 4 4 4 0 SAVED-fused 2TM effector domain MAPEG PF01124.18 EXF80832.1 - 4.7 7.1 8.8 0.13 12.1 0.6 2.7 4 0 0 4 4 4 0 MAPEG family HXXEE PF13787.6 EXF80832.1 - 9.8 7.0 11.5 1 10.2 1.1 3.1 2 2 0 2 2 2 0 Protein of unknown function with HXXEE motif Sugar_tr PF00083.24 EXF80833.1 - 6.4e-92 308.8 22.7 7.9e-92 308.5 22.7 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF80833.1 - 1.6e-12 47.1 41.8 1.1e-09 37.7 33.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Vps62 PF06101.11 EXF80834.1 - 3.1e-11 42.3 3.5 7.1e-11 41.1 0.2 2.5 3 0 0 3 3 3 2 Vacuolar protein sorting-associated protein 62 Ank_2 PF12796.7 EXF80835.1 - 4.5e-33 113.7 2.6 6.9e-12 45.8 0.1 4.3 2 1 3 5 5 5 5 Ankyrin repeats (3 copies) NACHT_N PF17100.5 EXF80835.1 - 6.3e-25 88.3 0.0 1.7e-24 87.0 0.0 1.7 2 0 0 2 2 2 1 N-terminal domain of NWD NACHT-NTPase Ank_5 PF13857.6 EXF80835.1 - 1.2e-22 79.6 10.7 2.9e-08 33.8 0.5 5.9 2 2 3 5 5 5 5 Ankyrin repeats (many copies) Ank_4 PF13637.6 EXF80835.1 - 1.1e-20 73.7 6.0 4.5e-06 27.1 0.0 6.4 4 1 2 6 6 6 4 Ankyrin repeats (many copies) Ank PF00023.30 EXF80835.1 - 2.4e-16 59.3 6.1 0.0078 16.6 0.1 6.8 7 0 0 7 7 7 4 Ankyrin repeat Ank_3 PF13606.6 EXF80835.1 - 4.6e-11 41.9 6.2 0.034 14.7 0.0 7.3 9 0 0 9 9 9 3 Ankyrin repeat NACHT PF05729.12 EXF80835.1 - 1.3e-06 28.5 0.1 3.3e-06 27.1 0.1 1.7 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 EXF80835.1 - 9.7e-05 22.8 0.2 0.001 19.4 0.0 2.9 3 0 0 3 3 3 1 AAA ATPase domain AAA_18 PF13238.6 EXF80835.1 - 0.0013 19.2 0.0 2.2 8.8 0.0 2.9 1 1 1 2 2 2 2 AAA domain UBA_4 PF14555.6 EXF80835.1 - 0.052 13.4 0.1 0.16 11.8 0.1 1.8 1 0 0 1 1 1 0 UBA-like domain Neur_chan_memb PF02932.16 EXF80836.1 - 2.5 8.1 11.8 1.1 9.3 6.6 2.4 1 1 1 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region PNTB_4TM PF12769.7 EXF80837.1 - 0.024 15.1 0.2 0.037 14.5 0.2 1.2 1 0 0 1 1 1 0 4TM region of pyridine nucleotide transhydrogenase, mitoch DUF2306 PF10067.9 EXF80837.1 - 0.25 11.5 1.8 0.4 10.9 1.8 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2306) COesterase PF00135.28 EXF80838.1 - 4e-89 299.8 0.1 5.1e-89 299.5 0.1 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EXF80838.1 - 2.6e-05 24.2 0.1 0.00011 22.2 0.1 2.0 2 1 0 2 2 2 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EXF80838.1 - 0.0018 17.8 0.0 0.0033 16.9 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Crystall_3 PF08964.10 EXF80840.1 - 0.087 13.0 0.1 0.13 12.4 0.1 1.3 1 0 0 1 1 1 0 Beta/Gamma crystallin Yeast-kill-tox PF09207.11 EXF80840.1 - 0.25 12.0 5.2 0.35 11.6 4.7 1.5 1 1 0 1 1 1 0 Yeast killer toxin Rtt106 PF08512.12 EXF80841.1 - 0.0074 16.7 0.0 0.015 15.7 0.0 1.4 1 0 0 1 1 1 1 Histone chaperone Rttp106-like Glyco_hydr_30_2 PF14587.6 EXF80843.1 - 6.9e-17 62.1 11.8 4.1e-16 59.5 9.5 2.7 2 1 0 2 2 2 1 O-Glycosyl hydrolase family 30 Glyco_hydro_59 PF02057.15 EXF80843.1 - 1.2e-09 37.9 5.2 2.5e-09 36.8 4.0 1.8 2 0 0 2 2 2 1 Glycosyl hydrolase family 59 zf-C2H2 PF00096.26 EXF80846.1 - 0.029 14.8 1.6 0.055 13.9 1.6 1.5 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-C2H2 PF00096.26 EXF80848.1 - 0.23 12.0 0.2 0.46 11.0 0.2 1.5 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EXF80848.1 - 0.24 12.4 0.2 0.43 11.5 0.2 1.5 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2_4 PF13894.6 EXF80850.1 - 0.85 10.6 2.2 1.7 9.7 2.2 1.5 1 0 0 1 1 1 0 C2H2-type zinc finger CENP-O PF09496.10 EXF80851.1 - 0.078 13.0 3.6 0.1 12.6 3.6 1.2 1 0 0 1 1 1 0 Cenp-O kinetochore centromere component NinG PF05766.12 EXF80851.1 - 0.34 10.8 5.4 0.52 10.2 5.4 1.4 1 1 0 1 1 1 0 Bacteriophage Lambda NinG protein bZIP_1 PF00170.21 EXF80853.1 - 0.00016 21.7 3.6 0.00016 21.7 3.6 1.9 2 1 0 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.15 EXF80853.1 - 0.00028 20.9 1.5 0.00028 20.9 1.5 2.0 3 0 0 3 3 3 1 Basic region leucine zipper DUF1484 PF07363.11 EXF80853.1 - 0.2 12.7 2.4 0.25 12.3 1.2 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1484) HpcH_HpaI PF03328.14 EXF80854.1 - 3.8e-20 72.0 0.0 6.7e-20 71.2 0.0 1.3 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family DUF892 PF05974.12 EXF80855.1 - 0.012 15.6 0.1 0.017 15.2 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF892) Ank_2 PF12796.7 EXF80856.1 - 1e-24 86.9 4.7 3.3e-08 34.0 0.2 5.1 3 1 2 5 5 5 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EXF80856.1 - 3.4e-21 75.3 8.5 1.2e-06 29.0 0.3 6.1 3 1 4 7 7 7 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EXF80856.1 - 5.7e-17 60.1 7.2 0.22 12.2 0.0 8.6 9 0 0 9 9 9 6 Ankyrin repeat Ank_5 PF13857.6 EXF80856.1 - 1.4e-15 57.2 6.6 0.0004 20.6 0.0 6.5 2 2 5 7 7 7 6 Ankyrin repeats (many copies) Ank PF00023.30 EXF80856.1 - 8.5e-13 48.1 7.8 0.26 11.8 0.0 8.0 8 0 0 8 8 8 4 Ankyrin repeat HET PF06985.11 EXF80856.1 - 2.7e-12 47.3 2.7 2.6e-09 37.6 0.1 2.4 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) GMC_oxred_N PF00732.19 EXF80857.1 - 5e-29 101.6 0.0 8.9e-29 100.8 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EXF80857.1 - 2.6e-21 76.7 0.6 5.7e-21 75.6 0.6 1.6 1 0 0 1 1 1 1 GMC oxidoreductase Pyr_redox_2 PF07992.14 EXF80857.1 - 2.2e-06 27.1 0.5 8.8e-05 21.9 0.0 3.3 3 1 1 4 4 4 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EXF80857.1 - 1.8e-05 24.3 0.0 9e-05 22.0 0.1 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase HI0933_like PF03486.14 EXF80857.1 - 3.6e-05 22.6 1.4 0.00019 20.3 0.1 2.5 3 0 0 3 3 3 1 HI0933-like protein NAD_binding_8 PF13450.6 EXF80857.1 - 0.00016 21.8 0.0 0.00063 19.9 0.0 2.1 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EXF80857.1 - 0.00064 18.9 0.5 0.00064 18.9 0.5 2.2 3 0 0 3 3 3 1 FAD binding domain GIDA PF01134.22 EXF80857.1 - 0.0028 16.8 0.1 0.0048 16.0 0.1 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A DAO PF01266.24 EXF80857.1 - 0.0071 16.0 4.0 0.09 12.3 4.0 2.2 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 EXF80857.1 - 0.024 13.9 0.0 0.04 13.1 0.0 1.4 1 0 0 1 1 1 0 FAD binding domain Lycopene_cycl PF05834.12 EXF80857.1 - 0.033 13.3 0.0 0.049 12.7 0.0 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein Pyr_redox PF00070.27 EXF80857.1 - 0.036 14.6 0.3 0.15 12.7 0.2 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EXF80857.1 - 0.057 12.7 0.1 0.14 11.4 0.0 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EXF80857.1 - 0.1 11.5 0.1 0.15 10.9 0.1 1.2 1 0 0 1 1 1 0 Tryptophan halogenase Actin PF00022.19 EXF80860.1 - 7.1e-76 255.4 0.0 4.1e-74 249.6 0.0 2.1 1 1 0 1 1 1 1 Actin F-box PF00646.33 EXF80860.1 - 4.1e-05 23.3 0.0 9.7e-05 22.1 0.0 1.6 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EXF80860.1 - 0.0001 22.1 0.0 0.00027 20.8 0.0 1.7 1 0 0 1 1 1 1 F-box-like PHD_Oberon PF07227.11 EXF80860.1 - 0.065 13.1 0.2 0.12 12.3 0.2 1.3 1 0 0 1 1 1 0 PHD - plant homeodomain finger protein DUF2177 PF09945.9 EXF80860.1 - 2.9 8.0 9.1 1.6 8.8 0.2 2.9 3 0 0 3 3 3 0 Predicted membrane protein (DUF2177) Histone PF00125.24 EXF80862.1 - 1.6e-17 64.1 0.0 2.1e-17 63.7 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Histone_H2A_C PF16211.5 EXF80862.1 - 1.1e-12 47.4 0.8 1.9e-12 46.7 0.1 1.8 2 0 0 2 2 2 1 C-terminus of histone H2A CBFD_NFYB_HMF PF00808.23 EXF80862.1 - 6.3e-05 23.2 0.0 9.7e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone R3H PF01424.22 EXF80864.1 - 1.1e-09 38.2 0.2 2e-09 37.3 0.2 1.4 1 0 0 1 1 1 1 R3H domain RRM_1 PF00076.22 EXF80864.1 - 1.4e-05 24.8 0.0 4.2e-05 23.3 0.0 1.8 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_2 PF04059.12 EXF80864.1 - 0.052 13.8 0.0 0.11 12.8 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif 2 Mre11_DNA_bind PF04152.14 EXF80865.1 - 1.2e-53 181.9 0.4 1.2e-53 181.9 0.4 2.0 2 0 0 2 2 2 1 Mre11 DNA-binding presumed domain Metallophos PF00149.28 EXF80865.1 - 1.1e-15 58.7 2.3 2.3e-15 57.7 2.3 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EXF80865.1 - 0.00029 21.1 0.0 0.0022 18.2 0.0 2.4 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Peptidase_M43 PF05572.13 EXF80866.1 - 2.3e-16 60.0 1.0 3e-16 59.7 0.2 1.7 2 0 0 2 2 2 1 Pregnancy-associated plasma protein-A Reprolysin_3 PF13582.6 EXF80866.1 - 8.7e-06 26.3 0.0 1.6e-05 25.4 0.0 1.5 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 EXF80866.1 - 3.3e-05 24.1 3.0 7.5e-05 23.0 2.8 1.7 1 1 1 2 2 2 1 Metallo-peptidase family M12 Reprolysin_4 PF13583.6 EXF80866.1 - 0.00014 21.6 1.0 0.00017 21.3 1.0 1.4 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 EXF80866.1 - 0.00018 21.5 1.5 0.0011 18.9 0.2 2.1 2 0 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.24 EXF80866.1 - 0.0096 15.8 0.0 0.025 14.4 0.0 1.4 1 1 0 1 1 1 1 Matrixin DUF4953 PF16313.5 EXF80866.1 - 0.013 14.7 0.0 0.026 13.7 0.0 1.4 1 0 0 1 1 1 0 Met-zincin Peptidase_M54 PF07998.11 EXF80866.1 - 0.013 15.4 0.0 0.025 14.6 0.0 1.4 1 0 0 1 1 1 0 Peptidase family M54 Peptidase_M66 PF10462.9 EXF80866.1 - 0.014 14.4 1.9 0.023 13.7 2.0 1.4 1 1 0 1 1 1 0 Peptidase M66 RecT PF03837.14 EXF80866.1 - 0.11 12.0 0.0 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 RecT family Metallopep PF12044.8 EXF80866.1 - 0.16 10.5 1.4 0.35 9.4 0.6 1.7 2 0 0 2 2 2 0 Putative peptidase family Beta-lactamase PF00144.24 EXF80867.1 - 1.2e-25 90.4 0.3 1.4e-24 86.9 0.3 2.0 1 1 0 1 1 1 1 Beta-lactamase Peptidase_M28 PF04389.17 EXF80868.1 - 5.2e-38 130.7 0.0 7.4e-38 130.2 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 EXF80868.1 - 6.3e-09 35.8 0.2 1.2e-08 35.0 0.2 1.6 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 Nicastrin PF05450.15 EXF80868.1 - 0.016 14.7 0.1 0.32 10.4 0.0 2.2 2 0 0 2 2 2 0 Nicastrin Colipase PF01114.18 EXF80869.1 - 0.12 12.0 3.9 0.21 11.3 3.9 1.3 1 0 0 1 1 1 0 Colipase, N-terminal domain Kelch_5 PF13854.6 EXF80870.1 - 1.8e-05 24.6 1.3 0.4 10.7 0.0 4.0 4 1 0 4 4 4 2 Kelch motif Kelch_6 PF13964.6 EXF80870.1 - 0.011 16.0 6.4 19 5.7 0.0 5.4 6 0 0 6 6 6 0 Kelch motif Kelch_2 PF07646.15 EXF80870.1 - 0.87 9.7 9.9 1.1 9.3 0.4 4.9 4 2 0 4 4 4 0 Kelch motif Kelch_4 PF13418.6 EXF80870.1 - 1.3 9.0 8.3 57 3.8 0.0 5.4 6 0 0 6 6 6 0 Galactose oxidase, central domain MFS_1 PF07690.16 EXF80872.1 - 1.3e-17 63.7 31.7 4.3e-13 48.9 13.7 2.2 2 1 1 3 3 3 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF80872.1 - 1.8e-06 27.1 2.8 1.8e-06 27.1 2.8 2.7 2 1 1 3 3 3 1 Sugar (and other) transporter SH3_6 PF12913.7 EXF80872.1 - 0.027 14.0 0.1 0.068 12.7 0.1 1.7 1 0 0 1 1 1 0 SH3 domain (SH3b1 type) Syntaxin_2 PF14523.6 EXF80872.1 - 1.3 9.5 3.9 2.1 8.8 3.9 1.3 1 0 0 1 1 1 0 Syntaxin-like protein K_oxygenase PF13434.6 EXF80873.1 - 2.9e-08 33.2 0.0 4.1e-08 32.8 0.0 1.1 1 0 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.6 EXF80873.1 - 3.2e-08 33.2 0.0 8.5e-08 31.8 0.0 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 EXF80873.1 - 4.5e-08 32.0 0.0 1.7e-07 30.1 0.0 1.7 2 0 0 2 2 2 1 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 EXF80873.1 - 0.015 14.6 0.0 0.16 11.2 0.0 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Kinesin PF00225.23 EXF80875.1 - 1.9e-52 178.3 0.0 3e-52 177.6 0.0 1.4 1 1 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EXF80875.1 - 3e-07 30.5 0.0 4.9e-07 29.8 0.0 1.4 1 0 0 1 1 1 1 Microtubule binding AAA_16 PF13191.6 EXF80875.1 - 0.021 15.2 0.1 0.061 13.7 0.1 1.9 1 1 1 2 2 2 0 AAA ATPase domain COesterase PF00135.28 EXF80876.1 - 1.8e-92 310.9 0.0 2.3e-92 310.5 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EXF80876.1 - 2.4e-08 34.1 0.1 5.1e-07 29.8 0.1 2.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EXF80876.1 - 0.0049 16.4 0.1 0.0089 15.5 0.1 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family PAPS_reduct PF01507.19 EXF80877.1 - 9.3e-30 103.9 0.0 5.3e-21 75.4 0.0 2.2 1 1 1 2 2 2 2 Phosphoadenosine phosphosulfate reductase family DegS PF05384.11 EXF80877.1 - 0.057 12.9 0.0 0.082 12.4 0.0 1.1 1 0 0 1 1 1 0 Sensor protein DegS adh_short PF00106.25 EXF80879.1 - 4.7e-39 133.9 0.1 5.8e-39 133.6 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF80879.1 - 2.6e-26 92.6 0.1 3.6e-26 92.2 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF80879.1 - 1.2e-06 28.5 0.1 1.7e-06 28.0 0.1 1.2 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 EXF80879.1 - 0.0001 21.8 0.0 0.00012 21.6 0.0 1.1 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) Epimerase PF01370.21 EXF80879.1 - 0.00013 21.5 0.1 0.00028 20.4 0.1 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EXF80879.1 - 0.00085 18.5 0.0 0.0014 17.8 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.6 EXF80879.1 - 0.0011 18.9 0.1 0.0017 18.3 0.1 1.3 1 0 0 1 1 1 1 NAD(P)H-binding RmlD_sub_bind PF04321.17 EXF80879.1 - 0.029 13.5 0.1 0.041 13.0 0.1 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain DUF4863 PF16155.5 EXF80881.1 - 4.5e-70 234.4 0.0 5.3e-70 234.2 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4863) DUF1737 PF08410.10 EXF80881.1 - 0.059 13.2 1.0 0.17 11.8 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1737) Hydrolase_4 PF12146.8 EXF80882.1 - 8.2e-11 41.6 0.1 2.3e-06 27.0 0.1 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EXF80882.1 - 6.3e-08 32.6 0.1 0.0019 17.9 0.1 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EXF80882.1 - 8e-08 33.1 2.8 1.5e-07 32.3 2.8 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family LIP PF03583.14 EXF80882.1 - 0.0014 18.0 0.7 0.085 12.2 0.3 2.1 2 0 0 2 2 2 2 Secretory lipase DLH PF01738.18 EXF80882.1 - 0.074 12.6 0.0 9.5 5.7 0.0 2.2 2 0 0 2 2 2 0 Dienelactone hydrolase family DUF3425 PF11905.8 EXF80883.1 - 1.6e-18 66.8 0.2 4.2e-18 65.5 0.1 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF3425) Aldo_ket_red PF00248.21 EXF80884.1 - 6.3e-43 147.0 0.0 4.7e-42 144.2 0.0 1.9 1 1 0 1 1 1 1 Aldo/keto reductase family UTP15_C PF09384.10 EXF80885.1 - 0.056 13.1 0.1 0.15 11.8 0.1 1.6 1 0 0 1 1 1 0 UTP15 C terminal FliJ PF02050.16 EXF80885.1 - 1.3 9.3 5.7 2.8 8.2 0.4 2.7 2 1 1 3 3 3 0 Flagellar FliJ protein MFS_1 PF07690.16 EXF80886.1 - 2.5e-41 141.8 47.8 9.7e-41 139.9 46.3 2.2 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF80886.1 - 3.3e-11 42.7 12.2 3.3e-11 42.7 12.2 2.7 2 1 1 3 3 3 2 Sugar (and other) transporter TRI12 PF06609.13 EXF80886.1 - 4.4e-11 41.9 21.6 3.6e-10 38.9 21.6 2.2 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) RdRP PF05183.12 EXF80887.1 - 6.6e-160 533.6 0.0 3.4e-98 329.8 0.0 2.2 1 1 1 2 2 2 2 RNA dependent RNA polymerase Abhydrolase_1 PF00561.20 EXF80888.1 - 2.9e-13 50.1 0.0 1.3e-12 47.9 0.0 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Ndr PF03096.14 EXF80888.1 - 9.3e-11 40.9 0.0 1.3e-10 40.4 0.0 1.2 1 0 0 1 1 1 1 Ndr family Abhydrolase_6 PF12697.7 EXF80888.1 - 1.5e-10 42.1 0.1 2.7e-10 41.2 0.1 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EXF80888.1 - 2.5e-06 26.9 0.0 1.3e-05 24.6 0.0 2.0 1 1 0 1 1 1 1 Serine aminopeptidase, S33 EthD PF07110.11 EXF80888.1 - 5.9e-05 24.1 0.1 0.3 12.2 0.0 2.9 2 1 0 2 2 2 2 EthD domain DUF4286 PF14114.6 EXF80888.1 - 0.0032 17.9 0.0 1.3 9.5 0.0 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4286) Esterase PF00756.20 EXF80888.1 - 0.084 12.5 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 Putative esterase Como_LCP PF02247.16 EXF80888.1 - 0.13 10.8 0.0 0.21 10.2 0.0 1.2 1 0 0 1 1 1 0 Large coat protein Glyco_hydro_61 PF03443.14 EXF80889.1 - 1.6e-62 211.1 0.7 2e-62 210.8 0.7 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 Serglycin PF04360.12 EXF80889.1 - 0.01 15.8 7.8 0.02 14.8 7.8 1.4 1 0 0 1 1 1 0 Serglycin Zn_clus PF00172.18 EXF80890.1 - 1.1e-05 25.5 12.2 2e-05 24.6 12.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Sugar_tr PF00083.24 EXF80894.1 - 1e-19 70.8 2.9 1.1e-19 70.6 2.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter Cas6b_C PF17262.2 EXF80894.1 - 0.014 15.5 0.0 0.055 13.6 0.0 1.8 2 0 0 2 2 2 0 Cas6b C-terminal domain DUF809 PF05663.11 EXF80894.1 - 0.16 12.1 0.0 0.25 11.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF809) Sulfatase PF00884.23 EXF80895.1 - 1e-69 235.3 0.0 1.3e-69 234.9 0.0 1.1 1 0 0 1 1 1 1 Sulfatase DUF4976 PF16347.5 EXF80895.1 - 0.00011 22.4 0.1 0.00031 21.0 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4976) Phosphodiest PF01663.22 EXF80895.1 - 0.0083 15.7 0.0 1.1 8.7 0.0 2.3 2 0 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase_C PF14707.6 EXF80895.1 - 0.014 16.1 0.5 0.37 11.5 0.5 2.5 1 1 0 1 1 1 0 C-terminal region of aryl-sulfatase DUF229 PF02995.17 EXF80895.1 - 0.038 12.6 0.0 0.056 12.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF229) DUF4994 PF16385.5 EXF80895.1 - 0.18 11.7 0.1 0.55 10.2 0.1 1.8 1 1 0 1 1 1 0 Domain of unknown function TILa PF12714.7 EXF80897.1 - 0.16 12.0 0.7 0.23 11.5 0.7 1.2 1 0 0 1 1 1 0 TILa domain DUF2235 PF09994.9 EXF80898.1 - 2.5e-29 102.5 0.0 2.7e-29 102.5 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) Palm_thioest PF02089.15 EXF80898.1 - 0.026 14.3 0.0 0.035 13.9 0.0 1.2 1 0 0 1 1 1 0 Palmitoyl protein thioesterase FSH1 PF03959.13 EXF80898.1 - 0.13 11.9 0.0 0.21 11.2 0.0 1.3 1 0 0 1 1 1 0 Serine hydrolase (FSH1) RTA1 PF04479.13 EXF80899.1 - 2.6e-41 141.5 3.1 5.1e-30 104.6 1.8 2.3 2 0 0 2 2 2 2 RTA1 like protein p450 PF00067.22 EXF80899.1 - 7.9e-36 123.8 0.0 1.8e-35 122.6 0.0 1.5 1 1 0 1 1 1 1 Cytochrome P450 NARP1 PF12569.8 EXF80899.1 - 0.032 13.2 6.8 0.034 13.1 4.7 1.8 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 DUF2062 PF09835.9 EXF80899.1 - 0.16 11.9 5.5 0.23 11.3 3.9 2.1 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2062) Iso_dh PF00180.20 EXF80900.1 - 1.3e-106 356.7 0.0 1.5e-106 356.5 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Aminotran_4 PF01063.19 EXF80901.1 - 2.3e-20 73.4 0.0 3e-20 73.1 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV DUF2937 PF11157.8 EXF80901.1 - 0.0025 17.5 0.1 0.011 15.4 0.1 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF2937) Aconitase PF00330.20 EXF80902.1 - 3.1e-76 257.3 0.2 2e-74 251.3 0.2 2.1 1 1 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 EXF80902.1 - 3.8e-11 43.4 0.0 7.2e-11 42.5 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain Aconitase_2_N PF06434.13 EXF80902.1 - 0.00042 20.0 0.0 0.0007 19.3 0.0 1.3 1 0 0 1 1 1 1 Aconitate hydratase 2 N-terminus DUF3558 PF12079.8 EXF80902.1 - 0.05 13.6 0.1 0.16 12.0 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3558) Ank_2 PF12796.7 EXF80903.1 - 3e-19 69.4 1.1 7.6e-15 55.3 0.2 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EXF80903.1 - 9.2e-16 56.4 0.1 0.00033 20.9 0.0 3.6 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.6 EXF80903.1 - 1.6e-15 57.3 0.1 2.4e-09 37.5 0.1 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 EXF80903.1 - 9e-15 54.4 3.2 6.1e-06 26.4 0.9 3.5 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.6 EXF80903.1 - 3.8e-12 46.2 0.2 7.7e-07 29.3 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Sigma54_CBD PF04963.13 EXF80903.1 - 0.17 11.7 0.0 0.27 11.1 0.0 1.2 1 0 0 1 1 1 0 Sigma-54 factor, core binding domain p450 PF00067.22 EXF80904.1 - 2.1e-53 181.8 0.0 2.7e-53 181.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Polysacc_deac_1 PF01522.21 EXF80905.1 - 3.6e-12 46.3 0.0 5.5e-12 45.7 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase DUF2334 PF10096.9 EXF80905.1 - 3e-06 27.1 0.0 8.4e-06 25.6 0.0 1.8 2 0 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2334) Aminotran_5 PF00266.19 EXF80906.1 - 1.2e-56 192.3 0.0 1.6e-56 191.8 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 EXF80906.1 - 7.5e-06 24.7 0.0 9.3e-06 24.4 0.0 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 EXF80906.1 - 2.7e-05 23.5 0.1 4e-05 23.0 0.1 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 EXF80906.1 - 0.0026 17.2 0.1 0.0054 16.1 0.2 1.5 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family HMGL-like PF00682.19 EXF80907.1 - 3e-65 220.4 0.0 4.8e-65 219.7 0.0 1.2 1 0 0 1 1 1 1 HMGL-like MFS_1 PF07690.16 EXF80908.1 - 2e-41 142.1 48.7 3.7e-41 141.2 46.7 2.2 2 1 0 2 2 2 1 Major Facilitator Superfamily AMP-binding PF00501.28 EXF80909.1 - 2.5e-289 958.7 0.0 4.3e-78 262.8 0.0 4.3 4 0 0 4 4 4 4 AMP-binding enzyme Condensation PF00668.20 EXF80909.1 - 2.9e-162 540.5 0.0 9.1e-47 159.8 0.0 4.5 4 0 0 4 4 4 4 Condensation domain PP-binding PF00550.25 EXF80909.1 - 3.7e-51 171.3 0.4 6e-12 45.8 0.0 5.4 5 0 0 5 5 5 4 Phosphopantetheine attachment site AMP-binding_C PF13193.6 EXF80909.1 - 2.9e-13 50.6 0.9 0.014 16.3 0.0 5.4 5 0 0 5 5 5 4 AMP-binding enzyme C-terminal domain Fungal_trans_2 PF11951.8 EXF80910.1 - 5.2e-13 48.6 2.9 2.4e-12 46.4 3.0 1.8 1 1 0 1 1 1 1 Fungal specific transcription factor domain PEP_mutase PF13714.6 EXF80911.1 - 1.7e-46 158.6 0.7 3.1e-46 157.8 0.4 1.5 1 1 1 2 2 2 1 Phosphoenolpyruvate phosphomutase ICL PF00463.21 EXF80911.1 - 1.9e-13 49.8 0.1 2.6e-13 49.3 0.1 1.1 1 0 0 1 1 1 1 Isocitrate lyase family Pantoate_transf PF02548.15 EXF80911.1 - 0.008 15.6 0.0 0.038 13.4 0.0 1.9 2 0 0 2 2 2 1 Ketopantoate hydroxymethyltransferase DAHP_synth_1 PF00793.20 EXF80911.1 - 0.052 12.4 0.0 2.1 7.2 0.0 2.5 3 0 0 3 3 3 0 DAHP synthetase I family MFS_1 PF07690.16 EXF80913.1 - 2e-28 99.4 25.5 2.2e-28 99.2 25.5 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily TFIID_30kDa PF03540.13 EXF80914.1 - 2.2e-25 88.3 0.3 2.2e-25 88.3 0.3 1.5 2 0 0 2 2 2 1 Transcription initiation factor TFIID 23-30kDa subunit Ribosomal_S19 PF00203.21 EXF80915.1 - 4.2e-28 97.0 0.0 5.1e-28 96.8 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S19 Cellulase PF00150.18 EXF80916.1 - 3.4e-48 164.5 2.5 4.3e-48 164.2 2.5 1.0 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) DUF4038 PF13204.6 EXF80916.1 - 0.00056 19.6 0.1 0.00082 19.1 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF4038) Pho88 PF10032.9 EXF80917.1 - 5.8e-81 270.1 0.1 6.7e-81 269.9 0.1 1.0 1 0 0 1 1 1 1 Phosphate transport (Pho88) AnkUBD PF18418.1 EXF80917.1 - 0.08 13.1 0.0 0.17 12.1 0.0 1.6 1 1 0 1 1 1 0 Ankyrin ubiquitin-binding domain XPA_C PF05181.12 EXF80918.1 - 7.1e-26 89.9 2.3 2e-25 88.5 2.3 1.8 1 0 0 1 1 1 1 XPA protein C-terminus XPA_N PF01286.18 EXF80918.1 - 0.00084 19.3 2.8 0.00084 19.3 2.8 1.9 2 0 0 2 2 2 1 XPA protein N-terminal MAS20 PF02064.15 EXF80918.1 - 0.13 12.3 1.9 0.26 11.4 1.9 1.5 1 0 0 1 1 1 0 MAS20 protein import receptor Endonuc_Holl PF10107.9 EXF80918.1 - 0.13 12.1 1.4 0.23 11.3 1.4 1.3 1 0 0 1 1 1 0 Endonuclease related to archaeal Holliday junction resolvase ArfGap PF01412.18 EXF80918.1 - 0.91 9.6 3.2 0.46 10.6 0.4 1.9 2 0 0 2 2 2 0 Putative GTPase activating protein for Arf Striatin PF08232.12 EXF80919.1 - 1.8e-42 145.6 3.0 1.8e-42 145.6 3.0 2.6 2 1 0 2 2 2 1 Striatin family WD40 PF00400.32 EXF80919.1 - 9.8e-28 95.9 20.0 1.2e-05 25.9 0.1 8.0 7 1 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EXF80919.1 - 3.5e-06 27.2 0.0 5.1 7.5 0.0 5.0 3 1 2 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain TFIIA PF03153.13 EXF80919.1 - 0.00043 20.4 13.0 0.00043 20.4 13.0 2.1 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit ADH_N_2 PF16884.5 EXF80919.1 - 0.072 13.0 0.3 0.19 11.7 0.0 1.8 2 0 0 2 2 2 0 N-terminal domain of oxidoreductase MNSV_P7B PF06692.11 EXF80919.1 - 0.088 12.8 0.0 0.46 10.5 0.0 2.2 1 0 0 1 1 1 0 Melon necrotic spot virus P7B protein Ge1_WD40 PF16529.5 EXF80919.1 - 0.13 11.1 0.0 0.85 8.5 0.0 2.3 2 1 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 EXF80919.1 - 0.13 10.7 0.0 0.31 9.5 0.0 1.5 2 0 0 2 2 2 0 Cytochrome D1 heme domain Spt20 PF12090.8 EXF80919.1 - 0.82 9.2 15.1 1.5 8.4 15.1 1.3 1 0 0 1 1 1 0 Spt20 family Phostensin PF13914.6 EXF80919.1 - 2.4 8.8 8.8 7.7 7.2 8.8 1.8 1 0 0 1 1 1 0 Phostensin PP1-binding and SH3-binding region RskA PF10099.9 EXF80920.1 - 0.011 16.1 2.1 0.011 16.1 2.1 5.2 5 2 0 5 5 5 0 Anti-sigma-K factor rskA BC10 PF06726.12 EXF80921.1 - 8.3e-18 64.4 11.4 1.5e-17 63.6 11.4 1.4 1 0 0 1 1 1 1 Bladder cancer-related protein BC10 LicD PF04991.13 EXF80924.1 - 5.3e-24 85.6 7.6 1.2e-16 61.6 3.5 2.1 1 1 1 2 2 2 2 LicD family WLM PF08325.10 EXF80925.1 - 2.1e-50 171.4 0.1 2.1e-50 171.4 0.1 1.4 2 0 0 2 2 2 1 WLM domain DUF45 PF01863.17 EXF80925.1 - 0.00013 22.1 0.8 0.00027 21.1 0.8 1.5 1 0 0 1 1 1 1 Protein of unknown function DUF45 Reprolysin_5 PF13688.6 EXF80925.1 - 0.03 14.5 0.8 0.073 13.2 0.8 1.8 1 1 0 1 1 1 0 Metallo-peptidase family M12 ubiquitin PF00240.23 EXF80925.1 - 0.043 13.6 0.0 0.081 12.7 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin family SprT-like PF10263.9 EXF80925.1 - 0.047 13.5 0.1 0.086 12.7 0.1 1.6 1 0 0 1 1 1 0 SprT-like family ER_lumen_recept PF00810.18 EXF80926.1 - 4.6e-54 183.3 9.2 4.6e-54 183.3 9.2 1.4 2 0 0 2 2 2 1 ER lumen protein retaining receptor PQ-loop PF04193.14 EXF80926.1 - 1.3 8.9 14.1 0.38 10.6 1.0 3.2 4 0 0 4 4 4 0 PQ loop repeat DUF2207 PF09972.9 EXF80927.1 - 0.026 13.3 0.0 0.045 12.5 0.0 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) ISG65-75 PF11727.8 EXF80927.1 - 0.12 11.6 22.2 0.034 13.4 4.6 2.3 1 1 1 2 2 2 0 Invariant surface glycoprotein Macoilin PF09726.9 EXF80927.1 - 0.35 9.4 10.8 0.47 8.9 10.8 1.1 1 0 0 1 1 1 0 Macoilin family RNase_H2_suC PF08615.11 EXF80927.1 - 0.43 10.8 4.4 0.45 10.7 2.7 2.1 2 1 0 2 2 2 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) DUF3584 PF12128.8 EXF80927.1 - 1.1 6.7 27.5 1.5 6.2 27.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) FAM196 PF15265.6 EXF80927.1 - 1.3 8.5 17.0 2.1 7.8 17.0 1.3 1 0 0 1 1 1 0 FAM196 family RIFIN PF02009.16 EXF80927.1 - 1.7 8.5 20.6 4.4 7.1 20.6 1.5 1 1 0 1 1 1 0 Rifin DUF2232 PF09991.9 EXF80927.1 - 2.6 7.2 5.5 8.2 5.5 0.1 2.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2232) LapA_dom PF06305.11 EXF80927.1 - 5.3 6.9 5.5 0.94 9.3 0.1 2.5 3 0 0 3 3 3 0 Lipopolysaccharide assembly protein A domain DUF966 PF06136.13 EXF80927.1 - 6.3 6.4 11.4 9.8 5.8 11.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF966) MSC PF09402.10 EXF80927.1 - 7.1 6.0 6.9 11 5.4 6.9 1.2 1 0 0 1 1 1 0 Man1-Src1p-C-terminal domain Ank_4 PF13637.6 EXF80929.1 - 3.4e-12 46.6 2.2 9.1e-07 29.3 0.0 4.5 4 1 1 5 5 5 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EXF80929.1 - 2.2e-11 44.2 3.2 3.4e-06 27.5 0.5 3.6 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.30 EXF80929.1 - 2.1e-10 40.6 1.8 0.0049 17.3 0.0 4.6 5 0 0 5 5 5 2 Ankyrin repeat Ank_5 PF13857.6 EXF80929.1 - 2.4e-10 40.5 2.3 1.4e-06 28.5 0.2 3.9 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EXF80929.1 - 1.1e-06 28.5 1.7 0.096 13.3 0.0 5.0 4 1 0 4 4 4 2 Ankyrin repeat Pec_lyase_C PF00544.19 EXF80930.1 - 3.5e-15 56.2 9.3 2.7e-13 50.0 9.3 2.3 1 1 0 1 1 1 1 Pectate lyase MFS_1 PF07690.16 EXF80931.1 - 1.9e-38 132.3 17.8 1.9e-38 132.3 17.8 1.9 2 0 0 2 2 2 1 Major Facilitator Superfamily DUF2070 PF09843.9 EXF80931.1 - 0.00098 17.5 2.2 0.00098 17.5 2.2 1.7 2 0 0 2 2 2 1 Predicted membrane protein (DUF2070) Lyase_1 PF00206.20 EXF80932.1 - 7.6e-47 160.2 0.0 1.4e-46 159.3 0.0 1.3 1 0 0 1 1 1 1 Lyase ADSL_C PF10397.9 EXF80932.1 - 1.7e-18 66.9 1.0 4.3e-18 65.6 0.2 2.2 3 0 0 3 3 3 1 Adenylosuccinate lyase C-terminus Fungal_trans_2 PF11951.8 EXF80933.1 - 1.7e-11 43.6 0.8 7.4e-11 41.5 0.1 1.9 2 0 0 2 2 2 1 Fungal specific transcription factor domain Fungal_trans PF04082.18 EXF80934.1 - 1.4e-26 93.1 0.0 2.3e-26 92.4 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF80934.1 - 0.012 15.7 2.7 0.022 14.9 2.7 1.4 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Aldo_ket_red PF00248.21 EXF80935.1 - 3e-49 167.8 0.0 6e-47 160.2 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family Death PF00531.22 EXF80935.1 - 0.0069 16.5 0.0 1.2 9.4 0.0 3.1 2 1 1 3 3 3 1 Death domain MFS_1 PF07690.16 EXF80936.1 - 4.4e-19 68.6 26.9 4.4e-19 68.6 26.9 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF80936.1 - 7.5e-06 25.1 8.2 7.5e-06 25.1 8.2 2.7 1 1 1 3 3 3 1 Sugar (and other) transporter S_4TM PF18159.1 EXF80936.1 - 1 8.6 4.2 0.23 10.7 0.3 1.9 2 0 0 2 2 2 0 SMODS-associating 4TM effector domain PHO4 PF01384.20 EXF80938.1 - 5.7e-88 295.2 14.8 6.5e-88 295.0 14.8 1.0 1 0 0 1 1 1 1 Phosphate transporter family UPF0444 PF15475.6 EXF80938.1 - 3.4 8.0 10.0 1.1 9.6 0.7 2.8 2 0 0 2 2 2 0 Transmembrane protein C12orf23, UPF0444 Tmemb_40 PF10160.9 EXF80938.1 - 5.1 6.5 7.4 1.9 7.9 4.1 1.9 1 1 1 2 2 2 0 Predicted membrane protein Tannase PF07519.11 EXF80939.1 - 4.8e-88 296.1 0.5 5.5e-88 295.9 0.5 1.0 1 0 0 1 1 1 1 Tannase and feruloyl esterase Peptidase_S9 PF00326.21 EXF80939.1 - 1.5e-07 31.2 0.0 0.0017 17.8 0.0 2.1 2 0 0 2 2 2 2 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 EXF80939.1 - 0.009 15.3 0.0 0.027 13.7 0.0 1.7 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EXF80939.1 - 0.01 15.5 2.0 0.012 15.3 0.0 2.0 2 1 0 2 2 2 0 alpha/beta hydrolase fold Gcd10p PF04189.13 EXF80940.1 - 2.4e-124 414.3 0.0 3e-124 414.0 0.0 1.1 1 0 0 1 1 1 1 Gcd10p family FeoB_Cyto PF17910.1 EXF80940.1 - 0.018 15.6 0.0 0.11 13.1 0.0 2.3 1 1 0 1 1 1 0 FeoB cytosolic helical domain Mucin PF01456.17 EXF80940.1 - 2.5 8.1 12.7 4.7 7.2 12.7 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein P21-Arc PF04062.14 EXF80941.1 - 8.5e-72 240.8 0.0 9.7e-72 240.6 0.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex ARPC3 (21 kDa) subunit COesterase PF00135.28 EXF80943.1 - 4.5e-78 263.4 0.0 6.6e-78 262.8 0.0 1.2 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EXF80943.1 - 1.3e-05 25.2 0.5 0.00014 21.8 0.4 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EXF80943.1 - 0.04 13.4 0.4 0.069 12.6 0.4 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family Fungal_trans_2 PF11951.8 EXF80944.1 - 1.1e-09 37.6 0.0 1.1e-07 31.0 0.0 2.3 2 0 0 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF80944.1 - 8.2e-06 25.9 11.5 1.4e-05 25.1 11.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CFEM PF05730.11 EXF80945.1 - 0.12 12.4 13.6 0.25 11.5 13.5 1.8 1 1 0 1 1 1 0 CFEM domain Macoilin PF09726.9 EXF80945.1 - 0.97 7.9 4.1 0.98 7.9 4.1 1.1 1 0 0 1 1 1 0 Macoilin family FSA_C PF10479.9 EXF80945.1 - 7.3 4.6 11.1 7.5 4.6 11.1 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus FliD_N PF02465.18 EXF80945.1 - 9.4 7.0 16.3 60 4.4 16.3 2.1 1 1 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus Trp_oprn_chp PF09534.10 EXF80945.1 - 9.8 5.9 21.0 0.86 9.4 14.5 2.0 2 0 0 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Ion_trans PF00520.31 EXF80946.1 - 2.1e-08 33.7 2.6 2.8e-08 33.3 2.6 1.1 1 0 0 1 1 1 1 Ion transport protein RRM_1 PF00076.22 EXF80947.1 - 1.4e-16 60.1 0.0 2.1e-16 59.5 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Spc7 PF08317.11 EXF80947.1 - 0.026 13.4 2.4 0.032 13.1 2.4 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Nup35_RRM_2 PF14605.6 EXF80947.1 - 0.034 14.1 0.0 0.066 13.2 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif BLOC1_2 PF10046.9 EXF80947.1 - 0.038 14.3 0.3 0.06 13.7 0.3 1.3 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF724 PF05266.14 EXF80947.1 - 0.066 13.0 3.5 0.089 12.6 3.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF724) GPS2_interact PF15784.5 EXF80947.1 - 0.091 13.2 1.7 0.15 12.5 1.7 1.4 1 0 0 1 1 1 0 G-protein pathway suppressor 2-interacting domain RRM_occluded PF16842.5 EXF80947.1 - 0.15 11.9 0.0 0.31 10.9 0.0 1.6 1 1 0 1 1 1 0 Occluded RNA-recognition motif V_ATPase_I PF01496.19 EXF80947.1 - 0.19 9.6 1.0 0.22 9.4 1.0 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family EMP24_GP25L PF01105.24 EXF80947.1 - 0.23 11.4 1.8 0.33 10.9 1.8 1.1 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD UPF0242 PF06785.11 EXF80947.1 - 0.37 10.9 2.4 0.48 10.5 2.4 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus APG6_N PF17675.1 EXF80947.1 - 0.69 10.4 6.9 0.97 10.0 6.9 1.1 1 0 0 1 1 1 0 Apg6 coiled-coil region DivIC PF04977.15 EXF80947.1 - 1.5 8.6 4.7 2.4 8.0 4.7 1.2 1 0 0 1 1 1 0 Septum formation initiator HECT PF00632.25 EXF80948.1 - 1.3e-94 317.1 0.0 1.8e-94 316.7 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.26 EXF80948.1 - 1.4e-34 117.8 24.7 6.9e-13 48.4 6.3 3.9 4 0 0 4 4 4 3 WW domain C2 PF00168.30 EXF80948.1 - 7.7e-19 67.9 0.1 2.3e-18 66.3 0.1 1.9 1 0 0 1 1 1 1 C2 domain Oxidored_q6 PF01058.22 EXF80949.1 - 1.4e-22 79.9 0.1 2.2e-22 79.3 0.1 1.3 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase, 20 Kd subunit p450 PF00067.22 EXF80951.1 - 5.8e-50 170.4 0.0 1.2e-49 169.3 0.0 1.5 1 1 0 1 1 1 1 Cytochrome P450 RVT_connect PF06815.13 EXF80951.1 - 0.17 12.2 3.2 0.3 11.4 2.2 1.9 2 0 0 2 2 2 0 Reverse transcriptase connection domain Ceramidase_alk PF04734.13 EXF80952.1 - 2.1e-224 745.9 0.0 2.5e-224 745.6 0.0 1.1 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, N-terminal Ceramidse_alk_C PF17048.5 EXF80952.1 - 3.1e-57 193.1 0.1 5.6e-57 192.3 0.1 1.4 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, C-terminal SBP56 PF05694.11 EXF80952.1 - 0.018 13.9 0.0 0.21 10.4 0.0 2.3 2 1 0 2 2 2 0 56kDa selenium binding protein (SBP56) Cupin_1 PF00190.22 EXF80953.1 - 2.1e-39 134.5 0.0 1.9e-20 73.0 0.0 2.2 2 0 0 2 2 2 2 Cupin Cupin_2 PF07883.11 EXF80953.1 - 2.6e-23 81.5 1.0 3.5e-13 49.1 0.0 2.4 2 0 0 2 2 2 2 Cupin domain Cupin_3 PF05899.12 EXF80953.1 - 2.3e-06 27.2 0.1 0.025 14.3 0.0 2.6 2 0 0 2 2 2 2 Protein of unknown function (DUF861) AraC_binding PF02311.19 EXF80953.1 - 0.0016 18.3 0.1 0.17 11.8 0.0 2.6 3 0 0 3 3 3 1 AraC-like ligand binding domain Endosulfine PF04667.17 EXF80954.1 - 3.3e-28 97.7 0.1 5e-28 97.0 0.1 1.3 1 0 0 1 1 1 1 cAMP-regulated phosphoprotein/endosulfine conserved region UPF0160 PF03690.13 EXF80955.1 - 3.6e-131 437.5 0.0 4e-131 437.4 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0160) Ino80_Iec3 PF14612.6 EXF80956.1 - 2.5e-52 178.9 10.8 5.6e-28 99.2 1.4 2.6 2 1 1 3 3 3 2 IEC3 subunit of the Ino80 complex, chromatin re-modelling Iso_dh PF00180.20 EXF80957.1 - 5.7e-73 246.1 0.0 6.8e-73 245.8 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase RNase_PH PF01138.21 EXF80959.1 - 2.6e-13 50.6 0.0 4.7e-13 49.8 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 EXF80959.1 - 0.016 15.2 0.0 0.039 14.0 0.0 1.6 1 0 0 1 1 1 0 3' exoribonuclease family, domain 2 Cytochrom_C PF00034.21 EXF80961.1 - 5.3e-12 46.7 0.1 7.2e-12 46.3 0.1 1.2 1 0 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.6 EXF80961.1 - 3.5e-09 36.8 2.2 1.3e-08 35.0 2.2 1.7 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C550 PF14495.6 EXF80961.1 - 0.012 15.4 1.7 0.062 13.0 1.7 2.2 1 1 0 1 1 1 0 Cytochrome c-550 domain Cytochrome-c551 PF10643.9 EXF80961.1 - 0.19 11.3 0.0 0.21 11.2 0.0 1.2 1 0 0 1 1 1 0 Photosystem P840 reaction-centre cytochrome c-551 AAA PF00004.29 EXF80962.1 - 1.3e-64 216.5 0.0 2.8e-45 154.0 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EXF80962.1 - 4.9e-12 45.5 1.2 5.9e-05 22.8 0.1 2.7 2 0 0 2 2 2 2 AAA+ lid domain AAA_16 PF13191.6 EXF80962.1 - 6.1e-10 39.7 1.5 0.00047 20.6 0.0 4.8 3 2 1 4 4 4 2 AAA ATPase domain AAA_5 PF07728.14 EXF80962.1 - 5.1e-08 33.0 0.0 0.0034 17.4 0.0 3.0 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EXF80962.1 - 2.3e-07 31.2 0.1 0.018 15.3 0.0 5.1 3 2 2 5 5 4 1 AAA domain AAA_18 PF13238.6 EXF80962.1 - 4.2e-07 30.6 0.0 0.013 16.1 0.0 3.1 2 1 0 2 2 2 2 AAA domain RuvB_N PF05496.12 EXF80962.1 - 2.3e-06 27.4 0.0 0.00037 20.3 0.0 2.4 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 EXF80962.1 - 2.1e-05 24.7 0.0 0.0046 17.1 0.0 2.8 2 1 0 2 2 2 1 AAA domain Rad17 PF03215.15 EXF80962.1 - 5.5e-05 23.2 0.0 0.085 12.8 0.0 2.6 2 1 0 2 2 2 2 Rad17 P-loop domain Zeta_toxin PF06414.12 EXF80962.1 - 7.9e-05 22.0 0.0 0.038 13.3 0.0 3.0 3 0 0 3 3 3 1 Zeta toxin AAA_17 PF13207.6 EXF80962.1 - 0.00016 22.1 0.0 0.92 9.9 0.0 3.2 3 0 0 3 3 2 2 AAA domain IstB_IS21 PF01695.17 EXF80962.1 - 0.00017 21.4 0.0 0.031 14.0 0.0 2.3 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_2 PF07724.14 EXF80962.1 - 0.00017 21.7 0.0 0.0018 18.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_28 PF13521.6 EXF80962.1 - 0.00032 21.0 2.8 0.65 10.2 0.0 3.3 4 1 0 4 4 2 2 AAA domain RNA_helicase PF00910.22 EXF80962.1 - 0.00042 20.7 0.0 0.054 13.9 0.0 2.7 2 0 0 2 2 2 1 RNA helicase Mg_chelatase PF01078.21 EXF80962.1 - 0.00059 19.3 0.1 0.11 11.9 0.0 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI Sigma54_activ_2 PF14532.6 EXF80962.1 - 0.00068 19.8 0.0 0.13 12.3 0.0 2.7 3 0 0 3 3 2 1 Sigma-54 interaction domain AAA_7 PF12775.7 EXF80962.1 - 0.00088 18.8 0.0 0.76 9.3 0.0 2.4 2 0 0 2 2 2 2 P-loop containing dynein motor region Sigma54_activat PF00158.26 EXF80962.1 - 0.0012 18.6 0.0 0.71 9.6 0.0 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain DUF815 PF05673.13 EXF80962.1 - 0.0013 18.0 0.0 0.69 9.0 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF815) AAA_11 PF13086.6 EXF80962.1 - 0.003 17.4 3.4 1.5 8.5 0.0 3.4 3 0 0 3 3 3 1 AAA domain AAA_14 PF13173.6 EXF80962.1 - 0.0031 17.6 0.0 0.06 13.4 0.0 2.4 2 0 0 2 2 2 1 AAA domain TIP49 PF06068.13 EXF80962.1 - 0.0062 15.8 0.0 0.28 10.3 0.0 2.3 2 0 0 2 2 2 1 TIP49 P-loop domain AAA_25 PF13481.6 EXF80962.1 - 0.0091 15.6 0.2 5.5 6.5 0.0 3.9 3 1 1 4 4 4 0 AAA domain AAA_24 PF13479.6 EXF80962.1 - 0.024 14.4 0.0 3.5 7.3 0.0 2.6 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 EXF80962.1 - 0.028 14.9 0.0 2.7 8.5 0.0 2.8 2 0 0 2 2 2 0 ABC transporter TniB PF05621.11 EXF80962.1 - 0.032 13.6 0.0 0.78 9.1 0.0 2.9 4 0 0 4 4 4 0 Bacterial TniB protein NACHT PF05729.12 EXF80962.1 - 0.04 13.8 0.1 5.3 6.9 0.0 3.0 4 0 0 4 4 3 0 NACHT domain TsaE PF02367.17 EXF80962.1 - 0.06 13.3 0.0 1.8 8.6 0.0 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_3 PF07726.11 EXF80962.1 - 0.066 13.1 0.0 2.5 8.0 0.0 2.3 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Viral_helicase1 PF01443.18 EXF80962.1 - 0.085 12.6 0.0 1.4 8.6 0.0 2.3 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase SKI PF01202.22 EXF80962.1 - 0.092 12.9 0.1 11 6.2 0.0 3.2 3 0 0 3 3 3 0 Shikimate kinase AAA_19 PF13245.6 EXF80962.1 - 0.12 12.7 1.8 9.4 6.6 0.0 3.0 3 0 0 3 3 3 0 AAA domain NB-ARC PF00931.22 EXF80962.1 - 0.13 11.4 0.0 1.1 8.4 0.0 2.4 3 0 0 3 3 3 0 NB-ARC domain CRM1_C PF08767.11 EXF80963.1 - 9.2e-135 448.9 4.1 9.2e-135 448.9 4.1 2.9 2 1 0 2 2 2 1 CRM1 C terminal Xpo1 PF08389.12 EXF80963.1 - 8.1e-41 139.5 6.3 8.1e-41 139.5 6.3 4.2 3 1 1 4 4 4 1 Exportin 1-like protein CRM1_repeat_2 PF18784.1 EXF80963.1 - 1.1e-33 114.7 4.0 3.4e-33 113.1 4.0 2.0 1 0 0 1 1 1 1 CRM1 / Exportin repeat 2 CRM1_repeat_3 PF18787.1 EXF80963.1 - 9.9e-28 96.0 1.2 9.9e-28 96.0 1.2 3.3 4 0 0 4 4 4 1 CRM1 / Exportin repeat 3 CRM1_repeat PF18777.1 EXF80963.1 - 5.7e-18 64.1 1.1 1.6e-17 62.7 1.1 1.8 1 0 0 1 1 1 1 Chromosome region maintenance or exportin repeat IBN_N PF03810.19 EXF80963.1 - 7.7e-13 48.2 0.1 2.6e-12 46.5 0.1 2.0 1 0 0 1 1 1 1 Importin-beta N-terminal domain Vac14_Fab1_bd PF12755.7 EXF80963.1 - 0.069 13.7 5.2 3.6 8.3 0.0 5.3 6 0 0 6 6 5 0 Vacuolar 14 Fab1-binding region HD_assoc PF13286.6 EXF80963.1 - 0.076 13.6 0.7 31 5.2 0.2 3.9 4 0 0 4 4 3 0 Phosphohydrolase-associated domain MMS19_C PF12460.8 EXF80963.1 - 0.08 12.0 13.5 0.0073 15.5 1.6 4.0 3 2 1 4 4 4 0 RNAPII transcription regulator C-terminal DUF3385 PF11865.8 EXF80963.1 - 0.24 11.3 9.7 0.33 10.9 0.0 4.4 5 1 0 5 5 5 0 Domain of unknown function (DUF3385) FliH PF02108.16 EXF80963.1 - 0.89 9.6 3.7 1.9 8.5 0.0 3.0 3 0 0 3 3 3 0 Flagellar assembly protein FliH Aminotran_5 PF00266.19 EXF80964.1 - 1.5e-26 93.2 0.0 2.1e-26 92.8 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V B12-binding PF02310.19 EXF80964.1 - 0.0016 18.5 0.1 0.055 13.5 0.0 2.6 2 1 1 3 3 3 1 B12 binding domain RusA PF05866.11 EXF80964.1 - 0.12 12.9 0.0 0.3 11.7 0.0 1.6 1 0 0 1 1 1 0 Endodeoxyribonuclease RusA Metallophos_2 PF12850.7 EXF80965.1 - 1.1e-11 45.2 0.0 1.5e-11 44.7 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Shugoshin_C PF07557.11 EXF80966.1 - 2.4e-12 46.4 7.3 2e-11 43.5 7.3 2.8 1 0 0 1 1 1 1 Shugoshin C terminus Shugoshin_N PF07558.11 EXF80966.1 - 0.00013 21.7 2.7 0.00034 20.4 2.7 1.8 1 0 0 1 1 1 1 Shugoshin N-terminal coiled-coil region Mod_r PF07200.13 EXF80966.1 - 3.9 7.6 7.9 0.18 11.9 0.6 2.3 2 1 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein DASH_Dad2 PF08654.10 EXF80967.1 - 3.6e-32 110.7 0.7 3.6e-32 110.7 0.7 1.4 2 0 0 2 2 2 1 DASH complex subunit Dad2 Rogdi_lz PF10259.9 EXF80967.1 - 0.0051 16.3 0.5 0.0055 16.2 0.5 1.1 1 0 0 1 1 1 1 Rogdi leucine zipper containing protein Seryl_tRNA_N PF02403.22 EXF80967.1 - 0.019 15.2 0.2 0.039 14.2 0.2 1.5 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain DASH_Duo1 PF08651.10 EXF80967.1 - 0.087 12.6 0.2 0.15 11.9 0.2 1.3 1 0 0 1 1 1 0 DASH complex subunit Duo1 COesterase PF00135.28 EXF80969.1 - 3.8e-72 243.8 0.0 5.1e-72 243.4 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EXF80969.1 - 1.3e-05 25.2 1.5 3.8e-05 23.6 0.3 2.2 2 1 0 2 2 2 1 alpha/beta hydrolase fold SKG6 PF08693.10 EXF80970.1 - 5e-13 48.2 1.8 1.1e-12 47.2 1.8 1.6 1 0 0 1 1 1 1 Transmembrane alpha-helix domain CD34_antigen PF06365.12 EXF80970.1 - 0.022 14.3 0.1 0.063 12.9 0.0 1.7 2 0 0 2 2 2 0 CD34/Podocalyxin family TFIIA PF03153.13 EXF80970.1 - 0.023 14.7 11.2 0.037 14.0 11.2 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CcmD PF04995.14 EXF80970.1 - 0.038 14.1 0.3 0.065 13.3 0.3 1.3 1 0 0 1 1 1 0 Heme exporter protein D (CcmD) DUF4131 PF13567.6 EXF80970.1 - 0.17 11.6 1.3 8.6 6.0 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) Endomucin PF07010.12 EXF80970.1 - 0.4 10.6 28.5 0.75 9.7 28.5 1.5 1 0 0 1 1 1 0 Endomucin Suf PF05843.14 EXF80970.1 - 1.7 8.5 8.3 2.7 7.9 8.3 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Ndc1_Nup PF09531.10 EXF80970.1 - 3.2 6.3 9.0 4.1 6.0 9.0 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup HA2 PF04408.23 EXF80972.1 - 8.7e-18 64.6 1.1 2.7e-17 63.0 0.1 2.3 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EXF80972.1 - 1.1e-14 54.5 0.0 2.7e-14 53.3 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EXF80972.1 - 1.1e-13 51.4 0.2 3.7e-13 49.8 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 EXF80972.1 - 2.7e-05 24.5 0.1 8.7e-05 22.8 0.1 1.9 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EXF80972.1 - 6.2e-05 22.8 0.1 0.00016 21.4 0.1 1.7 1 0 0 1 1 1 1 AAA domain AAA_23 PF13476.6 EXF80972.1 - 0.00011 22.7 2.2 0.0078 16.7 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 EXF80972.1 - 0.0011 19.4 0.2 0.0026 18.1 0.2 1.6 1 0 0 1 1 1 1 AAA domain DEAD PF00270.29 EXF80972.1 - 0.0019 18.0 1.0 0.0019 18.0 1.0 2.1 2 1 0 2 2 2 1 DEAD/DEAH box helicase T2SSE PF00437.20 EXF80972.1 - 0.019 14.1 0.0 0.041 12.9 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein GDI PF00996.18 EXF80972.1 - 0.034 12.7 0.1 0.075 11.5 0.1 1.5 2 0 0 2 2 2 0 GDP dissociation inhibitor AAA_7 PF12775.7 EXF80972.1 - 0.055 13.0 0.1 0.25 10.8 0.0 2.1 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_14 PF13173.6 EXF80972.1 - 0.067 13.2 0.4 5.7 7.0 0.0 2.5 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 EXF80972.1 - 0.072 12.4 0.3 0.24 10.7 0.1 1.8 1 1 0 1 1 1 0 Zeta toxin PhoH PF02562.16 EXF80972.1 - 0.082 12.4 0.1 0.64 9.4 0.0 2.3 2 0 0 2 2 2 0 PhoH-like protein cobW PF02492.19 EXF80972.1 - 0.11 12.0 0.2 1.7 8.2 0.1 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_29 PF13555.6 EXF80972.1 - 0.14 11.9 0.0 0.42 10.4 0.0 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain SRP54 PF00448.22 EXF80972.1 - 4.8 6.8 6.1 1.6 8.3 0.1 2.8 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain CUE PF02845.16 EXF80973.1 - 1.6e-12 46.8 0.0 2.8e-12 46.1 0.0 1.4 1 0 0 1 1 1 1 CUE domain Ank_2 PF12796.7 EXF80974.1 - 7.2e-29 100.2 1.4 1.1e-08 35.5 0.0 4.8 2 1 1 4 4 4 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EXF80974.1 - 2e-27 95.2 3.8 4.2e-07 30.4 0.0 6.8 4 2 4 8 8 8 5 Ankyrin repeats (many copies) SPX PF03105.19 EXF80974.1 - 2.9e-19 70.3 17.0 1.7e-09 38.1 1.3 3.2 1 1 2 3 3 3 3 SPX domain Ank_3 PF13606.6 EXF80974.1 - 3.4e-17 60.8 7.2 0.006 17.0 0.0 7.7 9 0 0 9 9 9 4 Ankyrin repeat Ank_5 PF13857.6 EXF80974.1 - 6e-17 61.5 7.1 0.00097 19.4 0.0 6.5 2 2 5 7 7 7 7 Ankyrin repeats (many copies) Ank PF00023.30 EXF80974.1 - 7.7e-11 41.9 10.4 0.016 15.7 0.0 7.3 8 0 0 8 8 8 3 Ankyrin repeat GDPD PF03009.17 EXF80974.1 - 5.7e-08 32.8 0.0 2.8e-07 30.5 0.0 2.1 2 0 0 2 2 2 1 Glycerophosphoryl diester phosphodiesterase family RVP PF00077.20 EXF80974.1 - 0.042 14.2 0.0 0.1 12.9 0.0 1.6 1 0 0 1 1 1 0 Retroviral aspartyl protease Coa1 PF08695.10 EXF80976.1 - 2.1e-41 140.3 0.0 2.9e-41 139.9 0.0 1.2 1 0 0 1 1 1 1 Cytochrome oxidase complex assembly protein 1 Ribosomal_L3 PF00297.22 EXF80977.1 - 8.2e-17 61.2 3.1 3.4e-12 46.1 0.9 2.1 1 1 1 2 2 2 2 Ribosomal protein L3 Complex1_LYR PF05347.15 EXF80978.1 - 0.004 17.2 1.8 0.0053 16.8 0.9 1.7 2 0 0 2 2 2 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 EXF80978.1 - 0.0093 16.7 1.3 0.013 16.3 1.3 1.5 1 1 0 1 1 1 1 Complex1_LYR-like Complex1_LYR_1 PF13232.6 EXF80978.1 - 0.031 14.9 0.8 0.06 13.9 0.7 1.7 1 1 0 1 1 1 0 Complex1_LYR-like Mito_carr PF00153.27 EXF80979.1 - 1.3e-41 140.4 6.9 2.7e-15 56.0 0.1 4.1 3 1 0 3 3 3 3 Mitochondrial carrier protein Cation_efflux PF01545.21 EXF80979.1 - 0.015 15.0 0.0 2.6 7.7 0.0 2.5 3 0 0 3 3 3 0 Cation efflux family DUF2293 PF10056.9 EXF80980.1 - 3.1e-33 113.9 0.3 3.1e-33 113.9 0.3 2.0 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2293) Snf7 PF03357.21 EXF80981.1 - 1.4e-36 125.7 8.2 1.7e-36 125.4 8.2 1.0 1 0 0 1 1 1 1 Snf7 ATE_C PF04377.15 EXF80982.1 - 5e-48 163.1 0.2 9.6e-48 162.2 0.2 1.5 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, C terminus ATE_N PF04376.13 EXF80982.1 - 1.7e-18 66.8 0.1 3.6e-18 65.7 0.1 1.6 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, N terminus Acetyltransf_6 PF13480.7 EXF80982.1 - 0.12 12.5 1.5 0.61 10.2 0.1 2.7 3 0 0 3 3 3 0 Acetyltransferase (GNAT) domain NUDIX PF00293.28 EXF80983.1 - 4.4e-18 65.6 1.5 5.4e-18 65.3 1.5 1.1 1 0 0 1 1 1 1 NUDIX domain NUDIX_2 PF13869.6 EXF80983.1 - 0.032 13.8 0.0 0.041 13.5 0.0 1.2 1 0 0 1 1 1 0 Nucleotide hydrolase LSM PF01423.22 EXF80984.1 - 4.7e-15 55.0 0.0 7.6e-15 54.4 0.0 1.4 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 EXF80984.1 - 0.2 11.3 0.0 0.35 10.5 0.0 1.4 1 0 0 1 1 1 0 Hfq protein Glyco_hyd_65N_2 PF14498.6 EXF80985.1 - 0.021 14.7 0.0 0.038 13.8 0.0 1.4 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain Glyco_hydro_65N PF03636.15 EXF80985.1 - 0.11 12.1 0.2 0.19 11.3 0.2 1.5 1 1 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain BRK PF07533.16 EXF80985.1 - 0.45 10.2 2.5 4 7.2 0.1 3.0 3 0 0 3 3 3 0 BRK domain Mob1_phocein PF03637.17 EXF80986.1 - 1.8e-70 236.4 0.0 2.1e-70 236.1 0.0 1.1 1 0 0 1 1 1 1 Mob1/phocein family Mrx7 PF10906.8 EXF80986.1 - 0.31 11.3 1.3 0.48 10.7 0.2 1.9 3 0 0 3 3 3 0 MIOREX complex component 7 OSCP PF00213.18 EXF80987.1 - 2.7e-49 167.6 0.7 3.7e-49 167.1 0.7 1.2 1 0 0 1 1 1 1 ATP synthase delta (OSCP) subunit Acyl-CoA_dh_1 PF00441.24 EXF80987.1 - 0.13 12.5 1.6 2.2 8.4 0.1 2.1 2 0 0 2 2 2 0 Acyl-CoA dehydrogenase, C-terminal domain Glyco_hydro_63 PF03200.16 EXF80988.1 - 7.8e-07 28.2 10.6 5.3e-06 25.5 0.1 4.3 5 1 0 5 5 5 2 Glycosyl hydrolase family 63 C-terminal domain TTSSLRR PF12468.8 EXF80988.1 - 0.11 12.8 0.1 0.34 11.2 0.1 1.8 1 0 0 1 1 1 0 Type III secretion system leucine rich repeat protein RasGEF PF00617.19 EXF80989.1 - 1.9e-48 165.0 0.1 3.5e-48 164.1 0.1 1.5 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 EXF80989.1 - 3.1e-11 43.4 0.1 8.7e-11 42.0 0.0 1.7 2 0 0 2 2 1 1 RasGEF N-terminal motif Ras PF00071.22 EXF80989.1 - 2.3e-07 30.5 1.6 4.7e-05 23.1 0.0 2.8 3 0 0 3 3 3 1 Ras family RsgA_GTPase PF03193.16 EXF80989.1 - 2.4e-05 24.3 0.1 0.27 11.1 0.1 2.4 2 0 0 2 2 2 2 RsgA GTPase PAXIP1_C PF15364.6 EXF80989.1 - 0.0021 18.4 2.6 0.0021 18.4 2.6 2.2 2 0 0 2 2 2 1 PAXIP1-associated-protein-1 C term PTIP binding protein Roc PF08477.13 EXF80989.1 - 0.0063 16.7 0.0 0.87 9.8 0.0 2.4 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 EXF80989.1 - 0.0064 16.1 0.0 0.16 11.5 0.0 2.6 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EXF80989.1 - 0.043 13.9 0.2 0.17 12.0 0.2 2.1 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_16 PF13191.6 EXF80989.1 - 0.048 14.0 0.0 0.16 12.4 0.0 1.9 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 EXF80989.1 - 0.068 13.4 0.1 1.9 8.8 0.0 2.7 3 0 0 3 3 2 0 AAA domain FtsK_SpoIIIE PF01580.18 EXF80989.1 - 0.12 11.7 0.0 0.34 10.2 0.0 1.7 1 0 0 1 1 1 0 FtsK/SpoIIIE family IIGP PF05049.13 EXF80989.1 - 0.12 11.4 0.1 0.12 11.4 0.1 1.7 2 0 0 2 2 2 0 Interferon-inducible GTPase (IIGP) ATP_bind_1 PF03029.17 EXF80989.1 - 0.13 12.1 0.2 12 5.6 0.1 2.4 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein ABC_tran PF00005.27 EXF80989.1 - 0.17 12.4 0.0 0.54 10.8 0.0 1.9 1 0 0 1 1 1 0 ABC transporter zf-HIT PF04438.16 EXF80992.1 - 7e-09 35.4 10.2 9.7e-09 35.0 10.2 1.2 1 0 0 1 1 1 1 HIT zinc finger zf-MYND PF01753.18 EXF80992.1 - 0.0093 16.0 7.8 0.015 15.4 7.8 1.3 1 0 0 1 1 1 1 MYND finger zf-B_box PF00643.24 EXF80992.1 - 0.15 12.2 8.4 0.21 11.7 8.4 1.2 1 0 0 1 1 1 0 B-box zinc finger Nfu_N PF08712.11 EXF80993.1 - 2.8e-29 101.0 0.0 1.2e-28 98.9 0.0 2.0 2 0 0 2 2 2 1 Scaffold protein Nfu/NifU N terminal NifU PF01106.17 EXF80993.1 - 2e-27 95.1 0.1 3.3e-27 94.4 0.1 1.3 1 0 0 1 1 1 1 NifU-like domain YojJ PF10372.9 EXF80993.1 - 0.26 11.4 0.9 0.59 10.3 0.5 1.8 2 0 0 2 2 2 0 Bacterial membrane-spanning protein N-terminus PSP1 PF04468.12 EXF80994.1 - 8.9e-28 96.4 1.3 8.9e-28 96.4 1.3 2.0 2 0 0 2 2 2 1 PSP1 C-terminal conserved region HOOK PF05622.12 EXF80994.1 - 0.021 13.0 9.7 0.034 12.3 9.7 1.2 1 0 0 1 1 1 0 HOOK protein Suf PF05843.14 EXF80994.1 - 1.3 8.9 15.3 0.79 9.7 5.0 2.8 3 0 0 3 3 3 0 Suppressor of forked protein (Suf) Neur_chan_memb PF02932.16 EXF80994.1 - 2.2 8.3 3.3 7.7 6.5 3.3 1.9 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Hid1 PF12722.7 EXF80994.1 - 3.6 5.6 6.4 7.2 4.6 6.4 1.4 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Ribosomal_L15e PF00827.17 EXF80995.1 - 4.7e-89 297.2 10.5 5.7e-89 296.9 10.5 1.0 1 0 0 1 1 1 1 Ribosomal L15 CFIA_Pcf11 PF11526.8 EXF80997.1 - 3.3e-07 30.7 1.4 1.1e-06 29.0 1.4 1.9 1 1 0 1 1 1 1 Subunit of cleavage factor IA Pcf11 CTD_bind PF04818.13 EXF80997.1 - 5.3e-06 27.2 0.0 3.6e-05 24.5 0.0 2.5 3 0 0 3 3 3 1 RNA polymerase II-binding domain. VHS PF00790.19 EXF80997.1 - 0.00075 19.4 0.0 0.0021 17.9 0.0 1.7 2 0 0 2 2 2 1 VHS domain zf-C2H2_4 PF13894.6 EXF80997.1 - 0.035 14.9 4.0 1.9 9.5 0.4 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2HC_2 PF13913.6 EXF80997.1 - 3.1 7.8 6.4 5.3 7.1 1.0 2.4 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf_UBZ PF18439.1 EXF80997.1 - 3.4 7.3 8.0 1.1 8.9 2.5 2.7 2 1 0 2 2 2 0 Ubiquitin-Binding Zinc Finger Glyco_transf_90 PF05686.12 EXF80998.1 - 5.7e-22 78.2 0.0 3e-17 62.6 0.0 2.1 2 0 0 2 2 2 2 Glycosyl transferase family 90 SR-25 PF10500.9 EXF80998.1 - 1.3 8.6 8.5 2.3 7.8 8.5 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Glyco_hydro_72 PF03198.14 EXF80999.1 - 3.6e-126 420.7 5.1 4.6e-126 420.3 5.1 1.0 1 0 0 1 1 1 1 Glucanosyltransferase Cellulase PF00150.18 EXF80999.1 - 1.5e-05 24.6 1.1 0.00019 21.0 1.1 2.2 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) FCH PF00611.23 EXF81000.1 - 9.1e-26 90.0 1.9 1.4e-25 89.4 0.1 2.3 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_9 PF14604.6 EXF81000.1 - 5e-19 67.9 0.5 4.3e-13 48.9 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain C1_1 PF00130.22 EXF81000.1 - 1.8e-15 56.6 5.3 2.8e-15 55.9 5.3 1.3 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) SH3_1 PF00018.28 EXF81000.1 - 8.8e-13 47.7 0.1 6e-06 25.8 0.0 2.4 2 0 0 2 2 2 2 SH3 domain SH3_10 PF17902.1 EXF81000.1 - 0.00074 19.5 0.0 0.049 13.7 0.0 2.8 2 0 0 2 2 2 1 SH3 domain SH3_3 PF08239.11 EXF81000.1 - 0.0013 18.9 0.3 0.6 10.4 0.1 2.5 2 0 0 2 2 2 2 Bacterial SH3 domain SH3_2 PF07653.17 EXF81000.1 - 0.028 14.1 0.1 1.9 8.2 0.0 2.5 2 0 0 2 2 2 0 Variant SH3 domain C1_2 PF03107.16 EXF81000.1 - 0.046 14.0 5.5 0.081 13.3 5.5 1.4 1 0 0 1 1 1 0 C1 domain Allexi_40kDa PF05549.11 EXF81000.1 - 0.052 13.1 3.7 0.088 12.3 0.1 2.5 2 1 0 2 2 2 0 Allexivirus 40kDa protein SH3_16 PF18348.1 EXF81000.1 - 0.08 12.8 0.0 2.3 8.1 0.0 2.4 2 0 0 2 2 2 0 Bacterial dipeptidyl-peptidase Sh3 domain FYVE PF01363.21 EXF81000.1 - 0.23 11.6 3.4 0.49 10.6 3.4 1.4 1 0 0 1 1 1 0 FYVE zinc finger Dor1 PF04124.12 EXF81000.1 - 0.44 9.2 5.7 0.11 11.2 2.0 1.7 2 0 0 2 2 2 0 Dor1-like family DEAD PF00270.29 EXF81001.1 - 7e-34 117.1 0.0 1.5e-33 116.0 0.0 1.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EXF81001.1 - 2.7e-24 85.7 0.0 5.7e-24 84.6 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_30 PF13604.6 EXF81001.1 - 0.00018 21.3 0.0 0.00033 20.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 EXF81001.1 - 0.00021 21.3 0.0 0.00041 20.4 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 EXF81001.1 - 0.05 13.9 0.0 0.79 10.0 0.0 2.3 2 1 0 2 2 2 0 AAA domain AAA_22 PF13401.6 EXF81001.1 - 0.094 13.0 1.1 0.48 10.7 0.7 2.3 2 1 0 2 2 2 0 AAA domain CFEM PF05730.11 EXF81002.1 - 0.048 13.7 3.7 0.091 12.9 3.7 1.4 1 0 0 1 1 1 0 CFEM domain MFS_1 PF07690.16 EXF81003.1 - 3.5e-06 26.2 15.9 0.0012 17.8 13.3 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily DUF2434 PF10361.9 EXF81003.1 - 0.1 11.6 0.1 0.1 11.6 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2434) Phage_holin_3_6 PF07332.11 EXF81003.1 - 9.3 6.3 18.6 0.065 13.3 2.9 3.5 4 0 0 4 4 4 0 Putative Actinobacterial Holin-X, holin superfamily III ECH_1 PF00378.20 EXF81005.1 - 3.6e-40 137.9 0.0 8.8e-40 136.6 0.0 1.5 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EXF81005.1 - 5e-34 118.3 0.0 3.6e-31 108.9 0.0 2.1 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase Tfb5 PF06331.12 EXF81006.1 - 8.6e-27 92.9 0.7 9.4e-27 92.8 0.7 1.0 1 0 0 1 1 1 1 Transcription factor TFIIH complex subunit Tfb5 RCR PF12273.8 EXF81007.1 - 0.012 16.3 8.5 0.14 12.8 8.5 2.2 1 1 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red CopD PF05425.13 EXF81007.1 - 0.11 12.9 0.1 0.17 12.3 0.1 1.3 1 0 0 1 1 1 0 Copper resistance protein D UPF0254 PF06787.11 EXF81007.1 - 0.26 11.1 0.0 0.34 10.7 0.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0254) Glyco_hydro_61 PF03443.14 EXF81009.1 - 4.5e-66 222.7 0.1 5.4e-66 222.4 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 S4 PF01479.25 EXF81010.1 - 3e-11 42.8 0.0 7.8e-11 41.5 0.0 1.7 2 0 0 2 2 2 1 S4 domain Ribosomal_S4 PF00163.19 EXF81010.1 - 1.2e-09 38.9 0.5 1.9e-09 38.3 0.5 1.4 1 0 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain THDPS_N_2 PF14805.6 EXF81010.1 - 0.046 14.0 0.0 0.089 13.0 0.0 1.6 1 0 0 1 1 1 0 Tetrahydrodipicolinate N-succinyltransferase N-terminal Ribosomal_S18 PF01084.20 EXF81011.1 - 1.1e-11 44.8 0.1 2e-11 43.9 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein S18 PPR_2 PF13041.6 EXF81012.1 - 6.7e-06 26.2 0.0 4.4 7.6 0.0 4.6 4 0 0 4 4 4 2 PPR repeat family PPR PF01535.20 EXF81012.1 - 0.0004 20.4 0.1 1.3 9.4 0.0 4.0 3 0 0 3 3 3 2 PPR repeat PPR_3 PF13812.6 EXF81012.1 - 0.058 13.5 0.1 37 4.5 0.0 3.5 4 0 0 4 4 4 0 Pentatricopeptide repeat domain DUF3850 PF12961.7 EXF81012.1 - 0.064 13.3 0.0 0.17 11.9 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3850) ADH_zinc_N PF00107.26 EXF81013.1 - 1.9e-07 31.1 0.1 3.9e-07 30.1 0.0 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EXF81013.1 - 0.0022 17.8 0.0 0.0037 17.1 0.0 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain zf-C2H2 PF00096.26 EXF81014.1 - 1.8e-07 31.2 13.4 0.00012 22.3 1.5 3.0 2 0 0 2 2 2 2 Zinc finger, C2H2 type Zn_clus PF00172.18 EXF81014.1 - 6.1e-05 23.0 11.3 6.1e-05 23.0 11.3 2.4 3 0 0 3 3 3 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-H2C2_2 PF13465.6 EXF81014.1 - 0.0017 18.7 1.7 0.0017 18.7 1.7 3.5 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 EXF81014.1 - 0.039 14.8 1.2 0.039 14.8 1.2 3.4 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EXF81014.1 - 0.094 13.0 3.0 0.74 10.2 0.7 2.6 1 1 1 2 2 2 0 Zinc-finger double-stranded RNA-binding NTS_2 PF15448.6 EXF81014.1 - 0.12 12.8 0.0 0.36 11.2 0.0 1.7 1 0 0 1 1 1 0 N-terminal segments of P. falciparum erythrocyte membrane protein zf-met PF12874.7 EXF81014.1 - 0.59 10.6 3.0 28 5.3 0.2 2.8 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2HC_2 PF13913.6 EXF81014.1 - 1.9 8.5 5.7 0.45 10.5 0.3 2.8 3 0 0 3 3 3 0 zinc-finger of a C2HC-type zf-C2H2_11 PF16622.5 EXF81014.1 - 5.9 6.7 7.0 31 4.4 0.1 3.1 2 0 0 2 2 2 0 zinc-finger C2H2-type adh_short_C2 PF13561.6 EXF81015.1 - 3.1e-53 180.8 0.5 5.5e-53 179.9 0.5 1.4 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF81015.1 - 1.3e-48 165.0 0.5 1.7e-48 164.7 0.5 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EXF81015.1 - 2.8e-10 40.4 0.4 4.2e-10 39.8 0.4 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EXF81015.1 - 0.046 13.2 0.1 0.16 11.4 0.1 1.8 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Zn_clus PF00172.18 EXF81016.1 - 3.1e-07 30.4 8.6 3.1e-07 30.4 8.6 2.0 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Cyclin PF08613.11 EXF81017.1 - 3.7e-07 30.6 0.5 1.3e-06 28.9 0.0 2.2 2 0 0 2 2 2 1 Cyclin Cyclin_N PF00134.23 EXF81017.1 - 0.079 12.7 0.0 0.18 11.6 0.0 1.6 1 1 0 1 1 1 0 Cyclin, N-terminal domain JmjC PF02373.22 EXF81018.1 - 7.5e-37 126.3 0.5 2e-36 124.9 0.5 1.8 1 0 0 1 1 1 1 JmjC domain, hydroxylase zf-HC5HC2H_2 PF13832.6 EXF81018.1 - 2.4e-21 75.9 5.4 4.3e-21 75.1 5.4 1.4 1 0 0 1 1 1 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 EXF81018.1 - 8.9e-21 73.9 5.4 8.9e-21 73.9 5.4 2.3 2 0 0 2 2 2 1 PHD-like zinc-binding domain JmjN PF02375.17 EXF81018.1 - 1.1e-13 50.8 0.3 2.8e-13 49.6 0.3 1.7 1 0 0 1 1 1 1 jmjN domain PAP2 PF01569.21 EXF81019.1 - 1.2e-19 70.4 0.9 1.2e-19 70.4 0.9 2.2 2 0 0 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.6 EXF81019.1 - 0.00039 20.2 2.2 0.00039 20.2 2.2 2.3 3 0 0 3 3 3 1 PAP2 superfamily Peptidase_U4 PF03419.13 EXF81019.1 - 0.19 11.0 1.8 0.19 11.0 0.1 1.8 2 0 0 2 2 2 0 Sporulation factor SpoIIGA adh_short_C2 PF13561.6 EXF81020.1 - 3.1e-48 164.4 1.0 7e-43 146.8 0.0 2.0 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF81020.1 - 1.2e-44 152.1 0.5 1.1e-34 119.6 0.0 2.0 1 1 1 2 2 2 2 short chain dehydrogenase KR PF08659.10 EXF81020.1 - 1.9e-10 41.0 0.2 3.4e-10 40.1 0.2 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EXF81020.1 - 3e-05 23.6 1.0 0.0001 21.9 0.2 2.1 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EXF81020.1 - 0.0052 15.9 0.0 0.15 11.1 0.0 2.1 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein 3HCDH_N PF02737.18 EXF81020.1 - 0.043 13.7 0.0 0.063 13.2 0.0 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain F420_oxidored PF03807.17 EXF81020.1 - 0.071 13.7 0.0 0.19 12.4 0.0 1.7 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent GDP_Man_Dehyd PF16363.5 EXF81020.1 - 0.12 11.8 0.4 4 6.7 0.4 2.3 1 1 0 1 1 1 0 GDP-mannose 4,6 dehydratase DFP PF04127.15 EXF81020.1 - 0.15 11.9 0.2 9 6.1 0.0 2.3 2 1 0 2 2 2 0 DNA / pantothenate metabolism flavoprotein ThiF PF00899.21 EXF81021.1 - 5.8e-75 251.8 0.0 9.9e-75 251.0 0.0 1.3 1 0 0 1 1 1 1 ThiF family UAE_UbL PF14732.6 EXF81021.1 - 3.1e-25 88.6 2.3 1.7e-24 86.3 0.4 2.4 2 0 0 2 2 2 1 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain UBA_e1_thiolCys PF10585.9 EXF81021.1 - 1.5e-05 25.0 9.4 3e-05 24.1 0.3 3.4 2 1 1 3 3 3 1 Ubiquitin-activating enzyme active site NAD_binding_7 PF13241.6 EXF81021.1 - 0.0008 19.8 0.1 0.0024 18.3 0.1 1.8 1 0 0 1 1 1 1 Putative NAD(P)-binding Shikimate_DH PF01488.20 EXF81021.1 - 0.063 13.3 0.1 0.15 12.1 0.1 1.7 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Pyr_redox PF00070.27 EXF81021.1 - 0.12 12.9 0.2 4.2 8.0 0.1 2.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Sacchrp_dh_NADP PF03435.18 EXF81021.1 - 0.16 12.3 0.3 0.65 10.3 0.3 2.1 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain DASH_Dam1 PF08653.10 EXF81021.1 - 0.19 11.5 0.5 2.6 7.9 0.2 2.5 2 0 0 2 2 2 0 DASH complex subunit Dam1 Pex14_N PF04695.13 EXF81021.1 - 2.4 8.8 23.2 0.06 14.0 15.7 2.0 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region TFIIA PF03153.13 EXF81021.1 - 8.9 6.2 24.0 20 5.0 24.0 1.5 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Q_salvage PF10343.9 EXF81022.1 - 1.7e-128 428.1 0.0 2.1e-128 427.8 0.0 1.1 1 0 0 1 1 1 1 Potential Queuosine, Q, salvage protein family DUF1563 PF07599.11 EXF81022.1 - 0.04 14.0 0.1 0.083 13.0 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1563) DNA_pol_delta_4 PF04081.13 EXF81023.1 - 5e-45 153.1 1.5 6.6e-45 152.6 1.5 1.3 1 1 0 1 1 1 1 DNA polymerase delta, subunit 4 DUF2031 PF09592.10 EXF81023.1 - 0.08 12.5 0.7 0.14 11.6 0.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2031) WD40 PF00400.32 EXF81024.1 - 8.7e-18 64.4 13.7 7.3e-08 33.0 0.5 6.4 7 0 0 7 7 7 3 WD domain, G-beta repeat Ank_4 PF13637.6 EXF81024.1 - 5e-14 52.5 0.1 2.3e-06 28.0 0.0 4.4 3 2 1 4 4 4 2 Ankyrin repeats (many copies) ANAPC4_WD40 PF12894.7 EXF81024.1 - 1.9e-12 47.3 2.6 0.0023 18.2 0.0 4.4 1 1 3 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Ank_2 PF12796.7 EXF81024.1 - 5.6e-11 42.9 0.0 3e-08 34.1 0.0 3.2 3 0 0 3 3 3 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EXF81024.1 - 1.3e-10 40.6 0.7 0.035 14.6 0.0 6.0 6 0 0 6 6 6 2 Ankyrin repeat Ank PF00023.30 EXF81024.1 - 1.5e-10 41.0 0.1 0.014 15.8 0.0 4.3 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 EXF81024.1 - 1.6e-09 37.8 0.1 6.9e-08 32.6 0.1 3.3 3 0 0 3 3 3 1 Ankyrin repeats (many copies) WD40_like PF17005.5 EXF81024.1 - 0.0017 17.8 0.0 0.0054 16.1 0.0 1.8 2 0 0 2 2 2 1 WD40-like domain eIF2A PF08662.11 EXF81024.1 - 0.013 15.4 0.1 0.049 13.5 0.0 2.0 1 1 1 2 2 2 0 Eukaryotic translation initiation factor eIF2A Nbas_N PF15492.6 EXF81024.1 - 0.034 13.5 0.1 1.4 8.2 0.0 2.8 2 1 1 3 3 3 0 Neuroblastoma-amplified sequence, N terminal Lactonase PF10282.9 EXF81024.1 - 0.058 12.6 0.0 0.72 9.1 0.0 2.1 1 1 1 2 2 2 0 Lactonase, 7-bladed beta-propeller Ge1_WD40 PF16529.5 EXF81024.1 - 0.06 12.3 0.3 6.3 5.7 0.0 3.1 2 2 2 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Ribosomal_L32p PF01783.23 EXF81025.1 - 2.7e-14 53.1 7.1 3.8e-14 52.7 7.1 1.2 1 0 0 1 1 1 1 Ribosomal L32p protein family zf-ribbon_3 PF13248.6 EXF81025.1 - 0.023 14.1 6.2 0.038 13.4 6.2 1.3 1 0 0 1 1 1 0 zinc-ribbon domain DUF4428 PF14471.6 EXF81025.1 - 0.049 13.6 0.2 0.049 13.6 0.2 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4428) HypA PF01155.19 EXF81025.1 - 0.049 13.6 0.1 0.057 13.4 0.1 1.2 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Septin PF00735.18 EXF81026.1 - 2e-112 375.1 0.7 2.4e-112 374.8 0.7 1.0 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 EXF81026.1 - 1.1e-07 32.0 0.0 2.2e-07 30.9 0.0 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EXF81026.1 - 4.4e-06 26.4 0.2 0.0031 17.1 0.0 2.3 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain AIG1 PF04548.16 EXF81026.1 - 4.9e-06 26.0 0.0 8.6e-06 25.2 0.0 1.4 1 0 0 1 1 1 1 AIG1 family RsgA_GTPase PF03193.16 EXF81026.1 - 1.1e-05 25.4 0.2 0.00032 20.6 0.1 2.3 2 0 0 2 2 2 1 RsgA GTPase Dynamin_N PF00350.23 EXF81026.1 - 0.001 19.1 0.2 1.5 8.9 0.1 2.6 1 1 1 2 2 2 2 Dynamin family NB-ARC PF00931.22 EXF81026.1 - 0.0032 16.7 0.1 0.0057 15.9 0.1 1.3 1 0 0 1 1 1 1 NB-ARC domain AAA_7 PF12775.7 EXF81026.1 - 0.0051 16.4 0.0 0.034 13.7 0.0 2.2 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_16 PF13191.6 EXF81026.1 - 0.0056 17.1 0.0 0.027 14.8 0.0 2.0 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EXF81026.1 - 0.0061 16.8 0.0 0.015 15.6 0.0 1.7 1 1 0 1 1 1 1 AAA domain ABC_tran PF00005.27 EXF81026.1 - 0.01 16.3 0.2 0.019 15.5 0.2 1.7 1 1 0 1 1 1 0 ABC transporter Gtr1_RagA PF04670.12 EXF81026.1 - 0.01 15.2 0.1 0.4 10.0 0.0 2.2 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region G-alpha PF00503.20 EXF81026.1 - 0.065 12.4 0.6 0.27 10.4 0.5 2.0 1 1 0 1 1 1 0 G-protein alpha subunit FtsK_SpoIIIE PF01580.18 EXF81026.1 - 0.077 12.3 0.1 0.15 11.4 0.1 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family Microtub_bd PF16796.5 EXF81026.1 - 0.078 12.9 0.2 0.51 10.3 0.0 2.1 2 0 0 2 2 2 0 Microtubule binding Roc PF08477.13 EXF81026.1 - 0.1 12.8 0.0 0.21 11.8 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase DUF1542 PF07564.11 EXF81026.1 - 0.12 12.5 0.1 0.28 11.3 0.1 1.6 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1542) T2SSE PF00437.20 EXF81026.1 - 0.13 11.3 0.0 0.25 10.4 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_29 PF13555.6 EXF81026.1 - 0.19 11.5 0.0 0.39 10.5 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Guanylate_kin PF00625.21 EXF81027.1 - 2.1e-62 210.0 0.0 2.6e-62 209.7 0.0 1.0 1 0 0 1 1 1 1 Guanylate kinase AAA_33 PF13671.6 EXF81027.1 - 9.3e-06 25.9 0.0 0.00013 22.1 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EXF81027.1 - 3.9e-05 24.2 0.2 0.00015 22.3 0.2 1.9 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EXF81027.1 - 6.8e-05 23.3 0.1 0.00023 21.6 0.1 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EXF81027.1 - 0.0021 18.3 0.0 0.005 17.1 0.0 1.6 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 EXF81027.1 - 0.01 15.9 0.0 0.03 14.4 0.0 1.8 1 1 0 1 1 1 0 50S ribosome-binding GTPase dNK PF01712.19 EXF81027.1 - 0.014 15.3 0.0 2.5 7.9 0.0 2.2 2 0 0 2 2 2 0 Deoxynucleoside kinase ATPase_2 PF01637.18 EXF81027.1 - 0.026 14.5 0.1 1.6 8.6 0.0 2.1 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea RsgA_GTPase PF03193.16 EXF81027.1 - 0.028 14.3 0.0 0.06 13.3 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase AAA_28 PF13521.6 EXF81027.1 - 0.069 13.4 0.0 1.3 9.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain Rad17 PF03215.15 EXF81027.1 - 0.072 13.0 0.0 0.087 12.7 0.0 1.2 1 0 0 1 1 1 0 Rad17 P-loop domain ABC_tran PF00005.27 EXF81027.1 - 0.098 13.2 0.1 0.15 12.6 0.1 1.7 1 1 0 1 1 1 0 ABC transporter AAA_14 PF13173.6 EXF81027.1 - 0.14 12.2 0.0 0.62 10.1 0.0 2.0 2 0 0 2 2 2 0 AAA domain Glyco_hydro_72 PF03198.14 EXF81028.1 - 1.1e-121 405.9 0.4 1.4e-121 405.6 0.4 1.0 1 0 0 1 1 1 1 Glucanosyltransferase Cellulase PF00150.18 EXF81028.1 - 0.00021 20.8 0.0 0.0011 18.5 0.0 1.9 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Citrate_bind PF16114.5 EXF81029.1 - 7.1e-88 292.7 0.0 9.9e-88 292.3 0.0 1.2 1 0 0 1 1 1 1 ATP citrate lyase citrate-binding ATP-grasp_2 PF08442.10 EXF81029.1 - 2.8e-08 33.6 0.0 4.3e-08 32.9 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain Reovirus_M2 PF05993.12 EXF81029.1 - 0.0015 16.8 0.0 0.0022 16.2 0.0 1.2 1 0 0 1 1 1 1 Reovirus major virion structural protein Mu-1/Mu-1C (M2) Citrate_synt PF00285.21 EXF81030.1 - 3.1e-21 75.9 0.0 3.6e-18 65.8 0.0 2.8 1 1 1 2 2 2 2 Citrate synthase, C-terminal domain CoA_binding PF02629.19 EXF81030.1 - 3.9e-19 69.1 0.1 2.5e-18 66.5 0.0 2.2 2 0 0 2 2 2 1 CoA binding domain Ligase_CoA PF00549.19 EXF81030.1 - 3.8e-14 52.8 0.1 6.4e-14 52.0 0.1 1.4 1 0 0 1 1 1 1 CoA-ligase Succ_CoA_lig PF13607.6 EXF81030.1 - 5.5e-06 26.2 0.0 9.7e-05 22.2 0.0 2.3 2 0 0 2 2 2 1 Succinyl-CoA ligase like flavodoxin domain Ribosomal_L30 PF00327.20 EXF81031.1 - 1.1e-16 60.5 0.1 1.4e-16 60.1 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e MRG PF05712.13 EXF81032.1 - 1.7e-63 213.5 0.1 2.4e-63 213.1 0.1 1.1 1 0 0 1 1 1 1 MRG Cnl2_NKP2 PF09447.10 EXF81033.1 - 3.4e-26 91.2 2.7 1e-25 89.6 0.9 2.1 2 0 0 2 2 2 1 Cnl2/NKP2 family protein DUF4407 PF14362.6 EXF81033.1 - 0.0097 15.3 2.3 0.012 15.0 2.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) DASH_Spc19 PF08287.11 EXF81033.1 - 0.014 15.3 5.1 0.082 12.8 0.0 2.2 2 0 0 2 2 2 0 Spc19 GP24_25 PF17388.2 EXF81033.1 - 0.014 15.4 0.8 0.21 11.6 0.6 2.1 1 1 1 2 2 2 0 Tail assembly gene products 24 & 25 DUF5082 PF16888.5 EXF81033.1 - 0.037 14.3 6.1 0.092 13.0 1.5 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF5082) Nnf1 PF03980.14 EXF81033.1 - 0.083 13.3 5.8 0.11 12.9 2.3 2.3 2 1 0 2 2 2 0 Nnf1 YabA PF06156.13 EXF81033.1 - 0.1 13.2 3.4 6.5 7.5 1.2 2.2 2 0 0 2 2 2 0 Initiation control protein YabA Prefoldin_2 PF01920.20 EXF81033.1 - 0.1 12.5 0.2 0.1 12.5 0.2 2.3 2 1 0 2 2 2 0 Prefoldin subunit Transposase_22 PF02994.14 EXF81033.1 - 0.22 11.7 3.4 0.23 11.7 1.6 1.9 1 1 1 2 2 2 0 L1 transposable element RBD-like domain HAUS-augmin3 PF14932.6 EXF81033.1 - 0.25 10.9 3.6 0.15 11.6 0.2 1.9 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 3 DivIC PF04977.15 EXF81033.1 - 0.45 10.3 0.1 0.45 10.3 0.1 2.4 2 1 0 2 2 2 0 Septum formation initiator DUF2968 PF11180.8 EXF81033.1 - 0.49 10.0 9.9 0.89 9.2 4.6 2.0 1 1 0 2 2 2 0 Protein of unknown function (DUF2968) V_ATPase_I PF01496.19 EXF81033.1 - 0.54 8.1 2.0 0.71 7.7 2.0 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Mis12 PF05859.12 EXF81033.1 - 0.58 10.2 3.4 1.6 8.8 0.5 2.5 1 1 1 2 2 2 0 Mis12 protein PspA_IM30 PF04012.12 EXF81033.1 - 0.66 9.5 11.8 4.6 6.8 11.7 2.0 1 1 0 1 1 1 0 PspA/IM30 family Qua1 PF16274.5 EXF81033.1 - 1.5 8.7 4.1 19 5.2 0.2 2.5 2 0 0 2 2 2 0 Qua1 domain Prominin PF05478.11 EXF81033.1 - 2.5 5.9 4.0 4.1 5.3 0.4 1.9 1 1 1 2 2 2 0 Prominin SPT2 PF08243.11 EXF81033.1 - 3.1 8.4 8.8 0.33 11.5 3.1 2.0 2 0 0 2 2 2 0 SPT2 chromatin protein DUF1192 PF06698.11 EXF81033.1 - 3.9 7.6 12.1 0.2 11.7 0.9 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF1192) M PF02370.16 EXF81033.1 - 6.5 7.7 8.0 0.72 10.6 1.7 2.7 3 0 0 3 3 2 0 M protein repeat DUF4140 PF13600.6 EXF81033.1 - 8.9 6.8 10.0 3.6 8.1 0.9 2.4 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) Ribosomal_60s PF00428.19 EXF81034.1 - 6.1 7.5 8.6 21 5.8 1.5 2.4 2 0 0 2 2 2 0 60s Acidic ribosomal protein CENP-Q PF13094.6 EXF81035.1 - 4.2e-52 176.7 0.4 4.2e-52 176.7 0.4 4.5 3 2 0 3 3 3 1 CENP-Q, a CENPA-CAD centromere complex subunit Methyltransf_11 PF08241.12 EXF81039.1 - 8.7e-07 29.5 0.0 0.0012 19.4 0.0 2.4 1 1 1 2 2 2 2 Methyltransferase domain Methyltransf_25 PF13649.6 EXF81039.1 - 7.1e-06 26.6 0.0 0.0096 16.6 0.0 2.4 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_23 PF13489.6 EXF81039.1 - 0.00021 21.2 0.0 0.00053 19.9 0.0 1.7 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF81039.1 - 0.005 17.6 0.0 0.024 15.4 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF81039.1 - 0.024 14.4 0.0 0.64 9.8 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase domain Myb_DNA-binding PF00249.31 EXF81040.1 - 1.3e-14 54.1 2.2 4.6e-11 42.7 0.0 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EXF81040.1 - 1.1e-05 25.6 4.1 0.0047 17.2 0.1 2.7 3 0 0 3 3 3 2 Myb-like DNA-binding domain Ubiquitin_2 PF14560.6 EXF81041.1 - 4.8e-22 78.2 0.0 9.1e-22 77.3 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-like domain CAP_GLY PF01302.25 EXF81041.1 - 7e-22 77.2 1.7 1e-21 76.7 1.7 1.3 1 0 0 1 1 1 1 CAP-Gly domain ubiquitin PF00240.23 EXF81041.1 - 0.00064 19.4 0.0 0.0015 18.3 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin family T6_Ig_like PF18002.1 EXF81041.1 - 0.068 13.1 0.0 0.11 12.4 0.0 1.2 1 0 0 1 1 1 0 T6 antigen Ig like domain CAS_CSE1 PF03378.15 EXF81042.1 - 3.8e-170 566.2 3.2 3.5e-169 563.0 0.5 2.3 2 0 0 2 2 2 2 CAS/CSE protein, C-terminus Cse1 PF08506.10 EXF81042.1 - 3.3e-157 523.0 3.4 6.6e-157 522.1 3.4 1.5 1 0 0 1 1 1 1 Cse1 IBN_N PF03810.19 EXF81042.1 - 1.5e-15 56.9 0.4 7.4e-15 54.6 0.1 2.4 2 0 0 2 2 2 1 Importin-beta N-terminal domain V-ATPase_H_N PF03224.14 EXF81042.1 - 0.00051 19.4 0.4 1.2 8.4 0.0 4.2 4 2 0 4 4 4 1 V-ATPase subunit H Antiterm PF03589.13 EXF81042.1 - 0.15 12.4 0.0 2.5 8.5 0.0 2.9 2 0 0 2 2 2 0 Antitermination protein Xpo1 PF08389.12 EXF81042.1 - 0.61 10.1 4.7 2.6 8.1 0.5 3.9 3 2 0 3 3 3 0 Exportin 1-like protein DUF3384 PF11864.8 EXF81043.1 - 1.2e-132 443.3 0.1 1.2e-132 443.3 0.1 2.1 2 1 0 2 2 2 1 Domain of unknown function (DUF3384) Rap_GAP PF02145.15 EXF81043.1 - 7.9e-53 178.8 0.0 1.4e-52 177.9 0.0 1.5 1 0 0 1 1 1 1 Rap/ran-GAP Tuberin PF03542.16 EXF81043.1 - 1e-39 136.7 8.5 6.7e-37 127.4 3.3 3.1 3 0 0 3 3 3 2 Tuberin Acetyltransf_1 PF00583.25 EXF81044.1 - 4.3e-07 30.2 0.0 1.4e-06 28.5 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EXF81044.1 - 0.00041 20.3 0.0 0.0025 17.7 0.0 2.2 3 0 0 3 3 3 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EXF81044.1 - 0.0021 18.5 0.0 0.0052 17.2 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain CENP-I PF07778.11 EXF81045.1 - 3e-34 118.6 0.0 4.3e-33 114.8 0.0 2.0 1 1 0 1 1 1 1 Mis6 PKHD_C PF18331.1 EXF81045.1 - 0.0025 17.9 0.0 0.042 13.9 0.0 2.5 2 0 0 2 2 2 1 PKHD-type hydroxylase C-terminal domain ABC_tran PF00005.27 EXF81046.1 - 6.6e-16 59.1 0.1 6.5e-15 55.8 0.1 2.1 1 1 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 EXF81046.1 - 1.8e-10 41.1 1.1 0.00012 22.0 0.2 2.2 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EXF81046.1 - 0.0014 18.3 0.2 0.0037 17.0 0.2 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain DUF3584 PF12128.8 EXF81046.1 - 0.0019 15.9 0.2 0.0024 15.5 0.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) SMC_N PF02463.19 EXF81046.1 - 0.0024 17.3 0.1 2.1 7.7 0.0 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EXF81046.1 - 0.0041 17.6 0.1 0.0058 17.1 0.1 1.2 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.6 EXF81046.1 - 0.013 15.7 0.2 0.027 14.7 0.2 1.5 1 0 0 1 1 1 0 AAA domain AAA_15 PF13175.6 EXF81046.1 - 0.016 14.9 0.1 0.022 14.5 0.1 1.1 1 0 0 1 1 1 0 AAA ATPase domain AAA_16 PF13191.6 EXF81046.1 - 0.018 15.5 0.7 0.027 14.8 0.7 1.5 1 1 0 1 1 1 0 AAA ATPase domain RsgA_GTPase PF03193.16 EXF81046.1 - 0.021 14.8 0.1 0.03 14.2 0.1 1.2 1 0 0 1 1 1 0 RsgA GTPase AAA_22 PF13401.6 EXF81046.1 - 0.025 14.9 0.1 0.13 12.5 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 EXF81046.1 - 0.034 13.7 0.2 0.084 12.4 0.1 1.6 1 1 0 1 1 1 0 AAA domain PduV-EutP PF10662.9 EXF81046.1 - 0.036 13.8 0.1 0.054 13.2 0.1 1.2 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation SRP54 PF00448.22 EXF81046.1 - 0.04 13.6 0.1 0.056 13.1 0.1 1.4 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain Arf PF00025.21 EXF81046.1 - 0.068 12.6 0.2 0.15 11.5 0.2 1.7 1 1 0 1 1 1 0 ADP-ribosylation factor family AAA PF00004.29 EXF81046.1 - 0.12 12.8 0.5 0.41 11.1 0.5 2.0 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_13 PF13166.6 EXF81046.1 - 0.14 10.8 0.0 0.19 10.3 0.0 1.1 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EXF81046.1 - 0.15 12.2 0.1 0.31 11.2 0.1 1.5 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 EXF81046.1 - 0.18 11.7 0.1 0.29 11.0 0.1 1.3 1 0 0 1 1 1 0 NACHT domain T2SSE PF00437.20 EXF81046.1 - 0.24 10.4 0.1 0.35 9.9 0.1 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein DNA_pol_E_B PF04042.16 EXF81047.1 - 6.1e-39 133.6 0.6 1.9e-36 125.4 0.6 2.3 1 1 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B DNA_pol_D_N PF18018.1 EXF81047.1 - 3.2e-37 127.5 0.0 5.4e-37 126.8 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase delta subunit OB-fold domain DUF4334 PF14232.6 EXF81047.1 - 0.25 11.3 1.8 0.3 11.1 0.3 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4334) Ecl1 PF12855.7 EXF81047.1 - 6.8 7.8 12.3 0.75 10.9 6.8 2.0 2 0 0 2 2 2 0 ECL1/2/3 zinc binding proteins PALP PF00291.25 EXF81049.1 - 3e-65 220.6 2.9 3.4e-65 220.4 2.9 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Aminotran_1_2 PF00155.21 EXF81049.1 - 0.041 13.1 0.0 0.11 11.6 0.0 1.7 2 0 0 2 2 2 0 Aminotransferase class I and II tRNA-synt_1g PF09334.11 EXF81050.1 - 4.1e-97 325.4 0.6 3.2e-96 322.5 0.6 2.0 1 1 0 1 1 1 1 tRNA synthetases class I (M) Acetyltransf_3 PF13302.7 EXF81050.1 - 1.6e-23 83.9 0.3 4.2e-23 82.5 0.1 1.9 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain tRNA-synt_1 PF00133.22 EXF81050.1 - 3.4e-21 75.2 6.1 1e-09 37.3 0.1 3.8 1 1 2 3 3 3 3 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.19 EXF81050.1 - 2e-09 37.3 0.1 0.00013 21.4 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain Acetyltransf_1 PF00583.25 EXF81050.1 - 3.9e-05 23.8 0.4 0.0028 17.9 0.2 2.8 1 1 0 2 2 2 1 Acetyltransferase (GNAT) family FR47 PF08445.10 EXF81050.1 - 0.00033 20.6 0.3 0.56 10.2 0.0 2.6 1 1 1 2 2 2 2 FR47-like protein Acetyltransf_8 PF13523.6 EXF81050.1 - 0.00066 19.4 1.9 4.7 6.9 0.0 3.5 3 0 0 3 3 3 2 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EXF81050.1 - 0.0063 16.9 0.0 0.021 15.3 0.0 1.9 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain ESCRT-II PF05871.12 EXF81050.1 - 0.04 14.2 0.1 0.1 12.9 0.1 1.7 1 0 0 1 1 1 0 ESCRT-II complex subunit NTF2 PF02136.20 EXF81051.1 - 0.0061 17.1 0.0 0.02 15.5 0.0 1.8 1 1 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain PPTA PF01239.22 EXF81052.1 - 4.8e-37 124.6 20.7 5.8e-08 32.2 0.2 5.4 5 0 0 5 5 5 5 Protein prenyltransferase alpha subunit repeat TPR_14 PF13428.6 EXF81052.1 - 0.013 16.2 2.2 0.18 12.7 0.7 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 EXF81052.1 - 0.068 13.3 1.1 0.27 11.4 1.1 2.1 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_19 PF14559.6 EXF81052.1 - 0.098 13.2 2.6 1.6 9.3 1.1 3.0 2 1 1 3 3 3 0 Tetratricopeptide repeat GHMP_kinases_N PF00288.26 EXF81054.1 - 2e-17 63.2 0.0 4.8e-17 61.9 0.0 1.6 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 EXF81054.1 - 1e-08 35.4 0.0 2.7e-08 34.1 0.0 1.7 1 0 0 1 1 1 1 GHMP kinases C terminal GalKase_gal_bdg PF10509.9 EXF81054.1 - 0.002 17.6 0.0 0.005 16.4 0.0 1.7 1 0 0 1 1 1 1 Galactokinase galactose-binding signature ABM PF03992.16 EXF81055.1 - 3e-08 33.6 4.7 0.0015 18.6 0.0 3.0 2 1 0 2 2 2 2 Antibiotic biosynthesis monooxygenase DUF4679 PF15728.5 EXF81055.1 - 0.071 12.1 0.0 0.084 11.9 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4679) Ribosomal_L38e PF01781.18 EXF81056.1 - 3.8e-33 113.4 3.5 4.3e-33 113.2 3.5 1.1 1 0 0 1 1 1 1 Ribosomal L38e protein family LAGLIDADG_WhiA PF14527.6 EXF81056.1 - 0.036 14.1 0.1 0.042 13.9 0.1 1.1 1 0 0 1 1 1 0 WhiA LAGLIDADG-like domain Ish1 PF10281.9 EXF81057.1 - 8.1e-05 22.8 0.1 0.00017 21.8 0.0 1.6 2 0 0 2 2 2 1 Putative stress-responsive nuclear envelope protein Mac PF12464.8 EXF81057.1 - 0.075 13.3 0.7 0.17 12.2 0.7 1.5 1 0 0 1 1 1 0 Maltose acetyltransferase DNA_meth_N PF18284.1 EXF81057.1 - 1.2 9.1 3.5 1.7 8.6 2.3 1.9 1 1 1 2 2 2 0 DNA methylase N-terminal domain Peptidase_M48_N PF16491.5 EXF81058.1 - 4.1e-67 225.6 9.1 4.1e-67 225.6 9.1 1.7 2 0 0 2 2 2 1 CAAX prenyl protease N-terminal, five membrane helices Peptidase_M48 PF01435.18 EXF81058.1 - 7.6e-45 153.1 0.1 1.4e-44 152.2 0.1 1.4 1 0 0 1 1 1 1 Peptidase family M48 Peptidase_M56 PF05569.11 EXF81058.1 - 0.031 13.5 0.1 0.063 12.5 0.1 1.5 1 0 0 1 1 1 0 BlaR1 peptidase M56 Ribosomal_L34 PF00468.17 EXF81059.1 - 5.8e-13 48.6 11.1 1.1e-12 47.7 11.1 1.5 1 0 0 1 1 1 1 Ribosomal protein L34 VMR2 PF17055.5 EXF81060.1 - 0.091 12.5 0.0 0.13 12.0 0.0 1.1 1 0 0 1 1 1 0 Viral matrix protein M2 Glyco_hydro_3 PF00933.21 EXF81061.1 - 1.1e-44 153.1 0.0 1.8e-44 152.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.22 EXF81061.1 - 8e-41 140.2 0.0 2.6e-40 138.6 0.0 1.9 2 1 0 2 2 2 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.6 EXF81061.1 - 3.6e-23 81.5 0.1 7.1e-23 80.5 0.1 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain CARDB PF07705.11 EXF81061.1 - 0.027 14.7 0.0 0.078 13.2 0.0 1.7 1 0 0 1 1 1 0 CARDB Lipase_3 PF01764.25 EXF81062.1 - 1.1e-35 122.6 0.0 1.8e-35 121.9 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_8 PF06259.12 EXF81062.1 - 0.0043 16.7 0.1 0.0099 15.5 0.1 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase Hydrolase_4 PF12146.8 EXF81062.1 - 0.0079 15.5 0.0 0.014 14.6 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EXF81062.1 - 0.0081 16.8 0.1 0.011 16.4 0.1 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family SNF2_N PF00176.23 EXF81063.1 - 1.3e-49 168.8 0.6 1.3e-44 152.4 0.1 2.7 3 1 0 3 3 3 2 SNF2 family N-terminal domain Helicase_C PF00271.31 EXF81063.1 - 1e-16 61.2 0.0 1e-15 58.0 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EXF81063.1 - 2.3e-08 34.2 1.3 4.4e-08 33.3 0.1 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit zf-C3HC4 PF00097.25 EXF81063.1 - 9.8e-07 28.6 5.5 9.8e-07 28.6 5.5 1.9 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) AAA_34 PF13872.6 EXF81063.1 - 2.7e-05 23.2 0.0 0.0001 21.3 0.0 1.9 2 0 0 2 2 2 1 P-loop containing NTP hydrolase pore-1 zf-C3HC4_2 PF13923.6 EXF81063.1 - 0.00015 21.5 6.3 0.00015 21.5 6.3 1.9 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EXF81063.1 - 0.00056 19.7 6.6 0.00056 19.7 6.6 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EXF81063.1 - 0.0014 18.9 7.5 0.0014 18.9 7.5 2.5 2 0 0 2 2 2 1 Ring finger domain zf-RING_UBOX PF13445.6 EXF81063.1 - 0.64 10.1 6.6 1.9 8.6 6.6 1.9 1 0 0 1 1 1 0 RING-type zinc-finger Zn_Tnp_IS91 PF14319.6 EXF81063.1 - 0.73 9.9 7.3 1 9.4 0.7 2.5 2 0 0 2 2 2 0 Transposase zinc-binding domain AT_hook PF02178.19 EXF81063.1 - 2.3 8.3 27.7 0.95 9.6 5.6 5.0 4 0 0 4 4 4 0 AT hook motif LRR_8 PF13855.6 EXF81064.1 - 0.086 12.6 0.1 0.76 9.6 0.1 2.6 3 0 0 3 3 3 0 Leucine rich repeat LRR_4 PF12799.7 EXF81064.1 - 0.44 11.0 4.3 71 4.0 0.3 4.9 6 1 2 8 8 8 0 Leucine Rich repeats (2 copies) UCMA PF17085.5 EXF81064.1 - 0.53 10.3 4.0 1.7 8.7 4.0 1.8 1 0 0 1 1 1 0 Unique cartilage matrix associated protein TFIIA PF03153.13 EXF81064.1 - 4.5 7.2 15.9 5.9 6.8 15.9 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Agouti PF05039.12 EXF81064.1 - 7.6 7.3 6.7 5 7.9 2.2 2.9 1 1 2 3 3 3 0 Agouti protein DHHC PF01529.20 EXF81065.1 - 1.1e-37 129.1 9.7 1.9e-37 128.4 9.7 1.4 1 0 0 1 1 1 1 DHHC palmitoyltransferase DUF4064 PF13273.6 EXF81065.1 - 0.095 13.0 0.0 0.095 13.0 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) FtsX PF02687.21 EXF81065.1 - 7.1 7.2 8.1 51 4.4 8.1 2.2 1 1 0 1 1 1 0 FtsX-like permease family Ssl1 PF04056.14 EXF81066.1 - 7.7e-74 247.7 0.0 1.1e-73 247.2 0.0 1.2 1 0 0 1 1 1 1 Ssl1-like C1_4 PF07975.12 EXF81066.1 - 3.4e-16 59.2 9.4 3.4e-16 59.2 9.4 3.1 2 1 0 2 2 2 1 TFIIH C1-like domain VWA_2 PF13519.6 EXF81066.1 - 2.9e-15 56.8 0.0 6.1e-15 55.8 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 EXF81066.1 - 0.00055 20.2 0.0 0.00088 19.6 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain HypA PF01155.19 EXF81066.1 - 4.8 7.3 12.0 0.58 10.2 2.1 2.6 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Glyoxalase PF00903.25 EXF81067.1 - 1.9e-23 83.0 0.1 3.5e-15 56.3 0.0 2.2 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 EXF81067.1 - 1.5e-11 44.5 0.1 7.3e-05 23.0 0.1 2.4 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.6 EXF81067.1 - 5.4e-05 23.4 0.1 0.38 10.9 0.0 3.0 2 1 0 2 2 2 2 Glyoxalase-like domain Glyoxalase_5 PF14696.6 EXF81067.1 - 0.0013 18.9 0.0 0.0071 16.5 0.0 2.0 2 0 0 2 2 2 1 Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal TPR_17 PF13431.6 EXF81069.1 - 0.042 14.2 0.5 0.83 10.2 0.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TcdB_N PF12918.7 EXF81069.1 - 0.13 12.5 0.1 0.3 11.4 0.1 1.5 1 0 0 1 1 1 0 TcdB toxin N-terminal helical domain Ribosomal_L27e PF01777.18 EXF81070.1 - 4.3e-36 123.1 4.4 6.9e-36 122.5 4.4 1.3 1 0 0 1 1 1 1 Ribosomal L27e protein family TPT PF03151.16 EXF81071.1 - 7e-26 91.2 26.9 8.6e-26 90.9 26.9 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 EXF81071.1 - 0.00045 20.4 40.6 0.0097 16.1 13.0 2.4 3 0 0 3 3 3 2 EamA-like transporter family Amino_oxidase PF01593.24 EXF81072.1 - 1.4e-08 34.5 0.0 2.5e-08 33.7 0.0 1.5 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EXF81072.1 - 1.2e-07 31.9 0.1 2.9e-07 30.6 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EXF81072.1 - 0.00071 18.9 0.0 0.01 15.1 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EXF81072.1 - 0.013 14.8 0.1 0.02 14.2 0.1 1.2 1 0 0 1 1 1 0 FAD binding domain Pyr_redox_3 PF13738.6 EXF81072.1 - 0.044 13.0 0.1 0.082 12.1 0.1 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EXF81072.1 - 0.046 12.4 0.1 0.071 11.8 0.1 1.2 1 0 0 1 1 1 0 HI0933-like protein Lycopene_cycl PF05834.12 EXF81072.1 - 0.047 12.7 1.0 0.094 11.7 0.2 1.8 2 0 0 2 2 2 0 Lycopene cyclase protein Thi4 PF01946.17 EXF81072.1 - 0.049 12.9 0.7 0.091 12.0 0.1 1.7 2 0 0 2 2 2 0 Thi4 family FAD_binding_2 PF00890.24 EXF81072.1 - 0.1 11.7 0.2 0.15 11.1 0.2 1.2 1 0 0 1 1 1 0 FAD binding domain DAO PF01266.24 EXF81072.1 - 0.13 11.8 0.2 0.22 11.1 0.2 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase FAD_oxidored PF12831.7 EXF81072.1 - 0.14 11.5 0.0 0.2 11.0 0.0 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase GIDA PF01134.22 EXF81072.1 - 0.22 10.6 0.5 2.9 6.9 0.1 2.3 2 0 0 2 2 2 0 Glucose inhibited division protein A HATPase_c PF02518.26 EXF81074.1 - 6e-31 107.2 0.1 1.4e-30 106.1 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EXF81074.1 - 1.6e-21 76.5 0.2 4.2e-21 75.2 0.2 1.8 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 EXF81074.1 - 4.2e-19 68.3 0.2 1.5e-18 66.6 0.2 2.1 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain GAF_2 PF13185.6 EXF81074.1 - 2e-13 50.8 0.2 7.3e-13 49.0 0.0 2.1 2 0 0 2 2 1 1 GAF domain AAA_16 PF13191.6 EXF81074.1 - 4e-13 50.1 0.4 1.8e-12 48.0 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain Pkinase PF00069.25 EXF81074.1 - 2.4e-09 36.9 0.0 4.6e-08 32.8 0.0 2.3 2 0 0 2 2 2 1 Protein kinase domain GAF PF01590.26 EXF81074.1 - 1.5e-07 32.1 0.0 4.9e-07 30.5 0.0 2.0 1 0 0 1 1 1 1 GAF domain HATPase_c_3 PF13589.6 EXF81074.1 - 0.00017 21.5 0.0 0.00036 20.4 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase GAF_3 PF13492.6 EXF81074.1 - 0.0013 19.0 0.0 0.0042 17.4 0.0 2.0 1 0 0 1 1 1 1 GAF domain TPR_12 PF13424.6 EXF81074.1 - 0.014 15.7 13.9 0.045 14.0 0.1 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat Pkinase_Tyr PF07714.17 EXF81074.1 - 0.084 12.1 0.0 0.16 11.2 0.0 1.4 1 0 0 1 1 1 0 Protein tyrosine kinase NACHT PF05729.12 EXF81074.1 - 0.15 12.0 0.0 6.2 6.7 0.0 2.6 2 0 0 2 2 2 0 NACHT domain TPR_14 PF13428.6 EXF81074.1 - 2.8 9.0 7.4 19 6.4 0.1 4.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 EXF81074.1 - 4.7 7.6 8.4 0.81 10.0 0.2 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat zf-C2H2 PF00096.26 EXF81075.1 - 2.9e-20 71.5 31.2 4.1e-06 26.9 0.2 4.6 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EXF81075.1 - 3e-18 65.3 27.8 2.2e-06 27.8 0.6 5.2 5 0 0 5 5 5 4 Zinc-finger double domain zf-C2H2_4 PF13894.6 EXF81075.1 - 2.9e-09 37.0 27.9 0.014 16.2 1.2 4.8 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2_8 PF15909.5 EXF81075.1 - 0.0065 16.7 9.4 0.91 9.9 6.2 2.8 1 1 1 2 2 2 2 C2H2-type zinc ribbon zf-C2H2_11 PF16622.5 EXF81075.1 - 0.015 15.0 2.0 0.015 15.0 2.0 2.4 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-TRAF PF02176.18 EXF81075.1 - 0.033 14.9 2.3 0.033 14.9 2.3 3.3 1 1 2 3 3 3 0 TRAF-type zinc finger zf-met PF12874.7 EXF81075.1 - 0.037 14.4 1.0 0.037 14.4 1.0 4.9 6 0 0 6 6 6 0 Zinc-finger of C2H2 type FOXP-CC PF16159.5 EXF81075.1 - 0.04 14.5 10.9 7.5 7.3 0.3 4.7 2 1 2 4 4 4 0 FOXP coiled-coil domain zf-C2H2_jaz PF12171.8 EXF81075.1 - 0.07 13.4 11.4 0.51 10.7 0.5 4.1 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding zf-C2H2_aberr PF17017.5 EXF81075.1 - 8.6 6.5 11.2 3.4 7.8 0.1 3.5 1 1 3 4 4 4 0 Aberrant zinc-finger Peptidase_M41 PF01434.18 EXF81076.1 - 8.7e-58 195.3 0.8 1.5e-57 194.6 0.8 1.4 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 EXF81076.1 - 6.7e-43 146.3 0.0 1.6e-42 145.0 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EXF81076.1 - 9.6e-09 34.9 0.1 2.1e-08 33.8 0.1 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 EXF81076.1 - 5.2e-05 23.3 0.0 0.00019 21.4 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) TIP49 PF06068.13 EXF81076.1 - 6.9e-05 22.2 0.0 0.00013 21.3 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_16 PF13191.6 EXF81076.1 - 0.00051 20.5 1.9 0.0041 17.5 0.3 3.1 2 1 0 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 EXF81076.1 - 0.0012 18.7 0.0 0.0024 17.6 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EXF81076.1 - 0.0012 19.2 0.0 0.14 12.4 0.0 2.9 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EXF81076.1 - 0.0021 18.2 0.0 0.0053 16.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 EXF81076.1 - 0.0083 15.5 0.3 0.02 14.3 0.3 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 EXF81076.1 - 0.017 14.9 0.0 0.042 13.6 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_2 PF07724.14 EXF81076.1 - 0.026 14.6 0.0 0.073 13.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) Zeta_toxin PF06414.12 EXF81076.1 - 0.082 12.2 0.8 0.24 10.6 0.4 2.0 1 1 1 2 2 2 0 Zeta toxin AAA_25 PF13481.6 EXF81076.1 - 0.083 12.5 0.6 2.9 7.4 0.2 2.4 1 1 1 2 2 2 0 AAA domain AAA_17 PF13207.6 EXF81076.1 - 0.18 12.2 0.6 0.35 11.3 0.0 1.8 2 0 0 2 2 2 0 AAA domain adh_short_C2 PF13561.6 EXF81077.1 - 1.1e-54 185.4 2.6 1.4e-54 185.2 2.6 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF81077.1 - 4e-45 153.7 1.2 4.9e-45 153.4 1.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EXF81077.1 - 1.2e-10 41.6 0.5 3.5e-10 40.1 0.5 1.7 1 1 0 1 1 1 1 KR domain Dioxygenase_C PF00775.21 EXF81078.1 - 0.00017 21.1 0.1 0.00029 20.3 0.1 1.3 1 0 0 1 1 1 1 Dioxygenase Abhydrolase_1 PF00561.20 EXF81079.1 - 1.7e-17 63.9 0.1 8.8e-12 45.2 0.3 2.8 2 1 1 3 3 3 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EXF81079.1 - 2e-16 61.3 1.8 2.6e-16 60.9 1.8 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EXF81079.1 - 1.3e-12 47.5 0.1 6.2e-12 45.3 0.1 1.8 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Ribonuclease_3 PF00636.26 EXF81083.1 - 2.5e-45 153.4 0.1 2.4e-22 79.5 0.0 3.0 2 0 0 2 2 2 2 Ribonuclease III domain Ribonucleas_3_3 PF14622.6 EXF81083.1 - 1.1e-23 83.7 0.1 7.7e-09 35.8 0.0 3.7 3 0 0 3 3 3 3 Ribonuclease-III-like Dicer_dimer PF03368.14 EXF81083.1 - 5.6e-22 77.7 0.2 1.1e-19 70.3 0.2 3.4 3 0 0 3 3 3 1 Dicer dimerisation domain ResIII PF04851.15 EXF81083.1 - 1.6e-17 64.0 0.4 1e-16 61.4 0.2 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EXF81083.1 - 5.4e-17 62.1 0.0 1.5e-16 60.7 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EXF81083.1 - 4e-11 43.0 0.0 1.5e-10 41.2 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Flavi_DEAD PF07652.14 EXF81083.1 - 0.0083 16.1 0.1 0.025 14.5 0.1 1.8 1 0 0 1 1 1 1 Flavivirus DEAD domain DUF2192 PF09958.9 EXF81083.1 - 0.058 12.9 0.0 0.63 9.5 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2192) ERCC3_RAD25_C PF16203.5 EXF81083.1 - 0.092 11.9 0.0 0.19 10.9 0.0 1.4 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase TAP42 PF04177.12 EXF81084.1 - 1.3e-105 353.0 0.1 1.5e-105 352.8 0.1 1.0 1 0 0 1 1 1 1 TAP42-like family ELM2 PF01448.24 EXF81084.1 - 0.009 16.7 0.6 0.04 14.7 0.0 2.3 2 0 0 2 2 2 1 ELM2 domain Alliinase_C PF04864.13 EXF81085.1 - 0.032 13.1 0.2 0.054 12.4 0.2 1.2 1 0 0 1 1 1 0 Allinase HicA_toxin PF07927.12 EXF81086.1 - 0.027 14.5 0.0 0.06 13.4 0.0 1.6 1 0 0 1 1 1 0 HicA toxin of bacterial toxin-antitoxin, Drf_GBD PF06371.13 EXF81086.1 - 0.1 12.2 0.1 0.33 10.5 0.0 1.8 2 0 0 2 2 2 0 Diaphanous GTPase-binding Domain DUF1899 PF08953.11 EXF81087.1 - 0.085 12.7 0.0 0.099 12.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1899) CENP-B_dimeris PF09026.10 EXF81088.1 - 7.1 7.1 17.2 1.1 9.7 6.4 2.6 2 0 0 2 2 2 0 Centromere protein B dimerisation domain GCIP PF13324.6 EXF81088.1 - 9.6 5.7 5.6 1.9 8.0 0.4 2.3 3 0 0 3 3 3 0 Grap2 and cyclin-D-interacting CPSase_L_D2 PF02786.17 EXF81089.1 - 3.6e-112 373.0 0.2 1.5e-83 279.5 0.0 2.3 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_sm_chain PF00988.22 EXF81089.1 - 2.7e-46 156.6 0.0 6.8e-46 155.3 0.0 1.7 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain GATase PF00117.28 EXF81089.1 - 8.8e-46 156.1 0.0 2e-45 154.9 0.0 1.7 1 0 0 1 1 1 1 Glutamine amidotransferase class-I OTCace_N PF02729.21 EXF81089.1 - 1.3e-44 151.8 0.0 2.8e-44 150.7 0.0 1.6 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain CPSase_L_D3 PF02787.19 EXF81089.1 - 8.4e-41 139.1 0.1 2e-40 137.9 0.1 1.7 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain OTCace PF00185.24 EXF81089.1 - 6.9e-29 100.9 0.0 1.7e-28 99.7 0.0 1.7 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain MGS PF02142.22 EXF81089.1 - 2.2e-21 75.9 0.0 9.3e-21 73.8 0.0 2.2 2 0 0 2 2 2 1 MGS-like domain Dala_Dala_lig_C PF07478.13 EXF81089.1 - 1.6e-17 63.7 0.3 2.6e-08 33.6 0.1 2.4 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 EXF81089.1 - 6e-16 58.5 0.1 5.9e-08 32.5 0.1 2.4 2 0 0 2 2 2 2 ATP-grasp domain ATPgrasp_Ter PF15632.6 EXF81089.1 - 1.4e-09 37.8 0.0 0.00011 22.0 0.0 2.6 2 0 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon Peptidase_C26 PF07722.13 EXF81089.1 - 1.3e-05 25.1 0.8 0.0011 18.8 0.1 3.0 2 1 0 2 2 2 1 Peptidase C26 ATP-grasp_3 PF02655.14 EXF81089.1 - 1.9e-05 24.7 0.4 0.056 13.5 0.1 2.8 2 0 0 2 2 2 2 ATP-grasp domain DJ-1_PfpI PF01965.24 EXF81089.1 - 6.4e-05 22.8 0.1 0.069 12.9 0.0 3.7 3 0 0 3 3 3 1 DJ-1/PfpI family GARS_A PF01071.19 EXF81089.1 - 0.0033 17.2 0.3 2.7 7.7 0.0 3.0 3 0 0 3 3 3 2 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain PNP_phzG_C PF10590.9 EXF81090.1 - 1.2e-21 76.5 1.4 6e-21 74.3 1.5 2.2 2 0 0 2 2 2 1 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region Putative_PNPOx PF01243.20 EXF81090.1 - 2.5e-21 75.6 0.0 4.3e-21 74.9 0.0 1.3 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyridox_oxase_2 PF12766.7 EXF81090.1 - 0.00037 21.0 0.0 0.0012 19.4 0.0 1.9 1 1 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Flg_new PF09479.10 EXF81090.1 - 0.13 12.5 0.0 0.27 11.4 0.0 1.5 1 0 0 1 1 1 0 Listeria-Bacteroides repeat domain (List_Bact_rpt) Pyrid_ox_like PF16242.5 EXF81090.1 - 0.17 11.5 0.0 0.51 9.9 0.0 1.8 2 0 0 2 2 2 0 Pyridoxamine 5'-phosphate oxidase like Cyclin_N PF00134.23 EXF81091.1 - 1.7e-05 24.6 0.0 0.00019 21.2 0.0 2.1 2 0 0 2 2 2 1 Cyclin, N-terminal domain SnoaL PF07366.12 EXF81096.1 - 8.1e-06 25.6 0.1 0.16 11.7 0.0 2.8 2 1 0 2 2 2 2 SnoaL-like polyketide cyclase SnoaL_2 PF12680.7 EXF81096.1 - 1.7e-05 25.4 0.0 0.014 16.0 0.0 2.2 2 0 0 2 2 2 2 SnoaL-like domain Dot_icm_IcmQ PF09475.10 EXF81096.1 - 0.065 12.7 0.1 0.098 12.1 0.1 1.2 1 0 0 1 1 1 0 Dot/Icm secretion system protein (dot_icm_IcmQ) Methyltransf_23 PF13489.6 EXF81097.1 - 1e-12 48.2 0.0 4.6e-11 42.8 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF81097.1 - 0.00083 20.0 0.1 0.046 14.4 0.0 2.7 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF81097.1 - 0.001 18.9 0.0 0.045 13.6 0.0 2.3 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF81097.1 - 0.01 16.5 0.0 0.06 14.0 0.0 2.2 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.6 EXF81098.1 - 1.1e-17 64.3 0.0 1.6e-17 63.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF81098.1 - 1.2e-09 38.7 0.0 3.7e-09 37.2 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF81098.1 - 1.3e-09 38.0 0.0 2.2e-08 34.0 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF81098.1 - 1.9e-07 31.7 0.0 1.7e-06 28.7 0.0 2.4 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF81098.1 - 3e-07 31.0 0.0 7.7e-07 29.7 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_2 PF00891.18 EXF81098.1 - 0.007 15.7 0.0 0.02 14.2 0.0 1.7 2 0 0 2 2 2 1 O-methyltransferase domain MTS PF05175.14 EXF81098.1 - 0.007 15.9 0.0 0.011 15.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain CMAS PF02353.20 EXF81098.1 - 0.059 12.6 0.0 0.092 12.0 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase PrmA PF06325.13 EXF81098.1 - 0.064 12.6 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) DUF938 PF06080.12 EXF81098.1 - 0.077 12.7 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF938) Methyltransf_16 PF10294.9 EXF81098.1 - 0.11 12.2 0.0 0.18 11.5 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase Methyltransf_4 PF02390.17 EXF81098.1 - 0.15 11.5 0.0 0.26 10.7 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase DREV PF05219.12 EXF81098.1 - 0.17 10.9 0.0 0.25 10.4 0.0 1.2 1 0 0 1 1 1 0 DREV methyltransferase Methyltransf_23 PF13489.6 EXF81099.1 - 1.9e-22 79.8 0.0 2.8e-22 79.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF81099.1 - 4.9e-10 40.0 0.0 1.2e-09 38.7 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF81099.1 - 5.6e-10 39.2 0.0 1.2e-08 34.9 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF81099.1 - 4.1e-08 33.8 0.0 8.7e-08 32.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF81099.1 - 1.3e-07 32.3 0.0 1.9e-06 28.6 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EXF81099.1 - 0.0012 18.4 0.0 0.0019 17.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain CheR PF01739.18 EXF81099.1 - 0.0038 16.7 0.0 0.006 16.1 0.0 1.4 1 0 0 1 1 1 1 CheR methyltransferase, SAM binding domain FtsJ PF01728.19 EXF81099.1 - 0.0045 17.1 0.0 0.0073 16.4 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_2 PF00891.18 EXF81099.1 - 0.0066 15.8 0.0 0.019 14.2 0.0 1.9 2 1 0 2 2 2 1 O-methyltransferase domain PrmA PF06325.13 EXF81099.1 - 0.084 12.3 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_16 PF10294.9 EXF81099.1 - 0.14 11.9 0.0 0.22 11.2 0.0 1.4 1 0 0 1 1 1 0 Lysine methyltransferase NTP_transferase PF00483.23 EXF81100.1 - 0.14 11.7 0.1 0.17 11.5 0.1 1.1 1 0 0 1 1 1 0 Nucleotidyl transferase ABC_tran PF00005.27 EXF81101.1 - 1.8e-39 135.4 0.0 5.2e-19 69.1 0.0 3.2 3 0 0 3 3 3 2 ABC transporter ABC_membrane PF00664.23 EXF81101.1 - 2.6e-30 106.0 25.8 2.1e-26 93.2 16.0 2.5 2 1 0 2 2 2 2 ABC transporter transmembrane region AAA_21 PF13304.6 EXF81101.1 - 1.1e-11 45.1 4.8 0.0031 17.4 0.0 4.3 2 2 1 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EXF81101.1 - 2e-07 30.7 0.0 0.58 9.5 0.0 4.2 3 1 1 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EXF81101.1 - 4.1e-06 26.4 0.1 0.14 11.9 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 EXF81101.1 - 8.8e-05 22.6 0.0 0.26 11.4 0.0 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_25 PF13481.6 EXF81101.1 - 0.00015 21.4 0.0 0.5 9.9 0.0 3.0 2 1 0 2 2 2 2 AAA domain AAA_23 PF13476.6 EXF81101.1 - 0.0002 21.9 0.1 0.39 11.2 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EXF81101.1 - 0.00037 20.9 0.1 1.4 9.3 0.0 2.8 2 0 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 EXF81101.1 - 0.00056 20.2 0.1 2.2 8.6 0.0 3.1 3 0 0 3 3 3 2 AAA domain RsgA_GTPase PF03193.16 EXF81101.1 - 0.00087 19.2 0.0 1.7 8.5 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase AAA_33 PF13671.6 EXF81101.1 - 0.0025 18.0 0.3 0.34 11.1 0.0 3.3 3 0 0 3 3 3 1 AAA domain T2SSE PF00437.20 EXF81101.1 - 0.0064 15.6 0.0 0.49 9.4 0.0 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein DUF87 PF01935.17 EXF81101.1 - 0.0079 16.3 0.1 0.02 15.0 0.1 1.6 1 0 0 1 1 1 1 Helicase HerA, central domain AAA_15 PF13175.6 EXF81101.1 - 0.016 15.0 0.1 2 8.0 0.1 2.2 2 0 0 2 2 2 0 AAA ATPase domain Dynamin_N PF00350.23 EXF81101.1 - 0.016 15.3 1.0 2.5 8.1 0.1 2.5 2 0 0 2 2 2 0 Dynamin family AAA_18 PF13238.6 EXF81101.1 - 0.021 15.4 0.0 11 6.6 0.0 2.8 2 1 0 2 2 2 0 AAA domain ABC_ATPase PF09818.9 EXF81101.1 - 0.036 12.9 1.5 0.56 8.9 0.1 2.8 3 0 0 3 3 3 0 Predicted ATPase of the ABC class AAA_7 PF12775.7 EXF81101.1 - 0.039 13.5 0.0 9.9 5.6 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region FtsK_SpoIIIE PF01580.18 EXF81101.1 - 0.042 13.2 0.0 3.5 6.9 0.0 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family cobW PF02492.19 EXF81101.1 - 0.053 13.1 0.3 3.3 7.2 0.2 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain FYVE PF01363.21 EXF81103.1 - 1.7e-14 53.7 8.2 3e-14 52.9 8.2 1.4 1 0 0 1 1 1 1 FYVE zinc finger zf-AN1 PF01428.16 EXF81103.1 - 0.0035 17.5 5.2 0.0035 17.5 5.2 1.6 1 1 0 1 1 1 1 AN1-like Zinc finger ELO PF01151.18 EXF81104.1 - 7e-83 278.0 10.3 8.7e-83 277.7 10.3 1.1 1 0 0 1 1 1 1 GNS1/SUR4 family GMC_oxred_N PF00732.19 EXF81106.1 - 1.1e-42 146.5 0.8 1.5e-42 146.0 0.8 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EXF81106.1 - 3.2e-27 95.8 0.5 3.1e-26 92.6 0.0 2.5 2 0 0 2 2 2 1 GMC oxidoreductase FAD_binding_3 PF01494.19 EXF81106.1 - 4.6e-06 26.1 0.1 7.3e-06 25.5 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain FAD_binding_2 PF00890.24 EXF81106.1 - 8.6e-06 25.1 4.0 2.2e-05 23.7 4.0 1.7 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EXF81106.1 - 1.1e-05 24.8 0.2 3.1e-05 23.4 0.2 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EXF81106.1 - 2.7e-05 23.6 0.5 0.0013 18.0 0.6 2.2 2 0 0 2 2 2 1 Thi4 family NAD_binding_8 PF13450.6 EXF81106.1 - 0.00029 21.0 3.4 0.00036 20.7 1.1 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 EXF81106.1 - 0.0041 16.5 1.8 0.0068 15.8 1.8 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 EXF81106.1 - 0.0059 15.4 0.6 0.009 14.8 0.2 1.5 2 0 0 2 2 2 1 HI0933-like protein DAO PF01266.24 EXF81106.1 - 0.01 15.4 4.9 0.14 11.7 4.9 2.2 1 1 0 1 1 1 0 FAD dependent oxidoreductase UDPG_MGDP_dh_N PF03721.14 EXF81106.1 - 0.025 14.2 1.4 0.041 13.4 1.4 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain AlaDh_PNT_C PF01262.21 EXF81106.1 - 0.043 13.1 0.0 0.076 12.3 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.22 EXF81106.1 - 0.048 12.7 0.4 0.1 11.7 0.2 1.6 2 0 0 2 2 2 0 Glucose inhibited division protein A GDI PF00996.18 EXF81106.1 - 0.049 12.1 0.0 0.075 11.5 0.0 1.1 1 0 0 1 1 1 0 GDP dissociation inhibitor Pyr_redox PF00070.27 EXF81106.1 - 0.062 13.9 0.2 0.14 12.8 0.2 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 EXF81106.1 - 0.064 13.1 0.1 0.14 12.0 0.1 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ThiF PF00899.21 EXF81106.1 - 0.14 11.5 0.1 0.28 10.5 0.1 1.4 1 0 0 1 1 1 0 ThiF family MoaC PF01967.21 EXF81107.1 - 1.3e-51 174.3 2.2 2.6e-51 173.3 2.2 1.6 1 0 0 1 1 1 1 MoaC family Mob_synth_C PF06463.13 EXF81107.1 - 2.4e-37 127.7 0.0 2.8e-36 124.3 0.0 2.2 1 1 1 2 2 2 1 Molybdenum Cofactor Synthesis C Radical_SAM PF04055.21 EXF81107.1 - 2.3e-25 89.9 0.0 4.2e-25 89.1 0.0 1.4 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_12 PF13353.6 EXF81107.1 - 0.00042 20.6 0.0 0.0011 19.2 0.0 1.7 1 0 0 1 1 1 1 4Fe-4S single cluster domain eIF_4EBP PF05456.11 EXF81107.1 - 0.83 9.6 6.1 0.13 12.2 0.9 2.3 2 1 0 2 2 2 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) PD40 PF07676.12 EXF81108.1 - 0.023 14.7 0.3 6.4 6.8 0.0 4.2 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat Gmad1 PF10647.9 EXF81108.1 - 0.048 13.4 3.6 0.21 11.3 0.4 3.3 3 1 0 3 3 3 0 Lipoprotein LpqB beta-propeller domain WD40 PF00400.32 EXF81108.1 - 0.2 12.6 12.7 45 5.1 0.1 6.3 5 1 1 6 6 6 0 WD domain, G-beta repeat HEAT_2 PF13646.6 EXF81110.1 - 1e-11 45.1 4.2 0.026 14.9 0.0 7.5 7 1 1 8 8 8 3 HEAT repeats Vac14_Fab1_bd PF12755.7 EXF81110.1 - 1.5e-06 28.7 0.0 0.077 13.6 0.0 4.7 4 0 0 4 4 4 2 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 EXF81110.1 - 7.6e-05 22.8 0.1 0.38 10.8 0.0 4.5 4 0 0 4 4 4 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 EXF81110.1 - 0.00039 20.5 16.2 1 9.8 0.0 8.4 9 0 0 9 9 9 2 HEAT repeat HEAT_EZ PF13513.6 EXF81110.1 - 0.00045 20.7 12.3 5.4 7.6 0.1 7.5 7 1 1 8 8 8 2 HEAT-like repeat UNC45-central PF11701.8 EXF81110.1 - 0.018 15.0 0.5 1.3 9.0 0.0 4.2 4 0 0 4 4 4 0 Myosin-binding striated muscle assembly central CLASP_N PF12348.8 EXF81110.1 - 0.023 14.3 4.2 6 6.4 0.0 4.1 5 0 0 5 5 5 0 CLASP N terminal V-ATPase_H_C PF11698.8 EXF81110.1 - 0.027 14.6 0.1 2.1 8.5 0.0 3.9 3 0 0 3 3 3 0 V-ATPase subunit H Transcrip_reg PF01709.20 EXF81111.1 - 3.5e-66 223.0 0.1 4.1e-66 222.8 0.1 1.0 1 0 0 1 1 1 1 Transcriptional regulator Pet100 PF09803.9 EXF81112.1 - 1.5e-10 41.4 2.4 3.2e-10 40.4 2.4 1.5 1 1 0 1 1 1 1 Pet100 Rbsn PF11464.8 EXF81112.1 - 0.054 13.2 0.3 0.089 12.5 0.3 1.4 1 0 0 1 1 1 0 Rabenosyn Rab binding domain Dynamin_N PF00350.23 EXF81114.1 - 2.4e-13 50.5 5.3 6.8e-13 49.0 0.0 3.0 3 0 0 3 3 3 1 Dynamin family MMR_HSR1 PF01926.23 EXF81114.1 - 4.9e-05 23.4 1.2 0.0011 19.1 0.0 3.5 3 1 0 3 3 3 1 50S ribosome-binding GTPase ABC_tran PF00005.27 EXF81114.1 - 0.00048 20.7 0.1 0.0022 18.5 0.0 2.2 2 0 0 2 2 2 1 ABC transporter KAP_NTPase PF07693.14 EXF81114.1 - 0.0029 16.9 0.0 0.047 12.9 0.0 2.4 2 0 0 2 2 2 1 KAP family P-loop domain RsgA_GTPase PF03193.16 EXF81114.1 - 0.0059 16.5 0.0 0.022 14.7 0.0 2.0 1 0 0 1 1 1 1 RsgA GTPase IIGP PF05049.13 EXF81114.1 - 0.027 13.5 0.0 0.082 11.9 0.0 1.8 2 0 0 2 2 2 0 Interferon-inducible GTPase (IIGP) NB-ARC PF00931.22 EXF81114.1 - 0.055 12.6 0.0 0.14 11.4 0.0 1.7 1 0 0 1 1 1 0 NB-ARC domain T2SSE PF00437.20 EXF81114.1 - 0.056 12.5 0.0 0.11 11.6 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein DUF1664 PF07889.12 EXF81114.1 - 0.063 13.3 0.7 6.2 6.9 0.7 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) AAA_29 PF13555.6 EXF81114.1 - 0.072 12.8 0.0 0.16 11.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Goodbye PF17109.5 EXF81114.1 - 0.09 13.2 1.5 0.38 11.2 1.5 2.1 1 0 0 1 1 1 0 fungal STAND N-terminal Goodbye domain AAA_16 PF13191.6 EXF81114.1 - 0.099 13.0 2.8 0.68 10.3 0.0 3.6 3 2 1 4 4 4 0 AAA ATPase domain SIMPL PF04402.14 EXF81114.1 - 0.3 11.5 0.1 0.3 11.5 0.1 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF541) DUF87 PF01935.17 EXF81114.1 - 0.35 10.9 3.9 1.3 9.1 0.0 3.1 3 0 0 3 3 3 0 Helicase HerA, central domain NUDIX_2 PF13869.6 EXF81115.1 - 1.5e-80 269.2 0.0 1.8e-80 269.0 0.0 1.1 1 0 0 1 1 1 1 Nucleotide hydrolase UPF0047 PF01894.17 EXF81116.1 - 3.5e-37 127.1 0.0 4.5e-37 126.7 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein family UPF0047 zf-CHCC PF10276.9 EXF81117.1 - 2.3e-15 56.3 0.4 3.5e-15 55.8 0.4 1.3 1 0 0 1 1 1 1 Zinc-finger domain Peptidase_M16_M PF16187.5 EXF81118.1 - 1.2e-95 320.0 0.5 2.1e-95 319.2 0.5 1.4 1 0 0 1 1 1 1 Middle or third domain of peptidase_M16 UCH PF00443.29 EXF81118.1 - 1.4e-66 224.7 0.0 3.3e-66 223.4 0.0 1.7 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Peptidase_M16_C PF05193.21 EXF81118.1 - 2.7e-34 118.8 0.0 2.2e-18 67.0 0.0 2.8 2 0 0 2 2 2 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EXF81118.1 - 6.3e-31 107.4 0.2 6.3e-31 107.4 0.2 2.5 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) UCH_1 PF13423.6 EXF81118.1 - 1.5e-09 37.9 0.0 0.00023 20.8 0.0 3.4 3 1 0 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.12 EXF81118.1 - 3.4e-08 34.0 0.0 1e-07 32.5 0.0 1.9 1 0 0 1 1 1 1 DUSP domain Roughex PF06020.11 EXF81118.1 - 0.18 10.9 4.3 0.48 9.5 4.3 1.7 1 0 0 1 1 1 0 Drosophila roughex protein Adaptin_binding PF10199.9 EXF81118.1 - 0.94 10.1 7.5 0.13 12.9 0.8 2.9 2 0 0 2 2 2 0 Alpha and gamma adaptin binding protein p34 RAM PF15320.6 EXF81118.1 - 5.9 7.6 8.4 32 5.2 8.4 2.4 1 0 0 1 1 1 0 mRNA cap methylation, RNMT-activating mini protein MPP6 PF10175.9 EXF81119.1 - 2.6e-08 34.4 13.3 0.00046 20.7 2.6 3.0 2 1 1 3 3 3 2 M-phase phosphoprotein 6 zf-CCHC PF00098.23 EXF81119.1 - 2.5e-06 27.3 4.6 3.8e-06 26.7 4.6 1.3 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_2 PF13696.6 EXF81119.1 - 0.00028 20.6 1.8 0.00048 19.9 1.8 1.4 1 0 0 1 1 1 1 Zinc knuckle TFIIA PF03153.13 EXF81119.1 - 0.6 10.1 14.9 0.21 11.6 12.5 1.4 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Menin PF05053.13 EXF81119.1 - 2.2 6.5 7.4 2.5 6.3 7.4 1.3 1 0 0 1 1 1 0 Menin DUF4692 PF15763.5 EXF81119.1 - 2.7 8.4 10.5 1.6 9.2 7.8 2.0 2 0 0 2 2 2 0 Regulator of human erythroid cell expansion (RHEX) eIF-3c_N PF05470.12 EXF81119.1 - 3.8 5.7 8.9 5 5.3 8.9 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus DNA_pol_phi PF04931.13 EXF81119.1 - 5.9 4.9 9.2 7.5 4.5 9.2 1.1 1 0 0 1 1 1 0 DNA polymerase phi NPR3 PF03666.13 EXF81119.1 - 7.7 5.2 7.8 11 4.7 7.8 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DAO PF01266.24 EXF81120.1 - 6.1e-43 147.8 0.7 7.3e-43 147.5 0.7 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EXF81120.1 - 2.8e-05 24.3 1.0 8e-05 22.8 0.7 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain MCRA PF06100.11 EXF81120.1 - 0.0085 14.9 0.2 0.014 14.2 0.2 1.3 1 0 0 1 1 1 1 MCRA family Pyr_redox_2 PF07992.14 EXF81120.1 - 0.013 14.8 0.0 0.73 9.0 0.1 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EXF81120.1 - 1.8 7.6 5.0 2.3 7.2 3.1 1.9 2 0 0 2 2 2 0 FAD binding domain MFS_1 PF07690.16 EXF81121.1 - 9e-30 103.8 29.8 2.3e-25 89.3 7.2 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily TPR_1 PF00515.28 EXF81122.1 - 6e-54 177.8 31.6 6.4e-08 32.1 0.0 10.4 11 1 0 11 11 10 8 Tetratricopeptide repeat TPR_2 PF07719.17 EXF81122.1 - 9.4e-48 156.5 26.3 1.7e-06 27.7 0.0 10.3 11 0 0 11 11 10 9 Tetratricopeptide repeat TPR_8 PF13181.6 EXF81122.1 - 1.9e-39 130.5 24.7 3.2e-07 30.0 0.0 10.6 10 1 0 10 10 10 9 Tetratricopeptide repeat TPR_16 PF13432.6 EXF81122.1 - 2.1e-29 101.9 14.5 1.2e-07 32.2 0.0 6.5 3 2 2 6 6 6 6 Tetratricopeptide repeat TPR_14 PF13428.6 EXF81122.1 - 4.7e-28 95.5 17.1 4.9e-05 23.8 0.1 9.0 3 2 7 10 10 10 7 Tetratricopeptide repeat TPR_17 PF13431.6 EXF81122.1 - 9.4e-27 91.4 15.8 0.0024 18.1 0.0 10.2 11 0 0 11 11 10 6 Tetratricopeptide repeat TPR_11 PF13414.6 EXF81122.1 - 4.1e-25 87.2 28.7 3.7e-06 26.5 0.2 9.3 4 2 5 9 9 9 5 TPR repeat TPR_19 PF14559.6 EXF81122.1 - 7.2e-23 80.9 20.3 0.00017 22.0 0.1 6.9 4 2 3 7 7 7 6 Tetratricopeptide repeat TPR_12 PF13424.6 EXF81122.1 - 4.9e-22 78.0 24.6 4.7e-05 23.6 0.9 7.5 4 2 2 6 6 6 5 Tetratricopeptide repeat TPR_6 PF13174.6 EXF81122.1 - 1.3e-21 75.7 18.2 0.0014 19.1 0.0 9.5 10 0 0 10 10 10 5 Tetratricopeptide repeat TPR_7 PF13176.6 EXF81122.1 - 2.1e-17 61.8 16.9 0.01 15.8 0.1 9.5 8 1 1 9 9 9 3 Tetratricopeptide repeat TPR_9 PF13371.6 EXF81122.1 - 1.1e-15 57.6 16.9 0.0011 19.1 0.1 6.1 2 2 4 7 7 7 6 Tetratricopeptide repeat ANAPC3 PF12895.7 EXF81122.1 - 1.1e-14 54.4 12.2 1.5e-08 34.7 1.1 3.6 3 1 1 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_15 PF13429.6 EXF81122.1 - 2.2e-11 43.5 12.0 0.0016 17.7 1.2 5.3 1 1 3 5 5 5 4 Tetratricopeptide repeat TPR_21 PF09976.9 EXF81122.1 - 2.6e-07 30.5 9.6 0.019 14.7 0.0 5.1 4 2 1 5 5 5 2 Tetratricopeptide repeat-like domain Fis1_TPR_C PF14853.6 EXF81122.1 - 0.00028 20.9 0.6 32 4.7 0.0 5.3 5 0 0 5 5 5 0 Fis1 C-terminal tetratricopeptide repeat TPR_20 PF14561.6 EXF81122.1 - 0.0012 19.1 6.9 0.54 10.6 0.4 3.9 3 1 1 4 4 3 2 Tetratricopeptide repeat BTAD PF03704.17 EXF81122.1 - 0.011 16.1 0.4 0.011 16.1 0.4 3.9 3 1 0 4 4 3 0 Bacterial transcriptional activator domain TPR_10 PF13374.6 EXF81122.1 - 0.012 15.4 21.3 4 7.4 0.0 7.7 8 0 0 8 8 8 0 Tetratricopeptide repeat DUF2225 PF09986.9 EXF81122.1 - 0.013 15.2 1.7 1.6 8.4 0.1 3.3 1 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) RPN7 PF10602.9 EXF81122.1 - 0.39 10.4 6.1 1.4 8.6 0.2 4.1 5 1 1 6 6 6 0 26S proteasome subunit RPN7 Cohesin_load PF10345.9 EXF81122.1 - 0.52 8.7 2.5 18 3.6 0.2 2.8 2 1 1 3 3 3 0 Cohesin loading factor SNAP PF14938.6 EXF81122.1 - 0.76 9.1 17.3 11 5.3 1.9 4.8 1 1 3 4 4 4 0 Soluble NSF attachment protein, SNAP Ribosomal_L3 PF00297.22 EXF81123.1 - 4.4e-180 598.5 9.7 4.9e-180 598.3 9.7 1.0 1 0 0 1 1 1 1 Ribosomal protein L3 DUF1639 PF07797.14 EXF81123.1 - 0.23 11.4 1.0 0.79 9.8 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1639) Chorismate_bind PF00425.18 EXF81125.1 - 3.6e-90 302.0 0.0 1.6e-89 299.9 0.0 1.9 2 0 0 2 2 2 1 chorismate binding enzyme Anth_synt_I_N PF04715.13 EXF81125.1 - 6.8e-26 91.2 0.0 2.7e-21 76.3 0.0 3.8 3 1 0 3 3 3 2 Anthranilate synthase component I, N terminal region Mycoplasma_p37 PF06646.11 EXF81125.1 - 0.2 10.8 0.2 0.42 9.8 0.0 1.6 2 0 0 2 2 2 0 High affinity transport system protein p37 RGS PF00615.19 EXF81126.1 - 0.0039 17.5 0.0 0.007 16.6 0.0 1.6 1 1 0 1 1 1 1 Regulator of G protein signaling domain DUF2065 PF09838.9 EXF81126.1 - 0.0069 16.4 1.7 0.029 14.4 0.1 2.5 2 0 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2065) TMEM43 PF07787.12 EXF81126.1 - 0.037 13.4 0.0 0.064 12.6 0.0 1.3 1 0 0 1 1 1 0 Transmembrane protein 43 DUF2157 PF09925.9 EXF81126.1 - 0.055 13.3 0.5 0.16 11.8 0.1 1.8 2 0 0 2 2 2 0 Predicted membrane protein (DUF2157) NAD_binding_2 PF03446.15 EXF81127.1 - 8.1e-19 68.3 0.0 1.1e-18 67.9 0.0 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Shikimate_DH PF01488.20 EXF81127.1 - 0.042 13.9 0.0 0.095 12.8 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Glyco_hydro_72 PF03198.14 EXF81129.1 - 3.1e-95 319.1 0.1 4.2e-95 318.6 0.1 1.0 1 0 0 1 1 1 1 Glucanosyltransferase Cellulase PF00150.18 EXF81129.1 - 0.0011 18.5 0.4 0.0053 16.2 0.4 2.0 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_2_C PF02836.17 EXF81129.1 - 0.0033 16.6 0.6 0.0065 15.6 0.1 1.6 2 0 0 2 2 2 1 Glycosyl hydrolases family 2, TIM barrel domain Pkinase PF00069.25 EXF81130.1 - 9.2e-11 41.6 0.0 1.1e-06 28.3 0.0 2.6 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EXF81130.1 - 8.8e-07 28.5 0.0 2.7e-06 26.8 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 EXF81130.1 - 0.0051 16.2 0.0 0.0093 15.3 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Queuosine_synth PF02547.15 EXF81130.1 - 0.15 11.1 0.0 0.31 10.1 0.0 1.5 2 0 0 2 2 2 0 Queuosine biosynthesis protein Sugar_tr PF00083.24 EXF81131.1 - 2.7e-107 359.4 23.3 3.3e-107 359.2 23.3 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF81131.1 - 1.1e-19 70.6 29.9 1.1e-19 70.6 29.9 2.3 1 1 1 2 2 2 1 Major Facilitator Superfamily DUF1324 PF07038.11 EXF81131.1 - 0.027 14.7 0.1 0.19 12.0 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1324) DUF4410 PF14366.6 EXF81131.1 - 0.11 12.4 0.0 0.24 11.3 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4410) MFS_1 PF07690.16 EXF81132.1 - 1.9e-39 135.6 39.3 1.9e-39 135.6 39.3 2.0 1 1 2 3 3 3 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF81132.1 - 1.3e-12 47.3 11.8 1.3e-12 47.3 11.8 2.4 2 2 0 2 2 2 1 Sugar (and other) transporter GFA PF04828.14 EXF81133.1 - 5e-06 26.8 0.2 5e-06 26.8 0.2 1.6 2 0 0 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme DUF2318 PF10080.9 EXF81133.1 - 0.085 13.0 1.9 1.4 9.0 0.1 2.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2318) Minor_capsid_3 PF12691.7 EXF81133.1 - 0.11 12.9 0.0 0.18 12.2 0.0 1.3 1 0 0 1 1 1 0 Minor capsid protein from bacteriophage DUF678 PF05077.12 EXF81133.1 - 0.13 12.4 2.9 0.4 10.8 2.7 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF678) Auto_anti-p27 PF06677.12 EXF81133.1 - 0.82 9.9 8.3 2 8.7 0.1 3.0 2 1 1 3 3 3 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) adh_short PF00106.25 EXF81134.1 - 4.2e-39 134.0 0.3 6.3e-39 133.5 0.3 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF81134.1 - 6.4e-32 111.0 0.1 1.2e-31 110.0 0.0 1.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF81134.1 - 8.3e-10 38.9 3.2 7.8e-09 35.7 3.2 2.0 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 EXF81134.1 - 0.012 15.1 0.1 0.018 14.5 0.1 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family WD40 PF00400.32 EXF81135.1 - 2.9e-33 113.3 9.3 4.6e-08 33.6 0.0 6.4 6 0 0 6 6 6 6 WD domain, G-beta repeat Sof1 PF04158.14 EXF81135.1 - 1.2e-30 105.6 14.6 2.3e-30 104.7 14.6 1.5 1 0 0 1 1 1 1 Sof1-like domain ANAPC4_WD40 PF12894.7 EXF81135.1 - 4.4e-11 42.9 0.1 0.00024 21.3 0.0 5.0 2 1 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Frtz PF11768.8 EXF81135.1 - 0.0014 17.0 0.0 0.034 12.5 0.0 2.4 1 1 0 2 2 2 1 WD repeat-containing and planar cell polarity effector protein Fritz Ge1_WD40 PF16529.5 EXF81135.1 - 0.0056 15.7 0.1 5.3 5.9 0.0 3.2 2 2 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 EXF81135.1 - 0.019 13.5 0.2 6.6 5.1 0.0 3.0 1 1 1 3 3 3 0 Cytochrome D1 heme domain RPN6_N PF18055.1 EXF81136.1 - 1.9e-46 157.2 2.2 1.9e-46 157.2 2.2 2.7 3 1 0 3 3 3 1 26S proteasome regulatory subunit RPN6 N-terminal domain PCI PF01399.27 EXF81136.1 - 3.3e-22 79.0 2.1 4.2e-22 78.6 0.4 2.1 3 0 0 3 3 2 1 PCI domain RPN6_C_helix PF18503.1 EXF81136.1 - 1.2e-07 31.3 0.9 2.9e-07 30.1 0.9 1.8 1 0 0 1 1 1 1 26S proteasome subunit RPN6 C-terminal helix domain DDRGK PF09756.9 EXF81136.1 - 6.6e-05 22.6 0.8 6.6e-05 22.6 0.8 2.0 2 0 0 2 2 2 1 DDRGK domain TPR_7 PF13176.6 EXF81136.1 - 0.0002 21.1 3.2 0.45 10.6 0.5 4.4 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_MalT PF17874.1 EXF81136.1 - 0.00033 20.1 2.2 0.00033 20.1 2.2 2.9 2 2 0 2 2 2 1 MalT-like TPR region TPR_12 PF13424.6 EXF81136.1 - 0.00089 19.5 20.0 0.022 15.1 1.7 5.7 4 1 2 6 6 6 1 Tetratricopeptide repeat TPR_1 PF00515.28 EXF81136.1 - 0.0029 17.4 1.4 2.1 8.3 0.1 4.8 5 0 0 5 5 5 1 Tetratricopeptide repeat INT_SG_DDX_CT_C PF15300.6 EXF81136.1 - 0.023 14.5 0.0 0.053 13.3 0.0 1.6 1 0 0 1 1 1 0 INTS6/SAGE1/DDX26B/CT45 C-terminus TPR_8 PF13181.6 EXF81136.1 - 0.025 14.8 5.2 11 6.5 0.1 5.3 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_10 PF13374.6 EXF81136.1 - 0.032 14.1 0.7 13 5.8 0.0 4.5 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_6 PF13174.6 EXF81136.1 - 0.034 14.8 4.1 86 4.1 0.1 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat HTH_Crp_2 PF13545.6 EXF81136.1 - 0.058 13.4 0.1 0.42 10.6 0.0 2.4 2 0 0 2 2 2 0 Crp-like helix-turn-helix domain DUF4456 PF14644.6 EXF81136.1 - 0.097 12.3 5.4 7.6 6.2 3.4 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4456) TPR_4 PF07721.14 EXF81136.1 - 0.13 12.9 0.2 1.1 10.1 0.0 2.8 2 0 0 2 2 1 0 Tetratricopeptide repeat TPR_2 PF07719.17 EXF81136.1 - 0.44 10.8 8.5 30 5.0 0.0 5.1 5 1 1 6 6 6 0 Tetratricopeptide repeat DUF2564 PF10819.8 EXF81136.1 - 1.9 8.9 5.5 4.2 7.8 1.7 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2564) TPR_14 PF13428.6 EXF81136.1 - 2.2 9.3 10.7 43 5.3 0.1 5.2 5 1 1 6 6 5 0 Tetratricopeptide repeat TPR_11 PF13414.6 EXF81136.1 - 2.3 8.0 6.6 9.7 6.0 0.2 3.8 4 0 0 4 4 4 0 TPR repeat Mito_carr PF00153.27 EXF81138.1 - 3.2e-51 171.2 6.1 6.1e-17 61.3 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein UcrQ PF02939.16 EXF81138.1 - 0.077 12.9 0.1 0.25 11.3 0.1 1.9 1 0 0 1 1 1 0 UcrQ family Mak10 PF04112.13 EXF81139.1 - 1.4e-64 216.7 0.1 6.9e-64 214.4 0.0 2.2 3 0 0 3 3 3 1 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase Alpha-E PF04168.12 EXF81139.1 - 0.064 13.0 0.1 0.15 11.8 0.0 1.6 2 0 0 2 2 2 0 A predicted alpha-helical domain with a conserved ER motif. ATP-synt_Eps PF04627.13 EXF81140.1 - 9.9e-24 83.1 0.9 1.3e-23 82.7 0.9 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase epsilon chain PMBR PF09373.10 EXF81140.1 - 0.094 12.9 0.1 0.15 12.3 0.1 1.3 1 0 0 1 1 1 0 Pseudomurein-binding repeat FAD_binding_3 PF01494.19 EXF81141.1 - 3.2e-20 72.7 0.1 6.9e-09 35.4 0.0 3.0 2 1 0 2 2 2 2 FAD binding domain DAO PF01266.24 EXF81141.1 - 8.1e-05 22.4 0.1 0.09 12.3 0.1 2.3 1 1 0 2 2 2 2 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 EXF81141.1 - 0.00013 21.2 0.1 0.029 13.4 0.1 2.2 2 0 0 2 2 2 2 Lycopene cyclase protein SE PF08491.10 EXF81141.1 - 0.00027 20.1 0.0 0.0047 16.0 0.0 2.0 2 0 0 2 2 2 1 Squalene epoxidase NAD_binding_8 PF13450.6 EXF81141.1 - 0.00029 21.0 0.1 0.00082 19.6 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain ApbA PF02558.16 EXF81141.1 - 0.075 12.7 0.0 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Pyr_redox_2 PF07992.14 EXF81141.1 - 0.088 12.0 0.0 0.18 11.0 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase AIP3 PF03915.13 EXF81142.1 - 2e-158 527.8 7.1 3.4e-158 527.0 7.1 1.4 1 0 0 1 1 1 1 Actin interacting protein 3 RasGAP_C PF03836.15 EXF81142.1 - 0.047 13.8 2.3 0.77 9.9 0.2 3.5 4 0 0 4 4 4 0 RasGAP C-terminus Lectin_N PF03954.14 EXF81142.1 - 0.058 13.1 0.8 0.33 10.7 0.1 2.6 2 0 0 2 2 2 0 Hepatic lectin, N-terminal domain NPV_P10 PF05531.12 EXF81142.1 - 0.36 11.3 7.5 0.22 12.0 0.8 3.5 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein Baculo_PEP_C PF04513.12 EXF81142.1 - 1.4 9.0 7.4 2 8.4 0.0 3.5 4 0 0 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus BNIP3 PF06553.12 EXF81142.1 - 5.5 6.6 9.0 0.27 10.9 2.8 2.1 2 0 0 2 2 2 0 BNIP3 Fib_alpha PF08702.10 EXF81142.1 - 9.2 6.4 8.5 36 4.5 0.2 4.0 2 1 0 3 3 3 0 Fibrinogen alpha/beta chain family Pro_isomerase PF00160.21 EXF81143.1 - 1e-43 149.3 0.0 1.2e-43 149.2 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD MFS_1 PF07690.16 EXF81144.1 - 3.1e-29 102.0 27.5 3.1e-29 102.0 27.5 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily OATP PF03137.20 EXF81144.1 - 4.8 5.3 11.1 25 3.0 9.0 2.9 3 1 0 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family HSF_DNA-bind PF00447.17 EXF81145.1 - 1.8e-28 99.0 0.4 4e-28 97.9 0.4 1.6 1 0 0 1 1 1 1 HSF-type DNA-binding Ets PF00178.22 EXF81145.1 - 0.06 13.8 0.1 0.14 12.6 0.1 1.6 1 0 0 1 1 1 0 Ets-domain Pro_isomerase PF00160.21 EXF81146.1 - 6.9e-41 140.1 0.0 1.5e-40 139.0 0.0 1.6 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD DS PF01916.17 EXF81148.1 - 5.7e-130 432.7 0.0 6.5e-130 432.5 0.0 1.0 1 0 0 1 1 1 1 Deoxyhypusine synthase Myb_DNA-binding PF00249.31 EXF81149.1 - 1.2e-07 31.8 0.0 0.0009 19.4 0.0 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Arrestin_C PF02752.22 EXF81150.1 - 2.1e-14 54.1 0.5 1.3e-13 51.5 0.1 2.3 2 1 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain adh_short PF00106.25 EXF81151.1 - 1.1e-21 77.2 0.0 4.4e-17 62.2 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EXF81151.1 - 2.5e-15 56.7 0.0 2.2e-14 53.6 0.0 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF81151.1 - 0.0021 18.0 0.0 0.0031 17.4 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EXF81151.1 - 0.0027 17.2 0.0 0.0038 16.7 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family ORC6 PF05460.13 EXF81152.1 - 1.7e-33 116.4 0.0 2.4e-33 115.9 0.0 1.3 1 1 0 1 1 1 1 Origin recognition complex subunit 6 (ORC6) EF-hand_6 PF13405.6 EXF81153.1 - 7.9e-06 25.4 0.3 0.055 13.4 0.1 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 EXF81153.1 - 0.00067 19.0 0.1 0.0048 16.4 0.0 2.2 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 EXF81153.1 - 0.0021 18.5 0.5 0.0044 17.4 0.5 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 EXF81153.1 - 0.0023 17.3 0.1 0.0099 15.3 0.0 2.0 2 0 0 2 2 2 1 EF hand Met_10 PF02475.16 EXF81154.1 - 5.6e-06 26.2 0.0 5.8e-05 22.9 0.0 2.1 1 1 0 1 1 1 1 Met-10+ like-protein Rpr2 PF04032.16 EXF81155.1 - 1.1e-14 54.4 1.1 1.1e-14 54.4 1.1 1.9 2 1 0 2 2 2 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain Nudix_N_2 PF14803.6 EXF81155.1 - 0.14 12.1 1.6 0.42 10.6 0.3 2.2 2 0 0 2 2 2 0 Nudix N-terminal zinc_ribbon_12 PF11331.8 EXF81155.1 - 2.8 7.8 5.9 8.9 6.2 0.1 2.8 3 0 0 3 3 3 0 Probable zinc-ribbon domain zf-ZPR1 PF03367.13 EXF81156.1 - 3e-112 371.7 0.0 2.9e-56 189.7 0.0 2.3 2 0 0 2 2 2 2 ZPR1 zinc-finger domain zf-RRPl_C4 PF17026.5 EXF81156.1 - 0.53 10.4 2.0 25 5.1 0.1 2.3 2 0 0 2 2 2 0 Putative ribonucleoprotein zinc-finger pf C4 type Pirin PF02678.16 EXF81159.1 - 1.5e-24 86.0 0.9 4e-24 84.7 0.9 1.7 1 1 0 1 1 1 1 Pirin Cupin_2 PF07883.11 EXF81159.1 - 0.00029 20.5 5.6 0.032 13.9 1.1 3.3 3 1 0 3 3 3 2 Cupin domain MelC1 PF06236.11 EXF81159.1 - 0.043 13.9 0.6 0.1 12.7 0.1 2.0 2 1 0 2 2 2 0 Tyrosinase co-factor MelC1 Yae1_N PF09811.9 EXF81160.1 - 1.9e-13 49.8 1.4 3.3e-13 49.1 1.4 1.4 1 0 0 1 1 1 1 Essential protein Yae1, N terminal CENP-O PF09496.10 EXF81162.1 - 8.8e-73 244.8 2.1 2.2e-72 243.5 0.0 1.9 2 0 0 2 2 2 1 Cenp-O kinetochore centromere component Phage_GP20 PF06810.11 EXF81162.1 - 0.024 14.5 3.8 0.05 13.4 3.8 1.5 1 0 0 1 1 1 0 Phage minor structural protein GP20 Acatn PF13000.7 EXF81163.1 - 1.8e-166 554.9 16.5 1.1e-84 285.0 7.3 3.2 1 1 2 3 3 3 3 Acetyl-coenzyme A transporter 1 DFP PF04127.15 EXF81164.1 - 1e-14 54.8 0.0 5.6e-06 26.3 0.0 3.3 2 1 0 3 3 3 3 DNA / pantothenate metabolism flavoprotein MFS_1 PF07690.16 EXF81165.1 - 1.1e-40 139.6 76.7 2.2e-37 128.8 49.8 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF81165.1 - 7e-11 41.6 44.3 3.1e-06 26.3 20.4 2.5 2 1 0 2 2 2 2 Sugar (and other) transporter Epiglycanin_C PF14654.6 EXF81165.1 - 0.74 9.9 4.9 11 6.1 0.1 3.0 3 0 0 3 3 3 0 Mucin, catalytic, TM and cytoplasmic tail region GMC_oxred_N PF00732.19 EXF81166.1 - 9.3e-56 189.4 0.0 1.2e-55 188.9 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EXF81166.1 - 5.5e-31 108.0 0.0 8.2e-31 107.5 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase Lycopene_cycl PF05834.12 EXF81166.1 - 0.00099 18.3 0.0 0.0049 16.0 0.0 2.0 3 0 0 3 3 3 1 Lycopene cyclase protein Pyr_redox_2 PF07992.14 EXF81166.1 - 0.0095 15.2 0.0 0.65 9.2 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EXF81166.1 - 0.028 14.6 0.2 0.089 13.0 0.0 1.9 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EXF81166.1 - 0.088 11.9 0.0 2.5 7.1 0.0 2.2 2 0 0 2 2 2 0 FAD binding domain DAO PF01266.24 EXF81166.1 - 0.18 11.3 1.2 1.9 8.0 1.2 2.2 1 1 0 1 1 1 0 FAD dependent oxidoreductase TfuA PF07812.12 EXF81167.1 - 0.088 12.5 3.2 0.091 12.5 1.5 1.8 2 0 0 2 2 2 0 TfuA-like protein MFS_1 PF07690.16 EXF81169.1 - 4.6e-22 78.4 21.1 4.6e-22 78.4 21.1 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF81169.1 - 8.1e-07 28.2 32.9 0.00023 20.2 32.9 3.2 1 1 0 1 1 1 1 Sugar (and other) transporter DUF2721 PF11026.8 EXF81169.1 - 1.1 9.1 9.5 3.6 7.5 0.0 4.4 2 1 2 5 5 5 0 Protein of unknown function (DUF2721) Phage_holin_7_1 PF16081.5 EXF81169.1 - 1.3 9.3 7.0 1.1 9.4 0.2 2.4 2 0 0 2 2 2 0 Mycobacterial 2 TMS Phage Holin (M2 Hol) Family DUF5336 PF17270.2 EXF81169.1 - 7.7 6.1 11.0 0.62 9.7 0.1 3.5 4 0 0 4 4 4 0 Family of unknown function (DUF5336) Lyase_1 PF00206.20 EXF81170.1 - 2.4e-24 86.3 0.2 5.2e-24 85.2 0.2 1.5 1 0 0 1 1 1 1 Lyase ASL_C2 PF14698.6 EXF81170.1 - 1.7e-10 41.5 0.0 4.7e-10 40.1 0.0 1.8 1 0 0 1 1 1 1 Argininosuccinate lyase C-terminal Pup_ligase PF03136.15 EXF81170.1 - 0.037 13.1 0.0 0.077 12.0 0.0 1.5 2 0 0 2 2 2 0 Pup-ligase protein Abhydrolase_3 PF07859.13 EXF81171.1 - 1.9e-05 24.6 0.0 0.00023 21.1 0.0 2.2 2 0 0 2 2 2 1 alpha/beta hydrolase fold DUF915 PF06028.11 EXF81171.1 - 7.8e-05 22.1 0.0 0.00013 21.4 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF915) Lipase_3 PF01764.25 EXF81171.1 - 0.00032 20.6 0.0 0.0029 17.5 0.0 2.2 1 1 0 1 1 1 1 Lipase (class 3) Hydrolase_4 PF12146.8 EXF81171.1 - 0.015 14.6 0.0 0.03 13.6 0.0 1.5 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Thioesterase PF00975.20 EXF81171.1 - 0.025 14.7 0.0 0.043 13.9 0.0 1.4 1 0 0 1 1 1 0 Thioesterase domain bPH_6 PF10756.9 EXF81171.1 - 0.11 12.6 0.1 34 4.6 0.0 3.0 3 1 1 4 4 4 0 Bacterial PH domain DUF2974 PF11187.8 EXF81171.1 - 0.18 11.4 0.0 0.29 10.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) TPR_12 PF13424.6 EXF81172.1 - 1.2e-29 102.4 16.7 2e-07 31.2 0.9 8.3 6 2 2 8 8 8 5 Tetratricopeptide repeat TPR_10 PF13374.6 EXF81172.1 - 2.8e-14 52.4 27.5 0.053 13.4 0.0 10.9 11 0 0 11 11 11 4 Tetratricopeptide repeat TPR_7 PF13176.6 EXF81172.1 - 9.3e-10 37.8 0.7 0.03 14.3 0.0 7.0 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_2 PF07719.17 EXF81172.1 - 1.3e-07 31.1 2.2 4.3 7.7 0.0 7.1 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_14 PF13428.6 EXF81172.1 - 1.5e-07 31.6 6.7 1.6 9.7 0.0 6.5 6 1 1 7 7 5 2 Tetratricopeptide repeat TPR_16 PF13432.6 EXF81172.1 - 1.6e-07 31.9 4.4 6.9 7.4 0.1 6.6 6 1 1 7 7 7 2 Tetratricopeptide repeat TPR_1 PF00515.28 EXF81172.1 - 2.4e-06 27.1 0.3 10 6.1 0.0 5.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_4 PF07721.14 EXF81172.1 - 9.8e-06 25.7 8.6 2.5 9.0 0.2 6.6 7 0 0 7 7 6 1 Tetratricopeptide repeat TPR_19 PF14559.6 EXF81172.1 - 0.0001 22.7 5.2 3.2 8.3 0.0 6.3 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_8 PF13181.6 EXF81172.1 - 0.00029 20.8 1.5 0.92 9.9 0.0 5.3 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_MalT PF17874.1 EXF81172.1 - 0.0033 16.8 0.5 0.0033 16.8 0.5 2.8 2 1 0 2 2 2 1 MalT-like TPR region TPR_6 PF13174.6 EXF81172.1 - 0.035 14.7 1.1 2.7e+02 2.6 0.0 6.0 7 0 0 7 7 6 0 Tetratricopeptide repeat 3Beta_HSD PF01073.19 EXF81173.1 - 1.7e-55 188.0 0.0 2.2e-55 187.7 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EXF81173.1 - 6.7e-33 114.1 0.0 8.7e-33 113.8 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EXF81173.1 - 6e-23 81.8 0.1 3.9e-22 79.1 0.1 2.1 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 EXF81173.1 - 1.5e-17 63.6 0.1 1.1e-10 41.2 0.0 2.2 2 0 0 2 2 2 2 Male sterility protein RmlD_sub_bind PF04321.17 EXF81173.1 - 3.9e-14 52.4 0.1 5.3e-14 52.0 0.1 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_10 PF13460.6 EXF81173.1 - 1.2e-11 44.9 0.1 1.9e-11 44.2 0.1 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Polysacc_synt_2 PF02719.15 EXF81173.1 - 1.4e-10 40.8 0.3 7.3e-09 35.2 0.8 2.8 2 1 0 2 2 2 1 Polysaccharide biosynthesis protein KR PF08659.10 EXF81173.1 - 1.4e-08 34.8 0.7 8.3e-08 32.3 0.7 2.0 1 1 0 1 1 1 1 KR domain NmrA PF05368.13 EXF81173.1 - 0.081 12.5 0.3 0.15 11.6 0.3 1.4 1 0 0 1 1 1 0 NmrA-like family Exo_endo_phos PF03372.23 EXF81174.1 - 9.2e-17 61.3 0.2 2.9e-15 56.4 0.0 2.6 2 1 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family LRR_4 PF12799.7 EXF81174.1 - 1.1e-07 32.1 4.9 0.00018 21.8 0.2 2.6 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EXF81174.1 - 7.8e-07 28.8 5.8 1.4e-05 24.7 0.4 2.4 1 1 0 2 2 2 2 Leucine rich repeat TFIIA PF03153.13 EXF81174.1 - 0.56 10.1 7.5 0.87 9.5 7.5 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Methyltransf_25 PF13649.6 EXF81175.1 - 1.7e-14 54.3 0.0 3.6e-14 53.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF81175.1 - 1.2e-09 38.7 0.0 2.7e-09 37.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EXF81175.1 - 6.2e-08 32.6 0.0 5.8e-07 29.5 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF81175.1 - 4.3e-05 23.4 0.0 0.0001 22.1 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF81175.1 - 0.0004 21.1 0.0 0.00095 19.9 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EXF81175.1 - 0.0013 18.1 0.0 0.0021 17.4 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family FtsJ PF01728.19 EXF81175.1 - 0.0092 16.1 0.0 0.018 15.1 0.0 1.4 1 0 0 1 1 1 1 FtsJ-like methyltransferase Na_H_antiporter PF03553.14 EXF81175.1 - 0.18 11.0 1.0 0.31 10.2 1.0 1.2 1 0 0 1 1 1 0 Na+/H+ antiporter family DUF3287 PF11690.8 EXF81177.1 - 0.052 13.3 1.2 0.15 11.8 0.8 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3287) COG5 PF10392.9 EXF81177.1 - 2.3 8.4 5.1 2 8.6 1.3 2.4 2 0 0 2 2 2 0 Golgi transport complex subunit 5 Jnk-SapK_ap_N PF09744.9 EXF81177.1 - 7.6 6.7 26.9 0.057 13.6 1.2 3.1 1 1 2 3 3 3 0 JNK_SAPK-associated protein-1 Macoilin PF09726.9 EXF81178.1 - 3 6.3 17.5 3.3 6.2 17.5 1.0 1 0 0 1 1 1 0 Macoilin family DASH_Ask1 PF08655.10 EXF81179.1 - 5.2e-31 106.3 0.3 8e-31 105.7 0.3 1.3 1 0 0 1 1 1 1 DASH complex subunit Ask1 DUF3073 PF11273.8 EXF81179.1 - 1.1 10.1 4.2 0.77 10.6 0.2 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3073) GCP_C_terminal PF04130.13 EXF81180.1 - 2.8e-79 266.8 0.0 4.5e-78 262.8 0.0 2.1 2 0 0 2 2 2 1 Gamma tubulin complex component C-terminal GCP_N_terminal PF17681.1 EXF81180.1 - 1.1e-29 104.1 0.0 1.9e-29 103.3 0.0 1.4 1 1 0 1 1 1 1 Gamma tubulin complex component N-terminal DUF3510 PF12022.8 EXF81180.1 - 0.068 13.6 0.0 0.22 11.9 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3510) Eaf7 PF07904.13 EXF81181.1 - 3.4e-26 91.7 0.2 3.4e-26 91.7 0.2 2.3 2 1 0 2 2 2 1 Chromatin modification-related protein EAF7 GAGA_bind PF06217.12 EXF81181.1 - 0.25 11.6 3.9 0.36 11.1 3.9 1.3 1 0 0 1 1 1 0 GAGA binding protein-like family Myb_DNA-bind_7 PF15963.5 EXF81182.1 - 0.048 13.6 0.3 0.81 9.6 0.0 2.6 2 0 0 2 2 2 0 Myb DNA-binding like Myb_DNA-binding PF00249.31 EXF81182.1 - 0.097 12.9 1.2 0.3 11.3 0.0 2.5 3 0 0 3 3 3 0 Myb-like DNA-binding domain ResIII PF04851.15 EXF81183.1 - 2.5e-26 92.7 0.0 9.8e-26 90.8 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EXF81183.1 - 9e-17 61.4 0.0 3e-15 56.5 0.0 2.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 EXF81183.1 - 4e-12 46.3 0.0 4.4e-11 42.9 0.0 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase SWI2_SNF2 PF18766.1 EXF81183.1 - 7.5e-06 25.8 0.0 1.8e-05 24.6 0.0 1.6 1 0 0 1 1 1 1 SWI2/SNF2 ATPase ERCC3_RAD25_C PF16203.5 EXF81183.1 - 0.00021 20.6 0.0 0.00042 19.6 0.0 1.5 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase DUF2075 PF09848.9 EXF81183.1 - 0.011 15.0 0.0 0.022 14.0 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Helicase_C_2 PF13307.6 EXF81183.1 - 0.086 13.0 0.1 1.1 9.4 0.0 2.5 2 0 0 2 2 2 0 Helicase C-terminal domain SwrA PF17423.2 EXF81183.1 - 0.13 12.3 0.0 0.35 10.9 0.0 1.7 1 0 0 1 1 1 0 Swarming motility protein KH_1 PF00013.29 EXF81184.1 - 2.9e-30 103.9 1.0 3.5e-07 30.0 0.0 7.6 8 0 0 8 8 8 5 KH domain HAD_2 PF13419.6 EXF81186.1 - 2.4e-12 47.3 0.0 3.5e-12 46.8 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EXF81186.1 - 1.1e-11 45.5 0.0 4.9e-11 43.3 0.0 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EXF81186.1 - 0.0018 18.3 0.0 0.003 17.6 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like HAD PF12710.7 EXF81186.1 - 0.0078 16.6 0.0 0.011 16.2 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Med21 PF11221.8 EXF81187.1 - 4.1e-48 163.3 7.1 4.5e-48 163.2 7.1 1.0 1 0 0 1 1 1 1 Subunit 21 of Mediator complex GAS PF13851.6 EXF81187.1 - 0.00029 20.3 4.4 0.063 12.6 0.1 2.1 2 0 0 2 2 2 2 Growth-arrest specific micro-tubule binding Med9 PF07544.13 EXF81187.1 - 0.001 19.1 1.0 0.001 19.1 1.0 3.0 2 1 1 3 3 3 1 RNA polymerase II transcription mediator complex subunit 9 T3SS_needle_E PF08988.10 EXF81187.1 - 0.059 13.5 1.9 0.54 10.4 0.8 2.3 2 0 0 2 2 2 0 Type III secretion system, cytoplasmic E component of needle DUF3802 PF12290.8 EXF81187.1 - 0.074 13.6 1.5 0.17 12.4 1.5 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3802) Fib_alpha PF08702.10 EXF81187.1 - 0.21 11.8 2.9 0.46 10.7 1.2 2.0 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family TMF_DNA_bd PF12329.8 EXF81187.1 - 0.57 10.2 6.9 5.2 7.1 6.9 2.2 1 1 0 1 1 1 0 TATA element modulatory factor 1 DNA binding HIP1_clath_bdg PF16515.5 EXF81187.1 - 1.6 9.4 8.1 1.2 9.8 1.3 2.6 1 1 2 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF2034 PF10356.9 EXF81188.1 - 8.1e-29 100.4 0.0 2.7e-14 53.0 0.0 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF2034) Mrr_cat PF04471.12 EXF81188.1 - 7.8e-07 29.1 0.0 1.7e-06 28.0 0.0 1.5 2 0 0 2 2 2 1 Restriction endonuclease DUF3176 PF11374.8 EXF81189.1 - 1.6e-23 82.9 5.4 2.9e-22 78.9 2.0 3.3 2 1 0 2 2 2 1 Protein of unknown function (DUF3176) DUF2975 PF11188.8 EXF81189.1 - 0.64 9.9 3.7 1.3 8.9 3.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2975) Cullin PF00888.22 EXF81190.1 - 3.6e-196 653.5 10.2 5e-196 653.0 10.2 1.2 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 EXF81190.1 - 3.5e-26 91.0 6.5 5.4e-26 90.4 4.6 2.5 2 0 0 2 2 2 1 Cullin protein neddylation domain WAC_Acf1_DNA_bd PF10537.9 EXF81190.1 - 0.032 14.8 3.5 0.033 14.7 0.5 2.6 3 0 0 3 3 3 0 ATP-utilising chromatin assembly and remodelling N-terminal DUF1803 PF08820.10 EXF81190.1 - 0.13 12.3 1.6 3.4 7.8 0.1 3.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1803) Bcl-2_3 PF15286.6 EXF81191.1 - 0.0079 16.9 0.0 0.015 16.0 0.0 1.4 1 0 0 1 1 1 1 Apoptosis regulator M11, B cell 2 leukaemia/lymphoma like MARVEL PF01284.23 EXF81191.1 - 0.19 11.8 3.8 0.29 11.2 3.8 1.3 1 0 0 1 1 1 0 Membrane-associating domain Mit_KHE1 PF10173.9 EXF81192.1 - 2.3e-62 210.5 0.1 2.3e-62 210.5 0.1 1.4 2 0 0 2 2 2 1 Mitochondrial K+-H+ exchange-related GATA PF00320.27 EXF81193.1 - 3.3e-15 55.4 2.9 1.3e-14 53.4 2.7 2.0 2 0 0 2 2 2 1 GATA zinc finger ATG16 PF08614.11 EXF81193.1 - 0.012 15.8 8.6 0.012 15.8 8.6 3.0 3 1 0 3 3 3 0 Autophagy protein 16 (ATG16) DUF834 PF05754.14 EXF81193.1 - 0.025 14.6 3.0 0.063 13.3 3.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF834) ArfGap PF01412.18 EXF81193.1 - 0.038 14.1 0.1 0.094 12.8 0.1 1.7 1 0 0 1 1 1 0 Putative GTPase activating protein for Arf LcrG PF07216.12 EXF81193.1 - 0.14 12.1 0.3 0.14 12.1 0.3 2.2 2 0 0 2 2 2 0 LcrG protein HOOK PF05622.12 EXF81193.1 - 0.23 9.6 9.8 0.013 13.6 4.5 1.5 2 0 0 2 2 2 0 HOOK protein KH_8 PF17903.1 EXF81194.1 - 1.7e-30 105.0 0.0 3.7e-30 103.9 0.0 1.6 1 0 0 1 1 1 1 Krr1 KH1 domain KH_1 PF00013.29 EXF81194.1 - 0.0044 16.8 0.0 0.011 15.5 0.0 1.7 1 0 0 1 1 1 1 KH domain ADH_zinc_N PF00107.26 EXF81196.1 - 1.8e-21 76.5 0.5 2.8e-21 75.9 0.5 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EXF81196.1 - 7e-11 43.3 0.1 2e-10 41.8 0.1 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EXF81196.1 - 0.001 18.9 0.0 0.0023 17.8 0.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain adh_short PF00106.25 EXF81196.1 - 0.15 11.5 0.7 0.25 10.8 0.7 1.5 1 1 0 1 1 1 0 short chain dehydrogenase Sulf_transp PF04143.14 EXF81197.1 - 1.8e-31 109.8 26.1 2.8e-31 109.3 25.6 1.6 1 1 0 1 1 1 1 Sulphur transport Ank_2 PF12796.7 EXF81198.1 - 2.8e-55 184.9 4.5 9.9e-11 42.1 0.0 5.4 1 1 6 7 7 7 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EXF81198.1 - 5.5e-34 116.1 3.7 0.00011 22.7 0.0 7.7 4 3 4 8 8 8 8 Ankyrin repeats (many copies) Ank PF00023.30 EXF81198.1 - 1.1e-29 101.5 1.1 0.013 15.9 0.0 10.2 9 0 0 9 9 9 8 Ankyrin repeat Ank_3 PF13606.6 EXF81198.1 - 3e-28 94.8 1.1 0.016 15.7 0.0 9.7 10 0 0 10 10 10 7 Ankyrin repeat Ank_5 PF13857.6 EXF81198.1 - 1.7e-20 72.8 5.1 0.00062 20.0 0.0 7.8 3 1 4 8 8 8 7 Ankyrin repeats (many copies) SAP PF02037.27 EXF81199.1 - 1.6e-07 30.9 0.1 2.8e-07 30.1 0.1 1.4 1 0 0 1 1 1 1 SAP domain zf-RING_2 PF13639.6 EXF81199.1 - 0.0012 19.2 11.5 0.0012 19.2 11.5 2.0 2 0 0 2 2 2 1 Ring finger domain PHD PF00628.29 EXF81199.1 - 0.0091 15.9 11.9 0.02 14.8 11.9 1.6 1 0 0 1 1 1 1 PHD-finger Prok-RING_1 PF14446.6 EXF81199.1 - 0.013 15.4 8.0 0.013 15.4 8.0 1.7 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 Rad50_zn_hook PF04423.14 EXF81199.1 - 0.12 12.2 0.7 1.7 8.6 0.4 2.4 2 0 0 2 2 2 0 Rad50 zinc hook motif zf-C3HC4_2 PF13923.6 EXF81199.1 - 0.82 9.6 9.8 1.1 9.1 6.8 2.4 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Vps39_2 PF10367.9 EXF81199.1 - 1 9.8 4.1 0.64 10.5 1.3 2.1 2 0 0 2 2 2 0 Vacuolar sorting protein 39 domain 2 C1_1 PF00130.22 EXF81199.1 - 3.7 7.5 13.8 0.35 10.8 7.9 2.2 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-RING_5 PF14634.6 EXF81199.1 - 7.5 6.6 15.2 2.7 8.0 11.4 2.1 2 0 0 2 2 2 0 zinc-RING finger domain DUF2116 PF09889.9 EXF81199.1 - 7.6 6.6 8.6 17 5.5 8.6 1.6 1 0 0 1 1 1 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) Ribonuc_L-PSP PF01042.21 EXF81200.1 - 1e-26 93.3 0.3 1.1e-26 93.2 0.3 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP DUF1320 PF07030.12 EXF81200.1 - 0.029 14.5 0.0 0.045 13.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1320) Halogen_Hydrol PF10112.9 EXF81201.1 - 0.11 12.5 0.1 0.14 12.2 0.1 1.0 1 0 0 1 1 1 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein Ysc84 PF04366.12 EXF81202.1 - 6.4e-31 106.8 0.0 1.2e-30 105.9 0.0 1.5 1 0 0 1 1 1 1 Las17-binding protein actin regulator Actin PF00022.19 EXF81203.1 - 7.1e-16 57.8 0.0 2.1e-14 53.0 0.0 2.6 3 0 0 3 3 3 1 Actin FtsA PF14450.6 EXF81203.1 - 0.069 13.6 0.0 0.15 12.5 0.0 1.8 1 1 0 1 1 1 0 Cell division protein FtsA Fungal_trans PF04082.18 EXF81205.1 - 1.7e-11 43.7 0.5 3.4e-11 42.7 0.5 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-H2C2_2 PF13465.6 EXF81205.1 - 1.5e-06 28.3 7.3 1.9e-05 24.9 1.1 2.8 2 0 0 2 2 2 2 Zinc-finger double domain zf-Di19 PF05605.12 EXF81205.1 - 0.00077 19.7 4.4 0.0016 18.7 4.4 1.5 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.6 EXF81205.1 - 0.0013 19.4 15.1 0.065 14.1 5.8 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EXF81205.1 - 0.18 12.2 3.1 9 6.7 0.8 2.7 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.26 EXF81205.1 - 0.34 11.5 14.6 0.38 11.3 7.3 2.8 2 0 0 2 2 2 0 Zinc finger, C2H2 type SBP_bac_8 PF13416.6 EXF81206.1 - 3.6e-11 43.4 4.4 1.7e-10 41.2 4.4 1.8 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_6 PF13343.6 EXF81206.1 - 2.9e-10 40.0 1.4 4.4e-10 39.4 1.4 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_11 PF13531.6 EXF81206.1 - 5.4e-05 23.0 0.0 9.2e-05 22.3 0.0 1.4 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 EXF81206.1 - 0.001 19.1 7.6 0.0025 17.8 6.9 2.0 1 1 1 2 2 2 1 Bacterial extracellular solute-binding protein Aminotran_1_2 PF00155.21 EXF81207.1 - 3.6e-46 158.0 0.0 4.4e-46 157.7 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Arrestin_C PF02752.22 EXF81208.1 - 1.5e-14 54.6 0.0 1.1e-13 51.7 0.0 2.3 1 1 0 1 1 1 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 EXF81208.1 - 4.7e-07 30.0 0.0 0.01 15.9 0.0 2.4 2 0 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain NUDIX PF00293.28 EXF81209.1 - 2.7e-15 56.5 0.8 4.4e-15 55.9 0.8 1.2 1 0 0 1 1 1 1 NUDIX domain NUDIX_4 PF14815.6 EXF81209.1 - 0.054 13.5 0.1 0.11 12.4 0.1 1.6 1 1 0 1 1 1 0 NUDIX domain YabA PF06156.13 EXF81211.1 - 0.00045 20.8 9.4 0.06 14.0 1.7 2.5 1 1 1 2 2 2 2 Initiation control protein YabA DivIC PF04977.15 EXF81211.1 - 0.00094 18.9 7.1 0.0055 16.5 0.7 2.4 2 0 0 2 2 2 1 Septum formation initiator DUF4201 PF13870.6 EXF81211.1 - 0.003 17.3 5.9 0.062 13.0 0.1 2.3 2 1 0 2 2 2 2 Domain of unknown function (DUF4201) Filament PF00038.21 EXF81211.1 - 0.012 15.3 5.2 0.37 10.3 1.0 2.2 2 0 0 2 2 2 0 Intermediate filament protein Alanine_zipper PF11839.8 EXF81211.1 - 0.037 14.4 4.9 0.087 13.2 4.9 1.6 1 0 0 1 1 1 0 Alanine-zipper, major outer membrane lipoprotein Seadorna_VP6 PF07407.11 EXF81211.1 - 0.083 11.8 1.0 0.11 11.4 1.0 1.1 1 0 0 1 1 1 0 Seadornavirus VP6 protein GAS PF13851.6 EXF81211.1 - 0.11 11.9 9.4 0.11 11.9 8.0 1.6 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding CASP_C PF08172.12 EXF81211.1 - 0.14 11.4 11.0 0.3 10.4 11.0 1.5 1 1 0 1 1 1 0 CASP C terminal HOOK PF05622.12 EXF81211.1 - 0.33 9.1 9.6 1.3 7.0 9.6 1.8 1 1 0 1 1 1 0 HOOK protein ADIP PF11559.8 EXF81211.1 - 0.41 10.7 13.6 1.2 9.2 0.9 2.4 1 1 0 2 2 2 0 Afadin- and alpha -actinin-Binding NRBF2 PF08961.10 EXF81211.1 - 0.42 10.2 11.1 0.068 12.8 0.7 2.9 2 1 1 3 3 3 0 Nuclear receptor-binding factor 2, autophagy regulator FUSC PF04632.12 EXF81211.1 - 0.81 8.1 8.4 0.5 8.8 3.4 1.7 1 1 1 2 2 2 0 Fusaric acid resistance protein family Atg14 PF10186.9 EXF81211.1 - 1.4 7.9 4.1 2.3 7.2 4.1 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 TolA_bind_tri PF16331.5 EXF81211.1 - 1.7 8.8 8.5 4.4 7.5 0.2 2.4 2 0 0 2 2 2 0 TolA binding protein trimerisation HALZ PF02183.18 EXF81211.1 - 2.7 8.3 10.3 17 5.8 0.6 3.6 4 0 0 4 4 3 0 Homeobox associated leucine zipper ZapB PF06005.12 EXF81211.1 - 5 7.6 15.5 0.28 11.7 5.4 2.8 2 1 1 3 3 3 0 Cell division protein ZapB CENP-H PF05837.12 EXF81211.1 - 6.6 7.2 13.2 13 6.2 1.3 2.3 1 1 1 2 2 2 0 Centromere protein H (CENP-H) PikAIV_N PF18605.1 EXF81211.1 - 8.7 6.0 18.5 1.1 8.9 0.6 3.7 4 0 0 4 4 4 0 Narbonolide/10-deoxymethynolide synthase PikA4 N-terminal domain Flu_M2 PF00599.17 EXF81212.1 - 0.027 14.6 0.0 0.05 13.7 0.0 1.4 1 0 0 1 1 1 0 Influenza Matrix protein (M2) ATP-synt_8 PF00895.20 EXF81213.1 - 1.1 9.7 3.6 2.5 8.6 1.0 2.2 1 1 1 2 2 2 0 ATP synthase protein 8 PIG-L PF02585.17 EXF81214.1 - 7.6e-11 42.8 0.0 1.3e-10 42.0 0.0 1.3 1 0 0 1 1 1 1 GlcNAc-PI de-N-acetylase AGH PF17558.2 EXF81214.1 - 0.1 12.7 0.1 0.22 11.7 0.0 1.5 2 0 0 2 2 2 0 Androgenic gland hormone ATP13 PF12921.7 EXF81215.1 - 9.7e-16 57.7 0.0 2.4e-15 56.4 0.0 1.7 1 0 0 1 1 1 1 Mitochondrial ATPase expression LSM PF01423.22 EXF81216.1 - 7.4e-19 67.2 0.2 9.3e-19 66.9 0.2 1.1 1 0 0 1 1 1 1 LSM domain GTP_EFTU PF00009.27 EXF81217.1 - 6.4e-19 68.3 0.0 1.2e-18 67.4 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 EXF81217.1 - 6.8e-09 36.0 0.4 4.6e-08 33.3 0.3 2.4 2 0 0 2 2 2 1 Elongation factor Tu domain 2 GTP_EFTU_D3 PF03143.17 EXF81217.1 - 0.00011 22.4 0.0 0.00031 21.0 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain MMR_HSR1 PF01926.23 EXF81217.1 - 0.00012 22.1 0.3 0.00061 19.9 0.2 2.2 2 1 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EXF81217.1 - 0.00052 20.0 0.7 0.64 9.9 0.2 2.5 2 0 0 2 2 2 2 RsgA GTPase PduV-EutP PF10662.9 EXF81217.1 - 0.0055 16.4 0.3 0.73 9.6 0.1 3.2 2 1 1 3 3 3 1 Ethanolamine utilisation - propanediol utilisation Dynamin_N PF00350.23 EXF81217.1 - 0.071 13.2 0.7 0.16 12.0 0.1 1.9 2 0 0 2 2 2 0 Dynamin family Roc PF08477.13 EXF81217.1 - 0.14 12.3 0.1 1.1 9.5 0.0 2.3 1 1 1 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Zn_clus PF00172.18 EXF81218.1 - 1.1e-07 31.8 7.0 2e-07 31.0 7.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF3433 PF11915.8 EXF81219.1 - 1.6e-33 115.0 20.2 7.4e-21 74.4 0.6 3.3 3 0 0 3 3 3 2 Protein of unknown function (DUF3433) DUF3433 PF11915.8 EXF81221.1 - 6.8e-24 84.1 20.3 4.2e-19 68.8 1.5 3.4 3 0 0 3 3 3 2 Protein of unknown function (DUF3433) DUF3671 PF12420.8 EXF81221.1 - 0.11 12.6 3.0 0.17 12.0 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function Nha1_C PF08619.10 EXF81224.1 - 1e-130 437.1 30.1 1.3e-130 436.8 30.1 1.0 1 0 0 1 1 1 1 Alkali metal cation/H+ antiporter Nha1 C terminus Na_H_Exchanger PF00999.21 EXF81224.1 - 1.2e-75 254.7 23.7 1.5e-75 254.4 23.7 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family SUKH-4 PF14435.6 EXF81224.1 - 0.027 14.5 0.0 0.08 13.0 0.0 1.8 1 0 0 1 1 1 0 SUKH-4 immunity protein YrhC PF14143.6 EXF81224.1 - 7.1 6.8 8.9 0.45 10.6 0.2 3.0 3 0 0 3 3 3 0 YrhC-like protein K_oxygenase PF13434.6 EXF81227.1 - 1.1e-13 51.0 0.0 3.9e-12 46.0 0.0 2.3 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) FMO-like PF00743.19 EXF81227.1 - 1.6e-10 40.0 0.0 2.5e-10 39.4 0.0 1.1 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 EXF81227.1 - 2.9e-09 36.6 0.0 1.2e-08 34.6 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EXF81227.1 - 6.2e-09 35.5 0.0 1.3e-08 34.5 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EXF81227.1 - 0.00013 22.1 0.0 0.00037 20.7 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 EXF81227.1 - 0.00078 18.7 0.1 0.0059 15.9 0.0 2.3 3 0 0 3 3 3 1 Thi4 family DAO PF01266.24 EXF81227.1 - 0.0049 16.5 0.1 1.6 8.2 0.0 2.9 2 1 1 3 3 3 2 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EXF81227.1 - 0.0088 16.0 0.1 0.54 10.2 0.1 3.1 2 1 0 2 2 2 1 FAD-NAD(P)-binding FAD_binding_2 PF00890.24 EXF81227.1 - 0.058 12.5 0.0 0.66 9.0 0.0 2.1 2 0 0 2 2 2 0 FAD binding domain Trypsin_2 PF13365.6 EXF81228.1 - 2.6e-27 96.6 0.0 4.5e-27 95.8 0.0 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.26 EXF81228.1 - 0.00021 21.2 0.0 0.0011 18.8 0.0 2.0 1 1 0 1 1 1 1 Trypsin Peptidase_S46 PF10459.9 EXF81228.1 - 0.016 13.9 0.0 0.082 11.5 0.0 1.9 2 0 0 2 2 2 0 Peptidase S46 Peptidase_S32 PF05579.13 EXF81228.1 - 0.023 13.9 0.3 0.047 12.9 0.1 1.5 2 0 0 2 2 2 0 Equine arteritis virus serine endopeptidase S32 Peptidase_C4 PF00863.19 EXF81228.1 - 0.25 10.6 0.1 0.79 9.0 0.1 1.7 2 0 0 2 2 2 0 Peptidase family C4 AP3B1_C PF14796.6 EXF81229.1 - 0.18 12.1 0.6 0.26 11.6 0.6 1.2 1 0 0 1 1 1 0 Clathrin-adaptor complex-3 beta-1 subunit C-terminal Cofilin_ADF PF00241.20 EXF81230.1 - 0.02 14.7 0.8 0.051 13.4 0.0 2.1 3 0 0 3 3 3 0 Cofilin/tropomyosin-type actin-binding protein Dynamin_N PF00350.23 EXF81231.1 - 1.5e-17 64.1 0.1 4.3e-17 62.7 0.0 1.8 2 0 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.23 EXF81231.1 - 4e-10 39.8 0.0 2.4e-09 37.3 0.0 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EXF81231.1 - 1.5e-06 27.9 1.2 4.3e-05 23.1 0.9 2.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain cobW PF02492.19 EXF81231.1 - 0.023 14.3 0.7 0.58 9.7 0.7 2.7 2 1 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain TsaE PF02367.17 EXF81231.1 - 0.043 13.8 0.0 0.14 12.2 0.0 1.8 1 1 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Roc PF08477.13 EXF81231.1 - 0.06 13.6 0.1 0.9 9.8 0.0 2.4 1 1 1 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_18 PF13238.6 EXF81231.1 - 0.061 13.9 0.0 0.21 12.1 0.0 2.0 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EXF81231.1 - 0.067 12.9 0.1 0.3 10.8 0.0 2.0 2 0 0 2 2 2 0 P-loop containing region of AAA domain IIGP PF05049.13 EXF81231.1 - 0.082 12.0 0.0 0.16 11.0 0.0 1.4 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) MSA-2c PF12238.8 EXF81231.1 - 0.088 12.8 3.5 0.088 12.8 1.2 2.2 2 0 0 2 2 2 0 Merozoite surface antigen 2c DUF2408 PF10303.9 EXF81231.1 - 0.35 11.4 1.9 5.4 7.6 0.1 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF2408) Snf7 PF03357.21 EXF81232.1 - 3.4e-21 75.6 28.9 2.2e-15 56.7 12.7 2.4 2 1 1 3 3 3 2 Snf7 CaMBD PF02888.16 EXF81232.1 - 0.022 14.9 1.2 0.022 14.9 1.2 1.8 2 0 0 2 2 2 0 Calmodulin binding domain Mer2 PF09074.10 EXF81232.1 - 0.051 13.4 3.8 0.067 13.0 3.8 1.3 1 0 0 1 1 1 0 Mer2 GCN5L1 PF06320.13 EXF81232.1 - 0.084 13.0 1.0 0.084 13.0 1.0 2.1 2 0 0 2 2 2 0 GCN5-like protein 1 (GCN5L1) Exonuc_VII_L PF02601.15 EXF81232.1 - 0.26 10.8 3.8 0.36 10.3 3.8 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit YojJ PF10372.9 EXF81232.1 - 0.31 11.2 5.0 0.58 10.3 0.4 2.8 2 1 1 3 3 3 0 Bacterial membrane-spanning protein N-terminus DUF3958 PF13125.6 EXF81232.1 - 0.35 11.1 6.4 0.074 13.3 2.1 1.9 1 1 0 2 2 2 0 Protein of unknown function (DUF3958) PspA_IM30 PF04012.12 EXF81232.1 - 0.44 10.1 14.9 1 8.9 14.9 1.5 1 1 0 1 1 1 0 PspA/IM30 family V_ATPase_I PF01496.19 EXF81232.1 - 0.81 7.5 4.8 0.89 7.4 4.8 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CCAP PF11105.8 EXF81232.1 - 0.82 9.6 6.2 0.12 12.4 1.1 1.9 1 1 0 2 2 2 0 Arthropod cardioacceleratory peptide 2a HXXSHH PF07586.11 EXF81232.1 - 2.5 7.6 6.9 12 5.3 2.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1552) PP2C PF00481.21 EXF81233.1 - 8.2e-64 215.7 0.2 1.7e-52 178.6 0.2 2.9 1 1 1 2 2 2 2 Protein phosphatase 2C Zn_clus PF00172.18 EXF81234.1 - 2.9e-07 30.5 12.1 4.7e-07 29.8 12.1 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain LCE6A PF15858.5 EXF81234.1 - 9.4 7.1 10.9 0.3 11.9 3.5 2.4 2 0 0 2 2 2 0 Late cornified envelope protein 6A family YEATS PF03366.16 EXF81235.1 - 3.9e-21 74.8 0.0 7.7e-21 73.9 0.0 1.5 1 0 0 1 1 1 1 YEATS family BET PF17035.5 EXF81235.1 - 1.5e-05 25.1 1.0 0.0049 17.0 0.2 3.0 3 0 0 3 3 3 2 Bromodomain extra-terminal - transcription regulation p25-alpha PF05517.12 EXF81235.1 - 0.0058 16.8 0.2 0.044 14.0 0.2 2.1 1 1 1 2 2 2 1 p25-alpha MgtE_N PF03448.17 EXF81235.1 - 0.04 14.5 0.1 0.075 13.6 0.1 1.4 1 0 0 1 1 1 0 MgtE intracellular N domain WWE PF02825.20 EXF81235.1 - 0.058 14.0 0.1 0.22 12.1 0.1 1.9 2 0 0 2 2 2 0 WWE domain DUF3791 PF12668.7 EXF81235.1 - 0.13 12.4 0.0 0.44 10.6 0.0 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3791) Ran_BP1 PF00638.18 EXF81236.1 - 1.4e-49 167.4 1.4 2.3e-49 166.7 1.4 1.3 1 0 0 1 1 1 1 RanBP1 domain WH1 PF00568.23 EXF81236.1 - 0.0014 18.5 0.2 0.0052 16.7 0.2 1.8 1 1 0 1 1 1 1 WH1 domain CDC27 PF09507.10 EXF81236.1 - 0.1 12.0 13.5 0.16 11.4 13.5 1.3 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 PHD20L1_u1 PF16660.5 EXF81236.1 - 0.25 12.1 2.3 0.48 11.2 2.3 1.4 1 0 0 1 1 1 0 PHD finger protein 20-like protein 1 FeoB_Cyto PF17910.1 EXF81237.1 - 0.38 11.3 2.6 2.4 8.8 1.8 2.5 2 0 0 2 2 2 0 FeoB cytosolic helical domain Phosducin PF02114.16 EXF81238.1 - 4.9e-09 35.5 0.1 7.2e-08 31.7 0.1 2.2 1 1 0 1 1 1 1 Phosducin WD40 PF00400.32 EXF81240.1 - 1.3e-37 127.1 19.6 3.1e-07 31.0 0.1 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EXF81240.1 - 2.4e-14 53.4 0.0 0.00038 20.7 0.1 4.7 1 1 4 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EXF81240.1 - 7.3e-05 21.9 0.1 0.8 8.6 0.0 3.9 3 1 1 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 EXF81240.1 - 8.9e-05 22.4 0.0 0.11 12.3 0.0 2.8 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 EXF81240.1 - 0.00071 19.0 0.0 0.05 12.9 0.0 2.9 2 1 1 3 3 3 1 WD40-like domain CwfJ_C_1 PF04677.15 EXF81241.1 - 1.2e-23 83.3 0.0 2.1e-23 82.5 0.0 1.3 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 CwfJ_C_2 PF04676.14 EXF81241.1 - 6.8e-15 55.8 1.6 1.6e-14 54.5 1.2 1.9 2 0 0 2 2 2 1 Protein similar to CwfJ C-terminus 2 DRIM PF07539.12 EXF81242.1 - 2.6e-203 676.8 6.9 4e-203 676.2 4.3 2.8 3 0 0 3 3 3 1 Down-regulated in metastasis HEAT PF02985.22 EXF81242.1 - 0.00021 21.2 4.0 11 6.6 0.1 7.6 8 0 0 8 8 8 2 HEAT repeat CNOT11 PF10155.9 EXF81242.1 - 1.4 9.1 4.4 42 4.3 1.2 4.3 4 0 0 4 4 4 0 CCR4-NOT transcription complex subunit 11 V-ATPase_H_C PF11698.8 EXF81242.1 - 4.3 7.5 7.5 33 4.6 0.0 5.6 5 1 1 6 6 6 0 V-ATPase subunit H zf-DNL PF05180.12 EXF81243.1 - 4.1e-28 97.1 0.3 5.6e-28 96.7 0.3 1.2 1 0 0 1 1 1 1 DNL zinc finger JHY PF15261.6 EXF81243.1 - 0.035 14.8 0.9 0.058 14.1 0.9 1.4 1 0 0 1 1 1 0 Jhy protein zf-CSL PF05207.13 EXF81243.1 - 0.17 11.6 0.3 0.3 10.8 0.3 1.3 1 0 0 1 1 1 0 CSL zinc finger Cullin PF00888.22 EXF81244.1 - 3.8e-199 663.3 6.5 3.8e-199 663.3 6.5 1.3 2 0 0 2 2 2 1 Cullin family Cullin_Nedd8 PF10557.9 EXF81244.1 - 9.2e-27 92.9 0.9 2.8e-26 91.3 0.9 1.9 1 0 0 1 1 1 1 Cullin protein neddylation domain RGS PF00615.19 EXF81244.1 - 0.0091 16.3 0.4 0.029 14.7 0.4 1.9 1 0 0 1 1 1 1 Regulator of G protein signaling domain DUF3405 PF11885.8 EXF81244.1 - 0.031 12.9 0.2 0.087 11.4 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3405) MA3 PF02847.17 EXF81244.1 - 0.037 14.0 0.4 0.25 11.4 0.0 2.5 2 0 0 2 2 2 0 MA3 domain HEPN_DZIP3 PF18738.1 EXF81244.1 - 0.038 13.7 0.4 1.1 9.0 0.0 2.6 2 0 0 2 2 2 0 DZIP3/ hRUL138-like HEPN HTH_IclR PF09339.10 EXF81244.1 - 0.17 11.7 0.1 0.65 9.8 0.1 2.0 2 0 0 2 2 2 0 IclR helix-turn-helix domain Abhydrolase_3 PF07859.13 EXF81245.1 - 1.2e-29 103.7 0.0 3.2e-29 102.3 0.0 1.6 2 0 0 2 2 2 1 alpha/beta hydrolase fold COesterase PF00135.28 EXF81245.1 - 6.2e-06 25.3 0.0 4e-05 22.7 0.0 1.8 2 0 0 2 2 2 1 Carboxylesterase family AXE1 PF05448.12 EXF81245.1 - 9.7e-05 21.2 0.0 0.00023 20.0 0.0 1.5 2 0 0 2 2 2 1 Acetyl xylan esterase (AXE1) Abhydrolase_6 PF12697.7 EXF81245.1 - 0.0021 18.7 0.4 0.0031 18.1 0.4 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 EXF81245.1 - 0.0077 15.7 0.0 0.013 15.0 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family BTB PF00651.31 EXF81246.1 - 9.7e-06 25.8 0.1 0.00085 19.5 0.0 2.2 2 0 0 2 2 2 2 BTB/POZ domain dCMP_cyt_deam_1 PF00383.23 EXF81247.1 - 5.8e-07 29.3 0.4 5.8e-07 29.3 0.4 1.6 2 0 0 2 2 2 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EXF81247.1 - 0.0098 15.7 0.4 0.036 13.8 0.4 1.9 1 1 0 1 1 1 1 MafB19-like deaminase BTB PF00651.31 EXF81248.1 - 1.2e-08 35.2 0.0 1.1e-06 28.8 0.0 3.0 3 1 0 3 3 3 2 BTB/POZ domain Peptidase_M3 PF01432.20 EXF81249.1 - 1.3e-157 525.7 0.0 1.9e-157 525.2 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M3 Peptidase_M2 PF01401.18 EXF81249.1 - 0.045 12.4 0.0 0.55 8.8 0.0 2.0 2 0 0 2 2 2 0 Angiotensin-converting enzyme EF-hand_7 PF13499.6 EXF81250.1 - 2.8e-13 50.1 0.2 3.5e-08 33.8 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_9 PF14658.6 EXF81250.1 - 2.8e-13 50.0 0.0 3.5e-07 30.4 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_6 PF13405.6 EXF81250.1 - 1.8e-10 39.9 0.2 0.0036 17.1 0.0 3.9 4 0 0 4 4 4 2 EF-hand domain EF-hand_1 PF00036.32 EXF81250.1 - 6.1e-10 37.9 0.2 0.021 14.4 0.0 4.0 4 1 0 4 4 4 2 EF hand EF-hand_8 PF13833.6 EXF81250.1 - 4.3e-08 32.9 0.1 3.4e-05 23.6 0.1 3.2 3 0 0 3 3 3 1 EF-hand domain pair FGAR-AT_linker PF18072.1 EXF81250.1 - 0.093 13.3 0.0 4.7 7.8 0.1 2.3 2 0 0 2 2 2 0 Formylglycinamide ribonucleotide amidotransferase linker domain EF-hand_14 PF17959.1 EXF81250.1 - 0.17 12.3 0.0 25 5.3 0.0 2.4 2 1 0 2 2 2 0 EF-hand domain Methyltransf_11 PF08241.12 EXF81251.1 - 2.1e-19 70.0 0.0 3.4e-19 69.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF81251.1 - 3.8e-17 62.8 0.0 7.6e-17 61.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF81251.1 - 7e-09 36.3 0.0 1.1e-08 35.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF81251.1 - 1.1e-08 35.1 0.0 1.6e-08 34.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EXF81251.1 - 7.1e-07 29.2 0.0 1.2e-06 28.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EXF81251.1 - 1.9e-05 24.1 0.0 2.8e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 EXF81251.1 - 3.3e-05 23.5 0.0 9e-05 22.1 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase small domain DREV PF05219.12 EXF81251.1 - 0.0028 16.8 0.0 0.004 16.3 0.0 1.2 1 0 0 1 1 1 1 DREV methyltransferase Methyltransf_18 PF12847.7 EXF81251.1 - 0.028 14.4 0.0 0.082 12.8 0.0 1.6 2 0 0 2 2 2 0 Methyltransferase domain NodS PF05401.11 EXF81251.1 - 0.046 13.3 0.0 0.064 12.9 0.0 1.2 1 0 0 1 1 1 0 Nodulation protein S (NodS) PrmA PF06325.13 EXF81251.1 - 0.067 12.6 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) tRNA_U5-meth_tr PF05958.11 EXF81251.1 - 0.11 11.4 0.0 0.16 11.0 0.0 1.1 1 0 0 1 1 1 0 tRNA (Uracil-5-)-methyltransferase Methyltransf_32 PF13679.6 EXF81251.1 - 0.16 12.0 0.0 0.26 11.3 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_8 PF05148.15 EXF81251.1 - 0.23 11.3 0.0 0.99 9.2 0.0 1.8 1 1 0 1 1 1 0 Hypothetical methyltransferase CoA_binding_2 PF13380.6 EXF81252.1 - 9.4e-28 97.0 0.0 1.1e-27 96.8 0.0 1.1 1 0 0 1 1 1 1 CoA binding domain CoA_binding PF02629.19 EXF81252.1 - 0.14 12.9 0.0 0.21 12.3 0.0 1.2 1 0 0 1 1 1 0 CoA binding domain Gpr1_Fun34_YaaH PF01184.19 EXF81253.1 - 2e-27 96.2 22.9 2.5e-27 95.8 22.9 1.1 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family DUF5400 PF17379.2 EXF81253.1 - 0.15 12.5 5.8 0.25 11.8 5.4 1.5 1 1 0 1 1 1 0 Family of unknown function (DUF5400) BTB PF00651.31 EXF81254.1 - 3.4e-05 24.0 0.0 0.0012 19.0 0.0 2.2 2 0 0 2 2 2 2 BTB/POZ domain Cutinase PF01083.22 EXF81255.1 - 7.1e-33 114.0 0.2 8.7e-33 113.8 0.2 1.1 1 0 0 1 1 1 1 Cutinase PE-PPE PF08237.11 EXF81255.1 - 0.05 13.1 0.0 0.084 12.4 0.0 1.4 1 0 0 1 1 1 0 PE-PPE domain Abhydrolase_2 PF02230.16 EXF81255.1 - 0.095 12.5 0.0 0.15 11.9 0.0 1.2 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase VirJ PF06057.11 EXF81255.1 - 0.15 11.9 0.0 0.25 11.2 0.0 1.3 1 0 0 1 1 1 0 Bacterial virulence protein (VirJ) BIR PF00653.21 EXF81258.1 - 1.7e-44 150.3 8.1 1.3e-21 77.1 0.0 3.0 3 0 0 3 3 3 2 Inhibitor of Apoptosis domain AT_hook PF02178.19 EXF81258.1 - 0.5 10.4 12.8 0.19 11.7 1.5 3.9 2 1 0 2 2 2 0 AT hook motif HRXXH PF13933.6 EXF81259.1 - 3.3e-108 360.9 0.0 4.4e-108 360.5 0.0 1.1 1 0 0 1 1 1 1 Putative peptidase family Aspzincin_M35 PF14521.6 EXF81259.1 - 2.1e-06 28.3 0.1 5.5e-06 27.0 0.1 1.7 1 0 0 1 1 1 1 Lysine-specific metallo-endopeptidase Sporozoite_P67 PF05642.11 EXF81259.1 - 0.16 10.0 0.0 0.2 9.7 0.0 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Glyco_transf_28 PF03033.20 EXF81260.1 - 6.7e-22 78.0 0.0 1.6e-21 76.8 0.0 1.7 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain Glyco_tran_28_C PF04101.16 EXF81260.1 - 0.0015 18.6 0.0 0.0026 17.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain UDPGT PF00201.18 EXF81260.1 - 0.0098 14.7 0.0 0.016 14.1 0.0 1.2 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase ATG_C PF09333.11 EXF81260.1 - 0.093 13.1 0.0 0.52 10.7 0.0 2.2 2 0 0 2 2 2 0 Autophagy-related protein C terminal domain baeRF_family3 PF18845.1 EXF81260.1 - 0.17 12.2 0.1 13 6.0 0.0 2.3 2 0 0 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 3 LRR_4 PF12799.7 EXF81261.1 - 0.014 15.8 0.2 2.2 8.8 0.0 4.0 4 0 0 4 4 4 0 Leucine Rich repeats (2 copies) Lipase_GDSL_2 PF13472.6 EXF81262.1 - 2e-14 54.4 0.2 4.3e-13 50.0 0.1 2.3 2 0 0 2 2 2 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EXF81262.1 - 2.6e-07 30.8 0.1 8.2e-07 29.2 0.1 1.9 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase FPN1 PF06963.12 EXF81263.1 - 0.18 10.4 0.0 0.23 10.0 0.0 1.1 1 0 0 1 1 1 0 Ferroportin1 (FPN1) zf-C2H2_2 PF12756.7 EXF81265.1 - 2.7e-26 91.9 6.9 1.7e-25 89.2 1.7 2.4 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) CD99L2 PF12301.8 EXF81265.1 - 0.05 13.9 1.1 0.094 13.0 1.1 1.4 1 0 0 1 1 1 0 CD99 antigen like protein 2 zf-C2H2_jaz PF12171.8 EXF81265.1 - 0.27 11.6 7.3 1.5 9.2 0.2 3.5 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.26 EXF81265.1 - 9.9 6.8 11.7 11 6.8 1.4 3.6 3 0 0 3 3 3 0 Zinc finger, C2H2 type ProRS-C_1 PF09180.11 EXF81266.1 - 7.1e-22 77.4 0.2 1.5e-21 76.4 0.2 1.6 1 0 0 1 1 1 1 Prolyl-tRNA synthetase, C-terminal tRNA-synt_2b PF00587.25 EXF81266.1 - 1.5e-20 73.9 0.0 3e-20 72.9 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 EXF81266.1 - 1.5e-17 63.6 0.0 3.7e-17 62.2 0.0 1.8 1 0 0 1 1 1 1 Anticodon binding domain DUF3123 PF11321.8 EXF81266.1 - 0.56 10.9 4.0 1.1 9.9 4.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3123) MT0933_antitox PF14013.6 EXF81266.1 - 2.3 8.6 9.9 1.6 9.1 7.2 2.1 2 0 0 2 2 2 0 MT0933-like antitoxin protein Cpn60_TCP1 PF00118.24 EXF81267.1 - 1.4e-153 512.1 13.7 1.6e-153 511.9 13.7 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Acetyltransf_7 PF13508.7 EXF81268.1 - 2.9e-07 30.8 0.0 7e-07 29.6 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EXF81268.1 - 0.0016 18.4 0.0 0.086 12.8 0.0 2.6 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EXF81268.1 - 0.0024 18.1 0.1 0.095 12.9 0.0 2.4 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_9 PF13527.7 EXF81268.1 - 0.09 12.9 0.1 0.48 10.5 0.0 2.1 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Ank_2 PF12796.7 EXF81269.1 - 1.2e-45 154.0 3.8 1.2e-13 51.4 0.1 4.0 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EXF81269.1 - 1.1e-36 124.7 6.7 4.1e-10 40.0 0.0 6.2 1 1 7 8 8 8 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 EXF81269.1 - 8.4e-28 93.4 1.7 0.0016 18.8 0.0 7.2 7 0 0 7 7 7 6 Ankyrin repeat Ank PF00023.30 EXF81269.1 - 3.1e-25 87.4 19.4 0.00065 20.0 0.2 7.5 7 1 0 7 7 7 7 Ankyrin repeat Ank_5 PF13857.6 EXF81269.1 - 5.6e-13 48.8 10.2 0.0029 17.9 0.1 6.4 1 1 6 7 7 7 6 Ankyrin repeats (many copies) TAXi_C PF14541.6 EXF81269.1 - 0.12 12.1 0.0 12 5.6 0.0 2.3 2 0 0 2 2 2 0 Xylanase inhibitor C-terminal HTH_32 PF13565.6 EXF81270.1 - 0.009 16.6 0.1 0.016 15.8 0.0 1.4 1 1 1 2 2 2 1 Homeodomain-like domain WD40 PF00400.32 EXF81271.1 - 5.3e-23 80.9 15.6 3.9e-07 30.7 0.1 5.7 5 0 0 5 5 5 5 WD domain, G-beta repeat Ge1_WD40 PF16529.5 EXF81271.1 - 0.0015 17.6 2.4 0.4 9.6 0.1 2.8 1 1 1 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 EXF81271.1 - 0.0053 17.0 0.2 0.17 12.2 0.0 2.8 3 1 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EXF81271.1 - 0.027 13.1 6.2 0.26 9.9 0.3 3.1 1 1 2 3 3 3 0 Nucleoporin Nup120/160 HET PF06985.11 EXF81272.1 - 7.6e-32 110.7 0.0 1.4e-31 109.8 0.0 1.5 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) TFIIA PF03153.13 EXF81272.1 - 2.2 8.2 6.9 3.3 7.6 6.9 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Rieske PF00355.26 EXF81274.1 - 1.7e-10 40.7 0.0 3.1e-10 39.9 0.0 1.4 1 1 0 1 1 1 1 Rieske [2Fe-2S] domain UCR_TM PF02921.14 EXF81274.1 - 1.5e-08 35.0 3.5 1.7e-08 34.8 1.1 2.4 3 1 0 3 3 3 1 Ubiquinol cytochrome reductase transmembrane region MMS1_N PF10433.9 EXF81275.1 - 4.5e-117 391.7 0.0 7.3e-117 391.0 0.0 1.4 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 EXF81275.1 - 2.7e-66 224.1 0.0 1e-64 218.9 0.0 2.3 2 0 0 2 2 2 2 CPSF A subunit region Acetyltransf_1 PF00583.25 EXF81276.1 - 1.4e-09 38.2 0.0 2.6e-09 37.3 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EXF81276.1 - 3.3e-07 30.6 0.0 4.9e-07 30.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EXF81276.1 - 1.1e-06 28.6 0.0 2e-06 27.8 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EXF81276.1 - 0.0002 21.3 0.0 0.00039 20.3 0.0 1.5 1 0 0 1 1 1 1 FR47-like protein HsbA PF12296.8 EXF81277.1 - 3.4e-18 66.2 6.5 5.7e-18 65.5 6.5 1.4 1 0 0 1 1 1 1 Hydrophobic surface binding protein A p450 PF00067.22 EXF81278.1 - 8.3e-53 179.8 0.0 1.2e-52 179.2 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 Polyketide_cyc2 PF10604.9 EXF81279.1 - 0.00039 20.7 0.0 0.00044 20.5 0.0 1.2 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport SET PF00856.28 EXF81280.1 - 7.7e-14 52.4 0.3 3.5e-13 50.3 0.0 2.1 2 1 0 2 2 2 1 SET domain Fungal_trans PF04082.18 EXF81283.1 - 1.1e-15 57.3 0.0 2.2e-15 56.4 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF81283.1 - 2.2e-07 30.8 5.8 3.7e-07 30.1 5.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain p450 PF00067.22 EXF81284.1 - 2.5e-62 211.1 0.0 4.3e-62 210.4 0.0 1.3 1 1 0 1 1 1 1 Cytochrome P450 AA_permease_2 PF13520.6 EXF81285.1 - 6e-59 200.0 47.8 7.5e-59 199.7 47.8 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EXF81285.1 - 8.1e-21 74.2 40.4 1.1e-20 73.8 40.4 1.0 1 0 0 1 1 1 1 Amino acid permease HgmA PF04209.13 EXF81286.1 - 5.9e-199 661.1 0.0 6.7e-199 660.9 0.0 1.0 1 0 0 1 1 1 1 homogentisate 1,2-dioxygenase FAA_hydrolase PF01557.18 EXF81287.1 - 4.5e-57 193.2 0.0 6.2e-57 192.8 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family FAA_hydrolase_N PF09298.11 EXF81287.1 - 1.7e-32 111.7 0.0 3.3e-32 110.8 0.0 1.5 1 0 0 1 1 1 1 Fumarylacetoacetase N-terminal Dabb PF07876.12 EXF81288.1 - 1.3e-14 54.6 0.0 1.6e-14 54.3 0.0 1.1 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain DUF4123 PF13503.6 EXF81288.1 - 0.04 14.4 0.0 0.044 14.2 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4123) Hormone_3 PF00159.18 EXF81289.1 - 0.057 13.5 0.2 0.11 12.6 0.2 1.5 1 0 0 1 1 1 0 Pancreatic hormone peptide HET PF06985.11 EXF81291.1 - 2.7e-37 128.4 0.1 8.5e-37 126.7 0.1 1.8 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) CAP160 PF07918.11 EXF81291.1 - 0.13 12.0 0.1 0.24 11.2 0.1 1.4 1 0 0 1 1 1 0 CAP160 repeat CMAS PF02353.20 EXF81292.1 - 5.1e-61 206.4 0.2 6.3e-61 206.1 0.2 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_11 PF08241.12 EXF81292.1 - 1.9e-07 31.6 0.0 3.5e-07 30.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EXF81292.1 - 2.8e-07 30.5 0.0 4.4e-07 29.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF81292.1 - 1.3e-06 29.1 0.0 2.6e-06 28.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain DOT1 PF08123.13 EXF81292.1 - 0.018 14.6 0.0 0.032 13.7 0.0 1.3 1 0 0 1 1 1 0 Histone methylation protein DOT1 PCMT PF01135.19 EXF81292.1 - 0.025 14.3 0.0 0.042 13.6 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.14 EXF81292.1 - 0.027 14.0 0.0 0.055 13.0 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase small domain Adeno_E3_CR2 PF02439.15 EXF81293.1 - 0.19 11.5 1.5 0.43 10.4 1.5 1.5 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Apc13p PF05839.11 EXF81294.1 - 3.9e-31 107.1 0.1 4.5e-31 106.9 0.1 1.1 1 0 0 1 1 1 1 Apc13p protein TRAPP PF04051.16 EXF81295.1 - 8.3e-42 142.3 0.0 9.9e-42 142.1 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component CRAL_TRIO PF00650.20 EXF81296.1 - 8.1e-41 139.4 0.0 1.2e-40 138.9 0.0 1.1 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EXF81296.1 - 3.7e-14 52.7 1.2 3.7e-14 52.7 1.2 1.6 2 0 0 2 2 2 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 EXF81296.1 - 0.012 15.8 0.0 0.017 15.2 0.0 1.2 1 0 0 1 1 1 0 Divergent CRAL/TRIO domain DUF3328 PF11807.8 EXF81298.1 - 3.1e-20 72.9 1.2 4.6e-20 72.4 1.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) Orbi_VP3 PF01700.16 EXF81300.1 - 0.14 10.1 0.0 0.2 9.5 0.0 1.1 1 0 0 1 1 1 0 Orbivirus VP3 (T2) protein S19 PF06756.11 EXF81301.1 - 0.15 12.0 0.0 0.32 11.0 0.0 1.5 1 0 0 1 1 1 0 Chorion protein S19 C-terminal Zincin_2 PF10103.9 EXF81301.1 - 0.39 9.9 3.2 1.2 8.3 3.1 1.7 1 1 0 1 1 1 0 Zincin-like metallopeptidase SKG6 PF08693.10 EXF81302.1 - 0.0024 17.3 0.6 0.0048 16.3 0.6 1.5 1 0 0 1 1 1 1 Transmembrane alpha-helix domain DUF4448 PF14610.6 EXF81302.1 - 0.076 12.8 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) LapA_dom PF06305.11 EXF81302.1 - 0.1 12.4 0.1 0.19 11.6 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain HET PF06985.11 EXF81303.1 - 7.1e-28 97.8 0.0 1.2e-27 97.0 0.0 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Lipase_GDSL_2 PF13472.6 EXF81304.1 - 1.5e-15 58.1 0.0 2e-15 57.7 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EXF81304.1 - 2.9e-10 40.5 0.0 6.6e-10 39.3 0.0 1.6 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase OSK PF17182.4 EXF81304.1 - 3.2e-05 23.2 0.0 4.4e-05 22.8 0.0 1.1 1 0 0 1 1 1 1 OSK domain Lipase_GDSL_3 PF14606.6 EXF81304.1 - 0.11 12.6 0.0 0.15 12.2 0.0 1.1 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family Cellulase PF00150.18 EXF81305.1 - 1.1e-19 71.0 0.5 1.4e-19 70.6 0.5 1.1 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_2_C PF02836.17 EXF81305.1 - 7.6e-08 31.8 0.0 1.2e-07 31.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_42 PF02449.15 EXF81305.1 - 0.0001 21.8 0.1 0.00026 20.5 0.1 1.6 1 0 0 1 1 1 1 Beta-galactosidase DUF4038 PF13204.6 EXF81305.1 - 0.002 17.8 3.2 0.0052 16.5 3.4 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF4038) Gpr1_Fun34_YaaH PF01184.19 EXF81307.1 - 1e-26 93.8 6.5 1.2e-26 93.7 6.5 1.1 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family Ammonium_transp PF00909.21 EXF81308.1 - 1.5e-98 330.1 19.3 1.9e-98 329.8 19.3 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family Comm PF15957.5 EXF81308.1 - 0.44 10.9 1.6 0.52 10.7 0.0 1.9 2 0 0 2 2 2 0 Commissureless DUF3445 PF11927.8 EXF81309.1 - 2.1e-72 243.4 0.0 2.7e-72 243.0 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3445) Fungal_trans_2 PF11951.8 EXF81310.1 - 1.6e-26 93.0 1.6 1.6e-19 70.0 1.0 2.1 2 0 0 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF81310.1 - 5.4e-08 32.8 7.2 8.3e-08 32.2 7.2 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain EutQ PF06249.12 EXF81311.1 - 1.5e-12 47.5 0.0 2e-12 47.1 0.0 1.0 1 0 0 1 1 1 1 Ethanolamine utilisation protein EutQ Cupin_3 PF05899.12 EXF81311.1 - 9.3e-10 38.1 0.0 2.6e-09 36.6 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF861) Cupin_2 PF07883.11 EXF81311.1 - 7.2e-05 22.4 0.0 0.0001 21.9 0.0 1.3 1 0 0 1 1 1 1 Cupin domain KduI PF04962.12 EXF81311.1 - 0.046 13.0 0.0 0.051 12.9 0.0 1.1 1 0 0 1 1 1 0 KduI/IolB family Pirin PF02678.16 EXF81311.1 - 0.053 13.5 0.0 0.065 13.2 0.0 1.3 1 0 0 1 1 1 0 Pirin Cupin_1 PF00190.22 EXF81311.1 - 0.1 12.2 0.0 0.12 12.0 0.0 1.2 1 0 0 1 1 1 0 Cupin Cupin_6 PF12852.7 EXF81311.1 - 0.14 11.9 0.0 0.16 11.6 0.0 1.1 1 0 0 1 1 1 0 Cupin DUF3445 PF11927.8 EXF81312.1 - 2.5e-78 262.8 0.0 3.2e-78 262.4 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3445) DOPA_dioxygen PF08883.11 EXF81313.1 - 2.6e-30 104.7 0.0 5e-30 103.8 0.0 1.5 1 0 0 1 1 1 1 Dopa 4,5-dioxygenase family DUF3328 PF11807.8 EXF81313.1 - 6.7e-22 78.3 0.5 1.1e-21 77.7 0.5 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) Tmemb_161AB PF10268.9 EXF81313.1 - 0.044 12.4 0.2 0.062 11.9 0.2 1.1 1 0 0 1 1 1 0 Predicted transmembrane protein 161AB TAP35_44 PF07265.11 EXF81314.1 - 0.0076 16.3 1.0 41 4.2 0.0 4.0 1 1 5 6 6 6 5 Tapetum specific protein TAP35/TAP44 DinB_2 PF12867.7 EXF81315.1 - 0.0006 20.3 0.3 0.00099 19.6 0.3 1.4 1 0 0 1 1 1 1 DinB superfamily HET PF06985.11 EXF81316.1 - 2.1e-10 41.1 7.0 6.9e-08 33.0 0.9 3.1 2 1 1 3 3 3 2 Heterokaryon incompatibility protein (HET) DUF2541 PF10807.8 EXF81316.1 - 0.16 12.1 0.0 0.29 11.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2541) dCMP_cyt_deam_1 PF00383.23 EXF81317.1 - 2.1e-08 34.0 0.1 4.4e-08 32.9 0.1 1.5 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EXF81317.1 - 0.00076 19.2 0.4 0.0047 16.7 0.0 2.3 2 1 0 2 2 2 1 MafB19-like deaminase GST_N_3 PF13417.6 EXF81318.1 - 2.7e-14 53.3 0.0 5e-14 52.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EXF81318.1 - 1.3e-13 51.0 0.0 2.5e-13 50.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 EXF81318.1 - 1.2e-12 48.0 0.0 5.9e-12 45.8 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain Glutaredoxin PF00462.24 EXF81318.1 - 0.002 18.3 0.0 0.0042 17.3 0.0 1.6 1 0 0 1 1 1 1 Glutaredoxin GST_C PF00043.25 EXF81318.1 - 0.014 15.6 0.1 0.034 14.4 0.1 1.6 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain TPP_enzyme_N PF02776.18 EXF81319.1 - 1.9e-45 154.5 1.6 3.1e-45 153.9 0.7 1.7 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 EXF81319.1 - 8.5e-41 139.3 0.2 4.3e-39 133.8 0.0 2.4 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 EXF81319.1 - 6.5e-26 90.7 0.0 1.5e-25 89.6 0.0 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain Peptidase_M55 PF04951.13 EXF81319.1 - 0.015 14.7 0.1 0.034 13.6 0.1 1.5 1 0 0 1 1 1 0 D-aminopeptidase AAL_decarboxy PF03306.13 EXF81320.1 - 3e-78 262.1 0.1 3.4e-78 261.9 0.1 1.0 1 0 0 1 1 1 1 Alpha-acetolactate decarboxylase TPP_enzyme_N PF02776.18 EXF81322.1 - 5.1e-32 110.8 0.5 8.2e-32 110.2 0.5 1.3 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 EXF81322.1 - 2.1e-19 69.8 0.0 2.9e-17 62.9 0.0 2.5 2 0 0 2 2 2 2 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 EXF81322.1 - 2.9e-17 62.7 0.0 8.4e-17 61.2 0.0 1.8 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_M_2 PF16582.5 EXF81322.1 - 0.18 11.5 0.0 0.31 10.7 0.0 1.3 1 0 0 1 1 1 0 Middle domain of thiamine pyrophosphate NUDIX PF00293.28 EXF81323.1 - 3.2e-07 30.4 0.0 5.9e-07 29.6 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain Fungal_trans_2 PF11951.8 EXF81323.1 - 2.7e-06 26.5 1.3 4.4e-06 25.8 1.3 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF81323.1 - 4.9e-06 26.5 8.9 1e-05 25.6 8.9 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF4743 PF15916.5 EXF81323.1 - 0.042 13.8 0.0 0.084 12.8 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4743) FAD_binding_4 PF01565.23 EXF81324.1 - 3.7e-19 68.8 1.8 6.3e-19 68.1 1.8 1.4 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EXF81324.1 - 1.3e-07 31.5 0.2 3.1e-07 30.4 0.2 1.6 1 0 0 1 1 1 1 Berberine and berberine like Citrate_bind PF16114.5 EXF81324.1 - 0.12 11.8 0.0 2.3 7.7 0.0 2.4 2 0 0 2 2 2 0 ATP citrate lyase citrate-binding p450 PF00067.22 EXF81325.1 - 2.7e-54 184.6 0.0 3.3e-54 184.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Pectate_lyase_3 PF12708.7 EXF81326.1 - 4.1e-89 298.1 6.5 3.7e-73 245.9 0.0 2.8 3 0 0 3 3 3 2 Pectate lyase superfamily protein LysM PF01476.20 EXF81326.1 - 4.1e-08 33.2 0.0 2.6e-05 24.2 0.0 3.0 3 0 0 3 3 3 2 LysM domain End_N_terminal PF12218.8 EXF81326.1 - 5.2e-07 29.3 3.8 0.014 15.1 0.3 2.7 2 0 0 2 2 2 2 N terminal extension of bacteriophage endosialidase Glyco_hydro_18 PF00704.28 EXF81327.1 - 6.9e-68 229.7 0.3 6.9e-68 229.7 0.3 1.7 2 0 0 2 2 2 1 Glycosyl hydrolases family 18 Chitin_bind_1 PF00187.19 EXF81327.1 - 4.9e-10 39.7 7.0 4.9e-10 39.7 7.0 6.6 10 1 0 10 10 10 2 Chitin recognition protein FAD_binding_3 PF01494.19 EXF81329.1 - 7.3e-33 114.3 0.1 1.2e-32 113.5 0.1 1.4 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.6 EXF81329.1 - 3.9e-07 29.6 0.4 1.6e-06 27.6 0.3 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EXF81329.1 - 2e-06 27.9 0.5 1.6e-05 25.0 0.2 2.3 1 1 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 EXF81329.1 - 1.2e-05 24.8 0.0 0.072 12.4 0.0 2.6 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase Pyr_redox_2 PF07992.14 EXF81329.1 - 4.9e-05 22.7 2.0 0.00058 19.2 0.3 2.1 1 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EXF81329.1 - 0.00033 21.1 0.8 0.0021 18.6 0.5 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EXF81329.1 - 0.00037 19.7 0.3 0.00074 18.7 0.3 1.4 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 EXF81329.1 - 0.00041 19.7 0.5 0.00067 19.0 0.5 1.4 1 1 0 1 1 1 1 Thi4 family HI0933_like PF03486.14 EXF81329.1 - 0.00045 19.0 0.3 0.0013 17.5 0.1 1.8 2 0 0 2 2 2 1 HI0933-like protein FAD_oxidored PF12831.7 EXF81329.1 - 0.0021 17.5 0.3 0.0021 17.5 0.3 1.8 2 1 0 2 2 2 1 FAD dependent oxidoreductase Trp_halogenase PF04820.14 EXF81329.1 - 0.0021 17.0 0.7 0.0051 15.7 0.2 1.8 2 0 0 2 2 2 1 Tryptophan halogenase Lycopene_cycl PF05834.12 EXF81329.1 - 0.0026 16.9 1.9 0.011 14.8 0.9 2.2 2 1 0 2 2 2 1 Lycopene cyclase protein DAO PF01266.24 EXF81329.1 - 0.0044 16.6 2.6 0.024 14.2 1.5 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase GIDA PF01134.22 EXF81329.1 - 0.021 13.9 1.9 0.057 12.5 1.8 1.9 2 1 0 2 2 2 0 Glucose inhibited division protein A TrkA_N PF02254.18 EXF81329.1 - 0.032 14.5 0.1 0.084 13.1 0.1 1.7 1 0 0 1 1 1 0 TrkA-N domain AlaDh_PNT_C PF01262.21 EXF81329.1 - 0.062 12.6 0.1 0.1 11.9 0.1 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_9 PF13454.6 EXF81329.1 - 0.22 11.5 2.4 2.3 8.2 0.3 2.9 3 0 0 3 3 3 0 FAD-NAD(P)-binding Spherulin4 PF12138.8 EXF81330.1 - 8.7e-41 140.1 3.1 1e-40 139.9 3.1 1.0 1 0 0 1 1 1 1 Spherulation-specific family 4 Acetyltransf_10 PF13673.7 EXF81331.1 - 4.4e-05 23.4 0.0 7.8e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EXF81331.1 - 7.6e-05 22.9 0.1 0.00016 21.9 0.1 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EXF81331.1 - 0.00014 22.2 0.1 0.00025 21.4 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EXF81331.1 - 0.0066 16.5 0.0 0.027 14.6 0.0 1.9 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain SGL PF08450.12 EXF81334.1 - 4.7e-08 32.9 0.2 2.4e-07 30.6 0.2 1.9 1 1 1 2 2 2 1 SMP-30/Gluconolactonase/LRE-like region PQQ_3 PF13570.6 EXF81334.1 - 0.34 11.5 5.1 20 5.9 2.5 4.2 2 2 0 2 2 2 0 PQQ-like domain PEP_mutase PF13714.6 EXF81335.1 - 2.8e-59 200.5 0.5 3.1e-59 200.3 0.5 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase FAD_binding_4 PF01565.23 EXF81336.1 - 6.1e-19 68.1 0.2 9.8e-19 67.5 0.2 1.3 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EXF81336.1 - 5.1e-13 48.9 0.0 1.1e-12 47.8 0.0 1.6 1 0 0 1 1 1 1 Berberine and berberine like Sugar_tr PF00083.24 EXF81338.1 - 1.3e-42 146.2 8.6 1.6e-42 146.0 8.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_2 PF13347.6 EXF81338.1 - 0.00035 19.3 8.3 0.00035 19.3 8.3 1.4 1 1 0 1 1 1 1 MFS/sugar transport protein Methyltransf_23 PF13489.6 EXF81339.1 - 2.1e-21 76.4 0.0 3e-21 75.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF81339.1 - 3e-10 40.1 0.0 0.00023 21.0 0.0 2.1 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_25 PF13649.6 EXF81339.1 - 7.6e-10 39.4 0.0 1.7e-09 38.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF81339.1 - 4.6e-09 36.9 0.1 3.2e-08 34.2 0.1 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF81339.1 - 2.1e-07 31.5 0.0 3.7e-07 30.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EXF81339.1 - 0.0016 17.8 0.0 0.099 12.0 0.0 2.8 2 1 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_2 PF00891.18 EXF81339.1 - 0.0026 17.1 0.0 0.0045 16.3 0.0 1.4 1 0 0 1 1 1 1 O-methyltransferase domain FtsJ PF01728.19 EXF81339.1 - 0.0067 16.6 0.0 0.0095 16.1 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase MTS PF05175.14 EXF81339.1 - 0.0088 15.6 0.0 0.016 14.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_16 PF10294.9 EXF81339.1 - 0.038 13.7 0.0 0.098 12.4 0.0 1.8 1 1 0 1 1 1 0 Lysine methyltransferase CMD PF02627.20 EXF81342.1 - 0.0066 16.5 0.0 0.022 14.8 0.0 1.9 2 0 0 2 2 2 1 Carboxymuconolactone decarboxylase family Glyco_hydro_2_C PF02836.17 EXF81343.1 - 6.1e-90 301.4 0.0 1.7e-89 299.9 0.0 1.6 2 0 0 2 2 2 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_2_N PF02837.18 EXF81343.1 - 1.3e-26 93.5 0.0 2.6e-26 92.6 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2 PF00703.21 EXF81343.1 - 5.3e-13 49.6 0.5 2.6e-12 47.4 0.2 2.1 2 0 0 2 2 2 1 Glycosyl hydrolases family 2 Cellulase PF00150.18 EXF81343.1 - 0.021 14.3 0.0 0.15 11.5 0.0 2.1 1 1 0 1 1 1 0 Cellulase (glycosyl hydrolase family 5) p450 PF00067.22 EXF81344.1 - 1.1e-43 149.7 0.0 2.8e-29 102.2 0.0 2.7 2 1 0 2 2 2 2 Cytochrome P450 MCR_beta PF02241.18 EXF81344.1 - 0.067 12.8 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 Methyl-coenzyme M reductase beta subunit, C-terminal domain DUF2396 PF09654.10 EXF81344.1 - 0.12 12.5 0.6 0.2 11.8 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2396) CorA PF01544.18 EXF81345.1 - 0.00074 18.9 3.1 0.0018 17.6 3.1 1.7 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein TMEM208_SND2 PF05620.11 EXF81345.1 - 0.11 12.2 0.0 0.21 11.3 0.0 1.4 1 0 0 1 1 1 0 SRP-independent targeting protein 2/TMEM208 DUF456 PF04306.13 EXF81345.1 - 0.17 12.2 1.6 0.29 11.4 1.5 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF456) Pkinase PF00069.25 EXF81346.1 - 3.2e-10 39.8 0.0 3e-09 36.6 0.0 2.2 1 1 0 1 1 1 1 Protein kinase domain NB-ARC PF00931.22 EXF81346.1 - 6.7e-10 38.6 0.0 1.1e-09 37.8 0.0 1.2 1 0 0 1 1 1 1 NB-ARC domain AAA_16 PF13191.6 EXF81346.1 - 1.9e-05 25.1 1.4 5.9e-05 23.5 0.0 2.6 3 0 0 3 3 2 1 AAA ATPase domain ANAPC3 PF12895.7 EXF81346.1 - 0.0012 19.1 1.0 1.5 9.1 0.4 2.9 2 0 0 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 Pkinase_Tyr PF07714.17 EXF81346.1 - 0.0013 18.0 0.0 0.22 10.8 0.0 2.4 2 0 0 2 2 2 1 Protein tyrosine kinase IstB_IS21 PF01695.17 EXF81346.1 - 0.0018 18.1 0.0 0.0046 16.7 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein TPR_19 PF14559.6 EXF81346.1 - 0.0038 17.7 9.0 0.054 14.0 1.3 3.3 1 1 3 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 EXF81346.1 - 0.0053 17.0 11.1 1.5 9.2 0.1 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat ResIII PF04851.15 EXF81346.1 - 0.015 15.3 0.0 0.027 14.5 0.0 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit TPR_8 PF13181.6 EXF81346.1 - 0.035 14.3 0.1 38 4.9 0.1 4.0 4 0 0 4 4 3 0 Tetratricopeptide repeat DUF3716 PF12511.8 EXF81346.1 - 0.038 14.0 0.9 0.1 12.7 0.9 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3716) Ras PF00071.22 EXF81346.1 - 0.091 12.4 0.0 0.19 11.3 0.0 1.5 1 0 0 1 1 1 0 Ras family TPR_2 PF07719.17 EXF81346.1 - 0.1 12.7 10.1 0.57 10.4 0.6 4.9 5 0 0 5 5 4 0 Tetratricopeptide repeat NACHT PF05729.12 EXF81346.1 - 0.12 12.3 0.2 0.41 10.6 0.0 2.0 2 0 0 2 2 2 0 NACHT domain Roc PF08477.13 EXF81346.1 - 0.17 12.1 0.0 0.61 10.3 0.0 2.0 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase TPR_7 PF13176.6 EXF81346.1 - 0.21 11.7 3.5 1.9 8.7 0.1 3.5 3 0 0 3 3 2 0 Tetratricopeptide repeat ArsA_ATPase PF02374.15 EXF81346.1 - 0.26 10.4 0.1 0.48 9.6 0.1 1.4 1 0 0 1 1 1 0 Anion-transporting ATPase TPR_10 PF13374.6 EXF81346.1 - 0.55 10.2 6.7 3.7 7.6 0.2 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat CMD PF02627.20 EXF81347.1 - 0.078 13.0 0.0 0.19 11.8 0.0 1.7 1 0 0 1 1 1 0 Carboxymuconolactone decarboxylase family PIF1 PF05970.14 EXF81348.1 - 4.4e-39 134.7 2.4 6.8e-27 94.6 0.0 3.6 2 1 1 3 3 3 3 PIF1-like helicase AAA_30 PF13604.6 EXF81348.1 - 5.3e-22 78.5 0.1 9.1e-16 58.1 0.0 3.2 3 0 0 3 3 3 2 AAA domain AAA_19 PF13245.6 EXF81348.1 - 5.4e-12 46.3 0.0 2.7e-11 44.0 0.0 2.2 2 1 0 2 2 2 1 AAA domain AAA_5 PF07728.14 EXF81348.1 - 3.8e-06 26.9 0.0 7.6e-06 26.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Viral_helicase1 PF01443.18 EXF81348.1 - 5.8e-06 26.2 0.6 0.13 11.9 0.3 3.1 2 1 0 2 2 2 2 Viral (Superfamily 1) RNA helicase Herpes_Helicase PF02689.14 EXF81348.1 - 2e-05 22.7 0.2 0.00089 17.3 0.0 2.2 2 0 0 2 2 2 1 Helicase AAA_22 PF13401.6 EXF81348.1 - 3.1e-05 24.3 0.0 6.6e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain Cauli_VI PF01693.16 EXF81348.1 - 0.0002 21.6 0.7 0.0011 19.3 0.3 2.5 2 0 0 2 2 1 1 Caulimovirus viroplasmin AAA_16 PF13191.6 EXF81348.1 - 0.00022 21.7 0.0 0.00045 20.6 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain UvrD_C_2 PF13538.6 EXF81348.1 - 0.00039 20.2 0.0 0.0039 17.0 0.0 2.3 2 0 0 2 2 2 1 UvrD-like helicase C-terminal domain RNA_helicase PF00910.22 EXF81348.1 - 0.00064 20.1 0.1 0.016 15.6 0.1 2.6 1 1 0 1 1 1 1 RNA helicase Mg_chelatase PF01078.21 EXF81348.1 - 0.0012 18.2 0.0 0.0022 17.4 0.0 1.3 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_29 PF13555.6 EXF81348.1 - 0.0036 17.0 0.1 0.0078 15.9 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_tran PF00005.27 EXF81348.1 - 0.0062 17.0 0.5 0.02 15.4 0.0 2.1 2 0 0 2 2 1 1 ABC transporter Rad17 PF03215.15 EXF81348.1 - 0.016 15.1 0.0 0.039 13.9 0.0 1.6 1 0 0 1 1 1 0 Rad17 P-loop domain Helicase_RecD PF05127.14 EXF81348.1 - 0.021 14.7 0.2 0.1 12.4 0.1 2.3 2 1 0 2 2 2 0 Helicase AAA PF00004.29 EXF81348.1 - 0.021 15.2 0.0 0.042 14.3 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 EXF81348.1 - 0.032 14.3 0.0 0.093 12.8 0.0 1.8 1 1 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 EXF81348.1 - 0.046 13.4 0.7 7.2 6.3 0.2 2.3 1 1 0 2 2 2 0 IstB-like ATP binding protein DUF815 PF05673.13 EXF81348.1 - 0.065 12.4 0.1 0.12 11.6 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) DUF2075 PF09848.9 EXF81348.1 - 0.067 12.4 0.0 0.14 11.4 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) NTPase_1 PF03266.15 EXF81348.1 - 0.12 12.3 0.6 10 6.0 0.1 2.3 2 0 0 2 2 2 0 NTPase AAA_28 PF13521.6 EXF81348.1 - 0.12 12.6 0.0 0.24 11.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 EXF81348.1 - 0.15 11.2 0.1 0.26 10.4 0.1 1.3 1 0 0 1 1 1 0 NB-ARC domain ATP-synt_ab PF00006.25 EXF81348.1 - 0.16 11.6 0.0 0.18 11.4 0.0 1.3 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain Ldt_C PF17969.1 EXF81348.1 - 0.63 10.8 4.5 14 6.5 0.0 4.1 3 1 1 4 4 4 0 L,D-transpeptidase C-terminal domain CDC45 PF02724.14 EXF81348.1 - 5.5 5.1 9.0 9.3 4.4 9.0 1.2 1 0 0 1 1 1 0 CDC45-like protein FAD_binding_4 PF01565.23 EXF81350.1 - 1.5e-24 86.3 6.4 3.2e-24 85.2 5.9 1.9 2 0 0 2 2 2 1 FAD binding domain BBE PF08031.12 EXF81350.1 - 3e-11 43.2 0.1 5.7e-11 42.3 0.1 1.5 1 0 0 1 1 1 1 Berberine and berberine like Rootletin PF15035.6 EXF81351.1 - 0.001 19.1 0.9 0.0017 18.4 0.9 1.2 1 0 0 1 1 1 1 Ciliary rootlet component, centrosome cohesion YabA PF06156.13 EXF81351.1 - 0.096 13.3 0.1 0.18 12.4 0.1 1.5 1 0 0 1 1 1 0 Initiation control protein YabA ATF7IP_BD PF16788.5 EXF81351.1 - 0.2 11.7 2.4 0.11 12.6 0.4 1.6 2 1 0 2 2 2 0 ATF-interacting protein binding domain CFEM PF05730.11 EXF81352.1 - 1.1e-06 28.7 7.6 2e-06 27.8 7.6 1.4 1 0 0 1 1 1 1 CFEM domain TFR_dimer PF04253.15 EXF81353.1 - 3.9e-25 88.3 0.0 6.7e-25 87.5 0.0 1.4 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.17 EXF81353.1 - 1e-20 74.3 0.0 1.8e-20 73.5 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 EXF81353.1 - 4.5e-08 33.0 0.5 3.7e-07 30.1 0.5 2.3 1 1 0 1 1 1 1 PA domain Peptidase_M13_N PF05649.13 EXF81354.1 - 9.2e-98 328.4 0.0 1.4e-97 327.8 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M13 Peptidase_M13 PF01431.21 EXF81354.1 - 4.5e-62 209.3 1.2 1.5e-61 207.6 0.2 2.0 2 0 0 2 2 2 1 Peptidase family M13 SLAC1 PF03595.17 EXF81355.1 - 2.3e-85 286.8 38.1 2.6e-85 286.5 38.1 1.0 1 0 0 1 1 1 1 Voltage-dependent anion channel HET PF06985.11 EXF81356.1 - 1.2e-35 123.0 0.3 2e-35 122.3 0.3 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Saf-Nte_pilin PF09460.10 EXF81356.1 - 0.078 13.0 0.2 12 5.9 0.0 2.2 2 0 0 2 2 2 0 Saf-pilin pilus formation protein CTP_transf_like PF01467.26 EXF81357.1 - 1.6e-07 31.6 0.2 0.00028 21.1 0.0 2.5 2 1 0 2 2 2 2 Cytidylyltransferase-like FAD_syn PF06574.12 EXF81357.1 - 0.14 12.0 0.0 0.26 11.1 0.0 1.4 1 0 0 1 1 1 0 FAD synthetase NMT1 PF09084.11 EXF81358.1 - 0.00015 21.7 0.0 0.00031 20.7 0.0 1.6 1 1 0 1 1 1 1 NMT1/THI5 like SBP_bac_3 PF00497.20 EXF81358.1 - 0.0017 17.8 0.0 0.01 15.3 0.0 2.1 1 1 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 TOPRIM_C PF16898.5 EXF81358.1 - 0.087 13.1 0.1 0.12 12.6 0.1 1.3 1 0 0 1 1 1 0 C-terminal associated domain of TOPRIM GCD14 PF08704.10 EXF81359.1 - 2.2e-61 207.7 0.0 7e-60 202.8 0.0 2.2 1 1 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit tRNA-synt_1e PF01406.19 EXF81360.1 - 6.1e-112 373.9 0.1 9e-112 373.3 0.1 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.11 EXF81360.1 - 2.2e-06 26.7 0.6 0.031 13.0 0.1 2.4 2 0 0 2 2 2 2 tRNA synthetases class I (M) DALR_2 PF09190.11 EXF81360.1 - 0.0061 17.0 0.1 0.0061 17.0 0.1 2.3 2 0 0 2 2 2 1 DALR domain DUF1599 PF07659.11 EXF81360.1 - 0.085 13.3 0.1 0.3 11.6 0.1 1.9 1 0 0 1 1 1 0 Nucleotide modification associated domain 1 tRNA-synt_1c PF00749.21 EXF81360.1 - 0.15 10.9 1.0 0.28 10.1 0.0 1.8 2 0 0 2 2 2 0 tRNA synthetases class I (E and Q), catalytic domain NARP1 PF12569.8 EXF81360.1 - 0.21 10.4 8.0 10 4.9 8.3 2.3 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 DUF3759 PF12585.8 EXF81361.1 - 5.8e-41 138.4 7.0 7.7e-41 138.0 7.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3759) ARHGEF5_35 PF15441.6 EXF81361.1 - 0.033 13.2 3.0 0.038 13.0 3.0 1.0 1 0 0 1 1 1 0 Rho guanine nucleotide exchange factor 5/35 MAP7 PF05672.11 EXF81361.1 - 0.056 13.1 4.4 0.064 12.9 4.4 1.1 1 0 0 1 1 1 0 MAP7 (E-MAP-115) family DUF3824 PF12868.7 EXF81361.1 - 0.2 12.3 3.8 1.7 9.3 3.8 2.0 1 1 0 1 1 1 0 Domain of unknwon function (DUF3824) DUF3818 PF12825.7 EXF81362.1 - 0.18 10.8 7.9 0.064 12.3 4.5 1.8 2 0 0 2 2 2 0 Domain of unknown function in PX-proteins (DUF3818) CheD PF03975.13 EXF81362.1 - 0.21 11.7 1.5 1.4 9.0 0.4 2.5 3 0 0 3 3 3 0 CheD chemotactic sensory transduction WDCP PF15390.6 EXF81362.1 - 2.7 6.3 6.7 2.3 6.5 5.4 1.5 1 1 0 1 1 1 0 WD repeat and coiled-coil-containing protein family SMBP PF16785.5 EXF81362.1 - 3.6 7.8 8.1 0.36 11.0 0.4 2.7 2 1 1 3 3 3 0 Small metal-binding protein MFS_1 PF07690.16 EXF81363.1 - 2e-29 102.6 30.0 3.1e-20 72.4 15.6 2.9 1 1 1 3 3 3 2 Major Facilitator Superfamily PUCC PF03209.15 EXF81363.1 - 0.0013 17.8 4.0 0.0013 17.8 4.0 2.1 2 1 0 2 2 2 1 PUCC protein DUF389 PF04087.14 EXF81363.1 - 0.018 15.1 0.4 1.7 8.7 0.0 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF389) GMC_oxred_N PF00732.19 EXF81365.1 - 1.8e-53 181.9 0.0 2.6e-53 181.3 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EXF81365.1 - 1.2e-05 25.9 0.0 1.8e-05 25.3 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase Lycopene_cycl PF05834.12 EXF81365.1 - 0.00013 21.1 0.2 0.00031 19.9 0.2 1.6 1 1 0 1 1 1 1 Lycopene cyclase protein NAD_binding_8 PF13450.6 EXF81365.1 - 0.014 15.7 0.0 0.037 14.3 0.0 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EXF81365.1 - 0.041 13.5 0.0 0.51 9.8 0.0 2.2 2 0 0 2 2 2 0 FAD dependent oxidoreductase GIDA PF01134.22 EXF81365.1 - 0.052 12.6 0.0 6 5.8 0.0 2.3 2 0 0 2 2 2 0 Glucose inhibited division protein A Pyr_redox_2 PF07992.14 EXF81365.1 - 0.094 11.9 0.0 0.39 9.9 0.0 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EXF81365.1 - 0.11 11.8 0.1 0.21 10.8 0.1 1.5 1 0 0 1 1 1 0 Thi4 family DAO PF01266.24 EXF81366.1 - 7.8e-32 111.2 0.0 1.6e-31 110.2 0.0 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase Amidohydro_2 PF04909.14 EXF81366.1 - 2.7e-25 89.8 0.6 4e-25 89.2 0.6 1.3 1 0 0 1 1 1 1 Amidohydrolase NAD_binding_9 PF13454.6 EXF81366.1 - 3.4e-07 30.4 0.1 0.031 14.3 0.0 2.4 2 0 0 2 2 2 2 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 EXF81366.1 - 9.8e-05 21.7 0.3 0.05 12.8 0.1 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EXF81366.1 - 0.00072 18.7 0.2 0.1 11.6 0.1 2.2 2 0 0 2 2 2 2 Lycopene cyclase protein GIDA PF01134.22 EXF81366.1 - 0.003 16.7 0.7 0.0049 16.0 0.1 1.6 2 0 0 2 2 2 1 Glucose inhibited division protein A Pyr_redox_3 PF13738.6 EXF81366.1 - 0.018 14.3 0.2 0.76 9.0 0.1 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EXF81366.1 - 0.027 13.3 0.3 1.1 8.0 0.1 2.4 3 0 0 3 3 3 0 Tryptophan halogenase NAD_binding_8 PF13450.6 EXF81366.1 - 0.037 14.2 0.1 0.13 12.5 0.1 2.0 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 EXF81366.1 - 0.043 13.1 0.0 0.084 12.1 0.0 1.4 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase Cupin_2 PF07883.11 EXF81367.1 - 3.3e-15 55.5 0.1 6e-15 54.7 0.1 1.4 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.19 EXF81367.1 - 1.6e-08 34.5 0.3 2.7e-08 33.8 0.1 1.4 2 0 0 2 2 2 1 AraC-like ligand binding domain MannoseP_isomer PF01050.18 EXF81367.1 - 0.0029 17.5 0.0 0.0036 17.2 0.0 1.2 1 0 0 1 1 1 1 Mannose-6-phosphate isomerase Cupin_1 PF00190.22 EXF81367.1 - 0.0031 17.1 0.0 0.0034 17.0 0.0 1.2 1 0 0 1 1 1 1 Cupin DMSP_lyase PF16867.5 EXF81367.1 - 0.013 15.2 0.0 0.014 15.0 0.0 1.1 1 0 0 1 1 1 0 Dimethlysulfonioproprionate lyase Cupin_3 PF05899.12 EXF81367.1 - 0.033 13.9 0.0 0.07 12.8 0.0 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF861) Cupin_7 PF12973.7 EXF81367.1 - 0.087 12.7 0.0 0.17 11.8 0.0 1.7 1 1 0 1 1 1 0 ChrR Cupin-like domain Ectoine_synth PF06339.12 EXF81367.1 - 0.13 12.5 0.0 0.16 12.1 0.0 1.1 1 0 0 1 1 1 0 Ectoine synthase CENP-C_C PF11699.8 EXF81367.1 - 0.16 12.2 0.0 0.23 11.7 0.0 1.2 1 0 0 1 1 1 0 Mif2/CENP-C like Pirin_C PF05726.13 EXF81367.1 - 0.18 12.2 0.0 0.26 11.7 0.0 1.2 1 0 0 1 1 1 0 Pirin C-terminal cupin domain Glyco_hydro_43 PF04616.14 EXF81368.1 - 7e-34 117.4 1.0 9.1e-34 117.1 1.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 Zn_clus PF00172.18 EXF81369.1 - 2.7e-10 40.2 12.9 4.8e-10 39.4 12.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EXF81369.1 - 0.00012 21.2 0.0 0.00024 20.2 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Fungal_trans PF04082.18 EXF81370.1 - 2.9e-26 92.1 0.0 4e-26 91.6 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain LDcluster4 PF18306.1 EXF81370.1 - 0.12 11.9 0.5 0.2 11.2 0.5 1.3 1 0 0 1 1 1 0 SLOG cluster4 family TT_ORF2 PF02957.15 EXF81370.1 - 0.69 10.8 3.1 14 6.6 0.2 3.1 3 0 0 3 3 3 0 TT viral ORF2 CN_hydrolase PF00795.22 EXF81371.1 - 4e-43 147.6 0.0 4.6e-43 147.4 0.0 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Dehydratase_hem PF13816.6 EXF81372.1 - 1.1e-109 366.6 0.0 1.3e-109 366.4 0.0 1.0 1 0 0 1 1 1 1 Haem-containing dehydratase DUF4188 PF13826.6 EXF81372.1 - 1.7e-07 31.6 0.1 0.0035 17.7 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF4188) Carb_anhydrase PF00194.21 EXF81374.1 - 6.2e-22 78.4 0.0 1.1e-21 77.6 0.0 1.3 1 1 0 1 1 1 1 Eukaryotic-type carbonic anhydrase MGC-24 PF05283.11 EXF81375.1 - 0.00014 22.3 1.8 0.00014 22.3 1.8 2.5 2 1 0 2 2 2 1 Multi-glycosylated core protein 24 (MGC-24), sialomucin TMEM154 PF15102.6 EXF81375.1 - 0.0039 17.1 1.1 0.0052 16.7 0.0 1.7 2 0 0 2 2 2 1 TMEM154 protein family Amnionless PF14828.6 EXF81375.1 - 0.1 11.4 0.1 0.15 10.9 0.1 1.1 1 0 0 1 1 1 0 Amnionless Syndecan PF01034.20 EXF81375.1 - 0.23 11.4 0.8 0.49 10.3 0.8 1.5 1 0 0 1 1 1 0 Syndecan domain DUF5518 PF17647.1 EXF81375.1 - 0.32 11.2 9.7 1.1 9.4 9.7 1.9 1 1 0 1 1 1 0 Family of unknown function (DUF5518) MtrF PF09472.10 EXF81375.1 - 0.34 10.3 1.3 1.4 8.4 1.3 2.0 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF) DUF4428 PF14471.6 EXF81377.1 - 0.11 12.5 0.0 0.2 11.6 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4428) Big_3_5 PF16640.5 EXF81378.1 - 0.091 13.0 10.8 0.2 11.9 10.3 1.9 1 1 0 1 1 1 0 Bacterial Ig-like domain (group 3) CHRD PF07452.12 EXF81379.1 - 1.7e-10 41.9 0.1 2.4e-10 41.4 0.1 1.2 1 0 0 1 1 1 1 CHRD domain Peptidase_S9 PF00326.21 EXF81382.1 - 2.4e-41 141.6 0.0 3.5e-41 141.0 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 EXF81382.1 - 2.7e-09 36.7 0.7 0.00055 19.3 0.5 2.2 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Peptidase_S15 PF02129.18 EXF81382.1 - 9.4e-08 32.0 0.3 0.0047 16.5 0.0 2.4 1 1 1 2 2 2 2 X-Pro dipeptidyl-peptidase (S15 family) DLH PF01738.18 EXF81382.1 - 1.4e-05 24.8 0.2 7.6e-05 22.4 0.2 2.0 1 1 0 1 1 1 1 Dienelactone hydrolase family LIP PF03583.14 EXF81382.1 - 0.0024 17.3 0.0 0.005 16.2 0.0 1.4 1 0 0 1 1 1 1 Secretory lipase Abhydrolase_1 PF00561.20 EXF81382.1 - 0.0072 16.0 0.2 0.058 13.0 0.2 2.0 1 1 1 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_3 PF07859.13 EXF81382.1 - 0.016 15.1 0.0 0.03 14.2 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold PD40 PF07676.12 EXF81382.1 - 0.055 13.4 0.1 8.8 6.4 0.0 2.9 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat PQQ PF01011.21 EXF81382.1 - 0.064 13.2 0.0 12 6.1 0.0 3.3 3 0 0 3 3 3 0 PQQ enzyme repeat FSH1 PF03959.13 EXF81382.1 - 0.11 12.1 0.0 0.26 10.9 0.0 1.6 1 1 0 1 1 1 0 Serine hydrolase (FSH1) DUF4926 PF16277.5 EXF81384.1 - 0.039 13.3 0.2 0.13 11.6 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4926) Fungal_trans PF04082.18 EXF81385.1 - 1.8e-56 191.1 0.1 2.7e-56 190.5 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 EXF81385.1 - 1e-06 28.9 6.5 0.016 15.7 0.2 3.0 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EXF81385.1 - 0.00044 20.9 5.8 0.5 11.4 0.2 3.2 2 0 0 2 2 2 2 C2H2-type zinc finger FOXP-CC PF16159.5 EXF81385.1 - 0.086 13.5 1.9 2.9 8.6 0.4 2.6 1 1 1 2 2 2 0 FOXP coiled-coil domain zf-H2C2_2 PF13465.6 EXF81385.1 - 3.1 8.4 4.7 2.9 8.5 0.2 2.8 2 0 0 2 2 2 0 Zinc-finger double domain Ribosomal_S8 PF00410.19 EXF81386.1 - 9e-09 35.3 0.0 1.8e-08 34.4 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein S8 Cupin_1 PF00190.22 EXF81387.1 - 2e-20 72.9 0.0 3.4e-20 72.2 0.0 1.3 1 0 0 1 1 1 1 Cupin Cupin_2 PF07883.11 EXF81387.1 - 0.0021 17.7 0.0 0.0079 15.9 0.0 1.9 1 1 0 1 1 1 1 Cupin domain Ank_2 PF12796.7 EXF81388.1 - 7.7e-18 64.9 0.3 1.9e-13 50.8 0.1 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EXF81388.1 - 5.4e-15 55.6 0.0 1.3e-07 32.0 0.0 2.3 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 EXF81388.1 - 1.5e-14 53.9 0.1 4.1e-07 30.1 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EXF81388.1 - 1.4e-11 43.6 0.0 0.00012 22.2 0.0 3.1 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 EXF81388.1 - 1e-10 41.5 0.1 0.00011 22.5 0.1 2.7 3 0 0 3 3 3 2 Ankyrin repeat Phe_tRNA-synt_N PF02912.18 EXF81388.1 - 0.014 15.4 0.0 0.06 13.3 0.0 1.9 2 0 0 2 2 2 0 Aminoacyl tRNA synthetase class II, N-terminal domain TP6A_N PF04406.14 EXF81389.1 - 2e-17 62.9 0.1 3.8e-17 62.0 0.1 1.5 1 0 0 1 1 1 1 Type IIB DNA topoisomerase SQHop_cyclase_C PF13243.6 EXF81390.1 - 2.6e-36 125.3 1.4 9.3e-20 71.0 0.1 3.9 2 2 2 4 4 4 3 Squalene-hopene cyclase C-terminal domain SQHop_cyclase_N PF13249.6 EXF81390.1 - 4.6e-35 121.1 7.3 1.4e-32 113.0 1.4 3.4 4 0 0 4 4 4 2 Squalene-hopene cyclase N-terminal domain Prenyltrans PF00432.21 EXF81390.1 - 3e-20 71.6 6.3 8.2e-10 38.3 0.5 5.6 5 0 0 5 5 5 2 Prenyltransferase and squalene oxidase repeat Phage_F PF02305.17 EXF81390.1 - 0.03 13.1 0.1 0.046 12.5 0.1 1.1 1 0 0 1 1 1 0 Capsid protein (F protein) SGS PF05002.15 EXF81391.1 - 2.6e-29 101.2 1.3 8.6e-29 99.5 1.3 1.9 1 0 0 1 1 1 1 SGS domain CS PF04969.16 EXF81391.1 - 2.4e-11 44.5 0.1 6e-11 43.2 0.0 1.8 2 0 0 2 2 2 1 CS domain TPR_2 PF07719.17 EXF81391.1 - 4.4e-05 23.3 0.1 0.84 9.9 0.1 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 EXF81391.1 - 0.0011 19.6 3.1 1.2 9.9 5.5 3.1 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 EXF81391.1 - 0.02 14.7 0.1 0.55 10.1 0.1 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.6 EXF81391.1 - 0.16 11.7 0.0 7.4 6.4 0.0 2.3 2 0 0 2 2 2 0 TPR repeat TPR_6 PF13174.6 EXF81391.1 - 0.3 11.8 1.8 2.5 8.9 0.1 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TauD PF02668.16 EXF81392.1 - 1.3e-44 153.0 0.0 2.3e-44 152.2 0.0 1.4 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF971 PF06155.12 EXF81392.1 - 4.1e-06 27.3 0.1 1.3e-05 25.7 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF971) CsiD PF08943.10 EXF81392.1 - 0.00054 19.2 0.0 0.0011 18.1 0.0 1.6 1 1 0 1 1 1 1 CsiD Lipase_GDSL_2 PF13472.6 EXF81393.1 - 1.2e-12 48.6 0.6 1.8e-12 48.1 0.6 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EXF81393.1 - 2.3e-07 31.0 0.4 3.5e-07 30.4 0.4 1.3 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase DHquinase_I PF01487.15 EXF81393.1 - 0.11 12.7 0.0 0.17 12.1 0.0 1.2 1 0 0 1 1 1 0 Type I 3-dehydroquinase tRNA_int_endo PF01974.17 EXF81394.1 - 8.1e-17 61.1 0.0 1.6e-16 60.1 0.0 1.5 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain tRNA_int_endo_N PF02778.14 EXF81394.1 - 0.0012 18.5 0.0 0.59 9.8 0.0 2.5 2 0 0 2 2 2 2 tRNA intron endonuclease, N-terminal domain Glyco_transf_21 PF13506.6 EXF81395.1 - 1.4e-11 44.2 0.0 0.00021 20.8 0.0 3.3 3 0 0 3 3 3 3 Glycosyl transferase family 21 Glyco_tranf_2_3 PF13641.6 EXF81395.1 - 1.4e-05 25.1 0.0 0.0002 21.3 0.0 2.5 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 EXF81395.1 - 0.0014 18.5 0.0 0.015 15.1 0.0 2.1 2 0 0 2 2 2 1 Glycosyl transferase family 2 DUF1970 PF09301.10 EXF81395.1 - 0.15 12.3 1.4 1.9 8.8 0.4 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF1970) Tannase PF07519.11 EXF81396.1 - 5.2e-120 401.5 0.1 6.1e-120 401.3 0.1 1.0 1 0 0 1 1 1 1 Tannase and feruloyl esterase Hydrolase_4 PF12146.8 EXF81396.1 - 0.025 13.8 0.0 0.046 13.0 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EXF81396.1 - 0.083 12.5 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Fungal_trans_2 PF11951.8 EXF81397.1 - 9.2e-09 34.6 0.0 1.1e-08 34.4 0.0 1.0 1 0 0 1 1 1 1 Fungal specific transcription factor domain NUDIX PF00293.28 EXF81398.1 - 0.0022 18.0 0.0 0.0044 17.1 0.0 1.6 1 0 0 1 1 1 1 NUDIX domain MFS_1 PF07690.16 EXF81399.1 - 4.8e-06 25.7 20.4 1.2e-05 24.5 10.9 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF202 PF02656.15 EXF81399.1 - 0.49 10.9 12.0 2.8 8.5 0.1 3.2 2 2 1 3 3 3 0 Domain of unknown function (DUF202) DUF2721 PF11026.8 EXF81399.1 - 2 8.3 9.0 1.5 8.7 0.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2721) Acyl-CoA_dh_2 PF08028.11 EXF81400.1 - 2.4e-13 50.5 0.0 2.4e-13 50.5 0.0 1.5 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 EXF81400.1 - 8.7e-05 22.6 0.3 0.00028 21.0 0.0 1.9 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 EXF81400.1 - 0.00075 20.1 0.0 0.0013 19.4 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_1 PF00441.24 EXF81400.1 - 0.0082 16.4 1.5 0.048 13.9 0.1 2.3 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Gpr1_Fun34_YaaH PF01184.19 EXF81401.1 - 1.5e-41 142.3 16.8 1.9e-41 141.9 16.8 1.0 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family DUF3784 PF12650.7 EXF81401.1 - 0.031 14.4 3.4 0.031 14.4 3.4 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF3784) Bac_luciferase PF00296.20 EXF81402.1 - 3.2e-63 214.0 0.0 4.2e-63 213.7 0.0 1.1 1 0 0 1 1 1 1 Luciferase-like monooxygenase p450 PF00067.22 EXF81403.1 - 2e-57 195.0 0.0 3.1e-57 194.4 0.0 1.3 1 1 0 1 1 1 1 Cytochrome P450 Cys_rich_FGFR PF00839.17 EXF81403.1 - 0.18 12.0 0.3 0.43 10.8 0.3 1.5 1 0 0 1 1 1 0 Cysteine rich repeat Mito_carr PF00153.27 EXF81404.1 - 1.4e-19 69.8 6.4 2.3e-08 33.8 0.2 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein Glyco_hydro_61 PF03443.14 EXF81406.1 - 4.6e-46 157.4 0.0 7.4e-46 156.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 zf-C2H2_4 PF13894.6 EXF81407.1 - 0.051 14.4 1.1 0.1 13.5 1.1 1.5 1 0 0 1 1 1 0 C2H2-type zinc finger Oxidored_FMN PF00724.20 EXF81407.1 - 0.097 11.9 0.0 0.16 11.2 0.0 1.3 1 0 0 1 1 1 0 NADH:flavin oxidoreductase / NADH oxidase family zf-C2H2 PF00096.26 EXF81407.1 - 0.14 12.7 1.9 0.3 11.6 1.9 1.5 1 0 0 1 1 1 0 Zinc finger, C2H2 type SasG_E PF17041.5 EXF81408.1 - 0.025 14.6 0.1 0.1 12.6 0.1 2.0 1 0 0 1 1 1 0 E domain Tyrosinase PF00264.20 EXF81410.1 - 1.1e-28 101.0 5.1 1.9e-27 97.0 5.1 2.1 1 1 0 1 1 1 1 Common central domain of tyrosinase MS_channel PF00924.18 EXF81411.1 - 3.2e-21 75.8 0.4 5.2e-21 75.2 0.4 1.3 1 0 0 1 1 1 1 Mechanosensitive ion channel EF-hand_7 PF13499.6 EXF81411.1 - 0.0036 17.7 1.0 0.016 15.7 0.6 2.3 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 EXF81411.1 - 0.021 14.7 0.2 0.37 10.9 0.1 2.6 2 0 0 2 2 2 0 EF-hand domain EF-hand_1 PF00036.32 EXF81411.1 - 0.031 13.8 0.3 0.094 12.3 0.3 1.9 1 0 0 1 1 1 0 EF hand Cecropin PF00272.19 EXF81411.1 - 0.15 11.8 3.7 0.43 10.3 2.6 2.2 2 0 0 2 2 2 0 Cecropin family EF-hand_5 PF13202.6 EXF81411.1 - 0.15 11.6 0.2 0.46 10.1 0.2 1.7 1 0 0 1 1 1 0 EF hand Glyco_hydro_106 PF17132.4 EXF81412.1 - 4.5e-29 101.3 1.1 1.4e-28 99.7 1.1 1.7 1 1 0 1 1 1 1 alpha-L-rhamnosidase Glyco_hydro_2_N PF02837.18 EXF81412.1 - 5.6e-05 23.1 0.0 0.00014 21.8 0.0 1.6 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Malt_amylase_C PF16657.5 EXF81412.1 - 0.057 13.5 0.0 0.19 11.8 0.0 2.0 1 1 0 1 1 1 0 Maltogenic Amylase, C-terminal domain ADH_zinc_N PF00107.26 EXF81413.1 - 1.1e-09 38.4 0.0 1.8e-09 37.6 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EXF81413.1 - 1.4e-05 24.9 0.0 2.6e-05 24.0 0.0 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 EXF81413.1 - 0.00011 23.3 0.0 0.00024 22.1 0.0 1.7 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 EXF81413.1 - 0.036 14.0 0.0 0.07 13.0 0.0 1.4 1 0 0 1 1 1 0 N-terminal domain of oxidoreductase Glyco_hydro_31 PF01055.26 EXF81414.1 - 1.5e-139 466.0 3.4 2.2e-139 465.4 3.4 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 EXF81414.1 - 3.4e-23 81.8 0.4 1e-22 80.2 0.1 2.1 2 0 0 2 2 2 1 Galactose mutarotase-like DUF5110 PF17137.4 EXF81414.1 - 1.3e-07 31.8 0.9 8.4e-07 29.2 0.6 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF5110) COesterase PF00135.28 EXF81415.1 - 1.6e-88 297.8 0.0 1.8e-88 297.6 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EXF81415.1 - 6.5e-06 26.1 0.2 8.2e-05 22.6 0.2 2.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold NDK PF00334.19 EXF81416.1 - 9e-53 177.9 0.0 1.3e-52 177.4 0.0 1.2 1 0 0 1 1 1 1 Nucleoside diphosphate kinase FLILHELTA PF10306.9 EXF81417.1 - 1.3e-29 102.4 0.0 3.1e-29 101.2 0.0 1.6 1 0 0 1 1 1 1 Hypothetical protein FLILHELTA DUF1279 PF06916.13 EXF81417.1 - 0.014 15.9 0.0 0.021 15.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1279) Glyco_hydro_17 PF00332.18 EXF81419.1 - 2.8e-08 33.7 1.2 3.3e-08 33.5 0.3 1.7 2 0 0 2 2 2 1 Glycosyl hydrolases family 17 DUF992 PF06186.11 EXF81419.1 - 0.055 13.3 0.1 0.15 11.9 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF992) Sugar_tr PF00083.24 EXF81420.1 - 1.9e-15 56.7 0.4 3.4e-09 36.1 0.0 2.0 1 1 1 2 2 2 2 Sugar (and other) transporter Goodbye PF17109.5 EXF81421.1 - 4.7e-26 91.6 0.1 5.9e-25 88.1 0.0 3.0 2 0 0 2 2 2 1 fungal STAND N-terminal Goodbye domain TPR_12 PF13424.6 EXF81421.1 - 1.9e-14 53.7 5.5 6.1e-06 26.4 0.0 5.4 6 0 0 6 6 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 EXF81421.1 - 7.9e-08 31.9 3.2 0.19 12.0 0.2 5.0 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 EXF81421.1 - 4.4e-07 29.5 7.4 0.12 12.5 0.0 6.1 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_1 PF00515.28 EXF81421.1 - 8.3e-07 28.6 0.7 0.73 9.8 0.2 4.1 3 0 0 3 3 3 2 Tetratricopeptide repeat AAA_16 PF13191.6 EXF81421.1 - 0.00016 22.1 0.5 0.0018 18.7 0.0 2.9 2 1 1 3 3 3 1 AAA ATPase domain NACHT PF05729.12 EXF81421.1 - 0.00017 21.5 0.0 0.00049 20.1 0.0 1.8 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 EXF81421.1 - 0.00037 20.8 2.2 0.0014 19.0 0.1 3.0 3 1 0 3 3 3 1 AAA domain TPR_14 PF13428.6 EXF81421.1 - 0.0014 19.2 6.4 5.7 8.0 0.0 6.0 5 1 1 6 6 4 1 Tetratricopeptide repeat MMR_HSR1 PF01926.23 EXF81421.1 - 0.016 15.3 0.0 0.081 13.0 0.0 2.3 2 0 0 2 2 1 0 50S ribosome-binding GTPase Dynamin_N PF00350.23 EXF81421.1 - 0.065 13.3 0.0 0.24 11.4 0.0 2.0 1 0 0 1 1 1 0 Dynamin family AAA_29 PF13555.6 EXF81421.1 - 0.082 12.7 0.0 0.27 11.0 0.0 1.9 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_21 PF13304.6 EXF81421.1 - 0.086 12.6 0.2 0.22 11.3 0.2 1.7 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system ACP_PD PF04336.12 EXF81421.1 - 0.14 12.6 2.6 1.4 9.4 0.1 3.7 3 0 0 3 3 2 0 Acyl carrier protein phosphodiesterase AAA PF00004.29 EXF81421.1 - 0.17 12.3 3.0 2.5 8.5 0.1 3.7 4 1 0 4 4 3 0 ATPase family associated with various cellular activities (AAA) ATPase_2 PF01637.18 EXF81421.1 - 0.18 11.7 2.6 0.27 11.1 0.0 2.4 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea IBR PF01485.21 EXF81421.1 - 0.48 10.7 2.9 1.6 9.0 2.9 1.9 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain TPR_7 PF13176.6 EXF81421.1 - 0.59 10.3 5.2 3.3 8.0 0.0 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_10 PF13374.6 EXF81421.1 - 0.72 9.8 4.8 47 4.0 0.3 5.2 5 0 0 5 5 5 0 Tetratricopeptide repeat ZZ PF00569.17 EXF81421.1 - 1.3 8.9 12.7 0.062 13.1 6.8 1.9 2 0 0 2 2 2 0 Zinc finger, ZZ type AAA_14 PF13173.6 EXF81421.1 - 9.8 6.2 7.2 1.7 8.7 0.0 3.4 4 1 0 4 4 4 0 AAA domain Pyrophosphatase PF00719.19 EXF81422.1 - 7.3e-43 146.1 0.0 1.1e-42 145.6 0.0 1.3 1 0 0 1 1 1 1 Inorganic pyrophosphatase RTA1 PF04479.13 EXF81424.1 - 3.1e-56 190.3 8.6 3.1e-56 190.3 8.6 1.3 2 0 0 2 2 2 1 RTA1 like protein Phage_Gp23 PF10669.9 EXF81424.1 - 0.17 12.2 0.1 4.9 7.5 0.0 2.4 2 0 0 2 2 2 0 Protein gp23 (Bacteriophage A118) MFS_1 PF07690.16 EXF81425.1 - 3e-45 154.7 55.4 3.3e-41 141.4 30.2 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF81425.1 - 2.3e-17 63.0 9.8 2.2e-16 59.8 2.1 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_4 PF06779.14 EXF81425.1 - 7e-05 22.3 11.4 0.015 14.6 0.4 2.5 3 0 0 3 3 3 2 Uncharacterised MFS-type transporter YbfB Fungal_trans PF04082.18 EXF81426.1 - 2e-25 89.3 0.0 3.1e-25 88.7 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain FAD_binding_3 PF01494.19 EXF81427.1 - 7.3e-09 35.3 0.0 8.9e-08 31.7 0.0 2.3 2 1 0 2 2 2 1 FAD binding domain Pyr_redox PF00070.27 EXF81427.1 - 0.00054 20.5 0.7 0.0029 18.2 0.0 2.5 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EXF81427.1 - 0.0006 19.1 0.7 0.028 13.7 0.0 2.6 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EXF81427.1 - 0.14 11.7 0.0 0.31 10.6 0.0 1.5 1 1 0 1 1 1 0 FAD dependent oxidoreductase Voldacs PF03517.13 EXF81429.1 - 3.8e-19 69.2 1.2 6.2e-19 68.5 0.1 1.9 2 1 0 2 2 2 1 Regulator of volume decrease after cellular swelling DUF1388 PF07142.12 EXF81430.1 - 0.17 11.9 13.8 0.15 12.1 8.8 3.4 2 1 0 2 2 2 0 Repeat of unknown function (DUF1388) Melibiase_2 PF16499.5 EXF81431.1 - 8.2e-51 172.8 6.6 5.3e-38 130.8 1.5 2.3 2 0 0 2 2 2 2 Alpha galactosidase A Melibiase_C PF17801.1 EXF81431.1 - 2.3e-14 53.2 0.8 2.2e-12 46.9 0.1 2.5 2 0 0 2 2 2 2 Alpha galactosidase C-terminal beta sandwich domain Melibiase PF02065.18 EXF81431.1 - 7.7e-07 28.4 0.4 1.2e-06 27.7 0.0 1.4 2 0 0 2 2 2 1 Melibiase FAD_binding_4 PF01565.23 EXF81432.1 - 8.8e-22 77.3 2.8 1.5e-21 76.6 2.8 1.4 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EXF81432.1 - 0.02 15.0 0.0 0.037 14.1 0.0 1.4 1 0 0 1 1 1 0 Berberine and berberine like DUF1996 PF09362.10 EXF81433.1 - 3.9e-81 272.5 0.1 5.3e-81 272.0 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1996) TPR_2 PF07719.17 EXF81434.1 - 0.00014 21.7 0.0 3.6 7.9 0.0 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 EXF81434.1 - 0.003 17.3 0.0 0.82 9.6 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat UBA PF00627.31 EXF81434.1 - 0.0083 16.0 0.1 0.018 14.9 0.1 1.6 1 0 0 1 1 1 1 UBA/TS-N domain TPR_12 PF13424.6 EXF81434.1 - 0.028 14.7 0.0 0.76 10.1 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat DnaJ PF00226.31 EXF81434.1 - 0.031 14.4 0.0 0.082 13.0 0.0 1.7 1 0 0 1 1 1 0 DnaJ domain KAsynt_C_assoc PF16197.5 EXF81434.1 - 0.12 12.8 0.2 0.33 11.4 0.2 1.7 1 0 0 1 1 1 0 Ketoacyl-synthetase C-terminal extension UQ_con PF00179.26 EXF81435.1 - 4.1e-51 172.3 0.0 4.6e-51 172.2 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EXF81435.1 - 0.079 12.7 0.0 0.15 11.7 0.0 1.7 1 1 0 1 1 1 0 Prokaryotic E2 family B LSM PF01423.22 EXF81437.1 - 1.8e-16 59.5 0.2 2.7e-16 59.0 0.2 1.3 1 0 0 1 1 1 1 LSM domain DPPIV_N PF00930.21 EXF81438.1 - 2.8e-108 361.8 0.6 4e-108 361.4 0.6 1.2 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.21 EXF81438.1 - 3.4e-38 131.3 0.1 5.9e-38 130.5 0.1 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 EXF81438.1 - 0.00086 20.0 0.0 0.0027 18.3 0.0 1.9 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EXF81438.1 - 0.021 14.1 0.0 0.059 12.6 0.0 1.7 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Pkinase PF00069.25 EXF81439.1 - 9.3e-15 54.7 0.0 1.1e-11 44.6 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EXF81439.1 - 5e-08 32.5 0.1 0.0014 18.0 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Choline_kinase PF01633.20 EXF81439.1 - 5.9e-05 22.8 0.0 0.00011 21.9 0.0 1.4 1 0 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.23 EXF81439.1 - 0.0014 18.6 0.3 0.0049 16.8 0.3 1.8 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 EXF81439.1 - 0.02 14.3 0.0 0.03 13.7 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Methyltransf_33 PF10017.9 EXF81440.1 - 9e-83 278.0 0.0 1.5e-82 277.2 0.0 1.3 1 0 0 1 1 1 1 Histidine-specific methyltransferase, SAM-dependent FGE-sulfatase PF03781.16 EXF81440.1 - 1.4e-15 57.6 2.0 1.3e-09 38.0 0.1 2.8 2 1 0 2 2 2 2 Sulfatase-modifying factor enzyme 1 DinB_2 PF12867.7 EXF81440.1 - 9.2e-05 23.0 1.5 0.00039 20.9 1.4 2.2 1 1 0 1 1 1 1 DinB superfamily Peptidase_S28 PF05577.12 EXF81441.1 - 2.1e-50 171.8 1.3 1.5e-49 169.0 1.3 1.9 1 1 0 1 1 1 1 Serine carboxypeptidase S28 DUF2920 PF11144.8 EXF81441.1 - 0.17 11.0 0.0 0.26 10.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2920) Fungal_trans PF04082.18 EXF81442.1 - 2.7e-15 56.1 0.0 4.4e-15 55.4 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF81442.1 - 7.8e-08 32.3 7.7 1.4e-07 31.5 7.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MGTL PF17059.5 EXF81442.1 - 0.18 11.6 0.8 0.6 10.0 0.8 1.9 1 0 0 1 1 1 0 MgtA leader peptide SSP160 PF06933.11 EXF81444.1 - 3.4 5.7 10.2 4.3 5.4 10.2 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 DUF3482 PF11981.8 EXF81447.1 - 2 7.8 9.2 0.97 8.8 5.8 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3482) Ank_4 PF13637.6 EXF81448.1 - 2.4e-34 117.3 5.8 5.9e-06 26.7 0.0 9.4 6 1 2 8 8 8 6 Ankyrin repeats (many copies) Ank_2 PF12796.7 EXF81448.1 - 8.6e-34 116.0 6.3 1.3e-09 38.5 0.0 7.2 4 2 2 6 6 6 6 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EXF81448.1 - 4.5e-28 94.2 12.4 0.12 13.0 0.0 11.3 12 0 0 12 12 12 7 Ankyrin repeat Ank_5 PF13857.6 EXF81448.1 - 7.3e-16 58.0 8.3 0.0023 18.2 0.1 7.6 7 2 2 9 9 9 6 Ankyrin repeats (many copies) Ank PF00023.30 EXF81448.1 - 7.5e-13 48.3 18.5 0.35 11.4 0.1 9.8 11 0 0 11 11 11 4 Ankyrin repeat Clr5 PF14420.6 EXF81448.1 - 7.5e-07 29.3 0.4 1.7e-06 28.1 0.4 1.6 1 0 0 1 1 1 1 Clr5 domain AP_endonuc_2 PF01261.24 EXF81448.1 - 0.012 15.1 0.2 0.39 10.1 0.0 2.3 2 0 0 2 2 2 0 Xylose isomerase-like TIM barrel EccE PF11203.8 EXF81448.1 - 6.7 7.1 6.7 12 6.3 0.2 3.5 3 0 0 3 3 3 0 Putative type VII ESX secretion system translocon, EccE SDA1 PF05285.12 EXF81449.1 - 6.6e-90 302.0 60.3 5.5e-89 299.0 52.2 3.0 2 1 0 2 2 2 1 SDA1 NUC130_3NT PF08158.12 EXF81449.1 - 2.6e-19 69.3 0.2 7.4e-19 67.8 0.2 1.8 1 0 0 1 1 1 1 NUC130/3NT domain YL1 PF05764.13 EXF81449.1 - 0.047 13.8 38.7 0.99 9.5 1.0 2.4 2 0 0 2 2 2 0 YL1 nuclear protein CSD2 PF17876.1 EXF81449.1 - 0.14 12.4 0.6 0.69 10.1 0.8 2.1 2 0 0 2 2 2 0 Cold shock domain MFS_1 PF07690.16 EXF81451.1 - 1.2e-20 73.7 67.3 1.1e-17 64.0 62.2 4.0 1 1 1 2 2 2 2 Major Facilitator Superfamily PAM2 PF07145.15 EXF81452.1 - 0.081 12.6 0.3 0.081 12.6 0.3 2.7 3 0 0 3 3 3 0 Ataxin-2 C-terminal region AMP-binding PF00501.28 EXF81453.1 - 5.1e-77 259.3 0.0 6.8e-77 258.8 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EXF81453.1 - 2e-06 28.7 0.0 5e-06 27.4 0.0 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain DUF5386 PF17360.2 EXF81453.1 - 0.11 12.4 0.0 0.2 11.6 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5386) DUF3483 PF11982.8 EXF81454.1 - 0.028 14.1 0.1 0.028 14.1 0.1 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3483) MFS_1 PF07690.16 EXF81455.1 - 8.7e-30 103.8 55.9 1.9e-24 86.2 29.7 1.7 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EXF81455.1 - 4.4e-05 22.1 2.2 4.4e-05 22.1 2.2 2.0 1 1 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) p450 PF00067.22 EXF81456.1 - 9.8e-68 229.0 0.0 1.6e-67 228.2 0.0 1.3 1 1 0 1 1 1 1 Cytochrome P450 Amidase PF01425.21 EXF81457.1 - 6.8e-98 328.6 0.0 1.7e-97 327.3 0.0 1.6 1 1 0 1 1 1 1 Amidase Fungal_trans_2 PF11951.8 EXF81458.1 - 1.3e-13 50.6 1.0 6.3e-13 48.3 1.0 2.0 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF81458.1 - 2.9e-07 30.5 8.7 5.9e-07 29.5 8.7 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PSI_integrin PF17205.3 EXF81458.1 - 0.65 9.8 5.7 0.85 9.4 4.5 1.9 1 1 0 1 1 1 0 Integrin plexin domain MFS_1 PF07690.16 EXF81459.1 - 5.1e-18 65.1 19.0 2.5e-14 53.0 6.3 3.2 1 1 2 3 3 3 3 Major Facilitator Superfamily Bacteriocin_IIc PF10439.9 EXF81459.1 - 4.6 7.4 9.2 14 5.9 9.2 1.9 1 0 0 1 1 1 0 Bacteriocin class II with double-glycine leader peptide Amidase PF01425.21 EXF81460.1 - 2.3e-95 320.2 0.0 3.6e-95 319.6 0.0 1.3 1 1 0 1 1 1 1 Amidase Amino_oxidase PF01593.24 EXF81461.1 - 2e-55 188.9 0.1 2.5e-55 188.6 0.1 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase Ribonuc_L-PSP PF01042.21 EXF81461.1 - 1.1e-15 57.7 0.0 2e-15 56.9 0.0 1.4 1 0 0 1 1 1 1 Endoribonuclease L-PSP NAD_binding_8 PF13450.6 EXF81461.1 - 2.5e-14 53.2 0.1 7.1e-14 51.8 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EXF81461.1 - 7.4e-10 38.5 0.2 1.4e-09 37.6 0.2 1.4 1 0 0 1 1 1 1 FAD binding domain Lycopene_cycl PF05834.12 EXF81461.1 - 5.1e-09 35.7 0.4 6.6e-06 25.4 0.4 2.2 2 0 0 2 2 2 2 Lycopene cyclase protein DAO PF01266.24 EXF81461.1 - 6.3e-07 29.3 0.0 1.3e-06 28.3 0.0 1.7 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_oxidored PF12831.7 EXF81461.1 - 7.6e-07 28.8 0.1 1.3e-06 28.0 0.1 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 EXF81461.1 - 2.1e-06 27.1 0.2 3.7e-06 26.4 0.2 1.3 1 0 0 1 1 1 1 Thi4 family FAD_binding_3 PF01494.19 EXF81461.1 - 6.9e-06 25.5 1.1 1.1e-05 24.9 1.1 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.6 EXF81461.1 - 8.1e-06 25.3 1.3 0.0012 18.2 0.1 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EXF81461.1 - 1.9e-05 24.1 0.1 5.7e-05 22.5 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EXF81461.1 - 3.8e-05 22.6 0.5 0.00021 20.1 0.2 2.0 2 0 0 2 2 2 1 HI0933-like protein GIDA PF01134.22 EXF81461.1 - 0.0014 17.8 1.4 0.0019 17.3 0.5 1.7 2 0 0 2 2 2 1 Glucose inhibited division protein A AlaDh_PNT_C PF01262.21 EXF81461.1 - 0.0064 15.8 0.1 0.015 14.6 0.1 1.6 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox PF00070.27 EXF81461.1 - 0.011 16.3 1.5 0.014 16.0 0.1 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase RE_SinI PF09570.10 EXF81462.1 - 0.09 12.0 0.0 0.14 11.3 0.0 1.4 1 0 0 1 1 1 0 SinI restriction endonuclease Aldolase_II PF00596.21 EXF81463.1 - 1.7e-48 165.1 0.0 2.1e-48 164.7 0.0 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain DUF3148 PF11347.8 EXF81463.1 - 0.079 12.7 0.0 0.5 10.2 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3148) Fungal_trans_2 PF11951.8 EXF81464.1 - 7.6e-65 219.2 0.3 1.3e-64 218.4 0.3 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain MFS_1 PF07690.16 EXF81465.1 - 1e-19 70.7 13.4 1.7e-19 70.0 13.4 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily TMEM132D_C PF15706.5 EXF81465.1 - 0.0054 16.5 0.0 0.012 15.4 0.0 1.5 1 0 0 1 1 1 1 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term CD34_antigen PF06365.12 EXF81465.1 - 0.11 12.1 0.0 0.18 11.4 0.0 1.3 1 0 0 1 1 1 0 CD34/Podocalyxin family NAD_binding_2 PF03446.15 EXF81466.1 - 1.5e-30 106.5 0.7 2.3e-30 105.8 0.7 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 EXF81466.1 - 2.8e-08 34.0 0.4 6.4e-08 32.9 0.0 1.7 2 0 0 2 2 2 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase Peptidase_S8 PF00082.22 EXF81467.1 - 1.9e-28 99.6 6.3 3.7e-28 98.7 6.3 1.5 1 1 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 EXF81467.1 - 2.2e-12 47.5 0.0 3.7e-12 46.7 0.0 1.4 1 0 0 1 1 1 1 Peptidase inhibitor I9 FMN_bind PF04205.14 EXF81467.1 - 0.01 16.4 3.1 0.029 15.0 3.1 1.8 1 0 0 1 1 1 0 FMN-binding domain Alpha-amylase PF00128.24 EXF81468.1 - 2.8e-24 86.3 6.2 6.4e-24 85.1 6.2 1.4 1 1 0 1 1 1 1 Alpha amylase, catalytic domain Glyco_hydro_70 PF02324.16 EXF81468.1 - 3.1e-07 29.0 2.4 0.097 10.8 0.1 3.1 3 0 0 3 3 3 3 Glycosyl hydrolase family 70 DUF1939 PF09154.10 EXF81468.1 - 0.023 14.9 0.3 0.1 12.7 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1939) Aldedh PF00171.22 EXF81469.1 - 4.4e-180 599.1 1.2 5e-180 598.9 1.2 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 EXF81469.1 - 0.066 12.7 0.0 1.6 8.1 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1487) Bac_rhamnosid6H PF17389.2 EXF81470.1 - 6.7e-91 305.1 0.7 8.7e-91 304.7 0.7 1.1 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain Bac_rhamnosid_N PF08531.10 EXF81470.1 - 5.9e-52 176.0 0.0 9.1e-52 175.4 0.0 1.3 1 0 0 1 1 1 1 Alpha-L-rhamnosidase N-terminal domain Bac_rhamnosid PF05592.11 EXF81470.1 - 1.7e-18 66.5 0.0 4.5e-18 65.1 0.0 1.8 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase concanavalin-like domain Bac_rhamnosid_C PF17390.2 EXF81470.1 - 5.8e-17 61.2 0.3 1.4e-16 60.0 0.1 1.7 2 0 0 2 2 2 1 Bacterial alpha-L-rhamnosidase C-terminal domain Pab87_oct PF13969.6 EXF81470.1 - 0.074 13.1 0.1 0.31 11.1 0.0 2.0 2 0 0 2 2 2 0 Pab87 octamerisation domain DUF2914 PF11141.8 EXF81470.1 - 0.31 10.8 1.7 7.4 6.4 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2914) Sugar_tr PF00083.24 EXF81471.1 - 6.5e-104 348.3 20.2 7.4e-104 348.1 20.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF81471.1 - 4.8e-31 108.0 38.6 4.6e-28 98.2 23.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_5 PF05631.14 EXF81471.1 - 1.4e-06 27.5 1.7 1.4e-06 27.5 1.7 1.8 2 0 0 2 2 2 1 Sugar-tranasporters, 12 TM CoA_binding_3 PF13727.6 EXF81471.1 - 0.3 11.1 2.1 0.33 10.9 0.1 2.0 2 0 0 2 2 2 0 CoA-binding domain adh_short PF00106.25 EXF81472.1 - 1e-21 77.3 0.0 2.3e-18 66.4 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EXF81472.1 - 1.2e-09 38.0 0.0 2.2e-09 37.2 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF81472.1 - 6.5e-07 29.4 0.0 1.1e-06 28.7 0.0 1.3 1 0 0 1 1 1 1 KR domain Amidase PF01425.21 EXF81473.1 - 4.6e-31 108.3 0.1 7.4e-31 107.6 0.1 1.2 1 0 0 1 1 1 1 Amidase Ribonucleas_3_3 PF14622.6 EXF81476.1 - 3e-09 37.1 0.0 4.1e-09 36.7 0.0 1.1 1 0 0 1 1 1 1 Ribonuclease-III-like Ribonuclease_3 PF00636.26 EXF81476.1 - 5e-06 27.1 0.0 8.4e-05 23.1 0.0 2.1 1 1 0 1 1 1 1 Ribonuclease III domain GMC_oxred_N PF00732.19 EXF81477.1 - 1.1e-58 198.9 0.0 1.8e-58 198.3 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EXF81477.1 - 9.9e-28 97.5 0.0 2.7e-27 96.1 0.0 1.7 2 0 0 2 2 2 1 GMC oxidoreductase FAD_binding_2 PF00890.24 EXF81477.1 - 7.2e-06 25.3 0.0 0.00051 19.2 0.0 2.2 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_3 PF13738.6 EXF81477.1 - 7.1e-05 22.2 0.2 0.039 13.2 0.1 3.0 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EXF81477.1 - 0.00031 20.9 0.0 0.00079 19.6 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EXF81477.1 - 0.0025 17.5 0.0 0.1 12.2 0.0 2.5 2 0 0 2 2 2 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 EXF81477.1 - 0.0026 16.9 0.1 0.0041 16.2 0.1 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein FAD_binding_3 PF01494.19 EXF81477.1 - 0.017 14.4 0.0 0.025 13.8 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain HI0933_like PF03486.14 EXF81477.1 - 0.062 12.0 0.0 0.091 11.4 0.0 1.2 1 0 0 1 1 1 0 HI0933-like protein Mersacidin PF16934.5 EXF81477.1 - 0.085 12.6 0.0 0.26 11.1 0.0 1.8 1 0 0 1 1 1 0 Two-component Enterococcus faecalis cytolysin (EFC) Thi4 PF01946.17 EXF81477.1 - 0.12 11.6 0.0 0.2 10.8 0.0 1.3 1 0 0 1 1 1 0 Thi4 family TrkA_N PF02254.18 EXF81477.1 - 0.13 12.5 0.0 0.27 11.5 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain bZIP_1 PF00170.21 EXF81478.1 - 1.8e-08 34.3 12.6 3.7e-08 33.3 12.6 1.5 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EXF81478.1 - 0.00033 20.7 11.1 0.00033 20.7 11.1 2.3 2 0 0 2 2 2 1 Basic region leucine zipper DivIC PF04977.15 EXF81478.1 - 0.043 13.6 15.1 0.079 12.7 2.5 2.7 2 0 0 2 2 2 0 Septum formation initiator Pyr_redox_2 PF07992.14 EXF81480.1 - 7.9e-19 68.0 0.0 9.3e-15 54.6 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EXF81480.1 - 1.5e-12 47.5 0.3 1.1e-08 35.2 0.2 2.7 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 EXF81480.1 - 6.5e-12 45.3 0.0 7.5e-09 35.3 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 EXF81480.1 - 3.1e-07 29.2 0.1 0.00019 20.0 0.0 2.2 2 0 0 2 2 2 2 Flavin-binding monooxygenase-like K_oxygenase PF13434.6 EXF81480.1 - 4e-07 29.5 0.4 0.00063 19.0 0.0 2.6 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.24 EXF81480.1 - 1e-06 28.6 6.6 0.0018 17.9 0.0 3.6 3 1 0 3 3 3 2 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EXF81480.1 - 2e-06 27.9 2.5 0.22 11.5 0.1 3.6 3 1 0 3 3 3 2 FAD-NAD(P)-binding Thi4 PF01946.17 EXF81480.1 - 2.1e-05 23.9 1.8 0.02 14.1 0.1 2.8 3 0 0 3 3 3 2 Thi4 family Pyr_redox PF00070.27 EXF81480.1 - 9e-05 23.0 1.0 0.29 11.7 0.0 2.6 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EXF81480.1 - 0.00034 19.8 1.6 0.0017 17.5 0.1 2.3 2 0 0 2 2 2 1 FAD binding domain Lycopene_cycl PF05834.12 EXF81480.1 - 0.0015 17.6 1.5 0.15 11.1 0.1 3.4 3 1 0 3 3 3 1 Lycopene cyclase protein FAD_oxidored PF12831.7 EXF81480.1 - 0.0021 17.5 0.0 0.0044 16.4 0.0 1.6 1 0 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.22 EXF81480.1 - 0.0048 16.0 7.6 0.19 10.8 0.0 3.3 4 0 0 4 4 4 2 Glucose inhibited division protein A HI0933_like PF03486.14 EXF81480.1 - 0.0088 14.8 2.6 1.5 7.4 0.2 3.2 3 0 0 3 3 3 1 HI0933-like protein ThiF PF00899.21 EXF81480.1 - 0.012 15.0 0.2 4.6 6.5 0.0 2.4 2 0 0 2 2 2 0 ThiF family 2-Hacid_dh_C PF02826.19 EXF81480.1 - 0.013 14.9 0.0 0.023 14.1 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain FAD_binding_3 PF01494.19 EXF81480.1 - 0.019 14.2 0.9 0.25 10.6 0.1 2.6 3 0 0 3 3 3 0 FAD binding domain Shikimate_DH PF01488.20 EXF81480.1 - 0.02 15.0 0.0 0.15 12.1 0.0 2.2 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase NAD_binding_7 PF13241.6 EXF81480.1 - 0.02 15.3 0.4 0.45 11.0 0.5 2.7 2 1 0 2 2 2 0 Putative NAD(P)-binding Semialdhyde_dh PF01118.24 EXF81480.1 - 0.054 13.9 0.0 0.45 11.0 0.0 2.3 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain Flavodoxin_3 PF12641.7 EXF81480.1 - 0.12 12.0 0.0 0.46 10.2 0.0 1.9 2 0 0 2 2 2 0 Flavodoxin domain DEAD PF00270.29 EXF81481.1 - 4.1e-16 59.2 0.0 8.6e-16 58.2 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 EXF81481.1 - 2.2e-12 47.3 0.0 5.3e-12 46.1 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EXF81481.1 - 1.6e-07 31.7 0.0 4e-07 30.4 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain PhoH PF02562.16 EXF81481.1 - 0.049 13.1 0.0 0.098 12.1 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein UPF0489 PF12640.7 EXF81481.1 - 0.1 12.8 0.1 0.22 11.7 0.1 1.5 1 0 0 1 1 1 0 UPF0489 domain SPAM PF02090.15 EXF81481.1 - 7.1 6.4 7.9 2 8.2 2.2 2.3 2 0 0 2 2 2 0 Salmonella surface presentation of antigen gene type M protein MFS_1 PF07690.16 EXF81482.1 - 1.9e-28 99.4 32.0 1.9e-28 99.4 32.0 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily NmrA PF05368.13 EXF81483.1 - 1.6e-21 76.9 0.0 3.5e-11 43.1 0.2 2.1 1 1 1 2 2 2 2 NmrA-like family NAD_binding_10 PF13460.6 EXF81483.1 - 4.1e-09 36.6 0.3 4.1e-08 33.3 0.1 2.2 1 1 2 3 3 3 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 EXF81483.1 - 0.00089 19.5 0.7 0.0031 17.8 0.1 1.9 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain Semialdhyde_dh PF01118.24 EXF81483.1 - 0.029 14.8 0.5 0.05 14.0 0.1 1.7 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain NAD_binding_4 PF07993.12 EXF81483.1 - 0.046 12.9 0.1 0.11 11.7 0.0 1.7 2 0 0 2 2 2 0 Male sterility protein DXP_reductoisom PF02670.16 EXF81483.1 - 0.1 13.3 0.7 0.32 11.7 0.2 2.0 2 0 0 2 2 2 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase DapB_N PF01113.20 EXF81483.1 - 0.15 12.2 0.1 0.26 11.4 0.1 1.4 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus DLH PF01738.18 EXF81484.1 - 4.9e-18 65.5 0.0 6.2e-18 65.1 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Peptidase_S9 PF00326.21 EXF81484.1 - 0.1 12.1 0.3 0.65 9.4 0.0 2.0 1 1 1 2 2 2 0 Prolyl oligopeptidase family adh_short PF00106.25 EXF81485.1 - 2.3e-45 154.4 1.1 3.1e-45 154.0 1.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF81485.1 - 1.5e-34 119.5 0.3 1.9e-34 119.2 0.3 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF81485.1 - 1.1e-07 31.9 0.1 2e-07 31.1 0.1 1.4 1 1 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EXF81485.1 - 0.0029 16.8 0.9 0.0089 15.2 0.9 1.8 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein Shikimate_DH PF01488.20 EXF81485.1 - 0.0033 17.5 0.2 0.008 16.2 0.2 1.7 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_10 PF13460.6 EXF81485.1 - 0.006 16.5 0.7 0.068 13.1 0.7 2.1 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EXF81485.1 - 0.0089 15.5 1.0 0.8 9.1 0.2 2.5 2 1 0 2 2 2 2 NAD dependent epimerase/dehydratase family ADH_zinc_N PF00107.26 EXF81485.1 - 0.022 14.8 0.5 0.078 13.0 0.2 2.1 1 1 1 2 2 2 0 Zinc-binding dehydrogenase AdHead_fibreRBD PF16812.5 EXF81485.1 - 0.055 13.3 0.0 0.11 12.3 0.0 1.7 1 1 0 1 1 1 0 C-terminal head domain of the fowl adenovirus type 1 long fibre HDC PF02329.16 EXF81485.1 - 0.063 12.3 0.0 0.67 8.9 0.0 2.1 2 0 0 2 2 2 0 Histidine carboxylase PI chain Dioxygenase_C PF00775.21 EXF81486.1 - 5.3e-40 136.8 0.0 6.3e-40 136.6 0.0 1.0 1 0 0 1 1 1 1 Dioxygenase SpaA PF17802.1 EXF81486.1 - 0.00052 20.3 0.1 0.0012 19.2 0.1 1.5 1 0 0 1 1 1 1 Prealbumin-like fold domain CarboxypepD_reg PF13620.6 EXF81486.1 - 0.03 14.6 0.1 0.14 12.4 0.1 2.1 1 1 0 1 1 1 0 Carboxypeptidase regulatory-like domain adh_short_C2 PF13561.6 EXF81487.1 - 2.7e-51 174.4 0.0 3.9e-51 173.9 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF81487.1 - 1.4e-35 122.5 0.0 2.2e-35 121.9 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EXF81487.1 - 1.8e-10 41.0 0.1 1.8e-10 41.0 0.1 1.6 2 0 0 2 2 2 1 KR domain GDP_Man_Dehyd PF16363.5 EXF81487.1 - 0.13 11.7 0.0 8 5.7 0.0 2.1 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase NACHT PF05729.12 EXF81488.1 - 3.9e-10 39.9 0.1 6e-09 36.0 0.0 2.3 2 0 0 2 2 2 1 NACHT domain Ank_2 PF12796.7 EXF81488.1 - 6.3e-10 39.5 2.0 7e-05 23.3 0.1 4.0 3 1 0 4 4 4 2 Ankyrin repeats (3 copies) Ank PF00023.30 EXF81488.1 - 2.3e-06 27.8 0.3 0.032 14.7 0.1 4.7 4 0 0 4 4 4 1 Ankyrin repeat Ank_4 PF13637.6 EXF81488.1 - 3.6e-06 27.4 1.8 0.0084 16.7 0.0 4.3 4 1 1 5 5 5 1 Ankyrin repeats (many copies) AAA_22 PF13401.6 EXF81488.1 - 0.0015 18.8 0.1 0.14 12.5 0.0 2.9 3 0 0 3 3 3 1 AAA domain AAA_16 PF13191.6 EXF81488.1 - 0.0021 18.4 0.0 0.011 16.2 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain Ank_3 PF13606.6 EXF81488.1 - 0.0037 17.6 4.0 2.8 8.8 0.0 5.5 6 0 0 6 6 5 1 Ankyrin repeat AAA_33 PF13671.6 EXF81488.1 - 0.027 14.7 0.0 0.07 13.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.9 EXF81488.1 - 0.054 12.7 0.0 0.1 11.8 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA PF00004.29 EXF81488.1 - 0.066 13.6 0.0 0.17 12.3 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ResIII PF04851.15 EXF81488.1 - 0.071 13.1 0.0 0.19 11.7 0.0 1.7 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit RuvB_N PF05496.12 EXF81488.1 - 0.084 12.6 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain Fic PF02661.18 EXF81488.1 - 0.12 13.3 0.0 1.3 10.0 0.0 2.4 2 0 0 2 2 2 0 Fic/DOC family AAA_19 PF13245.6 EXF81488.1 - 0.22 11.9 0.0 0.5 10.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain GvpD PF07088.11 EXF81488.1 - 0.24 10.0 0.0 0.37 9.4 0.0 1.2 1 0 0 1 1 1 0 GvpD gas vesicle protein Helo_like_N PF17111.5 EXF81489.1 - 3.8e-12 46.0 2.0 5.1e-12 45.6 2.0 1.2 1 0 0 1 1 1 1 Fungal N-terminal domain of STAND proteins SesA PF17107.5 EXF81489.1 - 0.00067 19.8 4.6 0.0016 18.6 1.3 2.1 1 1 1 2 2 2 1 N-terminal domain on NACHT_NTPase and P-loop NTPases VWA_2 PF13519.6 EXF81489.1 - 0.023 15.3 2.3 1.8 9.2 0.2 2.4 2 1 0 2 2 2 0 von Willebrand factor type A domain HeLo PF14479.6 EXF81489.1 - 0.045 13.6 1.3 0.063 13.1 0.4 1.5 1 1 0 1 1 1 0 Prion-inhibition and propagation YihI PF04220.12 EXF81489.1 - 0.13 12.0 2.0 2.6 7.7 0.1 2.2 1 1 1 2 2 2 0 Der GTPase activator (YihI) Effector_1 PF04518.12 EXF81489.1 - 1 8.4 6.6 0.91 8.6 0.6 2.4 2 1 0 2 2 2 0 Effector from type III secretion system Acyl-CoA_dh_1 PF00441.24 EXF81490.1 - 2.2e-40 138.3 0.8 3.9e-40 137.5 0.8 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 EXF81490.1 - 6.5e-31 107.3 0.1 1.4e-30 106.3 0.1 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 EXF81490.1 - 1.6e-27 95.5 0.4 3.1e-27 94.6 0.4 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 EXF81490.1 - 1.1e-13 51.6 0.3 2e-13 50.8 0.1 1.6 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain HpaB_N PF11794.8 EXF81490.1 - 5.4e-05 23.0 0.1 0.00014 21.6 0.1 1.6 1 1 0 1 1 1 1 4-hydroxyphenylacetate 3-hydroxylase N terminal Carboxyl_trans PF01039.22 EXF81491.1 - 2.6e-138 461.7 0.1 3.5e-138 461.3 0.1 1.1 1 0 0 1 1 1 1 Carboxyl transferase domain NUDIX PF00293.28 EXF81492.1 - 3.7e-11 43.2 0.1 2.1e-10 40.7 0.1 1.9 1 1 0 1 1 1 1 NUDIX domain DLH PF01738.18 EXF81493.1 - 1.6e-18 67.1 0.0 1.9e-18 66.8 0.0 1.0 1 0 0 1 1 1 1 Dienelactone hydrolase family Ank_2 PF12796.7 EXF81494.1 - 5.8e-43 145.4 0.0 1.7e-07 31.7 0.0 7.6 6 3 2 9 9 8 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EXF81494.1 - 1.2e-33 115.0 2.5 3.6e-08 33.8 0.0 10.1 6 5 5 11 11 11 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EXF81494.1 - 1.2e-26 89.8 0.6 0.067 13.8 0.0 11.9 13 0 0 13 13 12 6 Ankyrin repeat Ank_5 PF13857.6 EXF81494.1 - 2.3e-24 85.1 5.6 1.1e-05 25.6 0.0 8.2 4 3 5 10 10 10 6 Ankyrin repeats (many copies) Ank PF00023.30 EXF81494.1 - 2.2e-23 81.6 0.1 0.14 12.6 0.1 11.5 11 0 0 11 11 11 4 Ankyrin repeat AAA_16 PF13191.6 EXF81494.1 - 2.3e-07 31.4 0.0 8.2e-07 29.6 0.0 1.9 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EXF81494.1 - 3.7e-07 30.5 3.9 4.4e-07 30.2 0.1 2.9 3 0 0 3 3 3 1 AAA domain NACHT PF05729.12 EXF81494.1 - 8.1e-06 25.9 1.2 2.2e-05 24.4 0.0 2.2 2 0 0 2 2 2 1 NACHT domain IstB_IS21 PF01695.17 EXF81494.1 - 0.037 13.8 0.1 0.44 10.2 0.1 2.5 1 1 0 1 1 1 0 IstB-like ATP binding protein dCache_2 PF08269.11 EXF81494.1 - 0.45 9.6 2.8 0.38 9.9 0.1 2.2 3 0 0 3 3 3 0 Cache domain PLC-beta_C PF08703.10 EXF81494.1 - 1.9 8.4 7.8 0.84 9.6 3.5 2.7 2 1 0 2 2 2 0 PLC-beta C terminal Ank_4 PF13637.6 EXF81495.1 - 2.7e-18 66.1 0.1 3.1e-08 34.0 0.0 3.4 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 EXF81495.1 - 7.9e-18 64.3 2.0 1.2e-07 31.9 0.2 3.3 2 2 2 4 4 4 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 EXF81495.1 - 6.4e-17 61.9 0.0 2.2e-10 41.0 0.1 2.3 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EXF81495.1 - 5.7e-13 47.8 0.2 0.008 16.6 0.0 5.1 5 0 0 5 5 5 3 Ankyrin repeat Ank PF00023.30 EXF81495.1 - 5.8e-08 32.8 3.4 0.61 10.6 0.2 4.8 5 0 0 5 5 5 3 Ankyrin repeat DGF-1_C PF11040.8 EXF81495.1 - 0.21 11.6 0.6 0.55 10.3 0.1 2.0 2 0 0 2 2 2 0 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus Raptor_N PF14538.6 EXF81496.1 - 3.3e-65 218.5 0.0 6.9e-65 217.5 0.0 1.6 1 0 0 1 1 1 1 Raptor N-terminal CASPase like domain WD40 PF00400.32 EXF81496.1 - 2.4e-07 31.3 0.7 4.5 8.3 0.0 6.1 5 0 0 5 5 5 2 WD domain, G-beta repeat HEAT PF02985.22 EXF81496.1 - 0.0013 18.8 0.9 29 5.3 0.0 5.1 6 0 0 6 6 6 1 HEAT repeat Atx10homo_assoc PF09759.9 EXF81496.1 - 0.015 15.3 0.4 0.028 14.4 0.4 1.4 1 0 0 1 1 1 0 Spinocerebellar ataxia type 10 protein domain BBS2_Mid PF14783.6 EXF81496.1 - 0.018 15.0 0.0 6.9 6.8 0.0 2.6 1 1 1 2 2 2 0 Ciliary BBSome complex subunit 2, middle region HEAT_2 PF13646.6 EXF81496.1 - 0.025 15.0 0.0 1.7 9.1 0.0 3.2 2 1 1 3 3 3 0 HEAT repeats Kelch_4 PF13418.6 EXF81497.1 - 2.2e-34 117.2 7.2 6.6e-07 29.2 0.9 6.5 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_1 PF01344.25 EXF81497.1 - 4e-29 100.0 7.3 3.7e-13 48.8 0.7 6.7 6 0 0 6 6 6 5 Kelch motif Kelch_5 PF13854.6 EXF81497.1 - 1.7e-27 94.9 12.4 2.3e-08 33.8 0.3 6.8 7 0 0 7 7 7 5 Kelch motif Kelch_3 PF13415.6 EXF81497.1 - 1.5e-26 92.1 7.9 6.5e-08 32.7 0.2 6.1 5 0 0 5 5 5 5 Galactose oxidase, central domain Kelch_6 PF13964.6 EXF81497.1 - 3.2e-26 90.7 7.2 7.3e-11 42.0 0.8 6.5 5 1 1 6 6 6 6 Kelch motif Kelch_2 PF07646.15 EXF81497.1 - 1.9e-19 68.8 8.4 7.2e-07 28.9 0.3 6.6 6 0 0 6 6 6 5 Kelch motif Filament PF00038.21 EXF81497.1 - 0.0021 17.7 29.3 0.0021 17.7 29.3 4.1 2 1 1 4 4 4 1 Intermediate filament protein Pox_A_type_inc PF04508.12 EXF81497.1 - 9.8 6.2 7.0 2.2 8.3 0.1 3.7 4 0 0 4 4 4 0 Viral A-type inclusion protein repeat GATA PF00320.27 EXF81498.1 - 1.9e-16 59.4 2.3 3.7e-16 58.4 2.3 1.5 1 0 0 1 1 1 1 GATA zinc finger DUF1752 PF08550.10 EXF81498.1 - 1.1e-11 44.4 0.4 2.6e-11 43.1 0.4 1.7 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) SMC_N PF02463.19 EXF81499.1 - 7.9e-25 87.6 0.0 1.8e-24 86.4 0.0 1.6 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EXF81499.1 - 5.6e-17 62.9 0.2 5.6e-17 62.9 0.2 5.4 2 2 2 4 4 4 1 AAA domain AAA_15 PF13175.6 EXF81499.1 - 6.5e-13 49.1 5.9 1.2e-07 31.8 0.0 2.7 2 1 0 2 2 2 2 AAA ATPase domain AAA_21 PF13304.6 EXF81499.1 - 1.7e-05 24.8 5.8 0.021 14.6 0.0 3.8 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system CENP-F_leu_zip PF10473.9 EXF81499.1 - 0.0086 16.1 1.1 0.0086 16.1 1.1 5.8 4 2 2 6 6 6 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 AAA_29 PF13555.6 EXF81499.1 - 0.024 14.4 0.0 0.049 13.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain NPV_P10 PF05531.12 EXF81499.1 - 0.069 13.6 14.2 1.3 9.5 0.1 6.1 4 2 0 4 4 4 0 Nucleopolyhedrovirus P10 protein Pkinase PF00069.25 EXF81500.1 - 3.6e-67 226.5 0.0 5.1e-66 222.7 0.0 2.2 1 1 0 1 1 1 1 Protein kinase domain Fungal_KA1 PF16797.5 EXF81500.1 - 2e-39 134.0 0.0 4.1e-39 133.0 0.0 1.6 1 0 0 1 1 1 1 Fungal kinase associated-1 domain Pkinase_Tyr PF07714.17 EXF81500.1 - 3.1e-33 115.2 0.0 9.6e-33 113.6 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 EXF81500.1 - 0.00011 21.6 0.0 0.00017 21.0 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EXF81500.1 - 0.0012 18.8 0.0 0.015 15.2 0.0 2.3 1 1 0 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.22 EXF81500.1 - 0.003 17.2 0.2 0.055 13.1 0.1 2.4 2 0 0 2 2 2 1 RIO1 family Choline_kinase PF01633.20 EXF81500.1 - 0.015 14.9 0.1 0.036 13.7 0.1 1.6 1 0 0 1 1 1 0 Choline/ethanolamine kinase Kdo PF06293.14 EXF81500.1 - 0.017 14.5 0.0 0.037 13.4 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EXF81500.1 - 0.031 13.2 0.0 0.066 12.1 0.0 1.5 1 0 0 1 1 1 0 Haspin like kinase domain Malate_synthase PF01274.22 EXF81501.1 - 2e-228 758.9 0.0 2.3e-228 758.7 0.0 1.0 1 0 0 1 1 1 1 Malate synthase MFS_1 PF07690.16 EXF81502.1 - 7e-24 84.4 19.8 7e-24 84.4 19.8 1.4 1 1 1 2 2 2 2 Major Facilitator Superfamily DEAD PF00270.29 EXF81503.1 - 2.5e-22 79.5 0.1 2e-21 76.6 0.0 2.4 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EXF81503.1 - 6.3e-21 74.8 0.7 1.2e-16 61.1 0.0 3.3 3 0 0 3 3 3 2 Helicase conserved C-terminal domain RecQ_Zn_bind PF16124.5 EXF81503.1 - 4e-18 65.9 7.5 1.6e-17 64.0 7.5 2.2 1 0 0 1 1 1 1 RecQ zinc-binding RQC PF09382.10 EXF81503.1 - 7e-14 51.6 0.0 1.6e-13 50.4 0.0 1.7 1 0 0 1 1 1 1 RQC domain ResIII PF04851.15 EXF81503.1 - 6e-08 32.9 0.0 2e-07 31.2 0.0 1.9 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HRDC PF00570.23 EXF81503.1 - 0.0044 17.0 0.0 0.012 15.6 0.0 1.7 1 0 0 1 1 1 1 HRDC domain HSBP1 PF06825.12 EXF81503.1 - 0.046 13.6 0.8 1.7 8.6 0.2 2.6 2 0 0 2 2 2 0 Heat shock factor binding protein 1 KAR9 PF08580.10 EXF81504.1 - 1.9e-181 605.1 5.2 1.9e-181 605.1 5.2 2.7 2 1 0 2 2 2 1 Yeast cortical protein KAR9 UvrA_inter PF17760.1 EXF81504.1 - 0.039 14.0 1.5 0.11 12.5 0.7 2.0 2 0 0 2 2 2 0 UvrA interaction domain Syntaxin-6_N PF09177.11 EXF81504.1 - 0.07 13.7 2.8 2 9.0 0.0 4.0 3 1 0 3 3 3 0 Syntaxin 6, N-terminal HetR_C PF18460.1 EXF81504.1 - 0.65 10.0 2.7 0.88 9.5 0.1 2.5 2 0 0 2 2 2 0 Heterocyst differentiation regulator C-terminal Hood domain DUF4152 PF13680.6 EXF81505.1 - 0.16 11.3 0.0 9.8 5.5 0.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF4152) AAA PF00004.29 EXF81506.1 - 1.8e-42 144.9 0.0 3e-42 144.2 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 EXF81506.1 - 7.2e-12 45.1 0.1 9.3e-11 41.5 0.1 2.3 2 0 0 2 2 2 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 EXF81506.1 - 4.3e-10 39.2 0.1 8e-10 38.4 0.1 1.4 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 EXF81506.1 - 9.9e-08 32.5 0.0 6.7e-05 23.3 0.1 2.9 2 1 1 3 3 3 1 AAA ATPase domain AAA_5 PF07728.14 EXF81506.1 - 1.9e-06 27.9 0.1 3.8e-05 23.7 0.1 2.6 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 EXF81506.1 - 2.7e-06 27.6 0.0 9.2e-06 25.9 0.0 1.9 3 0 0 3 3 1 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 EXF81506.1 - 6.9e-06 25.9 0.0 1.5e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EXF81506.1 - 0.00022 21.5 0.1 0.006 16.9 0.0 2.4 1 1 1 2 2 2 1 AAA domain DUF815 PF05673.13 EXF81506.1 - 0.00034 19.9 0.0 0.00076 18.7 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_18 PF13238.6 EXF81506.1 - 0.00044 20.8 0.0 0.0021 18.6 0.0 2.2 2 1 0 2 2 2 1 AAA domain AAA_7 PF12775.7 EXF81506.1 - 0.0012 18.4 0.0 0.0023 17.4 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region TIP49 PF06068.13 EXF81506.1 - 0.0023 17.2 0.0 0.0043 16.3 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain Mg_chelatase PF01078.21 EXF81506.1 - 0.0037 16.7 0.0 0.0074 15.7 0.0 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI TsaE PF02367.17 EXF81506.1 - 0.004 17.2 0.0 0.0097 15.9 0.0 1.6 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_33 PF13671.6 EXF81506.1 - 0.0042 17.3 0.0 0.0091 16.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 EXF81506.1 - 0.0053 16.5 0.0 0.013 15.3 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein RNA_helicase PF00910.22 EXF81506.1 - 0.0061 16.9 0.0 0.012 16.0 0.0 1.5 1 0 0 1 1 1 1 RNA helicase AAA_14 PF13173.6 EXF81506.1 - 0.0065 16.5 0.0 0.016 15.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain Sigma54_activat PF00158.26 EXF81506.1 - 0.0084 15.8 0.0 0.027 14.2 0.0 1.9 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_3 PF07726.11 EXF81506.1 - 0.012 15.4 0.0 0.03 14.2 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_11 PF13086.6 EXF81506.1 - 0.017 14.9 0.7 0.26 11.0 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 EXF81506.1 - 0.019 14.7 0.0 0.057 13.1 0.0 1.9 2 0 0 2 2 1 0 AAA domain eIF-1a PF01176.19 EXF81506.1 - 0.025 14.4 0.1 0.048 13.5 0.1 1.4 1 0 0 1 1 1 0 Translation initiation factor 1A / IF-1 Prot_ATP_OB_N PF17758.1 EXF81506.1 - 0.027 14.1 0.0 0.077 12.7 0.0 1.7 1 0 0 1 1 1 0 Proteasomal ATPase OB N-terminal domain AAA_30 PF13604.6 EXF81506.1 - 0.036 13.8 0.0 0.11 12.2 0.0 1.8 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 EXF81506.1 - 0.037 13.4 0.4 0.13 11.5 0.0 2.1 3 0 0 3 3 3 0 KaiC DUF4200 PF13863.6 EXF81506.1 - 0.051 14.0 1.6 0.051 14.0 1.6 1.9 2 0 0 2 2 1 0 Domain of unknown function (DUF4200) NACHT PF05729.12 EXF81506.1 - 0.056 13.4 0.1 0.15 12.0 0.0 1.7 2 0 0 2 2 2 0 NACHT domain PhoH PF02562.16 EXF81506.1 - 0.063 12.7 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein AAA_28 PF13521.6 EXF81506.1 - 0.091 13.0 0.0 0.17 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 EXF81506.1 - 0.092 12.3 0.0 0.22 11.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 EXF81506.1 - 0.12 11.7 0.0 0.26 10.5 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin Parvo_NS1 PF01057.17 EXF81506.1 - 0.13 11.3 0.0 0.22 10.6 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 DUF3450 PF11932.8 EXF81506.1 - 0.39 10.0 2.3 0.64 9.3 2.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) AAA_23 PF13476.6 EXF81506.1 - 3.1 8.3 5.6 26 5.3 0.2 2.7 2 1 0 2 2 2 0 AAA domain SIS PF01380.22 EXF81507.1 - 1.8e-58 196.0 0.2 9.7e-32 109.6 0.1 2.3 2 0 0 2 2 2 2 SIS domain GATase_6 PF13522.6 EXF81507.1 - 1.5e-17 64.1 0.0 3.1e-17 63.0 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 EXF81507.1 - 1.2e-10 41.4 0.0 2.9e-10 40.1 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.6 EXF81507.1 - 0.001 18.1 0.0 0.0016 17.4 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferases class-II CAP18_C PF12153.8 EXF81507.1 - 0.077 12.9 0.3 0.18 11.7 0.3 1.5 1 0 0 1 1 1 0 LPS binding domain of CAP18 (C terminal) PTSIIB_sorb PF03830.15 EXF81507.1 - 0.13 12.5 0.0 0.48 10.6 0.0 1.9 1 0 0 1 1 1 0 PTS system sorbose subfamily IIB component Proteasome PF00227.26 EXF81508.1 - 2.3e-28 99.0 0.0 2.8e-28 98.7 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit HMG_box_2 PF09011.10 EXF81509.1 - 1.8e-09 38.0 0.3 1.8e-09 38.0 0.3 3.3 4 0 0 4 4 4 1 HMG-box domain HMG_box PF00505.19 EXF81509.1 - 2e-07 31.3 0.6 2e-07 31.3 0.6 3.4 3 0 0 3 3 3 2 HMG (high mobility group) box DUF3945 PF13101.6 EXF81509.1 - 0.06 13.1 0.3 0.19 11.5 0.3 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3945) Med3 PF11593.8 EXF81509.1 - 2.1 7.5 13.4 2.6 7.2 13.4 1.3 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Dicty_REP PF05086.12 EXF81509.1 - 3.3 5.6 4.7 3.5 5.5 4.7 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein 3Beta_HSD PF01073.19 EXF81511.1 - 2.7e-66 223.4 0.0 3.4e-66 223.1 0.0 1.0 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EXF81511.1 - 4.4e-32 111.4 0.4 7.4e-32 110.7 0.2 1.4 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EXF81511.1 - 3.8e-18 66.0 0.0 1.7e-15 57.3 0.0 2.3 2 0 0 2 2 2 2 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 EXF81511.1 - 3.2e-15 56.0 0.3 4.5e-15 55.5 0.3 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.12 EXF81511.1 - 1.9e-12 46.9 0.2 2.1e-09 36.9 0.0 2.1 1 1 0 2 2 2 2 Male sterility protein NAD_binding_10 PF13460.6 EXF81511.1 - 5e-12 46.1 0.1 7.1e-12 45.6 0.1 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Polysacc_synt_2 PF02719.15 EXF81511.1 - 2e-07 30.5 0.1 8.3e-07 28.4 0.2 2.0 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein NAD_binding_3 PF03447.16 EXF81511.1 - 0.0014 19.3 0.0 0.0026 18.4 0.0 1.5 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain KR PF08659.10 EXF81511.1 - 0.0015 18.5 1.7 0.01 15.7 1.7 2.2 1 1 0 1 1 1 1 KR domain adh_short PF00106.25 EXF81511.1 - 0.12 11.8 0.2 0.23 10.9 0.2 1.5 1 1 0 1 1 1 0 short chain dehydrogenase RhoGAP PF00620.27 EXF81512.1 - 5.1e-36 123.8 0.0 1.1e-35 122.7 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain LIM PF00412.22 EXF81512.1 - 1.2e-30 105.5 39.0 6.1e-11 42.4 4.6 5.0 5 0 0 5 5 5 4 LIM domain Desulfoferrod_N PF06397.12 EXF81512.1 - 0.85 9.3 2.8 0.59 9.8 0.1 2.2 2 0 0 2 2 2 0 Desulfoferrodoxin, N-terminal domain dCMP_cyt_deam_1 PF00383.23 EXF81513.1 - 3.5e-18 65.3 0.0 5e-18 64.9 0.0 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EXF81513.1 - 9.7e-15 54.5 0.0 1.2e-14 54.2 0.0 1.1 1 0 0 1 1 1 1 MafB19-like deaminase Bd3614-deam PF14439.6 EXF81513.1 - 0.012 15.7 0.9 0.08 13.0 0.9 2.0 1 1 0 1 1 1 0 Bd3614-like deaminase APOBEC2 PF18772.1 EXF81513.1 - 0.04 14.0 0.8 2.5 8.1 0.8 2.1 1 1 0 1 1 1 0 APOBEC2 NAD1 PF18778.1 EXF81513.1 - 0.095 12.8 0.8 2.9 8.0 0.3 2.1 1 1 1 2 2 2 0 Novel AID APOBEC clade 1 zf-HC5HC2H_2 PF13832.6 EXF81514.1 - 4.2e-20 71.9 0.5 4.2e-20 71.9 0.5 4.5 5 0 0 5 5 5 2 PHD-zinc-finger like domain BAH PF01426.18 EXF81514.1 - 1.2e-18 67.1 0.0 3.4e-18 65.7 0.0 1.8 1 0 0 1 1 1 1 BAH domain zf-HC5HC2H PF13771.6 EXF81514.1 - 5.4e-16 58.6 0.9 5.4e-16 58.6 0.9 5.2 4 1 0 4 4 4 1 PHD-like zinc-binding domain PHD PF00628.29 EXF81514.1 - 2.9e-10 39.9 56.3 1e-06 28.5 9.0 6.3 6 0 0 6 6 6 2 PHD-finger PHD_2 PF13831.6 EXF81514.1 - 4.6e-08 32.5 4.6 4.6e-08 32.5 4.6 5.0 7 0 0 7 7 7 2 PHD-finger Myb_DNA-binding PF00249.31 EXF81514.1 - 0.0041 17.3 1.6 0.0056 16.8 0.0 2.1 2 0 0 2 2 2 1 Myb-like DNA-binding domain C1_1 PF00130.22 EXF81514.1 - 0.0078 16.1 2.8 0.0078 16.1 2.8 6.3 6 1 1 7 7 7 2 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_2 PF03107.16 EXF81514.1 - 0.025 14.9 0.5 0.025 14.9 0.5 6.7 8 0 0 8 8 8 0 C1 domain GATA PF00320.27 EXF81514.1 - 1.8 8.2 9.0 0.34 10.6 1.1 3.6 3 0 0 3 3 3 0 GATA zinc finger DEAD PF00270.29 EXF81516.1 - 5.1e-10 39.4 0.0 1.4e-09 38.0 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EXF81516.1 - 8.6e-07 29.3 0.0 3.4e-06 27.3 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HHH_5 PF14520.6 EXF81516.1 - 0.0082 16.7 0.0 0.028 15.0 0.0 1.9 1 0 0 1 1 1 1 Helix-hairpin-helix domain BTB PF00651.31 EXF81517.1 - 3.2e-05 24.1 0.1 9e-05 22.7 0.0 1.7 2 0 0 2 2 2 1 BTB/POZ domain Phage_fiber PF03335.13 EXF81517.1 - 1.7 9.0 6.5 3.8 7.9 6.5 1.6 1 0 0 1 1 1 0 Phage tail fibre repeat COesterase PF00135.28 EXF81518.1 - 9e-59 199.7 0.0 2.5e-58 198.2 0.0 1.7 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EXF81518.1 - 1.3e-05 25.2 0.1 0.00011 22.1 0.1 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EXF81518.1 - 7.5e-05 22.3 0.0 0.00013 21.6 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 EXF81519.1 - 1e-13 51.6 0.0 3e-13 50.0 0.0 1.7 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EXF81519.1 - 4.2e-09 36.0 0.0 8.1e-09 35.1 0.0 1.5 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EXF81519.1 - 0.00074 20.2 0.0 0.0027 18.4 0.0 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S28 PF05577.12 EXF81519.1 - 0.0023 16.8 0.0 0.0054 15.6 0.0 1.6 2 0 0 2 2 2 1 Serine carboxypeptidase S28 Esterase PF00756.20 EXF81519.1 - 0.0049 16.5 0.0 0.0091 15.7 0.0 1.5 1 0 0 1 1 1 1 Putative esterase Peptidase_S9 PF00326.21 EXF81519.1 - 0.0052 16.3 0.0 0.02 14.4 0.0 1.9 1 1 0 1 1 1 1 Prolyl oligopeptidase family LIDHydrolase PF10230.9 EXF81519.1 - 0.065 12.8 0.0 0.1 12.1 0.0 1.3 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase ZapB PF06005.12 EXF81520.1 - 0.88 10.1 4.4 22 5.5 0.0 2.4 2 0 0 2 2 2 0 Cell division protein ZapB SNARE_assoc PF09335.11 EXF81521.1 - 3.8e-12 46.8 9.2 3.8e-12 46.8 9.2 2.4 2 0 0 2 2 2 1 SNARE associated Golgi protein DUF2614 PF11023.8 EXF81521.1 - 0.8 9.8 1.9 0.58 10.3 0.1 1.6 2 0 0 2 2 2 0 Zinc-ribbon containing domain DUF1771 PF08590.10 EXF81522.1 - 2.5e-15 56.6 11.6 8.5e-15 54.9 11.6 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1771) zf_CCCH_4 PF18345.1 EXF81522.1 - 3.4e-08 33.3 7.9 1e-05 25.4 0.4 2.9 2 1 0 2 2 2 2 Zinc finger domain Smr PF01713.21 EXF81522.1 - 8.4e-07 29.3 0.0 2.6e-06 27.7 0.0 1.8 1 0 0 1 1 1 1 Smr domain zf-CCCH PF00642.24 EXF81522.1 - 3e-06 27.0 3.4 0.0011 18.8 0.4 2.4 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.6 EXF81522.1 - 0.00025 21.4 4.5 0.11 13.0 0.8 2.4 2 0 0 2 2 2 2 RNA-binding, Nab2-type zinc finger zf-CCCH_4 PF18044.1 EXF81522.1 - 0.00037 20.2 11.1 0.0056 16.4 0.3 3.1 2 1 0 2 2 2 1 CCCH-type zinc finger HBS1_N PF08938.10 EXF81522.1 - 0.0052 17.1 0.0 0.014 15.7 0.0 1.6 1 0 0 1 1 1 1 HBS1 N-terminus zf-CCCH_3 PF15663.5 EXF81522.1 - 0.2 11.8 2.8 9.1 6.5 0.1 2.3 1 1 1 2 2 2 0 Zinc-finger containing family Torus PF16131.5 EXF81522.1 - 0.91 10.3 5.6 1.6 9.4 0.5 2.4 1 1 1 2 2 2 0 Torus domain Cupin_8 PF13621.6 EXF81523.1 - 2.3e-17 63.6 0.1 8.7e-16 58.4 0.1 2.2 1 1 0 1 1 1 1 Cupin-like domain JmjC PF02373.22 EXF81523.1 - 9.6e-10 38.9 0.1 4.3e-09 36.8 0.1 2.1 1 1 0 1 1 1 1 JmjC domain, hydroxylase F-box-like PF12937.7 EXF81523.1 - 3.2e-05 23.7 0.2 3.2e-05 23.7 0.2 2.2 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EXF81523.1 - 0.00038 20.3 0.1 0.001 18.9 0.1 1.8 1 0 0 1 1 1 1 F-box domain DEAD PF00270.29 EXF81524.1 - 5.7e-46 156.5 1.3 9.2e-46 155.8 1.3 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EXF81524.1 - 6e-32 110.3 0.4 8.7e-31 106.5 0.0 2.6 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EXF81524.1 - 2.6e-06 27.5 0.0 4.3e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 EXF81524.1 - 0.00018 21.3 0.1 0.00037 20.3 0.1 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EXF81524.1 - 0.00031 21.1 1.8 0.0012 19.2 0.7 2.2 2 1 0 2 2 2 1 AAA domain CMS1 PF14617.6 EXF81524.1 - 0.024 14.0 0.0 0.051 12.9 0.0 1.5 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit AAA_22 PF13401.6 EXF81524.1 - 0.031 14.5 0.9 0.19 12.0 0.9 2.2 1 1 0 1 1 1 0 AAA domain Helicase_RecD PF05127.14 EXF81524.1 - 0.058 13.3 0.0 0.12 12.3 0.0 1.6 1 0 0 1 1 1 0 Helicase UvrD-helicase PF00580.21 EXF81524.1 - 0.07 12.6 0.4 0.1 12.1 0.3 1.4 1 1 0 1 1 1 0 UvrD/REP helicase N-terminal domain Flavi_DEAD PF07652.14 EXF81524.1 - 0.079 12.9 0.2 0.38 10.7 0.2 2.2 1 1 0 1 1 1 0 Flavivirus DEAD domain IL17R_D_N PF16742.5 EXF81524.1 - 0.084 12.9 0.0 0.23 11.5 0.0 1.7 1 0 0 1 1 1 0 N-terminus of interleukin 17 receptor D fragilysinNterm PF16376.5 EXF81524.1 - 0.092 12.5 0.0 0.27 11.0 0.0 1.7 1 0 0 1 1 1 0 N-terminal domain of fragilysin tRNA-synt_1b PF00579.25 EXF81524.1 - 0.093 12.0 0.2 0.47 9.7 0.0 2.1 3 0 0 3 3 3 0 tRNA synthetases class I (W and Y) dCMP_cyt_deam_1 PF00383.23 EXF81525.1 - 3.5e-14 52.5 0.3 4.8e-14 52.1 0.3 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region dCMP_cyt_deam_2 PF08211.12 EXF81525.1 - 1.2e-08 35.2 2.5 6.4e-08 32.9 0.3 2.1 2 0 0 2 2 2 1 Cytidine and deoxycytidylate deaminase zinc-binding region XOO_2897-deam PF14440.6 EXF81525.1 - 0.00099 19.2 0.1 0.12 12.5 0.0 2.1 1 1 1 2 2 2 2 Xanthomonas XOO_2897-like deaminase LmjF365940-deam PF14421.6 EXF81525.1 - 0.0047 16.5 1.4 0.61 9.7 0.0 2.2 1 1 1 2 2 2 2 A distinct subfamily of CDD/CDA-like deaminases Fer4_13 PF13370.6 EXF81525.1 - 0.13 12.8 2.2 2.3 8.8 0.1 2.4 2 0 0 2 2 2 0 4Fe-4S single cluster domain of Ferredoxin I adh_short_C2 PF13561.6 EXF81526.1 - 1.6e-34 119.5 0.0 9.1e-34 117.0 0.0 1.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF81526.1 - 2.2e-26 92.6 0.0 3e-26 92.1 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EXF81526.1 - 5.3e-08 33.0 0.0 4e-07 30.1 0.0 2.0 2 0 0 2 2 2 1 KR domain DnaJ_C PF01556.18 EXF81527.1 - 5.8e-38 130.3 0.1 8.1e-38 129.8 0.1 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EXF81527.1 - 5.3e-26 90.5 3.1 9.1e-26 89.8 3.1 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 EXF81527.1 - 8.5e-16 58.1 20.1 1.5e-15 57.3 20.1 1.4 1 0 0 1 1 1 1 DnaJ central domain HypA PF01155.19 EXF81527.1 - 0.25 11.4 11.0 0.63 10.1 2.6 2.5 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DZR PF12773.7 EXF81527.1 - 0.95 9.5 6.5 5 7.2 0.9 2.3 2 0 0 2 2 2 0 Double zinc ribbon Anti-TRAP PF15777.5 EXF81527.1 - 1.6 8.8 17.3 0.87 9.6 3.1 2.6 1 1 1 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein zinc-ribbons_6 PF07191.12 EXF81527.1 - 3.3 7.8 8.4 3.3 7.8 2.3 2.3 2 0 0 2 2 2 0 zinc-ribbons CPSF_A PF03178.15 EXF81528.1 - 2.4e-05 23.8 0.0 0.00062 19.2 0.0 2.2 1 1 0 2 2 2 1 CPSF A subunit region PQQ_2 PF13360.6 EXF81528.1 - 0.007 16.0 0.1 0.11 12.1 0.0 2.4 2 0 0 2 2 2 1 PQQ-like domain Cytomega_UL20A PF05984.12 EXF81528.1 - 0.017 15.4 1.5 6.1 7.2 0.0 3.3 3 0 0 3 3 3 0 Cytomegalovirus UL20A protein WD40 PF00400.32 EXF81528.1 - 0.032 15.1 0.6 7.1 7.7 0.1 3.6 3 0 0 3 3 3 0 WD domain, G-beta repeat VRP3 PF03536.15 EXF81528.1 - 0.06 12.8 0.0 0.15 11.5 0.0 1.6 2 0 0 2 2 2 0 Salmonella virulence-associated 28kDa protein DUF2694 PF10904.8 EXF81528.1 - 0.11 12.5 0.0 0.55 10.3 0.0 2.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2694) Ribosomal_L10 PF00466.20 EXF81529.1 - 1.4e-22 79.7 0.1 3.4e-22 78.4 0.1 1.5 1 0 0 1 1 1 1 Ribosomal protein L10 RL10P_insert PF17777.1 EXF81529.1 - 1.6e-21 76.1 0.0 3.2e-21 75.1 0.0 1.5 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_60s PF00428.19 EXF81529.1 - 1.2e-19 70.6 6.1 1.5e-19 70.3 3.2 2.3 2 0 0 2 2 2 1 60s Acidic ribosomal protein WRNPLPNID PF15017.6 EXF81529.1 - 0.085 13.7 0.9 0.16 12.9 0.9 1.4 1 0 0 1 1 1 0 Putative WW-binding domain and destruction box MutS_V PF00488.21 EXF81530.1 - 1.6e-69 233.8 0.0 3.2e-69 232.7 0.0 1.5 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 EXF81530.1 - 1.5e-46 159.1 5.6 2.5e-46 158.3 5.6 1.4 1 0 0 1 1 1 1 MutS domain III MutS_I PF01624.20 EXF81530.1 - 7.2e-19 68.1 0.0 1.8e-18 66.8 0.0 1.7 1 0 0 1 1 1 1 MutS domain I MutS_II PF05188.17 EXF81530.1 - 1.7e-07 31.6 0.0 4e-07 30.4 0.0 1.6 1 0 0 1 1 1 1 MutS domain II AAA_27 PF13514.6 EXF81530.1 - 0.085 12.4 0.0 0.24 11.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EXF81530.1 - 0.12 12.2 1.0 0.35 10.6 0.1 2.2 1 1 1 2 2 2 0 P-loop containing region of AAA domain AAA_23 PF13476.6 EXF81530.1 - 0.21 12.1 0.0 0.39 11.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain TFIIA PF03153.13 EXF81531.1 - 1.5e-05 25.2 5.9 2.6e-05 24.4 5.9 1.3 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Drc1-Sld2 PF11719.8 EXF81531.1 - 0.054 13.0 10.4 0.12 11.9 10.4 1.5 1 1 0 1 1 1 0 DNA replication and checkpoint protein Astro_capsid_p PF12226.8 EXF81531.1 - 0.078 12.1 4.1 0.1 11.7 4.1 1.3 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Thioredoxin_12 PF18400.1 EXF81531.1 - 0.24 11.2 1.1 0.44 10.4 1.1 1.4 1 0 0 1 1 1 0 Thioredoxin-like domain Nop14 PF04147.12 EXF81531.1 - 0.46 8.6 8.1 0.57 8.3 8.1 1.3 1 0 0 1 1 1 0 Nop14-like family DUF4813 PF16072.5 EXF81531.1 - 7.4 6.1 9.9 9.9 5.7 9.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4813) Glyco_hydro_38N PF01074.22 EXF81532.1 - 4.4e-88 295.4 1.5 6.8e-88 294.8 1.5 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.13 EXF81532.1 - 4.8e-58 196.7 0.5 4e-57 193.7 0.3 2.1 2 0 0 2 2 2 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.11 EXF81532.1 - 1.3e-27 95.7 0.0 3.1e-27 94.6 0.0 1.7 1 0 0 1 1 1 1 Alpha mannosidase middle domain Glyco_hydro38C2 PF17677.1 EXF81532.1 - 3e-12 46.5 0.0 1.8e-11 44.0 0.0 2.4 1 1 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal beta sandwich domain TubC_N PF18563.1 EXF81532.1 - 0.11 12.5 0.0 9.4 6.3 0.0 2.5 2 0 0 2 2 2 0 TubC N-terminal docking domain Pkinase PF00069.25 EXF81533.1 - 1.4e-32 113.1 0.0 1.3e-19 70.6 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EXF81533.1 - 2.1e-11 43.6 0.0 0.0011 18.3 0.0 3.1 3 0 0 3 3 3 3 Protein tyrosine kinase APH PF01636.23 EXF81533.1 - 0.0029 17.6 0.0 0.27 11.1 0.0 2.3 2 0 0 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.6 EXF81533.1 - 0.0048 16.3 0.0 0.44 9.8 0.0 2.2 2 0 0 2 2 2 2 Kinase-like CAP_GLY PF01302.25 EXF81534.1 - 1.6e-15 56.9 0.1 3.4e-15 55.8 0.1 1.6 1 0 0 1 1 1 1 CAP-Gly domain CLIP1_ZNF PF16641.5 EXF81534.1 - 2.4e-07 30.4 11.0 0.0012 18.6 1.1 2.4 2 0 0 2 2 2 2 CLIP1 zinc knuckle AAA_13 PF13166.6 EXF81534.1 - 0.00095 17.9 4.4 0.00095 17.9 4.4 2.1 1 1 1 2 2 2 1 AAA domain DUF3584 PF12128.8 EXF81534.1 - 0.0094 13.5 21.7 0.013 13.0 21.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) NPV_P10 PF05531.12 EXF81534.1 - 0.013 15.9 4.3 2.9 8.4 0.1 3.1 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein TMF_DNA_bd PF12329.8 EXF81534.1 - 0.016 15.1 29.2 0.29 11.1 2.2 5.3 5 0 0 5 5 5 0 TATA element modulatory factor 1 DNA binding BLOC1_2 PF10046.9 EXF81534.1 - 0.45 10.9 11.7 0.089 13.1 1.8 3.2 4 0 0 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Fez1 PF06818.15 EXF81534.1 - 0.73 10.3 30.4 0.46 10.9 12.5 3.2 2 1 1 3 3 3 0 Fez1 DUF948 PF06103.11 EXF81534.1 - 0.84 9.9 2.8 1.4 9.3 0.3 2.6 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) KIP1 PF07765.12 EXF81534.1 - 0.91 9.7 5.5 0.36 11.0 1.6 2.3 2 0 0 2 2 2 0 KIP1-like protein Spc7 PF08317.11 EXF81534.1 - 1.3 7.9 26.7 0.91 8.3 8.5 3.3 2 1 0 3 3 3 0 Spc7 kinetochore protein Glutaredoxin2_C PF04399.13 EXF81534.1 - 1.3 8.8 3.3 5.2 6.9 0.4 2.4 2 0 0 2 2 2 0 Glutaredoxin 2, C terminal domain zf_PR_Knuckle PF18445.1 EXF81534.1 - 1.6 8.6 3.3 6.8 6.6 0.1 2.4 2 0 0 2 2 2 0 PR zinc knuckle motif DUF812 PF05667.11 EXF81534.1 - 2.4 6.9 27.9 0.12 11.2 16.3 3.0 1 1 1 2 2 2 0 Protein of unknown function (DUF812) HrpB7 PF09486.10 EXF81534.1 - 3.1 8.2 28.0 3.2 8.1 0.7 3.6 3 0 0 3 3 3 0 Bacterial type III secretion protein (HrpB7) Fib_alpha PF08702.10 EXF81534.1 - 3.5 7.8 13.7 3.6 7.8 3.6 3.3 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family DUF4407 PF14362.6 EXF81534.1 - 4.8 6.5 23.5 0.38 10.1 7.1 2.9 1 1 3 4 4 4 0 Domain of unknown function (DUF4407) EMP24_GP25L PF01105.24 EXF81534.1 - 7.5 6.4 7.4 4 7.4 1.2 2.5 2 0 0 2 2 2 0 emp24/gp25L/p24 family/GOLD Nop14 PF04147.12 EXF81536.1 - 7.9e-297 987.2 33.8 1e-296 986.8 33.8 1.1 1 0 0 1 1 1 1 Nop14-like family DUF4187 PF13821.6 EXF81537.1 - 8.6e-23 79.9 4.3 2.6e-22 78.4 4.3 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF4187) G-patch PF01585.23 EXF81537.1 - 0.00021 21.1 14.5 0.0011 18.8 14.5 2.1 1 1 0 1 1 1 1 G-patch domain DUF4301 PF14134.6 EXF81537.1 - 0.13 11.1 0.0 0.17 10.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4301) DUF2967 PF11179.8 EXF81537.1 - 3.3 5.7 9.3 3.9 5.5 9.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2967) PPR_2 PF13041.6 EXF81538.1 - 8.7e-10 38.6 0.0 0.00011 22.4 0.0 4.5 4 0 0 4 4 4 2 PPR repeat family PPR PF01535.20 EXF81538.1 - 0.00019 21.4 1.3 1.8 9.0 0.0 4.9 5 0 0 5 5 5 2 PPR repeat PPR_3 PF13812.6 EXF81538.1 - 0.023 14.7 0.0 3.1 7.9 0.0 3.0 3 0 0 3 3 3 0 Pentatricopeptide repeat domain KIX_2 PF16987.5 EXF81538.1 - 0.077 13.0 0.0 0.32 11.0 0.0 2.1 1 0 0 1 1 1 0 KIX domain ECM11 PF15463.6 EXF81538.1 - 5 7.7 6.6 8.9 6.9 0.1 3.3 4 0 0 4 4 4 0 Extracellular mutant protein 11 RTC_insert PF05189.13 EXF81539.1 - 7.7e-30 103.5 0.1 1.4e-29 102.6 0.1 1.4 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain RTC PF01137.21 EXF81539.1 - 3.7e-28 98.2 0.2 4.6e-28 97.9 0.2 1.0 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase DUF1746 PF08508.10 EXF81540.1 - 9.8e-41 138.7 0.2 1.3e-40 138.3 0.2 1.2 1 0 0 1 1 1 1 Fungal domain of unknown function (DUF1746) REV PF00424.18 EXF81540.1 - 0.16 12.0 3.6 0.65 10.1 0.4 2.3 2 0 0 2 2 2 0 REV protein (anti-repression trans-activator protein) FXR_C1 PF16096.5 EXF81540.1 - 2 8.6 10.8 2 8.7 0.7 2.4 2 0 0 2 2 2 0 Fragile X-related 1 protein C-terminal region 2 tRNA-synt_2d PF01409.20 EXF81541.1 - 6.9e-86 287.7 0.0 9.8e-86 287.2 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) PheRS_DBD3 PF18553.1 EXF81541.1 - 4.3e-17 62.2 0.5 9.7e-17 61.0 0.5 1.7 1 0 0 1 1 1 1 PheRS DNA binding domain 3 tRNA_synthFbeta PF17759.1 EXF81541.1 - 6.8e-07 28.9 0.0 0.0031 17.0 0.0 3.1 3 0 0 3 3 3 2 Phenylalanyl tRNA synthetase beta chain CLM domain PheRS_DBD2 PF18554.1 EXF81541.1 - 8.8e-06 25.6 1.9 2.4e-05 24.2 1.9 1.8 1 0 0 1 1 1 1 PheRS DNA binding domain 2 tRNA-synt_2 PF00152.20 EXF81541.1 - 3.1e-05 23.2 0.8 0.0015 17.6 0.0 3.1 4 0 0 4 4 4 1 tRNA synthetases class II (D, K and N) tRNA-synt_2b PF00587.25 EXF81541.1 - 0.021 14.8 0.0 0.037 14.0 0.0 1.5 1 0 0 1 1 1 0 tRNA synthetase class II core domain (G, H, P, S and T) ESP PF16590.5 EXF81541.1 - 1.1 9.6 3.8 4.9 7.5 0.3 2.6 3 0 0 3 3 3 0 Exocrine gland-secreting peptide CPSase_L_D2 PF02786.17 EXF81542.1 - 9.6e-108 358.5 0.0 1.2e-83 279.7 0.0 2.3 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_D3 PF02787.19 EXF81542.1 - 1.1e-39 135.6 0.1 3.2e-39 134.0 0.1 1.9 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain ATP-grasp PF02222.22 EXF81542.1 - 2.2e-21 76.2 0.0 1.1e-10 41.3 0.0 2.5 2 0 0 2 2 2 2 ATP-grasp domain Dala_Dala_lig_C PF07478.13 EXF81542.1 - 1.6e-18 67.0 1.6 4.1e-08 33.0 0.0 2.6 3 0 0 3 3 3 2 D-ala D-ala ligase C-terminus ATPgrasp_Ter PF15632.6 EXF81542.1 - 8.8e-11 41.7 0.0 0.00063 19.5 0.0 2.8 3 0 0 3 3 3 2 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_3 PF02655.14 EXF81542.1 - 1e-05 25.6 0.4 0.23 11.5 0.0 3.2 3 0 0 3 3 3 2 ATP-grasp domain GARS_A PF01071.19 EXF81542.1 - 1e-05 25.4 2.3 0.0067 16.2 0.1 2.8 3 0 0 3 3 3 2 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ATP-grasp_5 PF13549.6 EXF81542.1 - 1.7e-05 24.4 0.0 0.25 10.8 0.0 2.7 2 0 0 2 2 2 2 ATP-grasp domain RimK PF08443.11 EXF81542.1 - 1.7e-05 24.5 0.0 0.021 14.5 0.0 2.6 2 0 0 2 2 2 2 RimK-like ATP-grasp domain ATP-grasp_4 PF13535.6 EXF81542.1 - 0.00063 19.4 0.0 0.0083 15.7 0.0 2.6 2 0 0 2 2 2 1 ATP-grasp domain NPL4 PF05021.15 EXF81543.1 - 1.2e-136 455.1 0.0 1.6e-136 454.6 0.0 1.2 1 0 0 1 1 1 1 NPL4 family zf-NPL4 PF05020.15 EXF81543.1 - 1.6e-69 232.6 0.1 2.6e-69 231.9 0.1 1.3 1 0 0 1 1 1 1 NPL4 family, putative zinc binding region UN_NPL4 PF11543.8 EXF81543.1 - 0.0026 18.2 0.0 0.011 16.1 0.0 2.0 1 1 0 1 1 1 1 Nuclear pore localisation protein NPL4 Sec66 PF09802.9 EXF81544.1 - 4.8e-81 270.6 0.7 5.7e-81 270.4 0.7 1.1 1 0 0 1 1 1 1 Preprotein translocase subunit Sec66 DUF3848 PF12959.7 EXF81544.1 - 0.027 14.5 0.2 0.081 13.0 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3848) PEP-utilisers_N PF05524.13 EXF81544.1 - 0.17 12.1 1.7 0.25 11.5 1.4 1.4 1 1 0 1 1 1 0 PEP-utilising enzyme, N-terminal PaREP1 PF05942.11 EXF81544.1 - 1.4 8.8 4.2 1.8 8.5 0.7 2.1 1 1 1 2 2 2 0 Archaeal PaREP1/PaREP8 family ORC3_N PF07034.11 EXF81546.1 - 6.1e-38 130.7 2.3 1e-35 123.4 2.3 2.2 1 1 0 1 1 1 1 Origin recognition complex (ORC) subunit 3 N-terminus ORC_WH_C PF18137.1 EXF81546.1 - 3.1e-25 88.9 0.2 3.8e-22 78.9 0.2 2.5 1 1 0 1 1 1 1 Origin recognition complex winged helix C-terminal Pox_I6 PF04595.13 EXF81546.1 - 0.052 12.5 0.0 0.094 11.7 0.0 1.3 1 0 0 1 1 1 0 Poxvirus I6-like family ApoC-I PF04691.12 EXF81546.1 - 0.22 11.5 0.9 11 6.1 0.1 2.6 2 0 0 2 2 2 0 Apolipoprotein C-I (ApoC-1) PWWP PF00855.17 EXF81547.1 - 8.9e-16 58.1 0.0 8.9e-16 58.1 0.0 4.3 3 1 1 4 4 4 1 PWWP domain Med26 PF08711.11 EXF81547.1 - 0.00055 19.9 0.3 0.0015 18.5 0.3 1.8 1 0 0 1 1 1 1 TFIIS helical bundle-like domain Sec63 PF02889.16 EXF81548.1 - 7.2e-165 546.4 0.5 2.3e-92 308.8 0.0 2.3 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.29 EXF81548.1 - 6.7e-50 169.3 0.1 1.6e-28 99.6 0.0 3.3 4 0 0 4 4 4 2 DEAD/DEAH box helicase Helicase_PWI PF18149.1 EXF81548.1 - 3.3e-34 117.4 1.8 9.7e-34 115.9 1.8 1.9 1 0 0 1 1 1 1 N-terminal helicase PWI domain ResIII PF04851.15 EXF81548.1 - 1e-24 87.5 0.0 1.5e-13 51.1 0.0 2.6 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EXF81548.1 - 1.2e-10 41.7 0.0 1.1e-07 32.1 0.0 3.7 2 2 0 2 2 2 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 EXF81548.1 - 1.8e-06 28.3 0.2 0.018 15.3 0.0 3.5 2 2 0 2 2 2 2 AAA domain T2SSE PF00437.20 EXF81548.1 - 0.0062 15.6 0.0 2 7.4 0.0 2.5 2 0 0 2 2 2 2 Type II/IV secretion system protein PhoH PF02562.16 EXF81548.1 - 0.02 14.3 0.0 0.89 9.0 0.0 2.5 2 0 0 2 2 2 0 PhoH-like protein UvrD-helicase PF00580.21 EXF81548.1 - 0.093 12.2 0.9 3.5 7.0 0.0 2.9 3 0 0 3 3 3 0 UvrD/REP helicase N-terminal domain AAA_19 PF13245.6 EXF81548.1 - 0.14 12.4 0.0 27 5.1 0.0 2.7 2 0 0 2 2 2 0 AAA domain BUD22 PF09073.10 EXF81548.1 - 0.23 10.8 14.7 0.45 9.8 14.7 1.4 1 0 0 1 1 1 0 BUD22 SDA1 PF05285.12 EXF81548.1 - 6.9 6.0 22.8 16 4.8 22.8 1.6 1 0 0 1 1 1 0 SDA1 Apo-CII PF05355.11 EXF81549.1 - 0.065 13.4 0.1 7.2 6.8 0.0 3.0 3 0 0 3 3 3 0 Apolipoprotein C-II 3H PF02829.14 EXF81549.1 - 0.1 12.9 1.5 19 5.6 0.3 2.7 2 0 0 2 2 2 0 3H domain Rep_fac_C PF08542.11 EXF81550.1 - 1.9e-21 76.3 0.0 3.7e-21 75.3 0.0 1.5 1 0 0 1 1 1 1 Replication factor C C-terminal domain AAA PF00004.29 EXF81550.1 - 6.7e-17 62.2 0.0 2.4e-16 60.4 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 EXF81550.1 - 7.6e-13 48.6 0.0 5.4e-12 45.8 0.0 2.1 1 1 0 1 1 1 1 DNA polymerase III, delta subunit Rad17 PF03215.15 EXF81550.1 - 2.6e-09 37.3 0.0 5.9e-09 36.1 0.0 1.7 1 1 0 1 1 1 1 Rad17 P-loop domain RuvB_N PF05496.12 EXF81550.1 - 4.6e-06 26.5 0.1 1.8e-05 24.5 0.0 2.0 3 0 0 3 3 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EXF81550.1 - 2e-05 25.0 0.0 0.00057 20.3 0.0 2.5 1 1 1 2 2 2 1 AAA ATPase domain AAA_assoc_2 PF16193.5 EXF81550.1 - 3.4e-05 24.1 0.1 9.6e-05 22.7 0.1 1.8 1 0 0 1 1 1 1 AAA C-terminal domain AAA_11 PF13086.6 EXF81550.1 - 5.7e-05 23.0 0.1 0.00012 22.0 0.1 1.7 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EXF81550.1 - 6.2e-05 23.3 0.0 0.0011 19.2 0.0 2.5 1 1 0 1 1 1 1 AAA domain DNA_pol3_delta PF06144.13 EXF81550.1 - 7e-05 22.7 0.0 0.00014 21.7 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase III, delta subunit Mg_chelatase PF01078.21 EXF81550.1 - 0.00031 20.2 0.0 0.014 14.8 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_14 PF13173.6 EXF81550.1 - 0.00046 20.2 0.0 0.00096 19.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EXF81550.1 - 0.0027 18.0 0.0 0.022 15.1 0.0 2.2 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EXF81550.1 - 0.0033 17.1 0.0 0.012 15.3 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 EXF81550.1 - 0.0035 17.1 0.0 0.011 15.5 0.0 1.8 1 1 0 1 1 1 1 AAA domain DUF815 PF05673.13 EXF81550.1 - 0.0035 16.5 0.0 0.0056 15.9 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) DUF2075 PF09848.9 EXF81550.1 - 0.004 16.4 0.0 0.0084 15.4 0.0 1.5 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_5 PF07728.14 EXF81550.1 - 0.0055 16.7 0.1 0.025 14.6 0.1 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_28 PF13521.6 EXF81550.1 - 0.0066 16.7 0.0 0.013 15.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 EXF81550.1 - 0.0068 15.9 0.0 0.011 15.2 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region ResIII PF04851.15 EXF81550.1 - 0.015 15.3 0.0 0.27 11.2 0.0 2.2 1 1 1 2 2 2 0 Type III restriction enzyme, res subunit AAA_18 PF13238.6 EXF81550.1 - 0.027 15.0 0.0 0.06 13.9 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_23 PF13476.6 EXF81550.1 - 0.03 14.8 0.0 0.046 14.2 0.0 1.2 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EXF81550.1 - 0.036 14.4 0.0 0.081 13.3 0.0 1.7 1 1 0 1 1 1 0 RNA helicase AAA_3 PF07726.11 EXF81550.1 - 0.048 13.5 0.0 0.28 11.0 0.0 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DEAD PF00270.29 EXF81550.1 - 0.053 13.3 0.7 1.3 8.8 0.0 2.8 2 1 0 3 3 3 0 DEAD/DEAH box helicase PhoH PF02562.16 EXF81550.1 - 0.07 12.6 0.1 2.3 7.6 0.0 2.5 2 0 0 2 2 2 0 PhoH-like protein AAA_33 PF13671.6 EXF81550.1 - 0.13 12.4 0.0 0.28 11.3 0.0 1.7 1 1 0 1 1 1 0 AAA domain UQ_con PF00179.26 EXF81551.1 - 3.7e-44 149.8 0.0 3.7e-29 101.2 0.0 2.3 2 0 0 2 2 2 2 Ubiquitin-conjugating enzyme FDC-SP PF15215.6 EXF81551.1 - 0.044 14.3 0.4 0.33 11.5 0.0 2.3 2 0 0 2 2 2 0 Follicular dendritic cell secreted peptide CBM32 PF18344.1 EXF81551.1 - 0.059 13.2 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 Carbohydrate binding module family 32 TcpQ PF10671.9 EXF81551.1 - 0.094 12.8 0.1 0.23 11.6 0.1 1.6 1 0 0 1 1 1 0 Toxin co-regulated pilus biosynthesis protein Q DUF2417 PF10329.9 EXF81554.1 - 1.6e-78 263.4 2.1 2e-78 263.1 2.1 1.1 1 0 0 1 1 1 1 Region of unknown function (DUF2417) DUF2070 PF09843.9 EXF81554.1 - 0.12 10.7 11.1 0.16 10.2 11.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) HTH_35 PF13693.6 EXF81554.1 - 0.12 12.4 0.0 0.34 11.0 0.0 1.7 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding Oxysterol_BP PF01237.18 EXF81556.1 - 8e-89 298.1 0.1 3.1e-78 263.2 0.0 2.0 1 1 1 2 2 2 2 Oxysterol-binding protein zf-CCCH PF00642.24 EXF81557.1 - 1.2e-08 34.6 18.6 5.3e-07 29.4 2.6 3.2 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 EXF81557.1 - 0.0058 17.3 3.1 0.4 11.4 0.2 2.4 2 0 0 2 2 2 2 Torus domain zf_CCCH_4 PF18345.1 EXF81557.1 - 0.012 15.6 2.9 0.012 15.6 2.9 3.3 3 0 0 3 3 3 0 Zinc finger domain RRM_1 PF00076.22 EXF81557.1 - 0.014 15.2 0.0 0.021 14.6 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCCH_3 PF15663.5 EXF81557.1 - 0.057 13.6 1.8 0.37 11.0 0.1 2.3 2 0 0 2 2 2 0 Zinc-finger containing family ELMO_CED12 PF04727.13 EXF81558.1 - 3.8e-50 170.4 0.0 9.3e-50 169.2 0.0 1.6 2 0 0 2 2 2 1 ELMO/CED-12 family PH_12 PF16457.5 EXF81558.1 - 3.7e-41 140.8 0.1 7.4e-41 139.8 0.1 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain DUF3361 PF11841.8 EXF81558.1 - 3.3e-13 49.9 0.1 1.2e-12 48.1 0.0 2.0 2 1 0 2 2 2 1 Domain of unknown function (DUF3361) RPN1_RPN2_N PF17781.1 EXF81558.1 - 0.063 12.7 0.0 0.14 11.5 0.0 1.6 1 0 0 1 1 1 0 RPN1/RPN2 N-terminal domain Pirin PF02678.16 EXF81559.1 - 9.6e-29 99.5 0.1 1e-27 96.2 0.1 2.1 2 0 0 2 2 2 1 Pirin Pirin_C PF05726.13 EXF81559.1 - 2.6e-25 88.8 0.1 1.5e-24 86.3 0.1 1.9 2 0 0 2 2 2 1 Pirin C-terminal cupin domain Cupin_2 PF07883.11 EXF81559.1 - 1.3e-08 34.4 3.4 7e-05 22.5 1.5 2.3 2 0 0 2 2 2 2 Cupin domain Cupin_3 PF05899.12 EXF81559.1 - 0.032 13.9 0.2 1.6 8.5 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF861) zf-GRF PF06839.12 EXF81560.1 - 2.4e-09 37.2 8.2 4.3e-09 36.3 8.2 1.4 1 0 0 1 1 1 1 GRF zinc finger PKcGMP_CC PF16808.5 EXF81560.1 - 0.0036 17.1 0.4 0.0065 16.3 0.4 1.5 1 0 0 1 1 1 1 Coiled-coil N-terminus of cGMP-dependent protein kinase TMF_DNA_bd PF12329.8 EXF81560.1 - 0.005 16.8 0.3 0.0099 15.9 0.3 1.5 1 0 0 1 1 1 1 TATA element modulatory factor 1 DNA binding DUF1204 PF06721.11 EXF81560.1 - 0.017 14.6 2.0 0.036 13.5 2.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1204) Csm1_N PF18504.1 EXF81560.1 - 0.1 12.9 0.9 0.21 12.0 0.9 1.4 1 0 0 1 1 1 0 Csm1 N-terminal domain DUF5643 PF18705.1 EXF81560.1 - 0.59 10.1 2.3 0.76 9.8 0.2 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5643) DUF3818 PF12825.7 EXF81561.1 - 2.7e-130 434.3 4.1 4.4e-130 433.6 4.1 1.3 1 0 0 1 1 1 1 Domain of unknown function in PX-proteins (DUF3818) PXB PF12828.7 EXF81561.1 - 1.1e-39 135.4 0.5 1.1e-39 135.4 0.5 1.8 2 0 0 2 2 2 1 PX-associated PX PF00787.24 EXF81561.1 - 2.1e-16 59.9 0.0 1.5e-15 57.2 0.0 2.5 2 1 0 2 2 2 1 PX domain Myc_N PF01056.18 EXF81561.1 - 0.0057 16.6 0.5 0.013 15.4 0.5 1.6 1 0 0 1 1 1 1 Myc amino-terminal region Cwf_Cwc_15 PF04889.12 EXF81561.1 - 0.035 13.8 5.7 0.1 12.3 5.7 1.7 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein PCAF_N PF06466.11 EXF81561.1 - 1.5 8.3 4.3 4.4 6.8 0.1 2.6 3 0 0 3 3 3 0 PCAF (P300/CBP-associated factor) N-terminal domain SASRP1 PF15160.6 EXF81562.1 - 0.071 12.8 0.0 0.071 12.8 0.0 1.8 2 0 0 2 2 2 0 Spermatogenesis-associated serine-rich protein 1 DotU PF09850.9 EXF81562.1 - 0.36 10.5 4.7 0.58 9.8 0.5 2.6 2 1 0 2 2 2 0 Type VI secretion system protein DotU Fib_alpha PF08702.10 EXF81562.1 - 0.39 10.9 2.0 1.3 9.2 0.2 2.4 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family Draxin PF15550.6 EXF81562.1 - 4.4 7.1 7.6 7 6.4 7.6 1.3 1 0 0 1 1 1 0 Draxin SelP_N PF04592.14 EXF81562.1 - 6.9 6.0 9.2 3.1 7.1 2.6 2.2 2 0 0 2 2 2 0 Selenoprotein P, N terminal region Cgr1 PF03879.14 EXF81563.1 - 8.6e-35 119.4 31.6 9.8e-35 119.2 31.6 1.0 1 0 0 1 1 1 1 Cgr1 family Prismane PF03063.20 EXF81563.1 - 0.63 8.7 5.9 0.71 8.5 5.9 1.0 1 0 0 1 1 1 0 Prismane/CO dehydrogenase family RR_TM4-6 PF06459.12 EXF81563.1 - 3.5 7.4 16.5 3.7 7.3 16.5 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SR-25 PF10500.9 EXF81564.1 - 0.001 18.7 10.8 0.001 18.7 10.8 3.0 3 0 0 3 3 3 1 Nuclear RNA-splicing-associated protein UQ_con PF00179.26 EXF81565.1 - 2.6e-30 104.9 0.0 3.4e-30 104.5 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EXF81565.1 - 0.17 12.2 0.0 0.21 11.9 0.0 1.2 1 0 0 1 1 1 0 RWD domain Anp1 PF03452.14 EXF81566.1 - 2e-109 365.1 0.0 2.4e-109 364.8 0.0 1.0 1 0 0 1 1 1 1 Anp1 Glycos_transf_2 PF00535.26 EXF81566.1 - 0.024 14.4 0.0 0.041 13.7 0.0 1.3 1 0 0 1 1 1 0 Glycosyl transferase family 2 RRM_1 PF00076.22 EXF81567.1 - 6.2e-17 61.2 0.0 1e-16 60.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication PF13865.6 EXF81567.1 - 0.00086 19.8 20.7 0.00086 19.8 20.7 5.6 4 2 3 7 7 7 1 C-terminal duplication domain of Friend of PRMT1 TFIIF_alpha PF05793.12 EXF81568.1 - 5.6 5.4 10.6 6.9 5.1 10.6 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DUF1932 PF09130.11 EXF81569.1 - 3.5e-26 91.0 0.1 8e-26 89.8 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1932) NAD_binding_2 PF03446.15 EXF81569.1 - 4.9e-08 33.3 0.0 8.2e-08 32.6 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 EXF81569.1 - 4.4e-07 30.4 0.1 1.2e-06 29.0 0.1 1.7 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent 3HCDH_N PF02737.18 EXF81569.1 - 0.002 18.0 0.0 0.0034 17.3 0.0 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 EXF81569.1 - 0.035 13.5 0.0 0.055 12.8 0.0 1.2 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain YjeF_N PF03853.15 EXF81569.1 - 0.12 12.3 0.0 0.2 11.5 0.0 1.3 1 0 0 1 1 1 0 YjeF-related protein N-terminus tRNA-synt_1 PF00133.22 EXF81571.1 - 4.3e-217 722.1 0.0 5.5e-216 718.5 0.0 2.2 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 EXF81571.1 - 2.5e-32 111.9 0.1 1.2e-31 109.8 0.1 2.2 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA tRNA-synt_1_2 PF13603.6 EXF81571.1 - 7.6e-12 45.1 0.1 1.7e-08 34.2 0.0 2.9 1 1 1 2 2 2 2 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1g PF09334.11 EXF81571.1 - 1.5e-11 43.7 0.0 0.0002 20.3 0.0 4.2 4 1 0 4 4 4 3 tRNA synthetases class I (M) Val_tRNA-synt_C PF10458.9 EXF81571.1 - 0.0071 16.6 7.8 0.0071 16.6 7.8 3.7 3 0 0 3 3 3 1 Valyl tRNA synthetase tRNA binding arm SHR3_chaperone PF08229.11 EXF81572.1 - 1e-76 256.2 0.0 1.1e-76 256.0 0.0 1.0 1 0 0 1 1 1 1 ER membrane protein SH3 DUF2157 PF09925.9 EXF81572.1 - 0.095 12.5 0.3 13 5.5 0.2 2.6 2 1 0 2 2 2 0 Predicted membrane protein (DUF2157) DUF5453 PF17534.2 EXF81572.1 - 0.98 9.4 6.4 0.33 10.9 1.1 2.4 2 1 1 3 3 3 0 Family of unknown function (DUF5453) AAA_11 PF13086.6 EXF81574.1 - 2.8e-49 168.3 1.0 1.3e-46 159.5 0.2 2.8 2 1 0 2 2 2 1 AAA domain AAA_12 PF13087.6 EXF81574.1 - 2.6e-46 157.8 0.0 1.1e-45 155.8 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EXF81574.1 - 0.00019 21.2 0.1 0.78 9.4 0.0 2.9 2 1 1 3 3 3 2 AAA domain DUF2075 PF09848.9 EXF81574.1 - 0.014 14.6 0.1 0.028 13.7 0.1 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Prot_ATP_ID_OB PF16450.5 EXF81574.1 - 0.017 15.1 0.0 0.05 13.6 0.0 1.8 1 0 0 1 1 1 0 Proteasomal ATPase OB C-terminal domain Viral_helicase1 PF01443.18 EXF81574.1 - 0.068 12.9 0.0 0.16 11.7 0.0 1.6 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase 4HB_MCP_1 PF12729.7 EXF81574.1 - 0.089 12.3 0.1 0.17 11.4 0.1 1.3 1 0 0 1 1 1 0 Four helix bundle sensory module for signal transduction DUF202 PF02656.15 EXF81575.1 - 4.5e-22 78.3 1.1 4.5e-22 78.3 1.1 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF202) CAP_N PF01213.19 EXF81575.1 - 2.2 7.7 17.3 4.8 6.6 17.3 1.6 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal zf-C2H2 PF00096.26 EXF81578.1 - 1.4e-10 41.0 20.5 3.2e-06 27.3 2.3 3.3 3 0 0 3 3 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EXF81578.1 - 1.9e-08 34.4 14.3 1.4e-07 31.6 6.1 3.4 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 EXF81578.1 - 3.1e-07 30.6 15.5 0.00098 19.8 1.3 3.3 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EXF81578.1 - 2.9e-06 27.4 5.1 0.0014 18.8 0.7 2.5 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EXF81578.1 - 3.1e-06 27.4 6.0 0.00011 22.5 0.3 2.8 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 EXF81578.1 - 0.0024 17.8 11.3 0.025 14.6 2.9 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf_C2H2_ZHX PF18387.1 EXF81578.1 - 0.0032 17.1 4.7 0.13 11.9 0.2 2.5 1 1 1 2 2 2 2 Zinc-fingers and homeoboxes C2H2 finger domain zf_UBZ PF18439.1 EXF81578.1 - 0.22 11.1 3.4 5.7 6.6 0.4 2.9 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger zf-C2H2_3rep PF18868.1 EXF81578.1 - 0.25 12.0 4.4 1.6 9.4 0.6 2.6 1 1 1 2 2 2 0 Zinc finger C2H2-type, 3 repeats zf-C2H2_2 PF12756.7 EXF81578.1 - 1 9.8 5.0 16 5.9 0.4 2.4 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-BED PF02892.15 EXF81578.1 - 1.1 9.3 7.7 0.67 10.0 3.4 2.3 1 1 1 2 2 2 0 BED zinc finger Zn-ribbon_8 PF09723.10 EXF81578.1 - 1.6 8.9 5.9 7.5 6.8 0.9 2.9 1 1 1 2 2 2 0 Zinc ribbon domain zf-C2H2_11 PF16622.5 EXF81578.1 - 5.5 6.8 13.1 1.5 8.6 0.2 3.1 3 0 0 3 3 3 0 zinc-finger C2H2-type DUF629 PF04780.12 EXF81578.1 - 8.9 4.7 6.3 15 4.0 0.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF629) zf-C2HE PF16278.5 EXF81578.1 - 9.9 6.7 7.8 1.8e+02 2.7 7.8 2.5 1 1 0 1 1 1 0 C2HE / C2H2 / C2HC zinc-binding finger Diphthami_syn_2 PF01902.17 EXF81579.1 - 2.2e-20 73.1 0.0 6.7e-16 58.5 0.0 3.6 3 1 0 3 3 3 3 Diphthamide synthase Ribonuc_L-PSP PF01042.21 EXF81579.1 - 3.6e-11 43.1 0.1 1e-07 31.9 0.0 3.6 3 1 0 3 3 3 2 Endoribonuclease L-PSP GGDEF_2 PF17853.1 EXF81579.1 - 0.092 13.0 0.0 0.6 10.4 0.0 2.4 2 0 0 2 2 2 0 GGDEF-like domain Acyl_transf_3 PF01757.22 EXF81580.1 - 1.1e-25 90.4 33.3 1.5e-25 90.0 33.3 1.2 1 0 0 1 1 1 1 Acyltransferase family DUF5487 PF17589.2 EXF81580.1 - 0.041 14.1 0.1 0.085 13.1 0.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5487) Antimicrobial_5 PF08026.11 EXF81581.1 - 0.24 11.5 4.2 0.61 10.2 0.1 2.5 2 0 0 2 2 2 0 Bee antimicrobial peptide DUF2970 PF11174.8 EXF81581.1 - 0.58 10.1 2.3 1.4 8.8 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2970) U-box PF04564.15 EXF81582.1 - 1.3e-18 66.9 0.0 2.5e-18 66.0 0.0 1.5 1 0 0 1 1 1 1 U-box domain TPR_2 PF07719.17 EXF81582.1 - 5.5e-10 38.6 6.7 0.00014 21.7 0.2 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 EXF81582.1 - 2e-07 30.6 4.7 0.0084 15.9 0.2 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 EXF81582.1 - 2e-07 31.4 2.3 0.0008 19.9 0.1 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 EXF81582.1 - 5.1e-07 29.3 6.2 6.5e-07 28.9 0.5 2.9 2 1 1 3 3 3 1 TPR repeat TPR_16 PF13432.6 EXF81582.1 - 8.9e-07 29.5 5.0 0.00024 21.7 0.2 2.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 EXF81582.1 - 8.7e-06 26.1 3.9 0.0049 17.6 0.1 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 EXF81582.1 - 6e-05 23.1 1.9 0.038 14.4 0.1 3.0 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 EXF81582.1 - 0.00012 22.3 6.6 0.058 13.7 3.2 3.1 2 1 0 2 2 2 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EXF81582.1 - 0.0015 18.7 2.0 0.0049 17.1 1.9 1.9 1 1 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 EXF81582.1 - 0.0076 16.4 1.5 2.7 8.4 0.0 3.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.6 EXF81582.1 - 0.008 16.3 0.2 0.035 14.3 0.2 2.1 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_10 PF13374.6 EXF81582.1 - 0.018 14.9 8.2 0.044 13.7 0.1 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat CHIP_TPR_N PF18391.1 EXF81582.1 - 0.019 15.7 12.8 0.048 14.4 12.8 1.7 1 0 0 1 1 1 0 CHIP N-terminal tetratricopeptide repeat domain ImpA_N PF06812.12 EXF81582.1 - 0.027 14.6 0.5 0.027 14.6 0.5 1.9 1 1 1 2 2 2 0 ImpA, N-terminal, type VI secretion system TPR_7 PF13176.6 EXF81582.1 - 0.1 12.6 2.6 2.6 8.3 0.0 3.6 3 1 1 4 4 4 0 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.6 EXF81582.1 - 0.22 11.9 1.9 1.2 9.6 0.0 2.3 1 1 1 2 2 2 0 Alkyl sulfatase dimerisation TPR_6 PF13174.6 EXF81582.1 - 1 10.1 6.4 5.3 7.9 1.0 3.5 4 0 0 4 4 2 0 Tetratricopeptide repeat ToxB_N PF18224.1 EXF81584.1 - 7.8e-25 86.6 0.2 9.6e-25 86.3 0.2 1.1 1 0 0 1 1 1 1 ToxB N-terminal domain DIE2_ALG10 PF04922.12 EXF81586.1 - 4e-121 405.0 3.6 2.4e-83 280.6 0.4 2.1 2 0 0 2 2 2 2 DIE2/ALG10 family GST_C_2 PF13410.6 EXF81586.1 - 0.22 11.6 2.6 3.3 7.8 0.4 2.7 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain QCR10 PF09796.9 EXF81587.1 - 3.9e-26 90.9 0.5 5.2e-26 90.5 0.5 1.2 1 0 0 1 1 1 1 Ubiquinol-cytochrome-c reductase complex subunit (QCR10) UCR_6-4kD PF08997.10 EXF81587.1 - 0.49 10.4 3.1 11 6.0 3.1 2.8 1 1 0 1 1 1 0 Ubiquinol-cytochrome C reductase complex, 6.4kD protein Med4 PF10018.9 EXF81588.1 - 1.7e-35 122.5 0.6 1.7e-35 122.5 0.6 1.9 2 1 0 2 2 2 1 Vitamin-D-receptor interacting Mediator subunit 4 KIAA1430 PF13879.6 EXF81588.1 - 0.0017 19.1 1.9 0.0024 18.6 0.4 2.0 2 0 0 2 2 2 1 KIAA1430 homologue DUF4407 PF14362.6 EXF81588.1 - 0.084 12.2 5.2 1.3 8.3 0.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) DUF4065 PF13274.6 EXF81588.1 - 0.11 13.4 0.2 4.2 8.3 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4065) Cas_Csa5 PF09702.10 EXF81588.1 - 0.12 12.6 1.6 8.6 6.7 0.0 2.3 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_Csa5) DUF4337 PF14235.6 EXF81588.1 - 6.3 6.9 7.1 2.7 8.1 4.5 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4337) EMP70 PF02990.16 EXF81589.1 - 2e-200 666.9 5.7 2.8e-200 666.4 5.7 1.2 1 0 0 1 1 1 1 Endomembrane protein 70 Sas10_Utp3 PF04000.15 EXF81590.1 - 7.5e-17 61.7 0.7 7.5e-17 61.7 0.7 1.8 2 0 0 2 2 2 1 Sas10/Utp3/C1D family FMO-like PF00743.19 EXF81591.1 - 6.1e-18 64.5 0.0 3.1e-17 62.2 0.0 1.9 1 1 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EXF81591.1 - 2.2e-16 60.0 0.2 2e-15 56.9 0.4 2.2 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EXF81591.1 - 1.9e-13 50.4 0.0 2.2e-12 46.8 0.1 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EXF81591.1 - 1.4e-10 40.9 0.0 7.5e-09 35.2 0.0 2.9 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 EXF81591.1 - 1.3e-05 25.3 0.3 5.9e-05 23.2 0.0 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EXF81591.1 - 0.00027 20.6 6.3 0.0035 17.0 4.0 2.8 2 1 1 3 3 3 1 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.21 EXF81591.1 - 0.00032 20.0 0.7 0.056 12.7 0.3 2.2 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox PF00070.27 EXF81591.1 - 0.00036 21.0 3.4 0.084 13.4 0.0 2.6 3 0 0 3 3 2 1 Pyridine nucleotide-disulphide oxidoreductase Shikimate_DH PF01488.20 EXF81591.1 - 0.0042 17.1 0.1 2.5 8.2 0.0 2.5 3 0 0 3 3 3 2 Shikimate / quinate 5-dehydrogenase NAD_binding_9 PF13454.6 EXF81591.1 - 0.0084 16.1 1.7 0.45 10.5 0.1 3.4 4 0 0 4 4 4 1 FAD-NAD(P)-binding 3HCDH_N PF02737.18 EXF81591.1 - 0.0095 15.8 0.5 0.015 15.2 0.5 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain HI0933_like PF03486.14 EXF81591.1 - 0.028 13.2 1.0 0.4 9.3 0.6 2.6 3 0 0 3 3 3 0 HI0933-like protein FAD_oxidored PF12831.7 EXF81591.1 - 0.25 10.6 0.2 0.47 9.7 0.0 1.6 2 0 0 2 2 2 0 FAD dependent oxidoreductase GIDA PF01134.22 EXF81591.1 - 1.6 7.8 3.5 1 8.4 0.8 1.9 2 0 0 2 2 2 0 Glucose inhibited division protein A FAD_binding_2 PF00890.24 EXF81591.1 - 3.5 6.6 9.2 0.059 12.4 2.3 1.5 2 0 0 2 2 2 0 FAD binding domain TPR_12 PF13424.6 EXF81592.1 - 1.5e-13 50.8 19.3 8.5e-05 22.8 2.3 8.2 8 0 0 8 8 8 3 Tetratricopeptide repeat AAA_22 PF13401.6 EXF81592.1 - 3e-06 27.5 0.0 1.4e-05 25.4 0.0 2.1 1 0 0 1 1 1 1 AAA domain TPR_7 PF13176.6 EXF81592.1 - 2.2e-05 24.2 14.1 1.4 9.1 0.0 7.5 7 0 0 7 7 7 2 Tetratricopeptide repeat NACHT PF05729.12 EXF81592.1 - 2.7e-05 24.1 0.0 0.00011 22.2 0.0 2.1 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 EXF81592.1 - 0.0011 19.4 0.0 0.0042 17.5 0.0 2.0 1 0 0 1 1 1 1 AAA ATPase domain TPR_1 PF00515.28 EXF81592.1 - 0.0012 18.6 4.9 13 5.8 0.1 6.2 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_19 PF14559.6 EXF81592.1 - 0.026 15.0 1.7 14 6.2 0.0 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.6 EXF81592.1 - 0.047 14.3 4.3 16 6.4 0.2 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_14 PF13428.6 EXF81592.1 - 0.14 13.1 2.7 2.4e+02 3.0 0.0 5.8 6 0 0 6 6 6 0 Tetratricopeptide repeat Coilin_N PF15862.5 EXF81593.1 - 0.23 11.3 0.5 0.36 10.6 0.5 1.4 1 0 0 1 1 1 0 Coilin N-terminus PhoD PF09423.10 EXF81595.1 - 1.8e-116 389.0 3.8 2.2e-116 388.7 3.8 1.1 1 0 0 1 1 1 1 PhoD-like phosphatase PhoD_N PF16655.5 EXF81595.1 - 2.8e-30 104.7 0.2 2.8e-30 104.7 0.2 2.2 2 0 0 2 2 2 1 PhoD-like phosphatase, N-terminal domain Pur_ac_phosph_N PF16656.5 EXF81595.1 - 0.0071 16.9 1.4 0.02 15.5 0.2 2.5 2 0 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain DUF5012 PF16404.5 EXF81595.1 - 0.013 15.6 1.1 0.032 14.4 0.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF5012) Transp_cyt_pur PF02133.15 EXF81596.1 - 2.1e-154 514.6 33.5 2.4e-154 514.4 33.5 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Romo1 PF10247.9 EXF81597.1 - 0.028 14.8 1.2 0.062 13.7 0.5 1.9 2 0 0 2 2 2 0 Reactive mitochondrial oxygen species modulator 1 DUF3188 PF11384.8 EXF81597.1 - 0.17 11.7 0.4 0.3 10.8 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3188) Gram_pos_anchor PF00746.21 EXF81597.1 - 3.3 7.8 6.8 0.2 11.7 0.4 2.3 2 0 0 2 2 2 0 LPXTG cell wall anchor motif CVNH PF08881.10 EXF81598.1 - 0.014 16.1 0.0 0.043 14.5 0.0 1.8 1 1 0 1 1 1 0 CVNH domain adh_short_C2 PF13561.6 EXF81599.1 - 2.9e-46 157.9 0.0 1.1e-28 100.3 0.0 2.0 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF81599.1 - 1.5e-35 122.4 0.0 1.6e-21 76.7 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase KR PF08659.10 EXF81599.1 - 7.9e-09 35.7 0.0 1.5e-08 34.8 0.0 1.4 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EXF81599.1 - 0.0005 19.6 0.0 0.68 9.3 0.0 2.2 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family PIF6 PF05341.11 EXF81599.1 - 0.027 14.6 0.0 0.055 13.6 0.0 1.5 1 0 0 1 1 1 0 Per os infectivity factor 6 Glyco_tran_WecB PF03808.13 EXF81599.1 - 0.044 13.7 0.0 0.095 12.6 0.0 1.6 2 0 0 2 2 2 0 Glycosyl transferase WecB/TagA/CpsF family GDP_Man_Dehyd PF16363.5 EXF81599.1 - 0.12 11.7 0.0 1.2 8.5 0.0 2.0 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase DUF2703 PF10865.8 EXF81599.1 - 0.15 12.2 0.1 0.46 10.7 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF2703) Transketolase_N PF00456.21 EXF81600.1 - 2.8e-132 440.7 0.1 5.1e-132 439.9 0.1 1.3 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.24 EXF81600.1 - 7.9e-37 126.6 0.0 2.4e-36 125.1 0.0 1.8 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 EXF81600.1 - 3.6e-09 36.6 0.0 9e-09 35.3 0.0 1.7 1 0 0 1 1 1 1 Transketolase, C-terminal domain DXP_synthase_N PF13292.6 EXF81600.1 - 5.5e-07 29.1 0.0 1.4e-06 27.7 0.0 1.6 1 1 1 2 2 2 1 1-deoxy-D-xylulose-5-phosphate synthase E1_dh PF00676.20 EXF81600.1 - 9.4e-07 28.1 0.1 1.8e-06 27.2 0.1 1.4 1 0 0 1 1 1 1 Dehydrogenase E1 component Lant_dehydr_C PF14028.6 EXF81600.1 - 0.096 12.2 0.0 0.2 11.2 0.0 1.4 1 0 0 1 1 1 0 Lantibiotic biosynthesis dehydratase C-term Fungal_trans_2 PF11951.8 EXF81601.1 - 9.1e-17 60.9 3.3 2.1e-16 59.7 3.3 1.5 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF81601.1 - 5.5e-07 29.6 12.1 9.7e-07 28.8 12.1 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Sugar_tr PF00083.24 EXF81602.1 - 1.1e-109 367.4 20.7 1.2e-109 367.2 20.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF81602.1 - 5.6e-29 101.2 56.0 1.1e-23 83.7 24.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 EXF81602.1 - 0.0015 16.9 0.7 0.0036 15.7 0.7 1.6 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family ECH_1 PF00378.20 EXF81603.1 - 1.8e-54 184.7 0.0 2.1e-39 135.4 0.0 2.0 2 0 0 2 2 2 2 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EXF81603.1 - 6.4e-24 85.1 0.1 2e-10 40.7 0.0 3.0 2 1 1 3 3 3 3 Enoyl-CoA hydratase/isomerase GH131_N PF18271.1 EXF81604.1 - 1.7e-81 273.7 0.6 2e-81 273.5 0.6 1.0 1 0 0 1 1 1 1 Glycoside hydrolase 131 catalytic N-terminal domain MFS_1 PF07690.16 EXF81605.1 - 1.3e-17 63.8 22.0 2.3e-17 62.9 22.1 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 EXF81605.1 - 2.2e-07 29.7 5.3 2.6e-07 29.4 5.3 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EXF81605.1 - 0.00012 21.1 5.6 0.00012 21.1 5.6 2.0 2 0 0 2 2 2 1 Sugar (and other) transporter Cation_ATPase_C PF00689.21 EXF81605.1 - 0.0025 17.6 1.0 0.0025 17.6 1.0 1.7 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Glyco_hydro_28 PF00295.17 EXF81607.1 - 1.4e-46 159.1 0.9 1.8e-46 158.7 0.9 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 adh_short PF00106.25 EXF81609.1 - 5.3e-31 107.6 0.0 7.1e-31 107.2 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF81609.1 - 3.7e-20 72.5 0.0 6.8e-20 71.6 0.0 1.4 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF81609.1 - 1.4e-11 44.6 0.0 1.9e-11 44.2 0.0 1.2 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EXF81609.1 - 0.00014 21.1 0.0 0.00017 20.8 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Glyco_tran_WecB PF03808.13 EXF81609.1 - 0.042 13.8 0.0 0.074 13.0 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase WecB/TagA/CpsF family Epimerase PF01370.21 EXF81609.1 - 0.11 11.9 0.0 0.25 10.8 0.0 1.6 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Zn_clus PF00172.18 EXF81610.1 - 1.6e-07 31.3 13.0 1.6e-07 31.3 13.0 1.6 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Coatomer_WDAD PF04053.14 EXF81611.1 - 2.9e-174 580.3 0.0 1e-173 578.5 0.0 1.8 2 0 0 2 2 2 1 Coatomer WD associated region WD40 PF00400.32 EXF81611.1 - 7e-40 134.3 5.8 4.4e-06 27.3 0.0 8.7 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EXF81611.1 - 5.1e-08 33.1 0.1 2.8 8.3 0.0 6.1 4 2 1 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EXF81611.1 - 3.4e-05 22.7 2.0 0.032 12.9 0.0 3.9 2 2 2 4 4 4 3 Nucleoporin Nup120/160 BBS2_Mid PF14783.6 EXF81611.1 - 0.0031 17.5 0.1 1.1 9.4 0.0 3.5 2 2 1 3 3 3 1 Ciliary BBSome complex subunit 2, middle region Mannitol_dh_C PF08125.13 EXF81612.1 - 2.3e-39 135.3 0.0 3.6e-39 134.7 0.0 1.3 1 0 0 1 1 1 1 Mannitol dehydrogenase C-terminal domain Mannitol_dh PF01232.23 EXF81612.1 - 2e-18 67.0 0.0 5.6e-18 65.5 0.0 1.8 1 0 0 1 1 1 1 Mannitol dehydrogenase Rossmann domain UDPG_MGDP_dh_N PF03721.14 EXF81612.1 - 0.0049 16.5 0.4 0.015 14.9 0.1 1.9 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain ApbA PF02558.16 EXF81612.1 - 0.005 16.5 0.2 0.64 9.6 0.0 3.2 3 1 0 3 3 3 1 Ketopantoate reductase PanE/ApbA Sacchrp_dh_NADP PF03435.18 EXF81612.1 - 0.016 15.4 0.4 1.1 9.5 0.1 2.7 3 0 0 3 3 3 0 Saccharopine dehydrogenase NADP binding domain RuBisCO_small PF00101.20 EXF81612.1 - 0.17 11.9 0.0 0.34 10.9 0.0 1.5 1 0 0 1 1 1 0 Ribulose bisphosphate carboxylase, small chain PGI PF00342.19 EXF81613.1 - 1.3e-221 736.4 0.5 1.5e-221 736.2 0.5 1.1 1 0 0 1 1 1 1 Phosphoglucose isomerase Pkinase_C PF00433.24 EXF81614.1 - 2.1e-13 50.7 2.8 6.3e-13 49.2 2.2 2.1 2 0 0 2 2 2 1 Protein kinase C terminal domain C2 PF00168.30 EXF81614.1 - 0.031 14.6 0.0 0.052 13.9 0.0 1.3 1 0 0 1 1 1 0 C2 domain MFS_1 PF07690.16 EXF81615.1 - 5e-36 124.4 40.8 2.4e-32 112.2 40.8 2.1 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 EXF81615.1 - 9e-13 47.5 14.9 3.7e-12 45.5 14.8 1.7 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EXF81615.1 - 4.8e-07 29.0 11.5 4.8e-07 29.0 11.5 2.3 2 0 0 2 2 2 1 Sugar (and other) transporter MFS_3 PF05977.13 EXF81615.1 - 7.3 4.9 15.7 0.42 9.0 7.1 2.4 2 1 0 2 2 2 0 Transmembrane secretion effector GMC_oxred_N PF00732.19 EXF81616.1 - 1.1e-78 264.6 0.0 1.6e-78 264.1 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EXF81616.1 - 4.8e-34 117.9 0.0 1e-33 116.9 0.0 1.6 1 1 0 1 1 1 1 GMC oxidoreductase Lycopene_cycl PF05834.12 EXF81616.1 - 0.00033 19.8 0.1 0.00052 19.2 0.1 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein FAD_binding_2 PF00890.24 EXF81616.1 - 0.00072 18.7 0.0 0.65 9.0 0.0 2.3 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.24 EXF81616.1 - 0.0058 16.2 0.4 0.042 13.4 0.4 2.2 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EXF81616.1 - 0.01 15.1 0.0 0.018 14.3 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EXF81616.1 - 0.018 14.3 0.0 0.033 13.4 0.0 1.4 1 0 0 1 1 1 0 Thi4 family Pyr_redox PF00070.27 EXF81616.1 - 0.074 13.6 0.3 0.36 11.4 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.18 EXF81616.1 - 0.18 12.1 0.0 0.41 10.9 0.0 1.6 1 0 0 1 1 1 0 TrkA-N domain FMN_dh PF01070.18 EXF81617.1 - 7e-107 357.5 0.0 8.3e-107 357.2 0.0 1.1 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Glu_synthase PF01645.17 EXF81617.1 - 0.00022 20.5 0.2 0.00032 20.0 0.2 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.25 EXF81617.1 - 0.00024 20.2 0.2 0.00039 19.5 0.2 1.2 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain His_biosynth PF00977.21 EXF81617.1 - 0.013 15.0 0.4 0.069 12.6 0.3 2.0 1 1 1 2 2 2 0 Histidine biosynthesis protein AMP-binding PF00501.28 EXF81618.1 - 4.5e-150 499.9 0.0 1.7e-76 257.6 0.0 2.2 2 0 0 2 2 2 2 AMP-binding enzyme Condensation PF00668.20 EXF81618.1 - 1.4e-40 139.4 0.0 4.6e-36 124.5 0.0 2.4 2 1 0 2 2 2 2 Condensation domain NAD_binding_4 PF07993.12 EXF81618.1 - 2.7e-37 128.4 0.0 4.8e-37 127.5 0.0 1.4 1 0 0 1 1 1 1 Male sterility protein PP-binding PF00550.25 EXF81618.1 - 1.7e-19 69.9 0.1 7.6e-13 48.6 0.0 2.8 2 0 0 2 2 2 2 Phosphopantetheine attachment site Epimerase PF01370.21 EXF81618.1 - 1.4e-06 28.0 0.0 3.2e-06 26.8 0.0 1.6 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family AMP-binding_C PF13193.6 EXF81618.1 - 2.5e-05 25.2 0.0 0.027 15.5 0.0 2.9 2 0 0 2 2 2 2 AMP-binding enzyme C-terminal domain GDP_Man_Dehyd PF16363.5 EXF81618.1 - 0.017 14.5 0.0 0.071 12.5 0.0 2.0 1 1 0 1 1 1 0 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 EXF81618.1 - 0.33 10.8 1.6 9.4 6.1 0.3 3.0 3 0 0 3 3 3 0 NAD(P)H-binding MFS_1 PF07690.16 EXF81619.1 - 4.4e-38 131.1 45.6 9.8e-38 130.0 45.6 1.7 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF81619.1 - 7.9e-08 31.6 11.0 7.9e-08 31.6 11.0 2.8 2 1 0 3 3 3 2 Sugar (and other) transporter Meth_synt_2 PF01717.18 EXF81620.1 - 1.4e-09 37.7 0.0 8.1e-07 28.6 0.0 2.9 2 1 0 2 2 2 2 Cobalamin-independent synthase, Catalytic domain Rhodanese PF00581.20 EXF81621.1 - 2.9e-12 47.0 0.0 4e-12 46.6 0.0 1.2 1 0 0 1 1 1 1 Rhodanese-like domain Pectate_lyase PF03211.13 EXF81622.1 - 4.2e-77 258.3 7.6 5.1e-77 258.0 7.6 1.0 1 0 0 1 1 1 1 Pectate lyase Acyl-CoA_dh_1 PF00441.24 EXF81623.1 - 3.1e-22 79.4 0.0 5.4e-22 78.6 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 EXF81623.1 - 5.8e-15 55.9 0.0 1.2e-14 54.9 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 EXF81623.1 - 0.0012 19.2 0.1 0.0027 18.0 0.0 1.6 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 EXF81623.1 - 0.0018 18.4 0.0 0.0045 17.2 0.0 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain MFS_1 PF07690.16 EXF81625.1 - 2.3e-24 86.0 63.3 1.7e-23 83.2 39.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DIT1_PvcA PF05141.12 EXF81626.1 - 3.5e-87 292.4 0.0 5.7e-87 291.7 0.0 1.3 1 0 0 1 1 1 1 Pyoverdine/dityrosine biosynthesis protein DHO_dh PF01180.21 EXF81627.1 - 5.1e-69 232.7 0.5 1.2e-57 195.4 0.0 2.1 2 0 0 2 2 2 2 Dihydroorotate dehydrogenase Mpv17_PMP22 PF04117.12 EXF81627.1 - 5.4e-15 55.4 0.2 1.1e-14 54.4 0.2 1.6 1 0 0 1 1 1 1 Mpv17 / PMP22 family PcrB PF01884.17 EXF81627.1 - 0.01 15.3 0.6 0.44 10.0 0.1 2.3 2 0 0 2 2 2 0 PcrB family FMN_dh PF01070.18 EXF81627.1 - 0.017 14.2 0.4 0.32 10.0 0.3 2.2 2 0 0 2 2 2 0 FMN-dependent dehydrogenase HET PF06985.11 EXF81628.1 - 8.7e-12 45.6 3.6 1.8e-08 34.9 0.6 2.4 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) Nuf2 PF03800.14 EXF81632.1 - 2.9e-42 144.1 0.0 7.5e-42 142.7 0.0 1.8 1 0 0 1 1 1 1 Nuf2 family DHR10 PF18595.1 EXF81632.1 - 9.9e-37 125.6 17.2 9.9e-37 125.6 17.2 4.0 3 1 0 3 3 3 1 Designed helical repeat protein 10 domain Troponin PF00992.20 EXF81632.1 - 1.5 9.1 44.8 1.2 9.5 16.0 3.3 2 2 1 3 3 3 0 Troponin DUF3287 PF11690.8 EXF81632.1 - 6.1 6.6 19.5 0.18 11.5 4.5 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF3287) Adaptin_N PF01602.20 EXF81634.1 - 8.5e-106 354.6 0.0 1e-105 354.3 0.0 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EXF81634.1 - 2.1e-14 53.9 0.1 1.8e-13 50.8 0.0 2.6 3 1 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EXF81634.1 - 4.6e-11 43.0 4.0 7.7e-05 23.0 0.0 5.5 4 2 3 7 7 6 3 HEAT repeats HEAT PF02985.22 EXF81634.1 - 1.4e-09 37.3 0.6 0.03 14.6 0.0 5.9 6 0 0 6 6 6 2 HEAT repeat HEAT_EZ PF13513.6 EXF81634.1 - 0.00016 22.1 4.4 0.027 15.0 0.0 4.7 4 0 0 4 4 4 1 HEAT-like repeat Cohesin_HEAT PF12765.7 EXF81634.1 - 0.00024 21.3 1.1 0.053 13.8 0.0 3.2 3 0 0 3 3 3 1 HEAT repeat associated with sister chromatid cohesion CDC45 PF02724.14 EXF81634.1 - 0.11 10.7 20.9 0.2 9.9 20.9 1.3 1 0 0 1 1 1 0 CDC45-like protein PPP4R2 PF09184.11 EXF81634.1 - 0.4 10.2 21.3 0.67 9.5 21.3 1.3 1 0 0 1 1 1 0 PPP4R2 RNA_pol_3_Rpc31 PF11705.8 EXF81634.1 - 0.42 10.8 26.5 0.7 10.1 26.5 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Cwf_Cwc_15 PF04889.12 EXF81634.1 - 0.47 10.2 20.8 0.67 9.6 20.8 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein SDA1 PF05285.12 EXF81634.1 - 0.83 9.0 27.0 1.2 8.5 27.0 1.2 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 EXF81634.1 - 3.6 5.7 30.5 4.8 5.3 30.5 1.1 1 0 0 1 1 1 0 Nop14-like family BUD22 PF09073.10 EXF81634.1 - 3.8 6.8 21.7 5.4 6.3 21.7 1.2 1 0 0 1 1 1 0 BUD22 RTA1 PF04479.13 EXF81635.1 - 1.3e-71 240.5 4.8 1.8e-71 240.0 4.8 1.2 1 0 0 1 1 1 1 RTA1 like protein PGG PF13962.6 EXF81635.1 - 0.034 14.0 0.2 0.088 12.6 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function NAD_binding_2 PF03446.15 EXF81637.1 - 1e-36 126.5 0.0 1.6e-36 125.9 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 EXF81637.1 - 4e-29 101.3 0.0 6.5e-29 100.7 0.0 1.4 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase F420_oxidored PF03807.17 EXF81637.1 - 1.2e-06 29.0 0.2 3.4e-06 27.5 0.0 1.9 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent OCD_Mu_crystall PF02423.15 EXF81637.1 - 5.7e-05 22.2 0.0 0.0001 21.4 0.0 1.3 1 0 0 1 1 1 1 Ornithine cyclodeaminase/mu-crystallin family TrkA_N PF02254.18 EXF81637.1 - 0.00033 20.9 0.0 0.00058 20.1 0.0 1.4 1 0 0 1 1 1 1 TrkA-N domain Ldh_1_N PF00056.23 EXF81637.1 - 0.014 15.5 0.1 0.03 14.4 0.1 1.5 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 EXF81637.1 - 0.02 15.0 0.0 0.034 14.2 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase 3HCDH_N PF02737.18 EXF81637.1 - 0.056 13.3 0.1 0.17 11.7 0.1 1.9 1 1 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GFO_IDH_MocA PF01408.22 EXF81637.1 - 0.093 13.6 0.0 0.19 12.5 0.0 1.5 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold KilA-N PF04383.13 EXF81638.1 - 0.035 13.9 0.0 0.25 11.2 0.0 2.2 1 1 0 1 1 1 0 KilA-N domain NUP50 PF08911.11 EXF81638.1 - 0.8 10.4 6.9 16 6.3 2.4 3.0 2 0 0 2 2 2 0 NUP50 (Nucleoporin 50 kDa) Rho_GDI PF02115.17 EXF81639.1 - 1.1e-60 204.7 1.8 1.5e-60 204.3 0.2 1.8 2 0 0 2 2 2 1 RHO protein GDP dissociation inhibitor Metallophos PF00149.28 EXF81640.1 - 2.4e-35 122.9 0.1 3.6e-35 122.3 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EXF81640.1 - 0.063 13.5 0.0 0.1 12.8 0.0 1.3 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain STPPase_N PF16891.5 EXF81640.1 - 0.078 13.4 0.4 0.21 12.1 0.4 1.7 1 1 0 1 1 1 0 Serine-threonine protein phosphatase N-terminal domain zf-CCHC PF00098.23 EXF81641.1 - 0.00095 19.1 0.6 0.0018 18.3 0.6 1.5 1 0 0 1 1 1 1 Zinc knuckle Nucleocapsid-N PF11030.8 EXF81641.1 - 0.26 11.2 6.8 0.76 9.7 6.8 1.7 1 0 0 1 1 1 0 Nucleocapsid protein N Egh16-like PF11327.8 EXF81642.1 - 1e-67 228.1 12.2 1.3e-67 227.8 12.2 1.1 1 0 0 1 1 1 1 Egh16-like virulence factor TTL PF03133.15 EXF81643.1 - 1.9e-32 112.6 0.0 6.3e-32 110.9 0.0 1.7 1 1 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 EXF81643.1 - 0.00088 18.6 0.0 0.0024 17.2 0.0 1.7 1 0 0 1 1 1 1 YheC/D like ATP-grasp Dala_Dala_lig_C PF07478.13 EXF81643.1 - 0.012 15.2 0.0 0.023 14.2 0.0 1.4 1 0 0 1 1 1 0 D-ala D-ala ligase C-terminus HAUS6_N PF14661.6 EXF81644.1 - 4.3e-56 190.1 3.4 8.1e-56 189.2 3.4 1.5 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 6 N-terminus Ribosomal_S21 PF01165.20 EXF81645.1 - 3.3e-14 52.3 3.9 4.9e-14 51.8 3.9 1.3 1 0 0 1 1 1 1 Ribosomal protein S21 PWI PF01480.17 EXF81646.1 - 4e-15 55.9 0.6 9.7e-15 54.6 0.6 1.7 1 0 0 1 1 1 1 PWI domain RRM_1 PF00076.22 EXF81646.1 - 0.036 13.9 0.0 0.086 12.7 0.0 1.7 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) EBV-NA1 PF02905.14 EXF81646.1 - 1.7 8.5 3.5 44 3.9 0.0 2.4 2 0 0 2 2 2 0 Epstein Barr virus nuclear antigen-1, DNA-binding domain Nuc_sug_transp PF04142.15 EXF81647.1 - 3.9e-49 167.5 1.9 5.1e-49 167.1 1.9 1.0 1 0 0 1 1 1 1 Nucleotide-sugar transporter UAA PF08449.11 EXF81647.1 - 1.6e-05 24.3 0.8 1.6e-05 24.3 0.8 1.9 3 0 0 3 3 3 1 UAA transporter family CRT-like PF08627.10 EXF81647.1 - 0.00045 19.3 0.4 0.00075 18.5 0.4 1.3 1 0 0 1 1 1 1 CRT-like, chloroquine-resistance transporter-like PUNUT PF16913.5 EXF81647.1 - 0.00076 18.8 2.1 0.0016 17.8 0.9 1.9 1 1 1 2 2 2 1 Purine nucleobase transmembrane transport EamA PF00892.20 EXF81647.1 - 0.0056 16.8 1.7 0.0056 16.8 1.7 3.1 3 2 0 3 3 3 1 EamA-like transporter family Phage_holin_5_1 PF06946.11 EXF81647.1 - 0.014 15.7 0.2 0.036 14.4 0.2 1.7 1 0 0 1 1 1 0 Bacteriophage A118-like holin, Hol118 MerC PF03203.14 EXF81647.1 - 0.8 10.2 10.5 12 6.4 10.5 2.7 1 1 0 1 1 1 0 MerC mercury resistance protein MFS_1 PF07690.16 EXF81650.1 - 1.5e-42 145.8 40.2 1.5e-42 145.8 40.2 2.5 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF81650.1 - 3.4e-11 42.7 36.2 9.8e-07 28.0 6.3 3.7 3 1 0 4 4 4 3 Sugar (and other) transporter Phage_holin_3_2 PF04550.12 EXF81650.1 - 0.11 13.1 2.2 0.55 10.8 2.2 2.2 1 0 0 1 1 1 0 Phage holin family 2 HD_3 PF13023.6 EXF81653.1 - 2.2e-49 167.5 0.0 3.3e-49 167.0 0.0 1.3 1 0 0 1 1 1 1 HD domain GFO_IDH_MocA PF01408.22 EXF81653.1 - 8.2e-22 78.3 0.3 1.4e-21 77.5 0.3 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 EXF81653.1 - 1e-13 51.3 0.1 2.7e-13 49.9 0.0 1.7 2 0 0 2 2 2 1 Oxidoreductase family, C-terminal alpha/beta domain HD_2 PF12917.7 EXF81653.1 - 2.5e-08 33.9 0.0 4.1e-08 33.2 0.0 1.3 1 0 0 1 1 1 1 HD containing hydrolase-like enzyme Glyco_hydro_43 PF04616.14 EXF81654.1 - 6.9e-22 78.1 12.9 1.5e-10 40.9 0.3 3.5 3 1 0 3 3 3 3 Glycosyl hydrolases family 43 AltA1 PF16541.5 EXF81655.1 - 9.8e-07 29.6 0.0 1.3e-06 29.2 0.0 1.1 1 0 0 1 1 1 1 Alternaria alternata allergen 1 DIOX_N PF14226.6 EXF81656.1 - 3e-21 76.4 0.0 5.2e-21 75.6 0.0 1.4 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EXF81656.1 - 5e-13 49.4 0.0 8.6e-13 48.6 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily CvfB_WH PF17783.1 EXF81656.1 - 0.068 13.0 0.0 0.14 11.9 0.0 1.5 1 0 0 1 1 1 0 CvfB-like winged helix domain Fungal_trans_2 PF11951.8 EXF81657.1 - 2.6e-38 131.9 3.0 4.2e-38 131.1 3.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Lyase_1 PF00206.20 EXF81657.1 - 0.071 12.5 0.1 0.13 11.7 0.1 1.3 1 0 0 1 1 1 0 Lyase Sugar_tr PF00083.24 EXF81658.1 - 2.2e-77 260.9 27.5 2.5e-77 260.7 27.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF81658.1 - 2.2e-17 63.0 39.0 2.7e-15 56.2 36.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 EXF81658.1 - 0.0021 17.0 3.7 0.0021 17.0 3.7 2.2 2 1 0 2 2 2 1 MFS_1 like family YtpI PF14007.6 EXF81658.1 - 1.5 9.1 12.4 2.7 8.2 4.3 3.0 3 0 0 3 3 3 0 YtpI-like protein Transferase PF02458.15 EXF81660.1 - 3.4e-19 68.8 0.0 4e-17 62.0 0.0 2.0 2 0 0 2 2 2 2 Transferase family Fructosamin_kin PF03881.14 EXF81661.1 - 3.8e-27 95.2 0.0 4.9e-27 94.9 0.0 1.0 1 0 0 1 1 1 1 Fructosamine kinase APH PF01636.23 EXF81661.1 - 0.00027 21.0 0.1 0.00032 20.7 0.1 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family p450 PF00067.22 EXF81664.1 - 1.7e-40 139.1 0.0 2.3e-40 138.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 ORF6C PF10552.9 EXF81664.1 - 0.071 13.2 0.0 0.12 12.4 0.0 1.3 1 0 0 1 1 1 0 ORF6C domain Methyltransf_23 PF13489.6 EXF81665.1 - 0.00047 20.0 0.0 0.00062 19.6 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF81665.1 - 0.0078 16.8 0.0 0.015 15.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF81665.1 - 0.04 14.7 0.0 0.077 13.7 0.0 1.5 2 0 0 2 2 2 0 Methyltransferase domain His_Phos_1 PF00300.22 EXF81666.1 - 4.8e-37 127.5 1.0 6.2e-35 120.7 1.0 2.4 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) UCH PF00443.29 EXF81669.1 - 6.4e-50 170.0 0.0 8.9e-50 169.6 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EXF81669.1 - 1.9e-12 47.4 7.7 8.9e-11 41.9 7.7 2.4 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.23 EXF81669.1 - 3.7e-12 45.8 0.2 8.5e-11 41.5 0.0 2.4 2 0 0 2 2 2 1 Ubiquitin family Ubiquitin_2 PF14560.6 EXF81669.1 - 0.017 15.6 0.1 0.19 12.2 0.0 2.4 2 0 0 2 2 2 0 Ubiquitin-like domain EPO_TPO PF00758.18 EXF81669.1 - 0.034 14.2 0.1 10 6.1 0.0 2.3 2 0 0 2 2 2 0 Erythropoietin/thrombopoietin Chalcone_2 PF16035.5 EXF81669.1 - 0.097 12.4 0.3 0.27 11.0 0.3 1.8 1 1 0 1 1 1 0 Chalcone isomerase like TBK1_ULD PF18396.1 EXF81669.1 - 0.18 11.8 0.0 0.38 10.7 0.0 1.5 1 0 0 1 1 1 0 TANK binding kinase 1 ubiquitin-like domain ARPC4 PF05856.12 EXF81670.1 - 2e-72 242.2 5.5 2e-72 242.2 5.5 1.5 2 0 0 2 2 2 1 ARP2/3 complex 20 kDa subunit (ARPC4) RRM_1 PF00076.22 EXF81671.1 - 0.076 12.8 0.0 0.22 11.4 0.0 1.8 1 1 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CRAL_TRIO PF00650.20 EXF81672.1 - 3.6e-11 43.0 0.0 5.1e-11 42.5 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EXF81672.1 - 3.9e-06 26.9 0.0 7.9e-06 26.0 0.0 1.5 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain SET PF00856.28 EXF81673.1 - 3.9e-16 59.9 3.1 8.8e-16 58.7 0.6 2.8 2 1 0 2 2 2 1 SET domain AWS PF17907.1 EXF81673.1 - 4.2e-06 26.7 7.6 4.2e-06 26.7 7.6 2.3 2 0 0 2 2 2 1 AWS domain DHHC PF01529.20 EXF81676.1 - 7.6e-26 90.8 1.1 7.6e-26 90.8 1.1 2.1 2 0 0 2 2 2 1 DHHC palmitoyltransferase IMS PF00817.20 EXF81677.1 - 2.8e-40 137.7 0.0 6.5e-40 136.6 0.0 1.6 2 0 0 2 2 2 1 impB/mucB/samB family IMS_C PF11799.8 EXF81677.1 - 2.3e-14 54.1 0.0 5e-14 53.0 0.0 1.5 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain zf_UBZ PF18439.1 EXF81677.1 - 8.5e-13 47.7 2.1 1.8e-12 46.6 2.1 1.6 1 0 0 1 1 1 1 Ubiquitin-Binding Zinc Finger IMS_HHH PF11798.8 EXF81677.1 - 0.055 13.8 0.0 0.15 12.5 0.0 1.7 1 0 0 1 1 1 0 IMS family HHH motif RAP1 PF07218.11 EXF81677.1 - 0.35 9.1 0.1 0.58 8.4 0.1 1.3 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) IBN_N PF03810.19 EXF81679.1 - 2.8e-15 56.0 2.5 3.1e-13 49.4 0.0 3.8 3 0 0 3 3 3 1 Importin-beta N-terminal domain Cse1 PF08506.10 EXF81679.1 - 5.8e-09 35.2 0.3 4.9e-08 32.2 0.0 2.5 2 1 1 3 3 3 1 Cse1 Xpo1 PF08389.12 EXF81679.1 - 6.6e-06 26.2 2.5 0.00011 22.3 0.2 3.8 4 0 0 4 4 4 1 Exportin 1-like protein HEAT_2 PF13646.6 EXF81679.1 - 0.003 17.9 2.8 0.029 14.8 0.1 3.5 4 0 0 4 4 4 1 HEAT repeats GRIP PF01465.20 EXF81679.1 - 0.011 15.6 0.0 0.052 13.5 0.0 2.3 1 0 0 1 1 1 0 GRIP domain UNC45-central PF11701.8 EXF81679.1 - 0.077 13.0 0.1 15 5.6 0.1 3.2 2 1 0 2 2 2 0 Myosin-binding striated muscle assembly central SRA1 PF07304.11 EXF81681.1 - 0.017 14.9 0.3 0.017 14.9 0.3 3.3 4 1 1 5 5 5 0 Steroid receptor RNA activator (SRA1) Fzo_mitofusin PF04799.13 EXF81681.1 - 2.3 7.7 5.2 4.6 6.8 1.2 2.6 2 1 1 3 3 3 0 fzo-like conserved region TT_ORF2 PF02957.15 EXF81682.1 - 1.1 10.2 0.0 1.1 10.2 0.0 3.7 4 0 0 4 4 4 0 TT viral ORF2 ATP-sulfurylase PF01747.17 EXF81683.1 - 2.7e-88 295.0 0.2 4e-88 294.4 0.2 1.2 1 0 0 1 1 1 1 ATP-sulfurylase APS_kinase PF01583.20 EXF81683.1 - 1.8e-57 193.6 0.0 2.9e-57 193.0 0.0 1.3 1 0 0 1 1 1 1 Adenylylsulphate kinase PUA_2 PF14306.6 EXF81683.1 - 4.7e-54 182.4 0.0 7.6e-54 181.7 0.0 1.3 1 0 0 1 1 1 1 PUA-like domain TRP PF06011.12 EXF81684.1 - 7.9e-107 357.6 19.7 1.2e-106 357.0 19.7 1.2 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.6 EXF81684.1 - 9e-38 129.8 0.1 1.4e-37 129.2 0.1 1.3 1 0 0 1 1 1 1 ML-like domain PsbH PF00737.20 EXF81684.1 - 1.5 8.6 6.3 5.6 6.8 0.0 3.6 3 0 0 3 3 3 0 Photosystem II 10 kDa phosphoprotein FAM178 PF14816.6 EXF81687.1 - 0.14 11.1 0.0 0.19 10.7 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function, FAM178 SNARE PF05739.19 EXF81688.1 - 3.9e-13 49.2 0.1 3.9e-13 49.2 0.1 1.8 2 0 0 2 2 2 1 SNARE domain Syntaxin-5_N PF11416.8 EXF81688.1 - 2.1e-09 36.3 0.3 5.9e-09 34.9 0.3 1.8 1 0 0 1 1 1 1 Syntaxin-5 N-terminal, Sly1p-binding domain Syntaxin PF00804.25 EXF81688.1 - 0.00039 20.2 4.9 0.0018 18.0 0.1 2.8 2 1 1 3 3 3 1 Syntaxin Prominin PF05478.11 EXF81688.1 - 0.0061 14.6 0.9 0.58 8.1 0.0 2.2 2 0 0 2 2 2 2 Prominin KxDL PF10241.9 EXF81688.1 - 0.0064 16.7 4.2 1.5 9.2 0.1 3.6 4 0 0 4 4 4 2 Uncharacterized conserved protein Syntaxin-18_N PF10496.9 EXF81688.1 - 0.034 14.4 2.2 0.2 11.9 0.1 2.4 2 0 0 2 2 2 0 SNARE-complex protein Syntaxin-18 N-terminus DUF16 PF01519.16 EXF81688.1 - 0.3 11.6 3.8 1.3 9.5 0.1 2.5 2 1 0 2 2 2 0 Protein of unknown function DUF16 SlyX PF04102.12 EXF81688.1 - 0.34 11.5 0.2 0.34 11.5 0.2 3.4 3 1 1 4 4 4 0 SlyX SF-assemblin PF06705.11 EXF81688.1 - 0.43 9.9 7.2 0.17 11.2 0.6 2.4 3 0 0 3 3 3 0 SF-assemblin/beta giardin NPV_P10 PF05531.12 EXF81688.1 - 0.94 10.0 4.8 14 6.2 0.1 3.4 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein Muted PF14942.6 EXF81688.1 - 1.9 8.8 5.1 2.9 8.2 1.1 2.6 2 1 0 2 2 2 0 Organelle biogenesis, Muted-like protein Aldo_ket_red PF00248.21 EXF81689.1 - 2.7e-47 161.4 0.1 3.6e-45 154.4 0.1 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family YflT PF11181.8 EXF81689.1 - 0.051 14.1 0.1 0.33 11.5 0.0 2.3 3 0 0 3 3 3 0 Heat induced stress protein YflT DUF1833 PF08875.11 EXF81689.1 - 0.12 11.9 0.0 0.2 11.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1833) ADH_N PF08240.12 EXF81690.1 - 2.1e-26 91.9 0.7 2.1e-26 91.9 0.7 1.8 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EXF81690.1 - 2e-14 53.7 0.6 4.1e-14 52.7 0.6 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EXF81690.1 - 2.3e-06 27.2 0.0 0.033 13.7 0.0 2.5 2 1 0 2 2 2 2 Glucose dehydrogenase C-terminus AlaDh_PNT_C PF01262.21 EXF81690.1 - 0.0027 17.0 1.3 0.0027 17.0 1.3 1.8 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain UDPG_MGDP_dh_N PF03721.14 EXF81690.1 - 0.012 15.2 0.3 0.034 13.7 0.1 1.8 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain HI0933_like PF03486.14 EXF81690.1 - 0.013 14.3 0.3 0.021 13.6 0.3 1.3 1 0 0 1 1 1 0 HI0933-like protein ADH_N_2 PF16884.5 EXF81690.1 - 0.24 11.3 0.6 1.6 8.7 0.1 2.4 2 1 0 2 2 2 0 N-terminal domain of oxidoreductase adh_short PF00106.25 EXF81691.1 - 2.7e-50 170.6 0.4 3.4e-50 170.2 0.4 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF81691.1 - 1.4e-47 162.2 0.1 2.5e-47 161.4 0.1 1.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF81691.1 - 4.8e-13 49.4 0.4 1.1e-12 48.3 0.4 1.7 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 EXF81691.1 - 2.8e-06 27.0 0.4 2.1e-05 24.1 0.4 2.1 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Lambda_tail_I PF06805.12 EXF81691.1 - 0.0049 17.2 0.0 0.84 10.0 0.0 2.5 2 0 0 2 2 2 1 Bacteriophage lambda tail assembly protein I GDP_Man_Dehyd PF16363.5 EXF81691.1 - 0.0063 16.0 0.2 0.012 15.0 0.0 1.5 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase NmrA PF05368.13 EXF81691.1 - 0.0095 15.5 3.7 0.11 12.0 1.2 3.0 3 1 0 3 3 3 1 NmrA-like family DUF1815 PF08844.10 EXF81691.1 - 0.012 15.6 0.0 0.022 14.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1815) RmlD_sub_bind PF04321.17 EXF81691.1 - 0.012 14.7 0.2 0.03 13.4 0.1 1.7 2 0 0 2 2 2 0 RmlD substrate binding domain ApbA PF02558.16 EXF81691.1 - 0.044 13.4 0.1 0.086 12.5 0.1 1.5 1 1 0 1 1 1 0 Ketopantoate reductase PanE/ApbA NAD_binding_7 PF13241.6 EXF81691.1 - 0.053 14.0 0.1 0.13 12.7 0.1 1.6 1 0 0 1 1 1 0 Putative NAD(P)-binding Glyco_transf_28 PF03033.20 EXF81691.1 - 0.11 12.5 0.2 21 5.2 0.3 2.6 2 1 0 2 2 2 0 Glycosyltransferase family 28 N-terminal domain DUF1100 PF06500.11 EXF81692.1 - 1.7e-12 46.8 0.0 2.2e-12 46.5 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1100) Peptidase_S9 PF00326.21 EXF81692.1 - 4.2e-06 26.4 0.0 7.8e-06 25.5 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S15 PF02129.18 EXF81692.1 - 1.2e-05 25.0 0.1 2.2e-05 24.2 0.1 1.4 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Esterase PF00756.20 EXF81692.1 - 0.00013 21.7 0.0 0.0013 18.4 0.0 2.2 1 1 0 1 1 1 1 Putative esterase Esterase_phd PF10503.9 EXF81692.1 - 0.00096 18.7 0.1 0.0037 16.8 0.0 1.9 3 0 0 3 3 3 1 Esterase PHB depolymerase Abhydrolase_6 PF12697.7 EXF81692.1 - 0.013 16.1 3.3 0.017 15.7 1.9 1.6 1 1 1 2 2 2 0 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EXF81692.1 - 0.03 13.6 0.0 0.34 10.2 0.0 2.1 1 1 0 2 2 2 0 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.13 EXF81692.1 - 0.11 12.3 0.0 0.21 11.4 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold Acetyltransf_1 PF00583.25 EXF81693.1 - 2.5e-11 43.8 0.1 3.3e-11 43.4 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EXF81693.1 - 7.8e-08 32.6 0.2 1.3e-07 31.9 0.2 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EXF81693.1 - 2e-06 27.8 0.1 2.7e-06 27.3 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain AstA PF04958.12 EXF81693.1 - 0.012 14.2 0.0 0.018 13.6 0.0 1.2 1 0 0 1 1 1 0 Arginine N-succinyltransferase beta subunit Lipase_3 PF01764.25 EXF81694.1 - 2.3e-13 50.2 0.0 4.2e-12 46.1 0.0 2.3 1 1 0 1 1 1 1 Lipase (class 3) DPBB_1 PF03330.18 EXF81695.1 - 1.5e-08 34.8 0.6 6.1e-08 32.8 0.2 2.4 2 1 0 2 2 2 1 Lytic transglycolase Barwin PF00967.17 EXF81695.1 - 2.6e-06 27.3 0.1 5.3e-06 26.3 0.1 1.5 1 0 0 1 1 1 1 Barwin family Pollen_allerg_1 PF01357.21 EXF81695.1 - 0.0006 19.8 0.9 0.0011 18.9 0.4 1.7 2 0 0 2 2 2 1 Pollen allergen BNR PF02012.20 EXF81695.1 - 0.059 13.4 0.2 0.19 11.8 0.2 1.9 1 0 0 1 1 1 0 BNR/Asp-box repeat Mo-co_dimer PF03404.16 EXF81695.1 - 0.063 13.3 0.3 1.4 9.0 0.0 2.3 1 1 1 2 2 2 0 Mo-co oxidoreductase dimerisation domain DUF2367 PF10164.9 EXF81695.1 - 5.8 7.5 6.5 1.5 9.4 0.3 2.5 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2367) C2 PF00168.30 EXF81696.1 - 3.7e-82 271.3 0.1 1.5e-23 83.1 0.0 5.5 5 0 0 5 5 5 5 C2 domain SMP_LBD PF17047.5 EXF81696.1 - 6.5e-06 25.7 0.0 1.2e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 Synaptotagmin-like mitochondrial-lipid-binding domain FKBP_C PF00254.28 EXF81696.1 - 0.044 14.1 0.0 0.17 12.2 0.0 2.1 1 0 0 1 1 1 0 FKBP-type peptidyl-prolyl cis-trans isomerase MLVIN_C PF18697.1 EXF81696.1 - 0.066 13.3 0.2 1.6 8.9 0.1 2.5 2 0 0 2 2 2 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain WD40 PF00400.32 EXF81697.1 - 2.2e-35 120.1 20.1 1.4e-08 35.3 2.1 7.9 7 1 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EXF81697.1 - 1.7e-15 57.0 1.1 0.052 13.8 0.0 6.2 4 2 3 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain PRP4 PF08799.11 EXF81697.1 - 3.4e-13 48.9 3.8 6.2e-13 48.0 3.8 1.5 1 0 0 1 1 1 1 pre-mRNA processing factor 4 (PRP4) like Nbas_N PF15492.6 EXF81697.1 - 0.0096 15.3 0.0 0.82 8.9 0.0 2.2 2 0 0 2 2 2 2 Neuroblastoma-amplified sequence, N terminal Ge1_WD40 PF16529.5 EXF81697.1 - 0.028 13.4 0.0 14 4.5 0.0 4.0 1 1 3 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 EXF81697.1 - 0.048 13.0 0.0 7 5.9 0.0 2.6 2 0 0 2 2 2 0 WD40-like domain Beta_elim_lyase PF01212.21 EXF81698.1 - 8e-60 202.6 0.1 9.3e-60 202.4 0.1 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 EXF81698.1 - 0.00021 20.7 1.3 0.00031 20.2 0.3 1.6 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family MFS_1 PF07690.16 EXF81699.1 - 1.4e-27 96.6 16.1 2e-27 96.1 16.1 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF81699.1 - 5.8e-14 51.8 10.3 1.3e-13 50.6 10.4 1.4 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_4 PF06779.14 EXF81699.1 - 1.2e-06 28.1 5.9 2.1e-06 27.3 5.9 1.4 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB Saf_2TM PF18303.1 EXF81699.1 - 0.051 13.2 0.2 0.19 11.3 0.0 2.0 2 0 0 2 2 2 0 SAVED-fused 2TM effector domain DUF3382 PF11862.8 EXF81699.1 - 0.38 11.1 6.3 3.1 8.1 0.3 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF3382) CDH-cyt PF16010.5 EXF81701.1 - 2.5e-24 86.0 9.3 2.5e-24 86.0 9.3 1.9 2 0 0 2 2 2 1 Cytochrome domain of cellobiose dehydrogenase DOMON PF03351.17 EXF81701.1 - 2e-07 31.3 0.3 4.1e-07 30.2 0.2 1.6 1 1 0 1 1 1 1 DOMON domain DUF2427 PF10348.9 EXF81701.1 - 0.0015 18.3 8.2 0.0015 18.3 8.2 2.5 1 1 1 2 2 2 1 Domain of unknown function (DUF2427) ATP_sub_h PF10775.9 EXF81702.1 - 1.9e-26 91.8 1.1 2.1e-26 91.7 0.4 1.4 2 0 0 2 2 2 1 ATP synthase complex subunit h ATP-synt_F6 PF05511.11 EXF81702.1 - 0.098 13.1 0.0 0.12 12.8 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial ATP synthase coupling factor 6 C2 PF00168.30 EXF81703.1 - 3.8e-09 36.8 0.0 4.7e-06 26.8 0.0 2.4 2 0 0 2 2 2 2 C2 domain SUZ PF12752.7 EXF81707.1 - 2.8e-05 24.8 5.0 2.8e-05 24.8 5.0 3.1 2 2 0 2 2 2 1 SUZ domain DUF1754 PF08555.10 EXF81707.1 - 0.042 14.6 2.8 4.7 8.1 0.9 2.4 2 0 0 2 2 2 0 Eukaryotic family of unknown function (DUF1754) U1snRNP70_N PF12220.8 EXF81707.1 - 0.19 12.4 4.9 0.1 13.2 1.2 2.1 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal Sua5_yciO_yrdC PF01300.18 EXF81707.1 - 0.21 11.1 0.1 0.31 10.5 0.1 1.2 1 0 0 1 1 1 0 Telomere recombination Fe_hyd_lg_C PF02906.14 EXF81708.1 - 1.4e-48 165.7 0.0 5.1e-48 163.9 0.0 1.8 1 1 0 1 1 1 1 Iron only hydrogenase large subunit, C-terminal domain fn3_5 PF06280.12 EXF81709.1 - 0.03 15.0 1.0 0.12 13.1 0.0 2.5 3 1 0 3 3 3 0 Fn3-like domain PhoD PF09423.10 EXF81711.1 - 1.5e-44 152.5 0.0 2.3e-44 151.8 0.0 1.3 1 0 0 1 1 1 1 PhoD-like phosphatase EMP24_GP25L PF01105.24 EXF81712.1 - 1.2e-44 152.5 1.3 1.2e-44 152.5 1.3 3.5 3 0 0 3 3 3 2 emp24/gp25L/p24 family/GOLD Chromo PF00385.24 EXF81712.1 - 0.0024 17.7 0.4 0.0069 16.3 0.4 1.8 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain MPS2 PF17060.5 EXF81712.1 - 0.0024 17.2 4.5 0.0024 17.2 4.5 2.9 2 1 0 3 3 3 2 Monopolar spindle protein 2 V_ATPase_I PF01496.19 EXF81712.1 - 0.4 8.6 17.8 0.88 7.4 17.8 1.5 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF1664 PF07889.12 EXF81712.1 - 0.56 10.3 16.4 0.081 13.0 1.9 3.5 2 1 0 3 3 3 0 Protein of unknown function (DUF1664) FlaC_arch PF05377.11 EXF81712.1 - 1.2 9.6 14.9 1.7 9.1 0.4 3.9 4 0 0 4 4 4 0 Flagella accessory protein C (FlaC) cwf21 PF08312.12 EXF81712.1 - 1.7 8.9 5.2 5.8 7.1 0.9 3.0 2 0 0 2 2 2 0 cwf21 domain DUF489 PF04356.12 EXF81712.1 - 1.9 8.4 10.9 6.7 6.7 2.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF489) Tropomyosin PF00261.20 EXF81712.1 - 5.7 6.2 42.2 11 5.3 42.2 1.5 1 0 0 1 1 1 0 Tropomyosin Spc29 PF17082.5 EXF81712.1 - 10 5.9 29.8 0.18 11.6 7.5 4.2 2 1 1 3 3 3 0 Spindle Pole Component 29 COX5A PF02284.16 EXF81713.1 - 5.9e-41 138.7 0.1 7.3e-41 138.4 0.1 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Va ELO PF01151.18 EXF81714.1 - 4.2e-63 213.2 15.3 5e-63 212.9 15.3 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family Porphobil_deam PF01379.20 EXF81716.1 - 1.5e-75 253.2 0.0 2.4e-75 252.6 0.0 1.3 1 0 0 1 1 1 1 Porphobilinogen deaminase, dipyromethane cofactor binding domain Porphobil_deamC PF03900.15 EXF81716.1 - 9.2e-18 64.4 0.2 1.7e-17 63.5 0.2 1.5 1 0 0 1 1 1 1 Porphobilinogen deaminase, C-terminal domain GCV_H PF01597.19 EXF81717.1 - 9.6e-36 122.4 1.9 1.2e-35 122.1 1.9 1.1 1 0 0 1 1 1 1 Glycine cleavage H-protein Biotin_lipoyl PF00364.22 EXF81717.1 - 0.052 13.4 0.9 0.081 12.8 0.2 1.7 2 0 0 2 2 2 0 Biotin-requiring enzyme RnfC_N PF13375.6 EXF81717.1 - 0.058 13.3 0.1 0.082 12.9 0.1 1.3 1 0 0 1 1 1 0 RnfC Barrel sandwich hybrid domain Ras PF00071.22 EXF81718.1 - 1.4e-31 109.3 0.1 1.8e-31 108.9 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EXF81718.1 - 4.2e-24 85.1 0.1 7.6e-24 84.2 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EXF81718.1 - 1.3e-06 28.0 0.0 1.7e-06 27.6 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EXF81718.1 - 0.00022 20.7 0.1 0.00029 20.3 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region DLIC PF05783.11 EXF81718.1 - 0.0019 17.1 0.3 0.17 10.7 0.0 2.1 1 1 1 2 2 2 2 Dynein light intermediate chain (DLIC) PNTB PF02233.16 EXF81719.1 - 6.7e-175 582.4 29.0 6.7e-175 582.4 29.0 2.1 2 0 0 2 2 2 1 NAD(P) transhydrogenase beta subunit AlaDh_PNT_C PF01262.21 EXF81719.1 - 2.9e-74 249.0 0.1 8.7e-74 247.4 0.1 1.9 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain AlaDh_PNT_N PF05222.15 EXF81719.1 - 7.3e-48 162.3 0.0 1.8e-47 161.1 0.0 1.7 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain PNTB_4TM PF12769.7 EXF81719.1 - 1.8e-30 105.2 2.5 1.8e-30 105.2 2.5 5.2 4 1 1 5 5 5 1 4TM region of pyridine nucleotide transhydrogenase, mitoch 2-Hacid_dh_C PF02826.19 EXF81719.1 - 0.0011 18.3 0.1 0.63 9.4 0.0 2.5 2 0 0 2 2 2 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyr_redox_2 PF07992.14 EXF81719.1 - 0.0066 15.7 0.8 0.035 13.3 0.2 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase ADH_zinc_N PF00107.26 EXF81719.1 - 0.014 15.4 0.1 0.087 12.8 0.1 2.5 1 1 0 1 1 1 0 Zinc-binding dehydrogenase NAD_binding_8 PF13450.6 EXF81719.1 - 0.077 13.2 3.2 0.48 10.7 1.7 3.3 3 1 0 3 3 3 0 NAD(P)-binding Rossmann-like domain Fumerase PF05681.14 EXF81719.1 - 0.12 11.8 0.1 0.22 10.9 0.1 1.3 1 0 0 1 1 1 0 Fumarate hydratase (Fumerase) PRIMA1 PF16101.5 EXF81719.1 - 1.1 9.3 5.0 4.2 7.4 5.0 2.0 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Cytochrom_B561 PF03188.16 EXF81719.1 - 4.6 7.4 8.4 0.71 10.0 2.6 2.7 3 0 0 3 3 3 0 Eukaryotic cytochrome b561 Fungal_trans PF04082.18 EXF81720.1 - 2.8e-09 36.4 0.0 6.5e-09 35.2 0.0 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF81720.1 - 2.9e-08 33.7 11.5 2.9e-08 33.7 11.5 1.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ABC_membrane PF00664.23 EXF81721.1 - 2e-87 293.3 37.0 6.2e-44 150.7 15.7 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EXF81721.1 - 4e-70 234.7 0.0 1.5e-34 119.4 0.0 2.5 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EXF81721.1 - 7.6e-15 54.9 0.3 6.6e-05 22.4 0.0 4.2 3 1 1 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EXF81721.1 - 1.4e-08 34.3 0.2 0.0033 17.1 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EXF81721.1 - 8.9e-08 32.2 0.0 0.0079 16.1 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_22 PF13401.6 EXF81721.1 - 1.3e-07 32.0 0.3 0.0049 17.1 0.0 3.8 2 2 0 2 2 2 2 AAA domain Zeta_toxin PF06414.12 EXF81721.1 - 2.1e-07 30.5 0.0 0.011 15.1 0.0 3.3 3 0 0 3 3 3 2 Zeta toxin ABC_ATPase PF09818.9 EXF81721.1 - 2.8e-07 29.7 0.6 0.061 12.1 0.0 3.9 4 0 0 4 4 4 2 Predicted ATPase of the ABC class AAA_15 PF13175.6 EXF81721.1 - 1.7e-06 28.0 0.0 0.048 13.4 0.0 2.2 2 0 0 2 2 2 2 AAA ATPase domain AAA_16 PF13191.6 EXF81721.1 - 6.4e-06 26.7 5.2 0.0024 18.3 0.2 3.7 4 1 0 4 4 2 2 AAA ATPase domain AAA_30 PF13604.6 EXF81721.1 - 1e-05 25.4 2.6 0.036 13.8 0.0 3.7 4 1 0 4 4 3 2 AAA domain AAA_25 PF13481.6 EXF81721.1 - 1.9e-05 24.3 0.2 0.23 11.0 0.1 3.0 2 0 0 2 2 2 2 AAA domain AAA_21 PF13304.6 EXF81721.1 - 0.00011 22.2 1.6 1.3 8.7 0.2 4.4 3 1 0 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system G-alpha PF00503.20 EXF81721.1 - 0.0004 19.6 0.0 0.48 9.5 0.0 2.2 2 0 0 2 2 2 2 G-protein alpha subunit AAA_7 PF12775.7 EXF81721.1 - 0.00061 19.3 0.3 1.2 8.7 0.0 3.3 3 0 0 3 3 3 1 P-loop containing dynein motor region APS_kinase PF01583.20 EXF81721.1 - 0.00079 19.3 0.1 2.5 8.0 0.0 3.0 3 0 0 3 3 3 2 Adenylylsulphate kinase AAA_33 PF13671.6 EXF81721.1 - 0.0016 18.6 0.0 0.94 9.6 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_23 PF13476.6 EXF81721.1 - 0.0024 18.4 0.0 1.1 9.7 0.1 2.5 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 EXF81721.1 - 0.0034 17.4 0.4 6.5 6.8 0.0 3.7 4 0 0 4 4 4 0 AAA domain (dynein-related subfamily) Rad17 PF03215.15 EXF81721.1 - 0.0047 16.9 0.0 0.062 13.2 0.0 2.2 2 0 0 2 2 2 1 Rad17 P-loop domain RrnaAD PF00398.20 EXF81721.1 - 0.0058 15.7 0.0 0.022 13.9 0.0 1.8 2 0 0 2 2 2 1 Ribosomal RNA adenine dimethylase SbcCD_C PF13558.6 EXF81721.1 - 0.009 16.2 1.5 5.3 7.4 0.1 3.6 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit PRK PF00485.18 EXF81721.1 - 0.0098 15.7 0.1 3.2 7.4 0.0 2.8 3 0 0 3 3 2 1 Phosphoribulokinase / Uridine kinase family AAA_14 PF13173.6 EXF81721.1 - 0.025 14.6 0.0 16 5.6 0.0 3.6 4 0 0 4 4 4 0 AAA domain MMR_HSR1 PF01926.23 EXF81721.1 - 0.031 14.4 0.2 5.6 7.1 0.0 2.8 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA PF00004.29 EXF81721.1 - 0.043 14.2 2.3 5.2 7.5 0.3 4.0 2 2 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Ploopntkinase3 PF18751.1 EXF81721.1 - 0.044 13.7 0.1 1.7 8.5 0.0 2.4 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 AAA_24 PF13479.6 EXF81721.1 - 0.046 13.5 0.2 3.9 7.2 0.0 2.4 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 EXF81721.1 - 0.047 12.9 0.2 2.8 7.0 0.0 2.3 2 0 0 2 2 2 0 NB-ARC domain DUF87 PF01935.17 EXF81721.1 - 0.051 13.7 1.2 3.3 7.8 0.4 2.7 3 0 0 3 3 2 0 Helicase HerA, central domain SRP54 PF00448.22 EXF81721.1 - 0.073 12.7 0.4 13 5.4 0.0 2.4 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain DUF815 PF05673.13 EXF81721.1 - 0.085 12.0 0.0 5.6 6.1 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) ATP-synt_ab PF00006.25 EXF81721.1 - 0.13 11.9 0.0 7.5 6.1 0.0 2.7 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain RNA_helicase PF00910.22 EXF81721.1 - 0.16 12.3 0.2 7.3 7.0 0.0 2.5 2 0 0 2 2 2 0 RNA helicase DUF2628 PF10947.8 EXF81721.1 - 0.8 10.1 4.2 0.64 10.4 0.5 2.9 2 0 0 2 2 1 0 Protein of unknown function (DUF2628) AAA_28 PF13521.6 EXF81721.1 - 0.9 9.8 5.7 0.93 9.7 0.0 2.8 3 0 0 3 3 2 0 AAA domain DUF2207 PF09972.9 EXF81721.1 - 1.3 7.7 9.7 2.2 7.0 0.0 2.8 3 0 0 3 3 3 0 Predicted membrane protein (DUF2207) Alk_phosphatase PF00245.20 EXF81722.1 - 1.1e-72 245.2 0.2 4.4e-72 243.3 0.2 1.9 1 1 0 1 1 1 1 Alkaline phosphatase Phosphodiest PF01663.22 EXF81722.1 - 2.1e-07 30.9 0.0 3.3e-07 30.2 0.0 1.4 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 EXF81722.1 - 3.4e-07 30.0 0.0 5.4e-07 29.3 0.0 1.4 1 0 0 1 1 1 1 Sulfatase DUF229 PF02995.17 EXF81722.1 - 0.00011 21.0 0.4 0.00019 20.2 0.2 1.4 2 0 0 2 2 2 1 Protein of unknown function (DUF229) DUF1501 PF07394.12 EXF81722.1 - 0.017 14.2 0.1 0.026 13.6 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) CutC PF03932.14 EXF81723.1 - 6.6e-34 117.2 0.0 1e-33 116.5 0.0 1.3 1 0 0 1 1 1 1 CutC family PGP_phosphatase PF09419.10 EXF81724.1 - 3.4e-65 218.8 0.0 3.9e-65 218.5 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial PGP phosphatase Hydrolase_like PF13242.6 EXF81724.1 - 4.9e-05 23.3 0.0 8.3e-05 22.6 0.0 1.6 1 1 0 1 1 1 1 HAD-hyrolase-like MTHFR PF02219.17 EXF81724.1 - 0.0032 16.8 0.0 0.0043 16.4 0.0 1.1 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase Hydrolase PF00702.26 EXF81724.1 - 0.11 12.7 0.0 0.17 12.2 0.0 1.3 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase ORC2 PF04084.14 EXF81725.1 - 2.5e-116 388.2 0.0 3.1e-116 387.9 0.0 1.1 1 0 0 1 1 1 1 Origin recognition complex subunit 2 Elong_Iki1 PF10483.9 EXF81725.1 - 0.0038 16.8 5.5 0.3 10.5 0.1 2.2 2 0 0 2 2 2 2 Elongator subunit Iki1 dbPDZ_assoc PF16610.5 EXF81725.1 - 0.008 16.4 0.2 0.008 16.4 0.2 3.1 2 2 0 2 2 2 1 Unstructured region between two PDZ domains on Dlg5 DUF1754 PF08555.10 EXF81728.1 - 8.9e-07 29.6 27.8 0.00023 21.9 27.8 2.2 1 1 0 1 1 1 1 Eukaryotic family of unknown function (DUF1754) Cytomega_UL84 PF06284.11 EXF81728.1 - 0.37 9.2 8.8 0.44 8.9 8.8 1.2 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein Cwf_Cwc_15 PF04889.12 EXF81728.1 - 0.45 10.2 20.4 0.59 9.8 20.4 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Smg8_Smg9 PF10220.9 EXF81728.1 - 1.3 7.2 6.0 1.5 7.1 6.0 1.0 1 0 0 1 1 1 0 Smg8_Smg9 Nop14 PF04147.12 EXF81728.1 - 3.1 5.9 19.8 3.8 5.6 19.8 1.1 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 EXF81728.1 - 3.2 5.9 18.5 3.9 5.6 18.5 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF913 PF06025.12 EXF81728.1 - 5 6.0 6.7 5.8 5.8 6.7 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF3245 PF11595.8 EXF81728.1 - 8 6.9 22.5 14 6.1 22.5 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3245) Adaptin_binding PF10199.9 EXF81728.1 - 8 7.1 15.1 16 6.1 15.1 1.5 1 1 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 AA_permease_2 PF13520.6 EXF81729.1 - 2.7e-60 204.4 41.1 3.7e-60 203.9 41.1 1.2 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EXF81729.1 - 7.1e-30 104.0 27.6 7.1e-30 104.0 27.6 1.9 2 0 0 2 2 2 1 Amino acid permease 2-Hacid_dh_C PF02826.19 EXF81730.1 - 1e-51 174.9 0.0 1.7e-51 174.1 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EXF81730.1 - 1.5e-15 57.0 0.0 2.3e-15 56.4 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 EXF81730.1 - 5.4e-05 23.4 0.0 0.00013 22.1 0.0 1.6 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase AlaDh_PNT_C PF01262.21 EXF81730.1 - 0.0067 15.8 0.2 0.32 10.2 0.0 2.2 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain SKG6 PF08693.10 EXF81734.1 - 0.00024 20.5 5.4 0.0009 18.6 5.4 2.0 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Podoplanin PF05808.11 EXF81734.1 - 0.0015 18.6 5.6 0.0034 17.5 5.6 1.6 1 0 0 1 1 1 1 Podoplanin Mucin PF01456.17 EXF81734.1 - 0.003 17.6 18.0 0.003 17.6 18.0 3.0 3 0 0 3 3 3 1 Mucin-like glycoprotein Na_Ca_ex PF01699.24 EXF81734.1 - 0.28 11.1 4.2 0.44 10.5 4.2 1.2 1 0 0 1 1 1 0 Sodium/calcium exchanger protein PRIMA1 PF16101.5 EXF81737.1 - 0.7 9.9 5.3 0.92 9.6 5.3 1.3 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 CAP_N PF01213.19 EXF81737.1 - 3.8 6.9 11.0 5.7 6.3 11.0 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal DAO PF01266.24 EXF81738.1 - 1.4e-49 169.6 0.0 2.1e-49 169.0 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO_C PF16901.5 EXF81738.1 - 6.2e-39 132.7 0.0 2.2e-38 131.0 0.0 1.9 2 0 0 2 2 2 1 C-terminal domain of alpha-glycerophosphate oxidase FAD_binding_2 PF00890.24 EXF81738.1 - 1.9e-07 30.6 2.0 0.0054 15.9 1.2 2.3 2 0 0 2 2 2 2 FAD binding domain FAD_oxidored PF12831.7 EXF81738.1 - 3.1e-06 26.8 0.3 0.00039 19.9 0.3 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EXF81738.1 - 0.00097 18.4 0.0 0.002 17.4 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EXF81738.1 - 0.0061 16.8 0.3 0.27 11.5 0.2 3.2 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 EXF81738.1 - 0.022 14.1 0.0 0.055 12.7 0.0 1.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 EXF81738.1 - 0.028 14.3 0.1 0.054 13.4 0.1 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GIDA PF01134.22 EXF81738.1 - 0.043 12.9 0.1 0.2 10.7 0.1 1.9 2 0 0 2 2 2 0 Glucose inhibited division protein A HI0933_like PF03486.14 EXF81738.1 - 0.078 11.7 0.2 0.12 11.0 0.2 1.2 1 0 0 1 1 1 0 HI0933-like protein Pyr_redox PF00070.27 EXF81738.1 - 0.15 12.6 0.2 0.49 11.0 0.2 1.9 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EXF81738.1 - 0.37 10.0 1.1 1.5 8.0 0.1 2.4 3 0 0 3 3 3 0 Thi4 family MIP PF00230.20 EXF81739.1 - 1.2e-52 178.9 8.0 1.5e-52 178.6 8.0 1.0 1 0 0 1 1 1 1 Major intrinsic protein G3P_acyltransf PF02660.15 EXF81739.1 - 0.18 11.8 10.1 0.38 10.8 10.1 1.5 1 1 0 1 1 1 0 Glycerol-3-phosphate acyltransferase FGGY_C PF02782.16 EXF81740.1 - 4e-72 242.1 0.9 6.8e-72 241.4 0.9 1.4 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 EXF81740.1 - 2.8e-65 220.3 0.0 3.6e-65 219.9 0.0 1.1 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain BcrAD_BadFG PF01869.20 EXF81740.1 - 0.046 13.2 0.2 1.2 8.6 0.0 2.2 2 0 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family HTH_IclR PF09339.10 EXF81740.1 - 0.11 12.3 0.1 0.68 9.8 0.0 2.3 2 0 0 2 2 2 0 IclR helix-turn-helix domain Fungal_trans PF04082.18 EXF81742.1 - 9.5e-19 67.5 0.2 1.6e-18 66.7 0.2 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF81742.1 - 3.4e-08 33.5 11.2 6.6e-08 32.5 10.2 2.0 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Gelsolin PF00626.22 EXF81743.1 - 3.4e-34 116.6 0.3 5.5e-12 45.4 0.0 3.3 3 0 0 3 3 3 3 Gelsolin repeat Flu_NP PF00506.18 EXF81745.1 - 0.11 11.1 0.0 0.16 10.6 0.0 1.1 1 0 0 1 1 1 0 Influenza virus nucleoprotein Cu-oxidase_2 PF07731.14 EXF81747.1 - 3.3e-28 98.1 5.0 2.5e-26 92.1 2.4 2.6 2 0 0 2 2 2 2 Multicopper oxidase Cu-oxidase_3 PF07732.15 EXF81747.1 - 4.7e-19 68.5 0.8 1.8e-18 66.6 0.1 2.2 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase PF00394.22 EXF81747.1 - 4.2e-07 30.2 0.2 2.1e-05 24.7 0.0 3.3 4 0 0 4 4 4 1 Multicopper oxidase Macoilin PF09726.9 EXF81747.1 - 0.49 8.9 5.8 0.66 8.5 5.8 1.1 1 0 0 1 1 1 0 Macoilin family FSA_C PF10479.9 EXF81747.1 - 6.7 4.7 10.5 9.4 4.2 10.5 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Ank_2 PF12796.7 EXF81749.1 - 4.9e-23 81.5 0.2 2e-08 34.7 0.0 5.1 1 1 4 5 5 5 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EXF81749.1 - 4e-15 56.0 1.8 0.00011 22.7 0.0 5.6 4 2 2 6 6 6 4 Ankyrin repeats (many copies) Ank PF00023.30 EXF81749.1 - 1.1e-13 50.9 0.8 0.0051 17.2 0.0 7.2 7 1 0 7 7 7 2 Ankyrin repeat Ank_3 PF13606.6 EXF81749.1 - 1.6e-12 46.4 5.6 0.12 12.9 0.0 8.5 10 0 0 10 10 10 2 Ankyrin repeat Ank_5 PF13857.6 EXF81749.1 - 1.4e-10 41.2 1.3 0.13 12.7 0.0 6.1 5 2 2 7 7 7 3 Ankyrin repeats (many copies) ZZ PF00569.17 EXF81749.1 - 5.4e-06 26.1 7.8 1.2e-05 25.0 7.8 1.5 1 0 0 1 1 1 1 Zinc finger, ZZ type C1_2 PF03107.16 EXF81749.1 - 0.13 12.6 7.0 0.28 11.5 7.0 1.6 1 0 0 1 1 1 0 C1 domain DIOX_N PF14226.6 EXF81750.1 - 7.3e-21 75.1 0.0 2.9e-20 73.2 0.0 2.0 2 0 0 2 2 2 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EXF81750.1 - 2.9e-11 43.7 0.0 4.9e-11 43.0 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily MFS_1 PF07690.16 EXF81751.1 - 4.1e-21 75.3 28.7 4.1e-21 75.3 28.7 1.7 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1 PF07690.16 EXF81752.1 - 1.6e-32 112.8 31.6 1.6e-32 112.8 31.6 1.7 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF81752.1 - 4.3e-09 35.8 9.6 4.3e-09 35.8 9.6 3.0 2 2 1 3 3 3 2 Sugar (and other) transporter TRI12 PF06609.13 EXF81752.1 - 0.0001 20.9 1.3 0.00016 20.2 1.3 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Abhydrolase_6 PF12697.7 EXF81754.1 - 1.2e-14 55.4 1.4 1.4e-14 55.2 1.4 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.7 EXF81754.1 - 0.0087 15.8 0.1 0.016 15.0 0.1 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EXF81754.1 - 0.0098 15.2 0.0 0.016 14.5 0.0 1.4 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_8 PF06259.12 EXF81754.1 - 0.026 14.2 0.7 0.055 13.1 0.6 1.6 1 1 1 2 2 2 0 Alpha/beta hydrolase 3Beta_HSD PF01073.19 EXF81755.1 - 8.9e-10 38.0 0.0 1.6e-09 37.2 0.0 1.4 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EXF81755.1 - 2.2e-09 37.2 0.0 2.1e-08 34.0 0.0 2.1 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EXF81755.1 - 2.7e-08 33.9 0.1 8.5e-08 32.3 0.1 1.8 2 1 0 2 2 2 1 NAD(P)H-binding NAD_binding_4 PF07993.12 EXF81755.1 - 0.00017 20.9 0.0 0.017 14.3 0.0 2.1 2 0 0 2 2 2 2 Male sterility protein NmrA PF05368.13 EXF81755.1 - 0.00018 21.1 0.0 0.00059 19.5 0.1 1.9 2 1 0 2 2 2 1 NmrA-like family GDP_Man_Dehyd PF16363.5 EXF81755.1 - 0.0017 17.8 0.0 0.0023 17.4 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 EXF81755.1 - 0.026 13.6 0.0 0.039 13.0 0.0 1.3 1 0 0 1 1 1 0 RmlD substrate binding domain Aldedh PF00171.22 EXF81756.1 - 9.1e-127 423.4 0.0 1.1e-126 423.0 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 EXF81756.1 - 0.0018 17.4 1.6 0.0083 15.2 1.6 1.9 1 1 0 1 1 1 1 Acyl-CoA reductase (LuxC) DUF5633 PF18656.1 EXF81756.1 - 0.16 11.9 0.6 0.37 10.7 0.6 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5633) Tai4 PF16695.5 EXF81756.1 - 0.24 11.9 0.9 0.6 10.7 0.2 2.0 2 0 0 2 2 2 0 Type VI secretion system (T6SS), amidase immunity protein Ald_Xan_dh_C2 PF02738.18 EXF81757.1 - 4.6e-205 682.2 0.1 6.6e-205 681.7 0.1 1.2 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase FAD_binding_5 PF00941.21 EXF81757.1 - 1e-47 162.0 0.0 2.4e-47 160.9 0.0 1.6 1 0 0 1 1 1 1 FAD binding domain in molybdopterin dehydrogenase Ald_Xan_dh_C PF01315.22 EXF81757.1 - 7.6e-33 113.2 0.1 1.6e-32 112.1 0.1 1.6 1 0 0 1 1 1 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain CO_deh_flav_C PF03450.17 EXF81757.1 - 1.5e-30 105.4 0.9 3.9e-30 104.1 0.1 2.2 2 0 0 2 2 2 1 CO dehydrogenase flavoprotein C-terminal domain Fer2_2 PF01799.20 EXF81757.1 - 3.7e-30 103.8 0.0 7.7e-30 102.7 0.0 1.6 1 0 0 1 1 1 1 [2Fe-2S] binding domain Fer2 PF00111.27 EXF81757.1 - 7e-08 32.3 0.1 7e-08 32.3 0.1 2.3 3 0 0 3 3 3 1 2Fe-2S iron-sulfur cluster binding domain DUF218 PF02698.17 EXF81757.1 - 0.026 14.6 0.1 0.085 12.9 0.1 1.8 1 0 0 1 1 1 0 DUF218 domain PAS PF00989.25 EXF81758.1 - 0.063 13.3 0.0 0.13 12.3 0.0 1.5 1 0 0 1 1 1 0 PAS fold DUF104 PF01954.16 EXF81758.1 - 0.2 12.1 0.1 0.41 11.1 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function DUF104 SPO22 PF08631.10 EXF81759.1 - 6.6e-76 255.4 1.2 2.2e-72 243.8 0.0 3.5 3 0 0 3 3 3 3 Meiosis protein SPO22/ZIP4 like TPR_19 PF14559.6 EXF81759.1 - 0.0097 16.4 0.1 0.052 14.1 0.1 2.4 1 0 0 1 1 1 1 Tetratricopeptide repeat Pyridoxal_deC PF00282.19 EXF81760.1 - 3.4e-76 256.4 0.0 4.3e-76 256.0 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain DegT_DnrJ_EryC1 PF01041.17 EXF81760.1 - 0.016 14.5 0.7 0.045 13.0 0.1 1.9 2 1 0 2 2 2 0 DegT/DnrJ/EryC1/StrS aminotransferase family DUF3464 PF11947.8 EXF81760.1 - 0.09 12.5 0.0 0.19 11.4 0.0 1.6 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 DUF4431 PF14485.6 EXF81760.1 - 0.13 12.1 0.0 0.41 10.5 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4431) Ufd2P_core PF10408.9 EXF81761.1 - 2.2e-214 713.7 12.4 2.8e-214 713.3 12.4 1.1 1 0 0 1 1 1 1 Ubiquitin elongating factor core U-box PF04564.15 EXF81761.1 - 1.1e-25 89.6 1.1 3.7e-25 87.9 1.1 2.0 1 0 0 1 1 1 1 U-box domain zf-TRAF PF02176.18 EXF81762.1 - 3.1e-09 37.4 37.6 4.8e-09 36.8 7.8 4.1 2 1 2 4 4 3 2 TRAF-type zinc finger zf-C3HC4_3 PF13920.6 EXF81762.1 - 1.6e-07 31.1 4.9 1.6e-07 31.1 4.9 3.5 2 1 1 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EXF81762.1 - 5.6e-06 26.1 10.0 5.6e-06 26.1 10.0 3.9 2 1 3 5 5 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EXF81762.1 - 6.3e-06 26.4 9.1 6.3e-06 26.4 9.1 4.4 2 1 2 4 4 3 1 Ring finger domain zf-C3HC4 PF00097.25 EXF81762.1 - 1.2e-05 25.0 10.1 1.2e-05 25.0 10.1 3.3 2 1 1 3 3 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EXF81762.1 - 1.9e-05 24.6 13.7 8.5e-05 22.5 12.9 2.6 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 EXF81762.1 - 2.2e-05 24.3 6.6 2.2e-05 24.3 6.6 3.4 2 2 0 2 2 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EXF81762.1 - 3.3e-05 23.7 8.1 3.3e-05 23.7 8.1 2.8 3 1 0 3 3 2 1 Prokaryotic RING finger family 4 zf-TRAF_2 PF15965.5 EXF81762.1 - 0.00016 22.1 30.0 0.0011 19.4 10.5 3.3 1 1 3 4 4 4 2 TRAF-like zinc-finger Sina PF03145.16 EXF81762.1 - 0.00073 19.5 9.1 0.0072 16.3 1.2 3.6 2 2 2 4 4 4 2 Seven in absentia protein family zf-C3HC4_4 PF15227.6 EXF81762.1 - 0.00074 19.6 6.5 0.00074 19.6 6.5 2.6 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.7 EXF81762.1 - 0.0035 17.6 7.4 0.0035 17.6 7.4 4.3 2 2 2 4 4 2 1 RING-H2 zinc finger domain U-box PF04564.15 EXF81762.1 - 0.016 15.4 0.6 0.085 13.0 0.4 2.3 2 0 0 2 2 2 0 U-box domain PRP1_N PF06424.12 EXF81762.1 - 0.051 14.0 0.9 0.11 12.9 0.9 1.5 1 0 0 1 1 1 0 PRP1 splicing factor, N-terminal zf_C2HC_14 PF18574.1 EXF81762.1 - 0.1 12.4 0.1 0.1 12.4 0.1 4.2 4 1 1 5 5 5 0 C2HC Zing finger domain zf_C2H2_13 PF18508.1 EXF81762.1 - 0.24 11.0 5.5 1.2 8.8 0.8 2.8 2 0 0 2 2 2 0 Zinc finger domain BLOC1_2 PF10046.9 EXF81762.1 - 0.28 11.5 3.2 1.5 9.2 0.1 2.5 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 zf-P11 PF03854.14 EXF81762.1 - 0.46 10.2 11.4 0.43 10.3 3.0 2.9 1 1 1 2 2 2 0 P-11 zinc finger DivIC PF04977.15 EXF81762.1 - 0.47 10.3 3.4 1 9.2 1.6 2.2 2 0 0 2 2 2 0 Septum formation initiator Spc7 PF08317.11 EXF81762.1 - 0.56 9.0 6.4 5.3 5.8 2.1 2.2 2 0 0 2 2 2 0 Spc7 kinetochore protein GAS PF13851.6 EXF81762.1 - 2.1 7.6 12.2 0.32 10.3 4.9 2.4 2 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding SlyX PF04102.12 EXF81762.1 - 5.8 7.6 7.5 2.7 8.7 1.3 3.0 2 1 0 2 2 2 0 SlyX Pyr_redox_2 PF07992.14 EXF81763.1 - 8.8e-14 51.4 0.0 2.7e-09 36.7 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EXF81763.1 - 4.2e-11 42.7 0.0 8.5e-11 41.7 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 EXF81763.1 - 8.9e-11 40.9 0.0 1.4e-10 40.3 0.0 1.2 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like K_oxygenase PF13434.6 EXF81763.1 - 2e-06 27.2 0.0 6e-06 25.6 0.0 1.7 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox PF00070.27 EXF81763.1 - 5.7e-05 23.6 0.6 0.41 11.2 0.1 2.8 3 0 0 3 3 2 2 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EXF81763.1 - 0.00095 18.3 0.5 0.01 14.9 0.4 2.5 3 1 0 3 3 3 1 Lycopene cyclase protein NAD_binding_8 PF13450.6 EXF81763.1 - 0.0018 18.5 0.1 0.0065 16.7 0.1 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 EXF81763.1 - 0.0034 16.7 0.3 0.008 15.5 0.1 1.7 2 0 0 2 2 2 1 FAD binding domain HI0933_like PF03486.14 EXF81763.1 - 0.012 14.4 1.1 0.62 8.7 0.1 2.8 3 0 0 3 3 3 0 HI0933-like protein 2-Hacid_dh_C PF02826.19 EXF81763.1 - 0.014 14.8 0.0 0.49 9.7 0.0 2.3 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain PS_pyruv_trans PF04230.13 EXF81763.1 - 0.15 12.0 0.0 0.47 10.3 0.0 1.8 2 0 0 2 2 2 0 Polysaccharide pyruvyl transferase TrkA_N PF02254.18 EXF81763.1 - 0.17 12.1 0.0 0.41 10.9 0.0 1.6 1 0 0 1 1 1 0 TrkA-N domain NAD_binding_9 PF13454.6 EXF81763.1 - 0.21 11.6 0.6 15 5.6 0.0 2.9 3 0 0 3 3 3 0 FAD-NAD(P)-binding AAA PF00004.29 EXF81764.1 - 8.3e-17 61.9 0.0 1.4e-16 61.1 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Transp_cyt_pur PF02133.15 EXF81765.1 - 1.1e-98 330.9 34.5 1.5e-98 330.5 34.5 1.1 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Fungal_trans PF04082.18 EXF81765.1 - 1.2e-21 77.0 0.3 2.1e-21 76.1 0.3 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain DUF917 PF06032.12 EXF81766.1 - 6.1e-115 383.8 0.0 1.1e-114 383.0 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF917) Hydant_A_N PF05378.13 EXF81766.1 - 5.2e-29 101.2 4.2 7.1e-26 91.0 0.2 3.6 3 1 0 3 3 3 2 Hydantoinase/oxoprolinase N-terminal region Hydantoinase_A PF01968.18 EXF81766.1 - 8e-23 81.1 10.6 1.1e-19 70.8 7.1 4.1 2 1 0 2 2 2 1 Hydantoinase/oxoprolinase MutL PF13941.6 EXF81766.1 - 2.4e-05 23.2 3.1 0.026 13.1 0.0 2.6 2 0 0 2 2 2 2 MutL protein StbA PF06406.11 EXF81766.1 - 0.0003 20.1 0.3 0.19 11.0 0.1 2.4 2 0 0 2 2 2 2 StbA protein BcrAD_BadFG PF01869.20 EXF81766.1 - 0.032 13.7 6.1 0.29 10.6 1.1 2.5 2 1 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family ROK PF00480.20 EXF81766.1 - 0.051 13.1 1.8 0.066 12.7 0.5 1.9 2 0 0 2 2 2 0 ROK family DUF3663 PF12404.8 EXF81766.1 - 0.11 12.6 0.0 0.24 11.5 0.0 1.5 1 0 0 1 1 1 0 Peptidase FtsA PF14450.6 EXF81766.1 - 0.24 11.8 2.5 31 5.1 0.7 3.5 3 1 0 3 3 3 0 Cell division protein FtsA NPR3 PF03666.13 EXF81767.1 - 5.4 5.7 8.0 12 4.6 8.0 1.5 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 CNDH2_M PF16869.5 EXF81768.1 - 0.16 12.7 1.1 0.29 11.8 1.1 1.4 1 0 0 1 1 1 0 PF16858 F-box PF00646.33 EXF81769.1 - 0.019 14.8 0.2 0.048 13.5 0.2 1.7 1 0 0 1 1 1 0 F-box domain F-box-like PF12937.7 EXF81769.1 - 0.048 13.5 1.9 0.087 12.7 0.5 2.2 2 0 0 2 2 2 0 F-box-like 2OG-FeII_Oxy_3 PF13640.6 EXF81770.1 - 3.7e-09 37.3 0.5 1.8e-08 35.2 0.2 2.3 3 0 0 3 3 3 1 2OG-Fe(II) oxygenase superfamily adh_short PF00106.25 EXF81771.1 - 1.3e-21 76.9 0.0 7e-18 64.8 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EXF81771.1 - 5.9e-11 42.4 0.0 2.6e-10 40.2 0.0 1.8 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF81771.1 - 1.4e-05 25.1 0.1 2.1e-05 24.5 0.1 1.2 1 0 0 1 1 1 1 KR domain Cofilin_ADF PF00241.20 EXF81772.1 - 2.8e-23 82.0 0.1 4e-23 81.5 0.1 1.2 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein POLO_box PF00659.18 EXF81775.1 - 0.1 12.8 0.4 0.18 12.0 0.4 1.3 1 0 0 1 1 1 0 POLO box duplicated region VEG PF06257.11 EXF81776.1 - 0.1 12.6 0.1 0.2 11.7 0.1 1.4 1 0 0 1 1 1 0 Biofilm formation stimulator VEG PatG_C PF18065.1 EXF81777.1 - 0.027 14.5 0.0 1.3 9.0 0.0 2.8 3 0 0 3 3 3 0 PatG C-terminal MFS_1 PF07690.16 EXF81778.1 - 2.1e-42 145.3 28.9 2.1e-42 145.3 28.9 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF81778.1 - 1.1e-14 54.2 5.0 1.1e-14 54.2 5.0 2.6 3 0 0 3 3 3 1 Sugar (and other) transporter TRI12 PF06609.13 EXF81778.1 - 9.5e-10 37.5 2.7 1.6e-09 36.8 2.7 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_3 PF05977.13 EXF81778.1 - 0.36 9.2 8.6 0.01 14.3 1.8 1.7 2 0 0 2 2 2 0 Transmembrane secretion effector MFS_1 PF07690.16 EXF81779.1 - 2.6e-29 102.3 29.0 4e-29 101.7 29.0 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Trp_oprn_chp PF09534.10 EXF81779.1 - 0.29 10.9 3.2 0.34 10.7 0.0 2.6 3 0 0 3 3 3 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) p450 PF00067.22 EXF81780.1 - 1.5e-63 215.2 0.0 1.8e-63 214.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Band_7 PF01145.25 EXF81781.1 - 2.7e-14 53.6 0.3 2.7e-14 53.6 0.3 3.5 3 2 0 3 3 3 1 SPFH domain / Band 7 family CFEM PF05730.11 EXF81782.1 - 1.9e-14 53.5 8.6 2.9e-14 52.9 8.6 1.3 1 0 0 1 1 1 1 CFEM domain adh_short PF00106.25 EXF81782.1 - 4.5e-06 26.3 0.0 7.5e-06 25.5 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EXF81782.1 - 0.00039 20.4 0.0 0.00075 19.5 0.0 1.4 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.6 EXF81782.1 - 0.00069 19.2 0.0 0.0012 18.5 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DAO PF01266.24 EXF81783.1 - 1.4e-36 126.8 0.2 1.7e-36 126.6 0.2 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EXF81783.1 - 3.6e-07 30.3 0.0 9.4e-07 29.0 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EXF81783.1 - 7.2e-06 25.3 0.1 0.0041 16.3 0.0 2.3 2 0 0 2 2 2 2 FAD binding domain Pyr_redox_2 PF07992.14 EXF81783.1 - 1.8e-05 24.1 0.1 0.0011 18.3 0.1 2.7 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EXF81783.1 - 0.00036 19.9 0.0 0.0012 18.1 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EXF81783.1 - 0.0044 16.3 0.0 0.0073 15.6 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain GIDA PF01134.22 EXF81783.1 - 0.0054 15.9 0.0 2.8 6.9 0.0 2.2 2 0 0 2 2 2 2 Glucose inhibited division protein A HI0933_like PF03486.14 EXF81783.1 - 0.0075 15.0 0.0 1.3 7.7 0.0 2.4 2 0 0 2 2 2 2 HI0933-like protein Pyr_redox PF00070.27 EXF81783.1 - 0.012 16.2 0.0 0.34 11.5 0.0 2.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Shikimate_DH PF01488.20 EXF81783.1 - 0.014 15.5 0.0 0.025 14.6 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase GMC_oxred_N PF00732.19 EXF81783.1 - 0.035 13.5 0.0 4.3 6.6 0.0 2.4 2 0 0 2 2 2 0 GMC oxidoreductase NAD_binding_9 PF13454.6 EXF81783.1 - 0.056 13.4 0.1 0.28 11.1 0.0 2.1 2 0 0 2 2 2 0 FAD-NAD(P)-binding DUF692 PF05114.13 EXF81783.1 - 0.072 12.3 0.0 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF692) TrkA_N PF02254.18 EXF81783.1 - 0.091 13.0 0.0 0.27 11.5 0.0 1.8 2 0 0 2 2 1 0 TrkA-N domain Glu_dehyd_C PF16912.5 EXF81783.1 - 0.16 11.5 0.0 0.5 9.8 0.0 1.8 2 0 0 2 2 2 0 Glucose dehydrogenase C-terminus Sugar_tr PF00083.24 EXF81784.1 - 2.3e-66 224.5 26.0 3e-66 224.1 26.0 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF81784.1 - 1.9e-19 69.8 44.0 1.5e-14 53.7 25.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily 2-Hacid_dh_C PF02826.19 EXF81785.1 - 5.4e-53 179.0 0.0 7.2e-53 178.6 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EXF81785.1 - 1.9e-18 66.4 0.0 2.4e-18 66.1 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 EXF81785.1 - 0.00088 19.5 0.0 0.0016 18.6 0.0 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase HypF_C PF17788.1 EXF81785.1 - 0.015 16.0 0.0 0.031 15.0 0.0 1.5 1 0 0 1 1 1 0 HypF Kae1-like domain EHD_N PF16880.5 EXF81785.1 - 0.079 12.9 0.1 0.16 11.9 0.1 1.5 1 0 0 1 1 1 0 N-terminal EH-domain containing protein Asp_Glu_race PF01177.22 EXF81786.1 - 0.02 14.8 0.0 1.7 8.5 0.0 2.1 2 0 0 2 2 2 0 Asp/Glu/Hydantoin racemase Aldolase_II PF00596.21 EXF81787.1 - 2.9e-48 164.3 0.0 3.6e-48 163.9 0.0 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain DUF1338 PF07063.13 EXF81788.1 - 2.8e-109 365.3 0.0 3.4e-109 365.0 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1338) ApbA_C PF08546.11 EXF81788.1 - 0.12 12.6 0.0 0.38 11.0 0.0 1.8 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA C terminal Abhydrolase_6 PF12697.7 EXF81788.1 - 0.18 12.4 0.7 0.97 10.0 0.2 2.0 1 1 0 2 2 2 0 Alpha/beta hydrolase family Fungal_trans PF04082.18 EXF81789.1 - 1.6e-29 102.7 0.0 2.8e-29 102.0 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF81789.1 - 4.7e-08 33.0 8.0 1e-07 32.0 8.0 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Glyco_hydro_71 PF03659.14 EXF81790.1 - 5.8e-132 440.0 0.4 8.5e-132 439.5 0.0 1.4 2 0 0 2 2 2 1 Glycosyl hydrolase family 71 DOCK_N PF16172.5 EXF81791.1 - 5.5e-125 417.2 0.0 9.2e-125 416.5 0.0 1.4 1 0 0 1 1 1 1 DOCK N-terminus DOCK-C2 PF14429.6 EXF81791.1 - 7.3e-38 130.3 0.0 1.5e-37 129.3 0.0 1.6 1 0 0 1 1 1 1 C2 domain in Dock180 and Zizimin proteins DHR-2 PF06920.13 EXF81791.1 - 5.4e-32 111.1 4.9 1.2e-30 106.7 4.9 2.7 1 1 0 1 1 1 1 Dock homology region 2 SH3_1 PF00018.28 EXF81791.1 - 0.00011 21.7 0.0 0.00026 20.5 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EXF81791.1 - 0.0045 16.8 0.0 0.024 14.5 0.0 2.2 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.17 EXF81791.1 - 0.04 13.6 0.0 0.26 11.0 0.0 2.3 2 0 0 2 2 2 0 Variant SH3 domain PAP2_3 PF14378.6 EXF81792.1 - 3.5e-35 121.4 15.0 4.9e-28 98.1 2.8 2.5 3 0 0 3 3 3 2 PAP2 superfamily PAP2 PF01569.21 EXF81792.1 - 0.0019 17.9 1.9 0.0019 17.9 1.9 2.6 2 1 0 2 2 2 1 PAP2 superfamily PAP2_C PF14360.6 EXF81792.1 - 0.28 11.7 4.5 0.6 10.7 0.1 2.8 2 0 0 2 2 2 0 PAP2 superfamily C-terminal Glyco_hydro_88 PF07470.13 EXF81793.1 - 2e-63 214.6 2.0 2.6e-63 214.2 2.0 1.0 1 0 0 1 1 1 1 Glycosyl Hydrolase Family 88 MFS_1 PF07690.16 EXF81794.1 - 2.6e-42 145.0 34.3 2.6e-42 145.0 34.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF81794.1 - 2.2e-13 49.9 5.7 3.8e-13 49.1 5.7 1.3 1 0 0 1 1 1 1 Sugar (and other) transporter TRI12 PF06609.13 EXF81794.1 - 1.1e-05 24.1 3.5 1.6e-05 23.5 3.5 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) OATP PF03137.20 EXF81794.1 - 0.13 10.5 3.6 15 3.7 0.0 2.7 2 1 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Fungal_trans PF04082.18 EXF81795.1 - 2.1e-10 40.1 0.0 2.9e-10 39.7 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Aminotran_5 PF00266.19 EXF81796.1 - 4.9e-32 111.3 0.0 1e-22 80.6 0.0 2.1 1 1 0 2 2 2 2 Aminotransferase class-V p450 PF00067.22 EXF81797.1 - 1.2e-51 175.9 0.0 2e-51 175.2 0.0 1.3 2 0 0 2 2 2 1 Cytochrome P450 SAMP PF05924.11 EXF81797.1 - 0.59 9.5 1.6 0.62 9.4 0.1 1.8 2 0 0 2 2 2 0 SAMP Motif Epimerase PF01370.21 EXF81798.1 - 8e-23 81.1 0.0 9.2e-23 81.0 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EXF81798.1 - 1.9e-18 67.0 0.6 9e-14 51.6 0.0 3.0 1 1 1 2 2 2 2 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 EXF81798.1 - 1.3e-08 34.4 0.8 1.1e-05 24.8 0.1 3.0 2 1 1 3 3 3 2 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 EXF81798.1 - 1.9e-08 33.8 0.0 1.5e-07 30.8 0.0 2.2 2 0 0 2 2 2 1 Male sterility protein RmlD_sub_bind PF04321.17 EXF81798.1 - 8.7e-08 31.6 0.0 1.1e-07 31.3 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain 3Beta_HSD PF01073.19 EXF81798.1 - 0.0035 16.4 0.0 0.0079 15.2 0.0 1.5 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family FSH1 PF03959.13 EXF81799.1 - 2.4e-29 102.5 0.0 3.1e-29 102.2 0.0 1.1 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_3 PF07859.13 EXF81799.1 - 0.0046 16.8 0.1 0.0075 16.1 0.1 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 EXF81799.1 - 0.028 14.2 0.2 0.1 12.4 0.0 1.9 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Melibiase_2 PF16499.5 EXF81802.1 - 1.1e-47 162.6 0.2 2.2e-47 161.6 0.2 1.5 1 0 0 1 1 1 1 Alpha galactosidase A Melibiase_C PF17801.1 EXF81802.1 - 3.2e-11 43.1 1.5 6.6e-11 42.1 1.5 1.6 1 0 0 1 1 1 1 Alpha galactosidase C-terminal beta sandwich domain Aminotran_4 PF01063.19 EXF81804.1 - 7e-17 62.0 0.0 8.6e-17 61.7 0.0 1.2 1 0 0 1 1 1 1 Amino-transferase class IV DUF3328 PF11807.8 EXF81806.1 - 5.1e-53 180.1 3.5 6.3e-53 179.8 3.5 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) Peptidase_S8 PF00082.22 EXF81807.1 - 3.3e-36 125.1 3.0 5.9e-36 124.2 3.0 1.5 1 0 0 1 1 1 1 Subtilase family fn3_5 PF06280.12 EXF81807.1 - 9.2e-16 58.6 0.0 2.4e-15 57.2 0.0 1.7 2 0 0 2 2 2 1 Fn3-like domain PA PF02225.22 EXF81807.1 - 2.8e-07 30.5 0.0 1e-06 28.6 0.0 2.0 1 1 0 1 1 1 1 PA domain FlgD_ig PF13860.6 EXF81807.1 - 3.2e-05 23.7 0.1 0.00011 22.0 0.1 1.9 1 0 0 1 1 1 1 FlgD Ig-like domain adh_short PF00106.25 EXF81808.1 - 3.3e-42 144.2 0.0 4.2e-42 143.8 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF81808.1 - 1.9e-22 80.0 0.0 2.5e-22 79.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF81808.1 - 3.2e-08 33.7 0.0 4.2e-08 33.3 0.0 1.2 1 0 0 1 1 1 1 KR domain F420_oxidored PF03807.17 EXF81808.1 - 2.7e-05 24.6 0.2 5.6e-05 23.6 0.2 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.20 EXF81808.1 - 3.3e-05 24.0 0.0 6.5e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Polysacc_synt_2 PF02719.15 EXF81808.1 - 0.0012 18.0 0.7 0.0024 17.1 0.8 1.4 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_2 PF03446.15 EXF81808.1 - 0.0073 16.5 0.0 0.02 15.1 0.0 1.7 3 0 0 3 3 3 1 NAD binding domain of 6-phosphogluconate dehydrogenase Sacchrp_dh_NADP PF03435.18 EXF81808.1 - 0.0077 16.5 0.1 0.014 15.7 0.1 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Epimerase PF01370.21 EXF81808.1 - 0.011 15.3 0.0 0.014 14.8 0.0 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family 3HCDH_N PF02737.18 EXF81808.1 - 0.014 15.3 0.3 0.036 14.0 0.1 1.7 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ADH_zinc_N PF00107.26 EXF81808.1 - 0.035 14.1 0.0 0.035 14.1 0.0 1.5 2 0 0 2 2 2 0 Zinc-binding dehydrogenase GDP_Man_Dehyd PF16363.5 EXF81808.1 - 0.067 12.6 0.5 0.11 11.9 0.5 1.4 1 1 0 1 1 1 0 GDP-mannose 4,6 dehydratase p450 PF00067.22 EXF81809.1 - 1.6e-58 198.6 0.0 3.3e-45 154.7 0.0 2.0 2 0 0 2 2 2 2 Cytochrome P450 HAD PF12710.7 EXF81810.1 - 0.00053 20.4 0.0 0.0014 19.1 0.0 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Glyco_hydro_88 PF07470.13 EXF81811.1 - 4.8e-08 32.5 1.5 1e-07 31.4 1.5 1.5 1 0 0 1 1 1 1 Glycosyl Hydrolase Family 88 Fungal_trans PF04082.18 EXF81812.1 - 9.6e-14 51.0 0.0 1.8e-13 50.1 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF81812.1 - 9.9e-08 32.0 12.8 9.9e-08 32.0 12.8 1.7 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF2264 PF10022.9 EXF81813.1 - 4.8e-135 450.2 0.0 6e-135 449.9 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2264) Redoxin PF08534.10 EXF81815.1 - 8.6e-19 67.7 0.0 1.1e-18 67.4 0.0 1.0 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 EXF81815.1 - 1.1e-09 38.2 0.0 1.3e-07 31.5 0.0 2.1 2 0 0 2 2 2 2 AhpC/TSA family p450 PF00067.22 EXF81816.1 - 2.9e-61 207.7 0.0 3.6e-61 207.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Goodbye PF17109.5 EXF81817.1 - 1.6e-13 51.2 0.1 1.6e-13 51.2 0.1 2.6 2 0 0 2 2 2 1 fungal STAND N-terminal Goodbye domain AAA_16 PF13191.6 EXF81817.1 - 3.7e-05 24.2 0.1 0.00012 22.5 0.1 1.9 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EXF81817.1 - 4e-05 23.9 0.0 0.00029 21.1 0.0 2.6 1 1 0 1 1 1 1 AAA domain NACHT PF05729.12 EXF81817.1 - 0.0016 18.4 0.0 0.0042 17.0 0.0 1.7 1 0 0 1 1 1 1 NACHT domain KAP_NTPase PF07693.14 EXF81817.1 - 0.017 14.4 0.5 0.12 11.6 0.0 2.4 2 1 0 3 3 3 0 KAP family P-loop domain DUF2075 PF09848.9 EXF81817.1 - 0.064 12.5 0.7 0.27 10.4 0.0 2.0 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) ATPase PF06745.13 EXF81817.1 - 0.14 11.5 0.7 1.1 8.6 0.0 2.4 2 0 0 2 2 2 0 KaiC AAA_11 PF13086.6 EXF81817.1 - 0.18 11.6 2.9 13 5.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain FYVE PF01363.21 EXF81817.1 - 0.28 11.4 2.3 0.64 10.2 2.3 1.5 1 0 0 1 1 1 0 FYVE zinc finger Acetyltransf_1 PF00583.25 EXF81818.1 - 9.5e-09 35.5 0.0 3.4e-08 33.7 0.0 1.8 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EXF81818.1 - 3.3e-07 30.3 0.0 1.1e-06 28.7 0.0 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EXF81818.1 - 1.9e-06 28.2 0.0 7e-06 26.4 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EXF81818.1 - 0.0002 21.3 0.0 0.00033 20.6 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 EXF81818.1 - 0.0056 16.7 0.1 0.014 15.5 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EXF81818.1 - 0.066 13.4 0.2 0.2 11.8 0.0 1.9 2 0 0 2 2 2 0 GCN5-related N-acetyl-transferase MFS_1 PF07690.16 EXF81819.1 - 5.3e-27 94.7 32.2 5.3e-27 94.7 32.2 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF1772 PF08592.11 EXF81819.1 - 0.003 17.9 9.6 0.12 12.7 0.0 3.2 3 1 0 3 3 3 2 Domain of unknown function (DUF1772) DUF1345 PF07077.11 EXF81819.1 - 0.0096 15.6 0.4 0.036 13.8 0.1 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF1345) Pam17 PF08566.10 EXF81819.1 - 0.47 10.3 7.2 0.68 9.8 0.2 3.0 3 0 0 3 3 3 0 Mitochondrial import protein Pam17 adh_short PF00106.25 EXF81820.1 - 2.5e-41 141.3 7.0 3.1e-41 141.0 7.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF81820.1 - 1.3e-39 136.2 4.6 7.9e-39 133.6 5.3 1.7 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF81820.1 - 3.4e-12 46.6 3.2 4.6e-12 46.2 3.2 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EXF81820.1 - 0.039 13.4 2.1 0.16 11.4 2.1 1.9 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family YAcAr PF10686.9 EXF81820.1 - 0.081 12.9 0.7 0.48 10.4 0.7 2.3 1 1 1 2 2 2 0 YspA, cpYpsA-related SLOG family NIR_SIR_ferr PF03460.17 EXF81820.1 - 0.16 11.8 0.0 16 5.5 0.0 3.0 3 0 0 3 3 3 0 Nitrite/Sulfite reductase ferredoxin-like half domain F420_oxidored PF03807.17 EXF81820.1 - 0.23 12.0 4.1 0.12 13.0 0.8 2.2 3 0 0 3 3 3 0 NADP oxidoreductase coenzyme F420-dependent Sugar_tr PF00083.24 EXF81821.1 - 2.5e-86 290.3 22.8 3.2e-86 290.0 22.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF81821.1 - 9.5e-20 70.8 49.3 2.9e-13 49.5 23.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EXF81821.1 - 0.00012 20.7 3.1 0.00022 19.8 3.1 1.4 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Gly-zipper_YMGG PF13441.6 EXF81821.1 - 0.053 13.3 3.5 0.054 13.2 1.0 2.4 2 0 0 2 2 2 0 YMGG-like Gly-zipper V-ATPase_G_2 PF16999.5 EXF81821.1 - 0.22 11.9 0.2 0.43 11.0 0.1 1.5 2 0 0 2 2 2 0 Vacuolar (H+)-ATPase G subunit adh_short_C2 PF13561.6 EXF81822.1 - 1.1e-52 178.9 0.0 2.3e-52 177.9 0.0 1.4 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF81822.1 - 3.3e-43 147.4 1.1 8.9e-43 146.0 1.1 1.6 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EXF81822.1 - 6.1e-08 32.8 0.1 9.9e-08 32.1 0.1 1.2 1 0 0 1 1 1 1 KR domain Fungal_trans_2 PF11951.8 EXF81823.1 - 2.6e-16 59.4 2.7 7.6e-11 41.4 0.9 2.1 2 0 0 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF81823.1 - 1e-07 31.9 11.5 2.8e-07 30.5 11.5 1.8 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain F_bP_aldolase PF01116.20 EXF81824.1 - 2e-76 257.2 0.1 2.2e-76 257.0 0.1 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II SGL PF08450.12 EXF81825.1 - 6.5e-30 104.5 0.0 1.2e-29 103.6 0.0 1.4 1 1 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Arylesterase PF01731.20 EXF81825.1 - 0.00071 19.7 0.0 0.0019 18.3 0.0 1.7 1 0 0 1 1 1 1 Arylesterase Str_synth PF03088.16 EXF81825.1 - 0.0021 18.2 0.0 0.0054 16.8 0.0 1.7 1 1 0 1 1 1 1 Strictosidine synthase NHL PF01436.21 EXF81825.1 - 0.0059 16.6 2.1 0.65 10.1 0.1 3.5 4 0 0 4 4 4 1 NHL repeat Reg_prop PF07494.11 EXF81825.1 - 0.073 13.3 1.4 3.2 8.3 0.1 3.5 3 0 0 3 3 3 0 Two component regulator propeller OPT PF03169.15 EXF81826.1 - 2.8e-142 475.5 51.7 3.3e-142 475.3 51.7 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein FMN_dh PF01070.18 EXF81827.1 - 3e-85 286.3 0.2 2.5e-49 168.2 0.1 2.0 1 1 1 2 2 2 2 FMN-dependent dehydrogenase IMPDH PF00478.25 EXF81827.1 - 0.00022 20.3 0.6 0.00097 18.2 0.6 1.8 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain NMO PF03060.15 EXF81827.1 - 0.00025 20.6 0.0 0.00037 20.0 0.0 1.3 1 0 0 1 1 1 1 Nitronate monooxygenase Glu_synthase PF01645.17 EXF81827.1 - 0.011 14.9 0.1 0.028 13.6 0.0 1.4 1 1 0 1 1 1 0 Conserved region in glutamate synthase ThiG PF05690.14 EXF81827.1 - 0.017 14.4 0.0 2.6 7.3 0.0 2.3 2 0 0 2 2 2 0 Thiazole biosynthesis protein ThiG DHO_dh PF01180.21 EXF81827.1 - 0.061 12.5 0.8 3.6 6.7 0.0 2.4 3 0 0 3 3 3 0 Dihydroorotate dehydrogenase IGPS PF00218.21 EXF81827.1 - 0.063 12.4 0.0 0.2 10.8 0.0 1.8 1 1 0 1 1 1 0 Indole-3-glycerol phosphate synthase SLAM PF06214.11 EXF81827.1 - 0.12 12.4 0.0 0.22 11.5 0.0 1.4 1 0 0 1 1 1 0 Signaling lymphocytic activation molecule (SLAM) protein adh_short_C2 PF13561.6 EXF81828.1 - 3e-50 171.0 0.3 4e-50 170.6 0.3 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF81828.1 - 4.7e-43 146.9 0.6 6.5e-43 146.5 0.6 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EXF81828.1 - 3.4e-06 27.1 0.1 5.3e-06 26.5 0.1 1.3 1 0 0 1 1 1 1 KR domain DUF1614 PF07758.11 EXF81828.1 - 0.061 13.3 0.0 0.095 12.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1614) Aldo_ket_red PF00248.21 EXF81829.1 - 8.3e-44 149.9 0.0 1.1e-43 149.5 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family FAD_binding_3 PF01494.19 EXF81830.1 - 6.6e-22 78.2 0.0 1.3e-21 77.3 0.0 1.3 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EXF81830.1 - 3.6e-05 23.1 0.0 7.5e-05 22.1 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EXF81830.1 - 7.5e-05 22.9 0.1 0.00018 21.7 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 EXF81830.1 - 0.00032 19.9 0.0 0.0014 17.8 0.0 1.8 2 0 0 2 2 2 1 Glucose inhibited division protein A DAO PF01266.24 EXF81830.1 - 0.00099 18.8 0.1 0.0021 17.7 0.1 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 EXF81830.1 - 0.0014 17.4 0.0 0.0021 16.8 0.0 1.2 1 0 0 1 1 1 1 HI0933-like protein AlaDh_PNT_C PF01262.21 EXF81830.1 - 0.0047 16.3 0.0 0.0073 15.6 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain SE PF08491.10 EXF81830.1 - 0.0047 16.0 0.0 0.0095 15.0 0.0 1.4 1 0 0 1 1 1 1 Squalene epoxidase Pyr_redox PF00070.27 EXF81830.1 - 0.0058 17.2 0.0 0.031 14.9 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 EXF81830.1 - 0.0076 16.1 0.0 0.012 15.4 0.0 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FAD_oxidored PF12831.7 EXF81830.1 - 0.017 14.5 0.3 0.033 13.6 0.3 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EXF81830.1 - 0.082 12.0 0.3 0.27 10.3 0.0 2.0 3 0 0 3 3 3 0 FAD binding domain Peptidase_M24 PF00557.24 EXF81831.1 - 2.7e-48 164.5 0.0 3.2e-48 164.2 0.0 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 zf-C6H2 PF15801.5 EXF81831.1 - 4.5e-21 74.9 7.2 4.5e-21 74.9 7.2 1.8 2 0 0 2 2 2 1 zf-MYND-like zinc finger, mRNA-binding zf-MYND PF01753.18 EXF81831.1 - 0.00014 21.9 2.2 0.00014 21.9 2.2 1.9 2 0 0 2 2 2 1 MYND finger Cornichon PF03311.14 EXF81832.1 - 3.2e-50 169.5 12.5 3.7e-50 169.3 12.5 1.0 1 0 0 1 1 1 1 Cornichon protein WD40 PF00400.32 EXF81833.1 - 8e-32 108.8 9.8 3.1e-06 27.8 0.1 7.1 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EXF81833.1 - 1.3e-14 54.3 0.1 1.1e-05 25.6 0.0 4.1 2 2 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EXF81833.1 - 0.00049 19.2 0.4 1.4 7.8 0.0 3.3 2 1 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 EXF81833.1 - 0.007 16.3 0.3 0.99 9.2 0.0 2.9 2 1 2 4 4 4 1 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 EXF81833.1 - 0.071 11.7 1.0 1.3 7.5 0.0 2.6 1 1 2 3 3 3 0 Nucleoporin Nup120/160 Baculo_p48 PF04878.13 EXF81834.1 - 0.96 8.3 3.0 1.3 7.9 3.0 1.1 1 0 0 1 1 1 0 Baculovirus P48 protein SR-25 PF10500.9 EXF81834.1 - 2.9 7.4 14.1 5.2 6.6 14.1 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein SPX PF03105.19 EXF81834.1 - 4.4 7.1 8.9 4.9 7.0 8.9 1.1 1 0 0 1 1 1 0 SPX domain DUF1664 PF07889.12 EXF81835.1 - 0.12 12.4 3.7 0.27 11.3 3.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Arginase PF00491.21 EXF81836.1 - 4.4e-46 157.6 0.0 5.5e-46 157.3 0.0 1.0 1 0 0 1 1 1 1 Arginase family Fungal_trans PF04082.18 EXF81839.1 - 3.2e-14 52.6 0.2 4.6e-14 52.1 0.2 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF81839.1 - 2.7e-05 24.2 8.3 5.1e-05 23.3 8.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ELYS PF13934.6 EXF81839.1 - 0.12 12.3 0.1 0.28 11.1 0.1 1.5 1 0 0 1 1 1 0 Nuclear pore complex assembly Myb_DNA-binding PF00249.31 EXF81842.1 - 0.00044 20.4 0.1 0.017 15.3 0.1 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain 14-3-3 PF00244.20 EXF81843.1 - 1.4e-08 34.6 0.0 7.1e-08 32.2 0.0 1.8 2 0 0 2 2 2 1 14-3-3 protein Myb_DNA-bind_6 PF13921.6 EXF81844.1 - 3.6e-05 23.9 0.1 0.0001 22.5 0.1 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 EXF81844.1 - 0.00069 19.8 0.3 0.0015 18.7 0.3 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain DUF4202 PF13875.6 EXF81845.1 - 3.5e-76 255.3 0.3 3.9e-76 255.1 0.3 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4202) FMN_dh PF01070.18 EXF81846.1 - 9.1e-113 376.8 0.0 1.1e-112 376.5 0.0 1.1 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.28 EXF81846.1 - 8.8e-19 67.4 0.0 1.6e-18 66.6 0.0 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain IMPDH PF00478.25 EXF81846.1 - 0.00011 21.3 0.7 0.00092 18.3 0.3 2.4 1 1 1 2 2 2 1 IMP dehydrogenase / GMP reductase domain Glu_synthase PF01645.17 EXF81846.1 - 0.0007 18.8 0.0 0.0012 18.0 0.0 1.4 1 0 0 1 1 1 1 Conserved region in glutamate synthase NMO PF03060.15 EXF81846.1 - 0.0008 18.9 0.2 0.0015 18.0 0.1 1.4 1 1 0 1 1 1 1 Nitronate monooxygenase RCR PF12273.8 EXF81847.1 - 0.0023 18.6 12.7 0.0023 18.6 12.7 2.4 2 0 0 2 2 2 1 Chitin synthesis regulation, resistance to Congo red Syndecan PF01034.20 EXF81847.1 - 0.0026 17.6 0.0 0.0068 16.3 0.0 1.6 1 0 0 1 1 1 1 Syndecan domain Alpha_GJ PF03229.13 EXF81847.1 - 0.017 15.7 4.3 0.017 15.7 4.3 2.2 2 0 0 2 2 2 0 Alphavirus glycoprotein J Podoplanin PF05808.11 EXF81847.1 - 0.046 13.8 2.3 0.1 12.7 2.3 1.5 1 0 0 1 1 1 0 Podoplanin TMEM154 PF15102.6 EXF81847.1 - 0.15 11.9 0.0 0.42 10.5 0.0 1.7 1 0 0 1 1 1 0 TMEM154 protein family SKG6 PF08693.10 EXF81847.1 - 0.17 11.3 4.2 0.33 10.4 4.2 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain EphA2_TM PF14575.6 EXF81847.1 - 0.2 12.6 1.3 0.86 10.5 0.0 2.4 2 1 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Spb1_C PF07780.12 EXF81849.1 - 5.3e-78 261.5 48.3 5.3e-78 261.5 48.3 4.1 2 1 1 3 3 3 1 Spb1 C-terminal domain FtsJ PF01728.19 EXF81849.1 - 5.2e-57 192.8 0.0 8.7e-57 192.1 0.0 1.4 1 0 0 1 1 1 1 FtsJ-like methyltransferase DUF3381 PF11861.8 EXF81849.1 - 4e-52 176.3 15.0 4e-52 176.3 15.0 4.9 3 1 1 4 4 4 1 Domain of unknown function (DUF3381) Methyltransf_23 PF13489.6 EXF81849.1 - 0.0025 17.7 0.1 0.013 15.4 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain WD40 PF00400.32 EXF81850.1 - 1.1e-13 51.4 1.3 0.033 15.0 0.0 6.6 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EXF81850.1 - 4.7e-05 23.6 0.0 0.65 10.3 0.0 4.2 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EXF81850.1 - 0.18 10.7 0.1 1.5 7.7 0.0 2.5 4 0 0 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Heme_oxygenase PF01126.20 EXF81851.1 - 2.4e-07 30.7 0.0 1.4e-06 28.2 0.0 1.9 2 0 0 2 2 2 1 Heme oxygenase Peptidase_M3_N PF08439.10 EXF81851.1 - 0.25 11.6 1.9 2.8 8.3 0.0 3.0 3 0 0 3 3 3 0 Oligopeptidase F EamA PF00892.20 EXF81852.1 - 2.9e-11 43.7 36.1 3.1e-05 24.2 4.4 3.1 3 0 0 3 3 3 3 EamA-like transporter family DUF3955 PF13127.6 EXF81852.1 - 4.6e-09 36.0 1.6 4.6e-09 36.0 1.6 3.1 3 0 0 3 3 3 1 Protein of unknown function (DUF3955) PUNUT PF16913.5 EXF81852.1 - 1.6e-07 30.9 3.4 1.6e-07 30.9 3.4 2.3 2 1 0 3 3 3 1 Purine nucleobase transmembrane transport SLC35F PF06027.12 EXF81852.1 - 7.6e-05 22.4 13.8 7.6e-05 22.4 13.8 1.9 2 0 0 2 2 2 1 Solute carrier family 35 UAA PF08449.11 EXF81852.1 - 0.00078 18.7 12.5 0.00078 18.7 12.5 1.5 2 0 0 2 2 2 1 UAA transporter family Brr6_like_C_C PF10104.9 EXF81852.1 - 0.56 10.0 0.0 0.56 10.0 0.0 3.0 3 0 0 3 3 3 0 Di-sulfide bridge nucleocytoplasmic transport domain Ras PF00071.22 EXF81853.1 - 3.9e-57 192.4 0.1 4.6e-57 192.1 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EXF81853.1 - 4.6e-32 110.7 0.0 6.6e-32 110.2 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EXF81853.1 - 3.2e-13 49.5 0.0 3.8e-13 49.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EXF81853.1 - 5e-08 33.0 0.0 8.2e-08 32.3 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EXF81853.1 - 2.8e-06 26.9 0.0 3.4e-06 26.6 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EXF81853.1 - 4.2e-05 23.2 0.0 0.0018 17.9 0.0 2.2 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EXF81853.1 - 9.3e-05 22.4 0.1 0.0037 17.2 0.1 2.4 1 1 2 3 3 3 1 RsgA GTPase SRPRB PF09439.10 EXF81853.1 - 0.0024 17.3 0.0 0.003 17.0 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_5 PF07728.14 EXF81853.1 - 0.0038 17.2 0.0 0.0066 16.4 0.0 1.6 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) PduV-EutP PF10662.9 EXF81853.1 - 0.0058 16.4 0.1 0.13 12.0 0.0 2.2 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AAA_16 PF13191.6 EXF81853.1 - 0.0085 16.5 0.0 0.014 15.8 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EXF81853.1 - 0.0095 16.2 0.0 0.016 15.5 0.0 1.5 1 1 0 1 1 1 1 AAA domain ATP_bind_1 PF03029.17 EXF81853.1 - 0.012 15.5 0.2 0.33 10.7 0.0 2.1 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein AAA_24 PF13479.6 EXF81853.1 - 0.02 14.7 0.0 0.042 13.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain Septin PF00735.18 EXF81853.1 - 0.02 14.2 0.1 0.048 12.9 0.0 1.7 2 0 0 2 2 2 0 Septin NB-ARC PF00931.22 EXF81853.1 - 0.021 14.0 0.1 0.29 10.3 0.0 2.0 2 0 0 2 2 2 0 NB-ARC domain AAA_7 PF12775.7 EXF81853.1 - 0.024 14.1 0.1 0.041 13.4 0.1 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region cobW PF02492.19 EXF81853.1 - 0.038 13.6 0.0 0.1 12.2 0.0 1.7 1 1 1 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain ATPase_2 PF01637.18 EXF81853.1 - 0.059 13.3 0.2 0.13 12.1 0.0 1.6 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea NTPase_1 PF03266.15 EXF81853.1 - 0.096 12.6 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 NTPase TniB PF05621.11 EXF81853.1 - 0.12 11.8 0.0 0.19 11.1 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein NACHT PF05729.12 EXF81853.1 - 0.12 12.2 0.0 0.19 11.6 0.0 1.3 1 0 0 1 1 1 0 NACHT domain RNA_helicase PF00910.22 EXF81853.1 - 0.14 12.5 0.0 0.52 10.7 0.0 1.9 2 0 0 2 2 2 0 RNA helicase AAA_lid_2 PF17863.1 EXF81854.1 - 4e-06 26.6 0.3 9.3e-06 25.4 0.3 1.7 1 0 0 1 1 1 1 AAA lid domain AAA_3 PF07726.11 EXF81854.1 - 0.0052 16.6 0.0 0.011 15.6 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) GDA1_CD39 PF01150.17 EXF81855.1 - 1.3e-104 350.3 0.0 1.6e-104 349.9 0.0 1.0 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family Ppx-GppA PF02541.16 EXF81855.1 - 0.021 14.3 0.0 0.037 13.5 0.0 1.3 1 0 0 1 1 1 0 Ppx/GppA phosphatase family PUL PF08324.11 EXF81856.1 - 9.4e-64 215.3 0.1 1.3e-63 214.8 0.1 1.2 1 0 0 1 1 1 1 PUL domain Peptidase_C97 PF05903.14 EXF81856.1 - 1.1e-34 119.4 0.0 1.8e-34 118.8 0.0 1.3 1 0 0 1 1 1 1 PPPDE putative peptidase domain Thioredoxin PF00085.20 EXF81856.1 - 5.4e-11 42.4 0.0 1e-10 41.5 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin TraF PF13728.6 EXF81856.1 - 0.00025 20.9 0.0 0.00053 19.9 0.0 1.5 1 0 0 1 1 1 1 F plasmid transfer operon protein Redoxin PF08534.10 EXF81856.1 - 0.009 15.7 0.0 0.017 14.8 0.0 1.4 1 0 0 1 1 1 1 Redoxin Glutaredoxin PF00462.24 EXF81856.1 - 0.032 14.5 0.0 0.086 13.1 0.0 1.8 1 0 0 1 1 1 0 Glutaredoxin Thioredoxin_9 PF14595.6 EXF81856.1 - 0.15 11.8 0.0 0.28 10.9 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin Kinesin PF00225.23 EXF81857.1 - 4.5e-113 377.5 0.1 7.6e-113 376.8 0.1 1.3 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EXF81857.1 - 7.7e-24 84.3 0.0 1.8e-23 83.2 0.0 1.6 1 0 0 1 1 1 1 Microtubule binding DUF1087 PF06465.13 EXF81857.1 - 0.00022 21.2 0.1 0.0011 18.9 0.1 2.4 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1087) YabA PF06156.13 EXF81857.1 - 0.05 14.2 8.1 4.3 8.0 0.1 3.7 3 1 0 3 3 3 0 Initiation control protein YabA IL11 PF07400.11 EXF81857.1 - 0.074 12.7 0.2 0.17 11.5 0.2 1.6 1 0 0 1 1 1 0 Interleukin 11 Noggin PF05806.12 EXF81857.1 - 0.3 11.0 0.7 16 5.3 0.3 2.6 2 0 0 2 2 2 0 Noggin PriC PF07445.12 EXF81857.1 - 0.51 10.3 11.6 0.86 9.5 10.6 1.8 1 1 0 1 1 1 0 Primosomal replication protein priC DUF87 PF01935.17 EXF81857.1 - 0.68 10.0 0.0 0.68 10.0 0.0 3.1 3 1 0 3 3 3 0 Helicase HerA, central domain V_ATPase_I PF01496.19 EXF81857.1 - 6.4 4.6 6.4 12 3.6 6.4 1.4 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family IF4E PF01652.18 EXF81858.1 - 2.9e-38 131.2 0.5 3.7e-38 130.8 0.5 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E Lactamase_B PF00753.27 EXF81859.1 - 3.3e-18 66.4 1.2 2.2e-10 40.9 0.1 2.7 3 0 0 3 3 3 2 Metallo-beta-lactamase superfamily HAGH_C PF16123.5 EXF81859.1 - 1.7e-14 54.1 0.4 3.1e-14 53.2 0.4 1.5 1 0 0 1 1 1 1 Hydroxyacylglutathione hydrolase C-terminus Lactamase_B_2 PF12706.7 EXF81859.1 - 0.0011 18.5 0.3 0.01 15.4 0.3 2.2 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Peripla_BP_4 PF13407.6 EXF81859.1 - 0.025 14.2 0.2 0.3 10.6 0.0 2.1 2 0 0 2 2 2 0 Periplasmic binding protein domain Las1 PF04031.13 EXF81860.1 - 5.5e-64 214.9 0.8 7.7e-64 214.4 0.8 1.2 1 0 0 1 1 1 1 Las1-like DUF5525 PF17663.1 EXF81860.1 - 1.5 6.8 22.4 2.3 6.2 22.4 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5525) Sacchrp_dh_C PF16653.5 EXF81861.1 - 5e-95 318.6 0.0 9.6e-95 317.7 0.0 1.5 2 0 0 2 2 2 1 Saccharopine dehydrogenase C-terminal domain Sacchrp_dh_NADP PF03435.18 EXF81861.1 - 2.5e-25 89.2 0.2 4.3e-25 88.5 0.2 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_10 PF13460.6 EXF81861.1 - 1.8e-05 24.7 0.1 5.8e-05 23.1 0.1 1.9 2 0 0 2 2 2 1 NAD(P)H-binding Shikimate_DH PF01488.20 EXF81861.1 - 3.4e-05 23.9 0.0 6.9e-05 22.9 0.0 1.6 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase IlvN PF07991.12 EXF81861.1 - 0.0066 16.0 0.2 0.046 13.3 0.0 2.4 2 1 0 3 3 3 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain GFO_IDH_MocA PF01408.22 EXF81861.1 - 0.082 13.7 0.3 0.33 11.8 0.1 2.0 2 0 0 2 2 2 0 Oxidoreductase family, NAD-binding Rossmann fold NAD_binding_3 PF03447.16 EXF81861.1 - 0.1 13.3 0.1 0.24 12.1 0.1 1.7 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain SieB PF14163.6 EXF81861.1 - 0.18 11.3 0.0 3.2 7.2 0.0 2.2 2 0 0 2 2 2 0 Super-infection exclusion protein B EB PF01683.18 EXF81863.1 - 0.48 10.7 5.4 0.16 12.3 1.9 1.9 2 0 0 2 2 2 0 EB module WSC PF01822.19 EXF81865.1 - 3.9e-70 232.1 78.9 6.5e-19 67.9 11.1 5.3 5 0 0 5 5 5 4 WSC domain peroxidase PF00141.23 EXF81865.1 - 2.8e-22 79.5 0.1 5.9e-22 78.5 0.1 1.5 1 0 0 1 1 1 1 Peroxidase MARVEL PF01284.23 EXF81866.1 - 0.00042 20.4 17.7 0.011 15.7 18.1 2.1 1 1 0 1 1 1 1 Membrane-associating domain DUF3422 PF11902.8 EXF81866.1 - 0.046 12.8 1.0 5.3 6.1 1.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3422) DUF3402 PF11882.8 EXF81867.1 - 1.3e-214 713.6 0.0 1.7e-214 713.2 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3402) N1221 PF07923.13 EXF81867.1 - 8.9e-90 300.8 0.2 1.5e-89 300.1 0.2 1.4 1 0 0 1 1 1 1 N1221-like protein NAD_kinase PF01513.21 EXF81868.1 - 6.2e-73 245.5 0.0 1.1e-72 244.7 0.0 1.3 1 0 0 1 1 1 1 ATP-NAD kinase DUF4813 PF16072.5 EXF81869.1 - 0.14 11.8 35.6 0.025 14.2 10.9 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4813) Med21 PF11221.8 EXF81869.1 - 3.3 8.0 6.0 0.78 10.0 1.7 1.9 2 0 0 2 2 2 0 Subunit 21 of Mediator complex Abhydrolase_4 PF08386.10 EXF81871.1 - 3.6e-17 62.4 0.0 1e-16 60.9 0.0 1.7 2 0 0 2 2 2 1 TAP-like protein Abhydrolase_1 PF00561.20 EXF81871.1 - 3.7e-16 59.5 0.1 4.4e-07 29.8 0.0 3.1 3 0 0 3 3 3 3 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EXF81871.1 - 0.17 11.1 0.1 0.63 9.3 0.0 1.9 3 0 0 3 3 3 0 Serine aminopeptidase, S33 Grg1 PF11034.8 EXF81872.1 - 2.5e-31 107.7 11.5 2.9e-31 107.5 11.5 1.0 1 0 0 1 1 1 1 Glucose-repressible protein Grg1 Phe_tRNA-synt_N PF02912.18 EXF81872.1 - 0.047 13.6 0.2 0.08 12.9 0.1 1.5 1 1 1 2 2 2 0 Aminoacyl tRNA synthetase class II, N-terminal domain DUF3756 PF12581.8 EXF81872.1 - 0.076 12.9 0.3 0.12 12.3 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3756) EBP PF05241.12 EXF81873.1 - 2.2e-73 245.5 8.5 2.5e-73 245.3 8.5 1.0 1 0 0 1 1 1 1 Emopamil binding protein TMEM208_SND2 PF05620.11 EXF81873.1 - 0.48 10.2 10.8 0.28 11.0 2.4 2.3 2 0 0 2 2 2 0 SRP-independent targeting protein 2/TMEM208 Aldo_ket_red PF00248.21 EXF81874.1 - 0.19 10.9 0.0 0.82 8.8 0.0 1.8 1 1 1 2 2 2 0 Aldo/keto reductase family PAP2 PF01569.21 EXF81876.1 - 6.3e-13 48.7 5.1 6.3e-13 48.7 5.1 2.3 1 1 1 2 2 2 1 PAP2 superfamily UbiA PF01040.18 EXF81876.1 - 0.0002 20.7 1.6 0.0002 20.7 1.6 1.9 2 0 0 2 2 2 1 UbiA prenyltransferase family DUF212 PF02681.14 EXF81876.1 - 0.021 15.0 0.1 0.57 10.3 0.0 2.3 1 1 1 2 2 2 0 Divergent PAP2 family DUF1345 PF07077.11 EXF81876.1 - 0.2 11.3 4.3 0.18 11.5 2.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1345) IBR PF01485.21 EXF81877.1 - 1e-19 70.5 38.3 2.1e-15 56.7 4.0 4.5 4 1 1 5 5 5 3 IBR domain, a half RING-finger domain RWD PF05773.22 EXF81877.1 - 1.5e-15 57.5 0.0 3e-15 56.5 0.0 1.5 1 0 0 1 1 1 1 RWD domain zf-RING_2 PF13639.6 EXF81877.1 - 0.0004 20.6 7.6 0.0004 20.6 7.6 4.1 3 1 1 4 4 4 2 Ring finger domain zf-RING_UBOX PF13445.6 EXF81877.1 - 0.00053 19.9 5.9 0.00053 19.9 5.9 3.7 3 0 0 3 3 3 2 RING-type zinc-finger zf-C3HC4 PF00097.25 EXF81877.1 - 0.0093 15.8 8.4 0.0093 15.8 8.4 4.3 3 1 1 4 4 4 2 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EXF81877.1 - 0.012 15.4 7.4 0.044 13.5 7.4 2.1 1 0 0 1 1 1 0 RING-like zinc finger zf-RING_5 PF14634.6 EXF81877.1 - 0.014 15.4 8.0 0.014 15.4 8.0 4.1 3 1 0 3 3 3 0 zinc-RING finger domain FYVE PF01363.21 EXF81877.1 - 8.1 6.7 25.4 2.4 8.3 4.1 3.5 3 0 0 3 3 3 0 FYVE zinc finger MFS_1 PF07690.16 EXF81878.1 - 4.5e-21 75.2 38.2 4.7e-21 75.1 37.5 1.3 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF3487 PF11990.8 EXF81878.1 - 3.2 7.7 5.0 15 5.5 0.6 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3487) Mucin PF01456.17 EXF81878.1 - 7.4 6.6 18.5 15 5.6 18.5 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein Glyco_hydro_72 PF03198.14 EXF81879.1 - 2.5e-118 394.9 6.2 3.4e-118 394.5 6.2 1.1 1 0 0 1 1 1 1 Glucanosyltransferase X8 PF07983.13 EXF81879.1 - 2.3e-22 79.5 4.1 7e-22 77.9 4.1 1.9 1 0 0 1 1 1 1 X8 domain BIR PF00653.21 EXF81880.1 - 6.6e-10 39.5 0.1 9.7e-10 39.0 0.1 1.3 1 0 0 1 1 1 1 Inhibitor of Apoptosis domain RITA PF17066.5 EXF81880.1 - 0.019 14.6 0.2 0.024 14.3 0.2 1.1 1 0 0 1 1 1 0 RBPJ-interacting and tubulin associated protein Mac PF12464.8 EXF81882.1 - 5.7e-14 52.1 0.0 8.8e-14 51.5 0.0 1.3 1 0 0 1 1 1 1 Maltose acetyltransferase Hexapep PF00132.24 EXF81882.1 - 1.3e-12 46.9 11.8 1.1e-10 40.8 3.6 3.6 2 1 0 2 2 2 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 EXF81882.1 - 9.7e-10 38.0 4.1 9.7e-10 38.0 4.1 3.2 4 0 0 4 4 4 1 Hexapeptide repeat of succinyl-transferase DUF2306 PF10067.9 EXF81883.1 - 5.4e-33 114.3 8.8 7.8e-33 113.8 8.8 1.2 1 0 0 1 1 1 1 Predicted membrane protein (DUF2306) CitMHS PF03600.16 EXF81883.1 - 0.31 10.2 7.0 0.42 9.8 7.0 1.2 1 0 0 1 1 1 0 Citrate transporter Cerato-platanin PF07249.12 EXF81884.1 - 0.00012 22.2 0.5 0.00025 21.1 0.0 1.8 2 0 0 2 2 2 1 Cerato-platanin Amidase PF01425.21 EXF81885.1 - 8e-57 193.2 0.0 9.2e-48 163.3 0.1 2.1 2 0 0 2 2 2 2 Amidase Pyr_redox_3 PF13738.6 EXF81886.1 - 1.2e-25 90.4 0.1 1.9e-23 83.2 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EXF81886.1 - 1.9e-18 66.7 0.0 5.1e-14 52.2 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 EXF81886.1 - 3.4e-17 62.1 0.1 6.6e-16 57.8 0.1 2.1 1 1 0 1 1 1 1 Flavin-binding monooxygenase-like K_oxygenase PF13434.6 EXF81886.1 - 1.6e-15 57.1 0.3 2.4e-13 50.0 0.1 2.5 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) FAD_binding_3 PF01494.19 EXF81886.1 - 1.2e-09 37.9 0.7 1.1e-05 24.9 0.0 2.5 2 1 0 2 2 2 2 FAD binding domain Pyr_redox PF00070.27 EXF81886.1 - 4.7e-06 27.1 0.1 0.58 10.7 0.0 3.6 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EXF81886.1 - 8e-06 25.7 0.7 8.2e-05 22.3 0.2 2.5 2 1 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EXF81886.1 - 9.9e-05 22.4 1.3 0.66 9.9 0.7 3.0 2 1 0 2 2 2 2 FAD-NAD(P)-binding FAD_binding_2 PF00890.24 EXF81886.1 - 0.0006 19.0 0.3 0.13 11.3 0.0 2.3 2 0 0 2 2 2 2 FAD binding domain Amino_oxidase PF01593.24 EXF81886.1 - 0.00067 19.1 0.1 0.078 12.3 0.0 3.0 3 0 0 3 3 3 1 Flavin containing amine oxidoreductase HI0933_like PF03486.14 EXF81886.1 - 0.002 16.9 0.3 0.43 9.2 0.1 2.7 3 0 0 3 3 3 2 HI0933-like protein Lycopene_cycl PF05834.12 EXF81886.1 - 0.0033 16.6 0.4 0.065 12.3 0.1 2.9 2 1 1 3 3 3 1 Lycopene cyclase protein Shikimate_DH PF01488.20 EXF81886.1 - 0.012 15.6 0.1 1.9 8.5 0.0 3.1 3 0 0 3 3 3 0 Shikimate / quinate 5-dehydrogenase GIDA PF01134.22 EXF81886.1 - 0.024 13.8 1.2 8.9 5.3 0.0 3.1 3 0 0 3 3 3 0 Glucose inhibited division protein A ApbA PF02558.16 EXF81886.1 - 0.087 12.5 0.0 0.42 10.2 0.0 2.2 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA NAD_binding_8 PF13450.6 EXF81886.1 - 0.1 12.9 0.0 0.26 11.5 0.0 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain TPR_2 PF07719.17 EXF81887.1 - 1.5e-10 40.4 6.5 2.9e-06 27.0 0.3 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 EXF81887.1 - 4.7e-08 32.5 3.4 0.0028 17.4 0.1 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 EXF81887.1 - 1.1e-06 28.4 0.9 0.00031 20.7 0.1 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 EXF81887.1 - 9.6e-05 23.0 2.9 0.0059 17.2 1.6 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 EXF81887.1 - 0.00013 22.2 4.2 0.018 15.3 0.0 3.4 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 EXF81887.1 - 0.00038 20.9 0.4 0.005 17.3 0.1 2.7 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 EXF81887.1 - 0.07 14.0 4.7 0.55 11.2 0.4 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.6 EXF81887.1 - 0.082 12.6 1.8 6.8 6.5 0.0 3.2 3 1 0 3 3 3 0 TPR repeat TPR_10 PF13374.6 EXF81887.1 - 0.34 10.8 2.8 5.8 6.9 0.1 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_4 PF07721.14 EXF81887.1 - 0.64 10.8 5.7 4.5 8.2 0.4 3.2 2 1 0 2 2 2 0 Tetratricopeptide repeat CAML PF14963.6 EXF81888.1 - 0.03 14.4 0.4 0.033 14.3 0.4 1.0 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand UQ_con PF00179.26 EXF81889.1 - 6.2e-26 90.7 0.0 1.6e-25 89.4 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme IBR PF01485.21 EXF81889.1 - 0.028 14.6 0.7 0.028 14.6 0.7 1.9 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain Glyco_hydro_6 PF01341.17 EXF81890.1 - 3.6e-108 361.9 0.8 4.9e-108 361.5 0.8 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 6 CBM_1 PF00734.18 EXF81890.1 - 3.9e-12 45.9 11.2 3.9e-12 45.9 11.2 2.5 2 0 0 2 2 2 1 Fungal cellulose binding domain MGC-24 PF05283.11 EXF81890.1 - 1.2 9.5 10.4 3.4 8.1 10.4 1.7 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin Yeast-kill-tox PF09207.11 EXF81890.1 - 1.4 9.6 10.2 0.27 11.9 3.6 2.9 3 0 0 3 3 3 0 Yeast killer toxin E_Pc_C PF06752.12 EXF81890.1 - 4.9 7.2 11.2 9.3 6.3 11.2 1.4 1 0 0 1 1 1 0 Enhancer of Polycomb C-terminus Adap_comp_sub PF00928.21 EXF81893.1 - 4.6e-83 278.6 0.0 5.7e-83 278.3 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 EXF81893.1 - 8.3e-05 22.5 0.2 0.00015 21.7 0.2 1.4 1 0 0 1 1 1 1 Clathrin adaptor complex small chain RIBIOP_C PF04950.12 EXF81893.1 - 0.068 12.6 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal muHD PF10291.9 EXF81893.1 - 0.069 12.6 0.1 0.14 11.5 0.1 1.5 1 0 0 1 1 1 0 Muniscin C-terminal mu homology domain Cu-oxidase_3 PF07732.15 EXF81895.1 - 1.1e-38 131.9 4.0 2.2e-38 130.9 4.0 1.6 1 0 0 1 1 1 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 EXF81895.1 - 6.3e-36 123.1 10.0 2.1e-35 121.4 0.5 3.2 2 1 0 2 2 2 1 Multicopper oxidase Cu-oxidase PF00394.22 EXF81895.1 - 1.2e-21 77.5 2.1 3.6e-21 76.0 0.1 2.7 3 1 0 3 3 3 1 Multicopper oxidase E1-E2_ATPase PF00122.20 EXF81897.1 - 1e-42 145.7 4.6 1e-42 145.7 4.6 1.9 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 EXF81897.1 - 1.5e-19 71.1 0.0 2.7e-19 70.3 0.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HMA PF00403.26 EXF81897.1 - 4.8e-06 26.9 0.2 4.8e-06 26.9 0.2 2.6 3 0 0 3 3 3 1 Heavy-metal-associated domain Hydrolase_3 PF08282.12 EXF81897.1 - 0.00036 20.4 0.0 0.0014 18.5 0.0 1.9 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Zn_clus PF00172.18 EXF81898.1 - 0.0023 18.0 3.6 0.0055 16.8 3.6 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain AA_permease PF00324.21 EXF81899.1 - 2e-129 432.3 33.8 2.5e-129 432.0 33.8 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EXF81899.1 - 7.3e-42 143.7 38.3 9.2e-42 143.3 38.3 1.1 1 0 0 1 1 1 1 Amino acid permease Nucleos_tra2_C PF07662.13 EXF81900.1 - 6.5e-73 245.0 1.8 6.5e-73 245.0 1.8 2.7 3 1 0 3 3 3 1 Na+ dependent nucleoside transporter C-terminus Nucleos_tra2_N PF01773.20 EXF81900.1 - 9.7e-22 77.4 2.4 9.7e-22 77.4 2.4 3.3 4 1 1 5 5 5 1 Na+ dependent nucleoside transporter N-terminus ATP1G1_PLM_MAT8 PF02038.16 EXF81900.1 - 0.091 12.2 5.4 0.47 9.9 2.1 2.8 2 0 0 2 2 2 0 ATP1G1/PLM/MAT8 family Gate PF07670.14 EXF81900.1 - 2.2 8.6 20.5 0.63 10.3 7.6 3.8 3 0 0 3 3 3 0 Nucleoside recognition Amidase PF01425.21 EXF81901.1 - 6.9e-73 246.1 0.0 4.6e-72 243.4 0.0 1.9 1 1 0 1 1 1 1 Amidase DUF3381 PF11861.8 EXF81902.1 - 0.017 14.9 7.0 0.022 14.6 7.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) Pox_H7 PF04787.12 EXF81902.1 - 0.54 10.8 2.7 0.77 10.3 2.7 1.1 1 0 0 1 1 1 0 Late protein H7 DUF4366 PF14283.6 EXF81902.1 - 1.2 9.2 7.1 0.14 12.2 1.5 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4366) Polyketide_cyc2 PF10604.9 EXF81904.1 - 6e-08 33.1 0.1 6.6e-08 32.9 0.1 1.1 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc PF03364.20 EXF81904.1 - 0.0013 19.0 0.0 0.002 18.3 0.0 1.6 1 1 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport DUF1857 PF08982.11 EXF81904.1 - 0.014 15.3 0.1 0.059 13.2 0.1 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF1857) MFS_1 PF07690.16 EXF81906.1 - 1.2e-46 159.3 26.3 4.3e-44 150.9 12.3 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF81906.1 - 5.1e-13 48.7 1.5 5.1e-13 48.7 1.5 2.9 3 0 0 3 3 3 2 Sugar (and other) transporter MFS_3 PF05977.13 EXF81906.1 - 0.0018 16.8 1.2 0.0018 16.8 1.2 2.4 2 1 0 2 2 2 1 Transmembrane secretion effector OATP PF03137.20 EXF81906.1 - 0.35 9.1 8.1 0.34 9.1 0.2 3.2 2 1 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family MFS_1_like PF12832.7 EXF81906.1 - 1.9 7.3 12.9 0.18 10.6 2.0 2.9 2 1 1 3 3 3 0 MFS_1 like family DUF4536 PF15055.6 EXF81907.1 - 0.0055 16.9 0.1 0.014 15.6 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4536) LIDHydrolase PF10230.9 EXF81908.1 - 1.1e-56 192.4 0.0 1.7e-56 191.7 0.0 1.3 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase MFS_1 PF07690.16 EXF81908.1 - 1.8e-24 86.3 36.9 3.1e-24 85.6 36.6 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily Abhydrolase_6 PF12697.7 EXF81908.1 - 0.0047 17.6 1.3 0.007 17.0 0.2 1.9 2 1 0 2 2 2 1 Alpha/beta hydrolase family Phage_holin_2_4 PF16082.5 EXF81908.1 - 1.4 8.7 0.0 1.4 8.7 0.0 2.9 3 1 1 4 4 4 0 Bacteriophage holin family, superfamily II-like MFS_1 PF07690.16 EXF81909.1 - 7.1e-26 91.0 49.4 8.2e-16 57.9 21.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Syndecan PF01034.20 EXF81909.1 - 0.019 14.9 0.1 0.074 13.0 0.1 2.0 1 0 0 1 1 1 0 Syndecan domain Pec_lyase_C PF00544.19 EXF81910.1 - 1.2e-45 155.6 4.5 2e-45 155.0 4.5 1.3 1 0 0 1 1 1 1 Pectate lyase Beta_helix PF13229.6 EXF81910.1 - 0.0003 20.7 7.7 0.018 14.9 7.7 2.4 1 1 0 1 1 1 1 Right handed beta helix region Abhydrolase_1 PF00561.20 EXF81911.1 - 1.9e-10 40.8 0.0 3.6e-10 39.9 0.0 1.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EXF81911.1 - 4.3e-05 22.9 0.0 0.00097 18.5 0.0 2.1 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EXF81911.1 - 0.072 13.7 0.0 0.096 13.3 0.0 1.5 1 1 0 1 1 1 0 Alpha/beta hydrolase family RPE65 PF03055.15 EXF81912.1 - 3.8e-96 323.1 0.0 4.4e-96 322.9 0.0 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein Abhydrolase_3 PF07859.13 EXF81913.1 - 4.1e-19 69.3 0.0 1.5e-17 64.1 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EXF81913.1 - 2.8e-08 33.5 0.0 3.9e-05 23.2 0.0 2.8 3 0 0 3 3 3 2 Prolyl oligopeptidase family COesterase PF00135.28 EXF81913.1 - 0.00015 20.8 0.1 0.00071 18.6 0.0 1.9 2 0 0 2 2 2 1 Carboxylesterase family Hydrolase_4 PF12146.8 EXF81913.1 - 0.00039 19.8 0.0 0.0017 17.7 0.0 1.9 2 1 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EXF81913.1 - 0.0006 20.5 1.0 0.00083 20.0 1.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family DLH PF01738.18 EXF81913.1 - 0.018 14.6 0.0 1 8.8 0.0 2.2 2 0 0 2 2 2 0 Dienelactone hydrolase family Abhydrolase_2 PF02230.16 EXF81913.1 - 0.021 14.7 0.0 2.7 7.7 0.0 2.1 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Y1_Tnp PF01797.16 EXF81914.1 - 0.088 12.9 0.2 1.9 8.6 0.0 2.1 1 1 1 2 2 2 0 Transposase IS200 like p450 PF00067.22 EXF81915.1 - 1.6e-34 119.5 0.1 1.6e-22 79.9 0.0 2.0 1 1 1 2 2 2 2 Cytochrome P450 DUF1993 PF09351.10 EXF81917.1 - 7.9e-54 182.1 0.1 9.2e-54 181.9 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1993) TBCA PF02970.16 EXF81917.1 - 0.093 13.1 0.1 0.16 12.3 0.1 1.4 1 0 0 1 1 1 0 Tubulin binding cofactor A FMO-like PF00743.19 EXF81918.1 - 2.5e-05 22.9 0.3 0.00046 18.7 0.1 2.5 2 1 0 2 2 2 1 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 EXF81918.1 - 3.6e-05 23.1 0.0 0.099 11.9 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EXF81918.1 - 7.2e-05 22.1 0.4 0.00095 18.4 0.2 2.1 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.6 EXF81918.1 - 0.00037 19.9 0.0 0.0097 15.2 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 EXF81918.1 - 0.0076 15.6 0.1 0.69 9.1 0.0 3.0 3 1 0 4 4 4 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EXF81918.1 - 0.0094 16.2 0.0 0.03 14.5 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Sas6_CC PF18594.1 EXF81918.1 - 0.1 12.4 0.0 0.21 11.4 0.0 1.4 1 0 0 1 1 1 0 Sas6/XLF/XRCC4 coiled-coil domain Methyltransf_2 PF00891.18 EXF81919.1 - 2.1e-20 72.9 0.0 3.3e-20 72.3 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain HsbA PF12296.8 EXF81920.1 - 9.4e-31 106.7 17.0 9.4e-31 106.7 17.0 2.2 2 0 0 2 2 2 1 Hydrophobic surface binding protein A AAA_12 PF13087.6 EXF81921.1 - 7.2e-40 136.7 0.0 1.8e-39 135.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 EXF81921.1 - 1.2e-36 126.1 0.0 2.1e-13 50.8 0.0 5.5 5 0 0 5 5 5 3 ATPase family associated with various cellular activities (AAA) AAA_11 PF13086.6 EXF81921.1 - 1.5e-32 113.5 22.0 1.8e-28 100.0 0.0 5.4 5 0 0 5 5 5 2 AAA domain AAA_30 PF13604.6 EXF81921.1 - 1.2e-18 67.5 0.8 3.7e-05 23.5 0.0 5.1 5 0 0 5 5 5 4 AAA domain AAA_lid_6 PF17866.1 EXF81921.1 - 1.4e-17 63.6 5.1 4e-10 39.7 0.9 3.5 2 0 0 2 2 2 2 AAA lid domain AAA_19 PF13245.6 EXF81921.1 - 2.2e-13 50.7 0.1 1e-06 29.1 0.0 4.6 3 1 0 3 3 3 2 AAA domain AAA_5 PF07728.14 EXF81921.1 - 3.6e-09 36.7 0.3 0.063 13.3 0.0 4.7 4 0 0 4 4 4 3 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EXF81921.1 - 6.8e-09 36.3 1.1 0.034 14.5 0.0 4.9 4 1 0 4 4 4 2 AAA ATPase domain AAA_22 PF13401.6 EXF81921.1 - 6.1e-07 29.8 10.6 3.5 7.9 0.2 7.0 5 2 0 5 5 4 2 AAA domain Mg_chelatase PF01078.21 EXF81921.1 - 1.6e-06 27.7 0.1 0.3 10.4 0.0 3.8 3 0 0 3 3 3 2 Magnesium chelatase, subunit ChlI AAA_24 PF13479.6 EXF81921.1 - 2.4e-06 27.4 0.4 1.9 8.2 0.0 4.0 3 1 0 3 3 3 3 AAA domain ResIII PF04851.15 EXF81921.1 - 3.3e-05 24.0 0.3 0.097 12.7 0.0 5.2 6 0 0 6 6 6 1 Type III restriction enzyme, res subunit RNA_helicase PF00910.22 EXF81921.1 - 5.5e-05 23.5 0.0 3.7 8.0 0.0 3.7 3 0 0 3 3 3 2 RNA helicase RuvB_N PF05496.12 EXF81921.1 - 5.9e-05 22.9 0.3 2.9 7.6 0.0 4.4 4 1 0 4 4 4 2 Holliday junction DNA helicase RuvB P-loop domain Torsin PF06309.11 EXF81921.1 - 6.6e-05 23.0 0.0 2.8 8.1 0.0 3.8 3 0 0 3 3 3 2 Torsin IstB_IS21 PF01695.17 EXF81921.1 - 0.00011 21.9 0.0 1.5 8.5 0.0 3.6 3 0 0 3 3 3 1 IstB-like ATP binding protein DUF2075 PF09848.9 EXF81921.1 - 0.0014 18.0 3.5 0.08 12.2 0.0 4.7 5 0 0 5 5 5 1 Uncharacterized conserved protein (DUF2075) Helicase_RecD PF05127.14 EXF81921.1 - 0.0016 18.3 0.5 0.29 10.9 0.0 3.4 3 0 0 3 3 2 1 Helicase AAA_7 PF12775.7 EXF81921.1 - 0.0028 17.2 0.0 5.3 6.5 0.0 3.4 3 0 0 3 3 3 1 P-loop containing dynein motor region AAA_18 PF13238.6 EXF81921.1 - 0.0055 17.2 9.3 10 6.7 0.1 5.4 5 0 0 5 5 4 0 AAA domain AAA_33 PF13671.6 EXF81921.1 - 0.081 13.1 12.8 1.8 8.7 0.0 4.9 5 0 0 5 5 4 0 AAA domain NTPase_1 PF03266.15 EXF81921.1 - 0.14 12.0 2.0 20 5.0 0.1 4.2 5 0 0 5 5 5 0 NTPase SRP54 PF00448.22 EXF81921.1 - 0.2 11.2 2.1 11 5.6 0.0 3.5 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain Dynein_attach_N PF15867.5 EXF81921.1 - 3.9 7.5 6.8 1.9 8.5 1.3 2.7 2 0 0 2 2 2 0 Dynein attachment factor N-terminus HDV_ag PF01517.18 EXF81921.1 - 7.1 6.4 14.6 0.22 11.3 2.1 2.6 2 0 0 2 2 2 0 Hepatitis delta virus delta antigen Lysine_decarbox PF03641.14 EXF81923.1 - 1.5e-28 99.5 0.0 2.1e-28 99.1 0.0 1.2 1 0 0 1 1 1 1 Possible lysine decarboxylase LDcluster4 PF18306.1 EXF81923.1 - 2e-06 27.5 2.2 5.4e-06 26.1 2.1 1.7 1 1 0 1 1 1 1 SLOG cluster4 family DAGK_cat PF00781.24 EXF81923.1 - 0.25 11.0 1.1 18 5.0 0.1 2.7 3 0 0 3 3 3 0 Diacylglycerol kinase catalytic domain LRR_6 PF13516.6 EXF81925.1 - 6.8e-15 53.8 21.3 0.64 10.2 0.0 12.0 12 0 0 12 12 12 5 Leucine Rich repeat F-box-like PF12937.7 EXF81925.1 - 3.6e-12 46.0 0.4 8.4e-12 44.8 0.4 1.7 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.7 EXF81925.1 - 1.8e-09 37.7 13.3 0.44 11.0 0.1 7.3 3 2 3 8 8 8 5 Leucine Rich repeats (2 copies) F-box PF00646.33 EXF81925.1 - 2.2e-05 24.2 0.1 0.0001 22.1 0.1 2.1 1 0 0 1 1 1 1 F-box domain RBD-FIP PF09457.10 EXF81925.1 - 0.18 11.8 0.0 2 8.4 0.0 2.3 2 0 0 2 2 2 0 FIP domain LRR_1 PF00560.33 EXF81925.1 - 5.2 8.0 21.8 1.5e+02 3.6 0.0 8.5 8 2 0 8 8 8 0 Leucine Rich Repeat SAM_Ste50p PF09235.10 EXF81925.1 - 10 6.5 14.3 24 5.3 0.1 6.1 4 1 3 7 7 7 0 Ste50p, sterile alpha motif Chalcone_2 PF16035.5 EXF81927.1 - 5.3e-81 271.3 0.0 7.3e-81 270.8 0.0 1.2 1 0 0 1 1 1 1 Chalcone isomerase like Chalcone_3 PF16036.5 EXF81927.1 - 0.0019 18.3 0.2 0.062 13.4 0.1 2.3 1 1 1 2 2 2 1 Chalcone isomerase-like Glutaredoxin PF00462.24 EXF81928.1 - 3.6e-18 65.5 0.0 5.6e-18 64.9 0.0 1.3 1 0 0 1 1 1 1 Glutaredoxin Thioredoxin_2 PF13098.6 EXF81928.1 - 0.00078 19.9 0.1 0.0012 19.2 0.1 1.5 1 1 0 1 1 1 1 Thioredoxin-like domain DUF836 PF05768.14 EXF81928.1 - 0.0021 18.4 0.0 0.0029 18.0 0.0 1.3 1 0 0 1 1 1 1 Glutaredoxin-like domain (DUF836) Thioredoxin PF00085.20 EXF81928.1 - 0.0037 17.2 0.0 0.0039 17.2 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin DSBA PF01323.20 EXF81928.1 - 0.0037 17.1 0.2 0.0092 15.8 0.1 1.6 1 1 1 2 2 2 1 DSBA-like thioredoxin domain Thioredoxin_9 PF14595.6 EXF81928.1 - 0.016 15.0 0.0 0.02 14.7 0.0 1.1 1 0 0 1 1 1 0 Thioredoxin TraF PF13728.6 EXF81928.1 - 0.037 13.9 0.0 0.041 13.7 0.0 1.1 1 0 0 1 1 1 0 F plasmid transfer operon protein GST_N_3 PF13417.6 EXF81928.1 - 0.054 13.9 0.0 0.087 13.2 0.0 1.3 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain Thioredoxin_3 PF13192.6 EXF81928.1 - 0.14 12.2 0.0 0.21 11.6 0.0 1.4 1 1 0 1 1 1 0 Thioredoxin domain BAG PF02179.16 EXF81929.1 - 3.8e-21 75.3 2.2 6.3e-21 74.6 2.2 1.4 1 0 0 1 1 1 1 BAG domain ubiquitin PF00240.23 EXF81929.1 - 7e-05 22.5 0.0 0.0003 20.5 0.0 1.9 2 0 0 2 2 2 1 Ubiquitin family Ubiquitin_5 PF18037.1 EXF81929.1 - 0.0066 16.8 0.0 0.03 14.7 0.0 2.0 2 0 0 2 2 2 1 Ubiquitin-like domain Ribosomal_L13 PF00572.18 EXF81930.1 - 4.5e-11 43.1 0.0 4e-09 36.8 0.0 2.3 1 1 0 1 1 1 1 Ribosomal protein L13 DSBA PF01323.20 EXF81930.1 - 0.035 13.9 0.1 0.046 13.5 0.1 1.4 1 0 0 1 1 1 0 DSBA-like thioredoxin domain Swi5 PF07061.11 EXF81931.1 - 1.9e-19 69.5 0.1 2.1e-19 69.4 0.1 1.0 1 0 0 1 1 1 1 Swi5 Ank_2 PF12796.7 EXF81932.1 - 7.8e-18 64.8 0.1 2.4e-07 31.2 0.0 5.5 4 2 1 5 5 5 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EXF81932.1 - 7.3e-16 56.7 10.5 0.0058 17.1 0.0 9.4 10 0 0 10 10 10 4 Ankyrin repeat Ank_4 PF13637.6 EXF81932.1 - 1.1e-15 57.8 4.5 0.039 14.5 0.0 7.6 6 1 3 9 9 9 6 Ankyrin repeats (many copies) Clr5 PF14420.6 EXF81932.1 - 3.7e-12 46.3 2.9 1e-11 44.9 2.9 1.7 1 0 0 1 1 1 1 Clr5 domain Ank PF00023.30 EXF81932.1 - 5.3e-07 29.8 6.5 0.021 15.3 0.1 6.0 7 0 0 7 7 7 2 Ankyrin repeat Ank_5 PF13857.6 EXF81932.1 - 0.00043 20.5 2.5 4.5 7.7 0.0 5.3 5 1 1 6 6 6 1 Ankyrin repeats (many copies) CIDR1_gamma PF18562.1 EXF81932.1 - 0.16 12.1 1.4 0.37 10.9 1.4 1.5 1 0 0 1 1 1 0 Cysteine-Rich Interdomain Region 1 gamma Abhydrolase_1 PF00561.20 EXF81933.1 - 3.1e-19 69.6 0.0 1e-18 68.0 0.0 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EXF81933.1 - 3e-13 50.9 0.0 4.2e-13 50.4 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EXF81933.1 - 1.2e-12 47.6 0.0 2.1e-12 46.8 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Ndr PF03096.14 EXF81933.1 - 3.8e-05 22.5 0.0 6.4e-05 21.8 0.0 1.3 1 0 0 1 1 1 1 Ndr family Abhydrolase_5 PF12695.7 EXF81933.1 - 0.033 14.0 0.0 0.088 12.6 0.0 1.7 2 0 0 2 2 2 0 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 EXF81933.1 - 0.083 12.4 0.5 6.9 6.1 0.0 2.6 2 1 0 2 2 2 0 Prolyl oligopeptidase family COesterase PF00135.28 EXF81935.1 - 1.9e-71 241.5 0.0 3.1e-71 240.8 0.0 1.2 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EXF81935.1 - 5e-05 23.3 0.0 0.00013 21.9 0.0 1.7 2 0 0 2 2 2 1 alpha/beta hydrolase fold Epimerase PF01370.21 EXF81936.1 - 1.6e-09 37.6 0.0 1.9e-09 37.4 0.0 1.0 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EXF81936.1 - 4.3e-07 29.7 0.0 4.8e-07 29.5 0.0 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 EXF81936.1 - 9.8e-07 28.0 0.0 1.2e-06 27.8 0.0 1.0 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 EXF81936.1 - 5.4e-06 26.4 0.0 6.4e-06 26.2 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding NAD_binding_4 PF07993.12 EXF81936.1 - 5.9e-05 22.4 0.0 0.00061 19.0 0.0 1.9 2 0 0 2 2 2 1 Male sterility protein KR PF08659.10 EXF81936.1 - 0.00017 21.6 0.0 0.00019 21.4 0.0 1.1 1 0 0 1 1 1 1 KR domain adh_short PF00106.25 EXF81936.1 - 0.00017 21.1 0.0 0.00023 20.7 0.0 1.2 1 1 0 1 1 1 1 short chain dehydrogenase Polysacc_synt_2 PF02719.15 EXF81936.1 - 0.0029 16.8 0.0 0.0032 16.7 0.0 1.0 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein F420_oxidored PF03807.17 EXF81936.1 - 0.0033 18.0 0.0 0.0045 17.5 0.0 1.3 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent RmlD_sub_bind PF04321.17 EXF81936.1 - 0.026 13.7 0.0 0.033 13.3 0.0 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain NmrA PF05368.13 EXF81936.1 - 0.032 13.8 0.0 0.037 13.6 0.0 1.2 1 0 0 1 1 1 0 NmrA-like family Sacchrp_dh_NADP PF03435.18 EXF81936.1 - 0.11 12.7 0.0 0.14 12.5 0.0 1.2 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain adh_short_C2 PF13561.6 EXF81936.1 - 0.18 11.3 0.1 0.21 11.1 0.1 1.3 1 1 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 EXF81937.1 - 0.005 16.3 0.0 0.0067 15.9 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family adh_short PF00106.25 EXF81938.1 - 6.2e-25 87.8 0.0 3.3e-24 85.4 0.0 1.9 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF81938.1 - 1.5e-17 63.9 0.0 4.1e-17 62.5 0.0 1.5 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF81938.1 - 1e-06 28.8 0.1 1.8e-06 28.0 0.1 1.4 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EXF81938.1 - 5.8e-05 22.7 0.0 8.6e-05 22.1 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Eno-Rase_NADH_b PF12242.8 EXF81938.1 - 0.068 12.9 0.1 0.26 11.0 0.0 2.0 2 0 0 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase GDP_Man_Dehyd PF16363.5 EXF81938.1 - 0.21 11.0 0.0 15 4.9 0.0 2.1 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase Methyltransf_23 PF13489.6 EXF81939.1 - 6.3e-11 42.4 0.0 8.4e-11 42.0 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF81939.1 - 3.2e-07 30.9 0.0 5.6e-07 30.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF81939.1 - 6.6e-07 30.0 0.0 1.2e-06 29.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF81939.1 - 3.5e-06 27.7 0.0 5e-06 27.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF81939.1 - 8.1e-06 25.7 0.0 1.1e-05 25.2 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EXF81939.1 - 0.00088 18.7 0.0 0.0012 18.3 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_24 PF13578.6 EXF81939.1 - 0.008 17.2 0.0 0.011 16.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PRMT5 PF05185.16 EXF81939.1 - 0.041 13.7 0.0 0.053 13.4 0.0 1.1 1 0 0 1 1 1 0 PRMT5 arginine-N-methyltransferase PCMT PF01135.19 EXF81939.1 - 0.081 12.7 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) RrnaAD PF00398.20 EXF81939.1 - 0.13 11.3 0.0 0.21 10.6 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase CN_hydrolase PF00795.22 EXF81940.1 - 7.3e-43 146.8 0.0 8.7e-43 146.5 0.0 1.1 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase FAD_binding_4 PF01565.23 EXF81941.1 - 3.1e-16 59.4 0.0 6.4e-16 58.4 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain Sugar_tr PF00083.24 EXF81943.1 - 1.5e-114 383.3 25.6 1.9e-114 383.1 25.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF81943.1 - 6.1e-24 84.6 28.8 1.7e-23 83.2 19.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EXF81943.1 - 8.7e-07 27.8 23.0 0.0009 17.9 0.9 3.2 3 1 0 3 3 3 2 MFS/sugar transport protein DUF1201 PF06716.11 EXF81943.1 - 3.1 7.9 9.6 0.4 10.7 3.8 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1201) Sulfatase PF00884.23 EXF81944.1 - 7.6e-62 209.5 0.3 1e-61 209.0 0.3 1.2 1 0 0 1 1 1 1 Sulfatase DUF4976 PF16347.5 EXF81944.1 - 4.8e-21 74.9 6.5 5e-20 71.7 6.5 2.3 1 1 0 1 1 1 1 Domain of unknown function (DUF4976) Phosphodiest PF01663.22 EXF81944.1 - 1.5e-09 38.0 2.4 5.6e-09 36.0 2.4 1.9 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase DUF229 PF02995.17 EXF81944.1 - 0.00071 18.3 0.0 0.0026 16.4 0.1 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF229) Zn_clus PF00172.18 EXF81945.1 - 7e-14 51.7 25.9 1.7e-07 31.3 12.7 2.6 2 0 0 2 2 2 2 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EXF81945.1 - 1.3e-06 27.7 0.0 2.5e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Glyco_hydro_3 PF00933.21 EXF81947.1 - 1.7e-48 165.7 0.0 2.2e-48 165.3 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.22 EXF81947.1 - 4e-39 134.7 0.0 6.6e-39 134.0 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.6 EXF81947.1 - 7e-15 54.9 0.1 1.5e-14 53.8 0.1 1.6 1 0 0 1 1 1 1 Fibronectin type III-like domain MFS_1 PF07690.16 EXF81948.1 - 2e-45 155.3 53.3 6.6e-45 153.6 50.5 2.8 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF81948.1 - 2.2e-10 40.0 25.5 2.8e-10 39.6 5.9 2.9 2 1 1 3 3 3 2 Sugar (and other) transporter TRI12 PF06609.13 EXF81948.1 - 2.3e-09 36.2 18.8 6.2e-09 34.8 18.8 1.6 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) HemY_N PF07219.13 EXF81948.1 - 0.43 10.8 2.6 2.8 8.2 0.4 2.9 2 0 0 2 2 2 0 HemY protein N-terminus Fungal_trans PF04082.18 EXF81949.1 - 1.7e-12 47.0 0.0 2.4e-12 46.5 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF81949.1 - 1.5e-08 34.6 9.6 2.6e-08 33.8 9.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain GMC_oxred_N PF00732.19 EXF81950.1 - 9.2e-65 218.9 0.0 1.3e-64 218.5 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EXF81950.1 - 6e-32 111.1 0.0 1e-31 110.4 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase Lycopene_cycl PF05834.12 EXF81950.1 - 0.00012 21.3 0.2 0.0002 20.6 0.2 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein Thi4 PF01946.17 EXF81950.1 - 0.011 15.0 1.0 0.024 13.9 0.2 1.9 2 0 0 2 2 2 0 Thi4 family FAD_binding_2 PF00890.24 EXF81950.1 - 0.017 14.2 2.2 2.2 7.3 1.3 2.3 2 0 0 2 2 2 0 FAD binding domain Sugar_tr PF00083.24 EXF81951.1 - 5.3e-110 368.4 21.5 1.5e-109 366.9 21.5 1.6 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF81951.1 - 2.9e-22 79.1 52.1 1.2e-16 60.6 24.9 2.8 1 1 2 3 3 3 2 Major Facilitator Superfamily DUF910 PF06014.11 EXF81951.1 - 0.074 13.1 0.0 0.16 12.0 0.0 1.5 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF910) DUF89 PF01937.19 EXF81952.1 - 8.7e-136 452.5 0.1 1e-135 452.3 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF89 Lustrin_cystein PF14625.6 EXF81954.1 - 0.58 10.6 10.0 4.5 7.7 1.1 2.6 2 0 0 2 2 2 0 Lustrin, cysteine-rich repeated domain HET PF06985.11 EXF81957.1 - 1.8e-26 93.2 0.1 3.3e-26 92.4 0.1 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) MFS_1 PF07690.16 EXF81958.1 - 1.4e-36 126.2 25.4 1.4e-36 126.2 25.4 1.6 1 1 1 2 2 2 1 Major Facilitator Superfamily MFS_4 PF06779.14 EXF81958.1 - 4e-06 26.4 2.7 4e-06 26.4 2.7 2.1 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB DUF2206 PF09971.9 EXF81958.1 - 0.0011 17.8 0.1 0.0011 17.8 0.1 1.8 2 0 0 2 2 2 1 Predicted membrane protein (DUF2206) Fungal_trans_2 PF11951.8 EXF81959.1 - 8e-08 31.5 0.6 0.00055 18.9 0.0 2.2 2 0 0 2 2 2 2 Fungal specific transcription factor domain Transp_cyt_pur PF02133.15 EXF81960.1 - 1.5e-11 43.8 22.7 1.5e-11 43.8 22.7 1.9 1 1 1 2 2 2 1 Permease for cytosine/purines, uracil, thiamine, allantoin CFEM PF05730.11 EXF81961.1 - 8.5e-10 38.6 10.9 2e-09 37.4 10.9 1.6 1 0 0 1 1 1 1 CFEM domain Peptidase_M43 PF05572.13 EXF81962.1 - 8.6e-06 25.7 0.2 1.8e-05 24.7 0.2 1.5 1 0 0 1 1 1 1 Pregnancy-associated plasma protein-A Reprolysin_5 PF13688.6 EXF81962.1 - 0.046 13.9 0.3 0.11 12.6 0.3 1.7 1 0 0 1 1 1 0 Metallo-peptidase family M12 BAR_2 PF10455.9 EXF81963.1 - 0.2 10.7 0.6 13 4.8 0.1 2.2 2 0 0 2 2 2 0 Bin/amphiphysin/Rvs domain for vesicular trafficking Sod_Fe_C PF02777.18 EXF81964.1 - 1.5e-33 115.0 0.4 3e-33 114.0 0.1 1.6 2 0 0 2 2 2 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 EXF81964.1 - 5.1e-30 103.8 5.0 5.1e-30 103.8 5.0 2.1 2 1 0 2 2 2 1 Iron/manganese superoxide dismutases, alpha-hairpin domain MRJP PF03022.16 EXF81967.1 - 1.7e-32 112.9 0.0 2.1e-32 112.6 0.0 1.1 1 0 0 1 1 1 1 Major royal jelly protein SGL PF08450.12 EXF81967.1 - 0.00081 19.0 0.1 0.0047 16.6 0.0 2.1 2 0 0 2 2 2 1 SMP-30/Gluconolactonase/LRE-like region NHL PF01436.21 EXF81967.1 - 0.085 12.9 0.2 33 4.8 0.0 3.3 3 0 0 3 3 3 0 NHL repeat Peptidase_M20 PF01546.28 EXF81969.1 - 1.6e-18 67.2 0.0 9e-18 64.7 0.0 2.0 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EXF81969.1 - 2.9e-18 65.8 0.0 4.6e-18 65.1 0.0 1.3 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 EXF81969.1 - 3.7e-06 26.8 0.0 5.6e-06 26.2 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M28 FMO-like PF00743.19 EXF81970.1 - 5.9e-52 176.8 0.0 5.8e-49 166.9 0.0 2.2 2 0 0 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EXF81970.1 - 4.3e-17 62.3 0.0 2.5e-13 50.0 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EXF81970.1 - 4.1e-11 42.7 0.0 2.4e-09 36.9 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EXF81970.1 - 1.3e-08 35.0 0.0 3.1e-08 33.7 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 EXF81970.1 - 1.3e-06 27.8 0.2 1.5e-05 24.3 0.0 2.6 4 0 0 4 4 4 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 EXF81970.1 - 0.0015 18.6 0.2 0.53 10.3 0.1 3.2 2 1 0 2 2 2 1 FAD-NAD(P)-binding Shikimate_DH PF01488.20 EXF81970.1 - 0.0015 18.6 0.0 0.24 11.5 0.0 2.5 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.19 EXF81970.1 - 0.0079 15.6 0.0 0.44 9.9 0.0 2.4 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_7 PF13241.6 EXF81970.1 - 0.098 13.1 0.0 19 5.8 0.0 2.8 2 1 0 2 2 2 0 Putative NAD(P)-binding TauD PF02668.16 EXF81971.1 - 7.7e-32 111.1 1.1 1.1e-31 110.6 0.9 1.4 1 1 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family CsiD PF08943.10 EXF81971.1 - 0.023 13.8 0.0 0.036 13.2 0.0 1.2 1 0 0 1 1 1 0 CsiD ABM PF03992.16 EXF81972.1 - 0.002 18.2 0.4 0.053 13.6 0.0 2.9 3 1 0 3 3 3 1 Antibiotic biosynthesis monooxygenase DUF1330 PF07045.11 EXF81972.1 - 0.069 13.5 0.0 1.4 9.3 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1330) FA_hydroxylase PF04116.13 EXF81973.1 - 5.2e-26 91.6 17.8 5.2e-26 91.6 17.8 2.2 2 1 0 2 2 2 1 Fatty acid hydroxylase superfamily MUG113 PF13455.6 EXF81975.1 - 1.2e-21 77.1 0.0 2.4e-21 76.2 0.0 1.5 1 0 0 1 1 1 1 Meiotically up-regulated gene 113 T5orf172 PF10544.9 EXF81975.1 - 9.8e-21 74.2 0.0 3e-20 72.7 0.0 1.8 1 0 0 1 1 1 1 T5orf172 domain DEAD PF00270.29 EXF81976.1 - 3.3e-39 134.5 0.1 5.5e-39 133.7 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EXF81976.1 - 1.1e-24 86.9 0.3 2.7e-23 82.4 0.1 2.5 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EXF81976.1 - 5.5e-08 33.0 0.0 1.3e-07 31.8 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 EXF81976.1 - 0.033 13.5 0.2 0.15 11.4 0.1 1.9 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit DUF4844 PF16133.5 EXF81976.1 - 0.095 13.2 0.6 0.22 12.1 0.6 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4844) Rpr2 PF04032.16 EXF81977.1 - 8.4e-25 86.9 1.0 1.2e-24 86.4 1.0 1.2 1 0 0 1 1 1 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain Pyridoxal_deC PF00282.19 EXF81978.1 - 1.2e-66 224.9 0.0 1.9e-66 224.3 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.19 EXF81978.1 - 0.00024 20.2 0.0 0.00039 19.5 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class-V OPT PF03169.15 EXF81979.1 - 2.3e-188 627.7 53.7 2.6e-188 627.5 53.7 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein DUF2937 PF11157.8 EXF81979.1 - 0.03 14.0 0.1 8.5 6.1 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2937) EIAV_GP90 PF00971.18 EXF81979.1 - 0.56 8.8 4.9 0.38 9.4 0.1 2.2 2 0 0 2 2 2 0 EIAV coat protein, gp90 BES1_N PF05687.13 EXF81981.1 - 0.043 14.2 4.5 0.055 13.9 4.5 1.1 1 0 0 1 1 1 0 BES1/BZR1 plant transcription factor, N-terminal Spt20 PF12090.8 EXF81981.1 - 0.13 11.9 13.9 0.14 11.7 13.9 1.1 1 0 0 1 1 1 0 Spt20 family Pinin_SDK_N PF04697.13 EXF81981.1 - 0.13 12.9 4.8 0.091 13.4 3.7 1.3 1 1 0 1 1 1 0 pinin/SDK conserved region TFIIA PF03153.13 EXF81981.1 - 0.26 11.3 12.8 0.27 11.2 12.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Roughex PF06020.11 EXF81981.1 - 0.85 8.7 3.4 0.91 8.6 3.4 1.1 1 0 0 1 1 1 0 Drosophila roughex protein Presenilin PF01080.17 EXF81981.1 - 3 6.5 5.0 2.9 6.6 5.0 1.0 1 0 0 1 1 1 0 Presenilin p450 PF00067.22 EXF81983.1 - 7.7e-46 156.8 0.0 1.2e-44 152.8 0.0 2.0 1 1 0 1 1 1 1 Cytochrome P450 MFS_1 PF07690.16 EXF81984.1 - 5e-38 130.9 33.4 3.6e-37 128.1 21.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily adh_short PF00106.25 EXF81985.1 - 7.5e-24 84.3 0.0 6.6e-23 81.2 0.0 2.2 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF81985.1 - 1.8e-14 53.8 0.1 1.5e-12 47.6 0.1 2.2 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF81985.1 - 8.4e-08 32.3 1.9 1.4e-07 31.6 0.7 1.9 1 1 1 2 2 2 1 KR domain DUF3446 PF11928.8 EXF81985.1 - 0.00047 20.4 3.0 0.00047 20.4 3.0 1.7 2 0 0 2 2 2 1 Early growth response N-terminal domain Epimerase PF01370.21 EXF81985.1 - 0.0024 17.4 0.9 0.027 13.9 0.9 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EXF81985.1 - 0.0031 17.0 0.5 0.12 11.8 0.4 2.1 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase Eno-Rase_NADH_b PF12242.8 EXF81985.1 - 0.12 12.2 0.0 0.26 11.1 0.0 1.6 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase adh_short PF00106.25 EXF81986.1 - 1.2e-53 181.5 0.0 1.8e-53 180.9 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF81986.1 - 6.9e-38 130.5 0.0 1.1e-37 129.9 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF81986.1 - 1.3e-10 41.5 2.1 1.6e-10 41.2 0.3 1.8 2 0 0 2 2 2 1 KR domain Epimerase PF01370.21 EXF81986.1 - 3e-05 23.6 0.2 0.00014 21.4 0.2 2.1 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF1776 PF08643.10 EXF81986.1 - 0.0005 19.5 0.0 0.00079 18.9 0.0 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) UPF0020 PF01170.18 EXF81988.1 - 0.072 12.8 0.0 0.11 12.2 0.0 1.2 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 CALM_bind PF16025.5 EXF81988.1 - 0.16 12.4 3.8 0.3 11.6 3.8 1.4 1 0 0 1 1 1 0 Calcium-dependent calmodulin binding PI3_PI4_kinase PF00454.27 EXF81989.1 - 1.2e-48 166.1 0.0 3.2e-48 164.7 0.0 1.7 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FAT PF02259.23 EXF81989.1 - 1.4e-12 47.5 2.9 3.9e-12 46.0 2.9 1.8 1 1 0 1 1 1 1 FAT domain FATC PF02260.20 EXF81989.1 - 2.3e-11 43.3 0.1 8.4e-11 41.5 0.1 2.0 1 0 0 1 1 1 1 FATC domain Cullin PF00888.22 EXF81990.1 - 3.2e-179 597.5 0.6 4.1e-179 597.1 0.6 1.1 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 EXF81990.1 - 1.7e-24 85.6 0.3 5.2e-24 84.1 0.3 1.9 1 0 0 1 1 1 1 Cullin protein neddylation domain HbrB PF08539.11 EXF81990.1 - 0.074 13.0 0.0 0.27 11.2 0.0 1.9 1 0 0 1 1 1 0 HbrB-like RL10P_insert PF17777.1 EXF81991.1 - 7.1e-23 80.4 0.0 1.2e-22 79.7 0.0 1.4 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_L10 PF00466.20 EXF81991.1 - 1.7e-21 76.2 0.0 2.5e-21 75.7 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L10 DUF4710 PF15828.5 EXF81991.1 - 0.05 13.7 0.3 0.086 13.0 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4710) U1snRNP70_N PF12220.8 EXF81992.1 - 4.7e-25 88.1 5.1 9.3e-25 87.1 5.1 1.5 1 0 0 1 1 1 1 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal RRM_1 PF00076.22 EXF81992.1 - 8.8e-12 44.7 0.1 4e-10 39.4 0.0 2.9 2 1 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EXF81992.1 - 0.0031 17.6 0.0 0.0055 16.8 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif L51_S25_CI-B8 PF05047.16 EXF81993.1 - 6.3e-17 61.2 0.1 1.5e-16 60.0 0.1 1.7 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain TIM PF00121.18 EXF81994.1 - 3.8e-87 291.7 0.6 4.3e-87 291.5 0.6 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase zf-C2H2 PF00096.26 EXF81996.1 - 0.0065 16.9 3.4 0.2 12.2 0.1 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EXF81996.1 - 0.0066 17.2 3.1 2.1 9.4 0.9 3.2 2 0 0 2 2 2 2 C2H2-type zinc finger Zn_clus PF00172.18 EXF81997.1 - 0.00014 21.9 4.6 0.008 16.3 2.2 2.5 2 0 0 2 2 2 2 Fungal Zn(2)-Cys(6) binuclear cluster domain LRRNT PF01462.18 EXF81997.1 - 4.4 7.0 7.8 0.26 11.0 1.4 2.2 2 0 0 2 2 2 0 Leucine rich repeat N-terminal domain Zn_clus PF00172.18 EXF81999.1 - 0.00046 20.3 12.2 0.0008 19.5 12.2 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain IMUP PF15761.5 EXF81999.1 - 0.0038 17.9 5.0 0.011 16.4 5.0 1.7 1 0 0 1 1 1 1 Immortalisation up-regulated protein MT PF12777.7 EXF81999.1 - 0.086 11.8 0.1 7.6 5.5 0.0 2.2 1 1 1 2 2 2 0 Microtubule-binding stalk of dynein motor SR-25 PF10500.9 EXF81999.1 - 0.2 11.2 3.9 0.37 10.4 3.9 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein SET PF00856.28 EXF82001.1 - 2.7e-10 40.9 0.3 4.8e-09 36.8 0.0 2.7 2 1 0 2 2 2 1 SET domain TPR_2 PF07719.17 EXF82001.1 - 0.00019 21.3 11.1 0.067 13.3 0.1 4.9 5 0 0 5 5 5 2 Tetratricopeptide repeat GLEYA PF10528.9 EXF82001.1 - 0.017 15.6 0.0 0.039 14.4 0.0 1.6 1 0 0 1 1 1 0 GLEYA domain TPR_12 PF13424.6 EXF82001.1 - 0.043 14.1 8.4 0.076 13.3 0.6 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.6 EXF82001.1 - 0.22 11.9 3.2 1.3 9.5 0.1 2.8 2 1 0 3 3 3 0 Alkyl sulfatase dimerisation TPR_16 PF13432.6 EXF82001.1 - 0.29 11.8 8.2 0.072 13.7 2.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat KTI12 PF08433.10 EXF82003.1 - 3.9e-68 229.9 0.0 7.9e-68 228.8 0.0 1.5 1 1 0 1 1 1 1 Chromatin associated protein KTI12 AAA_18 PF13238.6 EXF82003.1 - 0.0011 19.5 0.1 0.009 16.6 0.0 2.4 3 0 0 3 3 3 1 AAA domain AAA_33 PF13671.6 EXF82003.1 - 0.0028 17.8 0.3 0.0073 16.5 0.3 1.8 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EXF82003.1 - 0.0093 16.2 0.0 0.02 15.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain CPT PF07931.12 EXF82003.1 - 0.027 14.3 0.1 0.077 12.8 0.1 1.6 1 1 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein RPOL_N PF14700.6 EXF82003.1 - 0.031 13.7 0.1 0.075 12.4 0.1 1.6 2 0 0 2 2 2 0 DNA-directed RNA polymerase N-terminal AAA_16 PF13191.6 EXF82003.1 - 0.047 14.1 0.1 0.13 12.6 0.0 1.8 1 1 0 1 1 1 0 AAA ATPase domain Orthopox_A36R PF05950.11 EXF82003.1 - 0.13 12.4 0.1 0.21 11.7 0.1 1.3 1 0 0 1 1 1 0 Orthopoxvirus A36R protein Dicty_REP PF05086.12 EXF82003.1 - 0.42 8.5 0.3 0.51 8.3 0.3 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein PalH PF08733.10 EXF82005.1 - 2.1e-110 368.8 1.2 2.8e-110 368.4 1.2 1.1 1 0 0 1 1 1 1 PalH/RIM21 CAAD PF14159.6 EXF82005.1 - 0.056 13.3 0.4 0.22 11.4 0.1 2.1 2 0 0 2 2 2 0 CAAD domains of cyanobacterial aminoacyl-tRNA synthetase TRAM_LAG1_CLN8 PF03798.16 EXF82006.1 - 4.1e-36 124.6 19.7 7e-36 123.8 19.7 1.4 1 0 0 1 1 1 1 TLC domain TRAM1 PF08390.11 EXF82006.1 - 7.5e-26 89.6 1.7 2.6e-25 87.9 0.0 2.4 2 0 0 2 2 2 1 TRAM1-like protein ABC_tran PF00005.27 EXF82007.1 - 3.4e-32 111.8 0.1 1.6e-31 109.6 0.0 2.1 2 0 0 2 2 2 1 ABC transporter ABC_membrane PF00664.23 EXF82007.1 - 1.8e-29 103.3 8.6 1.8e-29 103.3 8.6 2.0 2 0 0 2 2 2 1 ABC transporter transmembrane region SMC_N PF02463.19 EXF82007.1 - 2.2e-06 27.3 0.1 2e-05 24.1 0.0 2.1 1 1 1 3 3 3 1 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 EXF82007.1 - 0.011 15.6 0.0 0.025 14.5 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase 4HB_MCP_1 PF12729.7 EXF82007.1 - 0.056 13.0 1.2 0.1 12.1 1.2 1.4 1 0 0 1 1 1 0 Four helix bundle sensory module for signal transduction AAA_29 PF13555.6 EXF82007.1 - 0.058 13.1 0.1 0.23 11.2 0.1 2.0 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.6 EXF82007.1 - 0.14 12.5 0.0 0.33 11.3 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain DND1_DSRM PF14709.7 EXF82009.1 - 0.0013 18.9 0.2 0.0022 18.2 0.2 1.5 1 1 0 1 1 1 1 double strand RNA binding domain from DEAD END PROTEIN 1 dsrm PF00035.26 EXF82009.1 - 0.0076 16.9 0.0 0.016 15.9 0.0 1.6 1 0 0 1 1 1 1 Double-stranded RNA binding motif NTP_transferase PF00483.23 EXF82010.1 - 1.6e-52 178.6 0.0 3.6e-52 177.4 0.0 1.5 2 0 0 2 2 2 1 Nucleotidyl transferase Hexapep PF00132.24 EXF82010.1 - 7.6e-18 63.5 17.7 1e-10 40.9 1.4 3.6 2 2 1 3 3 3 3 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.7 EXF82010.1 - 9.7e-12 45.5 0.0 1.3e-11 45.1 0.0 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep_2 PF14602.6 EXF82010.1 - 1.2e-06 28.1 5.2 2.5e-05 23.9 0.4 3.3 3 1 0 3 3 3 1 Hexapeptide repeat of succinyl-transferase DUF4954 PF16314.5 EXF82010.1 - 0.0073 14.5 0.0 0.016 13.4 0.0 1.5 1 1 1 2 2 2 1 Domain of unknown function (DUF4954) IspD PF01128.19 EXF82010.1 - 0.0081 15.9 0.0 0.013 15.3 0.0 1.3 1 0 0 1 1 1 1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase CTP_transf_3 PF02348.19 EXF82010.1 - 0.01 15.8 0.0 0.031 14.2 0.0 1.7 2 0 0 2 2 2 0 Cytidylyltransferase FGGY_C PF02782.16 EXF82011.1 - 4.8e-72 241.8 0.5 8.5e-72 241.1 0.5 1.4 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 EXF82011.1 - 3.7e-65 219.9 0.0 4.9e-65 219.5 0.0 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain Ion_trans_2 PF07885.16 EXF82014.1 - 1.8e-32 111.2 24.1 3.1e-19 68.7 2.1 3.1 3 1 0 3 3 3 2 Ion channel Ion_trans PF00520.31 EXF82014.1 - 2.7e-05 23.5 11.9 0.00073 18.8 0.5 2.7 3 0 0 3 3 3 2 Ion transport protein SieB PF14163.6 EXF82014.1 - 0.24 10.9 1.4 1.2 8.6 0.0 2.8 3 0 0 3 3 3 0 Super-infection exclusion protein B Apt1 PF10351.9 EXF82014.1 - 0.29 10.0 3.2 0.52 9.1 3.2 1.4 1 0 0 1 1 1 0 Golgi-body localisation protein domain zf-RING_4 PF14570.6 EXF82016.1 - 3.6e-20 71.5 12.2 6.4e-20 70.7 12.2 1.4 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain RRM_1 PF00076.22 EXF82016.1 - 7.5e-11 41.7 0.1 3.4e-10 39.6 0.0 2.2 2 1 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-C3HC4_3 PF13920.6 EXF82016.1 - 8.9e-08 31.9 7.3 8.9e-08 31.9 7.3 1.6 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) Rtf2 PF04641.12 EXF82016.1 - 4.9e-05 22.8 4.1 0.00011 21.7 4.1 1.5 1 0 0 1 1 1 1 Rtf2 RING-finger zf-RING_2 PF13639.6 EXF82016.1 - 0.00026 21.2 10.0 0.00026 21.2 10.0 1.9 2 0 0 2 2 2 1 Ring finger domain SET_assoc PF11767.8 EXF82016.1 - 0.00051 19.6 0.0 0.0011 18.5 0.0 1.5 1 0 0 1 1 1 1 Histone lysine methyltransferase SET associated Prok-RING_4 PF14447.6 EXF82016.1 - 0.00054 19.8 9.1 0.072 13.0 9.7 2.6 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 FYVE PF01363.21 EXF82016.1 - 0.0098 16.0 3.4 0.023 14.8 3.4 1.6 1 0 0 1 1 1 1 FYVE zinc finger Nup35_RRM_2 PF14605.6 EXF82016.1 - 0.023 14.7 0.0 0.041 13.9 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Baculo_IE-1 PF05290.11 EXF82016.1 - 0.035 14.0 5.2 0.063 13.2 5.2 1.3 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) zf-C3HC4 PF00097.25 EXF82016.1 - 0.057 13.3 10.3 0.13 12.2 10.3 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EXF82016.1 - 0.12 12.3 10.3 0.26 11.3 10.3 1.6 1 0 0 1 1 1 0 zinc-RING finger domain zf-UDP PF14569.6 EXF82016.1 - 0.14 12.3 4.6 0.37 10.9 4.6 1.7 1 0 0 1 1 1 0 Zinc-binding RING-finger Peptidase_S55 PF05580.12 EXF82016.1 - 0.19 11.6 0.7 0.36 10.8 0.7 1.3 1 0 0 1 1 1 0 SpoIVB peptidase S55 zf-C3HC4_2 PF13923.6 EXF82016.1 - 0.67 9.9 9.9 1.6 8.6 9.9 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EXF82016.1 - 2.1 8.4 7.7 2.5 8.2 6.0 2.0 1 1 1 2 2 2 0 RING-type zinc-finger FYVE_2 PF02318.16 EXF82016.1 - 6.9 6.9 19.3 0.047 13.9 4.7 2.5 1 1 1 2 2 2 0 FYVE-type zinc finger Complex1_30kDa PF00329.19 EXF82017.1 - 2.8e-45 153.9 0.0 3.8e-45 153.5 0.0 1.2 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 30 Kd subunit DUF2087 PF09860.9 EXF82017.1 - 0.095 12.9 0.0 0.19 11.9 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2087) ASCH PF04266.14 EXF82019.1 - 0.088 13.4 0.0 0.37 11.4 0.0 2.0 2 0 0 2 2 2 0 ASCH domain CobT PF06213.12 EXF82020.1 - 3.6e-05 23.3 6.0 3.6e-05 23.3 6.0 2.1 3 0 0 3 3 3 1 Cobalamin biosynthesis protein CobT TFB6 PF17110.5 EXF82020.1 - 1.7 8.4 6.0 0.35 10.6 1.0 2.1 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH RNA_pol_Rpc4 PF05132.14 EXF82020.1 - 1.8 9.0 3.8 6.2 7.2 1.4 2.4 2 0 0 2 2 2 0 RNA polymerase III RPC4 DNA_pol_phi PF04931.13 EXF82020.1 - 2.3 6.2 14.4 4 5.4 14.4 1.2 1 0 0 1 1 1 0 DNA polymerase phi GCIP PF13324.6 EXF82020.1 - 2.9 7.4 6.3 5.7 6.5 6.3 1.4 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting NOA36 PF06524.12 EXF82020.1 - 3 7.1 14.0 6 6.1 14.0 1.4 1 0 0 1 1 1 0 NOA36 protein TRAP_alpha PF03896.16 EXF82020.1 - 8.1 5.5 9.7 2.1 7.5 4.9 2.0 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit TMEM119 PF15724.5 EXF82020.1 - 8.4 6.4 9.4 0.49 10.4 3.2 2.0 2 0 0 2 2 2 0 TMEM119 family Peptidase_S10 PF00450.22 EXF82021.1 - 2.4e-74 251.2 0.1 4.2e-74 250.4 0.1 1.3 1 1 0 1 1 1 1 Serine carboxypeptidase Fapy_DNA_glyco PF01149.24 EXF82022.1 - 1.1e-30 106.7 0.2 2.6e-30 105.4 0.0 1.8 2 0 0 2 2 2 1 Formamidopyrimidine-DNA glycosylase N-terminal domain H2TH PF06831.14 EXF82022.1 - 5.4e-20 71.2 0.0 1.3e-19 69.9 0.0 1.6 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase H2TH domain Cupin_2 PF07883.11 EXF82023.1 - 1.2e-13 50.6 0.0 1.8e-13 50.0 0.0 1.3 1 0 0 1 1 1 1 Cupin domain Cupin_1 PF00190.22 EXF82023.1 - 3.9e-06 26.5 0.0 5.1e-06 26.2 0.0 1.2 1 0 0 1 1 1 1 Cupin AraC_binding PF02311.19 EXF82023.1 - 0.00039 20.3 0.0 0.00054 19.9 0.0 1.2 1 0 0 1 1 1 1 AraC-like ligand binding domain CENP-C_C PF11699.8 EXF82023.1 - 0.0058 16.8 0.0 0.0089 16.2 0.0 1.3 1 0 0 1 1 1 1 Mif2/CENP-C like MannoseP_isomer PF01050.18 EXF82023.1 - 0.012 15.5 0.0 0.015 15.2 0.0 1.2 1 0 0 1 1 1 0 Mannose-6-phosphate isomerase Cupin_6 PF12852.7 EXF82023.1 - 0.029 14.1 0.0 0.037 13.8 0.0 1.2 1 0 0 1 1 1 0 Cupin PAS_9 PF13426.7 EXF82024.1 - 5.1e-15 55.6 0.0 7.8e-15 55.0 0.0 1.2 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 EXF82024.1 - 0.0012 18.8 0.0 0.042 13.9 0.0 2.3 1 1 0 1 1 1 1 PAS fold PAS_3 PF08447.12 EXF82024.1 - 0.08 13.2 0.0 4 7.8 0.0 2.2 2 0 0 2 2 2 0 PAS fold Putative_PNPOx PF01243.20 EXF82025.1 - 0.00031 20.9 0.0 0.069 13.3 0.0 2.7 3 0 0 3 3 3 2 Pyridoxamine 5'-phosphate oxidase FAD_binding_6 PF00970.24 EXF82025.1 - 0.016 15.5 0.0 0.88 10.0 0.0 2.4 1 1 0 1 1 1 0 Oxidoreductase FAD-binding domain KCH PF16944.5 EXF82026.1 - 7.2e-101 337.2 9.5 8.7e-101 336.9 9.5 1.1 1 0 0 1 1 1 1 Fungal potassium channel Pkinase PF00069.25 EXF82028.1 - 0.013 14.9 0.0 3.1 7.1 0.0 2.3 2 0 0 2 2 2 0 Protein kinase domain Collar PF07484.12 EXF82030.1 - 2.1e-11 43.7 0.2 7.2e-11 41.9 0.1 1.8 2 0 0 2 2 2 1 Phage Tail Collar Domain MFS_1 PF07690.16 EXF82032.1 - 6.9e-41 140.3 53.4 5e-40 137.5 52.0 2.4 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 EXF82032.1 - 2.8e-13 49.2 25.9 4.2e-13 48.6 25.9 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Abhydrolase_6 PF12697.7 EXF82034.1 - 1.6e-10 42.0 7.7 1.2e-09 39.1 7.6 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EXF82034.1 - 0.00014 21.2 0.0 0.00022 20.6 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EXF82034.1 - 0.0031 17.2 0.0 0.005 16.5 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EXF82034.1 - 0.19 11.2 0.1 0.43 10.0 0.0 1.7 2 0 0 2 2 2 0 Prolyl oligopeptidase family Chlorophyllase2 PF12740.7 EXF82034.1 - 0.2 10.5 0.0 0.32 9.9 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase enzyme Gryzun PF07919.12 EXF82035.1 - 1.7e-239 796.6 0.0 2e-239 796.3 0.0 1.1 1 0 0 1 1 1 1 Gryzun, putative trafficking through Golgi Foie-gras_1 PF11817.8 EXF82035.1 - 2.2e-94 315.9 6.7 4.1e-88 295.3 5.1 2.2 2 0 0 2 2 2 2 Foie gras liver health family 1 Gryzun-like PF12742.7 EXF82035.1 - 0.00026 20.9 0.0 0.00061 19.7 0.0 1.7 1 0 0 1 1 1 1 Gryzun, putative Golgi trafficking RXT2_N PF08595.11 EXF82036.1 - 2e-42 144.9 0.0 2e-42 144.9 0.0 3.0 3 1 0 3 3 3 1 RXT2-like, N-terminal PEMT PF04191.13 EXF82037.1 - 9.7e-34 116.0 2.8 1.7e-33 115.2 2.8 1.3 1 0 0 1 1 1 1 Phospholipid methyltransferase Nramp PF01566.18 EXF82038.1 - 8.3e-80 268.4 28.5 8.3e-80 268.4 28.5 2.4 2 1 0 2 2 2 1 Natural resistance-associated macrophage protein DUF5466 PF17554.2 EXF82038.1 - 0.17 12.1 1.8 16 5.8 0.1 3.0 2 0 0 2 2 2 0 Family of unknown function (DUF5466) PTPA PF03095.15 EXF82040.1 - 2.2e-112 375.4 0.0 2.6e-112 375.2 0.0 1.0 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein Cutinase PF01083.22 EXF82041.1 - 7.4e-46 156.3 1.4 8.8e-46 156.1 1.4 1.1 1 0 0 1 1 1 1 Cutinase PE-PPE PF08237.11 EXF82041.1 - 1.2e-05 24.9 0.1 1.8e-05 24.4 0.1 1.2 1 0 0 1 1 1 1 PE-PPE domain VirJ PF06057.11 EXF82041.1 - 0.042 13.7 0.0 0.061 13.2 0.0 1.2 1 0 0 1 1 1 0 Bacterial virulence protein (VirJ) Abhydrolase_2 PF02230.16 EXF82041.1 - 0.046 13.5 0.0 0.18 11.6 0.0 1.8 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Abhydrolase_1 PF00561.20 EXF82041.1 - 0.053 13.2 0.0 0.076 12.6 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold AT_hook PF02178.19 EXF82042.1 - 0.053 13.4 2.3 0.2 11.6 2.3 2.1 1 0 0 1 1 1 0 AT hook motif TniQ PF06527.11 EXF82042.1 - 0.58 10.9 6.5 3.9 8.2 3.8 2.7 2 1 0 2 2 2 0 TniQ PB1-F2 PF11986.8 EXF82043.1 - 0.17 12.1 0.0 0.27 11.5 0.0 1.5 1 0 0 1 1 1 0 Influenza A Proapoptotic protein p450 PF00067.22 EXF82044.1 - 7.9e-61 206.2 0.0 1e-60 205.9 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 FAD_binding_4 PF01565.23 EXF82045.1 - 3.6e-13 49.4 0.6 1.9e-09 37.4 0.2 2.4 1 1 1 2 2 2 2 FAD binding domain BBE PF08031.12 EXF82045.1 - 0.15 12.2 0.1 0.33 11.1 0.1 1.5 1 0 0 1 1 1 0 Berberine and berberine like PGM_PMM_IV PF00408.20 EXF82045.1 - 0.29 11.3 0.9 1.7 8.9 0.3 2.4 2 0 0 2 2 2 0 Phosphoglucomutase/phosphomannomutase, C-terminal domain Filament PF00038.21 EXF82046.1 - 0.00049 19.8 175.5 0.049 13.2 38.2 7.0 1 1 5 6 6 6 4 Intermediate filament protein Sec2p PF06428.11 EXF82046.1 - 0.00057 19.8 4.8 0.00057 19.8 4.8 15.1 2 1 8 14 14 14 2 GDP/GTP exchange factor Sec2p TPR_MLP1_2 PF07926.12 EXF82046.1 - 0.01 15.9 27.9 0.01 15.9 27.9 11.3 2 2 10 12 12 12 0 TPR/MLP1/MLP2-like protein Spc7 PF08317.11 EXF82046.1 - 0.028 13.3 207.1 0.016 14.1 29.5 8.5 1 1 8 9 9 9 0 Spc7 kinetochore protein NPC1_N PF16414.5 EXF82047.1 - 5.1e-84 281.6 9.1 7.2e-84 281.2 9.1 1.2 1 0 0 1 1 1 1 Niemann-Pick C1 N terminus Patched PF02460.18 EXF82047.1 - 3.3e-76 257.0 14.8 4e-48 164.1 0.4 2.6 3 0 0 3 3 3 2 Patched family Sterol-sensing PF12349.8 EXF82047.1 - 1.9e-51 174.0 6.5 1.9e-51 174.0 6.5 2.9 2 1 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation Folate_rec PF03024.14 EXF82047.1 - 3.4e-05 23.8 1.9 7.1e-05 22.7 1.9 1.4 1 0 0 1 1 1 1 Folate receptor family MMPL PF03176.15 EXF82047.1 - 0.0001 21.4 34.0 0.00068 18.7 9.9 3.0 3 0 0 3 3 3 2 MMPL family UvrD_C PF13361.6 EXF82049.1 - 2.8e-65 221.0 0.0 3.1e-64 217.6 0.0 2.0 2 0 0 2 2 2 1 UvrD-like helicase C-terminal domain UvrD-helicase PF00580.21 EXF82049.1 - 4.3e-63 213.7 0.2 2.2e-60 204.8 0.0 3.0 2 1 0 2 2 2 1 UvrD/REP helicase N-terminal domain AAA_19 PF13245.6 EXF82049.1 - 1.9e-30 106.1 0.0 5e-30 104.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.6 EXF82049.1 - 1.8e-14 53.3 0.0 3.5e-14 52.4 0.0 1.5 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_30 PF13604.6 EXF82049.1 - 3.4e-07 30.2 0.2 0.014 15.2 0.1 2.4 2 0 0 2 2 2 2 AAA domain AAA_12 PF13087.6 EXF82049.1 - 2.2e-05 24.2 0.0 0.00063 19.4 0.0 2.4 2 1 0 2 2 2 1 AAA domain Viral_helicase1 PF01443.18 EXF82049.1 - 4.6e-05 23.3 0.1 1.2 8.8 0.0 3.3 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase DUF3517 PF12030.8 EXF82049.1 - 0.021 13.8 0.0 0.19 10.6 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3517) DUF1631 PF07793.11 EXF82049.1 - 0.44 8.9 3.5 0.76 8.1 3.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1631) CcmD PF04995.14 EXF82050.1 - 0.0045 17.0 0.5 0.0088 16.1 0.5 1.4 1 0 0 1 1 1 1 Heme exporter protein D (CcmD) DUF2017 PF09438.10 EXF82051.1 - 0.41 10.5 1.4 0.64 9.9 0.2 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF2017) DUF2014 PF09427.10 EXF82052.1 - 2.6e-114 381.0 8.1 3.9e-114 380.4 8.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF2014) HLH PF00010.26 EXF82052.1 - 1.8e-16 59.8 0.9 1.8e-16 59.8 0.9 2.3 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain SUIM_assoc PF16619.5 EXF82052.1 - 0.13 12.4 4.1 0.51 10.4 4.1 2.0 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Spt5_N PF11942.8 EXF82052.1 - 1.5 9.9 8.2 0.26 12.3 2.9 2.5 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal Ceramidase_alk PF04734.13 EXF82053.1 - 1.3e-221 736.6 0.0 1.7e-221 736.3 0.0 1.1 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, N-terminal Ceramidse_alk_C PF17048.5 EXF82053.1 - 3.4e-37 127.9 0.1 7e-37 126.9 0.1 1.5 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, C-terminal HET PF06985.11 EXF82053.1 - 7.7e-24 84.7 0.0 1.4e-23 83.8 0.0 1.5 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) G_glu_transpept PF01019.21 EXF82055.1 - 8.4e-168 559.3 0.1 1e-167 559.1 0.1 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase Methyltransf_2 PF00891.18 EXF82056.1 - 3.6e-17 62.4 0.0 8e-17 61.2 0.0 1.5 1 1 0 1 1 1 1 O-methyltransferase domain Methyltransf_PK PF05891.12 EXF82056.1 - 8.4e-06 25.5 0.0 1.5e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_31 PF13847.6 EXF82056.1 - 0.019 14.8 0.0 0.031 14.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_33 PF10017.9 EXF82056.1 - 0.031 13.4 0.0 0.11 11.7 0.0 1.8 2 0 0 2 2 2 0 Histidine-specific methyltransferase, SAM-dependent Methyltransf_23 PF13489.6 EXF82056.1 - 0.049 13.5 0.0 0.1 12.4 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.6 EXF82056.1 - 0.07 13.9 0.0 0.17 12.6 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain DREV PF05219.12 EXF82056.1 - 0.12 11.5 0.0 0.24 10.5 0.0 1.4 1 0 0 1 1 1 0 DREV methyltransferase FeoC PF09012.10 EXF82056.1 - 0.15 12.2 0.0 0.33 11.1 0.0 1.5 1 0 0 1 1 1 0 FeoC like transcriptional regulator adh_short_C2 PF13561.6 EXF82057.1 - 3.2e-56 190.5 0.6 3.8e-56 190.3 0.6 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF82057.1 - 2.8e-47 160.7 0.0 3.4e-47 160.5 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EXF82057.1 - 6.1e-13 49.1 0.1 8.5e-13 48.6 0.1 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EXF82057.1 - 0.0055 16.2 0.1 0.009 15.5 0.1 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family THF_DHG_CYH_C PF02882.19 EXF82057.1 - 0.022 14.1 0.2 0.15 11.4 0.0 2.0 1 1 1 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Pyr_redox PF00070.27 EXF82057.1 - 0.023 15.2 0.1 0.046 14.3 0.1 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.16 EXF82057.1 - 0.1 12.2 0.2 0.32 10.6 0.2 1.9 1 1 0 1 1 1 0 Ketopantoate reductase PanE/ApbA MBOAT_2 PF13813.6 EXF82058.1 - 4e-10 39.8 1.6 4e-10 39.8 1.6 2.9 4 0 0 4 4 4 1 Membrane bound O-acyl transferase family FAD_binding_4 PF01565.23 EXF82059.1 - 3.2e-20 72.3 1.8 6.1e-20 71.4 1.8 1.5 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EXF82059.1 - 1.9e-08 34.2 0.1 4.3e-08 33.1 0.1 1.6 1 0 0 1 1 1 1 Berberine and berberine like Tyrosinase PF00264.20 EXF82062.1 - 2.3e-37 129.5 0.0 2.9e-37 129.1 0.0 1.1 1 0 0 1 1 1 1 Common central domain of tyrosinase DAO PF01266.24 EXF82064.1 - 1.5e-07 31.4 1.5 0.0042 16.7 0.3 2.2 1 1 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EXF82064.1 - 2.4e-06 27.0 0.1 0.00036 19.9 0.1 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EXF82064.1 - 2.8e-06 26.7 1.1 1.3e-05 24.5 1.6 1.7 2 0 0 2 2 2 1 FAD binding domain HI0933_like PF03486.14 EXF82064.1 - 8.1e-06 24.8 0.2 0.0016 17.3 0.5 2.1 2 0 0 2 2 2 2 HI0933-like protein FAD_binding_3 PF01494.19 EXF82064.1 - 1.9e-05 24.1 6.0 0.034 13.4 0.7 2.8 2 1 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 EXF82064.1 - 2.1e-05 24.6 0.0 6e-05 23.2 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 EXF82064.1 - 0.00018 20.9 0.0 0.00029 20.2 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EXF82064.1 - 0.00096 18.6 0.5 0.0015 18.0 0.5 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.22 EXF82064.1 - 0.0053 15.9 0.3 0.008 15.3 0.3 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A AlaDh_PNT_C PF01262.21 EXF82064.1 - 0.0053 16.1 0.0 0.0086 15.4 0.0 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox PF00070.27 EXF82064.1 - 0.028 15.0 0.4 0.12 12.9 0.8 1.8 2 0 0 2 2 1 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EXF82064.1 - 0.055 12.5 0.3 1.4 7.8 0.2 2.2 2 0 0 2 2 2 0 Lycopene cyclase protein 3HCDH_N PF02737.18 EXF82064.1 - 0.14 12.0 0.0 0.23 11.3 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Thi4 PF01946.17 EXF82064.1 - 0.2 10.9 0.1 0.35 10.1 0.1 1.3 1 0 0 1 1 1 0 Thi4 family Fungal_trans_2 PF11951.8 EXF82065.1 - 3.8e-13 49.0 0.9 8.6e-12 44.5 0.1 2.1 1 1 1 2 2 2 2 Fungal specific transcription factor domain Abhydrolase_6 PF12697.7 EXF82066.1 - 2.5e-09 38.1 0.7 3.3e-09 37.7 0.7 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family DLH PF01738.18 EXF82066.1 - 1e-08 35.0 0.1 5.2e-08 32.7 0.1 2.1 2 1 0 2 2 2 1 Dienelactone hydrolase family Abhydrolase_1 PF00561.20 EXF82066.1 - 6.5e-08 32.5 0.5 2.4e-07 30.7 0.2 1.8 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EXF82066.1 - 5.1e-07 29.2 0.3 9.4e-07 28.3 0.3 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Peptidase_S15 PF02129.18 EXF82066.1 - 2e-05 24.3 0.3 5.1e-05 23.0 0.2 1.7 2 0 0 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) AXE1 PF05448.12 EXF82066.1 - 6.9e-05 21.7 0.2 0.00012 20.9 0.2 1.4 1 0 0 1 1 1 1 Acetyl xylan esterase (AXE1) BAAT_C PF08840.11 EXF82066.1 - 7.5e-05 22.8 0.0 0.00016 21.7 0.0 1.6 1 0 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal Peptidase_S9 PF00326.21 EXF82066.1 - 0.0052 16.3 0.1 0.011 15.2 0.1 1.7 2 0 0 2 2 2 1 Prolyl oligopeptidase family adh_short PF00106.25 EXF82067.1 - 2.8e-27 95.5 0.0 6.2e-26 91.1 0.0 2.1 1 1 1 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF82067.1 - 4.9e-16 59.0 0.0 7e-16 58.5 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF82067.1 - 2.7e-06 27.4 0.0 4.3e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EXF82067.1 - 6.6e-05 22.5 0.0 8.8e-05 22.1 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EXF82067.1 - 0.00014 21.9 0.0 0.00018 21.5 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding DUF1776 PF08643.10 EXF82067.1 - 0.00017 21.0 0.0 0.00023 20.6 0.0 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) NmrA PF05368.13 EXF82067.1 - 0.00099 18.7 0.1 0.0016 18.1 0.1 1.4 1 0 0 1 1 1 1 NmrA-like family ADH_zinc_N PF00107.26 EXF82067.1 - 0.021 14.8 0.3 0.68 9.9 0.2 2.3 2 0 0 2 2 2 0 Zinc-binding dehydrogenase CDH-cyt PF16010.5 EXF82068.1 - 1e-49 168.7 0.0 1.3e-49 168.4 0.0 1.1 1 0 0 1 1 1 1 Cytochrome domain of cellobiose dehydrogenase Flavoprotein PF02441.19 EXF82070.1 - 2.2e-18 66.5 0.0 3.6e-18 65.8 0.0 1.3 1 0 0 1 1 1 1 Flavoprotein Ank_4 PF13637.6 EXF82070.1 - 0.017 15.7 0.0 0.16 12.6 0.0 2.7 3 1 0 3 3 3 0 Ankyrin repeats (many copies) Flavodoxin_2 PF02525.17 EXF82070.1 - 0.13 12.0 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 Flavodoxin-like fold Ank_2 PF12796.7 EXF82073.1 - 1.2e-17 64.2 0.1 6.6e-08 33.0 0.0 4.1 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EXF82073.1 - 1.7e-17 63.3 0.5 8.7e-07 29.1 0.2 3.7 3 0 0 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 EXF82073.1 - 3.3e-16 58.9 2.8 0.012 16.1 0.0 6.1 5 0 0 5 5 5 4 Ankyrin repeat Ank_4 PF13637.6 EXF82073.1 - 6e-15 55.4 0.1 0.052 14.1 0.0 6.3 5 2 3 8 8 8 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EXF82073.1 - 1.5e-12 46.5 0.1 0.017 15.6 0.0 6.1 5 0 0 5 5 5 3 Ankyrin repeat TsaE PF02367.17 EXF82074.1 - 0.0043 17.1 0.0 0.0072 16.3 0.0 1.3 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 EXF82074.1 - 0.027 14.4 0.0 0.077 12.9 0.0 1.8 2 0 0 2 2 2 0 NACHT domain MFS_1 PF07690.16 EXF82075.1 - 6e-31 107.7 35.4 6e-31 107.7 35.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF82075.1 - 0.0022 17.0 18.8 0.0022 17.0 18.8 2.1 2 0 0 2 2 2 1 Sugar (and other) transporter Fungal_trans PF04082.18 EXF82076.1 - 3e-25 88.7 0.3 5.6e-25 87.9 0.1 1.5 2 0 0 2 2 2 1 Fungal specific transcription factor domain SNF PF00209.18 EXF82078.1 - 2.3e-89 300.5 31.5 1.6e-88 297.7 31.5 1.9 1 1 0 1 1 1 1 Sodium:neurotransmitter symporter family Aldo_ket_red PF00248.21 EXF82079.1 - 1.3e-47 162.4 0.0 1.5e-47 162.2 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family OPT PF03169.15 EXF82081.1 - 3e-164 548.1 56.9 3.4e-164 547.9 56.9 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein ADH_zinc_N PF00107.26 EXF82082.1 - 2e-15 56.9 0.0 3.4e-15 56.2 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EXF82082.1 - 7e-08 33.6 0.0 9.9e-08 33.1 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EXF82082.1 - 4.5e-06 26.5 0.5 1.2e-05 25.1 0.3 1.8 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain GxGYxYP_C PF14323.6 EXF82083.1 - 3.2e-58 197.4 0.0 6.7e-58 196.4 0.0 1.5 1 0 0 1 1 1 1 GxGYxYP putative glycoside hydrolase C-terminal domain GxGYxYP_N PF16216.5 EXF82083.1 - 5.1e-42 144.5 0.1 8.2e-26 91.5 0.1 2.2 2 0 0 2 2 2 2 GxGYxY sequence motif in domain of unknown function N-terminal PRIMA1 PF16101.5 EXF82083.1 - 0.22 11.6 0.8 0.42 10.7 0.8 1.4 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 PHO4 PF01384.20 EXF82084.1 - 6.4e-114 380.5 17.6 7.4e-114 380.3 17.6 1.0 1 0 0 1 1 1 1 Phosphate transporter family NAD_binding_10 PF13460.6 EXF82085.1 - 1.6e-15 57.5 0.0 2.3e-15 57.0 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EXF82085.1 - 1.3e-14 54.3 0.0 2.1e-14 53.7 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family GFO_IDH_MocA PF01408.22 EXF82085.1 - 0.00019 22.2 0.1 0.00035 21.4 0.1 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold DapB_N PF01113.20 EXF82085.1 - 0.00046 20.3 0.0 0.00079 19.5 0.0 1.3 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Epimerase PF01370.21 EXF82085.1 - 0.0038 16.7 0.0 0.0079 15.7 0.0 1.6 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.24 EXF82085.1 - 0.015 15.7 0.0 0.057 13.9 0.0 1.9 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain NAD_binding_4 PF07993.12 EXF82085.1 - 0.05 12.8 0.0 0.08 12.1 0.0 1.3 1 0 0 1 1 1 0 Male sterility protein RmlD_sub_bind PF04321.17 EXF82085.1 - 0.07 12.2 0.0 0.1 11.6 0.0 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain DUF807 PF05660.11 EXF82085.1 - 0.099 12.6 0.0 0.14 12.1 0.0 1.2 1 0 0 1 1 1 0 Coxiella burnetii protein of unknown function (DUF807) Sugar_tr PF00083.24 EXF82086.1 - 6.3e-98 328.6 20.5 7.7e-98 328.3 20.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF82086.1 - 2.2e-30 105.8 58.3 1.5e-25 89.9 26.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily LacY_symp PF01306.19 EXF82086.1 - 0.0037 16.1 0.1 0.0037 16.1 0.1 3.3 4 0 0 4 4 4 1 LacY proton/sugar symporter OATP PF03137.20 EXF82086.1 - 0.0048 15.2 12.7 0.0094 14.3 0.5 3.0 1 1 2 4 4 4 2 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.16 EXF82087.1 - 8.6e-14 51.2 31.4 7.7e-13 48.1 26.5 3.4 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2975 PF11188.8 EXF82087.1 - 0.24 11.3 0.1 0.24 11.3 0.1 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2975) p450 PF00067.22 EXF82088.1 - 9.7e-52 176.2 0.0 2.5e-31 109.0 0.0 2.0 2 0 0 2 2 2 2 Cytochrome P450 DUF2235 PF09994.9 EXF82089.1 - 2.6e-78 263.3 1.2 1.9e-77 260.4 1.2 2.1 1 1 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) Ribonuclease PF00545.20 EXF82090.1 - 4.2e-08 33.8 0.0 6.8e-08 33.2 0.0 1.3 1 0 0 1 1 1 1 ribonuclease Cytomega_UL20A PF05984.12 EXF82090.1 - 0.093 13.0 0.2 0.15 12.4 0.2 1.3 1 0 0 1 1 1 0 Cytomegalovirus UL20A protein NmrA PF05368.13 EXF82091.1 - 5e-33 114.6 0.0 6.5e-32 110.9 0.0 1.9 1 1 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EXF82091.1 - 8.8e-08 32.2 0.1 1.2e-07 31.8 0.1 1.2 1 0 0 1 1 1 1 NAD(P)H-binding DapB_N PF01113.20 EXF82091.1 - 0.053 13.7 0.0 0.088 12.9 0.0 1.3 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Hira PF07569.11 EXF82092.1 - 5.2e-85 284.7 0.0 1.4e-84 283.3 0.0 1.8 2 0 0 2 2 2 1 TUP1-like enhancer of split WD40 PF00400.32 EXF82092.1 - 2.1e-29 101.1 22.2 4.9e-05 24.0 0.0 8.2 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EXF82092.1 - 6.5e-13 48.8 0.0 0.16 12.3 0.0 6.0 5 1 1 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain HIRA_B PF09453.10 EXF82092.1 - 7.4e-10 38.4 0.4 2e-09 37.0 0.4 1.8 1 0 0 1 1 1 1 HIRA B motif PD40 PF07676.12 EXF82092.1 - 2e-05 24.4 0.6 5.5 7.0 0.3 4.6 4 0 0 4 4 4 3 WD40-like Beta Propeller Repeat Ge1_WD40 PF16529.5 EXF82092.1 - 6e-05 22.2 3.0 0.76 8.7 0.2 4.7 2 2 3 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein IKI3 PF04762.12 EXF82092.1 - 0.011 13.8 0.0 0.067 11.2 0.0 2.1 3 0 0 3 3 3 0 IKI3 family DUF5541 PF17695.1 EXF82093.1 - 0.0059 17.0 0.0 0.015 15.7 0.0 1.6 1 0 0 1 1 1 1 Family of unknown function (DUF5541) Lebercilin PF15619.6 EXF82096.1 - 0.0006 19.5 15.2 0.0006 19.5 15.2 5.5 2 2 3 5 5 5 1 Ciliary protein causing Leber congenital amaurosis disease SHE3 PF17078.5 EXF82096.1 - 0.00096 18.9 9.1 0.00096 18.9 9.1 4.6 1 1 3 4 4 4 1 SWI5-dependent HO expression protein 3 Spc7 PF08317.11 EXF82096.1 - 0.0077 15.1 76.9 0.0069 15.3 12.7 4.7 2 1 2 4 4 4 2 Spc7 kinetochore protein DUF1664 PF07889.12 EXF82096.1 - 0.12 12.4 38.9 0.098 12.7 1.9 6.7 2 2 4 7 7 7 0 Protein of unknown function (DUF1664) FUSC PF04632.12 EXF82096.1 - 6.3 5.2 21.3 0.32 9.5 6.1 2.9 2 2 0 2 2 2 0 Fusaric acid resistance protein family ArAE_2_N PF10337.9 EXF82097.1 - 1.8e-36 126.2 2.5 1.8e-36 126.2 2.5 3.8 2 2 1 3 3 3 1 Putative ER transporter, 6TM, N-terminal FUSC_2 PF13515.6 EXF82097.1 - 1.8e-18 66.9 17.5 1.8e-18 66.9 17.5 3.0 2 2 0 2 2 2 1 Fusaric acid resistance protein-like ArAE_2 PF10334.9 EXF82097.1 - 2.6e-06 27.5 1.2 1.1e-05 25.4 0.2 2.3 2 1 0 2 2 2 1 Aromatic acid exporter family member 2 HET PF06985.11 EXF82098.1 - 1.8e-17 64.1 1.0 1.6e-14 54.4 0.0 2.3 2 0 0 2 2 2 2 Heterokaryon incompatibility protein (HET) DUF3295 PF11702.8 EXF82098.1 - 0.73 9.1 3.6 1.1 8.5 3.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) Velvet PF11754.8 EXF82099.1 - 4.7e-39 134.8 9.5 8.8e-29 101.2 0.1 3.1 2 1 1 3 3 3 3 Velvet factor BBE PF08031.12 EXF82100.1 - 2e-09 37.4 0.0 4.2e-09 36.4 0.0 1.5 1 0 0 1 1 1 1 Berberine and berberine like FAD_binding_4 PF01565.23 EXF82100.1 - 4.3e-09 36.2 0.1 9.1e-09 35.2 0.1 1.5 1 0 0 1 1 1 1 FAD binding domain SnoaL_3 PF13474.6 EXF82101.1 - 1.7e-06 28.3 0.0 3.3e-06 27.4 0.0 1.5 1 0 0 1 1 1 1 SnoaL-like domain DUF4440 PF14534.6 EXF82101.1 - 0.024 15.0 0.6 0.05 14.0 0.3 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4440) TCP PF03634.13 EXF82101.1 - 0.15 12.6 0.0 0.2 12.2 0.0 1.4 1 0 0 1 1 1 0 TCP family transcription factor Pyr_redox_2 PF07992.14 EXF82102.1 - 4.2e-15 55.8 0.0 4.2e-12 45.9 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EXF82102.1 - 4.7e-14 52.3 0.0 2.7e-12 46.6 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 EXF82102.1 - 1.5e-13 50.0 0.0 3.2e-13 49.0 0.0 1.4 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like K_oxygenase PF13434.6 EXF82102.1 - 6e-13 48.6 0.0 2.4e-11 43.4 0.0 2.2 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 EXF82102.1 - 4.3e-08 33.3 0.0 3.2e-07 30.5 0.0 2.4 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 EXF82102.1 - 9.1e-07 29.0 0.1 0.019 14.9 0.0 4.1 3 1 0 3 3 3 1 FAD-NAD(P)-binding DAO PF01266.24 EXF82102.1 - 1.6e-06 28.0 0.5 0.022 14.4 0.1 3.2 2 1 1 3 3 3 2 FAD dependent oxidoreductase GIDA PF01134.22 EXF82102.1 - 0.0015 17.7 0.2 0.59 9.2 0.1 2.5 3 0 0 3 3 3 2 Glucose inhibited division protein A NAD_binding_7 PF13241.6 EXF82102.1 - 0.0026 18.2 0.0 0.34 11.4 0.0 2.8 2 1 0 2 2 2 1 Putative NAD(P)-binding Lycopene_cycl PF05834.12 EXF82102.1 - 0.0095 15.0 0.0 0.043 12.9 0.0 2.1 2 1 0 2 2 2 1 Lycopene cyclase protein Thi4 PF01946.17 EXF82102.1 - 0.012 14.8 0.0 1.2 8.3 0.0 2.4 2 0 0 2 2 2 0 Thi4 family FAD_binding_2 PF00890.24 EXF82102.1 - 0.027 13.6 0.1 0.057 12.5 0.1 1.5 1 0 0 1 1 1 0 FAD binding domain Shikimate_DH PF01488.20 EXF82102.1 - 0.032 14.3 0.0 0.48 10.5 0.0 2.4 3 0 0 3 3 3 0 Shikimate / quinate 5-dehydrogenase Pyr_redox PF00070.27 EXF82102.1 - 0.041 14.4 0.0 11 6.7 0.1 2.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EXF82102.1 - 0.051 12.8 0.0 0.27 10.4 0.0 2.2 3 0 0 3 3 3 0 FAD binding domain HI0933_like PF03486.14 EXF82102.1 - 0.057 12.1 0.1 0.14 10.9 0.1 1.6 1 0 0 1 1 1 0 HI0933-like protein FAD_oxidored PF12831.7 EXF82102.1 - 0.083 12.2 0.0 2.2 7.6 0.0 2.3 2 0 0 2 2 2 0 FAD dependent oxidoreductase p450 PF00067.22 EXF82103.1 - 8.4e-72 242.4 0.0 9.9e-72 242.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 SF3a60_bindingd PF12108.8 EXF82103.1 - 0.17 11.8 0.3 0.36 10.7 0.3 1.6 1 0 0 1 1 1 0 Splicing factor SF3a60 binding domain Peptidase_S8 PF00082.22 EXF82105.1 - 1.8e-37 129.2 2.4 3.7e-37 128.2 2.4 1.5 1 0 0 1 1 1 1 Subtilase family fn3_5 PF06280.12 EXF82105.1 - 1.5e-09 38.5 2.1 1.5e-09 38.5 2.1 1.8 2 0 0 2 2 2 1 Fn3-like domain FlgD_ig PF13860.6 EXF82105.1 - 0.00085 19.1 3.6 0.0009 19.1 0.1 2.8 3 0 0 3 3 3 1 FlgD Ig-like domain fn3_6 PF17766.1 EXF82105.1 - 0.01 16.0 1.3 0.18 12.0 0.3 2.7 2 0 0 2 2 2 0 Fibronectin type-III domain adh_short PF00106.25 EXF82106.1 - 7.7e-31 107.1 0.0 1.2e-28 99.9 0.0 2.9 2 1 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF82106.1 - 4.8e-26 91.8 0.0 6.4e-24 84.8 0.0 2.1 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase zf-C3HC PF07967.13 EXF82106.1 - 0.23 11.5 0.0 0.4 10.7 0.0 1.3 1 0 0 1 1 1 0 C3HC zinc finger-like Zn_clus PF00172.18 EXF82107.1 - 1.1e-05 25.4 8.7 2.3e-05 24.4 8.7 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EXF82107.1 - 0.00012 21.2 0.4 0.0012 17.9 0.0 2.1 1 1 1 2 2 2 1 Fungal specific transcription factor domain MFS_1 PF07690.16 EXF82108.1 - 8.8e-36 123.6 75.1 7.1e-28 97.5 43.1 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF82108.1 - 8.3e-13 48.0 29.2 2.5e-07 29.9 11.2 2.7 2 1 1 3 3 3 2 Sugar (and other) transporter MFS_2 PF13347.6 EXF82108.1 - 0.039 12.5 24.6 0.033 12.8 19.7 2.2 1 1 1 2 2 2 0 MFS/sugar transport protein DUF1996 PF09362.10 EXF82109.1 - 1.3e-43 149.7 0.2 1.5e-43 149.4 0.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1996) Lipase_GDSL_2 PF13472.6 EXF82110.1 - 5.3e-10 40.0 1.4 9.4e-10 39.2 0.4 1.9 2 0 0 2 2 2 1 GDSL-like Lipase/Acylhydrolase family PSII_BNR PF14870.6 EXF82110.1 - 6.4e-08 32.2 7.4 3.9e-05 23.1 0.2 3.6 3 1 1 4 4 4 2 Photosynthesis system II assembly factor YCF48 Sortilin-Vps10 PF15902.5 EXF82110.1 - 1.7e-06 27.1 0.2 2.8e-05 23.1 0.0 2.3 2 1 0 2 2 2 1 Sortilin, neurotensin receptor 3, BNR PF02012.20 EXF82110.1 - 5.9e-06 25.5 24.1 0.76 10.0 0.7 6.5 5 1 0 5 5 5 4 BNR/Asp-box repeat Lipase_GDSL PF00657.22 EXF82110.1 - 0.0052 16.8 0.1 0.013 15.5 0.1 1.7 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase BNR_2 PF13088.6 EXF82110.1 - 0.028 13.7 1.1 7.7 5.7 0.1 3.5 3 1 0 3 3 3 0 BNR repeat-like domain p450 PF00067.22 EXF82111.1 - 8.8e-25 87.4 0.0 1.1e-24 87.0 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 Arrestin_N PF00339.29 EXF82112.1 - 2e-07 31.1 0.3 6.9e-07 29.4 0.3 1.9 1 1 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 EXF82112.1 - 3.1e-05 24.5 0.4 0.024 15.1 0.0 2.6 2 1 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Bul1_C PF04426.12 EXF82112.1 - 0.0059 16.1 0.1 0.011 15.1 0.1 1.4 1 0 0 1 1 1 1 Bul1 C terminus ECH_1 PF00378.20 EXF82113.1 - 1.1e-38 133.1 0.2 5.8e-38 130.6 0.2 1.9 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EXF82113.1 - 2.8e-18 66.5 0.0 5.4e-18 65.6 0.0 1.5 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Peptidase_S49 PF01343.18 EXF82113.1 - 0.1 12.6 0.1 2.7 7.9 0.0 2.1 2 0 0 2 2 2 0 Peptidase family S49 NAD_binding_2 PF03446.15 EXF82114.1 - 5.3e-31 107.9 0.0 1.1e-30 106.9 0.0 1.5 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 EXF82114.1 - 5.5e-16 58.9 0.2 9.7e-16 58.1 0.2 1.4 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase F420_oxidored PF03807.17 EXF82114.1 - 0.026 15.1 0.0 0.056 14.0 0.0 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Homeobox_KN PF05920.11 EXF82115.1 - 2.4e-13 49.7 2.9 6.1e-13 48.4 2.9 1.8 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 EXF82115.1 - 2.1e-05 24.3 1.0 6.2e-05 22.8 1.0 1.8 1 0 0 1 1 1 1 Homeodomain HTH_Tnp_Tc5 PF03221.16 EXF82115.1 - 2.7e-05 24.1 1.1 0.21 11.6 0.1 3.0 2 1 0 2 2 2 2 Tc5 transposase DNA-binding domain zf-C2H2_4 PF13894.6 EXF82115.1 - 0.0026 18.5 4.1 0.0026 18.5 4.1 4.8 4 0 0 4 4 4 1 C2H2-type zinc finger zf-C2H2 PF00096.26 EXF82115.1 - 0.0046 17.4 23.9 0.0066 16.8 4.3 4.6 4 0 0 4 4 4 2 Zinc finger, C2H2 type zf-C2H2_2 PF12756.7 EXF82115.1 - 6 7.3 12.3 23 5.4 0.8 3.5 2 1 0 3 3 3 0 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.8 EXF82115.1 - 6.9 7.1 9.3 1 9.7 3.3 2.6 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding MFS_1 PF07690.16 EXF82116.1 - 1.6e-24 86.5 38.5 1.6e-24 86.5 38.5 2.9 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 EXF82116.1 - 0.00066 18.1 3.1 0.0013 17.1 3.1 1.5 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.16 EXF82117.1 - 6.6e-35 120.7 30.1 6.6e-35 120.7 30.1 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily GFA PF04828.14 EXF82118.1 - 1.1e-12 48.2 2.0 3.4e-05 24.1 0.0 3.3 3 0 0 3 3 3 3 Glutathione-dependent formaldehyde-activating enzyme NOB1_Zn_bind PF08772.11 EXF82118.1 - 1.2 9.4 8.3 0.95 9.7 0.1 3.0 3 0 0 3 3 3 0 Nin one binding (NOB1) Zn-ribbon like peroxidase PF00141.23 EXF82119.1 - 7.8e-82 274.4 0.2 9.3e-45 153.1 0.0 2.2 2 0 0 2 2 2 2 Peroxidase MFS_1 PF07690.16 EXF82120.1 - 3.7e-48 164.3 54.8 5.3e-48 163.7 53.1 2.2 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EXF82120.1 - 2.2e-18 66.1 19.1 6.1e-18 64.6 19.1 1.7 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EXF82120.1 - 5.7e-13 48.5 6.7 5.7e-13 48.5 6.7 3.4 2 1 0 3 3 3 1 Sugar (and other) transporter MFS_2 PF13347.6 EXF82120.1 - 2e-06 26.6 5.9 2e-06 26.6 5.9 3.1 2 1 0 2 2 2 1 MFS/sugar transport protein CbtB PF09489.10 EXF82120.1 - 8.9 6.5 6.5 6.8 6.9 0.3 3.8 3 0 0 3 3 3 0 Probable cobalt transporter subunit (CbtB) adh_short PF00106.25 EXF82121.1 - 1.1e-25 90.3 0.6 1.2e-21 77.1 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EXF82121.1 - 5.8e-15 55.5 0.2 2e-13 50.5 0.2 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF82121.1 - 6.3e-11 42.5 0.0 9.8e-11 41.9 0.0 1.4 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EXF82121.1 - 1e-06 28.4 0.0 1.5e-06 27.9 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Sacchrp_dh_NADP PF03435.18 EXF82121.1 - 0.0014 18.9 0.0 0.0026 18.0 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 EXF82121.1 - 0.0037 17.3 0.0 0.0073 16.4 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Polysacc_synt_2 PF02719.15 EXF82121.1 - 0.0039 16.4 0.0 0.005 16.0 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Semialdhyde_dh PF01118.24 EXF82121.1 - 0.018 15.5 0.0 0.05 14.0 0.0 1.7 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain SPO22 PF08631.10 EXF82121.1 - 0.11 11.9 0.0 0.17 11.3 0.0 1.2 1 0 0 1 1 1 0 Meiosis protein SPO22/ZIP4 like DUF3425 PF11905.8 EXF82122.1 - 1.4e-24 86.4 0.0 2.3e-24 85.7 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) Acetyltransf_1 PF00583.25 EXF82123.1 - 2.8e-16 59.8 0.0 3.7e-16 59.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EXF82123.1 - 1.2e-10 41.6 0.0 1.8e-10 41.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EXF82123.1 - 3.8e-09 36.6 0.0 5.1e-09 36.2 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 EXF82123.1 - 7.3e-07 29.9 0.0 1e-06 29.5 0.0 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 EXF82123.1 - 0.00037 20.7 0.0 0.00041 20.5 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EXF82123.1 - 0.0072 16.4 0.0 0.014 15.5 0.0 1.5 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase FR47 PF08445.10 EXF82123.1 - 0.019 14.9 0.1 0.065 13.2 0.1 1.9 1 1 1 2 2 2 0 FR47-like protein Ank_2 PF12796.7 EXF82126.1 - 3.9e-18 65.8 0.1 1.9e-05 25.2 0.0 4.2 3 2 2 5 5 5 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EXF82126.1 - 9.3e-15 54.8 5.3 0.00016 22.2 0.1 5.8 5 2 1 6 6 6 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EXF82126.1 - 2.1e-11 43.0 1.4 0.38 11.5 0.0 7.0 7 1 0 7 7 7 3 Ankyrin repeat Ank_5 PF13857.6 EXF82126.1 - 4e-07 30.2 3.2 0.076 13.4 0.1 4.7 3 2 1 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 EXF82126.1 - 3.6e-05 24.0 1.9 5.7 7.6 0.1 5.8 6 0 0 6 6 6 1 Ankyrin repeat F-box PF00646.33 EXF82126.1 - 8.9e-05 22.3 0.2 0.00023 20.9 0.2 1.7 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EXF82126.1 - 0.068 13.1 0.2 0.16 11.9 0.2 1.7 1 0 0 1 1 1 0 F-box-like Glyco_transf_15 PF01793.16 EXF82127.1 - 2.6e-59 201.1 0.6 6e-39 134.2 0.4 3.0 2 1 0 2 2 2 2 Glycolipid 2-alpha-mannosyltransferase DUF1348 PF07080.11 EXF82128.1 - 0.0041 17.0 0.0 0.0062 16.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1348) SnoaL_2 PF12680.7 EXF82128.1 - 0.071 13.8 0.0 0.13 12.9 0.0 1.5 1 0 0 1 1 1 0 SnoaL-like domain SSURE PF11966.8 EXF82129.1 - 0.041 13.6 0.0 0.079 12.7 0.0 1.4 1 0 0 1 1 1 0 Fibronectin-binding repeat Acetyltransf_1 PF00583.25 EXF82130.1 - 2.9e-09 37.2 0.0 3.7e-09 36.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EXF82130.1 - 8.6e-07 29.0 0.0 1.2e-06 28.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EXF82130.1 - 1.2e-05 25.7 0.0 1.7e-05 25.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EXF82130.1 - 0.0038 17.2 0.0 0.006 16.5 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein FtsJ PF01728.19 EXF82131.1 - 2.7e-62 210.0 0.0 3.5e-62 209.7 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase DEAD PF00270.29 EXF82132.1 - 1.3e-45 155.3 0.0 3.6e-44 150.6 0.0 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EXF82132.1 - 4.9e-26 91.3 0.1 1.3e-25 89.9 0.1 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Zip PF02535.22 EXF82132.1 - 0.53 9.4 1.7 0.92 8.7 1.7 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter Ndc1_Nup PF09531.10 EXF82132.1 - 7.4 5.1 8.2 12 4.4 8.2 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup GREB1 PF15782.5 EXF82132.1 - 8.7 3.3 7.0 12 2.8 7.0 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer CRCB PF02537.15 EXF82134.1 - 0.19 12.1 4.5 0.48 10.8 4.5 1.7 1 0 0 1 1 1 0 CrcB-like protein, Camphor Resistance (CrcB) COesterase PF00135.28 EXF82135.1 - 2.7e-86 290.5 0.0 3.9e-86 290.0 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EXF82135.1 - 0.0078 16.1 0.3 0.26 11.1 0.0 2.3 2 0 0 2 2 2 1 alpha/beta hydrolase fold FXR_C1 PF16096.5 EXF82136.1 - 7.3 6.9 9.2 0.14 12.4 0.8 2.4 2 1 0 2 2 2 0 Fragile X-related 1 protein C-terminal region 2 Syndecan PF01034.20 EXF82137.1 - 1.5e-06 28.0 0.0 3.3e-06 26.9 0.0 1.5 1 0 0 1 1 1 1 Syndecan domain DUF4342 PF14242.6 EXF82137.1 - 0.21 11.6 0.8 0.39 10.7 0.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4342) FeoB_associated PF12669.7 EXF82137.1 - 0.29 11.6 2.4 1 9.8 2.4 1.9 1 1 0 1 1 1 0 FeoB-associated Cys-rich membrane protein TPR_MLP1_2 PF07926.12 EXF82138.1 - 8e-40 135.9 50.9 1.7e-39 134.9 31.1 19.3 8 5 13 21 21 21 7 TPR/MLP1/MLP2-like protein ZapB PF06005.12 EXF82138.1 - 0.0032 17.9 6.5 0.0032 17.9 6.5 26.3 14 8 2 18 18 18 2 Cell division protein ZapB IFT20 PF14931.6 EXF82138.1 - 0.0044 17.2 13.1 0.0044 17.2 13.1 17.3 10 6 5 17 17 17 2 Intraflagellar transport complex B, subunit 20 FlaC_arch PF05377.11 EXF82138.1 - 0.017 15.5 0.9 0.017 15.5 0.9 21.8 20 4 3 24 24 24 0 Flagella accessory protein C (FlaC) DUF3693 PF12472.8 EXF82138.1 - 0.072 12.7 0.5 0.37 10.5 0.5 2.2 1 0 0 1 1 1 0 Phage related protein HTH_Tnp_ISL3 PF13542.6 EXF82138.1 - 0.22 10.9 0.8 7.8 6.0 0.2 2.8 2 0 0 2 2 2 0 Helix-turn-helix domain of transposase family ISL3 p450 PF00067.22 EXF82139.1 - 1.2e-41 143.0 0.0 1.5e-41 142.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 adh_short PF00106.25 EXF82140.1 - 7.1e-31 107.2 0.0 1.1e-30 106.6 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF82140.1 - 2.4e-22 79.6 0.0 7.2e-22 78.1 0.0 1.6 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF82140.1 - 0.0018 18.2 0.0 0.0031 17.4 0.0 1.3 1 0 0 1 1 1 1 KR domain Spore_GerAC PF05504.11 EXF82140.1 - 0.07 13.3 0.0 0.11 12.7 0.0 1.3 1 0 0 1 1 1 0 Spore germination B3/ GerAC like, C-terminal UPF0016 PF01169.19 EXF82141.1 - 0.54 10.6 5.5 5.8 7.3 2.0 3.0 2 1 0 2 2 2 0 Uncharacterized protein family UPF0016 FAD_binding_4 PF01565.23 EXF82142.1 - 6.6e-18 64.8 2.0 1.9e-17 63.3 1.8 1.8 2 0 0 2 2 2 1 FAD binding domain CD20 PF04103.15 EXF82142.1 - 2 8.5 5.3 7.8 6.6 1.8 2.3 2 0 0 2 2 2 0 CD20-like family MFS_1 PF07690.16 EXF82143.1 - 8.8e-36 123.5 16.8 8.8e-36 123.5 16.8 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 EXF82143.1 - 1.4e-05 24.6 4.3 1.4e-05 24.6 4.3 2.2 2 0 0 2 2 2 2 Uncharacterised MFS-type transporter YbfB Neurensin PF14927.6 EXF82143.1 - 0.28 10.9 2.0 0.49 10.1 0.4 2.2 2 0 0 2 2 2 0 Neurensin Cu-oxidase_2 PF07731.14 EXF82144.1 - 2.8e-38 130.8 5.2 2.8e-38 130.8 5.2 2.6 2 1 0 2 2 2 1 Multicopper oxidase Cu-oxidase_3 PF07732.15 EXF82144.1 - 7.8e-38 129.1 2.7 7.8e-38 129.1 2.7 2.9 4 0 0 4 4 4 1 Multicopper oxidase Cu-oxidase PF00394.22 EXF82144.1 - 2.9e-35 121.7 0.5 2.7e-34 118.6 0.1 2.4 2 0 0 2 2 2 1 Multicopper oxidase Cation_ATPase_C PF00689.21 EXF82146.1 - 1.1e-45 155.6 5.9 1.1e-45 155.6 5.9 2.0 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 EXF82146.1 - 2.3e-35 121.7 0.3 2.3e-35 121.7 0.3 2.4 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase PF13246.6 EXF82146.1 - 7.6e-22 77.2 0.0 1.4e-21 76.4 0.0 1.4 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EXF82146.1 - 3.5e-21 76.4 0.1 9.5e-21 75.0 0.1 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EXF82146.1 - 8.1e-11 41.5 0.0 2.9e-09 36.5 0.0 2.9 3 0 0 3 3 3 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EXF82146.1 - 0.00033 20.5 0.6 0.00083 19.2 0.2 1.8 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Pox_T4_N PF04491.12 EXF82146.1 - 0.096 12.6 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 Poxvirus T4 protein, N terminus DUF21 PF01595.20 EXF82146.1 - 0.17 11.5 3.3 0.23 11.2 0.2 2.8 2 0 0 2 2 2 0 Cyclin M transmembrane N-terminal domain Tim29 PF10171.9 EXF82147.1 - 0.094 12.2 0.0 0.23 11.0 0.0 1.6 1 0 0 1 1 1 0 Translocase of the Inner Mitochondrial membrane 29 HET PF06985.11 EXF82148.1 - 1.1e-25 90.7 0.0 1.8e-25 90.0 0.0 1.3 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) AA_permease PF00324.21 EXF82149.1 - 3.6e-103 345.7 36.3 4.3e-103 345.5 36.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EXF82149.1 - 2.6e-32 112.2 41.7 3e-32 112.0 41.7 1.0 1 0 0 1 1 1 1 Amino acid permease NCE101 PF11654.8 EXF82149.1 - 0.15 11.8 0.2 1.3 8.8 0.1 2.4 2 0 0 2 2 2 0 Non-classical export protein 1 DUF1479 PF07350.12 EXF82150.1 - 2.3e-148 494.4 0.0 2.8e-148 494.1 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1479) MFS_1 PF07690.16 EXF82151.1 - 6.9e-16 58.1 41.2 6.9e-16 58.1 41.2 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily Lactamase_B_2 PF12706.7 EXF82152.1 - 6.1e-08 32.4 0.0 1.8e-07 30.9 0.0 1.7 2 0 0 2 2 2 1 Beta-lactamase superfamily domain DRMBL PF07522.14 EXF82152.1 - 5e-06 26.7 0.0 1.4e-05 25.2 0.0 1.8 1 0 0 1 1 1 1 DNA repair metallo-beta-lactamase Lactamase_B PF00753.27 EXF82152.1 - 0.00014 22.0 0.1 0.00059 19.9 0.1 2.1 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily RMMBL PF07521.12 EXF82152.1 - 0.0043 16.9 0.0 0.012 15.5 0.0 1.7 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain MFS_1 PF07690.16 EXF82153.1 - 2.5e-45 155.0 28.4 2.5e-45 155.0 28.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily GCN5L1 PF06320.13 EXF82154.1 - 0.061 13.5 0.3 0.061 13.5 0.3 2.2 2 0 0 2 2 2 0 GCN5-like protein 1 (GCN5L1) Val_tRNA-synt_C PF10458.9 EXF82154.1 - 0.22 11.8 1.6 0.7 10.2 0.7 2.4 2 0 0 2 2 2 0 Valyl tRNA synthetase tRNA binding arm Transcrip_act PF04949.13 EXF82154.1 - 0.41 10.5 5.2 0.34 10.8 0.9 2.3 2 0 0 2 2 2 0 Transcriptional activator CAP59_mtransfer PF11735.8 EXF82156.1 - 5.3e-63 212.9 0.0 6.7e-63 212.6 0.0 1.1 1 0 0 1 1 1 1 Cryptococcal mannosyltransferase 1 CorA PF01544.18 EXF82157.1 - 0.23 10.7 6.3 0.64 9.3 6.3 1.9 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein Rx_N PF18052.1 EXF82157.1 - 1.2 9.5 3.5 8.6 6.7 0.1 2.5 1 1 1 2 2 2 0 Rx N-terminal domain UDPGT PF00201.18 EXF82159.1 - 2.9e-05 23.0 0.0 4.2e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_transf_28 PF03033.20 EXF82159.1 - 0.01 15.9 0.0 0.021 14.9 0.0 1.5 1 0 0 1 1 1 0 Glycosyltransferase family 28 N-terminal domain B12-binding PF02310.19 EXF82159.1 - 0.025 14.6 0.0 0.074 13.1 0.0 1.8 1 0 0 1 1 1 0 B12 binding domain DUF5456 PF17539.2 EXF82159.1 - 0.044 13.6 0.0 0.1 12.5 0.0 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5456) p450 PF00067.22 EXF82160.1 - 3.1e-53 181.2 0.0 9.8e-40 136.7 0.0 2.1 1 1 1 2 2 2 2 Cytochrome P450 Cu-oxidase PF00394.22 EXF82160.1 - 7e-31 107.5 0.2 2.3e-30 105.8 0.1 1.9 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase_3 PF07732.15 EXF82160.1 - 6.7e-29 100.3 0.5 3.2e-28 98.1 0.0 2.4 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 EXF82160.1 - 2.1e-22 79.3 6.8 1.9e-19 69.7 1.8 3.1 2 1 0 2 2 2 2 Multicopper oxidase MFS_1 PF07690.16 EXF82161.1 - 4.3e-32 111.4 27.1 4.3e-32 111.4 27.1 1.7 2 0 0 2 2 2 1 Major Facilitator Superfamily DUF4118 PF13493.6 EXF82161.1 - 0.11 12.4 0.1 0.11 12.4 0.1 3.1 3 1 0 4 4 4 0 Domain of unknown function (DUF4118) Arylsulfotran_2 PF14269.6 EXF82162.1 - 3.5e-58 197.3 0.1 5.3e-58 196.7 0.1 1.2 1 0 0 1 1 1 1 Arylsulfotransferase (ASST) Arylsulfotrans PF05935.11 EXF82162.1 - 5.6e-22 78.2 0.0 3.1e-21 75.7 0.0 1.9 1 1 0 1 1 1 1 Arylsulfotransferase (ASST) BLM10_mid PF16507.5 EXF82164.1 - 9.4e-197 654.8 0.0 1.7e-196 653.9 0.0 1.5 1 0 0 1 1 1 1 Proteasome-substrate-size regulator, mid region DUF3437 PF11919.8 EXF82164.1 - 2.3e-29 101.1 0.0 1.1e-28 99.0 0.0 2.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3437) BLM10_N PF16547.5 EXF82164.1 - 4.5e-22 78.1 0.1 1.4e-21 76.5 0.1 2.0 1 0 0 1 1 1 1 Proteasome-substrate-size regulator, N-terminal Adaptin_N PF01602.20 EXF82164.1 - 0.19 10.2 0.1 20 3.5 0.0 3.0 2 1 0 3 3 3 0 Adaptin N terminal region HEAT PF02985.22 EXF82164.1 - 0.66 10.4 5.9 9.9 6.7 0.1 5.1 5 0 0 5 5 5 0 HEAT repeat Zn_clus PF00172.18 EXF82165.1 - 7.9e-08 32.3 13.9 7.9e-08 32.3 13.9 2.1 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain VCBS PF13517.6 EXF82165.1 - 0.12 12.9 0.1 0.34 11.5 0.1 1.8 1 0 0 1 1 1 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FAD_binding_4 PF01565.23 EXF82166.1 - 7e-19 68.0 1.6 1.1e-18 67.3 1.6 1.3 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EXF82166.1 - 4.7e-07 29.8 0.0 9.9e-07 28.8 0.0 1.4 1 0 0 1 1 1 1 Berberine and berberine like MFS_1 PF07690.16 EXF82167.1 - 1.2e-39 136.3 50.8 1.2e-39 136.3 50.8 1.8 2 1 0 2 2 2 1 Major Facilitator Superfamily Fungal_trans PF04082.18 EXF82168.1 - 3.2e-15 55.9 0.1 1e-14 54.2 0.1 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain IFT43 PF15305.6 EXF82168.1 - 0.099 12.8 0.0 0.21 11.8 0.0 1.4 1 0 0 1 1 1 0 Intraflagellar transport protein 43 Cupin_2 PF07883.11 EXF82169.1 - 4.9e-10 39.0 0.2 7.1e-10 38.5 0.2 1.2 1 0 0 1 1 1 1 Cupin domain Cupin_3 PF05899.12 EXF82169.1 - 0.015 15.0 0.1 0.021 14.5 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF861) Glyco_transf_5 PF08323.11 EXF82171.1 - 9.4e-16 58.2 0.1 2.1e-15 57.1 0.1 1.5 1 0 0 1 1 1 1 Starch synthase catalytic domain Alpha-amylase PF00128.24 EXF82171.1 - 1.9e-13 50.7 1.8 1.9e-13 50.7 1.8 3.0 2 1 0 2 2 2 1 Alpha amylase, catalytic domain Glycos_transf_1 PF00534.20 EXF82171.1 - 9.2e-05 22.0 0.0 0.00018 21.1 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Methyltransf_23 PF13489.6 EXF82172.1 - 2.2e-21 76.4 0.0 4.6e-21 75.4 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF82172.1 - 1.4e-12 48.1 0.0 3.4e-12 46.9 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF82172.1 - 1.6e-11 44.7 0.0 3.6e-11 43.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF82172.1 - 2.5e-11 43.6 0.0 2e-10 40.7 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF82172.1 - 2.9e-11 44.0 0.0 6.7e-11 42.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EXF82172.1 - 1.6e-06 27.6 0.0 5e-06 26.0 0.0 1.7 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family FtsJ PF01728.19 EXF82172.1 - 0.00028 21.0 0.0 0.00045 20.4 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_4 PF02390.17 EXF82172.1 - 0.0011 18.4 0.0 0.0029 17.1 0.0 1.7 2 0 0 2 2 2 1 Putative methyltransferase MTS PF05175.14 EXF82172.1 - 0.21 11.1 0.0 0.53 9.8 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase small domain DAO PF01266.24 EXF82173.1 - 2.3e-46 159.0 0.9 3.1e-46 158.6 0.9 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EXF82173.1 - 0.0046 17.2 0.1 0.015 15.5 0.1 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 EXF82173.1 - 0.0052 16.8 0.1 0.18 11.8 0.1 2.3 2 0 0 2 2 2 1 FAD-NAD(P)-binding MCRA PF06100.11 EXF82173.1 - 0.059 12.2 0.1 0.074 11.8 0.1 1.1 1 0 0 1 1 1 0 MCRA family Pyr_redox_3 PF13738.6 EXF82173.1 - 0.14 11.4 0.0 0.37 10.0 0.0 1.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Dioxygenase_C PF00775.21 EXF82175.1 - 1.9e-06 27.5 0.0 2.8e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 Dioxygenase PBP PF01161.20 EXF82180.1 - 1.4e-16 61.1 0.0 1.8e-16 60.6 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein Galactosyl_T PF01762.21 EXF82181.1 - 2e-14 53.9 1.0 5.9e-14 52.3 1.0 1.7 1 1 0 1 1 1 1 Galactosyltransferase adh_short PF00106.25 EXF82182.1 - 6.5e-23 81.2 0.0 8.6e-23 80.8 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF82182.1 - 1e-14 54.7 0.0 1.3e-14 54.4 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF82182.1 - 4e-10 39.9 0.0 5.5e-10 39.4 0.0 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EXF82182.1 - 7e-05 22.4 0.0 0.00015 21.3 0.0 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Methyltransf_16 PF10294.9 EXF82183.1 - 1.4e-24 86.8 0.0 2.1e-24 86.2 0.0 1.2 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_23 PF13489.6 EXF82183.1 - 0.00026 20.9 0.0 0.00053 19.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF82183.1 - 0.014 16.1 0.0 0.033 14.9 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain dCMP_cyt_deam_1 PF00383.23 EXF82184.1 - 1.6e-07 31.2 0.0 2.3e-07 30.6 0.0 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EXF82184.1 - 2.6e-05 24.0 0.0 6.5e-05 22.7 0.0 1.6 1 1 0 1 1 1 1 MafB19-like deaminase HTH_47 PF16221.5 EXF82184.1 - 0.2 11.2 0.1 2.1 7.9 0.0 2.1 2 0 0 2 2 2 0 winged helix-turn-helix Zeta_toxin PF06414.12 EXF82186.1 - 1.4e-07 31.0 0.0 2e-07 30.5 0.0 1.2 1 0 0 1 1 1 1 Zeta toxin OsmC PF02566.19 EXF82187.1 - 2.2e-16 60.2 0.0 3.3e-16 59.6 0.0 1.3 1 0 0 1 1 1 1 OsmC-like protein RNA_pol_I_A49 PF06870.12 EXF82188.1 - 2.4e-101 339.4 0.2 2.9e-101 339.1 0.2 1.1 1 0 0 1 1 1 1 A49-like RNA polymerase I associated factor ADSL_C PF10397.9 EXF82188.1 - 0.092 13.3 0.0 0.26 11.9 0.0 1.7 1 0 0 1 1 1 0 Adenylosuccinate lyase C-terminus ECH_1 PF00378.20 EXF82189.1 - 5.2e-25 88.2 0.0 9.1e-25 87.4 0.0 1.3 2 0 0 2 2 2 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EXF82189.1 - 8.7e-15 55.0 0.0 9.9e-15 54.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Vps51 PF08700.11 EXF82190.1 - 2.7e-12 46.6 0.0 9.7e-12 44.8 0.0 2.0 1 0 0 1 1 1 1 Vps51/Vps67 CaMKII_AD PF08332.10 EXF82190.1 - 0.037 14.2 0.0 0.086 13.0 0.0 1.5 1 0 0 1 1 1 0 Calcium/calmodulin dependent protein kinase II association domain RNA_pol_Rpc4 PF05132.14 EXF82190.1 - 0.21 12.0 4.0 0.5 10.8 4.0 1.6 1 0 0 1 1 1 0 RNA polymerase III RPC4 Nop14 PF04147.12 EXF82190.1 - 0.44 8.7 12.4 0.84 7.8 11.8 1.6 2 0 0 2 2 2 0 Nop14-like family SDA1 PF05285.12 EXF82190.1 - 0.48 9.8 13.6 0.92 8.9 13.6 1.4 1 0 0 1 1 1 0 SDA1 RR_TM4-6 PF06459.12 EXF82190.1 - 1.3 8.7 7.4 2.5 7.8 7.4 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CDC45 PF02724.14 EXF82190.1 - 1.6 6.9 8.8 2.5 6.3 8.8 1.2 1 0 0 1 1 1 0 CDC45-like protein SpoIIIAH PF12685.7 EXF82190.1 - 3.4 7.4 10.8 6.2 6.6 10.8 1.3 1 0 0 1 1 1 0 SpoIIIAH-like protein Sas10 PF09368.10 EXF82191.1 - 6.1e-30 103.5 10.8 6.1e-30 103.5 10.8 3.3 3 0 0 3 3 3 1 Sas10 C-terminal domain Sas10_Utp3 PF04000.15 EXF82191.1 - 5.7e-11 42.9 2.4 6.3e-10 39.5 0.0 3.0 2 0 0 2 2 2 1 Sas10/Utp3/C1D family Syntaxin_2 PF14523.6 EXF82191.1 - 3.3 8.1 11.5 1.4 9.4 0.1 3.2 3 0 0 3 3 3 0 Syntaxin-like protein adh_short PF00106.25 EXF82192.1 - 2.1e-32 112.2 0.0 2.6e-32 111.9 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF82192.1 - 6.6e-24 84.8 0.0 8.5e-24 84.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF82192.1 - 1.1e-08 35.2 0.0 1.8e-08 34.5 0.0 1.3 1 0 0 1 1 1 1 KR domain Shikimate_DH PF01488.20 EXF82192.1 - 0.0027 17.8 0.0 0.0047 17.0 0.0 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_10 PF13460.6 EXF82192.1 - 0.0056 16.6 0.2 0.018 14.9 0.2 1.9 1 1 0 1 1 1 1 NAD(P)H-binding THF_DHG_CYH_C PF02882.19 EXF82192.1 - 0.0089 15.3 0.0 0.013 14.8 0.0 1.2 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain ApbA PF02558.16 EXF82192.1 - 0.032 13.9 0.0 0.064 12.9 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA F420_oxidored PF03807.17 EXF82192.1 - 0.046 14.3 0.0 0.39 11.3 0.1 2.1 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent GDP_Man_Dehyd PF16363.5 EXF82192.1 - 0.1 11.9 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase vATP-synt_AC39 PF01992.16 EXF82193.1 - 0.15 11.5 0.1 0.22 11.0 0.1 1.2 1 0 0 1 1 1 0 ATP synthase (C/AC39) subunit Glyoxalase PF00903.25 EXF82194.1 - 6.6e-07 29.6 2.1 0.00049 20.3 0.6 2.8 2 1 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily FAD_binding_3 PF01494.19 EXF82195.1 - 1.1e-81 274.8 0.0 1.5e-81 274.4 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EXF82195.1 - 0.0018 17.6 0.0 0.0034 16.6 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EXF82195.1 - 0.0023 17.1 0.1 0.005 15.9 0.1 1.5 1 0 0 1 1 1 1 Lycopene cyclase protein NAD_binding_8 PF13450.6 EXF82195.1 - 0.043 14.0 0.7 0.12 12.6 0.7 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EXF82195.1 - 0.048 12.7 0.1 0.082 12.0 0.1 1.3 1 0 0 1 1 1 0 FAD binding domain Thi4 PF01946.17 EXF82195.1 - 0.073 12.3 0.2 0.13 11.4 0.2 1.3 1 0 0 1 1 1 0 Thi4 family GIDA PF01134.22 EXF82195.1 - 0.075 12.1 0.3 0.13 11.3 0.3 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A Pyr_redox PF00070.27 EXF82195.1 - 0.17 12.4 0.0 0.87 10.2 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase p450 PF00067.22 EXF82196.1 - 1.5e-55 188.8 0.0 6.7e-35 120.7 0.0 2.0 2 0 0 2 2 2 2 Cytochrome P450 Fungal_trans PF04082.18 EXF82197.1 - 8.3e-22 77.5 0.3 2.7e-21 75.8 0.1 1.9 2 0 0 2 2 2 1 Fungal specific transcription factor domain Med9 PF07544.13 EXF82197.1 - 0.083 13.0 0.2 0.24 11.5 0.2 1.7 1 0 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 FAA_hydrolase PF01557.18 EXF82198.1 - 1.3e-53 181.9 0.0 1.9e-53 181.4 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family adh_short_C2 PF13561.6 EXF82199.1 - 8.9e-52 176.0 0.2 1.2e-51 175.5 0.2 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF82199.1 - 9.2e-40 136.2 0.1 1.5e-39 135.5 0.1 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EXF82199.1 - 3.3e-07 30.4 0.0 6.5e-07 29.4 0.0 1.4 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 EXF82199.1 - 0.005 16.3 0.0 0.0083 15.6 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Metallophos_2 PF12850.7 EXF82199.1 - 0.042 14.0 0.0 0.089 13.0 0.0 1.5 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain adh_short_C2 PF13561.6 EXF82200.1 - 3.4e-63 213.3 0.3 3.9e-63 213.2 0.3 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF82200.1 - 8.9e-50 168.9 0.4 1.1e-49 168.6 0.4 1.0 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EXF82200.1 - 1.4e-14 54.4 0.3 2.1e-14 53.8 0.3 1.1 1 0 0 1 1 1 1 KR domain Peripla_BP_4 PF13407.6 EXF82200.1 - 0.0045 16.6 0.2 0.0063 16.1 0.2 1.2 1 0 0 1 1 1 1 Periplasmic binding protein domain Ldh_1_N PF00056.23 EXF82200.1 - 0.026 14.6 1.4 0.058 13.5 0.1 1.9 2 0 0 2 2 2 0 lactate/malate dehydrogenase, NAD binding domain Cupin_2 PF07883.11 EXF82201.1 - 4.5e-08 32.7 0.1 9.4e-08 31.7 0.1 1.5 1 0 0 1 1 1 1 Cupin domain Cupin_3 PF05899.12 EXF82201.1 - 2.6e-05 23.8 0.5 7.5e-05 22.3 0.1 2.0 2 1 1 3 3 3 1 Protein of unknown function (DUF861) Ectoine_synth PF06339.12 EXF82201.1 - 0.033 14.4 0.0 0.05 13.8 0.0 1.4 1 0 0 1 1 1 0 Ectoine synthase CDC45 PF02724.14 EXF82203.1 - 0.03 12.6 0.1 0.027 12.8 0.1 1.1 1 0 0 1 1 1 0 CDC45-like protein DDHD PF02862.17 EXF82203.1 - 0.046 13.9 0.1 0.055 13.6 0.1 1.2 1 0 0 1 1 1 0 DDHD domain PBP1_TM PF14812.6 EXF82203.1 - 1.4 9.3 11.8 2.9 8.3 11.8 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal UPF0560 PF10577.9 EXF82203.1 - 1.6 7.1 7.8 2.1 6.7 7.8 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 SAPS PF04499.15 EXF82203.1 - 7.4 5.2 6.5 10 4.8 6.5 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein HIP1_clath_bdg PF16515.5 EXF82204.1 - 0.019 15.6 11.0 0.019 15.6 11.0 2.1 2 1 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 MscS_porin PF12795.7 EXF82204.1 - 4.3 6.8 19.9 0.035 13.7 7.7 2.6 2 1 1 3 3 3 0 Mechanosensitive ion channel porin domain DUF2205 PF10224.9 EXF82204.1 - 5.1 7.2 7.9 1.7 8.7 0.0 2.8 3 0 0 3 3 3 0 Short coiled-coil protein RRM_1 PF00076.22 EXF82205.1 - 1.8e-16 59.7 0.6 2.4e-16 59.3 0.0 1.5 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) EPSP_synthase PF00275.20 EXF82206.1 - 1.6e-130 435.5 0.0 2.9e-130 434.7 0.0 1.4 1 0 0 1 1 1 1 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) DHQ_synthase PF01761.20 EXF82206.1 - 2.5e-100 335.0 0.0 3.9e-100 334.3 0.0 1.3 1 0 0 1 1 1 1 3-dehydroquinate synthase DHquinase_I PF01487.15 EXF82206.1 - 1.1e-58 199.2 0.0 2.2e-58 198.2 0.0 1.5 1 0 0 1 1 1 1 Type I 3-dehydroquinase SKI PF01202.22 EXF82206.1 - 8.6e-36 123.4 0.0 2.2e-34 118.9 0.0 2.3 2 0 0 2 2 2 1 Shikimate kinase Shikimate_dh_N PF08501.11 EXF82206.1 - 3.3e-22 78.5 0.0 7.2e-22 77.4 0.0 1.6 1 0 0 1 1 1 1 Shikimate dehydrogenase substrate binding domain Fe-ADH_2 PF13685.6 EXF82206.1 - 1.3e-09 38.2 0.0 2.6e-09 37.2 0.0 1.5 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase SDH_C PF18317.1 EXF82206.1 - 0.00021 21.0 0.1 0.00062 19.5 0.1 1.9 1 0 0 1 1 1 1 Shikimate 5'-dehydrogenase C-terminal domain AAA_22 PF13401.6 EXF82206.1 - 0.044 14.1 0.0 0.15 12.3 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EXF82206.1 - 0.1 12.8 0.0 0.38 10.9 0.0 2.0 1 0 0 1 1 1 0 AAA domain zf-C2H2 PF00096.26 EXF82207.1 - 0.00017 21.9 32.3 0.0061 17.0 1.6 4.4 5 0 0 5 5 5 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EXF82207.1 - 0.0011 19.6 11.4 1.9 9.5 1.3 4.0 3 0 0 3 3 3 3 C2H2-type zinc finger DTW PF03942.15 EXF82207.1 - 0.0099 15.6 0.8 0.03 14.0 0.1 2.1 2 0 0 2 2 2 1 DTW domain zf-Di19 PF05605.12 EXF82207.1 - 3.1 8.2 6.0 4.2 7.7 2.0 2.6 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding L31 PF09784.9 EXF82208.1 - 2.3e-23 82.5 0.0 4e-23 81.8 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L31 Sedlin_N PF04628.13 EXF82209.1 - 2.3e-46 157.1 0.0 2.7e-46 156.9 0.0 1.0 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Sybindin PF04099.12 EXF82209.1 - 0.00036 20.5 0.1 0.022 14.7 0.0 2.2 1 1 1 2 2 2 2 Sybindin-like family CENP-T_C PF15511.6 EXF82210.1 - 8e-09 35.6 0.1 9.7e-09 35.3 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold Histone PF00125.24 EXF82210.1 - 3.5e-05 24.2 0.1 4.1e-05 23.9 0.1 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TAF PF02969.17 EXF82210.1 - 8.6e-05 22.6 0.1 0.00013 22.1 0.1 1.4 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CBFD_NFYB_HMF PF00808.23 EXF82210.1 - 0.00036 20.7 0.1 0.00065 19.9 0.0 1.5 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-S PF15630.6 EXF82210.1 - 0.00042 20.7 0.1 0.00056 20.2 0.1 1.4 1 1 0 1 1 1 1 CENP-S protein TFIID-31kDa PF02291.15 EXF82210.1 - 0.0087 16.1 0.0 0.01 15.9 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 EXF82210.1 - 0.023 14.7 0.0 0.027 14.5 0.0 1.3 1 0 0 1 1 1 0 Bromodomain associated UPF0137 PF03677.13 EXF82210.1 - 0.095 12.5 0.1 0.12 12.2 0.1 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0137) HIGH_NTase1_ass PF16581.5 EXF82210.1 - 0.11 12.5 0.0 0.12 12.4 0.0 1.1 1 0 0 1 1 1 0 Cytidyltransferase-related C-terminal region Histone PF00125.24 EXF82211.1 - 1.6e-51 174.1 2.5 1.8e-51 173.9 2.5 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.6 EXF82211.1 - 8.4e-06 26.1 0.0 1.3e-05 25.5 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein PAF PF15715.5 EXF82211.1 - 3.4e-05 24.5 1.0 3.9e-05 24.3 1.0 1.2 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CENP-T_C PF15511.6 EXF82211.1 - 3.6e-05 23.8 0.4 6.4e-05 23.0 0.1 1.6 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold CBFD_NFYB_HMF PF00808.23 EXF82211.1 - 0.0035 17.6 0.3 0.0065 16.7 0.0 1.5 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 EXF82211.1 - 0.028 14.5 0.2 0.046 13.8 0.0 1.5 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 EXF82211.1 - 0.057 13.4 0.0 0.097 12.7 0.0 1.4 1 0 0 1 1 1 0 Bromodomain associated PRP3 PF08572.10 EXF82212.1 - 1.5e-70 237.4 8.3 1.5e-70 237.4 8.3 1.5 2 0 0 2 2 2 1 pre-mRNA processing factor 3 (PRP3) DUF1115 PF06544.12 EXF82212.1 - 7e-47 159.2 3.1 7e-47 159.2 3.1 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF1115) bZIP_C PF12498.8 EXF82212.1 - 0.016 16.2 0.7 1 10.3 0.1 2.8 2 0 0 2 2 2 0 Basic leucine-zipper C terminal BLUF PF04940.12 EXF82212.1 - 0.042 14.0 1.0 5 7.3 0.1 2.9 3 0 0 3 3 3 0 Sensors of blue-light using FAD RNA_pol_Rpb1_5 PF04998.17 EXF82213.1 - 2.5e-86 289.4 0.0 4.2e-86 288.7 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 EXF82213.1 - 1.3e-68 230.4 0.1 3.3e-68 229.1 0.1 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_1 PF04997.12 EXF82213.1 - 2.3e-35 122.4 0.4 8.2e-34 117.3 0.2 2.9 2 1 0 2 2 2 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_3 PF04983.18 EXF82213.1 - 2.9e-33 115.0 0.0 8.4e-33 113.5 0.0 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 EXF82213.1 - 2.2e-16 59.7 0.2 1.2e-15 57.4 0.1 2.4 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 4 TPR_1 PF00515.28 EXF82214.1 - 3.2e-44 147.0 15.5 3.9e-07 29.6 0.1 10.5 10 0 0 10 10 10 7 Tetratricopeptide repeat TPR_2 PF07719.17 EXF82214.1 - 2.8e-36 120.7 24.8 4.5e-05 23.2 0.0 11.0 11 0 0 11 11 11 7 Tetratricopeptide repeat ANAPC3 PF12895.7 EXF82214.1 - 1e-30 105.8 17.1 1.1e-22 80.0 0.2 6.0 5 1 2 7 7 7 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 EXF82214.1 - 2e-30 102.4 15.5 0.006 16.7 0.0 10.7 11 0 0 11 11 10 7 Tetratricopeptide repeat TPR_17 PF13431.6 EXF82214.1 - 7.4e-22 76.1 7.8 0.0086 16.4 0.0 9.7 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_7 PF13176.6 EXF82214.1 - 5.1e-21 73.1 6.1 0.041 13.9 0.0 8.8 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_19 PF14559.6 EXF82214.1 - 1.4e-20 73.5 11.5 7.8e-05 23.1 0.9 7.8 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_12 PF13424.6 EXF82214.1 - 9.5e-20 70.7 21.5 0.00039 20.6 0.1 8.7 4 2 4 8 8 8 7 Tetratricopeptide repeat TPR_11 PF13414.6 EXF82214.1 - 1.3e-19 69.6 6.3 7.3e-05 22.4 0.3 9.6 9 1 1 10 10 10 5 TPR repeat TPR_14 PF13428.6 EXF82214.1 - 1.5e-19 69.0 18.3 0.097 13.5 0.2 10.9 4 3 6 11 11 11 5 Tetratricopeptide repeat TPR_16 PF13432.6 EXF82214.1 - 4.6e-18 65.6 17.8 7.8e-07 29.6 0.3 8.0 7 1 0 8 8 8 3 Tetratricopeptide repeat TPR_6 PF13174.6 EXF82214.1 - 3.9e-11 42.8 10.7 2.2 9.1 0.0 9.2 10 0 0 10 10 10 4 Tetratricopeptide repeat TPR_15 PF13429.6 EXF82214.1 - 8.3e-08 31.8 13.0 0.043 13.0 1.9 4.8 3 1 2 5 5 5 3 Tetratricopeptide repeat TPR_9 PF13371.6 EXF82214.1 - 2.8e-06 27.4 8.9 4.6 7.5 0.2 6.6 5 2 2 7 7 7 3 Tetratricopeptide repeat DUF2225 PF09986.9 EXF82214.1 - 5.8e-05 22.9 3.4 0.023 14.4 1.5 3.3 2 1 1 3 3 3 1 Uncharacterized protein conserved in bacteria (DUF2225) Fis1_TPR_C PF14853.6 EXF82214.1 - 0.075 13.1 2.3 22 5.2 0.0 5.4 6 0 0 6 6 5 0 Fis1 C-terminal tetratricopeptide repeat TPR_4 PF07721.14 EXF82214.1 - 0.2 12.4 7.4 8.5 7.3 0.0 4.4 5 0 0 5 5 4 0 Tetratricopeptide repeat DUF5113 PF17140.4 EXF82214.1 - 1.6 8.5 4.7 0.46 10.3 0.6 2.3 3 0 0 3 3 2 0 Domain of unknown function (DUF5113) TMEM208_SND2 PF05620.11 EXF82215.1 - 1.6e-53 180.9 0.2 1.8e-53 180.8 0.2 1.0 1 0 0 1 1 1 1 SRP-independent targeting protein 2/TMEM208 DUF3605 PF12239.8 EXF82216.1 - 2.6e-59 199.9 0.0 3.2e-59 199.7 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3605) EBP PF05241.12 EXF82217.1 - 3.1e-57 192.9 8.2 3.9e-57 192.6 8.2 1.1 1 0 0 1 1 1 1 Emopamil binding protein p450 PF00067.22 EXF82220.1 - 5.1e-60 203.5 0.0 7.9e-60 202.9 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 Fungal_trans PF04082.18 EXF82220.1 - 7.3e-14 51.4 0.6 1.3e-13 50.6 0.6 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF82220.1 - 3.8e-05 23.7 10.5 7.7e-05 22.7 10.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FAD_binding_4 PF01565.23 EXF82221.1 - 2.6e-23 82.3 0.0 4.6e-23 81.5 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain FAD-oxidase_C PF02913.19 EXF82221.1 - 2.7e-13 50.1 0.0 3.9e-13 49.6 0.0 1.2 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain Hydrolase_4 PF12146.8 EXF82222.1 - 7.8e-13 48.2 0.1 2.4e-12 46.7 0.1 1.8 1 1 1 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EXF82222.1 - 8.7e-13 49.4 3.2 8.7e-13 49.4 3.2 1.5 2 0 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EXF82222.1 - 2.5e-11 43.7 0.0 4.3e-11 43.0 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.7 EXF82222.1 - 0.0094 15.7 0.0 0.025 14.4 0.0 1.6 1 0 0 1 1 1 1 Alpha/beta hydrolase family UPF0227 PF05728.12 EXF82222.1 - 0.063 13.2 0.0 1.1 9.2 0.0 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0227) adh_short PF00106.25 EXF82224.1 - 4.7e-44 150.2 0.5 5.9e-44 149.9 0.5 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF82224.1 - 2e-40 138.8 1.1 1.8e-39 135.7 1.1 1.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 EXF82224.1 - 0.00043 19.8 0.1 0.0023 17.4 0.0 1.8 1 1 1 2 2 2 1 NAD dependent epimerase/dehydratase family KR PF08659.10 EXF82224.1 - 0.0029 17.6 0.3 0.0063 16.4 0.3 1.5 1 0 0 1 1 1 1 KR domain GDP_Man_Dehyd PF16363.5 EXF82224.1 - 0.12 11.8 0.0 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase DCP2 PF05026.13 EXF82225.1 - 2.2e-30 104.8 0.1 4e-30 104.0 0.1 1.4 1 0 0 1 1 1 1 Dcp2, box A domain NUDIX PF00293.28 EXF82225.1 - 1.7e-15 57.2 0.1 3.2e-15 56.3 0.1 1.4 1 0 0 1 1 1 1 NUDIX domain DUF4112 PF13430.6 EXF82226.1 - 4.1e-36 123.4 0.3 5.3e-36 123.1 0.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4112) AgrD PF05931.11 EXF82226.1 - 0.11 12.5 0.3 0.18 11.9 0.3 1.3 1 0 0 1 1 1 0 Staphylococcal AgrD protein Ribonuc_red_sm PF00268.21 EXF82227.1 - 4.6e-121 403.6 2.2 5.8e-121 403.2 2.2 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain SRP9-21 PF05486.12 EXF82228.1 - 6e-19 68.2 0.0 1.1e-18 67.4 0.0 1.4 1 0 0 1 1 1 1 Signal recognition particle 9 kDa protein (SRP9) Mito_carr PF00153.27 EXF82229.1 - 1.8e-42 143.2 0.9 7.8e-16 57.8 0.4 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Suv3_N PF18114.1 EXF82229.1 - 0.054 13.6 0.0 0.36 11.0 0.0 2.0 2 0 0 2 2 2 0 Suv3 helical N-terminal domain CTU2 PF10288.9 EXF82230.1 - 1.9e-12 47.4 4.0 2e-11 44.1 0.1 3.1 3 1 0 3 3 3 1 Cytoplasmic tRNA 2-thiolation protein 2 DZR PF12773.7 EXF82230.1 - 0.59 10.2 4.9 11 6.1 0.1 2.4 2 0 0 2 2 2 0 Double zinc ribbon zf-FPG_IleRS PF06827.14 EXF82230.1 - 4.3 7.3 8.2 7.9 6.4 6.3 2.3 2 0 0 2 2 2 0 Zinc finger found in FPG and IleRS APH PF01636.23 EXF82231.1 - 7.5e-09 35.9 0.0 9.6e-09 35.5 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EXF82231.1 - 1.1e-06 28.4 0.0 1.6e-06 27.9 0.0 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase EcKinase PF02958.20 EXF82231.1 - 1.5e-05 24.5 0.1 2.2e-05 23.9 0.1 1.2 1 0 0 1 1 1 1 Ecdysteroid kinase Kdo PF06293.14 EXF82231.1 - 0.07 12.5 0.3 0.34 10.2 0.0 2.0 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Fructosamin_kin PF03881.14 EXF82231.1 - 0.12 11.5 0.0 0.2 10.8 0.0 1.3 1 0 0 1 1 1 0 Fructosamine kinase PH PF00169.29 EXF82232.1 - 1.4e-27 96.2 1.8 3.3e-16 59.7 0.2 2.2 2 0 0 2 2 2 2 PH domain PH_11 PF15413.6 EXF82232.1 - 7.3e-10 39.2 5.7 0.00018 21.9 0.8 3.1 2 1 0 2 2 2 2 Pleckstrin homology domain PH_9 PF15410.6 EXF82232.1 - 2.9e-08 34.1 2.1 3.2e-05 24.3 0.5 3.5 2 2 0 2 2 2 2 Pleckstrin homology domain PH_8 PF15409.6 EXF82232.1 - 9.7e-06 25.8 0.2 2e-05 24.8 0.2 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain PH_3 PF14593.6 EXF82232.1 - 0.0062 16.6 0.6 0.027 14.6 0.3 2.2 2 1 0 2 2 2 1 PH domain Cellulase PF00150.18 EXF82233.1 - 2.3e-19 69.9 1.2 4.3e-19 69.0 1.2 1.4 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) efThoc1 PF11957.8 EXF82234.1 - 1.5e-142 475.8 7.8 1.5e-142 475.8 7.8 1.4 2 0 0 2 2 1 1 THO complex subunit 1 transcription elongation factor Guanylate_kin PF00625.21 EXF82234.1 - 1.5e-30 106.2 0.0 3.5e-30 105.0 0.0 1.7 1 0 0 1 1 1 1 Guanylate kinase AAA_33 PF13671.6 EXF82234.1 - 0.00014 22.0 0.0 0.001 19.3 0.0 2.4 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EXF82234.1 - 0.0002 21.9 0.1 0.0011 19.6 0.0 2.4 2 1 0 2 2 2 1 AAA domain AAA_28 PF13521.6 EXF82234.1 - 0.00031 21.0 0.0 0.0012 19.1 0.0 2.1 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EXF82234.1 - 0.0026 18.1 0.0 0.012 15.9 0.0 2.2 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 EXF82234.1 - 0.0043 17.1 0.0 0.013 15.5 0.0 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase RNA_helicase PF00910.22 EXF82234.1 - 0.0048 17.3 0.0 1.1 9.7 0.0 2.8 2 0 0 2 2 2 1 RNA helicase AAA PF00004.29 EXF82234.1 - 0.013 15.9 0.0 0.037 14.5 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EXF82234.1 - 0.014 15.1 0.0 0.079 12.7 0.0 2.0 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EXF82234.1 - 0.015 15.7 0.0 0.062 13.7 0.0 2.0 1 0 0 1 1 1 0 AAA ATPase domain Fe_hyd_lg_C PF02906.14 EXF82234.1 - 0.018 14.7 1.9 0.055 13.1 1.9 1.8 1 0 0 1 1 1 0 Iron only hydrogenase large subunit, C-terminal domain AAA_5 PF07728.14 EXF82234.1 - 0.036 14.1 0.0 0.14 12.1 0.0 2.0 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Zeta_toxin PF06414.12 EXF82234.1 - 0.046 13.0 0.0 0.12 11.6 0.0 1.7 1 0 0 1 1 1 0 Zeta toxin ABC_tran PF00005.27 EXF82234.1 - 0.064 13.8 0.0 0.22 12.0 0.0 2.0 1 0 0 1 1 1 0 ABC transporter Rad17 PF03215.15 EXF82234.1 - 0.075 12.9 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain NACHT PF05729.12 EXF82234.1 - 0.083 12.8 0.0 0.3 11.0 0.0 2.0 1 0 0 1 1 1 0 NACHT domain IstB_IS21 PF01695.17 EXF82234.1 - 0.093 12.5 0.0 0.22 11.2 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein TsaE PF02367.17 EXF82234.1 - 0.1 12.6 0.0 0.26 11.3 0.0 1.7 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE cobW PF02492.19 EXF82234.1 - 0.12 11.9 0.0 0.27 10.8 0.0 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain Aquarius_N PF16399.5 EXF82235.1 - 0 1117.9 0.0 0 1117.5 0.0 1.1 1 0 0 1 1 1 1 Intron-binding protein aquarius N-terminus AAA_12 PF13087.6 EXF82235.1 - 1.8e-26 93.0 0.0 3.4e-26 92.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 EXF82235.1 - 1.7e-20 73.9 0.5 7.2e-20 71.9 0.0 2.3 2 1 0 2 2 1 1 AAA domain AAA_30 PF13604.6 EXF82235.1 - 6.6e-08 32.5 0.0 0.00021 21.1 0.0 2.6 2 0 0 2 2 2 2 AAA domain ResIII PF04851.15 EXF82235.1 - 6e-06 26.4 0.0 1.5e-05 25.1 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 EXF82235.1 - 9.4e-06 26.0 0.0 2.1e-05 24.9 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EXF82235.1 - 0.00079 19.9 0.6 0.013 15.8 0.0 3.1 2 1 0 2 2 2 1 AAA ATPase domain AAA PF00004.29 EXF82235.1 - 0.0018 18.7 0.0 0.0063 16.9 0.0 2.0 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DnaB_C PF03796.15 EXF82235.1 - 0.0041 16.5 0.0 0.0088 15.4 0.0 1.5 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain Viral_helicase1 PF01443.18 EXF82235.1 - 0.0053 16.5 0.2 0.38 10.5 0.0 3.1 4 0 0 4 4 4 1 Viral (Superfamily 1) RNA helicase AAA_22 PF13401.6 EXF82235.1 - 0.029 14.6 0.0 0.14 12.4 0.0 2.2 2 0 0 2 2 1 0 AAA domain DEAD PF00270.29 EXF82235.1 - 0.035 13.9 0.0 0.085 12.6 0.0 1.7 1 0 0 1 1 1 0 DEAD/DEAH box helicase RuvB_N PF05496.12 EXF82235.1 - 0.047 13.4 0.1 2.3 7.9 0.0 2.4 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain PIF1 PF05970.14 EXF82235.1 - 0.063 12.4 0.0 1.6 7.8 0.0 2.2 2 0 0 2 2 2 0 PIF1-like helicase UvrD-helicase PF00580.21 EXF82235.1 - 0.069 12.7 0.4 0.36 10.3 0.0 2.3 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain DUF2075 PF09848.9 EXF82235.1 - 0.14 11.4 0.9 0.2 10.9 0.0 1.7 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) ATPase_2 PF01637.18 EXF82235.1 - 0.17 11.8 0.0 1.2 8.9 0.0 2.2 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea MIF4G PF02854.19 EXF82236.1 - 1.6e-51 174.9 0.0 2.7e-51 174.2 0.0 1.4 1 0 0 1 1 1 1 MIF4G domain eIF_4G1 PF12152.8 EXF82236.1 - 4.4e-23 81.2 1.2 1.1e-22 79.9 1.2 1.8 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 4G1 DUF4148 PF13663.6 EXF82236.1 - 0.0057 16.8 0.8 1.7 8.9 0.1 3.2 2 0 0 2 2 2 2 Domain of unknown function (DUF4148) DNA_pol_B PF00136.21 EXF82237.1 - 2.8e-118 395.5 0.2 4e-118 395.0 0.2 1.2 1 0 0 1 1 1 1 DNA polymerase family B zf-DNA_Pol PF08996.10 EXF82237.1 - 8.8e-70 234.2 0.7 1.7e-69 233.3 0.7 1.5 1 0 0 1 1 1 1 DNA Polymerase alpha zinc finger DNA_pol_B_exo1 PF03104.19 EXF82237.1 - 5.2e-41 140.9 0.0 1.1e-40 139.8 0.0 1.6 2 0 0 2 2 2 1 DNA polymerase family B, exonuclease domain DNA_pol_alpha_N PF12254.8 EXF82237.1 - 2.5e-23 81.9 10.1 2.5e-23 81.9 10.1 2.3 2 0 0 2 2 2 1 DNA polymerase alpha subunit p180 N terminal DNA_pol_B_2 PF03175.13 EXF82237.1 - 0.0093 14.9 0.0 0.021 13.7 0.0 1.5 1 0 0 1 1 1 1 DNA polymerase type B, organellar and viral PPR_2 PF13041.6 EXF82238.1 - 1.8e-21 76.0 1.0 1.2e-13 51.0 0.0 5.3 5 1 1 6 6 6 2 PPR repeat family PPR PF01535.20 EXF82238.1 - 1.5e-07 31.2 5.8 1.7 9.0 0.0 7.2 8 1 0 8 8 8 2 PPR repeat PPR_3 PF13812.6 EXF82238.1 - 6.7e-07 29.3 1.1 0.011 15.7 0.0 4.1 3 1 1 4 4 4 3 Pentatricopeptide repeat domain PPR_long PF17177.4 EXF82238.1 - 9.3e-07 28.4 1.2 7.7e-06 25.4 0.2 2.5 2 0 0 2 2 2 1 Pentacotripeptide-repeat region of PRORP PPR_1 PF12854.7 EXF82238.1 - 0.00014 21.5 2.0 1.4 8.7 0.0 5.8 6 0 0 6 6 6 1 PPR repeat TPR_14 PF13428.6 EXF82238.1 - 0.011 16.5 1.1 13 7.0 0.0 4.2 3 1 1 4 4 4 0 Tetratricopeptide repeat CCAP PF11105.8 EXF82238.1 - 0.06 13.3 0.9 2.1 8.3 0.0 3.0 3 0 0 3 3 3 0 Arthropod cardioacceleratory peptide 2a ATP13 PF12921.7 EXF82238.1 - 0.087 12.7 0.7 2.1 8.3 0.0 2.9 3 0 0 3 3 3 0 Mitochondrial ATPase expression aGPT-Pplase3 PF18746.1 EXF82238.1 - 0.094 12.0 1.2 6.1 6.1 0.1 3.1 3 0 0 3 3 3 0 Alpha-glutamyl/putrescinyl thymine pyrophosphorylase clade 3 Plk4_PB2 PF18409.1 EXF82238.1 - 4.7 7.9 6.4 1.5e+02 3.1 0.0 4.2 3 1 0 3 3 3 0 Polo-like Kinase 4 Polo Box 2 RNA_pol_I_A49 PF06870.12 EXF82239.1 - 0.055 12.3 5.7 0.31 9.8 5.6 2.0 1 1 0 1 1 1 0 A49-like RNA polymerase I associated factor Pkinase PF00069.25 EXF82240.1 - 1.1e-50 172.5 0.1 3.8e-50 170.7 0.1 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF82240.1 - 2.5e-23 82.7 0.0 5e-23 81.7 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EXF82240.1 - 0.00032 20.7 2.4 0.00034 20.6 0.1 2.1 2 0 0 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.22 EXF82240.1 - 0.0027 17.3 0.2 0.0073 15.9 0.2 1.6 1 1 0 1 1 1 1 RIO1 family Choline_kinase PF01633.20 EXF82240.1 - 0.58 9.7 2.3 0.39 10.3 0.2 1.8 2 0 0 2 2 2 0 Choline/ethanolamine kinase CoaE PF01121.20 EXF82241.1 - 1.8e-42 145.0 0.0 7.1e-42 143.1 0.0 1.8 1 1 0 1 1 1 1 Dephospho-CoA kinase AAA_18 PF13238.6 EXF82241.1 - 0.0097 16.4 0.1 0.31 11.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EXF82241.1 - 0.081 13.1 0.0 0.66 10.1 0.0 2.3 1 1 0 1 1 1 0 AAA domain RRM_1 PF00076.22 EXF82242.1 - 2.2e-60 200.4 0.0 2.4e-21 75.3 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EXF82242.1 - 7.2e-10 38.5 0.0 4.2e-06 26.4 0.0 3.2 2 1 1 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EXF82242.1 - 7.3e-10 38.6 0.0 0.0093 15.8 0.0 3.4 3 1 0 3 3 3 2 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 EXF82242.1 - 1e-06 28.6 0.1 0.12 12.4 0.0 3.5 3 0 0 3 3 3 2 Nup53/35/40-type RNA recognition motif Cas_Cas2CT1978 PF09707.10 EXF82242.1 - 0.00026 21.0 0.0 0.43 10.7 0.0 2.3 2 0 0 2 2 2 2 CRISPR-associated protein (Cas_Cas2CT1978) RRM_8 PF11835.8 EXF82242.1 - 0.00039 20.6 0.0 0.15 12.3 0.0 2.3 2 0 0 2 2 2 2 RRM-like domain RRM_7 PF16367.5 EXF82242.1 - 0.00074 19.6 0.1 0.45 10.7 0.0 3.1 3 1 0 3 3 3 1 RNA recognition motif RRM_3 PF08777.11 EXF82242.1 - 0.052 13.6 0.0 0.91 9.6 0.0 2.2 2 0 0 2 2 2 0 RNA binding motif SET_assoc PF11767.8 EXF82242.1 - 0.2 11.3 0.0 22 4.8 0.0 2.3 2 0 0 2 2 2 0 Histone lysine methyltransferase SET associated DUF2057 PF09829.9 EXF82243.1 - 0.29 11.3 3.1 4.6 7.4 0.5 2.6 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2057) LON_substr_bdg PF02190.16 EXF82244.1 - 1.6e-28 100.0 0.0 4.6e-28 98.5 0.0 1.7 2 0 0 2 2 2 1 ATP-dependent protease La (LON) substrate-binding domain zf-C3HC4_4 PF15227.6 EXF82244.1 - 9.1e-05 22.5 4.4 0.0002 21.5 4.4 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 EXF82244.1 - 0.089 12.8 5.6 0.18 11.8 5.6 1.6 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4 PF00097.25 EXF82244.1 - 0.12 12.2 2.7 0.33 10.9 2.7 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EXF82244.1 - 0.38 10.8 6.5 1 9.4 6.5 1.8 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EXF82244.1 - 1.8 8.5 5.7 0.64 9.9 2.3 2.0 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) INSIG PF07281.12 EXF82246.1 - 7.7e-89 296.9 0.3 9.9e-89 296.6 0.3 1.1 1 0 0 1 1 1 1 Insulin-induced protein (INSIG) WD40 PF00400.32 EXF82247.1 - 7.8e-13 48.7 0.1 0.65 11.0 0.0 7.2 7 0 0 7 7 7 4 WD domain, G-beta repeat Nucleoporin_N PF08801.11 EXF82247.1 - 0.00027 19.8 0.0 0.54 8.9 0.0 3.0 1 1 2 3 3 3 3 Nup133 N terminal like Pkinase PF00069.25 EXF82248.1 - 2.1e-39 135.5 0.0 3.1e-39 134.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF82248.1 - 2e-26 92.8 0.0 3.3e-26 92.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EXF82248.1 - 0.072 12.4 0.0 0.1 11.9 0.0 1.2 1 0 0 1 1 1 0 Kinase-like APH PF01636.23 EXF82248.1 - 0.15 12.0 0.4 13 5.6 0.0 2.8 2 1 1 3 3 3 0 Phosphotransferase enzyme family AA_permease PF00324.21 EXF82249.1 - 1.9e-139 465.3 37.8 2.4e-139 465.1 37.8 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EXF82249.1 - 3.6e-41 141.4 42.4 4.8e-41 141.0 42.4 1.0 1 0 0 1 1 1 1 Amino acid permease DUF1749 PF08538.10 EXF82251.1 - 1.1e-86 290.7 0.0 1.2e-86 290.5 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1749) Abhydrolase_6 PF12697.7 EXF82251.1 - 3e-08 34.5 0.0 3.6e-08 34.3 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EXF82251.1 - 1.5e-07 30.9 0.0 8e-05 22.0 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EXF82251.1 - 1e-06 28.6 0.0 4.1e-05 23.3 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EXF82251.1 - 0.00011 21.8 0.0 0.037 13.5 0.0 2.6 3 0 0 3 3 3 2 Prolyl oligopeptidase family Ser_hydrolase PF06821.13 EXF82251.1 - 0.019 14.8 0.0 0.048 13.5 0.0 1.8 1 1 0 1 1 1 0 Serine hydrolase DLH PF01738.18 EXF82251.1 - 0.02 14.4 0.0 3.5 7.1 0.0 2.2 2 0 0 2 2 2 0 Dienelactone hydrolase family LIP PF03583.14 EXF82251.1 - 0.051 12.9 0.0 0.086 12.1 0.0 1.4 1 0 0 1 1 1 0 Secretory lipase p450 PF00067.22 EXF82253.1 - 1.9e-48 165.4 0.0 5.7e-48 163.8 0.0 1.6 1 1 0 1 1 1 1 Cytochrome P450 eIF-5_eIF-2B PF01873.17 EXF82254.1 - 3.5e-39 133.3 0.0 8.1e-39 132.1 0.0 1.6 1 0 0 1 1 1 1 Domain found in IF2B/IF5 W2 PF02020.18 EXF82254.1 - 3.3e-23 81.6 1.5 3.3e-23 81.6 1.5 2.2 2 0 0 2 2 2 1 eIF4-gamma/eIF5/eIF2-epsilon Tim17 PF02466.19 EXF82257.1 - 6.7e-25 87.6 5.4 9.9e-25 87.1 5.4 1.3 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Endonuclease_5 PF04493.14 EXF82257.1 - 0.009 15.7 0.0 0.012 15.3 0.0 1.1 1 0 0 1 1 1 1 Endonuclease V MARVEL PF01284.23 EXF82258.1 - 2.7e-20 72.8 0.4 3.8e-20 72.4 0.4 1.2 1 0 0 1 1 1 1 Membrane-associating domain Phage_holin_3_6 PF07332.11 EXF82258.1 - 0.83 9.7 6.1 1.3 9.1 2.9 2.2 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III DUF2834 PF11196.8 EXF82259.1 - 0.0019 18.5 5.5 0.0091 16.3 0.5 3.1 3 0 0 3 3 3 2 Protein of unknown function (DUF2834) Tis11B_N PF04553.12 EXF82261.1 - 0.025 15.1 1.5 0.065 13.8 0.3 1.9 2 0 0 2 2 2 0 Tis11B like protein, N terminus Stn1_C PF12659.7 EXF82262.1 - 0.022 14.7 1.1 2.1 8.3 0.3 2.6 2 0 0 2 2 2 0 Telomere capping C-terminal wHTH Mad3_BUB1_I PF08311.12 EXF82262.1 - 0.035 14.1 0.4 19 5.3 0.1 3.0 3 0 0 3 3 3 0 Mad3/BUB1 homology region 1 TilS PF09179.11 EXF82262.1 - 0.19 12.3 1.2 0.49 10.9 0.0 2.2 3 0 0 3 3 3 0 TilS substrate binding domain Cas1_AcylT PF07779.12 EXF82263.1 - 1.3e-111 373.9 14.0 1.8e-111 373.4 14.0 1.1 1 0 0 1 1 1 1 10 TM Acyl Transferase domain found in Cas1p DUF4834 PF16118.5 EXF82263.1 - 1.2 10.1 5.5 1.2 10.1 1.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) FAM76 PF16046.5 EXF82263.1 - 2.9 7.2 5.2 5 6.4 5.2 1.3 1 0 0 1 1 1 0 FAM76 protein Ribosomal_S13 PF00416.22 EXF82264.1 - 3.1e-50 169.8 2.9 3.5e-38 130.9 1.4 2.0 1 1 1 2 2 2 2 Ribosomal protein S13/S18 Syntaxin-6_N PF09177.11 EXF82264.1 - 0.038 14.6 0.0 0.079 13.5 0.0 1.6 1 1 0 1 1 1 0 Syntaxin 6, N-terminal PP28 PF10252.9 EXF82264.1 - 0.092 13.2 0.3 0.24 11.9 0.3 1.7 1 0 0 1 1 1 0 Casein kinase substrate phosphoprotein PP28 SBDS_C PF09377.10 EXF82265.1 - 1.1e-44 151.2 0.0 1.7e-44 150.6 0.0 1.3 1 0 0 1 1 1 1 SBDS protein C-terminal domain SBDS PF01172.18 EXF82265.1 - 3.2e-35 120.0 0.1 4.9e-35 119.5 0.1 1.3 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein Peptidase_S10 PF00450.22 EXF82266.1 - 3e-128 428.8 1.5 3.8e-128 428.5 1.5 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase Carbpep_Y_N PF05388.11 EXF82266.1 - 4.5e-17 62.7 5.7 3.9e-16 59.7 5.7 2.3 1 1 0 1 1 1 1 Carboxypeptidase Y pro-peptide PDEase_I PF00233.19 EXF82268.1 - 3.8e-65 219.9 0.0 5.4e-65 219.4 0.0 1.2 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase Adaptin_N PF01602.20 EXF82269.1 - 1.6e-120 403.1 9.4 2e-120 402.8 9.4 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EXF82269.1 - 1.5e-55 187.6 9.5 2e-55 187.3 0.2 3.4 3 1 1 4 4 4 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EXF82269.1 - 2.5e-15 56.6 5.6 5.4e-05 23.5 0.1 4.9 4 1 1 5 5 5 4 HEAT repeats HEAT PF02985.22 EXF82269.1 - 2e-10 40.0 4.3 0.00065 19.7 0.0 5.5 6 0 0 6 6 6 3 HEAT repeat CLASP_N PF12348.8 EXF82269.1 - 0.00015 21.4 0.2 0.046 13.3 0.0 2.7 2 0 0 2 2 2 2 CLASP N terminal HEAT_EZ PF13513.6 EXF82269.1 - 0.0021 18.5 5.1 23 5.7 0.0 6.0 6 0 0 6 6 6 0 HEAT-like repeat Atx10homo_assoc PF09759.9 EXF82269.1 - 0.0024 17.8 0.2 19 5.4 0.0 4.8 5 1 0 5 5 5 1 Spinocerebellar ataxia type 10 protein domain RTP1_C1 PF10363.9 EXF82269.1 - 0.0045 17.1 1.3 0.61 10.3 0.0 3.5 2 1 1 3 3 3 1 Required for nuclear transport of RNA pol II C-terminus 1 Arm PF00514.23 EXF82269.1 - 0.55 10.4 3.4 9.7 6.4 0.1 4.2 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat DUF1077 PF06417.12 EXF82270.1 - 5e-50 168.4 6.1 7.4e-50 167.9 6.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1077) MFS_1 PF07690.16 EXF82272.1 - 1.2e-46 159.2 18.8 1.2e-46 159.2 18.8 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF82272.1 - 2.4e-10 39.9 0.9 2.4e-10 39.9 0.9 2.6 3 0 0 3 3 3 2 Sugar (and other) transporter OATP PF03137.20 EXF82272.1 - 0.11 10.7 1.5 0.22 9.8 1.5 1.5 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family MFS_3 PF05977.13 EXF82272.1 - 1.3 7.3 17.0 0.012 14.0 6.8 2.3 3 0 0 3 3 3 0 Transmembrane secretion effector Syntaxin-18_N PF10496.9 EXF82273.1 - 4.1e-10 39.8 1.0 1.5e-09 38.0 0.2 2.5 2 0 0 2 2 2 1 SNARE-complex protein Syntaxin-18 N-terminus SNARE PF05739.19 EXF82273.1 - 0.0095 15.9 0.0 0.033 14.2 0.0 1.9 1 0 0 1 1 1 1 SNARE domain Phage_int_SAM_2 PF12834.7 EXF82273.1 - 0.51 11.0 4.1 12 6.6 0.0 3.7 4 0 0 4 4 4 0 Phage integrase, N-terminal Aminotran_1_2 PF00155.21 EXF82274.1 - 2e-87 293.8 0.0 2.2e-87 293.6 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Sugar_tr PF00083.24 EXF82275.1 - 3.5e-81 273.4 21.3 4e-81 273.2 21.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF82275.1 - 3e-24 85.6 22.2 3e-24 85.6 22.2 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EXF82275.1 - 0.0012 17.4 1.1 0.0018 16.8 1.1 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Gate PF07670.14 EXF82275.1 - 0.51 10.6 9.5 17 5.7 0.1 3.6 1 1 2 3 3 3 0 Nucleoside recognition Ank_2 PF12796.7 EXF82276.1 - 4e-70 232.4 9.8 2.6e-14 53.6 0.2 8.7 2 1 5 9 9 9 9 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EXF82276.1 - 1.6e-55 184.8 18.7 2e-10 41.0 0.1 12.5 5 3 9 14 14 14 13 Ankyrin repeats (many copies) Ank PF00023.30 EXF82276.1 - 4e-48 159.8 28.0 0.00015 22.0 0.0 15.4 14 1 1 15 15 15 11 Ankyrin repeat Ank_5 PF13857.6 EXF82276.1 - 1.2e-45 153.0 25.8 1.3e-06 28.6 0.0 13.1 5 3 9 14 14 14 10 Ankyrin repeats (many copies) Ank_3 PF13606.6 EXF82276.1 - 8e-44 142.6 19.0 0.0016 18.8 0.0 16.8 17 0 0 17 17 16 10 Ankyrin repeat ZZ PF00569.17 EXF82276.1 - 5.5e-06 26.1 7.7 1.9e-05 24.4 7.7 1.9 1 0 0 1 1 1 1 Zinc finger, ZZ type NACHT PF05729.12 EXF82276.1 - 2e-05 24.5 0.0 4.3e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_33 PF13671.6 EXF82276.1 - 0.0045 17.2 0.0 0.017 15.3 0.0 2.0 2 0 0 2 2 2 1 AAA domain C1_2 PF03107.16 EXF82276.1 - 0.0056 17.0 2.9 0.012 15.9 2.9 1.5 1 0 0 1 1 1 1 C1 domain RNA_helicase PF00910.22 EXF82276.1 - 0.0095 16.3 0.0 0.023 15.1 0.0 1.6 1 0 0 1 1 1 1 RNA helicase AAA_22 PF13401.6 EXF82276.1 - 0.01 16.1 0.0 0.076 13.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 EXF82276.1 - 0.05 14.0 0.0 0.19 12.1 0.0 2.0 1 0 0 1 1 1 0 AAA ATPase domain NB-ARC PF00931.22 EXF82276.1 - 0.08 12.1 0.0 0.15 11.2 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain Goodbye PF17109.5 EXF82276.1 - 0.12 12.8 0.0 0.35 11.3 0.0 1.8 1 0 0 1 1 1 0 fungal STAND N-terminal Goodbye domain p450 PF00067.22 EXF82277.1 - 1.7e-43 149.0 0.0 5.3e-32 111.2 0.0 2.6 2 1 0 2 2 2 2 Cytochrome P450 F-box-like PF12937.7 EXF82278.1 - 0.018 14.9 0.0 0.043 13.7 0.0 1.7 1 0 0 1 1 1 0 F-box-like LRR_2 PF07723.13 EXF82278.1 - 0.16 12.7 1.7 57 4.6 0.1 4.0 4 0 0 4 4 4 0 Leucine Rich Repeat LRR_4 PF12799.7 EXF82278.1 - 1 9.9 3.2 1.4 9.4 1.0 2.5 2 1 1 3 3 3 0 Leucine Rich repeats (2 copies) Lactonase PF10282.9 EXF82279.1 - 9e-22 77.8 5.6 4.4e-20 72.2 3.8 2.1 1 1 1 2 2 2 2 Lactonase, 7-bladed beta-propeller SGL PF08450.12 EXF82279.1 - 0.0025 17.4 0.5 0.0086 15.7 0.5 1.9 1 1 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region CorA PF01544.18 EXF82280.1 - 0.00068 19.0 0.0 0.0017 17.7 0.0 1.6 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein PetM PF08041.11 EXF82280.1 - 0.18 11.4 0.6 0.36 10.5 0.6 1.5 1 0 0 1 1 1 0 PetM family of cytochrome b6f complex subunit 7 ADH_N PF08240.12 EXF82281.1 - 7.5e-14 51.5 0.2 2e-13 50.2 0.2 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EXF82281.1 - 1.6e-05 24.9 0.2 7.7e-05 22.7 0.2 2.0 1 1 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EXF82281.1 - 0.0035 16.9 0.0 0.0055 16.2 0.0 1.3 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus AlaDh_PNT_C PF01262.21 EXF82281.1 - 0.0079 15.5 0.8 0.012 14.9 0.8 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain HI0933_like PF03486.14 EXF82281.1 - 0.018 13.8 0.0 0.025 13.3 0.0 1.2 1 0 0 1 1 1 0 HI0933-like protein AA_permease_2 PF13520.6 EXF82282.1 - 1.4e-60 205.3 54.2 1.8e-60 205.0 54.2 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EXF82282.1 - 4.2e-27 94.9 47.0 5.8e-27 94.4 47.0 1.1 1 0 0 1 1 1 1 Amino acid permease MatE PF01554.18 EXF82284.1 - 5.4e-54 182.2 32.3 1.8e-34 118.7 11.5 2.1 2 0 0 2 2 2 2 MatE Como_SCP PF02248.16 EXF82284.1 - 0.042 13.4 0.1 0.078 12.5 0.1 1.3 1 0 0 1 1 1 0 Small coat protein DUF5389 PF17364.2 EXF82284.1 - 0.084 12.9 0.1 0.084 12.9 0.1 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5389) Polysacc_synt_C PF14667.6 EXF82284.1 - 0.38 10.8 36.6 0.019 15.1 13.2 4.6 3 2 1 4 4 4 0 Polysaccharide biosynthesis C-terminal domain HET PF06985.11 EXF82285.1 - 2.2e-07 31.3 0.2 4e-07 30.5 0.2 1.3 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) DUF1768 PF08719.11 EXF82288.1 - 3.5e-50 170.4 0.1 4.4e-50 170.1 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1768) E1-E2_ATPase PF00122.20 EXF82289.1 - 9.4e-39 132.8 7.6 2.7e-29 102.0 0.0 3.7 2 1 1 3 3 3 2 E1-E2 ATPase Cation_ATPase_C PF00689.21 EXF82289.1 - 4.3e-21 75.4 7.4 4.3e-21 75.4 7.4 2.6 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 EXF82289.1 - 6.2e-19 69.1 0.0 1.5e-14 54.8 0.0 2.8 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EXF82289.1 - 1.7e-15 56.8 0.0 3.4e-15 55.9 0.0 1.4 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 EXF82289.1 - 4.4e-14 51.9 2.7 4.5e-14 51.9 0.1 2.5 3 0 0 3 3 3 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EXF82289.1 - 7e-06 26.0 0.2 1.3e-05 25.0 0.2 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF2463 PF09591.10 EXF82289.1 - 0.0085 16.0 1.2 0.051 13.4 0.9 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF2463) CoA_binding_3 PF13727.6 EXF82289.1 - 0.73 9.8 3.7 0.81 9.7 1.3 2.3 2 0 0 2 2 2 0 CoA-binding domain Glyco_hydro_cc PF11790.8 EXF82290.1 - 1.8e-21 76.8 0.1 2.2e-21 76.5 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core DEAD PF00270.29 EXF82291.1 - 1.8e-50 171.2 0.0 1e-49 168.7 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EXF82291.1 - 2.9e-26 92.0 0.0 2.2e-23 82.7 0.0 2.4 2 0 0 2 2 2 2 Helicase conserved C-terminal domain DBP10CT PF08147.12 EXF82291.1 - 4.1e-22 78.2 1.7 4.1e-22 78.2 1.7 2.2 2 0 0 2 2 2 1 DBP10CT (NUC160) domain DnaJ PF00226.31 EXF82292.1 - 1.2e-13 50.9 3.6 7.6e-13 48.4 0.3 2.9 3 0 0 3 3 3 1 DnaJ domain VIR_N PF15912.5 EXF82292.1 - 3 7.4 6.3 3.8 7.0 6.3 1.3 1 0 0 1 1 1 0 Virilizer, N-terminal ALMT PF11744.8 EXF82292.1 - 7.7 5.2 7.1 10 4.8 7.1 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Arm PF00514.23 EXF82293.1 - 1.1e-05 25.2 4.1 0.0068 16.4 0.4 4.2 4 0 0 4 4 4 2 Armadillo/beta-catenin-like repeat HEAT PF02985.22 EXF82293.1 - 0.03 14.6 0.4 0.52 10.7 0.0 3.5 3 0 0 3 3 3 0 HEAT repeat CNDH2_C PF16858.5 EXF82293.1 - 0.033 14.1 3.7 0.61 9.9 3.4 2.2 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term DNA_pol_phi PF04931.13 EXF82293.1 - 0.045 11.8 13.6 0.1 10.7 13.6 1.7 1 0 0 1 1 1 0 DNA polymerase phi Med25_SD1 PF11235.8 EXF82293.1 - 0.057 13.8 0.0 0.21 11.9 0.0 1.9 1 0 0 1 1 1 0 Mediator complex subunit 25 synapsin 1 RTP1_C1 PF10363.9 EXF82293.1 - 0.083 13.1 1.6 8.9 6.5 0.2 4.3 5 1 1 6 6 6 0 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_EZ PF13513.6 EXF82293.1 - 0.24 12.0 2.6 3.1 8.4 0.2 3.7 3 0 0 3 3 2 0 HEAT-like repeat Cwf_Cwc_15 PF04889.12 EXF82293.1 - 2 8.1 11.4 4 7.1 11.4 1.4 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein BUD22 PF09073.10 EXF82293.1 - 2.1 7.6 12.3 0.48 9.7 9.0 1.6 2 0 0 2 2 2 0 BUD22 SDA1 PF05285.12 EXF82293.1 - 2.2 7.6 12.4 3.5 6.9 12.4 1.2 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 EXF82293.1 - 4.6 5.3 13.8 7.7 4.6 13.8 1.3 1 0 0 1 1 1 0 Nop14-like family DUF202 PF02656.15 EXF82295.1 - 4e-17 62.4 5.8 2.2e-16 60.0 0.0 3.0 3 1 0 3 3 3 1 Domain of unknown function (DUF202) DUF1772 PF08592.11 EXF82295.1 - 0.02 15.2 2.0 0.62 10.4 2.1 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF1772) T4SS_CagC PF16943.5 EXF82295.1 - 0.03 14.5 1.9 0.062 13.5 1.3 1.9 2 1 0 2 2 2 0 Cag pathogenicity island, type IV secretory system DUF5305 PF17231.2 EXF82295.1 - 0.037 13.4 0.8 1.8 7.9 0.0 2.2 1 1 1 2 2 2 0 Family of unknown function (DUF5305) DUF2723 PF11028.8 EXF82295.1 - 0.055 13.4 0.9 1.5 8.7 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2723) COX4_pro_2 PF07835.12 EXF82295.1 - 0.11 12.6 0.0 0.11 12.6 0.0 2.3 3 0 0 3 3 3 0 Bacterial aa3 type cytochrome c oxidase subunit IV DUF1345 PF07077.11 EXF82295.1 - 0.12 12.1 3.9 3.4 7.4 2.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1345) Oxidored_q3 PF00499.20 EXF82295.1 - 0.15 11.7 3.0 1.3 8.8 3.0 2.0 1 1 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 DUF3290 PF11694.8 EXF82295.1 - 0.19 11.7 0.6 1.5 8.8 0.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3290) Ribosomal_L29e PF01779.17 EXF82296.1 - 0.24 11.7 0.0 0.47 10.8 0.0 1.4 1 0 0 1 1 1 0 Ribosomal L29e protein family Mlh1_C PF16413.5 EXF82298.1 - 2.8e-99 331.9 0.0 4.2e-99 331.3 0.0 1.3 1 0 0 1 1 1 1 DNA mismatch repair protein Mlh1 C-terminus DNA_mis_repair PF01119.19 EXF82298.1 - 2e-33 114.6 0.0 3.3e-33 113.9 0.0 1.4 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 EXF82298.1 - 9.8e-12 44.9 0.0 2e-11 43.8 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 EXF82298.1 - 3.8e-05 24.1 0.0 9.6e-05 22.9 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase NuDC PF16273.5 EXF82299.1 - 0.12 12.9 2.9 0.15 12.6 1.8 1.8 2 0 0 2 2 2 0 Nuclear distribution C domain Zn_clus PF00172.18 EXF82301.1 - 8.7e-07 29.0 11.7 1.4e-06 28.3 11.7 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PAS_4 PF08448.10 EXF82301.1 - 0.0025 18.1 0.0 0.0077 16.5 0.0 1.8 1 0 0 1 1 1 1 PAS fold PAS_11 PF14598.6 EXF82301.1 - 0.17 12.1 0.0 0.43 10.7 0.0 1.6 1 0 0 1 1 1 0 PAS domain Acetyltransf_8 PF13523.6 EXF82303.1 - 5.4e-46 155.9 3.0 8.3e-46 155.3 3.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 EXF82303.1 - 0.058 14.1 0.4 0.12 13.0 0.4 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Methyltransf_25 PF13649.6 EXF82304.1 - 3.9e-05 24.3 0.0 0.001 19.7 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain MetW PF07021.12 EXF82304.1 - 0.0041 16.8 0.0 0.12 11.9 0.0 2.2 2 0 0 2 2 2 1 Methionine biosynthesis protein MetW Methyltransf_11 PF08241.12 EXF82304.1 - 0.0097 16.5 0.0 1.3 9.7 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EXF82304.1 - 0.01 15.7 0.0 0.017 15.0 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain PCMT PF01135.19 EXF82304.1 - 0.011 15.5 0.0 0.018 14.8 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 EXF82304.1 - 0.017 14.9 0.0 0.37 10.6 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_24 PF13578.6 EXF82304.1 - 0.03 15.3 0.0 0.09 13.8 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain AMP-binding PF00501.28 EXF82305.1 - 5.7e-99 331.6 0.0 7.1e-99 331.3 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EXF82305.1 - 2.1e-13 51.0 0.0 4.8e-13 49.9 0.0 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain PB1 PF00564.24 EXF82305.1 - 0.2 11.6 0.0 0.49 10.4 0.0 1.6 1 0 0 1 1 1 0 PB1 domain Acetyltransf_1 PF00583.25 EXF82306.1 - 6.1e-08 32.9 0.1 8.6e-08 32.4 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EXF82306.1 - 1e-07 32.3 0.0 2.1e-07 31.3 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EXF82306.1 - 1.3e-06 28.3 0.0 3.3e-06 27.1 0.0 1.6 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EXF82306.1 - 0.01 15.8 0.1 0.09 12.8 0.1 2.1 1 1 0 1 1 1 0 FR47-like protein Acetyltransf_9 PF13527.7 EXF82306.1 - 0.036 14.1 0.1 0.12 12.4 0.0 1.8 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EXF82306.1 - 0.14 12.3 0.0 0.31 11.2 0.0 1.6 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase AA_permease PF00324.21 EXF82307.1 - 3.5e-95 319.4 34.1 4e-95 319.2 34.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EXF82307.1 - 1.7e-24 86.5 39.1 2.1e-24 86.2 39.1 1.0 1 0 0 1 1 1 1 Amino acid permease Inositol_P PF00459.25 EXF82308.1 - 3.7e-34 118.5 0.0 1.1e-33 116.9 0.0 1.7 1 1 0 1 1 1 1 Inositol monophosphatase family CVNH PF08881.10 EXF82309.1 - 1.4e-13 51.4 0.7 1.7e-13 51.1 0.7 1.1 1 0 0 1 1 1 1 CVNH domain Rad4 PF03835.15 EXF82310.1 - 2.3e-14 53.3 0.9 4.5e-14 52.4 0.9 1.5 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain Transglut_core PF01841.19 EXF82310.1 - 1.7e-11 44.5 1.5 4.1e-11 43.3 1.5 1.6 1 0 0 1 1 1 1 Transglutaminase-like superfamily WD40 PF00400.32 EXF82311.1 - 3.7e-11 43.4 8.7 1.7 9.7 0.0 8.8 10 0 0 10 10 10 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EXF82311.1 - 9.6e-06 25.8 0.8 3.3 8.1 0.1 5.9 6 1 0 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain PQQ PF01011.21 EXF82311.1 - 0.08 12.9 0.3 0.68 10.0 0.1 2.7 2 0 0 2 2 2 0 PQQ enzyme repeat RAB3GAP2_N PF14655.6 EXF82311.1 - 0.086 12.1 0.2 18 4.4 0.0 3.1 2 1 1 3 3 3 0 Rab3 GTPase-activating protein regulatory subunit N-terminus PQQ_2 PF13360.6 EXF82311.1 - 0.09 12.4 0.1 0.09 12.4 0.1 3.4 3 1 2 5 5 5 0 PQQ-like domain SDA1 PF05285.12 EXF82311.1 - 0.66 9.3 10.3 1.1 8.6 3.0 2.1 2 0 0 2 2 2 0 SDA1 Cwf_Cwc_15 PF04889.12 EXF82311.1 - 2.2 8.0 15.4 5.1 6.8 3.1 2.2 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein NAPRTase PF04095.16 EXF82312.1 - 1.6e-59 201.5 0.3 7.1e-31 107.7 0.3 2.2 2 0 0 2 2 2 2 Nicotinate phosphoribosyltransferase (NAPRTase) family NAPRTase_N PF17767.1 EXF82312.1 - 5.6e-36 123.7 0.1 9.9e-36 122.9 0.1 1.4 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain WSC PF01822.19 EXF82313.1 - 2.1e-18 66.3 5.7 3.9e-18 65.4 5.7 1.5 1 0 0 1 1 1 1 WSC domain COesterase PF00135.28 EXF82314.1 - 5.5e-75 253.2 0.0 8.5e-75 252.6 0.0 1.2 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EXF82314.1 - 1.7e-06 28.0 0.1 3.7e-06 26.9 0.1 1.6 1 0 0 1 1 1 1 alpha/beta hydrolase fold FAM199X PF15814.5 EXF82315.1 - 3.1 6.8 12.3 0.029 13.4 4.4 1.6 2 0 0 2 2 2 0 Protein family FAM199X AF-4 PF05110.13 EXF82315.1 - 3.2 5.7 7.3 3.8 5.5 7.3 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Glyco_hydro_18 PF00704.28 EXF82317.1 - 7.2e-20 71.9 0.1 1e-19 71.5 0.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Sporozoite_P67 PF05642.11 EXF82317.1 - 0.74 7.8 2.4 0.99 7.4 2.4 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Abhydrolase_6 PF12697.7 EXF82318.1 - 2.6e-09 38.0 1.7 3.8e-08 34.2 0.7 2.1 2 0 0 2 2 2 1 Alpha/beta hydrolase family ADH_N PF08240.12 EXF82318.1 - 6.2e-08 32.5 0.0 1.3e-07 31.5 0.0 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Abhydrolase_1 PF00561.20 EXF82318.1 - 8.3e-08 32.2 0.4 8.7e-07 28.8 0.4 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold ADH_zinc_N_2 PF13602.6 EXF82318.1 - 9e-05 23.5 0.0 0.00051 21.1 0.0 2.1 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Hydrolase_4 PF12146.8 EXF82318.1 - 0.0023 17.2 0.0 0.01 15.1 0.0 1.9 2 0 0 2 2 2 1 Serine aminopeptidase, S33 SnoaL_2 PF12680.7 EXF82318.1 - 0.1 13.3 0.1 0.2 12.3 0.1 1.5 1 0 0 1 1 1 0 SnoaL-like domain DUF1057 PF06342.12 EXF82318.1 - 0.14 11.2 0.0 0.3 10.1 0.0 1.5 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF1057) Methyltransf_23 PF13489.6 EXF82319.1 - 4.6e-24 85.1 0.0 6.5e-24 84.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF82319.1 - 2.4e-12 47.4 0.0 6.6e-12 46.0 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF82319.1 - 1.5e-11 44.4 0.1 1.7e-10 40.9 0.1 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF82319.1 - 2e-09 38.0 0.0 3.8e-09 37.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF82319.1 - 4.4e-08 33.8 0.1 5.8e-07 30.2 0.0 2.6 2 1 0 2 2 2 1 Methyltransferase domain PrmA PF06325.13 EXF82319.1 - 0.00035 20.1 0.0 0.00062 19.2 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 EXF82319.1 - 0.0051 16.4 0.0 0.009 15.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain DUF4440 PF14534.6 EXF82319.1 - 0.046 14.1 0.0 1.9 8.9 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4440) CMAS PF02353.20 EXF82319.1 - 0.058 12.7 0.0 0.078 12.3 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase DREV PF05219.12 EXF82319.1 - 0.15 11.1 0.0 0.22 10.6 0.0 1.1 1 0 0 1 1 1 0 DREV methyltransferase Ubie_methyltran PF01209.18 EXF82319.1 - 0.19 11.0 0.0 1.6 8.0 0.0 2.4 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family PCMT PF01135.19 EXF82319.1 - 0.21 11.3 0.0 0.49 10.1 0.0 1.7 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_4 PF02390.17 EXF82319.1 - 0.82 9.1 2.1 2.4 7.6 0.0 2.4 3 0 0 3 3 3 0 Putative methyltransferase DNase_NucA_NucB PF14040.6 EXF82320.1 - 0.019 15.3 0.7 0.088 13.2 0.0 2.4 2 0 0 2 2 2 0 Deoxyribonuclease NucA/NucB zf-RanBP PF00641.18 EXF82322.1 - 0.051 12.9 1.5 0.051 12.9 1.5 2.0 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others SesA PF17107.5 EXF82323.1 - 0.0054 16.9 0.5 0.034 14.3 0.3 2.1 2 0 0 2 2 2 1 N-terminal domain on NACHT_NTPase and P-loop NTPases Helo_like_N PF17111.5 EXF82323.1 - 0.013 14.9 0.3 0.026 13.9 0.3 1.5 1 0 0 1 1 1 0 Fungal N-terminal domain of STAND proteins Rx_N PF18052.1 EXF82323.1 - 0.054 13.8 1.5 0.14 12.4 1.5 1.7 1 0 0 1 1 1 0 Rx N-terminal domain Fmp27_WPPW PF10359.9 EXF82323.1 - 0.063 12.1 0.6 0.091 11.6 0.6 1.1 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain DUF2312 PF10073.9 EXF82323.1 - 0.39 10.4 2.6 0.61 9.8 0.5 2.1 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2312) Mpv17_PMP22 PF04117.12 EXF82324.1 - 2.8e-24 85.1 0.3 5e-24 84.3 0.3 1.4 1 0 0 1 1 1 1 Mpv17 / PMP22 family DUF1713 PF08213.11 EXF82325.1 - 1.5e-09 37.6 22.2 1.5e-09 37.6 22.2 1.8 2 0 0 2 2 2 1 Mitochondrial domain of unknown function (DUF1713) PhyH PF05721.13 EXF82325.1 - 3.7e-08 33.9 0.0 5.1e-06 26.9 0.0 3.3 2 1 0 2 2 2 1 Phytanoyl-CoA dioxygenase (PhyH) Pet20 PF08692.10 EXF82325.1 - 0.014 16.1 0.0 0.042 14.6 0.0 1.8 1 0 0 1 1 1 0 Mitochondrial protein Pet20 NLPC_P60 PF00877.19 EXF82325.1 - 0.054 13.5 0.0 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 NlpC/P60 family GNAT_acetyltr_2 PF13718.6 EXF82326.1 - 1.1e-95 319.4 0.0 2.1e-95 318.5 0.0 1.5 1 0 0 1 1 1 1 GNAT acetyltransferase 2 tRNA_bind_2 PF13725.6 EXF82326.1 - 1.5e-92 309.6 0.0 2.7e-92 308.8 0.0 1.5 1 0 0 1 1 1 1 Possible tRNA binding domain Helicase_RecD PF05127.14 EXF82326.1 - 5.3e-66 221.8 0.0 2.9e-65 219.4 0.0 2.3 3 0 0 3 3 3 1 Helicase DUF1726 PF08351.11 EXF82326.1 - 7.7e-34 115.5 0.0 2.1e-33 114.1 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1726) AAA_30 PF13604.6 EXF82326.1 - 9.6e-05 22.2 0.2 0.0064 16.2 0.1 2.6 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EXF82326.1 - 0.0013 19.0 0.0 0.072 13.4 0.0 2.9 2 0 0 2 2 2 1 AAA domain GHMP_kinases_N PF00288.26 EXF82326.1 - 0.072 13.3 0.1 0.18 12.0 0.1 1.7 1 0 0 1 1 1 0 GHMP kinases N terminal domain DUF4448 PF14610.6 EXF82328.1 - 1.2e-42 145.9 0.0 1.6e-42 145.5 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) G_path_suppress PF15991.5 EXF82330.1 - 4.6 7.3 7.2 5.1 7.2 7.2 1.0 1 0 0 1 1 1 0 G-protein pathway suppressor PROCN PF08083.11 EXF82331.1 - 1.4e-233 774.9 9.4 1.4e-233 774.9 9.4 1.9 2 0 0 2 2 2 1 PROCN (NUC071) domain PRP8_domainIV PF12134.8 EXF82331.1 - 6e-128 425.2 1.1 1.3e-127 424.1 1.1 1.6 1 0 0 1 1 1 1 PRP8 domain IV core U6-snRNA_bdg PF10596.9 EXF82331.1 - 5.7e-89 296.1 1.8 1.8e-88 294.5 1.8 2.0 1 0 0 1 1 1 1 U6-snRNA interacting domain of PrP8 PRO8NT PF08082.11 EXF82331.1 - 9.3e-78 259.4 3.3 9.3e-78 259.4 3.3 2.0 2 0 0 2 2 2 1 PRO8NT (NUC069), PrP8 N-terminal domain U5_2-snRNA_bdg PF10597.9 EXF82331.1 - 3.8e-71 237.4 0.1 7.7e-71 236.4 0.1 1.6 1 0 0 1 1 1 1 U5-snRNA binding site 2 of PrP8 RRM_4 PF10598.9 EXF82331.1 - 1.4e-46 156.7 0.1 4.2e-46 155.2 0.1 1.9 1 0 0 1 1 1 1 RNA recognition motif of the spliceosomal PrP8 PROCT PF08084.11 EXF82331.1 - 1e-44 151.4 0.5 2.6e-44 150.1 0.0 2.0 2 0 0 2 2 2 1 PROCT (NUC072) domain eIF-3c_N PF05470.12 EXF82332.1 - 5e-178 593.1 23.6 5e-178 593.1 23.6 3.0 1 1 1 2 2 2 1 Eukaryotic translation initiation factor 3 subunit 8 N-terminus PCI PF01399.27 EXF82332.1 - 2.8e-14 53.5 0.2 1.4e-13 51.3 0.2 2.4 1 0 0 1 1 1 1 PCI domain DUF2779 PF11074.8 EXF82332.1 - 0.13 12.7 3.5 1.3 9.5 0.1 3.6 3 1 0 3 3 3 0 Domain of unknown function(DUF2779) DASH_Ask1 PF08655.10 EXF82332.1 - 0.17 11.8 0.5 0.59 10.1 0.1 2.2 2 0 0 2 2 2 0 DASH complex subunit Ask1 PSII_Pbs27 PF13326.6 EXF82332.1 - 0.78 10.1 6.0 0.55 10.6 2.6 2.4 1 1 1 2 2 2 0 Photosystem II Pbs27 Hemerythrin PF01814.23 EXF82335.1 - 3.3e-11 43.9 3.6 4.5e-11 43.5 3.6 1.2 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain DUF4246 PF14033.6 EXF82336.1 - 2.8e-171 570.6 0.0 3.3e-171 570.4 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF4246) HTH_33 PF13592.6 EXF82336.1 - 0.032 13.9 0.5 0.44 10.2 0.0 2.8 3 0 0 3 3 3 0 Winged helix-turn helix PS_Dcarbxylase PF02666.15 EXF82337.1 - 1.7e-36 125.7 0.0 7.3e-36 123.6 0.0 1.9 1 1 0 1 1 1 1 Phosphatidylserine decarboxylase PSDC PF12588.8 EXF82337.1 - 3.4e-33 114.6 0.0 4.9e-33 114.0 0.0 1.2 1 0 0 1 1 1 1 Phophatidylserine decarboxylase RnfC_N PF13375.6 EXF82337.1 - 0.0063 16.5 0.2 2.9 7.9 0.0 3.2 4 0 0 4 4 4 2 RnfC Barrel sandwich hybrid domain Vps54_N PF10475.9 EXF82337.1 - 0.23 10.7 0.1 0.32 10.2 0.1 1.1 1 0 0 1 1 1 0 Vacuolar-sorting protein 54, of GARP complex DUF2706 PF10913.8 EXF82337.1 - 0.28 11.1 0.7 0.66 9.9 0.7 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2706) HET PF06985.11 EXF82338.1 - 1.3e-38 132.6 0.0 3.5e-32 111.8 0.0 2.3 2 0 0 2 2 2 2 Heterokaryon incompatibility protein (HET) Lactonase PF10282.9 EXF82339.1 - 1.3e-67 228.5 0.0 1.7e-67 228.1 0.0 1.0 1 0 0 1 1 1 1 Lactonase, 7-bladed beta-propeller FAD_binding_4 PF01565.23 EXF82340.1 - 3.1e-17 62.6 0.0 2.1e-16 59.9 0.1 2.3 2 0 0 2 2 2 1 FAD binding domain BBE PF08031.12 EXF82340.1 - 3.8e-13 49.3 0.0 7e-13 48.5 0.0 1.5 1 0 0 1 1 1 1 Berberine and berberine like Cytokin-bind PF09265.10 EXF82340.1 - 0.17 11.2 0.0 0.3 10.5 0.0 1.2 1 0 0 1 1 1 0 Cytokinin dehydrogenase 1, FAD and cytokinin binding Glyco_hydro_43 PF04616.14 EXF82341.1 - 7.4e-107 357.0 0.5 1.2e-106 356.2 0.5 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 GH43_C2 PF17851.1 EXF82341.1 - 2.4e-46 158.0 0.0 3.5e-46 157.5 0.0 1.2 1 0 0 1 1 1 1 Beta xylosidase C-terminal Concanavalin A-like domain DUF1653 PF07866.11 EXF82342.1 - 0.048 14.0 0.0 0.048 14.0 0.0 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1653) ADH_N PF08240.12 EXF82343.1 - 5.3e-22 77.8 2.6 9.8e-22 76.9 2.6 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EXF82343.1 - 1.9e-15 57.0 0.0 5.7e-15 55.4 0.0 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EXF82343.1 - 0.0014 19.7 0.0 0.0029 18.7 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ATPgrasp_N PF18130.1 EXF82343.1 - 0.0045 17.5 0.0 0.0089 16.6 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp N-terminal domain XdhC_C PF13478.6 EXF82343.1 - 0.01 16.4 0.0 0.024 15.2 0.0 1.7 1 0 0 1 1 1 0 XdhC Rossmann domain 2-Hacid_dh_C PF02826.19 EXF82343.1 - 0.012 15.0 0.0 0.021 14.2 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 EXF82343.1 - 0.031 13.6 0.1 0.084 12.2 0.1 1.7 1 1 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain DIOX_N PF14226.6 EXF82344.1 - 5.3e-19 69.1 0.0 8.5e-19 68.4 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EXF82344.1 - 2.1e-17 63.5 0.0 7.4e-17 61.7 0.0 1.9 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Glyco_hydro_38N PF01074.22 EXF82344.1 - 0.019 14.3 0.0 0.028 13.8 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolases family 38 N-terminal domain Transp_cyt_pur PF02133.15 EXF82345.1 - 1.4e-59 202.1 18.5 1.6e-59 201.9 18.5 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin DUF3990 PF13151.6 EXF82347.1 - 0.21 11.3 0.0 0.33 10.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3990) DUF1768 PF08719.11 EXF82348.1 - 2e-50 171.2 0.2 2.3e-50 171.0 0.2 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1768) NAD_binding_1 PF00175.21 EXF82349.1 - 5.1e-32 110.8 0.0 8.2e-32 110.1 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 EXF82349.1 - 3.6e-27 94.6 0.0 5.9e-27 93.9 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain Cyt-b5 PF00173.28 EXF82349.1 - 1.3e-22 79.7 0.6 2.9e-22 78.6 0.3 1.8 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain NAD_binding_6 PF08030.12 EXF82349.1 - 2.8e-05 24.3 0.0 0.002 18.3 0.0 2.2 2 0 0 2 2 2 1 Ferric reductase NAD binding domain FAD_binding_9 PF08021.11 EXF82349.1 - 0.0031 17.7 0.0 0.0097 16.1 0.0 1.9 1 1 0 1 1 1 1 Siderophore-interacting FAD-binding domain p450 PF00067.22 EXF82350.1 - 1.7e-69 234.8 0.0 2e-69 234.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 adh_short PF00106.25 EXF82351.1 - 4.1e-34 117.7 0.2 5.7e-34 117.3 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF82351.1 - 3.4e-28 98.8 0.1 4.1e-27 95.2 0.1 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF82351.1 - 3.5e-07 30.3 0.0 5.5e-07 29.7 0.0 1.3 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EXF82351.1 - 0.0073 15.5 0.0 0.01 15.0 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Shikimate_DH PF01488.20 EXF82351.1 - 0.12 12.4 0.2 0.38 10.8 0.1 1.8 1 1 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase adh_short PF00106.25 EXF82352.1 - 8.4e-26 90.6 0.3 6.1e-22 78.0 0.1 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EXF82352.1 - 9.3e-16 58.1 1.3 1.4e-14 54.2 1.3 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF82352.1 - 6.6e-06 26.2 0.2 1.2e-05 25.3 0.2 1.4 1 0 0 1 1 1 1 KR domain GDP_Man_Dehyd PF16363.5 EXF82352.1 - 0.016 14.6 0.8 0.19 11.1 0.8 2.1 1 1 0 1 1 1 0 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 EXF82352.1 - 0.076 12.5 1.8 0.19 11.1 0.4 2.2 1 1 1 2 2 2 0 NAD dependent epimerase/dehydratase family DUF2678 PF10856.8 EXF82353.1 - 0.02 14.9 8.3 0.64 10.0 0.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2678) HTH_OrfB_IS605 PF12323.8 EXF82353.1 - 0.16 11.5 0.2 0.34 10.4 0.2 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain SelK_SelG PF10961.8 EXF82353.1 - 0.55 10.9 2.9 3.3 8.4 2.9 2.2 1 1 0 1 1 1 0 Selenoprotein SelK_SelG LCM PF04072.14 EXF82354.1 - 1.9e-18 67.1 0.0 2.6e-18 66.6 0.0 1.1 1 0 0 1 1 1 1 Leucine carboxyl methyltransferase UbiA PF01040.18 EXF82355.1 - 1e-31 110.2 12.2 1.3e-31 109.8 12.2 1.2 1 0 0 1 1 1 1 UbiA prenyltransferase family Ndc80_HEC PF03801.13 EXF82355.1 - 0.18 11.4 0.0 0.36 10.4 0.0 1.4 1 0 0 1 1 1 0 HEC/Ndc80p family ABC_tran PF00005.27 EXF82356.1 - 5.7e-36 124.0 0.0 1.9e-35 122.3 0.0 2.0 2 0 0 2 2 2 1 ABC transporter ABC_membrane PF00664.23 EXF82356.1 - 1e-31 110.6 9.8 1e-31 110.6 9.8 2.0 3 0 0 3 3 3 1 ABC transporter transmembrane region SMC_N PF02463.19 EXF82356.1 - 1.9e-06 27.5 0.5 0.00055 19.4 0.0 2.4 1 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 EXF82356.1 - 0.0004 20.7 0.2 0.0019 18.5 0.2 2.1 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.6 EXF82356.1 - 0.0024 17.6 0.0 0.0044 16.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 EXF82356.1 - 0.0033 17.1 0.3 0.0086 15.8 0.3 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 EXF82356.1 - 0.017 15.5 0.8 0.16 12.4 0.8 2.2 1 1 0 1 1 1 0 AAA ATPase domain AAA_15 PF13175.6 EXF82356.1 - 0.02 14.6 0.0 0.033 13.9 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain SbcCD_C PF13558.6 EXF82356.1 - 0.034 14.4 0.4 0.46 10.8 0.4 2.6 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_10 PF12846.7 EXF82356.1 - 0.048 12.6 0.1 0.092 11.6 0.1 1.5 1 1 0 1 1 1 0 AAA-like domain AAA_21 PF13304.6 EXF82356.1 - 0.058 13.2 0.1 0.45 10.3 0.0 2.2 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 EXF82356.1 - 0.11 12.3 0.0 0.31 10.9 0.0 1.7 1 0 0 1 1 1 0 RsgA GTPase DUF87 PF01935.17 EXF82356.1 - 0.17 12.0 0.4 0.36 10.9 0.1 1.6 2 0 0 2 2 2 0 Helicase HerA, central domain ATP-synt_ab PF00006.25 EXF82356.1 - 0.17 11.5 0.0 4.8 6.8 0.0 2.4 2 1 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain Alpha-amylase PF00128.24 EXF82360.1 - 1.1e-22 81.1 1.8 2.1e-22 80.2 1.8 1.4 1 0 0 1 1 1 1 Alpha amylase, catalytic domain Glyco_hydro_70 PF02324.16 EXF82360.1 - 0.00036 18.9 0.6 0.38 8.9 0.0 3.0 2 1 1 3 3 3 3 Glycosyl hydrolase family 70 DUF1939 PF09154.10 EXF82360.1 - 0.0039 17.3 0.0 0.01 16.0 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1939) DUF647 PF04884.14 EXF82361.1 - 1.3e-90 303.3 0.1 1.8e-90 302.8 0.1 1.2 1 0 0 1 1 1 1 Vitamin B6 photo-protection and homoeostasis TauE PF01925.19 EXF82361.1 - 0.3 10.7 5.1 0.096 12.3 0.7 1.9 1 1 1 2 2 2 0 Sulfite exporter TauE/SafE AMP-binding PF00501.28 EXF82362.1 - 1.8e-86 290.4 0.0 6.1e-85 285.4 0.0 2.1 2 0 0 2 2 2 2 AMP-binding enzyme FtsX PF02687.21 EXF82362.1 - 1.1 9.8 8.1 0.2 12.1 3.6 2.1 2 0 0 2 2 2 0 FtsX-like permease family ECH_1 PF00378.20 EXF82363.1 - 6.3e-69 232.1 0.1 7.1e-69 231.9 0.1 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EXF82363.1 - 1.8e-31 109.9 0.4 1.4e-28 100.4 0.4 2.0 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase SDH_sah PF01972.16 EXF82363.1 - 0.045 12.7 0.1 0.11 11.5 0.1 1.4 1 1 0 1 1 1 0 Serine dehydrogenase proteinase DUF4449 PF14613.6 EXF82364.1 - 5.8e-05 23.2 0.1 0.00073 19.7 0.0 2.8 3 0 0 3 3 3 1 Protein of unknown function (DUF4449) Ank_2 PF12796.7 EXF82365.1 - 2.8e-78 258.5 7.8 9.7e-13 48.5 0.0 17.4 10 5 10 20 20 20 14 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EXF82365.1 - 1.8e-74 245.2 27.7 9.9e-07 29.2 0.0 26.1 19 7 9 28 28 28 15 Ankyrin repeats (many copies) Ank PF00023.30 EXF82365.1 - 2.3e-56 185.9 47.5 0.0015 18.9 0.0 24.3 24 2 0 24 24 24 15 Ankyrin repeat Ank_5 PF13857.6 EXF82365.1 - 1.4e-53 178.3 43.1 0.00023 21.4 0.0 21.4 17 6 6 23 23 23 15 Ankyrin repeats (many copies) Ank_3 PF13606.6 EXF82365.1 - 6.7e-53 170.5 26.0 0.0014 18.9 0.0 26.3 26 2 1 27 27 27 8 Ankyrin repeat NACHT PF05729.12 EXF82365.1 - 1.1e-08 35.1 0.0 4.5e-08 33.2 0.0 2.1 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 EXF82365.1 - 0.00018 21.9 0.0 0.0008 19.8 0.0 2.1 1 0 0 1 1 1 1 AAA ATPase domain DUF2075 PF09848.9 EXF82365.1 - 0.017 14.4 0.0 0.027 13.7 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) NB-ARC PF00931.22 EXF82365.1 - 0.047 12.9 0.0 0.1 11.8 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain RNA_helicase PF00910.22 EXF82365.1 - 0.21 12.0 0.0 0.58 10.6 0.0 1.8 1 0 0 1 1 1 0 RNA helicase Sugar_tr PF00083.24 EXF82366.1 - 1.8e-69 234.7 18.1 6.3e-55 186.8 5.5 2.0 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 EXF82366.1 - 8.4e-20 71.0 24.3 5.4e-18 65.0 13.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2236 PF09995.9 EXF82367.1 - 1.4e-07 32.0 0.5 3.1e-07 30.8 0.0 1.7 2 0 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2236) Aminotran_1_2 PF00155.21 EXF82368.1 - 8.9e-71 239.0 0.0 1e-70 238.8 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II AAA_16 PF13191.6 EXF82370.1 - 1.7e-06 28.5 0.2 2.9e-05 24.5 0.0 3.2 3 1 0 3 3 3 1 AAA ATPase domain NACHT PF05729.12 EXF82370.1 - 9.3e-06 25.7 0.1 0.00017 21.6 0.1 2.5 1 1 0 1 1 1 1 NACHT domain ABC_tran PF00005.27 EXF82370.1 - 0.0011 19.5 1.4 0.3 11.6 0.0 2.8 2 0 0 2 2 2 1 ABC transporter AAA_18 PF13238.6 EXF82370.1 - 0.02 15.4 0.0 0.34 11.5 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 EXF82370.1 - 0.027 14.2 0.2 0.065 13.0 0.2 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain RNA_helicase PF00910.22 EXF82370.1 - 0.032 14.6 0.0 0.074 13.5 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_22 PF13401.6 EXF82370.1 - 0.075 13.3 0.0 0.32 11.3 0.0 2.1 1 0 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.18 EXF82370.1 - 0.14 11.9 0.0 0.32 10.7 0.0 1.6 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_10 PF12846.7 EXF82370.1 - 0.31 9.9 2.2 8.4 5.2 0.1 2.8 3 0 0 3 3 3 0 AAA-like domain SlyX PF04102.12 EXF82370.1 - 5.2 7.8 5.3 3.4 8.4 0.3 3.1 2 0 0 2 2 2 0 SlyX adh_short PF00106.25 EXF82371.1 - 2.6e-19 69.5 0.0 1.6e-17 63.6 0.0 2.0 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EXF82371.1 - 6.5e-12 45.5 0.0 1.4e-10 41.1 0.0 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF82371.1 - 3.9e-05 23.6 0.0 5.6e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 KR domain Fumble PF03630.14 EXF82371.1 - 0.16 11.1 0.0 0.22 10.7 0.0 1.1 1 0 0 1 1 1 0 Fumble Sugar_tr PF00083.24 EXF82372.1 - 2.5e-82 277.2 22.8 3.4e-82 276.7 22.8 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF82372.1 - 2.8e-28 98.8 24.2 2.8e-28 98.8 24.2 1.9 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 EXF82372.1 - 1.9e-05 23.3 2.7 3.3e-05 22.5 2.7 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF1761 PF08570.10 EXF82372.1 - 0.37 11.0 12.8 0.82 9.9 6.8 3.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1761) MFS_1 PF07690.16 EXF82373.1 - 4.4e-27 94.9 24.5 4.4e-27 94.9 24.5 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily MFS_4 PF06779.14 EXF82373.1 - 9.4e-08 31.7 5.7 2.1e-07 30.6 5.7 1.5 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB Trp_oprn_chp PF09534.10 EXF82373.1 - 0.0069 16.2 0.0 3.3 7.5 0.0 2.3 2 0 0 2 2 2 2 Tryptophan-associated transmembrane protein (Trp_oprn_chp) DUF2575 PF10837.8 EXF82373.1 - 0.28 11.5 2.0 1.3 9.4 0.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2575) DUF485 PF04341.12 EXF82373.1 - 1.9 8.5 0.0 1.9 8.5 0.0 3.1 4 0 0 4 4 4 0 Protein of unknown function, DUF485 Fungal_trans PF04082.18 EXF82374.1 - 4.3e-22 78.4 0.4 5.8e-22 78.0 0.4 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain HpcH_HpaI PF03328.14 EXF82375.1 - 3.1e-31 108.2 0.0 3.9e-31 107.9 0.0 1.1 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family PEP-utilizers_C PF02896.18 EXF82375.1 - 3.1e-05 23.3 0.4 0.00052 19.2 0.3 2.5 2 2 1 3 3 3 1 PEP-utilising enzyme, TIM barrel domain 2-Hacid_dh_C PF02826.19 EXF82376.1 - 1.6e-46 157.9 0.0 2.3e-46 157.4 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EXF82376.1 - 7.4e-23 80.7 0.0 8.7e-23 80.5 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain AdoHcyase_NAD PF00670.21 EXF82376.1 - 0.00012 22.1 0.0 0.00025 21.2 0.0 1.4 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain SGL PF08450.12 EXF82377.1 - 2.3e-31 109.3 0.0 8.6e-25 87.7 0.0 2.2 1 1 1 2 2 2 2 SMP-30/Gluconolactonase/LRE-like region Fungal_trans PF04082.18 EXF82377.1 - 1.7e-12 47.0 1.2 2.8e-12 46.3 1.2 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain NHL PF01436.21 EXF82377.1 - 1.6e-07 31.0 0.3 0.33 11.1 0.0 5.4 6 0 0 6 6 6 2 NHL repeat Str_synth PF03088.16 EXF82377.1 - 2.7e-06 27.4 0.0 0.0021 18.2 0.0 3.5 3 1 0 3 3 3 1 Strictosidine synthase Arylesterase PF01731.20 EXF82377.1 - 0.0072 16.5 0.0 0.031 14.5 0.0 2.1 2 0 0 2 2 2 1 Arylesterase Lactonase PF10282.9 EXF82377.1 - 0.17 11.1 0.0 0.27 10.5 0.0 1.3 1 0 0 1 1 1 0 Lactonase, 7-bladed beta-propeller Sugar_tr PF00083.24 EXF82378.1 - 2.4e-38 132.2 22.8 5.8e-26 91.4 9.4 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 EXF82378.1 - 1.4e-05 24.2 23.9 0.0003 19.8 2.1 2.4 2 1 0 2 2 2 2 Major Facilitator Superfamily GST_C_3 PF14497.6 EXF82379.1 - 1.1e-32 112.2 0.0 1.8e-32 111.5 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EXF82379.1 - 2.5e-05 24.4 0.0 4.2e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EXF82379.1 - 0.00017 21.6 0.0 0.00039 20.4 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EXF82379.1 - 0.15 12.4 0.0 1.1 9.7 0.0 2.3 1 1 0 1 1 1 0 Glutathione S-transferase, N-terminal domain Mannitol_dh_C PF08125.13 EXF82382.1 - 3.5e-74 249.4 0.0 4.9e-74 248.9 0.0 1.2 1 0 0 1 1 1 1 Mannitol dehydrogenase C-terminal domain Mannitol_dh PF01232.23 EXF82382.1 - 9.3e-50 168.7 0.0 1.7e-49 167.9 0.0 1.5 1 0 0 1 1 1 1 Mannitol dehydrogenase Rossmann domain Tektin PF03148.14 EXF82384.1 - 0.0038 16.0 1.8 0.0038 16.0 1.8 1.5 1 1 0 1 1 1 1 Tektin family DUF1664 PF07889.12 EXF82384.1 - 0.0045 17.0 2.6 0.0063 16.5 0.7 2.2 1 1 1 2 2 2 1 Protein of unknown function (DUF1664) DUF4988 PF16378.5 EXF82384.1 - 0.0066 16.1 0.5 0.033 13.9 0.0 2.1 2 1 0 2 2 2 1 Domain of unknown function Snapin_Pallidin PF14712.6 EXF82384.1 - 0.022 15.1 1.2 0.083 13.3 0.0 2.4 3 0 0 3 3 3 0 Snapin/Pallidin Fib_alpha PF08702.10 EXF82384.1 - 0.026 14.7 1.9 0.04 14.1 0.4 1.9 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DUF4094 PF13334.6 EXF82384.1 - 0.057 13.8 0.5 0.29 11.6 0.0 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4094) Tropomyosin PF00261.20 EXF82384.1 - 0.072 12.4 5.9 0.13 11.7 5.9 1.5 1 1 0 1 1 1 0 Tropomyosin Bap31_Bap29_C PF18035.1 EXF82385.1 - 0.00051 20.0 8.5 0.2 11.7 2.2 3.7 2 1 1 3 3 3 2 Bap31/Bap29 cytoplasmic coiled-coil domain Fib_alpha PF08702.10 EXF82385.1 - 0.0047 17.1 8.3 0.014 15.6 5.4 2.4 2 0 0 2 2 2 1 Fibrinogen alpha/beta chain family DUF641 PF04859.12 EXF82385.1 - 0.016 15.6 3.1 0.016 15.6 3.1 2.5 1 1 2 3 3 3 0 Plant protein of unknown function (DUF641) DUF1664 PF07889.12 EXF82385.1 - 0.04 14.0 8.7 0.098 12.7 4.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) HATPase_c_2 PF13581.6 EXF82385.1 - 0.067 13.1 0.6 0.17 11.9 0.3 1.7 2 0 0 2 2 2 0 Histidine kinase-like ATPase domain DivIC PF04977.15 EXF82385.1 - 0.2 11.5 4.5 1.6 8.5 1.6 2.8 2 0 0 2 2 2 0 Septum formation initiator SlyX PF04102.12 EXF82385.1 - 0.22 12.1 9.2 0.68 10.6 2.5 2.8 1 1 1 2 2 2 0 SlyX Spectrin PF00435.21 EXF82385.1 - 0.22 12.0 0.3 0.22 12.0 0.3 3.0 2 1 0 2 2 2 0 Spectrin repeat KxDL PF10241.9 EXF82385.1 - 0.26 11.6 4.9 0.8 10.0 1.8 2.6 2 0 0 2 2 2 0 Uncharacterized conserved protein TolA_bind_tri PF16331.5 EXF82385.1 - 0.41 10.8 6.3 0.67 10.1 1.0 2.8 2 0 0 2 2 2 0 TolA binding protein trimerisation Prefoldin_2 PF01920.20 EXF82385.1 - 0.64 10.0 9.0 4.8 7.2 1.0 2.9 2 1 1 3 3 3 0 Prefoldin subunit T2SSM PF04612.12 EXF82385.1 - 1.3 9.1 7.6 0.68 10.0 2.2 2.7 2 1 1 3 3 3 0 Type II secretion system (T2SS), protein M DUF16 PF01519.16 EXF82385.1 - 1.8 9.1 9.8 0.62 10.6 4.8 2.6 1 1 2 3 3 3 0 Protein of unknown function DUF16 Sipho_Gp157 PF05565.11 EXF82385.1 - 4 7.4 11.8 0.55 10.2 0.9 2.7 2 1 0 2 2 2 0 Siphovirus Gp157 Swi5 PF07061.11 EXF82385.1 - 4.4 7.5 9.6 12 6.1 0.2 3.4 2 1 1 3 3 3 0 Swi5 SOGA PF11365.8 EXF82385.1 - 6.5 8.0 10.9 1.3 10.2 2.7 3.2 1 1 2 3 3 3 0 Protein SOGA DUF4446 PF14584.6 EXF82385.1 - 6.9 6.6 10.3 7.8 6.5 0.7 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF4446) ZapB PF06005.12 EXF82385.1 - 8.7 6.9 18.6 0.99 9.9 1.7 3.3 3 1 1 4 4 4 0 Cell division protein ZapB DUF16 PF01519.16 EXF82386.1 - 2 9.0 6.4 21 5.7 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function DUF16 DUF883 PF05957.13 EXF82386.1 - 2.5 8.8 8.3 7.9 7.2 0.9 2.6 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF883) Tannase PF07519.11 EXF82388.1 - 5.2e-12 45.4 0.0 6.8e-12 45.0 0.0 1.1 1 0 0 1 1 1 1 Tannase and feruloyl esterase Zn_clus PF00172.18 EXF82389.1 - 6.5e-07 29.4 9.7 1.2e-06 28.5 9.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain NmrA PF05368.13 EXF82390.1 - 2.7e-63 213.7 1.4 3.4e-63 213.3 1.4 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EXF82390.1 - 2.1e-21 76.7 1.4 4e-21 75.7 1.0 1.7 1 1 1 2 2 2 1 NAD(P)H-binding 3Beta_HSD PF01073.19 EXF82390.1 - 5e-05 22.4 0.2 6.9e-05 22.0 0.2 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EXF82390.1 - 0.014 14.9 0.3 0.027 13.9 0.3 1.6 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family TrkA_N PF02254.18 EXF82390.1 - 0.044 14.0 0.1 0.15 12.3 0.0 1.8 2 0 0 2 2 2 0 TrkA-N domain NmrA PF05368.13 EXF82391.1 - 1.4e-33 116.4 0.0 1.7e-33 116.1 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EXF82391.1 - 2.3e-11 43.9 0.0 3.1e-11 43.5 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EXF82391.1 - 0.00016 21.3 0.0 0.0016 18.0 0.0 2.0 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family KR PF08659.10 EXF82391.1 - 0.00064 19.7 0.1 0.0014 18.6 0.0 1.5 2 0 0 2 2 2 1 KR domain 3Beta_HSD PF01073.19 EXF82391.1 - 0.0019 17.3 0.0 0.0035 16.4 0.0 1.4 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family adh_short PF00106.25 EXF82391.1 - 0.0054 16.2 0.1 0.18 11.2 0.0 2.2 2 0 0 2 2 2 1 short chain dehydrogenase GDP_Man_Dehyd PF16363.5 EXF82391.1 - 0.0072 15.8 0.0 0.013 15.0 0.0 1.4 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase DapB_N PF01113.20 EXF82391.1 - 0.074 13.2 0.0 0.14 12.3 0.0 1.5 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus FAD_binding_3 PF01494.19 EXF82392.1 - 2.5e-17 63.2 2.2 3.1e-07 30.0 0.0 3.1 3 0 0 3 3 3 3 FAD binding domain DAO PF01266.24 EXF82392.1 - 6.6e-11 42.4 2.5 7.2e-07 29.1 0.5 2.3 1 1 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EXF82392.1 - 4.4e-07 29.4 2.3 1.8e-06 27.4 2.3 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EXF82392.1 - 7.7e-06 26.1 0.1 2e-05 24.7 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EXF82392.1 - 1.1e-05 24.8 0.0 1.9e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain AlaDh_PNT_C PF01262.21 EXF82392.1 - 0.00056 19.3 0.1 0.0011 18.4 0.1 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain HI0933_like PF03486.14 EXF82392.1 - 0.0046 15.7 0.2 0.0099 14.6 0.0 1.6 2 0 0 2 2 2 1 HI0933-like protein SE PF08491.10 EXF82392.1 - 0.0098 15.0 0.0 0.054 12.5 0.0 1.9 2 0 0 2 2 2 1 Squalene epoxidase GIDA PF01134.22 EXF82392.1 - 0.014 14.5 0.1 0.022 13.8 0.1 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A Trp_halogenase PF04820.14 EXF82392.1 - 0.015 14.2 1.2 0.21 10.4 0.1 2.4 2 0 0 2 2 2 0 Tryptophan halogenase Lycopene_cycl PF05834.12 EXF82392.1 - 0.023 13.7 0.2 0.45 9.5 0.0 2.4 3 0 0 3 3 3 0 Lycopene cyclase protein Pyr_redox PF00070.27 EXF82392.1 - 0.032 14.8 0.6 0.13 12.8 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase DSBA PF01323.20 EXF82392.1 - 0.045 13.5 0.0 0.087 12.6 0.0 1.4 1 0 0 1 1 1 0 DSBA-like thioredoxin domain UDPG_MGDP_dh_N PF03721.14 EXF82392.1 - 0.057 13.0 0.4 4.8 6.7 0.0 2.2 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_binding_7 PF13241.6 EXF82392.1 - 0.079 13.4 0.0 0.83 10.1 0.0 2.4 1 1 0 1 1 1 0 Putative NAD(P)-binding Thioredoxin_10 PF17991.1 EXF82392.1 - 0.082 13.5 0.0 0.16 12.5 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin like C-terminal domain TrkA_N PF02254.18 EXF82392.1 - 0.1 12.8 0.9 0.39 11.0 0.0 2.3 2 0 0 2 2 2 0 TrkA-N domain DUF2076 PF09849.9 EXF82393.1 - 1.1 9.3 5.7 0.15 12.1 2.0 1.4 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2076) adh_short PF00106.25 EXF82394.1 - 2.7e-37 128.1 0.1 1.3e-36 125.9 0.1 2.0 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF82394.1 - 1.8e-27 96.4 0.1 5e-27 95.0 0.1 1.7 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF82394.1 - 3.1e-06 27.2 0.1 3.5e-05 23.8 0.0 2.1 2 0 0 2 2 2 1 KR domain Polysacc_synt_2 PF02719.15 EXF82394.1 - 0.014 14.5 0.0 0.02 14.0 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Epimerase PF01370.21 EXF82394.1 - 0.093 12.2 0.0 0.29 10.6 0.0 1.7 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family Focadhesin PF11229.8 EXF82394.1 - 0.14 10.4 0.0 0.2 9.8 0.0 1.1 1 0 0 1 1 1 0 Focadhesin Methyltransf_25 PF13649.6 EXF82394.1 - 0.15 12.8 0.0 0.27 12.0 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain DUF4449 PF14613.6 EXF82395.1 - 1.8e-68 229.7 3.3 1.8e-68 229.7 3.3 2.3 2 1 0 2 2 2 1 Protein of unknown function (DUF4449) Prp18 PF02840.15 EXF82395.1 - 0.11 12.5 7.4 0.18 11.9 0.0 2.9 2 1 0 3 3 3 0 Prp18 domain YlqD PF11068.8 EXF82395.1 - 1.7 9.0 10.4 0.029 14.7 1.8 2.4 2 0 0 2 2 2 0 YlqD protein APH PF01636.23 EXF82396.1 - 1.5e-07 31.6 0.0 1.3e-06 28.6 0.0 2.1 1 1 0 1 1 1 1 Phosphotransferase enzyme family Arcadin_1 PF18653.1 EXF82396.1 - 0.11 12.6 0.0 0.29 11.2 0.0 1.7 1 0 0 1 1 1 0 Arcadin 1 Clr5 PF14420.6 EXF82397.1 - 7.3e-05 22.9 1.9 8.7e-05 22.7 0.1 2.1 2 0 0 2 2 2 1 Clr5 domain Herpes_US12 PF05363.12 EXF82397.1 - 0.25 12.1 3.9 0.2 12.4 1.2 2.2 2 0 0 2 2 2 0 Herpesvirus US12 family DUF5519 PF17648.1 EXF82398.1 - 0.074 12.9 0.2 0.15 11.9 0.2 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5519) Peptidase_M14 PF00246.24 EXF82399.1 - 1.2e-14 54.8 0.0 3.3e-14 53.4 0.0 1.6 1 1 1 2 2 2 1 Zinc carboxypeptidase AstE_AspA PF04952.14 EXF82399.1 - 0.037 13.1 0.1 0.083 11.9 0.0 1.6 2 0 0 2 2 2 0 Succinylglutamate desuccinylase / Aspartoacylase family MFS_1 PF07690.16 EXF82400.1 - 3.3e-17 62.4 40.8 4.5e-11 42.3 23.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF82400.1 - 2e-08 33.5 24.9 3e-07 29.7 24.6 2.8 1 1 0 1 1 1 1 Sugar (and other) transporter CBM_1 PF00734.18 EXF82400.1 - 0.069 13.1 0.1 0.14 12.2 0.1 1.5 1 0 0 1 1 1 0 Fungal cellulose binding domain IU_nuc_hydro PF01156.19 EXF82401.1 - 2e-15 57.1 0.0 2.7e-15 56.7 0.0 1.2 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase PTP_tm PF18861.1 EXF82402.1 - 0.0053 16.8 0.0 0.0094 16.0 0.0 1.4 1 0 0 1 1 1 1 Transmembrane domain of protein tyrosine phosphatase, receptor type J VSP PF03302.13 EXF82402.1 - 0.011 14.6 0.3 0.016 14.1 0.3 1.2 1 0 0 1 1 1 0 Giardia variant-specific surface protein Mucin15 PF15672.5 EXF82402.1 - 0.15 11.5 4.8 0.1 12.1 1.0 2.0 1 1 1 2 2 2 0 Cell-membrane associated Mucin15 DNA_ligase_A_M PF01068.21 EXF82403.1 - 3.8e-44 150.8 0.0 8.3e-44 149.7 0.0 1.6 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 EXF82403.1 - 8.9e-42 143.3 0.0 1.7e-41 142.4 0.0 1.5 1 0 0 1 1 1 1 DNA ligase N terminus BRCT_2 PF16589.5 EXF82403.1 - 1.8e-17 63.5 0.0 1.7e-09 38.0 0.0 2.4 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain RNA_ligase PF09414.10 EXF82403.1 - 3.4e-16 60.0 0.0 7.9e-16 58.8 0.0 1.7 1 0 0 1 1 1 1 RNA ligase DNA_ligase_A_C PF04679.15 EXF82403.1 - 6.9e-16 58.7 0.1 3e-15 56.6 0.0 2.3 2 0 0 2 2 2 1 ATP dependent DNA ligase C terminal region BRCT PF00533.26 EXF82403.1 - 1.2e-08 35.2 0.1 5.2e-06 26.8 0.0 3.2 3 1 0 3 3 3 1 BRCA1 C Terminus (BRCT) domain LIG3_BRCT PF16759.5 EXF82403.1 - 0.00014 22.1 0.1 0.017 15.4 0.0 2.5 2 0 0 2 2 2 1 DNA ligase 3 BRCT domain DNA_ligase_IV PF11411.8 EXF82403.1 - 0.0013 18.8 0.0 0.0025 17.9 0.0 1.5 1 0 0 1 1 1 1 DNA ligase IV RTT107_BRCT_5 PF16770.5 EXF82403.1 - 0.0052 16.6 0.1 0.96 9.4 0.0 2.8 3 0 0 3 3 3 1 Regulator of Ty1 transposition protein 107 BRCT domain mRNA_cap_enzyme PF01331.19 EXF82403.1 - 0.015 15.1 0.0 0.33 10.7 0.0 2.6 2 1 0 2 2 2 0 mRNA capping enzyme, catalytic domain UPRTase PF14681.6 EXF82404.1 - 8.9e-75 250.7 0.0 1e-74 250.5 0.0 1.0 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.27 EXF82404.1 - 0.0001 21.8 0.0 0.00017 21.1 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain NAD_binding_10 PF13460.6 EXF82404.1 - 0.0048 16.8 0.0 0.0075 16.2 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding TMP-TENI PF02581.17 EXF82404.1 - 0.014 14.8 0.1 0.17 11.2 0.1 2.2 2 0 0 2 2 2 0 Thiamine monophosphate synthase Peptidase_S13 PF02113.15 EXF82404.1 - 0.11 11.1 0.0 0.14 10.9 0.0 1.1 1 0 0 1 1 1 0 D-Ala-D-Ala carboxypeptidase 3 (S13) family CRCB PF02537.15 EXF82405.1 - 8.6e-38 128.6 17.8 8.1e-23 80.6 10.1 2.5 2 0 0 2 2 2 2 CrcB-like protein, Camphor Resistance (CrcB) Ribosomal_L13e PF01294.18 EXF82405.1 - 0.00046 20.1 1.1 0.014 15.3 0.0 2.4 2 1 1 3 3 3 1 Ribosomal protein L13e Phage_cap_P2 PF05125.12 EXF82405.1 - 0.06 12.3 0.0 2.3 7.2 0.0 2.1 2 0 0 2 2 2 0 Phage major capsid protein, P2 family BDV_G PF06208.11 EXF82406.1 - 0.07 12.3 0.0 0.12 11.5 0.0 1.2 1 0 0 1 1 1 0 Borna disease virus G protein DUF1404 PF07185.11 EXF82406.1 - 3 7.5 11.0 19 4.9 5.0 3.6 3 1 0 3 3 3 0 Protein of unknown function (DUF1404) zf-H2C2_2 PF13465.6 EXF82407.1 - 3.9e-18 65.0 18.8 8.8e-06 25.9 0.4 4.6 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2 PF00096.26 EXF82407.1 - 3.4e-17 61.9 24.2 2.8e-05 24.3 0.1 4.5 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EXF82407.1 - 5.2e-09 36.2 22.9 0.051 14.4 1.1 4.6 4 0 0 4 4 4 4 C2H2-type zinc finger FOXP-CC PF16159.5 EXF82407.1 - 2.5e-06 28.0 8.4 0.49 11.1 0.2 5.0 3 1 2 5 5 5 2 FOXP coiled-coil domain zf-C2H2_8 PF15909.5 EXF82407.1 - 0.0041 17.4 10.7 1.4 9.3 0.0 3.4 3 1 0 3 3 3 2 C2H2-type zinc ribbon zf-met PF12874.7 EXF82407.1 - 0.062 13.7 8.9 3 8.4 0.1 4.0 4 0 0 4 4 4 0 Zinc-finger of C2H2 type zf-TRAF PF02176.18 EXF82407.1 - 0.12 13.0 0.7 0.12 13.0 0.7 3.3 3 1 1 4 4 4 0 TRAF-type zinc finger zf-C2H2_jaz PF12171.8 EXF82407.1 - 2 8.8 9.4 3.8 7.9 0.3 3.8 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding FAD_binding_4 PF01565.23 EXF82408.1 - 6.2e-21 74.6 5.5 1e-20 73.9 5.5 1.4 1 0 0 1 1 1 1 FAD binding domain EthD PF07110.11 EXF82409.1 - 4.5e-13 50.2 0.1 5.4e-13 49.9 0.1 1.1 1 0 0 1 1 1 1 EthD domain MmlI PF09448.10 EXF82409.1 - 1.9e-05 25.1 0.0 2.6e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 Methylmuconolactone methyl-isomerase Usher_TcfC PF17271.2 EXF82409.1 - 0.013 14.3 0.0 0.017 14.0 0.0 1.1 1 0 0 1 1 1 0 TcfC Usher-like barrel domain Imm70 PF15601.6 EXF82409.1 - 0.071 12.7 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 Immunity protein 70 TRADD_N PF09034.10 EXF82409.1 - 0.11 12.6 0.0 0.14 12.2 0.0 1.2 1 0 0 1 1 1 0 TRADD, N-terminal domain peroxidase PF00141.23 EXF82410.1 - 5.1e-24 85.2 0.0 8e-24 84.6 0.0 1.3 1 0 0 1 1 1 1 Peroxidase Actino_peptide PF14408.6 EXF82410.1 - 0.35 11.0 1.9 0.82 9.8 0.3 2.3 2 0 0 2 2 2 0 Ribosomally synthesised peptide in actinomycetes S1 PF00575.23 EXF82411.1 - 3.2e-75 248.5 42.6 3.7e-14 52.8 1.0 13.2 13 0 0 13 13 13 11 S1 RNA binding domain S1_2 PF13509.6 EXF82411.1 - 1.7e-05 24.8 0.4 15 5.7 0.0 5.0 4 0 0 4 4 4 0 S1 domain TPR_19 PF14559.6 EXF82411.1 - 2.5e-05 24.7 1.3 0.85 10.2 0.0 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat RNase_II_C_S1 PF18614.1 EXF82411.1 - 4.6e-05 23.3 4.2 6.6 6.8 0.0 6.5 6 0 0 6 6 6 1 RNase II-type exonuclease C-terminal S1 domain TPR_14 PF13428.6 EXF82411.1 - 0.00014 22.4 1.8 5.4 8.1 0.0 5.0 3 1 2 5 5 5 2 Tetratricopeptide repeat RNase_H2_suC PF08615.11 EXF82411.1 - 0.025 14.8 0.2 0.64 10.2 0.0 3.0 2 1 0 2 2 2 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) NRDE-2 PF08424.10 EXF82411.1 - 0.026 13.6 4.1 0.053 12.6 0.6 2.4 1 1 1 2 2 2 0 NRDE-2, necessary for RNA interference PCB_OB PF17092.5 EXF82411.1 - 0.03 15.1 18.1 9.9 7.0 0.4 9.0 8 2 2 11 11 10 0 Penicillin-binding protein OB-like domain TPR_16 PF13432.6 EXF82411.1 - 0.04 14.6 0.3 15 6.3 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF2187 PF09953.9 EXF82411.1 - 0.054 13.5 1.0 2.3 8.3 0.0 3.8 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2187) AEP1 PF17049.5 EXF82411.1 - 0.072 12.2 0.1 0.12 11.4 0.1 1.3 1 0 0 1 1 1 0 ATPase expression protein 1 TPR_6 PF13174.6 EXF82411.1 - 0.13 12.9 0.4 22 6.0 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat Peptidase_M16_C PF05193.21 EXF82413.1 - 4.1e-59 199.7 0.0 6.9e-59 198.9 0.0 1.4 1 0 0 1 1 1 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EXF82413.1 - 3e-39 134.4 0.0 2.1e-38 131.6 0.0 2.0 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) FHA PF00498.26 EXF82414.1 - 4e-15 55.9 0.0 7.3e-15 55.1 0.0 1.5 1 0 0 1 1 1 1 FHA domain zf-RING_11 PF17123.5 EXF82414.1 - 7.6e-13 48.0 10.4 1.3e-12 47.2 10.4 1.4 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_2 PF13639.6 EXF82414.1 - 2.2e-06 27.9 13.0 3.7e-06 27.2 13.0 1.4 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 EXF82414.1 - 0.0096 16.2 8.7 0.027 14.7 8.7 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger domain Yop-YscD_cpl PF16697.5 EXF82414.1 - 0.013 15.8 0.0 0.029 14.7 0.0 1.5 1 0 0 1 1 1 0 Inner membrane component of T3SS, cytoplasmic domain zf-C3HC4 PF00097.25 EXF82414.1 - 0.013 15.3 12.8 0.023 14.6 12.8 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EXF82414.1 - 0.16 12.0 10.3 0.26 11.3 10.3 1.4 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_2 PF13923.6 EXF82414.1 - 0.19 11.6 11.9 0.37 10.7 11.9 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EXF82414.1 - 0.21 11.7 3.3 0.41 10.7 3.3 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 EXF82414.1 - 0.41 10.7 11.8 0.86 9.7 11.8 1.6 1 0 0 1 1 1 0 RING-type zinc-finger lci PF12197.8 EXF82414.1 - 0.76 9.6 2.4 0.75 9.6 0.8 1.8 2 0 0 2 2 2 0 Bacillus cereus group antimicrobial protein Vps16_C PF04840.12 EXF82415.1 - 9.1e-86 287.8 0.0 1.3e-85 287.3 0.0 1.2 1 0 0 1 1 1 1 Vps16, C-terminal region Vps16_N PF04841.13 EXF82415.1 - 1.1e-83 281.4 0.0 1.9e-83 280.5 0.0 1.4 1 1 0 1 1 1 1 Vps16, N-terminal region ANAPC4_WD40 PF12894.7 EXF82415.1 - 0.088 13.1 0.0 15 6.0 0.0 3.0 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain ATG16 PF08614.11 EXF82416.1 - 7.9e-57 192.7 28.2 8.8e-57 192.6 28.2 1.0 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) CCDC144C PF14915.6 EXF82416.1 - 0.0012 18.0 22.9 0.093 11.8 14.8 2.1 1 1 1 2 2 2 2 CCDC144C protein coiled-coil region bZIP_1 PF00170.21 EXF82416.1 - 0.0036 17.4 16.3 0.16 12.1 0.2 4.2 3 1 1 4 4 4 3 bZIP transcription factor ZapB PF06005.12 EXF82416.1 - 0.044 14.2 3.9 0.044 14.2 3.9 3.9 2 1 1 3 3 3 0 Cell division protein ZapB TSC22 PF01166.18 EXF82416.1 - 0.054 13.8 8.9 0.29 11.5 0.1 4.0 2 1 3 5 5 5 0 TSC-22/dip/bun family Spc7 PF08317.11 EXF82416.1 - 0.072 12.0 21.1 0.37 9.6 6.6 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein SurA_N PF09312.11 EXF82416.1 - 0.22 11.6 8.1 0.085 12.9 4.1 2.3 1 1 1 2 2 2 0 SurA N-terminal domain Med26 PF08711.11 EXF82416.1 - 2 8.5 5.9 1.7 8.7 0.1 3.3 3 1 0 3 3 3 0 TFIIS helical bundle-like domain Fez1 PF06818.15 EXF82416.1 - 2.1 8.8 23.0 3.6 8.0 9.6 2.4 1 1 1 2 2 2 0 Fez1 Ndc1_Nup PF09531.10 EXF82416.1 - 2.8 6.5 11.1 3.3 6.3 11.1 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup FUSC PF04632.12 EXF82416.1 - 3.9 5.9 4.9 4.4 5.7 4.9 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family YabA PF06156.13 EXF82416.1 - 4.2 8.1 19.9 11 6.7 5.3 3.4 1 1 2 3 3 3 0 Initiation control protein YabA FAM76 PF16046.5 EXF82416.1 - 4.2 6.6 18.3 5.5 6.2 18.3 1.2 1 0 0 1 1 1 0 FAM76 protein Csm1_N PF18504.1 EXF82416.1 - 5.4 7.4 19.4 4 7.8 6.8 4.1 2 2 0 3 3 3 0 Csm1 N-terminal domain IFP_35_N PF07334.13 EXF82416.1 - 8.6 6.5 16.1 4.9 7.3 2.7 3.4 2 2 1 3 3 3 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus DOT1 PF08123.13 EXF82417.1 - 7.5e-72 241.2 0.0 1.1e-71 240.6 0.0 1.2 1 0 0 1 1 1 1 Histone methylation protein DOT1 Methyltransf_25 PF13649.6 EXF82417.1 - 0.045 14.5 0.0 0.097 13.4 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_32 PF13679.6 EXF82417.1 - 0.16 12.0 0.0 0.38 10.7 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Nucleo_P87 PF07267.11 EXF82417.1 - 1.7 7.4 4.8 2.7 6.7 4.8 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 F-box PF00646.33 EXF82418.1 - 0.0012 18.7 0.0 0.0031 17.4 0.0 1.6 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EXF82418.1 - 0.024 14.5 0.0 0.066 13.1 0.0 1.7 1 0 0 1 1 1 0 F-box-like F-box-like PF12937.7 EXF82419.1 - 0.011 15.7 0.1 0.028 14.3 0.1 1.8 2 0 0 2 2 2 0 F-box-like Ceramidase PF05875.12 EXF82420.1 - 1.4e-60 204.9 6.3 1.6e-60 204.8 6.3 1.0 1 0 0 1 1 1 1 Ceramidase SID-1_RNA_chan PF13965.6 EXF82420.1 - 0.38 9.1 2.3 0.5 8.7 2.3 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Glyco_tranf_2_3 PF13641.6 EXF82421.1 - 2.4e-21 76.7 0.2 3.4e-21 76.2 0.2 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 EXF82421.1 - 3.4e-08 33.1 0.3 1.4e-07 31.1 0.3 1.9 1 1 0 1 1 1 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.26 EXF82421.1 - 1.9e-06 27.8 0.1 2.8e-06 27.3 0.1 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_5 PF13712.6 EXF82421.1 - 0.084 12.5 0.0 0.17 11.6 0.0 1.5 1 0 0 1 1 1 0 Glycosyltransferase like family Sugar_tr PF00083.24 EXF82423.1 - 3.4e-70 237.1 18.2 1.1e-54 186.0 5.2 2.0 1 1 1 2 2 2 2 Sugar (and other) transporter Phage_holin_3_2 PF04550.12 EXF82423.1 - 0.39 11.3 4.9 0.16 12.5 1.4 2.2 2 0 0 2 2 2 0 Phage holin family 2 Beta_helix PF13229.6 EXF82424.1 - 0.0035 17.2 21.5 0.15 11.9 8.6 2.3 1 1 1 2 2 2 2 Right handed beta helix region Mpv17_PMP22 PF04117.12 EXF82425.1 - 4.3e-12 46.1 7.8 4.4e-12 46.1 5.2 2.1 1 1 1 2 2 2 1 Mpv17 / PMP22 family DUF1593 PF07632.11 EXF82426.1 - 2.4e-97 325.4 0.0 3e-97 325.1 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1593) GST_C PF00043.25 EXF82427.1 - 2.1e-07 31.1 0.0 2.4e-07 30.9 0.0 1.1 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EXF82427.1 - 2.3e-05 24.5 0.0 3e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EXF82427.1 - 0.00047 20.1 0.0 0.00051 20.0 0.0 1.1 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 EXF82427.1 - 0.03 14.1 0.0 0.031 14.1 0.0 1.2 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EXF82428.1 - 9.6e-14 51.5 0.0 1.3e-13 51.1 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EXF82428.1 - 1.4e-11 44.6 0.0 1.9e-11 44.2 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EXF82428.1 - 4.1e-09 36.6 0.0 5.5e-09 36.2 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain FTO_NTD PF12933.7 EXF82428.1 - 0.015 14.5 0.0 0.015 14.5 0.0 1.1 1 0 0 1 1 1 0 FTO catalytic domain FAD_binding_4 PF01565.23 EXF82430.1 - 3.4e-23 81.9 0.3 5.8e-23 81.2 0.3 1.4 1 0 0 1 1 1 1 FAD binding domain Fungal_trans PF04082.18 EXF82431.1 - 6.2e-14 51.7 0.1 1e-13 51.0 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain DLH PF01738.18 EXF82432.1 - 9e-07 28.7 0.1 2.4e-06 27.3 0.0 1.7 2 0 0 2 2 2 1 Dienelactone hydrolase family Hydrolase_4 PF12146.8 EXF82432.1 - 5e-05 22.7 0.1 0.26 10.5 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EXF82432.1 - 0.00022 21.9 0.2 0.00029 21.5 0.2 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EXF82432.1 - 0.00026 20.7 0.0 0.0008 19.1 0.0 1.7 2 0 0 2 2 2 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EXF82432.1 - 0.003 17.1 0.0 0.044 13.2 0.0 2.2 2 0 0 2 2 2 1 Prolyl oligopeptidase family AXE1 PF05448.12 EXF82432.1 - 0.0097 14.6 0.0 0.02 13.6 0.0 1.4 1 0 0 1 1 1 1 Acetyl xylan esterase (AXE1) Ectoine_synth PF06339.12 EXF82433.1 - 0.0065 16.7 0.1 0.0085 16.3 0.1 1.1 1 0 0 1 1 1 1 Ectoine synthase p450 PF00067.22 EXF82434.1 - 2e-32 112.6 0.0 2.6e-32 112.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 EXF82435.1 - 8.8e-61 206.0 0.0 1.1e-60 205.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Glyoxalase PF00903.25 EXF82436.1 - 2.7e-05 24.4 1.8 0.00028 21.1 1.1 2.6 3 0 0 3 3 3 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily FAA_hydrolase PF01557.18 EXF82437.1 - 1.9e-53 181.4 0.0 2.2e-53 181.2 0.0 1.0 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family Tnp_P_element_C PF12596.8 EXF82437.1 - 0.056 14.0 0.1 0.09 13.3 0.1 1.3 1 0 0 1 1 1 0 87kDa Transposase Beta-lactamase PF00144.24 EXF82438.1 - 1.2e-38 133.2 0.9 1.7e-38 132.7 0.9 1.1 1 0 0 1 1 1 1 Beta-lactamase Beta-lactamase2 PF13354.6 EXF82438.1 - 0.14 11.8 0.0 0.79 9.3 0.0 1.9 2 0 0 2 2 2 0 Beta-lactamase enzyme family Zn_clus PF00172.18 EXF82439.1 - 2.5e-08 33.9 11.3 2.5e-08 33.9 11.3 1.7 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EXF82439.1 - 4e-08 32.6 0.1 1.1e-07 31.2 0.1 1.8 1 0 0 1 1 1 1 Fungal specific transcription factor domain AA_permease_2 PF13520.6 EXF82440.1 - 1.3e-40 139.6 42.3 1.6e-40 139.2 42.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EXF82440.1 - 9.9e-21 73.9 38.8 1.5e-20 73.2 38.8 1.2 1 0 0 1 1 1 1 Amino acid permease Deltameth_res PF16020.5 EXF82440.1 - 0.34 10.8 3.4 1.6 8.6 1.2 2.9 2 0 0 2 2 2 0 Deltamethrin resistance FAD_binding_3 PF01494.19 EXF82441.1 - 1.4e-21 77.2 2.6 8.6e-20 71.3 2.5 2.8 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EXF82441.1 - 1.9e-10 40.5 0.2 2.9e-05 23.5 0.1 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EXF82441.1 - 4e-07 29.1 0.1 0.002 16.9 0.1 2.1 2 0 0 2 2 2 2 HI0933-like protein FAD_binding_2 PF00890.24 EXF82441.1 - 8.6e-07 28.4 0.1 1.4e-06 27.7 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 EXF82441.1 - 2.3e-05 24.1 1.4 0.00051 19.7 0.5 2.4 1 1 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 EXF82441.1 - 6.7e-05 23.4 1.7 0.018 15.6 0.8 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EXF82441.1 - 0.00012 22.2 0.1 0.00031 20.9 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 EXF82441.1 - 0.00023 20.6 0.3 0.00059 19.3 0.2 1.7 2 0 0 2 2 2 1 FAD dependent oxidoreductase GIDA PF01134.22 EXF82441.1 - 0.00044 19.5 0.1 0.0011 18.2 0.1 1.6 2 0 0 2 2 2 1 Glucose inhibited division protein A Thi4 PF01946.17 EXF82441.1 - 0.0044 16.3 0.1 0.0073 15.6 0.1 1.3 1 0 0 1 1 1 1 Thi4 family Lycopene_cycl PF05834.12 EXF82441.1 - 0.01 14.9 0.4 2.5 7.0 0.1 2.7 3 0 0 3 3 3 0 Lycopene cyclase protein Pyr_redox_3 PF13738.6 EXF82441.1 - 0.027 13.7 0.1 0.14 11.4 0.1 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EXF82441.1 - 0.14 10.9 1.3 1.1 8.0 0.0 2.1 2 0 0 2 2 2 0 Tryptophan halogenase Cys_Met_Meta_PP PF01053.20 EXF82442.1 - 5e-121 403.8 0.0 5.7e-121 403.6 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 EXF82442.1 - 1.4e-10 41.0 0.2 3.1e-10 39.9 0.1 1.6 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 EXF82442.1 - 2.9e-06 26.5 0.1 4.9e-06 25.7 0.1 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 EXF82442.1 - 5.5e-06 25.9 0.0 1.5e-05 24.5 0.0 1.4 1 1 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.21 EXF82442.1 - 0.012 14.8 0.0 0.018 14.2 0.0 1.3 1 0 0 1 1 1 0 Aminotransferase class I and II SepSecS PF05889.13 EXF82442.1 - 0.17 10.5 0.0 0.26 9.9 0.0 1.2 1 0 0 1 1 1 0 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS adh_short_C2 PF13561.6 EXF82443.1 - 3.6e-46 157.6 0.0 8.8e-45 153.1 0.0 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF82443.1 - 1e-38 132.8 0.0 1.6e-38 132.1 0.0 1.3 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EXF82443.1 - 9.7e-08 32.1 0.0 0.0014 18.6 0.0 2.2 2 0 0 2 2 2 2 KR domain THF_DHG_CYH_C PF02882.19 EXF82443.1 - 0.011 15.1 0.0 0.44 9.9 0.0 2.4 2 0 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain DAO PF01266.24 EXF82444.1 - 2.6e-34 119.4 0.0 4.2e-32 112.1 0.0 2.3 2 0 0 2 2 2 1 FAD dependent oxidoreductase Amino_oxidase PF01593.24 EXF82444.1 - 7.2e-26 91.5 0.5 1.8e-25 90.1 0.1 1.9 2 1 0 2 2 2 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EXF82444.1 - 4.7e-12 46.0 0.3 2.8e-05 24.2 0.1 2.7 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EXF82444.1 - 2.7e-07 30.1 0.1 0.0028 17.0 0.0 3.4 4 0 0 4 4 4 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EXF82444.1 - 3.4e-05 23.3 0.0 0.07 12.4 0.0 2.3 2 0 0 2 2 2 2 FAD binding domain Pyr_redox PF00070.27 EXF82444.1 - 0.00014 22.3 0.1 0.012 16.2 0.0 2.8 3 0 0 3 3 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EXF82444.1 - 0.014 15.4 0.3 0.34 10.9 0.0 2.8 3 0 0 3 3 3 0 FAD-NAD(P)-binding Pyr_redox_3 PF13738.6 EXF82444.1 - 0.02 14.2 0.2 3.4 6.8 0.0 2.9 3 1 1 4 4 4 0 Pyridine nucleotide-disulphide oxidoreductase 2-Hacid_dh_C PF02826.19 EXF82444.1 - 0.026 13.9 0.0 0.071 12.5 0.0 1.7 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ARL2_Bind_BART PF11527.8 EXF82444.1 - 0.027 14.5 0.0 0.069 13.3 0.0 1.6 1 0 0 1 1 1 0 The ARF-like 2 binding protein BART 3HCDH_N PF02737.18 EXF82444.1 - 0.046 13.6 0.0 0.085 12.7 0.0 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Glu_dehyd_C PF16912.5 EXF82444.1 - 0.049 13.1 0.0 0.11 11.9 0.0 1.5 1 0 0 1 1 1 0 Glucose dehydrogenase C-terminus ApbA PF02558.16 EXF82444.1 - 0.1 12.3 0.1 0.58 9.8 0.0 2.2 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA NAD_binding_2 PF03446.15 EXF82444.1 - 0.11 12.6 0.1 0.3 11.2 0.0 1.7 2 0 0 2 2 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Thi4 PF01946.17 EXF82444.1 - 0.12 11.6 0.3 1.2 8.3 0.0 2.1 2 0 0 2 2 2 0 Thi4 family FAD_binding_2 PF00890.24 EXF82444.1 - 0.15 11.1 0.1 0.66 9.0 0.0 2.0 2 0 0 2 2 2 0 FAD binding domain NAD_Gly3P_dh_N PF01210.23 EXF82444.1 - 0.21 11.5 0.0 0.67 9.9 0.0 1.8 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus MFS_1 PF07690.16 EXF82445.1 - 3.4e-23 82.1 23.9 7.9e-23 80.9 22.0 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Tannase PF07519.11 EXF82446.1 - 1.6e-88 297.7 0.0 1.2e-87 294.8 0.0 1.9 1 1 0 1 1 1 1 Tannase and feruloyl esterase Abhydrolase_1 PF00561.20 EXF82446.1 - 0.0066 16.1 0.0 0.012 15.3 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold COG2 PF06148.11 EXF82447.1 - 8.7e-25 87.3 0.0 1.3e-24 86.8 0.0 1.2 1 0 0 1 1 1 1 COG (conserved oligomeric Golgi) complex component, COG2 Vps51 PF08700.11 EXF82447.1 - 0.0069 16.4 0.0 0.019 15.0 0.0 1.8 2 0 0 2 2 2 1 Vps51/Vps67 Spc7 PF08317.11 EXF82447.1 - 0.18 10.7 0.0 0.26 10.1 0.0 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein RNA_pol_3_Rpc31 PF11705.8 EXF82447.1 - 0.21 11.8 7.4 0.29 11.4 7.4 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 CENP-B_dimeris PF09026.10 EXF82447.1 - 0.44 11.0 7.4 0.93 9.9 7.4 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain NOA36 PF06524.12 EXF82447.1 - 2.2 7.5 3.9 3.1 7.0 3.9 1.1 1 0 0 1 1 1 0 NOA36 protein Ribosomal_60s PF00428.19 EXF82447.1 - 3.2 8.4 6.7 7.6 7.2 6.7 1.6 1 0 0 1 1 1 0 60s Acidic ribosomal protein DNA_pol_phi PF04931.13 EXF82447.1 - 4.7 5.2 6.8 6.4 4.7 6.8 1.1 1 0 0 1 1 1 0 DNA polymerase phi Ribosomal_L1 PF00687.21 EXF82448.1 - 1.4e-21 77.2 0.1 2e-21 76.7 0.1 1.3 1 1 0 1 1 1 1 Ribosomal protein L1p/L10e family Salt_tol_Pase PF09506.10 EXF82448.1 - 0.034 12.9 0.0 0.053 12.3 0.0 1.2 1 0 0 1 1 1 0 Glucosylglycerol-phosphate phosphatase (Salt_tol_Pase) tRNA-synt_1c PF00749.21 EXF82449.1 - 6.5e-104 347.2 0.1 9.8e-104 346.6 0.1 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 EXF82449.1 - 1.8e-39 135.4 0.0 3.7e-39 134.4 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain tRNA-synt_1e PF01406.19 EXF82449.1 - 0.011 15.1 0.2 0.026 13.9 0.2 1.5 1 1 0 1 1 1 0 tRNA synthetases class I (C) catalytic domain Glyco_hydro_4C PF11975.8 EXF82449.1 - 0.11 12.5 0.1 0.21 11.7 0.1 1.4 1 0 0 1 1 1 0 Family 4 glycosyl hydrolase C-terminal domain 2-Hacid_dh_C PF02826.19 EXF82450.1 - 3.7e-36 124.1 0.0 5.5e-36 123.6 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_2 PF03446.15 EXF82450.1 - 4.4e-06 26.9 0.0 7.2e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh PF00389.30 EXF82450.1 - 0.0031 17.2 0.0 0.0069 16.1 0.0 1.5 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain HET PF06985.11 EXF82451.1 - 9.2e-05 22.8 0.0 0.00015 22.1 0.0 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) DUF2207 PF09972.9 EXF82452.1 - 0.42 9.3 0.0 0.42 9.3 0.0 3.1 1 1 0 2 2 2 0 Predicted membrane protein (DUF2207) Sugar_tr PF00083.24 EXF82453.1 - 1.6e-108 363.5 27.4 1.8e-108 363.3 27.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF82453.1 - 3.8e-24 85.3 45.6 8.4e-20 71.0 9.5 2.1 1 1 0 2 2 2 2 Major Facilitator Superfamily Cyclase PF04199.13 EXF82454.1 - 4.3e-18 65.9 0.0 5.4e-18 65.5 0.0 1.2 1 0 0 1 1 1 1 Putative cyclase Fungal_trans PF04082.18 EXF82455.1 - 5.9e-22 78.0 0.0 8.4e-22 77.5 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF82455.1 - 1.2e-07 31.8 9.4 1.2e-07 31.8 9.4 1.6 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DMPK_coil PF08826.10 EXF82455.1 - 0.066 13.3 0.2 0.59 10.3 0.0 2.5 3 0 0 3 3 3 0 DMPK coiled coil domain like MFS_1 PF07690.16 EXF82456.1 - 5.4e-29 101.2 38.4 5.4e-29 101.2 38.4 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily TMEM51 PF15345.6 EXF82456.1 - 0.51 10.1 3.7 0.75 9.6 0.0 2.1 2 0 0 2 2 2 0 Transmembrane protein 51 CoA_transf_3 PF02515.17 EXF82457.1 - 5.8e-50 170.4 0.0 1.9e-48 165.5 0.0 2.2 2 0 0 2 2 2 1 CoA-transferase family III DUF4387 PF14330.6 EXF82457.1 - 4.8e-40 136.2 0.0 1e-39 135.1 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4387) AtuA PF07287.11 EXF82457.1 - 7e-20 71.0 0.0 4.3e-19 68.5 0.0 2.0 1 1 0 1 1 1 1 Acyclic terpene utilisation family protein AtuA dbPDZ_assoc PF16610.5 EXF82457.1 - 0.066 13.4 1.3 0.15 12.3 0.5 2.0 2 0 0 2 2 2 0 Unstructured region between two PDZ domains on Dlg5 HAT_KAT11 PF08214.11 EXF82458.1 - 3e-97 326.1 0.0 4.5e-97 325.5 0.0 1.3 1 1 0 1 1 1 1 Histone acetylation protein Nucleo_P87 PF07267.11 EXF82458.1 - 1.8 7.3 3.3 2.6 6.8 3.3 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Ribonucleas_3_3 PF14622.6 EXF82459.1 - 3e-27 95.3 0.0 7e-27 94.1 0.0 1.6 1 1 0 1 1 1 1 Ribonuclease-III-like Ribonuclease_3 PF00636.26 EXF82459.1 - 0.018 15.7 0.0 0.053 14.1 0.0 1.9 2 1 0 2 2 2 0 Ribonuclease III domain Peptidase_M22 PF00814.25 EXF82461.1 - 0.028 14.1 0.2 0.064 13.0 0.2 1.6 1 0 0 1 1 1 0 Glycoprotease family TMEM100 PF16311.5 EXF82461.1 - 2.6 7.7 7.7 0.24 11.0 2.4 1.9 2 0 0 2 2 2 0 Transmembrane protein 100 K_channel_TID PF07941.11 EXF82462.1 - 7.6e-05 23.1 5.6 0.00028 21.3 5.6 1.9 1 0 0 1 1 1 1 Potassium channel Kv1.4 tandem inactivation domain Sporozoite_P67 PF05642.11 EXF82462.1 - 9 4.2 16.1 17 3.4 16.1 1.4 1 0 0 1 1 1 0 Sporozoite P67 surface antigen WSC PF01822.19 EXF82463.1 - 1.9e-12 47.2 4.3 1.9e-12 47.2 4.3 3.5 3 1 1 4 4 4 1 WSC domain TauD PF02668.16 EXF82464.1 - 1.4e-40 139.8 0.2 2e-40 139.3 0.2 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family MFS_1 PF07690.16 EXF82465.1 - 9.2e-14 51.1 27.6 9.2e-14 51.1 27.6 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily UNC-93 PF05978.16 EXF82465.1 - 7e-11 42.1 4.8 7e-11 42.1 4.8 2.0 2 0 0 2 2 2 1 Ion channel regulatory protein UNC-93 Sugar_tr PF00083.24 EXF82465.1 - 1.9e-06 27.0 3.7 1.9e-06 27.0 3.7 1.6 2 0 0 2 2 2 1 Sugar (and other) transporter Hydrophobin_2 PF06766.11 EXF82466.1 - 3.8e-26 90.8 10.7 4.8e-26 90.5 10.7 1.1 1 0 0 1 1 1 1 Fungal hydrophobin Tryp_inh PF17983.1 EXF82466.1 - 8.2 6.6 11.4 1.4 9.0 2.3 2.8 3 0 0 3 3 3 0 Trypsin inhibitors 1,2 and 3 p450 PF00067.22 EXF82468.1 - 4e-67 227.0 0.0 5.3e-67 226.5 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Fungal_trans_2 PF11951.8 EXF82469.1 - 2e-08 33.4 0.1 3.4e-08 32.7 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Sugar_tr PF00083.24 EXF82470.1 - 8.2e-103 344.7 28.0 9.6e-103 344.4 28.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF82470.1 - 1.4e-31 109.7 29.5 1.4e-31 109.7 29.5 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF3007 PF11460.8 EXF82470.1 - 0.1 12.9 0.1 0.49 10.7 0.1 2.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3007) Rrp15p PF07890.12 EXF82471.1 - 3.6e-40 137.4 14.1 3.6e-40 137.4 14.1 2.4 2 1 0 2 2 2 1 Rrp15p Herpes_DNAp_acc PF04929.12 EXF82471.1 - 4.9 6.0 11.2 7.7 5.4 11.2 1.4 1 0 0 1 1 1 0 Herpes DNA replication accessory factor Fer2 PF00111.27 EXF82472.1 - 3.3e-14 52.6 1.0 5e-14 52.0 1.0 1.3 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Acyl-CoA_dh_2 PF08028.11 EXF82472.1 - 0.055 13.7 0.2 0.091 13.0 0.2 1.3 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase, C-terminal domain Mito_carr PF00153.27 EXF82473.1 - 4.5e-15 55.3 7.0 3.1e-05 23.8 0.2 4.9 3 2 0 3 3 3 3 Mitochondrial carrier protein DUF908 PF06012.12 EXF82473.1 - 0.037 13.5 0.4 0.057 12.8 0.4 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) Glyco_hydro_61 PF03443.14 EXF82474.1 - 1.4e-64 217.8 0.1 1.4e-64 217.8 0.1 1.7 2 0 0 2 2 2 1 Glycosyl hydrolase family 61 CBM_1 PF00734.18 EXF82474.1 - 1.7e-21 75.8 20.1 9.2e-11 41.5 5.6 2.8 2 0 0 2 2 2 2 Fungal cellulose binding domain Velvet PF11754.8 EXF82474.1 - 0.061 13.3 8.4 0.11 12.4 8.4 1.4 1 0 0 1 1 1 0 Velvet factor CSD PF00313.22 EXF82474.1 - 0.088 12.7 0.0 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 'Cold-shock' DNA-binding domain Pex14_N PF04695.13 EXF82474.1 - 1.1 9.9 10.1 2 9.0 10.1 1.4 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region SOG2 PF10428.9 EXF82474.1 - 7.2 5.7 29.2 10 5.2 29.2 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein KAR9 PF08580.10 EXF82474.1 - 8 4.9 16.4 11 4.4 16.4 1.0 1 0 0 1 1 1 0 Yeast cortical protein KAR9 Fungal_trans_2 PF11951.8 EXF82476.1 - 6.8e-19 67.9 0.1 9.2e-19 67.5 0.1 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF82476.1 - 0.00038 20.5 8.5 0.0011 19.0 8.5 1.8 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pro_racemase PF05544.11 EXF82477.1 - 5.3e-126 420.1 0.0 6.1e-126 419.9 0.0 1.0 1 0 0 1 1 1 1 Proline racemase MFS_1 PF07690.16 EXF82478.1 - 2e-25 89.5 33.2 4.9e-25 88.2 25.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF82478.1 - 5.2e-11 42.1 23.1 1.8e-06 27.1 2.4 3.0 2 1 1 3 3 3 3 Sugar (and other) transporter TRI12 PF06609.13 EXF82478.1 - 5.3e-09 35.1 5.0 8.7e-09 34.3 5.0 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Helicase_C PF00271.31 EXF82479.1 - 1.7e-18 67.0 0.0 4.3e-16 59.2 0.0 3.1 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DEAD PF00270.29 EXF82479.1 - 7.1e-18 65.0 0.3 3e-17 62.9 0.0 2.2 3 0 0 3 3 3 1 DEAD/DEAH box helicase RecQ_Zn_bind PF16124.5 EXF82479.1 - 1.3e-05 25.8 0.3 3.6e-05 24.4 0.3 1.8 1 0 0 1 1 1 1 RecQ zinc-binding F-box-like PF12937.7 EXF82480.1 - 3e-06 27.0 0.2 1.3e-05 25.0 0.2 2.1 1 1 0 1 1 1 1 F-box-like F-box PF00646.33 EXF82480.1 - 4.7e-05 23.2 0.2 0.0011 18.8 0.2 2.8 1 1 0 1 1 1 1 F-box domain CSG2 PF16965.5 EXF82481.1 - 0.61 9.0 1.6 1.3 7.8 1.6 1.7 1 1 0 1 1 1 0 Ceramide synthase regulator GET2 PF08690.10 EXF82481.1 - 7.4 6.2 14.7 10 5.7 14.7 1.3 1 0 0 1 1 1 0 GET complex subunit GET2 Glyco_hydro_43 PF04616.14 EXF82482.1 - 5.9e-58 196.5 1.3 7.5e-58 196.1 1.3 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 GH43_C2 PF17851.1 EXF82482.1 - 3.1e-09 36.8 0.0 5e-09 36.2 0.0 1.3 1 0 0 1 1 1 1 Beta xylosidase C-terminal Concanavalin A-like domain Oxidored_q6 PF01058.22 EXF82484.1 - 1.7e-22 79.6 0.2 2.4e-22 79.2 0.2 1.2 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase, 20 Kd subunit DEC-1_C PF04626.13 EXF82484.1 - 0.12 12.7 0.3 0.2 12.1 0.3 1.3 1 0 0 1 1 1 0 Dec-1 protein, C terminal region Zn_clus PF00172.18 EXF82485.1 - 5.5e-05 23.2 8.1 5.5e-05 23.2 8.1 2.3 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EXF82485.1 - 0.00056 19.0 0.0 0.0023 17.0 0.0 1.9 1 1 0 1 1 1 1 Fungal specific transcription factor domain Dioxygenase_C PF00775.21 EXF82486.1 - 3.2e-07 30.0 0.0 5.5e-07 29.2 0.0 1.3 1 0 0 1 1 1 1 Dioxygenase AAA_16 PF13191.6 EXF82487.1 - 1.4e-07 32.1 0.8 4.6e-07 30.4 0.2 2.2 2 1 0 2 2 2 1 AAA ATPase domain ATPase_2 PF01637.18 EXF82487.1 - 0.00037 20.5 0.0 0.00068 19.6 0.0 1.4 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea DUF815 PF05673.13 EXF82487.1 - 0.0012 18.1 0.0 0.0027 16.9 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_25 PF13481.6 EXF82487.1 - 0.025 14.2 0.0 0.067 12.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EXF82487.1 - 0.033 13.9 0.1 0.077 12.7 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain ATPase PF06745.13 EXF82487.1 - 0.055 12.8 0.4 0.13 11.6 0.0 1.7 2 0 0 2 2 2 0 KaiC HisKA PF00512.25 EXF82487.1 - 0.076 13.1 0.0 0.22 11.6 0.0 1.7 1 0 0 1 1 1 0 His Kinase A (phospho-acceptor) domain AAA_22 PF13401.6 EXF82487.1 - 0.091 13.0 0.3 0.29 11.4 0.3 1.8 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EXF82487.1 - 0.1 12.1 0.0 0.19 11.2 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region NTPase_1 PF03266.15 EXF82487.1 - 0.16 11.9 0.0 0.37 10.7 0.0 1.6 1 0 0 1 1 1 0 NTPase IPP-2 PF04979.14 EXF82488.1 - 1.2e-24 87.5 12.2 1.2e-24 87.5 12.2 2.0 2 0 0 2 2 2 1 Protein phosphatase inhibitor 2 (IPP-2) DUF2076 PF09849.9 EXF82489.1 - 0.0013 18.8 0.4 0.0013 18.8 0.4 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2076) Ribosomal_L27 PF01016.19 EXF82490.1 - 1.2e-25 89.4 0.3 2.7e-25 88.2 0.0 1.8 2 0 0 2 2 2 1 Ribosomal L27 protein DUF3716 PF12511.8 EXF82491.1 - 5.7e-07 29.5 3.2 1.1e-06 28.6 3.2 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3716) Transp_cyt_pur PF02133.15 EXF82492.1 - 4.1e-100 335.6 40.4 5e-100 335.3 40.4 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin DIOX_N PF14226.6 EXF82493.1 - 3.5e-26 92.3 0.2 5.8e-26 91.6 0.2 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EXF82493.1 - 4.4e-24 84.9 0.0 1.1e-23 83.6 0.0 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily HET PF06985.11 EXF82494.1 - 1.3e-17 64.6 0.0 2.9e-17 63.4 0.0 1.7 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) DUF3176 PF11374.8 EXF82495.1 - 1.1e-33 115.7 5.1 1.3e-33 115.4 1.8 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF3176) SET PF00856.28 EXF82497.1 - 4.2e-21 76.1 0.0 7.9e-21 75.2 0.0 1.5 1 0 0 1 1 1 1 SET domain Rubis-subs-bind PF09273.11 EXF82497.1 - 3.9e-12 47.0 1.0 8.9e-12 45.8 1.0 1.7 1 0 0 1 1 1 1 Rubisco LSMT substrate-binding GHMP_kinases_N PF00288.26 EXF82498.1 - 0.13 12.5 0.0 0.25 11.6 0.0 1.4 1 0 0 1 1 1 0 GHMP kinases N terminal domain Adap_comp_sub PF00928.21 EXF82499.1 - 1.1e-90 303.6 0.0 1.9e-90 302.8 0.0 1.4 2 0 0 2 2 2 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 EXF82499.1 - 6.9e-09 35.8 0.2 1.1e-08 35.1 0.2 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Opi1 PF08618.10 EXF82500.1 - 4.4e-36 125.0 9.1 1.3e-29 103.8 1.7 4.8 4 1 1 5 5 5 3 Transcription factor Opi1 AA_permease_N PF08403.10 EXF82500.1 - 0.014 14.9 0.3 0.035 13.6 0.3 1.6 1 0 0 1 1 1 0 Amino acid permease N-terminal Glyco_hydro_71 PF03659.14 EXF82501.1 - 2e-119 398.8 1.4 2.3e-119 398.6 1.4 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 71 Amidohydro_2 PF04909.14 EXF82501.1 - 0.094 12.5 0.0 0.18 11.6 0.0 1.4 1 0 0 1 1 1 0 Amidohydrolase AP_endonuc_2 PF01261.24 EXF82501.1 - 0.13 11.7 0.0 0.23 10.9 0.0 1.4 1 0 0 1 1 1 0 Xylose isomerase-like TIM barrel M-factor PF03855.13 EXF82501.1 - 0.7 10.1 2.7 2.8 8.1 0.3 2.8 3 0 0 3 3 3 0 M-factor Glyco_hydro_71 PF03659.14 EXF82502.1 - 2e-127 425.1 1.8 2.4e-127 424.9 1.8 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 71 DUF4434 PF14488.6 EXF82502.1 - 0.16 12.0 0.0 0.28 11.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4434) GMC_oxred_N PF00732.19 EXF82504.1 - 6.5e-60 203.0 0.0 8.9e-60 202.6 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EXF82504.1 - 2.5e-27 96.2 0.0 4.3e-27 95.4 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase Lycopene_cycl PF05834.12 EXF82504.1 - 0.00011 21.4 0.0 0.00016 20.8 0.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein FAD_binding_2 PF00890.24 EXF82504.1 - 0.00027 20.2 2.5 0.0019 17.4 2.5 2.0 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.24 EXF82504.1 - 0.0032 17.1 3.0 0.0053 16.4 3.0 1.4 1 1 0 1 1 1 1 FAD dependent oxidoreductase Trp_halogenase PF04820.14 EXF82504.1 - 0.0054 15.6 0.1 0.0088 14.9 0.1 1.3 1 0 0 1 1 1 1 Tryptophan halogenase Thi4 PF01946.17 EXF82504.1 - 0.0069 15.7 0.1 0.0069 15.7 0.1 1.6 2 0 0 2 2 2 1 Thi4 family NAD_binding_8 PF13450.6 EXF82504.1 - 0.095 12.9 0.4 0.51 10.6 0.1 2.3 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EXF82504.1 - 0.15 11.3 0.0 0.41 9.8 0.0 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Glyco_hydro_2_C PF02836.17 EXF82505.1 - 1.9e-104 349.1 0.0 2.5e-104 348.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Bgal_small_N PF02929.17 EXF82505.1 - 5.6e-69 232.4 0.0 1.1e-68 231.5 0.0 1.5 1 0 0 1 1 1 1 Beta galactosidase small chain Glyco_hydro_2_N PF02837.18 EXF82505.1 - 1.1e-47 162.1 0.2 2.7e-47 160.8 0.2 1.7 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain DUF4981 PF16353.5 EXF82505.1 - 4.2e-21 75.2 0.4 1.5e-19 70.3 0.1 2.8 2 0 0 2 2 2 1 Domain of unknown function(DUF4981) Glyco_hydro_2 PF00703.21 EXF82505.1 - 4.3e-16 59.6 0.6 1.3e-15 58.0 0.3 2.0 2 0 0 2 2 2 1 Glycosyl hydrolases family 2 BetaGal_dom4_5 PF13364.6 EXF82505.1 - 0.00012 22.6 0.1 0.00063 20.3 0.1 2.2 2 0 0 2 2 2 1 Beta-galactosidase jelly roll domain Sugar_tr PF00083.24 EXF82506.1 - 1e-95 321.2 23.3 1.5e-95 320.8 23.3 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF82506.1 - 2.4e-30 105.7 23.4 3.8e-30 105.0 22.2 2.0 2 0 0 2 2 2 1 Major Facilitator Superfamily Fungal_trans PF04082.18 EXF82506.1 - 2.1e-05 23.7 0.6 0.00012 21.2 0.6 2.3 1 1 0 1 1 1 1 Fungal specific transcription factor domain Arylesterase PF01731.20 EXF82507.1 - 0.024 14.8 0.0 0.085 13.1 0.0 2.1 1 0 0 1 1 1 0 Arylesterase Rdx PF10262.9 EXF82508.1 - 0.03 14.5 0.1 0.13 12.5 0.0 2.0 2 0 0 2 2 2 0 Rdx family RIFIN PF02009.16 EXF82508.1 - 1.2 9.0 9.5 0.13 12.2 5.2 1.5 2 0 0 2 2 2 0 Rifin E1-E2_ATPase PF00122.20 EXF82509.1 - 4.1e-37 127.5 13.9 9.3e-31 106.7 0.1 3.2 3 0 0 3 3 3 2 E1-E2 ATPase Cation_ATPase_C PF00689.21 EXF82509.1 - 7.5e-24 84.4 12.1 7.5e-24 84.4 12.1 2.4 2 1 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 EXF82509.1 - 3.8e-20 73.1 0.0 1.9e-18 67.5 0.0 2.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EXF82509.1 - 1.4e-15 57.1 0.0 3.1e-15 56.0 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 EXF82509.1 - 1e-13 50.7 0.0 2.5e-13 49.5 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EXF82509.1 - 0.0004 20.2 0.3 0.0009 19.0 0.2 1.7 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DctM PF06808.12 EXF82509.1 - 0.01 14.7 5.2 0.56 9.0 0.0 2.8 3 0 0 3 3 3 0 Tripartite ATP-independent periplasmic transporter, DctM component UvdE PF03851.14 EXF82511.1 - 1.7e-113 378.5 0.0 2.2e-113 378.1 0.0 1.2 1 0 0 1 1 1 1 UV-endonuclease UvdE 2_5_RNA_ligase2 PF13563.6 EXF82511.1 - 0.015 15.2 0.1 0.036 14.0 0.1 1.6 1 0 0 1 1 1 0 2'-5' RNA ligase superfamily DUF5323 PF17257.2 EXF82511.1 - 0.35 10.8 18.8 1.3 9.0 3.6 3.6 3 0 0 3 3 3 0 Family of unknown function (DUF5323) ORC_WH_C PF18137.1 EXF82511.1 - 5.3 7.1 6.6 0.93 9.6 2.5 1.8 2 0 0 2 2 2 0 Origin recognition complex winged helix C-terminal Aa_trans PF01490.18 EXF82512.1 - 1.6e-31 109.4 26.6 3.7e-31 108.3 26.6 1.4 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein TAFII28 PF04719.14 EXF82513.1 - 3.5e-32 110.3 0.0 5.9e-32 109.6 0.0 1.4 1 0 0 1 1 1 1 hTAFII28-like protein conserved region GTP_cyclohydroI PF01227.22 EXF82514.1 - 7.2e-75 250.3 0.6 9.7e-75 249.9 0.6 1.2 1 0 0 1 1 1 1 GTP cyclohydrolase I QueF PF14489.6 EXF82514.1 - 0.0022 18.1 0.0 0.0041 17.2 0.0 1.4 1 0 0 1 1 1 1 QueF-like protein Apt1 PF10351.9 EXF82514.1 - 0.48 9.2 6.9 0.61 8.9 6.9 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain Ssu72 PF04722.13 EXF82515.1 - 2e-84 281.9 0.0 2.3e-84 281.7 0.0 1.0 1 0 0 1 1 1 1 Ssu72-like protein GIT_SHD PF08518.11 EXF82516.1 - 7.6e-23 79.8 5.7 2.4e-11 43.0 2.4 2.6 2 0 0 2 2 2 2 Spa2 homology domain (SHD) of GIT CLZ PF16526.5 EXF82516.1 - 0.013 15.9 1.6 0.013 15.9 1.6 4.0 2 1 0 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels FUSC PF04632.12 EXF82516.1 - 0.059 11.9 16.6 0.0092 14.6 12.2 1.8 2 0 0 2 2 2 0 Fusaric acid resistance protein family PSII_Pbs27 PF13326.6 EXF82516.1 - 0.087 13.1 7.2 0.18 12.1 1.1 2.8 2 0 0 2 2 2 0 Photosystem II Pbs27 HetR_C PF18460.1 EXF82516.1 - 0.25 11.3 3.6 4.3 7.3 0.2 2.9 2 0 0 2 2 2 0 Heterocyst differentiation regulator C-terminal Hood domain DUF1843 PF08898.10 EXF82516.1 - 0.3 11.6 2.9 0.58 10.7 0.3 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1843) UPF0242 PF06785.11 EXF82516.1 - 0.31 11.1 38.1 2.9 8.0 17.1 2.7 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus PLAC9 PF15205.6 EXF82516.1 - 0.34 11.3 1.8 10 6.6 0.1 3.1 3 0 0 3 3 3 0 Placenta-specific protein 9 OmpH PF03938.14 EXF82516.1 - 0.86 9.9 44.5 5.6 7.3 0.0 4.7 3 1 3 6 6 6 0 Outer membrane protein (OmpH-like) THP2 PF09432.10 EXF82516.1 - 3 7.9 12.0 0.19 11.8 4.2 2.6 1 1 2 3 3 3 0 Tho complex subunit THP2 DUF4407 PF14362.6 EXF82516.1 - 4.6 6.5 41.0 0.84 8.9 16.6 4.0 2 1 1 4 4 4 0 Domain of unknown function (DUF4407) DUF592 PF04574.13 EXF82517.1 - 0.061 13.1 0.0 0.096 12.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF592) DUF2070 PF09843.9 EXF82518.1 - 2.2 6.5 5.5 2.7 6.2 5.5 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Sec62 PF03839.16 EXF82518.1 - 6.7 6.2 6.5 8.8 5.8 6.5 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 GFA PF04828.14 EXF82519.1 - 1.1e-06 28.8 0.2 1.8e-06 28.2 0.2 1.4 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme zf-C3HC4_5 PF17121.5 EXF82519.1 - 0.033 14.1 1.7 0.054 13.4 1.7 1.2 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) MTHFR_C PF12225.8 EXF82519.1 - 0.064 12.9 0.6 0.11 12.2 0.2 1.7 2 0 0 2 2 2 0 Methylene-tetrahydrofolate reductase C terminal DUF1295 PF06966.12 EXF82520.1 - 6.5e-58 196.0 0.3 8.4e-58 195.7 0.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) Steroid_dh PF02544.16 EXF82520.1 - 5e-07 29.8 5.0 5.7e-07 29.6 0.0 3.0 1 1 2 4 4 4 1 3-oxo-5-alpha-steroid 4-dehydrogenase ICMT PF04140.14 EXF82520.1 - 0.0001 22.6 0.8 0.00044 20.6 0.0 2.3 2 1 0 2 2 2 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 EXF82520.1 - 0.00034 21.0 0.1 0.0041 17.5 0.1 2.7 1 1 0 1 1 1 1 Phospholipid methyltransferase DUF1056 PF06341.11 EXF82520.1 - 0.93 9.8 0.1 0.93 9.8 0.1 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1056) RNase_P_p30 PF01876.16 EXF82522.1 - 2.3e-55 187.4 0.0 3.3e-55 186.9 0.0 1.2 1 0 0 1 1 1 1 RNase P subunit p30 zinc_ribbon_15 PF17032.5 EXF82523.1 - 0.00015 22.5 0.6 0.00021 22.0 0.6 1.2 1 0 0 1 1 1 1 zinc-ribbon family DUF4547 PF15080.6 EXF82524.1 - 0.015 14.9 0.1 0.02 14.5 0.1 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4547) Yip1 PF04893.17 EXF82524.1 - 0.048 13.4 0.0 0.076 12.7 0.0 1.4 1 0 0 1 1 1 0 Yip1 domain DUF155 PF02582.14 EXF82525.1 - 1.2e-55 188.4 0.4 2e-55 187.6 0.1 1.5 2 0 0 2 2 2 1 Uncharacterised ACR, YagE family COG1723 ECSCR PF15820.5 EXF82525.1 - 0.1 12.4 0.6 0.25 11.2 0.2 1.8 2 0 0 2 2 2 0 Endothelial cell-specific chemotaxis regulator Insulin_TMD PF17870.1 EXF82525.1 - 0.14 12.2 0.6 0.25 11.4 0.6 1.4 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment E1-E2_ATPase PF00122.20 EXF82526.1 - 4.2e-51 173.0 0.1 1.4e-50 171.3 0.1 1.9 1 0 0 1 1 1 1 E1-E2 ATPase HMA PF00403.26 EXF82526.1 - 1.3e-46 156.9 4.8 6e-12 45.8 0.0 4.5 4 0 0 4 4 4 4 Heavy-metal-associated domain Hydrolase PF00702.26 EXF82526.1 - 7.7e-38 130.9 2.1 7.7e-38 130.9 2.1 1.8 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EXF82526.1 - 6.6e-05 22.8 1.6 0.00037 20.3 0.3 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 EXF82526.1 - 0.083 13.3 0.0 0.2 12.0 0.0 1.6 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase FAM70 PF14967.6 EXF82526.1 - 0.096 12.1 0.3 27 4.1 0.0 3.3 3 0 0 3 3 3 0 FAM70 protein RelB_N PF18506.1 EXF82526.1 - 9.5 6.1 9.8 63 3.5 0.1 4.1 4 0 0 4 4 4 0 RelB Antitoxin alpha helical domain PCI PF01399.27 EXF82527.1 - 9.2e-07 29.3 0.0 1.8e-06 28.4 0.0 1.6 1 0 0 1 1 1 1 PCI domain CSN7a_helixI PF18392.1 EXF82527.1 - 0.019 14.9 0.0 0.038 13.9 0.0 1.5 1 0 0 1 1 1 0 COP9 signalosome complex subunit 7a helix I domain RGS PF00615.19 EXF82528.1 - 8.7e-12 45.4 0.0 4.4e-10 39.9 0.0 2.3 1 1 0 1 1 1 1 Regulator of G protein signaling domain RR_TM4-6 PF06459.12 EXF82528.1 - 0.18 11.6 0.4 0.3 10.9 0.4 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Ribosomal_L31e PF01198.19 EXF82529.1 - 4e-39 132.7 0.3 5.6e-39 132.3 0.3 1.2 1 0 0 1 1 1 1 Ribosomal protein L31e UQ_con PF00179.26 EXF82530.1 - 1.4e-47 160.9 0.0 1.6e-47 160.7 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EXF82530.1 - 1.2e-05 25.0 0.0 1.6e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 EXF82530.1 - 0.01 16.1 0.0 0.014 15.6 0.0 1.4 1 1 0 1 1 1 0 RWD domain UEV PF05743.13 EXF82530.1 - 0.028 14.3 0.0 0.045 13.6 0.0 1.4 1 1 0 1 1 1 0 UEV domain C1_2 PF03107.16 EXF82531.1 - 0.00033 20.9 6.7 0.00069 19.9 6.7 1.6 1 0 0 1 1 1 1 C1 domain DUF285 PF03382.14 EXF82531.1 - 0.0042 16.8 0.0 0.0074 16.0 0.0 1.3 1 0 0 1 1 1 1 Mycoplasma protein of unknown function, DUF285 zf-HIT PF04438.16 EXF82531.1 - 0.95 9.4 12.6 1.7 8.6 12.6 1.5 1 0 0 1 1 1 0 HIT zinc finger Pkinase PF00069.25 EXF82532.1 - 3.5e-58 197.0 0.0 4.6e-58 196.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF82532.1 - 5.8e-28 97.9 0.0 8.9e-28 97.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EXF82532.1 - 4.4e-07 29.5 0.0 6.5e-07 29.0 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EXF82532.1 - 0.064 13.2 0.0 2.9 7.7 0.0 2.3 2 0 0 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.14 EXF82532.1 - 0.072 12.4 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF3613 PF12266.8 EXF82533.1 - 0.18 11.6 1.3 0.41 10.5 1.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3613) SprT-like PF10263.9 EXF82533.1 - 0.43 10.4 2.0 0.43 10.4 1.1 1.7 1 1 0 1 1 1 0 SprT-like family TRI5 PF06330.11 EXF82534.1 - 5.5e-05 22.2 0.0 0.0001 21.3 0.0 1.4 1 0 0 1 1 1 1 Trichodiene synthase (TRI5) HET PF06985.11 EXF82535.1 - 5.6e-23 81.9 0.0 1.1e-17 64.8 0.0 2.4 2 0 0 2 2 2 2 Heterokaryon incompatibility protein (HET) FAD_binding_4 PF01565.23 EXF82536.1 - 1.1e-19 70.6 3.7 1.7e-19 69.9 1.7 2.1 2 0 0 2 2 2 1 FAD binding domain BBE PF08031.12 EXF82536.1 - 5.1e-05 23.3 0.2 0.00011 22.3 0.2 1.5 1 0 0 1 1 1 1 Berberine and berberine like YqhR PF11085.8 EXF82537.1 - 0.1 12.5 2.0 0.23 11.4 0.9 2.1 1 1 1 2 2 2 0 Conserved membrane protein YqhR ThuA PF06283.11 EXF82539.1 - 2.7e-48 165.0 1.0 1.7e-46 159.1 1.0 2.0 1 1 0 1 1 1 1 Trehalose utilisation LysM PF01476.20 EXF82540.1 - 8.3e-20 70.6 3.2 3.7e-07 30.1 0.2 3.2 3 0 0 3 3 3 3 LysM domain UPF0203 PF05254.12 EXF82540.1 - 0.076 13.3 4.0 4.8 7.5 0.4 2.6 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0203) Glyco_hydro_18 PF00704.28 EXF82542.1 - 7.7e-46 157.2 0.5 1.5e-45 156.3 0.5 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Hce2 PF14856.6 EXF82542.1 - 6.7e-28 97.0 0.9 2.1e-27 95.4 0.9 2.0 1 0 0 1 1 1 1 Pathogen effector; putative necrosis-inducing factor LysM PF01476.20 EXF82542.1 - 1.2e-06 28.5 0.0 0.024 14.7 0.0 3.0 2 0 0 2 2 2 2 LysM domain Chitin_bind_1 PF00187.19 EXF82542.1 - 2e-05 24.9 8.6 2e-05 24.9 8.6 3.4 2 1 0 2 2 2 1 Chitin recognition protein CDC45 PF02724.14 EXF82543.1 - 1.6 6.9 4.9 2.1 6.5 4.9 1.2 1 0 0 1 1 1 0 CDC45-like protein OPT PF03169.15 EXF82544.1 - 5.2e-166 553.9 54.9 6e-166 553.7 54.9 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein 3HCDH_N PF02737.18 EXF82545.1 - 4.9e-29 101.5 0.0 7.1e-29 101.0 0.0 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 EXF82545.1 - 3e-12 47.0 0.0 5.5e-12 46.1 0.0 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain AlaDh_PNT_C PF01262.21 EXF82545.1 - 0.13 11.5 0.0 5.3 6.3 0.0 2.2 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain Histidinol_dh PF00815.20 EXF82546.1 - 2.1e-138 461.8 0.0 2.5e-138 461.5 0.0 1.0 1 0 0 1 1 1 1 Histidinol dehydrogenase FlbD PF06289.11 EXF82546.1 - 0.04 13.5 0.0 0.12 12.0 0.0 1.8 1 0 0 1 1 1 0 Flagellar and Swarming motility proteins Fungal_trans PF04082.18 EXF82547.1 - 0.0023 17.0 0.4 0.0039 16.3 0.4 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Acyl_transf_3 PF01757.22 EXF82548.1 - 1.8e-26 93.0 33.6 8.3e-26 90.8 33.6 1.9 1 1 0 1 1 1 1 Acyltransferase family DUF3176 PF11374.8 EXF82549.1 - 5.4e-31 107.0 4.3 5.4e-31 107.0 4.3 2.1 3 0 0 3 3 3 1 Protein of unknown function (DUF3176) PRIMA1 PF16101.5 EXF82549.1 - 1.7 8.7 4.1 3.3 7.8 4.1 1.4 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 CPBP PF02517.16 EXF82549.1 - 2.1 8.8 4.7 7.1 7.1 2.0 2.4 2 0 0 2 2 2 0 CPBP intramembrane metalloprotease Dioxygenase_N PF04444.14 EXF82550.1 - 2.4e-21 75.4 0.0 3.3e-21 74.9 0.0 1.2 1 0 0 1 1 1 1 Catechol dioxygenase N terminus DUF3138 PF11336.8 EXF82551.1 - 3.7 6.0 8.0 0.17 10.5 1.8 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3138) WD40 PF00400.32 EXF82552.1 - 1.5e-58 193.4 14.5 1e-08 35.7 0.1 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat Tup_N PF08581.10 EXF82552.1 - 3.9e-17 62.3 11.1 6.7e-17 61.6 11.1 1.4 1 0 0 1 1 1 1 Tup N-terminal ANAPC4_WD40 PF12894.7 EXF82552.1 - 7.7e-15 55.0 0.0 0.00048 20.4 0.0 5.3 2 1 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EXF82552.1 - 3.1e-07 29.7 0.2 0.18 10.7 0.0 5.0 2 2 3 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 EXF82552.1 - 4.8e-05 22.8 0.0 0.38 10.0 0.0 4.4 4 1 1 5 5 5 1 WD40-like domain Nup160 PF11715.8 EXF82552.1 - 0.019 13.6 0.3 2.7 6.5 0.0 3.3 1 1 3 4 4 4 0 Nucleoporin Nup120/160 Golgin_A5 PF09787.9 EXF82552.1 - 0.025 14.1 4.0 0.036 13.5 4.0 1.1 1 0 0 1 1 1 0 Golgin subfamily A member 5 PD40 PF07676.12 EXF82552.1 - 0.026 14.5 0.0 9.9 6.2 0.0 4.1 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 EXF82552.1 - 0.035 12.6 0.4 0.34 9.4 0.2 2.3 1 1 1 2 2 2 0 Cytochrome D1 heme domain Nbas_N PF15492.6 EXF82552.1 - 0.048 13.0 0.1 19 4.4 0.0 3.0 2 1 1 3 3 3 0 Neuroblastoma-amplified sequence, N terminal LXG PF04740.12 EXF82552.1 - 0.08 12.6 1.9 0.13 12.0 1.9 1.2 1 0 0 1 1 1 0 LXG domain of WXG superfamily Nucleoporin_N PF08801.11 EXF82552.1 - 0.09 11.5 0.1 5.3 5.7 0.1 3.2 2 1 1 3 3 3 0 Nup133 N terminal like Tektin PF03148.14 EXF82552.1 - 0.19 10.5 3.3 0.26 10.0 3.3 1.1 1 0 0 1 1 1 0 Tektin family SHE3 PF17078.5 EXF82552.1 - 0.22 11.2 4.7 0.32 10.7 4.7 1.1 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 TSNAXIP1_N PF15739.5 EXF82552.1 - 0.49 10.8 4.8 0.82 10.1 4.8 1.2 1 0 0 1 1 1 0 Translin-associated factor X-interacting N-terminus TPX2 PF06886.11 EXF82552.1 - 2.8 8.2 10.4 57 4.0 10.4 2.1 1 1 0 1 1 1 0 Targeting protein for Xklp2 (TPX2) FA_hydroxylase PF04116.13 EXF82553.1 - 1.3e-24 87.1 15.5 1.3e-24 87.1 15.5 2.4 2 1 0 2 2 2 2 Fatty acid hydroxylase superfamily DUF5543 PF17697.1 EXF82553.1 - 0.19 12.0 0.0 0.34 11.2 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5543) MMtag PF10159.9 EXF82553.1 - 0.19 12.0 0.9 0.36 11.2 0.9 1.3 1 0 0 1 1 1 0 Multiple myeloma tumor-associated DUF2015 PF09435.10 EXF82554.1 - 1.1e-47 160.5 0.0 1.2e-47 160.3 0.0 1.0 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF2015) Ribosomal_L28e PF01778.17 EXF82555.1 - 1e-33 116.5 0.1 1.3e-33 116.2 0.1 1.1 1 0 0 1 1 1 1 Ribosomal L28e protein family Ldh_1_C PF02866.18 EXF82556.1 - 5.5e-50 169.6 0.0 7.7e-50 169.1 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.23 EXF82556.1 - 4.2e-44 150.1 0.2 6.1e-44 149.5 0.2 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain 3Beta_HSD PF01073.19 EXF82556.1 - 0.0012 17.9 0.0 0.0018 17.4 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family TRAPP PF04051.16 EXF82557.1 - 6.2e-46 155.7 0.0 1e-45 155.0 0.0 1.4 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component PINIT PF14324.6 EXF82557.1 - 4.4e-43 147.1 0.1 7.4e-43 146.4 0.1 1.4 1 0 0 1 1 1 1 PINIT domain zf-MIZ PF02891.20 EXF82557.1 - 1.5e-22 79.1 5.9 3.2e-22 78.0 5.9 1.6 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-Nse PF11789.8 EXF82557.1 - 6.1e-06 26.0 1.6 1.2e-05 25.0 1.6 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit SAP PF02037.27 EXF82557.1 - 0.0014 18.3 0.0 0.0033 17.1 0.0 1.6 1 0 0 1 1 1 1 SAP domain zf-C3HC4_4 PF15227.6 EXF82557.1 - 0.073 13.3 5.7 0.17 12.1 5.7 1.7 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-Sec23_Sec24 PF04810.15 EXF82557.1 - 0.087 12.9 1.0 0.24 11.5 0.7 1.9 1 1 0 1 1 1 0 Sec23/Sec24 zinc finger zf-RING_5 PF14634.6 EXF82557.1 - 1.2 9.2 3.2 2.3 8.3 3.2 1.5 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_2 PF13639.6 EXF82557.1 - 1.7 9.1 4.7 3.4 8.1 4.7 1.5 1 0 0 1 1 1 0 Ring finger domain DUF2423 PF10338.9 EXF82558.1 - 4.2e-20 71.7 3.7 4.2e-20 71.7 3.7 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF2423) DUF3982 PF13138.6 EXF82558.1 - 0.098 12.5 0.1 0.2 11.5 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3982) CagS PF16707.5 EXF82559.1 - 0.073 13.1 0.0 0.12 12.4 0.0 1.2 1 0 0 1 1 1 0 Cag pathogenicity island protein S of Helicobacter pylori SGL PF08450.12 EXF82561.1 - 0.0005 19.7 0.0 0.0017 18.0 0.0 1.9 2 0 0 2 2 2 1 SMP-30/Gluconolactonase/LRE-like region Peptidase_M23 PF01551.22 EXF82561.1 - 0.059 13.6 0.1 5.7 7.2 0.0 2.6 2 0 0 2 2 2 0 Peptidase family M23 DUF4805 PF16063.5 EXF82561.1 - 0.072 12.4 0.0 1.8 7.8 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4805) RCC1_2 PF13540.6 EXF82561.1 - 0.15 11.9 1.0 17 5.4 0.3 2.7 2 0 0 2 2 2 0 Regulator of chromosome condensation (RCC1) repeat GFA PF04828.14 EXF82562.1 - 1.6e-10 41.2 2.8 2.5e-05 24.5 0.0 3.0 3 0 0 3 3 3 2 Glutathione-dependent formaldehyde-activating enzyme Nudix_N_2 PF14803.6 EXF82562.1 - 0.018 15.0 2.7 7.3 6.6 0.1 3.6 3 0 0 3 3 3 0 Nudix N-terminal zf-NADH-PPase PF09297.11 EXF82562.1 - 0.051 13.2 0.0 0.051 13.2 0.0 2.6 3 0 0 3 3 3 0 NADH pyrophosphatase zinc ribbon domain zinc_ribbon_2 PF13240.6 EXF82562.1 - 1.1 9.1 9.7 3.8 7.4 0.5 3.3 3 0 0 3 3 3 0 zinc-ribbon domain Tmemb_9 PF05434.11 EXF82562.1 - 4.3 7.2 5.8 3.9 7.4 0.3 2.3 2 0 0 2 2 2 0 TMEM9 2OG-FeII_Oxy_2 PF13532.6 EXF82563.1 - 3.4e-36 125.3 0.0 4.5e-36 124.9 0.0 1.2 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily zf-GRF PF06839.12 EXF82563.1 - 2.2e-10 40.4 6.0 3.9e-10 39.7 6.0 1.4 1 0 0 1 1 1 1 GRF zinc finger MIF4G PF02854.19 EXF82563.1 - 0.12 12.0 0.0 0.19 11.4 0.0 1.2 1 0 0 1 1 1 0 MIF4G domain WD40 PF00400.32 EXF82564.1 - 3e-16 59.5 13.5 0.00099 19.9 0.0 6.6 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EXF82564.1 - 0.00017 21.8 0.1 0.32 11.3 0.0 3.8 2 2 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 EXF82564.1 - 0.04 13.9 0.0 0.37 10.8 0.0 2.4 3 0 0 3 3 3 0 Ciliary BBSome complex subunit 2, middle region DEAD PF00270.29 EXF82565.1 - 1.1e-42 145.7 0.1 2.8e-42 144.5 0.0 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EXF82565.1 - 3.1e-20 72.6 0.1 7.8e-20 71.3 0.1 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 EXF82565.1 - 0.0014 17.9 0.1 0.0023 17.2 0.1 1.2 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase ResIII PF04851.15 EXF82565.1 - 0.028 14.4 0.0 0.059 13.4 0.0 1.5 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_18 PF13238.6 EXF82566.1 - 0.11 13.0 0.2 0.49 11.0 0.2 2.0 1 1 0 1 1 1 0 AAA domain SprA-related PF12118.8 EXF82566.1 - 2.7 7.0 12.7 3.6 6.6 11.2 1.7 1 1 1 2 2 2 0 SprA-related family Abhydrolase_6 PF12697.7 EXF82567.1 - 1.5e-07 32.2 0.2 1e-06 29.5 0.0 2.1 2 0 0 2 2 2 1 Alpha/beta hydrolase family DUF1100 PF06500.11 EXF82567.1 - 1.8e-07 30.3 0.0 2.5e-07 29.9 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1100) Peptidase_S9 PF00326.21 EXF82567.1 - 4.2e-06 26.4 0.0 1.2e-05 24.9 0.0 1.7 1 0 0 1 1 1 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 EXF82567.1 - 3.4e-05 23.2 0.0 6.3e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EXF82567.1 - 0.00024 20.8 0.0 0.00068 19.4 0.0 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold AXE1 PF05448.12 EXF82567.1 - 0.00073 18.3 0.0 0.0025 16.5 0.0 1.7 2 0 0 2 2 2 1 Acetyl xylan esterase (AXE1) DUF2920 PF11144.8 EXF82567.1 - 0.032 13.4 0.0 0.054 12.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2920) UPF0227 PF05728.12 EXF82567.1 - 0.091 12.7 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) BAAT_C PF08840.11 EXF82567.1 - 0.093 12.6 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal Peptidase_M75 PF09375.10 EXF82567.1 - 0.24 10.8 4.4 0.38 10.2 4.4 1.2 1 0 0 1 1 1 0 Imelysin Zn_clus PF00172.18 EXF82568.1 - 1.3e-06 28.4 13.1 2.6e-06 27.4 13.1 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain p450 PF00067.22 EXF82569.1 - 3.7e-64 217.2 0.0 4.6e-64 216.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 polyprenyl_synt PF00348.17 EXF82570.1 - 1e-49 168.9 0.0 2.1e-49 167.9 0.0 1.4 1 0 0 1 1 1 1 Polyprenyl synthetase FAD_binding_4 PF01565.23 EXF82571.1 - 1.5e-23 83.1 4.8 3.2e-23 82.0 4.8 1.6 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EXF82571.1 - 0.002 18.2 0.2 0.0046 17.0 0.2 1.6 1 0 0 1 1 1 1 Berberine and berberine like MBOAT_2 PF13813.6 EXF82572.1 - 9e-18 64.3 3.3 2.1e-17 63.2 3.3 1.7 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family Cys_rich_CPCC PF14206.6 EXF82573.1 - 5.5 6.9 7.6 0.25 11.2 1.1 2.0 2 0 0 2 2 2 0 Cysteine-rich CPCC Mito_carr PF00153.27 EXF82574.1 - 2.5e-39 133.1 6.9 1.3e-16 60.3 0.3 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 EXF82574.1 - 0.0031 16.7 0.1 0.0077 15.4 0.1 1.6 1 0 0 1 1 1 1 Gammaproteobacterial serine protease Metallophos PF00149.28 EXF82576.1 - 8.2e-11 42.8 0.8 1.7e-10 41.7 0.8 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase 5_nucleotid_C PF02872.18 EXF82576.1 - 0.086 13.1 0.0 0.26 11.5 0.0 1.7 1 1 0 1 1 1 0 5'-nucleotidase, C-terminal domain Glyco_hydro_28 PF00295.17 EXF82577.1 - 4.7e-22 78.5 8.0 1.3e-19 70.4 3.5 2.4 2 1 0 2 2 2 2 Glycosyl hydrolases family 28 Beta_helix PF13229.6 EXF82577.1 - 0.0033 17.3 15.0 0.011 15.6 6.8 2.8 2 1 0 3 3 3 2 Right handed beta helix region Polysacc_deac_1 PF01522.21 EXF82578.1 - 3.9e-33 114.0 0.0 6.8e-33 113.2 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide deacetylase Chitin_bind_1 PF00187.19 EXF82578.1 - 9.9e-18 64.3 45.7 2.2e-09 37.6 18.3 2.6 2 0 0 2 2 2 2 Chitin recognition protein Glyco_hydro_57 PF03065.15 EXF82578.1 - 9.6e-07 28.3 0.0 2.5e-06 26.9 0.0 1.6 2 1 0 2 2 2 1 Glycosyl hydrolase family 57 DUF2334 PF10096.9 EXF82578.1 - 0.15 11.7 0.1 0.65 9.6 0.1 1.8 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2334) Pkinase PF00069.25 EXF82579.1 - 2.3e-11 43.6 0.0 3.8e-11 42.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF82579.1 - 2.4e-05 23.8 0.0 0.00012 21.4 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase TSNAXIP1_N PF15739.5 EXF82579.1 - 0.04 14.3 0.8 0.089 13.2 0.8 1.5 1 0 0 1 1 1 0 Translin-associated factor X-interacting N-terminus CorA PF01544.18 EXF82580.1 - 0.1 11.9 4.0 0.069 12.5 1.8 1.7 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein zf-P11 PF03854.14 EXF82581.1 - 0.0061 16.2 3.3 0.01 15.5 3.3 1.3 1 0 0 1 1 1 1 P-11 zinc finger COX16 PF14138.6 EXF82582.1 - 1.1e-33 115.6 0.3 1.5e-33 115.1 0.3 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein COX16 zf-C2H2_4 PF13894.6 EXF82583.1 - 0.0012 19.5 20.3 0.018 15.9 4.0 4.8 5 0 0 5 5 5 2 C2H2-type zinc finger zf-C2H2 PF00096.26 EXF82583.1 - 0.091 13.3 23.3 3.7 8.2 0.2 5.1 5 0 0 5 5 5 0 Zinc finger, C2H2 type Arginase PF00491.21 EXF82583.1 - 0.15 11.5 0.0 0.25 10.8 0.0 1.2 1 0 0 1 1 1 0 Arginase family zf-C2H2_jaz PF12171.8 EXF82583.1 - 0.22 11.9 12.8 3 8.2 3.6 3.8 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EXF82583.1 - 0.24 11.9 4.5 2.2 8.8 0.5 3.1 2 0 0 2 2 2 0 Zinc-finger of C2H2 type DUF629 PF04780.12 EXF82583.1 - 3.2 6.2 6.5 3.1 6.2 3.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF629) Kelch_3 PF13415.6 EXF82584.1 - 1.9e-23 82.2 14.1 2.7e-06 27.5 0.2 7.3 8 1 0 8 8 8 5 Galactose oxidase, central domain Kelch_6 PF13964.6 EXF82584.1 - 3.1e-22 78.1 1.9 3e-08 33.7 0.1 5.0 5 0 0 5 5 5 3 Kelch motif Kelch_4 PF13418.6 EXF82584.1 - 8.3e-22 76.9 13.5 3.9e-07 30.0 0.1 6.8 7 0 0 7 7 7 4 Galactose oxidase, central domain Kelch_5 PF13854.6 EXF82584.1 - 9.9e-17 60.5 4.5 6e-05 22.9 0.0 6.6 7 0 0 7 7 7 4 Kelch motif Kelch_1 PF01344.25 EXF82584.1 - 1.9e-14 53.0 13.2 5.3e-07 29.1 0.0 5.5 7 0 0 7 7 7 3 Kelch motif Kelch_2 PF07646.15 EXF82584.1 - 1e-11 44.3 7.5 4.4e-06 26.4 0.8 5.9 5 1 0 5 5 5 3 Kelch motif 2Fe-2S_thioredx PF01257.19 EXF82585.1 - 2.6e-58 196.0 0.0 3.4e-58 195.6 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin-like [2Fe-2S] ferredoxin AMP-binding PF00501.28 EXF82587.1 - 1.2e-91 307.5 0.1 1.4e-91 307.2 0.1 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EXF82587.1 - 1.1e-10 42.3 0.1 2.4e-10 41.2 0.1 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain SAGA-Tad1 PF12767.7 EXF82588.1 - 5.8e-60 203.0 0.0 7.4e-60 202.6 0.0 1.1 1 0 0 1 1 1 1 Transcriptional regulator of RNA polII, SAGA, subunit GCP_C_terminal PF04130.13 EXF82589.1 - 8.4e-101 337.5 0.0 1.3e-100 336.9 0.0 1.3 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal GCP_N_terminal PF17681.1 EXF82589.1 - 4.4e-84 282.7 0.0 1.5e-83 281.0 0.0 1.8 2 0 0 2 2 2 1 Gamma tubulin complex component N-terminal ATP-synt_DE_N PF02823.16 EXF82590.1 - 5.3e-18 64.7 0.0 8.7e-18 64.0 0.0 1.3 1 0 0 1 1 1 1 ATP synthase, Delta/Epsilon chain, beta-sandwich domain NOB1_Zn_bind PF08772.11 EXF82591.1 - 0.0017 18.5 1.8 0.0042 17.2 1.8 1.6 1 0 0 1 1 1 1 Nin one binding (NOB1) Zn-ribbon like FYVE PF01363.21 EXF82591.1 - 0.0026 17.9 3.9 0.0059 16.7 3.9 1.6 1 0 0 1 1 1 1 FYVE zinc finger Siva PF05458.12 EXF82591.1 - 0.006 16.3 2.3 0.006 16.3 2.3 1.9 2 0 0 2 2 2 1 Cd27 binding protein (Siva) Zn_Tnp_IS91 PF14319.6 EXF82591.1 - 0.0074 16.3 1.0 0.0074 16.3 1.0 1.8 2 0 0 2 2 2 1 Transposase zinc-binding domain zf-C3HC4 PF00097.25 EXF82591.1 - 0.01 15.7 4.4 0.02 14.8 4.4 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EXF82591.1 - 0.015 15.1 4.3 0.028 14.3 4.3 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DZR PF12773.7 EXF82591.1 - 0.27 11.3 8.1 1.4 9.0 8.1 2.1 1 1 0 1 1 1 0 Double zinc ribbon DUF2321 PF10083.9 EXF82591.1 - 0.65 9.6 3.6 1.9 8.1 3.4 1.8 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2321) zinc_ribbon_2 PF13240.6 EXF82591.1 - 1.6 8.6 11.9 0.46 10.3 3.4 2.9 2 1 1 3 3 3 0 zinc-ribbon domain Zn-ribbon_8 PF09723.10 EXF82591.1 - 5.1 7.3 7.0 14 5.9 7.0 1.7 1 0 0 1 1 1 0 Zinc ribbon domain Peptidase_M2 PF01401.18 EXF82592.1 - 0.65 8.6 5.6 0.12 11.0 2.1 1.5 2 0 0 2 2 2 0 Angiotensin-converting enzyme DnaJ PF00226.31 EXF82593.1 - 8.2e-16 57.9 1.2 2.7e-15 56.2 1.2 1.9 1 0 0 1 1 1 1 DnaJ domain Sec63 PF02889.16 EXF82593.1 - 3.9e-11 42.6 0.0 8.4e-10 38.2 0.0 2.5 2 1 0 2 2 2 1 Sec63 Brl domain MCR_D PF02505.14 EXF82593.1 - 0.065 13.1 0.3 0.19 11.6 0.1 1.8 2 0 0 2 2 2 0 Methyl-coenzyme M reductase operon protein D DUF4045 PF13254.6 EXF82594.1 - 1.5e-93 314.8 47.4 1e-58 200.0 35.8 8.1 3 3 5 8 8 8 2 Domain of unknown function (DUF4045) Gelsolin PF00626.22 EXF82594.1 - 6.7e-07 29.1 0.0 0.021 14.7 0.0 3.3 3 0 0 3 3 3 2 Gelsolin repeat Arf PF00025.21 EXF82595.1 - 2.5e-67 225.7 0.7 2.8e-67 225.5 0.7 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 EXF82595.1 - 1.3e-12 47.6 0.8 3.4e-07 29.8 0.1 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 EXF82595.1 - 1.6e-12 47.3 0.0 1.9e-12 47.1 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EXF82595.1 - 2.1e-12 47.3 0.1 2.9e-12 46.9 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 EXF82595.1 - 2.7e-10 40.0 0.0 3.2e-10 39.8 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EXF82595.1 - 2.6e-08 33.9 0.0 4.1e-08 33.3 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 EXF82595.1 - 3.2e-08 33.2 0.0 3.7e-08 33.0 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 EXF82595.1 - 0.0001 21.9 0.0 0.002 17.7 0.0 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain NACHT PF05729.12 EXF82595.1 - 0.02 14.8 0.3 0.22 11.4 0.0 2.0 2 0 0 2 2 2 0 NACHT domain FeoB_N PF02421.18 EXF82595.1 - 0.029 13.9 0.3 0.058 12.9 0.3 1.7 1 1 0 1 1 1 0 Ferrous iron transport protein B Dynamin_N PF00350.23 EXF82595.1 - 0.064 13.3 0.0 0.75 9.8 0.0 2.0 2 0 0 2 2 2 0 Dynamin family 6PF2K PF01591.18 EXF82595.1 - 0.13 11.5 0.0 0.31 10.3 0.0 1.6 2 0 0 2 2 2 0 6-phosphofructo-2-kinase Acetyltransf_7 PF13508.7 EXF82596.1 - 0.00026 21.4 0.0 0.0011 19.4 0.0 2.0 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EXF82596.1 - 0.019 15.2 0.0 0.05 13.8 0.0 1.8 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Acetyltransf_13 PF13880.6 EXF82596.1 - 0.11 12.5 0.0 0.3 11.1 0.0 1.7 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase RRXRR PF14239.6 EXF82597.1 - 0.06 13.2 2.3 0.11 12.4 2.3 1.3 1 0 0 1 1 1 0 RRXRR protein DUF2791 PF10923.8 EXF82597.1 - 0.2 10.5 0.0 0.28 10.0 0.0 1.1 1 0 0 1 1 1 0 P-loop Domain of unknown function (DUF2791) Spem1 PF15670.5 EXF82597.1 - 0.43 10.1 2.2 1.1 8.8 1.0 2.2 3 0 0 3 3 3 0 Spermatid maturation protein 1 Pkinase PF00069.25 EXF82598.1 - 8.4e-52 176.1 0.0 2.2e-51 174.8 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF82598.1 - 5.9e-20 71.6 0.0 2.6e-19 69.5 0.0 2.0 2 1 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 EXF82598.1 - 0.02 14.2 0.3 6 6.1 0.1 2.4 2 0 0 2 2 2 0 Kinase-like Mtc PF03820.17 EXF82599.1 - 4.2e-119 397.2 0.2 4.8e-119 397.0 0.2 1.0 1 0 0 1 1 1 1 Tricarboxylate carrier GMC_oxred_N PF00732.19 EXF82600.1 - 2e-57 194.9 0.0 2.9e-57 194.3 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EXF82600.1 - 2.1e-29 102.9 0.3 4.5e-29 101.8 0.1 1.7 2 0 0 2 2 2 1 GMC oxidoreductase Lycopene_cycl PF05834.12 EXF82600.1 - 0.0002 20.5 0.0 0.00041 19.5 0.0 1.5 1 0 0 1 1 1 1 Lycopene cyclase protein DAO PF01266.24 EXF82600.1 - 0.0051 16.4 0.1 2.2 7.8 0.1 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EXF82600.1 - 0.0082 15.3 0.1 0.69 8.9 0.0 2.1 2 0 0 2 2 2 2 FAD binding domain Pyr_redox_2 PF07992.14 EXF82600.1 - 0.016 14.5 0.0 0.88 8.7 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EXF82600.1 - 0.016 14.3 0.1 0.63 9.1 0.0 2.2 2 0 0 2 2 2 0 Glucose inhibited division protein A NAD_binding_8 PF13450.6 EXF82600.1 - 0.027 14.7 0.0 0.073 13.3 0.0 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain adh_short PF00106.25 EXF82604.1 - 7.8e-23 80.9 0.0 3.4e-16 59.3 0.0 2.2 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EXF82604.1 - 1.6e-13 50.7 0.0 2.2e-11 43.7 0.0 2.2 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF82604.1 - 8.9e-08 32.3 0.0 1.7e-07 31.4 0.0 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EXF82604.1 - 7.9e-05 22.2 0.0 0.00015 21.4 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EXF82604.1 - 0.0067 15.6 0.0 0.01 15.0 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein DUF1593 PF07632.11 EXF82605.1 - 7.4e-88 294.3 0.0 9.8e-88 293.9 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1593) REJ PF02010.15 EXF82605.1 - 0.0057 15.5 0.0 0.0081 15.0 0.0 1.2 1 0 0 1 1 1 1 REJ domain Sugar_tr PF00083.24 EXF82606.1 - 1.3e-64 218.7 19.7 1.2e-39 136.5 6.5 2.0 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 EXF82606.1 - 1.3e-13 50.6 38.2 2e-12 46.7 29.5 3.1 1 1 2 3 3 3 3 Major Facilitator Superfamily adh_short PF00106.25 EXF82607.1 - 6.7e-37 126.8 0.0 9.4e-37 126.4 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF82607.1 - 7.9e-23 81.2 0.0 1.1e-22 80.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF82607.1 - 3.1e-09 37.0 0.2 6.7e-05 22.9 0.0 2.2 2 0 0 2 2 2 2 KR domain Epimerase PF01370.21 EXF82607.1 - 5.9e-05 22.6 0.0 0.00011 21.7 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 EXF82607.1 - 0.0013 17.9 0.0 0.0025 17.0 0.0 1.4 1 1 0 1 1 1 1 RmlD substrate binding domain FtsJ PF01728.19 EXF82607.1 - 0.0085 16.2 0.0 0.011 15.9 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase Peptidase_S15 PF02129.18 EXF82608.1 - 2.7e-15 56.7 0.2 3.7e-15 56.2 0.2 1.3 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Peptidase_S9 PF00326.21 EXF82608.1 - 3.8e-11 42.9 0.0 6.8e-11 42.1 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 EXF82608.1 - 4e-11 42.6 0.1 5.6e-11 42.2 0.1 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EXF82608.1 - 3.5e-09 37.6 10.9 2.7e-08 34.7 10.8 1.9 1 1 1 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EXF82608.1 - 3.4e-06 26.9 0.0 1.2e-05 25.1 0.1 1.7 1 1 1 2 2 2 1 alpha/beta hydrolase fold AXE1 PF05448.12 EXF82608.1 - 7.7e-06 24.8 0.0 0.00047 18.9 0.0 2.1 1 1 0 1 1 1 1 Acetyl xylan esterase (AXE1) DUF1100 PF06500.11 EXF82608.1 - 0.00095 18.1 0.0 0.0012 17.7 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1100) Abhydrolase_3 PF07859.13 EXF82608.1 - 0.0014 18.5 0.0 0.0026 17.7 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold WSC PF01822.19 EXF82609.1 - 3.1e-47 158.7 38.4 2.6e-20 72.4 13.2 3.4 3 0 0 3 3 3 3 WSC domain Amidase PF01425.21 EXF82610.1 - 3.3e-31 108.8 1.9 5.9e-31 107.9 1.9 1.3 1 0 0 1 1 1 1 Amidase GREB1 PF15782.5 EXF82611.1 - 3.5 4.6 19.2 4.7 4.2 19.2 1.3 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer PX PF00787.24 EXF82612.1 - 1.2e-16 60.7 0.0 1.9e-16 60.1 0.0 1.3 1 0 0 1 1 1 1 PX domain SlyX PF04102.12 EXF82612.1 - 1 10.0 5.1 2.4 8.8 0.2 2.7 1 1 1 2 2 2 0 SlyX EB1 PF03271.17 EXF82613.1 - 4.6e-17 62.0 2.1 9.2e-17 61.0 2.1 1.5 1 0 0 1 1 1 1 EB1-like C-terminal motif CH PF00307.31 EXF82613.1 - 1.1e-06 28.8 0.9 2e-06 27.9 0.9 1.4 1 0 0 1 1 1 1 Calponin homology (CH) domain CH_2 PF06294.11 EXF82613.1 - 0.079 13.1 0.2 0.18 12.0 0.2 1.6 1 0 0 1 1 1 0 CH-like domain in sperm protein DEAD PF00270.29 EXF82614.1 - 1.4e-45 155.2 1.0 2.4e-45 154.5 0.1 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EXF82614.1 - 2e-30 105.4 0.9 1.3e-29 102.8 0.2 2.5 3 0 0 3 3 3 1 Helicase conserved C-terminal domain UTP25 PF06862.12 EXF82614.1 - 0.00012 21.1 1.6 0.00034 19.5 0.1 2.3 1 1 2 3 3 3 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 DUF2802 PF10975.8 EXF82614.1 - 1.5 9.0 5.2 8.9 6.5 2.2 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2802) Pectate_lyase PF03211.13 EXF82615.1 - 2.7e-76 255.7 10.8 3.7e-76 255.2 10.8 1.1 1 0 0 1 1 1 1 Pectate lyase Tombus_movement PF05318.12 EXF82615.1 - 4.6 8.1 7.7 50 4.8 5.2 2.7 2 0 0 2 2 2 0 Tombusvirus movement protein BTRD1 PF17660.1 EXF82616.1 - 1.6e-35 120.6 1.0 2.7e-15 55.9 0.1 4.2 4 0 0 4 4 4 3 Bacterial tandem repeat domain 1 Beta-lactamase PF00144.24 EXF82616.1 - 4.2e-35 121.6 0.3 6.5e-35 120.9 0.3 1.2 1 0 0 1 1 1 1 Beta-lactamase p450 PF00067.22 EXF82617.1 - 2e-69 234.5 0.0 2.7e-69 234.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Hira PF07569.11 EXF82617.1 - 0.02 14.6 0.1 0.24 11.1 0.0 2.2 2 0 0 2 2 2 0 TUP1-like enhancer of split Sugar_tr PF00083.24 EXF82618.1 - 7.3e-98 328.4 17.9 8.6e-98 328.1 17.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF82618.1 - 4.6e-34 117.9 41.5 4e-28 98.4 25.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF3188 PF11384.8 EXF82618.1 - 0.066 12.9 0.4 0.5 10.1 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3188) DUF4017 PF13209.6 EXF82618.1 - 0.79 9.7 6.9 0.47 10.4 0.3 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4017) DUF1206 PF06724.11 EXF82619.1 - 0.28 11.3 3.1 0.4 10.8 1.9 1.9 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1206) adh_short_C2 PF13561.6 EXF82620.1 - 2.8e-61 207.1 2.0 3.2e-61 206.9 2.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF82620.1 - 1.2e-39 135.8 1.3 1.5e-39 135.5 1.3 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EXF82620.1 - 1.1e-14 54.8 0.4 1.6e-14 54.2 0.4 1.2 1 0 0 1 1 1 1 KR domain YjeF_N PF03853.15 EXF82620.1 - 0.033 14.1 0.1 0.089 12.7 0.1 1.7 2 0 0 2 2 2 0 YjeF-related protein N-terminus SRF-TF PF00319.18 EXF82620.1 - 0.069 12.7 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 SRF-type transcription factor (DNA-binding and dimerisation domain) Alpha-2-MRAP_C PF06401.11 EXF82620.1 - 0.076 13.0 0.1 0.45 10.4 0.0 1.9 2 0 0 2 2 2 0 Alpha-2-macroglobulin RAP, C-terminal domain IRF-3 PF10401.9 EXF82621.1 - 0.15 11.9 0.0 0.22 11.3 0.0 1.2 1 0 0 1 1 1 0 Interferon-regulatory factor 3 Glyoxalase_3 PF13468.6 EXF82622.1 - 6.8e-22 78.4 0.0 1.5e-21 77.3 0.0 1.5 2 0 0 2 2 2 1 Glyoxalase-like domain Cellulase PF00150.18 EXF82623.1 - 1.3e-46 159.3 0.0 1.7e-46 158.9 0.0 1.1 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) SOG2 PF10428.9 EXF82623.1 - 2.9 7.0 9.8 3.7 6.6 9.8 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Lactamase_B_4 PF13691.6 EXF82624.1 - 8.8e-21 73.4 0.1 1.9e-19 69.1 0.0 2.4 2 0 0 2 2 2 1 tRNase Z endonuclease Lactamase_B_2 PF12706.7 EXF82624.1 - 1.7e-15 57.1 0.0 3.6e-15 56.0 0.0 1.6 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 EXF82624.1 - 0.0027 17.8 0.0 0.0069 16.4 0.0 1.8 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Flavin_Reduct PF01613.18 EXF82626.1 - 2e-15 57.1 0.0 3.8e-15 56.3 0.0 1.4 1 0 0 1 1 1 1 Flavin reductase like domain PDEase_II PF02112.15 EXF82627.1 - 3.4e-50 171.1 0.2 1.5e-43 149.3 0.3 2.8 2 1 0 2 2 2 2 cAMP phosphodiesterases class-II Lactamase_B_2 PF12706.7 EXF82627.1 - 0.083 12.4 0.0 0.17 11.4 0.0 1.5 1 0 0 1 1 1 0 Beta-lactamase superfamily domain Acyl_transf_3 PF01757.22 EXF82629.1 - 6.9e-31 107.6 28.0 1.6e-30 106.3 28.0 1.6 1 1 0 1 1 1 1 Acyltransferase family AMP-binding PF00501.28 EXF82630.1 - 1.3e-65 221.7 0.4 2.6e-35 121.9 0.0 4.2 2 2 0 2 2 2 2 AMP-binding enzyme Transferase PF02458.15 EXF82632.1 - 1.2e-12 47.2 0.0 1.6e-12 46.9 0.0 1.1 1 0 0 1 1 1 1 Transferase family Glyco_hydro81C PF17652.1 EXF82633.1 - 3.9e-132 440.7 5.2 5.9e-132 440.1 5.2 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 81 C-terminal domain Glyco_hydro_81 PF03639.13 EXF82633.1 - 1e-102 343.6 0.3 1.4e-102 343.2 0.3 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 81 N-terminal domain Glu_cyclase_2 PF05096.12 EXF82633.1 - 0.027 13.9 0.0 0.051 13.0 0.0 1.4 1 0 0 1 1 1 0 Glutamine cyclotransferase Fungal_trans PF04082.18 EXF82634.1 - 2.2e-05 23.7 0.0 2.6e-05 23.4 0.0 1.2 1 1 0 1 1 1 1 Fungal specific transcription factor domain Inhibitor_I48 PF10467.9 EXF82634.1 - 0.22 11.4 0.0 0.32 10.9 0.0 1.2 1 0 0 1 1 1 0 Peptidase inhibitor clitocypin LigB PF02900.18 EXF82635.1 - 1.3e-25 90.0 0.0 1.7e-25 89.6 0.0 1.1 1 0 0 1 1 1 1 Catalytic LigB subunit of aromatic ring-opening dioxygenase Phosphodiest PF01663.22 EXF82636.1 - 6.1e-10 39.2 3.4 1.9e-07 31.0 3.4 2.2 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 EXF82636.1 - 0.0003 20.3 0.0 0.0018 17.8 0.0 1.9 2 0 0 2 2 2 1 Sulfatase Cnd3 PF12719.7 EXF82637.1 - 6.8e-91 304.5 2.4 6.8e-91 304.5 2.4 2.1 2 1 0 2 2 2 1 Nuclear condensing complex subunits, C-term domain HEAT_2 PF13646.6 EXF82637.1 - 3.4e-09 37.0 8.4 4e-05 23.9 1.0 4.5 4 0 0 4 4 4 2 HEAT repeats HEAT PF02985.22 EXF82637.1 - 3e-07 30.1 11.3 0.089 13.1 0.0 8.3 9 0 0 9 9 9 1 HEAT repeat Cnd1 PF12717.7 EXF82637.1 - 0.00083 19.4 5.7 0.4 10.7 0.1 4.4 4 1 1 5 5 5 3 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 EXF82637.1 - 9.8 6.8 15.4 0.81 10.3 0.7 5.3 6 1 1 7 7 7 0 HEAT-like repeat RRM_1 PF00076.22 EXF82638.1 - 1.1e-56 188.6 0.1 2.7e-16 59.2 0.0 5.6 5 0 0 5 5 5 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_Rrp7 PF17799.1 EXF82638.1 - 9.8e-06 25.5 0.5 0.29 10.9 0.1 3.5 2 1 1 3 3 3 2 Rrp7 RRM-like N-terminal domain RRM_7 PF16367.5 EXF82638.1 - 0.0089 16.1 0.0 1.7 8.8 0.0 3.5 3 0 0 3 3 3 1 RNA recognition motif Mg_trans_NIPA PF05653.14 EXF82639.1 - 3.2e-62 210.3 8.0 1.9e-59 201.2 5.2 2.2 2 0 0 2 2 2 2 Magnesium transporter NIPA EamA PF00892.20 EXF82639.1 - 0.002 18.3 1.9 0.002 18.3 1.9 4.1 3 1 1 4 4 4 2 EamA-like transporter family SLC35F PF06027.12 EXF82639.1 - 0.025 14.1 3.0 1 8.8 0.0 2.3 2 0 0 2 2 2 0 Solute carrier family 35 DUF1461 PF07314.11 EXF82639.1 - 0.87 9.5 6.0 1.1 9.2 2.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1461) TssN PF17555.2 EXF82639.1 - 2.3 7.5 6.9 7.5 5.8 7.3 1.6 1 1 0 1 1 1 0 Type VI secretion system, TssN PBD PF00786.28 EXF82641.1 - 0.0037 17.6 0.7 0.04 14.3 0.2 2.5 2 0 0 2 2 2 1 P21-Rho-binding domain HLH PF00010.26 EXF82642.1 - 5.6e-12 45.4 0.0 1e-11 44.6 0.0 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain MerR-DNA-bind PF09278.11 EXF82642.1 - 0.95 10.0 4.5 3 8.5 4.5 1.8 1 0 0 1 1 1 0 MerR, DNA binding MFAP1 PF06991.11 EXF82642.1 - 5.8 6.7 13.0 0.05 13.5 4.7 1.7 2 0 0 2 2 2 0 Microfibril-associated/Pre-mRNA processing AMP-binding PF00501.28 EXF82643.1 - 3e-73 246.8 0.0 3.7e-73 246.5 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EXF82643.1 - 7.8e-20 71.6 0.1 1.7e-19 70.6 0.1 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Ins134_P3_kin_N PF17927.1 EXF82643.1 - 0.078 13.4 0.1 0.18 12.2 0.1 1.6 1 0 0 1 1 1 0 Inositol 1,3,4-trisphosphate 5/6-kinase pre-ATP-grasp domain Ifi-6-16 PF06140.13 EXF82643.1 - 0.089 12.7 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 Interferon-induced 6-16 family LysR_substrate PF03466.20 EXF82643.1 - 0.14 11.5 0.0 0.34 10.2 0.0 1.6 2 0 0 2 2 2 0 LysR substrate binding domain POB3_N PF17292.2 EXF82644.1 - 8.9e-31 106.2 0.3 2e-29 101.8 0.1 2.7 3 0 0 3 3 3 1 POB3-like N-terminal PH domain SSrecog PF03531.14 EXF82644.1 - 1.8e-30 104.6 0.7 7.7e-30 102.6 0.0 2.5 3 0 0 3 3 3 1 Structure-specific recognition protein (SSRP1) Rtt106 PF08512.12 EXF82644.1 - 1.1e-22 80.2 0.1 1.3e-21 76.8 0.0 2.6 3 0 0 3 3 3 1 Histone chaperone Rttp106-like PPP4R2 PF09184.11 EXF82644.1 - 5.3 6.6 15.0 8.2 5.9 15.0 1.3 1 0 0 1 1 1 0 PPP4R2 Aldo_ket_red PF00248.21 EXF82645.1 - 0.00039 19.7 0.0 0.00051 19.3 0.0 1.2 1 0 0 1 1 1 1 Aldo/keto reductase family zinc_ribbon_2 PF13240.6 EXF82646.1 - 0.049 13.4 0.4 0.11 12.3 0.4 1.5 1 0 0 1 1 1 0 zinc-ribbon domain Glyco_hydro_1 PF00232.18 EXF82647.1 - 1.8e-149 498.1 0.0 2.2e-149 497.8 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 1 Mannosyl_trans3 PF11051.8 EXF82648.1 - 0.012 15.0 0.0 0.018 14.4 0.0 1.2 1 0 0 1 1 1 0 Mannosyltransferase putative Glyco_transf_8 PF01501.20 EXF82648.1 - 0.029 13.9 0.7 0.36 10.3 0.0 2.1 2 0 0 2 2 2 0 Glycosyl transferase family 8 FXR_C1 PF16096.5 EXF82648.1 - 9.6 6.5 6.4 24 5.2 6.4 1.6 1 0 0 1 1 1 0 Fragile X-related 1 protein C-terminal region 2 SBF_like PF13593.6 EXF82650.1 - 6.6e-89 298.3 19.1 7.7e-89 298.1 19.1 1.0 1 0 0 1 1 1 1 SBF-like CPA transporter family (DUF4137) DUF4203 PF13886.6 EXF82651.1 - 2.6e-48 164.3 28.3 3.5e-48 163.9 28.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4203) Hist_rich_Ca-bd PF10529.9 EXF82651.1 - 5.3 7.4 7.4 30 5.0 7.4 2.4 1 0 0 1 1 1 0 Histidine-rich Calcium-binding repeat region DUF2070 PF09843.9 EXF82651.1 - 5.4 5.2 6.2 9.2 4.4 6.2 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Autophagy_N PF03986.13 EXF82653.1 - 5.5e-46 155.9 0.0 5.5e-46 155.9 0.0 2.5 3 0 0 3 3 3 1 Autophagocytosis associated protein (Atg3), N-terminal domain Autophagy_act_C PF03987.15 EXF82653.1 - 6.8e-16 58.6 0.1 1.6e-15 57.4 0.1 1.7 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain Autophagy_C PF10381.9 EXF82653.1 - 1.5e-15 56.4 0.6 2.5e-15 55.7 0.6 1.4 1 0 0 1 1 1 1 Autophagocytosis associated protein C-terminal zf-CCCH PF00642.24 EXF82653.1 - 1.6e-07 31.1 2.4 3.5e-07 30.0 2.4 1.6 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-C3HC4_3 PF13920.6 EXF82653.1 - 1e-06 28.5 5.2 1e-06 28.5 5.2 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EXF82653.1 - 3.3e-06 27.0 7.5 3.3e-06 27.0 7.5 1.7 2 0 0 2 2 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EXF82653.1 - 3.6e-06 26.9 6.7 3.6e-06 26.9 6.7 1.8 2 0 0 2 2 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EXF82653.1 - 3.6e-06 26.7 9.1 3.6e-06 26.7 9.1 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EXF82653.1 - 2.4e-05 24.1 8.0 2.4e-05 24.1 8.0 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf_CCCH_4 PF18345.1 EXF82653.1 - 6.9e-05 22.8 6.4 0.00014 21.8 6.4 1.6 1 0 0 1 1 1 1 Zinc finger domain zf-RING_10 PF16685.5 EXF82653.1 - 0.00015 21.8 2.2 0.00042 20.4 2.2 1.8 1 0 0 1 1 1 1 zinc RING finger of MSL2 zf-RING_2 PF13639.6 EXF82653.1 - 0.00025 21.3 6.9 0.00025 21.3 6.9 1.9 2 0 0 2 2 1 1 Ring finger domain zf-CCCH_4 PF18044.1 EXF82653.1 - 0.00096 18.9 2.6 0.00096 18.9 2.6 1.9 2 0 0 2 2 2 1 CCCH-type zinc finger Prok-RING_4 PF14447.6 EXF82653.1 - 0.0092 15.8 7.2 0.022 14.6 5.3 2.3 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 Harakiri PF15196.6 EXF82653.1 - 0.12 12.9 0.7 0.31 11.5 0.7 1.8 1 0 0 1 1 1 0 Activator of apoptosis harakiri zf-C3HC4_4 PF15227.6 EXF82653.1 - 0.12 12.5 8.1 0.29 11.3 8.1 1.7 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Mcp5_PH PF12814.7 EXF82654.1 - 5.1e-45 152.5 0.0 9.3e-45 151.7 0.0 1.4 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology PH PF00169.29 EXF82654.1 - 1.5e-05 25.4 0.0 3.8e-05 24.1 0.0 1.7 1 0 0 1 1 1 1 PH domain Dynein_IC2 PF11540.8 EXF82654.1 - 1 9.4 9.5 78 3.3 0.1 6.8 7 0 0 7 7 7 0 Cytoplasmic dynein 1 intermediate chain 2 DUF2205 PF10224.9 EXF82654.1 - 4.7 7.3 10.3 0.22 11.6 2.4 2.9 2 0 0 2 2 2 0 Short coiled-coil protein MMM1 PF10296.9 EXF82655.1 - 3.9e-06 26.1 0.0 3.9e-06 26.1 0.0 2.0 3 0 0 3 3 3 1 Maintenance of mitochondrial morphology protein 1 Edc3_linker PF16598.5 EXF82655.1 - 8.2 7.2 10.0 4.9 7.9 5.1 3.0 2 1 1 3 3 3 0 Linker region of enhancer of mRNA-decapping protein 3 DNA_pol_B PF00136.21 EXF82656.1 - 1.2e-104 350.7 0.0 1.7e-104 350.1 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 EXF82656.1 - 2e-22 79.8 0.0 1.8e-11 43.8 0.0 2.6 2 1 0 2 2 2 2 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.6 EXF82656.1 - 8e-17 61.5 6.3 8e-17 61.5 6.3 2.2 2 0 0 2 2 2 1 C4-type zinc-finger of DNA polymerase delta XkdW PF09636.10 EXF82656.1 - 0.031 14.3 0.2 0.086 12.9 0.2 1.7 1 0 0 1 1 1 0 XkdW protein Slu7 PF11708.8 EXF82657.1 - 8.5e-75 252.0 21.5 8.5e-75 252.0 21.5 2.6 3 1 0 3 3 3 1 Pre-mRNA splicing Prp18-interacting factor zf-CCHC_4 PF14392.6 EXF82657.1 - 0.028 14.1 0.5 0.052 13.3 0.5 1.4 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC PF00098.23 EXF82657.1 - 0.11 12.7 2.7 0.21 11.7 2.7 1.4 1 0 0 1 1 1 0 Zinc knuckle S4 PF01479.25 EXF82658.1 - 2.4e-12 46.4 0.9 2.4e-12 46.4 0.9 2.5 3 0 0 3 3 3 1 S4 domain Ribosomal_S4 PF00163.19 EXF82658.1 - 1e-05 26.4 0.1 1.8e-05 25.6 0.1 1.5 1 0 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain Ribosomal_L21e PF01157.18 EXF82659.1 - 2e-47 159.2 4.6 3.2e-47 158.5 4.6 1.3 1 0 0 1 1 1 1 Ribosomal protein L21e DUF5486 PF17588.2 EXF82659.1 - 0.011 15.6 1.8 0.15 12.0 0.1 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5486) ANTH PF07651.16 EXF82660.1 - 5.8e-82 274.8 0.0 5.8e-82 274.8 0.0 2.5 3 0 0 3 3 3 1 ANTH domain I_LWEQ PF01608.17 EXF82660.1 - 4.7e-55 186.0 9.7 4.7e-55 186.0 9.7 5.9 4 1 1 5 5 5 2 I/LWEQ domain TcdB_N PF12918.7 EXF82660.1 - 3.4 8.0 7.1 0.23 11.8 0.4 2.8 3 0 0 3 3 3 0 TcdB toxin N-terminal helical domain HMG_box PF00505.19 EXF82662.1 - 5.3e-22 78.0 1.3 8.6e-22 77.3 1.3 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EXF82662.1 - 3.6e-08 33.9 0.5 6.9e-08 33.0 0.5 1.4 1 0 0 1 1 1 1 HMG-box domain MATalpha_HMGbox PF04769.12 EXF82662.1 - 4.8e-05 22.8 0.0 6.6e-05 22.3 0.0 1.2 1 0 0 1 1 1 1 Mating-type protein MAT alpha 1 HMG-box NAAA-beta PF15508.6 EXF82662.1 - 0.11 12.8 0.7 2.2 8.6 0.1 2.8 3 0 0 3 3 3 0 beta subunit of N-acylethanolamine-hydrolyzing acid amidase TMEM171 PF15471.6 EXF82662.1 - 0.17 10.8 0.1 0.21 10.5 0.1 1.1 1 0 0 1 1 1 0 Transmembrane protein family 171 Exo_endo_phos PF03372.23 EXF82663.1 - 6.6e-09 35.6 0.0 1.3e-08 34.6 0.0 1.5 2 0 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 EXF82663.1 - 0.013 15.3 0.0 0.6 10.0 0.0 2.3 1 1 0 1 1 1 0 Endonuclease-reverse transcriptase zf-GRF PF06839.12 EXF82663.1 - 0.061 13.4 6.0 0.18 12.0 6.0 1.8 1 1 0 1 1 1 0 GRF zinc finger COX6A PF02046.15 EXF82664.1 - 5.3e-38 129.9 8.7 9.2e-33 113.1 4.2 2.2 2 0 0 2 2 2 2 Cytochrome c oxidase subunit VIa DUF2933 PF11666.8 EXF82664.1 - 0.16 12.1 0.1 0.27 11.3 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2933) CIA30 PF08547.12 EXF82665.1 - 1.3e-46 158.6 0.0 1.7e-46 158.2 0.0 1.2 1 0 0 1 1 1 1 Complex I intermediate-associated protein 30 (CIA30) HemolysinCabind PF00353.19 EXF82665.1 - 0.071 13.1 0.5 0.12 12.4 0.5 1.3 1 0 0 1 1 1 0 RTX calcium-binding nonapeptide repeat (4 copies) RRM_1 PF00076.22 EXF82666.1 - 1.1e-17 63.6 0.1 8.6e-09 35.1 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PHM7_cyt PF14703.6 EXF82666.1 - 1.6 9.0 0.0 1.6 9.0 0.0 4.1 3 1 0 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter TRI12 PF06609.13 EXF82667.1 - 4.8e-43 147.5 14.1 6.6e-43 147.0 14.1 1.0 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_1 PF07690.16 EXF82667.1 - 1.8e-24 86.3 37.3 2.9e-23 82.4 36.8 2.4 2 1 0 2 2 2 1 Major Facilitator Superfamily DUF4212 PF13937.6 EXF82667.1 - 9.4 6.7 7.9 6 7.3 0.5 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4212) Semialdhyde_dhC PF02774.18 EXF82668.1 - 4.9e-38 131.0 0.0 6.6e-38 130.6 0.0 1.2 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, dimerisation domain Semialdhyde_dh PF01118.24 EXF82668.1 - 1.2e-29 103.2 0.0 3.7e-29 101.6 0.0 1.8 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain GFO_IDH_MocA PF01408.22 EXF82668.1 - 0.0051 17.6 0.0 0.01 16.6 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold DapB_N PF01113.20 EXF82668.1 - 0.021 14.9 0.0 0.055 13.6 0.0 1.7 2 0 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus Sacchrp_dh_NADP PF03435.18 EXF82668.1 - 0.11 12.8 0.0 0.58 10.4 0.0 2.1 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain Gln_amidase PF15644.6 EXF82669.1 - 0.053 14.5 0.0 0.19 12.7 0.0 1.7 2 1 0 2 2 2 0 Papain fold toxin 1, glutamine deamidase Sec2p PF06428.11 EXF82671.1 - 2.3e-25 88.3 17.6 2.3e-25 88.3 17.6 2.7 2 0 0 2 2 2 1 GDP/GTP exchange factor Sec2p DUF3348 PF11828.8 EXF82671.1 - 0.77 9.4 16.6 0.12 12.0 8.1 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF3348) DUF5339 PF17274.2 EXF82671.1 - 2.6 9.0 10.7 4.6 8.2 0.5 2.9 2 0 0 2 2 2 0 Family of unknown function (DUF5339) PMT PF02366.18 EXF82672.1 - 1.4e-81 273.7 14.7 1.4e-81 273.7 14.7 1.9 2 1 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 EXF82672.1 - 1.2e-68 230.6 12.4 1.2e-68 230.6 12.4 2.5 3 0 0 3 3 3 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 EXF82672.1 - 1.9e-45 155.0 0.0 4.4e-45 153.8 0.0 1.6 1 1 0 1 1 1 1 MIR domain PRP21_like_P PF12230.8 EXF82673.1 - 5.6e-56 189.8 18.2 1.1e-54 185.7 18.2 2.1 1 1 0 1 1 1 1 Pre-mRNA splicing factor PRP21 like protein Surp PF01805.20 EXF82673.1 - 3.7e-40 135.7 4.7 1.2e-20 73.2 0.2 2.5 2 0 0 2 2 2 2 Surp module NinF PF05810.12 EXF82673.1 - 0.0055 16.6 0.1 0.015 15.1 0.1 1.7 1 0 0 1 1 1 1 NinF protein zf_UBZ PF18439.1 EXF82673.1 - 0.011 15.4 0.4 0.019 14.6 0.4 1.4 1 0 0 1 1 1 0 Ubiquitin-Binding Zinc Finger FAM70 PF14967.6 EXF82673.1 - 0.15 11.5 1.2 0.24 10.8 1.2 1.3 1 0 0 1 1 1 0 FAM70 protein PX PF00787.24 EXF82674.1 - 7.4e-25 87.1 0.0 8.5e-25 86.9 0.0 1.0 1 0 0 1 1 1 1 PX domain Ribophorin_I PF04597.14 EXF82675.1 - 1.1e-153 512.6 3.8 1.3e-153 512.4 3.8 1.0 1 0 0 1 1 1 1 Ribophorin I Hexokinase_2 PF03727.16 EXF82676.1 - 2.3e-83 279.3 0.0 4.1e-83 278.5 0.0 1.4 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 EXF82676.1 - 1.8e-73 246.7 0.0 6e-73 245.0 0.0 1.7 2 0 0 2 2 2 1 Hexokinase TPP_enzyme_N PF02776.18 EXF82676.1 - 0.095 12.3 0.0 0.18 11.4 0.0 1.4 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain FGGY_N PF00370.21 EXF82676.1 - 0.12 11.9 0.0 0.29 10.7 0.0 1.6 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, N-terminal domain Ank_2 PF12796.7 EXF82677.1 - 0.0095 16.5 0.0 0.32 11.6 0.0 2.3 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Paralemmin PF03285.15 EXF82677.1 - 0.58 9.7 5.4 1.1 8.7 5.4 1.4 1 0 0 1 1 1 0 Paralemmin VTC PF09359.10 EXF82678.1 - 2.6e-98 328.8 0.0 3.9e-98 328.2 0.0 1.3 1 0 0 1 1 1 1 VTC domain SPX PF03105.19 EXF82678.1 - 5e-14 53.0 6.2 3.7e-06 27.1 0.1 4.1 3 1 1 4 4 4 3 SPX domain DUF202 PF02656.15 EXF82678.1 - 1.1e-13 51.4 0.6 2.1e-13 50.5 0.6 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF202) EBV-NA3 PF05009.12 EXF82678.1 - 0.23 11.0 2.9 0.16 11.5 1.1 1.6 2 0 0 2 2 2 0 Epstein-Barr virus nuclear antigen 3 (EBNA-3) HSP20 PF00011.21 EXF82679.1 - 2e-10 40.7 0.0 2.8e-08 33.8 0.0 2.1 1 1 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 EXF82679.1 - 3.5e-05 23.3 0.2 0.0081 15.7 0.1 3.1 1 1 1 2 2 2 1 HSP20-like domain found in ArsA HasA PF06438.12 EXF82679.1 - 0.092 12.4 0.2 0.15 11.7 0.2 1.3 1 0 0 1 1 1 0 Heme-binding protein A (HasA) Indigoidine_A PF04227.12 EXF82680.1 - 7.5e-107 357.0 1.6 9.9e-107 356.6 1.6 1.2 1 0 0 1 1 1 1 Indigoidine synthase A like protein PfkB PF00294.24 EXF82680.1 - 0.00033 20.1 0.1 0.00053 19.4 0.1 1.4 1 0 0 1 1 1 1 pfkB family carbohydrate kinase WD40 PF00400.32 EXF82682.1 - 4.3e-06 27.3 0.0 1 10.3 0.0 5.0 5 1 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EXF82682.1 - 7.4e-05 23.0 0.0 0.14 12.5 0.0 4.6 4 2 2 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 EXF82682.1 - 0.057 13.4 0.5 0.91 9.5 0.0 2.6 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat Sod_Ni PF09055.11 EXF82683.1 - 0.1 13.2 0.1 0.1 13.2 0.1 1.9 2 1 0 2 2 2 0 Nickel-containing superoxide dismutase COG4 PF08318.12 EXF82685.1 - 3.3e-124 414.4 0.0 4.7e-124 413.8 0.0 1.2 1 0 0 1 1 1 1 COG4 transport protein TetR_C_12 PF16914.5 EXF82685.1 - 0.0044 17.1 0.6 0.059 13.5 0.2 2.9 2 1 0 2 2 2 1 Bacterial transcriptional repressor C-terminal HSCB_C PF07743.13 EXF82685.1 - 0.039 14.5 4.1 0.27 11.7 0.2 3.5 3 0 0 3 3 3 0 HSCB C-terminal oligomerisation domain Autophagy_C PF10381.9 EXF82685.1 - 3.7 7.1 6.5 16 5.1 1.5 2.4 2 0 0 2 2 2 0 Autophagocytosis associated protein C-terminal E1-E2_ATPase PF00122.20 EXF82686.1 - 2.6e-44 150.9 0.1 2.6e-44 150.9 0.1 1.8 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 EXF82686.1 - 1.7e-42 145.2 1.4 3.5e-42 144.2 1.4 1.6 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 EXF82686.1 - 2.3e-20 73.8 0.1 1.8e-19 70.8 0.1 2.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EXF82686.1 - 9.1e-20 70.1 0.0 1.8e-19 69.2 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 EXF82686.1 - 5.4e-12 45.6 0.0 1.7e-11 44.0 0.0 1.9 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EXF82686.1 - 0.00056 19.7 0.3 0.00099 18.9 0.3 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 EXF82686.1 - 0.012 16.0 0.0 0.029 14.8 0.0 1.7 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Rad21_Rec8_N PF04825.13 EXF82687.1 - 3.9e-37 126.8 0.0 7.2e-37 125.9 0.0 1.4 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein Rad21_Rec8 PF04824.16 EXF82687.1 - 6.1e-09 35.0 0.0 1.1e-08 34.2 0.0 1.5 1 0 0 1 1 1 1 Conserved region of Rad21 / Rec8 like protein EXS PF03124.14 EXF82688.1 - 4e-113 378.1 9.8 4.6e-113 377.9 9.8 1.0 1 0 0 1 1 1 1 EXS family Glyco_transf_15 PF01793.16 EXF82689.1 - 7.4e-71 239.0 5.0 1.6e-70 238.0 5.0 1.4 1 1 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase DUF5594 PF18057.1 EXF82689.1 - 0.016 15.1 0.0 0.051 13.4 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF5594) NUDIX PF00293.28 EXF82691.1 - 7.7e-09 35.7 0.0 2.4e-08 34.1 0.0 1.9 1 0 0 1 1 1 1 NUDIX domain FDC-SP PF15215.6 EXF82691.1 - 0.072 13.6 0.1 0.16 12.6 0.1 1.6 1 0 0 1 1 1 0 Follicular dendritic cell secreted peptide Ctr PF04145.15 EXF82692.1 - 2.6e-25 89.8 1.6 4.4e-25 89.0 1.6 1.4 1 1 0 1 1 1 1 Ctr copper transporter family EpuA PF11772.8 EXF82692.1 - 0.18 11.5 0.2 0.18 11.5 0.2 2.8 3 0 0 3 3 3 0 DNA-directed RNA polymerase subunit beta 3-HAO PF06052.12 EXF82693.1 - 4.7e-64 214.6 0.0 5.5e-64 214.4 0.0 1.1 1 0 0 1 1 1 1 3-hydroxyanthranilic acid dioxygenase Cupin_2 PF07883.11 EXF82693.1 - 5.1e-06 26.1 0.0 7.6e-06 25.5 0.0 1.2 1 0 0 1 1 1 1 Cupin domain Cupin_1 PF00190.22 EXF82693.1 - 0.00018 21.2 0.1 0.00026 20.6 0.1 1.2 1 0 0 1 1 1 1 Cupin AraC_binding PF02311.19 EXF82693.1 - 0.0055 16.6 0.0 0.0089 15.9 0.0 1.2 1 0 0 1 1 1 1 AraC-like ligand binding domain RecQ_Zn_bind PF16124.5 EXF82693.1 - 0.02 15.6 0.4 0.032 14.9 0.4 1.3 1 0 0 1 1 1 0 RecQ zinc-binding DZR PF12773.7 EXF82693.1 - 0.055 13.5 1.3 0.16 12.0 1.3 1.8 1 1 0 1 1 1 0 Double zinc ribbon FAA_hydrolase PF01557.18 EXF82694.1 - 4.1e-51 173.7 0.0 4.8e-51 173.5 0.0 1.0 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family RCR PF12273.8 EXF82696.1 - 1.3e-21 77.4 21.4 3e-21 76.3 21.4 1.6 1 1 0 1 1 1 1 Chitin synthesis regulation, resistance to Congo red Adeno_E3_CR2 PF02439.15 EXF82696.1 - 0.1 12.4 0.5 0.18 11.6 0.5 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 SKG6 PF08693.10 EXF82696.1 - 0.14 11.6 2.4 0.22 11.0 2.4 1.3 1 0 0 1 1 1 0 Transmembrane alpha-helix domain DUF4381 PF14316.6 EXF82696.1 - 0.17 12.1 1.3 0.29 11.3 1.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) EphA2_TM PF14575.6 EXF82696.1 - 0.21 12.5 0.1 0.35 11.8 0.1 1.5 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain LRRNT_2 PF08263.12 EXF82697.1 - 2.2 8.7 4.5 0.68 10.3 1.2 1.8 2 0 0 2 2 2 0 Leucine rich repeat N-terminal domain Methyltransf_23 PF13489.6 EXF82698.1 - 2.1e-16 60.2 0.0 5.8e-16 58.8 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF82698.1 - 7.2e-10 39.5 0.0 1.6e-09 38.3 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF82698.1 - 5.3e-07 30.3 0.0 2.7e-06 28.0 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF82698.1 - 1.4e-06 28.9 0.0 2.9e-06 27.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF82698.1 - 1.6e-06 28.0 0.0 2e-05 24.4 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 EXF82698.1 - 0.025 14.1 0.0 0.055 12.9 0.0 1.5 1 0 0 1 1 1 0 Putative methyltransferase MTS PF05175.14 EXF82698.1 - 0.06 12.9 0.0 0.1 12.2 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_23 PF13489.6 EXF82699.1 - 1.1e-18 67.6 0.0 1.6e-18 67.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF82699.1 - 4.2e-09 37.0 0.0 9.1e-09 35.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF82699.1 - 1.8e-08 34.3 0.0 7.1e-08 32.4 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF82699.1 - 6.9e-07 29.9 0.0 3.2e-06 27.8 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF82699.1 - 1.6e-06 28.7 0.0 3.3e-06 27.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 EXF82699.1 - 0.0016 17.9 0.0 0.0033 16.9 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase Ubie_methyltran PF01209.18 EXF82699.1 - 0.035 13.4 0.0 0.87 8.9 0.0 2.1 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family Methyltransf_2 PF00891.18 EXF82699.1 - 0.13 11.6 0.0 0.39 10.0 0.0 1.7 2 0 0 2 2 2 0 O-methyltransferase domain Chitin_synth_1 PF01644.17 EXF82700.1 - 2e-74 249.0 0.2 3.1e-74 248.4 0.2 1.3 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.11 EXF82700.1 - 3.1e-28 97.5 0.0 6.4e-28 96.5 0.0 1.5 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.15 EXF82700.1 - 1.6e-21 76.5 3.7 2.4e-16 59.5 0.0 2.5 3 0 0 3 3 3 2 Chitin synthase Glyco_trans_2_3 PF13632.6 EXF82700.1 - 0.00037 20.5 8.8 0.00037 20.5 8.8 2.5 2 1 0 2 2 2 1 Glycosyl transferase family group 2 PC4 PF02229.16 EXF82701.1 - 8.6e-24 82.9 0.4 1.4e-23 82.2 0.1 1.5 2 0 0 2 2 2 1 Transcriptional Coactivator p15 (PC4) YqfQ PF14181.6 EXF82701.1 - 0.079 13.2 0.3 0.079 13.2 0.3 2.0 2 0 0 2 2 2 0 YqfQ-like protein PXA PF02194.15 EXF82702.1 - 9.3e-34 117.0 0.4 2.6e-33 115.5 0.1 1.9 2 0 0 2 2 2 1 PXA domain Nexin_C PF08628.12 EXF82702.1 - 2.8e-24 85.8 0.1 9.6e-24 84.1 0.1 2.0 1 0 0 1 1 1 1 Sorting nexin C terminal PX PF00787.24 EXF82702.1 - 7.3e-07 29.2 0.1 4.7e-06 26.6 0.0 2.3 2 0 0 2 2 2 1 PX domain FliJ PF02050.16 EXF82702.1 - 0.02 15.1 1.4 0.044 14.0 1.4 1.5 1 0 0 1 1 1 0 Flagellar FliJ protein Macoilin PF09726.9 EXF82702.1 - 0.11 11.1 10.6 0.17 10.4 10.6 1.2 1 0 0 1 1 1 0 Macoilin family Hydantoinase_B PF02538.14 EXF82703.1 - 2.9e-220 732.0 0.1 4.1e-220 731.6 0.1 1.2 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Hydantoinase_A PF01968.18 EXF82703.1 - 7.2e-104 347.1 1.0 1.4e-103 346.2 1.0 1.5 1 0 0 1 1 1 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.13 EXF82703.1 - 3.2e-62 209.4 2.1 1.1e-60 204.4 0.1 2.6 2 0 0 2 2 2 2 Hydantoinase/oxoprolinase N-terminal region Ran_BP1 PF00638.18 EXF82706.1 - 4.5e-12 46.3 0.0 2.8e-11 43.7 0.0 2.2 1 1 0 1 1 1 1 RanBP1 domain Nucleoporin_FG PF13634.6 EXF82706.1 - 0.00096 20.0 18.9 0.00096 20.0 18.9 10.1 2 1 6 9 9 9 6 Nucleoporin FG repeat region SCP2 PF02036.17 EXF82707.1 - 1.5e-25 89.6 0.3 1.7e-25 89.4 0.3 1.1 1 0 0 1 1 1 1 SCP-2 sterol transfer family Alkyl_sulf_C PF14864.6 EXF82707.1 - 3.3e-06 27.4 0.1 3.8e-06 27.2 0.1 1.1 1 0 0 1 1 1 1 Alkyl sulfatase C-terminal SCP2_2 PF13530.6 EXF82707.1 - 0.024 15.0 0.0 0.029 14.8 0.0 1.2 1 0 0 1 1 1 0 Sterol carrier protein domain Pectate_lyase_3 PF12708.7 EXF82709.1 - 5.6e-36 124.4 23.5 8e-27 94.5 0.4 4.4 3 2 1 4 4 4 3 Pectate lyase superfamily protein Pentapeptide PF00805.22 EXF82709.1 - 2.3 7.9 4.7 27 4.5 0.0 4.2 5 0 0 5 5 5 0 Pentapeptide repeats (8 copies) LETM1 PF07766.13 EXF82710.1 - 2.1e-08 33.9 0.2 5.3e-08 32.5 0.1 1.6 2 0 0 2 2 2 1 LETM1-like protein DLH PF01738.18 EXF82711.1 - 1.5e-15 57.4 0.0 2.3e-13 50.2 0.0 2.2 2 0 0 2 2 2 2 Dienelactone hydrolase family Abhydrolase_3 PF07859.13 EXF82711.1 - 0.0053 16.6 0.4 0.087 12.7 0.0 2.6 1 1 2 3 3 3 1 alpha/beta hydrolase fold BAAT_C PF08840.11 EXF82711.1 - 0.0061 16.5 0.0 0.67 9.8 0.0 2.2 2 0 0 2 2 2 2 BAAT / Acyl-CoA thioester hydrolase C terminal GAF_2 PF13185.6 EXF82712.1 - 1.2e-09 38.5 0.0 1.9e-09 37.9 0.0 1.5 1 1 0 1 1 1 1 GAF domain GAF PF01590.26 EXF82712.1 - 6.3e-05 23.6 0.0 8.2e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 GAF domain Spermine_synth PF01564.17 EXF82714.1 - 8.7e-72 240.5 0.0 1.4e-71 239.8 0.0 1.3 1 0 0 1 1 1 1 Spermine/spermidine synthase domain Spermine_synt_N PF17284.2 EXF82714.1 - 1.9e-20 72.5 0.1 3.4e-20 71.7 0.1 1.4 1 0 0 1 1 1 1 Spermidine synthase tetramerisation domain Methyltransf_25 PF13649.6 EXF82714.1 - 0.00023 21.8 0.0 0.00063 20.4 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF82714.1 - 0.0046 17.7 0.2 0.033 14.9 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain DUF43 PF01861.16 EXF82714.1 - 0.012 14.8 0.0 0.017 14.3 0.0 1.3 1 0 0 1 1 1 0 Branched-chain polyamine synthase A C-terminal domain Methyltransf_23 PF13489.6 EXF82714.1 - 0.032 14.1 0.0 0.35 10.7 0.0 2.3 2 1 0 2 2 2 0 Methyltransferase domain CMAS PF02353.20 EXF82714.1 - 0.032 13.5 0.1 0.066 12.5 0.1 1.7 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_18 PF12847.7 EXF82714.1 - 0.048 13.6 0.0 0.089 12.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain G-alpha PF00503.20 EXF82715.1 - 1.2e-24 87.2 0.1 1.4e-24 86.9 0.1 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EXF82715.1 - 0.0014 18.1 0.0 0.0016 17.9 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family AAA_29 PF13555.6 EXF82715.1 - 0.024 14.4 0.0 0.036 13.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_25 PF13481.6 EXF82715.1 - 0.025 14.2 0.0 0.025 14.2 0.0 1.2 1 0 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.18 EXF82715.1 - 0.036 13.4 0.0 0.047 13.0 0.0 1.2 1 0 0 1 1 1 0 FtsK/SpoIIIE family DAP3 PF10236.9 EXF82715.1 - 0.057 12.6 0.1 0.067 12.3 0.1 1.1 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 DUF2999 PF11212.8 EXF82715.1 - 0.12 12.6 0.0 0.16 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2999) G-alpha PF00503.20 EXF82716.1 - 2.5e-82 276.9 0.0 2.9e-82 276.7 0.0 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EXF82716.1 - 6.2e-09 35.6 0.1 1.3e-08 34.5 0.1 1.5 1 1 0 1 1 1 1 ADP-ribosylation factor family CN_hydrolase PF00795.22 EXF82717.1 - 2.5e-54 184.4 0.0 2.8e-54 184.2 0.0 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase FAD_binding_4 PF01565.23 EXF82718.1 - 1.3e-22 80.0 0.6 1.3e-22 80.0 0.6 1.8 2 0 0 2 2 2 1 FAD binding domain BBE PF08031.12 EXF82718.1 - 2.1e-09 37.3 0.0 4.9e-09 36.1 0.0 1.7 1 0 0 1 1 1 1 Berberine and berberine like BTB PF00651.31 EXF82718.1 - 0.0014 18.8 0.0 0.0029 17.8 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain Pup_ligase PF03136.15 EXF82718.1 - 0.14 11.1 0.0 0.24 10.4 0.0 1.2 1 0 0 1 1 1 0 Pup-ligase protein p450 PF00067.22 EXF82719.1 - 1.3e-41 142.9 0.0 2.5e-41 141.9 0.0 1.5 1 1 0 1 1 1 1 Cytochrome P450 Thioesterase PF00975.20 EXF82720.1 - 6.5e-24 85.3 0.1 2.2e-23 83.6 0.0 1.9 2 1 0 2 2 2 1 Thioesterase domain Abhydrolase_6 PF12697.7 EXF82720.1 - 8.5e-07 29.8 0.0 1e-06 29.5 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EXF82720.1 - 1.2e-05 25.0 0.0 5.7e-05 22.9 0.0 2.0 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EXF82720.1 - 8.9e-05 21.9 0.0 0.00015 21.2 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 DUF2974 PF11187.8 EXF82720.1 - 0.00022 20.9 0.0 0.00034 20.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2974) Abhydrolase_3 PF07859.13 EXF82720.1 - 0.0057 16.5 0.0 0.0093 15.8 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.7 EXF82720.1 - 0.026 14.3 0.0 0.045 13.5 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family Abhydrolase_2 PF02230.16 EXF82720.1 - 0.088 12.6 0.0 0.42 10.4 0.0 1.9 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase PGAP1 PF07819.13 EXF82720.1 - 0.14 11.8 0.0 0.2 11.3 0.0 1.2 1 0 0 1 1 1 0 PGAP1-like protein Asp PF00026.23 EXF82721.1 - 4.3e-09 36.2 0.0 3.9e-08 33.1 0.0 2.2 1 1 0 1 1 1 1 Eukaryotic aspartyl protease FAD_binding_3 PF01494.19 EXF82722.1 - 1.6e-32 113.1 0.0 3.7e-32 112.0 0.0 1.5 1 1 0 1 1 1 1 FAD binding domain Trp_halogenase PF04820.14 EXF82722.1 - 2e-05 23.7 2.8 0.032 13.1 0.4 2.3 1 1 0 2 2 2 2 Tryptophan halogenase NAD_binding_8 PF13450.6 EXF82722.1 - 4.4e-05 23.6 1.0 0.0001 22.4 0.4 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 EXF82722.1 - 7e-05 22.0 0.7 0.00019 20.6 0.7 1.6 1 1 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_2 PF07992.14 EXF82722.1 - 0.00024 20.5 1.0 0.22 10.7 0.1 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EXF82722.1 - 0.0025 18.3 0.5 0.024 15.2 0.2 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EXF82722.1 - 0.0043 16.3 0.1 0.034 13.4 0.1 2.2 2 0 0 2 2 2 1 Thi4 family GCM PF03615.15 EXF82722.1 - 0.028 14.3 0.0 0.047 13.6 0.0 1.3 1 0 0 1 1 1 0 GCM motif protein DAO PF01266.24 EXF82722.1 - 0.065 12.8 4.0 0.81 9.2 1.3 2.2 1 1 0 2 2 2 0 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EXF82722.1 - 0.08 12.0 0.8 0.15 11.1 0.8 1.4 1 0 0 1 1 1 0 FAD binding domain K_oxygenase PF13434.6 EXF82722.1 - 0.16 11.1 0.0 3.7 6.6 0.0 2.1 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 EXF82722.1 - 0.72 9.8 2.0 16 5.5 0.1 2.3 2 0 0 2 2 2 0 FAD-NAD(P)-binding Zn_clus PF00172.18 EXF82723.1 - 1.3e-05 25.2 11.7 2.1e-05 24.5 11.7 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain KAR9 PF08580.10 EXF82723.1 - 7.9 4.9 10.7 4.1 5.8 8.0 1.8 2 0 0 2 2 2 0 Yeast cortical protein KAR9 NCBP3 PF10309.9 EXF82725.1 - 3.5e-22 78.0 0.0 6e-22 77.3 0.0 1.4 1 0 0 1 1 1 1 Nuclear cap-binding protein subunit 3 Apolipoprotein PF01442.18 EXF82725.1 - 0.013 15.4 11.9 0.03 14.2 11.9 1.5 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain Stathmin PF00836.19 EXF82725.1 - 0.031 14.2 1.4 0.077 13.0 1.4 1.7 1 0 0 1 1 1 0 Stathmin family HemX PF04375.14 EXF82725.1 - 0.041 13.2 4.1 0.081 12.2 4.1 1.5 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase MAD PF05557.13 EXF82725.1 - 0.048 12.0 12.4 0.11 10.9 12.3 1.5 1 1 0 1 1 1 0 Mitotic checkpoint protein Exonuc_VII_L PF02601.15 EXF82725.1 - 0.049 13.2 4.7 0.1 12.1 4.7 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF773 PF05600.12 EXF82725.1 - 0.1 11.3 5.8 0.16 10.7 5.8 1.2 1 0 0 1 1 1 0 CDK5 regulatory subunit-associated protein 3 MCPsignal PF00015.21 EXF82725.1 - 0.1 12.4 0.8 0.25 11.1 0.8 1.6 1 0 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Gp58 PF07902.11 EXF82725.1 - 0.14 10.4 4.5 0.22 9.8 4.5 1.2 1 0 0 1 1 1 0 gp58-like protein NleF_casp_inhib PF16809.5 EXF82725.1 - 0.15 12.0 1.2 0.6 10.0 0.1 2.2 1 1 1 2 2 2 0 NleF caspase inhibitor IFT57 PF10498.9 EXF82725.1 - 0.15 11.0 6.2 0.29 10.1 6.2 1.4 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Sec34 PF04136.15 EXF82725.1 - 0.18 11.7 1.0 0.42 10.5 1.0 1.6 1 0 0 1 1 1 0 Sec34-like family AAA_13 PF13166.6 EXF82725.1 - 0.22 10.1 2.2 0.32 9.6 2.2 1.1 1 0 0 1 1 1 0 AAA domain TSC22 PF01166.18 EXF82725.1 - 0.25 11.7 5.0 0.78 10.1 0.5 3.1 3 0 0 3 3 2 0 TSC-22/dip/bun family FPP PF05911.11 EXF82725.1 - 0.29 9.3 8.3 0.42 8.7 8.3 1.1 1 0 0 1 1 1 0 Filament-like plant protein, long coiled-coil APC_N_CC PF16689.5 EXF82725.1 - 0.31 11.1 2.2 0.87 9.7 2.2 1.7 1 0 0 1 1 1 0 Coiled-coil N-terminus of APC, dimerisation domain Spectrin PF00435.21 EXF82725.1 - 0.68 10.4 11.3 1.4 9.5 3.7 2.6 1 1 1 2 2 2 0 Spectrin repeat DUF16 PF01519.16 EXF82725.1 - 0.95 10.0 8.9 15 6.1 8.9 2.5 1 1 0 1 1 1 0 Protein of unknown function DUF16 YkyA PF10368.9 EXF82725.1 - 0.95 9.1 7.7 1.3 8.7 5.7 2.1 2 1 0 2 2 1 0 Putative cell-wall binding lipoprotein BLOC1_2 PF10046.9 EXF82725.1 - 1.3 9.4 6.3 4.8 7.5 0.1 3.1 1 1 2 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 SKA1 PF07160.12 EXF82725.1 - 1.3 8.8 7.7 0.39 10.5 3.0 2.1 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 1 Laminin_II PF06009.12 EXF82725.1 - 1.5 8.8 6.7 3.8 7.5 1.9 2.4 1 1 1 2 2 2 0 Laminin Domain II Nup54 PF13874.6 EXF82725.1 - 2.2 8.4 9.4 1.2 9.2 2.1 2.7 3 0 0 3 3 2 0 Nucleoporin complex subunit 54 SlyX PF04102.12 EXF82725.1 - 2.3 8.9 8.7 8 7.2 0.7 3.4 3 0 0 3 3 3 0 SlyX Seryl_tRNA_N PF02403.22 EXF82725.1 - 2.4 8.4 7.1 16 5.8 1.2 3.0 1 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain LXG PF04740.12 EXF82725.1 - 3 7.5 5.9 0.99 9.1 2.4 2.0 2 0 0 2 2 2 0 LXG domain of WXG superfamily Occludin_ELL PF07303.13 EXF82725.1 - 4.6 8.0 6.1 12 6.7 1.0 3.2 2 1 2 4 4 3 0 Occludin homology domain V-SNARE_C PF12352.8 EXF82725.1 - 4.7 7.6 7.4 8.4 6.8 1.7 3.3 2 1 1 3 3 3 0 Snare region anchored in the vesicle membrane C-terminus DUF1664 PF07889.12 EXF82725.1 - 4.7 7.3 6.6 57 3.8 6.6 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) Sugarporin_N PF11471.8 EXF82725.1 - 6.1 6.9 8.3 0.79 9.7 0.2 2.7 2 0 0 2 2 2 0 Maltoporin periplasmic N-terminal extension MscS_porin PF12795.7 EXF82725.1 - 7.1 6.1 14.7 1.8 8.0 2.6 2.6 2 0 0 2 2 2 0 Mechanosensitive ion channel porin domain CENP-F_leu_zip PF10473.9 EXF82725.1 - 7.3 6.6 16.5 1.2e+03 -0.6 3.4 2.3 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Nup88 PF10168.9 EXF82725.1 - 7.5 4.2 7.2 11 3.7 7.2 1.1 1 0 0 1 1 1 0 Nuclear pore component DUF4795 PF16043.5 EXF82725.1 - 8 6.0 8.8 26 4.3 8.8 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) Jnk-SapK_ap_N PF09744.9 EXF82725.1 - 8.9 6.5 13.2 6.3 7.0 10.8 1.9 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 CLZ PF16526.5 EXF82725.1 - 9.4 6.7 9.2 22 5.5 0.4 3.6 2 1 1 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Myb_DNA-binding PF00249.31 EXF82727.1 - 2.2e-23 82.2 1.0 2.7e-13 49.9 0.0 2.2 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EXF82727.1 - 3.8e-16 59.1 1.5 4.1e-13 49.4 0.0 2.2 1 1 1 2 2 2 2 Myb-like DNA-binding domain DUF2774 PF11242.8 EXF82727.1 - 0.017 15.3 0.0 0.14 12.3 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2774) HTH_23 PF13384.6 EXF82727.1 - 0.14 12.0 0.4 0.58 10.0 0.2 2.0 2 0 0 2 2 2 0 Homeodomain-like domain SWIRM PF04433.17 EXF82728.1 - 1.4e-13 51.0 0.0 2.7e-13 50.0 0.0 1.5 1 0 0 1 1 1 1 SWIRM domain AAA_12 PF13087.6 EXF82729.1 - 5.2e-34 117.6 0.0 8.3e-34 116.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 EXF82729.1 - 3.9e-21 76.0 1.1 1.7e-12 47.7 0.1 2.3 2 0 0 2 2 2 2 AAA domain AAA_30 PF13604.6 EXF82729.1 - 2.1e-09 37.4 0.1 1.4e-06 28.2 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.6 EXF82729.1 - 1.8e-07 31.6 0.0 2e-06 28.2 0.0 2.5 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EXF82729.1 - 4.3e-06 27.2 0.1 0.33 11.3 0.0 3.3 3 0 0 3 3 3 2 AAA ATPase domain PhoH PF02562.16 EXF82729.1 - 0.0025 17.3 0.1 0.0048 16.4 0.1 1.4 1 0 0 1 1 1 1 PhoH-like protein AAA_22 PF13401.6 EXF82729.1 - 0.0079 16.5 0.0 2.3 8.5 0.0 3.3 3 0 0 3 3 3 1 AAA domain T2SSE PF00437.20 EXF82729.1 - 0.036 13.1 0.2 0.089 11.8 0.0 1.6 2 0 0 2 2 2 0 Type II/IV secretion system protein IstB_IS21 PF01695.17 EXF82729.1 - 0.046 13.4 0.0 0.1 12.3 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_5 PF07728.14 EXF82729.1 - 0.059 13.4 0.0 0.31 11.0 0.0 2.1 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) ATPase PF06745.13 EXF82729.1 - 0.071 12.4 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 KaiC AAA_33 PF13671.6 EXF82729.1 - 0.078 13.1 0.3 0.45 10.7 0.1 2.4 2 0 0 2 2 2 0 AAA domain Helicase_RecD PF05127.14 EXF82729.1 - 0.087 12.7 0.1 0.55 10.1 0.0 2.1 2 0 0 2 2 2 0 Helicase AAA PF00004.29 EXF82729.1 - 0.11 13.0 2.1 8 6.9 1.0 3.2 2 1 1 3 3 3 0 ATPase family associated with various cellular activities (AAA) ResIII PF04851.15 EXF82729.1 - 0.14 12.2 0.0 0.26 11.3 0.0 1.4 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit DUF2075 PF09848.9 EXF82729.1 - 0.23 10.7 0.0 0.38 10.0 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) WD40 PF00400.32 EXF82730.1 - 1.2e-11 44.9 3.1 0.26 12.2 0.0 6.6 5 1 1 6 6 6 5 WD domain, G-beta repeat Drf_FH1 PF06346.12 EXF82730.1 - 2.1 8.1 24.3 6.5 6.5 1.5 2.7 2 0 0 2 2 2 0 Formin Homology Region 1 Sugar_tr PF00083.24 EXF82731.1 - 4.6e-83 279.6 19.0 5.2e-83 279.4 19.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF82731.1 - 7.6e-13 48.1 34.9 7.6e-13 48.1 34.9 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2574 PF10836.8 EXF82731.1 - 0.11 12.4 0.1 1.7 8.6 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2574) Romo1 PF10247.9 EXF82731.1 - 8.5 6.8 7.5 3.9 7.9 0.4 3.7 3 0 0 3 3 3 0 Reactive mitochondrial oxygen species modulator 1 F_actin_cap_B PF01115.17 EXF82732.1 - 9.7e-104 346.2 0.0 1.1e-103 346.0 0.0 1.0 1 0 0 1 1 1 1 F-actin capping protein, beta subunit BAH PF01426.18 EXF82733.1 - 0.00067 19.5 0.2 0.0023 17.8 0.1 1.9 1 1 1 2 2 2 1 BAH domain PHD PF00628.29 EXF82733.1 - 0.0036 17.2 2.9 0.0097 15.8 2.9 1.7 1 0 0 1 1 1 1 PHD-finger zf-HC5HC2H PF13771.6 EXF82733.1 - 0.011 15.9 1.9 0.027 14.7 1.9 1.6 1 0 0 1 1 1 0 PHD-like zinc-binding domain VEGF_C PF14554.6 EXF82733.1 - 0.012 15.7 1.4 0.03 14.4 1.4 1.7 1 0 0 1 1 1 0 VEGF heparin-binding domain Lipoprotein_20 PF13942.6 EXF82733.1 - 0.028 14.3 0.5 0.65 9.9 0.1 2.2 2 0 0 2 2 2 0 YfhG lipoprotein FANCL_C PF11793.8 EXF82733.1 - 0.035 14.3 1.7 0.035 14.3 1.7 1.8 2 0 0 2 2 2 0 FANCL C-terminal domain ATG22 PF11700.8 EXF82734.1 - 1e-199 664.1 9.0 1.2e-199 663.9 9.0 1.0 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like MFS_2 PF13347.6 EXF82734.1 - 4.8e-07 28.7 16.7 6.6e-06 24.9 2.9 2.3 2 0 0 2 2 2 2 MFS/sugar transport protein MFS_1 PF07690.16 EXF82734.1 - 5.2e-07 28.9 41.3 0.0015 17.6 4.8 3.2 2 1 1 3 3 3 3 Major Facilitator Superfamily DUF3602 PF12223.8 EXF82735.1 - 3.3e-23 82.1 18.3 3.4e-22 78.8 4.9 2.8 2 1 1 3 3 3 2 Protein of unknown function (DUF3602) Ank_2 PF12796.7 EXF82736.1 - 6.4e-58 193.3 0.4 2e-12 47.5 0.0 6.6 3 2 2 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EXF82736.1 - 3e-50 168.0 3.4 3e-08 34.1 0.1 10.7 4 2 7 11 11 11 10 Ankyrin repeats (many copies) Ank PF00023.30 EXF82736.1 - 2.1e-45 151.3 9.7 0.00031 21.0 0.0 12.1 11 1 1 12 12 12 9 Ankyrin repeat Ank_5 PF13857.6 EXF82736.1 - 5.7e-44 147.6 6.1 4.1e-07 30.2 0.1 8.6 5 2 4 9 9 9 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EXF82736.1 - 3.3e-41 134.6 9.9 9.2e-05 22.6 0.0 11.9 12 1 0 12 12 12 7 Ankyrin repeat DUF4635 PF15466.6 EXF82736.1 - 0.0031 17.0 0.5 0.0073 15.8 0.5 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4635) Aldedh PF00171.22 EXF82736.1 - 0.038 12.5 0.0 0.062 11.8 0.0 1.2 1 0 0 1 1 1 0 Aldehyde dehydrogenase family Syntaxin-6_N PF09177.11 EXF82736.1 - 0.1 13.2 1.7 0.16 12.5 0.6 2.0 2 0 0 2 2 2 0 Syntaxin 6, N-terminal End3 PF12761.7 EXF82736.1 - 0.16 12.1 5.2 0.36 11.0 5.2 1.6 1 0 0 1 1 1 0 Actin cytoskeleton-regulatory complex protein END3 TSC22 PF01166.18 EXF82736.1 - 0.17 12.2 0.4 24 5.3 0.0 2.9 2 0 0 2 2 2 0 TSC-22/dip/bun family DRMBL PF07522.14 EXF82738.1 - 1e-34 119.0 0.0 2e-34 118.1 0.0 1.5 1 0 0 1 1 1 1 DNA repair metallo-beta-lactamase Lactamase_B_2 PF12706.7 EXF82738.1 - 3e-06 26.9 0.0 6.5e-06 25.8 0.0 1.5 1 0 0 1 1 1 1 Beta-lactamase superfamily domain LSM PF01423.22 EXF82739.1 - 2e-17 62.6 0.5 2.5e-17 62.3 0.5 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EXF82739.1 - 0.0027 17.8 0.0 0.0033 17.5 0.0 1.2 1 0 0 1 1 1 1 Ataxin 2 SM domain Hfq PF17209.3 EXF82739.1 - 0.01 15.5 0.0 0.014 15.0 0.0 1.3 1 0 0 1 1 1 0 Hfq protein DUF150_C PF17384.2 EXF82739.1 - 0.074 13.2 0.1 0.11 12.7 0.1 1.3 1 0 0 1 1 1 0 RimP C-terminal SH3 domain OGG_N PF07934.12 EXF82740.1 - 1.8e-35 121.7 0.0 3.1e-35 120.9 0.0 1.4 1 0 0 1 1 1 1 8-oxoguanine DNA glycosylase, N-terminal domain HhH-GPD PF00730.25 EXF82740.1 - 2.2e-17 63.5 0.0 3.7e-17 62.7 0.0 1.4 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 EXF82740.1 - 0.00018 21.2 0.0 0.00059 19.6 0.0 1.9 1 0 0 1 1 1 1 Helix-hairpin-helix motif SF3b1 PF08920.10 EXF82741.1 - 5.8e-28 97.8 7.3 5.8e-28 97.8 7.3 2.4 1 1 1 2 2 2 1 Splicing factor 3B subunit 1 HEAT_EZ PF13513.6 EXF82741.1 - 4.6e-12 46.2 2.0 0.015 15.8 0.0 7.6 7 1 1 8 8 8 2 HEAT-like repeat HEAT_2 PF13646.6 EXF82741.1 - 3.2e-10 40.2 8.5 0.1 13.0 0.1 7.8 5 3 3 9 9 9 3 HEAT repeats HEAT PF02985.22 EXF82741.1 - 3.3e-09 36.2 8.1 0.74 10.2 0.0 9.0 9 0 0 9 9 9 2 HEAT repeat Cnd1 PF12717.7 EXF82741.1 - 5e-06 26.6 0.6 2.3 8.3 0.0 6.1 5 2 2 7 7 7 1 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 EXF82741.1 - 8.7e-05 23.0 0.2 1.2 9.8 0.0 5.2 6 0 0 6 6 6 1 Vacuolar 14 Fab1-binding region DUF3385 PF11865.8 EXF82741.1 - 0.00015 21.7 0.5 0.016 15.1 0.0 4.2 5 1 0 5 5 5 1 Domain of unknown function (DUF3385) NUC173 PF08161.12 EXF82741.1 - 0.0002 21.1 0.9 0.95 9.1 0.0 4.2 5 1 0 5 5 5 2 NUC173 domain Adaptin_N PF01602.20 EXF82741.1 - 0.00052 18.7 0.2 0.21 10.1 0.0 3.2 2 2 0 3 3 3 2 Adaptin N terminal region UME PF08064.13 EXF82741.1 - 0.00082 19.2 0.0 2.4 8.1 0.0 4.5 4 0 0 4 4 4 1 UME (NUC010) domain UNC45-central PF11701.8 EXF82741.1 - 0.0025 17.8 0.0 0.0075 16.2 0.0 1.8 2 0 0 2 2 1 1 Myosin-binding striated muscle assembly central CLASP_N PF12348.8 EXF82741.1 - 0.016 14.8 0.0 1.8 8.0 0.0 3.6 4 0 0 4 4 4 0 CLASP N terminal DRIM PF07539.12 EXF82741.1 - 0.04 12.2 0.2 7 4.8 0.0 3.7 2 1 2 4 4 4 0 Down-regulated in metastasis zf-C2HC5 PF06221.13 EXF82742.1 - 1.2e-21 76.4 5.6 1.9e-21 75.8 5.6 1.3 1 0 0 1 1 1 1 Putative zinc finger motif, C2HC5-type MIP-T3_C PF17749.1 EXF82742.1 - 0.037 14.0 1.0 0.094 12.7 1.0 1.6 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 C-terminal region Tropomodulin PF03250.14 EXF82742.1 - 0.069 13.2 0.9 0.13 12.3 0.9 1.5 1 0 0 1 1 1 0 Tropomodulin FYVE PF01363.21 EXF82742.1 - 0.083 13.0 1.3 0.14 12.3 1.3 1.4 1 0 0 1 1 1 0 FYVE zinc finger zf-ribbon_3 PF13248.6 EXF82742.1 - 0.12 11.9 1.8 2.9 7.4 0.2 2.5 2 0 0 2 2 2 0 zinc-ribbon domain FAM176 PF14851.6 EXF82742.1 - 0.72 9.5 4.1 1.5 8.4 4.1 1.5 1 0 0 1 1 1 0 FAM176 family Whi5 PF08528.11 EXF82743.1 - 1.6e-11 43.5 0.0 3.5e-11 42.5 0.0 1.6 1 0 0 1 1 1 1 Whi5 like Rick_17kDa_Anti PF05433.15 EXF82744.1 - 3.7e-05 23.5 24.3 4.5e-05 23.2 16.1 2.6 2 0 0 2 2 2 2 Glycine zipper 2TM domain DUF2076 PF09849.9 EXF82744.1 - 0.00073 19.7 8.7 0.00073 19.7 8.7 2.1 1 1 1 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2076) Glyco_hydro_3_C PF01915.22 EXF82745.1 - 1.7e-52 178.4 0.4 3e-51 174.3 0.1 2.3 2 0 0 2 2 2 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 EXF82745.1 - 5.3e-44 150.9 0.0 9.4e-44 150.1 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 EXF82745.1 - 3.4e-24 84.7 0.2 9e-24 83.4 0.0 1.9 2 0 0 2 2 2 1 Fibronectin type III-like domain Tannase PF07519.11 EXF82746.1 - 1.9e-51 175.5 0.1 2.1e-51 175.3 0.1 1.0 1 0 0 1 1 1 1 Tannase and feruloyl esterase MFS_1 PF07690.16 EXF82747.1 - 8.4e-25 87.4 28.1 8.4e-25 87.4 28.1 1.3 2 0 0 2 2 2 1 Major Facilitator Superfamily Lipase_GDSL_2 PF13472.6 EXF82749.1 - 4.3e-17 63.1 0.5 6e-17 62.6 0.5 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EXF82749.1 - 4.1e-11 43.3 0.0 6e-11 42.7 0.0 1.3 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase HPS3_C PF14763.6 EXF82749.1 - 0.093 12.1 0.0 0.13 11.6 0.0 1.1 1 0 0 1 1 1 0 Hermansky-Pudlak syndrome 3, C-terminal DAO PF01266.24 EXF82750.1 - 5.1e-32 111.8 0.3 7.7e-30 104.6 0.3 2.0 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EXF82750.1 - 0.13 12.5 0.4 0.44 10.8 0.1 2.1 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain SBP_bac_3 PF00497.20 EXF82751.1 - 2.8e-28 98.9 0.1 6.9e-28 97.6 0.1 1.6 1 1 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Methyltransf_23 PF13489.6 EXF82753.1 - 9.3e-13 48.3 0.2 1.4e-11 44.5 0.0 2.2 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF82753.1 - 0.00075 20.2 0.0 0.0058 17.3 0.0 2.4 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF82753.1 - 0.03 14.1 0.0 2.9 7.7 0.0 2.4 2 0 0 2 2 2 0 Methyltransferase domain 3H PF02829.14 EXF82753.1 - 0.087 13.1 0.0 0.57 10.5 0.0 2.1 2 0 0 2 2 2 0 3H domain Methyltransf_11 PF08241.12 EXF82753.1 - 0.098 13.3 0.0 0.49 11.1 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase domain BNR PF02012.20 EXF82754.1 - 6.6e-11 40.5 16.5 0.26 11.4 0.1 6.7 6 0 0 6 6 6 4 BNR/Asp-box repeat BNR_2 PF13088.6 EXF82754.1 - 2.9e-07 30.1 0.0 0.0014 18.0 0.0 2.8 1 1 1 2 2 2 2 BNR repeat-like domain Sortilin-Vps10 PF15902.5 EXF82754.1 - 9.7e-07 27.9 0.0 0.25 10.1 0.0 3.9 2 2 2 5 5 5 3 Sortilin, neurotensin receptor 3, CHB_HEX_C PF03174.13 EXF82754.1 - 0.0048 16.9 0.1 27 4.8 0.0 3.6 4 0 0 4 4 4 1 Chitobiase/beta-hexosaminidase C-terminal domain Lipase_GDSL_2 PF13472.6 EXF82756.1 - 2.2e-06 28.2 1.9 3.1e-06 27.7 1.8 1.3 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EXF82756.1 - 0.00084 19.4 0.0 0.001 19.1 0.0 1.3 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase RasGAP_C PF03836.15 EXF82756.1 - 0.22 11.7 0.0 26 5.0 0.0 2.2 2 0 0 2 2 2 0 RasGAP C-terminus Glyco_hydro_6 PF01341.17 EXF82757.1 - 9.2e-100 334.3 1.6 1.1e-99 334.0 1.6 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 6 MFS_1 PF07690.16 EXF82758.1 - 4.3e-16 58.8 39.4 1.6e-13 50.3 17.5 2.4 2 1 1 3 3 3 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF82758.1 - 3.3e-08 32.8 9.2 3.3e-08 32.8 9.2 2.7 2 1 0 2 2 2 1 Sugar (and other) transporter GRDP-like PF07173.12 EXF82759.1 - 5.6e-15 56.2 1.3 1.7e-11 44.9 0.0 3.2 2 1 1 3 3 3 2 Glycine-rich domain-containing protein-like TGT PF01702.18 EXF82759.1 - 0.12 11.5 0.8 3 6.9 0.2 3.0 4 0 0 4 4 4 0 Queuine tRNA-ribosyltransferase NUDIX PF00293.28 EXF82761.1 - 9.2e-08 32.2 0.0 2.9e-07 30.6 0.0 2.0 1 1 0 1 1 1 1 NUDIX domain Slx4 PF09494.10 EXF82762.1 - 7.9e-24 83.4 0.0 1.8e-23 82.2 0.0 1.6 2 0 0 2 2 2 1 Slx4 endonuclease AT_hook PF02178.19 EXF82762.1 - 0.28 11.2 29.5 0.036 13.9 3.9 5.0 3 0 0 3 3 3 0 AT hook motif Ribosomal_S21e PF01249.18 EXF82763.1 - 1.2e-40 137.4 0.1 1.4e-40 137.3 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S21e Glyco_hydro2_C5 PF18565.1 EXF82763.1 - 0.024 14.4 0.0 0.03 14.2 0.0 1.2 1 0 0 1 1 1 0 Glycoside hydrolase family 2 C-terminal domain 5 Haem_oxygenas_2 PF14518.6 EXF82763.1 - 0.1 12.4 0.0 0.1 12.3 0.0 1.1 1 0 0 1 1 1 0 Iron-containing redox enzyme MFS_1 PF07690.16 EXF82764.1 - 4.4e-33 114.7 31.2 5.3e-33 114.4 31.2 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_4 PF06779.14 EXF82764.1 - 9e-06 25.2 6.2 9e-06 25.2 6.2 2.2 2 0 0 2 2 2 2 Uncharacterised MFS-type transporter YbfB COesterase PF00135.28 EXF82765.1 - 7.3e-92 308.9 0.0 9.1e-92 308.5 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EXF82765.1 - 6.9e-07 29.3 0.1 3.3e-06 27.1 0.1 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Malic_M PF03949.15 EXF82766.1 - 7.1e-89 297.5 0.0 9.7e-89 297.0 0.0 1.2 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 EXF82766.1 - 2.4e-62 209.9 0.0 3.5e-62 209.4 0.0 1.2 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain GHL10 PF02638.15 EXF82766.1 - 0.087 11.9 0.1 5.6 5.9 0.0 2.3 2 0 0 2 2 2 0 Glycosyl hydrolase-like 10 DUF5427 PF10310.9 EXF82767.1 - 1.3e-181 604.7 0.0 1.4e-181 604.5 0.0 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5427) Flu_M1_C PF08289.11 EXF82767.1 - 0.035 14.3 0.3 0.099 12.9 0.3 1.7 1 0 0 1 1 1 0 Influenza Matrix protein (M1) C-terminal domain DUF1631 PF07793.11 EXF82767.1 - 0.91 7.9 9.4 1.4 7.3 9.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1631) Ndc1_Nup PF09531.10 EXF82767.1 - 3.6 6.2 4.5 4.9 5.7 4.5 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Ribosomal_L14 PF00238.19 EXF82769.1 - 9.7e-33 112.8 0.0 1.2e-32 112.6 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e FAD_binding_4 PF01565.23 EXF82770.1 - 2.6e-27 95.3 2.0 3.8e-27 94.7 2.0 1.3 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EXF82770.1 - 1.2e-12 47.7 0.0 2.4e-12 46.8 0.0 1.5 1 0 0 1 1 1 1 Berberine and berberine like XLF PF09302.11 EXF82771.1 - 3.6e-57 193.4 0.3 5.3e-57 192.9 0.3 1.2 1 0 0 1 1 1 1 XLF-Cernunnos, XRcc4-like factor, NHEJ component GAGA PF09237.11 EXF82771.1 - 0.1 12.4 0.4 0.26 11.1 0.4 1.6 1 0 0 1 1 1 0 GAGA factor Forkhead PF00250.18 EXF82772.1 - 7.4e-21 74.2 0.2 2.7e-20 72.4 0.2 1.9 1 0 0 1 1 1 1 Forkhead domain Cactin_mid PF10312.9 EXF82773.1 - 9.2e-66 221.4 8.1 1.2e-65 220.9 8.1 1.2 1 0 0 1 1 1 1 Conserved mid region of cactin CactinC_cactus PF09732.9 EXF82773.1 - 6.1e-51 171.6 1.9 1.1e-50 170.8 1.9 1.4 1 0 0 1 1 1 1 Cactus-binding C-terminus of cactin protein SF3A2 PF16835.5 EXF82773.1 - 0.0063 16.9 0.1 0.03 14.7 0.0 2.1 2 0 0 2 2 2 1 Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) DUF1087 PF06465.13 EXF82773.1 - 0.17 12.0 2.2 0.61 10.2 0.2 2.4 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1087) FAD_binding_7 PF03441.14 EXF82774.1 - 1.7e-82 275.8 3.7 2.7e-82 275.1 0.2 2.6 3 1 0 3 3 3 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.18 EXF82774.1 - 1.2e-37 129.4 0.0 2e-37 128.7 0.0 1.3 1 0 0 1 1 1 1 DNA photolyase Cellulase PF00150.18 EXF82775.1 - 1.8e-52 178.5 7.3 2.4e-52 178.1 7.3 1.1 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) CBM_1 PF00734.18 EXF82775.1 - 3e-12 46.3 14.1 3e-12 46.3 14.1 2.9 3 0 0 3 3 3 1 Fungal cellulose binding domain Hemerythrin PF01814.23 EXF82776.1 - 2.8e-10 40.9 0.0 4.1e-10 40.4 0.0 1.2 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain adh_short PF00106.25 EXF82777.1 - 3.8e-20 72.2 0.0 5.7e-20 71.6 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF82777.1 - 6.9e-12 45.4 0.0 8.7e-12 45.1 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase GDP_Man_Dehyd PF16363.5 EXF82777.1 - 4.8e-06 26.2 0.0 1.2e-05 24.9 0.0 1.7 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 EXF82777.1 - 3.3e-05 23.5 0.0 5.9e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family KR PF08659.10 EXF82777.1 - 0.0012 18.8 0.0 0.0015 18.5 0.0 1.1 1 0 0 1 1 1 1 KR domain Sigma54_activ_2 PF14532.6 EXF82777.1 - 0.023 14.8 0.0 0.039 14.1 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain Beta-lactamase PF00144.24 EXF82778.1 - 2.6e-65 220.8 0.0 3.4e-65 220.5 0.0 1.0 1 0 0 1 1 1 1 Beta-lactamase Zn_clus PF00172.18 EXF82779.1 - 4.9e-08 33.0 12.3 1.1e-07 31.9 12.3 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Dabb PF07876.12 EXF82781.1 - 1.9e-05 25.2 0.0 2.4e-05 24.9 0.0 1.3 1 1 0 1 1 1 1 Stress responsive A/B Barrel Domain Topo_Zn_Ribbon PF08272.11 EXF82781.1 - 0.2 11.3 0.4 0.42 10.3 0.0 1.7 2 0 0 2 2 2 0 Topoisomerase I zinc-ribbon-like Uds1 PF15456.6 EXF82782.1 - 0.018 15.2 0.3 0.033 14.3 0.3 1.4 1 0 0 1 1 1 0 Up-regulated During Septation 2OG-FeII_Oxy_3 PF13640.6 EXF82784.1 - 1.6e-05 25.7 0.0 3e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily RdRP PF05183.12 EXF82785.1 - 1.3e-181 605.3 0.0 1.6e-181 604.9 0.0 1.1 1 0 0 1 1 1 1 RNA dependent RNA polymerase RRM_1 PF00076.22 EXF82785.1 - 1.1e-05 25.1 0.0 5.8e-05 22.8 0.0 2.3 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FAD-oxidase_C PF02913.19 EXF82786.1 - 4.9e-60 203.3 0.0 7.1e-60 202.7 0.0 1.2 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 EXF82786.1 - 1e-33 116.0 0.1 2.6e-33 114.7 0.0 1.8 2 0 0 2 2 2 1 FAD binding domain SepSecS PF05889.13 EXF82786.1 - 0.19 10.4 0.0 0.3 9.7 0.0 1.2 1 0 0 1 1 1 0 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS Pkinase PF00069.25 EXF82788.1 - 2.1e-36 125.7 0.0 4.1e-36 124.7 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF82788.1 - 1.4e-07 31.1 0.0 2.5e-07 30.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EXF82788.1 - 0.0011 19.0 0.2 1.7 8.5 0.0 3.2 2 1 1 3 3 3 2 Phosphotransferase enzyme family KIX_2 PF16987.5 EXF82788.1 - 0.0013 18.7 0.4 0.0037 17.2 0.4 1.8 1 0 0 1 1 1 1 KIX domain zf-RING_2 PF13639.6 EXF82789.1 - 1.5e-08 34.8 9.1 3e-08 33.9 9.1 1.5 1 0 0 1 1 1 1 Ring finger domain FANCL_C PF11793.8 EXF82789.1 - 1.1e-05 25.5 8.4 3.3e-05 24.0 8.4 1.8 1 1 0 1 1 1 1 FANCL C-terminal domain zf-rbx1 PF12678.7 EXF82789.1 - 0.00021 21.5 7.3 0.00052 20.2 7.3 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 EXF82789.1 - 0.00029 20.8 2.4 0.00077 19.5 2.4 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4 PF00097.25 EXF82789.1 - 0.0016 18.3 9.7 0.0032 17.3 9.7 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) RINGv PF12906.7 EXF82789.1 - 0.0023 18.0 7.8 0.0049 17.0 7.8 1.6 1 0 0 1 1 1 1 RING-variant domain C1_1 PF00130.22 EXF82789.1 - 0.0039 17.1 2.8 0.0039 17.1 2.8 1.8 1 1 1 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Zn_ribbon_17 PF17120.5 EXF82789.1 - 0.021 14.4 5.2 0.042 13.5 5.2 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-C3HC4_3 PF13920.6 EXF82789.1 - 0.027 14.3 5.8 0.052 13.4 5.8 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EXF82789.1 - 0.044 13.6 8.1 0.087 12.7 8.1 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING-like PF08746.11 EXF82789.1 - 0.08 13.3 8.0 0.16 12.3 8.0 1.5 1 0 0 1 1 1 0 RING-like domain Prok-RING_4 PF14447.6 EXF82789.1 - 0.64 9.9 6.7 1.9 8.4 6.8 1.8 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_9 PF13901.6 EXF82789.1 - 0.98 9.4 8.4 1.1 9.2 6.3 2.1 2 0 0 2 2 2 0 Putative zinc-RING and/or ribbon PHD PF00628.29 EXF82789.1 - 2.3 8.2 7.1 4.8 7.2 7.1 1.6 1 0 0 1 1 1 0 PHD-finger zf-RING_5 PF14634.6 EXF82789.1 - 6.4 6.8 8.8 12 6.0 8.8 1.5 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_4 PF14570.6 EXF82789.1 - 6.8 6.6 7.7 2.3e+02 1.7 7.7 2.4 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain Hid1 PF12722.7 EXF82791.1 - 0.99 7.5 5.2 1 7.4 5.2 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Adeno_terminal PF02459.15 EXF82792.1 - 1.3 7.3 3.3 2.2 6.6 3.3 1.2 1 0 0 1 1 1 0 Adenoviral DNA terminal protein Ribosomal_L1 PF00687.21 EXF82793.1 - 1.5e-66 224.0 1.1 1.5e-66 224.0 1.1 1.8 2 0 0 2 2 2 1 Ribosomal protein L1p/L10e family ALF PF03752.13 EXF82793.1 - 7.7 6.6 6.1 1.4 8.9 0.3 2.6 3 0 0 3 3 3 0 Short repeats of unknown function Palm_thioest PF02089.15 EXF82794.1 - 1.1e-77 261.2 0.0 1.4e-77 260.9 0.0 1.1 1 0 0 1 1 1 1 Palmitoyl protein thioesterase DUF915 PF06028.11 EXF82794.1 - 0.0038 16.6 0.0 0.053 12.8 0.0 2.3 3 0 0 3 3 3 1 Alpha/beta hydrolase of unknown function (DUF915) Cyclin_N PF00134.23 EXF82795.1 - 9.5e-08 31.8 0.1 1.8e-07 30.9 0.1 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Yos1 PF08571.10 EXF82795.1 - 0.07 13.4 0.0 0.15 12.3 0.0 1.5 1 0 0 1 1 1 0 Yos1-like Abhydrolase_1 PF00561.20 EXF82797.1 - 2.7e-21 76.4 0.0 3.6e-17 62.8 0.0 2.4 2 1 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_4 PF08386.10 EXF82797.1 - 3.9e-17 62.2 0.0 8e-17 61.2 0.0 1.5 1 0 0 1 1 1 1 TAP-like protein RTA1 PF04479.13 EXF82798.1 - 2.2e-54 184.2 6.2 3.6e-54 183.5 6.2 1.3 1 0 0 1 1 1 1 RTA1 like protein Fungal_trans PF04082.18 EXF82799.1 - 1.7e-16 60.1 0.1 2.7e-16 59.4 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain ketoacyl-synt PF00109.26 EXF82799.1 - 6.7e-06 25.9 0.0 1.1e-05 25.2 0.0 1.3 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Gar1 PF04410.14 EXF82800.1 - 1.5e-46 158.0 0.4 3.2e-46 156.9 0.4 1.5 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region Cwf_Cwc_15 PF04889.12 EXF82800.1 - 0.46 10.2 8.8 0.31 10.7 2.5 2.4 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein GRP PF07172.11 EXF82800.1 - 1.1 10.0 16.7 2.4 8.9 5.3 2.4 2 0 0 2 2 2 0 Glycine rich protein family SH3_9 PF14604.6 EXF82801.1 - 1.3e-10 40.9 0.0 2.1e-10 40.3 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EXF82801.1 - 3.3e-06 26.6 0.0 5.5e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 EXF82801.1 - 0.00013 21.6 0.0 0.00022 20.8 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain SKG6 PF08693.10 EXF82801.1 - 0.0082 15.5 0.0 0.0082 15.5 0.0 2.9 3 0 0 3 3 2 1 Transmembrane alpha-helix domain Glycophorin_A PF01102.18 EXF82801.1 - 0.011 16.0 1.2 0.021 15.1 0.3 1.9 1 1 0 1 1 1 0 Glycophorin A RIFIN PF02009.16 EXF82801.1 - 0.021 14.8 1.0 0.032 14.1 1.0 1.2 1 0 0 1 1 1 0 Rifin DUF5305 PF17231.2 EXF82801.1 - 0.028 13.8 0.1 0.057 12.8 0.1 1.5 1 1 0 1 1 1 0 Family of unknown function (DUF5305) Amnionless PF14828.6 EXF82801.1 - 0.07 11.9 0.1 0.1 11.4 0.1 1.1 1 0 0 1 1 1 0 Amnionless DUF4448 PF14610.6 EXF82801.1 - 0.075 12.8 0.1 0.15 11.8 0.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF4448) ATG22 PF11700.8 EXF82801.1 - 0.079 11.6 0.2 0.11 11.1 0.2 1.1 1 0 0 1 1 1 0 Vacuole effluxer Atg22 like CD34_antigen PF06365.12 EXF82801.1 - 0.14 11.7 0.0 0.26 10.8 0.0 1.4 1 0 0 1 1 1 0 CD34/Podocalyxin family ABC2_membrane_3 PF12698.7 EXF82801.1 - 0.17 10.9 0.3 0.26 10.4 0.3 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein Syndecan PF01034.20 EXF82801.1 - 0.2 11.6 0.0 0.37 10.7 0.0 1.3 1 0 0 1 1 1 0 Syndecan domain Ribonucleas_3_3 PF14622.6 EXF82803.1 - 8.7e-05 22.7 0.0 0.064 13.4 0.0 2.4 2 0 0 2 2 2 2 Ribonuclease-III-like dsrm PF00035.26 EXF82803.1 - 0.034 14.8 0.0 0.071 13.8 0.0 1.5 1 0 0 1 1 1 0 Double-stranded RNA binding motif Ribonuclease_3 PF00636.26 EXF82803.1 - 0.12 13.0 0.0 0.57 10.8 0.0 2.1 1 1 0 1 1 1 0 Ribonuclease III domain PLA2_B PF01735.18 EXF82804.1 - 1.6e-27 96.1 0.0 4e-27 94.8 0.0 1.6 1 1 0 1 1 1 1 Lysophospholipase catalytic domain Septin PF00735.18 EXF82805.1 - 2.8e-119 397.6 0.1 2.8e-119 397.6 0.1 1.7 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.23 EXF82805.1 - 2.4e-08 34.0 1.3 4.1e-08 33.3 0.0 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EXF82805.1 - 9.2e-07 28.6 1.2 0.00029 20.4 0.0 3.0 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EXF82805.1 - 2e-05 24.6 2.7 0.003 17.5 1.1 3.3 2 1 0 2 2 2 1 RsgA GTPase ABC_tran PF00005.27 EXF82805.1 - 0.00016 22.2 2.5 0.022 15.3 0.0 2.6 3 0 0 3 3 3 1 ABC transporter AIG1 PF04548.16 EXF82805.1 - 0.00085 18.7 1.5 0.0022 17.4 0.0 2.2 2 0 0 2 2 2 1 AIG1 family Roc PF08477.13 EXF82805.1 - 0.0014 18.8 0.0 0.0032 17.7 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_22 PF13401.6 EXF82805.1 - 0.0016 18.7 0.7 0.012 15.9 0.0 2.6 2 2 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EXF82805.1 - 0.0022 18.4 0.2 0.0053 17.2 0.0 1.7 2 0 0 2 2 1 1 AAA ATPase domain Ras PF00071.22 EXF82805.1 - 0.0055 16.3 0.1 0.041 13.5 0.0 2.3 2 0 0 2 2 2 1 Ras family AAA_29 PF13555.6 EXF82805.1 - 0.014 15.2 0.0 0.025 14.3 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Caldesmon PF02029.15 EXF82805.1 - 0.044 12.6 17.6 0.067 11.9 17.6 1.2 1 0 0 1 1 1 0 Caldesmon FtsK_SpoIIIE PF01580.18 EXF82805.1 - 0.047 13.0 0.0 0.12 11.7 0.0 1.7 1 0 0 1 1 1 0 FtsK/SpoIIIE family RNA_helicase PF00910.22 EXF82805.1 - 0.053 13.9 0.6 0.58 10.6 0.0 2.5 2 0 0 2 2 2 0 RNA helicase AAA_24 PF13479.6 EXF82805.1 - 0.065 12.9 0.0 0.14 11.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain Dynamin_N PF00350.23 EXF82805.1 - 0.077 13.1 8.9 0.85 9.6 0.0 3.7 4 1 0 4 4 3 0 Dynamin family AAA_7 PF12775.7 EXF82805.1 - 0.094 12.2 0.0 0.19 11.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region ATP_bind_1 PF03029.17 EXF82805.1 - 0.13 12.0 2.3 7.9 6.2 0.0 3.2 3 1 0 3 3 3 0 Conserved hypothetical ATP binding protein Exonuc_VII_L PF02601.15 EXF82805.1 - 0.17 11.4 6.2 0.27 10.8 6.2 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit AAA_5 PF07728.14 EXF82805.1 - 0.19 11.7 1.1 3.1 7.8 0.0 2.8 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) DUF87 PF01935.17 EXF82805.1 - 3 7.9 7.1 4.6 7.3 0.0 2.6 3 0 0 3 3 3 0 Helicase HerA, central domain Atg14 PF10186.9 EXF82805.1 - 3.2 6.7 8.0 5.3 6.0 8.0 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 S4 PF01479.25 EXF82806.1 - 5.4e-13 48.4 0.0 1.7e-12 46.8 0.0 1.9 2 0 0 2 2 2 1 S4 domain S4_2 PF13275.6 EXF82806.1 - 0.0045 16.8 0.0 0.0091 15.8 0.0 1.4 1 0 0 1 1 1 1 S4 domain DUF4011 PF13195.6 EXF82806.1 - 1.8 8.5 4.9 3.6 7.5 0.2 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF4011) La PF05383.17 EXF82807.1 - 3.4e-20 71.8 0.0 6.4e-20 71.0 0.0 1.5 1 0 0 1 1 1 1 La domain RRM_1 PF00076.22 EXF82807.1 - 1.2e-10 41.0 0.1 2.4e-10 40.1 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MFS_1 PF07690.16 EXF82808.1 - 3.9e-41 141.1 28.4 3.9e-41 141.1 28.4 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF82808.1 - 6.8e-11 41.7 1.2 6.8e-11 41.7 1.2 1.9 2 0 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 EXF82808.1 - 4.5e-05 22.1 0.3 6.6e-05 21.5 0.3 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF4179 PF13786.6 EXF82808.1 - 0.22 12.0 3.0 22 5.6 0.1 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4179) CCDC106 PF15794.5 EXF82808.1 - 3.3 7.4 6.8 4.8 6.8 6.8 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 T4BSS_DotI_IcmL PF11393.8 EXF82809.1 - 0.13 11.8 0.0 0.21 11.1 0.0 1.3 1 0 0 1 1 1 0 Type-IV b secretion system, inner-membrane complex component Clr5 PF14420.6 EXF82810.1 - 6.4e-10 39.1 0.4 1.3e-09 38.2 0.4 1.6 1 0 0 1 1 1 1 Clr5 domain TPR_12 PF13424.6 EXF82810.1 - 0.027 14.8 3.8 0.84 10.0 0.4 3.6 3 1 2 5 5 5 0 Tetratricopeptide repeat TPR_19 PF14559.6 EXF82810.1 - 0.032 14.7 0.2 6.3 7.4 0.0 3.0 3 1 0 3 3 3 0 Tetratricopeptide repeat PPR PF01535.20 EXF82810.1 - 0.091 13.1 0.2 5.2 7.6 0.0 3.0 3 0 0 3 3 3 0 PPR repeat Fungal_lectin PF07938.12 EXF82811.1 - 0.027 13.8 0.0 0.09 12.1 0.0 1.8 2 0 0 2 2 2 0 Fungal fucose-specific lectin Pro_dh PF01619.18 EXF82812.1 - 8.2e-59 199.5 0.0 1e-58 199.2 0.0 1.1 1 0 0 1 1 1 1 Proline dehydrogenase AP_endonuc_2 PF01261.24 EXF82812.1 - 0.025 14.0 0.0 0.057 12.9 0.0 1.6 2 0 0 2 2 2 0 Xylose isomerase-like TIM barrel AA_permease PF00324.21 EXF82813.1 - 2e-121 405.9 40.7 3.3e-120 401.9 40.7 1.9 1 1 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EXF82813.1 - 5e-40 137.6 36.5 2.3e-39 135.4 36.5 1.7 1 1 0 1 1 1 1 Amino acid permease Glyco_transf_22 PF03901.17 EXF82814.1 - 3.2e-76 257.2 16.5 1.6e-58 198.9 8.9 2.0 1 1 1 2 2 2 2 Alg9-like mannosyltransferase family DUF4321 PF14209.6 EXF82814.1 - 0.27 11.1 0.1 0.27 11.1 0.1 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4321) UPF0121 PF03661.13 EXF82815.1 - 2.4e-28 99.1 6.0 3.2e-28 98.7 6.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0121) DSPc PF00782.20 EXF82816.1 - 7.3e-09 35.5 0.0 1.4e-08 34.7 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EXF82816.1 - 0.00014 21.6 0.0 0.00026 20.6 0.0 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 EXF82816.1 - 0.024 14.6 0.0 0.039 13.9 0.0 1.2 1 0 0 1 1 1 0 Tyrosine phosphatase family UPF0242 PF06785.11 EXF82817.1 - 0.049 13.7 1.0 0.056 13.6 1.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Glucokinase PF02685.16 EXF82817.1 - 0.18 10.7 0.0 0.24 10.3 0.0 1.1 1 0 0 1 1 1 0 Glucokinase RicinB_lectin_2 PF14200.6 EXF82818.1 - 1e-06 29.4 2.6 5.9e-05 23.7 0.5 2.6 1 1 2 3 3 3 3 Ricin-type beta-trefoil lectin domain-like CDtoxinA PF03498.14 EXF82818.1 - 0.009 15.6 0.0 0.015 14.9 0.0 1.3 1 0 0 1 1 1 1 Cytolethal distending toxin A/C domain Mid2 PF04478.12 EXF82818.1 - 0.025 14.4 0.0 0.052 13.4 0.0 1.4 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor Adeno_E3_CR2 PF02439.15 EXF82818.1 - 0.028 14.2 0.8 0.068 12.9 0.8 1.6 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Syndecan PF01034.20 EXF82818.1 - 0.03 14.2 0.0 0.056 13.4 0.0 1.4 1 0 0 1 1 1 0 Syndecan domain Ricin_B_lectin PF00652.22 EXF82818.1 - 0.13 12.6 0.2 0.32 11.2 0.3 1.7 2 0 0 2 2 2 0 Ricin-type beta-trefoil lectin domain EphA2_TM PF14575.6 EXF82818.1 - 0.2 12.6 0.0 0.38 11.7 0.0 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Linker_histone PF00538.19 EXF82819.1 - 7.9e-28 96.6 0.1 7.9e-28 96.6 0.1 2.1 2 1 0 2 2 2 1 linker histone H1 and H5 family Asp-B-Hydro_N PF05279.11 EXF82819.1 - 5 7.1 31.2 6.5 6.7 31.2 1.3 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region HRI1 PF16815.5 EXF82820.1 - 1.5e-56 191.7 0.7 1.8e-56 191.4 0.7 1.0 1 0 0 1 1 1 1 Protein HRI1 FA_hydroxylase PF04116.13 EXF82822.1 - 1.6e-11 44.6 9.2 5.5e-11 42.9 9.2 1.8 1 1 0 1 1 1 1 Fatty acid hydroxylase superfamily Glyco_transf_90 PF05686.12 EXF82823.1 - 1.5e-11 43.8 0.7 6.6e-10 38.5 0.7 2.6 2 1 0 2 2 2 2 Glycosyl transferase family 90 MFS_1 PF07690.16 EXF82824.1 - 1.2e-30 106.6 29.9 1.2e-30 106.6 29.9 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF2649 PF10854.8 EXF82824.1 - 1.1 9.6 5.8 0.38 11.1 1.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2649) SKG6 PF08693.10 EXF82825.1 - 0.002 17.5 1.1 0.0061 15.9 1.1 1.8 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Gram_pos_anchor PF00746.21 EXF82825.1 - 0.054 13.4 0.3 0.054 13.4 0.3 4.2 3 1 1 4 4 4 0 LPXTG cell wall anchor motif MLANA PF14991.6 EXF82825.1 - 0.057 13.7 0.0 0.13 12.6 0.0 1.5 1 0 0 1 1 1 0 Protein melan-A Metallophos_2 PF12850.7 EXF82827.1 - 1.1e-11 45.2 0.0 4.7e-07 30.2 0.0 2.4 2 0 0 2 2 2 2 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.28 EXF82827.1 - 3.8e-11 43.9 0.0 6.8e-11 43.1 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Transp_inhibit PF18791.1 EXF82827.1 - 0.14 11.7 0.1 0.37 10.3 0.1 1.7 1 0 0 1 1 1 0 Transport inhibitor response 1 protein domain NAD_binding_6 PF08030.12 EXF82828.1 - 3.3e-31 108.5 0.0 6.6e-31 107.5 0.0 1.5 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EXF82828.1 - 1.6e-19 70.0 1.2 3.6e-19 68.9 0.0 2.2 2 0 0 2 2 2 1 FAD-binding domain Ferric_reduct PF01794.19 EXF82828.1 - 3.9e-17 62.5 12.3 3.9e-17 62.5 12.3 2.4 1 1 1 2 2 2 1 Ferric reductase like transmembrane component UQ_con PF00179.26 EXF82829.1 - 1.6e-52 176.8 0.0 1.8e-52 176.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EXF82829.1 - 0.0048 16.6 0.0 0.0059 16.3 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 EXF82829.1 - 0.037 14.3 0.0 0.045 14.0 0.0 1.2 1 0 0 1 1 1 0 RWD domain UEV PF05743.13 EXF82829.1 - 0.046 13.6 0.0 0.072 13.0 0.0 1.3 1 0 0 1 1 1 0 UEV domain Acyl-CoA_dh_N PF02771.16 EXF82830.1 - 1.5e-26 93.3 0.7 3.6e-26 92.0 0.7 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_1 PF00441.24 EXF82830.1 - 3.6e-22 79.2 0.1 6.2e-22 78.4 0.1 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 EXF82830.1 - 1.1e-17 64.0 0.0 2.5e-17 62.9 0.0 1.7 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 EXF82830.1 - 1.3e-05 25.5 0.1 2.6e-05 24.5 0.1 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain ADK PF00406.22 EXF82832.1 - 6.3e-09 36.1 0.0 8.4e-09 35.7 0.0 1.2 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 EXF82832.1 - 2.9e-05 24.5 0.0 4.7e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.17 EXF82832.1 - 0.068 12.8 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 Thymidylate kinase Radical_SAM PF04055.21 EXF82833.1 - 8.6e-15 55.5 0.3 1.8e-14 54.5 0.3 1.6 1 1 0 1 1 1 1 Radical SAM superfamily Fer4_12 PF13353.6 EXF82833.1 - 1.1e-06 28.9 0.1 3.9e-06 27.2 0.0 1.8 2 0 0 2 2 2 1 4Fe-4S single cluster domain Fer4_14 PF13394.6 EXF82833.1 - 0.00026 21.1 0.1 0.00085 19.4 0.0 1.9 2 0 0 2 2 2 1 4Fe-4S single cluster domain DUF3176 PF11374.8 EXF82834.1 - 3e-34 117.4 0.5 5.8e-34 116.5 0.5 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3176) SYS1 PF09801.9 EXF82835.1 - 1.4e-45 155.0 0.1 1.5e-45 154.8 0.1 1.0 1 0 0 1 1 1 1 Integral membrane protein S linking to the trans Golgi network TPPK_C PF12555.8 EXF82835.1 - 0.0079 16.2 0.6 0.0079 16.2 0.6 2.7 3 0 0 3 3 3 1 Thiamine pyrophosphokinase C terminal COX6B PF02297.17 EXF82836.1 - 1.4e-23 82.9 3.7 1.9e-23 82.5 3.7 1.2 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb IL28A PF15177.6 EXF82836.1 - 0.0063 16.4 0.2 0.011 15.6 0.1 1.4 1 1 0 1 1 1 1 Interleukin-28A PIP5K PF01504.18 EXF82837.1 - 1e-101 339.7 0.2 2.1e-101 338.7 0.2 1.5 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase Fungal_trans PF04082.18 EXF82838.1 - 4.9e-05 22.5 0.2 0.00018 20.6 0.1 1.9 2 0 0 2 2 2 1 Fungal specific transcription factor domain p450 PF00067.22 EXF82839.1 - 7.4e-66 222.8 0.0 1.1e-65 222.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Gti1_Pac2 PF09729.9 EXF82840.1 - 8.2e-43 146.6 5.8 1.5e-36 126.2 0.2 2.6 2 1 1 3 3 3 2 Gti1/Pac2 family EphA2_TM PF14575.6 EXF82841.1 - 0.068 14.1 0.1 0.24 12.3 0.0 2.1 2 1 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain ALMT PF11744.8 EXF82842.1 - 8.8 5.0 8.6 12 4.6 8.6 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Amidase PF01425.21 EXF82843.1 - 6.2e-64 216.6 0.0 1.1e-63 215.8 0.0 1.4 1 0 0 1 1 1 1 Amidase DUF3759 PF12585.8 EXF82844.1 - 1.6 8.9 10.1 0.26 11.3 5.0 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3759) PAS_3 PF08447.12 EXF82845.1 - 1e-13 51.4 0.0 2.3e-13 50.2 0.0 1.6 1 0 0 1 1 1 1 PAS fold PAS PF00989.25 EXF82845.1 - 5.7e-07 29.5 0.1 1.5e-06 28.1 0.0 1.7 2 0 0 2 2 2 1 PAS fold PAS_9 PF13426.7 EXF82845.1 - 8.7e-05 22.7 0.1 0.00032 20.9 0.0 1.9 2 0 0 2 2 2 1 PAS domain PAS_4 PF08448.10 EXF82845.1 - 0.00073 19.8 0.0 0.0016 18.7 0.0 1.6 1 0 0 1 1 1 1 PAS fold PAS_11 PF14598.6 EXF82845.1 - 0.0039 17.3 0.0 0.0074 16.4 0.0 1.4 1 0 0 1 1 1 1 PAS domain DUF4428 PF14471.6 EXF82845.1 - 0.045 13.7 2.2 0.17 11.8 0.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4428) AAA_23 PF13476.6 EXF82846.1 - 5.2e-25 89.1 33.3 5.2e-25 89.1 33.3 7.1 1 1 3 5 5 3 1 AAA domain AAA_21 PF13304.6 EXF82846.1 - 2.4e-10 40.7 6.2 0.00012 22.0 2.3 3.5 3 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system SbcCD_C PF13558.6 EXF82846.1 - 6.5e-07 29.5 0.0 2.4e-06 27.7 0.0 2.1 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_15 PF13175.6 EXF82846.1 - 0.00012 21.9 8.5 0.00012 21.9 8.5 5.8 1 1 1 4 4 4 2 AAA ATPase domain AAA_29 PF13555.6 EXF82846.1 - 0.0016 18.1 0.0 0.0035 17.0 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain HCMV_UL139 PF12507.8 EXF82846.1 - 0.0052 17.2 0.0 0.0052 17.2 0.0 5.9 5 3 1 6 6 6 1 Human Cytomegalovirus UL139 protein KxDL PF10241.9 EXF82846.1 - 0.056 13.7 0.3 0.056 13.7 0.3 9.6 7 3 3 10 10 10 0 Uncharacterized conserved protein AAA_13 PF13166.6 EXF82846.1 - 0.073 11.7 0.1 0.073 11.7 0.1 6.9 2 1 5 7 7 7 0 AAA domain AAA_16 PF13191.6 EXF82846.1 - 0.086 13.2 0.0 0.086 13.2 0.0 4.5 5 0 0 5 5 5 0 AAA ATPase domain ABC_tran PF00005.27 EXF82846.1 - 0.11 13.0 0.0 0.11 13.0 0.0 6.4 3 2 0 3 3 1 0 ABC transporter SMC_N PF02463.19 EXF82846.1 - 1.1 8.6 63.5 13 5.2 63.5 2.6 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain PPP4R2 PF09184.11 EXF82847.1 - 2.8e-13 50.1 15.9 4.5e-13 49.4 0.0 3.2 2 1 0 3 3 3 1 PPP4R2 Adeno_E3_14_5 PF04834.12 EXF82847.1 - 0.18 12.3 0.2 0.49 11.0 0.2 1.6 1 0 0 1 1 1 0 Early E3 14.5 kDa protein RRF PF01765.19 EXF82848.1 - 7.7e-24 84.5 4.4 1.1e-23 84.0 4.4 1.2 1 0 0 1 1 1 1 Ribosome recycling factor HATPase_c PF02518.26 EXF82850.1 - 1.4e-23 83.5 0.1 2.8e-23 82.5 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EXF82850.1 - 1.1e-20 73.8 0.0 2.4e-20 72.8 0.0 1.6 1 0 0 1 1 1 1 Response regulator receiver domain PAS_9 PF13426.7 EXF82850.1 - 7.3e-07 29.4 0.1 2.2e-05 24.6 0.1 2.9 2 1 1 3 3 3 1 PAS domain HisKA PF00512.25 EXF82850.1 - 8.7e-07 28.9 1.4 1.2e-06 28.5 0.1 2.0 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain PAS_4 PF08448.10 EXF82850.1 - 1.9e-06 28.1 0.0 0.0056 16.9 0.0 2.8 2 0 0 2 2 2 2 PAS fold GAF_2 PF13185.6 EXF82850.1 - 3e-05 24.3 0.0 0.0082 16.4 0.0 2.7 2 0 0 2 2 2 1 GAF domain PAS PF00989.25 EXF82850.1 - 8.3e-05 22.6 0.1 0.0007 19.6 0.0 2.4 2 0 0 2 2 2 1 PAS fold PAS_3 PF08447.12 EXF82850.1 - 0.0015 18.8 0.0 0.0038 17.5 0.0 1.7 1 0 0 1 1 1 1 PAS fold GAF_3 PF13492.6 EXF82850.1 - 0.012 16.0 0.0 0.036 14.4 0.0 1.9 1 0 0 1 1 1 0 GAF domain PAS_8 PF13188.7 EXF82850.1 - 0.054 13.5 0.0 0.44 10.6 0.0 2.4 2 0 0 2 2 2 0 PAS domain DEAD PF00270.29 EXF82853.1 - 1.5e-24 86.7 0.0 3.6e-23 82.2 0.0 2.3 1 1 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EXF82853.1 - 8.5e-24 84.0 0.0 2.4e-23 82.6 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EXF82853.1 - 0.0003 20.9 0.5 0.00078 19.5 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit GP67 PF17634.2 EXF82853.1 - 0.011 16.1 10.9 0.042 14.3 10.9 2.0 1 0 0 1 1 1 0 Gene product 67 CENP-B_dimeris PF09026.10 EXF82853.1 - 0.015 15.7 8.4 0.043 14.2 8.4 1.7 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DNA_pol_phi PF04931.13 EXF82853.1 - 0.43 8.6 13.2 0.7 7.9 11.8 1.9 2 0 0 2 2 2 0 DNA polymerase phi TFB6 PF17110.5 EXF82853.1 - 8.4 6.1 6.6 1.9 8.2 2.0 2.3 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH PH_6 PF15406.6 EXF82854.1 - 2.4e-47 159.8 5.3 2.4e-47 159.8 5.3 3.1 2 0 0 2 2 2 1 Pleckstrin homology domain PH PF00169.29 EXF82854.1 - 4.7e-05 23.9 0.0 0.00014 22.3 0.0 2.0 1 1 0 1 1 1 1 PH domain tRNA-synt_2 PF00152.20 EXF82856.1 - 1.3e-60 205.1 0.0 2.6e-60 204.1 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EXF82856.1 - 2.4e-09 37.0 0.0 4.5e-09 36.2 0.0 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 EXF82856.1 - 0.00014 21.4 0.0 0.052 13.0 0.0 2.4 2 1 0 2 2 2 2 tRNA synthetases class II core domain (F) zf-Tim10_DDP PF02953.15 EXF82857.1 - 7e-19 67.2 1.8 9.1e-19 66.9 1.8 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger DUF2897 PF11446.8 EXF82858.1 - 0.065 13.1 0.0 0.2 11.6 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2897) CLTH PF10607.9 EXF82859.1 - 4.7e-31 107.7 0.0 1.3e-30 106.3 0.0 1.7 2 0 0 2 2 2 1 CTLH/CRA C-terminal to LisH motif domain zf-RING_UBOX PF13445.6 EXF82859.1 - 8.3e-10 38.5 2.6 1.5e-09 37.7 2.6 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 EXF82859.1 - 7.4e-07 29.0 2.1 1.3e-06 28.3 2.1 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EXF82859.1 - 5.7e-05 22.9 2.1 9.7e-05 22.2 2.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EXF82859.1 - 5.8e-05 23.3 2.8 9.9e-05 22.6 2.8 1.4 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 EXF82859.1 - 0.00011 22.0 2.5 0.0002 21.1 2.5 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 EXF82859.1 - 0.00039 20.2 3.5 0.00072 19.4 3.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EXF82859.1 - 0.0006 19.6 3.9 0.0012 18.7 3.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Rtf2 PF04641.12 EXF82859.1 - 0.0021 17.5 0.1 0.0033 16.8 0.1 1.3 1 0 0 1 1 1 1 Rtf2 RING-finger zf-C3HC4_4 PF15227.6 EXF82859.1 - 0.004 17.3 3.4 0.0088 16.2 3.4 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Phage_portal_2 PF05136.13 EXF82859.1 - 0.039 13.1 0.0 0.052 12.7 0.0 1.1 1 0 0 1 1 1 0 Phage portal protein, lambda family zf-RING_4 PF14570.6 EXF82859.1 - 0.094 12.5 2.0 0.17 11.7 2.0 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C2HC5 PF06221.13 EXF82859.1 - 0.12 12.4 0.3 0.24 11.4 0.3 1.4 1 0 0 1 1 1 0 Putative zinc finger motif, C2HC5-type XhlA PF10779.9 EXF82860.1 - 0.014 15.5 0.1 0.043 14.0 0.1 1.8 1 0 0 1 1 1 0 Haemolysin XhlA Spc7 PF08317.11 EXF82860.1 - 0.085 11.7 3.9 0.17 10.7 3.9 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF1664 PF07889.12 EXF82860.1 - 0.11 12.5 2.4 0.29 11.2 1.5 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) HMMR_N PF15905.5 EXF82860.1 - 0.16 11.4 5.1 0.29 10.5 5.1 1.4 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal Laminin_II PF06009.12 EXF82860.1 - 0.26 11.3 3.5 3.6 7.6 0.7 2.8 1 1 2 3 3 3 0 Laminin Domain II PG_binding_1 PF01471.18 EXF82860.1 - 0.61 10.3 1.8 21 5.4 0.0 3.1 3 0 0 3 3 3 0 Putative peptidoglycan binding domain Tropomyosin_1 PF12718.7 EXF82860.1 - 2.4 8.3 9.5 0.14 12.3 1.4 2.7 2 1 0 2 2 2 0 Tropomyosin like ATG16 PF08614.11 EXF82860.1 - 5.1 7.3 10.2 4.7 7.4 6.1 2.3 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) Sugar_tr PF00083.24 EXF82861.1 - 5.1e-47 160.8 3.6 6e-47 160.5 3.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF82861.1 - 2.8e-21 75.8 5.8 3.2e-21 75.6 5.8 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 EXF82861.1 - 1.1e-05 24.1 0.4 1.4e-05 23.8 0.4 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_5 PF05631.14 EXF82861.1 - 0.0028 16.7 1.4 0.0042 16.1 1.4 1.4 1 0 0 1 1 1 1 Sugar-tranasporters, 12 TM Peptidase_A4 PF01828.17 EXF82861.1 - 0.21 11.0 0.1 0.32 10.4 0.1 1.2 1 0 0 1 1 1 0 Peptidase A4 family HET PF06985.11 EXF82862.1 - 1.7e-36 125.7 0.4 4.1e-36 124.5 0.4 1.7 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) FAD_binding_3 PF01494.19 EXF82863.1 - 1.3e-28 100.2 0.0 3.5e-27 95.6 0.0 2.0 1 1 0 1 1 1 1 FAD binding domain Trp_halogenase PF04820.14 EXF82863.1 - 1.2e-06 27.7 3.6 0.033 13.0 0.4 3.1 2 1 1 3 3 3 3 Tryptophan halogenase Pyr_redox_3 PF13738.6 EXF82863.1 - 2.1e-06 27.2 0.4 0.0048 16.2 0.7 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EXF82863.1 - 3.5e-06 26.5 3.0 0.00056 19.2 0.3 2.5 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EXF82863.1 - 1.2e-05 24.2 0.1 0.0022 16.7 0.0 2.2 2 0 0 2 2 2 2 HI0933-like protein DAO PF01266.24 EXF82863.1 - 2e-05 24.3 0.4 0.032 13.8 0.4 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase SE PF08491.10 EXF82863.1 - 0.00023 20.3 0.0 0.0066 15.5 0.0 2.1 2 0 0 2 2 2 1 Squalene epoxidase Lycopene_cycl PF05834.12 EXF82863.1 - 0.00057 19.1 0.1 0.54 9.3 0.1 2.2 2 0 0 2 2 2 2 Lycopene cyclase protein NAD_binding_8 PF13450.6 EXF82863.1 - 0.0023 18.1 0.1 0.0045 17.2 0.1 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 EXF82863.1 - 0.016 14.3 0.1 0.023 13.8 0.1 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A Pyr_redox PF00070.27 EXF82863.1 - 0.031 14.9 0.3 13 6.4 0.0 2.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EXF82863.1 - 0.033 13.3 1.6 0.069 12.2 0.9 1.8 1 1 1 2 2 2 0 FAD binding domain FAD_oxidored PF12831.7 EXF82863.1 - 0.047 13.0 1.3 0.087 12.2 1.3 1.5 1 1 0 1 1 1 0 FAD dependent oxidoreductase Amino_oxidase PF01593.24 EXF82863.1 - 0.077 12.3 0.0 2.5 7.3 0.0 2.4 3 0 0 3 3 3 0 Flavin containing amine oxidoreductase DUF4200 PF13863.6 EXF82863.1 - 0.1 13.0 0.4 0.17 12.3 0.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) NAD_binding_9 PF13454.6 EXF82863.1 - 0.12 12.4 1.0 7.1 6.6 0.2 2.3 2 0 0 2 2 2 0 FAD-NAD(P)-binding Thi4 PF01946.17 EXF82863.1 - 0.17 11.1 0.2 0.38 9.9 0.2 1.5 1 0 0 1 1 1 0 Thi4 family F_bP_aldolase PF01116.20 EXF82864.1 - 1.7e-86 290.2 0.1 1.9e-86 290.0 0.1 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II NAD_binding_11 PF14833.6 EXF82865.1 - 4e-38 130.4 0.1 4.5e-25 88.3 0.0 2.6 2 1 0 2 2 2 2 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase NAD_binding_2 PF03446.15 EXF82865.1 - 6.3e-32 110.9 0.6 1.2e-31 110.1 0.6 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 EXF82865.1 - 0.00021 21.8 0.4 0.0029 18.1 0.1 2.9 2 1 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent 3HCDH_N PF02737.18 EXF82865.1 - 0.01 15.7 0.1 0.04 13.8 0.2 1.9 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 EXF82865.1 - 0.037 13.4 0.0 0.067 12.6 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain YL1 PF05764.13 EXF82866.1 - 0.00075 19.7 0.7 0.00075 19.7 0.7 1.1 1 0 0 1 1 1 1 YL1 nuclear protein GAGA_bind PF06217.12 EXF82866.1 - 0.03 14.6 1.2 0.035 14.4 1.2 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family MecA PF05389.12 EXF82866.1 - 0.073 12.7 0.6 0.097 12.3 0.6 1.1 1 0 0 1 1 1 0 Negative regulator of genetic competence (MecA) PBP1_TM PF14812.6 EXF82866.1 - 0.18 12.2 4.3 0.28 11.6 4.3 1.3 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Epimerase PF01370.21 EXF82867.1 - 3.3e-07 30.0 0.0 4.8e-07 29.5 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 EXF82867.1 - 0.00012 21.3 0.0 0.35 10.0 0.0 2.1 2 0 0 2 2 2 2 Male sterility protein 3Beta_HSD PF01073.19 EXF82867.1 - 0.12 11.4 0.4 0.34 9.9 0.3 1.9 1 1 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Peptidase_C24 PF03510.14 EXF82868.1 - 0.12 12.9 0.0 0.13 12.8 0.0 1.1 1 0 0 1 1 1 0 2C endopeptidase (C24) cysteine protease family Acetyltransf_1 PF00583.25 EXF82869.1 - 1.7e-11 44.4 0.0 7.1e-11 42.4 0.0 1.9 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EXF82869.1 - 8.7e-10 38.9 0.0 8.6e-09 35.7 0.0 2.2 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EXF82869.1 - 1.1e-09 38.4 0.0 4.3e-09 36.4 0.0 2.0 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EXF82869.1 - 3.2e-05 24.0 0.0 9.3e-05 22.5 0.0 1.9 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EXF82869.1 - 3.6e-05 23.6 0.0 7.3e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.6 EXF82869.1 - 0.015 15.4 0.0 0.1 12.7 0.0 2.3 2 0 0 2 2 2 0 GCN5-related N-acetyl-transferase Acetyltransf_3 PF13302.7 EXF82869.1 - 0.14 12.9 0.0 9.6 6.9 0.0 2.8 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain DUF3669 PF12417.8 EXF82870.1 - 8.3e-23 80.4 0.1 1.9e-22 79.2 0.1 1.6 1 0 0 1 1 1 1 Zinc finger protein TRI12 PF06609.13 EXF82871.1 - 4.9e-50 170.5 23.9 6.6e-50 170.1 23.9 1.0 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_1 PF07690.16 EXF82871.1 - 3.8e-25 88.6 58.6 4.5e-23 81.7 58.3 3.0 2 1 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF82871.1 - 4.5e-08 32.4 15.1 4.5e-08 32.4 15.1 3.6 4 0 0 4 4 4 1 Sugar (and other) transporter DUF4516 PF14990.6 EXF82871.1 - 2.7 7.8 4.9 7.5 6.4 0.5 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4516) SKG6 PF08693.10 EXF82872.1 - 1.1e-07 31.2 0.2 1.9e-07 30.4 0.2 1.4 1 0 0 1 1 1 1 Transmembrane alpha-helix domain DUF4448 PF14610.6 EXF82872.1 - 0.0059 16.4 0.0 0.0099 15.7 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) Rax2 PF12768.7 EXF82872.1 - 0.0069 15.9 0.0 0.012 15.1 0.0 1.3 1 0 0 1 1 1 1 Cortical protein marker for cell polarity SdrD_B PF17210.3 EXF82872.1 - 0.0087 16.3 0.4 0.022 15.0 0.1 1.9 1 1 0 1 1 1 1 SdrD B-like domain VSP PF03302.13 EXF82872.1 - 0.019 13.8 5.3 0.03 13.2 5.3 1.2 1 0 0 1 1 1 0 Giardia variant-specific surface protein Botulinum_HA-17 PF05588.11 EXF82872.1 - 0.073 13.2 0.0 0.12 12.5 0.0 1.2 1 0 0 1 1 1 0 Clostridium botulinum HA-17 domain GDE_C PF06202.14 EXF82874.1 - 2e-06 27.0 0.5 3.8e-06 26.1 0.5 1.3 1 0 0 1 1 1 1 Amylo-alpha-1,6-glucosidase Glyco_hydro_63 PF03200.16 EXF82874.1 - 0.00096 18.0 3.4 0.02 13.6 3.4 2.0 1 1 0 1 1 1 1 Glycosyl hydrolase family 63 C-terminal domain DUF4788 PF16032.5 EXF82875.1 - 0.079 11.9 0.0 0.081 11.9 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4788) Na_H_Exchanger PF00999.21 EXF82876.1 - 2.7e-39 135.0 12.5 3.5e-39 134.7 12.5 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family YrhC PF14143.6 EXF82876.1 - 0.013 15.5 0.0 0.013 15.5 0.0 3.1 4 0 0 4 4 4 0 YrhC-like protein MpPF26 PF07666.11 EXF82876.1 - 0.085 13.0 2.8 0.43 10.7 0.1 2.7 2 0 0 2 2 2 0 M penetrans paralogue family 26 Ank_2 PF12796.7 EXF82877.1 - 6.4e-44 148.4 11.5 4.6e-13 49.6 0.0 6.5 2 2 5 7 7 7 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EXF82877.1 - 1.2e-36 124.5 5.6 3.4e-09 37.1 0.0 10.0 5 2 5 10 10 10 6 Ankyrin repeats (many copies) Ank PF00023.30 EXF82877.1 - 5.5e-33 112.0 2.6 1.3e-07 31.7 0.0 9.8 10 1 0 10 10 10 6 Ankyrin repeat Ank_3 PF13606.6 EXF82877.1 - 4e-26 88.2 2.7 0.00018 21.7 0.0 9.8 10 0 0 10 10 10 4 Ankyrin repeat Ank_5 PF13857.6 EXF82877.1 - 5.6e-24 83.9 1.5 7.4e-05 23.0 0.0 6.9 4 3 2 6 6 6 5 Ankyrin repeats (many copies) PNP_UDP_1 PF01048.20 EXF82877.1 - 3.1e-10 39.7 0.0 6.6e-10 38.6 0.0 1.6 1 1 0 1 1 1 1 Phosphorylase superfamily NACHT PF05729.12 EXF82877.1 - 0.0062 16.5 0.0 0.017 15.0 0.0 1.7 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 EXF82877.1 - 0.066 13.5 0.0 0.57 10.5 0.0 2.5 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EXF82877.1 - 0.11 12.0 0.0 0.65 9.5 0.0 2.1 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_16 PF13191.6 EXF82877.1 - 0.12 12.7 0.0 0.7 10.3 0.0 2.4 1 0 0 1 1 1 0 AAA ATPase domain CbtA PF09490.10 EXF82878.1 - 0.0003 20.6 0.2 0.00044 20.1 0.2 1.2 1 0 0 1 1 1 1 Probable cobalt transporter subunit (CbtA) LapA_dom PF06305.11 EXF82878.1 - 0.014 15.2 0.1 0.035 13.9 0.1 1.6 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain PBP1_TM PF14812.6 EXF82878.1 - 0.054 13.9 0.1 0.079 13.3 0.1 1.2 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF1308 PF07000.11 EXF82879.1 - 2.9e-07 30.6 0.0 1.6e-06 28.1 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF1308) DUF5614 PF18474.1 EXF82879.1 - 0.012 15.0 0.0 0.026 13.9 0.0 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5614) DUF1688 PF07958.11 EXF82880.1 - 7.7e-182 604.7 0.0 9e-182 604.5 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1688) 60KD_IMP PF02096.20 EXF82882.1 - 1.5e-21 77.0 0.6 2.4e-21 76.3 0.6 1.3 1 0 0 1 1 1 1 60Kd inner membrane protein FAP PF07174.11 EXF82882.1 - 0.37 10.2 20.6 0.17 11.3 12.1 2.2 2 0 0 2 2 2 0 Fibronectin-attachment protein (FAP) HemY_N PF07219.13 EXF82882.1 - 2.9 8.1 6.9 20 5.4 0.3 2.5 2 0 0 2 2 2 0 HemY protein N-terminus TOM13 PF08219.11 EXF82883.1 - 3.7e-37 126.2 0.0 4.8e-37 125.8 0.0 1.1 1 0 0 1 1 1 1 Outer membrane protein TOM13 SEP PF08059.13 EXF82884.1 - 2.4e-23 82.5 0.0 4.8e-23 81.5 0.0 1.5 1 0 0 1 1 1 1 SEP domain UBX PF00789.20 EXF82884.1 - 6.7e-11 42.2 0.0 1.1e-10 41.6 0.0 1.3 1 0 0 1 1 1 1 UBX domain UBA_4 PF14555.6 EXF82884.1 - 2.2e-10 40.2 0.0 4e-10 39.4 0.0 1.4 1 0 0 1 1 1 1 UBA-like domain TAP_C PF03943.13 EXF82884.1 - 0.0014 18.3 0.0 0.0022 17.6 0.0 1.3 1 0 0 1 1 1 1 TAP C-terminal domain SPX PF03105.19 EXF82884.1 - 0.65 9.9 2.6 1.3 8.9 2.6 1.6 1 1 0 1 1 1 0 SPX domain Gtr1_RagA PF04670.12 EXF82885.1 - 2.8e-93 311.5 0.0 3.7e-93 311.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Roc PF08477.13 EXF82885.1 - 1.2e-07 31.9 0.0 2.3e-07 31.1 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EXF82885.1 - 1.4e-07 31.3 0.0 2.8e-07 30.3 0.0 1.5 1 0 0 1 1 1 1 Ras family MMR_HSR1 PF01926.23 EXF82885.1 - 2.4e-07 30.8 0.0 4.1e-07 30.1 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Arf PF00025.21 EXF82885.1 - 2.4e-06 27.1 0.0 3.6e-06 26.5 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 EXF82885.1 - 0.0025 17.0 3.5 1.1 8.4 0.6 2.9 2 1 1 3 3 3 2 G-protein alpha subunit ABC_tran PF00005.27 EXF82885.1 - 0.0035 17.8 0.1 0.016 15.7 0.0 2.0 2 1 0 2 2 2 1 ABC transporter AAA_29 PF13555.6 EXF82885.1 - 0.0039 16.9 0.9 0.054 13.2 0.2 2.3 2 0 0 2 2 2 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EXF82885.1 - 0.014 15.3 0.3 0.27 11.1 0.1 2.3 2 0 0 2 2 2 0 RsgA GTPase DUF815 PF05673.13 EXF82885.1 - 0.02 14.1 0.0 0.044 13.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_7 PF12775.7 EXF82885.1 - 0.035 13.6 0.0 0.44 10.0 0.0 2.2 2 0 0 2 2 2 0 P-loop containing dynein motor region zf-C2H2 PF00096.26 EXF82886.1 - 0.55 10.8 6.5 2.3 8.8 0.3 4.0 5 0 0 5 5 5 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EXF82886.1 - 0.58 11.2 8.7 0.63 11.0 0.3 3.4 3 0 0 3 3 3 0 C2H2-type zinc finger DUF1295 PF06966.12 EXF82887.1 - 3.9e-31 108.4 0.1 5.7e-31 107.8 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) ICMT PF04140.14 EXF82887.1 - 0.00044 20.6 0.0 0.00091 19.6 0.0 1.5 1 0 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family Aspzincin_M35 PF14521.6 EXF82887.1 - 0.0013 19.2 0.2 91 3.6 0.0 5.5 4 2 3 7 7 7 0 Lysine-specific metallo-endopeptidase Steroid_dh PF02544.16 EXF82887.1 - 0.0017 18.3 0.0 0.0032 17.5 0.0 1.3 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF2062 PF09835.9 EXF82887.1 - 0.015 15.2 0.7 0.29 11.0 0.3 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2062) PEMT PF04191.13 EXF82887.1 - 0.13 12.7 0.0 0.28 11.6 0.0 1.5 1 0 0 1 1 1 0 Phospholipid methyltransferase ERG4_ERG24 PF01222.17 EXF82887.1 - 0.15 10.8 0.0 0.22 10.2 0.0 1.2 1 0 0 1 1 1 0 Ergosterol biosynthesis ERG4/ERG24 family Pentaxin PF00354.17 EXF82887.1 - 9.9 5.8 9.6 1e+02 2.5 0.0 5.1 3 2 3 6 6 6 0 Pentaxin family AA_permease_2 PF13520.6 EXF82889.1 - 8.1e-59 199.5 46.9 9.4e-59 199.3 46.9 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EXF82889.1 - 1.3e-23 83.4 38.2 1.7e-23 83.0 38.2 1.0 1 0 0 1 1 1 1 Amino acid permease Glucosamine_iso PF01182.20 EXF82890.1 - 1.4e-24 87.2 0.0 2.1e-24 86.7 0.0 1.2 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase FAD_binding_8 PF08022.12 EXF82890.1 - 0.038 14.1 0.0 0.074 13.1 0.0 1.4 1 0 0 1 1 1 0 FAD-binding domain Hexokinase_2 PF03727.16 EXF82892.1 - 3.7e-69 232.8 0.0 3.3e-52 177.3 0.0 2.2 2 0 0 2 2 2 2 Hexokinase Hexokinase_1 PF00349.21 EXF82892.1 - 1.9e-64 217.2 0.0 2.9e-64 216.7 0.0 1.3 1 0 0 1 1 1 1 Hexokinase Mo-co_dimer PF03404.16 EXF82893.1 - 0.069 13.2 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 Mo-co oxidoreductase dimerisation domain Alginate_lyase PF05426.12 EXF82894.1 - 4.8e-07 29.6 4.4 2e-06 27.6 4.4 1.9 1 1 0 1 1 1 1 Alginate lyase Alginate_lyase PF05426.12 EXF82895.1 - 2.7e-10 40.2 6.9 6.5e-10 39.0 6.9 1.5 1 1 0 1 1 1 1 Alginate lyase Amino_oxidase PF01593.24 EXF82896.1 - 4.5e-37 128.4 0.0 6e-37 128.0 0.0 1.0 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EXF82896.1 - 6.8e-09 35.8 0.0 2.7e-08 33.9 0.0 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EXF82896.1 - 1.3e-05 24.6 0.0 0.0042 16.3 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EXF82896.1 - 0.0018 18.8 0.2 0.012 16.2 0.1 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EXF82896.1 - 0.034 13.7 3.7 0.31 10.6 3.7 2.3 1 1 0 1 1 1 0 FAD dependent oxidoreductase Amidase PF01425.21 EXF82897.1 - 2e-25 89.7 0.4 9.3e-25 87.5 0.1 1.9 2 0 0 2 2 2 1 Amidase Epimerase PF01370.21 EXF82898.1 - 9.1e-12 45.0 0.1 2e-11 43.8 0.1 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 EXF82898.1 - 1.2e-05 25.0 0.1 7.2e-05 22.5 0.0 1.9 2 0 0 2 2 2 1 NmrA-like family NAD_binding_10 PF13460.6 EXF82898.1 - 0.00078 19.4 0.0 0.0012 18.8 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 EXF82898.1 - 0.0025 17.3 0.0 0.03 13.7 0.0 2.1 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase adh_short PF00106.25 EXF82898.1 - 0.0062 16.0 0.1 0.011 15.2 0.1 1.4 1 0 0 1 1 1 1 short chain dehydrogenase Cu_bind_like PF02298.17 EXF82899.1 - 0.021 14.8 0.0 0.041 13.9 0.0 1.4 1 0 0 1 1 1 0 Plastocyanin-like domain ADH_N PF08240.12 EXF82900.1 - 2.8e-08 33.6 0.0 4.8e-08 32.8 0.0 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EXF82900.1 - 3.2e-08 33.6 0.2 6.7e-08 32.6 0.0 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EXF82900.1 - 0.0003 21.9 0.0 0.00056 21.0 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Epimerase PF01370.21 EXF82900.1 - 0.086 12.3 0.0 0.12 11.8 0.0 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family NmrA PF05368.13 EXF82901.1 - 1.5e-20 73.7 0.0 2.2e-20 73.2 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EXF82901.1 - 1.4e-15 57.7 0.0 2.3e-15 56.9 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EXF82901.1 - 5.8e-08 32.5 0.7 4e-05 23.2 0.4 2.8 2 1 0 2 2 2 2 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EXF82901.1 - 0.00067 19.1 0.3 0.067 12.6 0.0 2.1 2 0 0 2 2 2 2 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 EXF82901.1 - 0.0023 17.1 0.2 0.0051 16.0 0.1 1.6 2 0 0 2 2 2 1 RmlD substrate binding domain F420_oxidored PF03807.17 EXF82901.1 - 0.01 16.4 0.1 0.023 15.3 0.1 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent TrkA_N PF02254.18 EXF82901.1 - 0.027 14.7 0.0 0.048 13.9 0.0 1.4 1 0 0 1 1 1 0 TrkA-N domain adh_short PF00106.25 EXF82901.1 - 0.087 12.3 0.1 0.13 11.7 0.1 1.3 1 0 0 1 1 1 0 short chain dehydrogenase DapB_N PF01113.20 EXF82901.1 - 0.093 12.9 0.0 0.15 12.2 0.0 1.4 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus DUF4711 PF15829.5 EXF82905.1 - 0.047 13.6 0.0 0.065 13.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4711) HhH-GPD PF00730.25 EXF82907.1 - 2.8e-08 34.2 0.0 1.2e-07 32.1 0.0 2.3 1 1 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 EXF82907.1 - 0.028 14.3 0.0 0.085 12.8 0.0 1.9 1 0 0 1 1 1 0 Helix-hairpin-helix motif zf-PHD-like PF15446.6 EXF82907.1 - 0.051 13.2 0.5 0.051 13.2 0.5 2.4 2 0 0 2 2 2 0 PHD/FYVE-zinc-finger like domain DMAP1 PF05499.12 EXF82907.1 - 0.16 11.8 2.0 0.36 10.7 2.0 1.6 1 0 0 1 1 1 0 DNA methyltransferase 1-associated protein 1 (DMAP1) Sugar_tr PF00083.24 EXF82908.1 - 7e-60 203.2 17.9 8.3e-60 202.9 17.9 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF82908.1 - 4.6e-19 68.6 35.6 1.3e-16 60.5 15.6 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EXF82908.1 - 0.002 16.8 23.8 0.026 13.1 12.5 3.0 2 1 1 3 3 3 3 MFS/sugar transport protein MFS_1 PF07690.16 EXF82909.1 - 6.7e-49 166.7 50.4 6.7e-49 166.7 50.4 1.8 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EXF82909.1 - 6.1e-20 71.2 20.4 7.5e-18 64.3 19.3 2.3 2 1 0 2 2 2 2 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EXF82909.1 - 2.2e-16 59.8 7.1 2.2e-16 59.8 7.1 2.3 2 0 0 2 2 2 2 Sugar (and other) transporter Kinocilin PF15033.6 EXF82909.1 - 0.3 10.7 11.5 0.46 10.1 0.6 3.4 4 0 0 4 4 4 0 Kinocilin protein OATP PF03137.20 EXF82909.1 - 8.7 4.5 36.3 0.054 11.8 5.5 4.2 2 2 2 4 4 4 0 Organic Anion Transporter Polypeptide (OATP) family COesterase PF00135.28 EXF82910.1 - 5e-64 217.0 0.0 6.3e-64 216.7 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EXF82910.1 - 5.5e-12 46.0 0.8 8.2e-07 29.1 0.1 2.4 2 0 0 2 2 2 2 alpha/beta hydrolase fold Esterase PF00756.20 EXF82910.1 - 0.00054 19.7 0.7 0.0015 18.2 0.7 1.6 1 1 0 1 1 1 1 Putative esterase Peptidase_S9 PF00326.21 EXF82910.1 - 0.013 15.0 0.1 0.025 14.0 0.1 1.5 1 0 0 1 1 1 0 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 EXF82910.1 - 0.024 15.2 3.7 0.024 15.2 3.7 2.3 2 1 0 2 2 2 0 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EXF82910.1 - 0.043 13.1 0.0 0.1 11.8 0.0 1.6 1 1 0 1 1 1 0 Serine aminopeptidase, S33 Fungal_trans PF04082.18 EXF82911.1 - 1.2e-09 37.6 0.0 6.2e-09 35.3 0.0 2.0 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF82911.1 - 0.00014 21.9 5.2 0.00022 21.3 5.2 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SPX PF03105.19 EXF82911.1 - 2.8 7.7 5.1 2.2 8.1 1.2 2.0 2 0 0 2 2 2 0 SPX domain AflR PF08493.10 EXF82911.1 - 6.7 6.1 8.7 12 5.3 8.7 1.4 1 0 0 1 1 1 0 Aflatoxin regulatory protein VIT PF08487.10 EXF82912.1 - 6.2e-36 123.0 0.2 1.2e-35 122.1 0.2 1.5 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VWA_3 PF13768.6 EXF82912.1 - 3.6e-25 88.7 0.0 6.8e-25 87.8 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VIT_2 PF13757.6 EXF82912.1 - 8.3e-13 48.0 0.2 1.7e-12 47.0 0.2 1.5 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VWA PF00092.28 EXF82912.1 - 1.8e-09 38.1 0.0 3.3e-09 37.2 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 EXF82912.1 - 5.6e-09 36.6 0.0 4.6e-08 33.7 0.0 2.4 2 0 0 2 2 2 1 von Willebrand factor type A domain Nucleoporin_FG PF13634.6 EXF82912.1 - 6e-08 33.4 58.3 8.7e-05 23.3 23.6 4.7 2 1 2 4 4 4 3 Nucleoporin FG repeat region VWA_CoxE PF05762.14 EXF82912.1 - 0.0033 16.8 0.0 0.0078 15.6 0.0 1.5 1 1 0 1 1 1 1 VWA domain containing CoxE-like protein DUF1655 PF07868.11 EXF82912.1 - 0.18 11.9 0.0 0.42 10.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1655) Acetyltransf_1 PF00583.25 EXF82913.1 - 1.7e-08 34.7 0.0 4.2e-08 33.4 0.0 1.9 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EXF82913.1 - 1.8e-07 31.5 0.0 2.8e-07 30.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EXF82913.1 - 0.00011 22.1 0.0 0.00085 19.3 0.0 2.0 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_13 PF13880.6 EXF82913.1 - 0.0055 16.7 0.0 0.011 15.7 0.0 1.4 1 0 0 1 1 1 1 ESCO1/2 acetyl-transferase FR47 PF08445.10 EXF82913.1 - 0.014 15.4 0.1 0.045 13.7 0.1 1.8 1 1 0 1 1 1 0 FR47-like protein FAD-oxidase_C PF02913.19 EXF82914.1 - 7e-59 199.5 0.0 1e-58 198.9 0.0 1.3 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 EXF82914.1 - 2.3e-37 127.8 0.0 4.9e-37 126.8 0.0 1.6 1 0 0 1 1 1 1 FAD binding domain SepSecS PF05889.13 EXF82914.1 - 0.01 14.5 0.1 0.016 13.9 0.1 1.2 1 0 0 1 1 1 0 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS ANF_receptor PF01094.28 EXF82914.1 - 0.064 12.3 0.0 0.097 11.8 0.0 1.2 1 0 0 1 1 1 0 Receptor family ligand binding region EHN PF06441.12 EXF82916.1 - 1.8e-30 105.5 0.4 3.2e-30 104.7 0.4 1.4 1 0 0 1 1 1 1 Epoxide hydrolase N terminus Abhydrolase_1 PF00561.20 EXF82916.1 - 1.4e-07 31.4 0.1 3.6e-07 30.1 0.0 1.6 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EXF82916.1 - 0.015 15.9 2.0 0.039 14.5 2.0 1.8 1 1 0 1 1 1 0 Alpha/beta hydrolase family adh_short PF00106.25 EXF82918.1 - 2.3e-29 102.3 0.0 5.1e-29 101.1 0.0 1.5 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF82918.1 - 8.3e-23 81.2 0.0 2.4e-22 79.6 0.0 1.6 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 EXF82918.1 - 0.0014 18.2 0.0 0.0021 17.5 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family KR PF08659.10 EXF82918.1 - 0.005 16.8 0.8 0.025 14.5 0.1 2.3 2 1 0 2 2 2 1 KR domain Eno-Rase_NADH_b PF12242.8 EXF82918.1 - 0.11 12.3 0.0 0.21 11.4 0.0 1.4 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase NMD3 PF04981.13 EXF82919.1 - 0.024 14.1 1.2 0.028 13.9 1.2 1.1 1 0 0 1 1 1 0 NMD3 family ZZ PF00569.17 EXF82919.1 - 0.027 14.3 5.8 0.042 13.7 5.8 1.3 1 0 0 1 1 1 0 Zinc finger, ZZ type zf-C3HC4_3 PF13920.6 EXF82919.1 - 0.083 12.8 5.1 0.14 12.1 5.1 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF2797 PF10977.8 EXF82919.1 - 0.47 10.3 4.5 0.73 9.7 4.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2797) Patatin PF01734.22 EXF82920.1 - 1.6e-22 80.7 0.0 2.8e-22 79.9 0.0 1.4 1 0 0 1 1 1 1 Patatin-like phospholipase zf-RING_UBOX PF13445.6 EXF82920.1 - 0.01 15.8 7.1 0.033 14.2 7.1 1.9 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4 PF00097.25 EXF82920.1 - 0.013 15.4 5.9 0.061 13.2 5.3 2.2 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EXF82920.1 - 0.027 14.3 5.3 0.073 12.9 5.3 1.7 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 EXF82920.1 - 0.069 13.3 5.0 0.16 12.2 0.6 2.6 1 1 1 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 EXF82920.1 - 0.1 13.0 5.9 0.29 11.5 5.9 1.8 1 0 0 1 1 1 0 Ring finger domain zf-RING_5 PF14634.6 EXF82920.1 - 0.11 12.5 6.4 0.29 11.1 6.4 1.7 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EXF82920.1 - 0.21 11.5 5.8 0.46 10.4 5.8 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EXF82920.1 - 7.7 6.4 7.4 40 4.2 6.6 2.5 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF1275 PF06912.11 EXF82921.1 - 2.3e-48 164.7 15.5 2.7e-48 164.4 15.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1275) Cupin_1 PF00190.22 EXF82922.1 - 5.8e-38 129.9 0.0 1.1e-19 70.6 0.0 2.1 2 0 0 2 2 2 2 Cupin Cupin_2 PF07883.11 EXF82922.1 - 3e-26 90.9 0.6 6.4e-13 48.2 0.1 2.3 2 0 0 2 2 2 2 Cupin domain Cupin_3 PF05899.12 EXF82922.1 - 1e-08 34.7 0.0 0.00034 20.3 0.0 2.6 2 0 0 2 2 2 2 Protein of unknown function (DUF861) AraC_binding PF02311.19 EXF82922.1 - 3.1e-07 30.4 0.2 0.00067 19.6 0.0 2.4 2 0 0 2 2 2 2 AraC-like ligand binding domain MannoseP_isomer PF01050.18 EXF82922.1 - 0.00048 20.1 0.0 0.024 14.5 0.0 2.2 2 0 0 2 2 2 1 Mannose-6-phosphate isomerase ARD PF03079.14 EXF82922.1 - 0.008 16.4 0.3 2.8 8.1 0.0 2.4 2 0 0 2 2 2 2 ARD/ARD' family 3-HAO PF06052.12 EXF82922.1 - 0.017 14.8 0.0 0.18 11.4 0.0 2.2 2 0 0 2 2 2 0 3-hydroxyanthranilic acid dioxygenase Cupin_7 PF12973.7 EXF82922.1 - 0.13 12.2 0.4 1.3 8.9 0.1 2.6 2 1 0 2 2 2 0 ChrR Cupin-like domain DUF3140 PF11338.8 EXF82923.1 - 6.1e-35 119.5 2.3 6.1e-35 119.5 2.3 3.4 2 1 0 2 2 2 1 Protein of unknown function (DUF3140) Hva1_TUDOR PF11160.8 EXF82923.1 - 1.1e-14 54.4 1.9 1.1e-14 54.4 1.9 3.1 2 0 0 2 2 2 1 Hypervirulence associated proteins TUDOR domain CDC27 PF09507.10 EXF82923.1 - 1.2 8.4 45.4 1.7 7.9 45.4 1.3 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 CCDC71L PF15374.6 EXF82923.1 - 9.1 5.4 20.2 13 4.9 20.2 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 71L Lipocalin_2 PF08212.12 EXF82924.1 - 8e-19 68.0 0.0 9.6e-19 67.7 0.0 1.1 1 0 0 1 1 1 1 Lipocalin-like domain Lipocalin PF00061.23 EXF82924.1 - 0.0033 17.6 0.0 0.012 15.8 0.0 1.8 1 1 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family DUF5546 PF17700.1 EXF82924.1 - 0.034 14.5 0.3 0.1 13.0 0.1 1.9 1 1 1 2 2 2 0 Family of unknown function (DUF5546) Isochorismatase PF00857.20 EXF82925.1 - 1.1e-38 133.1 0.0 1.3e-38 132.9 0.0 1.0 1 0 0 1 1 1 1 Isochorismatase family Peptidase_M28 PF04389.17 EXF82926.1 - 1.2e-24 87.1 0.0 5.3e-24 85.0 0.0 1.9 2 0 0 2 2 2 1 Peptidase family M28 Peptidase_M20 PF01546.28 EXF82926.1 - 6.6e-09 35.8 0.3 4.5e-08 33.0 0.3 2.1 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 Cnl2_NKP2 PF09447.10 EXF82926.1 - 0.029 14.5 0.7 0.32 11.2 0.2 2.3 2 0 0 2 2 2 0 Cnl2/NKP2 family protein Bac_rhamnosid6H PF17389.2 EXF82927.1 - 1.8e-125 418.7 0.0 2.4e-125 418.3 0.0 1.1 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain Bac_rhamnosid_N PF08531.10 EXF82927.1 - 3.3e-50 170.2 0.0 5.8e-50 169.5 0.0 1.3 1 0 0 1 1 1 1 Alpha-L-rhamnosidase N-terminal domain Bac_rhamnosid PF05592.11 EXF82927.1 - 4.8e-27 93.9 0.0 8.9e-26 89.9 0.0 2.3 2 0 0 2 2 2 1 Bacterial alpha-L-rhamnosidase concanavalin-like domain Bac_rhamnosid_C PF17390.2 EXF82927.1 - 6.9e-22 77.0 0.0 1.8e-21 75.7 0.0 1.7 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase C-terminal domain Fungal_trans_2 PF11951.8 EXF82928.1 - 3e-16 59.2 1.0 3e-16 59.2 1.0 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain DUF3984 PF13136.6 EXF82928.1 - 0.0025 17.3 8.3 0.0037 16.7 8.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3984) MIT PF04212.18 EXF82928.1 - 0.14 12.2 0.1 0.45 10.6 0.0 1.9 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain SOG2 PF10428.9 EXF82928.1 - 1.8 7.7 10.7 2.4 7.2 10.7 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Ndc1_Nup PF09531.10 EXF82928.1 - 3.5 6.2 9.6 1.9 7.1 6.8 1.8 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup Fungal_trans_2 PF11951.8 EXF82929.1 - 0.035 12.9 0.0 0.066 12.0 0.0 1.4 1 0 0 1 1 1 0 Fungal specific transcription factor domain Aldo_ket_red PF00248.21 EXF82930.1 - 3.2e-47 161.1 0.0 4.3e-47 160.7 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family ADH_N PF08240.12 EXF82931.1 - 4.8e-29 100.4 2.9 8.9e-29 99.6 2.9 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EXF82931.1 - 3e-12 46.7 0.0 5.3e-12 45.9 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EXF82931.1 - 0.0021 17.6 1.3 0.043 13.3 1.3 2.7 1 1 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 EXF82931.1 - 0.091 13.8 0.0 0.24 12.4 0.0 1.7 1 0 0 1 1 1 0 Zinc-binding dehydrogenase FAD_binding_4 PF01565.23 EXF82934.1 - 3.9e-23 81.7 0.5 8.3e-23 80.7 0.5 1.6 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EXF82934.1 - 3e-09 36.8 0.0 7.3e-09 35.6 0.0 1.7 1 0 0 1 1 1 1 Berberine and berberine like Peptidase_M43 PF05572.13 EXF82935.1 - 1.7e-12 47.5 0.1 3.4e-12 46.5 0.1 1.5 1 0 0 1 1 1 1 Pregnancy-associated plasma protein-A Reprolysin_5 PF13688.6 EXF82935.1 - 1.8e-05 25.0 0.3 2.9e-05 24.3 0.3 1.4 1 1 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_4 PF13583.6 EXF82935.1 - 0.00019 21.2 0.1 0.00097 18.8 0.1 1.9 2 0 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 EXF82935.1 - 0.00019 21.4 0.4 0.00032 20.7 0.4 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_3 PF13582.6 EXF82935.1 - 0.00021 21.8 0.1 0.00031 21.2 0.1 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.24 EXF82935.1 - 0.0043 16.9 0.5 0.022 14.6 0.1 2.1 2 0 0 2 2 2 1 Matrixin DUF4953 PF16313.5 EXF82935.1 - 0.4 9.9 1.5 0.63 9.2 1.5 1.2 1 0 0 1 1 1 0 Met-zincin Peptidase_M57 PF12388.8 EXF82935.1 - 5.7 6.5 5.6 31 4.1 5.4 1.9 1 1 0 1 1 1 0 Dual-action HEIGH metallo-peptidase Helo_like_N PF17111.5 EXF82936.1 - 6.7e-09 35.4 1.2 6.7e-09 35.4 1.2 1.8 2 0 0 2 2 2 1 Fungal N-terminal domain of STAND proteins TPR_12 PF13424.6 EXF82936.1 - 8.4e-06 26.0 0.5 0.02 15.2 0.0 3.7 1 1 2 3 3 3 2 Tetratricopeptide repeat SesA PF17107.5 EXF82936.1 - 0.0017 18.5 0.4 0.0046 17.2 0.2 1.9 1 1 1 2 2 2 1 N-terminal domain on NACHT_NTPase and P-loop NTPases GP70 PF17429.2 EXF82937.1 - 0.11 12.3 0.0 0.34 10.8 0.0 1.7 2 0 0 2 2 2 0 Gene product 70 CAF1A PF12253.8 EXF82941.1 - 4.2e-21 74.9 3.4 4.2e-21 74.9 3.4 3.6 2 1 0 2 2 2 1 Chromatin assembly factor 1 subunit A SprA-related PF12118.8 EXF82941.1 - 0.0011 18.2 16.6 0.0022 17.2 16.6 1.5 1 0 0 1 1 1 1 SprA-related family Presenilin PF01080.17 EXF82941.1 - 0.33 9.7 20.2 0.56 8.9 20.2 1.3 1 0 0 1 1 1 0 Presenilin RR_TM4-6 PF06459.12 EXF82941.1 - 0.34 10.7 31.7 0.019 14.8 25.1 2.3 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Hamartin PF04388.12 EXF82941.1 - 0.65 8.6 28.9 0.022 13.5 21.8 1.8 2 0 0 2 2 2 0 Hamartin protein PPP4R2 PF09184.11 EXF82941.1 - 1.2 8.6 26.4 0.19 11.3 16.5 2.6 2 0 0 2 2 2 0 PPP4R2 FAM60A PF15396.6 EXF82941.1 - 3.4 7.6 25.5 0.15 12.1 18.8 2.1 2 0 0 2 2 2 0 Protein Family FAM60A ARGLU PF15346.6 EXF82941.1 - 4.6 7.1 45.5 13 5.6 45.5 1.7 1 0 0 1 1 1 0 Arginine and glutamate-rich 1 Glyco_hydro_28 PF00295.17 EXF82942.1 - 7.6e-37 127.1 1.9 6.7e-34 117.4 0.7 2.1 2 0 0 2 2 2 2 Glycosyl hydrolases family 28 YppG PF14179.6 EXF82943.1 - 0.15 12.7 5.6 0.28 11.9 5.6 1.4 1 1 0 1 1 1 0 YppG-like protein PAF-AH_p_II PF03403.13 EXF82944.1 - 1.7e-39 135.4 0.0 2.9e-35 121.5 0.0 2.2 2 0 0 2 2 2 2 Platelet-activating factor acetylhydrolase, isoform II Chlorophyllase2 PF12740.7 EXF82944.1 - 0.00017 20.6 0.0 0.00044 19.2 0.0 1.6 2 0 0 2 2 2 1 Chlorophyllase enzyme Hydrolase_4 PF12146.8 EXF82944.1 - 0.0052 16.1 0.0 0.07 12.4 0.0 2.1 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Chlorophyllase PF07224.11 EXF82944.1 - 0.029 13.4 0.0 0.05 12.6 0.0 1.3 1 0 0 1 1 1 0 Chlorophyllase Pyr_redox_3 PF13738.6 EXF82945.1 - 1.1e-15 57.7 0.1 2.4e-14 53.3 0.0 2.4 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EXF82945.1 - 2.3e-15 56.6 0.0 9e-11 41.5 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EXF82945.1 - 8.7e-15 54.7 0.0 5.6e-10 38.9 0.0 2.3 2 0 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) FMO-like PF00743.19 EXF82945.1 - 1e-13 50.6 0.0 1.9e-13 49.7 0.0 1.4 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like DAO PF01266.24 EXF82945.1 - 5.6e-07 29.5 1.2 0.13 11.8 0.0 3.2 3 0 0 3 3 3 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EXF82945.1 - 1.1e-06 28.7 0.0 3.1e-06 27.3 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 EXF82945.1 - 0.00012 22.6 0.0 0.51 10.9 0.0 2.8 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EXF82945.1 - 0.00014 21.1 4.3 0.14 11.2 0.5 3.2 3 0 0 3 3 3 2 FAD binding domain FAD_oxidored PF12831.7 EXF82945.1 - 0.00059 19.3 0.1 0.0011 18.4 0.1 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 EXF82945.1 - 0.00066 19.0 0.1 2 7.6 0.0 3.2 3 0 0 3 3 3 1 Thi4 family NAD_binding_9 PF13454.6 EXF82945.1 - 0.0045 17.0 3.2 3 7.8 0.2 3.9 3 1 0 3 3 3 1 FAD-NAD(P)-binding Amino_oxidase PF01593.24 EXF82945.1 - 0.0065 15.8 0.4 0.34 10.1 0.0 2.7 2 1 1 3 3 3 1 Flavin containing amine oxidoreductase SnoaL_2 PF12680.7 EXF82945.1 - 0.011 16.4 0.2 0.033 14.8 0.2 1.8 1 0 0 1 1 1 0 SnoaL-like domain Shikimate_DH PF01488.20 EXF82945.1 - 0.017 15.2 0.0 0.033 14.3 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase HI0933_like PF03486.14 EXF82945.1 - 0.079 11.7 0.3 0.24 10.0 0.3 1.8 2 0 0 2 2 2 0 HI0933-like protein NAD_binding_7 PF13241.6 EXF82945.1 - 0.15 12.5 0.0 16 6.0 0.0 2.5 2 0 0 2 2 2 0 Putative NAD(P)-binding FAD_binding_3 PF01494.19 EXF82945.1 - 0.36 10.0 2.1 13 4.9 0.2 2.6 2 1 0 3 3 3 0 FAD binding domain Peptidase_M18 PF02127.15 EXF82946.1 - 3.5e-123 411.6 0.0 4.1e-123 411.4 0.0 1.0 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) EXS PF03124.14 EXF82947.1 - 1e-102 343.9 28.8 1.2e-102 343.6 28.8 1.1 1 0 0 1 1 1 1 EXS family SPX PF03105.19 EXF82947.1 - 7.3e-86 289.5 10.0 7.3e-86 289.5 10.0 2.8 2 1 0 2 2 2 1 SPX domain DUF883 PF05957.13 EXF82947.1 - 0.98 10.1 2.8 1.2 9.8 0.5 2.2 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) Methyltransf_23 PF13489.6 EXF82949.1 - 3e-23 82.5 0.0 4.2e-23 82.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF82949.1 - 1.7e-09 38.3 0.0 6.2e-09 36.5 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF82949.1 - 1.3e-08 34.8 0.0 2.3e-07 30.7 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF82949.1 - 2.5e-06 28.1 0.0 5.7e-06 26.9 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF82949.1 - 2.8e-06 28.0 0.0 2.3e-05 25.1 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 EXF82949.1 - 0.012 15.0 2.8 0.016 14.7 0.0 2.4 3 0 0 3 3 3 0 Putative methyltransferase FtsJ PF01728.19 EXF82949.1 - 0.028 14.5 0.0 0.05 13.7 0.0 1.5 1 1 0 1 1 1 0 FtsJ-like methyltransferase MTS PF05175.14 EXF82949.1 - 0.035 13.6 0.0 0.1 12.2 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase small domain PrmA PF06325.13 EXF82949.1 - 0.07 12.5 0.0 0.14 11.6 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_23 PF13489.6 EXF82950.1 - 6.8e-22 78.1 0.0 9.7e-22 77.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF82950.1 - 1.6e-09 38.3 0.0 3.9e-09 37.1 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF82950.1 - 1.7e-09 37.7 0.0 2.5e-08 33.8 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF82950.1 - 5.2e-07 30.2 0.0 1e-06 29.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF82950.1 - 1.8e-06 28.6 0.0 1.3e-05 25.8 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 EXF82950.1 - 0.025 14.0 0.0 0.048 13.1 0.0 1.4 1 0 0 1 1 1 0 Putative methyltransferase PrmA PF06325.13 EXF82950.1 - 0.041 13.3 0.0 0.063 12.7 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 EXF82950.1 - 0.067 12.7 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_2 PF00891.18 EXF82950.1 - 0.092 12.0 0.0 0.37 10.1 0.0 1.9 2 0 0 2 2 2 0 O-methyltransferase domain PCMT PF01135.19 EXF82950.1 - 0.13 12.0 0.0 1.4 8.6 0.0 2.1 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Fungal_trans_2 PF11951.8 EXF82951.1 - 2e-09 36.8 1.0 2.9e-09 36.2 1.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Peptidase_M43 PF05572.13 EXF82952.1 - 9.8e-16 58.0 0.0 1.7e-15 57.2 0.0 1.5 1 0 0 1 1 1 1 Pregnancy-associated plasma protein-A Reprolysin_3 PF13582.6 EXF82952.1 - 1.6e-05 25.4 0.1 4.1e-05 24.1 0.1 1.8 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 EXF82952.1 - 3.3e-05 24.1 5.6 0.0001 22.5 5.5 1.8 1 1 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_2 PF13574.6 EXF82952.1 - 0.0016 18.3 0.1 0.0026 17.7 0.1 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.24 EXF82952.1 - 0.0023 17.8 0.0 0.0031 17.4 0.0 1.3 1 1 0 1 1 1 1 Matrixin Reprolysin_4 PF13583.6 EXF82952.1 - 0.0027 17.4 4.9 0.008 15.8 4.9 1.8 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M54 PF07998.11 EXF82952.1 - 0.13 12.2 0.0 0.26 11.2 0.0 1.4 1 0 0 1 1 1 0 Peptidase family M54 Peptidase_M57 PF12388.8 EXF82952.1 - 1 9.0 6.8 4.4 6.8 6.8 2.2 1 1 0 1 1 1 0 Dual-action HEIGH metallo-peptidase p450 PF00067.22 EXF82953.1 - 1.7e-11 43.6 0.0 4.9e-11 42.0 0.0 1.6 2 0 0 2 2 2 1 Cytochrome P450 p450 PF00067.22 EXF82954.1 - 8.1e-49 166.6 0.0 1.1e-48 166.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Macoilin PF09726.9 EXF82955.1 - 0.4 9.2 6.3 0.67 8.4 6.3 1.4 1 0 0 1 1 1 0 Macoilin family WSC PF01822.19 EXF82957.1 - 1.2e-64 214.5 60.0 1.4e-17 63.7 11.0 4.7 4 0 0 4 4 4 4 WSC domain PQQ_3 PF13570.6 EXF82957.1 - 0.00029 21.2 7.1 0.54 10.8 0.1 5.2 3 1 0 3 3 3 2 PQQ-like domain Gryzun-like PF12742.7 EXF82957.1 - 0.082 12.9 0.0 0.17 11.9 0.0 1.5 1 0 0 1 1 1 0 Gryzun, putative Golgi trafficking Ntox5 PF15543.6 EXF82957.1 - 0.13 12.1 0.1 0.27 11.1 0.1 1.5 1 0 0 1 1 1 0 Bacterial toxin 5 ASH PF15780.5 EXF82957.1 - 2 8.7 14.0 3 8.1 0.2 5.0 4 2 0 4 4 4 0 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin PQQ PF01011.21 EXF82957.1 - 7 6.8 5.7 12 6.1 0.1 4.0 4 0 0 4 4 4 0 PQQ enzyme repeat Blt1_C PF17183.4 EXF82958.1 - 0.13 11.9 0.1 0.72 9.5 0.0 2.0 2 0 0 2 2 2 0 Get5 carboxyl domain p450 PF00067.22 EXF82960.1 - 2.9e-54 184.5 0.0 8.5e-54 183.0 0.0 1.5 1 1 0 1 1 1 1 Cytochrome P450 CBP PF12192.8 EXF82962.1 - 0.0037 17.4 0.7 0.0037 17.4 0.7 1.8 2 0 0 2 2 2 1 Fungal calcium binding protein Ribosomal_L7Ae PF01248.26 EXF82965.1 - 0.00065 19.4 0.0 0.0016 18.1 0.0 1.6 1 1 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family zf-C2H2_assoc3 PF16637.5 EXF82965.1 - 1.5 9.1 6.3 0.4 10.9 2.1 2.1 1 1 1 2 2 2 0 Putative zinc-finger between two C2H2 zinc-fingers on Patz Glyco_hydro_16 PF00722.21 EXF82966.1 - 7.8e-12 45.0 0.9 1.2e-11 44.4 0.9 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 Cthe_2159 PF14262.6 EXF82966.1 - 0.052 12.9 0.2 0.082 12.2 0.2 1.3 1 0 0 1 1 1 0 Carbohydrate-binding domain-containing protein Cthe_2159 BRCT PF00533.26 EXF82967.1 - 0.00024 21.4 0.0 0.00057 20.2 0.0 1.7 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain RTT107_BRCT_5 PF16770.5 EXF82967.1 - 0.011 15.6 0.0 0.023 14.6 0.0 1.5 1 0 0 1 1 1 0 Regulator of Ty1 transposition protein 107 BRCT domain BRCT_3 PF18428.1 EXF82967.1 - 0.06 13.4 0.0 12 6.0 0.0 2.6 2 0 0 2 2 2 0 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EXF82967.1 - 0.061 13.7 0.0 0.15 12.5 0.0 1.7 1 0 0 1 1 1 0 BRCT domain, a BRCA1 C-terminus domain CAML PF14963.6 EXF82968.1 - 0.47 10.5 2.3 0.7 10.0 2.3 1.2 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand Ndc1_Nup PF09531.10 EXF82968.1 - 9.2 4.8 8.7 9 4.8 8.7 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup ResIII PF04851.15 EXF82969.1 - 0.0018 18.3 0.0 0.0036 17.3 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DUF2235 PF09994.9 EXF82970.1 - 8e-77 258.4 0.0 1e-76 258.0 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) Glyco_hydro_115 PF15979.5 EXF82971.1 - 1.3e-129 432.5 0.4 1.3e-129 432.5 0.4 1.4 2 0 0 2 2 2 1 Glycosyl hydrolase family 115 GH115_C PF17829.1 EXF82971.1 - 1.1e-37 129.5 0.0 2.3e-37 128.5 0.0 1.6 1 0 0 1 1 1 1 Gylcosyl hydrolase family 115 C-terminal domain Glyco_hydro_18 PF00704.28 EXF82972.1 - 2.9e-14 53.5 0.0 4.6e-14 52.8 0.0 1.3 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 Fungal_trans PF04082.18 EXF82974.1 - 2.8e-41 141.3 0.5 4.8e-41 140.6 0.5 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 EXF82974.1 - 1.6e-06 28.2 12.6 0.0013 19.1 1.8 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EXF82974.1 - 6.5e-05 23.4 10.2 0.019 15.8 1.2 3.0 2 0 0 2 2 2 2 C2H2-type zinc finger zf-met PF12874.7 EXF82974.1 - 0.002 18.5 0.6 0.33 11.4 0.1 2.8 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EXF82974.1 - 0.046 14.0 1.5 0.33 11.3 0.0 2.7 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding FAD_binding_3 PF01494.19 EXF82975.1 - 5.3e-20 72.0 0.0 5.1e-13 49.0 0.0 2.1 2 0 0 2 2 2 2 FAD binding domain Trp_halogenase PF04820.14 EXF82975.1 - 5.3e-06 25.6 0.9 0.016 14.0 0.4 2.1 1 1 1 2 2 2 2 Tryptophan halogenase Lycopene_cycl PF05834.12 EXF82975.1 - 5.3e-06 25.7 0.0 8.8e-06 25.0 0.0 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_2 PF07992.14 EXF82975.1 - 5.7e-06 25.8 0.0 0.0033 16.7 0.1 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EXF82975.1 - 4.5e-05 22.3 0.9 0.018 13.7 2.4 2.1 2 0 0 2 2 2 2 HI0933-like protein NAD_binding_8 PF13450.6 EXF82975.1 - 0.00081 19.6 1.8 0.00081 19.6 1.8 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EXF82975.1 - 0.001 18.7 8.8 0.42 10.1 7.3 2.5 2 1 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EXF82975.1 - 0.003 16.7 5.7 0.0053 15.9 5.7 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.6 EXF82975.1 - 0.043 13.1 0.2 0.065 12.5 0.2 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EXF82975.1 - 0.049 14.2 1.5 0.33 11.5 1.6 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 EXF82975.1 - 0.098 11.9 0.6 13 4.9 0.6 2.2 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase Methyltransf_16 PF10294.9 EXF82975.1 - 0.11 12.2 0.4 0.18 11.5 0.0 1.5 2 0 0 2 2 2 0 Lysine methyltransferase FAD_oxidored PF12831.7 EXF82975.1 - 0.37 10.1 6.0 0.56 9.5 6.0 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase 3HCDH_N PF02737.18 EXF82975.1 - 0.44 10.4 1.9 0.76 9.6 1.9 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GIDA PF01134.22 EXF82975.1 - 2.3 7.2 5.7 3.3 6.7 5.7 1.1 1 0 0 1 1 1 0 Glucose inhibited division protein A PAN_4 PF14295.6 EXF82976.1 - 0.24 11.3 8.2 5.2 7.1 0.4 3.1 2 1 0 2 2 2 0 PAN domain Oxidored_FMN PF00724.20 EXF82977.1 - 1.7e-38 132.8 0.0 2.8e-38 132.1 0.0 1.3 1 1 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Get5_C PF18514.1 EXF82977.1 - 0.2 11.4 0.0 0.55 10.0 0.0 1.7 2 0 0 2 2 2 0 Get5 C-terminal domain ComX PF05952.12 EXF82977.1 - 0.21 11.6 0.0 0.53 10.3 0.0 1.6 1 0 0 1 1 1 0 Bacillus competence pheromone ComX Oxidored_FMN PF00724.20 EXF82978.1 - 4e-40 138.1 0.0 4.7e-40 137.9 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family MFS_1 PF07690.16 EXF82979.1 - 7e-25 87.7 36.8 6.8e-19 68.0 12.2 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily OapA_N PF08525.11 EXF82979.1 - 0.035 14.1 1.1 7 6.7 0.6 2.7 2 0 0 2 2 2 0 Opacity-associated protein A N-terminal motif FAD_binding_3 PF01494.19 EXF82980.1 - 2e-70 237.8 0.0 2.5e-70 237.5 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Phe_hydrox_dim PF07976.12 EXF82980.1 - 5.2e-20 72.1 0.0 1e-19 71.2 0.0 1.5 1 0 0 1 1 1 1 Phenol hydroxylase, C-terminal dimerisation domain HI0933_like PF03486.14 EXF82980.1 - 6.8e-05 21.7 0.0 0.0006 18.6 0.0 2.1 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox_2 PF07992.14 EXF82980.1 - 6.9e-05 22.2 0.0 0.0022 17.3 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EXF82980.1 - 9.6e-05 22.9 0.0 0.0019 18.7 0.0 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EXF82980.1 - 0.00017 21.8 0.0 0.00039 20.6 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 EXF82980.1 - 0.0039 16.5 0.0 0.0083 15.4 0.0 1.4 1 0 0 1 1 1 1 Thi4 family Lycopene_cycl PF05834.12 EXF82980.1 - 0.021 13.9 0.1 0.032 13.3 0.1 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein AlaDh_PNT_C PF01262.21 EXF82980.1 - 0.028 13.7 0.0 0.047 13.0 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain DAO PF01266.24 EXF82980.1 - 0.029 14.0 0.0 0.05 13.2 0.0 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EXF82980.1 - 0.036 13.2 0.1 0.065 12.3 0.1 1.4 1 0 0 1 1 1 0 FAD binding domain UDPG_MGDP_dh_N PF03721.14 EXF82980.1 - 0.041 13.4 0.0 0.065 12.8 0.0 1.2 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain XdhC_C PF13478.6 EXF82980.1 - 0.054 14.0 0.0 0.098 13.2 0.0 1.4 1 0 0 1 1 1 0 XdhC Rossmann domain 2-Hacid_dh_C PF02826.19 EXF82980.1 - 0.088 12.2 0.0 0.17 11.3 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain FAD_oxidored PF12831.7 EXF82980.1 - 0.12 11.7 0.0 0.27 10.5 0.0 1.5 2 0 0 2 2 2 0 FAD dependent oxidoreductase 3HCDH_N PF02737.18 EXF82980.1 - 0.14 12.0 0.0 0.26 11.2 0.0 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pyr_redox_3 PF13738.6 EXF82980.1 - 0.2 10.9 0.0 0.33 10.2 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Amidase PF01425.21 EXF82981.1 - 1.7e-108 363.5 0.0 2.5e-108 362.9 0.0 1.2 1 0 0 1 1 1 1 Amidase Polysacc_deac_1 PF01522.21 EXF82982.1 - 5.9e-17 61.7 0.0 1.2e-16 60.7 0.0 1.5 1 0 0 1 1 1 1 Polysaccharide deacetylase DUF2334 PF10096.9 EXF82982.1 - 1.9e-05 24.4 0.1 8.9e-05 22.2 0.0 2.1 2 1 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2334) p450 PF00067.22 EXF82983.1 - 3.4e-38 131.6 0.0 4.1e-38 131.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 ADH_zinc_N PF00107.26 EXF82984.1 - 2.9e-23 82.3 0.4 5.4e-23 81.4 0.4 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EXF82984.1 - 2.2e-16 61.1 0.1 4.4e-16 60.1 0.1 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EXF82984.1 - 8.4e-08 32.1 0.1 1.5e-07 31.2 0.1 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain AlaDh_PNT_C PF01262.21 EXF82984.1 - 0.0027 17.1 0.6 0.0048 16.2 0.6 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Acyl_transf_3 PF01757.22 EXF82985.1 - 1.3e-17 63.9 32.0 2e-17 63.3 32.0 1.3 1 0 0 1 1 1 1 Acyltransferase family 2OG-FeII_Oxy PF03171.20 EXF82986.1 - 1.5e-22 80.0 0.0 3.6e-22 78.7 0.0 1.6 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 EXF82986.1 - 5.4e-05 23.9 0.0 0.00013 22.7 0.0 1.6 2 0 0 2 2 2 1 non-haem dioxygenase in morphine synthesis N-terminal Ring_hydroxyl_A PF00848.19 EXF82987.1 - 1e-23 84.4 4.4 4.8e-11 43.0 2.0 2.3 1 1 1 2 2 2 2 Ring hydroxylating alpha subunit (catalytic domain) Rieske PF00355.26 EXF82987.1 - 1.6e-13 50.4 0.0 3e-13 49.5 0.0 1.4 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain NAD_binding_8 PF13450.6 EXF82989.1 - 0.00065 19.9 0.2 0.0013 18.9 0.2 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 EXF82989.1 - 0.0024 17.9 0.2 0.0045 17.0 0.1 1.5 1 1 0 1 1 1 1 FAD-NAD(P)-binding DAO PF01266.24 EXF82989.1 - 0.0025 17.5 0.2 0.0035 17.0 0.2 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 EXF82989.1 - 0.0039 16.5 0.0 0.0048 16.2 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EXF82989.1 - 0.005 16.1 0.0 0.006 15.8 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EXF82989.1 - 0.016 15.7 0.1 0.036 14.6 0.1 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EXF82989.1 - 0.12 11.6 0.1 0.21 10.8 0.1 1.3 1 0 0 1 1 1 0 Thi4 family FAD_binding_2 PF00890.24 EXF82989.1 - 0.24 10.5 0.5 0.33 10.0 0.5 1.2 1 0 0 1 1 1 0 FAD binding domain SET PF00856.28 EXF82990.1 - 1.4e-08 35.3 0.0 1.4e-07 32.0 0.0 2.1 1 1 1 2 2 2 1 SET domain FAD_binding_3 PF01494.19 EXF82991.1 - 1.4e-45 156.1 0.0 1.8e-45 155.7 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EXF82991.1 - 0.01 15.1 0.0 0.018 14.3 0.0 1.4 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Glyco_hydro_30C PF17189.4 EXF82991.1 - 0.065 13.5 0.0 7 7.0 0.0 2.5 2 0 0 2 2 2 0 Glycosyl hydrolase family 30 beta sandwich domain Pyr_redox_3 PF13738.6 EXF82991.1 - 0.24 10.6 0.1 2.1 7.5 0.3 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase COesterase PF00135.28 EXF82992.1 - 6.3e-49 167.2 0.0 1.4e-47 162.8 0.0 2.5 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EXF82992.1 - 3e-06 27.2 0.0 5.1e-06 26.5 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EXF82992.1 - 0.0072 17.0 0.5 0.016 15.9 0.4 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family COesterase PF00135.28 EXF82993.1 - 7.5e-57 193.3 0.0 9.6e-57 193.0 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EXF82993.1 - 1.7e-06 28.1 0.1 3.1e-05 23.9 0.1 2.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EXF82993.1 - 0.002 18.7 0.1 0.0044 17.7 0.0 1.6 2 0 0 2 2 2 1 Alpha/beta hydrolase family Fungal_trans PF04082.18 EXF82994.1 - 2.3e-08 33.4 3.7 0.00023 20.3 0.3 2.4 1 1 1 2 2 2 2 Fungal specific transcription factor domain zf-H2C2_2 PF13465.6 EXF82994.1 - 1.9e-07 31.2 11.2 5.2e-05 23.5 5.3 2.7 2 0 0 2 2 2 2 Zinc-finger double domain zf-C2H2 PF00096.26 EXF82994.1 - 0.0013 19.0 21.8 0.019 15.4 1.4 3.0 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EXF82994.1 - 0.074 13.9 21.4 0.093 13.6 1.1 3.1 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EXF82994.1 - 0.68 10.3 7.7 2.8 8.3 2.7 2.8 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding p450 PF00067.22 EXF82995.1 - 1.2e-74 251.8 0.0 1.3e-74 251.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 HgmA PF04209.13 EXF82996.1 - 2.2e-167 557.1 0.0 2.6e-167 556.9 0.0 1.0 1 0 0 1 1 1 1 homogentisate 1,2-dioxygenase FAD_binding_4 PF01565.23 EXF82997.1 - 3.4e-25 88.4 5.6 3.4e-25 88.4 5.6 1.5 2 0 0 2 2 2 1 FAD binding domain BBE PF08031.12 EXF82997.1 - 0.0021 18.1 0.0 0.0055 16.8 0.0 1.7 1 0 0 1 1 1 1 Berberine and berberine like AAA_16 PF13191.6 EXF82998.1 - 8.2e-07 29.6 0.2 7.9e-06 26.4 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain NACHT PF05729.12 EXF82998.1 - 6.7e-05 22.9 0.0 0.00016 21.6 0.0 1.6 1 0 0 1 1 1 1 NACHT domain Ank_4 PF13637.6 EXF82998.1 - 0.0026 18.3 0.1 0.054 14.1 0.0 3.0 3 1 0 3 3 3 1 Ankyrin repeats (many copies) AAA_22 PF13401.6 EXF82998.1 - 0.009 16.3 0.0 0.094 13.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 EXF82998.1 - 0.011 15.3 0.1 0.14 11.6 0.0 2.6 3 0 0 3 3 3 0 P-loop containing dynein motor region Sigma54_activat PF00158.26 EXF82998.1 - 0.15 11.8 0.0 0.28 10.9 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain Enterotoxin_a PF01375.17 EXF82999.1 - 7.1e-48 163.4 1.4 8.2e-48 163.2 1.4 1.0 1 0 0 1 1 1 1 Heat-labile enterotoxin alpha chain DUF4419 PF14388.6 EXF83001.1 - 5.3e-18 65.5 0.0 6.5e-18 65.2 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4419) GcpE PF04551.14 EXF83001.1 - 0.02 14.0 0.0 0.026 13.6 0.0 1.1 1 0 0 1 1 1 0 GcpE protein Orbi_NS1 PF01718.16 EXF83001.1 - 0.19 10.2 0.0 0.21 10.0 0.0 1.0 1 0 0 1 1 1 0 Orbivirus non-structural protein NS1, or hydrophobic tubular protein ADH_zinc_N PF00107.26 EXF83006.1 - 6.9e-21 74.6 0.4 6.9e-21 74.6 0.4 2.6 4 0 0 4 4 4 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EXF83006.1 - 1.8e-20 72.9 2.9 3e-20 72.1 2.9 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 EXF83006.1 - 9.1e-05 23.5 1.3 0.00014 22.9 0.7 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Lipase_GDSL_2 PF13472.6 EXF83007.1 - 2.7e-11 44.2 0.4 3.5e-11 43.8 0.4 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EXF83007.1 - 0.0005 20.1 0.0 0.00064 19.8 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lactamase_B PF00753.27 EXF83008.1 - 1.8e-19 70.6 4.4 3.8e-19 69.5 4.4 1.5 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EXF83008.1 - 1.6e-06 27.8 0.0 2.5e-06 27.1 0.0 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain MDH PF02315.16 EXF83008.1 - 0.12 12.4 0.0 0.25 11.4 0.0 1.4 1 0 0 1 1 1 0 Methanol dehydrogenase beta subunit FAD_binding_4 PF01565.23 EXF83009.1 - 7.2e-23 80.9 3.1 8.5e-23 80.6 1.0 2.2 1 1 1 2 2 2 1 FAD binding domain BBE PF08031.12 EXF83009.1 - 5e-07 29.7 0.0 9.6e-07 28.8 0.0 1.5 1 0 0 1 1 1 1 Berberine and berberine like SelK_SelG PF10961.8 EXF83010.1 - 0.11 13.1 0.1 0.11 13.1 0.1 2.7 3 0 0 3 3 3 0 Selenoprotein SelK_SelG Cu_amine_oxid PF01179.20 EXF83012.1 - 1.6e-165 551.0 0.0 2.1e-165 550.6 0.0 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN2 PF02727.16 EXF83012.1 - 2.7e-11 43.5 0.2 4.7e-11 42.8 0.2 1.4 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain Cu_amine_oxidN3 PF02728.16 EXF83012.1 - 0.0019 18.6 0.0 0.011 16.1 0.0 2.1 2 0 0 2 2 2 1 Copper amine oxidase, N3 domain Peptidase_M28 PF04389.17 EXF83013.1 - 6.6e-40 136.9 0.0 9.9e-40 136.3 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 EXF83013.1 - 3.7e-11 43.1 0.6 2.6e-10 40.4 0.4 2.3 2 1 0 2 2 2 1 Peptidase family M20/M25/M40 Nicastrin PF05450.15 EXF83013.1 - 0.0003 20.4 0.2 0.011 15.2 0.0 2.2 2 0 0 2 2 2 1 Nicastrin Peptidase_M42 PF05343.14 EXF83013.1 - 0.06 12.4 0.0 0.2 10.6 0.0 1.9 1 1 1 2 2 2 0 M42 glutamyl aminopeptidase ThrE PF06738.12 EXF83015.1 - 9.7e-67 224.8 4.5 9.7e-67 224.8 4.5 2.5 3 0 0 3 3 3 2 Putative threonine/serine exporter ThrE_2 PF12821.7 EXF83015.1 - 4.8e-06 26.7 24.9 5.3e-05 23.4 0.6 4.1 4 0 0 4 4 4 3 Threonine/Serine exporter, ThrE NPR2 PF06218.11 EXF83015.1 - 0.2 10.4 0.0 0.31 9.7 0.0 1.2 1 0 0 1 1 1 0 Nitrogen permease regulator 2 Hepcidin PF06446.12 EXF83016.1 - 0.027 14.9 1.9 0.028 14.8 0.7 1.7 2 0 0 2 2 2 0 Hepcidin DUF2946 PF11162.8 EXF83016.1 - 0.14 12.8 2.2 0.12 13.0 0.5 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2946) MFS_1 PF07690.16 EXF83019.1 - 1.1e-31 110.1 44.7 2.8e-30 105.4 23.7 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF83019.1 - 1.3e-30 106.6 22.3 1.5e-28 99.9 22.3 2.5 1 1 0 1 1 1 1 Sugar (and other) transporter DUF4046 PF13255.6 EXF83019.1 - 0.18 12.4 0.0 0.8 10.3 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4046) DUF1729 PF08354.10 EXF83021.1 - 0.017 14.0 0.1 0.024 13.5 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1729) Ank_2 PF12796.7 EXF83022.1 - 1.9e-38 130.9 0.0 8.1e-15 55.2 0.0 6.0 4 2 2 7 7 7 5 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EXF83022.1 - 7.2e-30 102.7 0.1 1.5e-06 28.4 0.1 6.8 4 2 3 7 7 7 5 Ankyrin repeats (many copies) Ank_4 PF13637.6 EXF83022.1 - 1.5e-22 79.7 0.0 3.1e-05 24.4 0.1 7.2 3 2 6 9 9 9 6 Ankyrin repeats (many copies) Ank PF00023.30 EXF83022.1 - 6.9e-21 73.7 0.3 0.0028 18.0 0.0 9.1 9 1 0 9 9 9 4 Ankyrin repeat Ank_3 PF13606.6 EXF83022.1 - 9.5e-19 65.5 0.4 0.028 15.0 0.0 8.9 9 0 0 9 9 8 3 Ankyrin repeat NACHT PF05729.12 EXF83022.1 - 0.0005 20.0 2.3 0.0034 17.3 0.1 3.3 4 1 0 4 4 4 1 NACHT domain AAA_22 PF13401.6 EXF83022.1 - 0.00064 20.0 0.0 0.0019 18.5 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EXF83022.1 - 0.033 13.9 0.0 0.057 13.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain Parvo_NS1 PF01057.17 EXF83022.1 - 0.11 11.5 0.1 0.2 10.7 0.1 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_16 PF13191.6 EXF83022.1 - 0.15 12.4 0.0 0.49 10.8 0.0 1.9 1 1 0 1 1 1 0 AAA ATPase domain DUF2075 PF09848.9 EXF83022.1 - 0.22 10.7 0.0 0.33 10.1 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_19 PF13245.6 EXF83022.1 - 0.33 11.3 1.0 0.83 10.0 0.1 2.0 2 0 0 2 2 2 0 AAA domain Peptidase_S8 PF00082.22 EXF83024.1 - 9.2e-19 67.8 0.0 2.5e-18 66.4 0.0 1.7 1 1 0 1 1 1 1 Subtilase family BPL_LplA_LipB PF03099.19 EXF83025.1 - 0.12 12.3 0.0 0.13 12.2 0.0 1.1 1 0 0 1 1 1 0 Biotin/lipoate A/B protein ligase family Y_phosphatase3 PF13350.6 EXF83026.1 - 1.2e-47 162.8 0.0 1.4e-47 162.6 0.0 1.1 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 EXF83026.1 - 0.0086 15.7 0.0 0.012 15.2 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase2 PF03162.13 EXF83026.1 - 0.022 14.4 0.0 0.034 13.7 0.0 1.2 1 0 0 1 1 1 0 Tyrosine phosphatase family PTPlike_phytase PF14566.6 EXF83026.1 - 0.12 12.4 0.0 0.56 10.3 0.0 2.0 2 0 0 2 2 2 0 Inositol hexakisphosphate Amidohydro_3 PF07969.11 EXF83027.1 - 2.3e-68 231.8 0.1 2.9e-68 231.5 0.1 1.0 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_1 PF01979.20 EXF83027.1 - 4.8e-06 26.1 0.0 0.00023 20.6 0.0 2.3 2 1 0 2 2 2 2 Amidohydrolase family MFS_1 PF07690.16 EXF83028.1 - 8.7e-15 54.5 25.9 8.7e-15 54.5 25.9 2.5 1 1 2 3 3 3 1 Major Facilitator Superfamily PUCC PF03209.15 EXF83028.1 - 0.0018 17.4 3.1 0.0018 17.4 3.1 3.1 3 2 1 4 4 4 1 PUCC protein Sugar_tr PF00083.24 EXF83028.1 - 8.3 5.1 24.2 0.078 11.8 7.8 3.4 2 1 1 3 3 3 0 Sugar (and other) transporter Methyltransf_23 PF13489.6 EXF83029.1 - 2.7e-21 76.1 0.0 4e-21 75.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF83029.1 - 6.3e-11 42.8 0.0 2e-10 41.2 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF83029.1 - 4.5e-09 36.8 0.0 8.5e-09 35.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF83029.1 - 5e-07 30.4 0.0 3.9e-06 27.5 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF83029.1 - 1.2e-06 28.4 0.0 2.2e-05 24.3 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EXF83029.1 - 0.024 14.2 0.0 0.05 13.2 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase small domain Ubie_methyltran PF01209.18 EXF83029.1 - 0.042 13.2 0.0 0.38 10.1 0.0 2.2 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family DREV PF05219.12 EXF83029.1 - 0.13 11.4 0.0 0.19 10.8 0.0 1.2 1 0 0 1 1 1 0 DREV methyltransferase PrmA PF06325.13 EXF83029.1 - 0.14 11.5 0.0 0.25 10.7 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Opy2 PF09463.10 EXF83030.1 - 2e-08 34.4 18.1 3.1e-08 33.8 18.1 1.3 1 0 0 1 1 1 1 Opy2 protein Mid2 PF04478.12 EXF83030.1 - 0.057 13.3 0.1 0.11 12.4 0.1 1.4 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor Chitin_synth_1 PF01644.17 EXF83031.1 - 4e-68 228.5 0.0 5.6e-68 228.0 0.0 1.2 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.11 EXF83031.1 - 1e-27 95.8 0.0 2.3e-27 94.7 0.0 1.6 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.15 EXF83031.1 - 1.4e-26 93.2 0.1 1.4e-21 76.7 0.0 2.3 2 0 0 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.6 EXF83031.1 - 4.9e-08 33.1 2.3 4.9e-08 33.1 2.3 2.3 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 EXF83031.1 - 0.017 15.1 0.0 0.042 13.7 0.0 1.7 2 0 0 2 2 2 0 Glycosyltransferase like family 2 UQ_con PF00179.26 EXF83032.1 - 8.1e-37 126.0 0.0 1.2e-36 125.4 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme IlvN PF07991.12 EXF83033.1 - 4.5e-46 156.4 0.0 8.5e-46 155.5 0.0 1.4 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain IlvC PF01450.19 EXF83033.1 - 2.4e-41 141.4 0.0 3.6e-41 140.8 0.0 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain F420_oxidored PF03807.17 EXF83033.1 - 0.015 15.9 0.1 0.061 13.9 0.0 2.1 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent Fungal_TACC PF12709.7 EXF83034.1 - 2.5e-10 40.7 2.4 2.5e-10 40.7 2.4 3.9 3 1 1 4 4 4 2 Fungal Transforming acidic coiled-coil (TACC) proteins DUF1848 PF08902.11 EXF83034.1 - 0.023 14.4 0.9 0.023 14.4 0.9 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1848) DUF4482 PF14818.6 EXF83034.1 - 1.3 9.9 23.4 0.081 13.8 2.6 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4482) LPP PF04728.13 EXF83034.1 - 1.8 9.0 4.9 6.3 7.3 0.2 3.5 3 0 0 3 3 3 0 Lipoprotein leucine-zipper GIT_CC PF16559.5 EXF83034.1 - 2.2 8.2 5.0 5.1 7.0 0.0 3.2 4 0 0 4 4 4 0 GIT coiled-coil Rho guanine nucleotide exchange factor FliE PF02049.18 EXF83034.1 - 4.2 7.6 8.7 3.6 7.8 2.1 2.9 2 1 0 2 2 2 0 Flagellar hook-basal body complex protein FliE SNF2_N PF00176.23 EXF83035.1 - 1.2e-65 221.5 0.8 1.2e-65 221.5 0.8 2.0 2 0 0 2 2 2 1 SNF2 family N-terminal domain DBINO PF13892.6 EXF83035.1 - 4.5e-48 163.0 19.7 4.5e-48 163.0 19.7 7.2 8 0 0 8 8 8 1 DNA-binding domain Helicase_C PF00271.31 EXF83035.1 - 8.2e-20 71.2 0.0 1.8e-19 70.1 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EXF83035.1 - 5.6e-08 33.0 0.0 5.6e-08 33.0 0.0 2.7 4 0 0 4 4 4 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 EXF83035.1 - 0.024 13.8 0.0 0.024 13.8 0.0 4.1 4 0 0 4 4 4 0 Class II histone deacetylase complex subunits 2 and 3 Fe_hyd_lg_C PF02906.14 EXF83035.1 - 0.55 9.9 5.8 0.45 10.1 2.1 2.4 2 0 0 2 2 2 0 Iron only hydrogenase large subunit, C-terminal domain Glyco_hydro_28 PF00295.17 EXF83037.1 - 5.5e-106 354.3 22.3 6.3e-106 354.1 22.3 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 adh_short PF00106.25 EXF83038.1 - 6e-25 87.8 0.0 3.4e-20 72.3 0.0 2.2 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EXF83038.1 - 2.5e-11 43.6 0.0 2.8e-09 36.9 0.0 2.1 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF83038.1 - 1.1e-10 41.7 0.0 1.7e-10 41.1 0.0 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EXF83038.1 - 0.0002 20.9 0.0 0.00033 20.2 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EXF83038.1 - 0.0086 15.2 0.0 0.013 14.6 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Glyco_tran_WecB PF03808.13 EXF83038.1 - 0.031 14.2 0.1 4.8 7.1 0.0 2.4 2 1 0 2 2 2 0 Glycosyl transferase WecB/TagA/CpsF family Sacchrp_dh_NADP PF03435.18 EXF83038.1 - 0.038 14.2 0.1 0.13 12.6 0.0 1.8 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain DUF4141 PF13605.6 EXF83038.1 - 0.056 12.7 0.4 0.1 11.9 0.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4141) Amidohydro_2 PF04909.14 EXF83038.1 - 0.063 13.1 0.0 0.59 9.9 0.0 2.3 3 0 0 3 3 3 0 Amidohydrolase Shikimate_DH PF01488.20 EXF83038.1 - 0.064 13.3 0.0 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase NUMOD1 PF07453.13 EXF83038.1 - 0.13 12.6 0.4 0.32 11.3 0.1 1.8 2 0 0 2 2 2 0 NUMOD1 domain Glyco_hydro_43 PF04616.14 EXF83039.1 - 3.1e-67 226.9 0.1 4.1e-67 226.5 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 GH43_C2 PF17851.1 EXF83039.1 - 5.8e-09 36.0 0.0 9.6e-09 35.2 0.0 1.3 1 0 0 1 1 1 1 Beta xylosidase C-terminal Concanavalin A-like domain Acetyltransf_3 PF13302.7 EXF83040.1 - 2e-13 51.2 0.0 2.8e-13 50.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain B3 PF02362.21 EXF83043.1 - 0.084 12.7 0.0 0.15 11.9 0.0 1.5 1 1 0 1 1 1 0 B3 DNA binding domain Glyco_hydro_20 PF00728.22 EXF83044.1 - 1.4e-28 100.4 0.0 4.5e-28 98.7 0.0 1.8 1 1 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glyco_hydro_20b PF02838.15 EXF83044.1 - 3.1e-07 31.2 0.1 1.1e-06 29.5 0.0 1.9 2 0 0 2 2 2 1 Glycosyl hydrolase family 20, domain 2 DUF3841 PF12952.7 EXF83044.1 - 0.15 11.8 0.1 0.26 11.1 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3841) HATPase_c PF02518.26 EXF83045.1 - 5e-22 78.5 0.2 9.7e-22 77.6 0.2 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EXF83045.1 - 2.1e-18 66.5 0.0 4.5e-18 65.5 0.0 1.6 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 EXF83045.1 - 1.3e-10 41.1 0.2 3.1e-09 36.8 0.2 2.5 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain AA_permease_2 PF13520.6 EXF83046.1 - 2e-62 211.4 54.8 2.5e-62 211.1 54.8 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EXF83046.1 - 3.8e-27 95.0 50.9 5e-27 94.6 50.9 1.0 1 0 0 1 1 1 1 Amino acid permease NUDIX PF00293.28 EXF83047.1 - 2.9e-15 56.5 0.0 2e-14 53.8 0.0 1.9 2 0 0 2 2 2 1 NUDIX domain F-box-like PF12937.7 EXF83048.1 - 0.0005 19.9 0.3 0.0015 18.4 0.3 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EXF83048.1 - 0.0048 16.7 0.5 0.018 14.9 0.5 2.0 1 1 0 1 1 1 1 F-box domain Glyco_hydro_26 PF02156.15 EXF83049.1 - 7.3e-89 298.3 7.1 9.1e-89 298.0 7.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 26 CBM_35 PF16990.5 EXF83049.1 - 2.9e-29 101.8 2.4 5.4e-29 100.9 2.4 1.5 1 0 0 1 1 1 1 Carbohydrate binding module (family 35) p450 PF00067.22 EXF83050.1 - 5.9e-28 97.8 0.0 1.5e-27 96.5 0.0 1.5 1 1 0 1 1 1 1 Cytochrome P450 QIL1 PF15884.5 EXF83050.1 - 0.034 14.7 0.0 4.6 7.9 0.0 2.7 2 0 0 2 2 2 0 MICOS complex subunit MIC13, QIL1 Glyco_hydro_6 PF01341.17 EXF83051.1 - 2.7e-99 332.7 0.1 3.6e-99 332.3 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 6 Fimbrial_K88 PF02432.15 EXF83051.1 - 0.046 13.7 0.3 0.18 11.8 0.2 1.9 2 0 0 2 2 2 0 Fimbrial, major and minor subunit p450 PF00067.22 EXF83052.1 - 7e-28 97.6 0.6 2.3e-25 89.3 0.2 2.2 2 0 0 2 2 2 2 Cytochrome P450 OTT_1508_deam PF14441.6 EXF83053.1 - 1.4e-19 69.8 0.1 2.7e-19 68.9 0.1 1.5 1 0 0 1 1 1 1 OTT_1508-like deaminase MF_alpha_N PF05436.11 EXF83055.1 - 0.064 13.2 0.0 0.086 12.8 0.0 1.2 1 0 0 1 1 1 0 Mating factor alpha precursor N-terminus Fer4_6 PF12837.7 EXF83055.1 - 3.2 8.0 11.8 1.9 8.7 5.8 2.7 2 1 0 2 2 2 0 4Fe-4S binding domain DUF3262 PF11660.8 EXF83057.1 - 6.9 7.1 10.4 3 8.3 0.4 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF3262) FAD_binding_3 PF01494.19 EXF83058.1 - 5.1e-89 298.9 0.0 7.1e-89 298.5 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Phe_hydrox_dim PF07976.12 EXF83058.1 - 4.6e-57 192.7 0.0 7.7e-57 191.9 0.0 1.4 1 0 0 1 1 1 1 Phenol hydroxylase, C-terminal dimerisation domain FAD_binding_2 PF00890.24 EXF83058.1 - 3.5e-05 23.1 0.3 6.1e-05 22.3 0.3 1.4 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 EXF83058.1 - 5.7e-05 22.0 0.2 8.7e-05 21.4 0.2 1.2 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_2 PF07992.14 EXF83058.1 - 0.0011 18.3 0.2 0.0023 17.2 0.2 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EXF83058.1 - 0.004 16.5 0.1 0.0062 15.8 0.1 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EXF83058.1 - 0.0059 15.9 0.0 0.031 13.5 0.0 2.0 2 0 0 2 2 2 1 Thi4 family NAD_binding_8 PF13450.6 EXF83058.1 - 0.011 16.0 0.1 0.046 13.9 0.1 2.1 2 0 0 2 2 1 0 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 EXF83058.1 - 0.017 14.3 0.4 0.026 13.6 0.4 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A AlaDh_PNT_C PF01262.21 EXF83058.1 - 0.018 14.4 0.0 0.029 13.7 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain FAD_oxidored PF12831.7 EXF83058.1 - 0.024 14.0 0.2 0.039 13.3 0.2 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 EXF83058.1 - 0.037 13.1 0.1 0.075 12.1 0.1 1.5 1 0 0 1 1 1 0 Lycopene cyclase protein Trp_halogenase PF04820.14 EXF83058.1 - 0.1 11.4 0.0 0.22 10.3 0.0 1.6 1 0 0 1 1 1 0 Tryptophan halogenase OTT_1508_deam PF14441.6 EXF83060.1 - 4.3e-20 71.5 0.2 7.6e-20 70.7 0.2 1.4 1 0 0 1 1 1 1 OTT_1508-like deaminase Cupin_2 PF07883.11 EXF83062.1 - 9.3e-13 47.7 0.2 1.9e-09 37.1 0.1 2.4 2 0 0 2 2 2 2 Cupin domain Cupin_3 PF05899.12 EXF83062.1 - 0.00029 20.5 0.1 0.055 13.2 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF861) Ppnp PF06865.11 EXF83062.1 - 0.0069 16.8 0.0 0.041 14.3 0.0 2.2 2 0 0 2 2 2 1 Pyrimidine/purine nucleoside phosphorylase AraC_binding PF02311.19 EXF83062.1 - 0.0073 16.2 0.0 0.073 13.0 0.0 2.2 2 0 0 2 2 2 1 AraC-like ligand binding domain Cupin_4 PF08007.12 EXF83062.1 - 0.089 12.2 0.3 0.26 10.7 0.0 1.8 2 0 0 2 2 2 0 Cupin superfamily protein Abhydrolase_3 PF07859.13 EXF83063.1 - 3e-14 53.4 0.0 2.1e-08 34.3 0.1 2.5 3 0 0 3 3 3 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EXF83063.1 - 2.4e-11 43.5 0.1 8.5e-08 31.9 0.0 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family COesterase PF00135.28 EXF83063.1 - 1.9e-06 27.0 0.0 3e-06 26.4 0.0 1.2 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_2 PF02230.16 EXF83063.1 - 0.00014 21.7 0.0 0.08 12.7 0.0 2.3 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase Peptidase_S15 PF02129.18 EXF83063.1 - 0.00023 20.9 0.0 0.0015 18.2 0.0 2.1 1 1 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) DLH PF01738.18 EXF83063.1 - 0.00045 19.9 0.0 0.0014 18.3 0.0 1.8 3 0 0 3 3 3 1 Dienelactone hydrolase family Abhydrolase_1 PF00561.20 EXF83063.1 - 0.0056 16.3 0.2 1 9.0 0.0 2.8 1 1 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EXF83063.1 - 0.012 14.9 0.0 0.25 10.6 0.0 2.5 3 0 0 3 3 3 0 Serine aminopeptidase, S33 FSH1 PF03959.13 EXF83063.1 - 0.08 12.6 0.0 0.21 11.2 0.0 1.6 2 0 0 2 2 2 0 Serine hydrolase (FSH1) AXE1 PF05448.12 EXF83063.1 - 0.15 10.7 0.0 0.96 8.1 0.0 1.9 2 0 0 2 2 2 0 Acetyl xylan esterase (AXE1) Sugar_tr PF00083.24 EXF83064.1 - 1.3e-64 218.8 27.6 1.5e-64 218.6 27.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF83064.1 - 8.3e-19 67.7 34.1 8.3e-19 67.7 34.1 2.5 1 1 2 3 3 3 2 Major Facilitator Superfamily MFS_2 PF13347.6 EXF83064.1 - 0.0042 15.7 10.8 0.0042 15.7 10.8 3.1 2 2 1 3 3 3 2 MFS/sugar transport protein Peptidase_C7 PF01830.18 EXF83064.1 - 0.11 11.9 0.2 0.99 8.8 0.0 2.2 2 0 0 2 2 2 0 Peptidase C7 family Fungal_trans PF04082.18 EXF83065.1 - 3.3e-17 62.4 0.0 8.2e-17 61.1 0.0 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF83065.1 - 1.7e-06 28.0 10.4 1.7e-06 28.0 10.4 2.1 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Glyco_hydro_3_C PF01915.22 EXF83066.1 - 2.2e-55 187.8 0.0 4.4e-55 186.8 0.0 1.5 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 EXF83066.1 - 2.8e-47 161.7 0.0 8.1e-47 160.1 0.0 1.8 2 0 0 2 2 2 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 EXF83066.1 - 1.1e-21 76.7 0.7 2.3e-21 75.7 0.7 1.6 1 0 0 1 1 1 1 Fibronectin type III-like domain PA14 PF07691.12 EXF83066.1 - 8.2e-06 25.7 0.0 1.6e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 PA14 domain GLEYA PF10528.9 EXF83066.1 - 0.005 17.2 0.0 0.013 15.9 0.0 1.6 1 0 0 1 1 1 1 GLEYA domain WYL_2 PF10902.8 EXF83066.1 - 0.012 15.9 0.1 2.5 8.5 0.0 2.7 2 0 0 2 2 2 0 WYL_2, Sm-like SH3 beta-barrel fold hnRNP_Q_AcD PF18360.1 EXF83066.1 - 0.13 12.2 0.0 0.29 11.1 0.0 1.5 1 0 0 1 1 1 0 Heterogeneous nuclear ribonucleoprotein Q acidic domain Peptidase_S8 PF00082.22 EXF83068.1 - 2.7e-44 151.6 4.4 8.2e-43 146.8 5.3 2.2 2 0 0 2 2 2 1 Subtilase family fn3_5 PF06280.12 EXF83068.1 - 2.9e-11 44.1 0.1 6.1e-11 43.0 0.1 1.6 1 0 0 1 1 1 1 Fn3-like domain DUF916 PF06030.12 EXF83068.1 - 0.016 15.3 0.0 0.034 14.2 0.0 1.5 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF916) FixG_C PF11614.8 EXF83068.1 - 0.14 12.3 0.0 0.78 10.0 0.0 2.0 1 1 0 1 1 1 0 IG-like fold at C-terminal of FixG, putative oxidoreductase WHH PF14414.6 EXF83069.1 - 0.031 14.2 0.0 0.056 13.3 0.0 1.4 1 0 0 1 1 1 0 A nuclease of the HNH/ENDO VII superfamily with conserved WHH Lactamase_B PF00753.27 EXF83070.1 - 4.7e-14 52.9 0.3 2.8e-13 50.3 0.2 1.9 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EXF83070.1 - 0.00012 21.7 0.2 0.00033 20.2 0.2 1.8 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 EXF83070.1 - 0.0031 17.4 0.0 0.0069 16.3 0.0 1.6 1 0 0 1 1 1 1 Beta-lactamase superfamily domain FAD_binding_4 PF01565.23 EXF83071.1 - 7.3e-18 64.6 0.7 1.2e-17 63.9 0.7 1.4 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 EXF83072.1 - 0.00023 21.3 0.1 0.0028 17.9 0.0 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EXF83072.1 - 0.0083 15.4 0.0 1.8 7.7 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Shikimate_DH PF01488.20 EXF83072.1 - 0.014 15.4 0.0 1.2 9.2 0.0 2.4 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase NAD_binding_9 PF13454.6 EXF83072.1 - 0.015 15.3 0.0 0.5 10.3 0.0 2.3 2 0 0 2 2 2 0 FAD-NAD(P)-binding DAO PF01266.24 EXF83072.1 - 0.14 11.8 0.1 2.3 7.7 0.0 2.3 2 1 0 2 2 2 0 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 EXF83072.1 - 0.21 10.8 0.0 5.2 6.2 0.0 2.2 2 0 0 2 2 2 0 FAD binding domain Fungal_trans PF04082.18 EXF83073.1 - 5.3e-12 45.3 0.0 1.1e-11 44.3 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Questin_oxidase PF14027.6 EXF83074.1 - 1.8e-81 274.4 3.1 2.2e-81 274.1 3.1 1.1 1 0 0 1 1 1 1 Questin oxidase-like DAO_C PF16901.5 EXF83074.1 - 0.05 13.5 0.0 0.12 12.3 0.0 1.7 1 0 0 1 1 1 0 C-terminal domain of alpha-glycerophosphate oxidase Pyr_redox_3 PF13738.6 EXF83076.1 - 2.4e-15 56.6 2.0 5.4e-14 52.2 0.8 2.7 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EXF83076.1 - 3.5e-13 49.4 0.1 3.8e-09 36.2 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EXF83076.1 - 4.6e-11 42.5 0.4 4.2e-09 36.0 0.2 2.9 2 1 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox PF00070.27 EXF83076.1 - 4.8e-05 23.8 0.0 0.0085 16.6 0.0 3.1 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 EXF83076.1 - 7.1e-05 21.4 0.5 0.0012 17.3 0.2 2.5 2 1 0 2 2 2 1 Flavin-binding monooxygenase-like Lycopene_cycl PF05834.12 EXF83076.1 - 0.0026 16.9 0.6 0.01 15.0 0.1 2.1 2 1 0 2 2 2 1 Lycopene cyclase protein FAD_binding_3 PF01494.19 EXF83076.1 - 0.0034 16.7 0.0 0.012 14.9 0.0 1.8 2 0 0 2 2 2 1 FAD binding domain NAD_binding_8 PF13450.6 EXF83076.1 - 0.0052 17.0 0.0 0.015 15.5 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 EXF83076.1 - 0.0077 15.6 0.0 0.013 14.9 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EXF83076.1 - 0.021 14.8 0.4 6.4 6.7 0.0 2.5 2 1 0 2 2 2 0 FAD-NAD(P)-binding rve_2 PF13333.6 EXF83076.1 - 0.035 14.3 0.3 0.072 13.3 0.3 1.5 1 0 0 1 1 1 0 Integrase core domain 2-Hacid_dh_C PF02826.19 EXF83076.1 - 0.036 13.4 0.0 0.072 12.4 0.0 1.5 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DAO PF01266.24 EXF83076.1 - 0.055 13.0 1.4 1.5 8.4 0.1 2.7 2 1 1 3 3 3 0 FAD dependent oxidoreductase Thi4 PF01946.17 EXF83076.1 - 0.12 11.6 0.0 0.27 10.4 0.0 1.5 1 0 0 1 1 1 0 Thi4 family FYRC PF05965.14 EXF83077.1 - 0.086 13.0 0.0 0.18 12.0 0.0 1.5 1 0 0 1 1 1 0 F/Y rich C-terminus DAG1 PF05454.11 EXF83078.1 - 0.0017 17.8 0.0 0.0023 17.4 0.0 1.3 1 0 0 1 1 1 1 Dystroglycan (Dystrophin-associated glycoprotein 1) Herpes_gE PF02480.16 EXF83078.1 - 0.01 14.6 0.0 0.012 14.4 0.0 1.1 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E Shisa PF13908.6 EXF83078.1 - 0.012 15.9 0.2 0.015 15.6 0.2 1.3 1 1 0 1 1 1 0 Wnt and FGF inhibitory regulator Insulin_TMD PF17870.1 EXF83078.1 - 0.018 15.1 0.4 0.032 14.3 0.4 1.4 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment RCR PF12273.8 EXF83078.1 - 0.018 15.7 0.0 0.03 15.0 0.0 1.4 1 0 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red DUF4690 PF15756.5 EXF83078.1 - 0.023 15.3 0.6 0.044 14.4 0.1 1.7 2 0 0 2 2 2 0 Small Novel Rich in Cartilage PsaL PF02605.15 EXF83078.1 - 0.031 13.9 0.0 0.038 13.6 0.0 1.2 1 0 0 1 1 1 0 Photosystem I reaction centre subunit XI EphA2_TM PF14575.6 EXF83078.1 - 0.042 14.7 0.0 0.05 14.5 0.0 1.3 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain TMEM154 PF15102.6 EXF83078.1 - 0.068 13.1 0.5 0.13 12.1 0.1 1.7 1 1 0 1 1 1 0 TMEM154 protein family FAD_binding_4 PF01565.23 EXF83079.1 - 2.3e-20 72.7 0.5 3.4e-20 72.2 0.5 1.3 1 0 0 1 1 1 1 FAD binding domain Sugar_tr PF00083.24 EXF83080.1 - 2.9e-87 293.4 26.7 3.6e-87 293.1 26.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF83080.1 - 2.6e-28 99.0 28.6 2.6e-28 99.0 28.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF1980 PF09323.10 EXF83080.1 - 0.16 11.9 3.4 0.78 9.6 3.4 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF1980) DUF1129 PF06570.11 EXF83080.1 - 0.44 10.0 4.0 0.94 8.9 4.0 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1129) MR_MLE_C PF13378.6 EXF83081.1 - 1.5e-48 165.3 0.2 2.1e-48 164.8 0.2 1.1 1 0 0 1 1 1 1 Enolase C-terminal domain-like MR_MLE_N PF02746.16 EXF83081.1 - 0.031 14.5 0.1 0.07 13.4 0.1 1.8 1 1 0 1 1 1 0 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain DUF3218 PF11508.8 EXF83081.1 - 0.078 12.5 0.0 0.16 11.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3218) Fungal_trans PF04082.18 EXF83082.1 - 8.3e-18 64.4 2.8 3e-17 62.6 2.8 1.9 1 1 0 1 1 1 1 Fungal specific transcription factor domain Sugar_tr PF00083.24 EXF83083.1 - 2.1e-98 330.1 17.6 2.4e-98 330.0 17.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF83083.1 - 5.8e-39 134.0 33.3 2.4e-32 112.2 14.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EXF83083.1 - 2.2e-07 29.7 10.4 3.2e-05 22.6 2.2 2.1 2 0 0 2 2 2 2 Fungal trichothecene efflux pump (TRI12) Transgly_assoc PF04226.13 EXF83083.1 - 4.2 7.7 12.0 3.4 8.0 0.2 3.4 3 0 0 3 3 3 0 Transglycosylase associated protein 2-Hacid_dh_C PF02826.19 EXF83084.1 - 4.5e-48 162.9 0.1 6.7e-48 162.4 0.1 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EXF83084.1 - 1.2e-07 31.4 0.0 1.6e-07 31.1 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 EXF83084.1 - 0.00021 21.5 0.1 0.0003 21.0 0.1 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase HTH_1 PF00126.27 EXF83084.1 - 0.1 12.6 0.0 0.23 11.4 0.0 1.5 1 0 0 1 1 1 0 Bacterial regulatory helix-turn-helix protein, lysR family MFS_1 PF07690.16 EXF83085.1 - 2.6e-24 85.8 20.0 2.6e-24 85.8 20.0 1.3 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF2776 PF10951.8 EXF83085.1 - 0.0079 15.5 2.4 0.26 10.5 0.0 2.8 3 1 1 4 4 4 2 Protein of unknown function (DUF2776) Trp_oprn_chp PF09534.10 EXF83085.1 - 0.058 13.2 0.2 2.6 7.8 0.0 2.2 2 0 0 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Peptidase_M20 PF01546.28 EXF83086.1 - 9.8e-07 28.7 0.1 1.5e-06 28.0 0.1 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EXF83086.1 - 2.5e-06 27.4 0.1 7.7e-06 25.8 0.1 1.8 1 0 0 1 1 1 1 Peptidase dimerisation domain LEA_6 PF10714.9 EXF83086.1 - 0.092 12.8 0.4 0.37 10.9 0.0 2.1 2 0 0 2 2 2 0 Late embryogenesis abundant protein 18 BCS1_N PF08740.11 EXF83089.1 - 1e-49 169.1 0.4 1e-49 169.1 0.4 1.7 2 0 0 2 2 2 1 BCS1 N terminal AAA PF00004.29 EXF83089.1 - 2.5e-16 60.3 0.0 1.8e-07 31.6 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EXF83089.1 - 0.004 16.9 0.0 0.0067 16.2 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_25 PF13481.6 EXF83089.1 - 0.021 14.4 0.0 0.051 13.2 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_5 PF07728.14 EXF83089.1 - 0.043 13.8 0.0 0.13 12.3 0.0 1.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) ATPase PF06745.13 EXF83089.1 - 0.063 12.6 0.0 0.12 11.7 0.0 1.4 1 0 0 1 1 1 0 KaiC AAA_16 PF13191.6 EXF83089.1 - 0.14 12.5 0.2 0.39 11.1 0.2 1.9 1 1 0 1 1 1 0 AAA ATPase domain Tau95 PF09734.9 EXF83090.1 - 1.4e-35 123.1 0.2 3.1e-35 122.0 0.2 1.6 1 0 0 1 1 1 1 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain Tau95_N PF17682.1 EXF83090.1 - 1.4e-34 119.0 0.0 2.4e-34 118.3 0.0 1.4 1 0 0 1 1 1 1 Tau95 Triple barrel domain B56 PF01603.20 EXF83091.1 - 9.8e-193 640.8 4.5 1.2e-192 640.5 4.5 1.0 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) Sec7_N PF12783.7 EXF83091.1 - 0.0007 19.5 1.7 0.31 10.9 0.0 2.4 2 0 0 2 2 2 2 Guanine nucleotide exchange factor in Golgi transport N-terminal CTD_bind PF04818.13 EXF83092.1 - 7.6e-14 52.3 0.2 7.7e-13 49.1 0.1 2.4 3 0 0 3 3 3 1 RNA polymerase II-binding domain. DUF4748 PF15932.5 EXF83093.1 - 3.7e-26 90.6 0.8 5.4e-26 90.1 0.8 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4748) EphA2_TM PF14575.6 EXF83094.1 - 0.13 13.1 0.0 0.38 11.7 0.0 1.7 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Exo_endo_phos PF03372.23 EXF83095.1 - 3.3e-10 39.9 0.0 8.4e-10 38.6 0.0 1.7 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Orn_Arg_deC_N PF02784.16 EXF83096.1 - 7.6e-84 280.9 0.0 1e-83 280.5 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.22 EXF83096.1 - 3.7e-19 68.8 0.0 1.4e-18 67.0 0.0 1.8 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain M16C_assoc PF08367.11 EXF83097.1 - 4.4e-86 288.1 0.0 6.4e-86 287.6 0.0 1.2 1 0 0 1 1 1 1 Peptidase M16C associated Peptidase_M16_C PF05193.21 EXF83097.1 - 3.8e-33 115.0 0.0 4e-22 79.1 0.0 3.2 3 0 0 3 3 3 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EXF83097.1 - 5.7e-09 36.1 0.1 1.9e-07 31.1 0.0 3.0 3 0 0 3 3 3 1 Insulinase (Peptidase family M16) UvrA_inter PF17760.1 EXF83097.1 - 0.0058 16.7 0.1 0.044 13.9 0.1 2.3 2 0 0 2 2 2 1 UvrA interaction domain Taxilin PF09728.9 EXF83098.1 - 6.2e-89 298.2 59.6 6.2e-89 298.2 59.6 1.9 1 1 1 2 2 2 1 Myosin-like coiled-coil protein DUF4810 PF16068.5 EXF83098.1 - 0.0017 18.9 0.1 0.0017 18.9 0.1 4.6 5 1 0 5 5 5 1 Domain of unknown function (DUF4810) Cep57_CLD_2 PF14197.6 EXF83098.1 - 0.003 17.6 1.2 0.003 17.6 1.2 5.7 3 2 3 6 6 6 1 Centrosome localisation domain of PPC89 Syntaxin PF00804.25 EXF83098.1 - 0.0072 16.0 4.6 0.0072 16.0 4.6 4.4 2 1 3 5 5 5 1 Syntaxin HNF-1B_C PF04812.13 EXF83099.1 - 0.094 12.5 3.0 0.091 12.6 0.6 1.9 2 0 0 2 2 2 0 Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus zf-C2H2 PF00096.26 EXF83101.1 - 3.5e-17 61.8 17.9 0.0017 18.7 0.2 5.6 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EXF83101.1 - 3e-16 58.7 16.4 0.0033 18.2 0.1 5.5 5 0 0 5 5 5 5 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EXF83101.1 - 5.3e-15 55.0 15.5 1.1e-05 25.3 0.1 4.8 5 0 0 5 5 5 3 C2H2-type zinc finger zf-C2H2_8 PF15909.5 EXF83101.1 - 4.7e-09 36.4 13.0 1.4e-05 25.3 2.6 3.3 2 1 0 3 3 3 2 C2H2-type zinc ribbon zf-met PF12874.7 EXF83101.1 - 1.1e-08 35.1 11.4 0.064 13.7 0.3 5.8 5 1 1 6 6 6 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EXF83101.1 - 6.4e-07 29.5 5.7 0.25 11.7 0.0 5.3 5 0 0 5 5 5 2 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 EXF83101.1 - 7e-05 23.1 13.1 1.8 8.9 0.6 5.2 2 2 3 5 5 5 1 C2H2 type zinc-finger (2 copies) zf-Di19 PF05605.12 EXF83101.1 - 9.6e-05 22.6 12.2 0.074 13.4 3.1 3.8 3 0 0 3 3 3 2 Drought induced 19 protein (Di19), zinc-binding zf-H2C2_2 PF13465.6 EXF83101.1 - 0.00012 22.3 17.9 0.0013 19.0 0.2 5.2 5 0 0 5 5 5 1 Zinc-finger double domain FOXP-CC PF16159.5 EXF83101.1 - 0.00064 20.3 8.0 2.3 8.9 0.1 4.8 2 2 2 4 4 4 1 FOXP coiled-coil domain zf-C2H2_9 PF16293.5 EXF83101.1 - 0.0019 18.0 8.5 3.5 7.6 0.1 5.2 2 2 3 5 5 5 1 C2H2 type zinc-finger (1 copy) zf-RING_5 PF14634.6 EXF83101.1 - 0.0096 15.9 4.8 0.0096 15.9 4.8 2.9 3 0 0 3 3 3 1 zinc-RING finger domain zf-C2H2_3rep PF18868.1 EXF83101.1 - 0.025 15.3 6.5 0.49 11.1 2.0 3.6 3 1 0 3 3 3 0 Zinc finger C2H2-type, 3 repeats Yippee-Mis18 PF03226.14 EXF83101.1 - 0.058 13.6 1.9 2.6 8.3 0.7 2.4 2 0 0 2 2 2 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly zf_C2H2_ZHX PF18387.1 EXF83101.1 - 0.067 12.8 5.0 0.83 9.3 2.3 2.7 2 0 0 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-C2HC_2 PF13913.6 EXF83101.1 - 0.067 13.1 13.5 10 6.1 0.4 5.2 5 0 0 5 5 5 0 zinc-finger of a C2HC-type Trm112p PF03966.16 EXF83101.1 - 0.083 13.5 2.4 0.62 10.7 0.4 2.9 2 1 0 2 2 2 0 Trm112p-like protein zf-C2H2_12 PF18658.1 EXF83101.1 - 0.1 12.2 1.6 0.91 9.1 0.8 2.5 2 0 0 2 2 2 0 Zinc-finger C2H2-type zf-MYST PF17772.1 EXF83101.1 - 0.15 11.7 1.0 0.44 10.2 0.1 2.2 2 0 0 2 2 2 0 MYST family zinc finger domain zf-C2H2_11 PF16622.5 EXF83101.1 - 0.23 11.3 0.1 0.23 11.3 0.1 3.5 4 0 0 4 4 4 0 zinc-finger C2H2-type zinc_ribbon_9 PF14369.6 EXF83101.1 - 0.3 11.4 2.7 0.99 9.7 0.0 3.1 3 0 0 3 3 3 0 zinc-ribbon DUF678 PF05077.12 EXF83101.1 - 0.34 11.0 5.5 1.2 9.3 0.1 3.2 2 2 2 4 4 3 0 Protein of unknown function (DUF678) DUF2256 PF10013.9 EXF83101.1 - 0.35 11.0 7.1 29 4.9 0.0 4.4 4 0 0 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2256) zf_ZIC PF18366.1 EXF83101.1 - 0.47 10.6 5.5 6.5 6.9 0.0 3.7 3 1 1 4 4 4 0 Zic proteins zinc finger domain zf-C2H2_aberr PF17017.5 EXF83101.1 - 0.67 10.1 3.5 4.9 7.3 0.1 2.9 2 1 0 2 2 2 0 Aberrant zinc-finger Zn-ribbon_8 PF09723.10 EXF83101.1 - 0.99 9.6 9.1 1.5 9.0 0.7 3.4 3 0 0 3 3 3 0 Zinc ribbon domain zinc-ribbons_6 PF07191.12 EXF83101.1 - 1.9 8.5 11.0 48 4.0 0.3 4.0 2 1 2 4 4 4 0 zinc-ribbons zinc_ribbon_15 PF17032.5 EXF83101.1 - 7.7 7.3 10.6 12 6.7 2.9 3.3 2 1 0 2 2 2 0 zinc-ribbon family Pol_alpha_B_N PF08418.10 EXF83102.1 - 2.7e-88 296.1 0.2 3.4e-88 295.7 0.2 1.1 1 0 0 1 1 1 1 DNA polymerase alpha subunit B N-terminal DNA_pol_E_B PF04042.16 EXF83102.1 - 4.2e-42 143.9 0.1 5.9e-42 143.4 0.1 1.2 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B MFAP1 PF06991.11 EXF83103.1 - 2.9e-68 230.0 25.7 2.9e-68 230.0 25.7 3.3 3 1 0 3 3 3 1 Microfibril-associated/Pre-mRNA processing Alb1 PF09135.11 EXF83104.1 - 6e-28 97.8 18.4 1.1e-27 96.9 18.4 1.5 1 0 0 1 1 1 1 Alb1 CDC27 PF09507.10 EXF83104.1 - 1.6 8.1 21.9 1.9 7.8 21.9 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Red1 PF07964.11 EXF83104.1 - 7.2 4.7 12.9 8 4.6 12.9 1.0 1 0 0 1 1 1 0 Rec10 / Red1 MCM3AP_GANP PF16769.5 EXF83104.1 - 9.6 4.3 8.9 11 4.1 8.9 1.0 1 0 0 1 1 1 0 MCM3AP domain of GANP UCH PF00443.29 EXF83105.1 - 2.8e-36 125.4 0.0 4.5e-36 124.6 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EXF83105.1 - 5.5e-07 29.5 0.0 5.4e-06 26.2 0.0 2.4 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Cytochrom_B_N_2 PF13631.6 EXF83105.1 - 0.11 12.5 0.1 0.21 11.6 0.1 1.4 1 0 0 1 1 1 0 Cytochrome b(N-terminal)/b6/petB TENA_THI-4 PF03070.16 EXF83106.1 - 0.039 13.8 0.1 2 8.2 0.0 2.3 2 0 0 2 2 2 0 TENA/THI-4/PQQC family TPT PF03151.16 EXF83107.1 - 1.6e-29 103.2 23.1 2.1e-29 102.8 23.1 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family UAA PF08449.11 EXF83107.1 - 0.00035 19.9 23.5 0.00055 19.2 23.5 1.3 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 EXF83107.1 - 0.0072 16.5 42.2 0.026 14.7 15.2 2.7 3 0 0 3 3 3 2 EamA-like transporter family Glyco_transf_17 PF04724.13 EXF83109.1 - 1.2e-50 172.6 1.6 8.8e-50 169.7 1.6 1.9 1 1 0 1 1 1 1 Glycosyltransferase family 17 COMPASS-Shg1 PF05205.12 EXF83110.1 - 8.2e-26 90.7 0.1 8.2e-26 90.7 0.1 2.7 3 0 0 3 3 3 1 COMPASS (Complex proteins associated with Set1p) component shg1 PGA2 PF07543.12 EXF83111.1 - 6.7e-39 133.0 0.3 7.8e-39 132.8 0.3 1.0 1 0 0 1 1 1 1 Protein trafficking PGA2 CENP-S PF15630.6 EXF83112.1 - 1.8e-34 117.9 0.0 2.6e-34 117.5 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein CENP-T_C PF15511.6 EXF83112.1 - 4e-07 30.1 0.0 4.5e-07 30.0 0.0 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold Bromo_TP PF07524.13 EXF83112.1 - 0.00045 20.2 0.1 0.0044 17.0 0.0 2.0 1 1 1 2 2 2 1 Bromodomain associated TFIID-18kDa PF02269.16 EXF83112.1 - 0.0037 17.3 0.0 0.0052 16.8 0.0 1.2 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit Histone PF00125.24 EXF83112.1 - 0.0083 16.5 0.1 0.012 16.0 0.1 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 FliL PF03748.14 EXF83112.1 - 0.03 14.9 0.2 4.7 7.8 0.0 2.1 1 1 1 2 2 2 0 Flagellar basal body-associated protein FliL DUF956 PF06115.11 EXF83112.1 - 0.077 12.7 0.0 0.12 12.1 0.0 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF956) SF1-HH PF16275.5 EXF83113.1 - 0.11 12.9 0.1 0.31 11.4 0.1 1.7 1 0 0 1 1 1 0 Splicing factor 1 helix-hairpin domain Utp13 PF08625.11 EXF83114.1 - 4.5e-51 172.5 0.3 7.2e-51 171.8 0.3 1.3 1 0 0 1 1 1 1 Utp13 specific WD40 associated domain WD40 PF00400.32 EXF83114.1 - 2.9e-49 164.0 17.6 6.3e-05 23.7 0.0 11.8 11 1 0 11 11 11 9 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EXF83114.1 - 4e-12 46.3 3.0 0.92 9.9 0.0 8.1 6 2 3 9 9 9 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EXF83114.1 - 5.6e-06 25.3 5.2 0.15 10.7 0.0 5.2 4 2 2 6 6 6 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 EXF83114.1 - 0.0013 17.6 2.6 6.2 5.4 0.0 5.0 4 2 1 5 5 5 2 Nup133 N terminal like NQRA PF05896.11 EXF83114.1 - 0.12 11.8 0.0 1.4 8.3 0.0 2.1 2 0 0 2 2 2 0 Na(+)-translocating NADH-quinone reductase subunit A (NQRA) TPR_12 PF13424.6 EXF83115.1 - 1.7e-29 101.9 14.9 3.6e-12 46.4 0.2 5.1 3 1 1 4 4 4 4 Tetratricopeptide repeat TPR_10 PF13374.6 EXF83115.1 - 4.4e-26 90.0 21.5 0.00034 20.4 1.0 6.9 6 0 0 6 6 6 6 Tetratricopeptide repeat PNP_UDP_1 PF01048.20 EXF83115.1 - 1.3e-14 54.0 0.3 4.4e-14 52.3 0.3 2.0 1 1 0 1 1 1 1 Phosphorylase superfamily TPR_8 PF13181.6 EXF83115.1 - 4.8e-11 42.0 8.9 0.021 15.0 0.1 5.9 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.6 EXF83115.1 - 3.8e-10 39.1 16.6 0.024 14.6 0.3 6.0 6 0 0 6 6 5 4 Tetratricopeptide repeat TPR_2 PF07719.17 EXF83115.1 - 5e-09 35.6 10.3 0.01 15.9 0.1 5.9 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_1 PF00515.28 EXF83115.1 - 7.2e-07 28.8 6.9 0.81 9.6 0.1 5.3 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_MalT PF17874.1 EXF83115.1 - 1.7e-05 24.4 12.9 0.00075 19.0 10.5 2.3 1 1 1 2 2 2 2 MalT-like TPR region NB-ARC PF00931.22 EXF83115.1 - 5.2e-05 22.5 0.0 0.00023 20.5 0.0 2.0 1 1 0 1 1 1 1 NB-ARC domain AAA_22 PF13401.6 EXF83115.1 - 0.0002 21.6 0.0 0.00084 19.6 0.0 2.1 1 1 0 1 1 1 1 AAA domain TPR_16 PF13432.6 EXF83115.1 - 0.00026 21.5 9.9 0.12 13.1 0.0 5.0 5 2 0 5 5 3 2 Tetratricopeptide repeat PPR PF01535.20 EXF83115.1 - 0.0003 20.8 0.0 2.2 8.7 0.0 3.8 3 0 0 3 3 3 1 PPR repeat TPR_4 PF07721.14 EXF83115.1 - 0.00037 20.8 6.7 5 8.0 0.0 5.6 5 0 0 5 5 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 EXF83115.1 - 0.0024 18.3 16.4 0.29 11.7 0.4 5.8 4 1 2 7 7 5 1 Tetratricopeptide repeat TPR_20 PF14561.6 EXF83115.1 - 0.0064 16.8 9.8 0.48 10.8 0.0 4.7 4 1 2 6 6 5 2 Tetratricopeptide repeat TPR_14 PF13428.6 EXF83115.1 - 0.021 15.6 16.3 4.4 8.4 0.2 6.6 7 0 0 7 7 6 0 Tetratricopeptide repeat AAA_16 PF13191.6 EXF83115.1 - 0.12 12.8 0.1 0.72 10.2 0.1 2.4 1 1 0 1 1 1 0 AAA ATPase domain TPR_11 PF13414.6 EXF83115.1 - 0.19 11.4 1.0 12 5.7 0.1 3.4 3 0 0 3 3 3 0 TPR repeat TPR_21 PF09976.9 EXF83115.1 - 0.51 10.0 5.3 0.096 12.4 0.6 2.2 3 0 0 3 3 2 0 Tetratricopeptide repeat-like domain UCH PF00443.29 EXF83116.1 - 4.9e-25 88.5 0.0 7.4e-25 87.9 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 EXF83116.1 - 2.2e-12 47.1 1.6 3.7e-12 46.4 0.3 1.9 2 0 0 2 2 2 1 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.6 EXF83116.1 - 0.018 14.6 0.0 0.078 12.6 0.0 2.0 2 0 0 2 2 2 0 Ubiquitin carboxyl-terminal hydrolase IF4E PF01652.18 EXF83117.1 - 1.1e-49 168.3 0.1 1.4e-49 167.9 0.1 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E ANAPC3 PF12895.7 EXF83118.1 - 1e-25 89.7 21.3 2.4e-23 82.1 1.1 5.7 4 2 4 8 8 8 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.28 EXF83118.1 - 2.1e-23 81.1 12.2 4.2e-05 23.2 0.9 9.7 10 0 0 10 10 10 4 Tetratricopeptide repeat TPR_19 PF14559.6 EXF83118.1 - 2.9e-22 79.0 19.4 0.00081 19.9 0.0 7.7 5 2 1 7 7 7 6 Tetratricopeptide repeat TPR_2 PF07719.17 EXF83118.1 - 8.5e-21 72.3 24.3 0.0005 20.0 0.4 10.5 12 0 0 12 12 10 5 Tetratricopeptide repeat TPR_8 PF13181.6 EXF83118.1 - 2.8e-18 64.5 5.4 0.0078 16.3 0.3 9.2 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_12 PF13424.6 EXF83118.1 - 5.1e-16 58.7 19.3 0.00034 20.9 0.1 9.0 5 2 3 8 8 8 6 Tetratricopeptide repeat TPR_14 PF13428.6 EXF83118.1 - 8.4e-15 54.2 18.3 0.16 12.9 0.0 9.8 7 4 2 9 9 9 3 Tetratricopeptide repeat TPR_16 PF13432.6 EXF83118.1 - 1e-10 42.1 17.1 0.053 14.2 0.2 8.2 6 3 2 8 8 8 4 Tetratricopeptide repeat TPR_10 PF13374.6 EXF83118.1 - 1.3e-07 31.2 13.4 0.14 12.1 0.0 8.4 9 0 0 9 9 9 2 Tetratricopeptide repeat TPR_6 PF13174.6 EXF83118.1 - 1.9e-06 28.1 11.6 0.49 11.2 0.2 7.8 8 0 0 8 8 7 1 Tetratricopeptide repeat TPR_7 PF13176.6 EXF83118.1 - 3.1e-06 26.8 18.5 9.3 6.5 0.1 8.9 10 0 0 10 10 8 1 Tetratricopeptide repeat TPR_9 PF13371.6 EXF83118.1 - 5.1e-05 23.3 4.3 2.2 8.5 0.2 5.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_15 PF13429.6 EXF83118.1 - 7.6e-05 22.0 6.4 0.19 10.9 0.0 5.4 3 2 0 5 5 5 1 Tetratricopeptide repeat TPR_4 PF07721.14 EXF83118.1 - 0.00031 21.1 3.3 2.2 9.1 0.0 5.8 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_11 PF13414.6 EXF83118.1 - 0.00057 19.5 13.4 1.3 8.8 0.0 6.2 8 0 0 8 8 8 3 TPR repeat Coatomer_E PF04733.14 EXF83118.1 - 0.023 14.1 0.3 19 4.5 0.0 3.8 3 1 0 4 4 4 0 Coatomer epsilon subunit TPR_21 PF09976.9 EXF83118.1 - 0.073 12.8 6.3 1.3 8.6 0.5 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat-like domain Remorin_C PF03763.13 EXF83118.1 - 0.094 12.6 0.3 0.25 11.3 0.3 1.7 1 0 0 1 1 1 0 Remorin, C-terminal region TPR_17 PF13431.6 EXF83118.1 - 0.1 13.0 6.7 74 4.1 0.0 6.9 8 0 0 8 8 8 0 Tetratricopeptide repeat DUF1757 PF08560.10 EXF83119.1 - 0.038 14.1 1.2 0.12 12.4 1.2 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1757) OprD PF03573.13 EXF83119.1 - 0.11 11.5 0.7 0.15 11.1 0.7 1.1 1 0 0 1 1 1 0 outer membrane porin, OprD family TetR_C_14 PF17754.1 EXF83119.1 - 1.8 8.6 7.5 0.32 11.0 0.8 2.1 2 0 0 2 2 2 0 MftR C-terminal domain HET PF06985.11 EXF83120.1 - 6.1e-21 75.3 0.0 1.7e-20 73.9 0.0 1.8 2 0 0 2 2 2 1 Heterokaryon incompatibility protein (HET) AMP-binding PF00501.28 EXF83121.1 - 1.3e-42 145.9 0.0 4.3e-42 144.2 0.0 1.7 1 1 0 1 1 1 1 AMP-binding enzyme ACAS_N PF16177.5 EXF83121.1 - 0.00015 21.6 0.7 0.00028 20.7 0.1 1.9 2 0 0 2 2 2 1 Acetyl-coenzyme A synthetase N-terminus AMP-binding_C PF13193.6 EXF83121.1 - 0.092 13.7 0.0 0.2 12.7 0.0 1.5 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain APG6_N PF17675.1 EXF83122.1 - 0.14 12.7 12.4 0.15 12.6 9.6 2.0 2 0 0 2 2 2 0 Apg6 coiled-coil region PDCD2_C PF04194.13 EXF83122.1 - 3.2 7.8 6.7 45 4.1 0.0 2.2 2 0 0 2 2 2 0 Programmed cell death protein 2, C-terminal putative domain CLIP1_ZNF PF16641.5 EXF83123.1 - 0.1 12.5 4.8 0.2 11.6 4.8 1.5 1 0 0 1 1 1 0 CLIP1 zinc knuckle zf-CCHC PF00098.23 EXF83123.1 - 0.11 12.6 4.1 0.27 11.4 4.1 1.7 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_4 PF14392.6 EXF83123.1 - 0.14 11.9 3.6 0.3 10.9 2.3 2.1 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_6 PF15288.6 EXF83123.1 - 0.31 10.9 6.0 0.11 12.4 3.0 1.8 2 0 0 2 2 2 0 Zinc knuckle PBP1_TM PF14812.6 EXF83124.1 - 1.5 9.3 13.0 0.89 10.0 10.4 2.0 1 1 1 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF4674 PF15719.5 EXF83124.1 - 9.1 6.3 9.4 13 5.8 9.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4674) SlyX PF04102.12 EXF83125.1 - 0.17 12.5 3.7 0.46 11.1 0.7 3.2 2 1 0 2 2 2 0 SlyX Neur_chan_memb PF02932.16 EXF83125.1 - 2.7 8.0 10.5 0.43 10.6 3.4 2.3 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Fungal_trans_2 PF11951.8 EXF83126.1 - 3.9e-41 141.2 0.5 1.2e-40 139.5 0.5 1.7 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF83126.1 - 6.4e-10 39.0 12.1 1.1e-09 38.2 12.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Methyltransf_23 PF13489.6 EXF83127.1 - 6.3e-23 81.4 0.0 9.3e-23 80.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF83127.1 - 8.8e-10 39.2 0.0 4.3e-09 37.0 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF83127.1 - 2.2e-07 31.5 0.0 1.1e-06 29.3 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF83127.1 - 2.3e-06 27.5 0.0 1.6e-05 24.7 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF83127.1 - 7.4e-06 26.5 0.0 1.7e-05 25.3 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 EXF83127.1 - 0.05 13.2 0.0 0.085 12.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain CMAS PF02353.20 EXF83127.1 - 0.086 12.1 0.0 0.2 10.9 0.0 1.5 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_4 PF02390.17 EXF83127.1 - 0.14 11.6 0.0 0.41 10.1 0.0 1.7 2 0 0 2 2 2 0 Putative methyltransferase Methyltransf_2 PF00891.18 EXF83127.1 - 0.16 11.2 0.0 4.1 6.6 0.0 2.4 3 0 0 3 3 3 0 O-methyltransferase domain Methyltransf_16 PF10294.9 EXF83127.1 - 0.22 11.2 0.0 0.33 10.7 0.0 1.2 1 0 0 1 1 1 0 Lysine methyltransferase Fungal_trans PF04082.18 EXF83128.1 - 9e-35 120.0 0.8 9e-35 120.0 0.8 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF83128.1 - 6e-08 32.7 9.6 1.1e-07 31.9 9.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain POT1 PF02765.17 EXF83129.1 - 7.2e-08 32.4 0.0 1.3e-07 31.5 0.0 1.4 1 0 0 1 1 1 1 Telomeric single stranded DNA binding POT1/CDC13 FMO-like PF00743.19 EXF83130.1 - 1.5e-40 139.1 0.0 1.9e-23 82.7 0.0 3.3 3 1 0 3 3 3 3 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EXF83130.1 - 3.6e-16 59.3 0.0 1.6e-09 37.5 0.0 3.3 2 1 1 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EXF83130.1 - 3.1e-13 49.6 0.0 2.2e-12 46.8 0.0 2.3 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EXF83130.1 - 6.5e-11 42.4 0.2 6.3e-06 26.0 0.1 4.0 4 0 0 4 4 4 2 FAD dependent oxidoreductase K_oxygenase PF13434.6 EXF83130.1 - 1.5e-09 37.5 0.0 7.1e-08 32.0 0.0 2.2 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 EXF83130.1 - 2.1e-09 37.6 3.4 1.3e-06 28.4 0.1 4.2 3 2 1 4 4 4 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 EXF83130.1 - 9.3e-09 35.4 0.0 3.3e-07 30.4 0.0 2.7 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 EXF83130.1 - 5.8e-08 32.3 0.1 0.00012 21.5 0.1 2.3 2 0 0 2 2 2 2 Thi4 family FAD_binding_3 PF01494.19 EXF83130.1 - 8.5e-06 25.2 0.1 0.0015 17.9 0.1 2.3 2 0 0 2 2 2 1 FAD binding domain Pyr_redox PF00070.27 EXF83130.1 - 2.2e-05 25.0 0.1 0.19 12.3 0.2 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 EXF83130.1 - 2.9e-05 23.5 0.2 0.0021 17.4 0.0 2.7 3 0 0 3 3 3 1 Flavin containing amine oxidoreductase HI0933_like PF03486.14 EXF83130.1 - 3.4e-05 22.7 0.1 0.046 12.4 0.6 2.5 3 0 0 3 3 3 2 HI0933-like protein Glu_dehyd_C PF16912.5 EXF83130.1 - 0.00014 21.4 0.0 0.28 10.6 0.0 2.2 2 0 0 2 2 2 2 Glucose dehydrogenase C-terminus FAD_binding_2 PF00890.24 EXF83130.1 - 0.0014 17.8 0.3 0.076 12.1 0.2 2.6 3 0 0 3 3 3 1 FAD binding domain Shikimate_DH PF01488.20 EXF83130.1 - 0.0014 18.6 0.0 0.18 11.9 0.0 2.3 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase Lycopene_cycl PF05834.12 EXF83130.1 - 0.0026 16.9 0.1 1.7 7.6 0.0 2.1 2 0 0 2 2 2 2 Lycopene cyclase protein 2-Hacid_dh_C PF02826.19 EXF83130.1 - 0.0045 16.4 0.0 0.78 9.1 0.0 2.2 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TrkA_N PF02254.18 EXF83130.1 - 0.02 15.1 0.1 0.35 11.1 0.1 2.3 2 0 0 2 2 2 0 TrkA-N domain NAD_binding_7 PF13241.6 EXF83130.1 - 0.04 14.3 0.1 5.4 7.5 0.0 2.4 2 1 0 2 2 2 0 Putative NAD(P)-binding IlvN PF07991.12 EXF83130.1 - 0.049 13.2 0.0 0.87 9.1 0.0 2.2 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain FAD_oxidored PF12831.7 EXF83130.1 - 0.2 11.0 0.1 0.4 10.0 0.1 1.5 1 0 0 1 1 1 0 FAD dependent oxidoreductase GIDA PF01134.22 EXF83130.1 - 0.2 10.7 0.1 6.1 5.8 0.2 2.3 3 0 0 3 3 3 0 Glucose inhibited division protein A FGFR3_TM PF18123.1 EXF83130.1 - 0.3 10.6 0.7 0.58 9.7 0.7 1.4 1 0 0 1 1 1 0 Fibroblast growth factor receptor 3 transmembrane domain GAS2 PF02187.17 EXF83131.1 - 1.1e-06 28.6 0.0 2.6e-06 27.4 0.0 1.5 1 0 0 1 1 1 1 Growth-Arrest-Specific Protein 2 Domain Malic_M PF03949.15 EXF83132.1 - 6.6e-93 310.7 0.0 9.1e-93 310.2 0.0 1.2 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 EXF83132.1 - 3.8e-71 238.6 0.0 6.6e-71 237.9 0.0 1.4 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain zf-RING_2 PF13639.6 EXF83133.1 - 9.7e-13 48.2 4.3 1.5e-12 47.6 4.3 1.3 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 EXF83133.1 - 1.4e-10 40.7 1.5 2.8e-10 39.8 1.5 1.5 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 EXF83133.1 - 5.3e-07 29.4 4.1 8.4e-07 28.7 4.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EXF83133.1 - 1.1e-06 28.4 3.2 1.7e-06 27.8 3.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EXF83133.1 - 4.8e-06 26.8 5.4 1.3e-05 25.4 5.4 1.7 1 1 0 1 1 1 1 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 EXF83133.1 - 1.6e-05 24.7 3.5 2.8e-05 23.9 3.5 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EXF83133.1 - 4.8e-05 23.2 1.9 7.9e-05 22.5 1.9 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EXF83133.1 - 0.0028 17.5 2.1 0.0047 16.8 2.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EXF83133.1 - 0.0041 17.1 1.2 0.0079 16.2 1.2 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 EXF83133.1 - 0.006 16.6 5.1 0.012 15.6 5.1 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING-like PF08746.11 EXF83133.1 - 0.051 13.9 2.3 0.081 13.2 2.3 1.3 1 0 0 1 1 1 0 RING-like domain zf-RING_4 PF14570.6 EXF83133.1 - 0.071 12.9 2.5 0.13 12.1 2.5 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain PHD PF00628.29 EXF83133.1 - 0.47 10.4 2.6 0.87 9.5 2.6 1.5 1 0 0 1 1 1 0 PHD-finger FANCL_C PF11793.8 EXF83133.1 - 2.3 8.4 4.0 14 6.0 4.0 2.2 1 1 0 1 1 1 0 FANCL C-terminal domain DUF3602 PF12223.8 EXF83134.1 - 2.8e-14 53.5 5.0 7.5e-12 45.7 0.8 2.8 2 2 1 3 3 3 2 Protein of unknown function (DUF3602) URO-D PF01208.17 EXF83135.1 - 9e-125 416.4 0.0 1e-124 416.2 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen decarboxylase (URO-D) Fungal_trans PF04082.18 EXF83137.1 - 1.1e-08 34.5 0.0 2e-08 33.6 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF83137.1 - 3e-08 33.7 9.1 4.8e-08 33.0 9.1 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SelP_N PF04592.14 EXF83137.1 - 4.2 6.7 5.6 7.3 5.9 5.6 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Fib_alpha PF08702.10 EXF83138.1 - 0.25 11.5 5.7 2.8 8.1 5.7 3.0 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family p450 PF00067.22 EXF83139.1 - 1e-48 166.3 0.0 1.4e-48 165.9 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Fungal_trans PF04082.18 EXF83140.1 - 6.1e-19 68.1 0.0 1.2e-18 67.1 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain P5-ATPase PF12409.8 EXF83140.1 - 0.018 15.2 0.2 0.036 14.2 0.2 1.4 1 0 0 1 1 1 0 P5-type ATPase cation transporter adh_short PF00106.25 EXF83141.1 - 4.3e-35 120.9 0.0 6.2e-35 120.4 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF83141.1 - 3.9e-20 72.4 0.0 5.5e-20 71.9 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF83141.1 - 7e-08 32.6 0.0 1.7e-07 31.3 0.0 1.6 1 1 0 1 1 1 1 KR domain DUF1776 PF08643.10 EXF83141.1 - 8.6e-07 28.6 0.1 1.9e-06 27.5 0.1 1.5 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) 3Beta_HSD PF01073.19 EXF83141.1 - 0.0034 16.4 0.0 0.005 15.9 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EXF83141.1 - 0.014 14.9 0.0 0.02 14.4 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family SLATT_3 PF18184.1 EXF83141.1 - 0.23 11.6 1.3 0.57 10.3 1.3 1.7 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain 3 Abhydrolase_3 PF07859.13 EXF83142.1 - 1.1e-19 71.2 0.5 2.2e-19 70.2 0.5 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 EXF83142.1 - 1.2e-14 54.0 0.0 1.4e-14 53.7 0.0 1.1 1 0 0 1 1 1 1 Steryl acetyl hydrolase Peptidase_S9 PF00326.21 EXF83142.1 - 0.047 13.2 0.0 0.087 12.3 0.0 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family Ammonium_transp PF00909.21 EXF83143.1 - 2.9e-117 391.8 30.9 3.3e-117 391.6 30.9 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family DUF3185 PF11381.8 EXF83143.1 - 6.5 6.9 9.8 8.8 6.4 0.1 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3185) CRT10 PF08728.10 EXF83144.1 - 1.2e-17 63.5 0.0 1.5e-14 53.2 0.0 2.1 2 0 0 2 2 2 2 CRT10 VIR_N PF15912.5 EXF83144.1 - 0.58 9.7 9.5 0.98 9.0 9.5 1.3 1 0 0 1 1 1 0 Virilizer, N-terminal CAP_N PF01213.19 EXF83144.1 - 1.2 8.5 9.0 2 7.9 9.0 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Cellulase PF00150.18 EXF83145.1 - 1.7e-35 122.8 0.1 2.1e-35 122.6 0.1 1.1 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) 7tm_2 PF00002.24 EXF83146.1 - 3.7e-06 26.4 13.1 3.7e-06 26.4 13.1 1.9 1 1 1 2 2 2 1 7 transmembrane receptor (Secretin family) Vma12 PF11712.8 EXF83146.1 - 1.3 9.1 4.2 5.8 7.0 0.4 3.1 3 0 0 3 3 3 0 Endoplasmic reticulum-based factor for assembly of V-ATPase HlyIII PF03006.20 EXF83147.1 - 6.1e-59 199.5 17.5 7.4e-59 199.2 17.5 1.1 1 0 0 1 1 1 1 Haemolysin-III related Ycf66_N PF07444.11 EXF83147.1 - 0.39 10.9 3.4 0.4 10.9 0.9 2.3 2 0 0 2 2 2 0 Ycf66 protein N-terminus FmiP_Thoc5 PF09766.9 EXF83148.1 - 9.4e-33 114.0 7.2 1.4e-32 113.4 7.2 1.2 1 0 0 1 1 1 1 Fms-interacting protein/Thoc5 DUF1664 PF07889.12 EXF83148.1 - 0.063 13.3 1.8 2.4 8.2 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) SPATA1_C PF15743.5 EXF83148.1 - 0.1 12.7 5.0 0.26 11.4 1.2 2.3 2 0 0 2 2 2 0 Spermatogenesis-associated C-terminus DUF1640 PF07798.11 EXF83148.1 - 0.18 11.8 9.5 0.043 13.9 2.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1640) Cnn_1N PF07989.11 EXF83148.1 - 0.22 11.7 6.4 0.52 10.5 0.5 2.6 2 1 0 2 2 2 0 Centrosomin N-terminal motif 1 DUF3450 PF11932.8 EXF83148.1 - 0.28 10.5 10.1 0.048 13.0 3.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) DUF3958 PF13125.6 EXF83148.1 - 0.35 11.1 8.1 2.3 8.5 3.2 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3958) DUF4200 PF13863.6 EXF83148.1 - 0.98 9.8 13.2 0.35 11.3 2.6 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4200) YabA PF06156.13 EXF83148.1 - 1.8 9.3 7.3 3.4 8.3 1.7 2.3 2 0 0 2 2 2 0 Initiation control protein YabA Glyco_trans_2_3 PF13632.6 EXF83149.1 - 5.1e-19 69.0 0.5 1.1e-18 67.9 0.5 1.5 1 0 0 1 1 1 1 Glycosyl transferase family group 2 FKBP_C PF00254.28 EXF83150.1 - 1.1e-30 105.8 0.1 7.9e-30 103.0 0.0 2.3 2 0 0 2 2 2 1 FKBP-type peptidyl-prolyl cis-trans isomerase NPL PF17800.1 EXF83150.1 - 5.2e-30 104.1 1.3 5.2e-30 104.1 1.3 2.9 2 2 0 2 2 2 1 Nucleoplasmin-like domain RNA_polI_A34 PF08208.11 EXF83150.1 - 1.2 9.2 41.2 0.2 11.7 8.6 2.7 2 1 0 2 2 2 0 DNA-directed RNA polymerase I subunit RPA34.5 DMAP1 PF05499.12 EXF83150.1 - 4 7.3 20.1 1.7 8.5 9.1 2.2 2 0 0 2 2 2 0 DNA methyltransferase 1-associated protein 1 (DMAP1) Pkinase PF00069.25 EXF83152.1 - 2e-37 129.0 0.0 1.6e-32 112.9 0.0 2.7 2 1 1 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 EXF83152.1 - 5.7e-15 55.3 0.0 1.1e-14 54.3 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase DUF3905 PF13045.6 EXF83152.1 - 0.014 15.4 1.0 0.16 12.0 0.5 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF3905) APH PF01636.23 EXF83152.1 - 0.053 13.4 0.7 0.15 12.0 0.6 1.6 1 1 0 1 1 1 0 Phosphotransferase enzyme family Exo_endo_phos PF03372.23 EXF83153.1 - 3.6e-14 52.9 0.7 6.6e-14 52.0 0.7 1.5 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family WD40 PF00400.32 EXF83154.1 - 1.1e-54 181.1 18.3 2.2e-10 40.9 0.5 7.6 8 0 0 8 8 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EXF83154.1 - 4.3e-25 87.8 0.0 7.3e-05 23.0 0.0 7.0 3 3 4 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EXF83154.1 - 3.3e-10 39.5 0.2 0.046 12.7 0.0 4.9 2 2 2 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein VID27 PF08553.10 EXF83154.1 - 5.2e-06 25.8 0.0 0.57 9.2 0.0 4.5 3 1 2 5 5 5 2 VID27 C-terminal WD40-like domain Nup160 PF11715.8 EXF83154.1 - 1.6e-05 23.8 1.3 0.42 9.2 0.1 4.4 2 2 1 4 4 4 2 Nucleoporin Nup120/160 eIF2A PF08662.11 EXF83154.1 - 7.2e-05 22.8 0.0 0.0095 15.8 0.0 2.7 3 0 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.16 EXF83154.1 - 0.0014 17.3 0.0 0.041 12.4 0.0 2.4 2 1 1 3 3 3 1 Cytochrome D1 heme domain Frtz PF11768.8 EXF83154.1 - 0.0076 14.6 0.0 0.081 11.2 0.0 2.0 2 0 0 2 2 2 1 WD repeat-containing and planar cell polarity effector protein Fritz Nucleoporin_N PF08801.11 EXF83154.1 - 0.0089 14.8 0.1 0.38 9.4 0.0 3.0 2 1 1 3 3 3 1 Nup133 N terminal like PALB2_WD40 PF16756.5 EXF83154.1 - 0.092 11.6 0.8 6.9 5.5 0.0 3.2 3 1 1 4 4 4 0 Partner and localizer of BRCA2 WD40 domain PD40 PF07676.12 EXF83154.1 - 0.1 12.6 0.1 2.2 8.3 0.1 3.1 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat FSA_C PF10479.9 EXF83154.1 - 1.3 7.0 5.4 2.1 6.4 5.4 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus PPP4R2 PF09184.11 EXF83154.1 - 7.9 6.0 14.6 12 5.4 14.6 1.1 1 0 0 1 1 1 0 PPP4R2 zf-UBR PF02207.20 EXF83155.1 - 5.6e-19 68.1 12.1 1.5e-18 66.7 12.1 1.8 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) ClpS PF02617.17 EXF83155.1 - 1.5e-08 34.3 0.0 3.9e-08 33.0 0.0 1.6 1 0 0 1 1 1 1 ATP-dependent Clp protease adaptor protein ClpS WD40 PF00400.32 EXF83156.1 - 1.7e-15 57.1 13.0 0.00024 21.8 0.0 7.1 7 1 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EXF83156.1 - 5.5e-07 29.8 0.0 0.022 15.1 0.0 4.0 4 1 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 EXF83156.1 - 0.0021 17.9 0.1 4.1 7.4 0.0 3.0 2 0 0 2 2 2 2 WD40-like Beta Propeller Repeat RRM_1 PF00076.22 EXF83157.1 - 2.1e-09 37.1 0.0 6e-09 35.6 0.0 1.8 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EXF83157.1 - 1.5e-06 27.8 0.0 2.5e-06 27.1 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Calcipressin PF04847.12 EXF83157.1 - 0.014 15.1 0.0 0.027 14.2 0.0 1.5 1 0 0 1 1 1 0 Calcipressin Limkain-b1 PF11608.8 EXF83157.1 - 0.021 14.9 0.5 0.046 13.8 0.0 1.7 2 0 0 2 2 2 0 Limkain b1 Autophagy_act_C PF03987.15 EXF83158.1 - 1.2e-13 51.4 0.1 2.4e-13 50.5 0.1 1.5 1 1 1 2 2 2 1 Autophagocytosis associated protein, active-site domain 2-oxoacid_dh PF00198.23 EXF83159.1 - 1e-77 260.7 0.1 1.5e-77 260.2 0.1 1.2 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 EXF83159.1 - 9.2e-18 63.9 3.7 1.7e-17 63.0 3.7 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme HlyD_3 PF13437.6 EXF83159.1 - 0.0014 19.3 0.5 0.08 13.7 0.2 2.3 1 1 1 2 2 2 2 HlyD family secretion protein Biotin_lipoyl_2 PF13533.6 EXF83159.1 - 0.0014 18.4 0.4 0.37 10.7 0.0 2.4 1 1 1 2 2 2 2 Biotin-lipoyl like RnfC_N PF13375.6 EXF83159.1 - 0.065 13.2 1.2 3.3 7.7 0.0 3.1 1 1 2 3 3 3 0 RnfC Barrel sandwich hybrid domain GCV_H PF01597.19 EXF83159.1 - 0.075 12.9 0.2 0.14 12.0 0.2 1.4 1 0 0 1 1 1 0 Glycine cleavage H-protein Trypan_PARP PF05887.11 EXF83159.1 - 0.29 11.1 18.2 0.5 10.3 18.2 1.4 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) FAM76 PF16046.5 EXF83159.1 - 0.53 9.6 6.1 11 5.3 3.3 2.1 2 0 0 2 2 2 0 FAM76 protein Presenilin PF01080.17 EXF83159.1 - 1.1 8.0 3.7 1.5 7.5 3.7 1.1 1 0 0 1 1 1 0 Presenilin Ndc1_Nup PF09531.10 EXF83159.1 - 2.3 6.8 6.4 3.3 6.3 6.4 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup RR_TM4-6 PF06459.12 EXF83159.1 - 9.9 5.9 10.3 14 5.4 10.3 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Glyco_hydro_47 PF01532.20 EXF83160.1 - 1.2e-170 568.4 0.0 1.5e-170 568.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 AA_permease PF00324.21 EXF83161.1 - 9.6e-141 469.6 35.7 1.2e-140 469.3 35.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EXF83161.1 - 5.7e-41 140.7 31.7 7e-41 140.4 31.7 1.1 1 0 0 1 1 1 1 Amino acid permease DUF4781 PF16013.5 EXF83161.1 - 0.095 11.5 2.5 0.13 11.0 0.9 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4781) PknG_TPR PF16918.5 EXF83161.1 - 0.16 10.7 0.2 0.24 10.1 0.2 1.2 1 0 0 1 1 1 0 Protein kinase G tetratricopeptide repeat SnoaL_2 PF12680.7 EXF83162.1 - 0.011 16.3 0.0 0.028 15.1 0.0 1.7 1 0 0 1 1 1 0 SnoaL-like domain adh_short_C2 PF13561.6 EXF83163.1 - 3.3e-57 193.7 0.0 4.4e-57 193.3 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF83163.1 - 7.6e-46 156.0 0.0 1e-45 155.6 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EXF83163.1 - 1e-12 48.4 0.0 1.3e-12 48.0 0.0 1.1 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 EXF83163.1 - 0.013 14.9 0.0 0.016 14.6 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) PALP PF00291.25 EXF83163.1 - 0.041 13.3 0.1 0.057 12.8 0.1 1.2 1 0 0 1 1 1 0 Pyridoxal-phosphate dependent enzyme CbtA PF09490.10 EXF83165.1 - 2.1 8.0 11.7 0.9 9.3 2.2 2.4 2 1 0 2 2 2 0 Probable cobalt transporter subunit (CbtA) DUF2461 PF09365.10 EXF83166.1 - 0.13 12.2 0.0 0.17 11.8 0.0 1.1 1 0 0 1 1 1 0 Conserved hypothetical protein (DUF2461) SWIM PF04434.17 EXF83167.1 - 0.00031 20.3 0.1 0.00062 19.4 0.1 1.4 1 0 0 1 1 1 1 SWIM zinc finger Pkinase_Tyr PF07714.17 EXF83168.1 - 0.0014 17.9 0.2 0.051 12.9 0.1 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 EXF83168.1 - 0.039 13.3 0.0 0.072 12.4 0.0 1.3 1 0 0 1 1 1 0 Protein kinase domain TauD PF02668.16 EXF83171.1 - 9.3e-28 97.8 0.4 1.5e-27 97.1 0.3 1.3 1 1 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family CsiD PF08943.10 EXF83171.1 - 0.024 13.8 0.1 0.038 13.1 0.1 1.2 1 0 0 1 1 1 0 CsiD His_Phos_2 PF00328.22 EXF83173.1 - 3e-51 175.0 0.0 3.5e-51 174.7 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Sulfate_transp PF00916.20 EXF83174.1 - 1.3e-106 356.6 26.3 1.7e-106 356.2 26.3 1.1 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 EXF83174.1 - 7.2e-09 35.3 0.0 1.4e-08 34.4 0.0 1.4 1 0 0 1 1 1 1 STAS domain MFS_MOT1 PF16983.5 EXF83174.1 - 0.0038 17.6 3.4 0.0038 17.6 3.4 3.3 2 1 1 3 3 3 2 Molybdate transporter of MFS superfamily RabGAP-TBC PF00566.18 EXF83175.1 - 1.5e-31 109.8 0.0 3.5e-26 92.2 0.0 2.2 2 0 0 2 2 2 2 Rab-GTPase-TBC domain DUF4072 PF13284.6 EXF83175.1 - 0.019 15.4 1.8 0.14 12.6 1.4 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4072) zf-H2C2_2 PF13465.6 EXF83176.1 - 9.1e-12 44.9 18.1 5.7e-07 29.7 2.5 3.5 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2 PF00096.26 EXF83176.1 - 8.3e-09 35.4 23.6 0.0068 16.8 3.6 3.5 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EXF83176.1 - 1.6e-07 31.5 20.6 0.053 14.4 2.4 3.5 3 0 0 3 3 3 3 C2H2-type zinc finger Rad50_zn_hook PF04423.14 EXF83176.1 - 0.0012 18.6 2.5 0.054 13.3 0.6 2.6 2 0 0 2 2 2 1 Rad50 zinc hook motif zf-C2H2_6 PF13912.6 EXF83176.1 - 0.0017 18.3 17.6 0.098 12.7 0.1 3.4 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_9 PF16293.5 EXF83176.1 - 0.0047 16.7 3.9 1.1 9.1 0.2 3.3 2 1 1 3 3 3 1 C2H2 type zinc-finger (1 copy) ATG16 PF08614.11 EXF83176.1 - 0.007 16.6 0.1 0.007 16.6 0.1 2.6 2 1 1 3 3 3 1 Autophagy protein 16 (ATG16) Zn-ribbon_8 PF09723.10 EXF83176.1 - 0.034 14.3 5.6 0.12 12.6 1.7 2.4 2 0 0 2 2 2 0 Zinc ribbon domain zf-Di19 PF05605.12 EXF83176.1 - 0.15 12.4 10.9 0.38 11.1 6.4 2.3 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding LPP PF04728.13 EXF83176.1 - 0.23 11.9 1.0 3.5 8.1 1.0 2.5 1 1 0 1 1 1 0 Lipoprotein leucine-zipper Macoilin PF09726.9 EXF83176.1 - 0.27 9.8 0.3 0.41 9.1 0.3 1.2 1 0 0 1 1 1 0 Macoilin family DZR PF12773.7 EXF83176.1 - 0.37 10.8 5.2 0.95 9.5 4.8 1.9 1 1 1 2 2 2 0 Double zinc ribbon zf-C2H2_jaz PF12171.8 EXF83176.1 - 0.38 11.1 14.3 5.6 7.4 3.0 4.1 4 1 0 4 4 4 0 Zinc-finger double-stranded RNA-binding FYDLN_acid PF09538.10 EXF83176.1 - 2.1 9.1 7.3 2.7 8.7 1.1 3.0 1 1 1 2 2 2 0 Protein of unknown function (FYDLN_acid) zf-C2HC_2 PF13913.6 EXF83176.1 - 2.7 8.0 7.4 0.15 12.0 0.7 2.2 2 0 0 2 2 2 0 zinc-finger of a C2HC-type Zn_Tnp_IS1595 PF12760.7 EXF83176.1 - 3.3 7.8 7.7 4.6 7.3 2.9 2.3 2 0 0 2 2 2 0 Transposase zinc-ribbon domain GAGA PF09237.11 EXF83176.1 - 3.4 7.6 6.1 11 5.9 0.1 2.8 1 1 2 3 3 3 0 GAGA factor DUF2197 PF09963.9 EXF83176.1 - 4.4 7.6 5.7 1.1 9.6 2.1 1.9 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2197) zf-UDP PF14569.6 EXF83176.1 - 6.7 6.9 7.4 14 5.9 0.3 2.7 1 1 1 2 2 2 0 Zinc-binding RING-finger zf-BED PF02892.15 EXF83176.1 - 8.5 6.5 8.4 6.4 6.9 4.3 2.5 1 1 1 2 2 2 0 BED zinc finger zinc_ribbon_9 PF14369.6 EXF83176.1 - 9.4 6.6 8.0 80 3.6 0.3 3.1 2 1 1 3 3 3 0 zinc-ribbon AAA_13 PF13166.6 EXF83176.1 - 9.8 4.7 6.4 4.5 5.8 0.7 2.0 2 0 0 2 2 2 0 AAA domain SUN PF03856.13 EXF83177.1 - 4.5e-86 288.3 12.1 5.9e-86 287.9 12.1 1.1 1 0 0 1 1 1 1 Beta-glucosidase (SUN family) TALPID3 PF15324.6 EXF83177.1 - 0.25 9.0 13.0 0.35 8.5 13.0 1.2 1 0 0 1 1 1 0 Hedgehog signalling target MFS_1 PF07690.16 EXF83178.1 - 4.2e-14 52.2 10.8 4.2e-14 52.2 10.8 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Hist_deacetyl PF00850.19 EXF83179.1 - 1.9e-77 260.8 0.0 4e-77 259.7 0.0 1.5 2 0 0 2 2 2 1 Histone deacetylase domain Glyco_hydro_114 PF03537.13 EXF83179.1 - 3.4e-59 200.0 0.0 5.1e-59 199.4 0.0 1.3 1 0 0 1 1 1 1 Glycoside-hydrolase family GH114 DUF4648 PF15505.6 EXF83179.1 - 0.17 12.8 0.0 0.56 11.1 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4648) ING PF12998.7 EXF83180.1 - 5.8e-23 81.4 1.9 8.7e-23 80.8 1.9 1.3 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 EXF83180.1 - 0.00017 21.4 9.1 0.00017 21.4 9.1 1.6 2 0 0 2 2 2 1 PHD-finger zf-RING_2 PF13639.6 EXF83180.1 - 0.48 10.8 6.5 0.95 9.8 6.5 1.5 1 0 0 1 1 1 0 Ring finger domain UDPGP PF01704.18 EXF83181.1 - 1.3e-11 43.8 0.1 2.9e-10 39.4 0.0 2.1 1 1 1 2 2 2 2 UTP--glucose-1-phosphate uridylyltransferase DUF3605 PF12239.8 EXF83182.1 - 1.7e-56 190.8 0.1 2.1e-56 190.5 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3605) FolB PF02152.18 EXF83183.1 - 2e-24 86.2 0.0 3.3e-17 63.0 0.0 2.2 2 0 0 2 2 2 2 Dihydroneopterin aldolase ERAP1_C PF11838.8 EXF83184.1 - 4.5e-87 292.5 1.1 1.2e-86 291.1 0.8 1.8 2 0 0 2 2 2 1 ERAP1-like C-terminal domain Peptidase_M1 PF01433.20 EXF83184.1 - 3.5e-83 278.5 0.1 5.5e-83 277.8 0.1 1.3 1 0 0 1 1 1 1 Peptidase family M1 domain Peptidase_M1_N PF17900.1 EXF83184.1 - 4.3e-57 193.3 0.1 4.3e-56 190.1 0.0 2.2 2 0 0 2 2 2 1 Peptidase M1 N-terminal domain Enolase_C PF00113.22 EXF83185.1 - 3.3e-152 505.9 0.2 4.3e-152 505.5 0.2 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.16 EXF83185.1 - 1.2e-58 197.0 0.2 2.2e-58 196.1 0.2 1.5 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.6 EXF83185.1 - 9.7e-06 25.3 0.1 1.9e-05 24.3 0.1 1.4 1 1 0 1 1 1 1 Enolase C-terminal domain-like MAAL_C PF07476.11 EXF83185.1 - 0.049 12.8 0.3 0.67 9.1 0.1 2.4 3 0 0 3 3 3 0 Methylaspartate ammonia-lyase C-terminus PKD_channel PF08016.12 EXF83186.1 - 0.00019 20.3 3.4 0.071 11.8 0.3 2.2 2 0 0 2 2 2 2 Polycystin cation channel Glyco_hydro_67M PF07488.12 EXF83187.1 - 6.9e-140 465.7 0.0 9.9e-140 465.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 67 middle domain Glyco_hydro_67C PF07477.12 EXF83187.1 - 1.3e-89 299.5 1.8 1.9e-89 299.0 1.8 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 67 C-terminus Glyco_hydro_67N PF03648.14 EXF83187.1 - 9.2e-26 90.5 0.0 1.9e-25 89.5 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 67 N-terminus Glyco_hydro_20b PF02838.15 EXF83187.1 - 0.0043 17.8 0.1 0.013 16.3 0.1 1.8 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, domain 2 Ribul_P_3_epim PF00834.19 EXF83187.1 - 0.15 11.4 0.0 0.34 10.3 0.0 1.5 1 0 0 1 1 1 0 Ribulose-phosphate 3 epimerase family FliD_N PF02465.18 EXF83187.1 - 0.22 12.2 0.4 0.44 11.3 0.4 1.4 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus MTS PF05175.14 EXF83188.1 - 0.019 14.5 0.0 0.057 13.0 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase small domain Tyrosinase PF00264.20 EXF83189.1 - 1e-47 163.3 3.9 2.1e-47 162.3 3.9 1.5 1 0 0 1 1 1 1 Common central domain of tyrosinase Tyosinase_C PF18132.1 EXF83189.1 - 5.7e-34 117.4 0.0 1e-33 116.6 0.0 1.4 1 0 0 1 1 1 1 Tyosinase C-terminal domain LSM PF01423.22 EXF83189.1 - 1.5e-16 59.8 0.1 2.4e-16 59.2 0.1 1.3 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EXF83189.1 - 0.081 13.1 0.0 0.19 11.9 0.0 1.5 1 0 0 1 1 1 0 Ataxin 2 SM domain RNA_pol_Rpb2_6 PF00562.28 EXF83190.1 - 4.1e-112 375.1 0.0 5.5e-112 374.7 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 EXF83190.1 - 2e-32 112.4 0.0 3e-32 111.8 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_3 PF04565.16 EXF83190.1 - 8.2e-29 99.6 0.2 2.4e-28 98.1 0.0 2.0 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_2 PF04561.14 EXF83190.1 - 2.2e-26 92.7 0.0 3.5e-26 92.0 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpa2_4 PF06883.12 EXF83190.1 - 1.1e-23 83.0 0.0 2.3e-23 82.0 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase I, Rpa2 specific domain RNA_pol_Rpb2_7 PF04560.20 EXF83190.1 - 5.4e-16 58.8 0.0 1.8e-14 53.9 0.0 2.5 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 7 zinc_ribbon_15 PF17032.5 EXF83190.1 - 0.14 12.9 0.1 0.32 11.8 0.1 1.5 1 0 0 1 1 1 0 zinc-ribbon family Arf PF00025.21 EXF83191.1 - 2e-44 151.1 0.1 2.4e-44 150.9 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 EXF83191.1 - 8.7e-21 74.2 0.0 1e-20 74.0 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EXF83191.1 - 2.5e-16 60.0 0.0 3.6e-16 59.5 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 EXF83191.1 - 6e-08 32.3 0.0 7.8e-08 32.0 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EXF83191.1 - 3.1e-07 30.4 0.0 4.5e-07 30.0 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase G-alpha PF00503.20 EXF83191.1 - 3.9e-06 26.3 0.1 1.3e-05 24.6 0.0 1.9 1 1 1 2 2 2 1 G-protein alpha subunit SRPRB PF09439.10 EXF83191.1 - 8.1e-06 25.4 0.0 9.8e-06 25.1 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 EXF83191.1 - 0.0042 16.7 0.0 0.021 14.4 0.0 1.9 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 EXF83191.1 - 0.0068 16.5 0.1 0.55 10.3 0.1 2.1 1 1 1 2 2 2 1 Dynamin family FeoB_N PF02421.18 EXF83191.1 - 0.034 13.7 0.4 0.067 12.7 0.4 1.7 1 1 0 1 1 1 0 Ferrous iron transport protein B ATP_bind_1 PF03029.17 EXF83191.1 - 0.062 13.1 0.0 0.099 12.4 0.0 1.3 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein PduV-EutP PF10662.9 EXF83191.1 - 0.083 12.6 0.1 2.5 7.8 0.0 2.5 2 1 1 3 3 3 0 Ethanolamine utilisation - propanediol utilisation MMR_HSR1_Xtn PF16897.5 EXF83191.1 - 0.12 12.4 0.0 0.22 11.6 0.0 1.4 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain DUF1979 PF09322.10 EXF83191.1 - 0.17 11.8 0.4 9.8 6.2 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1979) Glyco_transf_17 PF04724.13 EXF83192.1 - 3.2e-51 174.4 0.1 1.6e-50 172.1 0.1 2.0 1 1 0 1 1 1 1 Glycosyltransferase family 17 Beta_elim_lyase PF01212.21 EXF83193.1 - 2.3e-69 233.9 0.0 2.8e-69 233.6 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.21 EXF83193.1 - 8.4e-06 25.2 0.0 1.1e-05 24.9 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EXF83193.1 - 2.6e-05 22.9 0.0 5.3e-05 21.9 0.0 1.4 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 EXF83193.1 - 0.001 18.5 0.5 0.004 16.5 0.5 1.9 1 1 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 EXF83193.1 - 0.097 11.6 0.0 0.14 11.1 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class-V Trehalase PF01204.18 EXF83194.1 - 2.9e-117 392.6 6.4 2e-116 389.9 6.4 1.9 1 1 0 1 1 1 1 Trehalase GDE_C PF06202.14 EXF83194.1 - 2.8e-05 23.2 0.1 7.4e-05 21.8 0.0 1.6 2 0 0 2 2 2 1 Amylo-alpha-1,6-glucosidase RFX5_N PF18326.1 EXF83194.1 - 0.05 13.4 0.1 0.49 10.2 0.0 2.5 3 0 0 3 3 3 0 RFX5 N-terminal domain Band_7 PF01145.25 EXF83195.1 - 2e-23 83.3 2.6 3.7e-23 82.4 2.6 1.5 1 0 0 1 1 1 1 SPFH domain / Band 7 family ubiquitin PF00240.23 EXF83196.1 - 2.1e-18 65.8 0.1 1.1e-17 63.6 0.1 1.8 1 1 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EXF83196.1 - 6.8e-09 35.4 0.0 1.1e-08 34.8 0.0 1.3 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Raf1_HTH PF18579.1 EXF83196.1 - 0.036 13.8 0.0 0.049 13.3 0.0 1.2 1 0 0 1 1 1 0 Rubisco accumulation factor 1 helix turn helix domain Elongin_A PF06881.11 EXF83197.1 - 1.2e-28 99.7 2.0 2.2e-28 98.9 2.0 1.4 1 0 0 1 1 1 1 RNA polymerase II transcription factor SIII (Elongin) subunit A TFIIF_beta_N PF17683.1 EXF83198.1 - 3.6e-32 111.9 0.7 7.7e-32 110.8 0.1 1.8 2 0 0 2 2 2 1 TFIIF, beta subunit N-terminus TFIIF_beta PF02270.15 EXF83198.1 - 2.8e-23 81.8 0.6 5.2e-23 80.9 0.6 1.5 1 0 0 1 1 1 1 TFIIF, beta subunit HTH domain HAD PF12710.7 EXF83199.1 - 2.6e-14 54.1 0.2 1e-13 52.1 0.1 2.0 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EXF83199.1 - 0.047 13.8 0.0 17 5.5 0.0 2.7 2 1 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EXF83199.1 - 0.06 13.6 0.0 0.54 10.5 0.0 2.1 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase K_channel_TID PF07941.11 EXF83201.1 - 0.24 11.9 1.8 0.67 10.4 1.1 1.9 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain PTPA PF03095.15 EXF83203.1 - 2.8e-113 378.4 0.0 3.3e-113 378.1 0.0 1.0 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein RNase_PH PF01138.21 EXF83204.1 - 2e-14 54.2 0.0 3.6e-14 53.4 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 EXF83204.1 - 1.9e-05 24.6 0.0 3.3e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 NAD_kinase PF01513.21 EXF83205.1 - 1.4e-82 277.2 0.0 2.1e-82 276.6 0.0 1.2 1 0 0 1 1 1 1 ATP-NAD kinase Homeodomain PF00046.29 EXF83207.1 - 3.7e-13 49.1 1.0 7.2e-13 48.2 1.0 1.5 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EXF83207.1 - 0.069 13.1 0.2 0.2 11.6 0.2 1.8 1 0 0 1 1 1 0 Homeobox KN domain Ras PF00071.22 EXF83208.1 - 4.4e-49 166.2 0.0 5.3e-49 165.9 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EXF83208.1 - 1.1e-29 103.1 0.1 2.7e-29 101.8 0.0 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EXF83208.1 - 1.7e-10 40.6 0.0 2.1e-10 40.3 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EXF83208.1 - 0.0003 20.9 0.0 0.00055 20.0 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase RNA_helicase PF00910.22 EXF83208.1 - 0.00048 20.5 0.1 0.0029 18.0 0.1 2.1 1 1 0 1 1 1 1 RNA helicase Gtr1_RagA PF04670.12 EXF83208.1 - 0.0029 17.0 0.0 0.0038 16.6 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Pox_A32 PF04665.12 EXF83208.1 - 0.015 14.8 0.1 0.026 14.0 0.1 1.3 1 0 0 1 1 1 0 Poxvirus A32 protein AAA_7 PF12775.7 EXF83208.1 - 0.02 14.4 0.1 0.033 13.7 0.1 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region G-alpha PF00503.20 EXF83208.1 - 0.023 13.9 2.7 0.73 8.9 0.1 2.6 2 1 1 3 3 3 0 G-protein alpha subunit RsgA_GTPase PF03193.16 EXF83208.1 - 0.028 14.3 0.1 8.4 6.3 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase AAA_24 PF13479.6 EXF83208.1 - 0.059 13.1 0.3 0.089 12.5 0.3 1.4 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EXF83208.1 - 0.073 13.4 0.1 0.17 12.3 0.0 1.6 2 0 0 2 2 2 0 AAA ATPase domain SRPRB PF09439.10 EXF83208.1 - 0.081 12.4 0.0 0.14 11.6 0.0 1.4 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit TsaE PF02367.17 EXF83208.1 - 0.099 12.6 0.2 0.23 11.5 0.2 1.6 2 0 0 2 2 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_33 PF13671.6 EXF83208.1 - 0.1 12.8 0.2 0.2 11.8 0.2 1.5 1 0 0 1 1 1 0 AAA domain Septin PF00735.18 EXF83208.1 - 0.15 11.3 0.5 0.22 10.7 0.0 1.6 2 0 0 2 2 2 0 Septin ATPase PF06745.13 EXF83208.1 - 0.21 10.9 0.2 0.31 10.3 0.2 1.2 1 0 0 1 1 1 0 KaiC Nas2_N PF18265.1 EXF83209.1 - 7.6e-13 48.2 2.3 1.5e-08 34.4 0.5 2.2 2 0 0 2 2 2 2 Nas2 N_terminal domain GRASP55_65 PF04495.14 EXF83209.1 - 2.2e-08 34.5 0.0 4.5e-08 33.5 0.0 1.4 1 0 0 1 1 1 1 GRASP55/65 PDZ-like domain PDZ_6 PF17820.1 EXF83209.1 - 1.2e-07 31.5 0.0 2.3e-07 30.5 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 EXF83209.1 - 3.1e-06 27.4 0.0 5.4e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 EXF83209.1 - 0.00034 20.9 0.0 0.0007 19.9 0.0 1.6 1 0 0 1 1 1 1 PDZ domain PWI PF01480.17 EXF83210.1 - 8e-12 45.3 0.3 1.5e-11 44.4 0.3 1.4 1 0 0 1 1 1 1 PWI domain F-box PF00646.33 EXF83211.1 - 0.011 15.6 0.0 0.027 14.3 0.0 1.7 1 0 0 1 1 1 0 F-box domain Ima1_N PF09779.9 EXF83211.1 - 2.2 9.1 5.5 12 6.8 0.0 3.4 4 0 0 4 4 4 0 Ima1 N-terminal domain Dynamin_M PF01031.20 EXF83212.1 - 3.1e-109 364.6 0.0 5.6e-109 363.8 0.0 1.4 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.23 EXF83212.1 - 4.4e-57 192.8 0.0 9e-57 191.8 0.0 1.5 1 0 0 1 1 1 1 Dynamin family GED PF02212.18 EXF83212.1 - 1.6e-30 105.1 1.6 1.6e-30 105.1 1.6 2.2 3 0 0 3 3 3 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 EXF83212.1 - 4.5e-05 23.5 0.3 0.00059 19.9 0.3 2.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase COX17 PF05051.13 EXF83213.1 - 0.0035 17.7 2.0 0.25 11.7 0.2 2.3 1 1 1 2 2 2 2 Cytochrome C oxidase copper chaperone (COX17) CHCH PF06747.13 EXF83213.1 - 0.0055 16.8 0.4 0.016 15.3 0.4 1.8 1 1 1 2 2 2 1 CHCH domain Pet191_N PF10203.9 EXF83213.1 - 0.011 16.0 2.7 0.047 14.0 2.7 1.8 1 1 0 1 1 1 0 Cytochrome c oxidase assembly protein PET191 Cmc1 PF08583.10 EXF83213.1 - 0.027 14.5 1.1 0.078 13.0 1.1 1.7 1 1 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like LIM PF00412.22 EXF83214.1 - 1.6e-24 85.9 22.9 6e-09 36.0 6.1 3.5 3 0 0 3 3 3 3 LIM domain DUF2321 PF10083.9 EXF83214.1 - 0.01 15.5 0.3 0.01 15.5 0.3 3.2 2 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2321) zf-dskA_traR PF01258.17 EXF83214.1 - 0.034 14.1 0.2 0.034 14.1 0.2 5.8 7 0 0 7 7 7 0 Prokaryotic dksA/traR C4-type zinc finger Rad60-SLD PF11976.8 EXF83215.1 - 4.3e-19 68.1 0.1 5e-19 67.9 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 EXF83215.1 - 1.8e-11 43.6 0.1 2.1e-11 43.4 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin family Nup84_Nup100 PF04121.13 EXF83216.1 - 1.5e-197 658.1 0.7 1.8e-197 657.9 0.7 1.0 1 0 0 1 1 1 1 Nuclear pore protein 84 / 107 NopRA1 PF16201.5 EXF83216.1 - 0.06 12.9 0.2 4.7 6.8 0.1 2.5 2 0 0 2 2 2 0 Nucleolar pre-ribosomal-associated protein 1 Mod_r PF07200.13 EXF83217.1 - 2.9e-32 111.8 1.4 3.4e-32 111.6 1.4 1.1 1 0 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein F-box PF00646.33 EXF83219.1 - 4.2e-09 36.1 0.4 1.3e-08 34.5 0.4 1.8 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EXF83219.1 - 1.3e-06 28.2 2.8 2e-06 27.6 0.3 2.7 4 0 0 4 4 4 1 F-box-like V-ATPase_C PF03223.15 EXF83221.1 - 7.1e-125 417.2 0.2 8.3e-125 417.0 0.2 1.0 1 0 0 1 1 1 1 V-ATPase subunit C LemA PF04011.12 EXF83221.1 - 0.028 14.3 0.3 0.061 13.2 0.3 1.6 1 0 0 1 1 1 0 LemA family APS_kinase PF01583.20 EXF83222.1 - 2.4e-72 242.0 0.0 3.6e-72 241.4 0.0 1.2 1 0 0 1 1 1 1 Adenylylsulphate kinase 4HBT PF03061.22 EXF83222.1 - 1.6e-10 41.2 0.0 3.6e-10 40.1 0.0 1.6 1 0 0 1 1 1 1 Thioesterase superfamily AAA_33 PF13671.6 EXF83222.1 - 4.7e-05 23.6 0.0 0.0001 22.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EXF83222.1 - 0.00025 21.6 0.0 0.00048 20.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.10 EXF83222.1 - 0.0062 16.0 0.0 0.0095 15.4 0.0 1.2 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_16 PF13191.6 EXF83222.1 - 0.039 14.3 0.0 0.086 13.2 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain CBF PF03914.17 EXF83224.1 - 6.9e-49 166.1 0.4 6.9e-49 166.1 0.4 2.3 2 0 0 2 2 2 1 CBF/Mak21 family DUF4481 PF14800.6 EXF83224.1 - 0.17 11.3 0.1 0.45 9.9 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4481) Seryl_tRNA_N PF02403.22 EXF83224.1 - 7 6.9 7.0 0.62 10.3 1.0 2.4 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain tRNA-synt_2b PF00587.25 EXF83225.1 - 5.6e-32 111.2 0.0 1.3e-31 109.9 0.0 1.6 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 EXF83225.1 - 1e-11 44.8 0.0 2.4e-11 43.6 0.0 1.6 1 0 0 1 1 1 1 Anticodon binding domain Prefoldin PF02996.17 EXF83226.1 - 3.8e-13 49.4 0.1 4.9e-12 45.8 0.1 2.1 1 1 0 1 1 1 1 Prefoldin subunit CLZ PF16526.5 EXF83226.1 - 0.0085 16.4 4.5 1.1 9.6 0.7 2.2 2 0 0 2 2 2 2 C-terminal leucine zipper domain of cyclic nucleotide-gated channels TACC_C PF05010.14 EXF83226.1 - 0.037 13.8 4.7 0.16 11.7 0.4 2.1 2 0 0 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Fzo_mitofusin PF04799.13 EXF83226.1 - 0.068 12.7 3.9 0.44 10.1 0.5 2.1 2 0 0 2 2 2 0 fzo-like conserved region Trehalose_PPase PF02358.16 EXF83226.1 - 0.13 11.4 1.5 5 6.2 0.0 2.1 2 0 0 2 2 2 0 Trehalose-phosphatase Noelin-1 PF12308.8 EXF83226.1 - 0.34 10.9 3.9 4.4 7.4 0.5 2.1 2 0 0 2 2 2 0 Neurogenesis glycoprotein GIT_CC PF16559.5 EXF83226.1 - 0.38 10.6 6.2 0.3 11.0 2.3 2.2 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor UDG PF03167.19 EXF83227.1 - 0.00028 20.9 0.0 0.0015 18.6 0.0 1.9 2 0 0 2 2 2 1 Uracil DNA glycosylase superfamily Mito_carr PF00153.27 EXF83228.1 - 1.2e-61 204.6 3.8 1.6e-20 72.9 0.1 4.1 3 1 0 3 3 3 3 Mitochondrial carrier protein F-box-like PF12937.7 EXF83229.1 - 2.4e-09 37.0 0.0 5.3e-09 35.8 0.0 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EXF83229.1 - 0.016 15.1 0.0 0.036 13.9 0.0 1.6 1 0 0 1 1 1 0 F-box domain adh_short PF00106.25 EXF83230.1 - 2.9e-35 121.5 1.3 3.9e-33 114.6 1.3 2.1 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF83230.1 - 7.1e-23 81.4 1.0 2.3e-21 76.4 1.0 2.1 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF83230.1 - 4.7e-12 46.2 0.3 6.6e-12 45.7 0.3 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EXF83230.1 - 0.0051 16.3 0.4 0.015 14.8 0.4 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family EzrA PF06160.12 EXF83231.1 - 0.022 13.0 1.8 0.035 12.3 1.8 1.2 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA DivIVA PF05103.13 EXF83231.1 - 0.21 11.7 1.9 0.59 10.2 1.1 2.0 1 1 0 1 1 1 0 DivIVA protein MBOAT PF03062.19 EXF83233.1 - 7e-50 170.3 14.6 7e-50 170.3 14.6 1.9 2 0 0 2 2 2 1 MBOAT, membrane-bound O-acyltransferase family Asn_synthase PF00733.21 EXF83234.1 - 3.7e-64 217.6 0.0 5.2e-64 217.1 0.0 1.2 1 0 0 1 1 1 1 Asparagine synthase GATase_7 PF13537.6 EXF83234.1 - 2.8e-35 120.9 0.0 5.1e-35 120.1 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 EXF83234.1 - 3.8e-33 114.5 0.0 9.1e-33 113.3 0.0 1.7 1 0 0 1 1 1 1 Glutamine amidotransferase domain DUF3700 PF12481.8 EXF83234.1 - 1.6e-06 27.7 0.0 3.7e-06 26.6 0.0 1.5 1 0 0 1 1 1 1 Aluminium induced protein NAD_synthase PF02540.17 EXF83234.1 - 0.054 12.6 0.0 0.089 11.9 0.0 1.3 1 0 0 1 1 1 0 NAD synthase tRNA_Me_trans PF03054.16 EXF83234.1 - 0.15 10.8 0.0 0.23 10.2 0.0 1.2 1 0 0 1 1 1 0 tRNA methyl transferase Amidohydro_2 PF04909.14 EXF83235.1 - 1.2e-25 91.0 0.9 2.4e-25 89.9 0.9 1.5 1 1 0 1 1 1 1 Amidohydrolase Spt5-NGN PF03439.13 EXF83235.1 - 0.099 12.5 0.0 0.22 11.4 0.0 1.5 1 0 0 1 1 1 0 Early transcription elongation factor of RNA pol II, NGN section PAM2 PF07145.15 EXF83236.1 - 0.0021 17.6 9.2 0.78 9.6 0.1 3.8 3 0 0 3 3 3 3 Ataxin-2 C-terminal region AIM24 PF01987.17 EXF83237.1 - 2.5e-51 174.4 0.7 3e-51 174.1 0.7 1.1 1 0 0 1 1 1 1 Mitochondrial biogenesis AIM24 Aldedh PF00171.22 EXF83238.1 - 1.4e-12 46.9 11.5 3.1e-08 32.6 0.6 3.0 3 0 0 3 3 3 3 Aldehyde dehydrogenase family URO-D PF01208.17 EXF83238.1 - 0.025 13.7 0.1 0.13 11.4 0.0 1.9 1 1 1 2 2 2 0 Uroporphyrinogen decarboxylase (URO-D) MFS_1 PF07690.16 EXF83239.1 - 4.2e-43 147.6 42.6 4.2e-43 147.6 42.6 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF83239.1 - 7.1e-07 28.4 14.4 7.1e-07 28.4 14.4 2.6 2 1 0 2 2 2 1 Sugar (and other) transporter PTR2 PF00854.21 EXF83239.1 - 0.00058 18.8 5.1 0.015 14.1 1.3 2.5 1 1 1 3 3 3 2 POT family IDO PF01231.18 EXF83240.1 - 2.3e-35 122.2 0.0 3.1e-35 121.8 0.0 1.1 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase Pes-10 PF07149.11 EXF83241.1 - 1.2 8.1 2.6 1.9 7.5 2.6 1.2 1 0 0 1 1 1 0 Pes-10 INO80_Ies4 PF08193.11 EXF83242.1 - 1.6e-81 273.9 15.7 2.1e-81 273.5 15.7 1.1 1 0 0 1 1 1 1 INO80 complex subunit Ies4 CLTH PF10607.9 EXF83243.1 - 9.7e-32 109.9 0.0 1.8e-31 109.1 0.0 1.4 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain SPRY PF00622.28 EXF83243.1 - 1.2e-24 86.7 0.2 2.1e-24 85.9 0.2 1.4 1 0 0 1 1 1 1 SPRY domain LisH PF08513.11 EXF83243.1 - 5e-06 26.3 0.4 1.2e-05 25.1 0.1 1.9 2 0 0 2 2 2 1 LisH MFS_1 PF07690.16 EXF83244.1 - 3.8e-27 95.2 44.5 6.3e-21 74.7 30.4 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Nodulin-like PF06813.13 EXF83244.1 - 0.0014 18.2 4.8 0.0014 18.2 4.8 2.1 1 1 0 2 2 2 1 Nodulin-like DUF2178 PF09946.9 EXF83244.1 - 5.5 7.2 8.3 0.63 10.2 0.2 3.2 3 0 0 3 3 3 0 Predicted membrane protein (DUF2178) LAM_C PF12544.8 EXF83245.1 - 0.00019 21.6 0.1 0.00043 20.5 0.1 1.5 1 0 0 1 1 1 1 Lysine-2,3-aminomutase TFIIA PF03153.13 EXF83246.1 - 0.036 14.1 9.3 0.057 13.4 9.3 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RNB PF00773.19 EXF83248.1 - 3.6e-54 184.3 0.0 6.5e-54 183.5 0.0 1.4 1 0 0 1 1 1 1 RNB domain Rhomboid PF01694.22 EXF83249.1 - 1.9e-22 79.9 14.5 1.9e-22 79.9 14.5 2.1 1 1 1 2 2 2 1 Rhomboid family Flavodoxin_4 PF12682.7 EXF83250.1 - 0.053 13.2 0.0 0.33 10.7 0.0 1.9 2 0 0 2 2 2 0 Flavodoxin BSP_II PF05432.11 EXF83250.1 - 0.065 12.9 3.3 0.094 12.4 3.3 1.3 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) PepSY_2 PF13670.6 EXF83251.1 - 0.11 12.6 0.1 8.4 6.5 0.0 2.4 2 0 0 2 2 2 0 Peptidase propeptide and YPEB domain IU_nuc_hydro PF01156.19 EXF83253.1 - 6.4e-55 186.9 0.0 1.1e-54 186.0 0.0 1.3 1 1 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase LSM PF01423.22 EXF83254.1 - 2.2e-16 59.3 0.0 2.8e-16 59.0 0.0 1.2 1 0 0 1 1 1 1 LSM domain NINJA_B PF16136.5 EXF83255.1 - 0.055 13.8 0.3 0.14 12.6 0.3 1.7 1 0 0 1 1 1 0 Putative nuclear localisation signal HECT_2 PF09814.9 EXF83256.1 - 5e-98 328.4 0.0 5.7e-98 328.2 0.0 1.0 1 0 0 1 1 1 1 HECT-like Ubiquitin-conjugating enzyme (E2)-binding Kelch_6 PF13964.6 EXF83257.1 - 9.9e-07 28.8 2.2 0.11 12.8 0.0 4.7 4 0 0 4 4 4 2 Kelch motif Glycophorin_A PF01102.18 EXF83257.1 - 0.00014 22.1 1.0 0.00038 20.7 1.0 1.7 1 0 0 1 1 1 1 Glycophorin A Podoplanin PF05808.11 EXF83257.1 - 0.00089 19.4 3.4 0.003 17.7 2.9 2.2 2 0 0 2 2 2 1 Podoplanin TMEM154 PF15102.6 EXF83257.1 - 0.004 17.1 2.4 0.016 15.1 2.4 1.9 1 1 0 1 1 1 1 TMEM154 protein family RIFIN PF02009.16 EXF83257.1 - 0.0099 15.8 0.0 0.016 15.1 0.0 1.2 1 0 0 1 1 1 1 Rifin Amnionless PF14828.6 EXF83257.1 - 0.033 13.0 0.1 0.052 12.4 0.1 1.3 1 0 0 1 1 1 0 Amnionless CD34_antigen PF06365.12 EXF83257.1 - 0.04 13.5 2.8 0.23 11.0 0.1 2.2 1 1 1 2 2 2 0 CD34/Podocalyxin family Apt1 PF10351.9 EXF83257.1 - 0.11 11.4 1.9 0.17 10.7 1.9 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain Mid2 PF04478.12 EXF83257.1 - 0.17 11.7 0.0 0.17 11.7 0.0 2.3 2 0 0 2 2 2 0 Mid2 like cell wall stress sensor AJAP1_PANP_C PF15298.6 EXF83257.1 - 0.27 11.4 6.6 0.66 10.2 6.6 1.6 1 0 0 1 1 1 0 AJAP1/PANP C-terminus Plasmodium_Vir PF05795.11 EXF83257.1 - 0.33 10.3 0.4 0.51 9.7 0.4 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein RAP1 PF07218.11 EXF83257.1 - 9.4 4.4 19.0 14 3.8 19.0 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) TAP_C PF03943.13 EXF83259.1 - 8.3e-19 67.0 0.1 1.4e-18 66.2 0.1 1.4 1 0 0 1 1 1 1 TAP C-terminal domain LRR_4 PF12799.7 EXF83259.1 - 2.1e-09 37.5 5.9 5.3e-06 26.7 0.9 2.9 1 1 2 3 3 3 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EXF83259.1 - 3.9e-06 26.5 0.2 1.2e-05 25.0 0.2 1.9 1 0 0 1 1 1 1 Leucine rich repeat NTF2 PF02136.20 EXF83259.1 - 1.7e-05 25.4 0.0 4e-05 24.2 0.0 1.7 1 1 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain RRM_9 PF18444.1 EXF83259.1 - 3.5e-05 23.6 0.1 0.00012 21.8 0.1 1.9 1 1 0 1 1 1 1 RNA recognition motif LRR_9 PF14580.6 EXF83259.1 - 0.00024 20.7 0.1 0.00044 19.8 0.1 1.3 1 0 0 1 1 1 1 Leucine-rich repeat LRR_1 PF00560.33 EXF83259.1 - 0.027 15.0 0.3 13 6.8 0.0 3.6 2 0 0 2 2 2 0 Leucine Rich Repeat LRR_6 PF13516.6 EXF83259.1 - 0.11 12.6 3.3 1.1 9.5 0.2 3.3 3 0 0 3 3 3 0 Leucine Rich repeat ResIII PF04851.15 EXF83260.1 - 1.6e-24 86.8 0.0 4.6e-24 85.3 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EXF83260.1 - 9.6e-22 77.4 0.1 2.2e-21 76.3 0.1 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EXF83260.1 - 3.2e-17 62.8 0.1 4.3e-16 59.2 0.0 2.8 4 0 0 4 4 4 1 DEAD/DEAH box helicase SWI2_SNF2 PF18766.1 EXF83260.1 - 1.7e-05 24.6 0.0 4.2e-05 23.3 0.0 1.6 1 0 0 1 1 1 1 SWI2/SNF2 ATPase FANCM-MHF_bd PF16783.5 EXF83260.1 - 0.0025 17.9 0.1 0.0051 16.9 0.1 1.5 1 0 0 1 1 1 1 FANCM to MHF binding domain AAA_22 PF13401.6 EXF83260.1 - 0.011 16.0 0.0 0.046 14.0 0.0 2.1 1 1 0 1 1 1 0 AAA domain TSP_3 PF02412.18 EXF83260.1 - 1.8 8.3 5.7 5.4 6.8 5.7 1.9 1 0 0 1 1 1 0 Thrombospondin type 3 repeat Fungal_trans PF04082.18 EXF83261.1 - 5.3e-10 38.8 0.0 9e-10 38.0 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF83261.1 - 4.9e-07 29.8 12.4 8.5e-07 29.0 12.4 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Torus PF16131.5 EXF83262.1 - 3.3 8.5 8.5 0.18 12.5 0.4 2.5 2 0 0 2 2 2 0 Torus domain Dynactin PF12455.8 EXF83263.1 - 3.4e-111 371.1 10.7 3.4e-111 371.1 10.7 4.8 4 1 1 5 5 5 1 Dynein associated protein CAP_GLY PF01302.25 EXF83263.1 - 1e-22 79.9 0.4 1.8e-22 79.1 0.4 1.4 1 0 0 1 1 1 1 CAP-Gly domain DUF2353 PF09789.9 EXF83263.1 - 6.4e-06 25.8 26.4 6.4e-06 25.8 26.4 4.6 3 2 2 5 5 5 2 Uncharacterized coiled-coil protein (DUF2353) HMG_box PF00505.19 EXF83264.1 - 3.2e-11 43.5 0.0 8.3e-11 42.1 0.0 1.7 1 0 0 1 1 1 1 HMG (high mobility group) box DUF1272 PF06906.11 EXF83264.1 - 0.1 12.7 0.2 0.19 11.8 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) TIP49 PF06068.13 EXF83265.1 - 2.4e-167 556.5 0.2 2.9e-167 556.2 0.2 1.1 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 EXF83265.1 - 9.5e-26 89.7 0.1 2.2e-25 88.5 0.1 1.7 1 0 0 1 1 1 1 TIP49 AAA-lid domain AAA PF00004.29 EXF83265.1 - 8.7e-12 45.6 0.2 3.3e-07 30.8 0.1 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EXF83265.1 - 2.8e-09 36.9 0.1 1.4e-06 28.2 0.0 2.5 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EXF83265.1 - 0.00016 22.0 0.2 0.28 11.4 0.0 2.5 2 1 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EXF83265.1 - 0.00078 19.9 0.1 0.0063 16.9 0.1 2.2 1 1 0 1 1 1 1 AAA ATPase domain AAA_19 PF13245.6 EXF83265.1 - 0.0014 19.0 1.8 0.16 12.3 0.3 2.4 2 1 0 2 2 2 1 AAA domain AAA_28 PF13521.6 EXF83265.1 - 0.0014 18.9 0.1 0.0033 17.7 0.1 1.6 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.6 EXF83265.1 - 0.0071 15.9 0.1 0.047 13.3 0.1 2.1 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 EXF83265.1 - 0.0076 16.2 0.1 0.21 11.6 0.1 2.4 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 EXF83265.1 - 0.01 16.4 0.0 0.028 14.9 0.0 1.8 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 EXF83265.1 - 0.02 14.3 0.2 0.59 9.5 0.1 2.2 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.12 EXF83265.1 - 0.025 13.9 0.2 0.066 12.5 0.1 1.7 2 0 0 2 2 2 0 Zeta toxin DnaB_C PF03796.15 EXF83265.1 - 0.032 13.6 0.0 0.068 12.5 0.0 1.5 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain Sigma54_activat PF00158.26 EXF83265.1 - 0.035 13.8 0.1 2 8.1 0.1 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain IstB_IS21 PF01695.17 EXF83265.1 - 0.049 13.4 0.2 0.11 12.2 0.2 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_7 PF12775.7 EXF83265.1 - 0.074 12.6 0.1 0.21 11.1 0.0 1.7 2 0 0 2 2 2 0 P-loop containing dynein motor region DUF2075 PF09848.9 EXF83265.1 - 0.1 11.8 0.2 0.22 10.7 0.0 1.5 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_33 PF13671.6 EXF83265.1 - 0.16 12.1 0.0 0.48 10.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain EamA PF00892.20 EXF83266.1 - 7.3e-21 74.8 24.7 6.6e-11 42.5 3.3 2.1 2 0 0 2 2 2 2 EamA-like transporter family UAA PF08449.11 EXF83266.1 - 0.012 14.9 1.5 0.036 13.3 1.5 1.8 1 0 0 1 1 1 0 UAA transporter family TFIID-18kDa PF02269.16 EXF83267.1 - 2.7e-18 65.7 0.0 4.3e-18 65.1 0.0 1.2 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit Bromo_TP PF07524.13 EXF83267.1 - 0.0001 22.2 0.0 0.00018 21.5 0.0 1.4 1 0 0 1 1 1 1 Bromodomain associated CBFD_NFYB_HMF PF00808.23 EXF83267.1 - 0.0035 17.6 0.8 0.017 15.4 0.0 2.2 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-S PF15630.6 EXF83267.1 - 0.0061 16.9 0.0 0.011 16.1 0.0 1.4 1 0 0 1 1 1 1 CENP-S protein Histone PF00125.24 EXF83267.1 - 0.024 15.0 0.4 0.094 13.1 0.0 2.0 2 0 0 2 2 2 0 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 EXF83267.1 - 0.11 12.6 0.1 0.25 11.5 0.0 1.6 1 1 1 2 2 2 0 Centromere kinetochore component CENP-T histone fold DUF1242 PF06842.12 EXF83268.1 - 3e-19 68.5 0.4 4e-19 68.1 0.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1242) Sigma_M_inh PF17453.2 EXF83268.1 - 0.033 14.6 0.2 0.04 14.4 0.2 1.1 1 0 0 1 1 1 0 Sigma-M inhibitor UbiA PF01040.18 EXF83268.1 - 0.059 12.7 0.2 0.062 12.6 0.2 1.0 1 0 0 1 1 1 0 UbiA prenyltransferase family WBP-1 PF11669.8 EXF83268.1 - 0.19 12.4 2.9 0.29 11.8 2.8 1.5 1 1 0 1 1 1 0 WW domain-binding protein 1 Tcp11 PF05794.13 EXF83269.1 - 4.3e-104 349.1 0.0 7e-104 348.4 0.0 1.3 1 1 0 1 1 1 1 T-complex protein 11 DUF3584 PF12128.8 EXF83269.1 - 0.084 10.4 0.0 0.13 9.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) CENP-U PF13097.6 EXF83269.1 - 8 6.4 6.0 60 3.5 0.0 2.4 2 0 0 2 2 2 0 CENP-A nucleosome associated complex (NAC) subunit Uds1 PF15456.6 EXF83270.1 - 2.4e-38 131.2 8.2 2.4e-38 131.2 8.2 7.5 4 2 2 6 6 6 2 Up-regulated During Septation APG6_N PF17675.1 EXF83270.1 - 8.6e-05 23.1 2.3 8.6e-05 23.1 2.3 9.2 4 2 5 9 9 9 2 Apg6 coiled-coil region UPF0242 PF06785.11 EXF83270.1 - 0.00067 19.8 2.6 0.00067 19.8 2.6 7.0 4 2 1 7 7 7 2 Uncharacterised protein family (UPF0242) N-terminus HR1 PF02185.16 EXF83270.1 - 0.004 17.2 6.2 0.004 17.2 6.2 10.7 6 3 6 12 12 12 2 Hr1 repeat TMF_DNA_bd PF12329.8 EXF83270.1 - 0.0064 16.5 5.7 0.0064 16.5 5.7 11.5 7 2 4 12 12 12 3 TATA element modulatory factor 1 DNA binding Rab5-bind PF09311.11 EXF83270.1 - 0.0068 15.8 10.2 0.0068 15.8 10.2 7.1 4 1 1 6 6 6 1 Rabaptin-like protein ATG16 PF08614.11 EXF83270.1 - 0.0074 16.5 30.6 0.0074 16.5 30.6 7.7 3 2 2 7 7 7 3 Autophagy protein 16 (ATG16) Fez1 PF06818.15 EXF83270.1 - 0.0082 16.6 22.9 0.0082 16.6 22.9 6.5 2 1 4 6 6 6 2 Fez1 MOSC PF03473.17 EXF83270.1 - 0.093 12.7 1.3 0.55 10.3 0.1 2.8 2 1 0 2 2 2 0 MOSC domain DUF1751 PF08551.10 EXF83271.1 - 8.1e-05 23.1 0.1 0.00015 22.2 0.1 1.4 1 0 0 1 1 1 1 Eukaryotic integral membrane protein (DUF1751) Rhomboid PF01694.22 EXF83271.1 - 0.0066 16.5 3.1 0.014 15.4 3.1 1.5 1 1 0 1 1 1 1 Rhomboid family Prenyltransf PF01255.19 EXF83272.1 - 9.1e-83 277.2 0.0 1.3e-82 276.6 0.0 1.2 1 0 0 1 1 1 1 Putative undecaprenyl diphosphate synthase MSA-2c PF12238.8 EXF83272.1 - 0.067 13.2 0.3 0.096 12.7 0.3 1.2 1 0 0 1 1 1 0 Merozoite surface antigen 2c ING PF12998.7 EXF83273.1 - 1e-07 32.4 0.0 0.00092 19.8 0.0 2.4 2 0 0 2 2 2 2 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 EXF83273.1 - 1.1e-05 25.2 7.0 1.8e-05 24.5 7.0 1.4 1 0 0 1 1 1 1 PHD-finger zf-HC5HC2H PF13771.6 EXF83273.1 - 0.11 12.8 1.5 0.24 11.7 1.5 1.6 1 0 0 1 1 1 0 PHD-like zinc-binding domain PHD_2 PF13831.6 EXF83273.1 - 0.55 9.8 3.1 1 9.0 3.1 1.4 1 0 0 1 1 1 0 PHD-finger LRR_6 PF13516.6 EXF83274.1 - 0.00097 19.0 0.4 2.7 8.3 0.0 5.1 6 0 0 6 6 6 1 Leucine Rich repeat LRR_4 PF12799.7 EXF83274.1 - 0.014 15.8 2.8 0.23 11.9 0.0 4.2 4 1 1 5 5 5 0 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EXF83274.1 - 0.03 14.1 3.0 1.4 8.8 0.0 3.8 5 0 0 5 5 5 0 Leucine rich repeat F-box-like PF12937.7 EXF83274.1 - 0.037 13.9 0.0 0.12 12.3 0.0 2.0 1 0 0 1 1 1 0 F-box-like Ribosomal_S19e PF01090.19 EXF83275.1 - 0.019 14.6 0.0 0.038 13.7 0.0 1.4 1 1 0 1 1 1 0 Ribosomal protein S19e GRAB PF10375.9 EXF83276.1 - 2.4e-09 36.7 0.1 5.7e-09 35.5 0.1 1.7 1 0 0 1 1 1 1 GRIP-related Arf-binding domain Spc7 PF08317.11 EXF83276.1 - 5.5e-05 22.2 56.8 6.3e-05 22.0 28.1 2.6 1 1 1 2 2 2 2 Spc7 kinetochore protein Filament PF00038.21 EXF83276.1 - 9.6e-05 22.1 54.0 0.019 14.5 26.8 2.2 1 1 1 2 2 2 2 Intermediate filament protein IFT57 PF10498.9 EXF83276.1 - 0.0011 18.0 17.3 0.0011 18.0 17.3 2.4 1 1 1 2 2 2 1 Intra-flagellar transport protein 57 T3SSipB PF16535.5 EXF83276.1 - 0.0018 18.7 13.2 0.0018 18.7 13.2 3.3 1 1 1 2 2 2 1 Type III cell invasion protein SipB DUF5101 PF17031.5 EXF83276.1 - 0.0071 16.4 0.9 0.0071 16.4 0.9 4.8 3 1 2 6 6 5 1 Domain of unknown function (DUF5101) JIP_LZII PF16471.5 EXF83276.1 - 0.011 15.9 2.4 0.011 15.9 2.4 6.2 4 2 1 6 6 6 0 JNK-interacting protein leucine zipper II Fib_alpha PF08702.10 EXF83276.1 - 0.011 15.9 34.4 0.49 10.6 3.4 4.2 1 1 3 4 4 4 0 Fibrinogen alpha/beta chain family TPR_MLP1_2 PF07926.12 EXF83276.1 - 0.012 15.7 13.9 0.012 15.7 13.9 4.7 2 2 2 4 4 4 0 TPR/MLP1/MLP2-like protein CENP-F_leu_zip PF10473.9 EXF83276.1 - 0.012 15.6 27.7 0.012 15.6 27.7 3.2 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ADIP PF11559.8 EXF83276.1 - 0.013 15.6 13.0 0.013 15.6 13.0 3.7 1 1 3 4 4 4 0 Afadin- and alpha -actinin-Binding HALZ PF02183.18 EXF83276.1 - 0.042 14.1 2.2 0.042 14.1 2.2 4.9 4 1 0 4 4 4 0 Homeobox associated leucine zipper Golgin_A5 PF09787.9 EXF83276.1 - 0.065 12.7 58.4 0.078 12.4 29.6 3.2 1 1 2 3 3 3 0 Golgin subfamily A member 5 DUF1664 PF07889.12 EXF83276.1 - 0.11 12.5 30.9 0.64 10.1 2.1 4.2 1 1 4 5 5 5 0 Protein of unknown function (DUF1664) Occludin_ELL PF07303.13 EXF83276.1 - 0.13 13.0 31.5 0.45 11.3 5.1 4.2 1 1 2 4 4 4 0 Occludin homology domain Seryl_tRNA_N PF02403.22 EXF83276.1 - 0.17 12.1 48.5 0.05 13.8 11.9 5.0 1 1 3 4 4 4 0 Seryl-tRNA synthetase N-terminal domain DUF745 PF05335.13 EXF83276.1 - 0.35 10.6 46.2 0.34 10.6 11.9 3.2 1 1 2 3 3 3 0 Protein of unknown function (DUF745) GAS PF13851.6 EXF83276.1 - 0.38 10.1 56.6 0.53 9.6 9.1 4.0 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding Rootletin PF15035.6 EXF83276.1 - 1.5 8.8 52.7 0.35 10.9 27.5 3.0 2 1 1 3 3 3 0 Ciliary rootlet component, centrosome cohesion ZYG-11_interact PF05884.12 EXF83276.1 - 2 7.8 14.4 4.5 6.6 2.8 2.9 2 1 0 2 2 2 0 Interactor of ZYG-11 Atg14 PF10186.9 EXF83276.1 - 2.3 7.2 48.2 0.11 11.5 21.6 3.0 1 1 1 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF641 PF04859.12 EXF83276.1 - 2.5 8.5 42.0 4.2 7.7 11.4 4.1 2 2 1 3 3 3 0 Plant protein of unknown function (DUF641) DUF3584 PF12128.8 EXF83276.1 - 2.5 5.5 53.0 7.3 4.0 52.0 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) DUF4201 PF13870.6 EXF83276.1 - 2.5 7.8 47.0 0.053 13.2 10.1 4.1 1 1 3 4 4 4 0 Domain of unknown function (DUF4201) DUF4407 PF14362.6 EXF83276.1 - 2.8 7.2 45.2 1.8 7.8 20.8 3.1 1 1 1 2 2 1 0 Domain of unknown function (DUF4407) Fez1 PF06818.15 EXF83276.1 - 3.2 8.2 57.2 0.36 11.3 21.2 3.5 1 1 2 3 3 3 0 Fez1 Baculo_PEP_C PF04513.12 EXF83276.1 - 4 7.5 21.4 0.49 10.4 1.9 3.8 1 1 3 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus ATG16 PF08614.11 EXF83276.1 - 4.4 7.5 73.5 3.7 7.7 13.1 4.4 1 1 3 4 4 4 0 Autophagy protein 16 (ATG16) NPV_P10 PF05531.12 EXF83276.1 - 5.5 7.5 19.4 0.38 11.3 1.2 4.6 2 2 2 4 4 4 0 Nucleopolyhedrovirus P10 protein YkyA PF10368.9 EXF83276.1 - 5.7 6.6 46.5 0.45 10.2 16.8 2.9 1 1 2 3 3 3 0 Putative cell-wall binding lipoprotein APG17 PF04108.12 EXF83276.1 - 6.2 5.8 41.0 0.93 8.5 10.8 3.7 1 1 3 4 4 4 0 Autophagy protein Apg17 TolA_bind_tri PF16331.5 EXF83276.1 - 6.7 6.9 38.2 0.17 12.0 3.3 4.8 2 2 2 4 4 4 0 TolA binding protein trimerisation Prominin PF05478.11 EXF83276.1 - 7.7 4.3 28.1 3.5 5.5 13.3 2.4 1 1 1 2 2 2 0 Prominin Laminin_II PF06009.12 EXF83276.1 - 9.4 6.3 41.0 1.6 8.7 4.5 4.1 2 2 2 4 4 4 0 Laminin Domain II RRM_1 PF00076.22 EXF83277.1 - 1.9e-12 46.8 0.0 4.8e-12 45.5 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EXF83277.1 - 0.00081 19.0 0.0 0.0015 18.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SMN PF06003.12 EXF83278.1 - 2.7e-06 26.8 13.5 4.3e-05 22.9 0.7 2.9 1 1 2 3 3 3 2 Survival motor neuron protein (SMN) Cu_bind_like PF02298.17 EXF83279.1 - 0.044 13.8 0.0 0.13 12.3 0.0 1.7 1 1 0 1 1 1 0 Plastocyanin-like domain DUF2057 PF09829.9 EXF83279.1 - 5.2 7.2 9.4 2 8.5 1.0 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2057) 4F5 PF04419.14 EXF83280.1 - 9.8e-11 42.4 15.8 9.8e-11 42.4 15.8 2.3 2 1 0 2 2 2 1 4F5 protein family DFRP_C PF16543.5 EXF83280.1 - 0.9 10.1 8.0 1.4 9.4 8.0 1.4 1 1 0 1 1 1 0 DRG Family Regulatory Proteins, Tma46 PUF PF00806.19 EXF83281.1 - 1.5e-58 191.3 10.8 1.7e-07 30.5 0.0 8.5 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat DUF2054 PF10218.9 EXF83281.1 - 0.14 12.2 1.6 1.1 9.3 0.8 2.4 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2054) TMCO5 PF14992.6 EXF83282.1 - 0.074 12.6 3.5 0.11 12.1 3.5 1.2 1 0 0 1 1 1 0 TMCO5 family Poxvirus_B22R PF04395.12 EXF83283.1 - 0.078 12.5 0.2 0.078 12.5 0.2 1.7 2 0 0 2 2 2 0 Poxvirus B22R protein RNA_pol_Rpb2_6 PF00562.28 EXF83284.1 - 4e-121 404.7 0.0 6.3e-121 404.1 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 EXF83284.1 - 2.4e-54 184.0 0.2 4.1e-54 183.2 0.2 1.3 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_7 PF04560.20 EXF83284.1 - 1.1e-33 115.4 0.5 2.8e-33 114.2 0.5 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_2 PF04561.14 EXF83284.1 - 1.9e-30 105.9 0.1 4.1e-30 104.8 0.1 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_4 PF04566.13 EXF83284.1 - 3.1e-22 78.6 0.2 7.7e-22 77.3 0.2 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_3 PF04565.16 EXF83284.1 - 2.4e-19 69.3 0.0 4.8e-19 68.3 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.17 EXF83284.1 - 3.2e-10 40.4 2.4 1.1e-09 38.6 2.4 2.0 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 5 MMU163 PF17119.5 EXF83285.1 - 1.8e-71 240.2 4.4 4.5e-52 176.7 0.6 2.1 1 1 1 2 2 2 2 Mitochondrial protein up-regulated during meiosis Tom5 PF10642.9 EXF83285.1 - 0.45 10.6 0.1 0.45 10.6 0.1 2.3 2 0 0 2 2 2 0 Mitochondrial import receptor subunit or translocase MFS_1 PF07690.16 EXF83287.1 - 2.4e-34 118.8 52.1 3.9e-29 101.7 15.3 2.7 2 1 0 3 3 3 2 Major Facilitator Superfamily TRI12 PF06609.13 EXF83287.1 - 2.3e-08 32.9 11.7 2.3e-08 32.9 11.7 1.7 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) MFS_2 PF13347.6 EXF83287.1 - 0.00015 20.5 2.9 0.00015 20.5 2.9 3.1 3 1 0 3 3 3 2 MFS/sugar transport protein DUF4552 PF15089.6 EXF83288.1 - 0.19 10.8 0.0 0.25 10.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4552) Carn_acyltransf PF00755.20 EXF83290.1 - 3.1e-209 696.5 0.0 2.9e-208 693.2 0.0 1.9 1 1 0 1 1 1 1 Choline/Carnitine o-acyltransferase Yip1 PF04893.17 EXF83291.1 - 0.1 12.3 0.0 0.18 11.5 0.0 1.3 1 0 0 1 1 1 0 Yip1 domain Rad51 PF08423.11 EXF83292.1 - 2e-40 138.7 0.0 1.5e-39 135.8 0.0 1.9 1 1 0 1 1 1 1 Rad51 AAA_25 PF13481.6 EXF83292.1 - 4e-07 29.8 0.0 9.3e-07 28.6 0.0 1.6 1 1 0 1 1 1 1 AAA domain RecA PF00154.21 EXF83292.1 - 2.8e-06 27.0 0.0 0.00014 21.4 0.0 2.1 2 0 0 2 2 2 1 recA bacterial DNA recombination protein ATPase PF06745.13 EXF83292.1 - 5.2e-06 26.0 0.0 1e-05 25.0 0.0 1.5 1 0 0 1 1 1 1 KaiC Pox_A32 PF04665.12 EXF83292.1 - 0.099 12.1 0.1 0.17 11.3 0.1 1.3 1 0 0 1 1 1 0 Poxvirus A32 protein AAA_24 PF13479.6 EXF83292.1 - 0.12 12.1 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EXF83292.1 - 0.13 12.5 0.0 0.36 11.1 0.0 1.9 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EXF83292.1 - 0.19 12.2 0.1 0.35 11.4 0.1 1.4 1 0 0 1 1 1 0 ABC transporter Ras PF00071.22 EXF83293.1 - 5.7e-23 81.3 0.3 6.6e-23 81.1 0.3 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EXF83293.1 - 0.0025 18.0 0.2 0.0062 16.8 0.1 1.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase WD40 PF00400.32 EXF83295.1 - 4.6e-12 46.2 7.7 0.011 16.6 0.0 6.1 6 0 0 6 6 6 3 WD domain, G-beta repeat Sigma70_r1_2 PF00140.20 EXF83295.1 - 0.0094 15.9 1.1 0.026 14.5 0.7 2.0 2 0 0 2 2 2 1 Sigma-70 factor, region 1.2 SGL PF08450.12 EXF83295.1 - 0.058 13.0 0.1 0.21 11.2 0.1 1.9 3 0 0 3 3 3 0 SMP-30/Gluconolactonase/LRE-like region PQQ_3 PF13570.6 EXF83295.1 - 0.46 11.0 2.7 4.4 7.9 0.1 3.8 5 0 0 5 5 5 0 PQQ-like domain Mcl1_mid PF12341.8 EXF83296.1 - 9.1e-100 333.8 0.0 4.8e-98 328.2 0.0 2.5 3 0 0 3 3 3 1 Minichromosome loss protein, Mcl1, middle region WD40 PF00400.32 EXF83296.1 - 1.3e-21 76.4 0.6 4.2e-08 33.7 0.0 7.1 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EXF83296.1 - 4.3e-19 68.6 0.0 9.6e-05 22.6 0.1 7.4 2 1 6 8 8 8 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EXF83296.1 - 3.7e-05 23.7 0.1 0.00033 20.6 0.2 2.3 1 1 1 2 2 2 1 Eukaryotic translation initiation factor eIF2A Coatomer_WDAD PF04053.14 EXF83296.1 - 5.6e-05 22.4 0.0 0.00042 19.5 0.0 1.9 1 1 1 2 2 2 1 Coatomer WD associated region Ge1_WD40 PF16529.5 EXF83296.1 - 0.0034 16.4 0.1 3 6.7 0.0 2.9 2 1 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein MMS1_N PF10433.9 EXF83296.1 - 0.05 12.2 0.0 2.4 6.7 0.0 2.4 1 1 0 2 2 2 0 Mono-functional DNA-alkylating methyl methanesulfonate N-term SH3_15 PF18346.1 EXF83296.1 - 0.078 13.3 0.1 0.81 10.0 0.0 2.4 2 0 0 2 2 2 0 Mind bomb SH3 repeat domain KTSC PF13619.6 EXF83296.1 - 0.09 12.6 0.0 4.4 7.2 0.0 2.6 2 0 0 2 2 2 0 KTSC domain WD40_3 PF15911.5 EXF83296.1 - 0.098 12.7 0.0 2 8.5 0.0 2.9 3 0 0 3 3 3 0 WD domain, G-beta repeat PQQ_3 PF13570.6 EXF83296.1 - 2 9.0 6.4 19 5.9 0.0 4.8 5 1 0 5 5 5 0 PQQ-like domain HSF_DNA-bind PF00447.17 EXF83297.1 - 1.2e-29 102.7 0.6 2.1e-29 102.0 0.6 1.4 1 0 0 1 1 1 1 HSF-type DNA-binding AP3D1 PF06375.11 EXF83298.1 - 1.2 9.3 26.1 0.71 10.1 10.6 2.4 1 1 1 2 2 2 0 AP-3 complex subunit delta-1 Hamartin PF04388.12 EXF83298.1 - 4 6.0 17.6 4.9 5.7 17.6 1.1 1 0 0 1 1 1 0 Hamartin protein HET PF06985.11 EXF83299.1 - 6.7e-34 117.3 0.6 1.1e-33 116.7 0.6 1.3 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Methyltransf_23 PF13489.6 EXF83301.1 - 1.9e-08 34.3 0.0 2.7e-08 33.8 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF83301.1 - 0.00082 19.2 0.0 0.0021 17.9 0.0 1.8 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF83301.1 - 0.0035 17.9 0.0 0.0081 16.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain NICE-3 PF07406.11 EXF83303.1 - 0.00035 20.6 2.6 0.016 15.2 0.0 2.5 3 0 0 3 3 3 2 NICE-3 protein DUF4129 PF13559.6 EXF83303.1 - 0.001 19.3 1.1 0.0016 18.6 0.1 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4129) MASE3 PF17159.4 EXF83303.1 - 0.086 12.5 2.6 0.13 11.8 2.6 1.2 1 0 0 1 1 1 0 Membrane-associated sensor domain Na_Ca_ex PF01699.24 EXF83303.1 - 0.17 11.8 3.4 0.28 11.1 3.4 1.2 1 0 0 1 1 1 0 Sodium/calcium exchanger protein DUF3537 PF12056.8 EXF83303.1 - 1.4 7.7 3.5 2.1 7.1 3.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3537) Ndc1_Nup PF09531.10 EXF83304.1 - 1.7e-199 664.5 2.6 1.9e-199 664.4 2.6 1.0 1 0 0 1 1 1 1 Nucleoporin protein Ndc1-Nup Syntaxin_2 PF14523.6 EXF83305.1 - 1.3e-25 89.7 5.9 1.3e-25 89.7 5.9 2.5 2 1 0 2 2 2 1 Syntaxin-like protein SNARE PF05739.19 EXF83305.1 - 2e-13 50.1 1.3 2e-13 50.1 1.3 2.2 2 0 0 2 2 2 1 SNARE domain Syntaxin PF00804.25 EXF83305.1 - 0.00066 19.4 13.7 0.0023 17.6 13.7 1.9 1 1 0 1 1 1 1 Syntaxin Synaptobrevin PF00957.21 EXF83305.1 - 0.023 14.5 0.6 0.023 14.5 0.6 2.1 2 0 0 2 2 2 0 Synaptobrevin DUF883 PF05957.13 EXF83305.1 - 0.087 13.4 14.0 0.4 11.3 0.1 3.4 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF883) DUF1664 PF07889.12 EXF83305.1 - 0.092 12.8 11.8 3.8 7.6 0.6 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) MCPsignal PF00015.21 EXF83305.1 - 0.12 12.2 12.4 1.6 8.5 3.6 3.2 1 1 3 4 4 4 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Occludin_ELL PF07303.13 EXF83305.1 - 0.84 10.4 4.8 1.1 10.1 0.6 2.8 2 1 1 3 3 3 0 Occludin homology domain Spectrin PF00435.21 EXF83305.1 - 0.92 10.0 12.2 6.5 7.3 2.2 3.2 2 1 1 3 3 3 0 Spectrin repeat T2SSF PF00482.23 EXF83305.1 - 1.6 8.7 4.9 0.47 10.4 1.0 2.2 2 1 0 2 2 2 0 Type II secretion system (T2SS), protein F LPP PF04728.13 EXF83305.1 - 2.8 8.4 9.1 8.7 6.8 0.0 3.9 3 1 0 3 3 3 0 Lipoprotein leucine-zipper T3SSipB PF16535.5 EXF83305.1 - 5.2 7.5 13.6 1.1 9.7 6.0 2.6 3 0 0 3 3 3 0 Type III cell invasion protein SipB 60KD_IMP PF02096.20 EXF83306.1 - 0.00043 20.2 0.0 0.0008 19.4 0.0 1.6 1 1 0 1 1 1 1 60Kd inner membrane protein ALG11_N PF15924.5 EXF83307.1 - 1.2e-85 286.8 0.2 7.6e-85 284.2 0.0 2.1 2 0 0 2 2 2 1 ALG11 mannosyltransferase N-terminus Glycos_transf_1 PF00534.20 EXF83307.1 - 2.7e-22 79.1 0.0 4.8e-22 78.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EXF83307.1 - 1e-11 45.4 0.0 2.1e-11 44.4 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 EXF83307.1 - 0.0029 17.6 0.0 0.0049 16.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase Family 4 DAHP_synth_1 PF00793.20 EXF83307.1 - 0.1 11.5 0.0 0.15 10.9 0.0 1.2 1 0 0 1 1 1 0 DAHP synthetase I family G_glu_transpept PF01019.21 EXF83308.1 - 1.3e-164 548.8 0.0 1.5e-164 548.6 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase DUF2520 PF10728.9 EXF83308.1 - 0.15 11.9 0.0 4.7 7.0 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF2520) tRNA_U5-meth_tr PF05958.11 EXF83309.1 - 1.7e-14 53.6 0.0 4.1e-13 49.0 0.0 2.4 2 1 0 2 2 2 1 tRNA (Uracil-5-)-methyltransferase Methyltransf_15 PF09445.10 EXF83309.1 - 4.9e-07 29.5 0.0 9e-07 28.6 0.0 1.4 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_25 PF13649.6 EXF83309.1 - 0.00015 22.4 0.0 0.0004 21.0 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF83309.1 - 0.00024 20.9 0.0 0.00052 19.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF83309.1 - 0.0061 17.2 0.0 0.019 15.6 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EXF83309.1 - 0.0099 15.3 0.0 0.017 14.5 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltrans_SAM PF10672.9 EXF83309.1 - 0.034 13.3 0.0 0.054 12.7 0.0 1.2 1 0 0 1 1 1 0 S-adenosylmethionine-dependent methyltransferase TRM PF02005.16 EXF83309.1 - 0.035 13.3 0.1 0.11 11.7 0.0 1.7 2 0 0 2 2 2 0 N2,N2-dimethylguanosine tRNA methyltransferase Methyltransf_12 PF08242.12 EXF83309.1 - 0.037 14.7 0.0 0.18 12.5 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase domain Cons_hypoth95 PF03602.15 EXF83309.1 - 0.081 12.6 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 95 MTS PF05175.14 EXF83309.1 - 0.11 12.0 0.0 0.24 10.9 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase small domain UNC45-central PF11701.8 EXF83310.1 - 2.4e-56 189.9 0.1 1.8e-55 187.1 0.1 2.4 2 0 0 2 2 2 1 Myosin-binding striated muscle assembly central HEAT PF02985.22 EXF83310.1 - 0.0098 16.1 5.1 9.5 6.8 0.1 5.6 4 0 0 4 4 4 1 HEAT repeat DUF5631 PF18645.1 EXF83310.1 - 0.067 13.6 0.3 0.35 11.3 0.1 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5631) HEAT_2 PF13646.6 EXF83310.1 - 10 6.6 24.7 1.8 9.0 4.1 6.1 4 1 3 7 7 7 0 HEAT repeats Tfb4 PF03850.14 EXF83311.1 - 5e-96 321.4 0.3 5.9e-96 321.2 0.3 1.0 1 0 0 1 1 1 1 Transcription factor Tfb4 Asparaginase_2 PF01112.18 EXF83312.1 - 3.4e-46 157.7 2.7 5.5e-30 104.4 0.0 2.2 2 0 0 2 2 2 2 Asparaginase Actin PF00022.19 EXF83313.1 - 1.3e-88 297.4 0.0 1.3e-52 178.8 0.0 2.0 1 1 1 2 2 2 2 Actin ADH_N PF08240.12 EXF83314.1 - 4.8e-28 97.2 0.3 9.2e-28 96.3 0.3 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EXF83314.1 - 1.1e-24 86.9 0.1 1.8e-24 86.2 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EXF83314.1 - 0.00019 22.5 0.0 0.00029 21.9 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase adh_short PF00106.25 EXF83314.1 - 0.043 13.3 0.3 0.092 12.2 0.3 1.6 1 0 0 1 1 1 0 short chain dehydrogenase 2-Hacid_dh_C PF02826.19 EXF83314.1 - 0.05 13.0 0.2 0.12 11.7 0.2 1.6 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain p450 PF00067.22 EXF83316.1 - 1.1e-65 222.3 0.0 1.4e-65 221.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 WD40 PF00400.32 EXF83317.1 - 6.4e-08 33.1 17.2 0.0015 19.3 0.2 7.3 8 0 0 8 8 8 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EXF83317.1 - 6.9e-05 23.1 0.1 9.4 6.6 0.0 5.7 3 2 3 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain HET PF06985.11 EXF83318.1 - 7.6e-28 97.7 0.0 1.1e-27 97.1 0.0 1.3 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Reovirus_cap PF00979.17 EXF83318.1 - 0.028 13.6 1.4 0.046 12.9 1.4 1.3 1 0 0 1 1 1 0 Reovirus outer capsid protein, Sigma 3 Alpha-L-AF_C PF06964.12 EXF83319.1 - 2.5e-19 70.0 0.0 5.5e-19 68.9 0.0 1.5 1 0 0 1 1 1 1 Alpha-L-arabinofuranosidase C-terminal domain SnoaL PF07366.12 EXF83321.1 - 5.7e-16 58.5 0.0 9.2e-16 57.8 0.0 1.3 1 0 0 1 1 1 1 SnoaL-like polyketide cyclase SnoaL_2 PF12680.7 EXF83321.1 - 0.0016 19.0 0.0 0.004 17.8 0.0 1.8 1 0 0 1 1 1 1 SnoaL-like domain Fasciclin PF02469.22 EXF83323.1 - 1.4e-35 122.3 0.9 1.7e-23 83.2 0.4 2.1 2 0 0 2 2 2 2 Fasciclin domain SelB-wing_2 PF09106.11 EXF83323.1 - 0.18 12.1 0.0 0.37 11.0 0.0 1.5 1 0 0 1 1 1 0 Elongation factor SelB, winged helix Peptidase_S41 PF03572.18 EXF83324.1 - 5.5e-07 29.3 0.0 1.2e-06 28.2 0.0 1.5 1 1 0 1 1 1 1 Peptidase family S41 DUF1772 PF08592.11 EXF83325.1 - 1.2e-19 70.9 0.2 1.2e-19 70.9 0.2 1.9 1 1 1 2 2 2 1 Domain of unknown function (DUF1772) Vps62 PF06101.11 EXF83326.1 - 5.2e-06 25.0 0.1 6.1e-06 24.8 0.1 1.3 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 62 Ceramidase PF05875.12 EXF83327.1 - 2.1e-100 335.5 16.6 2.4e-100 335.3 16.6 1.0 1 0 0 1 1 1 1 Ceramidase COX2_TM PF02790.15 EXF83327.1 - 1.6 8.9 7.3 0.14 12.3 0.9 2.5 3 0 0 3 3 3 0 Cytochrome C oxidase subunit II, transmembrane domain DUF3180 PF11377.8 EXF83327.1 - 5.1 7.2 6.3 14 5.9 1.4 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3180) TMEM208_SND2 PF05620.11 EXF83327.1 - 6.1 6.6 6.6 1 9.2 0.2 2.6 1 1 2 3 3 3 0 SRP-independent targeting protein 2/TMEM208 CobD_Cbib PF03186.13 EXF83328.1 - 0.039 13.2 1.1 0.065 12.4 0.3 1.8 1 1 1 2 2 2 0 CobD/Cbib protein DnaJ PF00226.31 EXF83331.1 - 4.5e-19 68.3 2.4 6.8e-19 67.8 2.4 1.3 1 0 0 1 1 1 1 DnaJ domain DUF456 PF04306.13 EXF83331.1 - 0.0095 16.2 0.7 0.017 15.4 0.7 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF456) Bacteriocin_IIc PF10439.9 EXF83331.1 - 0.012 15.7 2.7 0.028 14.5 2.1 1.9 2 0 0 2 2 2 0 Bacteriocin class II with double-glycine leader peptide TIP_N PF12457.8 EXF83331.1 - 0.022 15.1 2.5 0.04 14.3 1.9 1.8 2 0 0 2 2 2 0 Tuftelin interacting protein N terminal PT-VENN PF04829.13 EXF83331.1 - 1.7 8.8 4.8 1.7 8.8 1.7 2.4 3 0 0 3 3 3 0 Pre-toxin domain with VENN motif Peptidase_M13_N PF05649.13 EXF83332.1 - 4e-67 227.6 0.0 5.1e-67 227.2 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M13 Peptidase_M13 PF01431.21 EXF83332.1 - 1.9e-58 197.4 0.6 3.3e-58 196.7 0.6 1.4 1 0 0 1 1 1 1 Peptidase family M13 Ank_5 PF13857.6 EXF83333.1 - 0.17 12.3 0.0 0.35 11.3 0.0 1.5 1 0 0 1 1 1 0 Ankyrin repeats (many copies) Ank_2 PF12796.7 EXF83335.1 - 8e-15 55.2 0.0 7.6e-08 32.8 0.0 3.6 4 1 0 4 4 4 2 Ankyrin repeats (3 copies) Ank PF00023.30 EXF83335.1 - 1e-14 54.2 1.3 0.0042 17.5 0.0 5.6 5 0 0 5 5 5 3 Ankyrin repeat Ank_4 PF13637.6 EXF83335.1 - 1.1e-14 54.5 0.0 0.0046 17.5 0.0 5.2 5 0 0 5 5 5 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EXF83335.1 - 4.2e-11 42.0 0.3 0.00045 20.5 0.0 5.1 5 0 0 5 5 5 2 Ankyrin repeat Ank_5 PF13857.6 EXF83335.1 - 6.5e-08 32.7 0.1 0.00069 19.9 0.0 3.8 4 0 0 4 4 4 2 Ankyrin repeats (many copies) F-box_4 PF15966.5 EXF83335.1 - 0.031 14.2 0.0 0.063 13.2 0.0 1.4 1 0 0 1 1 1 0 F-box LSM PF01423.22 EXF83339.1 - 9.1e-18 63.7 0.0 1.4e-17 63.1 0.0 1.2 1 0 0 1 1 1 1 LSM domain Ribosomal_L5_C PF00673.21 EXF83340.1 - 1.9e-22 79.2 0.0 2.8e-22 78.7 0.0 1.3 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 EXF83340.1 - 8.6e-20 70.8 0.0 3.2e-19 69.0 0.0 1.9 2 0 0 2 2 2 1 Ribosomal protein L5 ATP-synt_ab PF00006.25 EXF83341.1 - 1.2e-73 247.4 0.0 1.7e-73 246.8 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.27 EXF83341.1 - 4.9e-47 159.4 0.2 8.7e-47 158.6 0.2 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.23 EXF83341.1 - 4.4e-15 55.9 3.0 1.1e-14 54.7 3.0 1.7 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain RbcS PF12338.8 EXF83341.1 - 0.094 12.9 0.5 1.6 8.9 0.4 2.7 2 0 0 2 2 2 0 Ribulose-1,5-bisphosphate carboxylase small subunit Carb_kinase PF01256.17 EXF83342.1 - 1.5e-54 185.1 0.1 2.2e-54 184.5 0.1 1.2 1 0 0 1 1 1 1 Carbohydrate kinase Pico_P1A PF02226.16 EXF83342.1 - 0.029 14.4 0.3 0.54 10.3 0.2 2.4 2 0 0 2 2 2 0 Picornavirus coat protein (VP4) MPC PF03650.13 EXF83343.1 - 1.1e-35 122.1 0.0 1.3e-35 121.8 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers MtrG PF04210.13 EXF83343.1 - 0.12 12.3 0.2 0.18 11.6 0.2 1.3 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, subunit G CPSase_L_D2 PF02786.17 EXF83344.1 - 2.9e-81 272.0 0.4 4.5e-81 271.4 0.4 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain PYC_OADA PF02436.18 EXF83344.1 - 8e-69 231.4 0.0 1.4e-68 230.6 0.0 1.4 1 0 0 1 1 1 1 Conserved carboxylase domain Biotin_carb_N PF00289.22 EXF83344.1 - 1e-38 132.3 0.1 2.1e-38 131.3 0.1 1.5 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 EXF83344.1 - 2.5e-32 111.2 0.0 1e-31 109.2 0.0 2.1 2 0 0 2 2 1 1 Biotin carboxylase C-terminal domain HMGL-like PF00682.19 EXF83344.1 - 5.8e-26 91.6 0.0 1.3e-25 90.5 0.0 1.5 1 0 0 1 1 1 1 HMGL-like Biotin_lipoyl PF00364.22 EXF83344.1 - 4.1e-19 68.2 3.5 8.6e-19 67.2 1.8 2.5 2 0 0 2 2 2 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 EXF83344.1 - 1.3e-10 40.9 1.9 2.2e-06 27.4 0.1 3.3 2 1 1 3 3 3 2 Biotin-lipoyl like Dala_Dala_lig_C PF07478.13 EXF83344.1 - 7.1e-10 38.8 0.0 1.4e-09 37.8 0.0 1.4 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 EXF83344.1 - 7.5e-08 32.1 0.1 1.5e-07 31.1 0.1 1.4 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.14 EXF83344.1 - 7.3e-05 22.9 0.0 0.00018 21.6 0.0 1.7 1 0 0 1 1 1 1 ATP-grasp domain RimK PF08443.11 EXF83344.1 - 0.00027 20.6 0.0 0.0013 18.4 0.0 1.9 1 1 0 1 1 1 1 RimK-like ATP-grasp domain HlyD_D23 PF16576.5 EXF83344.1 - 0.00088 18.5 0.1 0.17 11.1 0.0 2.4 1 1 1 2 2 2 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion HlyD_3 PF13437.6 EXF83344.1 - 0.0017 19.1 0.3 4 8.2 0.0 3.3 3 0 0 3 3 3 1 HlyD family secretion protein ATPgrasp_ST PF14397.6 EXF83344.1 - 0.0037 16.6 0.0 0.01 15.1 0.0 1.7 1 0 0 1 1 1 1 Sugar-transfer associated ATP-grasp DUF2118 PF09891.9 EXF83344.1 - 0.0077 16.2 0.0 0.077 12.9 0.1 2.4 2 0 0 2 2 2 1 Uncharacterized protein conserved in archaea (DUF2118) ATP-grasp_4 PF13535.6 EXF83344.1 - 0.0094 15.6 0.0 0.024 14.3 0.0 1.7 1 0 0 1 1 1 1 ATP-grasp domain GARS_A PF01071.19 EXF83344.1 - 0.036 13.8 0.0 0.1 12.4 0.0 1.7 2 0 0 2 2 1 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ATPgrasp_YheCD PF14398.6 EXF83344.1 - 0.064 12.5 0.0 2.7 7.2 0.0 2.2 2 0 0 2 2 2 0 YheC/D like ATP-grasp NQRA PF05896.11 EXF83344.1 - 0.073 12.5 0.2 0.13 11.7 0.2 1.3 1 0 0 1 1 1 0 Na(+)-translocating NADH-quinone reductase subunit A (NQRA) GCV_H PF01597.19 EXF83344.1 - 0.17 11.8 1.0 0.59 10.0 0.2 2.3 2 0 0 2 2 2 0 Glycine cleavage H-protein RnfC_N PF13375.6 EXF83344.1 - 0.22 11.5 2.0 0.29 11.1 0.4 2.0 2 0 0 2 2 2 0 RnfC Barrel sandwich hybrid domain Proteasome PF00227.26 EXF83345.1 - 5.6e-46 156.4 0.0 3.8e-30 104.8 0.0 2.2 1 1 1 2 2 2 2 Proteasome subunit Proteasome_A_N PF10584.9 EXF83345.1 - 4.7e-12 45.3 1.0 5.6e-12 45.1 0.0 1.7 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature CBP4 PF07960.11 EXF83346.1 - 0.23 11.3 10.8 0.16 11.8 6.6 2.6 2 1 1 3 3 3 0 CBP4 MAJIN PF15077.6 EXF83346.1 - 0.58 9.9 3.5 1.1 9.0 3.3 1.5 1 1 0 1 1 1 0 Membrane-anchored junction protein DUF3169 PF11368.8 EXF83347.1 - 1 8.9 7.2 2.4 7.6 0.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3169) DnaJ PF00226.31 EXF83348.1 - 4.1e-10 39.6 2.1 8e-10 38.7 0.2 2.3 3 0 0 3 3 3 1 DnaJ domain SirA PF10747.9 EXF83348.1 - 0.025 14.9 0.2 0.042 14.2 0.2 1.3 1 0 0 1 1 1 0 Sporulation inhibitor of replication protein SirA zf-RING_2 PF13639.6 EXF83350.1 - 0.0031 17.8 7.4 0.0031 17.8 7.4 3.2 3 1 0 3 3 3 1 Ring finger domain zf-RING_5 PF14634.6 EXF83350.1 - 0.012 15.6 1.7 0.027 14.4 1.7 1.7 1 0 0 1 1 1 0 zinc-RING finger domain Chisel PF15355.6 EXF83350.1 - 0.18 12.1 0.0 0.53 10.6 0.0 1.7 2 0 0 2 2 2 0 Stretch-responsive small skeletal muscle X protein, Chisel RINGv PF12906.7 EXF83350.1 - 0.26 11.4 4.9 0.76 10.0 4.9 1.9 1 0 0 1 1 1 0 RING-variant domain zf-C3HC4_3 PF13920.6 EXF83350.1 - 0.27 11.1 7.4 1.6 8.7 5.2 2.7 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) FANCL_C PF11793.8 EXF83350.1 - 5 7.4 8.9 1.3 9.3 4.5 2.3 2 1 0 2 2 2 0 FANCL C-terminal domain DNA_pol_phi PF04931.13 EXF83352.1 - 3.1e-184 614.2 16.4 3.1e-184 614.2 16.4 1.4 2 0 0 2 2 2 1 DNA polymerase phi Rhodanese PF00581.20 EXF83353.1 - 1e-13 51.7 0.0 2e-13 50.8 0.0 1.4 1 0 0 1 1 1 1 Rhodanese-like domain Glyco_tranf_2_3 PF13641.6 EXF83354.1 - 4.3e-22 79.1 0.0 5.7e-22 78.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 EXF83354.1 - 6.4e-06 25.8 0.0 1.6e-05 24.5 0.0 1.7 1 1 0 1 1 1 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.26 EXF83354.1 - 0.00017 21.5 0.0 0.00054 19.8 0.0 1.8 2 0 0 2 2 2 1 Glycosyl transferase family 2 Dimerisation PF08100.11 EXF83355.1 - 0.073 13.1 0.0 0.13 12.3 0.0 1.5 1 0 0 1 1 1 0 Dimerisation domain DUF4423 PF14394.6 EXF83355.1 - 0.11 12.2 0.0 0.86 9.3 0.0 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4423) Peptidase_A22B PF04258.13 EXF83356.1 - 2.4e-59 201.2 8.2 2e-38 132.6 2.3 2.3 2 1 0 2 2 2 2 Signal peptide peptidase Pro_isomerase PF00160.21 EXF83357.1 - 3.9e-50 170.2 0.0 4.7e-50 169.9 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Sgf11 PF08209.11 EXF83359.1 - 0.08 12.5 3.1 0.17 11.5 3.1 1.5 1 0 0 1 1 1 0 Sgf11 (transcriptional regulation protein) zf_UBZ PF18439.1 EXF83359.1 - 0.16 11.6 1.9 2 8.1 0.3 2.3 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger Apt1 PF10351.9 EXF83359.1 - 6.6 5.5 11.7 0.89 8.3 0.0 2.3 2 0 0 2 2 2 0 Golgi-body localisation protein domain Acetyltransf_1 PF00583.25 EXF83360.1 - 7.1e-06 26.3 0.0 9.7e-06 25.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EXF83360.1 - 0.0075 16.7 0.0 0.011 16.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain PRCC PF10253.9 EXF83360.1 - 8 7.2 13.8 0.34 11.7 8.0 1.7 2 0 0 2 2 2 0 Mitotic checkpoint regulator, MAD2B-interacting Hexokinase_1 PF00349.21 EXF83361.1 - 3.7e-76 255.5 0.0 7.8e-76 254.4 0.0 1.5 2 0 0 2 2 2 1 Hexokinase Hexokinase_2 PF03727.16 EXF83361.1 - 2.9e-75 252.8 0.0 4.1e-75 252.3 0.0 1.2 1 0 0 1 1 1 1 Hexokinase DUF4574 PF15141.6 EXF83361.1 - 0.017 15.0 0.1 0.035 14.0 0.1 1.4 1 0 0 1 1 1 0 Ubiquinol-cytochrome-c reductase complex assembly factor 3 MFS_5 PF05631.14 EXF83362.1 - 9e-70 235.3 9.7 1.3e-69 234.8 9.7 1.2 1 0 0 1 1 1 1 Sugar-tranasporters, 12 TM MFS_1 PF07690.16 EXF83362.1 - 1.8e-17 63.3 27.4 1.8e-17 63.3 27.4 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF83362.1 - 7.2e-05 21.8 22.5 0.004 16.1 10.5 2.6 2 1 0 2 2 2 2 Sugar (and other) transporter Colicin_V PF02674.16 EXF83362.1 - 0.18 11.8 11.2 5.3 7.0 5.9 2.8 2 0 0 2 2 2 0 Colicin V production protein Vpu PF00558.19 EXF83362.1 - 0.29 10.9 1.0 0.7 9.7 0.1 2.0 2 0 0 2 2 2 0 Vpu protein ATP-synt_G PF04718.15 EXF83364.1 - 1.3e-30 106.2 0.4 3.8e-30 104.7 0.1 1.8 2 0 0 2 2 2 1 Mitochondrial ATP synthase g subunit Senescence PF06911.12 EXF83364.1 - 0.026 14.8 6.8 0.054 13.8 6.8 1.6 1 1 0 1 1 1 0 Senescence-associated protein Rotamase_2 PF13145.6 EXF83364.1 - 0.029 15.2 1.5 0.13 13.1 0.1 2.1 2 0 0 2 2 2 0 PPIC-type PPIASE domain ADH_N PF08240.12 EXF83365.1 - 1.7e-27 95.4 2.3 3.7e-27 94.4 2.3 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EXF83365.1 - 5.9e-17 61.9 0.0 8.7e-17 61.3 0.0 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EXF83365.1 - 1.6e-05 24.5 0.5 0.00083 18.9 0.4 2.4 2 1 0 2 2 2 2 Glucose dehydrogenase C-terminus Isochorismatase PF00857.20 EXF83366.1 - 1.4e-26 93.7 0.0 3e-25 89.4 0.0 2.6 1 1 0 1 1 1 1 Isochorismatase family MDMPI_N PF11716.8 EXF83368.1 - 0.14 12.8 0.0 0.16 12.6 0.0 1.1 1 0 0 1 1 1 0 Mycothiol maleylpyruvate isomerase N-terminal domain Transp_cyt_pur PF02133.15 EXF83369.1 - 4.1e-42 144.5 37.5 5.1e-42 144.2 37.5 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin EZH2_N PF18601.1 EXF83370.1 - 2.9e-29 101.2 0.1 6.9e-29 100.0 0.1 1.7 1 0 0 1 1 1 1 EZH2 N-terminal domain Ezh2_MCSS PF18600.1 EXF83370.1 - 1.5e-22 78.9 2.9 2.9e-22 78.0 2.9 1.5 1 0 0 1 1 1 1 MCSS domain SET PF00856.28 EXF83370.1 - 6e-17 62.5 0.3 4.8e-16 59.6 0.3 2.6 1 1 0 1 1 1 1 SET domain preSET_CXC PF18264.1 EXF83370.1 - 6.8e-05 23.3 1.0 0.00021 21.7 1.0 1.8 1 0 0 1 1 1 1 CXC domain Pil1 PF13805.6 EXF83371.1 - 3.7e-125 416.7 0.2 4.7e-125 416.4 0.2 1.1 1 0 0 1 1 1 1 Eisosome component PIL1 FAM92 PF06730.11 EXF83371.1 - 0.092 12.2 2.7 0.33 10.4 2.7 1.9 1 1 0 1 1 1 0 FAM92 protein DUF1263 PF06882.12 EXF83371.1 - 0.12 12.5 0.0 0.48 10.5 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1263) CCDC84 PF14968.6 EXF83371.1 - 0.12 11.9 0.9 1.6 8.3 0.9 2.1 1 1 0 1 1 1 0 Coiled coil protein 84 Octopine_DH PF02317.17 EXF83371.1 - 0.13 12.3 0.5 0.54 10.3 0.5 1.9 1 1 0 1 1 1 0 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain LSM PF01423.22 EXF83372.1 - 2.1e-09 36.9 0.0 2.7e-09 36.6 0.0 1.2 1 0 0 1 1 1 1 LSM domain RcpC PF16976.5 EXF83372.1 - 0.033 14.2 0.0 0.065 13.3 0.0 1.5 1 1 1 2 2 2 0 Flp pilus assembly protein RcpC/CpaB SM-ATX PF14438.6 EXF83372.1 - 0.091 12.9 0.0 0.22 11.7 0.0 1.7 1 1 0 1 1 1 0 Ataxin 2 SM domain DUF3617 PF12276.8 EXF83372.1 - 0.1 12.9 0.0 0.18 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3617) XPG_N PF00752.17 EXF83373.1 - 1.9e-33 114.9 0.0 4.3e-33 113.8 0.0 1.7 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 EXF83373.1 - 3.8e-27 94.5 0.0 1.3e-26 92.8 0.0 2.0 1 0 0 1 1 1 1 XPG I-region UIM PF02809.20 EXF83373.1 - 0.0001 21.9 8.9 0.00052 19.8 1.1 4.3 2 0 0 2 2 2 1 Ubiquitin interaction motif 5_3_exonuc PF01367.20 EXF83373.1 - 0.038 14.6 0.0 0.13 12.8 0.0 1.9 1 0 0 1 1 1 0 5'-3' exonuclease, C-terminal SAM fold DUF1943 PF09172.11 EXF83373.1 - 0.25 10.6 4.3 0.065 12.5 0.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1943) DUF2229 PF09989.9 EXF83373.1 - 2.2 7.9 4.4 0.81 9.3 0.2 2.4 3 0 0 3 3 3 0 CoA enzyme activase uncharacterised domain (DUF2229) DUF2401 PF10287.9 EXF83374.1 - 6.5e-81 271.3 0.0 1.1e-80 270.5 0.0 1.4 1 0 0 1 1 1 1 Putative TOS1-like glycosyl hydrolase (DUF2401) DUF2403 PF10290.9 EXF83374.1 - 2.1e-22 79.3 0.0 5.7e-22 77.9 0.0 1.8 1 0 0 1 1 1 1 Glycine-rich protein domain (DUF2403) NmrA PF05368.13 EXF83375.1 - 7.8e-65 218.7 0.1 9.6e-65 218.4 0.1 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EXF83375.1 - 4.7e-21 75.5 0.1 7.3e-21 74.9 0.1 1.2 1 0 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 EXF83375.1 - 1.3e-06 27.7 0.1 1.9e-06 27.1 0.1 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EXF83375.1 - 0.00088 18.8 0.1 0.0015 18.1 0.1 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Sacchrp_dh_NADP PF03435.18 EXF83375.1 - 0.014 15.7 0.3 0.027 14.7 0.3 1.5 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Peroxin-13_N PF04088.13 EXF83376.1 - 1.6e-50 171.2 0.0 2.5e-50 170.5 0.0 1.3 1 0 0 1 1 1 1 Peroxin 13, N-terminal region SH3_2 PF07653.17 EXF83376.1 - 4.1e-08 32.8 0.0 8.1e-08 31.8 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EXF83376.1 - 2.9e-06 26.8 0.0 5.3e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EXF83376.1 - 6.9e-06 25.8 0.0 1.3e-05 25.0 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.11 EXF83376.1 - 0.029 14.7 0.1 0.07 13.4 0.0 1.7 2 0 0 2 2 2 0 Bacterial SH3 domain Keratin_2_head PF16208.5 EXF83376.1 - 2.6 8.1 30.5 5.3 7.2 30.5 1.6 1 0 0 1 1 1 0 Keratin type II head Bap31 PF05529.12 EXF83377.1 - 6.9e-49 165.2 9.6 9.5e-49 164.7 9.6 1.2 1 0 0 1 1 1 1 Bap31/Bap29 transmembrane region Bap31_Bap29_C PF18035.1 EXF83377.1 - 1.4e-14 53.8 7.2 2.3e-14 53.1 7.2 1.4 1 0 0 1 1 1 1 Bap31/Bap29 cytoplasmic coiled-coil domain TolA_bind_tri PF16331.5 EXF83377.1 - 0.0028 17.7 0.3 0.0062 16.6 0.3 1.5 1 0 0 1 1 1 1 TolA binding protein trimerisation DUF2956 PF11169.8 EXF83377.1 - 0.016 15.4 3.9 0.073 13.3 4.4 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2956) TMF_DNA_bd PF12329.8 EXF83377.1 - 0.035 14.1 4.4 0.063 13.3 4.4 1.4 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding Csm1_N PF18504.1 EXF83377.1 - 0.089 13.1 0.6 0.17 12.2 0.6 1.5 1 0 0 1 1 1 0 Csm1 N-terminal domain DUF192 PF02643.15 EXF83377.1 - 0.1 12.8 0.1 0.2 11.8 0.1 1.5 1 0 0 1 1 1 0 Uncharacterized ACR, COG1430 CAMSAP_CC1 PF17095.5 EXF83377.1 - 0.81 9.6 6.3 0.7 9.8 3.1 2.3 1 1 1 2 2 2 0 Spectrin-binding region of Ca2+-Calmodulin DivIC PF04977.15 EXF83377.1 - 0.87 9.4 5.1 0.93 9.3 0.8 2.6 3 0 0 3 3 3 0 Septum formation initiator CBP PF12192.8 EXF83378.1 - 1.4e-09 38.1 6.0 1.4e-09 38.1 6.0 1.9 1 1 1 2 2 2 1 Fungal calcium binding protein Dus PF01207.17 EXF83381.1 - 2.6e-37 128.6 0.0 6.4e-28 97.7 0.0 3.0 3 0 0 3 3 3 2 Dihydrouridine synthase (Dus) zf_CCCH_4 PF18345.1 EXF83381.1 - 0.01 15.9 8.6 0.99 9.6 1.1 3.4 3 0 0 3 3 3 0 Zinc finger domain zf-CCCH PF00642.24 EXF83381.1 - 5.1 7.1 10.3 1.3 9.1 0.1 2.8 3 0 0 3 3 3 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) DUF4554 PF15091.6 EXF83381.1 - 7.4 5.3 5.1 12 4.6 5.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4554) Metallophos PF00149.28 EXF83382.1 - 1e-33 117.6 0.0 1.5e-33 117.0 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EXF83382.1 - 5.1e-17 62.1 0.0 9.3e-17 61.2 0.0 1.5 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain SUR7 PF06687.12 EXF83383.1 - 1.2e-36 126.3 11.7 1.7e-36 125.9 11.7 1.2 1 0 0 1 1 1 1 SUR7/PalI family TMEM43 PF07787.12 EXF83383.1 - 0.033 13.6 0.4 0.061 12.7 0.4 1.4 1 0 0 1 1 1 0 Transmembrane protein 43 WD40 PF00400.32 EXF83384.1 - 1.4e-10 41.5 25.8 3.5e-05 24.5 0.1 11.0 14 0 0 14 14 14 2 WD domain, G-beta repeat 2OG-FeII_Oxy_2 PF13532.6 EXF83385.1 - 7.2e-21 75.3 0.0 2e-20 73.8 0.0 1.7 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily Toxin_2 PF00451.19 EXF83385.1 - 0.036 14.4 2.8 0.13 12.6 2.8 1.9 1 0 0 1 1 1 0 Scorpion short toxin, BmKK2 Auto_anti-p27 PF06677.12 EXF83385.1 - 2.8 8.2 0.0 2.8 8.2 0.0 4.1 5 0 0 5 5 5 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) AMP-binding PF00501.28 EXF83387.1 - 3.2e-73 246.7 0.0 4.1e-73 246.4 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EXF83387.1 - 5.1e-14 53.0 1.5 3e-13 50.5 1.9 2.1 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain EphA2_TM PF14575.6 EXF83389.1 - 0.0006 20.6 0.0 0.16 12.9 0.0 2.4 2 0 0 2 2 2 1 Ephrin type-A receptor 2 transmembrane domain TMEM154 PF15102.6 EXF83389.1 - 0.00065 19.6 0.0 0.031 14.2 0.0 2.3 2 0 0 2 2 2 1 TMEM154 protein family GT87 PF09594.10 EXF83389.1 - 0.0015 18.3 0.6 0.69 9.6 0.2 2.3 2 0 0 2 2 2 2 Glycosyltransferase family 87 DUF4381 PF14316.6 EXF83389.1 - 0.0015 18.7 1.3 0.29 11.3 0.1 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4381) MLANA PF14991.6 EXF83389.1 - 0.0037 17.5 0.0 3.8 7.8 0.0 2.4 2 0 0 2 2 2 1 Protein melan-A PTP_tm PF18861.1 EXF83389.1 - 0.0041 17.1 0.8 0.37 10.8 0.0 2.4 2 0 0 2 2 2 1 Transmembrane domain of protein tyrosine phosphatase, receptor type J BatD PF13584.6 EXF83389.1 - 0.0052 15.7 0.0 0.045 12.6 0.0 2.0 2 0 0 2 2 2 1 Oxygen tolerance Phage_holin_3_6 PF07332.11 EXF83389.1 - 0.0069 16.4 0.4 0.38 10.8 0.0 2.2 2 0 0 2 2 2 1 Putative Actinobacterial Holin-X, holin superfamily III DUF3180 PF11377.8 EXF83389.1 - 0.0074 16.4 0.3 0.4 10.8 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF3180) Syndecan PF01034.20 EXF83389.1 - 0.0089 15.9 0.0 3 7.8 0.0 2.6 2 0 0 2 2 2 1 Syndecan domain MHYT PF03707.16 EXF83389.1 - 0.012 15.8 2.6 4.1 7.6 0.1 2.6 2 1 0 2 2 2 0 Bacterial signalling protein N terminal repeat DUF202 PF02656.15 EXF83389.1 - 0.013 15.9 0.8 3 8.3 0.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF202) Chordopox_A13L PF05961.11 EXF83389.1 - 0.016 15.5 0.0 0.032 14.4 0.0 1.4 1 0 0 1 1 1 0 Chordopoxvirus A13L protein Phage_holin_2_4 PF16082.5 EXF83389.1 - 0.025 14.3 0.1 3.6 7.4 0.0 2.5 2 0 0 2 2 2 0 Bacteriophage holin family, superfamily II-like Gram_pos_anchor PF00746.21 EXF83389.1 - 0.031 14.2 2.9 2.3 8.3 0.2 2.4 2 0 0 2 2 2 0 LPXTG cell wall anchor motif RCR PF12273.8 EXF83389.1 - 0.034 14.8 0.0 0.92 10.2 0.0 2.4 2 0 0 2 2 2 0 Chitin synthesis regulation, resistance to Congo red LPG_synthase_TM PF03706.13 EXF83389.1 - 0.036 13.6 0.8 6.9 6.1 0.0 2.1 2 0 0 2 2 2 0 Lysylphosphatidylglycerol synthase TM region DUF4229 PF14012.6 EXF83389.1 - 0.041 14.0 1.0 0.11 12.6 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4229) DUF998 PF06197.13 EXF83389.1 - 0.05 13.2 2.4 0.74 9.4 0.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF998) TauE PF01925.19 EXF83389.1 - 0.054 13.1 6.3 1.5 8.4 1.6 2.1 2 0 0 2 2 2 0 Sulfite exporter TauE/SafE BatA PF07584.11 EXF83389.1 - 0.054 13.9 0.2 1.4 9.4 0.0 2.3 2 0 0 2 2 2 0 Aerotolerance regulator N-terminal RseC_MucC PF04246.12 EXF83389.1 - 0.061 13.3 0.0 5.4 7.0 0.0 2.2 2 0 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC Stevor PF17410.2 EXF83389.1 - 0.084 12.4 1.9 0.16 11.5 0.1 2.0 2 0 0 2 2 2 0 Subtelomeric Variable Open Reading frame NfeD PF01957.18 EXF83389.1 - 0.1 13.0 0.1 14 6.1 0.0 2.4 2 0 0 2 2 2 0 NfeD-like C-terminal, partner-binding Nitrate_red_gam PF02665.14 EXF83389.1 - 0.11 12.0 0.3 8.8 5.8 0.0 2.2 2 0 0 2 2 2 0 Nitrate reductase gamma subunit DUF4131 PF13567.6 EXF83389.1 - 0.12 12.0 1.3 12 5.5 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) Adeno_E3_CR2 PF02439.15 EXF83389.1 - 0.12 12.1 0.5 2.3 8.0 0.1 2.4 2 0 0 2 2 2 0 Adenovirus E3 region protein CR2 DUF5305 PF17231.2 EXF83389.1 - 0.15 11.4 0.0 2.8 7.3 0.0 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5305) CcmH PF03918.14 EXF83389.1 - 0.3 10.4 0.9 6.5 6.0 0.0 2.8 3 0 0 3 3 3 0 Cytochrome C biogenesis protein LapA_dom PF06305.11 EXF83389.1 - 0.43 10.4 1.3 9.3 6.1 0.1 2.2 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain MtrF PF09472.10 EXF83389.1 - 6.3 6.3 7.0 14 5.2 0.6 2.5 2 0 0 2 2 2 0 Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF) AAA_12 PF13087.6 EXF83390.1 - 2.1e-23 83.0 0.0 3.5e-23 82.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 EXF83390.1 - 2e-15 57.3 0.0 3.5e-15 56.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 EXF83390.1 - 0.00014 21.7 0.0 5.8 6.6 0.0 3.3 3 0 0 3 3 3 3 Viral (Superfamily 1) RNA helicase AAA_30 PF13604.6 EXF83390.1 - 0.0016 18.2 0.0 0.7 9.6 0.0 2.4 2 0 0 2 2 2 2 AAA domain UvrD_C_2 PF13538.6 EXF83390.1 - 0.0041 16.9 0.0 0.0098 15.7 0.0 1.6 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_22 PF13401.6 EXF83390.1 - 0.17 12.1 0.0 0.96 9.7 0.0 2.2 2 1 0 2 2 2 0 AAA domain zf-C2H2 PF00096.26 EXF83391.1 - 3.6e-06 27.1 23.7 0.036 14.5 0.9 3.6 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EXF83391.1 - 0.00066 20.3 20.0 0.43 11.6 2.9 3.7 3 0 0 3 3 3 3 C2H2-type zinc finger zf-MYST PF17772.1 EXF83391.1 - 0.074 12.7 0.1 0.17 11.6 0.1 1.5 1 0 0 1 1 1 0 MYST family zinc finger domain FANCL_C PF11793.8 EXF83391.1 - 0.28 11.4 2.7 0.56 10.4 2.7 1.4 1 0 0 1 1 1 0 FANCL C-terminal domain zf-C2H2_6 PF13912.6 EXF83391.1 - 0.31 11.1 7.6 1.9 8.6 1.6 3.5 3 0 0 3 3 3 0 C2H2-type zinc finger Syndecan PF01034.20 EXF83391.1 - 0.32 10.9 0.8 0.7 9.8 0.8 1.5 1 0 0 1 1 1 0 Syndecan domain Sina PF03145.16 EXF83391.1 - 4.2 7.3 12.3 34 4.3 10.1 2.2 1 1 1 2 2 2 0 Seven in absentia protein family Rrp40_N PF18311.1 EXF83392.1 - 4.1e-17 61.8 1.6 4.1e-17 61.8 1.6 1.9 2 0 0 2 2 2 1 Exosome complex exonuclease Rrp40 N-terminal domain KH_6 PF15985.5 EXF83392.1 - 1e-16 61.0 0.1 2.4e-16 59.8 0.0 1.7 2 0 0 2 2 2 1 KH domain HSP70 PF00012.20 EXF83393.1 - 1.6e-78 264.4 6.4 2.5e-78 263.8 6.4 1.3 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EXF83393.1 - 6.3e-11 41.7 0.3 1.1e-10 40.8 0.3 1.4 1 0 0 1 1 1 1 MreB/Mbl protein PilM_2 PF11104.8 EXF83393.1 - 0.0067 15.5 0.2 3 6.8 0.1 2.6 2 1 0 2 2 2 2 Type IV pilus assembly protein PilM; AAA_33 PF13671.6 EXF83393.1 - 0.14 12.3 0.0 0.26 11.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain NT-C2 PF10358.9 EXF83394.1 - 1.4e-21 76.7 0.4 1.2e-20 73.7 0.4 2.1 1 1 0 1 1 1 1 N-terminal C2 in EEIG1 and EHBP1 proteins Phostensin_N PF13916.6 EXF83394.1 - 0.16 12.3 2.2 0.4 11.1 2.2 1.6 1 0 0 1 1 1 0 PP1-regulatory protein, Phostensin N-terminal ERCC4 PF02732.15 EXF83396.1 - 1.6e-18 67.4 0.0 6.9e-18 65.3 0.0 2.0 2 0 0 2 2 2 1 ERCC4 domain WH1 PF00568.23 EXF83398.1 - 2.6e-25 88.5 0.1 3.8e-25 88.0 0.1 1.2 1 0 0 1 1 1 1 WH1 domain WH2 PF02205.20 EXF83398.1 - 0.002 17.9 0.5 0.002 17.9 0.5 1.9 2 0 0 2 2 2 1 WH2 motif eIF-1a PF01176.19 EXF83399.1 - 1.1e-21 76.3 0.1 1.6e-21 75.9 0.1 1.2 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 U1snRNP70_N PF12220.8 EXF83400.1 - 1.7 9.3 12.3 0.44 11.2 0.8 2.9 3 0 0 3 3 3 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal fn3_2 PF16893.5 EXF83401.1 - 2.2e-38 130.3 0.1 3.5e-38 129.6 0.1 1.3 1 0 0 1 1 1 1 Fibronectin type III domain CHS5_N PF16892.5 EXF83401.1 - 1.9e-23 82.1 0.8 3.3e-23 81.4 0.8 1.4 1 0 0 1 1 1 1 Chitin biosynthesis protein CHS5 N-terminus PTCB-BRCT PF12738.7 EXF83401.1 - 3.7e-12 46.0 0.0 6.9e-12 45.1 0.0 1.5 1 0 0 1 1 1 1 twin BRCT domain BRCT PF00533.26 EXF83401.1 - 1.2e-10 41.6 0.0 2.3e-10 40.7 0.0 1.5 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EXF83401.1 - 6.1e-06 26.6 0.0 2e-05 24.9 0.0 1.9 1 1 1 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain fn3 PF00041.21 EXF83401.1 - 0.00062 20.1 0.0 0.0018 18.6 0.0 1.7 1 0 0 1 1 1 1 Fibronectin type III domain DUF3006 PF11213.8 EXF83401.1 - 0.0067 16.6 0.4 0.024 14.8 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF3006) adh_short PF00106.25 EXF83402.1 - 1.1e-11 44.6 0.0 0.0026 17.2 0.0 3.1 2 1 1 3 3 3 3 short chain dehydrogenase adh_short_C2 PF13561.6 EXF83402.1 - 1.4e-09 37.9 0.0 7.2e-07 29.0 0.0 2.4 2 1 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF83402.1 - 0.00079 19.4 0.6 0.0023 17.9 0.6 1.7 1 1 0 1 1 1 1 KR domain Gcn1_N PF12074.8 EXF83402.1 - 0.03 13.6 2.6 0.047 13.0 2.6 1.3 1 0 0 1 1 1 0 Generalcontrol nonderepressible 1 (Gcn1) N-terminal NAD_binding_10 PF13460.6 EXF83402.1 - 0.032 14.1 0.8 6.3 6.6 0.3 2.3 1 1 1 2 2 2 0 NAD(P)H-binding TrkH PF02386.16 EXF83404.1 - 7.9e-91 305.0 11.6 4.3e-86 289.4 2.4 2.3 2 0 0 2 2 2 2 Cation transport protein Sugar_tr PF00083.24 EXF83405.1 - 1.4e-87 294.5 28.9 1.7e-87 294.2 28.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF83405.1 - 2.3e-23 82.7 47.1 3.6e-20 72.2 23.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 EXF83405.1 - 0.0023 16.3 2.2 0.0023 16.3 2.2 2.0 2 0 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family DUF697 PF05128.12 EXF83405.1 - 0.09 12.5 0.3 0.22 11.2 0.3 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF697) GFO_IDH_MocA PF01408.22 EXF83406.1 - 1.5e-22 80.6 0.1 2.7e-22 79.8 0.1 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 EXF83406.1 - 0.00054 20.0 0.1 0.002 18.1 0.0 1.9 2 0 0 2 2 2 1 Oxidoreductase family, C-terminal alpha/beta domain NAD_binding_2 PF03446.15 EXF83406.1 - 0.0038 17.4 0.0 0.023 14.9 0.0 2.0 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase Gp_dh_N PF00044.24 EXF83406.1 - 0.028 14.8 0.0 0.068 13.5 0.0 1.7 1 0 0 1 1 1 0 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain NAD_binding_7 PF13241.6 EXF83406.1 - 0.054 13.9 0.2 0.11 13.0 0.2 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding CoA_binding PF02629.19 EXF83406.1 - 0.13 12.9 0.3 0.32 11.7 0.1 1.8 2 0 0 2 2 2 0 CoA binding domain Fungal_trans PF04082.18 EXF83407.1 - 2.6e-09 36.5 0.0 4.8e-09 35.6 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain FMN_dh PF01070.18 EXF83408.1 - 1.8e-88 296.9 0.1 2.2e-47 161.8 0.0 2.1 1 1 1 2 2 2 2 FMN-dependent dehydrogenase Cyt-b5 PF00173.28 EXF83408.1 - 1.8e-20 72.9 0.0 3.5e-20 71.9 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Glu_synthase PF01645.17 EXF83408.1 - 1.4e-07 31.0 0.0 2.3e-07 30.3 0.0 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.25 EXF83408.1 - 8.7e-05 21.7 0.4 0.00019 20.5 0.3 1.5 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain NMO PF03060.15 EXF83408.1 - 0.0021 17.5 0.0 0.0029 17.0 0.0 1.2 1 0 0 1 1 1 1 Nitronate monooxygenase DUF5078 PF16877.5 EXF83408.1 - 0.0045 17.5 0.0 0.009 16.5 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF5078) MIOX PF05153.15 EXF83409.1 - 9.2e-121 402.1 1.0 9.2e-121 402.1 1.0 1.3 2 0 0 2 2 2 1 Myo-inositol oxygenase HD PF01966.22 EXF83409.1 - 0.061 13.6 0.3 1.1 9.4 0.0 2.6 2 1 1 3 3 3 0 HD domain Peroxidase_2 PF01328.17 EXF83411.1 - 5.8e-52 176.9 0.1 7.2e-52 176.6 0.1 1.0 1 0 0 1 1 1 1 Peroxidase, family 2 F-box PF00646.33 EXF83413.1 - 3.3e-07 30.0 0.2 1.1e-06 28.4 0.2 2.0 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EXF83413.1 - 0.0028 17.5 0.1 0.0074 16.2 0.1 1.7 1 0 0 1 1 1 1 F-box-like F-box_4 PF15966.5 EXF83413.1 - 0.0049 16.7 0.0 0.0093 15.8 0.0 1.4 1 0 0 1 1 1 1 F-box LRR_2 PF07723.13 EXF83413.1 - 0.11 13.2 0.2 52 4.7 0.0 4.5 5 0 0 5 5 5 0 Leucine Rich Repeat Sec10 PF07393.11 EXF83414.1 - 4.2e-220 732.9 10.4 4.2e-220 732.9 10.4 1.3 2 0 0 2 2 2 1 Exocyst complex component Sec10 Phage_Mu_Gam PF07352.12 EXF83414.1 - 0.48 10.3 2.8 0.58 10.0 0.1 2.6 3 0 0 3 3 3 0 Bacteriophage Mu Gam like protein DUF4407 PF14362.6 EXF83414.1 - 4.2 6.6 8.6 2.3 7.5 3.9 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) HIP1_clath_bdg PF16515.5 EXF83414.1 - 5.5 7.7 10.3 3.5 8.3 3.9 3.5 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF4225 PF13988.6 EXF83415.1 - 0.84 9.2 5.0 3.5 7.2 0.0 2.9 3 1 0 3 3 3 0 Protein of unknown function (DUF4225) Clr5 PF14420.6 EXF83416.1 - 2.1e-11 43.8 0.0 5e-11 42.7 0.0 1.6 1 0 0 1 1 1 1 Clr5 domain LID PF17916.1 EXF83416.1 - 0.03 14.0 0.1 0.059 13.0 0.1 1.4 1 0 0 1 1 1 0 LIM interaction domain (LID) Peptidase_M43 PF05572.13 EXF83417.1 - 2.6e-15 56.6 0.5 4.2e-15 56.0 0.5 1.4 1 0 0 1 1 1 1 Pregnancy-associated plasma protein-A Reprolysin_3 PF13582.6 EXF83417.1 - 2.7e-06 27.9 0.0 4.6e-06 27.2 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 EXF83417.1 - 4.2e-06 27.1 0.0 6.9e-06 26.3 0.0 1.3 1 1 0 1 1 1 1 Metallo-peptidase family M12 Peptidase_M10 PF00413.24 EXF83417.1 - 0.00033 20.5 0.0 0.00069 19.5 0.0 1.5 1 1 0 1 1 1 1 Matrixin Reprolysin_4 PF13583.6 EXF83417.1 - 0.018 14.7 1.2 0.032 13.9 1.2 1.5 1 1 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like DUF4953 PF16313.5 EXF83417.1 - 0.046 12.9 1.2 0.07 12.3 0.2 1.7 2 0 0 2 2 2 0 Met-zincin Reprolysin_2 PF13574.6 EXF83417.1 - 0.056 13.3 0.1 0.075 12.9 0.1 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_M66 PF10462.9 EXF83417.1 - 0.11 11.5 1.0 0.19 10.6 1.0 1.4 1 0 0 1 1 1 0 Peptidase M66 p450 PF00067.22 EXF83418.1 - 1.3e-52 179.1 0.0 1.8e-52 178.7 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 adh_short PF00106.25 EXF83420.1 - 7.6e-36 123.4 0.0 1.7e-35 122.2 0.0 1.5 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF83420.1 - 7.5e-26 91.1 0.0 1.2e-25 90.5 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF83420.1 - 1.6e-12 47.7 0.0 2.4e-12 47.1 0.0 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EXF83420.1 - 8.6e-07 28.7 0.0 1.1e-06 28.3 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EXF83420.1 - 1.5e-05 24.6 0.1 2.9e-05 23.6 0.1 1.4 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 EXF83420.1 - 5.9e-05 23.0 0.0 9.6e-05 22.4 0.0 1.3 1 1 0 1 1 1 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 EXF83420.1 - 0.00084 19.6 0.0 0.0016 18.7 0.0 1.5 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Polysacc_synt_2 PF02719.15 EXF83420.1 - 0.15 11.2 0.0 0.4 9.8 0.0 1.7 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein TraQ PF09679.10 EXF83421.1 - 0.071 13.0 0.1 0.19 11.7 0.1 1.7 1 0 0 1 1 1 0 Type-F conjugative transfer system pilin chaperone (TraQ) TPR_4 PF07721.14 EXF83421.1 - 0.17 12.6 1.4 0.61 10.9 1.4 2.0 1 0 0 1 1 1 0 Tetratricopeptide repeat WD40 PF00400.32 EXF83423.1 - 6.2e-40 134.5 23.0 1.4e-05 25.8 0.0 8.2 8 0 0 8 8 8 7 WD domain, G-beta repeat F-box PF00646.33 EXF83423.1 - 1.8e-10 40.5 1.0 4.2e-10 39.2 0.2 2.1 2 1 0 2 2 2 1 F-box domain F-box-like PF12937.7 EXF83423.1 - 2.5e-10 40.1 0.1 5e-10 39.1 0.1 1.6 1 0 0 1 1 1 1 F-box-like ANAPC4_WD40 PF12894.7 EXF83423.1 - 4.4e-08 33.3 1.2 2.1 8.7 0.0 5.7 2 2 4 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 EXF83423.1 - 0.0024 17.5 0.6 0.47 10.0 0.0 2.8 2 1 1 3 3 3 1 PQQ-like domain F-box_4 PF15966.5 EXF83423.1 - 0.01 15.7 0.0 0.029 14.3 0.0 1.7 1 0 0 1 1 1 0 F-box Nup160 PF11715.8 EXF83423.1 - 0.085 11.5 4.8 39 2.7 0.0 4.7 3 1 2 5 5 5 0 Nucleoporin Nup120/160 DUF4597 PF15366.6 EXF83423.1 - 0.82 9.5 7.2 0.71 9.7 0.1 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4597) SLATT_5 PF18160.1 EXF83424.1 - 0.019 14.3 0.3 0.049 13.0 0.3 1.6 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 5 P53_tetramer PF07710.11 EXF83424.1 - 0.056 12.8 0.0 0.17 11.3 0.0 1.8 1 0 0 1 1 1 0 P53 tetramerisation motif GMC_oxred_N PF00732.19 EXF83425.1 - 9.3e-54 182.8 0.0 1.9e-53 181.7 0.0 1.5 2 0 0 2 2 2 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EXF83425.1 - 4.1e-35 121.4 0.0 7.1e-35 120.6 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.24 EXF83425.1 - 0.0052 15.9 0.0 0.9 8.5 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.24 EXF83425.1 - 0.0069 16.0 0.1 0.09 12.3 0.0 2.5 3 0 0 3 3 3 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 EXF83425.1 - 0.031 13.3 0.0 0.045 12.8 0.0 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein NAD_binding_8 PF13450.6 EXF83425.1 - 0.12 12.6 0.1 0.31 11.3 0.1 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EXF83425.1 - 0.15 11.3 0.0 0.37 10.0 0.0 1.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase DLH PF01738.18 EXF83426.1 - 4.5e-25 88.5 0.2 5.9e-25 88.1 0.2 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family DUF747 PF05346.11 EXF83427.1 - 1.5e-120 402.5 5.8 1.9e-120 402.1 5.8 1.1 1 0 0 1 1 1 1 Eukaryotic membrane protein family DUF1761 PF08570.10 EXF83427.1 - 0.12 12.6 5.5 0.17 12.2 0.2 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1761) Apt1 PF10351.9 EXF83427.1 - 5.9 5.6 6.2 11 4.7 6.2 1.4 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF4834 PF16118.5 EXF83427.1 - 6.7 7.7 6.9 6 7.9 0.0 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) CDC45 PF02724.14 EXF83427.1 - 7.4 4.7 5.8 11 4.1 5.8 1.1 1 0 0 1 1 1 0 CDC45-like protein TMEM154 PF15102.6 EXF83427.1 - 8.6 6.3 7.3 4.1 7.3 0.1 2.5 2 0 0 2 2 2 0 TMEM154 protein family F-box PF00646.33 EXF83428.1 - 3.1e-08 33.3 0.3 3.1e-08 33.3 0.3 2.4 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 EXF83428.1 - 2.6e-07 30.4 1.4 7.1e-07 29.0 0.2 2.3 2 0 0 2 2 2 1 F-box-like RPEL PF02755.15 EXF83428.1 - 1.7e-05 24.4 0.1 0.0003 20.4 0.1 2.5 2 0 0 2 2 2 1 RPEL repeat F-box_4 PF15966.5 EXF83428.1 - 0.0016 18.3 1.6 0.0047 16.8 0.0 2.2 2 0 0 2 2 2 1 F-box PRANC PF09372.10 EXF83428.1 - 0.12 12.7 0.0 0.2 12.0 0.0 1.3 1 0 0 1 1 1 0 PRANC domain LAMTOR PF15454.6 EXF83429.1 - 7.2e-12 45.8 0.1 1.2e-11 45.1 0.1 1.3 1 0 0 1 1 1 1 Late endosomal/lysosomal adaptor and MAPK and MTOR activator AbiH PF14253.6 EXF83431.1 - 0.13 12.1 1.4 0.18 11.7 1.4 1.2 1 0 0 1 1 1 0 Bacteriophage abortive infection AbiH DUF1677 PF07911.13 EXF83431.1 - 0.24 11.8 0.1 0.24 11.8 0.1 2.2 2 2 0 2 2 2 0 Protein of unknown function (DUF1677) CNDH2_C PF16858.5 EXF83431.1 - 1.2 9.0 12.6 0.39 10.6 7.1 2.0 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term Med7 PF05983.11 EXF83432.1 - 3.3e-59 200.2 0.1 3.9e-59 200.0 0.1 1.1 1 0 0 1 1 1 1 MED7 protein TBCC_N PF16752.5 EXF83432.1 - 0.035 14.6 0.0 0.53 10.7 0.0 2.3 2 0 0 2 2 2 0 Tubulin-specific chaperone C N-terminal domain Ldh_1_C PF02866.18 EXF83433.1 - 0.15 12.0 0.0 0.17 11.8 0.0 1.1 1 0 0 1 1 1 0 lactate/malate dehydrogenase, alpha/beta C-terminal domain SPOC PF07744.13 EXF83434.1 - 2.1e-26 92.6 0.0 3.5e-26 91.9 0.0 1.4 1 0 0 1 1 1 1 SPOC domain TFIIS_M PF07500.14 EXF83434.1 - 3.8e-15 56.3 1.6 1e-14 54.9 1.6 1.8 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS), central domain PHD PF00628.29 EXF83434.1 - 4.7e-09 36.0 8.5 8.8e-09 35.1 8.5 1.5 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 EXF83434.1 - 0.66 9.6 3.2 1.1 8.8 3.2 1.4 1 0 0 1 1 1 0 PHD-finger CDC45 PF02724.14 EXF83434.1 - 0.9 7.8 9.4 1.6 6.9 9.4 1.4 1 0 0 1 1 1 0 CDC45-like protein Proteasome PF00227.26 EXF83435.1 - 1.3e-60 204.2 0.1 1.6e-60 203.8 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EXF83435.1 - 2.8e-13 49.3 0.1 8.7e-13 47.7 0.1 1.9 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature DUF5624 PF18538.1 EXF83435.1 - 0.011 15.9 0.7 0.035 14.2 0.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF5624) Nitrate_red_gam PF02665.14 EXF83435.1 - 0.022 14.3 0.0 0.032 13.8 0.0 1.2 1 0 0 1 1 1 0 Nitrate reductase gamma subunit DUF2838 PF10998.8 EXF83436.1 - 8.6e-45 151.5 9.1 8.6e-45 151.5 9.1 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF2838) FAM184 PF15665.5 EXF83436.1 - 0.065 13.0 2.3 0.13 12.0 2.3 1.4 1 0 0 1 1 1 0 Family with sequence similarity 184, A and B Prominin PF05478.11 EXF83436.1 - 0.1 10.6 0.0 0.15 10.0 0.0 1.1 1 0 0 1 1 1 0 Prominin DUF1640 PF07798.11 EXF83436.1 - 0.13 12.3 0.5 0.42 10.6 0.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1640) SMC_N PF02463.19 EXF83437.1 - 6.4e-59 199.1 4.4 4.1e-58 196.4 4.4 2.0 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EXF83437.1 - 7.4e-24 84.3 0.0 4.5e-23 81.8 0.0 2.4 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 EXF83437.1 - 4.8e-09 36.4 2.0 5.6e-05 23.1 0.1 4.6 3 3 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 EXF83437.1 - 3.9e-08 33.4 10.0 3.9e-08 33.4 10.0 4.5 2 2 2 4 4 2 1 AAA ATPase domain AAA_29 PF13555.6 EXF83437.1 - 1.1e-07 31.5 0.0 2.3e-07 30.4 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain FliJ PF02050.16 EXF83437.1 - 0.0089 16.2 10.6 0.0089 16.2 10.6 7.8 4 1 4 8 8 7 2 Flagellar FliJ protein SbcCD_C PF13558.6 EXF83437.1 - 0.012 15.8 0.0 0.085 13.1 0.0 2.6 2 0 0 2 2 1 0 Putative exonuclease SbcCD, C subunit Spc7 PF08317.11 EXF83437.1 - 0.035 13.0 120.5 0.22 10.4 10.1 7.2 3 2 4 7 7 7 0 Spc7 kinetochore protein PI-TkoII_IV PF18714.1 EXF83437.1 - 0.15 11.5 2.6 0.27 10.7 0.6 2.5 2 0 0 2 2 2 0 DNA polymerase II intein Domain IV DUF1730 PF08331.10 EXF83437.1 - 0.49 10.3 5.6 0.46 10.4 0.2 3.7 3 0 0 3 3 3 0 Domain of unknown function (DUF1730) DEAD PF00270.29 EXF83437.1 - 0.86 9.3 7.1 14 5.4 0.0 4.0 3 0 0 3 3 3 0 DEAD/DEAH box helicase DUF1664 PF07889.12 EXF83437.1 - 4.3 7.4 61.9 0.32 11.0 2.7 8.1 5 2 2 8 8 8 0 Protein of unknown function (DUF1664) DASH_Dam1 PF08653.10 EXF83437.1 - 9.8 6.1 8.0 33 4.4 0.1 4.8 4 1 1 5 5 5 0 DASH complex subunit Dam1 TFIIE_alpha PF02002.17 EXF83438.1 - 2.3e-14 53.1 0.1 5.3e-14 52.0 0.1 1.6 1 0 0 1 1 1 1 TFIIE alpha subunit zf-Dof PF02701.15 EXF83438.1 - 0.024 14.8 0.5 0.053 13.7 0.5 1.5 1 0 0 1 1 1 0 Dof domain, zinc finger zinc-ribbons_6 PF07191.12 EXF83438.1 - 0.068 13.2 0.1 0.15 12.1 0.1 1.5 1 0 0 1 1 1 0 zinc-ribbons Adhes-Ig_like PF09085.10 EXF83438.1 - 0.11 12.6 0.1 0.27 11.4 0.1 1.6 1 0 0 1 1 1 0 Adhesion molecule, immunoglobulin-like R3H-assoc PF13902.6 EXF83438.1 - 0.31 11.4 7.3 1.3 9.4 2.6 3.0 3 1 0 4 4 4 0 R3H-associated N-terminal domain zf-CCHC_2 PF13696.6 EXF83438.1 - 1.7 8.5 4.5 0.41 10.5 0.5 2.0 2 0 0 2 2 2 0 Zinc knuckle DNA_pol_lambd_f PF10391.9 EXF83439.1 - 2.6e-21 75.2 2.2 4.8e-21 74.3 0.7 2.2 2 0 0 2 2 2 1 Fingers domain of DNA polymerase lambda DNA_pol_B_palm PF14792.6 EXF83439.1 - 2.6e-20 72.8 0.0 4.9e-20 71.8 0.0 1.5 1 0 0 1 1 1 1 DNA polymerase beta palm DNA_pol_B_thumb PF14791.6 EXF83439.1 - 4.3e-19 68.5 0.0 1.2e-18 67.1 0.0 1.7 1 0 0 1 1 1 1 DNA polymerase beta thumb HHH_8 PF14716.6 EXF83439.1 - 2.3e-11 43.9 0.0 6.8e-11 42.4 0.0 1.9 1 0 0 1 1 1 1 Helix-hairpin-helix domain HHH_5 PF14520.6 EXF83439.1 - 1.8e-05 25.2 0.0 0.033 14.8 0.0 2.4 2 0 0 2 2 2 2 Helix-hairpin-helix domain NTP_transf_2 PF01909.23 EXF83439.1 - 0.014 15.6 0.0 0.064 13.5 0.0 2.1 2 0 0 2 2 2 0 Nucleotidyltransferase domain WSK PF03832.13 EXF83439.1 - 0.02 14.6 0.5 0.064 12.9 0.5 1.9 1 0 0 1 1 1 0 WSK motif MAPEG PF01124.18 EXF83440.1 - 1.1e-22 80.3 0.2 1.3e-22 80.1 0.2 1.1 1 0 0 1 1 1 1 MAPEG family Peptidase_M14 PF00246.24 EXF83441.1 - 2.6e-71 240.8 0.0 3.4e-71 240.4 0.0 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase Sec7 PF01369.20 EXF83442.1 - 6.4e-31 107.4 0.1 9.9e-31 106.8 0.1 1.2 1 0 0 1 1 1 1 Sec7 domain PH PF00169.29 EXF83442.1 - 5.4e-07 30.1 0.1 1.4e-06 28.8 0.1 1.7 1 0 0 1 1 1 1 PH domain PH_9 PF15410.6 EXF83442.1 - 2.4e-05 24.7 0.1 5.2e-05 23.6 0.1 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain SRP_TPR_like PF17004.5 EXF83443.1 - 3.2e-23 82.0 9.2 1.9e-22 79.5 2.2 2.8 2 1 1 3 3 3 1 Putative TPR-like repeat SRP72 PF08492.12 EXF83443.1 - 4.7e-15 55.8 7.8 4.7e-15 55.8 7.8 2.6 2 0 0 2 2 2 1 SRP72 RNA-binding domain TPR_14 PF13428.6 EXF83443.1 - 3.8e-07 30.4 14.9 4.1 8.5 0.0 8.6 8 1 1 9 9 9 2 Tetratricopeptide repeat TPR_2 PF07719.17 EXF83443.1 - 1.4e-06 28.0 13.9 0.025 14.7 0.1 6.4 7 0 0 7 7 5 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EXF83443.1 - 2.2e-05 24.6 8.1 0.00027 21.1 0.6 4.7 3 2 2 5 5 5 1 Anaphase-promoting complex, cyclosome, subunit 3 SPO22 PF08631.10 EXF83443.1 - 0.0001 21.9 5.6 0.019 14.5 0.4 3.2 2 1 0 3 3 3 1 Meiosis protein SPO22/ZIP4 like TPR_12 PF13424.6 EXF83443.1 - 0.00012 22.3 18.0 6.3 7.2 0.1 7.2 6 2 1 7 7 7 1 Tetratricopeptide repeat TPR_19 PF14559.6 EXF83443.1 - 0.00053 20.4 25.5 1.7 9.2 0.3 6.8 5 2 2 7 7 6 2 Tetratricopeptide repeat TPR_1 PF00515.28 EXF83443.1 - 0.0018 18.0 5.5 14 5.7 0.0 5.8 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_4 PF07721.14 EXF83443.1 - 0.0018 18.7 0.6 28 5.7 0.2 5.2 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_10 PF13374.6 EXF83443.1 - 0.0019 18.0 9.4 1.7 8.6 0.1 5.7 7 0 0 7 7 5 1 Tetratricopeptide repeat TPR_11 PF13414.6 EXF83443.1 - 0.0052 16.4 2.7 0.51 10.1 0.0 4.0 4 0 0 4 4 4 1 TPR repeat TPR_16 PF13432.6 EXF83443.1 - 0.13 13.0 0.3 0.13 13.0 0.3 6.0 8 0 0 8 8 6 0 Tetratricopeptide repeat TPR_MalT PF17874.1 EXF83443.1 - 0.16 11.3 9.0 0.99 8.7 1.0 3.8 3 2 0 3 3 3 0 MalT-like TPR region Fis1_TPR_C PF14853.6 EXF83443.1 - 0.3 11.2 2.4 1.5e+02 2.5 0.1 4.0 4 0 0 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat TPR_6 PF13174.6 EXF83443.1 - 0.6 10.9 7.2 1.1e+02 3.8 0.1 6.1 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_9 PF13371.6 EXF83443.1 - 2.6 8.3 12.3 38 4.5 1.0 5.6 7 0 0 7 7 7 0 Tetratricopeptide repeat SgrR_N PF12793.7 EXF83443.1 - 3.7 7.8 5.5 17 5.6 0.1 4.1 4 1 1 5 5 5 0 Sugar transport-related sRNA regulator N-term PMC2NT PF08066.12 EXF83444.1 - 0.072 13.8 3.3 1.8 9.3 0.0 3.3 2 1 1 3 3 3 0 PMC2NT (NUC016) domain ALMT PF11744.8 EXF83444.1 - 1.5 7.6 6.6 2 7.1 6.6 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Glyco_trans_2_3 PF13632.6 EXF83445.1 - 0.085 12.8 0.8 0.17 11.8 0.0 1.8 2 0 0 2 2 2 0 Glycosyl transferase family group 2 Aminotran_1_2 PF00155.21 EXF83446.1 - 8.6e-66 222.6 0.0 1.3e-65 222.0 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 EXF83446.1 - 0.00035 19.9 0.0 0.0006 19.2 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.20 EXF83446.1 - 0.0013 17.3 0.0 0.005 15.4 0.0 1.8 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 EXF83446.1 - 0.0059 15.9 0.0 0.043 13.1 0.0 2.1 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 EXF83446.1 - 0.0088 15.0 0.1 0.033 13.2 0.0 1.9 3 0 0 3 3 3 1 Aminotransferase class-V Foie-gras_1 PF11817.8 EXF83446.1 - 0.078 12.6 0.1 0.21 11.1 0.0 1.6 2 0 0 2 2 2 0 Foie gras liver health family 1 PP1_bind PF15276.6 EXF83448.1 - 0.015 15.6 2.3 0.015 15.6 2.3 3.4 2 2 1 3 3 3 0 Protein phosphatase 1 binding DUF2981 PF11200.8 EXF83448.1 - 0.99 9.1 11.9 1.2 8.8 11.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) Pneumo_att_G PF05539.11 EXF83448.1 - 3.6 7.1 16.9 4.7 6.7 16.9 1.1 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G SWI-SNF_Ssr4 PF08549.10 EXF83448.1 - 7.7 5.0 18.2 8.8 4.8 18.2 1.1 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) MFS_1 PF07690.16 EXF83449.1 - 5.2e-23 81.5 42.6 3.4e-22 78.9 41.4 2.0 1 1 0 1 1 1 1 Major Facilitator Superfamily FAD_binding_3 PF01494.19 EXF83450.1 - 4.8e-63 213.5 0.0 7.3e-63 212.9 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EXF83450.1 - 5.9e-05 22.4 0.1 0.0057 15.9 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EXF83450.1 - 0.0002 20.7 1.9 0.016 14.4 0.5 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EXF83450.1 - 0.00073 19.7 0.1 0.0019 18.4 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EXF83450.1 - 0.0012 18.5 4.0 0.019 14.5 0.2 3.3 3 1 0 3 3 3 1 FAD dependent oxidoreductase Thi4 PF01946.17 EXF83450.1 - 0.002 17.4 0.0 0.0037 16.5 0.0 1.3 1 0 0 1 1 1 1 Thi4 family HI0933_like PF03486.14 EXF83450.1 - 0.0023 16.7 0.3 0.0038 16.0 0.0 1.5 2 0 0 2 2 2 1 HI0933-like protein Lycopene_cycl PF05834.12 EXF83450.1 - 0.003 16.7 0.5 0.31 10.0 0.2 2.2 2 0 0 2 2 2 2 Lycopene cyclase protein Pyr_redox PF00070.27 EXF83450.1 - 0.0097 16.4 0.3 0.15 12.6 0.1 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DIT1_PvcA PF05141.12 EXF83451.1 - 1.1e-95 320.3 0.0 1.6e-95 319.7 0.0 1.3 1 0 0 1 1 1 1 Pyoverdine/dityrosine biosynthesis protein TauD PF02668.16 EXF83451.1 - 1.1e-24 87.6 0.0 2.9e-24 86.3 0.0 1.7 1 1 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family p450 PF00067.22 EXF83452.1 - 2.1e-33 115.8 0.0 3.5e-31 108.5 0.0 2.0 2 0 0 2 2 2 2 Cytochrome P450 AA_permease_2 PF13520.6 EXF83453.1 - 1e-37 130.0 54.9 1.3e-37 129.7 54.9 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EXF83453.1 - 1.1e-16 60.5 43.7 1.6e-16 60.0 43.7 1.2 1 0 0 1 1 1 1 Amino acid permease VIT1 PF01988.19 EXF83453.1 - 0.009 15.9 0.2 0.009 15.9 0.2 3.1 2 1 1 3 3 3 1 VIT family FAD_binding_3 PF01494.19 EXF83454.1 - 4e-15 55.9 2.8 1.9e-13 50.4 2.8 2.7 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.24 EXF83454.1 - 9.4e-07 28.7 0.1 0.00013 21.7 0.1 2.5 1 1 1 3 3 3 1 FAD dependent oxidoreductase SE PF08491.10 EXF83454.1 - 1.2e-05 24.6 0.0 0.00064 18.9 0.0 2.1 2 0 0 2 2 2 1 Squalene epoxidase NAD_binding_9 PF13454.6 EXF83454.1 - 3.2e-05 24.0 0.3 0.00028 20.9 0.3 2.3 1 1 0 1 1 1 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 EXF83454.1 - 9.4e-05 21.8 0.1 0.0043 16.3 0.0 2.1 1 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EXF83454.1 - 0.0009 19.4 0.0 0.0025 18.0 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EXF83454.1 - 0.0086 15.2 0.1 0.018 14.1 0.1 1.5 1 0 0 1 1 1 1 FAD binding domain GIDA PF01134.22 EXF83454.1 - 0.03 13.4 0.0 0.054 12.6 0.0 1.4 1 0 0 1 1 1 0 Glucose inhibited division protein A HI0933_like PF03486.14 EXF83454.1 - 0.073 11.8 0.0 0.12 11.1 0.0 1.3 1 0 0 1 1 1 0 HI0933-like protein Abhydrolase_6 PF12697.7 EXF83455.1 - 5.2e-19 69.7 0.0 6e-19 69.5 0.0 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EXF83455.1 - 0.00019 20.8 0.0 0.00045 19.6 0.0 1.6 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 EXF83455.1 - 0.0049 17.0 0.0 0.014 15.5 0.0 1.7 2 0 0 2 2 2 1 Thioesterase domain zinc_ribbon_5 PF13719.6 EXF83455.1 - 0.096 12.5 0.1 16 5.4 0.2 2.4 2 0 0 2 2 2 0 zinc-ribbon domain Abhydrolase_8 PF06259.12 EXF83455.1 - 0.15 11.6 0.0 0.28 10.8 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase Fungal_trans PF04082.18 EXF83456.1 - 2.8e-08 33.1 0.1 4.9e-08 32.3 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF83456.1 - 5.5e-07 29.6 10.5 9.6e-07 28.8 10.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CoA_transf_3 PF02515.17 EXF83457.1 - 3.9e-43 148.0 0.0 3.4e-40 138.3 0.0 2.2 2 0 0 2 2 2 2 CoA-transferase family III ISET-FN3_linker PF16625.5 EXF83457.1 - 0.086 13.4 0.4 0.29 11.7 0.5 1.8 2 0 0 2 2 2 0 Unstructured linking region I-set and fnIII on Brother of CDO Dioxygenase_C PF00775.21 EXF83458.1 - 5.4e-48 162.8 0.0 7.2e-48 162.4 0.0 1.2 1 0 0 1 1 1 1 Dioxygenase Dioxygenase_N PF04444.14 EXF83458.1 - 2.1e-29 101.2 0.1 3.2e-29 100.6 0.1 1.3 1 0 0 1 1 1 1 Catechol dioxygenase N terminus CarboxypepD_reg PF13620.6 EXF83458.1 - 0.00011 22.4 0.0 0.00092 19.4 0.0 2.3 2 0 0 2 2 2 1 Carboxypeptidase regulatory-like domain DUF4198 PF10670.9 EXF83458.1 - 0.042 14.2 0.0 0.071 13.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4198) RHH_8 PF17723.1 EXF83458.1 - 0.17 12.0 0.0 0.33 11.1 0.0 1.4 1 0 0 1 1 1 0 Ribbon-Helix-Helix transcriptional regulator family OPT PF03169.15 EXF83459.1 - 3.1e-166 554.6 55.7 3.5e-166 554.4 55.7 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein DUF5592 PF17332.2 EXF83459.1 - 0.51 10.9 4.6 0.48 11.0 1.6 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5592) DUF2427 PF10348.9 EXF83459.1 - 1.1 9.1 9.9 0.089 12.6 1.4 3.5 4 0 0 4 4 4 0 Domain of unknown function (DUF2427) HsbA PF12296.8 EXF83460.1 - 2.4e-15 57.0 3.1 3.4e-15 56.5 3.1 1.2 1 0 0 1 1 1 1 Hydrophobic surface binding protein A mTERF PF02536.14 EXF83460.1 - 0.039 12.9 0.2 0.047 12.6 0.2 1.0 1 0 0 1 1 1 0 mTERF KIP1 PF07765.12 EXF83460.1 - 0.053 13.6 0.1 0.2 11.8 0.0 1.9 2 0 0 2 2 2 0 KIP1-like protein DUF1936 PF09151.10 EXF83461.1 - 0.25 11.3 0.9 2.2 8.3 0.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1936) LysM PF01476.20 EXF83464.1 - 2e-10 40.5 0.5 5e-10 39.3 0.2 1.8 2 0 0 2 2 2 1 LysM domain Na_H_Exchanger PF00999.21 EXF83465.1 - 8.1e-29 100.6 33.9 1e-23 83.8 22.3 3.1 3 0 0 3 3 3 3 Sodium/hydrogen exchanger family Trypan_PARP PF05887.11 EXF83465.1 - 0.00084 19.3 0.0 0.008 16.2 0.0 2.2 2 0 0 2 2 2 1 Procyclic acidic repetitive protein (PARP) Pex14_N PF04695.13 EXF83465.1 - 0.51 11.0 8.7 2.7 8.6 4.0 2.5 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Fst_toxin PF13955.6 EXF83465.1 - 0.82 9.7 0.1 0.82 9.7 0.1 2.9 3 0 0 3 3 3 0 Toxin Fst, type I toxin-antitoxin system REPA_OB_2 PF16900.5 EXF83466.1 - 0.067 13.1 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 Replication protein A OB domain MFS_1 PF07690.16 EXF83467.1 - 1.1e-49 169.3 36.4 1.1e-49 169.3 36.4 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF83467.1 - 1.6e-10 40.5 26.3 4.6e-10 39.0 26.4 1.7 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_4 PF06779.14 EXF83467.1 - 2e-06 27.4 9.4 2e-06 27.4 9.4 1.9 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB MFS_3 PF05977.13 EXF83467.1 - 0.019 13.4 7.0 0.026 12.9 7.0 1.2 1 0 0 1 1 1 0 Transmembrane secretion effector DUF2127 PF09900.9 EXF83467.1 - 5.5 7.2 9.4 0.46 10.7 1.7 2.8 2 1 0 2 2 2 0 Predicted membrane protein (DUF2127) Zip PF02535.22 EXF83469.1 - 0.0054 16.0 0.0 0.0065 15.7 0.0 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter DAO PF01266.24 EXF83470.1 - 5.9e-34 118.2 0.0 6.9e-34 118.0 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EXF83470.1 - 4.8e-06 26.7 0.0 1.4e-05 25.2 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Glu_dehyd_C PF16912.5 EXF83470.1 - 0.0041 16.6 0.0 0.0084 15.6 0.0 1.4 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus Trp_halogenase PF04820.14 EXF83470.1 - 0.0077 15.1 0.0 0.79 8.5 0.0 2.1 2 0 0 2 2 2 2 Tryptophan halogenase Thi4 PF01946.17 EXF83470.1 - 0.064 12.5 0.0 0.1 11.8 0.0 1.2 1 0 0 1 1 1 0 Thi4 family Pyr_redox_2 PF07992.14 EXF83470.1 - 0.091 12.0 0.0 0.99 8.6 0.0 2.2 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.16 EXF83470.1 - 0.11 12.1 0.0 0.24 11.1 0.0 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Shikimate_DH PF01488.20 EXF83470.1 - 0.14 12.2 0.0 0.25 11.4 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase OPT PF03169.15 EXF83471.1 - 4.3e-170 567.4 49.1 5e-170 567.2 49.1 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Fungal_trans_2 PF11951.8 EXF83472.1 - 5.1e-69 232.9 2.5 6.3e-69 232.6 2.5 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF83472.1 - 1.6e-08 34.5 6.7 1.6e-08 34.5 6.7 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF4791 PF16039.5 EXF83472.1 - 0.16 11.5 0.1 0.39 10.2 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4791) DUF2407_C PF13373.6 EXF83473.1 - 6.4e-35 120.4 0.0 9e-35 119.9 0.0 1.2 1 0 0 1 1 1 1 DUF2407 C-terminal domain DUF2407 PF10302.9 EXF83473.1 - 9.3e-29 100.1 0.0 1.4e-28 99.5 0.0 1.3 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain ubiquitin PF00240.23 EXF83473.1 - 0.0015 18.3 0.0 0.0038 16.9 0.0 1.6 2 0 0 2 2 2 1 Ubiquitin family Rad60-SLD_2 PF13881.6 EXF83473.1 - 0.049 13.7 0.0 0.13 12.4 0.0 1.7 2 0 0 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like rRNA_proc-arch PF13234.6 EXF83474.1 - 1.2e-85 287.8 0.0 3.5e-85 286.2 0.0 1.9 1 0 0 1 1 1 1 rRNA-processing arch domain DSHCT PF08148.12 EXF83474.1 - 1.1e-48 165.1 2.3 1.9e-48 164.2 1.1 2.1 2 0 0 2 2 2 1 DSHCT (NUC185) domain DEAD PF00270.29 EXF83474.1 - 2.4e-19 69.8 0.0 1.6e-18 67.1 0.0 2.4 3 0 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EXF83474.1 - 3.7e-08 33.7 0.1 1.7e-07 31.6 0.1 2.1 1 1 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EXF83474.1 - 2.8e-05 24.2 0.0 7.1e-05 22.9 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit T2SSE PF00437.20 EXF83474.1 - 0.028 13.5 0.0 0.063 12.3 0.0 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_22 PF13401.6 EXF83474.1 - 0.045 14.0 0.0 0.23 11.8 0.0 2.2 2 0 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 EXF83474.1 - 0.13 12.2 0.9 0.48 10.3 0.0 2.4 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea Herpes_LMP2 PF07415.11 EXF83474.1 - 0.53 9.0 2.4 0.8 8.4 2.4 1.1 1 0 0 1 1 1 0 Gammaherpesvirus latent membrane protein (LMP2) protein COX7C PF02935.16 EXF83475.1 - 1.9e-23 82.5 4.9 2.3e-23 82.2 4.9 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIIc PPR_2 PF13041.6 EXF83476.1 - 2.5e-21 75.6 2.4 2.1e-06 27.8 0.1 5.4 4 1 1 5 5 5 5 PPR repeat family PPR PF01535.20 EXF83476.1 - 6.4e-12 44.9 9.1 1.2e-05 25.2 0.1 5.5 6 0 0 6 6 6 2 PPR repeat PPR_3 PF13812.6 EXF83476.1 - 7e-09 35.6 0.0 0.0017 18.4 0.0 4.1 4 0 0 4 4 4 2 Pentatricopeptide repeat domain PPR_1 PF12854.7 EXF83476.1 - 3.1e-08 33.2 6.0 0.0049 16.5 0.0 4.3 4 1 0 4 4 4 3 PPR repeat PPR_long PF17177.4 EXF83476.1 - 0.002 17.5 0.2 0.047 13.1 0.1 2.9 2 1 0 3 3 3 1 Pentacotripeptide-repeat region of PRORP MRP-S25 PF13741.6 EXF83477.1 - 8.5e-63 212.0 10.4 2.1e-59 200.9 10.4 2.2 1 1 0 1 1 1 1 Mitochondrial ribosomal protein S25 MRP-S23 PF10484.9 EXF83477.1 - 1.4 9.2 5.3 1 9.7 2.9 1.9 1 1 0 2 2 2 0 Mitochondrial ribosomal protein S23 Alg14 PF08660.11 EXF83478.1 - 9.2e-45 152.7 0.0 1.5e-44 152.0 0.0 1.3 1 0 0 1 1 1 1 Oligosaccharide biosynthesis protein Alg14 like CytB6-F_Fe-S PF08802.10 EXF83478.1 - 0.27 11.3 1.4 9.7 6.3 0.0 2.8 2 0 0 2 2 2 0 Cytochrome B6-F complex Fe-S subunit Ima1_N PF09779.9 EXF83479.1 - 1.8e-24 87.2 0.1 3.6e-24 86.2 0.1 1.5 1 0 0 1 1 1 1 Ima1 N-terminal domain Y_phosphatase2 PF03162.13 EXF83480.1 - 2e-45 154.4 0.0 3.4e-45 153.6 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.6 EXF83480.1 - 3.3e-10 40.3 0.0 8.3e-10 39.0 0.0 1.6 1 1 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 EXF83480.1 - 0.0055 16.3 0.0 0.008 15.8 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 EXF83480.1 - 0.012 15.5 0.0 0.019 14.8 0.0 1.5 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Aim19 PF10315.9 EXF83481.1 - 0.0062 16.8 0.8 0.034 14.5 0.1 2.0 1 1 1 2 2 2 1 Altered inheritance of mitochondria protein 19 Fumerase PF05681.14 EXF83481.1 - 0.13 11.7 0.0 0.18 11.2 0.0 1.1 1 0 0 1 1 1 0 Fumarate hydratase (Fumerase) DUF1977 PF09320.11 EXF83482.1 - 2.7e-30 104.7 0.0 6.6e-30 103.5 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1977) DnaJ PF00226.31 EXF83482.1 - 1e-19 70.4 0.1 1.8e-19 69.6 0.1 1.4 1 0 0 1 1 1 1 DnaJ domain Steroid_dh PF02544.16 EXF83483.1 - 1e-16 61.3 1.8 1.7e-14 54.1 1.8 2.2 1 1 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.12 EXF83483.1 - 0.00025 20.6 0.2 0.00046 19.8 0.2 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) KilA-N PF04383.13 EXF83484.1 - 0.00082 19.2 0.0 0.011 15.6 0.0 2.2 1 1 0 1 1 1 1 KilA-N domain SVIP PF15811.5 EXF83484.1 - 0.39 11.2 2.2 1.4 9.4 0.7 2.3 2 0 0 2 2 2 0 Small VCP/p97-interacting protein Med1 PF10744.9 EXF83485.1 - 3.2e-127 425.0 0.0 4e-127 424.7 0.0 1.1 1 0 0 1 1 1 1 Mediator of RNA polymerase II transcription subunit 1 GATase_6 PF13522.6 EXF83486.1 - 5.9e-14 52.4 0.0 1.3e-13 51.3 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 EXF83486.1 - 4.5e-13 49.2 0.0 1.2e-12 47.8 0.0 1.7 2 0 0 2 2 2 1 Glutamine amidotransferase domain Pribosyltran PF00156.27 EXF83486.1 - 6.4e-09 35.5 0.1 1.3e-08 34.5 0.1 1.4 1 0 0 1 1 1 1 Phosphoribosyl transferase domain GATase_4 PF13230.6 EXF83486.1 - 0.00016 20.7 0.0 0.00029 19.8 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferases class-II Stc1 PF12898.7 EXF83487.1 - 5.6e-21 74.9 2.4 1.1e-20 73.9 2.4 1.5 1 0 0 1 1 1 1 Stc1 domain RAP1 PF07218.11 EXF83487.1 - 0.074 11.3 1.9 0.1 10.9 1.9 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) BCDHK_Adom3 PF10436.9 EXF83488.1 - 2.4e-76 255.1 0.0 3.4e-76 254.6 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 EXF83488.1 - 6.6e-13 49.2 0.0 1.2e-12 48.3 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 EXF83488.1 - 0.069 13.0 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Tropomyosin_1 PF12718.7 EXF83489.1 - 0.014 15.6 3.5 0.014 15.6 3.5 1.6 2 0 0 2 2 2 0 Tropomyosin like Lectin_N PF03954.14 EXF83489.1 - 0.17 11.6 1.1 0.32 10.7 1.1 1.4 1 0 0 1 1 1 0 Hepatic lectin, N-terminal domain NBP1 PF08537.10 EXF83489.1 - 0.35 10.2 4.1 0.14 11.6 1.1 1.7 2 0 0 2 2 2 0 Fungal Nap binding protein NBP1 PilJ PF13675.6 EXF83489.1 - 1.5 8.8 5.0 0.65 10.0 0.6 2.4 3 0 0 3 3 3 0 Type IV pili methyl-accepting chemotaxis transducer N-term Alpha-amylase PF00128.24 EXF83490.1 - 5.1e-48 164.4 0.0 1.2e-47 163.1 0.0 1.6 1 1 0 1 1 1 1 Alpha amylase, catalytic domain DUF1966 PF09260.11 EXF83490.1 - 9e-13 48.3 0.0 2e-12 47.2 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1966) SH3_2 PF07653.17 EXF83490.1 - 0.04 13.6 0.0 0.075 12.7 0.0 1.4 1 0 0 1 1 1 0 Variant SH3 domain Sugar_tr PF00083.24 EXF83491.1 - 9.6e-95 318.1 22.7 1.3e-94 317.7 22.7 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF83491.1 - 1.7e-20 73.3 19.2 1.7e-20 73.3 19.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF726 PF05277.12 EXF83493.1 - 9.4e-132 439.1 5.0 1.2e-131 438.7 5.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF726) DUF2951 PF11166.8 EXF83493.1 - 1.1 9.5 3.1 1e+02 3.2 4.5 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2951) Glu-tRNAGln PF02686.15 EXF83494.1 - 1.1e-11 44.8 0.0 4e-11 43.0 0.0 1.8 1 1 0 1 1 1 1 Glu-tRNAGln amidotransferase C subunit SNAP PF14938.6 EXF83495.1 - 9.3e-115 382.9 14.7 1.1e-114 382.7 14.7 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.6 EXF83495.1 - 4.4e-09 36.5 7.8 0.00039 20.6 0.1 3.6 2 2 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 EXF83495.1 - 7.9e-07 28.7 9.8 0.9 9.8 0.1 5.9 5 1 0 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 EXF83495.1 - 2.8e-06 27.1 8.4 0.25 11.7 0.1 5.4 5 1 0 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.6 EXF83495.1 - 0.0053 16.7 7.3 2.8 8.2 0.3 5.1 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_6 PF13174.6 EXF83495.1 - 0.018 15.7 12.2 42 5.1 0.1 5.7 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_1 PF00515.28 EXF83495.1 - 0.018 14.9 13.1 0.5 10.3 0.1 5.2 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_19 PF14559.6 EXF83495.1 - 0.078 13.5 0.1 0.078 13.5 0.1 4.0 3 2 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 EXF83495.1 - 0.089 13.5 17.6 0.93 10.2 0.0 4.8 3 2 2 5 5 5 0 Tetratricopeptide repeat TPR_9 PF13371.6 EXF83495.1 - 0.098 12.8 4.8 2.3 8.4 0.4 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 EXF83495.1 - 0.11 13.4 14.0 50 5.1 0.3 5.5 3 2 2 5 5 5 0 Tetratricopeptide repeat TPR_3 PF07720.12 EXF83495.1 - 0.73 9.9 6.7 2.5 8.2 0.5 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat DENN PF02141.21 EXF83496.1 - 1.3e-58 198.0 0.1 2.2e-58 197.3 0.1 1.3 1 0 0 1 1 1 1 DENN (AEX-3) domain dDENN PF03455.19 EXF83496.1 - 8.7e-16 57.7 1.3 2e-15 56.5 1.3 1.7 1 0 0 1 1 1 1 dDENN domain uDENN PF03456.18 EXF83496.1 - 2.1e-13 50.8 0.0 4.6e-13 49.7 0.0 1.6 1 0 0 1 1 1 1 uDENN domain C1_2 PF03107.16 EXF83496.1 - 0.0018 18.5 7.9 0.0035 17.6 7.9 1.4 1 0 0 1 1 1 1 C1 domain C1_1 PF00130.22 EXF83496.1 - 0.014 15.2 8.9 0.032 14.1 8.9 1.6 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Zf_RING PF16744.5 EXF83496.1 - 0.21 11.7 2.5 0.48 10.6 2.5 1.5 1 0 0 1 1 1 0 KIAA1045 RING finger PHD PF00628.29 EXF83496.1 - 0.37 10.7 6.8 0.86 9.5 6.8 1.7 1 0 0 1 1 1 0 PHD-finger zf-HIT PF04438.16 EXF83496.1 - 5.5 7.0 5.0 11 6.0 5.0 1.4 1 0 0 1 1 1 0 HIT zinc finger DUF974 PF06159.13 EXF83497.1 - 9.3e-80 268.0 0.0 1.1e-79 267.7 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF974) KH_1 PF00013.29 EXF83498.1 - 1.1e-08 34.8 0.0 1.7e-06 27.7 0.0 2.5 2 0 0 2 2 2 2 KH domain ALS_ss_C PF10369.9 EXF83499.1 - 1.7e-15 57.0 0.0 2.3e-14 53.3 0.0 2.5 2 1 0 2 2 2 1 Small subunit of acetolactate synthase ACT PF01842.25 EXF83499.1 - 7.1e-15 54.5 0.1 1.3e-14 53.6 0.1 1.5 1 0 0 1 1 1 1 ACT domain ACT_5 PF13710.6 EXF83499.1 - 1.3e-08 34.5 0.1 2.9e-08 33.4 0.0 1.6 2 0 0 2 2 2 1 ACT domain ACT_6 PF13740.6 EXF83499.1 - 0.11 12.5 0.0 26 4.9 0.0 2.6 2 0 0 2 2 2 0 ACT domain OTCace_N PF02729.21 EXF83500.1 - 4.9e-44 149.9 0.1 6.9e-44 149.4 0.1 1.2 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain OTCace PF00185.24 EXF83500.1 - 4.4e-43 147.1 0.0 8.9e-43 146.1 0.0 1.5 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain DUF3712 PF12505.8 EXF83501.1 - 2.2e-08 34.4 0.1 3.9e-06 27.1 0.1 3.0 3 0 0 3 3 3 2 Protein of unknown function (DUF3712) PEHE PF15275.6 EXF83503.1 - 1.5 9.4 7.5 0.6 10.8 2.0 2.2 1 1 0 2 2 2 0 PEHE domain SART-1 PF03343.13 EXF83504.1 - 1.9e-185 618.1 68.3 2.2e-185 617.9 68.3 1.0 1 0 0 1 1 1 1 SART-1 family Glyco_hydro_15 PF00723.21 EXF83505.1 - 2.1e-104 349.8 0.0 2.5e-104 349.6 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 CBM_20 PF00686.19 EXF83505.1 - 6.7e-35 118.9 0.4 1.4e-34 117.9 0.4 1.6 1 0 0 1 1 1 1 Starch binding domain CPT PF07931.12 EXF83506.1 - 5.2e-05 23.1 0.0 8.4e-05 22.5 0.0 1.5 1 0 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein AAA_18 PF13238.6 EXF83506.1 - 0.0015 19.1 0.0 0.0034 17.9 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.6 EXF83506.1 - 0.039 14.2 0.0 0.063 13.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain PRK PF00485.18 EXF83506.1 - 0.04 13.7 0.0 0.1 12.4 0.0 1.7 2 1 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family CoaE PF01121.20 EXF83506.1 - 0.1 12.2 0.0 0.21 11.3 0.0 1.5 1 0 0 1 1 1 0 Dephospho-CoA kinase PTH2 PF01981.16 EXF83507.1 - 8.2e-45 151.9 0.2 1.1e-44 151.4 0.2 1.2 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 BING4CT PF08149.11 EXF83508.1 - 1.6e-36 123.9 0.0 2.5e-33 113.7 0.0 3.5 3 0 0 3 3 3 1 BING4CT (NUC141) domain ANAPC4_WD40 PF12894.7 EXF83508.1 - 2.2e-05 24.6 0.1 3.7 7.9 0.0 5.6 3 1 4 7 7 7 2 Anaphase-promoting complex subunit 4 WD40 domain Coatomer_WDAD PF04053.14 EXF83508.1 - 2.7e-05 23.4 0.1 6.7e-05 22.1 0.0 1.6 2 0 0 2 2 2 1 Coatomer WD associated region WD40 PF00400.32 EXF83508.1 - 2.8e-05 24.8 0.1 0.038 14.9 0.0 4.1 5 0 0 5 5 5 1 WD domain, G-beta repeat MFS_1 PF07690.16 EXF83509.1 - 1e-17 64.1 35.4 1e-17 64.1 35.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF83509.1 - 1.1e-06 27.9 5.8 1.1e-06 27.9 5.8 3.1 1 1 0 2 2 2 1 Sugar (and other) transporter DUF4131 PF13567.6 EXF83509.1 - 0.093 12.4 0.2 0.093 12.4 0.2 4.1 3 3 3 6 6 6 0 Domain of unknown function (DUF4131) SOG2 PF10428.9 EXF83510.1 - 1.2 8.2 23.0 1.5 7.9 23.0 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein CAP59_mtransfer PF11735.8 EXF83511.1 - 4.7e-64 216.4 0.0 5.9e-64 216.0 0.0 1.1 1 0 0 1 1 1 1 Cryptococcal mannosyltransferase 1 ABC_tran PF00005.27 EXF83512.1 - 3.8e-46 157.0 0.4 2.2e-22 80.0 0.0 3.6 2 1 0 2 2 2 2 ABC transporter SET PF00856.28 EXF83512.1 - 1.3e-11 45.2 0.1 1.9e-09 38.1 0.0 3.5 3 2 0 3 3 3 1 SET domain AAA_21 PF13304.6 EXF83512.1 - 2.5e-11 44.0 3.3 0.00069 19.5 0.0 4.4 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EXF83512.1 - 1.5e-08 34.4 0.7 0.063 12.7 0.1 4.4 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EXF83512.1 - 2.2e-08 33.7 0.2 0.00059 19.5 0.0 3.2 3 0 0 3 3 3 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 EXF83512.1 - 1.3e-06 28.5 0.3 0.08 13.0 0.0 3.1 3 0 0 3 3 2 2 50S ribosome-binding GTPase ABC_tran_Xtn PF12848.7 EXF83512.1 - 4.5e-06 26.6 1.4 4.5e-06 26.6 1.4 2.1 2 0 0 2 2 1 1 ABC transporter AAA_22 PF13401.6 EXF83512.1 - 1.6e-05 25.2 0.2 0.059 13.6 0.0 3.0 2 1 0 2 2 2 2 AAA domain AAA_28 PF13521.6 EXF83512.1 - 3e-05 24.3 1.7 0.0064 16.8 0.0 3.2 3 0 0 3 3 3 1 AAA domain NACHT PF05729.12 EXF83512.1 - 9.2e-05 22.4 0.0 0.044 13.7 0.0 3.0 3 0 0 3 3 2 1 NACHT domain AAA_33 PF13671.6 EXF83512.1 - 9.3e-05 22.6 0.2 0.67 10.1 0.0 3.3 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 EXF83512.1 - 0.00019 22.0 0.1 1.1 9.8 0.1 3.0 3 0 0 3 3 2 2 AAA domain RsgA_GTPase PF03193.16 EXF83512.1 - 0.00024 21.1 2.7 0.48 10.3 0.0 2.9 3 0 0 3 3 2 2 RsgA GTPase AAA_30 PF13604.6 EXF83512.1 - 0.00029 20.6 0.7 1.3 8.7 0.1 3.3 3 0 0 3 3 3 2 AAA domain MeaB PF03308.16 EXF83512.1 - 0.00053 19.0 0.8 0.22 10.5 0.1 2.5 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_23 PF13476.6 EXF83512.1 - 0.0016 19.0 15.9 0.021 15.3 4.2 3.7 3 1 0 3 3 3 2 AAA domain AAA_16 PF13191.6 EXF83512.1 - 0.0016 18.8 3.1 0.42 11.0 1.0 2.9 2 1 0 2 2 2 1 AAA ATPase domain DUF87 PF01935.17 EXF83512.1 - 0.0017 18.5 9.8 0.077 13.1 0.1 3.0 4 0 0 4 4 2 2 Helicase HerA, central domain AAA_27 PF13514.6 EXF83512.1 - 0.0018 17.9 0.0 0.062 12.9 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_15 PF13175.6 EXF83512.1 - 0.0035 17.1 10.4 0.081 12.6 0.0 3.7 3 1 0 4 4 4 2 AAA ATPase domain Dynamin_N PF00350.23 EXF83512.1 - 0.0041 17.2 1.5 2.1 8.4 0.0 3.0 2 1 0 2 2 2 1 Dynamin family AAA PF00004.29 EXF83512.1 - 0.0058 17.1 0.0 0.9 10.0 0.0 2.8 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.12 EXF83512.1 - 0.0089 15.3 0.2 2.7 7.2 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin Thymidylate_kin PF02223.17 EXF83512.1 - 0.013 15.2 0.1 1.7 8.3 0.0 2.6 2 0 0 2 2 2 0 Thymidylate kinase AAA_14 PF13173.6 EXF83512.1 - 0.014 15.4 0.0 7.6 6.6 0.0 3.4 4 0 0 4 4 3 0 AAA domain NTPase_1 PF03266.15 EXF83512.1 - 0.016 15.1 0.1 5 7.0 0.0 3.0 3 0 0 3 3 3 0 NTPase Arf PF00025.21 EXF83512.1 - 0.021 14.3 0.6 0.2 11.1 0.2 2.2 2 0 0 2 2 2 0 ADP-ribosylation factor family RNA_helicase PF00910.22 EXF83512.1 - 0.026 14.9 0.1 4 7.9 0.0 2.5 2 0 0 2 2 2 0 RNA helicase DUF815 PF05673.13 EXF83512.1 - 0.026 13.7 0.1 5.3 6.1 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF815) TsaE PF02367.17 EXF83512.1 - 0.028 14.4 0.3 2.8 7.9 0.0 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_24 PF13479.6 EXF83512.1 - 0.049 13.3 0.1 8.2 6.1 0.0 2.7 2 0 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 EXF83512.1 - 0.063 13.2 0.0 0.88 9.4 0.0 2.3 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea ATP-synt_ab PF00006.25 EXF83512.1 - 0.076 12.6 0.1 13 5.4 0.0 2.4 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain Roc PF08477.13 EXF83512.1 - 0.078 13.2 0.6 15 5.8 0.0 2.7 3 0 0 3 3 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_5 PF07728.14 EXF83512.1 - 0.088 12.8 0.4 2.3 8.2 0.0 3.0 3 1 0 3 3 2 0 AAA domain (dynein-related subfamily) Viral_helicase1 PF01443.18 EXF83512.1 - 0.13 12.0 0.0 18 5.0 0.0 3.0 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase MobB PF03205.14 EXF83512.1 - 0.14 12.0 0.2 23 4.9 0.0 2.5 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_7 PF12775.7 EXF83512.1 - 0.14 11.6 0.1 2.1 7.8 0.0 2.2 2 0 0 2 2 2 0 P-loop containing dynein motor region cobW PF02492.19 EXF83512.1 - 0.23 11.0 1.7 10 5.7 0.0 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain NB-ARC PF00931.22 EXF83512.1 - 0.37 9.9 6.9 1.6 7.8 0.0 3.5 3 1 0 3 3 3 0 NB-ARC domain AAA_17 PF13207.6 EXF83512.1 - 0.46 10.9 10.2 9 6.7 0.0 4.2 4 0 0 4 4 4 0 AAA domain Gti1_Pac2 PF09729.9 EXF83513.1 - 4.5e-61 206.1 0.0 6.9e-61 205.5 0.0 1.3 1 0 0 1 1 1 1 Gti1/Pac2 family CDP-OH_P_transf PF01066.21 EXF83514.1 - 1.9e-15 57.4 0.3 1.9e-15 57.4 0.3 2.5 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase GIDA PF01134.22 EXF83515.1 - 2.2e-158 527.5 0.0 2.8e-158 527.1 0.0 1.1 1 0 0 1 1 1 1 Glucose inhibited division protein A GIDA_assoc PF13932.6 EXF83515.1 - 3.7e-67 226.6 0.0 6.1e-67 225.9 0.0 1.3 1 0 0 1 1 1 1 GidA associated domain FAD_oxidored PF12831.7 EXF83515.1 - 1.7e-05 24.4 0.4 2.9e-05 23.6 0.4 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EXF83515.1 - 3.5e-05 23.2 0.6 0.00029 20.2 0.8 2.0 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EXF83515.1 - 0.0048 16.0 2.2 0.0048 16.0 2.2 2.0 3 0 0 3 3 3 1 FAD binding domain AlaDh_PNT_C PF01262.21 EXF83515.1 - 0.0084 15.4 0.5 0.0084 15.4 0.5 2.0 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain HI0933_like PF03486.14 EXF83515.1 - 0.94 8.1 5.5 1.8 7.2 0.7 2.5 3 0 0 3 3 3 0 HI0933-like protein Sec1 PF00995.23 EXF83516.1 - 3.9e-135 452.3 0.0 4.7e-135 452.1 0.0 1.1 1 0 0 1 1 1 1 Sec1 family MMM1 PF10296.9 EXF83517.1 - 1.3e-137 458.4 0.1 4.3e-136 453.3 0.1 2.0 1 1 0 1 1 1 1 Maintenance of mitochondrial morphology protein 1 DUF3981 PF13139.6 EXF83517.1 - 0.19 12.1 0.0 0.35 11.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3981) CPBP PF02517.16 EXF83518.1 - 8.5e-14 51.7 10.4 8.5e-14 51.7 10.4 2.5 2 1 0 2 2 2 1 CPBP intramembrane metalloprotease Ribosomal_60s PF00428.19 EXF83519.1 - 0.012 16.1 3.2 0.02 15.5 3.2 1.2 1 0 0 1 1 1 0 60s Acidic ribosomal protein MBOAT PF03062.19 EXF83521.1 - 4.5e-58 197.3 5.0 9.3e-58 196.2 5.0 1.5 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family EamA PF00892.20 EXF83522.1 - 0.00017 21.8 6.5 0.00017 21.8 6.5 2.2 2 0 0 2 2 2 2 EamA-like transporter family UPF0370 PF13980.6 EXF83522.1 - 0.11 12.6 0.0 0.39 10.8 0.0 2.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0370) TPT PF03151.16 EXF83522.1 - 0.33 10.3 19.2 1.2 8.4 19.2 1.8 1 1 0 1 1 1 0 Triose-phosphate Transporter family PHO4 PF01384.20 EXF83522.1 - 2.4 7.1 17.3 0.084 11.9 6.7 2.5 1 1 1 2 2 2 0 Phosphate transporter family adh_short PF00106.25 EXF83523.1 - 1.2e-29 103.1 0.0 1.7e-29 102.7 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF83523.1 - 2.7e-20 73.0 0.0 3.8e-20 72.5 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF83523.1 - 2e-09 37.6 0.0 2.9e-09 37.1 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EXF83523.1 - 9.8e-08 31.7 0.0 1.9e-07 30.8 0.0 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EXF83523.1 - 0.00014 20.9 0.0 0.00021 20.4 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 EXF83523.1 - 0.00051 19.3 0.0 0.00071 18.8 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 EXF83523.1 - 0.00081 18.6 0.0 0.0019 17.4 0.0 1.6 2 0 0 2 2 2 1 RmlD substrate binding domain NAD_binding_10 PF13460.6 EXF83523.1 - 0.006 16.5 0.0 0.01 15.7 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 EXF83523.1 - 0.0078 15.6 0.0 0.012 15.1 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase DapB_N PF01113.20 EXF83523.1 - 0.14 12.3 0.0 0.22 11.7 0.0 1.4 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus ARD PF03079.14 EXF83524.1 - 1.5e-44 152.0 0.4 1.8e-44 151.7 0.4 1.1 1 0 0 1 1 1 1 ARD/ARD' family Cupin_2 PF07883.11 EXF83524.1 - 1.1e-08 34.7 0.1 2e-08 33.8 0.1 1.4 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.19 EXF83524.1 - 1.8e-05 24.7 0.0 2.6e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 AraC-like ligand binding domain DER1 PF04511.15 EXF83525.1 - 6e-52 176.4 5.1 6.9e-52 176.2 5.1 1.0 1 0 0 1 1 1 1 Der1-like family Histone PF00125.24 EXF83526.1 - 5.3e-42 143.3 0.9 5.9e-42 143.1 0.9 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 EXF83526.1 - 2.7e-06 27.4 0.0 4e-06 26.9 0.0 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 EXF83526.1 - 0.00011 22.5 0.1 0.00016 22.0 0.1 1.2 1 0 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 EXF83526.1 - 0.0065 16.7 0.1 0.0095 16.2 0.1 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 EXF83526.1 - 0.082 13.0 0.0 0.11 12.6 0.0 1.2 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit DUF1576 PF07613.11 EXF83527.1 - 0.011 15.2 0.2 0.02 14.4 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1576) Creatinase_N_2 PF16189.5 EXF83528.1 - 2.6e-54 183.7 0.4 1.5e-52 178.0 0.0 2.6 3 0 0 3 3 3 1 Creatinase/Prolidase N-terminal domain Peptidase_M24 PF00557.24 EXF83528.1 - 1.9e-43 148.6 0.1 2.5e-43 148.2 0.1 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 Creatinase_N PF01321.18 EXF83528.1 - 6e-22 78.7 0.0 2.2e-17 64.0 0.0 2.4 2 0 0 2 2 2 2 Creatinase/Prolidase N-terminal domain Peptidase_M24_C PF16188.5 EXF83528.1 - 1.5e-20 73.0 0.3 4.6e-20 71.4 0.3 1.9 1 0 0 1 1 1 1 C-terminal region of peptidase_M24 Importin_rep_3 PF18806.1 EXF83529.1 - 0.0024 17.9 0.0 0.013 15.5 0.0 2.2 2 0 0 2 2 2 1 Importin 13 repeat tRNA-synt_1b PF00579.25 EXF83530.1 - 1.5e-73 247.7 0.0 1.8e-73 247.5 0.0 1.0 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) tRNA-synt_1f PF01921.18 EXF83530.1 - 0.15 10.9 0.0 0.27 10.1 0.0 1.3 1 0 0 1 1 1 0 tRNA synthetases class I (K) Ribosomal_L32p PF01783.23 EXF83530.1 - 1.9 8.8 4.4 34 4.8 0.5 2.6 2 0 0 2 2 2 0 Ribosomal L32p protein family Ribosomal_S10 PF00338.22 EXF83531.1 - 1.1e-24 86.5 0.0 1.9e-24 85.7 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e Fcf2 PF08698.11 EXF83532.1 - 2.6e-34 117.5 0.6 1.2e-32 112.2 0.0 2.3 1 1 1 2 2 2 2 Fcf2 pre-rRNA processing CBFD_NFYB_HMF PF00808.23 EXF83533.1 - 2.4e-19 69.4 0.5 3.7e-19 68.8 0.5 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EXF83533.1 - 3.5e-15 56.5 0.1 7.2e-15 55.5 0.1 1.5 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Pol_alpha_B_N PF08418.10 EXF83533.1 - 0.017 15.1 0.1 0.02 14.9 0.1 1.2 1 0 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal CENP-X PF09415.10 EXF83533.1 - 0.045 14.1 0.0 0.072 13.4 0.0 1.3 1 0 0 1 1 1 0 CENP-S associating Centromere protein X Sec15 PF04091.12 EXF83534.1 - 1.3e-106 356.6 3.9 1.3e-106 356.6 3.9 2.1 2 0 0 2 2 2 1 Exocyst complex subunit Sec15-like DUF4201 PF13870.6 EXF83534.1 - 0.00055 19.7 4.5 0.00055 19.7 4.5 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4201) DUF3510 PF12022.8 EXF83534.1 - 0.034 14.5 1.6 2.2 8.7 0.1 3.3 2 1 1 3 3 3 0 Domain of unknown function (DUF3510) COG5 PF10392.9 EXF83534.1 - 0.065 13.4 4.0 0.44 10.7 2.5 2.7 2 0 0 2 2 2 0 Golgi transport complex subunit 5 SIMPL PF04402.14 EXF83534.1 - 0.071 13.6 2.0 1.8 9.0 1.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF541) BORCS8 PF10167.9 EXF83534.1 - 0.093 12.7 3.4 0.48 10.4 0.9 2.8 2 0 0 2 2 2 0 BLOC-1-related complex sub-unit 8 COG2 PF06148.11 EXF83534.1 - 9.2 6.4 13.9 0.095 12.8 2.2 3.3 4 0 0 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 RRM_2 PF04059.12 EXF83535.1 - 2e-38 130.5 0.4 3.3e-38 129.8 0.4 1.3 1 0 0 1 1 1 1 RNA recognition motif 2 RRM_1 PF00076.22 EXF83535.1 - 0.00015 21.5 0.1 0.26 11.1 0.0 2.6 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EXF83535.1 - 0.084 12.7 0.0 6.5 6.7 0.0 2.4 2 0 0 2 2 2 0 Occluded RNA-recognition motif Sad1_UNC PF07738.13 EXF83536.1 - 4e-33 114.2 0.0 1.1e-32 112.8 0.0 1.8 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal Fungal_TACC PF12709.7 EXF83536.1 - 0.094 13.2 0.1 0.24 11.9 0.1 1.6 1 0 0 1 1 1 0 Fungal Transforming acidic coiled-coil (TACC) proteins Cutinase PF01083.22 EXF83539.1 - 3.7e-33 115.0 0.0 5.8e-33 114.3 0.0 1.3 1 0 0 1 1 1 1 Cutinase Jacalin PF01419.17 EXF83539.1 - 5.5e-06 26.3 0.5 0.00012 22.0 0.2 2.1 1 1 1 2 2 2 1 Jacalin-like lectin domain DUF3089 PF11288.8 EXF83539.1 - 0.008 15.7 0.0 0.014 14.9 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3089) VirJ PF06057.11 EXF83539.1 - 0.024 14.5 0.0 0.18 11.7 0.0 2.0 2 0 0 2 2 2 0 Bacterial virulence protein (VirJ) PE-PPE PF08237.11 EXF83539.1 - 0.029 13.9 0.0 0.051 13.1 0.0 1.3 1 0 0 1 1 1 0 PE-PPE domain DUF2974 PF11187.8 EXF83539.1 - 0.11 12.0 0.0 0.35 10.4 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2974) Lipase_3 PF01764.25 EXF83539.1 - 0.15 11.9 0.0 0.25 11.2 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) UPF0114 PF03350.16 EXF83540.1 - 0.039 14.2 0.1 0.062 13.5 0.1 1.3 1 0 0 1 1 1 0 Uncharacterized protein family, UPF0114 ABC2_membrane PF01061.24 EXF83540.1 - 0.76 9.1 2.9 4.1 6.7 0.3 2.2 2 0 0 2 2 2 0 ABC-2 type transporter ABC_membrane PF00664.23 EXF83541.1 - 7.8e-26 91.3 13.0 1.2e-25 90.8 13.0 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 EXF83541.1 - 3.2e-16 60.1 0.2 1.4e-15 58.0 0.0 2.1 2 0 0 2 2 2 1 ABC transporter SMC_N PF02463.19 EXF83541.1 - 3.9e-05 23.2 0.0 0.00023 20.7 0.0 2.0 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EXF83541.1 - 0.00015 21.7 4.9 0.0062 16.4 0.6 2.6 2 1 1 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system T2SSE PF00437.20 EXF83541.1 - 0.00062 18.9 0.0 0.0016 17.6 0.0 1.6 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_22 PF13401.6 EXF83541.1 - 0.0015 18.8 0.1 0.0067 16.7 0.1 2.0 1 1 0 1 1 1 1 AAA domain FtsK_SpoIIIE PF01580.18 EXF83541.1 - 0.0018 17.7 0.0 0.0039 16.6 0.0 1.5 1 0 0 1 1 1 1 FtsK/SpoIIIE family AAA_16 PF13191.6 EXF83541.1 - 0.0035 17.7 0.1 0.011 16.2 0.1 1.7 1 1 0 1 1 1 1 AAA ATPase domain SbcCD_C PF13558.6 EXF83541.1 - 0.0038 17.4 0.7 0.057 13.7 0.0 2.6 2 0 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_29 PF13555.6 EXF83541.1 - 0.0087 15.8 0.1 0.022 14.5 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain Zeta_toxin PF06414.12 EXF83541.1 - 0.03 13.6 0.1 0.55 9.5 0.0 2.5 2 0 0 2 2 2 0 Zeta toxin AAA_24 PF13479.6 EXF83541.1 - 0.042 13.6 0.0 0.08 12.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 EXF83541.1 - 0.044 13.7 0.1 0.24 11.3 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase P_gingi_FimA PF06321.11 EXF83541.1 - 0.061 13.4 0.0 3.9 7.6 0.0 2.4 2 0 0 2 2 2 0 Major fimbrial subunit protein (FimA) AAA_7 PF12775.7 EXF83541.1 - 0.1 12.1 0.0 0.16 11.4 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region ABC_tran PF00005.27 EXF83542.1 - 1.1e-12 48.6 0.0 2.7e-12 47.4 0.0 1.7 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 EXF83542.1 - 3.6e-09 36.7 8.2 8.1e-09 35.5 8.2 1.6 1 0 0 1 1 1 1 ABC transporter transmembrane region AAA_16 PF13191.6 EXF83542.1 - 0.00045 20.7 0.3 0.0012 19.3 0.1 1.8 2 0 0 2 2 1 1 AAA ATPase domain T2SSE PF00437.20 EXF83542.1 - 0.0022 17.1 0.0 0.0038 16.3 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_7 PF12775.7 EXF83542.1 - 0.0041 16.6 0.2 0.0071 15.9 0.2 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA PF00004.29 EXF83542.1 - 0.0046 17.4 0.1 0.01 16.2 0.1 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 EXF83542.1 - 0.0063 16.4 0.1 0.012 15.5 0.1 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_22 PF13401.6 EXF83542.1 - 0.007 16.6 1.4 0.016 15.5 0.2 2.1 3 0 0 3 3 3 1 AAA domain AAA_25 PF13481.6 EXF83542.1 - 0.0072 15.9 0.1 0.014 15.0 0.1 1.4 1 0 0 1 1 1 1 AAA domain PduV-EutP PF10662.9 EXF83542.1 - 0.01 15.6 0.1 0.034 13.9 0.1 1.9 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_33 PF13671.6 EXF83542.1 - 0.013 15.6 0.0 0.036 14.2 0.0 1.7 2 0 0 2 2 2 0 AAA domain DUF3464 PF11947.8 EXF83542.1 - 0.022 14.5 0.3 0.059 13.1 0.1 1.8 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 TsaE PF02367.17 EXF83542.1 - 0.023 14.7 0.1 0.044 13.8 0.1 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Rad17 PF03215.15 EXF83542.1 - 0.045 13.7 0.2 0.12 12.2 0.2 1.7 1 0 0 1 1 1 0 Rad17 P-loop domain DUF2474 PF10617.9 EXF83542.1 - 0.062 13.2 0.2 0.19 11.6 0.2 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2474) AAA_11 PF13086.6 EXF83542.1 - 0.12 12.1 0.1 0.22 11.3 0.1 1.3 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EXF83542.1 - 0.13 12.6 0.0 0.34 11.3 0.0 1.7 1 0 0 1 1 1 0 RNA helicase Cyclin_N PF00134.23 EXF83543.1 - 1.7e-11 43.9 0.1 4.5e-11 42.6 0.1 1.7 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C_2 PF16899.5 EXF83543.1 - 0.0033 17.8 0.6 0.012 16.0 0.3 2.1 2 1 0 2 2 2 1 Cyclin C-terminal domain Las1 PF04031.13 EXF83543.1 - 0.023 14.8 0.7 1.8 8.7 0.7 2.8 1 1 0 1 1 1 0 Las1-like Turandot PF07240.11 EXF83543.1 - 0.12 12.3 0.1 0.25 11.3 0.1 1.5 1 0 0 1 1 1 0 Stress-inducible humoral factor Turandot TFIIB PF00382.19 EXF83543.1 - 0.14 12.3 0.1 0.14 12.3 0.1 1.8 2 0 0 2 2 2 0 Transcription factor TFIIB repeat Mito_carr PF00153.27 EXF83544.1 - 4.4e-67 222.1 6.4 5.4e-24 83.9 0.1 3.6 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_7 PF13499.6 EXF83544.1 - 5.1e-19 68.5 4.4 7.7e-12 45.5 1.0 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 EXF83544.1 - 6.7e-16 56.6 5.7 8.8e-05 21.8 0.8 4.4 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 EXF83544.1 - 1e-13 50.0 6.8 0.00012 21.7 0.1 4.4 4 0 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.6 EXF83544.1 - 1.9e-13 49.2 6.2 1.8e-05 24.0 0.7 3.4 3 0 0 3 3 3 2 EF hand SPARC_Ca_bdg PF10591.9 EXF83544.1 - 1.3e-07 31.9 0.2 6.7e-05 23.2 0.0 2.4 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_8 PF13833.6 EXF83544.1 - 5.4e-06 26.2 6.2 0.0015 18.4 0.5 3.1 2 1 1 3 3 3 3 EF-hand domain pair Serine_protease PF18405.1 EXF83544.1 - 0.027 13.6 2.0 1.2 8.3 0.0 3.0 3 0 0 3 3 3 0 Gammaproteobacterial serine protease EspB_PE PF18625.1 EXF83544.1 - 0.42 11.1 5.2 5.3 7.6 2.7 2.5 1 1 1 2 2 2 0 ESX-1 secreted protein B PE domain Med13_C PF06333.12 EXF83544.1 - 4.1 6.6 10.2 2.3 7.4 8.3 1.5 1 1 0 1 1 1 0 Mediator complex subunit 13 C-terminal domain DUF4097 PF13349.6 EXF83545.1 - 5.2e-06 26.0 0.1 0.0011 18.4 0.0 3.5 2 1 0 2 2 2 2 Putative adhesin ATP_bind_3 PF01171.20 EXF83546.1 - 8.4e-40 136.5 0.0 7.6e-27 94.2 0.0 2.3 2 0 0 2 2 2 2 PP-loop family Mito_carr PF00153.27 EXF83547.1 - 1.9e-45 152.7 7.1 1.5e-19 69.7 0.1 4.3 3 1 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 EXF83547.1 - 0.0064 15.7 1.0 0.11 11.6 0.2 2.3 2 0 0 2 2 2 1 Gammaproteobacterial serine protease K-cyclin_vir_C PF09080.10 EXF83547.1 - 0.012 16.1 0.2 0.032 14.7 0.2 1.7 1 0 0 1 1 1 0 K cyclin, C terminal DUF3337 PF11816.8 EXF83548.1 - 3e-55 186.7 0.0 6.4e-55 185.6 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3337) WD40 PF00400.32 EXF83548.1 - 2.6e-16 59.7 13.4 0.0011 19.7 0.3 6.3 6 0 0 6 6 6 4 WD domain, G-beta repeat Nup160 PF11715.8 EXF83548.1 - 0.014 14.0 2.2 0.021 13.5 0.0 2.0 2 0 0 2 2 2 0 Nucleoporin Nup120/160 Ribosomal_60s PF00428.19 EXF83548.1 - 0.82 10.3 30.1 2.5 8.7 2.5 4.4 4 0 0 4 4 4 0 60s Acidic ribosomal protein DEAD PF00270.29 EXF83549.1 - 9.2e-46 155.8 0.0 1.6e-45 155.1 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EXF83549.1 - 1e-22 80.5 0.0 8.6e-22 77.6 0.0 2.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EXF83549.1 - 6.4e-19 67.9 0.2 1.4e-18 66.9 0.2 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 EXF83549.1 - 0.00036 20.6 0.0 0.00096 19.2 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EXF83549.1 - 0.00051 19.3 0.0 0.001 18.4 0.0 1.4 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase SWIRM-assoc_2 PF16496.5 EXF83549.1 - 0.72 8.7 12.4 1.3 7.8 12.4 1.3 1 0 0 1 1 1 0 SWIRM-associated domain at the N-terminal Pox_Ag35 PF03286.14 EXF83549.1 - 7.9 6.2 16.1 14 5.4 16.1 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein 6PF2K PF01591.18 EXF83550.1 - 2.8e-79 265.5 0.2 3.8e-79 265.1 0.2 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 EXF83550.1 - 1.7e-35 122.5 0.0 2.6e-35 121.9 0.0 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 EXF83550.1 - 2.3e-06 27.8 0.0 5.3e-06 26.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.10 EXF83550.1 - 0.00025 20.6 0.0 0.00038 20.0 0.0 1.3 1 0 0 1 1 1 1 Chromatin associated protein KTI12 Glyco_hydro_26 PF02156.15 EXF83550.1 - 0.049 13.0 0.0 0.08 12.3 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 26 Asp PF00026.23 EXF83551.1 - 2.9e-38 132.1 0.4 4.3e-38 131.5 0.4 1.2 1 0 0 1 1 1 1 Eukaryotic aspartyl protease Asp_protease_2 PF13650.6 EXF83551.1 - 1.9e-06 28.4 0.2 0.041 14.5 0.1 3.4 3 0 0 3 3 3 2 Aspartyl protease gag-asp_proteas PF13975.6 EXF83551.1 - 0.023 15.2 0.1 3.2 8.4 0.1 3.0 2 1 0 2 2 2 0 gag-polyprotein putative aspartyl protease TAXi_N PF14543.6 EXF83551.1 - 0.051 13.8 0.8 4.9 7.4 1.0 3.1 2 1 0 2 2 2 0 Xylanase inhibitor N-terminal DUF829 PF05705.14 EXF83552.1 - 4.7e-39 134.7 0.0 7.1e-39 134.1 0.0 1.3 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF829) Ank_5 PF13857.6 EXF83553.1 - 1.5e-05 25.2 0.1 0.0059 16.9 0.0 2.8 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 EXF83553.1 - 0.00051 20.5 0.2 0.0028 18.2 0.0 2.3 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Helo_like_N PF17111.5 EXF83553.1 - 0.00056 19.3 1.5 0.00098 18.5 1.5 1.4 1 0 0 1 1 1 1 Fungal N-terminal domain of STAND proteins Ank_3 PF13606.6 EXF83553.1 - 0.0012 19.2 0.4 0.046 14.3 0.0 3.0 3 0 0 3 3 3 1 Ankyrin repeat Ank_2 PF12796.7 EXF83553.1 - 0.0024 18.4 0.0 0.018 15.6 0.0 2.1 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.30 EXF83553.1 - 0.078 13.5 0.1 0.3 11.6 0.0 2.1 2 0 0 2 2 2 0 Ankyrin repeat Clr5 PF14420.6 EXF83554.1 - 8.9e-12 45.0 0.1 2.1e-11 43.9 0.1 1.7 1 0 0 1 1 1 1 Clr5 domain DUF2039 PF10217.9 EXF83555.1 - 0.026 14.9 0.5 0.026 14.9 0.5 1.9 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2039) DUF5332 PF17266.2 EXF83555.1 - 0.46 10.2 5.0 0.15 11.7 0.9 1.8 1 1 1 2 2 2 0 Family of unknown function (DUF5332) KH_1 PF00013.29 EXF83556.1 - 9.4e-48 159.9 15.7 7.8e-17 60.9 0.8 3.3 3 0 0 3 3 3 3 KH domain KH_2 PF07650.17 EXF83556.1 - 5.4e-12 45.4 3.7 0.0041 16.9 0.0 3.4 3 0 0 3 3 3 3 KH domain KH_4 PF13083.6 EXF83556.1 - 4.7e-08 32.8 7.0 0.16 11.9 0.2 3.4 3 0 0 3 3 3 3 KH domain MOEP19 PF16005.5 EXF83556.1 - 0.0015 18.5 0.0 0.15 12.1 0.0 2.9 3 0 0 3 3 3 1 KH-like RNA-binding domain KH_5 PF13184.6 EXF83556.1 - 0.0076 16.3 5.7 10 6.3 0.1 3.7 3 1 0 3 3 3 3 NusA-like KH domain Baculo_PEP_C PF04513.12 EXF83559.1 - 0.012 15.7 13.9 0.05 13.6 1.2 3.9 3 2 1 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus ETRAMP PF09716.10 EXF83559.1 - 0.013 15.6 0.2 9.7 6.3 0.0 3.5 4 1 0 4 4 4 0 Malarial early transcribed membrane protein (ETRAMP) TMEM251 PF15190.6 EXF83559.1 - 0.079 12.9 0.9 0.32 11.0 0.9 2.1 1 1 0 1 1 1 0 Transmembrane protein 251 Trp_syntA PF00290.20 EXF83560.1 - 2.9e-84 282.0 0.6 4.1e-84 281.5 0.0 1.5 2 0 0 2 2 2 1 Tryptophan synthase alpha chain PALP PF00291.25 EXF83560.1 - 5.8e-49 167.1 2.3 9.8e-49 166.3 2.3 1.3 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Ribosomal_L28 PF00830.19 EXF83561.1 - 3.3e-19 68.8 2.2 5.4e-19 68.1 2.2 1.3 1 0 0 1 1 1 1 Ribosomal L28 family DUF3439 PF11921.8 EXF83561.1 - 0.1 12.6 3.1 0.17 11.8 3.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Tropomyosin_1 PF12718.7 EXF83562.1 - 0.13 12.4 4.7 0.63 10.2 1.2 2.3 1 1 1 2 2 2 0 Tropomyosin like Aminotran_1_2 PF00155.21 EXF83563.1 - 5.2e-90 302.2 0.0 6e-90 302.0 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Helo_like_N PF17111.5 EXF83564.1 - 7.4e-05 22.2 2.8 0.0001 21.8 0.9 2.1 1 1 1 2 2 2 1 Fungal N-terminal domain of STAND proteins Ank_2 PF12796.7 EXF83564.1 - 0.00086 19.8 0.1 0.02 15.4 0.0 2.9 3 0 0 3 3 3 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EXF83564.1 - 0.0017 18.6 0.0 2.1 8.7 0.0 3.4 2 1 1 3 3 3 1 Ankyrin repeats (many copies) Ank PF00023.30 EXF83564.1 - 0.017 15.6 0.2 0.23 12.0 0.0 3.0 3 0 0 3 3 3 0 Ankyrin repeat DUF720 PF05302.11 EXF83564.1 - 0.055 13.3 1.4 0.42 10.5 0.0 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF720) Ank_3 PF13606.6 EXF83564.1 - 0.13 12.9 0.0 29 5.7 0.0 3.7 3 0 0 3 3 3 0 Ankyrin repeat Baculo_PEP_C PF04513.12 EXF83564.1 - 2.4 8.2 9.9 1.3e+02 2.6 7.3 3.1 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus COG5 PF10392.9 EXF83564.1 - 6.8 6.9 6.8 9 6.5 0.9 2.5 1 1 1 2 2 2 0 Golgi transport complex subunit 5 LVIVD PF08309.11 EXF83565.1 - 0.00044 19.5 0.9 0.43 10.0 0.5 2.8 2 0 0 2 2 2 2 LVIVD repeat HsbA PF12296.8 EXF83567.1 - 2.9e-22 79.3 3.8 8.7e-21 74.6 1.3 2.3 2 0 0 2 2 2 2 Hydrophobic surface binding protein A Glyoxalase PF00903.25 EXF83568.1 - 6.6e-07 29.6 0.1 1.6e-06 28.4 0.1 1.5 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.7 EXF83568.1 - 0.0043 17.0 0.0 0.009 15.9 0.0 1.5 1 0 0 1 1 1 1 Glyoxalase-like domain GMC_oxred_N PF00732.19 EXF83571.1 - 1.3e-62 211.9 0.0 1.6e-62 211.6 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EXF83571.1 - 4.5e-32 111.6 0.0 9e-32 110.6 0.0 1.5 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.24 EXF83571.1 - 1e-07 31.4 0.1 0.00069 18.8 0.0 2.1 2 0 0 2 2 2 2 FAD binding domain Lycopene_cycl PF05834.12 EXF83571.1 - 0.00015 20.9 0.2 0.00023 20.3 0.2 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein NAD_binding_8 PF13450.6 EXF83571.1 - 0.00018 21.7 0.4 0.00038 20.6 0.4 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EXF83571.1 - 0.00026 20.3 0.3 0.0027 17.0 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EXF83571.1 - 0.0011 18.3 0.9 0.31 10.2 0.1 2.4 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EXF83571.1 - 0.0021 17.7 1.7 0.014 15.0 0.2 2.3 2 0 0 2 2 2 1 FAD dependent oxidoreductase HI0933_like PF03486.14 EXF83571.1 - 0.004 15.9 0.9 0.047 12.4 0.2 2.0 2 0 0 2 2 2 1 HI0933-like protein Thi4 PF01946.17 EXF83571.1 - 0.0077 15.5 0.3 0.024 13.9 0.0 1.8 2 0 0 2 2 2 1 Thi4 family TrkA_N PF02254.18 EXF83571.1 - 0.076 13.3 0.1 0.18 12.0 0.1 1.7 1 0 0 1 1 1 0 TrkA-N domain Trp_halogenase PF04820.14 EXF83571.1 - 0.12 11.2 0.6 0.17 10.7 0.6 1.1 1 0 0 1 1 1 0 Tryptophan halogenase FAD_binding_3 PF01494.19 EXF83571.1 - 0.12 11.5 0.2 0.22 10.8 0.2 1.3 1 0 0 1 1 1 0 FAD binding domain DUF2007 PF09413.10 EXF83571.1 - 0.14 12.3 0.3 0.81 9.9 0.1 2.4 2 0 0 2 2 2 0 Putative prokaryotic signal transducing protein GIDA PF01134.22 EXF83571.1 - 0.33 10.0 1.6 8.8 5.3 0.1 2.1 2 0 0 2 2 2 0 Glucose inhibited division protein A Cutinase PF01083.22 EXF83572.1 - 4.4e-44 150.6 0.0 5.7e-44 150.2 0.0 1.1 1 0 0 1 1 1 1 Cutinase PE-PPE PF08237.11 EXF83572.1 - 0.00016 21.3 0.0 0.00023 20.8 0.0 1.2 1 0 0 1 1 1 1 PE-PPE domain VirJ PF06057.11 EXF83572.1 - 0.0028 17.5 0.0 0.0043 17.0 0.0 1.2 1 0 0 1 1 1 1 Bacterial virulence protein (VirJ) DUF2974 PF11187.8 EXF83572.1 - 0.027 14.0 0.0 0.038 13.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Abhydrolase_1 PF00561.20 EXF83572.1 - 0.11 12.1 0.0 0.12 12.0 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold Ank_2 PF12796.7 EXF83573.1 - 2.8e-25 88.7 0.0 1.6e-11 44.6 0.1 3.7 2 2 2 4 4 4 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EXF83573.1 - 1.5e-15 55.7 0.2 0.048 14.2 0.0 6.1 6 0 0 6 6 6 4 Ankyrin repeat Ank_5 PF13857.6 EXF83573.1 - 1.6e-14 53.8 0.1 6.6e-05 23.1 0.0 4.5 4 2 2 6 6 6 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 EXF83573.1 - 2.5e-11 43.9 0.7 0.00014 22.3 0.0 4.6 3 1 2 5 5 5 3 Ankyrin repeats (many copies) Ank PF00023.30 EXF83573.1 - 2.9e-11 43.3 0.2 0.51 10.9 0.0 5.9 6 0 0 6 6 6 5 Ankyrin repeat NACHT PF05729.12 EXF83574.1 - 0.0013 18.7 0.0 0.0023 17.9 0.0 1.4 1 1 0 1 1 1 1 NACHT domain KAP_NTPase PF07693.14 EXF83574.1 - 0.0051 16.1 0.0 0.0079 15.5 0.0 1.4 1 0 0 1 1 1 1 KAP family P-loop domain Peroxidase_2 PF01328.17 EXF83575.1 - 1.3e-52 179.0 0.0 1.6e-52 178.8 0.0 1.0 1 0 0 1 1 1 1 Peroxidase, family 2 Epimerase PF01370.21 EXF83576.1 - 6.7e-05 22.5 0.0 0.014 14.9 0.0 2.2 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.24 EXF83576.1 - 0.033 14.6 0.0 0.076 13.4 0.0 1.6 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain Sacchrp_dh_NADP PF03435.18 EXF83576.1 - 0.048 13.9 0.0 0.09 13.0 0.0 1.5 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain DUF4381 PF14316.6 EXF83577.1 - 0.00098 19.4 0.5 0.0024 18.1 0.2 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4381) Herpes_gE PF02480.16 EXF83577.1 - 0.092 11.5 0.0 0.15 10.8 0.0 1.2 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E AAA PF00004.29 EXF83578.1 - 9.2e-08 32.6 0.1 4e-07 30.5 0.1 2.0 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EXF83578.1 - 0.027 14.2 0.0 0.044 13.5 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain TsaE PF02367.17 EXF83578.1 - 0.079 13.0 0.4 1.4 8.9 0.0 2.6 3 0 0 3 3 3 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE T2SSE PF00437.20 EXF83578.1 - 0.093 11.8 0.0 0.17 10.9 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_16 PF13191.6 EXF83578.1 - 0.13 12.7 1.5 0.31 11.4 0.3 2.0 1 1 1 2 2 2 0 AAA ATPase domain HsbA PF12296.8 EXF83580.1 - 8.2e-24 84.3 17.6 1.4e-23 83.6 17.6 1.4 1 0 0 1 1 1 1 Hydrophobic surface binding protein A DUF2076 PF09849.9 EXF83580.1 - 0.15 12.1 3.7 0.045 13.8 0.9 1.6 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2076) DUF2379 PF09543.10 EXF83580.1 - 1.9 8.7 4.5 0.64 10.2 0.8 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2379) DUF3112 PF11309.8 EXF83581.1 - 6.1e-08 32.4 13.9 3.2e-07 30.0 0.1 2.9 2 1 1 3 3 3 2 Protein of unknown function (DUF3112) DUF3671 PF12420.8 EXF83581.1 - 0.099 12.7 0.2 1.2 9.2 0.9 2.2 2 0 0 2 2 2 0 Protein of unknown function Ndc1_Nup PF09531.10 EXF83581.1 - 0.22 10.2 6.1 0.14 10.8 0.8 2.2 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup Abhydrolase_3 PF07859.13 EXF83582.1 - 7.4e-56 189.3 0.1 9.7e-56 188.9 0.1 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 EXF83582.1 - 1.6e-06 27.3 0.2 7.7e-06 25.0 0.2 1.8 1 1 0 1 1 1 1 Carboxylesterase family Esterase_phd PF10503.9 EXF83582.1 - 0.016 14.7 0.6 0.073 12.6 0.1 2.0 2 0 0 2 2 2 0 Esterase PHB depolymerase Peptidase_S9 PF00326.21 EXF83582.1 - 0.026 14.0 0.2 0.1 12.0 0.1 1.8 2 0 0 2 2 2 0 Prolyl oligopeptidase family HCO3_cotransp PF00955.21 EXF83583.1 - 0.0054 15.6 0.9 0.0079 15.1 0.9 1.1 1 0 0 1 1 1 1 HCO3- transporter family Ly49 PF08391.10 EXF83583.1 - 0.17 12.2 0.4 0.36 11.2 0.4 1.5 1 0 0 1 1 1 0 Ly49-like protein, N-terminal region DPBB_1 PF03330.18 EXF83584.1 - 4e-08 33.4 0.1 1.4e-07 31.7 0.0 2.0 2 0 0 2 2 2 1 Lytic transglycolase Barwin PF00967.17 EXF83584.1 - 1.3e-05 25.0 0.2 2.5e-05 24.1 0.2 1.4 1 0 0 1 1 1 1 Barwin family Zip PF02535.22 EXF83588.1 - 6.1e-49 167.0 2.9 9.8e-49 166.4 2.9 1.3 1 0 0 1 1 1 1 ZIP Zinc transporter Fungal_trans_2 PF11951.8 EXF83589.1 - 6.9e-08 31.7 0.0 1.1e-07 31.0 0.0 1.3 1 1 0 1 1 1 1 Fungal specific transcription factor domain PhyH PF05721.13 EXF83590.1 - 1.8e-09 38.2 0.0 5.1e-09 36.7 0.0 1.8 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) NPP1 PF05630.11 EXF83591.1 - 3.4e-48 164.4 0.0 5e-48 163.8 0.0 1.2 1 0 0 1 1 1 1 Necrosis inducing protein (NPP1) NPP1 PF05630.11 EXF83593.1 - 8.3e-41 140.3 0.0 1.1e-40 139.9 0.0 1.1 1 0 0 1 1 1 1 Necrosis inducing protein (NPP1) NPP1 PF05630.11 EXF83594.1 - 2.6e-50 171.3 0.0 3.1e-50 171.0 0.0 1.1 1 0 0 1 1 1 1 Necrosis inducing protein (NPP1) SKG6 PF08693.10 EXF83595.1 - 0.00016 21.0 0.5 0.00029 20.2 0.5 1.5 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Phage_holin_3_6 PF07332.11 EXF83595.1 - 0.087 12.9 0.1 0.12 12.4 0.1 1.1 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III Glyco_hydro_cc PF11790.8 EXF83596.1 - 1e-60 205.3 0.0 1.2e-60 205.0 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core FMN_red PF03358.15 EXF83598.1 - 7.2e-24 84.3 0.0 9.9e-24 83.8 0.0 1.1 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 EXF83598.1 - 1.4e-05 24.9 0.0 1.8e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin-like fold preATP-grasp_3 PF18301.1 EXF83598.1 - 0.088 13.1 0.0 0.17 12.2 0.0 1.5 1 0 0 1 1 1 0 pre ATP-grasp 3 domain Asp PF00026.23 EXF83599.1 - 7.4e-37 127.4 0.1 4.8e-36 124.8 0.1 2.0 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EXF83599.1 - 1e-07 32.4 1.5 1e-07 32.4 1.5 1.8 2 0 0 2 2 2 1 Xylanase inhibitor N-terminal CcmD PF04995.14 EXF83599.1 - 0.0013 18.7 0.4 0.0023 18.0 0.4 1.4 1 0 0 1 1 1 1 Heme exporter protein D (CcmD) LapA_dom PF06305.11 EXF83599.1 - 0.018 14.9 0.0 0.038 13.8 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain Glyco_hydro_18 PF00704.28 EXF83600.1 - 4.3e-87 292.7 4.3 5e-87 292.5 4.3 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Methyltransf_23 PF13489.6 EXF83601.1 - 7.9e-12 45.3 0.0 2.8e-11 43.5 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF83601.1 - 9.2e-07 28.8 0.1 0.00017 21.5 0.0 2.3 1 1 1 2 2 2 2 Methyltransferase domain Methyltransf_25 PF13649.6 EXF83601.1 - 6.1e-05 23.7 0.2 0.006 17.3 0.0 2.7 2 1 1 3 3 3 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF83601.1 - 0.00017 22.3 0.1 0.012 16.3 0.0 2.9 2 1 1 3 3 3 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF83601.1 - 0.00079 20.0 0.0 0.006 17.2 0.0 2.4 2 1 0 2 2 2 1 Methyltransferase domain BTB PF00651.31 EXF83602.1 - 0.11 12.8 0.0 0.2 11.9 0.0 1.5 1 1 1 2 2 2 0 BTB/POZ domain DUF1411 PF07199.11 EXF83602.1 - 0.14 11.8 0.0 0.17 11.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1411) N2227 PF07942.12 EXF83607.1 - 4.2e-58 196.7 0.0 5.4e-58 196.3 0.0 1.1 1 0 0 1 1 1 1 N2227-like protein Methyltransf_11 PF08241.12 EXF83607.1 - 5.8e-11 42.9 0.0 7.6e-09 36.1 0.0 2.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF83607.1 - 6.6e-10 39.6 0.1 5.6e-06 27.0 0.0 2.6 1 1 1 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 EXF83607.1 - 4.7e-07 30.5 0.1 8.6e-06 26.4 0.1 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EXF83607.1 - 1.7e-06 28.0 0.0 2.7e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF83607.1 - 9.6e-06 25.5 0.1 0.0038 17.0 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain TPMT PF05724.11 EXF83607.1 - 0.0085 15.8 0.1 0.031 13.9 0.1 2.0 1 1 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) TehB PF03848.14 EXF83607.1 - 0.014 14.8 0.0 0.037 13.4 0.0 1.6 2 0 0 2 2 2 0 Tellurite resistance protein TehB Ubie_methyltran PF01209.18 EXF83607.1 - 0.045 13.1 0.0 0.12 11.7 0.0 1.7 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family Methyltransf_8 PF05148.15 EXF83607.1 - 0.062 13.1 0.0 0.15 11.8 0.0 1.6 2 0 0 2 2 2 0 Hypothetical methyltransferase Tyrosinase PF00264.20 EXF83608.1 - 6.3e-40 137.8 11.2 1.5e-39 136.6 11.2 1.6 1 1 0 1 1 1 1 Common central domain of tyrosinase DUF3328 PF11807.8 EXF83609.1 - 6.2e-23 81.7 5.3 4e-22 79.1 5.3 2.2 1 1 0 1 1 1 1 Domain of unknown function (DUF3328) CD225 PF04505.12 EXF83609.1 - 0.15 12.2 0.6 0.27 11.4 0.6 1.4 1 0 0 1 1 1 0 Interferon-induced transmembrane protein DUF5050 PF16472.5 EXF83610.1 - 8e-05 22.0 4.8 9.6e-05 21.8 0.9 2.3 1 1 1 2 2 2 2 Domain of unknown function (DUF5050) Cadherin_4 PF17803.1 EXF83610.1 - 0.00037 21.1 11.6 99 3.7 0.1 7.1 2 1 5 7 7 7 0 Bacterial cadherin-like domain LytTR PF04397.15 EXF83610.1 - 0.0021 18.2 3.7 35 4.7 0.0 4.6 2 1 6 8 8 8 0 LytTr DNA-binding domain Transposase_23 PF03017.14 EXF83610.1 - 0.004 17.1 0.0 31 4.6 0.0 5.6 7 0 0 7 7 7 0 TNP1/EN/SPM transposase DUF3906 PF13046.6 EXF83610.1 - 0.0044 17.1 23.4 60 3.8 0.1 8.5 2 1 7 9 9 9 0 Protein of unknown function (DUF3906) THDPS_M PF14789.6 EXF83610.1 - 0.36 11.0 20.1 2.5e+02 1.9 0.0 9.3 10 0 0 10 10 10 0 Tetrahydrodipicolinate N-succinyltransferase middle Arm-DNA-bind_1 PF09003.10 EXF83611.1 - 0.08 13.1 0.0 0.14 12.3 0.0 1.3 1 0 0 1 1 1 0 Bacteriophage lambda integrase, Arm DNA-binding domain But2 PF09792.9 EXF83612.1 - 0.00053 20.4 0.0 0.0011 19.4 0.0 1.5 1 1 0 1 1 1 1 Ubiquitin 3 binding protein But2 C-terminal domain Methyltransf_25 PF13649.6 EXF83613.1 - 1.5e-07 32.1 0.0 3.4e-07 30.9 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 EXF83613.1 - 5.6e-05 23.0 0.0 9.4e-05 22.2 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 EXF83613.1 - 6.5e-05 22.8 0.0 0.00022 21.1 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF83613.1 - 0.00041 20.9 0.0 0.00093 19.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EXF83613.1 - 0.0015 18.4 0.1 0.0027 17.6 0.0 1.4 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 EXF83613.1 - 0.002 17.5 0.0 0.0026 17.2 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 EXF83613.1 - 0.02 15.7 0.0 0.09 13.5 0.0 2.2 2 1 0 2 2 2 0 Methyltransferase domain MetW PF07021.12 EXF83613.1 - 0.036 13.6 0.1 0.28 10.7 0.0 2.2 3 0 0 3 3 3 0 Methionine biosynthesis protein MetW Fibrillarin PF01269.17 EXF83613.1 - 0.083 12.0 0.0 0.13 11.4 0.0 1.2 1 0 0 1 1 1 0 Fibrillarin Methyltr_RsmB-F PF01189.17 EXF83613.1 - 0.14 11.8 0.1 0.25 10.9 0.1 1.3 1 0 0 1 1 1 0 16S rRNA methyltransferase RsmB/F MTS PF05175.14 EXF83613.1 - 0.2 11.2 0.0 0.3 10.6 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Glyco_hydro_3 PF00933.21 EXF83615.1 - 9e-57 192.8 0.0 1.4e-56 192.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.22 EXF83615.1 - 9.7e-54 182.4 0.0 2.8e-53 180.9 0.0 1.8 2 1 0 2 2 2 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.6 EXF83615.1 - 1.2e-20 73.4 0.2 3.2e-20 72.0 0.1 1.9 2 0 0 2 2 2 1 Fibronectin type III-like domain PA14 PF07691.12 EXF83615.1 - 2.6e-06 27.3 0.0 6.6e-06 26.0 0.0 1.6 1 0 0 1 1 1 1 PA14 domain CARDB PF07705.11 EXF83615.1 - 0.15 12.3 0.0 0.38 11.1 0.0 1.6 1 0 0 1 1 1 0 CARDB FtsX PF02687.21 EXF83616.1 - 0.0051 17.2 0.6 0.0051 17.2 0.6 3.2 2 2 0 2 2 2 1 FtsX-like permease family Uds1 PF15456.6 EXF83617.1 - 0.043 14.0 1.1 0.043 14.0 1.1 2.4 2 1 0 2 2 2 0 Up-regulated During Septation SCO1-SenC PF02630.14 EXF83617.1 - 0.14 12.1 0.0 0.32 10.9 0.0 1.6 1 0 0 1 1 1 0 SCO1/SenC INCENP_ARK-bind PF03941.15 EXF83617.1 - 0.51 10.3 9.4 0.097 12.6 1.3 2.7 2 0 0 2 2 2 0 Inner centromere protein, ARK binding region Cytochrom_B562 PF07361.11 EXF83618.1 - 0.0047 17.6 2.0 0.0058 17.3 0.2 2.1 2 0 0 2 2 2 1 Cytochrome b562 ADH_zinc_N PF00107.26 EXF83619.1 - 3e-24 85.4 0.0 4.6e-24 84.9 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EXF83619.1 - 5.4e-20 71.3 2.4 8.6e-20 70.7 2.4 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain 2-Hacid_dh_C PF02826.19 EXF83619.1 - 0.0014 18.0 0.1 0.0023 17.3 0.1 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Glu_dehyd_C PF16912.5 EXF83619.1 - 0.0016 18.0 0.1 0.0023 17.4 0.1 1.2 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus MFS_1 PF07690.16 EXF83620.1 - 3.9e-15 55.6 14.2 5.9e-15 55.0 14.2 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF5360 PF17314.2 EXF83620.1 - 0.038 14.0 1.8 0.075 13.1 0.4 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5360) DUF4131 PF13567.6 EXF83620.1 - 0.15 11.7 1.2 0.51 10.0 0.0 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4131) DUF1127 PF06568.11 EXF83620.1 - 0.17 11.7 0.2 0.17 11.7 0.2 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1127) Albumin_I PF08027.11 EXF83620.1 - 0.27 10.9 1.5 0.53 9.9 1.5 1.5 1 0 0 1 1 1 0 Albumin I chain b TraL PF07178.11 EXF83620.1 - 4 8.0 6.0 0.39 11.2 0.2 2.3 3 0 0 3 3 3 0 TraL protein NAD_binding_8 PF13450.6 EXF83622.1 - 7.2e-15 55.0 0.0 1.7e-14 53.8 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 EXF83622.1 - 3.9e-07 29.7 0.2 8.2e-06 25.4 0.0 2.1 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase DAO PF01266.24 EXF83622.1 - 3.8e-05 23.5 0.0 8.3e-05 22.3 0.0 1.7 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EXF83622.1 - 0.033 13.4 0.0 0.053 12.7 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EXF83622.1 - 0.035 14.1 0.0 0.37 10.8 0.0 2.6 2 1 1 3 3 3 0 FAD-NAD(P)-binding Pyr_redox PF00070.27 EXF83622.1 - 0.068 13.7 0.0 0.31 11.6 0.0 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EXF83622.1 - 0.084 11.9 0.0 0.13 11.3 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain Trp_halogenase PF04820.14 EXF83622.1 - 0.1 11.5 0.0 0.14 11.0 0.0 1.1 1 0 0 1 1 1 0 Tryptophan halogenase FAD_binding_2 PF00890.24 EXF83623.1 - 9.7e-38 130.3 0.9 1.9e-37 129.3 0.9 1.5 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.24 EXF83623.1 - 3.9e-12 46.4 1.5 1e-10 41.7 1.5 2.8 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_oxidored PF12831.7 EXF83623.1 - 5.5e-07 29.3 1.4 8.7e-07 28.6 1.4 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 EXF83623.1 - 1.7e-05 23.8 2.8 6.7e-05 21.8 0.2 2.4 2 1 0 2 2 2 1 HI0933-like protein Pyr_redox_2 PF07992.14 EXF83623.1 - 8.3e-05 21.9 2.3 0.00015 21.1 0.2 2.2 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EXF83623.1 - 0.00012 22.3 2.3 0.00032 20.9 2.3 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 EXF83623.1 - 0.006 15.7 5.3 0.006 15.7 5.3 2.6 3 0 0 3 3 3 1 Glucose inhibited division protein A Thi4 PF01946.17 EXF83623.1 - 0.007 15.6 2.2 0.015 14.5 2.2 1.5 1 0 0 1 1 1 1 Thi4 family AlaDh_PNT_C PF01262.21 EXF83623.1 - 0.046 13.0 0.1 0.092 12.0 0.1 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox_3 PF13738.6 EXF83623.1 - 8.4 5.5 6.4 9.7 5.3 3.3 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_4 PF07993.12 EXF83624.1 - 3.5e-43 147.6 0.0 6.4e-43 146.8 0.0 1.4 1 0 0 1 1 1 1 Male sterility protein AMP-binding PF00501.28 EXF83624.1 - 1.1e-29 103.4 0.0 3.3e-27 95.2 0.0 2.3 2 0 0 2 2 2 2 AMP-binding enzyme PP-binding PF00550.25 EXF83624.1 - 5e-11 42.8 0.0 2.1e-10 40.8 0.0 2.2 2 0 0 2 2 2 1 Phosphopantetheine attachment site Epimerase PF01370.21 EXF83624.1 - 1.7e-10 40.8 0.0 2.9e-10 40.0 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family KR PF08659.10 EXF83624.1 - 0.0015 18.5 0.1 0.01 15.8 0.0 2.3 2 1 0 2 2 2 1 KR domain 3Beta_HSD PF01073.19 EXF83624.1 - 0.018 14.1 0.0 0.034 13.2 0.0 1.4 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 EXF83624.1 - 0.079 12.3 0.0 0.16 11.4 0.0 1.5 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Transp_cyt_pur PF02133.15 EXF83625.1 - 2.6e-100 336.3 34.5 3e-100 336.1 34.5 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin S1FA PF04689.13 EXF83625.1 - 1 9.6 4.7 0.21 11.8 0.3 2.2 2 0 0 2 2 2 0 DNA binding protein S1FA Fungal_trans PF04082.18 EXF83626.1 - 1.8e-17 63.2 1.0 3.5e-17 62.3 1.0 1.5 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF83626.1 - 0.00013 22.0 6.0 0.00029 20.9 6.0 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CN_hydrolase PF00795.22 EXF83627.1 - 5e-45 153.9 0.0 1.1e-44 152.7 0.0 1.6 2 0 0 2 2 2 1 Carbon-nitrogen hydrolase Asp_Glu_race PF01177.22 EXF83627.1 - 1.8e-10 41.1 0.1 3e-10 40.3 0.1 1.3 1 0 0 1 1 1 1 Asp/Glu/Hydantoin racemase Amdase PF17645.1 EXF83627.1 - 0.0055 16.4 1.4 0.011 15.3 0.8 1.6 1 1 0 2 2 2 1 Arylmalonate decarboxylase Dimerisation2 PF16864.5 EXF83627.1 - 0.021 14.8 0.2 0.11 12.5 0.1 2.1 2 0 0 2 2 2 0 Dimerisation domain Amidohydro_1 PF01979.20 EXF83628.1 - 3.7e-24 85.7 0.0 8.8e-24 84.4 0.0 1.7 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EXF83628.1 - 5.4e-15 55.8 1.1 5.5e-07 29.4 0.0 2.6 3 0 0 3 3 3 2 Amidohydrolase family Urease_alpha PF00449.20 EXF83628.1 - 0.019 15.3 1.1 0.042 14.2 0.3 2.0 2 0 0 2 2 2 0 Urease alpha-subunit, N-terminal domain AAA_33 PF13671.6 EXF83628.1 - 0.15 12.3 0.0 0.31 11.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain HET PF06985.11 EXF83629.1 - 9.7e-23 81.1 0.0 1.9e-22 80.2 0.0 1.5 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Abhydrolase_1 PF00561.20 EXF83630.1 - 3.7e-12 46.5 0.0 5.1e-08 32.9 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EXF83630.1 - 2.2e-08 35.0 0.0 2.7e-08 34.7 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EXF83630.1 - 5.2e-06 25.9 0.0 0.0057 16.0 0.0 2.0 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Ndr PF03096.14 EXF83630.1 - 0.00024 19.9 0.0 0.00054 18.8 0.0 1.6 1 1 0 1 1 1 1 Ndr family p450 PF00067.22 EXF83633.1 - 4.7e-41 141.0 0.0 9.7e-38 130.1 0.0 3.2 1 1 0 1 1 1 1 Cytochrome P450 Cnn_1N PF07989.11 EXF83634.1 - 9e-10 38.6 8.5 2.5e-09 37.2 8.5 1.7 1 0 0 1 1 1 1 Centrosomin N-terminal motif 1 ESP PF16590.5 EXF83634.1 - 0.019 15.2 0.9 0.056 13.7 0.4 1.9 1 1 1 2 2 2 0 Exocrine gland-secreting peptide DUF4164 PF13747.6 EXF83634.1 - 0.41 11.0 7.2 0.86 9.9 7.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) Cep57_CLD_2 PF14197.6 EXF83634.1 - 0.69 10.0 9.0 0.36 10.9 6.3 1.9 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 bZIP_1 PF00170.21 EXF83634.1 - 3.4 7.8 10.0 0.45 10.6 2.3 2.8 2 1 1 3 3 3 0 bZIP transcription factor APG6_N PF17675.1 EXF83634.1 - 5.4 7.6 9.1 12 6.5 9.1 1.5 1 0 0 1 1 1 0 Apg6 coiled-coil region ABC_tran_CTD PF16326.5 EXF83634.1 - 6.7 7.0 8.1 15 5.9 8.1 1.5 1 0 0 1 1 1 0 ABC transporter C-terminal domain PepX_C PF08530.10 EXF83636.1 - 4.1e-36 125.0 0.0 5.8e-36 124.5 0.0 1.2 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain Peptidase_S15 PF02129.18 EXF83636.1 - 6e-35 121.1 4.5 1.9e-29 103.1 0.0 2.1 1 1 1 2 2 2 2 X-Pro dipeptidyl-peptidase (S15 family) PhyH PF05721.13 EXF83637.1 - 0.00015 22.1 0.1 0.0002 21.7 0.1 1.2 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) 2OG-FeII_Oxy_5 PF13759.6 EXF83637.1 - 0.0054 17.1 0.0 0.01 16.2 0.0 1.4 1 0 0 1 1 1 1 Putative 2OG-Fe(II) oxygenase 2OG-FeII_Oxy_3 PF13640.6 EXF83637.1 - 0.05 14.5 0.0 0.13 13.2 0.0 1.6 2 0 0 2 2 2 0 2OG-Fe(II) oxygenase superfamily DUF1479 PF07350.12 EXF83637.1 - 0.068 11.9 0.0 0.88 8.3 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1479) MFS_1 PF07690.16 EXF83638.1 - 4.9e-19 68.5 20.5 4.9e-19 68.5 20.5 2.2 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF83638.1 - 9.7e-06 24.7 11.6 9.7e-06 24.7 11.6 2.5 2 1 0 2 2 2 1 Sugar (and other) transporter Fungal_trans PF04082.18 EXF83639.1 - 3.8e-12 45.8 0.0 6.6e-12 45.0 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF83639.1 - 1.2e-08 34.9 10.2 2.4e-08 33.9 10.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Peroxidase_2 PF01328.17 EXF83640.1 - 3.5e-44 151.6 0.0 4.6e-44 151.2 0.0 1.1 1 0 0 1 1 1 1 Peroxidase, family 2 Aa_trans PF01490.18 EXF83641.1 - 2.2e-34 118.9 31.2 2.5e-34 118.7 31.2 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Herpes_UL79 PF03049.14 EXF83641.1 - 0.17 11.5 0.2 0.3 10.7 0.2 1.3 1 0 0 1 1 1 0 UL79 family BTB PF00651.31 EXF83642.1 - 0.00098 19.3 0.0 0.0023 18.2 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain GGACT PF06094.12 EXF83643.1 - 3.2e-09 37.4 0.9 1.4e-08 35.4 0.1 2.1 2 0 0 2 2 2 1 Gamma-glutamyl cyclotransferase, AIG2-like PAS_6 PF08348.11 EXF83643.1 - 0.18 11.6 0.2 0.45 10.4 0.2 1.6 1 0 0 1 1 1 0 YheO-like PAS domain zf-RING_2 PF13639.6 EXF83644.1 - 1.2e-13 51.1 6.2 1.7e-13 50.6 6.2 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EXF83644.1 - 9.1e-11 41.4 7.0 1.4e-10 40.9 7.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EXF83644.1 - 4.6e-10 39.2 3.9 7.4e-10 38.5 3.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EXF83644.1 - 3.5e-09 36.5 5.4 6.3e-09 35.7 5.4 1.4 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EXF83644.1 - 9.6e-09 35.0 3.3 1.5e-08 34.3 3.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EXF83644.1 - 3.2e-07 30.2 4.9 7e-07 29.1 5.0 1.5 1 1 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EXF83644.1 - 4.8e-07 29.5 8.9 7.2e-07 29.0 3.4 2.2 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 EXF83644.1 - 5.8e-06 26.4 7.3 1.5e-05 25.1 7.3 1.7 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_11 PF17123.5 EXF83644.1 - 1.8e-05 24.3 2.7 3.2e-05 23.6 2.7 1.4 1 0 0 1 1 1 1 RING-like zinc finger zf-rbx1 PF12678.7 EXF83644.1 - 7.6e-05 22.9 10.0 0.00038 20.7 10.0 2.0 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 EXF83644.1 - 0.00064 19.7 0.9 0.00099 19.1 0.9 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Rad50_zn_hook PF04423.14 EXF83644.1 - 0.004 16.9 0.4 0.34 10.8 0.0 2.2 2 0 0 2 2 2 1 Rad50 zinc hook motif Phage_holin_3_6 PF07332.11 EXF83644.1 - 0.011 15.8 0.1 0.017 15.2 0.1 1.3 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III Vps39_2 PF10367.9 EXF83644.1 - 0.066 13.7 1.8 0.067 13.7 0.5 1.6 2 0 0 2 2 2 0 Vacuolar sorting protein 39 domain 2 Zn_ribbon_17 PF17120.5 EXF83644.1 - 0.079 12.6 4.4 0.13 11.9 4.4 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type DUF2225 PF09986.9 EXF83644.1 - 0.12 12.0 0.3 1.6 8.4 0.1 2.0 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) zf-RING_4 PF14570.6 EXF83644.1 - 0.13 12.1 7.0 1.2 9.0 7.1 2.1 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain FdhE PF04216.12 EXF83644.1 - 0.22 11.4 2.4 0.34 10.8 2.4 1.2 1 0 0 1 1 1 0 Protein involved in formate dehydrogenase formation zf-P11 PF03854.14 EXF83644.1 - 0.3 10.8 5.8 0.23 11.2 3.1 2.0 2 0 0 2 2 2 0 P-11 zinc finger FYVE PF01363.21 EXF83644.1 - 0.34 11.1 5.0 1.6 8.9 5.0 2.1 1 1 0 1 1 1 0 FYVE zinc finger zf-RING_6 PF14835.6 EXF83644.1 - 0.92 9.4 5.8 2.2 8.2 5.8 1.7 1 1 0 1 1 1 0 zf-RING of BARD1-type protein C1_2 PF03107.16 EXF83644.1 - 1.1 9.6 9.0 0.69 10.3 4.9 2.5 2 1 0 2 2 2 0 C1 domain zf-H2C2_2 PF13465.6 EXF83644.1 - 2.1 8.9 6.2 16 6.1 0.6 2.9 3 0 0 3 3 2 0 Zinc-finger double domain PGAP1 PF07819.13 EXF83646.1 - 0.0019 17.9 0.0 0.0045 16.8 0.0 1.5 1 1 0 1 1 1 1 PGAP1-like protein Abhydrolase_6 PF12697.7 EXF83646.1 - 0.009 16.6 0.1 0.02 15.5 0.1 1.6 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EXF83646.1 - 0.089 12.0 0.0 0.77 9.0 0.0 2.3 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Asp PF00026.23 EXF83647.1 - 6.7e-39 134.2 0.9 8.6e-39 133.8 0.9 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EXF83647.1 - 3.1e-06 27.5 0.6 0.00018 21.8 0.1 3.0 2 1 1 3 3 3 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EXF83647.1 - 0.0085 16.7 0.9 4.8 7.9 0.0 3.2 3 0 0 3 3 3 2 Aspartyl protease Glyco_hydro2_C5 PF18565.1 EXF83648.1 - 3.2e-34 116.8 0.5 6.2e-34 115.9 0.5 1.5 1 0 0 1 1 1 1 Glycoside hydrolase family 2 C-terminal domain 5 Glyco_hydro_2_C PF02836.17 EXF83648.1 - 1.3e-24 86.9 0.1 3.3e-24 85.5 0.0 1.6 2 0 0 2 2 2 1 Glycosyl hydrolases family 2, TIM barrel domain DUF4982 PF16355.5 EXF83648.1 - 1.6e-22 79.2 0.1 3.6e-22 78.1 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4982) Glyco_hydro_2_N PF02837.18 EXF83648.1 - 9e-14 51.7 0.0 2.9e-13 50.1 0.0 1.9 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2 PF00703.21 EXF83648.1 - 3e-13 50.4 0.1 7e-13 49.2 0.1 1.7 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 BetaGal_dom4_5 PF13364.6 EXF83648.1 - 2.6e-06 28.0 0.1 7.3e-05 23.3 0.0 3.1 3 0 0 3 3 3 1 Beta-galactosidase jelly roll domain Invasin_D3 PF09134.10 EXF83648.1 - 4.6e-05 23.6 0.4 4.6e-05 23.6 0.4 3.1 2 1 0 2 2 2 1 Invasin, domain 3 Big_1 PF02369.16 EXF83648.1 - 0.0041 17.1 1.0 0.0041 17.1 1.0 2.6 2 0 0 2 2 2 1 Bacterial Ig-like domain (group 1) Acetyltransf_1 PF00583.25 EXF83650.1 - 3.6e-09 36.9 0.0 5.1e-09 36.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EXF83650.1 - 9.4e-06 26.0 0.0 1.4e-05 25.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EXF83650.1 - 7.1e-05 22.7 0.0 0.00012 22.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EXF83651.1 - 4.6e-06 26.9 0.0 8.2e-06 26.0 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EXF83651.1 - 0.051 14.0 0.0 0.095 13.1 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain LCCL PF03815.19 EXF83652.1 - 7.3e-21 74.1 0.0 1.3e-20 73.3 0.0 1.3 1 0 0 1 1 1 1 LCCL domain Sugar_tr PF00083.24 EXF83654.1 - 2.4e-71 241.0 20.3 2.9e-71 240.7 20.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF83654.1 - 1.2e-25 90.2 27.0 1.7e-25 89.7 27.0 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily 7tm_1 PF00001.21 EXF83654.1 - 0.023 14.0 0.7 0.043 13.1 0.7 1.5 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) Flavin_Reduct PF01613.18 EXF83656.1 - 1e-17 64.6 0.0 1.4e-17 64.1 0.0 1.1 1 0 0 1 1 1 1 Flavin reductase like domain Peptidase_S8 PF00082.22 EXF83657.1 - 3.7e-32 111.8 10.6 5.5e-32 111.2 10.7 1.3 1 1 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 EXF83657.1 - 5.1e-16 59.1 0.2 5.1e-16 59.1 0.2 1.7 2 0 0 2 2 2 1 Peptidase inhibitor I9 Hydrolase_4 PF12146.8 EXF83660.1 - 1.4e-11 44.2 0.2 4.2e-10 39.3 0.2 2.3 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EXF83660.1 - 5.2e-10 40.3 2.3 9e-10 39.5 2.3 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EXF83660.1 - 1.7e-06 27.9 0.1 0.0013 18.4 0.0 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EXF83660.1 - 6.5e-05 22.5 0.9 0.16 11.4 0.2 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family LIP PF03583.14 EXF83660.1 - 0.00028 20.3 0.4 0.013 14.8 0.1 2.1 2 0 0 2 2 2 2 Secretory lipase DLH PF01738.18 EXF83660.1 - 0.00061 19.4 0.1 0.029 13.9 0.0 2.1 2 0 0 2 2 2 1 Dienelactone hydrolase family PAS_9 PF13426.7 EXF83662.1 - 6e-18 65.0 0.0 2.8e-14 53.2 0.0 2.6 2 0 0 2 2 2 2 PAS domain RGS PF00615.19 EXF83662.1 - 5.7e-12 45.9 0.2 1.5e-11 44.6 0.2 1.6 1 0 0 1 1 1 1 Regulator of G protein signaling domain PAS_4 PF08448.10 EXF83662.1 - 0.0059 16.9 0.3 4.7 7.5 0.0 3.2 3 0 0 3 3 3 2 PAS fold PAS_3 PF08447.12 EXF83662.1 - 0.015 15.6 2.0 0.15 12.4 0.0 2.9 3 0 0 3 3 3 0 PAS fold Glyco_hydro_61 PF03443.14 EXF83663.1 - 0.00092 19.2 0.0 0.003 17.5 0.0 1.7 2 0 0 2 2 2 1 Glycosyl hydrolase family 61 ATP-synt_ab PF00006.25 EXF83663.1 - 0.071 12.7 0.1 0.79 9.3 0.0 1.9 1 1 1 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain MaoC_dehydratas PF01575.19 EXF83663.1 - 0.091 12.3 0.0 0.16 11.6 0.0 1.4 1 0 0 1 1 1 0 MaoC like domain HAD_2 PF13419.6 EXF83664.1 - 2.5e-10 40.7 0.0 3.1e-10 40.4 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EXF83664.1 - 2e-09 38.1 0.0 2.3e-09 37.8 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EXF83664.1 - 7.2e-06 26.0 0.0 1.2e-05 25.3 0.0 1.3 1 0 0 1 1 1 1 HAD-hyrolase-like Acid_PPase PF12689.7 EXF83664.1 - 0.1 12.4 0.0 0.14 12.0 0.0 1.2 1 0 0 1 1 1 0 Acid Phosphatase Glyco_hydro_7 PF00840.20 EXF83665.1 - 6.5e-198 657.8 22.2 7.4e-198 657.6 22.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 7 Egh16-like PF11327.8 EXF83666.1 - 1.7e-53 181.8 14.0 1.7e-53 181.8 14.0 1.6 2 0 0 2 2 2 1 Egh16-like virulence factor DUF1264 PF06884.11 EXF83667.1 - 1.1e-77 259.5 0.2 1.3e-77 259.3 0.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1264) TMEM240 PF15207.6 EXF83667.1 - 0.021 14.5 0.0 0.037 13.7 0.0 1.3 1 0 0 1 1 1 0 TMEM240 family Fungal_trans PF04082.18 EXF83669.1 - 5.8e-15 55.0 2.7 6.2e-15 54.9 0.6 1.9 2 0 0 2 2 2 1 Fungal specific transcription factor domain CN_hydrolase PF00795.22 EXF83670.1 - 1.2e-44 152.7 0.1 2.1e-44 151.9 0.1 1.4 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase FAD_binding_4 PF01565.23 EXF83672.1 - 3.4e-24 85.2 0.1 6e-24 84.4 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain FAD-oxidase_C PF02913.19 EXF83672.1 - 1.3e-11 44.6 0.0 1.9e-11 44.1 0.0 1.2 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain Trp_DMAT PF11991.8 EXF83673.1 - 1.4e-101 340.6 0.0 1.6e-101 340.3 0.0 1.0 1 0 0 1 1 1 1 Tryptophan dimethylallyltransferase DUF4937 PF16291.5 EXF83674.1 - 0.0035 17.5 0.5 0.1 12.8 0.1 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4937 ABM PF03992.16 EXF83674.1 - 0.09 12.9 0.1 0.84 9.8 0.0 2.1 2 0 0 2 2 2 0 Antibiotic biosynthesis monooxygenase NmrA PF05368.13 EXF83675.1 - 2e-15 57.0 0.4 6.4e-15 55.3 0.4 1.7 1 1 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EXF83675.1 - 5.4e-15 55.8 0.0 9.2e-15 55.0 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EXF83675.1 - 0.00063 19.3 0.0 0.0012 18.3 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family DapB_N PF01113.20 EXF83675.1 - 0.0049 17.0 0.1 0.016 15.3 0.1 1.9 2 0 0 2 2 2 1 Dihydrodipicolinate reductase, N-terminus TraT PF05818.12 EXF83675.1 - 0.061 13.0 0.0 0.097 12.4 0.0 1.3 1 0 0 1 1 1 0 Enterobacterial TraT complement resistance protein Semialdhyde_dh PF01118.24 EXF83675.1 - 0.087 13.3 0.3 0.48 10.9 0.1 2.2 2 1 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain DUF924 PF06041.11 EXF83677.1 - 1.5e-56 191.4 0.5 2e-56 191.0 0.5 1.2 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF924) Glyco_hydro_11 PF00457.17 EXF83678.1 - 2.7e-75 251.9 16.7 3.2e-75 251.7 16.7 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 11 Cu_amine_oxid PF01179.20 EXF83679.1 - 8.7e-166 551.9 0.0 1.2e-165 551.4 0.0 1.2 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN3 PF02728.16 EXF83679.1 - 1.7e-06 28.3 0.0 3.6e-06 27.3 0.0 1.5 1 0 0 1 1 1 1 Copper amine oxidase, N3 domain Cu_amine_oxidN2 PF02727.16 EXF83679.1 - 6.2e-06 26.4 0.0 1.6e-05 25.0 0.0 1.8 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain AA_permease_2 PF13520.6 EXF83680.1 - 7.5e-65 219.4 38.2 9.1e-65 219.1 38.2 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EXF83680.1 - 1.3e-22 80.1 35.1 1.8e-22 79.6 35.1 1.1 1 0 0 1 1 1 1 Amino acid permease Nucleos_tra2_N PF01773.20 EXF83680.1 - 2 9.1 7.5 0.3 11.7 0.2 3.3 4 0 0 4 4 4 0 Na+ dependent nucleoside transporter N-terminus Fungal_trans PF04082.18 EXF83681.1 - 3.7e-09 36.0 0.0 7.3e-09 35.0 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF83681.1 - 1.5e-06 28.2 7.5 1.5e-06 28.2 7.5 1.7 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Med30 PF11315.8 EXF83681.1 - 4.3 7.5 6.1 0.65 10.2 0.2 2.4 2 0 0 2 2 2 0 Mediator complex subunit 30 DEAD PF00270.29 EXF83682.1 - 5.6e-47 159.8 0.0 4.4e-44 150.3 0.0 2.2 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.31 EXF83682.1 - 4.3e-21 75.3 0.0 6.2e-19 68.4 0.0 2.8 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EXF83682.1 - 2.7e-08 34.0 0.0 4.2e-08 33.4 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_RecD PF05127.14 EXF83682.1 - 0.0042 17.0 0.0 0.0075 16.1 0.0 1.4 1 0 0 1 1 1 1 Helicase AAA_22 PF13401.6 EXF83682.1 - 0.074 13.3 0.9 0.88 9.8 1.3 2.5 2 2 0 2 2 2 0 AAA domain AAA_30 PF13604.6 EXF83682.1 - 0.076 12.7 0.0 0.27 10.9 0.0 1.9 2 0 0 2 2 2 0 AAA domain DUF2075 PF09848.9 EXF83682.1 - 0.12 11.6 0.1 0.3 10.3 0.1 1.6 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Fungal_trans PF04082.18 EXF83683.1 - 2.9e-08 33.1 0.6 5.9e-08 32.1 0.6 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF83683.1 - 6.1e-08 32.7 11.5 9.7e-08 32.0 11.5 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SUIM_assoc PF16619.5 EXF83683.1 - 7.4 6.7 35.6 0.015 15.4 4.2 5.0 5 0 0 5 5 5 0 Unstructured region C-term to UIM in Ataxin3 PRKCSH PF07915.13 EXF83684.1 - 9.6e-20 71.4 0.3 9.6e-20 71.4 0.3 2.2 2 0 0 2 2 2 1 Glucosidase II beta subunit-like protein PRKCSH_1 PF13015.6 EXF83684.1 - 0.017 14.8 0.0 1.5 8.5 0.0 2.3 2 0 0 2 2 2 0 Glucosidase II beta subunit-like protein Pkinase PF00069.25 EXF83686.1 - 2.6e-18 66.3 0.0 4.8e-18 65.5 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF83686.1 - 0.0013 18.1 0.0 0.0022 17.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase VWA PF00092.28 EXF83686.1 - 0.047 13.9 0.0 0.097 12.9 0.0 1.6 1 0 0 1 1 1 0 von Willebrand factor type A domain PIRT PF15099.6 EXF83687.1 - 0.004 16.7 0.2 0.0067 16.0 0.2 1.3 1 0 0 1 1 1 1 Phosphoinositide-interacting protein family Abhydrolase_1 PF00561.20 EXF83688.1 - 5.9e-11 42.5 2.0 5.4e-09 36.1 1.3 2.5 2 1 0 3 3 3 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EXF83688.1 - 1.3e-10 42.3 0.0 2.1e-10 41.6 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EXF83688.1 - 9.9e-09 34.8 0.1 1.5e-08 34.2 0.1 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 EXF83688.1 - 0.021 14.9 0.0 0.034 14.3 0.0 1.5 1 1 0 1 1 1 0 Thioesterase domain ABC_tran PF00005.27 EXF83689.1 - 8.7e-42 142.9 0.0 1e-23 84.4 0.0 2.4 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EXF83689.1 - 1.2e-37 130.1 31.7 7e-21 75.1 8.5 3.9 4 0 0 4 4 4 3 ABC transporter transmembrane region SMC_N PF02463.19 EXF83689.1 - 1.7e-13 50.5 1.1 1.4e-05 24.6 0.0 4.1 3 1 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EXF83689.1 - 7.6e-08 33.1 0.0 2.9e-05 24.7 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_21 PF13304.6 EXF83689.1 - 3e-07 30.5 0.3 0.011 15.5 0.0 4.3 3 1 1 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EXF83689.1 - 3.5e-06 26.7 0.4 0.12 12.2 0.3 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 EXF83689.1 - 5.7e-06 26.8 0.2 0.11 12.8 0.0 2.9 2 0 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 EXF83689.1 - 5.9e-06 26.6 0.1 0.042 14.1 0.0 3.1 3 0 0 3 3 2 2 AAA domain RsgA_GTPase PF03193.16 EXF83689.1 - 0.00011 22.2 0.0 0.53 10.2 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase NACHT PF05729.12 EXF83689.1 - 0.0011 18.9 1.5 0.76 9.7 0.2 2.8 2 0 0 2 2 2 2 NACHT domain T2SSE PF00437.20 EXF83689.1 - 0.0014 17.7 0.0 1.5 7.8 0.0 2.4 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_25 PF13481.6 EXF83689.1 - 0.0016 18.1 0.6 0.047 13.3 0.2 2.6 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 EXF83689.1 - 0.0022 18.1 0.0 1.2 9.2 0.0 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase DUF87 PF01935.17 EXF83689.1 - 0.0027 17.8 3.6 0.019 15.1 0.7 2.5 2 0 0 2 2 2 1 Helicase HerA, central domain cobW PF02492.19 EXF83689.1 - 0.0049 16.5 0.3 0.16 11.6 0.1 2.4 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA PF00004.29 EXF83689.1 - 0.0051 17.2 0.4 11 6.5 0.0 3.5 3 1 0 3 3 2 0 ATPase family associated with various cellular activities (AAA) SbcCD_C PF13558.6 EXF83689.1 - 0.024 14.9 0.0 1.3 9.3 0.0 2.9 2 0 0 2 2 2 0 Putative exonuclease SbcCD, C subunit ATPase_2 PF01637.18 EXF83689.1 - 0.031 14.2 0.0 0.23 11.4 0.0 2.2 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_30 PF13604.6 EXF83689.1 - 0.036 13.8 0.6 4.5 7.0 0.0 2.9 2 1 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 EXF83689.1 - 0.058 12.7 0.2 3.8 6.7 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin FtsK_SpoIIIE PF01580.18 EXF83689.1 - 0.075 12.4 0.5 3 7.1 0.1 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family TsaE PF02367.17 EXF83689.1 - 0.078 13.0 0.1 1.2 9.1 0.0 2.5 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE TrwB_AAD_bind PF10412.9 EXF83689.1 - 0.08 11.8 0.1 3.7 6.3 0.0 2.2 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain IstB_IS21 PF01695.17 EXF83689.1 - 0.094 12.4 0.3 2.8 7.6 0.0 3.0 3 0 0 3 3 3 0 IstB-like ATP binding protein Pox_A32 PF04665.12 EXF83689.1 - 0.12 11.8 0.0 15 4.9 0.0 2.3 2 0 0 2 2 2 0 Poxvirus A32 protein Dynamin_N PF00350.23 EXF83689.1 - 0.13 12.3 0.4 7.5 6.6 0.0 2.4 2 0 0 2 2 2 0 Dynamin family DUF2075 PF09848.9 EXF83689.1 - 0.22 10.7 1.7 6.9 5.8 0.1 2.4 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) p450 PF00067.22 EXF83690.1 - 6.8e-53 180.0 0.0 8.9e-53 179.7 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 CBM_1 PF00734.18 EXF83691.1 - 7.5e-12 45.0 9.5 2.6e-11 43.3 9.5 2.0 1 0 0 1 1 1 1 Fungal cellulose binding domain Nucleos_tra2_C PF07662.13 EXF83692.1 - 5.3e-69 232.2 1.9 5.3e-69 232.2 1.9 2.3 3 0 0 3 3 3 1 Na+ dependent nucleoside transporter C-terminus Nucleos_tra2_N PF01773.20 EXF83692.1 - 9.7e-25 87.0 1.0 9.7e-25 87.0 1.0 2.7 3 0 0 3 3 3 1 Na+ dependent nucleoside transporter N-terminus Gate PF07670.14 EXF83692.1 - 0.045 14.0 14.6 0.09 13.0 8.1 3.4 2 1 0 2 2 2 0 Nucleoside recognition COX2-transmemb PF09125.10 EXF83692.1 - 0.27 11.0 1.8 5.6 6.8 0.3 3.0 2 0 0 2 2 2 0 Cytochrome C oxidase subunit II, transmembrane Sugar_tr PF00083.24 EXF83693.1 - 8e-70 235.9 28.3 9.3e-70 235.7 28.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF83693.1 - 4.5e-21 75.2 35.9 3.3e-20 72.3 33.3 2.7 2 1 1 3 3 3 1 Major Facilitator Superfamily MFS_2 PF13347.6 EXF83693.1 - 2.5e-05 23.1 1.8 2.5e-05 23.1 1.8 4.0 4 1 1 5 5 5 3 MFS/sugar transport protein Bac_rhamnosid6H PF17389.2 EXF83694.1 - 2e-16 60.2 0.0 5.9e-10 38.9 0.0 2.1 2 0 0 2 2 2 2 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain Glyco_hydro_28 PF00295.17 EXF83695.1 - 9.5e-29 100.5 14.1 1.3e-28 100.1 12.2 1.8 1 1 1 2 2 2 2 Glycosyl hydrolases family 28 SHR-BD PF06650.12 EXF83697.1 - 5.9e-97 324.3 0.0 5.6e-95 317.8 0.0 3.2 3 0 0 3 3 3 1 SHR-binding domain of vacuolar-sorting associated protein 13 VPS13_mid_rpt PF16910.5 EXF83697.1 - 4e-91 304.6 1.7 1.8e-90 302.5 1.8 5.8 8 1 1 9 9 9 2 Repeating coiled region of VPS13 VPS13 PF16908.5 EXF83697.1 - 1.1e-86 290.5 0.7 1.3e-82 277.2 0.0 4.1 4 0 0 4 4 4 2 Vacuolar sorting-associated protein 13, N-terminal VPS13_C PF16909.5 EXF83697.1 - 2.5e-75 252.2 6.8 1.6e-70 236.5 0.5 2.9 2 0 0 2 2 2 2 Vacuolar-sorting-associated 13 protein C-terminal Chorein_N PF12624.7 EXF83697.1 - 5.1e-40 136.2 1.0 1.8e-39 134.5 0.0 2.6 2 0 0 2 2 2 1 N-terminal region of Chorein or VPS13 ATG_C PF09333.11 EXF83697.1 - 1.7e-08 34.7 0.0 1.4e-07 31.7 0.0 2.6 2 0 0 2 2 2 1 Autophagy-related protein C terminal domain DUF3429 PF11911.8 EXF83698.1 - 2e-45 154.6 7.9 3.5e-45 153.8 7.9 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3429) XPG_I PF00867.18 EXF83699.1 - 0.1 13.0 0.0 0.13 12.6 0.0 1.3 1 1 0 1 1 1 0 XPG I-region SelP_N PF04592.14 EXF83699.1 - 3.2 7.1 12.5 3.7 6.9 12.5 1.1 1 0 0 1 1 1 0 Selenoprotein P, N terminal region TauD PF02668.16 EXF83702.1 - 7e-53 180.1 0.4 8e-53 179.9 0.4 1.0 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Sld5 PF05916.11 EXF83703.1 - 1.8e-18 67.0 0.0 3e-18 66.3 0.0 1.3 1 0 0 1 1 1 1 GINS complex protein Sod_Fe_C PF02777.18 EXF83704.1 - 1.1e-38 131.5 0.1 2.2e-38 130.5 0.1 1.5 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 EXF83704.1 - 5.2e-30 103.8 1.6 8.9e-30 103.0 1.6 1.4 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain HET PF06985.11 EXF83706.1 - 2.3e-25 89.6 0.0 3.8e-25 88.9 0.0 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) bZIP_1 PF00170.21 EXF83708.1 - 2.7e-09 37.0 8.5 4.3e-09 36.3 8.5 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_Maf PF03131.17 EXF83708.1 - 0.011 16.2 4.7 0.021 15.3 4.7 1.4 1 0 0 1 1 1 0 bZIP Maf transcription factor bZIP_2 PF07716.15 EXF83708.1 - 0.083 13.0 12.5 0.39 10.8 12.5 2.1 1 1 0 1 1 1 0 Basic region leucine zipper FAD_binding_4 PF01565.23 EXF83709.1 - 5.8e-31 107.1 0.1 1.2e-30 106.1 0.1 1.5 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EXF83709.1 - 1.1e-05 25.4 0.0 2.7e-05 24.2 0.0 1.6 1 0 0 1 1 1 1 Berberine and berberine like Fungal_trans_2 PF11951.8 EXF83710.1 - 6.6e-08 31.8 1.1 1e-05 24.5 0.1 2.2 2 0 0 2 2 2 2 Fungal specific transcription factor domain adh_short PF00106.25 EXF83711.1 - 5.1e-19 68.5 0.0 1.6e-14 53.8 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EXF83711.1 - 5.9e-08 32.6 0.0 5.8e-06 26.0 0.0 2.1 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF83711.1 - 4.9e-06 26.6 0.0 8.5e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 KR domain OPT PF03169.15 EXF83712.1 - 1.6e-178 595.2 52.8 1.8e-178 595.0 52.8 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein AA_permease PF00324.21 EXF83716.1 - 8.1e-144 479.8 38.4 1e-143 479.4 38.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EXF83716.1 - 5.9e-40 137.4 40.7 7.7e-40 137.0 40.7 1.1 1 0 0 1 1 1 1 Amino acid permease zf-C2H2_4 PF13894.6 EXF83717.1 - 0.022 15.6 0.2 0.067 14.1 0.2 1.9 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2 PF00096.26 EXF83717.1 - 0.031 14.7 0.1 0.075 13.5 0.1 1.7 1 0 0 1 1 1 0 Zinc finger, C2H2 type Nefa_Nip30_N PF10187.9 EXF83717.1 - 0.083 13.2 0.4 0.083 13.2 0.4 2.7 2 0 0 2 2 2 0 N-terminal domain of NEFA-interacting nuclear protein NIP30 adh_short PF00106.25 EXF83718.1 - 4.5e-20 71.9 0.0 1.3e-17 63.9 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EXF83718.1 - 1.7e-09 37.6 0.0 1.7e-08 34.3 0.0 1.9 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF83718.1 - 4.6e-06 26.7 0.0 8.8e-06 25.7 0.0 1.4 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EXF83718.1 - 0.00032 20.2 0.0 0.00055 19.5 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EXF83718.1 - 0.0059 15.8 0.0 0.0089 15.2 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 EXF83718.1 - 0.023 14.1 0.0 0.034 13.6 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 EXF83718.1 - 0.028 13.6 0.1 0.051 12.7 0.0 1.5 2 0 0 2 2 2 0 Male sterility protein Shikimate_DH PF01488.20 EXF83718.1 - 0.19 11.8 0.0 0.3 11.2 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase DUF3425 PF11905.8 EXF83719.1 - 1.5e-17 63.8 0.0 3e-17 62.8 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) bZIP_1 PF00170.21 EXF83719.1 - 0.052 13.7 4.3 0.11 12.6 4.3 1.5 1 0 0 1 1 1 0 bZIP transcription factor NmrA PF05368.13 EXF83720.1 - 4.7e-22 78.7 0.0 5.9e-22 78.4 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EXF83720.1 - 4.6e-07 29.9 0.0 6.6e-07 29.4 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EXF83720.1 - 0.00011 21.8 0.1 0.00061 19.3 0.0 1.9 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family KR PF08659.10 EXF83720.1 - 0.12 12.3 0.0 0.19 11.6 0.0 1.3 1 0 0 1 1 1 0 KR domain Methyltransf_2 PF00891.18 EXF83721.1 - 8.1e-16 57.9 0.0 1.6e-15 56.9 0.0 1.5 1 1 0 1 1 1 1 O-methyltransferase domain Arginase PF00491.21 EXF83722.1 - 1.3e-23 83.9 0.0 1.5e-23 83.7 0.0 1.0 1 0 0 1 1 1 1 Arginase family Condensation PF00668.20 EXF83723.1 - 6.5e-86 288.8 0.0 1.9e-33 115.8 0.0 3.8 3 1 0 3 3 3 3 Condensation domain AMP-binding PF00501.28 EXF83723.1 - 5.4e-33 114.2 0.0 1.1e-32 113.2 0.0 1.5 1 0 0 1 1 1 1 AMP-binding enzyme PP-binding PF00550.25 EXF83723.1 - 5.5e-17 61.9 0.1 2.1e-05 24.8 0.0 4.9 4 0 0 4 4 4 3 Phosphopantetheine attachment site AMP-binding_C PF13193.6 EXF83723.1 - 0.055 14.5 0.0 2 9.5 0.0 3.0 3 0 0 3 3 3 0 AMP-binding enzyme C-terminal domain Abhydrolase_3 PF07859.13 EXF83724.1 - 1.1e-28 100.5 0.0 2.4e-28 99.4 0.0 1.6 1 1 1 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 EXF83724.1 - 0.012 15.4 0.0 0.019 14.8 0.0 1.2 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase Say1_Mug180 PF10340.9 EXF83724.1 - 0.024 13.5 0.0 0.19 10.5 0.0 1.9 2 0 0 2 2 2 0 Steryl acetyl hydrolase COesterase PF00135.28 EXF83724.1 - 0.036 12.9 0.0 0.053 12.4 0.0 1.2 1 0 0 1 1 1 0 Carboxylesterase family SAPS PF04499.15 EXF83725.1 - 1.8e-161 538.3 0.3 2.7e-159 531.1 0.0 3.0 2 1 0 2 2 2 2 SIT4 phosphatase-associated protein Sugar_tr PF00083.24 EXF83726.1 - 1.2e-115 387.0 25.7 1.4e-115 386.8 25.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF83726.1 - 1.6e-20 73.3 55.0 2.3e-17 63.0 27.8 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Fungal_trans PF04082.18 EXF83727.1 - 2.9e-07 29.8 0.2 3.9e-07 29.4 0.2 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain ABC_tran PF00005.27 EXF83728.1 - 1.6e-43 148.5 0.0 1.3e-26 93.8 0.0 2.5 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EXF83728.1 - 3.8e-26 92.4 2.9 3.8e-26 92.4 2.9 2.9 2 1 0 2 2 1 1 ABC transporter transmembrane region Amdase PF17645.1 EXF83728.1 - 8.3e-15 55.0 0.1 2.7e-14 53.3 0.0 1.9 2 0 0 2 2 1 1 Arylmalonate decarboxylase SMC_N PF02463.19 EXF83728.1 - 1.4e-12 47.5 2.2 0.023 14.2 0.0 4.2 4 0 0 4 4 4 3 RecF/RecN/SMC N terminal domain AAA PF00004.29 EXF83728.1 - 4.9e-07 30.2 0.0 0.11 12.9 0.0 3.6 2 2 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_21 PF13304.6 EXF83728.1 - 5.6e-07 29.7 0.5 0.037 13.8 0.0 4.3 3 1 1 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 EXF83728.1 - 1e-06 29.1 0.4 0.045 14.0 0.0 3.2 2 2 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 EXF83728.1 - 4.1e-06 26.8 0.5 0.052 13.5 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase T2SSE PF00437.20 EXF83728.1 - 2.8e-05 23.3 0.2 0.019 14.1 0.0 2.5 2 0 0 2 2 2 2 Type II/IV secretion system protein IstB_IS21 PF01695.17 EXF83728.1 - 7e-05 22.6 1.4 1.9 8.2 0.0 3.7 3 0 0 3 3 3 1 IstB-like ATP binding protein AAA_16 PF13191.6 EXF83728.1 - 8e-05 23.1 0.0 0.6 10.5 0.0 3.1 2 0 0 2 2 2 2 AAA ATPase domain AAA_7 PF12775.7 EXF83728.1 - 8.1e-05 22.2 0.4 0.48 9.9 0.0 2.5 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_33 PF13671.6 EXF83728.1 - 0.00055 20.1 1.6 0.96 9.6 0.0 3.3 3 0 0 3 3 3 2 AAA domain SbcCD_C PF13558.6 EXF83728.1 - 0.0011 19.2 0.1 2.2 8.6 0.0 2.9 2 0 0 2 2 2 1 Putative exonuclease SbcCD, C subunit Roc PF08477.13 EXF83728.1 - 0.0014 18.9 0.1 3.2 8.0 0.0 2.8 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.6 EXF83728.1 - 0.0022 17.7 3.5 1.3 8.8 0.0 3.0 3 0 0 3 3 2 2 P-loop containing region of AAA domain RNA_helicase PF00910.22 EXF83728.1 - 0.0025 18.2 0.2 5.2 7.5 0.0 3.2 3 0 0 3 3 3 0 RNA helicase Dynamin_N PF00350.23 EXF83728.1 - 0.0043 17.1 3.9 0.11 12.6 0.1 3.0 3 0 0 3 3 3 1 Dynamin family Septin PF00735.18 EXF83728.1 - 0.0046 16.3 0.1 3.7 6.7 0.0 2.6 2 0 0 2 2 2 1 Septin NB-ARC PF00931.22 EXF83728.1 - 0.0076 15.5 1.8 0.11 11.6 0.3 3.0 2 1 0 2 2 2 1 NB-ARC domain AAA_23 PF13476.6 EXF83728.1 - 0.009 16.5 0.2 1.5 9.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 EXF83728.1 - 0.0095 15.7 0.1 0.089 12.5 0.0 2.3 2 0 0 2 2 2 1 AAA domain AIG1 PF04548.16 EXF83728.1 - 0.013 14.9 0.0 0.033 13.5 0.0 1.7 1 0 0 1 1 1 0 AIG1 family AAA_5 PF07728.14 EXF83728.1 - 0.013 15.5 0.2 7.4 6.6 0.0 3.2 3 1 0 3 3 2 0 AAA domain (dynein-related subfamily) DEAD PF00270.29 EXF83728.1 - 0.016 15.0 3.2 2.5 7.8 0.1 2.9 3 0 0 3 3 2 0 DEAD/DEAH box helicase MMR_HSR1 PF01926.23 EXF83728.1 - 0.017 15.2 0.0 0.84 9.7 0.0 2.8 2 0 0 2 2 2 0 50S ribosome-binding GTPase TsaE PF02367.17 EXF83728.1 - 0.026 14.5 0.1 3.7 7.6 0.0 2.6 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE PRK PF00485.18 EXF83728.1 - 0.038 13.7 1.4 0.14 11.8 0.0 2.2 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family ATPase_2 PF01637.18 EXF83728.1 - 0.043 13.7 0.1 4 7.3 0.1 2.4 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea Pox_A32 PF04665.12 EXF83728.1 - 0.045 13.2 0.1 0.14 11.6 0.1 1.8 1 0 0 1 1 1 0 Poxvirus A32 protein Rad17 PF03215.15 EXF83728.1 - 0.047 13.6 2.0 6.5 6.6 0.1 3.3 3 0 0 3 3 3 0 Rad17 P-loop domain NACHT PF05729.12 EXF83728.1 - 0.049 13.5 0.7 11 5.9 0.1 2.7 2 0 0 2 2 2 0 NACHT domain cobW PF02492.19 EXF83728.1 - 0.072 12.7 0.8 13 5.3 0.0 2.6 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_11 PF13086.6 EXF83728.1 - 0.094 12.5 0.3 2.2 8.0 0.0 2.6 3 0 0 3 3 2 0 AAA domain AAA_15 PF13175.6 EXF83728.1 - 0.11 12.2 0.1 4.1 7.0 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain AAA_18 PF13238.6 EXF83728.1 - 0.12 12.9 0.3 4.3 7.9 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_PrkA PF08298.11 EXF83728.1 - 0.15 11.0 0.5 0.87 8.4 0.1 2.1 2 0 0 2 2 2 0 PrkA AAA domain AAA_25 PF13481.6 EXF83728.1 - 0.21 11.1 1.2 4.9 6.7 0.1 2.8 3 0 0 3 3 2 0 AAA domain PduV-EutP PF10662.9 EXF83728.1 - 0.33 10.7 1.1 5.7 6.7 0.1 2.7 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation NTPase_1 PF03266.15 EXF83728.1 - 0.63 9.9 5.6 1 9.3 0.0 3.5 4 0 0 4 4 4 0 NTPase ATP_bind_1 PF03029.17 EXF83728.1 - 0.9 9.3 4.9 0.71 9.6 0.1 2.6 3 0 0 3 3 2 0 Conserved hypothetical ATP binding protein CDC27 PF09507.10 EXF83729.1 - 0.67 9.3 16.4 0.88 8.9 16.4 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 YjeF_N PF03853.15 EXF83732.1 - 5.2e-32 111.1 0.0 6.3e-32 110.8 0.0 1.1 1 0 0 1 1 1 1 YjeF-related protein N-terminus DJ-1_PfpI PF01965.24 EXF83733.1 - 3e-11 43.4 0.0 3.7e-11 43.1 0.0 1.1 1 0 0 1 1 1 1 DJ-1/PfpI family VipB PF05943.12 EXF83733.1 - 0.16 10.7 0.0 0.21 10.3 0.0 1.1 1 0 0 1 1 1 0 Type VI secretion protein, EvpB/VC_A0108, tail sheath DASH_Spc19 PF08287.11 EXF83734.1 - 4.2e-50 169.7 0.0 5.8e-50 169.2 0.0 1.2 1 0 0 1 1 1 1 Spc19 SlyX PF04102.12 EXF83734.1 - 0.011 16.3 1.2 0.073 13.7 0.2 2.6 3 0 0 3 3 3 0 SlyX Lzipper-MIP1 PF14389.6 EXF83734.1 - 0.66 10.3 6.3 2.2 8.6 3.0 2.5 2 1 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 SH3_1 PF00018.28 EXF83735.1 - 1.3e-09 37.5 0.2 5.3e-09 35.5 0.1 2.0 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 EXF83735.1 - 6.1e-07 29.2 0.0 1.2e-06 28.2 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EXF83735.1 - 1.1e-05 25.0 0.0 2.2e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain MARVEL PF01284.23 EXF83735.1 - 0.19 11.7 13.7 0.29 11.1 13.7 1.2 1 0 0 1 1 1 0 Membrane-associating domain DUF2417 PF10329.9 EXF83735.1 - 0.7 9.3 10.4 1.1 8.6 10.4 1.3 1 0 0 1 1 1 0 Region of unknown function (DUF2417) MpPF26 PF07666.11 EXF83735.1 - 7.6 6.7 7.8 2.1 8.5 1.3 2.1 1 1 1 2 2 2 0 M penetrans paralogue family 26 Mito_fiss_reg PF05308.11 EXF83736.1 - 1 9.4 5.0 2.3 8.2 5.0 1.5 1 0 0 1 1 1 0 Mitochondrial fission regulator CAP_N PF01213.19 EXF83736.1 - 4.2 6.8 5.5 7 6.0 5.5 1.4 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Dynactin_p22 PF07426.11 EXF83737.1 - 2.4e-10 40.5 0.0 5.3e-10 39.4 0.0 1.5 1 1 1 2 2 2 1 Dynactin subunit p22 VIR_N PF15912.5 EXF83737.1 - 0.12 12.0 0.0 0.14 11.8 0.0 1.2 1 0 0 1 1 1 0 Virilizer, N-terminal Aa_trans PF01490.18 EXF83738.1 - 2.8e-91 306.3 18.2 2.8e-91 306.3 18.2 1.3 2 0 0 2 2 2 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 EXF83738.1 - 0.00012 21.3 22.9 0.00024 20.3 22.9 1.5 1 0 0 1 1 1 1 Tryptophan/tyrosine permease family Ribosomal_S16 PF00886.19 EXF83739.1 - 1e-24 86.4 0.1 1.8e-24 85.5 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein S16 Methyltransf_23 PF13489.6 EXF83740.1 - 2.5e-25 89.2 0.0 4e-25 88.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF83740.1 - 5.9e-11 42.9 0.0 1.8e-10 41.3 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF83740.1 - 7.1e-11 42.1 0.0 7.4e-10 38.8 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF83740.1 - 4.3e-09 36.9 0.0 1.2e-08 35.4 0.0 1.8 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF83740.1 - 3.7e-07 30.8 0.0 3.3e-06 27.8 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain CheR PF01739.18 EXF83740.1 - 0.0014 18.1 0.0 0.0027 17.2 0.0 1.4 1 0 0 1 1 1 1 CheR methyltransferase, SAM binding domain FtsJ PF01728.19 EXF83740.1 - 0.0017 18.5 0.0 0.0034 17.5 0.0 1.4 1 0 0 1 1 1 1 FtsJ-like methyltransferase PrmA PF06325.13 EXF83740.1 - 0.004 16.6 0.0 0.0064 15.9 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 EXF83740.1 - 0.007 15.9 0.0 0.029 13.9 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_16 PF10294.9 EXF83740.1 - 0.031 14.0 0.0 0.058 13.1 0.0 1.4 1 0 0 1 1 1 0 Lysine methyltransferase Ubie_methyltran PF01209.18 EXF83740.1 - 0.04 13.2 0.0 17 4.6 0.0 2.9 2 1 1 3 3 3 0 ubiE/COQ5 methyltransferase family GPI-anchored PF10342.9 EXF83741.1 - 1.3e-14 54.7 0.6 1.3e-14 54.7 0.6 2.5 2 1 1 3 3 3 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family DUF4369 PF14289.6 EXF83741.1 - 0.0028 18.1 1.4 0.0094 16.4 1.4 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF4369) SOG2 PF10428.9 EXF83741.1 - 2.9 7.0 17.6 3.1 6.9 17.6 1.0 1 0 0 1 1 1 0 RAM signalling pathway protein SH3_9 PF14604.6 EXF83742.1 - 3.5e-06 26.8 3.6 0.00085 19.1 0.2 2.5 2 0 0 2 2 2 2 Variant SH3 domain SH3_2 PF07653.17 EXF83742.1 - 8.6e-05 22.1 3.5 0.0021 17.7 0.2 2.5 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.28 EXF83742.1 - 0.43 10.2 5.8 0.095 12.3 0.8 2.3 2 0 0 2 2 2 0 SH3 domain MFS_1 PF07690.16 EXF83743.1 - 1.1e-38 133.1 34.5 1.1e-38 133.1 34.5 1.8 1 1 0 1 1 1 1 Major Facilitator Superfamily OATP PF03137.20 EXF83743.1 - 0.025 12.9 2.5 0.025 12.9 0.7 1.9 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family NmrA PF05368.13 EXF83744.1 - 3.6e-23 82.3 0.0 4.7e-23 82.0 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EXF83744.1 - 4.8e-09 36.4 0.0 1.1e-08 35.2 0.0 1.6 1 1 0 1 1 1 1 NAD(P)H-binding DapB_N PF01113.20 EXF83744.1 - 1.4e-05 25.2 0.1 3e-05 24.1 0.1 1.6 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Semialdhyde_dh PF01118.24 EXF83744.1 - 2.5e-05 24.7 0.0 4.4e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Sacchrp_dh_NADP PF03435.18 EXF83744.1 - 0.00041 20.6 0.2 0.0011 19.2 0.1 1.7 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_4 PF07993.12 EXF83744.1 - 0.023 13.9 0.0 0.032 13.4 0.0 1.2 1 0 0 1 1 1 0 Male sterility protein DXP_reductoisom PF02670.16 EXF83744.1 - 0.062 14.0 0.0 0.13 13.0 0.0 1.6 1 0 0 1 1 1 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase Epimerase PF01370.21 EXF83744.1 - 0.078 12.4 0.0 0.18 11.3 0.0 1.7 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Glyco_hydro_11 PF00457.17 EXF83745.1 - 4.3e-60 202.4 11.1 5.1e-60 202.1 11.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 11 Epimerase PF01370.21 EXF83746.1 - 1.8e-11 44.0 0.0 2.8e-11 43.4 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EXF83746.1 - 3.1e-06 27.2 0.0 5.4e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EXF83746.1 - 0.019 14.5 0.2 4.9 6.6 0.4 2.5 2 1 0 2 2 2 0 NmrA-like family UBA_2 PF08587.11 EXF83746.1 - 0.16 12.1 0.0 0.38 10.9 0.0 1.6 1 0 0 1 1 1 0 Ubiquitin associated domain (UBA) MFS_1 PF07690.16 EXF83747.1 - 1.2e-36 126.4 30.9 1.2e-36 126.4 30.9 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily COX14 PF14880.6 EXF83747.1 - 0.28 11.1 5.9 0.37 10.7 0.0 3.2 2 1 1 3 3 3 0 Cytochrome oxidase c assembly Aldedh PF00171.22 EXF83748.1 - 1.9e-75 254.2 0.0 2.2e-75 254.0 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family FAD_binding_3 PF01494.19 EXF83749.1 - 4.4e-51 174.2 0.0 6.1e-51 173.7 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain GST_N_4 PF17172.4 EXF83749.1 - 4e-21 75.6 0.0 9.9e-21 74.3 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain FAD_binding_2 PF00890.24 EXF83749.1 - 4.5e-09 35.9 0.1 1.2e-05 24.6 0.2 2.2 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.24 EXF83749.1 - 2.5e-07 30.6 1.2 4.8e-06 26.4 0.1 2.5 2 1 0 2 2 2 1 FAD dependent oxidoreductase GST_C_6 PF17171.4 EXF83749.1 - 3.6e-06 26.7 0.0 7.6e-06 25.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Pyr_redox_2 PF07992.14 EXF83749.1 - 1.3e-05 24.6 0.0 8.9e-05 21.9 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EXF83749.1 - 1.5e-05 25.4 0.5 0.0095 16.5 0.1 2.7 3 0 0 3 3 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EXF83749.1 - 2.4e-05 23.9 0.3 0.00011 21.7 0.3 1.9 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EXF83749.1 - 3.5e-05 23.9 0.1 0.0001 22.4 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 EXF83749.1 - 4.9e-05 22.2 0.1 7.5e-05 21.6 0.1 1.2 1 0 0 1 1 1 1 HI0933-like protein Tom37 PF10568.9 EXF83749.1 - 0.00021 21.6 0.0 0.0004 20.7 0.0 1.5 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein Thi4 PF01946.17 EXF83749.1 - 0.00096 18.5 0.1 0.0021 17.3 0.1 1.5 1 0 0 1 1 1 1 Thi4 family GIDA PF01134.22 EXF83749.1 - 0.0012 18.1 0.1 0.0018 17.4 0.1 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A ApbA PF02558.16 EXF83749.1 - 0.0015 18.2 0.1 0.003 17.2 0.1 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Pyr_redox_3 PF13738.6 EXF83749.1 - 0.0034 16.7 0.0 0.0064 15.8 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EXF83749.1 - 0.004 16.3 0.2 0.0061 15.7 0.2 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein GST_C_2 PF13410.6 EXF83749.1 - 0.0074 16.3 0.0 0.019 15.0 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain NAD_binding_7 PF13241.6 EXF83749.1 - 0.01 16.2 0.0 0.022 15.2 0.0 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding UDPG_MGDP_dh_N PF03721.14 EXF83749.1 - 0.023 14.3 0.1 0.042 13.4 0.1 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Trp_halogenase PF04820.14 EXF83749.1 - 0.055 12.3 0.1 0.097 11.5 0.1 1.4 1 0 0 1 1 1 0 Tryptophan halogenase GST_N_3 PF13417.6 EXF83749.1 - 0.065 13.7 0.0 0.17 12.3 0.0 1.7 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain 3HCDH_N PF02737.18 EXF83749.1 - 0.12 12.2 0.1 0.25 11.2 0.1 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ThiF PF00899.21 EXF83749.1 - 0.17 11.2 0.1 0.3 10.4 0.1 1.3 1 0 0 1 1 1 0 ThiF family Beta-lactamase PF00144.24 EXF83750.1 - 1.1e-18 67.6 0.1 1.6e-18 67.0 0.1 1.1 1 0 0 1 1 1 1 Beta-lactamase Med3 PF11593.8 EXF83751.1 - 0.12 11.6 4.5 0.18 11.0 4.5 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal TP_methylase PF00590.20 EXF83753.1 - 7.9e-46 156.7 0.2 1.4e-45 155.8 0.2 1.5 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases NAD_binding_7 PF13241.6 EXF83753.1 - 4.4e-14 52.8 0.0 9e-14 51.8 0.0 1.5 1 0 0 1 1 1 1 Putative NAD(P)-binding Sirohm_synth_C PF14823.6 EXF83753.1 - 4.5e-11 42.2 0.9 7e-10 38.4 0.9 2.3 1 1 0 1 1 1 1 Sirohaem biosynthesis protein C-terminal Sirohm_synth_M PF14824.6 EXF83753.1 - 7.7e-11 41.2 0.0 1.7e-10 40.1 0.0 1.6 1 0 0 1 1 1 1 Sirohaem biosynthesis protein central Rsm22 PF09243.10 EXF83754.1 - 6.7e-29 101.0 0.0 2.2e-28 99.3 0.0 1.8 1 1 0 1 1 1 1 Mitochondrial small ribosomal subunit Rsm22 Methyltransf_23 PF13489.6 EXF83754.1 - 0.00019 21.3 0.0 0.00056 19.8 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF83754.1 - 0.0029 18.3 0.3 0.093 13.4 0.0 3.0 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF83754.1 - 0.0062 16.3 0.1 0.32 10.8 0.0 3.0 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF83754.1 - 0.021 15.6 0.6 0.068 13.9 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_11 PF08241.12 EXF83754.1 - 0.048 14.3 0.0 0.5 11.0 0.0 2.4 2 0 0 2 2 2 0 Methyltransferase domain Ank_2 PF12796.7 EXF83755.1 - 6e-63 209.4 7.9 5.2e-11 43.0 0.3 6.9 2 1 6 8 8 8 8 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EXF83755.1 - 1.8e-55 184.3 6.4 4.1e-10 39.7 0.1 9.1 4 3 5 9 9 9 9 Ankyrin repeats (many copies) Ank_4 PF13637.6 EXF83755.1 - 1.6e-48 162.5 4.8 7.6e-09 35.9 0.0 8.0 4 2 6 10 10 9 9 Ankyrin repeats (many copies) Ank_3 PF13606.6 EXF83755.1 - 4.6e-48 155.6 4.5 0.00057 20.1 0.0 12.7 12 0 0 12 12 12 11 Ankyrin repeat Ank PF00023.30 EXF83755.1 - 3e-45 150.7 6.4 7.8e-05 22.9 0.0 12.2 11 1 0 11 11 11 10 Ankyrin repeat HET PF06985.11 EXF83755.1 - 3.6e-11 43.6 14.2 3.3e-10 40.5 0.0 3.5 2 2 1 3 3 2 2 Heterokaryon incompatibility protein (HET) DHR10 PF18595.1 EXF83755.1 - 0.0002 21.4 10.8 0.0026 17.8 12.5 2.0 2 0 0 2 2 2 1 Designed helical repeat protein 10 domain ERM PF00769.19 EXF83755.1 - 0.026 14.4 14.0 0.042 13.6 14.0 1.3 1 0 0 1 1 1 0 Ezrin/radixin/moesin family GAS PF13851.6 EXF83755.1 - 0.13 11.6 16.7 0.14 11.5 14.8 1.9 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding AAA_23 PF13476.6 EXF83755.1 - 0.22 12.0 5.0 0.13 12.7 2.6 1.8 2 0 0 2 2 2 0 AAA domain DUF948 PF06103.11 EXF83755.1 - 0.48 10.7 1.8 1.3 9.3 1.0 2.0 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF4140 PF13600.6 EXF83755.1 - 0.48 10.9 5.2 0.56 10.7 3.1 2.3 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) DivIVA PF05103.13 EXF83755.1 - 1 9.5 10.1 0.16 12.1 5.7 1.9 2 0 0 2 2 2 0 DivIVA protein APG6_N PF17675.1 EXF83755.1 - 1.4 9.4 13.6 4 8.0 13.6 1.8 1 0 0 1 1 1 0 Apg6 coiled-coil region Spc7 PF08317.11 EXF83755.1 - 2 7.2 15.7 3.4 6.5 15.7 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein Thioredoxin PF00085.20 EXF83756.1 - 1.5e-25 89.2 0.0 2.1e-25 88.7 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 EXF83756.1 - 6.8e-07 29.7 0.0 1.7e-06 28.4 0.0 1.6 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 EXF83756.1 - 6.3e-06 26.4 0.0 2.5e-05 24.5 0.0 1.8 1 1 0 1 1 1 1 Thioredoxin-like OST3_OST6 PF04756.13 EXF83756.1 - 1.9e-05 24.1 0.0 2.4e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family AhpC-TSA PF00578.21 EXF83756.1 - 0.00054 19.9 0.0 0.00093 19.1 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_9 PF14595.6 EXF83756.1 - 0.00059 19.6 0.0 0.00082 19.1 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin Redoxin PF08534.10 EXF83756.1 - 0.0016 18.1 0.0 0.0025 17.5 0.0 1.4 1 0 0 1 1 1 1 Redoxin Thioredoxin_7 PF13899.6 EXF83756.1 - 0.033 14.4 0.0 0.052 13.7 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin-like HyaE PF07449.11 EXF83756.1 - 0.11 12.4 0.0 0.41 10.6 0.0 1.8 2 0 0 2 2 2 0 Hydrogenase-1 expression protein HyaE Thioredoxin_4 PF13462.6 EXF83756.1 - 0.19 11.9 0.7 2.6 8.2 0.0 2.1 1 1 1 2 2 2 0 Thioredoxin Methyltrn_RNA_3 PF02598.17 EXF83757.1 - 1.8e-100 336.1 0.0 2.1e-100 336.0 0.0 1.0 1 0 0 1 1 1 1 Putative RNA methyltransferase Pectate_lyase_3 PF12708.7 EXF83758.1 - 5.1e-89 297.8 10.6 2.7e-79 266.0 0.9 3.5 3 0 0 3 3 3 2 Pectate lyase superfamily protein End_N_terminal PF12218.8 EXF83758.1 - 8.1e-07 28.6 0.8 0.024 14.3 0.1 2.6 2 0 0 2 2 2 2 N terminal extension of bacteriophage endosialidase NosD PF05048.13 EXF83758.1 - 0.019 14.3 0.6 0.055 12.7 0.5 1.9 1 1 0 1 1 1 0 Periplasmic copper-binding protein (NosD) LIAS_N PF16881.5 EXF83759.1 - 7.7e-18 64.9 0.0 1.5e-17 63.9 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of lipoyl synthase of Radical_SAM family Radical_SAM PF04055.21 EXF83759.1 - 3e-12 47.2 0.0 6.3e-12 46.2 0.0 1.6 1 1 0 1 1 1 1 Radical SAM superfamily Spore_GerAC PF05504.11 EXF83759.1 - 0.024 14.8 0.0 0.038 14.2 0.0 1.3 1 0 0 1 1 1 0 Spore germination B3/ GerAC like, C-terminal Type2_restr_D3 PF16902.5 EXF83759.1 - 0.061 13.2 0.0 0.5 10.3 0.0 2.2 2 0 0 2 2 2 0 Type-2 restriction enzyme D3 domain NusG_II PF07009.11 EXF83760.1 - 0.13 12.5 0.0 0.16 12.2 0.0 1.2 1 0 0 1 1 1 0 NusG domain II F-box-like PF12937.7 EXF83761.1 - 0.011 15.6 0.2 0.026 14.4 0.2 1.7 1 0 0 1 1 1 0 F-box-like Zn_clus PF00172.18 EXF83762.1 - 7.2e-07 29.2 9.7 2e-06 27.8 9.7 1.8 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain NAD_binding_10 PF13460.6 EXF83763.1 - 2.7e-10 40.5 0.0 6.4e-10 39.2 0.0 1.6 2 0 0 2 2 2 1 NAD(P)H-binding NmrA PF05368.13 EXF83763.1 - 3.5e-09 36.6 0.0 4.9e-09 36.1 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family Epimerase PF01370.21 EXF83763.1 - 0.0022 17.5 0.1 0.0037 16.8 0.1 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Shikimate_DH PF01488.20 EXF83763.1 - 0.0089 16.1 0.1 0.017 15.2 0.1 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Semialdhyde_dh PF01118.24 EXF83763.1 - 0.03 14.7 0.0 0.077 13.4 0.0 1.8 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain NAD_binding_4 PF07993.12 EXF83763.1 - 0.037 13.2 0.0 0.15 11.2 0.0 1.9 2 0 0 2 2 2 0 Male sterility protein Ldh_1_N PF00056.23 EXF83763.1 - 0.042 13.9 0.0 0.12 12.5 0.0 1.8 2 0 0 2 2 2 0 lactate/malate dehydrogenase, NAD binding domain DapB_N PF01113.20 EXF83763.1 - 0.12 12.5 0.0 0.23 11.6 0.0 1.5 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus F420_oxidored PF03807.17 EXF83763.1 - 0.13 12.8 1.0 0.31 11.6 0.1 2.1 2 1 1 3 3 3 0 NADP oxidoreductase coenzyme F420-dependent adh_short PF00106.25 EXF83764.1 - 4.5e-33 114.4 0.0 6.2e-33 113.9 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF83764.1 - 1.4e-19 70.6 0.0 3.1e-19 69.5 0.0 1.5 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 EXF83764.1 - 0.0078 15.7 0.0 0.018 14.5 0.0 1.6 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family Methyltransf_23 PF13489.6 EXF83764.1 - 0.15 11.8 0.0 0.27 11.0 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain PIF1 PF05970.14 EXF83765.1 - 3e-17 62.9 1.4 1.8e-10 40.5 0.0 3.1 2 1 1 3 3 3 3 PIF1-like helicase Herpes_Helicase PF02689.14 EXF83765.1 - 1.6e-06 26.4 0.0 2.4e-06 25.8 0.0 1.1 1 0 0 1 1 1 1 Helicase UvrD_C_2 PF13538.6 EXF83765.1 - 0.00013 21.7 0.0 0.00034 20.4 0.0 1.7 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_30 PF13604.6 EXF83765.1 - 0.0011 18.7 0.0 1.5 8.5 0.0 2.4 2 0 0 2 2 2 2 AAA domain PIF1 PF05970.14 EXF83766.1 - 7.7e-11 41.8 0.1 9.8e-11 41.4 0.1 1.1 1 0 0 1 1 1 1 PIF1-like helicase AAA_30 PF13604.6 EXF83766.1 - 7.7e-07 29.0 0.0 9.7e-07 28.7 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EXF83766.1 - 4.5e-05 23.8 0.1 5.6e-05 23.5 0.1 1.1 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 EXF83766.1 - 6.9e-05 22.3 0.1 0.0001 21.7 0.1 1.2 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_29 PF13555.6 EXF83766.1 - 0.0004 20.1 0.0 0.00091 18.9 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 EXF83766.1 - 0.00045 20.6 0.0 0.00061 20.2 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain DUF815 PF05673.13 EXF83766.1 - 0.001 18.3 0.0 0.0013 17.9 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF815) ABC_tran PF00005.27 EXF83766.1 - 0.0034 17.9 0.0 0.0049 17.4 0.0 1.3 1 0 0 1 1 1 1 ABC transporter ATPase_2 PF01637.18 EXF83766.1 - 0.0045 16.9 0.0 0.006 16.5 0.0 1.1 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea Pox_A32 PF04665.12 EXF83766.1 - 0.0067 15.9 0.0 0.0083 15.6 0.0 1.1 1 0 0 1 1 1 1 Poxvirus A32 protein MeaB PF03308.16 EXF83766.1 - 0.01 14.8 0.0 0.014 14.4 0.0 1.1 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Zeta_toxin PF06414.12 EXF83766.1 - 0.01 15.1 0.0 0.015 14.6 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin AAA_7 PF12775.7 EXF83766.1 - 0.018 14.6 0.1 0.028 13.9 0.1 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_32 PF13654.6 EXF83766.1 - 0.039 12.7 0.1 0.052 12.3 0.1 1.1 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 EXF83766.1 - 0.041 13.8 0.0 0.058 13.3 0.0 1.1 1 0 0 1 1 1 0 RsgA GTPase NB-ARC PF00931.22 EXF83766.1 - 0.043 13.0 0.1 0.056 12.6 0.1 1.1 1 0 0 1 1 1 0 NB-ARC domain Rad17 PF03215.15 EXF83766.1 - 0.045 13.7 0.0 0.062 13.2 0.0 1.2 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_10 PF12846.7 EXF83766.1 - 0.058 12.3 0.0 0.075 11.9 0.0 1.1 1 0 0 1 1 1 0 AAA-like domain AAA_22 PF13401.6 EXF83766.1 - 0.064 13.5 0.0 0.086 13.1 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 EXF83766.1 - 0.074 13.5 0.1 0.097 13.1 0.1 1.2 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EXF83766.1 - 0.081 12.6 0.1 0.092 12.4 0.1 1.2 1 0 0 1 1 1 0 Sigma-54 interaction domain RNA_helicase PF00910.22 EXF83766.1 - 0.089 13.2 0.0 0.13 12.7 0.0 1.3 1 0 0 1 1 1 0 RNA helicase AAA_28 PF13521.6 EXF83766.1 - 0.091 13.0 0.0 0.12 12.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.18 EXF83766.1 - 0.1 11.9 0.0 0.14 11.5 0.0 1.1 1 0 0 1 1 1 0 FtsK/SpoIIIE family Viral_helicase1 PF01443.18 EXF83766.1 - 0.13 12.0 0.0 0.17 11.6 0.0 1.2 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase T2SSE PF00437.20 EXF83766.1 - 0.23 10.5 0.0 0.28 10.2 0.0 1.1 1 0 0 1 1 1 0 Type II/IV secretion system protein Herpes_Helicase PF02689.14 EXF83766.1 - 0.27 9.1 0.0 0.3 8.9 0.0 1.0 1 0 0 1 1 1 0 Helicase FMN_dh PF01070.18 EXF83767.1 - 4.3e-112 374.6 0.0 5.7e-112 374.2 0.0 1.2 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.28 EXF83767.1 - 2.4e-18 66.0 0.0 5.2e-18 65.0 0.0 1.6 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Glu_synthase PF01645.17 EXF83767.1 - 2e-07 30.5 0.0 3.1e-07 29.9 0.0 1.3 1 0 0 1 1 1 1 Conserved region in glutamate synthase Glu_syn_central PF04898.14 EXF83767.1 - 7.3e-05 22.4 0.0 0.00011 21.8 0.0 1.2 1 0 0 1 1 1 1 Glutamate synthase central domain IMPDH PF00478.25 EXF83767.1 - 9.9e-05 21.5 0.6 0.00043 19.4 0.2 2.0 1 1 1 2 2 2 1 IMP dehydrogenase / GMP reductase domain ThiG PF05690.14 EXF83767.1 - 0.00026 20.4 0.1 0.13 11.5 0.0 2.3 2 0 0 2 2 2 2 Thiazole biosynthesis protein ThiG NMO PF03060.15 EXF83767.1 - 0.0016 17.9 1.0 0.0024 17.3 1.0 1.2 1 0 0 1 1 1 1 Nitronate monooxygenase His_biosynth PF00977.21 EXF83767.1 - 0.049 13.1 0.2 0.57 9.6 0.0 2.4 3 0 0 3 3 3 0 Histidine biosynthesis protein DHO_dh PF01180.21 EXF83767.1 - 0.13 11.4 0.1 0.33 10.1 0.1 1.7 1 1 0 1 1 1 0 Dihydroorotate dehydrogenase MFS_1 PF07690.16 EXF83768.1 - 1.5e-34 119.5 26.3 1.5e-34 119.5 26.3 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF3390 PF11870.8 EXF83768.1 - 0.029 14.7 0.0 0.064 13.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3390) DUF4519 PF15012.6 EXF83768.1 - 0.2 11.9 0.5 0.94 9.7 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4519) DUF3784 PF12650.7 EXF83768.1 - 6.7 7.0 10.5 27 5.0 0.1 4.3 4 0 0 4 4 4 0 Domain of unknown function (DUF3784) Glyco_hydro_61 PF03443.14 EXF83769.1 - 1.4e-44 152.5 0.0 2.3e-44 151.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 Glyco_hydr_30_2 PF14587.6 EXF83770.1 - 1.9e-14 54.1 1.3 6.5e-14 52.3 0.2 2.2 1 1 0 2 2 2 1 O-Glycosyl hydrolase family 30 Glyco_hydro_30C PF17189.4 EXF83770.1 - 3.9e-11 43.0 5.5 1.2e-10 41.5 5.5 1.9 1 0 0 1 1 1 1 Glycosyl hydrolase family 30 beta sandwich domain Glyco_hydro_59 PF02057.15 EXF83770.1 - 3.9e-08 32.9 0.1 5.7e-08 32.3 0.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 59 Glyco_hydro_30 PF02055.16 EXF83770.1 - 2.2e-07 30.2 0.4 3.3e-07 29.6 0.4 1.4 1 1 0 1 1 1 1 Glycosyl hydrolase family 30 TIM-barrel domain DUF1570 PF07607.11 EXF83770.1 - 0.29 11.4 1.5 1.3 9.3 0.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1570) AltA1 PF16541.5 EXF83771.1 - 4.1e-14 53.4 0.0 5.9e-14 52.9 0.0 1.1 1 0 0 1 1 1 1 Alternaria alternata allergen 1 PCI PF01399.27 EXF83772.1 - 3.1e-21 75.8 0.1 1e-20 74.2 0.1 1.9 1 0 0 1 1 1 1 PCI domain RPN5_C PF18098.1 EXF83772.1 - 2.1e-15 56.5 4.2 5.5e-15 55.2 4.2 1.8 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN5 C-terminal domain FSH1 PF03959.13 EXF83773.1 - 5.3e-60 202.7 0.0 6.5e-60 202.4 0.0 1.1 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Esterase_phd PF10503.9 EXF83773.1 - 0.0042 16.6 0.0 0.22 11.0 0.0 2.3 2 0 0 2 2 2 1 Esterase PHB depolymerase Abhydrolase_6 PF12697.7 EXF83773.1 - 0.01 16.5 3.9 0.022 15.4 3.9 1.5 1 1 0 1 1 1 0 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EXF83773.1 - 0.014 15.1 0.1 0.26 10.9 0.1 2.3 2 1 1 3 3 3 0 alpha/beta hydrolase fold DLH PF01738.18 EXF83773.1 - 0.03 13.9 0.0 5.1 6.6 0.0 2.2 2 0 0 2 2 2 0 Dienelactone hydrolase family Hydrolase_4 PF12146.8 EXF83773.1 - 0.033 13.5 0.2 0.27 10.5 0.0 2.3 2 1 0 2 2 2 0 Serine aminopeptidase, S33 Palm_thioest PF02089.15 EXF83773.1 - 0.11 12.4 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 Palmitoyl protein thioesterase Abhydrolase_2 PF02230.16 EXF83773.1 - 0.13 12.1 0.0 31 4.3 0.1 2.9 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase ATP-synt_J PF04911.12 EXF83774.1 - 1e-27 95.4 0.7 1.2e-27 95.3 0.7 1.0 1 0 0 1 1 1 1 ATP synthase j chain NIPSNAP PF07978.13 EXF83775.1 - 3.2e-41 139.7 0.6 8.3e-30 103.0 0.1 2.5 2 0 0 2 2 2 2 NIPSNAP Uds1 PF15456.6 EXF83775.1 - 0.024 14.8 1.4 0.049 13.8 1.4 1.5 1 0 0 1 1 1 0 Up-regulated During Septation SspB PF04386.13 EXF83775.1 - 0.38 10.6 3.6 0.72 9.7 3.6 1.4 1 0 0 1 1 1 0 Stringent starvation protein B SR-25 PF10500.9 EXF83775.1 - 6 6.4 14.2 9.5 5.8 14.2 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Rogdi_lz PF10259.9 EXF83776.1 - 6.5e-93 311.0 0.1 7.4e-93 310.9 0.1 1.0 1 0 0 1 1 1 1 Rogdi leucine zipper containing protein Rpp20 PF12328.8 EXF83777.1 - 1e-28 100.0 0.1 1.5e-28 99.5 0.1 1.2 1 0 0 1 1 1 1 Rpp20 subunit of nuclear RNase MRP and P Alba PF01918.21 EXF83777.1 - 5e-13 48.7 0.0 7.7e-13 48.1 0.0 1.3 1 0 0 1 1 1 1 Alba Peptidase_C69 PF03577.15 EXF83779.1 - 3.5e-22 78.9 0.1 5.4e-22 78.3 0.1 1.2 1 0 0 1 1 1 1 Peptidase family C69 Acyl_transf_3 PF01757.22 EXF83780.1 - 1.4e-33 116.4 27.7 5.4e-33 114.5 27.7 1.8 1 1 0 1 1 1 1 Acyltransferase family DUF418 PF04235.12 EXF83780.1 - 0.00013 22.0 6.1 0.00013 22.0 6.1 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF418) PLN_propep PF16485.5 EXF83781.1 - 4.1e-05 23.2 0.0 0.00012 21.7 0.0 1.8 1 0 0 1 1 1 1 Protealysin propeptide Ifi-6-16 PF06140.13 EXF83782.1 - 2e-08 34.0 26.6 3.4e-08 33.3 26.2 1.6 1 1 1 2 2 2 1 Interferon-induced 6-16 family DUF2205 PF10224.9 EXF83783.1 - 0.0003 20.7 3.1 0.00052 19.9 3.1 1.3 1 0 0 1 1 1 1 Short coiled-coil protein DUF812 PF05667.11 EXF83783.1 - 0.00034 19.7 2.1 0.0004 19.4 2.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF812) YabA PF06156.13 EXF83783.1 - 0.0029 18.2 1.4 0.0044 17.6 1.4 1.2 1 0 0 1 1 1 1 Initiation control protein YabA ZapB PF06005.12 EXF83783.1 - 0.0041 17.5 2.9 0.0041 17.5 2.9 1.7 1 1 0 1 1 1 1 Cell division protein ZapB NRBF2 PF08961.10 EXF83783.1 - 0.0062 16.2 0.4 0.0081 15.8 0.4 1.3 1 0 0 1 1 1 1 Nuclear receptor-binding factor 2, autophagy regulator UPF0242 PF06785.11 EXF83783.1 - 0.0067 16.5 2.3 0.0088 16.2 2.3 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus Spc7 PF08317.11 EXF83783.1 - 0.0082 15.1 1.6 0.01 14.8 1.6 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein Prominin PF05478.11 EXF83783.1 - 0.012 13.6 0.3 0.015 13.3 0.3 1.0 1 0 0 1 1 1 0 Prominin Sipho_Gp157 PF05565.11 EXF83783.1 - 0.015 15.3 1.0 0.024 14.6 1.0 1.3 1 0 0 1 1 1 0 Siphovirus Gp157 Use1 PF09753.9 EXF83783.1 - 0.016 15.0 0.2 0.019 14.7 0.2 1.1 1 0 0 1 1 1 0 Membrane fusion protein Use1 FlgN PF05130.12 EXF83783.1 - 0.017 15.6 0.9 0.023 15.2 0.9 1.2 1 0 0 1 1 1 0 FlgN protein TSC22 PF01166.18 EXF83783.1 - 0.027 14.8 1.1 0.049 14.0 1.1 1.5 1 0 0 1 1 1 0 TSC-22/dip/bun family CENP-H PF05837.12 EXF83783.1 - 0.049 14.0 2.1 0.065 13.6 2.1 1.3 1 0 0 1 1 1 0 Centromere protein H (CENP-H) Herpes_UL6 PF01763.16 EXF83783.1 - 0.056 12.0 0.3 0.065 11.7 0.3 1.1 1 0 0 1 1 1 0 Herpesvirus UL6 like DUF5082 PF16888.5 EXF83783.1 - 0.097 13.0 2.9 0.16 12.2 2.5 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF5082) DivIC PF04977.15 EXF83783.1 - 0.19 11.6 2.6 0.37 10.6 2.6 1.5 1 1 0 1 1 1 0 Septum formation initiator CPSF100_C PF13299.6 EXF83783.1 - 0.31 11.2 2.4 0.42 10.8 2.4 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Cut12 PF11500.8 EXF83783.1 - 0.71 9.8 3.6 5.2 7.0 0.6 2.1 1 1 1 2 2 2 0 Spindle pole body formation-associated protein Kelch_5 PF13854.6 EXF83784.1 - 1.1e-13 50.8 4.6 2.7e-05 24.1 0.0 5.8 7 0 0 7 7 7 3 Kelch motif SKG6 PF08693.10 EXF83784.1 - 0.00017 20.9 0.2 0.00038 19.8 0.2 1.5 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Kelch_2 PF07646.15 EXF83784.1 - 0.00026 20.8 1.5 2.2 8.4 0.0 4.7 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 EXF83784.1 - 0.0051 16.8 9.1 0.025 14.6 0.3 5.3 6 1 0 6 6 6 1 Galactose oxidase, central domain Herpes_gE PF02480.16 EXF83784.1 - 0.017 13.9 0.0 0.025 13.4 0.0 1.1 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E Kelch_1 PF01344.25 EXF83784.1 - 0.18 11.4 3.5 17 5.1 0.2 4.3 4 0 0 4 4 4 0 Kelch motif Kelch_6 PF13964.6 EXF83784.1 - 1.4 9.4 7.4 6.6 7.2 0.0 4.8 5 1 0 5 5 5 0 Kelch motif Gram_pos_anchor PF00746.21 EXF83784.1 - 1.5 8.8 3.8 3.5 7.7 3.8 1.6 1 0 0 1 1 1 0 LPXTG cell wall anchor motif GRDP-like PF07173.12 EXF83785.1 - 1.8e-21 77.3 0.6 3.5e-17 63.4 0.0 2.8 2 1 1 3 3 3 2 Glycine-rich domain-containing protein-like Peroxidase_2 PF01328.17 EXF83786.1 - 3.7e-49 167.8 0.0 4.4e-49 167.6 0.0 1.0 1 0 0 1 1 1 1 Peroxidase, family 2 WD40 PF00400.32 EXF83788.1 - 6e-19 68.0 11.2 0.00045 21.0 0.0 8.1 8 0 0 8 8 8 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EXF83788.1 - 5.7e-06 26.5 0.2 0.53 10.6 0.1 4.5 3 2 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EXF83788.1 - 0.26 10.5 0.0 12 5.2 0.0 2.9 3 0 0 3 3 3 0 WD40-like domain SKG6 PF08693.10 EXF83789.1 - 1.1e-07 31.2 7.1 1.9e-07 30.4 7.1 1.4 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Stevor PF17410.2 EXF83789.1 - 0.24 10.9 0.1 0.36 10.3 0.1 1.3 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame GT87 PF09594.10 EXF83789.1 - 0.29 10.8 9.5 0.45 10.2 9.5 1.2 1 0 0 1 1 1 0 Glycosyltransferase family 87 CorA PF01544.18 EXF83790.1 - 3.1e-08 33.3 0.0 7.6e-08 32.0 0.0 1.6 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein ADH_zinc_N_2 PF13602.6 EXF83791.1 - 4.4e-09 37.5 0.0 6.9e-09 36.9 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 EXF83791.1 - 6.9e-08 32.5 0.0 9.4e-08 32.1 0.0 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Lon_C PF05362.13 EXF83791.1 - 0.072 12.6 0.0 0.16 11.5 0.0 1.5 2 0 0 2 2 2 0 Lon protease (S16) C-terminal proteolytic domain Peptidase_S10 PF00450.22 EXF83792.1 - 2.2e-87 294.2 0.0 2.8e-87 293.8 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase Abhydrolase_6 PF12697.7 EXF83792.1 - 0.00045 20.9 0.4 0.058 14.0 0.2 2.5 3 0 0 3 3 3 2 Alpha/beta hydrolase family GDC-P PF02347.16 EXF83793.1 - 3.1e-171 570.0 0.0 9.3e-161 535.4 0.0 3.0 2 1 0 2 2 2 2 Glycine cleavage system P-protein Aminotran_5 PF00266.19 EXF83793.1 - 6.5e-10 38.5 0.0 0.00059 18.9 0.0 2.3 2 0 0 2 2 2 2 Aminotransferase class-V Beta_elim_lyase PF01212.21 EXF83793.1 - 1.4e-05 24.5 0.0 2.4e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.20 EXF83793.1 - 0.0044 15.6 0.0 0.01 14.4 0.0 1.5 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme B12-binding PF02310.19 EXF83793.1 - 0.017 15.2 0.4 0.09 12.8 0.1 2.4 3 0 0 3 3 3 0 B12 binding domain Tom5 PF10642.9 EXF83794.1 - 1.3e-15 57.1 0.5 2.1e-15 56.5 0.5 1.3 1 0 0 1 1 1 1 Mitochondrial import receptor subunit or translocase Nup54 PF13874.6 EXF83795.1 - 6.1e-39 133.3 1.7 1.1e-38 132.5 0.2 1.9 2 0 0 2 2 2 1 Nucleoporin complex subunit 54 Nup54_57_C PF18570.1 EXF83795.1 - 5.1e-16 57.9 10.8 1.1e-15 56.9 7.5 2.3 2 0 0 2 2 2 1 NUP57/Nup54 C-terminal domain DivIVA PF05103.13 EXF83795.1 - 0.0016 18.6 1.3 0.0016 18.6 1.3 1.7 2 0 0 2 2 2 1 DivIVA protein Adhesin_P1_N PF18652.1 EXF83795.1 - 0.0027 17.7 0.8 0.0069 16.4 0.8 1.6 1 0 0 1 1 1 1 Adhesin P1 N-terminal domain DUF948 PF06103.11 EXF83795.1 - 0.038 14.2 0.7 2 8.7 0.1 2.7 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) YliH PF10799.8 EXF83795.1 - 0.041 13.8 0.3 0.1 12.5 0.1 1.7 1 1 0 1 1 1 0 Biofilm formation protein (YliH/bssR) Cnn_1N PF07989.11 EXF83795.1 - 0.059 13.5 5.1 6.1 7.1 1.3 2.8 3 0 0 3 3 3 0 Centrosomin N-terminal motif 1 ABC_tran_CTD PF16326.5 EXF83795.1 - 0.066 13.5 6.1 2 8.7 1.1 3.3 3 0 0 3 3 3 0 ABC transporter C-terminal domain V-SNARE_C PF12352.8 EXF83795.1 - 0.069 13.5 0.4 1.4 9.2 0.1 2.3 2 0 0 2 2 2 0 Snare region anchored in the vesicle membrane C-terminus DUF4337 PF14235.6 EXF83795.1 - 0.096 12.8 1.6 0.15 12.1 1.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) HTH_39 PF14090.6 EXF83795.1 - 0.1 12.4 0.1 0.18 11.6 0.1 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain FlaC_arch PF05377.11 EXF83795.1 - 0.31 11.5 1.8 4.6 7.7 0.3 2.8 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) Prefoldin_2 PF01920.20 EXF83795.1 - 4.7 7.2 8.7 2 8.4 4.6 2.4 2 1 0 2 2 2 0 Prefoldin subunit CHCH PF06747.13 EXF83796.1 - 4.2e-07 29.9 13.2 1.8e-05 24.7 3.3 2.6 3 0 0 3 3 3 2 CHCH domain CX9C PF16860.5 EXF83796.1 - 5.6e-05 23.1 6.1 0.0032 17.4 3.3 2.2 2 0 0 2 2 2 2 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Cmc1 PF08583.10 EXF83796.1 - 0.0082 16.1 10.4 0.11 12.6 0.7 2.2 1 1 1 2 2 2 2 Cytochrome c oxidase biogenesis protein Cmc1 like Pet191_N PF10203.9 EXF83796.1 - 0.17 12.2 9.5 0.98 9.8 1.1 2.8 1 1 2 3 3 3 0 Cytochrome c oxidase assembly protein PET191 CAP PF00188.26 EXF83797.1 - 6.5e-22 78.7 3.0 9e-22 78.2 3.0 1.2 1 0 0 1 1 1 1 Cysteine-rich secretory protein family Med13_C PF06333.12 EXF83797.1 - 0.031 13.5 9.1 0.042 13.1 9.1 1.2 1 0 0 1 1 1 0 Mediator complex subunit 13 C-terminal domain SSF PF00474.17 EXF83798.1 - 2.1e-24 86.2 29.7 3.1e-24 85.6 29.7 1.3 1 0 0 1 1 1 1 Sodium:solute symporter family DUF3087 PF11286.8 EXF83798.1 - 4.9 6.6 6.5 0.47 9.9 0.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3087) Thioredox_DsbH PF03190.15 EXF83799.1 - 4.4e-58 195.8 0.0 6.9e-58 195.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF255 Thioredoxin_7 PF13899.6 EXF83799.1 - 0.0055 16.9 0.0 0.012 15.8 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin-like GlcNAc_2-epim PF07221.11 EXF83799.1 - 0.0097 15.2 0.2 0.017 14.4 0.2 1.3 1 0 0 1 1 1 1 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) Glyco_hydro_76 PF03663.14 EXF83799.1 - 0.12 11.8 0.5 0.5 9.8 0.1 1.9 2 0 0 2 2 2 0 Glycosyl hydrolase family 76 TRAM_LAG1_CLN8 PF03798.16 EXF83800.1 - 5.9e-46 156.7 18.1 5.9e-46 156.7 18.1 1.6 2 0 0 2 2 2 1 TLC domain TRAM1 PF08390.11 EXF83800.1 - 1.6e-22 78.9 0.3 9.7e-22 76.4 0.0 2.5 2 0 0 2 2 2 1 TRAM1-like protein TMEM154 PF15102.6 EXF83800.1 - 0.074 13.0 0.3 0.2 11.6 0.0 1.7 2 0 0 2 2 2 0 TMEM154 protein family Bax1-I PF01027.20 EXF83801.1 - 5e-52 176.7 28.5 5.8e-52 176.5 28.5 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 Spore_YhaL PF14147.6 EXF83801.1 - 0.12 12.1 0.6 0.7 9.6 0.1 2.6 2 0 0 2 2 2 0 Sporulation protein YhaL Septin PF00735.18 EXF83802.1 - 4.9e-107 357.4 0.0 1.1e-106 356.3 0.0 1.5 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.23 EXF83802.1 - 0.00013 22.0 0.0 0.00032 20.8 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 EXF83802.1 - 0.008 16.3 4.9 1.4 8.9 0.0 3.1 2 1 1 3 3 3 2 Dynamin family AAA_23 PF13476.6 EXF83802.1 - 0.017 15.6 3.7 4.6 7.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain IIGP PF05049.13 EXF83802.1 - 0.027 13.6 0.0 0.052 12.6 0.0 1.4 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) EB1 PF03271.17 EXF83802.1 - 0.037 14.3 1.2 1.8 8.9 1.3 2.6 2 0 0 2 2 2 0 EB1-like C-terminal motif GTP_EFTU PF00009.27 EXF83802.1 - 0.26 10.8 0.8 1.1 8.8 0.0 2.2 3 0 0 3 3 3 0 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EXF83802.1 - 0.32 10.9 5.4 0.13 12.1 1.1 2.5 2 1 0 2 2 2 0 RsgA GTPase AAA_22 PF13401.6 EXF83802.1 - 0.4 10.9 1.7 0.53 10.6 0.2 2.0 2 1 0 2 2 2 0 AAA domain WD40 PF00400.32 EXF83803.1 - 7.2e-05 23.5 0.1 1.7 9.6 0.0 3.5 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EXF83803.1 - 0.044 14.1 0.0 0.37 11.1 0.0 2.5 2 1 2 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain Nbas_N PF15492.6 EXF83803.1 - 0.11 11.8 0.0 0.34 10.2 0.0 1.7 1 1 0 1 1 1 0 Neuroblastoma-amplified sequence, N terminal Ge1_WD40 PF16529.5 EXF83803.1 - 0.12 11.3 0.1 3.9 6.3 0.0 2.1 1 1 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein IKI3 PF04762.12 EXF83803.1 - 0.13 10.2 0.0 0.18 9.8 0.0 1.2 1 0 0 1 1 1 0 IKI3 family RRM_1 PF00076.22 EXF83804.1 - 1.2e-14 53.9 0.0 1.5e-13 50.4 0.0 2.4 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EXF83804.1 - 0.0023 18.0 0.0 0.0058 16.7 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif DLIC PF05783.11 EXF83805.1 - 2.3e-26 92.7 0.3 2.9e-25 89.1 0.0 2.5 2 2 0 2 2 2 1 Dynein light intermediate chain (DLIC) Cu_amine_oxid PF01179.20 EXF83807.1 - 1.1e-152 508.7 0.0 1.3e-152 508.4 0.0 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN2 PF02727.16 EXF83807.1 - 4.3e-05 23.6 0.1 0.00012 22.3 0.0 1.8 2 0 0 2 2 2 1 Copper amine oxidase, N2 domain Gly_transf_sug PF04488.15 EXF83808.1 - 2.7e-14 53.6 0.0 5.8e-14 52.5 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif AMP-binding PF00501.28 EXF83809.1 - 7.8e-94 314.6 0.0 9.4e-94 314.4 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EXF83809.1 - 3.6e-19 69.5 0.1 9.3e-19 68.2 0.1 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain QRPTase_C PF01729.19 EXF83810.1 - 4.6e-55 186.0 1.3 5.5e-55 185.7 0.4 1.6 2 0 0 2 2 2 1 Quinolinate phosphoribosyl transferase, C-terminal domain QRPTase_N PF02749.16 EXF83810.1 - 3.3e-15 55.9 0.0 2.1e-14 53.3 0.0 2.2 1 1 0 1 1 1 1 Quinolinate phosphoribosyl transferase, N-terminal domain zf-C2H2_jaz PF12171.8 EXF83810.1 - 0.043 14.1 0.3 0.043 14.1 0.3 2.2 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 EXF83810.1 - 0.069 14.0 5.3 0.38 11.7 0.4 3.1 3 0 0 3 3 3 0 C2H2-type zinc finger IGPS PF00218.21 EXF83810.1 - 0.23 10.6 0.2 0.43 9.7 0.2 1.4 1 0 0 1 1 1 0 Indole-3-glycerol phosphate synthase PLDc_2 PF13091.6 EXF83812.1 - 8.9e-08 32.1 0.1 0.0028 17.6 0.0 2.8 3 0 0 3 3 3 2 PLD-like domain PLDc PF00614.22 EXF83812.1 - 0.12 12.7 1.0 5.2 7.4 0.0 3.1 3 0 0 3 3 3 0 Phospholipase D Active site motif Fungal_trans PF04082.18 EXF83813.1 - 5.2e-13 48.6 0.3 9.2e-13 47.8 0.3 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF83813.1 - 7.8e-08 32.3 15.4 1.3e-07 31.6 15.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ABC2_membrane PF01061.24 EXF83814.1 - 7e-79 264.1 48.0 1.7e-45 155.0 21.0 2.5 3 0 0 3 3 2 2 ABC-2 type transporter ABC_tran PF00005.27 EXF83814.1 - 7e-46 156.1 0.1 1.5e-22 80.6 0.0 2.5 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.12 EXF83814.1 - 4.2e-26 90.7 0.5 5.9e-22 77.4 0.1 3.2 2 0 0 2 2 2 2 CDR ABC transporter ABC2_membrane_3 PF12698.7 EXF83814.1 - 4.2e-09 36.0 8.0 4.2e-09 36.0 8.0 2.9 2 2 0 2 2 2 1 ABC-2 family transporter protein AAA_16 PF13191.6 EXF83814.1 - 2.8e-06 27.8 0.0 0.0042 17.5 0.0 2.7 2 0 0 2 2 2 2 AAA ATPase domain AAA_21 PF13304.6 EXF83814.1 - 2.1e-05 24.5 0.0 0.061 13.1 0.0 3.3 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EXF83814.1 - 3.7e-05 23.3 0.2 0.27 10.6 0.0 3.3 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 EXF83814.1 - 4.2e-05 23.5 0.3 0.0028 17.6 0.1 2.3 2 0 0 2 2 2 1 RsgA GTPase AAA_29 PF13555.6 EXF83814.1 - 0.00033 20.3 1.2 0.052 13.3 0.1 3.5 3 0 0 3 3 3 1 P-loop containing region of AAA domain AAA_22 PF13401.6 EXF83814.1 - 0.00069 19.9 0.0 0.35 11.2 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EXF83814.1 - 0.0064 17.0 0.0 1.1 9.8 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EXF83814.1 - 0.013 15.7 0.0 0.44 10.7 0.0 2.6 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 EXF83814.1 - 0.019 14.9 0.1 0.65 9.9 0.1 2.5 2 0 0 2 2 2 0 NACHT domain ATPase_2 PF01637.18 EXF83814.1 - 0.026 14.4 0.0 2.1 8.2 0.0 2.4 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_30 PF13604.6 EXF83814.1 - 0.027 14.2 0.0 0.82 9.3 0.2 2.3 2 0 0 2 2 2 0 AAA domain PduV-EutP PF10662.9 EXF83814.1 - 0.033 13.9 0.1 1.9 8.2 0.1 2.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Rad17 PF03215.15 EXF83814.1 - 0.034 14.0 0.0 0.67 9.8 0.0 2.5 2 1 0 2 2 2 0 Rad17 P-loop domain AAA PF00004.29 EXF83814.1 - 0.046 14.1 0.0 13 6.2 0.0 3.1 3 0 0 3 3 2 0 ATPase family associated with various cellular activities (AAA) Roc PF08477.13 EXF83814.1 - 0.056 13.7 0.2 3 8.1 0.0 3.1 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase AAA_25 PF13481.6 EXF83814.1 - 0.057 13.0 0.2 0.35 10.4 0.1 2.1 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 EXF83814.1 - 0.059 13.5 0.1 4.5 7.4 0.1 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_28 PF13521.6 EXF83814.1 - 0.079 13.2 0.0 0.36 11.1 0.1 2.1 2 0 0 2 2 1 0 AAA domain cobW PF02492.19 EXF83814.1 - 0.089 12.4 0.2 1.6 8.3 0.1 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain DnaB_C PF03796.15 EXF83814.1 - 0.11 11.8 0.0 2.2 7.5 0.0 2.2 2 0 0 2 2 2 0 DnaB-like helicase C terminal domain AAA_19 PF13245.6 EXF83814.1 - 0.11 12.8 0.1 13 6.1 0.0 2.7 2 0 0 2 2 2 0 AAA domain RuvB_N PF05496.12 EXF83814.1 - 0.12 12.1 0.1 18 5.1 0.0 2.5 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain TsaE PF02367.17 EXF83814.1 - 0.17 11.9 0.1 0.59 10.1 0.1 1.8 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NB-ARC PF00931.22 EXF83814.1 - 0.23 10.6 0.4 6.3 5.9 0.2 2.3 2 0 0 2 2 2 0 NB-ARC domain DUF2207 PF09972.9 EXF83818.1 - 0.16 10.7 0.2 5.7 5.6 0.0 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) DUF5523 PF17661.1 EXF83820.1 - 0.083 12.6 0.2 0.12 12.0 0.2 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5523) Cu-oxidase_3 PF07732.15 EXF83821.1 - 3.3e-47 159.4 8.3 2.5e-42 143.7 0.4 3.7 3 2 0 3 3 3 2 Multicopper oxidase Cu-oxidase_2 PF07731.14 EXF83821.1 - 1.1e-36 125.6 10.3 7.2e-32 110.0 2.9 3.8 3 1 0 3 3 3 3 Multicopper oxidase Cu-oxidase PF00394.22 EXF83821.1 - 3.8e-34 118.1 1.6 6e-33 114.2 0.1 2.7 3 0 0 3 3 3 1 Multicopper oxidase Shikimate_dh_N PF08501.11 EXF83822.1 - 4.4e-18 65.3 0.0 7.7e-18 64.5 0.0 1.4 1 0 0 1 1 1 1 Shikimate dehydrogenase substrate binding domain Shikimate_DH PF01488.20 EXF83822.1 - 0.021 14.9 0.0 0.038 14.0 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase AP_endonuc_2 PF01261.24 EXF83823.1 - 6.9e-30 104.1 0.1 1.2e-29 103.3 0.0 1.4 2 0 0 2 2 2 1 Xylose isomerase-like TIM barrel IucA_IucC PF04183.12 EXF83823.1 - 0.05 13.1 0.1 0.077 12.5 0.1 1.3 1 0 0 1 1 1 0 IucA / IucC family Cu-oxidase_2 PF07731.14 EXF83823.1 - 0.14 11.9 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 Multicopper oxidase Fungal_trans PF04082.18 EXF83824.1 - 5e-09 35.6 0.8 8.8e-09 34.8 0.8 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF83824.1 - 1.9e-06 27.9 11.7 3.2e-06 27.1 11.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain AAA PF00004.29 EXF83825.1 - 8.4e-19 68.3 0.0 1.5e-18 67.4 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EXF83825.1 - 0.00014 22.3 0.2 0.00032 21.1 0.2 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EXF83825.1 - 0.00069 19.9 0.1 0.0094 16.2 0.0 2.4 1 1 1 2 2 2 1 AAA domain Zot PF05707.12 EXF83825.1 - 0.00072 19.2 0.4 0.0052 16.5 0.1 2.1 1 1 1 2 2 2 1 Zonular occludens toxin (Zot) AAA_14 PF13173.6 EXF83825.1 - 0.0033 17.5 0.0 0.0078 16.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EXF83825.1 - 0.0036 17.5 0.0 0.012 15.8 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_11 PF13086.6 EXF83825.1 - 0.019 14.7 0.1 0.045 13.5 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 EXF83825.1 - 0.02 14.9 0.0 0.045 13.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 EXF83825.1 - 0.021 14.9 0.0 0.04 14.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) AAA_18 PF13238.6 EXF83825.1 - 0.034 14.7 0.1 0.14 12.7 0.0 2.2 2 1 0 2 2 1 0 AAA domain AAA_24 PF13479.6 EXF83825.1 - 0.04 13.7 0.0 0.09 12.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 EXF83825.1 - 0.049 13.4 0.0 0.092 12.5 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein TIP49 PF06068.13 EXF83825.1 - 0.066 12.4 0.0 0.1 11.8 0.0 1.2 1 0 0 1 1 1 0 TIP49 P-loop domain NACHT PF05729.12 EXF83825.1 - 0.077 12.9 0.1 0.54 10.2 0.0 2.0 1 1 1 2 2 2 0 NACHT domain IFT81_CH PF18383.1 EXF83825.1 - 0.08 13.2 0.0 0.43 10.9 0.0 2.1 2 0 0 2 2 2 0 Intraflagellar transport 81 calponin homology domain Viral_helicase1 PF01443.18 EXF83825.1 - 0.15 11.8 0.0 0.28 10.9 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_19 PF13245.6 EXF83825.1 - 0.19 12.1 0.1 0.43 10.9 0.1 1.6 1 0 0 1 1 1 0 AAA domain DHquinase_II PF01220.19 EXF83827.1 - 8.9e-62 206.8 0.4 1e-61 206.6 0.4 1.0 1 0 0 1 1 1 1 Dehydroquinase class II SnoaL_4 PF13577.6 EXF83828.1 - 4.1e-08 33.4 0.1 5.8e-08 32.9 0.1 1.1 1 0 0 1 1 1 1 SnoaL-like domain Shikimate_dh_N PF08501.11 EXF83829.1 - 1.7e-21 76.3 0.1 3e-21 75.4 0.1 1.4 1 0 0 1 1 1 1 Shikimate dehydrogenase substrate binding domain SDH_C PF18317.1 EXF83829.1 - 1e-12 47.6 1.0 2.1e-12 46.6 1.0 1.6 1 0 0 1 1 1 1 Shikimate 5'-dehydrogenase C-terminal domain Shikimate_DH PF01488.20 EXF83829.1 - 1.5e-08 34.8 0.0 2.4e-08 34.1 0.0 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase DHquinase_I PF01487.15 EXF83830.1 - 2.6e-22 80.2 0.0 3.8e-22 79.7 0.0 1.2 1 0 0 1 1 1 1 Type I 3-dehydroquinase Shikimate_dh_N PF08501.11 EXF83830.1 - 1.5e-20 73.2 0.0 4.1e-20 71.8 0.0 1.8 1 0 0 1 1 1 1 Shikimate dehydrogenase substrate binding domain SKI PF01202.22 EXF83830.1 - 6.6e-16 58.8 0.0 1.2e-15 58.0 0.0 1.4 1 0 0 1 1 1 1 Shikimate kinase SDH_C PF18317.1 EXF83830.1 - 1.5e-07 31.0 0.0 3.2e-07 30.0 0.0 1.6 1 0 0 1 1 1 1 Shikimate 5'-dehydrogenase C-terminal domain Shikimate_DH PF01488.20 EXF83830.1 - 2.3e-07 31.0 0.0 4.4e-07 30.0 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase AAA_33 PF13671.6 EXF83830.1 - 0.018 15.2 0.0 0.064 13.4 0.0 1.9 2 0 0 2 2 2 0 AAA domain NAD_binding_7 PF13241.6 EXF83830.1 - 0.029 14.8 0.0 0.065 13.7 0.0 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding F420_oxidored PF03807.17 EXF83830.1 - 0.13 12.9 0.0 0.78 10.4 0.0 2.1 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent ABC2_membrane PF01061.24 EXF83831.1 - 3.4e-79 265.1 50.0 2.3e-43 148.1 18.2 2.5 2 0 0 2 2 2 2 ABC-2 type transporter PDR_CDR PF06422.12 EXF83831.1 - 5.8e-35 119.1 0.1 1.1e-30 105.4 0.0 3.9 4 1 1 5 5 2 2 CDR ABC transporter ABC_tran PF00005.27 EXF83831.1 - 5.8e-32 111.1 0.0 4.9e-16 59.5 0.0 3.5 4 0 0 4 4 4 2 ABC transporter ABC_trans_N PF14510.6 EXF83831.1 - 6.1e-16 58.8 0.1 1.7e-15 57.4 0.1 1.8 1 0 0 1 1 1 1 ABC-transporter N-terminal AAA_16 PF13191.6 EXF83831.1 - 1.1e-08 35.7 0.5 0.00012 22.5 0.1 2.4 2 0 0 2 2 2 2 AAA ATPase domain AAA_25 PF13481.6 EXF83831.1 - 3.2e-07 30.1 0.0 2e-05 24.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 EXF83831.1 - 3.6e-07 29.8 1.1 0.0003 20.5 0.2 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_33 PF13671.6 EXF83831.1 - 4.2e-07 30.2 0.0 0.0076 16.4 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 EXF83831.1 - 1.2e-05 25.9 0.0 0.0087 16.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 EXF83831.1 - 1.4e-05 25.1 0.0 0.0026 17.7 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase AAA_28 PF13521.6 EXF83831.1 - 4.6e-05 23.7 0.0 0.017 15.3 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_21 PF13304.6 EXF83831.1 - 5.4e-05 23.1 0.0 0.032 14.0 0.0 3.0 3 0 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EXF83831.1 - 0.00019 20.9 0.0 0.11 11.9 0.0 2.8 3 0 0 3 3 3 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 EXF83831.1 - 0.0003 21.1 0.0 0.55 10.5 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_30 PF13604.6 EXF83831.1 - 0.0009 19.0 0.3 0.06 13.1 0.1 2.3 2 0 0 2 2 2 1 AAA domain AAA_23 PF13476.6 EXF83831.1 - 0.0013 19.3 0.0 0.0033 17.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain ABC2_membrane_3 PF12698.7 EXF83831.1 - 0.0017 17.5 7.7 0.0017 17.5 7.7 2.9 3 0 0 3 3 2 2 ABC-2 family transporter protein AAA_17 PF13207.6 EXF83831.1 - 0.0027 18.1 0.2 0.25 11.8 0.0 2.4 2 0 0 2 2 2 1 AAA domain cobW PF02492.19 EXF83831.1 - 0.0034 17.0 2.0 0.5 9.9 0.2 2.4 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_5 PF07728.14 EXF83831.1 - 0.0066 16.5 0.1 0.62 10.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) NACHT PF05729.12 EXF83831.1 - 0.0072 16.3 0.6 1.1 9.1 0.0 2.8 3 0 0 3 3 2 1 NACHT domain AAA PF00004.29 EXF83831.1 - 0.0081 16.6 0.0 5.7 7.4 0.0 2.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 EXF83831.1 - 0.011 16.1 0.0 1.3 9.5 0.0 3.1 3 0 0 3 3 2 0 RNA helicase Rad17 PF03215.15 EXF83831.1 - 0.023 14.6 0.0 1 9.3 0.0 2.3 2 0 0 2 2 2 0 Rad17 P-loop domain IstB_IS21 PF01695.17 EXF83831.1 - 0.025 14.3 0.0 3.9 7.2 0.0 2.5 2 0 0 2 2 2 0 IstB-like ATP binding protein MMR_HSR1 PF01926.23 EXF83831.1 - 0.027 14.6 0.0 2.9 8.0 0.0 2.6 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_14 PF13173.6 EXF83831.1 - 0.027 14.5 0.0 1.9 8.6 0.0 2.7 2 0 0 2 2 2 0 AAA domain T2SSE PF00437.20 EXF83831.1 - 0.064 12.3 0.0 3.1 6.8 0.0 2.4 2 0 0 2 2 2 0 Type II/IV secretion system protein PDR_assoc PF08370.11 EXF83831.1 - 0.12 12.1 0.0 0.12 12.1 0.0 3.7 4 0 0 4 4 3 0 Plant PDR ABC transporter associated Zeta_toxin PF06414.12 EXF83831.1 - 0.17 11.2 0.0 1.1 8.5 0.0 2.1 2 0 0 2 2 2 0 Zeta toxin FHA PF00498.26 EXF83833.1 - 4.9e-18 65.2 0.1 1.5e-17 63.6 0.1 1.9 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 EXF83833.1 - 0.00036 20.8 0.0 0.00092 19.5 0.0 1.7 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain YhfZ_C PF14503.6 EXF83833.1 - 0.14 11.7 0.0 0.14 11.7 0.0 1.5 2 0 0 2 2 2 0 YhfZ C-terminal domain GAS PF13851.6 EXF83833.1 - 0.43 9.9 12.6 0.086 12.2 3.1 2.4 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding DUF4047 PF13256.6 EXF83833.1 - 0.64 10.2 3.4 0.26 11.5 0.6 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4047) Csm1_N PF18504.1 EXF83833.1 - 5.1 7.5 7.9 1.1 9.6 1.0 2.8 2 0 0 2 2 2 0 Csm1 N-terminal domain Romo1 PF10247.9 EXF83834.1 - 5.2e-27 94.0 16.2 9.2e-27 93.2 16.2 1.4 1 0 0 1 1 1 1 Reactive mitochondrial oxygen species modulator 1 Tim17 PF02466.19 EXF83834.1 - 0.016 15.6 4.2 0.021 15.2 4.2 1.2 1 0 0 1 1 1 0 Tim17/Tim22/Tim23/Pmp24 family GMC_oxred_N PF00732.19 EXF83835.1 - 4e-60 203.7 0.0 2.9e-58 197.6 0.0 2.2 1 1 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EXF83835.1 - 9.4e-34 117.0 0.0 1.6e-33 116.2 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase NAD_binding_8 PF13450.6 EXF83835.1 - 2.3e-05 24.5 0.1 5.5e-05 23.3 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EXF83835.1 - 5.7e-05 22.5 0.2 0.013 14.8 0.1 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EXF83835.1 - 6.5e-05 22.7 3.9 0.00045 19.9 3.9 2.1 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EXF83835.1 - 0.00013 21.3 0.2 0.052 12.8 0.1 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EXF83835.1 - 0.00014 21.1 3.2 0.0036 16.4 3.1 2.2 1 1 0 1 1 1 1 FAD binding domain Lycopene_cycl PF05834.12 EXF83835.1 - 0.00025 20.2 0.1 0.00036 19.7 0.1 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein Thi4 PF01946.17 EXF83835.1 - 0.00033 20.0 0.3 0.00074 18.8 0.1 1.6 2 0 0 2 2 2 1 Thi4 family HI0933_like PF03486.14 EXF83835.1 - 0.0051 15.6 0.1 0.057 12.1 0.0 2.0 2 0 0 2 2 2 1 HI0933-like protein TrkA_N PF02254.18 EXF83835.1 - 0.053 13.8 0.0 0.18 12.0 0.0 1.9 2 0 0 2 2 2 0 TrkA-N domain Trp_halogenase PF04820.14 EXF83835.1 - 0.22 10.4 0.3 0.33 9.8 0.3 1.2 1 0 0 1 1 1 0 Tryptophan halogenase Asp PF00026.23 EXF83836.1 - 4.7e-49 167.5 0.2 6.7e-49 167.0 0.2 1.2 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EXF83836.1 - 2.3e-07 31.2 1.4 4.8e-06 26.9 1.4 2.6 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal MFS_1 PF07690.16 EXF83837.1 - 3e-35 121.8 12.9 7.9e-27 94.1 6.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily 7TM-7TMR_HD PF07698.11 EXF83837.1 - 0.13 12.0 6.5 1.2 8.8 0.3 2.7 2 0 0 2 2 2 0 7TM receptor with intracellular HD hydrolase MFS_1_like PF12832.7 EXF83837.1 - 0.39 9.5 9.1 0.0078 15.1 2.1 1.7 2 0 0 2 2 2 0 MFS_1 like family VIT1 PF01988.19 EXF83837.1 - 8.3 6.2 7.3 0.88 9.4 0.1 2.6 2 1 0 3 3 3 0 VIT family Fungal_trans_2 PF11951.8 EXF83838.1 - 2.9e-41 141.6 0.0 3.7e-41 141.2 0.0 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Abhydrolase_1 PF00561.20 EXF83839.1 - 3.1e-11 43.4 0.0 9.2e-11 41.9 0.0 1.7 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EXF83839.1 - 1.4e-08 34.3 0.0 2.1e-08 33.8 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EXF83839.1 - 2.8e-06 28.1 1.8 1.1e-05 26.1 1.8 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Ndr PF03096.14 EXF83839.1 - 0.0021 16.8 0.0 0.0031 16.3 0.0 1.3 1 0 0 1 1 1 1 Ndr family Sugarporin_N PF11471.8 EXF83839.1 - 0.019 14.9 0.4 0.047 13.7 0.4 1.6 1 0 0 1 1 1 0 Maltoporin periplasmic N-terminal extension Peptidase_S15 PF02129.18 EXF83839.1 - 0.042 13.4 1.0 0.28 10.7 0.0 2.4 2 1 1 3 3 3 0 X-Pro dipeptidyl-peptidase (S15 family) Creatinase_N PF01321.18 EXF83839.1 - 0.16 12.6 0.0 10 6.8 0.0 2.4 2 0 0 2 2 2 0 Creatinase/Prolidase N-terminal domain Fungal_trans PF04082.18 EXF83840.1 - 2.1e-11 43.4 0.0 3.6e-11 42.6 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain tRNA-synt_2_TM PF16995.5 EXF83840.1 - 0.056 13.1 0.3 2.5 7.7 0.0 2.2 2 0 0 2 2 2 0 Transmembrane region of lysyl-tRNA synthetase Nnf1 PF03980.14 EXF83840.1 - 0.082 13.3 0.1 0.29 11.5 0.0 1.9 2 0 0 2 2 2 0 Nnf1 PhoU PF01895.19 EXF83840.1 - 0.12 12.9 0.1 0.34 11.4 0.1 1.7 1 0 0 1 1 1 0 PhoU domain DUF2508 PF10704.9 EXF83840.1 - 0.2 11.9 0.3 13 6.0 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2508) ABC2_membrane PF01061.24 EXF83841.1 - 5.7e-85 284.0 53.2 6.2e-47 159.7 24.5 2.4 2 0 0 2 2 2 2 ABC-2 type transporter ABC_tran PF00005.27 EXF83841.1 - 9.5e-40 136.3 0.0 9e-19 68.3 0.0 2.5 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.12 EXF83841.1 - 3.8e-28 97.2 9.4 3.4e-26 90.9 0.0 3.7 3 0 0 3 3 3 2 CDR ABC transporter ABC2_membrane_3 PF12698.7 EXF83841.1 - 1.1e-11 44.4 37.6 7.9e-08 31.8 15.2 2.4 2 0 0 2 2 2 2 ABC-2 family transporter protein ABC_trans_N PF14510.6 EXF83841.1 - 5.3e-09 36.6 0.0 5.3e-09 36.6 0.0 2.3 3 0 0 3 3 1 1 ABC-transporter N-terminal AAA_16 PF13191.6 EXF83841.1 - 1.5e-06 28.7 0.1 0.0072 16.7 0.0 2.4 2 0 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 EXF83841.1 - 3.8e-05 23.7 0.1 0.0056 16.6 0.1 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_25 PF13481.6 EXF83841.1 - 0.00011 21.8 0.1 0.0071 15.9 0.1 2.4 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EXF83841.1 - 0.00024 21.3 0.1 1.2 9.3 0.0 2.9 3 0 0 3 3 3 2 AAA domain AAA_22 PF13401.6 EXF83841.1 - 0.00035 20.9 0.1 0.71 10.1 0.1 3.0 2 1 0 2 2 2 2 AAA domain AAA_29 PF13555.6 EXF83841.1 - 0.00041 20.0 0.3 0.087 12.6 0.1 2.7 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_28 PF13521.6 EXF83841.1 - 0.00064 20.0 0.4 0.81 9.9 0.1 2.4 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 EXF83841.1 - 0.0027 18.3 0.0 3.2 8.3 0.0 2.7 2 0 0 2 2 2 2 AAA domain cobW PF02492.19 EXF83841.1 - 0.0031 17.1 1.1 1.4 8.5 0.2 2.3 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.12 EXF83841.1 - 0.044 13.7 0.4 4.2 7.3 0.2 2.4 2 0 0 2 2 2 0 NACHT domain Zeta_toxin PF06414.12 EXF83841.1 - 0.063 12.5 0.1 2.4 7.4 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin MMR_HSR1 PF01926.23 EXF83841.1 - 0.065 13.3 0.1 15 5.7 0.0 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_30 PF13604.6 EXF83841.1 - 0.074 12.8 0.7 6.3 6.5 0.3 2.5 2 0 0 2 2 2 0 AAA domain T2SSE PF00437.20 EXF83841.1 - 0.093 11.8 0.0 2.9 6.9 0.0 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein DnaB_C PF03796.15 EXF83841.1 - 0.14 11.5 0.0 0.96 8.7 0.0 2.0 2 0 0 2 2 2 0 DnaB-like helicase C terminal domain PduV-EutP PF10662.9 EXF83841.1 - 0.21 11.3 0.4 8.1 6.2 0.1 2.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation RbsD_FucU PF05025.13 EXF83842.1 - 1.5e-35 122.5 0.0 1.7e-35 122.4 0.0 1.0 1 0 0 1 1 1 1 RbsD / FucU transport protein family AA_permease PF00324.21 EXF83844.1 - 8.4e-137 456.6 34.6 9.5e-137 456.5 34.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EXF83844.1 - 3.3e-36 125.0 37.9 4.4e-36 124.6 37.9 1.1 1 0 0 1 1 1 1 Amino acid permease Methyltransf_2 PF00891.18 EXF83845.1 - 8.5e-22 77.5 0.0 2.7e-21 75.8 0.0 1.7 1 1 0 1 1 1 1 O-methyltransferase domain partial_CstF PF15861.5 EXF83845.1 - 0.11 12.3 0.0 0.19 11.5 0.0 1.4 1 0 0 1 1 1 0 Partial cleavage stimulation factor domain MFS_1 PF07690.16 EXF83846.1 - 1.5e-36 126.1 50.9 1.6e-36 126.0 46.6 2.7 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EXF83846.1 - 5.8e-10 38.2 15.9 8e-10 37.8 15.9 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EXF83846.1 - 1.7e-06 27.2 6.2 1.7e-06 27.2 6.2 2.6 2 1 0 2 2 2 1 Sugar (and other) transporter OATP PF03137.20 EXF83846.1 - 0.00027 19.4 1.2 0.00027 19.4 1.2 2.8 3 0 0 3 3 3 1 Organic Anion Transporter Polypeptide (OATP) family Med26_M PF15694.5 EXF83846.1 - 0.027 14.5 1.9 0.039 14.0 1.9 1.1 1 0 0 1 1 1 0 Mediator complex subunit 26 middle domain EBP PF05241.12 EXF83847.1 - 4.3e-59 198.9 7.5 5.2e-59 198.7 7.5 1.0 1 0 0 1 1 1 1 Emopamil binding protein Asparaginase PF00710.20 EXF83848.1 - 1e-52 178.5 0.1 1.9e-52 177.6 0.1 1.4 1 0 0 1 1 1 1 Asparaginase, N-terminal Asparaginase_C PF17763.1 EXF83848.1 - 4.1e-19 68.9 0.2 1.5e-18 67.1 0.0 2.0 3 0 0 3 3 3 1 Glutaminase/Asparaginase C-terminal domain Hce2 PF14856.6 EXF83849.1 - 1.1e-24 86.7 0.7 5.3e-08 33.1 0.4 3.4 3 0 0 3 3 3 3 Pathogen effector; putative necrosis-inducing factor PQ-loop PF04193.14 EXF83850.1 - 6e-05 22.7 0.1 6e-05 22.7 0.1 2.9 3 0 0 3 3 3 1 PQ loop repeat ER_lumen_recept PF00810.18 EXF83850.1 - 0.1 13.4 2.9 0.23 12.3 0.1 2.4 2 1 1 3 3 3 0 ER lumen protein retaining receptor DUF4014 PF13198.6 EXF83850.1 - 0.26 11.7 0.0 0.26 11.7 0.0 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF4014) PIG-Y PF15159.6 EXF83850.1 - 0.92 10.5 9.4 0.11 13.4 2.5 2.5 3 0 0 3 3 3 0 Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y PRA1 PF03208.19 EXF83850.1 - 3.9 7.1 8.1 0.11 12.1 1.0 2.0 2 1 0 2 2 2 0 PRA1 family protein Peptidase_M28 PF04389.17 EXF83851.1 - 2.9e-30 105.4 0.0 3.9e-30 105.0 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 EXF83851.1 - 6.1e-06 26.1 0.5 4.3e-05 23.3 0.5 2.1 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 2OG-FeII_Oxy PF03171.20 EXF83855.1 - 1.3e-12 48.1 0.0 2.3e-12 47.3 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 EXF83855.1 - 3e-09 37.6 0.0 5.7e-09 36.7 0.0 1.4 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal Amidohydro_3 PF07969.11 EXF83856.1 - 1.3e-14 54.5 3.4 4e-11 43.1 0.1 3.3 3 0 0 3 3 3 2 Amidohydrolase family Amidohydro_1 PF01979.20 EXF83856.1 - 4e-11 42.8 0.3 2e-10 40.6 0.0 2.3 2 1 0 2 2 2 1 Amidohydrolase family PHD_2 PF13831.6 EXF83856.1 - 0.13 11.8 0.5 0.29 10.7 0.5 1.5 1 0 0 1 1 1 0 PHD-finger Glyco_hydro_20 PF00728.22 EXF83857.1 - 1.1e-25 90.8 0.3 7.7e-23 81.4 0.3 2.5 1 1 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glyco_hydro_20b PF02838.15 EXF83857.1 - 5.4e-08 33.7 0.0 1.1e-07 32.7 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, domain 2 DUF4121 PF13497.6 EXF83857.1 - 0.025 13.7 0.0 0.041 13.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4121) Ferric_reduct PF01794.19 EXF83858.1 - 7.4e-22 77.8 13.3 7.4e-22 77.8 13.3 2.6 3 1 0 3 3 3 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 EXF83858.1 - 3.8e-13 49.5 0.0 6.5e-13 48.7 0.0 1.4 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.12 EXF83858.1 - 3.1e-10 40.4 0.0 5.2e-10 39.7 0.0 1.4 1 0 0 1 1 1 1 Ferric reductase NAD binding domain DUF4405 PF14358.6 EXF83858.1 - 0.57 10.8 19.5 0.11 13.1 3.8 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4405) Ctr PF04145.15 EXF83859.1 - 1.4e-27 97.2 0.1 1.8e-27 96.8 0.1 1.2 1 0 0 1 1 1 1 Ctr copper transporter family DUF3433 PF11915.8 EXF83860.1 - 1.7e-35 121.4 6.9 7.7e-19 68.0 1.4 4.4 6 0 0 6 6 6 2 Protein of unknown function (DUF3433) Fasciclin PF02469.22 EXF83861.1 - 8.4e-41 139.2 0.1 2.3e-20 73.1 0.0 2.2 2 0 0 2 2 2 2 Fasciclin domain Cellulase PF00150.18 EXF83861.1 - 0.018 14.5 0.0 0.028 13.9 0.0 1.3 1 0 0 1 1 1 0 Cellulase (glycosyl hydrolase family 5) DUF719 PF05334.13 EXF83861.1 - 0.13 12.4 0.0 1.6 8.9 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF719) HAD_2 PF13419.6 EXF83861.1 - 0.19 11.8 2.6 0.36 10.9 0.7 2.2 1 1 1 2 2 2 0 Haloacid dehalogenase-like hydrolase GMC_oxred_C PF05199.13 EXF83862.1 - 1.9e-06 28.4 0.0 6e-06 26.8 0.0 1.9 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_N PF00732.19 EXF83862.1 - 1.7e-05 24.3 0.1 0.002 17.6 0.0 2.6 3 0 0 3 3 3 1 GMC oxidoreductase FAD_binding_2 PF00890.24 EXF83862.1 - 8.1e-05 21.9 0.1 0.00014 21.1 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EXF83862.1 - 0.00038 19.8 0.2 0.00067 19.0 0.2 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EXF83862.1 - 0.00044 19.7 0.2 0.00068 19.1 0.2 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EXF83862.1 - 0.0041 17.3 0.1 0.024 14.9 0.1 2.4 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 EXF83862.1 - 0.028 15.0 0.0 0.087 13.4 0.0 1.9 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EXF83862.1 - 0.033 12.9 0.1 0.051 12.3 0.1 1.2 1 0 0 1 1 1 0 HI0933-like protein GIDA PF01134.22 EXF83862.1 - 0.042 12.9 0.1 0.073 12.1 0.1 1.4 1 0 0 1 1 1 0 Glucose inhibited division protein A Smoothelin PF12510.8 EXF83862.1 - 0.064 13.3 0.5 0.11 12.6 0.5 1.3 1 0 0 1 1 1 0 Smoothelin cytoskeleton protein DAO PF01266.24 EXF83862.1 - 0.083 12.5 0.0 0.21 11.1 0.0 1.7 1 0 0 1 1 1 0 FAD dependent oxidoreductase CC190 PF15768.5 EXF83864.1 - 0.01 15.9 11.1 0.012 15.7 11.1 1.0 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 190 PI-PLC-C1 PF16670.5 EXF83864.1 - 0.012 14.7 3.1 0.016 14.3 3.1 1.1 1 0 0 1 1 1 0 Phosphoinositide phospholipase C, Ca2+-dependent AAR2 PF05282.11 EXF83864.1 - 0.27 10.6 4.9 0.32 10.3 4.9 1.1 1 0 0 1 1 1 0 AAR2 protein CobT PF06213.12 EXF83864.1 - 0.31 10.4 17.9 0.47 9.8 17.9 1.4 1 1 0 1 1 1 0 Cobalamin biosynthesis protein CobT FAD-oxidase_C PF02913.19 EXF83864.1 - 0.45 10.1 2.5 0.58 9.7 2.5 1.1 1 0 0 1 1 1 0 FAD linked oxidases, C-terminal domain DUF4407 PF14362.6 EXF83864.1 - 0.52 9.6 5.1 0.61 9.4 5.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Spt20 PF12090.8 EXF83864.1 - 1.2 8.7 11.6 1.5 8.3 11.6 1.2 1 0 0 1 1 1 0 Spt20 family Serglycin PF04360.12 EXF83864.1 - 1.7 8.6 9.2 2.7 7.9 9.2 1.5 1 1 0 1 1 1 0 Serglycin GREB1 PF15782.5 EXF83864.1 - 8.3 3.4 8.3 8.9 3.3 8.3 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer MmgE_PrpD PF03972.14 EXF83865.1 - 1.8e-121 405.8 4.6 2.2e-121 405.5 4.6 1.0 1 0 0 1 1 1 1 MmgE/PrpD family 3Beta_HSD PF01073.19 EXF83867.1 - 2.2e-07 30.2 0.0 4.1e-07 29.3 0.0 1.3 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EXF83867.1 - 9.1e-05 22.0 0.0 0.00015 21.3 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 EXF83867.1 - 0.00015 21.0 0.0 0.00025 20.3 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.6 EXF83867.1 - 0.015 15.2 0.0 0.023 14.6 0.0 1.3 1 0 0 1 1 1 0 NAD(P)H-binding Glyco_hydro_61 PF03443.14 EXF83868.1 - 6.2e-58 196.1 0.0 7.6e-58 195.8 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 Dehydratase_hem PF13816.6 EXF83870.1 - 3.4e-89 299.3 0.0 4e-89 299.1 0.0 1.0 1 0 0 1 1 1 1 Haem-containing dehydratase DUF1330 PF07045.11 EXF83870.1 - 0.07 13.5 0.0 0.17 12.2 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1330) adh_short PF00106.25 EXF83872.1 - 1.5e-33 116.0 0.0 1.8e-33 115.6 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF83872.1 - 7.6e-23 81.3 0.0 1.4e-22 80.5 0.0 1.4 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF83872.1 - 3e-08 33.8 0.1 4.8e-08 33.1 0.1 1.2 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 EXF83872.1 - 0.00087 19.2 0.0 0.0015 18.5 0.0 1.5 1 1 0 1 1 1 1 NAD(P)H-binding RmlD_sub_bind PF04321.17 EXF83872.1 - 0.027 13.6 0.0 0.042 13.0 0.0 1.3 1 0 0 1 1 1 0 RmlD substrate binding domain Epimerase PF01370.21 EXF83872.1 - 0.065 12.7 0.1 0.38 10.2 0.1 2.1 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Nop PF01798.18 EXF83872.1 - 0.18 11.3 0.0 0.53 9.7 0.0 1.7 2 0 0 2 2 2 0 snoRNA binding domain, fibrillarin Pkinase PF00069.25 EXF83873.1 - 1.3e-21 77.2 0.0 1.7e-16 60.4 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EXF83873.1 - 0.0067 15.7 0.0 0.022 14.1 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase AltA1 PF16541.5 EXF83874.1 - 4.9e-26 91.7 1.2 6.4e-26 91.4 1.2 1.1 1 0 0 1 1 1 1 Alternaria alternata allergen 1 XAP5 PF04921.14 EXF83876.1 - 1.7e-96 322.9 0.1 2.3e-96 322.4 0.1 1.2 1 0 0 1 1 1 1 XAP5, circadian clock regulator DUF4604 PF15377.6 EXF83876.1 - 7e-05 23.3 3.9 7e-05 23.3 3.9 2.3 1 1 1 2 2 2 1 Domain of unknown function (DUF4604) ORC6 PF05460.13 EXF83876.1 - 0.06 12.6 4.1 0.08 12.2 4.1 1.2 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Peptidase_M13_N PF05649.13 EXF83877.1 - 0.046 13.4 0.0 0.054 13.2 0.0 1.1 1 0 0 1 1 1 0 Peptidase family M13 CDC50 PF03381.15 EXF83877.1 - 0.18 11.3 0.0 0.24 10.8 0.0 1.1 1 0 0 1 1 1 0 LEM3 (ligand-effect modulator 3) family / CDC50 family Methyltransf_10 PF05971.12 EXF83878.1 - 2e-63 214.5 0.0 2.7e-63 214.1 0.0 1.1 1 0 0 1 1 1 1 RNA methyltransferase MTS PF05175.14 EXF83878.1 - 1.1e-05 25.0 0.0 1.9e-05 24.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 EXF83878.1 - 0.00031 20.2 0.0 0.00082 18.9 0.0 1.6 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_18 PF12847.7 EXF83878.1 - 0.0074 16.2 0.0 0.014 15.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.18 EXF83878.1 - 0.06 13.0 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 Met_10 PF02475.16 EXF83878.1 - 0.24 11.1 0.0 0.42 10.3 0.0 1.3 1 0 0 1 1 1 0 Met-10+ like-protein NAD_binding_10 PF13460.6 EXF83879.1 - 9.2e-17 61.5 0.0 2e-16 60.4 0.0 1.6 1 1 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EXF83879.1 - 4.8e-15 55.7 0.0 6.4e-15 55.3 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family Epimerase PF01370.21 EXF83879.1 - 3.9e-05 23.2 0.1 0.00023 20.7 0.0 1.9 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family KR PF08659.10 EXF83879.1 - 8.8e-05 22.5 0.1 0.00024 21.1 0.0 1.7 2 0 0 2 2 2 1 KR domain 3Beta_HSD PF01073.19 EXF83879.1 - 0.00077 18.6 0.0 0.0012 18.0 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family DapB_N PF01113.20 EXF83879.1 - 0.001 19.2 0.1 0.29 11.3 0.0 2.7 3 0 0 3 3 3 1 Dihydrodipicolinate reductase, N-terminus F420_oxidored PF03807.17 EXF83879.1 - 0.0012 19.4 0.5 0.0031 18.1 0.0 2.0 3 0 0 3 3 3 1 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.20 EXF83879.1 - 0.0017 18.5 0.0 0.0034 17.5 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Sacchrp_dh_NADP PF03435.18 EXF83879.1 - 0.0091 16.3 0.0 0.017 15.4 0.0 1.5 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Zn_clus PF00172.18 EXF83880.1 - 3.3e-05 23.9 9.8 6.5e-05 23.0 9.8 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EXF83880.1 - 0.0017 17.5 0.0 0.0029 16.7 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Cellulase PF00150.18 EXF83882.1 - 3.9e-16 59.3 0.8 5.7e-16 58.8 0.8 1.2 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Ank_3 PF13606.6 EXF83883.1 - 6.5e-12 44.5 0.1 0.013 16.0 0.0 4.1 4 0 0 4 4 4 3 Ankyrin repeat Ank_2 PF12796.7 EXF83883.1 - 2.5e-11 44.0 0.0 2.9e-10 40.6 0.0 2.7 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank PF00023.30 EXF83883.1 - 1.1e-09 38.3 0.8 0.0016 18.8 0.0 4.1 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 EXF83883.1 - 2.4e-07 30.9 0.1 0.0018 18.5 0.0 2.8 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 EXF83883.1 - 1.8e-05 25.2 0.0 0.00088 19.8 0.0 3.4 3 1 1 4 4 4 2 Ankyrin repeats (many copies) AAA_16 PF13191.6 EXF83883.1 - 0.0022 18.4 0.3 0.022 15.1 0.1 2.9 2 1 0 2 2 2 1 AAA ATPase domain NACHT PF05729.12 EXF83883.1 - 0.0023 17.9 0.1 0.0042 17.0 0.1 1.5 1 0 0 1 1 1 1 NACHT domain Torsin PF06309.11 EXF83883.1 - 0.048 13.8 0.0 0.12 12.5 0.0 1.6 1 0 0 1 1 1 0 Torsin RVT_1 PF00078.27 EXF83885.1 - 1.2e-34 119.8 0.0 2e-34 119.1 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 EXF83885.1 - 8.9e-11 41.7 0.0 2e-10 40.6 0.0 1.6 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase DUF4690 PF15756.5 EXF83887.1 - 0.02 15.5 2.4 0.043 14.4 2.4 1.5 1 0 0 1 1 1 0 Small Novel Rich in Cartilage GATase_4 PF13230.6 EXF83888.1 - 1.6e-08 33.8 0.1 2.1e-06 26.8 0.0 2.5 2 1 0 2 2 2 2 Glutamine amidotransferases class-II GATase_6 PF13522.6 EXF83888.1 - 5.9e-07 29.8 0.0 1e-06 28.9 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain Pex14_N PF04695.13 EXF83889.1 - 0.00012 22.7 1.2 0.00012 22.7 1.2 2.1 1 1 1 2 2 2 1 Peroxisomal membrane anchor protein (Pex14p) conserved region PAN_4 PF14295.6 EXF83889.1 - 0.033 14.1 1.7 0.28 11.1 1.7 2.3 1 1 0 1 1 1 0 PAN domain PAN_1 PF00024.26 EXF83889.1 - 2 8.5 6.1 0.17 11.8 0.7 1.9 2 0 0 2 2 2 0 PAN domain Acetyltransf_3 PF13302.7 EXF83890.1 - 3.5e-24 86.1 0.0 4.1e-24 85.8 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EXF83890.1 - 0.0026 18.0 0.0 0.2 11.9 0.0 2.1 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family zf-C2H2_4 PF13894.6 EXF83891.1 - 2.3e-05 24.8 13.8 0.0093 16.7 1.0 3.6 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2 PF00096.26 EXF83891.1 - 4.4e-05 23.7 12.9 0.001 19.4 1.7 3.6 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EXF83891.1 - 1.5 9.4 8.7 2.4 8.7 0.6 3.4 3 0 0 3 3 3 0 Zinc-finger double domain zf-C2H2_aberr PF17017.5 EXF83891.1 - 2.4 8.3 7.4 0.22 11.6 0.4 2.4 2 1 1 3 3 3 0 Aberrant zinc-finger DUF4139 PF13598.6 EXF83892.1 - 9.1e-40 136.6 2.2 2e-39 135.5 2.2 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4139) DUF4140 PF13600.6 EXF83892.1 - 1.5e-26 92.7 0.7 1.5e-26 92.7 0.7 3.9 3 1 0 3 3 3 1 N-terminal domain of unknown function (DUF4140) UDPG_MGDP_dh_N PF03721.14 EXF83893.1 - 1.7e-49 168.0 0.0 2.8e-31 108.6 0.0 2.3 2 0 0 2 2 2 2 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh PF00984.19 EXF83893.1 - 5.8e-32 109.8 0.0 1.9e-31 108.1 0.0 2.0 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain UDPG_MGDP_dh_C PF03720.15 EXF83893.1 - 6.8e-18 65.0 0.0 8.3e-17 61.5 0.0 2.4 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain Sacchrp_dh_NADP PF03435.18 EXF83893.1 - 0.0076 16.5 0.0 0.019 15.2 0.0 1.7 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_2 PF03446.15 EXF83893.1 - 0.017 15.3 0.0 1.1 9.4 0.0 2.7 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase 3HCDH_N PF02737.18 EXF83893.1 - 0.11 12.4 0.0 0.34 10.8 0.0 1.8 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Glycos_transf_1 PF00534.20 EXF83894.1 - 5.2e-35 120.5 0.0 9e-35 119.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EXF83894.1 - 2.2e-28 99.3 0.0 3.7e-28 98.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 EXF83894.1 - 2.3e-17 63.9 0.7 3.9e-17 63.2 0.2 1.7 2 0 0 2 2 2 1 Glycosyl transferase 4-like domain Glyco_transf_4 PF13439.6 EXF83894.1 - 6.6e-14 52.3 0.0 2.5e-12 47.1 0.0 2.2 2 0 0 2 2 2 1 Glycosyltransferase Family 4 Glyco_trans_1_2 PF13524.6 EXF83894.1 - 1.9e-11 44.2 0.0 4.9e-11 42.9 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferases group 1 Fungal_trans PF04082.18 EXF83897.1 - 1.8e-25 89.5 0.5 2.6e-25 88.9 0.5 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF83897.1 - 9.4e-06 25.7 6.7 1.5e-05 25.0 6.7 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Phage_Coat_Gp8 PF05371.12 EXF83897.1 - 0.14 12.0 0.0 0.27 11.0 0.0 1.5 1 0 0 1 1 1 0 Phage major coat protein, Gp8 ECH_1 PF00378.20 EXF83898.1 - 1.6e-46 158.7 0.0 2e-46 158.4 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EXF83898.1 - 6.5e-22 78.5 0.0 9.4e-22 77.9 0.0 1.3 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase p450 PF00067.22 EXF83899.1 - 2.2e-72 244.3 0.0 3e-72 243.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 FAD_binding_1 PF00667.20 EXF83899.1 - 1.9e-33 115.9 0.0 3.5e-33 115.0 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 EXF83899.1 - 1.5e-24 86.8 0.0 3.4e-24 85.7 0.0 1.6 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 EXF83899.1 - 9.1e-13 48.8 0.0 2.5e-12 47.4 0.0 1.8 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Rx_N PF18052.1 EXF83899.1 - 0.025 14.8 0.3 0.072 13.4 0.3 1.8 1 0 0 1 1 1 0 Rx N-terminal domain FAD_binding_6 PF00970.24 EXF83899.1 - 0.14 12.6 0.0 0.51 10.7 0.0 1.9 2 0 0 2 2 2 0 Oxidoreductase FAD-binding domain AMP-binding PF00501.28 EXF83900.1 - 1.1e-35 123.1 0.0 1.7e-35 122.5 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme NAD_binding_4 PF07993.12 EXF83900.1 - 6e-32 110.8 0.0 9.3e-32 110.2 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein Epimerase PF01370.21 EXF83900.1 - 5.4e-07 29.3 0.0 1e-06 28.4 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family PP-binding PF00550.25 EXF83900.1 - 1e-05 25.8 0.0 5.5e-05 23.4 0.0 2.3 2 1 0 2 2 2 1 Phosphopantetheine attachment site Cu-oxidase_2 PF07731.14 EXF83901.1 - 1.2e-45 154.6 10.3 4e-43 146.4 1.6 3.8 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase_3 PF07732.15 EXF83901.1 - 1e-39 135.2 16.5 1.1e-39 135.1 2.8 3.9 5 0 0 5 5 5 2 Multicopper oxidase Cu-oxidase PF00394.22 EXF83901.1 - 2.8e-34 118.6 2.3 2.5e-33 115.4 0.3 2.8 3 0 0 3 3 3 1 Multicopper oxidase MIOX PF05153.15 EXF83902.1 - 1.1e-121 405.2 0.1 1.1e-121 405.2 0.1 1.3 2 0 0 2 2 2 1 Myo-inositol oxygenase HD PF01966.22 EXF83902.1 - 0.004 17.4 0.0 0.61 10.3 0.0 2.4 2 0 0 2 2 2 2 HD domain Peptidase_A6 PF01829.16 EXF83902.1 - 0.043 13.1 0.0 0.062 12.6 0.0 1.1 1 0 0 1 1 1 0 Peptidase A6 family Fungal_trans_2 PF11951.8 EXF83903.1 - 6e-07 28.6 0.2 1.3e-06 27.5 0.1 1.5 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF83903.1 - 3.1e-05 24.0 7.6 5.9e-05 23.1 7.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Sugar_tr PF00083.24 EXF83904.1 - 1.4e-86 291.2 18.3 1.7e-86 290.9 18.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF83904.1 - 1.5e-16 60.3 20.1 3e-14 52.7 17.5 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 EXF83904.1 - 2.7e-05 23.2 4.8 2.7e-05 23.2 4.8 2.3 2 0 0 2 2 2 1 MFS_1 like family MFS_2 PF13347.6 EXF83904.1 - 0.0012 17.5 2.5 0.0012 17.5 2.5 2.3 2 0 0 2 2 2 1 MFS/sugar transport protein Tetraspanin PF00335.20 EXF83904.1 - 0.013 15.2 0.6 0.013 15.2 0.6 2.0 2 0 0 2 2 2 0 Tetraspanin family Claudin_3 PF06653.11 EXF83904.1 - 0.1 12.5 8.2 0.2 11.6 0.9 2.6 2 0 0 2 2 2 0 Tight junction protein, Claudin-like DUF3226 PF11536.8 EXF83904.1 - 0.13 11.9 0.0 9.1 5.9 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3226) DUF4131 PF13567.6 EXF83904.1 - 0.25 11.0 11.5 18 4.9 4.2 3.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4131) MFS_1 PF07690.16 EXF83905.1 - 4.8e-36 124.4 26.1 4.8e-36 124.4 26.1 1.3 2 0 0 2 2 2 1 Major Facilitator Superfamily SpoVAB PF13782.6 EXF83905.1 - 0.042 14.1 0.4 0.042 14.1 0.4 2.6 2 0 0 2 2 2 0 Stage V sporulation protein AB Fungal_trans PF04082.18 EXF83906.1 - 3.1e-27 95.3 0.0 5.2e-27 94.5 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF83906.1 - 5.5e-08 32.8 9.7 9.6e-08 32.0 9.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Aldo_ket_red PF00248.21 EXF83907.1 - 7.7e-52 176.3 0.0 7.1e-51 173.1 0.0 1.9 1 1 0 1 1 1 1 Aldo/keto reductase family ComX PF05952.12 EXF83907.1 - 0.073 13.0 0.0 0.16 11.9 0.0 1.5 1 0 0 1 1 1 0 Bacillus competence pheromone ComX NAD_binding_4 PF07993.12 EXF83908.1 - 1.2e-41 142.6 0.1 2e-41 141.9 0.1 1.4 1 0 0 1 1 1 1 Male sterility protein AMP-binding PF00501.28 EXF83908.1 - 1.4e-36 126.0 0.0 2.4e-36 125.3 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme Epimerase PF01370.21 EXF83908.1 - 9.5e-12 44.9 0.0 2.3e-11 43.6 0.0 1.6 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family AAA_33 PF13671.6 EXF83908.1 - 4.6e-11 43.1 0.0 1.1e-10 41.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain PP-binding PF00550.25 EXF83908.1 - 2.1e-09 37.6 0.8 6.4e-09 36.0 0.3 2.2 2 0 0 2 2 1 1 Phosphopantetheine attachment site SKI PF01202.22 EXF83908.1 - 2.3e-08 34.3 0.0 4.5e-08 33.4 0.0 1.4 1 0 0 1 1 1 1 Shikimate kinase APS_kinase PF01583.20 EXF83908.1 - 1.6e-06 28.1 0.0 3e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_18 PF13238.6 EXF83908.1 - 2.8e-06 27.9 0.0 8.5e-06 26.3 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 EXF83908.1 - 4.4e-05 23.9 0.0 0.00011 22.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain Cytidylate_kin PF02224.18 EXF83908.1 - 0.00015 21.6 0.9 0.00026 20.8 0.0 1.9 2 0 0 2 2 2 1 Cytidylate kinase AAA_25 PF13481.6 EXF83908.1 - 0.00061 19.4 0.8 0.0025 17.4 0.3 2.2 1 1 1 2 2 2 1 AAA domain KR PF08659.10 EXF83908.1 - 0.00064 19.7 0.4 0.01 15.8 0.2 2.4 2 0 0 2 2 2 1 KR domain AAA_16 PF13191.6 EXF83908.1 - 0.0014 19.0 1.1 0.004 17.5 0.0 2.3 3 0 0 3 3 2 1 AAA ATPase domain AAA PF00004.29 EXF83908.1 - 0.0019 18.6 0.1 0.0063 16.9 0.1 1.9 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.12 EXF83908.1 - 0.003 16.9 0.0 0.0069 15.7 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin B12-binding PF02310.19 EXF83908.1 - 0.0097 15.9 0.1 1.7 8.7 0.0 3.1 2 0 0 2 2 2 1 B12 binding domain AAA_PrkA PF08298.11 EXF83908.1 - 0.021 13.8 0.0 0.043 12.7 0.0 1.4 1 0 0 1 1 1 0 PrkA AAA domain Polysacc_synt_2 PF02719.15 EXF83908.1 - 0.024 13.8 0.0 0.039 13.1 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein ABC_tran PF00005.27 EXF83908.1 - 0.03 14.8 0.0 0.07 13.6 0.0 1.6 1 0 0 1 1 1 0 ABC transporter 3Beta_HSD PF01073.19 EXF83908.1 - 0.03 13.3 0.0 0.085 11.8 0.0 1.7 1 1 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Semialdhyde_dh PF01118.24 EXF83908.1 - 0.032 14.7 0.0 0.082 13.3 0.0 1.7 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain IstB_IS21 PF01695.17 EXF83908.1 - 0.061 13.0 0.0 0.16 11.7 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein Cytidylate_kin2 PF13189.6 EXF83908.1 - 0.073 13.2 0.0 0.16 12.1 0.0 1.6 1 0 0 1 1 1 0 Cytidylate kinase-like family AAA_29 PF13555.6 EXF83908.1 - 0.075 12.8 0.0 0.21 11.3 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain NACHT PF05729.12 EXF83908.1 - 0.082 12.8 0.0 0.24 11.3 0.0 1.8 1 0 0 1 1 1 0 NACHT domain CobU PF02283.16 EXF83908.1 - 0.1 12.2 0.5 2.7 7.5 0.0 2.5 2 0 0 2 2 2 0 Cobinamide kinase / cobinamide phosphate guanyltransferase T2SSE PF00437.20 EXF83908.1 - 0.12 11.4 0.8 0.37 9.8 0.0 2.0 2 0 0 2 2 2 0 Type II/IV secretion system protein PhoH PF02562.16 EXF83908.1 - 0.12 11.8 0.1 0.26 10.7 0.1 1.4 1 0 0 1 1 1 0 PhoH-like protein dNK PF01712.19 EXF83908.1 - 0.14 12.0 0.1 2.1 8.2 0.0 2.2 2 0 0 2 2 2 0 Deoxynucleoside kinase NB-ARC PF00931.22 EXF83908.1 - 0.18 11.0 0.0 0.34 10.0 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain Lactamase_B PF00753.27 EXF83909.1 - 4.3e-09 36.7 0.3 6.4e-09 36.1 0.3 1.3 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EXF83909.1 - 0.0073 15.8 0.1 0.022 14.3 0.1 1.8 1 1 1 2 2 2 1 Beta-lactamase superfamily domain Varsurf_PPLC PF03490.13 EXF83910.1 - 0.016 15.1 0.0 0.058 13.4 0.0 1.9 1 0 0 1 1 1 0 Variant-surface-glycoprotein phospholipase C Macro PF01661.21 EXF83911.1 - 1.1e-25 90.0 0.0 1.9e-25 89.2 0.0 1.4 1 0 0 1 1 1 1 Macro domain Egh16-like PF11327.8 EXF83912.1 - 6.3e-52 176.7 9.7 8.3e-52 176.3 9.7 1.1 1 0 0 1 1 1 1 Egh16-like virulence factor Amino_oxidase PF01593.24 EXF83913.1 - 9.1e-40 137.3 0.2 1.1e-38 133.7 0.2 2.0 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EXF83913.1 - 1.1e-05 25.6 0.0 3.1e-05 24.1 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain YdjM PF04307.14 EXF83913.1 - 0.027 13.8 0.0 0.055 12.8 0.0 1.4 1 0 0 1 1 1 0 LexA-binding, inner membrane-associated putative hydrolase Pkinase PF00069.25 EXF83914.1 - 2.4e-22 79.6 0.0 3.8e-22 78.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF83914.1 - 2.3e-10 40.2 0.0 3.5e-10 39.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EXF83915.1 - 5.3e-17 62.1 0.0 8.4e-17 61.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain DUF4203 PF13886.6 EXF83916.1 - 0.0048 16.6 1.1 0.0077 15.9 1.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4203) CorA PF01544.18 EXF83916.1 - 0.051 12.9 6.7 0.13 11.6 6.7 1.6 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein DUF1823 PF08853.11 EXF83917.1 - 0.08 13.1 0.1 0.32 11.2 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1823) GPR15L PF15854.5 EXF83918.1 - 0.084 13.1 0.5 0.15 12.3 0.1 1.6 2 0 0 2 2 2 0 G-protein coupled receptor ligand 15 DUF3328 PF11807.8 EXF83920.1 - 1.1e-23 84.2 3.2 1.4e-23 83.8 3.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) Plug_translocon PF10559.9 EXF83920.1 - 0.41 10.5 1.5 0.48 10.3 0.2 1.7 2 0 0 2 2 2 0 Plug domain of Sec61p DUF3328 PF11807.8 EXF83921.1 - 8.4e-27 94.4 8.0 3e-26 92.6 8.0 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF3328) SLC3A2_N PF16028.5 EXF83921.1 - 0.13 11.8 0.0 0.55 9.8 0.0 1.9 2 0 0 2 2 2 0 Solute carrier family 3 member 2 N-terminus Fip1 PF05182.13 EXF83922.1 - 9.2e-21 73.1 1.3 2e-20 72.0 1.3 1.5 1 0 0 1 1 1 1 Fip1 motif Nucleoporin_FG PF13634.6 EXF83923.1 - 1.3e-13 51.6 110.2 6e-07 30.2 38.5 4.2 2 1 2 4 4 4 3 Nucleoporin FG repeat region DUF1640 PF07798.11 EXF83923.1 - 0.02 15.0 0.2 0.071 13.2 0.0 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF1640) Prominin PF05478.11 EXF83923.1 - 0.049 11.6 1.3 0.078 10.9 0.4 1.6 2 0 0 2 2 2 0 Prominin Tup_N PF08581.10 EXF83923.1 - 0.053 13.8 1.4 0.21 11.9 0.0 2.4 2 0 0 2 2 2 0 Tup N-terminal SAM_Exu PF18609.1 EXF83923.1 - 0.093 12.8 0.0 0.2 11.8 0.0 1.5 1 0 0 1 1 1 0 Exuperantia SAM-like domain RNA_pol_3_Rpc31 PF11705.8 EXF83924.1 - 2.5e-62 211.1 5.4 3e-62 210.9 5.4 1.0 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 MFS_1 PF07690.16 EXF83925.1 - 8.8e-39 133.4 42.8 8.8e-39 133.4 42.8 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF83925.1 - 2e-09 36.9 29.8 7.8e-09 34.9 29.8 1.9 1 1 0 1 1 1 1 Sugar (and other) transporter PTR2 PF00854.21 EXF83925.1 - 0.025 13.4 0.5 0.025 13.4 0.5 2.7 3 0 0 3 3 3 0 POT family UPF0093 PF03653.13 EXF83925.1 - 0.046 13.9 0.2 0.29 11.3 0.0 2.5 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0093) Prefoldin_2 PF01920.20 EXF83926.1 - 1.6e-26 92.3 10.2 1.6e-26 92.3 10.2 1.4 2 0 0 2 2 2 1 Prefoldin subunit MMTV_SAg PF01054.17 EXF83926.1 - 0.0057 16.2 1.2 1.6 8.2 0.1 2.1 1 1 1 2 2 2 2 Mouse mammary tumour virus superantigen UPF0242 PF06785.11 EXF83926.1 - 0.011 15.9 8.0 0.013 15.6 8.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus PI3K_P85_iSH2 PF16454.5 EXF83926.1 - 0.035 13.7 9.5 0.11 12.1 9.5 1.7 1 1 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Syntaxin-6_N PF09177.11 EXF83926.1 - 0.044 14.3 5.5 1.4 9.5 1.8 2.2 2 0 0 2 2 2 0 Syntaxin 6, N-terminal bZIP_1 PF00170.21 EXF83926.1 - 0.075 13.1 1.2 0.075 13.1 1.2 2.2 2 0 0 2 2 2 0 bZIP transcription factor DUF1664 PF07889.12 EXF83926.1 - 0.14 12.2 0.2 0.14 12.2 0.2 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) XhlA PF10779.9 EXF83926.1 - 0.25 11.5 0.3 0.25 11.5 0.3 2.3 2 0 0 2 2 2 0 Haemolysin XhlA V_ATPase_I PF01496.19 EXF83926.1 - 0.37 8.7 3.9 0.46 8.3 3.9 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family MIT_C PF16565.5 EXF83926.1 - 0.96 9.4 4.6 1.8 8.6 0.2 2.1 1 1 1 2 2 2 0 Phospholipase D-like domain at C-terminus of MIT MtrG PF04210.13 EXF83926.1 - 1.4 8.9 3.4 0.48 10.3 0.2 1.9 2 1 1 3 3 3 0 Tetrahydromethanopterin S-methyltransferase, subunit G Spc24 PF08286.11 EXF83926.1 - 8.8 6.6 13.4 0.69 10.2 1.0 2.2 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 CENP-W PF15510.6 EXF83927.1 - 0.0076 16.4 0.0 0.0089 16.2 0.0 1.2 1 0 0 1 1 1 1 CENP-W protein PRTP PF01366.18 EXF83928.1 - 0.36 8.8 8.0 0.52 8.3 8.0 1.3 1 0 0 1 1 1 0 Herpesvirus processing and transport protein ARGLU PF15346.6 EXF83928.1 - 1.8 8.4 15.7 0.18 11.6 10.8 1.9 2 0 0 2 2 2 0 Arginine and glutamate-rich 1 FUSC PF04632.12 EXF83928.1 - 5.1 5.5 9.9 4.3 5.7 5.9 2.0 1 1 1 2 2 2 0 Fusaric acid resistance protein family FAD_binding_4 PF01565.23 EXF83929.1 - 1e-19 70.7 3.1 1e-19 70.7 3.1 1.9 2 0 0 2 2 2 1 FAD binding domain BBE PF08031.12 EXF83929.1 - 7.4e-14 51.6 1.0 2.1e-13 50.2 1.0 1.8 1 0 0 1 1 1 1 Berberine and berberine like DNA_binding_1 PF01035.20 EXF83930.1 - 8.2e-30 102.8 0.0 1.2e-29 102.3 0.0 1.2 1 0 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, DNA binding domain SO_alpha_A3 PF17806.1 EXF83930.1 - 0.12 12.7 0.0 0.23 11.8 0.0 1.5 1 0 0 1 1 1 0 Sarcosine oxidase A3 domain YukD PF08817.10 EXF83931.1 - 0.00092 19.9 0.0 0.0014 19.3 0.0 1.3 1 0 0 1 1 1 1 WXG100 protein secretion system (Wss), protein YukD ubiquitin PF00240.23 EXF83931.1 - 0.0073 16.0 0.0 0.011 15.4 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin family AAA PF00004.29 EXF83932.1 - 2.8e-50 170.2 0.0 1.2e-37 129.2 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EXF83932.1 - 9.1e-10 38.2 0.1 2.5e-09 36.8 0.1 1.8 1 0 0 1 1 1 1 AAA+ lid domain AAA_22 PF13401.6 EXF83932.1 - 4.6e-08 33.4 0.0 0.00037 20.8 0.0 3.8 2 2 0 2 2 2 1 AAA domain TIP49 PF06068.13 EXF83932.1 - 4.1e-07 29.5 0.0 0.022 14.0 0.0 2.4 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_16 PF13191.6 EXF83932.1 - 7e-07 29.8 0.0 0.04 14.3 0.0 3.0 2 1 0 2 2 2 2 AAA ATPase domain AAA_14 PF13173.6 EXF83932.1 - 1.3e-06 28.5 0.0 0.021 14.8 0.0 2.5 2 0 0 2 2 2 2 AAA domain ATPase_2 PF01637.18 EXF83932.1 - 3.2e-06 27.2 0.1 1.5 8.7 0.0 4.2 2 2 1 4 4 4 1 ATPase domain predominantly from Archaea AAA_2 PF07724.14 EXF83932.1 - 4.2e-06 27.0 0.0 5.5e-05 23.3 0.1 2.5 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 EXF83932.1 - 5e-06 26.6 0.0 0.0022 18.0 0.0 2.7 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 EXF83932.1 - 2.5e-05 23.8 0.1 0.0041 16.5 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 EXF83932.1 - 3.8e-05 24.2 0.0 0.015 15.9 0.0 2.9 3 0 0 3 3 2 1 AAA domain RuvB_N PF05496.12 EXF83932.1 - 7.4e-05 22.5 0.2 0.062 13.0 0.1 2.9 2 1 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_7 PF12775.7 EXF83932.1 - 8.7e-05 22.1 0.1 0.015 14.9 0.0 2.6 3 0 0 3 3 2 1 P-loop containing dynein motor region RNA_helicase PF00910.22 EXF83932.1 - 9.5e-05 22.7 0.0 0.29 11.6 0.0 2.9 2 0 0 2 2 2 2 RNA helicase AAA_24 PF13479.6 EXF83932.1 - 9.5e-05 22.2 0.0 0.033 13.9 0.0 2.7 2 1 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EXF83932.1 - 0.00028 21.1 0.0 0.34 11.1 0.0 2.5 2 0 0 2 2 2 2 AAA domain IstB_IS21 PF01695.17 EXF83932.1 - 0.00029 20.6 0.0 0.038 13.7 0.0 3.3 3 0 0 3 3 3 1 IstB-like ATP binding protein ATPase PF06745.13 EXF83932.1 - 0.003 16.9 0.1 0.13 11.6 0.1 2.6 2 0 0 2 2 2 1 KaiC TsaE PF02367.17 EXF83932.1 - 0.0034 17.4 0.0 0.48 10.4 0.0 2.4 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_25 PF13481.6 EXF83932.1 - 0.006 16.2 0.1 4.1 6.9 0.1 2.8 2 1 0 2 2 2 1 AAA domain Sigma54_activat PF00158.26 EXF83932.1 - 0.0085 15.8 0.0 0.73 9.5 0.0 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain NACHT PF05729.12 EXF83932.1 - 0.0098 15.8 0.4 16 5.4 0.0 3.8 4 1 0 4 4 3 0 NACHT domain ABC_tran PF00005.27 EXF83932.1 - 0.01 16.3 0.1 0.06 13.9 0.1 2.3 2 1 0 2 2 1 0 ABC transporter AAA_19 PF13245.6 EXF83932.1 - 0.011 16.0 0.1 0.42 10.9 0.1 2.8 2 1 0 2 2 2 0 AAA domain AAA_11 PF13086.6 EXF83932.1 - 0.016 15.0 0.0 1.4 8.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain CPT PF07931.12 EXF83932.1 - 0.019 14.8 0.0 0.32 10.8 0.0 2.4 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein NB-ARC PF00931.22 EXF83932.1 - 0.027 13.6 0.1 4.8 6.3 0.1 2.9 3 0 0 3 3 3 0 NB-ARC domain KTI12 PF08433.10 EXF83932.1 - 0.052 13.0 0.0 1.6 8.1 0.0 2.4 2 0 0 2 2 2 0 Chromatin associated protein KTI12 TniB PF05621.11 EXF83932.1 - 0.052 12.9 0.1 6.6 6.1 0.0 3.3 2 1 1 3 3 3 0 Bacterial TniB protein AAA_3 PF07726.11 EXF83932.1 - 0.053 13.4 0.0 0.5 10.2 0.0 2.4 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Parvo_NS1 PF01057.17 EXF83932.1 - 0.059 12.5 0.0 1.6 7.8 0.0 2.2 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 PhoH PF02562.16 EXF83932.1 - 0.073 12.5 0.0 1 8.8 0.0 2.2 2 0 0 2 2 2 0 PhoH-like protein AAA_28 PF13521.6 EXF83932.1 - 0.12 12.6 0.0 0.82 9.9 0.0 2.1 2 0 0 2 2 2 0 AAA domain CDC48_2 PF02933.17 EXF83932.1 - 0.16 11.8 0.7 3.9 7.3 0.1 2.5 2 0 0 2 2 2 0 Cell division protein 48 (CDC48), domain 2 Vps4_C PF09336.10 EXF83932.1 - 0.17 11.9 0.0 0.66 10.0 0.0 2.0 1 0 0 1 1 1 0 Vps4 C terminal oligomerisation domain Cir_N PF10197.9 EXF83933.1 - 8.9e-09 35.4 3.5 8.9e-09 35.4 3.5 2.9 2 0 0 2 2 2 1 N-terminal domain of CBF1 interacting co-repressor CIR FAD_binding_4 PF01565.23 EXF83934.1 - 2e-23 82.7 2.6 3e-23 82.1 1.8 1.7 1 1 0 1 1 1 1 FAD binding domain BBE PF08031.12 EXF83934.1 - 3.9e-07 30.1 0.1 8.2e-07 29.0 0.1 1.5 1 0 0 1 1 1 1 Berberine and berberine like Glyco_transf_28 PF03033.20 EXF83935.1 - 3e-17 62.9 0.0 8.6e-17 61.5 0.0 1.8 1 1 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain UDPGT PF00201.18 EXF83935.1 - 0.0016 17.3 0.0 0.0027 16.6 0.0 1.2 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase VPS13_C PF16909.5 EXF83935.1 - 0.0093 15.8 1.1 0.013 15.3 0.1 1.7 2 0 0 2 2 2 1 Vacuolar-sorting-associated 13 protein C-terminal ATG_C PF09333.11 EXF83935.1 - 0.033 14.5 0.1 0.16 12.3 0.0 2.2 2 0 0 2 2 2 0 Autophagy-related protein C terminal domain Sporozoite_P67 PF05642.11 EXF83935.1 - 0.1 10.6 1.6 0.16 10.1 1.6 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Glyco_tran_28_C PF04101.16 EXF83935.1 - 0.12 12.4 0.0 0.24 11.4 0.0 1.4 1 0 0 1 1 1 0 Glycosyltransferase family 28 C-terminal domain Band_7 PF01145.25 EXF83936.1 - 9.7e-28 97.4 2.7 1.4e-27 96.8 2.7 1.2 1 0 0 1 1 1 1 SPFH domain / Band 7 family Band_7_1 PF13421.6 EXF83936.1 - 0.014 15.1 0.2 0.022 14.5 0.2 1.3 1 0 0 1 1 1 0 SPFH domain-Band 7 family DUF1788 PF08747.11 EXF83936.1 - 0.092 12.8 0.1 0.54 10.3 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1788) KxDL PF10241.9 EXF83939.1 - 1.9e-30 105.0 2.3 2.7e-30 104.5 2.3 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein DUF2385 PF09539.10 EXF83939.1 - 0.0045 17.5 0.6 0.012 16.1 0.6 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF2385) Herpes_capsid PF06112.11 EXF83939.1 - 0.28 11.2 8.0 0.51 10.4 8.0 1.4 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein XylR_N PF06505.11 EXF83939.1 - 0.34 10.7 1.1 0.46 10.3 0.1 1.7 2 0 0 2 2 2 0 Activator of aromatic catabolism DUF883 PF05957.13 EXF83939.1 - 0.89 10.2 5.8 5.7 7.6 1.6 2.2 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) DEAD PF00270.29 EXF83941.1 - 3.3e-37 127.9 0.0 8e-37 126.7 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EXF83941.1 - 1.4e-23 83.4 0.0 4.1e-23 81.9 0.0 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EXF83941.1 - 2e-20 72.8 0.0 3.3e-20 72.1 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 EXF83941.1 - 0.0038 17.3 0.0 0.013 15.5 0.0 1.9 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SprA-related PF12118.8 EXF83941.1 - 6.2 5.9 11.2 9.2 5.3 11.2 1.1 1 0 0 1 1 1 0 SprA-related family Ank_2 PF12796.7 EXF83942.1 - 2.3e-36 124.2 5.3 2.4e-11 44.1 0.0 7.7 5 2 3 8 8 8 6 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EXF83942.1 - 1.1e-25 86.8 7.6 0.0016 18.7 0.0 10.9 11 0 0 11 11 11 7 Ankyrin repeat Ank_4 PF13637.6 EXF83942.1 - 2.8e-20 72.4 7.9 2.3e-05 24.8 0.0 8.1 7 2 5 12 12 12 5 Ankyrin repeats (many copies) Ank PF00023.30 EXF83942.1 - 4e-10 39.7 25.6 0.016 15.6 0.0 10.1 13 0 0 13 13 13 5 Ankyrin repeat Clr5 PF14420.6 EXF83942.1 - 1.3e-09 38.2 1.1 3e-09 37.0 1.1 1.6 1 0 0 1 1 1 1 Clr5 domain Ank_5 PF13857.6 EXF83942.1 - 2e-09 37.5 15.5 0.3 11.5 0.1 10.0 7 2 5 12 12 12 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 EXF83943.1 - 1.4e-26 92.9 0.8 1.1e-08 35.5 0.0 6.2 5 2 1 6 6 6 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EXF83943.1 - 7.8e-17 61.4 0.1 8e-05 23.1 0.0 5.6 3 2 1 5 5 5 3 Ankyrin repeats (many copies) Ank PF00023.30 EXF83943.1 - 2.5e-12 46.7 8.2 0.04 14.4 0.1 7.0 6 0 0 6 6 6 3 Ankyrin repeat Ank_3 PF13606.6 EXF83943.1 - 1.8e-11 43.2 4.2 0.015 15.8 0.1 8.1 8 0 0 8 8 8 2 Ankyrin repeat Ank_5 PF13857.6 EXF83943.1 - 1.7e-08 34.6 3.0 0.011 16.0 0.0 5.5 5 1 1 6 6 6 3 Ankyrin repeats (many copies) Clr5 PF14420.6 EXF83943.1 - 4e-07 30.1 1.3 1.2e-06 28.6 0.6 2.3 2 0 0 2 2 2 1 Clr5 domain DUF3291 PF11695.8 EXF83943.1 - 0.00091 18.9 0.0 0.0023 17.6 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3291) RasGEF PF00617.19 EXF83944.1 - 1.3e-47 162.2 0.5 2.1e-47 161.6 0.5 1.3 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 EXF83944.1 - 5.1e-11 42.7 0.0 1.1e-10 41.7 0.0 1.6 1 0 0 1 1 1 1 RasGEF N-terminal motif Ribosomal_S2 PF00318.20 EXF83945.1 - 5.8e-27 94.3 0.1 4.5e-15 55.5 0.1 2.1 1 1 1 2 2 2 2 Ribosomal protein S2 40S_SA_C PF16122.5 EXF83945.1 - 6.3e-07 30.7 11.9 1.1e-06 29.9 11.9 1.4 1 0 0 1 1 1 1 40S ribosomal protein SA C-terminus Ribosomal_S15 PF00312.22 EXF83946.1 - 1.8e-22 79.3 1.0 7e-22 77.4 0.4 2.2 2 0 0 2 2 2 1 Ribosomal protein S15 vATP-synt_AC39 PF01992.16 EXF83947.1 - 2.1e-102 343.1 0.1 1.2e-93 314.3 0.0 2.0 2 0 0 2 2 2 2 ATP synthase (C/AC39) subunit Nop PF01798.18 EXF83948.1 - 1.3e-76 257.1 0.0 1.3e-76 257.1 0.0 2.3 2 0 0 2 2 2 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 EXF83948.1 - 3.9e-18 65.6 0.5 3.9e-18 65.6 0.5 3.3 3 0 0 3 3 3 1 NOP5NT (NUC127) domain GARS_A PF01071.19 EXF83949.1 - 5.8e-74 248.1 0.0 9.1e-74 247.4 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ANAPC10 PF03256.16 EXF83949.1 - 2.6e-48 164.1 0.2 7.9e-48 162.6 0.0 1.7 2 0 0 2 2 2 1 Anaphase-promoting complex, subunit 10 (APC10) HET PF06985.11 EXF83949.1 - 2.5e-31 109.0 0.0 4.2e-31 108.3 0.0 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) GARS_N PF02844.15 EXF83949.1 - 5.1e-30 104.1 0.0 1e-29 103.1 0.0 1.6 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, N domain GARS_C PF02843.16 EXF83949.1 - 2.1e-28 98.4 0.3 2.6e-27 94.9 0.1 2.6 2 0 0 2 2 2 1 Phosphoribosylglycinamide synthetase, C domain ATP-grasp_3 PF02655.14 EXF83949.1 - 0.027 14.5 0.0 0.087 12.9 0.0 1.8 2 0 0 2 2 2 0 ATP-grasp domain ATP-grasp_4 PF13535.6 EXF83949.1 - 0.22 11.1 0.0 0.42 10.2 0.0 1.4 1 0 0 1 1 1 0 ATP-grasp domain CPSase_L_D2 PF02786.17 EXF83949.1 - 0.23 10.9 0.3 0.52 9.8 0.0 1.7 2 0 0 2 2 2 0 Carbamoyl-phosphate synthase L chain, ATP binding domain NAD_binding_10 PF13460.6 EXF83950.1 - 2.1e-05 24.5 0.0 2.5e-05 24.2 0.0 1.1 1 0 0 1 1 1 1 NAD(P)H-binding MFS_1 PF07690.16 EXF83951.1 - 6.1e-26 91.2 49.2 1e-15 57.5 32.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 EXF83951.1 - 0.0081 15.1 23.2 0.019 13.8 9.4 2.4 1 1 1 2 2 2 2 MFS_1 like family DUF5597 PF18120.1 EXF83952.1 - 2.2e-25 89.3 0.0 3.5e-25 88.7 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF5597) Glyco_hydro_42 PF02449.15 EXF83952.1 - 1e-12 48.1 0.0 1.6e-12 47.5 0.0 1.2 1 0 0 1 1 1 1 Beta-galactosidase Glyco_hydro_35 PF01301.19 EXF83952.1 - 9e-08 32.1 0.0 0.00021 21.0 0.0 2.1 2 0 0 2 2 2 2 Glycosyl hydrolases family 35 Glyco_hydro_10 PF00331.20 EXF83952.1 - 0.2 10.8 0.0 0.31 10.1 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 10 Fungal_trans PF04082.18 EXF83953.1 - 3.9e-13 49.1 1.4 8.8e-13 47.9 1.4 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF83953.1 - 0.00057 19.9 9.9 0.0011 19.0 9.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Sugar_tr PF00083.24 EXF83954.1 - 9.6e-86 288.4 25.7 1.2e-85 288.1 25.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF83954.1 - 1.7e-19 69.9 41.7 4.2e-16 58.8 11.5 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily PTR2 PF00854.21 EXF83954.1 - 0.11 11.3 14.1 0.21 10.4 4.2 2.3 2 0 0 2 2 2 0 POT family HLH PF00010.26 EXF83955.1 - 8.8e-16 57.6 0.1 1.7e-15 56.7 0.1 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain GREB1 PF15782.5 EXF83955.1 - 0.1 9.7 13.4 0.13 9.4 13.4 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SPX PF03105.19 EXF83955.1 - 0.15 11.9 14.7 0.21 11.5 14.7 1.3 1 0 0 1 1 1 0 SPX domain Spt20 PF12090.8 EXF83955.1 - 1.5 8.4 21.7 3.7 7.1 21.7 1.7 1 0 0 1 1 1 0 Spt20 family Presenilin PF01080.17 EXF83955.1 - 2 7.1 12.4 2.3 6.9 12.4 1.2 1 0 0 1 1 1 0 Presenilin Lin-8 PF03353.15 EXF83955.1 - 2.2 7.8 11.8 3.7 7.0 11.8 1.4 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Plasmodium_Vir PF05795.11 EXF83955.1 - 2.4 7.5 6.6 3.7 6.9 6.6 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Peptidase_S64 PF08192.11 EXF83955.1 - 6.8 5.0 11.6 8.4 4.7 11.6 1.1 1 0 0 1 1 1 0 Peptidase family S64 Ndc1_Nup PF09531.10 EXF83955.1 - 8.7 4.9 16.2 11 4.5 16.2 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup p450 PF00067.22 EXF83956.1 - 1e-22 80.5 0.0 1.2e-22 80.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 TauD PF02668.16 EXF83957.1 - 7.3e-45 153.9 0.2 1e-44 153.4 0.2 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family TauD PF02668.16 EXF83958.1 - 8e-31 107.8 0.0 1.1e-30 107.4 0.0 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family CN_hydrolase PF00795.22 EXF83959.1 - 1.7e-34 119.4 0.0 6.1e-34 117.5 0.0 1.8 1 1 0 1 1 1 1 Carbon-nitrogen hydrolase MFS_1 PF07690.16 EXF83960.1 - 2.4e-34 118.8 31.2 3.6e-34 118.2 31.2 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily Methyltransf_2 PF00891.18 EXF83960.1 - 7e-20 71.2 0.0 1.1e-19 70.6 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain Sugar_tr PF00083.24 EXF83960.1 - 8.1e-09 34.8 18.9 2e-08 33.5 18.9 1.5 1 1 0 1 1 1 1 Sugar (and other) transporter Saf_2TM PF18303.1 EXF83960.1 - 0.14 11.7 0.1 2 8.0 0.0 2.4 2 0 0 2 2 2 0 SAVED-fused 2TM effector domain PAN_4 PF14295.6 EXF83961.1 - 1.7e-11 43.8 2.6 2.4e-06 27.4 0.4 2.5 2 0 0 2 2 2 2 PAN domain PAN_1 PF00024.26 EXF83961.1 - 2.6e-09 36.9 2.6 0.00014 21.7 0.2 2.3 2 0 0 2 2 2 2 PAN domain MANEC PF07502.14 EXF83961.1 - 1.6e-06 28.3 0.9 0.051 13.8 0.1 2.3 2 0 0 2 2 2 2 MANEC domain PAN_2 PF08276.11 EXF83961.1 - 0.53 10.4 7.2 2.4 8.3 1.3 2.5 2 1 0 2 2 2 0 PAN-like domain Cu-oxidase_2 PF07731.14 EXF83962.1 - 7.9e-41 139.0 9.2 8.6e-40 135.7 0.7 2.9 2 1 0 2 2 2 2 Multicopper oxidase Cu-oxidase_3 PF07732.15 EXF83962.1 - 3e-37 127.3 3.0 9.3e-37 125.7 3.0 1.9 1 0 0 1 1 1 1 Multicopper oxidase Cu-oxidase PF00394.22 EXF83962.1 - 4.1e-33 114.7 3.4 4e-32 111.5 1.3 2.5 2 0 0 2 2 2 1 Multicopper oxidase MFS18 PF17352.2 EXF83963.1 - 0.019 15.3 2.3 0.019 15.3 2.3 2.3 1 1 1 2 2 2 0 Male Flower Specific protein 18 Clr5 PF14420.6 EXF83965.1 - 2.9e-15 56.2 2.0 6.3e-15 55.1 2.0 1.6 1 0 0 1 1 1 1 Clr5 domain TauD PF02668.16 EXF83966.1 - 2.5e-31 109.5 0.2 4e-31 108.8 0.2 1.3 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family AftA_C PF12249.8 EXF83966.1 - 0.15 11.7 0.1 0.29 10.8 0.1 1.4 1 0 0 1 1 1 0 Arabinofuranosyltransferase A C terminal Peptidase_S10 PF00450.22 EXF83967.1 - 4.1e-85 286.7 1.6 6.1e-85 286.1 1.6 1.2 1 0 0 1 1 1 1 Serine carboxypeptidase Zn_clus PF00172.18 EXF83967.1 - 3.8e-06 26.9 8.4 9.6e-06 25.6 8.4 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Cep3 PF16846.5 EXF83967.1 - 0.07 11.6 0.1 0.11 11.0 0.1 1.1 1 0 0 1 1 1 0 Centromere DNA-binding protein complex CBF3 subunit B DUF3984 PF13136.6 EXF83969.1 - 2.9e-63 214.3 29.3 2.7e-62 211.1 29.3 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF3984) IKI3 PF04762.12 EXF83970.1 - 0 1020.2 0.0 0 1019.7 0.0 1.2 1 0 0 1 1 1 1 IKI3 family ANAPC4_WD40 PF12894.7 EXF83970.1 - 0.0078 16.5 0.9 15 6.0 0.0 4.9 5 1 1 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain Ras PF00071.22 EXF83972.1 - 8.6e-56 188.0 0.0 1e-55 187.8 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EXF83972.1 - 1.3e-21 77.0 0.0 2e-21 76.5 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EXF83972.1 - 8e-07 28.7 0.0 1.3e-06 28.0 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EXF83972.1 - 0.0018 17.7 0.0 0.0026 17.2 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit NB-ARC PF00931.22 EXF83972.1 - 0.1 11.8 0.1 0.8 8.8 0.0 2.0 1 1 1 2 2 2 0 NB-ARC domain Gtr1_RagA PF04670.12 EXF83972.1 - 0.25 10.7 0.0 0.32 10.3 0.0 1.4 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region IMS PF00817.20 EXF83973.1 - 4.4e-37 127.4 0.0 8.3e-37 126.5 0.0 1.5 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.8 EXF83973.1 - 5.8e-11 43.1 0.0 1.1e-10 42.3 0.0 1.4 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.8 EXF83973.1 - 0.0063 16.8 0.0 0.019 15.2 0.0 1.8 1 0 0 1 1 1 1 IMS family HHH motif Pyridoxal_deC PF00282.19 EXF83976.1 - 7.6e-14 51.2 0.0 1.2e-13 50.6 0.0 1.4 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.19 EXF83976.1 - 0.0011 18.0 0.0 0.0036 16.3 0.0 1.8 1 1 0 1 1 1 1 Aminotransferase class-V Glyco_transf_34 PF05637.12 EXF83977.1 - 5.6e-74 248.9 0.0 6.8e-74 248.6 0.0 1.0 1 0 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family RINGv PF12906.7 EXF83978.1 - 1.5e-10 41.0 2.0 1.6e-09 37.7 0.4 2.2 2 0 0 2 2 2 1 RING-variant domain PHD_4 PF16866.5 EXF83978.1 - 0.0039 17.3 1.7 0.14 12.3 0.0 2.3 1 1 1 2 2 2 1 PHD-finger DUF5516 PF17637.2 EXF83978.1 - 0.047 13.4 0.7 0.11 12.3 0.2 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5516) zf-RING_2 PF13639.6 EXF83978.1 - 0.076 13.4 4.0 0.28 11.6 1.1 2.2 2 0 0 2 2 2 0 Ring finger domain PsbI PF02532.14 EXF83978.1 - 0.31 11.0 2.8 0.77 9.8 2.8 1.6 1 0 0 1 1 1 0 Photosystem II reaction centre I protein (PSII 4.8 kDa protein) Proteasome PF00227.26 EXF83979.1 - 1.7e-51 174.4 0.0 3.4e-27 95.2 0.0 2.2 2 0 0 2 2 2 2 Proteasome subunit Proteasome_A_N PF10584.9 EXF83979.1 - 1.2e-10 40.9 0.3 3.1e-10 39.6 0.0 1.8 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature Peptidase_S13 PF02113.15 EXF83979.1 - 0.25 10.0 0.4 1.3 7.7 0.1 1.9 2 0 0 2 2 2 0 D-Ala-D-Ala carboxypeptidase 3 (S13) family Ribonuclease_3 PF00636.26 EXF83980.1 - 8.4e-40 135.6 0.0 1.7e-20 73.6 0.0 2.5 2 0 0 2 2 2 2 Ribonuclease III domain Ribonucleas_3_3 PF14622.6 EXF83980.1 - 1.7e-22 80.0 0.0 9.3e-10 38.8 0.0 3.6 3 0 0 3 3 3 3 Ribonuclease-III-like Dicer_dimer PF03368.14 EXF83980.1 - 1.2e-21 76.6 0.0 3.8e-21 75.0 0.0 1.9 2 0 0 2 2 2 1 Dicer dimerisation domain DEAD PF00270.29 EXF83980.1 - 1.1e-18 67.6 0.0 2.3e-18 66.6 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EXF83980.1 - 9.6e-18 64.6 0.1 3.1e-17 62.9 0.1 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EXF83980.1 - 1e-13 51.6 0.0 2.3e-13 50.5 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD_2 PF06733.15 EXF83980.1 - 0.073 12.7 0.0 0.18 11.5 0.0 1.5 1 0 0 1 1 1 0 DEAD_2 PRY PF13765.6 EXF83980.1 - 0.088 12.5 0.0 0.21 11.3 0.0 1.6 1 0 0 1 1 1 0 SPRY-associated domain SQHop_cyclase_C PF13243.6 EXF83984.1 - 0.015 14.4 0.0 0.021 13.9 0.0 1.1 1 0 0 1 1 1 0 Squalene-hopene cyclase C-terminal domain Rgp1 PF08737.10 EXF83985.1 - 2.4e-159 531.0 0.0 4.3e-159 530.2 0.0 1.4 1 0 0 1 1 1 1 Rgp1 Arrestin_N PF00339.29 EXF83985.1 - 0.0005 20.1 0.0 0.0011 19.0 0.0 1.5 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 EXF83985.1 - 0.00053 20.4 0.0 0.063 13.7 0.0 2.8 3 0 0 3 3 3 1 Arrestin (or S-antigen), C-terminal domain COesterase PF00135.28 EXF83987.1 - 8.6e-24 84.3 0.0 1.1e-23 83.9 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family ABC_tran PF00005.27 EXF83988.1 - 1.9e-49 167.7 0.0 1.8e-30 106.2 0.0 2.5 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EXF83988.1 - 2.6e-28 99.4 17.5 2.7e-22 79.7 9.5 3.5 5 0 0 5 5 5 2 ABC transporter transmembrane region SMC_N PF02463.19 EXF83988.1 - 2.5e-09 36.9 2.7 0.00015 21.3 0.3 4.2 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 EXF83988.1 - 0.0013 18.7 0.3 1.2 9.0 0.1 2.3 2 0 0 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 EXF83988.1 - 0.0015 19.0 0.0 0.43 10.9 0.0 2.7 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EXF83988.1 - 0.0035 17.6 0.5 3.6 7.8 0.1 3.2 2 1 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 EXF83988.1 - 0.0037 17.3 0.1 0.067 13.3 0.0 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase T2SSE PF00437.20 EXF83988.1 - 0.0038 16.3 0.1 2.8 6.9 0.0 2.3 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_29 PF13555.6 EXF83988.1 - 0.0048 16.6 0.9 2.9 7.7 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_23 PF13476.6 EXF83988.1 - 0.0082 16.7 2.2 4.6 7.7 0.0 3.2 3 0 0 3 3 3 1 AAA domain AAA_25 PF13481.6 EXF83988.1 - 0.012 15.2 0.1 1.1 8.8 0.0 2.5 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 EXF83988.1 - 0.044 13.5 0.7 1.8 8.3 0.0 2.7 3 0 0 3 3 3 0 IstB-like ATP binding protein AAA_21 PF13304.6 EXF83988.1 - 0.058 13.2 1.3 16 5.2 0.3 3.5 2 2 1 4 4 4 0 AAA domain, putative AbiEii toxin, Type IV TA system FAM176 PF14851.6 EXF83988.1 - 0.092 12.4 0.2 0.55 9.9 0.1 2.3 2 0 0 2 2 2 0 FAM176 family AAA_30 PF13604.6 EXF83988.1 - 0.1 12.3 0.0 6.4 6.4 0.1 2.8 3 0 0 3 3 3 0 AAA domain CNOT1_HEAT PF16418.5 EXF83988.1 - 0.11 12.5 0.0 0.24 11.4 0.0 1.5 1 0 0 1 1 1 0 CCR4-NOT transcription complex subunit 1 HEAT repeat DUF2075 PF09848.9 EXF83988.1 - 0.12 11.5 0.1 2.6 7.2 0.0 2.5 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) DUF4834 PF16118.5 EXF83988.1 - 0.13 13.2 0.0 1.5 9.8 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) AAA_7 PF12775.7 EXF83988.1 - 0.13 11.8 0.3 16 5.0 0.0 2.5 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_24 PF13479.6 EXF83988.1 - 0.13 11.9 0.0 0.64 9.7 0.0 2.1 2 0 0 2 2 2 0 AAA domain MeaB PF03308.16 EXF83988.1 - 0.13 11.2 0.1 0.26 10.2 0.1 1.4 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB DUF87 PF01935.17 EXF83988.1 - 1.8 8.6 7.2 1.7 8.7 0.2 3.1 3 0 0 3 3 3 0 Helicase HerA, central domain SF3A2 PF16835.5 EXF83990.1 - 2.2e-34 117.7 0.1 3.6e-34 117.0 0.1 1.3 1 0 0 1 1 1 1 Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) zf-met PF12874.7 EXF83990.1 - 3.4e-06 27.2 0.9 6.9e-06 26.3 0.9 1.5 1 0 0 1 1 1 1 Zinc-finger of C2H2 type CactinC_cactus PF09732.9 EXF83990.1 - 6.1e-05 22.9 0.3 8.9e-05 22.4 0.3 1.2 1 0 0 1 1 1 1 Cactus-binding C-terminus of cactin protein PRP4 PF08799.11 EXF83990.1 - 0.057 13.0 1.5 0.11 12.1 1.5 1.5 1 0 0 1 1 1 0 pre-mRNA processing factor 4 (PRP4) like HET PF06985.11 EXF83991.1 - 6.7e-20 71.9 0.1 4.5e-19 69.2 0.1 2.3 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Lipase_GDSL_2 PF13472.6 EXF83994.1 - 1.3e-17 64.8 0.1 1.8e-17 64.3 0.1 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EXF83994.1 - 1.8e-13 51.0 0.1 2.3e-13 50.6 0.1 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_3 PF14606.6 EXF83994.1 - 0.00061 20.0 0.1 0.00093 19.4 0.1 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family GFA PF04828.14 EXF83995.1 - 2e-10 40.8 0.6 3.4e-10 40.1 0.6 1.3 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme RNA_POL_M_15KD PF02150.16 EXF83995.1 - 0.21 11.5 0.0 0.21 11.5 0.0 1.7 2 0 0 2 2 2 0 RNA polymerases M/15 Kd subunit DUF5597 PF18120.1 EXF83996.1 - 5.6e-27 94.5 0.1 9.1e-27 93.8 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF5597) Glyco_hydro_42 PF02449.15 EXF83996.1 - 4.6e-10 39.4 0.0 7.5e-10 38.7 0.0 1.3 1 0 0 1 1 1 1 Beta-galactosidase Glyco_hydro_35 PF01301.19 EXF83996.1 - 2.2e-05 24.3 0.0 0.0029 17.3 0.0 2.1 2 0 0 2 2 2 2 Glycosyl hydrolases family 35 Glyco_hydro_10 PF00331.20 EXF83996.1 - 0.11 11.7 0.0 0.17 11.0 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 10 Fungal_trans PF04082.18 EXF83997.1 - 0.0049 15.9 0.0 0.29 10.1 0.0 2.2 2 0 0 2 2 2 2 Fungal specific transcription factor domain VCX_VCY PF15231.6 EXF83997.1 - 1.5 9.5 4.9 2.6 8.7 4.9 1.3 1 0 0 1 1 1 0 Variable charge X/Y family Sugar_tr PF00083.24 EXF83998.1 - 1.8e-87 294.1 24.1 2.2e-87 293.8 24.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF83998.1 - 7.9e-20 71.1 38.7 2.2e-14 53.2 12.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Pectate_lyase PF03211.13 EXF83999.1 - 1.8e-64 217.0 0.9 2.4e-64 216.6 0.9 1.1 1 0 0 1 1 1 1 Pectate lyase Cu-oxidase_3 PF07732.15 EXF84001.1 - 1.5e-43 147.6 6.5 1.3e-41 141.3 0.9 3.9 4 0 0 4 4 4 2 Multicopper oxidase Cu-oxidase_2 PF07731.14 EXF84001.1 - 1.2e-39 135.2 5.0 1.7e-36 125.0 0.2 2.8 2 1 0 2 2 2 2 Multicopper oxidase Cu-oxidase PF00394.22 EXF84001.1 - 1.3e-38 132.6 0.5 8.7e-36 123.4 0.3 2.5 2 0 0 2 2 2 2 Multicopper oxidase FTR1 PF03239.14 EXF84002.1 - 7.5e-76 255.2 10.4 8.6e-76 255.0 10.4 1.0 1 0 0 1 1 1 1 Iron permease FTR1 family NAD_binding_6 PF08030.12 EXF84003.1 - 1.1e-18 67.9 0.0 1.6e-18 67.3 0.0 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.19 EXF84003.1 - 2.5e-16 59.9 10.8 4.1e-15 56.0 10.3 2.3 2 0 0 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 EXF84003.1 - 5e-13 49.1 0.0 1e-12 48.1 0.0 1.5 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_1 PF00175.21 EXF84003.1 - 0.0032 18.1 0.0 0.043 14.5 0.0 2.2 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain PAP2 PF01569.21 EXF84004.1 - 3.6e-22 78.6 3.8 8.4e-22 77.4 0.6 2.5 2 1 0 2 2 2 1 PAP2 superfamily Glyco_hydro_43 PF04616.14 EXF84005.1 - 1.2e-36 126.5 6.8 1.6e-36 126.1 6.8 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 GH43_C2 PF17851.1 EXF84005.1 - 2.6e-21 76.3 0.0 4.4e-21 75.5 0.0 1.4 1 0 0 1 1 1 1 Beta xylosidase C-terminal Concanavalin A-like domain LysM PF01476.20 EXF84006.1 - 1.6e-20 72.9 0.6 1.6e-10 40.9 0.2 2.2 2 0 0 2 2 2 2 LysM domain Glyco_hydro_16 PF00722.21 EXF84007.1 - 1.5e-13 50.6 1.1 2e-13 50.2 1.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 AMP-binding PF00501.28 EXF84009.1 - 1.1e-75 254.9 0.1 1.3e-75 254.6 0.1 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EXF84009.1 - 1.6e-15 57.8 0.1 3.8e-15 56.6 0.1 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Sugar_tr PF00083.24 EXF84010.1 - 8.5e-80 268.8 11.0 9.8e-80 268.6 11.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF84010.1 - 3.2e-14 52.6 13.8 3.2e-14 52.6 13.8 1.7 1 1 0 1 1 1 1 Major Facilitator Superfamily MFS_5 PF05631.14 EXF84010.1 - 0.0062 15.5 1.8 0.02 13.8 0.3 2.1 2 0 0 2 2 2 1 Sugar-tranasporters, 12 TM Potex_coat PF06184.11 EXF84010.1 - 0.095 12.3 0.0 0.16 11.6 0.0 1.3 1 0 0 1 1 1 0 Potexvirus coat protein NmrA PF05368.13 EXF84011.1 - 4e-15 56.0 0.0 5.5e-15 55.5 0.0 1.3 1 1 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EXF84011.1 - 3.9e-13 49.7 0.0 7.6e-13 48.8 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EXF84011.1 - 0.0001 21.9 0.0 0.0002 20.9 0.1 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.24 EXF84011.1 - 0.012 16.1 0.3 0.07 13.6 0.1 2.1 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 EXF84011.1 - 0.12 12.4 0.0 0.19 11.8 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Ferric_reduct PF01794.19 EXF84012.1 - 3.2e-18 66.1 5.2 3.2e-18 66.1 5.2 2.6 2 1 0 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 EXF84012.1 - 0.0091 16.1 0.1 0.02 15.0 0.1 1.6 1 1 0 1 1 1 1 FAD-binding domain NAD_binding_1 PF00175.21 EXF84012.1 - 0.0094 16.6 0.0 0.018 15.7 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 EXF84012.1 - 0.016 15.3 0.0 0.048 13.8 0.0 1.7 1 1 1 2 2 2 0 Ferric reductase NAD binding domain DUF2839 PF10999.8 EXF84012.1 - 0.25 11.7 2.7 0.44 10.9 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2839) PhoD PF09423.10 EXF84014.1 - 5e-116 387.5 2.1 6.1e-116 387.3 2.1 1.1 1 0 0 1 1 1 1 PhoD-like phosphatase PhoD_N PF16655.5 EXF84014.1 - 7.2e-24 84.2 0.2 1.7e-23 82.9 0.2 1.7 1 0 0 1 1 1 1 PhoD-like phosphatase, N-terminal domain DUF5012 PF16404.5 EXF84014.1 - 0.8 9.8 4.4 0.31 11.1 0.2 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF5012) Macoilin PF09726.9 EXF84015.1 - 3.1 6.2 7.4 5.7 5.4 7.4 1.4 1 0 0 1 1 1 0 Macoilin family Pol_alpha_B_N PF08418.10 EXF84015.1 - 5.4 6.9 11.8 12 5.8 8.2 2.3 2 0 0 2 2 2 0 DNA polymerase alpha subunit B N-terminal Methyltransf_23 PF13489.6 EXF84016.1 - 1e-11 44.9 0.0 1.5e-11 44.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF84016.1 - 0.00019 21.2 0.0 0.00029 20.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF84016.1 - 0.0087 16.8 0.0 0.028 15.1 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF84016.1 - 0.057 14.2 0.0 0.14 12.9 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_11 PF08241.12 EXF84016.1 - 0.083 13.6 0.0 0.22 12.2 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase domain Oxidored_molyb PF00174.19 EXF84017.1 - 6.6e-45 152.8 0.0 1.6e-44 151.5 0.0 1.6 2 0 0 2 2 2 1 Oxidoreductase molybdopterin binding domain Mo-co_dimer PF03404.16 EXF84017.1 - 5.7e-21 75.0 3.8 1.1e-20 74.1 3.8 1.4 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain Methyltransf_23 PF13489.6 EXF84018.1 - 5.7e-15 55.5 0.0 8.1e-15 55.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF84018.1 - 0.00025 21.7 0.0 0.00047 20.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF84018.1 - 0.00025 21.7 0.0 0.00048 20.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF84018.1 - 0.00036 20.4 0.0 0.00058 19.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF84018.1 - 0.0022 18.6 0.0 0.0046 17.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain FAD_binding_4 PF01565.23 EXF84019.1 - 3.3e-18 65.7 0.2 5.7e-18 65.0 0.2 1.4 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EXF84019.1 - 0.00071 19.6 0.1 0.0017 18.4 0.1 1.6 1 0 0 1 1 1 1 Berberine and berberine like Aldedh PF00171.22 EXF84020.1 - 1.3e-162 541.5 0.4 1.5e-162 541.4 0.4 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 EXF84020.1 - 0.0035 16.8 0.1 0.1 12.0 0.0 2.5 3 0 0 3 3 3 1 Protein of unknown function (DUF1487) BTB PF00651.31 EXF84021.1 - 0.0082 16.4 0.0 0.018 15.3 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain AAA PF00004.29 EXF84022.1 - 4.7e-19 69.1 0.0 8e-19 68.4 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EXF84022.1 - 0.00013 22.3 0.5 0.0014 18.9 0.0 2.5 2 1 1 3 3 3 1 AAA domain AAA_5 PF07728.14 EXF84022.1 - 0.00015 21.8 0.0 0.0004 20.4 0.0 1.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EXF84022.1 - 0.00075 19.9 0.1 0.0025 18.2 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain Zot PF05707.12 EXF84022.1 - 0.0014 18.3 0.1 0.023 14.3 0.0 2.4 1 1 0 2 2 2 1 Zonular occludens toxin (Zot) AAA_18 PF13238.6 EXF84022.1 - 0.0034 17.9 0.4 0.081 13.5 0.0 2.9 3 1 1 4 4 3 1 AAA domain AAA_2 PF07724.14 EXF84022.1 - 0.0099 16.0 0.0 0.021 14.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) IstB_IS21 PF01695.17 EXF84022.1 - 0.031 14.0 0.0 0.071 12.8 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_14 PF13173.6 EXF84022.1 - 0.058 13.4 0.0 0.13 12.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 EXF84022.1 - 0.069 12.6 0.3 1.4 8.3 0.3 2.8 2 1 0 2 2 2 0 PhoH-like protein T2SSE PF00437.20 EXF84022.1 - 0.07 12.2 0.0 0.11 11.5 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein Mg_chelatase PF01078.21 EXF84022.1 - 0.1 12.0 0.1 0.18 11.2 0.1 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 EXF84022.1 - 0.1 12.8 0.1 0.31 11.3 0.0 1.9 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 EXF84022.1 - 0.11 11.8 0.0 0.21 10.8 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_11 PF13086.6 EXF84022.1 - 0.18 11.5 0.0 0.18 11.5 0.0 1.9 2 0 0 2 2 2 0 AAA domain MFS_1 PF07690.16 EXF84024.1 - 3.8e-32 111.6 34.2 5e-32 111.2 34.2 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily PTPLA PF04387.14 EXF84025.1 - 4.3e-49 166.4 10.6 6.7e-49 165.8 10.6 1.3 1 0 0 1 1 1 1 Protein tyrosine phosphatase-like protein, PTPLA 2-oxoacid_dh PF00198.23 EXF84026.1 - 6.6e-72 241.7 0.0 1.2e-71 240.9 0.0 1.4 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 EXF84026.1 - 5.1e-18 64.7 4.4 8.9e-18 63.9 4.4 1.4 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 EXF84026.1 - 1e-05 25.2 0.6 0.00018 21.3 0.1 2.5 1 1 1 2 2 2 1 Biotin-lipoyl like HlyD_3 PF13437.6 EXF84026.1 - 0.00093 19.9 0.9 0.33 11.7 0.1 2.6 1 1 1 2 2 2 2 HlyD family secretion protein GCV_H PF01597.19 EXF84026.1 - 0.0032 17.4 2.1 0.0098 15.8 1.9 1.9 1 1 1 2 2 2 1 Glycine cleavage H-protein HlyD_D23 PF16576.5 EXF84026.1 - 0.0051 16.0 0.3 0.047 12.9 0.1 2.2 1 1 1 2 2 2 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion RnfC_N PF13375.6 EXF84026.1 - 0.013 15.5 3.3 1.6 8.7 0.2 3.0 2 1 1 3 3 3 0 RnfC Barrel sandwich hybrid domain DUF2118 PF09891.9 EXF84026.1 - 0.04 13.9 0.7 0.27 11.2 0.2 2.1 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2118) RR_TM4-6 PF06459.12 EXF84026.1 - 0.54 10.0 9.5 0.93 9.3 9.5 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Presenilin PF01080.17 EXF84026.1 - 0.58 8.9 4.1 0.85 8.3 4.1 1.2 1 0 0 1 1 1 0 Presenilin DUF4551 PF15087.6 EXF84026.1 - 3.9 6.2 5.0 6.3 5.5 5.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) SRP-alpha_N PF04086.13 EXF84026.1 - 4.5 7.1 9.6 7.2 6.4 9.6 1.3 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Trypan_PARP PF05887.11 EXF84026.1 - 7.2 6.6 21.6 13 5.7 21.6 1.4 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Transket_pyr PF02779.24 EXF84027.1 - 2.8e-59 199.8 0.0 4.3e-59 199.2 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain E1_dh PF00676.20 EXF84027.1 - 1.1e-54 185.5 0.0 1.9e-54 184.6 0.0 1.3 1 0 0 1 1 1 1 Dehydrogenase E1 component OxoGdeHyase_C PF16870.5 EXF84027.1 - 4.3e-52 175.8 0.0 7.3e-52 175.1 0.0 1.4 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase C-terminal 2-oxogl_dehyd_N PF16078.5 EXF84027.1 - 4e-09 35.9 0.8 4e-09 35.9 0.8 1.9 2 0 0 2 2 2 1 2-oxoglutarate dehydrogenase N-terminus Amino_oxidase PF01593.24 EXF84028.1 - 5.4e-23 82.0 0.0 4.9e-15 55.8 0.0 2.2 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EXF84028.1 - 0.00034 20.8 0.0 0.00076 19.7 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain PG_isomerase_N PF18353.1 EXF84028.1 - 0.017 15.5 0.0 0.35 11.3 0.0 2.6 2 0 0 2 2 2 0 Phosphoglucose isomerase N-terminal domain PknG_TPR PF16918.5 EXF84028.1 - 0.11 11.2 0.6 0.22 10.2 0.3 1.5 2 0 0 2 2 2 0 Protein kinase G tetratricopeptide repeat DUF3328 PF11807.8 EXF84029.1 - 1.8e-29 103.1 7.6 6e-28 98.1 7.6 2.5 1 1 0 1 1 1 1 Domain of unknown function (DUF3328) RNase_T PF00929.24 EXF84031.1 - 0.00016 22.3 0.0 0.00023 21.7 0.0 1.3 1 0 0 1 1 1 1 Exonuclease DNA_pol_A_exo1 PF01612.20 EXF84031.1 - 0.0087 15.8 0.0 0.014 15.1 0.0 1.3 1 0 0 1 1 1 1 3'-5' exonuclease zf-C2H2 PF00096.26 EXF84031.1 - 0.012 16.0 0.8 0.041 14.3 0.5 2.1 2 0 0 2 2 2 0 Zinc finger, C2H2 type Herpes_UL49_2 PF04823.12 EXF84031.1 - 0.016 15.3 0.1 0.04 14.0 0.1 1.6 1 0 0 1 1 1 0 Herpesvirus UL49 tegument protein zf-C2H2_4 PF13894.6 EXF84031.1 - 0.023 15.5 0.5 0.078 13.9 0.5 2.0 1 0 0 1 1 1 0 C2H2-type zinc finger Oxysterol_BP PF01237.18 EXF84032.1 - 1.7e-55 188.4 0.6 3e-48 164.6 0.0 2.0 1 1 1 2 2 2 2 Oxysterol-binding protein Peptidase_S10 PF00450.22 EXF84034.1 - 2.9e-81 274.0 1.0 4.2e-81 273.5 1.0 1.2 1 0 0 1 1 1 1 Serine carboxypeptidase CFEM PF05730.11 EXF84035.1 - 0.0019 18.2 11.5 0.0043 17.1 11.5 1.5 1 0 0 1 1 1 1 CFEM domain VSG_B PF13206.6 EXF84035.1 - 4.6 6.4 7.3 7.5 5.7 7.3 1.2 1 0 0 1 1 1 0 Trypanosomal VSG domain MFS_1 PF07690.16 EXF84036.1 - 1.2e-21 77.1 32.6 1.2e-21 77.1 32.6 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EXF84036.1 - 9.8e-07 27.6 5.7 1.7e-06 26.7 5.7 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EXF84036.1 - 4.2e-05 22.6 19.6 0.00023 20.2 19.5 2.1 1 1 0 1 1 1 1 Sugar (and other) transporter Zn_clus PF00172.18 EXF84037.1 - 4.4e-06 26.7 12.4 8.3e-06 25.8 12.4 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EXF84037.1 - 0.00012 21.1 0.3 0.00029 19.8 0.3 1.6 1 1 0 1 1 1 1 Fungal specific transcription factor domain SQS_PSY PF00494.19 EXF84037.1 - 0.046 13.2 0.0 0.16 11.4 0.1 1.8 2 0 0 2 2 2 0 Squalene/phytoene synthase PADR1 PF08063.12 EXF84037.1 - 1.4 8.7 7.3 2.9 7.7 7.3 1.5 1 0 0 1 1 1 0 PADR1 (NUC008) domain RTA1 PF04479.13 EXF84038.1 - 2.7e-71 239.4 9.7 3.4e-71 239.1 9.7 1.1 1 0 0 1 1 1 1 RTA1 like protein Syndecan PF01034.20 EXF84038.1 - 0.026 14.4 0.2 0.026 14.4 0.2 2.7 3 1 1 4 4 4 0 Syndecan domain SKG6 PF08693.10 EXF84040.1 - 0.00084 18.7 0.8 0.0015 17.9 0.8 1.4 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Mid2 PF04478.12 EXF84040.1 - 0.038 13.8 0.2 0.085 12.7 0.2 1.6 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor DUF5305 PF17231.2 EXF84040.1 - 0.095 12.1 0.1 0.15 11.5 0.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5305) Cyt-b5 PF00173.28 EXF84041.1 - 3.7e-12 46.2 0.0 5.7e-12 45.6 0.0 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Glyco_hydro_61 PF03443.14 EXF84041.1 - 1.3e-06 28.5 0.0 1.8e-06 28.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 Scytalone_dh PF02982.14 EXF84042.1 - 1.3e-97 324.1 1.3 1.5e-97 323.9 1.3 1.0 1 0 0 1 1 1 1 Scytalone dehydratase SnoaL_4 PF13577.6 EXF84042.1 - 8.8e-08 32.3 0.2 1.2e-07 31.9 0.2 1.2 1 0 0 1 1 1 1 SnoaL-like domain HET PF06985.11 EXF84043.1 - 8.9e-13 48.8 2.1 3.1e-09 37.3 0.1 2.5 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) Glyco_hydro_62 PF03664.13 EXF84044.1 - 1.4e-157 523.1 16.6 1.6e-157 522.9 16.6 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 62 MIP PF00230.20 EXF84045.1 - 1.7e-45 155.5 8.1 2e-45 155.3 8.1 1.1 1 0 0 1 1 1 1 Major intrinsic protein Asp PF00026.23 EXF84046.1 - 1.8e-53 182.0 0.0 2.5e-53 181.6 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EXF84046.1 - 2e-10 41.2 2.0 4.8e-10 40.0 2.0 1.7 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EXF84046.1 - 0.001 19.7 0.2 9.1 7.0 0.1 3.4 2 1 0 2 2 2 2 Aspartyl protease Kelch_5 PF13854.6 EXF84047.1 - 3e-13 49.4 1.4 1.6e-10 40.7 0.2 3.7 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.6 EXF84047.1 - 0.00015 21.7 14.4 0.0062 16.5 0.2 5.4 5 0 0 5 5 5 1 Galactose oxidase, central domain Gly-zipper_YMGG PF13441.6 EXF84047.1 - 0.00053 19.7 1.5 0.0014 18.3 1.5 1.7 1 0 0 1 1 1 1 YMGG-like Gly-zipper Gly-zipper_Omp PF13488.6 EXF84047.1 - 0.013 15.5 6.7 0.042 13.9 6.7 1.8 1 0 0 1 1 1 0 Glycine zipper Rick_17kDa_Anti PF05433.15 EXF84047.1 - 0.014 15.2 4.7 0.046 13.6 4.7 1.9 1 0 0 1 1 1 0 Glycine zipper 2TM domain DUF456 PF04306.13 EXF84047.1 - 0.017 15.4 0.7 0.034 14.5 0.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF456) CD99L2 PF12301.8 EXF84047.1 - 0.028 14.7 0.0 0.062 13.6 0.0 1.6 1 0 0 1 1 1 0 CD99 antigen like protein 2 Kelch_2 PF07646.15 EXF84047.1 - 0.1 12.6 4.0 1.3 9.1 0.2 3.9 3 0 0 3 3 3 0 Kelch motif Kelch_1 PF01344.25 EXF84047.1 - 0.27 10.8 9.3 9.7 5.9 0.1 4.6 4 0 0 4 4 4 0 Kelch motif Romo1 PF10247.9 EXF84047.1 - 0.31 11.5 2.1 0.53 10.7 0.1 2.2 2 0 0 2 2 2 0 Reactive mitochondrial oxygen species modulator 1 Gly-zipper_OmpA PF13436.6 EXF84047.1 - 1.9 8.3 7.7 5.6 6.8 7.7 1.8 1 0 0 1 1 1 0 Glycine-zipper domain UDPGT PF00201.18 EXF84048.1 - 0.0002 20.3 0.0 0.0003 19.7 0.0 1.2 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 EXF84048.1 - 0.033 14.2 0.0 0.14 12.2 0.0 1.9 1 1 0 1 1 1 0 Glycosyltransferase family 28 C-terminal domain Glyco_trans_1_4 PF13692.6 EXF84048.1 - 0.11 13.0 0.0 1.7 9.1 0.0 2.6 2 1 0 2 2 2 0 Glycosyl transferases group 1 Ank_2 PF12796.7 EXF84049.1 - 3.2e-65 216.7 5.0 2.7e-10 40.7 0.1 8.6 1 1 7 8 8 8 8 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EXF84049.1 - 3.2e-55 183.8 10.6 1.4e-09 38.3 0.4 10.0 4 3 6 10 10 10 10 Ankyrin repeats (many copies) Ank_5 PF13857.6 EXF84049.1 - 1e-48 162.8 6.4 3.5e-08 33.6 0.1 10.1 5 3 6 11 11 11 10 Ankyrin repeats (many copies) Ank PF00023.30 EXF84049.1 - 2.7e-48 160.4 4.2 3.9e-05 23.9 0.0 11.8 13 0 0 13 13 13 9 Ankyrin repeat Ank_3 PF13606.6 EXF84049.1 - 1.3e-36 120.5 2.0 0.00092 19.5 0.0 12.5 13 0 0 13 13 13 7 Ankyrin repeat SesA PF17107.5 EXF84049.1 - 2.8e-32 111.5 0.6 8.4e-32 109.9 0.3 2.1 2 0 0 2 2 2 1 N-terminal domain on NACHT_NTPase and P-loop NTPases NACHT PF05729.12 EXF84049.1 - 0.029 14.3 0.0 0.069 13.1 0.0 1.6 1 0 0 1 1 1 0 NACHT domain CEP76-C2 PF15627.6 EXF84049.1 - 0.046 13.3 0.1 1.4 8.5 0.1 2.4 2 0 0 2 2 2 0 CEP76 C2 domain Glyco_hydro_61 PF03443.14 EXF84051.1 - 8.6e-61 205.4 0.1 1.2e-60 204.9 0.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 CBM_1 PF00734.18 EXF84051.1 - 3.5e-09 36.5 12.8 3.5e-09 36.5 12.8 3.8 3 2 1 4 4 4 1 Fungal cellulose binding domain Cellulase PF00150.18 EXF84052.1 - 2.1e-22 79.9 4.3 2.8e-22 79.5 4.3 1.1 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_2_C PF02836.17 EXF84052.1 - 4.5e-08 32.6 0.0 9.4e-08 31.5 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_42 PF02449.15 EXF84052.1 - 0.00041 19.8 0.8 0.0013 18.2 0.0 2.0 3 0 0 3 3 3 1 Beta-galactosidase Hfq PF17209.3 EXF84052.1 - 0.16 11.7 0.1 0.45 10.2 0.0 1.7 2 0 0 2 2 2 0 Hfq protein Solute_trans_a PF03619.16 EXF84053.1 - 1.4e-58 198.5 20.1 8.2e-58 196.0 20.1 1.9 1 1 0 1 1 1 1 Organic solute transporter Ostalpha GPR_Gpa2_C PF11970.8 EXF84053.1 - 0.6 10.2 3.5 1.1 9.3 1.0 2.6 2 1 0 2 2 2 0 G protein-coupled glucose receptor regulating Gpa2 C-term DUF2628 PF10947.8 EXF84053.1 - 3.1 8.2 7.9 2.5 8.5 0.9 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF2628) FA_hydroxylase PF04116.13 EXF84056.1 - 1.1e-23 84.0 20.8 1.1e-23 84.0 20.8 2.0 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily Fungal_trans_2 PF11951.8 EXF84057.1 - 3.1e-18 65.8 3.5 2.4e-17 62.9 3.5 2.0 1 1 0 1 1 1 1 Fungal specific transcription factor domain Acetyltransf_1 PF00583.25 EXF84057.1 - 1.9e-06 28.1 0.0 5.1e-06 26.7 0.0 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EXF84057.1 - 3.4e-06 27.4 0.0 8.6e-06 26.1 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EXF84057.1 - 1.1e-05 25.4 0.0 2.2e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EXF84057.1 - 0.0049 17.0 0.0 0.01 16.0 0.0 1.6 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_9 PF13527.7 EXF84057.1 - 0.17 12.0 0.1 12 6.0 0.0 2.9 3 0 0 3 3 3 0 Acetyltransferase (GNAT) domain DAO PF01266.24 EXF84058.1 - 1.6e-32 113.5 1.2 2e-32 113.2 1.2 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EXF84058.1 - 0.001 19.2 0.9 0.0021 18.3 0.9 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 EXF84058.1 - 0.012 15.6 0.0 0.035 14.1 0.2 1.7 2 0 0 2 2 2 0 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 EXF84058.1 - 0.032 13.5 0.0 0.061 12.5 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase AA_permease_2 PF13520.6 EXF84059.1 - 3.9e-42 144.6 47.6 4.8e-42 144.3 47.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EXF84059.1 - 1.3e-12 47.1 40.3 1.8e-12 46.6 40.3 1.0 1 0 0 1 1 1 1 Amino acid permease Cupin_1 PF00190.22 EXF84060.1 - 1e-36 125.8 0.0 9.9e-18 64.2 0.0 2.2 2 0 0 2 2 2 2 Cupin Cupin_2 PF07883.11 EXF84060.1 - 8.1e-20 70.3 0.1 9e-12 44.5 0.2 2.4 2 0 0 2 2 2 2 Cupin domain Cupin_3 PF05899.12 EXF84060.1 - 1.5e-07 31.0 0.1 0.00086 19.0 0.1 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF861) MannoseP_isomer PF01050.18 EXF84060.1 - 1.7e-05 24.8 0.0 0.0022 17.9 0.0 2.2 2 0 0 2 2 2 1 Mannose-6-phosphate isomerase AraC_binding PF02311.19 EXF84060.1 - 0.00021 21.2 0.0 0.093 12.6 0.0 2.6 3 0 0 3 3 3 2 AraC-like ligand binding domain 3-HAO PF06052.12 EXF84060.1 - 0.0098 15.5 0.0 0.042 13.5 0.0 1.9 2 0 0 2 2 2 1 3-hydroxyanthranilic acid dioxygenase Cupin_6 PF12852.7 EXF84060.1 - 0.044 13.5 0.0 0.85 9.3 0.0 2.4 2 0 0 2 2 2 0 Cupin OATP PF03137.20 EXF84061.1 - 0.18 10.0 2.9 0.18 10.0 2.9 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family DUF3543 PF12063.8 EXF84063.1 - 1.7e-89 299.5 0.2 2.6e-89 298.9 0.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3543) Pkinase PF00069.25 EXF84063.1 - 2e-59 201.1 0.0 3.5e-59 200.3 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF84063.1 - 2.8e-42 144.8 0.0 5e-42 144.0 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase MIT PF04212.18 EXF84063.1 - 0.0025 17.8 0.3 0.24 11.5 0.1 2.5 2 0 0 2 2 2 1 MIT (microtubule interacting and transport) domain Peptidase_M1 PF01433.20 EXF84065.1 - 3.9e-44 150.8 0.5 5.3e-44 150.4 0.5 1.2 1 0 0 1 1 1 1 Peptidase family M1 domain Leuk-A4-hydro_C PF09127.11 EXF84065.1 - 6.4e-38 129.3 0.0 1.7e-37 128.0 0.0 1.7 2 0 0 2 2 2 1 Leukotriene A4 hydrolase, C-terminal Peptidase_M1_N PF17900.1 EXF84065.1 - 2.2e-29 102.9 0.0 3.6e-29 102.3 0.0 1.3 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain TbpB_B_D PF01298.18 EXF84065.1 - 0.019 15.3 0.1 0.038 14.4 0.1 1.4 1 0 0 1 1 1 0 C-lobe and N-lobe beta barrels of Tf-binding protein B Svf1 PF08622.10 EXF84065.1 - 0.096 12.7 0.0 0.17 12.0 0.0 1.4 1 0 0 1 1 1 0 Svf1-like N-terminal lipocalin domain Peptidase_M61 PF05299.12 EXF84065.1 - 0.52 10.7 2.7 13 6.2 2.7 2.6 1 1 0 1 1 1 0 M61 glycyl aminopeptidase Ank_2 PF12796.7 EXF84067.1 - 7.9e-44 148.2 2.3 1.6e-10 41.4 0.0 6.2 2 2 5 7 7 7 7 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EXF84067.1 - 8.1e-30 102.5 7.2 1.9e-07 31.2 0.0 7.7 3 2 5 8 8 8 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EXF84067.1 - 1.4e-26 89.6 9.0 0.0046 17.3 0.0 12.6 13 0 0 13 13 13 5 Ankyrin repeat Ank_4 PF13637.6 EXF84067.1 - 3.5e-26 91.2 3.9 3.3e-05 24.3 0.0 8.2 3 1 5 8 8 8 7 Ankyrin repeats (many copies) Ank PF00023.30 EXF84067.1 - 5e-25 86.8 11.8 0.00061 20.1 0.0 10.1 9 2 1 10 10 10 6 Ankyrin repeat AAA_16 PF13191.6 EXF84067.1 - 5e-10 40.0 0.4 1.6e-09 38.4 0.4 1.9 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EXF84067.1 - 4e-08 33.6 0.2 2e-06 28.1 0.1 3.1 3 0 0 3 3 3 1 AAA domain NACHT PF05729.12 EXF84067.1 - 6e-07 29.5 0.2 1.3e-06 28.4 0.2 1.6 1 0 0 1 1 1 1 NACHT domain AAA PF00004.29 EXF84067.1 - 0.012 16.1 0.0 0.035 14.5 0.0 1.9 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NB-ARC PF00931.22 EXF84067.1 - 0.024 13.8 0.0 0.044 13.0 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain AAA_25 PF13481.6 EXF84067.1 - 0.052 13.1 0.0 0.15 11.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.9 EXF84067.1 - 0.056 12.7 0.0 0.094 11.9 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) zf-C2H2_11 PF16622.5 EXF84067.1 - 0.2 11.4 0.3 0.48 10.2 0.3 1.6 1 0 0 1 1 1 0 zinc-finger C2H2-type AAA_18 PF13238.6 EXF84067.1 - 0.2 12.2 0.2 3.3 8.3 0.0 2.9 2 1 0 2 2 2 0 AAA domain zf-Di19 PF05605.12 EXF84067.1 - 9.5 6.6 7.5 15 6.0 0.1 2.8 3 0 0 3 3 2 0 Drought induced 19 protein (Di19), zinc-binding DAO PF01266.24 EXF84068.1 - 5.7e-41 141.3 0.6 6.7e-41 141.0 0.6 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EXF84068.1 - 8.1e-09 35.1 0.0 8.3e-05 22.0 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EXF84068.1 - 4.3e-06 26.8 0.3 0.028 14.4 0.2 2.3 2 0 0 2 2 2 2 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 EXF84068.1 - 2.2e-05 24.6 0.1 5.9e-05 23.2 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 EXF84068.1 - 0.0009 18.4 0.2 0.0028 16.8 0.1 1.7 2 0 0 2 2 2 1 Glucose inhibited division protein A HI0933_like PF03486.14 EXF84068.1 - 0.0024 16.6 0.0 0.033 12.9 0.0 2.0 2 0 0 2 2 2 1 HI0933-like protein FAD_binding_2 PF00890.24 EXF84068.1 - 0.0035 16.5 0.1 0.53 9.3 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain Pyr_redox PF00070.27 EXF84068.1 - 0.008 16.7 0.0 0.079 13.5 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EXF84068.1 - 0.019 14.0 0.1 0.19 10.7 0.0 2.0 2 0 0 2 2 2 0 Lycopene cyclase protein Glu_dehyd_C PF16912.5 EXF84068.1 - 0.021 14.3 0.0 0.29 10.6 0.0 2.2 2 0 0 2 2 2 0 Glucose dehydrogenase C-terminus Pyr_redox_3 PF13738.6 EXF84068.1 - 0.027 13.8 0.0 2.1 7.6 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EXF84068.1 - 0.029 13.6 0.0 0.05 12.8 0.0 1.4 1 0 0 1 1 1 0 Thi4 family FAD_binding_3 PF01494.19 EXF84068.1 - 0.031 13.5 0.0 0.057 12.6 0.0 1.4 1 0 0 1 1 1 0 FAD binding domain ICL PF00463.21 EXF84069.1 - 4.5e-300 995.6 1.7 5.1e-300 995.4 1.7 1.0 1 0 0 1 1 1 1 Isocitrate lyase family PEP_mutase PF13714.6 EXF84069.1 - 8.4e-12 45.1 0.2 2.8e-11 43.3 0.0 1.8 2 0 0 2 2 2 1 Phosphoenolpyruvate phosphomutase Trehalase PF01204.18 EXF84070.1 - 3.5e-197 656.3 0.0 4.3e-197 656.0 0.0 1.1 1 0 0 1 1 1 1 Trehalase Trehalase_Ca-bi PF07492.11 EXF84070.1 - 1.1e-16 60.3 0.1 1.9e-16 59.5 0.1 1.4 1 0 0 1 1 1 1 Neutral trehalase Ca2+ binding domain GH-E PF14410.6 EXF84070.1 - 0.11 12.9 0.6 0.47 10.9 0.1 2.3 2 0 0 2 2 2 0 HNH/ENDO VII superfamily nuclease with conserved GHE residues DUF1279 PF06916.13 EXF84071.1 - 1.1e-24 86.8 0.1 2.5e-24 85.6 0.1 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF1279) PNGaseA PF12222.8 EXF84073.1 - 3.6e-153 510.5 0.2 2.4e-101 339.7 0.2 2.1 2 0 0 2 2 2 2 Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A FANCI_HD1 PF14679.6 EXF84074.1 - 0.015 15.3 0.0 0.029 14.3 0.0 1.5 1 0 0 1 1 1 0 FANCI helical domain 1 P5CR_dimer PF14748.6 EXF84075.1 - 9.9e-36 122.1 0.1 9.9e-36 122.1 0.1 2.6 4 0 0 4 4 4 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.17 EXF84075.1 - 4.2e-18 65.7 3.0 1.2e-17 64.3 3.0 1.8 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 EXF84075.1 - 0.0074 16.5 0.8 0.015 15.5 0.8 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase CoA_binding PF02629.19 EXF84075.1 - 0.019 15.6 3.2 0.034 14.8 2.1 2.0 2 0 0 2 2 2 0 CoA binding domain Shikimate_DH PF01488.20 EXF84075.1 - 0.073 13.1 0.5 0.16 12.0 0.2 1.8 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase ABC_cobalt PF09819.9 EXF84075.1 - 0.076 13.1 0.2 0.2 11.8 0.2 1.7 1 0 0 1 1 1 0 ABC-type cobalt transport system, permease component NAD_Gly3P_dh_N PF01210.23 EXF84075.1 - 0.43 10.5 5.5 1.6 8.7 3.9 2.5 2 1 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus PhyH PF05721.13 EXF84077.1 - 7.1e-20 72.2 0.0 9.5e-20 71.8 0.0 1.1 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) Amidohydro_1 PF01979.20 EXF84078.1 - 8.9e-20 71.3 0.0 4.1e-19 69.1 0.0 1.9 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EXF84078.1 - 4.2e-11 43.0 0.3 8.3e-05 22.2 0.0 2.3 2 0 0 2 2 2 2 Amidohydrolase family YbaJ PF10757.9 EXF84078.1 - 0.11 13.0 0.2 1.1 9.9 0.0 2.2 2 0 0 2 2 2 0 Biofilm formation regulator YbaJ Hpr_kinase_C PF07475.12 EXF84078.1 - 0.12 11.8 0.2 0.41 10.2 0.0 1.8 2 0 0 2 2 2 0 HPr Serine kinase C-terminal domain FAD_binding_3 PF01494.19 EXF84079.1 - 0.023 14.0 0.4 0.034 13.4 0.4 1.2 1 0 0 1 1 1 0 FAD binding domain DUF1013 PF06242.11 EXF84079.1 - 0.077 13.0 0.0 0.13 12.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1013) Methyltransf_23 PF13489.6 EXF84081.1 - 2.8e-19 69.6 0.0 4.5e-19 68.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF84081.1 - 1.6e-11 44.8 0.0 9.1e-11 42.3 0.0 2.3 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF84081.1 - 4.4e-10 39.6 0.0 0.00014 21.7 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_11 PF08241.12 EXF84081.1 - 8.6e-08 32.7 0.0 2.4e-07 31.3 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF84081.1 - 3.2e-07 31.0 0.0 5.8e-06 27.0 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EXF84081.1 - 0.0012 18.4 0.0 0.0027 17.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 EXF84081.1 - 0.014 14.8 0.0 0.036 13.5 0.0 1.6 2 0 0 2 2 2 0 Ribosomal protein L11 methyltransferase (PrmA) Ubie_methyltran PF01209.18 EXF84081.1 - 0.016 14.5 0.0 0.64 9.3 0.0 2.3 2 1 0 2 2 2 0 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.17 EXF84081.1 - 0.021 14.3 0.0 0.2 11.1 0.0 2.2 2 0 0 2 2 2 0 Putative methyltransferase FtsJ PF01728.19 EXF84081.1 - 0.14 12.3 0.0 0.38 10.9 0.0 1.6 1 1 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_16 PF10294.9 EXF84081.1 - 0.15 11.8 0.0 0.22 11.2 0.0 1.2 1 0 0 1 1 1 0 Lysine methyltransferase FMN_dh PF01070.18 EXF84082.1 - 5.6e-97 324.9 0.6 2.1e-96 323.0 0.6 1.7 1 1 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.28 EXF84082.1 - 3.3e-20 72.0 0.0 6.9e-20 71.0 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Glu_synthase PF01645.17 EXF84082.1 - 5.9e-07 29.0 0.1 9.2e-07 28.3 0.1 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.25 EXF84082.1 - 2.8e-05 23.3 0.3 0.00036 19.6 0.1 2.1 2 0 0 2 2 2 1 IMP dehydrogenase / GMP reductase domain NMO PF03060.15 EXF84082.1 - 0.0065 15.9 0.7 0.012 15.0 0.7 1.4 1 0 0 1 1 1 1 Nitronate monooxygenase His_biosynth PF00977.21 EXF84082.1 - 0.023 14.1 0.1 0.052 13.0 0.1 1.6 1 0 0 1 1 1 0 Histidine biosynthesis protein ThiG PF05690.14 EXF84082.1 - 0.034 13.4 0.1 2.3 7.5 0.1 2.4 1 1 0 2 2 2 0 Thiazole biosynthesis protein ThiG Borrelia_P83 PF05262.11 EXF84083.1 - 0.6 8.5 9.8 0.75 8.2 9.8 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein Sugar_tr PF00083.24 EXF84085.1 - 8.2e-98 328.2 21.3 9.3e-98 328.0 21.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF84085.1 - 1.6e-40 139.1 44.2 9.8e-35 120.1 18.5 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily HET PF06985.11 EXF84086.1 - 4.7e-23 82.2 0.0 2.6e-22 79.7 0.0 2.0 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) DEAD PF00270.29 EXF84087.1 - 4.2e-41 140.6 0.1 6.8e-41 139.9 0.1 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EXF84087.1 - 1.8e-30 105.6 0.3 5e-29 100.9 0.0 2.7 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EXF84087.1 - 5.5e-08 33.0 0.0 1.2e-07 31.9 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Methyltransf_23 PF13489.6 EXF84088.1 - 3e-12 46.7 0.0 4.8e-12 46.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF84088.1 - 1.2e-10 42.1 0.0 1.8e-10 41.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF84088.1 - 2.2e-09 37.9 0.0 3.6e-09 37.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF84088.1 - 2.5e-08 34.5 0.0 4.9e-08 33.5 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF84088.1 - 1.6e-06 28.0 0.0 2.5e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EXF84088.1 - 0.14 11.7 0.0 0.26 10.8 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Sugar_tr PF00083.24 EXF84089.1 - 1.3e-80 271.5 19.9 1.5e-80 271.3 19.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF84089.1 - 1.1e-28 100.2 40.4 5.5e-19 68.3 18.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 EXF84089.1 - 1.3e-05 23.7 1.0 1.3e-05 23.7 1.0 2.3 3 0 0 3 3 3 1 Organic Anion Transporter Polypeptide (OATP) family Trp_oprn_chp PF09534.10 EXF84089.1 - 2.2 8.0 14.8 7.4 6.3 9.6 3.1 2 1 0 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Phage_holin_3_2 PF04550.12 EXF84089.1 - 6.3 7.4 8.2 0.48 11.0 1.4 2.6 2 1 1 3 3 3 0 Phage holin family 2 AflR PF08493.10 EXF84090.1 - 1.2e-11 44.7 2.7 2.2e-11 43.8 2.7 1.4 1 0 0 1 1 1 1 Aflatoxin regulatory protein Zn_clus PF00172.18 EXF84090.1 - 8.7e-09 35.4 10.8 2e-08 34.2 10.8 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Methyltransf_2 PF00891.18 EXF84091.1 - 5.8e-23 81.3 0.0 9.3e-23 80.6 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_25 PF13649.6 EXF84091.1 - 3.6e-05 24.4 0.0 0.0002 22.0 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF84091.1 - 0.0046 16.8 0.0 0.012 15.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EXF84091.1 - 0.0058 16.2 0.0 0.011 15.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain PG_binding_1 PF01471.18 EXF84091.1 - 0.18 12.0 0.0 0.49 10.6 0.0 1.7 1 0 0 1 1 1 0 Putative peptidoglycan binding domain Methyltransf_2 PF00891.18 EXF84092.1 - 1e-27 96.8 0.0 1.6e-27 96.1 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain FAD_binding_3 PF01494.19 EXF84092.1 - 2.3e-16 60.0 0.7 6.8e-10 38.7 1.4 3.2 2 1 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 EXF84092.1 - 0.00063 19.9 0.0 0.0019 18.4 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DUF938 PF06080.12 EXF84092.1 - 0.05 13.4 0.0 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF938) PCMT PF01135.19 EXF84092.1 - 0.086 12.6 0.0 0.16 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Phage_CI_C PF16452.5 EXF84092.1 - 0.15 12.4 0.0 0.45 10.8 0.0 1.8 1 0 0 1 1 1 0 Bacteriophage CI repressor C-terminal domain ketoacyl-synt PF00109.26 EXF84093.1 - 1.9e-74 250.4 0.4 6.3e-74 248.7 0.1 2.0 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain SAT PF16073.5 EXF84093.1 - 9.9e-70 235.0 1.9 9.9e-70 235.0 1.9 2.2 2 0 0 2 2 2 1 Starter unit:ACP transacylase in aflatoxin biosynthesis Acyl_transf_1 PF00698.21 EXF84093.1 - 2.8e-38 132.2 0.8 5.7e-38 131.2 0.5 1.6 2 0 0 2 2 2 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EXF84093.1 - 9.6e-33 112.7 5.3 1.7e-32 111.9 3.7 2.4 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain Thioesterase PF00975.20 EXF84093.1 - 4.3e-25 89.2 0.1 1.9e-24 87.0 0.0 2.2 2 0 0 2 2 2 1 Thioesterase domain PS-DH PF14765.6 EXF84093.1 - 5.1e-14 52.2 0.0 9.7e-14 51.3 0.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase PP-binding PF00550.25 EXF84093.1 - 8.2e-10 38.9 2.4 1.9e-09 37.8 0.9 2.3 2 0 0 2 2 2 1 Phosphopantetheine attachment site Thiolase_N PF00108.23 EXF84093.1 - 1.1e-05 24.9 0.2 7.9e-05 22.1 0.0 2.3 2 0 0 2 2 2 1 Thiolase, N-terminal domain KAsynt_C_assoc PF16197.5 EXF84093.1 - 1.2e-05 25.7 0.0 3e-05 24.4 0.0 1.7 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension ACP_syn_III PF08545.10 EXF84093.1 - 0.084 12.7 0.1 0.43 10.5 0.0 2.2 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Abhydrolase_1 PF00561.20 EXF84093.1 - 0.11 12.2 0.1 0.98 9.0 0.0 2.2 2 0 0 2 2 2 0 alpha/beta hydrolase fold Nuc_recep-AF1 PF11825.8 EXF84093.1 - 8 6.6 9.4 0.6 10.2 3.4 2.3 2 0 0 2 2 1 0 Nuclear/hormone receptor activator site AF-1 FAD_binding_4 PF01565.23 EXF84094.1 - 2.8e-22 79.0 0.1 4.8e-22 78.2 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain NmrA PF05368.13 EXF84095.1 - 4.3e-15 55.9 0.1 1.2e-14 54.5 0.1 1.7 1 1 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EXF84095.1 - 9.4e-15 55.0 0.0 1.5e-14 54.3 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EXF84095.1 - 0.0012 18.4 0.0 0.0023 17.4 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_7 PF13241.6 EXF84095.1 - 0.0016 18.8 0.0 0.0045 17.4 0.0 1.7 2 0 0 2 2 2 1 Putative NAD(P)-binding F420_oxidored PF03807.17 EXF84095.1 - 0.0018 18.8 0.0 0.004 17.7 0.0 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent DFP PF04127.15 EXF84095.1 - 0.0052 16.6 0.7 0.048 13.5 0.0 2.4 1 1 0 3 3 3 1 DNA / pantothenate metabolism flavoprotein NAD_binding_2 PF03446.15 EXF84095.1 - 0.008 16.3 0.0 0.038 14.1 0.0 2.0 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase Shikimate_DH PF01488.20 EXF84095.1 - 0.026 14.6 0.0 0.054 13.6 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Sacchrp_dh_NADP PF03435.18 EXF84095.1 - 0.048 13.9 0.0 0.13 12.6 0.0 1.8 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain 2-Hacid_dh_C PF02826.19 EXF84095.1 - 0.053 12.9 0.0 0.095 12.0 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Polysacc_synt_2 PF02719.15 EXF84095.1 - 0.067 12.3 0.0 0.14 11.2 0.0 1.5 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein Cu-oxidase_3 PF07732.15 EXF84096.1 - 4.7e-38 129.9 2.3 1.1e-37 128.7 0.1 2.6 3 0 0 3 3 3 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 EXF84096.1 - 9.6e-30 103.1 6.2 8e-24 83.9 0.1 4.0 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.22 EXF84096.1 - 5.8e-16 59.0 0.1 1.2e-13 51.5 0.0 2.4 2 0 0 2 2 2 2 Multicopper oxidase ThiS PF02597.20 EXF84096.1 - 0.13 12.9 0.0 0.64 10.7 0.0 2.0 2 0 0 2 2 2 0 ThiS family Fasciclin PF02469.22 EXF84097.1 - 5.4e-30 104.2 0.0 1.2e-16 61.1 0.0 2.2 2 0 0 2 2 2 2 Fasciclin domain CcmD PF04995.14 EXF84097.1 - 0.0015 18.5 0.4 0.0043 17.1 0.4 1.8 1 0 0 1 1 1 1 Heme exporter protein D (CcmD) MFS_1 PF07690.16 EXF84098.1 - 6.6e-40 137.1 28.8 8.2e-40 136.8 28.8 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF84098.1 - 5.2e-15 55.2 7.4 5.2e-15 55.2 7.4 1.5 1 1 0 1 1 1 1 Sugar (and other) transporter DUF1129 PF06570.11 EXF84098.1 - 0.87 9.0 6.7 0.08 12.4 0.3 2.4 2 2 1 3 3 3 0 Protein of unknown function (DUF1129) EthD PF07110.11 EXF84100.1 - 6.4e-09 36.8 0.1 7.7e-09 36.6 0.1 1.1 1 0 0 1 1 1 1 EthD domain adh_short PF00106.25 EXF84101.1 - 8e-31 107.0 0.0 1.3e-22 80.2 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EXF84101.1 - 1.6e-20 73.7 0.1 2.3e-15 56.8 0.1 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF84101.1 - 3.2e-10 40.2 0.0 5e-10 39.6 0.0 1.3 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 EXF84101.1 - 0.012 15.6 0.1 0.047 13.6 0.3 1.9 2 0 0 2 2 2 0 NAD(P)H-binding adh_short PF00106.25 EXF84103.1 - 2e-28 99.2 0.2 1.9e-25 89.5 0.3 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EXF84103.1 - 3.3e-16 59.6 0.0 9.6e-15 54.8 0.0 2.0 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF84103.1 - 3.6e-07 30.3 0.0 6.2e-07 29.5 0.0 1.4 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EXF84103.1 - 1.2e-06 28.2 0.1 1.8e-06 27.6 0.1 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Shikimate_DH PF01488.20 EXF84103.1 - 0.046 13.8 0.1 0.084 12.9 0.1 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase NmrA PF05368.13 EXF84103.1 - 0.06 12.9 0.2 0.095 12.2 0.2 1.3 1 0 0 1 1 1 0 NmrA-like family NAD_binding_10 PF13460.6 EXF84103.1 - 0.084 12.8 0.2 0.13 12.2 0.2 1.4 1 1 0 1 1 1 0 NAD(P)H-binding eRF1_3 PF03465.15 EXF84103.1 - 0.085 13.3 0.1 0.4 11.2 0.1 2.1 2 0 0 2 2 2 0 eRF1 domain 3 GDP_Man_Dehyd PF16363.5 EXF84103.1 - 0.1 12.0 0.3 0.22 10.9 0.3 1.5 1 1 0 1 1 1 0 GDP-mannose 4,6 dehydratase MFS_1 PF07690.16 EXF84104.1 - 6.4e-37 127.3 44.7 2.8e-35 121.9 46.1 2.7 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EXF84104.1 - 8.9e-11 40.9 26.3 1.2e-10 40.4 26.3 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EXF84104.1 - 8.4e-09 34.8 32.5 5.1e-07 28.9 14.4 2.9 3 1 0 3 3 3 2 Sugar (and other) transporter DUF5305 PF17231.2 EXF84104.1 - 0.0018 17.7 0.2 0.99 8.8 0.0 2.5 2 0 0 2 2 2 2 Family of unknown function (DUF5305) TSA PF03249.13 EXF84104.1 - 0.056 12.2 0.1 0.097 11.4 0.1 1.3 1 0 0 1 1 1 0 Type specific antigen Ferric_reduct PF01794.19 EXF84105.1 - 6.8e-21 74.7 11.2 6.8e-21 74.7 11.2 2.2 2 0 0 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 EXF84105.1 - 0.0086 16.1 0.0 0.02 14.9 0.0 1.6 1 0 0 1 1 1 1 FAD-binding domain B_lectin PF01453.24 EXF84106.1 - 0.044 14.3 0.0 0.75 10.4 0.0 2.3 1 1 1 2 2 2 0 D-mannose binding lectin XPG_I_2 PF12813.7 EXF84107.1 - 1.3e-41 142.7 0.0 2.2e-41 142.0 0.0 1.3 1 0 0 1 1 1 1 XPG domain containing Pribosyltran_N PF13793.6 EXF84108.1 - 5.2e-43 145.7 0.2 4.5e-41 139.4 0.0 2.3 2 0 0 2 2 2 2 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 EXF84108.1 - 8.5e-35 120.4 0.0 4.3e-29 101.9 0.0 2.3 2 0 0 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 EXF84108.1 - 1.1e-08 34.7 0.0 0.00015 21.3 0.0 2.5 2 0 0 2 2 2 2 Phosphoribosyl transferase domain PAP_assoc PF03828.19 EXF84109.1 - 8.1e-17 61.2 0.1 7.9e-11 42.0 0.0 2.8 3 0 0 3 3 3 2 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 EXF84109.1 - 0.00054 20.2 0.0 0.0013 19.0 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyltransferase domain TFIIF_alpha PF05793.12 EXF84110.1 - 2.2e-07 29.9 58.5 2.2e-07 29.9 58.5 1.8 2 1 0 2 2 2 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Bud13 PF09736.9 EXF84111.1 - 5.7e-50 169.5 4.8 5.7e-50 169.5 4.8 2.5 2 1 0 2 2 2 1 Pre-mRNA-splicing factor of RES complex TRAPPC-Trs85 PF12739.7 EXF84112.1 - 1.1e-115 386.9 0.0 3.1e-115 385.4 0.0 1.6 2 0 0 2 2 2 1 ER-Golgi trafficking TRAPP I complex 85 kDa subunit Snf7 PF03357.21 EXF84113.1 - 1.5e-16 60.4 16.8 2.4e-16 59.8 16.8 1.3 1 0 0 1 1 1 1 Snf7 AAA_13 PF13166.6 EXF84113.1 - 0.66 8.5 12.0 1 8.0 12.0 1.2 1 0 0 1 1 1 0 AAA domain HAUS-augmin3 PF14932.6 EXF84113.1 - 0.83 9.2 14.8 0.16 11.6 4.3 2.3 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 3 zf-C3HC4_2 PF13923.6 EXF84114.1 - 2.9e-11 43.0 13.2 2.9e-11 43.0 13.2 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EXF84114.1 - 1.9e-07 30.9 19.9 4.1e-07 29.8 13.0 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EXF84114.1 - 7.5e-07 28.9 9.9 7.5e-07 28.9 9.9 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EXF84114.1 - 1.7e-06 28.0 10.8 1.7e-06 28.0 10.8 2.2 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_2 PF13639.6 EXF84114.1 - 1.2e-05 25.5 18.8 1.2e-05 25.5 12.7 2.3 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.6 EXF84114.1 - 1.5e-05 24.9 12.7 1.5e-05 24.9 12.7 2.2 2 0 0 2 2 2 1 zinc-RING finger domain SAP PF02037.27 EXF84114.1 - 3e-05 23.6 0.5 6.2e-05 22.6 0.1 1.8 2 0 0 2 2 2 1 SAP domain Prok-RING_4 PF14447.6 EXF84114.1 - 7.3e-05 22.5 14.5 0.0025 17.6 10.8 2.3 2 0 0 2 2 2 2 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 EXF84114.1 - 7.5e-05 22.8 12.4 7.5e-05 22.8 12.4 2.3 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_6 PF14835.6 EXF84114.1 - 0.00024 20.9 4.6 0.00024 20.9 4.6 1.9 2 0 0 2 2 2 1 zf-RING of BARD1-type protein zf-rbx1 PF12678.7 EXF84114.1 - 0.00055 20.2 6.4 0.00055 20.2 6.4 2.2 2 0 0 2 2 2 1 RING-H2 zinc finger domain U-box PF04564.15 EXF84114.1 - 0.0021 18.2 0.0 0.0051 17.0 0.0 1.6 1 0 0 1 1 1 1 U-box domain zf-RING_10 PF16685.5 EXF84114.1 - 0.017 15.2 7.2 0.034 14.3 7.2 1.5 1 0 0 1 1 1 0 zinc RING finger of MSL2 Mob_synth_C PF06463.13 EXF84114.1 - 0.068 13.1 4.8 0.17 11.8 4.8 1.6 1 0 0 1 1 1 0 Molybdenum Cofactor Synthesis C zf-Di19 PF05605.12 EXF84114.1 - 4 7.8 8.6 0.85 10.0 0.1 2.8 2 1 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-RING_4 PF14570.6 EXF84114.1 - 7.5 6.4 15.3 0.13 12.1 6.1 2.5 2 1 0 2 2 2 0 RING/Ubox like zinc-binding domain CDC27 PF09507.10 EXF84115.1 - 1.2e-82 278.6 24.4 3.6e-82 277.1 24.4 1.6 1 1 0 1 1 1 1 DNA polymerase subunit Cdc27 Glyco_hydro_125 PF06824.11 EXF84116.1 - 3.4e-178 592.8 0.0 3.9e-178 592.6 0.0 1.0 1 0 0 1 1 1 1 Metal-independent alpha-mannosidase (GH125) Pkinase PF00069.25 EXF84117.1 - 2.4e-42 145.1 0.0 5.5e-40 137.4 0.0 2.4 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EXF84117.1 - 1.1e-22 80.5 0.0 2.8e-22 79.3 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Aa_trans PF01490.18 EXF84118.1 - 1.6e-05 23.8 10.5 0.00053 18.8 4.3 2.1 1 1 1 2 2 2 2 Transmembrane amino acid transporter protein Glyco_hydro_71 PF03659.14 EXF84119.1 - 8.7e-120 400.0 5.6 2.3e-119 398.6 5.6 1.7 1 1 0 1 1 1 1 Glycosyl hydrolase family 71 Shisa PF13908.6 EXF84120.1 - 0.002 18.4 0.2 0.002 18.4 0.2 1.7 2 0 0 2 2 2 1 Wnt and FGF inhibitory regulator TMEM52 PF14979.6 EXF84120.1 - 0.016 15.1 1.2 0.036 14.0 1.2 1.5 1 0 0 1 1 1 0 Transmembrane 52 TMEM154 PF15102.6 EXF84120.1 - 0.067 13.1 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 TMEM154 protein family UPF0560 PF10577.9 EXF84120.1 - 0.073 11.6 0.2 0.096 11.2 0.2 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 CFEM PF05730.11 EXF84121.1 - 0.00017 21.6 3.1 0.00036 20.6 3.1 1.6 1 0 0 1 1 1 1 CFEM domain SKG6 PF08693.10 EXF84121.1 - 0.0065 15.9 0.0 0.014 14.8 0.0 1.6 1 0 0 1 1 1 1 Transmembrane alpha-helix domain ADH_zinc_N PF00107.26 EXF84122.1 - 2.1e-23 82.7 0.3 3.5e-23 82.0 0.3 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EXF84122.1 - 3.4e-20 72.0 0.1 8.1e-20 70.7 0.1 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 EXF84122.1 - 0.00012 23.1 0.1 0.0029 18.7 0.0 2.1 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Git3 PF11710.8 EXF84123.1 - 7.2e-22 78.2 7.1 1.1e-21 77.5 7.1 1.2 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 7tm_1 PF00001.21 EXF84123.1 - 2.3e-13 50.1 0.0 3.2e-13 49.6 0.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Dicty_CAR PF05462.11 EXF84123.1 - 2.8e-09 36.6 8.7 7.2e-08 31.9 6.2 2.1 2 0 0 2 2 2 2 Slime mold cyclic AMP receptor GPR_Gpa2_C PF11970.8 EXF84123.1 - 0.00049 20.1 0.4 0.0036 17.3 0.0 2.4 2 0 0 2 2 2 1 G protein-coupled glucose receptor regulating Gpa2 C-term Cu_amine_oxid PF01179.20 EXF84124.1 - 1.5e-121 406.1 3.4 1.9e-121 405.9 3.4 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain DUF1965 PF09248.10 EXF84124.1 - 7.5e-10 38.4 1.9 1.5e-09 37.5 0.1 2.5 3 0 0 3 3 3 1 Domain of unknown function (DUF1965) Cu_amine_oxidN2 PF02727.16 EXF84124.1 - 0.13 12.5 0.0 0.29 11.4 0.0 1.5 1 0 0 1 1 1 0 Copper amine oxidase, N2 domain MFS_1 PF07690.16 EXF84125.1 - 7.8e-20 71.1 29.5 1.6e-17 63.5 22.2 2.5 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 EXF84125.1 - 7.4e-08 31.6 3.7 0.00013 21.0 0.0 2.3 1 1 1 2 2 2 2 MFS_1 like family ketoacyl-synt PF00109.26 EXF84125.1 - 0.035 13.7 0.4 0.06 12.9 0.4 1.3 1 0 0 1 1 1 0 Beta-ketoacyl synthase, N-terminal domain EHN PF06441.12 EXF84126.1 - 2.2e-28 98.7 0.2 4.1e-28 97.9 0.2 1.5 1 0 0 1 1 1 1 Epoxide hydrolase N terminus Abhydrolase_1 PF00561.20 EXF84126.1 - 2.3e-06 27.4 0.1 3.4e-06 26.9 0.1 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold adh_short_C2 PF13561.6 EXF84127.1 - 2.1e-59 200.9 0.2 2.4e-59 200.7 0.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF84127.1 - 8e-47 159.2 0.5 9.9e-47 158.9 0.5 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EXF84127.1 - 1.4e-15 57.7 0.1 2.3e-15 57.0 0.1 1.2 1 0 0 1 1 1 1 KR domain 3Beta_HSD PF01073.19 EXF84127.1 - 0.00063 18.8 0.1 0.002 17.2 0.1 1.8 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family HATPase_c PF02518.26 EXF84127.1 - 0.055 14.0 0.0 0.14 12.7 0.0 1.7 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DLH PF01738.18 EXF84128.1 - 7.3e-28 97.6 0.0 8.6e-28 97.4 0.0 1.0 1 0 0 1 1 1 1 Dienelactone hydrolase family Zn_clus PF00172.18 EXF84129.1 - 3.4e-06 27.1 12.0 5.9e-06 26.3 12.0 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EXF84129.1 - 0.0022 17.1 0.3 0.0022 17.1 0.3 2.4 2 1 1 3 3 3 1 Fungal specific transcription factor domain YlbD_coat PF14071.6 EXF84129.1 - 0.044 14.0 0.0 0.46 10.7 0.0 2.3 2 0 0 2 2 2 0 Putative coat protein SnoaL PF07366.12 EXF84130.1 - 0.0074 16.1 0.0 0.014 15.2 0.0 1.5 1 0 0 1 1 1 1 SnoaL-like polyketide cyclase SnoaL_2 PF12680.7 EXF84130.1 - 0.096 13.3 0.0 0.23 12.1 0.0 1.6 1 0 0 1 1 1 0 SnoaL-like domain Pyr_redox_3 PF13738.6 EXF84131.1 - 2.4e-15 56.6 0.0 7.9e-15 54.9 0.0 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 EXF84131.1 - 6.8e-13 47.9 0.0 1.6e-11 43.3 0.0 2.1 2 0 0 2 2 2 1 Flavin-binding monooxygenase-like K_oxygenase PF13434.6 EXF84131.1 - 3.6e-12 46.1 0.0 1.1e-11 44.5 0.0 1.7 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.14 EXF84131.1 - 3.8e-08 32.9 0.0 1.6e-06 27.5 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EXF84131.1 - 0.00038 20.6 0.3 0.0088 16.3 0.0 2.6 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain NmrA PF05368.13 EXF84132.1 - 3.4e-15 56.3 0.0 4.2e-15 56.0 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EXF84132.1 - 2.1e-09 37.5 0.0 4.1e-09 36.6 0.0 1.4 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EXF84132.1 - 0.0013 18.2 0.0 0.0043 16.6 0.0 1.9 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family Metallophos PF00149.28 EXF84133.1 - 1.1e-12 48.9 0.1 1.5e-12 48.5 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EXF84133.1 - 0.044 14.0 0.0 0.089 13.0 0.0 1.6 2 0 0 2 2 2 0 Calcineurin-like phosphoesterase superfamily domain Methyltransf_23 PF13489.6 EXF84134.1 - 3.8e-17 62.6 0.0 8.8e-17 61.4 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF84134.1 - 1.1e-10 42.0 0.0 2.9e-10 40.7 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF84134.1 - 4.6e-10 39.5 0.0 1.8e-09 37.5 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF84134.1 - 3.2e-07 31.0 0.0 2.4e-06 28.2 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF84134.1 - 7.3e-07 29.8 0.0 1.7e-06 28.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_16 PF10294.9 EXF84134.1 - 0.00025 20.8 0.0 0.00037 20.3 0.0 1.3 1 0 0 1 1 1 1 Lysine methyltransferase MTS PF05175.14 EXF84134.1 - 0.00093 18.8 0.0 0.0062 16.1 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_2 PF00891.18 EXF84134.1 - 0.0047 16.2 0.0 0.01 15.2 0.0 1.5 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_4 PF02390.17 EXF84134.1 - 0.032 13.7 0.0 0.053 13.0 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase FtsJ PF01728.19 EXF84134.1 - 0.13 12.3 0.0 0.24 11.5 0.0 1.4 1 0 0 1 1 1 0 FtsJ-like methyltransferase PrmA PF06325.13 EXF84134.1 - 0.15 11.4 0.0 0.25 10.7 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) HET PF06985.11 EXF84135.1 - 2.6e-16 60.3 0.0 6.1e-16 59.1 0.0 1.7 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Ank_4 PF13637.6 EXF84136.1 - 2.8e-19 69.2 1.7 0.00082 19.9 0.0 4.7 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 EXF84136.1 - 1.5e-17 64.0 2.8 1.4e-07 32.0 0.1 4.0 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EXF84136.1 - 5.9e-12 45.6 1.0 7.8e-05 22.9 0.0 3.7 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 EXF84136.1 - 1.7e-09 37.7 9.5 0.066 13.7 0.2 6.0 5 1 0 5 5 5 3 Ankyrin repeat Ank_3 PF13606.6 EXF84136.1 - 1.4e-08 34.3 5.4 1.8 9.4 0.0 6.3 7 0 0 7 7 7 3 Ankyrin repeat Cu-oxidase_2 PF07731.14 EXF84138.1 - 1.8e-26 92.5 0.6 3.7e-24 85.0 0.7 2.6 2 0 0 2 2 2 2 Multicopper oxidase Cu-oxidase_3 PF07732.15 EXF84138.1 - 1.4e-17 63.8 0.1 4.2e-17 62.3 0.0 1.9 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase PF00394.22 EXF84138.1 - 0.00013 22.1 0.0 0.00034 20.8 0.0 1.8 1 1 0 1 1 1 1 Multicopper oxidase Sulfate_transp PF00916.20 EXF84139.1 - 5.1e-105 351.3 14.4 6.5e-105 351.0 14.4 1.1 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 EXF84139.1 - 1e-08 34.8 0.0 1.9e-08 33.9 0.0 1.4 1 0 0 1 1 1 1 STAS domain MFS_MOT1 PF16983.5 EXF84139.1 - 2.8e-07 30.9 14.3 2.4e-05 24.7 6.1 2.8 2 1 0 2 2 2 2 Molybdate transporter of MFS superfamily PMI_typeI PF01238.21 EXF84140.1 - 3.1e-72 243.9 0.0 1.5e-70 238.3 0.0 2.0 1 1 0 1 1 1 1 Phosphomannose isomerase type I Cupin_2 PF07883.11 EXF84140.1 - 4.2e-06 26.4 0.2 0.0069 16.1 0.1 2.6 2 0 0 2 2 2 2 Cupin domain AraC_binding PF02311.19 EXF84140.1 - 3e-05 23.9 0.0 0.00055 19.8 0.0 2.2 2 0 0 2 2 2 1 AraC-like ligand binding domain Cupin_3 PF05899.12 EXF84140.1 - 0.0025 17.5 0.4 0.06 13.0 0.2 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF861) GLTP PF08718.11 EXF84144.1 - 1.3e-47 161.8 0.0 1.7e-47 161.5 0.0 1.1 1 0 0 1 1 1 1 Glycolipid transfer protein (GLTP) ANTAR PF03861.14 EXF84145.1 - 0.091 12.6 0.3 0.2 11.5 0.3 1.6 1 0 0 1 1 1 0 ANTAR domain PLDc PF00614.22 EXF84146.1 - 3.9e-15 55.3 2.3 5.9e-07 29.4 0.1 2.7 2 0 0 2 2 2 2 Phospholipase D Active site motif PLDc_2 PF13091.6 EXF84146.1 - 6.8e-15 55.1 0.0 4.2e-05 23.4 0.0 3.6 3 0 0 3 3 3 3 PLD-like domain TPR_2 PF07719.17 EXF84147.1 - 1.2e-05 25.0 3.9 0.0045 17.0 0.0 3.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 EXF84147.1 - 8e-05 22.2 0.3 0.00018 21.1 0.3 1.6 1 0 0 1 1 1 1 TPR repeat TPR_12 PF13424.6 EXF84147.1 - 0.00013 22.2 0.3 0.00035 20.8 0.3 1.8 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.28 EXF84147.1 - 0.001 18.8 4.0 0.0093 15.8 0.1 3.4 4 1 1 5 5 5 1 Tetratricopeptide repeat Med2 PF11214.8 EXF84147.1 - 0.036 14.2 0.1 0.087 13.0 0.1 1.7 1 0 0 1 1 1 0 Mediator complex subunit 2 TPR_19 PF14559.6 EXF84147.1 - 0.052 14.1 1.5 0.093 13.2 0.1 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 EXF84147.1 - 0.51 11.3 5.1 0.7 10.9 0.0 3.3 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 EXF84147.1 - 3.8 8.2 10.7 1.7 9.4 0.6 3.1 2 1 0 2 2 2 0 Tetratricopeptide repeat HAD_2 PF13419.6 EXF84148.1 - 5.5e-17 62.4 0.0 2.5e-08 34.2 0.0 2.2 1 1 1 2 2 2 2 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EXF84148.1 - 1.2e-06 29.0 0.0 6.4e-05 23.3 0.0 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EXF84148.1 - 0.0011 19.0 0.0 0.002 18.1 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like NT5C PF06941.12 EXF84148.1 - 0.044 13.7 0.0 0.18 11.6 0.0 2.0 1 1 0 1 1 1 0 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) Fungal_trans_2 PF11951.8 EXF84149.1 - 5.4e-09 35.3 0.0 1.4e-08 34.0 0.0 1.7 1 1 0 1 1 1 1 Fungal specific transcription factor domain Pantoate_ligase PF02569.15 EXF84150.1 - 3.1e-93 311.8 0.0 3.8e-93 311.5 0.0 1.1 1 0 0 1 1 1 1 Pantoate-beta-alanine ligase Acyltransferase PF01553.21 EXF84151.1 - 5.6e-17 61.6 0.0 1.1e-16 60.7 0.0 1.4 1 0 0 1 1 1 1 Acyltransferase RAP PF08373.10 EXF84151.1 - 0.13 12.4 0.0 0.33 11.1 0.0 1.6 1 0 0 1 1 1 0 RAP domain UPF0086 PF01868.16 EXF84152.1 - 4.3e-28 97.1 0.0 6.3e-28 96.5 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function UPF0086 ECM1 PF05782.11 EXF84153.1 - 3.8 6.3 15.4 5.2 5.9 15.4 1.1 1 0 0 1 1 1 0 Extracellular matrix protein 1 (ECM1) adh_short_C2 PF13561.6 EXF84154.1 - 2.4e-52 177.8 0.0 2.8e-52 177.6 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF84154.1 - 3e-45 154.1 0.0 3.6e-45 153.8 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EXF84154.1 - 2.2e-12 47.3 0.0 3.1e-12 46.8 0.0 1.1 1 0 0 1 1 1 1 KR domain THF_DHG_CYH_C PF02882.19 EXF84154.1 - 0.02 14.2 0.0 0.038 13.3 0.0 1.5 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain tRNA-synt_1b PF00579.25 EXF84155.1 - 6.1e-19 68.4 0.0 1.1e-18 67.5 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) Pterin_bind PF00809.22 EXF84155.1 - 0.13 11.9 0.0 0.66 9.6 0.0 1.9 2 0 0 2 2 2 0 Pterin binding enzyme HET PF06985.11 EXF84156.1 - 5.2e-20 72.3 0.0 9.2e-20 71.5 0.0 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Pkinase PF00069.25 EXF84157.1 - 2.6e-47 161.4 0.0 6e-25 88.1 0.0 3.3 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 EXF84157.1 - 7.7e-34 117.1 0.0 8.2e-19 67.9 0.0 2.8 2 1 0 2 2 2 2 Protein tyrosine kinase Pox_ser-thr_kin PF05445.11 EXF84157.1 - 0.035 13.1 0.0 2.5 7.0 0.0 2.5 2 0 0 2 2 2 0 Poxvirus serine/threonine protein kinase APH PF01636.23 EXF84157.1 - 0.072 13.0 0.6 5.9 6.7 0.0 2.6 2 1 0 2 2 2 0 Phosphotransferase enzyme family Fungal_trans PF04082.18 EXF84159.1 - 3.5e-05 23.0 0.0 0.085 11.9 0.0 2.2 1 1 1 2 2 2 2 Fungal specific transcription factor domain Abhydrolase_6 PF12697.7 EXF84160.1 - 3.2e-15 57.4 0.0 4.6e-15 56.8 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EXF84160.1 - 3.5e-10 40.0 0.1 5.5e-10 39.3 0.1 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EXF84160.1 - 3.9e-06 26.3 0.0 5.4e-06 25.9 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 PGAP1 PF07819.13 EXF84160.1 - 0.0027 17.5 0.0 0.0063 16.3 0.0 1.6 2 0 0 2 2 2 1 PGAP1-like protein Ndr PF03096.14 EXF84160.1 - 0.011 14.5 0.0 0.032 12.9 0.0 1.6 2 0 0 2 2 2 0 Ndr family Ser_hydrolase PF06821.13 EXF84160.1 - 0.023 14.6 0.0 0.048 13.5 0.0 1.5 1 0 0 1 1 1 0 Serine hydrolase DUF1057 PF06342.12 EXF84160.1 - 0.06 12.4 0.1 0.21 10.6 0.0 1.8 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF1057) HpcH_HpaI PF03328.14 EXF84161.1 - 6.1e-24 84.4 0.0 1.5e-20 73.3 0.0 2.1 1 1 1 2 2 2 2 HpcH/HpaI aldolase/citrate lyase family MFS_1 PF07690.16 EXF84162.1 - 5e-24 84.9 17.1 6.6e-24 84.5 17.1 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily COesterase PF00135.28 EXF84163.1 - 1.5e-75 255.1 0.0 2e-75 254.6 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family DUF3176 PF11374.8 EXF84163.1 - 2.4e-33 114.5 1.0 6.3e-33 113.2 1.0 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF3176) Abhydrolase_3 PF07859.13 EXF84163.1 - 2.1e-06 27.7 0.0 0.0094 15.8 0.0 2.5 2 0 0 2 2 2 2 alpha/beta hydrolase fold Lactate_perm PF02652.14 EXF84163.1 - 0.13 11.0 0.2 0.19 10.4 0.2 1.1 1 0 0 1 1 1 0 L-lactate permease Aminotran_1_2 PF00155.21 EXF84164.1 - 5.6e-14 52.1 0.0 2.1e-13 50.2 0.0 1.8 1 1 0 1 1 1 1 Aminotransferase class I and II Transp_cyt_pur PF02133.15 EXF84165.1 - 1.8e-77 261.0 38.0 2e-77 260.8 38.0 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin COX14 PF14880.6 EXF84165.1 - 2.9 7.8 4.3 2 8.3 0.0 2.6 2 0 0 2 2 2 0 Cytochrome oxidase c assembly Fungal_trans_2 PF11951.8 EXF84166.1 - 1.1e-24 87.0 0.1 1.7e-24 86.4 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF84166.1 - 7.7e-08 32.3 8.3 1.3e-07 31.6 8.3 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain EphA2_TM PF14575.6 EXF84167.1 - 9.5e-06 26.4 0.0 1.2e-05 26.0 0.0 1.3 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain SARAF PF06682.12 EXF84167.1 - 1.6e-05 24.7 0.7 1.7e-05 24.6 0.7 1.1 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis Adeno_E3_CR2 PF02439.15 EXF84167.1 - 0.00022 20.9 4.7 0.00033 20.3 4.7 1.2 1 0 0 1 1 1 1 Adenovirus E3 region protein CR2 RIFIN PF02009.16 EXF84167.1 - 0.0026 17.7 0.2 0.0036 17.2 0.2 1.1 1 0 0 1 1 1 1 Rifin GRP PF07172.11 EXF84167.1 - 0.0028 18.3 6.2 0.0044 17.7 6.2 1.3 1 0 0 1 1 1 1 Glycine rich protein family DAG1 PF05454.11 EXF84167.1 - 0.018 14.4 0.3 0.024 14.0 0.3 1.2 1 0 0 1 1 1 0 Dystroglycan (Dystrophin-associated glycoprotein 1) Amnionless PF14828.6 EXF84167.1 - 0.024 13.5 0.0 0.026 13.4 0.0 1.0 1 0 0 1 1 1 0 Amnionless Herpes_gE PF02480.16 EXF84167.1 - 0.058 12.1 0.0 0.064 12.0 0.0 1.1 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E DUF4690 PF15756.5 EXF84167.1 - 0.069 13.8 0.8 0.12 12.9 0.8 1.5 1 0 0 1 1 1 0 Small Novel Rich in Cartilage Shisa PF13908.6 EXF84167.1 - 0.13 12.5 0.0 0.16 12.2 0.0 1.3 1 1 0 1 1 1 0 Wnt and FGF inhibitory regulator Syndecan PF01034.20 EXF84167.1 - 1 9.3 4.4 2.2 8.3 4.4 1.5 1 0 0 1 1 1 0 Syndecan domain Glyco_hydro_76 PF03663.14 EXF84168.1 - 7.7e-141 469.9 7.0 9.7e-141 469.5 7.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Helo_like_N PF17111.5 EXF84169.1 - 2.7e-07 30.2 0.4 5.3e-07 29.2 0.4 1.5 1 0 0 1 1 1 1 Fungal N-terminal domain of STAND proteins EloA-BP1 PF15870.5 EXF84169.1 - 0.05 13.9 1.5 0.24 11.6 1.5 2.0 1 1 1 2 2 2 0 ElonginA binding-protein 1 SesA PF17107.5 EXF84169.1 - 0.077 13.2 0.4 0.24 11.6 0.0 2.1 2 0 0 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases HET PF06985.11 EXF84170.1 - 1.5e-24 87.0 0.0 3.2e-24 86.0 0.0 1.6 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) OPT PF03169.15 EXF84171.1 - 1.4e-81 275.0 49.4 1.7e-81 274.8 49.4 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein GFA PF04828.14 EXF84172.1 - 0.0078 16.5 1.2 0.0078 16.5 1.2 3.1 3 1 1 4 4 4 2 Glutathione-dependent formaldehyde-activating enzyme Cupin_2 PF07883.11 EXF84173.1 - 1.1e-14 53.8 0.1 2e-14 53.0 0.1 1.4 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.19 EXF84173.1 - 7.3e-05 22.7 0.0 0.00011 22.2 0.0 1.2 1 0 0 1 1 1 1 AraC-like ligand binding domain ARD PF03079.14 EXF84173.1 - 0.00013 22.2 0.3 0.00029 21.1 0.0 1.6 2 0 0 2 2 2 1 ARD/ARD' family Cupin_1 PF00190.22 EXF84173.1 - 0.00028 20.5 0.0 0.00038 20.1 0.0 1.2 1 0 0 1 1 1 1 Cupin Cupin_6 PF12852.7 EXF84173.1 - 0.0037 17.0 0.0 0.0045 16.7 0.0 1.2 1 0 0 1 1 1 1 Cupin JmjC PF02373.22 EXF84173.1 - 0.0067 16.9 0.0 0.012 16.1 0.0 1.4 1 0 0 1 1 1 1 JmjC domain, hydroxylase Cupin_3 PF05899.12 EXF84173.1 - 0.0088 15.7 0.0 0.017 14.8 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF861) FA_desaturase PF00487.24 EXF84174.1 - 1.1e-13 51.6 26.8 1.8e-13 50.9 26.8 1.3 1 0 0 1 1 1 1 Fatty acid desaturase Hydrolase_4 PF12146.8 EXF84177.1 - 7.6e-05 22.1 0.0 0.00011 21.6 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 BAAT_C PF08840.11 EXF84177.1 - 0.00013 22.0 0.0 0.0002 21.4 0.0 1.3 1 0 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal DLH PF01738.18 EXF84177.1 - 0.00018 21.1 0.0 0.00062 19.4 0.0 1.7 1 1 0 1 1 1 1 Dienelactone hydrolase family Peptidase_S9 PF00326.21 EXF84177.1 - 0.0014 18.1 0.0 0.0027 17.2 0.0 1.5 1 0 0 1 1 1 1 Prolyl oligopeptidase family COesterase PF00135.28 EXF84178.1 - 1.3e-78 265.1 0.0 1.8e-78 264.7 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EXF84178.1 - 0.0044 16.9 0.4 0.018 14.9 0.4 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Endopep_inhib PF16800.5 EXF84178.1 - 0.028 14.4 0.1 0.11 12.4 0.1 1.9 2 0 0 2 2 2 0 IseA DL-endopeptidase inhibitor GFO_IDH_MocA PF01408.22 EXF84179.1 - 6.4e-14 52.8 0.2 1.3e-13 51.9 0.2 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold NmrA PF05368.13 EXF84180.1 - 1e-17 64.5 2.1 6.5e-17 61.9 2.1 2.0 1 1 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EXF84180.1 - 1.6e-12 47.7 1.1 1.3e-11 44.7 1.1 2.4 1 1 0 1 1 1 1 NAD(P)H-binding DapB_N PF01113.20 EXF84180.1 - 0.012 15.7 0.2 0.039 14.1 0.2 1.9 1 1 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus KR PF08659.10 EXF84180.1 - 0.057 13.3 0.0 0.092 12.6 0.0 1.4 1 0 0 1 1 1 0 KR domain IKI3 PF04762.12 EXF84180.1 - 0.11 10.4 0.0 0.16 10.0 0.0 1.1 1 0 0 1 1 1 0 IKI3 family FAD_binding_4 PF01565.23 EXF84181.1 - 4.8e-26 91.2 0.4 8e-26 90.4 0.4 1.4 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EXF84181.1 - 0.00082 19.4 1.8 0.0017 18.4 0.1 2.2 2 0 0 2 2 2 1 Berberine and berberine like GMC_oxred_N PF00732.19 EXF84182.1 - 6.9e-57 193.1 0.0 9e-57 192.7 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EXF84182.1 - 4.1e-33 114.9 0.0 6.9e-33 114.2 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.24 EXF84182.1 - 9.9e-07 28.2 0.3 0.027 13.5 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 EXF84182.1 - 0.0002 21.5 0.1 0.00068 19.8 0.1 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EXF84182.1 - 0.00054 19.6 0.3 0.0097 15.5 0.0 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EXF84182.1 - 0.0051 16.1 0.2 0.12 11.6 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EXF84182.1 - 0.018 14.1 0.0 0.039 13.0 0.0 1.6 1 0 0 1 1 1 0 Lycopene cyclase protein Thi4 PF01946.17 EXF84182.1 - 0.024 13.9 0.0 0.053 12.8 0.0 1.5 1 0 0 1 1 1 0 Thi4 family NAD_binding_9 PF13454.6 EXF84182.1 - 0.054 13.5 0.0 0.13 12.2 0.0 1.6 1 0 0 1 1 1 0 FAD-NAD(P)-binding MFS_1 PF07690.16 EXF84184.1 - 6.2e-16 58.3 20.7 6.7e-08 31.8 0.2 2.8 1 1 1 2 2 2 2 Major Facilitator Superfamily HemY_N PF07219.13 EXF84184.1 - 0.077 13.2 0.4 0.23 11.7 0.1 1.9 2 0 0 2 2 2 0 HemY protein N-terminus DUF3302 PF11742.8 EXF84184.1 - 0.54 10.4 3.8 21 5.3 0.1 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3302) TraL PF07178.11 EXF84184.1 - 2.7 8.5 5.9 1.9 9.0 0.3 3.1 3 1 0 3 3 3 0 TraL protein HIG_1_N PF04588.13 EXF84184.1 - 3.8 7.8 6.0 29 5.0 1.3 2.7 2 0 0 2 2 2 0 Hypoxia induced protein conserved region DIOX_N PF14226.6 EXF84185.1 - 3.8e-20 72.8 0.0 8.6e-20 71.7 0.0 1.5 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EXF84185.1 - 4.6e-14 52.7 0.0 8.6e-14 51.9 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 EXF84186.1 - 5.5e-34 117.4 0.0 1.1e-33 116.5 0.0 1.5 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EXF84186.1 - 3.7e-13 49.8 0.0 6.3e-13 49.1 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Peptidase_M6 PF05547.11 EXF84187.1 - 7.7e-07 27.8 0.2 0.0024 16.3 0.9 2.1 2 0 0 2 2 2 2 Immune inhibitor A peptidase M6 Cellulase PF00150.18 EXF84188.1 - 9.5e-47 159.8 0.9 1.4e-46 159.2 0.9 1.1 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) CBM_1 PF00734.18 EXF84188.1 - 1.4e-10 40.9 8.4 1.4e-10 40.9 8.4 2.5 2 0 0 2 2 2 1 Fungal cellulose binding domain ChiC PF06483.11 EXF84189.1 - 0.024 14.6 0.0 0.025 14.5 0.0 1.1 1 0 0 1 1 1 0 Chitinase C Itfg2 PF15907.5 EXF84190.1 - 0.027 13.5 0.0 0.034 13.2 0.0 1.2 1 0 0 1 1 1 0 Integrin-alpha FG-GAP repeat-containing protein 2 Peptidase_S41 PF03572.18 EXF84191.1 - 4.3e-08 32.9 0.0 8.3e-08 32.0 0.0 1.5 1 0 0 1 1 1 1 Peptidase family S41 Paramyxo_PNT PF14320.6 EXF84191.1 - 0.059 12.5 0.1 0.087 12.0 0.1 1.2 1 0 0 1 1 1 0 Phosphoprotein P region PNT disordered GATase PF00117.28 EXF84192.1 - 1.3e-09 38.1 0.0 2.5e-09 37.2 0.0 1.4 2 0 0 2 2 2 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 EXF84192.1 - 0.016 14.9 0.0 0.48 10.1 0.0 2.3 1 1 0 1 1 1 0 Peptidase C26 Fungal_trans_2 PF11951.8 EXF84193.1 - 0.006 15.4 1.6 0.007 15.2 0.4 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain MDM10 PF12519.8 EXF84194.1 - 2.7e-173 577.2 0.0 3e-173 577.0 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial distribution and morphology protein 10 Porin_3 PF01459.22 EXF84194.1 - 0.005 16.3 0.0 2 7.8 0.0 2.6 2 0 0 2 2 2 2 Eukaryotic porin Zip PF02535.22 EXF84195.1 - 8.6e-58 196.1 9.6 9.9e-58 195.9 9.6 1.0 1 0 0 1 1 1 1 ZIP Zinc transporter Ribosomal_S19e PF01090.19 EXF84196.1 - 1e-59 200.1 0.1 1.2e-59 200.0 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S19e MFS_1 PF07690.16 EXF84198.1 - 2.9e-49 167.9 44.9 4.6e-48 164.0 29.0 1.7 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF84198.1 - 1.4e-12 47.3 8.4 1.4e-12 47.3 8.4 2.5 1 1 1 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 EXF84198.1 - 9.2e-08 31.0 0.4 1.7e-07 30.0 0.4 1.4 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) OATP PF03137.20 EXF84198.1 - 0.47 8.7 9.0 0.9 7.7 0.9 3.2 3 0 0 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family 4HBT PF03061.22 EXF84199.1 - 6.7e-15 55.2 0.0 9.8e-15 54.7 0.0 1.2 1 0 0 1 1 1 1 Thioesterase superfamily Zn_clus PF00172.18 EXF84200.1 - 9.2e-08 32.1 7.5 9.2e-08 32.1 7.5 1.6 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EXF84200.1 - 4.8e-05 22.4 0.9 0.0002 20.3 0.2 1.9 2 0 0 2 2 2 1 Fungal specific transcription factor domain Polysacc_deac_1 PF01522.21 EXF84202.1 - 3.8e-30 104.3 0.0 5.7e-30 103.8 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase Glyco_hydro_57 PF03065.15 EXF84202.1 - 0.0011 18.3 0.0 0.0044 16.3 0.0 1.6 1 1 0 1 1 1 1 Glycosyl hydrolase family 57 Glyco_hydro_114 PF03537.13 EXF84202.1 - 0.0063 15.9 0.0 0.024 14.0 0.0 1.8 2 0 0 2 2 2 1 Glycoside-hydrolase family GH114 Glyco_hydro_18 PF00704.28 EXF84203.1 - 4.2e-67 227.1 0.1 4.8e-67 226.9 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 DUF3142 PF11340.8 EXF84203.1 - 0.019 14.8 0.0 0.035 13.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3142) Ricin_B_lectin PF00652.22 EXF84204.1 - 3.3e-15 56.5 0.1 1.8e-05 25.0 0.0 4.2 2 2 2 4 4 4 4 Ricin-type beta-trefoil lectin domain RicinB_lectin_2 PF14200.6 EXF84204.1 - 4.7e-05 24.0 1.0 0.95 10.2 0.0 3.7 3 1 0 3 3 3 2 Ricin-type beta-trefoil lectin domain-like CDtoxinA PF03498.14 EXF84204.1 - 0.092 12.3 6.2 2.3 7.8 0.2 3.6 2 2 1 4 4 4 0 Cytolethal distending toxin A/C domain CorA PF01544.18 EXF84205.1 - 5.1e-28 98.2 10.4 1e-23 84.1 7.8 3.0 2 1 0 2 2 2 2 CorA-like Mg2+ transporter protein LapA_dom PF06305.11 EXF84205.1 - 0.0073 16.1 0.4 0.018 14.9 0.4 1.7 1 0 0 1 1 1 1 Lipopolysaccharide assembly protein A domain DUF4282 PF14110.6 EXF84205.1 - 0.075 13.8 1.5 0.16 12.7 1.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4282) adh_short PF00106.25 EXF84207.1 - 3.9e-39 134.1 1.1 5.5e-39 133.6 1.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF84207.1 - 3.7e-30 105.2 0.4 5.1e-30 104.8 0.4 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF84207.1 - 7.1e-11 42.3 6.2 9.3e-10 38.7 6.2 2.1 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 EXF84207.1 - 2e-06 27.4 1.1 4.4e-06 26.3 1.1 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EXF84207.1 - 3.4e-05 23.4 0.2 9.9e-05 21.9 0.1 1.8 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 EXF84207.1 - 0.0002 21.3 0.1 0.00031 20.7 0.1 1.4 1 0 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 EXF84207.1 - 0.0004 19.5 0.2 0.00058 18.9 0.2 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 EXF84207.1 - 0.0034 16.5 0.1 0.0056 15.8 0.1 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain TrkA_N PF02254.18 EXF84207.1 - 0.024 14.9 0.1 0.048 13.9 0.1 1.5 1 0 0 1 1 1 0 TrkA-N domain 3HCDH_N PF02737.18 EXF84207.1 - 0.046 13.6 0.1 0.084 12.7 0.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ApbA PF02558.16 EXF84207.1 - 0.063 12.9 0.5 0.29 10.8 0.3 2.0 1 1 1 2 2 2 0 Ketopantoate reductase PanE/ApbA NmrA PF05368.13 EXF84207.1 - 0.095 12.2 0.3 0.16 11.5 0.3 1.4 1 0 0 1 1 1 0 NmrA-like family Gp_dh_N PF00044.24 EXF84207.1 - 0.12 12.7 0.1 0.22 11.9 0.1 1.5 1 0 0 1 1 1 0 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain Polysacc_synt_2 PF02719.15 EXF84207.1 - 0.13 11.3 0.0 0.24 10.5 0.0 1.4 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein BOP1NT PF08145.12 EXF84209.1 - 9.7e-106 353.4 7.8 1.5e-105 352.8 7.8 1.3 1 0 0 1 1 1 1 BOP1NT (NUC169) domain WD40 PF00400.32 EXF84209.1 - 2.1e-22 79.0 5.3 2.2e-10 40.9 0.4 6.0 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EXF84209.1 - 2.1e-06 27.9 0.1 0.0029 17.9 0.0 4.5 3 2 2 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain Zn_clus PF00172.18 EXF84210.1 - 4.7e-07 29.8 10.1 9.5e-07 28.8 10.1 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Utp21 PF04192.12 EXF84210.1 - 0.02 14.4 0.0 0.075 12.5 0.0 1.8 2 0 0 2 2 2 0 Utp21 specific WD40 associated putative domain DUF3446 PF11928.8 EXF84210.1 - 7.5 6.9 10.0 0.68 10.3 2.9 2.7 3 0 0 3 3 3 0 Early growth response N-terminal domain STIMATE PF12400.8 EXF84211.1 - 1e-40 139.1 4.3 1e-40 139.1 4.3 1.6 2 0 0 2 2 2 1 STIMATE family Virul_fac_BrkB PF03631.15 EXF84211.1 - 6 6.4 12.6 2.1 7.9 0.9 2.4 2 1 0 2 2 2 0 Virulence factor BrkB Methyltransf_23 PF13489.6 EXF84212.1 - 1.4e-19 70.6 0.0 2.5e-19 69.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF84212.1 - 1.4e-06 28.9 0.0 8.8e-06 26.4 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF84212.1 - 0.00077 20.2 0.0 0.0045 17.7 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF84212.1 - 0.00095 19.0 0.1 0.013 15.3 0.1 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF84212.1 - 0.0069 17.0 0.0 0.048 14.3 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Sterol_MT_C PF08498.10 EXF84212.1 - 0.084 13.2 0.0 0.2 12.0 0.0 1.7 1 0 0 1 1 1 0 Sterol methyltransferase C-terminal PCMT PF01135.19 EXF84212.1 - 0.16 11.7 0.0 0.45 10.2 0.0 1.7 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_23 PF13489.6 EXF84213.1 - 2.1e-38 131.7 0.0 2.8e-20 72.8 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_25 PF13649.6 EXF84213.1 - 8.8e-22 77.6 0.0 5.6e-10 39.8 0.0 2.9 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_31 PF13847.6 EXF84213.1 - 1.1e-17 64.2 0.0 7.4e-08 32.3 0.0 3.7 2 2 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 EXF84213.1 - 2.2e-16 60.4 0.0 1.2e-06 29.2 0.0 3.2 2 2 0 2 2 2 2 Methyltransferase domain Methyltransf_11 PF08241.12 EXF84213.1 - 3.1e-14 53.4 0.0 1.7e-05 25.4 0.0 2.8 2 0 0 2 2 2 2 Methyltransferase domain MTS PF05175.14 EXF84213.1 - 3.3e-07 30.0 0.5 0.079 12.5 0.0 4.3 6 0 0 6 6 6 2 Methyltransferase small domain Methyltransf_4 PF02390.17 EXF84213.1 - 3.4e-07 29.9 0.7 0.25 10.8 0.0 3.6 3 0 0 3 3 3 2 Putative methyltransferase FtsJ PF01728.19 EXF84213.1 - 8.2e-07 29.3 0.0 0.028 14.5 0.0 2.4 2 0 0 2 2 2 2 FtsJ-like methyltransferase PrmA PF06325.13 EXF84213.1 - 0.00024 20.6 0.0 0.097 12.0 0.0 2.5 2 0 0 2 2 2 2 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_16 PF10294.9 EXF84213.1 - 0.00035 20.4 0.0 0.44 10.3 0.0 2.8 3 0 0 3 3 3 2 Lysine methyltransferase Ubie_methyltran PF01209.18 EXF84213.1 - 0.0011 18.4 0.0 1.5 8.1 0.0 3.5 2 2 0 2 2 2 2 ubiE/COQ5 methyltransferase family Methyltransf_17 PF12692.7 EXF84213.1 - 0.028 14.4 0.0 9.9 6.1 0.0 3.5 4 0 0 4 4 4 0 S-adenosyl-L-methionine methyltransferase Methyltransf_2 PF00891.18 EXF84213.1 - 0.031 13.6 0.4 8.1 5.7 0.0 3.1 3 0 0 3 3 3 0 O-methyltransferase domain CopK PF11525.8 EXF84213.1 - 0.15 11.7 0.1 28 4.4 0.0 2.6 2 0 0 2 2 2 0 Copper resistance protein K Methyltransf_23 PF13489.6 EXF84214.1 - 3.3e-21 75.8 0.0 4.6e-21 75.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF84214.1 - 5.2e-10 39.9 0.0 1.2e-09 38.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF84214.1 - 1.4e-07 31.4 0.0 2.4e-06 27.4 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF84214.1 - 3.7e-07 30.7 0.0 7e-07 29.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF84214.1 - 7.7e-07 29.8 0.0 3.6e-06 27.6 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 EXF84214.1 - 0.0018 17.8 0.0 0.003 17.1 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase PrmA PF06325.13 EXF84214.1 - 0.016 14.6 0.0 0.025 14.0 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 EXF84214.1 - 0.039 13.5 0.0 0.067 12.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain CMAS PF02353.20 EXF84214.1 - 0.065 12.5 0.0 0.17 11.1 0.0 1.7 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase PCMT PF01135.19 EXF84214.1 - 0.083 12.6 0.0 0.35 10.6 0.0 2.0 2 1 0 2 2 2 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MSA-2c PF12238.8 EXF84214.1 - 1.3 9.0 4.0 1.9 8.4 4.0 1.3 1 0 0 1 1 1 0 Merozoite surface antigen 2c Methyltransf_23 PF13489.6 EXF84215.1 - 1.3e-20 73.8 0.0 2.3e-20 73.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF84215.1 - 2.3e-09 37.8 0.0 5.3e-09 36.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF84215.1 - 2.4e-07 30.7 0.0 0.00047 20.0 0.0 2.1 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_11 PF08241.12 EXF84215.1 - 1.4e-05 25.7 0.0 2.7e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF84215.1 - 2.1e-05 25.2 0.0 0.00013 22.6 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EXF84215.1 - 0.014 14.9 0.0 0.027 14.0 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain PrmA PF06325.13 EXF84215.1 - 0.033 13.6 0.0 0.05 13.0 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_4 PF02390.17 EXF84215.1 - 0.034 13.6 0.0 0.067 12.7 0.0 1.4 1 0 0 1 1 1 0 Putative methyltransferase GidB PF02527.15 EXF84215.1 - 0.11 11.8 0.0 0.17 11.2 0.0 1.2 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G Methyltransf_23 PF13489.6 EXF84216.1 - 1.6e-20 73.6 0.0 2.2e-20 73.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF84216.1 - 5.7e-10 39.8 0.0 1.1e-09 38.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF84216.1 - 2e-07 31.6 0.0 3.5e-07 30.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF84216.1 - 3.2e-05 23.8 0.0 0.00026 20.8 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF84216.1 - 8.9e-05 23.2 0.0 0.00025 21.7 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EXF84216.1 - 0.0016 17.8 0.0 0.29 10.4 0.0 2.8 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family FtsJ PF01728.19 EXF84216.1 - 0.0087 16.2 0.0 0.011 15.8 0.0 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase COesterase PF00135.28 EXF84218.1 - 2.1e-89 300.8 0.0 2.6e-89 300.4 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EXF84218.1 - 0.0066 16.3 0.1 0.02 14.7 0.0 1.7 2 0 0 2 2 2 1 alpha/beta hydrolase fold F-box-like PF12937.7 EXF84219.1 - 5.5e-06 26.2 0.2 1.2e-05 25.1 0.2 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EXF84219.1 - 0.0022 17.8 0.0 0.0063 16.4 0.0 1.8 1 0 0 1 1 1 1 F-box domain DUF4677 PF15726.5 EXF84220.1 - 0.22 11.6 1.0 0.31 11.2 1.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4677) WSC PF01822.19 EXF84221.1 - 2.1e-17 63.1 7.9 2.6e-17 62.8 7.9 1.1 1 0 0 1 1 1 1 WSC domain IMS PF00817.20 EXF84222.1 - 1.2e-40 139.0 0.0 2.7e-40 137.8 0.0 1.6 1 0 0 1 1 1 1 impB/mucB/samB family REV1_C PF16727.5 EXF84222.1 - 2.5e-28 98.3 1.8 6.2e-28 97.0 1.8 1.7 1 0 0 1 1 1 1 DNA repair protein REV1 C-terminal domain IMS_C PF11799.8 EXF84222.1 - 7.3e-13 49.3 0.0 1.7e-12 48.0 0.0 1.6 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain UBM PF14377.6 EXF84222.1 - 5.5e-12 44.7 7.9 2.2e-05 23.8 0.0 3.9 4 0 0 4 4 4 3 Ubiquitin binding region BRCT_2 PF16589.5 EXF84222.1 - 1e-05 25.8 0.0 2.7e-05 24.5 0.0 1.8 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain mCpol PF18182.1 EXF84222.1 - 0.0052 17.1 0.0 0.015 15.7 0.0 1.8 1 0 0 1 1 1 1 minimal CRISPR polymerase domain LIG3_BRCT PF16759.5 EXF84222.1 - 0.009 16.3 0.0 0.021 15.1 0.0 1.6 1 0 0 1 1 1 1 DNA ligase 3 BRCT domain DUF1805 PF08827.11 EXF84222.1 - 0.0094 16.3 0.1 0.12 12.7 0.0 2.8 3 0 0 3 3 3 1 Domain of unknown function (DUF1805) MgtE_N PF03448.17 EXF84222.1 - 0.015 15.9 0.4 7.9 7.2 0.2 3.5 3 0 0 3 3 3 0 MgtE intracellular N domain F420_ligase PF01996.16 EXF84222.1 - 0.07 12.5 0.0 0.11 11.8 0.0 1.4 1 0 0 1 1 1 0 F420-0:Gamma-glutamyl ligase IMS_HHH PF11798.8 EXF84222.1 - 0.18 12.2 0.2 1.3 9.5 0.0 2.6 2 0 0 2 2 2 0 IMS family HHH motif RED_N PF07808.13 EXF84223.1 - 3.1e-07 30.2 17.6 3.1e-07 30.2 17.6 2.9 2 1 1 3 3 3 1 RED-like protein N-terminal region IU_nuc_hydro PF01156.19 EXF84224.1 - 7.3e-85 285.2 0.1 8.7e-85 284.9 0.1 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase Bac_rhodopsin PF01036.18 EXF84225.1 - 5.5e-32 111.1 22.8 7.4e-32 110.7 22.8 1.0 1 0 0 1 1 1 1 Bacteriorhodopsin-like protein MCLC PF05934.11 EXF84225.1 - 5.4 5.6 5.6 7 5.3 5.6 1.1 1 0 0 1 1 1 0 Mid-1-related chloride channel (MCLC) Arm PF00514.23 EXF84226.1 - 3.8e-12 45.8 3.5 0.048 13.7 0.0 6.9 6 0 0 6 6 6 2 Armadillo/beta-catenin-like repeat HEAT PF02985.22 EXF84226.1 - 0.0001 22.2 10.1 26 5.4 0.0 7.2 6 0 0 6 6 6 0 HEAT repeat HEAT_EZ PF13513.6 EXF84226.1 - 0.00058 20.3 12.7 0.074 13.6 0.0 6.3 6 0 0 6 6 6 2 HEAT-like repeat TIMELESS PF04821.14 EXF84226.1 - 0.0011 18.4 2.8 0.79 8.9 0.0 3.8 4 0 0 4 4 4 2 Timeless protein DUF3361 PF11841.8 EXF84226.1 - 0.038 13.9 2.3 7.9 6.4 0.0 3.4 4 0 0 4 4 4 0 Domain of unknown function (DUF3361) DUF3636 PF12331.8 EXF84226.1 - 0.24 11.2 2.3 11 5.8 0.4 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3636) HEAT_2 PF13646.6 EXF84226.1 - 0.79 10.2 11.6 2.1 8.8 0.2 5.3 5 1 0 5 5 5 0 HEAT repeats Cyclin PF08613.11 EXF84227.1 - 1.6e-30 106.6 1.6 1.7e-30 106.5 0.1 1.9 2 1 0 2 2 2 1 Cyclin Cyclin_N PF00134.23 EXF84227.1 - 0.0011 18.7 0.1 0.0019 18.0 0.1 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain CHZ PF09649.10 EXF84229.1 - 1.7e-18 65.8 2.1 1.7e-18 65.8 2.1 2.5 2 1 0 2 2 2 1 Histone chaperone domain CHZ GP24_25 PF17388.2 EXF84229.1 - 0.21 11.6 8.9 0.07 13.1 2.8 2.1 1 1 1 2 2 2 0 Tail assembly gene products 24 & 25 DUF4763 PF15960.5 EXF84229.1 - 1.5 8.0 3.8 1.7 7.9 3.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4763) Use1 PF09753.9 EXF84230.1 - 0.04 13.6 0.0 0.04 13.6 0.0 1.1 1 0 0 1 1 1 0 Membrane fusion protein Use1 Apc15p PF05841.11 EXF84231.1 - 3.9e-27 95.5 11.8 8.6e-27 94.4 11.8 1.6 1 0 0 1 1 1 1 Apc15p protein TFIIA PF03153.13 EXF84231.1 - 0.007 16.4 33.9 0.007 16.4 33.9 2.4 1 1 1 2 2 2 1 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 EXF84231.1 - 0.0093 15.6 9.1 0.0093 15.6 9.1 1.5 2 0 0 2 2 2 1 Spt20 family DUF2722 PF10846.8 EXF84231.1 - 0.045 12.7 20.0 0.008 15.2 6.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) YkyB PF14177.6 EXF84231.1 - 0.15 12.4 2.3 0.25 11.6 2.3 1.2 1 0 0 1 1 1 0 YkyB-like protein RNA_pol_Rpc4 PF05132.14 EXF84231.1 - 0.15 12.5 0.2 0.15 12.5 0.2 2.7 3 0 0 3 3 3 0 RNA polymerase III RPC4 Med3 PF11593.8 EXF84231.1 - 0.42 9.7 11.3 0.69 9.0 11.3 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Androgen_recep PF02166.16 EXF84231.1 - 1.2 7.9 12.1 2.3 7.0 12.1 1.4 1 0 0 1 1 1 0 Androgen receptor GATase_2 PF00310.21 EXF84232.1 - 1.4e-182 607.1 0.0 1.9e-182 606.7 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferases class-II Glu_synthase PF01645.17 EXF84232.1 - 3.6e-155 516.6 0.0 5.6e-155 516.0 0.0 1.3 1 0 0 1 1 1 1 Conserved region in glutamate synthase Glu_syn_central PF04898.14 EXF84232.1 - 4.7e-111 370.7 0.0 2.9e-109 364.9 0.0 2.3 2 0 0 2 2 2 1 Glutamate synthase central domain GXGXG PF01493.19 EXF84232.1 - 9.9e-88 292.7 2.7 1.7e-87 291.9 2.7 1.4 1 0 0 1 1 1 1 GXGXG motif Pyr_redox_2 PF07992.14 EXF84232.1 - 9e-23 80.9 0.1 5.1e-22 78.5 0.1 2.1 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Fer4_20 PF14691.6 EXF84232.1 - 3.2e-21 75.2 0.1 7.1e-21 74.1 0.1 1.6 1 0 0 1 1 1 1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster NAD_binding_8 PF13450.6 EXF84232.1 - 1.3e-08 34.9 0.0 4.5e-08 33.2 0.0 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EXF84232.1 - 1.3e-07 31.6 0.5 0.00062 19.4 0.2 2.6 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox PF00070.27 EXF84232.1 - 1.2e-06 29.0 0.1 0.00058 20.4 0.0 3.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 EXF84232.1 - 1.8e-06 27.5 0.1 3.5e-06 26.6 0.1 1.5 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase Pyr_redox_3 PF13738.6 EXF84232.1 - 4.5e-06 26.1 1.2 0.08 12.2 0.1 3.8 3 1 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EXF84232.1 - 7.5e-05 22.0 0.0 0.00088 18.5 0.0 2.4 2 0 0 2 2 2 1 FAD binding domain HI0933_like PF03486.14 EXF84232.1 - 8.4e-05 21.4 0.1 8.4e-05 21.4 0.1 1.7 2 0 0 2 2 2 1 HI0933-like protein FAD_oxidored PF12831.7 EXF84232.1 - 0.00017 21.1 0.1 0.00017 21.1 0.1 1.9 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 EXF84232.1 - 0.00042 19.7 0.0 0.00095 18.5 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain AlaDh_PNT_C PF01262.21 EXF84232.1 - 0.0011 18.3 0.3 0.087 12.1 0.0 2.4 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_7 PF13241.6 EXF84232.1 - 0.0022 18.4 0.5 1.1 9.8 0.1 3.0 3 0 0 3 3 2 1 Putative NAD(P)-binding Thi4 PF01946.17 EXF84232.1 - 0.0086 15.3 1.0 0.023 13.9 0.0 2.1 2 0 0 2 2 2 1 Thi4 family NAD_Gly3P_dh_N PF01210.23 EXF84232.1 - 0.01 15.8 0.0 0.024 14.6 0.0 1.6 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Lycopene_cycl PF05834.12 EXF84232.1 - 0.014 14.5 0.3 0.52 9.3 0.1 2.8 4 0 0 4 4 4 0 Lycopene cyclase protein GIDA PF01134.22 EXF84232.1 - 0.019 14.1 0.5 0.14 11.3 0.0 2.3 2 0 0 2 2 2 0 Glucose inhibited division protein A 2-Hacid_dh_C PF02826.19 EXF84232.1 - 0.033 13.5 0.0 0.36 10.2 0.0 2.5 3 0 0 3 3 3 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain FMO-like PF00743.19 EXF84232.1 - 0.041 12.3 0.0 3.7 5.9 0.0 2.8 2 1 1 3 3 3 0 Flavin-binding monooxygenase-like FMN_dh PF01070.18 EXF84232.1 - 0.041 12.9 0.8 0.13 11.2 0.8 1.8 2 0 0 2 2 2 0 FMN-dependent dehydrogenase AdoHcyase_NAD PF00670.21 EXF84232.1 - 0.071 13.2 0.3 5.1 7.1 0.1 2.8 2 0 0 2 2 2 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain DUF1048 PF06304.11 EXF84232.1 - 0.082 13.4 0.8 0.26 11.8 0.3 2.1 2 0 0 2 2 1 0 Protein of unknown function (DUF1048) F420_oxidored PF03807.17 EXF84232.1 - 0.15 12.7 0.0 2.8 8.6 0.0 2.8 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent Rossmann-like PF10727.9 EXF84232.1 - 0.52 10.2 1.7 3 7.7 0.0 2.6 2 0 0 2 2 2 0 Rossmann-like domain 6PF2K PF01591.18 EXF84233.1 - 3e-64 216.4 0.0 5.3e-46 156.7 0.0 2.2 2 0 0 2 2 2 2 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 EXF84233.1 - 2e-31 109.2 0.2 3.6e-25 88.8 0.0 2.5 3 0 0 3 3 3 2 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 EXF84233.1 - 0.0036 17.5 0.0 0.02 15.1 0.0 2.1 1 1 0 1 1 1 1 AAA domain CARD PF00619.21 EXF84233.1 - 0.021 14.8 0.4 0.094 12.8 0.4 1.9 1 1 0 1 1 1 0 Caspase recruitment domain KTI12 PF08433.10 EXF84233.1 - 0.031 13.7 0.0 0.056 12.9 0.0 1.3 1 0 0 1 1 1 0 Chromatin associated protein KTI12 Sigma70_r4_2 PF08281.12 EXF84233.1 - 0.034 13.8 0.1 2.1 8.1 0.0 2.5 2 0 0 2 2 2 0 Sigma-70, region 4 dCMP_cyt_deam_1 PF00383.23 EXF84234.1 - 2.9e-09 36.7 0.0 5.7e-09 35.8 0.0 1.5 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EXF84234.1 - 0.0014 18.4 0.1 0.0029 17.4 0.1 1.4 1 0 0 1 1 1 1 MafB19-like deaminase RNase_H PF00075.24 EXF84235.1 - 6.7e-34 117.1 0.3 1.5e-33 115.9 0.3 1.6 1 0 0 1 1 1 1 RNase H Cauli_VI PF01693.16 EXF84235.1 - 1.4e-31 108.5 3.9 2.7e-18 66.0 0.5 2.5 2 0 0 2 2 2 2 Caulimovirus viroplasmin Na_H_Exchanger PF00999.21 EXF84236.1 - 2.4e-46 158.2 18.1 3.2e-46 157.8 18.1 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family TIG PF01833.24 EXF84238.1 - 4.8e-10 39.4 1.2 1.7e-09 37.6 0.4 2.2 2 0 0 2 2 2 1 IPT/TIG domain Ank PF00023.30 EXF84238.1 - 5.3e-08 33.0 0.1 5.5e-05 23.4 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeat Ank_2 PF12796.7 EXF84238.1 - 3e-07 30.9 0.0 6.5e-07 29.8 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EXF84238.1 - 1e-06 28.9 0.1 2.8e-06 27.5 0.0 1.9 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 EXF84238.1 - 2.5e-06 27.9 0.1 9.4e-06 26.1 0.0 2.1 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EXF84238.1 - 3.9e-05 23.7 0.1 0.007 16.8 0.0 2.8 2 0 0 2 2 2 1 Ankyrin repeat DUF4199 PF13858.6 EXF84239.1 - 0.8 10.1 5.3 0.57 10.6 0.9 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF4199) adh_short_C2 PF13561.6 EXF84240.1 - 6.1e-21 75.0 3.9 1.8e-13 50.6 0.5 2.3 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF84240.1 - 9.4e-18 64.4 4.6 7e-11 41.9 0.5 2.8 3 0 0 3 3 3 2 short chain dehydrogenase KR PF08659.10 EXF84240.1 - 3.3e-06 27.1 1.9 4.6e-06 26.7 1.3 1.6 2 0 0 2 2 2 1 KR domain Sacchrp_dh_NADP PF03435.18 EXF84240.1 - 4.3e-06 27.0 1.7 5.3e-06 26.7 0.6 1.7 2 1 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain DAO PF01266.24 EXF84240.1 - 0.0018 17.9 8.3 0.093 12.3 3.4 2.5 1 1 1 2 2 2 2 FAD dependent oxidoreductase 3Beta_HSD PF01073.19 EXF84240.1 - 0.014 14.4 0.1 0.021 13.8 0.1 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family ApbA PF02558.16 EXF84240.1 - 0.028 14.0 0.3 0.051 13.2 0.3 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA F420_oxidored PF03807.17 EXF84240.1 - 0.03 14.9 1.8 0.095 13.3 0.7 2.3 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent Pyr_redox PF00070.27 EXF84240.1 - 0.047 14.3 0.1 0.15 12.7 0.1 1.9 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DUF1786 PF08735.10 EXF84240.1 - 0.06 12.6 0.4 0.15 11.3 0.2 1.7 1 1 1 2 2 2 0 Putative pyruvate format-lyase activating enzyme (DUF1786) Methyltransf_25 PF13649.6 EXF84240.1 - 0.14 12.9 0.1 2.1 9.1 0.0 2.6 2 1 1 3 3 3 0 Methyltransferase domain Nic96 PF04097.14 EXF84241.1 - 1.2e-229 763.9 0.0 1.6e-229 763.5 0.0 1.1 1 0 0 1 1 1 1 Nup93/Nic96 Nucleoporin_FG PF13634.6 EXF84241.1 - 0.00029 21.6 83.7 18 6.2 1.3 4.5 2 1 1 3 3 3 2 Nucleoporin FG repeat region TFIIA PF03153.13 EXF84241.1 - 5.1 7.0 13.0 9.4 6.1 13.0 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit JmjC PF02373.22 EXF84242.1 - 3.2e-10 40.4 0.1 1e-09 38.8 0.1 1.9 1 1 0 1 1 1 1 JmjC domain, hydroxylase zf-4CXXC_R1 PF10497.9 EXF84242.1 - 1e-09 38.5 13.1 1e-09 38.5 13.1 2.5 2 0 0 2 2 2 1 Zinc-finger domain of monoamine-oxidase A repressor R1 Cupin_2 PF07883.11 EXF84242.1 - 0.0035 17.0 0.0 0.0076 15.9 0.0 1.5 1 0 0 1 1 1 1 Cupin domain UbiA PF01040.18 EXF84243.1 - 1.7e-40 138.9 20.1 2.3e-40 138.5 20.1 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family Ribosom_S12_S23 PF00164.25 EXF84244.1 - 3.5e-51 171.6 0.6 4.3e-51 171.3 0.6 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 DUF5315 PF17242.2 EXF84245.1 - 1.9e-29 101.3 2.0 3.7e-29 100.4 2.0 1.5 1 0 0 1 1 1 1 Disordered region of unknown function (DUF5315) Inhibitor_I9 PF05922.16 EXF84246.1 - 0.0024 18.5 0.0 0.0029 18.3 0.0 1.2 1 0 0 1 1 1 1 Peptidase inhibitor I9 HOOK PF05622.12 EXF84247.1 - 1.7e-06 26.6 84.2 0.87 7.7 0.0 4.1 2 1 0 2 2 2 2 HOOK protein Fez1 PF06818.15 EXF84247.1 - 0.026 15.0 63.0 0.023 15.2 21.0 4.2 2 1 1 3 3 3 0 Fez1 ADK PF00406.22 EXF84248.1 - 7.8e-49 165.6 0.3 1.7e-48 164.5 0.3 1.6 1 1 0 1 1 1 1 Adenylate kinase ADK_lid PF05191.14 EXF84248.1 - 6.7e-17 61.2 0.0 2.2e-16 59.5 0.0 1.9 2 0 0 2 2 2 1 Adenylate kinase, active site lid AAA_17 PF13207.6 EXF84248.1 - 8.3e-13 48.9 1.2 2e-12 47.7 0.3 2.2 2 1 0 2 2 2 1 AAA domain Trimer_CC PF08954.11 EXF84248.1 - 0.12 11.9 0.0 0.27 10.8 0.0 1.6 1 0 0 1 1 1 0 Trimerisation motif BLOC1_2 PF10046.9 EXF84248.1 - 0.15 12.4 0.3 0.33 11.3 0.3 1.6 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 MitMem_reg PF13012.6 EXF84249.1 - 1.7e-37 128.3 0.1 5.8e-37 126.5 0.1 1.8 2 0 0 2 2 2 1 Maintenance of mitochondrial structure and function JAB PF01398.21 EXF84249.1 - 1.4e-30 105.7 0.0 3.2e-30 104.5 0.0 1.6 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease tRNA_bind_2 PF13725.6 EXF84249.1 - 0.017 14.9 6.1 0.025 14.3 6.1 1.2 1 0 0 1 1 1 0 Possible tRNA binding domain Connexin PF00029.19 EXF84249.1 - 0.6 9.8 2.9 0.87 9.3 2.9 1.2 1 0 0 1 1 1 0 Connexin SWIM PF04434.17 EXF84250.1 - 0.00025 20.6 0.9 0.19 11.4 0.1 2.5 2 0 0 2 2 2 2 SWIM zinc finger Coprogen_oxidas PF01218.18 EXF84251.1 - 4.5e-145 481.9 0.1 5.4e-145 481.7 0.1 1.1 1 0 0 1 1 1 1 Coproporphyrinogen III oxidase DUF1651 PF07864.11 EXF84251.1 - 0.0094 16.3 0.0 0.15 12.4 0.0 2.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1651) Atg8 PF02991.16 EXF84252.1 - 2.9e-51 172.0 0.2 3.4e-51 171.8 0.2 1.0 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.13 EXF84252.1 - 3.3e-06 27.4 0.0 3.9e-06 27.2 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 ABC_membrane PF00664.23 EXF84253.1 - 1.1e-88 297.4 26.2 2.8e-48 164.9 3.5 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EXF84253.1 - 9.9e-65 217.2 0.0 9.7e-33 113.6 0.0 2.8 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EXF84253.1 - 2e-16 60.1 0.4 5.3e-05 22.8 0.0 4.3 2 2 2 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 EXF84253.1 - 7.3e-07 29.7 2.3 0.0051 17.2 0.3 3.2 2 2 0 2 2 2 2 AAA ATPase domain AAA_30 PF13604.6 EXF84253.1 - 1.5e-06 28.1 5.1 0.013 15.3 0.0 4.4 5 0 0 5 5 4 2 AAA domain AAA_29 PF13555.6 EXF84253.1 - 2.2e-06 27.3 1.9 0.024 14.4 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain ABC_ATPase PF09818.9 EXF84253.1 - 6.1e-06 25.3 0.5 0.0073 15.2 0.0 2.6 2 0 0 2 2 2 2 Predicted ATPase of the ABC class RsgA_GTPase PF03193.16 EXF84253.1 - 6.3e-05 22.9 0.0 0.19 11.6 0.0 2.7 2 0 0 2 2 2 2 RsgA GTPase Zeta_toxin PF06414.12 EXF84253.1 - 8.8e-05 21.9 0.1 0.062 12.6 0.0 2.4 2 0 0 2 2 2 2 Zeta toxin APS_kinase PF01583.20 EXF84253.1 - 0.00017 21.5 0.2 0.054 13.4 0.1 2.4 2 0 0 2 2 2 1 Adenylylsulphate kinase AAA_22 PF13401.6 EXF84253.1 - 0.00018 21.8 5.6 0.46 10.8 0.1 4.7 3 2 0 3 3 3 2 AAA domain AAA PF00004.29 EXF84253.1 - 0.00041 20.8 0.3 1.5 9.2 0.0 4.3 3 1 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 EXF84253.1 - 0.0032 17.6 0.2 1.7 8.8 0.0 2.6 2 0 0 2 2 2 1 AAA domain SbcCD_C PF13558.6 EXF84253.1 - 0.0037 17.5 0.7 5.4 7.3 0.3 3.4 2 1 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_25 PF13481.6 EXF84253.1 - 0.0057 16.2 0.5 11 5.6 0.0 3.8 4 0 0 4 4 4 0 AAA domain DUF3987 PF13148.6 EXF84253.1 - 0.0089 15.1 7.3 0.49 9.3 0.0 3.3 3 0 0 3 3 3 2 Protein of unknown function (DUF3987) AAA_18 PF13238.6 EXF84253.1 - 0.012 16.2 0.8 5.8 7.5 0.0 2.8 2 1 0 2 2 2 0 AAA domain AAA_21 PF13304.6 EXF84253.1 - 0.019 14.8 4.7 0.35 10.6 0.0 3.6 3 1 1 4 4 4 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_24 PF13479.6 EXF84253.1 - 0.034 13.9 0.1 13 5.4 0.0 2.8 2 1 0 2 2 2 0 AAA domain AAA_23 PF13476.6 EXF84253.1 - 0.045 14.3 6.8 4.5 7.7 0.4 3.3 3 0 0 3 3 3 0 AAA domain PRK PF00485.18 EXF84253.1 - 0.045 13.5 0.2 1.7 8.4 0.0 2.6 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family AAA_5 PF07728.14 EXF84253.1 - 0.051 13.6 0.0 11 6.0 0.0 3.5 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) SRP54 PF00448.22 EXF84253.1 - 0.056 13.1 0.4 9.2 5.8 0.1 2.8 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain DUF87 PF01935.17 EXF84253.1 - 0.066 13.3 3.8 1.1 9.3 0.2 3.0 3 0 0 3 3 3 0 Helicase HerA, central domain AAA_15 PF13175.6 EXF84253.1 - 0.072 12.8 0.3 5.3 6.6 0.0 2.8 3 0 0 3 3 3 0 AAA ATPase domain NB-ARC PF00931.22 EXF84253.1 - 0.12 11.5 0.6 12 5.0 0.0 2.5 2 0 0 2 2 2 0 NB-ARC domain Rad17 PF03215.15 EXF84253.1 - 0.12 12.2 0.0 0.34 10.8 0.0 1.7 1 0 0 1 1 1 0 Rad17 P-loop domain MMR_HSR1 PF01926.23 EXF84253.1 - 0.18 11.9 0.3 29 4.8 0.0 3.1 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_17 PF13207.6 EXF84253.1 - 0.46 10.9 3.4 12 6.3 0.1 3.3 4 0 0 4 4 2 0 AAA domain Pyr_redox_2 PF07992.14 EXF84254.1 - 3.6e-22 78.9 0.0 5.4e-22 78.4 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EXF84254.1 - 1.2e-12 48.1 0.2 3.8e-12 46.6 0.1 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EXF84254.1 - 0.0015 17.8 0.0 0.0029 16.8 0.0 1.4 1 0 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) Lycopene_cycl PF05834.12 EXF84254.1 - 0.0072 15.4 0.0 0.012 14.7 0.0 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_3 PF13738.6 EXF84254.1 - 0.01 15.1 0.0 0.015 14.5 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EXF84254.1 - 0.063 12.1 0.1 6.5 5.5 0.2 2.1 2 0 0 2 2 2 0 Tryptophan halogenase HI0933_like PF03486.14 EXF84254.1 - 0.14 10.8 0.1 1.2 7.8 0.1 2.0 2 0 0 2 2 2 0 HI0933-like protein DAO PF01266.24 EXF84254.1 - 0.18 11.4 1.0 0.53 9.8 0.2 2.2 3 0 0 3 3 3 0 FAD dependent oxidoreductase DUF1180 PF06679.12 EXF84254.1 - 5.9 7.3 7.2 11 6.3 7.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) PI-PLC-X PF00388.19 EXF84255.1 - 8.1e-59 197.4 0.0 1.6e-58 196.5 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 EXF84255.1 - 1e-41 141.9 0.1 2.8e-41 140.5 0.1 1.8 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain C2 PF00168.30 EXF84255.1 - 2.6e-09 37.3 0.1 1.7e-08 34.6 0.0 2.3 2 1 0 2 2 2 1 C2 domain PH_12 PF16457.5 EXF84255.1 - 0.0016 19.0 1.7 0.02 15.4 0.8 3.0 2 1 0 2 2 2 1 Pleckstrin homology domain EF-hand_like PF09279.11 EXF84255.1 - 0.0065 16.9 0.0 0.017 15.6 0.0 1.7 1 0 0 1 1 1 1 Phosphoinositide-specific phospholipase C, efhand-like PH PF00169.29 EXF84255.1 - 0.021 15.3 2.8 0.066 13.7 1.1 2.5 2 0 0 2 2 2 0 PH domain PH_11 PF15413.6 EXF84255.1 - 1.8 9.0 6.0 4.1 7.9 3.9 2.6 2 1 0 2 2 2 0 Pleckstrin homology domain DHDPS PF00701.22 EXF84256.1 - 1.7e-44 151.7 0.0 2e-44 151.4 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family Pkinase PF00069.25 EXF84257.1 - 1.9e-42 145.5 0.0 6.5e-41 140.4 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF84257.1 - 5.8e-28 97.9 0.0 8.7e-28 97.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EXF84257.1 - 0.0044 15.9 0.0 0.0066 15.3 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EXF84257.1 - 0.046 13.6 0.1 0.087 12.7 0.1 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 EXF84257.1 - 0.089 12.1 0.0 0.16 11.3 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Clr5 PF14420.6 EXF84258.1 - 2e-19 69.6 3.5 4.2e-19 68.5 3.5 1.6 1 0 0 1 1 1 1 Clr5 domain TPR_12 PF13424.6 EXF84258.1 - 3e-05 24.2 0.9 3e-05 24.2 0.9 3.2 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.28 EXF84258.1 - 0.028 14.3 0.0 12 5.9 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 EXF84258.1 - 0.039 14.1 0.1 14 6.1 0.0 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat FAD_binding_6 PF00970.24 EXF84258.1 - 0.082 13.3 0.0 0.16 12.3 0.0 1.4 1 0 0 1 1 1 0 Oxidoreductase FAD-binding domain TPR_19 PF14559.6 EXF84258.1 - 0.18 12.3 3.9 0.43 11.1 1.0 3.0 2 1 2 4 4 4 0 Tetratricopeptide repeat TPR_7 PF13176.6 EXF84258.1 - 0.2 11.8 4.8 12 6.2 0.1 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat SAP PF02037.27 EXF84260.1 - 1.6e-11 43.6 0.3 2.7e-11 42.9 0.3 1.4 1 0 0 1 1 1 1 SAP domain Tho1_MOS11_C PF18592.1 EXF84260.1 - 9.2e-07 28.6 1.6 9.2e-07 28.6 1.6 2.3 2 0 0 2 2 2 1 Tho1/MOS11 C-terminal domain HeH PF12949.7 EXF84260.1 - 0.094 12.5 0.3 0.23 11.2 0.3 1.7 1 0 0 1 1 1 0 HeH/LEM domain DUF3275 PF11679.8 EXF84260.1 - 0.24 11.3 10.9 0.43 10.5 10.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3275) Mitofilin PF09731.9 EXF84260.1 - 0.53 9.1 19.4 0.66 8.8 19.4 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Metallophos PF00149.28 EXF84261.1 - 1.4e-16 61.6 0.5 2.4e-16 60.8 0.1 1.6 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase GST_N PF02798.20 EXF84263.1 - 1.5e-15 57.3 0.0 2.8e-15 56.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EXF84263.1 - 2.6e-13 50.2 0.0 5.2e-13 49.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EXF84263.1 - 4.1e-12 46.2 0.0 9.3e-12 45.1 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EXF84263.1 - 7e-08 32.6 0.0 1.4e-07 31.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EXF84263.1 - 2.2e-07 31.0 0.0 9e-07 29.0 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EXF84263.1 - 1.2e-06 28.5 0.3 7.4e-06 25.9 0.1 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain SF1-HH PF16275.5 EXF84264.1 - 7.9e-43 145.4 6.9 1.2e-42 144.9 0.6 2.5 1 1 1 2 2 2 1 Splicing factor 1 helix-hairpin domain zf-CCHC PF00098.23 EXF84264.1 - 6.8e-12 44.9 11.1 1.4e-05 25.0 0.8 2.4 2 0 0 2 2 2 2 Zinc knuckle KH_1 PF00013.29 EXF84264.1 - 6.6e-08 32.3 0.2 1.2e-07 31.4 0.2 1.4 1 0 0 1 1 1 1 KH domain zf-CCHC_3 PF13917.6 EXF84264.1 - 1e-06 28.6 6.4 0.00046 20.1 3.1 2.6 1 1 1 2 2 2 2 Zinc knuckle zf-CCHC_6 PF15288.6 EXF84264.1 - 0.00034 20.4 7.2 0.11 12.3 0.3 2.8 1 1 1 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.6 EXF84264.1 - 0.0011 18.6 4.9 0.45 10.3 0.4 2.5 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_2 PF13696.6 EXF84264.1 - 0.015 15.1 0.5 0.015 15.1 0.5 2.5 2 0 0 2 2 2 0 Zinc knuckle PHD_4 PF16866.5 EXF84264.1 - 0.35 11.0 2.1 0.76 9.9 2.1 1.5 1 0 0 1 1 1 0 PHD-finger Peptidase_M28 PF04389.17 EXF84265.1 - 2.7e-37 128.4 0.0 4.8e-37 127.6 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 EXF84265.1 - 0.0099 15.6 0.0 0.018 14.8 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Med11 PF10280.9 EXF84266.1 - 4.7e-49 166.4 0.1 5.8e-49 166.1 0.1 1.1 1 0 0 1 1 1 1 Mediator complex protein Mst1_SARAH PF11629.8 EXF84266.1 - 0.023 14.8 1.2 0.99 9.5 0.1 2.7 3 0 0 3 3 3 0 C terminal SARAH domain of Mst1 GPS2_interact PF15784.5 EXF84266.1 - 0.06 13.8 0.2 0.14 12.6 0.2 1.7 1 0 0 1 1 1 0 G-protein pathway suppressor 2-interacting domain TMV_coat PF00721.21 EXF84266.1 - 0.11 12.3 0.0 0.17 11.7 0.0 1.2 1 0 0 1 1 1 0 Virus coat protein (TMV like) Med21 PF11221.8 EXF84266.1 - 0.25 11.6 3.3 0.49 10.6 3.3 1.7 1 1 0 1 1 1 0 Subunit 21 of Mediator complex WD40 PF00400.32 EXF84267.1 - 2.6e-40 135.7 24.3 9.5e-08 32.6 0.3 7.0 6 1 0 6 6 6 6 WD domain, G-beta repeat TFIID_NTD2 PF04494.15 EXF84267.1 - 3.5e-39 134.0 1.3 5.1e-39 133.5 1.3 1.2 1 0 0 1 1 1 1 WD40 associated region in TFIID subunit, NTD2 domain ANAPC4_WD40 PF12894.7 EXF84267.1 - 3.1e-10 40.2 1.2 0.03 14.6 0.1 5.1 2 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain LisH PF08513.11 EXF84267.1 - 3.1e-06 26.9 0.0 6.2e-06 26.0 0.0 1.5 1 0 0 1 1 1 1 LisH eIF2A PF08662.11 EXF84267.1 - 8e-05 22.6 0.2 0.017 15.0 0.0 3.3 3 1 1 4 4 4 2 Eukaryotic translation initiation factor eIF2A Nucleoporin_N PF08801.11 EXF84267.1 - 0.00021 20.2 0.1 1.5 7.5 0.0 3.8 2 2 1 4 4 4 1 Nup133 N terminal like Nup160 PF11715.8 EXF84267.1 - 0.00037 19.3 0.9 1.3 7.5 0.1 3.2 2 1 0 3 3 3 2 Nucleoporin Nup120/160 RAB3GAP2_N PF14655.6 EXF84267.1 - 0.0046 16.3 0.2 1.9 7.7 0.0 3.1 3 1 1 4 4 4 1 Rab3 GTPase-activating protein regulatory subunit N-terminus AsnC_trans_reg PF01037.21 EXF84267.1 - 0.059 13.3 0.1 0.39 10.7 0.0 2.3 2 0 0 2 2 2 0 Lrp/AsnC ligand binding domain Nbas_N PF15492.6 EXF84267.1 - 0.067 12.5 0.2 5.2 6.3 0.0 2.4 1 1 1 2 2 2 0 Neuroblastoma-amplified sequence, N terminal Vps5 PF09325.10 EXF84268.1 - 4.1e-88 294.9 6.3 5.7e-88 294.4 6.3 1.2 1 0 0 1 1 1 1 Vps5 C terminal like PX PF00787.24 EXF84268.1 - 3.3e-24 85.1 0.1 6.9e-24 84.0 0.0 1.6 2 0 0 2 2 2 1 PX domain BAR_2 PF10455.9 EXF84268.1 - 0.00055 19.2 2.3 0.001 18.3 2.3 1.5 1 0 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking BAR_3 PF16746.5 EXF84268.1 - 0.0017 18.1 7.1 0.015 15.0 3.3 2.3 1 1 1 2 2 2 1 BAR domain of APPL family BAR_3_WASP_bdg PF10456.9 EXF84268.1 - 0.0042 16.6 0.8 0.04 13.4 0.8 2.1 1 1 0 1 1 1 1 WASP-binding domain of Sorting nexin protein DUF713 PF05218.14 EXF84268.1 - 0.18 11.6 6.0 0.14 11.9 1.3 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF713) DUF3450 PF11932.8 EXF84268.1 - 1.8 7.8 9.0 0.2 10.9 4.6 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) BAR PF03114.18 EXF84268.1 - 2.2 7.8 9.6 5.6 6.5 9.6 1.7 1 1 0 1 1 1 0 BAR domain Ribosomal_L31 PF01197.18 EXF84269.1 - 5.1e-05 23.4 0.2 0.00088 19.5 0.0 2.3 2 0 0 2 2 2 1 Ribosomal protein L31 HSP90 PF00183.18 EXF84271.1 - 2.8e-222 739.2 29.9 3.6e-222 738.9 29.9 1.1 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.26 EXF84271.1 - 6.1e-15 55.7 0.1 1.1e-14 54.8 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 EXF84271.1 - 1.5e-09 37.8 0.1 4.7e-09 36.2 0.1 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase LOH1CR12 PF10158.9 EXF84271.1 - 0.034 14.2 0.3 0.13 12.3 0.3 2.0 1 0 0 1 1 1 0 Tumour suppressor protein Cofac_haem_bdg PF04187.13 EXF84271.1 - 0.14 12.1 0.4 0.56 10.2 0.1 2.1 2 0 0 2 2 2 0 Haem-binding uptake, Tiki superfamily, ChaN Bac_rhamnosid6H PF17389.2 EXF84273.1 - 2.4e-10 40.2 0.1 4.5e-10 39.3 0.1 1.3 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain Trehalase PF01204.18 EXF84273.1 - 0.0043 15.9 0.2 0.0064 15.4 0.2 1.2 1 0 0 1 1 1 1 Trehalase Methyltransf_11 PF08241.12 EXF84274.1 - 0.002 18.8 0.0 0.0048 17.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF84274.1 - 0.01 16.5 0.0 0.024 15.3 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain F-box PF00646.33 EXF84276.1 - 8.4e-07 28.7 0.3 1.9e-06 27.6 0.3 1.7 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EXF84276.1 - 5.7e-06 26.1 0.0 1.4e-05 24.9 0.0 1.7 1 0 0 1 1 1 1 F-box-like Tom37 PF10568.9 EXF84277.1 - 6.7e-34 116.9 0.2 9.8e-34 116.4 0.2 1.3 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein GST_N_4 PF17172.4 EXF84277.1 - 3.3e-07 31.0 0.0 6.1e-07 30.1 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain GST_C_6 PF17171.4 EXF84277.1 - 7.7e-07 28.8 1.4 4e-06 26.5 0.0 2.9 3 1 0 3 3 3 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EXF84277.1 - 0.0078 16.2 0.0 0.027 14.5 0.0 1.9 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain PIG-U PF06728.13 EXF84278.1 - 1.5e-124 416.0 25.4 1.7e-124 415.8 25.4 1.0 1 0 0 1 1 1 1 GPI transamidase subunit PIG-U 8TM_micro PF17028.5 EXF84278.1 - 0.13 12.0 7.7 0.57 9.9 7.5 2.1 1 1 0 1 1 1 0 8TM Microsporidial transmembrane domain Pescadillo_N PF06732.11 EXF84279.1 - 5.3e-122 406.6 0.0 5.3e-122 406.6 0.0 1.6 2 0 0 2 2 2 1 Pescadillo N-terminus Astro_capsid_p PF12226.8 EXF84279.1 - 0.0026 17.0 9.2 0.0026 17.0 9.2 2.3 2 0 0 2 2 2 1 Turkey astrovirus capsid protein BRCT_2 PF16589.5 EXF84279.1 - 0.0028 18.0 0.3 0.021 15.2 0.0 2.6 2 1 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain RRN9 PF10680.9 EXF84280.1 - 7.3e-17 61.4 0.1 7.3e-17 61.4 0.1 3.2 3 0 0 3 3 3 1 RNA polymerase I specific transcription initiation factor FAD-oxidase_C PF02913.19 EXF84281.1 - 2.2e-63 214.2 0.4 2.2e-63 214.2 0.4 1.8 2 0 0 2 2 2 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 EXF84281.1 - 2.2e-37 127.9 0.0 4.9e-37 126.8 0.0 1.6 1 0 0 1 1 1 1 FAD binding domain Clr5 PF14420.6 EXF84282.1 - 1.3e-18 67.0 0.6 8.5e-18 64.3 0.4 2.5 2 0 0 2 2 2 1 Clr5 domain ECH_1 PF00378.20 EXF84283.1 - 5.9e-42 143.7 0.0 7.5e-42 143.4 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EXF84283.1 - 1.1e-23 84.3 0.0 1.5e-23 83.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase LppA PF16708.5 EXF84283.1 - 0.01 15.8 0.0 0.019 14.9 0.0 1.3 1 0 0 1 1 1 0 Lipoprotein confined to pathogenic Mycobacterium SPRY PF00622.28 EXF84284.1 - 1.1e-06 28.7 0.2 3e-06 27.3 0.0 1.8 3 0 0 3 3 3 1 SPRY domain Na_Ca_ex PF01699.24 EXF84285.1 - 3.9e-41 140.5 38.5 1.5e-21 77.0 18.7 2.2 2 0 0 2 2 2 2 Sodium/calcium exchanger protein Pkinase PF00069.25 EXF84286.1 - 9.7e-65 218.5 0.0 1.9e-64 217.6 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF84286.1 - 5.9e-37 127.4 0.0 4.9e-31 108.0 0.0 2.5 3 0 0 3 3 3 2 Protein tyrosine kinase Kinase-like PF14531.6 EXF84286.1 - 3.6e-07 29.8 0.0 3.2e-05 23.4 0.0 2.2 1 1 0 1 1 1 1 Kinase-like APH PF01636.23 EXF84286.1 - 0.00024 21.1 0.0 0.00052 20.0 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EXF84286.1 - 0.016 14.2 0.2 0.027 13.4 0.2 1.3 1 0 0 1 1 1 0 Haspin like kinase domain RIO1 PF01163.22 EXF84286.1 - 0.02 14.5 0.0 0.041 13.5 0.0 1.4 1 0 0 1 1 1 0 RIO1 family Kdo PF06293.14 EXF84286.1 - 0.03 13.7 0.0 0.055 12.8 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EXF84286.1 - 0.76 8.5 3.8 0.24 10.1 0.1 2.0 2 0 0 2 2 2 0 Fungal protein kinase GWT1 PF06423.12 EXF84287.1 - 4.2e-44 150.3 2.8 4.2e-44 150.3 2.8 1.9 2 0 0 2 2 2 1 GWT1 DUF4818 PF16089.5 EXF84287.1 - 0.00021 21.7 1.0 0.0011 19.4 0.0 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4818) Pkinase PF00069.25 EXF84290.1 - 2.2e-55 187.9 0.0 3.3e-55 187.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF84290.1 - 1.7e-32 112.7 0.0 5.3e-31 107.9 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EXF84290.1 - 0.0041 16.1 0.0 0.006 15.6 0.0 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Pox_ser-thr_kin PF05445.11 EXF84290.1 - 0.028 13.4 0.0 0.04 12.9 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Kdo PF06293.14 EXF84290.1 - 0.14 11.5 0.9 0.3 10.4 0.9 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family HSP70 PF00012.20 EXF84291.1 - 7.2e-11 41.0 0.1 4.6e-10 38.3 0.0 1.9 2 0 0 2 2 2 1 Hsp70 protein FtsA PF14450.6 EXF84291.1 - 0.0011 19.4 0.1 0.011 16.1 0.0 2.4 2 0 0 2 2 2 1 Cell division protein FtsA AAA_16 PF13191.6 EXF84293.1 - 4.8e-10 40.1 0.1 1.5e-09 38.4 0.1 1.9 1 1 0 1 1 1 1 AAA ATPase domain ATPase_2 PF01637.18 EXF84293.1 - 0.0001 22.3 0.1 0.00015 21.7 0.1 1.2 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea DUF815 PF05673.13 EXF84293.1 - 0.0028 16.9 0.0 0.0061 15.8 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_25 PF13481.6 EXF84293.1 - 0.0037 16.9 0.6 0.079 12.5 0.0 2.7 3 0 0 3 3 3 1 AAA domain AAA_7 PF12775.7 EXF84293.1 - 0.0073 15.8 0.0 0.018 14.6 0.0 1.6 2 0 0 2 2 2 1 P-loop containing dynein motor region DNA_pol3_delta PF06144.13 EXF84293.1 - 0.078 12.8 0.2 0.13 12.0 0.2 1.3 1 0 0 1 1 1 0 DNA polymerase III, delta subunit RsgA_GTPase PF03193.16 EXF84293.1 - 0.092 12.6 0.1 7.2 6.5 0.0 2.3 2 0 0 2 2 2 0 RsgA GTPase AAA_29 PF13555.6 EXF84293.1 - 0.15 11.8 0.0 0.32 10.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Fungal_trans_2 PF11951.8 EXF84294.1 - 1.2e-27 96.8 1.8 8.2e-16 57.8 0.3 2.1 2 0 0 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF84294.1 - 8.9e-09 35.3 12.2 1.7e-08 34.4 12.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain AT_hook PF02178.19 EXF84294.1 - 0.21 11.5 7.5 0.19 11.7 5.4 2.2 2 0 0 2 2 2 0 AT hook motif Peptidase_M20 PF01546.28 EXF84295.1 - 4.2e-32 111.5 0.0 8.2e-32 110.6 0.0 1.5 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EXF84295.1 - 2e-13 50.2 0.0 5.8e-13 48.7 0.0 1.9 2 0 0 2 2 2 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 EXF84295.1 - 0.0014 18.3 0.0 0.0028 17.4 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 ABC2_membrane PF01061.24 EXF84296.1 - 1.2e-50 171.8 32.3 6.8e-28 97.5 10.8 2.9 3 0 0 3 3 3 2 ABC-2 type transporter ABC_tran PF00005.27 EXF84296.1 - 3e-50 170.3 0.0 1.1e-23 84.3 0.0 2.5 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 EXF84296.1 - 1.2e-14 54.9 9.2 0.0027 17.6 0.0 4.2 3 1 1 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 EXF84296.1 - 3.4e-09 36.8 1.0 0.00096 19.1 0.1 2.4 2 0 0 2 2 2 2 RsgA GTPase SMC_N PF02463.19 EXF84296.1 - 3.6e-09 36.4 0.9 0.0002 20.9 0.0 3.7 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EXF84296.1 - 4.5e-08 32.7 1.6 0.0092 15.7 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_23 PF13476.6 EXF84296.1 - 6.6e-08 33.3 2.4 0.00089 19.8 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 EXF84296.1 - 1.6e-07 31.7 0.1 0.086 13.1 0.0 3.5 3 0 0 3 3 3 2 AAA domain AAA_16 PF13191.6 EXF84296.1 - 1.8e-07 31.7 0.1 0.023 15.1 0.0 2.7 2 0 0 2 2 2 2 AAA ATPase domain AAA_28 PF13521.6 EXF84296.1 - 4.5e-06 27.0 0.2 0.0097 16.2 0.0 2.6 2 0 0 2 2 2 2 AAA domain PDR_CDR PF06422.12 EXF84296.1 - 1.9e-05 24.5 0.1 5.6e-05 23.0 0.1 1.8 1 0 0 1 1 1 1 CDR ABC transporter AAA_30 PF13604.6 EXF84296.1 - 3.9e-05 23.5 1.0 0.067 12.9 0.0 2.9 3 0 0 3 3 2 2 AAA domain NACHT PF05729.12 EXF84296.1 - 5.6e-05 23.1 0.1 0.26 11.2 0.1 2.6 2 0 0 2 2 2 2 NACHT domain T2SSE PF00437.20 EXF84296.1 - 5.9e-05 22.3 0.2 0.29 10.1 0.0 2.3 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_18 PF13238.6 EXF84296.1 - 0.00016 22.2 0.0 0.56 10.7 0.0 2.4 2 0 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.23 EXF84296.1 - 0.00018 21.6 1.3 0.12 12.5 0.1 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_15 PF13175.6 EXF84296.1 - 0.00036 20.4 0.9 2.9 7.5 0.1 3.2 3 0 0 3 3 3 2 AAA ATPase domain AAA_19 PF13245.6 EXF84296.1 - 0.00038 20.8 0.1 0.074 13.4 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 EXF84296.1 - 0.00065 19.5 0.3 1 9.0 0.1 2.6 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.6 EXF84296.1 - 0.00089 18.9 0.8 1.4 8.5 0.1 2.9 3 0 0 3 3 3 2 AAA domain cobW PF02492.19 EXF84296.1 - 0.0009 18.9 2.5 0.53 9.8 0.3 2.3 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain PDR_assoc PF08370.11 EXF84296.1 - 0.001 18.8 0.2 0.005 16.5 0.2 2.2 1 0 0 1 1 1 1 Plant PDR ABC transporter associated ATP_bind_1 PF03029.17 EXF84296.1 - 0.0011 18.7 0.1 0.81 9.4 0.0 2.4 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein FtsK_SpoIIIE PF01580.18 EXF84296.1 - 0.0024 17.3 0.7 0.42 9.9 0.0 2.5 2 0 0 2 2 2 1 FtsK/SpoIIIE family Pox_A32 PF04665.12 EXF84296.1 - 0.0042 16.6 0.7 0.15 11.5 0.1 2.3 2 0 0 2 2 2 1 Poxvirus A32 protein AAA_7 PF12775.7 EXF84296.1 - 0.0045 16.5 0.1 1.9 8.0 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region RNA_helicase PF00910.22 EXF84296.1 - 0.0051 17.2 0.1 4.8 7.6 0.0 2.9 3 0 0 3 3 2 0 RNA helicase PduV-EutP PF10662.9 EXF84296.1 - 0.0052 16.5 0.2 1.3 8.7 0.1 2.4 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation ATPase_2 PF01637.18 EXF84296.1 - 0.008 16.1 0.0 1.2 8.9 0.0 2.3 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea Roc PF08477.13 EXF84296.1 - 0.011 16.0 0.1 4 7.7 0.0 2.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_33 PF13671.6 EXF84296.1 - 0.011 15.9 0.0 4.4 7.5 0.0 2.7 2 0 0 2 2 2 0 AAA domain SbcCD_C PF13558.6 EXF84296.1 - 0.012 15.9 1.4 5.3 7.4 0.1 3.7 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit KAP_NTPase PF07693.14 EXF84296.1 - 0.018 14.3 0.0 0.14 11.3 0.0 2.1 2 0 0 2 2 2 0 KAP family P-loop domain MobB PF03205.14 EXF84296.1 - 0.029 14.3 0.2 1.8 8.4 0.1 2.3 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_5 PF07728.14 EXF84296.1 - 0.036 14.1 0.3 12 5.9 0.0 2.7 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) ABC_ATPase PF09818.9 EXF84296.1 - 0.039 12.7 0.4 1.1 7.9 0.2 2.7 3 0 0 3 3 3 0 Predicted ATPase of the ABC class Septin PF00735.18 EXF84296.1 - 0.046 13.0 0.2 1.2 8.3 0.0 2.2 2 0 0 2 2 2 0 Septin SRPRB PF09439.10 EXF84296.1 - 0.051 13.0 0.7 8.2 5.8 0.0 2.4 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit AAA_11 PF13086.6 EXF84296.1 - 0.061 13.1 0.2 4.2 7.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain PRK PF00485.18 EXF84296.1 - 0.073 12.8 0.3 2.9 7.6 0.1 2.4 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family NTPase_1 PF03266.15 EXF84296.1 - 0.09 12.7 0.1 7.2 6.5 0.0 3.3 4 0 0 4 4 4 0 NTPase Zeta_toxin PF06414.12 EXF84296.1 - 0.096 12.0 0.3 5.4 6.3 0.1 2.4 2 0 0 2 2 2 0 Zeta toxin IstB_IS21 PF01695.17 EXF84296.1 - 0.1 12.3 0.3 9 6.0 0.0 3.0 3 0 0 3 3 3 0 IstB-like ATP binding protein ATP-synt_ab PF00006.25 EXF84296.1 - 0.15 11.7 0.0 3.1 7.4 0.0 2.4 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain PhoH PF02562.16 EXF84296.1 - 0.17 11.3 0.1 7.9 5.9 0.0 2.3 2 0 0 2 2 2 0 PhoH-like protein Dynamin_N PF00350.23 EXF84296.1 - 0.18 11.8 1.3 7.9 6.5 0.1 2.5 2 0 0 2 2 2 0 Dynamin family DUF2075 PF09848.9 EXF84296.1 - 0.21 10.8 0.1 12 5.0 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) dNK PF01712.19 EXF84296.1 - 0.43 10.4 1.6 29 4.4 0.1 3.0 3 0 0 3 3 3 0 Deoxynucleoside kinase DUF87 PF01935.17 EXF84296.1 - 0.69 10.0 2.4 1.3 9.1 0.9 2.2 2 0 0 2 2 1 0 Helicase HerA, central domain Glyco_hydro_43 PF04616.14 EXF84297.1 - 1.9e-51 175.1 3.7 2.3e-51 174.8 3.7 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 E1-E2_ATPase PF00122.20 EXF84298.1 - 2e-36 125.2 16.6 5.8e-30 104.1 0.2 3.5 3 0 0 3 3 3 2 E1-E2 ATPase Cation_ATPase_C PF00689.21 EXF84298.1 - 1e-24 87.2 6.9 1e-24 87.2 6.9 2.6 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.6 EXF84298.1 - 1e-19 70.4 0.0 2.2e-19 69.3 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EXF84298.1 - 2.9e-19 70.2 0.0 1.1e-17 65.0 0.0 2.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EXF84298.1 - 5.9e-14 51.5 0.1 5.9e-14 51.5 0.1 2.0 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EXF84298.1 - 0.00038 20.3 0.1 0.0024 17.6 0.2 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Exo_endo_phos PF03372.23 EXF84299.1 - 2.1e-11 43.8 0.1 7.2e-11 42.0 0.1 2.0 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family ADH_zinc_N PF00107.26 EXF84301.1 - 8.4e-26 90.5 0.7 1.1e-25 90.1 0.2 1.4 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EXF84301.1 - 9.7e-19 68.7 0.0 3.4e-18 67.0 0.0 1.9 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EXF84301.1 - 1.8e-09 37.4 0.0 1.6e-08 34.4 0.0 2.2 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain AlaDh_PNT_C PF01262.21 EXF84301.1 - 0.022 14.0 0.8 0.022 14.0 0.8 1.8 1 1 1 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain Glyco_hydro_12 PF01670.16 EXF84302.1 - 1.6e-18 67.5 7.0 2.1e-18 67.1 7.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 12 PhzC-PhzF PF02567.16 EXF84303.1 - 9.7e-42 143.4 0.1 2.6e-41 142.0 0.1 1.6 1 1 0 1 1 1 1 Phenazine biosynthesis-like protein PALP PF00291.25 EXF84304.1 - 6.8e-58 196.4 1.2 1.2e-57 195.5 1.2 1.3 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Peptidase_M20 PF01546.28 EXF84304.1 - 6.9e-24 84.7 0.0 2.4e-23 82.9 0.0 1.9 2 0 0 2 2 2 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EXF84304.1 - 5.9e-17 61.6 0.0 1.3e-16 60.5 0.0 1.6 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 EXF84304.1 - 0.005 16.5 0.0 0.011 15.4 0.0 1.6 1 0 0 1 1 1 1 Peptidase family M28 XPC-binding PF09280.11 EXF84304.1 - 0.087 12.6 0.0 3.7 7.4 0.0 2.6 3 0 0 3 3 3 0 XPC-binding domain RrnaAD PF00398.20 EXF84306.1 - 1.3e-06 27.7 0.0 3.4e-06 26.3 0.0 1.7 1 1 0 1 1 1 1 Ribosomal RNA adenine dimethylase Glyco_transf_90 PF05686.12 EXF84307.1 - 5e-12 45.4 7.5 1.2e-10 40.9 0.0 2.6 3 0 0 3 3 3 2 Glycosyl transferase family 90 Arginase PF00491.21 EXF84308.1 - 1.2e-74 251.3 0.1 1.4e-74 251.1 0.1 1.0 1 0 0 1 1 1 1 Arginase family MARVEL PF01284.23 EXF84309.1 - 2.8e-07 30.6 17.3 5.4e-07 29.7 17.3 1.5 1 1 0 1 1 1 1 Membrane-associating domain DUF2070 PF09843.9 EXF84309.1 - 0.34 9.2 12.4 0.4 8.9 12.4 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Cnn_1N PF07989.11 EXF84311.1 - 8.3e-22 77.1 9.0 8.3e-22 77.1 9.0 11.9 8 2 2 12 12 12 3 Centrosomin N-terminal motif 1 Mto2_bdg PF12808.7 EXF84311.1 - 5.7e-12 45.7 9.4 5.7e-12 45.7 9.4 13.2 14 2 2 16 16 16 2 Micro-tubular organiser Mto1 C-term Mto2-binding region DegS PF05384.11 EXF84311.1 - 0.0012 18.3 3.4 0.0012 18.3 3.4 7.9 5 1 3 9 9 9 2 Sensor protein DegS ERM PF00769.19 EXF84311.1 - 0.0058 16.5 36.9 0.0058 16.5 36.9 7.1 3 2 4 7 7 7 3 Ezrin/radixin/moesin family DUF1479 PF07350.12 EXF84312.1 - 3.7e-163 543.1 0.0 4.3e-163 542.9 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1479) PhyH PF05721.13 EXF84312.1 - 0.12 12.7 0.2 9.6 6.4 0.0 2.3 2 0 0 2 2 2 0 Phytanoyl-CoA dioxygenase (PhyH) Methyltransf_11 PF08241.12 EXF84313.1 - 5.6e-07 30.1 0.0 1.3e-06 29.0 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF84313.1 - 2.1e-06 27.6 0.0 2.7e-06 27.2 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF84313.1 - 1.4e-05 25.7 0.0 3.5e-05 24.4 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF84313.1 - 0.0055 17.4 0.0 0.0081 16.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EXF84313.1 - 0.1 12.5 0.0 0.19 11.5 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain DUF1993 PF09351.10 EXF84314.1 - 1.4e-53 181.3 0.0 1.6e-53 181.1 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1993) DUF2235 PF09994.9 EXF84315.1 - 9e-101 337.0 0.2 1.3e-100 336.5 0.2 1.2 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) An_peroxidase PF03098.15 EXF84316.1 - 1.7e-39 135.8 0.0 6.8e-22 77.7 0.0 3.9 1 1 2 3 3 3 3 Animal haem peroxidase p450 PF00067.22 EXF84316.1 - 6.2e-06 25.2 0.1 2.2e-05 23.4 0.0 1.8 2 0 0 2 2 2 1 Cytochrome P450 CDH-cyt PF16010.5 EXF84317.1 - 3.5e-56 189.8 4.2 3.5e-56 189.8 4.2 2.2 3 0 0 3 3 3 1 Cytochrome domain of cellobiose dehydrogenase GMC_oxred_N PF00732.19 EXF84317.1 - 9.3e-33 113.9 0.0 1.8e-32 112.9 0.0 1.5 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EXF84317.1 - 1.5e-20 74.2 0.4 6.4e-20 72.2 0.5 2.0 2 0 0 2 2 2 1 GMC oxidoreductase FAD_binding_2 PF00890.24 EXF84317.1 - 3.9e-06 26.2 2.4 1.4e-05 24.4 1.3 2.3 3 0 0 3 3 3 1 FAD binding domain DAO PF01266.24 EXF84317.1 - 2.4e-05 24.1 3.3 0.00011 22.0 3.3 2.0 1 1 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 EXF84317.1 - 4.8e-05 22.2 1.4 0.00028 19.7 1.1 2.0 2 0 0 2 2 2 1 HI0933-like protein NAD_binding_8 PF13450.6 EXF84317.1 - 0.00088 19.5 0.6 0.00088 19.5 0.6 2.2 2 0 0 2 2 1 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 EXF84317.1 - 0.0047 16.3 1.7 0.0082 15.5 0.8 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 EXF84317.1 - 0.0053 15.9 0.7 0.01 14.9 0.5 1.6 1 1 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_2 PF07992.14 EXF84317.1 - 0.011 15.0 0.5 0.036 13.3 0.3 1.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EXF84317.1 - 0.015 14.5 0.2 0.028 13.7 0.2 1.4 1 0 0 1 1 1 0 FAD binding domain ApbA PF02558.16 EXF84317.1 - 0.062 12.9 0.1 0.19 11.4 0.1 1.9 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA SEEEED PF14797.6 EXF84317.1 - 0.38 10.9 8.7 0.85 9.8 8.7 1.5 1 0 0 1 1 1 0 Serine-rich region of AP3B1, clathrin-adaptor complex Pyr_redox PF00070.27 EXF84317.1 - 0.41 11.2 1.8 0.66 10.6 0.6 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Inhibitor_I36 PF03995.13 EXF84318.1 - 0.12 12.3 2.9 7.6 6.5 0.0 2.7 1 1 1 2 2 2 0 Peptidase inhibitor family I36 Pyr_redox_2 PF07992.14 EXF84319.1 - 7.1e-29 101.0 0.0 1.1e-28 100.3 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EXF84319.1 - 8e-13 48.8 0.4 6.1e-11 42.7 0.1 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EXF84319.1 - 7.7e-06 25.4 0.0 1.5e-05 24.4 0.0 1.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EXF84319.1 - 9e-05 21.8 0.0 0.00013 21.2 0.0 1.3 1 0 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) Lycopene_cycl PF05834.12 EXF84319.1 - 0.017 14.2 0.0 0.87 8.6 0.0 2.3 1 1 1 2 2 2 0 Lycopene cyclase protein Trp_halogenase PF04820.14 EXF84319.1 - 0.021 13.7 0.2 3.9 6.2 0.0 2.4 2 1 1 3 3 3 0 Tryptophan halogenase DUF1188 PF06690.11 EXF84319.1 - 0.025 14.1 0.0 2.5 7.6 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1188) DAO PF01266.24 EXF84319.1 - 0.08 12.5 0.1 5 6.6 0.0 2.8 3 0 0 3 3 3 0 FAD dependent oxidoreductase Ank_2 PF12796.7 EXF84320.1 - 1.4e-39 134.5 0.8 5.3e-10 39.8 0.0 4.5 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EXF84320.1 - 2.3e-27 92.0 0.7 0.00025 21.2 0.0 7.6 8 0 0 8 8 8 6 Ankyrin repeat Ank_4 PF13637.6 EXF84320.1 - 1.6e-23 82.8 5.6 4.2e-09 36.8 0.1 6.9 3 2 5 8 8 8 6 Ankyrin repeats (many copies) Ank_5 PF13857.6 EXF84320.1 - 1.6e-23 82.4 6.1 2.4e-05 24.5 0.0 7.4 2 1 7 9 9 9 6 Ankyrin repeats (many copies) Ank PF00023.30 EXF84320.1 - 3.1e-22 78.0 4.6 0.00081 19.7 0.0 8.1 9 1 0 9 9 9 5 Ankyrin repeat Glyco_hydro_43 PF04616.14 EXF84321.1 - 9.5e-50 169.5 8.4 1.5e-49 168.9 8.4 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 CBM_6 PF03422.15 EXF84321.1 - 2.7e-36 124.6 1.9 2.7e-36 124.6 1.9 2.0 2 0 0 2 2 2 1 Carbohydrate binding module (family 6) DUF5010_C PF18099.1 EXF84321.1 - 2.1e-07 31.0 1.2 3.5e-07 30.3 0.1 1.9 2 0 0 2 2 2 1 DUF5010 C-terminal domain Glyco_hydro_32N PF00251.20 EXF84321.1 - 0.0034 17.0 6.6 0.0042 16.7 5.6 1.6 1 1 0 1 1 1 1 Glycosyl hydrolases family 32 N-terminal domain HLH PF00010.26 EXF84323.1 - 2.1e-12 46.8 0.2 3.8e-12 46.0 0.2 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Aldedh PF00171.22 EXF84324.1 - 1.3e-105 353.6 0.0 1.6e-105 353.3 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family PhoD PF09423.10 EXF84325.1 - 3e-05 23.2 1.8 0.0032 16.5 0.1 2.4 3 0 0 3 3 3 2 PhoD-like phosphatase Ank_2 PF12796.7 EXF84326.1 - 3.2e-51 171.8 11.4 8.2e-14 52.0 0.1 4.9 1 1 5 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EXF84326.1 - 3.6e-45 151.8 9.1 2.8e-12 46.9 0.1 8.7 3 1 6 9 9 9 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 EXF84326.1 - 1.2e-39 129.7 4.3 2.4e-05 24.4 0.0 10.6 10 1 0 10 10 10 7 Ankyrin repeat Ank PF00023.30 EXF84326.1 - 4.9e-39 131.1 20.1 4.9e-06 26.7 0.2 10.1 10 1 0 10 10 10 6 Ankyrin repeat Ank_5 PF13857.6 EXF84326.1 - 2e-36 123.6 13.6 8.8e-10 38.7 0.4 6.9 5 1 2 7 7 7 5 Ankyrin repeats (many copies) RVP PF00077.20 EXF84326.1 - 0.0049 17.2 0.1 1.8 8.9 0.0 3.1 1 1 1 2 2 2 1 Retroviral aspartyl protease DUF2384 PF09722.10 EXF84326.1 - 0.027 14.5 0.4 1.6 8.8 0.0 3.6 4 0 0 4 4 4 0 Protein of unknown function (DUF2384) Per1 PF04080.13 EXF84327.1 - 1.1e-103 346.5 5.4 1.4e-103 346.2 5.4 1.1 1 0 0 1 1 1 1 Per1-like family DUF4401 PF14351.6 EXF84327.1 - 0.59 9.4 11.5 0.09 12.1 7.4 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4401) DUF3681 PF12442.8 EXF84327.1 - 0.78 10.2 8.1 1.1 9.7 3.8 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF3681) DUF1772 PF08592.11 EXF84328.1 - 1.3e-07 32.0 2.8 6.9e-07 29.7 2.8 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF1772) Methyltransf_23 PF13489.6 EXF84329.1 - 9e-18 64.6 0.0 1.3e-17 64.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF84329.1 - 1.1e-09 38.8 0.0 2.7e-09 37.6 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF84329.1 - 8.1e-09 35.4 0.0 1.1e-07 31.8 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF84329.1 - 1.5e-07 32.1 0.0 8.6e-07 29.6 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF84329.1 - 3.5e-06 27.6 0.0 6e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 EXF84329.1 - 0.0076 15.7 0.0 0.018 14.5 0.0 1.6 1 0 0 1 1 1 1 Putative methyltransferase MTS PF05175.14 EXF84329.1 - 0.02 14.5 0.0 0.039 13.5 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase small domain PCMT PF01135.19 EXF84329.1 - 0.092 12.5 0.0 1.4 8.6 0.0 2.1 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CMAS PF02353.20 EXF84329.1 - 0.13 11.6 0.0 0.33 10.2 0.0 1.7 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase GidB PF02527.15 EXF84329.1 - 0.19 11.0 0.0 1.2 8.4 0.0 2.1 1 1 0 1 1 1 0 rRNA small subunit methyltransferase G Methyltransf_23 PF13489.6 EXF84330.1 - 8.8e-20 71.2 0.0 1.4e-19 70.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF84330.1 - 6.7e-10 39.5 0.0 3.3e-05 24.5 0.0 2.5 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_31 PF13847.6 EXF84330.1 - 6.9e-08 32.4 0.0 9e-05 22.3 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 EXF84330.1 - 1.5e-06 28.8 0.0 2.3e-05 25.1 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF84330.1 - 6.6e-06 26.7 0.0 0.00035 21.2 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 EXF84330.1 - 0.017 14.6 0.0 0.14 11.7 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase small domain CheR PF01739.18 EXF84330.1 - 0.082 12.4 0.0 0.14 11.6 0.0 1.3 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain Ubie_methyltran PF01209.18 EXF84330.1 - 0.17 11.2 0.0 21 4.3 0.0 2.8 3 0 0 3 3 3 0 ubiE/COQ5 methyltransferase family PCMT PF01135.19 EXF84330.1 - 0.22 11.2 0.0 16 5.2 0.0 2.1 2 0 0 2 2 2 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_23 PF13489.6 EXF84331.1 - 3.6e-24 85.4 0.0 6.3e-24 84.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF84331.1 - 2.4e-12 47.4 0.0 4.4e-12 46.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF84331.1 - 4.5e-11 42.8 0.0 1.3e-10 41.2 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF84331.1 - 9.2e-10 39.1 0.0 1.6e-09 38.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF84331.1 - 8.2e-09 36.1 0.0 2.2e-08 34.7 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EXF84331.1 - 0.00028 20.5 0.0 0.013 15.1 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase small domain PrmA PF06325.13 EXF84331.1 - 0.0044 16.5 0.0 0.007 15.8 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) FtsJ PF01728.19 EXF84331.1 - 0.012 15.8 0.0 0.016 15.3 0.0 1.2 1 0 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_4 PF02390.17 EXF84331.1 - 0.018 14.5 0.0 0.31 10.5 0.0 2.2 2 0 0 2 2 2 0 Putative methyltransferase Ubie_methyltran PF01209.18 EXF84331.1 - 0.028 13.7 0.0 0.4 10.0 0.0 2.3 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_2 PF00891.18 EXF84331.1 - 0.043 13.1 0.0 0.077 12.3 0.0 1.4 1 0 0 1 1 1 0 O-methyltransferase domain Methyltransf_16 PF10294.9 EXF84331.1 - 0.059 13.1 0.0 0.096 12.4 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase adh_short_C2 PF13561.6 EXF84332.1 - 1.8e-38 132.4 0.6 4.1e-38 131.2 0.6 1.5 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF84332.1 - 9.2e-32 110.1 0.4 2.3e-31 108.8 0.3 1.7 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.10 EXF84332.1 - 4.7e-09 36.4 0.8 6.3e-08 32.7 0.8 2.3 1 1 0 1 1 1 1 KR domain His_Phos_2 PF00328.22 EXF84332.1 - 0.014 14.8 1.2 1.9 7.7 0.0 2.8 1 1 1 2 2 2 0 Histidine phosphatase superfamily (branch 2) Polysacc_synt_2 PF02719.15 EXF84332.1 - 0.016 14.4 0.0 0.026 13.7 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Tail_spike_N PF18668.1 EXF84332.1 - 0.046 13.6 0.2 0.14 12.1 0.2 1.8 1 0 0 1 1 1 0 Tail spike TSP1/Gp66 receptor binding N-terminal domain PDGLE PF13190.6 EXF84332.1 - 0.088 12.7 0.2 0.24 11.3 0.2 1.8 1 0 0 1 1 1 0 PDGLE domain Git3 PF11710.8 EXF84333.1 - 3.1e-18 66.3 10.9 3.1e-18 66.3 10.9 1.5 2 0 0 2 2 2 1 G protein-coupled glucose receptor regulating Gpa2 GPR_Gpa2_C PF11970.8 EXF84333.1 - 2.1e-09 37.3 0.2 2.1e-09 37.3 0.2 2.6 4 0 0 4 4 4 1 G protein-coupled glucose receptor regulating Gpa2 C-term 7tm_1 PF00001.21 EXF84333.1 - 7.7e-09 35.3 4.3 7.7e-09 35.3 4.3 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) CFEM PF05730.11 EXF84334.1 - 3.4e-14 52.7 13.4 3.4e-14 52.7 13.4 1.8 2 0 0 2 2 2 1 CFEM domain Adeno_PV PF03910.13 EXF84334.1 - 0.13 10.9 4.8 0.16 10.7 4.8 1.1 1 0 0 1 1 1 0 Adenovirus minor core protein PV Sporozoite_P67 PF05642.11 EXF84334.1 - 1.2 7.2 6.6 1.2 7.1 6.6 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Strumpellin PF10266.9 EXF84336.1 - 0.07 10.8 0.1 0.12 10.0 0.0 1.3 2 0 0 2 2 2 0 Hereditary spastic paraplegia protein strumpellin Zn_clus PF00172.18 EXF84337.1 - 3.9e-09 36.5 8.4 9.4e-09 35.3 8.4 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EXF84337.1 - 0.0074 15.4 0.1 0.033 13.2 0.1 2.1 1 1 0 1 1 1 1 Fungal specific transcription factor domain Sigma70_r1_1 PF03979.14 EXF84337.1 - 0.14 12.2 0.3 0.28 11.3 0.3 1.4 1 0 0 1 1 1 0 Sigma-70 factor, region 1.1 DIOX_N PF14226.6 EXF84338.1 - 4.8e-28 98.3 0.1 8e-28 97.6 0.1 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EXF84338.1 - 2.6e-21 76.0 0.2 7.2e-21 74.6 0.0 1.8 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily Acyltransferase PF01553.21 EXF84338.1 - 0.14 11.8 0.0 0.26 10.9 0.0 1.3 1 0 0 1 1 1 0 Acyltransferase MFS_1 PF07690.16 EXF84340.1 - 4.1e-31 108.2 32.8 4.1e-31 108.2 32.8 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF84340.1 - 2.4e-07 30.0 13.8 2.4e-07 30.0 13.8 3.8 2 2 2 4 4 4 1 Sugar (and other) transporter DUF1269 PF06897.12 EXF84340.1 - 0.76 10.1 2.8 1.4 9.3 0.7 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1269) Gly-zipper_YMGG PF13441.6 EXF84340.1 - 0.86 9.4 7.3 2.5 7.9 3.9 3.0 2 0 0 2 2 2 0 YMGG-like Gly-zipper Gly-zipper_Omp PF13488.6 EXF84340.1 - 2.3 8.3 9.3 2.5 8.2 5.0 3.2 2 1 0 2 2 2 0 Glycine zipper ORC4_C PF14629.6 EXF84345.1 - 5.9e-65 218.7 0.0 1.1e-64 217.8 0.0 1.5 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 4 C-terminus INCENP_ARK-bind PF03941.15 EXF84345.1 - 2.1e-18 66.0 0.9 2.1e-18 66.0 0.9 3.7 5 0 0 5 5 2 1 Inner centromere protein, ARK binding region AAA_16 PF13191.6 EXF84345.1 - 8.1e-12 45.8 0.1 8.1e-12 45.8 0.1 3.3 3 0 0 3 3 3 1 AAA ATPase domain PHD PF00628.29 EXF84345.1 - 1.1e-10 41.3 5.9 2.1e-10 40.3 5.9 1.5 1 0 0 1 1 1 1 PHD-finger AAA_22 PF13401.6 EXF84345.1 - 5e-09 36.5 0.0 2.4e-08 34.3 0.0 2.2 2 0 0 2 2 1 1 AAA domain AAA PF00004.29 EXF84345.1 - 2.7e-08 34.3 0.0 7.6e-08 32.9 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) PHD_2 PF13831.6 EXF84345.1 - 2.9e-08 33.1 1.8 5.2e-08 32.3 1.8 1.5 1 0 0 1 1 1 1 PHD-finger NACHT PF05729.12 EXF84345.1 - 5.7e-07 29.6 0.0 1.7e-06 28.1 0.0 1.8 1 1 0 1 1 1 1 NACHT domain AAA_19 PF13245.6 EXF84345.1 - 2.1e-06 28.2 0.5 6e-06 26.7 0.1 2.0 2 0 0 2 2 1 1 AAA domain KAP_NTPase PF07693.14 EXF84345.1 - 3.8e-05 23.1 0.7 9.7e-05 21.7 0.0 2.0 2 0 0 2 2 2 1 KAP family P-loop domain ATPase_2 PF01637.18 EXF84345.1 - 0.00017 21.6 0.0 0.00017 21.6 0.0 2.2 2 0 0 2 2 1 1 ATPase domain predominantly from Archaea NB-ARC PF00931.22 EXF84345.1 - 0.0009 18.5 0.1 0.0024 17.1 0.1 1.6 1 0 0 1 1 1 1 NB-ARC domain AAA_14 PF13173.6 EXF84345.1 - 0.0031 17.6 0.0 0.01 15.9 0.0 1.9 1 1 0 1 1 1 1 AAA domain FYVE_2 PF02318.16 EXF84345.1 - 0.0081 16.4 1.8 0.0081 16.4 1.8 2.8 3 0 0 3 3 1 1 FYVE-type zinc finger zf-HC5HC2H PF13771.6 EXF84345.1 - 0.014 15.6 0.8 0.036 14.3 0.8 1.6 1 0 0 1 1 1 0 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 EXF84345.1 - 0.058 13.6 0.5 0.13 12.4 0.5 1.5 1 0 0 1 1 1 0 PHD-zinc-finger like domain PduV-EutP PF10662.9 EXF84345.1 - 0.12 12.2 0.0 0.32 10.7 0.0 1.7 1 1 1 2 2 2 0 Ethanolamine utilisation - propanediol utilisation ABC_tran PF00005.27 EXF84345.1 - 0.16 12.5 2.5 0.32 11.5 0.0 2.8 2 0 0 2 2 1 0 ABC transporter Prok-RING_1 PF14446.6 EXF84345.1 - 0.3 11.0 3.2 0.65 10.0 3.2 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 C1_1 PF00130.22 EXF84345.1 - 0.41 10.6 4.5 0.076 12.9 0.7 1.7 2 0 0 2 2 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_2 PF03107.16 EXF84345.1 - 0.53 10.7 1.9 1.1 9.6 1.9 1.5 1 0 0 1 1 1 0 C1 domain zf-RING_2 PF13639.6 EXF84345.1 - 2.8 8.4 4.9 5.9 7.3 4.9 1.6 1 0 0 1 1 1 0 Ring finger domain SMC_N PF02463.19 EXF84346.1 - 7.3e-69 231.6 9.8 2.4e-67 226.6 9.8 2.8 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EXF84346.1 - 6.8e-20 71.5 5.6 7.3e-20 71.4 0.3 3.2 3 0 0 3 3 3 1 SMC proteins Flexible Hinge Domain AAA_23 PF13476.6 EXF84346.1 - 2e-10 41.5 17.6 2e-10 41.5 17.6 6.8 2 2 1 3 3 3 1 AAA domain AAA_21 PF13304.6 EXF84346.1 - 2.2e-09 37.6 9.3 0.00016 21.6 0.2 3.9 3 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EXF84346.1 - 0.00013 21.7 0.1 0.0003 20.5 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain MscS_porin PF12795.7 EXF84346.1 - 0.0022 17.6 22.0 0.0022 17.6 22.0 6.6 2 2 3 7 7 7 2 Mechanosensitive ion channel porin domain HIP1_clath_bdg PF16515.5 EXF84346.1 - 0.01 16.4 6.3 0.01 16.4 6.3 8.8 3 2 6 9 9 9 0 Clathrin-binding domain of Huntingtin-interacting protein 1 HSBP1 PF06825.12 EXF84346.1 - 0.032 14.1 0.5 0.032 14.1 0.5 4.0 4 0 0 4 4 4 0 Heat shock factor binding protein 1 ABC_tran PF00005.27 EXF84346.1 - 0.13 12.8 0.0 0.13 12.8 0.0 6.1 4 2 0 4 4 4 0 ABC transporter FDX-ACB PF03147.14 EXF84346.1 - 1.9 9.0 11.9 0.61 10.5 2.3 4.2 4 0 0 4 4 4 0 Ferredoxin-fold anticodon binding domain MOSC PF03473.17 EXF84347.1 - 9.6e-23 80.6 0.0 1.6e-22 79.9 0.0 1.3 1 0 0 1 1 1 1 MOSC domain MOSC_N PF03476.16 EXF84347.1 - 2.3e-11 43.6 0.0 5e-11 42.5 0.0 1.6 1 0 0 1 1 1 1 MOSC N-terminal beta barrel domain Fungal_trans_2 PF11951.8 EXF84348.1 - 8.4e-11 41.3 1.6 4.8e-10 38.8 1.6 2.1 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF84348.1 - 9.2e-07 28.9 10.0 1.6e-06 28.1 10.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Mob1_phocein PF03637.17 EXF84349.1 - 4.6e-22 78.8 0.2 7.7e-22 78.1 0.2 1.3 1 0 0 1 1 1 1 Mob1/phocein family CxC6 PF18721.1 EXF84349.1 - 0.16 12.2 3.6 0.35 11.2 3.6 1.5 1 0 0 1 1 1 0 CxC6 like cysteine cluster associated with KDZ transposases cobW PF02492.19 EXF84350.1 - 1.9e-47 161.2 0.2 2.5e-47 160.7 0.2 1.2 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain RsgA_GTPase PF03193.16 EXF84350.1 - 1.6e-05 24.9 0.2 0.14 12.0 0.0 2.6 2 1 0 2 2 2 2 RsgA GTPase CobW_C PF07683.14 EXF84350.1 - 0.00027 20.8 0.0 0.00051 19.9 0.0 1.5 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain AAA_16 PF13191.6 EXF84350.1 - 0.0065 16.9 0.0 0.038 14.4 0.0 2.2 2 1 1 3 3 3 1 AAA ATPase domain MMR_HSR1 PF01926.23 EXF84350.1 - 0.0082 16.2 0.0 0.017 15.2 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase ATP_bind_1 PF03029.17 EXF84350.1 - 0.0097 15.7 0.4 0.48 10.2 0.1 2.5 2 1 0 2 2 2 1 Conserved hypothetical ATP binding protein AAA_23 PF13476.6 EXF84350.1 - 0.011 16.2 0.1 0.024 15.1 0.1 1.6 1 0 0 1 1 1 0 AAA domain MeaB PF03308.16 EXF84350.1 - 0.012 14.6 0.7 2.9 6.8 0.1 2.9 3 0 0 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB GTP_EFTU PF00009.27 EXF84350.1 - 0.022 14.3 0.1 4.9 6.6 0.0 2.5 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain Septin PF00735.18 EXF84350.1 - 0.036 13.3 0.6 8.7 5.5 0.0 2.5 2 1 0 2 2 2 0 Septin AAA_22 PF13401.6 EXF84350.1 - 0.044 14.0 0.1 0.35 11.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 EXF84350.1 - 0.06 13.1 0.2 0.16 11.7 0.0 1.8 2 0 0 2 2 2 0 P-loop containing region of AAA domain ABC_tran PF00005.27 EXF84350.1 - 0.095 13.2 0.9 0.66 10.5 0.1 2.5 3 0 0 3 3 3 0 ABC transporter TsaE PF02367.17 EXF84350.1 - 0.098 12.7 0.0 0.22 11.5 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_30 PF13604.6 EXF84350.1 - 0.12 12.1 0.8 0.47 10.1 0.1 2.0 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 EXF84350.1 - 0.12 12.9 0.1 0.53 10.8 0.0 2.0 2 0 0 2 2 2 0 AAA domain NOT2_3_5 PF04153.18 EXF84351.1 - 8.4e-28 97.1 0.5 1.4e-27 96.4 0.5 1.3 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family CUE PF02845.16 EXF84352.1 - 4.2e-12 45.5 0.0 6.6e-12 44.9 0.0 1.3 1 0 0 1 1 1 1 CUE domain G2BR PF18442.1 EXF84352.1 - 0.095 12.4 8.6 0.23 11.1 8.6 1.6 1 0 0 1 1 1 0 E3 gp78 Ube2g2-binding region (G2BR) VIR_N PF15912.5 EXF84352.1 - 0.17 11.4 6.9 0.023 14.3 2.5 1.7 2 0 0 2 2 2 0 Virilizer, N-terminal TMEM171 PF15471.6 EXF84352.1 - 0.71 8.8 3.6 0.52 9.2 0.3 1.9 2 0 0 2 2 2 0 Transmembrane protein family 171 zf-C2H2 PF00096.26 EXF84353.1 - 1.2e-14 53.8 18.3 0.00015 22.1 0.4 4.3 4 1 1 5 5 5 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EXF84353.1 - 2.3e-10 40.4 14.2 0.00084 20.0 0.2 4.6 4 1 1 5 5 5 3 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EXF84353.1 - 1.2e-05 25.5 17.7 0.0005 20.4 0.8 4.3 5 0 0 5 5 4 2 Zinc-finger double domain zf-C2H2_6 PF13912.6 EXF84353.1 - 0.00089 19.2 9.0 0.047 13.7 0.1 4.1 4 0 0 4 4 4 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EXF84353.1 - 0.0026 18.0 8.0 6.7 7.1 0.1 4.5 2 1 1 3 3 3 1 Zinc-finger double-stranded RNA-binding zf-BED PF02892.15 EXF84353.1 - 0.025 14.6 3.0 0.025 14.6 3.0 2.4 2 1 0 2 2 2 0 BED zinc finger zf-C2H2_11 PF16622.5 EXF84353.1 - 0.033 14.0 0.1 0.033 14.0 0.1 2.9 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-CHCC PF10276.9 EXF84353.1 - 0.058 13.4 1.6 0.16 12.0 0.1 2.4 2 0 0 2 2 2 0 Zinc-finger domain zf-C2H2_aberr PF17017.5 EXF84353.1 - 0.097 12.8 5.2 0.28 11.3 4.8 1.9 1 1 1 2 2 2 0 Aberrant zinc-finger zf-C2HC_2 PF13913.6 EXF84353.1 - 0.13 12.1 0.3 0.13 12.1 0.3 2.4 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf-C2H2_8 PF15909.5 EXF84353.1 - 0.14 12.5 3.9 0.36 11.2 3.7 1.8 1 1 0 1 1 1 0 C2H2-type zinc ribbon zf-C2H2_2 PF12756.7 EXF84353.1 - 1.1 9.6 6.7 3.6 8.0 5.3 2.4 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-met PF12874.7 EXF84353.1 - 1.2 9.6 10.6 3.5 8.2 0.1 4.2 5 0 0 5 5 4 0 Zinc-finger of C2H2 type zf-LYAR PF08790.11 EXF84353.1 - 2 8.4 8.3 4.1 7.4 0.1 3.7 4 0 0 4 4 4 0 LYAR-type C2HC zinc finger Ank_3 PF13606.6 EXF84354.1 - 1.2e-05 25.2 0.2 0.00088 19.6 0.0 2.9 2 0 0 2 2 2 1 Ankyrin repeat Ank_4 PF13637.6 EXF84354.1 - 2.9e-05 24.5 0.2 0.0014 19.1 0.1 3.0 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank PF00023.30 EXF84354.1 - 0.00017 21.9 0.4 0.021 15.2 0.0 2.7 2 0 0 2 2 2 1 Ankyrin repeat Ank_5 PF13857.6 EXF84354.1 - 0.00061 20.0 0.9 0.043 14.1 0.1 3.2 2 2 2 4 4 4 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EXF84354.1 - 0.00076 20.0 0.0 0.019 15.5 0.0 2.6 2 1 0 3 3 3 1 Ankyrin repeats (3 copies) WD40 PF00400.32 EXF84356.1 - 8.5e-13 48.6 3.5 0.00071 20.3 0.1 4.8 5 0 0 5 5 5 3 WD domain, G-beta repeat PALB2_WD40 PF16756.5 EXF84356.1 - 0.02 13.8 0.1 0.2 10.5 0.0 2.3 2 1 1 3 3 3 0 Partner and localizer of BRCA2 WD40 domain PQQ_3 PF13570.6 EXF84356.1 - 0.057 13.9 0.0 8.8 7.0 0.0 3.7 3 0 0 3 3 3 0 PQQ-like domain Pro-kuma_activ PF09286.11 EXF84357.1 - 6.5e-49 165.9 0.3 1.4e-48 164.8 0.3 1.6 1 0 0 1 1 1 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 EXF84357.1 - 0.00012 21.4 2.2 0.0002 20.7 2.2 1.3 1 0 0 1 1 1 1 Subtilase family HTH_Crp_2 PF13545.6 EXF84357.1 - 0.1 12.6 0.0 0.22 11.5 0.0 1.4 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain Complex1_LYR PF05347.15 EXF84358.1 - 1.6e-20 72.9 3.5 2.1e-20 72.5 3.5 1.2 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 EXF84358.1 - 6e-08 33.3 1.2 6.6e-08 33.2 1.2 1.1 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR_1 PF13232.6 EXF84358.1 - 0.0015 19.0 0.4 0.0019 18.8 0.4 1.2 1 0 0 1 1 1 1 Complex1_LYR-like NA37 PF04245.13 EXF84358.1 - 0.013 15.0 0.2 0.013 15.0 0.2 1.1 1 0 0 1 1 1 0 37-kD nucleoid-associated bacterial protein DNA_pol_lambd_f PF10391.9 EXF84358.1 - 0.068 13.0 0.1 0.91 9.4 0.0 2.2 2 0 0 2 2 2 0 Fingers domain of DNA polymerase lambda VitD-bind_III PF09164.10 EXF84358.1 - 0.14 12.2 0.2 0.22 11.6 0.2 1.3 1 0 0 1 1 1 0 Vitamin D binding protein, domain III Nop14 PF04147.12 EXF84359.1 - 0.2 9.8 7.4 0.38 8.9 7.4 1.3 1 0 0 1 1 1 0 Nop14-like family CBM-like PF14683.6 EXF84360.1 - 1.6e-30 106.2 0.0 3.7e-30 105.0 0.0 1.7 1 0 0 1 1 1 1 Polysaccharide lyase family 4, domain III fn3_3 PF14686.6 EXF84360.1 - 6.2e-09 35.5 0.3 2.2e-08 33.7 0.3 2.0 1 0 0 1 1 1 1 Polysaccharide lyase family 4, domain II CarboxypepD_reg PF13620.6 EXF84360.1 - 3.6e-07 30.4 2.5 0.00016 21.9 0.3 3.1 3 0 0 3 3 3 2 Carboxypeptidase regulatory-like domain Fungal_trans PF04082.18 EXF84361.1 - 6.4e-09 35.2 0.1 6.4e-09 35.2 0.1 1.9 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF84361.1 - 0.0023 18.0 8.0 0.0043 17.1 8.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RRM_1 PF00076.22 EXF84363.1 - 1.4e-15 56.8 0.0 1.4e-12 47.2 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_Rrp7 PF17799.1 EXF84363.1 - 0.099 12.4 0.0 0.8 9.5 0.0 2.4 3 0 0 3 3 3 0 Rrp7 RRM-like N-terminal domain RRM_occluded PF16842.5 EXF84363.1 - 0.11 12.4 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 Occluded RNA-recognition motif Ras PF00071.22 EXF84365.1 - 1.2e-51 174.6 0.0 1.4e-51 174.3 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EXF84365.1 - 9e-20 71.1 0.0 1.4e-19 70.5 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EXF84365.1 - 5.2e-11 42.3 0.0 6.1e-11 42.1 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EXF84365.1 - 2e-05 24.2 0.3 0.00019 21.0 0.1 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EXF84365.1 - 0.00017 21.5 0.0 0.68 9.8 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EXF84365.1 - 0.00034 20.7 0.0 0.00058 19.9 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_33 PF13671.6 EXF84365.1 - 0.0056 16.8 0.0 0.01 16.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain NB-ARC PF00931.22 EXF84365.1 - 0.044 13.0 0.0 0.075 12.2 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain AAA_16 PF13191.6 EXF84365.1 - 0.048 14.0 0.0 0.24 11.7 0.0 2.1 2 1 0 2 2 2 0 AAA ATPase domain Scytalone_dh PF02982.14 EXF84365.1 - 0.049 13.4 0.0 0.18 11.6 0.0 1.8 2 0 0 2 2 2 0 Scytalone dehydratase AAA_22 PF13401.6 EXF84365.1 - 0.11 12.8 0.2 1.6 9.0 0.1 2.6 2 1 0 2 2 2 0 AAA domain RGS PF00615.19 EXF84368.1 - 5e-38 130.0 0.7 1.9e-37 128.1 0.0 2.4 3 0 0 3 3 3 1 Regulator of G protein signaling domain DEP PF00610.21 EXF84368.1 - 1.1e-25 89.5 0.0 1.7e-21 76.0 0.0 3.5 3 0 0 3 3 3 2 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Replic_Relax PF13814.6 EXF84368.1 - 0.00078 19.5 0.0 0.37 10.8 0.0 2.6 2 0 0 2 2 2 2 Replication-relaxation DUF3458 PF11940.8 EXF84368.1 - 0.014 15.8 1.2 1.1 9.8 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF3458) Ig-like fold zf_Rg PF17915.1 EXF84369.1 - 0.3 10.5 5.2 0.23 10.9 0.4 2.8 3 0 0 3 3 3 0 Reverse gyrase zinc finger FMN_dh PF01070.18 EXF84370.1 - 1.1e-87 294.3 1.2 1.6e-48 165.5 0.0 2.1 1 1 1 2 2 2 2 FMN-dependent dehydrogenase IMPDH PF00478.25 EXF84370.1 - 0.0032 16.5 0.0 0.007 15.4 0.0 1.5 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain Glu_synthase PF01645.17 EXF84370.1 - 0.0052 16.0 0.0 0.0083 15.3 0.0 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase His_biosynth PF00977.21 EXF84370.1 - 0.018 14.5 0.2 0.31 10.5 0.0 2.4 2 1 1 3 3 3 0 Histidine biosynthesis protein DHO_dh PF01180.21 EXF84370.1 - 0.17 11.1 0.6 1.6 7.9 0.0 2.4 2 1 0 3 3 3 0 Dihydroorotate dehydrogenase Glyco_hydro_106 PF17132.4 EXF84372.1 - 1.4e-21 76.5 0.1 1.5e-20 73.1 0.3 2.3 2 1 0 2 2 2 1 alpha-L-rhamnosidase DUF5057 PF16480.5 EXF84372.1 - 0.0061 16.0 0.0 0.019 14.4 0.0 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF5057) Glyco_hydro_2_N PF02837.18 EXF84372.1 - 0.033 14.1 0.1 0.12 12.3 0.0 2.0 2 0 0 2 2 2 0 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_35 PF01301.19 EXF84373.1 - 1.5e-87 294.2 0.0 2e-87 293.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 BetaGal_dom2 PF10435.9 EXF84373.1 - 2.4e-54 183.9 0.0 4.1e-54 183.1 0.0 1.3 1 0 0 1 1 1 1 Beta-galactosidase, domain 2 BetaGal_dom4_5 PF13364.6 EXF84373.1 - 1.2e-53 180.5 3.7 5e-31 107.6 0.1 2.5 2 0 0 2 2 2 2 Beta-galactosidase jelly roll domain BetaGal_dom3 PF13363.6 EXF84373.1 - 2.6e-15 55.7 0.0 5.6e-15 54.7 0.0 1.6 1 0 0 1 1 1 1 Beta-galactosidase, domain 3 GRDP-like PF07173.12 EXF84374.1 - 4.8e-07 30.5 3.9 0.0016 19.1 0.4 3.3 2 1 1 3 3 3 2 Glycine-rich domain-containing protein-like Peptidase_S9 PF00326.21 EXF84375.1 - 0.00023 20.7 0.0 0.00043 19.8 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Esterase_phd PF10503.9 EXF84375.1 - 0.0025 17.3 0.0 0.015 14.8 0.0 2.3 2 1 0 2 2 2 1 Esterase PHB depolymerase DUF3551 PF12071.8 EXF84375.1 - 0.43 10.7 3.1 4 7.6 1.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3551) ADH_zinc_N_2 PF13602.6 EXF84376.1 - 1.4e-26 94.1 0.0 2.7e-26 93.2 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 EXF84376.1 - 5.8e-22 78.1 0.1 9.2e-21 74.2 0.0 2.4 1 1 1 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EXF84376.1 - 0.00066 19.5 0.0 0.14 12.1 0.0 2.6 2 1 1 3 3 3 2 Alcohol dehydrogenase GroES-like domain Methyltransf_25 PF13649.6 EXF84376.1 - 0.012 16.3 0.0 0.043 14.5 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_11 PF08241.12 EXF84376.1 - 0.043 14.5 0.0 0.14 12.8 0.0 1.9 1 0 0 1 1 1 0 Methyltransferase domain Tannase PF07519.11 EXF84377.1 - 6.6e-95 318.7 0.9 7.6e-95 318.5 0.9 1.0 1 0 0 1 1 1 1 Tannase and feruloyl esterase Peptidase_S9 PF00326.21 EXF84377.1 - 7.7e-06 25.5 0.0 0.0073 15.8 0.0 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 EXF84377.1 - 0.00025 20.4 0.0 0.038 13.3 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EXF84377.1 - 0.0023 17.6 0.1 0.0051 16.5 0.1 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Esterase PF00756.20 EXF84377.1 - 0.037 13.7 0.0 0.064 12.9 0.0 1.3 1 0 0 1 1 1 0 Putative esterase Zn_clus PF00172.18 EXF84378.1 - 2.9e-08 33.7 10.0 4.6e-08 33.0 10.0 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PseudoU_synth_1 PF01416.20 EXF84379.1 - 8.6e-12 45.5 0.0 7.8e-10 39.2 0.0 2.9 3 0 0 3 3 3 1 tRNA pseudouridine synthase DUF2344 PF10105.9 EXF84379.1 - 0.027 14.3 1.6 0.07 13.0 0.0 2.2 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2344) Med22 PF06179.12 EXF84380.1 - 2.8e-14 53.2 0.7 3.6e-06 27.1 0.0 2.1 2 0 0 2 2 2 2 Surfeit locus protein 5 subunit 22 of Mediator complex APH PF01636.23 EXF84381.1 - 1e-08 35.4 0.0 2.2e-08 34.3 0.0 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EXF84381.1 - 0.0088 15.7 0.0 0.02 14.5 0.0 1.5 1 0 0 1 1 1 1 Choline/ethanolamine kinase Fungal_trans PF04082.18 EXF84382.1 - 1.1e-11 44.3 0.0 1.9e-11 43.5 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Fungal_trans_2 PF11951.8 EXF84384.1 - 9.2e-27 93.8 0.0 1e-26 93.7 0.0 1.0 1 0 0 1 1 1 1 Fungal specific transcription factor domain DIOX_N PF14226.6 EXF84387.1 - 1.7e-12 48.1 0.2 3.8e-12 47.0 0.0 1.7 2 0 0 2 2 2 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EXF84387.1 - 4.9e-11 43.0 0.0 8.9e-11 42.2 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily MFS_1 PF07690.16 EXF84388.1 - 1.1e-35 123.2 38.4 1.1e-35 123.2 38.4 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily MFS_4 PF06779.14 EXF84388.1 - 0.063 12.6 19.8 0.068 12.5 8.1 2.7 2 1 1 3 3 3 0 Uncharacterised MFS-type transporter YbfB PrgI PF12666.7 EXF84388.1 - 6.8 7.5 14.3 3.1 8.6 1.8 4.1 3 0 0 3 3 3 0 PrgI family protein FMO-like PF00743.19 EXF84389.1 - 1.5e-30 106.1 0.2 2.2e-15 56.1 0.0 3.0 2 1 0 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EXF84389.1 - 1.4e-13 50.8 0.2 2.6e-09 36.8 0.0 3.1 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EXF84389.1 - 6.9e-11 41.9 0.0 1.5e-10 40.8 0.0 1.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EXF84389.1 - 6.8e-05 22.2 0.3 0.56 9.3 0.0 3.5 3 1 0 3 3 3 3 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 EXF84389.1 - 0.00036 20.7 0.0 0.00075 19.7 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 EXF84389.1 - 0.0015 18.5 0.1 0.23 11.5 0.1 3.3 3 0 0 3 3 3 1 FAD-NAD(P)-binding Glu_dehyd_C PF16912.5 EXF84389.1 - 0.015 14.8 0.0 0.033 13.7 0.0 1.5 1 0 0 1 1 1 0 Glucose dehydrogenase C-terminus DAO PF01266.24 EXF84389.1 - 0.028 14.0 0.3 0.42 10.2 0.4 2.4 2 1 1 3 3 3 0 FAD dependent oxidoreductase HI0933_like PF03486.14 EXF84389.1 - 0.19 10.4 0.1 0.34 9.6 0.1 1.4 1 0 0 1 1 1 0 HI0933-like protein p450 PF00067.22 EXF84390.1 - 3.2e-78 263.5 0.0 3.7e-78 263.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Flavokinase PF01687.17 EXF84391.1 - 9.5e-13 48.4 0.0 1.8e-12 47.5 0.0 1.4 1 0 0 1 1 1 1 Riboflavin kinase Pox_G9-A16 PF03003.16 EXF84392.1 - 0.056 13.2 0.3 1.6 8.5 0.0 2.1 2 0 0 2 2 2 0 Pox virus entry-fusion-complex G9/A16 MFS_1 PF07690.16 EXF84393.1 - 5.8e-28 97.8 44.8 5.8e-28 97.8 44.8 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily FAD_binding_3 PF01494.19 EXF84394.1 - 7.9e-19 68.1 0.0 4.1e-09 36.2 0.1 2.1 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.24 EXF84394.1 - 2.8e-06 27.2 2.7 0.0001 22.0 0.7 2.4 1 1 1 2 2 2 2 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EXF84394.1 - 0.00026 21.0 0.0 0.00056 19.9 0.0 1.6 1 0 0 1 1 1 1 FAD-NAD(P)-binding Amino_oxidase PF01593.24 EXF84394.1 - 0.002 17.5 2.0 0.0092 15.3 0.0 2.5 3 1 0 3 3 3 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EXF84394.1 - 0.0084 16.3 0.1 0.025 14.8 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Trp_halogenase PF04820.14 EXF84394.1 - 0.01 14.7 0.4 2.2 7.0 0.3 2.3 2 0 0 2 2 2 0 Tryptophan halogenase Pyr_redox_2 PF07992.14 EXF84394.1 - 0.038 13.2 0.2 1.1 8.4 0.0 2.4 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase adh_short PF00106.25 EXF84396.1 - 1.2e-05 24.9 0.0 6e-05 22.6 0.0 1.9 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF84396.1 - 0.0031 17.1 0.0 0.0057 16.2 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase ApbA PF02558.16 EXF84396.1 - 0.016 14.8 0.0 0.045 13.4 0.0 1.7 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA KR PF08659.10 EXF84396.1 - 0.022 14.7 0.0 0.037 13.9 0.0 1.4 1 0 0 1 1 1 0 KR domain UPF0731 PF14982.6 EXF84396.1 - 0.15 12.2 0.0 0.48 10.6 0.0 1.8 1 0 0 1 1 1 0 UPF0731 family Anoctamin PF04547.12 EXF84397.1 - 2.3e-105 353.1 2.3 2.8e-105 352.8 2.3 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel DUF4395 PF14340.6 EXF84397.1 - 0.074 13.4 2.3 0.18 12.1 0.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4395) AP_endonuc_2 PF01261.24 EXF84398.1 - 4e-37 127.7 0.0 4.9e-37 127.4 0.0 1.1 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel NTP_transf_6 PF06042.11 EXF84399.1 - 3e-51 173.4 0.0 3.7e-51 173.1 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyltransferase Ank_2 PF12796.7 EXF84400.1 - 3e-30 104.6 1.4 1.4e-14 54.4 0.2 4.3 3 1 1 4 4 4 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EXF84400.1 - 1.7e-22 77.0 4.3 3.4e-06 27.0 0.0 7.4 7 0 0 7 7 7 5 Ankyrin repeat Ank PF00023.30 EXF84400.1 - 6.8e-22 76.9 8.8 9.8e-05 22.6 0.0 6.8 6 0 0 6 6 6 4 Ankyrin repeat Ank_4 PF13637.6 EXF84400.1 - 1.1e-21 76.8 3.1 2.6e-07 31.0 0.0 5.0 2 1 4 6 6 6 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 EXF84400.1 - 5.8e-21 74.3 0.2 0.00012 22.3 0.0 5.6 2 1 3 5 5 5 4 Ankyrin repeats (many copies) PNP_UDP_1 PF01048.20 EXF84400.1 - 2.8e-06 26.8 0.3 1.1e-05 24.8 0.3 1.9 1 1 0 1 1 1 1 Phosphorylase superfamily XylR_N PF06505.11 EXF84401.1 - 0.19 11.5 0.0 1.7 8.4 0.0 2.1 1 1 0 2 2 2 0 Activator of aromatic catabolism TauD PF02668.16 EXF84402.1 - 3.9e-53 181.0 0.7 5.1e-53 180.6 0.7 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family MFS_1 PF07690.16 EXF84403.1 - 1.8e-28 99.5 16.5 1.8e-28 99.5 16.5 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 EXF84403.1 - 8.8e-05 21.5 1.6 8.8e-05 21.5 1.6 2.7 2 1 0 2 2 2 1 MFS_1 like family UPF0154 PF03672.13 EXF84403.1 - 0.01 15.8 0.5 0.43 10.6 0.0 3.5 4 0 0 4 4 4 0 Uncharacterised protein family (UPF0154) Fungal_trans_2 PF11951.8 EXF84404.1 - 3.5e-06 26.1 0.0 6.9e-06 25.1 0.0 1.5 2 0 0 2 2 2 1 Fungal specific transcription factor domain GFO_IDH_MocA PF01408.22 EXF84405.1 - 4.3e-22 79.2 0.2 7.3e-22 78.4 0.2 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 EXF84405.1 - 1.6e-06 28.1 0.0 3.3e-06 27.1 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain Fungal_trans_2 PF11951.8 EXF84406.1 - 0.00075 18.4 0.0 0.0011 17.8 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Fungal_trans PF04082.18 EXF84406.1 - 0.0023 17.0 0.0 0.003 16.6 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain GMC_oxred_N PF00732.19 EXF84407.1 - 4e-32 111.8 0.0 2.9e-22 79.4 0.0 3.2 3 0 0 3 3 3 3 GMC oxidoreductase GMC_oxred_C PF05199.13 EXF84407.1 - 2e-29 102.9 0.1 3.3e-29 102.3 0.1 1.4 1 0 0 1 1 1 1 GMC oxidoreductase NAD_binding_8 PF13450.6 EXF84407.1 - 0.0001 22.4 0.8 0.0004 20.5 0.8 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EXF84407.1 - 0.00015 21.0 0.1 0.0022 17.1 0.1 2.2 2 0 0 2 2 2 1 FAD binding domain Lycopene_cycl PF05834.12 EXF84407.1 - 0.028 13.5 0.0 0.063 12.3 0.0 1.6 2 0 0 2 2 2 0 Lycopene cyclase protein Pyr_redox_2 PF07992.14 EXF84407.1 - 0.031 13.5 0.0 0.11 11.7 0.0 1.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EXF84407.1 - 0.061 12.6 0.5 1.1 8.5 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.16 EXF84407.1 - 0.1 12.2 0.3 0.19 11.4 0.3 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Glyco_hydro_3_C PF01915.22 EXF84408.1 - 8.5e-48 163.0 0.0 1.7e-47 162.1 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 EXF84408.1 - 1.8e-35 122.8 0.0 2.6e-35 122.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 EXF84408.1 - 5.1e-26 90.6 0.2 9.8e-26 89.7 0.2 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain HTH_12 PF08461.10 EXF84409.1 - 0.15 12.0 0.0 0.26 11.3 0.0 1.4 1 0 0 1 1 1 0 Ribonuclease R winged-helix domain APG17 PF04108.12 EXF84411.1 - 1.8e-136 455.4 1.1 2.1e-136 455.2 1.1 1.0 1 0 0 1 1 1 1 Autophagy protein Apg17 SF-assemblin PF06705.11 EXF84411.1 - 0.0016 17.8 2.5 0.0025 17.2 0.2 2.4 3 1 0 3 3 3 1 SF-assemblin/beta giardin IHO1 PF15771.5 EXF84411.1 - 0.3 9.8 4.0 0.14 10.9 0.1 1.9 2 0 0 2 2 2 0 Interactor of HORMAD1 protein 1 DUF1664 PF07889.12 EXF84411.1 - 1.1 9.2 8.4 0.29 11.2 0.8 3.3 4 1 0 5 5 5 0 Protein of unknown function (DUF1664) Choline_transpo PF04515.12 EXF84412.1 - 1.9e-82 277.1 26.1 1.9e-82 277.1 26.1 2.3 2 1 0 2 2 2 1 Plasma-membrane choline transporter Pex14_N PF04695.13 EXF84412.1 - 0.0094 16.6 3.9 0.028 15.1 3.9 1.8 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Ank_3 PF13606.6 EXF84415.1 - 6.7e-23 78.3 6.9 0.043 14.4 0.1 9.5 10 0 0 10 10 10 6 Ankyrin repeat Ank_2 PF12796.7 EXF84415.1 - 8.9e-23 80.7 0.1 8.1e-05 23.1 0.0 5.8 3 2 3 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EXF84415.1 - 4.1e-16 59.1 4.8 0.0072 16.9 0.0 7.6 6 1 1 7 7 7 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EXF84415.1 - 1.7e-10 40.9 3.6 0.07 13.5 0.1 7.1 7 0 0 7 7 7 3 Ankyrin repeats (many copies) Ank PF00023.30 EXF84415.1 - 1.4e-09 38.0 4.7 1.6 9.3 0.1 7.8 8 1 0 8 8 8 3 Ankyrin repeat Sulfotransfer_4 PF17784.1 EXF84417.1 - 3.8e-62 209.9 0.1 5.1e-62 209.5 0.1 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 EXF84417.1 - 0.00027 21.4 0.0 0.0011 19.3 0.0 1.9 1 1 0 1 1 1 1 Sulfotransferase family B12D PF06522.11 EXF84418.1 - 0.07 12.9 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 NADH-ubiquinone reductase complex 1 MLRQ subunit WSC PF01822.19 EXF84419.1 - 0.11 12.7 1.3 0.2 11.9 1.3 1.4 1 0 0 1 1 1 0 WSC domain RIO1 PF01163.22 EXF84420.1 - 1.4e-69 233.5 0.1 3.5e-69 232.2 0.0 1.7 2 0 0 2 2 2 1 RIO1 family APH PF01636.23 EXF84420.1 - 0.0004 20.4 0.1 0.16 11.8 0.0 2.4 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 EXF84420.1 - 0.015 14.7 0.7 0.65 9.3 0.0 2.8 3 0 0 3 3 3 0 Lipopolysaccharide kinase (Kdo/WaaP) family GlutR_dimer PF00745.20 EXF84420.1 - 0.4 11.2 6.8 1.2 9.7 0.5 2.5 2 0 0 2 2 2 0 Glutamyl-tRNAGlu reductase, dimerisation domain Tyrosinase PF00264.20 EXF84421.1 - 2.6e-47 161.9 0.0 5e-47 161.0 0.0 1.4 2 0 0 2 2 2 1 Common central domain of tyrosinase F-box_4 PF15966.5 EXF84423.1 - 0.0002 21.2 0.0 0.0017 18.2 0.0 2.3 2 0 0 2 2 2 1 F-box F-box-like PF12937.7 EXF84423.1 - 0.001 18.9 0.0 0.0024 17.7 0.0 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EXF84423.1 - 0.027 14.3 0.0 0.064 13.2 0.0 1.7 1 0 0 1 1 1 0 F-box domain F-box-like PF12937.7 EXF84424.1 - 0.00022 21.0 0.0 0.00047 20.0 0.0 1.5 1 0 0 1 1 1 1 F-box-like CAAP1 PF15335.6 EXF84424.1 - 0.028 14.9 0.0 0.063 13.8 0.0 1.6 1 0 0 1 1 1 0 Caspase activity and apoptosis inhibitor 1 F-box PF00646.33 EXF84424.1 - 0.048 13.6 0.2 0.24 11.3 0.1 2.2 2 0 0 2 2 2 0 F-box domain Peptidase_M14 PF00246.24 EXF84425.1 - 7e-75 252.5 0.1 8.4e-75 252.2 0.1 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase K_channel_TID PF07941.11 EXF84425.1 - 0.053 14.0 0.1 0.18 12.3 0.1 1.9 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain HNH_2 PF13391.6 EXF84426.1 - 0.0053 16.9 0.0 0.013 15.6 0.0 1.8 1 1 0 1 1 1 1 HNH endonuclease Dynamin_N PF00350.23 EXF84427.1 - 2.3e-16 60.3 0.0 8.1e-16 58.5 0.0 2.0 1 0 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 EXF84427.1 - 0.00059 19.9 0.1 0.0082 16.2 0.1 2.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.16 EXF84427.1 - 0.0029 17.0 0.0 0.026 13.9 0.0 2.3 2 0 0 2 2 2 1 AIG1 family GTP_EFTU PF00009.27 EXF84427.1 - 0.0071 15.9 0.9 0.59 9.7 0.6 2.7 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain ABC_tran PF00005.27 EXF84427.1 - 0.025 15.1 0.0 0.16 12.5 0.0 2.4 2 0 0 2 2 2 0 ABC transporter RsgA_GTPase PF03193.16 EXF84427.1 - 0.04 13.8 0.0 0.15 12.0 0.0 2.0 1 0 0 1 1 1 0 RsgA GTPase IIGP PF05049.13 EXF84427.1 - 0.051 12.6 0.7 0.27 10.2 0.0 2.3 3 0 0 3 3 3 0 Interferon-inducible GTPase (IIGP) DUF87 PF01935.17 EXF84427.1 - 0.13 12.3 2.3 0.35 10.9 0.0 2.8 3 0 0 3 3 3 0 Helicase HerA, central domain AAA_16 PF13191.6 EXF84427.1 - 0.36 11.2 2.5 0.89 9.9 0.1 2.8 2 2 0 2 2 2 0 AAA ATPase domain Amidohydro_3 PF07969.11 EXF84428.1 - 2.6e-67 228.3 3.4 3e-67 228.1 3.4 1.0 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_1 PF01979.20 EXF84428.1 - 1.9e-13 50.4 0.0 3.7e-08 33.1 0.0 2.6 2 1 0 3 3 3 2 Amidohydrolase family Cutinase PF01083.22 EXF84429.1 - 1.1e-40 139.5 0.4 1.4e-40 139.2 0.4 1.1 1 0 0 1 1 1 1 Cutinase Hydrolase_4 PF12146.8 EXF84429.1 - 0.0033 16.7 0.0 0.005 16.1 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 PE-PPE PF08237.11 EXF84429.1 - 0.013 15.0 0.0 0.02 14.4 0.0 1.2 1 0 0 1 1 1 0 PE-PPE domain Abhydrolase_2 PF02230.16 EXF84429.1 - 0.039 13.7 0.0 0.064 13.0 0.0 1.2 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase MFS_1 PF07690.16 EXF84430.1 - 5.9e-33 114.2 31.8 5.9e-33 114.2 31.8 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily GFO_IDH_MocA_C PF02894.17 EXF84431.1 - 4e-17 62.3 0.3 1.3e-16 60.6 0.3 1.9 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain GFO_IDH_MocA PF01408.22 EXF84431.1 - 4e-16 59.9 0.0 7.6e-16 59.0 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Methyltransf_2 PF00891.18 EXF84432.1 - 8.9e-23 80.7 0.0 1.4e-22 80.1 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain Porin_OmpG_1_2 PF16946.5 EXF84433.1 - 0.18 11.0 0.0 0.26 10.6 0.0 1.2 1 0 0 1 1 1 0 OMPG-porin 1 family DUF3995 PF13160.6 EXF84433.1 - 0.19 12.1 6.8 1 9.7 2.6 2.4 1 1 0 2 2 2 0 Protein of unknown function (DUF3995) Trehalase PF01204.18 EXF84434.1 - 3.9e-10 39.2 0.1 6e-10 38.6 0.1 1.2 1 0 0 1 1 1 1 Trehalase Glyco_hydro_63 PF03200.16 EXF84434.1 - 1.4e-07 30.6 3.8 0.012 14.4 0.0 3.8 2 1 1 3 3 3 3 Glycosyl hydrolase family 63 C-terminal domain EnY2 PF10163.9 EXF84434.1 - 0.046 14.1 0.1 0.17 12.3 0.1 2.0 1 0 0 1 1 1 0 Transcription factor e(y)2 Fungal_trans PF04082.18 EXF84435.1 - 0.0086 15.1 0.3 0.0086 15.1 0.3 2.4 2 0 0 2 2 2 2 Fungal specific transcription factor domain Glyco_hydro_39 PF01229.17 EXF84436.1 - 0.00083 18.1 0.6 0.0014 17.3 0.6 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 39 PHINT_rpt PF14882.6 EXF84436.1 - 1.2 9.5 4.2 14 6.1 0.0 3.3 4 0 0 4 4 4 0 Phage-integrase repeat unit Sugar_tr PF00083.24 EXF84437.1 - 7.1e-64 216.3 17.6 8.9e-64 216.0 17.6 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF84437.1 - 1.6e-16 60.2 27.9 2e-16 59.9 26.6 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 EXF84437.1 - 0.00037 19.9 5.2 0.00037 19.9 5.2 1.6 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB Glyco_hydro_127 PF07944.12 EXF84438.1 - 6.9e-112 374.6 0.2 8.2e-112 374.3 0.2 1.0 1 0 0 1 1 1 1 Beta-L-arabinofuranosidase, GH127 Glyco_hydro_61 PF03443.14 EXF84439.1 - 1.2e-44 152.7 0.7 1.7e-44 152.2 0.7 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 HATPase_c_3 PF13589.6 EXF84440.1 - 3.3e-05 23.7 0.0 9.8e-05 22.2 0.0 1.7 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HET PF06985.11 EXF84441.1 - 8.7e-26 91.0 0.0 1.6e-25 90.2 0.0 1.5 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) MFS_1 PF07690.16 EXF84442.1 - 1.4e-33 116.3 26.5 1.4e-33 116.3 26.5 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily Trp_oprn_chp PF09534.10 EXF84442.1 - 1.2 8.9 11.4 2.3 8.0 3.5 3.1 3 0 0 3 3 3 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) DUF3328 PF11807.8 EXF84443.1 - 1.4e-48 165.5 0.7 1.8e-48 165.2 0.7 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) Melibiase PF02065.18 EXF84444.1 - 3.1e-37 128.3 0.0 4.8e-37 127.7 0.0 1.2 1 0 0 1 1 1 1 Melibiase Glyco_hydro_36N PF16875.5 EXF84444.1 - 1.3e-10 41.3 0.0 2.2e-10 40.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 36 N-terminal domain Melibiase_2 PF16499.5 EXF84444.1 - 0.002 17.4 0.0 0.0045 16.2 0.0 1.5 2 0 0 2 2 2 1 Alpha galactosidase A Glyco_hydro_106 PF17132.4 EXF84446.1 - 3.4e-08 32.3 0.0 8.7e-05 21.0 0.0 2.9 2 1 0 2 2 2 2 alpha-L-rhamnosidase Glyco_hydro_42M PF08532.10 EXF84446.1 - 0.004 16.7 0.0 0.0079 15.7 0.0 1.4 1 0 0 1 1 1 1 Beta-galactosidase trimerisation domain NAD_binding_10 PF13460.6 EXF84447.1 - 1.7e-07 31.3 0.0 3.9e-07 30.1 0.0 1.6 1 1 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EXF84447.1 - 4.4e-05 23.1 0.0 0.015 14.8 0.0 2.1 2 0 0 2 2 2 2 NmrA-like family Epimerase PF01370.21 EXF84447.1 - 0.074 12.5 0.0 1.2 8.5 0.0 2.1 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family Herpes_gp2 PF05955.11 EXF84447.1 - 0.14 11.7 0.0 0.42 10.1 0.0 1.7 2 0 0 2 2 2 0 Equine herpesvirus glycoprotein gp2 RibD_C PF01872.17 EXF84448.1 - 8.6e-19 68.2 0.0 1.5e-18 67.3 0.0 1.4 1 1 0 1 1 1 1 RibD C-terminal domain DHFR_1 PF00186.19 EXF84448.1 - 1.5e-06 28.0 0.0 1.9e-06 27.6 0.0 1.1 1 0 0 1 1 1 1 Dihydrofolate reductase NmrA PF05368.13 EXF84449.1 - 2.2e-17 63.4 0.1 3.6e-17 62.7 0.0 1.3 2 0 0 2 2 2 1 NmrA-like family NAD_binding_10 PF13460.6 EXF84449.1 - 4.9e-09 36.3 0.1 7.9e-09 35.7 0.1 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EXF84449.1 - 0.00017 21.1 0.0 0.00027 20.5 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Phage_tail_NK PF16532.5 EXF84449.1 - 0.012 15.2 0.0 0.021 14.4 0.0 1.4 1 0 0 1 1 1 0 Sf6-type phage tail needle knob or tip of some Caudovirales Mannitol_dh PF01232.23 EXF84449.1 - 0.1 12.8 0.0 0.19 11.9 0.0 1.5 1 0 0 1 1 1 0 Mannitol dehydrogenase Rossmann domain 3Beta_HSD PF01073.19 EXF84449.1 - 0.13 11.2 0.1 0.43 9.5 0.0 1.8 2 0 0 2 2 2 0 3-beta hydroxysteroid dehydrogenase/isomerase family Neur_chan_memb PF02932.16 EXF84450.1 - 0.013 15.6 1.3 0.016 15.3 1.3 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region O-antigen_lig PF13425.6 EXF84450.1 - 0.024 13.5 1.4 0.028 13.2 1.4 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Macoilin PF09726.9 EXF84450.1 - 2.4 6.6 13.1 3.3 6.1 13.1 1.1 1 0 0 1 1 1 0 Macoilin family Presenilin PF01080.17 EXF84450.1 - 5.7 5.6 8.1 6.3 5.4 8.1 1.3 1 0 0 1 1 1 0 Presenilin Hamartin PF04388.12 EXF84450.1 - 6.2 5.4 10.1 7.5 5.1 10.1 1.0 1 0 0 1 1 1 0 Hamartin protein RXLR PF16810.5 EXF84450.1 - 8.7 6.8 11.5 18 5.7 11.5 1.8 1 1 0 1 1 1 0 RXLR phytopathogen effector protein, Avirulence activity Methyltransf_23 PF13489.6 EXF84451.1 - 1.1e-17 64.3 0.0 1.7e-17 63.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF84451.1 - 7e-08 33.1 0.0 1.6e-07 31.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF84451.1 - 1.6e-06 28.0 0.0 3.8e-05 23.5 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF84451.1 - 2.1e-05 25.2 0.0 0.00025 21.7 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF84451.1 - 2.7e-05 24.7 0.0 5.7e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 EXF84451.1 - 0.036 13.6 0.0 0.076 12.5 0.0 1.5 1 0 0 1 1 1 0 Putative methyltransferase MTS PF05175.14 EXF84451.1 - 0.084 12.4 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain PAC3 PF10178.9 EXF84452.1 - 0.05 13.7 0.0 0.095 12.9 0.0 1.4 1 0 0 1 1 1 0 Proteasome assembly chaperone 3 Cutinase PF01083.22 EXF84454.1 - 1.3e-46 158.8 1.5 1.7e-46 158.5 1.5 1.1 1 0 0 1 1 1 1 Cutinase PE-PPE PF08237.11 EXF84454.1 - 0.0012 18.5 0.3 0.0021 17.6 0.3 1.4 1 0 0 1 1 1 1 PE-PPE domain DUF2974 PF11187.8 EXF84454.1 - 0.0062 16.1 0.0 0.0096 15.5 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2974) Abhydrolase_1 PF00561.20 EXF84454.1 - 0.03 14.0 0.0 0.037 13.7 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_3 PF07859.13 EXF84454.1 - 0.051 13.4 0.5 0.085 12.7 0.5 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold Chlorophyllase2 PF12740.7 EXF84454.1 - 0.061 12.2 0.1 0.088 11.7 0.1 1.2 1 0 0 1 1 1 0 Chlorophyllase enzyme VirJ PF06057.11 EXF84454.1 - 0.065 13.1 0.0 0.099 12.5 0.0 1.3 1 0 0 1 1 1 0 Bacterial virulence protein (VirJ) Lipase_3 PF01764.25 EXF84454.1 - 0.071 13.0 0.1 0.092 12.6 0.1 1.3 1 0 0 1 1 1 0 Lipase (class 3) Asp PF00026.23 EXF84455.1 - 0.0023 17.4 0.1 1 8.7 0.0 2.2 2 0 0 2 2 2 2 Eukaryotic aspartyl protease VSP PF03302.13 EXF84455.1 - 0.45 9.3 1.5 0.74 8.6 1.5 1.2 1 0 0 1 1 1 0 Giardia variant-specific surface protein Formyl_trans_N PF00551.19 EXF84456.1 - 3.2e-36 124.8 0.1 4.2e-36 124.4 0.1 1.1 1 0 0 1 1 1 1 Formyl transferase ACT PF01842.25 EXF84456.1 - 8.1e-08 31.9 0.0 1.9e-07 30.7 0.0 1.7 1 0 0 1 1 1 1 ACT domain ACT_6 PF13740.6 EXF84456.1 - 0.034 14.1 0.1 0.21 11.6 0.0 2.3 3 0 0 3 3 3 0 ACT domain ZnuA PF01297.17 EXF84456.1 - 0.19 11.1 0.0 0.26 10.6 0.0 1.2 1 0 0 1 1 1 0 Zinc-uptake complex component A periplasmic HET PF06985.11 EXF84457.1 - 1.8e-08 34.8 0.1 1.8e-08 34.8 0.1 2.6 3 0 0 3 3 3 1 Heterokaryon incompatibility protein (HET) zf-C2H2_jaz PF12171.8 EXF84460.1 - 0.14 12.5 0.0 0.85 10.0 0.0 2.4 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding NOA36 PF06524.12 EXF84460.1 - 3.6 6.8 6.5 6.4 6.0 6.5 1.3 1 0 0 1 1 1 0 NOA36 protein CCDC53 PF10152.9 EXF84460.1 - 5.9 7.3 7.9 1.2 9.5 1.1 2.5 3 0 0 3 3 3 0 Subunit CCDC53 of WASH complex zf-H2C2_2 PF13465.6 EXF84460.1 - 6.4 7.4 7.2 0.97 10.0 0.4 3.1 3 0 0 3 3 3 0 Zinc-finger double domain Dynactin_p62 PF05502.13 EXF84464.1 - 3.2e-208 692.3 3.8 7.4e-208 691.1 3.8 1.5 1 1 0 1 1 1 1 Dynactin p62 family Ribosomal_S7e PF01251.18 EXF84465.1 - 6.2e-82 273.8 0.1 7.3e-82 273.6 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S7e DUF4448 PF14610.6 EXF84466.1 - 1.9e-28 99.5 0.2 4.8e-20 72.1 0.0 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF4448) DUF2207 PF09972.9 EXF84466.1 - 0.097 11.4 0.0 0.15 10.8 0.0 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Pro_CA PF00484.19 EXF84467.1 - 5.1e-51 173.1 0.0 7.2e-51 172.6 0.0 1.2 1 0 0 1 1 1 1 Carbonic anhydrase FR47 PF08445.10 EXF84468.1 - 3.7e-05 23.6 0.0 6.7e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_1 PF00583.25 EXF84468.1 - 0.00011 22.5 0.0 0.00018 21.7 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_3 PF13302.7 EXF84468.1 - 0.15 12.8 0.0 0.2 12.4 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain COesterase PF00135.28 EXF84470.1 - 2.8e-79 267.4 0.0 3.8e-79 266.9 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EXF84470.1 - 2.9e-07 30.6 1.5 6.7e-07 29.4 0.3 2.3 2 1 0 2 2 2 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EXF84470.1 - 0.0077 15.7 0.1 0.094 12.2 0.0 2.3 2 0 0 2 2 2 1 Prolyl oligopeptidase family DUF4265 PF14085.6 EXF84470.1 - 0.11 12.4 0.0 0.21 11.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4265) LDcluster4 PF18306.1 EXF84470.1 - 0.24 11.0 0.0 0.41 10.2 0.0 1.3 1 0 0 1 1 1 0 SLOG cluster4 family bZIP_1 PF00170.21 EXF84471.1 - 0.0039 17.3 8.4 0.016 15.3 8.4 2.0 1 0 0 1 1 1 1 bZIP transcription factor IL2 PF00715.17 EXF84471.1 - 0.11 12.4 0.0 0.25 11.3 0.0 1.5 1 0 0 1 1 1 0 Interleukin 2 bZIP_Maf PF03131.17 EXF84471.1 - 1.4 9.5 7.9 0.24 11.9 3.1 2.2 2 0 0 2 2 2 0 bZIP Maf transcription factor HAD_2 PF13419.6 EXF84472.1 - 7.6e-08 32.6 0.0 1.2e-07 32.0 0.0 1.3 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EXF84472.1 - 0.00011 22.2 0.0 0.00024 21.1 0.0 1.6 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 EXF84472.1 - 0.00072 19.9 0.0 0.0013 19.0 0.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Methyltransf_23 PF13489.6 EXF84474.1 - 1.2e-19 70.7 0.0 1.6e-19 70.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF84474.1 - 1.1e-10 42.1 0.0 3.9e-10 40.3 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF84474.1 - 2.3e-08 34.0 0.0 1.8e-05 24.6 0.0 2.1 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_11 PF08241.12 EXF84474.1 - 2.2e-07 31.4 0.0 8.8e-07 29.5 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF84474.1 - 8.5e-07 29.6 0.0 1.3e-05 25.9 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EXF84474.1 - 0.00057 19.4 0.0 0.0009 18.7 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Ubie_methyltran PF01209.18 EXF84474.1 - 0.00078 18.8 0.0 0.028 13.8 0.0 2.1 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.17 EXF84474.1 - 0.0037 16.8 0.0 0.0081 15.6 0.0 1.5 2 0 0 2 2 2 1 Putative methyltransferase MTS PF05175.14 EXF84474.1 - 0.0043 16.6 0.0 0.007 15.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain FtsJ PF01728.19 EXF84474.1 - 0.0077 16.4 0.0 0.011 15.9 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_16 PF10294.9 EXF84474.1 - 0.013 15.3 0.0 0.033 13.9 0.0 1.5 1 1 0 1 1 1 0 Lysine methyltransferase PCMT PF01135.19 EXF84474.1 - 0.062 13.0 0.0 0.1 12.3 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_2 PF00891.18 EXF84474.1 - 0.096 12.0 0.0 0.22 10.8 0.0 1.6 1 0 0 1 1 1 0 O-methyltransferase domain CMAS PF02353.20 EXF84474.1 - 0.13 11.5 0.0 0.3 10.3 0.0 1.6 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase Vwaint PF14624.6 EXF84474.1 - 0.16 12.1 0.0 0.31 11.2 0.0 1.4 1 0 0 1 1 1 0 VWA / Hh protein intein-like Methyltransf_23 PF13489.6 EXF84475.1 - 7.9e-21 74.6 0.0 1.2e-20 74.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF84475.1 - 1.9e-11 44.5 0.0 5.6e-11 43.0 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF84475.1 - 3.2e-09 36.7 0.0 7.5e-08 32.3 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF84475.1 - 1.5e-07 32.0 0.0 2.7e-07 31.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF84475.1 - 1.1e-06 29.3 0.0 7.5e-06 26.6 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EXF84475.1 - 0.0017 17.9 0.0 0.0033 17.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 EXF84475.1 - 0.0047 16.4 0.0 0.0074 15.7 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Ubie_methyltran PF01209.18 EXF84475.1 - 0.011 15.1 0.0 0.038 13.3 0.0 1.8 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.17 EXF84475.1 - 0.011 15.2 0.0 0.031 13.7 0.0 1.7 2 0 0 2 2 2 0 Putative methyltransferase DUF938 PF06080.12 EXF84475.1 - 0.1 12.4 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF938) Methyltransf_16 PF10294.9 EXF84475.1 - 0.11 12.2 0.0 0.19 11.4 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase FtsJ PF01728.19 EXF84475.1 - 0.11 12.6 0.0 0.19 11.8 0.0 1.4 1 0 0 1 1 1 0 FtsJ-like methyltransferase FAD_binding_4 PF01565.23 EXF84477.1 - 5.3e-25 87.8 4.7 8.5e-25 87.1 4.7 1.3 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EXF84477.1 - 1.6e-05 24.9 0.0 3e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 Berberine and berberine like Methyltransf_23 PF13489.6 EXF84479.1 - 1.9e-22 79.9 0.0 2.9e-22 79.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF84479.1 - 9.4e-12 45.5 0.0 2.6e-11 44.1 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF84479.1 - 1e-08 35.7 0.0 1.8e-08 34.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF84479.1 - 2e-08 34.1 0.0 2.1e-07 30.8 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF84479.1 - 9e-08 32.8 0.0 1e-06 29.4 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EXF84479.1 - 0.00015 21.3 0.0 0.00027 20.4 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 EXF84479.1 - 0.0055 16.3 0.0 0.009 15.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_2 PF00891.18 EXF84479.1 - 0.0099 15.2 0.0 0.018 14.3 0.0 1.4 1 0 0 1 1 1 1 O-methyltransferase domain PCMT PF01135.19 EXF84479.1 - 0.038 13.7 0.0 0.091 12.5 0.0 1.6 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) GidB PF02527.15 EXF84479.1 - 0.044 13.1 0.0 0.25 10.7 0.0 1.9 2 0 0 2 2 2 0 rRNA small subunit methyltransferase G Ubie_methyltran PF01209.18 EXF84479.1 - 0.056 12.8 0.0 0.29 10.4 0.0 2.0 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family CMAS PF02353.20 EXF84479.1 - 0.11 11.8 0.0 0.15 11.3 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase RrnaAD PF00398.20 EXF84479.1 - 0.15 11.1 0.0 0.21 10.6 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Glyco_transf_25 PF01755.17 EXF84480.1 - 1.1e-15 58.1 0.0 4.6e-11 43.0 0.0 2.1 2 0 0 2 2 2 2 Glycosyltransferase family 25 (LPS biosynthesis protein) PALP PF00291.25 EXF84481.1 - 9.1e-75 251.8 6.9 1.1e-74 251.5 6.9 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Glyco_tran_WecB PF03808.13 EXF84481.1 - 0.072 13.0 0.1 0.24 11.3 0.1 1.8 1 1 0 1 1 1 0 Glycosyl transferase WecB/TagA/CpsF family Apt1 PF10351.9 EXF84482.1 - 0.0013 17.7 4.6 0.0016 17.4 4.6 1.1 1 0 0 1 1 1 1 Golgi-body localisation protein domain EphA2_TM PF14575.6 EXF84482.1 - 0.21 12.5 0.0 7.5 7.5 0.0 2.3 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain PH_12 PF16457.5 EXF84482.1 - 0.93 10.0 9.1 1.5 9.3 9.1 1.2 1 0 0 1 1 1 0 Pleckstrin homology domain CPSF100_C PF13299.6 EXF84482.1 - 1.4 9.1 3.2 2.2 8.4 3.2 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF572 PF04502.13 EXF84482.1 - 1.8 8.1 5.0 2.6 7.6 5.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) SPX PF03105.19 EXF84482.1 - 3.9 7.3 14.5 0.28 11.0 9.6 1.5 2 0 0 2 2 2 0 SPX domain DUF4614 PF15391.6 EXF84482.1 - 5.8 6.9 21.6 10 6.1 21.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) RTA1 PF04479.13 EXF84483.1 - 2e-50 171.3 9.8 2.6e-50 170.9 9.8 1.1 1 0 0 1 1 1 1 RTA1 like protein Renin_r PF07850.14 EXF84483.1 - 0.13 12.8 4.7 0.24 12.0 0.2 2.5 2 0 0 2 2 2 0 Renin receptor-like protein DDRGK PF09756.9 EXF84483.1 - 0.38 10.3 8.0 0.52 9.9 8.0 1.1 1 0 0 1 1 1 0 DDRGK domain MIG-14_Wnt-bd PF06664.12 EXF84483.1 - 1.2 8.3 7.9 2.3 7.4 7.5 1.8 1 1 0 1 1 1 0 Wnt-binding factor required for Wnt secretion Ion_trans PF00520.31 EXF84484.1 - 4.3e-10 39.2 26.7 9.5e-10 38.1 26.7 1.5 1 0 0 1 1 1 1 Ion transport protein Abhydrolase_2 PF02230.16 EXF84485.1 - 2.2e-57 194.4 0.0 2.2e-34 119.2 0.0 2.1 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.8 EXF84485.1 - 5.3e-06 25.9 0.3 0.0066 15.7 0.0 3.1 2 1 1 3 3 3 2 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 EXF84485.1 - 0.0005 19.6 0.2 0.013 15.0 0.0 2.7 4 0 0 4 4 4 1 Prolyl oligopeptidase family FSH1 PF03959.13 EXF84485.1 - 0.032 13.9 0.0 0.27 10.9 0.0 2.2 1 1 0 1 1 1 0 Serine hydrolase (FSH1) DLH PF01738.18 EXF84485.1 - 0.046 13.3 0.0 0.082 12.4 0.0 1.4 1 1 0 1 1 1 0 Dienelactone hydrolase family Abhydrolase_3 PF07859.13 EXF84485.1 - 0.08 12.8 0.8 0.61 9.9 0.1 2.5 2 1 1 3 3 3 0 alpha/beta hydrolase fold DUF2974 PF11187.8 EXF84485.1 - 0.12 12.0 0.0 0.19 11.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Lipase_3 PF01764.25 EXF84485.1 - 0.15 11.9 0.0 0.36 10.7 0.0 1.6 2 0 0 2 2 2 0 Lipase (class 3) Cutinase PF01083.22 EXF84485.1 - 0.2 11.6 0.0 0.34 10.9 0.0 1.4 1 0 0 1 1 1 0 Cutinase IMD PF08397.11 EXF84486.1 - 0.0017 17.8 3.5 0.0022 17.4 0.4 2.0 2 0 0 2 2 2 1 IRSp53/MIM homology domain Rad21_Rec8_N PF04825.13 EXF84488.1 - 1.9e-31 108.5 0.0 3.1e-31 107.8 0.0 1.3 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein Rad21_Rec8 PF04824.16 EXF84488.1 - 1.3e-06 27.6 0.0 2.9e-06 26.5 0.0 1.5 1 0 0 1 1 1 1 Conserved region of Rad21 / Rec8 like protein GDI PF00996.18 EXF84489.1 - 5.7e-27 94.3 0.0 5.6e-15 54.8 0.0 2.1 1 1 1 2 2 2 2 GDP dissociation inhibitor Toprim_2 PF13155.6 EXF84490.1 - 0.042 14.3 0.1 0.29 11.6 0.0 2.1 1 1 1 2 2 2 0 Toprim-like RNase_PH PF01138.21 EXF84491.1 - 2.3e-15 57.3 0.0 6.7e-15 55.7 0.0 1.8 1 1 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 EXF84491.1 - 0.047 13.7 0.0 0.082 13.0 0.0 1.4 1 0 0 1 1 1 0 3' exoribonuclease family, domain 2 p450 PF00067.22 EXF84492.1 - 6e-13 48.4 0.0 8e-13 47.9 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 DUF998 PF06197.13 EXF84492.1 - 0.0096 15.5 0.0 0.017 14.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF998) K_channel_TID PF07941.11 EXF84492.1 - 0.99 9.9 7.1 4.8 7.7 5.4 2.3 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain Solute_trans_a PF03619.16 EXF84493.1 - 8.2e-60 202.6 11.3 9.7e-60 202.3 11.3 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha RhlB PF12300.8 EXF84493.1 - 1.4 9.0 5.9 2 8.5 5.9 1.3 1 0 0 1 1 1 0 ATP-dependent RNA helicase RhlB Pam16 PF03656.13 EXF84494.1 - 1.4e-33 115.6 0.1 1.7e-33 115.4 0.1 1.0 1 0 0 1 1 1 1 Pam16 cwf21 PF08312.12 EXF84494.1 - 0.33 11.2 2.6 0.57 10.4 2.6 1.3 1 0 0 1 1 1 0 cwf21 domain Beta_helix PF13229.6 EXF84495.1 - 1.4e-10 41.2 19.3 2.5e-09 37.2 17.4 2.5 2 1 0 2 2 2 1 Right handed beta helix region Chondroitinas_B PF14592.6 EXF84495.1 - 4.1e-07 29.2 0.3 1e-06 27.9 0.0 1.7 2 0 0 2 2 2 1 Chondroitinase B DUF1565 PF07602.11 EXF84495.1 - 0.0014 18.0 0.2 0.0014 18.0 0.2 2.4 2 1 0 2 2 2 1 Protein of unknown function (DUF1565) Yip1 PF04893.17 EXF84496.1 - 0.00027 20.7 16.8 0.0027 17.4 6.9 2.8 3 1 0 3 3 3 2 Yip1 domain RCC1 PF00415.18 EXF84497.1 - 1.7e-59 198.3 0.3 4.6e-10 40.0 0.0 7.5 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EXF84497.1 - 2.5e-35 119.6 27.3 1.5e-07 31.0 1.0 6.6 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat APH PF01636.23 EXF84499.1 - 0.032 14.2 0.0 0.068 13.1 0.0 1.5 1 1 0 1 1 1 0 Phosphotransferase enzyme family Choline_kinase PF01633.20 EXF84499.1 - 0.072 12.7 0.0 0.11 12.1 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase GMC_oxred_N PF00732.19 EXF84500.1 - 1.1e-57 195.7 0.0 1.6e-57 195.2 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EXF84500.1 - 8.1e-23 81.5 2.7 9.2e-22 78.1 1.4 3.1 2 1 0 2 2 2 1 GMC oxidoreductase FAD_binding_2 PF00890.24 EXF84500.1 - 0.00019 20.7 0.0 0.055 12.5 0.0 2.3 2 0 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 EXF84500.1 - 0.0033 17.6 0.0 0.0093 16.2 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EXF84500.1 - 0.0055 16.3 0.1 0.035 13.7 0.0 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EXF84500.1 - 0.012 14.9 0.0 0.71 9.1 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase EphA2_TM PF14575.6 EXF84500.1 - 0.015 16.1 0.0 0.043 14.7 0.0 1.8 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Thi4 PF01946.17 EXF84500.1 - 0.02 14.1 0.0 0.038 13.2 0.0 1.4 1 0 0 1 1 1 0 Thi4 family Pyr_redox_2 PF07992.14 EXF84500.1 - 0.032 13.5 0.1 0.28 10.4 0.1 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EXF84500.1 - 0.18 10.5 0.0 0.41 9.3 0.0 1.6 2 0 0 2 2 2 0 HI0933-like protein DUF3112 PF11309.8 EXF84500.1 - 6 6.2 5.8 1.1 8.7 0.5 2.0 1 1 0 2 2 2 0 Protein of unknown function (DUF3112) AA_permease_2 PF13520.6 EXF84501.1 - 1.8e-59 201.7 51.5 2.3e-59 201.4 51.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EXF84501.1 - 1.8e-27 96.1 39.2 2.5e-27 95.6 39.2 1.1 1 0 0 1 1 1 1 Amino acid permease TB2_DP1_HVA22 PF03134.19 EXF84502.1 - 5.4e-27 93.5 8.7 8.4e-27 92.9 8.7 1.3 1 0 0 1 1 1 1 TB2/DP1, HVA22 family Mgm101p PF06420.12 EXF84503.1 - 7.4e-85 282.7 0.0 1e-84 282.3 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial genome maintenance MGM101 Ndc1_Nup PF09531.10 EXF84503.1 - 0.00088 18.1 2.6 0.00088 18.1 2.6 1.0 1 0 0 1 1 1 1 Nucleoporin protein Ndc1-Nup Suf PF05843.14 EXF84503.1 - 0.13 12.2 8.5 0.19 11.7 8.5 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) TFIIA PF03153.13 EXF84503.1 - 0.83 9.6 13.5 1.1 9.2 13.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Med3 PF11593.8 EXF84503.1 - 8 5.5 30.0 11 5.1 30.0 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal CHCH PF06747.13 EXF84504.1 - 0.0056 16.8 8.6 0.01 15.9 8.6 1.5 1 0 0 1 1 1 1 CHCH domain Cmc1 PF08583.10 EXF84504.1 - 0.042 13.9 3.9 0.13 12.3 3.9 1.8 1 1 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like COX17 PF05051.13 EXF84504.1 - 0.044 14.1 2.3 0.066 13.6 2.3 1.2 1 0 0 1 1 1 0 Cytochrome C oxidase copper chaperone (COX17) GT-D PF08759.11 EXF84504.1 - 0.081 12.6 0.2 0.085 12.5 0.2 1.0 1 0 0 1 1 1 0 Glycosyltransferase GT-D fold CX9C PF16860.5 EXF84504.1 - 0.52 10.4 5.2 1.6 8.8 1.3 2.2 1 1 0 2 2 2 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, BPL_N PF09825.9 EXF84505.1 - 7.2e-142 472.9 0.0 8.8e-142 472.6 0.0 1.1 1 0 0 1 1 1 1 Biotin-protein ligase, N terminal BPL_LplA_LipB PF03099.19 EXF84505.1 - 6.5e-20 71.4 0.0 1.1e-19 70.7 0.0 1.4 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family BPL_C PF02237.17 EXF84505.1 - 0.035 14.0 0.0 0.068 13.1 0.0 1.5 1 0 0 1 1 1 0 Biotin protein ligase C terminal domain Asp PF00026.23 EXF84507.1 - 1.5e-75 254.5 13.3 1.8e-75 254.3 13.3 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EXF84507.1 - 7.8e-14 52.3 7.5 2.1e-07 31.3 0.1 2.7 2 1 1 3 3 3 2 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EXF84507.1 - 0.00032 21.3 3.8 0.037 14.7 1.3 3.0 2 1 0 2 2 2 2 Aspartyl protease BNR_4 PF15892.5 EXF84508.1 - 3.7e-79 265.9 5.2 4.6e-79 265.6 5.2 1.1 1 0 0 1 1 1 1 BNR repeat-containing family member BNR_2 PF13088.6 EXF84508.1 - 0.024 13.9 0.0 0.057 12.7 0.0 1.6 2 0 0 2 2 2 0 BNR repeat-like domain BNR PF02012.20 EXF84508.1 - 0.081 13.0 0.6 0.081 13.0 0.6 2.8 2 0 0 2 2 2 0 BNR/Asp-box repeat Sugar_tr PF00083.24 EXF84509.1 - 8.1e-120 400.7 21.0 9.3e-120 400.5 21.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF84509.1 - 2e-22 79.6 62.0 1.3e-20 73.7 30.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Fungal_trans PF04082.18 EXF84510.1 - 2.5e-12 46.4 0.0 4.5e-12 45.6 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF84510.1 - 4.8e-08 33.0 6.7 8.4e-08 32.2 6.7 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CGI-121 PF08617.10 EXF84511.1 - 9.3e-55 185.2 0.0 1.1e-54 185.0 0.0 1.0 1 0 0 1 1 1 1 Kinase binding protein CGI-121 Pro_dh PF01619.18 EXF84512.1 - 4.6e-69 233.2 0.0 5.3e-69 233.0 0.0 1.0 1 0 0 1 1 1 1 Proline dehydrogenase Tim17 PF02466.19 EXF84513.1 - 0.00062 20.1 4.2 0.001 19.4 2.6 2.0 1 1 1 2 2 2 1 Tim17/Tim22/Tim23/Pmp24 family TMEM208_SND2 PF05620.11 EXF84515.1 - 0.021 14.6 0.3 0.041 13.7 0.3 1.4 1 0 0 1 1 1 0 SRP-independent targeting protein 2/TMEM208 NIF PF03031.18 EXF84517.1 - 7.6e-38 129.7 0.0 1.1e-37 129.2 0.0 1.3 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase RNase_PH PF01138.21 EXF84518.1 - 2e-35 122.1 0.1 4.2e-35 121.1 0.1 1.6 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 Thioredoxin PF00085.20 EXF84519.1 - 7.7e-34 115.8 0.0 9.5e-27 93.0 0.0 2.4 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_6 PF13848.6 EXF84519.1 - 4.8e-12 46.2 0.0 0.00011 22.2 0.0 3.2 2 1 1 3 3 3 2 Thioredoxin-like domain OST3_OST6 PF04756.13 EXF84519.1 - 4.9e-07 29.4 0.0 6.3e-06 25.7 0.0 2.2 2 0 0 2 2 2 1 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 EXF84519.1 - 1.2e-06 29.0 0.3 0.024 15.1 0.1 2.8 1 1 1 2 2 2 2 Thioredoxin-like domain Thioredoxin_8 PF13905.6 EXF84519.1 - 0.0015 18.8 0.1 1.9 8.9 0.0 4.0 3 2 1 4 4 4 1 Thioredoxin-like CPSF100_C PF13299.6 EXF84519.1 - 0.0026 18.0 3.8 0.14 12.3 0.7 2.4 2 0 0 2 2 2 1 Cleavage and polyadenylation factor 2 C-terminal ERp29_N PF07912.13 EXF84519.1 - 0.012 15.8 0.0 0.93 9.7 0.0 2.4 1 1 1 2 2 2 0 ERp29, N-terminal domain Thioredoxin_3 PF13192.6 EXF84519.1 - 0.014 15.4 0.1 1.3 9.1 0.1 2.6 2 0 0 2 2 2 0 Thioredoxin domain TraF PF13728.6 EXF84519.1 - 0.016 15.0 0.0 0.016 15.0 0.0 3.9 4 0 0 4 4 2 0 F plasmid transfer operon protein Thioredoxin_7 PF13899.6 EXF84519.1 - 0.023 14.9 0.0 0.047 13.9 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin-like AhpC-TSA PF00578.21 EXF84519.1 - 0.044 13.7 0.1 0.69 9.8 0.0 2.4 2 0 0 2 2 2 0 AhpC/TSA family QSOX_Trx1 PF18108.1 EXF84519.1 - 0.049 13.8 0.0 0.13 12.5 0.0 1.6 1 0 0 1 1 1 0 QSOX Trx-like domain SWIRM-assoc_2 PF16496.5 EXF84519.1 - 0.08 11.8 4.7 0.15 10.9 4.7 1.4 1 0 0 1 1 1 0 SWIRM-associated domain at the N-terminal HyaE PF07449.11 EXF84519.1 - 0.081 12.9 0.0 5.6 7.0 0.0 3.1 2 1 0 2 2 2 0 Hydrogenase-1 expression protein HyaE Calsequestrin PF01216.17 EXF84519.1 - 0.09 11.8 0.1 0.5 9.3 0.0 2.1 1 1 0 2 2 2 0 Calsequestrin CCDC53 PF10152.9 EXF84519.1 - 0.15 12.5 6.9 0.94 9.9 1.2 2.4 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex RNA_pol_Rpc4 PF05132.14 EXF84519.1 - 9.8 6.6 12.8 0.76 10.2 3.7 2.5 2 0 0 2 2 2 0 RNA polymerase III RPC4 Vta1 PF04652.16 EXF84520.1 - 2.6e-55 186.4 3.5 3.9e-55 185.8 2.3 1.7 2 0 0 2 2 2 1 Vta1 like Vta1_C PF18097.1 EXF84520.1 - 1.6e-16 59.7 1.5 1.9e-16 59.5 0.1 1.9 2 0 0 2 2 2 1 Vta1 C-terminal domain HEAT_EZ PF13513.6 EXF84520.1 - 0.059 13.9 0.4 5.8 7.5 0.0 2.8 2 1 0 2 2 2 0 HEAT-like repeat DUF3731 PF12531.8 EXF84520.1 - 0.1 12.4 0.7 0.15 11.9 0.7 1.3 1 0 0 1 1 1 0 DNA-K related protein RBM39linker PF15519.6 EXF84520.1 - 0.12 13.5 0.2 0.12 13.5 0.2 2.8 3 1 0 3 3 3 0 linker between RRM2 and RRM3 domains in RBM39 protein adh_short_C2 PF13561.6 EXF84521.1 - 3.5e-58 196.9 0.1 4.6e-58 196.5 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF84521.1 - 1.7e-45 154.9 0.3 2.1e-45 154.6 0.3 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EXF84521.1 - 7.2e-10 39.1 0.4 1.9e-09 37.7 0.3 1.6 1 1 1 2 2 2 1 KR domain Epimerase PF01370.21 EXF84521.1 - 2e-05 24.2 0.1 3.3e-05 23.5 0.1 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF1776 PF08643.10 EXF84521.1 - 2.3e-05 23.9 0.0 3.3e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) Polysacc_synt_2 PF02719.15 EXF84521.1 - 0.0019 17.4 0.2 0.0025 17.0 0.2 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein ADH_zinc_N PF00107.26 EXF84521.1 - 0.29 11.1 1.8 0.78 9.7 1.8 1.9 1 1 0 1 1 1 0 Zinc-binding dehydrogenase ADH_N PF08240.12 EXF84522.1 - 5.2e-26 90.7 2.4 8.9e-26 89.9 2.4 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EXF84522.1 - 3.2e-17 62.7 0.0 5e-17 62.1 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EXF84522.1 - 0.0023 19.0 0.0 0.0049 17.9 0.0 1.6 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ELFV_dehydrog PF00208.21 EXF84522.1 - 0.15 11.7 0.3 0.24 11.1 0.3 1.2 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Vps54_N PF10475.9 EXF84523.1 - 0.55 9.5 6.9 0.048 12.9 0.9 2.1 2 0 0 2 2 2 0 Vacuolar-sorting protein 54, of GARP complex DUF1664 PF07889.12 EXF84523.1 - 0.69 10.0 13.4 0.4 10.7 3.1 3.0 2 2 0 2 2 2 0 Protein of unknown function (DUF1664) DUF4363 PF14276.6 EXF84523.1 - 1.2 9.3 4.9 1.8 8.7 0.1 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4363) MCPsignal PF00015.21 EXF84523.1 - 2.3 8.0 8.4 0.89 9.4 2.2 2.4 2 0 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain ZapB PF06005.12 EXF84523.1 - 2.7 8.5 18.2 1 9.9 0.6 3.9 3 0 0 3 3 3 0 Cell division protein ZapB BLOC1_2 PF10046.9 EXF84523.1 - 5.9 7.3 8.9 0.99 9.7 0.5 3.6 3 1 1 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 SKA2 PF16740.5 EXF84523.1 - 7.5 6.4 18.2 0.61 9.9 3.2 3.3 2 1 1 3 3 3 0 Spindle and kinetochore-associated protein 2 DUF2203 PF09969.9 EXF84523.1 - 9.9 6.9 8.2 17 6.1 0.9 3.1 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) Glyco_hydro_43 PF04616.14 EXF84525.1 - 2.9e-61 207.3 0.0 4.2e-61 206.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 GH43_C2 PF17851.1 EXF84525.1 - 3.1e-16 59.7 0.0 4.3e-16 59.3 0.0 1.2 1 0 0 1 1 1 1 Beta xylosidase C-terminal Concanavalin A-like domain NPH-II PF12011.8 EXF84525.1 - 0.11 12.4 0.1 0.18 11.7 0.1 1.3 1 0 0 1 1 1 0 RNA helicase NPH-II FAD_binding_3 PF01494.19 EXF84526.1 - 8.2e-24 84.5 0.1 6.2e-14 52.0 0.0 2.0 2 0 0 2 2 2 2 FAD binding domain Trp_halogenase PF04820.14 EXF84526.1 - 0.006 15.5 0.1 0.48 9.2 0.0 2.7 2 1 1 3 3 3 1 Tryptophan halogenase Amino_oxidase PF01593.24 EXF84526.1 - 0.0093 15.3 0.0 1.2 8.3 0.0 2.2 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase DAO PF01266.24 EXF84526.1 - 0.013 15.1 0.1 0.046 13.3 0.1 1.8 1 1 1 2 2 2 0 FAD dependent oxidoreductase Pyr_redox PF00070.27 EXF84526.1 - 0.013 16.0 3.3 0.018 15.6 0.1 2.6 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EXF84526.1 - 0.018 14.3 1.0 0.039 13.2 0.1 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EXF84526.1 - 0.047 12.7 0.1 0.74 8.8 0.0 2.2 2 0 0 2 2 2 0 Lycopene cyclase protein FAD_binding_3 PF01494.19 EXF84527.1 - 7.3e-43 147.2 0.0 8.8e-43 146.9 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain FAD_binding_2 PF00890.24 EXF84527.1 - 8.8e-05 21.8 0.0 0.00013 21.2 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 EXF84527.1 - 9e-05 22.2 1.2 0.00054 19.7 0.3 2.0 1 1 0 2 2 2 1 FAD dependent oxidoreductase HI0933_like PF03486.14 EXF84527.1 - 0.00011 21.0 0.2 0.00017 20.4 0.2 1.2 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_2 PF07992.14 EXF84527.1 - 0.0002 20.7 0.0 0.00039 19.8 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EXF84527.1 - 0.00047 20.3 0.1 0.0011 19.1 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 EXF84527.1 - 0.0011 19.5 0.1 0.011 16.3 0.1 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EXF84527.1 - 0.0032 16.6 0.0 0.0052 15.9 0.0 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_3 PF13738.6 EXF84527.1 - 0.004 16.5 0.0 0.0066 15.7 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EXF84527.1 - 0.015 14.6 0.1 0.038 13.2 0.2 1.6 2 0 0 2 2 2 0 Thi4 family UDPG_MGDP_dh_N PF03721.14 EXF84527.1 - 0.044 13.3 0.0 0.073 12.6 0.0 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain ApbA PF02558.16 EXF84527.1 - 0.062 13.0 0.1 0.1 12.2 0.1 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA 3HCDH_N PF02737.18 EXF84527.1 - 0.11 12.3 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FAD_oxidored PF12831.7 EXF84527.1 - 0.12 11.7 0.1 0.3 10.4 0.1 1.6 1 1 0 1 1 1 0 FAD dependent oxidoreductase NAD_binding_7 PF13241.6 EXF84527.1 - 0.15 12.5 0.1 0.62 10.5 0.0 2.1 3 0 0 3 3 3 0 Putative NAD(P)-binding GIDA PF01134.22 EXF84527.1 - 0.17 10.9 0.0 0.26 10.3 0.0 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A p450 PF00067.22 EXF84528.1 - 1.1e-44 153.0 0.0 1.7e-29 102.9 0.0 2.0 1 1 1 2 2 2 2 Cytochrome P450 p450 PF00067.22 EXF84529.1 - 2.5e-57 194.6 0.0 3e-57 194.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF1796 PF08795.10 EXF84529.1 - 0.032 14.2 0.0 0.05 13.6 0.0 1.2 1 0 0 1 1 1 0 Putative papain-like cysteine peptidase (DUF1796) Glyco_hydro_32N PF00251.20 EXF84530.1 - 2.2e-75 254.1 2.9 2.7e-75 253.8 2.9 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 N-terminal domain Glyco_hydro_32C PF08244.12 EXF84530.1 - 1.9e-05 24.7 0.3 3.4e-05 23.9 0.3 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 C terminal Aldo_ket_red PF00248.21 EXF84531.1 - 5.9e-43 147.2 0.0 6.6e-43 147.0 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family UDPGT PF00201.18 EXF84532.1 - 1.5e-05 24.1 0.0 2e-05 23.6 0.0 1.1 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase PsaM PF07465.13 EXF84532.1 - 0.81 9.5 5.4 1.8 8.3 5.4 1.5 1 0 0 1 1 1 0 Photosystem I protein M (PsaM) p450 PF00067.22 EXF84533.1 - 1.4e-66 225.2 0.0 1.7e-66 224.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Acyl_transf_1 PF00698.21 EXF84534.1 - 3.9e-25 89.0 0.5 4.9e-25 88.7 0.5 1.1 1 0 0 1 1 1 1 Acyl transferase domain Lysyl_oxidase PF01186.17 EXF84534.1 - 0.13 11.9 0.0 0.19 11.3 0.0 1.2 1 0 0 1 1 1 0 Lysyl oxidase FAM178 PF14816.6 EXF84535.1 - 0.072 12.0 0.5 0.086 11.8 0.5 1.1 1 0 0 1 1 1 0 Family of unknown function, FAM178 GBP_C PF02841.14 EXF84535.1 - 0.087 12.2 2.4 0.11 11.8 2.4 1.1 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain Zn_clus PF00172.18 EXF84535.1 - 0.13 12.4 8.7 0.22 11.7 8.7 1.3 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain APH PF01636.23 EXF84535.1 - 0.14 12.1 6.1 1 9.2 6.1 1.9 1 1 0 1 1 1 0 Phosphotransferase enzyme family muHD PF10291.9 EXF84536.1 - 3.1e-72 243.2 0.0 4.5e-72 242.7 0.0 1.3 1 0 0 1 1 1 1 Muniscin C-terminal mu homology domain FCH PF00611.23 EXF84536.1 - 6.9e-07 29.5 0.3 2.1e-06 27.9 0.0 2.0 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain LON_substr_bdg PF02190.16 EXF84536.1 - 0.078 12.8 0.3 0.15 11.9 0.3 1.5 1 0 0 1 1 1 0 ATP-dependent protease La (LON) substrate-binding domain DUF3584 PF12128.8 EXF84536.1 - 0.21 9.1 15.1 0.31 8.5 15.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Muted PF14942.6 EXF84536.1 - 1 9.7 8.8 0.74 10.1 5.6 2.3 2 0 0 2 2 2 0 Organelle biogenesis, Muted-like protein MAD PF05557.13 EXF84537.1 - 5.7e-65 219.9 59.7 1.5e-64 218.5 56.9 1.9 1 1 1 2 2 2 2 Mitotic checkpoint protein Golgin_A5 PF09787.9 EXF84537.1 - 0.0058 16.1 24.6 0.0058 16.1 24.6 4.7 3 2 1 4 4 4 2 Golgin subfamily A member 5 Tam41_Mmp37 PF09139.11 EXF84538.1 - 1.4e-126 422.4 0.0 1.7e-126 422.1 0.0 1.1 1 0 0 1 1 1 1 Phosphatidate cytidylyltransferase, mitochondrial FMO-like PF00743.19 EXF84540.1 - 4.8e-35 121.0 0.0 3.2e-19 68.8 0.1 3.0 3 0 0 3 3 3 3 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EXF84540.1 - 9.5e-16 57.9 0.1 2e-09 37.2 0.0 3.1 2 1 1 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EXF84540.1 - 1.7e-12 47.2 0.0 2.4e-11 43.4 0.0 2.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EXF84540.1 - 3.6e-09 36.8 0.0 1.2e-07 31.9 0.0 2.6 2 1 0 2 2 2 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 EXF84540.1 - 2.3e-07 31.0 0.0 5.2e-07 29.8 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 EXF84540.1 - 2.5e-07 30.2 0.1 5.5e-05 22.5 0.0 2.2 2 0 0 2 2 2 2 Thi4 family K_oxygenase PF13434.6 EXF84540.1 - 5.6e-07 29.0 0.0 0.0006 19.1 0.0 3.0 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.24 EXF84540.1 - 7.7e-07 29.0 0.0 0.013 15.2 0.0 3.1 3 0 0 3 3 3 2 FAD dependent oxidoreductase Pyr_redox PF00070.27 EXF84540.1 - 0.00054 20.5 0.1 0.032 14.8 0.0 3.0 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EXF84540.1 - 0.00061 19.2 0.0 0.0009 18.7 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Amino_oxidase PF01593.24 EXF84540.1 - 0.0044 16.4 0.0 0.0098 15.2 0.0 1.6 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase HI0933_like PF03486.14 EXF84540.1 - 0.0092 14.7 0.0 0.024 13.4 0.0 1.6 2 0 0 2 2 2 1 HI0933-like protein LpxD PF04613.14 EXF84540.1 - 0.041 13.7 0.1 0.57 10.0 0.0 2.5 2 0 0 2 2 2 0 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD Shikimate_DH PF01488.20 EXF84540.1 - 0.047 13.8 0.1 0.66 10.0 0.0 2.7 4 0 0 4 4 4 0 Shikimate / quinate 5-dehydrogenase Glu_dehyd_C PF16912.5 EXF84540.1 - 0.054 13.0 0.0 0.17 11.3 0.0 1.8 2 0 0 2 2 2 0 Glucose dehydrogenase C-terminus FAD_binding_3 PF01494.19 EXF84540.1 - 0.084 12.1 0.0 0.2 10.9 0.0 1.6 1 0 0 1 1 1 0 FAD binding domain GST_N_2 PF13409.6 EXF84541.1 - 1.3e-20 73.4 0.0 2.5e-20 72.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EXF84541.1 - 6.5e-18 64.5 0.0 1.6e-17 63.3 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EXF84541.1 - 2.6e-09 37.2 0.0 5e-09 36.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EXF84541.1 - 2e-05 24.9 0.0 0.1 13.0 0.0 2.5 2 0 0 2 2 2 2 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EXF84541.1 - 0.00051 20.2 0.0 0.00099 19.3 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 EXF84541.1 - 0.0046 16.7 0.0 0.0087 15.8 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Glutaredoxin PF00462.24 EXF84541.1 - 0.025 14.8 0.0 0.28 11.4 0.0 2.3 2 0 0 2 2 2 0 Glutaredoxin M20_dimer PF07687.14 EXF84542.1 - 6.8e-08 32.4 0.1 2.5e-07 30.6 0.1 2.0 1 1 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M20 PF01546.28 EXF84542.1 - 2.1e-07 30.9 2.9 4.9e-07 29.7 2.9 1.7 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 Het-C PF07217.11 EXF84542.1 - 0.098 11.2 0.0 0.15 10.5 0.0 1.2 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C Zn_clus PF00172.18 EXF84543.1 - 3.4e-05 23.9 13.5 7e-05 22.9 13.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Esterase_phd PF10503.9 EXF84545.1 - 5.9e-24 84.8 0.2 7.6e-24 84.4 0.2 1.1 1 0 0 1 1 1 1 Esterase PHB depolymerase Peptidase_S9 PF00326.21 EXF84545.1 - 1.5e-07 31.1 0.1 2.2e-07 30.6 0.1 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_3 PF07859.13 EXF84545.1 - 0.016 15.1 0.0 0.026 14.4 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Utp12 PF04003.12 EXF84546.1 - 2.9e-22 79.0 1.3 7.6e-22 77.7 0.1 2.0 2 0 0 2 2 2 1 Dip2/Utp12 Family SDA1 PF05285.12 EXF84546.1 - 0.39 10.1 37.7 0.41 10.0 20.5 2.2 2 0 0 2 2 2 0 SDA1 BSP_II PF05432.11 EXF84546.1 - 4.7 6.8 41.5 0.034 13.8 9.6 2.9 2 1 0 2 2 2 0 Bone sialoprotein II (BSP-II) Bromodomain PF00439.25 EXF84547.1 - 2.7e-34 117.1 0.2 2e-18 66.2 0.1 2.9 3 0 0 3 3 3 2 Bromodomain BET PF17035.5 EXF84547.1 - 5.8e-14 52.0 1.5 1.1e-13 51.1 1.5 1.5 1 0 0 1 1 1 1 Bromodomain extra-terminal - transcription regulation Pro_racemase PF05544.11 EXF84549.1 - 2.6e-56 191.0 3.1 7.3e-28 97.6 0.3 2.5 1 1 1 2 2 2 2 Proline racemase Abhydrolase_1 PF00561.20 EXF84550.1 - 1.3e-19 70.8 0.1 2.1e-19 70.2 0.1 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EXF84550.1 - 1.9e-14 54.8 0.0 2.2e-14 54.6 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EXF84550.1 - 2.5e-07 30.2 0.0 4.4e-07 29.4 0.0 1.4 2 0 0 2 2 2 1 Serine aminopeptidase, S33 EHN PF06441.12 EXF84550.1 - 0.038 14.3 0.3 0.08 13.3 0.3 1.5 1 0 0 1 1 1 0 Epoxide hydrolase N terminus AXE1 PF05448.12 EXF84550.1 - 0.09 11.4 0.0 0.13 10.9 0.0 1.2 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) Cytotoxic PF09000.10 EXF84552.1 - 0.064 13.6 0.1 0.22 11.9 0.1 1.8 1 0 0 1 1 1 0 Cytotoxic UCR_Fe-S_N PF10399.9 EXF84553.1 - 0.34 10.3 2.6 2 7.8 3.3 1.9 2 0 0 2 2 2 0 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal gag-asp_proteas PF13975.6 EXF84554.1 - 2.8e-11 43.8 0.0 2.4e-07 31.2 0.0 3.5 3 0 0 3 3 3 2 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 EXF84554.1 - 1.8e-10 41.3 0.1 1.8e-06 28.5 0.0 3.2 4 0 0 4 4 4 2 Aspartyl protease DnaJ PF00226.31 EXF84554.1 - 4.7e-06 26.6 0.1 0.0072 16.4 0.0 3.1 3 0 0 3 3 3 2 DnaJ domain Asp_protease PF09668.10 EXF84554.1 - 0.1 12.4 0.0 0.88 9.4 0.0 2.4 3 0 0 3 3 3 0 Aspartyl protease DUF1741 PF08427.10 EXF84555.1 - 5.6e-88 294.5 0.1 1.1e-87 293.6 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1741) Fe-S_biosyn PF01521.20 EXF84556.1 - 4.7e-18 65.4 0.0 6.6e-18 64.9 0.0 1.2 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis Mucin PF01456.17 EXF84556.1 - 0.022 14.8 15.0 0.028 14.4 15.0 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein MAP65_ASE1 PF03999.12 EXF84556.1 - 0.022 13.5 5.1 0.025 13.3 5.1 1.1 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) Ndc1_Nup PF09531.10 EXF84556.1 - 0.19 10.4 5.1 0.2 10.3 5.1 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup CDC27 PF09507.10 EXF84556.1 - 0.4 10.0 11.8 0.5 9.7 11.8 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 SSP160 PF06933.11 EXF84556.1 - 0.81 7.8 14.6 1.1 7.4 14.6 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 RAP1 PF07218.11 EXF84556.1 - 2.6 6.2 7.8 3.3 5.9 7.8 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) SOG2 PF10428.9 EXF84556.1 - 3.1 6.9 14.8 3.8 6.6 14.8 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein TFIIA PF03153.13 EXF84556.1 - 4 7.3 7.2 4.8 7.1 7.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Dicty_REP PF05086.12 EXF84556.1 - 4.8 5.0 4.7 5.6 4.8 4.7 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein FAM199X PF15814.5 EXF84556.1 - 6.3 5.8 7.8 8.7 5.3 7.8 1.1 1 0 0 1 1 1 0 Protein family FAM199X MgsA_C PF12002.8 EXF84557.1 - 1.2e-60 204.2 0.1 2e-60 203.6 0.1 1.3 1 0 0 1 1 1 1 MgsA AAA+ ATPase C terminal AAA_assoc_2 PF16193.5 EXF84557.1 - 4e-21 75.1 0.3 9e-21 74.0 0.3 1.6 1 0 0 1 1 1 1 AAA C-terminal domain AAA PF00004.29 EXF84557.1 - 2.8e-13 50.5 0.0 6.4e-13 49.3 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EXF84557.1 - 1.6e-08 34.4 0.0 3.7e-08 33.3 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain Sigma54_activat PF00158.26 EXF84557.1 - 3.6e-06 26.8 0.0 3.9e-05 23.4 0.0 2.2 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_16 PF13191.6 EXF84557.1 - 6.6e-06 26.6 0.8 0.0036 17.7 0.0 3.0 2 1 1 3 3 3 1 AAA ATPase domain AAA_5 PF07728.14 EXF84557.1 - 5e-05 23.3 0.1 0.0012 18.8 0.0 2.8 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 EXF84557.1 - 0.00023 20.6 0.1 0.14 11.6 0.0 2.2 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_22 PF13401.6 EXF84557.1 - 0.00033 20.9 0.4 0.0026 18.1 0.1 2.4 2 1 0 2 2 2 1 AAA domain AAA_14 PF13173.6 EXF84557.1 - 0.0033 17.5 0.0 0.0056 16.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain TIP49 PF06068.13 EXF84557.1 - 0.0041 16.4 0.0 0.007 15.6 0.0 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain DUF815 PF05673.13 EXF84557.1 - 0.0063 15.7 0.0 0.01 15.0 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_19 PF13245.6 EXF84557.1 - 0.016 15.5 0.1 0.19 12.0 0.2 2.4 1 1 1 2 2 2 0 AAA domain ResIII PF04851.15 EXF84557.1 - 0.023 14.7 0.2 0.91 9.5 0.0 2.2 1 1 1 2 2 2 0 Type III restriction enzyme, res subunit Sigma54_activ_2 PF14532.6 EXF84557.1 - 0.042 14.0 0.0 0.079 13.1 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain DNA_pol3_delta2 PF13177.6 EXF84557.1 - 0.043 13.6 0.0 3.3 7.5 0.0 2.4 1 1 1 2 2 2 0 DNA polymerase III, delta subunit SKI PF01202.22 EXF84557.1 - 0.045 13.9 0.1 0.082 13.0 0.1 1.4 1 0 0 1 1 1 0 Shikimate kinase AAA_3 PF07726.11 EXF84557.1 - 0.046 13.6 0.0 0.21 11.4 0.0 2.0 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) TRAF6_Z2 PF18048.1 EXF84557.1 - 0.079 13.1 0.2 0.13 12.4 0.2 1.4 1 0 0 1 1 1 0 TNF receptor-associated factor 6 zinc finger 2 AAA_24 PF13479.6 EXF84557.1 - 0.11 12.2 0.0 0.18 11.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain CPT PF07931.12 EXF84557.1 - 0.15 11.9 0.1 0.34 10.7 0.1 1.5 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein TniB PF05621.11 EXF84557.1 - 0.17 11.3 0.0 0.35 10.2 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein DUF2653 PF10850.8 EXF84559.1 - 0.13 12.5 0.0 0.25 11.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2653) Peptidase_M49 PF03571.15 EXF84560.1 - 3.5e-201 669.3 0.0 4.1e-201 669.1 0.0 1.0 1 0 0 1 1 1 1 Peptidase family M49 TPR_12 PF13424.6 EXF84562.1 - 8.9e-26 90.0 10.6 9.2e-10 38.7 0.1 6.5 5 1 1 6 6 6 3 Tetratricopeptide repeat NB-ARC PF00931.22 EXF84562.1 - 5.5e-22 78.2 0.0 8.7e-22 77.5 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain TPR_10 PF13374.6 EXF84562.1 - 5.8e-16 57.8 13.0 0.00053 19.8 0.6 7.0 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_MalT PF17874.1 EXF84562.1 - 4.7e-10 39.4 0.2 3.1e-09 36.6 0.0 2.4 2 1 0 2 2 2 1 MalT-like TPR region TPR_8 PF13181.6 EXF84562.1 - 4.8e-07 29.5 2.3 1.9 8.9 0.0 6.6 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_2 PF07719.17 EXF84562.1 - 1.6e-06 27.8 1.4 1.1 9.5 0.1 6.3 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_1 PF00515.28 EXF84562.1 - 5.8e-06 25.9 3.3 0.0062 16.3 0.1 4.9 5 0 0 5 5 5 1 Tetratricopeptide repeat AAA_16 PF13191.6 EXF84562.1 - 4.2e-05 24.0 0.0 0.00023 21.6 0.0 2.4 1 1 0 1 1 1 1 AAA ATPase domain TPR_7 PF13176.6 EXF84562.1 - 0.00017 21.4 6.7 0.2 11.8 0.2 5.1 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 EXF84562.1 - 0.00068 20.2 10.1 3.2 8.8 0.0 6.5 7 0 0 7 7 6 1 Tetratricopeptide repeat PPR PF01535.20 EXF84562.1 - 0.018 15.3 0.0 0.9 9.9 0.0 3.0 2 0 0 2 2 2 0 PPR repeat TPR_17 PF13431.6 EXF84562.1 - 0.021 15.2 0.0 15 6.2 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 EXF84562.1 - 0.056 14.0 4.9 3.4 8.3 0.0 4.4 3 2 1 4 4 4 0 Tetratricopeptide repeat Goodbye PF17109.5 EXF84562.1 - 0.063 13.7 0.1 0.25 11.8 0.0 2.2 2 0 0 2 2 1 0 fungal STAND N-terminal Goodbye domain TPR_6 PF13174.6 EXF84562.1 - 0.068 13.8 1.3 2.3e+02 2.8 0.2 5.6 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_4 PF07721.14 EXF84562.1 - 0.087 13.5 0.0 12 6.9 0.0 3.7 3 0 0 3 3 2 0 Tetratricopeptide repeat Peptidase_S8 PF00082.22 EXF84564.1 - 6.1e-24 84.8 0.0 1.6e-23 83.5 0.0 1.6 1 0 0 1 1 1 1 Subtilase family TPR_1 PF00515.28 EXF84564.1 - 1.2e-05 24.9 0.4 0.0002 21.0 0.1 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 EXF84564.1 - 4.4e-05 23.7 0.1 0.00017 21.8 0.1 2.1 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.17 EXF84564.1 - 0.0018 18.2 0.4 0.0018 18.2 0.4 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 EXF84564.1 - 0.0037 17.2 0.0 0.063 13.3 0.0 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 EXF84564.1 - 0.0055 16.8 0.4 0.029 14.6 0.1 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_10 PF13374.6 EXF84564.1 - 0.02 14.8 1.6 0.047 13.6 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 EXF84564.1 - 0.025 15.2 0.6 0.35 11.6 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EXF84564.1 - 0.037 14.3 0.7 0.77 10.0 0.1 3.0 3 1 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 DUF916 PF06030.12 EXF84567.1 - 0.11 12.5 0.0 0.17 12.0 0.0 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF916) COesterase PF00135.28 EXF84569.1 - 6.6e-88 295.8 0.0 8.3e-88 295.5 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EXF84569.1 - 0.0023 17.8 0.0 0.0063 16.4 0.0 1.7 1 0 0 1 1 1 1 alpha/beta hydrolase fold Fungal_trans PF04082.18 EXF84570.1 - 4.9e-14 52.0 0.3 9.6e-14 51.0 0.3 1.5 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF84570.1 - 3.9e-06 26.9 6.7 7.6e-06 26.0 6.7 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.16 EXF84571.1 - 1.7e-32 112.8 35.0 2.1e-32 112.5 35.0 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_4 PF06779.14 EXF84571.1 - 9.3e-07 28.5 19.4 1.4e-06 27.9 7.2 2.3 2 0 0 2 2 2 2 Uncharacterised MFS-type transporter YbfB DUF4509 PF14970.6 EXF84571.1 - 0.12 12.3 0.1 0.22 11.4 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4509) Aspzincin_M35 PF14521.6 EXF84572.1 - 0.0033 18.0 0.1 2.2 8.8 0.0 2.8 3 0 0 3 3 3 2 Lysine-specific metallo-endopeptidase FMN_dh PF01070.18 EXF84573.1 - 1.6e-128 428.6 0.1 1.9e-128 428.4 0.1 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase IMPDH PF00478.25 EXF84573.1 - 5.1e-11 42.2 1.2 1.1e-10 41.1 0.3 2.1 2 1 0 2 2 2 1 IMP dehydrogenase / GMP reductase domain NMO PF03060.15 EXF84573.1 - 3.1e-09 36.7 0.2 5.2e-09 36.0 0.2 1.3 1 0 0 1 1 1 1 Nitronate monooxygenase Glu_synthase PF01645.17 EXF84573.1 - 1.7e-06 27.5 0.6 3e-06 26.6 0.6 1.4 1 1 0 1 1 1 1 Conserved region in glutamate synthase ThiG PF05690.14 EXF84573.1 - 6e-06 25.8 1.3 0.0013 18.1 0.2 2.5 2 1 1 3 3 3 2 Thiazole biosynthesis protein ThiG DHO_dh PF01180.21 EXF84573.1 - 6.1e-05 22.4 0.4 0.00057 19.2 0.1 2.1 1 1 1 2 2 2 1 Dihydroorotate dehydrogenase His_biosynth PF00977.21 EXF84573.1 - 7.8e-05 22.2 0.7 0.0067 15.9 0.1 2.4 1 1 1 2 2 2 2 Histidine biosynthesis protein Dus PF01207.17 EXF84573.1 - 0.00069 18.8 0.1 0.0016 17.6 0.0 1.6 2 0 0 2 2 2 1 Dihydrouridine synthase (Dus) G3P_antiterm PF04309.12 EXF84573.1 - 0.0009 18.7 0.2 0.93 8.9 0.0 2.4 2 0 0 2 2 2 2 Glycerol-3-phosphate responsive antiterminator PcrB PF01884.17 EXF84573.1 - 0.003 17.1 0.2 5.6 6.3 0.0 3.6 4 0 0 4 4 4 1 PcrB family GST_C PF00043.25 EXF84574.1 - 2e-10 40.8 0.1 1.2e-09 38.2 0.0 2.1 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EXF84574.1 - 4.4e-08 33.3 0.0 8.5e-08 32.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EXF84574.1 - 6.7e-08 32.7 0.0 1.1e-07 32.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EXF84574.1 - 8.3e-07 28.9 0.0 1.7e-06 28.0 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EXF84574.1 - 5.7e-06 26.6 0.0 1.4e-05 25.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EXF84574.1 - 0.00028 21.0 0.0 0.00073 19.7 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Mistic PF11458.8 EXF84574.1 - 0.14 12.1 1.7 0.76 9.8 0.4 2.2 2 0 0 2 2 2 0 Membrane-integrating protein Mistic p450 PF00067.22 EXF84575.1 - 7e-37 127.2 0.0 1e-36 126.7 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 DUF1992 PF09350.10 EXF84576.1 - 1.2e-20 73.4 1.8 1.9e-20 72.8 0.4 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF1992) TRCF PF03461.15 EXF84576.1 - 0.034 14.5 0.0 0.077 13.4 0.0 1.6 1 0 0 1 1 1 0 TRCF domain adh_short PF00106.25 EXF84577.1 - 6.8e-36 123.6 0.0 8.1e-36 123.3 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF84577.1 - 6.6e-18 65.1 0.0 7.9e-18 64.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF84577.1 - 1.2e-06 28.5 0.0 2.1e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 KR domain Sacchrp_dh_NADP PF03435.18 EXF84577.1 - 0.0015 18.8 0.1 0.0028 17.9 0.1 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Epimerase PF01370.21 EXF84577.1 - 0.0051 16.3 0.1 0.0074 15.8 0.1 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EXF84577.1 - 0.0081 16.1 0.0 0.011 15.6 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding F420_oxidored PF03807.17 EXF84577.1 - 0.022 15.3 0.1 0.061 13.9 0.1 1.8 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent DUF1776 PF08643.10 EXF84577.1 - 0.065 12.6 0.1 0.093 12.1 0.1 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) NAD_binding_2 PF03446.15 EXF84577.1 - 0.088 13.0 0.0 0.18 12.0 0.0 1.5 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Shikimate_DH PF01488.20 EXF84577.1 - 0.11 12.5 0.0 0.16 12.0 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase 4HBT PF03061.22 EXF84578.1 - 1.6e-07 31.5 0.1 2.7e-07 30.8 0.1 1.3 1 0 0 1 1 1 1 Thioesterase superfamily Acyl-CoA_dh_1 PF00441.24 EXF84579.1 - 2.8e-28 99.0 0.6 4e-28 98.5 0.6 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 EXF84579.1 - 1.5e-25 89.2 0.1 2.5e-25 88.5 0.1 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 EXF84579.1 - 5.5e-23 81.8 0.0 1.7e-22 80.2 0.0 1.9 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 EXF84579.1 - 1.9e-05 24.9 0.3 3.4e-05 24.1 0.3 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain AMP-binding PF00501.28 EXF84580.1 - 0.0007 18.3 0.1 0.0048 15.6 0.0 2.0 2 0 0 2 2 2 1 AMP-binding enzyme FA_desaturase PF00487.24 EXF84581.1 - 5.6e-25 88.6 21.4 1.1e-24 87.7 21.4 1.4 1 0 0 1 1 1 1 Fatty acid desaturase DUF3474 PF11960.8 EXF84581.1 - 0.00017 21.8 0.0 0.00035 20.8 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3474) p450 PF00067.22 EXF84582.1 - 2e-63 214.8 0.0 2.7e-62 211.0 0.0 1.9 1 1 0 1 1 1 1 Cytochrome P450 Methyltransf_2 PF00891.18 EXF84583.1 - 5.9e-10 38.8 0.0 3.5e-09 36.3 0.0 2.0 1 1 0 1 1 1 1 O-methyltransferase domain Methyltransf_25 PF13649.6 EXF84583.1 - 0.00054 20.6 0.0 0.0013 19.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EXF84583.1 - 0.0011 18.6 0.0 0.0025 17.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase small domain Dimerisation PF08100.11 EXF84583.1 - 0.0021 18.1 0.1 0.0061 16.6 0.1 1.8 1 0 0 1 1 1 1 Dimerisation domain Methyltransf_23 PF13489.6 EXF84583.1 - 0.0027 17.6 0.0 0.0093 15.8 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF84583.1 - 0.011 15.5 0.0 0.027 14.3 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain MarR PF01047.22 EXF84583.1 - 0.056 13.4 0.1 0.55 10.2 0.0 2.3 2 0 0 2 2 2 0 MarR family FAD_binding_3 PF01494.19 EXF84584.1 - 3.7e-07 29.7 0.0 6.7e-07 28.9 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain zf-C2H2 PF00096.26 EXF84584.1 - 3.2e-06 27.3 8.9 0.0017 18.7 4.0 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EXF84584.1 - 7.9e-06 26.1 10.6 0.00011 22.4 0.8 3.0 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 EXF84584.1 - 1.6e-05 25.3 9.0 0.025 15.4 2.4 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EXF84584.1 - 0.00066 19.9 0.1 0.11 12.8 0.4 2.6 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.12 EXF84584.1 - 0.011 16.0 2.2 0.026 14.8 2.2 1.5 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.6 EXF84584.1 - 0.031 14.3 7.4 0.37 10.8 0.4 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger Pyr_redox_2 PF07992.14 EXF84584.1 - 0.043 13.1 0.0 0.077 12.2 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase SWI-SNF_Ssr4 PF08549.10 EXF84584.1 - 0.098 11.3 8.9 0.15 10.6 8.9 1.2 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) zf-C2HE PF16278.5 EXF84584.1 - 0.22 12.0 2.9 8.9 6.9 0.4 2.7 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger FYDLN_acid PF09538.10 EXF84584.1 - 2.1 9.0 7.7 1.9 9.2 2.8 3.1 1 1 1 2 2 2 0 Protein of unknown function (FYDLN_acid) zf-C2HC_2 PF13913.6 EXF84584.1 - 2.5 8.1 7.9 2 8.4 2.9 2.5 2 0 0 2 2 2 0 zinc-finger of a C2HC-type HMG_CoA_synt_C PF08540.10 EXF84585.1 - 2.1e-91 306.4 0.2 2.8e-91 306.0 0.2 1.1 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal HMG_CoA_synt_N PF01154.17 EXF84585.1 - 6.4e-80 267.1 0.1 9.2e-80 266.6 0.1 1.2 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal 2OG-FeII_Oxy_2 PF13532.6 EXF84586.1 - 7.3e-14 52.4 0.0 9.1e-14 52.1 0.0 1.2 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 EXF84586.1 - 0.00037 20.9 0.0 0.00062 20.2 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily zf-AD PF07776.15 EXF84589.1 - 0.041 14.1 1.2 0.11 12.7 1.2 1.7 1 0 0 1 1 1 0 Zinc-finger associated domain (zf-AD) Thi4 PF01946.17 EXF84591.1 - 1e-116 388.2 0.4 1.2e-116 388.0 0.4 1.1 1 0 0 1 1 1 1 Thi4 family DAO PF01266.24 EXF84591.1 - 7.7e-08 32.3 3.6 8.9e-07 28.8 2.2 2.1 1 1 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EXF84591.1 - 3.7e-05 23.9 0.2 8.7e-05 22.7 0.2 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 EXF84591.1 - 0.00013 21.2 1.2 0.00047 19.3 0.6 1.9 2 0 0 2 2 2 1 Lycopene cyclase protein Pyr_redox_2 PF07992.14 EXF84591.1 - 0.00036 19.9 0.4 0.00064 19.0 0.3 1.4 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EXF84591.1 - 0.00072 18.7 3.7 0.0085 15.2 1.4 2.3 2 1 0 2 2 2 1 FAD binding domain NAD_binding_9 PF13454.6 EXF84591.1 - 0.0017 18.4 1.6 0.0027 17.7 0.1 2.1 3 0 0 3 3 3 1 FAD-NAD(P)-binding FAD_binding_3 PF01494.19 EXF84591.1 - 0.011 15.0 0.0 0.017 14.4 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain FAD_oxidored PF12831.7 EXF84591.1 - 0.034 13.5 0.3 0.049 13.0 0.3 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EXF84591.1 - 0.051 12.8 0.0 0.075 12.3 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Zn_clus PF00172.18 EXF84592.1 - 2.1e-05 24.5 14.4 4.5e-05 23.5 14.4 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EXF84592.1 - 5e-05 22.3 0.3 7.2e-05 21.8 0.3 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain p450 PF00067.22 EXF84593.1 - 6.1e-36 124.2 0.0 1.1e-35 123.3 0.0 1.3 1 0 0 1 1 1 1 Cytochrome P450 Staph_opine_DH PF10100.9 EXF84593.1 - 0.24 10.0 0.0 0.33 9.5 0.0 1.1 1 0 0 1 1 1 0 Staphylopine dehydrogenase Rxt3 PF08642.10 EXF84594.1 - 1.3e-44 152.0 0.0 3.3e-44 150.7 0.0 1.7 1 0 0 1 1 1 1 Histone deacetylation protein Rxt3 LCCL PF03815.19 EXF84594.1 - 0.00033 20.7 0.0 0.0098 16.0 0.0 2.3 2 0 0 2 2 2 1 LCCL domain DUF1674 PF07896.12 EXF84595.1 - 5.2e-19 68.5 2.2 1.5e-18 66.9 2.2 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF1674) DUF3439 PF11921.8 EXF84595.1 - 0.033 14.2 5.0 0.046 13.7 5.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Mucin PF01456.17 EXF84595.1 - 0.14 12.1 14.7 0.2 11.6 14.7 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein SSP160 PF06933.11 EXF84595.1 - 0.52 8.4 13.6 0.63 8.2 13.6 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 MGC-24 PF05283.11 EXF84595.1 - 4.4 7.8 8.1 6.5 7.2 8.1 1.3 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin FSA_C PF10479.9 EXF84595.1 - 6.3 4.8 6.0 7.3 4.6 6.0 1.0 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus ATF7IP_BD PF16788.5 EXF84595.1 - 8.3 6.4 6.4 11 6.1 6.4 1.2 1 0 0 1 1 1 0 ATF-interacting protein binding domain Glyco_hydro_43 PF04616.14 EXF84597.1 - 1.8e-31 109.6 2.2 2.1e-31 109.3 2.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 Whib PF02467.16 EXF84600.1 - 0.22 12.1 5.6 6.2 7.5 2.4 3.2 2 1 1 3 3 3 0 Transcription factor WhiB PA_decarbox PF05870.11 EXF84602.1 - 1.5e-08 34.4 0.2 2.5e-08 33.7 0.2 1.3 1 0 0 1 1 1 1 Phenolic acid decarboxylase (PAD) DUF2855 PF11017.8 EXF84603.1 - 8.1e-99 331.6 0.0 9.4e-99 331.4 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2855) RMMBL PF07521.12 EXF84603.1 - 0.016 15.1 0.0 0.032 14.2 0.0 1.4 1 0 0 1 1 1 0 Zn-dependent metallo-hydrolase RNA specificity domain ADH_N PF08240.12 EXF84604.1 - 8.6e-25 86.7 7.4 1.6e-24 85.9 7.4 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EXF84604.1 - 9.7e-23 80.6 0.0 7.4e-22 77.7 0.0 2.3 3 0 0 3 3 3 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EXF84604.1 - 4.2e-05 24.6 0.0 7.3e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 EXF84604.1 - 0.00036 19.9 0.0 0.00072 18.9 0.0 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.19 EXF84604.1 - 0.0018 17.7 0.1 0.0031 16.9 0.1 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ApbA PF02558.16 EXF84604.1 - 0.037 13.7 0.0 0.061 13.0 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA PhyH PF05721.13 EXF84606.1 - 8.9e-05 22.8 0.0 0.00013 22.3 0.0 1.2 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) AAL_decarboxy PF03306.13 EXF84606.1 - 0.0028 17.0 0.0 0.0032 16.8 0.0 1.0 1 0 0 1 1 1 1 Alpha-acetolactate decarboxylase DUF4792 PF16040.5 EXF84606.1 - 0.083 12.8 0.0 0.18 11.7 0.0 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4792) PhyH PF05721.13 EXF84607.1 - 4.8e-15 56.4 0.0 5.4e-15 56.2 0.0 1.0 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) Acetyltransf_1 PF00583.25 EXF84608.1 - 0.00038 20.7 0.0 0.00049 20.3 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EXF84608.1 - 0.022 15.2 0.0 0.038 14.4 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EXF84608.1 - 0.041 13.8 0.0 0.065 13.2 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Fungal_trans_2 PF11951.8 EXF84609.1 - 8.8e-06 24.8 0.4 0.0018 17.2 0.0 2.1 2 0 0 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF84609.1 - 1.5e-05 25.0 7.7 4.7e-05 23.4 7.7 1.9 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Chloroa_b-bind PF00504.21 EXF84609.1 - 0.055 14.0 0.0 0.098 13.2 0.0 1.4 1 0 0 1 1 1 0 Chlorophyll A-B binding protein NUDIX PF00293.28 EXF84610.1 - 8.2e-16 58.2 0.0 9.3e-16 58.1 0.0 1.0 1 0 0 1 1 1 1 NUDIX domain NUDIX_2 PF13869.6 EXF84610.1 - 0.00035 20.2 0.0 0.00043 19.9 0.0 1.2 1 0 0 1 1 1 1 Nucleotide hydrolase DUF4916 PF16262.5 EXF84610.1 - 0.00052 19.5 0.0 0.00071 19.1 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4916) NUDIX_4 PF14815.6 EXF84610.1 - 0.0011 19.0 0.0 0.0046 16.9 0.0 1.9 1 1 0 1 1 1 1 NUDIX domain AAA_16 PF13191.6 EXF84611.1 - 1.3e-07 32.2 0.5 1.6e-06 28.6 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain NACHT PF05729.12 EXF84611.1 - 6.6e-07 29.4 0.0 1.7e-06 28.1 0.0 1.7 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 EXF84611.1 - 0.00011 22.5 0.2 0.0027 18.0 0.0 2.7 2 1 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 EXF84611.1 - 0.0065 16.8 0.1 0.046 14.1 0.0 2.3 2 0 0 2 2 2 1 RNA helicase ABC_tran PF00005.27 EXF84611.1 - 0.01 16.4 1.6 0.032 14.8 0.0 2.4 2 1 0 2 2 2 0 ABC transporter MMR_HSR1 PF01926.23 EXF84611.1 - 0.015 15.4 0.0 0.056 13.5 0.0 2.0 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_30 PF13604.6 EXF84611.1 - 0.019 14.7 0.0 0.041 13.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 EXF84611.1 - 0.024 15.2 5.2 0.62 10.5 0.0 3.3 3 0 0 3 3 3 0 AAA domain AAA_18 PF13238.6 EXF84611.1 - 0.042 14.4 0.3 0.17 12.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 EXF84611.1 - 0.051 14.0 0.0 0.23 11.9 0.0 2.2 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 EXF84611.1 - 0.063 12.8 0.0 0.35 10.4 0.0 2.2 2 0 0 2 2 2 0 AAA domain Ploopntkinase3 PF18751.1 EXF84611.1 - 0.081 12.8 0.0 0.23 11.4 0.0 1.7 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 AAA_33 PF13671.6 EXF84611.1 - 0.099 12.8 0.7 0.7 10.0 0.0 2.6 3 0 0 3 3 3 0 AAA domain AAA_29 PF13555.6 EXF84611.1 - 0.12 12.1 0.1 0.3 10.9 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Peptidase_S49_N PF08496.10 EXF84611.1 - 0.21 11.7 1.1 0.42 10.7 1.1 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal DUF2730 PF10805.8 EXF84611.1 - 1 9.5 4.2 6.5 6.9 1.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2730) KELK PF15796.5 EXF84611.1 - 1.1 9.7 7.1 2.7 8.5 5.4 2.5 2 1 0 2 2 2 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase Peptidase_M54 PF07998.11 EXF84612.1 - 9.3e-09 35.6 0.0 2.1e-08 34.4 0.0 1.5 2 0 0 2 2 2 1 Peptidase family M54 Peptidase_M10 PF00413.24 EXF84612.1 - 0.009 15.9 0.0 0.015 15.2 0.0 1.3 1 0 0 1 1 1 1 Matrixin Reprolysin_3 PF13582.6 EXF84612.1 - 0.11 13.0 0.0 0.22 12.0 0.0 1.5 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Serglycin PF04360.12 EXF84612.1 - 0.4 10.6 3.2 0.72 9.8 3.2 1.3 1 0 0 1 1 1 0 Serglycin DUF5549 PF17703.1 EXF84612.1 - 3.2 7.4 9.0 0.81 9.3 2.7 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5549) HET PF06985.11 EXF84618.1 - 1.3e-14 54.7 0.0 2.7e-14 53.8 0.0 1.5 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Ifi-6-16 PF06140.13 EXF84621.1 - 0.011 15.6 6.7 0.011 15.6 6.7 2.6 2 1 1 3 3 3 0 Interferon-induced 6-16 family BTB PF00651.31 EXF84622.1 - 2.1e-10 40.8 0.3 7.8e-10 39.0 0.3 2.0 1 1 0 1 1 1 1 BTB/POZ domain SET PF00856.28 EXF84623.1 - 8.7e-10 39.2 0.0 1.4e-09 38.5 0.0 1.4 1 0 0 1 1 1 1 SET domain DUF3723 PF12520.8 EXF84624.1 - 4.6e-08 32.2 0.0 5.6e-08 31.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3723) DUF3723 PF12520.8 EXF84625.1 - 6.9e-58 196.6 0.0 9.8e-57 192.8 0.0 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF3723) FIN1 PF17300.2 EXF84625.1 - 0.047 13.2 0.2 0.17 11.3 0.2 1.9 1 1 0 1 1 1 0 Filaments in between nuclei protein-1 DUF3723 PF12520.8 EXF84626.1 - 9.9e-72 242.2 4.0 3.5e-69 233.8 4.0 2.9 1 1 0 1 1 1 1 Protein of unknown function (DUF3723) DUF2205 PF10224.9 EXF84627.1 - 3e-35 120.0 0.3 5.3e-35 119.2 0.3 1.4 1 0 0 1 1 1 1 Short coiled-coil protein AAA_32 PF13654.6 EXF84627.1 - 0.032 13.0 0.0 0.039 12.8 0.0 1.1 1 0 0 1 1 1 0 AAA domain Nramp PF01566.18 EXF84628.1 - 8e-92 308.0 13.0 2e-91 306.6 13.0 1.6 1 1 0 1 1 1 1 Natural resistance-associated macrophage protein Ribonuc_L-PSP PF01042.21 EXF84628.1 - 2.2e-20 72.9 0.0 4.5e-20 71.9 0.0 1.5 1 0 0 1 1 1 1 Endoribonuclease L-PSP Fungal_trans PF04082.18 EXF84630.1 - 9e-21 74.1 0.1 1.4e-20 73.5 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF84630.1 - 9.4e-07 28.9 11.6 2.2e-06 27.7 11.6 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EXF84630.1 - 0.0055 15.6 0.0 0.024 13.5 0.0 2.0 2 0 0 2 2 2 1 Fungal specific transcription factor domain Bac_rhodopsin PF01036.18 EXF84631.1 - 8.1e-61 205.4 11.9 1.1e-60 205.1 11.9 1.0 1 0 0 1 1 1 1 Bacteriorhodopsin-like protein FtsX PF02687.21 EXF84631.1 - 0.11 12.9 0.1 0.11 12.9 0.1 2.6 1 1 2 3 3 3 0 FtsX-like permease family RPE65 PF03055.15 EXF84632.1 - 1.2e-124 417.1 0.0 1.3e-124 416.9 0.0 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein E1-E2_ATPase PF00122.20 EXF84633.1 - 9.2e-38 129.6 20.4 7.6e-37 126.6 7.2 3.8 3 1 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 EXF84633.1 - 3.8e-27 95.2 5.1 3.8e-27 95.2 5.1 2.2 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 EXF84633.1 - 1.3e-17 64.9 1.2 7.7e-16 59.0 1.2 3.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EXF84633.1 - 4.9e-14 51.8 0.0 1.1e-13 50.7 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 EXF84633.1 - 3.8e-13 49.3 0.0 7.2e-13 48.4 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EXF84633.1 - 4.7e-06 26.5 1.5 6.2e-05 22.9 0.5 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase IncE PF17627.2 EXF84633.1 - 0.18 11.8 3.1 0.25 11.4 0.9 2.4 2 0 0 2 2 2 0 Inclusion membrane protein E Sulfotransfer_4 PF17784.1 EXF84634.1 - 5.8e-56 189.7 0.0 6.9e-56 189.5 0.0 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 EXF84634.1 - 0.0021 18.5 1.0 1.1 9.6 0.1 2.6 1 1 0 2 2 2 2 Sulfotransferase family DUF866 PF05907.13 EXF84634.1 - 0.1 12.5 0.1 0.14 12.0 0.1 1.1 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF866) HsbA PF12296.8 EXF84635.1 - 2.3e-27 95.8 17.9 2.3e-27 95.8 17.9 1.8 2 0 0 2 2 2 1 Hydrophobic surface binding protein A Podoplanin PF05808.11 EXF84635.1 - 0.0016 18.6 1.6 0.0022 18.1 1.6 1.2 1 0 0 1 1 1 1 Podoplanin T3SS_TC PF06511.11 EXF84635.1 - 0.016 14.6 3.2 0.021 14.2 3.2 1.2 1 0 0 1 1 1 0 Type III secretion systems tip complex components Sec8_exocyst PF04048.14 EXF84635.1 - 0.02 14.8 2.1 0.026 14.4 1.3 1.5 2 0 0 2 2 2 0 Sec8 exocyst complex component specific domain NPV_P10 PF05531.12 EXF84635.1 - 0.045 14.2 11.7 0.64 10.5 1.9 2.9 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein Laminin_II PF06009.12 EXF84635.1 - 0.06 13.4 4.0 0.34 10.9 0.7 2.3 1 1 1 2 2 2 0 Laminin Domain II ApoLp-III PF07464.11 EXF84635.1 - 0.47 10.5 7.4 0.74 9.9 3.6 2.6 1 1 1 2 2 2 0 Apolipophorin-III precursor (apoLp-III) TrbC PF04956.13 EXF84635.1 - 7.4 6.9 10.9 0.21 11.8 1.1 3.1 2 2 1 3 3 3 0 TrbC/VIRB2 family HET PF06985.11 EXF84636.1 - 1.4e-10 41.7 4.0 9.1e-08 32.6 0.6 2.3 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) SNF2_N PF00176.23 EXF84638.1 - 4e-66 223.1 0.3 6.6e-66 222.4 0.3 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EXF84638.1 - 7.2e-19 68.2 0.0 4.1e-18 65.7 0.1 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EXF84638.1 - 3e-09 37.1 0.0 7.3e-09 35.9 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HSA PF07529.13 EXF84638.1 - 0.0018 18.6 6.9 0.0018 18.6 6.9 2.5 2 0 0 2 2 2 1 HSA HDA2-3 PF11496.8 EXF84638.1 - 0.0062 15.7 0.2 0.99 8.5 0.0 2.6 2 1 0 2 2 2 2 Class II histone deacetylase complex subunits 2 and 3 NDUF_B8 PF05821.11 EXF84639.1 - 4.6e-07 29.9 2.2 7.2e-07 29.2 2.1 1.3 1 1 0 1 1 1 1 NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8) Glyco_hydro_1 PF00232.18 EXF84641.1 - 2.1e-72 244.0 0.0 9.5e-72 241.8 0.0 1.8 1 1 0 1 1 1 1 Glycosyl hydrolase family 1 Cellulase PF00150.18 EXF84641.1 - 0.01 15.3 0.2 0.037 13.4 0.0 1.8 2 0 0 2 2 2 0 Cellulase (glycosyl hydrolase family 5) AMP-binding PF00501.28 EXF84642.1 - 1.8e-20 73.0 0.0 3.1e-20 72.2 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme ADH_N PF08240.12 EXF84643.1 - 0.00012 21.9 0.0 0.0016 18.3 0.0 2.2 1 1 1 2 2 2 2 Alcohol dehydrogenase GroES-like domain MFS_1 PF07690.16 EXF84644.1 - 2e-35 122.4 68.2 7.1e-35 120.6 65.9 3.0 2 1 0 2 2 2 1 Major Facilitator Superfamily ASFV_L11L PF05293.11 EXF84644.1 - 0.032 14.6 1.3 0.16 12.4 1.3 2.2 1 0 0 1 1 1 0 African swine fever virus (ASFV) L11L protein MLTD_N PF06474.12 EXF84644.1 - 6.3 7.1 6.1 0.57 10.4 0.5 2.2 2 0 0 2 2 2 0 MltD lipid attachment motif F-box-like PF12937.7 EXF84645.1 - 5.5e-05 23.0 0.5 0.00013 21.7 0.5 1.7 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.7 EXF84645.1 - 0.0064 16.9 4.4 0.11 13.0 0.2 4.3 5 0 0 5 5 5 1 Leucine Rich repeats (2 copies) p450 PF00067.22 EXF84646.1 - 8.2e-49 166.6 0.0 1.3e-48 165.9 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 Acyl_transf_1 PF00698.21 EXF84646.1 - 0.053 13.0 0.1 0.13 11.8 0.1 1.6 2 0 0 2 2 2 0 Acyl transferase domain Trehalase_Ca-bi PF07492.11 EXF84646.1 - 0.56 10.0 1.8 0.96 9.2 1.8 1.3 1 0 0 1 1 1 0 Neutral trehalase Ca2+ binding domain Amino_oxidase PF01593.24 EXF84647.1 - 2.2e-14 53.6 0.1 1.3e-13 51.0 0.1 2.1 2 1 0 2 2 2 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EXF84647.1 - 2.3e-14 53.3 0.1 5.9e-14 52.1 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 EXF84647.1 - 8.3e-09 35.3 0.0 8.3e-07 28.7 0.1 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EXF84647.1 - 1.5e-06 27.6 0.3 2.2e-06 27.0 0.3 1.2 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 EXF84647.1 - 1.4e-05 24.9 0.2 8.5e-05 22.3 0.2 2.3 1 1 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 EXF84647.1 - 2e-05 23.5 0.3 3.6e-05 22.7 0.1 1.4 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox PF00070.27 EXF84647.1 - 3.1e-05 24.5 0.2 0.0013 19.3 0.1 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EXF84647.1 - 0.00013 21.4 0.0 0.00025 20.4 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EXF84647.1 - 0.012 14.9 0.0 0.02 14.2 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EXF84647.1 - 0.013 14.7 0.0 0.032 13.5 0.0 1.5 1 0 0 1 1 1 0 Thi4 family FAD_binding_3 PF01494.19 EXF84647.1 - 0.022 14.0 0.2 0.037 13.3 0.2 1.3 1 0 0 1 1 1 0 FAD binding domain DUF4945 PF16303.5 EXF84647.1 - 0.03 14.3 0.0 0.12 12.3 0.0 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4945) ApbA PF02558.16 EXF84647.1 - 0.03 13.9 0.0 0.048 13.3 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA GIDA PF01134.22 EXF84647.1 - 0.12 11.5 0.2 0.17 10.9 0.2 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A NAD_binding_7 PF13241.6 EXF84647.1 - 0.15 12.5 0.0 0.43 11.1 0.0 1.7 1 0 0 1 1 1 0 Putative NAD(P)-binding MFS_1 PF07690.16 EXF84648.1 - 6.4e-25 87.8 30.0 6.4e-25 87.8 30.0 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF84648.1 - 4e-05 22.7 23.5 0.00058 18.8 23.5 2.6 1 1 0 1 1 1 1 Sugar (and other) transporter IBR PF01485.21 EXF84649.1 - 7.4e-12 45.3 34.5 1.5e-07 31.5 8.0 3.8 3 1 0 3 3 3 2 IBR domain, a half RING-finger domain zf-RING_2 PF13639.6 EXF84649.1 - 0.0026 18.1 10.2 0.0026 18.1 10.2 3.5 2 1 1 3 3 3 1 Ring finger domain zf-RING_UBOX PF13445.6 EXF84649.1 - 0.003 17.6 10.0 0.003 17.6 10.0 2.5 3 0 0 3 3 3 1 RING-type zinc-finger Pyr_excise PF03013.14 EXF84649.1 - 0.21 11.6 10.0 0.18 11.7 0.8 3.2 3 2 1 4 4 4 0 Pyrimidine dimer DNA glycosylase zf-RING_11 PF17123.5 EXF84649.1 - 0.3 10.9 7.3 0.92 9.3 7.3 1.9 1 0 0 1 1 1 0 RING-like zinc finger Phage_int_SAM_2 PF12834.7 EXF84649.1 - 3.8 8.3 7.7 6.3 7.6 1.0 2.6 2 0 0 2 2 2 0 Phage integrase, N-terminal CorA PF01544.18 EXF84650.1 - 1.5e-13 50.8 0.1 2.3e-13 50.1 0.1 1.2 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein DDE_Tnp_ISL3 PF01610.17 EXF84650.1 - 0.041 13.6 0.1 0.084 12.6 0.1 1.5 1 0 0 1 1 1 0 Transposase IMUP PF15761.5 EXF84650.1 - 0.066 13.9 2.5 0.16 12.7 2.5 1.6 1 0 0 1 1 1 0 Immortalisation up-regulated protein Ribosomal_L17 PF01196.19 EXF84650.1 - 0.14 13.0 0.4 1.3 10.0 0.1 2.3 2 0 0 2 2 2 0 Ribosomal protein L17 zf-C2H2 PF00096.26 EXF84653.1 - 5e-11 42.4 11.0 5.9e-05 23.3 0.7 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EXF84653.1 - 7.7e-09 35.6 8.8 0.0012 19.5 0.6 2.9 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EXF84653.1 - 4e-08 33.3 11.7 2e-06 27.9 1.2 2.9 3 0 0 3 3 3 2 Zinc-finger double domain BolA PF01722.18 EXF84653.1 - 0.0017 18.6 0.1 2.6 8.4 0.0 2.3 1 1 1 2 2 2 2 BolA-like protein zf-C2H2_jaz PF12171.8 EXF84653.1 - 0.004 17.4 3.5 0.14 12.5 0.1 2.4 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.6 EXF84653.1 - 0.0058 16.4 8.4 0.65 9.8 0.3 2.6 2 0 0 2 2 2 2 C2H2-type zinc-finger domain zf-C2H2_6 PF13912.6 EXF84653.1 - 0.028 14.4 10.9 0.21 11.6 0.2 3.1 3 0 0 3 3 3 0 C2H2-type zinc finger C5HCH PF17982.1 EXF84653.1 - 0.13 12.5 5.3 0.91 9.7 0.6 2.5 2 0 0 2 2 2 0 NSD Cys-His rich domain zf-met PF12874.7 EXF84653.1 - 0.4 11.1 3.9 0.53 10.7 0.1 2.7 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2HE PF16278.5 EXF84653.1 - 1.2 9.6 8.5 2 8.9 1.6 2.4 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-AN1 PF01428.16 EXF84653.1 - 3.9 7.7 8.8 10 6.4 1.5 2.4 1 1 1 2 2 2 0 AN1-like Zinc finger Fungal_trans_2 PF11951.8 EXF84655.1 - 1.7e-21 76.5 0.1 2e-21 76.3 0.1 1.0 1 0 0 1 1 1 1 Fungal specific transcription factor domain ATPgrasp_N PF18130.1 EXF84656.1 - 1.5e-17 63.9 0.0 3.2e-17 62.8 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp N-terminal domain ATP-grasp_4 PF13535.6 EXF84656.1 - 8.7e-10 38.4 0.0 3.2e-09 36.6 0.0 1.9 1 1 0 1 1 1 1 ATP-grasp domain CPSase_L_D2 PF02786.17 EXF84656.1 - 0.0029 17.1 0.0 0.0054 16.3 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Dala_Dala_lig_C PF07478.13 EXF84656.1 - 0.0041 16.7 0.0 0.0091 15.6 0.0 1.5 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp_3 PF02655.14 EXF84656.1 - 0.011 15.8 0.0 0.28 11.2 0.0 2.3 2 0 0 2 2 2 0 ATP-grasp domain GSH-S_ATP PF02955.16 EXF84656.1 - 0.025 14.0 0.0 0.042 13.2 0.0 1.3 1 0 0 1 1 1 0 Prokaryotic glutathione synthetase, ATP-grasp domain p450 PF00067.22 EXF84657.1 - 3.1e-37 128.4 0.0 4.1e-37 128.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Aminotran_3 PF00202.21 EXF84658.1 - 1.5e-82 277.5 0.0 1.9e-82 277.1 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 EXF84658.1 - 0.041 13.1 0.1 0.12 11.6 0.0 1.7 2 0 0 2 2 2 0 Aminotransferase class I and II Ank_2 PF12796.7 EXF84659.1 - 7.4e-20 71.3 1.6 1.7e-15 57.3 0.6 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EXF84659.1 - 1.3e-17 63.9 1.6 1.7e-08 34.9 0.2 3.2 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EXF84659.1 - 8.3e-16 56.5 1.2 0.00041 20.6 0.0 3.7 4 0 0 4 4 4 3 Ankyrin repeat Ank PF00023.30 EXF84659.1 - 2.1e-14 53.2 3.0 0.00034 20.9 0.1 3.5 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.6 EXF84659.1 - 1.1e-10 41.5 2.8 5.8e-05 23.3 0.1 3.7 2 1 2 4 4 4 3 Ankyrin repeats (many copies) MFS_1 PF07690.16 EXF84660.1 - 2e-33 115.8 53.4 1.6e-23 83.2 31.5 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily adh_short PF00106.25 EXF84660.1 - 1.6e-25 89.7 0.1 2.6e-25 89.0 0.1 1.4 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF84660.1 - 1.6e-19 70.4 0.2 2.6e-19 69.7 0.2 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF84660.1 - 2.9e-10 40.3 0.0 5.2e-10 39.5 0.0 1.4 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EXF84660.1 - 3.4e-05 23.4 0.0 6.6e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EXF84660.1 - 0.00088 19.2 0.1 0.0014 18.6 0.1 1.3 1 0 0 1 1 1 1 NAD(P)H-binding GFO_IDH_MocA PF01408.22 EXF84661.1 - 1.6e-05 25.7 0.0 4.5e-05 24.3 0.0 1.7 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold NADH_B2 PF14813.6 EXF84661.1 - 0.085 12.7 0.2 0.2 11.5 0.2 1.6 1 0 0 1 1 1 0 NADH dehydrogenase 1 beta subcomplex subunit 2 adh_short PF00106.25 EXF84663.1 - 3.1e-21 75.7 4.7 1.3e-17 64.0 0.1 2.0 1 1 1 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EXF84663.1 - 3.4e-18 66.1 2.6 4e-15 56.0 0.0 2.0 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF84663.1 - 2.2e-08 34.3 0.3 3.9e-08 33.4 0.3 1.4 1 1 0 1 1 1 1 KR domain 3HCDH_N PF02737.18 EXF84663.1 - 0.0073 16.2 0.0 0.011 15.7 0.0 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Polysacc_synt_2 PF02719.15 EXF84663.1 - 0.041 13.0 0.1 0.043 13.0 0.1 1.1 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein ChuX_HutX PF06228.13 EXF84663.1 - 0.057 13.2 0.0 0.097 12.5 0.0 1.3 1 1 0 1 1 1 0 Haem utilisation ChuX/HutX MTS PF05175.14 EXF84663.1 - 0.091 12.3 0.0 0.11 12.0 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain Ldh_1_N PF00056.23 EXF84663.1 - 0.32 11.1 2.8 0.97 9.5 1.2 2.3 2 1 1 3 3 3 0 lactate/malate dehydrogenase, NAD binding domain MFS_1 PF07690.16 EXF84664.1 - 8.8e-28 97.2 68.8 3e-26 92.2 35.8 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily APOC4 PF15119.6 EXF84664.1 - 0.001 19.3 0.0 0.0019 18.4 0.0 1.4 1 0 0 1 1 1 1 Apolipoprotein C4 DUF5345 PF17280.2 EXF84664.1 - 0.44 10.5 4.9 4.6 7.3 2.9 2.7 2 0 0 2 2 2 0 Family of unknown function (DUF5345) Zn_clus PF00172.18 EXF84665.1 - 6e-08 32.7 11.8 1.1e-07 31.9 11.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EXF84665.1 - 1.1e-07 31.2 0.0 2.3e-07 30.1 0.0 1.5 2 0 0 2 2 2 1 Fungal specific transcription factor domain Acetate_kinase PF00871.17 EXF84666.1 - 1e-90 304.3 0.0 1.3e-90 304.0 0.0 1.1 1 0 0 1 1 1 1 Acetokinase family Sugar_tr PF00083.24 EXF84667.1 - 1.5e-32 113.1 22.1 8.7e-19 67.7 9.4 2.5 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 EXF84667.1 - 1.4e-22 80.1 24.8 1.9e-16 60.0 14.1 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily Fungal_trans PF04082.18 EXF84668.1 - 6.7e-20 71.2 0.0 1.3e-19 70.3 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain GST_N_3 PF13417.6 EXF84668.1 - 3.7e-15 56.1 0.0 8.3e-15 55.0 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EXF84668.1 - 4.2e-10 39.8 0.0 1e-09 38.5 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Zn_clus PF00172.18 EXF84668.1 - 9.7e-09 35.2 8.4 2.1e-08 34.1 8.4 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain GST_N PF02798.20 EXF84668.1 - 6.5e-08 32.8 0.0 1.5e-07 31.6 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EXF84668.1 - 3.3e-05 23.8 0.1 0.00011 22.1 0.2 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_5 PF16865.5 EXF84668.1 - 5.4e-05 23.7 0.0 0.00013 22.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EXF84668.1 - 0.16 12.2 0.0 0.53 10.5 0.0 1.8 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain WD40 PF00400.32 EXF84669.1 - 1.3e-20 73.3 6.6 5.2e-06 27.1 0.3 5.7 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EXF84669.1 - 2.3e-14 53.4 0.0 0.017 15.4 0.0 5.2 2 2 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EXF84669.1 - 0.0013 17.5 0.2 0.09 11.4 0.0 2.3 1 1 1 2 2 2 2 Nucleoporin Nup120/160 eIF2A PF08662.11 EXF84669.1 - 0.019 14.9 0.1 0.68 9.8 0.0 2.9 2 2 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 EXF84669.1 - 0.024 13.6 0.1 5.5 5.8 0.0 2.7 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF1513 PF07433.11 EXF84669.1 - 0.048 12.7 0.0 0.58 9.2 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1513) RIC1 PF07064.13 EXF84671.1 - 1.2e-96 323.0 0.1 1.7e-96 322.5 0.1 1.2 1 0 0 1 1 1 1 RIC1 ANAPC4_WD40 PF12894.7 EXF84671.1 - 0.027 14.8 0.0 2.1 8.7 0.0 3.7 3 2 1 5 5 5 0 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EXF84671.1 - 0.073 14.0 0.6 42 5.2 0.0 4.3 4 0 0 4 4 4 0 WD domain, G-beta repeat CK_II_beta PF01214.18 EXF84672.1 - 8.1e-77 257.1 0.1 9.9e-77 256.9 0.1 1.1 1 0 0 1 1 1 1 Casein kinase II regulatory subunit PAP2 PF01569.21 EXF84673.1 - 1.9e-22 79.5 1.2 1.9e-22 79.5 1.2 2.3 2 1 0 2 2 2 1 PAP2 superfamily DUF4386 PF14329.6 EXF84673.1 - 0.023 14.6 1.8 0.068 13.0 0.5 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4386) Polysacc_deac_1 PF01522.21 EXF84674.1 - 1.5e-26 92.7 0.0 5.2e-26 91.0 0.0 1.9 2 1 0 2 2 2 1 Polysaccharide deacetylase Chitin_bind_1 PF00187.19 EXF84674.1 - 4.2e-23 81.5 66.7 5.3e-09 36.4 14.3 3.6 3 0 0 3 3 3 3 Chitin recognition protein Cyclin_N PF00134.23 EXF84675.1 - 5.1e-44 149.1 0.0 2e-43 147.1 0.0 1.9 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 EXF84675.1 - 3.1e-34 117.6 0.0 5.2e-34 116.9 0.0 1.4 1 0 0 1 1 1 1 Cyclin, C-terminal domain Ribosomal_L2_C PF03947.18 EXF84676.1 - 1.6e-51 173.8 2.6 3.6e-51 172.6 1.9 2.1 2 0 0 2 2 2 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 EXF84676.1 - 1.4e-25 89.0 1.2 2.1e-25 88.5 0.4 1.7 2 0 0 2 2 2 1 Ribosomal Proteins L2, RNA binding domain RGS-like PF09128.11 EXF84677.1 - 0.0039 16.9 0.1 0.0046 16.7 0.1 1.1 1 0 0 1 1 1 1 Regulator of G protein signalling-like domain OHCU_decarbox PF09349.10 EXF84677.1 - 0.013 16.0 0.8 0.021 15.3 0.8 1.2 1 0 0 1 1 1 0 OHCU decarboxylase PEP-utilisers_N PF05524.13 EXF84677.1 - 0.023 14.9 0.4 0.03 14.5 0.4 1.2 1 0 0 1 1 1 0 PEP-utilising enzyme, N-terminal OmpH PF03938.14 EXF84677.1 - 0.024 15.0 3.2 0.031 14.6 3.2 1.1 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF3987 PF13148.6 EXF84677.1 - 0.027 13.5 0.8 0.029 13.4 0.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) Peptidase_S49_N PF08496.10 EXF84677.1 - 0.42 10.7 3.9 0.57 10.2 3.9 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal GA-like PF17573.2 EXF84677.1 - 6 6.9 9.8 9.2 6.3 9.8 1.3 1 0 0 1 1 1 0 GA-like domain Borealin PF10512.9 EXF84678.1 - 0.042 13.8 0.4 0.045 13.7 0.4 1.1 1 0 0 1 1 1 0 Cell division cycle-associated protein 8 Ion_trans PF00520.31 EXF84679.1 - 1.6e-121 404.2 79.2 1.2e-42 145.9 11.3 4.7 4 1 0 4 4 4 4 Ion transport protein JSRP PF15312.6 EXF84679.1 - 0.047 13.6 0.1 0.16 11.9 0.1 1.9 1 0 0 1 1 1 0 Junctional sarcoplasmic reticulum protein GPHH PF16905.5 EXF84679.1 - 0.1 12.4 0.0 0.23 11.2 0.0 1.6 1 0 0 1 1 1 0 Voltage-dependent L-type calcium channel, IQ-associated PHD PF00628.29 EXF84680.1 - 1.4e-09 37.6 9.2 3e-09 36.6 9.2 1.6 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 EXF84680.1 - 0.008 15.7 6.0 0.015 14.8 6.0 1.5 1 0 0 1 1 1 1 PHD-finger Tti2 PF10521.9 EXF84680.1 - 0.11 12.0 5.4 0.19 11.3 5.4 1.3 1 0 0 1 1 1 0 Tti2 family Endostatin PF06482.11 EXF84680.1 - 7.2 6.0 13.6 5.1 6.5 6.9 2.9 3 1 0 3 3 3 0 Collagenase NC10 and Endostatin HMG_box PF00505.19 EXF84682.1 - 1.3e-13 51.1 0.3 2.9e-12 46.8 0.1 2.4 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EXF84682.1 - 0.00042 20.9 0.0 0.0011 19.5 0.0 1.7 1 0 0 1 1 1 1 HMG-box domain MATalpha_HMGbox PF04769.12 EXF84682.1 - 0.0017 17.7 0.1 0.0024 17.2 0.1 1.3 1 0 0 1 1 1 1 Mating-type protein MAT alpha 1 HMG-box MMgT PF10270.9 EXF84683.1 - 4.6e-34 116.8 0.0 5.5e-34 116.5 0.0 1.1 1 0 0 1 1 1 1 Membrane magnesium transporter MutS_V PF00488.21 EXF84684.1 - 1.7e-46 158.7 0.5 4.2e-46 157.3 0.2 1.8 2 0 0 2 2 2 1 MutS domain V MutS_III PF05192.18 EXF84684.1 - 3.3e-20 73.1 0.1 5.6e-20 72.4 0.1 1.4 1 0 0 1 1 1 1 MutS domain III CorA PF01544.18 EXF84685.1 - 1.1e-05 25.0 0.2 2.1e-05 24.0 0.2 1.5 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein Nitrophorin PF02087.15 EXF84685.1 - 0.14 12.1 0.0 0.33 10.9 0.0 1.5 1 0 0 1 1 1 0 Nitrophorin Mersacidin PF16934.5 EXF84686.1 - 6.3 6.6 9.1 10 5.9 2.0 2.6 1 1 1 2 2 2 0 Two-component Enterococcus faecalis cytolysin (EFC) WD40 PF00400.32 EXF84689.1 - 4.5e-12 46.3 4.3 0.21 12.5 0.1 6.5 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EXF84689.1 - 0.02 15.2 0.1 3 8.2 0.0 3.3 3 2 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain DUF2020 PF09449.10 EXF84689.1 - 0.07 13.0 0.1 1.4 8.7 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF2020) A_deaminase PF00962.22 EXF84690.1 - 1.5e-122 409.1 0.1 2e-122 408.6 0.1 1.2 1 0 0 1 1 1 1 Adenosine/AMP deaminase UAA PF08449.11 EXF84690.1 - 2.4e-104 348.8 6.2 3.3e-104 348.3 6.2 1.2 1 0 0 1 1 1 1 UAA transporter family Nuc_sug_transp PF04142.15 EXF84690.1 - 1.7e-06 27.5 0.1 1.7e-06 27.5 0.1 1.6 2 0 0 2 2 2 1 Nucleotide-sugar transporter TMEM234 PF10639.9 EXF84690.1 - 1.6 8.8 4.0 15 5.7 1.0 2.4 2 0 0 2 2 2 0 Putative transmembrane family 234 SHD1 PF03983.12 EXF84691.1 - 4.7e-35 119.2 0.0 8.3e-35 118.4 0.0 1.4 1 0 0 1 1 1 1 SLA1 homology domain 1, SHD1 SH3_9 PF14604.6 EXF84691.1 - 2.8e-32 110.3 11.4 3.1e-11 43.0 0.3 3.7 4 0 0 4 4 4 3 Variant SH3 domain SH3_1 PF00018.28 EXF84691.1 - 3.4e-32 109.8 8.8 1e-12 47.5 0.2 4.2 4 0 0 4 4 4 3 SH3 domain SH3_2 PF07653.17 EXF84691.1 - 3.2e-22 78.0 0.5 5.5e-07 29.2 0.0 4.4 4 0 0 4 4 4 3 Variant SH3 domain DUF1720 PF08226.11 EXF84691.1 - 3.1e-06 27.5 53.0 4.9e-06 26.9 28.7 6.0 1 1 4 5 5 5 2 Domain of unknown function (DUF1720) SH3_3 PF08239.11 EXF84691.1 - 4.4e-05 23.7 6.4 0.015 15.6 1.2 3.3 3 0 0 3 3 3 2 Bacterial SH3 domain SAM_4 PF18017.1 EXF84691.1 - 0.0012 18.8 0.0 0.0025 17.7 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SH3_10 PF17902.1 EXF84691.1 - 0.069 13.2 0.3 0.27 11.3 0.1 2.1 2 0 0 2 2 2 0 SH3 domain TRAM_LAG1_CLN8 PF03798.16 EXF84692.1 - 8.9e-49 165.9 15.4 8.9e-49 165.9 15.4 1.5 2 0 0 2 2 2 1 TLC domain Curto_V3 PF07436.11 EXF84692.1 - 4.8 7.6 5.1 37 4.8 0.0 3.2 3 0 0 3 3 3 0 Curtovirus V3 protein Dor1 PF04124.12 EXF84693.1 - 3.8e-56 190.2 2.0 3.4e-45 154.2 3.6 2.1 2 0 0 2 2 2 2 Dor1-like family Syntaxin-6_N PF09177.11 EXF84693.1 - 0.096 13.3 1.2 1 9.9 0.5 2.6 2 0 0 2 2 2 0 Syntaxin 6, N-terminal Mito_carr PF00153.27 EXF84694.1 - 9.7e-47 156.8 2.3 4.4e-17 61.8 0.1 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein MDM10 PF12519.8 EXF84694.1 - 0.025 13.5 0.7 0.037 12.9 0.7 1.2 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 AAA_21 PF13304.6 EXF84695.1 - 6.9 6.4 7.7 13 5.5 7.7 1.6 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system Prefoldin_2 PF01920.20 EXF84696.1 - 4.2e-18 65.3 2.8 5e-18 65.0 2.6 1.2 1 1 0 1 1 1 1 Prefoldin subunit TMF_TATA_bd PF12325.8 EXF84696.1 - 0.00081 19.6 3.9 0.0037 17.5 0.2 2.1 2 0 0 2 2 2 1 TATA element modulatory factor 1 TATA binding DUF641 PF04859.12 EXF84696.1 - 0.017 15.5 2.2 0.66 10.3 0.1 2.1 2 0 0 2 2 2 0 Plant protein of unknown function (DUF641) Urocanase_N PF17391.2 EXF84696.1 - 0.093 12.4 0.0 0.13 11.9 0.0 1.2 1 0 0 1 1 1 0 Urocanase N-terminal domain CENP-H PF05837.12 EXF84696.1 - 0.17 12.3 5.7 1.7 9.1 0.2 2.1 2 0 0 2 2 2 0 Centromere protein H (CENP-H) Uso1_p115_C PF04871.13 EXF84696.1 - 0.2 12.0 3.7 0.88 9.9 0.2 2.0 2 0 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region CC2-LZ PF16516.5 EXF84696.1 - 0.25 11.7 5.2 1.1 9.7 1.1 2.1 2 0 0 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator PKcGMP_CC PF16808.5 EXF84696.1 - 0.26 11.2 3.1 0.32 10.9 0.5 2.2 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase MscS_porin PF12795.7 EXF84696.1 - 0.55 9.7 11.9 0.27 10.7 4.2 2.1 2 0 0 2 2 2 0 Mechanosensitive ion channel porin domain FlaC_arch PF05377.11 EXF84696.1 - 1.3 9.4 4.2 8 6.9 0.2 2.6 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) IFT20 PF14931.6 EXF84696.1 - 1.9 8.6 7.9 0.72 10.0 1.1 2.1 2 0 0 2 2 2 0 Intraflagellar transport complex B, subunit 20 Swi5 PF07061.11 EXF84696.1 - 3.7 7.7 7.6 3.2 7.9 0.9 2.3 2 1 0 2 2 2 0 Swi5 ABC_tran_CTD PF16326.5 EXF84696.1 - 6.5 7.1 8.5 14 6.1 0.5 2.2 2 0 0 2 2 2 0 ABC transporter C-terminal domain Ceramidase PF05875.12 EXF84697.1 - 1.3e-89 300.1 9.4 1.5e-89 299.9 9.4 1.0 1 0 0 1 1 1 1 Ceramidase TMF_TATA_bd PF12325.8 EXF84698.1 - 2.2e-41 140.7 7.5 2.2e-41 140.7 7.5 6.3 2 1 2 6 6 6 3 TATA element modulatory factor 1 TATA binding TMF_DNA_bd PF12329.8 EXF84698.1 - 8e-14 51.4 0.5 8e-14 51.4 0.5 7.8 5 3 2 8 8 8 1 TATA element modulatory factor 1 DNA binding ATG16 PF08614.11 EXF84698.1 - 0.00029 21.1 4.1 0.00029 21.1 4.1 6.3 2 1 4 7 7 7 3 Autophagy protein 16 (ATG16) DivIC PF04977.15 EXF84698.1 - 0.017 14.9 0.4 0.017 14.9 0.4 8.4 4 3 4 8 8 8 0 Septum formation initiator COG5 PF10392.9 EXF84698.1 - 0.026 14.7 0.9 0.026 14.7 0.9 4.1 3 1 1 4 4 4 0 Golgi transport complex subunit 5 DUF948 PF06103.11 EXF84698.1 - 2 8.7 20.3 4.6 7.6 1.2 5.7 5 1 1 6 6 6 0 Bacterial protein of unknown function (DUF948) CENP-F_leu_zip PF10473.9 EXF84698.1 - 3.8 7.5 64.3 0.27 11.3 7.2 5.6 3 1 0 5 5 5 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Ank_2 PF12796.7 EXF84699.1 - 1.3e-37 128.3 3.8 2.3e-12 47.3 0.7 3.5 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EXF84699.1 - 7.3e-34 115.4 3.6 4.5e-09 36.4 0.1 5.3 1 1 3 5 5 5 5 Ankyrin repeats (many copies) Ank_4 PF13637.6 EXF84699.1 - 1.3e-30 105.4 2.7 7e-10 39.2 0.1 5.0 2 2 3 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EXF84699.1 - 1.1e-27 93.0 0.1 0.0021 18.4 0.0 6.3 6 0 0 6 6 6 6 Ankyrin repeat Ank PF00023.30 EXF84699.1 - 2.3e-22 78.4 4.7 5.2e-05 23.5 0.0 6.3 6 0 0 6 6 6 6 Ankyrin repeat Chlorophyllase PF07224.11 EXF84699.1 - 0.087 11.8 0.0 0.1 11.6 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase WD40 PF00400.32 EXF84700.1 - 1.9e-44 148.8 18.0 6.7e-09 36.2 0.3 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EXF84700.1 - 0.0001 22.5 0.2 11 6.3 0.0 4.6 1 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EXF84700.1 - 0.017 13.8 1.7 13 4.3 0.0 4.0 1 1 3 4 4 4 0 Nucleoporin Nup120/160 AAA PF00004.29 EXF84701.1 - 4.2e-17 62.8 0.1 5.7e-16 59.1 0.0 2.5 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_10 PF17872.1 EXF84701.1 - 3.3e-11 43.2 0.2 8.1e-11 41.9 0.2 1.6 1 0 0 1 1 1 1 AAA lid domain AAA_16 PF13191.6 EXF84701.1 - 1.9e-10 41.4 0.0 1.4e-09 38.5 0.0 2.4 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EXF84701.1 - 1.3e-09 38.5 0.0 8e-08 32.6 0.0 2.8 3 0 0 3 3 3 1 AAA domain BAH PF01426.18 EXF84701.1 - 2.5e-08 33.8 0.0 6.8e-08 32.4 0.0 1.7 1 0 0 1 1 1 1 BAH domain AAA_19 PF13245.6 EXF84701.1 - 0.0019 18.6 0.0 0.0056 17.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 EXF84701.1 - 0.0045 16.9 0.0 0.087 12.7 0.0 2.3 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea NACHT PF05729.12 EXF84701.1 - 0.012 15.5 0.0 0.024 14.6 0.0 1.5 1 0 0 1 1 1 0 NACHT domain DUF2075 PF09848.9 EXF84701.1 - 0.014 14.6 0.0 0.024 13.9 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_11 PF13086.6 EXF84701.1 - 0.017 14.9 0.0 0.033 14.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EXF84701.1 - 0.03 14.9 0.0 0.066 13.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_32 PF13654.6 EXF84701.1 - 0.12 11.1 0.0 0.18 10.5 0.0 1.2 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EXF84701.1 - 0.12 12.7 0.0 0.5 10.8 0.0 2.1 2 0 0 2 2 2 0 RNA helicase tRNA-synt_1 PF00133.22 EXF84702.1 - 7.8e-221 734.5 0.0 1.6e-220 733.5 0.0 1.5 2 0 0 2 2 2 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 EXF84702.1 - 1.7e-25 89.8 0.0 5.4e-25 88.1 0.0 1.8 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 EXF84702.1 - 8.1e-15 54.5 0.0 1.4e-05 24.0 0.0 4.0 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 EXF84702.1 - 0.0046 16.4 0.0 0.043 13.2 0.0 2.3 3 0 0 3 3 3 1 tRNA synthetases class I (C) catalytic domain Mo25 PF08569.11 EXF84703.1 - 2.4e-130 434.7 0.1 2.7e-130 434.5 0.1 1.0 1 0 0 1 1 1 1 Mo25-like DNA_topoisoIV PF00521.20 EXF84703.1 - 0.0097 14.8 0.0 0.019 13.8 0.0 1.4 1 0 0 1 1 1 1 DNA gyrase/topoisomerase IV, subunit A adh_short PF00106.25 EXF84704.1 - 1.3e-36 125.9 0.0 1.7e-36 125.5 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF84704.1 - 3.9e-29 101.9 0.0 5e-29 101.5 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF84704.1 - 6.4e-05 22.9 0.1 9.7e-05 22.3 0.1 1.2 1 0 0 1 1 1 1 KR domain PCMT PF01135.19 EXF84704.1 - 0.042 13.6 0.0 0.066 13.0 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) 3HCDH_N PF02737.18 EXF84704.1 - 0.052 13.4 0.1 0.091 12.6 0.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 EXF84704.1 - 0.056 12.8 0.1 0.12 11.8 0.1 1.5 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Methyltransf_31 PF13847.6 EXF84704.1 - 0.063 13.1 0.0 0.1 12.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Epimerase PF01370.21 EXF84704.1 - 0.063 12.7 0.1 0.15 11.5 0.1 1.6 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family Sacchrp_dh_NADP PF03435.18 EXF84704.1 - 0.13 12.5 0.1 0.23 11.7 0.1 1.3 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain SWIB PF02201.18 EXF84705.1 - 7.4e-23 80.2 0.0 1.8e-22 79.0 0.0 1.7 2 0 0 2 2 2 1 SWIB/MDM2 domain DUF4512 PF14975.6 EXF84705.1 - 0.76 10.6 2.2 0.63 10.8 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4512) Pkinase PF00069.25 EXF84706.1 - 7.7e-69 232.0 0.0 1.1e-68 231.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF84706.1 - 2.7e-35 121.9 0.0 4.1e-33 114.8 0.0 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EXF84706.1 - 2e-05 24.1 0.4 0.013 14.9 0.0 2.6 2 1 0 2 2 2 2 Kinase-like Haspin_kinase PF12330.8 EXF84706.1 - 0.0019 17.2 0.1 0.0032 16.5 0.1 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EXF84706.1 - 0.0031 16.9 0.0 0.0051 16.2 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EXF84706.1 - 0.0063 16.5 0.1 0.014 15.3 0.1 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family FTA2 PF13095.6 EXF84706.1 - 0.026 14.1 0.2 2.6 7.6 0.0 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 MHYT PF03707.16 EXF84707.1 - 1.4e-17 63.6 20.1 1.7e-10 40.9 1.1 4.1 4 0 0 4 4 4 3 Bacterial signalling protein N terminal repeat DUF4131 PF13567.6 EXF84707.1 - 6.4 6.4 10.3 2.9 7.5 1.7 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) WD40 PF00400.32 EXF84708.1 - 1.5e-20 73.1 14.8 2.5e-07 31.3 0.1 6.6 7 1 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EXF84708.1 - 0.0028 17.9 0.1 9.8 6.6 0.0 4.1 4 0 0 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain VCBS PF13517.6 EXF84708.1 - 0.4 11.3 1.9 3.6 8.2 0.0 2.9 3 0 0 3 3 3 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella WW PF00397.26 EXF84709.1 - 9.9e-10 38.3 0.2 2.5e-09 37.0 0.2 1.8 1 0 0 1 1 1 1 WW domain Pga1 PF10333.9 EXF84710.1 - 1e-05 25.5 0.2 5.5e-05 23.1 0.2 2.3 1 1 0 1 1 1 1 GPI-Mannosyltransferase II co-activator Tubulin PF00091.25 EXF84711.1 - 1.4e-66 224.5 0.0 2.1e-66 223.9 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EXF84711.1 - 7.8e-50 168.3 0.1 1.3e-49 167.5 0.1 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 EXF84711.1 - 0.003 17.2 0.0 0.0074 16.0 0.0 1.7 2 0 0 2 2 2 1 Tubulin domain EF-hand_4 PF12763.7 EXF84712.1 - 1.5e-31 108.4 0.0 5.4e-12 45.6 0.0 3.4 3 0 0 3 3 3 3 Cytoskeletal-regulatory complex EF hand EF-hand_7 PF13499.6 EXF84712.1 - 3.5e-07 30.6 0.0 0.0017 18.8 0.0 4.1 4 0 0 4 4 4 1 EF-hand domain pair UBA PF00627.31 EXF84712.1 - 9.4e-07 28.6 0.1 2e-06 27.5 0.1 1.5 1 0 0 1 1 1 1 UBA/TS-N domain TMF_TATA_bd PF12325.8 EXF84712.1 - 0.00034 20.8 26.5 0.024 14.9 4.1 3.3 1 1 2 3 3 3 2 TATA element modulatory factor 1 TATA binding CENP-F_leu_zip PF10473.9 EXF84712.1 - 0.00035 20.6 31.5 0.0026 17.8 12.6 3.1 1 1 2 3 3 3 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 EF-hand_1 PF00036.32 EXF84712.1 - 0.001 18.5 0.0 36 4.2 0.0 4.7 5 0 0 5 5 5 0 EF hand TolA_bind_tri PF16331.5 EXF84712.1 - 0.0023 18.0 35.6 0.52 10.4 2.2 4.6 2 1 2 4 4 4 3 TolA binding protein trimerisation Spc7 PF08317.11 EXF84712.1 - 0.0024 16.8 31.3 0.12 11.3 16.4 2.2 1 1 1 2 2 2 2 Spc7 kinetochore protein BicD PF09730.9 EXF84712.1 - 0.0035 15.9 20.9 0.0053 15.2 20.9 1.2 1 0 0 1 1 1 1 Microtubule-associated protein Bicaudal-D EF-hand_6 PF13405.6 EXF84712.1 - 0.01 15.7 0.0 18 5.6 0.0 4.0 5 0 0 5 5 3 0 EF-hand domain GAS PF13851.6 EXF84712.1 - 0.012 15.0 33.4 0.039 13.3 13.3 2.2 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding DUF3584 PF12128.8 EXF84712.1 - 0.042 11.4 26.4 0.06 10.9 26.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) TPR_MLP1_2 PF07926.12 EXF84712.1 - 0.043 13.9 36.3 0.23 11.5 19.6 2.3 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein YkyA PF10368.9 EXF84712.1 - 0.054 13.2 26.9 0.2 11.3 3.1 3.0 2 1 1 3 3 3 0 Putative cell-wall binding lipoprotein SOGA PF11365.8 EXF84712.1 - 0.073 14.2 20.7 0.29 12.3 4.8 2.6 2 1 0 2 2 2 0 Protein SOGA ATG16 PF08614.11 EXF84712.1 - 0.078 13.2 39.2 0.88 9.8 14.4 3.4 2 1 1 3 3 2 0 Autophagy protein 16 (ATG16) LPP PF04728.13 EXF84712.1 - 0.088 13.2 16.6 0.52 10.8 1.0 4.2 3 1 2 5 5 5 0 Lipoprotein leucine-zipper SYCE1 PF15233.6 EXF84712.1 - 0.1 12.6 25.4 0.11 12.5 17.7 2.2 1 1 1 2 2 2 0 Synaptonemal complex central element protein 1 PRKG1_interact PF15898.5 EXF84712.1 - 0.11 13.4 29.8 0.08 13.8 9.2 3.2 1 1 2 3 3 3 0 cGMP-dependent protein kinase interacting domain ADIP PF11559.8 EXF84712.1 - 0.13 12.4 39.1 0.15 12.1 14.7 3.3 1 1 3 4 4 4 0 Afadin- and alpha -actinin-Binding MbeD_MobD PF04899.12 EXF84712.1 - 0.43 10.7 20.8 1.9 8.7 1.3 4.5 2 1 2 4 4 4 0 MbeD/MobD like DUF1664 PF07889.12 EXF84712.1 - 0.46 10.5 17.5 0.67 10.0 3.9 2.4 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) HAP1_N PF04849.13 EXF84712.1 - 0.57 9.3 28.5 0.44 9.7 16.3 2.1 1 1 1 2 2 2 0 HAP1 N-terminal conserved region Macoilin PF09726.9 EXF84712.1 - 0.86 8.1 17.4 1.7 7.1 17.4 1.4 1 0 0 1 1 1 0 Macoilin family kleA_kleC PF17383.2 EXF84712.1 - 0.91 9.9 6.8 22 5.5 1.6 3.3 2 1 1 3 3 3 0 Uncharacterized KorC regulated protein A Laminin_I PF06008.14 EXF84712.1 - 1.3 8.6 28.1 0.36 10.5 7.7 2.5 1 1 0 2 2 2 0 Laminin Domain I Fez1 PF06818.15 EXF84712.1 - 1.4 9.4 28.7 10 6.6 25.4 2.2 1 1 1 2 2 2 0 Fez1 MscS_porin PF12795.7 EXF84712.1 - 1.6 8.2 41.7 2.4 7.6 25.4 2.2 1 1 1 2 2 2 0 Mechanosensitive ion channel porin domain APG6_N PF17675.1 EXF84712.1 - 2.2 8.8 33.4 13 6.4 11.7 3.2 1 1 1 2 2 2 0 Apg6 coiled-coil region DivIC PF04977.15 EXF84712.1 - 2.7 7.8 30.2 0.066 13.0 7.8 4.1 1 1 3 4 4 4 0 Septum formation initiator Golgin_A5 PF09787.9 EXF84712.1 - 3 7.2 31.1 6.7 6.1 11.0 1.9 1 1 1 2 2 2 0 Golgin subfamily A member 5 bZIP_2 PF07716.15 EXF84712.1 - 3.3 7.9 11.2 3 8.0 5.0 2.9 2 0 0 2 2 2 0 Basic region leucine zipper Filament PF00038.21 EXF84712.1 - 3.9 7.0 29.9 1.3 8.5 10.5 2.1 1 1 1 2 2 2 0 Intermediate filament protein DUF724 PF05266.14 EXF84712.1 - 4.3 7.1 24.1 0.31 10.8 8.2 3.0 1 1 2 3 3 3 0 Protein of unknown function (DUF724) AAA_13 PF13166.6 EXF84712.1 - 5.9 5.4 21.8 22 3.5 21.5 1.8 1 1 0 1 1 1 0 AAA domain EzrA PF06160.12 EXF84712.1 - 8.1 4.5 24.5 31 2.6 24.6 1.8 1 1 0 1 1 1 0 Septation ring formation regulator, EzrA Sec6 PF06046.13 EXF84713.1 - 8.9e-169 562.5 10.3 1.5e-168 561.8 10.3 1.3 1 0 0 1 1 1 1 Exocyst complex component Sec6 Vps53_N PF04100.12 EXF84713.1 - 0.0053 15.8 1.3 0.0053 15.8 1.3 2.2 2 1 1 3 3 3 1 Vps53-like, N-terminal OmdA PF13376.6 EXF84713.1 - 0.074 13.1 0.8 0.29 11.2 0.0 2.5 3 0 0 3 3 3 0 Bacteriocin-protection, YdeI or OmpD-Associated DUF3829 PF12889.7 EXF84713.1 - 0.15 11.5 2.5 1.9 7.9 0.7 2.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3829) DUF755 PF05501.11 EXF84713.1 - 0.22 11.8 0.5 0.43 10.9 0.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF755) Pirin PF02678.16 EXF84714.1 - 6e-30 103.4 0.1 1.3e-29 102.4 0.1 1.6 1 0 0 1 1 1 1 Pirin Pirin_C PF05726.13 EXF84714.1 - 6e-26 90.8 0.0 1.2e-24 86.6 0.1 2.2 2 0 0 2 2 2 1 Pirin C-terminal cupin domain Cupin_2 PF07883.11 EXF84714.1 - 1.1e-06 28.2 2.8 0.00011 21.8 0.7 2.8 2 0 0 2 2 2 2 Cupin domain Cupin_3 PF05899.12 EXF84714.1 - 0.11 12.2 0.8 0.72 9.6 0.0 2.6 3 1 0 3 3 3 0 Protein of unknown function (DUF861) Perilipin PF03036.16 EXF84715.1 - 0.00034 19.8 0.0 0.00053 19.1 0.0 1.3 1 0 0 1 1 1 1 Perilipin family DENN PF02141.21 EXF84718.1 - 7.8e-40 136.8 0.1 1.3e-39 136.0 0.1 1.4 1 0 0 1 1 1 1 DENN (AEX-3) domain uDENN PF03456.18 EXF84718.1 - 4.4e-07 30.6 0.3 2.8e-06 28.0 0.0 2.4 2 0 0 2 2 2 1 uDENN domain Elongin_A PF06881.11 EXF84718.1 - 0.0054 17.2 6.7 0.025 15.1 6.7 2.1 1 0 0 1 1 1 1 RNA polymerase II transcription factor SIII (Elongin) subunit A IFT57 PF10498.9 EXF84718.1 - 0.0063 15.5 5.6 0.0063 15.5 5.6 2.3 2 1 1 3 3 3 1 Intra-flagellar transport protein 57 DUF5345 PF17280.2 EXF84718.1 - 0.26 11.3 0.8 0.82 9.7 0.8 1.8 1 0 0 1 1 1 0 Family of unknown function (DUF5345) TMF_TATA_bd PF12325.8 EXF84718.1 - 4.1 7.7 15.6 5.3 7.3 3.8 2.7 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding zf-HIT PF04438.16 EXF84719.1 - 4.7e-09 36.0 9.1 7e-09 35.4 9.1 1.3 1 0 0 1 1 1 1 HIT zinc finger MPP6 PF10175.9 EXF84719.1 - 0.074 13.6 4.3 0.15 12.6 4.3 1.5 1 0 0 1 1 1 0 M-phase phosphoprotein 6 CFEM PF05730.11 EXF84720.1 - 1.4e-08 34.7 8.1 2.7e-08 33.8 8.1 1.4 1 0 0 1 1 1 1 CFEM domain Ribonuc_red_lgC PF02867.15 EXF84721.1 - 7.9e-194 645.0 0.0 1e-193 644.6 0.0 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.21 EXF84721.1 - 2.9e-24 84.9 0.0 6.3e-23 80.6 0.0 2.6 2 0 0 2 2 2 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.16 EXF84721.1 - 2.2e-15 57.0 0.0 4.8e-15 55.9 0.0 1.6 1 0 0 1 1 1 1 ATP cone domain Prok-E2_B PF14461.6 EXF84721.1 - 0.0039 16.9 0.0 0.0093 15.7 0.0 1.6 1 0 0 1 1 1 1 Prokaryotic E2 family B TatD_DNase PF01026.21 EXF84722.1 - 2.3e-48 164.8 0.0 5e-48 163.7 0.0 1.5 1 1 0 1 1 1 1 TatD related DNase CENP-N PF05238.13 EXF84723.1 - 8.7e-138 460.1 0.0 9.8e-138 459.9 0.0 1.0 1 0 0 1 1 1 1 Kinetochore protein CHL4 like bZIP_2 PF07716.15 EXF84725.1 - 4.5e-12 45.9 12.2 7e-12 45.2 12.2 1.3 1 0 0 1 1 1 1 Basic region leucine zipper LCD1 PF09798.9 EXF84725.1 - 0.0058 15.2 0.3 0.0058 15.2 0.3 1.1 1 0 0 1 1 1 1 DNA damage checkpoint protein bZIP_1 PF00170.21 EXF84725.1 - 0.025 14.6 11.8 0.061 13.4 11.9 1.6 1 1 0 1 1 1 0 bZIP transcription factor TSC22 PF01166.18 EXF84725.1 - 0.1 12.9 0.9 0.25 11.7 0.5 1.8 1 1 0 1 1 1 0 TSC-22/dip/bun family TssO PF17561.2 EXF84725.1 - 0.15 12.1 3.3 0.23 11.6 3.3 1.2 1 0 0 1 1 1 0 Type VI secretion system, TssO bZIP_Maf PF03131.17 EXF84725.1 - 0.43 11.1 8.8 0.37 11.4 7.1 1.7 1 1 0 1 1 1 0 bZIP Maf transcription factor XhlA PF10779.9 EXF84725.1 - 0.53 10.5 2.9 1.1 9.5 2.9 1.5 1 0 0 1 1 1 0 Haemolysin XhlA YcbB PF08664.10 EXF84725.1 - 1.1 9.2 6.2 1.7 8.7 0.1 2.6 2 0 0 2 2 2 0 YcbB domain FapA PF03961.13 EXF84725.1 - 1.2 7.6 6.4 1.6 7.2 6.4 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A ORC6 PF05460.13 EXF84726.1 - 1.3 8.2 5.8 1.8 7.8 5.8 1.1 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Pneumo_att_G PF05539.11 EXF84726.1 - 5.1 6.6 10.3 6.2 6.3 10.3 1.3 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G VWA PF00092.28 EXF84727.1 - 9.1e-05 22.8 0.0 0.00046 20.5 0.0 1.9 1 1 0 1 1 1 1 von Willebrand factor type A domain vWA-TerF-like PF10138.9 EXF84727.1 - 0.0046 17.1 0.0 0.011 15.9 0.0 1.6 1 1 0 1 1 1 1 vWA found in TerF C terminus DUF4597 PF15366.6 EXF84727.1 - 3.6 7.4 8.4 0.48 10.2 2.8 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4597) ORC6 PF05460.13 EXF84727.1 - 6.6 5.9 7.0 9.5 5.4 7.0 1.2 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Aminotran_1_2 PF00155.21 EXF84728.1 - 2.9e-34 118.8 0.0 3.5e-34 118.6 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II DUF4763 PF15960.5 EXF84729.1 - 0.18 11.1 0.0 0.25 10.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4763) FapA PF03961.13 EXF84730.1 - 0.1 11.2 2.3 0.16 10.6 2.3 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A CCDC-167 PF15188.6 EXF84730.1 - 0.19 12.1 2.4 0.46 10.9 2.4 1.6 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 DUF1664 PF07889.12 EXF84730.1 - 0.34 10.9 0.7 0.65 10.0 0.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) RRM_1 PF00076.22 EXF84731.1 - 1.2e-43 146.8 0.7 8.8e-20 70.3 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RBM39linker PF15519.6 EXF84731.1 - 3.4e-23 82.5 0.1 1.2e-22 80.8 0.1 2.0 1 0 0 1 1 1 1 linker between RRM2 and RRM3 domains in RBM39 protein RRM_occluded PF16842.5 EXF84731.1 - 0.0012 18.7 0.0 0.29 11.0 0.0 3.1 3 0 0 3 3 3 1 Occluded RNA-recognition motif RRM_3 PF08777.11 EXF84731.1 - 0.0041 17.1 1.7 0.1 12.7 0.0 3.1 3 1 0 3 3 3 1 RNA binding motif Nup35_RRM_2 PF14605.6 EXF84731.1 - 0.0047 16.9 0.0 0.68 10.0 0.0 2.8 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif RRM_7 PF16367.5 EXF84731.1 - 0.018 15.2 0.0 1.7 8.8 0.0 2.6 2 0 0 2 2 2 0 RNA recognition motif PHM7_cyt PF14703.6 EXF84731.1 - 0.045 14.0 0.2 1.6 8.9 0.2 3.1 1 1 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter Cyt-b5 PF00173.28 EXF84732.1 - 1.2e-17 63.8 1.8 2.3e-17 62.9 0.2 2.2 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain FA_hydroxylase PF04116.13 EXF84732.1 - 3.8e-11 43.5 19.9 5.9e-11 42.8 19.4 1.6 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily Anth_synt_I_N PF04715.13 EXF84732.1 - 0.052 13.8 0.1 0.094 12.9 0.1 1.4 1 0 0 1 1 1 0 Anthranilate synthase component I, N terminal region Het-C PF07217.11 EXF84733.1 - 2.5e-286 950.7 0.0 3.2e-286 950.3 0.0 1.0 1 0 0 1 1 1 1 Heterokaryon incompatibility protein Het-C TctA PF01970.16 EXF84733.1 - 0.2 10.4 0.0 0.34 9.6 0.0 1.3 1 0 0 1 1 1 0 Tripartite tricarboxylate transporter TctA family PP2C PF00481.21 EXF84734.1 - 4.6e-39 134.6 0.0 2.8e-33 115.6 0.0 2.2 2 0 0 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.6 EXF84734.1 - 0.00012 21.8 0.0 0.00026 20.7 0.0 1.5 1 0 0 1 1 1 1 Protein phosphatase 2C BTB PF00651.31 EXF84735.1 - 0.033 14.4 0.7 11 6.3 0.0 3.0 4 0 0 4 4 4 0 BTB/POZ domain FTR1 PF03239.14 EXF84736.1 - 5.4e-81 272.1 9.7 6.7e-81 271.8 9.7 1.0 1 0 0 1 1 1 1 Iron permease FTR1 family Ferlin_C PF16165.5 EXF84736.1 - 0.091 12.7 1.2 0.15 12.0 0.0 2.1 2 0 0 2 2 2 0 Ferlin C-terminus SUR7 PF06687.12 EXF84736.1 - 2 8.0 9.1 0.31 10.6 2.3 2.4 2 0 0 2 2 2 0 SUR7/PalI family HlyIII PF03006.20 EXF84736.1 - 9.4 5.9 9.4 6.4 6.4 0.6 2.6 3 0 0 3 3 3 0 Haemolysin-III related Cu-oxidase_2 PF07731.14 EXF84737.1 - 1.7e-43 147.6 6.9 1.5e-40 138.1 0.4 2.9 2 1 0 2 2 2 2 Multicopper oxidase Cu-oxidase PF00394.22 EXF84737.1 - 5.6e-42 143.6 1.2 1.2e-37 129.5 0.1 2.8 2 0 0 2 2 2 2 Multicopper oxidase Cu-oxidase_3 PF07732.15 EXF84737.1 - 9.2e-41 138.6 7.2 5.7e-38 129.6 2.5 3.9 4 0 0 4 4 4 2 Multicopper oxidase Cupredoxin_1 PF13473.6 EXF84737.1 - 0.003 17.6 0.0 35 4.6 0.0 3.6 3 0 0 3 3 3 1 Cupredoxin-like domain TRAP_alpha PF03896.16 EXF84737.1 - 0.14 11.3 0.1 0.22 10.7 0.1 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit CDP-OH_P_transf PF01066.21 EXF84738.1 - 1.5e-12 48.1 0.3 1.5e-12 48.1 0.3 2.2 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase OMPdecase PF00215.24 EXF84739.1 - 8.4e-104 346.1 0.0 9.8e-104 345.9 0.0 1.0 1 0 0 1 1 1 1 Orotidine 5'-phosphate decarboxylase / HUMPS family Ank_2 PF12796.7 EXF84740.1 - 1.3e-26 93.0 0.1 3e-09 37.4 0.1 4.3 2 2 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EXF84740.1 - 4.3e-18 65.4 0.8 2.5e-06 27.9 0.0 5.4 3 1 3 6 6 6 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EXF84740.1 - 8.3e-15 54.7 4.6 0.047 14.0 0.0 6.9 3 2 4 7 7 7 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EXF84740.1 - 9.4e-15 53.3 3.9 0.0037 17.7 0.0 7.6 7 0 0 7 7 6 3 Ankyrin repeat Ank PF00023.30 EXF84740.1 - 2.6e-12 46.6 6.5 0.0066 16.9 0.0 6.6 6 0 0 6 6 5 3 Ankyrin repeat NACHT PF05729.12 EXF84740.1 - 1.1e-10 41.6 0.3 3e-09 37.0 0.3 2.5 1 1 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 EXF84740.1 - 1.8e-07 31.7 0.2 7.5e-07 29.7 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain NACHT_N PF17100.5 EXF84740.1 - 1.4e-06 28.3 0.7 9.3e-06 25.6 0.2 2.2 1 1 1 2 2 2 1 N-terminal domain of NWD NACHT-NTPase AAA_22 PF13401.6 EXF84740.1 - 5.7e-06 26.7 0.1 4.3e-05 23.8 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 EXF84740.1 - 0.00057 20.3 0.1 0.006 17.0 0.1 2.4 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DUF2075 PF09848.9 EXF84740.1 - 0.003 16.8 0.0 0.005 16.1 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) KAP_NTPase PF07693.14 EXF84740.1 - 0.0089 15.3 0.1 2.7 7.1 0.0 2.3 2 0 0 2 2 2 2 KAP family P-loop domain ATPase_2 PF01637.18 EXF84740.1 - 0.04 13.8 0.0 0.081 12.8 0.0 1.5 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_19 PF13245.6 EXF84740.1 - 0.042 14.2 0.0 0.82 10.0 0.0 2.8 3 0 0 3 3 3 0 AAA domain TniB PF05621.11 EXF84740.1 - 0.044 13.2 0.3 0.28 10.6 0.0 2.4 3 0 0 3 3 3 0 Bacterial TniB protein NB-ARC PF00931.22 EXF84740.1 - 0.067 12.4 0.0 0.18 11.0 0.0 1.6 1 0 0 1 1 1 0 NB-ARC domain Mg_chelatase PF01078.21 EXF84740.1 - 0.12 11.8 0.0 0.24 10.8 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.12 EXF84740.1 - 0.13 11.5 0.0 0.35 10.1 0.0 1.7 1 0 0 1 1 1 0 Zeta toxin SUKH-4 PF14435.6 EXF84741.1 - 0.035 14.2 0.0 0.035 14.2 0.0 1.1 1 0 0 1 1 1 0 SUKH-4 immunity protein Mus7 PF09462.10 EXF84742.1 - 3.7e-129 432.4 2.0 4.9e-129 432.0 2.0 1.2 1 0 0 1 1 1 1 Mus7/MMS22 family Activator-TraM PF11657.8 EXF84742.1 - 0.028 14.3 1.7 0.3 10.9 0.4 2.4 2 0 0 2 2 2 0 Transcriptional activator TraM AAA PF00004.29 EXF84743.1 - 1.2e-38 132.5 0.2 3.1e-37 128.0 0.0 2.9 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EXF84743.1 - 7.8e-08 32.0 0.3 7.8e-08 32.0 0.3 1.9 2 0 0 2 2 1 1 AAA+ lid domain AAA_16 PF13191.6 EXF84743.1 - 2.5e-06 28.0 0.3 0.0016 18.9 0.0 3.2 2 1 0 3 3 3 1 AAA ATPase domain RuvB_N PF05496.12 EXF84743.1 - 1.2e-05 25.1 0.0 2.5e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EXF84743.1 - 0.00034 20.9 1.2 0.094 13.0 0.1 3.1 2 1 1 3 3 2 1 AAA domain IstB_IS21 PF01695.17 EXF84743.1 - 0.00066 19.5 0.0 0.0017 18.1 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_14 PF13173.6 EXF84743.1 - 0.0017 18.4 0.0 0.0094 16.0 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EXF84743.1 - 0.0022 18.1 0.2 0.016 15.4 0.2 2.4 1 1 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 EXF84743.1 - 0.01 15.8 0.1 5 7.0 0.0 2.7 2 1 1 3 3 3 0 ATPase domain predominantly from Archaea AAA_7 PF12775.7 EXF84743.1 - 0.011 15.2 0.0 1.3 8.5 0.0 2.6 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_5 PF07728.14 EXF84743.1 - 0.014 15.4 0.1 0.039 14.0 0.1 1.8 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) TniB PF05621.11 EXF84743.1 - 0.015 14.7 0.0 0.83 9.0 0.0 2.4 1 1 1 2 2 2 0 Bacterial TniB protein AAA_28 PF13521.6 EXF84743.1 - 0.02 15.1 0.1 0.7 10.1 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 EXF84743.1 - 0.021 15.4 0.0 0.064 13.8 0.0 1.8 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EXF84743.1 - 0.025 14.9 0.0 0.087 13.2 0.0 1.9 1 0 0 1 1 1 0 RNA helicase Mg_chelatase PF01078.21 EXF84743.1 - 0.042 13.2 0.0 0.091 12.1 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_24 PF13479.6 EXF84743.1 - 0.045 13.5 0.0 0.097 12.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain TIP49 PF06068.13 EXF84743.1 - 0.058 12.6 0.0 0.1 11.8 0.0 1.4 1 0 0 1 1 1 0 TIP49 P-loop domain NACHT PF05729.12 EXF84743.1 - 0.12 12.2 0.3 3.1 7.7 0.1 2.8 2 0 0 2 2 2 0 NACHT domain Hydin_ADK PF17213.3 EXF84743.1 - 0.13 12.5 0.3 5.5 7.2 0.0 2.9 3 0 0 3 3 3 0 Hydin Adenylate kinase-like domain ABC_tran PF00005.27 EXF84743.1 - 0.15 12.6 0.0 1 9.8 0.0 2.4 3 0 0 3 3 3 0 ABC transporter AAA_25 PF13481.6 EXF84743.1 - 0.16 11.5 0.5 2.2 7.8 0.1 2.7 3 0 0 3 3 2 0 AAA domain BSD PF03909.17 EXF84744.1 - 7.3e-30 102.8 0.8 1.4e-13 50.7 0.1 2.9 2 0 0 2 2 2 2 BSD domain PH_TFIIH PF08567.11 EXF84744.1 - 3.6e-26 91.3 0.2 1.1e-25 89.7 0.0 1.9 2 0 0 2 2 2 1 TFIIH p62 subunit, N-terminal domain Glyco_hydro_61 PF03443.14 EXF84745.1 - 0.07 13.1 0.9 0.17 11.8 0.1 2.1 2 1 0 2 2 2 0 Glycosyl hydrolase family 61 LsmAD PF06741.13 EXF84746.1 - 2.5e-28 98.4 1.5 2.5e-28 98.4 1.5 2.2 2 0 0 2 2 2 1 LsmAD domain Tantalus PF15386.6 EXF84746.1 - 0.058 13.5 0.0 0.17 12.0 0.0 1.9 1 0 0 1 1 1 0 Drosophila Tantalus-like Peptidase_M16 PF00675.20 EXF84747.1 - 5.9e-16 58.8 0.1 1.2e-15 57.8 0.1 1.4 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 EXF84747.1 - 2.2e-10 40.8 0.0 3.9e-10 40.0 0.0 1.4 1 0 0 1 1 1 1 Peptidase M16 inactive domain RNA_pol_Rpc82 PF05645.13 EXF84748.1 - 8.6e-48 163.3 0.0 9.3e-47 159.9 0.0 2.4 3 0 0 3 3 3 1 RNA polymerase III subunit RPC82 HTH_9 PF08221.11 EXF84748.1 - 5.9e-14 51.9 0.6 1.8e-12 47.2 0.2 2.8 3 0 0 3 3 3 1 RNA polymerase III subunit RPC82 helix-turn-helix domain TFIIE_alpha PF02002.17 EXF84748.1 - 2.7e-06 27.2 0.1 0.0098 15.7 0.0 3.4 3 1 1 4 4 4 2 TFIIE alpha subunit Mito_carr PF00153.27 EXF84749.1 - 6.4e-31 106.1 0.6 1.3e-15 57.0 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Amino_oxidase PF01593.24 EXF84750.1 - 1e-32 114.1 1.1 9e-29 101.0 0.0 2.1 1 1 1 2 2 2 2 Flavin containing amine oxidoreductase Pyr_redox_2 PF07992.14 EXF84750.1 - 7.4e-08 32.0 0.0 4.5e-06 26.1 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EXF84750.1 - 1.8e-06 27.8 0.5 1.6e-05 24.7 0.4 2.1 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EXF84750.1 - 1.2e-05 25.4 1.1 6.6e-05 23.1 0.2 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EXF84750.1 - 1.2e-05 24.6 0.2 4.7e-05 22.6 0.0 1.9 2 0 0 2 2 2 1 FAD binding domain FAD_oxidored PF12831.7 EXF84750.1 - 0.00028 20.4 0.6 0.0087 15.4 0.2 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase HI0933_like PF03486.14 EXF84750.1 - 0.00051 18.9 0.0 0.00083 18.2 0.0 1.3 1 0 0 1 1 1 1 HI0933-like protein Lycopene_cycl PF05834.12 EXF84750.1 - 0.00067 18.8 0.2 0.012 14.7 0.0 2.2 2 0 0 2 2 2 1 Lycopene cyclase protein Thi4 PF01946.17 EXF84750.1 - 0.00097 18.4 0.0 0.0017 17.7 0.0 1.3 1 0 0 1 1 1 1 Thi4 family FAD_binding_3 PF01494.19 EXF84750.1 - 0.0024 17.2 0.1 0.0042 16.4 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.27 EXF84750.1 - 0.0028 18.2 0.1 0.053 14.1 0.0 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EXF84750.1 - 0.011 14.9 0.1 0.022 13.9 0.0 1.5 2 0 0 2 2 2 0 Glucose inhibited division protein A AlaDh_PNT_C PF01262.21 EXF84750.1 - 0.11 11.7 0.0 0.2 10.9 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox_3 PF13738.6 EXF84750.1 - 0.15 11.2 0.0 13 4.9 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Sugar_tr PF00083.24 EXF84751.1 - 6e-103 345.1 17.9 7.3e-103 344.8 17.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF84751.1 - 8.5e-26 90.7 52.6 1.6e-24 86.5 26.7 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EXF84751.1 - 7.4e-08 31.4 21.3 2.7e-05 22.9 6.2 2.9 3 0 0 3 3 3 2 MFS/sugar transport protein MFS_1_like PF12832.7 EXF84751.1 - 0.011 14.6 8.2 0.058 12.2 0.1 2.5 2 1 0 2 2 2 0 MFS_1 like family DUF2530 PF10745.9 EXF84751.1 - 0.34 11.2 3.7 1.8 8.9 0.4 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2530) MFS_3 PF05977.13 EXF84751.1 - 0.81 8.0 5.4 1.3 7.3 0.5 2.1 2 0 0 2 2 2 0 Transmembrane secretion effector PITH PF06201.13 EXF84753.1 - 2.4e-45 154.4 0.0 2.9e-45 154.2 0.0 1.1 1 0 0 1 1 1 1 PITH domain Rrn6 PF10214.9 EXF84754.1 - 6.1e-197 656.9 1.6 1e-196 656.2 1.6 1.3 1 1 0 1 1 1 1 RNA polymerase I-specific transcription-initiation factor MOZART1 PF12554.8 EXF84755.1 - 3.6e-26 90.7 0.7 4.4e-26 90.4 0.7 1.1 1 0 0 1 1 1 1 Mitotic-spindle organizing gamma-tubulin ring associated zinc_ribbon_6 PF14599.6 EXF84756.1 - 1.5e-24 85.8 0.0 1.5e-24 85.8 0.0 4.1 3 1 1 4 4 4 1 Zinc-ribbon zf-CHY PF05495.12 EXF84756.1 - 5.9e-21 74.7 20.7 5.9e-21 74.7 20.7 3.6 3 1 0 3 3 3 1 CHY zinc finger zf-RING_2 PF13639.6 EXF84756.1 - 4.6e-08 33.3 6.8 4.6e-08 33.3 6.8 5.3 2 2 4 6 6 6 1 Ring finger domain zf-RING_UBOX PF13445.6 EXF84756.1 - 2.9e-06 27.2 2.8 2.9e-06 27.2 2.8 3.9 5 1 0 5 5 5 1 RING-type zinc-finger zf-RING_5 PF14634.6 EXF84756.1 - 6.3e-06 26.0 6.8 6.3e-06 26.0 6.8 6.7 3 2 1 4 4 4 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 EXF84756.1 - 6.6e-05 22.7 7.4 6.6e-05 22.7 7.4 5.0 3 2 3 6 6 6 1 Zinc finger, C3HC4 type (RING finger) RNA_pol_3_Rpc31 PF11705.8 EXF84756.1 - 0.0057 16.9 1.5 0.0099 16.2 1.5 1.4 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 Cwf_Cwc_15 PF04889.12 EXF84756.1 - 1.3 8.7 5.9 2.4 7.8 5.9 1.4 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein PMT PF02366.18 EXF84757.1 - 4.6e-84 281.8 12.0 4.6e-84 281.8 12.0 2.3 2 1 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 EXF84757.1 - 1.5e-66 223.8 15.4 1.5e-66 223.8 15.4 2.0 2 1 0 2 2 2 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 EXF84757.1 - 4.3e-37 127.8 0.3 7.1e-37 127.1 0.3 1.2 1 0 0 1 1 1 1 MIR domain DUF2976 PF11190.8 EXF84757.1 - 7.4 6.4 9.4 0.45 10.4 1.6 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2976) Ras PF00071.22 EXF84758.1 - 5e-50 169.3 0.0 4.8e-39 133.6 0.1 2.1 2 0 0 2 2 2 2 Ras family Roc PF08477.13 EXF84758.1 - 3.2e-29 101.6 0.0 1.1e-18 67.6 0.0 2.2 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EXF84758.1 - 2.3e-10 40.2 0.0 7.2e-10 38.6 0.0 1.7 2 0 0 2 2 2 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EXF84758.1 - 2e-06 27.5 0.1 1.7e-05 24.5 0.0 1.9 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EXF84758.1 - 4.1e-05 23.1 0.0 9.7e-05 21.8 0.0 1.6 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EXF84758.1 - 0.00016 21.7 0.0 0.00052 20.1 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EXF84758.1 - 0.0033 17.4 0.1 1 9.2 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase AAA_22 PF13401.6 EXF84758.1 - 0.063 13.5 0.1 1.4 9.2 0.1 2.3 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 EXF84758.1 - 0.15 11.6 0.1 19 4.8 0.0 2.2 2 0 0 2 2 2 0 AAA domain PduV-EutP PF10662.9 EXF84758.1 - 0.22 11.3 0.1 1.8 8.3 0.0 2.1 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Choline_transpo PF04515.12 EXF84759.1 - 4.8e-28 98.3 21.2 4.8e-28 98.3 21.2 2.3 2 1 0 2 2 2 1 Plasma-membrane choline transporter WW PF00397.26 EXF84760.1 - 1.1e-10 41.3 4.4 2.2e-10 40.4 4.4 1.5 1 0 0 1 1 1 1 WW domain SUIM_assoc PF16619.5 EXF84760.1 - 0.0075 16.3 0.4 0.034 14.2 0.1 2.4 1 1 1 2 2 2 1 Unstructured region C-term to UIM in Ataxin3 M_domain PF12938.7 EXF84761.1 - 2.8 7.7 6.3 3.1 7.5 6.3 1.0 1 0 0 1 1 1 0 M domain of GW182 2OG-FeII_Oxy PF03171.20 EXF84763.1 - 8.3e-14 51.9 0.0 1.5e-13 51.1 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 EXF84763.1 - 2.5e-08 34.7 0.0 4.3e-08 33.9 0.0 1.4 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal adh_short PF00106.25 EXF84764.1 - 3.8e-23 82.0 1.2 1.6e-19 70.1 1.2 2.3 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF84764.1 - 4.5e-14 52.6 0.8 5.7e-07 29.3 0.3 2.2 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 EXF84764.1 - 0.011 15.2 0.0 0.024 14.1 0.0 1.6 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family AIRC PF00731.20 EXF84764.1 - 0.014 15.0 2.1 0.04 13.5 0.8 2.1 2 0 0 2 2 2 0 AIR carboxylase KR PF08659.10 EXF84764.1 - 0.089 12.7 3.8 0.078 12.9 1.4 2.2 2 1 0 2 2 2 0 KR domain Eno-Rase_NADH_b PF12242.8 EXF84764.1 - 0.11 12.2 0.0 0.24 11.2 0.0 1.5 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase PSD2 PF07624.11 EXF84765.1 - 0.017 14.8 0.0 0.042 13.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1585) Cys_Met_Meta_PP PF01053.20 EXF84766.1 - 1e-122 409.4 0.0 1.9e-120 401.9 0.0 2.0 2 0 0 2 2 2 2 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 EXF84766.1 - 1e-08 34.5 0.0 5.6e-08 32.1 0.0 2.1 2 1 1 3 3 3 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 EXF84766.1 - 8.6e-07 28.4 0.0 1.4e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II GDC-P PF02347.16 EXF84766.1 - 0.0042 16.0 0.0 0.0063 15.4 0.0 1.2 1 0 0 1 1 1 1 Glycine cleavage system P-protein Met_gamma_lyase PF06838.11 EXF84766.1 - 0.0075 14.8 0.0 0.011 14.3 0.0 1.3 1 0 0 1 1 1 1 Methionine gamma-lyase DegT_DnrJ_EryC1 PF01041.17 EXF84766.1 - 0.028 13.7 0.5 0.06 12.6 0.5 1.6 1 1 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family TNV_CP PF03898.13 EXF84766.1 - 0.089 12.1 0.5 0.17 11.1 0.5 1.4 1 0 0 1 1 1 0 Satellite tobacco necrosis virus coat protein Unstab_antitox PF09720.10 EXF84766.1 - 0.1 12.7 1.5 0.45 10.6 0.8 2.1 2 0 0 2 2 2 0 Putative addiction module component p450 PF00067.22 EXF84767.1 - 1.6e-39 136.0 0.1 2.6e-39 135.3 0.0 1.3 1 1 0 1 1 1 1 Cytochrome P450 adh_short_C2 PF13561.6 EXF84769.1 - 1.4e-53 181.9 0.0 1.7e-53 181.6 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF84769.1 - 1.2e-43 148.8 0.0 1.5e-43 148.5 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EXF84769.1 - 5.7e-09 36.1 0.0 8.1e-09 35.6 0.0 1.1 1 0 0 1 1 1 1 KR domain PA PF02225.22 EXF84769.1 - 0.12 12.4 1.9 0.22 11.6 1.9 1.4 1 0 0 1 1 1 0 PA domain TRAPPC10 PF12584.8 EXF84771.1 - 2.7e-23 82.4 0.0 7.7e-23 80.9 0.0 1.8 2 0 0 2 2 2 1 Trafficking protein particle complex subunit 10, TRAPPC10 Foie-gras_1 PF11817.8 EXF84771.1 - 0.16 11.5 0.1 0.25 10.9 0.1 1.2 1 0 0 1 1 1 0 Foie gras liver health family 1 IF-2B PF01008.17 EXF84772.1 - 7.5e-78 261.6 2.9 8.9e-78 261.3 2.9 1.0 1 0 0 1 1 1 1 Initiation factor 2 subunit family M20_dimer PF07687.14 EXF84773.1 - 5.3e-19 68.2 0.1 9.7e-19 67.3 0.1 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M20 PF01546.28 EXF84773.1 - 2.2e-18 66.7 0.3 3.2e-17 62.9 0.3 2.0 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M28 PF04389.17 EXF84773.1 - 0.0032 17.2 0.0 0.0048 16.6 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M28 Pkinase PF00069.25 EXF84774.1 - 7.4e-65 218.9 0.0 1.1e-64 218.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF84774.1 - 5.1e-40 137.4 0.0 7.2e-40 136.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EXF84774.1 - 3.7e-09 36.3 0.0 8.5e-09 35.1 0.0 1.5 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 EXF84774.1 - 7.2e-05 21.9 0.2 7.2e-05 21.9 0.2 2.1 2 0 0 2 2 2 1 Haspin like kinase domain APH PF01636.23 EXF84774.1 - 0.00024 21.1 4.9 0.021 14.7 0.2 3.5 2 2 1 3 3 3 2 Phosphotransferase enzyme family Kdo PF06293.14 EXF84774.1 - 0.029 13.7 0.1 0.063 12.6 0.1 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 EXF84774.1 - 0.095 11.7 0.0 0.14 11.2 0.0 1.1 1 0 0 1 1 1 0 Seadornavirus VP7 RIO1 PF01163.22 EXF84774.1 - 2.8 7.5 5.0 0.37 10.4 0.1 1.9 2 0 0 2 2 2 0 RIO1 family Prenyltrans PF00432.21 EXF84775.1 - 4e-32 109.6 8.7 3.4e-06 26.7 0.2 5.9 5 1 0 5 5 5 5 Prenyltransferase and squalene oxidase repeat Ilm1 PF10311.9 EXF84776.1 - 3e-66 222.1 0.1 3.5e-66 221.9 0.1 1.0 1 0 0 1 1 1 1 Increased loss of mitochondrial DNA protein 1 NatB_MDM20 PF09797.9 EXF84777.1 - 2.4e-50 171.6 0.0 5.3e-50 170.4 0.0 1.6 1 0 0 1 1 1 1 N-acetyltransferase B complex (NatB) non catalytic subunit TPR_14 PF13428.6 EXF84777.1 - 0.0077 17.0 0.3 61 4.8 0.0 5.0 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_15 PF13429.6 EXF84777.1 - 0.039 13.2 0.3 0.24 10.6 0.0 2.3 3 0 0 3 3 3 0 Tetratricopeptide repeat zf-RanBP PF00641.18 EXF84777.1 - 1.2 8.6 8.3 2.9 7.3 8.3 1.7 1 0 0 1 1 1 0 Zn-finger in Ran binding protein and others CHCH PF06747.13 EXF84778.1 - 2.2e-06 27.7 2.7 3.4e-06 27.0 2.7 1.3 1 0 0 1 1 1 1 CHCH domain MTCP1 PF08991.10 EXF84778.1 - 0.0054 16.9 1.3 0.0078 16.4 1.3 1.2 1 0 0 1 1 1 1 Mature-T-Cell Proliferation I type Inhibitor_I34 PF10466.9 EXF84778.1 - 0.021 15.4 0.1 0.029 15.0 0.1 1.2 1 0 0 1 1 1 0 Saccharopepsin inhibitor I34 Pet191_N PF10203.9 EXF84778.1 - 0.046 14.0 2.9 0.15 12.4 2.8 1.8 1 1 0 1 1 1 0 Cytochrome c oxidase assembly protein PET191 Cmc1 PF08583.10 EXF84778.1 - 0.13 12.3 2.5 4.1 7.5 0.2 2.3 1 1 1 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like Glyco_hydro_61 PF03443.14 EXF84779.1 - 3.9e-50 170.6 0.8 6.5e-50 169.9 0.8 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 Spiralin PF05215.13 EXF84779.1 - 0.022 14.1 0.0 0.022 14.1 0.0 1.6 2 0 0 2 2 2 0 Spiralin LigB PF02900.18 EXF84781.1 - 4.3e-32 111.3 0.0 7.1e-32 110.6 0.0 1.3 1 0 0 1 1 1 1 Catalytic LigB subunit of aromatic ring-opening dioxygenase Amidohydro_3 PF07969.11 EXF84781.1 - 3.2e-15 56.6 0.4 4.5e-10 39.6 0.0 3.2 3 0 0 3 3 3 2 Amidohydrolase family Amidohydro_1 PF01979.20 EXF84781.1 - 2.1e-11 43.8 0.0 1.6e-09 37.5 0.0 3.2 3 1 0 3 3 3 1 Amidohydrolase family DUF3445 PF11927.8 EXF84782.1 - 1.1e-76 257.4 0.0 1.3e-76 257.1 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3445) GH131_N PF18271.1 EXF84783.1 - 7e-64 216.0 1.3 8.8e-64 215.6 1.3 1.1 1 0 0 1 1 1 1 Glycoside hydrolase 131 catalytic N-terminal domain Herpes_DNAp_acc PF04929.12 EXF84783.1 - 6.7 5.6 15.2 9.5 5.1 15.2 1.3 1 0 0 1 1 1 0 Herpes DNA replication accessory factor adh_short PF00106.25 EXF84784.1 - 3.2e-21 75.7 0.0 7.7e-20 71.2 0.0 2.0 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF84784.1 - 2.9e-12 46.7 0.0 4.5e-12 46.0 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF84784.1 - 1e-05 25.5 0.2 2.1e-05 24.5 0.0 1.4 2 0 0 2 2 2 1 KR domain Epimerase PF01370.21 EXF84784.1 - 0.00019 21.0 0.1 0.00066 19.2 0.1 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family THF_DHG_CYH_C PF02882.19 EXF84784.1 - 0.0084 15.4 0.0 0.015 14.6 0.0 1.3 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain RmlD_sub_bind PF04321.17 EXF84784.1 - 0.11 11.6 0.0 0.15 11.1 0.0 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain SWIB PF02201.18 EXF84785.1 - 7.7e-31 105.8 0.3 1.7e-30 104.7 0.3 1.6 1 0 0 1 1 1 1 SWIB/MDM2 domain DEK_C PF08766.11 EXF84785.1 - 1.2e-15 57.2 1.2 3e-15 55.9 0.8 1.9 2 0 0 2 2 2 1 DEK C terminal domain FXMRP1_C_core PF12235.8 EXF84785.1 - 0.14 12.8 6.5 0.28 11.8 6.5 1.5 1 0 0 1 1 1 0 Fragile X-related 1 protein core C terminal XRCC4 PF06632.12 EXF84785.1 - 0.25 10.1 9.3 0.37 9.6 9.0 1.4 1 1 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 SRP54_N PF02881.19 EXF84785.1 - 0.37 11.0 2.4 1.5 9.1 0.1 2.7 3 0 0 3 3 3 0 SRP54-type protein, helical bundle domain Zn_clus PF00172.18 EXF84786.1 - 1.3e-08 34.9 13.1 1.9e-08 34.3 13.1 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Ribosomal_S10 PF00338.22 EXF84787.1 - 0.14 12.4 0.0 0.22 11.8 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein S10p/S20e UAF_Rrn10 PF05234.11 EXF84788.1 - 0.0067 16.7 0.0 0.042 14.1 0.0 2.0 1 1 0 1 1 1 1 UAF complex subunit Rrn10 WD40 PF00400.32 EXF84789.1 - 1.1e-21 76.8 15.0 2.3e-05 25.0 0.1 5.8 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EXF84789.1 - 2.4e-11 43.8 0.6 0.0071 16.6 0.0 4.3 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EXF84789.1 - 0.0037 16.0 2.6 0.16 10.6 0.0 3.4 2 2 1 4 4 4 1 Nucleoporin Nup120/160 Hira PF07569.11 EXF84789.1 - 0.035 13.8 0.0 0.44 10.2 0.0 2.4 2 1 1 3 3 3 0 TUP1-like enhancer of split RNB PF00773.19 EXF84789.1 - 0.16 11.3 0.1 0.22 10.8 0.1 1.1 1 0 0 1 1 1 0 RNB domain MARVEL PF01284.23 EXF84791.1 - 3.7e-20 72.4 12.3 4.4e-20 72.2 12.3 1.1 1 0 0 1 1 1 1 Membrane-associating domain Solute_trans_a PF03619.16 EXF84791.1 - 0.084 12.4 1.8 0.16 11.5 1.8 1.5 1 1 0 1 1 1 0 Organic solute transporter Ostalpha DUF2976 PF11190.8 EXF84791.1 - 0.73 9.7 4.3 0.78 9.6 0.4 2.3 2 1 1 3 3 3 0 Protein of unknown function (DUF2976) Acyl-CoA_dh_1 PF00441.24 EXF84792.1 - 5.8e-17 62.3 0.0 2.7e-16 60.1 0.0 2.0 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain AidB_N PF18158.1 EXF84792.1 - 6.6e-12 45.6 0.0 1.4e-11 44.6 0.0 1.5 1 0 0 1 1 1 1 Adaptive response protein AidB N-terminal domain Acyl-CoA_dh_M PF02770.19 EXF84792.1 - 5.1e-08 33.0 0.0 1.3e-07 31.7 0.0 1.7 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Tweety PF04906.13 EXF84793.1 - 0.14 10.8 2.2 0.2 10.3 2.2 1.2 1 0 0 1 1 1 0 Tweety SNF2_N PF00176.23 EXF84794.1 - 1.8e-52 178.2 0.2 2.6e-52 177.7 0.2 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain VIGSSK PF14773.6 EXF84794.1 - 9.7e-25 86.5 2.1 3.6e-24 84.7 2.1 2.1 1 0 0 1 1 1 1 Helicase-associated putative binding domain, C-terminal Helicase_C PF00271.31 EXF84794.1 - 1.5e-19 70.4 0.0 2.6e-18 66.4 0.0 2.7 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 EXF84794.1 - 6.1e-08 32.2 0.1 3.6e-07 29.7 0.0 2.2 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase ResIII PF04851.15 EXF84794.1 - 2.3e-07 31.0 0.0 1.9e-06 28.0 0.0 2.6 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit RNA_pol_Rpb2_5 PF04567.17 EXF84794.1 - 0.0062 17.1 0.1 0.14 12.8 0.1 2.8 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 5 AAA_34 PF13872.6 EXF84794.1 - 0.024 13.5 0.6 4.8 6.0 0.1 2.5 2 0 0 2 2 2 0 P-loop containing NTP hydrolase pore-1 Glyco_transf_8 PF01501.20 EXF84795.1 - 1.3e-10 41.3 0.0 1.2e-09 38.1 0.0 2.0 1 1 0 1 1 1 1 Glycosyl transferase family 8 ATG2_CAD PF13329.6 EXF84796.1 - 9.1e-56 187.9 1.8 1.9e-55 186.8 1.5 1.8 2 0 0 2 2 2 1 Autophagy-related protein 2 CAD motif ATG_C PF09333.11 EXF84796.1 - 2e-33 114.6 0.6 1.6e-32 111.7 0.1 2.9 4 0 0 4 4 4 1 Autophagy-related protein C terminal domain Chorein_N PF12624.7 EXF84796.1 - 9.6e-07 28.9 0.1 3.7e-06 27.0 0.1 2.0 2 0 0 2 2 2 1 N-terminal region of Chorein or VPS13 VPS13_C PF16909.5 EXF84796.1 - 0.098 12.4 0.1 0.27 11.0 0.1 1.7 1 0 0 1 1 1 0 Vacuolar-sorting-associated 13 protein C-terminal Amino_oxidase PF01593.24 EXF84797.1 - 2.9e-43 148.8 0.0 7.5e-43 147.4 0.0 1.7 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EXF84797.1 - 1.4e-14 54.1 0.1 3.7e-14 52.7 0.0 1.8 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EXF84797.1 - 8.7e-07 28.5 0.0 7.6e-06 25.4 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EXF84797.1 - 5e-05 23.8 0.1 0.00012 22.5 0.1 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EXF84797.1 - 0.00014 21.1 0.3 0.00032 19.9 0.3 1.6 1 0 0 1 1 1 1 FAD binding domain NAD_binding_9 PF13454.6 EXF84797.1 - 0.00036 20.6 0.1 0.19 11.7 0.1 2.5 2 0 0 2 2 2 2 FAD-NAD(P)-binding DAO PF01266.24 EXF84797.1 - 0.0013 18.4 1.8 0.0015 18.2 0.2 1.9 3 0 0 3 3 3 1 FAD dependent oxidoreductase HI0933_like PF03486.14 EXF84797.1 - 0.0015 17.3 0.1 0.0055 15.5 0.1 1.8 2 0 0 2 2 2 1 HI0933-like protein FAD_binding_3 PF01494.19 EXF84797.1 - 0.013 14.7 1.0 0.021 14.1 1.0 1.2 1 0 0 1 1 1 0 FAD binding domain Thi4 PF01946.17 EXF84797.1 - 0.018 14.3 0.1 0.03 13.6 0.1 1.3 1 0 0 1 1 1 0 Thi4 family FAD_oxidored PF12831.7 EXF84797.1 - 0.024 14.0 0.0 0.034 13.5 0.0 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase 3HCDH_N PF02737.18 EXF84797.1 - 0.03 14.2 0.4 0.077 12.9 0.2 1.8 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Lycopene_cycl PF05834.12 EXF84797.1 - 0.087 11.9 0.4 0.13 11.3 0.4 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein GIDA PF01134.22 EXF84797.1 - 0.35 9.9 1.1 0.43 9.6 0.1 1.6 2 0 0 2 2 2 0 Glucose inhibited division protein A Acyl-CoA_dh_1 PF00441.24 EXF84799.1 - 2.5e-33 115.4 0.9 3.7e-33 114.9 0.9 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Cyt-b5 PF00173.28 EXF84799.1 - 1e-18 67.2 0.0 2.4e-18 66.0 0.0 1.7 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Acyl-CoA_dh_M PF02770.19 EXF84799.1 - 4.5e-18 65.2 0.1 7.9e-18 64.5 0.1 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 EXF84799.1 - 8.5e-13 49.0 0.1 5.1e-12 46.5 0.0 2.1 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 EXF84799.1 - 0.0002 21.7 0.0 0.00037 20.8 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain DUF3666 PF12408.8 EXF84799.1 - 0.15 11.2 0.1 23 4.3 0.0 2.5 2 0 0 2 2 2 0 Ribose-5-phosphate isomerase DUF3963 PF13124.6 EXF84799.1 - 4.5 7.3 4.5 1.4 9.0 0.1 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3963) zf-CCHC PF00098.23 EXF84800.1 - 1.2e-24 85.2 28.3 3.9e-09 36.2 4.0 3.8 4 0 0 4 4 4 3 Zinc knuckle zf-CCHC_4 PF14392.6 EXF84800.1 - 5.8e-07 29.1 12.3 0.0074 16.0 0.6 3.3 3 0 0 3 3 3 3 Zinc knuckle zf-CCHC_3 PF13917.6 EXF84800.1 - 1.4e-05 25.0 15.3 0.058 13.4 0.4 3.4 1 1 2 3 3 3 3 Zinc knuckle zf-CCHC_2 PF13696.6 EXF84800.1 - 2.5e-05 24.0 15.8 0.11 12.3 2.1 3.4 3 0 0 3 3 3 3 Zinc knuckle zf-CCHC_6 PF15288.6 EXF84800.1 - 0.00019 21.2 20.0 0.05 13.5 1.2 3.3 2 1 1 3 3 3 3 Zinc knuckle zf-CCHC_5 PF14787.6 EXF84800.1 - 0.0055 16.4 13.8 0.18 11.6 0.8 3.3 2 1 1 3 3 3 3 GAG-polyprotein viral zinc-finger TRAF6_Z2 PF18048.1 EXF84800.1 - 0.18 11.9 3.5 15 5.7 0.1 3.3 3 0 0 3 3 3 0 TNF receptor-associated factor 6 zinc finger 2 zinc-ribbons_6 PF07191.12 EXF84800.1 - 3.1 7.9 12.1 12 6.0 12.1 1.9 1 1 1 2 2 2 0 zinc-ribbons NinD PF17466.2 EXF84800.1 - 4.1 7.6 11.5 4.6 7.4 5.9 2.6 2 1 0 2 2 2 0 Family of unknown function IBR PF01485.21 EXF84800.1 - 7.3 6.9 14.7 15 5.9 7.5 2.9 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain Ntox16 PF15523.6 EXF84800.1 - 8.1 6.8 12.7 18 5.6 0.6 3.3 2 1 1 3 3 3 0 Novel toxin 16 SAE2 PF08573.10 EXF84802.1 - 2e-35 122.3 0.0 2e-35 122.3 0.0 3.9 5 1 0 5 5 5 1 DNA repair protein endonuclease SAE2/CtIP C-terminus Trimer_CC PF08954.11 EXF84802.1 - 0.01 15.4 0.9 0.046 13.3 0.9 2.2 1 0 0 1 1 1 0 Trimerisation motif KIAA1430 PF13879.6 EXF84802.1 - 0.021 15.5 4.6 0.028 15.2 1.8 2.6 2 1 0 2 2 2 0 KIAA1430 homologue UPF0242 PF06785.11 EXF84802.1 - 0.16 12.1 11.1 0.49 10.5 3.0 2.7 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus BLOC1_2 PF10046.9 EXF84802.1 - 0.68 10.3 3.6 7 7.0 0.2 2.6 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF3496 PF12001.8 EXF84802.1 - 1.1 9.6 4.4 0.27 11.6 0.6 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3496) TPR_MLP1_2 PF07926.12 EXF84802.1 - 3.5 7.7 18.4 0.11 12.6 4.4 2.8 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein HALZ PF02183.18 EXF84802.1 - 5 7.4 7.1 28 5.0 1.5 2.6 2 0 0 2 2 2 0 Homeobox associated leucine zipper Cauli_AT PF03233.13 EXF84802.1 - 7.8 6.4 5.8 1.9 8.4 1.3 2.0 2 0 0 2 2 2 0 Aphid transmission protein UCH PF00443.29 EXF84803.1 - 5.2e-47 160.5 0.0 8.8e-47 159.8 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EXF84803.1 - 3e-09 36.9 0.0 0.0018 17.9 0.0 2.6 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase DUF952 PF06108.12 EXF84804.1 - 1.1e-21 76.6 0.0 1.5e-21 76.2 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF952) PQQ PF01011.21 EXF84804.1 - 0.045 13.7 0.0 0.11 12.5 0.0 1.7 1 0 0 1 1 1 0 PQQ enzyme repeat Pkinase PF00069.25 EXF84805.1 - 3.5e-71 239.7 0.0 6.3e-71 238.8 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF84805.1 - 4.8e-49 167.0 0.0 8e-49 166.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EXF84805.1 - 5.6e-05 22.1 0.0 0.0001 21.3 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EXF84805.1 - 0.0038 16.6 0.0 0.027 13.8 0.1 2.0 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 EXF84805.1 - 0.15 11.4 0.0 0.28 10.5 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Mur_ligase_M PF08245.12 EXF84807.1 - 1.4e-05 25.2 0.3 4.3e-05 23.6 0.1 1.8 1 1 0 2 2 2 1 Mur ligase middle domain UPF0146 PF03686.13 EXF84807.1 - 0.19 11.6 0.0 0.35 10.7 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0146) Peptidase_S9 PF00326.21 EXF84810.1 - 0.02 14.4 0.0 0.09 12.2 0.0 1.9 2 0 0 2 2 2 0 Prolyl oligopeptidase family DLH PF01738.18 EXF84810.1 - 0.032 13.8 0.0 0.91 9.0 0.0 2.2 2 0 0 2 2 2 0 Dienelactone hydrolase family Hydrolase_4 PF12146.8 EXF84810.1 - 0.033 13.4 0.0 5.6 6.1 0.0 2.3 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Abhydrolase_2 PF02230.16 EXF84810.1 - 0.04 13.7 0.0 0.23 11.3 0.0 1.9 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Serglycin PF04360.12 EXF84810.1 - 0.15 12.0 1.7 0.32 10.9 1.7 1.5 1 0 0 1 1 1 0 Serglycin SR-25 PF10500.9 EXF84810.1 - 0.98 9.0 6.7 1.3 8.5 6.7 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Secretin_N_2 PF07655.13 EXF84810.1 - 1.6 9.3 7.4 2.9 8.5 7.4 1.3 1 0 0 1 1 1 0 Secretin N-terminal domain ICE2 PF08426.10 EXF84811.1 - 1.8e-158 527.9 10.1 2.1e-158 527.7 10.1 1.0 1 0 0 1 1 1 1 ICE2 FA_desaturase PF00487.24 EXF84813.1 - 1.3e-20 74.4 21.6 2.9e-20 73.2 19.7 2.4 1 1 0 1 1 1 1 Fatty acid desaturase Lipid_DES PF08557.10 EXF84813.1 - 1.4e-18 66.1 0.2 2.5e-18 65.2 0.2 1.5 1 0 0 1 1 1 1 Sphingolipid Delta4-desaturase (DES) Motile_Sperm PF00635.26 EXF84814.1 - 7.9e-25 86.8 0.5 3.4e-24 84.8 0.7 2.0 1 1 1 2 2 2 1 MSP (Major sperm protein) domain ASH PF15780.5 EXF84814.1 - 0.0027 17.9 1.0 0.0051 17.0 0.1 2.0 2 0 0 2 2 2 1 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin UBA PF00627.31 EXF84815.1 - 7.5e-07 28.9 0.2 2.2e-06 27.4 0.0 2.0 2 0 0 2 2 2 1 UBA/TS-N domain UBX PF00789.20 EXF84815.1 - 3.9e-06 27.0 0.0 1.1e-05 25.6 0.0 1.8 1 0 0 1 1 1 1 UBX domain DUF1258 PF06869.12 EXF84815.1 - 0.0079 15.7 0.1 0.012 15.1 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1258) THRAP3_BCLAF1 PF15440.6 EXF84815.1 - 0.018 14.1 17.5 0.021 13.9 17.5 1.1 1 0 0 1 1 1 0 THRAP3/BCLAF1 family zf-C2H2_6 PF13912.6 EXF84815.1 - 0.03 14.3 0.3 0.058 13.4 0.3 1.4 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2_2 PF12756.7 EXF84815.1 - 0.048 14.0 0.5 0.11 12.9 0.2 1.7 1 1 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.26 EXF84815.1 - 0.07 13.6 0.4 0.14 12.7 0.4 1.5 1 0 0 1 1 1 0 Zinc finger, C2H2 type SOBP PF15279.6 EXF84815.1 - 1.6 9.3 4.4 2 9.0 4.4 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein CpXC PF14353.6 EXF84815.1 - 7 6.7 12.0 1.1e+02 2.9 11.8 2.6 1 1 0 1 1 1 0 CpXC protein Ribosomal_60s PF00428.19 EXF84816.1 - 6.6e-27 93.9 9.9 8.1e-27 93.7 9.9 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein DUF2408 PF10303.9 EXF84817.1 - 2.9e-39 134.7 6.9 2.1e-24 86.6 0.1 5.0 2 2 1 4 4 4 3 Protein of unknown function (DUF2408) Laminin_II PF06009.12 EXF84817.1 - 0.34 10.9 3.4 0.4 10.7 0.5 2.4 2 1 0 2 2 2 0 Laminin Domain II Csm1_N PF18504.1 EXF84817.1 - 0.39 11.1 6.5 4.2 7.8 0.3 3.9 4 0 0 4 4 4 0 Csm1 N-terminal domain Spc24 PF08286.11 EXF84817.1 - 5.1 7.4 5.8 3 8.1 0.6 3.1 2 1 1 3 3 3 0 Spc24 subunit of Ndc80 AMP-binding PF00501.28 EXF84819.1 - 4e-85 286.0 0.0 4.7e-85 285.7 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EXF84819.1 - 2e-18 67.1 0.0 5.2e-18 65.8 0.0 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain GH3 PF03321.13 EXF84819.1 - 0.00016 20.7 0.0 0.0015 17.5 0.0 2.0 2 0 0 2 2 2 1 GH3 auxin-responsive promoter RTX_C PF08339.10 EXF84819.1 - 0.05 13.7 0.0 0.1 12.6 0.0 1.5 1 0 0 1 1 1 0 RTX C-terminal domain G-patch PF01585.23 EXF84820.1 - 1.1e-12 47.6 0.2 2.5e-12 46.5 0.2 1.6 1 0 0 1 1 1 1 G-patch domain RRM_1 PF00076.22 EXF84820.1 - 3.8e-05 23.4 0.1 7.8e-05 22.4 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Mitofilin PF09731.9 EXF84820.1 - 0.87 8.4 2.8 1.5 7.6 2.8 1.3 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Recep_L_domain PF01030.24 EXF84821.1 - 0.028 14.6 6.1 0.14 12.3 0.1 4.1 1 1 2 3 3 3 0 Receptor L domain HhH-GPD PF00730.25 EXF84822.1 - 4.8e-14 52.7 0.0 1e-13 51.7 0.0 1.6 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein TerB_C PF15615.6 EXF84822.1 - 0.076 13.3 1.0 0.15 12.3 1.0 1.4 1 0 0 1 1 1 0 TerB-C domain K_channel_TID PF07941.11 EXF84822.1 - 0.2 12.1 3.6 0.11 13.0 1.0 1.9 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain Anp1 PF03452.14 EXF84823.1 - 6.3e-105 350.3 0.0 7.7e-105 350.1 0.0 1.1 1 0 0 1 1 1 1 Anp1 UCR_14kD PF02271.16 EXF84824.1 - 1.3e-43 147.0 0.1 1.5e-43 146.8 0.1 1.1 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase complex 14kD subunit Mito_carr PF00153.27 EXF84825.1 - 4.8e-65 215.5 1.0 6.8e-22 77.2 0.0 3.3 2 1 1 3 3 3 3 Mitochondrial carrier protein HET PF06985.11 EXF84826.1 - 2.3e-12 47.5 5.4 3.4e-09 37.2 2.0 2.6 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) AhpC-TSA PF00578.21 EXF84827.1 - 4.9e-25 87.8 0.0 8.2e-25 87.1 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EXF84827.1 - 3.9e-15 55.9 0.0 5.7e-15 55.3 0.0 1.3 1 0 0 1 1 1 1 Redoxin AhpC-TSA_2 PF13911.6 EXF84827.1 - 0.00028 21.0 0.0 0.0023 18.0 0.0 2.0 1 1 1 2 2 2 1 AhpC/TSA antioxidant enzyme CI-B14_5a PF07347.12 EXF84828.1 - 0.09 12.7 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a) DUF505 PF04458.12 EXF84828.1 - 0.16 10.3 0.0 0.97 7.7 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF505) adh_short_C2 PF13561.6 EXF84829.1 - 2e-46 158.5 0.2 1.4e-41 142.6 0.0 2.2 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF84829.1 - 7e-44 149.6 0.1 1e-43 149.1 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EXF84829.1 - 3.5e-15 56.4 0.0 5.6e-15 55.7 0.0 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EXF84829.1 - 0.00035 20.1 0.1 0.0028 17.1 0.1 2.1 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF1776 PF08643.10 EXF84829.1 - 0.063 12.6 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) Acetyltransf_1 PF00583.25 EXF84830.1 - 5.6e-12 45.9 0.0 1e-11 45.1 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EXF84830.1 - 1.1e-06 28.6 0.1 2e-06 27.8 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EXF84830.1 - 3.9e-06 26.7 0.1 7e-06 25.9 0.1 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_7 PF13508.7 EXF84830.1 - 5.6e-06 26.7 0.0 1.1e-05 25.8 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EXF84830.1 - 0.019 15.1 0.1 0.035 14.2 0.1 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain SOGA PF11365.8 EXF84831.1 - 0.024 15.7 0.2 0.054 14.6 0.2 1.5 1 1 0 1 1 1 0 Protein SOGA Spectrin PF00435.21 EXF84831.1 - 0.042 14.4 1.5 3.2 8.3 0.0 2.1 2 0 0 2 2 2 0 Spectrin repeat DUF4407 PF14362.6 EXF84831.1 - 0.19 11.0 0.1 0.25 10.7 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) YabA PF06156.13 EXF84831.1 - 0.57 10.8 3.2 6.2 7.5 0.2 2.1 2 0 0 2 2 2 0 Initiation control protein YabA DivIC PF04977.15 EXF84831.1 - 0.79 9.5 3.3 1.7 8.5 0.5 2.0 2 0 0 2 2 2 0 Septum formation initiator DUF4646 PF15496.6 EXF84832.1 - 0.00031 21.4 0.1 1.3 9.7 0.0 2.7 3 0 0 3 3 3 2 Domain of unknown function (DUF4646) IF-2B PF01008.17 EXF84833.1 - 4.5e-41 140.9 0.0 1.5e-40 139.2 0.0 1.7 1 1 0 1 1 1 1 Initiation factor 2 subunit family NIF PF03031.18 EXF84834.1 - 2.4e-55 186.6 0.0 3.6e-55 186.0 0.0 1.3 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase DUF1761 PF08570.10 EXF84835.1 - 3.2e-23 82.3 1.7 4.9e-23 81.7 0.5 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF1761) Ribosomal_L7Ae PF01248.26 EXF84836.1 - 5.3e-22 77.4 0.5 2.3e-21 75.3 0.5 2.0 1 1 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family SAPS PF04499.15 EXF84836.1 - 0.44 9.3 3.6 0.22 10.2 0.1 1.8 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein UcrQ PF02939.16 EXF84837.1 - 8.3e-38 128.2 0.6 9.7e-38 128.0 0.6 1.1 1 0 0 1 1 1 1 UcrQ family Band_7 PF01145.25 EXF84838.1 - 1.1e-24 87.4 7.5 2.2e-24 86.4 7.5 1.5 1 1 0 1 1 1 1 SPFH domain / Band 7 family YdfA_immunity PF12127.8 EXF84838.1 - 0.00083 18.5 5.8 0.0011 18.1 5.8 1.2 1 0 0 1 1 1 1 SigmaW regulon antibacterial DUF3103 PF11301.8 EXF84838.1 - 0.02 13.7 0.2 0.038 12.8 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3103) PknG_rubred PF16919.5 EXF84838.1 - 0.11 12.7 0.1 0.19 11.9 0.1 1.3 1 0 0 1 1 1 0 Protein kinase G rubredoxin domain Atg14 PF10186.9 EXF84838.1 - 0.17 10.9 1.1 0.24 10.4 1.1 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF676 PF05057.14 EXF84840.1 - 1.9e-51 174.7 0.0 3e-51 174.0 0.0 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Palm_thioest PF02089.15 EXF84840.1 - 1.2e-05 25.3 0.0 1.9e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 Palmitoyl protein thioesterase PGAP1 PF07819.13 EXF84840.1 - 3e-05 23.9 0.0 0.00037 20.3 0.0 2.2 1 1 0 1 1 1 1 PGAP1-like protein Abhydrolase_6 PF12697.7 EXF84840.1 - 9.6e-05 23.1 0.1 0.00097 19.8 0.0 2.1 1 1 1 2 2 2 1 Alpha/beta hydrolase family Lipase_3 PF01764.25 EXF84840.1 - 0.029 14.3 0.0 0.054 13.4 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) LolA_like PF17131.4 EXF84840.1 - 0.038 13.7 0.0 0.066 13.0 0.0 1.3 1 0 0 1 1 1 0 Outer membrane lipoprotein-sorting protein HhH-GPD PF00730.25 EXF84841.1 - 7.2e-17 61.8 0.0 1.3e-16 61.0 0.0 1.4 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 EXF84841.1 - 1.2e-08 34.4 0.0 3.2e-08 33.0 0.0 1.8 1 0 0 1 1 1 1 Helix-hairpin-helix motif ApbE PF02424.15 EXF84841.1 - 0.026 14.0 0.0 0.06 12.9 0.0 1.5 1 0 0 1 1 1 0 ApbE family zf-AN1 PF01428.16 EXF84842.1 - 1.2e-12 47.8 5.4 1.2e-12 47.8 5.4 1.6 1 1 0 1 1 1 1 AN1-like Zinc finger Transp_Tc5_C PF04236.15 EXF84842.1 - 1.2 9.5 7.7 0.57 10.6 5.6 1.5 2 0 0 2 2 2 0 Tc5 transposase C-terminal domain Ldl_recept_a PF00057.18 EXF84842.1 - 6.1 7.1 12.4 1.6 9.0 7.2 2.4 2 1 0 2 2 2 0 Low-density lipoprotein receptor domain class A ADH_N PF08240.12 EXF84843.1 - 1e-25 89.7 3.0 1e-25 89.7 3.0 2.1 3 0 0 3 3 3 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EXF84843.1 - 2e-18 66.6 0.4 3.7e-18 65.8 0.4 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EXF84843.1 - 0.0026 17.3 0.1 0.0099 15.4 0.1 1.8 1 1 0 1 1 1 1 Glucose dehydrogenase C-terminus Sacchrp_dh_NADP PF03435.18 EXF84843.1 - 0.01 16.1 0.1 0.019 15.2 0.1 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain AlaDh_PNT_C PF01262.21 EXF84843.1 - 0.024 14.0 0.4 0.041 13.2 0.4 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain UDPG_MGDP_dh_N PF03721.14 EXF84843.1 - 0.084 12.4 0.1 0.15 11.6 0.1 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Nucleopor_Nup85 PF07575.13 EXF84844.1 - 4.6e-17 61.8 0.0 3.6e-11 42.4 0.0 2.8 2 1 0 2 2 2 2 Nup85 Nucleoporin TFIIA PF03153.13 EXF84844.1 - 0.048 13.7 2.2 0.077 13.0 2.2 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF2457 PF10446.9 EXF84844.1 - 1.2 8.2 17.6 2 7.5 17.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) HNH PF01844.23 EXF84845.1 - 0.00041 20.5 3.3 0.00091 19.3 3.3 1.6 1 0 0 1 1 1 1 HNH endonuclease CDC45 PF02724.14 EXF84845.1 - 4.5 5.4 17.7 4.5 5.4 15.9 1.8 2 0 0 2 2 2 0 CDC45-like protein GATase PF00117.28 EXF84846.1 - 0.042 13.6 0.0 0.06 13.1 0.0 1.3 1 0 0 1 1 1 0 Glutamine amidotransferase class-I GATase_3 PF07685.14 EXF84846.1 - 0.11 12.1 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain HET PF06985.11 EXF84848.1 - 3.7e-09 37.1 7.9 1.8e-08 34.9 0.3 2.7 2 1 1 3 3 3 2 Heterokaryon incompatibility protein (HET) VASt PF16016.5 EXF84848.1 - 0.04 14.3 0.1 0.65 10.4 0.1 2.4 1 1 0 1 1 1 0 VAD1 Analog of StAR-related lipid transfer domain MFS_1 PF07690.16 EXF84849.1 - 5.2e-35 121.0 24.6 6.6e-35 120.7 24.6 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_4 PF06779.14 EXF84849.1 - 8.2e-07 28.6 2.3 8.2e-07 28.6 2.3 1.6 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB Mito_carr PF00153.27 EXF84850.1 - 1.1e-43 147.1 7.3 4.9e-15 55.2 0.2 4.1 4 0 0 4 4 4 4 Mitochondrial carrier protein Fungal_trans PF04082.18 EXF84851.1 - 3.9e-13 49.0 0.0 5.5e-13 48.6 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF84851.1 - 2.2e-11 43.7 9.1 3.5e-11 43.0 9.1 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PrpF PF04303.13 EXF84852.1 - 1.4e-93 313.9 0.9 2.2e-84 283.6 0.2 2.0 2 0 0 2 2 2 2 PrpF protein Translin PF01997.16 EXF84853.1 - 1.5e-49 168.8 0.0 1.8e-49 168.5 0.0 1.0 1 0 0 1 1 1 1 Translin family DUF1664 PF07889.12 EXF84853.1 - 0.036 14.1 0.5 0.96 9.5 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) ERG4_ERG24 PF01222.17 EXF84854.1 - 1.8e-140 468.5 19.4 2.1e-140 468.3 19.4 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family ATP-synt_C PF00137.21 EXF84855.1 - 2e-34 117.7 32.9 7.6e-22 77.4 14.6 2.1 2 0 0 2 2 2 2 ATP synthase subunit C Ribosomal_L7Ae PF01248.26 EXF84856.1 - 8.2e-25 86.4 0.1 1.1e-24 86.0 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family PELOTA_1 PF15608.6 EXF84856.1 - 0.0004 20.2 0.0 0.00054 19.8 0.0 1.2 1 0 0 1 1 1 1 PELOTA RNA binding domain Syja_N PF02383.18 EXF84857.1 - 2.6e-95 319.4 0.0 3.9e-95 318.9 0.0 1.3 1 0 0 1 1 1 1 SacI homology domain hSac2 PF12456.8 EXF84857.1 - 2.9e-41 139.8 0.0 5.5e-41 138.9 0.0 1.5 1 0 0 1 1 1 1 Inositol phosphatase DUF1428 PF07237.11 EXF84857.1 - 0.15 12.4 0.3 0.57 10.5 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1428) Methyltransf_34 PF11312.8 EXF84858.1 - 3.7e-110 367.9 0.0 7.9e-110 366.9 0.0 1.5 1 1 0 1 1 1 1 Putative SAM-dependent methyltransferase DUF979 PF06166.12 EXF84858.1 - 0.02 14.1 0.6 0.049 12.8 0.2 1.7 1 1 0 2 2 2 0 Protein of unknown function (DUF979) Transketolase_N PF00456.21 EXF84859.1 - 1.8e-157 523.6 0.0 2.4e-157 523.1 0.0 1.1 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.24 EXF84859.1 - 3.4e-44 150.7 0.0 5.3e-44 150.0 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 EXF84859.1 - 2.4e-10 40.4 0.0 4.9e-10 39.4 0.0 1.5 1 0 0 1 1 1 1 Transketolase, C-terminal domain DXP_synthase_N PF13292.6 EXF84859.1 - 0.00029 20.2 0.0 0.00048 19.4 0.0 1.4 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase DUF5308 PF17233.2 EXF84860.1 - 2.9e-55 187.0 6.2 3.9e-55 186.6 6.2 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5308) UPF0524 PF15823.5 EXF84861.1 - 0.39 10.1 3.0 0.65 9.3 3.0 1.3 1 0 0 1 1 1 0 UPF0524 of C3orf70 TFIIF_alpha PF05793.12 EXF84861.1 - 7.7 5.0 12.1 9.5 4.7 12.1 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Filament PF00038.21 EXF84862.1 - 3.7e-06 26.7 14.3 3.7e-06 26.7 14.3 5.4 3 1 2 5 5 5 1 Intermediate filament protein DUF4407 PF14362.6 EXF84862.1 - 0.00029 20.3 37.5 0.00082 18.8 13.2 4.7 1 1 4 5 5 5 3 Domain of unknown function (DUF4407) Jnk-SapK_ap_N PF09744.9 EXF84862.1 - 0.0029 17.8 6.2 0.0029 17.8 6.2 5.4 4 1 2 6 6 6 1 JNK_SAPK-associated protein-1 FlxA PF14282.6 EXF84862.1 - 0.014 15.3 3.7 0.014 15.3 3.7 5.8 4 1 1 6 6 6 0 FlxA-like protein Lzipper-MIP1 PF14389.6 EXF84862.1 - 0.02 15.2 1.5 0.02 15.2 1.5 4.6 2 1 2 4 4 4 0 Leucine-zipper of ternary complex factor MIP1 ZapB PF06005.12 EXF84862.1 - 0.032 14.7 0.4 0.032 14.7 0.4 7.2 6 3 0 6 6 5 0 Cell division protein ZapB LPP PF04728.13 EXF84862.1 - 0.077 13.4 17.8 0.47 10.9 0.4 5.7 5 2 0 5 5 5 0 Lipoprotein leucine-zipper TSC22 PF01166.18 EXF84862.1 - 0.085 13.2 0.4 0.085 13.2 0.4 6.0 6 0 0 6 6 6 0 TSC-22/dip/bun family CCDC92 PF14916.6 EXF84862.1 - 0.28 11.0 0.0 0.28 11.0 0.0 4.3 5 0 0 5 5 5 0 Coiled-coil domain of unknown function Shugoshin_N PF07558.11 EXF84862.1 - 1.1 9.2 18.4 0.72 9.8 1.3 5.5 5 0 0 5 5 5 0 Shugoshin N-terminal coiled-coil region DivIC PF04977.15 EXF84862.1 - 1.7 8.5 59.3 0.038 13.7 1.9 7.7 7 1 1 8 8 8 0 Septum formation initiator TolA_bind_tri PF16331.5 EXF84862.1 - 2.5 8.3 34.6 3.3 7.8 2.8 6.4 5 1 1 6 6 6 0 TolA binding protein trimerisation Bacillus_HBL PF05791.11 EXF84862.1 - 5.9 6.7 19.6 13 5.5 1.5 4.7 2 1 1 4 4 4 0 Bacillus haemolytic enterotoxin (HBL) zf-C2H2 PF00096.26 EXF84863.1 - 0.0001 22.6 13.6 0.067 13.7 2.3 3.5 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EXF84863.1 - 0.014 16.2 10.7 3.7 8.6 1.3 3.5 3 0 0 3 3 3 0 C2H2-type zinc finger Herpes_BLRF2 PF05812.12 EXF84863.1 - 0.016 15.3 0.2 0.034 14.3 0.2 1.5 1 0 0 1 1 1 0 Herpesvirus BLRF2 protein HIP1_clath_bdg PF16515.5 EXF84863.1 - 0.032 14.8 0.4 0.069 13.8 0.4 1.4 1 0 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 zf-C2H2_aberr PF17017.5 EXF84863.1 - 0.043 14.0 0.2 0.61 10.2 0.0 2.2 2 0 0 2 2 2 0 Aberrant zinc-finger FOXP-CC PF16159.5 EXF84863.1 - 0.31 11.7 0.2 0.31 11.7 0.2 3.2 3 1 0 3 3 3 0 FOXP coiled-coil domain MFS_1 PF07690.16 EXF84864.1 - 1e-32 113.5 60.7 1.6e-28 99.7 39.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1 PF07690.16 EXF84865.1 - 3e-50 171.2 86.0 6.2e-47 160.2 55.3 2.6 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EXF84865.1 - 1.3e-30 106.4 15.3 1.4e-29 103.0 15.0 2.0 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EXF84865.1 - 1.7e-13 50.3 9.1 1.7e-13 50.3 9.1 3.1 2 1 2 4 4 4 1 Sugar (and other) transporter MFS_4 PF06779.14 EXF84865.1 - 1.1e-05 24.9 10.8 1.1e-05 24.9 10.8 3.2 2 1 1 3 3 3 1 Uncharacterised MFS-type transporter YbfB DUF3522 PF12036.8 EXF84865.1 - 0.73 10.1 5.9 0.45 10.8 0.9 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF3522) 2OG-FeII_Oxy_3 PF13640.6 EXF84866.1 - 3.2e-06 27.9 0.1 5.5e-06 27.2 0.1 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Glyco_hydro_76 PF03663.14 EXF84867.1 - 1.3e-160 534.9 12.4 1.5e-160 534.7 12.4 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 EXF84867.1 - 0.014 14.5 9.7 0.1 11.6 0.5 3.2 2 1 1 3 3 3 0 Glycosyl Hydrolase Family 88 zf-MYND PF01753.18 EXF84868.1 - 0.012 15.7 2.6 0.017 15.2 2.6 1.2 1 0 0 1 1 1 0 MYND finger Bul1_N PF04425.12 EXF84868.1 - 0.075 11.8 0.7 0.093 11.5 0.7 1.1 1 0 0 1 1 1 0 Bul1 N terminus But2 PF09792.9 EXF84869.1 - 0.00057 20.3 0.2 0.0027 18.1 0.1 2.1 1 1 1 2 2 2 1 Ubiquitin 3 binding protein But2 C-terminal domain MACPF PF01823.19 EXF84871.1 - 4.8e-05 23.5 0.0 0.0001 22.5 0.0 1.5 1 1 0 1 1 1 1 MAC/Perforin domain PI-PLC-X PF00388.19 EXF84873.1 - 5.1e-07 29.4 0.0 1.8e-06 27.6 0.0 1.9 1 1 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain GCP_N_terminal PF17681.1 EXF84873.1 - 0.072 12.7 0.0 0.1 12.2 0.0 1.3 1 0 0 1 1 1 0 Gamma tubulin complex component N-terminal ADH_zinc_N PF00107.26 EXF84874.1 - 3.2e-21 75.7 0.1 7.7e-21 74.4 0.0 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EXF84874.1 - 3.6e-21 75.1 1.8 4.5e-21 74.8 0.8 1.8 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain Glu_dehyd_C PF16912.5 EXF84874.1 - 7.2e-09 35.4 0.0 1.2e-08 34.7 0.0 1.3 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 EXF84874.1 - 0.0017 19.4 0.0 0.0038 18.3 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 EXF84874.1 - 0.018 14.3 0.2 0.04 13.2 0.2 1.5 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain adh_short_C2 PF13561.6 EXF84875.1 - 2.4e-64 217.1 0.0 2.9e-64 216.8 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF84875.1 - 1.2e-52 178.2 0.1 1.5e-52 177.9 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EXF84875.1 - 2e-10 40.9 0.0 2.8e-10 40.4 0.0 1.3 1 0 0 1 1 1 1 KR domain 3HCDH_N PF02737.18 EXF84875.1 - 0.0023 17.8 0.1 0.004 17.1 0.1 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Epimerase PF01370.21 EXF84875.1 - 0.0056 16.2 0.1 0.023 14.1 0.1 2.1 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family AdoHcyase_NAD PF00670.21 EXF84875.1 - 0.0067 16.5 0.5 0.013 15.5 0.5 1.4 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 3Beta_HSD PF01073.19 EXF84875.1 - 0.029 13.4 0.0 0.051 12.6 0.0 1.3 1 1 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family UPF0146 PF03686.13 EXF84875.1 - 0.065 13.1 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0146) TrkA_N PF02254.18 EXF84875.1 - 0.067 13.5 0.0 0.11 12.8 0.0 1.2 1 0 0 1 1 1 0 TrkA-N domain Polysacc_synt_2 PF02719.15 EXF84875.1 - 0.11 11.6 0.0 0.14 11.3 0.0 1.1 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein HET PF06985.11 EXF84876.1 - 5.3e-19 69.0 0.1 1.2e-18 67.9 0.1 1.6 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) ATP-grasp_2 PF08442.10 EXF84877.1 - 4e-46 157.1 0.0 5.8e-46 156.6 0.0 1.2 1 0 0 1 1 1 1 ATP-grasp domain Ligase_CoA PF00549.19 EXF84877.1 - 1.9e-16 60.2 1.1 3.3e-16 59.5 1.1 1.4 1 0 0 1 1 1 1 CoA-ligase ATP-grasp_5 PF13549.6 EXF84877.1 - 2.5e-09 36.9 0.0 4.2e-09 36.2 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain SIR2 PF02146.17 EXF84878.1 - 2.3e-35 122.1 0.0 1.9e-24 86.5 0.0 2.1 2 0 0 2 2 2 2 Sir2 family TPP_enzyme_M PF00205.22 EXF84878.1 - 0.11 12.2 0.0 4.7 6.9 0.0 2.4 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain Adeno_E3_14_5 PF04834.12 EXF84879.1 - 0.29 11.7 3.6 5.7 7.6 0.4 2.8 2 1 0 2 2 2 0 Early E3 14.5 kDa protein Amidohydro_1 PF01979.20 EXF84880.1 - 1.9e-41 142.5 0.0 2.3e-41 142.3 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EXF84880.1 - 2.3e-15 57.1 1.3 3.4e-09 36.7 0.1 2.5 2 1 0 2 2 2 2 Amidohydrolase family Thioredoxin_2 PF13098.6 EXF84880.1 - 0.016 15.6 0.0 0.034 14.6 0.0 1.6 1 0 0 1 1 1 0 Thioredoxin-like domain Ank_2 PF12796.7 EXF84881.1 - 1.5e-56 189.0 0.0 5.6e-10 39.7 0.0 6.5 6 0 0 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EXF84881.1 - 1.5e-45 153.0 0.3 1.7e-06 28.4 0.0 12.0 6 4 7 13 13 13 10 Ankyrin repeats (many copies) Ank_3 PF13606.6 EXF84881.1 - 6.2e-41 133.7 6.0 0.00031 20.9 0.0 15.5 17 0 0 17 17 17 9 Ankyrin repeat Ank_5 PF13857.6 EXF84881.1 - 2.7e-40 135.9 2.2 9.9e-07 28.9 0.0 10.1 7 2 2 10 10 10 8 Ankyrin repeats (many copies) Ank PF00023.30 EXF84881.1 - 3.4e-36 122.1 10.2 0.00094 19.5 0.0 14.0 14 1 0 14 14 14 9 Ankyrin repeat GMC_oxred_C PF05199.13 EXF84882.1 - 3.8e-30 105.3 0.0 6.6e-30 104.5 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_N PF00732.19 EXF84882.1 - 8.1e-27 94.4 0.0 4.5e-24 85.3 0.0 2.4 2 1 0 2 2 2 2 GMC oxidoreductase Pyr_redox_2 PF07992.14 EXF84882.1 - 0.00027 20.2 0.0 0.00094 18.5 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EXF84882.1 - 0.0015 18.7 1.7 0.0055 16.9 0.0 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 EXF84882.1 - 0.0082 15.2 0.0 0.012 14.6 0.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein FAD_binding_2 PF00890.24 EXF84882.1 - 0.01 14.9 0.0 0.021 13.9 0.0 1.5 1 0 0 1 1 1 0 FAD binding domain FAD_binding_3 PF01494.19 EXF84882.1 - 0.052 12.8 0.2 0.088 12.0 0.2 1.3 1 0 0 1 1 1 0 FAD binding domain HI0933_like PF03486.14 EXF84882.1 - 0.11 11.1 0.1 0.19 10.4 0.1 1.3 1 0 0 1 1 1 0 HI0933-like protein HHH PF00633.23 EXF84882.1 - 0.56 10.2 2.1 3.9 7.5 0.0 3.0 3 0 0 3 3 3 0 Helix-hairpin-helix motif CFEM PF05730.11 EXF84883.1 - 1.3e-11 44.4 11.6 1.9e-11 43.9 11.6 1.2 1 0 0 1 1 1 1 CFEM domain Abhydrolase_1 PF00561.20 EXF84885.1 - 9.4e-18 64.8 1.2 1e-12 48.3 0.4 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EXF84885.1 - 2.5e-13 51.2 2.0 4.3e-13 50.4 2.0 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EXF84885.1 - 1.1e-09 37.9 0.1 1.7e-09 37.3 0.1 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Ndr PF03096.14 EXF84885.1 - 0.0029 16.3 0.0 0.0042 15.8 0.0 1.1 1 0 0 1 1 1 1 Ndr family EHN PF06441.12 EXF84885.1 - 0.0052 17.1 0.1 0.017 15.4 0.0 1.9 2 0 0 2 2 2 1 Epoxide hydrolase N terminus PAF-AH_p_II PF03403.13 EXF84885.1 - 0.18 10.3 0.0 0.33 9.4 0.0 1.4 1 0 0 1 1 1 0 Platelet-activating factor acetylhydrolase, isoform II DIOX_N PF14226.6 EXF84886.1 - 1.4e-26 93.6 0.0 2.1e-26 93.0 0.0 1.2 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EXF84886.1 - 1.3e-18 67.4 0.0 2.2e-18 66.6 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Zn_clus PF00172.18 EXF84887.1 - 0.071 13.3 7.1 0.14 12.4 7.1 1.4 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain FUSC PF04632.12 EXF84887.1 - 0.14 10.7 2.6 0.19 10.2 2.6 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family zf-C2H2_4 PF13894.6 EXF84888.1 - 1.1e-05 25.8 5.0 0.11 13.4 1.2 2.9 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_2 PF12756.7 EXF84888.1 - 0.00065 20.0 6.2 0.056 13.8 2.2 2.7 1 1 1 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.8 EXF84888.1 - 0.032 14.5 1.7 2.3 8.6 0.5 3.3 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zinc_ribbon_9 PF14369.6 EXF84888.1 - 0.33 11.2 2.9 1.5 9.1 0.4 2.5 2 0 0 2 2 2 0 zinc-ribbon zf-C2HC_2 PF13913.6 EXF84888.1 - 0.88 9.5 7.9 0.32 10.9 2.4 2.4 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf-C2H2 PF00096.26 EXF84888.1 - 1.1 9.8 10.6 1.2 9.7 1.2 3.3 4 0 0 4 4 4 0 Zinc finger, C2H2 type OmpH PF03938.14 EXF84888.1 - 1.2 9.5 15.5 5.7 7.3 2.6 2.4 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Annexin PF00191.20 EXF84889.1 - 8.4e-71 234.0 3.9 9.1e-19 67.3 0.2 4.3 4 0 0 4 4 4 4 Annexin Acetyltransf_11 PF13720.6 EXF84889.1 - 0.002 18.5 1.6 13 6.3 0.0 4.0 4 0 0 4 4 4 1 Udp N-acetylglucosamine O-acyltransferase; Domain 2 DUF3574 PF12098.8 EXF84889.1 - 0.0086 15.9 1.0 4 7.3 0.1 3.7 4 0 0 4 4 4 1 Protein of unknown function (DUF3574) Minor_tail_Z PF06763.11 EXF84889.1 - 0.0099 15.7 0.4 0.99 9.2 0.2 2.4 2 0 0 2 2 2 1 Prophage minor tail protein Z (GPZ) YqbF PF14553.6 EXF84889.1 - 0.041 13.7 0.8 8 6.4 0.0 3.0 3 0 0 3 3 3 0 YqbF, hypothetical protein domain DUF2255 PF10012.9 EXF84889.1 - 0.05 13.8 1.0 11 6.3 0.0 3.4 4 0 0 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2255) Myb_DNA-bind_7 PF15963.5 EXF84889.1 - 0.081 12.8 1.5 1.7 8.6 0.1 2.8 3 0 0 3 3 3 0 Myb DNA-binding like Vps35 PF03635.17 EXF84894.1 - 0 1024.9 0.0 0 1024.8 0.0 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 TFR_dimer PF04253.15 EXF84895.1 - 4.6e-30 104.2 0.0 8.4e-30 103.4 0.0 1.5 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.17 EXF84895.1 - 8.8e-16 58.2 0.0 1.7e-15 57.3 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 EXF84895.1 - 2.4e-13 49.9 0.3 5.3e-13 48.8 0.3 1.6 1 0 0 1 1 1 1 PA domain SP_C-Propep PF08999.10 EXF84895.1 - 0.11 12.3 0.0 0.26 11.1 0.0 1.6 1 0 0 1 1 1 0 Surfactant protein C, N terminal propeptide Peptidase_C48 PF02902.19 EXF84896.1 - 1.3e-18 67.7 0.0 2.6e-18 66.7 0.0 1.5 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain FAD_binding_3 PF01494.19 EXF84897.1 - 6.8e-76 255.8 0.0 1.4e-75 254.8 0.0 1.5 2 0 0 2 2 2 1 FAD binding domain Phe_hydrox_dim PF07976.12 EXF84897.1 - 6.3e-41 140.2 0.1 1.1e-40 139.3 0.1 1.4 1 0 0 1 1 1 1 Phenol hydroxylase, C-terminal dimerisation domain Pyr_redox_2 PF07992.14 EXF84897.1 - 0.00044 19.6 0.0 0.016 14.5 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EXF84897.1 - 0.001 19.6 0.0 0.0052 17.3 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EXF84897.1 - 0.027 14.7 0.0 0.07 13.4 0.0 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EXF84897.1 - 0.037 13.6 0.9 2.9 7.4 0.2 2.3 1 1 0 2 2 2 0 FAD dependent oxidoreductase XdhC_C PF13478.6 EXF84897.1 - 0.038 14.5 0.0 0.078 13.5 0.0 1.5 1 0 0 1 1 1 0 XdhC Rossmann domain HI0933_like PF03486.14 EXF84897.1 - 0.052 12.2 0.0 0.09 11.5 0.0 1.3 1 0 0 1 1 1 0 HI0933-like protein UDPG_MGDP_dh_N PF03721.14 EXF84897.1 - 0.099 12.2 0.0 0.32 10.5 0.0 1.8 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Thi4 PF01946.17 EXF84897.1 - 0.14 11.4 0.0 0.25 10.6 0.0 1.3 1 0 0 1 1 1 0 Thi4 family Lycopene_cycl PF05834.12 EXF84897.1 - 0.16 11.0 0.0 1 8.3 0.0 2.0 2 0 0 2 2 2 0 Lycopene cyclase protein MTCP1 PF08991.10 EXF84898.1 - 0.024 14.9 0.1 0.039 14.2 0.1 1.3 1 0 0 1 1 1 0 Mature-T-Cell Proliferation I type Rick_17kDa_Anti PF05433.15 EXF84900.1 - 1.4e-06 28.0 2.3 0.003 17.4 0.1 2.4 2 0 0 2 2 2 2 Glycine zipper 2TM domain Gly-zipper_Omp PF13488.6 EXF84900.1 - 0.0019 18.2 0.9 0.46 10.5 0.0 2.3 2 0 0 2 2 2 2 Glycine zipper MFS_1 PF07690.16 EXF84901.1 - 6.8e-33 114.0 56.7 9.3e-24 84.0 28.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF3681 PF12442.8 EXF84901.1 - 0.058 13.9 0.8 0.058 13.9 0.8 4.0 2 2 1 3 3 3 0 Protein of unknown function (DUF3681) LCM PF04072.14 EXF84902.1 - 1.6e-19 70.6 0.0 2.3e-19 70.1 0.0 1.2 1 0 0 1 1 1 1 Leucine carboxyl methyltransferase Kelch_4 PF13418.6 EXF84902.1 - 3.5e-06 26.9 2.5 6.8e-06 26.0 0.0 2.7 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_3 PF13415.6 EXF84902.1 - 0.0054 17.0 0.0 1.3 9.4 0.0 3.4 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_6 PF13964.6 EXF84902.1 - 0.089 13.1 0.5 16 6.0 0.0 3.5 3 0 0 3 3 3 0 Kelch motif WD40 PF00400.32 EXF84903.1 - 0.0012 19.6 1.5 0.51 11.3 0.0 4.2 5 1 0 5 5 5 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EXF84903.1 - 0.0022 18.2 0.0 0.6 10.4 0.0 3.8 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Hira PF07569.11 EXF84903.1 - 0.065 12.9 0.0 0.77 9.4 0.0 2.3 2 0 0 2 2 2 0 TUP1-like enhancer of split DSPc PF00782.20 EXF84904.1 - 1e-24 86.9 0.0 5.4e-19 68.3 0.0 2.3 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EXF84904.1 - 0.0012 18.4 0.0 0.0093 15.5 0.0 2.0 2 0 0 2 2 2 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 EXF84904.1 - 0.11 12.6 0.1 0.45 10.6 0.1 2.0 3 0 0 3 3 3 0 Inositol hexakisphosphate DDHD PF02862.17 EXF84905.1 - 1.8e-24 87.2 0.0 3.8e-12 46.8 0.0 3.3 2 1 0 3 3 3 2 DDHD domain DEAD_2 PF06733.15 EXF84906.1 - 3.1e-58 196.3 0.4 7.2e-58 195.1 0.4 1.6 1 0 0 1 1 1 1 DEAD_2 HBB PF06777.11 EXF84906.1 - 3.6e-49 167.1 1.1 5.4e-44 150.2 0.3 2.5 2 0 0 2 2 2 2 Helical and beta-bridge domain Helicase_C_2 PF13307.6 EXF84906.1 - 1.3e-43 149.2 0.0 4.9e-43 147.3 0.0 2.0 2 0 0 2 2 2 1 Helicase C-terminal domain ResIII PF04851.15 EXF84906.1 - 7.4e-05 22.8 0.1 0.0018 18.3 0.1 2.3 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EXF84906.1 - 0.00022 21.1 0.0 0.042 13.6 0.0 2.4 2 0 0 2 2 2 1 DEAD/DEAH box helicase SNF2_N PF00176.23 EXF84906.1 - 0.0032 16.2 0.0 0.048 12.4 0.0 2.2 1 1 0 1 1 1 1 SNF2 family N-terminal domain AAA_22 PF13401.6 EXF84906.1 - 0.018 15.3 0.2 1.7 8.9 0.0 2.6 2 0 0 2 2 2 0 AAA domain DUF2075 PF09848.9 EXF84906.1 - 0.03 13.6 0.5 1.1 8.4 0.0 2.5 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2075) Stomoxyn PF11585.8 EXF84906.1 - 0.068 13.2 0.2 0.16 12.0 0.2 1.6 1 0 0 1 1 1 0 Insect antimicrobial peptide, stomoxyn PhoH PF02562.16 EXF84906.1 - 0.076 12.5 0.0 4.6 6.6 0.0 2.5 2 0 0 2 2 2 0 PhoH-like protein AAA_11 PF13086.6 EXF84906.1 - 0.39 10.4 1.5 1.6 8.5 1.5 1.9 1 1 0 1 1 1 0 AAA domain GST_C_2 PF13410.6 EXF84907.1 - 1.5e-05 24.9 0.0 3.8e-05 23.6 0.0 1.6 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EXF84907.1 - 3.4e-05 24.1 0.0 0.0001 22.6 0.0 1.8 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EXF84907.1 - 4.9e-05 23.7 0.0 0.00011 22.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EXF84907.1 - 0.00019 21.6 0.0 0.00036 20.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 EXF84907.1 - 0.00028 21.1 0.1 0.00067 19.9 0.1 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EXF84907.1 - 0.025 14.8 0.0 0.049 13.8 0.0 1.5 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Polyketide_cyc2 PF10604.9 EXF84909.1 - 0.00047 20.5 0.0 0.00077 19.7 0.0 1.4 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc PF03364.20 EXF84909.1 - 0.015 15.5 0.0 0.027 14.7 0.0 1.4 1 0 0 1 1 1 0 Polyketide cyclase / dehydrase and lipid transport WSC PF01822.19 EXF84912.1 - 1.2e-69 230.5 58.3 6.6e-19 67.9 9.2 5.0 4 0 0 4 4 4 4 WSC domain Pec_lyase_C PF00544.19 EXF84913.1 - 5.4e-18 65.4 18.5 6.2e-18 65.2 14.2 2.5 2 1 0 2 2 2 1 Pectate lyase Beta_helix PF13229.6 EXF84913.1 - 3.7e-06 26.9 28.5 2e-05 24.5 13.8 2.3 1 1 1 2 2 2 2 Right handed beta helix region FAD_binding_3 PF01494.19 EXF84913.1 - 0.056 12.7 2.1 1.1 8.4 0.5 2.1 1 1 0 2 2 2 0 FAD binding domain CBM-like PF14683.6 EXF84914.1 - 4.7e-39 133.9 0.9 6.8e-38 130.1 0.3 2.5 2 0 0 2 2 2 1 Polysaccharide lyase family 4, domain III fn3_3 PF14686.6 EXF84914.1 - 4.8e-11 42.3 1.2 1.8e-10 40.5 1.2 2.1 1 0 0 1 1 1 1 Polysaccharide lyase family 4, domain II CarboxypepD_reg PF13620.6 EXF84914.1 - 8.6e-09 35.6 1.9 8.6e-09 35.6 1.9 3.0 4 0 0 4 4 4 1 Carboxypeptidase regulatory-like domain SdrD_B PF17210.3 EXF84914.1 - 0.0094 16.2 1.2 0.033 14.4 1.1 2.0 2 0 0 2 2 2 1 SdrD B-like domain CarbopepD_reg_2 PF13715.6 EXF84914.1 - 0.03 14.3 2.9 0.25 11.4 2.1 2.8 2 1 0 2 2 2 0 CarboxypepD_reg-like domain AAA PF00004.29 EXF84915.1 - 3e-08 34.2 0.1 5.6e-08 33.3 0.1 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) MFS_1 PF07690.16 EXF84917.1 - 6.5e-35 120.7 23.3 9.1e-35 120.2 23.3 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Fungal_trans PF04082.18 EXF84918.1 - 4.9e-19 68.4 0.0 1.6e-18 66.7 0.0 1.7 1 1 0 1 1 1 1 Fungal specific transcription factor domain Hydantoinase_B PF02538.14 EXF84919.1 - 5.9e-210 698.1 0.6 7.6e-210 697.7 0.6 1.1 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Hydantoinase_A PF01968.18 EXF84919.1 - 4.2e-103 344.6 0.5 1e-102 343.3 0.1 1.8 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.13 EXF84919.1 - 7.1e-60 201.8 2.7 5.2e-59 198.9 0.1 2.4 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase N-terminal region DUF2306 PF10067.9 EXF84920.1 - 1.2e-17 64.5 10.6 2.6e-17 63.4 10.6 1.5 1 0 0 1 1 1 1 Predicted membrane protein (DUF2306) DUF373 PF04123.13 EXF84920.1 - 0.13 11.7 2.3 0.16 11.4 2.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF373) Zn_clus PF00172.18 EXF84921.1 - 7.7e-07 29.1 12.1 1.6e-06 28.1 12.1 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EXF84921.1 - 0.051 12.4 0.0 0.08 11.7 0.0 1.2 1 0 0 1 1 1 0 Fungal specific transcription factor domain Fasciclin PF02469.22 EXF84922.1 - 2.7e-34 118.1 0.0 7.7e-20 71.4 0.0 2.3 2 0 0 2 2 2 2 Fasciclin domain Vint PF14623.6 EXF84923.1 - 1.8e-65 219.8 0.0 3.1e-65 219.1 0.0 1.4 1 0 0 1 1 1 1 Hint-domain Vwaint PF14624.6 EXF84923.1 - 1.2e-28 99.1 0.0 2.1e-28 98.3 0.0 1.4 1 0 0 1 1 1 1 VWA / Hh protein intein-like VWA PF00092.28 EXF84923.1 - 3.9e-19 69.6 0.0 9.8e-19 68.3 0.0 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 EXF84923.1 - 1.2e-13 51.6 0.0 2.9e-13 50.4 0.0 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 EXF84923.1 - 9.2e-13 48.4 0.0 5.1e-10 39.5 0.0 3.3 3 0 0 3 3 3 1 von Willebrand factor type A domain Hint_2 PF13403.6 EXF84923.1 - 0.18 12.1 0.2 0.79 10.0 0.1 2.2 2 0 0 2 2 2 0 Hint domain Peroxidase_2 PF01328.17 EXF84924.1 - 9e-49 166.5 0.2 1.2e-48 166.2 0.2 1.0 1 0 0 1 1 1 1 Peroxidase, family 2 Kelch_3 PF13415.6 EXF84926.1 - 1.2e-31 108.3 5.6 5.4e-06 26.6 0.0 6.5 6 1 1 7 7 7 6 Galactose oxidase, central domain Kelch_4 PF13418.6 EXF84926.1 - 2.4e-31 107.5 0.9 6.1e-13 48.6 0.0 6.2 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_1 PF01344.25 EXF84926.1 - 1.1e-17 63.3 0.9 0.0086 15.6 0.0 6.5 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 EXF84926.1 - 9e-15 54.4 1.3 0.0013 19.0 0.1 6.5 5 1 1 6 6 6 5 Kelch motif Kelch_5 PF13854.6 EXF84926.1 - 6.5e-10 38.8 5.5 0.8 9.8 0.1 5.6 6 0 0 6 6 6 4 Kelch motif Kelch_2 PF07646.15 EXF84926.1 - 2e-09 37.0 0.3 1.7 8.7 0.0 5.8 6 0 0 6 6 6 4 Kelch motif Acetyltransf_7 PF13508.7 EXF84927.1 - 1.1e-05 25.7 0.0 3.5e-05 24.2 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EXF84927.1 - 0.0005 20.3 0.2 0.049 13.9 0.2 3.1 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EXF84927.1 - 0.0005 20.0 0.0 0.31 11.0 0.0 2.3 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain FR47 PF08445.10 EXF84927.1 - 0.038 14.0 0.0 1.5 8.9 0.0 2.2 2 0 0 2 2 2 0 FR47-like protein FAA_hydrolase_N PF09298.11 EXF84928.1 - 0.019 15.1 0.1 0.037 14.2 0.1 1.4 1 0 0 1 1 1 0 Fumarylacetoacetase N-terminal F-box-like PF12937.7 EXF84929.1 - 0.00012 21.9 0.0 0.00033 20.5 0.0 1.8 1 0 0 1 1 1 1 F-box-like LRR_8 PF13855.6 EXF84929.1 - 0.34 10.7 2.1 0.73 9.6 0.0 2.6 4 0 0 4 4 4 0 Leucine rich repeat DUF1989 PF09347.10 EXF84931.1 - 5.5e-64 214.8 0.0 6.9e-64 214.5 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1989) PH_6 PF15406.6 EXF84933.1 - 0.01 16.1 0.0 0.012 15.8 0.0 1.1 1 0 0 1 1 1 1 Pleckstrin homology domain RRM_1 PF00076.22 EXF84933.1 - 0.11 12.3 0.0 0.15 11.9 0.0 1.2 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) adh_short PF00106.25 EXF84934.1 - 1.6e-18 66.9 0.0 1.1e-12 47.8 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EXF84934.1 - 2.2e-08 33.9 0.0 0.00043 19.9 0.0 2.2 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF84934.1 - 0.00079 19.4 0.0 0.0013 18.7 0.0 1.3 1 0 0 1 1 1 1 KR domain Serglycin PF04360.12 EXF84934.1 - 0.03 14.3 1.9 0.061 13.3 1.9 1.4 1 0 0 1 1 1 0 Serglycin Glyco_hydro_43 PF04616.14 EXF84936.1 - 3.3e-19 69.3 0.0 4.7e-19 68.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 GH43_C2 PF17851.1 EXF84936.1 - 1.4e-11 44.5 0.0 2e-11 44.0 0.0 1.1 1 0 0 1 1 1 1 Beta xylosidase C-terminal Concanavalin A-like domain p450 PF00067.22 EXF84937.1 - 1.4e-61 208.7 0.0 1.8e-61 208.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 BatA PF07584.11 EXF84937.1 - 0.031 14.7 1.4 0.08 13.3 1.4 1.7 1 0 0 1 1 1 0 Aerotolerance regulator N-terminal Terpene_synth_C PF03936.16 EXF84938.1 - 0.021 14.2 0.0 0.4 10.0 0.0 2.3 2 0 0 2 2 2 0 Terpene synthase family, metal binding domain p450 PF00067.22 EXF84939.1 - 7.9e-61 206.2 0.0 1.1e-60 205.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Propeptide_C1 PF08127.13 EXF84940.1 - 0.047 13.6 0.0 0.092 12.6 0.0 1.4 1 0 0 1 1 1 0 Peptidase family C1 propeptide peroxidase PF00141.23 EXF84941.1 - 1.2e-23 84.0 0.0 1.8e-23 83.5 0.0 1.2 1 0 0 1 1 1 1 Peroxidase Mannosyl_trans3 PF11051.8 EXF84942.1 - 1.3e-25 90.3 0.7 1.4e-16 60.7 0.1 2.1 1 1 1 2 2 2 2 Mannosyltransferase putative AMP-binding PF00501.28 EXF84943.1 - 1.7e-65 221.3 0.0 2e-65 221.0 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EXF84943.1 - 0.00011 23.1 0.0 0.00021 22.2 0.0 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Aldolase_II PF00596.21 EXF84944.1 - 3.5e-32 111.8 0.5 4.9e-32 111.4 0.5 1.2 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain SUV3_C PF12513.8 EXF84944.1 - 0.035 14.0 0.0 0.087 12.8 0.0 1.7 1 0 0 1 1 1 0 Mitochondrial degradasome RNA helicase subunit C terminal RebB PF11747.8 EXF84944.1 - 0.099 12.8 0.6 0.19 11.9 0.6 1.4 1 0 0 1 1 1 0 Killing trait AA_permease_2 PF13520.6 EXF84945.1 - 6.1e-56 190.1 51.6 8.2e-56 189.6 51.6 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EXF84945.1 - 2.2e-22 79.3 46.7 2.9e-22 78.9 46.7 1.1 1 0 0 1 1 1 1 Amino acid permease CN_hydrolase PF00795.22 EXF84946.1 - 1.3e-33 116.5 0.0 1.6e-33 116.1 0.0 1.1 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Fungal_trans_2 PF11951.8 EXF84947.1 - 4.6e-24 85.0 2.3 1.5e-23 83.2 2.3 1.7 1 1 0 1 1 1 1 Fungal specific transcription factor domain TFIID-18kDa PF02269.16 EXF84948.1 - 3.5e-25 87.8 2.5 6.9e-23 80.5 1.0 2.5 2 0 0 2 2 2 2 Transcription initiation factor IID, 18kD subunit CBFD_NFYB_HMF PF00808.23 EXF84948.1 - 0.093 13.0 1.2 9 6.7 0.3 3.0 3 0 0 3 3 3 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 EXF84948.1 - 0.76 10.3 3.2 24 5.5 0.3 2.7 3 0 0 3 3 3 0 Transcription initiation factor TFIID subunit A Abhydrolase_1 PF00561.20 EXF84949.1 - 2.2e-17 63.6 0.0 6.3e-17 62.1 0.0 1.7 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EXF84949.1 - 1.9e-14 53.5 0.0 7.5e-14 51.6 0.0 1.8 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EXF84949.1 - 7.5e-13 49.6 0.0 1.4e-12 48.7 0.0 1.4 1 1 1 2 2 2 1 Alpha/beta hydrolase family Ndr PF03096.14 EXF84949.1 - 2.4e-06 26.5 0.0 3.3e-06 26.0 0.0 1.1 1 0 0 1 1 1 1 Ndr family BAAT_C PF08840.11 EXF84949.1 - 0.00062 19.8 0.0 0.4 10.6 0.0 2.1 2 0 0 2 2 2 2 BAAT / Acyl-CoA thioester hydrolase C terminal Asp-B-Hydro_N PF05279.11 EXF84950.1 - 1 9.4 10.9 3 7.9 0.4 2.3 2 0 0 2 2 2 0 Aspartyl beta-hydroxylase N-terminal region Sec8_exocyst PF04048.14 EXF84951.1 - 0.071 13.0 0.0 0.16 11.9 0.0 1.5 1 0 0 1 1 1 0 Sec8 exocyst complex component specific domain GPI2 PF06432.11 EXF84951.1 - 0.18 11.2 0.0 0.28 10.6 0.0 1.2 1 0 0 1 1 1 0 Phosphatidylinositol N-acetylglucosaminyltransferase Pyr_redox_2 PF07992.14 EXF84952.1 - 3.3e-09 36.4 1.1 6.8e-08 32.1 1.1 2.2 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EXF84952.1 - 3.5e-08 33.6 0.4 7.7e-08 32.5 0.4 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EXF84952.1 - 7.2e-08 32.4 5.2 3e-06 27.1 2.6 2.3 1 1 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 EXF84952.1 - 2.5e-07 30.3 0.0 3.7e-07 29.7 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 EXF84952.1 - 4.2e-07 29.0 0.2 9.2e-07 27.9 0.2 1.5 1 1 0 1 1 1 1 HI0933-like protein FAD_binding_2 PF00890.24 EXF84952.1 - 7.5e-07 28.6 1.5 1.2e-06 27.9 1.5 1.2 1 0 0 1 1 1 1 FAD binding domain Amino_oxidase PF01593.24 EXF84952.1 - 1.2e-05 24.9 0.4 0.0066 15.8 0.1 2.2 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase Trp_halogenase PF04820.14 EXF84952.1 - 2.3e-05 23.4 0.1 0.0018 17.2 0.2 2.1 2 0 0 2 2 2 1 Tryptophan halogenase FAD_oxidored PF12831.7 EXF84952.1 - 7.6e-05 22.2 0.7 0.00012 21.5 0.7 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.22 EXF84952.1 - 0.00013 21.2 2.1 0.00021 20.5 2.1 1.4 1 1 0 1 1 1 1 Glucose inhibited division protein A Pyr_redox PF00070.27 EXF84952.1 - 0.00071 20.1 0.5 0.0016 19.0 0.5 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EXF84952.1 - 0.0012 18.0 0.1 0.28 10.2 0.1 2.2 2 0 0 2 2 2 2 Lycopene cyclase protein Pyr_redox_3 PF13738.6 EXF84952.1 - 0.0017 17.7 1.7 0.0028 16.9 1.1 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 EXF84952.1 - 0.0032 16.8 0.5 0.0054 16.1 0.5 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_9 PF13454.6 EXF84952.1 - 0.0057 16.7 0.9 1.5 8.8 0.1 2.3 2 0 0 2 2 2 2 FAD-NAD(P)-binding Thi4 PF01946.17 EXF84952.1 - 0.059 12.6 0.3 0.093 12.0 0.3 1.3 1 0 0 1 1 1 0 Thi4 family ApbA PF02558.16 EXF84952.1 - 0.088 12.5 0.7 0.23 11.1 0.7 1.7 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA 3HCDH_N PF02737.18 EXF84952.1 - 0.12 12.2 0.1 0.21 11.5 0.1 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_Gly3P_dh_N PF01210.23 EXF84952.1 - 0.2 11.6 0.1 0.34 10.9 0.1 1.3 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus p450 PF00067.22 EXF84953.1 - 2.2e-76 257.5 0.0 2.7e-76 257.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Glyco_hydro_92 PF07971.12 EXF84954.1 - 1.8e-142 475.5 0.1 2.2e-142 475.2 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 Glyco_hydro_92N PF17678.1 EXF84954.1 - 2.1e-53 181.7 1.5 3.7e-53 180.9 1.5 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 N-terminal domain NmrA PF05368.13 EXF84955.1 - 1.6e-27 96.6 0.1 2.7e-27 95.8 0.1 1.4 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EXF84955.1 - 4.5e-21 75.6 0.0 6.7e-21 75.0 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding DUF2000 PF09391.10 EXF84955.1 - 0.033 14.1 0.0 6.8 6.6 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2000) SAM_2 PF07647.17 EXF84955.1 - 0.098 12.8 0.0 0.23 11.6 0.0 1.6 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) Fungal_trans_2 PF11951.8 EXF84956.1 - 1.7e-23 83.1 4.8 1.4e-22 80.1 4.8 1.9 1 1 0 1 1 1 1 Fungal specific transcription factor domain NmrA PF05368.13 EXF84957.1 - 4.1e-27 95.3 0.5 5.2e-27 94.9 0.5 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EXF84957.1 - 3.5e-20 72.7 3.1 1.4e-18 67.5 0.1 2.2 1 1 1 2 2 2 2 NAD(P)H-binding Epimerase PF01370.21 EXF84957.1 - 1.5e-05 24.6 0.3 5.2e-05 22.8 0.1 1.9 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family Shikimate_DH PF01488.20 EXF84957.1 - 0.0001 22.4 0.0 0.00018 21.6 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase 3Beta_HSD PF01073.19 EXF84957.1 - 0.0021 17.1 0.4 0.0047 16.0 0.1 1.8 2 1 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family adh_short PF00106.25 EXF84957.1 - 0.0055 16.2 0.5 0.011 15.3 0.5 1.4 1 0 0 1 1 1 1 short chain dehydrogenase 2-oxoacid_dh PF00198.23 EXF84957.1 - 0.051 13.0 1.7 0.064 12.7 0.3 1.8 2 1 0 2 2 2 0 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Adeno_PV PF03910.13 EXF84957.1 - 0.064 12.0 1.6 0.18 10.4 1.4 1.7 2 0 0 2 2 2 0 Adenovirus minor core protein PV ABC2_membrane PF01061.24 EXF84959.1 - 6.2e-94 313.3 55.2 1.6e-49 168.2 20.0 3.4 4 0 0 4 4 3 2 ABC-2 type transporter ABC_tran PF00005.27 EXF84959.1 - 1.5e-35 122.7 0.0 2.9e-16 60.2 0.0 3.3 3 0 0 3 3 3 2 ABC transporter PDR_CDR PF06422.12 EXF84959.1 - 2.6e-34 117.0 12.3 7.2e-32 109.2 0.0 3.6 4 0 0 4 4 3 2 CDR ABC transporter ABC_trans_N PF14510.6 EXF84959.1 - 6.9e-18 65.0 0.1 6.9e-18 65.0 0.1 2.3 3 0 0 3 3 1 1 ABC-transporter N-terminal AAA_16 PF13191.6 EXF84959.1 - 1.7e-06 28.6 0.5 0.00095 19.6 0.1 2.8 3 0 0 3 3 2 1 AAA ATPase domain RsgA_GTPase PF03193.16 EXF84959.1 - 2.4e-06 27.5 0.1 0.00035 20.5 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase AAA_25 PF13481.6 EXF84959.1 - 9.8e-06 25.3 0.1 0.00081 19.0 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_21 PF13304.6 EXF84959.1 - 4.1e-05 23.5 0.0 1.2 8.9 0.0 3.6 4 0 0 4 4 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EXF84959.1 - 0.00029 20.5 0.9 0.035 13.8 0.1 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_18 PF13238.6 EXF84959.1 - 0.00048 20.7 0.0 0.075 13.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EXF84959.1 - 0.00058 20.0 0.1 0.19 11.9 0.0 2.9 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EXF84959.1 - 0.0034 17.7 0.4 0.82 9.9 0.1 2.8 2 0 0 2 2 2 1 AAA domain SMC_N PF02463.19 EXF84959.1 - 0.0044 16.5 0.0 2.1 7.7 0.0 3.5 3 1 0 3 3 3 1 RecF/RecN/SMC N terminal domain cobW PF02492.19 EXF84959.1 - 0.005 16.4 0.6 0.11 12.1 0.0 2.3 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.12 EXF84959.1 - 0.0092 15.9 0.0 1.7 8.5 0.0 2.6 2 0 0 2 2 2 1 NACHT domain AAA_17 PF13207.6 EXF84959.1 - 0.033 14.6 0.4 5.6 7.4 0.0 3.0 2 1 0 2 2 2 0 AAA domain AAA_23 PF13476.6 EXF84959.1 - 0.054 14.0 0.3 0.23 11.9 0.1 2.0 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 EXF84959.1 - 0.083 12.6 0.1 6.2 6.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 EXF84959.1 - 0.1 13.0 0.1 14 6.1 0.0 2.6 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 EXF84959.1 - 0.12 12.6 0.2 1.1 9.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 EXF84959.1 - 0.19 11.4 1.2 12 5.6 0.1 2.3 2 0 0 2 2 2 0 AAA domain ECF-ribofla_trS PF07155.12 EXF84959.1 - 0.82 9.6 11.2 0.13 12.3 0.2 3.3 3 0 0 3 3 3 0 ECF-type riboflavin transporter, S component VEK-30 PF12107.8 EXF84959.1 - 1 9.3 3.1 0.35 10.8 0.1 1.8 2 0 0 2 2 1 0 Plasminogen (Pg) ligand in fibrinolytic pathway Voltage_CLC PF00654.20 EXF84959.1 - 2.6 7.2 16.5 0.23 10.7 2.7 3.1 3 0 0 3 3 3 0 Voltage gated chloride channel ABC2_membrane_3 PF12698.7 EXF84959.1 - 2.6 7.1 49.9 9.4 5.2 21.0 4.0 3 2 0 3 3 3 0 ABC-2 family transporter protein MFS_1 PF07690.16 EXF84960.1 - 3.8e-41 141.2 23.0 3.8e-41 141.2 23.0 1.7 1 1 1 2 2 2 2 Major Facilitator Superfamily Ank_2 PF12796.7 EXF84961.1 - 2.3e-19 69.8 0.8 2.7e-09 37.5 0.1 2.7 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EXF84961.1 - 1.4e-15 57.1 3.7 3.6e-08 33.5 0.3 4.4 3 1 2 5 5 5 3 Ankyrin repeats (many copies) Ank PF00023.30 EXF84961.1 - 3e-15 55.9 4.9 2.8e-06 27.5 0.2 4.7 4 0 0 4 4 4 3 Ankyrin repeat Ank_4 PF13637.6 EXF84961.1 - 9e-13 48.5 0.9 0.00014 22.4 0.1 3.9 1 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EXF84961.1 - 2.2e-12 46.0 2.9 0.00065 20.0 0.1 4.7 5 0 0 5 5 5 3 Ankyrin repeat Helo_like_N PF17111.5 EXF84961.1 - 0.15 11.5 0.7 0.31 10.4 0.2 1.9 2 0 0 2 2 2 0 Fungal N-terminal domain of STAND proteins Thiolase_N PF00108.23 EXF84962.1 - 7.6e-69 232.0 2.2 1e-68 231.6 2.2 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EXF84962.1 - 1.4e-39 134.6 1.8 3.2e-39 133.4 0.6 2.1 2 0 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 EXF84962.1 - 0.0083 15.7 0.8 0.028 14.0 0.3 2.1 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain NUDIX PF00293.28 EXF84963.1 - 2.2e-05 24.5 0.0 4.3e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain WAPL PF07814.13 EXF84963.1 - 0.11 11.3 0.0 0.17 10.6 0.0 1.2 1 0 0 1 1 1 0 Wings apart-like protein regulation of heterochromatin CoA_trans PF01144.23 EXF84966.1 - 4.5e-100 333.5 3.5 7.3e-59 198.8 0.3 2.0 2 0 0 2 2 2 2 Coenzyme A transferase AcetylCoA_hyd_C PF13336.6 EXF84966.1 - 0.00015 21.7 0.2 0.00037 20.5 0.2 1.6 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase C-terminal domain Mal_decarbox_Al PF16957.5 EXF84966.1 - 0.032 12.6 0.1 0.032 12.6 0.1 1.4 2 0 0 2 2 2 0 Malonate decarboxylase, alpha subunit, transporter MFS_1 PF07690.16 EXF84967.1 - 1.7e-35 122.6 27.8 1.7e-35 122.6 27.8 1.3 2 0 0 2 2 2 1 Major Facilitator Superfamily UNC-93 PF05978.16 EXF84967.1 - 0.005 16.6 1.7 0.015 15.1 1.7 1.7 1 0 0 1 1 1 1 Ion channel regulatory protein UNC-93 Mito_carr PF00153.27 EXF84969.1 - 2.9e-46 155.3 5.0 3.3e-15 55.8 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Rrp44_CSD1 PF17216.3 EXF84970.1 - 0.28 10.9 2.9 0.43 10.3 2.2 1.6 2 0 0 2 2 2 0 Rrp44-like cold shock domain FAD_binding_3 PF01494.19 EXF84972.1 - 6.4e-18 65.1 1.0 7.1e-10 38.6 0.3 2.8 2 1 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 EXF84972.1 - 3.8e-07 30.2 0.0 8.4e-07 29.1 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EXF84972.1 - 1.4e-06 27.7 0.0 0.0038 16.5 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EXF84972.1 - 0.00018 21.2 0.0 0.00036 20.2 0.0 1.6 1 0 0 1 1 1 1 FAD dependent oxidoreductase Amino_oxidase PF01593.24 EXF84972.1 - 0.00034 20.0 0.0 0.057 12.7 0.0 2.5 3 0 0 3 3 3 1 Flavin containing amine oxidoreductase FAD_binding_2 PF00890.24 EXF84972.1 - 0.00042 19.5 0.3 0.00076 18.7 0.3 1.4 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 EXF84972.1 - 0.00082 18.2 0.0 0.0011 17.7 0.0 1.2 1 0 0 1 1 1 1 HI0933-like protein Thi4 PF01946.17 EXF84972.1 - 0.0012 18.1 0.0 0.0028 17.0 0.0 1.5 1 0 0 1 1 1 1 Thi4 family Pyr_redox PF00070.27 EXF84972.1 - 0.0063 17.0 0.0 0.023 15.2 0.0 2.0 2 0 0 2 2 1 1 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 EXF84972.1 - 0.0089 15.9 0.0 0.015 15.2 0.0 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain IlvN PF07991.12 EXF84972.1 - 0.0095 15.5 0.0 0.019 14.5 0.0 1.4 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain TrkA_N PF02254.18 EXF84972.1 - 0.013 15.7 0.0 0.031 14.5 0.0 1.6 1 0 0 1 1 1 0 TrkA-N domain Pyr_redox_3 PF13738.6 EXF84972.1 - 0.022 14.0 0.0 0.044 13.0 0.0 1.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EXF84972.1 - 0.022 13.8 1.7 0.049 12.7 0.2 2.2 2 1 0 2 2 2 0 Lycopene cyclase protein AlaDh_PNT_C PF01262.21 EXF84972.1 - 0.05 12.9 0.0 0.098 11.9 0.0 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.22 EXF84972.1 - 0.052 12.6 0.1 0.084 11.9 0.1 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A UDPG_MGDP_dh_N PF03721.14 EXF84972.1 - 0.11 12.1 0.0 0.17 11.4 0.0 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Shikimate_DH PF01488.20 EXF84972.1 - 0.13 12.3 0.0 0.25 11.4 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase NAD_binding_9 PF13454.6 EXF84972.1 - 0.13 12.2 0.1 0.5 10.3 0.1 1.9 2 0 0 2 2 2 0 FAD-NAD(P)-binding FMO-like PF00743.19 EXF84972.1 - 0.23 9.9 0.0 0.31 9.4 0.0 1.1 1 0 0 1 1 1 0 Flavin-binding monooxygenase-like TRAPPC-Trs85 PF12739.7 EXF84973.1 - 0.15 11.0 0.0 0.23 10.4 0.0 1.2 1 0 0 1 1 1 0 ER-Golgi trafficking TRAPP I complex 85 kDa subunit Glyco_hydro_76 PF03663.14 EXF84975.1 - 2.5e-143 478.0 12.5 2.9e-143 477.8 12.5 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Cu-oxidase_3 PF07732.15 EXF84979.1 - 2.6e-17 62.9 0.9 1.2e-16 60.8 0.2 2.4 3 0 0 3 3 3 1 Multicopper oxidase Cu-oxidase PF00394.22 EXF84979.1 - 1e-16 61.5 0.0 1.7e-16 60.8 0.0 1.4 1 0 0 1 1 1 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 EXF84979.1 - 8.2e-08 32.1 0.0 3.4e-05 23.6 0.0 2.5 2 0 0 2 2 2 2 Multicopper oxidase Cu-oxidase_3 PF07732.15 EXF84980.1 - 5.8e-24 84.4 2.8 2.2e-21 76.1 2.8 3.2 2 1 0 2 2 2 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 EXF84980.1 - 2.4e-20 72.6 2.3 1.8e-17 63.3 0.3 3.2 3 0 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.22 EXF84980.1 - 4.3e-16 59.4 0.0 1.2e-15 58.0 0.0 1.8 2 0 0 2 2 2 1 Multicopper oxidase Glyco_hydro_43 PF04616.14 EXF84982.1 - 1.4e-37 129.6 8.3 1.5e-37 129.5 8.3 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 Sugar_tr PF00083.24 EXF84983.1 - 1.1e-96 324.4 19.2 1.3e-96 324.2 19.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF84983.1 - 1.9e-28 99.4 43.6 1.1e-25 90.3 23.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_5 PF05631.14 EXF84983.1 - 9.8e-05 21.4 0.7 9.8e-05 21.4 0.7 1.6 2 0 0 2 2 2 1 Sugar-tranasporters, 12 TM TMEM135_C_rich PF15982.5 EXF84984.1 - 0.0045 17.6 0.2 0.0095 16.5 0.2 1.5 1 0 0 1 1 1 1 N-terminal cysteine-rich region of Transmembrane protein 135 p450 PF00067.22 EXF84987.1 - 4.2e-74 250.0 0.0 5.4e-74 249.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 DUF3074 PF11274.8 EXF84988.1 - 7.6e-47 159.7 0.1 1.2e-46 159.0 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3074) DUF1840 PF08895.11 EXF84988.1 - 0.11 12.9 0.0 0.46 10.8 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1840) DUF1635 PF07795.11 EXF84989.1 - 0.011 15.7 2.6 0.011 15.7 2.6 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1635) DUF2408 PF10303.9 EXF84989.1 - 0.016 15.7 1.2 0.04 14.5 1.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2408) HEPN_Toprim_N PF18871.1 EXF84989.1 - 0.023 14.6 0.8 0.039 13.9 0.8 1.3 1 0 0 1 1 1 0 HEPN/Toprim N-terminal domain 1 Fib_alpha PF08702.10 EXF84989.1 - 0.041 14.1 3.2 0.081 13.1 3.2 1.4 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family HOOK PF05622.12 EXF84989.1 - 0.042 12.0 6.1 0.057 11.6 6.1 1.1 1 0 0 1 1 1 0 HOOK protein UPF0242 PF06785.11 EXF84989.1 - 0.095 12.8 3.3 0.16 12.1 3.3 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Tam41_Mmp37 PF09139.11 EXF84989.1 - 0.29 10.5 0.9 0.5 9.8 0.9 1.3 1 0 0 1 1 1 0 Phosphatidate cytidylyltransferase, mitochondrial SlyX PF04102.12 EXF84989.1 - 0.33 11.6 5.1 0.33 11.6 2.5 2.4 1 1 1 2 2 2 0 SlyX CP12 PF02672.15 EXF84989.1 - 1.9 9.3 5.2 0.26 12.1 0.5 2.0 3 0 0 3 3 3 0 CP12 domain OmpH PF03938.14 EXF84989.1 - 2.2 8.6 11.2 2.1 8.7 9.4 1.9 2 1 0 2 2 2 0 Outer membrane protein (OmpH-like) TAFII55_N PF04658.13 EXF84990.1 - 2.7e-47 160.5 0.0 7.1e-47 159.1 0.0 1.7 1 0 0 1 1 1 1 TAFII55 protein conserved region DUF4602 PF15375.6 EXF84990.1 - 1.1 9.6 10.8 0.069 13.5 2.4 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4602) DUF883 PF05957.13 EXF84990.1 - 7 7.3 10.2 0.4 11.3 4.2 2.0 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) Ribosomal_L37 PF08561.10 EXF84991.1 - 7e-42 142.8 2.8 7e-42 142.8 2.8 1.8 1 1 1 2 2 2 1 Mitochondrial ribosomal protein L37 NDUFB10 PF10249.9 EXF84992.1 - 0.0014 19.2 0.0 0.0015 19.0 0.0 1.1 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase subunit 10 HWE_HK PF07536.14 EXF84992.1 - 0.11 13.2 0.0 0.17 12.6 0.0 1.2 1 0 0 1 1 1 0 HWE histidine kinase RRM_1 PF00076.22 EXF84993.1 - 2.2e-37 126.7 0.0 1.2e-17 63.5 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EXF84993.1 - 8.9e-06 25.7 0.0 0.14 12.3 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif DTHCT PF08070.11 EXF84993.1 - 0.0021 18.7 38.1 0.0021 18.7 38.1 4.1 1 1 3 4 4 4 2 DTHCT (NUC029) region DUF4140 PF13600.6 EXF84993.1 - 0.027 14.9 0.0 0.027 14.9 0.0 4.0 3 1 0 3 3 3 0 N-terminal domain of unknown function (DUF4140) Nup35_RRM_2 PF14605.6 EXF84993.1 - 0.19 11.8 0.0 20 5.3 0.0 2.4 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif stn_TNFRSF12A PF12191.8 EXF84994.1 - 0.056 13.7 0.1 0.14 12.4 0.1 1.6 1 0 0 1 1 1 0 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain WH2 PF02205.20 EXF84995.1 - 8.5e-12 44.5 2.0 1.2e-10 40.9 0.4 2.9 3 0 0 3 3 3 1 WH2 motif Dscam_C PF12355.8 EXF84996.1 - 2.3 9.2 8.2 12 6.8 1.2 2.6 2 0 0 2 2 2 0 Down syndrome cell adhesion molecule C terminal Phage_holin_3_6 PF07332.11 EXF84997.1 - 0.00012 22.1 0.1 0.00012 22.1 0.1 2.5 1 1 2 3 3 3 1 Putative Actinobacterial Holin-X, holin superfamily III 7tm_7 PF08395.12 EXF84997.1 - 0.0084 15.4 6.2 0.012 14.8 6.2 1.1 1 0 0 1 1 1 1 7tm Chemosensory receptor DUF2207 PF09972.9 EXF84997.1 - 1.8 7.2 3.4 3.6 6.2 3.4 1.4 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) Cyt_bd_oxida_II PF02322.15 EXF84997.1 - 2.5 7.4 10.3 6.3 6.1 10.3 1.5 1 1 0 1 1 1 0 Cytochrome bd terminal oxidase subunit II CHORD PF04968.12 EXF84998.1 - 2.4e-49 165.9 19.2 1.3e-25 89.9 6.3 2.2 2 0 0 2 2 2 2 CHORD CS PF04969.16 EXF84998.1 - 2.2e-12 47.8 0.1 3.2e-12 47.3 0.1 1.3 1 0 0 1 1 1 1 CS domain DUF836 PF05768.14 EXF84999.1 - 2.5e-12 47.0 0.0 3e-12 46.8 0.0 1.1 1 0 0 1 1 1 1 Glutaredoxin-like domain (DUF836) Glutaredoxin PF00462.24 EXF84999.1 - 0.00097 19.3 0.0 0.0017 18.5 0.0 1.6 1 0 0 1 1 1 1 Glutaredoxin HpcH_HpaI PF03328.14 EXF85000.1 - 2.7e-31 108.4 0.0 3.5e-31 108.1 0.0 1.1 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family SHS2_Rpb7-N PF03876.17 EXF85001.1 - 1.6e-15 57.2 0.0 2.5e-15 56.6 0.0 1.3 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 PF00575.23 EXF85001.1 - 9.7e-12 45.1 0.0 1.6e-11 44.3 0.0 1.3 1 0 0 1 1 1 1 S1 RNA binding domain DUF962 PF06127.11 EXF85002.1 - 1.6e-26 92.2 0.0 3e-26 91.3 0.0 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF962) MIG-14_Wnt-bd PF06664.12 EXF85002.1 - 0.1 11.8 0.1 0.23 10.7 0.0 1.5 2 0 0 2 2 2 0 Wnt-binding factor required for Wnt secretion Promethin PF16015.5 EXF85002.1 - 3.3 7.7 8.1 0.16 11.9 2.6 1.7 2 0 0 2 2 2 0 Promethin DUF1244 PF06844.11 EXF85004.1 - 0.22 11.7 1.1 0.5 10.6 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1244) FlxA PF14282.6 EXF85005.1 - 0.093 12.7 1.8 0.17 11.9 1.8 1.3 1 0 0 1 1 1 0 FlxA-like protein MOSC PF03473.17 EXF85007.1 - 2.4e-35 121.4 0.0 4.5e-35 120.5 0.0 1.5 1 0 0 1 1 1 1 MOSC domain Aminotran_5 PF00266.19 EXF85007.1 - 2e-23 83.0 0.0 3.2e-23 82.3 0.0 1.3 1 1 0 1 1 1 1 Aminotransferase class-V MOSC_N PF03476.16 EXF85007.1 - 2.2e-20 72.7 0.0 4e-20 71.9 0.0 1.4 1 0 0 1 1 1 1 MOSC N-terminal beta barrel domain AAA_22 PF13401.6 EXF85008.1 - 3.6e-15 56.5 0.0 1.2e-14 54.7 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EXF85008.1 - 5.1e-14 53.0 1.2 1.3e-12 48.5 0.0 3.2 2 2 0 2 2 2 1 AAA ATPase domain AAA PF00004.29 EXF85008.1 - 6.5e-11 42.8 0.0 1.9e-10 41.3 0.0 1.8 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) Cdc6_C PF09079.11 EXF85008.1 - 4.8e-07 29.7 0.2 4.4e-06 26.6 0.2 2.4 1 1 0 1 1 1 1 CDC6, C terminal winged helix domain TniB PF05621.11 EXF85008.1 - 2.4e-06 27.1 0.0 4.5e-06 26.2 0.0 1.4 1 0 0 1 1 1 1 Bacterial TniB protein AAA_lid_10 PF17872.1 EXF85008.1 - 5.6e-06 26.4 0.0 2.3e-05 24.4 0.0 2.0 2 0 0 2 2 1 1 AAA lid domain AAA_19 PF13245.6 EXF85008.1 - 1.6e-05 25.2 0.1 5.5e-05 23.5 0.0 1.9 2 0 0 2 2 2 1 AAA domain ATPase_2 PF01637.18 EXF85008.1 - 0.00024 21.1 0.0 0.00073 19.5 0.0 1.8 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_30 PF13604.6 EXF85008.1 - 0.00025 20.8 0.0 0.0011 18.8 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 EXF85008.1 - 0.0019 17.8 0.2 0.0063 16.1 0.0 1.9 2 0 0 2 2 2 1 P-loop containing dynein motor region Rad17 PF03215.15 EXF85008.1 - 0.0024 17.8 0.5 0.033 14.1 0.1 2.2 2 0 0 2 2 2 1 Rad17 P-loop domain NB-ARC PF00931.22 EXF85008.1 - 0.0029 16.8 0.0 0.0098 15.1 0.0 1.7 1 1 0 1 1 1 1 NB-ARC domain DUF815 PF05673.13 EXF85008.1 - 0.0042 16.3 0.0 0.01 15.1 0.0 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_14 PF13173.6 EXF85008.1 - 0.0067 16.5 0.0 0.015 15.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain Sigma54_activat PF00158.26 EXF85008.1 - 0.0096 15.6 0.0 0.018 14.8 0.0 1.5 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_24 PF13479.6 EXF85008.1 - 0.012 15.3 0.0 0.023 14.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain SRPRB PF09439.10 EXF85008.1 - 0.016 14.6 0.0 0.048 13.1 0.0 1.8 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit RNA_helicase PF00910.22 EXF85008.1 - 0.038 14.4 0.0 0.096 13.1 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_5 PF07728.14 EXF85008.1 - 0.039 13.9 0.0 0.15 12.1 0.0 1.9 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 EXF85008.1 - 0.046 14.3 0.0 0.11 13.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EXF85008.1 - 0.049 13.8 0.0 0.18 12.0 0.0 2.0 1 0 0 1 1 1 0 AAA domain KAP_NTPase PF07693.14 EXF85008.1 - 0.052 12.8 0.0 0.082 12.1 0.0 1.4 1 0 0 1 1 1 0 KAP family P-loop domain NACHT PF05729.12 EXF85008.1 - 0.076 12.9 0.0 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA_32 PF13654.6 EXF85008.1 - 0.13 11.0 0.3 0.25 10.1 0.0 1.5 2 0 0 2 2 2 0 AAA domain Rrf2 PF02082.20 EXF85008.1 - 0.16 12.4 0.0 0.49 10.8 0.0 1.8 1 0 0 1 1 1 0 Transcriptional regulator AAA_28 PF13521.6 EXF85008.1 - 0.31 11.3 1.3 1.8 8.8 0.0 2.6 3 0 0 3 3 3 0 AAA domain Arrestin_N PF00339.29 EXF85009.1 - 4.9e-19 68.8 0.0 3.3e-18 66.1 0.0 2.2 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 EXF85009.1 - 7.8e-06 26.4 0.1 0.00015 22.2 0.0 2.5 2 1 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain CYSTM PF12734.7 EXF85010.1 - 4.3e-13 49.3 18.5 4.3e-13 49.3 18.5 3.8 3 1 1 4 4 4 1 Cysteine-rich TM module stress tolerance Polyketide_cyc2 PF10604.9 EXF85011.1 - 0.0086 16.4 1.7 0.017 15.4 1.3 1.8 1 1 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Dabb PF07876.12 EXF85012.1 - 1.2e-10 41.9 0.0 1.7e-10 41.4 0.0 1.2 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain HATPase_c PF02518.26 EXF85013.1 - 2.3e-21 76.4 0.0 5.8e-21 75.1 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EXF85013.1 - 4.1e-17 62.4 0.9 5.8e-16 58.7 0.1 3.0 2 1 0 2 2 2 1 Response regulator receiver domain PAS_4 PF08448.10 EXF85013.1 - 1.3e-14 54.4 0.3 2.5e-05 24.5 0.0 4.4 4 1 0 4 4 4 2 PAS fold PAS_9 PF13426.7 EXF85013.1 - 7.3e-14 51.9 0.0 0.00078 19.7 0.0 3.8 3 0 0 3 3 3 3 PAS domain PAS PF00989.25 EXF85013.1 - 3e-13 49.8 0.0 0.00066 19.7 0.0 3.9 3 0 0 3 3 3 3 PAS fold HisKA PF00512.25 EXF85013.1 - 2.4e-08 33.9 0.0 1e-07 31.9 0.0 2.2 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain PAS_3 PF08447.12 EXF85013.1 - 1.6e-06 28.3 0.1 0.15 12.4 0.0 3.7 4 0 0 4 4 4 2 PAS fold PAS_8 PF13188.7 EXF85013.1 - 0.00026 20.9 0.0 1.4 9.1 0.0 3.4 3 0 0 3 3 3 2 PAS domain GAF_2 PF13185.6 EXF85013.1 - 0.007 16.7 0.0 0.29 11.4 0.0 2.6 2 0 0 2 2 2 1 GAF domain GAF_3 PF13492.6 EXF85013.1 - 0.012 15.9 0.0 0.043 14.1 0.0 2.0 2 0 0 2 2 2 0 GAF domain GAF PF01590.26 EXF85013.1 - 0.013 16.2 0.0 0.79 10.3 0.0 2.7 2 0 0 2 2 2 0 GAF domain DUF370 PF04025.12 EXF85013.1 - 0.37 10.9 1.0 1.3 9.2 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF370) Mpv17_PMP22 PF04117.12 EXF85014.1 - 5e-12 45.9 3.7 9.2e-12 45.0 0.2 2.3 2 0 0 2 2 2 1 Mpv17 / PMP22 family Methyltransf_15 PF09445.10 EXF85014.1 - 0.032 13.8 0.0 0.046 13.3 0.0 1.2 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase UCR_6-4kD PF08997.10 EXF85014.1 - 0.12 12.3 0.5 0.53 10.3 0.0 2.2 2 1 1 3 3 3 0 Ubiquinol-cytochrome C reductase complex, 6.4kD protein YIF1 PF03878.15 EXF85015.1 - 2.1e-101 338.4 0.7 2.4e-101 338.2 0.7 1.0 1 0 0 1 1 1 1 YIF1 Yip1 PF04893.17 EXF85015.1 - 0.025 14.3 11.7 0.016 14.9 9.5 1.8 1 1 1 2 2 2 0 Yip1 domain SRP-alpha_N PF04086.13 EXF85016.1 - 5.8e-90 302.2 0.0 7.7e-90 301.7 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle, alpha subunit, N-terminal SRP54 PF00448.22 EXF85016.1 - 5.3e-53 179.6 0.4 2.5e-52 177.4 0.2 2.1 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain SRP54_N PF02881.19 EXF85016.1 - 1.4e-08 34.8 0.1 4.3e-08 33.3 0.1 1.8 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain MeaB PF03308.16 EXF85016.1 - 6.9e-06 25.2 0.0 1.5e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_30 PF13604.6 EXF85016.1 - 0.00089 19.0 0.2 0.002 17.9 0.2 1.5 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 EXF85016.1 - 0.0023 18.3 0.6 0.0072 16.8 0.1 2.0 2 0 0 2 2 2 1 AAA domain cobW PF02492.19 EXF85016.1 - 0.0043 16.7 0.1 0.011 15.3 0.1 1.7 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_25 PF13481.6 EXF85016.1 - 0.0073 15.9 0.1 0.017 14.7 0.1 1.6 1 0 0 1 1 1 1 AAA domain CbiA PF01656.23 EXF85016.1 - 0.01 15.9 0.5 2 8.5 0.1 2.8 3 0 0 3 3 3 0 CobQ/CobB/MinD/ParA nucleotide binding domain MMR_HSR1 PF01926.23 EXF85016.1 - 0.028 14.5 0.3 0.13 12.3 0.3 2.1 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_24 PF13479.6 EXF85016.1 - 0.029 14.1 0.0 0.1 12.3 0.0 1.9 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 EXF85016.1 - 0.029 14.9 0.1 0.18 12.3 0.0 2.3 2 1 0 2 2 2 0 ABC transporter AAA_33 PF13671.6 EXF85016.1 - 0.04 14.1 0.0 0.095 12.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EXF85016.1 - 0.091 13.1 0.0 0.43 10.9 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain APS_kinase PF01583.20 EXF85016.1 - 0.19 11.6 0.5 0.61 10.0 0.0 2.0 2 0 0 2 2 2 0 Adenylylsulphate kinase Endotoxin_C2 PF18449.1 EXF85017.1 - 0.15 12.4 2.1 0.99 9.8 0.4 2.8 2 0 0 2 2 2 0 Delta endotoxin DUF725 PF05267.12 EXF85017.1 - 6.4 6.8 8.4 1.7 8.6 1.1 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF725) ApoO PF09769.9 EXF85017.1 - 7.3 6.6 7.8 1.6 8.7 1.4 3.0 2 0 0 2 2 2 0 Apolipoprotein O Mid2 PF04478.12 EXF85019.1 - 2.5e-05 24.2 2.0 2.5e-05 24.2 2.0 1.7 1 1 0 1 1 1 1 Mid2 like cell wall stress sensor MAP17 PF15807.5 EXF85019.1 - 0.039 14.2 0.1 0.094 12.9 0.0 1.7 2 0 0 2 2 2 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 TPR_21 PF09976.9 EXF85019.1 - 0.046 13.4 0.3 0.082 12.6 0.0 1.5 2 0 0 2 2 2 0 Tetratricopeptide repeat-like domain FeoB_associated PF12669.7 EXF85019.1 - 0.15 12.5 0.4 0.26 11.7 0.4 1.4 1 0 0 1 1 1 0 FeoB-associated Cys-rich membrane protein Amidohydro_1 PF01979.20 EXF85020.1 - 3e-16 59.7 0.0 2.2e-15 56.8 0.0 2.0 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EXF85020.1 - 0.0011 18.6 0.0 0.0024 17.4 0.0 1.5 1 1 0 1 1 1 1 Amidohydrolase family Glyco_hydro_35 PF01301.19 EXF85021.1 - 5.3e-94 315.4 0.0 7e-94 315.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 BetaGal_dom4_5 PF13364.6 EXF85021.1 - 7.7e-55 184.4 3.6 4.1e-27 95.0 0.0 3.0 3 0 0 3 3 3 2 Beta-galactosidase jelly roll domain BetaGal_dom2 PF10435.9 EXF85021.1 - 8e-55 185.5 4.0 1.4e-54 184.7 4.0 1.4 1 0 0 1 1 1 1 Beta-galactosidase, domain 2 BetaGal_dom3 PF13363.6 EXF85021.1 - 2.4e-22 78.3 0.1 4.9e-22 77.3 0.1 1.5 1 0 0 1 1 1 1 Beta-galactosidase, domain 3 SBP_bac_6 PF13343.6 EXF85022.1 - 6.1e-15 55.3 0.3 3.3e-14 52.9 0.3 1.8 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_8 PF13416.6 EXF85022.1 - 4.4e-08 33.3 0.2 6.2e-07 29.5 0.2 2.1 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_11 PF13531.6 EXF85022.1 - 5.2e-07 29.6 0.0 8.2e-07 29.0 0.0 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 EXF85022.1 - 2.4e-06 27.8 0.2 0.024 14.6 0.1 2.2 2 0 0 2 2 2 2 Bacterial extracellular solute-binding protein PAD PF03068.15 EXF85023.1 - 3.2e-125 418.2 0.0 3.8e-125 417.9 0.0 1.1 1 0 0 1 1 1 1 Protein-arginine deiminase (PAD) Fungal_trans_2 PF11951.8 EXF85024.1 - 1.6e-08 33.8 0.8 3.4e-08 32.7 0.2 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain 2OG-FeII_Oxy_3 PF13640.6 EXF85025.1 - 1.9e-07 31.9 0.0 4e-07 30.8 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily C1-set PF07654.15 EXF85026.1 - 0.24 11.8 1.0 0.89 10.0 1.0 2.0 1 0 0 1 1 1 0 Immunoglobulin C1-set domain Cupin_2 PF07883.11 EXF85028.1 - 0.0003 20.4 0.2 0.00039 20.1 0.2 1.2 1 0 0 1 1 1 1 Cupin domain Cupin_7 PF12973.7 EXF85028.1 - 0.0048 16.8 0.1 0.01 15.8 0.1 1.5 1 1 0 1 1 1 1 ChrR Cupin-like domain PI-PLC-X PF00388.19 EXF85029.1 - 1.3e-57 193.5 0.0 2.4e-57 192.6 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 EXF85029.1 - 2.4e-40 137.5 0.0 4.3e-40 136.6 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain C2 PF00168.30 EXF85029.1 - 0.0003 21.0 0.3 0.0015 18.8 0.0 2.3 3 0 0 3 3 3 1 C2 domain Cytochrome_C7 PF14522.6 EXF85030.1 - 0.0068 16.4 3.0 0.0083 16.1 3.0 1.1 1 0 0 1 1 1 1 Cytochrome c7 and related cytochrome c Gmx_para_CXXCG PF09535.10 EXF85030.1 - 0.014 14.6 3.4 0.39 9.9 0.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (Gmx_para_CXXCG) DUF2256 PF10013.9 EXF85030.1 - 1.6 8.9 7.1 9.3 6.5 0.3 3.1 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2256) Fungal_trans PF04082.18 EXF85031.1 - 7.8e-11 41.5 1.6 1.4e-10 40.7 1.6 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 EXF85031.1 - 4.9e-09 36.2 14.3 0.00058 20.2 1.4 3.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type Zn_clus PF00172.18 EXF85031.1 - 8.5e-06 25.8 12.4 8.5e-06 25.8 12.4 2.3 2 1 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-H2C2_2 PF13465.6 EXF85031.1 - 3.2e-05 24.2 3.2 3.2e-05 24.2 3.2 2.6 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_6 PF13912.6 EXF85031.1 - 0.0014 18.6 7.8 0.013 15.5 2.9 2.7 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_4 PF13894.6 EXF85031.1 - 0.0047 17.6 18.5 0.047 14.5 0.6 3.5 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EXF85031.1 - 0.062 13.6 2.6 1.6 9.1 0.7 2.6 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding F-box-like PF12937.7 EXF85032.1 - 0.018 14.9 0.0 0.067 13.1 0.0 2.0 1 0 0 1 1 1 0 F-box-like Pyrid_oxidase_2 PF13883.6 EXF85033.1 - 1.1e-40 139.4 0.0 1.5e-40 138.9 0.0 1.1 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase AF-4 PF05110.13 EXF85035.1 - 0.2 9.7 2.8 0.27 9.3 2.8 1.3 1 1 0 1 1 1 0 AF-4 proto-oncoprotein Robl_LC7 PF03259.17 EXF85036.1 - 7.3e-09 35.3 0.0 4.7e-05 23.1 0.0 2.1 2 0 0 2 2 2 2 Roadblock/LC7 domain DUF5542 PF17696.1 EXF85036.1 - 0.025 14.7 0.1 0.038 14.1 0.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5542) LAMTOR5 PF16672.5 EXF85036.1 - 0.12 12.3 0.0 0.34 10.9 0.0 1.6 2 0 0 2 2 2 0 Ragulator complex protein LAMTOR5 Ipi1_N PF12333.8 EXF85037.1 - 1.9e-29 102.3 1.9 3.8e-29 101.3 0.1 2.2 2 0 0 2 2 2 1 Rix1 complex component involved in 60S ribosome maturation TPR_20 PF14561.6 EXF85037.1 - 0.014 15.7 0.1 0.032 14.5 0.1 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat DEAD PF00270.29 EXF85038.1 - 1.8e-39 135.3 0.0 2.7e-39 134.7 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EXF85038.1 - 9.3e-27 93.6 0.0 3.1e-26 91.9 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 EXF85038.1 - 0.022 13.5 0.0 0.033 12.9 0.0 1.1 1 0 0 1 1 1 0 SNF2 family N-terminal domain Aldedh PF00171.22 EXF85039.1 - 5.7e-116 387.8 0.0 7e-116 387.5 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family PhoLip_ATPase_C PF16212.5 EXF85040.1 - 1.6e-76 257.4 27.5 1.6e-76 257.4 27.5 2.4 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EXF85040.1 - 5e-20 70.9 0.7 1.5e-19 69.4 0.7 1.8 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 EXF85040.1 - 1.4e-12 47.5 0.0 7.8e-12 45.1 0.0 2.2 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EXF85040.1 - 5.1e-12 46.5 2.5 2.5e-07 31.2 0.3 3.0 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 EXF85040.1 - 0.0019 17.8 0.3 0.0094 15.5 0.0 2.4 3 1 0 3 3 3 1 E1-E2 ATPase Hydrolase_3 PF08282.12 EXF85040.1 - 0.0034 17.2 0.9 0.0086 15.8 0.9 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase vATP-synt_E PF01991.18 EXF85042.1 - 9.1e-69 230.9 12.3 1.1e-68 230.6 12.3 1.1 1 0 0 1 1 1 1 ATP synthase (E/31 kDa) subunit Flot PF15975.5 EXF85042.1 - 0.078 13.2 0.9 0.078 13.2 0.9 2.0 1 1 1 2 2 2 0 Flotillin Mg_trans_NIPA PF05653.14 EXF85043.1 - 2.8e-18 66.0 10.9 4.9e-18 65.3 10.9 1.3 1 1 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 EXF85043.1 - 3.3e-05 24.1 13.9 0.00034 20.8 0.3 2.8 2 1 0 2 2 2 2 EamA-like transporter family PUNUT PF16913.5 EXF85043.1 - 6.9e-05 22.2 1.4 6.9e-05 22.2 1.4 2.3 1 1 1 2 2 2 1 Purine nucleobase transmembrane transport Neurensin PF14927.6 EXF85043.1 - 0.014 15.1 0.5 1.3 8.8 0.2 2.8 2 0 0 2 2 2 0 Neurensin Tetraspanin PF00335.20 EXF85044.1 - 1.7e-05 24.6 6.3 2.4e-05 24.1 6.3 1.2 1 0 0 1 1 1 1 Tetraspanin family GerA PF03323.13 EXF85044.1 - 0.093 11.2 1.8 1.7 7.0 0.5 2.2 2 0 0 2 2 2 0 Bacillus/Clostridium GerA spore germination protein E1-E2_ATPase PF00122.20 EXF85045.1 - 2.4e-39 134.7 0.2 2.4e-39 134.7 0.2 2.7 3 0 0 3 3 3 2 E1-E2 ATPase Cation_ATPase_C PF00689.21 EXF85045.1 - 1.9e-35 122.2 6.1 1.9e-35 122.2 6.1 3.0 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 EXF85045.1 - 1.4e-21 77.7 0.0 7.3e-10 39.5 0.0 3.3 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EXF85045.1 - 2.1e-11 43.3 0.0 5.4e-11 42.0 0.0 1.8 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 EXF85045.1 - 2.6e-11 43.5 0.0 5.4e-11 42.4 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) DUF2157 PF09925.9 EXF85045.1 - 0.00013 21.7 4.9 0.00023 21.0 0.0 2.9 3 0 0 3 3 3 1 Predicted membrane protein (DUF2157) Hydrolase_3 PF08282.12 EXF85045.1 - 0.00073 19.4 0.1 0.0014 18.5 0.1 1.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF3262 PF11660.8 EXF85045.1 - 1.4 9.4 8.2 5.7 7.4 0.3 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3262) DUF1218 PF06749.12 EXF85045.1 - 2.3 8.8 7.4 9.3 6.9 2.0 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF1218) DUF2207 PF09972.9 EXF85045.1 - 3.2 6.4 8.1 20 3.8 1.7 3.2 3 0 0 3 3 3 0 Predicted membrane protein (DUF2207) DUF2231 PF09990.9 EXF85045.1 - 9.3 6.7 9.9 0.1 13.0 1.0 2.4 3 0 0 3 3 3 0 Predicted membrane protein (DUF2231) TadE PF07811.12 EXF85046.1 - 0.025 14.8 2.3 0.031 14.6 0.4 2.1 2 0 0 2 2 2 0 TadE-like protein Sugar_tr PF00083.24 EXF85047.1 - 6.3e-98 328.6 24.2 7.4e-98 328.3 24.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF85047.1 - 4.9e-18 65.2 53.1 7.5e-16 58.0 28.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Trp_oprn_chp PF09534.10 EXF85047.1 - 0.068 13.0 0.3 1.3 8.8 0.1 2.4 2 0 0 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) LapA_dom PF06305.11 EXF85047.1 - 1.1 9.2 3.8 6.8 6.6 0.1 3.5 3 0 0 3 3 3 0 Lipopolysaccharide assembly protein A domain 4HBT PF03061.22 EXF85049.1 - 2e-09 37.7 0.0 2.8e-09 37.2 0.0 1.2 1 0 0 1 1 1 1 Thioesterase superfamily NmrA PF05368.13 EXF85050.1 - 1.9e-14 53.8 0.0 2.7e-14 53.3 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EXF85050.1 - 1.7e-13 50.8 0.1 4.1e-13 49.6 0.1 1.7 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EXF85050.1 - 1.6e-06 27.8 0.0 1.4e-05 24.7 0.0 2.0 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family F420_oxidored PF03807.17 EXF85050.1 - 0.0024 18.4 0.2 0.0052 17.3 0.2 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent KR PF08659.10 EXF85050.1 - 0.0028 17.6 0.2 0.0042 17.0 0.2 1.3 1 0 0 1 1 1 1 KR domain 3Beta_HSD PF01073.19 EXF85050.1 - 0.0036 16.3 0.0 0.0054 15.8 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 EXF85050.1 - 0.005 16.3 0.0 0.25 10.7 0.1 2.1 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase Sacchrp_dh_NADP PF03435.18 EXF85050.1 - 0.017 15.4 0.1 0.031 14.5 0.1 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Glyoxalase_3 PF13468.6 EXF85050.1 - 0.047 13.8 0.0 0.073 13.2 0.0 1.3 1 0 0 1 1 1 0 Glyoxalase-like domain LpxI_N PF17930.1 EXF85050.1 - 0.06 13.2 0.2 0.14 12.1 0.2 1.5 1 0 0 1 1 1 0 LpxI N-terminal domain DapB_N PF01113.20 EXF85050.1 - 0.088 12.9 1.2 0.27 11.4 1.2 1.9 1 1 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Phage_SSB PF16773.5 EXF85050.1 - 0.12 12.4 0.2 0.39 10.8 0.0 1.8 2 0 0 2 2 2 0 Lactococcus phage single-stranded DNA binding protein Polysacc_synt_2 PF02719.15 EXF85050.1 - 0.16 11.0 0.1 0.27 10.3 0.1 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Fungal_trans PF04082.18 EXF85051.1 - 1.7e-12 46.9 0.0 3.2e-12 46.0 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-LITAF-like PF10601.9 EXF85053.1 - 3.9e-17 62.3 0.2 6e-17 61.7 0.2 1.3 1 0 0 1 1 1 1 LITAF-like zinc ribbon domain Sgf11 PF08209.11 EXF85053.1 - 0.013 15.0 3.2 0.043 13.4 0.5 2.4 2 0 0 2 2 2 0 Sgf11 (transcriptional regulation protein) Zn_Tnp_IS1595 PF12760.7 EXF85053.1 - 0.038 14.0 1.3 0.36 10.9 0.1 2.3 2 0 0 2 2 2 0 Transposase zinc-ribbon domain RecR PF02132.15 EXF85053.1 - 2.4 7.8 4.6 2.7 7.6 0.1 2.7 3 0 0 3 3 3 0 RecR protein OPT PF03169.15 EXF85055.1 - 0.089 11.4 0.8 0.12 11.0 0.8 1.1 1 0 0 1 1 1 0 OPT oligopeptide transporter protein TruB_C_2 PF16198.5 EXF85055.1 - 0.099 12.8 0.5 0.33 11.1 0.1 1.9 1 1 1 2 2 2 0 tRNA pseudouridylate synthase B C-terminal domain zf-C4H2 PF10146.9 EXF85055.1 - 0.14 12.5 0.1 0.19 12.0 0.1 1.3 1 1 0 1 1 1 0 Zinc finger-containing protein RabGAP-TBC PF00566.18 EXF85056.1 - 3.9e-30 105.1 0.0 6.3e-30 104.4 0.0 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain SBE2 PF17076.5 EXF85056.1 - 2.3e-08 32.8 0.7 4e-08 32.0 0.7 1.3 1 0 0 1 1 1 1 SBE2, cell-wall formation eIF2A PF08662.11 EXF85057.1 - 2.6e-38 131.9 2.2 9.3e-35 120.3 0.2 3.6 2 2 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A RRM_1 PF00076.22 EXF85057.1 - 0.00032 20.5 0.0 0.00072 19.3 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) WD40 PF00400.32 EXF85057.1 - 0.0076 17.1 1.4 7 7.7 0.0 4.2 4 0 0 4 4 4 1 WD domain, G-beta repeat BofC_C PF08955.10 EXF85057.1 - 0.14 12.2 0.1 31 4.7 0.0 3.4 3 0 0 3 3 3 0 BofC C-terminal domain NIPSNAP PF07978.13 EXF85057.1 - 0.28 11.5 3.1 12 6.2 0.0 3.4 3 0 0 3 3 3 0 NIPSNAP Cpn60_TCP1 PF00118.24 EXF85058.1 - 3.8e-145 484.3 11.2 4.3e-145 484.1 11.2 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family CRM1_repeat PF18777.1 EXF85058.1 - 0.1 12.2 0.0 0.21 11.2 0.0 1.5 1 0 0 1 1 1 0 Chromosome region maintenance or exportin repeat DUF5442 PF17514.2 EXF85058.1 - 0.14 12.3 0.2 0.33 11.2 0.2 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5442) Glyco_transf_90 PF05686.12 EXF85059.1 - 2.3e-18 66.3 1.9 2.2e-13 49.9 0.9 3.1 2 1 0 2 2 2 2 Glycosyl transferase family 90 NACHT PF05729.12 EXF85060.1 - 6e-08 32.8 0.0 1.5e-07 31.5 0.0 1.7 1 0 0 1 1 1 1 NACHT domain DUF676 PF05057.14 EXF85060.1 - 5.1e-05 22.9 0.0 0.00011 21.8 0.0 1.5 1 0 0 1 1 1 1 Putative serine esterase (DUF676) AAA_16 PF13191.6 EXF85060.1 - 0.0002 21.8 0.0 0.00077 19.9 0.0 2.0 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EXF85060.1 - 0.00031 21.0 0.1 0.0042 17.4 0.0 2.6 2 0 0 2 2 2 1 AAA domain PGAP1 PF07819.13 EXF85060.1 - 0.00051 19.8 0.7 0.0031 17.3 0.0 2.4 3 0 0 3 3 3 1 PGAP1-like protein ATPase_2 PF01637.18 EXF85060.1 - 0.032 14.1 0.0 0.092 12.6 0.0 1.7 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea Hydrolase_4 PF12146.8 EXF85060.1 - 0.036 13.3 0.0 0.072 12.3 0.0 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Palm_thioest PF02089.15 EXF85060.1 - 0.043 13.7 0.0 0.079 12.8 0.0 1.4 1 0 0 1 1 1 0 Palmitoyl protein thioesterase KAP_NTPase PF07693.14 EXF85060.1 - 0.044 13.0 0.9 0.13 11.5 0.7 1.7 1 1 1 2 2 2 0 KAP family P-loop domain GHL15 PF14885.6 EXF85060.1 - 0.078 12.9 0.0 0.14 12.1 0.0 1.4 1 0 0 1 1 1 0 Hypothetical glycosyl hydrolase family 15 Cutinase PF01083.22 EXF85060.1 - 0.097 12.6 0.0 0.22 11.5 0.0 1.5 1 0 0 1 1 1 0 Cutinase FA_desaturase PF00487.24 EXF85063.1 - 2.3e-24 86.6 18.1 4.7e-24 85.6 18.1 1.4 1 1 0 1 1 1 1 Fatty acid desaturase DUF3474 PF11960.8 EXF85063.1 - 6.9e-08 32.8 0.0 1.3e-06 28.7 0.0 2.3 2 1 0 2 2 2 1 Domain of unknown function (DUF3474) BES1_N PF05687.13 EXF85063.1 - 1.3 9.4 3.8 2.4 8.5 3.8 1.4 1 0 0 1 1 1 0 BES1/BZR1 plant transcription factor, N-terminal Peptidase_M35 PF02102.15 EXF85065.1 - 3.2e-70 236.8 13.8 3.8e-70 236.6 13.8 1.0 1 0 0 1 1 1 1 Deuterolysin metalloprotease (M35) family Aspzincin_M35 PF14521.6 EXF85065.1 - 9.8e-39 133.2 4.1 2e-38 132.2 4.1 1.5 1 0 0 1 1 1 1 Lysine-specific metallo-endopeptidase Calycin_like PF13944.6 EXF85065.1 - 0.073 13.4 5.1 0.25 11.7 2.2 2.6 1 1 1 2 2 2 0 Calycin-like beta-barrel domain Ribonuc_2-5A PF06479.12 EXF85067.1 - 3.4e-42 143.6 0.0 7.5e-42 142.5 0.0 1.6 1 0 0 1 1 1 1 Ribonuclease 2-5A Pkinase PF00069.25 EXF85067.1 - 2.8e-40 138.4 0.0 8.3e-39 133.5 0.0 2.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF85067.1 - 1.9e-20 73.2 0.0 5.3e-19 68.5 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EXF85067.1 - 0.00088 18.7 0.1 0.0023 17.3 0.1 1.7 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EXF85067.1 - 0.0034 16.2 0.3 0.008 15.0 0.0 1.7 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 EXF85067.1 - 0.023 14.6 6.5 0.15 12.0 0.1 3.2 2 1 0 3 3 3 0 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.9 EXF85067.1 - 0.18 11.3 0.0 0.32 10.5 0.0 1.3 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Ndc1_Nup PF09531.10 EXF85067.1 - 7.8 5.0 8.3 1.9 7.1 0.8 2.2 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup zf-C3HC4_3 PF13920.6 EXF85068.1 - 4.7e-06 26.4 8.8 4.7e-06 26.4 8.8 3.3 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EXF85068.1 - 0.00058 19.6 12.3 0.00058 19.6 12.3 2.6 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Nbl1_Borealin_N PF10444.9 EXF85068.1 - 0.26 10.9 0.4 1.5 8.5 0.1 2.1 2 0 0 2 2 2 0 Nbl1 / Borealin N terminal Pyr_redox_2 PF07992.14 EXF85069.1 - 1.1e-52 179.2 0.2 1.5e-52 178.7 0.2 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EXF85069.1 - 1.4e-12 47.9 0.0 6.5e-11 42.6 0.1 2.9 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EXF85069.1 - 0.0083 15.4 0.6 3.4 6.8 0.0 2.4 1 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase EcoR124_C PF12008.8 EXF85069.1 - 0.023 14.3 0.6 0.046 13.4 0.0 1.6 2 0 0 2 2 2 0 Type I restriction and modification enzyme - subunit R C terminal NAD_binding_7 PF13241.6 EXF85069.1 - 0.085 13.3 0.0 12 6.4 0.0 2.6 2 0 0 2 2 2 0 Putative NAD(P)-binding MFS_1 PF07690.16 EXF85070.1 - 1.7e-21 76.6 55.2 4.6e-16 58.7 33.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily A_deaminase PF00962.22 EXF85071.1 - 1.4e-34 119.9 0.0 1.7e-34 119.6 0.0 1.1 1 0 0 1 1 1 1 Adenosine/AMP deaminase TatD_DNase PF01026.21 EXF85071.1 - 0.013 14.9 0.0 0.014 14.8 0.0 1.2 1 0 0 1 1 1 0 TatD related DNase ADH_zinc_N PF00107.26 EXF85073.1 - 1e-10 41.7 0.1 3e-10 40.2 0.1 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 EXF85073.1 - 0.018 15.0 0.0 0.032 14.1 0.0 1.4 1 0 0 1 1 1 0 N-terminal domain of oxidoreductase ADH_N PF08240.12 EXF85073.1 - 0.027 14.4 0.0 0.14 12.1 0.0 2.0 1 1 0 1 1 1 0 Alcohol dehydrogenase GroES-like domain Peptidase_S15 PF02129.18 EXF85074.1 - 8.5e-41 140.3 0.0 2.7e-38 132.1 0.0 2.2 1 1 1 2 2 2 2 X-Pro dipeptidyl-peptidase (S15 family) PepX_C PF08530.10 EXF85074.1 - 5.3e-22 78.9 0.0 8e-21 75.0 0.0 2.6 2 1 0 2 2 2 1 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain Pro-kuma_activ PF09286.11 EXF85075.1 - 2.1e-28 99.4 0.1 4.6e-28 98.3 0.0 1.6 2 0 0 2 2 2 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 EXF85075.1 - 3e-05 23.5 0.2 5.1e-05 22.7 0.2 1.3 1 0 0 1 1 1 1 Subtilase family Asp PF00026.23 EXF85076.1 - 1.1e-24 87.5 0.0 2.2e-24 86.5 0.0 1.4 1 1 0 1 1 1 1 Eukaryotic aspartyl protease p450 PF00067.22 EXF85077.1 - 4.3e-46 157.6 0.0 5.4e-46 157.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Paf1 PF03985.13 EXF85078.1 - 1.1e-85 288.2 0.1 1.2e-85 288.0 0.1 1.0 1 0 0 1 1 1 1 Paf1 Rer1 PF03248.13 EXF85079.1 - 4.3e-76 254.4 9.3 5e-76 254.2 9.3 1.0 1 0 0 1 1 1 1 Rer1 family ECH_1 PF00378.20 EXF85080.1 - 9.3e-77 257.7 0.0 1.1e-76 257.5 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EXF85080.1 - 1.3e-37 130.0 0.1 1.3e-34 120.2 0.1 2.0 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase Thg1 PF04446.12 EXF85080.1 - 0.037 14.1 0.0 0.075 13.1 0.0 1.5 1 0 0 1 1 1 0 tRNAHis guanylyltransferase DUF3438 PF11920.8 EXF85080.1 - 0.12 11.6 0.0 0.18 11.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3438) zf-C3HC4 PF00097.25 EXF85081.1 - 5e-07 29.5 4.9 5e-07 29.5 4.9 5.1 5 2 0 5 5 5 1 Zinc finger, C3HC4 type (RING finger) SH3_9 PF14604.6 EXF85081.1 - 8.3e-07 28.8 0.1 1.6e-06 27.9 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain zf-RING_UBOX PF13445.6 EXF85081.1 - 3.9e-06 26.8 4.5 3.9e-06 26.8 4.5 4.0 5 0 0 5 5 5 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EXF85081.1 - 9.9e-06 25.3 3.2 9.9e-06 25.3 3.2 5.6 6 1 1 7 7 7 1 Zinc finger, C3HC4 type (RING finger) SH3_1 PF00018.28 EXF85081.1 - 1.6e-05 24.4 0.1 3.6e-05 23.3 0.1 1.6 1 0 0 1 1 1 1 SH3 domain zf-RING_6 PF14835.6 EXF85081.1 - 2.5e-05 24.0 0.6 2.5e-05 24.0 0.6 3.7 3 0 0 3 3 3 1 zf-RING of BARD1-type protein zf-RING_2 PF13639.6 EXF85081.1 - 5.1e-05 23.5 4.9 5.1e-05 23.5 4.9 5.1 4 2 0 4 4 4 1 Ring finger domain zf-RING_5 PF14634.6 EXF85081.1 - 0.00027 20.8 3.8 0.00027 20.8 3.8 5.3 6 1 1 7 7 7 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 EXF85081.1 - 0.013 15.7 7.3 0.013 15.7 7.3 4.4 5 0 0 5 5 5 0 zinc finger of C3HC4-type, RING SH3_2 PF07653.17 EXF85081.1 - 0.031 13.9 0.1 0.11 12.2 0.0 1.9 2 0 0 2 2 2 0 Variant SH3 domain PALP PF00291.25 EXF85082.1 - 4.6e-67 226.5 0.2 5.4e-67 226.3 0.2 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme FANCF PF11107.8 EXF85083.1 - 0.014 14.6 0.3 0.025 13.8 0.3 1.4 1 0 0 1 1 1 0 Fanconi anemia group F protein (FANCF) Med26 PF08711.11 EXF85083.1 - 0.077 13.0 0.1 0.2 11.7 0.1 1.7 1 0 0 1 1 1 0 TFIIS helical bundle-like domain Ribosomal_L19 PF01245.20 EXF85084.1 - 4e-11 42.8 0.0 6e-11 42.3 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L19 SM-ATX PF14438.6 EXF85084.1 - 0.23 11.6 0.0 0.41 10.8 0.0 1.4 1 0 0 1 1 1 0 Ataxin 2 SM domain FAP PF07174.11 EXF85084.1 - 0.61 9.5 8.4 0.82 9.1 8.4 1.1 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) TrkH PF02386.16 EXF85085.1 - 7.5e-144 479.9 5.0 2.6e-143 478.1 1.5 2.0 2 0 0 2 2 2 2 Cation transport protein ERCC3_RAD25_C PF16203.5 EXF85087.1 - 1.7e-122 407.4 0.2 3e-122 406.6 0.2 1.4 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Helicase_C_3 PF13625.6 EXF85087.1 - 1.3e-33 115.8 0.0 1e-32 112.9 0.0 2.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EXF85087.1 - 6.9e-16 58.7 0.0 1.5e-15 57.6 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EXF85087.1 - 4.5e-11 43.1 0.1 1.2e-10 41.7 0.1 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 EXF85087.1 - 4.1e-07 29.0 0.0 5.3e-07 28.7 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain SBP_bac_6 PF13343.6 EXF85087.1 - 0.15 11.5 0.0 0.37 10.2 0.0 1.6 1 0 0 1 1 1 0 Bacterial extracellular solute-binding protein zf-CHY PF05495.12 EXF85088.1 - 8.1e-13 48.7 17.7 1.6e-12 47.7 17.7 1.5 1 1 0 1 1 1 1 CHY zinc finger Zn-ribbon_8 PF09723.10 EXF85088.1 - 0.032 14.4 11.5 0.49 10.6 7.2 2.6 2 0 0 2 2 2 0 Zinc ribbon domain zinc_ribbon_9 PF14369.6 EXF85088.1 - 0.91 9.8 9.9 0.41 10.9 6.2 2.4 1 1 1 2 2 2 0 zinc-ribbon RNA_POL_M_15KD PF02150.16 EXF85088.1 - 2.1 8.3 13.0 9.3 6.2 0.0 3.3 3 0 0 3 3 3 0 RNA polymerases M/15 Kd subunit HypA PF01155.19 EXF85088.1 - 3.9 7.5 13.2 4.5 7.3 10.1 2.1 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Proteasome PF00227.26 EXF85089.1 - 3.6e-55 186.4 0.1 5.4e-55 185.8 0.1 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EXF85089.1 - 1.2e-11 44.0 0.4 3.7e-11 42.5 0.1 1.9 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature Zn_clus PF00172.18 EXF85090.1 - 1e-07 31.9 11.4 2.3e-07 30.8 11.4 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EXF85090.1 - 0.018 13.9 0.0 0.021 13.6 0.0 1.2 1 0 0 1 1 1 0 Fungal specific transcription factor domain PSI_integrin PF17205.3 EXF85090.1 - 0.027 14.2 1.6 0.027 14.2 1.6 2.2 2 0 0 2 2 2 0 Integrin plexin domain FAD-oxidase_C PF02913.19 EXF85091.1 - 3.1e-59 200.6 0.0 4.4e-59 200.1 0.0 1.2 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 EXF85091.1 - 7.8e-40 135.8 0.6 1.5e-39 134.9 0.6 1.4 1 0 0 1 1 1 1 FAD binding domain CH PF00307.31 EXF85092.1 - 1.5e-46 157.1 0.1 4.2e-22 78.4 0.0 2.8 3 0 0 3 3 3 2 Calponin homology (CH) domain EFhand_Ca_insen PF08726.10 EXF85092.1 - 2.3e-23 82.0 0.3 1e-22 80.0 0.0 2.3 2 0 0 2 2 2 1 Ca2+ insensitive EF hand CAMSAP_CH PF11971.8 EXF85092.1 - 3.8e-11 42.7 0.1 7.5e-06 25.7 0.0 2.7 2 0 0 2 2 2 2 CAMSAP CH domain EF-hand_6 PF13405.6 EXF85092.1 - 0.00051 19.8 0.9 0.0029 17.4 0.1 2.7 3 0 0 3 3 3 1 EF-hand domain EF-hand_7 PF13499.6 EXF85092.1 - 0.0056 17.1 5.1 0.02 15.3 3.0 2.8 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.6 EXF85092.1 - 0.029 14.2 0.9 0.36 10.7 0.1 2.8 1 1 2 3 3 3 0 EF-hand domain pair EF-hand_1 PF00036.32 EXF85092.1 - 0.067 12.8 0.2 0.72 9.5 0.0 2.5 2 0 0 2 2 2 0 EF hand PSII_Pbs27 PF13326.6 EXF85092.1 - 0.12 12.7 1.4 0.3 11.4 1.4 1.6 1 0 0 1 1 1 0 Photosystem II Pbs27 Spectrin PF00435.21 EXF85092.1 - 0.53 10.8 4.3 5.3 7.6 2.1 2.6 2 0 0 2 2 2 0 Spectrin repeat Cytochrom_B562 PF07361.11 EXF85092.1 - 2.7 8.7 5.2 1.3 9.7 0.3 2.8 3 0 0 3 3 3 0 Cytochrome b562 VPS9 PF02204.18 EXF85093.1 - 2.1e-25 88.9 0.0 4.3e-25 87.9 0.0 1.6 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain DUF5601 PF18151.1 EXF85093.1 - 0.029 14.7 1.0 0.06 13.7 0.1 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF5601) Sigma70_ner PF04546.13 EXF85093.1 - 0.44 10.4 4.0 0.24 11.3 1.0 1.9 1 1 1 2 2 2 0 Sigma-70, non-essential region Lipase_3 PF01764.25 EXF85094.1 - 6.4e-06 26.1 0.1 1.8e-05 24.6 0.0 1.7 2 0 0 2 2 2 1 Lipase (class 3) UPF0227 PF05728.12 EXF85094.1 - 0.0031 17.5 0.0 0.0051 16.8 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0227) Abhydrolase_1 PF00561.20 EXF85094.1 - 0.023 14.4 0.0 0.041 13.5 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EXF85094.1 - 0.049 12.9 0.0 0.086 12.1 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 YL1 PF05764.13 EXF85095.1 - 1.5e-71 241.4 30.3 1.5e-71 241.4 30.3 3.0 3 0 0 3 3 3 1 YL1 nuclear protein YL1_C PF08265.11 EXF85095.1 - 1.7e-13 50.0 0.5 3e-13 49.3 0.5 1.4 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain FA_hydroxylase PF04116.13 EXF85098.1 - 1.3e-22 80.5 10.5 1.3e-22 80.5 10.5 2.1 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily TCTP PF00838.17 EXF85099.1 - 3.4e-70 235.7 1.6 3.9e-70 235.5 1.6 1.0 1 0 0 1 1 1 1 Translationally controlled tumour protein Mis12 PF05859.12 EXF85101.1 - 1.3e-44 151.5 0.4 2.4e-44 150.7 0.4 1.4 1 0 0 1 1 1 1 Mis12 protein F-box-like PF12937.7 EXF85102.1 - 4e-07 29.8 1.1 5.6e-07 29.4 0.0 1.9 2 0 0 2 2 2 1 F-box-like Peptidase_M14 PF00246.24 EXF85103.1 - 9e-63 212.8 0.0 1.1e-62 212.5 0.0 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase PPR_2 PF13041.6 EXF85104.1 - 3.5e-25 87.9 0.2 8.4e-11 41.9 0.0 6.0 5 1 1 6 6 6 5 PPR repeat family PPR_3 PF13812.6 EXF85104.1 - 5.4e-21 74.4 0.0 5.6e-10 39.2 0.0 4.5 4 0 0 4 4 4 3 Pentatricopeptide repeat domain PPR PF01535.20 EXF85104.1 - 9.4e-10 38.1 3.4 0.025 14.8 0.1 6.8 8 0 0 8 8 8 2 PPR repeat PPR_long PF17177.4 EXF85104.1 - 4.1e-09 36.1 0.0 0.00033 20.1 0.0 3.5 2 1 1 3 3 3 3 Pentacotripeptide-repeat region of PRORP PPR_1 PF12854.7 EXF85104.1 - 1.5e-07 31.0 0.0 0.094 12.4 0.0 4.5 5 0 0 5 5 5 3 PPR repeat MRP-S27 PF10037.9 EXF85104.1 - 0.0052 15.7 0.0 0.55 9.0 0.0 2.6 3 0 0 3 3 3 1 Mitochondrial 28S ribosomal protein S27 Exog_C PF18026.1 EXF85104.1 - 0.0083 16.2 0.0 11 6.2 0.0 3.8 3 0 0 3 3 3 1 Endo/exonuclease (EXOG) C-terminal domain GST_N PF02798.20 EXF85105.1 - 3.8e-08 33.6 0.1 6.6e-08 32.8 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EXF85105.1 - 5.8e-08 33.0 0.0 1.4e-07 31.8 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EXF85105.1 - 2.9e-06 27.5 0.0 1.6e-05 25.1 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EXF85105.1 - 5.6e-06 26.3 0.0 9.2e-06 25.6 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EXF85105.1 - 4.3e-05 23.6 0.0 9.6e-05 22.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EXF85105.1 - 0.0046 17.1 0.0 0.0099 16.1 0.0 1.6 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_5 PF16865.5 EXF85105.1 - 0.092 13.3 0.0 0.21 12.2 0.0 1.6 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain NDUF_B4 PF07225.12 EXF85106.1 - 0.0034 17.3 0.0 0.0036 17.2 0.0 1.1 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4) Tom7 PF08038.12 EXF85106.1 - 0.094 12.4 0.5 0.76 9.5 0.7 2.0 2 0 0 2 2 2 0 TOM7 family SAP18 PF06487.12 EXF85107.1 - 3.3e-44 150.5 0.0 4.4e-44 150.1 0.0 1.1 1 0 0 1 1 1 1 Sin3 associated polypeptide p18 (SAP18) Prp18 PF02840.15 EXF85108.1 - 2.1e-52 177.0 1.7 2.3e-52 176.8 0.0 1.9 2 0 0 2 2 2 1 Prp18 domain PRP4 PF08799.11 EXF85108.1 - 3.4e-13 48.9 2.2 3.4e-13 48.9 2.2 2.9 3 0 0 3 3 3 1 pre-mRNA processing factor 4 (PRP4) like CDC27 PF09507.10 EXF85108.1 - 0.15 11.4 19.8 0.26 10.6 19.8 1.3 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 CDC45 PF02724.14 EXF85108.1 - 3.1 6.0 11.3 3.4 5.8 11.3 1.2 1 0 0 1 1 1 0 CDC45-like protein Spem1 PF15670.5 EXF85108.1 - 5.7 6.4 7.6 13 5.3 7.6 1.6 1 1 0 1 1 1 0 Spermatid maturation protein 1 MFS_1 PF07690.16 EXF85110.1 - 1.4e-35 122.9 25.5 1.4e-35 122.9 25.5 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily MWFE PF15879.5 EXF85110.1 - 0.095 12.9 0.4 0.095 12.9 0.4 3.2 3 0 0 3 3 3 0 NADH-ubiquinone oxidoreductase MWFE subunit FAD_binding_3 PF01494.19 EXF85112.1 - 1.2e-77 261.6 0.0 1.5e-77 261.2 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 EXF85112.1 - 5.5e-05 22.9 0.0 0.00092 18.9 0.0 2.3 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EXF85112.1 - 0.0002 21.5 0.0 0.00049 20.3 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EXF85112.1 - 0.00024 20.5 0.0 0.075 12.2 0.0 2.5 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EXF85112.1 - 0.0052 16.1 0.0 0.0095 15.2 0.0 1.3 1 0 0 1 1 1 1 Thi4 family HI0933_like PF03486.14 EXF85112.1 - 0.0094 14.7 0.0 0.015 14.0 0.0 1.3 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox PF00070.27 EXF85112.1 - 0.0095 16.5 0.0 1.3 9.6 0.0 2.9 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EXF85112.1 - 0.012 15.0 0.0 0.072 12.4 0.0 2.1 2 0 0 2 2 2 0 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EXF85112.1 - 0.076 12.1 0.0 0.15 11.1 0.0 1.5 1 0 0 1 1 1 0 FAD binding domain Pyr_redox_3 PF13738.6 EXF85112.1 - 0.1 11.9 0.0 0.23 10.7 0.0 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Fungal_trans PF04082.18 EXF85113.1 - 1.1e-11 44.3 3.0 3.6e-11 42.6 3.0 1.9 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF85113.1 - 1.4e-09 37.9 7.8 2.7e-09 37.0 7.8 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pectate_lyase PF03211.13 EXF85114.1 - 1.2e-81 273.1 1.4 1.5e-81 272.8 1.4 1.1 1 0 0 1 1 1 1 Pectate lyase p450 PF00067.22 EXF85115.1 - 3.2e-39 135.0 0.0 1.6e-37 129.4 0.0 2.7 2 1 1 3 3 3 3 Cytochrome P450 Sugar_tr PF00083.24 EXF85116.1 - 3.3e-54 184.4 4.2 4e-54 184.2 4.2 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF85116.1 - 3.3e-20 72.3 8.7 4e-20 72.1 8.7 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 EXF85116.1 - 3e-08 32.6 1.4 3.6e-08 32.3 1.4 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_2 PF13347.6 EXF85116.1 - 3.8e-06 25.7 8.5 0.0066 15.1 0.1 2.4 2 1 1 3 3 3 2 MFS/sugar transport protein PUCC PF03209.15 EXF85116.1 - 0.048 12.7 1.7 0.082 11.9 0.7 1.7 1 1 1 2 2 2 0 PUCC protein Cellulase PF00150.18 EXF85117.1 - 2.8e-30 105.7 2.7 2.8e-30 105.7 2.7 1.7 2 0 0 2 2 2 1 Cellulase (glycosyl hydrolase family 5) Zn_clus PF00172.18 EXF85118.1 - 1.8e-10 40.8 11.9 3.7e-10 39.8 11.9 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-C2H2_2 PF12756.7 EXF85120.1 - 3.3e-26 91.6 0.6 5.8e-26 90.8 0.6 1.4 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) DUF1996 PF09362.10 EXF85121.1 - 9.8e-46 156.6 1.0 1.2e-45 156.3 1.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1996) GLEYA PF10528.9 EXF85124.1 - 1.4e-09 38.3 0.0 2.4e-09 37.5 0.0 1.3 1 0 0 1 1 1 1 GLEYA domain GFA PF04828.14 EXF85125.1 - 8.1e-15 54.9 0.8 8.1e-15 54.9 0.8 1.5 2 0 0 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme Polysacc_deac_1 PF01522.21 EXF85126.1 - 7e-26 90.6 0.0 1e-25 90.1 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide deacetylase Glyco_hydro_57 PF03065.15 EXF85126.1 - 0.006 15.8 0.0 0.0079 15.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 57 Corona_NS8 PF12093.8 EXF85126.1 - 0.053 14.1 0.0 0.92 10.1 0.0 2.3 2 0 0 2 2 2 0 Coronavirus NS8 protein DUF1451 PF07295.11 EXF85126.1 - 0.1 12.7 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 Zinc-ribbon containing domain adh_short PF00106.25 EXF85128.1 - 2.9e-24 85.6 0.0 1.5e-19 70.3 0.0 2.1 1 1 1 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EXF85128.1 - 1.4e-12 47.6 0.0 5.8e-11 42.4 0.0 2.0 1 1 1 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF85128.1 - 1e-08 35.3 0.1 9.8e-08 32.1 0.0 2.0 2 0 0 2 2 2 1 KR domain Epimerase PF01370.21 EXF85128.1 - 0.0067 15.9 0.0 0.0089 15.5 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EXF85128.1 - 0.2 10.8 0.0 0.27 10.3 0.0 1.1 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 EXF85128.1 - 0.26 10.6 0.0 0.34 10.3 0.0 1.1 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase ORMDL PF04061.14 EXF85130.1 - 3.9e-58 195.1 2.6 5.2e-58 194.7 2.6 1.2 1 0 0 1 1 1 1 ORMDL family Glyco_hydro_18 PF00704.28 EXF85132.1 - 2.9e-62 211.2 3.6 3.5e-62 210.9 3.6 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 GHL10 PF02638.15 EXF85132.1 - 0.13 11.3 0.0 0.2 10.7 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase-like 10 CCSAP PF15748.5 EXF85133.1 - 0.078 13.1 7.8 0.095 12.9 7.8 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated PPP4R2 PF09184.11 EXF85133.1 - 0.45 10.1 7.4 0.45 10.1 7.4 1.1 1 0 0 1 1 1 0 PPP4R2 Mitofilin PF09731.9 EXF85133.1 - 0.91 8.3 15.8 1.3 7.7 15.8 1.2 1 0 0 1 1 1 0 Mitochondrial inner membrane protein NOA36 PF06524.12 EXF85133.1 - 1.4 8.1 7.0 1.7 7.9 7.0 1.1 1 0 0 1 1 1 0 NOA36 protein DUF773 PF05600.12 EXF85134.1 - 0.13 11.0 2.8 0.22 10.2 2.8 1.3 1 0 0 1 1 1 0 CDK5 regulatory subunit-associated protein 3 CENP-B_dimeris PF09026.10 EXF85134.1 - 0.52 10.7 0.0 0.52 10.7 0.0 3.2 3 0 0 3 3 3 0 Centromere protein B dimerisation domain M20_dimer PF07687.14 EXF85136.1 - 3.1e-25 88.2 0.0 9.1e-25 86.7 0.0 1.7 2 0 0 2 2 2 1 Peptidase dimerisation domain Peptidase_M20 PF01546.28 EXF85136.1 - 4.9e-18 65.6 1.4 1.1e-16 61.2 1.4 2.1 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M28 PF04389.17 EXF85136.1 - 0.0011 18.7 0.0 0.0026 17.5 0.0 1.6 2 0 0 2 2 2 1 Peptidase family M28 ADH_zinc_N PF00107.26 EXF85137.1 - 1.2e-16 60.9 0.8 4.5e-16 59.0 0.4 2.0 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EXF85137.1 - 8.9e-09 36.5 0.0 2.7e-08 35.0 0.0 1.8 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EXF85137.1 - 0.0083 16.0 0.0 0.027 14.4 0.0 1.8 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain zf-MYND PF01753.18 EXF85138.1 - 0.065 13.3 12.9 0.12 12.5 12.9 1.4 1 0 0 1 1 1 0 MYND finger zf-HIT PF04438.16 EXF85138.1 - 0.068 13.1 9.8 0.13 12.1 9.8 1.5 1 0 0 1 1 1 0 HIT zinc finger D123 PF07065.14 EXF85140.1 - 1.8e-13 50.3 0.0 2.6e-13 49.8 0.0 1.1 1 0 0 1 1 1 1 D123 R2K_3 PF14243.6 EXF85140.1 - 0.00074 19.6 0.0 0.0014 18.7 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain, R2K clade family 3 R2K_2 PF18299.1 EXF85140.1 - 0.14 12.0 0.0 0.3 10.9 0.0 1.6 1 0 0 1 1 1 0 ATP-grasp domain, R2K clade family 2 Peptidase_S8 PF00082.22 EXF85144.1 - 8.2e-47 159.9 0.3 1.2e-46 159.3 0.3 1.2 1 0 0 1 1 1 1 Subtilase family fn3_5 PF06280.12 EXF85144.1 - 3e-05 24.7 0.0 6.8e-05 23.5 0.0 1.7 1 0 0 1 1 1 1 Fn3-like domain Inhibitor_I9 PF05922.16 EXF85144.1 - 0.0089 16.7 0.0 0.017 15.8 0.0 1.4 1 0 0 1 1 1 1 Peptidase inhibitor I9 PA PF02225.22 EXF85144.1 - 0.039 14.0 0.0 0.11 12.6 0.0 1.7 1 0 0 1 1 1 0 PA domain Sugar_tr PF00083.24 EXF85145.1 - 1.8e-81 274.3 22.2 2.2e-81 274.0 22.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF85145.1 - 2.2e-31 109.1 49.3 7.2e-19 67.9 16.9 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 EXF85145.1 - 0.001 17.5 2.5 0.001 17.5 2.5 2.4 1 1 1 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family DUF4950 PF16308.5 EXF85146.1 - 0.073 13.1 0.6 0.1 12.6 0.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4950) PSII PF00421.19 EXF85147.1 - 0.012 14.3 0.0 0.012 14.3 0.0 1.0 1 0 0 1 1 1 0 Photosystem II protein Peptidase_A4 PF01828.17 EXF85148.1 - 1.8e-69 233.4 16.9 2.1e-69 233.2 16.9 1.1 1 0 0 1 1 1 1 Peptidase A4 family CARDB PF07705.11 EXF85148.1 - 0.11 12.7 2.3 0.26 11.6 0.3 2.5 2 1 0 2 2 2 0 CARDB PASTA PF03793.19 EXF85148.1 - 0.4 10.6 3.5 1.5 8.7 0.5 3.2 4 0 0 4 4 4 0 PASTA domain Peptidase_S10 PF00450.22 EXF85149.1 - 7.6e-79 266.1 1.6 1e-78 265.6 1.6 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase Abhydrolase_6 PF12697.7 EXF85149.1 - 0.0055 17.3 0.2 0.0096 16.6 0.0 1.8 2 1 0 2 2 2 1 Alpha/beta hydrolase family HET PF06985.11 EXF85150.1 - 9.7e-10 39.0 0.0 2.8e-09 37.5 0.0 1.8 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Peptidase_C14 PF00656.22 EXF85151.1 - 5.6e-24 85.4 0.0 9.4e-24 84.7 0.0 1.3 1 0 0 1 1 1 1 Caspase domain Raptor_N PF14538.6 EXF85151.1 - 0.072 13.0 0.0 0.31 11.0 0.0 2.0 1 1 0 1 1 1 0 Raptor N-terminal CASPase like domain Pyridoxal_deC PF00282.19 EXF85152.1 - 2.3e-15 56.2 0.0 2.4e-14 52.9 0.0 2.1 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Beta_elim_lyase PF01212.21 EXF85152.1 - 0.03 13.6 0.0 0.051 12.8 0.0 1.3 1 0 0 1 1 1 0 Beta-eliminating lyase CHAT PF12770.7 EXF85154.1 - 1e-35 123.6 0.0 1.8e-35 122.8 0.0 1.4 1 0 0 1 1 1 1 CHAT domain TPR_2 PF07719.17 EXF85154.1 - 0.051 13.7 1.9 33 4.9 0.2 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat Peptidase_C50 PF03568.17 EXF85154.1 - 0.052 12.7 0.0 0.13 11.3 0.0 1.6 1 1 0 1 1 1 0 Peptidase family C50 Peptidase_C14 PF00656.22 EXF85154.1 - 0.14 12.1 0.0 0.28 11.1 0.0 1.4 1 0 0 1 1 1 0 Caspase domain TPR_12 PF13424.6 EXF85154.1 - 0.14 12.4 5.8 13 6.1 0.3 5.3 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_1 PF00515.28 EXF85154.1 - 1.3 9.0 3.4 11 6.0 0.1 3.8 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_10 PF13374.6 EXF85154.1 - 1.8 8.5 21.6 0.06 13.2 0.7 6.3 7 0 0 7 7 7 0 Tetratricopeptide repeat DUF5633 PF18656.1 EXF85154.1 - 3.3 7.7 4.5 1.2 9.0 0.2 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5633) ECH_1 PF00378.20 EXF85155.1 - 2.5e-27 95.8 0.0 3.2e-27 95.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EXF85155.1 - 3.7e-09 36.6 0.0 5.3e-09 36.0 0.0 1.3 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase adh_short PF00106.25 EXF85156.1 - 5.1e-22 78.3 0.0 4.1e-20 72.1 0.0 2.1 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF85156.1 - 6.5e-10 39.0 0.0 1.6e-08 34.4 0.0 2.1 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF85156.1 - 6.6e-07 29.4 0.3 1.8e-06 28.0 0.0 1.8 2 0 0 2 2 2 1 KR domain Polysacc_synt_2 PF02719.15 EXF85156.1 - 0.0076 15.4 0.0 0.011 14.9 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.21 EXF85156.1 - 0.1 12.1 0.0 0.23 10.9 0.0 1.5 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family LOR PF04525.12 EXF85157.1 - 2.6e-20 72.8 0.0 3.2e-20 72.5 0.0 1.0 1 0 0 1 1 1 1 LURP-one-related Gryzun PF07919.12 EXF85157.1 - 0.18 10.5 0.0 0.25 10.0 0.0 1.1 1 0 0 1 1 1 0 Gryzun, putative trafficking through Golgi Bac_rhamnosid6H PF17389.2 EXF85158.1 - 2.4e-10 40.2 0.3 1.1e-09 38.0 0.3 1.9 2 1 0 2 2 2 1 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain Bac_rhamnosid_C PF17390.2 EXF85158.1 - 1.1e-05 25.2 0.0 3.2e-05 23.6 0.0 1.7 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase C-terminal domain Trehalase PF01204.18 EXF85158.1 - 0.0086 14.9 0.0 0.013 14.4 0.0 1.1 1 0 0 1 1 1 1 Trehalase YCII PF03795.14 EXF85159.1 - 3.6e-11 43.3 0.0 4.6e-11 43.0 0.0 1.1 1 0 0 1 1 1 1 YCII-related domain Fungal_trans PF04082.18 EXF85160.1 - 1.5e-14 53.7 0.0 3.2e-14 52.6 0.0 1.4 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF85160.1 - 0.009 16.1 5.0 0.016 15.3 5.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SelP_N PF04592.14 EXF85160.1 - 0.85 9.0 5.9 1.7 8.0 5.9 1.4 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Flavin_Reduct PF01613.18 EXF85161.1 - 1.2e-18 67.6 0.0 1.8e-18 67.1 0.0 1.2 1 0 0 1 1 1 1 Flavin reductase like domain Putative_PNPOx PF01243.20 EXF85161.1 - 0.036 14.3 0.0 0.069 13.3 0.0 1.4 1 0 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase Pro_dh PF01619.18 EXF85163.1 - 2.4e-64 217.7 0.0 3e-64 217.4 0.0 1.1 1 0 0 1 1 1 1 Proline dehydrogenase TraB PF01963.17 EXF85163.1 - 0.051 13.5 0.6 0.25 11.2 0.1 2.0 1 1 1 2 2 2 0 TraB family Tenui_NCP PF04876.12 EXF85163.1 - 0.084 12.5 0.0 0.25 10.9 0.0 1.7 1 1 1 2 2 2 0 Tenuivirus major non-capsid protein MFS_1 PF07690.16 EXF85165.1 - 1.5e-27 96.5 66.1 1.7e-23 83.1 35.9 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Arrestin_C PF02752.22 EXF85166.1 - 1.1e-09 38.9 0.0 9.2e-08 32.6 0.0 2.2 2 0 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 EXF85166.1 - 0.0002 21.5 0.1 0.00039 20.5 0.1 1.5 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain LDB19 PF13002.7 EXF85166.1 - 0.0064 16.2 0.0 0.012 15.3 0.0 1.4 1 0 0 1 1 1 1 Arrestin_N terminal like Exo_endo_phos PF03372.23 EXF85168.1 - 3.6e-06 26.7 0.6 1.4e-05 24.7 0.6 2.3 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 EXF85168.1 - 0.02 14.7 0.0 0.049 13.5 0.0 1.7 1 1 0 1 1 1 0 Endonuclease-reverse transcriptase LIP PF03583.14 EXF85169.1 - 7.8e-07 28.7 0.6 2.3e-05 23.9 0.6 2.4 1 1 0 1 1 1 1 Secretory lipase Hydrolase_4 PF12146.8 EXF85169.1 - 2.4e-06 27.0 0.3 5.4e-05 22.6 0.3 2.1 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EXF85169.1 - 6.3e-06 26.9 2.0 1e-05 26.2 2.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 EXF85169.1 - 0.0011 18.5 1.3 0.016 14.7 0.0 2.4 2 1 1 3 3 3 1 Prolyl oligopeptidase family DLH PF01738.18 EXF85169.1 - 0.004 16.8 0.0 0.049 13.2 0.0 2.1 2 0 0 2 2 2 1 Dienelactone hydrolase family Epimerase PF01370.21 EXF85170.1 - 8.9e-08 31.9 0.0 1.3e-07 31.3 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family KR PF08659.10 EXF85170.1 - 0.12 12.3 0.0 0.19 11.6 0.0 1.2 1 0 0 1 1 1 0 KR domain HhH-GPD PF00730.25 EXF85171.1 - 0.00014 22.3 0.0 0.00025 21.5 0.0 1.5 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein ABC_tran PF00005.27 EXF85172.1 - 2.5e-31 109.0 0.0 6.1e-31 107.8 0.0 1.7 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 EXF85172.1 - 5.9e-25 88.4 3.3 8.9e-25 87.9 3.3 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 EXF85172.1 - 1.7e-06 27.6 0.0 2.7e-05 23.7 0.0 2.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 EXF85172.1 - 0.0022 17.9 0.0 0.0057 16.6 0.0 1.7 1 0 0 1 1 1 1 RsgA GTPase AAA_22 PF13401.6 EXF85172.1 - 0.0026 18.0 0.1 0.02 15.2 0.1 2.3 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EXF85172.1 - 0.016 15.6 0.2 0.056 13.8 0.2 1.9 1 1 0 1 1 1 0 AAA ATPase domain Zeta_toxin PF06414.12 EXF85172.1 - 0.017 14.4 0.1 0.037 13.3 0.1 1.5 1 0 0 1 1 1 0 Zeta toxin MMR_HSR1 PF01926.23 EXF85172.1 - 0.018 15.1 0.1 0.2 11.8 0.0 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_10 PF12846.7 EXF85172.1 - 0.023 13.6 0.0 0.063 12.2 0.0 1.7 2 0 0 2 2 2 0 AAA-like domain DUF87 PF01935.17 EXF85172.1 - 0.036 14.2 0.1 0.095 12.8 0.1 1.6 1 0 0 1 1 1 0 Helicase HerA, central domain AAA_15 PF13175.6 EXF85172.1 - 0.04 13.6 0.0 0.071 12.8 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain DUF815 PF05673.13 EXF85172.1 - 0.051 12.7 0.0 0.11 11.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) PBP1_TM PF14812.6 EXF85172.1 - 0.057 13.8 2.0 0.059 13.7 0.5 1.8 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal AAA_29 PF13555.6 EXF85172.1 - 0.099 12.4 0.1 0.37 10.6 0.1 2.0 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_7 PF12775.7 EXF85172.1 - 0.11 12.0 0.2 0.27 10.7 0.0 1.7 2 0 0 2 2 2 0 P-loop containing dynein motor region TsaE PF02367.17 EXF85172.1 - 0.12 12.3 0.0 0.27 11.3 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE FAD_binding_3 PF01494.19 EXF85173.1 - 9.4e-13 48.1 1.4 1.6e-08 34.2 0.0 3.0 3 0 0 3 3 3 2 FAD binding domain Pyr_redox_2 PF07992.14 EXF85173.1 - 0.012 14.8 2.8 1.4 8.1 0.1 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EXF85173.1 - 0.018 13.9 0.4 0.56 9.0 0.0 2.7 3 0 0 3 3 3 0 Tryptophan halogenase PhyH PF05721.13 EXF85174.1 - 3.1e-09 37.4 0.0 5.6e-09 36.6 0.0 1.4 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) DUF1479 PF07350.12 EXF85174.1 - 0.00012 21.0 0.0 0.06 12.1 0.1 2.9 3 0 0 3 3 3 2 Protein of unknown function (DUF1479) 2OG-FeII_Oxy_5 PF13759.6 EXF85174.1 - 0.027 14.9 0.0 0.056 13.9 0.0 1.5 1 0 0 1 1 1 0 Putative 2OG-Fe(II) oxygenase MFS_1 PF07690.16 EXF85175.1 - 7.3e-14 51.5 22.0 7.3e-14 51.5 22.0 2.2 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF85175.1 - 5.3e-11 42.0 11.6 2.5e-09 36.5 2.7 3.3 2 2 1 3 3 3 2 Sugar (and other) transporter Peptidase_S15 PF02129.18 EXF85176.1 - 2.6e-37 128.9 0.1 4.6e-36 124.8 0.0 2.0 1 1 1 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) PepX_C PF08530.10 EXF85176.1 - 5.5e-35 121.3 0.0 7.7e-35 120.9 0.0 1.2 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain PhyH PF05721.13 EXF85177.1 - 0.00016 22.0 0.0 0.00052 20.3 0.0 1.9 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) DUF1479 PF07350.12 EXF85177.1 - 0.012 14.4 0.1 0.61 8.8 0.1 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF1479) Methyltransf_18 PF12847.7 EXF85177.1 - 0.12 12.3 0.0 0.19 11.6 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Fungal_trans PF04082.18 EXF85178.1 - 6.5e-23 81.1 0.0 1.1e-22 80.3 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF85178.1 - 4.9e-10 39.4 12.0 8.7e-10 38.6 12.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain EndIII_4Fe-2S PF10576.9 EXF85178.1 - 0.92 9.9 3.4 3.1 8.2 3.4 2.0 1 0 0 1 1 1 0 Iron-sulfur binding domain of endonuclease III Pullulanase_N2 PF17967.1 EXF85179.1 - 0.11 13.3 0.0 0.12 13.3 0.0 1.0 1 0 0 1 1 1 0 Pullulanase N2 domain PAS_3 PF08447.12 EXF85180.1 - 0.12 12.6 0.0 0.3 11.4 0.0 1.6 1 1 0 1 1 1 0 PAS fold H_lectin PF09458.10 EXF85181.1 - 3.6e-55 184.0 0.0 6.4e-19 67.9 0.0 3.4 3 0 0 3 3 3 3 H-type lectin domain Astacin PF01400.24 EXF85181.1 - 4e-06 26.6 0.2 1.5e-05 24.7 0.2 2.0 1 1 0 1 1 1 1 Astacin (Peptidase family M12A) Peptidase_M10 PF00413.24 EXF85181.1 - 9e-05 22.4 3.5 0.00054 19.8 3.5 2.1 1 1 0 1 1 1 1 Matrixin Reprolysin_5 PF13688.6 EXF85181.1 - 0.00016 21.9 0.1 0.00067 19.9 0.0 2.0 2 0 0 2 2 2 1 Metallo-peptidase family M12 DUF3810 PF12725.7 EXF85181.1 - 0.013 14.9 0.9 0.02 14.2 0.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) Reprolysin_3 PF13582.6 EXF85181.1 - 0.02 15.4 0.1 0.05 14.1 0.1 1.7 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 EXF85181.1 - 0.03 14.2 0.0 0.058 13.3 0.0 1.5 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Zincin_1 PF06262.11 EXF85181.1 - 0.035 14.2 0.3 0.081 13.0 0.3 1.6 1 0 0 1 1 1 0 Zincin-like metallopeptidase Peptidase_M57 PF12388.8 EXF85181.1 - 0.22 11.1 0.0 0.36 10.4 0.0 1.3 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase COesterase PF00135.28 EXF85182.1 - 1e-53 183.0 0.0 1.2e-53 182.7 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Sulfotransfer_3 PF13469.6 EXF85182.1 - 0.016 15.6 0.0 0.026 14.9 0.0 1.3 1 0 0 1 1 1 0 Sulfotransferase family Abhydrolase_3 PF07859.13 EXF85182.1 - 0.16 11.8 0.3 0.92 9.3 0.3 2.1 1 1 0 1 1 1 0 alpha/beta hydrolase fold HET PF06985.11 EXF85184.1 - 2.2e-21 76.8 0.0 4.4e-21 75.8 0.0 1.5 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) HEV_ORF1 PF02444.16 EXF85185.1 - 0.033 14.8 0.1 0.072 13.7 0.0 1.6 1 1 0 1 1 1 0 Hepatitis E virus ORF-2 (Putative capsid protein) Aldo_ket_red PF00248.21 EXF85186.1 - 1.1e-61 208.6 0.0 1.3e-61 208.4 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family ADH_N PF08240.12 EXF85187.1 - 1.1e-14 54.2 0.0 3.1e-14 52.8 0.0 1.8 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EXF85187.1 - 1.3e-06 28.4 0.3 4.6e-06 26.6 0.3 1.9 1 1 0 1 1 1 1 Zinc-binding dehydrogenase HI0933_like PF03486.14 EXF85187.1 - 0.00018 20.4 0.1 0.00024 20.0 0.1 1.1 1 0 0 1 1 1 1 HI0933-like protein AlaDh_PNT_C PF01262.21 EXF85187.1 - 0.0016 17.8 0.1 0.003 16.9 0.1 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Glu_dehyd_C PF16912.5 EXF85187.1 - 0.0082 15.6 0.0 0.015 14.8 0.0 1.4 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus FAD_binding_2 PF00890.24 EXF85187.1 - 0.011 14.9 1.2 0.016 14.3 1.2 1.2 1 0 0 1 1 1 0 FAD binding domain FAD_binding_3 PF01494.19 EXF85187.1 - 0.18 11.0 0.2 0.28 10.4 0.2 1.2 1 0 0 1 1 1 0 FAD binding domain DUF4419 PF14388.6 EXF85188.1 - 4.4e-05 23.1 0.0 4.5e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4419) Glyco_hydro_43 PF04616.14 EXF85189.1 - 1.9e-50 171.8 0.4 2.4e-50 171.5 0.4 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 CBM_6 PF03422.15 EXF85189.1 - 4.5e-33 114.2 0.3 9e-33 113.2 0.3 1.5 1 0 0 1 1 1 1 Carbohydrate binding module (family 6) DUF5010_C PF18099.1 EXF85189.1 - 2.2e-08 34.2 0.1 4e-08 33.4 0.1 1.4 1 0 0 1 1 1 1 DUF5010 C-terminal domain Glyco_hydro_32N PF00251.20 EXF85189.1 - 0.00085 19.0 0.2 0.0015 18.2 0.2 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 N-terminal domain GCM PF03615.15 EXF85190.1 - 0.058 13.3 0.0 0.1 12.5 0.0 1.4 1 1 0 1 1 1 0 GCM motif protein HET PF06985.11 EXF85191.1 - 2.1e-22 80.0 0.0 3.9e-22 79.2 0.0 1.5 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) NfrA_C PF13283.6 EXF85191.1 - 0.13 11.7 0.0 4.9 6.6 0.0 2.4 2 0 0 2 2 2 0 Bacteriophage N adsorption protein A C-term Glycos_transf_2 PF00535.26 EXF85193.1 - 8.3e-20 71.3 0.0 1.3e-19 70.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 EXF85193.1 - 1.2e-17 64.0 0.0 1.8e-17 63.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glyco_trans_2_3 PF13632.6 EXF85193.1 - 9.8e-17 61.5 0.3 9.8e-17 61.5 0.3 2.5 2 1 1 3 3 3 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 EXF85193.1 - 4.8e-12 46.3 0.0 6.8e-12 45.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Cellulose_synt PF03552.14 EXF85193.1 - 2e-05 23.4 0.7 0.0052 15.4 0.2 2.3 2 0 0 2 2 2 2 Cellulose synthase Glyco_hydro_12 PF01670.16 EXF85194.1 - 1.8e-13 51.0 9.0 2.9e-11 43.8 2.4 2.1 1 1 1 2 2 2 2 Glycosyl hydrolase family 12 UDPG_MGDP_dh_N PF03721.14 EXF85196.1 - 3.1e-33 114.9 0.0 4.8e-19 68.7 0.1 2.1 1 1 1 2 2 2 2 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_binding_2 PF03446.15 EXF85196.1 - 0.0083 16.3 0.0 0.18 12.0 0.0 2.2 1 1 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Sacchrp_dh_NADP PF03435.18 EXF85196.1 - 0.022 15.0 0.0 0.045 14.0 0.0 1.7 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain 3HCDH_N PF02737.18 EXF85196.1 - 0.11 12.3 0.0 0.32 10.9 0.0 1.8 1 1 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GFO_IDH_MocA PF01408.22 EXF85196.1 - 0.12 13.2 0.1 1.6 9.5 0.1 2.2 1 1 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold Glyco_hydro_43 PF04616.14 EXF85197.1 - 4e-17 62.5 0.6 5.6e-17 62.0 0.6 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 GH43_C2 PF17851.1 EXF85197.1 - 8.1e-13 48.5 0.0 2.6e-12 46.9 0.0 1.7 1 1 0 1 1 1 1 Beta xylosidase C-terminal Concanavalin A-like domain S-layer PF07752.11 EXF85197.1 - 0.14 11.2 0.2 0.29 10.2 0.0 1.5 2 0 0 2 2 2 0 S-layer protein RTA1 PF04479.13 EXF85198.1 - 2.3e-33 115.5 4.7 3.5e-33 115.0 4.7 1.2 1 0 0 1 1 1 1 RTA1 like protein Peptidase_M10 PF00413.24 EXF85198.1 - 1.9e-07 31.0 0.1 8.8e-07 28.9 0.0 2.1 3 0 0 3 3 3 1 Matrixin Reprolysin_4 PF13583.6 EXF85198.1 - 1.9e-05 24.4 0.0 3.2e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 EXF85198.1 - 7.9e-05 22.9 0.0 0.00018 21.8 0.0 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.6 EXF85198.1 - 0.0008 19.9 0.0 0.0022 18.5 0.0 1.8 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like DUF4953 PF16313.5 EXF85198.1 - 0.00086 18.6 0.0 0.0021 17.4 0.0 1.6 1 0 0 1 1 1 1 Met-zincin Reprolysin_2 PF13574.6 EXF85198.1 - 0.003 17.5 0.0 0.0052 16.7 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M43 PF05572.13 EXF85198.1 - 0.019 14.9 0.0 0.035 14.0 0.0 1.3 1 0 0 1 1 1 0 Pregnancy-associated plasma protein-A Peptidase_M48 PF01435.18 EXF85198.1 - 0.028 14.2 0.2 0.1 12.3 0.0 1.8 2 0 0 2 2 2 0 Peptidase family M48 p12I PF12233.8 EXF85198.1 - 0.52 10.8 2.9 2.3 8.8 0.1 2.3 2 0 0 2 2 2 0 Human adult T cell leukemia/lymphoma virus protein p450 PF00067.22 EXF85199.1 - 7.4e-35 120.6 0.0 9e-35 120.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 EXF85200.1 - 2.1e-60 204.8 0.0 2.4e-60 204.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 GerA PF03323.13 EXF85200.1 - 0.22 9.9 0.1 0.33 9.4 0.1 1.2 1 0 0 1 1 1 0 Bacillus/Clostridium GerA spore germination protein CcmH PF03918.14 EXF85201.1 - 0.068 12.5 0.0 0.1 11.9 0.0 1.4 1 0 0 1 1 1 0 Cytochrome C biogenesis protein MFS_1 PF07690.16 EXF85202.1 - 5.8e-40 137.3 82.5 8.3e-38 130.2 50.6 2.7 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EXF85202.1 - 5.1e-14 51.6 15.3 7.1e-14 51.1 15.3 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) FSH1 PF03959.13 EXF85203.1 - 2.9e-28 99.0 0.0 4.4e-27 95.1 0.0 2.2 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_6 PF12697.7 EXF85203.1 - 2.7e-07 31.4 2.7 3.6e-07 31.0 2.7 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.16 EXF85203.1 - 0.016 15.0 0.9 0.16 11.8 0.9 2.1 1 1 0 1 1 1 0 Phospholipase/Carboxylesterase MFS_1 PF07690.16 EXF85204.1 - 3.5e-21 75.5 30.7 3.5e-21 75.5 30.7 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF85204.1 - 1.2e-06 27.6 4.2 1.2e-06 27.6 4.2 2.0 2 0 0 2 2 2 1 Sugar (and other) transporter Tail_VII PF17091.5 EXF85204.1 - 0.066 13.1 0.7 0.2 11.5 0.7 1.8 1 0 0 1 1 1 0 Inovirus G7P protein Dynactin_p62 PF05502.13 EXF85204.1 - 0.22 10.3 0.3 0.31 9.8 0.3 1.1 1 0 0 1 1 1 0 Dynactin p62 family LapA_dom PF06305.11 EXF85204.1 - 2.3 8.1 6.2 2.5 8.0 0.0 3.5 3 0 0 3 3 3 0 Lipopolysaccharide assembly protein A domain GFA PF04828.14 EXF85205.1 - 5.7e-08 33.0 0.3 1e-07 32.2 0.3 1.4 1 1 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme p450 PF00067.22 EXF85206.1 - 9.8e-56 189.4 0.1 1.2e-55 189.1 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 MBOAT_2 PF13813.6 EXF85207.1 - 2.2e-19 69.5 2.1 2.2e-19 69.5 2.1 2.1 2 0 0 2 2 2 1 Membrane bound O-acyl transferase family ketoacyl-synt PF00109.26 EXF85208.1 - 5.3e-70 235.9 0.0 1e-69 234.9 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.10 EXF85208.1 - 1.3e-61 207.7 0.1 3.3e-61 206.3 0.1 1.8 1 0 0 1 1 1 1 KR domain PS-DH PF14765.6 EXF85208.1 - 6.8e-54 183.1 0.0 1.2e-53 182.3 0.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 EXF85208.1 - 2.4e-47 162.0 0.3 4.1e-47 161.3 0.3 1.3 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EXF85208.1 - 3.1e-32 111.1 0.2 7.3e-31 106.6 0.0 2.8 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 EXF85208.1 - 1e-16 61.4 0.1 1.5e-15 57.6 0.1 2.6 1 1 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension ADH_zinc_N PF00107.26 EXF85208.1 - 2.9e-12 46.7 0.4 1.7e-11 44.2 0.3 2.4 2 0 0 2 2 2 1 Zinc-binding dehydrogenase adh_short PF00106.25 EXF85208.1 - 4e-08 33.0 2.3 5.7e-08 32.4 0.0 2.4 3 0 0 3 3 3 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF85208.1 - 4.2e-05 23.2 0.6 0.00018 21.2 0.0 2.3 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase ADH_zinc_N_2 PF13602.6 EXF85208.1 - 0.00015 22.8 0.4 0.01 16.9 0.1 3.8 3 0 0 3 3 3 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EXF85208.1 - 0.00024 20.9 0.3 0.00066 19.5 0.3 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain PP-binding PF00550.25 EXF85208.1 - 0.00096 19.5 0.0 0.0029 17.9 0.0 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site ACP_syn_III PF08545.10 EXF85208.1 - 0.0032 17.3 1.0 0.013 15.3 0.0 2.6 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Thiolase_N PF00108.23 EXF85208.1 - 0.0048 16.3 0.0 0.01 15.2 0.0 1.5 1 0 0 1 1 1 1 Thiolase, N-terminal domain Zn_clus PF00172.18 EXF85209.1 - 9.2e-09 35.3 8.9 9.2e-09 35.3 8.9 1.7 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ADH_zinc_N PF00107.26 EXF85210.1 - 2.9e-18 66.1 0.1 4.1e-18 65.6 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 EXF85210.1 - 9.6e-17 60.8 0.0 2.3e-16 59.6 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N_2 PF13602.6 EXF85210.1 - 1e-07 33.1 0.0 1.9e-07 32.2 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase FSH1 PF03959.13 EXF85211.1 - 1e-21 77.6 0.0 2.6e-21 76.3 0.0 1.6 1 1 0 1 1 1 1 Serine hydrolase (FSH1) AXE1 PF05448.12 EXF85212.1 - 3.1e-10 39.2 0.0 1.8e-06 26.9 0.0 2.1 2 0 0 2 2 2 2 Acetyl xylan esterase (AXE1) Hydrolase_4 PF12146.8 EXF85212.1 - 9e-08 31.7 0.0 2.1e-07 30.4 0.0 1.5 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EXF85212.1 - 1.8e-05 25.4 0.0 2.1e-05 25.3 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 EXF85212.1 - 0.00067 19.2 0.0 0.1 12.0 0.0 2.1 2 0 0 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 EXF85212.1 - 0.0018 18.0 0.0 0.022 14.4 0.0 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold BAAT_C PF08840.11 EXF85212.1 - 0.0062 16.5 0.0 0.0097 15.8 0.0 1.3 1 0 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal PS-DH PF14765.6 EXF85213.1 - 4.2e-53 180.5 0.0 7.6e-53 179.7 0.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase KR PF08659.10 EXF85213.1 - 7.5e-53 179.1 0.9 3e-52 177.2 0.9 2.1 1 0 0 1 1 1 1 KR domain Acyl_transf_1 PF00698.21 EXF85213.1 - 3.2e-44 151.7 0.0 5.1e-44 151.1 0.0 1.3 1 0 0 1 1 1 1 Acyl transferase domain ketoacyl-synt PF00109.26 EXF85213.1 - 4.5e-43 147.7 0.0 6.9e-32 111.0 0.0 2.7 1 1 1 2 2 2 2 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 EXF85213.1 - 4.6e-35 120.2 0.1 1.4e-34 118.6 0.1 1.9 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain ADH_zinc_N_2 PF13602.6 EXF85213.1 - 1.8e-20 74.3 0.0 3.5e-19 70.2 0.0 3.0 3 0 0 3 3 2 1 Zinc-binding dehydrogenase KAsynt_C_assoc PF16197.5 EXF85213.1 - 6.1e-20 71.8 0.0 1.5e-19 70.5 0.0 1.8 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension ADH_zinc_N PF00107.26 EXF85213.1 - 8.2e-16 58.2 0.0 4.2e-15 55.9 0.0 2.3 2 0 0 2 2 2 1 Zinc-binding dehydrogenase adh_short PF00106.25 EXF85213.1 - 2.4e-08 33.7 0.8 1e-07 31.6 0.9 2.1 2 0 0 2 2 2 1 short chain dehydrogenase PP-binding PF00550.25 EXF85213.1 - 1.1e-06 28.9 0.0 4.7e-06 26.9 0.0 2.2 1 0 0 1 1 1 1 Phosphopantetheine attachment site adh_short_C2 PF13561.6 EXF85213.1 - 0.0012 18.5 0.2 0.0037 16.9 0.2 1.9 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Methyltransf_23 PF13489.6 EXF85213.1 - 0.0027 17.6 0.0 0.007 16.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF85213.1 - 0.036 14.7 0.0 0.93 10.2 0.0 2.8 2 0 0 2 2 2 0 Methyltransferase domain p450 PF00067.22 EXF85214.1 - 4.3e-50 170.8 0.0 5.2e-25 88.1 0.0 2.1 2 0 0 2 2 2 2 Cytochrome P450 AMP-binding PF00501.28 EXF85215.1 - 6.5e-69 232.6 0.0 1e-68 231.9 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme FAD_binding_4 PF01565.23 EXF85215.1 - 1.1e-19 70.5 2.7 3.1e-19 69.1 2.7 1.8 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EXF85215.1 - 4.9e-10 39.4 0.2 1e-09 38.4 0.2 1.5 1 0 0 1 1 1 1 Berberine and berberine like AMP-binding_C PF13193.6 EXF85215.1 - 0.015 16.3 0.1 0.067 14.2 0.1 2.2 1 1 0 1 1 1 0 AMP-binding enzyme C-terminal domain Cytokin-bind PF09265.10 EXF85215.1 - 0.14 11.5 0.0 0.23 10.8 0.0 1.2 1 0 0 1 1 1 0 Cytokinin dehydrogenase 1, FAD and cytokinin binding adh_short PF00106.25 EXF85216.1 - 2.4e-16 59.8 0.1 7.5e-16 58.2 0.1 1.7 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF85216.1 - 5.5e-09 35.9 0.2 1e-08 35.1 0.1 1.4 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF85216.1 - 3e-05 24.0 0.1 4.9e-05 23.3 0.1 1.3 1 0 0 1 1 1 1 KR domain bZIP_1 PF00170.21 EXF85217.1 - 0.00019 21.5 5.0 0.00042 20.3 5.0 1.5 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EXF85217.1 - 0.00031 20.7 7.1 0.00065 19.7 7.1 1.5 1 0 0 1 1 1 1 Basic region leucine zipper LolA PF03548.15 EXF85218.1 - 0.027 14.2 0.0 0.033 13.9 0.0 1.1 1 0 0 1 1 1 0 Outer membrane lipoprotein carrier protein LolA Abhydrolase_1 PF00561.20 EXF85219.1 - 4.3e-25 88.8 0.3 7.3e-25 88.1 0.3 1.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EXF85219.1 - 1.8e-19 71.2 0.1 2.3e-19 70.9 0.1 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EXF85219.1 - 4.3e-08 32.7 0.0 2e-05 24.0 0.1 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Ndr PF03096.14 EXF85219.1 - 5e-06 25.4 0.0 8.3e-06 24.7 0.0 1.3 1 0 0 1 1 1 1 Ndr family Peptidase_S9 PF00326.21 EXF85219.1 - 0.0021 17.6 0.0 0.01 15.3 0.0 2.1 1 1 0 1 1 1 1 Prolyl oligopeptidase family Esterase_phd PF10503.9 EXF85219.1 - 0.05 13.1 0.0 0.8 9.1 0.0 2.4 3 0 0 3 3 3 0 Esterase PHB depolymerase QCR10 PF09796.9 EXF85219.1 - 0.054 13.5 0.1 0.73 9.9 0.0 2.3 2 0 0 2 2 2 0 Ubiquinol-cytochrome-c reductase complex subunit (QCR10) RNR_N PF08343.10 EXF85219.1 - 0.09 12.8 0.0 0.27 11.3 0.0 1.7 2 0 0 2 2 2 0 Ribonucleotide reductase N-terminal Abhydrolase_5 PF12695.7 EXF85219.1 - 0.14 12.0 0.0 0.35 10.6 0.0 1.7 1 0 0 1 1 1 0 Alpha/beta hydrolase family MFS_1 PF07690.16 EXF85220.1 - 4.1e-35 121.4 18.1 4.1e-35 121.4 18.1 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily DUF3040 PF11239.8 EXF85220.1 - 0.013 15.7 3.8 0.12 12.6 0.0 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3040) COesterase PF00135.28 EXF85221.1 - 2e-83 281.0 0.0 4.9e-76 256.6 0.0 2.0 1 1 1 2 2 2 2 Carboxylesterase family Abhydrolase_3 PF07859.13 EXF85221.1 - 2.3e-11 43.9 0.0 3.7e-11 43.3 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Sugar_tr PF00083.24 EXF85222.1 - 1e-37 130.1 30.1 1.2e-25 90.3 12.7 2.0 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 EXF85222.1 - 1.5e-19 70.2 39.6 1.2e-09 37.6 17.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Phage_holin_2_4 PF16082.5 EXF85222.1 - 0.027 14.2 0.1 0.027 14.2 0.1 2.6 2 1 1 3 3 3 0 Bacteriophage holin family, superfamily II-like PhoD PF09423.10 EXF85223.1 - 7.3e-39 133.8 2.9 2.7e-38 131.9 2.9 1.8 1 1 0 1 1 1 1 PhoD-like phosphatase Metallophos PF00149.28 EXF85223.1 - 0.0026 18.3 0.2 0.0039 17.7 0.2 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PhoD_N PF16655.5 EXF85223.1 - 0.084 13.4 0.0 0.21 12.2 0.0 1.6 1 0 0 1 1 1 0 PhoD-like phosphatase, N-terminal domain DUF4483 PF14825.6 EXF85224.1 - 0.0022 17.8 0.1 0.0027 17.5 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4483) DUF819 PF05684.12 EXF85224.1 - 0.083 11.9 0.1 0.096 11.7 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF819) Methyltransf_23 PF13489.6 EXF85225.1 - 6.5e-12 45.6 0.0 8.8e-12 45.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF85225.1 - 8.3e-11 42.5 0.1 2.1e-10 41.2 0.1 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF85225.1 - 5.6e-10 39.9 0.0 9.7e-10 39.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF85225.1 - 8.3e-08 32.8 0.0 1.6e-07 31.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF85225.1 - 8e-06 25.7 0.0 1.6e-05 24.7 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EXF85225.1 - 0.0018 17.7 0.0 0.0083 15.5 0.0 2.0 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family CheR PF01739.18 EXF85225.1 - 0.0073 15.8 0.0 0.072 12.6 0.0 2.1 1 1 1 2 2 2 1 CheR methyltransferase, SAM binding domain MetW PF07021.12 EXF85225.1 - 0.023 14.3 0.0 0.032 13.8 0.0 1.4 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW NodS PF05401.11 EXF85225.1 - 0.029 14.0 0.0 0.048 13.3 0.0 1.3 1 0 0 1 1 1 0 Nodulation protein S (NodS) Pox_MCEL PF03291.16 EXF85225.1 - 0.068 12.3 0.0 4.5 6.3 0.0 2.2 1 1 1 2 2 2 0 mRNA capping enzyme FtsJ PF01728.19 EXF85225.1 - 0.074 13.2 0.4 0.95 9.5 0.4 2.3 1 1 0 1 1 1 0 FtsJ-like methyltransferase BMC PF00936.19 EXF85225.1 - 0.11 12.5 0.4 0.27 11.3 0.1 1.8 2 0 0 2 2 2 0 BMC domain RCR PF12273.8 EXF85226.1 - 0.61 10.8 5.3 0.65 10.7 5.3 1.0 1 0 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red TRP PF06011.12 EXF85227.1 - 1.3e-142 475.5 35.9 1.7e-142 475.1 35.9 1.1 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.6 EXF85227.1 - 3e-37 128.1 0.4 5.2e-37 127.3 0.4 1.4 1 0 0 1 1 1 1 ML-like domain Fungal_trans_2 PF11951.8 EXF85228.1 - 3.3e-16 59.1 9.9 1.9e-14 53.3 9.9 2.4 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF85228.1 - 1e-05 25.6 11.1 1.8e-05 24.8 11.1 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Glyco_hydro_45 PF02015.16 EXF85230.1 - 1.5e-41 142.6 8.3 1.8e-41 142.4 8.3 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 45 Sfi1 PF08457.10 EXF85231.1 - 4.9e-35 121.1 37.9 1.1e-19 70.5 5.2 2.3 2 0 0 2 2 2 2 Sfi1 spindle body protein Rav1p_C PF12234.8 EXF85232.1 - 3.8e-256 851.6 0.8 4.4e-244 811.7 0.1 2.9 2 1 1 3 3 3 2 RAVE protein 1 C terminal OPT PF03169.15 EXF85232.1 - 5.5e-125 418.4 20.4 7.4e-125 417.9 20.4 1.1 1 0 0 1 1 1 1 OPT oligopeptide transporter protein DUF4968 PF16338.5 EXF85232.1 - 0.024 14.9 0.0 25 5.2 0.0 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4968) WD40 PF00400.32 EXF85232.1 - 0.057 14.3 4.4 22 6.1 0.0 5.0 5 0 0 5 5 5 0 WD domain, G-beta repeat Methyltransf_25 PF13649.6 EXF85233.1 - 8.9e-14 52.0 0.0 2.2e-13 50.7 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF85233.1 - 5.9e-12 46.1 0.0 1.7e-11 44.6 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EXF85233.1 - 1.4e-10 41.1 0.0 2.9e-10 40.0 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.6 EXF85233.1 - 1e-08 35.1 0.0 2.2e-08 34.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EXF85233.1 - 3.6e-06 26.9 0.0 9.6e-06 25.5 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF85233.1 - 3.7e-06 27.6 0.0 1.2e-05 25.9 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 EXF85233.1 - 7.3e-06 26.0 0.0 1.2e-05 25.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EXF85233.1 - 1.4e-05 24.7 0.1 2.4e-05 24.0 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase small domain RasGAP_C PF03836.15 EXF85233.1 - 0.0022 18.1 0.1 0.0036 17.4 0.1 1.3 1 0 0 1 1 1 1 RasGAP C-terminus Methyltransf_16 PF10294.9 EXF85233.1 - 0.0029 17.4 0.0 0.0069 16.1 0.0 1.6 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_9 PF08003.11 EXF85233.1 - 0.0037 16.3 0.0 0.0063 15.5 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) CMAS PF02353.20 EXF85233.1 - 0.014 14.7 0.0 0.024 14.0 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase TehB PF03848.14 EXF85233.1 - 0.028 13.8 0.1 0.044 13.2 0.1 1.3 1 0 0 1 1 1 0 Tellurite resistance protein TehB UPF0020 PF01170.18 EXF85233.1 - 0.036 13.7 0.0 0.098 12.3 0.0 1.7 2 0 0 2 2 2 0 Putative RNA methylase family UPF0020 Ubie_methyltran PF01209.18 EXF85233.1 - 0.039 13.3 0.1 0.063 12.6 0.1 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family PCMT PF01135.19 EXF85233.1 - 0.1 12.3 0.0 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Mito_fiss_reg PF05308.11 EXF85233.1 - 0.13 12.3 0.1 0.21 11.6 0.1 1.2 1 0 0 1 1 1 0 Mitochondrial fission regulator Uso1_p115_head PF04869.14 EXF85234.1 - 4.6e-119 397.2 0.0 1.2e-118 395.8 0.0 1.8 2 0 0 2 2 2 1 Uso1 / p115 like vesicle tethering protein, head region Uso1_p115_C PF04871.13 EXF85234.1 - 3.3e-17 63.0 30.6 3.3e-17 63.0 30.6 5.4 1 1 4 5 5 5 1 Uso1 / p115 like vesicle tethering protein, C terminal region TFIIA PF03153.13 EXF85234.1 - 0.00074 19.6 48.4 0.0012 18.9 48.4 1.3 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Apolipoprotein PF01442.18 EXF85234.1 - 0.0083 16.0 49.1 0.0083 16.0 49.1 3.6 1 1 2 3 3 3 1 Apolipoprotein A1/A4/E domain LMWPc PF01451.21 EXF85234.1 - 0.23 11.9 4.7 0.28 11.6 2.3 2.3 1 1 0 2 2 2 0 Low molecular weight phosphotyrosine protein phosphatase XRN_M PF17846.1 EXF85235.1 - 4.7e-137 457.6 0.2 1.9e-136 455.6 0.0 2.0 2 1 0 2 2 2 1 Xrn1 helical domain XRN_N PF03159.18 EXF85235.1 - 4.6e-99 330.8 0.0 8.1e-99 329.9 0.0 1.4 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus zf-CCHC_2 PF13696.6 EXF85235.1 - 0.12 12.2 2.2 0.29 11.0 2.2 1.6 1 0 0 1 1 1 0 Zinc knuckle RasGAP PF00616.19 EXF85237.1 - 5.8e-34 117.6 0.8 1.3e-20 74.0 0.0 3.0 2 1 1 3 3 3 2 GTPase-activator protein for Ras-like GTPase CRAL_TRIO_2 PF13716.6 EXF85237.1 - 3.8e-09 36.8 0.3 9.9e-09 35.5 0.3 1.6 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain Transket_pyr PF02779.24 EXF85238.1 - 4e-62 209.1 0.0 7.1e-62 208.2 0.0 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain E1_dh PF00676.20 EXF85238.1 - 1.3e-56 191.8 0.0 1.8e-56 191.3 0.0 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component OxoGdeHyase_C PF16870.5 EXF85238.1 - 3.2e-55 186.0 0.0 5.6e-55 185.2 0.0 1.4 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase C-terminal 2-oxogl_dehyd_N PF16078.5 EXF85238.1 - 6.8e-20 70.4 1.3 1.5e-19 69.3 1.3 1.6 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase N-terminus baeRF_family12 PF18856.1 EXF85238.1 - 0.17 12.5 0.3 0.56 10.8 0.0 2.0 2 0 0 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 12 YceG_bac PF14266.6 EXF85238.1 - 0.18 10.7 0.1 0.29 10.0 0.1 1.2 1 0 0 1 1 1 0 Putative component of 'biosynthetic module' BioY PF02632.14 EXF85238.1 - 0.21 11.6 0.2 0.36 10.9 0.2 1.2 1 0 0 1 1 1 0 BioY family zf-C2H2 PF00096.26 EXF85239.1 - 8.1e-23 79.6 21.8 1.5e-06 28.3 0.4 4.8 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EXF85239.1 - 1.8e-19 69.2 26.0 4.2e-09 36.4 1.0 5.0 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 EXF85239.1 - 3.5e-14 52.3 19.1 0.00023 21.7 0.5 4.7 4 0 0 4 4 4 4 C2H2-type zinc finger zf-met PF12874.7 EXF85239.1 - 8.7e-05 22.8 10.5 1.4 9.4 0.3 4.7 4 0 0 4 4 4 2 Zinc-finger of C2H2 type zf-H2C2_5 PF13909.6 EXF85239.1 - 0.00018 21.2 11.2 0.0026 17.5 0.2 3.6 3 0 0 3 3 3 2 C2H2-type zinc-finger domain FOXP-CC PF16159.5 EXF85239.1 - 0.00062 20.4 10.1 0.027 15.1 1.0 4.0 1 1 3 4 4 4 2 FOXP coiled-coil domain zf-C2H2_6 PF13912.6 EXF85239.1 - 0.0024 17.8 14.3 0.022 14.7 0.7 4.1 4 0 0 4 4 4 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EXF85239.1 - 0.0033 17.7 6.6 0.5 10.7 0.1 4.2 4 0 0 4 4 4 1 Zinc-finger double-stranded RNA-binding zf-C2H2_8 PF15909.5 EXF85239.1 - 0.0042 17.3 7.3 0.063 13.6 2.5 3.3 1 1 2 3 3 3 1 C2H2-type zinc ribbon zf-C2H2_11 PF16622.5 EXF85239.1 - 0.018 14.8 1.7 1.9 8.3 0.0 2.8 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-C2H2_aberr PF17017.5 EXF85239.1 - 0.022 14.9 6.7 3.3 7.8 0.2 3.4 1 1 3 4 4 4 0 Aberrant zinc-finger zf-LYAR PF08790.11 EXF85239.1 - 0.35 10.8 7.5 20 5.2 0.1 4.3 4 0 0 4 4 4 0 LYAR-type C2HC zinc finger zf-DNA_Pol PF08996.10 EXF85239.1 - 2.7 7.7 7.5 2 8.1 2.7 2.2 1 1 1 2 2 2 0 DNA Polymerase alpha zinc finger Microvir_J PF04726.13 EXF85240.1 - 0.028 14.4 0.2 0.079 13.0 0.2 1.8 1 0 0 1 1 1 0 Microvirus J protein Mito_carr PF00153.27 EXF85241.1 - 2.2e-61 203.8 3.0 2.3e-19 69.1 0.4 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Tom7 PF08038.12 EXF85242.1 - 1.5e-20 72.6 0.2 1.7e-20 72.4 0.2 1.0 1 0 0 1 1 1 1 TOM7 family DUF5049 PF16468.5 EXF85242.1 - 0.11 12.4 0.0 0.12 12.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5049) RRM_1 PF00076.22 EXF85243.1 - 1e-32 111.7 0.0 1.9e-15 56.4 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EXF85243.1 - 0.0015 18.6 0.0 0.0039 17.3 0.0 1.7 2 0 0 2 2 2 1 RNA recognition motif OB_RNB PF08206.11 EXF85243.1 - 0.0021 17.7 0.7 0.29 10.9 0.1 2.4 2 0 0 2 2 2 2 Ribonuclease B OB domain Nup35_RRM_2 PF14605.6 EXF85243.1 - 0.008 16.1 0.0 0.06 13.4 0.0 2.1 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif RRM_5 PF13893.6 EXF85243.1 - 0.049 13.2 0.0 0.17 11.5 0.0 1.8 1 1 1 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pet127 PF08634.10 EXF85244.1 - 3.1e-119 397.5 2.4 4.7e-119 396.9 2.4 1.3 1 0 0 1 1 1 1 Mitochondrial protein Pet127 Cohesin_load PF10345.9 EXF85245.1 - 7.7e-135 450.7 0.0 1e-134 450.2 0.0 1.0 1 0 0 1 1 1 1 Cohesin loading factor Abhydrolase_1 PF00561.20 EXF85246.1 - 1.4e-11 44.6 0.1 2.1e-10 40.7 0.1 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EXF85246.1 - 1.2e-08 34.5 0.0 4.2e-08 32.8 0.0 1.7 1 1 0 1 1 1 1 Serine aminopeptidase, S33 DUF4554 PF15091.6 EXF85247.1 - 2.9 6.7 8.6 4 6.2 8.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4554) DDHD PF02862.17 EXF85247.1 - 5.1 7.2 7.7 6.9 6.8 7.7 1.2 1 0 0 1 1 1 0 DDHD domain RR_TM4-6 PF06459.12 EXF85247.1 - 8.6 6.1 14.7 9.6 5.9 14.7 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 ArgJ PF01960.18 EXF85248.1 - 5.2e-149 496.1 0.2 5.9e-149 495.9 0.2 1.0 1 0 0 1 1 1 1 ArgJ family Acyl-CoA_dh_1 PF00441.24 EXF85249.1 - 1.8e-26 93.2 0.5 3e-26 92.4 0.5 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 EXF85249.1 - 7.4e-20 71.0 0.0 1.3e-19 70.2 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 EXF85249.1 - 4.9e-15 56.2 0.1 9.7e-15 55.2 0.1 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 EXF85249.1 - 1.2e-12 48.3 0.8 2.4e-12 47.3 0.8 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Spo12 PF05032.12 EXF85250.1 - 1.7e-15 56.6 0.7 5.1e-15 55.1 0.7 1.9 1 0 0 1 1 1 1 Spo12 family MRP-L51 PF10244.9 EXF85250.1 - 0.013 15.7 0.0 0.025 14.8 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial ribosomal subunit MMR_HSR1_Xtn PF16897.5 EXF85251.1 - 2.9e-35 120.5 2.1 6.8e-35 119.3 0.7 2.1 2 0 0 2 2 2 1 C-terminal region of MMR_HSR1 domain MMR_HSR1 PF01926.23 EXF85251.1 - 8.2e-21 74.2 0.0 2.2e-20 72.8 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase TGS PF02824.21 EXF85251.1 - 1.9e-19 69.4 0.1 3.4e-19 68.7 0.1 1.4 1 0 0 1 1 1 1 TGS domain FeoB_N PF02421.18 EXF85251.1 - 1.9e-12 47.0 0.0 3.1e-12 46.3 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EXF85251.1 - 5.2e-05 23.4 0.2 0.036 14.1 0.0 2.6 1 1 1 2 2 2 2 Dynamin family MeaB PF03308.16 EXF85251.1 - 0.072 12.1 0.2 0.2 10.6 0.1 1.8 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB ADH_N_2 PF16884.5 EXF85251.1 - 0.16 11.9 0.0 0.31 11.0 0.0 1.4 1 0 0 1 1 1 0 N-terminal domain of oxidoreductase Torus PF16131.5 EXF85252.1 - 5.6e-46 155.7 1.3 7.1e-46 155.4 0.1 1.8 2 0 0 2 2 2 1 Torus domain RRM_1 PF00076.22 EXF85252.1 - 7.2e-08 32.1 0.0 1.2e-07 31.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf_CCCH_4 PF18345.1 EXF85252.1 - 0.00013 21.8 0.6 0.00013 21.8 0.6 1.9 2 0 0 2 2 2 1 Zinc finger domain zf-CCCH PF00642.24 EXF85252.1 - 0.01 15.7 0.7 0.021 14.7 0.7 1.5 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Nup35_RRM_2 PF14605.6 EXF85252.1 - 0.03 14.3 0.0 0.061 13.3 0.0 1.5 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif NBD_C PF17042.5 EXF85252.1 - 0.43 11.1 4.6 0.67 10.4 0.0 2.5 3 0 0 3 3 3 0 Nucleotide-binding C-terminal domain Bacteriocin_IIc PF10439.9 EXF85254.1 - 0.22 11.7 2.7 0.32 11.1 2.7 1.2 1 0 0 1 1 1 0 Bacteriocin class II with double-glycine leader peptide Rep_fac_C PF08542.11 EXF85255.1 - 8.3e-23 80.6 0.0 2.5e-22 79.1 0.0 1.9 2 0 0 2 2 1 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.6 EXF85255.1 - 4.4e-12 46.1 0.0 1.1e-08 35.1 0.0 2.3 1 1 1 2 2 2 2 DNA polymerase III, delta subunit AAA PF00004.29 EXF85255.1 - 1.7e-11 44.7 0.0 3.5e-11 43.6 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 EXF85255.1 - 3.2e-07 30.4 0.0 7.4e-07 29.3 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EXF85255.1 - 2.2e-06 28.1 0.0 0.00018 21.9 0.0 2.4 1 1 1 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EXF85255.1 - 8.6e-05 22.8 0.1 0.22 11.8 0.0 2.6 1 1 1 2 2 2 2 AAA domain RuvB_N PF05496.12 EXF85255.1 - 9.3e-05 22.2 0.0 0.00021 21.1 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain Viral_helicase1 PF01443.18 EXF85255.1 - 0.00014 21.7 0.0 0.00024 20.9 0.0 1.3 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase AAA_3 PF07726.11 EXF85255.1 - 0.00029 20.7 0.0 0.00055 19.8 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta PF06144.13 EXF85255.1 - 0.0017 18.2 0.0 0.0028 17.5 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase III, delta subunit Mg_chelatase PF01078.21 EXF85255.1 - 0.0035 16.7 0.0 0.032 13.6 0.0 2.1 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI Rad17 PF03215.15 EXF85255.1 - 0.0044 17.0 0.0 0.0088 16.0 0.0 1.5 1 1 0 1 1 1 1 Rad17 P-loop domain AAA_assoc_2 PF16193.5 EXF85255.1 - 0.0053 17.1 0.0 0.019 15.3 0.0 2.0 2 0 0 2 2 1 1 AAA C-terminal domain MeaB PF03308.16 EXF85255.1 - 0.0055 15.7 0.0 0.0098 14.9 0.0 1.4 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_24 PF13479.6 EXF85255.1 - 0.0061 16.3 0.0 0.029 14.1 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 EXF85255.1 - 0.0096 15.7 0.0 0.014 15.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain TniB PF05621.11 EXF85255.1 - 0.011 15.1 0.0 3.8 6.9 0.0 2.3 2 0 0 2 2 2 0 Bacterial TniB protein DEAD PF00270.29 EXF85255.1 - 0.014 15.2 0.2 0.58 9.9 0.0 2.4 1 1 1 2 2 2 0 DEAD/DEAH box helicase AAA_19 PF13245.6 EXF85255.1 - 0.015 15.6 0.1 0.046 14.0 0.2 1.9 1 1 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 EXF85255.1 - 0.018 15.0 0.3 0.071 13.0 0.1 2.0 1 1 1 2 2 2 0 NTPase KTI12 PF08433.10 EXF85255.1 - 0.023 14.2 0.0 0.04 13.4 0.0 1.4 1 0 0 1 1 1 0 Chromatin associated protein KTI12 DNA_pol3_gamma3 PF12169.8 EXF85255.1 - 0.026 14.5 0.2 0.57 10.1 0.0 2.8 3 0 0 3 3 3 0 DNA polymerase III subunits gamma and tau domain III AAA_5 PF07728.14 EXF85255.1 - 0.054 13.5 0.2 0.51 10.3 0.1 2.5 3 1 0 3 3 3 0 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 EXF85255.1 - 0.09 12.3 0.1 0.68 9.5 0.1 2.2 2 1 1 3 3 3 0 AAA domain AAA_30 PF13604.6 EXF85255.1 - 0.092 12.5 0.1 0.26 11.0 0.1 1.7 1 1 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 EXF85256.1 - 2.2e-17 63.2 0.2 2.4e-15 56.6 0.0 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EXF85256.1 - 6.6e-08 32.2 0.4 5.7e-06 25.9 0.1 2.2 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EXF85256.1 - 3e-06 27.3 0.1 0.0013 18.6 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase SDA1 PF05285.12 EXF85256.1 - 0.0034 16.9 15.5 0.006 16.0 15.5 1.3 1 0 0 1 1 1 1 SDA1 RNA_pol_Rpc4 PF05132.14 EXF85256.1 - 0.0049 17.3 1.8 0.012 16.0 1.8 1.6 1 0 0 1 1 1 1 RNA polymerase III RPC4 AIG1 PF04548.16 EXF85256.1 - 0.0051 16.2 0.1 0.0092 15.3 0.1 1.4 1 0 0 1 1 1 1 AIG1 family SAPS PF04499.15 EXF85256.1 - 0.2 10.4 4.9 0.29 9.9 4.9 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein MCLC PF05934.11 EXF85256.1 - 0.37 9.5 2.6 0.57 8.9 2.6 1.2 1 0 0 1 1 1 0 Mid-1-related chloride channel (MCLC) eIF-3c_N PF05470.12 EXF85256.1 - 0.44 8.8 6.9 0.63 8.3 6.9 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus Presenilin PF01080.17 EXF85256.1 - 0.69 8.6 4.0 1 8.1 4.0 1.2 1 0 0 1 1 1 0 Presenilin Dynamin_N PF00350.23 EXF85256.1 - 0.7 9.9 10.9 0.14 12.2 0.7 3.7 3 1 1 4 4 4 0 Dynamin family Spore_coat_CotO PF14153.6 EXF85256.1 - 1.4 8.8 10.3 2.6 8.0 10.3 1.3 1 0 0 1 1 1 0 Spore coat protein CotO TRAP_alpha PF03896.16 EXF85256.1 - 1.5 8.0 5.6 2.6 7.2 5.6 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit FGF-BP1 PF06473.12 EXF85256.1 - 3 7.6 5.1 6.4 6.5 5.1 1.5 1 0 0 1 1 1 0 FGF binding protein 1 (FGF-BP1) LTV PF04180.14 EXF85257.1 - 6.3e-131 437.6 11.6 7.2e-131 437.4 11.6 1.0 1 0 0 1 1 1 1 Low temperature viability protein SAC3_GANP PF03399.16 EXF85258.1 - 7.4e-92 307.8 0.0 7.4e-92 307.8 0.0 1.6 2 0 0 2 2 2 1 SAC3/GANP family CSN8_PSD8_EIF3K PF10075.9 EXF85258.1 - 0.0023 17.9 0.0 0.0048 16.9 0.0 1.4 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family Glyco_hydro_43 PF04616.14 EXF85260.1 - 4.5e-24 85.3 0.0 5.3e-24 85.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 DKCLD PF08068.12 EXF85261.1 - 3.3e-30 103.9 0.1 6.9e-29 99.7 0.1 2.5 2 0 0 2 2 2 1 DKCLD (NUC011) domain TruB_N PF01509.18 EXF85261.1 - 1.1e-23 84.2 0.2 1.2e-20 74.3 0.2 3.3 1 1 0 1 1 1 1 TruB family pseudouridylate synthase (N terminal domain) TruB_C_2 PF16198.5 EXF85261.1 - 1.9e-22 79.2 0.6 3.4e-22 78.3 0.6 1.5 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain PUA PF01472.20 EXF85261.1 - 2.5e-22 78.6 1.1 5e-22 77.6 1.1 1.6 1 0 0 1 1 1 1 PUA domain UPF0113 PF03657.13 EXF85261.1 - 0.00053 20.2 0.0 0.0012 19.0 0.0 1.6 1 0 0 1 1 1 1 UPF0113 PUA domain Med19 PF10278.9 EXF85261.1 - 0.42 10.5 8.4 0.9 9.4 8.4 1.5 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 SKG6 PF08693.10 EXF85262.1 - 2.2 7.8 5.0 3.9 7.0 5.0 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain CN_hydrolase PF00795.22 EXF85263.1 - 9e-15 54.7 0.0 3.2e-13 49.6 0.0 2.2 2 0 0 2 2 2 2 Carbon-nitrogen hydrolase EphA2_TM PF14575.6 EXF85265.1 - 0.048 14.5 0.0 0.12 13.3 0.0 1.8 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF3481 PF11980.8 EXF85265.1 - 0.22 11.3 2.7 0.49 10.1 0.2 2.3 2 0 0 2 2 2 0 C-terminal domain of neuropilin glycoprotein COX14 PF14880.6 EXF85265.1 - 0.25 11.2 0.2 0.61 10.0 0.2 1.7 1 0 0 1 1 1 0 Cytochrome oxidase c assembly DER1 PF04511.15 EXF85266.1 - 1.4e-25 90.4 7.4 1.6e-25 90.1 7.4 1.0 1 0 0 1 1 1 1 Der1-like family DUF5090 PF17009.5 EXF85266.1 - 1.1 9.2 2.7 2 8.3 2.7 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF5090) IGPD PF00475.18 EXF85267.1 - 3.6e-60 202.4 0.3 5.2e-60 201.9 0.3 1.2 1 0 0 1 1 1 1 Imidazoleglycerol-phosphate dehydratase Cut12 PF11500.8 EXF85268.1 - 1.4e-47 161.3 21.6 1.4e-47 161.3 21.6 4.7 2 1 1 3 3 3 1 Spindle pole body formation-associated protein TSC22 PF01166.18 EXF85268.1 - 0.49 10.7 12.9 1.1 9.6 1.8 3.8 2 1 1 3 3 3 0 TSC-22/dip/bun family FlaC_arch PF05377.11 EXF85268.1 - 7.3 7.1 12.1 0.67 10.4 0.9 3.8 3 1 1 4 4 4 0 Flagella accessory protein C (FlaC) Fez1 PF06818.15 EXF85268.1 - 7.8 6.9 62.1 19 5.6 9.9 3.4 1 1 2 3 3 3 0 Fez1 HGTP_anticodon2 PF12745.7 EXF85269.1 - 2.1e-87 293.0 2.9 2.1e-87 293.0 2.9 2.7 3 0 0 3 3 3 1 Anticodon binding domain of tRNAs Pkinase PF00069.25 EXF85269.1 - 1.1e-74 251.1 0.0 7.2e-35 120.6 0.0 3.7 3 1 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 EXF85269.1 - 7.6e-48 163.0 0.0 6.3e-20 71.6 0.0 3.4 3 0 0 3 3 3 3 Protein tyrosine kinase tRNA-synt_His PF13393.6 EXF85269.1 - 2.8e-17 63.0 0.0 6.8e-17 61.7 0.0 1.7 1 0 0 1 1 1 1 Histidyl-tRNA synthetase RWD PF05773.22 EXF85269.1 - 2e-10 41.0 0.0 5.7e-10 39.5 0.0 1.9 1 0 0 1 1 1 1 RWD domain APH PF01636.23 EXF85269.1 - 2.7e-07 30.8 3.0 0.0062 16.5 0.1 3.3 3 0 0 3 3 3 2 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EXF85269.1 - 4.9e-07 28.9 0.7 0.0091 14.8 0.1 3.2 3 0 0 3 3 3 2 Fungal protein kinase Kinase-like PF14531.6 EXF85269.1 - 4.6e-05 22.9 0.0 0.0012 18.2 0.0 2.5 2 0 0 2 2 2 1 Kinase-like HGTP_anticodon PF03129.20 EXF85269.1 - 0.004 17.3 0.0 0.016 15.4 0.0 2.1 1 0 0 1 1 1 1 Anticodon binding domain YrbL-PhoP_reg PF10707.9 EXF85269.1 - 0.04 13.4 0.0 1.2 8.6 0.0 2.4 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL CDC45 PF02724.14 EXF85269.1 - 1.2 7.3 11.1 0.7 8.1 3.2 2.3 2 0 0 2 2 2 0 CDC45-like protein Med21 PF11221.8 EXF85269.1 - 1.3 9.3 9.2 0.051 13.8 2.7 2.1 2 0 0 2 2 1 0 Subunit 21 of Mediator complex PPP4R2 PF09184.11 EXF85269.1 - 4.5 6.8 15.3 0.7 9.4 6.6 2.4 2 0 0 2 2 2 0 PPP4R2 UQ_con PF00179.26 EXF85270.1 - 1.1e-30 106.1 0.0 2.3e-27 95.4 0.0 2.2 1 1 1 2 2 2 2 Ubiquitin-conjugating enzyme TGF_beta_GS PF08515.12 EXF85271.1 - 0.1 12.1 2.9 7.4 6.2 0.7 2.6 2 0 0 2 2 2 0 Transforming growth factor beta type I GS-motif Snapin_Pallidin PF14712.6 EXF85271.1 - 0.33 11.4 2.1 0.5 10.8 0.6 2.1 2 0 0 2 2 2 0 Snapin/Pallidin DnaJ_C PF01556.18 EXF85272.1 - 7.6e-38 129.9 0.6 1e-37 129.5 0.6 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EXF85272.1 - 4e-27 94.1 1.7 6.6e-27 93.4 1.7 1.4 1 0 0 1 1 1 1 DnaJ domain HAD_2 PF13419.6 EXF85273.1 - 1.4e-23 83.9 0.0 1.7e-23 83.6 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EXF85273.1 - 5.2e-12 46.5 0.1 2e-11 44.6 0.1 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EXF85273.1 - 9.2e-06 25.6 0.0 1.8e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like NIF PF03031.18 EXF85273.1 - 0.0018 18.0 0.0 0.03 14.1 0.0 2.1 1 1 0 1 1 1 1 NLI interacting factor-like phosphatase HAD PF12710.7 EXF85273.1 - 0.0038 17.7 0.0 0.0055 17.1 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 EXF85273.1 - 0.027 14.6 0.0 1.2 9.2 0.0 2.3 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase DnaG_DnaB_bind PF08278.11 EXF85273.1 - 0.13 12.9 0.0 0.17 12.5 0.0 1.2 1 0 0 1 1 1 0 DNA primase DnaG DnaB-binding Rit1_C PF17184.4 EXF85274.1 - 1.6e-109 365.5 0.0 2e-109 365.2 0.0 1.1 1 0 0 1 1 1 1 Rit1 N-terminal domain Init_tRNA_PT PF04179.12 EXF85274.1 - 2.4e-34 117.9 0.0 4.9e-34 117.0 0.0 1.5 1 0 0 1 1 1 1 Rit1 DUSP-like domain MARVEL PF01284.23 EXF85275.1 - 9.3e-06 25.7 9.9 1.6e-05 25.0 9.9 1.3 1 0 0 1 1 1 1 Membrane-associating domain DUF4281 PF14108.6 EXF85275.1 - 0.0001 22.7 2.4 0.00011 22.6 1.1 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF4281) Nop16 PF09420.10 EXF85276.1 - 1.4e-63 214.8 12.9 2.9e-58 197.4 3.4 2.0 2 0 0 2 2 2 2 Ribosome biogenesis protein Nop16 GFO_IDH_MocA PF01408.22 EXF85277.1 - 5e-11 43.5 0.5 2.2e-10 41.4 0.5 2.1 1 1 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold NAD_binding_3 PF03447.16 EXF85277.1 - 0.065 13.9 0.1 0.13 13.0 0.1 1.6 1 1 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain CoA_binding_2 PF13380.6 EXF85277.1 - 0.14 12.7 0.0 0.27 11.7 0.0 1.4 1 0 0 1 1 1 0 CoA binding domain DHDPS PF00701.22 EXF85278.1 - 5.8e-32 110.5 0.0 6.8e-32 110.3 0.0 1.1 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family DAO PF01266.24 EXF85279.1 - 1.2e-63 215.8 2.7 1.5e-63 215.5 2.7 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EXF85279.1 - 3.5e-06 26.5 0.0 0.0061 15.8 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EXF85279.1 - 2e-05 25.1 0.1 0.24 12.0 0.0 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EXF85279.1 - 3e-05 24.2 0.5 8.1e-05 22.8 0.5 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain MCRA PF06100.11 EXF85279.1 - 0.002 17.0 0.3 0.067 12.0 0.2 2.1 2 0 0 2 2 2 1 MCRA family Trp_halogenase PF04820.14 EXF85279.1 - 0.0031 16.4 0.3 0.0052 15.7 0.3 1.3 1 0 0 1 1 1 1 Tryptophan halogenase Thi4 PF01946.17 EXF85279.1 - 0.0052 16.1 0.0 0.0095 15.2 0.0 1.3 1 0 0 1 1 1 1 Thi4 family Sacchrp_dh_NADP PF03435.18 EXF85279.1 - 0.022 15.0 0.1 0.1 12.8 0.1 2.1 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain GMC_oxred_N PF00732.19 EXF85279.1 - 0.032 13.6 0.2 1.6 8.0 0.1 2.1 2 0 0 2 2 2 0 GMC oxidoreductase GSHPx PF00255.19 EXF85280.1 - 6.1e-42 141.6 0.1 7.6e-42 141.3 0.1 1.1 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.21 EXF85280.1 - 0.00022 21.1 0.0 0.00036 20.4 0.0 1.4 1 1 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EXF85280.1 - 0.00053 19.7 0.0 0.00078 19.2 0.0 1.2 1 0 0 1 1 1 1 Redoxin Band_7 PF01145.25 EXF85281.1 - 2.1e-30 106.1 0.4 5.2e-30 104.8 0.4 1.6 1 0 0 1 1 1 1 SPFH domain / Band 7 family Band_7_C PF16200.5 EXF85281.1 - 1.1e-22 79.9 0.6 1.1e-22 79.9 0.6 2.0 2 0 0 2 2 2 1 C-terminal region of band_7 UQ_con PF00179.26 EXF85281.1 - 1.9e-15 56.8 0.0 3.1e-15 56.0 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EXF85281.1 - 0.018 15.3 0.0 0.034 14.4 0.0 1.4 1 0 0 1 1 1 0 RWD domain Pox_A11 PF05061.13 EXF85281.1 - 0.041 13.2 0.2 0.064 12.5 0.2 1.3 1 0 0 1 1 1 0 Poxvirus A11 Protein DCB PF16213.5 EXF85282.1 - 8.4e-48 162.4 5.6 1.5e-46 158.3 3.5 2.9 2 0 0 2 2 2 1 Dimerisation and cyclophilin-binding domain of Mon2 Sec7_N PF12783.7 EXF85282.1 - 7e-42 143.0 6.7 1.2e-41 142.2 0.0 4.2 6 1 0 6 6 6 1 Guanine nucleotide exchange factor in Golgi transport N-terminal Mon2_C PF16206.5 EXF85282.1 - 1.8e-29 102.5 12.5 2.5e-21 75.6 2.6 4.2 3 1 0 3 3 3 3 C-terminal region of Mon2 protein DUF1981 PF09324.10 EXF85282.1 - 2.5e-07 30.4 0.9 0.0002 21.2 0.1 4.1 4 0 0 4 4 4 1 Domain of unknown function (DUF1981) DUF2398 PF09661.10 EXF85282.1 - 0.19 11.0 4.1 0.86 8.8 0.1 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2398) F_actin_bund_C PF18060.1 EXF85282.1 - 0.44 10.7 4.3 0.93 9.7 4.3 1.5 1 0 0 1 1 1 0 F actin bundling C terminal Nnf1 PF03980.14 EXF85283.1 - 3e-11 43.7 1.7 4e-11 43.3 0.5 1.7 1 1 0 2 2 2 1 Nnf1 TPR_MLP1_2 PF07926.12 EXF85283.1 - 0.00046 20.2 0.2 0.00065 19.8 0.2 1.2 1 0 0 1 1 1 1 TPR/MLP1/MLP2-like protein Snapin_Pallidin PF14712.6 EXF85283.1 - 0.0032 17.8 0.6 0.0038 17.6 0.6 1.1 1 0 0 1 1 1 1 Snapin/Pallidin Nsp1_C PF05064.13 EXF85283.1 - 0.069 13.0 0.2 0.094 12.5 0.2 1.2 1 0 0 1 1 1 0 Nsp1-like C-terminal region PH_9 PF15410.6 EXF85284.1 - 4.7e-07 30.2 0.0 7.3e-07 29.6 0.0 1.2 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 EXF85284.1 - 0.0048 17.4 0.1 0.0097 16.4 0.1 1.5 1 0 0 1 1 1 1 PH domain Imm53 PF15580.6 EXF85284.1 - 0.14 11.9 0.5 0.59 9.9 0.2 2.0 1 1 1 2 2 2 0 Immunity protein 53 NTF2 PF02136.20 EXF85285.1 - 3.2e-25 89.0 0.4 5.1e-25 88.4 0.4 1.3 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain RRM_1 PF00076.22 EXF85285.1 - 6e-05 22.8 0.1 0.0001 22.0 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 EXF85285.1 - 0.078 13.0 1.4 0.25 11.4 0.0 2.5 2 0 0 2 2 2 0 RNA binding motif DbpA PF03880.15 EXF85285.1 - 0.09 12.8 0.0 0.23 11.5 0.0 1.7 1 0 0 1 1 1 0 DbpA RNA binding domain Phosphodiest PF01663.22 EXF85286.1 - 5e-15 55.9 0.2 8.5e-15 55.2 0.2 1.4 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 EXF85286.1 - 2e-06 27.5 0.0 3.2e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 Sulfatase Metalloenzyme PF01676.18 EXF85286.1 - 0.00059 19.3 0.8 0.0017 17.8 0.8 1.7 2 0 0 2 2 2 1 Metalloenzyme superfamily Sugar_tr PF00083.24 EXF85287.1 - 1.6e-78 264.6 14.9 1.9e-78 264.4 14.9 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF85287.1 - 3.7e-14 52.4 22.1 3.7e-14 52.4 22.1 1.3 1 1 0 1 1 1 1 Major Facilitator Superfamily OppC_N PF12911.7 EXF85287.1 - 0.0044 17.0 1.7 0.012 15.5 0.2 2.5 2 0 0 2 2 2 1 N-terminal TM domain of oligopeptide transport permease C DUF2568 PF10823.8 EXF85287.1 - 2.5 8.4 12.0 6.4 7.1 0.6 3.9 3 1 0 3 3 3 0 Protein of unknown function (DUF2568) G-patch_2 PF12656.7 EXF85288.1 - 1.2e-14 54.1 1.2 1.2e-14 54.1 1.2 2.8 2 0 0 2 2 2 1 G-patch domain FAD_binding_6 PF00970.24 EXF85289.1 - 3.3e-30 104.4 0.0 5.5e-30 103.7 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 EXF85289.1 - 9.5e-27 93.8 0.0 1.4e-26 93.3 0.0 1.2 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 EXF85289.1 - 0.00022 21.4 0.0 0.023 14.8 0.0 2.2 2 0 0 2 2 2 1 Ferric reductase NAD binding domain FAD_binding_9 PF08021.11 EXF85289.1 - 0.12 12.6 0.0 0.25 11.6 0.0 1.5 1 0 0 1 1 1 0 Siderophore-interacting FAD-binding domain Pex16 PF08610.10 EXF85289.1 - 0.15 11.1 0.0 0.22 10.6 0.0 1.1 1 0 0 1 1 1 0 Peroxisomal membrane protein (Pex16) LRR_1 PF00560.33 EXF85291.1 - 0.21 12.2 13.4 28 5.8 0.1 6.9 6 0 0 6 6 6 0 Leucine Rich Repeat LRR_4 PF12799.7 EXF85291.1 - 3.9 8.0 19.2 7.5 7.1 1.3 4.9 5 1 0 5 5 5 0 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EXF85291.1 - 5.6 7.3 17.7 6.9 7.0 0.9 6.1 7 0 0 7 7 7 0 Leucine Rich repeat EF-hand_4 PF12763.7 EXF85292.1 - 5.3e-24 84.2 0.0 4.1e-12 46.0 0.0 2.4 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand DUF1720 PF08226.11 EXF85292.1 - 9.8e-07 29.1 105.7 8.6e-05 22.9 33.1 9.9 7 3 4 11 11 11 4 Domain of unknown function (DUF1720) EF-hand_1 PF00036.32 EXF85292.1 - 0.0011 18.4 0.0 0.96 9.2 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 EXF85292.1 - 0.0041 17.6 2.0 1.8 9.0 0.0 3.2 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 EXF85292.1 - 0.072 13.1 0.1 41 4.5 0.0 3.3 3 0 0 3 3 3 0 EF-hand domain E3_binding PF02817.17 EXF85292.1 - 0.36 11.2 0.0 0.36 11.2 0.0 2.4 2 0 0 2 2 2 0 e3 binding domain SAPS PF04499.15 EXF85293.1 - 1.3e-16 60.5 0.1 1.3e-16 60.5 0.1 2.0 2 1 0 2 2 2 1 SIT4 phosphatase-associated protein DUF1902 PF08972.11 EXF85293.1 - 0.11 12.5 0.7 14 5.8 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1902) P3A PF08727.11 EXF85294.1 - 7.9 6.0 7.0 2.7 7.4 0.1 2.9 2 0 0 2 2 2 0 Poliovirus 3A protein like Epimerase PF01370.21 EXF85295.1 - 4.2e-12 46.0 0.1 1.2e-11 44.5 0.1 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EXF85295.1 - 7.5e-11 41.6 0.0 1.4e-10 40.6 0.0 1.5 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 EXF85295.1 - 6.4e-09 35.6 0.0 1.7e-08 34.3 0.0 1.7 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 EXF85295.1 - 5.1e-08 33.0 0.0 8.1e-08 32.4 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding NAD_binding_4 PF07993.12 EXF85295.1 - 4.3e-07 29.4 0.0 4.6e-05 22.7 0.0 2.1 2 0 0 2 2 2 2 Male sterility protein NmrA PF05368.13 EXF85295.1 - 4.9e-07 29.6 0.0 7.6e-07 28.9 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family Polysacc_synt_2 PF02719.15 EXF85295.1 - 0.011 14.9 0.0 0.018 14.2 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein GCFC PF07842.12 EXF85296.1 - 1.2e-66 225.2 3.9 2.3e-66 224.3 3.9 1.5 1 0 0 1 1 1 1 GC-rich sequence DNA-binding factor-like protein G-patch PF01585.23 EXF85296.1 - 3e-15 55.8 2.4 8.8e-15 54.3 2.4 1.9 1 0 0 1 1 1 1 G-patch domain TIP_N PF12457.8 EXF85296.1 - 2.1e-14 53.7 13.0 2.1e-14 53.7 13.0 3.3 2 2 2 4 4 4 1 Tuftelin interacting protein N terminal G-patch_2 PF12656.7 EXF85296.1 - 1.3e-07 31.6 1.3 1.3e-07 31.6 1.3 2.7 3 0 0 3 3 3 1 G-patch domain ATP-synt_E PF05680.12 EXF85296.1 - 1.6 9.1 8.1 7.2 7.0 8.1 2.1 1 0 0 1 1 1 0 ATP synthase E chain Cyt-b5 PF00173.28 EXF85297.1 - 2.6e-15 56.3 0.0 7.4e-15 54.9 0.0 1.8 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain FAD_binding_1 PF00667.20 EXF85297.1 - 2.4e-09 37.1 0.0 1.2e-08 34.8 0.0 2.2 1 1 0 1 1 1 1 FAD binding domain IDO PF01231.18 EXF85297.1 - 5.6e-09 35.3 0.0 3.8e-08 32.5 0.0 2.1 2 0 0 2 2 2 1 Indoleamine 2,3-dioxygenase NAD_binding_1 PF00175.21 EXF85297.1 - 3.5e-08 34.0 0.0 8.4e-08 32.8 0.0 1.7 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain zf-LITAF-like PF10601.9 EXF85298.1 - 1.8e-21 76.2 4.0 2.3e-21 75.8 4.0 1.1 1 0 0 1 1 1 1 LITAF-like zinc ribbon domain zf-ISL3 PF14690.6 EXF85298.1 - 0.94 10.2 4.4 13 6.5 0.8 2.3 2 0 0 2 2 2 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 zf-Mss51 PF13824.6 EXF85298.1 - 5 7.3 8.6 35 4.6 8.6 2.5 1 1 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 WD40 PF00400.32 EXF85299.1 - 1e-50 168.6 17.4 2e-08 34.8 0.5 8.6 8 1 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EXF85299.1 - 1.3e-10 41.4 0.1 0.0021 18.3 0.0 4.4 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EXF85299.1 - 1.7e-08 33.6 0.0 0.00069 18.4 0.0 4.1 5 0 0 5 5 5 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 EXF85299.1 - 3.5e-05 22.7 0.0 0.063 12.0 0.0 3.1 3 0 0 3 3 3 2 Nup133 N terminal like CLASP_N PF12348.8 EXF85300.1 - 1.9e-06 27.6 0.0 0.00027 20.6 0.0 2.3 2 0 0 2 2 2 1 CLASP N terminal HEAT PF02985.22 EXF85300.1 - 2.1e-05 24.4 0.7 1.9 9.0 0.1 4.6 4 0 0 4 4 4 1 HEAT repeat Cnd1 PF12717.7 EXF85300.1 - 8.1e-05 22.7 0.1 0.024 14.7 0.1 2.3 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EXF85300.1 - 0.00038 20.8 2.4 0.09 13.2 0.1 3.5 3 2 0 3 3 2 1 HEAT repeats Adaptin_N PF01602.20 EXF85300.1 - 0.033 12.8 0.2 2.2 6.7 0.0 2.6 2 1 0 2 2 2 0 Adaptin N terminal region TAN PF11640.8 EXF85300.1 - 0.1 12.7 1.8 0.11 12.7 0.1 1.9 2 0 0 2 2 2 0 Telomere-length maintenance and DNA damage repair DUF4763 PF15960.5 EXF85300.1 - 0.14 11.5 2.9 0.11 11.8 0.8 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4763) Jnk-SapK_ap_N PF09744.9 EXF85300.1 - 0.54 10.5 12.2 1.5 9.0 12.2 1.7 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 HALZ PF02183.18 EXF85300.1 - 0.8 10.0 8.7 1.7 8.9 1.2 2.9 3 0 0 3 3 2 0 Homeobox associated leucine zipper HEAT_EZ PF13513.6 EXF85300.1 - 0.83 10.2 4.1 1.8 9.2 0.6 3.2 4 0 0 4 4 2 0 HEAT-like repeat APG6_N PF17675.1 EXF85300.1 - 1.2 9.6 11.8 7.6 7.1 11.7 2.3 1 1 0 1 1 1 0 Apg6 coiled-coil region HAUS-augmin3 PF14932.6 EXF85300.1 - 1.6 8.3 8.0 8.4 5.9 8.0 2.0 1 1 0 1 1 1 0 HAUS augmin-like complex subunit 3 Spc7 PF08317.11 EXF85300.1 - 1.6 7.5 8.8 0.95 8.3 5.3 1.9 1 1 0 1 1 1 0 Spc7 kinetochore protein ADIP PF11559.8 EXF85300.1 - 1.7 8.7 11.8 5.1 7.2 11.8 1.8 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding KLRAQ PF10205.9 EXF85300.1 - 2.1 8.7 7.5 20 5.5 2.1 2.8 1 1 1 2 2 2 0 Predicted coiled-coil domain-containing protein Mod_r PF07200.13 EXF85300.1 - 2.1 8.4 8.3 6 7.0 8.3 1.8 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein PRKG1_interact PF15898.5 EXF85300.1 - 2.4 9.1 15.3 1.4 9.8 12.0 2.3 2 0 0 2 2 1 0 cGMP-dependent protein kinase interacting domain CorA PF01544.18 EXF85300.1 - 3 7.1 8.9 5.6 6.2 8.9 1.3 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein SHE3 PF17078.5 EXF85300.1 - 4.8 6.8 10.5 9.5 5.9 10.5 1.4 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 DUF1640 PF07798.11 EXF85300.1 - 5.1 7.1 16.4 2.4 8.2 1.1 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF1640) YabA PF06156.13 EXF85300.1 - 5.7 7.6 6.8 57 4.4 6.8 2.5 1 1 0 1 1 1 0 Initiation control protein YabA DUF3584 PF12128.8 EXF85300.1 - 6.5 4.1 9.8 12 3.3 9.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) MRP-L46 PF11788.8 EXF85300.1 - 6.9 7.4 7.2 1.8 9.3 3.0 2.1 2 0 0 2 2 1 0 39S mitochondrial ribosomal protein L46 Fez1 PF06818.15 EXF85300.1 - 7.6 6.9 10.7 2.8 8.3 7.7 1.8 2 0 0 2 2 1 0 Fez1 Ras PF00071.22 EXF85302.1 - 1e-05 25.2 0.0 2.6e-05 23.9 0.0 1.7 1 0 0 1 1 1 1 Ras family Helo_like_N PF17111.5 EXF85302.1 - 0.017 14.5 0.1 0.027 13.8 0.1 1.4 1 0 0 1 1 1 0 Fungal N-terminal domain of STAND proteins Roc PF08477.13 EXF85302.1 - 0.17 12.1 0.0 0.38 11.0 0.0 1.7 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase EthD PF07110.11 EXF85304.1 - 3.1e-22 79.5 0.1 5.3e-22 78.8 0.1 1.4 1 0 0 1 1 1 1 EthD domain MmlI PF09448.10 EXF85304.1 - 5e-07 30.2 0.2 2.6e-06 27.9 0.2 1.9 1 1 0 1 1 1 1 Methylmuconolactone methyl-isomerase COesterase PF00135.28 EXF85305.1 - 4.3e-62 210.6 0.2 5.5e-62 210.3 0.2 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EXF85305.1 - 0.0015 18.4 1.2 0.0027 17.6 0.2 1.9 2 0 0 2 2 2 1 alpha/beta hydrolase fold DUF2384 PF09722.10 EXF85305.1 - 0.066 13.3 0.0 0.31 11.1 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2384) Arginase PF00491.21 EXF85306.1 - 1.3e-88 297.2 0.0 1.5e-88 297.0 0.0 1.0 1 0 0 1 1 1 1 Arginase family AA_permease PF00324.21 EXF85307.1 - 2.4e-116 389.2 37.1 3.2e-116 388.7 37.1 1.1 1 0 0 1 1 1 1 Amino acid permease ApbA_C PF08546.11 EXF85307.1 - 4.4e-33 114.1 0.0 8e-33 113.3 0.0 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal AA_permease_2 PF13520.6 EXF85307.1 - 1.1e-30 106.9 42.2 1.3e-30 106.6 42.2 1.1 1 0 0 1 1 1 1 Amino acid permease ApbA PF02558.16 EXF85307.1 - 6.2e-27 94.1 0.0 1e-26 93.4 0.0 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA DUF2252 PF10009.9 EXF85307.1 - 0.0046 16.1 0.0 0.0069 15.5 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2252) NAD_binding_7 PF13241.6 EXF85307.1 - 0.02 15.4 0.0 0.042 14.3 0.0 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding PglD_N PF17836.1 EXF85307.1 - 0.026 15.2 0.0 0.055 14.1 0.0 1.5 1 0 0 1 1 1 0 PglD N-terminal domain GFO_IDH_MocA PF01408.22 EXF85307.1 - 0.066 14.0 0.0 0.14 13.0 0.0 1.5 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold DAO PF01266.24 EXF85307.1 - 0.067 12.8 0.4 0.14 11.7 0.0 1.7 2 0 0 2 2 2 0 FAD dependent oxidoreductase Shikimate_DH PF01488.20 EXF85307.1 - 0.16 12.0 0.0 0.71 9.9 0.0 1.9 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase IlvN PF07991.12 EXF85307.1 - 0.17 11.5 0.1 0.28 10.7 0.1 1.3 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain Aldolase_II PF00596.21 EXF85310.1 - 1.7e-46 158.5 0.2 2.2e-46 158.1 0.2 1.2 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain CDCA PF18484.1 EXF85310.1 - 0.16 11.8 0.2 0.31 10.9 0.2 1.4 1 0 0 1 1 1 0 Cadmium carbonic anhydrase repeat TauD PF02668.16 EXF85311.1 - 9.7e-32 110.8 0.2 1.4e-31 110.3 0.2 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Fungal_trans_2 PF11951.8 EXF85312.1 - 9.8e-53 179.3 4.1 1.3e-52 178.9 4.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Proton_antipo_M PF00361.20 EXF85312.1 - 0.08 12.1 0.2 0.15 11.3 0.2 1.3 1 0 0 1 1 1 0 Proton-conducting membrane transporter MFS_1 PF07690.16 EXF85313.1 - 1.2e-30 106.7 26.5 3e-29 102.1 25.6 2.6 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF85313.1 - 8.6e-11 41.4 13.6 8.6e-11 41.4 13.6 1.9 2 0 0 2 2 2 1 Sugar (and other) transporter OATP PF03137.20 EXF85313.1 - 0.05 11.9 6.0 0.0097 14.2 1.8 1.9 2 1 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family Beta-lactamase PF00144.24 EXF85314.1 - 4.2e-52 177.4 0.4 5.5e-52 177.1 0.4 1.1 1 0 0 1 1 1 1 Beta-lactamase Beta-lactamase2 PF13354.6 EXF85314.1 - 0.0012 18.5 0.0 0.74 9.4 0.0 2.2 2 0 0 2 2 2 2 Beta-lactamase enzyme family SET PF00856.28 EXF85315.1 - 5.1e-06 27.0 0.0 9.2e-06 26.1 0.0 1.4 1 0 0 1 1 1 1 SET domain Hydrolase_4 PF12146.8 EXF85316.1 - 0.14 11.4 0.0 3.2 7.0 0.0 2.1 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Methyltransf_23 PF13489.6 EXF85317.1 - 3.8e-19 69.1 0.0 9.4e-19 67.8 0.0 1.6 1 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF85317.1 - 2.5e-13 50.5 0.0 4.7e-13 49.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF85317.1 - 2.8e-13 50.4 0.0 6.5e-13 49.2 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF85317.1 - 4.7e-07 29.7 0.0 4.1e-06 26.7 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF85317.1 - 1.1e-05 26.1 0.0 6.6e-05 23.6 0.0 2.2 2 1 0 2 2 1 1 Methyltransferase domain Methyltransf_2 PF00891.18 EXF85317.1 - 0.0012 18.1 0.0 0.002 17.4 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain Ubie_methyltran PF01209.18 EXF85317.1 - 0.0018 17.7 0.0 0.0077 15.6 0.0 1.8 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family FtsJ PF01728.19 EXF85317.1 - 0.0043 17.2 0.0 0.038 14.1 0.0 2.0 2 0 0 2 2 2 1 FtsJ-like methyltransferase Methyltransf_4 PF02390.17 EXF85317.1 - 0.0079 15.7 0.0 0.016 14.7 0.0 1.5 1 0 0 1 1 1 1 Putative methyltransferase MTS PF05175.14 EXF85317.1 - 0.023 14.3 0.0 0.04 13.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain CMAS PF02353.20 EXF85317.1 - 0.036 13.4 0.0 0.063 12.6 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase PrmA PF06325.13 EXF85317.1 - 0.046 13.1 0.0 0.066 12.6 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Glycos_transf_1 PF00534.20 EXF85318.1 - 1.2e-19 70.5 0.0 2.6e-19 69.4 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EXF85318.1 - 1.6e-13 51.2 0.0 2.7e-13 50.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 EXF85318.1 - 0.044 14.2 0.0 0.16 12.4 0.0 1.9 2 0 0 2 2 2 0 Glycosyl transferases group 1 NAD_binding_1 PF00175.21 EXF85320.1 - 3.2e-10 40.6 0.0 5.8e-10 39.8 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Globin PF00042.22 EXF85320.1 - 4.1e-10 40.2 0.0 6.4e-10 39.6 0.0 1.3 1 0 0 1 1 1 1 Globin NAD_binding_6 PF08030.12 EXF85320.1 - 1.2e-05 25.4 0.0 4e-05 23.8 0.0 1.7 1 1 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_6 PF00970.24 EXF85320.1 - 1.3e-05 25.5 0.0 2.4e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain Protoglobin PF11563.8 EXF85320.1 - 0.00076 19.4 0.1 0.0013 18.6 0.1 1.4 1 0 0 1 1 1 1 Protoglobin Zn_clus PF00172.18 EXF85321.1 - 1.3e-05 25.2 11.5 2.4e-05 24.3 11.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ketoacyl-synt PF00109.26 EXF85322.1 - 9.2e-75 251.5 0.0 2e-74 250.4 0.0 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.10 EXF85322.1 - 5e-46 156.9 0.0 9.6e-46 155.9 0.0 1.5 1 0 0 1 1 1 1 KR domain PS-DH PF14765.6 EXF85322.1 - 2.5e-45 155.0 0.0 3.8e-45 154.4 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 EXF85322.1 - 5.8e-45 154.2 0.0 1.1e-44 153.3 0.0 1.3 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EXF85322.1 - 1.5e-29 102.4 1.9 1.6e-29 102.4 0.1 2.1 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain adh_short PF00106.25 EXF85322.1 - 3.8e-11 42.8 0.0 1e-10 41.4 0.0 1.8 1 0 0 1 1 1 1 short chain dehydrogenase KAsynt_C_assoc PF16197.5 EXF85322.1 - 1.1e-09 38.8 0.0 2.7e-09 37.4 0.0 1.7 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension adh_short_C2 PF13561.6 EXF85322.1 - 0.00013 21.6 0.0 0.00031 20.4 0.0 1.6 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Thiolase_N PF00108.23 EXF85322.1 - 0.00041 19.8 0.1 0.00078 18.9 0.1 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain Methyltransf_31 PF13847.6 EXF85322.1 - 0.035 13.9 0.0 0.086 12.6 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain PP-binding PF00550.25 EXF85322.1 - 0.073 13.4 0.0 0.23 11.9 0.0 1.9 1 0 0 1 1 1 0 Phosphopantetheine attachment site CBM_1 PF00734.18 EXF85323.1 - 1.9e-11 43.7 15.9 1.9e-11 43.7 15.9 2.8 3 0 0 3 3 3 1 Fungal cellulose binding domain Lipase_GDSL_2 PF13472.6 EXF85323.1 - 2e-07 31.6 3.1 3.4e-07 30.8 2.9 1.5 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EXF85323.1 - 0.00019 21.4 0.0 0.00027 21.0 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase MGC-24 PF05283.11 EXF85323.1 - 0.55 10.7 7.2 1.4 9.4 7.2 1.6 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin Acetyltransf_1 PF00583.25 EXF85325.1 - 2.2e-11 44.0 0.0 2.7e-11 43.7 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EXF85325.1 - 1.3e-09 38.0 0.0 2.1e-09 37.4 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EXF85325.1 - 3.8e-08 33.6 0.0 5.7e-08 33.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain NMT PF01233.19 EXF85325.1 - 0.00086 19.2 0.0 0.0012 18.7 0.0 1.2 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain FR47 PF08445.10 EXF85325.1 - 0.0031 17.4 0.0 0.005 16.8 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.6 EXF85325.1 - 0.0094 16.1 0.0 0.017 15.2 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_3 PF13302.7 EXF85325.1 - 0.015 16.0 0.0 0.017 15.8 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EXF85325.1 - 0.074 13.1 0.0 0.099 12.7 0.0 1.4 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain EFG_II PF14492.6 EXF85325.1 - 0.099 12.8 0.0 0.22 11.6 0.0 1.6 2 0 0 2 2 2 0 Elongation Factor G, domain II Acetyltransf_13 PF13880.6 EXF85325.1 - 0.11 12.5 0.1 0.35 10.9 0.0 1.8 2 1 0 2 2 2 0 ESCO1/2 acetyl-transferase RTC_insert PF05189.13 EXF85325.1 - 0.11 13.0 0.0 0.16 12.5 0.0 1.2 1 0 0 1 1 1 0 RNA 3'-terminal phosphate cyclase (RTC), insert domain Amelin PF05111.12 EXF85326.1 - 0.033 13.3 0.1 0.034 13.3 0.1 1.1 1 0 0 1 1 1 0 Ameloblastin precursor (Amelin) Peptidase_M20 PF01546.28 EXF85328.1 - 8.1e-32 110.6 0.0 1.1e-31 110.2 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EXF85328.1 - 5.6e-05 23.0 0.0 0.00012 21.9 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 EXF85328.1 - 0.014 15.0 0.0 0.025 14.2 0.0 1.4 1 0 0 1 1 1 0 Peptidase family M28 Fungal_lectin PF07938.12 EXF85329.1 - 6.4e-06 25.8 0.7 0.0092 15.4 0.1 2.5 2 1 0 2 2 2 2 Fungal fucose-specific lectin Autoind_bind PF03472.15 EXF85329.1 - 0.081 12.4 0.0 0.15 11.5 0.0 1.4 1 0 0 1 1 1 0 Autoinducer binding domain WW PF00397.26 EXF85330.1 - 8.2e-13 48.2 1.1 2.7e-12 46.5 1.1 2.0 1 0 0 1 1 1 1 WW domain SH3_19 PF18597.1 EXF85330.1 - 7 6.6 7.7 19 5.2 0.3 3.2 3 0 0 3 3 3 0 Myosin X N-terminal SH3 domain Methyltransf_23 PF13489.6 EXF85331.1 - 1.2e-20 74.0 0.0 1.9e-20 73.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF85331.1 - 3e-09 37.5 0.0 7e-09 36.3 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF85331.1 - 3.8e-07 30.0 0.1 8.6e-06 25.6 0.1 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF85331.1 - 7.8e-07 29.7 0.0 1.6e-06 28.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF85331.1 - 1.8e-06 28.6 0.0 1.8e-05 25.4 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EXF85331.1 - 0.007 15.9 0.0 0.012 15.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 EXF85331.1 - 0.0076 15.7 0.0 0.013 14.9 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_2 PF00891.18 EXF85331.1 - 0.07 12.4 0.0 0.097 12.0 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase domain Peptidase_C23 PF05379.11 EXF85332.1 - 0.00031 20.8 0.0 0.00064 19.8 0.0 1.5 1 0 0 1 1 1 1 Carlavirus endopeptidase MTCP1 PF08991.10 EXF85333.1 - 0.084 13.1 0.1 0.12 12.7 0.1 1.2 1 0 0 1 1 1 0 Mature-T-Cell Proliferation I type CX9C PF16860.5 EXF85333.1 - 0.094 12.7 0.2 0.14 12.2 0.2 1.2 1 0 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, GerE PF00196.19 EXF85333.1 - 0.2 11.2 0.0 0.41 10.2 0.0 1.4 1 0 0 1 1 1 0 Bacterial regulatory proteins, luxR family PH_10 PF15411.6 EXF85334.1 - 5.6e-41 139.7 0.2 1.2e-40 138.6 0.2 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain CDC24 PF06395.11 EXF85334.1 - 2.9e-32 110.8 0.0 6.3e-32 109.7 0.0 1.6 1 0 0 1 1 1 1 CDC24 Calponin RhoGEF PF00621.20 EXF85334.1 - 3.4e-29 102.4 0.0 5.5e-29 101.7 0.0 1.4 1 0 0 1 1 1 1 RhoGEF domain PB1 PF00564.24 EXF85334.1 - 2.2e-08 33.9 0.0 5.1e-08 32.7 0.0 1.6 1 0 0 1 1 1 1 PB1 domain DUF5319 PF17252.2 EXF85334.1 - 0.17 12.2 0.3 0.56 10.5 0.0 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5319) WD40 PF00400.32 EXF85335.1 - 7.2e-29 99.4 6.7 9.1e-05 23.2 0.0 6.9 6 0 0 6 6 6 6 WD domain, G-beta repeat F-box-like PF12937.7 EXF85335.1 - 1.9e-11 43.7 1.4 3.4e-11 42.9 0.3 2.0 2 0 0 2 2 2 1 F-box-like ANAPC4_WD40 PF12894.7 EXF85335.1 - 5.7e-06 26.5 0.3 0.036 14.3 0.0 4.0 3 2 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain F-box PF00646.33 EXF85335.1 - 0.00019 21.2 0.3 0.00053 19.8 0.1 1.8 2 0 0 2 2 2 1 F-box domain Nup160 PF11715.8 EXF85335.1 - 0.0007 18.4 0.1 0.16 10.6 0.0 2.4 2 0 0 2 2 2 2 Nucleoporin Nup120/160 WD40_like PF17005.5 EXF85335.1 - 0.0057 16.0 0.3 0.046 13.0 0.1 2.3 2 1 0 2 2 2 1 WD40-like domain F-box_4 PF15966.5 EXF85335.1 - 0.0079 16.1 0.0 0.024 14.5 0.0 1.8 1 0 0 1 1 1 1 F-box MgtE_N PF03448.17 EXF85335.1 - 0.13 12.9 0.0 0.37 11.4 0.0 1.7 1 0 0 1 1 1 0 MgtE intracellular N domain Snf7 PF03357.21 EXF85336.1 - 1.6e-44 151.5 14.5 1.9e-44 151.3 14.5 1.1 1 0 0 1 1 1 1 Snf7 NPV_P10 PF05531.12 EXF85336.1 - 0.0021 18.4 9.1 1.2 9.7 0.1 3.2 2 1 0 2 2 2 2 Nucleopolyhedrovirus P10 protein Mod_r PF07200.13 EXF85336.1 - 0.0072 16.4 7.2 0.0072 16.4 7.2 2.0 1 1 1 2 2 2 1 Modifier of rudimentary (Mod(r)) protein CENP-F_leu_zip PF10473.9 EXF85336.1 - 0.038 14.0 11.2 2.3 8.3 9.2 2.6 2 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 FapA PF03961.13 EXF85336.1 - 0.057 12.0 9.8 0.38 9.3 3.8 2.0 1 1 1 2 2 2 0 Flagellar Assembly Protein A Alpha-2-MRAP_C PF06401.11 EXF85336.1 - 0.075 13.0 5.7 0.58 10.1 5.2 2.1 1 1 1 2 2 2 0 Alpha-2-macroglobulin RAP, C-terminal domain Prefoldin PF02996.17 EXF85336.1 - 0.08 12.9 9.2 2.5 8.0 0.1 3.6 3 1 1 4 4 4 0 Prefoldin subunit CLZ PF16526.5 EXF85336.1 - 0.17 12.3 10.0 0.51 10.7 0.0 3.7 3 1 1 4 4 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF4844 PF16133.5 EXF85336.1 - 0.27 11.8 4.3 1.5 9.4 4.3 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4844) Endotoxin_N PF03945.14 EXF85336.1 - 0.28 10.9 6.8 0.46 10.2 0.6 2.1 1 1 1 2 2 2 0 delta endotoxin, N-terminal domain DUF848 PF05852.11 EXF85336.1 - 0.28 11.3 6.0 0.33 11.1 4.6 1.8 1 1 1 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) ING PF12998.7 EXF85336.1 - 0.33 11.6 6.3 0.38 11.4 4.2 2.0 1 1 1 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding Muted PF14942.6 EXF85336.1 - 0.6 10.4 9.9 3.6 7.9 5.9 2.4 1 1 1 2 2 2 0 Organelle biogenesis, Muted-like protein FlxA PF14282.6 EXF85336.1 - 0.64 10.0 14.2 0.59 10.1 12.4 1.8 1 1 0 1 1 1 0 FlxA-like protein DUF4407 PF14362.6 EXF85336.1 - 0.91 8.8 8.6 1.5 8.1 8.6 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) CorA PF01544.18 EXF85336.1 - 1.1 8.5 4.8 15 4.8 4.4 2.0 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein DUF4337 PF14235.6 EXF85336.1 - 1.3 9.1 8.2 5.6 7.1 2.7 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4337) Atg14 PF10186.9 EXF85336.1 - 1.4 7.9 9.3 3.4 6.7 9.1 1.6 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF2205 PF10224.9 EXF85336.1 - 1.5 8.9 7.9 0.35 10.9 2.6 2.6 2 1 1 3 3 3 0 Short coiled-coil protein DASH_Dam1 PF08653.10 EXF85336.1 - 1.7 8.5 4.7 11 5.9 0.1 3.3 3 0 0 3 3 3 0 DASH complex subunit Dam1 FlaC_arch PF05377.11 EXF85336.1 - 1.7 9.1 12.1 3.5 8.1 0.1 3.9 2 1 2 4 4 3 0 Flagella accessory protein C (FlaC) FUSC PF04632.12 EXF85336.1 - 2.8 6.4 3.3 5.3 5.4 0.6 1.8 1 1 1 2 2 2 0 Fusaric acid resistance protein family DUF4446 PF14584.6 EXF85336.1 - 3.1 7.8 8.4 5.1 7.1 1.8 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF4446) Uso1_p115_C PF04871.13 EXF85336.1 - 5.2 7.5 18.7 1.3e+02 2.9 17.6 2.6 1 1 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region TMPIT PF07851.13 EXF85336.1 - 7 5.8 8.8 7.8 5.6 6.5 1.8 1 1 1 2 2 2 0 TMPIT-like protein Ion_trans PF00520.31 EXF85337.1 - 0.00047 19.5 16.4 0.012 14.8 18.1 2.3 1 1 1 2 2 2 1 Ion transport protein PKD_channel PF08016.12 EXF85337.1 - 0.6 8.7 11.5 1.4 7.5 1.6 2.3 2 0 0 2 2 2 0 Polycystin cation channel DUF1961 PF09224.11 EXF85338.1 - 1.3e-101 338.4 0.0 1.5e-101 338.2 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1961) DUF1080 PF06439.11 EXF85338.1 - 0.034 14.2 0.0 0.039 14.0 0.0 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1080) DSPc PF00782.20 EXF85340.1 - 1.1e-11 44.7 0.0 4.6e-05 23.2 0.0 3.3 3 0 0 3 3 3 3 Dual specificity phosphatase, catalytic domain rRNA_methylase PF06962.12 EXF85340.1 - 0.0045 17.0 0.6 0.0089 16.0 0.6 1.5 1 0 0 1 1 1 1 Putative rRNA methylase zinc_ribbon_4 PF13717.6 EXF85340.1 - 0.35 10.8 1.9 0.86 9.6 0.3 2.4 2 0 0 2 2 2 0 zinc-ribbon domain zf-H2C2_2 PF13465.6 EXF85341.1 - 0.0074 16.7 0.3 0.0074 16.7 0.3 3.5 5 0 0 5 5 5 1 Zinc-finger double domain zf-C2H2 PF00096.26 EXF85341.1 - 0.013 16.0 22.2 0.042 14.3 0.8 5.1 4 0 0 4 4 4 0 Zinc finger, C2H2 type zf-CHCC PF10276.9 EXF85341.1 - 0.11 12.6 2.4 5.8 7.1 0.3 2.5 2 0 0 2 2 2 0 Zinc-finger domain zf-C2H2_4 PF13894.6 EXF85341.1 - 2.2 9.3 23.9 0.19 12.6 1.4 5.2 4 0 0 4 4 4 0 C2H2-type zinc finger Peroxidase_2 PF01328.17 EXF85342.1 - 7.9e-45 153.7 0.5 2.7e-44 152.0 0.5 1.7 1 1 0 1 1 1 1 Peroxidase, family 2 Peptidase_S9 PF00326.21 EXF85343.1 - 3.8e-15 55.9 0.0 4.9e-15 55.6 0.0 1.1 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_3 PF07859.13 EXF85343.1 - 2.4e-06 27.6 0.0 3.1e-06 27.2 0.0 1.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold DLH PF01738.18 EXF85343.1 - 4.6e-05 23.1 0.0 8.4e-05 22.2 0.0 1.5 1 0 0 1 1 1 1 Dienelactone hydrolase family Hydrolase_4 PF12146.8 EXF85343.1 - 0.00054 19.3 0.0 0.17 11.1 0.0 2.2 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EXF85343.1 - 0.0026 17.5 0.0 0.58 9.8 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold FSH1 PF03959.13 EXF85343.1 - 0.027 14.1 0.0 0.07 12.8 0.0 1.5 1 1 0 1 1 1 0 Serine hydrolase (FSH1) Peptidase_S15 PF02129.18 EXF85343.1 - 0.12 12.0 0.0 5.3 6.6 0.0 2.2 1 1 1 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) Say1_Mug180 PF10340.9 EXF85343.1 - 0.13 11.1 0.0 0.21 10.4 0.0 1.2 1 0 0 1 1 1 0 Steryl acetyl hydrolase Ank_4 PF13637.6 EXF85344.1 - 1.9e-18 66.5 4.0 2.9e-06 27.7 0.2 5.1 5 0 0 5 5 5 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EXF85344.1 - 6.2e-17 61.4 11.0 8.9e-07 29.1 0.6 4.7 4 0 0 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EXF85344.1 - 4.4e-14 51.2 4.6 0.0027 18.0 0.1 5.3 4 1 0 4 4 4 4 Ankyrin repeat Ank_2 PF12796.7 EXF85344.1 - 6.6e-14 52.3 7.5 5.8e-07 30.0 1.0 3.5 2 2 0 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 EXF85344.1 - 2.1e-07 31.1 15.6 0.026 14.9 0.0 5.9 6 0 0 6 6 6 3 Ankyrin repeat F-box-like PF12937.7 EXF85344.1 - 0.00011 22.1 0.2 0.00039 20.3 0.2 1.9 1 1 0 1 1 1 1 F-box-like Glyco_hydro_3_C PF01915.22 EXF85345.1 - 1.8e-44 152.1 0.1 2.9e-44 151.5 0.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.6 EXF85345.1 - 7.3e-27 93.3 0.7 4e-25 87.7 0.2 2.4 2 0 0 2 2 2 1 Fibronectin type III-like domain Glyco_hydro_3 PF00933.21 EXF85345.1 - 4.8e-25 88.6 0.3 1.1e-15 57.9 0.1 2.3 2 0 0 2 2 2 2 Glycosyl hydrolase family 3 N terminal domain Vfa1 PF08432.10 EXF85346.1 - 4e-40 138.1 23.4 4.6e-40 137.9 23.4 1.0 1 0 0 1 1 1 1 AAA-ATPase Vps4-associated protein 1 ORC5_C PF14630.6 EXF85346.1 - 0.0012 18.4 0.2 0.0014 18.3 0.2 1.1 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 5 C-terminus RNA_pol_Rpc4 PF05132.14 EXF85346.1 - 0.034 14.6 8.7 0.044 14.2 8.7 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 Rtf2 PF04641.12 EXF85346.1 - 0.04 13.3 19.5 0.052 12.9 19.5 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger Zip PF02535.22 EXF85346.1 - 0.05 12.8 3.8 0.054 12.7 3.8 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter RR_TM4-6 PF06459.12 EXF85346.1 - 0.058 13.2 14.0 0.065 13.0 14.0 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF913 PF06025.12 EXF85346.1 - 0.066 12.2 4.2 0.062 12.3 4.2 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Presenilin PF01080.17 EXF85346.1 - 0.1 11.3 5.8 0.11 11.2 5.8 1.1 1 0 0 1 1 1 0 Presenilin PPL5 PF18168.1 EXF85346.1 - 0.11 11.8 8.1 0.13 11.6 8.1 1.1 1 0 0 1 1 1 0 Prim-pol family 5 CDC45 PF02724.14 EXF85346.1 - 0.11 10.7 11.8 0.11 10.7 11.8 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF4820 PF16091.5 EXF85346.1 - 0.12 11.8 6.7 0.12 11.7 6.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Afi1 PF07792.12 EXF85346.1 - 0.13 12.7 9.1 0.16 12.4 9.1 1.2 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Connexin PF00029.19 EXF85346.1 - 0.17 11.6 9.5 0.13 12.0 7.1 1.8 2 0 0 2 2 2 0 Connexin HCO3_cotransp PF00955.21 EXF85346.1 - 0.28 9.9 0.5 0.32 9.8 0.5 1.1 1 0 0 1 1 1 0 HCO3- transporter family DDHD PF02862.17 EXF85346.1 - 0.34 11.0 3.8 0.38 10.9 3.8 1.1 1 0 0 1 1 1 0 DDHD domain SAPS PF04499.15 EXF85346.1 - 0.38 9.5 7.8 0.38 9.5 7.8 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein CSG2 PF16965.5 EXF85346.1 - 0.44 9.4 1.3 0.4 9.6 1.3 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator RPN2_C PF18004.1 EXF85346.1 - 0.47 10.4 21.5 0.71 9.8 21.5 1.2 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain SpoIIP PF07454.11 EXF85346.1 - 0.47 9.9 12.5 0.56 9.6 12.5 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DUF2722 PF10846.8 EXF85346.1 - 0.55 9.1 10.2 0.59 9.0 10.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) DUF1168 PF06658.12 EXF85346.1 - 0.63 9.9 28.7 0.9 9.4 28.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) CLN3 PF02487.17 EXF85346.1 - 0.78 8.7 4.0 0.85 8.6 4.0 1.1 1 0 0 1 1 1 0 CLN3 protein PTPRCAP PF15713.5 EXF85346.1 - 0.78 10.0 12.3 1 9.6 12.3 1.1 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated DUF4407 PF14362.6 EXF85346.1 - 0.84 8.9 4.2 0.99 8.7 4.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Serinc PF03348.15 EXF85346.1 - 1.7 7.5 3.9 1.7 7.5 3.9 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) NPR3 PF03666.13 EXF85346.1 - 1.7 7.3 12.6 2 7.1 12.6 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 GAGA_bind PF06217.12 EXF85346.1 - 1.9 8.7 10.7 1.9 8.7 10.7 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family Hid1 PF12722.7 EXF85346.1 - 1.9 6.5 6.6 2.2 6.3 6.6 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein VIR_N PF15912.5 EXF85346.1 - 2.3 7.8 9.9 2.7 7.5 9.9 1.1 1 0 0 1 1 1 0 Virilizer, N-terminal RNA_pol_3_Rpc31 PF11705.8 EXF85346.1 - 2.4 8.4 22.6 2.9 8.1 22.6 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 RNA_polI_A34 PF08208.11 EXF85346.1 - 2.5 8.2 30.9 3.1 7.8 30.9 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 Atrophin-1 PF03154.15 EXF85346.1 - 3.4 5.8 20.3 4.2 5.5 20.3 1.1 1 0 0 1 1 1 0 Atrophin-1 family Tom22 PF04281.13 EXF85346.1 - 4 7.2 12.1 4.6 7.0 10.7 1.8 2 0 0 2 2 2 0 Mitochondrial import receptor subunit Tom22 TRAP_alpha PF03896.16 EXF85346.1 - 4.6 6.4 10.5 6.4 5.9 10.5 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit TFB6 PF17110.5 EXF85346.1 - 6.4 6.5 10.0 9 6.0 10.0 1.3 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH MscS_TM PF12794.7 EXF85346.1 - 7.1 5.4 5.8 8.9 5.1 5.8 1.1 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 DNA_pol_phi PF04931.13 EXF85346.1 - 7.2 4.6 21.9 9.3 4.2 21.9 1.0 1 0 0 1 1 1 0 DNA polymerase phi NARP1 PF12569.8 EXF85346.1 - 7.9 5.3 23.3 9.8 5.0 23.3 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 DUF2956 PF11169.8 EXF85346.1 - 8.2 6.7 17.5 15 5.9 17.5 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2956) MCM_bind PF09739.9 EXF85346.1 - 8.5 4.7 12.1 10 4.5 12.1 1.0 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Rtt106 PF08512.12 EXF85347.1 - 7.7e-30 103.2 0.0 1.3e-29 102.4 0.0 1.4 1 0 0 1 1 1 1 Histone chaperone Rttp106-like PH_18 PF18469.1 EXF85347.1 - 0.016 15.2 0.0 0.054 13.5 0.0 1.9 1 1 0 1 1 1 0 Pleckstrin homology domain Cwf_Cwc_15 PF04889.12 EXF85347.1 - 0.22 11.2 22.2 0.34 10.6 22.2 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Paf1 PF03985.13 EXF85347.1 - 4.3 6.2 10.8 6.1 5.7 10.8 1.1 1 0 0 1 1 1 0 Paf1 Amino_oxidase PF01593.24 EXF85348.1 - 3.9e-58 197.8 0.0 4.6e-58 197.6 0.0 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EXF85348.1 - 1.1e-13 51.2 0.2 2.4e-13 50.1 0.2 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 EXF85348.1 - 7.3e-06 25.4 0.0 0.032 13.5 0.1 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EXF85348.1 - 1e-05 25.1 0.1 1.5e-05 24.5 0.1 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EXF85348.1 - 1.1e-05 24.8 0.5 1.8e-05 24.0 0.5 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EXF85348.1 - 1.2e-05 24.7 0.0 2e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EXF85348.1 - 1.3e-05 25.0 0.6 2.7e-05 24.0 0.6 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 EXF85348.1 - 2.3e-05 24.9 0.2 5e-05 23.8 0.2 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EXF85348.1 - 4.9e-05 22.7 0.1 8.4e-05 21.9 0.1 1.3 1 0 0 1 1 1 1 Thi4 family HI0933_like PF03486.14 EXF85348.1 - 0.00015 20.6 0.2 0.00023 20.0 0.2 1.3 1 0 0 1 1 1 1 HI0933-like protein FAD_binding_3 PF01494.19 EXF85348.1 - 0.00024 20.5 0.1 0.00036 19.9 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain GIDA PF01134.22 EXF85348.1 - 0.013 14.6 0.2 0.02 14.0 0.2 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A AlaDh_PNT_C PF01262.21 EXF85348.1 - 0.018 14.4 0.0 0.03 13.6 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain GDI PF00996.18 EXF85348.1 - 0.019 13.5 0.0 0.062 11.8 0.0 1.7 2 0 0 2 2 2 0 GDP dissociation inhibitor GH131_N PF18271.1 EXF85349.1 - 3.7e-77 259.5 0.0 4.2e-77 259.3 0.0 1.0 1 0 0 1 1 1 1 Glycoside hydrolase 131 catalytic N-terminal domain Glyco_hydro_79C PF16862.5 EXF85352.1 - 7.6e-07 30.0 0.1 3.8e-06 27.7 0.0 2.3 3 0 0 3 3 3 1 Glycosyl hydrolase family 79 C-terminal beta domain p450 PF00067.22 EXF85353.1 - 1e-26 93.7 0.0 2.4e-25 89.2 0.0 2.0 2 0 0 2 2 2 2 Cytochrome P450 MCU PF04678.13 EXF85354.1 - 8.9e-23 81.3 0.2 8.9e-23 81.3 0.2 2.2 3 0 0 3 3 3 1 Mitochondrial calcium uniporter Acetyltransf_8 PF13523.6 EXF85355.1 - 1.4e-42 144.9 0.1 2.2e-42 144.2 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain CLN3 PF02487.17 EXF85356.1 - 1.6e-164 547.8 7.0 1.8e-164 547.6 7.0 1.0 1 0 0 1 1 1 1 CLN3 protein DUF1674 PF07896.12 EXF85358.1 - 0.022 15.3 0.2 0.037 14.5 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1674) DUF5336 PF17270.2 EXF85358.1 - 0.071 12.7 0.0 0.071 12.7 0.0 1.4 2 0 0 2 2 2 0 Family of unknown function (DUF5336) GMC_oxred_N PF00732.19 EXF85359.1 - 1.4e-62 211.7 0.2 1.9e-62 211.3 0.2 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EXF85359.1 - 2.6e-29 102.6 0.0 5.5e-29 101.5 0.0 1.6 1 0 0 1 1 1 1 GMC oxidoreductase DAO PF01266.24 EXF85359.1 - 0.00015 21.5 0.3 0.0028 17.3 0.0 2.4 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EXF85359.1 - 0.00017 21.8 0.0 0.00064 19.9 0.0 2.1 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 EXF85359.1 - 0.00018 20.7 0.8 0.00038 19.6 0.1 1.8 2 0 0 2 2 2 1 Lycopene cyclase protein Thi4 PF01946.17 EXF85359.1 - 0.00031 20.1 0.1 0.00062 19.1 0.1 1.4 1 0 0 1 1 1 1 Thi4 family FAD_binding_2 PF00890.24 EXF85359.1 - 0.0047 16.1 1.0 0.021 13.9 0.5 2.0 2 0 0 2 2 2 1 FAD binding domain HI0933_like PF03486.14 EXF85359.1 - 0.015 14.0 0.3 0.12 11.1 0.0 2.0 2 0 0 2 2 2 0 HI0933-like protein Pyr_redox_2 PF07992.14 EXF85359.1 - 0.016 14.5 0.6 0.097 11.9 0.3 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EXF85359.1 - 0.022 14.0 1.4 0.11 11.8 0.3 2.2 2 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EXF85359.1 - 0.054 13.5 0.6 0.21 11.5 0.1 2.1 2 0 0 2 2 2 0 FAD-NAD(P)-binding TrkA_N PF02254.18 EXF85359.1 - 0.11 12.8 0.3 0.56 10.5 0.1 2.4 2 0 0 2 2 2 0 TrkA-N domain Pyr_redox PF00070.27 EXF85359.1 - 0.15 12.7 0.4 1.2 9.8 0.3 2.5 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase ADH_N PF08240.12 EXF85360.1 - 4.5e-07 29.7 0.1 7.5e-06 25.8 0.1 2.2 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EXF85360.1 - 0.0084 16.1 0.0 0.022 14.7 0.0 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ABC2_membrane PF01061.24 EXF85361.1 - 3.6e-81 271.6 65.8 9.6e-42 142.8 18.8 3.8 4 0 0 4 4 4 2 ABC-2 type transporter ABC_tran PF00005.27 EXF85361.1 - 1.7e-37 129.0 0.1 3.7e-17 63.1 0.0 2.8 3 0 0 3 3 2 2 ABC transporter PDR_CDR PF06422.12 EXF85361.1 - 6.2e-37 125.4 4.6 8.1e-30 102.6 0.2 3.1 3 0 0 3 3 2 2 CDR ABC transporter ABC_trans_N PF14510.6 EXF85361.1 - 2.2e-19 69.9 0.0 5.4e-19 68.6 0.0 1.7 1 0 0 1 1 1 1 ABC-transporter N-terminal AAA_25 PF13481.6 EXF85361.1 - 2.2e-07 30.7 0.3 6e-05 22.7 0.0 2.8 3 0 0 3 3 3 1 AAA domain AAA_16 PF13191.6 EXF85361.1 - 1.6e-06 28.6 0.3 0.00043 20.7 0.1 2.7 2 0 0 2 2 2 1 AAA ATPase domain RsgA_GTPase PF03193.16 EXF85361.1 - 1.2e-05 25.3 0.1 0.0053 16.7 0.0 2.6 2 0 0 2 2 2 1 RsgA GTPase AAA_33 PF13671.6 EXF85361.1 - 2.1e-05 24.7 0.1 0.0018 18.5 0.1 2.9 3 0 0 3 3 3 1 AAA domain AAA_18 PF13238.6 EXF85361.1 - 0.00069 20.2 0.0 0.011 16.3 0.0 2.6 3 0 0 3 3 2 1 AAA domain AAA_29 PF13555.6 EXF85361.1 - 0.0011 18.6 2.3 0.052 13.3 0.1 2.7 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_22 PF13401.6 EXF85361.1 - 0.005 17.1 0.7 2 8.7 0.1 2.9 2 0 0 2 2 2 1 AAA domain cobW PF02492.19 EXF85361.1 - 0.0063 16.1 2.0 0.055 13.1 0.1 2.3 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_30 PF13604.6 EXF85361.1 - 0.0077 16.0 0.2 0.97 9.1 0.1 2.4 2 0 0 2 2 2 1 AAA domain SMC_N PF02463.19 EXF85361.1 - 0.013 15.0 0.0 3.7 6.9 0.0 3.2 3 0 0 3 3 3 0 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EXF85361.1 - 0.014 15.2 0.0 1.2 8.9 0.0 2.4 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system MMR_HSR1 PF01926.23 EXF85361.1 - 0.023 14.8 0.1 6.7 6.8 0.0 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase Ploopntkinase3 PF18751.1 EXF85361.1 - 0.1 12.5 0.3 1 9.2 0.0 2.3 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 dNK PF01712.19 EXF85361.1 - 0.14 12.0 0.0 2.5 7.9 0.0 2.2 2 0 0 2 2 2 0 Deoxynucleoside kinase NACHT PF05729.12 EXF85361.1 - 0.15 11.9 2.7 2.4 8.1 0.3 2.6 2 0 0 2 2 2 0 NACHT domain AAA_17 PF13207.6 EXF85361.1 - 0.16 12.4 0.8 1.9 8.9 0.0 2.7 3 0 0 3 3 2 0 AAA domain RNA_helicase PF00910.22 EXF85361.1 - 0.18 12.2 0.1 37 4.8 0.0 2.7 2 0 0 2 2 2 0 RNA helicase MFS_1 PF07690.16 EXF85362.1 - 7.3e-43 146.8 61.6 3.9e-40 137.9 46.6 2.7 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF5345 PF17280.2 EXF85362.1 - 0.34 10.9 4.8 0.42 10.6 2.6 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5345) TRI5 PF06330.11 EXF85363.1 - 4e-09 35.8 0.0 4.9e-09 35.5 0.0 1.1 1 0 0 1 1 1 1 Trichodiene synthase (TRI5) Cyto_heme_lyase PF01265.17 EXF85364.1 - 4.9e-42 144.5 30.0 1.2e-40 139.9 17.2 3.8 1 1 1 2 2 2 2 Cytochrome c/c1 heme lyase S36_mt PF10937.8 EXF85365.1 - 9.6e-40 136.8 1.4 1.3e-39 136.4 1.4 1.2 1 0 0 1 1 1 1 Ribosomal protein S36, mitochondrial DUF647 PF04884.14 EXF85366.1 - 7.5e-94 313.9 3.0 2.5e-93 312.2 1.5 2.0 2 0 0 2 2 2 1 Vitamin B6 photo-protection and homoeostasis MDD_C PF18376.1 EXF85367.1 - 4.1e-63 212.5 0.0 5.8e-63 212.0 0.0 1.2 1 0 0 1 1 1 1 Mevalonate 5-diphosphate decarboxylase C-terminal domain GHMP_kinases_N PF00288.26 EXF85367.1 - 1.1e-08 35.2 2.2 2e-08 34.3 0.6 2.3 2 0 0 2 2 2 1 GHMP kinases N terminal domain Cyclin_N2 PF16500.5 EXF85368.1 - 0.22 12.3 6.4 2.2 9.1 0.2 3.6 3 1 2 5 5 5 0 N-terminal region of cyclin_N Lsm_interact PF05391.11 EXF85368.1 - 3.6 7.2 4.8 1 8.9 1.1 2.1 2 0 0 2 2 2 0 Lsm interaction motif Abhydrolase_1 PF00561.20 EXF85369.1 - 1.4e-05 24.8 0.0 0.00031 20.5 0.0 2.1 1 1 1 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EXF85369.1 - 3.6e-05 24.5 0.8 3.6e-05 24.5 0.8 2.0 1 1 1 2 2 2 1 Alpha/beta hydrolase family DUF1100 PF06500.11 EXF85369.1 - 0.00049 19.0 0.0 0.0009 18.1 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1100) Peptidase_S15 PF02129.18 EXF85369.1 - 0.001 18.8 0.0 0.0044 16.6 0.0 1.9 1 1 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) BAAT_C PF08840.11 EXF85369.1 - 0.002 18.1 0.0 0.0051 16.7 0.0 1.6 1 1 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal DLH PF01738.18 EXF85369.1 - 0.014 14.9 0.1 2.8 7.4 0.0 2.3 1 1 1 2 2 2 0 Dienelactone hydrolase family Hydrolase_4 PF12146.8 EXF85369.1 - 0.029 13.6 0.0 0.11 11.8 0.0 1.8 2 0 0 2 2 2 0 Serine aminopeptidase, S33 AXE1 PF05448.12 EXF85369.1 - 0.039 12.6 0.2 0.21 10.2 0.0 2.2 3 0 0 3 3 3 0 Acetyl xylan esterase (AXE1) SnoaL_4 PF13577.6 EXF85370.1 - 8e-15 55.1 0.0 1.1e-14 54.7 0.0 1.1 1 0 0 1 1 1 1 SnoaL-like domain PHO4 PF01384.20 EXF85371.1 - 2e-112 375.6 17.2 2.4e-112 375.3 17.2 1.1 1 0 0 1 1 1 1 Phosphate transporter family HET PF06985.11 EXF85372.1 - 4.7e-31 108.1 0.0 9.7e-31 107.1 0.0 1.6 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) DUF3112 PF11309.8 EXF85373.1 - 2.2e-09 37.1 0.1 2.2e-09 37.1 0.1 1.9 3 0 0 3 3 3 1 Protein of unknown function (DUF3112) Acetyltransf_10 PF13673.7 EXF85374.1 - 1.2e-06 28.5 0.0 2.4e-06 27.5 0.0 1.5 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EXF85374.1 - 2.7e-06 27.6 0.1 1.1e-05 25.6 0.1 1.9 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EXF85374.1 - 0.00022 21.6 0.0 0.00052 20.4 0.0 1.6 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain OST_IS PF18246.1 EXF85374.1 - 0.026 14.8 0.0 0.052 13.8 0.0 1.4 1 0 0 1 1 1 0 Oligosaccharyltransferase Insert domain Acetyltransf_9 PF13527.7 EXF85374.1 - 0.082 13.0 0.2 0.51 10.4 0.0 2.2 2 2 0 2 2 2 0 Acetyltransferase (GNAT) domain AAA PF00004.29 EXF85375.1 - 1.6e-15 57.7 0.0 3.2e-15 56.7 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rep_fac_C PF08542.11 EXF85375.1 - 5e-14 52.5 0.0 1.3e-13 51.1 0.0 1.8 1 0 0 1 1 1 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.6 EXF85375.1 - 8e-12 45.2 0.0 6.6e-11 42.2 0.0 2.2 1 1 0 1 1 1 1 DNA polymerase III, delta subunit Rad17 PF03215.15 EXF85375.1 - 4.4e-08 33.3 0.0 8.8e-08 32.3 0.0 1.5 1 1 0 1 1 1 1 Rad17 P-loop domain AAA_assoc_2 PF16193.5 EXF85375.1 - 2.6e-07 30.9 0.1 7.5e-07 29.4 0.0 1.9 2 0 0 2 2 1 1 AAA C-terminal domain AAA_30 PF13604.6 EXF85375.1 - 1e-06 28.6 0.0 2.9e-06 27.1 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EXF85375.1 - 9.5e-06 25.9 0.0 5.5e-05 23.5 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EXF85375.1 - 1.2e-05 25.7 0.1 0.00012 22.5 0.0 2.3 2 2 1 3 3 3 1 AAA ATPase domain AAA_11 PF13086.6 EXF85375.1 - 1.4e-05 25.0 0.1 0.0001 22.2 0.0 2.1 1 1 0 2 2 2 1 AAA domain DUF815 PF05673.13 EXF85375.1 - 6.2e-05 22.3 0.0 0.0001 21.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_5 PF07728.14 EXF85375.1 - 0.00012 22.1 0.1 0.00038 20.5 0.1 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 EXF85375.1 - 0.00019 21.2 0.0 0.001 18.8 0.0 2.1 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain DNA_pol3_delta PF06144.13 EXF85375.1 - 0.00027 20.8 0.1 0.0005 19.9 0.1 1.3 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA_3 PF07726.11 EXF85375.1 - 0.0003 20.6 0.1 0.002 18.0 0.1 2.2 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.6 EXF85375.1 - 0.00043 20.6 0.3 0.0014 18.9 0.0 1.9 2 1 0 2 2 1 1 AAA domain AAA_24 PF13479.6 EXF85375.1 - 0.00064 19.5 0.0 0.0013 18.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain Sigma54_activat PF00158.26 EXF85375.1 - 0.00089 19.0 0.0 0.0018 18.0 0.0 1.4 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_14 PF13173.6 EXF85375.1 - 0.0015 18.5 0.0 0.0029 17.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain PhoH PF02562.16 EXF85375.1 - 0.0019 17.7 0.0 0.84 9.1 0.0 2.6 2 0 0 2 2 2 1 PhoH-like protein Mg_chelatase PF01078.21 EXF85375.1 - 0.0019 17.6 0.0 0.0081 15.6 0.0 2.0 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 EXF85375.1 - 0.0051 17.1 0.0 0.0099 16.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain TniB PF05621.11 EXF85375.1 - 0.0082 15.6 0.0 0.053 12.9 0.0 2.1 2 0 0 2 2 2 1 Bacterial TniB protein ResIII PF04851.15 EXF85375.1 - 0.01 15.9 0.0 0.043 13.8 0.0 2.0 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_7 PF12775.7 EXF85375.1 - 0.013 15.0 0.0 0.028 13.9 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_18 PF13238.6 EXF85375.1 - 0.014 15.9 0.0 0.025 15.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 EXF85375.1 - 0.02 14.8 0.0 0.26 11.1 0.0 2.1 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea RNA_helicase PF00910.22 EXF85375.1 - 0.064 13.7 0.0 0.17 12.3 0.0 1.8 1 1 0 1 1 1 0 RNA helicase AAA_25 PF13481.6 EXF85375.1 - 0.065 12.8 0.0 0.16 11.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.9 EXF85375.1 - 0.071 12.3 0.0 0.12 11.6 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) DEAD PF00270.29 EXF85375.1 - 0.095 12.5 0.0 0.62 9.8 0.0 2.1 1 1 1 2 2 2 0 DEAD/DEAH box helicase Fringe PF02434.16 EXF85376.1 - 1.1e-05 25.1 1.9 0.00012 21.6 1.8 2.2 1 1 0 1 1 1 1 Fringe-like Galactosyl_T PF01762.21 EXF85376.1 - 0.027 14.3 0.1 0.099 12.5 0.1 1.8 1 1 1 2 2 2 0 Galactosyltransferase PAN_4 PF14295.6 EXF85376.1 - 0.036 14.0 0.7 0.036 14.0 0.7 2.2 2 0 0 2 2 2 0 PAN domain CAP_N PF01213.19 EXF85376.1 - 3.5 7.0 8.6 6.2 6.2 8.6 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal 2OG-FeII_Oxy_3 PF13640.6 EXF85377.1 - 4.5e-10 40.3 0.1 7.2e-10 39.6 0.1 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Peptidase_M24 PF00557.24 EXF85378.1 - 1.3e-41 142.7 0.0 1.5e-40 139.2 0.0 2.1 1 1 0 1 1 1 1 Metallopeptidase family M24 Creatinase_N PF01321.18 EXF85378.1 - 0.005 17.5 0.0 0.013 16.2 0.0 1.8 1 0 0 1 1 1 1 Creatinase/Prolidase N-terminal domain Sugar_tr PF00083.24 EXF85379.1 - 2.1e-32 112.6 30.2 2.6e-16 59.6 11.4 2.0 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 EXF85379.1 - 4e-25 88.5 42.7 1.2e-14 54.1 10.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EXF85379.1 - 0.00026 19.7 27.4 0.071 11.7 8.9 2.5 1 1 1 2 2 2 2 MFS/sugar transport protein Peptidase_S8 PF00082.22 EXF85380.1 - 9.8e-29 100.5 4.8 1.6e-28 99.9 4.8 1.2 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 EXF85380.1 - 4.5e-10 40.1 0.0 9.2e-10 39.1 0.0 1.5 1 0 0 1 1 1 1 Peptidase inhibitor I9 OPT PF03169.15 EXF85381.1 - 7.8e-125 417.9 38.4 9e-125 417.7 38.4 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Phage_holin_5_2 PF16079.5 EXF85381.1 - 0.012 16.0 0.7 0.012 16.0 0.7 3.8 4 0 0 4 4 4 0 Phage holin family Hol44, in holin superfamily V CrgA PF06781.12 EXF85381.1 - 0.12 12.4 4.8 0.43 10.7 0.3 3.0 3 0 0 3 3 3 0 Cell division protein CrgA DUF3093 PF11292.8 EXF85381.1 - 1.3 9.3 6.6 3.8 7.8 6.6 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3093) Mannosyl_trans3 PF11051.8 EXF85382.1 - 2.1e-34 119.2 0.0 5.8e-34 117.7 0.0 1.7 1 1 0 1 1 1 1 Mannosyltransferase putative Fungal_trans_2 PF11951.8 EXF85384.1 - 0.0032 16.3 0.4 0.0063 15.4 0.1 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain Arg_decarb_HB PF17810.1 EXF85384.1 - 0.053 13.8 0.1 0.1 12.9 0.1 1.5 1 0 0 1 1 1 0 Arginine decarboxylase helical bundle domain ketoacyl-synt PF00109.26 EXF85385.1 - 1.5e-74 250.8 0.0 3e-74 249.8 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.10 EXF85385.1 - 3.3e-61 206.3 2.1 1e-60 204.7 0.3 2.7 3 0 0 3 3 3 1 KR domain Acyl_transf_1 PF00698.21 EXF85385.1 - 3.4e-56 191.1 0.1 5.8e-56 190.3 0.1 1.3 1 0 0 1 1 1 1 Acyl transferase domain PS-DH PF14765.6 EXF85385.1 - 2.3e-47 161.7 0.0 3.9e-47 160.9 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase Ketoacyl-synt_C PF02801.22 EXF85385.1 - 4.4e-43 146.0 0.3 2.1e-41 140.7 0.0 3.1 3 0 0 3 3 3 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 EXF85385.1 - 1.3e-19 70.7 0.7 3.6e-19 69.3 0.1 2.2 2 0 0 2 2 2 1 Ketoacyl-synthetase C-terminal extension adh_short PF00106.25 EXF85385.1 - 1.1e-15 57.7 0.9 1.7e-14 53.7 0.1 2.6 2 0 0 2 2 2 1 short chain dehydrogenase ADH_zinc_N PF00107.26 EXF85385.1 - 1.2e-11 44.6 0.1 1e-10 41.7 0.0 2.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EXF85385.1 - 1.8e-10 42.0 0.0 6.8e-10 40.1 0.0 2.1 1 0 0 1 1 1 1 Zinc-binding dehydrogenase adh_short_C2 PF13561.6 EXF85385.1 - 5.5e-10 39.2 1.5 1.1e-09 38.3 0.4 2.1 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase ADH_N PF08240.12 EXF85385.1 - 4.8e-07 29.6 0.0 1.3e-06 28.2 0.0 1.8 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain PP-binding PF00550.25 EXF85385.1 - 1.6e-05 25.2 0.3 3.4e-05 24.1 0.3 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site Thiolase_N PF00108.23 EXF85385.1 - 0.035 13.5 0.2 0.076 12.4 0.2 1.5 1 0 0 1 1 1 0 Thiolase, N-terminal domain Polysacc_synt_2 PF02719.15 EXF85385.1 - 0.046 12.9 0.0 0.084 12.0 0.0 1.4 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Formin_GBD_N PF18382.1 EXF85386.1 - 0.098 13.1 0.1 0.16 12.5 0.1 1.3 1 0 0 1 1 1 0 Formin N-terminal GTPase-binding domain FSH1 PF03959.13 EXF85387.1 - 1.5e-31 109.7 0.0 4.8e-31 108.1 0.0 1.7 1 1 0 1 1 1 1 Serine hydrolase (FSH1) ABC_membrane PF00664.23 EXF85388.1 - 2.9e-80 269.8 45.1 7.6e-47 160.2 13.3 2.4 2 1 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EXF85388.1 - 8.8e-63 210.9 0.0 1.6e-32 112.8 0.0 2.4 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EXF85388.1 - 5e-17 62.1 1.8 0.00037 20.0 0.0 4.2 3 1 1 4 4 4 4 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EXF85388.1 - 8.9e-09 35.0 1.0 0.0025 17.5 0.2 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.6 EXF85388.1 - 2.7e-08 34.2 1.1 0.011 16.1 0.0 3.8 2 2 0 2 2 2 2 AAA domain ABC_ATPase PF09818.9 EXF85388.1 - 1.1e-07 31.1 1.9 0.011 14.5 0.2 3.9 4 0 0 4 4 4 2 Predicted ATPase of the ABC class AAA_23 PF13476.6 EXF85388.1 - 2.2e-07 31.6 0.4 0.021 15.3 0.2 2.3 2 0 0 2 2 2 2 AAA domain AAA_30 PF13604.6 EXF85388.1 - 7.1e-07 29.1 0.6 0.023 14.4 0.1 3.4 3 1 0 3 3 3 2 AAA domain AAA_16 PF13191.6 EXF85388.1 - 1.3e-06 28.9 1.7 0.089 13.2 0.0 3.3 2 1 0 2 2 2 2 AAA ATPase domain AAA_21 PF13304.6 EXF85388.1 - 1.3e-06 28.4 1.4 0.022 14.6 0.3 3.1 2 1 1 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 EXF85388.1 - 1.6e-05 24.9 0.0 0.14 12.1 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_25 PF13481.6 EXF85388.1 - 3.1e-05 23.7 0.3 0.33 10.5 0.0 2.9 3 0 0 3 3 3 2 AAA domain AAA_15 PF13175.6 EXF85388.1 - 0.0001 22.2 0.1 0.16 11.6 0.0 2.2 2 0 0 2 2 2 2 AAA ATPase domain AAA_18 PF13238.6 EXF85388.1 - 0.00017 22.2 0.0 0.86 10.2 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_24 PF13479.6 EXF85388.1 - 0.00086 19.1 0.1 0.97 9.1 0.0 2.5 2 0 0 2 2 2 2 AAA domain ATP_bind_1 PF03029.17 EXF85388.1 - 0.0014 18.5 0.1 2 8.1 0.0 2.4 2 0 0 2 2 2 2 Conserved hypothetical ATP binding protein Rad17 PF03215.15 EXF85388.1 - 0.0016 18.4 0.0 2 8.3 0.0 2.4 2 0 0 2 2 2 2 Rad17 P-loop domain AAA PF00004.29 EXF85388.1 - 0.0018 18.7 3.3 29 5.1 0.0 4.4 4 0 0 4 4 4 0 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EXF85388.1 - 0.0023 17.9 0.0 2.7 8.0 0.0 2.9 3 0 0 3 3 2 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 EXF85388.1 - 0.0031 17.7 0.2 4.4 7.5 0.0 2.6 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 EXF85388.1 - 0.0041 16.4 0.1 4.7 6.3 0.0 3.1 3 0 0 3 3 3 0 NB-ARC domain SbcCD_C PF13558.6 EXF85388.1 - 0.0049 17.1 2.4 3.3 8.0 0.3 3.9 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit SRP54 PF00448.22 EXF85388.1 - 0.0086 15.7 1.0 2.8 7.5 0.0 2.9 3 0 0 3 3 3 1 SRP54-type protein, GTPase domain AAA_28 PF13521.6 EXF85388.1 - 0.013 15.8 0.3 2.9 8.1 0.1 2.5 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 EXF85388.1 - 0.013 15.3 0.2 6.2 6.5 0.0 3.8 4 0 0 4 4 4 0 IstB-like ATP binding protein Cytidylate_kin PF02224.18 EXF85388.1 - 0.014 15.1 0.0 4.3 7.0 0.0 2.5 2 0 0 2 2 2 0 Cytidylate kinase ATPase PF06745.13 EXF85388.1 - 0.017 14.5 1.0 0.87 8.9 0.1 2.6 3 0 0 3 3 2 0 KaiC DUF87 PF01935.17 EXF85388.1 - 0.022 14.9 0.5 2.6 8.1 0.0 2.4 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_7 PF12775.7 EXF85388.1 - 0.023 14.2 0.0 4.2 6.8 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_19 PF13245.6 EXF85388.1 - 0.049 14.0 0.9 20 5.5 0.0 3.3 4 0 0 4 4 2 0 AAA domain TniB PF05621.11 EXF85388.1 - 0.054 12.9 0.0 10 5.5 0.0 3.1 3 0 0 3 3 3 0 Bacterial TniB protein NACHT PF05729.12 EXF85388.1 - 0.067 13.1 0.4 6 6.8 0.0 2.5 2 0 0 2 2 2 0 NACHT domain ATP-synt_ab PF00006.25 EXF85388.1 - 0.083 12.5 0.0 12 5.5 0.0 2.5 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_17 PF13207.6 EXF85388.1 - 0.083 13.3 0.0 11 6.4 0.0 2.8 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.6 EXF85388.1 - 0.093 12.8 0.1 23 5.0 0.0 3.3 3 0 0 3 3 3 0 AAA domain APS_kinase PF01583.20 EXF85388.1 - 0.098 12.5 0.1 16 5.3 0.0 2.4 2 0 0 2 2 2 0 Adenylylsulphate kinase cobW PF02492.19 EXF85388.1 - 0.13 11.9 0.3 12 5.5 0.1 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain dNK PF01712.19 EXF85388.1 - 0.15 11.9 0.1 14 5.5 0.0 2.4 2 0 0 2 2 2 0 Deoxynucleoside kinase PRK PF00485.18 EXF85388.1 - 0.16 11.7 0.1 12 5.6 0.0 2.3 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family AAA_11 PF13086.6 EXF85388.1 - 0.18 11.6 0.0 11 5.7 0.0 2.9 3 0 0 3 3 3 0 AAA domain MMR_HSR1 PF01926.23 EXF85388.1 - 0.32 11.1 1.2 29 4.8 0.0 2.9 3 0 0 3 3 3 0 50S ribosome-binding GTPase Cyt-b5 PF00173.28 EXF85389.1 - 9e-15 54.6 0.0 2.1e-14 53.4 0.0 1.7 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain IDO PF01231.18 EXF85389.1 - 6e-12 45.1 0.0 3.3e-11 42.6 0.0 1.9 2 0 0 2 2 2 1 Indoleamine 2,3-dioxygenase FAD_binding_1 PF00667.20 EXF85389.1 - 1.9e-10 40.7 0.0 2.9e-09 36.8 0.0 2.4 2 1 0 2 2 2 1 FAD binding domain NAD_binding_1 PF00175.21 EXF85389.1 - 6.7e-09 36.4 0.0 1.7e-08 35.0 0.0 1.8 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Astro_capsid_p PF12226.8 EXF85389.1 - 0.19 10.8 0.2 0.31 10.2 0.2 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Aldedh PF00171.22 EXF85391.1 - 7.6e-158 525.8 0.1 9.4e-158 525.5 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family NCD1 PF04904.13 EXF85391.1 - 0.056 13.4 0.0 0.15 12.1 0.0 1.7 1 0 0 1 1 1 0 NAB conserved region 1 (NCD1) Mersacidin PF16934.5 EXF85391.1 - 6.6 6.6 8.3 0.92 9.3 0.3 2.5 2 0 0 2 2 2 0 Two-component Enterococcus faecalis cytolysin (EFC) GMC_oxred_N PF00732.19 EXF85392.1 - 2.5e-54 184.7 0.0 3.1e-54 184.4 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EXF85392.1 - 4e-36 124.7 0.0 6.2e-36 124.1 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.24 EXF85392.1 - 5.3e-07 29.1 0.1 0.0064 15.6 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain Lycopene_cycl PF05834.12 EXF85392.1 - 1.2e-05 24.5 0.0 1.8e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein NAD_binding_8 PF13450.6 EXF85392.1 - 4.4e-05 23.6 0.1 0.00048 20.3 0.1 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EXF85392.1 - 5.9e-05 22.5 0.0 0.0071 15.6 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EXF85392.1 - 0.00051 19.7 0.3 0.0027 17.3 0.1 2.2 3 0 0 3 3 3 1 FAD dependent oxidoreductase Trp_halogenase PF04820.14 EXF85392.1 - 0.018 13.9 0.0 0.027 13.3 0.0 1.2 1 0 0 1 1 1 0 Tryptophan halogenase Pyr_redox PF00070.27 EXF85392.1 - 0.092 13.3 0.1 1.6 9.3 0.0 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EXF85392.1 - 0.12 11.6 0.0 0.26 10.5 0.0 1.5 1 0 0 1 1 1 0 Thi4 family HI0933_like PF03486.14 EXF85392.1 - 0.22 10.2 0.1 0.76 8.4 0.0 1.7 2 0 0 2 2 2 0 HI0933-like protein Pectinesterase PF01095.19 EXF85393.1 - 6.3e-40 136.7 9.1 1.1e-39 136.0 9.1 1.3 1 0 0 1 1 1 1 Pectinesterase Pec_lyase_C PF00544.19 EXF85393.1 - 1.4e-20 73.8 11.8 1.4e-19 70.5 11.8 2.5 1 1 0 1 1 1 1 Pectate lyase Beta_helix PF13229.6 EXF85393.1 - 0.00033 20.5 30.7 0.0082 16.0 10.2 4.0 2 2 1 4 4 4 2 Right handed beta helix region MFS_1 PF07690.16 EXF85394.1 - 1.5e-18 66.9 40.5 1.3e-10 40.7 23.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily HNH_2 PF13391.6 EXF85395.1 - 2.7e-06 27.4 0.2 5.4e-06 26.5 0.2 1.5 1 0 0 1 1 1 1 HNH endonuclease SPX PF03105.19 EXF85396.1 - 1.3e-10 41.7 15.7 8.8e-06 25.9 0.0 4.0 2 1 2 4 4 4 3 SPX domain DUF998 PF06197.13 EXF85396.1 - 0.0045 16.6 2.1 0.0072 15.9 2.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF998) Chromate_transp PF02417.15 EXF85396.1 - 0.01 16.0 0.1 0.015 15.5 0.1 1.2 1 0 0 1 1 1 0 Chromate transporter Fungal_trans PF04082.18 EXF85397.1 - 3.4e-09 36.1 0.6 7.6e-09 35.0 0.1 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF85397.1 - 2.3e-05 24.4 15.4 2.3e-05 24.4 15.4 2.4 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Acetyltransf_1 PF00583.25 EXF85399.1 - 2.3e-06 27.8 0.0 3.2e-06 27.4 0.0 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EXF85399.1 - 1.8e-05 25.1 0.0 3.4e-05 24.2 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EXF85399.1 - 0.00073 19.5 0.0 0.0012 18.7 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EXF85399.1 - 0.0014 18.7 0.0 0.016 15.2 0.0 2.1 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EXF85399.1 - 0.13 12.3 0.0 0.33 10.9 0.0 1.7 1 1 0 1 1 1 0 FR47-like protein Glyco_transf_28 PF03033.20 EXF85402.1 - 2.1e-08 34.3 0.0 4e-08 33.4 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain UDPGT PF00201.18 EXF85402.1 - 0.0003 19.7 0.0 0.00081 18.3 0.0 1.6 2 0 0 2 2 2 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 EXF85402.1 - 0.021 14.8 0.0 0.044 13.8 0.0 1.5 1 0 0 1 1 1 0 Glycosyltransferase family 28 C-terminal domain Formyl_trans_N PF00551.19 EXF85404.1 - 8.1e-25 87.6 0.0 1.1e-24 87.2 0.0 1.2 1 0 0 1 1 1 1 Formyl transferase MEDS PF14417.6 EXF85406.1 - 0.076 12.8 0.3 4.1 7.2 0.0 2.6 1 1 1 2 2 2 0 MEDS: MEthanogen/methylotroph, DcmR Sensory domain DUF1366 PF07104.11 EXF85406.1 - 1.4 8.6 12.8 0.066 12.9 2.1 2.6 1 1 0 2 2 2 0 Protein of unknown function (DUF1366) Baculo_IE-1 PF05290.11 EXF85406.1 - 1.4 8.8 9.3 4.5 7.2 0.6 2.9 1 1 2 3 3 3 0 Baculovirus immediate-early protein (IE-0) Synaptobrevin PF00957.21 EXF85406.1 - 2.1 8.2 8.8 0.33 10.8 2.8 2.5 1 1 0 2 2 2 0 Synaptobrevin DUF4446 PF14584.6 EXF85406.1 - 6.7 6.7 14.9 7.1 6.6 2.9 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF4446) FAD_binding_8 PF08022.12 EXF85407.1 - 1.8e-18 66.6 0.0 3.5e-18 65.7 0.0 1.5 1 0 0 1 1 1 1 FAD-binding domain Ferric_reduct PF01794.19 EXF85407.1 - 8e-13 48.6 4.9 1.7e-12 47.5 4.9 1.6 1 0 0 1 1 1 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 EXF85407.1 - 9.7e-09 35.5 0.0 1.2e-05 25.5 0.0 2.8 2 1 0 2 2 2 2 Ferric reductase NAD binding domain EF-hand_7 PF13499.6 EXF85407.1 - 0.0034 17.8 0.0 0.0078 16.6 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 EXF85407.1 - 0.026 14.1 0.2 0.053 13.1 0.2 1.5 1 0 0 1 1 1 0 EF hand EF-hand_6 PF13405.6 EXF85407.1 - 0.035 14.0 0.2 0.096 12.7 0.2 1.7 1 0 0 1 1 1 0 EF-hand domain EF-hand_8 PF13833.6 EXF85407.1 - 0.044 13.6 0.2 0.094 12.6 0.2 1.5 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_5 PF13202.6 EXF85407.1 - 0.14 11.7 0.1 0.28 10.7 0.1 1.5 1 0 0 1 1 1 0 EF hand Transthyretin PF00576.21 EXF85408.1 - 5.8e-36 123.5 0.1 1.3e-35 122.4 0.1 1.5 1 1 0 1 1 1 1 HIUase/Transthyretin family DUF3507 PF12015.8 EXF85408.1 - 0.16 11.7 0.0 0.22 11.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3507) Vps62 PF06101.11 EXF85412.1 - 2.2e-11 42.8 0.5 4.5e-11 41.7 0.5 1.4 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 62 TFIIIC_sub6 PF10419.9 EXF85413.1 - 4.5e-27 93.8 0.0 7.4e-27 93.1 0.0 1.4 1 0 0 1 1 1 1 TFIIIC subunit triple barrel domain His_biosynth PF00977.21 EXF85414.1 - 2.8e-48 164.4 0.5 1e-47 162.5 0.5 1.9 1 1 0 1 1 1 1 Histidine biosynthesis protein GATase PF00117.28 EXF85414.1 - 4.9e-17 62.3 0.0 7.9e-17 61.6 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I SNO PF01174.19 EXF85414.1 - 2.8e-08 33.8 0.0 1.5e-07 31.5 0.0 2.0 1 1 0 1 1 1 1 SNO glutamine amidotransferase family GATase_3 PF07685.14 EXF85414.1 - 7.4e-06 25.7 0.0 1.8e-05 24.4 0.0 1.7 1 1 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain Dus PF01207.17 EXF85414.1 - 0.016 14.3 0.0 0.036 13.2 0.0 1.5 1 0 0 1 1 1 0 Dihydrouridine synthase (Dus) Peptidase_C26 PF07722.13 EXF85414.1 - 0.085 12.6 0.1 0.47 10.2 0.0 2.0 2 0 0 2 2 2 0 Peptidase C26 ODC_AZ PF02100.17 EXF85415.1 - 3.5e-44 149.4 0.3 4.9e-44 149.0 0.3 1.2 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme Yippee-Mis18 PF03226.14 EXF85416.1 - 8e-18 64.6 0.3 1.8e-17 63.5 0.3 1.6 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Eapp_C PF10238.9 EXF85416.1 - 0.096 12.8 1.3 0.43 10.6 1.2 2.1 1 1 1 2 2 2 0 E2F-associated phosphoprotein PRCC PF10253.9 EXF85416.1 - 0.15 12.8 13.7 0.56 11.0 13.6 2.0 1 1 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting BIR PF00653.21 EXF85416.1 - 0.22 12.2 0.9 19 6.0 0.1 2.4 2 0 0 2 2 2 0 Inhibitor of Apoptosis domain Mito_fiss_reg PF05308.11 EXF85416.1 - 4.4 7.3 13.1 9.1 6.3 13.1 1.5 1 0 0 1 1 1 0 Mitochondrial fission regulator Nop14 PF04147.12 EXF85416.1 - 9.3 4.3 12.2 15 3.6 12.2 1.3 1 0 0 1 1 1 0 Nop14-like family Peptidase_M20 PF01546.28 EXF85417.1 - 1.4e-33 116.4 0.0 2.7e-33 115.4 0.0 1.5 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EXF85417.1 - 2.9e-13 49.7 0.0 4.7e-13 49.0 0.0 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain DWNN PF08783.11 EXF85418.1 - 6.5e-31 106.5 0.0 1.2e-30 105.6 0.0 1.4 1 0 0 1 1 1 1 DWNN domain zf-CCHC_2 PF13696.6 EXF85418.1 - 1.9e-08 34.0 5.5 1.9e-08 34.0 5.5 1.6 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC PF00098.23 EXF85418.1 - 0.0013 18.7 0.9 0.0013 18.7 0.9 1.8 2 0 0 2 2 2 1 Zinc knuckle zf-C3HC4_2 PF13923.6 EXF85418.1 - 0.0019 18.0 10.3 0.0019 18.0 10.3 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-Nse PF11789.8 EXF85418.1 - 0.03 14.2 6.2 0.076 12.8 6.2 1.6 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit DUF3332 PF11810.8 EXF85418.1 - 0.034 13.8 2.1 0.071 12.7 2.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3332) zf-RING_2 PF13639.6 EXF85418.1 - 0.056 13.8 7.4 0.12 12.7 7.4 1.6 1 0 0 1 1 1 0 Ring finger domain U-box PF04564.15 EXF85418.1 - 0.07 13.3 0.2 0.26 11.5 0.0 2.1 2 0 0 2 2 2 0 U-box domain zf-RING_4 PF14570.6 EXF85418.1 - 0.33 10.8 5.9 0.72 9.7 5.9 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_UBOX PF13445.6 EXF85418.1 - 0.86 9.7 7.1 1.8 8.6 7.1 1.6 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_4 PF15227.6 EXF85418.1 - 0.98 9.6 10.4 2.5 8.3 10.4 1.8 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING FYVE_2 PF02318.16 EXF85418.1 - 1.1 9.5 5.5 0.17 12.1 1.0 2.0 3 0 0 3 3 2 0 FYVE-type zinc finger zf-C3HC4 PF00097.25 EXF85418.1 - 1.2 9.1 10.7 2.3 8.1 10.7 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EXF85418.1 - 9.1 6.3 13.7 0.87 9.6 8.2 2.1 2 1 0 2 2 2 0 zinc-RING finger domain ArsA_ATPase PF02374.15 EXF85419.1 - 7.5e-114 380.0 0.2 8.6e-114 379.8 0.2 1.0 1 0 0 1 1 1 1 Anion-transporting ATPase AAA_31 PF13614.6 EXF85419.1 - 2.2e-15 57.0 0.1 4.5e-14 52.8 0.0 2.4 2 1 0 2 2 2 1 AAA domain CbiA PF01656.23 EXF85419.1 - 3.2e-13 49.8 0.0 4.9e-13 49.2 0.0 1.5 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain ParA PF10609.9 EXF85419.1 - 6.8e-07 29.0 3.1 6.6e-05 22.5 1.0 2.6 2 1 0 2 2 2 2 NUBPL iron-transfer P-loop NTPase Fer4_NifH PF00142.18 EXF85419.1 - 1.6e-06 27.8 0.0 2.7e-06 27.0 0.0 1.5 1 0 0 1 1 1 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family SRP54 PF00448.22 EXF85419.1 - 2.3e-06 27.4 0.2 0.00032 20.4 0.0 3.0 3 0 0 3 3 3 1 SRP54-type protein, GTPase domain CBP_BcsQ PF06564.12 EXF85419.1 - 3.1e-05 23.6 0.0 8.1e-05 22.2 0.0 1.6 2 0 0 2 2 2 1 Cellulose biosynthesis protein BcsQ ATPase PF06745.13 EXF85419.1 - 0.042 13.2 0.5 0.23 10.8 0.0 2.0 2 1 0 2 2 2 0 KaiC PhoH PF02562.16 EXF85419.1 - 0.044 13.2 0.0 0.11 11.9 0.0 1.7 1 0 0 1 1 1 0 PhoH-like protein AAA_25 PF13481.6 EXF85419.1 - 0.061 12.9 0.4 0.14 11.7 0.4 1.7 1 1 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 EXF85419.1 - 0.085 12.1 0.0 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin NB-ARC PF00931.22 EXF85419.1 - 0.095 11.9 0.0 0.2 10.8 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain AAA_18 PF13238.6 EXF85419.1 - 0.095 13.3 0.0 0.24 11.9 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EXF85419.1 - 0.11 12.9 0.0 0.18 12.2 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain IstB_IS21 PF01695.17 EXF85419.1 - 0.12 12.1 0.0 0.22 11.3 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_24 PF13479.6 EXF85419.1 - 0.13 11.9 0.1 0.9 9.2 0.0 2.3 2 1 0 2 2 2 0 AAA domain MipZ PF09140.11 EXF85419.1 - 0.19 11.0 0.1 0.37 10.0 0.1 1.5 1 1 0 1 1 1 0 ATPase MipZ SUR7 PF06687.12 EXF85421.1 - 4.4e-23 82.0 7.5 6.6e-23 81.5 7.5 1.3 1 0 0 1 1 1 1 SUR7/PalI family EphA2_TM PF14575.6 EXF85421.1 - 0.025 15.4 4.0 0.32 11.9 0.0 3.1 3 0 0 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain Claudin_2 PF13903.6 EXF85421.1 - 0.031 14.0 9.9 0.077 12.7 3.1 2.8 1 1 2 3 3 3 0 PMP-22/EMP/MP20/Claudin tight junction WBP-1 PF11669.8 EXF85421.1 - 0.044 14.4 0.0 0.11 13.2 0.0 1.6 1 0 0 1 1 1 0 WW domain-binding protein 1 PAG PF15347.6 EXF85421.1 - 0.2 10.6 0.0 0.29 10.1 0.0 1.2 1 0 0 1 1 1 0 Phosphoprotein associated with glycosphingolipid-enriched Herpes_gE PF02480.16 EXF85421.1 - 0.68 8.6 3.5 0.74 8.5 0.2 2.0 1 1 1 2 2 2 0 Alphaherpesvirus glycoprotein E LapA_dom PF06305.11 EXF85421.1 - 1.1 9.2 0.0 1.1 9.2 0.0 2.6 2 1 0 2 2 2 0 Lipopolysaccharide assembly protein A domain DUF1772 PF08592.11 EXF85421.1 - 9.4 6.5 11.2 2.2 8.6 7.1 2.0 2 1 0 2 2 2 0 Domain of unknown function (DUF1772) Ldi PF18566.1 EXF85422.1 - 3.4e-133 444.1 0.0 4.1e-133 443.8 0.0 1.1 1 0 0 1 1 1 1 Linalool dehydratase/isomerase HepII_C PF18675.1 EXF85422.1 - 0.0041 17.2 0.0 0.011 15.8 0.0 1.7 2 0 0 2 2 2 1 Heparinase II C-terminal domain MRC1 PF09444.10 EXF85423.1 - 3.1e-42 144.5 22.4 3.1e-42 144.5 22.4 8.9 7 3 2 9 9 9 1 MRC1-like domain CorA PF01544.18 EXF85424.1 - 0.055 12.8 0.0 0.11 11.8 0.0 1.4 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Ribosomal_S14 PF00253.21 EXF85424.1 - 0.32 10.8 1.5 0.55 10.0 0.1 2.1 2 0 0 2 2 2 0 Ribosomal protein S14p/S29e PI-PLC-C1 PF16670.5 EXF85425.1 - 0.14 11.2 0.4 5.6 5.9 0.0 2.7 2 1 1 3 3 3 0 Phosphoinositide phospholipase C, Ca2+-dependent PI-PLC-X PF00388.19 EXF85425.1 - 0.16 11.5 0.0 0.24 11.0 0.0 1.2 1 0 0 1 1 1 0 Phosphatidylinositol-specific phospholipase C, X domain Egh16-like PF11327.8 EXF85426.1 - 5.5e-67 225.7 12.9 1.8e-66 224.0 12.9 1.7 1 1 0 1 1 1 1 Egh16-like virulence factor NAD_binding_5 PF07994.12 EXF85427.1 - 6.3e-144 479.3 0.0 8e-144 478.9 0.0 1.1 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase Inos-1-P_synth PF01658.17 EXF85427.1 - 1.7e-45 153.8 0.6 3.7e-45 152.6 0.6 1.6 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase CDH-cyt PF16010.5 EXF85428.1 - 2.3e-21 76.3 0.2 4.3e-21 75.4 0.2 1.4 1 0 0 1 1 1 1 Cytochrome domain of cellobiose dehydrogenase Cytochrom_B561 PF03188.16 EXF85428.1 - 4.4e-09 36.6 10.1 9.6e-09 35.5 10.1 1.5 1 0 0 1 1 1 1 Eukaryotic cytochrome b561 DUF2427 PF10348.9 EXF85428.1 - 7.4e-05 22.5 1.0 7.4e-05 22.5 1.0 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF2427) DOMON PF03351.17 EXF85428.1 - 0.0017 18.5 0.6 0.019 15.2 0.2 2.4 1 1 1 2 2 2 1 DOMON domain Phage_holin_5_2 PF16079.5 EXF85428.1 - 0.062 13.6 0.7 0.17 12.2 0.7 1.8 1 0 0 1 1 1 0 Phage holin family Hol44, in holin superfamily V Pox_P21 PF05313.12 EXF85428.1 - 0.062 12.9 0.2 0.41 10.2 0.0 2.0 2 0 0 2 2 2 0 Poxvirus P21 membrane protein DUF4079 PF13301.6 EXF85428.1 - 0.13 12.5 10.5 0.69 10.1 7.6 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF4079) DUF2207 PF09972.9 EXF85428.1 - 0.18 10.5 7.3 27 3.4 7.3 2.2 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF3309 PF11752.8 EXF85428.1 - 0.55 10.3 5.3 0.94 9.6 3.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3309) DUF4231 PF14015.6 EXF85428.1 - 1.1 9.7 7.2 0.33 11.5 0.8 2.4 1 1 2 3 3 3 0 Protein of unknown function (DUF4231) DUF2306 PF10067.9 EXF85428.1 - 1.8 8.8 8.9 1.1 9.5 2.5 2.5 1 1 1 2 2 2 0 Predicted membrane protein (DUF2306) DUF2157 PF09925.9 EXF85428.1 - 3.4 7.4 14.0 19 5.0 14.0 2.0 1 1 1 2 2 2 0 Predicted membrane protein (DUF2157) RseC_MucC PF04246.12 EXF85428.1 - 8 6.4 9.5 0.31 11.0 2.3 2.4 2 1 1 3 3 3 0 Positive regulator of sigma(E), RseC/MucC MFS_1 PF07690.16 EXF85429.1 - 7.7e-28 97.4 26.9 7.7e-28 97.4 26.9 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF85429.1 - 0.0021 17.0 7.7 0.0085 15.0 7.7 2.0 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1_like PF12832.7 EXF85429.1 - 0.86 8.4 10.6 0.2 10.5 2.4 2.8 2 1 1 3 3 3 0 MFS_1 like family MFS_3 PF05977.13 EXF85429.1 - 5.2 5.4 9.1 0.18 10.1 1.7 2.0 2 1 0 2 2 2 0 Transmembrane secretion effector VSP PF03302.13 EXF85430.1 - 0.0016 17.4 0.2 0.0022 16.9 0.2 1.1 1 0 0 1 1 1 1 Giardia variant-specific surface protein TNFR_16_TM PF18422.1 EXF85430.1 - 0.0067 16.4 0.2 0.011 15.6 0.2 1.3 1 0 0 1 1 1 1 Tumor necrosis factor receptor member 16 trans-membrane domain DUF3318 PF11780.8 EXF85430.1 - 0.014 15.4 0.1 0.021 14.8 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3318) PTP_tm PF18861.1 EXF85430.1 - 0.015 15.3 0.9 0.026 14.5 0.9 1.3 1 0 0 1 1 1 0 Transmembrane domain of protein tyrosine phosphatase, receptor type J FeoB_associated PF12669.7 EXF85430.1 - 0.018 15.4 0.0 0.031 14.7 0.0 1.4 1 0 0 1 1 1 0 FeoB-associated Cys-rich membrane protein MGC-24 PF05283.11 EXF85430.1 - 0.038 14.4 0.9 0.059 13.8 0.9 1.3 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin TPR_21 PF09976.9 EXF85430.1 - 0.15 11.7 0.0 0.23 11.1 0.0 1.2 1 0 0 1 1 1 0 Tetratricopeptide repeat-like domain SCF PF02404.15 EXF85430.1 - 0.18 11.1 0.0 0.25 10.7 0.0 1.2 1 0 0 1 1 1 0 Stem cell factor Glycoprotein PF03409.15 EXF85430.1 - 0.26 10.1 2.1 0.37 9.6 2.1 1.1 1 0 0 1 1 1 0 Transmembrane glycoprotein DUF4428 PF14471.6 EXF85431.1 - 6.3 6.8 7.0 23 5.0 0.0 4.0 5 0 0 5 5 5 0 Domain of unknown function (DUF4428) Peptidase_S8 PF00082.22 EXF85432.1 - 1.9e-47 162.0 0.9 2.9e-47 161.4 0.2 1.6 2 0 0 2 2 2 1 Subtilase family fn3_5 PF06280.12 EXF85432.1 - 1.9e-06 28.6 0.0 4e-06 27.5 0.0 1.6 1 0 0 1 1 1 1 Fn3-like domain Inhibitor_I9 PF05922.16 EXF85432.1 - 0.06 14.0 0.0 0.14 12.8 0.0 1.6 1 0 0 1 1 1 0 Peptidase inhibitor I9 DAHP_snth_FXD PF18152.1 EXF85432.1 - 0.12 12.2 0.0 0.36 10.7 0.0 1.8 1 0 0 1 1 1 0 DAHP synthase ferredoxin-like domain tRNA-synt_2b PF00587.25 EXF85433.1 - 9.5e-38 129.9 0.0 1.4e-37 129.4 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 EXF85433.1 - 4.4e-18 65.5 7.4 4.4e-18 65.5 7.4 1.6 2 0 0 2 2 2 1 Seryl-tRNA synthetase N-terminal domain Vfa1 PF08432.10 EXF85433.1 - 0.89 9.9 8.9 1.6 9.0 8.9 1.4 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 SHNi-TPR PF10516.9 EXF85434.1 - 7.2e-15 54.2 0.3 7.2e-15 54.2 0.3 2.5 3 0 0 3 3 3 1 SHNi-TPR TPR_12 PF13424.6 EXF85434.1 - 1.6e-09 37.9 0.4 0.00034 20.9 0.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 EXF85434.1 - 9.9e-05 22.0 2.3 0.00068 19.4 0.4 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 EXF85434.1 - 0.00048 20.0 9.8 0.00081 19.3 0.2 3.7 4 0 0 4 4 4 2 Tetratricopeptide repeat UPF0227 PF05728.12 EXF85434.1 - 0.061 13.3 0.2 0.8 9.6 0.0 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0227) TPR_10 PF13374.6 EXF85434.1 - 0.33 10.9 2.2 21 5.1 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF2508 PF10704.9 EXF85434.1 - 0.44 10.7 8.6 4.7 7.5 0.2 3.6 3 1 1 4 4 4 0 Protein of unknown function (DUF2508) TPR_8 PF13181.6 EXF85434.1 - 3.7 8.0 10.6 0.27 11.6 0.4 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat RabGAP-TBC PF00566.18 EXF85435.1 - 1.6e-48 165.2 0.0 5.5e-48 163.5 0.0 1.8 1 1 0 1 1 1 1 Rab-GTPase-TBC domain RRM_1 PF00076.22 EXF85436.1 - 1.5e-34 117.6 0.2 1.7e-16 59.8 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EXF85436.1 - 3.2e-12 46.4 0.1 0.0001 22.4 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif Nup35_RRM_2 PF14605.6 EXF85436.1 - 0.00029 20.8 0.0 0.69 10.0 0.0 2.4 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 EXF85436.1 - 0.13 12.3 0.0 17 5.5 0.0 2.6 2 0 0 2 2 2 0 RNA binding motif DUF4175 PF13779.6 EXF85436.1 - 0.87 7.4 33.9 1.5 6.7 33.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) GCS PF03074.16 EXF85437.1 - 2.8e-173 576.4 0.0 3.4e-173 576.2 0.0 1.1 1 0 0 1 1 1 1 Glutamate-cysteine ligase MFS_1 PF07690.16 EXF85439.1 - 3.8e-11 42.5 41.9 3.8e-11 42.5 41.9 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily UNC-93 PF05978.16 EXF85439.1 - 5e-06 26.3 4.3 5e-06 26.3 4.3 2.7 2 1 1 3 3 3 1 Ion channel regulatory protein UNC-93 GARS_A PF01071.19 EXF85440.1 - 8.5e-83 276.9 0.0 1.5e-82 276.1 0.0 1.4 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain GARS_N PF02844.15 EXF85440.1 - 4.9e-33 113.8 0.0 1.6e-32 112.2 0.0 2.0 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, N domain AIRS_C PF02769.22 EXF85440.1 - 2.4e-32 112.2 0.1 3.2e-31 108.6 0.1 2.5 2 0 0 2 2 2 1 AIR synthase related protein, C-terminal domain GARS_C PF02843.16 EXF85440.1 - 3.9e-25 88.0 1.9 5.6e-25 87.4 0.2 2.3 2 0 0 2 2 1 1 Phosphoribosylglycinamide synthetase, C domain AIRS PF00586.24 EXF85440.1 - 4.5e-13 49.7 1.9 4.5e-13 49.7 1.9 2.5 3 0 0 3 3 1 1 AIR synthase related protein, N-terminal domain TPR_11 PF13414.6 EXF85440.1 - 1.3e-06 28.0 0.4 0.087 12.5 0.0 4.4 4 0 0 4 4 4 2 TPR repeat TPR_20 PF14561.6 EXF85440.1 - 1.7e-05 25.0 1.7 3.8 7.9 0.0 4.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 EXF85440.1 - 3.9e-05 24.2 9.2 0.32 11.7 0.2 6.3 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_19 PF14559.6 EXF85440.1 - 6e-05 23.5 17.9 0.14 12.7 0.0 6.4 6 2 2 8 8 6 2 Tetratricopeptide repeat TPR_17 PF13431.6 EXF85440.1 - 8.2e-05 22.7 0.3 0.22 12.0 0.0 5.1 5 0 0 5 5 4 1 Tetratricopeptide repeat CPSase_L_D2 PF02786.17 EXF85440.1 - 0.00026 20.5 0.2 0.00052 19.6 0.2 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain TPR_2 PF07719.17 EXF85440.1 - 0.0016 18.4 17.7 3 8.2 0.0 7.2 8 0 0 8 8 5 1 Tetratricopeptide repeat ATP-grasp PF02222.22 EXF85440.1 - 0.0019 17.8 0.0 0.0042 16.7 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.14 EXF85440.1 - 0.0058 16.7 0.0 0.013 15.6 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain TPR_9 PF13371.6 EXF85440.1 - 0.0059 16.7 6.7 0.048 13.8 0.1 4.2 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_1 PF00515.28 EXF85440.1 - 0.014 15.2 13.0 4.5 7.3 0.0 6.9 7 0 0 7 7 7 0 Tetratricopeptide repeat ATP-grasp_4 PF13535.6 EXF85440.1 - 0.015 14.9 0.0 0.031 13.9 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp domain TPR_7 PF13176.6 EXF85440.1 - 0.063 13.3 9.8 26 5.1 0.0 6.0 6 0 0 6 6 6 0 Tetratricopeptide repeat DUF2989 PF11207.8 EXF85440.1 - 0.13 12.0 0.5 0.27 11.0 0.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2989) TPR_14 PF13428.6 EXF85440.1 - 0.17 12.8 21.3 7 7.7 0.1 8.1 6 2 5 11 11 8 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EXF85440.1 - 0.2 11.9 12.2 0.42 10.9 3.4 3.8 5 0 0 5 5 3 0 Anaphase-promoting complex, cyclosome, subunit 3 RimK PF08443.11 EXF85440.1 - 0.2 11.2 0.4 0.39 10.3 0.0 1.6 2 0 0 2 2 1 0 RimK-like ATP-grasp domain TPR_12 PF13424.6 EXF85440.1 - 0.27 11.5 11.2 0.036 14.4 0.8 4.5 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_8 PF13181.6 EXF85440.1 - 0.79 10.1 9.6 55 4.3 0.5 6.4 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_6 PF13174.6 EXF85440.1 - 2.1 9.2 6.3 1.1e+02 3.8 0.2 5.8 5 0 0 5 5 5 0 Tetratricopeptide repeat SAM_2 PF07647.17 EXF85441.1 - 2.4e-09 37.2 0.1 4.5e-09 36.3 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 EXF85441.1 - 4.4e-05 23.8 0.3 8.9e-05 22.9 0.3 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) IGR PF09597.10 EXF85441.1 - 0.03 14.4 0.4 0.077 13.1 0.2 1.7 2 0 0 2 2 2 0 IGR protein motif DUF4508 PF14969.6 EXF85441.1 - 0.11 12.8 0.1 0.29 11.4 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4508) Ribosomal_L29e PF01779.17 EXF85442.1 - 8e-23 80.5 8.9 1.2e-22 79.9 8.9 1.3 1 0 0 1 1 1 1 Ribosomal L29e protein family Mito_carr PF00153.27 EXF85443.1 - 6.4e-57 189.5 0.3 7e-20 70.8 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF3147 PF11345.8 EXF85443.1 - 0.093 13.1 0.0 0.27 11.6 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3147) Peptidase_C2 PF00648.21 EXF85444.1 - 7e-30 104.1 0.0 1.1e-29 103.4 0.0 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.22 EXF85444.1 - 5.2e-09 36.5 0.0 8.3e-06 26.1 0.0 3.7 2 1 0 2 2 2 1 Calpain large subunit, domain III zf-C2H2 PF00096.26 EXF85445.1 - 0.00016 21.9 8.0 0.27 11.8 0.1 3.7 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EXF85445.1 - 0.078 13.4 2.8 8.4 7.0 0.2 2.7 2 0 0 2 2 2 0 Zinc-finger double domain DUF4201 PF13870.6 EXF85447.1 - 0.0003 20.6 4.0 0.00042 20.1 2.4 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF4201) Prominin PF05478.11 EXF85447.1 - 0.1 10.5 0.3 0.15 10.0 0.3 1.1 1 0 0 1 1 1 0 Prominin DUF2205 PF10224.9 EXF85447.1 - 0.21 11.6 2.8 0.97 9.5 2.8 2.2 1 0 0 1 1 1 0 Short coiled-coil protein BTB PF00651.31 EXF85448.1 - 0.00021 21.5 0.1 0.00041 20.5 0.1 1.4 1 0 0 1 1 1 1 BTB/POZ domain AHJR-like PF18743.1 EXF85448.1 - 0.11 12.0 0.0 6.3 6.4 0.0 2.3 2 0 0 2 2 2 0 REase_AHJR-like zinc_ribbon_2 PF13240.6 EXF85449.1 - 0.054 13.2 0.9 0.14 11.9 0.9 1.8 1 0 0 1 1 1 0 zinc-ribbon domain DZR PF12773.7 EXF85449.1 - 0.12 12.4 1.5 0.34 11.0 1.5 1.7 1 0 0 1 1 1 0 Double zinc ribbon LicD PF04991.13 EXF85450.1 - 6.1e-22 78.9 6.4 6.1e-17 62.5 1.8 2.3 1 1 1 2 2 2 2 LicD family NUDIX PF00293.28 EXF85451.1 - 5e-07 29.8 0.2 1.2e-06 28.6 0.2 1.7 1 1 0 1 1 1 1 NUDIX domain ER_lumen_recept PF00810.18 EXF85452.1 - 6.6e-40 137.3 8.0 1.1e-39 136.6 8.0 1.4 1 0 0 1 1 1 1 ER lumen protein retaining receptor DUF4234 PF14018.6 EXF85452.1 - 2.2 8.5 13.9 1.3 9.2 1.7 3.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4234) LapA_dom PF06305.11 EXF85454.1 - 0.094 12.5 1.2 0.25 11.2 1.2 1.7 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain adh_short PF00106.25 EXF85455.1 - 7.8e-21 74.4 0.1 1.1e-19 70.7 0.0 2.0 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF85455.1 - 1.8e-12 47.3 1.8 2.8e-11 43.4 1.8 2.1 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF85455.1 - 0.00073 19.5 0.1 0.0013 18.7 0.1 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EXF85455.1 - 0.11 11.9 0.2 0.19 11.2 0.2 1.5 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family ADK PF00406.22 EXF85456.1 - 2.6e-37 128.2 0.0 3.1e-20 72.8 0.0 2.1 2 0 0 2 2 2 2 Adenylate kinase AAA_17 PF13207.6 EXF85456.1 - 3.2e-14 53.5 0.0 4.6e-10 40.1 0.0 2.2 1 1 0 2 2 2 2 AAA domain ADK_lid PF05191.14 EXF85456.1 - 8.9e-14 51.2 0.0 2.1e-13 50.0 0.0 1.7 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_18 PF13238.6 EXF85456.1 - 0.00026 21.6 0.0 0.0017 18.9 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EXF85456.1 - 0.0031 17.7 0.0 0.014 15.5 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 EXF85456.1 - 0.074 13.1 0.0 0.16 11.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Guanylate_kin PF00625.21 EXF85456.1 - 0.14 11.8 0.1 0.37 10.5 0.0 1.7 2 0 0 2 2 2 0 Guanylate kinase LETM1 PF07766.13 EXF85457.1 - 9.4e-106 353.0 0.7 9.4e-106 353.0 0.7 1.5 2 0 0 2 2 2 1 LETM1-like protein SAP PF02037.27 EXF85457.1 - 0.014 15.1 0.1 0.6 9.9 0.0 3.0 3 0 0 3 3 3 0 SAP domain DUF1180 PF06679.12 EXF85457.1 - 3.6 8.0 11.8 0.21 12.0 5.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) PX PF00787.24 EXF85458.1 - 2.7e-21 75.7 0.3 8e-21 74.1 0.3 1.9 1 0 0 1 1 1 1 PX domain Vps5 PF09325.10 EXF85458.1 - 9.3e-10 38.4 12.6 3.4e-06 26.8 2.3 2.4 2 1 0 2 2 2 2 Vps5 C terminal like FtsH_ext PF06480.15 EXF85458.1 - 0.034 14.5 0.4 0.14 12.5 0.0 2.2 2 0 0 2 2 2 0 FtsH Extracellular Occludin_ELL PF07303.13 EXF85458.1 - 0.067 13.9 6.1 0.1 13.3 0.0 3.5 3 2 0 3 3 3 0 Occludin homology domain DUF1664 PF07889.12 EXF85458.1 - 0.1 12.6 3.1 5.7 7.0 0.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Sec34 PF04136.15 EXF85458.1 - 0.1 12.5 0.2 0.1 12.5 0.2 2.2 2 1 0 2 2 2 0 Sec34-like family Sigma70_r1_1 PF03979.14 EXF85458.1 - 2 8.5 6.2 0.17 11.9 0.4 2.3 2 0 0 2 2 2 0 Sigma-70 factor, region 1.1 Peptidase_S8 PF00082.22 EXF85459.1 - 3.1e-36 125.1 2.9 5e-36 124.5 2.9 1.3 1 0 0 1 1 1 1 Subtilase family P_proprotein PF01483.20 EXF85459.1 - 3.5e-27 94.3 2.8 4.2e-27 94.0 1.2 2.0 2 0 0 2 2 2 1 Proprotein convertase P-domain S8_pro-domain PF16470.5 EXF85459.1 - 0.097 13.4 0.0 0.25 12.1 0.0 1.7 1 0 0 1 1 1 0 Peptidase S8 pro-domain PhoD PF09423.10 EXF85460.1 - 3.4e-08 32.9 0.0 6.5e-08 32.0 0.0 1.4 1 0 0 1 1 1 1 PhoD-like phosphatase RRM_1 PF00076.22 EXF85461.1 - 3.8e-13 49.1 0.0 5.8e-13 48.5 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 EXF85461.1 - 0.0049 16.9 0.0 0.0081 16.2 0.0 1.4 1 0 0 1 1 1 1 RNA binding motif HpcH_HpaI PF03328.14 EXF85463.1 - 4.4e-42 143.7 0.0 1e-41 142.5 0.0 1.6 2 0 0 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family C-C_Bond_Lyase PF15617.6 EXF85463.1 - 1.5e-10 40.8 0.0 3.1e-06 26.6 0.0 2.1 2 0 0 2 2 2 2 C-C_Bond_Lyase of the TIM-Barrel fold PK PF00224.21 EXF85463.1 - 0.0012 17.8 0.0 0.0016 17.4 0.0 1.2 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain Malate_synthase PF01274.22 EXF85463.1 - 0.041 12.1 0.0 8 4.6 0.0 2.8 3 0 0 3 3 3 0 Malate synthase PEPcase_2 PF14010.6 EXF85463.1 - 0.049 12.1 0.0 0.086 11.3 0.0 1.3 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxylase DUF846 PF05832.12 EXF85464.1 - 1.4e-42 145.1 6.0 1.6e-42 144.9 6.0 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF846) Cyclin PF08613.11 EXF85465.1 - 3.1e-12 47.2 0.0 6e-12 46.2 0.0 1.5 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 EXF85465.1 - 0.0021 17.8 0.0 0.0034 17.1 0.0 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Chs7 PF12271.8 EXF85467.1 - 4.7e-122 406.9 16.8 5.3e-122 406.7 16.8 1.0 1 0 0 1 1 1 1 Chitin synthase export chaperone DUF3382 PF11862.8 EXF85467.1 - 0.19 12.0 5.8 0.14 12.5 3.4 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF3382) DUF3716 PF12511.8 EXF85468.1 - 2.3e-07 30.8 8.7 3.9e-07 30.0 8.7 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3716) Trypan_PARP PF05887.11 EXF85468.1 - 9.8 6.2 9.3 21 5.1 9.3 1.5 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Acyl_transf_3 PF01757.22 EXF85469.1 - 1.2e-22 80.5 38.3 1.2e-22 80.5 38.3 2.0 2 1 0 2 2 2 1 Acyltransferase family Apq12 PF12716.7 EXF85469.1 - 0.061 13.3 0.5 0.061 13.3 0.5 4.2 5 0 0 5 5 5 0 Nuclear pore assembly and biogenesis Cu_amine_oxid PF01179.20 EXF85470.1 - 6.1e-160 532.6 0.0 9.7e-160 532.0 0.0 1.3 2 0 0 2 2 2 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN2 PF02727.16 EXF85470.1 - 9.3e-08 32.2 0.0 2.2e-07 31.0 0.0 1.6 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain Cu_amine_oxidN3 PF02728.16 EXF85470.1 - 2.4e-05 24.7 0.0 4.9e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 Copper amine oxidase, N3 domain Fungal_trans_2 PF11951.8 EXF85471.1 - 3.9e-33 114.8 6.7 5.4e-33 114.3 6.7 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF85471.1 - 3.5e-08 33.4 9.4 3.5e-08 33.4 9.4 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pro_racemase PF05544.11 EXF85472.1 - 3e-64 217.1 0.0 3.6e-64 216.9 0.0 1.0 1 0 0 1 1 1 1 Proline racemase MFS_1 PF07690.16 EXF85473.1 - 1.3e-20 73.6 55.6 5e-19 68.4 29.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF85473.1 - 9.7e-05 21.4 31.1 0.00058 18.9 1.0 3.2 3 0 0 3 3 3 2 Sugar (and other) transporter TssN PF17555.2 EXF85473.1 - 0.02 14.3 0.3 0.02 14.3 0.3 2.0 2 0 0 2 2 2 0 Type VI secretion system, TssN Peptidase_M56 PF05569.11 EXF85473.1 - 0.054 12.7 0.5 0.71 9.0 0.0 2.4 2 0 0 2 2 2 0 BlaR1 peptidase M56 MFS_1 PF07690.16 EXF85474.1 - 3.6e-33 115.0 14.6 3.6e-33 115.0 14.6 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF85474.1 - 5.3e-06 25.6 3.8 1.1e-05 24.5 3.8 1.5 1 0 0 1 1 1 1 Sugar (and other) transporter ADH_zinc_N_2 PF13602.6 EXF85475.1 - 1.2e-10 42.6 0.0 2.9e-10 41.3 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EXF85475.1 - 2.8e-07 30.4 0.0 7.7e-07 29.0 0.0 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EXF85475.1 - 1.6e-06 28.1 0.0 3.5e-06 27.0 0.0 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Aa_trans PF01490.18 EXF85476.1 - 1.7e-49 168.6 38.3 2e-49 168.4 38.3 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein 4HBT_3 PF13622.6 EXF85477.1 - 3.2e-51 175.0 0.0 3.8e-51 174.7 0.0 1.0 1 0 0 1 1 1 1 Thioesterase-like superfamily Acyl_CoA_thio PF02551.15 EXF85477.1 - 0.003 17.4 0.0 0.0049 16.7 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA thioesterase Tyrosinase PF00264.20 EXF85478.1 - 1.8e-41 142.8 1.4 3.2e-41 142.0 1.4 1.4 1 0 0 1 1 1 1 Common central domain of tyrosinase GvpO PF05800.11 EXF85478.1 - 0.075 13.0 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpO Polysacc_deac_1 PF01522.21 EXF85480.1 - 6.3e-29 100.4 0.0 1e-28 99.7 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase Chitin_bind_1 PF00187.19 EXF85480.1 - 7.6e-24 83.9 71.2 1.6e-09 38.1 21.8 3.6 3 0 0 3 3 3 3 Chitin recognition protein Glyco_hydro_57 PF03065.15 EXF85480.1 - 0.015 14.5 0.0 0.045 12.9 0.0 1.8 1 1 1 2 2 2 0 Glycosyl hydrolase family 57 DUF2334 PF10096.9 EXF85480.1 - 0.026 14.2 0.1 0.036 13.7 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2334) Chitin_synth_2 PF03142.15 EXF85481.1 - 1.1e-42 146.4 3.8 1.2e-32 113.3 0.9 2.4 2 1 0 2 2 2 2 Chitin synthase Glycos_transf_2 PF00535.26 EXF85481.1 - 1.9e-07 31.0 0.0 0.01 15.7 0.0 2.4 2 0 0 2 2 2 2 Glycosyl transferase family 2 Glyco_trans_2_3 PF13632.6 EXF85481.1 - 0.0002 21.3 11.6 0.0004 20.4 5.8 3.2 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 EXF85481.1 - 0.00059 19.8 0.0 2 8.2 0.0 3.0 3 0 0 3 3 3 2 Glycosyltransferase like family 2 RCDG1 PF15725.5 EXF85481.1 - 8.6 6.9 8.5 22 5.5 8.5 1.6 1 0 0 1 1 1 0 Renal cancer differentiation gene 1 protein Polysacc_deac_1 PF01522.21 EXF85482.1 - 5e-25 87.8 0.0 9.2e-25 86.9 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide deacetylase Chitin_bind_1 PF00187.19 EXF85482.1 - 4.6e-16 59.0 83.9 1.2e-06 28.9 16.3 3.8 3 1 1 4 4 4 3 Chitin recognition protein DUF2334 PF10096.9 EXF85482.1 - 0.0048 16.6 0.0 0.008 15.8 0.0 1.3 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2334) Med3 PF11593.8 EXF85482.1 - 1 8.5 9.5 1.6 7.8 9.5 1.3 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal UDPG_MGDP_dh PF00984.19 EXF85484.1 - 4.9e-19 68.3 0.0 1.1e-18 67.2 0.0 1.6 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain UDPG_MGDP_dh_N PF03721.14 EXF85484.1 - 4.4e-16 59.0 0.0 1.8e-13 50.5 0.0 2.3 1 1 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_binding_2 PF03446.15 EXF85484.1 - 2e-06 28.1 0.0 3.6e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase UDPG_MGDP_dh_C PF03720.15 EXF85484.1 - 0.0063 16.9 0.0 0.012 16.0 0.0 1.5 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain TrkA_N PF02254.18 EXF85484.1 - 0.15 12.3 0.0 0.31 11.3 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain PH_12 PF16457.5 EXF85485.1 - 0.16 12.5 1.1 0.22 12.1 0.5 1.7 1 1 0 1 1 1 0 Pleckstrin homology domain Astro_capsid_p PF12226.8 EXF85485.1 - 0.17 11.0 1.3 0.3 10.2 1.3 1.3 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Nucleo_P87 PF07267.11 EXF85485.1 - 2.3 7.0 8.4 3.1 6.5 8.4 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 PX PF00787.24 EXF85486.1 - 2.4e-18 66.2 0.1 4.6e-18 65.2 0.1 1.4 1 0 0 1 1 1 1 PX domain Ribosomal_L27A PF00828.19 EXF85487.1 - 3.9e-31 108.4 1.1 5.9e-31 107.8 1.1 1.3 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A adh_short PF00106.25 EXF85488.1 - 6.5e-23 81.2 0.0 8.9e-23 80.8 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF85488.1 - 1.6e-12 47.5 0.0 2.1e-12 47.1 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF85488.1 - 0.029 14.3 0.0 0.065 13.1 0.1 1.6 2 0 0 2 2 2 0 KR domain 3HCDH_N PF02737.18 EXF85488.1 - 0.17 11.7 0.1 2.4 8.0 0.0 2.2 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Glyco_transf_15 PF01793.16 EXF85489.1 - 4.9e-95 318.5 7.2 5.5e-94 315.0 7.2 1.9 1 1 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase Pex26 PF07163.12 EXF85489.1 - 0.23 10.8 0.1 0.32 10.2 0.1 1.1 1 0 0 1 1 1 0 Pex26 protein ILVD_EDD PF00920.21 EXF85490.1 - 2.6e-208 692.8 0.5 3.1e-208 692.6 0.5 1.0 1 0 0 1 1 1 1 Dehydratase family GFA PF04828.14 EXF85491.1 - 1.7e-09 37.9 0.2 1.7e-09 37.9 0.2 1.6 2 0 0 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme PTR2 PF00854.21 EXF85493.1 - 4.2e-75 253.0 8.8 5.8e-75 252.6 8.8 1.2 1 0 0 1 1 1 1 POT family MFS_1_like PF12832.7 EXF85493.1 - 0.0023 16.9 3.5 0.0079 15.1 0.3 2.7 2 1 0 2 2 2 1 MFS_1 like family DAP_epimerase PF01678.19 EXF85493.1 - 0.17 12.0 0.0 0.36 11.0 0.0 1.5 1 0 0 1 1 1 0 Diaminopimelate epimerase 2-Hacid_dh_C PF02826.19 EXF85495.1 - 3.3e-46 156.9 0.0 4.7e-46 156.4 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EXF85495.1 - 1.8e-07 30.9 0.0 3.4e-07 30.0 0.0 1.4 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 EXF85495.1 - 0.021 15.0 0.2 0.044 14.0 0.1 1.6 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase IlvN PF07991.12 EXF85495.1 - 0.031 13.8 0.0 0.049 13.2 0.0 1.3 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain Fungal_trans_2 PF11951.8 EXF85496.1 - 7.5e-06 25.0 0.0 1.2e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain F-box-like PF12937.7 EXF85497.1 - 0.0065 16.3 0.2 0.016 15.1 0.2 1.8 1 0 0 1 1 1 1 F-box-like F-box-like PF12937.7 EXF85498.1 - 0.045 13.6 0.1 0.1 12.5 0.1 1.6 1 0 0 1 1 1 0 F-box-like adh_short PF00106.25 EXF85500.1 - 8.2e-35 120.0 0.1 1e-34 119.7 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF85500.1 - 1.1e-31 110.2 0.2 1.3e-31 110.0 0.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF85500.1 - 7.6e-10 39.0 0.3 2.6e-09 37.2 0.3 1.9 1 1 0 1 1 1 1 KR domain 3Beta_HSD PF01073.19 EXF85500.1 - 0.0012 17.9 0.1 0.0021 17.1 0.1 1.4 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Flu_PB1 PF00602.17 EXF85500.1 - 0.021 12.9 0.4 0.038 12.1 0.0 1.5 2 0 0 2 2 2 0 Influenza RNA-dependent RNA polymerase subunit PB1 Epimerase PF01370.21 EXF85500.1 - 0.1 12.0 0.0 0.33 10.4 0.0 1.7 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family Ras PF00071.22 EXF85501.1 - 7.5e-43 145.9 0.0 1.3e-42 145.1 0.0 1.4 1 1 0 1 1 1 1 Ras family Roc PF08477.13 EXF85501.1 - 5e-30 104.2 0.0 7.4e-30 103.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EXF85501.1 - 7.4e-11 41.8 0.0 2.7e-10 40.0 0.0 1.7 2 0 0 2 2 2 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EXF85501.1 - 0.00028 20.9 0.0 0.00054 20.0 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_33 PF13671.6 EXF85501.1 - 0.0025 18.0 0.0 0.0039 17.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain Gtr1_RagA PF04670.12 EXF85501.1 - 0.0048 16.3 0.0 0.0062 15.9 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 EXF85501.1 - 0.017 14.6 0.0 0.024 14.1 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 EXF85501.1 - 0.02 14.4 0.0 0.099 12.2 0.0 2.1 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EXF85501.1 - 0.022 14.7 0.0 0.1 12.5 0.0 2.0 1 1 1 2 2 2 0 RsgA GTPase PduV-EutP PF10662.9 EXF85501.1 - 0.031 14.0 0.0 0.58 9.9 0.0 2.2 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_28 PF13521.6 EXF85501.1 - 0.051 13.8 0.0 0.074 13.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EXF85501.1 - 0.078 13.3 0.0 0.13 12.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EXF85501.1 - 0.1 13.0 0.0 0.17 12.2 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.27 EXF85501.1 - 0.14 12.7 0.0 0.25 11.9 0.0 1.4 1 0 0 1 1 1 0 ABC transporter AAA_7 PF12775.7 EXF85501.1 - 0.15 11.6 0.0 0.23 10.9 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region Tropomodulin PF03250.14 EXF85501.1 - 0.18 11.8 0.0 0.29 11.2 0.0 1.2 1 0 0 1 1 1 0 Tropomodulin Mannosidase_ig PF17786.1 EXF85502.1 - 4.4e-17 62.5 0.2 1.5e-16 60.7 0.1 2.1 2 0 0 2 2 2 1 Mannosidase Ig/CBM-like domain Glyco_hydro_2 PF00703.21 EXF85502.1 - 3.5e-11 43.8 0.0 1.1e-10 42.1 0.0 1.9 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 Ig_mannosidase PF17753.1 EXF85502.1 - 2.5e-07 30.4 0.0 7e-07 28.9 0.0 1.7 1 0 0 1 1 1 1 Ig-fold domain Glyco_hydro_2_N PF02837.18 EXF85502.1 - 0.00097 19.1 0.0 0.0025 17.7 0.0 1.7 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2_C PF02836.17 EXF85502.1 - 0.0011 18.2 1.3 0.0088 15.2 1.3 2.0 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Ig_GlcNase PF18368.1 EXF85502.1 - 0.12 12.5 0.1 0.71 10.1 0.0 2.3 3 0 0 3 3 3 0 Exo-beta-D-glucosaminidase Ig-fold domain AP_endonuc_2 PF01261.24 EXF85503.1 - 5.6e-08 32.5 0.0 1.6e-07 31.0 0.0 1.7 1 1 0 1 1 1 1 Xylose isomerase-like TIM barrel IMS PF00817.20 EXF85504.1 - 1.3e-39 135.6 0.0 2.2e-39 134.8 0.0 1.4 1 0 0 1 1 1 1 impB/mucB/samB family zf_UBZ PF18439.1 EXF85504.1 - 1.5e-12 46.9 1.6 3.2e-12 45.8 1.6 1.6 1 0 0 1 1 1 1 Ubiquitin-Binding Zinc Finger IMS_C PF11799.8 EXF85504.1 - 7.2e-12 46.1 0.2 1.2e-10 42.0 0.0 2.8 3 0 0 3 3 3 1 impB/mucB/samB family C-terminal domain NAD_binding_10 PF13460.6 EXF85505.1 - 4.6e-05 23.4 0.0 4.8e-05 23.3 0.0 1.1 1 0 0 1 1 1 1 NAD(P)H-binding KR PF08659.10 EXF85505.1 - 0.0011 18.9 0.0 0.0015 18.5 0.0 1.2 1 0 0 1 1 1 1 KR domain NmrA PF05368.13 EXF85505.1 - 0.0032 17.1 0.0 0.0041 16.7 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family Epimerase PF01370.21 EXF85505.1 - 0.0035 16.9 0.0 0.0046 16.5 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family DapB_N PF01113.20 EXF85505.1 - 0.043 13.9 0.0 0.059 13.5 0.0 1.1 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus ADH_N PF08240.12 EXF85506.1 - 9e-30 102.8 0.4 2.4e-29 101.4 0.1 1.9 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EXF85506.1 - 1.2e-22 80.3 0.1 1.9e-22 79.7 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EXF85506.1 - 4.8e-09 36.0 0.3 7.5e-09 35.4 0.3 1.3 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus AlaDh_PNT_C PF01262.21 EXF85506.1 - 4.1e-06 26.2 1.3 6e-06 25.7 1.3 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain ADH_zinc_N_2 PF13602.6 EXF85506.1 - 0.00014 22.9 0.0 0.00056 21.0 0.0 2.0 1 1 1 2 2 2 1 Zinc-binding dehydrogenase Pyr_redox_2 PF07992.14 EXF85506.1 - 0.0029 16.9 0.3 0.0059 15.9 0.3 1.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase UDPG_MGDP_dh_N PF03721.14 EXF85506.1 - 0.0053 16.3 0.1 0.011 15.3 0.0 1.6 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain AdoHcyase_NAD PF00670.21 EXF85506.1 - 0.041 13.9 0.1 0.53 10.4 0.2 2.2 2 0 0 2 2 2 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain HI0933_like PF03486.14 EXF85506.1 - 0.046 12.4 0.3 0.067 11.9 0.3 1.2 1 0 0 1 1 1 0 HI0933-like protein Methyltransf_25 PF13649.6 EXF85506.1 - 0.1 13.3 0.1 0.2 12.4 0.1 1.5 1 0 0 1 1 1 0 Methyltransferase domain 2-Hacid_dh_C PF02826.19 EXF85506.1 - 0.12 11.8 0.1 0.22 10.8 0.1 1.5 1 1 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain FtsJ PF01728.19 EXF85506.1 - 0.13 12.3 0.1 0.22 11.6 0.1 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase MARVEL PF01284.23 EXF85507.1 - 1.1e-07 31.9 14.4 1.1e-07 31.9 14.4 2.2 1 1 1 2 2 2 1 Membrane-associating domain Lin-8 PF03353.15 EXF85507.1 - 2 7.9 23.3 0.064 12.8 14.6 2.0 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist Neur_chan_memb PF02932.16 EXF85507.1 - 7.8 6.5 7.0 2.6 8.0 3.5 1.9 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region DUF1015 PF06245.11 EXF85508.1 - 0.088 11.7 0.0 0.11 11.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1015) zf-TRAF PF02176.18 EXF85508.1 - 0.13 13.0 1.5 3.7 8.3 0.1 2.5 2 0 0 2 2 2 0 TRAF-type zinc finger IAT_beta PF11924.8 EXF85508.1 - 0.28 10.6 1.8 10 5.4 0.2 2.1 1 1 1 2 2 2 0 Inverse autotransporter, beta-domain GLEYA PF10528.9 EXF85509.1 - 9.3e-27 93.3 4.9 9.3e-27 93.3 4.9 2.2 2 0 0 2 2 2 1 GLEYA domain PA14 PF07691.12 EXF85509.1 - 4.4e-09 36.3 0.2 1.2e-08 34.9 0.2 1.7 1 0 0 1 1 1 1 PA14 domain DUF1180 PF06679.12 EXF85510.1 - 1.9 8.9 3.3 2.4 8.5 3.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) SOG2 PF10428.9 EXF85512.1 - 3 6.9 5.2 3.5 6.7 5.2 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein zf-RING_2 PF13639.6 EXF85513.1 - 2.2e-11 43.9 3.9 4.4e-11 42.9 3.9 1.5 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 EXF85513.1 - 5.5e-10 39.4 2.8 1.3e-09 38.2 2.8 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 EXF85513.1 - 4.3e-07 29.9 0.4 8.6e-07 28.9 0.4 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_2 PF13923.6 EXF85513.1 - 5.1e-06 26.2 5.9 1.7e-05 24.6 5.9 1.9 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EXF85513.1 - 1.6e-05 24.8 2.8 2.6e-05 24.1 2.8 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 EXF85513.1 - 6.4e-05 22.7 3.2 0.00011 22.0 3.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EXF85513.1 - 9.2e-05 22.2 2.8 0.0002 21.1 2.8 1.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EXF85513.1 - 0.00036 20.3 3.5 0.0007 19.4 3.5 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 EXF85513.1 - 0.00066 19.6 3.9 0.0015 18.5 3.9 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_11 PF17123.5 EXF85513.1 - 0.0021 17.8 0.7 0.0057 16.4 0.7 1.7 1 1 0 1 1 1 1 RING-like zinc finger FANCL_C PF11793.8 EXF85513.1 - 0.015 15.5 4.6 0.26 11.5 4.6 2.3 1 1 0 1 1 1 0 FANCL C-terminal domain Zn_ribbon_17 PF17120.5 EXF85513.1 - 0.072 12.7 5.6 0.16 11.6 5.6 1.6 1 1 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-Nse PF11789.8 EXF85513.1 - 0.31 10.9 2.1 0.84 9.5 2.1 1.7 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4_4 PF15227.6 EXF85513.1 - 2.9 8.1 4.8 0.5 10.6 1.1 1.6 2 0 0 2 2 1 0 zinc finger of C3HC4-type, RING Cullin PF00888.22 EXF85514.1 - 4.2e-23 81.8 0.0 8.4e-23 80.8 0.0 1.4 1 0 0 1 1 1 1 Cullin family ANAPC2 PF08672.11 EXF85514.1 - 3.5e-20 72.3 0.7 1.5e-19 70.2 0.3 2.4 2 0 0 2 2 2 1 Anaphase promoting complex (APC) subunit 2 zf-C2H2 PF00096.26 EXF85515.1 - 0.0046 17.3 3.7 0.4 11.2 0.4 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EXF85515.1 - 0.027 15.3 2.0 10 7.2 0.2 2.9 2 0 0 2 2 2 0 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EXF85515.1 - 0.13 12.8 1.9 0.13 12.7 0.0 2.1 2 0 0 2 2 2 0 Zinc-finger double domain MCM PF00493.23 EXF85518.1 - 1.7e-99 331.5 0.6 2.4e-99 331.0 0.0 1.6 2 0 0 2 2 2 1 MCM P-loop domain MCM_OB PF17207.3 EXF85518.1 - 7.9e-39 132.4 0.1 1.5e-38 131.5 0.1 1.4 1 0 0 1 1 1 1 MCM OB domain MCM2_N PF12619.8 EXF85518.1 - 2.8e-32 112.1 33.2 2.8e-32 112.1 33.2 2.6 4 0 0 4 4 4 1 Mini-chromosome maintenance protein 2 MCM_lid PF17855.1 EXF85518.1 - 5.7e-26 90.8 1.2 1.7e-25 89.2 1.2 1.9 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 EXF85518.1 - 5.4e-14 52.6 0.2 1.5e-13 51.2 0.2 1.8 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 EXF85518.1 - 8.4e-08 31.8 0.0 5.9e-06 25.8 0.0 2.7 1 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EXF85518.1 - 1.8e-06 28.0 0.0 4.5e-06 26.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 EXF85518.1 - 0.003 17.4 0.1 0.014 15.2 0.0 2.1 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EXF85518.1 - 0.0035 17.1 0.2 0.024 14.3 0.2 2.0 1 1 0 1 1 1 1 Sigma-54 interaction domain Zn_ribbon_2 PF12674.7 EXF85518.1 - 0.063 13.9 0.5 0.19 12.4 0.5 1.8 1 0 0 1 1 1 0 Putative zinc ribbon domain zf-TFIIB PF13453.6 EXF85518.1 - 0.12 11.7 1.7 0.28 10.6 1.7 1.6 1 0 0 1 1 1 0 Transcription factor zinc-finger zf-UBR PF02207.20 EXF85519.1 - 1e-13 51.2 5.9 1e-13 51.2 5.9 3.3 4 0 0 4 4 4 1 Putative zinc finger in N-recognin (UBR box) DEC-1_N PF04625.13 EXF85519.1 - 0.33 9.9 7.3 0.65 8.9 7.0 1.6 1 1 0 1 1 1 0 DEC-1 protein, N-terminal region AA_permease PF00324.21 EXF85520.1 - 1.7e-104 350.1 36.5 2e-104 349.8 36.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EXF85520.1 - 4.4e-33 114.7 41.9 5.4e-33 114.5 41.9 1.0 1 0 0 1 1 1 1 Amino acid permease DUF2353 PF09789.9 EXF85521.1 - 0.0031 16.9 4.6 0.005 16.2 4.6 1.4 1 1 0 1 1 1 1 Uncharacterized coiled-coil protein (DUF2353) DUF4763 PF15960.5 EXF85521.1 - 0.043 13.1 0.2 0.043 13.1 0.2 1.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4763) DUF4726 PF15855.5 EXF85521.1 - 0.058 13.6 3.2 0.14 12.4 0.1 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4726) FlgN PF05130.12 EXF85521.1 - 0.073 13.6 0.5 0.073 13.6 0.5 2.4 2 1 1 3 3 3 0 FlgN protein E2F_CC-MB PF16421.5 EXF85521.1 - 0.27 11.6 2.5 0.34 11.3 0.1 2.3 2 0 0 2 2 2 0 E2F transcription factor CC-MB domain Phage_lysis PF03245.13 EXF85521.1 - 1.9 8.6 7.8 0.91 9.7 0.6 3.3 2 1 1 4 4 4 0 Bacteriophage Rz lysis protein Rootletin PF15035.6 EXF85521.1 - 8.5 6.3 18.5 6.6 6.7 14.0 2.7 2 1 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion EBV-NA3 PF05009.12 EXF85522.1 - 0.23 11.0 1.2 0.62 9.6 1.2 1.7 1 0 0 1 1 1 0 Epstein-Barr virus nuclear antigen 3 (EBNA-3) Glyco_hydro_31 PF01055.26 EXF85523.1 - 2.6e-156 521.2 1.7 3.3e-156 520.9 1.7 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.5 EXF85523.1 - 4.5e-39 133.2 0.0 8.3e-39 132.4 0.0 1.4 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Gal_mutarotas_2 PF13802.6 EXF85523.1 - 1.2e-14 54.4 4.0 2.1e-14 53.6 1.6 2.7 3 0 0 3 3 3 1 Galactose mutarotase-like Glyco_hydro_43 PF04616.14 EXF85524.1 - 1.2e-18 67.5 4.3 2.1e-18 66.6 4.3 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 Fungal_trans PF04082.18 EXF85526.1 - 5.3e-13 48.6 1.9 8.8e-13 47.9 1.9 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain CAP_N PF01213.19 EXF85526.1 - 7.1 6.0 6.3 6 6.3 2.2 2.5 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal NAD_binding_10 PF13460.6 EXF85527.1 - 3.7e-21 75.9 0.1 4.8e-21 75.5 0.1 1.1 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EXF85527.1 - 9e-07 28.6 0.0 1.9e-06 27.5 0.0 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EXF85527.1 - 0.00043 19.8 0.0 0.00072 19.0 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 EXF85527.1 - 0.034 13.2 0.0 0.08 12.0 0.0 1.5 1 1 0 1 1 1 0 RmlD substrate binding domain DIOX_N PF14226.6 EXF85528.1 - 7.3e-05 23.5 0.2 0.00026 21.7 0.0 2.1 2 1 0 2 2 2 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EXF85528.1 - 7.7e-05 23.1 0.0 0.0002 21.8 0.0 1.7 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily PIGA PF08288.12 EXF85529.1 - 2.3e-44 149.9 3.1 4.8e-44 148.9 1.0 2.3 2 0 0 2 2 2 1 PIGA (GPI anchor biosynthesis) Glyco_transf_4 PF13439.6 EXF85529.1 - 9.6e-29 100.5 0.4 1.5e-28 99.9 0.4 1.3 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glycos_transf_1 PF00534.20 EXF85529.1 - 1.1e-27 96.6 0.0 1.6e-27 96.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EXF85529.1 - 3.7e-23 82.4 0.1 7.6e-23 81.4 0.1 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 EXF85529.1 - 2e-11 44.6 0.0 3.6e-11 43.8 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_4_2 PF13477.6 EXF85529.1 - 5.2e-07 29.8 0.1 1e-06 28.8 0.1 1.4 1 0 0 1 1 1 1 Glycosyl transferase 4-like Glyco_trans_1_2 PF13524.6 EXF85529.1 - 3.7e-06 27.2 0.0 2.4e-05 24.6 0.0 2.2 2 0 0 2 2 2 1 Glycosyl transferases group 1 DEAD PF00270.29 EXF85530.1 - 2.1e-32 112.3 0.1 1.1e-16 61.2 0.0 2.4 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.31 EXF85530.1 - 1.2e-19 70.7 0.0 4e-19 69.0 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EXF85530.1 - 8.8e-09 35.6 1.8 2e-07 31.1 0.0 2.6 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit DDHD PF02862.17 EXF85530.1 - 0.022 14.9 5.1 0.57 10.3 1.5 2.7 2 0 0 2 2 2 0 DDHD domain UvrD-helicase PF00580.21 EXF85530.1 - 0.023 14.2 0.0 0.023 14.2 0.0 2.3 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain BUD22 PF09073.10 EXF85530.1 - 0.11 11.8 44.7 0.1 12.0 21.2 2.6 3 0 0 3 3 3 0 BUD22 PAC4 PF16093.5 EXF85530.1 - 1.5 9.0 4.0 7.4 6.8 4.1 2.1 2 0 0 2 2 2 0 Proteasome assembly chaperone 4 UL73_N PF12522.8 EXF85530.1 - 3.7 7.4 7.2 14 5.5 7.2 2.1 1 0 0 1 1 1 0 Cytomegalovirus glycoprotein N terminal NARP1 PF12569.8 EXF85530.1 - 7.3 5.4 25.7 11 4.8 25.7 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Colipase-like PF15083.6 EXF85531.1 - 0.068 13.3 0.4 0.1 12.8 0.4 1.2 1 0 0 1 1 1 0 Colipase-like Toxin_18 PF08087.11 EXF85531.1 - 1.3 9.1 6.9 0.67 10.0 0.4 2.4 2 0 0 2 2 2 0 Conotoxin O-superfamily Acetyltransf_1 PF00583.25 EXF85532.1 - 2.1e-09 37.6 0.0 3.6e-09 36.9 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EXF85532.1 - 4.1e-08 33.2 0.0 1e-07 31.9 0.0 1.6 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EXF85532.1 - 5.1e-08 33.2 0.0 1.2e-07 32.1 0.0 1.6 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EXF85532.1 - 2.4e-06 27.4 0.0 4.5e-06 26.5 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 EXF85532.1 - 2.2e-05 24.5 0.0 3.2e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EXF85532.1 - 0.0016 18.5 0.0 0.0036 17.4 0.0 1.5 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase NMT PF01233.19 EXF85532.1 - 0.029 14.2 0.0 0.056 13.3 0.0 1.5 1 0 0 1 1 1 0 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain Thiolase_N PF00108.23 EXF85533.1 - 1e-15 57.8 0.3 2.3e-14 53.4 0.2 2.7 2 1 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EXF85533.1 - 2.2e-13 49.9 3.3 3.5e-13 49.3 0.7 2.6 2 1 1 3 3 3 1 Thiolase, C-terminal domain ACP_syn_III PF08545.10 EXF85533.1 - 4.2e-07 29.7 0.3 1.7e-05 24.6 0.1 2.5 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III ketoacyl-synt PF00109.26 EXF85533.1 - 2.3e-05 24.1 0.0 5.6e-05 22.9 0.0 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 EXF85533.1 - 0.0042 17.1 0.1 0.31 11.1 0.0 3.0 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain SpoVAD PF07451.11 EXF85533.1 - 0.032 13.0 2.2 0.13 10.9 0.2 2.6 3 0 0 3 3 3 0 Stage V sporulation protein AD (SpoVAD) FAD_binding_3 PF01494.19 EXF85534.1 - 4e-22 79.0 0.0 2e-21 76.6 0.0 1.8 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.24 EXF85534.1 - 4.3e-10 39.7 4.0 0.00016 21.4 0.3 2.2 1 1 1 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EXF85534.1 - 9.4e-08 31.6 0.0 0.0028 16.9 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EXF85534.1 - 7.4e-07 28.5 0.0 0.00026 20.2 0.0 2.2 2 0 0 2 2 2 2 Lycopene cyclase protein Pyr_redox PF00070.27 EXF85534.1 - 0.00011 22.7 0.0 0.29 11.7 0.0 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase SE PF08491.10 EXF85534.1 - 0.0002 20.5 0.0 0.02 14.0 0.0 2.3 2 0 0 2 2 2 1 Squalene epoxidase NAD_binding_8 PF13450.6 EXF85534.1 - 0.00092 19.4 0.1 0.0025 18.0 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 EXF85534.1 - 0.0048 15.7 0.2 2.1 6.9 0.0 2.1 2 0 0 2 2 2 2 HI0933-like protein FAD_binding_2 PF00890.24 EXF85534.1 - 0.0066 15.6 0.1 0.014 14.5 0.1 1.6 1 0 0 1 1 1 1 FAD binding domain Trp_halogenase PF04820.14 EXF85534.1 - 0.033 13.0 0.1 3.2 6.5 0.0 2.1 2 0 0 2 2 2 0 Tryptophan halogenase Phenol_hyd_sub PF06099.11 EXF85534.1 - 0.14 12.2 1.0 0.26 11.4 1.0 1.4 1 0 0 1 1 1 0 Phenol hydroxylase subunit NAD_binding_9 PF13454.6 EXF85534.1 - 0.2 11.6 0.4 3.6 7.6 0.2 2.3 2 0 0 2 2 2 0 FAD-NAD(P)-binding FOP_dimer PF09398.10 EXF85537.1 - 0.15 12.3 0.0 0.29 11.4 0.0 1.5 1 0 0 1 1 1 0 FOP N terminal dimerisation domain COesterase PF00135.28 EXF85538.1 - 1e-86 291.8 0.4 1.4e-70 238.7 0.0 2.0 1 1 1 2 2 2 2 Carboxylesterase family Abhydrolase_3 PF07859.13 EXF85538.1 - 0.00027 20.8 0.0 0.00097 19.0 0.0 1.9 2 1 0 2 2 2 1 alpha/beta hydrolase fold Sugar_tr PF00083.24 EXF85540.1 - 5e-75 253.1 25.2 5.9e-75 252.9 25.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF85540.1 - 1.5e-22 80.1 23.6 2.3e-22 79.4 23.6 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_1_like PF12832.7 EXF85540.1 - 1.9e-07 30.3 0.7 1.9e-07 30.3 0.7 2.1 2 0 0 2 2 2 1 MFS_1 like family Phage_holin_2_4 PF16082.5 EXF85540.1 - 0.061 13.1 0.7 0.54 10.0 0.1 2.5 2 0 0 2 2 2 0 Bacteriophage holin family, superfamily II-like DUF2852 PF11014.8 EXF85540.1 - 0.15 12.2 0.6 0.68 10.1 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2852) Peptidase_S8 PF00082.22 EXF85541.1 - 5.5e-41 140.8 4.1 9.5e-41 140.0 4.1 1.3 1 0 0 1 1 1 1 Subtilase family fn3_5 PF06280.12 EXF85541.1 - 2.7e-06 28.0 0.0 6.5e-06 26.8 0.0 1.7 1 0 0 1 1 1 1 Fn3-like domain PG_isomerase_N PF18353.1 EXF85541.1 - 1.2 9.6 5.1 2.6 8.5 0.2 2.5 2 0 0 2 2 2 0 Phosphoglucose isomerase N-terminal domain MFS_1 PF07690.16 EXF85543.1 - 9e-40 136.7 46.7 1.1e-24 87.0 19.9 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF85543.1 - 0.00043 19.3 38.7 0.0014 17.5 19.1 2.8 2 2 0 2 2 2 2 Sugar (and other) transporter MFS_1_like PF12832.7 EXF85543.1 - 0.02 13.8 19.8 0.089 11.6 4.3 2.6 2 1 0 2 2 2 0 MFS_1 like family SVM_signal PF12113.8 EXF85543.1 - 0.14 12.0 0.2 0.14 12.0 0.2 2.2 2 0 0 2 2 2 0 SVM protein signal sequence Glyco_hydro_71 PF03659.14 EXF85544.1 - 5.6e-54 183.4 4.8 6.7e-30 104.1 1.9 2.7 2 1 1 3 3 3 2 Glycosyl hydrolase family 71 Lipase_GDSL_2 PF13472.6 EXF85545.1 - 2.6e-06 28.0 0.8 7.7e-06 26.4 0.8 1.8 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EXF85545.1 - 0.00012 22.1 0.0 0.00015 21.8 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase ADH_zinc_N PF00107.26 EXF85547.1 - 3.8e-08 33.4 0.1 7.5e-08 32.4 0.1 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EXF85547.1 - 7.9e-08 32.2 0.1 5.6e-07 29.4 0.1 2.1 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain Chloroa_b-bind PF00504.21 EXF85548.1 - 4.9 7.7 5.1 5.6 7.5 0.2 3.0 2 1 0 2 2 2 0 Chlorophyll A-B binding protein Pec_lyase_C PF00544.19 EXF85549.1 - 5.1e-18 65.4 7.6 2.7e-16 59.8 7.6 2.3 1 1 0 1 1 1 1 Pectate lyase CBM_1 PF00734.18 EXF85549.1 - 4.9e-12 45.6 10.3 4.9e-12 45.6 10.3 2.3 2 0 0 2 2 2 1 Fungal cellulose binding domain Beta_helix PF13229.6 EXF85549.1 - 3.5e-05 23.7 11.5 0.00026 20.9 9.7 2.2 1 1 1 2 2 2 2 Right handed beta helix region DUF5427 PF10310.9 EXF85549.1 - 1.6 7.6 11.4 2.4 7.0 11.4 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5427) FAM220 PF15487.6 EXF85549.1 - 3.7 7.1 8.4 10 5.6 8.4 1.8 1 0 0 1 1 1 0 FAM220 family SOG2 PF10428.9 EXF85549.1 - 6.1 5.9 16.8 8.1 5.5 16.8 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Methyltransf_23 PF13489.6 EXF85550.1 - 6.6e-20 71.6 0.0 1.1e-19 70.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF85550.1 - 8e-13 48.9 0.0 2e-12 47.6 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF85550.1 - 3e-11 43.8 0.0 7.8e-11 42.5 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF85550.1 - 6.4e-10 39.7 0.0 3.9e-09 37.1 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF85550.1 - 2.5e-08 33.9 0.0 1.3e-07 31.5 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.18 EXF85550.1 - 0.00017 21.0 0.0 0.00034 20.0 0.0 1.5 1 1 0 1 1 1 1 O-methyltransferase domain Ubie_methyltran PF01209.18 EXF85550.1 - 0.00026 20.4 0.0 0.0028 17.0 0.0 2.3 2 1 0 2 2 2 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 EXF85550.1 - 0.0036 16.9 0.0 0.019 14.5 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase small domain FtsJ PF01728.19 EXF85550.1 - 0.0046 17.1 0.1 0.025 14.7 0.0 2.0 2 1 0 2 2 2 1 FtsJ-like methyltransferase Methyltransf_4 PF02390.17 EXF85550.1 - 0.014 14.9 0.0 0.075 12.5 0.0 2.0 2 0 0 2 2 2 0 Putative methyltransferase CMAS PF02353.20 EXF85550.1 - 0.028 13.7 0.0 0.044 13.1 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase PrmA PF06325.13 EXF85550.1 - 0.15 11.5 0.0 0.29 10.5 0.0 1.5 1 1 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) F-box-like PF12937.7 EXF85551.1 - 0.029 14.2 0.0 0.099 12.6 0.0 2.0 1 0 0 1 1 1 0 F-box-like FMO-like PF00743.19 EXF85552.1 - 1.5e-24 86.4 0.0 6.6e-20 71.0 0.0 2.1 2 0 0 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EXF85552.1 - 9e-14 51.4 0.0 2.1e-11 43.6 0.0 2.3 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EXF85552.1 - 1.5e-12 47.3 0.0 2.8e-12 46.5 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EXF85552.1 - 5.1e-10 39.0 0.0 4.4e-08 32.7 0.0 2.8 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 EXF85552.1 - 5.7e-07 29.7 0.0 2.1e-05 24.7 0.0 2.7 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 EXF85552.1 - 1.2e-06 28.6 0.8 0.046 13.7 0.0 2.6 2 1 1 3 3 3 2 FAD-NAD(P)-binding DAO PF01266.24 EXF85552.1 - 2.1e-06 27.6 0.5 0.00072 19.2 0.0 2.8 3 0 0 3 3 3 2 FAD dependent oxidoreductase Amino_oxidase PF01593.24 EXF85552.1 - 0.001 18.5 0.0 1.3 8.2 0.0 2.6 3 0 0 3 3 3 2 Flavin containing amine oxidoreductase FAD_binding_3 PF01494.19 EXF85552.1 - 0.004 16.5 0.5 0.063 12.5 0.0 2.1 2 0 0 2 2 2 1 FAD binding domain Thi4 PF01946.17 EXF85552.1 - 0.036 13.3 0.0 0.25 10.6 0.0 2.0 2 0 0 2 2 2 0 Thi4 family 2-Hacid_dh_C PF02826.19 EXF85552.1 - 0.056 12.8 0.0 0.83 9.0 0.0 2.1 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DUF498 PF04430.14 EXF85552.1 - 0.14 12.2 0.0 4.8 7.3 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF498/DUF598) DUF2235 PF09994.9 EXF85553.1 - 2.3e-43 148.6 0.0 2.9e-43 148.3 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) Helo_like_N PF17111.5 EXF85554.1 - 2.3e-12 46.7 0.2 3.2e-12 46.3 0.2 1.2 1 0 0 1 1 1 1 Fungal N-terminal domain of STAND proteins RhgB_N PF09284.10 EXF85555.1 - 2.6e-92 308.9 0.0 3.9e-92 308.3 0.0 1.3 1 0 0 1 1 1 1 Rhamnogalacturonan lyase B, N-terminal CBM-like PF14683.6 EXF85555.1 - 5.3e-32 111.0 0.0 9.5e-32 110.2 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide lyase family 4, domain III fn3_3 PF14686.6 EXF85555.1 - 8.1e-18 64.0 1.1 7.8e-17 60.8 0.4 2.8 3 0 0 3 3 3 1 Polysaccharide lyase family 4, domain II DPM3 PF08285.11 EXF85556.1 - 1.2e-35 121.6 0.2 1.3e-35 121.5 0.2 1.0 1 0 0 1 1 1 1 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) Abhydrolase_3 PF07859.13 EXF85557.1 - 2.1e-62 210.7 0.0 2.7e-62 210.4 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EXF85557.1 - 2.1e-07 30.6 0.0 3.2e-07 30.0 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family COesterase PF00135.28 EXF85557.1 - 4.4e-05 22.6 0.0 0.00045 19.2 0.0 1.9 2 0 0 2 2 2 1 Carboxylesterase family Ribonuc_L-PSP PF01042.21 EXF85558.1 - 3.1e-37 127.3 0.0 3.4e-37 127.1 0.0 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP DUF2529 PF10740.9 EXF85558.1 - 0.13 11.9 0.0 0.16 11.6 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2529) Pirin PF02678.16 EXF85558.1 - 0.15 12.1 0.0 0.18 11.8 0.0 1.2 1 0 0 1 1 1 0 Pirin MFS_1 PF07690.16 EXF85559.1 - 3.8e-33 114.9 29.9 4.2e-33 114.7 26.9 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily BT1 PF03092.16 EXF85559.1 - 0.021 13.1 4.7 0.01 14.1 0.9 2.0 2 0 0 2 2 2 0 BT1 family HET PF06985.11 EXF85560.1 - 3.1e-17 63.3 0.0 6.5e-17 62.2 0.0 1.6 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Trp_DMAT PF11991.8 EXF85561.1 - 1.7e-65 221.8 0.0 2.2e-65 221.4 0.0 1.1 1 0 0 1 1 1 1 Tryptophan dimethylallyltransferase Terpene_synth_C PF03936.16 EXF85564.1 - 1.5e-05 24.5 0.4 8.9e-05 22.0 0.4 1.9 1 1 0 1 1 1 1 Terpene synthase family, metal binding domain NAD_Gly3P_dh_N PF01210.23 EXF85564.1 - 0.15 12.1 0.0 0.24 11.4 0.0 1.3 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus FAD_binding_4 PF01565.23 EXF85565.1 - 1.4e-08 34.5 0.6 2.2e-05 24.2 0.0 2.6 2 0 0 2 2 2 2 FAD binding domain FAD-oxidase_C PF02913.19 EXF85565.1 - 4.3e-08 33.1 0.0 6.3e-08 32.6 0.0 1.2 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain ABM PF03992.16 EXF85566.1 - 0.008 16.3 0.4 0.73 10.0 0.5 2.3 2 0 0 2 2 2 2 Antibiotic biosynthesis monooxygenase 4HBT_3 PF13622.6 EXF85567.1 - 1.1e-80 271.5 0.5 1.3e-80 271.2 0.5 1.1 1 0 0 1 1 1 1 Thioesterase-like superfamily Acyl_CoA_thio PF02551.15 EXF85567.1 - 2.6e-25 88.8 0.0 2.4e-10 40.4 0.0 4.1 3 1 0 3 3 3 3 Acyl-CoA thioesterase Ge1_WD40 PF16529.5 EXF85567.1 - 0.25 10.2 0.0 0.33 9.9 0.0 1.2 1 0 0 1 1 1 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Oxysterol_BP PF01237.18 EXF85568.1 - 2.5e-134 447.8 0.0 2.5e-134 447.8 0.0 2.7 3 0 0 3 3 3 1 Oxysterol-binding protein Ank PF00023.30 EXF85568.1 - 1e-14 54.2 0.3 5.8e-05 23.4 0.0 3.7 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.6 EXF85568.1 - 3.5e-14 52.7 0.1 5.9e-07 29.7 0.0 3.5 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 EXF85568.1 - 5.4e-14 52.5 0.1 1.6e-09 38.2 0.0 2.7 1 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EXF85568.1 - 7.6e-12 45.5 0.0 9e-07 29.3 0.0 3.0 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EXF85568.1 - 2.5e-11 42.8 0.0 0.0015 18.9 0.0 3.8 3 0 0 3 3 3 2 Ankyrin repeat PH PF00169.29 EXF85568.1 - 2.6e-11 44.0 0.8 5.8e-11 42.8 0.8 1.7 1 0 0 1 1 1 1 PH domain PH_8 PF15409.6 EXF85568.1 - 1.4e-07 31.7 1.0 3.9e-07 30.3 1.0 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 EXF85568.1 - 2.5e-05 24.6 2.3 7e-05 23.2 2.3 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain Hypoth_Ymh PF09509.10 EXF85568.1 - 0.19 11.6 2.2 2.3 8.2 0.5 3.0 4 0 0 4 4 4 0 Protein of unknown function (Hypoth_ymh) Glyco_hydro_18 PF00704.28 EXF85569.1 - 3.8e-14 53.1 1.4 9.4e-14 51.8 1.4 1.7 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 SLC35F PF06027.12 EXF85571.1 - 2.8e-97 325.8 23.2 3.8e-97 325.4 23.2 1.1 1 0 0 1 1 1 1 Solute carrier family 35 CRT-like PF08627.10 EXF85571.1 - 4.7e-10 38.9 6.1 7.3e-10 38.3 6.1 1.3 1 0 0 1 1 1 1 CRT-like, chloroquine-resistance transporter-like EamA PF00892.20 EXF85571.1 - 9.5e-08 32.3 37.5 0.00034 20.8 11.2 2.2 2 0 0 2 2 2 2 EamA-like transporter family FUSC-like PF12805.7 EXF85571.1 - 0.42 9.7 7.6 0.066 12.3 1.9 2.3 2 1 0 2 2 2 0 FUSC-like inner membrane protein yccS DUF2189 PF09955.9 EXF85572.1 - 0.02 15.1 1.3 0.2 11.9 0.0 2.7 3 0 0 3 3 3 0 Predicted integral membrane protein (DUF2189) CFEM PF05730.11 EXF85573.1 - 6.5e-10 39.0 13.8 1.6e-09 37.7 13.8 1.7 1 0 0 1 1 1 1 CFEM domain Macoilin PF09726.9 EXF85573.1 - 3.5 6.1 5.4 4.3 5.8 5.4 1.1 1 0 0 1 1 1 0 Macoilin family DUF3883 PF13020.6 EXF85574.1 - 0.0026 17.8 0.0 0.0052 16.8 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3883) HATPase_c_3 PF13589.6 EXF85575.1 - 0.066 13.0 0.4 0.24 11.2 0.4 1.9 1 1 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PI3Ka PF00613.20 EXF85577.1 - 1.5e-59 200.5 1.4 2.4e-59 199.9 1.4 1.3 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.27 EXF85577.1 - 5.6e-46 157.4 0.0 8.3e-43 147.0 0.1 2.7 2 1 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase PI3K_C2 PF00792.24 EXF85577.1 - 3.2e-32 111.3 0.0 7.6e-32 110.1 0.0 1.7 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 Nse4_C PF08743.10 EXF85578.1 - 2e-34 117.7 0.1 4.4e-34 116.6 0.1 1.6 1 0 0 1 1 1 1 Nse4 C-terminal Nse4-Nse3_bdg PF15412.6 EXF85578.1 - 5e-17 61.7 0.0 5e-17 61.7 0.0 2.2 2 0 0 2 2 2 1 Binding domain of Nse4/EID3 to Nse3-MAGE PBP1_TM PF14812.6 EXF85578.1 - 1.2 9.5 11.7 31 5.0 8.7 2.7 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF4336 PF14234.6 EXF85579.1 - 2.1e-13 50.2 0.3 2e-08 33.8 0.0 2.6 2 1 0 2 2 2 2 Domain of unknown function (DUF4336) BTB PF00651.31 EXF85580.1 - 1.8e-12 47.4 0.1 3.6e-12 46.5 0.0 1.5 2 0 0 2 2 2 1 BTB/POZ domain CNH PF00780.22 EXF85581.1 - 1.1e-79 268.0 0.0 4e-79 266.1 0.0 1.8 2 0 0 2 2 2 1 CNH domain PH_5 PF15405.6 EXF85581.1 - 6.9e-45 152.5 0.0 1.5e-44 151.4 0.0 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain RhoGEF PF00621.20 EXF85581.1 - 1.2e-35 123.4 0.0 2.4e-35 122.4 0.0 1.5 1 0 0 1 1 1 1 RhoGEF domain DEP PF00610.21 EXF85581.1 - 5.5e-15 55.2 0.0 1.2e-14 54.1 0.0 1.6 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) ATP-synt_C PF00137.21 EXF85582.1 - 2.3e-20 72.7 38.9 4.2e-18 65.4 10.0 3.1 2 1 0 2 2 2 2 ATP synthase subunit C Herpes_UL32 PF06070.11 EXF85583.1 - 0.28 8.9 4.7 0.067 10.9 1.7 1.4 2 0 0 2 2 2 0 Herpesvirus large structural phosphoprotein UL32 MFS_1 PF07690.16 EXF85584.1 - 2.2e-34 119.0 54.1 1.6e-29 103.0 46.4 2.6 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 EXF85584.1 - 0.001 18.0 14.9 0.001 18.0 14.9 2.4 2 1 0 2 2 2 1 MFS_1 like family DUF3272 PF11676.8 EXF85584.1 - 0.0085 16.3 1.1 0.066 13.5 0.3 2.7 2 0 0 2 2 2 1 Protein of unknown function (DUF3272) DUF3043 PF11241.8 EXF85584.1 - 1.6 8.7 3.2 2.4 8.2 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3043) PI3_PI4_kinase PF00454.27 EXF85585.1 - 4.9e-52 177.2 0.0 1.2e-51 176.0 0.0 1.7 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase UME PF08064.13 EXF85585.1 - 2.3e-33 114.2 0.6 1e-32 112.1 0.0 2.6 2 0 0 2 2 2 1 UME (NUC010) domain FAT PF02259.23 EXF85585.1 - 2.9e-30 105.7 3.3 4.6e-30 105.0 3.3 1.3 1 0 0 1 1 1 1 FAT domain FATC PF02260.20 EXF85585.1 - 3.9e-17 61.7 0.5 2e-15 56.3 0.0 2.6 2 0 0 2 2 2 1 FATC domain TPR_19 PF14559.6 EXF85585.1 - 0.00027 21.4 1.9 0.035 14.6 0.0 4.1 3 0 0 3 3 3 1 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.6 EXF85585.1 - 0.77 10.2 2.3 2.5 8.6 0.7 2.5 2 0 0 2 2 2 0 Alkyl sulfatase dimerisation zf-PARP PF00645.18 EXF85586.1 - 2.8e-19 69.8 1.1 9.5e-19 68.1 1.1 2.0 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region DUF4734 PF15881.5 EXF85587.1 - 0.29 11.3 2.3 0.62 10.3 2.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4734) SKG6 PF08693.10 EXF85588.1 - 0.032 13.6 1.6 0.1 12.0 1.6 1.9 1 0 0 1 1 1 0 Transmembrane alpha-helix domain PFK PF00365.20 EXF85589.1 - 2e-188 624.5 0.3 1.6e-105 352.5 1.0 2.1 2 0 0 2 2 2 2 Phosphofructokinase UVR PF02151.19 EXF85589.1 - 0.073 12.8 0.2 0.17 11.7 0.2 1.6 1 0 0 1 1 1 0 UvrB/uvrC motif TgMIC1 PF11476.8 EXF85589.1 - 0.083 12.6 0.8 5.4 6.8 0.0 2.4 2 0 0 2 2 2 0 Toxoplasma gondii micronemal protein 1 TgMIC1 DUF211 PF02680.14 EXF85589.1 - 0.11 12.7 0.0 0.26 11.5 0.0 1.6 1 0 0 1 1 1 0 Uncharacterized ArCR, COG1888 His_Phos_2 PF00328.22 EXF85591.1 - 2.1e-112 376.3 0.1 8.4e-111 371.0 0.1 2.2 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) PPIP5K2_N PF18086.1 EXF85591.1 - 2.6e-36 123.6 0.1 5e-36 122.7 0.1 1.4 1 0 0 1 1 1 1 Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain RimK PF08443.11 EXF85591.1 - 9.1e-06 25.4 0.0 1.6e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 RimK-like ATP-grasp domain Utp21 PF04192.12 EXF85592.1 - 1.4e-82 276.7 0.0 2.1e-82 276.1 0.0 1.2 1 0 0 1 1 1 1 Utp21 specific WD40 associated putative domain WD40 PF00400.32 EXF85592.1 - 6.5e-16 58.4 21.8 4.7e-06 27.2 0.8 9.0 9 0 0 9 9 9 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EXF85592.1 - 1.3e-13 51.0 0.0 0.00063 20.0 0.0 6.3 2 2 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EXF85592.1 - 0.00021 20.1 0.9 3.6 6.1 0.0 3.6 3 1 0 3 3 3 3 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 EXF85592.1 - 0.00048 18.8 0.0 0.00084 18.0 0.0 1.3 1 0 0 1 1 1 1 Cytochrome D1 heme domain PALB2_WD40 PF16756.5 EXF85592.1 - 0.011 14.6 0.0 0.63 8.9 0.0 2.7 3 0 0 3 3 3 0 Partner and localizer of BRCA2 WD40 domain Nucleoporin_N PF08801.11 EXF85592.1 - 0.06 12.1 0.0 2.7 6.7 0.0 2.3 1 1 0 2 2 2 0 Nup133 N terminal like HPS3_N PF14761.6 EXF85592.1 - 0.1 12.1 0.0 0.44 10.1 0.0 2.0 3 0 0 3 3 3 0 Hermansky-Pudlak syndrome 3 MMS1_N PF10433.9 EXF85592.1 - 0.19 10.3 0.0 0.33 9.5 0.0 1.3 1 0 0 1 1 1 0 Mono-functional DNA-alkylating methyl methanesulfonate N-term Peptidase_S78_2 PF14550.6 EXF85592.1 - 0.5 10.5 1.4 0.55 10.3 0.1 1.8 2 0 0 2 2 2 0 Putative phage serine protease XkdF Pkinase PF00069.25 EXF85593.1 - 3.7e-53 180.6 0.0 5.2e-53 180.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF85593.1 - 1.9e-20 73.2 0.0 3.6e-20 72.3 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EXF85593.1 - 0.057 13.3 0.0 0.15 12.0 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family Vmethyltransf_C PF08456.10 EXF85593.1 - 0.21 11.1 0.2 0.38 10.3 0.2 1.3 1 0 0 1 1 1 0 Viral methyltransferase C-terminal RIO1 PF01163.22 EXF85593.1 - 0.26 10.9 0.6 0.52 9.9 0.1 1.8 2 0 0 2 2 2 0 RIO1 family Choline_kinase PF01633.20 EXF85593.1 - 0.86 9.1 4.2 0.17 11.4 0.5 1.7 2 0 0 2 2 2 0 Choline/ethanolamine kinase Pex24p PF06398.11 EXF85594.1 - 1.3e-88 297.5 0.0 1.6e-88 297.1 0.0 1.1 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin DUF3292 PF11696.8 EXF85594.1 - 0.033 12.6 1.7 0.04 12.3 0.7 1.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3292) Reticulon PF02453.17 EXF85594.1 - 0.076 13.0 3.2 0.31 11.0 3.2 1.9 1 1 1 2 2 2 0 Reticulon DUF4395 PF14340.6 EXF85594.1 - 1.1 9.6 7.6 5.5 7.3 0.1 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4395) polyprenyl_synt PF00348.17 EXF85595.1 - 3.6e-66 222.8 0.0 4.5e-66 222.5 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase CDC14 PF08045.11 EXF85596.1 - 1.5e-131 437.7 0.0 1.7e-131 437.6 0.0 1.0 1 0 0 1 1 1 1 Cell division control protein 14, SIN component SKG6 PF08693.10 EXF85597.1 - 0.023 14.1 2.0 0.053 12.9 2.0 1.6 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Kdo PF06293.14 EXF85598.1 - 6.8e-09 35.4 0.0 1.3e-06 28.0 0.0 2.2 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EXF85598.1 - 1.8e-08 34.6 6.1 7e-05 22.9 0.4 2.7 1 1 1 2 2 2 2 Phosphotransferase enzyme family Pkinase PF00069.25 EXF85598.1 - 7e-07 28.9 0.0 1.1e-06 28.2 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 EXF85598.1 - 0.0058 15.5 0.0 0.0082 15.0 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Pkinase_Tyr PF07714.17 EXF85598.1 - 0.027 13.8 0.0 0.033 13.5 0.0 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase RIO1 PF01163.22 EXF85598.1 - 0.068 12.8 0.0 1.4 8.4 0.0 2.4 2 0 0 2 2 2 0 RIO1 family Choline_kinase PF01633.20 EXF85598.1 - 0.23 11.0 0.0 0.28 10.7 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase Acyl_transf_3 PF01757.22 EXF85599.1 - 6.2e-45 153.7 34.4 7.8e-45 153.4 34.4 1.1 1 0 0 1 1 1 1 Acyltransferase family ALAD PF00490.21 EXF85600.1 - 3.5e-120 400.9 0.0 4.2e-120 400.7 0.0 1.1 1 0 0 1 1 1 1 Delta-aminolevulinic acid dehydratase DNA_pol_viral_N PF00242.17 EXF85602.1 - 0.077 12.5 3.0 0.094 12.2 3.0 1.0 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain Mito_carr PF00153.27 EXF85603.1 - 1.5e-50 169.0 1.2 1.9e-18 66.2 0.2 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 EXF85603.1 - 0.093 11.9 0.2 0.27 10.3 0.1 1.9 2 0 0 2 2 2 0 Gammaproteobacterial serine protease RNA_pol_A_bac PF01000.26 EXF85604.1 - 2.1e-33 115.0 0.0 3.4e-33 114.4 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 EXF85604.1 - 3.2e-18 64.9 0.0 4.4e-18 64.5 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain PriA_CRR PF18319.1 EXF85604.1 - 0.053 13.5 1.7 0.15 12.1 1.7 1.8 1 0 0 1 1 1 0 PriA DNA helicase Cys-rich region (CRR) domain GrpE PF01025.19 EXF85605.1 - 2.1e-49 167.4 5.7 2.7e-49 167.0 5.7 1.1 1 0 0 1 1 1 1 GrpE DUF334 PF03904.13 EXF85605.1 - 0.032 13.8 0.2 0.048 13.2 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF334) IL2 PF00715.17 EXF85605.1 - 0.13 12.1 0.2 0.21 11.5 0.2 1.3 1 0 0 1 1 1 0 Interleukin 2 GPS2_interact PF15784.5 EXF85605.1 - 3.5 8.1 7.7 0.18 12.2 1.1 2.2 2 0 0 2 2 2 0 G-protein pathway suppressor 2-interacting domain APG6_N PF17675.1 EXF85605.1 - 3.8 8.0 11.1 1.5 9.3 7.7 1.8 1 1 1 2 2 2 0 Apg6 coiled-coil region RFC1 PF08519.12 EXF85607.1 - 1.9e-57 193.8 0.0 4.8e-57 192.5 0.0 1.7 1 0 0 1 1 1 1 Replication factor RFC1 C terminal domain BRCT PF00533.26 EXF85607.1 - 8.1e-15 55.0 0.0 1.9e-14 53.8 0.0 1.7 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain AAA PF00004.29 EXF85607.1 - 1.1e-08 35.6 0.1 6.5e-08 33.1 0.1 2.2 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 EXF85607.1 - 1.5e-06 28.3 0.0 3.6e-06 27.0 0.0 1.6 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_18 PF13238.6 EXF85607.1 - 0.0015 19.1 0.1 0.008 16.7 0.1 2.4 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EXF85607.1 - 0.0029 17.9 0.0 0.014 15.7 0.0 2.2 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EXF85607.1 - 0.0058 17.0 0.1 0.036 14.5 0.1 2.2 1 1 0 2 2 2 1 AAA ATPase domain AAA_28 PF13521.6 EXF85607.1 - 0.011 16.0 0.3 0.17 12.1 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.6 EXF85607.1 - 0.034 14.2 0.1 0.13 12.3 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 EXF85607.1 - 0.052 13.7 0.0 0.2 11.8 0.0 2.0 1 0 0 1 1 1 0 AAA domain RuvB_N PF05496.12 EXF85607.1 - 0.09 12.5 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain DNA_pol3_delta PF06144.13 EXF85607.1 - 0.1 12.4 0.0 0.23 11.2 0.0 1.6 1 0 0 1 1 1 0 DNA polymerase III, delta subunit NTPase_1 PF03266.15 EXF85607.1 - 0.12 12.3 0.0 0.29 11.0 0.0 1.6 1 0 0 1 1 1 0 NTPase PTCB-BRCT PF12738.7 EXF85607.1 - 0.12 12.3 0.0 0.32 11.0 0.0 1.8 1 0 0 1 1 1 0 twin BRCT domain AAA_17 PF13207.6 EXF85607.1 - 2.1 8.8 0.0 2.1 8.8 0.0 3.7 4 0 0 4 4 4 0 AAA domain Ribosomal_L16 PF00252.18 EXF85608.1 - 3.7e-33 114.3 0.6 5.2e-33 113.9 0.6 1.2 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e DNA_pol3_delta2 PF13177.6 EXF85609.1 - 1.3e-10 41.3 0.0 2.8e-10 40.2 0.0 1.6 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA_22 PF13401.6 EXF85609.1 - 8.7e-07 29.3 0.1 1.9e-05 24.9 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 EXF85609.1 - 1.6e-06 28.6 0.1 3.8e-06 27.4 0.1 1.6 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EXF85609.1 - 0.00031 21.2 1.2 0.01 16.2 0.4 2.9 2 1 0 2 2 2 1 AAA ATPase domain Rep_fac_C PF08542.11 EXF85609.1 - 0.00065 20.1 0.0 0.002 18.5 0.0 1.8 1 0 0 1 1 1 1 Replication factor C C-terminal domain AAA_24 PF13479.6 EXF85609.1 - 0.00068 19.4 0.3 0.002 17.9 0.3 1.7 1 1 0 1 1 1 1 AAA domain ABC_tran PF00005.27 EXF85609.1 - 0.014 15.9 0.0 0.029 14.9 0.0 1.6 1 0 0 1 1 1 0 ABC transporter T4SS-DNA_transf PF02534.14 EXF85609.1 - 0.029 13.2 0.1 0.13 11.0 0.0 1.9 2 0 0 2 2 2 0 Type IV secretory system Conjugative DNA transfer Rad17 PF03215.15 EXF85609.1 - 0.034 14.1 0.0 0.059 13.3 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_5 PF07728.14 EXF85609.1 - 0.18 11.8 0.5 0.59 10.1 0.4 1.8 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_29 PF13555.6 EXF85609.1 - 0.21 11.4 0.1 4.6 7.1 0.0 2.6 2 0 0 2 2 2 0 P-loop containing region of AAA domain AMP-binding PF00501.28 EXF85610.1 - 2.4e-85 286.7 0.1 2.9e-85 286.4 0.1 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EXF85610.1 - 1.5e-26 93.2 0.7 3.2e-25 88.9 0.5 2.5 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain ACAS_N PF16177.5 EXF85610.1 - 1.5e-19 69.6 0.4 4.8e-19 68.0 0.4 1.9 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus Reprolysin_5 PF13688.6 EXF85611.1 - 1.2e-61 208.3 9.2 1.2e-61 208.3 9.2 3.0 2 1 1 3 3 3 1 Metallo-peptidase family M12 Reprolysin_2 PF13574.6 EXF85611.1 - 2.1e-53 181.1 3.9 2.1e-53 181.1 3.9 2.2 3 0 0 3 3 3 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 EXF85611.1 - 3.6e-49 167.2 5.0 6.5e-49 166.3 5.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Disintegrin PF00200.23 EXF85611.1 - 3.9e-17 62.8 33.0 3.9e-17 62.8 33.0 4.7 3 1 1 4 4 4 1 Disintegrin Reprolysin_3 PF13582.6 EXF85611.1 - 2.3e-13 50.8 0.1 5.8e-13 49.4 0.1 1.8 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin PF01421.19 EXF85611.1 - 8.6e-05 22.5 8.4 8.6e-05 22.5 8.4 3.3 2 1 0 2 2 2 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR_2 PF17771.1 EXF85611.1 - 0.0007 20.1 14.3 0.0007 20.1 14.3 5.3 2 1 2 4 4 4 1 ADAM cysteine-rich domain Pep_M12B_propep PF01562.19 EXF85611.1 - 0.012 15.9 0.2 0.024 14.9 0.2 1.4 1 0 0 1 1 1 0 Reprolysin family propeptide DUF4953 PF16313.5 EXF85611.1 - 0.24 10.6 0.0 0.4 9.8 0.0 1.3 1 0 0 1 1 1 0 Met-zincin TLD PF07534.16 EXF85613.1 - 2.9e-24 85.9 0.0 7.8e-13 48.8 0.0 2.2 2 0 0 2 2 2 2 TLD Pkinase PF00069.25 EXF85614.1 - 5.7e-68 229.1 0.0 7.5e-68 228.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF85614.1 - 5.8e-32 111.0 0.0 7.6e-32 110.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EXF85614.1 - 0.00034 20.0 0.3 0.00056 19.3 0.3 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EXF85614.1 - 0.0011 18.0 0.2 0.0018 17.3 0.2 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 EXF85614.1 - 0.0078 15.6 0.0 0.013 14.8 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EXF85614.1 - 0.026 14.5 0.0 0.039 13.9 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 EXF85614.1 - 0.058 12.4 0.0 0.089 11.8 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Gag_p6 PF08705.11 EXF85614.1 - 0.1 12.9 0.1 0.2 11.9 0.1 1.4 1 0 0 1 1 1 0 Gag protein p6 S_100 PF01023.19 EXF85614.1 - 0.13 12.0 0.2 0.38 10.5 0.2 1.8 1 0 0 1 1 1 0 S-100/ICaBP type calcium binding domain Sec23_trunk PF04811.15 EXF85615.1 - 1.1e-70 238.0 0.0 1.6e-70 237.5 0.0 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 EXF85615.1 - 5.2e-26 90.5 0.1 3.3e-25 87.9 0.0 2.3 2 1 0 2 2 2 1 Sec23/Sec24 helical domain Sec23_BS PF08033.12 EXF85615.1 - 8.7e-18 64.9 0.0 2e-17 63.7 0.0 1.7 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 EXF85615.1 - 9.2e-17 60.8 4.7 1.6e-16 60.1 4.7 1.4 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 EXF85615.1 - 1.6e-10 40.7 0.0 4.2e-10 39.4 0.0 1.8 1 0 0 1 1 1 1 Gelsolin repeat Vps36-NZF-N PF16988.5 EXF85615.1 - 0.036 13.4 0.1 0.081 12.3 0.1 1.5 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain Fungal_trans_2 PF11951.8 EXF85617.1 - 2.3e-10 39.9 0.4 4.5e-10 38.9 0.4 1.5 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF85617.1 - 1.4e-06 28.3 12.3 2.9e-06 27.3 12.3 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Herpes_UL25 PF01499.16 EXF85617.1 - 0.057 11.9 0.0 0.093 11.2 0.0 1.3 1 0 0 1 1 1 0 Herpesvirus UL25 family Xpo1 PF08389.12 EXF85618.1 - 9.2e-09 35.5 0.9 0.00085 19.4 0.0 4.2 3 0 0 3 3 3 2 Exportin 1-like protein IBN_N PF03810.19 EXF85618.1 - 2.8e-05 23.9 0.4 0.00035 20.4 0.1 3.1 2 0 0 2 2 2 1 Importin-beta N-terminal domain APC1_C PF18122.1 EXF85618.1 - 0.028 14.3 1.4 0.16 11.9 0.1 2.8 3 1 0 3 3 3 0 Anaphase-promoting complex sub unit 1 C-terminal domain WD40 PF00400.32 EXF85619.1 - 2.3e-05 25.0 0.4 0.017 16.0 0.0 4.7 5 0 0 5 5 5 1 WD domain, G-beta repeat DUF1917 PF08939.10 EXF85620.1 - 6.7e-83 278.6 0.2 7.6e-83 278.4 0.2 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1917) Mhr1 PF12829.7 EXF85620.1 - 0.14 12.3 0.0 0.27 11.3 0.0 1.5 1 0 0 1 1 1 0 Transcriptional regulation of mitochondrial recombination Acetyltransf_1 PF00583.25 EXF85621.1 - 2.3e-20 73.0 0.0 2.9e-20 72.6 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EXF85621.1 - 1.5e-11 44.3 0.0 2.2e-11 43.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EXF85621.1 - 1.8e-10 41.1 0.0 2.5e-10 40.6 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EXF85621.1 - 1.3e-09 37.9 0.0 2.1e-09 37.2 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_3 PF13302.7 EXF85621.1 - 6.8e-08 33.3 0.0 8.3e-08 33.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EXF85621.1 - 6.7e-07 29.4 0.0 1.2e-06 28.6 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 EXF85621.1 - 1.3e-06 28.1 0.0 1.7e-06 27.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EXF85621.1 - 0.0011 19.0 0.0 0.002 18.2 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_18 PF18014.1 EXF85621.1 - 0.032 14.1 0.0 0.047 13.5 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 EXF85621.1 - 0.076 12.5 0.0 0.092 12.2 0.0 1.3 1 0 0 1 1 1 0 Putative acetyl-transferase GNAT_acetyltran PF12746.7 EXF85621.1 - 0.086 12.4 0.0 0.12 12.0 0.0 1.2 1 0 0 1 1 1 0 GNAT acetyltransferase LCAT PF02450.15 EXF85622.1 - 7.1e-109 364.5 0.1 9.2e-109 364.2 0.1 1.1 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase Abhydrolase_6 PF12697.7 EXF85622.1 - 0.0049 17.5 0.4 0.016 15.8 0.1 1.8 1 1 1 2 2 2 1 Alpha/beta hydrolase family DUF1778 PF08681.11 EXF85622.1 - 0.1 12.5 0.0 0.24 11.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1778) DUF2013 PF09431.10 EXF85623.1 - 5.7e-52 175.6 1.6 5.7e-52 175.6 1.6 1.9 2 1 0 2 2 2 1 Protein of unknown function (DUF2013) IBN_N PF03810.19 EXF85623.1 - 0.0081 16.1 0.3 0.16 11.9 0.1 2.5 2 0 0 2 2 2 1 Importin-beta N-terminal domain PH PF00169.29 EXF85624.1 - 7.2e-05 23.2 0.1 0.00019 21.9 0.1 1.7 1 0 0 1 1 1 1 PH domain WEMBL PF05701.11 EXF85624.1 - 0.15 10.7 1.7 0.25 10.0 1.7 1.2 1 0 0 1 1 1 0 Weak chloroplast movement under blue light Prominin PF05478.11 EXF85624.1 - 0.31 8.9 0.1 0.45 8.4 0.1 1.1 1 0 0 1 1 1 0 Prominin MFS_1 PF07690.16 EXF85625.1 - 1.3e-29 103.3 47.8 6e-29 101.1 47.8 2.0 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF4191 PF13829.6 EXF85625.1 - 1.4 8.2 2.6 5.3 6.3 1.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4191) Gar1 PF04410.14 EXF85626.1 - 7.8e-35 119.9 0.1 1.1e-34 119.4 0.1 1.1 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region tRNA-synt_2b PF00587.25 EXF85627.1 - 6.4e-31 107.7 0.0 4.5e-29 101.7 0.0 2.3 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 EXF85627.1 - 3.6e-21 75.1 0.3 7e-21 74.2 0.3 1.5 1 0 0 1 1 1 1 Anticodon binding domain TGS PF02824.21 EXF85627.1 - 4.4e-11 42.6 0.0 1e-10 41.5 0.0 1.7 1 0 0 1 1 1 1 TGS domain tRNA_SAD PF07973.14 EXF85627.1 - 6.4e-11 42.2 0.0 1.6e-10 40.9 0.0 1.7 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain PepSY_like PF11396.8 EXF85627.1 - 0.03 14.9 0.5 0.4 11.3 0.1 2.8 3 0 0 3 3 3 0 Putative beta-lactamase-inhibitor-like, PepSY-like CDP-OH_P_transf PF01066.21 EXF85628.1 - 1.6e-13 51.2 0.4 4.3e-13 49.8 0.4 1.8 1 0 0 1 1 1 1 CDP-alcohol phosphatidyltransferase Metallopep PF12044.8 EXF85629.1 - 5.2e-170 565.7 0.0 6.6e-170 565.3 0.0 1.1 1 0 0 1 1 1 1 Putative peptidase family Jacalin PF01419.17 EXF85629.1 - 5.9e-05 23.0 0.0 0.00011 22.1 0.0 1.4 1 0 0 1 1 1 1 Jacalin-like lectin domain Reprolysin_5 PF13688.6 EXF85629.1 - 0.0059 16.8 0.1 0.012 15.7 0.1 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12 Whi5 PF08528.11 EXF85630.1 - 1.2e-10 40.7 0.2 2.2e-10 39.9 0.2 1.4 1 0 0 1 1 1 1 Whi5 like HEM4 PF02602.15 EXF85631.1 - 2.7e-42 144.7 0.0 3.6e-42 144.3 0.0 1.1 1 0 0 1 1 1 1 Uroporphyrinogen-III synthase HemD Evr1_Alr PF04777.13 EXF85632.1 - 4.1e-32 110.6 0.4 2.1e-31 108.4 0.4 1.8 2 0 0 2 2 2 1 Erv1 / Alr family DDE_Tnp_ISL3 PF01610.17 EXF85632.1 - 0.18 11.5 0.0 0.23 11.1 0.0 1.1 1 0 0 1 1 1 0 Transposase CotE PF10628.9 EXF85632.1 - 0.19 11.4 0.0 0.26 10.9 0.0 1.1 1 0 0 1 1 1 0 Outer spore coat protein E (CotE) TPP_enzyme_N PF02776.18 EXF85633.1 - 1.3e-33 116.0 0.0 2.4e-33 115.2 0.0 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 EXF85633.1 - 1.5e-22 79.8 0.0 3.1e-22 78.8 0.0 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 EXF85633.1 - 6.5e-16 58.5 0.1 4.8e-15 55.7 0.1 2.3 2 1 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain DXP_synthase_N PF13292.6 EXF85633.1 - 0.0036 16.5 0.0 0.0058 15.9 0.0 1.2 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase E1_dh PF00676.20 EXF85633.1 - 0.012 14.6 0.0 0.02 13.8 0.0 1.3 1 0 0 1 1 1 0 Dehydrogenase E1 component OCC1 PF15506.6 EXF85633.1 - 0.062 13.4 2.1 8.3 6.6 0.1 3.0 3 0 0 3 3 3 0 OCC1 family THUMP PF02926.17 EXF85634.1 - 2e-06 28.0 0.6 1.7e-05 25.0 0.2 2.5 1 1 1 2 2 2 1 THUMP domain SGT1 PF07093.11 EXF85636.1 - 3.2e-98 329.7 20.0 2.6e-89 300.3 0.0 2.0 1 1 0 2 2 2 2 SGT1 protein DUF5075 PF16825.5 EXF85636.1 - 0.034 13.9 0.0 0.071 12.8 0.0 1.5 1 0 0 1 1 1 0 IGP family C-type lectin domain Lin-8 PF03353.15 EXF85636.1 - 0.51 9.8 5.0 0.95 9.0 5.0 1.4 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist SMC_N PF02463.19 EXF85637.1 - 3.7e-23 82.1 0.2 1.6e-22 80.1 0.2 2.0 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EXF85637.1 - 8.9e-18 65.5 0.1 8.9e-18 65.5 0.1 4.8 3 2 1 5 5 1 1 AAA domain AAA_15 PF13175.6 EXF85637.1 - 4.8e-12 46.3 0.2 4.8e-12 46.3 0.2 2.3 2 0 0 2 2 2 1 AAA ATPase domain AAA_21 PF13304.6 EXF85637.1 - 1.1e-06 28.7 0.1 0.00011 22.2 0.1 2.9 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EXF85637.1 - 0.004 16.9 0.0 0.0096 15.6 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain IFT57 PF10498.9 EXF85637.1 - 0.0053 15.8 4.3 0.0053 15.8 4.3 5.5 4 1 2 6 6 6 2 Intra-flagellar transport protein 57 SMC_hinge PF06470.13 EXF85637.1 - 0.021 15.1 0.0 0.063 13.6 0.0 1.9 1 0 0 1 1 1 0 SMC proteins Flexible Hinge Domain SbcCD_C PF13558.6 EXF85637.1 - 0.047 13.9 0.0 0.14 12.4 0.0 1.7 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit Rnk_N PF14760.6 EXF85637.1 - 0.056 13.9 0.9 35 5.0 0.1 4.2 3 0 0 3 3 3 0 Rnk N-terminus AAA_22 PF13401.6 EXF85637.1 - 0.24 11.6 1.6 1.6 9.0 0.0 3.1 2 1 1 3 3 3 0 AAA domain DUF1664 PF07889.12 EXF85637.1 - 0.49 10.4 36.2 0.22 11.6 0.7 6.6 4 2 2 6 6 6 0 Protein of unknown function (DUF1664) ABC_tran PF00005.27 EXF85637.1 - 8 7.0 18.4 0.45 11.0 0.7 4.6 3 2 0 3 3 3 0 ABC transporter COQ9 PF08511.11 EXF85638.1 - 8.6e-31 105.5 0.0 1.3e-30 105.0 0.0 1.3 1 0 0 1 1 1 1 COQ9 RRM_1 PF00076.22 EXF85639.1 - 3.9e-46 154.7 0.0 8.5e-16 57.5 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ATP-grasp_2 PF08442.10 EXF85639.1 - 0.00061 19.4 0.0 0.016 14.7 0.0 2.4 2 0 0 2 2 2 1 ATP-grasp domain Limkain-b1 PF11608.8 EXF85639.1 - 0.00062 19.8 0.2 6.8 6.8 0.0 3.7 4 1 0 4 4 4 1 Limkain b1 RRM_3 PF08777.11 EXF85639.1 - 0.0011 18.9 0.0 2.5 8.2 0.0 3.4 3 1 0 3 3 3 1 RNA binding motif GRP PF07172.11 EXF85639.1 - 0.024 15.3 13.7 0.024 15.3 13.7 4.0 3 1 1 4 4 4 0 Glycine rich protein family PknH_C PF14032.6 EXF85639.1 - 0.025 14.4 0.3 33 4.3 0.0 3.2 3 0 0 3 3 3 0 PknH-like extracellular domain RRM_occluded PF16842.5 EXF85639.1 - 0.043 13.7 0.0 1.8 8.5 0.0 2.6 3 0 0 3 3 3 0 Occluded RNA-recognition motif RRM_5 PF13893.6 EXF85639.1 - 0.087 12.4 0.0 14 5.3 0.0 2.3 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SRP14 PF02290.15 EXF85640.1 - 1.3e-26 92.8 0.0 2e-26 92.2 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle 14kD protein MIF4G PF02854.19 EXF85641.1 - 1.3e-19 70.7 0.0 4.5e-19 68.9 0.0 1.8 2 0 0 2 2 2 1 MIF4G domain MA3 PF02847.17 EXF85641.1 - 2.8e-11 43.4 0.0 8.8e-11 41.8 0.0 1.9 1 0 0 1 1 1 1 MA3 domain Pyr_redox_2 PF07992.14 EXF85642.1 - 9.4e-68 228.6 5.7 1.2e-67 228.3 5.7 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 EXF85642.1 - 2.1e-40 137.4 0.0 4.7e-40 136.3 0.0 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 EXF85642.1 - 6.7e-24 84.3 10.2 6.3e-22 77.9 0.6 3.2 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EXF85642.1 - 5.5e-11 42.5 3.3 6.7e-06 26.2 0.5 2.5 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 EXF85642.1 - 2.3e-10 40.4 7.6 3.1e-09 36.7 0.2 2.5 2 1 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EXF85642.1 - 4.5e-09 35.9 9.6 4.1e-07 29.4 3.6 3.1 3 0 0 3 3 3 2 FAD binding domain GIDA PF01134.22 EXF85642.1 - 6.9e-09 35.3 13.5 8e-08 31.8 4.4 2.9 2 2 1 3 3 3 2 Glucose inhibited division protein A HI0933_like PF03486.14 EXF85642.1 - 6.4e-07 28.4 12.6 0.00013 20.8 1.9 4.1 4 0 0 4 4 4 2 HI0933-like protein Thi4 PF01946.17 EXF85642.1 - 1.7e-06 27.4 2.9 0.00017 21.0 0.1 2.4 2 0 0 2 2 2 2 Thi4 family AlaDh_PNT_C PF01262.21 EXF85642.1 - 2.8e-06 26.8 4.7 0.017 14.5 0.2 2.6 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox_3 PF13738.6 EXF85642.1 - 6.5e-06 25.6 3.5 0.0023 17.2 0.0 2.4 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EXF85642.1 - 1.8e-05 24.5 15.1 0.015 14.9 1.6 4.0 4 0 0 4 4 4 2 FAD dependent oxidoreductase K_oxygenase PF13434.6 EXF85642.1 - 3.1e-05 23.3 0.1 0.23 10.5 0.0 2.7 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) Lycopene_cycl PF05834.12 EXF85642.1 - 5.7e-05 22.3 1.0 0.015 14.3 0.0 2.3 2 0 0 2 2 2 2 Lycopene cyclase protein FAD_binding_3 PF01494.19 EXF85642.1 - 0.022 14.0 9.8 0.94 8.7 1.4 3.0 2 1 0 2 2 2 0 FAD binding domain 3HCDH_N PF02737.18 EXF85642.1 - 0.041 13.8 3.2 0.29 11.0 0.4 2.5 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain RuBisCO_large PF00016.20 EXF85642.1 - 0.2 10.8 3.7 10 5.2 0.1 3.1 3 0 0 3 3 3 0 Ribulose bisphosphate carboxylase large chain, catalytic domain NAD_binding_7 PF13241.6 EXF85642.1 - 1.9 8.9 5.2 3.8 8.0 0.1 3.0 3 1 0 3 3 2 0 Putative NAD(P)-binding Trp_halogenase PF04820.14 EXF85642.1 - 2.2 7.0 7.3 0.73 8.6 1.1 2.1 2 0 0 2 2 2 0 Tryptophan halogenase FYVE_2 PF02318.16 EXF85644.1 - 0.0046 17.2 21.8 0.75 10.0 3.0 3.5 3 0 0 3 3 3 3 FYVE-type zinc finger IBR PF01485.21 EXF85644.1 - 7.4 6.9 37.9 0.69 10.2 5.6 3.7 3 1 0 3 3 3 0 IBR domain, a half RING-finger domain F-box PF00646.33 EXF85646.1 - 1.5e-07 31.1 0.1 4.6e-07 29.5 0.0 1.9 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 EXF85646.1 - 2.4e-07 30.5 0.1 4.4e-07 29.7 0.1 1.5 1 0 0 1 1 1 1 F-box-like UIM PF02809.20 EXF85646.1 - 0.015 15.2 1.2 0.015 15.2 1.2 4.8 5 0 0 5 5 5 0 Ubiquitin interaction motif MerB PF03243.15 EXF85647.1 - 0.0054 16.9 0.0 0.0077 16.4 0.0 1.2 1 0 0 1 1 1 1 Alkylmercury lyase DUF756 PF05506.12 EXF85648.1 - 0.068 14.1 0.0 0.12 13.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF756) Ank_2 PF12796.7 EXF85650.1 - 1.1e-73 243.8 0.0 3.8e-14 53.0 0.0 15.4 9 4 7 16 16 16 9 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EXF85650.1 - 4.8e-66 218.3 16.8 3.8e-08 33.7 0.0 23.4 20 6 6 26 26 26 12 Ankyrin repeats (many copies) Ank PF00023.30 EXF85650.1 - 4.8e-59 194.4 21.7 8.2e-05 22.9 0.0 24.1 25 2 0 25 25 25 10 Ankyrin repeat Ank_3 PF13606.6 EXF85650.1 - 5.1e-47 152.4 2.5 0.00041 20.6 0.0 23.6 25 0 0 25 25 25 7 Ankyrin repeat Ank_5 PF13857.6 EXF85650.1 - 1.8e-46 155.6 24.1 0.00012 22.3 0.0 21.5 20 4 4 24 24 24 11 Ankyrin repeats (many copies) NACHT PF05729.12 EXF85650.1 - 7.4e-06 26.0 0.0 1.8e-05 24.8 0.0 1.7 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 EXF85650.1 - 0.00011 22.6 1.1 0.004 17.6 0.0 3.5 3 0 0 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 EXF85650.1 - 0.0051 17.1 0.0 0.019 15.3 0.0 2.0 1 0 0 1 1 1 1 AAA domain PhoH PF02562.16 EXF85650.1 - 0.19 11.2 0.0 0.43 10.0 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein NB-ARC PF00931.22 EXF85650.1 - 1.1 8.4 2.7 1.7 7.7 0.2 2.5 2 1 0 2 2 2 0 NB-ARC domain Asp PF00026.23 EXF85652.1 - 5.9e-06 25.9 1.1 2.3e-05 24.0 1.1 1.9 1 1 0 1 1 1 1 Eukaryotic aspartyl protease Flavodoxin_1 PF00258.25 EXF85653.1 - 3.2e-30 105.2 0.0 5.1e-30 104.6 0.0 1.3 1 0 0 1 1 1 1 Flavodoxin FAD_binding_1 PF00667.20 EXF85653.1 - 7.8e-24 84.5 0.1 2.1e-22 79.8 0.0 2.1 2 0 0 2 2 2 1 FAD binding domain NAD_binding_1 PF00175.21 EXF85653.1 - 3.2e-07 30.9 0.0 0.00054 20.6 0.0 2.7 1 1 1 2 2 2 2 Oxidoreductase NAD-binding domain Flavodoxin_3 PF12641.7 EXF85653.1 - 0.013 15.2 0.0 0.027 14.2 0.0 1.5 1 0 0 1 1 1 0 Flavodoxin domain Tyrosinase PF00264.20 EXF85656.1 - 6.3e-40 137.8 0.8 1.3e-39 136.8 0.8 1.5 1 1 0 1 1 1 1 Common central domain of tyrosinase AA_permease_2 PF13520.6 EXF85657.1 - 9.7e-80 268.5 34.9 1.2e-79 268.2 34.9 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EXF85657.1 - 1.5e-20 73.2 29.3 2e-20 72.9 29.3 1.1 1 0 0 1 1 1 1 Amino acid permease Aa_trans PF01490.18 EXF85657.1 - 0.00031 19.6 5.0 0.0027 16.5 2.5 2.4 2 0 0 2 2 2 2 Transmembrane amino acid transporter protein DUF2206 PF09971.9 EXF85657.1 - 0.079 11.7 0.2 0.22 10.2 0.0 1.8 2 0 0 2 2 2 0 Predicted membrane protein (DUF2206) DUF2619 PF10942.8 EXF85657.1 - 2.2 8.4 7.2 1.4 9.1 0.5 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2619) CHZ PF09649.10 EXF85658.1 - 3e-05 23.4 0.8 6e-05 22.4 0.8 1.5 1 0 0 1 1 1 1 Histone chaperone domain CHZ Zn_clus PF00172.18 EXF85660.1 - 0.0015 18.6 5.4 0.004 17.3 5.4 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain bZIP_2 PF07716.15 EXF85660.1 - 0.31 11.2 5.4 0.54 10.4 5.4 1.3 1 0 0 1 1 1 0 Basic region leucine zipper Peptidase_S8 PF00082.22 EXF85662.1 - 1.1e-32 113.5 0.0 1e-31 110.3 0.0 2.5 1 1 0 1 1 1 1 Subtilase family fn3_5 PF06280.12 EXF85662.1 - 4.6e-11 43.4 1.9 7.1e-11 42.8 0.0 2.2 2 0 0 2 2 2 1 Fn3-like domain DUF916 PF06030.12 EXF85662.1 - 0.17 12.0 0.1 0.55 10.3 0.1 1.8 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF916) MSP1_C PF07462.11 EXF85662.1 - 4.8 5.8 5.3 9.6 4.8 5.3 1.4 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus zf-C2H2 PF00096.26 EXF85663.1 - 0.16 12.5 4.4 0.77 10.3 0.0 3.4 3 0 0 3 3 3 0 Zinc finger, C2H2 type FOXP-CC PF16159.5 EXF85663.1 - 0.49 11.1 8.6 0.81 10.4 4.2 3.0 1 1 2 3 3 3 0 FOXP coiled-coil domain CUE PF02845.16 EXF85664.1 - 3.4e-06 26.7 0.0 6e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 CUE domain TipAS PF07739.13 EXF85664.1 - 0.71 10.4 3.2 4.9 7.7 0.1 2.8 3 0 0 3 3 3 0 TipAS antibiotic-recognition domain NOA36 PF06524.12 EXF85664.1 - 0.76 9.1 4.7 1.3 8.3 4.7 1.2 1 0 0 1 1 1 0 NOA36 protein API5 PF05918.11 EXF85664.1 - 8.6 5.0 5.5 17 4.1 5.5 1.5 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) Ribosomal_S10 PF00338.22 EXF85665.1 - 1.6e-26 92.4 0.2 1.9e-26 92.1 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e Fibrillarin_2 PF10113.9 EXF85665.1 - 0.0089 14.7 0.0 0.0089 14.7 0.0 1.1 1 0 0 1 1 1 1 Fibrillarin-like archaeal protein zf-CCCH_4 PF18044.1 EXF85666.1 - 1.7e-08 34.0 3.6 3.1e-08 33.2 3.6 1.5 1 0 0 1 1 1 1 CCCH-type zinc finger zf_CCCH_4 PF18345.1 EXF85666.1 - 2.1e-06 27.6 7.7 4e-06 26.7 7.7 1.5 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH PF00642.24 EXF85666.1 - 2.9e-05 23.9 3.2 5.1e-05 23.1 3.2 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Nucleoporin_FG PF13634.6 EXF85666.1 - 0.0072 17.1 22.3 0.0072 17.1 22.3 7.7 3 2 4 7 7 7 4 Nucleoporin FG repeat region Torus PF16131.5 EXF85666.1 - 0.036 14.8 0.7 0.07 13.8 0.7 1.5 1 0 0 1 1 1 0 Torus domain zf-CCCH_2 PF14608.6 EXF85666.1 - 0.78 10.3 4.4 1.6 9.3 4.4 1.5 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger Cellulase PF00150.18 EXF85667.1 - 2e-18 66.8 0.2 5.3e-18 65.4 0.2 1.6 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) p450 PF00067.22 EXF85668.1 - 8.5e-60 202.8 0.0 1.1e-59 202.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Fungal_trans PF04082.18 EXF85669.1 - 2.1e-23 82.7 0.1 4.1e-23 81.7 0.1 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF85669.1 - 2.2e-07 30.9 12.6 5.2e-07 29.7 12.6 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Peptidase_C12 PF01088.21 EXF85672.1 - 2.9e-56 190.5 0.0 3.5e-56 190.3 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 SUV3_C PF12513.8 EXF85673.1 - 4e-17 61.9 0.3 8.8e-17 60.8 0.3 1.6 1 0 0 1 1 1 1 Mitochondrial degradasome RNA helicase subunit C terminal Helicase_C PF00271.31 EXF85673.1 - 1.5e-10 41.4 0.0 7.6e-10 39.1 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Suv3_C_1 PF18147.1 EXF85673.1 - 3e-09 36.6 0.8 5.3e-09 35.8 0.0 1.9 2 0 0 2 2 2 1 Suv3 C-terminal domain 1 DUF4771 PF15995.5 EXF85673.1 - 0.074 13.3 0.3 0.2 11.9 0.3 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4771) Synaptobrevin PF00957.21 EXF85674.1 - 2.8e-32 110.3 0.5 3.8e-32 109.9 0.5 1.2 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 EXF85674.1 - 8.1e-30 102.7 0.0 1.4e-29 101.9 0.0 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain TFIIA PF03153.13 EXF85675.1 - 0.037 14.0 12.6 0.037 14.0 12.6 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Suf PF05843.14 EXF85675.1 - 0.082 12.9 7.9 0.096 12.6 7.9 1.0 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF2967 PF11179.8 EXF85675.1 - 0.24 9.5 5.7 0.28 9.2 5.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2967) Spt20 PF12090.8 EXF85675.1 - 0.43 10.1 15.0 0.5 9.9 15.0 1.1 1 0 0 1 1 1 0 Spt20 family Med3 PF11593.8 EXF85675.1 - 6.4 5.9 21.5 12 5.0 21.5 1.5 1 1 0 1 1 1 0 Mediator complex subunit 3 fungal adh_short PF00106.25 EXF85676.1 - 2.7e-12 46.5 0.0 2.5e-11 43.4 0.0 2.4 2 1 0 2 2 2 1 short chain dehydrogenase Epimerase PF01370.21 EXF85676.1 - 2.6e-06 27.1 0.0 4.9e-06 26.2 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family KR PF08659.10 EXF85676.1 - 7e-05 22.8 0.0 0.00021 21.3 0.0 1.7 2 0 0 2 2 2 1 KR domain adh_short_C2 PF13561.6 EXF85676.1 - 9e-05 22.1 0.0 0.0031 17.1 0.0 2.4 3 0 0 3 3 3 1 Enoyl-(Acyl carrier protein) reductase GDP_Man_Dehyd PF16363.5 EXF85676.1 - 0.01 15.2 0.0 0.035 13.5 0.0 1.8 1 1 0 1 1 1 0 GDP-mannose 4,6 dehydratase E1-N PF14463.6 EXF85676.1 - 0.032 14.0 0.1 0.055 13.3 0.1 1.4 1 0 0 1 1 1 0 E1 N-terminal domain p25-alpha PF05517.12 EXF85676.1 - 0.29 11.3 7.4 0.47 10.6 7.4 1.3 1 0 0 1 1 1 0 p25-alpha CENP-Q PF13094.6 EXF85676.1 - 0.3 11.3 12.2 0.44 10.7 12.2 1.2 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit G-patch PF01585.23 EXF85677.1 - 9.9e-06 25.4 0.3 2.4e-05 24.1 0.3 1.7 1 0 0 1 1 1 1 G-patch domain LPMO_10 PF03067.15 EXF85677.1 - 0.0053 17.4 0.0 0.0075 16.9 0.0 1.3 1 0 0 1 1 1 1 Lytic polysaccharide mono-oxygenase, cellulose-degrading Sec1 PF00995.23 EXF85678.1 - 1.2e-115 388.0 0.0 1.4e-115 387.7 0.0 1.0 1 0 0 1 1 1 1 Sec1 family SET PF00856.28 EXF85680.1 - 5.6e-13 49.6 0.0 1.3e-12 48.4 0.0 1.6 1 1 0 1 1 1 1 SET domain DUF4691 PF15762.5 EXF85680.1 - 0.017 15.3 0.1 0.026 14.7 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4691) Npa1 PF11707.8 EXF85681.1 - 1.5e-99 333.6 0.0 3.3e-99 332.5 0.0 1.6 1 0 0 1 1 1 1 Ribosome 60S biogenesis N-terminal NopRA1 PF16201.5 EXF85681.1 - 1.1e-60 204.7 2.1 1.6e-58 197.6 0.1 4.4 5 0 0 5 5 5 1 Nucleolar pre-ribosomal-associated protein 1 Adaptin_N PF01602.20 EXF85681.1 - 0.0029 16.2 0.1 0.23 10.0 0.0 3.0 3 0 0 3 3 3 1 Adaptin N terminal region DIM1 PF02966.16 EXF85682.1 - 5.9e-70 233.2 0.3 6.7e-70 233.0 0.3 1.0 1 0 0 1 1 1 1 Mitosis protein DIM1 MOR2-PAG1_N PF14222.6 EXF85683.1 - 4.3e-220 732.3 0.0 6.5e-220 731.8 0.0 1.3 1 0 0 1 1 1 1 Cell morphogenesis N-terminal MOR2-PAG1_C PF14225.6 EXF85683.1 - 1.9e-92 309.7 1.2 2.7e-92 309.2 0.1 1.9 2 0 0 2 2 2 1 Cell morphogenesis C-terminal MOR2-PAG1_mid PF14228.6 EXF85683.1 - 1.1e-38 132.6 7.1 2.1e-18 65.5 0.1 3.4 2 1 1 3 3 3 3 Cell morphogenesis central region HEAT_2 PF13646.6 EXF85683.1 - 0.13 12.7 0.3 36 4.8 0.0 4.9 5 1 0 5 5 5 0 HEAT repeats FAD_binding_1 PF00667.20 EXF85684.1 - 1.5e-61 207.8 0.0 2.3e-61 207.2 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 EXF85684.1 - 6.5e-33 113.9 0.6 1.5e-32 112.8 0.6 1.6 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 EXF85684.1 - 4.1e-19 69.2 0.0 1.5e-18 67.4 0.0 1.9 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain Flavodoxin_5 PF12724.7 EXF85684.1 - 0.088 13.1 0.1 0.32 11.2 0.0 2.0 2 0 0 2 2 2 0 Flavodoxin domain RRM_1 PF00076.22 EXF85685.1 - 3e-25 87.8 0.0 3.5e-11 42.8 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RIO1 PF01163.22 EXF85686.1 - 6.3e-42 143.3 0.1 4.4e-29 101.4 0.0 2.2 2 0 0 2 2 2 2 RIO1 family Rio2_N PF09202.11 EXF85686.1 - 3.5e-29 100.8 0.1 1.2e-28 99.1 0.1 1.9 2 0 0 2 2 2 1 Rio2, N-terminal APH PF01636.23 EXF85686.1 - 4.9e-08 33.2 0.0 0.00023 21.2 0.0 2.6 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 EXF85686.1 - 1.3e-05 24.6 0.0 0.0013 18.1 0.0 2.5 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Raftlin PF15250.6 EXF85686.1 - 0.69 8.6 3.3 1.1 8.0 3.3 1.2 1 0 0 1 1 1 0 Raftlin NOA36 PF06524.12 EXF85686.1 - 4.3 6.6 9.8 6.4 6.0 9.8 1.2 1 0 0 1 1 1 0 NOA36 protein DUF2457 PF10446.9 EXF85686.1 - 7.3 5.6 15.6 11 5.1 15.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) RPN1_RPN2_N PF17781.1 EXF85687.1 - 2.3e-112 375.4 1.6 3.7e-112 374.7 1.6 1.3 1 0 0 1 1 1 1 RPN1/RPN2 N-terminal domain RPN1_C PF18051.1 EXF85687.1 - 4.8e-29 100.2 0.0 8.3e-29 99.4 0.0 1.4 1 0 0 1 1 1 1 26S proteasome non-ATPase regulatory subunit RPN1 C-terminal PC_rep PF01851.22 EXF85687.1 - 1.3e-19 69.5 11.8 9e-05 22.7 0.2 8.2 7 0 0 7 7 7 3 Proteasome/cyclosome repeat HEAT_2 PF13646.6 EXF85687.1 - 9.2e-08 32.4 0.7 0.0095 16.3 0.0 4.4 5 1 1 6 6 6 3 HEAT repeats DUF848 PF05852.11 EXF85687.1 - 0.096 12.8 2.0 0.23 11.6 2.0 1.6 1 0 0 1 1 1 0 Gammaherpesvirus protein of unknown function (DUF848) Pinin_SDK_memA PF04696.13 EXF85687.1 - 0.21 11.6 2.5 0.41 10.7 2.5 1.3 1 0 0 1 1 1 0 pinin/SDK/memA/ protein conserved region HAND PF09110.11 EXF85687.1 - 0.29 11.9 6.9 0.62 10.8 6.9 1.5 1 0 0 1 1 1 0 HAND MatE PF01554.18 EXF85688.1 - 4.5e-55 185.7 28.3 2.8e-34 118.1 9.6 2.2 2 0 0 2 2 2 2 MatE NUDIX PF00293.28 EXF85689.1 - 1.2e-27 96.5 0.0 1.8e-27 95.9 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain Acetyltransf_1 PF00583.25 EXF85690.1 - 3.7e-08 33.6 0.1 6.3e-08 32.9 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EXF85690.1 - 4.3e-07 29.9 0.0 7.2e-07 29.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EXF85690.1 - 4.9e-07 30.1 0.0 8.8e-07 29.3 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EXF85690.1 - 8.5e-07 29.1 0.0 1.5e-06 28.3 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EXF85690.1 - 0.0042 17.2 0.0 0.0076 16.4 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase GNAT_acetyltran PF12746.7 EXF85690.1 - 0.018 14.6 0.0 0.03 13.9 0.0 1.2 1 0 0 1 1 1 0 GNAT acetyltransferase FR47 PF08445.10 EXF85690.1 - 0.05 13.6 0.0 0.095 12.7 0.0 1.4 1 0 0 1 1 1 0 FR47-like protein RPA_C PF08784.11 EXF85691.1 - 2.6e-18 66.6 0.7 8.1e-18 65.0 0.1 2.1 2 0 0 2 2 2 1 Replication protein A C terminal tRNA_anti-codon PF01336.25 EXF85691.1 - 1.2e-08 34.8 0.1 3.4e-08 33.4 0.0 1.7 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain Lon_C PF05362.13 EXF85692.1 - 1.6e-68 230.3 0.7 6.7e-68 228.3 0.4 2.0 2 0 0 2 2 2 1 Lon protease (S16) C-terminal proteolytic domain LON_substr_bdg PF02190.16 EXF85692.1 - 1.7e-27 96.7 0.0 3.4e-27 95.7 0.0 1.6 1 0 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain AAA PF00004.29 EXF85692.1 - 1.3e-22 80.6 0.0 3.4e-22 79.3 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ChlI PF13541.6 EXF85692.1 - 5.6e-09 35.9 0.1 8.5e-08 32.1 0.0 2.4 2 0 0 2 2 2 1 Subunit ChlI of Mg-chelatase AAA_5 PF07728.14 EXF85692.1 - 2.6e-07 30.7 0.0 8.3e-07 29.1 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 EXF85692.1 - 1.9e-05 24.4 0.0 5e-05 23.1 0.0 1.7 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_16 PF13191.6 EXF85692.1 - 5.7e-05 23.6 1.8 0.00017 22.0 0.1 2.4 1 1 1 2 2 2 1 AAA ATPase domain AAA_3 PF07726.11 EXF85692.1 - 0.00028 20.7 0.0 0.00064 19.6 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EXF85692.1 - 0.00038 20.2 0.0 0.0014 18.4 0.0 1.9 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EXF85692.1 - 0.00049 20.4 0.0 0.025 14.9 0.0 2.8 1 1 0 1 1 1 1 AAA domain AAA_2 PF07724.14 EXF85692.1 - 0.00073 19.7 0.0 0.005 17.0 0.0 2.3 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) TIP49 PF06068.13 EXF85692.1 - 0.0018 17.5 0.1 0.0035 16.6 0.1 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_25 PF13481.6 EXF85692.1 - 0.016 14.8 0.0 0.055 13.0 0.0 1.9 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 EXF85692.1 - 0.022 14.7 0.0 0.066 13.1 0.0 1.8 1 0 0 1 1 1 0 NACHT domain AAA_18 PF13238.6 EXF85692.1 - 0.03 14.9 0.0 0.08 13.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EXF85692.1 - 0.031 14.4 0.0 0.074 13.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 EXF85692.1 - 0.045 13.6 0.0 0.14 12.0 0.0 1.8 1 0 0 1 1 1 0 RsgA GTPase TsaE PF02367.17 EXF85692.1 - 0.092 12.7 0.0 0.2 11.7 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NTPase_1 PF03266.15 EXF85692.1 - 0.1 12.5 0.0 0.32 10.9 0.0 1.9 1 1 0 1 1 1 0 NTPase RNA_helicase PF00910.22 EXF85692.1 - 0.1 13.0 0.0 0.37 11.2 0.0 2.0 2 0 0 2 2 1 0 RNA helicase AAA_23 PF13476.6 EXF85692.1 - 0.2 12.1 0.0 0.2 12.1 0.0 3.5 2 1 1 3 3 1 0 AAA domain Pilin_PilX PF11530.8 EXF85692.1 - 0.21 11.5 0.0 0.44 10.5 0.0 1.4 1 0 0 1 1 1 0 Minor type IV pilin, PilX AAA_11 PF13086.6 EXF85692.1 - 0.37 10.5 0.0 0.37 10.5 0.0 2.4 1 1 1 2 2 2 0 AAA domain Lactonase PF10282.9 EXF85694.1 - 2.3e-75 254.0 0.1 3.1e-75 253.6 0.1 1.0 1 0 0 1 1 1 1 Lactonase, 7-bladed beta-propeller DUF3328 PF11807.8 EXF85695.1 - 9.3e-30 104.0 3.4 5.7e-29 101.5 3.4 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF3328) Peptidase_S10 PF00450.22 EXF85696.1 - 1.9e-79 268.1 0.3 3.4e-79 267.2 0.3 1.4 1 1 0 1 1 1 1 Serine carboxypeptidase adh_short PF00106.25 EXF85697.1 - 5.3e-23 81.5 0.0 2e-22 79.6 0.0 1.8 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF85697.1 - 1e-12 48.1 0.0 2.3e-12 47.0 0.0 1.5 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF85697.1 - 2.2e-07 31.0 0.1 4.1e-07 30.1 0.1 1.5 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 EXF85697.1 - 1.5e-06 27.9 0.0 2.4e-06 27.2 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EXF85697.1 - 0.00028 20.4 0.0 0.00038 20.0 0.0 1.1 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 EXF85697.1 - 0.042 13.8 0.1 0.3 11.0 0.0 2.1 2 1 0 2 2 2 0 NAD(P)H-binding AdoHcyase_NAD PF00670.21 EXF85697.1 - 0.051 13.6 0.3 0.2 11.7 0.1 1.8 1 1 0 2 2 2 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain FAD_binding_4 PF01565.23 EXF85698.1 - 3.5e-25 88.4 3.3 6.2e-25 87.6 3.3 1.4 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EXF85698.1 - 3e-09 36.8 0.0 7.5e-09 35.6 0.0 1.7 1 0 0 1 1 1 1 Berberine and berberine like HET PF06985.11 EXF85699.1 - 6.8e-26 91.4 0.0 5.4e-22 78.7 0.0 2.4 2 0 0 2 2 2 2 Heterokaryon incompatibility protein (HET) adh_short_C2 PF13561.6 EXF85700.1 - 6.5e-19 68.4 0.0 1.1e-18 67.7 0.0 1.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF85700.1 - 7.5e-09 35.3 0.0 4.6e-08 32.7 0.0 1.9 1 1 0 1 1 1 1 short chain dehydrogenase Eno-Rase_NADH_b PF12242.8 EXF85700.1 - 0.0047 16.7 0.0 0.0083 15.9 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase EF-hand_1 PF00036.32 EXF85701.1 - 7.8e-13 47.0 4.1 3.7e-05 23.0 0.5 4.4 4 0 0 4 4 4 2 EF hand ZZ PF00569.17 EXF85701.1 - 4e-10 39.3 7.3 6.9e-10 38.6 7.3 1.3 1 0 0 1 1 1 1 Zinc finger, ZZ type EF-hand_6 PF13405.6 EXF85701.1 - 2.3e-08 33.3 4.9 0.00069 19.4 0.4 4.4 4 0 0 4 4 4 2 EF-hand domain EF-hand_7 PF13499.6 EXF85701.1 - 2.5e-06 27.9 11.6 0.003 18.0 0.4 4.2 3 1 0 4 4 4 3 EF-hand domain pair EF-hand_8 PF13833.6 EXF85701.1 - 0.0011 18.7 4.9 0.84 9.5 0.1 3.5 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_4 PF12763.7 EXF85701.1 - 0.019 14.9 0.1 0.16 11.9 0.0 2.5 2 1 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand C1_2 PF03107.16 EXF85701.1 - 0.09 13.1 9.4 0.16 12.3 9.4 1.4 1 0 0 1 1 1 0 C1 domain Dockerin_1 PF00404.18 EXF85701.1 - 0.1 12.8 0.2 0.33 11.2 0.0 1.9 2 0 0 2 2 2 0 Dockerin type I domain EF-hand_5 PF13202.6 EXF85701.1 - 1.3 8.7 10.0 1.3 8.6 0.7 3.5 3 0 0 3 3 3 0 EF hand Abhydrolase_1 PF00561.20 EXF85702.1 - 1e-12 48.3 0.0 9.1e-12 45.2 0.0 1.9 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EXF85702.1 - 1.4e-11 45.5 0.7 2.1e-11 44.9 0.7 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EXF85702.1 - 2.5e-11 43.3 0.3 1.3e-10 41.0 0.1 2.1 1 1 1 2 2 2 1 Serine aminopeptidase, S33 Esterase PF00756.20 EXF85702.1 - 0.0038 16.9 0.1 0.0088 15.7 0.1 1.6 1 0 0 1 1 1 1 Putative esterase Peptidase_S9 PF00326.21 EXF85702.1 - 0.053 13.0 0.0 0.21 11.0 0.0 2.0 2 0 0 2 2 2 0 Prolyl oligopeptidase family Esterase_phd PF10503.9 EXF85702.1 - 0.14 11.6 0.2 0.66 9.4 0.0 1.9 2 0 0 2 2 2 0 Esterase PHB depolymerase PGAP1 PF07819.13 EXF85702.1 - 0.14 11.8 0.1 0.36 10.5 0.1 1.7 1 1 0 1 1 1 0 PGAP1-like protein NMT_C PF02799.15 EXF85703.1 - 7.9e-84 280.4 0.0 1.2e-83 279.8 0.0 1.2 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain NMT PF01233.19 EXF85703.1 - 1.2e-72 243.0 0.5 8.9e-72 240.1 0.0 2.0 2 0 0 2 2 2 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain Acetyltransf_9 PF13527.7 EXF85703.1 - 0.00011 22.3 0.2 0.007 16.4 0.0 2.3 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EXF85703.1 - 0.011 15.9 0.0 0.027 14.7 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family DUF1576 PF07613.11 EXF85703.1 - 0.029 13.9 0.0 3.9 7.0 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1576) DUF3024 PF11225.8 EXF85703.1 - 0.11 12.8 0.0 0.24 11.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3024) CMS1 PF14617.6 EXF85703.1 - 0.33 10.2 2.2 0.37 10.1 0.8 1.7 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit DUF4598 PF15370.6 EXF85703.1 - 0.48 10.9 5.8 2.2 8.8 5.8 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4598) TSGP1 PF07771.11 EXF85703.1 - 2.5 8.3 6.4 4.8 7.4 6.4 1.4 1 0 0 1 1 1 0 Tick salivary peptide group 1 DUF3381 PF11861.8 EXF85703.1 - 4 7.2 9.6 8.4 6.2 9.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) Abhydrolase_6 PF12697.7 EXF85704.1 - 6.6e-11 43.2 0.4 6.6e-11 43.2 0.4 1.7 2 0 0 2 2 2 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EXF85704.1 - 2.7e-08 33.4 0.1 5.8e-08 32.3 0.1 1.4 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EXF85704.1 - 4.2e-08 33.2 0.1 5.9e-08 32.7 0.1 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S15 PF02129.18 EXF85704.1 - 0.018 14.7 0.1 0.039 13.5 0.1 1.5 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Tfb2_C PF18307.1 EXF85704.1 - 0.057 13.8 0.1 28 5.2 0.0 3.2 3 0 0 3 3 3 0 Transcription factor Tfb2 (p52) C-terminal domain Abhydrolase_3 PF07859.13 EXF85704.1 - 0.079 12.8 0.1 0.13 12.1 0.1 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold AXE1 PF05448.12 EXF85704.1 - 0.26 9.9 0.4 0.52 8.9 0.2 1.5 1 1 1 2 2 2 0 Acetyl xylan esterase (AXE1) MSA-2c PF12238.8 EXF85705.1 - 0.0088 16.1 2.6 0.0088 16.1 2.6 5.8 4 1 0 4 4 4 1 Merozoite surface antigen 2c Androgen_recep PF02166.16 EXF85706.1 - 7.6 5.3 7.0 4.2 6.1 0.5 2.1 2 0 0 2 2 2 0 Androgen receptor TLD PF07534.16 EXF85707.1 - 1.3e-29 103.1 0.0 4.2e-29 101.5 0.0 1.9 2 1 0 2 2 2 1 TLD DUF1773 PF08593.10 EXF85707.1 - 8.9e-18 65.1 1.4 1.8e-17 64.1 0.5 2.1 2 0 0 2 2 2 1 Domain of unknown function HIG_1_N PF04588.13 EXF85708.1 - 5.9e-22 77.6 0.6 1.3e-21 76.5 0.5 1.7 2 0 0 2 2 2 1 Hypoxia induced protein conserved region PALP PF00291.25 EXF85709.1 - 1.7e-77 260.7 0.8 2.1e-77 260.4 0.8 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Thr_dehydrat_C PF00585.18 EXF85709.1 - 2.8e-41 139.2 0.0 1.8e-20 72.5 0.0 2.3 2 0 0 2 2 2 2 C-terminal regulatory domain of Threonine dehydratase Ribosomal_L36 PF00444.18 EXF85710.1 - 5.6e-21 74.5 11.0 8e-21 74.0 11.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L36 Ribosomal_L35p PF01632.19 EXF85710.1 - 0.49 10.9 7.3 0.37 11.3 5.1 2.0 2 1 0 2 2 2 0 Ribosomal protein L35 Complex1_LYR PF05347.15 EXF85711.1 - 5.4e-21 74.4 0.2 6.3e-21 74.2 0.2 1.1 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 EXF85711.1 - 4.4e-08 33.8 0.0 4.9e-08 33.6 0.0 1.1 1 0 0 1 1 1 1 Complex1_LYR-like Acetyltransf_1 PF00583.25 EXF85712.1 - 1.7e-13 50.9 0.0 2.4e-13 50.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EXF85712.1 - 1.3e-08 35.1 0.0 2.1e-08 34.5 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EXF85712.1 - 5.3e-06 26.4 0.0 8.3e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 EXF85712.1 - 0.00012 22.8 0.1 0.00017 22.3 0.1 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EXF85712.1 - 0.00064 19.6 0.0 0.0013 18.6 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_4 PF13420.7 EXF85712.1 - 0.003 17.7 0.0 0.0044 17.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EXF85712.1 - 0.055 13.6 0.0 0.12 12.6 0.0 1.5 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase PLAC8 PF04749.17 EXF85713.1 - 4e-24 85.5 11.8 5.4e-24 85.1 11.8 1.2 1 0 0 1 1 1 1 PLAC8 family TFIIA PF03153.13 EXF85713.1 - 0.37 10.7 20.4 0.45 10.5 20.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Nucleo_P87 PF07267.11 EXF85713.1 - 8.7 5.1 11.2 12 4.7 11.2 1.0 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 DUF456 PF04306.13 EXF85714.1 - 0.0087 16.3 2.1 0.015 15.6 1.8 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF456) MscS_TM PF12794.7 EXF85714.1 - 0.098 11.5 0.0 0.13 11.1 0.0 1.1 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 DUF3632 PF12311.8 EXF85718.1 - 0.0005 20.6 3.3 0.00062 20.3 1.0 2.3 2 1 0 2 2 2 1 Protein of unknown function (DUF3632) p450 PF00067.22 EXF85719.1 - 7.1e-62 209.6 0.0 9.1e-62 209.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Ferric_reduct PF01794.19 EXF85720.1 - 3e-23 82.3 15.7 9.1e-23 80.7 15.7 1.9 1 0 0 1 1 1 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 EXF85720.1 - 1.1e-15 58.1 0.0 9.5e-15 55.1 0.0 2.1 1 1 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EXF85720.1 - 1e-09 38.4 0.0 1.8e-08 34.4 0.0 2.3 1 1 0 1 1 1 1 FAD-binding domain NAD_binding_1 PF00175.21 EXF85720.1 - 0.2 12.3 0.0 0.73 10.5 0.0 2.0 1 1 0 1 1 1 0 Oxidoreductase NAD-binding domain GFA PF04828.14 EXF85721.1 - 6.3e-11 42.5 0.7 1.1e-10 41.8 0.2 1.6 2 0 0 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme D_CNTX PF17492.2 EXF85721.1 - 0.11 12.7 0.1 0.11 12.7 0.1 2.4 2 1 0 2 2 2 0 Delta Ctenitoxins Glyco_trans_2_3 PF13632.6 EXF85723.1 - 7.8e-19 68.4 0.1 7.8e-19 68.4 0.1 2.4 2 0 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 EXF85723.1 - 8.9e-18 65.0 0.0 1.4e-17 64.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 EXF85723.1 - 1.3e-12 47.9 0.0 2.3e-12 47.0 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 2 Cellulose_synt PF03552.14 EXF85723.1 - 1.6e-12 46.8 4.6 5e-09 35.2 0.1 3.6 2 1 2 4 4 4 2 Cellulose synthase Glyco_transf_21 PF13506.6 EXF85723.1 - 2.8e-12 46.4 0.0 4.6e-12 45.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 21 CBFD_NFYB_HMF PF00808.23 EXF85724.1 - 4.9e-11 42.8 0.0 1e-10 41.8 0.0 1.6 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EXF85724.1 - 9e-07 29.3 0.3 9e-07 29.3 0.3 2.2 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 EXF85724.1 - 0.0034 17.5 0.0 0.0074 16.4 0.0 1.5 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold Paf1 PF03985.13 EXF85724.1 - 0.059 12.4 13.6 0.1 11.6 13.6 1.4 1 0 0 1 1 1 0 Paf1 TAFII28 PF04719.14 EXF85724.1 - 0.085 13.0 0.0 0.17 12.0 0.0 1.5 1 0 0 1 1 1 0 hTAFII28-like protein conserved region TFIIA PF03153.13 EXF85724.1 - 0.13 12.2 20.3 0.2 11.6 20.3 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Cwf_Cwc_15 PF04889.12 EXF85724.1 - 0.8 9.4 23.4 0.16 11.7 18.7 1.9 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein NOA36 PF06524.12 EXF85724.1 - 1.5 8.1 16.5 2.6 7.3 16.5 1.4 1 0 0 1 1 1 0 NOA36 protein CDC27 PF09507.10 EXF85724.1 - 1.6 8.1 36.1 0.5 9.7 14.5 2.1 2 0 0 2 2 2 0 DNA polymerase subunit Cdc27 Hamartin PF04388.12 EXF85724.1 - 3.4 6.2 17.8 4.5 5.8 17.8 1.1 1 0 0 1 1 1 0 Hamartin protein DUF3464 PF11947.8 EXF85724.1 - 5.2 6.8 10.2 2.7 7.7 0.2 2.5 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 SnoaL_2 PF12680.7 EXF85725.1 - 0.00051 20.6 0.1 0.00064 20.3 0.1 1.2 1 0 0 1 1 1 1 SnoaL-like domain SnoaL_4 PF13577.6 EXF85725.1 - 0.0063 16.6 0.1 0.0084 16.2 0.1 1.2 1 0 0 1 1 1 1 SnoaL-like domain DUF1308 PF07000.11 EXF85726.1 - 0.00079 19.4 0.0 0.02 14.9 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF1308) NAD_binding_2 PF03446.15 EXF85727.1 - 3.4e-68 228.8 4.8 4.8e-36 124.3 1.6 2.9 3 0 0 3 3 3 2 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 EXF85727.1 - 1.7e-67 225.2 2.0 1.4e-34 119.0 0.1 2.6 2 0 0 2 2 2 2 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase SBD_N PF07005.11 EXF85727.1 - 1.8e-59 201.3 0.0 3.6e-59 200.3 0.0 1.5 1 0 0 1 1 1 1 Sugar-binding N-terminal domain NBD_C PF17042.5 EXF85727.1 - 7.1e-44 150.3 1.7 2.2e-43 148.7 1.7 2.0 1 0 0 1 1 1 1 Nucleotide-binding C-terminal domain 2-Hacid_dh_C PF02826.19 EXF85727.1 - 8.3e-12 44.8 0.0 9.4e-06 25.1 0.0 2.5 2 0 0 2 2 2 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain F420_oxidored PF03807.17 EXF85727.1 - 1e-11 45.3 4.3 0.00012 22.5 0.4 5.2 4 2 1 6 6 6 2 NADP oxidoreductase coenzyme F420-dependent 3HCDH_N PF02737.18 EXF85727.1 - 7.1e-07 29.3 0.8 0.00073 19.5 0.4 2.5 2 0 0 2 2 2 2 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ApbA PF02558.16 EXF85727.1 - 0.00047 19.8 1.2 0.053 13.2 0.1 2.8 3 0 0 3 3 3 1 Ketopantoate reductase PanE/ApbA UDPG_MGDP_dh PF00984.19 EXF85727.1 - 0.016 15.4 0.6 11 6.3 0.0 3.4 4 1 0 4 4 4 0 UDP-glucose/GDP-mannose dehydrogenase family, central domain UDPG_MGDP_dh_N PF03721.14 EXF85727.1 - 0.035 13.7 0.5 2.2 7.8 0.3 3.4 2 1 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh_C PF03720.15 EXF85727.1 - 0.047 14.1 0.0 2.4 8.6 0.0 2.7 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain Zn_clus PF00172.18 EXF85728.1 - 2.1e-06 27.8 7.2 3.2e-06 27.1 7.2 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EXF85728.1 - 5.2e-06 25.7 1.6 2e-05 23.7 0.1 2.3 3 0 0 3 3 3 1 Fungal specific transcription factor domain RHD_DNA_bind PF00554.22 EXF85728.1 - 0.14 12.1 0.5 0.25 11.3 0.5 1.3 1 0 0 1 1 1 0 Rel homology DNA-binding domain DUF4503 PF14951.6 EXF85728.1 - 0.7 8.3 4.4 1.2 7.6 4.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4503) MFS_1 PF07690.16 EXF85729.1 - 2.9e-34 118.5 36.6 2.9e-34 118.5 36.6 1.9 2 0 0 2 2 2 2 Major Facilitator Superfamily p450 PF00067.22 EXF85731.1 - 5.6e-78 262.7 0.0 7.5e-78 262.3 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 FAD_binding_1 PF00667.20 EXF85731.1 - 1.2e-28 100.2 0.0 2.1e-28 99.4 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 EXF85731.1 - 1.5e-24 86.8 0.0 3.8e-24 85.5 0.0 1.7 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 EXF85731.1 - 6.5e-14 52.5 0.0 1.9e-13 51.0 0.0 1.9 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Flavodoxin_5 PF12724.7 EXF85731.1 - 0.0013 19.0 0.0 0.003 17.8 0.0 1.6 1 0 0 1 1 1 1 Flavodoxin domain DUF4296 PF14129.6 EXF85731.1 - 0.057 14.0 0.1 0.2 12.3 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4296) Abhydrolase_3 PF07859.13 EXF85732.1 - 1.2e-49 169.0 0.0 1.5e-49 168.7 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 EXF85732.1 - 0.00046 19.2 0.1 0.0021 17.0 0.1 1.8 1 1 0 1 1 1 1 Carboxylesterase family Peptidase_S9 PF00326.21 EXF85732.1 - 0.037 13.5 0.1 7.3 6.0 0.0 2.2 2 0 0 2 2 2 0 Prolyl oligopeptidase family AXE1 PF05448.12 EXF85732.1 - 0.25 10.0 0.0 0.38 9.4 0.0 1.2 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) MFS_1 PF07690.16 EXF85733.1 - 2.6e-17 62.8 48.0 3.1e-14 52.7 27.9 2.5 2 1 1 3 3 3 2 Major Facilitator Superfamily TRI12 PF06609.13 EXF85733.1 - 4.9e-05 22.0 7.8 4.9e-05 22.0 7.8 2.8 3 1 0 3 3 3 1 Fungal trichothecene efflux pump (TRI12) Insulin_TMD PF17870.1 EXF85733.1 - 0.042 13.9 0.7 0.35 11.0 0.7 2.7 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment Peptidase_C2 PF00648.21 EXF85734.1 - 1.2e-63 214.9 4.2 1.7e-62 211.2 4.2 2.1 1 1 0 1 1 1 1 Calpain family cysteine protease Peptidase_S10 PF00450.22 EXF85735.1 - 9.5e-77 259.1 0.0 1.6e-39 136.5 0.2 2.0 1 1 0 2 2 2 2 Serine carboxypeptidase Zn_clus PF00172.18 EXF85736.1 - 4.8e-08 33.0 8.2 9.1e-08 32.1 8.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EXF85736.1 - 0.0014 17.6 0.1 0.003 16.4 0.1 1.6 1 1 0 1 1 1 1 Fungal specific transcription factor domain Protamine_P2 PF00841.19 EXF85737.1 - 0.17 12.4 0.3 0.39 11.2 0.3 1.5 1 0 0 1 1 1 0 Sperm histone P2 NPP1 PF05630.11 EXF85738.1 - 2e-45 155.4 0.0 2.4e-45 155.1 0.0 1.1 1 0 0 1 1 1 1 Necrosis inducing protein (NPP1) LysM PF01476.20 EXF85739.1 - 0.0033 17.5 0.0 0.0063 16.6 0.0 1.4 1 0 0 1 1 1 1 LysM domain NAD_binding_10 PF13460.6 EXF85740.1 - 3.5e-07 30.3 0.1 6e-07 29.5 0.1 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EXF85740.1 - 2.5e-06 27.2 0.1 0.00055 19.5 0.1 2.2 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.24 EXF85740.1 - 5.9e-05 23.5 0.0 0.00019 21.8 0.0 1.9 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain 3Beta_HSD PF01073.19 EXF85740.1 - 0.00021 20.4 0.0 0.049 12.6 0.0 2.1 2 0 0 2 2 2 2 3-beta hydroxysteroid dehydrogenase/isomerase family Sacchrp_dh_NADP PF03435.18 EXF85740.1 - 0.00043 20.5 0.0 0.0019 18.5 0.0 1.9 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain NmrA PF05368.13 EXF85740.1 - 0.0048 16.5 0.0 0.0073 15.9 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family NAD_binding_4 PF07993.12 EXF85740.1 - 0.024 13.8 0.0 0.085 12.0 0.0 1.9 2 0 0 2 2 2 0 Male sterility protein GDP_Man_Dehyd PF16363.5 EXF85740.1 - 0.068 12.5 0.1 1.4 8.2 0.0 2.3 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase Bac_luciferase PF00296.20 EXF85741.1 - 1.6e-73 247.9 0.2 1.9e-73 247.7 0.2 1.0 1 0 0 1 1 1 1 Luciferase-like monooxygenase AP_endonuc_2 PF01261.24 EXF85741.1 - 0.079 12.4 0.0 4 6.8 0.0 2.4 2 0 0 2 2 2 0 Xylose isomerase-like TIM barrel NapD PF03927.13 EXF85742.1 - 0.057 13.5 0.1 0.11 12.6 0.1 1.4 1 0 0 1 1 1 0 NapD protein DUF2407_C PF13373.6 EXF85742.1 - 0.42 10.8 3.0 0.84 9.8 1.0 2.2 2 0 0 2 2 2 0 DUF2407 C-terminal domain Bestrophin PF01062.21 EXF85744.1 - 1.3e-35 123.2 0.2 2.2e-35 122.5 0.2 1.2 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel Glyco_hydro_3_C PF01915.22 EXF85746.1 - 5.8e-56 189.7 0.0 1.2e-55 188.6 0.0 1.6 2 0 0 2 2 2 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 EXF85746.1 - 1.6e-47 162.5 0.0 2.6e-47 161.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 EXF85746.1 - 8.2e-23 80.3 0.5 1.6e-22 79.4 0.5 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain PA14 PF07691.12 EXF85746.1 - 5.1e-05 23.1 0.0 9.4e-05 22.2 0.0 1.4 1 0 0 1 1 1 1 PA14 domain MFS_1 PF07690.16 EXF85748.1 - 5.1e-25 88.1 24.3 7.5e-25 87.6 24.3 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily RPE65 PF03055.15 EXF85749.1 - 3.6e-105 352.8 0.0 4.3e-105 352.6 0.0 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein OPT PF03169.15 EXF85750.1 - 3.1e-104 349.8 35.8 3.8e-104 349.5 35.8 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein CVNH PF08881.10 EXF85751.1 - 0.0022 18.7 0.0 0.013 16.2 0.0 1.9 1 1 1 2 2 2 2 CVNH domain CVNH PF08881.10 EXF85752.1 - 1.5e-05 25.6 0.1 2.3e-05 25.0 0.1 1.4 1 1 0 1 1 1 1 CVNH domain DUF732 PF05305.14 EXF85752.1 - 0.063 13.7 0.0 0.12 12.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF732) His_Phos_1 PF00300.22 EXF85753.1 - 3.7e-15 56.1 4.9 1.8e-10 40.8 4.1 3.4 2 1 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) ERCC4 PF02732.15 EXF85754.1 - 4.3e-30 105.0 0.0 7.4e-30 104.2 0.0 1.3 1 0 0 1 1 1 1 ERCC4 domain DDHD PF02862.17 EXF85754.1 - 0.079 13.1 2.3 0.12 12.5 1.5 1.8 2 0 0 2 2 2 0 DDHD domain CPSF100_C PF13299.6 EXF85754.1 - 0.53 10.4 12.4 0.1 12.8 8.3 1.8 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Asp-B-Hydro_N PF05279.11 EXF85754.1 - 0.77 9.8 10.5 1.6 8.8 10.5 1.4 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region SR-25 PF10500.9 EXF85754.1 - 1.5 8.3 24.7 0.12 12.0 14.2 2.4 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Tim54 PF11711.8 EXF85754.1 - 2.1 7.1 14.2 1.6 7.4 11.5 1.9 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 Dicty_REP PF05086.12 EXF85754.1 - 2.1 6.2 8.0 3.6 5.4 8.0 1.3 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF3464 PF11947.8 EXF85754.1 - 2.2 8.0 6.5 7.8 6.2 6.5 2.0 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Peptidase_S49_N PF08496.10 EXF85754.1 - 2.3 8.3 7.1 4.3 7.4 7.1 1.5 1 0 0 1 1 1 0 Peptidase family S49 N-terminal RR_TM4-6 PF06459.12 EXF85754.1 - 2.7 7.8 15.9 1.4 8.7 13.2 1.7 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Borrelia_P83 PF05262.11 EXF85754.1 - 4.2 5.7 13.8 5.9 5.3 13.8 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein Hid1 PF12722.7 EXF85754.1 - 5.5 5.0 7.3 8.2 4.4 7.3 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein NARP1 PF12569.8 EXF85754.1 - 7.7 5.3 14.2 12 4.6 14.2 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 DUF805 PF05656.14 EXF85755.1 - 9.2 6.7 13.9 2.7 8.4 6.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF805) Kinesin PF00225.23 EXF85757.1 - 1.4e-91 306.9 0.0 1.4e-91 306.9 0.0 3.2 2 1 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 EXF85757.1 - 1.9e-17 63.6 0.0 4e-14 52.8 0.0 3.6 2 1 0 3 3 3 2 Microtubule binding Spc7 PF08317.11 EXF85757.1 - 0.0017 17.3 17.3 0.0017 17.3 17.3 10.4 4 2 5 11 11 11 3 Spc7 kinetochore protein ABC_tran_Xtn PF12848.7 EXF85757.1 - 0.013 15.5 0.1 0.013 15.5 0.1 10.5 10 3 1 11 11 11 0 ABC transporter Fib_alpha PF08702.10 EXF85757.1 - 0.54 10.4 105.6 0.27 11.4 5.2 9.8 8 2 2 10 10 10 0 Fibrinogen alpha/beta chain family DNA_binding_1 PF01035.20 EXF85758.1 - 4.7e-25 87.5 0.0 5.7e-25 87.2 0.0 1.1 1 0 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, DNA binding domain Abhydrolase_3 PF07859.13 EXF85760.1 - 4.3e-39 134.6 0.0 5.1e-39 134.3 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 EXF85760.1 - 0.00028 19.9 1.1 0.0049 15.8 1.1 2.1 1 1 0 1 1 1 1 Carboxylesterase family Peptidase_S51 PF03575.17 EXF85760.1 - 0.12 12.0 0.0 0.17 11.5 0.0 1.2 1 0 0 1 1 1 0 Peptidase family S51 VIR_N PF15912.5 EXF85762.1 - 1.6 8.2 6.9 2.1 7.9 6.9 1.1 1 0 0 1 1 1 0 Virilizer, N-terminal FAP PF07174.11 EXF85762.1 - 2 7.8 16.5 3 7.2 16.5 1.2 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) Sulfate_transp PF00916.20 EXF85763.1 - 2.5e-112 375.4 18.8 3.1e-112 375.1 18.8 1.1 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 EXF85763.1 - 1.4e-07 31.2 0.0 2.5e-07 30.3 0.0 1.4 1 0 0 1 1 1 1 STAS domain MFS_MOT1 PF16983.5 EXF85763.1 - 1.9e-05 25.0 4.6 1.9e-05 25.0 4.6 3.3 2 2 0 2 2 2 2 Molybdate transporter of MFS superfamily YdjM PF04307.14 EXF85763.1 - 0.002 17.5 0.0 0.019 14.3 0.0 2.6 2 2 0 2 2 2 1 LexA-binding, inner membrane-associated putative hydrolase DUF917 PF06032.12 EXF85764.1 - 1.5e-118 395.7 2.9 2.7e-118 394.8 2.9 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF917) Hydantoinase_A PF01968.18 EXF85764.1 - 1.5e-33 116.3 2.4 1.2e-29 103.5 1.9 3.5 2 1 0 2 2 2 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.13 EXF85764.1 - 3.4e-30 105.0 1.1 2.7e-27 95.6 0.0 3.1 3 0 0 3 3 3 2 Hydantoinase/oxoprolinase N-terminal region MutL PF13941.6 EXF85764.1 - 8.5e-06 24.6 0.3 0.00056 18.6 0.0 2.5 2 0 0 2 2 2 1 MutL protein BcrAD_BadFG PF01869.20 EXF85764.1 - 0.00017 21.2 6.3 0.0022 17.6 0.0 3.9 2 1 0 2 2 2 1 BadF/BadG/BcrA/BcrD ATPase family ROK PF00480.20 EXF85764.1 - 0.00029 20.4 0.2 0.0028 17.2 0.1 2.7 3 0 0 3 3 3 1 ROK family FtsA PF14450.6 EXF85764.1 - 0.024 15.0 2.1 3.4 8.1 0.1 3.8 4 0 0 4 4 4 0 Cell division protein FtsA DUF1614 PF07758.11 EXF85764.1 - 0.025 14.6 0.0 0.06 13.3 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1614) StbA PF06406.11 EXF85764.1 - 0.03 13.6 0.0 1.8 7.8 0.0 2.3 2 0 0 2 2 2 0 StbA protein Glyco_hydro_92 PF07971.12 EXF85765.1 - 7.7e-141 470.2 0.0 9.7e-141 469.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 Glyco_hydro_92N PF17678.1 EXF85765.1 - 9.2e-60 202.5 0.7 1.4e-59 201.9 0.7 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 N-terminal domain GFA PF04828.14 EXF85766.1 - 3.7e-16 59.2 0.5 3.7e-16 59.2 0.5 1.3 2 0 0 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme Transpos_assoc PF13963.6 EXF85766.1 - 0.12 12.7 3.7 4.4 7.7 0.0 2.2 2 0 0 2 2 2 0 Transposase-associated domain zf-NADH-PPase PF09297.11 EXF85766.1 - 0.14 11.9 1.4 0.14 11.9 1.4 2.6 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain Myticin-prepro PF10690.9 EXF85766.1 - 0.96 9.7 5.2 0.22 11.8 0.6 1.9 1 1 1 2 2 2 0 Myticin pre-proprotein from the mussel Antimicrobial25 PF16839.5 EXF85766.1 - 2.2 8.4 10.8 14 5.9 0.2 2.2 2 0 0 2 2 2 0 Nematode antimicrobial peptide Sulfatase PF00884.23 EXF85767.1 - 1.7e-65 221.4 0.2 2.5e-65 220.9 0.2 1.3 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 EXF85767.1 - 0.022 14.3 0.7 1.1 8.7 0.1 2.2 2 0 0 2 2 2 0 Type I phosphodiesterase / nucleotide pyrophosphatase DUF4976 PF16347.5 EXF85767.1 - 0.033 14.5 0.0 0.1 12.9 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4976) Glyco_hydro_18 PF00704.28 EXF85768.1 - 9.4e-75 252.2 1.6 1.1e-74 252.0 1.6 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 PTS_2-RNA PF01885.16 EXF85770.1 - 4.3e-69 232.2 0.0 5.1e-69 231.9 0.0 1.0 1 0 0 1 1 1 1 RNA 2'-phosphotransferase, Tpt1 / KptA family Efg1 PF10153.9 EXF85772.1 - 1.4e-32 112.4 13.0 1.4e-32 112.4 13.0 3.0 4 0 0 4 4 4 1 rRNA-processing protein Efg1 FliG_N PF14842.6 EXF85772.1 - 0.016 15.7 0.9 0.033 14.7 0.9 1.5 1 0 0 1 1 1 0 FliG N-terminal domain DUF2813 PF11398.8 EXF85772.1 - 1.8 7.7 13.0 0.31 10.2 8.6 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2813) SNRNP27 PF08648.12 EXF85772.1 - 5.6 7.1 8.6 14 5.8 0.9 2.6 2 0 0 2 2 2 0 U4/U6.U5 small nuclear ribonucleoproteins His_Phos_1 PF00300.22 EXF85774.1 - 2.9e-20 72.8 0.0 8.8e-18 64.7 0.0 2.0 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) RabGAP-TBC PF00566.18 EXF85776.1 - 2.8e-26 92.5 0.1 6.9e-26 91.2 0.1 1.6 1 1 0 1 1 1 1 Rab-GTPase-TBC domain Lyase_1 PF00206.20 EXF85777.1 - 1.3e-21 77.3 0.2 1.9e-21 76.8 0.2 1.2 1 0 0 1 1 1 1 Lyase ADSL_C PF10397.9 EXF85777.1 - 1.8e-17 63.6 0.5 1.4e-16 60.8 0.0 2.7 3 0 0 3 3 3 1 Adenylosuccinate lyase C-terminus Pkinase PF00069.25 EXF85780.1 - 7e-57 192.8 0.0 1e-56 192.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF85780.1 - 1.2e-19 70.6 0.0 1.9e-19 69.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EXF85780.1 - 1.6e-06 27.7 0.0 1e-05 25.1 0.0 2.0 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 EXF85780.1 - 7.4e-05 21.9 0.0 0.00013 21.1 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EXF85780.1 - 0.0036 17.2 0.1 0.024 14.5 0.1 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.22 EXF85780.1 - 0.11 12.1 0.0 0.22 11.1 0.0 1.4 1 0 0 1 1 1 0 RIO1 family Pkinase_fungal PF17667.1 EXF85780.1 - 0.15 10.8 0.3 0.4 9.4 0.3 1.7 1 1 0 1 1 1 0 Fungal protein kinase F-box-like PF12937.7 EXF85781.1 - 7.3e-11 41.8 0.0 2.4e-10 40.1 0.0 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EXF85781.1 - 5.1e-09 35.8 0.0 2e-08 33.9 0.0 2.0 2 0 0 2 2 2 1 F-box domain LRR_6 PF13516.6 EXF85781.1 - 2.5e-08 33.3 0.6 0.091 12.9 0.0 5.8 7 0 0 7 7 7 2 Leucine Rich repeat LRR_4 PF12799.7 EXF85781.1 - 7.4e-05 23.0 6.5 0.16 12.4 0.0 4.6 4 2 0 4 4 4 2 Leucine Rich repeats (2 copies) PRANC PF09372.10 EXF85781.1 - 0.17 12.3 0.0 0.53 10.6 0.0 1.8 2 0 0 2 2 2 0 PRANC domain LRR_1 PF00560.33 EXF85781.1 - 9.2 7.3 9.4 85 4.3 0.1 5.6 8 0 0 8 8 8 0 Leucine Rich Repeat Iwr1 PF08574.10 EXF85782.1 - 1.5e-13 51.5 9.8 1.5e-13 51.5 9.8 3.3 2 1 1 3 3 3 1 Transcription factor Iwr1 AMPK1_CBM PF16561.5 EXF85783.1 - 1.4e-05 25.2 0.1 2.5e-05 24.4 0.1 1.4 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase HAMP PF00672.25 EXF85783.1 - 0.04 14.3 0.4 15 6.0 0.0 2.7 2 0 0 2 2 2 0 HAMP domain C1_2 PF03107.16 EXF85785.1 - 0.04 14.2 8.6 0.068 13.5 8.6 1.3 1 0 0 1 1 1 0 C1 domain zf-HIT PF04438.16 EXF85785.1 - 0.65 9.9 8.7 1.1 9.2 8.7 1.3 1 0 0 1 1 1 0 HIT zinc finger MFS_1 PF07690.16 EXF85786.1 - 4.4e-44 150.9 41.3 1.4e-43 149.2 41.3 1.8 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF85786.1 - 1.5e-16 60.4 5.6 1.5e-16 60.4 5.6 2.6 2 1 1 3 3 3 1 Sugar (and other) transporter Glucosamine_iso PF01182.20 EXF85787.1 - 1.2e-67 228.1 0.0 1.3e-67 228.0 0.0 1.0 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase Methyltransf_23 PF13489.6 EXF85788.1 - 2.8e-17 63.1 0.0 4e-17 62.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF85788.1 - 1e-08 35.1 0.0 0.001 18.9 0.0 2.5 3 0 0 3 3 3 2 Methyltransferase domain Methyltransf_25 PF13649.6 EXF85788.1 - 1.9e-08 34.9 0.0 4.8e-08 33.6 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF85788.1 - 8.9e-07 29.5 0.0 2.1e-06 28.3 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF85788.1 - 8.1e-05 23.3 0.0 0.00065 20.4 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EXF85788.1 - 0.0038 16.8 0.0 0.04 13.5 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase small domain Ubie_methyltran PF01209.18 EXF85788.1 - 0.0041 16.5 0.0 0.44 9.8 0.0 2.8 3 0 0 3 3 3 1 ubiE/COQ5 methyltransferase family PrmA PF06325.13 EXF85788.1 - 0.012 15.1 0.0 0.018 14.5 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) CMAS PF02353.20 EXF85788.1 - 0.013 14.8 0.0 0.068 12.5 0.0 1.8 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_4 PF02390.17 EXF85788.1 - 0.015 14.8 0.0 0.064 12.7 0.0 1.9 2 0 0 2 2 2 0 Putative methyltransferase FtsJ PF01728.19 EXF85788.1 - 0.079 13.1 0.0 0.12 12.4 0.0 1.2 1 0 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_3 PF01596.17 EXF85788.1 - 0.23 10.6 0.0 10 5.2 0.0 2.1 2 0 0 2 2 2 0 O-methyltransferase Dioxygenase_C PF00775.21 EXF85789.1 - 8.4e-45 152.4 0.0 2.1e-44 151.1 0.0 1.6 2 0 0 2 2 2 1 Dioxygenase Dioxygenase_N PF04444.14 EXF85789.1 - 4.7e-30 103.3 0.0 9.5e-30 102.3 0.0 1.5 1 0 0 1 1 1 1 Catechol dioxygenase N terminus SUI1 PF01253.22 EXF85789.1 - 1.4e-25 89.6 3.8 2.7e-25 88.7 3.8 1.4 1 0 0 1 1 1 1 Translation initiation factor SUI1 CarboxypepD_reg PF13620.6 EXF85789.1 - 0.17 12.2 0.0 0.48 10.7 0.0 1.8 1 1 0 1 1 1 0 Carboxypeptidase regulatory-like domain EOS1 PF12326.8 EXF85790.1 - 2.8e-15 56.7 4.8 6.2e-15 55.6 1.3 2.1 1 1 1 2 2 2 2 N-glycosylation protein MBA1 PF07961.11 EXF85791.1 - 9.9e-11 41.1 0.2 1.3e-10 40.7 0.2 1.1 1 0 0 1 1 1 1 MBA1-like protein Tim44 PF04280.15 EXF85791.1 - 7.7e-08 32.6 0.0 1.8e-07 31.4 0.0 1.5 1 1 0 1 1 1 1 Tim44-like domain SSF PF00474.17 EXF85792.1 - 8.8e-08 31.4 34.8 1.3e-06 27.5 34.8 2.2 1 1 0 1 1 1 1 Sodium:solute symporter family TMEM100 PF16311.5 EXF85792.1 - 0.57 9.8 2.5 3.3 7.3 0.0 3.0 2 1 1 3 3 3 0 Transmembrane protein 100 Sel1 PF08238.12 EXF85796.1 - 5.1e-49 163.6 23.3 9.7e-09 35.6 0.1 7.8 7 0 0 7 7 7 7 Sel1 repeat FIST_C PF10442.9 EXF85796.1 - 0.0067 16.4 0.1 0.017 15.1 0.0 1.6 2 0 0 2 2 2 1 FIST C domain CHASE3 PF05227.13 EXF85796.1 - 1.4 8.9 3.8 3.8 7.4 1.6 2.2 2 0 0 2 2 2 0 CHASE3 domain CBP4 PF07960.11 EXF85797.1 - 3.4e-28 98.1 1.1 4.4e-28 97.7 1.1 1.1 1 0 0 1 1 1 1 CBP4 COQ7 PF03232.13 EXF85797.1 - 0.011 15.6 0.0 0.013 15.3 0.0 1.1 1 0 0 1 1 1 0 Ubiquinone biosynthesis protein COQ7 DUF3854 PF12965.7 EXF85797.1 - 0.069 13.1 1.5 0.11 12.5 1.5 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3854) NAC PF01849.18 EXF85798.1 - 1.9e-24 85.4 0.3 8.3e-24 83.3 0.1 2.0 2 0 0 2 2 2 1 NAC domain A_deamin PF02137.18 EXF85799.1 - 9.6e-32 110.7 0.0 1.2e-31 110.4 0.0 1.1 1 0 0 1 1 1 1 Adenosine-deaminase (editase) domain Ribosomal_L24e PF01246.20 EXF85800.1 - 4.2e-28 97.4 0.1 4.2e-28 97.4 0.1 1.7 2 0 0 2 2 2 1 Ribosomal protein L24e Redoxin PF08534.10 EXF85801.1 - 1.3e-34 119.1 0.0 1.4e-34 118.9 0.0 1.0 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 EXF85801.1 - 9.3e-09 35.3 0.1 1.2e-08 34.9 0.1 1.1 1 0 0 1 1 1 1 AhpC/TSA family N6_Mtase PF02384.16 EXF85801.1 - 0.065 12.5 0.0 0.088 12.1 0.0 1.1 1 0 0 1 1 1 0 N-6 DNA Methylase FAM163 PF15069.6 EXF85801.1 - 0.15 12.5 0.0 0.2 12.1 0.0 1.2 1 0 0 1 1 1 0 FAM163 family DUF1348 PF07080.11 EXF85802.1 - 5e-64 214.1 9.9 5.9e-64 213.8 9.9 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1348) SnoaL_2 PF12680.7 EXF85802.1 - 5.6e-06 26.9 0.4 8.7e-06 26.3 0.4 1.3 1 0 0 1 1 1 1 SnoaL-like domain TAD2 PF18521.1 EXF85802.1 - 0.11 12.5 0.8 2.5 8.2 0.1 2.9 2 0 0 2 2 2 0 Transactivation domain 2 RGS PF00615.19 EXF85804.1 - 0.0001 22.5 0.3 0.027 14.8 0.0 2.3 2 0 0 2 2 2 2 Regulator of G protein signaling domain Pox_A14 PF05767.12 EXF85804.1 - 0.0044 17.1 0.1 0.01 16.0 0.1 1.6 1 0 0 1 1 1 1 Poxvirus virion envelope protein A14 Wzy_C PF04932.15 EXF85804.1 - 9.7 5.8 6.6 23 4.6 6.6 1.7 1 1 0 1 1 1 0 O-Antigen ligase CDC45 PF02724.14 EXF85805.1 - 0.00011 20.7 8.3 0.00014 20.4 8.3 1.1 1 0 0 1 1 1 1 CDC45-like protein Nop14 PF04147.12 EXF85805.1 - 0.00026 19.4 17.3 0.00032 19.1 17.3 1.1 1 0 0 1 1 1 1 Nop14-like family SAPS PF04499.15 EXF85805.1 - 0.0074 15.1 0.8 0.0078 15.1 0.8 1.2 1 0 0 1 1 1 1 SIT4 phosphatase-associated protein SDA1 PF05285.12 EXF85805.1 - 0.053 12.9 23.1 0.077 12.4 23.1 1.2 1 0 0 1 1 1 0 SDA1 RRN3 PF05327.11 EXF85805.1 - 0.11 11.0 15.9 0.15 10.6 15.9 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Mpp10 PF04006.12 EXF85805.1 - 0.3 9.5 20.3 0.41 9.0 20.3 1.1 1 0 0 1 1 1 0 Mpp10 protein DNA_pol_phi PF04931.13 EXF85805.1 - 0.37 8.8 35.6 0.51 8.4 35.6 1.1 1 0 0 1 1 1 0 DNA polymerase phi TFB6 PF17110.5 EXF85805.1 - 3.7 7.3 9.3 7.1 6.3 9.3 1.6 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH YL1 PF05764.13 EXF85805.1 - 3.8 7.6 26.2 6 6.9 26.2 1.3 1 0 0 1 1 1 0 YL1 nuclear protein BUD22 PF09073.10 EXF85805.1 - 6.5 6.0 23.5 8.9 5.5 23.5 1.1 1 0 0 1 1 1 0 BUD22 PPP4R2 PF09184.11 EXF85805.1 - 7.1 6.1 24.0 11 5.5 24.0 1.2 1 0 0 1 1 1 0 PPP4R2 ELP6 PF09807.9 EXF85808.1 - 2.1e-09 37.2 0.0 5.2e-09 35.9 0.0 1.6 1 1 0 1 1 1 1 Elongation complex protein 6 Ribosomal_L37e PF01907.19 EXF85809.1 - 1.9e-13 50.3 3.1 3.1e-13 49.7 3.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L37e Fez1 PF06818.15 EXF85810.1 - 0.0046 17.4 15.4 0.0046 17.4 15.4 2.0 2 0 0 2 2 2 1 Fez1 Csm2_III-A PF03750.13 EXF85810.1 - 0.0055 17.5 3.7 0.0066 17.3 2.1 2.0 1 1 1 2 2 1 1 Csm2 Type III-A CorA PF01544.18 EXF85810.1 - 0.012 15.0 3.2 0.019 14.3 3.2 1.3 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein OmpH PF03938.14 EXF85810.1 - 0.022 15.1 28.7 0.18 12.2 4.1 3.0 1 1 2 3 3 3 0 Outer membrane protein (OmpH-like) BLOC1_2 PF10046.9 EXF85810.1 - 0.032 14.5 4.4 0.032 14.5 4.4 3.3 4 1 0 4 4 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 NPV_P10 PF05531.12 EXF85810.1 - 0.06 13.8 4.8 0.22 12.0 0.2 2.6 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF4407 PF14362.6 EXF85810.1 - 0.074 12.4 18.1 0.27 10.5 17.8 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Cob_adeno_trans PF01923.18 EXF85810.1 - 0.076 13.1 0.6 0.076 13.1 0.6 2.8 2 1 1 3 3 3 0 Cobalamin adenosyltransferase AAA_13 PF13166.6 EXF85810.1 - 0.081 11.6 13.9 0.11 11.1 13.9 1.4 1 1 0 1 1 1 0 AAA domain PAXX PF15384.6 EXF85810.1 - 0.18 11.5 12.2 0.28 10.8 0.7 3.0 1 1 2 3 3 3 0 PAXX, PAralog of XRCC4 and XLF, also called C9orf142 Spc7 PF08317.11 EXF85810.1 - 0.24 10.2 27.5 0.078 11.8 7.1 2.5 2 1 0 3 3 3 0 Spc7 kinetochore protein GAS PF13851.6 EXF85810.1 - 0.27 10.6 27.4 0.44 9.9 7.7 3.3 3 1 0 3 3 3 0 Growth-arrest specific micro-tubule binding DASH_Dam1 PF08653.10 EXF85810.1 - 0.3 10.9 1.2 5.6 6.8 0.1 3.3 4 0 0 4 4 4 0 DASH complex subunit Dam1 DUF1664 PF07889.12 EXF85810.1 - 0.43 10.6 5.5 9.9 6.2 0.4 2.7 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) LMBR1 PF04791.16 EXF85810.1 - 0.54 9.1 4.3 0.59 9.0 4.3 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein MPS2 PF17060.5 EXF85810.1 - 0.93 8.7 12.4 0.59 9.3 9.7 1.9 1 1 0 2 2 2 0 Monopolar spindle protein 2 FAM76 PF16046.5 EXF85810.1 - 1.1 8.5 14.3 0.36 10.1 3.6 2.1 2 0 0 2 2 2 0 FAM76 protein IFT20 PF14931.6 EXF85810.1 - 1.4 9.1 15.4 0.26 11.5 6.8 2.8 2 1 1 3 3 3 0 Intraflagellar transport complex B, subunit 20 YlqD PF11068.8 EXF85810.1 - 1.6 9.1 19.3 0.99 9.8 5.2 3.0 3 0 0 3 3 3 0 YlqD protein Laminin_II PF06009.12 EXF85810.1 - 1.7 8.6 16.0 0.18 11.8 2.4 3.1 3 0 0 3 3 3 0 Laminin Domain II DUF948 PF06103.11 EXF85810.1 - 2.1 8.6 5.7 1.3 9.3 1.7 2.3 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Allexi_40kDa PF05549.11 EXF85810.1 - 2.2 7.7 5.3 0.86 9.1 1.5 2.0 2 0 0 2 2 2 0 Allexivirus 40kDa protein PEARLI-4 PF05278.12 EXF85810.1 - 2.6 7.5 14.2 0.45 10.1 3.6 2.3 2 0 0 2 2 2 0 Arabidopsis phospholipase-like protein (PEARLI 4) TMF_DNA_bd PF12329.8 EXF85810.1 - 2.8 8.0 26.9 5.9 7.0 5.8 3.9 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding FapA PF03961.13 EXF85810.1 - 4 5.9 11.5 0.37 9.3 4.8 2.0 1 1 2 3 3 3 0 Flagellar Assembly Protein A Cnn_1N PF07989.11 EXF85810.1 - 5.5 7.2 19.8 0.51 10.5 0.8 3.5 3 1 0 3 3 3 0 Centrosomin N-terminal motif 1 ADIP PF11559.8 EXF85810.1 - 6.5 6.8 22.2 2.2 8.3 6.5 2.9 3 0 0 3 3 3 0 Afadin- and alpha -actinin-Binding Fungal_trans PF04082.18 EXF85812.1 - 1e-13 51.0 1.7 2.6e-13 49.6 0.2 2.3 2 1 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF85812.1 - 2e-09 37.4 11.1 3.7e-09 36.6 11.1 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Mito_carr PF00153.27 EXF85815.1 - 4.4e-71 234.9 3.1 8.5e-24 83.3 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 EXF85815.1 - 0.32 10.1 5.5 7.1 5.7 0.1 3.8 1 1 4 5 5 5 0 Gammaproteobacterial serine protease Zn_clus PF00172.18 EXF85816.1 - 0.011 15.8 10.6 0.019 15.1 10.6 1.3 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain LSM PF01423.22 EXF85817.1 - 1.3e-15 56.9 0.2 1.8e-15 56.3 0.2 1.3 1 0 0 1 1 1 1 LSM domain DUF150_C PF17384.2 EXF85817.1 - 0.093 12.9 0.0 0.14 12.3 0.0 1.2 1 0 0 1 1 1 0 RimP C-terminal SH3 domain FoP_duplication PF13865.6 EXF85817.1 - 1.9 9.1 24.7 3.3 8.3 24.6 1.5 1 1 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 Pan3_PK PF18101.1 EXF85818.1 - 2e-63 212.5 0.1 3e-63 211.9 0.1 1.3 1 0 0 1 1 1 1 Pan3 Pseudokinase domain Pkinase PF00069.25 EXF85818.1 - 5.1e-05 22.8 0.0 8.9e-05 22.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF85818.1 - 0.19 11.0 0.0 0.31 10.3 0.0 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase UBA_4 PF14555.6 EXF85819.1 - 1.5e-10 40.7 0.0 2.9e-10 39.8 0.0 1.5 1 0 0 1 1 1 1 UBA-like domain UBX PF00789.20 EXF85819.1 - 1.3e-06 28.5 0.0 6e-06 26.4 0.0 2.2 2 1 0 2 2 2 1 UBX domain SUB1_ProdP9 PF18213.1 EXF85819.1 - 0.0023 17.8 0.0 0.0068 16.2 0.0 1.7 1 0 0 1 1 1 1 SUB1 protease Prodomain ProdP9 DUF612 PF04747.12 EXF85819.1 - 0.1 11.7 10.6 0.16 11.1 10.6 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF612 GAT PF03127.14 EXF85821.1 - 7.7e-20 71.0 1.9 1.5e-18 66.9 0.5 2.5 2 1 0 2 2 2 1 GAT domain VHS PF00790.19 EXF85821.1 - 0.00084 19.2 0.0 0.0025 17.7 0.0 1.8 2 0 0 2 2 2 1 VHS domain HET PF06985.11 EXF85822.1 - 4.1e-11 43.4 0.0 8.7e-11 42.4 0.0 1.6 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) UIM PF02809.20 EXF85822.1 - 0.00071 19.3 5.4 2.7 8.1 0.1 4.0 3 0 0 3 3 3 3 Ubiquitin interaction motif F-box PF00646.33 EXF85824.1 - 0.002 17.9 0.1 0.012 15.4 0.1 2.4 1 0 0 1 1 1 1 F-box domain Peptidase_S74 PF13884.6 EXF85824.1 - 0.19 12.1 0.1 12 6.3 0.0 2.8 2 0 0 2 2 2 0 Chaperone of endosialidase Histone_H2A_C PF16211.5 EXF85825.1 - 2.2e-21 75.3 3.1 3.8e-21 74.5 3.1 1.4 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 EXF85825.1 - 6.8e-17 62.1 0.0 9.3e-17 61.6 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EXF85825.1 - 1e-05 25.7 0.0 1.4e-05 25.3 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Complex1_LYR PF05347.15 EXF85826.1 - 7.8e-10 38.7 1.8 1.2e-09 38.0 1.8 1.3 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Ribosomal_S4e PF00900.20 EXF85827.1 - 7.5e-36 121.9 0.3 1.9e-35 120.6 0.1 1.8 2 0 0 2 2 2 1 Ribosomal family S4e 40S_S4_C PF16121.5 EXF85827.1 - 1.9e-24 85.0 0.1 3.7e-24 84.1 0.1 1.5 1 0 0 1 1 1 1 40S ribosomal protein S4 C-terminus RS4NT PF08071.12 EXF85827.1 - 9.8e-18 64.0 4.9 1.9e-17 63.1 4.9 1.5 1 0 0 1 1 1 1 RS4NT (NUC023) domain KOW PF00467.29 EXF85827.1 - 1.4e-05 24.8 1.8 1.4e-05 24.8 1.8 3.0 3 0 0 3 3 3 1 KOW motif S4 PF01479.25 EXF85827.1 - 2.2e-05 24.0 0.0 5.1e-05 22.9 0.0 1.6 1 0 0 1 1 1 1 S4 domain Myb_DNA-binding PF00249.31 EXF85828.1 - 1e-14 54.4 0.0 4.6e-07 29.9 0.0 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EXF85828.1 - 1.2e-09 38.2 0.0 0.00066 19.9 0.0 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain SLIDE PF09111.10 EXF85828.1 - 6.8e-05 22.9 0.8 0.15 12.1 0.0 2.6 3 0 0 3 3 3 2 SLIDE CHDCT2 PF08074.11 EXF85828.1 - 0.037 14.2 0.0 0.2 11.9 0.0 2.1 2 0 0 2 2 2 0 CHDCT2 (NUC038) domain SANT_DAMP1_like PF16282.5 EXF85828.1 - 0.11 12.7 0.0 0.27 11.5 0.0 1.6 1 0 0 1 1 1 0 SANT/Myb-like domain of DAMP1 Septin PF00735.18 EXF85831.1 - 6e-33 114.3 0.0 2.3e-11 43.5 0.0 3.2 3 0 0 3 3 3 3 Septin AAA_16 PF13191.6 EXF85831.1 - 0.0077 16.6 0.1 0.033 14.6 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain AAA_23 PF13476.6 EXF85831.1 - 0.0082 16.7 0.2 0.025 15.1 0.0 1.9 2 0 0 2 2 2 1 AAA domain FtsK_SpoIIIE PF01580.18 EXF85831.1 - 0.07 12.5 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family ABC1 PF03109.16 EXF85833.1 - 6.5e-22 77.9 0.0 1.6e-21 76.7 0.0 1.6 1 0 0 1 1 1 1 ABC1 family APH PF01636.23 EXF85833.1 - 2.5e-05 24.3 0.0 5.4e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family SUR7 PF06687.12 EXF85834.1 - 1.8e-25 89.8 8.3 2.4e-25 89.4 8.3 1.1 1 0 0 1 1 1 1 SUR7/PalI family 7TM_GPCR_Srd PF10317.9 EXF85834.1 - 0.92 8.6 7.4 0.86 8.7 6.3 1.4 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srd Adaptin_N PF01602.20 EXF85836.1 - 4.9e-115 385.1 0.8 6.2e-115 384.7 0.8 1.1 1 0 0 1 1 1 1 Adaptin N terminal region COP-gamma_platf PF08752.10 EXF85836.1 - 9.5e-55 184.9 5.9 2.3e-54 183.7 5.9 1.7 1 0 0 1 1 1 1 Coatomer gamma subunit appendage platform subdomain Coatomer_g_Cpla PF16381.5 EXF85836.1 - 3.1e-37 127.2 0.2 9e-37 125.7 0.2 1.9 1 0 0 1 1 1 1 Coatomer subunit gamma-1 C-terminal appendage platform HEAT_2 PF13646.6 EXF85836.1 - 6.7e-18 64.9 0.9 3.4e-12 46.6 0.0 5.1 2 1 3 5 5 5 1 HEAT repeats Cnd1 PF12717.7 EXF85836.1 - 3.3e-07 30.5 9.4 0.026 14.6 0.1 4.9 4 1 1 5 5 5 2 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.8 EXF85836.1 - 0.0017 18.0 6.1 0.0038 16.8 0.2 3.2 4 0 0 4 4 4 1 CLASP N terminal HEAT_PBS PF03130.16 EXF85836.1 - 0.0022 18.5 0.1 1.5 9.7 0.0 4.0 3 0 0 3 3 3 1 PBS lyase HEAT-like repeat HEAT PF02985.22 EXF85836.1 - 0.025 14.8 6.6 2.2 8.8 0.2 5.4 5 0 0 5 5 5 0 HEAT repeat Coatomer_b_Cpla PF14806.6 EXF85836.1 - 0.048 13.6 0.0 0.29 11.1 0.0 2.2 2 0 0 2 2 2 0 Coatomer beta subunit appendage platform RTP1_C1 PF10363.9 EXF85836.1 - 0.07 13.3 0.6 4.3 7.6 0.0 3.5 3 0 0 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 DUF5010 PF16402.5 EXF85836.1 - 0.071 11.9 0.0 0.15 10.8 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5010) HEAT_EZ PF13513.6 EXF85836.1 - 1.6 9.3 4.5 1.5 9.5 0.6 3.0 3 0 0 3 3 3 0 HEAT-like repeat CDP-OH_P_transf PF01066.21 EXF85837.1 - 9.1e-17 61.6 0.1 9.1e-17 61.6 0.1 3.4 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase bZIP_1 PF00170.21 EXF85838.1 - 8.6e-08 32.2 16.4 1.9e-07 31.0 16.4 1.6 1 0 0 1 1 1 1 bZIP transcription factor PAP1 PF08601.10 EXF85838.1 - 4e-06 26.8 16.1 9.4e-05 22.3 0.0 2.3 1 1 1 2 2 2 1 Transcription factor PAP1 V_ATPase_I PF01496.19 EXF85838.1 - 0.0014 16.7 3.2 0.0017 16.4 3.2 1.1 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family TFIIA PF03153.13 EXF85838.1 - 0.015 15.3 9.5 0.016 15.3 9.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SHE3 PF17078.5 EXF85838.1 - 0.018 14.7 10.5 0.027 14.2 9.1 1.7 1 1 1 2 2 2 0 SWI5-dependent HO expression protein 3 ADIP PF11559.8 EXF85838.1 - 0.04 14.0 12.2 0.071 13.2 12.2 1.4 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding DUF641 PF04859.12 EXF85838.1 - 0.044 14.1 6.1 0.069 13.5 6.1 1.3 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) bZIP_Maf PF03131.17 EXF85838.1 - 0.05 14.1 15.6 0.05 14.1 14.5 1.6 1 1 0 1 1 1 0 bZIP Maf transcription factor DivIC PF04977.15 EXF85838.1 - 0.056 13.2 4.7 0.14 11.9 4.7 1.7 1 0 0 1 1 1 0 Septum formation initiator FlaC_arch PF05377.11 EXF85838.1 - 0.37 11.2 2.2 0.82 10.1 2.2 1.6 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) bZIP_2 PF07716.15 EXF85838.1 - 0.37 10.9 19.5 1.3 9.2 17.8 2.2 1 1 1 2 2 2 0 Basic region leucine zipper GvpL_GvpF PF06386.11 EXF85838.1 - 0.92 9.4 8.9 1.4 8.8 8.9 1.2 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF YabA PF06156.13 EXF85838.1 - 1.3 9.7 5.8 0.91 10.2 3.6 1.7 1 1 1 2 2 2 0 Initiation control protein YabA UPF0242 PF06785.11 EXF85838.1 - 1.5 8.8 7.3 2.3 8.3 7.3 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Mrr_cat PF04471.12 EXF85839.1 - 0.025 14.6 2.0 0.057 13.4 2.0 1.6 1 0 0 1 1 1 0 Restriction endonuclease Trp_DMAT PF11991.8 EXF85840.1 - 3.4e-110 368.9 0.0 4.5e-110 368.5 0.0 1.1 1 0 0 1 1 1 1 Tryptophan dimethylallyltransferase OAF PF14941.6 EXF85840.1 - 0.22 11.0 0.0 0.36 10.2 0.0 1.2 1 0 0 1 1 1 0 Transcriptional regulator, Out at first Abhydrolase_9_N PF15420.6 EXF85841.1 - 0.06 13.3 0.4 0.1 12.6 0.4 1.3 1 0 0 1 1 1 0 Alpha/beta-hydrolase family N-terminus CbtA PF09490.10 EXF85841.1 - 0.079 12.7 0.7 2.8 7.7 0.0 2.3 2 0 0 2 2 2 0 Probable cobalt transporter subunit (CbtA) SUIM_assoc PF16619.5 EXF85842.1 - 3.9 7.6 9.8 0.7 10.0 2.1 2.5 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Kinesin PF00225.23 EXF85843.1 - 4.4e-117 390.7 0.0 6e-117 390.3 0.0 1.2 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EXF85843.1 - 9.5e-29 100.3 0.0 2e-28 99.2 0.0 1.6 1 0 0 1 1 1 1 Microtubule binding Herpes_UL14 PF03580.14 EXF85843.1 - 0.017 15.3 2.5 0.051 13.8 2.5 1.8 1 0 0 1 1 1 0 Herpesvirus UL14-like protein Glyco_hydro_115 PF15979.5 EXF85844.1 - 8.9e-134 446.2 1.2 1.5e-133 445.4 1.2 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 115 GH115_C PF17829.1 EXF85844.1 - 3.4e-50 170.2 0.8 4.7e-50 169.8 0.1 1.6 2 0 0 2 2 2 1 Gylcosyl hydrolase family 115 C-terminal domain Glyco_hydro_67N PF03648.14 EXF85844.1 - 0.14 12.5 0.0 0.71 10.2 0.0 2.2 2 0 0 2 2 2 0 Glycosyl hydrolase family 67 N-terminus HET PF06985.11 EXF85845.1 - 4e-10 40.2 8.7 3.5e-08 33.9 3.8 2.6 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) zf-C2H2_4 PF13894.6 EXF85845.1 - 1.2e-05 25.7 6.3 0.042 14.7 0.1 3.7 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2 PF00096.26 EXF85845.1 - 7e-05 23.1 7.3 0.11 12.9 0.1 3.9 3 0 0 3 3 3 2 Zinc finger, C2H2 type Axin_b-cat_bind PF08833.10 EXF85845.1 - 0.065 13.4 0.1 0.17 12.0 0.1 1.7 1 0 0 1 1 1 0 Axin beta-catenin binding domain F-box-like PF12937.7 EXF85846.1 - 0.00039 20.2 1.1 0.0013 18.6 1.1 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EXF85846.1 - 0.013 15.4 0.4 0.039 13.8 0.4 1.8 1 0 0 1 1 1 0 F-box domain UQ_con PF00179.26 EXF85848.1 - 6.1e-10 38.9 0.0 1.2e-09 37.9 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme TRCF PF03461.15 EXF85848.1 - 0.0065 16.8 0.0 0.014 15.8 0.0 1.5 1 0 0 1 1 1 1 TRCF domain F-box PF00646.33 EXF85848.1 - 0.025 14.5 0.4 0.062 13.2 0.4 1.6 1 0 0 1 1 1 0 F-box domain F-box-like PF12937.7 EXF85848.1 - 0.061 13.2 0.4 0.15 12.0 0.4 1.6 1 0 0 1 1 1 0 F-box-like DUF3844 PF12955.7 EXF85851.1 - 1.9e-35 121.2 3.4 1.9e-35 121.2 3.4 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF3844) hNIFK_binding PF12196.8 EXF85852.1 - 0.023 14.2 4.2 0.69 9.5 0.2 3.7 3 0 0 3 3 3 0 FHA Ki67 binding domain of hNIFK TMF_TATA_bd PF12325.8 EXF85852.1 - 0.027 14.7 0.5 0.027 14.7 0.5 2.8 3 0 0 3 3 3 0 TATA element modulatory factor 1 TATA binding YabA PF06156.13 EXF85852.1 - 0.21 12.2 3.6 0.53 10.9 0.2 2.7 2 1 1 3 3 3 0 Initiation control protein YabA LSM PF01423.22 EXF85853.1 - 5.4e-21 74.0 0.6 6.1e-21 73.9 0.6 1.0 1 0 0 1 1 1 1 LSM domain Rhodanese PF00581.20 EXF85854.1 - 9.6e-09 35.7 0.0 1.2e-08 35.4 0.0 1.2 1 0 0 1 1 1 1 Rhodanese-like domain Amino_oxidase PF01593.24 EXF85855.1 - 1.1e-61 209.5 0.0 1.6e-61 209.0 0.0 1.2 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EXF85855.1 - 3.5e-08 33.6 0.3 1.2e-07 31.8 0.0 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EXF85855.1 - 8.8e-05 22.2 0.0 0.00048 19.8 0.0 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EXF85855.1 - 0.00079 18.6 0.0 0.0012 18.0 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EXF85855.1 - 0.0066 15.7 0.0 0.034 13.4 0.1 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EXF85855.1 - 0.021 14.1 0.4 0.04 13.2 0.4 1.4 1 0 0 1 1 1 0 FAD binding domain HI0933_like PF03486.14 EXF85855.1 - 0.023 13.4 0.0 0.042 12.5 0.0 1.4 1 0 0 1 1 1 0 HI0933-like protein Pyr_redox_3 PF13738.6 EXF85855.1 - 0.069 12.4 0.3 0.14 11.4 0.3 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EXF85855.1 - 0.13 11.4 0.1 0.23 10.6 0.1 1.3 1 0 0 1 1 1 0 Thi4 family DAO PF01266.24 EXF85856.1 - 4.3e-52 177.8 0.3 5e-52 177.6 0.3 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EXF85856.1 - 0.00021 21.5 0.1 0.00076 19.7 0.1 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 EXF85856.1 - 0.00041 19.7 0.0 0.048 12.9 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EXF85856.1 - 0.00067 19.0 0.0 0.0011 18.3 0.0 1.2 1 0 0 1 1 1 1 Thi4 family Pyr_redox_2 PF07992.14 EXF85856.1 - 0.00071 18.9 0.0 0.018 14.3 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EXF85856.1 - 0.002 18.1 0.1 0.05 13.6 0.0 2.2 2 0 0 2 2 2 1 FAD-NAD(P)-binding Amino_oxidase PF01593.24 EXF85856.1 - 0.033 13.5 0.0 0.14 11.5 0.0 1.9 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase HI0933_like PF03486.14 EXF85856.1 - 0.045 12.5 0.0 0.52 9.0 0.0 2.0 2 0 0 2 2 2 0 HI0933-like protein Pyr_redox PF00070.27 EXF85856.1 - 0.096 13.3 0.0 3.6 8.2 0.0 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Globin PF00042.22 EXF85857.1 - 5.1e-07 30.2 0.0 9.3e-07 29.4 0.0 1.5 1 0 0 1 1 1 1 Globin NAD_binding_1 PF00175.21 EXF85857.1 - 1.6e-05 25.5 0.0 4.8e-05 24.0 0.0 1.9 1 1 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 EXF85857.1 - 6.8e-05 23.1 0.0 0.00011 22.4 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 EXF85857.1 - 0.0083 16.3 0.1 0.032 14.3 0.0 2.0 3 0 0 3 3 3 1 Ferric reductase NAD binding domain Protoglobin PF11563.8 EXF85857.1 - 0.15 11.9 0.0 0.29 11.0 0.0 1.5 1 1 0 1 1 1 0 Protoglobin GLEYA PF10528.9 EXF85858.1 - 2.8e-38 130.2 11.9 2.9e-23 82.1 5.5 2.7 2 0 0 2 2 2 2 GLEYA domain PA14 PF07691.12 EXF85858.1 - 1.6e-18 66.9 0.1 8.5e-09 35.4 0.1 2.5 2 0 0 2 2 2 2 PA14 domain Candida_ALS PF05792.13 EXF85858.1 - 8.4e-05 23.1 2.7 8.4e-05 23.1 2.7 40.9 39 5 2 41 41 41 1 Candida agglutinin-like (ALS) FAD_binding_3 PF01494.19 EXF85859.1 - 8.1e-19 68.1 0.8 6.3e-14 52.0 0.0 2.1 2 0 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 EXF85859.1 - 1.7e-05 25.0 1.1 4.2e-05 23.7 1.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EXF85859.1 - 0.0002 20.7 2.1 0.00072 18.9 2.1 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EXF85859.1 - 0.00062 19.4 1.9 0.0023 17.6 0.9 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EXF85859.1 - 0.00084 18.5 2.3 0.0014 17.8 2.3 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.27 EXF85859.1 - 0.003 18.1 0.4 0.0088 16.6 0.4 1.9 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 EXF85859.1 - 0.02 14.2 1.9 0.039 13.2 0.3 2.1 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase AlaDh_PNT_C PF01262.21 EXF85859.1 - 0.021 14.1 0.4 0.021 14.1 0.4 1.9 3 0 0 3 3 3 0 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.22 EXF85859.1 - 0.029 13.5 0.8 0.029 13.5 0.8 1.5 2 0 0 2 2 2 0 Glucose inhibited division protein A Trp_halogenase PF04820.14 EXF85859.1 - 0.029 13.2 0.8 0.16 10.8 0.7 2.0 2 0 0 2 2 2 0 Tryptophan halogenase FAD_oxidored PF12831.7 EXF85859.1 - 0.039 13.3 1.1 0.078 12.3 1.1 1.5 1 0 0 1 1 1 0 FAD dependent oxidoreductase HI0933_like PF03486.14 EXF85859.1 - 0.064 12.0 0.6 0.13 10.9 0.6 1.5 1 0 0 1 1 1 0 HI0933-like protein ApbA PF02558.16 EXF85859.1 - 0.12 12.0 0.8 0.24 11.0 0.8 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA MFS_1 PF07690.16 EXF85860.1 - 1.9e-24 86.3 40.7 2.1e-22 79.6 37.6 2.5 2 1 0 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EXF85860.1 - 9.7e-23 80.4 22.9 1.4e-22 79.9 22.9 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) PIRT PF15099.6 EXF85860.1 - 0.39 10.3 2.7 16 5.1 0.0 2.6 2 0 0 2 2 2 0 Phosphoinositide-interacting protein family B12D PF06522.11 EXF85860.1 - 8.5 6.3 8.4 1.9 8.3 0.5 3.8 3 0 0 3 3 3 0 NADH-ubiquinone reductase complex 1 MLRQ subunit adh_short PF00106.25 EXF85862.1 - 4.2e-17 62.3 0.2 1.8e-16 60.2 0.2 1.8 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF85862.1 - 3.4e-13 49.7 0.6 2.7e-12 46.8 0.6 2.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Leucyl-specific PF14795.6 EXF85862.1 - 0.039 14.0 0.0 1.6 8.8 0.1 2.4 2 0 0 2 2 2 0 Leucine-tRNA synthetase-specific domain Lon_C PF05362.13 EXF85862.1 - 0.067 12.7 0.7 0.14 11.7 0.3 1.6 2 0 0 2 2 2 0 Lon protease (S16) C-terminal proteolytic domain NADHdh PF00146.21 EXF85862.1 - 0.22 10.8 0.0 0.29 10.4 0.0 1.1 1 0 0 1 1 1 0 NADH dehydrogenase p450 PF00067.22 EXF85863.1 - 1.8e-54 185.2 0.0 2.2e-54 184.9 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 adh_short_C2 PF13561.6 EXF85864.1 - 6.7e-35 120.7 1.6 1.2e-31 110.1 0.1 2.5 2 1 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF85864.1 - 6.6e-34 117.1 1.3 1.1e-24 87.0 0.0 2.4 2 0 0 2 2 2 2 short chain dehydrogenase KR PF08659.10 EXF85864.1 - 0.021 14.7 2.3 0.021 14.7 2.3 2.4 2 1 0 2 2 2 0 KR domain Epimerase PF01370.21 EXF85864.1 - 0.1 12.0 0.1 4.1 6.8 0.0 2.4 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family ADH_zinc_N PF00107.26 EXF85864.1 - 0.16 12.0 0.8 0.54 10.2 0.8 2.0 1 1 0 1 1 1 0 Zinc-binding dehydrogenase Pyr_redox PF00070.27 EXF85864.1 - 0.17 12.5 0.7 0.39 11.3 0.7 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase p450 PF00067.22 EXF85865.1 - 1.7e-52 178.7 0.0 2.3e-52 178.3 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 Clathrin PF00637.20 EXF85866.1 - 1.6e-23 83.2 4.8 9.8e-23 80.6 1.1 2.7 3 0 0 3 3 3 1 Region in Clathrin and VPS VPS11_C PF12451.8 EXF85866.1 - 1.2e-19 70.3 0.0 2.8e-19 69.0 0.0 1.7 1 0 0 1 1 1 1 Vacuolar protein sorting protein 11 C terminal zf-C3H2C3 PF17122.5 EXF85866.1 - 3.2e-08 33.5 7.6 7.7e-08 32.2 7.6 1.7 1 0 0 1 1 1 1 Zinc-finger zf-C3HC4_2 PF13923.6 EXF85866.1 - 5e-06 26.3 8.4 1.2e-05 25.0 8.4 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EXF85866.1 - 0.00061 20.1 7.7 0.0018 18.6 7.7 1.9 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 EXF85866.1 - 0.0038 17.1 7.1 0.0086 16.0 7.1 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EXF85866.1 - 0.012 15.6 4.3 0.036 14.1 4.3 1.8 1 0 0 1 1 1 0 RING-type zinc-finger CheF-arch PF04283.12 EXF85866.1 - 0.036 13.8 0.1 0.08 12.7 0.1 1.5 1 0 0 1 1 1 0 Chemotaxis signal transduction system protein F from archaea TPR_11 PF13414.6 EXF85866.1 - 0.13 12.0 0.1 0.66 9.7 0.1 2.3 2 0 0 2 2 2 0 TPR repeat TFIIS_C PF01096.18 EXF85866.1 - 0.15 11.9 0.6 14 5.6 0.1 2.5 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) zf-ANAPC11 PF12861.7 EXF85866.1 - 0.2 11.7 1.6 0.58 10.3 1.6 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.5 EXF85866.1 - 0.3 10.9 3.8 0.94 9.3 3.8 1.9 1 0 0 1 1 1 0 RING-like zinc finger zf-rbx1 PF12678.7 EXF85866.1 - 0.45 10.8 6.6 1.2 9.5 6.6 1.7 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 EXF85866.1 - 3.1 7.7 11.8 0.69 9.8 7.5 2.1 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Pkinase PF00069.25 EXF85867.1 - 8.3e-51 172.9 0.1 7.1e-34 117.4 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EXF85867.1 - 1.1e-21 77.3 1.5 6.3e-20 71.5 0.9 3.3 2 1 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 EXF85867.1 - 0.00076 18.9 0.0 0.0028 17.0 0.0 1.8 1 1 0 1 1 1 1 Kinase-like APH PF01636.23 EXF85867.1 - 0.0041 17.1 0.5 0.03 14.2 0.0 2.4 2 1 0 2 2 2 1 Phosphotransferase enzyme family SAP30_Sin3_bdg PF13867.6 EXF85869.1 - 1.7e-09 37.8 2.2 3.5e-08 33.7 0.3 2.4 2 0 0 2 2 2 2 Sin3 binding region of histone deacetylase complex subunit SAP30 DnaJ_C PF01556.18 EXF85870.1 - 1.6e-38 132.1 0.0 2.4e-38 131.6 0.0 1.3 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EXF85870.1 - 1.4e-23 82.7 0.7 2.7e-23 81.9 0.7 1.5 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 EXF85870.1 - 1.2e-09 38.4 21.5 2.5e-09 37.4 21.5 1.6 1 0 0 1 1 1 1 DnaJ central domain HypA PF01155.19 EXF85870.1 - 5 7.2 7.3 35 4.5 7.5 2.2 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Anti-TRAP PF15777.5 EXF85870.1 - 6.3 6.8 17.6 1.1 9.3 2.7 3.1 2 1 0 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein BRO1 PF03097.18 EXF85871.1 - 1.2e-131 439.1 0.7 1.2e-131 439.1 0.7 2.2 3 0 0 3 3 3 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.6 EXF85871.1 - 5.2e-80 268.9 18.9 9.8e-80 268.0 18.9 1.5 1 0 0 1 1 1 1 ALIX V-shaped domain binding to HIV COG2 PF06148.11 EXF85871.1 - 7.9 6.6 12.3 0.31 11.1 1.5 3.4 3 0 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 Ank_2 PF12796.7 EXF85873.1 - 1.3e-26 93.0 0.1 4.9e-10 39.8 0.0 4.3 2 2 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EXF85873.1 - 9.2e-25 86.7 0.4 7.8e-05 23.2 0.0 7.2 5 1 2 7 7 7 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EXF85873.1 - 4.6e-15 54.2 3.4 0.077 13.6 0.1 7.9 9 0 0 9 9 9 3 Ankyrin repeat Ank_5 PF13857.6 EXF85873.1 - 3.4e-12 46.3 3.1 0.059 13.7 0.0 6.0 4 1 2 6 6 6 4 Ankyrin repeats (many copies) Ank PF00023.30 EXF85873.1 - 6.1e-12 45.4 5.0 0.027 14.9 0.1 7.4 8 0 0 8 8 8 3 Ankyrin repeat NACHT PF05729.12 EXF85873.1 - 1.6e-05 24.9 0.1 4e-05 23.6 0.1 1.6 1 0 0 1 1 1 1 NACHT domain KAP_NTPase PF07693.14 EXF85873.1 - 0.0052 16.1 0.1 0.0088 15.3 0.1 1.3 1 0 0 1 1 1 1 KAP family P-loop domain DUF2116 PF09889.9 EXF85874.1 - 0.18 11.8 1.3 0.33 11.0 1.3 1.3 1 0 0 1 1 1 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) FMN_dh PF01070.18 EXF85875.1 - 6.5e-120 400.3 0.1 8e-120 400.0 0.1 1.1 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.28 EXF85875.1 - 3.3e-22 78.4 0.1 6.7e-22 77.4 0.1 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Glu_synthase PF01645.17 EXF85875.1 - 3.3e-07 29.8 0.1 6.4e-07 28.8 0.1 1.4 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.25 EXF85875.1 - 0.00027 20.0 2.5 0.00088 18.4 0.2 2.3 3 0 0 3 3 3 1 IMP dehydrogenase / GMP reductase domain NMO PF03060.15 EXF85875.1 - 0.0022 17.4 0.5 0.0038 16.6 0.5 1.3 1 0 0 1 1 1 1 Nitronate monooxygenase His_biosynth PF00977.21 EXF85875.1 - 0.014 14.9 1.4 0.53 9.7 0.1 2.3 1 1 0 2 2 2 0 Histidine biosynthesis protein G3P_antiterm PF04309.12 EXF85875.1 - 0.029 13.8 0.1 0.27 10.6 0.0 2.1 2 0 0 2 2 2 0 Glycerol-3-phosphate responsive antiterminator ThiG PF05690.14 EXF85875.1 - 0.061 12.6 0.1 7.7 5.7 0.1 2.2 2 0 0 2 2 2 0 Thiazole biosynthesis protein ThiG DUF561 PF04481.12 EXF85875.1 - 0.077 12.2 0.1 0.62 9.2 0.0 2.0 1 1 0 2 2 2 0 Protein of unknown function (DUF561) UPF0257 PF06788.13 EXF85875.1 - 0.16 11.8 0.0 0.27 11.0 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0257) PSDC PF12588.8 EXF85876.1 - 7.6e-38 129.7 0.1 1.4e-37 128.8 0.1 1.4 1 0 0 1 1 1 1 Phophatidylserine decarboxylase PS_Dcarbxylase PF02666.15 EXF85876.1 - 5e-30 104.6 0.0 6.9e-30 104.1 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase DUF1929 PF09118.11 EXF85878.1 - 2.9e-22 78.8 0.0 6.6e-22 77.6 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1929) PAN_1 PF00024.26 EXF85878.1 - 3.7e-15 55.6 9.0 5.4e-08 32.7 1.9 2.3 2 0 0 2 2 2 2 PAN domain Kelch_6 PF13964.6 EXF85878.1 - 8.5e-15 54.4 0.0 0.00043 20.5 0.0 3.9 3 0 0 3 3 3 3 Kelch motif Kelch_1 PF01344.25 EXF85878.1 - 6.4e-12 44.9 0.1 0.0005 19.6 0.1 4.2 3 1 0 3 3 3 2 Kelch motif Kelch_2 PF07646.15 EXF85878.1 - 9.5e-10 38.1 0.0 0.0085 16.0 0.0 4.9 4 1 0 4 4 4 3 Kelch motif Kelch_4 PF13418.6 EXF85878.1 - 4e-09 36.3 7.6 0.017 15.1 0.1 6.2 5 2 0 5 5 5 2 Galactose oxidase, central domain Glyoxal_oxid_N PF07250.11 EXF85878.1 - 7.2e-07 28.6 0.0 0.019 14.2 0.0 2.9 2 1 1 3 3 3 2 Glyoxal oxidase N-terminus PAN_4 PF14295.6 EXF85878.1 - 6.4e-05 22.8 9.6 0.045 13.7 1.1 2.7 2 0 0 2 2 2 2 PAN domain MANEC PF07502.14 EXF85878.1 - 0.0035 17.6 7.8 0.31 11.3 0.6 2.4 2 0 0 2 2 2 2 MANEC domain Kelch_3 PF13415.6 EXF85878.1 - 0.031 14.6 0.0 2.1 8.7 0.0 3.4 3 0 0 3 3 3 0 Galactose oxidase, central domain PAN_3 PF08277.12 EXF85878.1 - 0.65 9.9 10.8 4 7.3 1.2 2.4 2 0 0 2 2 2 0 PAN-like domain Ras PF00071.22 EXF85879.1 - 7.3e-40 136.2 0.0 1.4e-37 128.8 0.0 2.1 2 0 0 2 2 2 2 Ras family Roc PF08477.13 EXF85879.1 - 1.8e-31 108.8 0.0 2.7e-31 108.3 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EXF85879.1 - 4.7e-11 42.4 0.0 7.5e-11 41.8 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EXF85879.1 - 1.6e-05 24.9 0.0 2.9e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 EXF85879.1 - 0.006 16.0 0.0 0.0088 15.5 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Herpes_TAF50 PF03326.13 EXF85879.1 - 0.017 13.8 0.4 0.022 13.4 0.4 1.1 1 0 0 1 1 1 0 Herpesvirus transcription activation factor (transactivator) RTP1_C2 PF10304.9 EXF85879.1 - 0.023 14.4 0.6 0.042 13.5 0.6 1.4 1 0 0 1 1 1 0 Required for nuclear transport of RNA pol II C-terminus 2 Gtr1_RagA PF04670.12 EXF85879.1 - 0.21 10.9 0.0 0.33 10.3 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region Sec63 PF02889.16 EXF85880.1 - 1e-137 457.4 0.0 7.1e-82 274.4 0.0 2.2 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.29 EXF85880.1 - 1.1e-49 168.6 0.3 9.3e-26 90.6 0.5 3.4 4 0 0 4 4 4 2 DEAD/DEAH box helicase ResIII PF04851.15 EXF85880.1 - 1.4e-21 77.2 0.0 8.1e-11 42.2 0.0 2.5 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EXF85880.1 - 7e-15 55.3 0.1 2.5e-06 27.8 0.0 4.6 3 2 0 3 3 3 2 Helicase conserved C-terminal domain AAA_22 PF13401.6 EXF85880.1 - 4.2e-07 30.3 0.1 0.039 14.2 0.0 3.6 2 1 0 2 2 2 2 AAA domain AAA_30 PF13604.6 EXF85880.1 - 6.5e-06 26.0 0.1 0.035 13.8 0.2 2.5 2 0 0 2 2 2 2 AAA domain Helicase_PWI PF18149.1 EXF85880.1 - 2.4e-05 24.5 0.0 6e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 N-terminal helicase PWI domain AAA_19 PF13245.6 EXF85880.1 - 3.4e-05 24.2 0.6 0.0085 16.4 0.6 2.6 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 EXF85880.1 - 0.014 15.8 0.1 4.3 7.8 0.0 3.5 2 2 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) T2SSE PF00437.20 EXF85880.1 - 0.019 14.0 0.0 1.2 8.1 0.0 2.5 2 0 0 2 2 2 0 Type II/IV secretion system protein TniB PF05621.11 EXF85880.1 - 0.086 12.2 1.1 21 4.4 0.1 3.6 4 0 0 4 4 4 0 Bacterial TniB protein Synaptobrevin PF00957.21 EXF85881.1 - 2.7e-14 52.7 0.5 4e-14 52.2 0.5 1.2 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 EXF85881.1 - 1.1e-12 47.8 0.0 2.3e-12 46.8 0.0 1.6 1 1 0 1 1 1 1 Regulated-SNARE-like domain ABC_tran_CTD PF16326.5 EXF85882.1 - 9.8e-05 22.5 4.2 9.8e-05 22.5 4.2 5.8 4 3 3 7 7 7 1 ABC transporter C-terminal domain Occludin_ELL PF07303.13 EXF85882.1 - 0.028 15.1 3.0 0.028 15.1 3.0 5.2 2 1 2 5 5 5 0 Occludin homology domain CorA PF01544.18 EXF85882.1 - 1.1 8.5 8.0 0.94 8.7 6.2 1.8 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein DUF4239 PF14023.6 EXF85882.1 - 2.1 8.1 9.8 2.4 7.8 1.8 2.9 1 1 0 2 2 2 0 Protein of unknown function (DUF4239) RNA_pol_Rpb5_C PF01191.19 EXF85883.1 - 2.4e-32 110.6 0.3 4.1e-32 109.9 0.3 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb5, C-terminal domain RNA_pol_Rpb5_N PF03871.14 EXF85883.1 - 9.5e-26 90.2 0.0 1.5e-25 89.6 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb5, N-terminal domain Mrr_cat PF04471.12 EXF85883.1 - 0.051 13.6 0.0 0.5 10.4 0.0 2.1 2 0 0 2 2 2 0 Restriction endonuclease EnY2 PF10163.9 EXF85884.1 - 0.008 16.5 0.1 0.014 15.8 0.1 1.4 1 0 0 1 1 1 1 Transcription factor e(y)2 AAA PF00004.29 EXF85885.1 - 1.9e-98 326.0 0.0 9.7e-48 161.9 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EXF85885.1 - 1.5e-25 88.7 6.0 5.2e-14 51.8 0.3 3.6 2 1 1 3 3 3 2 AAA+ lid domain CDC48_N PF02359.18 EXF85885.1 - 5.2e-19 68.2 0.3 2e-18 66.3 0.3 2.1 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain RuvB_N PF05496.12 EXF85885.1 - 4.1e-14 52.6 1.2 6e-06 26.1 0.0 3.6 4 2 0 4 4 3 2 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 EXF85885.1 - 8.5e-14 52.0 0.0 3.1e-07 30.7 0.0 2.9 2 1 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 EXF85885.1 - 3.6e-13 50.3 0.0 0.00031 21.2 0.0 4.3 2 2 0 2 2 2 2 AAA ATPase domain AAA_5 PF07728.14 EXF85885.1 - 3.6e-12 46.5 0.3 3.5e-06 27.0 0.1 3.7 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 EXF85885.1 - 5.4e-12 46.1 0.0 4.2e-05 23.7 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 EXF85885.1 - 2.5e-09 37.5 0.5 0.029 14.7 0.1 3.9 2 2 1 3 3 2 2 AAA domain TIP49 PF06068.13 EXF85885.1 - 3.5e-09 36.3 0.0 0.0013 18.1 0.0 2.7 2 0 0 2 2 2 2 TIP49 P-loop domain CDC48_2 PF02933.17 EXF85885.1 - 5.6e-08 32.5 0.0 1.4e-07 31.2 0.0 1.7 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 AAA_18 PF13238.6 EXF85885.1 - 1.7e-07 31.9 0.0 0.028 15.0 0.0 2.9 3 0 0 3 3 2 2 AAA domain Mg_chelatase PF01078.21 EXF85885.1 - 2.2e-07 30.5 0.2 0.0069 15.8 0.0 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 EXF85885.1 - 3.5e-07 30.1 0.0 0.019 14.7 0.0 2.7 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_14 PF13173.6 EXF85885.1 - 4.8e-07 29.9 0.0 0.0076 16.3 0.0 2.9 3 0 0 3 3 2 2 AAA domain RNA_helicase PF00910.22 EXF85885.1 - 6.5e-07 29.7 0.0 0.035 14.5 0.0 2.9 3 0 0 3 3 2 2 RNA helicase ATPase PF06745.13 EXF85885.1 - 1e-06 28.3 0.3 0.25 10.6 0.0 3.6 3 0 0 3 3 3 2 KaiC AAA_25 PF13481.6 EXF85885.1 - 1.2e-06 28.2 3.5 0.2 11.2 0.0 4.5 3 2 2 5 5 5 2 AAA domain AAA_7 PF12775.7 EXF85885.1 - 2.1e-06 27.4 0.1 0.032 13.7 0.0 2.9 2 2 0 2 2 2 2 P-loop containing dynein motor region Vps4_C PF09336.10 EXF85885.1 - 2.8e-06 27.2 0.1 3.4e-05 23.8 0.0 2.5 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain AAA_24 PF13479.6 EXF85885.1 - 4.2e-06 26.6 0.0 0.082 12.6 0.0 2.8 3 0 0 3 3 2 2 AAA domain DUF815 PF05673.13 EXF85885.1 - 4.2e-06 26.1 0.0 0.012 14.7 0.0 3.0 3 0 0 3 3 3 2 Protein of unknown function (DUF815) Parvo_NS1 PF01057.17 EXF85885.1 - 8.8e-06 25.0 0.1 0.052 12.6 0.0 2.3 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 AAA_28 PF13521.6 EXF85885.1 - 1.5e-05 25.3 0.1 0.15 12.3 0.0 2.8 3 0 0 3 3 2 2 AAA domain Sigma54_activat PF00158.26 EXF85885.1 - 2.2e-05 24.2 0.0 0.25 11.0 0.0 3.3 2 2 0 2 2 2 2 Sigma-54 interaction domain ABC_tran PF00005.27 EXF85885.1 - 2.9e-05 24.6 0.0 0.28 11.7 0.0 3.5 2 1 0 2 2 2 2 ABC transporter TsaE PF02367.17 EXF85885.1 - 7.9e-05 22.7 0.0 0.44 10.5 0.0 2.5 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE Bac_DnaA PF00308.18 EXF85885.1 - 9e-05 22.4 0.0 0.38 10.5 0.0 3.0 3 0 0 3 3 3 2 Bacterial dnaA protein NACHT PF05729.12 EXF85885.1 - 0.00014 21.9 0.1 0.18 11.7 0.0 2.9 3 0 0 3 3 3 1 NACHT domain AAA_11 PF13086.6 EXF85885.1 - 0.00015 21.6 0.1 1 9.1 0.0 3.0 3 0 0 3 3 3 2 AAA domain ResIII PF04851.15 EXF85885.1 - 0.00015 21.8 0.0 0.046 13.7 0.0 2.5 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_17 PF13207.6 EXF85885.1 - 0.00021 21.7 0.7 0.59 10.6 0.0 3.3 4 0 0 4 4 2 1 AAA domain AAA_3 PF07726.11 EXF85885.1 - 0.00023 21.0 0.0 0.7 9.8 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) PhoH PF02562.16 EXF85885.1 - 0.00023 20.7 0.3 0.68 9.3 0.0 2.5 2 0 0 2 2 2 2 PhoH-like protein AAA_30 PF13604.6 EXF85885.1 - 0.00047 19.9 0.3 1.1 8.9 0.0 2.5 2 0 0 2 2 2 2 AAA domain ATPase_2 PF01637.18 EXF85885.1 - 0.00055 19.9 0.0 2.1 8.2 0.0 3.6 3 1 0 3 3 3 1 ATPase domain predominantly from Archaea AAA_19 PF13245.6 EXF85885.1 - 0.00085 19.7 0.2 5.5 7.3 0.0 3.7 3 1 1 4 4 3 0 AAA domain DUF2075 PF09848.9 EXF85885.1 - 0.002 17.4 0.0 1.7 7.8 0.0 2.3 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) Sigma54_activ_2 PF14532.6 EXF85885.1 - 0.0036 17.4 0.0 0.55 10.3 0.0 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain NB-ARC PF00931.22 EXF85885.1 - 0.0043 16.3 0.0 1.5 8.0 0.0 2.5 2 0 0 2 2 2 1 NB-ARC domain NTPase_1 PF03266.15 EXF85885.1 - 0.006 16.5 0.5 2.5 8.0 0.0 3.8 4 0 0 4 4 3 1 NTPase Viral_helicase1 PF01443.18 EXF85885.1 - 0.0075 16.0 0.0 0.33 10.7 0.0 2.4 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase IPT PF01745.16 EXF85885.1 - 0.013 14.9 0.0 1.8 7.9 0.0 2.3 2 0 0 2 2 2 0 Isopentenyl transferase KAP_NTPase PF07693.14 EXF85885.1 - 0.022 14.0 0.4 1.1 8.4 0.0 3.2 2 2 1 4 4 4 0 KAP family P-loop domain Zeta_toxin PF06414.12 EXF85885.1 - 0.024 13.9 0.6 7.9 5.7 0.0 2.9 3 0 0 3 3 3 0 Zeta toxin UFD1 PF03152.14 EXF85885.1 - 0.03 13.8 0.0 0.17 11.4 0.0 2.0 1 1 1 2 2 2 0 Ubiquitin fusion degradation protein UFD1 AAA_6 PF12774.7 EXF85885.1 - 0.05 12.6 0.1 7.6 5.4 0.0 2.4 2 0 0 2 2 2 0 Hydrolytic ATP binding site of dynein motor region Cytidylate_kin2 PF13189.6 EXF85885.1 - 0.056 13.6 0.0 3.2 7.8 0.0 2.5 2 0 0 2 2 2 0 Cytidylate kinase-like family Cytidylate_kin PF02224.18 EXF85885.1 - 0.06 13.1 0.0 10 5.8 0.0 2.7 2 0 0 2 2 2 0 Cytidylate kinase Zot PF05707.12 EXF85885.1 - 0.074 12.7 0.0 3 7.5 0.0 2.9 2 1 0 2 2 2 0 Zonular occludens toxin (Zot) AFG1_ATPase PF03969.16 EXF85885.1 - 0.097 11.5 0.0 12 4.7 0.0 2.3 2 0 0 2 2 2 0 AFG1-like ATPase YjeF_N PF03853.15 EXF85887.1 - 1.2e-41 142.5 0.3 2.5e-41 141.4 0.1 1.6 2 0 0 2 2 2 1 YjeF-related protein N-terminus FDF PF09532.10 EXF85887.1 - 2e-07 31.8 0.8 2e-07 31.8 0.8 2.2 2 1 0 2 2 2 1 FDF domain PIF1 PF05970.14 EXF85888.1 - 2.9e-59 201.1 0.2 3.1e-45 154.9 0.1 2.3 1 1 1 2 2 2 2 PIF1-like helicase AAA_30 PF13604.6 EXF85888.1 - 2.4e-21 76.3 0.0 4.1e-21 75.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EXF85888.1 - 6e-10 39.6 0.0 1.1e-09 38.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EXF85888.1 - 7.4e-06 26.3 0.0 2.3e-05 24.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 EXF85888.1 - 5.4e-05 22.8 0.0 0.0001 21.9 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA PF00004.29 EXF85888.1 - 9.8e-05 22.8 0.0 0.00028 21.3 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EXF85888.1 - 0.00034 21.0 0.0 0.00083 19.8 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain UvrD_C_2 PF13538.6 EXF85888.1 - 0.00045 20.0 0.0 0.0012 18.6 0.0 1.8 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain Herpes_Helicase PF02689.14 EXF85888.1 - 0.0011 17.0 0.0 0.003 15.6 0.0 1.6 2 0 0 2 2 2 1 Helicase ABC_tran PF00005.27 EXF85888.1 - 0.0017 18.9 1.1 0.0098 16.4 0.0 2.5 1 1 1 2 2 2 1 ABC transporter PhoH PF02562.16 EXF85888.1 - 0.0033 16.9 0.0 0.0072 15.8 0.0 1.5 1 0 0 1 1 1 1 PhoH-like protein AAA_5 PF07728.14 EXF85888.1 - 0.0042 17.1 0.4 0.018 15.0 0.1 2.2 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) DUF5605 PF18310.1 EXF85888.1 - 0.0053 16.6 0.0 2.5 8.0 0.0 3.3 3 0 0 3 3 3 1 Domain of unknown function (DUF5605) RNA_helicase PF00910.22 EXF85888.1 - 0.016 15.6 0.0 0.048 14.0 0.0 1.8 1 0 0 1 1 1 0 RNA helicase ATP-synt_ab PF00006.25 EXF85888.1 - 0.02 14.6 0.0 0.44 10.2 0.0 2.8 3 1 0 3 3 2 0 ATP synthase alpha/beta family, nucleotide-binding domain T2SSE PF00437.20 EXF85888.1 - 0.024 13.7 0.0 0.042 12.9 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein NB-ARC PF00931.22 EXF85888.1 - 0.024 13.8 0.1 0.045 12.9 0.1 1.4 1 0 0 1 1 1 0 NB-ARC domain SH3_13 PF18335.1 EXF85888.1 - 0.028 14.3 0.1 0.11 12.3 0.1 2.1 2 0 0 2 2 1 0 ATP-dependent RecD-like DNA helicase SH3 domain NACHT PF05729.12 EXF85888.1 - 0.039 13.9 0.0 0.079 12.9 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AFG1_ATPase PF03969.16 EXF85888.1 - 0.043 12.7 0.0 0.082 11.8 0.0 1.4 1 0 0 1 1 1 0 AFG1-like ATPase AAA_29 PF13555.6 EXF85888.1 - 0.062 13.0 0.0 0.15 11.8 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain ATPase_2 PF01637.18 EXF85888.1 - 0.062 13.2 0.2 0.28 11.0 0.0 2.1 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea RsgA_GTPase PF03193.16 EXF85888.1 - 0.065 13.1 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase DUF2075 PF09848.9 EXF85888.1 - 0.065 12.5 0.0 0.13 11.4 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_14 PF13173.6 EXF85888.1 - 0.098 12.7 0.0 0.5 10.4 0.0 2.2 2 1 0 2 2 1 0 AAA domain ResIII PF04851.15 EXF85888.1 - 0.11 12.5 0.1 0.26 11.3 0.1 1.6 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit IstB_IS21 PF01695.17 EXF85888.1 - 0.11 12.2 0.1 1.5 8.5 0.0 2.6 3 0 0 3 3 3 0 IstB-like ATP binding protein AAA_11 PF13086.6 EXF85888.1 - 0.12 12.1 0.0 0.12 12.1 0.0 2.6 3 0 0 3 3 3 0 AAA domain DUF1823 PF08853.11 EXF85889.1 - 0.12 12.5 0.1 0.31 11.3 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1823) Prenyltrans PF00432.21 EXF85890.1 - 1.6e-40 136.5 20.5 8.8e-11 41.4 0.4 6.2 6 0 0 6 6 6 6 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_C PF13243.6 EXF85890.1 - 0.086 11.9 0.2 0.35 9.9 0.1 1.9 2 0 0 2 2 2 0 Squalene-hopene cyclase C-terminal domain Zn_clus PF00172.18 EXF85891.1 - 0.0038 17.3 7.7 0.0081 16.3 7.7 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain BRAP2 PF07576.12 EXF85893.1 - 1.9e-29 101.8 0.0 3.4e-29 101.0 0.0 1.4 1 0 0 1 1 1 1 BRCA1-associated protein 2 zf-UBP PF02148.19 EXF85893.1 - 7.8e-19 67.8 4.7 4.7e-18 65.3 5.3 2.0 2 0 0 2 2 1 1 Zn-finger in ubiquitin-hydrolases and other protein zf-RING_2 PF13639.6 EXF85893.1 - 5.9e-09 36.1 9.7 5.9e-09 36.1 9.7 2.3 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 EXF85893.1 - 5.1e-07 29.4 10.4 1.2e-06 28.2 10.4 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EXF85893.1 - 1.2e-06 28.2 4.8 4.8e-06 26.2 4.8 2.2 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4 PF00097.25 EXF85893.1 - 8.4e-06 25.6 8.6 2.4e-05 24.1 8.6 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EXF85893.1 - 2.1e-05 24.5 3.9 2.1e-05 24.5 3.9 2.5 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 EXF85893.1 - 8.8e-05 22.4 8.8 8.8e-05 22.4 8.8 1.9 2 0 0 2 2 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EXF85893.1 - 0.00013 21.7 7.1 0.00013 21.7 7.1 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EXF85893.1 - 0.00029 21.0 7.2 0.00095 19.4 7.2 1.9 1 0 0 1 1 1 1 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 EXF85893.1 - 0.0019 18.0 11.4 0.0019 18.0 11.4 2.9 2 1 1 3 3 2 1 Prokaryotic RING finger family 4 zf-RING_6 PF14835.6 EXF85893.1 - 0.0039 17.0 3.0 0.01 15.7 3.0 1.7 1 0 0 1 1 1 1 zf-RING of BARD1-type protein SHE3 PF17078.5 EXF85893.1 - 0.018 14.8 12.1 0.029 14.1 12.1 1.3 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 NBD94 PF16830.5 EXF85893.1 - 0.02 15.3 0.9 1 9.8 0.4 2.4 2 0 0 2 2 2 0 Nucleotide-Binding Domain 94 of RH FTA4 PF13093.6 EXF85893.1 - 0.04 13.8 6.1 0.065 13.1 6.1 1.2 1 0 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 zf-ANAPC11 PF12861.7 EXF85893.1 - 0.056 13.5 7.4 0.15 12.1 7.4 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.6 EXF85893.1 - 0.2 11.5 7.0 0.45 10.3 7.0 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Filament PF00038.21 EXF85893.1 - 0.23 11.0 16.2 0.34 10.4 16.2 1.2 1 0 0 1 1 1 0 Intermediate filament protein Mto2_bdg PF12808.7 EXF85893.1 - 1.6 9.1 6.6 5.6 7.3 0.6 3.1 2 1 1 3 3 3 0 Micro-tubular organiser Mto1 C-term Mto2-binding region YabA PF06156.13 EXF85893.1 - 1.8 9.2 13.1 0.59 10.8 1.9 2.4 1 1 1 2 2 2 0 Initiation control protein YabA FAM76 PF16046.5 EXF85893.1 - 3.1 7.1 10.4 5.3 6.3 10.4 1.3 1 0 0 1 1 1 0 FAM76 protein FAA_hydro_N_2 PF18288.1 EXF85893.1 - 3.2 8.2 4.8 3.1 8.3 0.3 2.6 1 1 1 2 2 2 0 Fumarylacetoacetase N-terminal domain 2 Exonuc_VII_L PF02601.15 EXF85893.1 - 3.3 7.2 10.8 5.1 6.6 10.8 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit ESCRT-II PF05871.12 EXF85894.1 - 3.6e-59 199.0 0.0 5.2e-59 198.5 0.0 1.2 1 0 0 1 1 1 1 ESCRT-II complex subunit PTCB-BRCT PF12738.7 EXF85895.1 - 1.2e-33 114.8 0.5 1.2e-21 76.4 0.3 4.5 4 0 0 4 4 4 3 twin BRCT domain RTT107_BRCT_5 PF16770.5 EXF85895.1 - 1.3e-33 114.9 0.0 1.1e-30 105.4 0.0 3.9 5 0 0 5 5 5 1 Regulator of Ty1 transposition protein 107 BRCT domain BRCT PF00533.26 EXF85895.1 - 1.4e-29 102.3 0.0 3.8e-11 43.2 0.0 5.3 6 0 0 6 6 6 4 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EXF85895.1 - 7.2e-27 93.6 0.0 1.2e-05 25.7 0.0 6.0 6 0 0 6 6 6 4 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 EXF85895.1 - 8.1e-09 35.7 0.0 0.054 13.8 0.0 3.6 3 0 0 3 3 3 3 DNA ligase 3 BRCT domain GMC_oxred_N PF00732.19 EXF85896.1 - 6.6e-57 193.1 0.0 8.3e-57 192.8 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EXF85896.1 - 1.6e-32 113.0 0.0 3.2e-32 112.0 0.0 1.5 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.24 EXF85896.1 - 3e-05 23.3 1.7 0.0022 17.1 0.4 2.2 2 0 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 EXF85896.1 - 6.2e-05 23.1 0.2 0.00018 21.6 0.2 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 EXF85896.1 - 6.2e-05 22.3 1.2 0.0012 18.2 0.3 2.2 2 0 0 2 2 2 1 Thi4 family DAO PF01266.24 EXF85896.1 - 0.00011 22.0 1.6 0.0018 17.9 0.2 2.4 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EXF85896.1 - 0.0002 20.7 0.5 0.018 14.2 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EXF85896.1 - 0.00021 20.5 0.2 0.00032 19.9 0.2 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein HI0933_like PF03486.14 EXF85896.1 - 0.0017 17.1 0.7 0.11 11.1 0.1 2.1 2 0 0 2 2 2 2 HI0933-like protein Pyr_redox_3 PF13738.6 EXF85896.1 - 0.0099 15.2 1.0 0.11 11.8 0.4 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EXF85896.1 - 0.039 13.2 0.0 0.069 12.4 0.0 1.4 1 0 0 1 1 1 0 FAD binding domain Pyr_redox PF00070.27 EXF85896.1 - 0.079 13.5 0.2 2.1 8.9 0.1 3.2 4 0 0 4 4 4 0 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EXF85896.1 - 0.1 11.7 0.1 0.75 8.9 0.0 2.0 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) p450 PF00067.22 EXF85897.1 - 4.3e-44 151.0 0.0 1e-43 149.8 0.0 1.6 1 1 0 1 1 1 1 Cytochrome P450 adh_short PF00106.25 EXF85898.1 - 5.9e-26 91.1 1.1 7.1e-26 90.9 1.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF85898.1 - 3.3e-22 79.2 1.1 7.9e-22 78.0 1.1 1.5 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF85898.1 - 4.6e-07 29.9 0.1 6.2e-07 29.5 0.1 1.3 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EXF85898.1 - 0.0013 18.0 0.0 0.0015 17.7 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.21 EXF85898.1 - 0.0013 18.2 0.2 0.0096 15.4 0.2 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Shikimate_DH PF01488.20 EXF85898.1 - 0.032 14.3 0.0 0.058 13.5 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase UbiA PF01040.18 EXF85900.1 - 7.8e-14 51.6 4.8 1.4e-13 50.8 4.4 1.5 1 1 0 1 1 1 1 UbiA prenyltransferase family FAD_binding_4 PF01565.23 EXF85901.1 - 1e-24 86.8 3.8 2e-24 85.9 3.8 1.5 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EXF85901.1 - 1.6e-07 31.3 0.1 3.2e-07 30.3 0.1 1.5 1 0 0 1 1 1 1 Berberine and berberine like adh_short PF00106.25 EXF85902.1 - 0.0018 17.8 0.0 0.42 10.0 0.0 2.6 3 0 0 3 3 3 2 short chain dehydrogenase Sec7 PF01369.20 EXF85903.1 - 7.6e-74 247.4 5.9 3.4e-73 245.2 0.9 3.1 3 0 0 3 3 3 1 Sec7 domain Sec7_N PF12783.7 EXF85903.1 - 1.9e-39 135.1 3.1 1.9e-39 135.1 3.1 3.1 3 0 0 3 3 3 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF1981 PF09324.10 EXF85903.1 - 5.4e-34 115.9 10.2 3e-32 110.3 0.1 5.4 5 0 0 5 5 5 2 Domain of unknown function (DUF1981) DCB PF16213.5 EXF85903.1 - 2.4e-23 82.7 3.1 1.9e-22 79.8 0.2 3.2 3 0 0 3 3 3 1 Dimerisation and cyclophilin-binding domain of Mon2 2-oxoacid_dh PF00198.23 EXF85904.1 - 3.4e-73 245.9 0.0 4.4e-73 245.6 0.0 1.2 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 EXF85904.1 - 1.2e-18 66.6 0.5 3.3e-18 65.3 0.5 1.8 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 EXF85904.1 - 5.5e-11 42.6 0.4 1.8e-10 41.0 0.4 1.9 1 0 0 1 1 1 1 e3 binding domain Fungal_trans PF04082.18 EXF85905.1 - 1.5e-13 50.4 0.1 2.5e-13 49.7 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF85905.1 - 2.8e-08 33.7 11.3 2.8e-08 33.7 11.3 1.7 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DASH_Hsk3 PF08227.11 EXF85905.1 - 0.054 13.9 1.1 1.7 9.0 0.2 2.6 2 0 0 2 2 2 0 DASH complex subunit Hsk3 like NAD_binding_10 PF13460.6 EXF85906.1 - 3.4e-05 23.8 0.0 4.5e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding NAD_binding_4 PF07993.12 EXF85906.1 - 0.018 14.2 0.0 0.042 13.0 0.0 1.6 2 0 0 2 2 2 0 Male sterility protein VIT1 PF01988.19 EXF85907.1 - 0.0059 16.5 0.3 0.0081 16.0 0.3 1.2 1 0 0 1 1 1 1 VIT family Methyltransf_23 PF13489.6 EXF85909.1 - 5.8e-20 71.8 0.0 2.2e-19 69.9 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF85909.1 - 2.3e-10 41.1 0.0 7.5e-10 39.4 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF85909.1 - 4.5e-09 36.3 0.0 1.9e-08 34.2 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF85909.1 - 4.2e-07 30.6 0.0 1.4e-06 29.0 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF85909.1 - 2.7e-06 27.9 0.0 5.3e-06 27.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 EXF85909.1 - 0.0043 16.8 0.0 0.027 14.2 0.0 2.0 1 1 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_4 PF02390.17 EXF85909.1 - 0.0067 15.9 0.0 0.021 14.3 0.0 1.8 2 0 0 2 2 2 1 Putative methyltransferase Ubie_methyltran PF01209.18 EXF85909.1 - 0.058 12.7 0.0 1.2 8.5 0.0 2.6 2 1 0 2 2 2 0 ubiE/COQ5 methyltransferase family MTS PF05175.14 EXF85909.1 - 0.086 12.4 0.0 0.17 11.4 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase small domain FtsJ PF01728.19 EXF85909.1 - 0.18 11.9 0.0 0.27 11.3 0.0 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase FAD_binding_3 PF01494.19 EXF85910.1 - 6.7e-12 45.3 0.2 2.1e-06 27.2 0.2 2.9 2 1 0 2 2 2 2 FAD binding domain DAO PF01266.24 EXF85910.1 - 3.7e-08 33.3 0.2 0.0011 18.7 0.0 2.2 1 1 1 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EXF85910.1 - 4.4e-08 32.6 0.0 2.2e-05 23.7 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain Pyr_redox_2 PF07992.14 EXF85910.1 - 2.9e-07 30.0 0.0 0.0011 18.3 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EXF85910.1 - 3.9e-06 25.8 0.0 1.1e-05 24.4 0.0 1.6 2 0 0 2 2 2 1 HI0933-like protein NAD_binding_8 PF13450.6 EXF85910.1 - 8.2e-05 22.8 0.0 0.00022 21.4 0.0 1.8 1 1 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 EXF85910.1 - 0.00021 20.6 0.2 0.00066 19.0 0.0 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EXF85910.1 - 0.00045 19.4 0.0 0.24 10.4 0.0 2.1 2 0 0 2 2 2 2 Lycopene cyclase protein Trp_halogenase PF04820.14 EXF85910.1 - 0.0045 15.9 0.0 0.0092 14.9 0.0 1.5 2 0 0 2 2 2 1 Tryptophan halogenase FAD_oxidored PF12831.7 EXF85910.1 - 0.0066 15.9 0.0 0.0094 15.3 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_7 PF13241.6 EXF85910.1 - 0.0075 16.7 0.0 0.021 15.3 0.0 1.9 1 1 1 2 2 2 1 Putative NAD(P)-binding NAD_binding_9 PF13454.6 EXF85910.1 - 0.019 14.9 0.2 4.8 7.2 0.0 2.3 2 0 0 2 2 2 0 FAD-NAD(P)-binding GIDA PF01134.22 EXF85910.1 - 0.1 11.7 0.6 0.15 11.1 0.0 1.5 2 0 0 2 2 2 0 Glucose inhibited division protein A Pyr_redox PF00070.27 EXF85910.1 - 0.12 13.0 0.1 0.28 11.8 0.1 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase adh_short PF00106.25 EXF85911.1 - 3.8e-35 121.1 1.1 1.3e-21 77.0 0.2 2.2 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EXF85911.1 - 1.1e-32 113.5 0.0 1.8e-18 67.0 0.0 2.3 2 1 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF85911.1 - 1.2e-10 41.6 0.1 3.2e-10 40.2 0.1 1.8 1 0 0 1 1 1 1 KR domain Imm74 PF15603.6 EXF85911.1 - 0.0092 16.2 0.0 0.084 13.1 0.0 2.3 2 0 0 2 2 2 1 Immunity protein 74 Epimerase PF01370.21 EXF85911.1 - 0.0096 15.4 0.1 0.12 11.8 0.1 2.0 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EXF85911.1 - 0.023 13.7 0.0 0.038 13.0 0.0 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 EXF85911.1 - 0.084 12.0 0.0 0.13 11.4 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Shikimate_DH PF01488.20 EXF85911.1 - 0.15 12.1 0.1 0.29 11.2 0.1 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Metallophos PF00149.28 EXF85913.1 - 1.1e-07 32.5 1.5 1.8e-07 31.9 1.5 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Sugar_tr PF00083.24 EXF85914.1 - 7.6e-120 400.8 23.0 8.9e-120 400.6 23.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF85914.1 - 8.8e-18 64.3 48.3 1.3e-11 44.0 20.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2530 PF10745.9 EXF85914.1 - 0.32 11.2 9.5 0.047 13.9 1.2 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2530) Acetyltransf_10 PF13673.7 EXF85915.1 - 2.4e-10 40.5 0.0 4.4e-10 39.6 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EXF85915.1 - 3.3e-09 37.0 0.0 6.3e-09 36.1 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EXF85915.1 - 1.2e-07 32.1 0.0 1.8e-07 31.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EXF85915.1 - 3.2e-05 24.0 0.0 6.3e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_9 PF13527.7 EXF85915.1 - 0.00031 20.8 0.0 0.015 15.4 0.0 2.2 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EXF85915.1 - 0.0042 17.0 0.0 0.0091 15.9 0.0 1.6 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_15 PF17013.5 EXF85915.1 - 0.072 12.5 0.0 0.14 11.6 0.0 1.6 1 1 0 1 1 1 0 Putative acetyl-transferase DUF2551 PF10826.8 EXF85917.1 - 0.07 13.4 0.0 0.18 12.0 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2551) CBM_1 PF00734.18 EXF85919.1 - 5.5e-11 42.2 9.6 5.5e-11 42.2 9.6 2.3 2 0 0 2 2 2 1 Fungal cellulose binding domain Pec_lyase_C PF00544.19 EXF85919.1 - 5.6e-11 42.4 6.0 1.8e-09 37.5 6.0 2.2 1 1 0 1 1 1 1 Pectate lyase Beta_helix PF13229.6 EXF85919.1 - 0.00021 21.2 6.2 0.00048 20.0 5.6 1.8 1 1 0 1 1 1 1 Right handed beta helix region MFS_1 PF07690.16 EXF85921.1 - 3.6e-22 78.8 36.9 1.7e-21 76.6 29.9 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily 2-Hacid_dh_C PF02826.19 EXF85922.1 - 5.3e-42 143.2 0.0 1.8e-27 95.9 0.0 2.2 2 0 0 2 2 2 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.18 EXF85922.1 - 0.094 12.6 0.0 0.14 12.0 0.0 1.2 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Acetyltransf_1 PF00583.25 EXF85923.1 - 5.8e-14 52.3 0.0 9e-14 51.7 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 EXF85923.1 - 3.9e-07 29.9 0.0 6.6e-07 29.2 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_7 PF13508.7 EXF85923.1 - 5.3e-06 26.8 0.0 8.1e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EXF85923.1 - 5.5e-06 26.3 0.0 7.4e-06 25.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 EXF85923.1 - 0.014 15.5 0.0 0.036 14.2 0.0 1.7 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 EXF85923.1 - 0.025 15.3 0.0 0.033 14.9 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Smg4_UPF3 PF03467.15 EXF85923.1 - 0.13 12.3 0.0 0.17 11.9 0.0 1.2 1 0 0 1 1 1 0 Smg-4/UPF3 family PanZ PF12568.8 EXF85923.1 - 0.21 11.3 0.0 0.34 10.7 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain, PanZ Complex1_LYR PF05347.15 EXF85924.1 - 1.1e-06 28.6 1.5 2e-06 27.7 0.2 2.2 2 0 0 2 2 2 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 EXF85924.1 - 0.17 12.7 8.9 0.089 13.5 4.8 2.8 2 1 0 2 2 2 0 Complex1_LYR-like Ank_4 PF13637.6 EXF85925.1 - 2.9e-13 50.0 0.2 4e-07 30.5 0.1 3.8 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EXF85925.1 - 2.9e-09 37.4 0.1 0.006 17.1 0.0 3.5 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EXF85925.1 - 3.2e-08 33.2 1.6 0.02 15.4 0.0 4.6 4 1 0 4 4 4 2 Ankyrin repeat Ank PF00023.30 EXF85925.1 - 2.9e-07 30.6 0.8 0.24 11.9 0.0 4.1 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 EXF85925.1 - 6.7e-06 26.3 0.2 0.012 15.9 0.0 3.1 3 0 0 3 3 3 2 Ankyrin repeats (many copies) KilA-N PF04383.13 EXF85925.1 - 4.5e-05 23.2 0.2 0.00038 20.3 0.2 2.4 1 1 0 1 1 1 1 KilA-N domain Macoilin PF09726.9 EXF85925.1 - 0.018 13.6 1.7 0.03 12.9 1.7 1.4 1 0 0 1 1 1 0 Macoilin family OmpH PF03938.14 EXF85925.1 - 0.078 13.3 3.6 1.2 9.5 3.5 2.3 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) USP8_interact PF08941.10 EXF85925.1 - 0.17 11.7 3.3 0.3 10.9 3.3 1.4 1 0 0 1 1 1 0 USP8 interacting FYVE PF01363.21 EXF85926.1 - 5.8e-25 87.2 20.3 1.1e-17 64.0 3.5 3.0 3 0 0 3 3 3 2 FYVE zinc finger Rbsn PF11464.8 EXF85926.1 - 7.2e-18 64.0 3.5 1.7e-17 62.9 3.5 1.7 1 0 0 1 1 1 1 Rabenosyn Rab binding domain zf-Di19 PF05605.12 EXF85926.1 - 0.00017 21.8 6.0 0.016 15.4 0.1 2.9 2 0 0 2 2 2 2 Drought induced 19 protein (Di19), zinc-binding zf-AN1 PF01428.16 EXF85926.1 - 0.00038 20.5 1.6 0.00038 20.5 1.6 4.0 3 1 1 4 4 4 1 AN1-like Zinc finger zf-C2H2_2 PF12756.7 EXF85926.1 - 0.012 15.9 1.6 1.2 9.5 0.0 2.9 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) Siva PF05458.12 EXF85926.1 - 0.25 11.0 7.8 1.2 8.8 0.3 2.9 2 1 0 2 2 2 0 Cd27 binding protein (Siva) zf-C2H2_9 PF16293.5 EXF85926.1 - 0.3 11.0 2.2 9.5 6.2 0.0 2.8 2 0 0 2 2 2 0 C2H2 type zinc-finger (1 copy) HypA PF01155.19 EXF85926.1 - 1.3 9.0 13.0 0.65 10.0 0.8 3.8 3 1 1 4 4 4 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-ribbon_3 PF13248.6 EXF85926.1 - 5.1 6.7 15.8 6.9 6.2 2.3 4.8 5 0 0 5 5 5 0 zinc-ribbon domain Sirohm_synth_C PF14823.6 EXF85927.1 - 1.7e-26 91.6 0.1 2.7e-26 91.0 0.1 1.3 1 0 0 1 1 1 1 Sirohaem biosynthesis protein C-terminal NAD_binding_7 PF13241.6 EXF85927.1 - 4.6e-26 91.3 1.0 4.2e-21 75.3 0.1 2.3 1 1 1 2 2 2 2 Putative NAD(P)-binding Sirohm_synth_M PF14824.6 EXF85927.1 - 2.9e-16 58.6 0.2 4.8e-16 57.9 0.2 1.4 1 0 0 1 1 1 1 Sirohaem biosynthesis protein central Dynamin_M PF01031.20 EXF85927.1 - 0.086 12.1 0.0 0.12 11.6 0.0 1.1 1 0 0 1 1 1 0 Dynamin central region CENP-L PF13092.6 EXF85928.1 - 4.6e-55 186.3 0.0 8.2e-55 185.5 0.0 1.4 2 0 0 2 2 2 1 Kinetochore complex Sim4 subunit Fta1 Glyco_hydro_10 PF00331.20 EXF85929.1 - 1.9e-106 355.8 0.7 2.2e-106 355.6 0.7 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 10 Beta-prism_lec PF16458.5 EXF85929.1 - 0.02 14.8 0.4 0.094 12.7 0.3 2.0 2 0 0 2 2 2 0 Beta-prism lectin Esterase_phd PF10503.9 EXF85930.1 - 6.2e-22 78.2 0.2 9.2e-22 77.6 0.2 1.2 1 0 0 1 1 1 1 Esterase PHB depolymerase Peptidase_S9 PF00326.21 EXF85930.1 - 2e-08 34.0 1.2 2.8e-08 33.5 1.2 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S10 PF00450.22 EXF85930.1 - 0.0011 18.5 0.1 0.0019 17.7 0.1 1.3 1 0 0 1 1 1 1 Serine carboxypeptidase COesterase PF00135.28 EXF85930.1 - 0.0074 15.2 1.5 0.036 13.0 1.4 1.8 1 1 0 1 1 1 1 Carboxylesterase family Esterase PF00756.20 EXF85930.1 - 0.012 15.2 0.5 0.018 14.7 0.5 1.3 1 0 0 1 1 1 0 Putative esterase BAAT_C PF08840.11 EXF85930.1 - 0.04 13.8 0.2 0.067 13.1 0.2 1.3 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_3 PF07859.13 EXF85930.1 - 0.1 12.5 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold Fungal_trans PF04082.18 EXF85931.1 - 1.7e-27 96.2 0.2 2.4e-27 95.7 0.2 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF85931.1 - 1.5e-06 28.2 8.8 3.5e-06 27.0 8.8 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain GST_C PF00043.25 EXF85932.1 - 1.6e-08 34.6 0.0 2.7e-08 33.9 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EXF85932.1 - 2.6e-06 27.3 0.0 1.5e-05 24.9 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EXF85932.1 - 3.2e-06 27.3 0.0 5.3e-06 26.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EXF85932.1 - 0.00028 21.2 0.0 0.00055 20.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 EXF85932.1 - 0.0039 17.5 0.0 0.0085 16.4 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EXF85932.1 - 0.008 16.5 0.0 0.021 15.1 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_6 PF17171.4 EXF85932.1 - 0.044 13.6 0.0 0.096 12.5 0.0 1.6 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain MFS_1 PF07690.16 EXF85933.1 - 3.1e-31 108.6 20.4 3.1e-31 108.6 20.4 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily DHDPS PF00701.22 EXF85934.1 - 1.9e-37 128.6 0.0 2.2e-37 128.4 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family p450 PF00067.22 EXF85935.1 - 1.1e-60 205.8 0.0 2.6e-60 204.5 0.0 1.4 1 1 0 1 1 1 1 Cytochrome P450 Pyr_redox_2 PF07992.14 EXF85936.1 - 2.2e-34 119.1 0.0 2.8e-34 118.7 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EXF85936.1 - 4.2e-16 59.3 1.8 4.4e-12 46.4 0.1 3.6 4 0 0 4 4 4 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EXF85936.1 - 1.5e-07 31.0 0.0 6.8e-06 25.5 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EXF85936.1 - 0.00033 20.7 0.4 0.34 10.9 0.0 3.7 3 1 1 4 4 4 1 FAD-NAD(P)-binding Lycopene_cycl PF05834.12 EXF85936.1 - 0.0045 16.1 0.5 0.0078 15.3 0.0 1.6 2 0 0 2 2 2 1 Lycopene cyclase protein Thi4 PF01946.17 EXF85936.1 - 0.022 14.0 0.4 1.3 8.2 0.0 2.4 2 0 0 2 2 2 0 Thi4 family TrkA_N PF02254.18 EXF85936.1 - 0.033 14.5 1.6 12 6.2 0.0 3.4 3 1 0 3 3 3 0 TrkA-N domain DAO PF01266.24 EXF85936.1 - 0.044 13.4 5.1 0.29 10.7 0.0 3.5 4 0 0 4 4 4 0 FAD dependent oxidoreductase GerPB PF10803.8 EXF85936.1 - 0.052 13.6 0.1 3.3 7.8 0.1 2.7 2 0 0 2 2 2 0 Spore germination GerPB Trp_halogenase PF04820.14 EXF85936.1 - 0.053 12.4 2.0 5.4 5.7 0.7 2.9 2 1 1 3 3 3 0 Tryptophan halogenase Malic_M PF03949.15 EXF85936.1 - 0.066 12.5 1.3 0.36 10.1 0.0 2.5 2 1 1 3 3 3 0 Malic enzyme, NAD binding domain ThiF PF00899.21 EXF85936.1 - 10 5.4 6.2 12 5.2 0.1 2.8 3 0 0 3 3 3 0 ThiF family Pex16 PF08610.10 EXF85937.1 - 0.15 11.2 0.0 0.15 11.2 0.0 1.1 1 0 0 1 1 1 0 Peroxisomal membrane protein (Pex16) MFS_1 PF07690.16 EXF85938.1 - 2e-40 138.8 14.9 2e-40 138.8 14.9 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF85938.1 - 7.5e-13 48.1 0.8 7.5e-13 48.1 0.8 2.0 3 0 0 3 3 3 1 Sugar (and other) transporter OATP PF03137.20 EXF85938.1 - 0.045 12.0 3.9 0.021 13.1 0.7 1.8 2 1 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family DUF4969 PF16339.5 EXF85938.1 - 0.16 12.3 0.2 0.35 11.2 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4969) Gly_kinase PF02595.15 EXF85939.1 - 3.4e-120 401.4 2.7 4e-120 401.2 2.7 1.0 1 0 0 1 1 1 1 Glycerate kinase family 5_nucleotid_C PF02872.18 EXF85940.1 - 1.7e-43 148.6 0.0 3.5e-43 147.6 0.0 1.5 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain ABC_tran PF00005.27 EXF85940.1 - 4.6e-38 130.8 0.0 1.4e-27 96.9 0.0 2.6 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EXF85940.1 - 1e-23 84.4 15.2 1.6e-23 83.8 15.2 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 EXF85940.1 - 2.7e-06 27.0 0.4 0.12 11.8 0.0 3.3 3 0 0 3 3 3 2 RecF/RecN/SMC N terminal domain Metallophos PF00149.28 EXF85940.1 - 2.9e-06 27.9 0.2 4.8e-06 27.2 0.2 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Mg_chelatase PF01078.21 EXF85940.1 - 0.0065 15.9 0.0 0.013 14.9 0.0 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI SbcCD_C PF13558.6 EXF85940.1 - 0.0069 16.6 0.1 0.86 9.9 0.0 2.9 2 1 0 2 2 2 1 Putative exonuclease SbcCD, C subunit FtsK_SpoIIIE PF01580.18 EXF85940.1 - 0.0073 15.7 0.1 0.017 14.5 0.1 1.5 1 0 0 1 1 1 1 FtsK/SpoIIIE family AAA_21 PF13304.6 EXF85940.1 - 0.0079 16.0 0.0 4 7.2 0.0 3.2 2 1 1 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system MobB PF03205.14 EXF85940.1 - 0.016 15.1 0.1 0.085 12.8 0.0 2.2 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B NTPase_1 PF03266.15 EXF85940.1 - 0.024 14.5 0.1 0.11 12.4 0.0 2.1 2 0 0 2 2 2 0 NTPase AAA_7 PF12775.7 EXF85940.1 - 0.027 14.0 0.0 0.05 13.1 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region DUF87 PF01935.17 EXF85940.1 - 0.034 14.2 1.0 0.074 13.1 1.0 1.5 1 0 0 1 1 1 0 Helicase HerA, central domain AAA_22 PF13401.6 EXF85940.1 - 0.053 13.8 0.1 0.47 10.7 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 EXF85940.1 - 0.076 12.8 0.2 0.21 11.3 0.2 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain Pox_A32 PF04665.12 EXF85940.1 - 0.12 11.8 0.1 0.23 10.9 0.1 1.3 1 0 0 1 1 1 0 Poxvirus A32 protein RsgA_GTPase PF03193.16 EXF85940.1 - 0.13 12.1 0.3 0.37 10.7 0.3 1.7 1 0 0 1 1 1 0 RsgA GTPase Methyltransf_23 PF13489.6 EXF85942.1 - 1.1e-25 90.4 0.0 1.7e-25 89.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF85942.1 - 1.7e-10 41.4 0.0 4.2e-10 40.2 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF85942.1 - 6.5e-09 36.4 0.0 3.5e-08 34.1 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF85942.1 - 2.9e-07 30.4 0.0 1.1e-06 28.5 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF85942.1 - 8e-07 29.6 0.0 1.6e-06 28.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.19 EXF85942.1 - 0.0076 16.4 0.0 0.011 15.8 0.0 1.4 1 0 0 1 1 1 1 FtsJ-like methyltransferase MTS PF05175.14 EXF85942.1 - 0.011 15.3 0.0 0.022 14.3 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_4 PF02390.17 EXF85942.1 - 0.036 13.5 0.0 0.036 13.5 0.0 2.1 2 0 0 2 2 2 0 Putative methyltransferase CopK PF11525.8 EXF85942.1 - 0.083 12.5 0.0 0.17 11.6 0.0 1.5 1 0 0 1 1 1 0 Copper resistance protein K Methyltransf_2 PF00891.18 EXF85942.1 - 0.098 11.9 0.0 0.31 10.3 0.0 1.7 2 0 0 2 2 2 0 O-methyltransferase domain Methyltransf_17 PF12692.7 EXF85942.1 - 0.17 11.9 0.0 2.2 8.3 0.0 2.1 2 0 0 2 2 2 0 S-adenosyl-L-methionine methyltransferase Methyltransf_23 PF13489.6 EXF85943.1 - 4.7e-23 81.8 0.0 9.8e-23 80.8 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF85943.1 - 1e-09 38.9 0.0 2.8e-09 37.6 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF85943.1 - 1.5e-09 37.8 0.0 2.7e-08 33.7 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF85943.1 - 9.1e-08 32.8 0.0 7.2e-07 29.9 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF85943.1 - 2.5e-06 28.0 0.0 4.7e-06 27.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 EXF85943.1 - 0.00028 20.4 0.1 0.0034 16.9 0.0 2.2 2 0 0 2 2 2 1 Putative methyltransferase Ubie_methyltran PF01209.18 EXF85943.1 - 0.0043 16.4 0.0 2.7 7.3 0.0 2.8 3 0 0 3 3 3 2 ubiE/COQ5 methyltransferase family CMAS PF02353.20 EXF85943.1 - 0.0045 16.3 0.0 0.0083 15.4 0.0 1.4 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase FtsJ PF01728.19 EXF85943.1 - 0.011 15.9 0.0 0.016 15.3 0.0 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase PrmA PF06325.13 EXF85943.1 - 0.025 14.0 0.0 0.043 13.2 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 EXF85943.1 - 0.032 13.8 0.0 0.057 13.0 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_23 PF13489.6 EXF85944.1 - 4.1e-23 82.0 0.0 6e-23 81.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF85944.1 - 9.9e-10 39.0 0.0 2.4e-09 37.8 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF85944.1 - 2.3e-08 34.0 0.0 3.8e-07 30.0 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF85944.1 - 8.7e-07 29.6 0.0 4.3e-06 27.4 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF85944.1 - 9e-07 29.5 0.0 1.6e-06 28.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 EXF85944.1 - 0.027 14.0 0.0 0.072 12.6 0.0 1.7 1 0 0 1 1 1 0 Putative methyltransferase PrmA PF06325.13 EXF85944.1 - 0.12 11.7 0.0 0.2 11.0 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 EXF85944.1 - 0.15 11.6 0.0 0.29 10.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain NAD_binding_10 PF13460.6 EXF85945.1 - 4.5e-34 118.0 1.1 5.5e-34 117.7 1.1 1.1 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EXF85945.1 - 3.7e-05 23.3 0.0 8.3e-05 22.2 0.0 1.5 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 EXF85945.1 - 0.076 12.1 0.0 0.12 11.4 0.0 1.3 1 0 0 1 1 1 0 RmlD substrate binding domain peroxidase PF00141.23 EXF85946.1 - 7.6e-21 74.9 0.4 1.3e-20 74.1 0.4 1.2 1 0 0 1 1 1 1 Peroxidase PSI_PSAK PF01241.18 EXF85946.1 - 0.0033 17.4 0.1 0.0075 16.3 0.1 1.6 1 0 0 1 1 1 1 Photosystem I psaG / psaK FMO-like PF00743.19 EXF85947.1 - 2.7e-17 62.4 0.2 9.9e-16 57.2 0.0 2.3 2 1 0 2 2 2 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EXF85947.1 - 4.1e-13 49.2 0.2 2.1e-12 46.9 0.2 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EXF85947.1 - 3.3e-09 36.4 0.0 1.4e-08 34.3 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EXF85947.1 - 9.3e-09 35.4 0.0 3.3e-08 33.7 0.0 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 EXF85947.1 - 5e-07 29.2 0.0 5.3e-06 25.8 0.0 2.0 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.24 EXF85947.1 - 2.5e-05 24.0 0.7 0.2 11.2 0.1 3.3 1 1 1 3 3 3 2 FAD dependent oxidoreductase Thi4 PF01946.17 EXF85947.1 - 3.7e-05 23.1 0.1 0.00013 21.3 0.0 1.8 2 0 0 2 2 2 1 Thi4 family NAD_binding_9 PF13454.6 EXF85947.1 - 0.00036 20.6 0.3 0.0047 16.9 0.0 2.8 3 1 1 4 4 4 1 FAD-NAD(P)-binding Bac_luciferase PF00296.20 EXF85948.1 - 5.1e-54 183.8 1.7 7.7e-54 183.2 1.7 1.2 1 0 0 1 1 1 1 Luciferase-like monooxygenase MFS_1 PF07690.16 EXF85949.1 - 6e-20 71.5 20.5 8.3e-20 71.0 20.5 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily Glyoxalase PF00903.25 EXF85950.1 - 4e-09 36.8 0.0 6.5e-09 36.1 0.0 1.4 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 EXF85950.1 - 0.00058 20.1 0.0 0.00073 19.8 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily TraK PF06586.11 EXF85951.1 - 0.039 13.6 3.4 0.056 13.1 3.4 1.2 1 0 0 1 1 1 0 TraK protein AA_permease PF00324.21 EXF85952.1 - 5.9e-126 420.9 44.8 6.6e-126 420.7 44.8 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EXF85952.1 - 1.6e-27 96.5 49.4 2.3e-27 95.9 49.4 1.2 1 0 0 1 1 1 1 Amino acid permease SAD_SRA PF02182.17 EXF85954.1 - 1.1e-35 122.6 0.0 1.5e-35 122.2 0.0 1.1 1 0 0 1 1 1 1 SAD/SRA domain Zn_clus PF00172.18 EXF85955.1 - 5.9e-07 29.5 9.0 5.9e-07 29.5 9.0 1.7 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EXF85955.1 - 0.11 11.5 0.0 0.18 10.8 0.0 1.2 1 0 0 1 1 1 0 Fungal specific transcription factor domain NmrA PF05368.13 EXF85956.1 - 1.5e-36 126.1 0.0 1.9e-36 125.8 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EXF85956.1 - 3.1e-23 82.6 0.0 4.6e-23 82.1 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EXF85956.1 - 1.3e-05 24.8 0.1 5.2e-05 22.8 0.1 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family adh_short PF00106.25 EXF85956.1 - 0.048 13.1 0.2 0.078 12.4 0.2 1.3 1 0 0 1 1 1 0 short chain dehydrogenase RmlD_sub_bind PF04321.17 EXF85956.1 - 0.069 12.2 0.1 1.1 8.3 0.0 2.1 2 0 0 2 2 2 0 RmlD substrate binding domain NAD_binding_4 PF07993.12 EXF85956.1 - 0.13 11.4 0.0 4.2 6.4 0.0 2.2 1 1 0 2 2 2 0 Male sterility protein GDP_Man_Dehyd PF16363.5 EXF85956.1 - 0.16 11.3 0.0 0.23 10.8 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase GFA PF04828.14 EXF85957.1 - 1.1e-05 25.7 2.3 1.1e-05 25.7 2.3 3.2 3 1 0 3 3 3 2 Glutathione-dependent formaldehyde-activating enzyme MFS_1 PF07690.16 EXF85958.1 - 7.5e-53 179.7 23.9 7.5e-53 179.7 23.9 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF85958.1 - 3.2e-11 42.8 6.9 3.2e-11 42.8 6.9 2.8 3 0 0 3 3 3 1 Sugar (and other) transporter TRI12 PF06609.13 EXF85958.1 - 1.2e-07 30.6 4.9 2.1e-07 29.7 4.9 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_5 PF05631.14 EXF85958.1 - 0.00025 20.1 4.2 0.00092 18.2 1.6 2.1 2 0 0 2 2 2 1 Sugar-tranasporters, 12 TM MFS_3 PF05977.13 EXF85958.1 - 0.0005 18.6 3.5 0.0005 18.6 3.5 1.9 2 0 0 2 2 2 1 Transmembrane secretion effector Phage_holin_2_4 PF16082.5 EXF85958.1 - 0.069 12.9 4.9 0.4 10.4 0.0 3.1 3 0 0 3 3 3 0 Bacteriophage holin family, superfamily II-like OAD_gamma PF04277.13 EXF85958.1 - 0.68 10.6 0.1 0.68 10.6 0.1 2.6 3 0 0 3 3 3 0 Oxaloacetate decarboxylase, gamma chain OATP PF03137.20 EXF85958.1 - 2.1 6.5 8.3 2.6 6.2 3.2 2.7 1 1 1 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family V-SNARE_C PF12352.8 EXF85959.1 - 2.5e-14 53.3 0.3 2.5e-14 53.3 0.3 2.6 3 0 0 3 3 3 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 EXF85959.1 - 7.9e-05 22.5 0.1 0.0012 18.7 0.0 2.5 2 1 1 3 3 3 1 Sec20 KxDL PF10241.9 EXF85959.1 - 0.0041 17.3 1.1 3.3 8.1 0.2 3.1 3 0 0 3 3 3 1 Uncharacterized conserved protein RmuC PF02646.16 EXF85959.1 - 0.0054 15.9 0.2 0.0098 15.1 0.1 1.5 2 0 0 2 2 2 1 RmuC family Sigma70_r4 PF04545.16 EXF85959.1 - 0.013 15.0 0.1 0.033 13.7 0.1 1.6 1 0 0 1 1 1 0 Sigma-70, region 4 CK2S PF15011.6 EXF85959.1 - 0.064 13.1 0.3 0.13 12.1 0.3 1.5 1 0 0 1 1 1 0 Casein Kinase 2 substrate Spc7 PF08317.11 EXF85959.1 - 0.087 11.7 3.6 0.093 11.6 2.5 1.4 2 0 0 2 2 2 0 Spc7 kinetochore protein F_actin_bind PF08919.10 EXF85959.1 - 0.27 11.3 2.2 0.82 9.8 2.2 1.8 1 1 0 1 1 1 0 F-actin binding MscS_porin PF12795.7 EXF85959.1 - 0.62 9.6 8.5 0.079 12.5 4.4 1.5 2 0 0 2 2 2 0 Mechanosensitive ion channel porin domain TPR_MLP1_2 PF07926.12 EXF85959.1 - 0.81 9.8 8.1 1.7 8.7 3.3 2.7 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein DUF745 PF05335.13 EXF85959.1 - 1.4 8.6 6.4 6.6 6.4 3.7 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF745) DUF4337 PF14235.6 EXF85959.1 - 1.4 9.0 3.7 29 4.7 3.7 2.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4337) TPK_catalytic PF04263.16 EXF85960.1 - 1.4e-28 99.4 0.0 2e-28 98.8 0.0 1.2 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, catalytic domain TPK_B1_binding PF04265.14 EXF85960.1 - 1.6e-23 82.2 0.7 2.7e-23 81.4 0.7 1.4 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, vitamin B1 binding domain CHCH PF06747.13 EXF85961.1 - 6.8e-06 26.1 5.0 1.1e-05 25.4 5.0 1.4 1 0 0 1 1 1 1 CHCH domain GCK PF07802.11 EXF85961.1 - 0.13 12.7 2.7 0.33 11.4 2.7 1.7 1 0 0 1 1 1 0 GCK domain DUF5353 PF17304.2 EXF85962.1 - 2.1e-18 65.8 3.4 3e-18 65.3 3.4 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5353) Transport_MerF PF11431.8 EXF85962.1 - 0.089 12.7 0.9 0.089 12.7 0.9 2.1 2 0 0 2 2 2 0 Membrane transport protein MerF Myb_DNA-bind_3 PF12776.7 EXF85963.1 - 1.5e-25 90.0 0.3 1.5e-25 90.0 0.3 2.1 2 0 0 2 2 1 1 Myb/SANT-like DNA-binding domain TFIIA PF03153.13 EXF85963.1 - 1.7e-06 28.3 25.3 2.4e-06 27.8 25.3 1.3 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit SpoIIP PF07454.11 EXF85963.1 - 0.057 12.9 6.8 0.081 12.4 6.8 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Lin-8 PF03353.15 EXF85963.1 - 0.35 10.4 11.9 0.49 9.9 11.9 1.3 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist MMR1 PF08505.10 EXF85963.1 - 0.64 10.3 16.5 1 9.6 16.5 1.3 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein RR_TM4-6 PF06459.12 EXF85963.1 - 0.71 9.6 8.5 1.1 9.0 8.5 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Endostatin PF06482.11 EXF85963.1 - 0.91 8.9 11.7 1.3 8.4 11.7 1.3 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Presenilin PF01080.17 EXF85963.1 - 0.94 8.2 12.2 1.3 7.7 12.2 1.3 1 0 0 1 1 1 0 Presenilin Ndc1_Nup PF09531.10 EXF85963.1 - 1.2 7.8 16.9 1.5 7.4 16.9 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup TERB2 PF15101.6 EXF85963.1 - 1.9 8.5 17.5 3.4 7.7 17.5 1.3 1 0 0 1 1 1 0 Telomere-associated protein TERB2 FAM60A PF15396.6 EXF85963.1 - 2.7 7.9 6.0 6.2 6.8 6.0 1.6 1 0 0 1 1 1 0 Protein Family FAM60A DUF702 PF05142.12 EXF85963.1 - 2.7 8.5 12.8 8.1 6.9 12.8 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF702) CPSF100_C PF13299.6 EXF85963.1 - 4.5 7.4 9.0 8.3 6.6 9.0 1.4 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal eIF-3_zeta PF05091.12 EXF85963.1 - 6.2 5.7 15.3 9.3 5.1 15.3 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF4407 PF14362.6 EXF85963.1 - 6.5 6.0 11.1 10 5.4 11.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Asp PF00026.23 EXF85965.1 - 6.1e-63 213.1 8.3 7.3e-63 212.9 8.3 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EXF85965.1 - 2.8e-08 34.2 2.5 0.0024 18.1 0.3 3.2 2 1 1 3 3 3 2 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EXF85965.1 - 1.3e-05 25.7 2.4 0.015 15.9 0.9 2.9 2 1 0 2 2 2 2 Aspartyl protease SUKH-4 PF14435.6 EXF85965.1 - 0.053 13.6 0.0 0.087 12.9 0.0 1.3 1 0 0 1 1 1 0 SUKH-4 immunity protein gag-asp_proteas PF13975.6 EXF85965.1 - 0.24 12.0 3.0 1.2 9.7 0.7 2.8 2 1 0 2 2 2 0 gag-polyprotein putative aspartyl protease Aminotran_5 PF00266.19 EXF85966.1 - 8.5e-17 61.1 0.0 1.1e-15 57.5 0.0 2.1 1 1 0 1 1 1 1 Aminotransferase class-V ACC_central PF08326.12 EXF85967.1 - 2.5e-276 918.6 0.0 3.2e-276 918.3 0.0 1.1 1 0 0 1 1 1 1 Acetyl-CoA carboxylase, central region Carboxyl_trans PF01039.22 EXF85967.1 - 8.8e-183 608.4 0.0 1.2e-182 608.0 0.0 1.2 1 0 0 1 1 1 1 Carboxyl transferase domain CPSase_L_D2 PF02786.17 EXF85967.1 - 8.6e-51 172.4 0.0 1.6e-50 171.5 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 EXF85967.1 - 1.3e-27 96.5 0.1 2.7e-27 95.5 0.1 1.6 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 EXF85967.1 - 6.4e-22 77.7 0.0 3.4e-20 72.1 0.0 2.9 2 0 0 2 2 2 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 EXF85967.1 - 2.8e-17 62.3 0.1 6e-17 61.2 0.1 1.6 1 0 0 1 1 1 1 Biotin-requiring enzyme GxGYxYP_N PF16216.5 EXF85967.1 - 0.002 18.4 0.1 0.0056 16.9 0.1 1.7 1 0 0 1 1 1 1 GxGYxY sequence motif in domain of unknown function N-terminal Biotin_lipoyl_2 PF13533.6 EXF85967.1 - 0.0024 17.7 0.0 0.0077 16.0 0.0 1.8 1 0 0 1 1 1 1 Biotin-lipoyl like RnfC_N PF13375.6 EXF85967.1 - 0.044 13.7 0.0 0.15 12.0 0.0 1.9 1 0 0 1 1 1 0 RnfC Barrel sandwich hybrid domain ATP-grasp_3 PF02655.14 EXF85967.1 - 0.09 12.8 0.0 0.49 10.4 0.0 2.3 2 0 0 2 2 2 0 ATP-grasp domain Dala_Dala_lig_C PF07478.13 EXF85967.1 - 0.1 12.1 0.0 0.37 10.3 0.0 2.0 2 0 0 2 2 2 0 D-ala D-ala ligase C-terminus ATPgrasp_Ter PF15632.6 EXF85967.1 - 0.16 11.7 0.0 0.35 10.6 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp in the biosynthetic pathway with Ter operon Cwf_Cwc_15 PF04889.12 EXF85968.1 - 0.01 15.6 1.5 0.017 14.9 1.5 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Abhydrolase_1 PF00561.20 EXF85969.1 - 5e-18 65.7 0.0 1e-16 61.4 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EXF85969.1 - 1e-16 62.2 2.9 8.5e-16 59.2 2.9 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EXF85969.1 - 1.6e-11 43.9 0.0 3.4e-11 42.9 0.0 1.5 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Chlorophyllase PF07224.11 EXF85969.1 - 0.038 13.0 0.0 0.06 12.4 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase Chlorophyllase2 PF12740.7 EXF85969.1 - 0.045 12.7 0.0 0.11 11.3 0.0 1.6 2 0 0 2 2 2 0 Chlorophyllase enzyme Esterase PF00756.20 EXF85969.1 - 0.11 12.2 0.1 1.3 8.6 0.0 2.2 2 0 0 2 2 2 0 Putative esterase Glyco_hydro_43 PF04616.14 EXF85970.1 - 8.5e-73 245.2 0.2 1.4e-72 244.5 0.2 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 GH43_C2 PF17851.1 EXF85970.1 - 1.3e-12 47.9 0.0 2.1e-12 47.2 0.0 1.3 1 0 0 1 1 1 1 Beta xylosidase C-terminal Concanavalin A-like domain DUF1349 PF07081.11 EXF85970.1 - 0.0062 16.3 0.0 0.011 15.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1349) Fungal_trans PF04082.18 EXF85971.1 - 9.5e-07 28.1 1.7 1.4e-06 27.6 0.2 2.1 3 0 0 3 3 3 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF85971.1 - 0.00066 19.8 1.7 0.0013 18.8 1.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SQHop_cyclase_C PF13243.6 EXF85971.1 - 0.048 12.8 0.0 0.075 12.1 0.0 1.2 1 0 0 1 1 1 0 Squalene-hopene cyclase C-terminal domain Sugar_tr PF00083.24 EXF85972.1 - 2.7e-70 237.5 16.6 3.1e-70 237.3 16.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF85972.1 - 4.7e-10 38.9 33.2 2e-05 23.7 13.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MttA_Hcf106 PF02416.16 EXF85972.1 - 0.23 10.8 4.3 2.6 7.4 0.2 3.6 4 0 0 4 4 4 0 mttA/Hcf106 family PI-PLC-X PF00388.19 EXF85973.1 - 1e-61 206.8 0.0 1.7e-61 206.0 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 EXF85973.1 - 4.7e-42 143.0 0.0 7.2e-42 142.4 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain FMO-like PF00743.19 EXF85974.1 - 2e-25 89.3 0.0 7.1e-12 44.5 0.0 3.1 3 0 0 3 3 3 3 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EXF85974.1 - 9.3e-11 41.5 0.1 1.9e-08 33.9 0.1 3.0 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EXF85974.1 - 7.1e-08 32.0 0.0 1.4e-06 27.8 0.0 2.4 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EXF85974.1 - 7e-07 28.7 0.5 0.0047 16.1 0.0 3.3 3 1 1 4 4 4 3 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 EXF85974.1 - 1.9e-05 24.7 0.4 0.004 17.1 0.0 3.0 3 0 0 3 3 3 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 EXF85974.1 - 0.00017 21.8 0.0 0.00044 20.4 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Glu_dehyd_C PF16912.5 EXF85974.1 - 0.048 13.1 0.0 0.09 12.3 0.0 1.4 1 0 0 1 1 1 0 Glucose dehydrogenase C-terminus DUF498 PF04430.14 EXF85974.1 - 0.13 12.3 0.0 2.4 8.3 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF498/DUF598) Thi4 PF01946.17 EXF85974.1 - 0.16 11.2 0.1 1 8.5 0.0 2.1 2 0 0 2 2 2 0 Thi4 family NmrA PF05368.13 EXF85976.1 - 3.6e-15 56.1 0.2 5.2e-15 55.6 0.2 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EXF85976.1 - 1.3e-11 44.7 0.1 9.3e-11 42.0 0.1 2.0 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EXF85976.1 - 4.8e-09 36.0 1.0 2.4e-07 30.5 0.2 2.1 1 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family KR PF08659.10 EXF85976.1 - 0.00079 19.4 0.1 0.0013 18.7 0.1 1.4 1 0 0 1 1 1 1 KR domain Shikimate_DH PF01488.20 EXF85976.1 - 0.0042 17.1 0.2 0.02 14.9 0.1 1.9 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase GDP_Man_Dehyd PF16363.5 EXF85976.1 - 0.015 14.8 1.2 0.62 9.4 1.1 2.4 2 1 0 2 2 2 0 GDP-mannose 4,6 dehydratase Sacchrp_dh_NADP PF03435.18 EXF85976.1 - 0.015 15.5 0.3 0.028 14.7 0.3 1.5 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain F420_oxidored PF03807.17 EXF85976.1 - 0.031 14.9 2.1 0.45 11.1 0.7 2.8 2 1 1 3 3 3 0 NADP oxidoreductase coenzyme F420-dependent RmlD_sub_bind PF04321.17 EXF85976.1 - 0.15 11.2 0.3 0.24 10.5 0.1 1.5 2 0 0 2 2 2 0 RmlD substrate binding domain FAD_binding_4 PF01565.23 EXF85978.1 - 4.2e-20 71.9 0.7 7.5e-20 71.1 0.7 1.4 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EXF85978.1 - 0.0031 17.6 0.5 0.0097 16.0 0.2 2.0 2 0 0 2 2 2 1 Berberine and berberine like LysM PF01476.20 EXF85980.1 - 2.8e-07 30.5 0.0 3.4e-07 30.2 0.0 1.2 1 0 0 1 1 1 1 LysM domain adh_short_C2 PF13561.6 EXF85981.1 - 1.2e-54 185.4 0.3 1.7e-54 184.8 0.3 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF85981.1 - 2.3e-46 157.7 2.4 2.8e-46 157.4 2.4 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EXF85981.1 - 3e-14 53.3 0.4 3.9e-14 53.0 0.4 1.1 1 0 0 1 1 1 1 KR domain ADH_zinc_N PF00107.26 EXF85981.1 - 0.0042 17.1 0.9 0.61 10.1 0.2 2.2 1 1 1 2 2 2 2 Zinc-binding dehydrogenase THF_DHG_CYH_C PF02882.19 EXF85981.1 - 0.031 13.6 0.1 0.055 12.8 0.1 1.5 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain NAD_binding_2 PF03446.15 EXF85981.1 - 0.039 14.1 0.2 0.081 13.1 0.2 1.5 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_10 PF13460.6 EXF85981.1 - 0.047 13.6 0.3 0.076 12.9 0.3 1.4 1 0 0 1 1 1 0 NAD(P)H-binding DUF1372 PF07116.11 EXF85981.1 - 0.085 13.0 0.1 0.21 11.8 0.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1372) Podoplanin PF05808.11 EXF85982.1 - 0.0016 18.5 0.6 0.0032 17.6 0.6 1.4 1 0 0 1 1 1 1 Podoplanin DUF2975 PF11188.8 EXF85983.1 - 0.0056 16.6 1.0 0.0073 16.2 1.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2975) DUF4901 PF16244.5 EXF85984.1 - 0.0076 15.6 0.0 0.059 12.7 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4901) Fijivirus_P9-2 PF06837.11 EXF85984.1 - 0.12 11.8 2.2 0.18 11.2 1.3 1.8 2 1 0 2 2 2 0 Fijivirus P9-2 protein DUF1180 PF06679.12 EXF85985.1 - 0.0043 17.5 2.5 0.0043 17.5 2.5 2.2 2 1 0 2 2 2 1 Protein of unknown function (DUF1180) Serglycin PF04360.12 EXF85985.1 - 1.7 8.5 6.7 14 5.6 2.7 2.3 2 0 0 2 2 2 0 Serglycin Catalase PF00199.19 EXF85986.1 - 5.9e-172 572.1 0.5 5.9e-172 572.1 0.5 1.4 2 0 0 2 2 2 1 Catalase Catalase-rel PF06628.12 EXF85986.1 - 8.6e-21 73.9 0.1 1.8e-20 72.9 0.1 1.6 1 0 0 1 1 1 1 Catalase-related immune-responsive Catalase_C PF18011.1 EXF85986.1 - 2.3e-08 33.8 1.3 7.6e-08 32.1 0.8 2.2 2 1 0 2 2 2 1 C-terminal domain found in long catalases DJ-1_PfpI PF01965.24 EXF85986.1 - 1.4e-06 28.3 0.0 2.3e-06 27.5 0.0 1.3 1 0 0 1 1 1 1 DJ-1/PfpI family NFACT-R_1 PF05670.13 EXF85988.1 - 2.8e-28 98.8 0.0 7.4e-28 97.4 0.0 1.7 1 1 0 1 1 1 1 NFACT protein RNA binding domain NDUFA12 PF05071.16 EXF85988.1 - 2 9.3 10.7 0.14 13.0 0.7 2.5 2 1 0 2 2 2 0 NADH ubiquinone oxidoreductase subunit NDUFA12 HeLo PF14479.6 EXF85989.1 - 1.7e-07 31.3 1.1 0.016 15.0 0.1 3.1 2 1 1 3 3 3 2 Prion-inhibition and propagation DUF842 PF05811.13 EXF85990.1 - 0.0021 17.8 1.7 0.042 13.5 0.2 3.8 2 1 1 3 3 3 1 Eukaryotic protein of unknown function (DUF842) DUF4085 PF13315.6 EXF85990.1 - 0.031 13.9 1.6 0.078 12.6 1.6 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF4085) Tup_N PF08581.10 EXF85990.1 - 0.15 12.4 1.3 1.5 9.2 0.1 3.0 2 1 1 3 3 3 0 Tup N-terminal RINGv PF12906.7 EXF85991.1 - 5.8e-17 61.6 9.0 9.5e-17 60.9 9.0 1.4 1 0 0 1 1 1 1 RING-variant domain zf-RING_2 PF13639.6 EXF85991.1 - 0.0054 17.0 8.6 0.0096 16.2 8.6 1.4 1 0 0 1 1 1 1 Ring finger domain zf-ANAPC11 PF12861.7 EXF85991.1 - 0.34 11.0 1.7 0.8 9.8 1.7 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger DUF4834 PF16118.5 EXF85991.1 - 3 8.9 6.4 2.2 9.3 0.0 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) zf-C3HC4_3 PF13920.6 EXF85991.1 - 3.3 7.7 5.5 6.2 6.8 5.5 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) FANCL_C PF11793.8 EXF85991.1 - 4.1 7.7 5.3 7.7 6.8 5.3 1.4 1 0 0 1 1 1 0 FANCL C-terminal domain zf-RING_4 PF14570.6 EXF85991.1 - 4.1 7.3 7.3 7.5 6.4 7.3 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain tRNA-synt_1d PF00750.19 EXF85993.1 - 6.7e-100 334.4 2.6 1.1e-99 333.7 2.6 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.15 EXF85993.1 - 4.5e-29 101.0 0.3 9.1e-29 100.1 0.3 1.5 1 0 0 1 1 1 1 DALR anticodon binding domain Ferric_reduct PF01794.19 EXF85993.1 - 2.5e-16 60.0 15.1 6.4e-16 58.6 15.1 1.8 1 0 0 1 1 1 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 EXF85993.1 - 2.6e-11 43.6 0.0 6.3e-11 42.3 0.0 1.6 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.12 EXF85993.1 - 3.5e-10 40.2 0.0 8.8e-10 38.9 0.0 1.7 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Arg_tRNA_synt_N PF03485.16 EXF85993.1 - 0.017 15.7 0.0 0.041 14.5 0.0 1.7 1 0 0 1 1 1 0 Arginyl tRNA synthetase N terminal domain p450 PF00067.22 EXF85994.1 - 9.7e-54 182.8 0.0 1.9e-53 181.8 0.0 1.4 1 1 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 EXF85995.1 - 4.6e-55 187.2 0.0 5.2e-55 187.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Fungal_trans PF04082.18 EXF85996.1 - 3.3e-23 82.1 0.1 6.1e-23 81.2 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain adh_short PF00106.25 EXF85997.1 - 2.2e-36 125.2 0.0 3.6e-36 124.5 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF85997.1 - 1.8e-35 122.6 0.0 7.2e-35 120.6 0.0 1.8 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF85997.1 - 3.5e-09 36.8 0.5 1.6e-07 31.4 0.0 2.2 2 0 0 2 2 2 1 KR domain Epimerase PF01370.21 EXF85997.1 - 0.016 14.7 0.0 5.2 6.5 0.0 2.1 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family HMG_box PF00505.19 EXF85998.1 - 0.019 15.4 6.4 0.42 11.1 1.7 2.3 2 0 0 2 2 2 0 HMG (high mobility group) box HMG_box_2 PF09011.10 EXF85998.1 - 0.023 15.3 6.4 0.05 14.2 1.6 2.3 2 0 0 2 2 2 0 HMG-box domain LPD39 PF18858.1 EXF85998.1 - 0.039 14.1 1.3 0.17 11.9 0.4 2.0 2 0 0 2 2 2 0 Large polyvalent protein associated domain 39 DUF3106 PF11304.8 EXF85998.1 - 0.04 14.4 6.0 0.63 10.5 0.4 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF3106) TipAS PF07739.13 EXF85998.1 - 0.043 14.4 1.6 0.043 14.4 1.6 1.9 2 0 0 2 2 2 0 TipAS antibiotic-recognition domain AA_permease PF00324.21 EXF85999.1 - 1.7e-121 406.2 35.9 2.3e-121 405.7 35.9 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EXF85999.1 - 5.7e-24 84.7 38.7 7.9e-24 84.3 38.7 1.1 1 0 0 1 1 1 1 Amino acid permease adh_short PF00106.25 EXF86000.1 - 1.5e-27 96.4 2.8 3.7e-18 65.7 0.4 3.1 2 1 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EXF86000.1 - 5e-22 78.6 0.7 1.4e-13 50.9 0.0 3.0 3 0 0 3 3 3 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF86000.1 - 2.9e-05 24.1 0.1 4.7e-05 23.4 0.1 1.4 1 1 0 1 1 1 1 KR domain Amidase PF01425.21 EXF86002.1 - 3.9e-66 223.9 0.2 1.1e-64 219.1 0.0 2.1 2 0 0 2 2 2 2 Amidase GMC_oxred_N PF00732.19 EXF86003.1 - 3.8e-51 174.2 0.0 6e-51 173.6 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EXF86003.1 - 4.7e-28 98.5 0.0 9.9e-28 97.5 0.0 1.6 1 0 0 1 1 1 1 GMC oxidoreductase ABC_tran PF00005.27 EXF86003.1 - 1.5e-26 93.5 0.0 7e-26 91.4 0.0 2.0 2 0 0 2 2 2 1 ABC transporter ABC2_membrane PF01061.24 EXF86003.1 - 2.7e-14 53.1 6.8 4.5e-14 52.4 6.8 1.4 1 0 0 1 1 1 1 ABC-2 type transporter DAO PF01266.24 EXF86003.1 - 2.7e-05 23.9 0.0 5e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EXF86003.1 - 9.5e-05 21.6 0.0 0.088 11.9 0.0 2.3 2 0 0 2 2 2 2 FAD binding domain Thi4 PF01946.17 EXF86003.1 - 0.00013 21.3 0.0 0.00024 20.4 0.0 1.3 1 0 0 1 1 1 1 Thi4 family Lycopene_cycl PF05834.12 EXF86003.1 - 0.00038 19.6 0.0 0.0006 19.0 0.0 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein RsgA_GTPase PF03193.16 EXF86003.1 - 0.00054 19.9 0.4 0.0012 18.8 0.4 1.5 1 0 0 1 1 1 1 RsgA GTPase NAD_binding_8 PF13450.6 EXF86003.1 - 0.0015 18.7 0.0 0.0036 17.5 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain AAA_21 PF13304.6 EXF86003.1 - 0.0038 17.1 0.2 0.012 15.5 0.0 1.7 1 1 1 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system ABC2_membrane_3 PF12698.7 EXF86003.1 - 0.0058 15.8 12.4 0.01 15.0 12.4 1.3 1 0 0 1 1 1 1 ABC-2 family transporter protein Pyr_redox_2 PF07992.14 EXF86003.1 - 0.0084 15.4 0.0 0.021 14.1 0.0 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Dynamin_N PF00350.23 EXF86003.1 - 0.012 15.7 0.2 0.23 11.5 0.0 2.2 2 0 0 2 2 2 0 Dynamin family AAA_29 PF13555.6 EXF86003.1 - 0.029 14.1 1.2 0.094 12.5 1.2 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain NAD_binding_9 PF13454.6 EXF86003.1 - 0.038 14.0 0.2 0.84 9.6 0.0 2.5 2 0 0 2 2 2 0 FAD-NAD(P)-binding MeaB PF03308.16 EXF86003.1 - 0.064 12.2 0.9 0.1 11.5 0.3 1.6 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB MMR_HSR1 PF01926.23 EXF86003.1 - 0.11 12.5 0.8 0.4 10.8 0.6 2.0 2 0 0 2 2 2 0 50S ribosome-binding GTPase HI0933_like PF03486.14 EXF86003.1 - 0.12 11.1 0.4 0.76 8.4 0.0 2.3 3 0 0 3 3 3 0 HI0933-like protein IIGP PF05049.13 EXF86003.1 - 0.14 11.1 0.2 0.35 9.9 0.2 1.6 2 0 0 2 2 2 0 Interferon-inducible GTPase (IIGP) Pyr_redox_3 PF13738.6 EXF86003.1 - 0.15 11.2 0.0 0.34 10.1 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Zeta_toxin PF06414.12 EXF86003.1 - 0.22 10.8 0.1 0.46 9.7 0.1 1.4 1 0 0 1 1 1 0 Zeta toxin HCO3_cotransp PF00955.21 EXF86004.1 - 3.7e-75 253.7 17.3 2.7e-40 138.7 7.0 2.2 1 1 1 2 2 2 2 HCO3- transporter family Zn_clus PF00172.18 EXF86005.1 - 2.1e-10 40.6 10.1 2.1e-10 40.6 10.1 2.0 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Glyco_hydro_3_C PF01915.22 EXF86006.1 - 2e-65 220.6 0.0 4.1e-65 219.6 0.0 1.6 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 EXF86006.1 - 4.7e-47 160.9 0.0 8e-47 160.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 EXF86006.1 - 8e-26 90.0 0.8 2.3e-25 88.5 0.8 1.9 1 0 0 1 1 1 1 Fibronectin type III-like domain PA14 PF07691.12 EXF86006.1 - 1.5e-11 44.3 0.3 2.8e-11 43.4 0.3 1.4 1 0 0 1 1 1 1 PA14 domain Bac_rhamnosid6H PF17389.2 EXF86007.1 - 1.2e-15 57.7 1.6 1.4e-15 57.5 0.0 1.7 2 0 0 2 2 2 1 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain Glyco_hydro_2_N PF02837.18 EXF86007.1 - 2.3e-05 24.3 0.0 0.00023 21.1 0.0 2.3 2 0 0 2 2 2 1 Glycosyl hydrolases family 2, sugar binding domain Bac_rhamnosid_C PF17390.2 EXF86007.1 - 0.17 11.7 0.0 0.71 9.7 0.0 2.1 1 1 0 1 1 1 0 Bacterial alpha-L-rhamnosidase C-terminal domain Sugar_tr PF00083.24 EXF86008.1 - 1.5e-73 248.2 15.8 1.7e-73 248.0 15.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF86008.1 - 1.4e-26 93.3 23.2 2.8e-26 92.3 15.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF5090 PF17009.5 EXF86008.1 - 0.28 11.1 4.3 0.6 10.0 4.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5090) OATP PF03137.20 EXF86008.1 - 0.8 7.9 12.4 0.045 12.0 0.2 2.9 2 1 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family NmrA PF05368.13 EXF86009.1 - 2.4e-10 40.4 0.0 3.4e-10 39.9 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EXF86009.1 - 3.8e-07 30.2 0.3 8.2e-06 25.8 0.3 2.5 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EXF86009.1 - 2.1e-05 24.1 0.0 0.0033 16.9 0.0 2.2 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family KR PF08659.10 EXF86009.1 - 0.0015 18.5 0.0 0.0024 17.8 0.0 1.3 1 0 0 1 1 1 1 KR domain adh_short PF00106.25 EXF86009.1 - 0.017 14.5 0.4 0.029 13.8 0.4 1.3 1 0 0 1 1 1 0 short chain dehydrogenase Caps_synth PF05704.12 EXF86010.1 - 3.4e-15 56.2 0.1 6.5e-15 55.2 0.1 1.4 1 0 0 1 1 1 1 Capsular polysaccharide synthesis protein Gly_transf_sug PF04488.15 EXF86010.1 - 1.6e-05 25.5 0.0 3.7e-05 24.3 0.0 1.6 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Polysacc_synt PF01943.17 EXF86011.1 - 0.031 13.7 14.3 0.44 9.9 8.4 2.2 1 1 1 2 2 2 0 Polysaccharide biosynthesis protein DUF5090 PF17009.5 EXF86011.1 - 0.044 13.8 13.4 0.059 13.3 13.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5090) DUF1180 PF06679.12 EXF86011.1 - 0.15 12.5 0.6 0.32 11.4 0.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) COX1 PF00115.20 EXF86011.1 - 0.23 10.2 11.5 0.46 9.3 11.6 1.4 1 1 0 1 1 1 0 Cytochrome C and Quinol oxidase polypeptide I MARVEL PF01284.23 EXF86011.1 - 0.29 11.2 17.0 0.028 14.4 5.8 2.1 1 1 1 2 2 2 0 Membrane-associating domain Virul_fac_BrkB PF03631.15 EXF86011.1 - 0.47 10.0 15.0 0.64 9.6 15.0 1.2 1 0 0 1 1 1 0 Virulence factor BrkB OAD_gamma PF04277.13 EXF86011.1 - 0.78 10.4 6.7 5.6 7.6 0.3 2.6 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain DUF805 PF05656.14 EXF86011.1 - 1.8 9.0 13.2 7.5 7.0 13.2 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF805) FA_desaturase PF00487.24 EXF86011.1 - 5.6 6.7 6.1 2.5 7.9 3.3 1.7 1 1 1 2 2 2 0 Fatty acid desaturase TMEM43 PF07787.12 EXF86011.1 - 6.8 6.0 13.3 7.7 5.8 12.5 1.5 1 1 0 1 1 1 0 Transmembrane protein 43 Peptidase_M24 PF00557.24 EXF86012.1 - 1.5e-47 162.0 0.0 4.4e-46 157.2 0.0 2.1 1 1 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 EXF86012.1 - 7.1e-23 80.7 0.0 2.3e-22 79.0 0.0 1.8 2 0 0 2 2 2 1 Aminopeptidase P, N-terminal domain Fungal_trans PF04082.18 EXF86013.1 - 6.3e-05 22.1 0.1 0.00014 21.0 0.0 1.5 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF86013.1 - 6.9e-05 22.9 10.5 0.00017 21.7 10.5 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF3926 PF13080.6 EXF86013.1 - 0.12 12.3 0.1 0.33 10.9 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3926) NPP1 PF05630.11 EXF86014.1 - 2.3e-41 142.1 0.0 3.3e-41 141.6 0.0 1.2 1 0 0 1 1 1 1 Necrosis inducing protein (NPP1) Glyco_hydro_1 PF00232.18 EXF86015.1 - 1.4e-139 465.4 2.1 1.8e-139 465.1 2.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 1 Topoisom_I PF01028.20 EXF86016.1 - 2.2e-97 324.8 8.3 4.3e-97 323.9 8.3 1.5 1 0 0 1 1 1 1 Eukaryotic DNA topoisomerase I, catalytic core Topoisom_I_N PF02919.15 EXF86016.1 - 8.5e-97 322.8 5.9 8.5e-97 322.8 5.9 2.8 4 0 0 4 4 4 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Topo_C_assoc PF14370.6 EXF86016.1 - 4.3e-31 106.6 0.6 4.3e-31 106.6 0.6 2.4 2 0 0 2 2 2 1 C-terminal topoisomerase domain VasI PF11319.8 EXF86016.1 - 0.016 14.9 0.1 0.016 14.9 0.1 2.3 2 0 0 2 2 2 0 Type VI secretion system VasI, EvfG, VC_A0118 PspB PF06667.12 EXF86016.1 - 0.066 13.3 0.1 0.26 11.4 0.1 2.0 1 0 0 1 1 1 0 Phage shock protein B BLOC1_2 PF10046.9 EXF86016.1 - 6.8 7.1 7.5 38 4.7 0.9 3.2 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 ATP-synt PF00231.19 EXF86017.1 - 2.2e-78 263.8 2.5 2.7e-78 263.5 2.5 1.0 1 0 0 1 1 1 1 ATP synthase EspA PF03433.13 EXF86017.1 - 0.076 12.9 0.4 4.7 7.0 0.0 2.2 2 0 0 2 2 2 0 EspA-like secreted protein Sec1 PF00995.23 EXF86018.1 - 2e-127 426.9 0.6 2.7e-127 426.4 0.0 1.5 2 0 0 2 2 2 1 Sec1 family Amino_oxidase PF01593.24 EXF86018.1 - 2.1e-80 271.2 0.1 1.7e-68 232.0 0.0 2.2 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase SWIRM PF04433.17 EXF86018.1 - 5.6e-15 55.4 0.0 1.9e-14 53.7 0.0 2.0 1 0 0 1 1 1 1 SWIRM domain NAD_binding_8 PF13450.6 EXF86018.1 - 1.1e-06 28.7 0.0 4.2e-06 26.9 0.0 2.1 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HMG_box PF00505.19 EXF86018.1 - 1.3e-06 28.7 3.7 5.9e-06 26.6 3.7 2.2 1 1 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EXF86018.1 - 0.00013 22.5 3.1 0.00029 21.4 3.1 1.6 1 0 0 1 1 1 1 HMG-box domain Pyr_redox_2 PF07992.14 EXF86018.1 - 0.0037 16.5 0.0 0.15 11.3 0.0 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EXF86018.1 - 0.013 15.1 0.4 0.032 13.8 0.4 1.7 1 0 0 1 1 1 0 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EXF86018.1 - 0.054 13.5 0.6 1.8 8.5 0.0 3.2 3 0 0 3 3 3 0 FAD-NAD(P)-binding UQ_con PF00179.26 EXF86019.1 - 2e-28 98.8 0.0 2.3e-28 98.6 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EXF86019.1 - 1.5e-06 27.9 0.0 2.9e-06 27.0 0.0 1.6 1 1 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 EXF86019.1 - 0.00026 21.2 0.1 0.00031 21.0 0.1 1.2 1 0 0 1 1 1 1 RWD domain UEV PF05743.13 EXF86019.1 - 0.0028 17.5 0.1 0.0037 17.1 0.1 1.2 1 0 0 1 1 1 1 UEV domain Pkinase PF00069.25 EXF86020.1 - 3.2e-66 223.4 0.0 4.3e-66 223.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF86020.1 - 1.4e-30 106.5 0.3 3.1e-30 105.3 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 EXF86020.1 - 0.0023 17.3 0.0 0.0039 16.6 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Gpr1_Fun34_YaaH PF01184.19 EXF86021.1 - 1.1e-82 276.6 17.1 1.4e-82 276.3 17.1 1.1 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family FAD_binding_2 PF00890.24 EXF86022.1 - 1e-65 222.5 4.0 1.2e-65 222.2 4.0 1.0 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 EXF86022.1 - 2.7e-08 33.8 2.1 2.5e-07 30.6 2.0 2.1 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EXF86022.1 - 8.3e-08 32.4 0.7 2.4e-07 30.9 0.7 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EXF86022.1 - 1.5e-07 31.0 2.5 2.5e-06 27.0 0.8 2.7 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EXF86022.1 - 8.1e-06 25.4 2.2 1.4e-05 24.7 2.2 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 EXF86022.1 - 1.4e-05 24.6 0.2 2.1e-05 24.0 0.2 1.3 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 EXF86022.1 - 2.1e-05 23.4 4.6 0.00044 19.1 0.6 3.0 3 0 0 3 3 3 1 HI0933-like protein GIDA PF01134.22 EXF86022.1 - 0.00013 21.1 5.3 0.00085 18.5 0.5 3.0 3 0 0 3 3 3 1 Glucose inhibited division protein A AlaDh_PNT_C PF01262.21 EXF86022.1 - 0.00024 20.5 0.1 0.00024 20.5 0.1 1.8 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain Thi4 PF01946.17 EXF86022.1 - 0.0005 19.4 0.1 0.042 13.1 0.0 2.4 2 0 0 2 2 2 1 Thi4 family Pyr_redox_3 PF13738.6 EXF86022.1 - 0.0011 18.3 0.0 0.063 12.5 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EXF86022.1 - 0.0033 18.0 0.1 0.011 16.3 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EXF86022.1 - 0.015 14.4 1.3 0.059 12.4 0.3 2.0 2 0 0 2 2 2 0 Lycopene cyclase protein 3HCDH_N PF02737.18 EXF86022.1 - 0.058 13.3 0.2 0.095 12.6 0.2 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Peptidase_S8 PF00082.22 EXF86023.1 - 6.5e-34 117.5 15.2 1.2e-33 116.7 15.2 1.4 1 1 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 EXF86023.1 - 1.1e-05 26.0 0.0 4.1e-05 24.2 0.0 2.0 1 1 0 1 1 1 1 Peptidase inhibitor I9 NMT1 PF09084.11 EXF86024.1 - 1.9e-79 266.6 0.0 2.3e-79 266.3 0.0 1.1 1 0 0 1 1 1 1 NMT1/THI5 like NMT1_2 PF13379.6 EXF86024.1 - 5.7e-06 26.2 0.1 0.31 10.7 0.0 3.6 3 1 1 4 4 4 2 NMT1-like family DUF3176 PF11374.8 EXF86025.1 - 1.4 9.1 7.0 1.5 9.0 5.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3176) HET PF06985.11 EXF86026.1 - 0.014 15.7 0.0 0.037 14.4 0.0 1.7 1 0 0 1 1 1 0 Heterokaryon incompatibility protein (HET) Ferritin_2 PF13668.6 EXF86027.1 - 0.0001 22.5 0.0 0.00016 21.9 0.0 1.3 1 0 0 1 1 1 1 Ferritin-like domain AAA_22 PF13401.6 EXF86028.1 - 4.8e-10 39.9 0.0 1.3e-09 38.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 EXF86028.1 - 0.00017 21.6 0.0 0.00035 20.5 0.0 1.5 1 0 0 1 1 1 1 NACHT domain NB-ARC PF00931.22 EXF86028.1 - 0.00035 19.8 0.0 0.00075 18.8 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain AAA_16 PF13191.6 EXF86028.1 - 0.0006 20.2 0.1 0.0006 20.2 0.1 2.0 2 1 0 2 2 2 1 AAA ATPase domain zinc-ribbons_6 PF07191.12 EXF86028.1 - 0.044 13.8 7.2 0.086 12.8 7.2 1.4 1 0 0 1 1 1 0 zinc-ribbons AAA_33 PF13671.6 EXF86028.1 - 0.096 12.8 0.1 0.36 11.0 0.0 2.0 2 0 0 2 2 2 0 AAA domain DUF2039 PF10217.9 EXF86028.1 - 0.62 10.4 8.0 1.6 9.2 8.0 1.7 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2039) Peptidase_S41 PF03572.18 EXF86029.1 - 7.8e-06 25.6 0.0 2.3e-05 24.0 0.0 1.7 1 1 0 1 1 1 1 Peptidase family S41 Bromodomain PF00439.25 EXF86029.1 - 0.17 11.9 0.0 0.44 10.6 0.0 1.6 1 0 0 1 1 1 0 Bromodomain CorA PF01544.18 EXF86030.1 - 2.9e-11 43.2 0.5 7e-11 42.0 0.5 1.6 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein DUF676 PF05057.14 EXF86030.1 - 5.7e-06 26.0 0.0 1.1e-05 25.0 0.0 1.4 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Hydrolase_4 PF12146.8 EXF86030.1 - 0.023 13.9 0.0 0.046 13.0 0.0 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 DUF2960 PF11173.8 EXF86030.1 - 0.068 13.6 0.0 0.18 12.3 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2960) Tropomyosin_1 PF12718.7 EXF86030.1 - 0.44 10.7 15.5 0.84 9.8 15.5 1.5 1 0 0 1 1 1 0 Tropomyosin like F_bP_aldolase PF01116.20 EXF86032.1 - 3.9e-73 246.3 0.0 4.4e-73 246.2 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II CobS PF02654.15 EXF86032.1 - 0.22 11.7 0.1 0.86 9.8 0.0 1.8 2 0 0 2 2 2 0 Cobalamin-5-phosphate synthase HET PF06985.11 EXF86034.1 - 4e-13 49.9 4.3 1.7e-11 44.7 0.3 2.4 1 1 0 2 2 2 2 Heterokaryon incompatibility protein (HET) Aminotran_3 PF00202.21 EXF86036.1 - 3.8e-90 302.5 0.0 4.3e-90 302.3 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 EXF86036.1 - 0.047 12.8 0.0 0.081 12.1 0.0 1.3 1 0 0 1 1 1 0 Aminotransferase class I and II FAD_binding_3 PF01494.19 EXF86037.1 - 2.2e-71 240.9 0.0 2.9e-71 240.6 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EXF86037.1 - 1.3e-05 24.6 0.0 8.8e-05 21.9 0.0 2.0 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EXF86037.1 - 2.8e-05 23.9 0.1 0.00017 21.3 0.1 2.0 1 1 1 2 2 2 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EXF86037.1 - 0.00017 21.6 0.0 0.0003 20.8 0.0 1.4 1 0 0 1 1 1 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 EXF86037.1 - 0.00026 21.1 0.0 0.00078 19.6 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 EXF86037.1 - 0.00047 19.5 0.0 0.0044 16.3 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EXF86037.1 - 0.00053 19.2 0.2 0.017 14.2 0.0 2.1 2 0 0 2 2 2 1 Lycopene cyclase protein HI0933_like PF03486.14 EXF86037.1 - 0.00079 18.2 0.0 0.027 13.2 0.0 2.1 2 0 0 2 2 2 1 HI0933-like protein Thi4 PF01946.17 EXF86037.1 - 0.0016 17.7 0.0 0.0034 16.7 0.0 1.5 1 0 0 1 1 1 1 Thi4 family Pyr_redox PF00070.27 EXF86037.1 - 0.0022 18.5 0.1 0.034 14.7 0.0 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EXF86037.1 - 0.0027 16.8 0.0 0.0038 16.4 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain TrkA_N PF02254.18 EXF86037.1 - 0.047 13.9 0.0 0.089 13.1 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain K_oxygenase PF13434.6 EXF86037.1 - 0.17 11.0 0.0 0.27 10.3 0.0 1.3 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) BTB PF00651.31 EXF86038.1 - 0.00042 20.5 0.0 0.00075 19.7 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain Glyco_hydro_43 PF04616.14 EXF86039.1 - 2.3e-14 53.4 0.7 4e-14 52.6 0.7 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 CBM_35 PF16990.5 EXF86039.1 - 2.4e-07 31.0 0.3 5.8e-07 29.8 0.3 1.7 1 0 0 1 1 1 1 Carbohydrate binding module (family 35) HET PF06985.11 EXF86041.1 - 1.3e-25 90.5 0.2 2.4e-25 89.6 0.2 1.5 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Ribonuclease PF00545.20 EXF86042.1 - 5.7e-09 36.6 0.1 8.9e-09 36.0 0.1 1.3 1 0 0 1 1 1 1 ribonuclease DUF3632 PF12311.8 EXF86043.1 - 1.3e-35 123.4 4.0 2e-35 122.8 4.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3632) ABC_tran PF00005.27 EXF86044.1 - 3.3e-53 179.9 0.0 4.6e-30 104.9 0.0 2.5 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EXF86044.1 - 4.6e-25 88.8 30.7 7.4e-18 65.2 14.1 2.3 2 0 0 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.19 EXF86044.1 - 1.1e-10 41.3 0.3 9.2e-05 22.0 0.1 4.2 4 0 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EXF86044.1 - 5.4e-09 35.7 0.3 0.0051 16.5 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_21 PF13304.6 EXF86044.1 - 6.5e-09 36.0 0.9 0.028 14.2 0.1 3.6 2 1 1 3 3 3 3 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 EXF86044.1 - 1.6e-08 34.9 0.0 0.0029 17.9 0.0 2.9 2 1 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 EXF86044.1 - 8.3e-07 29.1 0.0 0.007 16.3 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase AAA_23 PF13476.6 EXF86044.1 - 3.4e-06 27.7 0.0 0.12 12.9 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EXF86044.1 - 4.7e-06 27.1 0.3 0.14 12.5 0.1 3.0 2 0 0 2 2 2 2 AAA ATPase domain MMR_HSR1 PF01926.23 EXF86044.1 - 9.5e-06 25.7 0.0 0.23 11.5 0.0 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase cobW PF02492.19 EXF86044.1 - 2.5e-05 24.0 0.2 0.015 14.9 0.0 2.5 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.6 EXF86044.1 - 4.2e-05 23.7 0.0 0.098 12.8 0.0 2.6 2 0 0 2 2 2 2 AAA domain Dynamin_N PF00350.23 EXF86044.1 - 8.8e-05 22.6 0.0 0.057 13.5 0.0 2.7 2 0 0 2 2 2 1 Dynamin family AAA_30 PF13604.6 EXF86044.1 - 0.00016 21.5 0.0 0.59 9.8 0.0 2.7 2 1 0 2 2 2 2 AAA domain DUF87 PF01935.17 EXF86044.1 - 0.00018 21.7 0.9 0.0097 16.0 0.0 2.5 2 0 0 2 2 2 1 Helicase HerA, central domain T2SSE PF00437.20 EXF86044.1 - 0.00025 20.2 0.1 0.38 9.8 0.0 2.3 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_25 PF13481.6 EXF86044.1 - 0.00025 20.7 1.8 0.21 11.2 0.0 3.2 3 0 0 3 3 3 1 AAA domain AAA_18 PF13238.6 EXF86044.1 - 0.00055 20.5 0.0 1.7 9.2 0.0 3.1 3 0 0 3 3 2 1 AAA domain Adeno_IVa2 PF02456.15 EXF86044.1 - 0.00076 18.4 0.2 0.29 9.9 0.1 2.9 3 0 0 3 3 3 1 Adenovirus IVa2 protein NACHT PF05729.12 EXF86044.1 - 0.00087 19.2 0.3 0.9 9.4 0.1 2.8 2 0 0 2 2 2 1 NACHT domain AAA_15 PF13175.6 EXF86044.1 - 0.001 18.8 0.0 0.41 10.3 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain Zeta_toxin PF06414.12 EXF86044.1 - 0.0013 18.1 0.1 0.2 10.9 0.0 2.3 2 0 0 2 2 2 1 Zeta toxin FtsK_SpoIIIE PF01580.18 EXF86044.1 - 0.0014 18.1 0.2 0.25 10.7 0.0 2.4 2 0 0 2 2 2 1 FtsK/SpoIIIE family IstB_IS21 PF01695.17 EXF86044.1 - 0.0036 17.0 0.2 14 5.3 0.0 3.9 4 0 0 4 4 4 0 IstB-like ATP binding protein NB-ARC PF00931.22 EXF86044.1 - 0.0036 16.5 0.1 1.4 8.1 0.0 2.6 2 0 0 2 2 2 1 NB-ARC domain Roc PF08477.13 EXF86044.1 - 0.0052 17.0 0.1 2.6 8.3 0.0 3.2 3 0 0 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase AAA_7 PF12775.7 EXF86044.1 - 0.0093 15.5 0.1 5.8 6.4 0.0 2.5 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA PF00004.29 EXF86044.1 - 0.014 15.8 0.0 2.2 8.7 0.0 3.0 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) GTP_EFTU PF00009.27 EXF86044.1 - 0.015 14.9 0.0 2.8 7.4 0.0 2.4 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain Rad17 PF03215.15 EXF86044.1 - 0.029 14.3 0.1 1.5 8.7 0.0 2.4 2 0 0 2 2 2 0 Rad17 P-loop domain G-alpha PF00503.20 EXF86044.1 - 0.041 13.0 0.2 5.5 6.1 0.0 2.9 3 0 0 3 3 3 0 G-protein alpha subunit AAA_14 PF13173.6 EXF86044.1 - 0.058 13.4 0.0 3 7.9 0.0 2.7 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 EXF86044.1 - 0.068 13.1 0.4 7.3 6.5 0.0 2.5 2 0 0 2 2 2 0 NTPase RNA_helicase PF00910.22 EXF86044.1 - 0.075 13.4 0.0 22 5.5 0.0 2.7 2 0 0 2 2 2 0 RNA helicase DUF815 PF05673.13 EXF86044.1 - 0.081 12.1 0.2 11 5.0 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_5 PF07728.14 EXF86044.1 - 0.083 12.9 0.7 4 7.4 0.1 2.8 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) PduV-EutP PF10662.9 EXF86044.1 - 0.085 12.6 0.2 2.6 7.8 0.0 2.6 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation ATPase_2 PF01637.18 EXF86044.1 - 0.087 12.7 0.0 4.1 7.3 0.0 2.5 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea MobB PF03205.14 EXF86044.1 - 0.12 12.3 1.1 40 4.1 0.0 3.3 3 0 0 3 3 3 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_24 PF13479.6 EXF86044.1 - 0.13 12.0 0.1 14 5.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain ATP_bind_1 PF03029.17 EXF86044.1 - 0.16 11.7 0.2 5.4 6.7 0.1 2.3 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein TsaE PF02367.17 EXF86044.1 - 0.19 11.8 0.1 3.8 7.5 0.0 2.3 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE SbcCD_C PF13558.6 EXF86044.1 - 0.23 11.7 0.7 43 4.4 0.0 3.1 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit CLP1_P PF16575.5 EXF86044.1 - 0.26 11.1 1.3 8.8 6.1 0.0 3.2 3 0 0 3 3 3 0 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_28 PF13521.6 EXF86044.1 - 0.3 11.3 1.4 13 6.0 0.1 2.4 2 0 0 2 2 2 0 AAA domain RTA1 PF04479.13 EXF86045.1 - 9e-75 250.8 8.5 1.3e-74 250.3 8.5 1.2 1 0 0 1 1 1 1 RTA1 like protein DUF5381 PF17353.2 EXF86045.1 - 8.5 6.1 10.7 5.8 6.6 0.8 3.1 2 1 0 3 3 3 0 Family of unknown function (DUF5381) Kelch_1 PF01344.25 EXF86046.1 - 2.7e-30 103.7 4.1 4.3e-07 29.4 0.0 6.8 6 1 0 6 6 6 5 Kelch motif Kelch_6 PF13964.6 EXF86046.1 - 6.1e-27 93.0 0.0 3.6e-08 33.4 0.0 6.5 4 1 2 6 6 6 4 Kelch motif Kelch_4 PF13418.6 EXF86046.1 - 5.9e-25 87.0 0.2 7.2e-05 22.7 0.0 5.9 4 1 2 6 6 6 5 Galactose oxidase, central domain Kelch_2 PF07646.15 EXF86046.1 - 4.8e-20 70.7 0.2 0.0017 18.3 0.0 6.6 6 2 0 6 6 6 4 Kelch motif Kelch_3 PF13415.6 EXF86046.1 - 6.8e-14 51.7 0.0 0.0059 16.9 0.1 5.5 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_5 PF13854.6 EXF86046.1 - 2.6e-13 49.6 0.5 0.23 11.5 0.0 5.5 5 0 0 5 5 5 4 Kelch motif Fungal_trans_2 PF11951.8 EXF86046.1 - 1.8e-05 23.7 1.0 2.6e-05 23.2 1.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF86046.1 - 0.013 15.6 11.3 0.18 12.0 11.3 2.3 1 1 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain ADH_zinc_N_2 PF13602.6 EXF86047.1 - 4e-25 89.4 0.0 6.5e-25 88.7 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 EXF86047.1 - 1.3e-16 60.8 0.2 2.3e-16 60.0 0.2 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Tyrosinase PF00264.20 EXF86048.1 - 5.7e-37 128.1 0.4 1.3e-36 127.0 0.4 1.5 1 1 0 1 1 1 1 Common central domain of tyrosinase Glyco_transf_8 PF01501.20 EXF86049.1 - 1.5e-11 44.4 0.0 4.8e-11 42.7 0.0 1.7 1 1 0 1 1 1 1 Glycosyl transferase family 8 tRNA-synt_2c PF01411.19 EXF86051.1 - 4.4e-08 32.1 0.1 5.5e-08 31.8 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (A) tRNA_SAD PF07973.14 EXF86051.1 - 7.8e-06 25.9 0.5 1.3e-05 25.1 0.5 1.4 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain Amidase PF01425.21 EXF86052.1 - 1.4e-104 350.5 0.0 3.1e-104 349.5 0.0 1.5 1 1 0 1 1 1 1 Amidase MFS_1 PF07690.16 EXF86053.1 - 6.9e-33 114.0 22.6 6.9e-33 114.0 22.6 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily MFS_4 PF06779.14 EXF86053.1 - 1.1e-05 25.0 1.0 1.1e-05 25.0 1.0 2.6 2 1 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB 3HCDH_N PF02737.18 EXF86054.1 - 3.2e-31 108.6 0.0 4.8e-31 108.0 0.0 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 EXF86054.1 - 1.7e-14 54.2 0.0 3.2e-14 53.3 0.0 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain DUF5050 PF16472.5 EXF86054.1 - 0.00015 21.1 0.0 0.039 13.2 0.0 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF5050) NAD_Gly3P_dh_N PF01210.23 EXF86054.1 - 0.00044 20.3 0.0 0.00068 19.6 0.0 1.3 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Ldl_recept_b PF00058.17 EXF86054.1 - 0.00057 20.3 0.1 19 5.9 0.0 4.4 4 0 0 4 4 4 1 Low-density lipoprotein receptor repeat class B NAD_binding_2 PF03446.15 EXF86054.1 - 0.0073 16.5 0.0 0.013 15.7 0.0 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Str_synth PF03088.16 EXF86054.1 - 0.015 15.4 0.0 6.6 6.9 0.0 3.2 2 1 0 2 2 2 0 Strictosidine synthase Beta-lactamase PF00144.24 EXF86055.1 - 1.1e-47 162.9 0.0 1.5e-47 162.5 0.0 1.1 1 0 0 1 1 1 1 Beta-lactamase DUF3471 PF11954.8 EXF86055.1 - 4.1e-08 33.6 0.0 8.5e-08 32.6 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3471) BNR_2 PF13088.6 EXF86056.1 - 3.6e-05 23.2 0.1 0.0039 16.5 0.0 2.2 1 1 1 2 2 2 2 BNR repeat-like domain BNR PF02012.20 EXF86056.1 - 8.4e-05 22.0 5.6 0.12 12.5 0.2 3.6 3 0 0 3 3 3 2 BNR/Asp-box repeat Sortilin-Vps10 PF15902.5 EXF86056.1 - 0.00062 18.7 0.2 0.28 9.9 0.0 2.7 3 0 0 3 3 3 2 Sortilin, neurotensin receptor 3, Fungal_trans_2 PF11951.8 EXF86057.1 - 0.0025 16.7 0.0 0.0035 16.2 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF86057.1 - 0.02 15.0 2.9 0.04 14.0 2.9 1.4 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain GFO_IDH_MocA PF01408.22 EXF86058.1 - 1.6e-21 77.4 0.1 3.2e-21 76.4 0.1 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 EXF86058.1 - 3.3e-07 30.3 0.0 6.2e-07 29.4 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain Mt_ATP_synt PF15704.5 EXF86058.1 - 0.0034 17.3 0.0 0.0054 16.6 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial ATP synthase subunit HTH_3 PF01381.22 EXF86058.1 - 0.093 12.8 0.0 0.26 11.4 0.0 1.7 1 1 0 1 1 1 0 Helix-turn-helix Sugar_tr PF00083.24 EXF86059.1 - 1.4e-106 357.1 18.4 1.9e-106 356.6 18.4 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF86059.1 - 1.6e-24 86.6 51.8 6.5e-19 68.1 24.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EXF86059.1 - 4.5e-06 25.4 10.0 0.0022 16.5 3.3 2.1 2 0 0 2 2 2 2 Fungal trichothecene efflux pump (TRI12) UNC-93 PF05978.16 EXF86059.1 - 0.28 10.9 11.7 0.24 11.1 1.7 2.7 3 0 0 3 3 3 0 Ion channel regulatory protein UNC-93 GFO_IDH_MocA PF01408.22 EXF86060.1 - 8.1e-21 75.1 0.0 1e-19 71.6 0.0 2.2 2 0 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold Gp_dh_N PF00044.24 EXF86060.1 - 0.005 17.2 0.0 0.015 15.7 0.0 1.9 2 0 0 2 2 2 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain NAD_binding_2 PF03446.15 EXF86060.1 - 0.11 12.7 0.0 0.16 12.1 0.0 1.3 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Glyco_hydro_7 PF00840.20 EXF86061.1 - 9.8e-92 307.9 0.0 1.5e-54 185.4 0.7 2.0 1 1 1 2 2 2 2 Glycosyl hydrolase family 7 DUF2511 PF10709.9 EXF86061.1 - 0.096 13.0 0.0 2.2 8.6 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2511) Pilin_N PF07790.11 EXF86061.1 - 0.21 12.6 0.2 1.4 9.9 0.1 2.2 2 0 0 2 2 2 0 Archaeal Type IV pilin, N-terminal RPE65 PF03055.15 EXF86062.1 - 2.2e-91 307.4 0.0 2.7e-91 307.1 0.0 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein Glyco_hydro_17 PF00332.18 EXF86063.1 - 2.6e-34 119.3 0.1 6.8e-33 114.6 0.1 2.0 1 1 0 1 1 1 1 Glycosyl hydrolases family 17 Asp PF00026.23 EXF86064.1 - 5.1e-58 197.0 3.7 6.2e-58 196.7 3.7 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EXF86064.1 - 3e-14 53.7 0.7 2.7e-13 50.6 0.4 2.6 2 2 0 2 2 2 1 Xylanase inhibitor N-terminal gag-asp_proteas PF13975.6 EXF86064.1 - 1.4e-05 25.6 0.1 0.13 12.9 0.0 3.4 2 2 0 2 2 2 2 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 EXF86064.1 - 7.6e-05 23.3 0.1 0.38 11.4 0.0 3.1 2 1 0 2 2 2 2 Aspartyl protease DUF3433 PF11915.8 EXF86065.1 - 0.017 15.6 0.2 0.031 14.7 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3433) ADH_zinc_N PF00107.26 EXF86067.1 - 2.7e-21 75.9 0.1 4.1e-21 75.3 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EXF86067.1 - 1.9e-17 63.1 0.0 4.5e-17 61.9 0.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 EXF86067.1 - 4.7e-07 30.9 0.0 8.5e-07 30.1 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase IGFBP PF00219.18 EXF86067.1 - 0.13 13.0 2.2 0.18 12.5 0.2 2.1 2 0 0 2 2 2 0 Insulin-like growth factor binding protein 4HBT PF03061.22 EXF86068.1 - 4.2e-06 27.0 0.0 7.1e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 Thioesterase superfamily DUF4442 PF14539.6 EXF86068.1 - 0.038 14.1 0.1 0.071 13.2 0.1 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4442) DUF3299 PF11736.8 EXF86068.1 - 0.27 11.3 0.7 0.53 10.3 0.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3299) p450 PF00067.22 EXF86069.1 - 4.6e-56 190.5 0.0 6e-56 190.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 YL1_C PF08265.11 EXF86069.1 - 0.086 12.6 1.1 0.13 12.1 0.1 1.9 2 0 0 2 2 2 0 YL1 nuclear protein C-terminal domain Ysc84 PF04366.12 EXF86071.1 - 1.4e-51 173.5 0.0 2.3e-51 172.9 0.0 1.3 1 0 0 1 1 1 1 Las17-binding protein actin regulator DUF604 PF04646.12 EXF86072.1 - 1.9e-09 37.3 0.0 5.4e-07 29.3 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function, DUF604 Fringe PF02434.16 EXF86072.1 - 3.7e-06 26.6 0.0 7.3e-06 25.6 0.0 1.5 1 1 0 1 1 1 1 Fringe-like BRO1 PF03097.18 EXF86073.1 - 1.2e-121 406.2 0.0 1.9e-121 405.6 0.0 1.3 1 0 0 1 1 1 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.6 EXF86073.1 - 2.1e-85 286.6 4.4 2.1e-85 286.6 4.4 1.7 2 0 0 2 2 2 1 ALIX V-shaped domain binding to HIV UPF0242 PF06785.11 EXF86073.1 - 0.25 11.4 7.3 3 7.9 5.1 2.6 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus FAM70 PF14967.6 EXF86073.1 - 2 7.8 3.6 3.7 6.9 3.6 1.3 1 0 0 1 1 1 0 FAM70 protein OmpH PF03938.14 EXF86073.1 - 7.5 6.9 9.8 1.4 9.2 4.5 2.5 3 0 0 3 3 3 0 Outer membrane protein (OmpH-like) HATPase_c PF02518.26 EXF86074.1 - 1.9e-21 76.7 0.1 4.6e-21 75.4 0.1 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EXF86074.1 - 3.8e-18 65.7 0.0 8e-18 64.6 0.0 1.6 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 EXF86074.1 - 1.2e-12 47.7 0.0 3.3e-12 46.2 0.0 1.8 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain GAF PF01590.26 EXF86074.1 - 2.2e-08 34.8 0.0 2.6e-07 31.3 0.0 2.8 3 1 0 3 3 3 1 GAF domain Abhydrolase_3 PF07859.13 EXF86075.1 - 1.9e-54 184.7 0.0 2.5e-54 184.3 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 EXF86075.1 - 2.6e-08 33.2 0.1 2e-07 30.3 0.1 1.9 1 1 0 1 1 1 1 Carboxylesterase family Peptidase_S9 PF00326.21 EXF86075.1 - 0.02 14.3 0.0 6.3 6.2 0.0 2.3 2 0 0 2 2 2 0 Prolyl oligopeptidase family Glyco_hydro_88 PF07470.13 EXF86076.1 - 1.8e-63 214.7 4.7 2.2e-63 214.4 4.7 1.0 1 0 0 1 1 1 1 Glycosyl Hydrolase Family 88 Glyco_hydro_127 PF07944.12 EXF86076.1 - 0.0027 16.3 0.0 0.0038 15.8 0.0 1.1 1 0 0 1 1 1 1 Beta-L-arabinofuranosidase, GH127 C5-epim_C PF06662.13 EXF86076.1 - 0.0038 16.7 0.4 0.058 12.9 0.2 2.5 1 1 1 2 2 2 1 D-glucuronyl C5-epimerase C-terminus HET PF06985.11 EXF86080.1 - 1.1e-11 45.3 5.2 3.3e-09 37.2 1.1 2.5 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) DUF3446 PF11928.8 EXF86080.1 - 0.28 11.5 9.3 0.47 10.8 5.5 2.4 2 0 0 2 2 2 0 Early growth response N-terminal domain SR-25 PF10500.9 EXF86080.1 - 0.85 9.2 9.0 1.4 8.5 9.0 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein IMUP PF15761.5 EXF86080.1 - 5.2 7.8 7.4 9.7 6.9 7.4 1.3 1 0 0 1 1 1 0 Immortalisation up-regulated protein F-box PF00646.33 EXF86081.1 - 0.0034 17.2 0.0 0.0082 16.0 0.0 1.6 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EXF86081.1 - 0.0069 16.2 0.2 0.025 14.5 0.0 2.1 2 0 0 2 2 2 1 F-box-like MFS_1 PF07690.16 EXF86082.1 - 1.7e-13 50.3 22.9 9.8e-09 34.6 20.4 3.0 2 1 1 3 3 3 2 Major Facilitator Superfamily Nodulin-like PF06813.13 EXF86082.1 - 2.5e-05 23.9 9.8 0.011 15.2 0.1 3.0 3 1 1 4 4 4 2 Nodulin-like DUF4271 PF14093.6 EXF86082.1 - 0.59 10.0 0.0 0.59 10.0 0.0 3.5 3 1 0 3 3 3 0 Domain of unknown function (DUF4271) zf-CCCH_3 PF15663.5 EXF86083.1 - 0.065 13.5 0.0 0.14 12.3 0.0 1.6 1 0 0 1 1 1 0 Zinc-finger containing family Pkinase PF00069.25 EXF86085.1 - 5.7e-21 75.1 0.0 2.1e-20 73.2 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF86085.1 - 1.4e-11 44.2 0.0 2e-10 40.4 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Pyr_redox_2 PF07992.14 EXF86087.1 - 4.5e-07 29.4 0.1 2.2e-05 23.9 0.0 2.8 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EXF86087.1 - 1.7e-05 24.2 0.0 4.7e-05 22.7 0.0 1.7 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) FMO-like PF00743.19 EXF86087.1 - 0.00013 20.5 0.0 0.0027 16.2 0.0 2.1 2 0 0 2 2 2 1 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.6 EXF86087.1 - 0.0014 18.9 0.2 0.0039 17.4 0.2 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 EXF86087.1 - 0.0023 17.2 0.0 0.04 13.2 0.0 2.8 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase ThiF PF00899.21 EXF86087.1 - 0.11 11.8 0.0 1.1 8.6 0.0 2.1 2 0 0 2 2 2 0 ThiF family Shikimate_DH PF01488.20 EXF86087.1 - 0.15 12.1 0.0 3 7.9 0.0 2.2 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Methyltransf_25 PF13649.6 EXF86089.1 - 2.8e-14 53.6 0.0 5.1e-14 52.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF86089.1 - 1.8e-13 50.9 0.0 3.2e-13 50.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EXF86089.1 - 4.1e-10 39.7 0.0 5.2e-10 39.4 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF86089.1 - 1.5e-08 34.5 0.0 2.4e-08 33.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF86089.1 - 1.9e-08 35.0 0.0 3.1e-08 34.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EXF86089.1 - 1.5e-06 27.8 0.0 2e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 EXF86089.1 - 2.5e-05 23.9 0.0 3.3e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Ubie_methyltran PF01209.18 EXF86089.1 - 0.00046 19.6 0.1 0.0008 18.8 0.1 1.4 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family MetW PF07021.12 EXF86089.1 - 0.0005 19.7 0.0 0.00073 19.2 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW CMAS PF02353.20 EXF86089.1 - 0.0016 17.8 0.0 0.0024 17.2 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase ADH_zinc_N PF00107.26 EXF86089.1 - 0.0053 16.7 0.1 0.02 14.9 0.1 1.8 1 1 0 1 1 1 1 Zinc-binding dehydrogenase Methyltransf_16 PF10294.9 EXF86089.1 - 0.011 15.5 0.3 0.021 14.6 0.2 1.4 1 1 0 1 1 1 0 Lysine methyltransferase TPMT PF05724.11 EXF86089.1 - 0.012 15.3 0.0 0.018 14.7 0.0 1.2 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) TehB PF03848.14 EXF86089.1 - 0.057 12.8 0.2 0.13 11.6 0.0 1.6 2 1 0 2 2 2 0 Tellurite resistance protein TehB Methyltransf_32 PF13679.6 EXF86089.1 - 0.12 12.3 0.0 0.19 11.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_29 PF03141.16 EXF86089.1 - 0.22 10.0 0.0 0.28 9.7 0.0 1.2 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Fungal_trans PF04082.18 EXF86090.1 - 1.7e-23 83.0 0.0 2.6e-23 82.4 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF86090.1 - 5.9e-08 32.7 13.7 1.5e-07 31.5 13.7 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Tmemb_cc2 PF10267.9 EXF86090.1 - 0.0029 16.8 0.0 0.004 16.4 0.0 1.1 1 0 0 1 1 1 1 Predicted transmembrane and coiled-coil 2 protein Zip PF02535.22 EXF86091.1 - 1.6e-52 178.8 2.2 5.5e-52 177.0 2.2 1.7 1 1 0 1 1 1 1 ZIP Zinc transporter Cation_efflux PF01545.21 EXF86092.1 - 1.7e-25 90.0 14.6 2.1e-25 89.6 14.6 1.1 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 EXF86092.1 - 3.3e-09 36.8 0.2 6.9e-09 35.7 0.2 1.5 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter SHNi-TPR PF10516.9 EXF86093.1 - 0.056 12.9 0.0 0.11 11.9 0.0 1.5 1 0 0 1 1 1 0 SHNi-TPR Hexapep PF00132.24 EXF86094.1 - 6.8e-08 31.9 12.0 1.5e-05 24.6 2.7 3.6 4 0 0 4 4 4 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 EXF86094.1 - 7.4e-06 25.6 13.5 0.0038 16.9 2.2 3.0 2 1 0 2 2 2 2 Hexapeptide repeat of succinyl-transferase Fucokinase PF07959.12 EXF86094.1 - 0.12 11.3 0.3 1.7 7.5 0.0 2.0 1 1 1 2 2 2 0 L-fucokinase Complex1_51K PF01512.17 EXF86095.1 - 2.3e-47 160.7 0.0 3.6e-47 160.1 0.0 1.3 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase 51 Kd subunit NADH_4Fe-4S PF10589.9 EXF86095.1 - 4.6e-29 100.3 0.9 8.4e-29 99.5 0.1 1.8 2 0 0 2 2 2 1 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region SLBB PF10531.9 EXF86095.1 - 8.5e-09 35.2 0.0 2.2e-08 33.9 0.0 1.7 1 0 0 1 1 1 1 SLBB domain PEX11 PF05648.14 EXF86096.1 - 3.6e-15 56.1 0.1 1.6e-09 37.6 0.1 3.2 2 2 0 2 2 2 2 Peroxisomal biogenesis factor 11 (PEX11) IFT57 PF10498.9 EXF86096.1 - 0.17 10.9 0.1 0.2 10.6 0.1 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 DUF5384 PF17358.2 EXF86096.1 - 0.49 10.4 7.0 0.43 10.6 5.6 1.5 2 0 0 2 2 2 0 Family of unknown function (DUF5384) CUE PF02845.16 EXF86098.1 - 5.9e-07 29.1 0.8 0.0003 20.4 0.1 3.1 3 0 0 3 3 3 2 CUE domain Smr PF01713.21 EXF86098.1 - 0.00094 19.5 0.1 0.003 17.9 0.1 1.9 1 0 0 1 1 1 1 Smr domain DUF1771 PF08590.10 EXF86098.1 - 0.39 11.1 6.8 0.77 10.2 6.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1771) Amidase PF01425.21 EXF86099.1 - 4.2e-74 250.1 0.0 8.9e-73 245.8 0.0 2.0 1 1 0 1 1 1 1 Amidase Acyltransferase PF01553.21 EXF86100.1 - 1e-10 41.4 0.0 1.3e-05 24.9 0.0 2.3 2 0 0 2 2 2 2 Acyltransferase ABC2_membrane_4 PF12730.7 EXF86100.1 - 0.64 10.0 4.9 2.5 8.0 0.9 2.4 2 0 0 2 2 2 0 ABC-2 family transporter protein Suc_Fer-like PF06999.12 EXF86101.1 - 3.9e-72 242.2 0.0 4.5e-72 242.0 0.0 1.0 1 0 0 1 1 1 1 Sucrase/ferredoxin-like Drf_GBD PF06371.13 EXF86102.1 - 1.4e-15 57.4 1.4 3.6e-14 52.8 1.4 2.3 1 1 0 1 1 1 1 Diaphanous GTPase-binding Domain RraA-like PF03737.15 EXF86103.1 - 4.5e-26 91.8 0.3 5.6e-26 91.5 0.3 1.1 1 0 0 1 1 1 1 Aldolase/RraA UCR_hinge PF02320.16 EXF86105.1 - 1.5e-25 89.2 11.4 1.5e-25 89.2 11.4 2.3 2 0 0 2 2 2 1 Ubiquinol-cytochrome C reductase hinge protein RNA_pol_3_Rpc31 PF11705.8 EXF86105.1 - 0.065 13.5 14.0 0.14 12.4 14.0 1.7 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Vps36_ESCRT-II PF11605.8 EXF86105.1 - 0.07 13.3 0.0 0.17 12.1 0.0 1.6 1 0 0 1 1 1 0 Vacuolar protein sorting protein 36 Vps36 Nop14 PF04147.12 EXF86105.1 - 0.15 10.3 18.6 0.21 9.8 18.6 1.2 1 0 0 1 1 1 0 Nop14-like family CENP-N PF05238.13 EXF86105.1 - 0.19 11.0 5.7 0.34 10.2 5.7 1.4 1 0 0 1 1 1 0 Kinetochore protein CHL4 like DUF4820 PF16091.5 EXF86105.1 - 0.25 10.7 8.1 0.49 9.7 8.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) RR_TM4-6 PF06459.12 EXF86105.1 - 0.42 10.4 19.0 0.82 9.4 19.0 1.5 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CDC45 PF02724.14 EXF86105.1 - 0.62 8.3 12.9 0.87 7.8 12.9 1.2 1 0 0 1 1 1 0 CDC45-like protein Asp-B-Hydro_N PF05279.11 EXF86105.1 - 0.67 10.0 21.1 1.2 9.2 21.1 1.4 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region SpoIIP PF07454.11 EXF86105.1 - 0.82 9.1 8.6 1.4 8.3 8.6 1.3 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DUF5523 PF17661.1 EXF86105.1 - 1.7 8.3 20.2 2.8 7.6 20.2 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5523) DDHD PF02862.17 EXF86105.1 - 1.7 8.7 6.3 1.1 9.3 3.9 1.9 2 0 0 2 2 2 0 DDHD domain Paf1 PF03985.13 EXF86105.1 - 2.2 7.2 19.9 4.3 6.2 19.9 1.4 1 0 0 1 1 1 0 Paf1 TLP-20 PF06088.11 EXF86105.1 - 3.7 7.4 6.0 7.8 6.3 6.0 1.5 1 0 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) SAPS PF04499.15 EXF86105.1 - 4.4 6.0 8.6 6.3 5.5 8.6 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein RPN2_C PF18004.1 EXF86105.1 - 6.5 6.7 17.7 0.34 10.8 11.3 2.1 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain AIF_C PF14721.6 EXF86105.1 - 8 6.8 5.6 19 5.6 5.6 1.7 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term DUF913 PF06025.12 EXF86105.1 - 8.4 5.3 9.0 15 4.5 9.0 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) PPP4R2 PF09184.11 EXF86105.1 - 8.5 5.9 19.2 14 5.2 19.2 1.3 1 0 0 1 1 1 0 PPP4R2 Pox_Ag35 PF03286.14 EXF86105.1 - 9.9 5.9 20.9 0.1 12.4 11.6 2.2 2 0 0 2 2 2 0 Pox virus Ag35 surface protein Aminotran_5 PF00266.19 EXF86106.1 - 4e-07 29.3 0.0 2.4e-05 23.4 0.0 2.3 2 1 0 2 2 2 2 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 EXF86106.1 - 0.00012 20.8 0.0 0.00018 20.2 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 EXF86106.1 - 0.0057 16.0 0.0 0.0082 15.5 0.0 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family SAM_2 PF07647.17 EXF86108.1 - 1.4e-16 60.3 0.0 2.7e-16 59.4 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 EXF86108.1 - 1.5e-15 57.4 0.0 2.6e-15 56.6 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) RA PF00788.23 EXF86108.1 - 8.1e-11 42.4 0.0 1.9e-10 41.3 0.0 1.6 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain SAM_4 PF18017.1 EXF86108.1 - 0.00038 20.4 0.0 0.00067 19.6 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) CCDC66 PF15236.6 EXF86108.1 - 0.77 9.6 3.1 2.2 8.1 0.1 2.4 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 66 Myosin_tail_1 PF01576.19 EXF86109.1 - 0.00067 17.6 20.9 0.00085 17.3 20.9 1.0 1 0 0 1 1 1 1 Myosin tail Lebercilin PF15619.6 EXF86109.1 - 0.0029 17.3 7.0 0.0029 17.3 7.0 2.2 1 1 1 2 2 2 1 Ciliary protein causing Leber congenital amaurosis disease APG6_N PF17675.1 EXF86109.1 - 0.0053 17.3 25.3 0.086 13.4 22.0 2.5 1 1 1 2 2 2 1 Apg6 coiled-coil region GAS PF13851.6 EXF86109.1 - 0.0059 16.0 24.5 0.1 12.0 12.7 2.7 1 1 3 4 4 4 3 Growth-arrest specific micro-tubule binding DUF3811 PF11656.8 EXF86109.1 - 0.0076 16.6 3.5 0.0076 16.6 3.5 2.3 2 0 0 2 2 2 1 YjbD family (DUF3811) HIP1_clath_bdg PF16515.5 EXF86109.1 - 0.013 16.1 9.9 0.013 16.1 9.9 2.9 2 1 1 3 3 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Baculo_PEP_C PF04513.12 EXF86109.1 - 0.041 13.9 5.2 0.17 11.9 3.3 2.3 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Spc7 PF08317.11 EXF86109.1 - 0.11 11.4 23.7 2.3 7.0 23.3 2.4 1 1 0 1 1 1 0 Spc7 kinetochore protein FapA PF03961.13 EXF86109.1 - 0.14 10.7 19.1 0.054 12.1 8.3 2.0 1 1 1 2 2 2 0 Flagellar Assembly Protein A Golgin_A5 PF09787.9 EXF86109.1 - 0.15 11.5 19.8 0.071 12.6 15.3 2.1 1 1 1 2 2 2 0 Golgin subfamily A member 5 DUF3584 PF12128.8 EXF86109.1 - 0.21 9.0 20.3 0.38 8.2 20.3 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) DUF4407 PF14362.6 EXF86109.1 - 0.31 10.4 12.6 0.24 10.7 10.4 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) DUF745 PF05335.13 EXF86109.1 - 0.31 10.7 8.0 3.3 7.4 3.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF745) CENP-H PF05837.12 EXF86109.1 - 0.33 11.4 21.4 0.22 11.9 7.0 3.1 1 1 2 3 3 3 0 Centromere protein H (CENP-H) TPR_MLP1_2 PF07926.12 EXF86109.1 - 0.33 11.0 24.9 2 8.5 15.7 3.6 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Fez1 PF06818.15 EXF86109.1 - 0.34 11.3 23.6 1.1e+02 3.1 23.0 2.4 1 1 0 1 1 1 0 Fez1 Tweety PF04906.13 EXF86109.1 - 0.35 9.5 2.8 0.27 9.9 1.2 1.5 1 1 1 2 2 2 0 Tweety CENP-F_leu_zip PF10473.9 EXF86109.1 - 0.49 10.4 26.7 0.55 10.2 14.4 2.7 1 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Fib_alpha PF08702.10 EXF86109.1 - 0.56 10.4 17.0 0.15 12.3 2.9 2.2 1 1 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF148 PF02520.17 EXF86109.1 - 1.2 9.3 9.2 0.63 10.2 4.8 2.5 2 2 0 2 2 2 0 Domain of unknown function DUF148 DLP_helical PF18709.1 EXF86109.1 - 1.3 8.2 12.8 0.15 11.2 1.7 2.9 1 1 2 3 3 3 0 Dynamin-like helical domain DUF4201 PF13870.6 EXF86109.1 - 1.6 8.5 23.3 1.1 8.9 12.0 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) DUF3053 PF11254.8 EXF86109.1 - 1.7 8.1 8.9 3.4 7.2 0.4 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3053) Seryl_tRNA_N PF02403.22 EXF86109.1 - 1.8 8.9 20.5 0.59 10.4 11.7 2.9 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF4558 PF15104.6 EXF86109.1 - 1.8 8.7 11.7 9 6.4 0.1 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF4558) Ku_C PF03730.14 EXF86109.1 - 1.8 9.3 8.4 0.47 11.2 4.9 1.8 2 0 0 2 2 1 0 Ku70/Ku80 C-terminal arm LXG PF04740.12 EXF86109.1 - 1.9 8.1 12.2 2.7 7.7 6.6 2.4 1 1 1 2 2 2 0 LXG domain of WXG superfamily PEP-utilisers_N PF05524.13 EXF86109.1 - 2.1 8.5 5.6 8.8 6.5 2.0 2.4 1 1 1 2 2 2 0 PEP-utilising enzyme, N-terminal TSNAXIP1_N PF15739.5 EXF86109.1 - 2.2 8.7 11.3 0.99 9.8 5.1 2.8 1 1 1 3 3 3 0 Translin-associated factor X-interacting N-terminus TMPIT PF07851.13 EXF86109.1 - 2.3 7.4 14.7 1.7 7.8 6.6 2.3 1 1 2 3 3 3 0 TMPIT-like protein Peptidase_C98 PF15499.6 EXF86109.1 - 2.3 7.6 7.3 1.5 8.2 3.1 2.0 1 1 1 2 2 2 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase PMEI PF04043.15 EXF86109.1 - 2.3 8.5 9.4 1.9 8.8 1.0 2.3 1 1 1 2 2 2 0 Plant invertase/pectin methylesterase inhibitor DUF1664 PF07889.12 EXF86109.1 - 2.6 8.1 12.2 3.4 7.7 4.7 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) OmpH PF03938.14 EXF86109.1 - 2.7 8.3 15.2 10 6.5 0.4 2.5 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) DUF883 PF05957.13 EXF86109.1 - 2.9 8.6 13.9 0.98 10.1 5.3 2.8 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) Lipoprotein_6 PF01441.19 EXF86109.1 - 3.3 7.7 11.7 7.7 6.5 0.6 2.4 1 1 1 2 2 2 0 Lipoprotein BST2 PF16716.5 EXF86109.1 - 3.4 8.3 18.0 3.2 8.4 0.7 3.4 1 1 1 3 3 3 0 Bone marrow stromal antigen 2 Takusan PF04822.13 EXF86109.1 - 4.2 7.3 12.1 5 7.1 6.4 3.3 1 1 2 3 3 3 0 Takusan zf-C4H2 PF10146.9 EXF86109.1 - 5.7 7.2 16.7 13 6.1 16.3 1.9 1 1 1 2 2 2 0 Zinc finger-containing protein Jnk-SapK_ap_N PF09744.9 EXF86109.1 - 6.5 7.0 24.0 4.8 7.4 15.3 2.3 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 Tom22 PF04281.13 EXF86110.1 - 3.6e-43 146.7 0.0 4.4e-43 146.4 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial import receptor subunit Tom22 DUF572 PF04502.13 EXF86112.1 - 0.00093 18.9 1.9 0.0015 18.2 1.9 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF572) DUF2461 PF09365.10 EXF86112.1 - 0.012 15.6 4.7 0.033 14.2 0.0 2.2 2 0 0 2 2 2 0 Conserved hypothetical protein (DUF2461) SANT_DAMP1_like PF16282.5 EXF86114.1 - 4.2e-31 107.0 0.2 8.9e-31 105.9 0.2 1.6 1 0 0 1 1 1 1 SANT/Myb-like domain of DAMP1 DUF809 PF05663.11 EXF86114.1 - 0.0066 16.6 0.2 0.0066 16.6 0.2 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF809) EMP24_GP25L PF01105.24 EXF86115.1 - 6.5e-53 179.4 0.0 7.3e-53 179.2 0.0 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD HXXSHH PF07586.11 EXF86115.1 - 0.095 12.3 0.2 0.15 11.7 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1552) Thymosin PF01290.20 EXF86115.1 - 0.12 12.1 0.0 0.22 11.3 0.0 1.4 1 0 0 1 1 1 0 Thymosin beta-4 family PPR_2 PF13041.6 EXF86116.1 - 6.9e-21 74.2 0.0 1.6e-06 28.2 0.0 5.4 4 1 1 5 5 5 4 PPR repeat family PPR_1 PF12854.7 EXF86116.1 - 4.5e-19 67.8 0.0 2.1e-05 24.1 0.0 5.5 5 0 0 5 5 5 4 PPR repeat PPR_3 PF13812.6 EXF86116.1 - 2.1e-12 46.9 0.0 4.4e-05 23.5 0.0 3.2 3 0 0 3 3 3 2 Pentatricopeptide repeat domain PPR PF01535.20 EXF86116.1 - 4.6e-12 45.3 0.5 0.013 15.7 0.0 5.6 5 1 0 5 5 5 3 PPR repeat PPR_long PF17177.4 EXF86116.1 - 7e-06 25.6 0.0 0.044 13.1 0.0 2.9 3 1 0 3 3 3 2 Pentacotripeptide-repeat region of PRORP Peptidase_S21 PF00716.17 EXF86116.1 - 0.17 11.6 0.2 14 5.2 0.0 2.2 2 0 0 2 2 2 0 Assemblin (Peptidase family S21) cwf18 PF08315.12 EXF86117.1 - 1.2e-45 155.5 7.5 1.2e-45 155.5 7.5 1.8 2 0 0 2 2 2 1 cwf18 pre-mRNA splicing factor TraI PF07057.11 EXF86117.1 - 0.083 13.0 0.0 0.18 11.9 0.0 1.6 1 0 0 1 1 1 0 DNA helicase TraI Pam16 PF03656.13 EXF86117.1 - 0.31 11.1 3.7 0.34 10.9 1.9 2.0 1 1 1 2 2 2 0 Pam16 zf-CCHC_3 PF13917.6 EXF86118.1 - 1.6e-13 50.4 6.2 4.1e-10 39.4 1.1 2.7 2 0 0 2 2 2 2 Zinc knuckle SUZ PF12752.7 EXF86119.1 - 8.3e-16 58.5 4.8 8.3e-16 58.5 4.8 3.4 3 1 0 3 3 3 1 SUZ domain R3H PF01424.22 EXF86119.1 - 2.9e-08 33.6 0.0 7.2e-08 32.3 0.0 1.7 1 0 0 1 1 1 1 R3H domain MitMem_reg PF13012.6 EXF86120.1 - 8.1e-18 64.9 0.3 1.7e-17 63.8 0.1 1.6 2 0 0 2 2 2 1 Maintenance of mitochondrial structure and function JAB PF01398.21 EXF86120.1 - 3e-15 56.2 0.0 5.5e-15 55.4 0.0 1.3 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease UTP25 PF06862.12 EXF86121.1 - 1.1e-197 657.5 0.4 1.6e-197 657.0 0.4 1.2 1 0 0 1 1 1 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 DEAD PF00270.29 EXF86121.1 - 0.015 15.1 0.1 0.44 10.3 0.1 2.2 1 1 0 1 1 1 0 DEAD/DEAH box helicase Ribosomal_L17 PF01196.19 EXF86122.1 - 1.6e-32 112.3 1.3 1.9e-32 112.0 0.1 1.7 2 0 0 2 2 2 1 Ribosomal protein L17 Mrpl_C PF18502.1 EXF86122.1 - 0.17 12.2 1.5 0.2 11.9 0.4 1.7 2 0 0 2 2 2 0 54S ribosomal protein L8 C-terminal domain AIM5 PF17050.5 EXF86123.1 - 3.3e-19 69.5 4.6 3.3e-19 69.5 4.6 2.2 2 0 0 2 2 2 1 Altered inheritance of mitochondria 5 Borrelia_P83 PF05262.11 EXF86123.1 - 0.0095 14.5 7.6 0.011 14.3 7.6 1.1 1 0 0 1 1 1 1 Borrelia P83/100 protein Aldedh PF00171.22 EXF86125.1 - 2.3e-83 280.2 0.0 2.7e-83 280.1 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family MRP-S28 PF10213.9 EXF86126.1 - 3.1e-48 163.4 0.8 3.1e-48 163.4 0.8 1.6 2 0 0 2 2 2 1 Mitochondrial ribosomal subunit protein CDC13_N PF16853.5 EXF86126.1 - 0.42 10.1 1.7 0.34 10.4 0.3 1.5 2 0 0 2 2 2 0 Cell division control protein 13 N-terminus DUF1682 PF07946.14 EXF86126.1 - 1 8.5 7.3 2 7.5 7.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Ank_2 PF12796.7 EXF86127.1 - 1.5e-56 189.0 3.7 1.2e-11 45.1 0.0 7.3 3 2 3 7 7 7 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EXF86127.1 - 1.6e-44 149.7 1.5 7.9e-07 29.5 0.0 9.8 6 3 4 10 10 10 9 Ankyrin repeats (many copies) Ank_3 PF13606.6 EXF86127.1 - 5.6e-34 112.3 2.1 0.0028 18.0 0.0 11.7 11 0 0 11 11 11 7 Ankyrin repeat Ank_5 PF13857.6 EXF86127.1 - 3.3e-31 106.9 11.4 9.3e-08 32.2 0.3 9.7 5 2 4 10 10 10 7 Ankyrin repeats (many copies) Ank PF00023.30 EXF86127.1 - 2.6e-30 103.5 11.6 0.026 15.0 0.0 11.6 13 0 0 13 13 13 7 Ankyrin repeat AAA_16 PF13191.6 EXF86127.1 - 4.4e-05 23.9 1.0 0.00025 21.5 0.1 2.7 2 0 0 2 2 2 1 AAA ATPase domain Abhydrolase_6 PF12697.7 EXF86127.1 - 4.6e-05 24.1 0.0 4.6e-05 24.1 0.0 2.9 2 1 0 2 2 1 1 Alpha/beta hydrolase family AAA_22 PF13401.6 EXF86127.1 - 0.00016 22.0 0.0 0.00055 20.2 0.0 1.9 1 0 0 1 1 1 1 AAA domain DUF676 PF05057.14 EXF86127.1 - 0.00076 19.1 0.0 0.0017 17.9 0.0 1.5 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Hydrolase_4 PF12146.8 EXF86127.1 - 0.0066 15.7 0.0 0.016 14.5 0.0 1.6 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Cutinase PF01083.22 EXF86127.1 - 0.0068 16.4 0.1 0.064 13.2 0.0 2.4 2 0 0 2 2 2 1 Cutinase PGAP1 PF07819.13 EXF86127.1 - 0.01 15.5 0.0 0.022 14.5 0.0 1.5 1 0 0 1 1 1 0 PGAP1-like protein Thioesterase PF00975.20 EXF86127.1 - 0.062 13.4 0.0 1.1 9.3 0.0 2.6 2 0 0 2 2 2 0 Thioesterase domain Lipase_3 PF01764.25 EXF86127.1 - 0.093 12.6 0.0 0.25 11.2 0.0 1.7 1 0 0 1 1 1 0 Lipase (class 3) BUD22 PF09073.10 EXF86127.1 - 1.1 8.5 29.3 0.11 11.9 11.9 2.4 2 0 0 2 2 2 0 BUD22 Glyco_tran_28_C PF04101.16 EXF86129.1 - 3.6e-19 69.3 0.0 8.2e-19 68.2 0.0 1.5 1 1 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain K_channel_TID PF07941.11 EXF86129.1 - 0.97 9.9 8.8 0.16 12.5 4.8 1.7 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain WD40 PF00400.32 EXF86130.1 - 8.8e-28 96.0 39.4 8.9e-05 23.2 0.3 10.6 11 0 0 11 11 11 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EXF86130.1 - 3e-15 56.3 7.4 0.0002 21.6 0.1 6.4 5 2 2 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 EXF86130.1 - 1.3e-05 25.0 0.5 5.9 7.0 0.0 4.4 4 0 0 4 4 4 3 WD40-like Beta Propeller Repeat Nbas_N PF15492.6 EXF86130.1 - 0.00013 21.4 1.1 0.8 9.0 0.2 3.5 2 1 0 3 3 3 2 Neuroblastoma-amplified sequence, N terminal Ge1_WD40 PF16529.5 EXF86130.1 - 0.00099 18.2 4.8 0.21 10.5 0.2 4.1 3 1 1 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 EXF86130.1 - 0.0047 16.8 0.4 3.4 7.5 0.0 3.9 3 2 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A CPSF_A PF03178.15 EXF86130.1 - 0.0073 15.7 0.0 0.042 13.2 0.0 2.1 2 0 0 2 2 2 1 CPSF A subunit region SNF2_N PF00176.23 EXF86131.1 - 9.8e-77 258.0 0.1 2e-76 257.0 0.1 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain SLIDE PF09111.10 EXF86131.1 - 2.4e-42 143.5 1.5 2.4e-42 143.5 1.5 2.7 2 0 0 2 2 2 1 SLIDE HAND PF09110.11 EXF86131.1 - 1.8e-34 118.8 6.0 1.8e-34 118.8 6.0 4.4 4 0 0 4 4 4 1 HAND Helicase_C PF00271.31 EXF86131.1 - 2.8e-18 66.3 0.6 1.4e-17 64.0 0.0 2.6 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EXF86131.1 - 5.5e-11 42.8 0.1 3.9e-10 40.0 0.0 2.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Myb_DNA-binding PF00249.31 EXF86131.1 - 4.1e-05 23.7 0.0 0.071 13.3 0.0 3.0 2 0 0 2 2 2 2 Myb-like DNA-binding domain HDA2-3 PF11496.8 EXF86131.1 - 0.00013 21.3 0.0 0.00048 19.4 0.0 2.0 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 DEAD PF00270.29 EXF86131.1 - 0.00037 20.3 0.0 0.0017 18.1 0.0 2.2 3 0 0 3 3 3 1 DEAD/DEAH box helicase DUF1086 PF06461.11 EXF86131.1 - 0.00054 19.8 0.1 0.0014 18.5 0.1 1.6 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1086) Occludin_ELL PF07303.13 EXF86131.1 - 0.08 13.7 4.5 0.31 11.8 4.5 2.0 1 0 0 1 1 1 0 Occludin homology domain DUF4588 PF15251.6 EXF86132.1 - 9.7e-09 35.4 1.1 1.8e-08 34.5 1.1 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF4588) Cytochrom_B562 PF07361.11 EXF86132.1 - 0.033 14.9 0.0 0.056 14.1 0.0 1.4 1 0 0 1 1 1 0 Cytochrome b562 WD40 PF00400.32 EXF86133.1 - 7.5e-23 80.4 0.2 8.7e-08 32.7 0.2 5.8 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EXF86133.1 - 5.7e-13 49.0 0.0 0.0083 16.4 0.0 4.9 2 2 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EXF86133.1 - 0.0026 17.7 0.1 3.3 7.5 0.0 2.8 2 2 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 EXF86133.1 - 0.0046 16.3 0.0 0.14 11.4 0.0 2.7 1 1 1 2 2 2 1 WD40-like domain Coatomer_WDAD PF04053.14 EXF86133.1 - 0.014 14.5 0.1 0.16 10.9 0.0 2.0 1 1 0 2 2 2 0 Coatomer WD associated region PQQ_2 PF13360.6 EXF86133.1 - 0.017 14.7 0.0 0.38 10.3 0.0 2.3 1 1 0 1 1 1 0 PQQ-like domain Nup160 PF11715.8 EXF86133.1 - 0.036 12.7 0.0 0.048 12.3 0.0 1.2 1 0 0 1 1 1 0 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 EXF86133.1 - 0.046 12.5 0.0 0.058 12.1 0.0 1.2 1 0 0 1 1 1 0 Nup133 N terminal like FTHFS PF01268.19 EXF86134.1 - 4.7e-254 843.7 0.1 6.8e-254 843.2 0.1 1.2 1 0 0 1 1 1 1 Formate--tetrahydrofolate ligase THF_DHG_CYH_C PF02882.19 EXF86134.1 - 8.9e-67 223.4 2.8 9.9e-67 223.2 0.7 2.0 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.23 EXF86134.1 - 5.1e-38 129.9 0.5 1.2e-37 128.7 0.5 1.7 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain Glyco_trans_1_4 PF13692.6 EXF86134.1 - 0.036 14.5 0.0 0.19 12.1 0.1 2.3 2 0 0 2 2 2 0 Glycosyl transferases group 1 OCD_Mu_crystall PF02423.15 EXF86134.1 - 0.065 12.2 0.6 0.12 11.2 0.1 1.6 2 0 0 2 2 2 0 Ornithine cyclodeaminase/mu-crystallin family GTP_EFTU PF00009.27 EXF86134.1 - 0.16 11.5 0.0 0.42 10.1 0.0 1.7 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain Asp PF00026.23 EXF86136.1 - 1.3e-49 169.3 0.0 2.3e-49 168.5 0.0 1.4 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EXF86136.1 - 6.3e-12 46.1 0.2 6.3e-12 46.1 0.2 2.5 3 1 0 3 3 3 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EXF86136.1 - 0.011 16.4 0.1 3.4 8.4 0.0 3.2 2 0 0 2 2 2 0 Aspartyl protease gag-asp_proteas PF13975.6 EXF86136.1 - 0.018 15.6 0.2 2.8 8.5 0.0 3.1 2 1 0 2 2 2 0 gag-polyprotein putative aspartyl protease ATP12 PF07542.11 EXF86138.1 - 9e-42 142.2 0.1 1.6e-41 141.4 0.1 1.4 1 0 0 1 1 1 1 ATP12 chaperone protein Pkinase PF00069.25 EXF86141.1 - 3.3e-60 203.7 0.0 4.3e-59 200.0 0.0 2.3 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF86141.1 - 1.8e-28 99.6 0.6 1.9e-19 70.0 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_C PF00433.24 EXF86141.1 - 0.0011 19.6 1.5 0.0011 19.6 1.5 2.3 2 0 0 2 2 2 1 Protein kinase C terminal domain Kinase-like PF14531.6 EXF86141.1 - 0.0065 15.8 0.1 0.025 13.9 0.0 1.9 3 0 0 3 3 3 1 Kinase-like APH PF01636.23 EXF86141.1 - 0.0077 16.2 0.1 0.11 12.5 0.1 2.4 1 1 1 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EXF86141.1 - 0.034 13.1 0.0 0.07 12.1 0.0 1.4 1 1 0 1 1 1 0 Haspin like kinase domain Kdo PF06293.14 EXF86141.1 - 0.036 13.4 0.0 0.068 12.5 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Wbp11 PF09429.10 EXF86142.1 - 3.7e-23 81.7 8.6 3.7e-23 81.7 8.6 2.7 2 1 0 2 2 2 1 WW domain binding protein 11 PAG PF15347.6 EXF86142.1 - 0.032 13.3 2.6 0.043 12.8 2.6 1.2 1 0 0 1 1 1 0 Phosphoprotein associated with glycosphingolipid-enriched SHR3_chaperone PF08229.11 EXF86142.1 - 4.3 6.3 6.1 8.1 5.4 6.1 1.4 1 0 0 1 1 1 0 ER membrane protein SH3 bZIP_2 PF07716.15 EXF86143.1 - 2.5e-07 30.7 5.1 3.7e-07 30.1 5.1 1.3 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 EXF86143.1 - 0.0035 17.8 3.7 0.0075 16.8 3.7 1.5 1 0 0 1 1 1 1 bZIP Maf transcription factor bZIP_1 PF00170.21 EXF86143.1 - 0.0047 17.0 4.7 0.0075 16.3 4.7 1.3 1 0 0 1 1 1 1 bZIP transcription factor Zn_clus PF00172.18 EXF86144.1 - 4e-09 36.4 7.7 6.3e-09 35.8 7.7 1.2 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CCAP PF11105.8 EXF86144.1 - 0.033 14.1 2.1 0.18 11.7 2.1 2.1 1 1 0 1 1 1 0 Arthropod cardioacceleratory peptide 2a DUF4778 PF16008.5 EXF86144.1 - 0.071 13.2 0.0 0.096 12.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4778) Clusterin PF01093.17 EXF86144.1 - 0.075 12.1 0.1 0.094 11.7 0.1 1.1 1 0 0 1 1 1 0 Clusterin Velvet PF11754.8 EXF86147.1 - 2.7e-53 181.5 0.2 6.5e-35 121.3 0.0 3.6 2 2 1 3 3 3 2 Velvet factor FAD_binding_7 PF03441.14 EXF86148.1 - 5.8e-77 257.7 1.3 8.4e-77 257.2 1.3 1.2 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.18 EXF86148.1 - 2e-35 122.2 0.0 6.2e-35 120.6 0.0 1.8 2 0 0 2 2 2 1 DNA photolyase ubiquitin PF00240.23 EXF86149.1 - 0.11 12.2 0.0 0.5 10.2 0.0 2.0 2 0 0 2 2 2 0 Ubiquitin family CM2 PF03021.14 EXF86149.1 - 0.15 11.9 0.1 0.55 10.1 0.0 1.9 2 0 0 2 2 2 0 Influenza C virus M2 protein PhyH PF05721.13 EXF86150.1 - 1.5e-31 110.4 0.0 1.9e-31 110.0 0.0 1.2 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) Telethonin PF09470.10 EXF86153.1 - 0.065 13.1 0.1 0.12 12.3 0.1 1.5 1 0 0 1 1 1 0 Telethonin protein ABC_membrane PF00664.23 EXF86155.1 - 3e-102 342.0 45.8 2.5e-55 188.1 19.3 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EXF86155.1 - 1.5e-66 223.1 0.0 3.9e-32 111.6 0.0 2.7 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EXF86155.1 - 2.2e-14 53.4 0.0 7.8e-06 25.5 0.0 3.2 2 1 1 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 EXF86155.1 - 6.5e-09 36.4 0.9 0.0042 17.5 0.0 2.9 2 1 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 EXF86155.1 - 3.8e-08 33.4 0.0 0.028 14.3 0.0 3.6 3 0 0 3 3 3 2 RsgA GTPase AAA_29 PF13555.6 EXF86155.1 - 7.4e-07 28.8 2.2 0.0027 17.4 0.4 3.3 3 0 0 3 3 3 2 P-loop containing region of AAA domain AAA_15 PF13175.6 EXF86155.1 - 7.3e-05 22.6 0.3 0.45 10.2 0.0 2.6 3 0 0 3 3 2 2 AAA ATPase domain AAA_22 PF13401.6 EXF86155.1 - 0.00018 21.8 1.1 0.26 11.5 0.0 3.3 2 2 0 2 2 2 2 AAA domain AAA PF00004.29 EXF86155.1 - 0.00027 21.4 2.0 5 7.6 0.1 4.4 3 1 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) ABC_ATPase PF09818.9 EXF86155.1 - 0.00041 19.3 3.0 0.17 10.6 0.0 3.0 3 0 0 3 3 3 2 Predicted ATPase of the ABC class AAA_21 PF13304.6 EXF86155.1 - 0.00058 19.8 0.2 1.7 8.4 0.0 3.2 2 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_25 PF13481.6 EXF86155.1 - 0.00084 19.0 5.2 0.19 11.3 0.0 3.4 4 0 0 4 4 3 2 AAA domain Zeta_toxin PF06414.12 EXF86155.1 - 0.0012 18.1 0.0 1.5 8.0 0.0 2.8 2 0 0 2 2 2 2 Zeta toxin AAA_30 PF13604.6 EXF86155.1 - 0.0019 18.0 2.7 2.2 8.0 0.1 3.8 4 1 0 4 4 3 2 AAA domain SbcCD_C PF13558.6 EXF86155.1 - 0.0024 18.1 1.2 4 7.7 0.2 3.6 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit G-alpha PF00503.20 EXF86155.1 - 0.005 16.0 0.0 2.8 7.0 0.0 2.4 2 0 0 2 2 2 2 G-protein alpha subunit AAA_28 PF13521.6 EXF86155.1 - 0.0069 16.6 0.7 0.57 10.4 0.1 2.7 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EXF86155.1 - 0.0077 16.4 0.0 5.3 7.2 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 EXF86155.1 - 0.0081 15.7 0.0 3.5 7.1 0.0 2.5 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_5 PF07728.14 EXF86155.1 - 0.0094 16.0 0.1 12 5.9 0.0 3.4 3 0 0 3 3 2 0 AAA domain (dynein-related subfamily) DUF87 PF01935.17 EXF86155.1 - 0.021 14.9 2.0 5.3 7.1 0.1 2.9 3 0 0 3 3 2 0 Helicase HerA, central domain AAA_23 PF13476.6 EXF86155.1 - 0.025 15.1 0.6 3.1 8.3 0.0 3.1 3 0 0 3 3 3 0 AAA domain AAA_18 PF13238.6 EXF86155.1 - 0.031 14.8 0.0 14 6.3 0.0 2.9 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 EXF86155.1 - 0.12 12.1 0.1 7.3 6.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain APS_kinase PF01583.20 EXF86155.1 - 0.13 12.2 0.1 3.7 7.4 0.0 2.7 2 0 0 2 2 2 0 Adenylylsulphate kinase MMR_HSR1 PF01926.23 EXF86155.1 - 1.3 9.1 5.0 6.8 6.8 0.0 3.3 3 0 0 3 3 3 0 50S ribosome-binding GTPase Fic PF02661.18 EXF86156.1 - 1.5e-13 51.5 0.0 3e-13 50.5 0.0 1.5 1 0 0 1 1 1 1 Fic/DOC family SARAF PF06682.12 EXF86157.1 - 3.9e-103 345.6 3.6 4.5e-103 345.4 3.6 1.0 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis BRE1 PF08647.11 EXF86158.1 - 1.2e-22 79.7 8.8 1.2e-22 79.7 8.8 6.8 4 2 2 6 6 6 2 BRE1 E3 ubiquitin ligase JIP_LZII PF16471.5 EXF86158.1 - 0.00049 20.2 2.0 0.00049 20.2 2.0 7.1 7 1 1 8 8 8 2 JNK-interacting protein leucine zipper II DivIC PF04977.15 EXF86158.1 - 0.0023 17.7 1.9 0.0023 17.7 1.9 10.1 7 3 3 10 10 10 3 Septum formation initiator DUF1664 PF07889.12 EXF86158.1 - 0.0035 17.4 1.9 0.0035 17.4 1.9 6.1 6 2 1 7 7 7 1 Protein of unknown function (DUF1664) TPR_MLP1_2 PF07926.12 EXF86158.1 - 0.0038 17.3 9.5 0.0038 17.3 9.5 7.2 3 2 3 7 7 7 2 TPR/MLP1/MLP2-like protein ATG16 PF08614.11 EXF86158.1 - 0.0079 16.4 16.9 0.0079 16.4 16.9 5.8 3 2 2 5 5 5 2 Autophagy protein 16 (ATG16) bZIP_1 PF00170.21 EXF86158.1 - 0.013 15.5 1.3 0.013 15.5 1.3 8.6 8 2 4 12 12 12 0 bZIP transcription factor DUF2935 PF11155.8 EXF86158.1 - 3.8 7.9 11.0 2.1e+02 2.2 0.1 5.0 2 2 0 2 2 2 0 Domain of unknown function (DUF2935) MRP-S23 PF10484.9 EXF86158.1 - 4.3 7.6 9.3 26 5.1 0.1 4.1 3 1 1 4 4 4 0 Mitochondrial ribosomal protein S23 Myb_DNA-bind_7 PF15963.5 EXF86159.1 - 3.4e-24 84.5 0.2 3.4e-24 84.5 0.2 1.9 2 0 0 2 2 2 1 Myb DNA-binding like Myb_DNA-binding PF00249.31 EXF86159.1 - 6.1e-05 23.1 0.0 0.00011 22.3 0.0 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EXF86159.1 - 0.079 13.2 0.0 0.19 12.0 0.0 1.7 1 1 0 1 1 1 0 Myb-like DNA-binding domain XPC-binding PF09280.11 EXF86160.1 - 2.1e-24 85.0 16.1 3.5e-24 84.3 16.1 1.4 1 0 0 1 1 1 1 XPC-binding domain UBA PF00627.31 EXF86160.1 - 2.2e-23 81.8 9.2 3e-13 49.4 0.5 2.8 2 0 0 2 2 2 2 UBA/TS-N domain ubiquitin PF00240.23 EXF86160.1 - 8e-21 73.6 0.2 1.5e-20 72.7 0.2 1.4 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EXF86160.1 - 1.7e-08 34.2 0.6 2.9e-08 33.4 0.6 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like UBA_3 PF09288.10 EXF86160.1 - 0.0026 17.5 0.0 1.3 8.9 0.0 2.4 2 0 0 2 2 2 2 Fungal ubiquitin-associated domain MCM_N PF14551.6 EXF86160.1 - 0.016 15.8 0.1 0.036 14.7 0.1 1.6 1 0 0 1 1 1 0 MCM N-terminal domain Clathrin_H_link PF13838.6 EXF86160.1 - 0.02 14.8 3.1 0.02 14.8 3.1 2.4 2 0 0 2 2 2 0 Clathrin-H-link Rad60-SLD_2 PF13881.6 EXF86160.1 - 0.023 14.8 0.0 0.049 13.7 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Rib_recp_KP_reg PF05104.12 EXF86160.1 - 0.24 12.4 17.4 0.061 14.4 12.8 2.2 2 0 0 2 2 2 0 Ribosome receptor lysine/proline rich region DAGK_cat PF00781.24 EXF86162.1 - 3.9e-08 33.0 0.0 1.5e-07 31.1 0.0 2.0 1 1 0 1 1 1 1 Diacylglycerol kinase catalytic domain TRM PF02005.16 EXF86163.1 - 2e-106 356.4 0.0 3.4e-93 312.8 0.0 2.1 2 0 0 2 2 2 2 N2,N2-dimethylguanosine tRNA methyltransferase FixO PF02433.15 EXF86163.1 - 0.17 11.3 0.9 0.4 10.1 0.9 1.6 1 0 0 1 1 1 0 Cytochrome C oxidase, mono-heme subunit/FixO SUN PF03856.13 EXF86164.1 - 0.0095 15.4 0.1 0.012 15.1 0.1 1.1 1 0 0 1 1 1 1 Beta-glucosidase (SUN family) tRNA-synt_1d PF00750.19 EXF86166.1 - 1.6e-62 211.5 0.0 2.3e-62 211.0 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.15 EXF86166.1 - 3.1e-13 49.9 0.2 6e-13 49.0 0.2 1.5 1 0 0 1 1 1 1 DALR anticodon binding domain Tautomerase_2 PF14552.6 EXF86167.1 - 0.4 10.8 1.4 1.1 9.4 0.0 2.3 2 0 0 2 2 2 0 Tautomerase enzyme RhodobacterPufX PF11511.8 EXF86168.1 - 0.23 11.1 3.9 0.69 9.6 3.9 1.8 1 0 0 1 1 1 0 Intrinsic membrane protein PufX FAD_binding_4 PF01565.23 EXF86169.1 - 5.4e-22 78.0 4.1 1e-21 77.1 4.1 1.5 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EXF86169.1 - 1.4e-11 44.3 0.4 3.5e-11 43.0 0.4 1.8 1 0 0 1 1 1 1 Berberine and berberine like Glyco_hydro_39 PF01229.17 EXF86170.1 - 6.2e-05 21.8 0.1 8.9e-05 21.3 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 39 BatD PF13584.6 EXF86170.1 - 0.032 13.1 0.0 0.043 12.6 0.0 1.1 1 0 0 1 1 1 0 Oxygen tolerance Sugar_tr PF00083.24 EXF86171.1 - 1.1e-89 301.4 19.6 1.3e-89 301.2 19.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF86171.1 - 2.6e-20 72.6 30.5 2.6e-20 72.6 30.5 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 EXF86171.1 - 4.1e-05 22.6 3.4 4.1e-05 22.6 3.4 1.6 2 0 0 2 2 2 1 MFS_1 like family OppC_N PF12911.7 EXF86171.1 - 0.51 10.3 4.2 1.5 8.9 1.3 2.8 2 0 0 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C Fungal_trans PF04082.18 EXF86172.1 - 4.6e-10 39.0 0.0 8.4e-10 38.1 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2_6 PF13912.6 EXF86172.1 - 4.2e-09 36.2 7.5 0.00059 19.8 2.7 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 EXF86172.1 - 5.2e-09 36.1 9.5 0.00037 20.8 3.9 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EXF86172.1 - 3.8e-08 33.4 11.0 5.1e-07 29.8 3.8 3.2 3 0 0 3 3 3 2 Zinc-finger double domain Zn_clus PF00172.18 EXF86172.1 - 1e-05 25.5 12.4 1e-05 25.5 12.4 2.0 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-C2H2_4 PF13894.6 EXF86172.1 - 0.00051 20.6 16.4 0.012 16.3 2.6 3.3 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EXF86172.1 - 0.45 10.9 9.0 0.81 10.0 0.6 2.8 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-C2HE PF16278.5 EXF86172.1 - 1.2 9.6 4.5 2.1 8.9 0.7 2.5 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger Fungal_trans PF04082.18 EXF86173.1 - 5.3e-18 65.0 0.0 8.9e-18 64.3 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain ADH_zinc_N PF00107.26 EXF86174.1 - 1.5e-10 41.2 0.0 2.3e-10 40.6 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EXF86174.1 - 7.5e-05 23.8 0.0 0.00012 23.2 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EXF86174.1 - 0.00026 20.8 0.0 0.00046 20.1 0.0 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Glyco_hydro_61 PF03443.14 EXF86175.1 - 4.9e-58 196.4 0.3 7.1e-58 195.9 0.3 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 CBM_1 PF00734.18 EXF86175.1 - 5.8e-10 38.9 15.0 1.6e-09 37.5 15.0 1.8 1 0 0 1 1 1 1 Fungal cellulose binding domain Wzy_C PF04932.15 EXF86176.1 - 4.2 7.0 7.0 0.66 9.6 0.2 2.5 2 1 1 3 3 3 0 O-Antigen ligase LANC_like PF05147.13 EXF86177.1 - 9.8e-20 70.4 0.0 5.2e-19 68.0 0.0 1.9 1 1 0 1 1 1 1 Lanthionine synthetase C-like protein LPMO_10 PF03067.15 EXF86178.1 - 3.3e-09 37.7 0.1 5.2e-09 37.0 0.1 1.3 1 0 0 1 1 1 1 Lytic polysaccharide mono-oxygenase, cellulose-degrading Acyl-CoA_dh_1 PF00441.24 EXF86179.1 - 3.3e-31 108.5 0.2 5.3e-31 107.9 0.2 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 EXF86179.1 - 4.9e-24 84.4 0.1 8.3e-24 83.6 0.1 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 EXF86179.1 - 1.2e-12 48.5 0.5 4.7e-11 43.3 0.1 2.8 2 1 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain CFEM PF05730.11 EXF86180.1 - 1e-13 51.1 8.8 1.7e-13 50.4 8.8 1.4 1 0 0 1 1 1 1 CFEM domain Pyr_redox_3 PF13738.6 EXF86181.1 - 1.9e-11 43.8 0.0 7.5e-08 32.0 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 EXF86181.1 - 1.9e-10 39.8 0.0 6.6e-10 38.0 0.0 1.8 2 0 0 2 2 2 1 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 EXF86181.1 - 6.7e-10 38.7 0.0 1.9e-08 33.9 0.0 2.4 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EXF86181.1 - 3e-08 33.8 0.0 8.7e-07 29.1 0.0 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EXF86181.1 - 3.3e-08 33.5 0.1 2.9e-05 23.8 0.0 3.7 4 0 0 4 4 4 1 FAD dependent oxidoreductase K_oxygenase PF13434.6 EXF86181.1 - 4.1e-07 29.5 0.0 5e-05 22.6 0.0 2.3 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Thi4 PF01946.17 EXF86181.1 - 0.00012 21.4 0.0 0.018 14.3 0.0 2.3 2 0 0 2 2 2 2 Thi4 family Pyr_redox PF00070.27 EXF86181.1 - 0.00046 20.7 0.0 4.5 7.9 0.0 3.4 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EXF86181.1 - 0.0043 16.2 0.0 2 7.4 0.0 3.0 4 0 0 4 4 4 2 FAD binding domain Amino_oxidase PF01593.24 EXF86181.1 - 0.0061 15.9 0.0 0.0085 15.4 0.0 1.2 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_9 PF13454.6 EXF86181.1 - 0.028 14.4 2.2 3 7.8 0.0 3.5 4 0 0 4 4 4 0 FAD-NAD(P)-binding Shikimate_DH PF01488.20 EXF86181.1 - 0.1 12.7 0.0 2 8.5 0.0 2.3 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Lactamase_B PF00753.27 EXF86182.1 - 2.8e-07 30.8 0.0 5.7e-07 29.7 0.0 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EXF86182.1 - 3.5e-06 26.7 0.9 0.00011 21.8 0.9 2.4 1 1 0 1 1 1 1 Beta-lactamase superfamily domain RMMBL PF07521.12 EXF86182.1 - 0.18 11.8 0.2 0.52 10.3 0.0 1.9 2 0 0 2 2 2 0 Zn-dependent metallo-hydrolase RNA specificity domain Cu_amine_oxid PF01179.20 EXF86184.1 - 3.9e-163 543.2 0.0 4.8e-163 542.8 0.0 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN3 PF02728.16 EXF86184.1 - 1.4e-22 80.0 0.2 3e-22 78.9 0.2 1.6 1 0 0 1 1 1 1 Copper amine oxidase, N3 domain Cu_amine_oxidN2 PF02727.16 EXF86184.1 - 4.4e-15 55.7 0.0 8.2e-15 54.8 0.0 1.5 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain MFS_1 PF07690.16 EXF86186.1 - 1.5e-35 122.8 30.9 2.2e-35 122.2 30.9 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Pex14_N PF04695.13 EXF86187.1 - 0.011 16.4 7.6 0.011 16.4 7.6 3.0 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region EBP50_C PF09007.11 EXF86187.1 - 1.6 9.8 10.2 0.077 14.0 2.0 2.6 2 1 0 2 2 2 0 EBP50, C-terminal RTA1 PF04479.13 EXF86188.1 - 1.2e-65 221.0 8.5 1.9e-65 220.4 8.5 1.2 1 0 0 1 1 1 1 RTA1 like protein DUF3382 PF11862.8 EXF86188.1 - 0.95 9.8 4.1 0.44 10.9 0.3 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF3382) DUF3176 PF11374.8 EXF86189.1 - 5.6e-34 116.6 3.0 4.2e-33 113.8 0.4 2.7 3 0 0 3 3 3 1 Protein of unknown function (DUF3176) THOC2_N PF16134.5 EXF86189.1 - 0.0074 15.0 0.0 0.01 14.5 0.0 1.1 1 0 0 1 1 1 1 THO complex subunit 2 N-terminus Fungal_trans PF04082.18 EXF86190.1 - 7.2e-11 41.6 0.1 1.2e-10 40.9 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain UPF0172 PF03665.13 EXF86190.1 - 0.17 11.9 0.3 0.36 10.9 0.0 1.6 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0172) Corazonin PF17308.2 EXF86190.1 - 0.27 11.6 2.0 0.31 11.4 0.4 1.9 2 0 0 2 2 2 0 Pro-corazonin Lipase_GDSL PF00657.22 EXF86191.1 - 2.8e-08 34.0 0.0 3.3e-08 33.7 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.6 EXF86191.1 - 0.00091 19.7 5.0 0.0015 18.9 5.0 1.4 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Imm21 PF15589.6 EXF86191.1 - 0.1 12.6 1.5 0.22 11.6 1.5 1.6 1 1 0 1 1 1 0 Immunity protein 21 DUF4064 PF13273.6 EXF86192.1 - 6.6 7.1 27.1 1.9 8.8 1.5 5.1 3 2 1 4 4 4 0 Protein of unknown function (DUF4064) 4HBT PF03061.22 EXF86193.1 - 5.8e-14 52.2 0.0 8.3e-14 51.7 0.0 1.2 1 0 0 1 1 1 1 Thioesterase superfamily DUF4442 PF14539.6 EXF86193.1 - 0.0081 16.3 0.0 0.01 15.9 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4442) 4HBT_3 PF13622.6 EXF86193.1 - 0.017 15.4 0.0 0.017 15.3 0.0 1.1 1 0 0 1 1 1 0 Thioesterase-like superfamily Tfb2 PF03849.14 EXF86194.1 - 4.9e-134 446.8 0.0 5.8e-134 446.5 0.0 1.1 1 0 0 1 1 1 1 Transcription factor Tfb2 Tfb2_C PF18307.1 EXF86194.1 - 2.2e-21 76.0 0.1 4.2e-21 75.1 0.1 1.5 1 0 0 1 1 1 1 Transcription factor Tfb2 (p52) C-terminal domain Helicase_C_3 PF13625.6 EXF86194.1 - 7.4e-05 22.9 0.0 0.00017 21.8 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain TANGO2 PF05742.12 EXF86196.1 - 1.7e-69 234.7 0.0 2e-69 234.5 0.0 1.0 1 0 0 1 1 1 1 Transport and Golgi organisation 2 ABC_tran PF00005.27 EXF86197.1 - 4.3e-39 134.1 0.0 4.8e-18 66.0 0.0 2.7 3 0 0 3 3 2 2 ABC transporter ABC_membrane PF00664.23 EXF86197.1 - 1.6e-22 80.5 14.7 1.6e-22 80.5 14.7 3.4 3 1 0 3 3 3 2 ABC transporter transmembrane region AAA_21 PF13304.6 EXF86197.1 - 1.9e-10 41.0 3.8 0.00016 21.6 0.0 4.2 2 2 1 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EXF86197.1 - 6.3e-08 32.3 0.0 0.0055 16.2 0.0 3.9 3 1 0 4 4 4 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EXF86197.1 - 6.1e-06 25.9 0.1 0.097 12.4 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EXF86197.1 - 3.2e-05 23.9 0.1 0.17 11.8 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase AAA_22 PF13401.6 EXF86197.1 - 3.3e-05 24.2 0.0 0.12 12.7 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EXF86197.1 - 0.00026 21.4 0.3 0.34 11.3 0.1 2.6 2 0 0 2 2 2 2 AAA ATPase domain MMR_HSR1 PF01926.23 EXF86197.1 - 0.0016 18.5 0.2 1.1 9.3 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_7 PF12775.7 EXF86197.1 - 0.0019 17.8 0.0 0.24 10.9 0.0 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA PF00004.29 EXF86197.1 - 0.0046 17.4 0.0 1.8 9.0 0.0 3.0 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) T2SSE PF00437.20 EXF86197.1 - 0.0068 15.5 0.0 0.28 10.2 0.0 2.4 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_18 PF13238.6 EXF86197.1 - 0.017 15.7 0.0 4.6 7.8 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 EXF86197.1 - 0.017 15.3 0.0 1.3 9.2 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_15 PF13175.6 EXF86197.1 - 0.018 14.8 0.0 2.3 7.8 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain AAA_25 PF13481.6 EXF86197.1 - 0.025 14.2 0.1 8.1 6.0 0.0 2.6 2 0 0 2 2 2 0 AAA domain Dynamin_N PF00350.23 EXF86197.1 - 0.047 13.8 0.7 5.6 7.0 0.1 2.4 2 0 0 2 2 2 0 Dynamin family AAA_23 PF13476.6 EXF86197.1 - 0.074 13.5 0.0 9.4 6.7 0.0 2.3 2 0 0 2 2 2 0 AAA domain DUF4191 PF13829.6 EXF86197.1 - 9.8 5.4 7.4 1.4 8.2 0.9 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4191) PfkB PF00294.24 EXF86198.1 - 2e-08 33.9 0.0 2.6e-08 33.5 0.0 1.1 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Peptidase_S8 PF00082.22 EXF86199.1 - 9.4e-46 156.4 4.5 1.5e-45 155.8 4.5 1.3 1 0 0 1 1 1 1 Subtilase family fn3_5 PF06280.12 EXF86199.1 - 1.2e-06 29.2 1.1 6.2e-06 26.9 0.1 2.3 2 0 0 2 2 2 1 Fn3-like domain PA PF02225.22 EXF86199.1 - 7.2e-05 22.7 0.0 0.00025 21.0 0.0 1.9 1 0 0 1 1 1 1 PA domain DUF4232 PF14016.6 EXF86199.1 - 0.0092 16.1 0.4 0.042 14.0 0.4 2.1 1 0 0 1 1 1 1 Protein of unknown function (DUF4232) Fungal_trans_2 PF11951.8 EXF86202.1 - 2e-08 33.5 0.1 2.8e-08 33.0 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain CVNH PF08881.10 EXF86203.1 - 2.4e-09 37.8 0.1 4.5e-09 36.9 0.1 1.5 2 0 0 2 2 2 1 CVNH domain FAD_binding_3 PF01494.19 EXF86205.1 - 2e-22 79.9 0.0 3.1e-22 79.3 0.0 1.3 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.24 EXF86205.1 - 1.6e-09 37.8 1.3 9.8e-08 32.0 0.9 2.2 1 1 1 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EXF86205.1 - 1.1e-08 34.7 0.4 5.2e-05 22.6 0.1 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EXF86205.1 - 1e-05 25.7 0.1 2.4e-05 24.5 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 EXF86205.1 - 0.00031 20.2 0.0 0.056 12.7 0.0 2.2 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase Lycopene_cycl PF05834.12 EXF86205.1 - 0.00051 19.2 1.2 0.36 9.8 0.0 2.8 2 1 0 3 3 3 2 Lycopene cyclase protein GIDA PF01134.22 EXF86205.1 - 0.0015 17.7 0.0 0.002 17.3 0.0 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A AlaDh_PNT_C PF01262.21 EXF86205.1 - 0.0046 16.3 0.2 0.0089 15.3 0.2 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox PF00070.27 EXF86205.1 - 0.0047 17.5 0.2 0.11 13.0 0.1 2.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EXF86205.1 - 0.0055 15.6 0.4 0.14 10.9 0.2 2.1 2 0 0 2 2 2 1 Tryptophan halogenase SE PF08491.10 EXF86205.1 - 0.012 14.7 0.0 3 6.8 0.0 2.2 2 0 0 2 2 2 0 Squalene epoxidase FAD_binding_2 PF00890.24 EXF86205.1 - 0.016 14.4 0.6 0.023 13.8 0.6 1.2 1 0 0 1 1 1 0 FAD binding domain HI0933_like PF03486.14 EXF86205.1 - 0.024 13.4 0.1 0.047 12.4 0.1 1.4 1 0 0 1 1 1 0 HI0933-like protein NAD_binding_9 PF13454.6 EXF86205.1 - 0.044 13.8 0.7 2.2 8.3 0.0 3.1 3 0 0 3 3 3 0 FAD-NAD(P)-binding Pyr_redox_3 PF13738.6 EXF86205.1 - 0.062 12.5 0.0 1.3 8.2 0.1 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EXF86205.1 - 0.12 11.6 0.2 0.25 10.5 0.1 1.6 2 0 0 2 2 2 0 Thi4 family Fungal_trans PF04082.18 EXF86206.1 - 9.3e-08 31.4 0.6 1.5e-07 30.7 0.6 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain adh_short_C2 PF13561.6 EXF86207.1 - 8.6e-50 169.5 0.0 1.1e-49 169.1 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF86207.1 - 4.5e-46 156.8 0.0 5.4e-46 156.5 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EXF86207.1 - 6.9e-06 26.1 0.1 9.7e-06 25.6 0.1 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EXF86207.1 - 0.00057 19.4 0.0 0.0012 18.3 0.0 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF1776 PF08643.10 EXF86207.1 - 0.037 13.4 0.0 0.055 12.8 0.0 1.3 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) Beta-lactamase PF00144.24 EXF86208.1 - 2.2e-45 155.3 0.0 2.9e-45 155.0 0.0 1.1 1 0 0 1 1 1 1 Beta-lactamase Peptidase_S11 PF00768.20 EXF86208.1 - 0.041 13.3 0.0 1.7 8.0 0.0 2.2 2 0 0 2 2 2 0 D-alanyl-D-alanine carboxypeptidase Beta-lactamase2 PF13354.6 EXF86208.1 - 0.16 11.6 0.0 0.34 10.5 0.0 1.5 1 0 0 1 1 1 0 Beta-lactamase enzyme family DUF3425 PF11905.8 EXF86209.1 - 4.6e-20 71.9 1.2 1.5e-19 70.2 0.2 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF3425) DUF1653 PF07866.11 EXF86209.1 - 0.045 14.1 1.7 12 6.3 0.1 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1653) CPP1-like PF11833.8 EXF86209.1 - 0.24 11.1 1.5 0.4 10.3 1.5 1.2 1 0 0 1 1 1 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like bZIP_1 PF00170.21 EXF86209.1 - 3.7 7.7 10.6 7.5 6.7 10.6 1.4 1 0 0 1 1 1 0 bZIP transcription factor Zn_clus PF00172.18 EXF86210.1 - 1.2e-06 28.5 8.9 2.3e-06 27.6 8.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EXF86210.1 - 4.8e-06 25.6 0.2 8e-06 24.9 0.2 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain MSP1b PF03429.13 EXF86210.1 - 0.015 13.4 0.1 0.022 12.9 0.1 1.1 1 0 0 1 1 1 0 Major surface protein 1B Lipase_GDSL_2 PF13472.6 EXF86211.1 - 0.013 15.9 0.0 0.022 15.1 0.0 1.4 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family RRM_1 PF00076.22 EXF86212.1 - 6e-16 58.0 0.0 1.8e-09 37.3 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Serpentine_r_xa PF03383.15 EXF86213.1 - 1.4 8.9 10.7 0.25 11.3 6.1 2.1 1 1 1 2 2 2 0 Caenorhabditis serpentine receptor-like protein, class xa Abhydrolase_6 PF12697.7 EXF86214.1 - 2.4e-11 44.7 0.2 1.9e-10 41.7 0.2 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EXF86214.1 - 3.3e-05 23.3 0.0 0.016 14.5 0.0 2.3 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EXF86214.1 - 0.00033 20.4 0.0 0.0014 18.3 0.0 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EXF86214.1 - 0.0006 19.4 0.1 6.3 6.2 0.0 3.7 3 1 0 4 4 4 2 Prolyl oligopeptidase family Peptidase_M1_N PF17900.1 EXF86214.1 - 0.0031 17.7 0.0 0.0049 17.1 0.0 1.2 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain FSH1 PF03959.13 EXF86214.1 - 0.035 13.8 0.0 0.094 12.4 0.0 1.6 1 1 0 1 1 1 0 Serine hydrolase (FSH1) TPP_enzyme_N PF02776.18 EXF86214.1 - 0.11 12.1 0.0 0.22 11.1 0.0 1.4 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain AATase PF07247.12 EXF86215.1 - 1.8e-09 36.7 0.0 1.1e-08 34.2 0.0 2.1 3 0 0 3 3 3 1 Alcohol acetyltransferase WW_like PF17890.1 EXF86215.1 - 0.07 13.2 0.0 0.23 11.5 0.0 1.8 1 0 0 1 1 1 0 Peptidoglycan hydrolase LytB WW-like domain Methyltransf_2 PF00891.18 EXF86216.1 - 9.7e-21 74.0 0.0 1.8e-20 73.1 0.0 1.4 1 0 0 1 1 1 1 O-methyltransferase domain Pribosyltran PF00156.27 EXF86217.1 - 4.2e-07 29.6 0.1 1.1e-06 28.2 0.1 1.7 1 1 0 1 1 1 1 Phosphoribosyl transferase domain HU-CCDC81_bac_2 PF18175.1 EXF86217.1 - 0.13 12.1 0.1 0.37 10.7 0.0 1.7 2 0 0 2 2 2 0 CCDC81-like prokaryotic HU domain 2 Oxidored-like PF09791.9 EXF86219.1 - 1.2e-24 85.7 3.3 1.2e-24 85.7 3.3 2.2 2 0 0 2 2 2 1 Oxidoreductase-like protein, N-terminal Wtap PF17098.5 EXF86219.1 - 0.011 15.6 0.0 0.019 14.9 0.0 1.3 1 0 0 1 1 1 0 WTAP/Mum2p family Na_trans_assoc PF06512.13 EXF86220.1 - 0.036 14.4 0.5 0.16 12.2 0.1 2.1 2 0 0 2 2 2 0 Sodium ion transport-associated MCM_bind PF09739.9 EXF86220.1 - 0.074 11.5 0.4 0.14 10.6 0.4 1.4 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor MIF4G_like_2 PF09090.11 EXF86220.1 - 3.8 6.9 4.5 0.48 9.9 0.1 1.6 2 0 0 2 2 2 0 MIF4G like DUF4407 PF14362.6 EXF86220.1 - 5.2 6.3 10.8 2 7.7 2.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Tyrosinase PF00264.20 EXF86224.1 - 8.8e-23 81.7 2.7 1.6e-22 80.9 2.7 1.4 1 0 0 1 1 1 1 Common central domain of tyrosinase P-mevalo_kinase PF04275.14 EXF86224.1 - 4.8e-19 68.4 0.0 1e-18 67.3 0.0 1.6 1 0 0 1 1 1 1 Phosphomevalonate kinase FAD_binding_4 PF01565.23 EXF86224.1 - 5.3e-17 61.9 1.5 2.9e-16 59.5 1.8 2.0 2 0 0 2 2 2 1 FAD binding domain Pribosyltran PF00156.27 EXF86224.1 - 1.3e-07 31.3 0.0 3.1e-07 30.0 0.0 1.7 1 0 0 1 1 1 1 Phosphoribosyl transferase domain Gly_transf_sug PF04488.15 EXF86226.1 - 1.1e-07 32.4 0.0 2.5e-07 31.2 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Gypsy PF07253.11 EXF86227.1 - 0.03 12.9 0.2 0.046 12.3 0.2 1.2 1 0 0 1 1 1 0 Gypsy protein RF-1 PF00472.20 EXF86227.1 - 0.066 13.1 1.6 0.081 12.9 0.2 1.8 2 0 0 2 2 2 0 RF-1 domain Pkinase PF00069.25 EXF86228.1 - 0.00017 21.0 0.0 0.00039 19.9 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF86228.1 - 0.037 13.3 0.0 0.066 12.5 0.0 1.4 1 1 0 1 1 1 0 Protein tyrosine kinase OTT_1508_deam PF14441.6 EXF86229.1 - 9.8e-17 60.7 0.2 1.8e-16 59.9 0.2 1.4 1 0 0 1 1 1 1 OTT_1508-like deaminase NB-ARC PF00931.22 EXF86232.1 - 1.6e-08 34.0 0.0 3.7e-08 32.9 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain DUF676 PF05057.14 EXF86232.1 - 2.1e-05 24.2 0.1 5.7e-05 22.7 0.0 1.7 2 0 0 2 2 2 1 Putative serine esterase (DUF676) AAA_22 PF13401.6 EXF86232.1 - 6.8e-05 23.2 0.0 0.00017 21.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain Abhydrolase_6 PF12697.7 EXF86232.1 - 8.9e-05 23.2 0.3 0.00016 22.4 0.3 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family PGAP1 PF07819.13 EXF86232.1 - 0.002 17.9 0.0 0.0039 17.0 0.0 1.6 1 0 0 1 1 1 1 PGAP1-like protein IstB_IS21 PF01695.17 EXF86232.1 - 0.0079 16.0 0.0 0.019 14.7 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_16 PF13191.6 EXF86232.1 - 0.0095 16.3 0.9 0.092 13.1 0.9 2.6 1 1 0 1 1 1 1 AAA ATPase domain SRP54 PF00448.22 EXF86232.1 - 0.049 13.3 0.0 0.13 11.8 0.0 1.7 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain TPR_12 PF13424.6 EXF86232.1 - 0.093 13.0 0.0 0.25 11.7 0.0 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat PNP_phzG_C PF10590.9 EXF86232.1 - 0.11 12.6 0.1 0.33 11.1 0.1 1.8 1 0 0 1 1 1 0 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region NACHT PF05729.12 EXF86232.1 - 0.13 12.2 0.0 0.3 11.0 0.0 1.7 1 0 0 1 1 1 0 NACHT domain AAA_7 PF12775.7 EXF86232.1 - 0.19 11.2 0.0 0.43 10.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region DNA_pol_A_exo1 PF01612.20 EXF86234.1 - 1.8e-13 50.6 0.0 2.8e-13 49.9 0.0 1.3 1 0 0 1 1 1 1 3'-5' exonuclease HET PF06985.11 EXF86235.1 - 1.9e-32 112.6 2.7 5.3e-32 111.2 2.7 1.8 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) NdhO PF11910.8 EXF86235.1 - 0.074 13.2 2.2 9 6.5 0.2 3.2 2 0 0 2 2 2 0 Cyanobacterial and plant NDH-1 subunit O DUF2018 PF09442.10 EXF86235.1 - 0.15 13.1 17.2 3.4 8.7 1.2 5.3 1 1 3 5 5 5 0 Domain of unknown function (DUF2018) Drf_DAD PF06345.11 EXF86235.1 - 0.2 11.7 0.3 1.1 9.5 0.1 2.4 2 0 0 2 2 2 0 DRF Autoregulatory Domain CPL PF08144.11 EXF86235.1 - 0.91 9.9 9.7 22 5.4 0.4 4.5 1 1 4 6 6 6 0 CPL (NUC119) domain Auxin_inducible PF02519.14 EXF86235.1 - 2.6 8.2 4.4 1e+02 3.1 0.2 3.9 2 2 1 3 3 3 0 Auxin responsive protein DUF1476 PF07345.11 EXF86235.1 - 8.9 6.8 8.2 2.7 8.4 1.1 2.9 1 1 3 4 4 4 0 ATPase inhibitor subunit zeta Dynamin_N PF00350.23 EXF86236.1 - 5.3e-34 117.7 0.1 9.5e-34 116.9 0.1 1.4 1 0 0 1 1 1 1 Dynamin family Dynamin_M PF01031.20 EXF86236.1 - 7e-23 81.2 0.0 2.4e-20 73.0 0.0 2.4 2 0 0 2 2 2 2 Dynamin central region MMR_HSR1 PF01926.23 EXF86236.1 - 3.3e-05 23.9 0.1 0.0016 18.5 0.1 2.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EXF86236.1 - 0.023 14.2 0.0 5.9 6.4 0.0 2.4 2 0 0 2 2 2 0 Ferrous iron transport protein B Roc PF08477.13 EXF86236.1 - 0.072 13.3 0.0 0.34 11.1 0.0 2.2 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase ABC_tran PF00005.27 EXF86236.1 - 0.12 12.9 0.0 0.28 11.7 0.0 1.7 1 0 0 1 1 1 0 ABC transporter GED PF02212.18 EXF86236.1 - 0.26 11.5 1.9 2.2 8.5 1.9 2.6 1 1 0 1 1 1 0 Dynamin GTPase effector domain RdRP PF05183.12 EXF86237.1 - 6.4e-128 427.9 0.0 8.3e-128 427.6 0.0 1.1 1 0 0 1 1 1 1 RNA dependent RNA polymerase Piwi PF02171.17 EXF86238.1 - 1.4e-51 175.6 0.0 3.5e-50 171.0 0.0 2.2 1 1 0 1 1 1 1 Piwi domain ArgoL2 PF16488.5 EXF86238.1 - 5.1e-09 36.3 0.0 9.8e-09 35.4 0.0 1.5 1 0 0 1 1 1 1 Argonaute linker 2 domain ArgoL1 PF08699.10 EXF86238.1 - 0.0019 17.8 0.0 0.0051 16.5 0.0 1.8 1 0 0 1 1 1 1 Argonaute linker 1 domain Pkinase PF00069.25 EXF86240.1 - 1.3e-40 139.4 0.0 3.5e-40 138.1 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF86240.1 - 8.4e-25 87.5 0.0 1.1e-24 87.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EXF86240.1 - 0.0017 17.2 0.0 0.0027 16.6 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EXF86240.1 - 0.013 14.9 0.0 0.18 11.1 0.0 2.2 2 0 0 2 2 2 0 Kinase-like HU-HIG PF18291.1 EXF86240.1 - 0.06 13.4 0.0 0.2 11.7 0.0 1.8 1 1 1 2 2 2 0 HU domain fused to wHTH, Ig, or Glycine-rich motif FHA PF00498.26 EXF86240.1 - 0.12 12.7 0.0 0.24 11.7 0.0 1.4 1 0 0 1 1 1 0 FHA domain PNP_UDP_1 PF01048.20 EXF86241.1 - 1.8e-11 43.8 0.0 8e-11 41.6 0.0 2.2 1 1 0 1 1 1 1 Phosphorylase superfamily NACHT PF05729.12 EXF86241.1 - 1e-09 38.5 0.1 1.9e-09 37.6 0.1 1.5 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 EXF86241.1 - 1.4e-06 28.6 0.1 1.3e-05 25.5 0.0 2.5 2 1 1 3 3 3 1 AAA domain AAA_16 PF13191.6 EXF86241.1 - 1.5e-05 25.4 3.0 1.8e-05 25.2 0.1 2.5 3 0 0 3 3 3 1 AAA ATPase domain NB-ARC PF00931.22 EXF86241.1 - 7.1e-05 22.1 0.0 0.00017 20.9 0.0 1.6 1 0 0 1 1 1 1 NB-ARC domain ATPase_2 PF01637.18 EXF86241.1 - 0.00067 19.6 0.0 0.0012 18.8 0.0 1.3 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea RNA_helicase PF00910.22 EXF86241.1 - 0.047 14.1 0.0 0.15 12.4 0.0 1.9 2 0 0 2 2 2 0 RNA helicase AAA_14 PF13173.6 EXF86241.1 - 0.052 13.6 0.0 0.35 10.9 0.0 2.3 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EXF86241.1 - 0.058 12.9 0.0 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region zf_C2H2_13 PF18508.1 EXF86241.1 - 0.13 11.9 0.0 0.27 10.8 0.0 1.5 1 0 0 1 1 1 0 Zinc finger domain ResIII PF04851.15 EXF86241.1 - 0.14 12.1 0.0 0.26 11.2 0.0 1.4 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Parvo_NS1 PF01057.17 EXF86241.1 - 0.16 11.1 0.0 0.27 10.3 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 OTT_1508_deam PF14441.6 EXF86247.1 - 3.1e-21 75.1 0.9 6.2e-21 74.2 0.9 1.5 1 0 0 1 1 1 1 OTT_1508-like deaminase Methyltransf_23 PF13489.6 EXF86248.1 - 5.5e-06 26.3 0.0 9.3e-06 25.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 EXF86248.1 - 0.024 14.4 0.0 0.04 13.7 0.0 1.4 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Arg_repressor PF01316.21 EXF86248.1 - 0.1 12.3 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 Arginine repressor, DNA binding domain DUF445 PF04286.12 EXF86250.1 - 0.00087 19.2 2.8 0.0013 18.6 2.8 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF445) NPV_P10 PF05531.12 EXF86250.1 - 0.013 15.9 1.2 0.09 13.3 1.5 2.4 2 1 0 2 2 1 0 Nucleopolyhedrovirus P10 protein Tropomyosin_1 PF12718.7 EXF86250.1 - 0.029 14.5 11.2 0.048 13.8 11.2 1.3 1 0 0 1 1 1 0 Tropomyosin like RPW8 PF05659.11 EXF86250.1 - 0.05 13.3 1.2 0.1 12.3 1.2 1.5 1 0 0 1 1 1 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 bZIP_1 PF00170.21 EXF86250.1 - 0.14 12.3 5.7 0.1 12.7 3.1 1.9 1 1 0 2 2 2 0 bZIP transcription factor DUF724 PF05266.14 EXF86250.1 - 0.18 11.6 5.8 0.31 10.8 5.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF724) ATG16 PF08614.11 EXF86250.1 - 0.2 11.8 11.6 0.34 11.1 11.6 1.3 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) GIT_CC PF16559.5 EXF86250.1 - 0.32 10.9 8.2 1 9.3 8.2 1.8 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor TPD52 PF04201.15 EXF86250.1 - 0.32 10.6 2.8 0.56 9.8 2.8 1.3 1 0 0 1 1 1 0 Tumour protein D52 family SOGA PF11365.8 EXF86250.1 - 0.79 10.9 10.4 15 6.8 8.8 3.0 1 1 2 3 3 3 0 Protein SOGA DUF1664 PF07889.12 EXF86250.1 - 2.9 8.0 7.1 6.5 6.8 7.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) DivIC PF04977.15 EXF86250.1 - 4.6 7.1 10.0 25 4.7 10.0 2.1 1 1 0 1 1 1 0 Septum formation initiator DUF5320 PF17253.2 EXF86250.1 - 5.5 8.1 5.7 7.9 7.6 2.8 2.2 1 1 1 2 2 2 0 Family of unknown function (DUF5320) ZapB PF06005.12 EXF86250.1 - 7.4 7.1 15.9 4.5 7.8 11.8 2.3 1 1 1 2 2 2 0 Cell division protein ZapB AA_permease PF00324.21 EXF86251.1 - 0.18 10.4 0.1 0.23 10.0 0.1 1.1 1 0 0 1 1 1 0 Amino acid permease Pkinase_fungal PF17667.1 EXF86254.1 - 2.6e-133 444.7 0.0 3.5e-133 444.3 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Pkinase PF00069.25 EXF86254.1 - 0.0016 17.9 0.0 0.0027 17.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 EXF86254.1 - 0.0059 16.6 0.1 0.17 11.8 0.0 2.8 2 1 1 3 3 3 1 Phosphotransferase enzyme family MauJ PF17419.2 EXF86254.1 - 0.032 13.7 0.0 0.054 13.0 0.0 1.3 1 0 0 1 1 1 0 Methylamine utilization protein MauJ TFIIF_beta PF02270.15 EXF86255.1 - 0.097 12.8 0.1 0.18 11.9 0.1 1.4 1 0 0 1 1 1 0 TFIIF, beta subunit HTH domain dsrm PF00035.26 EXF86256.1 - 0.0097 16.6 0.0 0.015 16.0 0.0 1.3 1 0 0 1 1 1 1 Double-stranded RNA binding motif DND1_DSRM PF14709.7 EXF86256.1 - 0.013 15.8 0.1 0.056 13.7 0.1 1.9 1 1 0 1 1 1 0 double strand RNA binding domain from DEAD END PROTEIN 1 DUF2850 PF11012.8 EXF86256.1 - 0.14 12.5 0.0 0.21 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2850) BCS1_N PF08740.11 EXF86258.1 - 4.6e-21 75.6 0.0 9.1e-21 74.7 0.0 1.5 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 EXF86258.1 - 1.2e-15 58.1 0.0 2.6e-15 57.0 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EXF86258.1 - 0.00059 20.2 0.0 0.0018 18.7 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.6 EXF86258.1 - 0.0021 18.2 0.0 0.0084 16.3 0.0 2.1 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.12 EXF86258.1 - 0.0034 17.1 0.0 0.0068 16.2 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_11 PF13086.6 EXF86258.1 - 0.013 15.4 0.0 0.021 14.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EXF86258.1 - 0.019 15.2 0.0 0.11 12.7 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 EXF86258.1 - 0.022 15.0 0.1 3.1 8.0 0.0 2.5 1 1 1 2 2 2 0 AAA domain AAA_18 PF13238.6 EXF86258.1 - 0.023 15.3 0.0 0.052 14.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EXF86258.1 - 0.08 13.3 0.0 0.22 11.9 0.0 1.8 1 0 0 1 1 1 0 RNA helicase AAA_7 PF12775.7 EXF86258.1 - 0.099 12.1 0.0 0.39 10.2 0.0 1.9 1 1 1 2 2 2 0 P-loop containing dynein motor region AAA_25 PF13481.6 EXF86258.1 - 0.13 11.8 0.0 0.38 10.3 0.0 1.7 2 0 0 2 2 2 0 AAA domain FAD_binding_4 PF01565.23 EXF86259.1 - 2.2e-27 95.5 0.3 4.3e-27 94.6 0.3 1.5 1 0 0 1 1 1 1 FAD binding domain PEP_hydrolase PF09370.10 EXF86260.1 - 0.08 12.2 0.0 0.13 11.4 0.0 1.3 1 0 0 1 1 1 0 Phosphoenolpyruvate hydrolase-like DUF3435 PF11917.8 EXF86264.1 - 1.1e-62 212.4 1.5 1.3e-62 212.2 0.2 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF3435) FOXP-CC PF16159.5 EXF86264.1 - 0.078 13.6 0.2 0.28 11.8 0.2 1.9 1 0 0 1 1 1 0 FOXP coiled-coil domain RRP36 PF06102.12 EXF86264.1 - 0.5 10.3 7.3 0.066 13.2 2.9 1.7 2 0 0 2 2 2 0 rRNA biogenesis protein RRP36 Kdo PF06293.14 EXF86265.1 - 8.9e-05 21.9 0.0 0.00018 20.9 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Radial_spoke_3 PF06098.11 EXF86265.1 - 0.00084 18.7 6.6 0.0017 17.7 6.6 1.5 1 0 0 1 1 1 1 Radial spoke protein 3 APH PF01636.23 EXF86265.1 - 0.0099 15.8 0.1 0.0099 15.8 0.1 3.1 2 1 1 3 3 3 1 Phosphotransferase enzyme family HSDR_N_2 PF13588.6 EXF86265.1 - 0.011 15.7 0.0 0.8 9.7 0.0 2.5 1 1 0 1 1 1 0 Type I restriction enzyme R protein N terminus (HSDR_N) Pkinase_fungal PF17667.1 EXF86265.1 - 0.095 11.5 0.8 0.11 11.2 0.0 1.6 2 0 0 2 2 2 0 Fungal protein kinase Casc1_N PF15927.5 EXF86265.1 - 6.5 6.4 16.4 12 5.5 16.4 1.4 1 0 0 1 1 1 0 Cancer susceptibility candidate 1 N-terminus RCR PF12273.8 EXF86269.1 - 4.7e-10 40.2 10.4 1.5e-09 38.6 10.3 1.8 1 1 0 1 1 1 1 Chitin synthesis regulation, resistance to Congo red CPSF73-100_C PF11718.8 EXF86270.1 - 0.18 11.3 0.5 0.22 11.1 0.5 1.2 1 0 0 1 1 1 0 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term tRNA-synt_2c PF01411.19 EXF86271.1 - 2.8e-210 699.5 0.0 4.6e-210 698.8 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class II (A) tRNA_SAD PF07973.14 EXF86271.1 - 2.8e-17 62.5 0.3 7.9e-17 61.1 0.3 1.9 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain DHHA1 PF02272.19 EXF86271.1 - 1e-10 42.2 3.8 1e-10 42.2 3.8 2.1 2 0 0 2 2 2 1 DHHA1 domain Mitoc_L55 PF09776.9 EXF86271.1 - 0.056 13.2 1.3 4.4 7.1 0.1 3.2 3 0 0 3 3 3 0 Mitochondrial ribosomal protein L55 ChaB PF06150.12 EXF86271.1 - 0.19 12.3 1.1 1.2 9.8 1.1 2.4 1 0 0 1 1 1 0 ChaB Methyltransf_28 PF02636.17 EXF86272.1 - 1.4e-43 149.5 0.0 2.1e-43 148.9 0.0 1.2 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase PRMT5 PF05185.16 EXF86272.1 - 0.00095 19.1 0.0 0.0026 17.6 0.0 1.7 2 0 0 2 2 2 1 PRMT5 arginine-N-methyltransferase FAD_SOX PF18371.1 EXF86272.1 - 0.085 13.2 0.0 0.28 11.6 0.0 1.8 2 0 0 2 2 2 0 Flavin adenine dinucleotide (FAD)-dependent sulfhydryl oxidase PHP_C PF13263.6 EXF86272.1 - 0.1 12.4 0.0 0.38 10.6 0.0 1.8 2 0 0 2 2 2 0 PHP-associated PALP PF00291.25 EXF86273.1 - 8.3e-64 215.8 5.2 1.1e-63 215.4 5.2 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme TFIIS_M PF07500.14 EXF86274.1 - 1.9e-29 102.4 2.2 1.9e-29 102.4 2.2 2.0 2 1 0 2 2 2 1 Transcription factor S-II (TFIIS), central domain TFIIS_C PF01096.18 EXF86274.1 - 1.6e-18 66.3 6.0 2.6e-18 65.6 6.0 1.4 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) Med26 PF08711.11 EXF86274.1 - 7.3e-12 45.1 0.4 2.2e-11 43.6 0.4 1.8 1 0 0 1 1 1 1 TFIIS helical bundle-like domain CPSF100_C PF13299.6 EXF86274.1 - 0.065 13.4 0.6 0.065 13.4 0.6 2.5 2 1 1 3 3 3 0 Cleavage and polyadenylation factor 2 C-terminal DUF2868 PF11067.8 EXF86274.1 - 0.17 11.3 5.6 0.15 11.6 2.9 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2868) Ku_C PF03730.14 EXF86274.1 - 1.9 9.3 6.9 0.5 11.1 0.9 2.7 2 1 0 2 2 2 0 Ku70/Ku80 C-terminal arm DUF848 PF05852.11 EXF86275.1 - 0.019 15.1 0.5 0.17 12.0 0.1 2.4 2 0 0 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) SPC12 PF06645.13 EXF86275.1 - 0.15 12.1 0.8 0.3 11.2 0.8 1.4 1 0 0 1 1 1 0 Microsomal signal peptidase 12 kDa subunit (SPC12) zf-RING_2 PF13639.6 EXF86276.1 - 4.5e-12 46.1 6.5 8e-12 45.3 6.5 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 EXF86276.1 - 2.9e-08 33.3 5.1 2.9e-08 33.3 5.1 1.8 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 EXF86276.1 - 1.3e-07 31.4 5.2 2.5e-07 30.4 5.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EXF86276.1 - 1.2e-06 28.2 5.3 2.3e-06 27.4 5.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EXF86276.1 - 6.2e-06 26.1 4.2 1.1e-05 25.3 4.2 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.7 EXF86276.1 - 2.6e-05 24.4 3.0 6.4e-05 23.2 3.0 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 EXF86276.1 - 5.3e-05 23.0 3.9 9.4e-05 22.2 3.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EXF86276.1 - 6e-05 23.0 1.9 6e-05 23.0 1.9 2.5 2 0 0 2 2 2 1 RING-type zinc-finger Prok-RING_4 PF14447.6 EXF86276.1 - 6.2e-05 22.8 5.8 0.00012 21.8 5.8 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 EXF86276.1 - 0.0085 16.1 1.0 0.02 15.0 1.0 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.6 EXF86276.1 - 0.05 13.4 3.4 0.089 12.6 3.4 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Zn_ribbon_17 PF17120.5 EXF86276.1 - 0.059 13.0 2.3 0.12 12.1 2.3 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type TackOD1 PF18551.1 EXF86276.1 - 0.07 12.8 1.0 0.12 12.1 1.0 1.3 1 0 0 1 1 1 0 Thaumarchaeal output domain 1 MRC1 PF09444.10 EXF86276.1 - 0.13 12.8 0.5 0.74 10.3 0.1 2.1 2 0 0 2 2 2 0 MRC1-like domain Vps39_2 PF10367.9 EXF86276.1 - 0.85 10.1 3.7 0.31 11.5 0.6 1.9 2 0 0 2 2 1 0 Vacuolar sorting protein 39 domain 2 RINGv PF12906.7 EXF86276.1 - 0.87 9.8 2.6 1.6 8.9 2.6 1.5 1 0 0 1 1 1 0 RING-variant domain zf-C3HC4_4 PF15227.6 EXF86276.1 - 0.97 9.7 6.0 2.2 8.5 6.0 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING PHD PF00628.29 EXF86276.1 - 1.4 8.9 3.7 2.9 7.9 3.7 1.6 1 0 0 1 1 1 0 PHD-finger DUF913 PF06025.12 EXF86276.1 - 8.9 5.2 8.6 1.5 7.7 0.2 2.6 3 0 0 3 3 3 0 Domain of Unknown Function (DUF913) Glyco_hydro_45 PF02015.16 EXF86277.1 - 2.3e-26 93.0 2.2 2.9e-26 92.7 2.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 45 Rtt102p PF09510.10 EXF86277.1 - 0.13 12.5 0.0 0.15 12.2 0.0 1.1 1 0 0 1 1 1 0 Rtt102p-like transcription regulator protein Inositol_P PF00459.25 EXF86278.1 - 2.6e-68 230.5 0.0 3.1e-68 230.2 0.0 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family ArfA PF03889.13 EXF86278.1 - 0.17 11.4 0.1 0.32 10.5 0.1 1.4 1 0 0 1 1 1 0 Alternative ribosome-rescue factor A Isochorismatase PF00857.20 EXF86280.1 - 2.7e-33 115.6 0.0 8.4e-32 110.7 0.0 2.0 1 1 0 1 1 1 1 Isochorismatase family Lactamase_B_2 PF12706.7 EXF86281.1 - 8.8e-16 58.0 0.1 1.4e-15 57.4 0.1 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 EXF86281.1 - 8.1e-12 45.3 0.0 1.1e-11 44.9 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain NACHT_N PF17100.5 EXF86282.1 - 4.7e-18 65.8 0.0 6.3e-18 65.4 0.0 1.1 1 0 0 1 1 1 1 N-terminal domain of NWD NACHT-NTPase RasGEF PF00617.19 EXF86284.1 - 1.2e-59 201.5 0.0 2.1e-59 200.7 0.0 1.4 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 EXF86284.1 - 2.9e-28 98.2 0.7 6e-28 97.2 0.7 1.6 1 0 0 1 1 1 1 RasGEF N-terminal motif SH3_1 PF00018.28 EXF86284.1 - 1.8e-15 56.3 0.1 3.7e-15 55.3 0.1 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EXF86284.1 - 4e-14 52.2 0.2 8.6e-14 51.1 0.2 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EXF86284.1 - 2.7e-13 49.4 0.1 5.8e-13 48.3 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain WW PF00397.26 EXF86284.1 - 0.074 13.2 0.0 0.17 12.0 0.0 1.6 1 0 0 1 1 1 0 WW domain Fungal_trans PF04082.18 EXF86286.1 - 3.5e-16 59.0 2.1 5.4e-16 58.4 2.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-H2C2_2 PF13465.6 EXF86286.1 - 1.1e-07 31.9 13.4 1.1e-05 25.6 5.8 3.0 2 0 0 2 2 2 2 Zinc-finger double domain zf-C2H2 PF00096.26 EXF86286.1 - 0.00069 19.9 14.6 0.039 14.4 5.3 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_3rep PF18868.1 EXF86286.1 - 0.033 14.9 0.8 3.2 8.4 0.1 2.8 2 1 1 3 3 3 0 Zinc finger C2H2-type, 3 repeats ALG11_N PF15924.5 EXF86286.1 - 0.15 12.1 0.0 0.32 11.0 0.0 1.5 1 0 0 1 1 1 0 ALG11 mannosyltransferase N-terminus Zn-ribbon_8 PF09723.10 EXF86286.1 - 1.3 9.2 4.1 4.1 7.6 4.1 1.9 1 0 0 1 1 1 0 Zinc ribbon domain zf-C2H2_4 PF13894.6 EXF86286.1 - 9.6 7.3 25.2 0.27 12.2 4.1 3.5 4 0 0 4 4 4 0 C2H2-type zinc finger Glyco_hydro_16 PF00722.21 EXF86287.1 - 1.5e-16 60.4 0.0 2.4e-16 59.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 Glyco_hydro_64 PF16483.5 EXF86288.1 - 8.3e-140 466.2 0.2 1.1e-139 465.9 0.2 1.1 1 0 0 1 1 1 1 Beta-1,3-glucanase Fungal_trans_2 PF11951.8 EXF86289.1 - 1.3e-12 47.2 0.1 1.3e-09 37.4 0.0 2.2 2 0 0 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF86289.1 - 2.4e-07 30.8 11.7 4.4e-07 29.9 11.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF4619 PF15398.6 EXF86289.1 - 0.091 12.3 0.1 0.14 11.6 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4619) Pro_isomerase PF00160.21 EXF86290.1 - 2.6e-49 167.5 0.0 4.7e-49 166.7 0.0 1.5 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD U-box PF04564.15 EXF86290.1 - 0.00019 21.5 0.0 0.00071 19.7 0.0 1.9 1 0 0 1 1 1 1 U-box domain zf-NOSIP PF15906.5 EXF86290.1 - 0.0012 18.9 0.0 0.0028 17.7 0.0 1.6 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein Lung_7-TM_R PF06814.13 EXF86291.1 - 1.1e-70 238.3 16.6 1.4e-70 237.9 16.6 1.1 1 0 0 1 1 1 1 Lung seven transmembrane receptor SurA_N_3 PF13624.6 EXF86291.1 - 0.56 10.0 2.0 9.4 6.0 0.3 2.7 2 0 0 2 2 2 0 SurA N-terminal domain DUF1980 PF09323.10 EXF86291.1 - 0.91 9.4 4.4 0.39 10.6 0.3 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF1980) DUF4492 PF14899.6 EXF86291.1 - 1.4 8.9 5.6 0.65 9.9 1.4 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4492) Methyltransf_28 PF02636.17 EXF86292.1 - 7.6e-81 271.6 0.0 9.4e-81 271.3 0.0 1.1 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Pkinase PF00069.25 EXF86293.1 - 8.8e-62 208.8 0.0 1.2e-61 208.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF86293.1 - 6.2e-29 101.1 0.0 1e-28 100.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EXF86293.1 - 0.00049 19.5 0.0 0.00089 18.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EXF86293.1 - 0.012 15.5 1.4 0.025 14.5 0.0 2.1 2 0 0 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.14 EXF86293.1 - 0.036 13.4 0.0 0.06 12.7 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family LpxI_C PF06230.11 EXF86293.1 - 0.15 12.0 0.0 0.27 11.1 0.0 1.4 1 0 0 1 1 1 0 LpxI C-terminal domain Haspin_kinase PF12330.8 EXF86293.1 - 0.15 11.0 0.0 0.21 10.5 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain SOG2 PF10428.9 EXF86294.1 - 0.065 12.4 2.4 0.081 12.1 2.4 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein DmpG_comm PF07836.11 EXF86294.1 - 0.12 12.0 0.1 0.23 11.0 0.1 1.4 1 0 0 1 1 1 0 DmpG-like communication domain MGC-24 PF05283.11 EXF86294.1 - 9.2 6.7 13.5 0.73 10.3 7.8 2.0 2 0 0 2 2 2 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin Rdx PF10262.9 EXF86295.1 - 1.5e-21 76.4 0.0 2.7e-21 75.5 0.0 1.4 1 0 0 1 1 1 1 Rdx family S100PBPR PF15427.6 EXF86295.1 - 0.16 11.2 3.2 0.21 10.8 3.2 1.2 1 0 0 1 1 1 0 S100P-binding protein Macoilin PF09726.9 EXF86295.1 - 1.5 7.3 3.4 1.9 6.9 3.4 1.1 1 0 0 1 1 1 0 Macoilin family Hamartin PF04388.12 EXF86295.1 - 8.5 4.9 10.6 11 4.6 10.6 1.0 1 0 0 1 1 1 0 Hamartin protein Metallophos PF00149.28 EXF86296.1 - 4.1e-40 138.5 0.1 5.3e-40 138.1 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EXF86296.1 - 3.3e-23 81.9 1.8 4.7e-23 81.4 1.0 1.7 2 0 0 2 2 2 1 Serine-threonine protein phosphatase N-terminal domain zf-HC5HC2H_2 PF13832.6 EXF86297.1 - 3e-33 114.3 7.7 3e-33 114.3 7.7 2.4 2 0 0 2 2 2 1 PHD-zinc-finger like domain EPL1 PF10513.9 EXF86297.1 - 5.1e-27 95.2 0.1 2.9e-26 92.7 0.0 2.4 2 0 0 2 2 2 1 Enhancer of polycomb-like zf-HC5HC2H PF13771.6 EXF86297.1 - 5.2e-26 90.7 7.6 5.2e-26 90.7 7.6 2.7 3 0 0 3 3 3 1 PHD-like zinc-binding domain PHD_2 PF13831.6 EXF86297.1 - 3.4e-14 52.1 1.9 3.4e-14 52.1 1.9 2.4 2 0 0 2 2 2 1 PHD-finger PHD PF00628.29 EXF86297.1 - 2e-09 37.2 23.5 1.3e-08 34.6 9.5 2.7 2 0 0 2 2 2 2 PHD-finger zf-PHD-like PF15446.6 EXF86297.1 - 2 8.0 12.9 0.017 14.7 1.6 2.4 2 0 0 2 2 2 0 PHD/FYVE-zinc-finger like domain Biotin_lipoyl PF00364.22 EXF86298.1 - 6.6e-19 67.5 0.9 1.3e-18 66.6 0.9 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 EXF86298.1 - 3.5e-06 27.3 0.1 3.5e-06 27.3 0.1 2.3 2 0 0 2 2 2 1 e3 binding domain Biotin_lipoyl_2 PF13533.6 EXF86298.1 - 0.0004 20.1 0.0 0.0036 17.1 0.0 2.3 2 0 0 2 2 2 1 Biotin-lipoyl like HlyD_3 PF13437.6 EXF86298.1 - 0.0056 17.4 0.1 0.37 11.5 0.0 2.7 1 1 1 2 2 2 1 HlyD family secretion protein DUF1631 PF07793.11 EXF86298.1 - 1.6 7.0 8.1 1.2 7.5 6.2 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1631) SCO1-SenC PF02630.14 EXF86300.1 - 0.15 12.0 0.0 0.23 11.4 0.0 1.4 2 0 0 2 2 2 0 SCO1/SenC LRR_4 PF12799.7 EXF86301.1 - 1.2e-12 47.9 2.6 0.00046 20.5 0.8 3.6 3 0 0 3 3 3 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EXF86301.1 - 1.4e-12 47.1 6.0 6.8e-08 32.2 3.1 3.2 1 1 1 3 3 3 3 Leucine rich repeat LRR_1 PF00560.33 EXF86301.1 - 6e-05 23.0 6.1 22 6.1 0.2 5.7 4 2 0 4 4 4 2 Leucine Rich Repeat LRR_9 PF14580.6 EXF86301.1 - 0.002 17.7 0.4 0.0072 15.8 0.3 1.8 1 1 1 2 2 2 1 Leucine-rich repeat LRR_6 PF13516.6 EXF86301.1 - 0.025 14.6 11.1 14 6.1 0.0 5.2 5 0 0 5 5 5 0 Leucine Rich repeat Fungal_trans PF04082.18 EXF86302.1 - 3.7e-21 75.3 0.0 6.2e-21 74.6 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF86302.1 - 1.4e-08 34.7 12.3 2.7e-08 33.8 12.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Glyco_hydro_88 PF07470.13 EXF86304.1 - 4.1e-35 121.5 0.2 4.7e-35 121.3 0.2 1.1 1 0 0 1 1 1 1 Glycosyl Hydrolase Family 88 p450 PF00067.22 EXF86306.1 - 2.4e-57 194.7 0.0 4.4e-57 193.8 0.0 1.4 1 1 0 1 1 1 1 Cytochrome P450 ketoacyl-synt PF00109.26 EXF86307.1 - 1e-64 218.5 0.1 2e-64 217.6 0.1 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain SAT PF16073.5 EXF86307.1 - 4.9e-45 154.1 0.0 1.6e-44 152.4 0.0 1.9 2 0 0 2 2 2 1 Starter unit:ACP transacylase in aflatoxin biosynthesis Acyl_transf_1 PF00698.21 EXF86307.1 - 1.1e-43 150.0 0.0 2.2e-43 149.0 0.0 1.5 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EXF86307.1 - 5.3e-36 123.2 0.6 1.4e-35 121.9 0.0 2.0 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain PP-binding PF00550.25 EXF86307.1 - 5.7e-13 49.0 0.2 1.9e-12 47.3 0.1 2.0 2 0 0 2 2 2 1 Phosphopantetheine attachment site PS-DH PF14765.6 EXF86307.1 - 6.4e-13 48.6 0.0 1.2e-12 47.7 0.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase Thioesterase PF00975.20 EXF86307.1 - 4.4e-11 43.4 0.2 2.6e-10 40.8 0.0 2.3 2 0 0 2 2 2 1 Thioesterase domain KAsynt_C_assoc PF16197.5 EXF86307.1 - 1.8e-06 28.4 0.1 4.3e-06 27.1 0.1 1.6 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension adh_short PF00106.25 EXF86308.1 - 1.8e-21 76.5 0.2 8.9e-21 74.2 0.2 1.8 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF86308.1 - 2.1e-14 53.6 0.1 3e-13 49.9 0.1 1.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF86308.1 - 4.7e-05 23.4 0.0 7.2e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 KR domain THF_DHG_CYH_C PF02882.19 EXF86308.1 - 0.078 12.3 0.0 0.17 11.2 0.0 1.5 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain DUF1776 PF08643.10 EXF86308.1 - 0.1 11.9 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) p450 PF00067.22 EXF86309.1 - 6.5e-45 153.7 0.0 8.5e-45 153.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 PI_PP_I PF18363.1 EXF86309.1 - 0.11 12.7 1.5 15 5.9 0.1 2.4 2 0 0 2 2 2 0 Phosphoinositide phosphatase insertion domain MFS_1 PF07690.16 EXF86310.1 - 7.7e-22 77.7 22.6 7.7e-22 77.7 22.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF86310.1 - 2.8e-05 23.2 0.8 2.8e-05 23.2 0.8 3.3 2 1 0 3 3 3 2 Sugar (and other) transporter HTH_50 PF18024.1 EXF86310.1 - 0.074 12.7 0.0 0.24 11.0 0.0 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain MFS_1 PF07690.16 EXF86311.1 - 1.1e-37 129.8 52.8 1.1e-37 129.8 52.8 2.6 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EXF86311.1 - 4.2e-12 45.3 16.1 6.2e-12 44.7 16.1 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Methyltransf_23 PF13489.6 EXF86312.1 - 3.4e-09 36.7 0.0 5.3e-09 36.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF86312.1 - 3.5e-07 30.8 0.0 8.9e-07 29.5 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF86312.1 - 2.6e-06 28.1 0.0 7.6e-06 26.6 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF86312.1 - 4.1e-06 27.3 0.0 1.3e-05 25.7 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain SnoaL PF07366.12 EXF86313.1 - 5.6e-12 45.6 1.4 2.5e-11 43.5 0.8 2.0 2 0 0 2 2 2 1 SnoaL-like polyketide cyclase SnoaL_2 PF12680.7 EXF86313.1 - 4.2e-06 27.3 0.7 4.9e-05 23.9 0.6 2.2 2 0 0 2 2 2 1 SnoaL-like domain UPF0203 PF05254.12 EXF86313.1 - 0.016 15.4 0.3 0.82 10.0 0.0 2.6 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0203) adh_short PF00106.25 EXF86314.1 - 3.9e-23 81.9 0.1 9.7e-23 80.6 0.1 1.6 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF86314.1 - 7.7e-15 55.1 0.0 4e-14 52.7 0.0 1.8 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF86314.1 - 3.6e-05 23.8 0.0 5.2e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 KR domain DUF2292 PF10055.9 EXF86314.1 - 0.069 12.8 0.0 0.14 11.8 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized small protein (DUF2292) ketoacyl-synt PF00109.26 EXF86315.1 - 1.5e-71 241.0 0.0 4.8e-71 239.3 0.0 1.9 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.10 EXF86315.1 - 1.3e-62 210.9 0.0 2.4e-61 206.8 0.0 2.7 2 0 0 2 2 2 1 KR domain Acyl_transf_1 PF00698.21 EXF86315.1 - 7.3e-57 193.3 1.0 1.2e-56 192.5 1.0 1.3 1 0 0 1 1 1 1 Acyl transferase domain PS-DH PF14765.6 EXF86315.1 - 1.9e-41 142.3 0.0 3.3e-41 141.5 0.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase Ketoacyl-synt_C PF02801.22 EXF86315.1 - 1e-33 115.9 0.1 3e-33 114.3 0.1 1.9 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 EXF86315.1 - 5.1e-17 62.3 0.0 1.2e-16 61.2 0.0 1.6 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension ADH_zinc_N PF00107.26 EXF86315.1 - 9.9e-17 61.1 0.0 3.7e-16 59.3 0.0 2.0 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EXF86315.1 - 2.2e-16 61.1 0.0 7.8e-16 59.3 0.0 2.0 1 0 0 1 1 1 1 Zinc-binding dehydrogenase adh_short PF00106.25 EXF86315.1 - 1e-11 44.7 0.1 3.1e-10 39.9 0.0 3.0 3 0 0 3 3 3 1 short chain dehydrogenase PP-binding PF00550.25 EXF86315.1 - 1.6e-06 28.3 0.0 4.3e-06 27.0 0.0 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site adh_short_C2 PF13561.6 EXF86315.1 - 1.8e-06 27.7 0.0 5.6e-06 26.1 0.0 1.8 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase ADH_N PF08240.12 EXF86315.1 - 2e-06 27.6 0.2 4.3e-06 26.6 0.2 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Thiolase_N PF00108.23 EXF86315.1 - 1.2e-05 24.8 0.3 4.4e-05 23.0 0.1 1.9 2 0 0 2 2 2 1 Thiolase, N-terminal domain SAT PF16073.5 EXF86315.1 - 3e-05 23.9 0.0 0.08 12.7 0.1 2.7 2 0 0 2 2 2 2 Starter unit:ACP transacylase in aflatoxin biosynthesis DUF1759 PF03564.15 EXF86315.1 - 0.12 12.3 0.0 0.27 11.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1759) Glyco_hydro_1 PF00232.18 EXF86316.1 - 6.6e-73 245.7 0.1 1.8e-72 244.2 0.1 1.6 1 1 0 1 1 1 1 Glycosyl hydrolase family 1 adh_short PF00106.25 EXF86316.1 - 1.2e-35 122.8 0.8 1.8e-35 122.2 0.8 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF86316.1 - 1.6e-30 106.4 0.4 2.4e-30 105.8 0.4 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF86316.1 - 5.7e-06 26.4 0.0 1.7e-05 24.8 0.0 1.7 2 0 0 2 2 2 1 KR domain Epimerase PF01370.21 EXF86316.1 - 0.00067 19.2 0.1 0.001 18.6 0.1 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Methyltransf_25 PF13649.6 EXF86316.1 - 0.017 15.8 0.0 0.041 14.6 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain 3Beta_HSD PF01073.19 EXF86316.1 - 0.023 13.7 0.0 0.038 13.0 0.0 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Peptidase_S8 PF00082.22 EXF86317.1 - 3.2e-49 167.8 2.5 4.7e-49 167.3 2.5 1.2 1 0 0 1 1 1 1 Subtilase family fn3_5 PF06280.12 EXF86317.1 - 4.8e-19 69.1 0.1 9.5e-19 68.2 0.1 1.5 1 0 0 1 1 1 1 Fn3-like domain p450 PF00067.22 EXF86318.1 - 2e-56 191.7 0.0 3e-56 191.1 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 DUF4538 PF15061.6 EXF86318.1 - 0.18 11.6 2.6 0.36 10.6 2.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4538) Ubie_methyltran PF01209.18 EXF86319.1 - 3.2e-12 46.3 0.0 3.9e-12 46.0 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_11 PF08241.12 EXF86319.1 - 3.5e-12 46.8 0.0 6e-12 46.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF86319.1 - 4.1e-12 46.6 0.0 7.3e-12 45.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF86319.1 - 2.7e-07 30.5 0.0 3.5e-07 30.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF86319.1 - 4.1e-06 27.4 0.0 6.7e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EXF86319.1 - 0.00063 19.6 0.0 0.0008 19.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Gpr1_Fun34_YaaH PF01184.19 EXF86319.1 - 0.089 12.4 0.0 0.12 12.0 0.0 1.2 1 0 0 1 1 1 0 GPR1/FUN34/yaaH family Nucleoporin_N PF08801.11 EXF86320.1 - 1.8e-97 326.8 0.0 2.7e-97 326.2 0.0 1.3 1 0 0 1 1 1 1 Nup133 N terminal like Nucleoporin_C PF03177.14 EXF86320.1 - 1.3e-51 176.0 5.9 5.7e-51 174.0 1.4 2.0 1 1 0 2 2 2 2 Non-repetitive/WGA-negative nucleoporin C-terminal Phasin_2 PF09361.10 EXF86320.1 - 0.0013 19.0 0.4 0.0054 17.0 0.4 2.1 1 0 0 1 1 1 1 Phasin protein adh_short PF00106.25 EXF86321.1 - 3.2e-40 137.7 0.0 4.4e-40 137.2 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EXF86321.1 - 1.1e-25 90.6 0.0 1.6e-25 90.0 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EXF86321.1 - 1.5e-06 28.3 0.0 3.9e-06 26.9 0.0 1.6 1 1 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EXF86321.1 - 0.0024 17.1 0.0 0.0031 16.7 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.6 EXF86321.1 - 0.033 14.1 0.0 0.058 13.3 0.0 1.4 1 1 0 1 1 1 0 NAD(P)H-binding Erg28 PF03694.13 EXF86322.1 - 1.5e-44 150.9 0.7 1.8e-44 150.6 0.7 1.1 1 0 0 1 1 1 1 Erg28 like protein GalP_UDP_tr_C PF02744.17 EXF86323.1 - 3.1e-60 202.7 0.7 5.8e-60 201.8 0.3 1.6 2 0 0 2 2 2 1 Galactose-1-phosphate uridyl transferase, C-terminal domain GalP_UDP_transf PF01087.22 EXF86323.1 - 1e-50 172.7 1.6 1.5e-41 142.8 0.1 3.1 2 1 1 3 3 3 2 Galactose-1-phosphate uridyl transferase, N-terminal domain HIT PF01230.23 EXF86323.1 - 2.2e-07 31.5 0.2 3.8e-05 24.4 0.0 2.6 2 1 0 2 2 2 2 HIT domain ZZ PF00569.17 EXF86324.1 - 2.9e-10 39.8 7.2 5.5e-10 38.9 7.2 1.4 1 0 0 1 1 1 1 Zinc finger, ZZ type Myb_DNA-binding PF00249.31 EXF86324.1 - 4.6e-09 36.3 0.0 2.9e-08 33.8 0.0 2.2 2 0 0 2 2 2 1 Myb-like DNA-binding domain SWIRM PF04433.17 EXF86324.1 - 1.5e-07 31.7 0.0 4.2e-07 30.2 0.0 1.7 1 0 0 1 1 1 1 SWIRM domain CEBP_ZZ PF16366.5 EXF86324.1 - 1.7 8.9 5.7 4.3 7.6 5.7 1.7 1 0 0 1 1 1 0 Cytoplasmic polyadenylation element-binding protein ZZ domain ubiquitin PF00240.23 EXF86328.1 - 3.1e-21 74.9 0.0 5.1e-21 74.2 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EXF86328.1 - 3.2e-11 42.9 0.0 5.8e-11 42.1 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_4 PF18036.1 EXF86328.1 - 0.017 15.2 0.1 0.076 13.1 0.0 2.0 1 1 1 2 2 2 0 Ubiquitin-like domain TBK1_ULD PF18396.1 EXF86328.1 - 0.058 13.3 0.0 0.23 11.4 0.0 1.9 2 0 0 2 2 2 0 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_2 PF14560.6 EXF86328.1 - 0.16 12.4 0.1 0.54 10.8 0.0 1.9 2 0 0 2 2 2 0 Ubiquitin-like domain COesterase PF00135.28 EXF86329.1 - 9.7e-84 282.1 0.0 1.2e-83 281.8 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EXF86329.1 - 0.0002 21.3 0.3 0.00081 19.3 0.1 2.0 2 0 0 2 2 2 1 alpha/beta hydrolase fold SnoaL PF07366.12 EXF86330.1 - 0.0049 16.7 0.3 0.025 14.4 0.1 2.1 1 1 1 2 2 2 1 SnoaL-like polyketide cyclase Fer4_2 PF12797.7 EXF86331.1 - 0.15 12.2 0.6 0.15 12.2 0.6 2.7 3 0 0 3 3 3 0 4Fe-4S binding domain p450 PF00067.22 EXF86332.1 - 4.8e-71 239.9 0.0 9.1e-71 239.0 0.0 1.3 1 1 0 1 1 1 1 Cytochrome P450 MFS_1 PF07690.16 EXF86334.1 - 2.4e-41 141.9 49.0 1.5e-40 139.2 49.0 2.3 2 1 0 2 2 2 1 Major Facilitator Superfamily DUF1345 PF07077.11 EXF86334.1 - 0.01 15.5 3.5 0.025 14.3 2.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1345) Gemini_mov PF01708.16 EXF86334.1 - 9.3 6.1 5.8 68 3.3 2.0 3.1 3 1 1 4 4 4 0 Geminivirus putative movement protein MFS_1 PF07690.16 EXF86336.1 - 8e-29 100.7 31.0 1.2e-28 100.1 30.7 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF86336.1 - 1.5e-14 53.7 5.7 1.5e-14 53.7 5.7 2.3 3 1 0 3 3 3 1 Sugar (and other) transporter TRI12 PF06609.13 EXF86336.1 - 2.5e-06 26.2 5.8 4.9e-06 25.3 5.8 1.4 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Ank_4 PF13637.6 EXF86338.1 - 8.9e-14 51.7 2.2 0.0048 17.4 0.1 5.3 4 1 1 5 5 5 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 EXF86338.1 - 2.1e-12 47.4 0.7 7.5e-05 23.2 0.1 3.8 3 1 1 4 4 4 3 Ankyrin repeats (3 copies) Ank PF00023.30 EXF86338.1 - 1.3e-10 41.2 4.8 0.0019 18.6 0.1 5.2 6 0 0 6 6 6 2 Ankyrin repeat Ank_5 PF13857.6 EXF86338.1 - 2.1e-08 34.3 3.8 0.0074 16.6 0.2 5.0 5 0 0 5 5 5 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EXF86338.1 - 7e-07 29.1 0.8 0.1 13.2 0.0 4.3 4 0 0 4 4 4 2 Ankyrin repeat MFS_1 PF07690.16 EXF86339.1 - 1.7e-09 37.1 34.7 1.7e-09 37.1 34.7 2.0 1 1 0 2 2 2 1 Major Facilitator Superfamily F-box-like PF12937.7 EXF86339.1 - 8e-05 22.5 0.1 0.00022 21.0 0.1 1.8 1 0 0 1 1 1 1 F-box-like F-box_4 PF15966.5 EXF86339.1 - 0.054 13.4 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 F-box MFS_1 PF07690.16 EXF86341.1 - 9.9e-19 67.5 39.8 9.9e-19 67.5 39.8 1.8 1 1 0 1 1 1 1 Major Facilitator Superfamily MFS_1_like PF12832.7 EXF86341.1 - 0.00046 19.2 22.1 0.0074 15.2 7.4 3.0 1 1 2 3 3 3 2 MFS_1 like family DUF1449 PF07290.11 EXF86341.1 - 0.26 10.9 3.4 0.61 9.7 3.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1449) CDO_I PF05995.12 EXF86342.1 - 6.2e-40 136.3 0.2 1.3e-39 135.2 0.2 1.4 1 1 0 1 1 1 1 Cysteine dioxygenase type I PCO_ADO PF07847.12 EXF86342.1 - 0.0094 15.4 0.0 0.011 15.2 0.0 1.2 1 0 0 1 1 1 1 PCO_ADO 2OG-FeII_Oxy PF03171.20 EXF86343.1 - 1.3e-10 41.6 0.2 9.4e-09 35.7 0.0 2.4 1 1 1 2 2 2 2 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 EXF86343.1 - 1.9e-08 35.1 0.0 6.1e-08 33.4 0.0 1.8 2 0 0 2 2 2 1 non-haem dioxygenase in morphine synthesis N-terminal FAD_binding_4 PF01565.23 EXF86344.1 - 2.1e-23 82.6 1.0 5e-23 81.4 1.0 1.7 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EXF86344.1 - 0.071 13.2 0.0 0.17 12.0 0.0 1.6 1 0 0 1 1 1 0 Berberine and berberine like FAD_binding_4 PF01565.23 EXF86346.1 - 8.1e-09 35.3 0.2 1.3e-08 34.7 0.2 1.2 1 0 0 1 1 1 1 FAD binding domain Peptidase_M50B PF13398.6 EXF86346.1 - 5.3 6.6 5.0 7.5 6.1 5.0 1.2 1 0 0 1 1 1 0 Peptidase M50B-like ADH_zinc_N PF00107.26 EXF86347.1 - 1.9e-22 79.7 0.2 3.2e-22 78.9 0.2 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EXF86347.1 - 8.6e-14 52.7 0.0 1.4e-13 52.1 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EXF86347.1 - 2.4e-11 43.5 0.0 6.7e-10 38.8 0.0 2.4 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_N_2 PF16884.5 EXF86347.1 - 0.12 12.3 0.0 0.26 11.2 0.0 1.6 1 0 0 1 1 1 0 N-terminal domain of oxidoreductase DUF1283 PF06932.11 EXF86348.1 - 0.069 13.4 1.3 0.17 12.1 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1283) zf-C2H2 PF00096.26 EXF86349.1 - 6.7e-07 29.4 12.1 0.0042 17.4 1.1 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type Fungal_trans PF04082.18 EXF86349.1 - 9.2e-05 21.6 0.0 0.00027 20.1 0.0 1.8 1 1 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2_4 PF13894.6 EXF86349.1 - 0.00019 22.0 10.2 0.027 15.3 2.7 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EXF86349.1 - 0.49 10.9 13.3 0.17 12.4 1.8 3.6 3 0 0 3 3 3 0 Zinc-finger double domain zf-C2H2_11 PF16622.5 EXF86349.1 - 0.53 10.1 4.9 0.54 10.1 2.7 2.3 2 0 0 2 2 2 0 zinc-finger C2H2-type SLATT_1 PF18181.1 EXF86351.1 - 0.049 13.6 0.9 0.14 12.1 0.9 1.8 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain 1 NAD_binding_10 PF13460.6 EXF86352.1 - 6.7e-16 58.7 0.0 8.2e-16 58.4 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EXF86352.1 - 3e-13 49.9 0.0 4.5e-13 49.3 0.0 1.4 1 1 0 1 1 1 1 NmrA-like family KTSC PF13619.6 EXF86352.1 - 0.11 12.3 0.0 0.24 11.2 0.0 1.5 1 0 0 1 1 1 0 KTSC domain Epimerase PF01370.21 EXF86353.1 - 4.7e-13 49.2 0.0 1.6e-12 47.4 0.0 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 EXF86353.1 - 5.3e-12 45.4 0.1 4.3e-08 32.6 0.0 2.1 2 0 0 2 2 2 2 Male sterility protein 3Beta_HSD PF01073.19 EXF86353.1 - 7.2e-10 38.3 0.0 2.2e-09 36.7 0.0 1.7 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 EXF86353.1 - 1.3e-08 34.9 0.0 2.2e-08 34.2 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 EXF86353.1 - 1.6e-08 34.4 0.0 4.9e-08 32.7 0.0 1.7 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 EXF86353.1 - 4.2e-06 26.1 0.1 6.7e-06 25.4 0.1 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NmrA PF05368.13 EXF86353.1 - 0.0014 18.2 0.0 0.0019 17.8 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family Sacchrp_dh_NADP PF03435.18 EXF86353.1 - 0.0072 16.6 0.0 0.013 15.8 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain adh_short PF00106.25 EXF86353.1 - 0.15 11.5 0.0 0.75 9.2 0.0 2.1 2 0 0 2 2 2 0 short chain dehydrogenase FAD_binding_4 PF01565.23 EXF86355.1 - 9.5e-20 70.8 1.2 2.3e-19 69.5 1.2 1.7 1 0 0 1 1 1 1 FAD binding domain zf-NOSIP PF15906.5 EXF86355.1 - 0.16 12.1 0.0 0.38 10.9 0.0 1.5 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein Zn_clus PF00172.18 EXF86356.1 - 0.00036 20.6 4.1 0.00065 19.8 4.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain G_glu_transpept PF01019.21 EXF86356.1 - 0.023 13.5 0.6 0.43 9.3 0.1 2.3 2 1 0 2 2 2 0 Gamma-glutamyltranspeptidase FIVAR PF07554.13 EXF86356.1 - 0.46 11.3 2.9 53 4.7 0.1 3.1 3 0 0 3 3 3 0 FIVAR domain Amidase PF01425.21 EXF86358.1 - 8.4e-91 305.2 0.0 1.1e-90 304.8 0.0 1.1 1 0 0 1 1 1 1 Amidase IU_nuc_hydro PF01156.19 EXF86359.1 - 2.7e-19 69.9 0.0 3.8e-19 69.4 0.0 1.2 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase DJ-1_PfpI PF01965.24 EXF86360.1 - 5.4e-13 49.1 0.0 7.5e-13 48.6 0.0 1.1 1 0 0 1 1 1 1 DJ-1/PfpI family peroxidase PF00141.23 EXF86362.1 - 6.7e-30 104.5 0.0 1e-29 103.9 0.0 1.2 1 0 0 1 1 1 1 Peroxidase ANAPC4_WD40 PF12894.7 EXF86363.1 - 0.0069 16.7 0.0 0.74 10.2 0.0 3.1 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain PQ-loop PF04193.14 EXF86364.1 - 7.2e-15 54.5 8.2 1.4e-11 44.0 0.8 3.2 3 1 0 3 3 3 2 PQ loop repeat R3H-assoc PF13902.6 EXF86365.1 - 1e-24 87.4 1.8 1.9e-24 86.6 1.8 1.4 1 0 0 1 1 1 1 R3H-associated N-terminal domain CCD48 PF15799.5 EXF86365.1 - 0.049 11.9 2.9 0.087 11.1 2.5 1.6 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 48 DHHC PF01529.20 EXF86367.1 - 7.2e-06 26.1 2.7 1.1e-05 25.5 0.5 2.1 2 0 0 2 2 2 1 DHHC palmitoyltransferase F-box-like PF12937.7 EXF86368.1 - 2.4e-05 24.1 1.9 6.8e-05 22.7 1.9 1.8 1 0 0 1 1 1 1 F-box-like Ank_2 PF12796.7 EXF86368.1 - 0.036 14.7 0.2 0.8 10.3 0.1 3.0 2 2 0 3 3 3 0 Ankyrin repeats (3 copies) CFEM PF05730.11 EXF86369.1 - 0.033 14.3 2.4 1.5 9.0 0.4 2.1 2 0 0 2 2 2 0 CFEM domain CRAL_TRIO PF00650.20 EXF86371.1 - 3.7e-26 91.7 0.0 5.4e-26 91.2 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EXF86371.1 - 3.4e-09 36.7 0.0 7.8e-09 35.6 0.0 1.6 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain Acid_PPase PF12689.7 EXF86372.1 - 1.1e-65 220.7 0.0 1.2e-65 220.4 0.0 1.0 1 0 0 1 1 1 1 Acid Phosphatase Glyoxalase PF00903.25 EXF86373.1 - 1.7e-09 37.9 5.6 3.5e-06 27.2 2.2 2.8 2 1 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily TPR_2 PF07719.17 EXF86373.1 - 0.019 15.0 0.1 0.31 11.3 0.1 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_3 PF07720.12 EXF86373.1 - 0.055 13.5 1.4 0.58 10.2 0.1 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.28 EXF86373.1 - 0.074 12.9 0.5 0.81 9.6 0.1 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat SurE PF01975.17 EXF86374.1 - 1.2e-29 103.5 0.1 1.7e-29 103.0 0.1 1.2 1 0 0 1 1 1 1 Survival protein SurE Sulfotransfer_4 PF17784.1 EXF86375.1 - 7.3e-58 195.9 0.0 9.2e-58 195.6 0.0 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 EXF86375.1 - 0.00093 19.6 0.0 0.0016 18.9 0.0 1.4 1 0 0 1 1 1 1 Sulfotransferase family p450 PF00067.22 EXF86376.1 - 2.9e-58 197.7 0.0 3.3e-58 197.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 FAD_binding_3 PF01494.19 EXF86377.1 - 8.8e-24 84.4 0.0 1.2e-23 83.9 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 EXF86377.1 - 2.8e-10 40.3 2.5 0.00033 20.3 0.0 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EXF86377.1 - 1.3e-07 31.0 1.6 2.3e-07 30.3 1.6 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EXF86377.1 - 2.2e-07 30.4 0.8 1.8e-06 27.4 0.9 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EXF86377.1 - 7.9e-07 29.2 0.9 1.7e-06 28.1 0.4 1.8 2 0 0 2 2 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 EXF86377.1 - 2.8e-06 26.3 0.4 4.3e-05 22.4 0.3 2.0 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox PF00070.27 EXF86377.1 - 7.1e-05 23.3 0.2 0.009 16.5 0.1 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EXF86377.1 - 0.00025 20.5 2.3 0.00066 19.1 2.3 1.8 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EXF86377.1 - 0.00088 18.6 0.9 0.0051 16.1 1.3 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EXF86377.1 - 0.015 14.6 0.5 0.027 13.7 0.5 1.4 1 0 0 1 1 1 0 Thi4 family GIDA PF01134.22 EXF86377.1 - 0.019 14.1 0.8 0.035 13.2 0.8 1.4 2 0 0 2 2 2 0 Glucose inhibited division protein A Trp_halogenase PF04820.14 EXF86377.1 - 0.02 13.7 0.2 0.058 12.2 0.1 1.7 1 1 1 2 2 2 0 Tryptophan halogenase Amino_oxidase PF01593.24 EXF86377.1 - 0.034 13.4 0.2 0.17 11.2 0.0 2.0 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase Lycopene_cycl PF05834.12 EXF86377.1 - 0.055 12.5 1.9 0.55 9.2 1.5 2.0 2 0 0 2 2 2 0 Lycopene cyclase protein FMO-like PF00743.19 EXF86377.1 - 0.057 11.8 0.3 0.078 11.4 0.3 1.1 1 0 0 1 1 1 0 Flavin-binding monooxygenase-like AlaDh_PNT_C PF01262.21 EXF86377.1 - 0.14 11.4 1.8 0.31 10.3 0.9 1.9 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain Glyoxalase PF00903.25 EXF86378.1 - 2.9e-08 34.0 1.8 4.3e-05 23.7 0.4 2.5 2 1 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily FAA_hydrolase PF01557.18 EXF86379.1 - 9e-70 234.7 0.0 1.1e-69 234.5 0.0 1.0 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family DUF2437 PF10370.9 EXF86379.1 - 0.041 14.8 0.0 0.12 13.3 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF2437) Fungal_trans PF04082.18 EXF86380.1 - 1.4e-22 80.0 0.1 1.4e-22 80.0 0.1 2.0 1 1 0 2 2 2 1 Fungal specific transcription factor domain FAD_binding_3 PF01494.19 EXF86381.1 - 8.1e-69 232.5 0.0 1e-68 232.2 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 EXF86381.1 - 0.00063 18.6 0.0 0.0013 17.6 0.0 1.5 1 0 0 1 1 1 1 HI0933-like protein NAD_binding_8 PF13450.6 EXF86381.1 - 0.0014 18.8 0.1 0.0041 17.3 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EXF86381.1 - 0.0016 17.6 0.0 0.0029 16.8 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EXF86381.1 - 0.0017 17.7 0.0 0.0066 15.7 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EXF86381.1 - 0.0062 16.2 0.0 0.035 13.7 0.0 2.2 3 0 0 3 3 3 1 FAD dependent oxidoreductase GIDA PF01134.22 EXF86381.1 - 0.0074 15.4 0.0 0.012 14.8 0.0 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A Lycopene_cycl PF05834.12 EXF86381.1 - 0.0093 15.1 0.0 0.019 14.0 0.0 1.5 1 0 0 1 1 1 1 Lycopene cyclase protein FAD_oxidored PF12831.7 EXF86381.1 - 0.016 14.6 0.1 0.025 13.9 0.1 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EXF86381.1 - 0.017 14.4 0.1 0.044 13.0 0.0 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EXF86381.1 - 0.032 13.5 0.0 0.053 12.8 0.0 1.2 1 0 0 1 1 1 0 Thi4 family NAD_binding_9 PF13454.6 EXF86381.1 - 0.19 11.7 0.3 1.8 8.5 0.1 2.6 3 0 0 3 3 3 0 FAD-NAD(P)-binding Laminin_II PF06009.12 EXF86382.1 - 0.0065 16.5 2.5 0.024 14.6 0.7 2.0 1 1 1 2 2 2 1 Laminin Domain II DHR10 PF18595.1 EXF86382.1 - 0.036 14.1 0.2 0.06 13.4 0.2 1.3 1 0 0 1 1 1 0 Designed helical repeat protein 10 domain DUF948 PF06103.11 EXF86382.1 - 0.038 14.3 2.3 0.26 11.6 2.3 2.0 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Helo_like_N PF17111.5 EXF86382.1 - 0.043 13.2 0.5 0.073 12.4 0.5 1.4 1 0 0 1 1 1 0 Fungal N-terminal domain of STAND proteins BLOC1_2 PF10046.9 EXF86382.1 - 0.084 13.2 1.4 0.14 12.5 1.3 1.4 1 1 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 KxDL PF10241.9 EXF86382.1 - 0.093 13.0 1.1 0.17 12.1 0.7 1.6 1 1 0 1 1 1 0 Uncharacterized conserved protein BRE1 PF08647.11 EXF86382.1 - 0.17 12.0 2.0 0.19 11.8 0.7 1.7 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase DivIC PF04977.15 EXF86382.1 - 0.18 11.6 1.2 0.56 10.0 0.2 2.1 1 1 1 2 2 2 0 Septum formation initiator Caleosin PF05042.13 EXF86384.1 - 3e-78 261.6 0.4 3.7e-78 261.3 0.4 1.1 1 0 0 1 1 1 1 Caleosin related protein Glyco_hydro_3_C PF01915.22 EXF86385.1 - 5.8e-46 157.0 0.0 9.5e-46 156.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 EXF86385.1 - 6.3e-37 127.6 0.0 1.1e-36 126.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 EXF86385.1 - 8.8e-22 77.0 0.1 1.6e-21 76.2 0.1 1.4 1 0 0 1 1 1 1 Fibronectin type III-like domain HET PF06985.11 EXF86386.1 - 1.3e-26 93.7 0.0 3.8e-26 92.2 0.0 1.8 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) DUF1615 PF07759.12 EXF86386.1 - 0.13 11.5 0.0 0.2 10.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1615) D-ser_dehydrat PF14031.6 EXF86387.1 - 2.1e-22 79.6 0.0 4.2e-22 78.6 0.0 1.5 1 0 0 1 1 1 1 Putative serine dehydratase domain Ala_racemase_N PF01168.20 EXF86387.1 - 1.5e-11 44.4 0.2 2.3e-11 43.7 0.2 1.3 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain Radical_SAM PF04055.21 EXF86387.1 - 0.095 13.1 0.0 0.18 12.1 0.0 1.4 1 0 0 1 1 1 0 Radical SAM superfamily tRNA_SAD PF07973.14 EXF86388.1 - 3.4e-08 33.5 2.2 5.9e-08 32.7 0.9 2.0 2 0 0 2 2 2 1 Threonyl and Alanyl tRNA synthetase second additional domain tRNA-synt_2c PF01411.19 EXF86388.1 - 0.11 11.0 0.0 0.19 10.2 0.0 1.3 1 0 0 1 1 1 0 tRNA synthetases class II (A) Aa_trans PF01490.18 EXF86389.1 - 2.5e-44 151.6 34.3 2.9e-44 151.4 34.3 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein CAAD PF14159.6 EXF86389.1 - 0.035 13.9 0.4 0.035 13.9 0.4 3.0 3 0 0 3 3 3 0 CAAD domains of cyanobacterial aminoacyl-tRNA synthetase PAS_9 PF13426.7 EXF86391.1 - 6.9e-14 52.0 0.0 1.3e-12 47.9 0.0 2.6 2 0 0 2 2 2 1 PAS domain PAS_4 PF08448.10 EXF86391.1 - 9.5e-06 25.8 0.0 2.7e-05 24.4 0.0 1.8 1 0 0 1 1 1 1 PAS fold PAS PF00989.25 EXF86391.1 - 0.0016 18.4 0.0 0.007 16.4 0.0 2.1 2 0 0 2 2 2 1 PAS fold RGS PF00615.19 EXF86391.1 - 0.0046 17.2 0.2 0.081 13.2 0.2 2.5 1 1 0 1 1 1 1 Regulator of G protein signaling domain Ank_2 PF12796.7 EXF86392.1 - 9.7e-17 61.3 0.1 4.6e-05 23.9 0.0 5.5 4 1 1 5 5 5 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EXF86392.1 - 3.1e-12 46.8 0.6 0.5 11.0 0.0 7.2 5 2 2 7 7 7 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EXF86392.1 - 2.4e-11 43.7 0.8 0.12 12.7 0.0 6.1 4 1 2 6 6 6 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EXF86392.1 - 9.8e-11 40.9 2.5 0.0064 16.9 0.0 8.2 10 0 0 10 10 10 2 Ankyrin repeat Ank PF00023.30 EXF86392.1 - 6.4e-10 39.0 0.2 0.36 11.4 0.0 7.0 7 0 0 7 7 7 2 Ankyrin repeat GDI PF00996.18 EXF86392.1 - 0.058 11.9 0.0 0.094 11.2 0.0 1.2 1 0 0 1 1 1 0 GDP dissociation inhibitor Pkinase PF00069.25 EXF86393.1 - 6e-12 45.5 0.0 8.1e-12 45.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF86393.1 - 5.7e-09 35.6 0.0 8.2e-09 35.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase BK_channel_a PF03493.18 EXF86393.1 - 0.11 12.7 0.0 0.22 11.7 0.0 1.4 1 0 0 1 1 1 0 Calcium-activated BK potassium channel alpha subunit APH PF01636.23 EXF86393.1 - 0.17 11.8 0.1 8.1 6.3 0.0 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family Pkinase PF00069.25 EXF86394.1 - 1.3e-18 67.3 0.0 2.2e-18 66.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF86394.1 - 2.3e-11 43.5 0.0 3.4e-11 42.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase ThrE PF06738.12 EXF86395.1 - 7.3e-64 215.4 27.8 6.4e-61 205.8 4.6 3.0 2 1 0 2 2 2 2 Putative threonine/serine exporter ThrE_2 PF12821.7 EXF86395.1 - 1.8e-12 47.5 35.2 1.7e-11 44.4 14.8 2.5 2 0 0 2 2 2 2 Threonine/Serine exporter, ThrE DUF2651 PF10852.8 EXF86395.1 - 0.038 14.6 1.4 0.12 13.1 1.4 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2651) Acyl_transf_3 PF01757.22 EXF86396.1 - 1.9e-23 83.1 31.6 3.8e-21 75.5 20.9 3.0 2 2 0 2 2 2 2 Acyltransferase family Gamma-thionin PF00304.20 EXF86397.1 - 2.1 8.7 28.2 0.65 10.3 3.8 3.5 3 0 0 3 3 3 0 Gamma-thionin family Colipase PF01114.18 EXF86397.1 - 5.2 6.8 29.6 0.26 11.0 4.9 3.4 3 0 0 3 3 3 0 Colipase, N-terminal domain Methyltransf_23 PF13489.6 EXF86398.1 - 7.7e-25 87.6 0.0 1.2e-24 87.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF86398.1 - 7.2e-12 45.9 0.0 3.3e-11 43.7 0.0 2.1 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF86398.1 - 4.5e-09 36.9 0.0 4.6e-08 33.7 0.0 2.6 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF86398.1 - 3.5e-08 33.4 0.0 1.8e-07 31.1 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF86398.1 - 3.6e-08 33.9 0.0 9.4e-08 32.6 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EXF86398.1 - 0.0049 16.4 0.0 0.02 14.4 0.0 2.0 3 0 0 3 3 3 1 Methyltransferase small domain FtsJ PF01728.19 EXF86398.1 - 0.0073 16.4 0.0 0.01 15.9 0.0 1.4 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_16 PF10294.9 EXF86398.1 - 0.15 11.7 0.0 0.25 11.0 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase Ubie_methyltran PF01209.18 EXF86398.1 - 0.18 11.1 0.0 23 4.2 0.0 2.4 2 1 0 2 2 2 0 ubiE/COQ5 methyltransferase family Transferase PF02458.15 EXF86399.1 - 1.8e-07 30.2 0.0 0.002 16.8 0.0 2.3 2 0 0 2 2 2 2 Transferase family zf-UBP PF02148.19 EXF86399.1 - 0.14 12.5 1.4 0.43 11.0 1.4 1.7 1 0 0 1 1 1 0 Zn-finger in ubiquitin-hydrolases and other protein CLP1_P PF16575.5 EXF86400.1 - 3.3e-36 124.9 0.0 5.7e-36 124.1 0.0 1.4 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop CLP1_N PF16573.5 EXF86400.1 - 1.7e-27 95.4 0.0 3.1e-27 94.6 0.0 1.4 1 0 0 1 1 1 1 N-terminal beta-sandwich domain of polyadenylation factor Clp1 PF06807.14 EXF86400.1 - 5.3e-26 91.3 0.0 1.1e-25 90.3 0.0 1.6 1 0 0 1 1 1 1 Pre-mRNA cleavage complex II protein Clp1 AAA_33 PF13671.6 EXF86400.1 - 0.0004 20.6 0.0 0.0009 19.4 0.0 1.6 1 1 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 EXF86400.1 - 0.00041 20.4 0.1 0.003 17.6 0.1 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase ATP_bind_1 PF03029.17 EXF86400.1 - 0.0017 18.2 0.1 0.0036 17.1 0.1 1.5 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_24 PF13479.6 EXF86400.1 - 0.0095 15.7 0.0 0.019 14.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain FeoB_N PF02421.18 EXF86400.1 - 0.04 13.5 0.0 0.15 11.6 0.0 2.0 1 0 0 1 1 1 0 Ferrous iron transport protein B AAA_16 PF13191.6 EXF86400.1 - 0.063 13.7 0.0 0.11 12.9 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain KTI12 PF08433.10 EXF86400.1 - 0.078 12.4 0.0 0.69 9.3 0.0 2.0 2 0 0 2 2 2 0 Chromatin associated protein KTI12 IstB_IS21 PF01695.17 EXF86400.1 - 0.094 12.4 0.0 0.39 10.4 0.0 1.9 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_35 PF14516.6 EXF86400.1 - 0.096 11.5 0.0 0.15 10.8 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain AAA_28 PF13521.6 EXF86400.1 - 0.097 12.9 0.1 0.22 11.8 0.1 1.6 1 0 0 1 1 1 0 AAA domain Pmp3 PF01679.17 EXF86401.1 - 4.6e-20 71.6 9.1 5.8e-20 71.2 9.1 1.1 1 0 0 1 1 1 1 Proteolipid membrane potential modulator Arb1 PF09692.10 EXF86402.1 - 3.1e-127 425.1 0.0 3.6e-127 424.9 0.0 1.0 1 0 0 1 1 1 1 Argonaute siRNA chaperone (ARC) complex subunit Arb1 IPK PF03770.16 EXF86403.1 - 1.2e-51 175.4 0.0 1.5e-51 175.1 0.0 1.1 1 0 0 1 1 1 1 Inositol polyphosphate kinase OB_NTP_bind PF07717.16 EXF86404.1 - 9e-23 80.4 0.0 1.8e-22 79.5 0.0 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.23 EXF86404.1 - 5e-22 78.2 0.1 5e-22 78.2 0.1 2.8 3 0 0 3 3 3 1 Helicase associated domain (HA2) Helicase_C PF00271.31 EXF86404.1 - 6.9e-13 48.9 0.0 1.7e-12 47.7 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain S1 PF00575.23 EXF86404.1 - 3.4e-11 43.3 1.1 6.6e-11 42.4 1.1 1.5 1 0 0 1 1 1 1 S1 RNA binding domain AAA_22 PF13401.6 EXF86404.1 - 6.7e-08 32.9 0.0 1.6e-07 31.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain DEAD PF00270.29 EXF86404.1 - 1.6e-05 24.7 0.3 4.3e-05 23.4 0.3 1.7 1 1 0 1 1 1 1 DEAD/DEAH box helicase AAA_30 PF13604.6 EXF86404.1 - 0.00018 21.3 0.2 0.00049 19.9 0.2 1.6 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EXF86404.1 - 0.00073 19.9 0.3 0.0015 18.9 0.3 1.4 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 EXF86404.1 - 0.0024 17.0 0.0 0.0052 15.9 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein PhoH PF02562.16 EXF86404.1 - 0.058 12.8 0.0 0.15 11.5 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein DUF2075 PF09848.9 EXF86404.1 - 0.067 12.4 0.0 0.13 11.5 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) ABC_tran PF00005.27 EXF86404.1 - 0.1 13.1 0.1 1.4 9.4 0.1 2.5 1 1 1 2 2 2 0 ABC transporter AAA_14 PF13173.6 EXF86404.1 - 0.11 12.5 0.2 0.78 9.8 0.2 2.2 1 1 0 1 1 1 0 AAA domain Glyco_hydro_16 PF00722.21 EXF86406.1 - 0.00031 20.3 0.0 0.00073 19.0 0.0 1.6 1 1 0 1 1 1 1 Glycosyl hydrolases family 16 Reticulon PF02453.17 EXF86407.1 - 5.2e-18 65.5 0.0 8.1e-18 64.9 0.0 1.3 1 0 0 1 1 1 1 Reticulon FUSC_2 PF13515.6 EXF86407.1 - 0.06 13.5 1.3 1.8 8.7 0.1 2.2 2 0 0 2 2 2 0 Fusaric acid resistance protein-like DUF883 PF05957.13 EXF86407.1 - 1.2 9.8 6.2 8.7 7.0 5.3 2.7 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF883) YtxH PF12732.7 EXF86407.1 - 4.2 8.0 6.0 18 5.9 6.0 2.2 1 1 0 1 1 1 0 YtxH-like protein Alginate_lyase PF05426.12 EXF86408.1 - 7.4e-20 71.6 0.1 1.4e-19 70.7 0.1 1.4 1 1 0 1 1 1 1 Alginate lyase GLEYA PF10528.9 EXF86409.1 - 8.7e-47 157.5 19.8 2.5e-28 98.3 6.6 3.4 2 1 1 3 3 3 2 GLEYA domain PA14 PF07691.12 EXF86409.1 - 2.4e-23 82.6 0.5 7.2e-11 42.1 0.7 2.6 2 0 0 2 2 2 2 PA14 domain C1q PF00386.21 EXF86409.1 - 1.9 8.7 8.7 5.6 7.2 1.1 2.4 2 0 0 2 2 2 0 C1q domain Romo1 PF10247.9 EXF86409.1 - 5.3 7.5 9.2 2.3e+02 2.2 0.0 5.6 6 0 0 6 6 6 0 Reactive mitochondrial oxygen species modulator 1 Curlin_rpt PF07012.12 EXF86410.1 - 2.4 8.2 8.9 4.2 7.5 4.8 2.5 2 0 0 2 2 2 0 Curlin associated repeat Ashwin PF15323.6 EXF86410.1 - 8.9 6.3 9.0 24 4.9 9.0 1.7 1 1 0 1 1 1 0 Developmental protein Glyco_hydro_28 PF00295.17 EXF86411.1 - 1e-09 38.0 5.5 1.7e-09 37.2 4.7 1.6 1 1 0 1 1 1 1 Glycosyl hydrolases family 28 Beta_helix PF13229.6 EXF86411.1 - 0.002 18.0 16.9 0.07 13.0 16.9 2.8 1 1 0 1 1 1 1 Right handed beta helix region HATPase_c_4 PF13749.6 EXF86411.1 - 0.1 12.8 0.0 0.18 11.9 0.0 1.4 1 0 0 1 1 1 0 Putative ATP-dependent DNA helicase recG C-terminal NRBF2 PF08961.10 EXF86413.1 - 0.22 11.1 0.0 0.26 10.9 0.0 1.1 1 0 0 1 1 1 0 Nuclear receptor-binding factor 2, autophagy regulator Beta-lactamase PF00144.24 EXF86414.1 - 6.3e-42 144.0 0.0 8.7e-42 143.5 0.0 1.1 1 0 0 1 1 1 1 Beta-lactamase Beta-lactamase2 PF13354.6 EXF86414.1 - 0.00019 21.1 0.0 0.0018 17.9 0.0 2.0 2 0 0 2 2 2 1 Beta-lactamase enzyme family DEAD PF00270.29 EXF86415.1 - 7.4e-47 159.4 0.0 1.9e-46 158.1 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF4217 PF13959.6 EXF86415.1 - 1.3e-22 79.7 0.0 3.1e-22 78.5 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) Helicase_C PF00271.31 EXF86415.1 - 1.1e-21 77.2 0.0 1.6e-20 73.5 0.0 2.8 1 1 1 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EXF86415.1 - 1.5e-07 31.6 0.0 3.8e-07 30.3 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit MRI PF15325.6 EXF86415.1 - 5 8.3 12.0 1.5 10.0 0.3 3.6 3 0 0 3 3 3 0 Modulator of retrovirus infection Sad1_UNC PF07738.13 EXF86416.1 - 7.2e-09 35.7 0.0 4e-08 33.4 0.0 2.0 1 1 0 1 1 1 1 Sad1 / UNC-like C-terminal DUF445 PF04286.12 EXF86416.1 - 0.077 12.8 1.6 1.2 8.9 2.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF445) PP2C_C PF07830.13 EXF86416.1 - 0.15 12.5 0.9 1.7 9.2 0.1 2.7 2 0 0 2 2 2 0 Protein serine/threonine phosphatase 2C, C-terminal domain GDP_Man_Dehyd PF16363.5 EXF86417.1 - 6.3e-49 167.2 0.0 1.1e-48 166.4 0.0 1.4 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 EXF86417.1 - 1.3e-46 159.0 0.0 1.9e-46 158.5 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EXF86417.1 - 4.9e-19 68.4 0.1 3.1e-18 65.8 0.0 1.9 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 EXF86417.1 - 8.8e-16 57.9 0.0 1.1e-13 51.0 0.0 2.2 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 EXF86417.1 - 2.8e-12 46.3 0.0 4.1e-12 45.8 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain adh_short PF00106.25 EXF86417.1 - 1.2e-10 41.2 0.0 1.9e-10 40.5 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EXF86417.1 - 6.1e-09 36.0 0.0 1.1e-08 35.3 0.0 1.4 1 0 0 1 1 1 1 KR domain NAD_binding_4 PF07993.12 EXF86417.1 - 3.4e-07 29.7 0.0 1.6e-06 27.5 0.0 1.9 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.6 EXF86417.1 - 8.1e-05 22.6 0.0 0.00013 21.9 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding adh_short_C2 PF13561.6 EXF86417.1 - 0.0015 18.1 0.0 0.0026 17.3 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase UDPG_MGDP_dh_N PF03721.14 EXF86417.1 - 0.013 15.1 0.0 0.022 14.4 0.0 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NmrA PF05368.13 EXF86417.1 - 0.016 14.8 0.0 0.036 13.6 0.0 1.6 2 0 0 2 2 2 0 NmrA-like family ADH_zinc_N PF00107.26 EXF86418.1 - 1.7e-30 105.6 0.2 2.8e-30 104.9 0.2 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EXF86418.1 - 2.8e-22 80.2 0.0 4.9e-22 79.4 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EXF86418.1 - 1.9e-09 37.4 0.0 1.2e-08 34.8 0.0 2.2 2 1 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_N_2 PF16884.5 EXF86418.1 - 0.0028 17.5 0.0 0.0071 16.2 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase adh_short PF00106.25 EXF86418.1 - 0.0091 15.5 1.6 0.022 14.2 1.6 1.7 1 1 0 1 1 1 1 short chain dehydrogenase HupF_HypC PF01455.18 EXF86418.1 - 0.096 12.9 0.0 0.25 11.5 0.0 1.7 1 0 0 1 1 1 0 HupF/HypC family EutK_C PF16365.5 EXF86418.1 - 0.17 11.9 0.0 0.63 10.1 0.0 1.9 2 0 0 2 2 2 0 Ethanolamine utilization protein EutK C-terminus Ank_2 PF12796.7 EXF86419.1 - 9.5e-42 141.5 18.3 8.4e-06 26.3 0.0 14.8 13 2 2 15 15 15 13 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EXF86419.1 - 5.4e-18 65.1 16.8 0.46 11.1 0.1 15.6 15 4 3 18 18 18 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EXF86419.1 - 6.8e-15 53.7 22.1 0.0031 17.9 0.0 18.2 24 1 1 25 25 25 2 Ankyrin repeat Ank_5 PF13857.6 EXF86419.1 - 5.5e-13 48.9 9.8 2.5e-06 27.6 0.0 11.2 14 0 0 14 14 14 2 Ankyrin repeats (many copies) Ank PF00023.30 EXF86419.1 - 5.5e-09 36.1 36.9 0.00044 20.6 0.0 16.0 18 1 1 19 19 19 2 Ankyrin repeat Ribosomal_S30 PF04758.14 EXF86421.1 - 0.16 12.2 14.0 1e+02 3.2 0.0 7.4 2 1 6 11 11 11 0 Ribosomal protein S30 Peptidase_M28 PF04389.17 EXF86422.1 - 1.1e-36 126.5 0.0 1.5e-36 125.9 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 EXF86422.1 - 2.2e-14 53.2 0.9 5.4e-14 52.0 0.9 1.7 1 0 0 1 1 1 1 PA domain Peptidase_M20 PF01546.28 EXF86422.1 - 9.6e-06 25.4 0.1 2e-05 24.4 0.1 1.6 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Peroxidase_2 PF01328.17 EXF86423.1 - 3.2e-49 168.0 0.0 4e-49 167.7 0.0 1.1 1 0 0 1 1 1 1 Peroxidase, family 2 Tyrosinase PF00264.20 EXF86424.1 - 4.5e-54 184.1 0.4 6e-54 183.7 0.4 1.1 1 0 0 1 1 1 1 Common central domain of tyrosinase Methyltransf_23 PF13489.6 EXF86425.1 - 1.3e-18 67.4 0.0 2e-18 66.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF86425.1 - 2.9e-14 53.5 0.0 1.7e-13 51.1 0.0 2.3 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF86425.1 - 7.9e-12 45.7 0.0 1.9e-11 44.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF86425.1 - 1.6e-09 38.4 0.0 1.4e-08 35.4 0.0 2.6 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF86425.1 - 2.3e-09 37.2 0.0 5.8e-08 32.7 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EXF86425.1 - 1.2e-06 28.0 0.0 2e-05 24.1 0.0 2.6 2 1 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_2 PF00891.18 EXF86425.1 - 0.00064 19.1 0.0 0.0013 18.1 0.0 1.6 1 1 0 1 1 1 1 O-methyltransferase domain MTS PF05175.14 EXF86425.1 - 0.0015 18.1 0.0 0.013 15.1 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_4 PF02390.17 EXF86425.1 - 0.017 14.6 0.0 0.14 11.6 0.0 2.3 3 0 0 3 3 3 0 Putative methyltransferase PrmA PF06325.13 EXF86425.1 - 0.049 13.0 0.0 0.076 12.4 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) CMAS PF02353.20 EXF86425.1 - 0.093 12.0 0.0 0.15 11.3 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_16 PF10294.9 EXF86425.1 - 0.13 12.0 0.0 0.23 11.2 0.0 1.4 1 0 0 1 1 1 0 Lysine methyltransferase Methyltransf_8 PF05148.15 EXF86425.1 - 0.21 11.4 0.0 0.36 10.6 0.0 1.4 1 0 0 1 1 1 0 Hypothetical methyltransferase 7tm_3 PF00003.22 EXF86426.1 - 0.0012 18.6 2.7 0.0058 16.4 2.7 1.9 1 1 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR DUF4395 PF14340.6 EXF86426.1 - 0.96 9.8 5.5 2.2 8.6 0.8 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF4395) MIP PF00230.20 EXF86427.1 - 2.8e-41 141.7 13.9 3.4e-41 141.4 13.9 1.1 1 0 0 1 1 1 1 Major intrinsic protein Sugar_tr PF00083.24 EXF86428.1 - 1.3e-68 231.9 14.2 4.8e-67 226.8 14.2 2.0 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF86428.1 - 6.6e-12 45.0 39.4 4.7e-07 29.1 11.7 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF4212 PF13937.6 EXF86428.1 - 0.0018 18.6 4.5 0.012 15.9 0.2 3.6 3 0 0 3 3 3 1 Domain of unknown function (DUF4212) Ank_2 PF12796.7 EXF86429.1 - 4.6e-21 75.2 0.7 1.6e-07 31.8 0.0 4.2 2 2 3 5 5 5 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EXF86429.1 - 1.1e-14 54.2 0.1 5.7e-06 26.5 0.0 3.9 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 EXF86429.1 - 3.4e-14 52.6 0.0 0.0012 19.2 0.0 4.2 3 0 0 3 3 3 3 Ankyrin repeat Ank_3 PF13606.6 EXF86429.1 - 1.1e-13 49.9 0.0 0.0012 19.1 0.0 5.5 6 0 0 6 6 6 2 Ankyrin repeat Ank_4 PF13637.6 EXF86429.1 - 2.4e-12 47.1 0.1 0.0011 19.4 0.0 4.8 4 1 1 5 5 5 3 Ankyrin repeats (many copies) Helo_like_N PF17111.5 EXF86429.1 - 7.1e-12 45.1 2.4 1.6e-11 44.0 2.4 1.6 1 0 0 1 1 1 1 Fungal N-terminal domain of STAND proteins SesA PF17107.5 EXF86429.1 - 0.00014 22.1 0.3 0.00055 20.1 0.3 2.1 1 0 0 1 1 1 1 N-terminal domain on NACHT_NTPase and P-loop NTPases Peptidase_M28 PF04389.17 EXF86430.1 - 1.3e-39 135.9 0.0 2.5e-39 135.1 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 EXF86430.1 - 6.4e-11 42.1 0.5 1.8e-10 40.7 0.1 1.9 2 0 0 2 2 2 1 PA domain Peptidase_M20 PF01546.28 EXF86430.1 - 0.00037 20.2 0.0 0.00064 19.5 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 MFS_1 PF07690.16 EXF86431.1 - 4.5e-30 104.8 17.6 8.8e-29 100.5 16.3 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily TauD PF02668.16 EXF86433.1 - 8e-35 120.9 0.0 1.2e-34 120.4 0.0 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family UL16 PF17622.2 EXF86433.1 - 0.038 13.6 0.0 0.062 12.9 0.0 1.3 1 0 0 1 1 1 0 Viral unique long protein 16 Ax_dynein_light PF10211.9 EXF86433.1 - 0.057 13.4 0.0 0.096 12.6 0.0 1.3 1 0 0 1 1 1 0 Axonemal dynein light chain MFS_1 PF07690.16 EXF86434.1 - 3.8e-17 62.3 7.0 5.1e-17 61.8 7.0 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EXF86434.1 - 0.0033 16.3 3.9 0.0042 16.0 3.9 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter TnpB_IS66 PF05717.13 EXF86435.1 - 0.077 12.9 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 IS66 Orf2 like protein Abhydrolase_1 PF00561.20 EXF86436.1 - 1.5e-19 70.6 0.1 2.4e-19 70.0 0.1 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EXF86436.1 - 2.3e-15 57.8 4.0 3.1e-15 57.4 4.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EXF86436.1 - 1.6e-08 34.2 0.0 2.2e-08 33.7 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Ser_hydrolase PF06821.13 EXF86436.1 - 0.071 13.0 0.1 0.16 11.8 0.1 1.6 1 0 0 1 1 1 0 Serine hydrolase Methyltransf_23 PF13489.6 EXF86437.1 - 9.3e-18 64.6 0.0 1.8e-17 63.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF86437.1 - 8.2e-09 36.1 0.0 3.2e-08 34.2 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF86437.1 - 3e-07 31.0 0.0 7.7e-07 29.7 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain HNH_2 PF13391.6 EXF86437.1 - 4.1e-07 30.0 0.2 9.2e-07 28.9 0.2 1.6 1 0 0 1 1 1 1 HNH endonuclease Methyltransf_31 PF13847.6 EXF86437.1 - 5.4e-07 29.5 0.0 0.01 15.7 0.0 2.6 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 EXF86437.1 - 3.5e-06 27.7 0.1 5.8e-05 23.8 0.0 2.7 2 1 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 EXF86437.1 - 0.035 13.6 0.0 0.077 12.5 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase small domain DUF4979 PF16351.5 EXF86437.1 - 0.12 12.5 0.1 0.23 11.7 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4979) PrmA PF06325.13 EXF86437.1 - 0.16 11.3 0.0 0.28 10.5 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_2 PF00891.18 EXF86437.1 - 0.19 11.0 0.0 0.35 10.1 0.0 1.4 1 0 0 1 1 1 0 O-methyltransferase domain DUF3135 PF11333.8 EXF86437.1 - 0.19 12.0 0.8 3.8 7.8 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3135) Oxidored_FMN PF00724.20 EXF86438.1 - 3.2e-63 214.1 0.0 4.1e-63 213.7 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Dus PF01207.17 EXF86438.1 - 4.9e-05 22.6 0.0 0.0001 21.5 0.0 1.6 1 1 0 1 1 1 1 Dihydrouridine synthase (Dus) FMN_dh PF01070.18 EXF86438.1 - 0.04 13.0 3.5 0.037 13.0 2.2 1.6 2 0 0 2 2 2 0 FMN-dependent dehydrogenase His_biosynth PF00977.21 EXF86438.1 - 0.046 13.2 0.0 0.076 12.5 0.0 1.3 1 0 0 1 1 1 0 Histidine biosynthesis protein DHO_dh PF01180.21 EXF86438.1 - 0.14 11.4 0.0 0.19 10.9 0.0 1.3 1 0 0 1 1 1 0 Dihydroorotate dehydrogenase Zn_clus PF00172.18 EXF86439.1 - 2.6e-09 37.1 11.6 4.6e-09 36.3 11.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EXF86439.1 - 0.001 18.2 0.0 0.0016 17.5 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Spc29 PF17082.5 EXF86439.1 - 0.021 14.7 0.2 0.05 13.5 0.0 1.6 2 0 0 2 2 2 0 Spindle Pole Component 29 Trimer_CC PF08954.11 EXF86439.1 - 0.53 9.9 3.0 1.5 8.5 3.0 1.8 1 0 0 1 1 1 0 Trimerisation motif Sld5 PF05916.11 EXF86440.1 - 1.8e-31 108.8 0.0 3.1e-31 108.0 0.0 1.4 1 0 0 1 1 1 1 GINS complex protein DUF1445 PF07286.12 EXF86442.1 - 3.1e-62 208.7 0.1 4.2e-62 208.3 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1445) Imm72 PF15584.6 EXF86442.1 - 0.042 14.0 0.0 0.083 13.0 0.0 1.5 1 0 0 1 1 1 0 Immunity protein 72 Aldo_ket_red PF00248.21 EXF86443.1 - 6.6e-68 229.0 0.0 7.5e-68 228.9 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Rhomboid PF01694.22 EXF86444.1 - 0.0033 17.5 3.9 0.017 15.1 3.0 2.5 1 1 0 1 1 1 1 Rhomboid family DUF4218 PF13960.6 EXF86444.1 - 6.9 6.3 8.3 13 5.5 0.0 3.3 2 1 2 4 4 4 0 Domain of unknown function (DUF4218) SNF2_N PF00176.23 EXF86445.1 - 5e-64 216.2 0.2 2.7e-63 213.8 0.0 2.0 1 1 1 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EXF86445.1 - 4.2e-23 81.8 0.0 1.8e-22 79.7 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EXF86445.1 - 4.5e-08 33.3 0.4 2.6e-07 30.8 0.0 2.5 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EXF86445.1 - 0.00019 21.3 0.0 0.00079 19.2 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase ERCC3_RAD25_C PF16203.5 EXF86445.1 - 0.00028 20.2 0.0 0.00028 20.2 0.0 1.9 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase SWI2_SNF2 PF18766.1 EXF86445.1 - 0.006 16.3 0.7 0.012 15.2 0.0 2.0 2 0 0 2 2 2 1 SWI2/SNF2 ATPase SPT2 PF08243.11 EXF86445.1 - 0.02 15.4 3.6 0.02 15.4 3.6 3.8 3 1 0 3 3 3 0 SPT2 chromatin protein tRNA_bind PF01588.20 EXF86446.1 - 2.9e-23 81.8 0.2 6.5e-23 80.7 0.2 1.6 1 0 0 1 1 1 1 Putative tRNA binding domain GST_C_2 PF13410.6 EXF86446.1 - 2.1e-05 24.4 0.0 3.9e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EXF86446.1 - 0.00023 21.3 1.0 0.0087 16.3 0.0 2.7 2 1 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EXF86446.1 - 0.024 14.8 0.0 0.052 13.7 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain HSP9_HSP12 PF04119.12 EXF86446.1 - 0.045 14.2 3.0 0.12 12.8 3.0 1.8 1 0 0 1 1 1 0 Heat shock protein 9/12 UPF0240 PF06784.11 EXF86446.1 - 0.053 13.6 0.4 0.093 12.8 0.4 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0240) GST_C_6 PF17171.4 EXF86446.1 - 0.1 12.4 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain NUC153 PF08159.12 EXF86448.1 - 2.8e-13 49.4 0.7 2.8e-13 49.4 0.7 3.2 3 0 0 3 3 3 1 NUC153 domain SNF2_N PF00176.23 EXF86449.1 - 7.7e-37 126.8 0.0 3.7e-36 124.6 0.0 1.9 1 1 1 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EXF86449.1 - 1.5e-13 51.1 0.0 4.2e-13 49.6 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EXF86449.1 - 1.1e-06 28.8 0.2 2.6e-05 24.3 0.0 3.0 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit zf-C3HC4_2 PF13923.6 EXF86449.1 - 8.8e-06 25.5 3.8 1.9e-05 24.4 3.8 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EXF86449.1 - 2e-05 24.5 4.5 4.9e-05 23.3 4.5 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EXF86449.1 - 0.0017 18.2 6.8 0.0042 16.9 6.8 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EXF86449.1 - 0.0058 16.9 9.7 0.013 15.8 9.7 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_6 PF14835.6 EXF86449.1 - 0.0068 16.3 2.4 0.016 15.0 2.4 1.6 1 0 0 1 1 1 1 zf-RING of BARD1-type protein ERCC3_RAD25_C PF16203.5 EXF86449.1 - 0.008 15.4 0.1 0.02 14.1 0.1 1.6 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Prok-RING_4 PF14447.6 EXF86449.1 - 0.0096 15.8 3.3 0.023 14.5 3.3 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 EXF86449.1 - 0.012 15.7 3.5 0.028 14.6 3.5 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 EXF86449.1 - 0.073 13.0 7.4 0.16 11.9 7.4 1.6 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_10 PF16685.5 EXF86449.1 - 0.54 10.4 4.4 5.2 7.3 5.1 2.2 2 0 0 2 2 2 0 zinc RING finger of MSL2 Git3 PF11710.8 EXF86450.1 - 4.9e-65 219.1 11.2 8.5e-65 218.3 11.2 1.3 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 GPR_Gpa2_C PF11970.8 EXF86450.1 - 2.3e-13 50.0 0.1 6.2e-13 48.6 0.1 1.7 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 C-term 7tm_1 PF00001.21 EXF86450.1 - 2.3e-08 33.7 0.0 3.1e-08 33.3 0.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF4381 PF14316.6 EXF86450.1 - 0.95 9.7 7.5 4.1 7.7 1.6 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4381) SNF2_N PF00176.23 EXF86451.1 - 1.2e-40 139.4 0.2 9e-40 136.5 0.2 2.1 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EXF86451.1 - 1.2e-13 51.4 0.0 1.4e-11 44.7 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 EXF86451.1 - 3e-07 29.9 0.1 9.1e-07 28.3 0.0 1.8 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase zf-C3HC4_3 PF13920.6 EXF86451.1 - 6.8e-07 29.0 7.4 1.7e-06 27.8 7.4 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EXF86451.1 - 8.7e-06 25.5 10.7 2e-05 24.3 10.7 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) ResIII PF04851.15 EXF86451.1 - 2.3e-05 24.5 0.0 2.3e-05 24.5 0.0 2.1 3 0 0 3 3 2 1 Type III restriction enzyme, res subunit zf-C3HC4_2 PF13923.6 EXF86451.1 - 3.5e-05 23.6 10.5 0.00011 21.9 10.5 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EXF86451.1 - 0.00021 21.6 8.9 0.00061 20.1 8.9 1.9 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 EXF86451.1 - 0.0013 18.6 10.5 0.0035 17.3 10.5 1.8 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EXF86451.1 - 0.0037 17.1 8.4 0.0037 17.1 8.4 1.9 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 EXF86451.1 - 0.011 15.7 9.6 0.031 14.3 9.6 1.8 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_4 PF15227.6 EXF86451.1 - 0.029 14.5 7.6 0.16 12.1 8.5 1.9 2 0 0 2 2 1 0 zinc finger of C3HC4-type, RING zf-RING_6 PF14835.6 EXF86451.1 - 0.041 13.8 2.3 0.093 12.6 2.3 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-RING_10 PF16685.5 EXF86451.1 - 0.052 13.7 7.4 0.26 11.4 7.4 2.1 2 0 0 2 2 2 0 zinc RING finger of MSL2 zf-RING_4 PF14570.6 EXF86451.1 - 0.074 12.9 6.8 0.33 10.8 7.0 2.0 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-rbx1 PF12678.7 EXF86451.1 - 0.084 13.2 9.8 0.027 14.7 6.1 2.2 2 0 0 2 2 1 0 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 EXF86451.1 - 0.2 11.7 2.7 0.73 9.9 2.7 2.1 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger KIND PF16474.5 EXF86451.1 - 4.9 7.0 8.8 18 5.2 1.6 2.7 2 0 0 2 2 2 0 Kinase non-catalytic C-lobe domain GATase PF00117.28 EXF86452.1 - 5.6e-12 45.8 0.0 7.7e-12 45.4 0.0 1.1 1 0 0 1 1 1 1 Glutamine amidotransferase class-I GATase_3 PF07685.14 EXF86452.1 - 0.19 11.3 0.0 0.27 10.8 0.0 1.3 1 0 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain DHHA2 PF02833.14 EXF86453.1 - 1.9e-35 122.1 0.1 2.9e-35 121.5 0.1 1.3 1 0 0 1 1 1 1 DHHA2 domain DHH PF01368.20 EXF86453.1 - 2.2e-11 43.9 0.0 1.4e-10 41.3 0.0 2.0 1 1 1 2 2 2 1 DHH family Mitofilin PF09731.9 EXF86453.1 - 0.16 10.8 0.0 0.22 10.3 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein S1-P1_nuclease PF02265.16 EXF86454.1 - 4.4e-67 226.5 0.0 5e-67 226.4 0.0 1.0 1 0 0 1 1 1 1 S1/P1 Nuclease YjeF_N PF03853.15 EXF86454.1 - 0.049 13.5 0.0 0.085 12.7 0.0 1.4 1 0 0 1 1 1 0 YjeF-related protein N-terminus RsfS PF02410.15 EXF86455.1 - 1.6e-12 47.7 0.0 4.2e-12 46.4 0.0 1.8 1 0 0 1 1 1 1 Ribosomal silencing factor during starvation HTH_31 PF13560.6 EXF86455.1 - 0.079 13.3 0.6 16 6.0 0.0 2.9 3 0 0 3 3 3 0 Helix-turn-helix domain TIMELESS PF04821.14 EXF86455.1 - 0.084 12.1 0.1 0.6 9.3 0.0 2.0 2 0 0 2 2 2 0 Timeless protein BBP1_C PF15272.6 EXF86455.1 - 0.093 12.5 0.2 0.18 11.6 0.2 1.4 1 0 0 1 1 1 0 Spindle pole body component BBP1, C-terminal RNA_pol PF00940.19 EXF86456.1 - 8.6e-187 621.0 0.0 1.2e-186 620.5 0.0 1.2 1 0 0 1 1 1 1 DNA-dependent RNA polymerase RPOL_N PF14700.6 EXF86456.1 - 8.2e-106 354.2 1.0 8.2e-106 354.2 1.0 1.8 2 0 0 2 2 2 1 DNA-directed RNA polymerase N-terminal Methyltransf_23 PF13489.6 EXF86457.1 - 8.1e-13 48.5 0.0 1.1e-12 48.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF86457.1 - 2.1e-05 24.4 0.0 3.1e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF86457.1 - 0.00038 21.1 0.0 0.0015 19.2 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF86457.1 - 0.00058 20.5 0.0 0.0012 19.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF86457.1 - 0.002 18.8 0.0 0.0044 17.7 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Ank_4 PF13637.6 EXF86458.1 - 2.3e-15 56.8 0.1 6.8e-09 36.1 0.0 3.1 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 EXF86458.1 - 7.1e-15 54.9 0.0 7.1e-10 39.0 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EXF86458.1 - 2.7e-11 43.9 0.4 6.3e-06 26.7 0.2 3.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EXF86458.1 - 4e-09 36.0 0.5 0.0047 17.3 0.0 4.7 4 1 0 4 4 4 2 Ankyrin repeat Ank PF00023.30 EXF86458.1 - 1.6e-08 34.6 0.4 0.0018 18.6 0.0 3.8 4 0 0 4 4 4 2 Ankyrin repeat p450 PF00067.22 EXF86459.1 - 2.7e-49 168.2 0.0 3.5e-49 167.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Methyltransf_23 PF13489.6 EXF86460.1 - 8.1e-22 77.8 0.0 1.1e-21 77.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EXF86460.1 - 2.1e-08 34.7 0.0 1.3e-07 32.2 0.0 2.3 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EXF86460.1 - 1.2e-05 25.9 0.0 3.2e-05 24.5 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EXF86460.1 - 4.8e-05 24.0 0.0 0.00063 20.4 0.0 2.5 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EXF86460.1 - 0.00017 21.4 0.0 0.19 11.5 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain FtsJ PF01728.19 EXF86460.1 - 0.0051 16.9 0.0 0.0087 16.2 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase PrmA PF06325.13 EXF86460.1 - 0.16 11.3 0.0 0.46 9.8 0.0 1.6 1 1 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) GMC_oxred_N PF00732.19 EXF86461.1 - 1.8e-63 214.7 0.0 2.3e-63 214.3 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EXF86461.1 - 1.5e-28 100.1 0.2 3.1e-28 99.1 0.2 1.6 1 0 0 1 1 1 1 GMC oxidoreductase Thi4 PF01946.17 EXF86461.1 - 9.5e-05 21.7 0.1 0.00023 20.5 0.1 1.6 1 0 0 1 1 1 1 Thi4 family FAD_binding_2 PF00890.24 EXF86461.1 - 0.00021 20.5 0.0 0.62 9.1 0.0 2.3 2 0 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 EXF86461.1 - 0.0037 17.5 0.0 0.012 15.9 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EXF86461.1 - 0.006 16.2 0.0 0.013 15.1 0.0 1.6 1 0 0 1 1 1 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 EXF86461.1 - 0.012 14.7 0.0 0.021 13.9 0.0 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein Pyr_redox_2 PF07992.14 EXF86461.1 - 0.033 13.4 0.0 4.3 6.5 0.0 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase MFS_1 PF07690.16 EXF86462.1 - 3e-11 42.9 54.1 1.2e-07 31.1 18.2 2.5 2 1 1 3 3 3 2 Major Facilitator Superfamily TRI12 PF06609.13 EXF86462.1 - 2.7e-06 26.1 27.0 5.7e-06 25.0 27.0 1.3 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) AA_permease PF00324.21 EXF86463.1 - 2.3e-119 399.1 32.2 2.6e-119 399.0 32.2 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EXF86463.1 - 2.5e-31 108.9 36.0 3.1e-31 108.7 36.0 1.0 1 0 0 1 1 1 1 Amino acid permease FpoO PF10621.9 EXF86464.1 - 0.12 12.7 1.5 0.13 12.5 1.0 1.4 1 1 0 1 1 1 0 F420H2 dehydrogenase subunit FpoO zf-TAZ PF02135.16 EXF86464.1 - 0.14 12.6 3.3 0.32 11.5 0.2 2.2 2 0 0 2 2 2 0 TAZ zinc finger GMC_oxred_N PF00732.19 EXF86465.1 - 5.2e-52 177.1 0.0 9.4e-52 176.2 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EXF86465.1 - 1e-36 126.6 0.0 1.8e-36 125.8 0.0 1.5 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.24 EXF86465.1 - 1.1e-08 34.6 2.1 0.00071 18.8 0.9 2.5 3 0 0 3 3 3 2 FAD binding domain DAO PF01266.24 EXF86465.1 - 2.3e-05 24.1 1.5 0.0015 18.2 1.0 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EXF86465.1 - 0.00028 20.2 0.3 0.00065 19.0 0.2 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EXF86465.1 - 0.00044 19.6 0.7 0.63 9.2 0.7 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EXF86465.1 - 0.002 17.2 1.1 0.002 17.2 0.1 1.5 2 0 0 2 2 2 1 Lycopene cyclase protein NAD_binding_8 PF13450.6 EXF86465.1 - 0.0035 17.5 2.1 0.012 15.9 2.1 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 EXF86465.1 - 0.0066 15.2 1.3 0.011 14.5 0.6 1.6 2 0 0 2 2 2 1 HI0933-like protein GIDA PF01134.22 EXF86465.1 - 0.034 13.2 2.2 0.65 9.0 0.6 2.1 2 0 0 2 2 2 0 Glucose inhibited division protein A Thi4 PF01946.17 EXF86465.1 - 0.07 12.4 0.2 0.13 11.4 0.2 1.4 1 0 0 1 1 1 0 Thi4 family Trp_halogenase PF04820.14 EXF86465.1 - 0.078 11.8 0.8 0.11 11.3 0.8 1.1 1 0 0 1 1 1 0 Tryptophan halogenase FAD_oxidored PF12831.7 EXF86465.1 - 0.4 10.0 3.2 6.5 6.0 2.1 2.3 2 0 0 2 2 2 0 FAD dependent oxidoreductase Pyr_redox PF00070.27 EXF86465.1 - 0.49 11.0 1.7 1 10.0 0.8 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase ADH_zinc_N PF00107.26 EXF86467.1 - 1.1e-21 77.1 0.0 1.6e-21 76.7 0.0 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 EXF86467.1 - 1.2e-18 67.0 0.0 2e-18 66.2 0.0 1.4 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N_2 PF13602.6 EXF86467.1 - 3.2e-06 28.2 0.0 7e-06 27.1 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase DUF2855 PF11017.8 EXF86467.1 - 0.0028 17.5 0.0 0.012 15.4 0.0 1.9 2 1 0 2 2 2 1 Protein of unknown function (DUF2855) Sugar_tr PF00083.24 EXF86468.1 - 3.5e-106 355.8 16.0 4.1e-106 355.5 16.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EXF86468.1 - 2.1e-21 76.3 34.0 2.5e-16 59.6 11.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Glyco_tranf_2_3 PF13641.6 EXF86469.1 - 5.1e-18 65.8 0.1 6.7e-18 65.4 0.1 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 EXF86469.1 - 7.9e-06 25.5 0.2 0.0069 15.9 0.0 2.2 2 0 0 2 2 2 2 Glycosyl transferase family 21 Glycos_transf_2 PF00535.26 EXF86469.1 - 6.8e-05 22.7 0.0 0.00013 21.8 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 2 TRAM1 PF08390.11 EXF86469.1 - 0.38 10.5 2.2 0.9 9.2 2.2 1.6 1 0 0 1 1 1 0 TRAM1-like protein p450 PF00067.22 EXF86471.1 - 1.5e-66 225.0 0.0 1.8e-66 224.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 AA_permease PF00324.21 EXF86472.1 - 2.6e-119 398.9 41.6 3e-119 398.7 41.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EXF86472.1 - 1.8e-36 125.9 48.4 3e-36 125.2 48.4 1.3 1 0 0 1 1 1 1 Amino acid permease Fungal_trans_2 PF11951.8 EXF86473.1 - 2.9e-08 32.9 0.3 6.1e-05 22.0 0.0 2.3 2 0 0 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF86473.1 - 6.9e-06 26.1 5.7 6.9e-06 26.1 5.7 2.1 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain p450 PF00067.22 EXF86474.1 - 7.1e-79 265.7 0.0 9.5e-79 265.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 FAD_binding_1 PF00667.20 EXF86474.1 - 9.9e-30 103.8 0.0 1.7e-29 103.0 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 EXF86474.1 - 6.4e-25 88.0 0.0 1.2e-24 87.1 0.0 1.5 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 EXF86474.1 - 8.8e-10 39.2 0.0 2e-09 38.0 0.0 1.7 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Flavodoxin_5 PF12724.7 EXF86474.1 - 7.2e-05 23.1 0.0 0.00032 20.9 0.0 1.9 2 0 0 2 2 2 1 Flavodoxin domain DnaG_DnaB_bind PF08278.11 EXF86474.1 - 0.017 15.7 0.1 0.076 13.6 0.1 2.1 1 0 0 1 1 1 0 DNA primase DnaG DnaB-binding NAD_binding_10 PF13460.6 EXF86474.1 - 0.12 12.3 0.0 0.27 11.1 0.0 1.6 1 0 0 1 1 1 0 NAD(P)H-binding DcpS PF05652.12 EXF86475.1 - 1.6e-37 128.5 0.0 2.6e-37 127.8 0.0 1.3 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme (DcpS) N-terminal DcpS_C PF11969.8 EXF86475.1 - 1e-31 109.8 0.1 1.6e-31 109.1 0.1 1.3 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding GILT PF03227.16 EXF86476.1 - 1.2e-18 67.3 0.0 2.1e-18 66.5 0.0 1.3 1 0 0 1 1 1 1 Gamma interferon inducible lysosomal thiol reductase (GILT) PSI_8 PF00796.18 EXF86476.1 - 0.53 10.2 3.1 1 9.2 3.1 1.5 1 0 0 1 1 1 0 Photosystem I reaction centre subunit VIII Hexokinase_2 PF03727.16 EXF86477.1 - 5.1e-41 140.7 0.0 7e-41 140.2 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 EXF86477.1 - 2.3e-38 132.1 0.0 3.5e-38 131.5 0.0 1.3 1 0 0 1 1 1 1 Hexokinase SelP_N PF04592.14 EXF86477.1 - 5.1 6.4 10.5 9.2 5.6 10.5 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region BIRC6 PF12356.8 EXF86479.1 - 0.12 11.8 0.1 0.12 11.8 0.1 1.6 2 0 0 2 2 2 0 Baculoviral IAP repeat-containing protein 6 Pyridox_oxase_2 PF12766.7 EXF86480.1 - 4.8e-19 68.8 0.0 7.7e-19 68.2 0.0 1.3 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase CRR7 PF12095.8 EXF86481.1 - 0.11 13.0 0.1 0.18 12.3 0.1 1.3 1 0 0 1 1 1 0 Protein CHLORORESPIRATORY REDUCTION 7 TAFH PF07531.14 EXF86483.1 - 0.16 12.1 0.1 0.55 10.4 0.0 1.9 2 0 0 2 2 2 0 NHR1 homology to TAF Helo_like_N PF17111.5 EXF86484.1 - 0.0026 17.2 0.3 0.024 14.0 0.0 2.4 1 1 1 3 3 3 1 Fungal N-terminal domain of STAND proteins UPF0561 PF10573.9 EXF86484.1 - 0.049 13.8 0.5 0.049 13.8 0.5 2.0 2 0 0 2 2 2 0 Uncharacterised protein family UPF0561 Med9 PF07544.13 EXF86484.1 - 0.51 10.5 2.9 7.5 6.7 0.0 3.0 3 0 0 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 V_ATPase_I PF01496.19 EXF86484.1 - 6.1 4.6 5.7 23 2.8 5.7 1.8 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family Fungal_trans PF04082.18 EXF86486.1 - 1.3e-41 142.4 0.0 2.1e-41 141.7 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF86486.1 - 3.2e-08 33.6 6.7 6.9e-08 32.5 6.7 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain NACHT PF05729.12 EXF86487.1 - 1.7e-06 28.1 0.0 6.6e-06 26.1 0.0 2.0 2 0 0 2 2 2 1 NACHT domain Ank_4 PF13637.6 EXF86487.1 - 2.1e-05 25.0 1.2 0.0016 19.0 0.0 3.3 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EXF86487.1 - 6e-05 23.6 0.0 0.0011 19.5 0.0 3.1 3 1 1 4 4 4 2 Ankyrin repeats (3 copies) DUF2075 PF09848.9 EXF86487.1 - 0.011 15.1 0.0 0.02 14.2 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Helo_like_N PF17111.5 EXF86487.1 - 0.013 14.9 1.0 0.027 13.8 1.0 1.5 1 0 0 1 1 1 0 Fungal N-terminal domain of STAND proteins AAA_22 PF13401.6 EXF86487.1 - 0.028 14.7 0.0 0.15 12.3 0.0 2.3 2 2 0 2 2 2 0 AAA domain AAA_16 PF13191.6 EXF86487.1 - 0.043 14.2 0.0 0.14 12.6 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain RNA_helicase PF00910.22 EXF86487.1 - 0.081 13.3 0.0 0.23 11.8 0.0 1.8 1 0 0 1 1 1 0 RNA helicase Hemerythrin PF01814.23 EXF86487.1 - 0.093 13.3 1.1 1 10.0 0.1 3.1 4 0 0 4 4 4 0 Hemerythrin HHE cation binding domain MobB PF03205.14 EXF86487.1 - 0.11 12.4 0.0 0.27 11.1 0.0 1.7 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B zf-RING_2 PF13639.6 EXF86488.1 - 9.7e-14 51.4 17.5 1.1e-13 51.2 7.6 2.3 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.6 EXF86488.1 - 1.9e-12 46.8 9.0 8.9e-09 35.1 2.8 2.2 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EXF86488.1 - 2.2e-10 40.2 17.5 2.1e-09 37.1 7.1 2.3 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EXF86488.1 - 4e-10 39.3 2.7 4e-10 39.3 2.7 2.9 3 0 0 3 3 3 1 RING-like zinc finger zf-C3HC4 PF00097.25 EXF86488.1 - 1e-08 34.9 14.5 1.3e-06 28.2 5.9 2.3 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EXF86488.1 - 7.3e-07 29.4 6.9 7.3e-07 29.4 6.9 2.4 2 0 0 2 2 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 EXF86488.1 - 9.6e-07 28.7 4.2 9.6e-07 28.7 4.2 2.3 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EXF86488.1 - 9.4e-06 25.6 1.2 9.4e-06 25.6 1.2 2.9 2 1 1 3 3 3 1 RING-type zinc-finger Prok-RING_4 PF14447.6 EXF86488.1 - 1.2e-05 25.1 13.1 8.6e-05 22.3 5.3 2.3 2 0 0 2 2 2 2 Prokaryotic RING finger family 4 HypA PF01155.19 EXF86488.1 - 0.0017 18.3 0.5 0.0017 18.3 0.5 2.1 2 0 0 2 2 2 1 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-ANAPC11 PF12861.7 EXF86488.1 - 0.0026 17.8 3.2 0.0026 17.8 3.2 2.1 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_1 PF14446.6 EXF86488.1 - 0.039 13.9 11.8 0.27 11.2 2.1 3.4 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 zf-C3HC4_4 PF15227.6 EXF86488.1 - 0.093 12.9 14.2 0.49 10.6 2.3 2.9 2 1 1 3 3 3 0 zinc finger of C3HC4-type, RING AAA_7 PF12775.7 EXF86488.1 - 0.17 11.3 0.0 0.29 10.6 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region Baculo_RING PF05883.11 EXF86488.1 - 0.22 11.5 0.7 0.45 10.5 0.7 1.4 1 0 0 1 1 1 0 Baculovirus U-box/Ring-like domain zf-FPG_IleRS PF06827.14 EXF86488.1 - 0.31 11.0 2.9 16 5.5 0.6 2.8 2 0 0 2 2 2 0 Zinc finger found in FPG and IleRS Rad50_zn_hook PF04423.14 EXF86488.1 - 0.47 10.3 1.8 7 6.6 0.1 2.4 2 0 0 2 2 2 0 Rad50 zinc hook motif zf-UDP PF14569.6 EXF86488.1 - 0.5 10.5 4.1 2.4 8.3 1.2 2.4 2 0 0 2 2 2 0 Zinc-binding RING-finger zinc-ribbons_6 PF07191.12 EXF86488.1 - 0.57 10.2 9.4 0.59 10.2 1.1 2.7 2 1 0 2 2 2 0 zinc-ribbons PHD PF00628.29 EXF86488.1 - 0.88 9.5 15.2 3.5 7.6 1.7 2.5 2 0 0 2 2 2 0 PHD-finger zf-RING_4 PF14570.6 EXF86488.1 - 0.98 9.3 15.5 0.26 11.1 5.4 2.3 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain DZR PF12773.7 EXF86488.1 - 0.99 9.5 7.5 2 8.5 0.6 2.5 2 1 0 2 2 2 0 Double zinc ribbon PhnA_Zn_Ribbon PF08274.12 EXF86488.1 - 0.99 9.4 5.0 17 5.5 0.5 2.5 2 0 0 2 2 2 0 PhnA Zinc-Ribbon Zn_ribbon_17 PF17120.5 EXF86488.1 - 5.5 6.7 16.7 6 6.6 6.1 2.4 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type DNA_ligase_ZBD PF03119.16 EXF86488.1 - 7.3 6.7 8.8 4.7 7.3 0.5 3.2 3 0 0 3 3 3 0 NAD-dependent DNA ligase C4 zinc finger domain Fis1_TPR_C PF14853.6 EXF86489.1 - 1.4e-25 89.1 1.0 2.6e-25 88.2 1.0 1.5 1 0 0 1 1 1 1 Fis1 C-terminal tetratricopeptide repeat Fis1_TPR_N PF14852.6 EXF86489.1 - 8.8e-18 63.7 0.1 1.4e-17 63.0 0.1 1.4 1 0 0 1 1 1 1 Fis1 N-terminal tetratricopeptide repeat TPR_2 PF07719.17 EXF86489.1 - 0.0051 16.8 1.4 0.0095 16.0 1.4 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat Spc24 PF08286.11 EXF86490.1 - 1.6e-37 127.9 3.7 9.9e-36 122.2 0.0 2.2 2 0 0 2 2 2 1 Spc24 subunit of Ndc80 Miff PF05644.11 EXF86490.1 - 0.009 15.7 4.1 0.012 15.3 4.1 1.2 1 0 0 1 1 1 1 Mitochondrial and peroxisomal fission factor Mff V_ATPase_I PF01496.19 EXF86490.1 - 0.013 13.5 2.1 0.013 13.5 2.1 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family GTA_holin_3TM PF11351.8 EXF86490.1 - 0.051 14.1 0.7 0.051 14.1 0.7 2.2 1 1 1 2 2 2 0 Holin of 3TMs, for gene-transfer release Abi_C PF14355.6 EXF86490.1 - 0.1 12.7 4.3 0.36 11.0 1.4 2.8 2 2 2 4 4 4 0 Abortive infection C-terminus Nsp1_C PF05064.13 EXF86490.1 - 0.19 11.6 5.5 0.55 10.1 0.5 2.3 1 1 1 2 2 2 0 Nsp1-like C-terminal region XhlA PF10779.9 EXF86490.1 - 0.35 11.1 8.3 0.83 9.9 2.2 2.3 2 0 0 2 2 2 0 Haemolysin XhlA DUF4164 PF13747.6 EXF86490.1 - 0.63 10.3 15.5 21 5.5 14.9 2.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4164) DUF1690 PF07956.11 EXF86490.1 - 0.89 10.0 10.6 4.8 7.6 10.6 1.9 1 1 0 1 1 1 0 Protein of Unknown function (DUF1690) CLZ PF16526.5 EXF86490.1 - 1.2 9.6 9.3 4.9 7.6 1.7 2.9 2 1 1 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF2203 PF09969.9 EXF86490.1 - 1.5 9.6 6.2 1.8 9.3 5.2 1.6 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) DASH_Dam1 PF08653.10 EXF86490.1 - 3.4 7.5 5.2 34 4.3 0.2 3.3 4 0 0 4 4 4 0 DASH complex subunit Dam1 SlyX PF04102.12 EXF86490.1 - 5.8 7.6 9.6 15 6.3 2.0 2.7 1 1 1 2 2 2 0 SlyX GvpG PF05120.12 EXF86490.1 - 6.4 6.9 7.7 0.67 10.0 2.3 2.0 2 1 0 2 2 2 0 Gas vesicle protein G BTB PF00651.31 EXF86492.1 - 2.1e-05 24.7 0.0 7e-05 23.0 0.0 1.8 1 1 0 1 1 1 1 BTB/POZ domain Cyclin PF08613.11 EXF86493.1 - 1.1e-42 146.1 0.0 2.4e-42 145.0 0.0 1.6 1 1 0 1 1 1 1 Cyclin TPP_enzyme_N PF02776.18 EXF86494.1 - 1e-39 135.9 0.0 7.3e-38 129.9 0.0 2.4 2 0 0 2 2 2 2 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 EXF86494.1 - 2.7e-24 85.7 0.0 6.2e-24 84.5 0.0 1.7 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 EXF86494.1 - 3.9e-13 49.3 0.0 1.4e-12 47.5 0.0 1.9 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain DUF4267 PF14087.6 EXF86496.1 - 7.3e-21 74.3 3.3 8.6e-21 74.1 3.3 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4267) Peptidase_S8 PF00082.22 EXF86497.1 - 1.3e-41 142.8 3.6 2e-41 142.2 3.6 1.2 1 0 0 1 1 1 1 Subtilase family fn3_5 PF06280.12 EXF86497.1 - 4.1e-10 40.4 0.5 1e-09 39.1 0.1 1.9 2 0 0 2 2 2 1 Fn3-like domain G5 PF07501.12 EXF86497.1 - 0.18 12.3 0.2 0.45 11.0 0.2 1.6 1 0 0 1 1 1 0 G5 domain zf-RING_2 PF13639.6 EXF86498.1 - 1.9e-06 28.1 7.8 1.9e-06 28.1 7.8 2.5 3 0 0 3 3 3 1 Ring finger domain zf-RING_UBOX PF13445.6 EXF86498.1 - 7.2e-05 22.7 1.3 7.2e-05 22.7 1.3 3.0 1 1 1 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 EXF86498.1 - 0.00025 20.9 5.4 0.00025 20.9 5.4 2.7 3 0 0 3 3 3 1 zinc-RING finger domain zf-C3HC4 PF00097.25 EXF86498.1 - 0.00052 19.8 6.2 0.00052 19.8 6.2 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EXF86498.1 - 0.007 16.2 12.6 0.012 15.5 9.5 2.7 2 1 0 2 2 2 1 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 EXF86498.1 - 0.13 12.6 14.3 0.089 13.1 11.5 2.3 2 0 0 2 2 2 0 RING-H2 zinc finger domain GAGA PF09237.11 EXF86498.1 - 0.15 11.9 2.2 1.6 8.6 0.2 2.6 2 0 0 2 2 2 0 GAGA factor FANCL_C PF11793.8 EXF86498.1 - 3.9 7.7 12.3 0.75 10.0 7.2 2.5 3 1 0 3 3 3 0 FANCL C-terminal domain Glyco_hydro_28 PF00295.17 EXF86499.1 - 4.3e-45 154.2 4.9 6.2e-45 153.7 4.9 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 Phage_holin_2_4 PF16082.5 EXF86500.1 - 0.077 12.7 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Bacteriophage holin family, superfamily II-like zf-RING_5 PF14634.6 EXF86502.1 - 1.1e-06 28.5 5.1 1.1e-06 28.5 5.1 2.2 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EXF86502.1 - 3.5e-05 23.7 3.9 7.9e-05 22.6 3.9 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EXF86502.1 - 0.00042 20.1 7.1 0.00042 20.1 7.1 2.2 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EXF86502.1 - 0.0018 18.5 5.5 0.0018 18.5 5.5 2.4 2 1 1 3 3 3 1 Ring finger domain Prok-RING_4 PF14447.6 EXF86502.1 - 0.0026 17.6 7.3 0.011 15.6 7.2 2.0 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 EXF86502.1 - 0.0054 16.5 1.5 0.0054 16.5 1.5 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EXF86502.1 - 0.008 16.3 2.7 0.008 16.3 2.7 2.6 3 0 0 3 3 3 1 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.7 EXF86502.1 - 0.04 14.2 2.8 0.095 13.0 2.8 1.7 1 0 0 1 1 1 0 RING-H2 zinc finger domain FYVE PF01363.21 EXF86502.1 - 1.3 9.2 9.4 2.8 8.2 9.4 1.6 1 1 0 1 1 1 0 FYVE zinc finger GATase PF00117.28 EXF86503.1 - 2.4e-05 24.2 0.0 3.4e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I ADH_N PF08240.12 EXF86505.1 - 1.7e-17 63.3 4.1 6.3e-17 61.4 0.2 2.8 3 0 0 3 3 3 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EXF86505.1 - 1.7e-17 63.6 0.3 3.1e-17 62.8 0.3 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EXF86505.1 - 2.4e-07 31.9 0.2 1.1e-06 29.8 0.0 2.0 2 0 0 2 2 2 1 Zinc-binding dehydrogenase NAD_binding_2 PF03446.15 EXF86505.1 - 0.0049 17.1 0.1 0.0077 16.4 0.1 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Mur_ligase PF01225.25 EXF86505.1 - 0.037 14.4 0.6 0.069 13.5 0.6 1.5 1 0 0 1 1 1 0 Mur ligase family, catalytic domain 2-Hacid_dh_C PF02826.19 EXF86505.1 - 0.23 10.8 0.4 0.37 10.1 0.4 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ADC PF06314.11 EXF86506.1 - 8.9e-35 120.4 0.0 1e-34 120.1 0.0 1.0 1 0 0 1 1 1 1 Acetoacetate decarboxylase (ADC) Tyrosinase PF00264.20 EXF86508.1 - 1.7e-53 182.2 0.0 2.3e-53 181.7 0.0 1.2 1 0 0 1 1 1 1 Common central domain of tyrosinase Na_Ca_ex PF01699.24 EXF86509.1 - 3.8e-18 65.9 18.8 1.6e-16 60.6 9.7 2.1 2 0 0 2 2 2 2 Sodium/calcium exchanger protein NrsF PF06532.11 EXF86509.1 - 0.42 10.3 8.9 0.051 13.3 3.8 2.0 2 0 0 2 2 2 0 Negative regulator of sigma F EHN PF06441.12 EXF86511.1 - 2.1e-26 92.4 0.8 3.4e-26 91.7 0.8 1.3 1 0 0 1 1 1 1 Epoxide hydrolase N terminus Abhydrolase_1 PF00561.20 EXF86511.1 - 1.4e-06 28.1 0.0 2.7e-06 27.2 0.0 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EXF86511.1 - 0.00013 22.6 1.0 0.00013 22.6 1.0 2.3 2 1 0 2 2 2 1 Alpha/beta hydrolase family SMP_LBD PF17047.5 EXF86512.1 - 5.1e-23 81.5 0.1 7.4e-23 80.9 0.1 1.2 1 0 0 1 1 1 1 Synaptotagmin-like mitochondrial-lipid-binding domain C2 PF00168.30 EXF86512.1 - 9.7e-18 64.4 0.0 2.1e-12 47.3 0.0 2.3 2 0 0 2 2 2 2 C2 domain HET PF06985.11 EXF86513.1 - 5.8e-31 107.8 0.9 1.1e-30 106.9 0.9 1.5 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) p450 PF00067.22 EXF86514.1 - 3e-48 164.8 0.0 4.1e-48 164.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 BolA PF01722.18 EXF86515.1 - 7.5e-11 42.1 0.0 1.7e-10 41.0 0.0 1.6 1 1 0 1 1 1 1 BolA-like protein COesterase PF00135.28 EXF86516.1 - 9e-89 298.7 0.0 2.9e-88 297.0 0.0 1.6 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EXF86516.1 - 7.8e-05 22.6 0.1 0.00023 21.1 0.1 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S8 PF00082.22 EXF86517.1 - 2.4e-42 145.2 0.0 7e-42 143.7 0.0 1.6 1 1 0 1 1 1 1 Subtilase family fn3_5 PF06280.12 EXF86517.1 - 1.4e-19 70.9 0.0 3.4e-19 69.6 0.0 1.7 1 0 0 1 1 1 1 Fn3-like domain PA PF02225.22 EXF86517.1 - 3.5e-08 33.3 0.1 1.3e-07 31.5 0.1 2.0 1 0 0 1 1 1 1 PA domain FlgD_ig PF13860.6 EXF86517.1 - 0.00014 21.6 0.0 0.00093 19.0 0.0 2.5 2 0 0 2 2 2 1 FlgD Ig-like domain DUF1735 PF08522.10 EXF86517.1 - 0.038 14.6 0.3 8.7 7.0 0.0 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1735) RPT PF13446.6 EXF86517.1 - 0.15 12.0 0.0 0.33 10.9 0.0 1.5 1 0 0 1 1 1 0 A repeated domain in UCH-protein MFS_1 PF07690.16 EXF86518.1 - 4.5e-28 98.2 61.8 4e-27 95.1 45.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF1593 PF07632.11 EXF86519.1 - 1.9e-79 266.8 0.0 2.4e-79 266.4 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1593) Tyr-DNA_phospho PF06087.12 EXF86520.1 - 6.5e-81 272.4 0.0 1.3e-40 139.6 0.0 2.0 2 0 0 2 2 2 2 Tyrosyl-DNA phosphodiesterase PLDc_2 PF13091.6 EXF86520.1 - 0.00027 20.9 0.0 0.011 15.6 0.0 2.5 2 0 0 2 2 2 1 PLD-like domain UIM PF02809.20 EXF86520.1 - 0.00076 19.2 0.6 0.0025 17.6 0.6 2.0 1 0 0 1 1 1 1 Ubiquitin interaction motif FAM110_C PF14160.6 EXF86520.1 - 1.8 9.7 0.0 1.8 9.7 0.0 3.6 5 0 0 5 5 5 0 Centrosome-associated C terminus PNRC PF15365.6 EXF86521.1 - 3e-08 33.2 8.4 3e-08 33.2 8.4 4.0 4 0 0 4 4 4 1 Proline-rich nuclear receptor coactivator motif zf-rbx1 PF12678.7 EXF86522.1 - 6.9e-25 87.1 12.9 9.7e-25 86.6 12.9 1.2 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 EXF86522.1 - 4.7e-17 61.8 9.8 6.1e-17 61.5 9.8 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.6 EXF86522.1 - 3.8e-06 27.1 14.1 0.00014 22.1 14.1 2.2 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EXF86522.1 - 5.2e-05 23.0 3.1 5.2e-05 23.0 3.1 2.3 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EXF86522.1 - 0.0016 18.3 11.5 0.028 14.3 11.5 2.4 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EXF86522.1 - 0.19 11.6 10.7 0.6 10.0 4.5 2.6 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EXF86522.1 - 0.34 10.7 15.9 29 4.5 15.9 2.4 1 1 0 1 1 1 0 RING-like zinc finger zf-RING_UBOX PF13445.6 EXF86522.1 - 0.4 10.7 6.8 1.5 9.0 6.8 2.0 1 1 0 1 1 1 0 RING-type zinc-finger FANCL_C PF11793.8 EXF86522.1 - 1 9.6 9.4 5.9 7.2 9.6 2.0 1 1 1 2 2 2 0 FANCL C-terminal domain Zn_ribbon_17 PF17120.5 EXF86522.1 - 1.3 8.7 15.0 0.32 10.6 4.9 2.3 1 1 1 2 2 2 0 Zinc-ribbon, C4HC2 type zf-RING_5 PF14634.6 EXF86522.1 - 6.3 6.8 12.2 55 3.8 12.2 2.5 1 1 0 1 1 1 0 zinc-RING finger domain SPC12 PF06645.13 EXF86523.1 - 3.7e-31 107.0 0.2 4.4e-31 106.8 0.2 1.1 1 0 0 1 1 1 1 Microsomal signal peptidase 12 kDa subunit (SPC12) DUF3040 PF11239.8 EXF86523.1 - 0.079 13.2 0.6 0.11 12.8 0.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) CorA PF01544.18 EXF86524.1 - 6.1e-42 143.9 0.0 8.3e-42 143.5 0.0 1.2 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein zf-Tim10_DDP PF02953.15 EXF86525.1 - 4.5e-23 80.7 0.8 5.6e-23 80.4 0.8 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger Ribosomal_L23eN PF03939.13 EXF86526.1 - 1.2e-24 86.2 6.0 1.2e-24 86.2 6.0 1.9 2 0 0 2 2 2 1 Ribosomal protein L23, N-terminal domain Ribosomal_L23 PF00276.20 EXF86526.1 - 1.4e-15 57.4 0.6 2.5e-15 56.6 0.6 1.5 1 0 0 1 1 1 1 Ribosomal protein L23 Bmt2 PF11968.8 EXF86527.1 - 1e-84 283.8 0.0 1.3e-84 283.5 0.0 1.1 1 0 0 1 1 1 1 25S rRNA (adenine(2142)-N(1))-methyltransferase, Bmt2 Methyltransf_23 PF13489.6 EXF86527.1 - 0.0019 18.0 0.0 0.0027 17.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain HAD_2 PF13419.6 EXF86528.1 - 0.00062 19.9 0.0 0.0009 19.4 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EXF86528.1 - 0.005 17.2 0.0 0.0069 16.7 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Pkinase PF00069.25 EXF86529.1 - 1.2e-56 192.0 0.0 3.1e-56 190.7 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EXF86529.1 - 5.2e-35 121.0 0.0 1.9e-34 119.1 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 EXF86529.1 - 4.6e-13 49.1 0.0 1.6e-10 40.8 0.0 2.2 2 0 0 2 2 2 2 Kinase-like Kdo PF06293.14 EXF86529.1 - 0.023 14.0 0.0 0.047 13.1 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EXF86529.1 - 0.04 12.7 0.1 0.32 9.7 0.0 2.0 2 0 0 2 2 2 0 Fungal protein kinase APH PF01636.23 EXF86529.1 - 0.062 13.2 0.2 0.33 10.9 0.0 2.0 2 0 0 2 2 2 0 Phosphotransferase enzyme family Aa_trans PF01490.18 EXF86530.1 - 9e-59 199.2 32.1 1.1e-58 198.9 32.1 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein SBDS PF01172.18 EXF86531.1 - 6.1e-26 90.3 0.5 7.1e-26 90.1 0.5 1.1 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein RhoGEF PF00621.20 EXF86532.1 - 8.9e-25 88.0 0.0 1.5e-24 87.3 0.0 1.3 1 0 0 1 1 1 1 RhoGEF domain E1-E2_ATPase PF00122.20 EXF86533.1 - 3.2e-52 176.7 4.8 9.6e-52 175.1 1.6 2.6 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 EXF86533.1 - 4.8e-46 156.8 4.2 4.8e-46 156.8 4.2 1.6 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 EXF86533.1 - 3.2e-25 89.7 0.6 3.2e-21 76.6 0.1 2.8 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EXF86533.1 - 1.1e-20 73.5 0.0 2.6e-20 72.3 0.0 1.7 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 EXF86533.1 - 1e-18 66.7 0.0 2.3e-18 65.6 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EXF86533.1 - 5.4e-08 32.9 1.1 3.2e-06 27.1 0.9 2.4 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 EXF86533.1 - 3e-06 27.8 0.0 1.2e-05 25.8 0.0 2.1 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Phage_sheath_1 PF04984.14 EXF86533.1 - 0.22 11.4 1.1 42 3.9 0.1 3.3 2 1 1 3 3 3 0 Phage tail sheath protein subtilisin-like domain Proteasome PF00227.26 EXF86534.1 - 5.4e-37 127.1 0.0 6.1e-37 127.0 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit TUG-UBL1 PF11470.8 EXF86535.1 - 2.8e-25 88.3 0.1 5.5e-25 87.4 0.1 1.5 1 0 0 1 1 1 1 TUG ubiquitin-like domain UBX PF00789.20 EXF86535.1 - 0.00023 21.3 0.0 0.0012 19.0 0.0 2.2 2 0 0 2 2 2 1 UBX domain DUF4294 PF14127.6 EXF86535.1 - 0.0029 17.5 0.0 0.0062 16.5 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4294) RBD PF02196.15 EXF86535.1 - 0.0085 16.1 0.1 0.02 15.0 0.1 1.5 1 0 0 1 1 1 1 Raf-like Ras-binding domain Ribosomal_L36e PF01158.18 EXF86536.1 - 3.6e-41 139.3 7.4 4e-41 139.2 7.4 1.0 1 0 0 1 1 1 1 Ribosomal protein L36e MRP-L28 PF09812.9 EXF86536.1 - 0.046 13.9 1.6 0.054 13.6 1.6 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L28 AltA1 PF16541.5 EXF86537.1 - 0.00069 20.5 0.5 0.0013 19.6 0.3 1.5 1 1 1 2 2 2 1 Alternaria alternata allergen 1 Lipase_3 PF01764.25 EXF86538.1 - 1.8e-31 108.9 0.0 2.5e-31 108.4 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) Thioesterase PF00975.20 EXF86538.1 - 0.00027 21.1 0.0 0.0005 20.2 0.0 1.4 1 0 0 1 1 1 1 Thioesterase domain Abhydrolase_6 PF12697.7 EXF86538.1 - 0.00028 21.5 0.2 0.00063 20.4 0.2 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EXF86538.1 - 0.00059 19.2 0.0 0.00092 18.5 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 DUF2974 PF11187.8 EXF86538.1 - 0.016 14.8 0.0 0.19 11.3 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2974) Abhydrolase_1 PF00561.20 EXF86538.1 - 0.021 14.5 0.0 0.043 13.5 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold PGAP1 PF07819.13 EXF86538.1 - 0.19 11.4 0.0 0.3 10.8 0.0 1.2 1 0 0 1 1 1 0 PGAP1-like protein 14-3-3 PF00244.20 EXF86539.1 - 1.2e-106 355.3 0.2 1.4e-106 355.0 0.2 1.1 1 0 0 1 1 1 1 14-3-3 protein Ribosomal_60s PF00428.19 EXF86539.1 - 0.019 15.5 7.7 0.064 13.8 4.3 2.4 2 0 0 2 2 2 0 60s Acidic ribosomal protein TPR_19 PF14559.6 EXF86539.1 - 0.21 12.1 1.2 3.3 8.3 0.1 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat Syja_N PF02383.18 EXF86541.1 - 1.8e-73 247.7 0.0 3.9e-73 246.6 0.0 1.6 2 0 0 2 2 2 1 SacI homology domain Exo_endo_phos PF03372.23 EXF86541.1 - 3.8e-10 39.7 0.1 7.4e-10 38.7 0.1 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family CBF PF03914.17 EXF86542.1 - 0.055 13.5 0.0 0.1 12.6 0.0 1.4 1 0 0 1 1 1 0 CBF/Mak21 family Suf PF05843.14 EXF86543.1 - 0.00072 19.6 12.8 0.091 12.7 0.0 3.9 2 2 1 3 3 3 3 Suppressor of forked protein (Suf) TPR_14 PF13428.6 EXF86543.1 - 0.0011 19.6 10.2 0.25 12.3 0.0 7.4 8 2 3 11 11 11 1 Tetratricopeptide repeat HTS PF04204.16 EXF86543.1 - 5.3 5.9 10.6 1.1 8.1 3.7 2.2 2 0 0 2 2 2 0 Homoserine O-succinyltransferase peroxidase PF00141.23 EXF86544.1 - 1.1e-47 162.7 0.0 1.8e-47 162.0 0.0 1.3 1 0 0 1 1 1 1 Peroxidase ATP11 PF06644.11 EXF86545.1 - 2.8e-105 352.0 0.4 3.3e-105 351.8 0.4 1.1 1 0 0 1 1 1 1 ATP11 protein CdiI_2 PF18593.1 EXF86545.1 - 0.12 13.1 0.8 0.25 12.0 0.2 1.9 2 0 0 2 2 2 0 CdiI immunity protein AAA PF00004.29 EXF86546.1 - 8.9e-49 165.3 0.0 7.2e-43 146.2 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EXF86546.1 - 0.0001 22.7 0.1 0.022 15.2 0.0 3.1 1 1 0 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 EXF86546.1 - 0.00019 21.2 0.0 0.00061 19.6 0.0 1.8 2 0 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EXF86546.1 - 0.00068 19.9 0.1 0.038 14.3 0.0 2.9 2 1 1 3 3 3 1 AAA domain Parvo_NS1 PF01057.17 EXF86546.1 - 0.0008 18.6 0.0 0.0014 17.8 0.0 1.2 1 0 0 1 1 1 1 Parvovirus non-structural protein NS1 AAA_lid_3 PF17862.1 EXF86546.1 - 0.0031 17.3 5.2 0.25 11.2 0.4 2.9 3 0 0 3 3 3 2 AAA+ lid domain AAA_2 PF07724.14 EXF86546.1 - 0.0039 17.3 0.0 0.0093 16.1 0.0 1.6 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_25 PF13481.6 EXF86546.1 - 0.0045 16.6 0.9 0.02 14.4 0.0 2.5 3 1 0 3 3 3 1 AAA domain IstB_IS21 PF01695.17 EXF86546.1 - 0.0071 16.1 0.0 0.016 14.9 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein TIP49 PF06068.13 EXF86546.1 - 0.013 14.8 0.0 0.021 14.0 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain RNA_helicase PF00910.22 EXF86546.1 - 0.014 15.8 0.0 0.04 14.3 0.0 1.8 1 0 0 1 1 1 0 RNA helicase Mg_chelatase PF01078.21 EXF86546.1 - 0.034 13.5 1.3 0.058 12.8 0.1 1.9 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI ATPase PF06745.13 EXF86546.1 - 0.041 13.2 0.0 0.086 12.2 0.0 1.4 1 0 0 1 1 1 0 KaiC AAA_5 PF07728.14 EXF86546.1 - 0.045 13.8 0.0 0.14 12.2 0.0 1.9 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 EXF86546.1 - 0.053 13.0 0.0 0.1 12.1 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_18 PF13238.6 EXF86546.1 - 0.069 13.7 0.0 0.17 12.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 EXF86546.1 - 0.089 12.2 0.0 0.18 11.2 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein AAA_28 PF13521.6 EXF86546.1 - 0.1 12.8 0.0 0.25 11.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 EXF86546.1 - 0.11 12.2 0.0 1.6 8.4 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain TsaE PF02367.17 EXF86546.1 - 0.12 12.4 0.0 0.25 11.3 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Vps4_C PF09336.10 EXF86546.1 - 0.13 12.3 0.1 7.7 6.6 0.0 3.1 3 0 0 3 3 3 0 Vps4 C terminal oligomerisation domain AAA_33 PF13671.6 EXF86546.1 - 0.14 12.4 0.0 0.4 10.8 0.0 1.8 1 0 0 1 1 1 0 AAA domain Prot_ATP_ID_OB PF16450.5 EXF86546.1 - 0.77 9.8 2.3 1.4 8.9 0.3 2.6 3 0 0 3 3 2 0 Proteasomal ATPase OB C-terminal domain Abhydro_lipase PF04083.16 EXF86547.1 - 5e-19 67.6 0.0 1e-18 66.6 0.0 1.6 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Abhydrolase_1 PF00561.20 EXF86547.1 - 4e-06 26.7 0.0 1.1e-05 25.2 0.0 1.7 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EXF86547.1 - 0.0056 16.0 0.0 0.028 13.7 0.0 2.0 2 0 0 2 2 2 1 Serine aminopeptidase, S33 SH3BGR PF04908.15 EXF86548.1 - 0.00049 20.2 0.4 0.003 17.7 0.0 2.6 2 1 1 3 3 3 1 SH3-binding, glutamic acid-rich protein TFIIA PF03153.13 EXF86548.1 - 0.6 10.0 45.8 1.1 9.2 45.8 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Corona_nucleoca PF00937.18 EXF86549.1 - 2.8 6.9 10.4 3.7 6.5 10.4 1.2 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein MAGE PF01454.19 EXF86549.1 - 5.4 6.7 6.4 18 5.0 6.4 1.7 1 1 0 1 1 1 0 MAGE family Apt1 PF10351.9 EXF86549.1 - 9.8 4.9 7.9 10 4.8 7.9 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain DSPn PF14671.6 EXF86550.1 - 1.3e-41 142.4 0.0 2.8e-39 134.8 0.0 2.7 2 1 0 2 2 2 2 Dual specificity protein phosphatase, N-terminal half DSPc PF00782.20 EXF86550.1 - 4.8e-16 58.8 0.0 1e-15 57.7 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EXF86550.1 - 4.3e-06 26.5 0.0 9.3e-06 25.4 0.0 1.5 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Pcc1 PF09341.10 EXF86551.1 - 3.4e-32 110.4 0.6 4.6e-32 110.0 0.6 1.2 1 0 0 1 1 1 1 Transcription factor Pcc1 HLH PF00010.26 EXF86552.1 - 4.7e-15 55.3 1.4 1.3e-14 53.9 1.4 1.8 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Velvet PF11754.8 EXF86553.1 - 6.4e-91 304.7 3.7 1.4e-90 303.6 3.7 1.5 1 1 0 1 1 1 1 Velvet factor RhoGEF PF00621.20 EXF86554.1 - 2.2e-31 109.5 0.0 5e-31 108.3 0.0 1.6 1 0 0 1 1 1 1 RhoGEF domain BAR PF03114.18 EXF86554.1 - 3.6e-10 39.9 0.0 1e-09 38.4 0.0 1.8 1 0 0 1 1 1 1 BAR domain LPD13 PF18825.1 EXF86554.1 - 0.067 12.9 0.0 0.17 11.6 0.0 1.6 1 0 0 1 1 1 0 Large polyvalent protein-associated domain 13 Seryl_tRNA_N PF02403.22 EXF86554.1 - 0.58 10.4 3.4 25 5.1 0.4 2.6 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Telomerase_RBD PF12009.8 EXF86555.1 - 1.4e-50 170.8 0.0 3e-50 169.8 0.0 1.6 1 0 0 1 1 1 1 Telomerase ribonucleoprotein complex - RNA binding domain RVT_1 PF00078.27 EXF86555.1 - 1.9e-11 43.9 0.0 3.8e-08 33.1 0.0 2.6 2 0 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) F-box_5 PF18511.1 EXF86555.1 - 0.066 12.8 0.2 0.21 11.2 0.0 1.9 2 0 0 2 2 2 0 F-box MBOAT_2 PF13813.6 EXF86556.1 - 1.7e-15 57.1 7.8 2.4e-15 56.6 5.5 2.3 2 0 0 2 2 2 1 Membrane bound O-acyl transferase family PAXIP1_C PF15364.6 EXF86558.1 - 0.21 11.9 7.7 0.028 14.7 2.3 2.3 2 0 0 2 2 2 0 PAXIP1-associated-protein-1 C term PTIP binding protein zf-B_box PF00643.24 EXF86558.1 - 0.58 10.4 6.8 1.1 9.4 6.8 1.4 1 0 0 1 1 1 0 B-box zinc finger DUF572 PF04502.13 EXF86558.1 - 0.99 9.0 19.8 0.45 10.1 4.4 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF572) Myb_DNA-bind_6 PF13921.6 EXF86559.1 - 0.00059 20.0 0.2 0.00099 19.3 0.2 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain WW PF00397.26 EXF86560.1 - 4.1e-10 39.6 3.7 8.8e-10 38.5 3.7 1.6 1 0 0 1 1 1 1 WW domain DUF2076 PF09849.9 EXF86560.1 - 0.00084 19.5 26.2 0.00084 19.5 26.2 2.6 1 1 1 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2076) TPR_2 PF07719.17 EXF86560.1 - 1.6 9.1 5.2 5.8 7.3 0.7 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_10 PF13374.6 EXF86560.1 - 1.7 8.6 6.7 2 8.4 1.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat CYSTM PF12734.7 EXF86561.1 - 1.9e-05 24.9 64.5 0.00055 20.2 45.6 4.1 1 1 1 2 2 2 1 Cysteine-rich TM module stress tolerance EF-hand_1 PF00036.32 EXF86562.1 - 1.8e-29 99.0 0.5 7.2e-08 31.4 0.0 4.2 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 EXF86562.1 - 4.1e-25 87.4 0.7 6.7e-11 41.9 0.0 3.0 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_7 PF13499.6 EXF86562.1 - 3.5e-23 81.8 0.1 5.5e-13 49.2 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EXF86562.1 - 1.1e-20 71.7 0.0 4.7e-07 29.2 0.0 4.2 4 0 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.6 EXF86562.1 - 2.3e-18 64.8 1.9 2e-06 27.0 0.0 4.2 4 0 0 4 4 4 3 EF hand EF-hand_9 PF14658.6 EXF86562.1 - 6.5e-11 42.4 0.0 4.8e-05 23.6 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 EXF86562.1 - 2.8e-05 24.0 0.8 0.072 13.0 0.0 2.8 2 1 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 EXF86562.1 - 7e-05 23.1 0.0 0.005 17.2 0.0 2.1 1 1 1 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region SurA_N_3 PF13624.6 EXF86562.1 - 0.0013 18.6 0.1 1.5 8.6 0.0 2.1 1 1 0 2 2 2 2 SurA N-terminal domain EF-hand_11 PF08976.11 EXF86562.1 - 0.0024 18.7 0.0 0.1 13.5 0.0 2.0 1 1 1 2 2 2 1 EF-hand domain DUF5580 PF17743.1 EXF86562.1 - 0.0038 15.8 0.0 0.0042 15.7 0.0 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5580) Dockerin_1 PF00404.18 EXF86562.1 - 0.0045 17.1 0.1 1.5 9.1 0.1 2.4 2 1 0 2 2 2 1 Dockerin type I domain SurA_N_2 PF13623.6 EXF86562.1 - 0.022 14.6 0.4 1.4 8.8 0.1 2.3 1 1 1 2 2 2 0 SurA N-terminal domain UPF0154 PF03672.13 EXF86562.1 - 0.05 13.6 0.0 13 5.9 0.0 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0154) EF-hand_14 PF17959.1 EXF86562.1 - 0.13 12.6 0.0 0.33 11.3 0.0 1.7 2 0 0 2 2 2 0 EF-hand domain EFhand_Ca_insen PF08726.10 EXF86562.1 - 0.13 12.3 0.0 0.51 10.5 0.0 2.0 2 1 0 2 2 2 0 Ca2+ insensitive EF hand Peptidase_C14 PF00656.22 EXF86563.1 - 2.5e-60 204.5 0.0 3.1e-60 204.2 0.0 1.1 1 0 0 1 1 1 1 Caspase domain DUF2249 PF10006.9 EXF86564.1 - 0.11 12.4 0.0 0.34 10.8 0.0 1.8 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2249) Ferric_reduct PF01794.19 EXF86565.1 - 0.0008 19.5 0.3 0.0014 18.8 0.3 1.4 1 1 0 1 1 1 1 Ferric reductase like transmembrane component DUF805 PF05656.14 EXF86565.1 - 0.053 13.9 0.8 0.097 13.1 0.8 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF805) HrpB_C PF08482.10 EXF86565.1 - 0.061 13.7 0.0 0.085 13.3 0.0 1.2 1 0 0 1 1 1 0 ATP-dependent helicase C-terminal DUF3285 PF11688.8 EXF86565.1 - 0.091 12.7 0.1 0.22 11.4 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3285) HisG PF01634.18 EXF86566.1 - 2e-55 187.1 0.1 3.1e-55 186.5 0.1 1.3 1 0 0 1 1 1 1 ATP phosphoribosyltransferase HisG_C PF08029.11 EXF86566.1 - 3.6e-28 97.5 0.1 1.5e-27 95.5 0.1 2.0 2 0 0 2 2 2 1 HisG, C-terminal domain MFS_2 PF13347.6 EXF86567.1 - 1e-12 47.4 11.6 1e-12 47.4 11.6 2.8 3 0 0 3 3 3 1 MFS/sugar transport protein PUCC PF03209.15 EXF86567.1 - 1.2e-05 24.6 3.7 2.6e-05 23.4 3.7 1.5 1 0 0 1 1 1 1 PUCC protein MFS_1_like PF12832.7 EXF86567.1 - 0.00011 21.3 5.0 0.00011 21.3 5.0 1.8 2 0 0 2 2 2 1 MFS_1 like family DUF2070 PF09843.9 EXF86567.1 - 0.18 10.1 3.4 8.8 4.5 2.5 3.0 2 2 0 2 2 2 0 Predicted membrane protein (DUF2070) Pkr1 PF08636.10 EXF86568.1 - 5.5e-30 103.3 6.6 7.1e-30 103.0 6.6 1.1 1 0 0 1 1 1 1 ER protein Pkr1 TraT PF05818.12 EXF86568.1 - 6.1 6.5 8.9 12 5.5 8.9 1.5 1 1 0 1 1 1 0 Enterobacterial TraT complement resistance protein CbiJ PF02571.14 EXF86569.1 - 0.08 12.4 0.1 5.7 6.3 0.1 2.2 2 0 0 2 2 2 0 Precorrin-6x reductase CbiJ/CobK Glyco_hydro_3_C PF01915.22 EXF86571.1 - 3.5e-40 138.1 0.0 5.5e-40 137.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 EXF86571.1 - 1.1e-28 100.6 0.0 1.7e-28 99.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 EXF86571.1 - 2.3e-07 30.8 0.0 5.1e-07 29.7 0.0 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain ACC_epsilon PF13822.6 EXF86572.1 - 2.2 9.0 5.7 3.5 8.4 5.7 1.3 1 0 0 1 1 1 0 Acyl-CoA carboxylase epsilon subunit RCC1 PF00415.18 EXF86573.1 - 8.6e-51 170.4 12.1 1.6e-10 41.5 0.3 8.6 8 1 0 8 8 8 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EXF86573.1 - 5.2e-31 105.8 39.0 3.3e-08 33.1 0.9 6.7 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat Fungal_trans_2 PF11951.8 EXF86574.1 - 5.5e-31 107.7 1.2 6.7e-31 107.5 1.2 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF86574.1 - 8.8e-06 25.7 8.3 1.5e-05 25.0 8.3 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.16 EXF86575.1 - 5e-42 144.1 52.3 5.9e-39 134.0 53.6 2.6 2 1 0 2 2 2 2 Major Facilitator Superfamily DUF1418 PF07214.12 EXF86575.1 - 0.093 12.6 0.1 1.3 9.0 0.0 2.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1418) Pec_lyase_C PF00544.19 EXF86576.1 - 1.3e-43 149.0 8.3 1.9e-43 148.5 8.3 1.2 1 0 0 1 1 1 1 Pectate lyase Beta_helix PF13229.6 EXF86576.1 - 0.0003 20.7 12.1 0.0018 18.2 11.3 2.2 1 1 0 1 1 1 1 Right handed beta helix region Peptidase_M4_C PF02868.15 EXF86577.1 - 1.4e-46 158.4 0.0 4.3e-46 156.8 0.0 1.8 2 0 0 2 2 2 1 Thermolysin metallopeptidase, alpha-helical domain Peptidase_M4 PF01447.18 EXF86577.1 - 3.8e-28 98.8 1.2 5.8e-28 98.2 1.2 1.3 1 0 0 1 1 1 1 Thermolysin metallopeptidase, catalytic domain PLN_propep PF16485.5 EXF86577.1 - 5.3e-21 74.0 1.9 5.4e-13 48.4 0.7 2.4 2 0 0 2 2 2 2 Protealysin propeptide Senescence PF06911.12 EXF86577.1 - 0.016 15.5 0.1 0.074 13.4 0.0 2.1 3 0 0 3 3 3 0 Senescence-associated protein Spermine_synth PF01564.17 EXF86577.1 - 0.042 13.3 0.0 0.12 11.7 0.0 1.7 1 1 1 2 2 2 0 Spermine/spermidine synthase domain Phage_TAC_12 PF12363.8 EXF86577.1 - 0.07 13.5 0.2 0.15 12.5 0.2 1.6 1 0 0 1 1 1 0 Phage tail assembly chaperone protein, TAC Cecropin PF00272.19 EXF86577.1 - 0.12 12.2 0.1 3.8 7.3 0.2 2.8 2 0 0 2 2 2 0 Cecropin family Sec63 PF02889.16 EXF86578.1 - 2.9e-07 29.9 0.0 3.6e-07 29.6 0.0 1.1 1 0 0 1 1 1 1 Sec63 Brl domain FAF PF11250.8 EXF86579.1 - 0.049 13.9 0.0 0.17 12.1 0.0 1.9 2 0 0 2 2 2 0 Fantastic Four meristem regulator Nuc_sug_transp PF04142.15 EXF86580.1 - 1.6e-104 349.5 8.5 2.3e-104 348.9 8.5 1.2 1 0 0 1 1 1 1 Nucleotide-sugar transporter UAA PF08449.11 EXF86580.1 - 7e-08 32.0 6.8 3e-05 23.4 2.5 2.2 2 0 0 2 2 2 2 UAA transporter family EamA PF00892.20 EXF86580.1 - 6.4e-07 29.6 26.1 0.0008 19.6 4.3 2.5 2 0 0 2 2 2 2 EamA-like transporter family TPT PF03151.16 EXF86580.1 - 0.00092 18.6 14.1 0.032 13.6 5.9 2.3 2 0 0 2 2 2 2 Triose-phosphate Transporter family DUF2306 PF10067.9 EXF86580.1 - 0.19 11.9 5.4 0.56 10.4 5.4 1.8 1 0 0 1 1 1 0 Predicted membrane protein (DUF2306) DMT_6 PF04342.12 EXF86580.1 - 1.1 9.5 8.7 5.8 7.2 1.4 2.7 3 0 0 3 3 3 0 Putative member of DMT superfamily (DUF486) TMEM234 PF10639.9 EXF86580.1 - 7.4 6.6 9.2 2.2 8.4 1.2 2.4 2 0 0 2 2 2 0 Putative transmembrane family 234 FAD_binding_4 PF01565.23 EXF86581.1 - 7.5e-24 84.0 0.1 1.3e-23 83.2 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EXF86581.1 - 0.0061 16.6 0.1 0.0061 16.6 0.1 2.6 3 0 0 3 3 3 1 Berberine and berberine like DUF2427 PF10348.9 EXF86582.1 - 0.0017 18.1 0.5 0.0058 16.4 0.5 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF2427) DUF3425 PF11905.8 EXF86583.1 - 4.9e-06 26.5 1.0 9.5e-06 25.6 1.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) DUF3585 PF12130.8 EXF86583.1 - 0.021 14.9 2.2 0.046 13.9 2.2 1.5 1 0 0 1 1 1 0 Bivalent Mical/EHBP Rab binding domain Goodbye PF17109.5 EXF86583.1 - 0.032 14.7 0.3 0.057 13.9 0.3 1.3 1 0 0 1 1 1 0 fungal STAND N-terminal Goodbye domain DUF3399 PF11879.8 EXF86583.1 - 0.044 14.1 0.5 0.044 14.1 0.5 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF3399) DUF1690 PF07956.11 EXF86583.1 - 0.054 13.9 4.5 0.096 13.1 4.5 1.3 1 0 0 1 1 1 0 Protein of Unknown function (DUF1690) DUF2730 PF10805.8 EXF86583.1 - 0.065 13.3 2.8 0.12 12.5 2.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2730) bZIP_1 PF00170.21 EXF86583.1 - 0.12 12.5 9.6 0.28 11.3 9.6 1.6 1 0 0 1 1 1 0 bZIP transcription factor GED PF02212.18 EXF86583.1 - 0.25 11.5 1.3 0.57 10.4 1.3 1.5 1 0 0 1 1 1 0 Dynamin GTPase effector domain MREG PF15812.5 EXF86583.1 - 0.28 11.5 4.1 0.5 10.7 4.1 1.3 1 0 0 1 1 1 0 Melanoregulin SpecificRecomb PF10136.9 EXF86583.1 - 0.33 9.2 1.0 0.47 8.7 1.0 1.1 1 0 0 1 1 1 0 Site-specific recombinase ABC_tran_Xtn PF12848.7 EXF86583.1 - 0.5 10.4 5.3 0.87 9.7 5.3 1.3 1 0 0 1 1 1 0 ABC transporter GATA PF00320.27 EXF86583.1 - 0.74 9.5 6.5 5.7 6.6 0.1 2.5 2 0 0 2 2 2 0 GATA zinc finger DUF4334 PF14232.6 EXF86584.1 - 6e-29 99.8 1.1 1.5e-28 98.5 0.7 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4334) GXWXG PF14231.6 EXF86584.1 - 9.2e-24 83.3 0.1 1.6e-23 82.5 0.1 1.4 1 0 0 1 1 1 1 GXWXG protein FAD_binding_4 PF01565.23 EXF86584.1 - 4.8e-14 52.3 0.0 7.9e-14 51.6 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain Ndc80_HEC PF03801.13 EXF86584.1 - 0.069 12.8 0.0 0.17 11.5 0.0 1.6 1 0 0 1 1 1 0 HEC/Ndc80p family adh_short_C2 PF13561.6 EXF86585.1 - 1.8e-31 109.5 0.7 2.4e-31 109.1 0.7 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EXF86585.1 - 1.2e-26 93.4 0.0 1.7e-26 92.9 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EXF86585.1 - 6.5e-07 29.4 0.1 1e-06 28.8 0.1 1.3 1 0 0 1 1 1 1 KR domain THF_DHG_CYH_C PF02882.19 EXF86585.1 - 0.023 14.0 0.0 0.059 12.7 0.0 1.7 2 0 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain DUF3669 PF12417.8 EXF86586.1 - 1.1e-26 92.8 0.3 2.4e-26 91.7 0.1 1.7 2 0 0 2 2 2 1 Zinc finger protein Complex1_LYR PF05347.15 EXF86587.1 - 2.7e-05 24.1 0.0 0.00014 21.9 0.0 2.3 1 0 0 1 1 1 1 Complex 1 protein (LYR family) bZIP_1 PF00170.21 EXF86588.1 - 5.5e-07 29.6 4.9 1.3e-06 28.4 4.9 1.5 1 0 0 1 1 1 1 bZIP transcription factor bZIP_Maf PF03131.17 EXF86588.1 - 0.5 10.9 9.6 0.66 10.5 7.7 2.2 1 1 0 1 1 1 0 bZIP Maf transcription factor UPF0242 PF06785.11 EXF86588.1 - 5 7.2 6.8 10 6.2 6.8 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF4185 PF13810.6 EXF86589.1 - 1e-14 54.5 0.9 2e-14 53.6 0.9 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4185) Glyco_hydro_43 PF04616.14 EXF86589.1 - 0.00043 19.7 0.2 0.012 15.0 0.0 2.2 1 1 1 2 2 2 2 Glycosyl hydrolases family 43 PI-PLC-C1 PF16670.5 EXF86590.1 - 2e-131 438.0 0.0 2.3e-131 437.8 0.0 1.0 1 0 0 1 1 1 1 Phosphoinositide phospholipase C, Ca2+-dependent IBR PF01485.21 EXF86591.1 - 0.0013 18.9 7.0 0.0013 18.9 7.0 6.0 3 2 2 5 5 5 2 IBR domain, a half RING-finger domain DUF2264 PF10022.9 EXF86592.1 - 2e-131 438.3 1.1 2.8e-131 437.8 1.1 1.2 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2264) Zn_clus PF00172.18 EXF86593.1 - 5.8e-08 32.7 9.9 1e-07 31.9 9.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EXF86593.1 - 9.9e-05 21.3 5.4 9.9e-05 21.3 5.4 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain RTA1 PF04479.13 EXF86594.1 - 2.1e-72 243.0 5.8 3.3e-72 242.4 5.8 1.3 1 0 0 1 1 1 1 RTA1 like protein DctQ PF04290.12 EXF86594.1 - 0.013 15.5 0.6 0.013 15.5 0.6 2.4 3 1 0 3 3 3 0 Tripartite ATP-independent periplasmic transporters, DctQ component Cpta_toxin PF07254.12 EXF86594.1 - 0.043 13.8 0.4 2.7 8.0 0.0 2.7 2 1 1 3 3 3 0 Membrane-bound toxin component of toxin-antitoxin system DUF3989 PF13150.6 EXF86594.1 - 0.22 11.3 0.2 0.22 11.3 0.2 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3989) Phage_holin_3_6 PF07332.11 EXF86594.1 - 4.6 7.3 6.2 0.29 11.2 0.4 2.1 2 1 1 3 3 3 0 Putative Actinobacterial Holin-X, holin superfamily III DUF3176 PF11374.8 EXF86595.1 - 4e-29 101.0 1.8 1.1e-28 99.5 1.8 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF3176) NiFe_hyd_3_EhaA PF17367.2 EXF86595.1 - 0.094 12.9 1.0 0.26 11.4 1.0 1.7 1 0 0 1 1 1 0 NiFe-hydrogenase-type-3 Eha complex subunit A Goodbye PF17109.5 EXF86596.1 - 1.8e-23 83.3 0.0 6.4e-23 81.5 0.0 2.1 1 0 0 1 1 1 1 fungal STAND N-terminal Goodbye domain Peptidase_M36 PF02128.15 EXF86597.1 - 1.5e-161 537.7 2.6 2e-161 537.3 2.6 1.1 1 0 0 1 1 1 1 Fungalysin metallopeptidase (M36) FTP PF07504.13 EXF86597.1 - 1.8e-17 62.9 5.6 1.8e-17 62.9 5.6 2.3 3 0 0 3 3 3 1 Fungalysin/Thermolysin Propeptide Motif Peptidase_M4_C PF02868.15 EXF86597.1 - 0.022 14.6 0.0 0.048 13.5 0.0 1.6 1 0 0 1 1 1 0 Thermolysin metallopeptidase, alpha-helical domain AMP-binding PF00501.28 EXF86598.1 - 8.2e-226 749.5 0.0 1e-76 258.3 0.0 3.4 3 0 0 3 3 3 3 AMP-binding enzyme Condensation PF00668.20 EXF86598.1 - 5.1e-183 608.9 0.1 1.6e-34 119.4 0.4 6.9 6 1 0 6 6 6 6 Condensation domain PP-binding PF00550.25 EXF86598.1 - 5.2e-59 196.5 16.3 7.2e-11 42.3 0.1 7.0 6 0 0 6 6 6 6 Phosphopantetheine attachment site AMP-binding_C PF13193.6 EXF86598.1 - 2.3e-11 44.5 0.0 0.012 16.5 0.0 4.3 4 0 0 4 4 4 3 AMP-binding enzyme C-terminal domain Transferase PF02458.15 EXF86598.1 - 2.6e-07 29.7 0.0 0.088 11.4 0.0 5.4 6 0 0 6 6 6 2 Transferase family WES_acyltransf PF03007.16 EXF86598.1 - 3.3e-07 30.3 0.2 0.15 11.8 0.0 5.5 6 0 0 6 6 6 2 Wax ester synthase-like Acyl-CoA acyltransferase domain K_oxygenase PF13434.6 EXF86600.1 - 3.6e-109 365.0 0.0 9.6e-109 363.6 0.0 1.6 1 1 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.6 EXF86600.1 - 5.4e-07 29.2 0.0 3.7e-06 26.4 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EXF86600.1 - 2.5e-06 27.0 0.0 5.4e-05 22.6 0.0 2.3 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EXF86600.1 - 3.9e-06 26.9 0.1 0.0069 16.4 0.0 2.6 2 1 0 2 2 2 2 FAD-NAD(P)-binding Fungal_trans PF04082.18 EXF86601.1 - 1.7e-14 53.5 0.0 3.3e-14 52.6 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EXF86601.1 - 2.2e-06 27.7 11.4 3.9e-06 26.9 11.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain IF-2B PF01008.17 EXF86602.1 - 2.9e-22 79.2 0.0 4e-22 78.8 0.0 1.2 1 0 0 1 1 1 1 Initiation factor 2 subunit family NUDIX PF00293.28 EXF86602.1 - 2.3e-12 47.1 0.1 5.6e-12 45.8 0.1 1.6 1 0 0 1 1 1 1 NUDIX domain Pterin_4a PF01329.19 EXF86602.1 - 0.019 15.1 0.0 0.077 13.2 0.0 2.0 1 0 0 1 1 1 0 Pterin 4 alpha carbinolamine dehydratase Aminotran_5 PF00266.19 EXF86602.1 - 0.13 11.2 0.2 0.25 10.2 0.2 1.4 1 0 0 1 1 1 0 Aminotransferase class-V MFS_1 PF07690.16 EXF86603.1 - 5.6e-30 104.4 22.1 5.6e-30 104.4 22.1 1.7 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF4064 PF13273.6 EXF86603.1 - 0.49 10.7 4.1 1.9 8.8 1.9 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF4064) CD20 PF04103.15 EXF86603.1 - 6.3 6.9 9.2 0.34 11.0 1.5 2.5 2 0 0 2 2 2 0 CD20-like family DUF4079 PF13301.6 EXF86604.1 - 0.0027 17.9 4.8 0.0027 17.9 4.8 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF4079) Saf_2TM PF18303.1 EXF86604.1 - 0.012 15.2 0.1 0.012 15.2 0.1 2.6 1 1 2 3 3 3 0 SAVED-fused 2TM effector domain DUF3948 PF13134.6 EXF86604.1 - 0.32 10.7 1.9 0.62 9.8 1.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3948) FF PF01846.19 EXF86605.1 - 2.7e-10 40.3 6.1 2.6e-09 37.1 0.5 2.9 3 0 0 3 3 3 2 FF domain WW PF00397.26 EXF86605.1 - 1.9e-08 34.3 2.1 1.9e-08 34.3 2.1 2.9 3 0 0 3 3 3 1 WW domain DUF5641 PF18701.1 EXF86605.1 - 1.2 9.3 4.6 0.8 9.9 1.7 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5641) PAP2 PF01569.21 EXF86606.1 - 4.6e-27 94.5 1.0 4.6e-27 94.5 1.0 2.1 2 0 0 2 2 2 1 PAP2 superfamily TM140 PF14985.6 EXF86606.1 - 0.032 13.8 0.2 0.095 12.2 0.0 1.8 2 0 0 2 2 2 0 TM140 protein family PAP2_3 PF14378.6 EXF86606.1 - 2.1 8.0 10.5 20 4.8 9.4 2.7 1 1 0 1 1 1 0 PAP2 superfamily RIBIOP_C PF04950.12 EXF86607.1 - 8.9e-109 363.4 0.0 1.3e-108 362.9 0.0 1.2 1 0 0 1 1 1 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 EXF86607.1 - 4.8e-18 65.0 0.0 1.1e-17 63.9 0.0 1.7 1 0 0 1 1 1 1 AARP2CN (NUC121) domain cobW PF02492.19 EXF86608.1 - 4.6e-34 117.5 0.0 5.9e-34 117.2 0.0 1.1 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain MeaB PF03308.16 EXF86608.1 - 0.00015 20.8 0.6 0.0012 17.9 0.6 1.9 1 1 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_23 PF13476.6 EXF86608.1 - 0.0028 18.2 0.0 0.0038 17.7 0.0 1.2 1 0 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 EXF86608.1 - 0.0034 17.4 0.0 0.013 15.6 0.0 2.1 2 1 0 2 2 2 1 50S ribosome-binding GTPase ResIII PF04851.15 EXF86608.1 - 0.082 12.9 0.0 0.13 12.3 0.0 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_11 PF13086.6 EXF86608.1 - 0.1 12.3 0.0 14 5.3 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 EXF86608.1 - 0.12 12.8 0.0 0.16 12.3 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain NACHT PF05729.12 EXF86608.1 - 0.2 11.5 0.0 0.3 11.0 0.0 1.3 1 0 0 1 1 1 0 NACHT domain PPI_Ypi1 PF07491.11 EXF86609.1 - 6.3e-25 86.8 3.3 2.9e-24 84.7 3.3 2.2 1 1 0 1 1 1 1 Protein phosphatase inhibitor CDC45 PF02724.14 EXF86609.1 - 1.6 6.9 7.5 1.8 6.8 7.5 1.1 1 0 0 1 1 1 0 CDC45-like protein MMR_HSR1 PF01926.23 EXF86610.1 - 0.00018 21.6 0.0 1.2 9.3 0.0 2.9 3 0 0 3 3 3 2 50S ribosome-binding GTPase L51_S25_CI-B8 PF05047.16 EXF86611.1 - 4.7e-17 61.6 0.1 7.5e-17 61.0 0.1 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain HECT PF00632.25 EXF86612.1 - 1.9e-77 260.8 0.0 2.5e-77 260.4 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) DUF3712 PF12505.8 EXF86613.1 - 2.6e-12 47.1 0.0 7.3e-12 45.7 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF3712) ADH_N PF08240.12 EXF86614.1 - 1.2e-25 89.5 2.2 2.9e-25 88.3 0.9 2.1 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EXF86614.1 - 9.4e-15 54.7 0.0 1.5e-14 54.1 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EXF86614.1 - 1.2e-10 41.2 0.0 1.9e-10 40.6 0.0 1.2 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 EXF86614.1 - 5.7e-09 37.1 0.0 9.9e-09 36.3 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase FAD_binding_3 PF01494.19 EXF86614.1 - 0.02 14.1 0.1 0.032 13.5 0.1 1.2 1 0 0 1 1 1 0 FAD binding domain fn3 PF00041.21 EXF86614.1 - 0.042 14.2 0.0 5.6 7.4 0.0 2.3 2 0 0 2 2 2 0 Fibronectin type III domain Staph_opine_DH PF10100.9 EXF86614.1 - 0.15 10.6 0.0 0.21 10.2 0.0 1.2 1 0 0 1 1 1 0 Staphylopine dehydrogenase S10_plectin PF03501.15 EXF86615.1 - 1.6e-42 143.4 0.1 2e-42 143.2 0.1 1.1 1 0 0 1 1 1 1 Plectin/S10 domain Sde2_N_Ubi PF13019.6 EXF86616.1 - 4.2e-70 234.8 0.8 6.3e-70 234.3 0.8 1.3 1 0 0 1 1 1 1 Silencing defective 2 N-terminal ubiquitin domain COX6B PF02297.17 EXF86617.1 - 6.2e-18 64.8 4.4 7e-18 64.6 4.4 1.1 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb CX9C PF16860.5 EXF86617.1 - 0.017 15.1 2.4 0.026 14.5 2.4 1.3 1 0 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, APOBEC_C PF05240.14 EXF86617.1 - 0.12 12.3 2.3 0.13 12.2 1.4 1.5 1 1 0 1 1 1 0 APOBEC-like C-terminal domain B12D PF06522.11 EXF86618.1 - 5.9e-06 26.0 0.0 7.8e-06 25.6 0.0 1.2 1 0 0 1 1 1 1 NADH-ubiquinone reductase complex 1 MLRQ subunit RRM_1 PF00076.22 EXF86619.1 - 6.6e-18 64.3 0.0 9.6e-18 63.8 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EXF86619.1 - 1.3e-05 25.2 0.0 1.8e-05 24.8 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif Nup35_RRM_2 PF14605.6 EXF86619.1 - 0.042 13.9 0.0 0.069 13.2 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif RRM_5 PF13893.6 EXF86619.1 - 0.077 12.6 0.0 0.16 11.6 0.0 1.4 1 1 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 EXF86619.1 - 0.13 12.4 0.0 0.23 11.6 0.0 1.4 1 0 0 1 1 1 0 Limkain b1 RRM_occluded PF16842.5 EXF86619.1 - 0.15 11.9 0.0 0.45 10.4 0.0 1.9 1 1 0 1 1 1 0 Occluded RNA-recognition motif Sec16_C PF12931.7 EXF86620.1 - 1.8e-11 44.3 0.8 4.8e-10 39.6 0.8 2.4 1 1 0 1 1 1 1 Sec23-binding domain of Sec16 SRA1 PF07304.11 EXF86620.1 - 8.3e-11 41.9 0.0 8.3e-11 41.9 0.0 4.2 3 1 1 4 4 4 1 Steroid receptor RNA activator (SRA1) WD40 PF00400.32 EXF86620.1 - 7.1e-05 23.5 4.6 0.017 16.0 0.0 4.9 6 0 0 6 6 6 1 WD domain, G-beta repeat Prp18 PF02840.15 EXF86620.1 - 0.017 15.1 0.2 0.05 13.7 0.2 1.8 1 1 0 1 1 1 0 Prp18 domain PALB2_WD40 PF16756.5 EXF86620.1 - 0.036 13.0 0.0 0.23 10.4 0.0 1.9 1 1 1 2 2 2 0 Partner and localizer of BRCA2 WD40 domain Sec16 PF12932.7 EXF86620.1 - 0.045 14.3 0.8 0.2 12.2 0.8 2.2 1 1 0 1 1 1 0 Vesicle coat trafficking protein Sec16 mid-region GET2 PF08690.10 EXF86621.1 - 3.9e-44 151.6 0.0 5.3e-44 151.1 0.0 1.1 1 0 0 1 1 1 1 GET complex subunit GET2 p450 PF00067.22 EXF86622.1 - 2.1e-39 135.6 0.0 3.1e-25 88.8 0.0 2.2 2 0 0 2 2 2 2 Cytochrome P450 HLH PF00010.26 EXF86623.1 - 1.7e-07 31.1 0.0 3.7e-07 30.0 0.0 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain IR1-M PF12185.8 EXF86623.1 - 0.22 11.5 1.7 1.3 9.0 0.0 2.7 2 0 0 2 2 2 0 Nup358/RanBP2 E3 ligase domain GET2 PF08690.10 EXF86623.1 - 3.8 7.1 16.0 1.5 8.4 2.6 2.2 2 0 0 2 2 2 0 GET complex subunit GET2 CDC45 PF02724.14 EXF86623.1 - 4.7 5.4 10.9 8.5 4.5 10.9 1.4 1 0 0 1 1 1 0 CDC45-like protein TMEM135_C_rich PF15982.5 EXF86624.1 - 0.0082 16.7 0.7 0.047 14.3 0.7 2.2 1 1 0 1 1 1 1 N-terminal cysteine-rich region of Transmembrane protein 135 DJ-1_PfpI PF01965.24 EXF86625.1 - 1.9e-19 70.1 0.0 2.8e-19 69.5 0.0 1.2 1 0 0 1 1 1 1 DJ-1/PfpI family SBP_bac_8 PF13416.6 EXF86625.1 - 0.013 15.4 0.0 0.02 14.7 0.0 1.3 1 0 0 1 1 1 0 Bacterial extracellular solute-binding protein GATase PF00117.28 EXF86625.1 - 0.022 14.6 0.0 0.027 14.2 0.0 1.2 1 0 0 1 1 1 0 Glutamine amidotransferase class-I Gp_dh_C PF02800.20 EXF86626.1 - 4e-71 237.7 0.1 6.3e-71 237.1 0.1 1.3 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.24 EXF86626.1 - 6.3e-40 135.6 0.1 1.4e-39 134.5 0.1 1.6 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain DapB_N PF01113.20 EXF86626.1 - 0.0027 17.8 0.2 0.012 15.7 0.2 2.2 1 1 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus ADH_zinc_N PF00107.26 EXF86626.1 - 0.036 14.0 0.1 0.078 13.0 0.1 1.5 1 0 0 1 1 1 0 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 EXF86626.1 - 0.11 11.8 0.2 0.35 10.2 0.0 1.8 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain CENP-F_leu_zip PF10473.9 EXF86628.1 - 2e-05 24.6 44.2 0.0039 17.2 8.5 5.9 3 2 2 5 5 5 3 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 YabA PF06156.13 EXF86628.1 - 0.23 12.1 34.6 0.41 11.3 4.6 6.4 3 2 2 5 5 5 0 Initiation control protein YabA EzrA PF06160.12 EXF86628.1 - 0.26 9.4 45.3 0.025 12.8 9.8 4.6 3 2 1 4 4 4 0 Septation ring formation regulator, EzrA GIT_CC PF16559.5 EXF86628.1 - 0.57 10.1 13.1 0.37 10.7 0.4 4.4 3 1 0 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor bZIP_1 PF00170.21 EXF86628.1 - 0.92 9.6 24.6 1.5 9.0 4.8 6.6 3 2 3 6 6 6 0 bZIP transcription factor Taxilin PF09728.9 EXF86628.1 - 3 6.9 42.8 0.027 13.6 3.1 4.6 4 1 0 4 4 4 0 Myosin-like coiled-coil protein RasGAP_C PF03836.15 EXF86628.1 - 3.1 7.9 40.9 0.18 12.0 0.5 6.0 2 2 4 6 6 6 0 RasGAP C-terminus Baculo_PEP_C PF04513.12 EXF86628.1 - 3.3 7.7 34.4 0.16 12.0 2.5 5.9 5 2 1 6 6 6 0 Baculovirus polyhedron envelope protein, PEP, C terminus Fib_alpha PF08702.10 EXF86628.1 - 4.4 7.5 52.3 0.26 11.5 6.5 6.4 3 1 3 6 6 6 0 Fibrinogen alpha/beta chain family DUF1664 PF07889.12 EXF86628.1 - 5.4 7.1 43.6 0.17 11.9 4.1 6.8 4 2 3 7 7 7 0 Protein of unknown function (DUF1664) Spc7 PF08317.11 EXF86628.1 - 6.5 5.5 62.3 0.12 11.3 14.8 4.8 3 3 2 5 5 5 0 Spc7 kinetochore protein TIP49 PF06068.13 EXF86629.1 - 5.3e-154 512.6 1.6 6.8e-154 512.3 1.6 1.1 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 EXF86629.1 - 9.8e-21 73.7 0.9 3.4e-20 71.9 0.6 2.2 2 0 0 2 2 2 1 TIP49 AAA-lid domain RuvB_N PF05496.12 EXF86629.1 - 3.4e-09 36.6 0.5 3.2e-05 23.7 0.0 2.5 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA PF00004.29 EXF86629.1 - 2.2e-08 34.6 0.5 5e-05 23.7 0.0 3.2 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) DnaB_C PF03796.15 EXF86629.1 - 3.4e-06 26.6 0.9 7.1e-06 25.5 0.9 1.5 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain AAA_16 PF13191.6 EXF86629.1 - 2.6e-05 24.7 0.1 7.4e-05 23.2 0.1 1.9 1 1 0 1 1 1 1 AAA ATPase domain Mg_chelatase PF01078.21 EXF86629.1 - 0.00099 18.5 0.8 0.021 14.2 0.3 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 EXF86629.1 - 0.0057 16.4 0.0 2.2 8.0 0.0 2.4 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_19 PF13245.6 EXF86629.1 - 0.008 16.5 2.0 0.59 10.5 2.0 2.7 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EXF86629.1 - 0.0099 16.2 0.0 0.7 10.2 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 EXF86629.1 - 0.016 15.0 0.9 0.11 12.3 0.1 2.1 1 1 1 2 2 2 0 AAA domain AAA_5 PF07728.14 EXF86629.1 - 0.02 14.9 0.1 3.5 7.6 0.0 2.9 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) Parvo_NS1 PF01057.17 EXF86629.1 - 0.033 13.3 0.0 0.063 12.4 0.0 1.4 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_25 PF13481.6 EXF86629.1 - 0.047 13.3 0.1 0.092 12.3 0.1 1.4 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EXF86629.1 - 0.057 13.6 0.0 0.47 10.6 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 EXF86629.1 - 0.1 12.1 0.1 0.43 10.1 0.0 2.0 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_28 PF13521.6 EXF86629.1 - 0.13 12.5 0.0 0.29 11.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain GYF PF02213.16 EXF86630.1 - 8.3e-12 44.6 2.5 2.7e-11 42.9 2.5 1.9 1 0 0 1 1 1 1 GYF domain GYF_2 PF14237.6 EXF86630.1 - 0.0098 15.7 0.2 0.024 14.4 0.2 1.7 1 0 0 1 1 1 1 GYF domain 2 HTH_WhiA PF02650.14 EXF86630.1 - 0.087 13.2 1.4 0.2 12.0 1.4 1.6 1 0 0 1 1 1 0 WhiA C-terminal HTH domain UFD1 PF03152.14 EXF86631.1 - 7.3e-69 230.7 0.0 9.1e-69 230.4 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 U79_P34 PF03064.16 EXF86635.1 - 0.058 12.7 1.2 0.074 12.4 1.2 1.1 1 0 0 1 1 1 0 HSV U79 / HCMV P34 ORC6 PF05460.13 EXF86635.1 - 0.074 12.3 9.1 0.1 11.9 9.1 1.1 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) RR_TM4-6 PF06459.12 EXF86635.1 - 0.79 9.5 3.9 1.2 8.9 3.9 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Pox_Ag35 PF03286.14 EXF86635.1 - 5.7 6.7 13.1 10 5.8 13.1 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Baculo_LEF5_C PF11792.8 EXF86636.1 - 0.18 11.5 0.2 0.46 10.2 0.2 1.6 1 0 0 1 1 1 0 Baculoviridae late expression factor 5 C-terminal domain PIG-H PF10181.9 EXF86637.1 - 1.1e-26 92.5 0.2 1.7e-26 91.9 0.2 1.3 1 0 0 1 1 1 1 GPI-GlcNAc transferase complex, PIG-H component PseudoU_synth_1 PF01416.20 EXF86638.1 - 3.2e-31 108.0 0.0 1.9e-30 105.5 0.0 2.1 2 0 0 2 2 2 1 tRNA pseudouridine synthase DUF2201_N PF13203.6 EXF86638.1 - 0.11 12.1 3.5 0.95 9.0 0.5 2.4 2 0 0 2 2 2 0 Putative metallopeptidase domain Ras PF00071.22 EXF86639.1 - 1.2e-19 70.5 0.0 1.8e-19 69.9 0.0 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EXF86639.1 - 1.1e-05 25.6 0.0 0.00014 22.0 0.0 2.6 2 1 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EXF86639.1 - 0.0082 15.6 0.0 0.6 9.6 0.0 2.1 2 0 0 2 2 2 1 ADP-ribosylation factor family AAA_24 PF13479.6 EXF86639.1 - 0.051 13.3 0.0 0.087 12.5 0.0 1.5 2 0 0 2 2 2 0 AAA domain SRPRB PF09439.10 EXF86639.1 - 0.064 12.7 0.1 0.15 11.5 0.0 1.6 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit G-alpha PF00503.20 EXF86639.1 - 0.076 12.2 0.0 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 G-protein alpha subunit AAA_25 PF13481.6 EXF86639.1 - 0.18 11.4 0.1 0.56 9.8 0.0 1.7 2 0 0 2 2 2 0 AAA domain RNA_pol_Rpb4 PF03874.16 EXF86640.1 - 3.9e-23 82.1 0.0 4.6e-23 81.9 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb4 Polysacc_deac_2 PF04748.13 EXF86640.1 - 0.014 14.6 0.0 0.026 13.7 0.0 1.4 1 1 0 1 1 1 0 Divergent polysaccharide deacetylase DUF3926 PF13080.6 EXF86640.1 - 0.076 13.0 0.2 0.18 11.8 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3926) Pribosyl_synth PF14572.6 EXF86641.1 - 2.8e-43 148.1 0.8 6.6e-43 146.9 0.8 1.6 1 1 0 1 1 1 1 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.6 EXF86641.1 - 3.4e-32 110.8 0.0 7.6e-32 109.7 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.27 EXF86641.1 - 6.9e-17 61.4 0.3 1.6e-16 60.3 0.1 1.6 2 0 0 2 2 2 1 Phosphoribosyl transferase domain UPRTase PF14681.6 EXF86641.1 - 0.00066 19.2 0.0 0.0011 18.5 0.0 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase DUF5572 PF17733.1 EXF86642.1 - 1.5e-18 66.3 0.4 3.9e-18 65.0 0.4 1.8 1 0 0 1 1 1 1 Family of unknown function (DUF5572) GET2 PF08690.10 EXF86642.1 - 0.029 14.1 3.1 0.037 13.7 3.1 1.2 1 0 0 1 1 1 0 GET complex subunit GET2 FSA_C PF10479.9 EXF86642.1 - 4.4 5.3 5.3 5.6 5.0 5.3 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus PUF PF00806.19 EXF86643.1 - 5.4e-39 129.7 0.8 3.3e-06 26.5 0.0 8.7 9 0 0 9 9 9 7 Pumilio-family RNA binding repeat RasGEF PF00617.19 EXF86643.1 - 0.11 12.7 0.3 0.37 11.0 0.0 2.0 2 0 0 2 2 2 0 RasGEF domain ATP-synt_D PF01813.17 EXF86643.1 - 0.12 12.2 0.4 0.2 11.4 0.4 1.3 1 0 0 1 1 1 0 ATP synthase subunit D DUF4407 PF14362.6 EXF86643.1 - 4.1 6.7 5.5 6 6.1 5.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) MRP-S33 PF08293.11 EXF86644.1 - 6.6e-32 109.6 0.0 8.6e-32 109.2 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit S27 Cupin_4 PF08007.12 EXF86644.1 - 0.094 12.2 0.0 0.59 9.6 0.0 1.8 2 0 0 2 2 2 0 Cupin superfamily protein Ribonuclease_3 PF00636.26 EXF86645.1 - 3e-13 50.3 0.0 8.2e-13 48.9 0.0 1.8 1 0 0 1 1 1 1 Ribonuclease III domain Ribonucleas_3_3 PF14622.6 EXF86645.1 - 1.3e-08 35.1 0.0 5e-08 33.2 0.0 2.0 1 1 1 2 2 2 1 Ribonuclease-III-like dsrm PF00035.26 EXF86645.1 - 0.00035 21.2 0.1 0.00086 20.0 0.1 1.7 1 0 0 1 1 1 1 Double-stranded RNA binding motif BCL9 PF11502.8 EXF86645.1 - 0.051 13.4 0.3 0.12 12.2 0.3 1.6 1 0 0 1 1 1 0 B-cell lymphoma 9 protein PHTB1_C PF14728.6 EXF86645.1 - 0.89 8.6 4.1 5.9 5.9 0.7 2.1 2 0 0 2 2 2 0 PTHB1 C-terminus ACBP PF00887.19 EXF86646.1 - 3.9e-09 36.6 0.1 1.2e-08 35.0 0.1 1.9 1 0 0 1 1 1 1 Acyl CoA binding protein Molybdopterin PF00384.22 EXF86647.1 - 5.2e-74 249.7 0.0 4.1e-72 243.5 0.0 2.2 1 1 0 1 1 1 1 Molybdopterin oxidoreductase Fer2_4 PF13510.6 EXF86647.1 - 3.8e-21 74.9 0.3 8.7e-21 73.8 0.3 1.7 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain NADH_dhqG_C PF09326.11 EXF86647.1 - 2.3e-19 69.8 0.0 8.3e-19 68.0 0.0 2.0 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase subunit G, C-terminal NADH-G_4Fe-4S_3 PF10588.9 EXF86647.1 - 7.9e-17 60.5 0.2 7.9e-17 60.5 0.2 2.2 2 0 0 2 2 2 1 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region Fer2 PF00111.27 EXF86647.1 - 1e-08 35.0 0.8 1e-08 35.0 0.8 2.2 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Lyx_isomer PF07385.12 EXF86647.1 - 0.014 14.7 0.0 0.034 13.4 0.0 1.6 2 0 0 2 2 2 0 D-lyxose isomerase TPP_enzyme_M PF00205.22 EXF86647.1 - 0.021 14.6 0.0 0.21 11.3 0.0 2.2 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain Fer4 PF00037.27 EXF86647.1 - 0.12 12.2 1.1 3.5 7.6 0.3 2.5 2 0 0 2 2 2 0 4Fe-4S binding domain UPF0061 PF02696.14 EXF86648.1 - 1.5e-124 416.3 0.0 1.9e-124 416.0 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized ACR, YdiU/UPF0061 family Aldo_ket_red PF00248.21 EXF86649.1 - 7.3e-40 137.0 0.0 1e-33 116.8 0.0 2.0 2 0 0 2 2 2 2 Aldo/keto reductase family Toprim_Crpt PF13342.6 EXF86649.1 - 0.13 12.2 0.0 0.42 10.6 0.0 1.8 2 0 0 2 2 2 0 C-terminal repeat of topoisomerase XRCC4 PF06632.12 EXF86650.1 - 1.1e-11 44.2 17.0 1.9e-11 43.4 17.0 1.3 1 1 0 1 1 1 1 DNA double-strand break repair and V(D)J recombination protein XRCC4 Roughex PF06020.11 EXF86650.1 - 1.9 7.5 10.4 2.9 6.9 10.4 1.3 1 0 0 1 1 1 0 Drosophila roughex protein SWIRM-assoc_2 PF16496.5 EXF86650.1 - 2.1 7.1 13.3 3.6 6.4 13.3 1.4 1 0 0 1 1 1 0 SWIRM-associated domain at the N-terminal Methyltr_RsmB-F PF01189.17 EXF86652.1 - 2.9e-76 255.6 0.0 7e-76 254.3 0.0 1.6 2 0 0 2 2 2 1 16S rRNA methyltransferase RsmB/F Methyltr_RsmF_N PF17125.5 EXF86652.1 - 6.5e-08 33.0 0.0 1.9e-07 31.5 0.0 1.8 1 0 0 1 1 1 1 N-terminal domain of 16S rRNA methyltransferase RsmF Methyltransf_25 PF13649.6 EXF86652.1 - 0.0038 17.9 0.0 0.012 16.3 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain DUF2431 PF10354.9 EXF86652.1 - 0.0049 17.2 0.0 0.0088 16.3 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF2431) PCMT PF01135.19 EXF86652.1 - 0.018 14.8 0.0 0.032 14.0 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 EXF86652.1 - 0.028 14.2 0.0 0.052 13.3 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain FtsJ PF01728.19 EXF86652.1 - 0.031 14.4 0.0 0.069 13.2 0.0 1.5 1 0 0 1 1 1 0 FtsJ-like methyltransferase SBE2 PF17076.5 EXF86652.1 - 2.6 6.1 10.6 5 5.2 10.6 1.4 1 0 0 1 1 1 0 SBE2, cell-wall formation Blt1 PF12754.7 EXF86653.1 - 9.2e-40 136.4 0.5 1.3e-39 136.0 0.5 1.2 1 0 0 1 1 1 1 Blt1 N-terminal domain Blt1_C PF17183.4 EXF86653.1 - 2.5e-14 52.6 0.9 4.4e-14 51.8 0.9 1.4 1 0 0 1 1 1 1 Get5 carboxyl domain ubiquitin PF00240.23 EXF86653.1 - 0.00018 21.2 0.0 0.00028 20.6 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family Cpn60_TCP1 PF00118.24 EXF86654.1 - 8.2e-87 291.9 12.3 1.5e-86 291.0 12.3 1.4 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family Cofilin_ADF PF00241.20 EXF86654.1 - 4.3e-39 133.0 0.8 8.8e-39 132.1 0.8 1.6 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein DUF3810 PF12725.7 EXF86655.1 - 0.012 15.0 0.0 0.015 14.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) Baculo_PEP_C PF04513.12 EXF86657.1 - 0.0042 17.1 5.1 0.0078 16.3 5.1 1.4 1 0 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus Transferase PF02458.15 EXF86660.1 - 3.7e-17 62.1 0.0 2.2e-10 39.8 0.0 2.1 2 0 0 2 2 2 2 Transferase family Isochorismatase PF00857.20 EXF86661.1 - 3.9e-15 56.5 0.0 6.1e-15 55.8 0.0 1.2 1 0 0 1 1 1 1 Isochorismatase family Cyclin_N PF00134.23 EXF86662.1 - 5.3e-39 132.9 1.1 7.7e-39 132.3 0.2 1.7 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 EXF86662.1 - 2.8e-12 46.7 0.3 1.6e-11 44.4 0.3 2.2 1 1 0 1 1 1 1 Cyclin, C-terminal domain # # Program: hmmscan # Version: 3.2.1 (June 2018) # Pipeline mode: SCAN # Query file: /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Colletotrichum_fioriniae_PJ7-CFIO01/GCA_000582985.1_CFIO01_protein.faa # Target file: /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm # Option settings: /oak/stanford/groups/akundaje/marinovg/programs/hmmer-3.2.1/bin/hmmscan -o /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Colletotrichum_fioriniae_PJ7-CFIO01/GCA_000582985.1_CFIO01_protein.PFam32-A --tblout /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Colletotrichum_fioriniae_PJ7-CFIO01/GCA_000582985.1_CFIO01_protein.PFam32-A.tblout --cpu 20 /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Colletotrichum_fioriniae_PJ7-CFIO01/GCA_000582985.1_CFIO01_protein.faa # Current dir: /oak/stanford/groups/akundaje/marinovg/genomes # Date: Sun Mar 24 17:51:57 2019 # [ok]