# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- DUF3716 PF12511.8 EMD58042.1 - 3.3e-09 36.7 6.1 4.1e-09 36.3 6.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3716) zf-CCHC PF00098.23 EMD58043.1 - 4.3e-06 26.5 13.8 9.3e-06 25.5 1.2 3.1 3 0 0 3 3 3 2 Zinc knuckle zf-CCHC_2 PF13696.6 EMD58043.1 - 0.00042 20.1 0.8 0.00042 20.1 0.8 2.9 4 0 0 4 4 4 1 Zinc knuckle zf-CCHC_4 PF14392.6 EMD58043.1 - 0.0018 17.9 7.5 0.086 12.6 1.7 2.5 2 0 0 2 2 2 2 Zinc knuckle DDE_1 PF03184.19 EMD58048.1 - 8.6e-24 84.1 0.0 9.9e-24 83.9 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.6 EMD58048.1 - 6e-05 22.8 0.1 0.00038 20.2 0.0 1.9 2 0 0 2 2 2 1 DDE superfamily endonuclease AAA_18 PF13238.6 EMD58048.1 - 0.068 13.7 0.0 0.087 13.4 0.0 1.1 1 0 0 1 1 1 0 AAA domain Tk-SP_N-pro PF18237.1 EMD58049.1 - 0.031 14.3 0.0 0.11 12.6 0.0 1.8 2 0 0 2 2 2 0 Tk-SP N-propeptide domain DUF2797 PF10977.8 EMD58051.1 - 0.096 12.6 1.8 0.12 12.3 1.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2797) Zn_clus PF00172.18 EMD58051.1 - 0.22 11.6 7.5 1.1 9.4 7.5 2.0 1 1 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF899 PF05988.12 EMD58051.1 - 0.55 9.7 3.2 0.95 9.0 3.2 1.4 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF899) RVT_1 PF00078.27 EMD58052.1 - 4.6e-06 26.3 0.1 4.6e-06 26.3 0.1 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DDDD PF10161.9 EMD58052.1 - 0.19 11.5 0.0 0.21 11.3 0.0 1.1 1 0 0 1 1 1 0 Putative mitochondrial precursor protein Vpu PF00558.19 EMD58056.1 - 0.9 9.4 4.3 1.8 8.4 4.3 1.4 1 0 0 1 1 1 0 Vpu protein HYLS1_C PF15311.6 EMD58057.1 - 0.041 14.6 0.0 0.044 14.5 0.0 1.0 1 0 0 1 1 1 0 Hydrolethalus syndrome protein 1 C-terminus SRX PF09201.10 EMD58058.1 - 0.053 13.4 0.0 0.059 13.2 0.0 1.1 1 0 0 1 1 1 0 SRX, signal recognition particle receptor alpha subunit RVP_2 PF08284.11 EMD58059.1 - 0.0014 18.4 0.0 0.0014 18.4 0.0 1.0 1 0 0 1 1 1 1 Retroviral aspartyl protease ImpE PF07024.13 EMD58060.1 - 0.039 14.0 0.0 0.042 13.9 0.0 1.1 1 0 0 1 1 1 0 ImpE protein MukE PF04288.13 EMD58061.1 - 0.038 12.9 0.1 0.045 12.7 0.1 1.2 1 0 0 1 1 1 0 MukE-like family ETM PF17577.2 EMD58061.1 - 0.067 13.8 0.0 0.08 13.5 0.0 1.2 1 0 0 1 1 1 0 ECORI-T site zf-CCHC PF00098.23 EMD58062.1 - 2.3e-06 27.4 1.2 3.3e-06 26.9 1.2 1.2 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_2 PF13696.6 EMD58062.1 - 0.00011 21.9 0.8 0.00015 21.5 0.8 1.2 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_5 PF14787.6 EMD58062.1 - 0.084 12.6 1.4 0.14 11.9 1.4 1.3 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger Sterol_MT_C PF08498.10 EMD58064.1 - 0.092 13.1 0.0 2.3 8.6 0.0 2.4 1 1 1 2 2 2 0 Sterol methyltransferase C-terminal DUF4174 PF13778.6 EMD58067.1 - 0.042 14.3 1.5 0.07 13.6 1.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4174) Golgin_A5 PF09787.9 EMD58067.1 - 0.68 9.3 8.6 0.035 13.6 3.0 1.6 2 0 0 2 2 2 0 Golgin subfamily A member 5 RVP_2 PF08284.11 EMD58070.1 - 0.0013 18.5 0.1 0.0016 18.3 0.1 1.1 1 0 0 1 1 1 1 Retroviral aspartyl protease HTH_Tnp_Tc5 PF03221.16 EMD58072.1 - 3.3e-09 36.6 0.1 6.2e-09 35.8 0.1 1.5 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EMD58072.1 - 0.0013 18.5 0.1 0.002 17.9 0.1 1.3 1 0 0 1 1 1 1 helix-turn-helix, Psq domain Drf_GBD PF06371.13 EMD58072.1 - 0.014 15.0 0.0 0.015 14.9 0.0 1.1 1 0 0 1 1 1 0 Diaphanous GTPase-binding Domain Ribosomal_S13_N PF08069.12 EMD58072.1 - 0.024 14.7 0.0 0.042 13.9 0.0 1.4 1 0 0 1 1 1 0 Ribosomal S13/S15 N-terminal domain TnsD PF15978.5 EMD58072.1 - 0.025 13.6 0.4 0.028 13.4 0.4 1.1 1 0 0 1 1 1 0 Tn7-like transposition protein D Cdc6_C PF09079.11 EMD58072.1 - 0.045 13.7 0.0 6.9 6.7 0.0 2.4 2 0 0 2 2 2 0 CDC6, C terminal winged helix domain HTH_24 PF13412.6 EMD58072.1 - 0.067 12.8 0.1 0.57 9.8 0.0 2.2 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding DUF2721 PF11026.8 EMD58072.1 - 0.32 10.9 1.0 0.58 10.0 1.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2721) DDE_1 PF03184.19 EMD58073.1 - 1.4e-08 34.6 0.0 2.6e-08 33.7 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF4407 PF14362.6 EMD58073.1 - 0.32 10.3 15.6 0.42 9.9 15.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) YabA PF06156.13 EMD58073.1 - 0.39 11.4 0.1 0.39 11.4 0.1 2.2 2 0 0 2 2 2 0 Initiation control protein YabA DDE_3 PF13358.6 EMD58074.1 - 1.1e-08 35.0 0.2 2.4e-08 33.8 0.0 1.5 2 0 0 2 2 2 1 DDE superfamily endonuclease DUF2789 PF10982.8 EMD58074.1 - 0.11 12.7 0.1 0.14 12.3 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2789) zf-CCHC PF00098.23 EMD58078.1 - 0.07 13.2 0.1 0.11 12.6 0.1 1.3 1 0 0 1 1 1 0 Zinc knuckle Thioesterase PF00975.20 EMD58079.1 - 0.012 15.7 0.0 0.014 15.6 0.0 1.0 1 0 0 1 1 1 0 Thioesterase domain RVT_1 PF00078.27 EMD58082.1 - 6.5e-06 25.8 0.1 6.5e-06 25.8 0.1 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DDDD PF10161.9 EMD58082.1 - 0.04 13.7 0.0 0.045 13.5 0.0 1.1 1 0 0 1 1 1 0 Putative mitochondrial precursor protein RVT_1 PF00078.27 EMD58083.1 - 4.7e-10 39.4 0.1 5e-10 39.3 0.1 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) SeleniumBinding PF11524.8 EMD58083.1 - 0.023 15.1 0.1 0.027 14.9 0.1 1.1 1 0 0 1 1 1 0 Selenium binding protein DUF4894 PF16235.5 EMD58083.1 - 0.037 14.4 0.5 0.042 14.2 0.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4894) Peptidase_S15 PF02129.18 EMD58084.1 - 0.3 10.6 3.4 0.27 10.8 2.4 1.4 1 1 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Exo_endo_phos_2 PF14529.6 EMD58085.1 - 3.2e-18 65.7 0.7 3.5e-18 65.6 0.7 1.0 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Zwilch PF09817.9 EMD58086.1 - 0.014 13.9 0.0 0.014 13.9 0.0 1.0 1 0 0 1 1 1 0 RZZ complex, subunit zwilch Integrase_H2C2 PF17921.1 EMD58086.1 - 0.058 13.5 0.0 0.065 13.3 0.0 1.1 1 0 0 1 1 1 0 Integrase zinc binding domain GTP_cyclohydroI PF01227.22 EMD58087.1 - 0.17 11.3 0.0 0.18 11.2 0.0 1.0 1 0 0 1 1 1 0 GTP cyclohydrolase I HTH_psq PF05225.16 EMD58089.1 - 0.00041 20.0 0.1 0.00061 19.5 0.1 1.3 1 0 0 1 1 1 1 helix-turn-helix, Psq domain zf-CCHC PF00098.23 EMD58091.1 - 0.22 11.7 3.2 0.36 11.0 3.2 1.3 1 0 0 1 1 1 0 Zinc knuckle HemY_N PF07219.13 EMD58091.1 - 0.81 9.9 4.0 0.88 9.8 4.0 1.2 1 0 0 1 1 1 0 HemY protein N-terminus Integrase_H2C2 PF17921.1 EMD58092.1 - 1.5e-06 28.2 0.0 2.2e-06 27.7 0.0 1.3 1 0 0 1 1 1 1 Integrase zinc binding domain HTH_29 PF13551.6 EMD58095.1 - 2.3e-06 27.5 0.1 3.5e-06 26.9 0.1 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_32 PF13565.6 EMD58095.1 - 9.8e-06 26.1 0.3 0.0026 18.3 0.2 2.0 1 1 1 2 2 2 1 Homeodomain-like domain HTH_23 PF13384.6 EMD58095.1 - 6.9e-05 22.5 0.1 0.00015 21.5 0.1 1.5 1 0 0 1 1 1 1 Homeodomain-like domain HTH_Tnp_Tc3_1 PF11427.8 EMD58095.1 - 8.8e-05 22.3 0.2 0.00021 21.1 0.0 1.7 2 0 0 2 2 2 1 Tc3 transposase Sigma70_r4_2 PF08281.12 EMD58095.1 - 8.8e-05 22.1 0.0 8.8e-05 22.1 0.0 1.5 2 0 0 2 2 2 1 Sigma-70, region 4 HTH_24 PF13412.6 EMD58095.1 - 0.00013 21.4 0.6 0.039 13.5 0.2 2.3 2 0 0 2 2 2 2 Winged helix-turn-helix DNA-binding HTH_11 PF08279.12 EMD58095.1 - 0.00032 20.6 0.0 0.00089 19.2 0.0 1.8 1 1 1 2 2 2 1 HTH domain HTH_38 PF13936.6 EMD58095.1 - 0.0014 18.3 0.7 0.0022 17.7 0.1 1.6 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_28 PF13518.6 EMD58095.1 - 0.0016 18.5 0.1 0.0024 18.0 0.1 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_Mga PF08280.11 EMD58095.1 - 0.0019 18.2 0.0 0.0036 17.3 0.0 1.4 1 0 0 1 1 1 1 M protein trans-acting positive regulator (MGA) HTH domain HTH_Crp_2 PF13545.6 EMD58095.1 - 0.003 17.5 0.1 0.0036 17.2 0.1 1.3 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain HTH_AsnC-type PF13404.6 EMD58095.1 - 0.017 15.0 0.6 7.1 6.6 0.0 2.5 3 0 0 3 3 3 0 AsnC-type helix-turn-helix domain HTH_7 PF02796.15 EMD58095.1 - 0.023 14.8 0.6 0.89 9.7 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain of resolvase PAX PF00292.18 EMD58095.1 - 0.042 13.8 0.0 0.049 13.6 0.0 1.0 1 0 0 1 1 1 0 'Paired box' domain FeoC PF09012.10 EMD58095.1 - 0.044 13.9 0.0 0.066 13.3 0.0 1.3 1 0 0 1 1 1 0 FeoC like transcriptional regulator Sigma70_r4 PF04545.16 EMD58095.1 - 0.045 13.3 0.1 0.095 12.2 0.0 1.6 2 0 0 2 2 2 0 Sigma-70, region 4 SgrR_N PF12793.7 EMD58095.1 - 0.055 13.7 0.3 0.14 12.4 0.1 1.6 1 1 1 2 2 2 0 Sugar transport-related sRNA regulator N-term TnsD PF15978.5 EMD58095.1 - 0.06 12.3 0.0 0.06 12.3 0.0 1.0 1 0 0 1 1 1 0 Tn7-like transposition protein D MarR PF01047.22 EMD58095.1 - 0.071 13.0 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 MarR family Helicase_C PF00271.31 EMD58098.1 - 1.2e-06 28.9 0.0 2.8e-06 27.6 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain RecQ_Zn_bind PF16124.5 EMD58098.1 - 0.00064 20.4 0.8 0.00064 20.4 0.8 3.2 3 1 0 3 3 3 1 RecQ zinc-binding Tom22 PF04281.13 EMD58098.1 - 4.4 7.1 11.8 5 6.9 8.1 2.8 3 0 0 3 3 3 0 Mitochondrial import receptor subunit Tom22 ArAE_2_N PF10337.9 EMD58098.1 - 7.5 5.5 5.7 10 5.0 5.7 1.2 1 0 0 1 1 1 0 Putative ER transporter, 6TM, N-terminal MscS_TM PF12794.7 EMD58098.1 - 9 5.0 9.4 16 4.2 9.4 1.3 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 DEAD PF00270.29 EMD58099.1 - 2e-06 27.7 0.0 2.1e-06 27.6 0.0 1.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 EMD58099.1 - 0.00064 19.8 0.0 0.00067 19.7 0.0 1.1 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit PhoH PF02562.16 EMD58099.1 - 0.071 12.5 0.0 0.079 12.4 0.0 1.2 1 0 0 1 1 1 0 PhoH-like protein ImpE PF07024.13 EMD58100.1 - 0.038 14.1 0.0 0.041 14.0 0.0 1.1 1 0 0 1 1 1 0 ImpE protein RVP_2 PF08284.11 EMD58101.1 - 0.0075 16.0 0.0 0.0075 16.0 0.0 1.1 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease PF09668.10 EMD58101.1 - 0.17 11.7 0.0 0.2 11.5 0.0 1.1 1 0 0 1 1 1 0 Aspartyl protease WCCH PF03716.14 EMD58102.1 - 1.4e-05 24.6 0.1 1.4e-05 24.6 0.1 3.2 4 0 0 4 4 4 2 WCCH motif zf_CopZ PF18423.1 EMD58102.1 - 0.022 14.7 0.6 0.51 10.3 0.1 2.3 2 0 0 2 2 2 0 Zinc binding domain TAXi_N PF14543.6 EMD58102.1 - 0.58 10.4 5.7 0.98 9.6 5.7 1.3 1 1 0 1 1 1 0 Xylanase inhibitor N-terminal Condensation PF00668.20 EMD58104.1 - 3.8e-56 190.7 0.2 8.2e-37 126.9 0.0 3.1 2 2 0 2 2 2 2 Condensation domain PP-binding PF00550.25 EMD58104.1 - 5.2e-07 29.9 0.4 3.9e-06 27.1 0.1 2.5 2 0 0 2 2 2 1 Phosphopantetheine attachment site RVT_1 PF00078.27 EMD58106.1 - 0.00035 20.2 0.1 0.00035 20.2 0.1 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) SERTA PF06031.13 EMD58107.1 - 0.0032 17.1 0.0 0.0078 15.9 0.0 1.6 1 0 0 1 1 1 1 SERTA motif Exo_endo_phos_2 PF14529.6 EMD58108.1 - 1.1e-16 60.7 0.4 1.2e-16 60.6 0.4 1.0 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Condensation PF00668.20 EMD58109.1 - 3.8e-52 177.5 0.1 5.3e-52 177.0 0.1 1.2 1 0 0 1 1 1 1 Condensation domain AMP-binding PF00501.28 EMD58109.1 - 2.1e-39 135.3 0.0 1.2e-27 96.6 0.0 2.4 2 0 0 2 2 2 2 AMP-binding enzyme PP-binding PF00550.25 EMD58109.1 - 1.5e-16 60.4 0.0 3.1e-15 56.3 0.0 2.9 2 0 0 2 2 2 1 Phosphopantetheine attachment site AMP-binding_C PF13193.6 EMD58109.1 - 0.0081 17.1 0.0 0.021 15.8 0.0 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Cas1_AcylT PF07779.12 EMD58109.1 - 0.038 12.9 0.0 0.058 12.3 0.0 1.2 1 0 0 1 1 1 0 10 TM Acyl Transferase domain found in Cas1p Exo_endo_phos_2 PF14529.6 EMD58110.1 - 3.5e-12 46.2 0.0 1.5e-11 44.1 0.0 2.0 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 EMD58110.1 - 0.033 13.7 0.0 0.041 13.4 0.0 1.3 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family YfcL PF08891.11 EMD58110.1 - 0.11 12.8 0.2 0.21 11.9 0.2 1.3 1 0 0 1 1 1 0 YfcL protein API5 PF05918.11 EMD58115.1 - 4.6 5.9 4.8 5.3 5.7 4.8 1.0 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) Lambda_CIII PF02061.16 EMD58117.1 - 0.022 14.8 0.0 0.035 14.2 0.0 1.3 1 0 0 1 1 1 0 Lambda Phage CIII VWA PF00092.28 EMD58119.1 - 0.057 13.7 0.1 0.12 12.6 0.0 1.5 1 1 0 1 1 1 0 von Willebrand factor type A domain DDRGK PF09756.9 EMD58119.1 - 0.93 9.0 15.0 1.7 8.2 15.0 1.3 1 0 0 1 1 1 0 DDRGK domain YabA PF06156.13 EMD58119.1 - 0.96 10.1 6.8 0.24 12.1 1.0 2.2 1 1 1 2 2 2 0 Initiation control protein YabA DUF4174 PF13778.6 EMD58121.1 - 0.042 14.3 1.5 0.07 13.6 1.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4174) Zn_clus PF00172.18 EMD58121.1 - 0.37 10.9 6.9 1.8 8.8 1.9 2.0 1 1 1 2 2 2 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Golgin_A5 PF09787.9 EMD58121.1 - 1.4 8.3 9.5 0.051 13.0 3.5 1.6 2 0 0 2 2 2 0 Golgin subfamily A member 5 TPR_10 PF13374.6 EMD58122.1 - 1.3e-19 69.4 0.3 3.4e-09 36.3 0.1 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat NB-ARC PF00931.22 EMD58122.1 - 3.8e-14 52.5 0.0 6.7e-14 51.7 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain TPR_12 PF13424.6 EMD58122.1 - 1.5e-12 47.6 0.0 5.4e-12 45.8 0.0 2.0 1 0 0 1 1 1 1 Tetratricopeptide repeat HET PF06985.11 EMD58122.1 - 3.5e-12 46.9 11.7 1.9e-09 38.0 6.0 3.2 2 1 1 3 3 2 2 Heterokaryon incompatibility protein (HET) AAA_16 PF13191.6 EMD58122.1 - 7.4e-10 39.5 0.6 1.3e-08 35.4 0.0 2.8 2 0 0 2 2 2 1 AAA ATPase domain TPR_7 PF13176.6 EMD58122.1 - 2.5e-08 33.3 1.1 0.00018 21.3 0.0 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat AAA_22 PF13401.6 EMD58122.1 - 4.3e-06 27.0 0.1 2.8e-05 24.4 0.0 2.4 2 1 1 3 3 3 1 AAA domain ATPase_2 PF01637.18 EMD58122.1 - 2.7e-05 24.2 0.0 6.4e-05 23.0 0.0 1.6 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea TPR_2 PF07719.17 EMD58122.1 - 2.8e-05 23.9 0.1 0.65 10.3 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat AAA PF00004.29 EMD58122.1 - 0.00018 21.9 0.0 0.0015 19.0 0.0 2.5 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 EMD58122.1 - 0.00046 20.1 0.5 0.0014 18.5 0.1 2.2 2 0 0 2 2 2 1 NACHT domain TniB PF05621.11 EMD58122.1 - 0.0007 19.1 0.0 0.0021 17.5 0.0 1.8 2 0 0 2 2 1 1 Bacterial TniB protein IstB_IS21 PF01695.17 EMD58122.1 - 0.0041 16.9 0.0 0.011 15.4 0.0 1.7 1 0 0 1 1 1 1 IstB-like ATP binding protein TPR_19 PF14559.6 EMD58122.1 - 0.0055 17.2 0.0 0.019 15.4 0.0 2.0 1 0 0 1 1 1 1 Tetratricopeptide repeat PPR PF01535.20 EMD58122.1 - 0.0059 16.8 0.6 5.8 7.4 0.3 2.8 2 0 0 2 2 2 1 PPR repeat TPR_1 PF00515.28 EMD58122.1 - 0.016 15.0 0.4 2.4 8.1 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_4 PF07721.14 EMD58122.1 - 0.017 15.7 0.3 9.7 7.2 0.0 3.5 3 0 0 3 3 2 0 Tetratricopeptide repeat Sigma54_activ_2 PF14532.6 EMD58122.1 - 0.041 14.0 0.1 0.37 10.9 0.1 2.4 1 1 0 1 1 1 0 Sigma-54 interaction domain AAA_24 PF13479.6 EMD58122.1 - 0.054 13.2 0.1 0.16 11.6 0.0 1.9 2 0 0 2 2 1 0 AAA domain SRP54 PF00448.22 EMD58122.1 - 0.058 13.0 0.1 0.61 9.7 0.0 2.7 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain DnaB_C PF03796.15 EMD58122.1 - 0.059 12.7 0.0 0.12 11.7 0.0 1.4 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain STD1 PF17235.2 EMD58122.1 - 0.11 12.1 2.0 0.33 10.6 0.1 2.5 2 1 0 2 2 2 0 STD1/MTH1 PPR_1 PF12854.7 EMD58122.1 - 0.11 12.2 0.9 5.8 6.7 0.4 2.4 2 0 0 2 2 2 0 PPR repeat Cytidylate_kin PF02224.18 EMD58122.1 - 0.12 12.1 0.0 0.25 11.0 0.0 1.6 1 0 0 1 1 1 0 Cytidylate kinase TPR_17 PF13431.6 EMD58122.1 - 0.15 12.5 0.3 2.3 8.8 0.0 3.0 3 0 0 3 3 2 0 Tetratricopeptide repeat AAA_33 PF13671.6 EMD58122.1 - 0.73 10.0 4.0 8.3 6.6 0.0 3.5 5 0 0 5 5 3 0 AAA domain PPR_2 PF13041.6 EMD58122.1 - 0.79 10.0 2.7 32 4.8 0.2 2.8 3 0 0 3 3 2 0 PPR repeat family HemY_N PF07219.13 EMD58123.1 - 0.26 11.5 3.0 0.32 11.2 3.0 1.2 1 0 0 1 1 1 0 HemY protein N-terminus Condensation PF00668.20 EMD58124.1 - 7.1e-36 123.8 0.0 1.1e-35 123.2 0.0 1.2 1 0 0 1 1 1 1 Condensation domain PP-binding PF00550.25 EMD58124.1 - 3.2e-17 62.6 0.0 1.3e-16 60.6 0.0 2.1 2 0 0 2 2 2 1 Phosphopantetheine attachment site zf-CCHC PF00098.23 EMD58125.1 - 0.16 12.1 3.2 0.26 11.4 3.2 1.3 1 0 0 1 1 1 0 Zinc knuckle RNase_H PF00075.24 EMD58126.1 - 0.00013 22.2 0.1 0.00023 21.4 0.1 1.4 1 0 0 1 1 1 1 RNase H DUF3716 PF12511.8 EMD58127.1 - 3.4e-08 33.4 5.8 5.2e-08 32.8 5.8 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3716) DUF4183 PF13799.6 EMD58129.1 - 0.019 14.8 0.0 0.021 14.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4183) R2K_3 PF14243.6 EMD58129.1 - 0.03 14.3 0.0 0.045 13.8 0.0 1.3 1 0 0 1 1 1 0 ATP-grasp domain, R2K clade family 3 Exo_endo_phos_2 PF14529.6 EMD58133.1 - 6.6e-15 55.0 0.9 7.2e-15 54.9 0.9 1.0 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Cas_Csy4 PF09618.10 EMD58134.1 - 0.03 14.5 3.8 0.58 10.3 2.3 2.2 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_Csy4) Tk-SP_N-pro PF18237.1 EMD58134.1 - 0.12 12.4 0.0 0.41 10.7 0.0 1.8 2 0 0 2 2 2 0 Tk-SP N-propeptide domain Robl_LC7 PF03259.17 EMD58134.1 - 0.46 10.3 3.0 1.1 9.0 0.4 2.4 2 1 1 3 3 3 0 Roadblock/LC7 domain DUF4907 PF16250.5 EMD58134.1 - 0.48 10.3 2.3 8.5 6.3 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4907) Ribosomal_60s PF00428.19 EMD58138.1 - 0.016 15.8 16.8 0.016 15.8 16.8 2.7 3 0 0 3 3 3 0 60s Acidic ribosomal protein SDH_alpha PF03313.15 EMD58138.1 - 1.3 8.6 9.7 2.2 7.9 9.7 1.3 1 0 0 1 1 1 0 Serine dehydratase alpha chain DUF2057 PF09829.9 EMD58138.1 - 3.8 7.6 5.1 2.9 8.0 1.4 2.0 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2057) RVP_2 PF08284.11 EMD58140.1 - 4.9e-06 26.3 0.0 6.5e-06 26.0 0.0 1.1 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.6 EMD58140.1 - 1.4e-05 25.5 0.0 2.3e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 EMD58140.1 - 2.6e-05 24.8 0.0 4.1e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 Aspartyl protease Asp_protease PF09668.10 EMD58140.1 - 0.0049 16.6 0.2 0.011 15.5 0.2 1.6 1 1 0 1 1 1 1 Aspartyl protease zf-CCHC PF00098.23 EMD58141.1 - 0.22 11.7 3.2 0.36 11.0 3.2 1.3 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_5 PF14787.6 EMD58146.1 - 0.016 14.9 1.2 0.032 13.9 1.2 1.5 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger zf-CCHC_2 PF13696.6 EMD58146.1 - 0.027 14.3 4.1 0.056 13.3 4.1 1.5 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC PF00098.23 EMD58146.1 - 0.12 12.5 1.5 0.18 11.9 1.5 1.3 1 0 0 1 1 1 0 Zinc knuckle Ank_2 PF12796.7 EMD58147.1 - 1.7e-28 99.0 0.3 1.8e-14 54.1 0.4 2.0 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 EMD58147.1 - 1.6e-24 85.2 5.0 2e-05 24.8 0.0 5.0 5 0 0 5 5 5 5 Ankyrin repeat Ank_4 PF13637.6 EMD58147.1 - 2.1e-24 85.5 0.4 1e-09 38.7 0.0 3.1 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMD58147.1 - 2.8e-23 79.5 0.3 0.0007 19.9 0.0 5.0 4 1 1 5 5 5 5 Ankyrin repeat Ank_5 PF13857.6 EMD58147.1 - 2.5e-22 78.6 4.9 6e-10 39.2 0.0 3.9 1 1 3 4 4 4 4 Ankyrin repeats (many copies) PEGA PF08308.11 EMD58147.1 - 0.0022 17.9 0.0 9.1 6.3 0.0 3.3 3 0 0 3 3 3 2 PEGA domain DUF4427 PF14468.6 EMD58147.1 - 0.014 15.4 2.6 19 5.3 0.0 3.6 1 1 3 4 4 4 0 Protein of unknown function (DUF4427) Imm_superinfect PF14373.6 EMD58147.1 - 0.021 14.8 2.0 38 4.3 0.1 4.2 5 0 0 5 5 5 0 Superinfection immunity protein TFIIE_beta PF02186.15 EMD58147.1 - 0.15 12.4 0.0 58 4.1 0.0 3.0 1 1 2 3 3 3 0 TFIIE beta subunit core domain VWA_3_C PF18571.1 EMD58147.1 - 1.2 9.1 11.1 16 5.4 0.2 4.2 5 0 0 5 5 5 0 von Willebrand factor type A C-terminal domain Ank_2 PF12796.7 EMD58148.1 - 1.6e-15 57.5 0.0 5e-12 46.3 0.0 2.0 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EMD58148.1 - 7e-14 50.6 0.3 1.1e-05 25.4 0.0 3.1 3 0 0 3 3 3 3 Ankyrin repeat Ank PF00023.30 EMD58148.1 - 5.1e-13 48.8 0.5 8e-06 26.1 0.0 3.1 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.6 EMD58148.1 - 5.2e-12 46.0 0.1 5e-11 42.9 0.0 2.0 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 EMD58148.1 - 3.7e-09 36.7 0.2 3.9e-07 30.2 0.0 2.2 1 1 1 2 2 2 2 Ankyrin repeats (many copies) VWA_3_C PF18571.1 EMD58148.1 - 0.59 10.0 3.2 3.1 7.7 0.1 2.7 3 1 0 3 3 3 0 von Willebrand factor type A C-terminal domain HET PF06985.11 EMD58149.1 - 3.1e-12 47.1 8.8 1.8e-09 38.1 0.6 2.3 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) RE_SacI PF09566.10 EMD58151.1 - 0.096 12.5 0.1 0.096 12.5 0.1 1.1 1 0 0 1 1 1 0 SacI restriction endonuclease Chromo PF00385.24 EMD58152.1 - 2.3e-07 30.6 1.0 4.1e-07 29.8 1.0 1.4 1 1 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Chromo_shadow PF01393.19 EMD58152.1 - 0.035 14.2 0.0 0.054 13.6 0.0 1.3 1 0 0 1 1 1 0 Chromo shadow domain RVP_2 PF08284.11 EMD58157.1 - 0.00064 19.5 0.0 0.00064 19.5 0.0 1.0 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease PF09668.10 EMD58157.1 - 0.048 13.5 0.0 0.056 13.2 0.0 1.1 1 0 0 1 1 1 0 Aspartyl protease zf-CCHC PF00098.23 EMD58158.1 - 8.2e-07 28.8 10.6 2.8e-05 24.0 1.2 3.6 3 0 0 3 3 3 2 Zinc knuckle zf-CCHC_2 PF13696.6 EMD58158.1 - 0.00084 19.1 0.8 0.00084 19.1 0.8 2.3 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_4 PF14392.6 EMD58158.1 - 0.0035 17.0 4.1 0.96 9.2 0.4 2.5 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_5 PF14787.6 EMD58158.1 - 4.5 7.1 11.7 1.6 8.5 1.1 3.1 3 0 0 3 3 3 0 GAG-polyprotein viral zinc-finger Gon7 PF08738.10 EMD58159.1 - 0.035 14.2 0.0 0.044 13.9 0.0 1.2 1 0 0 1 1 1 0 Gon7 family HCMV_UL124 PF17609.2 EMD58160.1 - 0.03 14.5 1.1 0.04 14.1 1.1 1.3 1 0 0 1 1 1 0 Family of unknown function DUF979 PF06166.12 EMD58160.1 - 0.034 13.3 0.1 0.037 13.2 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF979) DUF5417 PF17438.2 EMD58160.1 - 0.11 12.9 0.0 0.14 12.4 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5417) TPR_10 PF13374.6 EMD58161.1 - 1.8e-16 59.4 1.3 1.3e-08 34.4 0.1 2.0 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 EMD58161.1 - 8.2e-12 45.2 0.1 9.5e-12 45.0 0.1 1.0 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_7 PF13176.6 EMD58161.1 - 0.0031 17.4 0.7 1.3 9.3 0.1 2.1 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 EMD58161.1 - 0.06 13.5 0.6 14 6.1 0.3 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat RNase_H PF00075.24 EMD58169.1 - 1.5e-07 31.7 0.0 2.5e-07 30.9 0.0 1.4 1 1 0 1 1 1 1 RNase H DpnI_C PF17726.1 EMD58169.1 - 0.042 14.0 0.0 0.06 13.5 0.0 1.2 1 0 0 1 1 1 0 Dam-replacing HTH domain RRM_1 PF00076.22 EMD58171.1 - 0.059 13.2 0.1 0.2 11.5 0.1 2.0 1 1 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) EpsG PF14897.6 EMD58172.1 - 0.015 14.6 0.2 0.019 14.3 0.2 1.1 1 0 0 1 1 1 0 EpsG family Methyltransf_2 PF00891.18 EMD58174.1 - 2.1e-19 69.6 0.0 3.7e-19 68.9 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain GD_AH_C PF04295.13 EMD58174.1 - 0.055 12.3 0.0 0.098 11.4 0.0 1.4 1 0 0 1 1 1 0 D-galactarate dehydratase / Altronate hydrolase, C terminus Thioesterase PF00975.20 EMD58175.1 - 4e-20 72.9 0.0 2.3e-17 63.9 0.0 2.1 2 0 0 2 2 2 2 Thioesterase domain Abhydrolase_6 PF12697.7 EMD58175.1 - 1.5e-06 29.0 0.0 1.7e-06 28.8 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EMD58175.1 - 2.6e-06 27.3 0.3 3.1e-06 27.0 0.3 1.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold DUF2974 PF11187.8 EMD58175.1 - 0.00067 19.3 0.0 0.0013 18.4 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2974) Abhydrolase_3 PF07859.13 EMD58175.1 - 0.0061 16.4 0.1 0.031 14.2 0.0 1.9 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 EMD58175.1 - 0.017 15.0 0.0 0.024 14.4 0.0 1.4 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase HTH_29 PF13551.6 EMD58178.1 - 2.6e-06 27.3 0.1 4e-06 26.7 0.1 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_32 PF13565.6 EMD58178.1 - 1.1e-05 25.9 0.3 0.003 18.1 0.2 2.0 1 1 1 2 2 2 1 Homeodomain-like domain HTH_23 PF13384.6 EMD58178.1 - 7.7e-05 22.4 0.1 0.00016 21.3 0.1 1.5 1 0 0 1 1 1 1 Homeodomain-like domain HTH_Tnp_Tc3_1 PF11427.8 EMD58178.1 - 9.2e-05 22.2 0.2 0.00024 20.9 0.0 1.7 2 0 0 2 2 2 1 Tc3 transposase Sigma70_r4_2 PF08281.12 EMD58178.1 - 9.4e-05 22.0 1.0 0.0001 21.9 0.0 1.5 2 0 0 2 2 2 1 Sigma-70, region 4 HTH_24 PF13412.6 EMD58178.1 - 0.00016 21.2 0.6 0.044 13.4 0.2 2.3 2 0 0 2 2 2 2 Winged helix-turn-helix DNA-binding HTH_11 PF08279.12 EMD58178.1 - 0.00036 20.4 0.0 0.00099 19.0 0.0 1.7 1 1 1 2 2 2 1 HTH domain HTH_38 PF13936.6 EMD58178.1 - 0.0016 18.1 0.7 0.0025 17.5 0.1 1.6 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_28 PF13518.6 EMD58178.1 - 0.0018 18.3 0.1 0.0027 17.8 0.1 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_Mga PF08280.11 EMD58178.1 - 0.0021 18.1 0.0 0.0039 17.2 0.0 1.4 1 0 0 1 1 1 1 M protein trans-acting positive regulator (MGA) HTH domain HTH_Crp_2 PF13545.6 EMD58178.1 - 0.0034 17.3 0.1 0.0042 17.0 0.1 1.3 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain HTH_AsnC-type PF13404.6 EMD58178.1 - 0.019 14.8 0.5 7.7 6.4 0.0 2.6 3 0 0 3 3 3 0 AsnC-type helix-turn-helix domain HTH_7 PF02796.15 EMD58178.1 - 0.027 14.5 0.6 0.99 9.5 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain of resolvase PAX PF00292.18 EMD58178.1 - 0.046 13.6 0.0 0.053 13.4 0.0 1.1 1 0 0 1 1 1 0 'Paired box' domain FeoC PF09012.10 EMD58178.1 - 0.048 13.7 0.0 0.077 13.1 0.0 1.3 1 0 0 1 1 1 0 FeoC like transcriptional regulator Sigma70_r4 PF04545.16 EMD58178.1 - 0.052 13.1 0.1 0.11 12.1 0.0 1.6 2 0 0 2 2 2 0 Sigma-70, region 4 TnsD PF15978.5 EMD58178.1 - 0.052 12.5 0.0 0.054 12.5 0.0 1.0 1 0 0 1 1 1 0 Tn7-like transposition protein D SgrR_N PF12793.7 EMD58178.1 - 0.063 13.5 0.3 0.16 12.2 0.1 1.6 1 1 1 2 2 2 0 Sugar transport-related sRNA regulator N-term MarR PF01047.22 EMD58178.1 - 0.079 12.9 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 MarR family RHH_4 PF13467.6 EMD58178.1 - 0.086 12.7 0.0 1 9.3 0.0 2.1 2 0 0 2 2 2 0 Ribbon-helix-helix domain DUF3716 PF12511.8 EMD58181.1 - 4e-07 30.0 4.5 6.7e-07 29.3 4.5 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3716) MIase PF02426.16 EMD58181.1 - 0.16 12.2 0.0 0.26 11.5 0.0 1.3 1 0 0 1 1 1 0 Muconolactone delta-isomerase Exo_endo_phos_2 PF14529.6 EMD58183.1 - 2e-17 63.1 0.8 2.2e-17 63.0 0.8 1.0 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase zf-CCHC PF00098.23 EMD58185.1 - 0.11 12.6 3.0 0.18 11.9 3.0 1.3 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_2 PF13696.6 EMD58185.1 - 0.22 11.4 1.1 0.29 11.0 1.1 1.2 1 0 0 1 1 1 0 Zinc knuckle HemY_N PF07219.13 EMD58185.1 - 0.95 9.7 3.5 1.2 9.4 3.5 1.1 1 0 0 1 1 1 0 HemY protein N-terminus Baculo_E56 PF04639.12 EMD58186.1 - 0.087 12.1 0.7 0.098 11.9 0.7 1.0 1 0 0 1 1 1 0 Baculoviral E56 protein, specific to ODV envelope zf-CCHC PF00098.23 EMD58188.1 - 5.2e-07 29.4 4.0 1.5e-05 24.9 1.2 3.4 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_2 PF13696.6 EMD58188.1 - 0.00017 21.3 0.8 0.00066 19.5 0.8 2.1 1 0 0 1 1 1 1 Zinc knuckle WCCH PF03716.14 EMD58188.1 - 0.024 14.3 0.1 0.024 14.3 0.1 4.0 4 0 0 4 4 4 0 WCCH motif Zn_clus PF00172.18 EMD58191.1 - 9.1e-05 22.5 4.1 0.00014 21.9 4.1 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF2072 PF09845.9 EMD58191.1 - 0.0077 16.5 2.1 0.01 16.1 2.1 1.1 1 0 0 1 1 1 1 Zn-ribbon containing protein HYLS1_C PF15311.6 EMD58192.1 - 0.0031 18.2 0.0 0.0034 18.1 0.0 1.0 1 0 0 1 1 1 1 Hydrolethalus syndrome protein 1 C-terminus zf-CRD PF17979.1 EMD58193.1 - 0.11 12.6 0.0 0.13 12.3 0.0 1.1 1 0 0 1 1 1 0 Cysteine rich domain with multizinc binding regions HemY_N PF07219.13 EMD58195.1 - 0.25 11.6 2.6 0.27 11.5 2.6 1.1 1 0 0 1 1 1 0 HemY protein N-terminus Amastin PF07344.11 EMD58197.1 - 0.036 13.9 0.3 0.036 13.9 0.3 2.0 1 1 1 2 2 2 0 Amastin surface glycoprotein HTH_Tnp_Tc3_2 PF01498.18 EMD58198.1 - 1.7e-08 34.6 0.1 2.4e-08 34.1 0.1 1.3 1 0 0 1 1 1 1 Transposase Zn_clus PF00172.18 EMD58201.1 - 7.1e-10 38.9 13.4 1.9e-09 37.5 13.4 1.8 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain NblA PF04485.12 EMD58201.1 - 0.056 13.9 0.0 0.2 12.1 0.0 2.0 1 0 0 1 1 1 0 Phycobilisome degradation protein nblA DDE_1 PF03184.19 EMD58202.1 - 1.9e-10 40.7 0.0 2.7e-10 40.2 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease SL4P PF17618.2 EMD58202.1 - 0.019 15.0 0.0 0.032 14.3 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized Strongylid L4 protein DDE_3 PF13358.6 EMD58202.1 - 0.032 14.0 0.0 4.8 6.9 0.0 2.2 1 1 1 2 2 2 0 DDE superfamily endonuclease DDE_1 PF03184.19 EMD58203.1 - 2.3e-28 99.0 0.0 3.4e-28 98.5 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.6 EMD58203.1 - 1.3e-06 28.3 0.0 0.001 18.9 0.0 2.3 2 0 0 2 2 2 2 DDE superfamily endonuclease Condensation PF00668.20 EMD58205.1 - 5.9e-16 58.2 0.1 1.6e-15 56.8 0.1 1.6 1 1 0 1 1 1 1 Condensation domain PP-binding PF00550.25 EMD58206.1 - 4.4e-11 43.0 0.2 7.9e-11 42.2 0.2 1.4 1 0 0 1 1 1 1 Phosphopantetheine attachment site AMP-binding PF00501.28 EMD58206.1 - 1.8e-07 30.1 0.0 2.6e-07 29.6 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme DUF979 PF06166.12 EMD58208.1 - 0.012 14.8 0.2 0.014 14.6 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF979) HCMV_UL124 PF17609.2 EMD58208.1 - 0.065 13.4 1.9 0.082 13.1 1.9 1.2 1 0 0 1 1 1 0 Family of unknown function Dimer_Tnp_hAT PF05699.14 EMD58212.1 - 3.4e-18 65.2 0.1 3.7e-18 65.1 0.1 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Condensation PF00668.20 EMD58213.1 - 5.7e-193 641.7 0.0 2.8e-47 161.5 0.0 5.6 5 0 0 5 5 5 5 Condensation domain AMP-binding PF00501.28 EMD58213.1 - 1.4e-159 531.2 0.0 3.4e-70 236.8 0.0 3.2 3 0 0 3 3 3 3 AMP-binding enzyme PP-binding PF00550.25 EMD58213.1 - 2e-34 117.7 0.0 1.9e-08 34.6 0.1 6.1 5 0 0 5 5 5 4 Phosphopantetheine attachment site AMP-binding_C PF13193.6 EMD58213.1 - 3e-06 28.1 0.0 0.28 12.2 0.0 3.9 3 0 0 3 3 3 2 AMP-binding enzyme C-terminal domain AATase PF07247.12 EMD58213.1 - 0.0033 16.0 1.5 0.16 10.5 0.0 3.4 3 0 0 3 3 3 1 Alcohol acetyltransferase Viral_P18 PF04521.13 EMD58213.1 - 0.059 13.2 0.0 3.3 7.5 0.0 2.6 2 0 0 2 2 2 0 ssRNA positive strand viral 18kD cysteine rich protein DUF5122 PF17164.4 EMD58213.1 - 0.22 11.9 0.2 18 5.7 0.0 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF5122) beta-propeller AMP-binding PF00501.28 EMD58214.1 - 5.6e-07 28.5 0.1 7.8e-07 28.0 0.1 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EMD58214.1 - 0.003 18.5 0.0 0.006 17.5 0.0 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain MCR_beta_N PF02783.15 EMD58214.1 - 0.0078 15.8 0.0 0.01 15.5 0.0 1.3 1 0 0 1 1 1 1 Methyl-coenzyme M reductase beta subunit, N-terminal domain Cyclophil_like2 PF18050.1 EMD58214.1 - 0.036 14.0 0.0 0.059 13.3 0.0 1.3 1 0 0 1 1 1 0 Cyclophilin-like family PP-binding PF00550.25 EMD58215.1 - 2.5e-06 27.7 0.1 3.5e-06 27.3 0.1 1.2 1 0 0 1 1 1 1 Phosphopantetheine attachment site PNP_UDP_1 PF01048.20 EMD58218.1 - 4.5e-14 52.3 0.3 7.4e-14 51.6 0.3 1.3 1 0 0 1 1 1 1 Phosphorylase superfamily Ank_2 PF12796.7 EMD58218.1 - 1.2e-10 41.8 0.0 3e-08 34.1 0.0 3.4 3 0 0 3 3 3 1 Ankyrin repeats (3 copies) NACHT PF05729.12 EMD58218.1 - 3.3e-09 36.9 0.0 1.8e-08 34.5 0.0 2.2 2 1 0 2 2 2 1 NACHT domain Ank_4 PF13637.6 EMD58218.1 - 1.7e-08 34.8 0.1 7.9e-05 23.1 0.0 3.6 4 0 0 4 4 3 2 Ankyrin repeats (many copies) AAA_16 PF13191.6 EMD58218.1 - 2.6e-08 34.4 0.0 9.1e-08 32.7 0.0 1.9 1 0 0 1 1 1 1 AAA ATPase domain Ank_5 PF13857.6 EMD58218.1 - 2.8e-08 33.9 1.1 0.0037 17.5 0.0 3.8 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 EMD58218.1 - 9e-06 25.9 0.1 0.0051 17.2 0.0 3.8 4 0 0 4 4 4 1 Ankyrin repeat Ank_3 PF13606.6 EMD58218.1 - 5.2e-05 23.3 0.1 0.3 11.8 0.0 3.5 2 0 0 2 2 2 2 Ankyrin repeat ATPase_2 PF01637.18 EMD58218.1 - 0.00049 20.1 0.0 0.0018 18.3 0.0 1.9 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea KAP_NTPase PF07693.14 EMD58218.1 - 0.0081 15.4 0.1 0.16 11.2 0.0 2.4 1 1 1 2 2 2 1 KAP family P-loop domain DUF2075 PF09848.9 EMD58218.1 - 0.0095 15.2 0.0 0.015 14.6 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) DUF4129 PF13559.6 EMD58218.1 - 1 9.7 5.2 1.3 9.3 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4129) Ank_2 PF12796.7 EMD58219.1 - 2.8e-23 82.3 0.0 3.2e-15 56.5 0.0 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EMD58219.1 - 4.1e-23 81.1 0.3 2.2e-08 34.2 0.0 2.6 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 EMD58219.1 - 1e-21 77.0 2.5 1.9e-08 34.7 0.0 3.7 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 EMD58219.1 - 2.9e-19 68.6 1.6 1.2e-06 28.7 0.0 4.1 5 0 0 5 5 5 3 Ankyrin repeat Ank_3 PF13606.6 EMD58219.1 - 8.5e-19 65.7 0.1 3.6e-05 23.8 0.0 3.8 4 0 0 4 4 4 3 Ankyrin repeat CSTF1_dimer PF16699.5 EMD58219.1 - 0.068 12.9 0.6 10 6.0 0.0 2.9 2 1 1 3 3 3 0 Cleavage stimulation factor subunit 1, dimerisation domain Chal_sti_synt_C PF02797.15 EMD58219.1 - 0.11 12.5 0.4 1.8 8.5 0.1 2.1 1 1 1 2 2 2 0 Chalcone and stilbene synthases, C-terminal domain Trp_DMAT PF11991.8 EMD58220.1 - 3.6e-109 365.5 0.0 4.3e-109 365.3 0.0 1.1 1 0 0 1 1 1 1 Tryptophan dimethylallyltransferase Pyr_redox_2 PF07992.14 EMD58221.1 - 3e-06 26.7 0.1 0.0095 15.2 0.0 2.7 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 EMD58221.1 - 3.3e-05 22.5 0.0 0.00028 19.4 0.0 2.0 2 0 0 2 2 2 1 Flavin-binding monooxygenase-like 2-Hacid_dh_C PF02826.19 EMD58221.1 - 0.012 15.0 0.0 0.024 14.0 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 EMD58221.1 - 0.023 14.8 0.0 0.077 13.1 0.0 1.8 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase NAD_binding_8 PF13450.6 EMD58221.1 - 0.047 13.9 0.1 0.27 11.5 0.1 2.1 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 EMD58221.1 - 0.095 11.9 0.0 0.98 8.6 0.0 2.4 2 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase WD40 PF00400.32 EMD58222.1 - 1.6e-137 443.3 33.6 2e-10 41.1 0.3 14.2 13 1 0 13 13 13 13 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD58222.1 - 1.2e-51 172.9 0.6 0.0001 22.5 0.0 12.7 1 1 9 11 11 11 10 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EMD58222.1 - 3.2e-26 92.1 12.1 0.2 10.6 0.0 12.7 1 1 11 12 12 12 9 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 EMD58222.1 - 1.3e-22 79.1 1.1 0.34 10.9 0.0 13.1 14 0 0 14 14 14 2 WD40-like Beta Propeller Repeat Nup160 PF11715.8 EMD58222.1 - 9.3e-19 67.5 23.7 0.031 12.9 0.3 11.6 2 2 10 12 12 12 5 Nucleoporin Nup120/160 eIF2A PF08662.11 EMD58222.1 - 3.9e-16 59.5 0.0 0.089 12.7 0.0 5.9 1 1 4 6 6 6 5 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 EMD58222.1 - 1.7e-14 53.9 0.0 1.2 8.4 0.0 8.2 5 3 3 8 8 8 5 WD40-like domain Ret2_MD PF18528.1 EMD58222.1 - 1.1e-13 51.4 4.9 2.8 8.4 0.0 11.2 3 2 10 13 13 11 1 RNA editing 3' terminal uridylyl transferase 2 middle domain Proteasome_A_N PF10584.9 EMD58222.1 - 1.3e-13 50.3 0.2 7.4 6.3 0.0 10.9 11 0 0 11 11 11 0 Proteasome subunit A N-terminal signature DUF1513 PF07433.11 EMD58222.1 - 9.9e-13 47.8 18.9 0.007 15.5 0.2 7.3 1 1 6 7 7 7 6 Protein of unknown function (DUF1513) AAA_16 PF13191.6 EMD58222.1 - 7e-10 39.5 3.4 1.3e-06 28.9 0.1 3.7 3 0 0 3 3 3 1 AAA ATPase domain IKI3 PF04762.12 EMD58222.1 - 8.5e-08 30.7 4.4 0.51 8.3 0.0 5.8 1 1 4 6 6 6 3 IKI3 family NACHT PF05729.12 EMD58222.1 - 2.5e-07 30.7 0.0 6.1e-07 29.5 0.0 1.6 1 0 0 1 1 1 1 NACHT domain DUF4189 PF13827.6 EMD58222.1 - 1.3e-05 25.7 7.5 6.4 7.4 0.1 7.1 2 2 5 7 7 7 0 Domain of unknown function (DUF4189) Helo_like_N PF17111.5 EMD58222.1 - 1.4e-05 24.6 0.3 2.6e-05 23.7 0.3 1.4 1 0 0 1 1 1 1 Fungal N-terminal domain of STAND proteins TruB_C PF09142.11 EMD58222.1 - 4.9e-05 23.0 4.4 1.6e+02 2.2 0.0 9.2 10 0 0 10 10 10 0 tRNA Pseudouridine synthase II, C terminal Defensin_RK-1 PF17860.1 EMD58222.1 - 0.0002 21.8 8.2 4.2e+02 1.5 0.0 10.0 12 0 0 12 12 11 0 RK-1-like defensin NB-ARC PF00931.22 EMD58222.1 - 0.0023 17.2 0.0 0.0045 16.2 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain AAA PF00004.29 EMD58222.1 - 0.0024 18.3 0.0 0.0077 16.7 0.0 1.9 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EMD58222.1 - 0.0063 16.8 0.8 0.066 13.5 0.0 2.7 3 0 0 3 3 2 1 AAA domain PIF1 PF05970.14 EMD58222.1 - 0.0076 15.5 0.0 0.012 14.8 0.0 1.3 1 0 0 1 1 1 1 PIF1-like helicase APS_kinase PF01583.20 EMD58222.1 - 0.029 14.3 0.1 0.056 13.3 0.1 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase PhoH PF02562.16 EMD58222.1 - 0.032 13.7 0.0 4.4 6.7 0.0 2.4 2 0 0 2 2 2 0 PhoH-like protein RAB3GAP2_N PF14655.6 EMD58222.1 - 0.034 13.4 0.1 62 2.7 0.0 5.1 5 2 1 6 6 6 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Cytochrom_D1 PF02239.16 EMD58222.1 - 0.038 12.5 2.1 5 5.5 0.0 4.2 2 1 4 6 6 6 0 Cytochrome D1 heme domain AAA_18 PF13238.6 EMD58222.1 - 0.041 14.4 0.0 0.45 11.1 0.0 2.6 3 0 0 3 3 2 0 AAA domain AAA_30 PF13604.6 EMD58222.1 - 0.059 13.1 0.1 0.17 11.6 0.1 1.7 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EMD58222.1 - 0.089 12.5 0.1 0.5 10.0 0.0 2.1 2 0 0 2 2 2 0 AAA domain DUF3761 PF12587.8 EMD58222.1 - 0.1 13.0 6.8 81 3.8 0.0 6.5 5 1 2 8 8 8 0 Protein of unknown function (DUF3761) RNA_helicase PF00910.22 EMD58222.1 - 0.16 12.4 0.1 0.59 10.5 0.0 1.9 2 0 0 2 2 2 0 RNA helicase SurE PF01975.17 EMD58222.1 - 0.17 11.6 19.3 19 5.0 0.1 8.0 1 1 6 10 10 9 0 Survival protein SurE Peptidase_S9_N PF02897.15 EMD58222.1 - 0.22 10.3 0.5 7.9 5.2 0.0 4.0 6 0 0 6 6 6 0 Prolyl oligopeptidase, N-terminal beta-propeller domain DDE_3 PF13358.6 EMD58223.1 - 8.3e-08 32.1 0.0 1.4e-07 31.3 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease TPR_10 PF13374.6 EMD58224.1 - 2.7e-63 208.3 2.6 5.8e-12 45.1 0.0 6.0 5 1 0 5 5 5 5 Tetratricopeptide repeat TPR_12 PF13424.6 EMD58224.1 - 6.1e-42 141.8 0.4 4.5e-12 46.1 0.0 5.8 1 1 4 5 5 5 5 Tetratricopeptide repeat TPR_7 PF13176.6 EMD58224.1 - 2.9e-18 64.5 1.9 0.006 16.5 0.0 6.1 5 0 0 5 5 5 4 Tetratricopeptide repeat NB-ARC PF00931.22 EMD58224.1 - 1.5e-13 50.5 0.0 2.8e-13 49.7 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain HET PF06985.11 EMD58224.1 - 5.9e-11 42.9 12.7 1e-08 35.7 5.5 3.4 2 1 1 3 3 2 2 Heterokaryon incompatibility protein (HET) TPR_2 PF07719.17 EMD58224.1 - 2.3e-10 39.8 1.2 1.2 9.4 0.0 6.3 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_4 PF07721.14 EMD58224.1 - 2.4e-09 36.9 0.1 0.57 11.0 0.1 6.1 5 0 0 5 5 5 1 Tetratricopeptide repeat AAA_16 PF13191.6 EMD58224.1 - 2e-08 34.8 0.3 2e-08 34.8 0.3 2.8 2 1 0 2 2 2 1 AAA ATPase domain TPR_17 PF13431.6 EMD58224.1 - 3.3e-06 27.1 2.6 5.9 7.5 0.0 5.8 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_8 PF13181.6 EMD58224.1 - 4.4e-06 26.5 1.5 1.2 9.5 0.0 5.8 6 0 0 6 6 5 1 Tetratricopeptide repeat AAA_22 PF13401.6 EMD58224.1 - 4.7e-06 26.9 0.2 1.8e-05 25.1 0.0 2.1 2 0 0 2 2 1 1 AAA domain AAA PF00004.29 EMD58224.1 - 0.00011 22.6 0.0 0.00049 20.5 0.0 2.2 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 EMD58224.1 - 0.00013 21.9 0.1 0.00034 20.6 0.1 1.8 1 0 0 1 1 1 1 NACHT domain TPR_19 PF14559.6 EMD58224.1 - 0.00013 22.4 0.0 0.22 12.0 0.0 4.2 4 1 1 5 5 4 1 Tetratricopeptide repeat TPR_1 PF00515.28 EMD58224.1 - 0.00022 20.9 0.5 15 5.6 0.0 5.5 6 0 0 6 6 6 0 Tetratricopeptide repeat TniB PF05621.11 EMD58224.1 - 0.00022 20.7 0.0 0.00058 19.3 0.0 1.6 1 0 0 1 1 1 1 Bacterial TniB protein ATPase_2 PF01637.18 EMD58224.1 - 0.00051 20.0 0.0 0.0012 18.8 0.0 1.7 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea TPR_MalT PF17874.1 EMD58224.1 - 0.00067 19.1 2.5 0.00067 19.1 2.5 2.5 1 1 1 2 2 2 1 MalT-like TPR region TPR_16 PF13432.6 EMD58224.1 - 0.0012 19.4 0.0 13 6.5 0.0 4.8 4 1 0 4 4 3 0 Tetratricopeptide repeat IstB_IS21 PF01695.17 EMD58224.1 - 0.0021 17.8 0.0 0.0092 15.7 0.0 2.1 2 0 0 2 2 2 1 IstB-like ATP binding protein DnaB_C PF03796.15 EMD58224.1 - 0.022 14.1 0.0 0.046 13.0 0.0 1.5 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain Sigma54_activ_2 PF14532.6 EMD58224.1 - 0.028 14.5 1.1 0.75 9.9 0.3 3.0 2 1 0 2 2 2 0 Sigma-54 interaction domain STD1 PF17235.2 EMD58224.1 - 0.046 13.4 0.6 0.34 10.5 0.1 2.6 2 0 0 2 2 2 0 STD1/MTH1 AnkUBD PF18418.1 EMD58224.1 - 0.075 13.2 0.1 0.21 11.8 0.1 1.7 1 0 0 1 1 1 0 Ankyrin ubiquitin-binding domain SRP54 PF00448.22 EMD58224.1 - 0.075 12.7 0.1 0.42 10.2 0.0 2.2 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain MF_alpha_N PF05436.11 EMD58225.1 - 0.017 15.0 0.1 0.022 14.7 0.1 1.1 1 0 0 1 1 1 0 Mating factor alpha precursor N-terminus DDE_1 PF03184.19 EMD58226.1 - 9.4e-09 35.2 0.0 1e-08 35.0 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease ATP_transf PF09830.9 EMD58227.1 - 1.1e-10 41.4 0.0 2e-10 40.6 0.0 1.4 1 0 0 1 1 1 1 ATP adenylyltransferase DUF4922 PF16269.5 EMD58227.1 - 0.045 13.5 0.1 0.079 12.7 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4922) WD40 PF00400.32 EMD58228.1 - 3.5e-106 344.1 77.7 1.3e-10 41.7 0.6 12.9 12 1 0 12 12 11 11 WD domain, G-beta repeat NACHT_N PF17100.5 EMD58228.1 - 2.6e-80 269.4 7.9 2.6e-80 269.4 7.9 1.7 2 0 0 2 2 2 1 N-terminal domain of NWD NACHT-NTPase ANAPC4_WD40 PF12894.7 EMD58228.1 - 1.8e-48 162.7 21.2 0.00011 22.4 0.0 12.0 2 1 10 12 12 12 11 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EMD58228.1 - 1.4e-21 76.8 30.0 0.18 10.4 0.1 11.2 1 1 10 11 11 11 11 Nucleoporin Nup120/160 NACHT PF05729.12 EMD58228.1 - 4.4e-18 65.7 0.2 9.1e-18 64.7 0.2 1.5 1 0 0 1 1 1 1 NACHT domain Ge1_WD40 PF16529.5 EMD58228.1 - 1.8e-12 46.9 31.3 0.0046 16.0 1.6 8.0 1 1 5 6 6 6 6 WD40 region of Ge1, enhancer of mRNA-decapping protein Nbas_N PF15492.6 EMD58228.1 - 2.8e-11 43.3 26.8 0.5 9.7 0.1 9.9 2 2 9 11 11 11 7 Neuroblastoma-amplified sequence, N terminal CDtoxinA PF03498.14 EMD58228.1 - 1.5e-10 40.8 0.1 2.8 7.5 0.0 7.4 2 2 4 6 6 6 3 Cytolethal distending toxin A/C domain Asp_decarbox PF02261.16 EMD58228.1 - 4.9e-06 26.5 0.0 77 3.3 0.0 7.7 3 2 6 9 9 9 0 Aspartate decarboxylase WD40_like PF17005.5 EMD58228.1 - 9.2e-06 25.2 4.0 23 4.2 0.0 7.1 4 1 4 8 8 8 0 WD40-like domain AAA_19 PF13245.6 EMD58228.1 - 0.14 12.5 0.0 0.37 11.1 0.0 1.7 1 1 0 1 1 1 0 AAA domain TPR_12 PF13424.6 EMD58229.1 - 2.9e-18 65.9 0.5 7.3e-12 45.4 0.1 2.0 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 EMD58229.1 - 7e-17 60.7 0.8 2.4e-09 36.7 0.1 2.1 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 EMD58229.1 - 5.3e-05 23.0 0.3 0.41 10.8 0.0 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 EMD58229.1 - 0.038 13.8 0.4 11 6.0 0.0 2.7 2 1 1 3 3 3 0 Tetratricopeptide repeat SBD_N PF07005.11 EMD58229.1 - 0.041 13.6 0.1 0.043 13.5 0.1 1.0 1 0 0 1 1 1 0 Sugar-binding N-terminal domain TPR_2 PF07719.17 EMD58229.1 - 0.05 13.7 0.8 0.96 9.7 0.0 2.4 2 1 0 2 2 2 0 Tetratricopeptide repeat zf-C2H2_jaz PF12171.8 EMD58230.1 - 6e-16 58.3 9.1 0.0046 17.2 0.1 4.5 4 0 0 4 4 4 4 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 EMD58230.1 - 1.6e-11 43.9 17.3 0.032 14.2 0.7 4.5 5 0 0 5 5 4 4 C2H2-type zinc finger zf-C2H2_2 PF12756.7 EMD58230.1 - 7.5e-10 39.1 15.5 0.014 15.7 0.3 4.3 2 1 3 5 5 4 4 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 EMD58230.1 - 4e-06 27.2 9.3 4.2 8.5 0.1 4.7 5 0 0 5 5 4 2 C2H2-type zinc finger zf-C2H2 PF00096.26 EMD58230.1 - 0.00013 22.2 17.6 2.6 8.7 0.2 4.7 5 0 0 5 5 4 4 Zinc finger, C2H2 type zf-C2HC_2 PF13913.6 EMD58230.1 - 0.00019 21.3 7.1 4.2 7.4 0.1 4.2 4 0 0 4 4 4 3 zinc-finger of a C2HC-type Lipoprotein_15 PF03640.15 EMD58230.1 - 0.00043 19.8 2.0 6.7 6.4 0.1 4.2 4 0 0 4 4 4 2 Secreted repeat of unknown function zf-met PF12874.7 EMD58230.1 - 0.0011 19.3 15.7 4.2 7.9 0.2 4.7 5 0 0 5 5 4 2 Zinc-finger of C2H2 type DUF4428 PF14471.6 EMD58230.1 - 0.0015 18.4 9.9 7.3 6.6 0.1 4.3 4 0 0 4 4 4 2 Domain of unknown function (DUF4428) zf-H2C2_2 PF13465.6 EMD58230.1 - 0.0033 17.8 18.9 5.3 7.7 0.1 4.4 4 0 0 4 4 4 4 Zinc-finger double domain TF_Zn_Ribbon PF08271.12 EMD58230.1 - 0.013 15.0 2.5 49 3.5 0.0 4.0 4 0 0 4 4 4 0 TFIIB zinc-binding DUF983 PF06170.12 EMD58230.1 - 0.34 11.4 5.7 1.5e+02 2.9 0.1 3.9 4 0 0 4 4 4 0 Protein of unknown function (DUF983) Zf_RING PF16744.5 EMD58230.1 - 0.46 10.6 7.5 41 4.4 0.1 4.0 1 1 3 4 4 4 0 KIAA1045 RING finger DUF281 PF03436.13 EMD58230.1 - 0.48 10.9 7.5 6.2 7.3 0.7 3.4 1 1 3 4 4 4 0 Domain of unknown function (DUF281) HNH_5 PF14279.6 EMD58230.1 - 0.69 9.8 10.0 1.3 9.0 0.8 3.5 1 1 2 3 3 3 0 HNH endonuclease APOBEC3 PF18771.1 EMD58230.1 - 1.8 8.7 5.9 72 3.5 0.1 3.5 4 0 0 4 4 4 0 APOBEC3 zf-AN1 PF01428.16 EMD58230.1 - 2.1 8.6 10.6 75 3.6 0.2 4.2 4 0 0 4 4 4 0 AN1-like Zinc finger zinc-ribbons_6 PF07191.12 EMD58230.1 - 5.2 7.1 12.7 21 5.2 0.3 3.2 1 1 2 3 3 3 0 zinc-ribbons C1_4 PF07975.12 EMD58230.1 - 6.1 7.2 11.6 30 4.9 2.1 3.0 1 1 3 4 4 4 0 TFIIH C1-like domain zinc_ribbon_4 PF13717.6 EMD58230.1 - 9.4 6.3 14.3 31 4.6 0.2 4.1 4 0 0 4 4 4 0 zinc-ribbon domain Abhydrolase_6 PF12697.7 EMD58231.1 - 0.00027 21.6 0.0 0.00033 21.3 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EMD58231.1 - 0.0042 16.4 0.1 0.0082 15.4 0.0 1.5 2 0 0 2 2 2 1 Serine aminopeptidase, S33 DUF676 PF05057.14 EMD58231.1 - 0.03 13.8 0.0 0.043 13.3 0.0 1.4 1 1 0 1 1 1 0 Putative serine esterase (DUF676) TPR_10 PF13374.6 EMD58233.1 - 3.5e-81 265.1 31.8 8.6e-10 38.2 0.2 11.6 11 0 0 11 11 11 10 Tetratricopeptide repeat TPR_12 PF13424.6 EMD58233.1 - 1.7e-75 249.3 62.7 4.2e-17 62.2 2.2 8.4 4 2 5 9 9 8 8 Tetratricopeptide repeat TPR_1 PF00515.28 EMD58233.1 - 4.8e-42 140.1 43.1 4.6e-05 23.1 0.2 11.4 11 1 0 11 11 11 7 Tetratricopeptide repeat TPR_8 PF13181.6 EMD58233.1 - 2.5e-29 99.0 31.1 0.0047 17.0 0.3 10.8 11 0 0 11 11 11 7 Tetratricopeptide repeat TPR_7 PF13176.6 EMD58233.1 - 2.4e-28 96.0 48.1 0.002 18.0 0.1 11.2 11 0 0 11 11 11 7 Tetratricopeptide repeat TPR_2 PF07719.17 EMD58233.1 - 2.1e-27 93.0 40.8 0.0092 16.0 0.4 10.9 11 0 0 11 11 11 7 Tetratricopeptide repeat TPR_MalT PF17874.1 EMD58233.1 - 8.9e-19 68.0 30.4 6.6e-08 32.3 3.7 4.7 1 1 3 4 4 4 4 MalT-like TPR region TPR_16 PF13432.6 EMD58233.1 - 1.6e-15 57.5 51.4 0.09 13.4 0.4 11.2 11 1 1 12 12 11 7 Tetratricopeptide repeat TPR_17 PF13431.6 EMD58233.1 - 2e-12 46.5 20.8 3.9 8.1 0.1 9.5 7 1 1 8 8 8 4 Tetratricopeptide repeat TPR_4 PF07721.14 EMD58233.1 - 3.1e-12 45.9 5.1 1.8 9.4 0.0 8.8 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_14 PF13428.6 EMD58233.1 - 1.2e-11 44.3 29.4 2.5 9.1 0.0 11.2 11 1 1 12 12 9 1 Tetratricopeptide repeat DUF2225 PF09986.9 EMD58233.1 - 8.7e-10 38.7 17.3 0.028 14.1 0.3 6.2 1 1 7 8 8 8 5 Uncharacterized protein conserved in bacteria (DUF2225) AAA_16 PF13191.6 EMD58233.1 - 5.9e-09 36.5 0.4 2.4e-08 34.5 0.1 2.2 2 0 0 2 2 2 1 AAA ATPase domain NB-ARC PF00931.22 EMD58233.1 - 5.2e-07 29.1 0.1 4.4e-06 26.1 0.0 2.2 1 1 1 2 2 2 1 NB-ARC domain DUF4810 PF16068.5 EMD58233.1 - 0.00025 21.5 22.0 29 5.3 0.1 8.5 8 0 0 8 8 8 0 Domain of unknown function (DUF4810) TPR_3 PF07720.12 EMD58233.1 - 0.00055 19.9 32.0 2.2 8.4 0.3 9.3 9 1 1 10 10 9 2 Tetratricopeptide repeat TPR_11 PF13414.6 EMD58233.1 - 0.0014 18.3 35.8 4.3 7.1 0.4 9.3 9 0 0 9 9 9 2 TPR repeat RPN7 PF10602.9 EMD58233.1 - 0.0031 17.3 10.0 24 4.6 0.0 6.6 2 2 5 7 7 7 0 26S proteasome subunit RPN7 TniB PF05621.11 EMD58233.1 - 0.005 16.3 0.0 0.042 13.3 0.0 2.6 3 0 0 3 3 3 1 Bacterial TniB protein ATPase_2 PF01637.18 EMD58233.1 - 0.0051 16.8 0.0 0.0095 15.9 0.0 1.4 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_22 PF13401.6 EMD58233.1 - 0.0058 16.9 0.0 0.033 14.5 0.0 2.3 2 0 0 2 2 1 1 AAA domain DUF3512 PF12024.8 EMD58233.1 - 0.0077 15.7 0.2 0.11 11.9 0.0 2.7 3 0 0 3 3 3 1 Domain of unknown function (DUF3512) Wzy_C_2 PF11846.8 EMD58233.1 - 0.017 15.1 21.1 8.8 6.2 0.1 7.5 3 2 3 7 7 7 0 Virulence factor membrane-bound polymerase, C-terminal rve_3 PF13683.6 EMD58233.1 - 0.03 14.1 0.0 6.2 6.7 0.1 3.1 2 0 0 2 2 2 0 Integrase core domain NACHT PF05729.12 EMD58233.1 - 0.038 13.9 0.1 0.1 12.5 0.1 1.7 1 1 0 1 1 1 0 NACHT domain TPR_6 PF13174.6 EMD58233.1 - 3.1 8.6 41.7 13 6.7 0.2 9.4 8 0 0 8 8 8 0 Tetratricopeptide repeat DUF1889 PF08986.10 EMD58237.1 - 0.02 15.3 0.0 0.024 15.1 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1889) DUF3632 PF12311.8 EMD58238.1 - 4.2e-20 72.9 0.1 5.6e-20 72.5 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3632) HTH_psq PF05225.16 EMD58239.1 - 0.0002 21.0 0.2 0.00028 20.6 0.2 1.3 1 0 0 1 1 1 1 helix-turn-helix, Psq domain CENP-B_N PF04218.13 EMD58239.1 - 0.027 14.1 0.2 0.038 13.6 0.2 1.3 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain BrkDBD PF09607.10 EMD58239.1 - 0.079 12.7 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 Brinker DNA-binding domain Condensation PF00668.20 EMD58240.1 - 1.1e-77 261.6 0.0 4.7e-45 154.1 0.0 2.2 2 0 0 2 2 2 2 Condensation domain AMP-binding PF00501.28 EMD58240.1 - 1e-74 251.6 2.7 1.2e-53 182.3 2.9 2.4 2 0 0 2 2 2 2 AMP-binding enzyme PP-binding PF00550.25 EMD58240.1 - 4.3e-13 49.4 0.0 1.3e-12 47.8 0.0 2.0 1 0 0 1 1 1 1 Phosphopantetheine attachment site AMP-binding_C PF13193.6 EMD58240.1 - 0.011 16.7 0.0 0.029 15.3 0.0 1.9 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain AMP-binding PF00501.28 EMD58241.1 - 1.7e-33 115.9 0.5 1.9e-33 115.7 0.5 1.0 1 0 0 1 1 1 1 AMP-binding enzyme ASC PF00858.24 EMD58241.1 - 0.022 13.8 0.0 0.022 13.7 0.0 1.1 1 0 0 1 1 1 0 Amiloride-sensitive sodium channel Condensation PF00668.20 EMD58242.1 - 6.4e-40 137.2 0.0 1.3e-39 136.2 0.0 1.5 1 1 0 1 1 1 1 Condensation domain DnaG_DnaB_bind PF08278.11 EMD58242.1 - 0.05 14.2 2.2 9.5 6.8 0.3 3.0 2 1 0 2 2 2 0 DNA primase DnaG DnaB-binding AMP-binding PF00501.28 EMD58243.1 - 2.1e-114 382.4 0.2 5.6e-75 252.5 0.0 2.5 2 0 0 2 2 2 2 AMP-binding enzyme Condensation PF00668.20 EMD58243.1 - 2.8e-89 299.9 0.1 4.1e-89 299.4 0.1 1.2 1 0 0 1 1 1 1 Condensation domain PP-binding PF00550.25 EMD58243.1 - 3.8e-31 107.2 0.1 6.3e-14 52.1 0.0 3.2 3 0 0 3 3 3 2 Phosphopantetheine attachment site AMP-binding_C PF13193.6 EMD58243.1 - 4.4e-12 46.8 0.6 0.0043 18.0 0.0 4.2 3 0 0 3 3 3 3 AMP-binding enzyme C-terminal domain Methyltransf_23 PF13489.6 EMD58243.1 - 2e-06 27.8 0.0 2.7e-05 24.0 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMD58243.1 - 2.8e-05 24.7 0.0 0.00011 22.8 0.0 2.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMD58243.1 - 0.0012 19.5 0.0 0.0039 17.9 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMD58243.1 - 0.0059 17.2 0.0 0.02 15.5 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMD58243.1 - 0.067 13.0 0.0 0.15 11.8 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain CHASE3 PF05227.13 EMD58243.1 - 0.23 11.4 1.5 0.49 10.3 0.1 2.3 2 0 0 2 2 2 0 CHASE3 domain Creb_binding PF09030.10 EMD58243.1 - 4.9 7.9 8.6 16 6.3 8.6 1.8 1 0 0 1 1 1 0 Creb binding Condensation PF00668.20 EMD58244.1 - 8.3e-41 140.1 0.0 1.4e-40 139.3 0.0 1.3 1 0 0 1 1 1 1 Condensation domain Trp_DMAT PF11991.8 EMD58245.1 - 4.3e-102 342.2 0.0 5.1e-102 342.0 0.0 1.1 1 0 0 1 1 1 1 Tryptophan dimethylallyltransferase Ank_5 PF13857.6 EMD58246.1 - 3.4e-08 33.6 0.0 0.00058 20.1 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EMD58246.1 - 8.4e-07 29.5 0.0 0.00046 20.7 0.0 2.0 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMD58246.1 - 3e-05 24.5 0.0 0.015 15.9 0.0 3.4 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 EMD58246.1 - 3.5e-05 24.1 0.0 0.44 11.1 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeat NACHT PF05729.12 EMD58246.1 - 0.0013 18.7 0.0 0.0024 17.8 0.0 1.4 1 0 0 1 1 1 1 NACHT domain DDE_1 PF03184.19 EMD58248.1 - 8.7e-16 58.1 0.0 1.1e-15 57.7 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease WD40 PF00400.32 EMD58249.1 - 4.9e-57 188.6 26.1 1.4e-10 41.6 0.3 7.0 6 0 0 6 6 6 6 WD domain, G-beta repeat NACHT PF05729.12 EMD58249.1 - 2.3e-29 102.5 0.1 1e-28 100.4 0.1 2.0 2 0 0 2 2 2 1 NACHT domain ANAPC4_WD40 PF12894.7 EMD58249.1 - 1.9e-16 60.1 8.0 0.003 17.8 0.1 6.3 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain HET PF06985.11 EMD58249.1 - 8e-11 42.5 6.6 2.3e-08 34.5 0.2 3.3 2 1 1 3 3 3 2 Heterokaryon incompatibility protein (HET) Ge1_WD40 PF16529.5 EMD58249.1 - 1.3e-08 34.1 13.4 0.015 14.2 0.1 5.6 1 1 3 4 4 4 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 EMD58249.1 - 1.1e-05 24.3 21.1 0.14 10.8 0.4 5.8 1 1 5 6 6 6 4 Nucleoporin Nup120/160 CDtoxinA PF03498.14 EMD58249.1 - 0.00033 20.3 0.0 0.018 14.7 0.1 2.7 2 0 0 2 2 2 1 Cytolethal distending toxin A/C domain SAND PF01342.21 EMD58249.1 - 0.064 13.0 1.2 3.1 7.5 0.2 3.4 1 1 1 2 2 2 0 SAND domain Asp_decarbox PF02261.16 EMD58249.1 - 0.073 13.0 0.0 1.1e+02 2.8 0.0 4.0 2 1 2 4 4 4 0 Aspartate decarboxylase Cytochrom_D1 PF02239.16 EMD58249.1 - 0.097 11.2 0.9 9.6 4.6 0.0 2.5 1 1 1 2 2 2 0 Cytochrome D1 heme domain WD40 PF00400.32 EMD58250.1 - 6.5e-127 409.7 79.6 2.5e-10 40.7 1.9 13.8 13 0 0 13 13 13 13 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD58250.1 - 2e-41 140.2 27.7 0.00019 21.6 0.0 13.1 1 1 12 13 13 13 13 Anaphase-promoting complex subunit 4 WD40 domain NACHT PF05729.12 EMD58250.1 - 7.2e-24 84.6 0.1 2.5e-23 82.8 0.1 1.9 2 0 0 2 2 2 1 NACHT domain Nup160 PF11715.8 EMD58250.1 - 2.1e-20 72.9 44.9 0.0073 15.0 0.3 12.6 2 1 9 12 12 12 9 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 EMD58250.1 - 3.3e-20 72.3 43.1 3.5e-05 22.9 2.8 10.2 1 1 8 9 9 9 8 WD40 region of Ge1, enhancer of mRNA-decapping protein CDtoxinA PF03498.14 EMD58250.1 - 1.1e-09 38.1 4.8 1.1 8.8 0.0 7.3 2 2 7 9 9 9 5 Cytolethal distending toxin A/C domain HET PF06985.11 EMD58250.1 - 8.1e-09 36.0 0.1 8.1e-09 36.0 0.1 3.5 3 1 1 4 4 3 2 Heterokaryon incompatibility protein (HET) Asp_decarbox PF02261.16 EMD58250.1 - 4.4e-06 26.6 0.1 6.7 6.7 0.0 7.4 3 2 4 9 9 9 1 Aspartate decarboxylase DUF1513 PF07433.11 EMD58250.1 - 8.8e-06 25.0 21.5 1.6 7.8 0.0 8.2 1 1 10 11 11 11 4 Protein of unknown function (DUF1513) WD40_like PF17005.5 EMD58250.1 - 2.8e-05 23.6 4.7 0.91 8.8 0.0 5.3 3 2 1 6 6 6 2 WD40-like domain Amidohydro_3 PF07969.11 EMD58250.1 - 0.0008 19.0 0.1 1.5 8.2 0.0 3.3 2 1 1 3 3 3 2 Amidohydrolase family AAA_19 PF13245.6 EMD58250.1 - 0.15 12.4 0.0 0.35 11.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain Cytochrom_D1 PF02239.16 EMD58250.1 - 0.2 10.2 7.2 6.1 5.3 0.1 3.9 2 1 3 5 5 5 0 Cytochrome D1 heme domain p450 PF00067.22 EMD58252.1 - 6.1e-74 249.4 0.0 7.6e-74 249.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 NLPC_P60 PF00877.19 EMD58253.1 - 2.4e-10 40.4 0.5 3.8e-10 39.7 0.5 1.3 1 0 0 1 1 1 1 NlpC/P60 family CHAP PF05257.16 EMD58253.1 - 0.012 16.2 0.1 0.012 16.2 0.1 1.7 2 0 0 2 2 2 0 CHAP domain AA_permease PF00324.21 EMD58255.1 - 1.9e-16 59.7 19.0 4e-16 58.7 19.0 1.4 1 1 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EMD58255.1 - 1.1e-11 44.3 14.9 1.7e-11 43.6 14.9 1.3 1 0 0 1 1 1 1 Amino acid permease CorA PF01544.18 EMD58257.1 - 5.5e-05 22.6 4.4 8.5e-05 22.0 4.4 1.5 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein PRIMA1 PF16101.5 EMD58257.1 - 0.15 12.1 0.0 0.45 10.6 0.0 1.7 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 Peptidase_S8 PF00082.22 EMD58259.1 - 5.4e-14 52.1 0.0 1.4e-13 50.8 0.0 1.6 1 0 0 1 1 1 1 Subtilase family Ank_2 PF12796.7 EMD58259.1 - 5.8e-09 36.4 2.7 0.00075 20.0 0.6 2.8 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMD58259.1 - 0.00084 19.9 0.1 1.1 9.9 0.1 4.4 3 1 1 4 4 4 1 Ankyrin repeats (many copies) Ank PF00023.30 EMD58259.1 - 0.0072 16.7 0.3 0.33 11.5 0.0 3.0 2 1 0 2 2 2 1 Ankyrin repeat tRNA-synt_His PF13393.6 EMD58259.1 - 0.027 13.8 0.1 0.053 12.8 0.1 1.4 1 0 0 1 1 1 0 Histidyl-tRNA synthetase Ank_3 PF13606.6 EMD58259.1 - 0.055 14.0 3.0 1.6 9.5 0.0 4.3 4 1 2 6 6 6 0 Ankyrin repeat Macin PF14865.6 EMD58259.1 - 0.071 13.7 0.1 0.2 12.2 0.1 1.7 1 0 0 1 1 1 0 Macin SPEG_u2 PF16650.5 EMD58261.1 - 0.0034 17.5 1.1 0.0061 16.7 1.1 1.4 1 0 0 1 1 1 1 Unstructured region on SPEG complex protein Ank_2 PF12796.7 EMD58262.1 - 1e-42 144.6 1.8 1.3e-13 51.3 0.0 3.5 3 0 0 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EMD58262.1 - 4.1e-34 116.2 8.1 1.9e-07 31.2 0.0 7.4 2 1 6 8 8 8 7 Ankyrin repeats (many copies) Ank_4 PF13637.6 EMD58262.1 - 2.2e-33 114.2 2.4 5e-09 36.5 0.0 6.3 4 2 2 6 6 6 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMD58262.1 - 5.8e-30 100.0 0.8 4.4e-05 23.6 0.0 8.6 9 0 0 9 9 9 6 Ankyrin repeat Ank PF00023.30 EMD58262.1 - 2.1e-27 94.3 8.8 0.00024 21.4 0.0 9.0 9 0 0 9 9 9 6 Ankyrin repeat p450 PF00067.22 EMD58263.1 - 2.5e-31 108.9 0.0 3.3e-31 108.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Transferase PF02458.15 EMD58264.1 - 4.7e-14 51.9 0.0 2.1e-13 49.7 0.0 1.8 1 1 0 1 1 1 1 Transferase family p450 PF00067.22 EMD58265.1 - 2.7e-58 197.8 0.0 3.3e-58 197.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Prenyltrans PF00432.21 EMD58266.1 - 0.0026 17.4 3.4 0.03 14.1 0.0 3.9 4 0 0 4 4 4 1 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_C PF13243.6 EMD58266.1 - 0.13 11.4 2.0 0.65 9.0 0.1 2.7 3 1 0 3 3 3 0 Squalene-hopene cyclase C-terminal domain Aldedh PF00171.22 EMD58267.1 - 4.2e-133 444.2 0.0 4.7e-133 444.1 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 EMD58267.1 - 0.031 13.3 0.0 0.047 12.7 0.0 1.2 1 0 0 1 1 1 0 Acyl-CoA reductase (LuxC) OmdA PF13376.6 EMD58267.1 - 0.084 12.9 0.3 4 7.5 0.0 2.6 2 0 0 2 2 2 0 Bacteriocin-protection, YdeI or OmpD-Associated Cupin_2 PF07883.11 EMD58268.1 - 1.7e-13 50.1 1.1 2.3e-13 49.6 1.1 1.2 1 0 0 1 1 1 1 Cupin domain Cupin_6 PF12852.7 EMD58268.1 - 8.6e-06 25.6 0.1 1.1e-05 25.3 0.1 1.1 1 0 0 1 1 1 1 Cupin Cupin_1 PF00190.22 EMD58268.1 - 0.00038 20.1 0.1 0.00049 19.7 0.1 1.1 1 0 0 1 1 1 1 Cupin AraC_binding PF02311.19 EMD58268.1 - 0.0069 16.3 0.5 0.0093 15.9 0.5 1.2 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_3 PF05899.12 EMD58268.1 - 0.018 14.7 0.1 0.031 14.0 0.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF861) DUF4437 PF14499.6 EMD58268.1 - 0.078 12.1 0.1 0.094 11.8 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4437) NADH_Oxid_Nqo15 PF11497.8 EMD58268.1 - 0.11 12.6 0.2 9 6.4 0.0 2.1 1 1 1 2 2 2 0 NADH-quinone oxidoreductase chain 15 p450 PF00067.22 EMD58269.1 - 2.2e-43 148.7 0.0 2.8e-43 148.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Methyltransf_16 PF10294.9 EMD58270.1 - 4.4e-15 55.8 0.0 7.2e-15 55.2 0.0 1.3 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_25 PF13649.6 EMD58270.1 - 0.015 16.0 0.0 0.032 14.9 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.14 EMD58270.1 - 0.016 14.7 0.0 0.05 13.2 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_12 PF08242.12 EMD58270.1 - 0.02 15.6 0.0 0.041 14.6 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 EMD58270.1 - 0.033 14.0 0.0 0.055 13.3 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain PSD2 PF07624.11 EMD58270.1 - 0.11 12.3 0.3 0.2 11.5 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1585) Glyco_hydro_43 PF04616.14 EMD58271.1 - 1.7e-13 50.6 2.0 2.6e-13 49.9 2.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 Pectate_lyase PF03211.13 EMD58272.1 - 2.4e-71 239.5 5.3 3.2e-71 239.1 5.3 1.1 1 0 0 1 1 1 1 Pectate lyase Utp11 PF03998.13 EMD58273.1 - 2.5e-66 224.1 35.5 4.8e-66 223.2 35.5 1.4 1 1 0 1 1 1 1 Utp11 protein DUF2250 PF10007.9 EMD58273.1 - 5.1 7.3 9.4 3 8.0 0.1 2.9 3 1 0 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2250) adh_short PF00106.25 EMD58274.1 - 1.6e-39 135.4 0.4 1.9e-39 135.2 0.4 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD58274.1 - 2.4e-32 112.4 0.1 3.1e-32 112.0 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD58274.1 - 2.2e-10 40.7 3.8 8.2e-10 38.9 3.6 2.0 1 1 0 1 1 1 1 KR domain AlaDh_PNT_C PF01262.21 EMD58274.1 - 0.0078 15.5 0.3 0.014 14.7 0.3 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain YjeF_N PF03853.15 EMD58274.1 - 0.059 13.2 0.1 0.6 10.0 0.1 2.1 2 0 0 2 2 2 0 YjeF-related protein N-terminus Cmc1 PF08583.10 EMD58275.1 - 2.1e-14 53.3 4.4 4.1e-14 52.4 4.4 1.6 1 1 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like COX17 PF05051.13 EMD58275.1 - 0.011 16.1 0.9 3.2 8.2 0.0 2.4 2 0 0 2 2 2 0 Cytochrome C oxidase copper chaperone (COX17) Selenoprotein_S PF06936.11 EMD58275.1 - 0.042 13.7 4.2 0.051 13.4 4.2 1.1 1 0 0 1 1 1 0 Selenoprotein S (SelS) DUF2773 PF10971.8 EMD58275.1 - 0.066 13.3 0.1 0.13 12.4 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2773) TFIID-31kDa PF02291.15 EMD58276.1 - 1.8e-43 147.5 0.0 2.3e-43 147.2 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit fn3 PF00041.21 EMD58277.1 - 1.8e-05 25.0 0.0 4.3e-05 23.8 0.0 1.7 1 0 0 1 1 1 1 Fibronectin type III domain LNS2 PF08235.13 EMD58278.1 - 7.8e-95 316.6 0.0 1.1e-94 316.1 0.0 1.2 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.14 EMD58278.1 - 1.1e-41 140.9 0.0 2.2e-41 139.9 0.0 1.5 1 0 0 1 1 1 1 lipin, N-terminal conserved region Acid_phosphat_B PF03767.14 EMD58278.1 - 0.008 15.8 0.3 0.074 12.6 0.0 2.5 3 0 0 3 3 3 1 HAD superfamily, subfamily IIIB (Acid phosphatase) FPN1 PF06963.12 EMD58279.1 - 8e-133 443.2 10.2 9.4e-133 442.9 10.2 1.0 1 0 0 1 1 1 1 Ferroportin1 (FPN1) AflR PF08493.10 EMD58280.1 - 2.2e-10 40.5 8.1 7.3e-10 38.8 8.1 1.9 1 1 0 1 1 1 1 Aflatoxin regulatory protein Zn_clus PF00172.18 EMD58280.1 - 8.6e-09 35.4 13.0 8.6e-09 35.4 13.0 2.1 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Glyco_hydro_18 PF00704.28 EMD58284.1 - 9.2e-54 183.3 0.3 1.1e-53 183.0 0.3 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Chitin_bind_1 PF00187.19 EMD58284.1 - 2.3e-07 31.1 32.1 1.5e-05 25.4 16.2 2.9 2 0 0 2 2 2 2 Chitin recognition protein Polyketide_cyc PF03364.20 EMD58285.1 - 0.059 13.6 0.5 0.16 12.2 0.1 1.8 2 0 0 2 2 2 0 Polyketide cyclase / dehydrase and lipid transport RhoGEF67_u1 PF16615.5 EMD58285.1 - 0.092 13.3 5.5 0.76 10.3 1.1 2.8 1 1 1 2 2 2 0 Unstructured region one on RhoGEF 6 and 7 PAN_1 PF00024.26 EMD58286.1 - 0.0037 17.2 4.2 0.59 10.1 0.3 3.2 3 0 0 3 3 3 2 PAN domain PAN_4 PF14295.6 EMD58286.1 - 0.049 13.5 3.9 0.14 12.1 0.4 2.8 2 0 0 2 2 2 0 PAN domain AAA_16 PF13191.6 EMD58287.1 - 1.3e-06 28.9 0.0 6.1e-06 26.7 0.0 2.1 1 1 0 1 1 1 1 AAA ATPase domain DUF2193 PF09959.9 EMD58287.1 - 0.027 12.9 0.0 0.039 12.4 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2193) Nnf1 PF03980.14 EMD58287.1 - 0.043 14.2 0.2 2.3 8.7 0.0 2.4 2 0 0 2 2 2 0 Nnf1 DUF815 PF05673.13 EMD58287.1 - 0.14 11.3 0.0 0.33 10.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) F-box-like PF12937.7 EMD58288.1 - 1e-13 50.9 0.9 1.9e-13 50.1 0.9 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EMD58288.1 - 5.2e-09 35.8 0.8 1.4e-08 34.4 0.8 1.7 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 EMD58288.1 - 0.16 11.9 0.0 0.39 10.6 0.0 1.7 1 0 0 1 1 1 0 F-box Reg_prop PF07494.11 EMD58288.1 - 0.17 12.2 1.2 6.5 7.4 0.3 3.1 2 0 0 2 2 2 0 Two component regulator propeller SKG6 PF08693.10 EMD58289.1 - 0.00019 20.8 0.1 0.00044 19.6 0.1 1.6 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Mid2 PF04478.12 EMD58289.1 - 0.00067 19.5 0.1 0.0012 18.7 0.1 1.4 1 0 0 1 1 1 1 Mid2 like cell wall stress sensor TMEM154 PF15102.6 EMD58289.1 - 0.17 11.8 0.7 1.9 8.4 0.7 2.2 1 1 0 1 1 1 0 TMEM154 protein family DUF3431 PF11913.8 EMD58290.1 - 2.3e-80 269.4 0.5 2.9e-80 269.1 0.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3431) Asp PF00026.23 EMD58291.1 - 5.9e-06 25.9 6.8 0.04 13.3 4.2 2.5 2 1 0 2 2 2 2 Eukaryotic aspartyl protease DUF4931 PF16285.5 EMD58291.1 - 0.081 12.2 0.1 0.4 9.9 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4931) Profilin PF00235.19 EMD58296.1 - 8.7e-42 142.4 0.5 9.6e-42 142.3 0.5 1.0 1 0 0 1 1 1 1 Profilin RRM_1 PF00076.22 EMD58297.1 - 2.6e-10 40.0 0.0 3.5e-10 39.6 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pkinase PF00069.25 EMD58298.1 - 2.6e-66 223.7 0.0 3.8e-66 223.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD58298.1 - 7.7e-30 104.0 0.5 1.2e-29 103.4 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 EMD58298.1 - 0.00018 21.5 4.1 0.00053 20.0 0.0 2.2 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 EMD58298.1 - 0.00018 20.9 0.0 0.00031 20.2 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 EMD58298.1 - 0.0037 16.9 0.1 0.0037 16.9 0.1 1.8 2 0 0 2 2 2 1 RIO1 family Haspin_kinase PF12330.8 EMD58298.1 - 0.004 16.2 0.0 0.007 15.4 0.0 1.4 1 1 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 EMD58298.1 - 0.0058 16.0 0.0 0.011 15.1 0.0 1.5 1 0 0 1 1 1 1 Kinase-like DUF1679 PF07914.11 EMD58298.1 - 0.064 12.1 0.1 0.51 9.1 0.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1679) BAF1_ABF1 PF04684.13 EMD58298.1 - 0.36 9.8 5.1 0.49 9.4 5.1 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Methyltransf_28 PF02636.17 EMD58299.1 - 1.2e-75 254.5 0.0 1.4e-75 254.3 0.0 1.1 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase PRMT5 PF05185.16 EMD58299.1 - 0.092 12.6 0.0 0.2 11.5 0.0 1.5 2 0 0 2 2 2 0 PRMT5 arginine-N-methyltransferase Anoctamin PF04547.12 EMD58300.1 - 7.3e-113 377.8 5.2 9.7e-113 377.4 5.2 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel PAP_assoc PF03828.19 EMD58301.1 - 5e-09 36.2 0.0 1e-08 35.2 0.0 1.6 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 EMD58301.1 - 4.5e-07 30.1 0.0 1.1e-06 28.8 0.0 1.7 1 1 0 1 1 1 1 Nucleotidyltransferase domain Pam16 PF03656.13 EMD58302.1 - 9.3e-31 106.5 0.4 1.1e-30 106.3 0.4 1.0 1 0 0 1 1 1 1 Pam16 Pex24p PF06398.11 EMD58303.1 - 2.4e-97 326.2 0.5 2.9e-97 325.9 0.5 1.1 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin Amidase PF01425.21 EMD58304.1 - 6.8e-116 387.9 0.0 8.1e-116 387.6 0.0 1.0 1 0 0 1 1 1 1 Amidase Bud13 PF09736.9 EMD58305.1 - 8.8e-48 162.4 12.7 8.8e-48 162.4 12.7 3.2 2 1 0 2 2 2 1 Pre-mRNA-splicing factor of RES complex TP53IP5 PF15331.6 EMD58305.1 - 0.036 14.2 7.6 0.085 13.0 7.6 1.5 1 0 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 DUF4607 PF15380.6 EMD58305.1 - 0.17 11.3 5.8 0.18 11.3 4.9 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4607) SPATIAL PF15256.6 EMD58305.1 - 0.42 10.9 2.4 0.8 10.0 2.4 1.6 1 0 0 1 1 1 0 SPATIAL Nitroreductase PF00881.24 EMD58305.1 - 1.2 9.2 12.3 0.13 12.3 0.4 2.4 2 1 1 3 3 3 0 Nitroreductase family MRP-63 PF14978.6 EMD58305.1 - 2.5 8.8 0.0 2.5 8.8 0.0 3.2 3 0 0 3 3 3 0 Mitochondrial ribosome protein 63 Casc1_N PF15927.5 EMD58305.1 - 2.8 7.6 26.3 0.096 12.4 18.2 2.3 2 0 0 2 2 2 0 Cancer susceptibility candidate 1 N-terminus DNA_binding_1 PF01035.20 EMD58306.1 - 2e-24 85.5 0.0 2.6e-24 85.1 0.0 1.1 1 0 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, DNA binding domain Abhydrolase_3 PF07859.13 EMD58308.1 - 4.1e-44 150.9 0.3 4.1e-30 105.2 0.2 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold COesterase PF00135.28 EMD58308.1 - 2.1e-08 33.5 0.1 4.2e-08 32.5 0.1 1.5 1 1 0 1 1 1 1 Carboxylesterase family Peptidase_S9 PF00326.21 EMD58308.1 - 0.042 13.3 0.0 0.49 9.8 0.0 2.2 2 0 0 2 2 2 0 Prolyl oligopeptidase family Esterase PF00756.20 EMD58308.1 - 0.11 12.1 0.0 0.42 10.2 0.0 1.9 2 0 0 2 2 2 0 Putative esterase HET PF06985.11 EMD58309.1 - 2e-21 76.9 0.0 2.7e-21 76.4 0.0 1.2 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) AAA PF00004.29 EMD58313.1 - 1.2e-57 194.0 0.0 8e-43 146.0 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EMD58313.1 - 1.2e-18 66.7 1.9 2.2e-08 33.7 0.0 2.9 2 1 0 2 2 2 2 AAA+ lid domain AAA_5 PF07728.14 EMD58313.1 - 2e-11 44.0 0.0 8.1e-07 29.1 0.0 2.7 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EMD58313.1 - 1.4e-10 41.8 1.6 0.022 15.1 0.0 4.3 2 2 1 4 4 4 2 AAA ATPase domain AAA_22 PF13401.6 EMD58313.1 - 2.5e-07 31.1 1.6 0.051 13.9 0.0 4.1 2 2 2 4 4 4 2 AAA domain AAA_33 PF13671.6 EMD58313.1 - 5.2e-06 26.7 0.0 0.0039 17.4 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_2 PF07724.14 EMD58313.1 - 9.3e-06 25.9 0.0 0.00089 19.4 0.0 2.4 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_14 PF13173.6 EMD58313.1 - 1.1e-05 25.4 0.0 0.22 11.5 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_7 PF12775.7 EMD58313.1 - 0.00014 21.5 0.0 0.41 10.2 0.0 2.6 2 1 0 2 2 2 2 P-loop containing dynein motor region AAA_28 PF13521.6 EMD58313.1 - 0.00014 22.2 0.1 0.22 11.8 0.0 3.5 3 0 0 3 3 3 1 AAA domain RuvB_N PF05496.12 EMD58313.1 - 0.00017 21.4 0.0 0.0074 16.1 0.0 2.6 2 1 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain Mg_chelatase PF01078.21 EMD58313.1 - 0.00023 20.6 0.0 0.61 9.4 0.0 2.6 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 EMD58313.1 - 0.00037 20.8 0.0 0.68 10.4 0.0 2.5 2 0 0 2 2 2 2 RNA helicase Vps4_C PF09336.10 EMD58313.1 - 0.00056 19.9 0.0 0.49 10.4 0.0 2.9 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain NACHT PF05729.12 EMD58313.1 - 0.00067 19.6 0.1 0.7 9.8 0.0 3.5 3 1 0 3 3 3 1 NACHT domain TIP49 PF06068.13 EMD58313.1 - 0.00088 18.6 0.0 0.0098 15.1 0.0 2.1 2 0 0 2 2 2 1 TIP49 P-loop domain Sigma54_activ_2 PF14532.6 EMD58313.1 - 0.0017 18.5 0.0 0.088 12.9 0.0 2.4 2 0 0 2 2 2 1 Sigma-54 interaction domain ATPase PF06745.13 EMD58313.1 - 0.002 17.5 0.0 0.092 12.1 0.0 2.6 2 1 1 3 3 3 1 KaiC TniB PF05621.11 EMD58313.1 - 0.0025 17.3 0.0 0.4 10.1 0.0 3.2 2 1 1 3 3 3 1 Bacterial TniB protein AAA_25 PF13481.6 EMD58313.1 - 0.0031 17.1 1.6 4.4 6.8 0.0 3.6 2 2 2 4 4 4 1 AAA domain CDC48_N PF02359.18 EMD58313.1 - 0.0052 16.9 0.0 0.016 15.4 0.0 1.8 2 0 0 2 2 1 1 Cell division protein 48 (CDC48), N-terminal domain IstB_IS21 PF01695.17 EMD58313.1 - 0.018 14.7 0.0 1.3 8.7 0.0 2.4 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_30 PF13604.6 EMD58313.1 - 0.029 14.1 0.0 0.58 9.8 0.0 2.7 3 0 0 3 3 3 0 AAA domain Sigma54_activat PF00158.26 EMD58313.1 - 0.032 13.9 0.0 6.3 6.5 0.0 2.9 2 1 0 2 2 2 0 Sigma-54 interaction domain AAA_3 PF07726.11 EMD58313.1 - 0.034 14.0 0.0 2.2 8.2 0.0 2.5 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) ATPase_2 PF01637.18 EMD58313.1 - 0.051 13.5 0.0 25 4.7 0.0 3.0 2 1 0 2 2 2 0 ATPase domain predominantly from Archaea Rad17 PF03215.15 EMD58313.1 - 0.067 13.1 0.0 2.6 7.9 0.0 2.5 2 0 0 2 2 2 0 Rad17 P-loop domain AAA_11 PF13086.6 EMD58313.1 - 0.13 12.0 0.1 9.9 5.9 0.0 2.4 2 1 0 2 2 2 0 AAA domain EAP30 PF04157.16 EMD58315.1 - 2.5e-64 216.8 0.0 2.8e-64 216.6 0.0 1.0 1 0 0 1 1 1 1 EAP30/Vps36 family AAR2 PF05282.11 EMD58316.1 - 3.7e-98 329.2 0.0 5.8e-98 328.5 0.0 1.2 1 0 0 1 1 1 1 AAR2 protein zf-LITAF-like PF10601.9 EMD58317.1 - 1.2e-21 76.7 8.4 1.6e-21 76.3 8.4 1.1 1 0 0 1 1 1 1 LITAF-like zinc ribbon domain NOB1_Zn_bind PF08772.11 EMD58317.1 - 1.8 8.8 0.0 1.8 8.8 0.0 2.5 1 1 1 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like PAP2 PF01569.21 EMD58318.1 - 4.2e-25 88.1 1.7 4.2e-25 88.1 1.7 1.9 2 0 0 2 2 2 1 PAP2 superfamily PAP2_C PF14360.6 EMD58318.1 - 0.061 13.9 0.8 0.061 13.9 0.8 2.2 2 0 0 2 2 2 0 PAP2 superfamily C-terminal AMP-binding PF00501.28 EMD58319.1 - 5.3e-298 987.3 0.0 1.1e-78 264.8 0.0 4.2 4 0 0 4 4 4 4 AMP-binding enzyme Condensation PF00668.20 EMD58319.1 - 1.6e-198 660.0 2.6 3.6e-36 124.8 0.2 7.2 7 0 0 7 7 7 7 Condensation domain PP-binding PF00550.25 EMD58319.1 - 3.2e-54 181.2 7.6 8e-10 38.9 0.0 7.0 6 0 0 6 6 6 6 Phosphopantetheine attachment site AMP-binding_C PF13193.6 EMD58319.1 - 6.5e-13 49.5 0.0 0.0075 17.2 0.0 5.3 5 0 0 5 5 5 4 AMP-binding enzyme C-terminal domain WES_acyltransf PF03007.16 EMD58319.1 - 0.085 12.6 0.0 28 4.4 0.0 3.2 2 0 0 2 2 2 0 Wax ester synthase-like Acyl-CoA acyltransferase domain ABC_membrane PF00664.23 EMD58320.1 - 8.8e-84 281.4 28.7 3.9e-45 154.6 13.2 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EMD58320.1 - 5e-68 227.9 0.0 1.8e-34 119.2 0.0 2.5 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EMD58320.1 - 1.3e-13 51.0 0.7 0.00063 19.3 0.0 4.5 4 1 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EMD58320.1 - 3.1e-07 30.1 0.1 0.013 15.2 0.1 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 EMD58320.1 - 6.5e-07 29.9 2.3 0.0029 18.0 0.1 3.4 3 1 0 3 3 2 2 AAA ATPase domain AAA_21 PF13304.6 EMD58320.1 - 9.1e-07 29.0 3.3 0.29 10.9 0.4 4.2 2 2 2 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 EMD58320.1 - 4.3e-06 27.0 0.7 0.019 15.2 0.1 4.5 4 1 0 4 4 4 1 AAA domain AAA_15 PF13175.6 EMD58320.1 - 1.4e-05 25.0 0.0 0.039 13.7 0.0 2.2 2 0 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 EMD58320.1 - 1.8e-05 24.7 0.0 0.3 11.0 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase Zeta_toxin PF06414.12 EMD58320.1 - 2.9e-05 23.5 0.0 0.094 12.0 0.0 2.6 2 0 0 2 2 2 2 Zeta toxin ABC_ATPase PF09818.9 EMD58320.1 - 4.5e-05 22.4 2.1 0.046 12.5 0.0 2.7 3 0 0 3 3 3 2 Predicted ATPase of the ABC class AAA PF00004.29 EMD58320.1 - 0.00063 20.2 0.0 1.9 8.9 0.0 4.1 3 1 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 EMD58320.1 - 0.0014 18.3 0.0 1.1 8.8 0.0 3.8 3 0 0 3 3 3 1 AAA domain APS_kinase PF01583.20 EMD58320.1 - 0.0016 18.3 0.0 1.1 9.1 0.0 2.6 2 0 0 2 2 2 1 Adenylylsulphate kinase AAA_7 PF12775.7 EMD58320.1 - 0.0021 17.6 0.0 0.85 9.1 0.0 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region MMR_HSR1 PF01926.23 EMD58320.1 - 0.0036 17.4 0.1 1.7 8.7 0.0 3.1 3 0 0 3 3 2 1 50S ribosome-binding GTPase AAA_23 PF13476.6 EMD58320.1 - 0.0067 16.9 0.0 0.5 10.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 EMD58320.1 - 0.0072 16.3 0.0 0.54 10.3 0.0 3.0 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 EMD58320.1 - 0.0081 16.3 0.0 0.39 10.9 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EMD58320.1 - 0.0096 15.7 0.0 3.5 7.3 0.0 3.3 3 0 0 3 3 3 1 AAA domain G-alpha PF00503.20 EMD58320.1 - 0.028 13.6 0.0 1.3 8.2 0.0 2.2 2 0 0 2 2 2 0 G-protein alpha subunit YuiB PF14068.6 EMD58320.1 - 0.035 14.7 0.4 0.18 12.4 0.4 2.4 1 0 0 1 1 1 0 Putative membrane protein IstB_IS21 PF01695.17 EMD58320.1 - 0.051 13.3 0.5 8.6 6.1 0.0 3.5 4 0 0 4 4 4 0 IstB-like ATP binding protein SbcCD_C PF13558.6 EMD58320.1 - 0.061 13.6 5.6 1.2 9.5 0.4 4.0 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit DUF87 PF01935.17 EMD58320.1 - 0.092 12.8 0.2 8.6 6.4 0.0 2.8 3 0 0 3 3 3 0 Helicase HerA, central domain AAA_24 PF13479.6 EMD58320.1 - 0.12 12.1 0.0 2.2 7.9 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 EMD58320.1 - 0.13 12.8 0.0 0.97 10.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain PRK PF00485.18 EMD58320.1 - 0.17 11.6 0.1 22 4.7 0.0 2.4 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family K_oxygenase PF13434.6 EMD58321.1 - 1.4e-100 336.8 0.0 2.1e-100 336.2 0.0 1.3 1 0 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.14 EMD58321.1 - 2.4e-08 33.6 0.0 3.8e-07 29.6 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pkinase PF00069.25 EMD58322.1 - 1.3e-49 169.0 0.0 2.5e-49 168.0 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD58322.1 - 1.8e-23 83.1 0.6 3.2e-23 82.3 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 EMD58322.1 - 0.0048 16.9 4.1 0.005 16.8 0.0 2.4 2 0 0 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.22 EMD58322.1 - 0.011 15.3 0.2 0.011 15.3 0.2 2.0 2 1 0 2 2 2 0 RIO1 family Choline_kinase PF01633.20 EMD58322.1 - 0.23 11.0 1.8 0.37 10.3 0.2 2.1 2 0 0 2 2 2 0 Choline/ethanolamine kinase TFIIA PF03153.13 EMD58322.1 - 0.59 10.1 52.1 2.2 8.2 18.0 2.6 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit eIF-3c_N PF05470.12 EMD58323.1 - 1.9e-171 571.4 29.1 1.9e-171 571.4 29.1 3.1 1 1 1 2 2 2 1 Eukaryotic translation initiation factor 3 subunit 8 N-terminus PCI PF01399.27 EMD58323.1 - 3.1e-13 50.2 2.4 6.6e-13 49.1 0.0 3.0 4 1 0 4 4 4 1 PCI domain SEEEED PF14797.6 EMD58323.1 - 6.7 6.9 34.1 0.017 15.3 24.2 1.7 2 0 0 2 2 2 0 Serine-rich region of AP3B1, clathrin-adaptor complex Per1 PF04080.13 EMD58324.1 - 1.9e-105 352.3 7.3 2.4e-105 351.9 7.3 1.1 1 0 0 1 1 1 1 Per1-like family DUF3522 PF12036.8 EMD58324.1 - 0.0026 18.0 4.2 0.0053 17.1 4.2 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3522) Nop14 PF04147.12 EMD58326.1 - 0.0041 15.4 5.4 0.3 9.3 0.0 2.1 2 0 0 2 2 2 1 Nop14-like family SDA1 PF05285.12 EMD58326.1 - 6 6.2 8.8 11 5.3 8.8 1.5 1 0 0 1 1 1 0 SDA1 Hydantoinase_B PF02538.14 EMD58327.1 - 1e-11 44.0 0.4 1.8e-11 43.1 0.1 1.4 1 1 1 2 2 2 1 Hydantoinase B/oxoprolinase Glyco_tranf_2_3 PF13641.6 EMD58329.1 - 1.4e-18 67.6 0.0 1.9e-18 67.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 EMD58329.1 - 2.1e-17 63.7 2.7 2.1e-17 63.7 2.7 2.5 2 0 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_transf_21 PF13506.6 EMD58329.1 - 1.4e-14 53.9 0.0 2.3e-14 53.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.26 EMD58329.1 - 7.6e-14 51.9 0.0 1.2e-13 51.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Cellulose_synt PF03552.14 EMD58329.1 - 2.4e-05 23.1 0.2 0.014 13.9 0.0 2.4 1 1 2 3 3 3 2 Cellulose synthase Actin PF00022.19 EMD58332.1 - 6.9e-91 304.9 0.0 7e-90 301.6 0.0 1.9 1 1 0 1 1 1 1 Actin FAT PF02259.23 EMD58332.1 - 0.15 11.2 0.0 0.22 10.7 0.0 1.1 1 0 0 1 1 1 0 FAT domain Ribosomal_L50 PF10501.9 EMD58333.1 - 1.5e-14 54.0 0.1 4.1e-14 52.7 0.1 1.8 1 0 0 1 1 1 1 Ribosomal subunit 39S Transp_cyt_pur PF02133.15 EMD58334.1 - 1.1e-19 70.5 41.8 2.3e-19 69.5 41.8 1.4 1 1 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Sec63 PF02889.16 EMD58336.1 - 2e-133 443.3 0.0 7.6e-82 274.3 0.2 2.2 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.29 EMD58336.1 - 3.5e-52 176.7 0.0 9.5e-27 93.9 0.3 3.1 3 0 0 3 3 3 2 DEAD/DEAH box helicase ResIII PF04851.15 EMD58336.1 - 7.3e-21 74.9 0.0 3.7e-10 40.1 0.0 2.5 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EMD58336.1 - 5.5e-16 58.9 0.0 2.2e-06 28.0 0.0 4.1 3 2 0 3 3 3 2 Helicase conserved C-terminal domain AAA_30 PF13604.6 EMD58336.1 - 2.5e-07 30.6 0.1 0.0036 17.1 0.3 2.6 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 EMD58336.1 - 1e-06 29.1 1.1 0.071 13.4 0.0 3.7 2 2 0 2 2 2 2 AAA domain AAA_19 PF13245.6 EMD58336.1 - 4.6e-06 27.0 0.3 0.0008 19.8 0.5 2.7 2 0 0 2 2 2 1 AAA domain Helicase_PWI PF18149.1 EMD58336.1 - 0.00012 22.2 0.0 0.00034 20.7 0.0 1.7 1 0 0 1 1 1 1 N-terminal helicase PWI domain T2SSE PF00437.20 EMD58336.1 - 0.013 14.5 0.0 1.7 7.7 0.0 2.8 3 0 0 3 3 3 0 Type II/IV secretion system protein IstB_IS21 PF01695.17 EMD58336.1 - 0.15 11.8 0.2 18 5.0 0.0 3.4 3 0 0 3 3 3 0 IstB-like ATP binding protein TniB PF05621.11 EMD58336.1 - 0.87 9.0 2.8 15 4.9 0.1 3.6 4 0 0 4 4 4 0 Bacterial TniB protein TetR_C_11 PF16859.5 EMD58336.1 - 1.4 9.3 6.4 1.5 9.2 2.4 3.2 4 0 0 4 4 4 0 Tetracyclin repressor-like, C-terminal domain Synaptobrevin PF00957.21 EMD58337.1 - 2.9e-13 49.4 0.3 6.4e-13 48.3 0.3 1.6 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 EMD58337.1 - 8.9e-10 38.5 0.0 2e-09 37.4 0.0 1.6 2 0 0 2 2 2 1 Regulated-SNARE-like domain DUF1580 PF07618.11 EMD58337.1 - 0.013 15.2 0.0 0.024 14.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1580) MFS_1 PF07690.16 EMD58340.1 - 2.7e-20 72.6 76.1 6.7e-18 64.7 53.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Polyketide_cyc2 PF10604.9 EMD58341.1 - 2.7e-08 34.2 0.0 3.1e-08 34.0 0.0 1.1 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Hemopexin PF00045.19 EMD58341.1 - 0.036 14.0 0.0 0.064 13.2 0.0 1.4 1 0 0 1 1 1 0 Hemopexin Zn_clus PF00172.18 EMD58342.1 - 2.1e-07 31.0 12.3 3.6e-07 30.2 12.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EMD58342.1 - 6.9e-07 28.4 1.3 1.4e-06 27.4 1.4 1.3 1 1 0 1 1 1 1 Fungal specific transcription factor domain IU_nuc_hydro PF01156.19 EMD58344.1 - 1.2e-17 64.5 0.0 1.4e-17 64.2 0.0 1.1 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase CFEM PF05730.11 EMD58346.1 - 5.8e-10 39.1 11.4 9.8e-10 38.4 11.4 1.4 1 0 0 1 1 1 1 CFEM domain Methyltransf_12 PF08242.12 EMD58347.1 - 2.5e-05 24.9 0.2 0.00041 21.0 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain CD45 PF12567.8 EMD58347.1 - 0.033 14.2 0.1 0.061 13.3 0.1 1.4 1 0 0 1 1 1 0 Leukocyte receptor CD45 Methyltransf_25 PF13649.6 EMD58347.1 - 0.065 13.9 0.0 0.26 12.0 0.0 2.0 2 1 0 2 2 2 0 Methyltransferase domain Peptidase_S28 PF05577.12 EMD58349.1 - 1.1e-54 185.9 0.8 1.1e-53 182.6 1.1 2.2 2 1 0 2 2 2 1 Serine carboxypeptidase S28 Caps_synth PF05704.12 EMD58350.1 - 3.2e-11 43.1 0.0 5.4e-11 42.4 0.0 1.3 1 0 0 1 1 1 1 Capsular polysaccharide synthesis protein Gly_transf_sug PF04488.15 EMD58350.1 - 2.6e-06 28.0 0.0 6e-06 26.8 0.0 1.6 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif TcdA_TcdB PF12919.7 EMD58350.1 - 0.18 11.1 0.0 0.26 10.6 0.0 1.2 1 0 0 1 1 1 0 TcdA/TcdB catalytic glycosyltransferase domain SPC25 PF06703.11 EMD58351.1 - 0.33 10.7 8.2 0.1 12.4 0.7 2.3 2 1 0 2 2 2 0 Microsomal signal peptidase 25 kDa subunit (SPC25) COesterase PF00135.28 EMD58353.1 - 1.1e-27 97.1 0.6 3.2e-20 72.5 0.5 2.9 2 1 0 2 2 2 2 Carboxylesterase family Abhydrolase_3 PF07859.13 EMD58353.1 - 0.0051 16.7 0.1 0.0088 15.9 0.1 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold SnoaL_3 PF13474.6 EMD58353.1 - 0.025 14.8 0.0 0.063 13.5 0.0 1.7 1 0 0 1 1 1 0 SnoaL-like domain Glyco_hydro_43 PF04616.14 EMD58354.1 - 1.4e-55 188.7 6.0 1.7e-55 188.4 6.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 CBM_6 PF03422.15 EMD58354.1 - 1.9e-39 134.8 3.0 5e-39 133.5 3.0 1.7 1 0 0 1 1 1 1 Carbohydrate binding module (family 6) DUF5010_C PF18099.1 EMD58354.1 - 2.4e-09 37.3 0.8 2.4e-09 37.3 0.8 2.1 2 0 0 2 2 2 1 DUF5010 C-terminal domain Glyco_hydro_32N PF00251.20 EMD58354.1 - 0.0045 16.6 2.4 0.0074 15.9 2.4 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 N-terminal domain DivIC PF04977.15 EMD58355.1 - 0.0013 18.4 0.0 0.0015 18.3 0.0 1.1 1 0 0 1 1 1 1 Septum formation initiator TSC22 PF01166.18 EMD58355.1 - 0.0015 18.8 0.2 0.0017 18.6 0.2 1.1 1 0 0 1 1 1 1 TSC-22/dip/bun family Shugoshin_N PF07558.11 EMD58355.1 - 0.0067 16.3 0.3 0.0086 15.9 0.3 1.3 1 0 0 1 1 1 1 Shugoshin N-terminal coiled-coil region NRBF2 PF08961.10 EMD58355.1 - 0.0099 15.5 0.1 0.011 15.4 0.1 1.1 1 0 0 1 1 1 1 Nuclear receptor-binding factor 2, autophagy regulator GIT_CC PF16559.5 EMD58355.1 - 0.017 15.0 0.7 0.022 14.6 0.7 1.2 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor NYD-SP28_assoc PF14775.6 EMD58355.1 - 0.054 13.6 0.4 0.075 13.2 0.4 1.1 1 0 0 1 1 1 0 Sperm tail C-terminal domain YabA PF06156.13 EMD58355.1 - 0.07 13.8 0.0 0.07 13.8 0.0 1.0 1 0 0 1 1 1 0 Initiation control protein YabA Amidohydro_1 PF01979.20 EMD58357.1 - 1.3e-22 80.6 0.4 5.1e-17 62.2 0.2 2.1 1 1 0 2 2 2 2 Amidohydrolase family Amidohydro_3 PF07969.11 EMD58357.1 - 1e-10 41.7 0.1 3.7e-07 30.0 0.0 2.2 2 0 0 2 2 2 2 Amidohydrolase family Zn_clus PF00172.18 EMD58358.1 - 5.2e-08 32.9 13.7 1.2e-07 31.7 13.7 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EMD58358.1 - 1.2e-05 24.5 2.3 2.4e-05 23.5 2.1 1.6 1 1 0 1 1 1 1 Fungal specific transcription factor domain V-set PF07686.17 EMD58358.1 - 0.059 13.5 0.0 0.2 11.8 0.0 1.9 1 0 0 1 1 1 0 Immunoglobulin V-set domain zf-CCHC PF00098.23 EMD58359.1 - 0.094 12.8 3.0 0.15 12.2 3.0 1.3 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_2 PF13696.6 EMD58359.1 - 0.18 11.6 1.1 0.24 11.3 1.1 1.2 1 0 0 1 1 1 0 Zinc knuckle HemY_N PF07219.13 EMD58359.1 - 5.5 7.2 6.4 6.5 7.0 6.4 1.2 1 0 0 1 1 1 0 HemY protein N-terminus GMC_oxred_N PF00732.19 EMD58360.1 - 1e-51 176.1 0.0 1.4e-51 175.7 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EMD58360.1 - 6.8e-25 88.3 0.0 1.2e-24 87.5 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase DAO PF01266.24 EMD58360.1 - 0.0041 16.7 0.0 0.012 15.2 0.0 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase TrkA_N PF02254.18 EMD58360.1 - 0.023 14.9 0.0 0.054 13.7 0.0 1.6 1 0 0 1 1 1 0 TrkA-N domain NAD_binding_8 PF13450.6 EMD58360.1 - 0.033 14.4 0.0 0.09 13.0 0.0 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EMD58360.1 - 0.044 13.0 0.0 0.073 12.3 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EMD58360.1 - 0.07 12.2 0.0 0.12 11.4 0.0 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein FAD_binding_2 PF00890.24 EMD58360.1 - 0.071 12.2 0.0 0.12 11.5 0.0 1.4 1 0 0 1 1 1 0 FAD binding domain YwhD PF08741.10 EMD58360.1 - 0.19 11.4 0.3 0.33 10.6 0.3 1.3 1 0 0 1 1 1 0 YwhD family CBM_14 PF01607.24 EMD58362.1 - 0.39 10.9 3.7 1.3 9.2 0.0 2.7 3 0 0 3 3 3 0 Chitin binding Peritrophin-A domain PhyH PF05721.13 EMD58363.1 - 2e-07 31.5 0.2 4.6e-07 30.3 0.2 1.6 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) DUF1479 PF07350.12 EMD58363.1 - 0.00061 18.7 0.1 0.53 9.0 0.0 2.3 2 1 0 2 2 2 2 Protein of unknown function (DUF1479) Peptidase_S15 PF02129.18 EMD58364.1 - 4.4e-40 138.0 0.1 1.8e-38 132.7 0.1 2.1 1 1 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) PepX_C PF08530.10 EMD58364.1 - 1e-33 117.2 0.0 1.4e-33 116.7 0.0 1.2 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain MFS_1 PF07690.16 EMD58365.1 - 5.8e-16 58.4 19.6 5.8e-16 58.4 19.6 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EMD58365.1 - 3.4e-09 36.1 3.0 3.4e-09 36.1 3.0 1.8 2 0 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 EMD58365.1 - 4.6e-05 22.0 0.9 7.5e-05 21.3 0.9 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) PhyH PF05721.13 EMD58366.1 - 2e-12 47.8 0.1 8.3e-12 45.8 0.0 2.1 2 1 0 2 2 2 1 Phytanoyl-CoA dioxygenase (PhyH) DUF1479 PF07350.12 EMD58366.1 - 2e-05 23.6 0.2 0.85 8.3 0.0 3.0 3 0 0 3 3 3 3 Protein of unknown function (DUF1479) Zn_clus PF00172.18 EMD58367.1 - 3.1e-05 24.0 9.0 4e-05 23.6 9.0 1.2 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EMD58368.1 - 2.4e-06 26.8 1.2 4.2e-06 26.0 1.2 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain GMC_oxred_N PF00732.19 EMD58370.1 - 4.9e-60 203.4 0.0 6.3e-60 203.0 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EMD58370.1 - 3.5e-35 121.6 0.0 6.7e-35 120.7 0.0 1.5 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.24 EMD58370.1 - 2.5e-06 26.9 0.2 0.007 15.5 0.1 2.4 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.24 EMD58370.1 - 7.7e-06 25.7 1.1 0.0016 18.1 0.1 2.6 3 0 0 3 3 3 2 FAD dependent oxidoreductase Thi4 PF01946.17 EMD58370.1 - 1.2e-05 24.7 0.0 2.4e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 Thi4 family NAD_binding_8 PF13450.6 EMD58370.1 - 1.8e-05 24.9 0.1 4.2e-05 23.7 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EMD58370.1 - 0.00041 19.7 0.2 0.0048 16.2 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EMD58370.1 - 0.0005 19.4 0.4 0.076 12.2 0.0 2.5 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EMD58370.1 - 0.0013 17.9 0.1 0.0022 17.1 0.1 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein HI0933_like PF03486.14 EMD58370.1 - 0.0023 16.7 0.9 0.014 14.1 0.0 2.1 2 0 0 2 2 2 1 HI0933-like protein NAD_binding_9 PF13454.6 EMD58370.1 - 0.038 14.0 0.0 0.069 13.1 0.0 1.4 1 0 0 1 1 1 0 FAD-NAD(P)-binding TrkA_N PF02254.18 EMD58370.1 - 0.081 13.2 0.1 0.17 12.2 0.1 1.5 1 0 0 1 1 1 0 TrkA-N domain FAD_binding_4 PF01565.23 EMD58371.1 - 1.8e-23 82.8 0.4 3.5e-23 81.9 0.4 1.5 1 0 0 1 1 1 1 FAD binding domain RTP1_C1 PF10363.9 EMD58373.1 - 8e-24 84.0 0.1 1.5e-22 79.9 0.0 2.7 2 0 0 2 2 2 1 Required for nuclear transport of RNA pol II C-terminus 1 RTP1_C2 PF10304.9 EMD58373.1 - 1.6e-08 34.1 0.8 4.4e-08 32.7 0.8 1.8 1 0 0 1 1 1 1 Required for nuclear transport of RNA pol II C-terminus 2 LSM PF01423.22 EMD58374.1 - 1.4e-18 66.3 0.3 1.7e-18 66.1 0.3 1.1 1 0 0 1 1 1 1 LSM domain PPR_3 PF13812.6 EMD58375.1 - 6.1e-06 26.2 0.0 0.032 14.3 0.0 3.8 4 0 0 4 4 4 2 Pentatricopeptide repeat domain PPR_2 PF13041.6 EMD58375.1 - 0.0094 16.1 0.0 11 6.3 0.0 3.7 4 0 0 4 4 4 2 PPR repeat family Polysacc_deac_1 PF01522.21 EMD58377.1 - 4.4e-29 100.9 0.0 6.5e-29 100.3 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase Chitin_bind_1 PF00187.19 EMD58377.1 - 6.4e-09 36.1 16.5 6.4e-09 36.1 16.5 1.7 2 0 0 2 2 2 1 Chitin recognition protein Glyco_hydro_57 PF03065.15 EMD58377.1 - 0.005 16.1 0.0 0.0063 15.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 57 Glyco_hydro_16 PF00722.21 EMD58378.1 - 2.3e-09 37.0 1.0 3.4e-09 36.4 1.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 Metallophos PF00149.28 EMD58379.1 - 2.8e-33 116.1 0.0 1.1e-28 101.1 0.0 2.3 2 0 0 2 2 2 2 Calcineurin-like phosphoesterase Glyco_hydro_65N PF03636.15 EMD58379.1 - 0.02 14.5 0.0 0.03 14.0 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain Metallophos_2 PF12850.7 EMD58379.1 - 0.18 12.0 0.0 0.58 10.3 0.0 1.8 2 0 0 2 2 2 0 Calcineurin-like phosphoesterase superfamily domain Smg4_UPF3 PF03467.15 EMD58380.1 - 2e-39 135.4 0.0 2e-39 135.4 0.0 3.7 4 1 0 4 4 4 1 Smg-4/UPF3 family RRM_1 PF00076.22 EMD58380.1 - 0.00015 21.5 0.0 0.00075 19.3 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) peroxidase PF00141.23 EMD58381.1 - 3.7e-24 85.7 0.1 5.3e-24 85.2 0.1 1.1 1 0 0 1 1 1 1 Peroxidase Peroxidase_ext PF11895.8 EMD58381.1 - 9.9e-06 25.4 0.0 2.4e-05 24.2 0.0 1.6 1 0 0 1 1 1 1 Fungal peroxidase extension region MT-A70 PF05063.14 EMD58385.1 - 2e-30 106.0 0.0 3e-30 105.4 0.0 1.3 1 0 0 1 1 1 1 MT-A70 Mito_carr PF00153.27 EMD58386.1 - 3.6e-61 203.1 2.4 1.3e-21 76.3 0.1 3.7 3 1 0 3 3 3 3 Mitochondrial carrier protein WD40 PF00400.32 EMD58387.1 - 3.6e-54 179.5 13.3 1e-10 42.0 0.1 7.3 7 0 0 7 7 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD58387.1 - 1e-15 57.8 0.4 0.0057 16.9 0.1 4.9 1 1 4 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EMD58387.1 - 4.7e-12 45.5 0.1 0.31 9.9 0.0 5.3 1 1 4 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 EMD58387.1 - 2.3e-10 39.8 9.7 0.062 11.9 0.0 5.1 1 1 4 5 5 5 4 Nucleoporin Nup120/160 NACHT PF05729.12 EMD58387.1 - 1.9e-09 37.7 0.1 5.7e-09 36.1 0.0 1.8 2 0 0 2 2 1 1 NACHT domain AAA_16 PF13191.6 EMD58387.1 - 1.4e-07 32.0 0.1 8.5e-07 29.5 0.3 2.3 2 0 0 2 2 1 1 AAA ATPase domain eIF2A PF08662.11 EMD58387.1 - 5.5e-07 29.7 0.0 0.07 13.0 0.0 2.7 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Proteasome_A_N PF10584.9 EMD58387.1 - 1.9e-05 24.2 0.2 18 5.1 0.0 5.5 7 0 0 7 7 7 0 Proteasome subunit A N-terminal signature Robl_LC7 PF03259.17 EMD58387.1 - 2.3e-05 24.1 4.1 30 4.5 0.0 5.8 5 1 0 6 6 6 0 Roadblock/LC7 domain PD40 PF07676.12 EMD58387.1 - 2.3e-05 24.2 0.5 10 6.2 0.1 5.9 6 0 0 6 6 6 0 WD40-like Beta Propeller Repeat SMP_2 PF10144.9 EMD58387.1 - 0.00029 20.5 0.0 6.9 6.3 0.0 4.4 2 2 2 4 4 4 0 Bacterial virulence factor haemolysin IKI3 PF04762.12 EMD58387.1 - 0.0011 17.1 0.3 0.95 7.4 0.1 2.8 1 1 0 2 2 2 2 IKI3 family WD40_like PF17005.5 EMD58387.1 - 0.0017 17.8 0.0 1.3 8.3 0.0 3.7 1 1 4 5 5 5 1 WD40-like domain AAA PF00004.29 EMD58387.1 - 0.0031 17.9 0.0 0.014 15.8 0.0 2.0 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Coatomer_WDAD PF04053.14 EMD58387.1 - 0.0035 16.4 0.1 8.6 5.3 0.0 3.9 1 1 4 5 5 5 0 Coatomer WD associated region APS_kinase PF01583.20 EMD58387.1 - 0.0039 17.1 0.0 0.0074 16.2 0.0 1.4 1 0 0 1 1 1 1 Adenylylsulphate kinase DUF4189 PF13827.6 EMD58387.1 - 0.0047 17.4 0.7 1.2 9.7 0.1 3.2 2 1 1 3 3 3 1 Domain of unknown function (DUF4189) KAP_NTPase PF07693.14 EMD58387.1 - 0.0049 16.2 0.0 0.008 15.4 0.0 1.3 1 0 0 1 1 1 1 KAP family P-loop domain AAA_33 PF13671.6 EMD58387.1 - 0.028 14.6 0.1 1.2 9.3 0.0 3.0 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 EMD58387.1 - 0.044 12.9 0.1 0.14 11.3 0.1 1.8 1 1 0 1 1 1 0 NB-ARC domain AAA_18 PF13238.6 EMD58387.1 - 0.057 14.0 0.2 0.34 11.5 0.1 2.4 2 1 0 2 2 2 0 AAA domain RAB3GAP2_N PF14655.6 EMD58387.1 - 0.064 12.5 0.4 32 3.6 0.0 3.7 1 1 4 5 5 5 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Bd3614-deam PF14439.6 EMD58387.1 - 0.072 13.2 3.4 5.7 7.0 0.1 4.3 5 0 0 5 5 5 0 Bd3614-like deaminase DUF3761 PF12587.8 EMD58387.1 - 0.09 13.2 2.0 1.4e+02 3.0 0.1 4.4 2 2 3 5 5 5 0 Protein of unknown function (DUF3761) AAA_30 PF13604.6 EMD58387.1 - 0.14 11.8 0.0 0.35 10.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain Defensin_RK-1 PF17860.1 EMD58387.1 - 0.15 12.5 1.3 4.6e+02 1.4 0.0 4.9 5 0 0 5 5 5 0 RK-1-like defensin AAA_22 PF13401.6 EMD58387.1 - 0.16 12.2 0.0 0.54 10.5 0.0 1.9 1 0 0 1 1 1 0 AAA domain PALB2_WD40 PF16756.5 EMD58387.1 - 2.7 6.8 8.2 15 4.4 0.5 4.0 1 1 4 5 5 5 0 Partner and localizer of BRCA2 WD40 domain TMF_DNA_bd PF12329.8 EMD58388.1 - 4e-23 81.2 15.2 4e-23 81.2 15.2 4.6 3 1 0 3 3 3 2 TATA element modulatory factor 1 DNA binding DUF3584 PF12128.8 EMD58388.1 - 1.2 6.5 43.0 1.4 6.3 43.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) CN_hydrolase PF00795.22 EMD58390.1 - 9.7e-52 175.9 0.0 1.1e-51 175.7 0.0 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase DUF739 PF05339.11 EMD58390.1 - 0.17 12.1 0.0 0.35 11.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF739) Putative_PNPOx PF01243.20 EMD58391.1 - 0.023 14.9 0.0 0.039 14.1 0.0 1.3 1 0 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase DUF866 PF05907.13 EMD58392.1 - 1.1e-66 223.5 0.1 1.3e-66 223.3 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF866) T4_baseplate PF12322.8 EMD58392.1 - 0.04 13.4 0.6 0.55 9.7 0.0 2.0 1 1 1 2 2 2 0 T4 bacteriophage base plate protein DUF4379 PF14311.6 EMD58392.1 - 0.064 13.6 1.8 0.064 13.6 1.8 1.8 1 1 0 1 1 1 0 Probable Zinc-ribbon domain Zn_ribbon_SprT PF17283.2 EMD58392.1 - 0.99 9.4 5.6 5.2 7.1 5.7 2.0 1 1 0 1 1 1 0 SprT-like zinc ribbon domain SET PF00856.28 EMD58393.1 - 2.4e-11 44.3 0.0 7.6e-11 42.7 0.0 1.9 1 1 0 1 1 1 1 SET domain TPR_2 PF07719.17 EMD58393.1 - 5.6e-05 22.9 4.9 0.0026 17.7 0.5 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 EMD58393.1 - 5.7e-05 23.5 1.1 0.0005 20.5 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EMD58393.1 - 0.0028 17.7 2.6 0.017 15.2 0.4 2.6 2 0 0 2 2 2 1 Fis1 C-terminal tetratricopeptide repeat ANAPC3 PF12895.7 EMD58393.1 - 0.0033 17.6 0.2 0.021 15.0 0.4 2.3 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 SRP_TPR_like PF17004.5 EMD58393.1 - 0.0093 16.0 0.6 0.033 14.2 0.2 2.1 2 1 0 2 2 2 1 Putative TPR-like repeat TPR_8 PF13181.6 EMD58393.1 - 0.081 13.2 1.6 0.88 9.9 0.2 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat BTAD PF03704.17 EMD58393.1 - 0.12 12.8 0.6 0.25 11.8 0.6 1.5 1 0 0 1 1 1 0 Bacterial transcriptional activator domain HSDR_N_2 PF13588.6 EMD58394.1 - 0.00061 19.8 0.0 0.00093 19.2 0.0 1.3 1 0 0 1 1 1 1 Type I restriction enzyme R protein N terminus (HSDR_N) HET PF06985.11 EMD58396.1 - 2e-18 67.1 0.2 2.1e-18 67.1 0.2 1.0 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) zf-CCHC PF00098.23 EMD58397.1 - 0.22 11.6 3.2 0.36 11.0 3.2 1.3 1 0 0 1 1 1 0 Zinc knuckle HemY_N PF07219.13 EMD58397.1 - 0.35 11.1 4.6 0.38 11.0 4.6 1.1 1 0 0 1 1 1 0 HemY protein N-terminus Peptidase_M19 PF01244.21 EMD58398.1 - 1.8e-99 332.9 0.0 2.2e-99 332.6 0.0 1.0 1 0 0 1 1 1 1 Membrane dipeptidase (Peptidase family M19) p450 PF00067.22 EMD58399.1 - 1.9e-34 119.2 0.1 2.5e-34 118.8 0.1 1.1 1 0 0 1 1 1 1 Cytochrome P450 MBOAT_2 PF13813.6 EMD58400.1 - 6.1e-20 71.3 4.0 1.5e-19 70.0 4.0 1.7 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family p450 PF00067.22 EMD58402.1 - 9.7e-35 120.2 0.0 1e-34 120.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 GST_C PF00043.25 EMD58403.1 - 0.00024 21.3 0.0 0.00044 20.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EMD58403.1 - 0.0006 19.8 0.0 0.0012 18.9 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 EMD58403.1 - 0.00068 19.9 0.0 0.0013 19.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EMD58403.1 - 0.0011 19.4 0.0 0.002 18.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EMD58403.1 - 0.021 15.0 0.0 0.038 14.2 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EMD58403.1 - 0.13 12.6 0.0 0.34 11.3 0.0 1.7 2 0 0 2 2 2 0 Glutathione S-transferase, N-terminal domain MFS_1 PF07690.16 EMD58404.1 - 5e-12 45.4 41.0 1.3e-11 44.0 28.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily AMP-binding PF00501.28 EMD58405.1 - 1.8e-72 244.3 0.0 3.8e-72 243.2 0.0 1.6 1 0 0 1 1 1 1 AMP-binding enzyme Condensation PF00668.20 EMD58405.1 - 6.4e-57 193.2 0.0 4.3e-35 121.3 0.0 3.0 3 0 0 3 3 3 2 Condensation domain PP-binding PF00550.25 EMD58405.1 - 3.6e-08 33.6 0.3 9.1e-08 32.3 0.3 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site Transferase PF02458.15 EMD58405.1 - 0.0025 16.6 0.0 0.32 9.6 0.0 2.8 3 0 0 3 3 3 2 Transferase family AMP-binding_C PF13193.6 EMD58405.1 - 0.016 16.2 0.1 0.05 14.6 0.1 1.9 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain AMP-binding PF00501.28 EMD58406.1 - 8.2e-34 116.9 0.0 1.1e-33 116.5 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme Aminotran_1_2 PF00155.21 EMD58407.1 - 1.4e-42 146.2 0.0 1.7e-42 145.9 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 EMD58407.1 - 0.0027 17.0 0.0 0.0042 16.4 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase AIG2_2 PF13772.6 EMD58408.1 - 8.8e-06 26.0 0.0 1.9e-05 25.0 0.0 1.5 1 1 0 1 1 1 1 AIG2-like family GGACT PF06094.12 EMD58408.1 - 0.0057 17.3 0.0 0.009 16.6 0.0 1.3 1 0 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like Pyr_redox_2 PF07992.14 EMD58409.1 - 1.6e-22 80.1 0.0 1.4e-21 77.0 0.0 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EMD58409.1 - 2.4e-07 30.3 2.7 0.018 14.3 0.2 3.1 2 1 1 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EMD58409.1 - 6.2e-07 29.5 0.3 0.0022 18.0 0.1 2.3 2 0 0 2 2 2 2 FAD-NAD(P)-binding FAD_binding_2 PF00890.24 EMD58409.1 - 7.5e-07 28.6 0.2 0.0001 21.5 0.1 2.4 2 1 0 2 2 2 1 FAD binding domain GIDA PF01134.22 EMD58409.1 - 2.3e-06 27.0 2.4 0.013 14.6 0.2 2.9 2 1 1 3 3 3 2 Glucose inhibited division protein A HI0933_like PF03486.14 EMD58409.1 - 7.2e-06 24.9 3.0 0.0025 16.6 0.0 2.8 3 0 0 3 3 3 2 HI0933-like protein Lycopene_cycl PF05834.12 EMD58409.1 - 6.6e-05 22.1 0.7 0.15 11.1 0.5 2.7 2 1 1 3 3 3 2 Lycopene cyclase protein FAD_binding_3 PF01494.19 EMD58409.1 - 7.6e-05 22.1 0.0 0.00014 21.3 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 EMD58409.1 - 0.00041 20.0 0.9 0.016 14.8 0.3 2.2 1 1 1 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EMD58409.1 - 0.0013 18.9 0.1 0.0027 17.9 0.1 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 EMD58409.1 - 0.01 15.1 0.1 0.019 14.2 0.1 1.4 1 0 0 1 1 1 1 Thi4 family AlaDh_PNT_C PF01262.21 EMD58409.1 - 0.01 15.1 0.0 0.022 14.1 0.0 1.6 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain DUF3492 PF11997.8 EMD58409.1 - 0.024 14.4 0.0 0.042 13.6 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3492) Pyr_redox PF00070.27 EMD58409.1 - 0.024 15.2 0.5 0.3 11.7 0.1 2.7 2 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EMD58409.1 - 0.052 12.4 0.1 0.1 11.5 0.1 1.5 1 0 0 1 1 1 0 Tryptophan halogenase FAD_oxidored PF12831.7 EMD58409.1 - 0.062 12.6 0.1 0.062 12.6 0.1 1.8 3 0 0 3 3 3 0 FAD dependent oxidoreductase MBOAT_2 PF13813.6 EMD58410.1 - 4.2e-06 26.9 0.0 1e-05 25.7 0.0 1.6 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family Acetyltransf_1 PF00583.25 EMD58410.1 - 0.00045 20.4 0.0 0.00074 19.7 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EMD58410.1 - 0.0016 18.4 0.0 0.0024 17.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EMD58410.1 - 0.0046 17.3 0.0 0.01 16.3 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain XTBD PF11952.8 EMD58410.1 - 0.055 13.2 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 XRN-Two Binding Domain, XTBD Pyr_redox_2 PF07992.14 EMD58411.1 - 2.4e-16 59.8 0.0 1.6e-14 53.8 0.0 2.1 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EMD58411.1 - 3.7e-05 23.5 1.4 0.00016 21.4 0.5 2.2 1 1 1 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EMD58411.1 - 7.8e-05 21.9 0.2 0.00063 18.9 0.0 2.3 2 1 1 3 3 3 1 FAD binding domain Pyr_redox_3 PF13738.6 EMD58411.1 - 0.00062 19.1 0.1 1.5 8.0 0.0 3.0 1 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EMD58411.1 - 0.0012 19.0 0.4 0.003 17.8 0.2 1.8 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 EMD58411.1 - 0.0084 15.4 0.0 0.012 14.8 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 EMD58411.1 - 0.019 13.7 0.0 0.39 9.4 0.0 2.1 2 0 0 2 2 2 0 HI0933-like protein Lycopene_cycl PF05834.12 EMD58411.1 - 0.036 13.1 0.0 0.063 12.3 0.0 1.4 1 0 0 1 1 1 0 Lycopene cyclase protein NAD_binding_9 PF13454.6 EMD58411.1 - 0.04 13.9 0.1 1.2 9.1 0.0 2.3 2 0 0 2 2 2 0 FAD-NAD(P)-binding AlaDh_PNT_C PF01262.21 EMD58411.1 - 0.12 11.6 0.0 0.2 11.0 0.0 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.22 EMD58411.1 - 0.13 11.3 0.0 0.35 9.9 0.0 1.7 2 0 0 2 2 2 0 Glucose inhibited division protein A MORN_2 PF07661.13 EMD58412.1 - 1.3 9.5 3.4 2.3 8.7 0.2 2.8 3 0 0 3 3 3 0 MORN repeat variant HILPDA PF15220.6 EMD58413.1 - 0.1 12.7 0.3 0.38 10.9 0.0 2.0 2 0 0 2 2 2 0 Hypoxia-inducible lipid droplet-associated TAP42 PF04177.12 EMD58413.1 - 0.16 11.0 0.1 0.22 10.6 0.1 1.3 1 0 0 1 1 1 0 TAP42-like family Zn_clus PF00172.18 EMD58414.1 - 1.7e-09 37.6 9.9 5.9e-09 35.9 9.9 2.0 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SPX PF03105.19 EMD58414.1 - 9.6 6.0 9.9 16 5.2 9.9 1.4 1 0 0 1 1 1 0 SPX domain AMP-binding PF00501.28 EMD58415.1 - 2.5e-74 250.4 0.0 3.3e-74 250.0 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EMD58415.1 - 0.00011 23.1 0.8 0.00037 21.4 0.3 2.2 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain Methyltransf_2 PF00891.18 EMD58416.1 - 6.9e-33 113.7 0.0 1.2e-32 112.9 0.0 1.4 1 0 0 1 1 1 1 O-methyltransferase domain Dimerisation2 PF16864.5 EMD58416.1 - 1.8e-07 31.0 0.2 6.6e-07 29.2 0.1 1.9 2 0 0 2 2 2 1 Dimerisation domain Transp_cyt_pur PF02133.15 EMD58417.1 - 2.7e-94 316.4 35.4 3.1e-94 316.2 35.4 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin DctQ PF04290.12 EMD58417.1 - 8.7 6.3 18.8 3.1 7.7 0.2 3.3 3 1 0 3 3 3 0 Tripartite ATP-independent periplasmic transporters, DctQ component Methyltransf_2 PF00891.18 EMD58418.1 - 2.7e-19 69.3 0.0 4e-19 68.7 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain DREV PF05219.12 EMD58418.1 - 0.029 13.5 0.0 0.043 12.9 0.0 1.3 1 0 0 1 1 1 0 DREV methyltransferase Methyltransf_25 PF13649.6 EMD58418.1 - 0.087 13.5 0.3 0.25 12.1 0.1 2.0 2 0 0 2 2 2 0 Methyltransferase domain p450 PF00067.22 EMD58419.1 - 1.6e-28 99.7 0.0 2.1e-28 99.3 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 DDE_1 PF03184.19 EMD58420.1 - 7.4e-18 64.8 0.1 8.3e-18 64.6 0.1 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease Ank_2 PF12796.7 EMD58421.1 - 1.6e-36 124.8 42.8 2.3e-11 44.1 2.3 4.8 2 1 4 6 6 6 5 Ankyrin repeats (3 copies) HET PF06985.11 EMD58421.1 - 2.8e-35 121.8 1.2 7.3e-35 120.5 1.2 1.8 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Ank_4 PF13637.6 EMD58421.1 - 2.5e-28 98.0 7.3 1.3e-06 28.8 0.1 6.5 1 1 4 6 6 6 6 Ankyrin repeats (many copies) Ank PF00023.30 EMD58421.1 - 4.2e-17 61.7 35.4 0.036 14.5 0.2 8.7 9 0 0 9 9 9 7 Ankyrin repeat Ank_3 PF13606.6 EMD58421.1 - 6.5e-12 44.5 17.8 1.7 9.5 0.0 8.8 9 0 0 9 9 9 5 Ankyrin repeat Ank_5 PF13857.6 EMD58421.1 - 1.8e-06 28.1 15.5 0.13 12.6 0.1 6.5 2 1 6 8 8 8 5 Ankyrin repeats (many copies) FLgD_tudor PF13861.6 EMD58421.1 - 0.003 17.7 4.6 4.1 7.7 0.0 4.4 3 2 0 3 3 3 1 FlgD Tudor-like domain MFS_1 PF07690.16 EMD58422.1 - 1.1e-39 136.4 37.8 6.9e-34 117.3 25.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily ABC_tran PF00005.27 EMD58423.1 - 8.8e-34 117.0 0.0 2e-33 115.8 0.0 1.7 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 EMD58423.1 - 1.2e-27 97.3 14.2 2.6e-27 96.2 14.2 1.6 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 EMD58423.1 - 1e-08 34.9 0.8 7e-07 28.9 0.8 2.5 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EMD58423.1 - 0.00039 20.1 0.5 0.0011 18.7 0.1 2.0 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_16 PF13191.6 EMD58423.1 - 0.0024 18.3 0.1 0.0087 16.5 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EMD58423.1 - 0.0025 18.1 0.1 0.0078 16.5 0.1 1.8 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 EMD58423.1 - 0.0044 17.0 0.0 0.0092 15.9 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_24 PF13479.6 EMD58423.1 - 0.0046 16.7 0.0 0.0095 15.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_23 PF13476.6 EMD58423.1 - 0.009 16.5 0.1 0.017 15.6 0.1 1.3 1 0 0 1 1 1 1 AAA domain AAA_21 PF13304.6 EMD58423.1 - 0.01 15.7 0.1 0.039 13.8 0.0 2.0 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 EMD58423.1 - 0.017 14.8 0.0 0.029 14.1 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain AAA_30 PF13604.6 EMD58423.1 - 0.032 14.0 0.1 0.081 12.6 0.1 1.7 1 1 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 EMD58423.1 - 0.061 13.2 0.1 0.35 10.8 0.1 2.1 1 1 0 1 1 1 0 NTPase ATP-synt_ab PF00006.25 EMD58423.1 - 0.065 12.9 0.0 0.13 11.9 0.0 1.5 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_10 PF12846.7 EMD58423.1 - 0.085 11.8 0.0 0.15 10.9 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain SbcCD_C PF13558.6 EMD58423.1 - 0.11 12.7 0.2 1.3 9.3 0.2 2.5 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit DUF87 PF01935.17 EMD58423.1 - 0.13 12.3 0.1 0.28 11.2 0.1 1.4 1 0 0 1 1 1 0 Helicase HerA, central domain EphA2_TM PF14575.6 EMD58423.1 - 0.86 10.5 2.8 16 6.5 0.0 3.2 3 0 0 3 3 2 0 Ephrin type-A receptor 2 transmembrane domain GST_N_2 PF13409.6 EMD58424.1 - 4.5e-09 36.5 0.0 1.1e-08 35.3 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EMD58424.1 - 3e-08 33.8 0.4 5.1e-08 33.0 0.4 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EMD58424.1 - 6.3e-08 32.9 0.1 1.1e-07 32.1 0.1 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EMD58424.1 - 6.9e-06 26.2 0.7 1.4e-05 25.1 0.3 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EMD58424.1 - 0.00036 20.8 0.0 0.00071 19.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EMD58424.1 - 0.0024 17.8 0.0 0.0047 16.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Tom37 PF10568.9 EMD58424.1 - 0.11 12.9 0.2 0.18 12.1 0.2 1.4 1 0 0 1 1 1 0 Outer mitochondrial membrane transport complex protein DDA1 PF10172.9 EMD58424.1 - 0.21 11.8 0.7 0.43 10.9 0.2 1.8 2 0 0 2 2 2 0 Det1 complexing ubiquitin ligase p450 PF00067.22 EMD58425.1 - 1.6e-42 145.9 0.0 2e-42 145.5 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Hydrolase_2 PF07486.12 EMD58426.1 - 0.064 14.1 0.0 0.69 10.8 0.0 2.5 1 1 2 3 3 3 0 Cell Wall Hydrolase UBA PF00627.31 EMD58427.1 - 3.2e-06 26.9 0.0 5.5e-06 26.2 0.0 1.4 1 0 0 1 1 1 1 UBA/TS-N domain XAP5 PF04921.14 EMD58428.1 - 1.5e-85 287.0 0.0 2.1e-85 286.5 0.0 1.1 1 0 0 1 1 1 1 XAP5, circadian clock regulator GDPD PF03009.17 EMD58429.1 - 6.2e-74 249.0 0.0 1e-73 248.3 0.0 1.3 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family Ank_2 PF12796.7 EMD58429.1 - 5.7e-27 94.1 0.3 7.3e-09 36.1 0.0 4.5 3 1 2 5 5 5 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMD58429.1 - 8.4e-24 83.6 3.6 4.3e-08 33.6 0.0 4.9 5 0 0 5 5 5 3 Ankyrin repeats (many copies) SPX PF03105.19 EMD58429.1 - 1.2e-23 84.7 9.6 4.7e-12 46.5 0.0 4.4 2 1 1 4 4 4 3 SPX domain Ank_5 PF13857.6 EMD58429.1 - 4.7e-21 74.6 1.0 5.8e-09 36.0 0.0 5.5 3 1 2 5 5 5 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMD58429.1 - 1e-13 50.1 3.6 0.05 14.2 0.0 7.3 7 0 0 7 7 7 3 Ankyrin repeat Ank PF00023.30 EMD58429.1 - 7.4e-13 48.3 10.5 0.00046 20.5 0.0 6.8 6 1 0 6 6 6 3 Ankyrin repeat UQ_con PF00179.26 EMD58430.1 - 7.9e-33 113.1 0.0 1.4e-32 112.3 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EMD58430.1 - 0.0089 15.7 0.0 0.031 14.0 0.0 1.8 1 1 1 2 2 2 1 Prokaryotic E2 family B Nup160 PF11715.8 EMD58431.1 - 1.6e-126 423.1 0.2 2.1e-126 422.7 0.2 1.1 1 0 0 1 1 1 1 Nucleoporin Nup120/160 Aldo_ket_red PF00248.21 EMD58432.1 - 1e-49 169.3 0.0 5.7e-48 163.6 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family Nefa_Nip30_N PF10187.9 EMD58433.1 - 2.9e-26 91.8 12.9 2.9e-26 91.8 12.9 2.6 2 1 0 2 2 2 1 N-terminal domain of NEFA-interacting nuclear protein NIP30 DUF572 PF04502.13 EMD58433.1 - 0.25 10.9 21.4 0.33 10.5 21.4 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) MFS_1 PF07690.16 EMD58434.1 - 8.8e-29 100.5 48.3 7.4e-17 61.3 13.9 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily FAD_binding_4 PF01565.23 EMD58435.1 - 3.3e-20 72.2 0.8 5.2e-20 71.6 0.8 1.3 1 0 0 1 1 1 1 FAD binding domain Peptidase_A6 PF01829.16 EMD58435.1 - 0.039 13.3 0.2 0.083 12.2 0.2 1.5 2 0 0 2 2 2 0 Peptidase A6 family SLAC1 PF03595.17 EMD58436.1 - 1.2e-63 215.4 47.2 1.3e-63 215.2 47.2 1.0 1 0 0 1 1 1 1 Voltage-dependent anion channel MIP PF00230.20 EMD58437.1 - 2.6e-35 122.2 7.7 3.8e-35 121.6 7.7 1.2 1 0 0 1 1 1 1 Major intrinsic protein Vps26 PF03643.15 EMD58438.1 - 3.7e-128 426.3 0.5 4.3e-128 426.1 0.5 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_N PF00339.29 EMD58438.1 - 0.0013 18.8 1.6 0.52 10.4 1.6 3.3 1 1 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain IL17R_D_N PF16742.5 EMD58438.1 - 0.07 13.2 0.1 0.14 12.2 0.1 1.4 1 0 0 1 1 1 0 N-terminus of interleukin 17 receptor D DUF3915 PF13054.6 EMD58439.1 - 0.0055 16.7 0.5 0.007 16.3 0.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3915) Atrophin-1 PF03154.15 EMD58439.1 - 0.0058 15.0 3.7 0.0066 14.8 3.7 1.0 1 0 0 1 1 1 1 Atrophin-1 family Connexin PF00029.19 EMD58439.1 - 0.047 13.5 0.0 0.052 13.3 0.0 1.1 1 0 0 1 1 1 0 Connexin FAM27 PF15832.5 EMD58439.1 - 0.13 12.8 6.2 0.18 12.4 6.1 1.4 1 1 0 1 1 1 0 FAM27 D and E protein family SKI PF01202.22 EMD58440.1 - 3.4e-12 46.8 0.0 4.2e-12 46.5 0.0 1.2 1 0 0 1 1 1 1 Shikimate kinase AAA_18 PF13238.6 EMD58440.1 - 9.8e-10 39.1 0.0 2e-09 38.1 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EMD58440.1 - 1.1e-07 32.1 0.0 1.7e-07 31.5 0.0 1.2 1 0 0 1 1 1 1 AAA domain Rad17 PF03215.15 EMD58440.1 - 5.1e-07 29.8 0.0 8.8e-07 29.0 0.0 1.3 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_17 PF13207.6 EMD58440.1 - 1.2e-06 29.0 0.0 2.2e-06 28.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain Cytidylate_kin PF02224.18 EMD58440.1 - 6.8e-06 26.0 0.0 1.2e-05 25.2 0.0 1.5 1 1 0 1 1 1 1 Cytidylate kinase dNK PF01712.19 EMD58440.1 - 8.3e-06 25.8 0.1 0.016 15.1 0.0 2.1 1 1 1 2 2 2 2 Deoxynucleoside kinase AAA_22 PF13401.6 EMD58440.1 - 0.00016 21.9 0.1 0.0005 20.4 0.1 1.8 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EMD58440.1 - 0.00035 21.0 0.0 0.00051 20.5 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain Ploopntkinase1 PF18748.1 EMD58440.1 - 0.00067 19.2 0.0 0.8 9.2 0.0 2.1 2 0 0 2 2 2 2 P-loop Nucleotide Kinase1 AAA_28 PF13521.6 EMD58440.1 - 0.00083 19.6 0.0 0.0017 18.6 0.0 1.5 2 0 0 2 2 1 1 AAA domain ABC_tran PF00005.27 EMD58440.1 - 0.003 18.1 0.0 0.0043 17.6 0.0 1.5 1 1 0 1 1 1 1 ABC transporter Mg_chelatase PF01078.21 EMD58440.1 - 0.0033 16.8 0.1 0.0057 16.1 0.1 1.3 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_14 PF13173.6 EMD58440.1 - 0.0054 16.8 0.0 0.016 15.3 0.0 1.8 2 1 1 3 3 1 1 AAA domain AAA_5 PF07728.14 EMD58440.1 - 0.0058 16.6 0.0 0.012 15.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Cytidylate_kin2 PF13189.6 EMD58440.1 - 0.0068 16.5 0.1 0.062 13.4 0.0 2.0 2 0 0 2 2 2 1 Cytidylate kinase-like family AAA PF00004.29 EMD58440.1 - 0.0085 16.5 0.0 0.016 15.6 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 EMD58440.1 - 0.0086 16.5 0.0 0.019 15.3 0.0 1.6 1 0 0 1 1 1 1 RNA helicase NACHT PF05729.12 EMD58440.1 - 0.0096 15.9 0.0 0.016 15.1 0.0 1.3 1 0 0 1 1 1 1 NACHT domain tRNA_lig_kinase PF08303.11 EMD58440.1 - 0.012 15.7 0.0 0.026 14.6 0.0 1.6 1 1 0 1 1 1 0 tRNA ligase kinase domain NTPase_1 PF03266.15 EMD58440.1 - 0.014 15.4 0.2 0.31 10.9 0.0 2.1 2 0 0 2 2 2 0 NTPase CoaE PF01121.20 EMD58440.1 - 0.015 14.9 0.0 0.033 13.9 0.0 1.5 1 0 0 1 1 1 0 Dephospho-CoA kinase AAA_30 PF13604.6 EMD58440.1 - 0.024 14.3 0.0 0.048 13.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 EMD58440.1 - 0.032 13.3 0.6 0.088 11.8 0.0 1.8 2 0 0 2 2 2 0 Type II/IV secretion system protein APS_kinase PF01583.20 EMD58440.1 - 0.037 13.9 0.0 0.057 13.3 0.0 1.3 1 1 0 1 1 1 0 Adenylylsulphate kinase PRK PF00485.18 EMD58440.1 - 0.04 13.7 0.0 0.13 12.0 0.0 1.8 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family AAA_29 PF13555.6 EMD58440.1 - 0.049 13.4 0.0 0.088 12.6 0.0 1.3 1 0 0 1 1 1 0 P-loop containing region of AAA domain NB-ARC PF00931.22 EMD58440.1 - 0.058 12.6 0.0 0.096 11.9 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain SMC_N PF02463.19 EMD58440.1 - 0.064 12.7 0.0 0.14 11.5 0.0 1.5 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain Viral_helicase1 PF01443.18 EMD58440.1 - 0.064 13.0 0.0 0.1 12.3 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_7 PF12775.7 EMD58440.1 - 0.068 12.7 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region PhoH PF02562.16 EMD58440.1 - 0.089 12.2 0.0 0.18 11.2 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein AAA_25 PF13481.6 EMD58440.1 - 0.092 12.3 0.0 0.27 10.8 0.0 1.7 2 0 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 EMD58440.1 - 0.095 12.6 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase ATPase_2 PF01637.18 EMD58440.1 - 0.1 12.5 0.0 0.17 11.7 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea DUF2075 PF09848.9 EMD58440.1 - 0.1 11.8 0.3 0.42 9.8 0.0 1.8 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2075) IstB_IS21 PF01695.17 EMD58440.1 - 0.13 12.0 0.3 1.1 9.0 0.0 2.3 2 1 0 2 2 2 0 IstB-like ATP binding protein AAA_23 PF13476.6 EMD58440.1 - 0.15 12.5 0.0 0.3 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain TMEM154 PF15102.6 EMD58441.1 - 0.028 14.3 0.2 0.033 14.1 0.2 1.1 1 0 0 1 1 1 0 TMEM154 protein family Mid2 PF04478.12 EMD58441.1 - 0.12 12.2 0.1 0.15 11.9 0.1 1.2 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor Syndecan PF01034.20 EMD58441.1 - 0.17 11.8 3.0 0.25 11.3 3.0 1.2 1 0 0 1 1 1 0 Syndecan domain YebO PF13974.6 EMD58441.1 - 0.27 11.3 0.7 0.45 10.6 0.7 1.3 1 0 0 1 1 1 0 YebO-like protein Sulfate_transp PF00916.20 EMD58442.1 - 4.2e-63 213.4 18.1 7.7e-63 212.5 18.1 1.3 1 0 0 1 1 1 1 Sulfate permease family cNMP_binding PF00027.29 EMD58442.1 - 2.4e-15 56.3 0.0 4.6e-15 55.4 0.0 1.5 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain STAS PF01740.21 EMD58442.1 - 1.6e-07 31.0 0.1 3.2e-07 30.0 0.1 1.5 1 0 0 1 1 1 1 STAS domain Dicty_CAR PF05462.11 EMD58442.1 - 0.00086 18.5 3.6 0.0015 17.7 3.6 1.3 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor MFS_MOT1 PF16983.5 EMD58442.1 - 0.97 9.9 19.1 0.68 10.4 1.8 3.4 3 0 0 3 3 3 0 Molybdate transporter of MFS superfamily DAGK_cat PF00781.24 EMD58443.1 - 2.9e-23 81.9 0.1 4.3e-23 81.3 0.1 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain Adaptin_N PF01602.20 EMD58444.1 - 6.5e-90 302.2 1.7 1.4e-89 301.0 1.7 1.4 1 0 0 1 1 1 1 Adaptin N terminal region Coatamer_beta_C PF07718.12 EMD58444.1 - 3e-58 195.7 1.5 6.8e-58 194.5 1.5 1.7 1 0 0 1 1 1 1 Coatomer beta C-terminal region Coatomer_b_Cpla PF14806.6 EMD58444.1 - 2.1e-57 192.6 0.0 5.5e-57 191.3 0.0 1.7 1 0 0 1 1 1 1 Coatomer beta subunit appendage platform Cnd1 PF12717.7 EMD58444.1 - 1e-09 38.6 0.1 1e-09 38.6 0.1 3.6 3 1 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EMD58444.1 - 7.6e-08 32.6 0.0 0.00075 19.8 0.0 4.7 3 2 2 5 5 5 2 HEAT repeats Coatomer_g_Cpla PF16381.5 EMD58444.1 - 0.00022 21.3 0.0 0.00099 19.2 0.0 2.2 2 0 0 2 2 2 1 Coatomer subunit gamma-1 C-terminal appendage platform HEAT PF02985.22 EMD58444.1 - 0.0031 17.6 0.4 0.69 10.3 0.0 4.5 6 0 0 6 6 6 1 HEAT repeat HEAT_EZ PF13513.6 EMD58444.1 - 0.0047 17.4 0.2 0.95 10.0 0.0 4.3 3 1 1 4 4 4 1 HEAT-like repeat AP4E_app_platf PF14807.6 EMD58444.1 - 0.019 15.3 0.4 0.063 13.6 0.4 1.9 1 0 0 1 1 1 0 Adaptin AP4 complex epsilon appendage platform Mago_nashi PF02792.14 EMD58445.1 - 2e-72 241.9 0.2 2.2e-72 241.8 0.2 1.0 1 0 0 1 1 1 1 Mago nashi protein Vac_ImportDeg PF09783.9 EMD58446.1 - 4.7e-68 228.1 0.4 5.9e-68 227.8 0.4 1.1 1 0 0 1 1 1 1 Vacuolar import and degradation protein Methyltransf_4 PF02390.17 EMD58447.1 - 7.9e-53 178.5 0.0 1.7e-52 177.4 0.0 1.6 1 1 0 1 1 1 1 Putative methyltransferase Methyltransf_25 PF13649.6 EMD58447.1 - 9.6e-06 26.2 0.0 3.6e-05 24.4 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMD58447.1 - 1.3e-05 25.9 0.0 3.7e-05 24.4 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EMD58447.1 - 0.00011 21.8 0.0 0.00057 19.5 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_31 PF13847.6 EMD58447.1 - 0.00034 20.4 0.0 0.00066 19.5 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 EMD58447.1 - 0.0041 17.1 0.0 0.0089 16.0 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMD58447.1 - 0.0092 16.6 0.2 0.078 13.6 0.0 2.5 2 1 0 2 2 2 1 Methyltransferase domain CMAS PF02353.20 EMD58447.1 - 0.067 12.5 0.0 0.14 11.5 0.0 1.5 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_18 PF12847.7 EMD58447.1 - 0.092 12.7 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Oxidored_FMN PF00724.20 EMD58448.1 - 4.1e-63 213.7 0.0 4.6e-60 203.7 0.0 2.5 1 1 1 2 2 2 2 NADH:flavin oxidoreductase / NADH oxidase family CsbD PF05532.12 EMD58449.1 - 6.5e-06 25.9 7.0 0.00036 20.4 0.2 2.2 2 0 0 2 2 2 2 CsbD-like Helo_like_N PF17111.5 EMD58451.1 - 3.1e-07 30.0 0.6 3.1e-07 30.0 0.6 2.1 2 1 0 2 2 2 1 Fungal N-terminal domain of STAND proteins Tk-SP_N-pro PF18237.1 EMD58451.1 - 0.028 14.5 0.1 0.14 12.3 0.1 2.2 1 0 0 1 1 1 0 Tk-SP N-propeptide domain zf-CCHC_5 PF14787.6 EMD58452.1 - 0.057 13.1 0.7 0.13 12.0 0.7 1.6 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger zf-CCHC_3 PF13917.6 EMD58452.1 - 0.068 13.1 0.5 0.12 12.4 0.5 1.4 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_2 PF13696.6 EMD58452.1 - 0.24 11.3 1.5 0.48 10.3 1.5 1.5 1 0 0 1 1 1 0 Zinc knuckle adh_short PF00106.25 EMD58455.1 - 5.5e-34 117.3 1.3 7.9e-22 77.7 0.1 2.4 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EMD58455.1 - 5.6e-32 111.2 2.9 5.5e-16 58.8 0.4 2.5 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase WD40 PF00400.32 EMD58455.1 - 3.9e-24 84.4 0.8 1.9e-05 25.3 0.1 6.8 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD58455.1 - 3.2e-13 49.8 0.1 0.012 15.9 0.0 5.4 1 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain KR PF08659.10 EMD58455.1 - 4.4e-11 43.0 0.2 2.7e-10 40.4 0.2 2.2 2 0 0 2 2 2 1 KR domain WD40_like PF17005.5 EMD58455.1 - 0.001 18.5 0.0 1.7 7.9 0.0 3.8 3 1 0 3 3 3 1 WD40-like domain Polysacc_synt_2 PF02719.15 EMD58455.1 - 0.0024 17.0 0.0 0.0038 16.4 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Cytochrom_D1 PF02239.16 EMD58455.1 - 0.012 14.2 0.1 0.4 9.1 0.0 2.2 2 0 0 2 2 2 0 Cytochrome D1 heme domain tRNA_lig_CPD PF08302.11 EMD58456.1 - 1.8e-87 293.0 0.1 2.5e-87 292.5 0.1 1.2 1 0 0 1 1 1 1 Fungal tRNA ligase phosphodiesterase domain RNA_lig_T4_1 PF09511.10 EMD58456.1 - 3.9e-81 272.1 0.1 1e-80 270.7 0.0 1.8 2 0 0 2 2 2 1 RNA ligase tRNA_lig_kinase PF08303.11 EMD58456.1 - 4.1e-51 173.4 0.2 1.7e-50 171.4 0.0 2.1 2 0 0 2 2 2 1 tRNA ligase kinase domain AAA_18 PF13238.6 EMD58456.1 - 0.018 15.6 0.0 0.087 13.4 0.0 2.2 1 1 0 1 1 1 0 AAA domain dNK PF01712.19 EMD58456.1 - 0.11 12.4 1.4 2 8.2 0.0 3.1 3 1 0 3 3 3 0 Deoxynucleoside kinase HgmA PF04209.13 EMD58457.1 - 1.5e-164 547.7 0.1 1.7e-164 547.5 0.1 1.0 1 0 0 1 1 1 1 homogentisate 1,2-dioxygenase Got1 PF04178.12 EMD58458.1 - 3e-35 121.0 14.9 4.1e-35 120.6 14.9 1.2 1 0 0 1 1 1 1 Got1/Sft2-like family DUF2070 PF09843.9 EMD58458.1 - 4.9 5.3 6.9 6.1 5.0 6.9 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) HLH PF00010.26 EMD58460.1 - 5.8e-12 45.4 0.0 2.4e-11 43.4 0.0 2.0 1 1 0 1 1 1 1 Helix-loop-helix DNA-binding domain DUF3646 PF12362.8 EMD58460.1 - 0.11 12.8 0.1 0.23 11.8 0.1 1.4 1 0 0 1 1 1 0 DNA polymerase III gamma and tau subunits C terminal NPR3 PF03666.13 EMD58463.1 - 4.1e-136 454.5 0.0 9.2e-136 453.3 0.0 1.6 1 0 0 1 1 1 1 Nitrogen Permease regulator of amino acid transport activity 3 CHCH PF06747.13 EMD58463.1 - 0.00087 19.4 0.6 0.0015 18.6 0.6 1.4 1 0 0 1 1 1 1 CHCH domain Pet191_N PF10203.9 EMD58463.1 - 0.044 14.1 0.5 0.1 12.9 0.5 1.6 1 0 0 1 1 1 0 Cytochrome c oxidase assembly protein PET191 p450 PF00067.22 EMD58464.1 - 3.9e-83 279.7 0.0 5.1e-83 279.4 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 FAD_binding_1 PF00667.20 EMD58464.1 - 1.2e-33 116.6 0.0 2e-33 115.9 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 EMD58464.1 - 2e-27 96.2 0.0 4.1e-27 95.2 0.0 1.6 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 EMD58464.1 - 2.4e-13 50.7 0.0 1.9e-12 47.8 0.0 2.4 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain Flavodoxin_5 PF12724.7 EMD58464.1 - 0.00022 21.5 0.0 0.0005 20.3 0.0 1.6 1 0 0 1 1 1 1 Flavodoxin domain Flavodoxin_NdrI PF07972.11 EMD58464.1 - 0.0078 16.4 0.0 0.016 15.3 0.0 1.5 1 0 0 1 1 1 1 NrdI Flavodoxin like Ctr PF04145.15 EMD58465.1 - 0.048 14.3 0.9 0.18 12.4 0.0 2.5 4 0 0 4 4 4 0 Ctr copper transporter family KdgT PF03812.13 EMD58465.1 - 0.051 12.9 1.3 0.13 11.6 0.1 2.1 2 0 0 2 2 2 0 2-keto-3-deoxygluconate permease ECH_1 PF00378.20 EMD58466.1 - 8.2e-10 38.4 0.0 1e-09 38.1 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase DUF4328 PF14219.6 EMD58467.1 - 0.027 14.0 0.1 0.056 13.0 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4328) DUF4418 PF14387.6 EMD58467.1 - 0.043 14.0 3.5 0.11 12.7 3.5 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4418) HET PF06985.11 EMD58468.1 - 1.6e-32 112.9 1.0 3.2e-32 111.9 0.3 1.9 2 1 0 2 2 2 1 Heterokaryon incompatibility protein (HET) DUF2263 PF10021.9 EMD58469.1 - 2.4e-15 57.2 0.0 1.4e-14 54.7 0.0 2.0 1 1 1 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2263) Macro PF01661.21 EMD58469.1 - 0.00044 20.3 0.0 0.00068 19.7 0.0 1.3 1 0 0 1 1 1 1 Macro domain Pec_lyase_C PF00544.19 EMD58470.1 - 2.6e-14 53.3 10.0 1.5e-12 47.5 10.0 2.3 1 1 0 1 1 1 1 Pectate lyase Beta_helix PF13229.6 EMD58470.1 - 0.0021 17.9 18.4 0.11 12.3 2.3 2.4 1 1 0 2 2 2 2 Right handed beta helix region Peptidase_M49 PF03571.15 EMD58471.1 - 7.4e-244 810.2 0.0 8.8e-244 810.0 0.0 1.0 1 0 0 1 1 1 1 Peptidase family M49 2C_adapt PF08793.10 EMD58471.1 - 0.15 12.2 0.1 0.34 11.1 0.1 1.5 1 0 0 1 1 1 0 2-cysteine adaptor domain Oxidored_FMN PF00724.20 EMD58472.1 - 1.3e-90 304.2 0.0 1.5e-90 304.0 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family PRAI PF00697.22 EMD58472.1 - 0.099 12.4 0.0 0.19 11.5 0.0 1.4 1 0 0 1 1 1 0 N-(5'phosphoribosyl)anthranilate (PRA) isomerase MFS_1 PF07690.16 EMD58473.1 - 2.9e-44 151.4 57.9 7.5e-44 150.1 55.8 2.8 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EMD58473.1 - 6.3e-15 54.6 15.6 1.2e-14 53.7 15.6 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EMD58473.1 - 2.5e-14 53.0 12.4 2.5e-14 53.0 12.4 2.7 3 0 0 3 3 3 2 Sugar (and other) transporter Polysacc_deac_1 PF01522.21 EMD58474.1 - 8.8e-16 57.9 0.0 1.6e-15 57.1 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase Fungal_trans PF04082.18 EMD58475.1 - 1.8e-25 89.5 0.1 3.3e-25 88.6 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD58476.1 - 6.3e-09 35.8 11.7 8.5e-09 35.4 11.7 1.2 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Transp_cyt_pur PF02133.15 EMD58477.1 - 3.5e-95 319.4 44.3 4.1e-95 319.2 44.3 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Amidase PF01425.21 EMD58478.1 - 2.2e-69 234.5 0.1 4.6e-69 233.5 0.1 1.5 1 1 0 1 1 1 1 Amidase Put_DNA-bind_N PF06971.13 EMD58479.1 - 0.04 13.9 0.0 0.087 12.9 0.0 1.6 1 0 0 1 1 1 0 Putative DNA-binding protein N-terminus RNA_pol_3_Rpc31 PF11705.8 EMD58479.1 - 0.086 13.1 9.3 0.15 12.3 9.3 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Nop14 PF04147.12 EMD58479.1 - 2.2 6.4 9.3 2.8 6.0 9.3 1.1 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.12 EMD58479.1 - 7.4 5.9 11.3 9.6 5.5 11.3 1.1 1 0 0 1 1 1 0 SDA1 p450 PF00067.22 EMD58480.1 - 6.5e-55 186.7 0.0 8e-55 186.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 CWC25 PF12542.8 EMD58482.1 - 3.7e-20 72.7 0.1 3.7e-20 72.7 0.1 3.9 3 1 1 4 4 4 1 Pre-mRNA splicing factor Cir_N PF10197.9 EMD58482.1 - 5.5e-13 48.9 10.1 5.5e-13 48.9 10.1 4.9 4 2 2 6 6 6 2 N-terminal domain of CBF1 interacting co-repressor CIR RRM_1 PF00076.22 EMD58483.1 - 1.5e-05 24.7 0.0 0.78 9.6 0.0 3.5 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MWFE PF15879.5 EMD58483.1 - 0.00054 20.1 0.3 0.0023 18.1 0.0 2.1 2 0 0 2 2 2 1 NADH-ubiquinone oxidoreductase MWFE subunit RRN3 PF05327.11 EMD58483.1 - 0.0026 16.4 3.5 0.0036 15.9 3.5 1.2 1 0 0 1 1 1 1 RNA polymerase I specific transcription initiation factor RRN3 CENP-B_dimeris PF09026.10 EMD58483.1 - 0.004 17.5 9.8 0.004 17.5 9.8 2.4 2 1 1 3 3 3 1 Centromere protein B dimerisation domain DUF702 PF05142.12 EMD58483.1 - 0.12 12.8 2.6 1 9.8 0.0 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF702) SYF2 PF08231.12 EMD58484.1 - 1.2e-45 155.8 15.0 1.2e-45 155.8 15.0 1.8 2 0 0 2 2 2 1 SYF2 splicing factor DUF4286 PF14114.6 EMD58484.1 - 0.12 12.9 2.0 7.6 7.1 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4286) AMP-binding PF00501.28 EMD58485.1 - 8.4e-77 258.5 0.0 1.3e-76 257.9 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme NAD_binding_4 PF07993.12 EMD58485.1 - 3.9e-62 209.7 0.0 1.1e-61 208.3 0.0 1.8 2 0 0 2 2 2 1 Male sterility protein adh_short PF00106.25 EMD58485.1 - 8.3e-50 169.0 2.0 2.1e-49 167.7 2.0 1.7 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD58485.1 - 6.6e-37 127.3 0.5 7e-36 123.9 0.3 2.1 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD58485.1 - 1e-15 58.1 1.8 2.5e-12 47.1 1.3 2.4 2 0 0 2 2 2 2 KR domain Epimerase PF01370.21 EMD58485.1 - 7.4e-14 51.8 0.1 3.7e-07 29.9 0.0 3.2 3 1 0 3 3 3 2 NAD dependent epimerase/dehydratase family PP-binding PF00550.25 EMD58485.1 - 3.3e-13 49.8 0.0 8.6e-13 48.4 0.0 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site 3Beta_HSD PF01073.19 EMD58485.1 - 1.4e-08 34.1 0.1 1.5e-05 24.1 0.0 3.0 2 1 0 2 2 2 2 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 EMD58485.1 - 1e-05 25.5 0.2 0.00022 21.2 0.3 2.6 2 0 0 2 2 2 1 NAD(P)H-binding Polysacc_synt_2 PF02719.15 EMD58485.1 - 0.00013 21.2 0.9 0.67 9.0 0.4 3.0 2 1 0 2 2 2 2 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 EMD58485.1 - 0.00025 20.2 0.3 0.027 13.6 0.0 2.9 2 1 0 2 2 2 1 RmlD substrate binding domain AMP-binding_C PF13193.6 EMD58485.1 - 0.00032 21.6 0.0 0.0031 18.5 0.0 2.8 3 0 0 3 3 3 1 AMP-binding enzyme C-terminal domain GDP_Man_Dehyd PF16363.5 EMD58485.1 - 0.0028 17.1 0.0 0.97 8.8 0.0 2.5 2 0 0 2 2 2 2 GDP-mannose 4,6 dehydratase THF_DHG_CYH_C PF02882.19 EMD58485.1 - 0.11 11.9 0.0 0.27 10.5 0.0 1.6 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Eno-Rase_NADH_b PF12242.8 EMD58485.1 - 0.2 11.4 0.5 0.57 10.0 0.5 1.7 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase FCH PF00611.23 EMD58486.1 - 1.3 9.3 4.0 3.1 8.1 0.1 3.4 4 0 0 4 4 4 0 Fes/CIP4, and EFC/F-BAR homology domain DUF2070 PF09843.9 EMD58487.1 - 6.9 4.8 6.8 9.2 4.4 6.8 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Pkinase PF00069.25 EMD58489.1 - 3.9e-35 121.5 0.9 3.9e-35 121.5 0.9 1.8 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD58489.1 - 1.2e-22 80.4 0.6 2.1e-22 79.7 0.6 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase C1_1 PF00130.22 EMD58489.1 - 8.8e-20 70.4 33.1 2.7e-12 46.4 10.8 2.3 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) HR1 PF02185.16 EMD58489.1 - 1.5e-16 60.3 4.4 3.6e-16 59.0 4.4 1.7 1 0 0 1 1 1 1 Hr1 repeat C2 PF00168.30 EMD58489.1 - 0.0013 19.0 0.0 0.0023 18.2 0.0 1.3 1 0 0 1 1 1 1 C2 domain FTA2 PF13095.6 EMD58489.1 - 0.026 14.1 0.1 0.26 10.9 0.1 2.1 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Uds1 PF15456.6 EMD58489.1 - 0.4 10.9 3.3 0.14 12.3 0.3 1.7 2 0 0 2 2 2 0 Up-regulated During Septation AMP-binding PF00501.28 EMD58490.1 - 9.5e-77 258.4 0.0 1.2e-76 258.0 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EMD58490.1 - 2.5e-05 25.1 0.0 4.6e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Kin17_mid PF10357.9 EMD58491.1 - 9.4e-45 151.6 1.1 9.4e-45 151.6 1.1 1.8 1 1 1 2 2 2 1 Domain of Kin17 curved DNA-binding protein zf-met PF12874.7 EMD58491.1 - 0.00082 19.7 3.9 0.0018 18.6 3.9 1.6 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EMD58491.1 - 0.023 15.0 2.4 0.053 13.8 2.4 1.7 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding TFIID_NTD2 PF04494.15 EMD58491.1 - 0.028 14.6 0.2 0.055 13.7 0.2 1.5 1 0 0 1 1 1 0 WD40 associated region in TFIID subunit, NTD2 domain GvpL_GvpF PF06386.11 EMD58491.1 - 0.061 13.2 5.1 0.09 12.7 5.1 1.2 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF zf-C2H2_2 PF12756.7 EMD58491.1 - 0.14 12.5 0.2 0.14 12.5 0.2 2.4 2 1 0 2 2 2 0 C2H2 type zinc-finger (2 copies) Presenilin PF01080.17 EMD58491.1 - 7.8 5.1 6.3 11 4.7 6.3 1.1 1 0 0 1 1 1 0 Presenilin Band_7 PF01145.25 EMD58492.1 - 1.1e-30 106.9 0.5 1.1e-30 106.9 0.5 1.8 2 0 0 2 2 2 1 SPFH domain / Band 7 family Band_7_C PF16200.5 EMD58492.1 - 2.5e-24 85.1 2.2 7.1e-24 83.6 2.2 1.9 1 0 0 1 1 1 1 C-terminal region of band_7 DUF3072 PF11272.8 EMD58492.1 - 0.006 16.4 0.2 0.032 14.1 0.2 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF3072) Pox_A11 PF05061.13 EMD58492.1 - 0.017 14.4 0.2 0.03 13.6 0.2 1.5 1 0 0 1 1 1 0 Poxvirus A11 Protein NleF_casp_inhib PF16809.5 EMD58492.1 - 0.029 14.3 2.0 0.42 10.5 0.2 2.5 2 1 0 2 2 2 0 NleF caspase inhibitor Band_7_1 PF13421.6 EMD58492.1 - 0.048 13.4 0.3 0.1 12.3 0.0 1.7 2 0 0 2 2 2 0 SPFH domain-Band 7 family Vps51 PF08700.11 EMD58492.1 - 0.45 10.6 2.6 29 4.8 0.3 3.1 3 0 0 3 3 3 0 Vps51/Vps67 Abhydrolase_3 PF07859.13 EMD58493.1 - 0.00025 20.9 0.1 0.082 12.7 0.0 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold DUF3089 PF11288.8 EMD58493.1 - 0.016 14.8 0.0 0.022 14.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3089) Hydrolase_4 PF12146.8 EMD58493.1 - 0.031 13.5 0.0 0.1 11.8 0.0 1.8 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Say1_Mug180 PF10340.9 EMD58493.1 - 0.19 10.5 0.0 0.44 9.3 0.0 1.5 1 1 0 1 1 1 0 Steryl acetyl hydrolase CBF PF03914.17 EMD58495.1 - 3.1e-57 193.3 2.2 4.4e-57 192.8 0.7 2.1 2 0 0 2 2 2 1 CBF/Mak21 family BUD22 PF09073.10 EMD58495.1 - 0.0028 17.1 14.3 0.0028 17.1 14.3 3.2 4 0 0 4 4 4 1 BUD22 Cnd1 PF12717.7 EMD58495.1 - 0.0097 16.0 0.4 0.081 13.0 0.1 2.3 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 DNA_alkylation PF08713.11 EMD58495.1 - 0.024 14.4 1.9 1.6 8.4 0.5 2.5 2 0 0 2 2 2 0 DNA alkylation repair enzyme PcrB PF01884.17 EMD58495.1 - 0.12 11.8 0.1 0.2 11.1 0.1 1.3 1 0 0 1 1 1 0 PcrB family CTK3 PF12243.8 EMD58495.1 - 0.36 10.8 3.6 3.6 7.6 0.1 3.4 2 1 2 4 4 4 0 CTD kinase subunit gamma CTK3 Glycos_transf_3 PF00591.21 EMD58496.1 - 5.5e-61 206.4 0.0 7.9e-61 205.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family, a/b domain Glycos_trans_3N PF02885.17 EMD58496.1 - 5.2e-11 42.2 0.0 1.6e-10 40.6 0.0 1.8 2 0 0 2 2 2 1 Glycosyl transferase family, helical bundle domain zf-C2H2 PF00096.26 EMD58499.1 - 1e-06 28.8 8.0 2.2e-05 24.7 1.5 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMD58499.1 - 2.7e-05 24.4 2.4 2.7e-05 24.4 2.4 3.5 3 1 0 3 3 3 1 Zinc-finger double domain zf-C2H2_6 PF13912.6 EMD58499.1 - 0.00047 20.1 1.0 0.0015 18.5 0.3 2.2 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_4 PF13894.6 EMD58499.1 - 0.0076 17.0 0.8 0.0076 17.0 0.8 3.1 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EMD58499.1 - 0.01 16.1 0.7 0.027 14.8 0.7 1.7 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EMD58499.1 - 0.24 11.8 0.4 0.24 11.8 0.4 2.2 2 0 0 2 2 2 0 Zinc-finger of C2H2 type ATP_bind_1 PF03029.17 EMD58500.1 - 3.6e-64 216.9 0.0 1.2e-62 211.9 0.0 2.8 1 1 0 1 1 1 1 Conserved hypothetical ATP binding protein GTP_EFTU PF00009.27 EMD58500.1 - 3e-05 23.6 0.0 0.0091 15.5 0.0 3.0 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EMD58500.1 - 0.00014 21.9 0.0 0.36 10.9 0.0 2.3 2 0 0 2 2 2 2 50S ribosome-binding GTPase Arf PF00025.21 EMD58500.1 - 0.00018 21.0 0.0 0.2 11.1 0.0 3.3 3 0 0 3 3 3 1 ADP-ribosylation factor family FeoB_N PF02421.18 EMD58500.1 - 0.00089 18.8 0.0 0.052 13.1 0.0 2.7 3 0 0 3 3 3 1 Ferrous iron transport protein B Roc PF08477.13 EMD58500.1 - 0.00091 19.4 0.0 0.29 11.4 0.0 2.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase AAA_22 PF13401.6 EMD58500.1 - 0.0011 19.2 0.0 0.0035 17.6 0.0 1.8 1 0 0 1 1 1 1 AAA domain MeaB PF03308.16 EMD58500.1 - 0.0011 18.0 0.0 0.081 11.9 0.0 2.2 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB NACHT PF05729.12 EMD58500.1 - 0.0031 17.4 0.0 0.0065 16.4 0.0 1.4 1 0 0 1 1 1 1 NACHT domain G-alpha PF00503.20 EMD58500.1 - 0.0072 15.5 0.0 0.14 11.2 0.0 2.2 2 0 0 2 2 2 1 G-protein alpha subunit AAA_33 PF13671.6 EMD58500.1 - 0.01 16.0 0.0 0.01 16.0 0.0 1.8 2 0 0 2 2 1 0 AAA domain SRPRB PF09439.10 EMD58500.1 - 0.011 15.2 0.0 0.83 9.1 0.0 2.2 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit Ras PF00071.22 EMD58500.1 - 0.011 15.3 0.0 2.9 7.4 0.0 2.6 3 0 0 3 3 3 0 Ras family RsgA_GTPase PF03193.16 EMD58500.1 - 0.013 15.5 0.1 11 5.9 0.0 3.1 3 0 0 3 3 3 0 RsgA GTPase cobW PF02492.19 EMD58500.1 - 0.014 15.0 0.1 0.93 9.1 0.0 2.4 2 1 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_30 PF13604.6 EMD58500.1 - 0.015 15.0 0.0 0.031 14.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EMD58500.1 - 0.019 15.4 0.0 0.047 14.1 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain NB-ARC PF00931.22 EMD58500.1 - 0.027 13.6 0.0 0.065 12.4 0.0 1.6 1 0 0 1 1 1 0 NB-ARC domain AAA_24 PF13479.6 EMD58500.1 - 0.033 13.9 0.0 0.063 13.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain Pox_A32 PF04665.12 EMD58500.1 - 0.033 13.6 0.0 0.09 12.2 0.0 1.7 2 0 0 2 2 2 0 Poxvirus A32 protein RNA_helicase PF00910.22 EMD58500.1 - 0.035 14.5 0.0 0.17 12.3 0.0 2.1 2 0 0 2 2 2 0 RNA helicase MobB PF03205.14 EMD58500.1 - 0.039 13.9 0.0 0.14 12.0 0.0 1.9 2 0 0 2 2 1 0 Molybdopterin guanine dinucleotide synthesis protein B SRP54 PF00448.22 EMD58500.1 - 0.055 13.1 0.0 0.48 10.0 0.0 2.2 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain DUF87 PF01935.17 EMD58500.1 - 0.056 13.5 0.3 0.61 10.1 0.0 2.2 2 0 0 2 2 2 0 Helicase HerA, central domain Asn_synthase PF00733.21 EMD58500.1 - 0.057 13.1 0.2 0.097 12.3 0.2 1.3 1 0 0 1 1 1 0 Asparagine synthase PRK PF00485.18 EMD58500.1 - 0.073 12.8 0.1 1.6 8.4 0.0 2.2 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family Viral_helicase1 PF01443.18 EMD58500.1 - 0.13 12.0 0.0 0.23 11.2 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_18 PF13238.6 EMD58500.1 - 0.26 11.9 1.3 0.36 11.4 0.0 1.9 2 0 0 2 2 1 0 AAA domain CwfJ_C_1 PF04677.15 EMD58501.1 - 4.7e-27 94.3 0.0 4.6e-26 91.1 0.0 2.1 2 0 0 2 2 2 1 Protein similar to CwfJ C-terminus 1 CwfJ_C_2 PF04676.14 EMD58501.1 - 1.7e-24 86.5 0.2 1.7e-24 86.5 0.2 3.0 3 1 0 3 3 3 1 Protein similar to CwfJ C-terminus 2 FumaraseC_C PF10415.9 EMD58501.1 - 0.19 12.2 0.5 39 4.8 0.1 2.8 2 0 0 2 2 2 0 Fumarase C C-terminus CorA PF01544.18 EMD58502.1 - 7e-09 35.4 2.2 4.3e-08 32.8 0.3 2.7 2 0 0 2 2 2 1 CorA-like Mg2+ transporter protein CDH1_2_SANT_HL1 PF18375.1 EMD58502.1 - 0.091 13.4 0.1 46 4.8 0.1 3.2 2 0 0 2 2 2 0 CDH1/2 SANT-Helical linker 1 Rad60-SLD_2 PF13881.6 EMD58504.1 - 3.8e-13 49.5 0.1 7e-13 48.7 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 EMD58504.1 - 0.00066 20.2 0.0 0.0012 19.4 0.0 1.4 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain ubiquitin PF00240.23 EMD58504.1 - 0.00092 18.9 0.0 0.0016 18.1 0.0 1.5 1 1 0 1 1 1 1 Ubiquitin family DUF92 PF01940.16 EMD58505.1 - 8.2e-84 280.7 8.8 1.1e-83 280.3 8.8 1.2 1 0 0 1 1 1 1 Integral membrane protein DUF92 UMP1 PF05348.11 EMD58505.1 - 3.3e-40 137.0 0.0 6.2e-40 136.1 0.0 1.5 1 0 0 1 1 1 1 Proteasome maturation factor UMP1 adh_short PF00106.25 EMD58506.1 - 3e-21 75.8 0.0 4e-21 75.4 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD58506.1 - 3.3e-15 56.3 0.0 4.4e-15 55.9 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD58506.1 - 3.6e-10 40.0 0.0 4.6e-10 39.7 0.0 1.1 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 EMD58506.1 - 4.7e-05 23.4 0.1 6.6e-05 22.9 0.1 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EMD58506.1 - 0.00014 21.4 0.0 0.00024 20.7 0.0 1.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 EMD58506.1 - 0.0019 17.8 0.0 0.0027 17.3 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family GDP_Man_Dehyd PF16363.5 EMD58506.1 - 0.011 15.2 0.1 0.069 12.5 0.1 2.3 1 1 0 1 1 1 0 GDP-mannose 4,6 dehydratase p450 PF00067.22 EMD58507.1 - 6.1e-35 120.9 0.0 3.8e-30 105.0 0.0 2.1 2 0 0 2 2 2 2 Cytochrome P450 Aim19 PF10315.9 EMD58509.1 - 0.087 13.1 0.4 0.13 12.6 0.4 1.2 1 0 0 1 1 1 0 Altered inheritance of mitochondria protein 19 HET PF06985.11 EMD58510.1 - 0.036 14.4 0.0 0.049 14.0 0.0 1.2 1 0 0 1 1 1 0 Heterokaryon incompatibility protein (HET) p450 PF00067.22 EMD58511.1 - 7.2e-10 38.2 0.1 7.6e-10 38.1 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 Amidohydro_2 PF04909.14 EMD58512.1 - 7.2e-07 29.3 0.0 8.1e-07 29.1 0.0 1.0 1 0 0 1 1 1 1 Amidohydrolase FAD_binding_4 PF01565.23 EMD58513.1 - 6.1e-20 71.4 5.5 1.2e-19 70.5 5.5 1.4 1 0 0 1 1 1 1 FAD binding domain MMR_HSR1 PF01926.23 EMD58514.1 - 7e-06 26.1 0.0 1.6e-05 24.9 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.16 EMD58514.1 - 0.0004 19.8 0.0 0.00077 18.8 0.0 1.5 1 0 0 1 1 1 1 AIG1 family CmlA_N PF18456.1 EMD58514.1 - 0.04 13.2 0.2 0.096 12.0 0.2 1.7 1 0 0 1 1 1 0 Diiron non-heme beta-hydroxylase N-terminal domain Dynamin_N PF00350.23 EMD58514.1 - 0.041 13.9 4.3 2.1 8.4 0.0 3.4 2 2 1 3 3 3 0 Dynamin family RsgA_GTPase PF03193.16 EMD58514.1 - 0.42 10.5 2.3 1.1 9.1 0.4 2.4 2 1 0 2 2 2 0 RsgA GTPase MMR_HSR1 PF01926.23 EMD58515.1 - 1.8e-19 69.9 1.5 7.9e-09 35.6 0.0 3.7 3 0 0 3 3 3 2 50S ribosome-binding GTPase FeoB_N PF02421.18 EMD58515.1 - 2.5e-08 33.6 0.1 0.00064 19.3 0.0 2.7 2 0 0 2 2 2 2 Ferrous iron transport protein B Septin PF00735.18 EMD58515.1 - 4e-08 32.9 0.1 0.0073 15.6 0.0 3.1 2 0 0 2 2 2 2 Septin RsgA_GTPase PF03193.16 EMD58515.1 - 9.2e-08 32.2 1.4 0.0021 18.0 0.1 3.1 2 1 0 2 2 2 2 RsgA GTPase AIG1 PF04548.16 EMD58515.1 - 1e-07 31.5 0.2 0.00032 20.1 0.0 3.6 4 0 0 4 4 3 2 AIG1 family AAA_22 PF13401.6 EMD58515.1 - 3.1e-06 27.5 2.0 0.099 12.9 0.0 3.4 3 0 0 3 3 3 2 AAA domain NB-ARC PF00931.22 EMD58515.1 - 0.00013 21.2 1.4 0.17 11.0 0.0 3.4 3 1 1 4 4 4 2 NB-ARC domain SRPRB PF09439.10 EMD58515.1 - 0.00038 19.9 0.0 0.033 13.6 0.0 4.0 5 0 0 5 5 4 2 Signal recognition particle receptor beta subunit AAA_24 PF13479.6 EMD58515.1 - 0.00047 19.9 0.2 0.51 10.0 0.0 3.2 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.27 EMD58515.1 - 0.00067 20.2 13.2 0.64 10.5 0.0 4.9 4 0 0 4 4 4 2 ABC transporter IIGP PF05049.13 EMD58515.1 - 0.0014 17.8 2.8 0.24 10.4 0.0 3.3 3 0 0 3 3 3 1 Interferon-inducible GTPase (IIGP) Viral_helicase1 PF01443.18 EMD58515.1 - 0.0015 18.3 0.2 2.5 7.8 0.1 2.9 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase MeaB PF03308.16 EMD58515.1 - 0.0038 16.2 0.0 0.69 8.8 0.0 3.0 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_14 PF13173.6 EMD58515.1 - 0.0045 17.0 0.0 1.3 9.1 0.0 3.5 2 0 0 2 2 2 1 AAA domain TsaE PF02367.17 EMD58515.1 - 0.0047 16.9 0.1 4.8 7.2 0.0 2.6 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE Arf PF00025.21 EMD58515.1 - 0.0069 15.9 0.0 0.18 11.3 0.0 2.8 2 0 0 2 2 2 1 ADP-ribosylation factor family AAA_29 PF13555.6 EMD58515.1 - 0.0096 15.6 0.9 0.26 11.1 0.3 2.4 2 0 0 2 2 2 1 P-loop containing region of AAA domain Gtr1_RagA PF04670.12 EMD58515.1 - 0.019 14.3 0.0 1.8 7.9 0.0 3.1 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region AAA_18 PF13238.6 EMD58515.1 - 0.02 15.4 20.2 1.7 9.2 0.0 5.0 4 1 0 4 4 4 0 AAA domain SRP54 PF00448.22 EMD58515.1 - 0.026 14.1 3.0 2.7 7.6 0.1 3.1 2 1 0 2 2 2 0 SRP54-type protein, GTPase domain T2SSE PF00437.20 EMD58515.1 - 0.034 13.2 7.3 0.17 10.9 0.1 3.1 3 0 0 3 3 3 0 Type II/IV secretion system protein FtsK_SpoIIIE PF01580.18 EMD58515.1 - 0.042 13.2 1.2 5.2 6.3 0.1 3.8 4 0 0 4 4 4 0 FtsK/SpoIIIE family RNA_helicase PF00910.22 EMD58515.1 - 0.1 13.0 4.6 10 6.5 0.0 3.7 3 0 0 3 3 3 0 RNA helicase Dynamin_N PF00350.23 EMD58515.1 - 0.14 12.2 0.0 0.58 10.2 0.0 7.2 5 4 2 7 7 6 0 Dynamin family AAA_25 PF13481.6 EMD58515.1 - 0.21 11.1 2.2 9.8 5.7 0.0 3.3 3 0 0 3 3 3 0 AAA domain AAA_16 PF13191.6 EMD58515.1 - 1.2 9.5 0.0 1.2 9.5 0.0 4.2 4 1 1 5 5 4 0 AAA ATPase domain G-alpha PF00503.20 EMD58515.1 - 2.8 7.0 17.3 0.47 9.6 0.6 4.9 3 1 2 5 5 5 0 G-protein alpha subunit GTP_EFTU PF00009.27 EMD58515.1 - 3.5 7.1 13.1 6.6 6.2 0.7 4.8 3 3 1 4 4 4 0 Elongation factor Tu GTP binding domain dNK PF01712.19 EMD58515.1 - 9.8 6.0 15.5 3.5 7.4 0.1 4.1 4 0 0 4 4 4 0 Deoxynucleoside kinase GFO_IDH_MocA PF01408.22 EMD58516.1 - 8.2e-20 71.8 0.0 1.4e-19 71.1 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold MFS_1 PF07690.16 EMD58517.1 - 8.2e-28 97.3 37.3 8.2e-28 97.3 37.3 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily ATG27 PF09451.10 EMD58518.1 - 6.2e-89 298.4 0.0 7.5e-89 298.1 0.0 1.0 1 0 0 1 1 1 1 Autophagy-related protein 27 CIMR PF00878.18 EMD58518.1 - 0.00091 19.3 0.4 3.7 7.6 0.0 3.2 3 0 0 3 3 3 2 Cation-independent mannose-6-phosphate receptor repeat DUF4687 PF15747.5 EMD58520.1 - 0.0059 17.1 2.2 0.0059 17.1 2.2 1.9 1 1 1 2 2 2 1 Domain of unknown function (DUF4687) ADH_zinc_N PF00107.26 EMD58521.1 - 5.4e-12 45.8 0.1 1.3e-11 44.6 0.1 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EMD58521.1 - 2.7e-07 30.4 0.0 4.9e-07 29.6 0.0 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 EMD58521.1 - 0.00013 23.0 0.0 0.0006 20.9 0.0 2.1 1 1 0 1 1 1 1 Zinc-binding dehydrogenase Epimerase PF01370.21 EMD58521.1 - 0.0019 17.7 0.0 0.0028 17.2 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF2303 PF10065.9 EMD58521.1 - 0.011 14.9 0.0 0.016 14.4 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2303) AlaDh_PNT_C PF01262.21 EMD58521.1 - 0.028 13.7 0.3 0.046 13.0 0.3 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain DapB_N PF01113.20 EMD58521.1 - 0.062 13.4 0.4 4 7.6 0.1 2.4 2 0 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus TctC PF03401.14 EMD58521.1 - 0.086 11.9 0.1 0.15 11.1 0.1 1.4 1 0 0 1 1 1 0 Tripartite tricarboxylate transporter family receptor ELFV_dehydrog PF00208.21 EMD58521.1 - 0.099 12.3 0.4 0.19 11.5 0.1 1.6 2 0 0 2 2 2 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Con-6 PF10346.9 EMD58522.1 - 2.2e-35 120.4 6.1 3.7e-18 65.2 0.8 2.3 2 0 0 2 2 2 2 Conidiation protein 6 SpoIIIAH PF12685.7 EMD58522.1 - 0.035 13.9 4.6 0.82 9.5 0.4 2.2 1 1 1 2 2 2 0 SpoIIIAH-like protein PAC4 PF16093.5 EMD58523.1 - 2.4e-21 75.7 0.1 3.3e-21 75.2 0.1 1.2 1 0 0 1 1 1 1 Proteasome assembly chaperone 4 N2227 PF07942.12 EMD58524.1 - 3.2e-86 288.9 0.0 4.3e-86 288.5 0.0 1.1 1 0 0 1 1 1 1 N2227-like protein Methyltransf_11 PF08241.12 EMD58524.1 - 0.0036 17.9 0.0 0.17 12.6 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EMD58524.1 - 0.019 14.8 0.0 0.029 14.2 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.12 EMD58524.1 - 0.041 14.6 0.0 0.2 12.4 0.0 2.1 1 1 0 1 1 1 0 Methyltransferase domain PSII_Pbs27 PF13326.6 EMD58524.1 - 0.15 12.3 0.0 0.29 11.5 0.0 1.5 1 0 0 1 1 1 0 Photosystem II Pbs27 LSM PF01423.22 EMD58526.1 - 2.9e-20 71.7 0.2 3.6e-20 71.4 0.2 1.1 1 0 0 1 1 1 1 LSM domain FoP_duplication PF13865.6 EMD58526.1 - 0.0015 19.0 11.7 0.0024 18.4 11.7 1.3 1 0 0 1 1 1 1 C-terminal duplication domain of Friend of PRMT1 Zn_clus PF00172.18 EMD58527.1 - 0.026 14.7 9.0 0.056 13.6 9.0 1.6 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Cupin_2 PF07883.11 EMD58528.1 - 2.3e-16 59.3 0.5 3.2e-16 58.8 0.5 1.2 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.19 EMD58528.1 - 0.0078 16.1 0.0 0.012 15.6 0.0 1.3 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_1 PF00190.22 EMD58528.1 - 0.051 13.2 0.1 0.08 12.6 0.1 1.3 1 0 0 1 1 1 0 Cupin Peptidase_C12 PF01088.21 EMD58529.1 - 1.6e-46 158.8 0.0 1.9e-46 158.5 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 p450 PF00067.22 EMD58530.1 - 6.9e-41 140.5 0.0 8e-41 140.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Esterase_phd PF10503.9 EMD58531.1 - 6.7e-20 71.5 0.1 8.9e-20 71.1 0.1 1.1 1 0 0 1 1 1 1 Esterase PHB depolymerase Peptidase_S9 PF00326.21 EMD58531.1 - 5.7e-08 32.5 0.4 1.6e-07 31.0 0.4 1.8 1 1 0 1 1 1 1 Prolyl oligopeptidase family FSH1 PF03959.13 EMD58531.1 - 0.0099 15.6 0.0 0.02 14.6 0.0 1.6 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_2 PF02230.16 EMD58531.1 - 0.019 14.8 0.0 0.13 12.0 0.1 2.2 2 1 0 2 2 2 0 Phospholipase/Carboxylesterase Abhydrolase_3 PF07859.13 EMD58531.1 - 0.027 14.3 0.1 0.053 13.4 0.1 1.4 1 1 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_1 PF00561.20 EMD58531.1 - 0.054 13.1 1.1 0.22 11.1 1.1 1.9 1 1 1 2 2 2 0 alpha/beta hydrolase fold Eno-Rase_NADH_b PF12242.8 EMD58531.1 - 0.11 12.2 0.0 0.35 10.6 0.0 1.8 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Esterase PF00756.20 EMD58531.1 - 0.11 12.1 0.1 0.14 11.7 0.1 1.3 1 0 0 1 1 1 0 Putative esterase BAAT_C PF08840.11 EMD58531.1 - 0.12 12.3 0.1 0.21 11.5 0.1 1.4 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal p450 PF00067.22 EMD58532.1 - 2e-44 152.2 0.0 2.3e-44 151.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Sulfotransfer_3 PF13469.6 EMD58535.1 - 0.0006 20.2 0.8 0.66 10.3 0.0 3.1 3 1 0 3 3 3 2 Sulfotransferase family OST3_OST6 PF04756.13 EMD58536.1 - 0.0034 16.8 0.0 0.0069 15.8 0.0 1.4 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Claudin_2 PF13903.6 EMD58536.1 - 0.095 12.4 3.4 0.1 12.3 2.4 1.6 1 1 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction HET PF06985.11 EMD58537.1 - 2.9e-25 89.3 0.9 3.7e-25 89.0 0.9 1.1 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) HeLo PF14479.6 EMD58538.1 - 9.6e-06 25.6 0.4 1.2e-05 25.2 0.4 1.2 1 0 0 1 1 1 1 Prion-inhibition and propagation HeLo PF14479.6 EMD58539.1 - 1.6e-07 31.4 0.1 2.3e-07 30.9 0.1 1.3 1 0 0 1 1 1 1 Prion-inhibition and propagation HET PF06985.11 EMD58540.1 - 3e-30 105.5 0.2 5.5e-30 104.7 0.2 1.5 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) HET PF06985.11 EMD58541.1 - 1.8e-34 119.2 0.1 3.5e-34 118.3 0.1 1.5 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) FAD_binding_9 PF08021.11 EMD58544.1 - 0.056 13.6 0.0 0.1 12.8 0.0 1.4 1 0 0 1 1 1 0 Siderophore-interacting FAD-binding domain Glyco_hydro_3_C PF01915.22 EMD58545.1 - 6.5e-42 143.8 0.0 9.7e-42 143.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 EMD58545.1 - 1e-33 117.1 0.0 1.7e-33 116.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 EMD58545.1 - 1.8e-21 76.0 0.0 3.2e-21 75.2 0.0 1.4 1 0 0 1 1 1 1 Fibronectin type III-like domain HEAT_2 PF13646.6 EMD58546.1 - 1.3e-09 38.3 0.9 0.002 18.5 0.2 2.9 1 1 2 3 3 3 3 HEAT repeats HEAT PF02985.22 EMD58546.1 - 2.7e-07 30.3 0.0 0.087 13.1 0.0 4.8 5 0 0 5 5 5 1 HEAT repeat DNA_alkylation PF08713.11 EMD58546.1 - 0.0013 18.5 0.9 4.5 6.9 0.1 3.4 2 2 1 3 3 3 2 DNA alkylation repair enzyme HEAT_EZ PF13513.6 EMD58546.1 - 0.0017 18.8 0.5 0.63 10.6 0.0 3.5 4 1 0 4 4 4 1 HEAT-like repeat RTP1_C1 PF10363.9 EMD58546.1 - 0.0031 17.7 0.1 1.1 9.4 0.0 3.2 1 1 1 2 2 2 1 Required for nuclear transport of RNA pol II C-terminus 1 NTP_transf_3 PF12804.7 EMD58546.1 - 0.018 15.4 0.5 4.5 7.6 0.0 2.5 1 1 1 2 2 2 0 MobA-like NTP transferase domain Cnd1 PF12717.7 EMD58546.1 - 0.043 13.9 0.0 3.6 7.6 0.0 2.7 1 1 2 3 3 3 0 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 EMD58546.1 - 0.088 11.3 0.1 6.5 5.2 0.0 2.0 1 1 0 2 2 2 0 Adaptin N terminal region PI-PLC-C1 PF16670.5 EMD58547.1 - 1.9e-125 418.3 0.0 2.1e-125 418.2 0.0 1.0 1 0 0 1 1 1 1 Phosphoinositide phospholipase C, Ca2+-dependent AbiEi_4 PF13338.6 EMD58547.1 - 0.11 12.6 0.1 1.2 9.4 0.0 2.5 2 0 0 2 2 2 0 Transcriptional regulator, AbiEi antitoxin Asp PF00026.23 EMD58549.1 - 6.2e-32 111.3 0.1 9.2e-32 110.7 0.1 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EMD58549.1 - 0.021 15.1 0.0 0.041 14.1 0.0 1.5 1 0 0 1 1 1 0 Xylanase inhibitor N-terminal Sugar_tr PF00083.24 EMD58550.1 - 1.6e-87 294.3 22.2 1.9e-87 294.0 22.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD58550.1 - 1.4e-17 63.7 27.8 1.9e-17 63.3 23.6 2.2 2 1 0 2 2 2 2 Major Facilitator Superfamily PP2C PF00481.21 EMD58556.1 - 1.6e-35 123.0 0.1 9.9e-30 104.0 0.0 2.2 2 0 0 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.6 EMD58556.1 - 0.0017 18.0 0.0 0.0043 16.7 0.0 1.6 1 1 0 1 1 1 1 Protein phosphatase 2C HEAT PF02985.22 EMD58558.1 - 1.5e-13 49.7 9.1 0.00011 22.2 0.0 8.8 9 0 0 9 9 9 2 HEAT repeat HEAT_EZ PF13513.6 EMD58558.1 - 6.8e-12 45.6 14.4 4.8e-08 33.3 0.0 8.4 6 2 3 9 9 9 1 HEAT-like repeat IBN_N PF03810.19 EMD58558.1 - 4.2e-10 39.4 3.1 2.1e-08 34.0 0.4 3.6 3 0 0 3 3 3 1 Importin-beta N-terminal domain HEAT_2 PF13646.6 EMD58558.1 - 4.1e-09 36.7 5.7 0.011 16.1 0.0 7.1 4 1 3 7 7 7 3 HEAT repeats CLASP_N PF12348.8 EMD58558.1 - 2.9e-07 30.3 0.0 0.046 13.3 0.0 4.4 3 1 2 5 5 5 2 CLASP N terminal RIX1 PF08167.12 EMD58558.1 - 0.0002 21.2 0.1 2 8.1 0.0 4.3 3 1 1 4 4 4 1 rRNA processing/ribosome biogenesis DUF3385 PF11865.8 EMD58558.1 - 0.00045 20.2 0.2 1.1 9.1 0.4 4.3 4 1 0 5 5 5 1 Domain of unknown function (DUF3385) Arm PF00514.23 EMD58558.1 - 0.0017 18.3 5.1 0.57 10.3 0.0 5.6 6 0 0 6 6 6 1 Armadillo/beta-catenin-like repeat DUF4487 PF14868.6 EMD58558.1 - 0.084 11.7 0.0 0.24 10.2 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4487) CLIP PF12032.8 EMD58558.1 - 0.095 13.0 0.1 36 4.7 0.0 3.1 3 0 0 3 3 3 0 Regulatory CLIP domain of proteinases HEAT_PBS PF03130.16 EMD58558.1 - 2.8 8.9 8.0 25 5.9 0.1 5.9 6 0 0 6 6 6 0 PBS lyase HEAT-like repeat Cation_efflux PF01545.21 EMD58559.1 - 2e-19 70.1 7.3 2.6e-19 69.8 7.3 1.1 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 EMD58559.1 - 3.1e-10 40.0 0.6 7.6e-10 38.8 0.6 1.6 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter GrpE PF01025.19 EMD58559.1 - 0.075 12.7 0.1 0.15 11.7 0.1 1.3 1 0 0 1 1 1 0 GrpE Fungal_trans PF04082.18 EMD58560.1 - 2.3e-25 89.1 0.1 5.2e-25 88.0 0.1 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD58560.1 - 1.5e-07 31.4 7.7 3.1e-07 30.4 7.7 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Mannosidase_ig PF17786.1 EMD58561.1 - 8.8e-19 67.9 0.3 2.6e-18 66.4 0.3 1.9 1 0 0 1 1 1 1 Mannosidase Ig/CBM-like domain Glyco_hydro_2 PF00703.21 EMD58561.1 - 1.5e-10 41.7 0.1 7e-10 39.6 0.0 2.1 2 0 0 2 2 2 1 Glycosyl hydrolases family 2 Glyco_hydro_2_N PF02837.18 EMD58561.1 - 0.028 14.3 0.1 0.15 11.9 0.0 2.2 3 0 0 3 3 3 0 Glycosyl hydrolases family 2, sugar binding domain Thaumatin PF00314.17 EMD58562.1 - 3.3e-70 236.1 2.6 4.9e-70 235.5 2.6 1.3 1 0 0 1 1 1 1 Thaumatin family Glyco_hydro_64 PF16483.5 EMD58562.1 - 0.019 14.2 0.0 0.14 11.5 0.0 2.0 2 0 0 2 2 2 0 Beta-1,3-glucanase Cyt-b5 PF00173.28 EMD58563.1 - 3.5e-18 65.5 2.3 5.1e-18 65.0 0.0 2.3 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain FA_hydroxylase PF04116.13 EMD58563.1 - 8.1e-13 48.9 20.5 1.6e-12 47.9 20.5 1.5 1 0 0 1 1 1 1 Fatty acid hydroxylase superfamily Anth_synt_I_N PF04715.13 EMD58563.1 - 0.004 17.4 0.0 0.008 16.4 0.0 1.5 1 0 0 1 1 1 1 Anthranilate synthase component I, N terminal region COX14 PF14880.6 EMD58563.1 - 0.044 13.6 1.1 0.1 12.4 0.6 1.9 2 0 0 2 2 2 0 Cytochrome oxidase c assembly RRM_1 PF00076.22 EMD58564.1 - 2.4e-46 155.4 1.0 1.4e-20 72.8 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RBM39linker PF15519.6 EMD58564.1 - 2.5e-14 54.1 0.0 8.3e-14 52.5 0.0 1.9 1 0 0 1 1 1 1 linker between RRM2 and RRM3 domains in RBM39 protein RRM_occluded PF16842.5 EMD58564.1 - 3.3e-08 33.3 0.0 0.053 13.4 0.0 3.6 3 1 0 3 3 3 3 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 EMD58564.1 - 0.003 17.5 0.0 0.37 10.8 0.0 3.0 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif PHM7_cyt PF14703.6 EMD58564.1 - 0.011 16.0 0.0 0.15 12.3 0.0 2.7 2 1 0 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter RRM_5 PF13893.6 EMD58564.1 - 0.057 13.0 0.0 0.71 9.5 0.0 2.2 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EMD58564.1 - 0.14 12.3 0.0 2.2 8.5 0.0 2.4 2 0 0 2 2 2 0 RNA recognition motif TruD PF01142.18 EMD58565.1 - 6.5e-58 196.5 1.5 1.8e-53 181.9 0.5 3.8 2 1 0 2 2 2 2 tRNA pseudouridine synthase D (TruD) DUF3881 PF12997.7 EMD58565.1 - 0.047 12.9 0.6 0.08 12.2 0.6 1.3 1 0 0 1 1 1 0 Domain of unknown function, E. rectale Gene description (DUF3881) FtsK_4TM PF13491.6 EMD58566.1 - 0.023 14.4 0.4 0.029 14.1 0.4 1.0 1 0 0 1 1 1 0 4TM region of DNA translocase FtsK/SpoIIIE PHD PF00628.29 EMD58567.1 - 1.2e-08 34.7 4.4 2e-08 34.0 4.4 1.4 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 EMD58567.1 - 0.0022 17.5 3.2 0.0035 16.9 3.2 1.3 1 0 0 1 1 1 1 PHD-finger C1_1 PF00130.22 EMD58567.1 - 0.1 12.5 0.5 0.2 11.6 0.5 1.4 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) PHD_3 PF13922.6 EMD58567.1 - 0.23 11.9 1.2 0.91 10.0 1.2 2.1 1 0 0 1 1 1 0 PHD domain of transcriptional enhancer, Asx Herpes_gE PF02480.16 EMD58568.1 - 0.0002 20.3 0.1 0.00037 19.4 0.1 1.4 1 0 0 1 1 1 1 Alphaherpesvirus glycoprotein E EphA2_TM PF14575.6 EMD58568.1 - 0.017 16.0 0.0 0.037 14.9 0.0 1.7 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF4448 PF14610.6 EMD58568.1 - 0.096 12.5 0.3 0.16 11.7 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF4448) Insulin_TMD PF17870.1 EMD58568.1 - 0.62 10.2 2.7 5.2 7.2 0.2 2.3 2 0 0 2 2 2 0 Insulin receptor trans-membrane segment AIM3 PF17096.5 EMD58569.1 - 6.4e-06 27.0 1.5 6.4e-06 27.0 1.5 5.3 5 1 0 5 5 5 1 Altered inheritance of mitochondria protein 3 ELO PF01151.18 EMD58570.1 - 3.8e-87 292.0 6.9 4.8e-87 291.6 6.9 1.1 1 0 0 1 1 1 1 GNS1/SUR4 family ANAPC10 PF03256.16 EMD58571.1 - 6.3e-44 149.8 0.0 7e-44 149.7 0.0 1.0 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) DUF1230 PF06799.11 EMD58572.1 - 1.3 9.1 4.2 6.5 6.9 0.1 2.6 2 0 0 2 2 2 0 Conserved in the green lineage and diatoms 27 B_solenoid_ydck PF18836.1 EMD58573.1 - 0.046 13.6 0.4 0.17 11.8 0.2 2.0 2 0 0 2 2 2 0 Beta solenoid repeat from YDCK MFS_1 PF07690.16 EMD58574.1 - 8.8e-39 133.4 26.7 1.3e-38 132.9 26.7 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily CN_hydrolase PF00795.22 EMD58576.1 - 3.2e-34 118.5 0.0 7.1e-33 114.0 0.0 2.3 1 1 0 1 1 1 1 Carbon-nitrogen hydrolase Gene66 PF02053.15 EMD58576.1 - 0.095 12.3 0.0 0.15 11.6 0.0 1.3 1 0 0 1 1 1 0 Gene 66 (IR5) protein FBPase PF00316.20 EMD58577.1 - 2.9e-21 75.8 0.0 4.8e-21 75.1 0.0 1.2 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain Inositol_P PF00459.25 EMD58577.1 - 0.076 12.5 1.3 0.081 12.4 0.1 1.6 2 0 0 2 2 2 0 Inositol monophosphatase family Pox_A14 PF05767.12 EMD58578.1 - 2 8.6 6.2 0.21 11.8 0.6 2.2 2 0 0 2 2 2 0 Poxvirus virion envelope protein A14 Peptidase_M24 PF00557.24 EMD58580.1 - 4.3e-58 196.4 0.0 6.1e-58 195.9 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 EMD58580.1 - 5.2e-26 90.8 0.0 1.1e-25 89.7 0.0 1.6 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain F-box PF00646.33 EMD58581.1 - 0.00068 19.5 0.1 0.0029 17.4 0.1 2.1 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EMD58581.1 - 0.0014 18.5 0.2 0.0042 16.9 0.2 1.8 1 0 0 1 1 1 1 F-box-like NOA36 PF06524.12 EMD58581.1 - 0.59 9.4 12.3 0.76 9.0 12.3 1.1 1 0 0 1 1 1 0 NOA36 protein PARP PF00644.20 EMD58582.1 - 2.3e-59 200.3 0.0 4.3e-59 199.4 0.0 1.5 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain PARP_reg PF02877.14 EMD58582.1 - 1e-42 145.5 0.2 1.8e-42 144.7 0.2 1.4 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain WGR PF05406.15 EMD58582.1 - 6e-22 77.5 0.5 1.3e-21 76.5 0.5 1.5 1 0 0 1 1 1 1 WGR domain BRCT PF00533.26 EMD58582.1 - 2.8e-12 46.8 0.0 8.7e-12 45.3 0.0 1.9 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 EMD58582.1 - 2.2e-06 27.5 0.0 5e-06 26.4 0.0 1.6 1 0 0 1 1 1 1 twin BRCT domain BRCT_2 PF16589.5 EMD58582.1 - 0.00016 22.0 0.0 0.00037 20.8 0.0 1.6 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain DUF3335 PF11814.8 EMD58583.1 - 0.075 12.5 0.1 0.12 11.9 0.1 1.2 1 0 0 1 1 1 0 Peptidase_C39 like family Hexapep PF00132.24 EMD58584.1 - 9.1e-07 28.4 0.9 0.0046 16.6 0.3 3.3 1 1 1 2 2 2 2 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.7 EMD58584.1 - 6.7e-05 23.3 0.0 0.00012 22.5 0.0 1.5 1 0 0 1 1 1 1 MobA-like NTP transferase domain DUF4954 PF16314.5 EMD58584.1 - 0.0045 15.2 0.1 0.0069 14.6 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4954) NTP_transferase PF00483.23 EMD58584.1 - 0.0084 15.7 0.0 0.017 14.7 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyl transferase Fucokinase PF07959.12 EMD58584.1 - 0.034 13.1 0.0 0.056 12.4 0.0 1.3 1 0 0 1 1 1 0 L-fucokinase DUF4024 PF13216.6 EMD58585.1 - 0.37 10.8 1.0 16 5.5 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4024) SnoaL PF07366.12 EMD58588.1 - 0.0085 15.9 0.4 2.1 8.1 0.1 2.2 2 0 0 2 2 2 2 SnoaL-like polyketide cyclase RHIM PF12721.7 EMD58589.1 - 0.14 12.7 0.1 0.14 12.7 0.1 5.1 7 0 0 7 7 7 0 RIP homotypic interaction motif Glyco_hydro_88 PF07470.13 EMD58590.1 - 2.6e-55 187.9 0.5 3.1e-55 187.6 0.5 1.1 1 0 0 1 1 1 1 Glycosyl Hydrolase Family 88 EAV_GS PF01309.18 EMD58590.1 - 0.1 12.2 0.2 13 5.4 0.1 2.3 2 0 0 2 2 2 0 Equine arteritis virus small envelope glycoprotein MSP1a PF11670.8 EMD58590.1 - 0.13 11.5 0.9 1.4 8.1 0.0 2.3 2 0 0 2 2 2 0 Major surface protein 1a (MSP1a) EBP PF05241.12 EMD58591.1 - 1.7e-56 190.5 10.9 2e-56 190.2 10.9 1.0 1 0 0 1 1 1 1 Emopamil binding protein Amidase PF01425.21 EMD58592.1 - 1.5e-101 340.7 0.0 1.9e-101 340.3 0.0 1.1 1 0 0 1 1 1 1 Amidase adh_short PF00106.25 EMD58593.1 - 1.8e-34 118.9 0.0 5.4e-34 117.4 0.0 1.6 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD58593.1 - 7.5e-23 81.3 0.0 1.4e-22 80.4 0.0 1.4 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD58593.1 - 1.6e-07 31.4 0.0 2.2e-07 30.9 0.0 1.3 1 0 0 1 1 1 1 KR domain ATP-grasp_5 PF13549.6 EMD58593.1 - 0.064 12.7 0.0 0.095 12.1 0.0 1.3 1 0 0 1 1 1 0 ATP-grasp domain NmrA PF05368.13 EMD58593.1 - 0.082 12.5 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 NmrA-like family Syja_N PF02383.18 EMD58594.1 - 2.9e-91 306.1 0.0 4.2e-91 305.6 0.0 1.2 1 0 0 1 1 1 1 SacI homology domain hSac2 PF12456.8 EMD58594.1 - 1.2e-33 115.2 0.0 2.4e-33 114.3 0.0 1.5 1 0 0 1 1 1 1 Inositol phosphatase DMRT-like PF15791.5 EMD58594.1 - 0.12 12.8 0.8 0.37 11.2 0.8 1.8 1 0 0 1 1 1 0 Doublesex-and mab-3-related transcription factor C1 and C2 Aldolase_II PF00596.21 EMD58596.1 - 4.1e-50 170.3 0.0 5.2e-50 170.0 0.0 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain Peroxidase_2 PF01328.17 EMD58597.1 - 5.1e-41 141.3 0.0 7.2e-41 140.8 0.0 1.2 1 0 0 1 1 1 1 Peroxidase, family 2 DUF2768 PF10966.8 EMD58598.1 - 1.5 9.3 5.2 0.76 10.3 1.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2768) Pyridoxal_deC PF00282.19 EMD58599.1 - 1.3e-74 251.2 0.0 1.6e-74 250.9 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Fungal_trans PF04082.18 EMD58600.1 - 1.1e-16 60.7 0.9 2e-16 59.9 0.9 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD58600.1 - 4.1e-07 30.0 14.2 8.7e-07 29.0 14.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Gemini_AC4_5 PF04807.12 EMD58602.1 - 0.19 11.4 0.4 1.2 8.9 0.0 2.1 2 0 0 2 2 2 0 Geminivirus AC4/5 conserved region adh_short_C2 PF13561.6 EMD58603.1 - 3e-41 141.5 2.6 4e-41 141.1 2.6 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EMD58603.1 - 8.4e-39 133.1 1.0 1.3e-38 132.4 1.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EMD58603.1 - 7.9e-09 35.7 0.4 1.7e-08 34.6 0.4 1.5 1 1 0 1 1 1 1 KR domain DUF1989 PF09347.10 EMD58604.1 - 3.9e-66 221.8 0.0 4.9e-66 221.5 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1989) HMGL-like PF00682.19 EMD58605.1 - 6.7e-79 265.2 0.0 1.2e-78 264.3 0.0 1.4 2 0 0 2 2 2 1 HMGL-like LeuA_dimer PF08502.10 EMD58605.1 - 1.1e-23 83.6 0.1 3.2e-23 82.1 0.1 1.8 1 1 0 1 1 1 1 LeuA allosteric (dimerisation) domain DUF2347 PF09804.9 EMD58606.1 - 2.9e-87 292.8 0.0 6.6e-87 291.7 0.0 1.5 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2347) DUF4484 PF14831.6 EMD58606.1 - 1.3e-34 120.2 17.3 1.4e-16 61.2 0.1 4.0 2 1 2 4 4 4 3 Domain of unknown function (DUF4484) SPA PF08616.10 EMD58606.1 - 0.0011 18.9 0.0 0.0028 17.6 0.0 1.6 1 1 0 1 1 1 1 Stabilization of polarity axis Avl9 PF09794.9 EMD58606.1 - 0.0023 16.7 0.0 1.7 7.2 0.0 2.5 3 0 0 3 3 3 2 Transport protein Avl9 Sugar_tr PF00083.24 EMD58607.1 - 1.1e-110 370.6 15.0 1.3e-110 370.4 15.0 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD58607.1 - 2.6e-28 99.0 27.2 2.5e-27 95.7 16.1 2.2 1 1 0 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EMD58607.1 - 2.5e-05 22.9 0.6 2.5e-05 22.9 0.6 1.7 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) MFS_5 PF05631.14 EMD58607.1 - 0.00023 20.2 0.9 0.00049 19.1 0.9 1.5 1 0 0 1 1 1 1 Sugar-tranasporters, 12 TM MFS_2 PF13347.6 EMD58607.1 - 0.00075 18.2 18.5 0.0021 16.7 0.3 3.0 4 0 0 4 4 4 2 MFS/sugar transport protein LysM PF01476.20 EMD58608.1 - 9.7e-18 64.0 0.1 0.0005 20.1 0.0 5.1 6 0 0 6 6 6 4 LysM domain DUF1153 PF06627.11 EMD58608.1 - 0.022 14.9 0.0 11 6.3 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1153) LRV_FeS PF05484.11 EMD58608.1 - 0.024 14.6 0.0 3.2 7.8 0.0 3.9 4 0 0 4 4 4 0 LRV protein FeS4 cluster HTH_Tnp_1 PF01527.20 EMD58608.1 - 0.2 12.0 0.0 30 5.0 0.0 2.9 3 0 0 3 3 3 0 Transposase Cu-binding_MopE PF11617.8 EMD58608.1 - 0.45 10.7 6.6 18 5.6 0.0 3.8 3 0 0 3 3 3 0 Putative metal-binding motif Reprolysin_5 PF13688.6 EMD58609.1 - 0.00082 19.6 0.3 0.0014 18.8 0.3 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.6 EMD58609.1 - 0.012 16.1 0.3 0.025 15.1 0.3 1.6 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 EMD58609.1 - 0.018 15.0 0.3 0.03 14.2 0.3 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 EMD58609.1 - 0.059 13.0 0.1 0.1 12.2 0.1 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Astacin PF01400.24 EMD58609.1 - 0.078 12.6 1.4 0.15 11.7 0.4 2.0 2 0 0 2 2 2 0 Astacin (Peptidase family M12A) Peptidase_M10 PF00413.24 EMD58609.1 - 0.085 12.7 0.0 0.14 12.0 0.0 1.6 1 0 0 1 1 1 0 Matrixin Peptidase_M78 PF06114.13 EMD58609.1 - 0.16 11.9 0.3 5.6 6.9 0.1 2.3 1 1 0 2 2 2 0 IrrE N-terminal-like domain Glyco_hydro_18 PF00704.28 EMD58610.1 - 1.3e-66 225.5 0.0 1.5e-66 225.3 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Chitin_bind_1 PF00187.19 EMD58610.1 - 1.8e-10 41.1 4.8 1.8e-10 41.1 4.8 2.9 2 1 0 2 2 2 1 Chitin recognition protein Fungal_lectin_2 PF18647.1 EMD58611.1 - 4.5e-37 126.6 1.8 1.1e-36 125.3 1.8 1.7 1 0 0 1 1 1 1 Alpha-galactosyl-binding fungal lectin Lipase_GDSL_2 PF13472.6 EMD58611.1 - 9.2e-12 45.7 0.3 1.1e-09 39.0 0.0 2.8 3 0 0 3 3 3 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EMD58611.1 - 4.6e-07 30.0 0.0 1.2e-06 28.6 0.0 1.7 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Glu_syn_central PF04898.14 EMD58611.1 - 0.047 13.2 0.1 0.076 12.5 0.1 1.2 1 0 0 1 1 1 0 Glutamate synthase central domain Arf PF00025.21 EMD58612.1 - 5.3e-41 140.0 0.0 6.6e-26 90.8 0.0 2.0 2 0 0 2 2 2 2 ADP-ribosylation factor family G-alpha PF00503.20 EMD58612.1 - 4.9e-14 52.3 0.0 2.7e-08 33.4 0.0 2.0 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 EMD58612.1 - 1e-11 44.7 0.0 1.1e-07 31.5 0.0 2.1 2 0 0 2 2 2 2 Ras family Roc PF08477.13 EMD58612.1 - 1.6e-11 44.5 0.0 5.4e-11 42.8 0.0 1.8 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EMD58612.1 - 7.1e-07 28.8 0.0 1.6e-05 24.5 0.0 2.1 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 EMD58612.1 - 7.6e-07 28.7 0.0 9.5e-07 28.4 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EMD58612.1 - 3e-06 27.3 0.0 4.3e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EMD58612.1 - 0.00063 19.3 0.0 0.046 13.3 0.0 2.3 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 EMD58612.1 - 0.034 13.7 0.1 0.071 12.6 0.1 1.7 2 1 0 2 2 2 0 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EMD58612.1 - 0.16 11.9 0.1 12 5.7 0.1 2.4 3 0 0 3 3 3 0 RsgA GTPase Sugar_tr PF00083.24 EMD58615.1 - 7.1e-19 68.0 8.5 7.8e-19 67.9 8.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter Glyco_hydro_cc PF11790.8 EMD58617.1 - 9.4e-68 228.3 0.0 1.1e-67 228.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core Ribosomal_L22 PF00237.19 EMD58618.1 - 1.5e-40 137.6 1.1 5.6e-40 135.7 0.1 1.9 2 0 0 2 2 2 1 Ribosomal protein L22p/L17e Fibrillarin PF01269.17 EMD58619.1 - 6.7e-104 345.9 0.0 8.2e-104 345.7 0.0 1.0 1 0 0 1 1 1 1 Fibrillarin GCD14 PF08704.10 EMD58619.1 - 7.1e-05 22.6 0.0 0.0001 22.1 0.0 1.1 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Methyltr_RsmB-F PF01189.17 EMD58619.1 - 0.0097 15.6 0.0 0.015 14.9 0.0 1.2 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F PCMT PF01135.19 EMD58619.1 - 0.062 13.1 0.0 0.1 12.3 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) adh_short_C2 PF13561.6 EMD58620.1 - 4.4e-36 124.6 0.0 1.8e-34 119.3 0.0 2.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EMD58620.1 - 2.2e-33 115.4 0.0 7.3e-33 113.7 0.0 1.9 1 1 0 1 1 1 1 short chain dehydrogenase Lactamase_B_4 PF13691.6 EMD58620.1 - 3e-23 81.3 1.3 1.3e-22 79.2 0.1 2.6 3 0 0 3 3 3 1 tRNase Z endonuclease Lactamase_B_2 PF12706.7 EMD58620.1 - 7.5e-08 32.1 0.3 7.9e-05 22.3 0.1 2.7 2 0 0 2 2 2 2 Beta-lactamase superfamily domain Lactamase_B PF00753.27 EMD58620.1 - 0.0054 16.8 0.1 0.013 15.5 0.1 1.7 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily DUF1776 PF08643.10 EMD58620.1 - 0.19 11.1 0.0 0.54 9.6 0.0 1.7 2 0 0 2 2 2 0 Fungal family of unknown function (DUF1776) Fungal_trans_2 PF11951.8 EMD58621.1 - 3e-06 26.3 0.1 8.4e-06 24.8 0.1 1.7 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD58621.1 - 8.3e-06 25.8 9.2 1.7e-05 24.8 9.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF2306 PF10067.9 EMD58622.1 - 1.5e-12 47.9 7.3 3.2e-12 46.9 7.3 1.5 1 0 0 1 1 1 1 Predicted membrane protein (DUF2306) BTB_2 PF02214.22 EMD58623.1 - 2.6e-05 24.5 0.0 0.0085 16.4 0.0 2.5 2 0 0 2 2 2 2 BTB/POZ domain GST_N PF02798.20 EMD58624.1 - 3.8e-14 52.8 0.0 7.6e-14 51.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EMD58624.1 - 2.5e-08 34.1 0.0 4.6e-08 33.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EMD58624.1 - 5.3e-08 33.0 0.0 9.7e-08 32.1 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EMD58624.1 - 4.4e-07 30.2 0.0 8.8e-07 29.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EMD58624.1 - 4.5e-06 26.8 0.0 8e-06 26.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EMD58624.1 - 0.00012 22.1 0.0 0.00022 21.2 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_5 PF16865.5 EMD58624.1 - 0.025 15.2 0.0 0.041 14.5 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain NDUF_B4 PF07225.12 EMD58625.1 - 0.00031 20.6 0.1 0.00036 20.4 0.1 1.1 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4) DUF2839 PF10999.8 EMD58625.1 - 0.0047 17.3 0.2 0.0077 16.6 0.2 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2839) Cupin_1 PF00190.22 EMD58626.1 - 7.9e-22 77.5 0.2 1.2e-21 76.9 0.2 1.3 1 0 0 1 1 1 1 Cupin Cupin_2 PF07883.11 EMD58626.1 - 0.00063 19.4 0.0 0.11 12.3 0.0 2.4 2 0 0 2 2 2 2 Cupin domain OGFr_N PF04664.13 EMD58627.1 - 1.4e-20 73.7 0.0 6.3e-12 45.5 0.0 2.2 2 0 0 2 2 2 2 Opioid growth factor receptor (OGFr) conserved region CAML PF14963.6 EMD58627.1 - 2.2 8.3 4.5 14 5.7 0.0 2.1 2 0 0 2 2 2 0 Calcium signal-modulating cyclophilin ligand Alpha-amylase PF00128.24 EMD58628.1 - 5.9e-25 88.5 1.4 1.1e-24 87.7 1.4 1.4 1 1 0 1 1 1 1 Alpha amylase, catalytic domain DUF1939 PF09154.10 EMD58628.1 - 0.0042 17.2 0.3 0.057 13.6 0.0 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF1939) MFS_1 PF07690.16 EMD58629.1 - 3.4e-15 55.8 14.2 4e-15 55.6 12.8 1.9 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EMD58629.1 - 9.1e-08 31.4 2.0 9.1e-08 31.4 2.0 3.3 2 1 1 3 3 3 2 Sugar (and other) transporter DUF724 PF05266.14 EMD58630.1 - 0.01 15.7 6.4 0.01 15.7 6.4 3.5 2 1 1 3 3 3 0 Protein of unknown function (DUF724) LPP PF04728.13 EMD58630.1 - 0.013 15.9 0.8 0.47 10.9 0.1 3.2 2 0 0 2 2 2 0 Lipoprotein leucine-zipper Bacillus_HBL PF05791.11 EMD58630.1 - 0.98 9.2 10.2 1.8 8.3 10.0 1.6 1 1 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) GIT_CC PF16559.5 EMD58630.1 - 1.1 9.1 5.2 5.9 6.8 0.9 2.8 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor Tropomyosin_1 PF12718.7 EMD58630.1 - 2.2 8.4 36.2 0.059 13.5 3.2 3.7 1 1 2 3 3 3 0 Tropomyosin like ALMT PF11744.8 EMD58630.1 - 5.6 5.7 25.2 0.18 10.6 14.4 2.1 1 1 1 2 2 2 0 Aluminium activated malate transporter Ribosomal_S7 PF00177.21 EMD58631.1 - 1.6e-36 125.2 1.2 1.9e-36 124.9 1.2 1.1 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e AAA_11 PF13086.6 EMD58632.1 - 3.9 7.2 7.6 6.2 6.5 7.6 1.2 1 0 0 1 1 1 0 AAA domain Presenilin PF01080.17 EMD58632.1 - 5.4 5.7 5.2 1.3 7.7 1.8 1.6 2 0 0 2 2 2 0 Presenilin RPE65 PF03055.15 EMD58633.1 - 4.2e-107 359.2 0.0 5e-107 359.0 0.0 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein hNIFK_binding PF12196.8 EMD58634.1 - 0.13 11.7 0.4 0.22 11.0 0.4 1.4 1 0 0 1 1 1 0 FHA Ki67 binding domain of hNIFK ATP-synt_Eps PF04627.13 EMD58635.1 - 0.15 12.1 0.0 0.24 11.4 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial ATP synthase epsilon chain Tmemb_cc2 PF10267.9 EMD58636.1 - 0.07 12.3 2.6 0.087 12.0 2.6 1.1 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein DUF4179 PF13786.6 EMD58636.1 - 0.15 12.6 1.5 0.46 11.0 1.5 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4179) DUF4366 PF14283.6 EMD58636.1 - 1.3 9.0 6.4 1.2 9.1 0.6 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4366) Hamartin PF04388.12 EMD58636.1 - 8.6 4.9 6.8 9.9 4.7 6.8 1.1 1 0 0 1 1 1 0 Hamartin protein zf-RING_2 PF13639.6 EMD58638.1 - 4e-12 46.3 6.0 4e-12 46.3 6.0 1.8 2 0 0 2 2 1 1 Ring finger domain zf-RING_UBOX PF13445.6 EMD58638.1 - 3.7e-08 33.2 5.6 8.8e-08 32.0 5.6 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-rbx1 PF12678.7 EMD58638.1 - 1.7e-07 31.4 6.4 3.9e-07 30.3 6.4 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 EMD58638.1 - 2.4e-07 30.5 6.5 4.3e-07 29.7 6.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EMD58638.1 - 2.4e-07 30.6 6.8 4.5e-07 29.7 6.8 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EMD58638.1 - 9.5e-06 25.4 4.0 2e-05 24.4 4.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EMD58638.1 - 2.2e-05 24.2 6.1 4e-05 23.4 6.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EMD58638.1 - 3.7e-05 23.8 4.7 7.2e-05 22.9 4.7 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 EMD58638.1 - 9.1e-05 22.2 6.5 0.00017 21.3 6.5 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_11 PF17123.5 EMD58638.1 - 0.00052 19.7 5.6 0.00052 19.7 5.6 1.9 2 0 0 2 2 2 1 RING-like zinc finger zf-ANAPC11 PF12861.7 EMD58638.1 - 0.0008 19.4 4.0 0.002 18.2 4.0 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_6 PF14835.6 EMD58638.1 - 0.027 14.3 1.5 0.027 14.3 1.5 2.0 2 0 0 2 2 2 0 zf-RING of BARD1-type protein Zn_ribbon_17 PF17120.5 EMD58638.1 - 0.028 14.0 5.9 0.076 12.6 4.5 2.2 1 1 1 2 2 2 0 Zinc-ribbon, C4HC2 type RINGv PF12906.7 EMD58638.1 - 0.056 13.6 4.0 0.074 13.2 2.2 2.2 2 1 0 2 2 2 0 RING-variant domain DUF1205 PF06722.12 EMD58638.1 - 0.12 12.5 0.0 0.34 11.1 0.0 1.7 2 0 0 2 2 1 0 Protein of unknown function (DUF1205) zf-RING_4 PF14570.6 EMD58638.1 - 0.2 11.5 2.9 0.47 10.3 2.9 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-Nse PF11789.8 EMD58638.1 - 0.34 10.8 3.9 0.63 9.9 3.9 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Isochorismatase PF00857.20 EMD58639.1 - 4.3e-40 137.7 0.1 4.8e-40 137.6 0.1 1.0 1 0 0 1 1 1 1 Isochorismatase family L_biotic_typeA PF04604.13 EMD58641.1 - 0.044 13.6 0.0 0.08 12.8 0.0 1.4 1 0 0 1 1 1 0 Type-A lantibiotic Glyco_hydro_11 PF00457.17 EMD58642.1 - 2.1e-77 258.7 22.6 2.6e-77 258.5 22.6 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 11 ALO PF04030.14 EMD58643.1 - 9.3e-86 287.8 1.5 1.4e-85 287.3 1.5 1.2 1 0 0 1 1 1 1 D-arabinono-1,4-lactone oxidase FAD_binding_4 PF01565.23 EMD58643.1 - 1.2e-31 109.3 0.1 1.8e-31 108.7 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain NRDE-2 PF08424.10 EMD58645.1 - 9.3e-88 294.4 1.0 8.1e-86 288.1 0.0 2.7 3 0 0 3 3 3 2 NRDE-2, necessary for RNA interference Cwf_Cwc_15 PF04889.12 EMD58645.1 - 0.0018 18.0 8.1 0.0018 18.0 8.1 2.7 3 0 0 3 3 3 1 Cwf15/Cwc15 cell cycle control protein TPR_14 PF13428.6 EMD58645.1 - 0.045 14.6 7.6 50 5.1 0.0 6.2 6 1 0 6 6 6 0 Tetratricopeptide repeat TPR_12 PF13424.6 EMD58645.1 - 0.13 12.5 1.6 0.27 11.6 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat NOA36 PF06524.12 EMD58645.1 - 0.35 10.2 3.4 0.7 9.2 3.4 1.4 1 0 0 1 1 1 0 NOA36 protein CENP-B_dimeris PF09026.10 EMD58645.1 - 8.3 6.9 11.8 24 5.4 10.7 2.2 2 0 0 2 2 2 0 Centromere protein B dimerisation domain BP28CT PF08146.12 EMD58646.1 - 4.6e-37 127.3 3.8 8.9e-37 126.4 2.1 2.5 2 0 0 2 2 2 1 BP28CT (NUC211) domain U3snoRNP10 PF12397.8 EMD58646.1 - 8e-21 74.6 1.3 8e-21 74.6 1.3 6.3 7 0 0 7 7 7 1 U3 small nucleolar RNA-associated protein 10 HEAT PF02985.22 EMD58646.1 - 0.0076 16.4 18.6 0.041 14.2 0.1 8.5 9 0 0 9 9 9 1 HEAT repeat ERAP1_C PF11838.8 EMD58646.1 - 0.033 13.7 4.1 0.12 11.9 1.5 3.3 3 1 0 3 3 3 0 ERAP1-like C-terminal domain DnaJ-X PF14308.6 EMD58646.1 - 0.054 12.9 0.9 0.17 11.3 0.9 1.9 1 0 0 1 1 1 0 X-domain of DnaJ-containing HEAT_EZ PF13513.6 EMD58646.1 - 0.098 13.2 11.5 1 10.0 0.7 6.6 6 1 0 6 6 6 0 HEAT-like repeat DUF3361 PF11841.8 EMD58646.1 - 0.25 11.2 5.6 0.5 10.3 0.6 3.8 3 0 0 3 3 3 0 Domain of unknown function (DUF3361) Cnd1 PF12717.7 EMD58646.1 - 0.45 10.6 0.0 0.45 10.6 0.0 4.9 6 0 0 6 6 6 0 non-SMC mitotic condensation complex subunit 1 Fungal_trans PF04082.18 EMD58647.1 - 1.2e-28 99.9 0.0 1.3e-26 93.3 0.0 2.4 2 0 0 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD58647.1 - 2.2e-07 30.9 9.0 3.7e-07 30.2 9.0 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ATP12 PF07542.11 EMD58648.1 - 7.4e-42 142.5 0.4 1.4e-41 141.6 0.4 1.5 1 0 0 1 1 1 1 ATP12 chaperone protein Oxysterol_BP PF01237.18 EMD58649.1 - 3.5e-136 453.9 0.0 3.5e-136 453.9 0.0 2.5 3 0 0 3 3 3 1 Oxysterol-binding protein Ank_5 PF13857.6 EMD58649.1 - 2.8e-18 65.7 0.2 1.5e-10 41.1 0.1 3.6 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 EMD58649.1 - 4.3e-13 49.7 0.0 3.4e-08 33.9 0.0 3.4 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) PH PF00169.29 EMD58649.1 - 1.4e-12 48.1 0.7 3e-12 47.0 0.7 1.6 1 0 0 1 1 1 1 PH domain Ank_4 PF13637.6 EMD58649.1 - 4.3e-12 46.3 0.0 4.7e-05 23.9 0.0 3.7 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMD58649.1 - 2.3e-11 42.8 0.3 6.6e-05 23.0 0.0 4.3 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.30 EMD58649.1 - 4.7e-11 42.6 0.2 0.00036 20.8 0.1 4.6 4 0 0 4 4 4 2 Ankyrin repeat PH_8 PF15409.6 EMD58649.1 - 2.7e-07 30.8 1.1 8.8e-07 29.1 1.1 1.9 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 EMD58649.1 - 1.8e-05 25.1 3.9 3.8e-05 24.0 2.5 2.4 2 1 0 2 2 2 1 Pleckstrin homology domain DUF3246 PF11596.8 EMD58649.1 - 1.8 8.0 8.7 1.5 8.2 3.9 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3246) Amidase PF01425.21 EMD58650.1 - 2e-68 231.4 0.2 9.7e-63 212.7 0.0 2.4 2 1 0 2 2 2 2 Amidase SRP1_TIP1 PF00660.17 EMD58650.1 - 0.11 12.6 0.3 4.8 7.3 0.0 2.5 2 0 0 2 2 2 0 Seripauperin and TIP1 family CAP59_mtransfer PF11735.8 EMD58651.1 - 1.1e-88 297.1 0.0 1.6e-88 296.5 0.0 1.3 1 0 0 1 1 1 1 Cryptococcal mannosyltransferase 1 Glyco_transf_8 PF01501.20 EMD58651.1 - 0.034 13.7 0.0 0.055 13.0 0.0 1.3 1 0 0 1 1 1 0 Glycosyl transferase family 8 SANTA PF09133.10 EMD58652.1 - 0.0073 16.8 0.1 1.3 9.6 0.0 2.4 2 0 0 2 2 2 2 SANTA (SANT Associated) Glyco_transf_90 PF05686.12 EMD58653.1 - 1.4e-12 47.2 1.0 3e-10 39.6 0.7 2.6 2 1 0 2 2 2 2 Glycosyl transferase family 90 HemY_N PF07219.13 EMD58656.1 - 0.62 10.3 4.9 0.67 10.2 4.9 1.1 1 0 0 1 1 1 0 HemY protein N-terminus DUF5081 PF16887.5 EMD58657.1 - 0.049 12.7 5.8 0.079 12.0 5.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5081) TOPRIM_C PF16898.5 EMD58657.1 - 0.57 10.5 4.3 0.76 10.1 2.0 2.0 1 1 1 2 2 2 0 C-terminal associated domain of TOPRIM Guanylate_cyc_2 PF09778.9 EMD58657.1 - 2.6 7.4 5.3 3.1 7.1 0.6 2.3 1 1 2 3 3 3 0 Guanylylate cyclase TMF_DNA_bd PF12329.8 EMD58657.1 - 5.4 7.1 12.4 3.5 7.7 0.5 2.6 2 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding ABC_tran_CTD PF16326.5 EMD58657.1 - 6 7.2 17.8 11 6.3 1.2 2.9 2 1 0 2 2 2 0 ABC transporter C-terminal domain SlyX PF04102.12 EMD58657.1 - 8.2 7.1 9.8 2.2 9.0 1.4 2.8 2 1 0 2 2 2 0 SlyX EF-hand_1 PF00036.32 EMD58658.1 - 5.2e-27 91.3 12.1 3.7e-07 29.2 0.6 4.3 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 EMD58658.1 - 8e-24 83.9 13.8 3.1e-14 53.2 1.6 2.8 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 EMD58658.1 - 1.7e-20 71.1 6.0 6.9e-05 22.5 0.0 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 EMD58658.1 - 1.7e-18 65.2 10.2 1.5e-06 27.4 0.3 4.4 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 EMD58658.1 - 1.2e-13 50.6 11.5 9.9e-05 22.1 0.6 4.1 2 1 2 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EMD58658.1 - 2.5e-06 27.8 0.0 0.0048 17.2 0.0 2.3 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 EMD58658.1 - 6.7e-06 26.0 6.8 0.0033 17.4 0.4 3.7 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand Dockerin_1 PF00404.18 EMD58658.1 - 0.033 14.4 0.7 0.13 12.5 0.6 2.1 1 1 0 1 1 1 0 Dockerin type I domain Anillin PF08174.11 EMD58658.1 - 0.07 13.6 0.0 2.3 8.6 0.0 2.1 1 1 0 2 2 2 0 Cell division protein anillin EF-hand_9 PF14658.6 EMD58658.1 - 0.094 13.1 0.1 4.3 7.7 0.1 2.9 2 1 1 3 3 3 0 EF-hand domain PMBR PF09373.10 EMD58658.1 - 0.16 12.2 0.0 4.9 7.5 0.0 2.4 2 0 0 2 2 2 0 Pseudomurein-binding repeat DUF1770 PF08589.10 EMD58659.1 - 1.6e-32 112.4 0.0 2.2e-32 112.0 0.0 1.2 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1770) SNF2_N PF00176.23 EMD58660.1 - 9.1e-60 202.2 0.0 1.4e-59 201.6 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EMD58660.1 - 3.9e-15 56.2 0.0 7.9e-15 55.2 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EMD58660.1 - 9.6e-09 35.5 0.0 1.6e-08 34.7 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 EMD58660.1 - 2.6e-05 23.5 0.0 5.1e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 SWI2_SNF2 PF18766.1 EMD58660.1 - 0.1 12.2 0.0 0.19 11.4 0.0 1.5 1 0 0 1 1 1 0 SWI2/SNF2 ATPase DUF2439 PF10382.9 EMD58660.1 - 0.13 12.6 0.3 0.34 11.3 0.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2439) RNR_inhib PF08591.10 EMD58662.1 - 7.4e-22 78.7 0.0 1.9e-21 77.4 0.0 1.7 1 1 0 1 1 1 1 Ribonucleotide reductase inhibitor Peptidase_A24 PF01478.18 EMD58663.1 - 0.00039 20.8 0.0 0.0017 18.8 0.0 1.9 1 1 0 1 1 1 1 Type IV leader peptidase family MARVEL PF01284.23 EMD58663.1 - 0.0055 16.7 3.3 0.01 15.8 3.3 1.5 1 1 0 1 1 1 1 Membrane-associating domain PMP1_2 PF08114.11 EMD58663.1 - 0.031 14.0 0.3 0.098 12.4 0.3 1.8 1 0 0 1 1 1 0 ATPase proteolipid family DUF2976 PF11190.8 EMD58663.1 - 0.21 11.4 3.4 0.78 9.6 0.3 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF2976) BPD_transp_1 PF00528.22 EMD58663.1 - 0.57 9.9 11.0 4.5 7.0 5.8 2.8 1 1 2 3 3 3 0 Binding-protein-dependent transport system inner membrane component UBA_4 PF14555.6 EMD58664.1 - 0.00088 19.0 0.0 0.0017 18.1 0.0 1.4 1 0 0 1 1 1 1 UBA-like domain LysM PF01476.20 EMD58664.1 - 0.0012 18.8 0.0 0.0022 18.0 0.0 1.4 1 0 0 1 1 1 1 LysM domain TAP_C PF03943.13 EMD58664.1 - 0.02 14.5 0.7 0.038 13.6 0.1 1.7 2 0 0 2 2 2 0 TAP C-terminal domain Prok-RING_4 PF14447.6 EMD58664.1 - 0.077 12.9 8.3 0.14 12.0 8.3 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 Baculo_IE-1 PF05290.11 EMD58664.1 - 0.14 12.2 1.4 0.24 11.3 1.4 1.3 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) Ribosomal_S8 PF00410.19 EMD58665.1 - 7.2e-22 77.7 0.2 1.2e-21 77.0 0.2 1.3 1 1 0 1 1 1 1 Ribosomal protein S8 AAA_2 PF07724.14 EMD58666.1 - 4.2e-47 160.4 0.0 2.3e-45 154.8 0.0 3.1 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 EMD58666.1 - 1.4e-34 118.1 1.9 1.4e-34 118.1 1.9 3.9 4 1 1 5 5 5 1 AAA lid domain AAA PF00004.29 EMD58666.1 - 1.2e-26 93.7 0.0 3.9e-14 53.2 0.0 3.0 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.9 EMD58666.1 - 7.7e-24 83.6 0.3 2.9e-23 81.7 0.3 2.1 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.14 EMD58666.1 - 4.4e-15 55.9 0.5 2.9e-09 37.0 0.0 3.5 3 1 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EMD58666.1 - 1.8e-12 47.7 0.1 0.00011 22.5 0.0 4.6 2 1 1 3 3 3 2 AAA domain AAA_16 PF13191.6 EMD58666.1 - 4.1e-12 46.8 4.1 1.3e-05 25.7 0.1 5.0 4 1 1 5 5 5 2 AAA ATPase domain Clp_N PF02861.20 EMD58666.1 - 1.5e-09 37.8 0.3 0.00049 20.2 0.0 4.1 3 0 0 3 3 3 2 Clp amino terminal domain, pathogenicity island component Sigma54_activat PF00158.26 EMD58666.1 - 1.5e-08 34.5 0.0 2.9e-05 23.9 0.0 2.6 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_18 PF13238.6 EMD58666.1 - 8.3e-07 29.6 3.2 0.11 13.1 0.0 4.9 4 1 0 4 4 3 2 AAA domain AAA_14 PF13173.6 EMD58666.1 - 2.7e-06 27.5 0.0 0.16 12.0 0.0 2.9 2 0 0 2 2 2 2 AAA domain AAA_7 PF12775.7 EMD58666.1 - 3.5e-06 26.7 0.0 0.015 14.9 0.0 2.6 2 0 0 2 2 2 2 P-loop containing dynein motor region IstB_IS21 PF01695.17 EMD58666.1 - 4.4e-06 26.5 0.0 0.082 12.6 0.0 3.1 3 0 0 3 3 3 2 IstB-like ATP binding protein AAA_33 PF13671.6 EMD58666.1 - 1.2e-05 25.5 0.1 0.27 11.4 0.0 3.4 3 0 0 3 3 2 2 AAA domain Mg_chelatase PF01078.21 EMD58666.1 - 1.7e-05 24.3 0.0 0.17 11.2 0.0 3.5 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_30 PF13604.6 EMD58666.1 - 3.7e-05 23.5 0.0 0.43 10.3 0.0 3.6 3 0 0 3 3 3 2 AAA domain RNA_helicase PF00910.22 EMD58666.1 - 6.8e-05 23.2 0.0 0.55 10.6 0.0 2.6 2 0 0 2 2 2 2 RNA helicase ATPase_2 PF01637.18 EMD58666.1 - 8.3e-05 22.6 0.0 5.7 6.8 0.1 4.2 3 1 0 3 3 3 0 ATPase domain predominantly from Archaea AAA_28 PF13521.6 EMD58666.1 - 8.8e-05 22.8 1.9 0.74 10.0 0.0 3.7 4 0 0 4 4 3 2 AAA domain RsgA_GTPase PF03193.16 EMD58666.1 - 0.00015 21.7 0.1 0.53 10.2 0.0 2.9 3 0 0 3 3 2 2 RsgA GTPase AAA_3 PF07726.11 EMD58666.1 - 0.00017 21.5 0.0 0.76 9.6 0.0 3.3 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) TsaE PF02367.17 EMD58666.1 - 0.00019 21.4 0.0 0.22 11.6 0.0 2.5 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE RuvB_N PF05496.12 EMD58666.1 - 0.00036 20.3 1.6 4.3 7.1 0.9 4.4 3 1 0 3 3 3 1 Holliday junction DNA helicase RuvB P-loop domain AAA_24 PF13479.6 EMD58666.1 - 0.00062 19.5 0.0 0.59 9.8 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.6 EMD58666.1 - 0.00084 19.7 2.5 0.33 11.3 0.1 4.1 5 1 0 6 6 3 1 AAA domain Torsin PF06309.11 EMD58666.1 - 0.00097 19.2 0.0 0.011 15.9 0.0 2.4 3 0 0 3 3 2 1 Torsin ABC_tran PF00005.27 EMD58666.1 - 0.00097 19.7 1.6 0.91 10.0 0.0 3.5 4 0 0 4 4 3 1 ABC transporter AAA_29 PF13555.6 EMD58666.1 - 0.0019 17.9 0.0 2 8.2 0.0 2.7 2 0 0 2 2 2 1 P-loop containing region of AAA domain T2SSE PF00437.20 EMD58666.1 - 0.0053 15.9 0.0 0.053 12.6 0.0 2.5 2 0 0 2 2 2 1 Type II/IV secretion system protein NACHT PF05729.12 EMD58666.1 - 0.0073 16.2 0.0 0.57 10.1 0.0 2.7 2 0 0 2 2 2 1 NACHT domain Roc PF08477.13 EMD58666.1 - 0.0093 16.2 0.0 3 8.1 0.0 2.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase DUF1192 PF06698.11 EMD58666.1 - 0.0093 16.0 0.2 0.0093 16.0 0.2 3.0 2 0 0 2 2 1 1 Protein of unknown function (DUF1192) NTPase_1 PF03266.15 EMD58666.1 - 0.013 15.4 0.0 0.27 11.1 0.0 2.7 2 0 0 2 2 2 0 NTPase SRP54 PF00448.22 EMD58666.1 - 0.013 15.1 0.0 2.5 7.7 0.0 2.7 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain Zeta_toxin PF06414.12 EMD58666.1 - 0.014 14.7 0.0 1.3 8.2 0.0 2.7 2 0 0 2 2 2 0 Zeta toxin AAA_25 PF13481.6 EMD58666.1 - 0.018 14.6 1.7 1.4 8.5 0.0 3.2 3 0 0 3 3 2 0 AAA domain Rad17 PF03215.15 EMD58666.1 - 0.019 14.9 0.1 6.3 6.7 0.0 2.7 3 0 0 3 3 2 0 Rad17 P-loop domain ResIII PF04851.15 EMD58666.1 - 0.02 14.9 0.0 1.3 9.0 0.0 3.4 4 0 0 4 4 3 0 Type III restriction enzyme, res subunit CbiA PF01656.23 EMD58666.1 - 0.094 12.8 0.0 27 4.8 0.0 3.1 3 1 0 3 3 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain Spc7 PF08317.11 EMD58666.1 - 0.24 10.3 13.2 0.55 9.1 13.2 1.6 1 0 0 1 1 1 0 Spc7 kinetochore protein AAA_23 PF13476.6 EMD58666.1 - 0.37 11.3 0.0 0.37 11.3 0.0 4.9 4 2 0 5 5 3 0 AAA domain Sec63 PF02889.16 EMD58668.1 - 9.8e-17 61.0 0.0 1e-15 57.6 0.0 2.4 2 1 0 2 2 2 1 Sec63 Brl domain DnaJ PF00226.31 EMD58668.1 - 1.5e-14 53.9 0.2 4.1e-14 52.4 0.2 1.8 1 0 0 1 1 1 1 DnaJ domain Pkinase PF00069.25 EMD58669.1 - 2.3e-51 174.7 0.0 1.5e-48 165.5 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EMD58669.1 - 2.1e-30 105.9 0.0 3.5e-29 101.9 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase Seadorna_VP7 PF07387.11 EMD58669.1 - 0.0032 16.6 0.1 0.0049 16.0 0.1 1.2 1 0 0 1 1 1 1 Seadornavirus VP7 Kinase-like PF14531.6 EMD58669.1 - 0.0056 16.0 0.0 0.0084 15.5 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EMD58669.1 - 0.06 12.3 0.0 0.091 11.7 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Pkinase_fungal PF17667.1 EMD58669.1 - 0.2 10.4 0.0 0.31 9.8 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Choline_kinase PF01633.20 EMD58670.1 - 9.2e-64 214.9 0.1 5.8e-63 212.3 0.0 2.2 2 0 0 2 2 2 1 Choline/ethanolamine kinase Mem_trans PF03547.18 EMD58670.1 - 1.4e-44 152.0 6.9 5.1e-44 150.2 6.9 1.8 1 1 0 1 1 1 1 Membrane transport protein Choline_kin_N PF04428.14 EMD58670.1 - 3.8e-16 58.5 0.1 8.1e-16 57.4 0.1 1.6 1 0 0 1 1 1 1 Choline kinase N terminus APH PF01636.23 EMD58670.1 - 0.0029 17.5 1.6 0.0036 17.2 0.0 2.0 2 0 0 2 2 2 1 Phosphotransferase enzyme family Mis12 PF05859.12 EMD58671.1 - 1.3e-40 138.6 0.0 1.9e-40 138.0 0.0 1.3 1 0 0 1 1 1 1 Mis12 protein Pkinase PF00069.25 EMD58672.1 - 3.4e-51 174.1 0.0 2.9e-50 171.1 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD58672.1 - 7.9e-20 71.2 0.0 1.4e-18 67.2 0.0 2.6 2 1 0 2 2 2 1 Protein tyrosine kinase DUF4148 PF13663.6 EMD58672.1 - 0.12 12.6 1.6 0.13 12.5 0.2 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4148) Aminotran_3 PF00202.21 EMD58673.1 - 5.4e-77 259.2 0.0 6.5e-77 258.9 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III SRP19 PF01922.17 EMD58674.1 - 1.2e-34 119.1 0.0 2e-34 118.4 0.0 1.3 1 0 0 1 1 1 1 SRP19 protein Asp PF00026.23 EMD58675.1 - 1.5e-68 231.6 10.2 1.7e-68 231.3 10.2 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EMD58675.1 - 1.5e-08 35.0 3.1 6e-05 23.4 2.4 3.2 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EMD58675.1 - 2.4e-06 28.1 0.2 0.001 19.7 0.0 2.8 2 1 0 2 2 2 2 Aspartyl protease gag-asp_proteas PF13975.6 EMD58675.1 - 0.0011 19.5 0.1 0.054 14.1 0.0 2.8 2 1 0 2 2 2 1 gag-polyprotein putative aspartyl protease Toxin_10 PF05431.11 EMD58675.1 - 0.045 13.2 0.3 0.1 12.1 0.3 1.5 1 0 0 1 1 1 0 Insecticidal Crystal Toxin, P42 DEAD PF00270.29 EMD58676.1 - 1.7e-33 115.9 0.3 1.1e-15 57.9 0.2 2.7 2 1 1 3 3 3 2 DEAD/DEAH box helicase Helicase_C PF00271.31 EMD58676.1 - 2.3e-24 85.9 0.0 6.6e-24 84.4 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EMD58676.1 - 1.4e-05 25.2 1.7 1.8e-05 24.8 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Hamartin PF04388.12 EMD58676.1 - 9.5 4.7 13.5 1.1 7.9 8.9 1.7 2 0 0 2 2 2 0 Hamartin protein PIGA PF08288.12 EMD58677.1 - 9.5e-48 160.7 2.3 1.1e-47 160.6 0.9 1.9 2 0 0 2 2 2 1 PIGA (GPI anchor biosynthesis) Glyco_transf_4 PF13439.6 EMD58677.1 - 1.2e-28 100.2 1.1 2.3e-28 99.3 0.7 1.7 2 0 0 2 2 2 1 Glycosyltransferase Family 4 Glycos_transf_1 PF00534.20 EMD58677.1 - 3.7e-25 88.4 0.0 6.1e-25 87.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EMD58677.1 - 5.2e-24 85.2 0.4 1.2e-23 84.1 0.4 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 EMD58677.1 - 3.4e-13 50.4 0.0 8.5e-13 49.0 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_1_2 PF13524.6 EMD58677.1 - 2.4e-05 24.6 0.0 0.00015 22.1 0.0 2.1 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_4_2 PF13477.6 EMD58677.1 - 8.7e-05 22.6 0.1 0.00017 21.6 0.1 1.4 1 0 0 1 1 1 1 Glycosyl transferase 4-like Glyco_transf_5 PF08323.11 EMD58677.1 - 0.012 15.4 0.0 0.025 14.3 0.0 1.7 1 1 0 1 1 1 0 Starch synthase catalytic domain EutK_C PF16365.5 EMD58677.1 - 0.14 12.2 0.3 0.31 11.1 0.3 1.5 1 0 0 1 1 1 0 Ethanolamine utilization protein EutK C-terminus DUF3455 PF11937.8 EMD58678.1 - 1.9e-41 142.1 0.8 2.5e-41 141.7 0.8 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3455) DUF2990 PF11693.8 EMD58678.1 - 0.098 12.8 1.0 0.69 10.1 1.0 2.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2990) CASP_C PF08172.12 EMD58679.1 - 4.9e-91 304.6 0.0 4.9e-91 304.6 0.0 3.8 2 1 1 3 3 3 1 CASP C terminal CtIP_N PF10482.9 EMD58679.1 - 0.0056 16.7 0.2 0.0056 16.7 0.2 5.4 5 1 1 6 6 6 2 Tumour-suppressor protein CtIP N-terminal domain ZapB PF06005.12 EMD58679.1 - 0.16 12.4 0.0 0.16 12.4 0.0 6.4 4 3 1 5 5 5 0 Cell division protein ZapB Fez1 PF06818.15 EMD58679.1 - 3.2 8.2 50.3 3.9 7.9 16.3 4.4 4 1 1 5 5 5 0 Fez1 Aida_N PF08910.10 EMD58679.1 - 8 6.9 10.8 16 6.0 1.5 3.6 2 1 1 3 3 3 0 Aida N-terminus Vps39_2 PF10367.9 EMD58680.1 - 1.3e-08 35.2 0.0 1.2e-07 32.2 0.0 2.3 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 2 Clathrin PF00637.20 EMD58680.1 - 2.3e-08 34.0 0.1 6.9e-07 29.2 0.1 2.6 1 1 0 1 1 1 1 Region in Clathrin and VPS Vps39_1 PF10366.9 EMD58680.1 - 0.0092 16.2 0.3 2.7 8.3 0.0 3.1 3 0 0 3 3 3 1 Vacuolar sorting protein 39 domain 1 Reg_prop PF07494.11 EMD58680.1 - 0.15 12.3 0.3 2.3 8.7 0.0 2.7 2 0 0 2 2 2 0 Two component regulator propeller Prefoldin_2 PF01920.20 EMD58681.1 - 9.8e-23 80.1 3.6 1.3e-22 79.7 3.6 1.2 1 0 0 1 1 1 1 Prefoldin subunit DUF2353 PF09789.9 EMD58681.1 - 0.043 13.2 8.7 3.3 7.0 6.9 2.0 2 0 0 2 2 2 0 Uncharacterized coiled-coil protein (DUF2353) YojJ PF10372.9 EMD58681.1 - 0.15 12.2 3.0 5.3 7.2 1.1 2.3 2 0 0 2 2 2 0 Bacterial membrane-spanning protein N-terminus FlaC_arch PF05377.11 EMD58681.1 - 0.37 11.2 0.1 0.37 11.2 0.1 2.5 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) CLZ PF16526.5 EMD58681.1 - 0.43 11.0 0.0 0.43 11.0 0.0 3.0 2 1 1 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF1664 PF07889.12 EMD58681.1 - 0.58 10.2 3.3 3.6 7.7 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Takusan PF04822.13 EMD58681.1 - 0.92 9.4 7.1 1.4 8.9 0.1 2.3 2 0 0 2 2 2 0 Takusan DUF5320 PF17253.2 EMD58681.1 - 1.5 10.0 3.9 31 5.7 0.0 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5320) JIP_LZII PF16471.5 EMD58681.1 - 1.7 8.9 12.0 4.7 7.5 0.4 2.4 2 1 0 2 2 2 0 JNK-interacting protein leucine zipper II MFS_1 PF07690.16 EMD58682.1 - 1.3e-41 142.7 37.3 1.3e-41 142.7 37.3 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EMD58682.1 - 1.1e-11 44.2 11.4 1.1e-11 44.2 11.4 2.3 2 0 0 2 2 2 1 Sugar (and other) transporter PhyH PF05721.13 EMD58683.1 - 1.9e-06 28.3 0.5 5.8e-06 26.7 0.1 2.0 2 1 0 2 2 2 1 Phytanoyl-CoA dioxygenase (PhyH) Ribosomal_S25 PF03297.15 EMD58684.1 - 2.9e-37 126.9 4.5 3.2e-37 126.8 4.5 1.0 1 0 0 1 1 1 1 S25 ribosomal protein Rrf2 PF02082.20 EMD58684.1 - 0.036 14.4 0.1 0.052 13.9 0.1 1.2 1 0 0 1 1 1 0 Transcriptional regulator HTH_DeoR PF08220.12 EMD58684.1 - 0.05 13.4 0.1 0.069 12.9 0.1 1.2 1 0 0 1 1 1 0 DeoR-like helix-turn-helix domain HTH_11 PF08279.12 EMD58684.1 - 0.054 13.4 0.1 0.076 13.0 0.1 1.2 1 0 0 1 1 1 0 HTH domain UL45 PF05473.12 EMD58688.1 - 0.041 13.5 0.1 0.11 12.1 0.1 1.7 1 0 0 1 1 1 0 UL45 protein, carbohydrate-binding C-type lectin-like RAMP4 PF06624.12 EMD58688.1 - 0.47 10.5 1.9 4.8 7.3 0.0 2.4 2 0 0 2 2 2 0 Ribosome associated membrane protein RAMP4 Cyt-b5 PF00173.28 EMD58689.1 - 1.7e-10 40.9 0.0 2.5e-10 40.4 0.0 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Gtr1_RagA PF04670.12 EMD58690.1 - 1.9e-71 240.1 0.0 2.8e-71 239.6 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Arf PF00025.21 EMD58690.1 - 3.2e-05 23.4 0.0 5.1e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EMD58690.1 - 0.0014 18.7 0.0 0.0039 17.3 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EMD58690.1 - 0.0019 17.8 0.0 0.0032 17.1 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 EMD58690.1 - 0.018 14.5 0.0 0.032 13.7 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Roc PF08477.13 EMD58690.1 - 0.037 14.2 0.0 0.075 13.3 0.0 1.6 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.6 EMD58690.1 - 0.043 14.2 0.2 0.11 12.9 0.0 1.9 2 1 0 2 2 2 0 AAA ATPase domain AAA_14 PF13173.6 EMD58690.1 - 0.062 13.3 0.0 0.23 11.5 0.0 1.9 2 0 0 2 2 2 0 AAA domain DUF2834 PF11196.8 EMD58691.1 - 0.032 14.6 12.6 1.1 9.7 0.1 4.3 3 1 1 4 4 4 0 Protein of unknown function (DUF2834) Na_H_antiport_1 PF06965.12 EMD58691.1 - 0.29 10.0 3.7 1.3 7.8 0.0 2.6 3 0 0 3 3 3 0 Na+/H+ antiporter 1 AT_hook PF02178.19 EMD58691.1 - 0.61 10.2 4.3 1.4 9.0 4.3 1.6 1 0 0 1 1 1 0 AT hook motif BCNT PF07572.12 EMD58692.1 - 7.3e-23 80.4 0.5 1.6e-22 79.4 0.5 1.5 1 0 0 1 1 1 1 Bucentaur or craniofacial development RdRP PF05183.12 EMD58693.1 - 5.1e-130 434.9 0.0 6.8e-130 434.5 0.0 1.1 1 0 0 1 1 1 1 RNA dependent RNA polymerase TCTP PF00838.17 EMD58694.1 - 2.8e-70 236.0 3.0 3.1e-70 235.8 3.0 1.0 1 0 0 1 1 1 1 Translationally controlled tumour protein Glyco_hydro_106 PF17132.4 EMD58694.1 - 0.033 12.5 0.1 0.044 12.1 0.1 1.1 1 0 0 1 1 1 0 alpha-L-rhamnosidase FA_hydroxylase PF04116.13 EMD58695.1 - 1.4e-20 74.0 10.7 1.4e-20 74.0 10.7 1.7 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily VWA PF00092.28 EMD58697.1 - 1e-07 32.4 0.0 5.2e-07 30.1 0.0 2.0 1 1 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 EMD58697.1 - 1.8e-05 25.3 0.0 3.5e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain vWA-TerF-like PF10138.9 EMD58697.1 - 0.00059 20.0 0.0 0.00087 19.4 0.0 1.3 1 0 0 1 1 1 1 vWA found in TerF C terminus DUF98 PF01947.16 EMD58699.1 - 0.068 13.1 0.0 0.084 12.8 0.0 1.1 1 0 0 1 1 1 0 p-hydroxybenzoic acid synthase Iso_dh PF00180.20 EMD58700.1 - 1.4e-122 409.2 0.0 1.6e-122 409.0 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase HET PF06985.11 EMD58703.1 - 1.5e-21 77.3 0.0 3.8e-21 76.0 0.0 1.7 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Peptidase_S10 PF00450.22 EMD58704.1 - 2.6e-129 432.3 1.9 3.1e-129 432.0 1.9 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase Carbpep_Y_N PF05388.11 EMD58704.1 - 3.6e-16 59.8 1.4 1e-15 58.4 1.4 1.8 1 1 0 1 1 1 1 Carboxypeptidase Y pro-peptide SBDS_C PF09377.10 EMD58705.1 - 1e-41 141.5 1.7 2.1e-41 140.5 0.2 2.0 2 0 0 2 2 2 1 SBDS protein C-terminal domain SBDS PF01172.18 EMD58705.1 - 6.4e-33 112.7 1.2 1.2e-32 111.8 1.2 1.5 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein Tim54 PF11711.8 EMD58706.1 - 0.038 12.8 0.8 0.048 12.5 0.8 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 PI3K_1B_p101 PF10486.9 EMD58706.1 - 0.67 7.7 9.5 0.77 7.5 9.5 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit ALS2CR11 PF15729.5 EMD58706.1 - 0.82 8.7 6.0 2.4 7.2 5.1 1.8 1 1 0 2 2 2 0 Amyotrophic lateral sclerosis 2 candidate 11 Ribosomal_S13 PF00416.22 EMD58707.1 - 7.3e-54 181.6 2.0 8.6e-54 181.3 2.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S13/S18 FbpA PF05833.11 EMD58707.1 - 0.014 14.2 0.0 0.015 14.1 0.0 1.2 1 0 0 1 1 1 0 Fibronectin-binding protein A N-terminus (FbpA) PP28 PF10252.9 EMD58707.1 - 0.055 13.9 0.2 0.12 12.8 0.2 1.5 1 0 0 1 1 1 0 Casein kinase substrate phosphoprotein PP28 Zn_ribbon_SprT PF17283.2 EMD58708.1 - 0.093 12.7 4.6 0.23 11.4 4.6 1.7 1 0 0 1 1 1 0 SprT-like zinc ribbon domain DUF4313 PF14190.6 EMD58709.1 - 0.16 12.0 0.0 0.29 11.1 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4313) SnoaL PF07366.12 EMD58710.1 - 0.00011 22.0 0.0 0.00024 20.9 0.0 1.6 1 0 0 1 1 1 1 SnoaL-like polyketide cyclase SnoaL_2 PF12680.7 EMD58710.1 - 0.021 15.4 0.0 0.066 13.9 0.0 1.9 1 0 0 1 1 1 0 SnoaL-like domain DLH PF01738.18 EMD58710.1 - 0.16 11.5 0.0 0.3 10.6 0.0 1.4 1 0 0 1 1 1 0 Dienelactone hydrolase family PAP_central PF04928.17 EMD58712.1 - 9e-101 336.0 0.0 1.1e-100 335.7 0.0 1.1 1 0 0 1 1 1 1 Poly(A) polymerase central domain PAP_RNA-bind PF04926.15 EMD58712.1 - 1.3e-49 168.1 0.0 2e-49 167.5 0.0 1.3 1 0 0 1 1 1 1 Poly(A) polymerase predicted RNA binding domain NTP_transf_2 PF01909.23 EMD58712.1 - 9.8e-10 38.6 0.0 3.2e-09 36.9 0.0 1.8 1 0 0 1 1 1 1 Nucleotidyltransferase domain YlbD_coat PF14071.6 EMD58712.1 - 0.01 16.1 0.3 0.41 10.9 0.0 2.5 2 0 0 2 2 2 0 Putative coat protein Polbeta PF18765.1 EMD58712.1 - 0.012 15.7 0.0 0.027 14.5 0.0 1.5 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase DUF4143 PF13635.6 EMD58712.1 - 0.11 12.7 0.0 0.2 11.8 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4143) 2_5_RNA_ligase2 PF13563.6 EMD58713.1 - 2.1e-12 47.2 0.1 2.4e-12 47.0 0.1 1.1 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily Abhydrolase_1 PF00561.20 EMD58714.1 - 5.4e-10 39.3 0.1 1e-09 38.4 0.1 1.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EMD58714.1 - 0.015 14.6 0.0 0.57 9.4 0.0 2.1 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EMD58714.1 - 0.019 15.6 0.0 0.023 15.3 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family MatE PF01554.18 EMD58715.1 - 6.2e-56 188.5 33.1 1.8e-34 118.7 11.1 2.4 2 0 0 2 2 2 2 MatE Polysacc_synt_C PF14667.6 EMD58715.1 - 0.0053 16.8 17.5 0.0053 16.8 17.5 4.1 2 1 3 5 5 5 2 Polysaccharide biosynthesis C-terminal domain Cation_ATPase_C PF00689.21 EMD58716.1 - 2.9e-37 128.2 5.2 2.9e-37 128.2 5.2 2.9 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 EMD58716.1 - 1.9e-36 125.3 1.8 1.9e-36 125.3 1.8 2.7 4 0 0 4 4 4 1 E1-E2 ATPase Hydrolase PF00702.26 EMD58716.1 - 1.7e-18 67.7 0.0 1.5e-16 61.3 0.0 3.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EMD58716.1 - 4.3e-18 65.2 0.0 8.6e-18 64.2 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EMD58716.1 - 0.1 12.3 0.0 0.33 10.6 0.0 1.8 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase NrsF PF06532.11 EMD58716.1 - 7.4 6.2 11.1 10 5.8 0.2 2.8 3 0 0 3 3 3 0 Negative regulator of sigma F DivIC PF04977.15 EMD58719.1 - 0.0075 16.0 0.0 0.0086 15.8 0.0 1.1 1 0 0 1 1 1 1 Septum formation initiator TSC22 PF01166.18 EMD58719.1 - 0.018 15.4 0.1 0.023 15.0 0.1 1.2 1 0 0 1 1 1 0 TSC-22/dip/bun family Filament PF00038.21 EMD58719.1 - 0.031 13.9 0.0 0.031 13.9 0.0 1.0 1 0 0 1 1 1 0 Intermediate filament protein YabA PF06156.13 EMD58719.1 - 0.075 13.7 0.0 0.075 13.7 0.0 1.1 1 0 0 1 1 1 0 Initiation control protein YabA NRBF2 PF08961.10 EMD58719.1 - 0.089 12.4 0.8 0.095 12.3 0.5 1.3 1 1 0 1 1 1 0 Nuclear receptor-binding factor 2, autophagy regulator GIT_CC PF16559.5 EMD58719.1 - 0.15 12.0 0.8 0.19 11.6 0.8 1.2 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor zf-PHD-like PF15446.6 EMD58721.1 - 0.025 14.2 1.7 0.031 13.9 1.7 1.2 1 0 0 1 1 1 0 PHD/FYVE-zinc-finger like domain Zn_clus PF00172.18 EMD58721.1 - 0.2 11.8 6.5 0.58 10.3 6.5 1.7 1 1 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF3157 PF11355.8 EMD58723.1 - 0.12 12.0 0.0 0.14 11.7 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3157) FoP_duplication PF13865.6 EMD58724.1 - 0.24 12.0 10.2 0.047 14.2 3.1 2.3 2 0 0 2 2 2 0 C-terminal duplication domain of Friend of PRMT1 F5_F8_type_C PF00754.25 EMD58727.1 - 2e-06 28.0 0.2 4.5e-06 26.8 0.2 1.5 1 0 0 1 1 1 1 F5/8 type C domain GDE_C PF06202.14 EMD58727.1 - 6e-06 25.4 0.1 9e-06 24.9 0.1 1.2 1 0 0 1 1 1 1 Amylo-alpha-1,6-glucosidase Trehalase PF01204.18 EMD58727.1 - 0.0084 15.0 0.2 0.013 14.3 0.2 1.2 1 0 0 1 1 1 1 Trehalase Bd3614_N PF14442.6 EMD58727.1 - 0.37 11.1 3.3 0.97 9.8 3.3 1.7 1 0 0 1 1 1 0 Bd3614-like deaminase N-terminal GAT PF03127.14 EMD58729.1 - 1.5e-17 63.7 0.1 3.2e-17 62.6 0.1 1.6 1 0 0 1 1 1 1 GAT domain VHS PF00790.19 EMD58729.1 - 0.0027 17.6 0.0 0.0049 16.7 0.0 1.4 1 0 0 1 1 1 1 VHS domain DUF2183 PF09949.9 EMD58730.1 - 3.1e-31 107.6 0.0 6.6e-31 106.6 0.0 1.6 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2183) Menin PF05053.13 EMD58731.1 - 0.25 9.7 0.3 0.22 9.9 0.3 1.0 1 0 0 1 1 1 0 Menin EVI2A PF05399.11 EMD58731.1 - 0.59 9.7 4.9 0.71 9.4 4.9 1.1 1 0 0 1 1 1 0 Ectropic viral integration site 2A protein (EVI2A) Cytochrom_B561 PF03188.16 EMD58732.1 - 1.1e-05 25.6 11.1 2.2e-05 24.6 11.1 1.5 1 1 0 1 1 1 1 Eukaryotic cytochrome b561 DUF2427 PF10348.9 EMD58732.1 - 0.00062 19.5 4.6 0.0022 17.8 2.8 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF2427) PDEase_II PF02112.15 EMD58733.1 - 1.2e-50 172.6 0.0 2.3e-22 79.6 0.0 3.4 3 0 0 3 3 3 3 cAMP phosphodiesterases class-II EF1G PF00647.19 EMD58733.1 - 2.7e-45 152.8 0.1 5.1e-45 151.9 0.1 1.5 1 0 0 1 1 1 1 Elongation factor 1 gamma, conserved domain GST_N PF02798.20 EMD58733.1 - 2.2e-13 50.3 0.3 2.5e-12 46.9 0.0 2.9 3 0 0 3 3 3 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EMD58733.1 - 4.8e-12 45.9 0.0 1.3e-11 44.6 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EMD58733.1 - 7.2e-09 35.5 0.8 1.6e-08 34.4 0.0 2.1 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EMD58733.1 - 6.3e-07 29.7 0.0 1.5e-06 28.5 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EMD58733.1 - 0.00038 20.6 0.0 0.00088 19.4 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 EMD58733.1 - 0.018 15.3 0.0 0.05 13.9 0.0 1.8 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain Lactamase_B PF00753.27 EMD58733.1 - 0.025 14.6 0.1 0.19 11.7 0.1 2.3 2 0 0 2 2 2 0 Metallo-beta-lactamase superfamily GST_C_6 PF17171.4 EMD58733.1 - 0.028 14.2 0.0 5.1 7.0 0.0 2.7 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain Ribosomal_S9 PF00380.19 EMD58734.1 - 6.5e-42 142.9 0.2 1.2e-41 142.1 0.2 1.4 1 0 0 1 1 1 1 Ribosomal protein S9/S16 Synthase_beta PF11421.8 EMD58737.1 - 0.83 10.4 6.7 2.4 8.9 4.3 2.8 2 0 0 2 2 2 0 ATP synthase F1 beta subunit EHN PF06441.12 EMD58739.1 - 6.6e-31 106.9 0.2 1.2e-30 106.0 0.2 1.5 1 0 0 1 1 1 1 Epoxide hydrolase N terminus Abhydrolase_1 PF00561.20 EMD58739.1 - 6.6e-09 35.8 0.0 1.2e-08 35.0 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EMD58739.1 - 0.0018 18.9 0.6 0.019 15.6 0.6 2.2 1 1 0 1 1 1 1 Alpha/beta hydrolase family Glyco_hydro_76 PF03663.14 EMD58740.1 - 3.6e-144 480.8 9.6 4.2e-144 480.6 9.6 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 SUZ PF12752.7 EMD58742.1 - 0.32 11.8 0.1 0.32 11.8 0.1 2.4 3 0 0 3 3 3 0 SUZ domain zf-C2H2 PF00096.26 EMD58743.1 - 0.041 14.3 4.1 0.041 14.3 4.1 2.5 2 0 0 2 2 2 0 Zinc finger, C2H2 type EST1_DNA_bind PF10373.9 EMD58744.1 - 9.5e-68 228.7 0.0 1.6e-67 228.0 0.0 1.4 1 0 0 1 1 1 1 Est1 DNA/RNA binding domain EST1 PF10374.9 EMD58744.1 - 2.2e-17 63.9 4.1 2.5e-17 63.8 2.8 1.7 2 0 0 2 2 2 1 Telomerase activating protein Est1 Pan3_PK PF18101.1 EMD58745.1 - 2.5e-54 183.0 0.1 9.3e-54 181.2 0.1 1.9 1 1 0 1 1 1 1 Pan3 Pseudokinase domain Pkinase PF00069.25 EMD58745.1 - 1.1e-06 28.2 0.0 1.8e-06 27.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain zf-CCCH PF00642.24 EMD58745.1 - 0.00096 19.0 0.7 0.0017 18.2 0.7 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) PfkB PF00294.24 EMD58746.1 - 3.2e-72 243.4 0.4 3.6e-72 243.2 0.4 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.12 EMD58746.1 - 6.3e-06 25.7 0.0 3e-05 23.5 0.0 2.0 2 0 0 2 2 2 1 Phosphomethylpyrimidine kinase UBX PF00789.20 EMD58747.1 - 2.7e-11 43.5 0.0 5.5e-11 42.5 0.0 1.6 1 0 0 1 1 1 1 UBX domain UBA_4 PF14555.6 EMD58747.1 - 1.9e-10 40.3 0.2 4.7e-10 39.1 0.2 1.7 1 0 0 1 1 1 1 UBA-like domain Atg14 PF10186.9 EMD58747.1 - 0.0093 15.1 4.6 0.014 14.5 4.6 1.3 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 Med19 PF10278.9 EMD58747.1 - 0.049 13.6 2.0 0.085 12.8 2.0 1.3 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 DUF1682 PF07946.14 EMD58747.1 - 0.066 12.4 8.6 0.095 11.9 7.3 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1682) CAF-1_p150 PF11600.8 EMD58747.1 - 0.12 12.1 16.9 0.25 11.1 16.9 1.4 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal U1snRNP70_N PF12220.8 EMD58747.1 - 5.6 7.7 10.1 18 6.0 10.1 1.9 1 0 0 1 1 1 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DDRGK PF09756.9 EMD58747.1 - 9.2 5.8 19.3 16 5.0 19.3 1.3 1 0 0 1 1 1 0 DDRGK domain MFS_1 PF07690.16 EMD58748.1 - 9.2e-29 100.5 42.0 1.7e-28 99.6 41.8 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily Orf78 PF06024.12 EMD58748.1 - 0.067 13.5 0.0 0.17 12.2 0.0 1.6 1 0 0 1 1 1 0 Orf78 (ac78) SPRY PF00622.28 EMD58749.1 - 1.8e-19 70.0 0.1 3e-19 69.3 0.1 1.4 1 0 0 1 1 1 1 SPRY domain DUF3611 PF12263.8 EMD58749.1 - 0.14 12.1 0.0 0.23 11.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3611) HEAT_EZ PF13513.6 EMD58750.1 - 8.3e-30 102.8 13.5 8.4e-13 48.5 0.0 10.0 9 2 3 12 12 10 5 HEAT-like repeat HEAT PF02985.22 EMD58750.1 - 3.9e-24 82.7 11.0 0.00022 21.2 0.0 10.5 11 0 0 11 11 10 4 HEAT repeat HEAT_2 PF13646.6 EMD58750.1 - 1.6e-16 60.4 2.4 0.00011 22.5 0.0 7.1 6 1 1 7 7 7 4 HEAT repeats Cnd1 PF12717.7 EMD58750.1 - 6.5e-12 45.8 0.4 0.047 13.7 0.0 5.3 5 1 0 5 5 5 3 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 EMD58750.1 - 2.5e-11 44.0 0.0 0.05 14.2 0.0 6.5 5 1 0 6 6 5 2 Vacuolar 14 Fab1-binding region Arm PF00514.23 EMD58750.1 - 1.5e-07 31.2 0.5 3.7 7.7 0.0 6.2 6 0 0 6 6 6 2 Armadillo/beta-catenin-like repeat IBN_N PF03810.19 EMD58750.1 - 3.7e-07 30.0 0.1 8.7e-05 22.4 0.0 3.9 2 1 0 2 2 2 1 Importin-beta N-terminal domain MMS19_C PF12460.8 EMD58750.1 - 6.6e-07 28.8 0.4 0.71 8.9 0.0 4.6 6 0 0 6 6 6 2 RNAPII transcription regulator C-terminal CLASP_N PF12348.8 EMD58750.1 - 6.2e-06 25.9 0.1 35 3.9 0.0 6.9 4 2 1 7 7 7 0 CLASP N terminal DRIM PF07539.12 EMD58750.1 - 3.6e-05 22.3 0.0 0.48 8.7 0.0 4.3 3 1 1 5 5 5 2 Down-regulated in metastasis RTP1_C1 PF10363.9 EMD58750.1 - 7e-05 23.0 0.0 0.011 15.9 0.0 3.7 4 0 0 4 4 4 1 Required for nuclear transport of RNA pol II C-terminus 1 TAF6_C PF07571.13 EMD58750.1 - 0.0035 17.6 0.0 6.2 7.2 0.0 4.4 4 1 0 4 4 4 1 TAF6 C-terminal HEAT repeat domain DUF3437 PF11919.8 EMD58750.1 - 0.0046 16.9 0.1 6.6 6.7 0.0 4.4 4 0 0 4 4 4 1 Domain of unknown function (DUF3437) Tti2 PF10521.9 EMD58750.1 - 0.005 16.4 0.0 0.93 9.0 0.0 3.0 2 0 0 2 2 2 1 Tti2 family Xpo1 PF08389.12 EMD58750.1 - 0.039 14.0 0.0 2.9 7.9 0.0 3.0 1 1 0 1 1 1 0 Exportin 1-like protein BRCC36_C PF18110.1 EMD58750.1 - 0.059 13.5 0.0 0.15 12.2 0.0 1.6 1 0 0 1 1 1 0 BRCC36 C-terminal helical domain MMS19_N PF14500.6 EMD58750.1 - 0.075 12.6 0.0 26 4.3 0.0 3.1 3 0 0 3 3 3 0 Dos2-interacting transcription regulator of RNA-Pol-II RIX1 PF08167.12 EMD58750.1 - 0.078 12.7 0.1 8.7 6.0 0.0 3.4 3 0 0 3 3 3 0 rRNA processing/ribosome biogenesis DUF4003 PF13170.6 EMD58750.1 - 0.093 12.1 0.2 2.5 7.4 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4003) HEAT_PBS PF03130.16 EMD58750.1 - 0.11 13.2 3.7 77 4.4 0.0 5.0 4 0 0 4 4 3 0 PBS lyase HEAT-like repeat TIP120 PF08623.10 EMD58750.1 - 0.17 11.6 0.1 26 4.5 0.0 3.5 4 0 0 4 4 4 0 TATA-binding protein interacting (TIP20) Telomere_reg-2 PF10193.9 EMD58750.1 - 0.19 12.2 0.5 2.8 8.4 0.0 3.0 3 1 0 3 3 2 0 Telomere length regulation protein NTR2 PF15458.6 EMD58750.1 - 0.56 9.7 2.4 1 8.9 2.4 1.3 1 0 0 1 1 1 0 Nineteen complex-related protein 2 Cnd2 PF05786.14 EMD58750.1 - 0.68 8.5 5.6 1 7.9 5.6 1.1 1 0 0 1 1 1 0 Condensin complex subunit 2 PBP1_TM PF14812.6 EMD58751.1 - 0.00037 20.8 5.8 0.00037 20.8 5.8 1.5 2 0 0 2 2 2 1 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF5320 PF17253.2 EMD58751.1 - 0.12 13.4 12.6 0.4 11.8 0.2 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5320) FAM176 PF14851.6 EMD58751.1 - 0.41 10.3 0.8 0.71 9.5 0.8 1.3 1 0 0 1 1 1 0 FAM176 family IATP PF04568.12 EMD58751.1 - 4.7 7.7 7.1 19 5.7 0.4 2.4 2 0 0 2 2 2 0 Mitochondrial ATPase inhibitor, IATP Zn_clus PF00172.18 EMD58752.1 - 2.2e-08 34.1 11.8 3.5e-08 33.4 11.8 1.2 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EMD58752.1 - 1.5e-07 30.6 2.0 2.6e-07 29.8 2.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain CCDC92 PF14916.6 EMD58752.1 - 0.14 12.0 0.7 16 5.4 0.2 2.5 2 0 0 2 2 2 0 Coiled-coil domain of unknown function MAGE_N PF12440.8 EMD58752.1 - 0.82 10.4 6.0 1.2 9.8 2.5 2.4 2 0 0 2 2 2 0 Melanoma associated antigen family N terminal Peptidase_C12 PF01088.21 EMD58754.1 - 4.3e-66 222.7 0.0 5.8e-66 222.2 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 UCH_C PF18031.1 EMD58754.1 - 1e-13 50.9 0.2 2.6e-13 49.6 0.2 1.6 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolases BfiI_DBD PF18243.1 EMD58754.1 - 0.11 12.1 0.0 0.21 11.2 0.0 1.4 1 0 0 1 1 1 0 Metal-independent restriction enzyme BfiI DNA binding domain FUSC PF04632.12 EMD58755.1 - 0.035 12.6 11.0 0.05 12.1 11.0 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family Atg14 PF10186.9 EMD58755.1 - 0.49 9.4 10.6 0.91 8.5 10.6 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 EMP24_GP25L PF01105.24 EMD58755.1 - 0.67 9.9 3.1 0.27 11.2 0.1 1.8 2 0 0 2 2 2 0 emp24/gp25L/p24 family/GOLD KNOX2 PF03791.13 EMD58755.1 - 1 8.9 13.5 5.5 6.6 0.8 3.5 3 0 0 3 3 3 0 KNOX2 domain Exonuc_VII_L PF02601.15 EMD58755.1 - 1.7 8.2 13.1 3 7.3 13.1 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit HSP70 PF00012.20 EMD58756.1 - 1e-64 218.8 3.7 1.3e-59 202.0 0.3 3.8 2 1 2 4 4 4 2 Hsp70 protein SR-25 PF10500.9 EMD58756.1 - 0.00021 21.0 9.8 0.00021 21.0 9.8 3.3 2 1 0 3 3 3 1 Nuclear RNA-splicing-associated protein MreB_Mbl PF06723.13 EMD58756.1 - 0.024 13.5 0.1 0.06 12.2 0.1 1.6 1 0 0 1 1 1 0 MreB/Mbl protein DUF1117 PF06547.12 EMD58756.1 - 0.11 13.1 1.6 1.2 9.7 0.9 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1117) Clp_N PF02861.20 EMD58756.1 - 0.34 11.1 3.0 1.1e+02 3.1 0.0 4.1 3 0 0 3 3 3 0 Clp amino terminal domain, pathogenicity island component DUF3446 PF11928.8 EMD58756.1 - 0.48 10.8 11.9 0.68 10.3 6.3 3.0 2 0 0 2 2 2 0 Early growth response N-terminal domain Chorion_2 PF03964.15 EMD58756.1 - 4.4 8.2 9.0 2.9 8.8 4.4 2.8 2 0 0 2 2 2 0 Chorion family 2 Mtc PF03820.17 EMD58757.1 - 2.7e-121 404.4 0.0 3e-121 404.3 0.0 1.0 1 0 0 1 1 1 1 Tricarboxylate carrier Aminotran_1_2 PF00155.21 EMD58759.1 - 2e-17 63.4 0.0 2.7e-17 63.0 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.7 EMD58759.1 - 0.015 14.1 0.0 0.64 8.7 0.0 2.4 3 0 0 3 3 3 0 Alanine-glyoxylate amino-transferase Pectate_lyase_3 PF12708.7 EMD58761.1 - 6e-95 317.1 13.6 2.2e-83 279.3 7.2 2.7 2 1 0 2 2 2 2 Pectate lyase superfamily protein End_N_terminal PF12218.8 EMD58761.1 - 8.7e-08 31.8 1.9 0.0023 17.6 0.1 2.8 2 0 0 2 2 2 2 N terminal extension of bacteriophage endosialidase WD40 PF00400.32 EMD58762.1 - 1.7e-108 351.5 72.2 1.3e-10 41.6 0.5 12.6 12 0 0 12 12 12 11 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD58762.1 - 5.8e-40 135.5 18.8 0.0038 17.5 0.0 11.5 1 1 10 11 11 11 11 Anaphase-promoting complex subunit 4 WD40 domain NACHT PF05729.12 EMD58762.1 - 3.3e-28 98.7 0.1 6.3e-28 97.8 0.1 1.4 1 0 0 1 1 1 1 NACHT domain Ge1_WD40 PF16529.5 EMD58762.1 - 5.3e-17 61.8 39.6 0.003 16.6 1.1 8.8 1 1 7 8 8 8 7 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 EMD58762.1 - 4.7e-16 58.5 44.0 0.031 12.9 0.4 10.8 1 1 10 11 11 11 10 Nucleoporin Nup120/160 CDtoxinA PF03498.14 EMD58762.1 - 1.8e-13 50.4 0.1 0.25 10.9 0.1 7.1 1 1 7 8 8 8 6 Cytolethal distending toxin A/C domain HET PF06985.11 EMD58762.1 - 5.2e-11 43.1 8.7 2.6e-09 37.6 0.2 3.7 3 1 1 4 4 4 2 Heterokaryon incompatibility protein (HET) AAA_19 PF13245.6 EMD58762.1 - 0.16 12.3 0.0 0.32 11.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF5114 PF17141.4 EMD58762.1 - 2.9 8.5 6.6 1.3e+02 3.2 0.1 5.1 3 2 4 8 8 8 0 Domain of unknown function (DUF5114) Methyltr_RsmB-F PF01189.17 EMD58763.1 - 1.1e-18 67.7 0.0 1.2e-12 47.9 0.0 2.4 2 0 0 2 2 2 2 16S rRNA methyltransferase RsmB/F SAD_SRA PF02182.17 EMD58764.1 - 7.5e-06 25.7 0.0 1.8e-05 24.5 0.0 1.7 1 0 0 1 1 1 1 SAD/SRA domain AA_permease_2 PF13520.6 EMD58765.1 - 7.3e-44 150.3 50.3 9.8e-44 149.8 50.3 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EMD58765.1 - 6e-25 87.8 44.3 7.5e-25 87.5 44.3 1.0 1 0 0 1 1 1 1 Amino acid permease GAPT PF11770.8 EMD58765.1 - 0.21 11.4 0.3 0.44 10.4 0.3 1.5 1 0 0 1 1 1 0 GRB2-binding adapter (GAPT) CTV_P6 PF06706.11 EMD58765.1 - 1.3 8.8 7.4 0.41 10.4 0.5 3.1 2 0 0 2 2 2 0 Citrus tristeza virus 6-kDa protein Asp4 PF16996.5 EMD58765.1 - 4.5 7.1 4.5 13 5.6 0.1 2.8 3 0 0 3 3 3 0 Accessory secretory protein Sec Asp4 NACHT PF05729.12 EMD58768.1 - 4.2e-05 23.5 0.3 0.00015 21.7 0.0 2.0 2 1 0 2 2 2 1 NACHT domain AAA_22 PF13401.6 EMD58768.1 - 4.4e-05 23.8 0.1 0.0058 16.9 0.0 3.1 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EMD58768.1 - 8e-05 23.1 0.0 0.014 15.8 0.0 2.5 2 1 0 2 2 2 1 AAA ATPase domain KAP_NTPase PF07693.14 EMD58768.1 - 0.00056 19.2 2.3 0.0042 16.4 1.2 2.2 1 1 1 2 2 2 1 KAP family P-loop domain ATPase_2 PF01637.18 EMD58768.1 - 0.0022 17.9 0.1 0.0069 16.3 0.0 1.8 2 1 0 2 2 2 1 ATPase domain predominantly from Archaea RNA_helicase PF00910.22 EMD58768.1 - 0.0042 17.5 0.2 0.13 12.7 0.0 2.7 3 0 0 3 3 3 1 RNA helicase AAA_7 PF12775.7 EMD58768.1 - 0.013 15.1 0.0 0.23 10.9 0.0 2.5 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_30 PF13604.6 EMD58768.1 - 0.02 14.6 0.0 0.042 13.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 EMD58768.1 - 0.02 14.2 0.0 0.044 13.1 0.0 1.5 1 0 0 1 1 1 0 KaiC NB-ARC PF00931.22 EMD58768.1 - 0.023 13.9 0.0 0.089 12.0 0.0 2.0 2 0 0 2 2 2 0 NB-ARC domain AAA_29 PF13555.6 EMD58768.1 - 0.023 14.4 0.1 0.059 13.1 0.1 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.27 EMD58768.1 - 0.21 12.1 1.6 1.1 9.7 0.1 2.6 2 1 1 3 3 3 0 ABC transporter CDO_I PF05995.12 EMD58769.1 - 2.3e-43 147.4 0.0 2.9e-43 147.1 0.0 1.1 1 0 0 1 1 1 1 Cysteine dioxygenase type I PCO_ADO PF07847.12 EMD58769.1 - 0.0044 16.5 0.5 0.0074 15.8 0.4 1.4 1 1 0 1 1 1 1 PCO_ADO MecA PF05389.12 EMD58769.1 - 0.061 12.9 0.0 0.062 12.9 0.0 1.2 1 0 0 1 1 1 0 Negative regulator of genetic competence (MecA) MMR_HSR1_Xtn PF16897.5 EMD58770.1 - 1.6e-41 140.6 0.7 1.1e-40 137.9 0.2 2.3 2 0 0 2 2 2 1 C-terminal region of MMR_HSR1 domain TGS PF02824.21 EMD58770.1 - 3.9e-23 81.3 0.1 1e-22 79.9 0.1 1.8 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.23 EMD58770.1 - 3.7e-21 75.4 0.2 1.5e-20 73.3 0.0 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EMD58770.1 - 7.1e-10 38.6 0.1 3.4e-09 36.4 0.0 2.0 2 0 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EMD58770.1 - 0.00028 21.0 0.2 0.066 13.3 0.0 2.4 1 1 1 2 2 2 2 Dynamin family MeaB PF03308.16 EMD58770.1 - 0.006 15.6 0.1 0.018 14.0 0.1 1.8 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB RsgA_GTPase PF03193.16 EMD58770.1 - 0.033 14.1 1.3 2.8 7.8 0.1 3.2 2 1 1 3 3 3 0 RsgA GTPase AIG1 PF04548.16 EMD58770.1 - 0.059 12.7 0.0 0.098 12.0 0.0 1.3 1 0 0 1 1 1 0 AIG1 family Arf PF00025.21 EMD58770.1 - 0.12 11.8 0.2 2.4 7.6 0.0 2.2 2 0 0 2 2 2 0 ADP-ribosylation factor family HTH_Tnp_Tc5 PF03221.16 EMD58771.1 - 1.1e-14 54.2 0.2 1.9e-14 53.4 0.2 1.4 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain CENP-B_N PF04218.13 EMD58771.1 - 2.8e-07 30.1 0.0 8e-07 28.6 0.0 1.7 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain HTH_Crp_2 PF13545.6 EMD58771.1 - 0.012 15.5 0.0 0.027 14.4 0.0 1.5 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain HTH_38 PF13936.6 EMD58771.1 - 0.03 14.1 0.0 0.05 13.4 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain MarR PF01047.22 EMD58771.1 - 0.039 13.9 0.0 0.12 12.3 0.0 1.8 1 0 0 1 1 1 0 MarR family HTH_Tnp_4 PF13613.6 EMD58771.1 - 0.087 12.6 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix of DDE superfamily endonuclease Herpes_LMP1 PF05297.11 EMD58772.1 - 0.84 8.8 2.8 1 8.5 2.8 1.1 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) PXA PF02194.15 EMD58775.1 - 3.2e-47 160.9 0.0 5.5e-47 160.1 0.0 1.4 1 0 0 1 1 1 1 PXA domain Med10 PF09748.9 EMD58776.1 - 8e-38 129.1 2.7 9.2e-38 128.9 2.7 1.0 1 0 0 1 1 1 1 Transcription factor subunit Med10 of Mediator complex DUF3877 PF12993.7 EMD58776.1 - 0.00028 20.8 0.1 0.0004 20.3 0.1 1.3 1 1 0 1 1 1 1 Domain of unknown function, E. rectale Gene description (DUF3877) Flagellin_N PF00669.20 EMD58776.1 - 0.00094 19.3 1.0 0.0015 18.6 0.3 1.6 2 0 0 2 2 2 1 Bacterial flagellin N-terminal helical region DUF3141 PF11339.8 EMD58776.1 - 0.032 12.7 1.0 0.037 12.5 1.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3141) Snapin_Pallidin PF14712.6 EMD58776.1 - 0.035 14.5 2.0 4.4 7.8 0.4 2.7 2 1 0 2 2 2 0 Snapin/Pallidin Syntaxin_2 PF14523.6 EMD58776.1 - 0.046 14.1 0.4 0.68 10.3 0.1 2.1 2 0 0 2 2 2 0 Syntaxin-like protein dCache_2 PF08269.11 EMD58776.1 - 0.058 12.6 0.8 0.11 11.7 0.2 1.6 2 0 0 2 2 2 0 Cache domain TAFH PF07531.14 EMD58776.1 - 0.061 13.4 0.4 2.2 8.4 0.3 2.5 1 1 1 2 2 2 0 NHR1 homology to TAF DUF445 PF04286.12 EMD58776.1 - 0.074 12.9 0.3 0.12 12.2 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF445) RNA_pol_Rpb4 PF03874.16 EMD58776.1 - 0.083 13.2 0.1 0.12 12.7 0.1 1.4 1 1 0 1 1 1 0 RNA polymerase Rpb4 ImcF-related_N PF14331.6 EMD58776.1 - 0.091 12.1 0.1 1.2 8.5 0.0 1.9 2 0 0 2 2 2 0 ImcF-related N-terminal domain Tropomyosin PF00261.20 EMD58776.1 - 0.11 11.8 0.3 0.8 9.0 0.0 1.9 2 0 0 2 2 2 0 Tropomyosin sCache_2 PF17200.4 EMD58776.1 - 0.18 11.6 2.0 0.18 11.7 0.8 1.6 2 0 0 2 2 2 0 Single Cache domain 2 DUF5344 PF17279.2 EMD58776.1 - 0.34 11.5 3.5 4.3 8.0 0.1 2.5 2 1 0 2 2 2 0 Family of unknown function (DUF5344) Glyco_transf_90 PF05686.12 EMD58777.1 - 6.1e-11 41.9 3.5 3.5e-06 26.2 2.9 4.0 3 1 0 3 3 3 3 Glycosyl transferase family 90 DUF5069 PF16798.5 EMD58777.1 - 0.13 12.5 0.0 0.33 11.1 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5069) zf-C2H2 PF00096.26 EMD58778.1 - 0.012 16.0 3.3 0.039 14.4 3.3 2.0 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMD58778.1 - 0.2 12.2 1.4 11 6.6 0.1 2.5 2 0 0 2 2 2 0 Zinc-finger double domain Ras PF00071.22 EMD58781.1 - 5.7e-57 191.8 0.0 6.9e-57 191.6 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMD58781.1 - 2.2e-34 118.3 0.0 3.3e-34 117.7 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMD58781.1 - 2.8e-14 53.0 0.0 5e-14 52.1 0.0 1.5 1 1 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EMD58781.1 - 4.6e-06 26.1 0.0 5.8e-06 25.8 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EMD58781.1 - 9.7e-06 25.2 0.0 1.6e-05 24.6 0.0 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EMD58781.1 - 3.3e-05 23.9 0.0 5e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 EMD58781.1 - 7e-05 23.3 0.3 0.00011 22.6 0.3 1.4 1 1 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 EMD58781.1 - 0.08 12.8 0.0 1.2 9.0 0.0 2.2 2 1 0 2 2 2 0 RsgA GTPase TniB PF05621.11 EMD58781.1 - 0.11 11.9 0.0 0.19 11.1 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein PTS_2-RNA PF01885.16 EMD58782.1 - 8.4e-67 224.7 0.0 1e-66 224.5 0.0 1.1 1 0 0 1 1 1 1 RNA 2'-phosphotransferase, Tpt1 / KptA family Glyco_tranf_2_3 PF13641.6 EMD58783.1 - 2.7e-26 92.9 0.0 4.2e-26 92.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 EMD58783.1 - 1.2e-10 41.7 0.8 1.2e-10 41.7 0.8 2.3 2 0 0 2 2 2 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.26 EMD58783.1 - 2.4e-05 24.2 0.0 4.1e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 EMD58783.1 - 0.00018 21.0 0.0 0.00033 20.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glyco_tranf_2_4 PF13704.6 EMD58783.1 - 0.16 12.5 0.0 30 5.2 0.0 2.4 2 0 0 2 2 2 0 Glycosyl transferase family 2 Herpes_LMP2 PF07415.11 EMD58784.1 - 0.057 12.2 0.2 0.072 11.9 0.2 1.1 1 0 0 1 1 1 0 Gammaherpesvirus latent membrane protein (LMP2) protein SnoaL_2 PF12680.7 EMD58785.1 - 0.011 16.3 0.1 0.015 15.9 0.1 1.3 1 0 0 1 1 1 0 SnoaL-like domain Pro_CA PF00484.19 EMD58786.1 - 3e-50 170.6 0.0 4.3e-50 170.0 0.0 1.2 1 0 0 1 1 1 1 Carbonic anhydrase OHA PF14418.6 EMD58786.1 - 0.14 12.0 0.0 0.3 10.9 0.0 1.6 1 0 0 1 1 1 0 OST-HTH Associated domain DUF3253 PF11625.8 EMD58787.1 - 2.1e-27 95.1 0.4 2.5e-27 94.9 0.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3253) DUF4476 PF14771.6 EMD58788.1 - 0.086 13.2 0.0 0.21 11.9 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4476) SHE3 PF17078.5 EMD58789.1 - 0.00012 21.9 1.6 0.00014 21.7 1.6 1.1 1 0 0 1 1 1 1 SWI5-dependent HO expression protein 3 Apolipoprotein PF01442.18 EMD58789.1 - 0.0031 17.4 8.6 0.0042 17.0 8.6 1.1 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain NAD_binding_4 PF07993.12 EMD58789.1 - 0.0048 16.1 0.2 0.0055 15.9 0.2 1.1 1 0 0 1 1 1 1 Male sterility protein DUF883 PF05957.13 EMD58789.1 - 0.0096 16.5 13.3 0.27 11.8 5.3 2.3 1 1 1 2 2 2 2 Bacterial protein of unknown function (DUF883) DUF5427 PF10310.9 EMD58789.1 - 0.046 12.7 4.3 0.051 12.5 4.3 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5427) ApoO PF09769.9 EMD58789.1 - 0.066 13.2 1.5 0.15 12.0 1.2 1.7 1 1 1 2 2 2 0 Apolipoprotein O Phasin PF05597.11 EMD58789.1 - 0.32 11.0 8.4 1.3 9.1 1.2 2.1 1 1 1 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) SCAB_CC PF16712.5 EMD58789.1 - 0.47 10.3 6.5 0.62 9.9 6.1 1.5 1 1 0 1 1 1 0 Coiled-coil regions of plant-specific actin-binding protein DUF4449 PF14613.6 EMD58789.1 - 0.65 10.1 6.4 0.97 9.5 6.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4449) RRF PF01765.19 EMD58789.1 - 5.3 7.0 9.7 15 5.5 9.3 1.8 1 1 0 1 1 1 0 Ribosome recycling factor SOAR PF16533.5 EMD58789.1 - 5.7 7.0 7.9 6.3 6.8 0.8 2.3 1 1 1 2 2 2 0 STIM1 Orai1-activating region YtxH PF12732.7 EMD58789.1 - 7.4 7.2 11.8 61 4.2 11.8 2.3 1 1 0 1 1 1 0 YtxH-like protein CDT1_C PF16679.5 EMD58790.1 - 6.7e-21 74.5 0.0 1.7e-20 73.2 0.0 1.7 1 0 0 1 1 1 1 DNA replication factor Cdt1 C-terminal domain AT_hook PF02178.19 EMD58790.1 - 0.026 14.3 2.7 0.084 12.8 2.7 1.9 1 0 0 1 1 1 0 AT hook motif Helicase_Sgs1 PF11408.8 EMD58790.1 - 0.14 12.2 0.0 0.31 11.1 0.0 1.5 1 0 0 1 1 1 0 Sgs1 RecQ helicase DUF4267 PF14087.6 EMD58791.1 - 0.0021 18.1 0.4 0.0027 17.7 0.4 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4267) TPP_enzyme_N PF02776.18 EMD58792.1 - 1.4e-30 106.1 0.0 3e-30 105.1 0.0 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 EMD58792.1 - 1e-21 77.1 0.1 2.5e-21 75.9 0.1 1.7 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 EMD58792.1 - 2.7e-12 46.7 1.2 5e-11 42.6 0.0 2.7 3 0 0 3 3 3 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Dioxygenase_C PF00775.21 EMD58793.1 - 1.5e-49 167.9 0.0 2e-49 167.5 0.0 1.2 1 0 0 1 1 1 1 Dioxygenase Dioxygenase_N PF04444.14 EMD58793.1 - 1.7e-26 91.8 0.1 2.6e-26 91.2 0.1 1.3 1 0 0 1 1 1 1 Catechol dioxygenase N terminus CarboxypepD_reg PF13620.6 EMD58793.1 - 3.5e-06 27.2 0.0 8.4e-06 26.0 0.0 1.7 1 1 0 1 1 1 1 Carboxypeptidase regulatory-like domain YtkA PF13115.6 EMD58793.1 - 0.014 16.0 0.0 0.034 14.7 0.0 1.7 1 0 0 1 1 1 0 YtkA-like PP2C_C PF07830.13 EMD58793.1 - 0.14 12.6 0.0 0.29 11.6 0.0 1.4 1 0 0 1 1 1 0 Protein serine/threonine phosphatase 2C, C-terminal domain SKIP_SNW PF02731.15 EMD58794.1 - 6.9e-69 230.6 2.9 6.9e-69 230.6 2.9 2.3 2 0 0 2 2 2 1 SKIP/SNW domain FAM60A PF15396.6 EMD58794.1 - 2.4 8.1 6.6 5.9 6.8 6.6 1.6 1 0 0 1 1 1 0 Protein Family FAM60A FAM75 PF14650.6 EMD58794.1 - 6.2 6.3 11.1 14 5.0 11.1 1.5 1 0 0 1 1 1 0 FAM75 family Peptidase_C48 PF02902.19 EMD58796.1 - 1.9e-07 31.2 0.3 3.1e-07 30.5 0.3 1.4 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain DUF4869 PF16163.5 EMD58797.1 - 0.0073 16.0 0.1 0.01 15.5 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4869) TAFII28 PF04719.14 EMD58798.1 - 3.2e-24 84.8 0.1 4e-23 81.3 0.1 2.2 1 1 0 1 1 1 1 hTAFII28-like protein conserved region Spt5_N PF11942.8 EMD58798.1 - 0.014 16.4 4.3 0.034 15.1 4.3 1.6 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal PGA2 PF07543.12 EMD58798.1 - 0.15 12.1 4.6 0.12 12.4 2.5 1.8 2 0 0 2 2 2 0 Protein trafficking PGA2 Ribosomal_L4 PF00573.22 EMD58799.1 - 4.4e-40 137.4 0.4 5.8e-40 137.0 0.4 1.2 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Ribos_L4_asso_C PF14374.6 EMD58799.1 - 2.2e-28 98.1 0.3 5.3e-28 96.9 0.3 1.7 1 0 0 1 1 1 1 60S ribosomal protein L4 C-terminal domain DSPc PF00782.20 EMD58800.1 - 2.4e-27 95.4 0.0 1.6e-24 86.2 0.0 2.3 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EMD58800.1 - 0.017 14.7 0.0 0.029 14.0 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase DUF3135 PF11333.8 EMD58800.1 - 0.12 12.6 0.0 0.31 11.3 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3135) DnaJ PF00226.31 EMD58801.1 - 1.1e-19 70.3 2.2 2.6e-19 69.1 2.2 1.7 1 0 0 1 1 1 1 DnaJ domain Metallophos PF00149.28 EMD58802.1 - 1.3e-13 51.9 0.0 2.1e-13 51.2 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EMD58802.1 - 0.00016 21.9 0.0 0.0011 19.2 0.0 2.0 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain DUF5004 PF16395.5 EMD58802.1 - 0.18 11.8 0.1 0.27 11.2 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5004) DUF3535 PF12054.8 EMD58804.1 - 1.5e-117 393.5 0.0 1.5e-116 390.2 0.0 2.6 3 0 0 3 3 3 1 Domain of unknown function (DUF3535) SNF2_N PF00176.23 EMD58804.1 - 1.5e-63 214.6 0.0 3.4e-63 213.5 0.0 1.5 1 1 1 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EMD58804.1 - 2.2e-20 73.1 0.0 2e-19 70.0 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HEAT PF02985.22 EMD58804.1 - 3.1e-13 48.7 17.8 0.014 15.6 0.3 9.3 9 0 0 9 9 9 4 HEAT repeat Vac14_Fab1_bd PF12755.7 EMD58804.1 - 1.2e-06 29.0 0.1 0.17 12.5 0.0 4.3 3 1 1 4 4 4 2 Vacuolar 14 Fab1-binding region HEAT_2 PF13646.6 EMD58804.1 - 3.1e-06 27.5 14.8 0.001 19.4 0.8 7.3 9 0 0 9 9 9 2 HEAT repeats CLASP_N PF12348.8 EMD58804.1 - 9.7e-05 22.0 0.1 0.0034 17.0 0.0 3.0 3 1 1 4 4 4 1 CLASP N terminal HEAT_EZ PF13513.6 EMD58804.1 - 0.0002 21.8 30.7 1.1 9.8 0.1 10.1 12 0 0 12 12 10 2 HEAT-like repeat TAF6_C PF07571.13 EMD58804.1 - 0.00079 19.7 0.1 4.4 7.7 0.0 4.8 5 0 0 5 5 5 1 TAF6 C-terminal HEAT repeat domain UME PF08064.13 EMD58804.1 - 0.0019 18.1 2.3 1.3 9.0 0.1 4.9 4 1 1 5 5 5 1 UME (NUC010) domain ResIII PF04851.15 EMD58804.1 - 0.029 14.4 0.0 0.09 12.8 0.0 1.9 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit IFRD PF05004.13 EMD58804.1 - 0.38 9.8 2.2 29 3.6 0.0 3.7 4 1 0 4 4 4 0 Interferon-related developmental regulator (IFRD) Peptidase_A4 PF01828.17 EMD58805.1 - 4.3e-40 137.4 6.0 5.5e-40 137.1 6.0 1.1 1 0 0 1 1 1 1 Peptidase A4 family Drf_FH1 PF06346.12 EMD58807.1 - 0.28 10.9 33.4 0.38 10.5 33.4 1.3 1 0 0 1 1 1 0 Formin Homology Region 1 But2 PF09792.9 EMD58808.1 - 3.8e-28 98.7 0.0 4.5e-28 98.4 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin 3 binding protein But2 C-terminal domain tRNA-synt_1 PF00133.22 EMD58809.1 - 1.2e-223 743.8 0.1 5.2e-223 741.7 0.0 1.9 2 0 0 2 2 2 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 EMD58809.1 - 2.2e-25 89.4 0.0 5.3e-25 88.1 0.0 1.6 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 EMD58809.1 - 1.6e-14 53.5 0.2 4.2e-05 22.5 0.0 4.2 4 1 0 4 4 4 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 EMD58809.1 - 0.1 11.9 0.1 0.29 10.4 0.0 1.8 2 0 0 2 2 2 0 tRNA synthetases class I (C) catalytic domain CX9C PF16860.5 EMD58810.1 - 0.0015 18.5 1.1 0.002 18.1 1.1 1.3 1 0 0 1 1 1 1 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, NDUF_B7 PF05676.13 EMD58810.1 - 0.014 15.1 1.6 1.1 9.0 0.1 2.1 1 1 1 2 2 2 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) CHCH PF06747.13 EMD58810.1 - 0.026 14.7 3.8 0.71 10.1 3.8 2.2 1 1 0 1 1 1 0 CHCH domain Cmc1 PF08583.10 EMD58810.1 - 0.034 14.1 3.3 0.065 13.3 2.7 1.7 1 1 1 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like Sfi1 PF08457.10 EMD58811.1 - 2.2e-181 604.3 106.6 2.4e-181 604.2 93.4 2.1 1 1 1 2 2 2 2 Sfi1 spindle body protein Tannase PF07519.11 EMD58812.1 - 7.2e-105 351.6 0.3 8.4e-105 351.4 0.3 1.0 1 0 0 1 1 1 1 Tannase and feruloyl esterase Peptidase_S9 PF00326.21 EMD58812.1 - 3e-05 23.6 0.3 0.18 11.2 0.1 2.4 2 0 0 2 2 2 2 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 EMD58812.1 - 0.028 13.7 0.0 0.069 12.4 0.0 1.6 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EMD58812.1 - 0.088 12.4 0.0 0.31 10.7 0.0 1.9 2 0 0 2 2 2 0 alpha/beta hydrolase fold DUF1201 PF06716.11 EMD58814.1 - 0.71 9.9 5.4 9.7 6.3 0.2 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1201) Amidase PF01425.21 EMD58815.1 - 1.1e-92 311.3 0.5 1.4e-92 311.0 0.5 1.1 1 0 0 1 1 1 1 Amidase Egh16-like PF11327.8 EMD58816.1 - 6.8e-58 196.1 13.9 9.9e-58 195.6 13.9 1.2 1 0 0 1 1 1 1 Egh16-like virulence factor ADH_N PF08240.12 EMD58817.1 - 5.6e-26 90.6 1.7 1.3e-25 89.4 1.7 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EMD58817.1 - 3.5e-20 72.3 0.4 6.3e-20 71.5 0.4 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EMD58817.1 - 0.00021 20.9 0.0 0.00078 19.0 0.0 1.9 2 1 0 2 2 2 1 Glucose dehydrogenase C-terminus AlaDh_PNT_C PF01262.21 EMD58817.1 - 0.00033 20.0 1.8 0.00059 19.2 1.8 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Sacchrp_dh_NADP PF03435.18 EMD58817.1 - 0.00063 20.0 0.1 0.0011 19.2 0.1 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Pep_deformylase PF01327.21 EMD58817.1 - 0.05 13.2 0.0 0.22 11.1 0.0 1.9 2 0 0 2 2 2 0 Polypeptide deformylase UDPG_MGDP_dh_N PF03721.14 EMD58817.1 - 0.052 13.1 0.1 0.092 12.3 0.1 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain ADH_zinc_N_2 PF13602.6 EMD58817.1 - 0.093 13.8 0.0 0.21 12.7 0.0 1.6 1 0 0 1 1 1 0 Zinc-binding dehydrogenase AhpC-TSA_2 PF13911.6 EMD58818.1 - 1.2e-22 80.1 0.0 2e-22 79.4 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme DUF3892 PF13031.6 EMD58818.1 - 0.15 12.7 0.0 0.29 11.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3892) AhpC-TSA PF00578.21 EMD58818.1 - 0.18 11.7 0.0 0.63 10.0 0.0 1.8 1 1 0 1 1 1 0 AhpC/TSA family SET PF00856.28 EMD58819.1 - 1.7e-12 48.0 0.1 4.1e-12 46.8 0.1 1.6 1 1 0 1 1 1 1 SET domain Dot_icm_IcmQ PF09475.10 EMD58819.1 - 0.076 12.5 0.0 0.17 11.4 0.0 1.6 1 0 0 1 1 1 0 Dot/Icm secretion system protein (dot_icm_IcmQ) Abhydrolase_6 PF12697.7 EMD58820.1 - 5.2e-12 46.9 9.2 5.5e-11 43.5 9.2 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family adh_short_C2 PF13561.6 EMD58821.1 - 6.4e-38 130.6 0.1 1.3e-37 129.6 0.1 1.4 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EMD58821.1 - 1e-32 113.2 0.6 1.6e-32 112.6 0.6 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EMD58821.1 - 3.9e-06 26.9 1.0 1e-05 25.5 0.9 1.8 1 1 0 1 1 1 1 KR domain Glu_dehyd_C PF16912.5 EMD58821.1 - 0.0001 21.9 0.3 0.00016 21.2 0.3 1.2 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N PF00107.26 EMD58821.1 - 0.084 12.9 0.4 0.15 12.1 0.4 1.4 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Pyr_redox PF00070.27 EMD58821.1 - 0.087 13.4 1.2 0.25 11.9 1.2 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 EMD58821.1 - 0.098 12.5 0.6 0.16 11.8 0.6 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain VD10_N PF08476.10 EMD58822.1 - 0.17 11.6 0.2 3.7 7.3 0.0 2.5 2 0 0 2 2 2 0 Viral D10 N-terminal GST_N_2 PF13409.6 EMD58825.1 - 1.3e-07 31.8 0.0 2.1e-07 31.1 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EMD58825.1 - 8.8e-07 29.3 0.2 2.2e-06 28.0 0.2 1.6 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EMD58825.1 - 9.1e-06 25.6 0.1 1.9e-05 24.6 0.1 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EMD58825.1 - 0.0033 17.6 0.0 0.0054 16.9 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_5 PF16865.5 EMD58825.1 - 0.038 14.6 0.0 0.066 13.8 0.0 1.3 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EMD58825.1 - 0.05 13.8 0.0 0.11 12.8 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Ldh_1_N PF00056.23 EMD58826.1 - 3.8e-33 114.6 0.1 6.1e-33 113.9 0.1 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 EMD58826.1 - 2.3e-21 76.4 0.0 3.2e-21 76.0 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain F420_oxidored PF03807.17 EMD58826.1 - 0.0002 21.9 0.2 0.00071 20.1 0.2 2.0 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent ApbA PF02558.16 EMD58826.1 - 0.00048 19.8 0.1 0.0034 17.0 0.1 2.1 1 1 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Sacchrp_dh_NADP PF03435.18 EMD58826.1 - 0.0066 16.7 0.3 0.069 13.4 0.1 2.3 2 1 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain Sar8_2 PF03058.14 EMD58826.1 - 0.087 13.4 0.3 0.19 12.3 0.3 1.5 1 0 0 1 1 1 0 Sar8.2 family DAO PF01266.24 EMD58826.1 - 0.096 12.2 2.6 0.37 10.3 0.5 2.2 1 1 1 2 2 2 0 FAD dependent oxidoreductase TrkA_N PF02254.18 EMD58826.1 - 0.14 12.5 1.2 0.18 12.1 0.2 1.7 2 0 0 2 2 2 0 TrkA-N domain zf-C3HC4_3 PF13920.6 EMD58827.1 - 1.1e-09 38.0 7.2 2e-09 37.2 7.2 1.5 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EMD58827.1 - 5.4e-08 32.7 7.3 8.6e-08 32.0 7.3 1.3 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EMD58827.1 - 2.5e-07 30.4 8.3 2.3e-06 27.4 8.3 2.1 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 EMD58827.1 - 3.4e-07 30.5 7.1 6.1e-07 29.7 7.1 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 EMD58827.1 - 6.1e-07 29.2 7.5 1.1e-06 28.4 7.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EMD58827.1 - 8.1e-06 25.8 4.6 9.2e-06 25.6 2.0 2.2 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EMD58827.1 - 3.4e-05 23.6 11.7 0.00095 19.0 12.0 2.2 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EMD58827.1 - 0.0095 16.1 5.2 0.053 13.7 5.6 2.0 1 1 1 2 2 2 1 zinc finger of C3HC4-type, RING NPR3 PF03666.13 EMD58827.1 - 0.0097 14.7 0.7 0.013 14.3 0.7 1.1 1 0 0 1 1 1 1 Nitrogen Permease regulator of amino acid transport activity 3 zf-rbx1 PF12678.7 EMD58827.1 - 0.077 13.3 4.8 0.17 12.2 4.8 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_4 PF14570.6 EMD58827.1 - 0.11 12.3 4.2 0.28 11.0 4.2 1.7 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain Zn_Tnp_IS91 PF14319.6 EMD58827.1 - 7.8 6.6 7.8 2.8 8.0 1.6 2.2 1 1 1 2 2 2 0 Transposase zinc-binding domain DNApol_Exo PF18136.1 EMD58828.1 - 2.9e-103 344.9 0.0 4.9e-103 344.2 0.0 1.3 1 0 0 1 1 1 1 DNA mitochondrial polymerase exonuclease domain DNA_pol_A PF00476.20 EMD58828.1 - 3.8e-57 194.1 0.0 5.9e-57 193.4 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase family A DNA_pol_B_2 PF03175.13 EMD58828.1 - 0.023 13.6 0.0 0.04 12.8 0.0 1.3 1 0 0 1 1 1 0 DNA polymerase type B, organellar and viral DNA_pol_A_exo1 PF01612.20 EMD58828.1 - 0.03 14.0 0.0 0.34 10.6 0.0 2.2 2 0 0 2 2 2 0 3'-5' exonuclease DUF2723 PF11028.8 EMD58829.1 - 0.077 12.9 1.0 0.09 12.7 1.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2723) TRAM_LAG1_CLN8 PF03798.16 EMD58830.1 - 3e-37 128.3 20.9 3e-37 128.3 20.9 1.6 2 0 0 2 2 2 1 TLC domain TRAM1 PF08390.11 EMD58830.1 - 2.8e-20 71.7 0.0 6.7e-20 70.5 0.0 1.7 1 0 0 1 1 1 1 TRAM1-like protein ATP-synt_E PF05680.12 EMD58830.1 - 0.1 12.9 0.0 0.19 12.1 0.0 1.4 1 0 0 1 1 1 0 ATP synthase E chain CrgA PF06781.12 EMD58830.1 - 0.14 12.3 0.5 2.3 8.3 0.0 2.9 2 0 0 2 2 2 0 Cell division protein CrgA Atg14 PF10186.9 EMD58831.1 - 2.4e-17 63.0 3.9 6e-17 61.7 3.9 1.5 1 1 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 VPS38 PF17649.1 EMD58831.1 - 5.8e-17 61.7 0.0 8e-08 31.6 0.0 3.1 3 0 0 3 3 3 3 Vacuolar protein sorting 38 GBP_C PF02841.14 EMD58831.1 - 1.3 8.4 7.5 1.9 7.8 7.5 1.1 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain DUF724 PF05266.14 EMD58831.1 - 1.4 8.7 5.2 2.6 7.9 5.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF724) CENP-H PF05837.12 EMD58831.1 - 3.4 8.1 8.4 6.5 7.2 8.4 1.4 1 0 0 1 1 1 0 Centromere protein H (CENP-H) YabA PF06156.13 EMD58831.1 - 6.6 7.4 5.4 12 6.5 5.4 1.5 1 0 0 1 1 1 0 Initiation control protein YabA Mhr1 PF12829.7 EMD58832.1 - 3.7e-31 107.0 0.0 9.2e-31 105.8 0.0 1.7 1 0 0 1 1 1 1 Transcriptional regulation of mitochondrial recombination IFN-gamma PF00714.17 EMD58832.1 - 0.029 14.2 0.9 0.058 13.2 0.1 1.8 2 0 0 2 2 2 0 Interferon gamma FemAB PF02388.16 EMD58832.1 - 0.45 9.3 8.1 0.18 10.6 0.7 2.6 3 0 0 3 3 3 0 FemAB family GFA PF04828.14 EMD58833.1 - 2.2e-16 60.0 0.1 3.8e-16 59.2 0.1 1.4 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme IATP PF04568.12 EMD58833.1 - 0.11 12.9 2.6 0.18 12.3 2.6 1.3 1 0 0 1 1 1 0 Mitochondrial ATPase inhibitor, IATP DUF4246 PF14033.6 EMD58834.1 - 2e-171 571.1 0.0 2.3e-171 570.9 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF4246) Aldolase_II PF00596.21 EMD58836.1 - 4.3e-47 160.5 0.8 5.9e-47 160.0 0.8 1.2 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain MFS_1 PF07690.16 EMD58837.1 - 1.5e-36 126.0 60.1 9.4e-35 120.2 60.1 2.5 2 1 0 2 2 2 2 Major Facilitator Superfamily Fungal_trans_2 PF11951.8 EMD58838.1 - 5.2e-35 121.0 0.0 7.8e-35 120.4 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain DUF1993 PF09351.10 EMD58840.1 - 7.4e-49 166.0 0.0 8.4e-49 165.8 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1993) MatC_N PF07158.11 EMD58840.1 - 0.17 11.9 0.0 0.29 11.2 0.0 1.3 1 0 0 1 1 1 0 Dicarboxylate carrier protein MatC N-terminus SH3_10 PF17902.1 EMD58840.1 - 0.23 11.6 0.0 0.53 10.4 0.0 1.6 2 0 0 2 2 2 0 SH3 domain HATPase_c PF02518.26 EMD58841.1 - 7.9e-22 77.9 0.0 1.5e-21 77.0 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EMD58841.1 - 1.1e-21 77.1 0.1 2.2e-21 76.1 0.1 1.5 1 0 0 1 1 1 1 Response regulator receiver domain PAS_4 PF08448.10 EMD58841.1 - 1.4e-08 34.9 0.0 5.9e-07 29.7 0.0 2.8 2 1 1 3 3 3 1 PAS fold HisKA PF00512.25 EMD58841.1 - 2.1e-06 27.7 2.0 1.1e-05 25.4 0.0 2.8 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain PAS_8 PF13188.7 EMD58841.1 - 3.6e-05 23.7 0.0 0.00012 22.0 0.0 1.9 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 EMD58841.1 - 0.00027 20.9 0.0 0.0007 19.6 0.0 1.8 1 0 0 1 1 1 1 PAS fold PAS_9 PF13426.7 EMD58841.1 - 0.0017 18.6 0.0 0.0051 17.0 0.0 1.9 1 0 0 1 1 1 1 PAS domain PAS_7 PF12860.7 EMD58841.1 - 0.0047 17.1 0.0 0.022 14.9 0.0 2.1 2 0 0 2 2 2 1 PAS fold Hemerythrin PF01814.23 EMD58842.1 - 6.2e-11 43.0 2.8 9.5e-11 42.4 2.8 1.3 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain Piwi PF02171.17 EMD58843.1 - 8.5e-69 232.1 0.1 1.2e-68 231.6 0.1 1.2 1 0 0 1 1 1 1 Piwi domain ArgoN PF16486.5 EMD58844.1 - 1.7e-06 28.7 0.0 3.7e-06 27.6 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of argonaute ArgoL1 PF08699.10 EMD58844.1 - 2.1e-05 24.1 0.1 4.4e-05 23.1 0.1 1.6 1 0 0 1 1 1 1 Argonaute linker 1 domain Gluconate_2-dh3 PF13618.6 EMD58844.1 - 0.0013 19.0 0.1 0.0028 17.9 0.1 1.5 1 0 0 1 1 1 1 Gluconate 2-dehydrogenase subunit 3 Pneumovirus_M2 PF06436.11 EMD58844.1 - 0.05 13.1 0.3 3.9 6.9 0.0 2.7 2 1 0 2 2 2 0 Pneumovirus matrix protein 2 (M2) Spb1_C PF07780.12 EMD58845.1 - 3.5e-84 281.7 23.9 3.5e-84 281.7 23.9 3.1 3 1 0 3 3 3 1 Spb1 C-terminal domain FtsJ PF01728.19 EMD58845.1 - 6.1e-55 186.1 0.1 1.1e-54 185.2 0.1 1.5 1 0 0 1 1 1 1 FtsJ-like methyltransferase DUF3381 PF11861.8 EMD58845.1 - 1e-52 178.3 13.4 1e-52 178.3 13.4 4.9 5 1 0 5 5 5 1 Domain of unknown function (DUF3381) Rep_fac-A_3 PF08661.11 EMD58847.1 - 1.5e-26 92.7 0.0 1.7e-26 92.6 0.0 1.0 1 0 0 1 1 1 1 Replication factor A protein 3 BRCT PF00533.26 EMD58848.1 - 4.7e-06 26.9 0.2 0.00016 22.0 0.0 2.8 2 1 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EMD58848.1 - 0.0019 18.6 0.0 0.0045 17.4 0.0 1.6 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain PTCB-BRCT PF12738.7 EMD58848.1 - 0.038 14.0 0.0 0.092 12.7 0.0 1.7 1 0 0 1 1 1 0 twin BRCT domain STE2 PF02116.15 EMD58849.1 - 5.7e-84 281.7 17.4 6.7e-84 281.5 17.4 1.0 1 0 0 1 1 1 1 Fungal pheromone mating factor STE2 GPCR HET PF06985.11 EMD58850.1 - 5e-12 46.4 9.3 1.1e-09 38.7 2.4 3.4 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) Hemerythrin PF01814.23 EMD58851.1 - 3.1e-07 31.1 0.0 4.2e-07 30.6 0.0 1.2 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain Presenilin PF01080.17 EMD58852.1 - 1.6 7.4 7.3 0.28 9.9 2.2 2.1 2 0 0 2 2 2 0 Presenilin Ribosomal_L5e PF17144.4 EMD58853.1 - 9.9e-80 266.3 0.4 1.6e-79 265.6 0.4 1.3 1 0 0 1 1 1 1 Ribosomal large subunit proteins 60S L5, and 50S L18 Ribosomal_L18_c PF14204.6 EMD58853.1 - 1.3e-36 125.4 7.3 1.3e-36 125.4 7.3 2.0 2 0 0 2 2 2 1 Ribosomal L18 C-terminal region Actin PF00022.19 EMD58854.1 - 7.7e-113 377.2 0.0 5.4e-112 374.4 0.0 1.8 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EMD58854.1 - 0.037 12.8 0.0 0.23 10.3 0.0 2.2 1 1 0 1 1 1 0 MreB/Mbl protein Actin_micro PF17003.5 EMD58854.1 - 0.22 10.7 0.2 0.67 9.1 0.1 1.8 2 0 0 2 2 2 0 Putative actin-like family DUF1724 PF08350.10 EMD58856.1 - 0.15 12.2 0.0 1.3 9.2 0.0 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF1724) Egh16-like PF11327.8 EMD58859.1 - 7.6e-69 231.8 12.8 9.3e-69 231.5 12.8 1.1 1 0 0 1 1 1 1 Egh16-like virulence factor Pmp3 PF01679.17 EMD58860.1 - 9.9e-18 64.1 4.6 2e-17 63.1 4.6 1.5 1 0 0 1 1 1 1 Proteolipid membrane potential modulator CNOT11 PF10155.9 EMD58860.1 - 4.2e-05 23.7 0.0 8.5e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 11 CsbD PF05532.12 EMD58861.1 - 1.6e-16 59.9 26.3 7.1e-10 38.7 7.8 3.2 2 1 1 3 3 3 3 CsbD-like IDO PF01231.18 EMD58862.1 - 1.3e-165 551.5 0.0 1.5e-165 551.3 0.0 1.0 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase MMR_HSR1_C PF08438.10 EMD58863.1 - 1.2e-36 125.6 0.0 2.3e-36 124.8 0.0 1.5 1 0 0 1 1 1 1 GTPase of unknown function C-terminal MMR_HSR1 PF01926.23 EMD58863.1 - 4.7e-20 71.8 0.0 1.4e-19 70.3 0.0 1.8 1 1 1 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EMD58863.1 - 1e-08 34.8 0.1 1.9e-07 30.7 0.0 2.3 2 0 0 2 2 2 1 Ferrous iron transport protein B GTP_EFTU PF00009.27 EMD58863.1 - 0.0022 17.6 0.1 0.4 10.2 0.0 2.5 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EMD58863.1 - 0.0053 16.7 0.8 0.17 11.8 0.1 2.3 2 0 0 2 2 2 1 RsgA GTPase ABC_tran PF00005.27 EMD58863.1 - 0.023 15.2 0.0 0.73 10.3 0.0 2.2 2 0 0 2 2 2 0 ABC transporter ATP_bind_1 PF03029.17 EMD58863.1 - 0.063 13.0 0.2 13 5.5 0.0 2.2 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein Dynamin_N PF00350.23 EMD58863.1 - 0.064 13.3 0.8 0.14 12.2 0.2 1.9 2 0 0 2 2 2 0 Dynamin family Ploopntkinase3 PF18751.1 EMD58863.1 - 0.069 13.1 0.0 0.23 11.3 0.0 1.8 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 KTI12 PF08433.10 EMD58863.1 - 0.11 12.0 0.0 0.25 10.7 0.0 1.6 1 0 0 1 1 1 0 Chromatin associated protein KTI12 MMR_HSR1_Xtn PF16897.5 EMD58863.1 - 0.17 12.0 0.1 0.33 11.0 0.1 1.4 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain AIG1 PF04548.16 EMD58863.1 - 0.22 10.8 0.4 1.1 8.6 0.2 2.0 2 0 0 2 2 2 0 AIG1 family Pkinase PF00069.25 EMD58864.1 - 2.5e-51 174.6 0.0 3.7e-51 174.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD58864.1 - 9.1e-18 64.5 0.3 1.8e-17 63.5 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 EMD58864.1 - 0.071 13.0 0.0 0.22 11.4 0.0 1.8 1 0 0 1 1 1 0 Phosphotransferase enzyme family SPT16 PF08644.11 EMD58864.1 - 0.15 12.2 0.1 0.31 11.2 0.1 1.5 1 0 0 1 1 1 0 FACT complex subunit (SPT16/CDC68) Pex24p PF06398.11 EMD58865.1 - 1.7e-90 303.6 0.1 2.1e-90 303.3 0.1 1.1 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin PRT_C PF08372.10 EMD58865.1 - 5.4 6.8 7.1 0.31 10.8 0.3 2.2 3 0 0 3 3 3 0 Plant phosphoribosyltransferase C-terminal Tubulin PF00091.25 EMD58866.1 - 1.4e-67 227.8 0.0 2.1e-67 227.2 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EMD58866.1 - 8.9e-46 155.1 0.7 2.8e-45 153.5 0.2 1.9 2 0 0 2 2 2 1 Tubulin C-terminal domain GDPD PF03009.17 EMD58866.1 - 9.9e-33 114.0 0.0 2.3e-32 112.7 0.0 1.7 1 1 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family Misat_Tub_SegII PF10644.9 EMD58866.1 - 2e-06 28.1 0.0 3.9e-06 27.1 0.0 1.5 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain GDPD_2 PF13653.6 EMD58866.1 - 0.00053 20.4 0.2 0.0021 18.5 0.1 2.1 2 0 0 2 2 2 1 Glycerophosphoryl diester phosphodiesterase family Tubulin_3 PF14881.6 EMD58866.1 - 0.019 14.6 0.0 0.055 13.2 0.0 1.7 2 0 0 2 2 2 0 Tubulin domain Coatomer_E PF04733.14 EMD58867.1 - 7.3e-58 196.3 7.6 9.1e-58 196.0 7.6 1.0 1 0 0 1 1 1 1 Coatomer epsilon subunit TPR_14 PF13428.6 EMD58867.1 - 2.2e-05 24.9 7.3 0.29 12.1 0.0 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 EMD58867.1 - 0.00013 22.5 6.7 0.082 13.6 0.1 3.7 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 EMD58867.1 - 0.00023 21.0 10.4 0.028 14.5 0.0 5.2 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_19 PF14559.6 EMD58867.1 - 0.00043 20.7 13.5 0.014 15.9 2.8 3.6 3 2 2 5 5 5 4 Tetratricopeptide repeat ANAPC3 PF12895.7 EMD58867.1 - 0.00089 19.4 0.3 0.73 10.1 0.0 3.5 3 1 0 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.28 EMD58867.1 - 0.0019 18.0 0.3 0.2 11.6 0.0 3.6 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_8 PF13181.6 EMD58867.1 - 0.0085 16.2 1.9 3.7 8.0 0.0 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.6 EMD58867.1 - 0.0085 15.8 0.5 0.32 10.7 0.0 3.2 3 0 0 3 3 3 1 TPR repeat TPR_12 PF13424.6 EMD58867.1 - 0.019 15.2 12.6 0.17 12.2 0.1 4.4 3 2 1 4 4 4 0 Tetratricopeptide repeat TPR_4 PF07721.14 EMD58867.1 - 0.022 15.4 8.8 0.053 14.2 0.7 3.6 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_10 PF13374.6 EMD58867.1 - 0.15 12.0 1.8 2.9 7.9 0.1 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 EMD58867.1 - 1.9 9.3 5.1 44 5.0 0.0 4.5 5 0 0 5 5 4 0 Tetratricopeptide repeat Methyltransf_25 PF13649.6 EMD58868.1 - 5.9e-08 33.3 0.0 1.1e-07 32.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMD58868.1 - 1.1e-05 26.0 0.0 2.6e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMD58868.1 - 0.016 15.0 2.1 0.059 13.2 2.1 1.9 1 1 0 1 1 1 0 Methyltransferase domain Spermine_synth PF01564.17 EMD58869.1 - 6e-71 237.7 0.0 1.1e-70 236.8 0.0 1.4 2 0 0 2 2 2 1 Spermine/spermidine synthase domain Spermine_synt_N PF17284.2 EMD58869.1 - 6e-25 86.9 0.2 1e-24 86.2 0.2 1.4 1 0 0 1 1 1 1 Spermidine synthase tetramerisation domain Methyltransf_25 PF13649.6 EMD58869.1 - 0.00052 20.7 0.0 0.001 19.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMD58869.1 - 0.0048 17.6 0.2 0.035 14.8 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.7 EMD58869.1 - 0.074 13.0 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain NAD_kinase PF01513.21 EMD58870.1 - 2.2e-79 266.7 0.0 3.2e-79 266.2 0.0 1.3 1 0 0 1 1 1 1 ATP-NAD kinase PEP_mutase PF13714.6 EMD58871.1 - 9.8e-46 156.1 0.4 1.1e-45 155.9 0.4 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase ICL PF00463.21 EMD58871.1 - 1.2e-20 73.5 0.1 1.6e-20 73.1 0.1 1.1 1 0 0 1 1 1 1 Isocitrate lyase family Pantoate_transf PF02548.15 EMD58871.1 - 0.006 16.0 0.1 0.011 15.2 0.1 1.5 1 0 0 1 1 1 1 Ketopantoate hydroxymethyltransferase Zn_clus PF00172.18 EMD58872.1 - 0.00018 21.6 8.3 0.00038 20.5 0.9 2.4 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SAPS PF04499.15 EMD58872.1 - 0.0017 17.2 6.6 0.0026 16.6 6.6 1.2 1 0 0 1 1 1 1 SIT4 phosphatase-associated protein DDHD PF02862.17 EMD58872.1 - 0.0027 17.9 10.7 0.0053 16.9 10.7 1.4 1 0 0 1 1 1 1 DDHD domain Rrn6 PF10214.9 EMD58872.1 - 0.0055 15.3 22.6 0.0095 14.5 22.6 1.4 1 0 0 1 1 1 1 RNA polymerase I-specific transcription-initiation factor CCSAP PF15748.5 EMD58872.1 - 0.012 15.9 22.1 0.024 14.8 22.1 1.4 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated SID-1_RNA_chan PF13965.6 EMD58872.1 - 0.018 13.5 2.6 0.024 13.1 2.6 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 EPL1 PF10513.9 EMD58872.1 - 0.029 14.7 18.4 0.054 13.9 18.4 1.4 1 0 0 1 1 1 0 Enhancer of polycomb-like Velvet PF11754.8 EMD58872.1 - 0.099 12.6 19.1 0.042 13.8 15.2 2.0 2 0 0 2 2 2 0 Velvet factor Paf1 PF03985.13 EMD58872.1 - 0.18 10.8 23.1 0.29 10.1 23.1 1.2 1 0 0 1 1 1 0 Paf1 Membralin PF09746.9 EMD58872.1 - 0.29 10.1 11.9 0.46 9.5 11.9 1.2 1 0 0 1 1 1 0 Tumour-associated protein eIF-3_zeta PF05091.12 EMD58872.1 - 0.32 9.9 29.1 0.48 9.3 29.1 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) TFIIA PF03153.13 EMD58872.1 - 0.37 10.7 54.3 0.78 9.7 54.3 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit GPCR_chapero_1 PF11904.8 EMD58872.1 - 0.69 9.3 12.1 1.4 8.3 12.1 1.4 1 0 0 1 1 1 0 GPCR-chaperone Gti1_Pac2 PF09729.9 EMD58872.1 - 0.9 9.6 17.0 1.6 8.8 17.0 1.4 1 0 0 1 1 1 0 Gti1/Pac2 family Endostatin PF06482.11 EMD58872.1 - 0.97 8.8 20.9 1.7 8.1 20.9 1.3 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin SLC12 PF03522.15 EMD58872.1 - 1.6 7.7 22.3 2.4 7.1 22.3 1.2 1 0 0 1 1 1 0 Solute carrier family 12 GREB1 PF15782.5 EMD58872.1 - 3.9 4.5 23.1 5.4 4.0 23.1 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer AAA_23 PF13476.6 EMD58872.1 - 4.4 7.7 26.4 7.5 7.0 26.4 1.3 1 0 0 1 1 1 0 AAA domain Pex14_N PF04695.13 EMD58872.1 - 4.7 7.9 39.3 0.13 12.9 31.9 2.2 2 0 0 2 2 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF2828 PF11443.8 EMD58872.1 - 5.3 5.0 21.4 7.7 4.5 21.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Hid1 PF12722.7 EMD58872.1 - 5.4 5.0 21.2 8.1 4.4 21.2 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein ALMT PF11744.8 EMD58872.1 - 6.5 5.5 20.5 10 4.8 20.5 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Pal1 PF08316.11 EMD58872.1 - 6.6 7.5 12.9 17 6.2 12.9 1.7 1 0 0 1 1 1 0 Pal1 cell morphology protein NPR3 PF03666.13 EMD58872.1 - 7.3 5.3 20.7 13 4.5 20.7 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 LMBR1 PF04791.16 EMD58872.1 - 8.1 5.2 12.6 16 4.3 12.6 1.4 1 0 0 1 1 1 0 LMBR1-like membrane protein EOS1 PF12326.8 EMD58872.1 - 9 6.2 11.2 25 4.8 11.2 1.8 1 0 0 1 1 1 0 N-glycosylation protein VIT1 PF01988.19 EMD58872.1 - 9.1 6.1 14.6 17 5.2 14.6 1.4 1 0 0 1 1 1 0 VIT family SpoIIP PF07454.11 EMD58872.1 - 9.4 5.6 24.7 15 5.0 24.7 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) T3SchapCesA PF11439.8 EMD58873.1 - 0.0028 17.7 1.3 0.0028 17.7 1.3 2.7 2 1 0 2 2 2 1 Type III secretion system filament chaperone CesA ATG16 PF08614.11 EMD58873.1 - 2.4 8.4 53.3 1.6 8.9 5.2 4.5 1 1 3 4 4 4 0 Autophagy protein 16 (ATG16) YscO PF07321.12 EMD58873.1 - 3.6 7.5 39.8 0.097 12.6 16.5 4.4 2 1 1 4 4 4 0 Type III secretion protein YscO bZIP_2 PF07716.15 EMD58873.1 - 4 7.6 21.1 0.85 9.8 0.9 5.2 5 0 0 5 5 5 0 Basic region leucine zipper bZIP_1 PF00170.21 EMD58873.1 - 6.6 6.9 20.7 1.6 8.9 0.9 5.3 3 1 2 5 5 5 0 bZIP transcription factor HTH_Tnp_Tc3_2 PF01498.18 EMD58874.1 - 1e-17 64.1 0.3 1.8e-17 63.3 0.3 1.4 1 0 0 1 1 1 1 Transposase HTH_32 PF13565.6 EMD58874.1 - 1.8e-06 28.4 0.1 1.8e-06 28.4 0.1 2.5 2 1 1 3 3 3 1 Homeodomain-like domain HTH_23 PF13384.6 EMD58874.1 - 2.5e-06 27.1 0.1 0.00061 19.5 0.0 2.3 2 0 0 2 2 2 2 Homeodomain-like domain HTH_33 PF13592.6 EMD58874.1 - 2.9e-05 23.6 0.2 6.7e-05 22.4 0.2 1.5 1 0 0 1 1 1 1 Winged helix-turn helix HTH_Tnp_ISL3 PF13542.6 EMD58874.1 - 0.00037 19.8 0.6 0.71 9.3 0.0 2.9 3 0 0 3 3 3 2 Helix-turn-helix domain of transposase family ISL3 HTH_21 PF13276.6 EMD58874.1 - 0.0053 16.9 0.2 0.018 15.2 0.1 1.8 2 0 0 2 2 2 1 HTH-like domain DDE_Tnp_ISAZ013 PF07592.11 EMD58874.1 - 0.0077 15.2 0.0 0.011 14.7 0.0 1.3 1 1 0 1 1 1 1 Rhodopirellula transposase DDE domain HTH_29 PF13551.6 EMD58874.1 - 0.035 14.1 0.0 0.094 12.7 0.0 1.8 2 0 0 2 2 2 0 Winged helix-turn helix Sigma70_r4_2 PF08281.12 EMD58874.1 - 0.083 12.6 0.1 0.17 11.6 0.0 1.6 2 0 0 2 2 2 0 Sigma-70, region 4 G-alpha PF00503.20 EMD58876.1 - 2.6e-107 359.0 1.5 3.1e-107 358.8 1.5 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EMD58876.1 - 1e-13 51.1 0.7 6.8e-09 35.4 0.1 2.5 2 0 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EMD58876.1 - 5.3e-05 22.7 3.8 0.00068 19.1 0.1 2.6 3 0 0 3 3 3 2 Gtr1/RagA G protein conserved region DUF5390 PF17365.2 EMD58876.1 - 0.028 14.7 0.9 0.11 12.8 0.1 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5390) DUF2985 PF11204.8 EMD58876.1 - 0.083 13.1 0.0 0.22 11.7 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2985) Roc PF08477.13 EMD58876.1 - 0.09 13.0 0.4 3.2 8.0 0.0 2.7 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase FtsK_SpoIIIE PF01580.18 EMD58876.1 - 0.094 12.0 0.0 0.24 10.7 0.0 1.6 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_29 PF13555.6 EMD58876.1 - 0.12 12.1 0.2 0.52 10.1 0.1 2.0 1 1 1 2 2 2 0 P-loop containing region of AAA domain DUF1713 PF08213.11 EMD58877.1 - 2.2e-11 43.4 22.0 5e-11 42.3 22.0 1.6 1 0 0 1 1 1 1 Mitochondrial domain of unknown function (DUF1713) Tis11B_N PF04553.12 EMD58877.1 - 0.13 12.9 2.2 0.2 12.2 1.2 1.9 2 0 0 2 2 2 0 Tis11B like protein, N terminus Med15 PF09606.10 EMD58878.1 - 0.53 8.9 29.1 0.63 8.7 29.1 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Macoilin PF09726.9 EMD58878.1 - 0.71 8.4 10.6 0.87 8.1 10.6 1.1 1 0 0 1 1 1 0 Macoilin family SOG2 PF10428.9 EMD58878.1 - 0.85 8.7 5.9 0.99 8.5 5.9 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein Hexapep PF00132.24 EMD58880.1 - 1.1e-13 50.3 12.3 4.6e-07 29.3 2.8 5.1 4 1 1 5 5 5 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 EMD58880.1 - 1.2e-07 31.3 11.9 0.0013 18.5 0.0 4.0 4 1 0 4 4 4 2 Hexapeptide repeat of succinyl-transferase Fucokinase PF07959.12 EMD58880.1 - 0.0069 15.4 0.3 0.0082 15.1 0.3 1.1 1 0 0 1 1 1 1 L-fucokinase HET-S PF17108.5 EMD58880.1 - 0.14 11.9 0.6 0.45 10.3 0.6 1.9 1 0 0 1 1 1 0 N-terminal small S protein of HET, non-prionic Fungal_trans PF04082.18 EMD58881.1 - 6.2e-22 77.9 0.1 1.2e-21 77.0 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 EMD58881.1 - 3.4e-08 33.5 15.2 0.00042 20.6 2.5 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMD58881.1 - 2.7e-06 27.5 7.0 2.7e-06 27.5 7.0 2.6 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMD58881.1 - 4e-05 24.1 13.7 0.02 15.7 2.5 2.9 2 0 0 2 2 2 2 C2H2-type zinc finger DLIC PF05783.11 EMD58881.1 - 0.13 11.0 1.8 0.39 9.5 1.8 1.7 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) Maf1 PF09174.10 EMD58883.1 - 1.1e-50 172.2 0.0 1.5e-50 171.8 0.0 1.2 1 0 0 1 1 1 1 Maf1 regulator Clat_adaptor_s PF01217.20 EMD58884.1 - 6.6e-53 178.5 1.8 7.8e-53 178.2 1.8 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain PulA_N1 PF17999.1 EMD58884.1 - 0.061 14.1 0.0 0.11 13.3 0.0 1.4 1 0 0 1 1 1 0 Pullulanase N1-terminal domain Aldo_ket_red PF00248.21 EMD58885.1 - 4.2e-13 49.1 0.0 5.5e-13 48.8 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Imp-YgjV PF10688.9 EMD58887.1 - 0.072 12.9 1.3 0.41 10.4 0.1 2.1 2 0 0 2 2 2 0 Bacterial inner membrane protein Glyco_hydro_72 PF03198.14 EMD58889.1 - 6e-131 436.4 4.3 7.2e-131 436.1 4.3 1.0 1 0 0 1 1 1 1 Glucanosyltransferase Cellulase PF00150.18 EMD58889.1 - 8.7e-05 22.1 0.3 0.18 11.2 0.0 2.4 2 1 0 2 2 2 2 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_2_C PF02836.17 EMD58889.1 - 0.0012 18.1 0.3 0.0031 16.7 0.3 1.6 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Syntaxin PF00804.25 EMD58890.1 - 5.5e-23 81.7 6.6 5.5e-23 81.7 6.6 1.9 1 1 1 2 2 2 1 Syntaxin SNARE PF05739.19 EMD58890.1 - 7.9e-09 35.4 0.2 2e-08 34.1 0.2 1.8 1 0 0 1 1 1 1 SNARE domain DUF2721 PF11026.8 EMD58890.1 - 0.0009 19.1 1.9 0.0011 18.9 0.1 2.0 2 1 1 3 3 3 1 Protein of unknown function (DUF2721) Syntaxin_2 PF14523.6 EMD58890.1 - 0.014 15.7 6.4 0.014 15.7 6.4 2.3 2 0 0 2 2 2 0 Syntaxin-like protein TMEM156 PF15106.6 EMD58890.1 - 0.023 14.1 0.0 0.036 13.5 0.0 1.2 1 0 0 1 1 1 0 TMEM156 protein family Orf78 PF06024.12 EMD58890.1 - 0.041 14.2 0.2 0.041 14.2 0.2 1.8 2 0 0 2 2 2 0 Orf78 (ac78) T2SSF PF00482.23 EMD58890.1 - 0.043 13.8 0.6 0.24 11.3 0.2 2.1 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein F Synaptobrevin PF00957.21 EMD58890.1 - 0.049 13.4 1.7 0.14 11.9 1.7 1.8 1 0 0 1 1 1 0 Synaptobrevin DUF4094 PF13334.6 EMD58890.1 - 0.34 11.4 0.0 0.34 11.4 0.0 3.4 2 1 2 4 4 4 0 Domain of unknown function (DUF4094) DUF2207 PF09972.9 EMD58890.1 - 0.35 9.6 2.3 0.35 9.6 0.1 1.9 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) Cnn_1N PF07989.11 EMD58890.1 - 0.98 9.6 12.5 1.7 8.8 4.2 2.5 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 CCDC-167 PF15188.6 EMD58890.1 - 1.2 9.5 11.1 0.94 9.9 0.4 3.3 2 2 1 3 3 3 0 Coiled-coil domain-containing protein 167 LPP PF04728.13 EMD58890.1 - 2.4 8.6 9.6 19 5.8 3.1 3.7 3 2 0 3 3 3 0 Lipoprotein leucine-zipper Jnk-SapK_ap_N PF09744.9 EMD58890.1 - 2.8 8.1 13.2 0.79 9.9 4.1 2.3 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 Nup188_C PF18378.1 EMD58891.1 - 8.7e-143 475.6 1.2 1.5e-142 474.9 1.2 1.4 1 0 0 1 1 1 1 Nuclear pore protein NUP188 C-terminal domain Nup188 PF10487.9 EMD58891.1 - 4.8e-58 196.9 1.6 2.3e-52 178.1 0.3 2.9 2 1 0 2 2 2 2 Nucleoporin subcomplex protein binding to Pom34 IGPS PF00218.21 EMD58892.1 - 2.1e-96 322.0 0.1 6.9e-95 317.0 0.0 2.2 2 0 0 2 2 2 1 Indole-3-glycerol phosphate synthase PRAI PF00697.22 EMD58892.1 - 1e-48 165.7 0.8 4.9e-44 150.5 0.4 2.5 1 1 1 2 2 2 2 N-(5'phosphoribosyl)anthranilate (PRA) isomerase GATase PF00117.28 EMD58892.1 - 7.2e-47 159.6 0.1 2.4e-46 157.9 0.0 1.8 2 0 0 2 2 2 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 EMD58892.1 - 1.2e-05 25.1 0.1 4.2e-05 23.4 0.1 1.9 1 1 0 1 1 1 1 Peptidase C26 NanE PF04131.14 EMD58892.1 - 5.6e-05 22.4 0.3 0.015 14.5 0.0 2.5 2 0 0 2 2 2 2 Putative N-acetylmannosamine-6-phosphate epimerase QRPTase_C PF01729.19 EMD58892.1 - 0.0043 16.9 0.5 0.056 13.2 0.1 2.8 3 0 0 3 3 3 1 Quinolinate phosphoribosyl transferase, C-terminal domain BRCT PF00533.26 EMD58893.1 - 3.7e-07 30.4 0.0 6.9e-07 29.6 0.0 1.5 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EMD58893.1 - 2.3e-05 24.7 0.0 6.6e-05 23.2 0.0 1.8 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain PTCB-BRCT PF12738.7 EMD58893.1 - 0.00029 20.7 0.2 0.00072 19.5 0.1 1.8 2 0 0 2 2 2 1 twin BRCT domain RTT107_BRCT_5 PF16770.5 EMD58893.1 - 0.018 14.9 0.0 0.17 11.8 0.0 2.2 2 0 0 2 2 2 0 Regulator of Ty1 transposition protein 107 BRCT domain Rubella_E2 PF05749.11 EMD58893.1 - 0.11 11.9 0.2 0.21 11.0 0.2 1.4 1 0 0 1 1 1 0 Rubella membrane glycoprotein E2 DUF3446 PF11928.8 EMD58893.1 - 5.4 7.4 9.2 2.8 8.3 0.4 2.3 2 0 0 2 2 2 0 Early growth response N-terminal domain PGG PF13962.6 EMD58894.1 - 0.38 10.6 5.4 14 5.6 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function HhH-GPD PF00730.25 EMD58895.1 - 4.4e-20 72.1 0.0 9.7e-20 71.0 0.0 1.6 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 EMD58895.1 - 3.2e-07 29.9 0.0 8.8e-07 28.5 0.0 1.8 1 0 0 1 1 1 1 Helix-hairpin-helix motif MTHFR_C PF12225.8 EMD58895.1 - 0.26 11.0 1.0 2.9 7.6 0.4 2.2 2 0 0 2 2 2 0 Methylene-tetrahydrofolate reductase C terminal RSN1_7TM PF02714.15 EMD58896.1 - 8.7e-86 287.6 24.5 1.7e-85 286.7 24.5 1.5 1 0 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate PHM7_cyt PF14703.6 EMD58896.1 - 5.6e-27 95.1 1.4 6.9e-15 55.7 0.2 2.5 2 0 0 2 2 2 2 Cytosolic domain of 10TM putative phosphate transporter RSN1_TM PF13967.6 EMD58896.1 - 9.8e-20 70.9 2.8 9.8e-20 70.9 2.8 4.2 4 1 0 4 4 4 1 Late exocytosis, associated with Golgi transport PHM7_ext PF12621.8 EMD58896.1 - 1.5e-13 50.7 0.0 5.4e-13 48.9 0.0 2.0 1 0 0 1 1 1 1 Extracellular tail, of 10TM putative phosphate transporter V_ATPase_I PF01496.19 EMD58896.1 - 1.2 7.0 4.6 4.2 5.2 0.0 2.3 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family SRP-alpha_N PF04086.13 EMD58896.1 - 9.2 6.1 20.8 0.44 10.4 1.2 2.4 2 1 0 2 2 2 0 Signal recognition particle, alpha subunit, N-terminal DUF3987 PF13148.6 EMD58897.1 - 0.21 10.5 6.4 0.13 11.2 3.6 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3987) Ndc1_Nup PF09531.10 EMD58897.1 - 1.2 7.7 13.3 1.6 7.3 13.3 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Presenilin PF01080.17 EMD58897.1 - 1.6 7.4 4.4 2.1 7.0 4.4 1.1 1 0 0 1 1 1 0 Presenilin KAR9 PF08580.10 EMD58897.1 - 7.7 4.9 12.9 10 4.5 12.9 1.1 1 0 0 1 1 1 0 Yeast cortical protein KAR9 MAP65_ASE1 PF03999.12 EMD58897.1 - 8.2 5.0 16.5 11 4.6 16.5 1.1 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) ThiP_synth PF10120.9 EMD58898.1 - 0.048 13.3 0.0 0.07 12.7 0.0 1.2 1 0 0 1 1 1 0 Thiamine-phosphate synthase FTA4 PF13093.6 EMD58899.1 - 4.1e-50 170.5 6.5 4.9e-50 170.2 6.5 1.1 1 0 0 1 1 1 1 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 PCEMA1 PF07418.11 EMD58899.1 - 0.02 14.4 2.2 0.025 14.1 2.2 1.3 1 0 0 1 1 1 0 Acidic phosphoprotein precursor PCEMA1 p450 PF00067.22 EMD58900.1 - 2.1e-07 30.1 0.2 6.8e-07 28.4 0.2 1.6 1 1 0 1 1 1 1 Cytochrome P450 GerD PF17898.1 EMD58900.1 - 0.027 14.4 0.0 0.32 10.9 0.0 2.4 2 0 0 2 2 2 0 Spore germination GerD central core domain Cutinase PF01083.22 EMD58901.1 - 2.6e-36 125.2 0.0 3.2e-36 125.0 0.0 1.1 1 0 0 1 1 1 1 Cutinase PE-PPE PF08237.11 EMD58901.1 - 0.038 13.5 0.0 0.058 12.9 0.0 1.2 1 0 0 1 1 1 0 PE-PPE domain Abhydrolase_2 PF02230.16 EMD58901.1 - 0.038 13.8 0.0 0.052 13.4 0.0 1.2 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase DUF2974 PF11187.8 EMD58901.1 - 0.041 13.4 0.0 0.06 12.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Inhibitor_I53 PF11714.8 EMD58901.1 - 0.14 12.4 0.1 0.25 11.6 0.1 1.4 1 0 0 1 1 1 0 Thrombin inhibitor Madanin VirJ PF06057.11 EMD58901.1 - 0.15 11.9 0.0 0.2 11.5 0.0 1.2 1 0 0 1 1 1 0 Bacterial virulence protein (VirJ) LPD15 PF18828.1 EMD58901.1 - 0.2 11.6 0.0 0.33 10.9 0.0 1.3 1 0 0 1 1 1 0 Large polyvalent-protein-associated domain 15 Cutinase PF01083.22 EMD58902.1 - 4.4e-33 114.7 0.0 5.8e-33 114.3 0.0 1.1 1 0 0 1 1 1 1 Cutinase PE-PPE PF08237.11 EMD58902.1 - 0.00014 21.5 0.0 0.00021 20.9 0.0 1.3 1 0 0 1 1 1 1 PE-PPE domain VirJ PF06057.11 EMD58902.1 - 0.0031 17.4 0.0 0.0045 16.9 0.0 1.2 1 0 0 1 1 1 1 Bacterial virulence protein (VirJ) Palm_thioest PF02089.15 EMD58902.1 - 0.0091 15.9 0.0 0.01 15.7 0.0 1.1 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Abhydrolase_1 PF00561.20 EMD58902.1 - 0.021 14.5 0.0 0.027 14.1 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold Lipase_3 PF01764.25 EMD58902.1 - 0.13 12.2 0.0 0.17 11.7 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) DUF2974 PF11187.8 EMD58902.1 - 0.15 11.6 0.0 0.21 11.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) DUF676 PF05057.14 EMD58903.1 - 3.2e-54 183.7 0.0 5.3e-54 183.0 0.0 1.3 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_6 PF12697.7 EMD58903.1 - 0.00018 22.2 0.0 0.00027 21.6 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family PGAP1 PF07819.13 EMD58903.1 - 0.0014 18.4 0.0 0.0052 16.5 0.0 1.8 1 1 0 1 1 1 1 PGAP1-like protein Lipase_3 PF01764.25 EMD58903.1 - 0.0017 18.3 0.0 0.0029 17.5 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) Palm_thioest PF02089.15 EMD58903.1 - 0.0023 17.8 0.0 0.0035 17.2 0.0 1.3 1 0 0 1 1 1 1 Palmitoyl protein thioesterase RNase_T PF00929.24 EMD58904.1 - 0.00016 22.3 0.0 0.0006 20.4 0.0 2.0 1 1 0 1 1 1 1 Exonuclease Pcc1 PF09341.10 EMD58905.1 - 9.1e-29 99.4 0.9 1.1e-28 99.1 0.9 1.1 1 0 0 1 1 1 1 Transcription factor Pcc1 TPR_12 PF13424.6 EMD58907.1 - 4.1e-17 62.2 0.0 6.2e-12 45.6 0.0 4.1 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_10 PF13374.6 EMD58907.1 - 1.7e-12 46.8 0.2 2.8e-05 23.8 0.0 5.1 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.6 EMD58907.1 - 5.8e-07 29.1 0.0 0.0094 15.9 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 EMD58907.1 - 4.9e-06 26.9 0.0 0.18 12.7 0.0 4.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.17 EMD58907.1 - 1.2e-05 25.0 0.0 0.065 13.4 0.0 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat Paf67 PF10255.9 EMD58907.1 - 0.00015 20.9 0.0 0.00027 20.1 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase I-associated factor PAF67 TPR_19 PF14559.6 EMD58907.1 - 0.0003 21.2 0.0 2.2 8.9 0.0 3.3 2 1 0 3 3 3 2 Tetratricopeptide repeat TPR_4 PF07721.14 EMD58907.1 - 0.001 19.5 0.0 0.25 12.1 0.0 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 EMD58907.1 - 0.035 14.3 0.0 42 4.7 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EMD58907.1 - 0.048 13.9 0.0 1.8 8.9 0.0 3.3 4 1 0 5 5 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.6 EMD58907.1 - 0.051 14.2 0.0 1.5 9.5 0.0 3.1 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 EMD58907.1 - 0.053 13.4 0.0 2.5 8.1 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_MalT PF17874.1 EMD58907.1 - 0.069 12.5 0.0 0.12 11.8 0.0 1.3 1 0 0 1 1 1 0 MalT-like TPR region F-box PF00646.33 EMD58908.1 - 0.069 13.1 0.1 0.14 12.1 0.1 1.5 1 0 0 1 1 1 0 F-box domain WSC PF01822.19 EMD58910.1 - 1.3e-10 41.4 6.4 1.3e-10 41.4 6.4 3.0 3 0 0 3 3 3 1 WSC domain Macoilin PF09726.9 EMD58910.1 - 0.0034 16.0 2.8 0.0036 15.9 2.8 1.1 1 0 0 1 1 1 1 Macoilin family SHE3 PF17078.5 EMD58910.1 - 0.16 11.7 9.6 0.24 11.1 9.6 1.2 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 FapA PF03961.13 EMD58910.1 - 0.2 10.2 4.5 0.23 10.0 2.0 1.9 2 0 0 2 2 2 0 Flagellar Assembly Protein A SPAM PF02090.15 EMD58910.1 - 0.56 10.0 7.6 0.86 9.4 7.6 1.3 1 0 0 1 1 1 0 Salmonella surface presentation of antigen gene type M protein WSC PF01822.19 EMD58911.1 - 2e-15 56.8 12.6 2.2e-15 56.6 12.6 1.0 1 0 0 1 1 1 1 WSC domain DHHC PF01529.20 EMD58913.1 - 1.7e-38 131.8 8.2 1.7e-38 131.8 8.2 1.5 2 0 0 2 2 2 1 DHHC palmitoyltransferase DUF3955 PF13127.6 EMD58913.1 - 0.0056 16.5 4.3 0.011 15.5 4.3 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3955) XRCC4 PF06632.12 EMD58913.1 - 0.054 12.3 1.4 0.14 11.0 1.4 1.6 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 Yip1 PF04893.17 EMD58913.1 - 2.6 7.7 15.0 0.064 13.0 2.2 2.1 2 0 0 2 2 2 0 Yip1 domain HAD_2 PF13419.6 EMD58916.1 - 0.00065 19.8 0.4 0.0012 19.0 0.1 1.5 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EMD58916.1 - 0.02 15.2 0.0 0.062 13.6 0.0 1.8 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EMD58916.1 - 0.057 13.5 0.1 0.11 12.6 0.1 1.5 1 0 0 1 1 1 0 HAD-hyrolase-like FliM PF02154.15 EMD58917.1 - 0.04 13.8 0.0 0.042 13.7 0.0 1.1 1 0 0 1 1 1 0 Flagellar motor switch protein FliM Methyltransf_16 PF10294.9 EMD58918.1 - 5.6e-16 58.8 0.0 7.9e-16 58.3 0.0 1.2 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_25 PF13649.6 EMD58918.1 - 0.033 14.9 0.0 0.089 13.5 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain GidB PF02527.15 EMD58918.1 - 0.047 13.0 0.0 0.07 12.4 0.0 1.3 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G Methyltransf_23 PF13489.6 EMD58918.1 - 0.11 12.3 0.0 0.2 11.5 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain Cons_hypoth95 PF03602.15 EMD58918.1 - 0.12 12.1 0.0 0.23 11.1 0.0 1.4 1 1 0 1 1 1 0 Conserved hypothetical protein 95 Copper-fist PF00649.18 EMD58919.1 - 2.1e-16 59.1 3.6 7.3e-16 57.4 3.6 2.0 1 0 0 1 1 1 1 Copper fist DNA binding domain SUN PF03856.13 EMD58920.1 - 3.5e-76 255.9 13.7 4.6e-76 255.5 13.7 1.1 1 0 0 1 1 1 1 Beta-glucosidase (SUN family) FCH PF00611.23 EMD58921.1 - 3.5e-25 88.1 2.7 6.2e-25 87.3 0.2 2.5 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_9 PF14604.6 EMD58921.1 - 2e-17 62.8 0.7 8.4e-11 41.6 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain C1_1 PF00130.22 EMD58921.1 - 1.1e-14 54.0 5.3 1.7e-14 53.4 5.3 1.3 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) SH3_1 PF00018.28 EMD58921.1 - 3.5e-13 48.9 0.2 6.8e-06 25.6 0.0 2.4 2 0 0 2 2 2 2 SH3 domain C1_2 PF03107.16 EMD58921.1 - 0.019 15.3 5.2 0.034 14.5 5.2 1.4 1 0 0 1 1 1 0 C1 domain SH3_10 PF17902.1 EMD58921.1 - 0.019 15.0 0.0 3.3 7.8 0.0 2.9 2 0 0 2 2 2 0 SH3 domain SH3_3 PF08239.11 EMD58921.1 - 0.052 13.8 0.2 1.8 8.9 0.1 2.5 2 0 0 2 2 2 0 Bacterial SH3 domain DEAD PF00270.29 EMD58922.1 - 2.2e-33 115.5 0.1 6.3e-33 114.0 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EMD58922.1 - 1.6e-26 92.9 0.0 3.4e-26 91.8 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_30 PF13604.6 EMD58922.1 - 0.031 14.0 0.0 0.17 11.6 0.0 2.0 2 0 0 2 2 2 0 AAA domain ATPgrasp_N PF18130.1 EMD58922.1 - 0.042 14.4 0.0 0.24 12.0 0.0 2.3 1 0 0 1 1 1 0 ATP-grasp N-terminal domain Anp1 PF03452.14 EMD58924.1 - 4.5e-110 367.2 0.0 5.2e-110 367.0 0.0 1.0 1 0 0 1 1 1 1 Anp1 Myelin_MBP PF01669.17 EMD58924.1 - 0.013 16.1 1.3 0.015 15.9 0.1 1.7 2 0 0 2 2 2 0 Myelin basic protein Glycos_transf_2 PF00535.26 EMD58924.1 - 0.019 14.8 0.0 0.035 13.9 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase family 2 YEATS PF03366.16 EMD58927.1 - 3.1e-19 68.7 0.1 6.4e-19 67.7 0.1 1.6 1 0 0 1 1 1 1 YEATS family BET PF17035.5 EMD58927.1 - 1e-05 25.6 0.0 1.8e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 Bromodomain extra-terminal - transcription regulation Ran_BP1 PF00638.18 EMD58928.1 - 7.9e-50 168.2 1.5 1.3e-49 167.5 1.5 1.3 1 0 0 1 1 1 1 RanBP1 domain WH1 PF00568.23 EMD58928.1 - 6.4e-05 22.9 0.3 0.00049 20.0 0.3 2.0 1 1 0 1 1 1 1 WH1 domain VID27_PH PF17747.1 EMD58928.1 - 0.00014 22.1 0.0 0.0002 21.6 0.0 1.2 1 0 0 1 1 1 1 VID27 PH-like domain Glyco_transf_15 PF01793.16 EMD58930.1 - 3.8e-98 328.7 9.3 2.4e-97 326.1 9.3 1.9 1 1 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase DUF4604 PF15377.6 EMD58931.1 - 9e-22 78.3 22.4 1e-21 78.1 22.4 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4604) DUF1639 PF07797.14 EMD58931.1 - 0.024 14.6 2.1 0.061 13.3 2.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1639) CDC45 PF02724.14 EMD58931.1 - 1.4 7.2 11.6 1.6 6.9 11.6 1.1 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 EMD58931.1 - 1.6 7.4 8.9 1.8 7.2 8.9 1.1 1 0 0 1 1 1 0 Presenilin Orf78 PF06024.12 EMD58935.1 - 5 7.5 5.5 6.2 7.2 4.5 1.6 1 1 0 1 1 1 0 Orf78 (ac78) WD40 PF00400.32 EMD58937.1 - 1.5e-70 231.3 12.2 1.8e-10 41.2 0.1 7.5 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD58937.1 - 8.1e-28 96.6 0.0 7e-05 23.1 0.0 6.5 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EMD58937.1 - 5.1e-18 65.1 3.5 0.092 11.7 0.0 6.5 1 1 5 6 6 6 6 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 EMD58937.1 - 5.9e-11 41.7 9.8 0.38 9.3 0.1 6.2 1 1 5 6 6 6 6 Nucleoporin Nup120/160 Proteasome_A_N PF10584.9 EMD58937.1 - 3.2e-09 36.3 0.0 22 4.8 0.0 7.5 7 0 0 7 7 7 0 Proteasome subunit A N-terminal signature AAA_16 PF13191.6 EMD58937.1 - 1.4e-08 35.4 4.1 3.3e-06 27.6 0.1 3.6 3 0 0 3 3 3 1 AAA ATPase domain eIF2A PF08662.11 EMD58937.1 - 6.1e-08 32.8 0.0 0.062 13.2 0.0 3.5 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Helo_like_N PF17111.5 EMD58937.1 - 7e-08 32.1 0.4 1.4e-07 31.1 0.4 1.4 1 0 0 1 1 1 1 Fungal N-terminal domain of STAND proteins NACHT PF05729.12 EMD58937.1 - 7.7e-08 32.4 0.1 2.4e-07 30.8 0.1 1.9 1 0 0 1 1 1 1 NACHT domain PD40 PF07676.12 EMD58937.1 - 2.2e-07 30.6 1.0 40 4.3 0.0 7.8 8 0 0 8 8 8 0 WD40-like Beta Propeller Repeat SesA PF17107.5 EMD58937.1 - 4.7e-05 23.6 0.3 0.00014 22.1 0.3 1.8 1 0 0 1 1 1 1 N-terminal domain on NACHT_NTPase and P-loop NTPases IKI3 PF04762.12 EMD58937.1 - 0.00011 20.5 0.0 2.2 6.1 0.0 3.7 1 1 2 3 3 3 3 IKI3 family AAA PF00004.29 EMD58937.1 - 0.00023 21.6 0.1 0.00082 19.8 0.1 1.9 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) TruB_C PF09142.11 EMD58937.1 - 0.002 17.8 4.9 78 3.2 0.0 6.1 6 0 0 6 6 6 0 tRNA Pseudouridine synthase II, C terminal NB-ARC PF00931.22 EMD58937.1 - 0.0047 16.1 0.0 0.01 15.1 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain Defensin_RK-1 PF17860.1 EMD58937.1 - 0.0054 17.2 0.1 3.3e+02 1.9 0.0 5.4 6 0 0 6 6 6 0 RK-1-like defensin AAA_22 PF13401.6 EMD58937.1 - 0.0077 16.5 0.1 0.033 14.5 0.0 2.1 2 0 0 2 2 1 1 AAA domain APS_kinase PF01583.20 EMD58937.1 - 0.017 15.0 0.1 0.044 13.7 0.1 1.7 1 0 0 1 1 1 0 Adenylylsulphate kinase PIF1 PF05970.14 EMD58937.1 - 0.028 13.6 0.0 0.046 12.9 0.0 1.3 1 0 0 1 1 1 0 PIF1-like helicase SurE PF01975.17 EMD58937.1 - 0.031 14.0 8.0 8.8 6.0 0.4 4.6 1 1 5 6 6 6 0 Survival protein SurE AAA_24 PF13479.6 EMD58937.1 - 0.053 13.2 0.0 0.14 11.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 EMD58937.1 - 0.073 12.8 1.0 0.13 12.0 0.1 1.8 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 EMD58937.1 - 0.1 13.1 0.1 0.49 10.9 0.0 2.1 2 0 0 2 2 1 0 AAA domain RNA_helicase PF00910.22 EMD58937.1 - 0.12 12.8 0.1 0.45 10.9 0.0 2.0 2 0 0 2 2 2 0 RNA helicase PhoH PF02562.16 EMD58937.1 - 0.18 11.2 0.0 4.5 6.7 0.1 2.3 2 0 0 2 2 2 0 PhoH-like protein AAA_11 PF13086.6 EMD58941.1 - 7.9e-60 202.8 0.1 7.9e-60 202.8 0.1 2.0 2 1 1 3 3 2 1 AAA domain AAA_12 PF13087.6 EMD58941.1 - 1.6e-56 191.1 0.0 1.8e-55 187.7 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EMD58941.1 - 4.3e-12 46.1 0.0 9.1e-11 41.8 0.0 2.7 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EMD58941.1 - 1.3e-10 41.8 0.1 1.7e-09 38.1 0.1 2.8 3 1 0 3 3 2 1 AAA domain UvrD-helicase PF00580.21 EMD58941.1 - 1.7e-07 31.1 0.1 3.8e-05 23.4 0.1 2.5 1 1 1 2 2 2 1 UvrD/REP helicase N-terminal domain DUF2075 PF09848.9 EMD58941.1 - 2.4e-06 27.1 1.6 1.6e-05 24.4 1.6 2.4 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) UvrD_C PF13361.6 EMD58941.1 - 6.9e-06 25.7 0.1 2.9 7.2 0.0 3.6 2 2 0 3 3 3 3 UvrD-like helicase C-terminal domain ResIII PF04851.15 EMD58941.1 - 1.1e-05 25.5 0.0 4.2e-05 23.6 0.0 2.0 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit UvrD_C_2 PF13538.6 EMD58941.1 - 2.1e-05 24.2 0.1 0.056 13.3 0.0 2.7 2 0 0 2 2 2 2 UvrD-like helicase C-terminal domain Viral_helicase1 PF01443.18 EMD58941.1 - 2.9e-05 23.9 0.0 1.1 9.0 0.0 3.3 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase AAA_22 PF13401.6 EMD58941.1 - 0.00042 20.6 0.2 0.0036 17.6 0.2 2.6 2 1 0 2 2 1 1 AAA domain Helicase_RecD PF05127.14 EMD58941.1 - 0.00064 19.6 0.0 0.058 13.2 0.0 2.8 1 1 0 1 1 1 1 Helicase AAA_16 PF13191.6 EMD58941.1 - 0.001 19.5 0.2 0.0024 18.3 0.2 1.8 1 1 0 1 1 1 1 AAA ATPase domain PhoH PF02562.16 EMD58941.1 - 0.0019 17.7 0.0 0.081 12.4 0.0 2.4 2 0 0 2 2 2 1 PhoH-like protein T2SSE PF00437.20 EMD58941.1 - 0.0025 16.9 0.0 0.0063 15.6 0.0 1.7 1 0 0 1 1 1 1 Type II/IV secretion system protein Flavi_DEAD PF07652.14 EMD58941.1 - 0.0082 16.1 0.0 0.024 14.6 0.0 1.9 2 0 0 2 2 1 1 Flavivirus DEAD domain PCB_OB PF17092.5 EMD58941.1 - 0.021 15.6 3.7 1.3 9.8 0.2 3.6 2 1 1 3 3 3 0 Penicillin-binding protein OB-like domain AAA PF00004.29 EMD58941.1 - 0.021 15.3 0.1 0.06 13.8 0.1 1.9 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) 4HB_MCP_1 PF12729.7 EMD58941.1 - 0.023 14.3 0.8 0.023 14.3 0.8 1.8 2 0 0 2 2 1 0 Four helix bundle sensory module for signal transduction AAA_25 PF13481.6 EMD58941.1 - 0.025 14.1 0.1 0.18 11.4 0.0 2.5 3 0 0 3 3 3 0 AAA domain AAA_5 PF07728.14 EMD58941.1 - 0.028 14.4 0.0 0.13 12.2 0.0 2.1 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) CpcD PF01383.21 EMD58941.1 - 0.048 13.9 0.1 0.13 12.6 0.1 1.7 1 0 0 1 1 1 0 CpcD/allophycocyanin linker domain FtsK_SpoIIIE PF01580.18 EMD58941.1 - 0.051 12.9 1.5 1.2 8.5 1.5 2.3 1 1 0 1 1 1 0 FtsK/SpoIIIE family AAA_24 PF13479.6 EMD58941.1 - 0.053 13.2 0.0 0.21 11.3 0.0 2.0 1 1 0 1 1 1 0 AAA domain AAA_23 PF13476.6 EMD58941.1 - 0.075 13.5 8.4 2.1 8.8 0.0 2.9 2 1 0 3 3 3 0 AAA domain AAA_33 PF13671.6 EMD58941.1 - 0.077 13.2 0.5 0.31 11.2 0.1 2.3 2 1 0 2 2 1 0 AAA domain Mg_chelatase PF01078.21 EMD58941.1 - 0.096 12.1 0.0 0.19 11.1 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI ABC_tran PF00005.27 EMD58941.1 - 0.11 13.1 0.1 0.4 11.2 0.0 2.1 2 1 0 2 2 1 0 ABC transporter GNVR PF13807.6 EMD58941.1 - 0.21 11.5 2.2 0.37 10.7 0.3 2.4 3 0 0 3 3 2 0 G-rich domain on putative tyrosine kinase COesterase PF00135.28 EMD58943.1 - 2.1e-81 274.3 0.0 2.7e-81 274.0 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EMD58943.1 - 0.00023 21.1 0.0 0.0025 17.7 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Sugar_tr PF00083.24 EMD58945.1 - 6.6e-134 447.2 57.5 4.7e-130 434.5 30.3 3.2 3 0 0 3 3 3 3 Sugar (and other) transporter MFS_1 PF07690.16 EMD58945.1 - 5.8e-33 114.3 74.6 8.1e-23 80.9 26.1 4.2 2 2 2 4 4 4 4 Major Facilitator Superfamily MFS_4 PF06779.14 EMD58945.1 - 0.00027 20.3 15.0 0.00027 20.3 15.0 3.8 3 1 0 3 3 3 2 Uncharacterised MFS-type transporter YbfB DUF2530 PF10745.9 EMD58945.1 - 2.8 8.2 15.0 0.11 12.8 2.0 3.8 3 1 1 4 4 4 0 Protein of unknown function (DUF2530) adh_short_C2 PF13561.6 EMD58946.1 - 2.9e-61 207.0 5.5 3.3e-61 206.8 5.5 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EMD58946.1 - 3.3e-44 150.7 4.0 4.3e-44 150.3 4.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EMD58946.1 - 7.3e-16 58.6 4.4 1.1e-15 58.1 4.4 1.1 1 0 0 1 1 1 1 KR domain YAcAr PF10686.9 EMD58946.1 - 0.021 14.8 0.2 0.048 13.6 0.2 1.6 1 0 0 1 1 1 0 YspA, cpYpsA-related SLOG family THF_DHG_CYH_C PF02882.19 EMD58946.1 - 0.033 13.5 0.8 0.1 11.9 0.0 2.1 2 1 1 3 3 3 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain 3HCDH_N PF02737.18 EMD58946.1 - 0.07 13.0 1.5 0.13 12.1 1.5 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Nop16 PF09420.10 EMD58947.1 - 4.2e-61 206.6 9.7 4.8e-61 206.4 9.7 1.0 1 0 0 1 1 1 1 Ribosome biogenesis protein Nop16 Toxin_YhaV PF11663.8 EMD58947.1 - 0.012 15.6 0.2 0.049 13.7 0.0 2.0 2 0 0 2 2 2 0 Toxin with endonuclease activity, of toxin-antitoxin system Myb_DNA-binding PF00249.31 EMD58947.1 - 0.026 14.7 0.1 0.056 13.7 0.1 1.6 1 0 0 1 1 1 0 Myb-like DNA-binding domain DUF5024 PF16427.5 EMD58947.1 - 0.087 13.2 2.0 0.091 13.1 0.0 2.0 3 0 0 3 3 3 0 Domain of unknown function (DUF5024) Zip PF02535.22 EMD58948.1 - 4.2e-59 200.4 6.4 1.3e-58 198.9 6.4 1.7 1 1 0 1 1 1 1 ZIP Zinc transporter Phage_holin_Dp1 PF16938.5 EMD58948.1 - 0.16 12.2 1.5 0.85 9.9 0.3 2.5 2 0 0 2 2 2 0 Putative phage holin Dp-1 Pkinase PF00069.25 EMD58950.1 - 2e-12 47.1 0.0 7.4e-10 38.6 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain IBR PF01485.21 EMD58950.1 - 1.2e-08 35.0 5.1 2.7e-08 33.9 5.1 1.5 1 0 0 1 1 1 1 IBR domain, a half RING-finger domain Pkinase_Tyr PF07714.17 EMD58950.1 - 3.9e-06 26.4 0.0 1.5e-05 24.4 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Ribosomal_L39 PF00832.20 EMD58950.1 - 0.13 11.9 2.2 0.29 10.8 2.2 1.6 1 0 0 1 1 1 0 Ribosomal L39 protein zf-RING_4 PF14570.6 EMD58950.1 - 0.31 10.9 6.5 0.63 9.9 6.5 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain adh_short PF00106.25 EMD58951.1 - 2e-25 89.4 0.0 4.8e-18 65.3 0.0 2.2 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EMD58951.1 - 6.7e-19 68.4 0.0 7.7e-12 45.3 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD58951.1 - 2.6e-06 27.5 0.1 4.8e-06 26.6 0.1 1.4 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EMD58951.1 - 0.00013 21.2 0.0 0.00019 20.7 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein ApoLp-III PF07464.11 EMD58951.1 - 0.032 14.3 0.1 0.059 13.5 0.1 1.4 1 0 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) DEK_C PF08766.11 EMD58951.1 - 0.038 13.9 0.0 1.1 9.2 0.0 2.5 2 0 0 2 2 2 0 DEK C terminal domain FAD_binding_3 PF01494.19 EMD58952.1 - 8.2e-13 48.3 2.2 1.6e-09 37.5 0.2 3.0 2 1 0 2 2 2 2 FAD binding domain Pyr_redox_2 PF07992.14 EMD58952.1 - 6.1e-08 32.2 0.4 0.0025 17.1 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EMD58952.1 - 0.00051 19.2 0.0 0.00095 18.3 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 EMD58952.1 - 0.0018 18.4 0.1 0.0054 16.9 0.1 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EMD58952.1 - 0.0031 17.2 0.5 0.016 14.8 0.2 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase HI0933_like PF03486.14 EMD58952.1 - 0.091 11.4 0.1 1.1 7.8 0.0 2.0 2 0 0 2 2 2 0 HI0933-like protein Pyr_redox PF00070.27 EMD58952.1 - 0.14 12.8 0.3 20 5.8 0.1 2.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EMD58952.1 - 0.17 10.9 0.1 0.32 10.0 0.1 1.5 1 1 0 1 1 1 0 Glucose inhibited division protein A Sugar_tr PF00083.24 EMD58953.1 - 1.3e-82 278.1 22.4 1.5e-82 277.9 22.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD58953.1 - 7.4e-20 71.2 29.9 1.6e-19 70.1 22.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 EMD58953.1 - 2.1e-05 24.0 3.7 2.1e-05 24.0 3.7 2.6 2 1 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB OATP PF03137.20 EMD58953.1 - 0.0013 17.1 7.1 0.0044 15.4 7.0 1.8 1 1 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family DUF1772 PF08592.11 EMD58953.1 - 0.53 10.6 13.7 1.8 8.9 0.1 3.8 2 1 0 3 3 3 0 Domain of unknown function (DUF1772) DUF1765 PF08578.10 EMD58954.1 - 0.014 15.8 0.1 0.033 14.7 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1765) p450 PF00067.22 EMD58955.1 - 9e-63 212.6 0.0 1.1e-62 212.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Trp_DMAT PF11991.8 EMD58956.1 - 1.3e-106 357.1 0.0 1.6e-106 356.8 0.0 1.1 1 0 0 1 1 1 1 Tryptophan dimethylallyltransferase AMP-binding PF00501.28 EMD58957.1 - 5.3e-95 318.5 0.0 6.7e-95 318.2 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EMD58957.1 - 2.6e-16 60.4 0.1 6.4e-16 59.1 0.1 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain NDUF_B7 PF05676.13 EMD58958.1 - 1.3e-30 104.9 6.6 1.6e-30 104.6 6.6 1.1 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) Ank_2 PF12796.7 EMD58959.1 - 3.4e-12 46.8 0.1 0.00011 22.7 0.0 3.0 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMD58959.1 - 1.2e-09 38.5 0.1 4.4e-05 24.0 0.0 3.2 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 EMD58959.1 - 3.8e-08 33.5 0.7 3.2e-05 24.1 0.1 3.3 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMD58959.1 - 2.8e-07 30.3 0.3 0.16 12.6 0.0 4.4 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.30 EMD58959.1 - 4.7e-07 30.0 0.3 0.18 12.4 0.0 4.3 4 0 0 4 4 4 2 Ankyrin repeat KilA-N PF04383.13 EMD58959.1 - 3.5e-05 23.6 0.4 0.00024 20.9 0.1 2.5 2 1 0 2 2 2 1 KilA-N domain RskA PF10099.9 EMD58959.1 - 0.00079 19.8 5.9 0.00079 19.8 5.9 1.9 2 0 0 2 2 2 1 Anti-sigma-K factor rskA MbeD_MobD PF04899.12 EMD58959.1 - 0.0036 17.4 1.9 0.012 15.7 1.0 2.4 2 0 0 2 2 2 1 MbeD/MobD like Cupin_4 PF08007.12 EMD58959.1 - 0.025 14.1 1.4 0.075 12.5 1.4 1.8 1 0 0 1 1 1 0 Cupin superfamily protein Draxin PF15550.6 EMD58959.1 - 5.1 6.9 7.4 0.67 9.8 2.8 1.9 2 0 0 2 2 2 0 Draxin EamA PF00892.20 EMD58960.1 - 2.1e-09 37.6 22.1 3.5e-07 30.5 1.3 2.5 2 0 0 2 2 2 2 EamA-like transporter family CSG2 PF16965.5 EMD58960.1 - 0.002 17.1 8.0 0.0093 15.0 6.9 2.4 2 1 0 2 2 2 1 Ceramide synthase regulator SLC35F PF06027.12 EMD58960.1 - 0.013 15.0 0.2 0.05 13.1 0.2 1.9 1 1 0 1 1 1 0 Solute carrier family 35 DUF4579 PF15158.6 EMD58960.1 - 0.028 14.2 1.7 0.27 11.0 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4579) COX8 PF02285.15 EMD58960.1 - 0.27 11.1 2.2 0.29 11.1 0.1 2.3 2 0 0 2 2 2 0 Cytochrome oxidase c subunit VIII TPT PF03151.16 EMD58960.1 - 1.8 7.9 9.2 1.1 8.6 1.3 2.3 2 0 0 2 2 2 0 Triose-phosphate Transporter family PTPA PF03095.15 EMD58961.1 - 4.3e-110 367.9 0.0 5.1e-110 367.7 0.0 1.0 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein GSHPx PF00255.19 EMD58962.1 - 1.2e-37 127.8 0.2 1.5e-37 127.5 0.2 1.1 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.21 EMD58962.1 - 0.0025 17.7 0.1 0.0046 16.9 0.1 1.6 1 1 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EMD58962.1 - 0.023 14.4 0.1 0.029 14.1 0.1 1.5 1 1 0 1 1 1 0 Redoxin Poly_export PF02563.16 EMD58962.1 - 0.1 12.8 0.1 1.7 8.9 0.0 2.4 1 1 1 2 2 2 0 Polysaccharide biosynthesis/export protein RHIM PF12721.7 EMD58963.1 - 0.17 12.4 0.0 0.31 11.6 0.0 1.4 1 0 0 1 1 1 0 RIP homotypic interaction motif zf-C2H2_4 PF13894.6 EMD58964.1 - 2.1 9.4 7.3 27 6.0 0.5 3.2 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2 PF00096.26 EMD58964.1 - 2.8 8.6 11.0 1.1 9.9 3.0 3.0 2 0 0 2 2 2 0 Zinc finger, C2H2 type XAP5 PF04921.14 EMD58964.1 - 7.5 6.3 8.3 0.83 9.4 2.5 2.1 2 0 0 2 2 2 0 XAP5, circadian clock regulator DUF1771 PF08590.10 EMD58967.1 - 3.3e-24 85.0 10.5 3.3e-24 85.0 10.5 2.7 2 0 0 2 2 2 1 Domain of unknown function (DUF1771) Use1 PF09753.9 EMD58967.1 - 1.8e-14 54.1 0.7 1.8e-14 54.1 0.7 2.0 2 0 0 2 2 2 1 Membrane fusion protein Use1 Smr PF01713.21 EMD58967.1 - 2.6e-11 43.7 0.4 6.6e-11 42.4 0.4 1.8 1 0 0 1 1 1 1 Smr domain Synaptobrevin PF00957.21 EMD58967.1 - 0.049 13.4 0.0 0.049 13.4 0.0 3.3 4 0 0 4 4 4 0 Synaptobrevin Chordopox_A30L PF06015.12 EMD58967.1 - 0.11 12.3 1.3 0.17 11.7 0.2 1.9 2 0 0 2 2 2 0 Chordopoxvirus A30L protein DUF3891 PF13030.6 EMD58968.1 - 0.043 13.6 0.2 0.051 13.3 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3891) PI-PLC-X PF00388.19 EMD58969.1 - 3e-63 211.7 0.0 6.1e-63 210.7 0.0 1.6 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 EMD58969.1 - 8.6e-42 142.1 0.0 1.6e-41 141.3 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain GDPD PF03009.17 EMD58969.1 - 0.002 17.9 0.0 0.0036 17.1 0.0 1.3 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family EF-hand_like PF09279.11 EMD58969.1 - 0.0044 17.5 0.1 0.16 12.5 0.1 2.4 2 0 0 2 2 2 1 Phosphoinositide-specific phospholipase C, efhand-like Condensation PF00668.20 EMD58969.1 - 0.048 12.3 0.0 0.091 11.4 0.0 1.4 1 0 0 1 1 1 0 Condensation domain Acyl-CoA_dh_1 PF00441.24 EMD58969.1 - 0.1 12.8 0.0 0.2 11.9 0.0 1.4 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase, C-terminal domain K_channel_TID PF07941.11 EMD58970.1 - 0.022 15.2 3.3 0.022 15.2 3.3 3.7 4 0 0 4 4 4 0 Potassium channel Kv1.4 tandem inactivation domain Hydrolase_6 PF13344.6 EMD58972.1 - 8e-23 80.5 0.0 1.5e-22 79.6 0.0 1.5 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EMD58972.1 - 1.3e-12 47.6 0.0 4.4e-12 45.9 0.0 2.0 1 1 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 EMD58972.1 - 0.015 15.6 0.0 7.9 6.7 0.0 2.5 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase TRP PF06011.12 EMD58973.1 - 0.17 10.6 0.0 0.17 10.6 0.0 1.1 1 0 0 1 1 1 0 Transient receptor potential (TRP) ion channel Cu-oxidase_2 PF07731.14 EMD58974.1 - 4.4e-22 78.3 3.2 2.9e-20 72.4 1.1 2.8 2 0 0 2 2 2 2 Multicopper oxidase Cu-oxidase_3 PF07732.15 EMD58974.1 - 6.3e-20 71.4 1.1 1.3e-18 67.1 0.1 2.8 3 0 0 3 3 3 1 Multicopper oxidase Cu-oxidase PF00394.22 EMD58974.1 - 0.001 19.2 0.0 0.0066 16.6 0.0 2.3 2 0 0 2 2 2 1 Multicopper oxidase Pro_isomerase PF00160.21 EMD58975.1 - 3e-44 151.1 0.1 7.9e-44 149.7 0.0 1.8 2 0 0 2 2 2 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD U-box PF04564.15 EMD58975.1 - 3.5e-05 23.9 0.1 0.00019 21.6 0.1 2.1 1 1 1 2 2 2 1 U-box domain Rtf2 PF04641.12 EMD58975.1 - 0.00062 19.2 2.7 0.00092 18.6 0.2 2.4 2 1 0 2 2 2 1 Rtf2 RING-finger zf-NOSIP PF15906.5 EMD58975.1 - 0.0031 17.6 0.0 0.0079 16.3 0.0 1.6 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein ADH_N PF08240.12 EMD58976.1 - 9.7e-27 93.0 4.2 9.7e-27 93.0 4.2 1.7 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EMD58976.1 - 1.3e-13 51.0 0.0 2.4e-13 50.2 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EMD58976.1 - 0.00036 21.6 0.0 0.00072 20.6 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ELFV_dehydrog PF00208.21 EMD58976.1 - 0.0059 16.4 0.2 0.0099 15.6 0.2 1.3 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 2-Hacid_dh_C PF02826.19 EMD58976.1 - 0.057 12.8 0.1 0.093 12.1 0.1 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain T4BSS_DotH_IcmK PF12293.8 EMD58976.1 - 0.11 11.8 0.0 0.18 11.0 0.0 1.3 1 0 0 1 1 1 0 Putative outer membrane core complex of type IVb secretion WYL_3 PF18488.1 EMD58976.1 - 0.23 11.9 0.0 0.44 10.9 0.0 1.4 1 0 0 1 1 1 0 WYL domain SPX PF03105.19 EMD58977.1 - 0.015 15.3 8.9 0.016 15.1 8.9 1.1 1 0 0 1 1 1 0 SPX domain Apt1 PF10351.9 EMD58977.1 - 0.43 9.4 14.5 0.52 9.1 14.5 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain SOBP PF15279.6 EMD58977.1 - 0.98 10.0 10.4 1.3 9.5 10.4 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein SOG2 PF10428.9 EMD58977.1 - 2.3 7.3 23.6 3 6.9 23.6 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein Tmemb_cc2 PF10267.9 EMD58977.1 - 2.5 7.2 6.3 3.6 6.6 6.3 1.2 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein NPR3 PF03666.13 EMD58977.1 - 2.5 6.8 7.9 3.2 6.4 7.9 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF4614 PF15391.6 EMD58977.1 - 3.1 7.7 22.7 4.7 7.2 22.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) Macoilin PF09726.9 EMD58977.1 - 7.4 5.0 15.7 9.6 4.6 15.7 1.1 1 0 0 1 1 1 0 Macoilin family Abhydrolase_6 PF12697.7 EMD58978.1 - 7.7e-05 23.4 0.4 0.00015 22.5 0.4 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family PGAP1 PF07819.13 EMD58978.1 - 0.0015 18.3 0.1 0.0029 17.4 0.1 1.5 1 1 0 1 1 1 1 PGAP1-like protein DUF676 PF05057.14 EMD58978.1 - 0.0016 18.0 0.0 0.0026 17.3 0.0 1.3 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Hydrolase_4 PF12146.8 EMD58978.1 - 0.024 13.9 0.0 0.045 13.0 0.0 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 LCAT PF02450.15 EMD58978.1 - 0.026 13.7 0.0 0.045 12.9 0.0 1.3 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase DUF1451 PF07295.11 EMD58979.1 - 0.32 11.0 1.3 0.88 9.6 0.1 2.3 3 0 0 3 3 3 0 Zinc-ribbon containing domain 6PF2K PF01591.18 EMD58981.1 - 1.3e-61 207.8 0.0 1.9e-61 207.3 0.0 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 EMD58981.1 - 1.9e-22 79.9 0.3 1.8e-21 76.8 0.3 2.2 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) DUF1771 PF08590.10 EMD58981.1 - 0.0046 17.3 0.3 0.38 11.2 0.1 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF1771) AAA_33 PF13671.6 EMD58981.1 - 0.007 16.5 0.0 0.017 15.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.10 EMD58981.1 - 0.055 12.9 0.0 0.17 11.3 0.0 1.8 1 1 0 1 1 1 0 Chromatin associated protein KTI12 Porin_3 PF01459.22 EMD58982.1 - 1.1e-79 267.7 0.0 1.3e-79 267.4 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic porin Tom22 PF04281.13 EMD58983.1 - 3e-45 153.4 2.5 3.3e-45 153.3 2.5 1.0 1 0 0 1 1 1 1 Mitochondrial import receptor subunit Tom22 Amidohydro_2 PF04909.14 EMD58984.1 - 2.9e-40 138.9 0.3 3.4e-40 138.7 0.3 1.0 1 0 0 1 1 1 1 Amidohydrolase NACHT PF05729.12 EMD58985.1 - 4.2e-07 30.0 0.1 1.3e-06 28.4 0.1 2.1 1 1 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 EMD58985.1 - 0.00064 20.1 0.0 0.0027 18.1 0.0 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EMD58985.1 - 0.00074 19.8 0.0 0.0045 17.2 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EMD58985.1 - 0.0035 17.9 0.1 0.054 14.1 0.0 2.5 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.27 EMD58985.1 - 0.017 15.6 0.0 0.064 13.8 0.0 1.9 1 0 0 1 1 1 0 ABC transporter AAA_33 PF13671.6 EMD58985.1 - 0.019 15.1 0.0 0.093 12.9 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 EMD58985.1 - 0.025 14.3 0.0 0.054 13.2 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain NTPase_1 PF03266.15 EMD58985.1 - 0.069 13.1 0.0 0.69 9.8 0.0 2.3 2 0 0 2 2 2 0 NTPase FtsK_SpoIIIE PF01580.18 EMD58985.1 - 0.12 11.7 0.0 0.3 10.4 0.0 1.6 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_24 PF13479.6 EMD58985.1 - 0.14 11.8 0.0 0.31 10.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EMD58985.1 - 0.19 12.1 0.0 0.54 10.7 0.0 1.8 1 0 0 1 1 1 0 RNA helicase GCS PF03074.16 EMD58986.1 - 1.2e-175 584.3 0.0 1.4e-175 584.0 0.0 1.1 1 0 0 1 1 1 1 Glutamate-cysteine ligase GATA PF00320.27 EMD58987.1 - 3.9e-15 55.2 5.3 6.6e-15 54.4 5.3 1.4 1 0 0 1 1 1 1 GATA zinc finger zinc_ribbon_9 PF14369.6 EMD58987.1 - 0.43 10.9 1.6 0.98 9.7 1.6 1.6 1 0 0 1 1 1 0 zinc-ribbon DUF2014 PF09427.10 EMD58991.1 - 1.5e-108 362.1 4.4 1.5e-108 362.1 4.4 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF2014) HLH PF00010.26 EMD58991.1 - 4.5e-17 61.7 0.2 1.1e-16 60.4 0.2 1.8 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Macoilin PF09726.9 EMD58991.1 - 0.33 9.5 11.1 0.52 8.8 11.1 1.2 1 0 0 1 1 1 0 Macoilin family TFIIA PF03153.13 EMD58991.1 - 0.37 10.7 22.5 0.68 9.9 22.5 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 EMD58991.1 - 0.44 10.1 14.3 1.2 8.7 14.3 1.7 1 0 0 1 1 1 0 Spt20 family MAP65_ASE1 PF03999.12 EMD58991.1 - 6.4 5.3 17.3 13 4.3 17.3 1.4 1 1 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) Kdo PF06293.14 EMD58993.1 - 7.7e-09 35.2 0.1 2.1e-06 27.3 0.1 2.8 2 1 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EMD58993.1 - 7.4e-08 32.6 0.2 0.018 15.0 0.2 3.1 2 1 1 3 3 3 2 Phosphotransferase enzyme family Pkinase PF00069.25 EMD58993.1 - 8e-06 25.4 0.0 1.2e-05 24.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain RIO1 PF01163.22 EMD58993.1 - 3.6e-05 23.5 0.0 7.2e-05 22.5 0.0 1.5 1 0 0 1 1 1 1 RIO1 family Pkinase_Tyr PF07714.17 EMD58993.1 - 0.0034 16.7 0.0 0.0049 16.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Choline_kinase PF01633.20 EMD58993.1 - 0.01 15.4 0.0 0.015 14.9 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase MYCBPAP PF14646.6 EMD58993.1 - 0.18 10.7 0.0 0.22 10.4 0.0 1.1 1 0 0 1 1 1 0 MYCBP-associated protein family EB PF01683.18 EMD58995.1 - 0.36 11.2 3.9 0.55 10.6 3.9 1.3 1 0 0 1 1 1 0 EB module Cu_bind_like PF02298.17 EMD58996.1 - 0.0035 17.3 0.1 0.02 14.9 0.1 2.0 1 1 0 1 1 1 1 Plastocyanin-like domain Cupredoxin_1 PF13473.6 EMD58996.1 - 0.007 16.5 0.2 0.013 15.6 0.2 1.4 1 0 0 1 1 1 1 Cupredoxin-like domain CBM39 PF15886.5 EMD58996.1 - 0.036 13.9 0.0 0.068 13.1 0.0 1.4 1 0 0 1 1 1 0 Carbohydrate binding domain (family 32) Copper-bind PF00127.20 EMD58996.1 - 0.12 12.8 2.0 0.4 11.2 2.0 1.9 1 1 0 1 1 1 0 Copper binding proteins, plastocyanin/azurin family FAD_binding_4 PF01565.23 EMD58997.1 - 1.1e-27 96.5 0.5 1.1e-27 96.5 0.5 1.7 2 0 0 2 2 2 1 FAD binding domain BBE PF08031.12 EMD58997.1 - 0.00081 19.4 0.0 0.0017 18.4 0.0 1.6 1 0 0 1 1 1 1 Berberine and berberine like DNA_pol_B PF00136.21 EMD58998.1 - 2e-145 485.0 0.3 2.8e-145 484.5 0.3 1.2 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 EMD58998.1 - 1.1e-79 268.1 0.2 2e-79 267.2 0.2 1.5 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.6 EMD58998.1 - 3.1e-18 66.0 8.1 8.9e-18 64.5 8.1 1.9 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta DNA_pol_B_exo2 PF10108.9 EMD58998.1 - 3.7e-05 23.5 0.4 0.00012 21.8 0.4 1.7 1 1 0 1 1 1 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB DNA_pol_B_2 PF03175.13 EMD58998.1 - 0.0001 21.3 0.4 0.00075 18.5 0.0 2.2 2 0 0 2 2 2 1 DNA polymerase type B, organellar and viral RNase_H_2 PF13482.6 EMD58998.1 - 0.028 14.4 0.4 0.16 12.0 0.4 2.2 1 1 0 1 1 1 0 RNase_H superfamily DHHA2 PF02833.14 EMD58998.1 - 0.053 13.7 0.3 0.28 11.4 0.0 2.3 2 0 0 2 2 2 0 DHHA2 domain DUF2614 PF11023.8 EMD58998.1 - 0.14 12.2 0.2 0.32 11.1 0.2 1.5 1 0 0 1 1 1 0 Zinc-ribbon containing domain C1_1 PF00130.22 EMD58998.1 - 0.54 10.2 10.0 0.57 10.1 1.0 2.6 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Acetyltransf_10 PF13673.7 EMD58999.1 - 4.3e-08 33.2 0.0 7e-08 32.5 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EMD58999.1 - 1e-06 29.1 0.0 1.8e-06 28.3 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EMD58999.1 - 1.3e-05 25.3 0.0 2.4e-05 24.5 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_9 PF13527.7 EMD58999.1 - 0.00016 21.7 0.3 0.011 15.8 0.0 2.8 2 1 1 3 3 3 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EMD58999.1 - 0.0006 19.9 0.0 0.0018 18.3 0.0 1.8 1 1 1 2 2 2 1 GCN5-related N-acetyl-transferase Amidohydro_2 PF04909.14 EMD59000.1 - 4.3e-30 105.5 0.0 5.7e-30 105.1 0.0 1.2 1 0 0 1 1 1 1 Amidohydrolase TatD_DNase PF01026.21 EMD59000.1 - 0.003 17.0 0.0 0.081 12.3 0.0 2.2 2 1 0 2 2 2 2 TatD related DNase Pyridoxal_deC PF00282.19 EMD59001.1 - 1.3e-114 382.8 0.0 1.6e-114 382.5 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Beta_elim_lyase PF01212.21 EMD59001.1 - 0.00031 20.1 0.0 0.00063 19.1 0.0 1.4 1 1 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.21 EMD59001.1 - 0.065 12.4 0.0 0.12 11.5 0.0 1.4 1 0 0 1 1 1 0 Aminotransferase class I and II Bystin PF05291.11 EMD59003.1 - 4.4e-126 420.1 0.0 6.4e-126 419.5 0.0 1.2 1 0 0 1 1 1 1 Bystin Pyr_redox_2 PF07992.14 EMD59004.1 - 9.2e-52 176.1 0.0 1.2e-51 175.8 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EMD59004.1 - 3.8e-11 43.4 0.0 9e-10 39.0 0.0 2.6 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EMD59004.1 - 0.0075 15.6 0.0 3.6 6.8 0.0 2.6 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase PQ-loop PF04193.14 EMD59005.1 - 9.4e-15 54.1 0.5 1.8e-14 53.2 0.5 1.5 1 0 0 1 1 1 1 PQ loop repeat DUF2830 PF11125.8 EMD59006.1 - 0.14 12.2 1.5 0.2 11.7 1.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2830) DIOX_N PF14226.6 EMD59009.1 - 3.8e-25 88.9 0.0 6.5e-25 88.2 0.0 1.4 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EMD59009.1 - 2.2e-17 63.4 0.0 3.5e-17 62.7 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Glyco_hydro_20 PF00728.22 EMD59010.1 - 8.9e-25 87.8 0.4 5e-22 78.8 0.4 2.5 1 1 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glyco_hydro_20b PF02838.15 EMD59010.1 - 4.2e-09 37.2 0.0 1.3e-08 35.7 0.0 1.8 2 0 0 2 2 2 1 Glycosyl hydrolase family 20, domain 2 FAD_binding_4 PF01565.23 EMD59011.1 - 4.3e-13 49.2 0.0 6.7e-13 48.6 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain IPPT PF01715.17 EMD59013.1 - 3.8e-66 223.2 0.0 5.5e-66 222.6 0.0 1.2 1 0 0 1 1 1 1 IPP transferase IPT PF01745.16 EMD59013.1 - 7.7e-05 22.2 0.0 0.00061 19.3 0.0 2.1 2 0 0 2 2 2 1 Isopentenyl transferase AAA_33 PF13671.6 EMD59013.1 - 0.00012 22.3 0.5 0.061 13.5 0.0 3.2 4 1 0 4 4 4 2 AAA domain AAA_18 PF13238.6 EMD59013.1 - 0.0016 19.0 0.4 0.12 12.9 0.4 2.9 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EMD59013.1 - 0.03 14.7 0.0 0.083 13.3 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain Cytidylate_kin PF02224.18 EMD59013.1 - 0.037 13.8 0.1 0.14 11.9 0.0 2.0 2 0 0 2 2 2 0 Cytidylate kinase zf-C2H2_jaz PF12171.8 EMD59013.1 - 0.037 14.3 0.0 0.063 13.6 0.0 1.4 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding Rpr2 PF04032.16 EMD59013.1 - 0.039 14.2 0.0 0.087 13.1 0.0 1.5 1 0 0 1 1 1 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain DUF87 PF01935.17 EMD59013.1 - 0.14 12.2 1.1 0.99 9.4 0.0 2.6 3 0 0 3 3 3 0 Helicase HerA, central domain DUF3328 PF11807.8 EMD59014.1 - 9.3e-25 87.7 0.0 1.1e-24 87.4 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) Mei4 PF13971.6 EMD59015.1 - 0.0001 21.9 3.1 0.00075 19.1 2.2 2.5 1 1 0 1 1 1 1 Meiosis-specific protein Mei4 KASH_CCD PF14662.6 EMD59015.1 - 0.051 13.4 0.0 0.1 12.4 0.0 1.4 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH PBP PF01161.20 EMD59016.1 - 2.2e-09 37.7 0.0 3.8e-09 36.9 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein Ribosomal_L4 PF00573.22 EMD59017.1 - 2.9e-47 160.9 0.1 7.9e-47 159.4 0.0 1.7 2 0 0 2 2 2 1 Ribosomal protein L4/L1 family TPR_14 PF13428.6 EMD59017.1 - 2.8 9.0 7.1 0.62 11.0 2.2 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat IF3_N PF05198.16 EMD59018.1 - 7.5e-06 26.1 0.0 1.3e-05 25.3 0.0 1.4 1 0 0 1 1 1 1 Translation initiation factor IF-3, N-terminal domain IF3_C PF00707.22 EMD59018.1 - 2.8e-05 24.0 0.1 8.8e-05 22.4 0.0 1.8 1 1 1 2 2 2 1 Translation initiation factor IF-3, C-terminal domain mIF3 PF14877.6 EMD59018.1 - 0.027 14.1 0.0 0.051 13.3 0.0 1.5 1 1 0 1 1 1 0 Mitochondrial translation initiation factor ATG16 PF08614.11 EMD59019.1 - 2.4e-50 171.5 22.2 2.8e-50 171.4 22.2 1.0 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) Golgin_A5 PF09787.9 EMD59019.1 - 0.0065 16.0 10.4 0.0086 15.6 10.4 1.1 1 0 0 1 1 1 1 Golgin subfamily A member 5 FlaC_arch PF05377.11 EMD59019.1 - 0.012 16.0 8.1 1.5 9.3 0.1 2.6 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) CENP-F_leu_zip PF10473.9 EMD59019.1 - 0.013 15.5 21.8 0.033 14.2 2.6 2.2 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DivIC PF04977.15 EMD59019.1 - 0.03 14.1 16.6 0.13 12.0 3.7 3.1 2 1 1 3 3 3 0 Septum formation initiator Rootletin PF15035.6 EMD59019.1 - 0.033 14.2 14.0 0.045 13.8 14.0 1.2 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion DUF4201 PF13870.6 EMD59019.1 - 0.047 13.4 16.1 0.11 12.2 15.6 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4201) DUF4407 PF14362.6 EMD59019.1 - 0.063 12.6 13.8 0.093 12.1 13.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) APG6_N PF17675.1 EMD59019.1 - 0.083 13.4 24.9 0.098 13.2 6.4 2.5 1 1 1 2 2 2 0 Apg6 coiled-coil region GAS PF13851.6 EMD59019.1 - 0.086 12.2 17.4 0.033 13.5 3.0 2.0 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding LMWPc PF01451.21 EMD59019.1 - 0.13 12.6 1.3 0.18 12.2 0.6 1.7 2 1 0 2 2 1 0 Low molecular weight phosphotyrosine protein phosphatase SlyX PF04102.12 EMD59019.1 - 0.16 12.6 14.6 0.08 13.6 3.5 2.9 1 1 2 3 3 3 0 SlyX DHR10 PF18595.1 EMD59019.1 - 0.23 11.5 21.1 11 6.1 19.7 3.0 2 1 0 2 2 2 0 Designed helical repeat protein 10 domain UPF0242 PF06785.11 EMD59019.1 - 0.66 10.0 14.9 0.32 11.1 1.4 2.1 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Syntaxin-6_N PF09177.11 EMD59019.1 - 0.69 10.5 12.2 1.4 9.5 2.4 2.3 1 1 1 2 2 2 0 Syntaxin 6, N-terminal Spc7 PF08317.11 EMD59019.1 - 0.92 8.3 16.5 1.8 7.3 16.3 1.5 1 1 0 1 1 1 0 Spc7 kinetochore protein YabA PF06156.13 EMD59019.1 - 0.98 10.1 15.0 1.9 9.2 6.9 2.2 1 1 1 2 2 2 0 Initiation control protein YabA Fib_alpha PF08702.10 EMD59019.1 - 1.4 9.1 7.5 2.3 8.4 0.2 2.3 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DUF3450 PF11932.8 EMD59019.1 - 2.2 7.5 17.8 1.8 7.8 5.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) TMF_TATA_bd PF12325.8 EMD59019.1 - 3.5 7.9 19.6 4.3 7.6 6.6 2.2 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding LMBR1 PF04791.16 EMD59019.1 - 4 6.2 5.8 4.6 6.0 5.8 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein ZapB PF06005.12 EMD59019.1 - 4.7 7.7 20.7 0.14 12.6 2.8 2.6 1 1 2 3 3 3 0 Cell division protein ZapB TMF_DNA_bd PF12329.8 EMD59019.1 - 8.5 6.5 20.2 0.15 12.1 0.5 3.0 1 1 2 3 3 3 0 TATA element modulatory factor 1 DNA binding JAB PF01398.21 EMD59020.1 - 2.8e-30 104.7 0.2 6e-30 103.6 0.1 1.6 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease CSN5_C PF18323.1 EMD59020.1 - 1e-18 68.0 0.7 2.6e-18 66.7 0.7 1.7 1 0 0 1 1 1 1 Cop9 signalosome subunit 5 C-terminal domain Prok-JAB PF14464.6 EMD59020.1 - 8.6e-07 28.7 0.0 1.4e-06 28.1 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain UPF0172 PF03665.13 EMD59020.1 - 0.0079 16.3 0.0 0.013 15.6 0.0 1.5 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0172) tRNA-synt_1c PF00749.21 EMD59021.1 - 1.2e-93 313.4 0.0 1.7e-93 313.0 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain DnaJ_C PF01556.18 EMD59022.1 - 6.1e-38 130.2 0.2 9.3e-38 129.6 0.2 1.3 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EMD59022.1 - 3.6e-21 75.1 4.5 6.2e-21 74.3 4.5 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 EMD59022.1 - 2e-13 50.5 19.1 3.8e-13 49.6 19.1 1.5 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 EMD59022.1 - 0.0012 18.8 16.8 0.0013 18.6 3.5 2.7 1 1 1 2 2 2 2 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.19 EMD59022.1 - 1.8 8.6 6.9 3.4 7.7 0.9 2.6 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF1356 PF07092.12 EMD59022.1 - 5.9 6.1 6.6 8.3 5.6 2.3 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1356) DUF3623 PF12291.8 EMD59024.1 - 0.089 12.0 3.4 0.13 11.4 3.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3623) DUF2207 PF09972.9 EMD59024.1 - 0.12 11.1 1.2 0.13 11.0 1.2 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF2157 PF09925.9 EMD59024.1 - 0.16 11.7 4.7 0.25 11.1 4.7 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2157) DUF4131 PF13567.6 EMD59024.1 - 1.7 8.2 4.6 2.6 7.7 4.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) DUF983 PF06170.12 EMD59024.1 - 4.8 7.7 8.8 5.3 7.5 7.9 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF983) CorA PF01544.18 EMD59025.1 - 3.1e-06 26.7 0.1 4.9e-06 26.1 0.1 1.2 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein HhH-GPD PF00730.25 EMD59026.1 - 0.0059 17.0 0.0 0.0074 16.7 0.0 1.2 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein ATG22 PF11700.8 EMD59027.1 - 3e-169 563.6 11.4 3.5e-169 563.5 11.4 1.0 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like B12D PF06522.11 EMD59027.1 - 2.6 7.9 8.9 0.69 9.7 1.6 3.0 3 0 0 3 3 3 0 NADH-ubiquinone reductase complex 1 MLRQ subunit MFAP1 PF06991.11 EMD59028.1 - 3.2e-67 226.6 27.0 3.2e-67 226.6 27.0 2.3 1 1 1 2 2 2 1 Microfibril-associated/Pre-mRNA processing Serglycin PF04360.12 EMD59028.1 - 0.0025 17.8 3.0 0.0047 16.9 3.0 1.4 1 0 0 1 1 1 1 Serglycin Y2_Tnp PF04986.13 EMD59028.1 - 0.099 12.7 3.5 0.32 11.0 0.5 2.2 2 0 0 2 2 2 0 Putative transposase Cwf_Cwc_15 PF04889.12 EMD59028.1 - 0.49 10.1 43.8 0.084 12.6 24.7 2.8 1 1 2 3 3 3 0 Cwf15/Cwc15 cell cycle control protein Cyclin PF08613.11 EMD59030.1 - 6.1e-14 52.7 0.0 1.3e-13 51.7 0.0 1.6 1 1 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 EMD59030.1 - 0.0012 18.6 0.0 0.0019 17.9 0.0 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Ribosomal_L27A PF00828.19 EMD59033.1 - 1.7e-32 112.8 0.3 2.7e-32 112.1 0.3 1.3 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A GDPD PF03009.17 EMD59035.1 - 1.1e-19 71.2 0.0 1.4e-19 70.8 0.0 1.4 1 1 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family DUF4858 PF16150.5 EMD59036.1 - 0.18 11.9 0.0 0.29 11.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4858) Zn_clus PF00172.18 EMD59038.1 - 2.7e-08 33.8 7.0 4.9e-08 33.0 7.0 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EMD59038.1 - 7.5e-06 25.2 0.0 1.2e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain HOOK PF05622.12 EMD59038.1 - 0.044 12.0 0.1 0.062 11.4 0.1 1.1 1 0 0 1 1 1 0 HOOK protein DUF87 PF01935.17 EMD59039.1 - 0.00012 22.3 0.1 0.07 13.2 0.0 2.4 3 0 0 3 3 3 2 Helicase HerA, central domain AAA_22 PF13401.6 EMD59039.1 - 0.00078 19.7 0.0 0.1 12.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 EMD59039.1 - 0.0046 16.3 0.0 0.009 15.3 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin FtsK_SpoIIIE PF01580.18 EMD59039.1 - 0.012 15.0 0.0 0.061 12.7 0.0 2.0 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_16 PF13191.6 EMD59039.1 - 0.021 15.2 0.0 0.13 12.7 0.0 2.3 1 1 0 1 1 1 0 AAA ATPase domain DUF853 PF05872.12 EMD59039.1 - 0.087 11.4 0.0 0.28 9.7 0.0 1.7 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF853) Microtub_bd PF16796.5 EMD59039.1 - 0.18 11.7 0.1 0.59 10.1 0.0 1.8 2 0 0 2 2 2 0 Microtubule binding Ribonucleas_3_3 PF14622.6 EMD59040.1 - 2.3e-06 27.8 0.0 3.3e-06 27.3 0.0 1.2 1 0 0 1 1 1 1 Ribonuclease-III-like Ribonuclease_3 PF00636.26 EMD59040.1 - 0.018 15.7 0.1 0.057 14.1 0.1 1.8 1 1 0 1 1 1 0 Ribonuclease III domain Lactonase PF10282.9 EMD59041.1 - 7.4e-26 91.2 0.4 1.9e-25 89.9 0.3 1.6 2 0 0 2 2 2 1 Lactonase, 7-bladed beta-propeller MmgE_PrpD PF03972.14 EMD59042.1 - 6.1e-114 380.9 1.5 7.4e-114 380.7 1.5 1.0 1 0 0 1 1 1 1 MmgE/PrpD family Fungal_trans PF04082.18 EMD59043.1 - 3.2e-25 88.7 0.3 6.7e-25 87.6 0.3 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD59043.1 - 2e-07 31.0 6.9 3.7e-07 30.2 6.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain adh_short_C2 PF13561.6 EMD59044.1 - 7.7e-59 199.1 0.2 1.1e-58 198.6 0.2 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EMD59044.1 - 6.3e-46 156.3 0.9 9.5e-46 155.7 0.9 1.3 1 0 0 1 1 1 1 short chain dehydrogenase DLH PF01738.18 EMD59044.1 - 2e-17 63.5 0.0 3.1e-17 62.9 0.0 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family KR PF08659.10 EMD59044.1 - 0.015 15.3 0.1 0.026 14.5 0.1 1.3 1 0 0 1 1 1 0 KR domain Peptidase_S9 PF00326.21 EMD59044.1 - 0.023 14.2 0.0 0.046 13.2 0.0 1.4 1 0 0 1 1 1 0 Prolyl oligopeptidase family 3HCDH_N PF02737.18 EMD59044.1 - 0.079 12.8 0.3 0.24 11.3 0.1 1.8 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain MFS_1 PF07690.16 EMD59045.1 - 5.4e-31 107.8 27.9 7e-31 107.4 27.9 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_1_like PF12832.7 EMD59045.1 - 0.00034 19.6 16.1 0.00069 18.6 14.3 1.8 1 1 1 2 2 2 1 MFS_1 like family Fasciclin PF02469.22 EMD59046.1 - 7e-31 107.1 0.0 2.7e-16 59.9 0.0 2.3 2 0 0 2 2 2 2 Fasciclin domain IDO PF01231.18 EMD59047.1 - 6.9e-41 140.4 0.0 1.7e-40 139.2 0.0 1.6 2 0 0 2 2 2 1 Indoleamine 2,3-dioxygenase GTP_EFTU PF00009.27 EMD59047.1 - 6.3e-18 65.0 0.0 1.1e-17 64.2 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 EMD59047.1 - 8.2e-10 38.9 2.1 3.9e-09 36.8 1.5 2.5 2 0 0 2 2 2 1 Elongation factor Tu domain 2 GTP_EFTU_D3 PF03143.17 EMD59047.1 - 0.00013 22.2 0.0 0.00031 21.0 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain PduV-EutP PF10662.9 EMD59047.1 - 0.049 13.4 0.5 1.9 8.2 0.1 3.1 2 1 1 3 3 3 0 Ethanolamine utilisation - propanediol utilisation RsgA_GTPase PF03193.16 EMD59047.1 - 0.1 12.5 0.2 5.4 6.9 0.0 2.5 2 0 0 2 2 2 0 RsgA GTPase MMR_HSR1 PF01926.23 EMD59047.1 - 0.11 12.6 0.1 0.11 12.6 0.1 2.2 2 1 0 2 2 2 0 50S ribosome-binding GTPase Fmp27 PF10344.9 EMD59048.1 - 1.1e-207 692.1 0.0 1.6e-207 691.6 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial protein from FMP27 Apt1 PF10351.9 EMD59048.1 - 1.7e-183 610.9 2.8 1.7e-183 610.9 2.8 2.8 3 0 0 3 3 3 1 Golgi-body localisation protein domain Fmp27_WPPW PF10359.9 EMD59048.1 - 1.8e-169 564.7 5.7 3.8e-169 563.6 5.7 1.6 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain Fmp27_GFWDK PF10347.9 EMD59048.1 - 8.4e-60 201.4 0.0 1.9e-59 200.2 0.0 1.7 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain DUF2405 PF10293.9 EMD59048.1 - 2.2e-56 190.0 0.4 5e-56 188.9 0.4 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF2405) Fmp27_SW PF10305.9 EMD59048.1 - 1.7e-29 102.6 0.8 5.1e-29 101.0 0.0 2.4 2 0 0 2 2 2 1 RNA pol II promoter Fmp27 protein domain Polysacc_deac_1 PF01522.21 EMD59050.1 - 3.5e-15 56.0 0.0 8.3e-15 54.8 0.0 1.6 1 0 0 1 1 1 1 Polysaccharide deacetylase NTP_transf_9 PF04248.12 EMD59052.1 - 1.9e-39 133.4 1.0 1.3e-32 111.5 0.3 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF427) Fringe PF02434.16 EMD59053.1 - 6.7e-09 35.5 0.0 4.2e-08 32.9 0.0 1.9 1 1 0 1 1 1 1 Fringe-like PAN_4 PF14295.6 EMD59053.1 - 0.02 14.8 2.4 0.044 13.7 2.4 1.5 1 0 0 1 1 1 0 PAN domain PAN_3 PF08277.12 EMD59053.1 - 0.055 13.3 0.6 0.12 12.2 0.1 1.8 2 0 0 2 2 2 0 PAN-like domain Galactosyl_T PF01762.21 EMD59053.1 - 0.12 12.1 0.0 0.24 11.2 0.0 1.5 1 0 0 1 1 1 0 Galactosyltransferase GH131_N PF18271.1 EMD59054.1 - 7.8e-75 251.9 0.1 8.9e-75 251.7 0.1 1.0 1 0 0 1 1 1 1 Glycoside hydrolase 131 catalytic N-terminal domain ABC_tran PF00005.27 EMD59055.1 - 7.3e-16 58.9 0.0 7.1e-15 55.7 0.0 2.1 1 1 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 EMD59055.1 - 2.2e-11 44.1 1.2 0.00012 22.0 0.1 2.1 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EMD59055.1 - 0.0002 20.9 0.0 0.082 12.3 0.0 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EMD59055.1 - 0.00086 19.0 0.8 0.003 17.2 0.1 2.0 2 0 0 2 2 2 1 P-loop containing region of AAA domain DUF3584 PF12128.8 EMD59055.1 - 0.0019 15.8 0.0 0.0025 15.4 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) FtsK_SpoIIIE PF01580.18 EMD59055.1 - 0.0039 16.6 0.0 0.0052 16.2 0.0 1.3 1 0 0 1 1 1 1 FtsK/SpoIIIE family AAA_23 PF13476.6 EMD59055.1 - 0.0051 17.3 0.1 0.0093 16.5 0.1 1.3 1 0 0 1 1 1 1 AAA domain PduV-EutP PF10662.9 EMD59055.1 - 0.0085 15.8 0.0 0.013 15.2 0.0 1.3 1 0 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation AAA_15 PF13175.6 EMD59055.1 - 0.013 15.3 0.0 0.019 14.7 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain AAA_25 PF13481.6 EMD59055.1 - 0.024 14.2 0.1 0.04 13.5 0.1 1.4 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 EMD59055.1 - 0.024 14.9 0.2 0.042 14.1 0.2 1.4 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 EMD59055.1 - 0.026 14.9 0.0 0.16 12.4 0.0 2.2 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) SRP54 PF00448.22 EMD59055.1 - 0.031 13.9 0.1 0.051 13.2 0.1 1.2 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain RsgA_GTPase PF03193.16 EMD59055.1 - 0.054 13.4 0.0 0.087 12.7 0.0 1.3 1 0 0 1 1 1 0 RsgA GTPase AAA_16 PF13191.6 EMD59055.1 - 0.067 13.6 0.5 0.23 11.8 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain Zeta_toxin PF06414.12 EMD59055.1 - 0.094 12.0 0.0 0.15 11.3 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin AAA_22 PF13401.6 EMD59055.1 - 0.12 12.7 0.4 0.46 10.7 0.1 2.0 2 0 0 2 2 2 0 AAA domain AAA_13 PF13166.6 EMD59055.1 - 0.12 11.0 0.0 0.17 10.5 0.0 1.1 1 0 0 1 1 1 0 AAA domain Arf PF00025.21 EMD59055.1 - 0.12 11.8 0.3 0.27 10.7 0.0 1.6 2 0 0 2 2 2 0 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EMD59055.1 - 0.15 12.1 0.1 0.3 11.2 0.1 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase Roc PF08477.13 EMD59055.1 - 0.17 12.1 0.0 0.39 10.9 0.0 1.6 2 0 0 2 2 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_33 PF13671.6 EMD59055.1 - 0.17 12.0 0.0 0.31 11.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain F-box PF00646.33 EMD59056.1 - 0.004 17.0 0.0 0.011 15.7 0.0 1.7 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EMD59056.1 - 0.048 13.6 0.1 0.25 11.3 0.0 2.3 3 0 0 3 3 3 0 F-box-like ADH_N PF08240.12 EMD59057.1 - 1.1e-25 89.6 4.5 3.3e-25 88.1 2.8 2.3 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EMD59057.1 - 3.1e-25 88.6 0.3 4.9e-25 88.0 0.3 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EMD59057.1 - 1.2e-06 29.6 0.0 2.6e-06 28.5 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase adh_short PF00106.25 EMD59057.1 - 0.04 13.4 1.3 0.065 12.7 1.3 1.4 1 0 0 1 1 1 0 short chain dehydrogenase PKcGMP_CC PF16808.5 EMD59059.1 - 0.00051 19.8 4.7 0.0011 18.8 1.2 2.7 2 0 0 2 2 2 1 Coiled-coil N-terminus of cGMP-dependent protein kinase Lzipper-MIP1 PF14389.6 EMD59059.1 - 0.0015 18.8 8.7 0.057 13.7 1.3 3.1 3 0 0 3 3 3 2 Leucine-zipper of ternary complex factor MIP1 DUF4472 PF14739.6 EMD59059.1 - 0.037 14.8 46.0 0.12 13.1 7.9 4.3 1 1 2 4 4 4 0 Domain of unknown function (DUF4472) DUF4720 PF15846.5 EMD59059.1 - 0.47 10.3 3.5 11 6.0 0.0 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4720) FlaC_arch PF05377.11 EMD59059.1 - 0.79 10.2 0.1 0.79 10.2 0.1 3.7 4 0 0 4 4 4 0 Flagella accessory protein C (FlaC) TSC22 PF01166.18 EMD59059.1 - 8.3 6.8 9.2 26 5.2 0.1 4.0 4 0 0 4 4 4 0 TSC-22/dip/bun family ATG22 PF11700.8 EMD59060.1 - 1e-136 456.3 25.4 1.2e-136 456.1 25.4 1.0 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like MFS_1 PF07690.16 EMD59060.1 - 2.5e-14 53.0 26.2 1.8e-08 33.7 2.3 3.1 2 1 1 3 3 3 3 Major Facilitator Superfamily p450 PF00067.22 EMD59061.1 - 4.5e-29 101.5 1.0 2.9e-27 95.5 0.5 2.3 1 1 1 2 2 2 2 Cytochrome P450 Pkinase PF00069.25 EMD59062.1 - 0.00013 21.5 0.0 0.00055 19.4 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain APH PF01636.23 EMD59062.1 - 0.0011 19.0 0.0 0.002 18.1 0.0 1.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EMD59062.1 - 0.0083 14.9 0.2 0.012 14.4 0.2 1.1 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EMD59062.1 - 0.036 13.4 0.0 0.054 12.8 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 EMD59062.1 - 0.038 13.6 0.0 0.06 12.9 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase EcKinase PF02958.20 EMD59062.1 - 0.14 11.5 0.0 0.28 10.5 0.0 1.4 2 0 0 2 2 2 0 Ecdysteroid kinase F-box-like PF12937.7 EMD59063.1 - 0.00014 21.7 2.5 0.0002 21.1 0.5 2.4 3 0 0 3 3 3 1 F-box-like Tyr-DNA_phospho PF06087.12 EMD59064.1 - 1.5e-84 284.4 0.0 2e-84 284.0 0.0 1.1 1 0 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase UIM PF02809.20 EMD59064.1 - 4.3e-05 23.1 0.2 4.3e-05 23.1 0.2 3.0 3 0 0 3 3 3 1 Ubiquitin interaction motif PLDc_2 PF13091.6 EMD59064.1 - 4.8e-05 23.3 0.0 0.004 17.0 0.0 2.4 2 0 0 2 2 2 2 PLD-like domain Urm1 PF09138.11 EMD59065.1 - 2.5e-34 117.5 0.0 2.8e-34 117.3 0.0 1.0 1 0 0 1 1 1 1 Urm1 (Ubiquitin related modifier) ThiS PF02597.20 EMD59065.1 - 0.0068 17.0 0.0 0.0082 16.8 0.0 1.2 1 0 0 1 1 1 1 ThiS family WD40 PF00400.32 EMD59066.1 - 2.2e-38 129.6 32.8 1e-05 26.2 0.1 12.5 12 1 0 12 12 12 8 WD domain, G-beta repeat BBS2_Mid PF14783.6 EMD59066.1 - 4.8e-07 29.8 0.1 0.03 14.4 0.0 5.2 6 0 0 6 6 6 2 Ciliary BBSome complex subunit 2, middle region ANAPC4_WD40 PF12894.7 EMD59066.1 - 9.5e-07 29.0 2.8 2.9 8.2 0.0 7.6 6 3 3 9 9 9 1 Anaphase-promoting complex subunit 4 WD40 domain DUF273 PF03314.14 EMD59066.1 - 0.14 11.7 0.0 0.31 10.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF273 PD40 PF07676.12 EMD59066.1 - 0.5 10.4 6.5 6.7 6.8 0.1 4.2 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat Bax1-I PF01027.20 EMD59067.1 - 0.085 12.7 5.1 0.035 13.9 2.7 1.5 2 0 0 2 2 2 0 Inhibitor of apoptosis-promoting Bax1 DUF3302 PF11742.8 EMD59067.1 - 0.12 12.5 0.0 0.12 12.5 0.0 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF3302) LapA_dom PF06305.11 EMD59067.1 - 5.5 6.9 5.9 25 4.8 0.1 3.1 3 0 0 3 3 3 0 Lipopolysaccharide assembly protein A domain UEV PF05743.13 EMD59068.1 - 1.5e-36 124.9 0.0 2.4e-36 124.3 0.0 1.3 1 0 0 1 1 1 1 UEV domain Vps23_core PF09454.10 EMD59068.1 - 1.2e-24 86.0 0.0 2.2e-24 85.2 0.0 1.4 1 0 0 1 1 1 1 Vps23 core domain Aminotran_5 PF00266.19 EMD59069.1 - 1.2e-94 317.3 0.0 1.5e-94 317.0 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 EMD59069.1 - 8.4e-06 25.3 0.0 1.2e-05 24.8 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 EMD59069.1 - 0.00035 20.0 0.2 0.0013 18.2 0.1 1.9 3 0 0 3 3 3 1 DegT/DnrJ/EryC1/StrS aminotransferase family BAR PF03114.18 EMD59070.1 - 3.6e-65 220.0 9.8 4.4e-65 219.7 9.8 1.1 1 0 0 1 1 1 1 BAR domain SH3_1 PF00018.28 EMD59070.1 - 2.4e-14 52.6 0.1 4.2e-14 51.9 0.1 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EMD59070.1 - 3.4e-11 42.8 0.1 5.8e-11 42.1 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EMD59070.1 - 1.5e-09 37.4 0.0 2.9e-09 36.5 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain NolV PF06635.12 EMD59070.1 - 0.047 13.1 0.0 0.08 12.3 0.0 1.3 1 0 0 1 1 1 0 Nodulation protein NolV Radial_spoke_3 PF06098.11 EMD59070.1 - 0.34 10.2 9.1 0.12 11.6 3.1 2.2 2 0 0 2 2 2 0 Radial spoke protein 3 BAR_3 PF16746.5 EMD59070.1 - 0.68 9.6 10.8 2.5 7.7 10.8 1.9 1 1 0 1 1 1 0 BAR domain of APPL family TMPIT PF07851.13 EMD59070.1 - 1.4 8.1 6.7 0.38 10.0 0.2 2.1 1 1 1 2 2 2 0 TMPIT-like protein Vps5 PF09325.10 EMD59070.1 - 2.9 7.4 10.3 52 3.3 10.3 2.2 1 1 0 1 1 1 0 Vps5 C terminal like DSBA PF01323.20 EMD59071.1 - 1e-19 71.1 0.0 1.1e-19 70.9 0.0 1.0 1 0 0 1 1 1 1 DSBA-like thioredoxin domain GTP_cyclohydro2 PF00925.20 EMD59073.1 - 5e-57 192.0 0.0 1.3e-56 190.7 0.0 1.6 1 1 0 1 1 1 1 GTP cyclohydrolase II WD40 PF00400.32 EMD59074.1 - 1.1e-86 282.4 57.7 6.3e-12 45.8 1.0 9.2 9 0 0 9 9 9 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD59074.1 - 1.1e-27 96.2 17.8 0.0003 21.0 0.1 8.8 1 1 7 8 8 8 8 Anaphase-promoting complex subunit 4 WD40 domain NACHT PF05729.12 EMD59074.1 - 4.2e-20 72.3 0.1 8e-20 71.4 0.1 1.4 1 0 0 1 1 1 1 NACHT domain Nup160 PF11715.8 EMD59074.1 - 3.5e-17 62.2 28.1 0.0078 14.9 0.1 8.1 1 1 7 8 8 8 8 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 EMD59074.1 - 3.8e-15 55.7 29.6 0.00058 18.9 2.6 6.5 1 1 6 7 7 7 7 WD40 region of Ge1, enhancer of mRNA-decapping protein HET PF06985.11 EMD59074.1 - 1.5e-12 48.1 7.4 5e-11 43.1 0.0 3.1 2 1 1 3 3 3 2 Heterokaryon incompatibility protein (HET) CDtoxinA PF03498.14 EMD59074.1 - 0.0021 17.7 0.0 5.6 6.5 0.0 4.0 1 1 4 5 5 5 1 Cytolethal distending toxin A/C domain AAA_19 PF13245.6 EMD59074.1 - 0.2 12.0 0.0 0.54 10.6 0.0 1.7 2 0 0 2 2 2 0 AAA domain Cytochrom_D1 PF02239.16 EMD59074.1 - 0.29 9.6 5.6 2.8 6.4 0.2 3.0 1 1 1 3 3 3 0 Cytochrome D1 heme domain Sugar_tr PF00083.24 EMD59076.1 - 4.2e-84 283.0 8.9 6e-84 282.5 8.9 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD59076.1 - 2.2e-29 102.5 35.4 1.8e-22 79.8 15.1 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 EMD59076.1 - 4.7e-07 29.4 4.9 4.7e-07 29.4 4.9 2.7 2 1 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB TRI12 PF06609.13 EMD59076.1 - 0.00044 18.8 2.3 0.00044 18.8 2.3 2.0 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Pkinase PF00069.25 EMD59077.1 - 5.1e-65 219.4 0.0 6.5e-65 219.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD59077.1 - 3.3e-31 108.5 0.0 1.5e-30 106.3 0.0 1.8 1 1 1 2 2 2 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EMD59077.1 - 0.00017 20.7 0.0 0.00023 20.2 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EMD59077.1 - 0.012 15.5 0.0 0.23 11.4 0.0 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family FTA2 PF13095.6 EMD59077.1 - 0.024 14.2 0.1 2.8 7.5 0.0 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 CBF PF03914.17 EMD59077.1 - 0.066 13.2 0.0 0.68 9.9 0.0 2.4 3 0 0 3 3 3 0 CBF/Mak21 family CAP PF00188.26 EMD59078.1 - 2.8e-19 70.2 1.5 3.9e-19 69.7 1.5 1.2 1 0 0 1 1 1 1 Cysteine-rich secretory protein family Heme_oxygenase PF01126.20 EMD59079.1 - 5.2e-11 42.7 0.0 5.5e-10 39.4 0.0 2.1 2 0 0 2 2 2 1 Heme oxygenase PNP_UDP_1 PF01048.20 EMD59080.1 - 3.1e-06 26.6 2.1 3.2e-05 23.3 2.1 2.2 1 1 0 1 1 1 1 Phosphorylase superfamily UBA_3 PF09288.10 EMD59080.1 - 0.041 13.7 0.0 0.097 12.5 0.0 1.5 1 0 0 1 1 1 0 Fungal ubiquitin-associated domain CorA PF01544.18 EMD59081.1 - 2.8e-07 30.2 1.2 3.6e-07 29.8 1.2 1.2 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein NACHT PF05729.12 EMD59083.1 - 1.4e-09 38.1 0.0 3e-09 37.0 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 EMD59083.1 - 4.8e-07 30.3 0.5 1.1e-06 29.1 0.2 1.8 2 0 0 2 2 2 1 AAA ATPase domain APS_kinase PF01583.20 EMD59083.1 - 0.0032 17.4 0.0 0.0059 16.5 0.0 1.4 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_18 PF13238.6 EMD59083.1 - 0.019 15.5 0.4 0.25 11.9 0.1 2.7 2 1 0 2 2 2 0 AAA domain AAA PF00004.29 EMD59083.1 - 0.028 14.9 0.1 0.14 12.6 0.1 2.2 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 EMD59083.1 - 0.091 12.5 0.0 0.18 11.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 EMD59083.1 - 0.11 11.7 0.0 0.28 10.3 0.0 1.6 2 0 0 2 2 2 0 NB-ARC domain AAA_22 PF13401.6 EMD59083.1 - 0.15 12.4 0.1 0.56 10.5 0.0 2.1 2 1 0 2 2 2 0 AAA domain WD40 PF00400.32 EMD59084.1 - 3.3e-49 163.8 6.4 2.5e-10 40.8 0.2 5.3 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD59084.1 - 5.8e-18 65.0 0.2 0.00059 20.1 0.0 4.3 1 1 3 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EMD59084.1 - 4.4e-16 58.8 0.7 0.0062 15.5 0.0 4.9 1 1 4 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Proteasome_A_N PF10584.9 EMD59084.1 - 3.9e-11 42.4 0.2 4.1 7.2 0.0 6.1 6 0 0 6 6 6 4 Proteasome subunit A N-terminal signature PD40 PF07676.12 EMD59084.1 - 4.9e-09 35.9 0.0 1.1 9.3 0.0 5.3 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat Nup160 PF11715.8 EMD59084.1 - 5.3e-09 35.3 7.6 0.045 12.4 0.0 4.0 1 1 3 4 4 4 3 Nucleoporin Nup120/160 Stimulus_sens_1 PF13756.6 EMD59084.1 - 3.2e-08 34.2 0.0 6.8 7.3 0.0 4.5 4 0 0 4 4 4 1 Stimulus-sensing domain Robl_LC7 PF03259.17 EMD59084.1 - 4.3e-08 32.8 0.5 3.8 7.4 0.0 4.2 3 1 1 4 4 4 3 Roadblock/LC7 domain eIF2A PF08662.11 EMD59084.1 - 7.5e-07 29.2 0.0 0.027 14.4 0.0 2.6 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A IKI3 PF04762.12 EMD59084.1 - 9.8e-07 27.2 0.2 0.1 10.5 0.0 3.0 1 1 2 3 3 3 3 IKI3 family SMP_2 PF10144.9 EMD59084.1 - 1.7e-06 27.7 0.0 1.9 8.1 0.0 4.0 1 1 3 4 4 4 1 Bacterial virulence factor haemolysin DUF3261 PF11659.8 EMD59084.1 - 1.2e-05 25.2 0.2 0.57 10.0 0.1 3.7 1 1 2 3 3 3 2 Protein of unknown function (DUF3261) Ret2_MD PF18528.1 EMD59084.1 - 0.00012 22.4 0.0 6.9 7.1 0.0 4.3 1 1 4 5 5 5 1 RNA editing 3' terminal uridylyl transferase 2 middle domain TruB_C PF09142.11 EMD59084.1 - 0.00015 21.5 1.4 12 5.7 0.0 4.9 5 0 0 5 5 5 0 tRNA Pseudouridine synthase II, C terminal DUF4189 PF13827.6 EMD59084.1 - 0.00018 22.0 0.5 2.2 8.9 0.0 3.5 1 1 3 4 4 4 2 Domain of unknown function (DUF4189) Coatomer_WDAD PF04053.14 EMD59084.1 - 0.00057 19.1 0.1 2.4 7.1 0.0 3.5 1 1 2 3 3 3 1 Coatomer WD associated region NodS PF05401.11 EMD59084.1 - 0.00091 18.9 1.4 5.6 6.5 0.0 3.9 1 1 3 4 4 4 1 Nodulation protein S (NodS) SRF-TF PF00319.18 EMD59084.1 - 0.0017 17.8 0.2 47 3.6 0.0 4.6 5 0 0 5 5 5 0 SRF-type transcription factor (DNA-binding and dimerisation domain) PDT PF00800.18 EMD59084.1 - 0.0033 17.3 0.4 39 4.0 0.0 4.3 1 1 4 5 5 5 0 Prephenate dehydratase DUF3761 PF12587.8 EMD59084.1 - 0.0087 16.5 0.7 52 4.4 0.0 3.7 1 1 3 4 4 4 0 Protein of unknown function (DUF3761) Defensin_RK-1 PF17860.1 EMD59084.1 - 0.018 15.5 0.0 79 3.8 0.0 3.4 3 0 0 3 3 3 0 RK-1-like defensin Cytochrom_D1 PF02239.16 EMD59084.1 - 0.021 13.4 0.4 3.5 6.0 0.1 2.3 1 1 1 2 2 2 0 Cytochrome D1 heme domain PRTase_2 PF15609.6 EMD59084.1 - 0.037 13.5 0.3 4.5 6.7 0.1 2.9 1 1 2 3 3 3 0 Phosphoribosyl transferase WD40_like PF17005.5 EMD59084.1 - 0.15 11.4 0.0 9.4 5.5 0.0 2.7 1 1 1 3 3 3 0 WD40-like domain dCache_1 PF02743.18 EMD59084.1 - 0.15 11.8 0.0 74 3.0 0.0 3.5 1 1 1 3 3 3 0 Cache domain Peptidase_S9_N PF02897.15 EMD59084.1 - 0.16 10.8 0.1 18 4.0 0.0 3.4 3 1 1 4 4 4 0 Prolyl oligopeptidase, N-terminal beta-propeller domain zf-C2H2 PF00096.26 EMD59085.1 - 2.6e-05 24.4 24.1 0.022 15.2 0.1 4.4 4 1 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMD59085.1 - 0.023 15.5 20.4 0.22 12.4 0.1 4.6 4 2 0 4 4 4 0 C2H2-type zinc finger IBR PF01485.21 EMD59085.1 - 0.15 12.3 7.1 2.8 8.2 0.2 2.9 1 1 2 3 3 3 0 IBR domain, a half RING-finger domain zf-BED PF02892.15 EMD59085.1 - 2.8 8.0 9.2 9.2 6.4 4.6 2.6 2 1 0 2 2 2 0 BED zinc finger UQ_con PF00179.26 EMD59086.1 - 4e-19 68.6 0.0 5.8e-19 68.1 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme COesterase PF00135.28 EMD59087.1 - 2.1e-87 294.2 0.0 2.7e-87 293.8 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EMD59087.1 - 0.00017 21.5 0.1 0.0016 18.3 0.1 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EMD59087.1 - 0.00025 20.6 0.1 0.0004 19.9 0.1 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family FA_desaturase PF00487.24 EMD59090.1 - 9e-27 94.5 23.6 1.4e-26 93.9 23.6 1.3 1 0 0 1 1 1 1 Fatty acid desaturase DUF3474 PF11960.8 EMD59090.1 - 6e-06 26.5 0.1 1.3e-05 25.4 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3474) RPE65 PF03055.15 EMD59091.1 - 1e-105 354.6 0.0 1.2e-105 354.4 0.0 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein DUF1254 PF06863.12 EMD59092.1 - 9.9e-29 100.1 0.3 2.8e-28 98.6 0.1 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF1254) DUF1214 PF06742.11 EMD59092.1 - 1e-24 87.1 0.0 2.1e-24 86.1 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1214) Zn_clus PF00172.18 EMD59095.1 - 1.6e-06 28.1 14.3 1.6e-06 28.1 14.3 2.3 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RR_TM4-6 PF06459.12 EMD59095.1 - 1.2 8.9 7.2 0.24 11.2 1.7 2.2 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Ctr PF04145.15 EMD59095.1 - 4.7 7.8 10.6 0.062 13.9 0.8 2.6 3 0 0 3 3 3 0 Ctr copper transporter family adh_short PF00106.25 EMD59096.1 - 1.8e-29 102.6 0.0 2.6e-29 102.1 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD59096.1 - 2.3e-22 79.7 0.0 3.5e-22 79.1 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 EMD59096.1 - 0.0033 16.9 0.0 0.008 15.7 0.0 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Eno-Rase_NADH_b PF12242.8 EMD59096.1 - 0.023 14.4 0.1 0.055 13.2 0.1 1.6 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase ACT_7 PF13840.6 EMD59096.1 - 0.035 13.9 0.1 0.066 13.0 0.1 1.4 1 0 0 1 1 1 0 ACT domain p450 PF00067.22 EMD59098.1 - 3.2e-64 217.4 0.0 4e-64 217.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 ABC_membrane PF00664.23 EMD59099.1 - 1.3e-93 313.6 36.1 4.9e-53 180.6 18.3 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EMD59099.1 - 1.6e-68 229.5 0.0 1.1e-33 116.6 0.0 2.6 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EMD59099.1 - 8.9e-14 51.4 0.0 0.0005 19.6 0.0 4.1 2 2 1 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EMD59099.1 - 6.1e-08 32.3 0.7 0.0096 15.6 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 EMD59099.1 - 6.5e-08 33.1 0.2 0.026 14.9 0.1 3.1 2 2 0 2 2 2 2 AAA ATPase domain AAA_15 PF13175.6 EMD59099.1 - 1.9e-07 31.1 0.1 0.0046 16.7 0.0 2.3 2 0 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 EMD59099.1 - 3.7e-06 27.0 0.2 0.078 12.9 0.0 3.3 3 0 0 3 3 3 2 RsgA GTPase ABC_ATPase PF09818.9 EMD59099.1 - 4e-06 25.9 3.8 0.055 12.3 0.4 3.4 4 0 0 4 4 4 2 Predicted ATPase of the ABC class AAA_30 PF13604.6 EMD59099.1 - 1.6e-05 24.8 0.1 0.053 13.2 0.0 3.7 3 1 0 3 3 3 1 AAA domain AAA_23 PF13476.6 EMD59099.1 - 6e-05 23.6 0.1 0.086 13.3 0.0 2.7 3 0 0 3 3 2 1 AAA domain AAA_22 PF13401.6 EMD59099.1 - 0.00023 21.5 1.4 0.87 9.9 0.2 3.8 2 2 0 2 2 2 2 AAA domain AAA_21 PF13304.6 EMD59099.1 - 0.00049 20.0 2.9 0.29 10.9 0.6 3.3 2 1 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system SbcCD_C PF13558.6 EMD59099.1 - 0.00062 19.9 2.0 2.9 8.2 0.2 4.0 2 2 0 2 2 2 2 Putative exonuclease SbcCD, C subunit AAA_5 PF07728.14 EMD59099.1 - 0.00064 19.7 0.1 1.7 8.7 0.0 3.6 4 0 0 4 4 3 1 AAA domain (dynein-related subfamily) PRK PF00485.18 EMD59099.1 - 0.00085 19.1 0.7 3.4 7.4 0.0 3.5 4 0 0 4 4 3 2 Phosphoribulokinase / Uridine kinase family Zeta_toxin PF06414.12 EMD59099.1 - 0.00091 18.5 0.0 0.41 9.9 0.0 2.7 2 0 0 2 2 2 1 Zeta toxin DUF87 PF01935.17 EMD59099.1 - 0.0016 18.6 0.3 0.96 9.5 0.1 2.8 3 0 0 3 3 2 1 Helicase HerA, central domain G-alpha PF00503.20 EMD59099.1 - 0.002 17.4 0.0 0.65 9.1 0.0 2.2 2 0 0 2 2 2 1 G-protein alpha subunit AAA_28 PF13521.6 EMD59099.1 - 0.0043 17.3 0.9 8.1 6.7 0.4 3.4 2 1 1 3 3 3 0 AAA domain AAA_25 PF13481.6 EMD59099.1 - 0.013 15.1 0.1 5.9 6.4 0.0 3.6 3 1 0 3 3 3 0 AAA domain RNA_helicase PF00910.22 EMD59099.1 - 0.016 15.6 0.0 11 6.5 0.0 2.7 2 0 0 2 2 2 0 RNA helicase AAA_7 PF12775.7 EMD59099.1 - 0.018 14.5 0.5 1.7 8.1 0.0 2.7 3 0 0 3 3 3 0 P-loop containing dynein motor region Dala_Dala_lig_N PF01820.21 EMD59099.1 - 0.026 15.0 0.0 1.9 9.0 0.0 2.6 2 0 0 2 2 2 0 D-ala D-ala ligase N-terminus AAA_18 PF13238.6 EMD59099.1 - 0.042 14.4 0.0 19 5.8 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 EMD59099.1 - 0.053 13.2 0.0 6.8 6.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 EMD59099.1 - 0.11 11.7 0.1 11 5.1 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain DUF815 PF05673.13 EMD59099.1 - 0.12 11.5 0.0 4.5 6.3 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_33 PF13671.6 EMD59099.1 - 0.13 12.4 0.1 24 5.1 0.0 2.8 3 0 0 3 3 2 0 AAA domain MMR_HSR1 PF01926.23 EMD59099.1 - 0.14 12.3 0.8 14 5.8 0.1 2.7 2 0 0 2 2 2 0 50S ribosome-binding GTPase Rad17 PF03215.15 EMD59099.1 - 0.14 12.0 0.0 3.2 7.6 0.0 2.4 2 0 0 2 2 2 0 Rad17 P-loop domain AMP-binding PF00501.28 EMD59100.1 - 3.9e-69 233.3 0.0 6.1e-69 232.6 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme Condensation PF00668.20 EMD59100.1 - 6.2e-27 94.4 0.0 1e-26 93.7 0.0 1.3 1 0 0 1 1 1 1 Condensation domain PP-binding PF00550.25 EMD59100.1 - 1e-08 35.4 0.1 2.4e-08 34.2 0.1 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site AMP-binding_C PF13193.6 EMD59100.1 - 1.4e-05 26.0 0.0 6.7e-05 23.8 0.0 2.3 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain DUF4537 PF15057.6 EMD59100.1 - 0.1 12.6 0.0 0.22 11.5 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4537) p450 PF00067.22 EMD59101.1 - 5.3e-55 187.0 0.0 2.5e-54 184.8 0.0 1.7 1 1 0 1 1 1 1 Cytochrome P450 DUF5056 PF16479.5 EMD59101.1 - 0.13 12.5 0.0 1 9.6 0.0 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF5056) 2OG-FeII_Oxy PF03171.20 EMD59102.1 - 1.5e-15 57.5 0.0 1.8e-14 54.0 0.0 2.2 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily TRI12 PF06609.13 EMD59103.1 - 5.9e-62 209.9 25.5 7.9e-62 209.5 25.5 1.0 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_1 PF07690.16 EMD59103.1 - 1.4e-18 66.9 49.3 1.5e-18 66.8 45.0 2.5 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EMD59103.1 - 2.3e-10 40.0 3.4 2.3e-10 40.0 3.4 2.5 2 0 0 2 2 2 2 Sugar (and other) transporter Pox_A14 PF05767.12 EMD59103.1 - 0.0057 16.8 0.2 0.032 14.4 0.0 2.4 2 0 0 2 2 2 1 Poxvirus virion envelope protein A14 TraA PF05513.11 EMD59103.1 - 0.094 13.1 2.6 2.7 8.4 0.2 3.3 2 1 1 3 3 3 0 TraA COesterase PF00135.28 EMD59104.1 - 1.3e-70 238.8 0.0 1.6e-70 238.5 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EMD59104.1 - 1.8e-05 24.7 0.1 5.7e-05 23.1 0.1 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 EMD59104.1 - 0.005 15.8 0.1 0.014 14.2 0.1 1.7 1 1 0 1 1 1 1 Steryl acetyl hydrolase p450 PF00067.22 EMD59105.1 - 3.7e-66 223.8 0.0 4.5e-66 223.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Pes-10 PF07149.11 EMD59105.1 - 0.055 12.5 0.5 0.081 12.0 0.5 1.1 1 0 0 1 1 1 0 Pes-10 Transferase PF02458.15 EMD59106.1 - 4.2e-29 101.5 0.0 5.6e-17 61.5 0.0 3.1 2 1 0 2 2 2 2 Transferase family NYN_YacP PF05991.11 EMD59106.1 - 0.049 13.6 0.0 0.075 13.0 0.0 1.2 1 0 0 1 1 1 0 YacP-like NYN domain p450 PF00067.22 EMD59107.1 - 3.7e-40 138.0 0.0 4.5e-40 137.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Cys_Met_Meta_PP PF01053.20 EMD59108.1 - 7.1e-123 409.9 0.0 1.4e-122 408.9 0.0 1.4 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 EMD59108.1 - 1.1e-12 47.8 0.0 2e-12 47.0 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 EMD59108.1 - 4.5e-10 39.0 0.1 7.5e-10 38.3 0.1 1.3 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 EMD59108.1 - 5.4e-05 22.7 0.2 9.8e-05 21.8 0.2 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.21 EMD59108.1 - 0.00053 19.4 0.2 0.0046 16.3 0.2 2.2 1 1 0 1 1 1 1 Beta-eliminating lyase GDC-P PF02347.16 EMD59108.1 - 0.16 10.7 0.0 0.23 10.3 0.0 1.1 1 0 0 1 1 1 0 Glycine cleavage system P-protein COesterase PF00135.28 EMD59109.1 - 1.4e-22 80.3 0.1 1.2e-09 37.6 0.0 3.5 1 1 1 3 3 3 3 Carboxylesterase family DUF438 PF04282.13 EMD59110.1 - 0.012 15.6 0.0 0.022 14.7 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF438) Bac_rhamnosid6H PF17389.2 EMD59112.1 - 1.3e-97 327.2 1.6 2.8e-97 326.0 1.6 1.5 1 1 0 1 1 1 1 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain Bac_rhamnosid_N PF08531.10 EMD59112.1 - 4.6e-32 111.2 0.0 9.7e-32 110.1 0.0 1.5 1 0 0 1 1 1 1 Alpha-L-rhamnosidase N-terminal domain Bac_rhamnosid PF05592.11 EMD59112.1 - 5.1e-16 58.5 0.0 2.8e-15 56.1 0.0 2.1 2 0 0 2 2 2 1 Bacterial alpha-L-rhamnosidase concanavalin-like domain Bac_rhamnosid_C PF17390.2 EMD59112.1 - 2.6e-15 56.0 0.0 8e-15 54.4 0.0 1.8 2 0 0 2 2 2 1 Bacterial alpha-L-rhamnosidase C-terminal domain DUF1793 PF08760.11 EMD59112.1 - 0.02 15.4 0.0 0.052 14.0 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1793) HET PF06985.11 EMD59113.1 - 1.6e-11 44.7 1.5 1.6e-07 31.7 0.1 2.4 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) WD40 PF00400.32 EMD59114.1 - 7.2e-16 58.3 5.0 7.4e-07 29.8 0.4 3.5 3 1 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD59114.1 - 3.3e-06 27.3 0.1 0.089 13.1 0.0 2.6 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EMD59114.1 - 1.4e-05 24.0 1.9 0.028 13.1 0.1 2.1 1 1 1 2 2 2 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 EMD59114.1 - 7.8e-05 21.8 0.8 0.00073 18.6 0.8 2.3 1 1 0 1 1 1 1 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF2071 PF09844.9 EMD59114.1 - 0.0055 16.3 0.0 0.23 11.1 0.0 2.2 2 0 0 2 2 2 1 Uncharacterized conserved protein (COG2071) Nucleoporin_N PF08801.11 EMD59114.1 - 0.016 13.9 0.4 0.11 11.2 0.5 2.0 1 1 1 2 2 2 0 Nup133 N terminal like Gmad1 PF10647.9 EMD59114.1 - 0.048 13.4 0.2 0.39 10.4 0.0 1.9 1 1 1 2 2 2 0 Lipoprotein LpqB beta-propeller domain Nbas_N PF15492.6 EMD59114.1 - 0.054 12.8 2.1 2.3 7.5 0.2 2.1 1 1 1 2 2 2 0 Neuroblastoma-amplified sequence, N terminal DUF1412 PF07203.11 EMD59117.1 - 0.054 13.7 0.0 16 5.8 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1412) DUF347 PF03988.12 EMD59118.1 - 0.016 15.3 0.9 0.029 14.6 0.9 1.4 1 0 0 1 1 1 0 Repeat of Unknown Function (DUF347) TrbC PF04956.13 EMD59118.1 - 0.045 14.0 1.4 0.088 13.0 1.4 1.4 1 0 0 1 1 1 0 TrbC/VIRB2 family Med3 PF11593.8 EMD59118.1 - 1.1 8.4 2.7 1.5 7.9 2.7 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal CT_A_B PF02626.15 EMD59119.1 - 2.8e-52 178.0 0.0 4.4e-52 177.3 0.0 1.3 1 0 0 1 1 1 1 Carboxyltransferase domain, subdomain A and B CT_C_D PF02682.16 EMD59119.1 - 5.4e-14 52.4 0.0 9.6e-14 51.6 0.0 1.3 1 0 0 1 1 1 1 Carboxyltransferase domain, subdomain C and D Biotin_lipoyl PF00364.22 EMD59119.1 - 3.7e-07 29.9 0.6 1.5e-06 28.0 0.2 2.2 2 1 0 2 2 2 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 EMD59119.1 - 4.3e-05 23.3 1.5 8.6e-05 22.3 0.4 2.0 2 0 0 2 2 2 1 Biotin-lipoyl like Biotin_carb_C PF02785.19 EMD59119.1 - 0.00048 20.2 0.0 0.0023 18.0 0.0 2.0 2 0 0 2 2 2 1 Biotin carboxylase C-terminal domain RnfC_N PF13375.6 EMD59119.1 - 0.081 12.9 0.1 0.32 11.0 0.1 1.9 2 0 0 2 2 2 0 RnfC Barrel sandwich hybrid domain HlyD_D23 PF16576.5 EMD59119.1 - 0.18 11.0 0.1 0.36 10.0 0.1 1.4 1 0 0 1 1 1 0 Barrel-sandwich domain of CusB or HlyD membrane-fusion PHD PF00628.29 EMD59120.1 - 1.4e-07 31.2 7.1 2.5e-07 30.5 7.1 1.4 1 0 0 1 1 1 1 PHD-finger ING PF12998.7 EMD59120.1 - 8.2e-05 23.1 0.8 0.00014 22.4 0.0 1.8 2 0 0 2 2 2 1 Inhibitor of growth proteins N-terminal histone-binding zf-HC5HC2H PF13771.6 EMD59120.1 - 0.014 15.7 1.4 0.028 14.7 1.4 1.5 1 0 0 1 1 1 0 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 EMD59120.1 - 0.13 12.4 0.6 0.26 11.5 0.6 1.4 1 0 0 1 1 1 0 PHD-zinc-finger like domain HCO3_cotransp PF00955.21 EMD59122.1 - 7.4e-84 282.4 13.1 5.1e-45 154.3 5.7 2.2 1 1 1 2 2 2 2 HCO3- transporter family Phage_TAC_1 PF06222.11 EMD59123.1 - 0.017 14.9 0.4 0.053 13.3 0.4 1.8 1 0 0 1 1 1 0 Phage tail assembly chaperone SPX PF03105.19 EMD59125.1 - 0.027 14.4 2.4 0.056 13.4 2.4 1.8 1 1 0 1 1 1 0 SPX domain AAA_22 PF13401.6 EMD59125.1 - 0.04 14.2 0.0 0.08 13.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain zf-Di19 PF05605.12 EMD59125.1 - 0.056 13.7 0.6 0.056 13.7 0.6 2.1 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Fe_dep_repr_C PF02742.15 EMD59125.1 - 0.089 12.9 0.1 0.57 10.3 0.1 2.1 2 0 0 2 2 2 0 Iron dependent repressor, metal binding and dimerisation domain zf-C2H2_9 PF16293.5 EMD59125.1 - 0.18 11.7 0.8 0.77 9.6 0.0 2.2 2 0 0 2 2 2 0 C2H2 type zinc-finger (1 copy) zf-C2H2_4 PF13894.6 EMD59125.1 - 6.3 7.9 6.4 1.4 9.9 0.1 3.0 3 0 0 3 3 3 0 C2H2-type zinc finger Phosphodiest PF01663.22 EMD59127.1 - 3.3e-13 50.0 0.4 6.9e-13 48.9 0.4 1.5 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.18 EMD59127.1 - 0.00017 21.1 0.4 0.00053 19.4 0.6 1.6 2 0 0 2 2 2 1 Metalloenzyme superfamily Sulfatase PF00884.23 EMD59127.1 - 0.00067 19.1 0.2 0.0042 16.5 0.1 2.3 2 0 0 2 2 2 1 Sulfatase PglZ PF08665.12 EMD59127.1 - 0.032 14.3 0.2 5.2 7.1 0.0 2.3 2 0 0 2 2 2 0 PglZ domain EptA_B_N PF08019.12 EMD59127.1 - 0.83 9.5 7.8 0.57 10.1 4.0 2.8 2 0 0 2 2 2 0 Phosphoethanolamine transferase EptA/EptB PilX_N PF14341.6 EMD59128.1 - 0.012 15.6 1.0 0.021 14.8 1.0 1.3 1 0 0 1 1 1 0 PilX N-terminal PUF PF00806.19 EMD59130.1 - 3.4e-61 199.6 5.9 1.8e-08 33.6 0.2 8.4 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat sCache_2 PF17200.4 EMD59130.1 - 0.037 13.9 0.7 8.7 6.2 0.0 4.0 4 1 1 5 5 5 0 Single Cache domain 2 DUF4372 PF14294.6 EMD59130.1 - 0.065 13.4 0.0 0.35 11.0 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4372) TBPIP PF07106.13 EMD59130.1 - 0.71 9.9 3.4 5.7 7.0 0.0 3.6 3 1 1 4 4 4 0 TBPIP/Hop2 winged helix domain Thioredox_DsbH PF03190.15 EMD59132.1 - 8.9e-74 246.9 0.0 1.5e-73 246.2 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF255 Thioredoxin_7 PF13899.6 EMD59132.1 - 1.6e-08 34.6 0.0 3.3e-08 33.6 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin-like Glyco_hydro_9 PF00759.19 EMD59132.1 - 7.2e-05 22.4 0.1 0.00014 21.4 0.1 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 9 Glyco_hydro_88 PF07470.13 EMD59132.1 - 0.027 13.5 0.5 7.7 5.5 0.1 2.7 2 1 0 2 2 2 0 Glycosyl Hydrolase Family 88 Glyco_hydro_76 PF03663.14 EMD59132.1 - 0.063 12.8 1.2 0.18 11.3 1.0 1.8 1 1 1 2 2 2 0 Glycosyl hydrolase family 76 HTH_10 PF04967.12 EMD59132.1 - 0.1 12.4 0.8 0.52 10.2 0.1 2.6 4 0 0 4 4 4 0 HTH DNA binding domain Thioredoxin_2 PF13098.6 EMD59132.1 - 0.2 12.1 0.0 0.47 10.9 0.0 1.6 1 0 0 1 1 1 0 Thioredoxin-like domain MFS_1 PF07690.16 EMD59133.1 - 5e-43 147.4 28.5 5e-43 147.4 28.5 1.8 1 1 0 1 1 1 1 Major Facilitator Superfamily OATP PF03137.20 EMD59133.1 - 0.0023 16.3 0.5 0.0023 16.3 0.5 2.3 2 1 1 3 3 3 1 Organic Anion Transporter Polypeptide (OATP) family Shal-type PF11601.8 EMD59133.1 - 0.15 11.6 1.3 6.1 6.5 0.5 2.5 2 0 0 2 2 2 0 Shal-type voltage-gated potassium channels, N-terminal Cofac_haem_bdg PF04187.13 EMD59134.1 - 0.074 13.0 0.1 0.13 12.3 0.1 1.3 1 0 0 1 1 1 0 Haem-binding uptake, Tiki superfamily, ChaN F-box-like PF12937.7 EMD59135.1 - 3e-06 27.0 0.1 1.1e-05 25.2 0.1 2.0 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EMD59135.1 - 0.015 15.2 0.1 0.04 13.8 0.1 1.8 1 0 0 1 1 1 0 F-box domain Sld7_C PF18596.1 EMD59136.1 - 1.6e-28 98.7 0.2 2.7e-28 97.9 0.2 1.4 1 0 0 1 1 1 1 Sld7 C-terminal domain Sld7_N PF18636.1 EMD59136.1 - 0.00053 20.3 0.2 0.0011 19.3 0.2 1.5 1 0 0 1 1 1 1 Mitochondrial morphogenesis protein SLD7 N-terminal domain Transket_pyr PF02779.24 EMD59137.1 - 0.11 12.2 0.1 0.16 11.6 0.1 1.2 1 0 0 1 1 1 0 Transketolase, pyrimidine binding domain zf-ANAPC11 PF12861.7 EMD59137.1 - 0.17 12.0 0.8 0.29 11.2 0.7 1.5 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger CorA PF01544.18 EMD59139.1 - 9.4e-08 31.7 0.2 1.5e-07 31.0 0.2 1.3 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein DUF2207 PF09972.9 EMD59139.1 - 0.14 10.9 0.0 0.18 10.5 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) adh_short PF00106.25 EMD59140.1 - 1.1e-23 83.7 0.1 1.8e-23 83.0 0.1 1.4 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD59140.1 - 9.4e-18 64.6 0.1 1.7e-17 63.8 0.1 1.4 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Elong_Iki1 PF10483.9 EMD59141.1 - 3.1e-81 273.1 0.0 3.6e-81 273.0 0.0 1.0 1 0 0 1 1 1 1 Elongator subunit Iki1 SNRNP27 PF08648.12 EMD59143.1 - 1.7e-25 88.8 0.9 2.9e-25 88.1 0.9 1.4 1 0 0 1 1 1 1 U4/U6.U5 small nuclear ribonucleoproteins Glyco_hydro_63 PF03200.16 EMD59144.1 - 3e-173 577.1 8.9 4.3e-173 576.6 3.5 2.8 2 1 0 2 2 2 1 Glycosyl hydrolase family 63 C-terminal domain Glyco_hydro_63N PF16923.5 EMD59144.1 - 2.5e-87 292.7 0.0 1.4e-86 290.3 0.0 2.1 2 0 0 2 2 2 1 Glycosyl hydrolase family 63 N-terminal domain Trehalase PF01204.18 EMD59144.1 - 6.3e-08 31.9 0.6 6.3e-08 31.9 0.6 1.6 2 0 0 2 2 2 1 Trehalase GDE_C PF06202.14 EMD59144.1 - 0.0063 15.5 0.1 0.012 14.6 0.1 1.4 1 0 0 1 1 1 1 Amylo-alpha-1,6-glucosidase Surface_Ag_2 PF01617.17 EMD59144.1 - 0.075 12.4 0.0 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 Surface antigen E1-E2_ATPase PF00122.20 EMD59147.1 - 1.1e-34 119.5 17.9 1.6e-34 119.0 4.3 4.3 4 1 0 4 4 4 2 E1-E2 ATPase Hydrolase PF00702.26 EMD59147.1 - 4.5e-16 59.8 0.1 1.2e-15 58.3 0.1 1.8 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EMD59147.1 - 2.4e-12 46.4 0.0 5.4e-12 45.2 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EMD59147.1 - 0.005 16.6 0.5 0.026 14.3 0.1 2.1 1 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase MFS_1 PF07690.16 EMD59148.1 - 2.7e-29 102.2 34.0 2.7e-29 102.2 34.0 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EMD59148.1 - 1.4e-15 57.1 10.0 8.4e-15 54.6 0.3 2.3 2 1 0 2 2 2 2 Sugar (and other) transporter Folate_carrier PF01770.18 EMD59148.1 - 0.0092 14.8 0.2 0.0092 14.8 0.2 2.4 2 1 0 2 2 2 1 Reduced folate carrier PgpA PF04608.13 EMD59148.1 - 4.6 7.3 8.2 0.43 10.6 0.2 2.9 3 0 0 3 3 3 0 Phosphatidylglycerophosphatase A Actin PF00022.19 EMD59149.1 - 2.9e-150 500.4 0.0 1.1e-149 498.5 0.0 1.7 1 1 0 1 1 1 1 Actin Fes1 PF08609.10 EMD59150.1 - 1.6e-25 89.7 2.0 1.6e-25 89.7 2.0 1.9 2 0 0 2 2 2 1 Nucleotide exchange factor Fes1 HEAT PF02985.22 EMD59150.1 - 7.6e-07 28.9 0.0 0.072 13.4 0.0 3.5 3 0 0 3 3 3 2 HEAT repeat HEAT_EZ PF13513.6 EMD59150.1 - 3.9e-06 27.2 0.0 1.4e-05 25.5 0.0 2.0 1 0 0 1 1 1 1 HEAT-like repeat HEAT_2 PF13646.6 EMD59150.1 - 3.6e-05 24.1 0.2 0.00012 22.4 0.1 1.9 2 0 0 2 2 2 1 HEAT repeats Arm PF00514.23 EMD59150.1 - 0.00077 19.4 0.0 1.8 8.7 0.0 2.7 2 0 0 2 2 2 2 Armadillo/beta-catenin-like repeat SpoIIIAH PF12685.7 EMD59150.1 - 0.23 11.3 2.8 0.41 10.4 2.8 1.3 1 0 0 1 1 1 0 SpoIIIAH-like protein PAC3 PF10178.9 EMD59151.1 - 4.4e-05 23.5 0.0 7.6e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 Proteasome assembly chaperone 3 HA2 PF04408.23 EMD59152.1 - 4.9e-21 75.0 0.1 4.9e-21 75.0 0.1 2.9 3 0 0 3 3 3 1 Helicase associated domain (HA2) Helicase_C PF00271.31 EMD59152.1 - 8.6e-14 51.8 0.1 4.4e-12 46.3 0.0 3.1 3 0 0 3 3 3 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.16 EMD59152.1 - 4e-09 36.7 0.0 1e-08 35.4 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.29 EMD59152.1 - 1e-08 35.2 0.1 3.1e-08 33.6 0.1 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EMD59152.1 - 4.9e-05 23.6 0.1 0.00035 20.8 0.0 2.4 2 0 0 2 2 2 1 AAA domain ResIII PF04851.15 EMD59152.1 - 0.0023 17.9 0.0 1.4 8.9 0.0 2.9 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit AAA_19 PF13245.6 EMD59152.1 - 0.0062 16.9 0.1 0.015 15.7 0.1 1.6 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.6 EMD59152.1 - 0.012 15.3 0.1 0.027 14.2 0.1 1.5 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 EMD59152.1 - 0.098 12.1 0.0 0.23 10.9 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein Sugar_tr PF00083.24 EMD59153.1 - 7.5e-79 265.7 23.8 8.6e-79 265.5 23.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD59153.1 - 5.7e-17 61.7 26.9 5.7e-17 61.7 26.9 2.1 1 1 2 3 3 3 2 Major Facilitator Superfamily PrmC_N PF17827.1 EMD59154.1 - 0.00013 22.5 0.7 0.00037 21.0 0.7 1.8 1 0 0 1 1 1 1 PrmC N-terminal domain Methyltransf_31 PF13847.6 EMD59154.1 - 0.006 16.4 0.0 0.023 14.5 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_10 PF05971.12 EMD59154.1 - 0.0099 15.2 0.0 0.033 13.5 0.0 1.8 2 0 0 2 2 2 1 RNA methyltransferase Methyltransf_25 PF13649.6 EMD59154.1 - 0.026 15.2 0.0 0.072 13.8 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain PAP2 PF01569.21 EMD59155.1 - 2.4e-14 53.3 5.1 2.4e-14 53.3 5.1 2.1 2 1 0 2 2 2 1 PAP2 superfamily DUF212 PF02681.14 EMD59155.1 - 0.00021 21.4 0.1 0.036 14.2 0.0 2.3 2 0 0 2 2 2 2 Divergent PAP2 family Virul_fac_BrkB PF03631.15 EMD59155.1 - 0.0014 18.3 6.6 0.0014 18.3 6.6 1.4 1 1 0 1 1 1 1 Virulence factor BrkB TauE PF01925.19 EMD59155.1 - 0.25 10.9 10.0 0.52 9.9 10.0 1.6 1 1 0 1 1 1 0 Sulfite exporter TauE/SafE UbiA PF01040.18 EMD59155.1 - 0.28 10.5 18.8 0.34 10.1 11.3 2.1 1 1 1 2 2 2 0 UbiA prenyltransferase family PrgI PF12666.7 EMD59155.1 - 4.7 8.0 8.2 1.2 9.9 1.4 2.7 2 1 1 3 3 3 0 PrgI family protein IBR PF01485.21 EMD59156.1 - 1.7e-21 76.2 37.5 1.7e-15 57.0 0.8 4.0 3 1 1 4 4 4 2 IBR domain, a half RING-finger domain RWD PF05773.22 EMD59156.1 - 1.6e-17 63.8 0.2 6.8e-17 61.8 0.2 2.0 2 0 0 2 2 2 1 RWD domain zf-RING_11 PF17123.5 EMD59156.1 - 0.00095 18.9 5.7 0.00095 18.9 5.7 2.9 3 0 0 3 3 3 1 RING-like zinc finger zf-RING_5 PF14634.6 EMD59156.1 - 0.0081 16.1 12.4 0.0081 16.1 12.4 3.9 2 2 1 3 3 3 1 zinc-RING finger domain zf-RING_2 PF13639.6 EMD59156.1 - 0.029 14.7 10.2 0.029 14.7 10.2 4.4 3 2 1 4 4 4 0 Ring finger domain UL42 PF17638.2 EMD59157.1 - 0.015 15.2 4.2 0.015 15.2 4.2 2.4 2 1 0 2 2 2 0 HCMV UL42 FTA4 PF13093.6 EMD59157.1 - 0.056 13.3 1.2 0.091 12.6 1.2 1.2 1 0 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 Pyr_excise PF03013.14 EMD59157.1 - 0.082 12.9 0.1 0.13 12.2 0.1 1.3 1 0 0 1 1 1 0 Pyrimidine dimer DNA glycosylase DUF2613 PF11021.8 EMD59158.1 - 0.18 11.9 0.1 0.27 11.4 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2613) Glyco_hydro_43 PF04616.14 EMD59159.1 - 5.4e-23 81.7 9.0 5e-22 78.5 9.0 2.1 1 1 0 1 1 1 1 Glycosyl hydrolases family 43 Gal_Lectin PF02140.18 EMD59160.1 - 0.032 14.7 2.1 0.032 14.7 2.1 2.0 1 1 1 2 2 2 0 Galactose binding lectin domain Ldh_1_C PF02866.18 EMD59161.1 - 0.19 11.6 0.0 0.9 9.4 0.0 1.9 1 1 1 2 2 2 0 lactate/malate dehydrogenase, alpha/beta C-terminal domain DUF3659 PF12396.8 EMD59162.1 - 0.83 9.6 6.8 1.6 8.7 4.8 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF3659) 4HBT_2 PF13279.6 EMD59164.1 - 6.4e-06 26.7 0.0 9.5e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 Thioesterase-like superfamily SUI1 PF01253.22 EMD59165.1 - 3.8e-22 78.6 0.1 9.2e-22 77.4 0.0 1.7 2 0 0 2 2 2 1 Translation initiation factor SUI1 Pre-PUA PF17832.1 EMD59165.1 - 6.7e-08 33.1 0.0 2.2e-07 31.5 0.0 1.9 2 1 0 2 2 2 1 Pre-PUA-like domain SWIB PF02201.18 EMD59165.1 - 0.0095 15.8 0.0 0.022 14.7 0.0 1.6 1 0 0 1 1 1 1 SWIB/MDM2 domain Kin17_mid PF10357.9 EMD59165.1 - 0.056 13.4 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 Domain of Kin17 curved DNA-binding protein PQQ_3 PF13570.6 EMD59165.1 - 5.7 7.6 5.5 41 4.8 0.1 2.6 2 0 0 2 2 2 0 PQQ-like domain Chromo PF00385.24 EMD59168.1 - 0.017 15.0 0.5 0.04 13.8 0.5 1.6 1 0 0 1 1 1 0 Chromo (CHRromatin Organisation MOdifier) domain Ndufs5 PF10200.9 EMD59168.1 - 0.32 11.3 1.3 0.54 10.6 0.1 2.0 2 0 0 2 2 2 0 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa DUF572 PF04502.13 EMD59168.1 - 2.1 7.9 18.0 4.3 6.9 18.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF572) zf-CCCH_2 PF14608.6 EMD59168.1 - 8.4 7.0 18.0 1.6 9.3 1.1 3.4 3 0 0 3 3 3 0 RNA-binding, Nab2-type zinc finger Ras PF00071.22 EMD59169.1 - 1.8e-63 213.0 0.2 2.1e-63 212.7 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMD59169.1 - 2.1e-35 121.5 0.2 2.9e-35 121.1 0.2 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMD59169.1 - 3e-13 49.6 0.1 3.9e-13 49.2 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EMD59169.1 - 8.1e-08 32.3 0.1 1.3e-07 31.7 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EMD59169.1 - 9.1e-05 22.4 0.1 0.016 15.1 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 EMD59169.1 - 0.00025 20.7 0.1 0.001 18.6 0.1 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EMD59169.1 - 0.00039 19.8 0.1 0.00062 19.2 0.1 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_22 PF13401.6 EMD59169.1 - 0.0027 18.0 0.0 0.017 15.4 0.0 2.0 1 1 0 1 1 1 1 AAA domain SRPRB PF09439.10 EMD59169.1 - 0.011 15.1 0.0 0.017 14.5 0.0 1.3 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_14 PF13173.6 EMD59169.1 - 0.012 15.6 0.1 0.037 14.0 0.1 1.8 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EMD59169.1 - 0.02 15.3 0.1 0.033 14.6 0.1 1.5 1 1 0 1 1 1 0 AAA ATPase domain AAA_24 PF13479.6 EMD59169.1 - 0.026 14.3 0.1 0.061 13.0 0.1 1.7 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EMD59169.1 - 0.026 15.0 0.1 0.037 14.5 0.1 1.5 1 1 0 1 1 1 0 ABC transporter TniB PF05621.11 EMD59169.1 - 0.038 13.4 0.0 0.17 11.3 0.0 1.9 2 0 0 2 2 2 0 Bacterial TniB protein SpoIIID PF12116.8 EMD59169.1 - 0.068 13.3 0.1 1.6 8.8 0.0 2.4 2 0 0 2 2 2 0 Stage III sporulation protein D FeoB_N PF02421.18 EMD59169.1 - 0.098 12.2 0.1 0.25 10.8 0.0 1.6 2 0 0 2 2 2 0 Ferrous iron transport protein B AAA_21 PF13304.6 EMD59169.1 - 0.11 12.3 0.6 0.18 11.6 0.6 1.5 1 1 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_7 PF12775.7 EMD59169.1 - 0.12 11.9 0.0 0.21 11.1 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region TPT PF03151.16 EMD59170.1 - 1e-56 192.5 8.4 1.2e-56 192.2 8.4 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family UAA PF08449.11 EMD59170.1 - 1.4e-09 37.7 12.2 3.5e-09 36.3 12.2 1.7 1 1 0 1 1 1 1 UAA transporter family EamA PF00892.20 EMD59170.1 - 8.1e-09 35.8 27.3 9.4e-06 25.8 11.4 3.0 2 1 0 2 2 2 2 EamA-like transporter family Nuc_sug_transp PF04142.15 EMD59170.1 - 0.04 13.1 0.1 0.04 13.1 0.1 1.7 2 0 0 2 2 2 0 Nucleotide-sugar transporter Wzy_C PF04932.15 EMD59170.1 - 0.045 13.4 1.2 0.22 11.1 0.0 2.3 2 0 0 2 2 2 0 O-Antigen ligase Phage_holin_5_2 PF16079.5 EMD59170.1 - 3.2 8.1 6.4 3.9 7.9 1.1 3.1 3 0 0 3 3 3 0 Phage holin family Hol44, in holin superfamily V Peptidase_S9 PF00326.21 EMD59171.1 - 1.6e-05 24.5 0.1 3e-05 23.6 0.1 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family PUF PF00806.19 EMD59172.1 - 9.1e-34 113.3 4.9 9.8e-05 21.8 0.0 9.1 8 1 0 9 9 9 7 Pumilio-family RNA binding repeat RraB PF06877.11 EMD59172.1 - 0.0092 16.7 0.0 0.076 13.7 0.0 2.2 2 0 0 2 2 2 1 Regulator of ribonuclease activity B HIG_1_N PF04588.13 EMD59173.1 - 3.4e-06 27.2 0.2 3.4e-06 27.2 0.2 2.6 3 0 0 3 3 3 1 Hypoxia induced protein conserved region RHD3 PF05879.12 EMD59175.1 - 0 1042.0 0.0 0 1041.8 0.0 1.0 1 0 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) GBP PF02263.19 EMD59175.1 - 5.6e-08 32.4 0.1 9.9e-08 31.6 0.1 1.3 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain Dynamin_N PF00350.23 EMD59175.1 - 1e-05 25.7 0.0 2.8e-05 24.3 0.0 1.8 1 0 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 EMD59175.1 - 0.00029 20.9 0.0 0.00069 19.7 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_28 PF13521.6 EMD59175.1 - 0.0095 16.2 0.1 0.03 14.5 0.1 1.9 1 0 0 1 1 1 1 AAA domain Septin PF00735.18 EMD59175.1 - 0.039 13.2 0.1 0.083 12.2 0.1 1.5 1 0 0 1 1 1 0 Septin DAO PF01266.24 EMD59176.1 - 1.8e-45 156.1 0.1 2.1e-45 155.8 0.1 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EMD59176.1 - 0.048 12.9 0.0 0.27 10.4 0.0 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase PBP3 PF18056.1 EMD59176.1 - 0.14 12.3 0.0 0.22 11.6 0.0 1.3 1 0 0 1 1 1 0 Penicillin Binding Protein 3 Domain WW PF00397.26 EMD59177.1 - 3.3e-10 39.9 7.6 3.3e-10 39.9 7.6 1.7 2 0 0 2 2 2 1 WW domain E1-E2_ATPase PF00122.20 EMD59179.1 - 7.5e-50 169.0 5.8 7.5e-50 169.0 5.8 2.8 4 0 0 4 4 4 1 E1-E2 ATPase Hydrolase PF00702.26 EMD59179.1 - 1.1e-16 61.8 0.0 3.1e-16 60.3 0.0 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EMD59179.1 - 6.3e-11 41.8 0.0 1.7e-10 40.4 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EMD59179.1 - 0.013 15.2 0.1 0.013 15.2 0.1 1.8 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EMD59179.1 - 0.019 15.0 0.0 0.037 14.1 0.0 1.4 1 0 0 1 1 1 0 Cation transport ATPase (P-type) Aldo_ket_red PF00248.21 EMD59180.1 - 2.6e-49 168.0 0.1 3.9e-48 164.1 0.1 1.9 1 1 0 1 1 1 1 Aldo/keto reductase family Arylsulfotran_2 PF14269.6 EMD59180.1 - 0.11 11.9 0.0 0.15 11.4 0.0 1.2 1 0 0 1 1 1 0 Arylsulfotransferase (ASST) DUF382 PF04037.13 EMD59181.1 - 2e-57 192.8 0.3 2e-57 192.8 0.3 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF382) PSP PF04046.16 EMD59181.1 - 7.8e-23 80.1 5.5 1.8e-22 78.9 5.5 1.7 1 0 0 1 1 1 1 PSP RNA_pol_Rpb2_6 PF00562.28 EMD59183.1 - 1.6e-118 396.2 0.0 2.8e-118 395.4 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 EMD59183.1 - 3.8e-52 176.8 0.3 5.8e-52 176.2 0.3 1.3 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_7 PF04560.20 EMD59183.1 - 6.3e-33 113.0 0.9 6.3e-33 113.0 0.9 2.0 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_2 PF04561.14 EMD59183.1 - 8.8e-31 107.0 0.5 1.9e-30 105.9 0.5 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_4 PF04566.13 EMD59183.1 - 3.3e-23 81.7 0.1 8.8e-23 80.4 0.1 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_3 PF04565.16 EMD59183.1 - 3e-18 65.7 0.0 7.7e-18 64.4 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.17 EMD59183.1 - 6.9e-10 39.3 3.1 2.9e-09 37.4 0.7 2.8 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 5 Mpt_N PF09176.11 EMD59183.1 - 0.028 14.5 0.0 0.38 10.9 0.0 2.5 2 0 0 2 2 2 0 Methylene-tetrahydromethanopterin dehydrogenase, N-terminal F-box PF00646.33 EMD59184.1 - 0.0005 19.9 1.3 0.17 11.8 0.0 2.6 3 1 0 3 3 3 2 F-box domain F-box-like PF12937.7 EMD59184.1 - 0.0014 18.5 0.2 0.59 10.1 0.1 2.4 2 0 0 2 2 2 2 F-box-like F-box-like_2 PF13013.6 EMD59184.1 - 0.017 15.1 0.0 0.031 14.2 0.0 1.7 1 1 0 1 1 1 0 F-box-like domain Pga1 PF10333.9 EMD59185.1 - 1.5e-05 24.9 0.7 3.1e-05 23.9 0.7 1.7 1 1 0 1 1 1 1 GPI-Mannosyltransferase II co-activator Tubulin PF00091.25 EMD59186.1 - 6.4e-67 225.6 0.0 1.3e-66 224.6 0.0 1.5 2 0 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EMD59186.1 - 4.1e-51 172.4 0.1 7.2e-51 171.6 0.1 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 EMD59186.1 - 0.0018 18.0 0.0 0.0042 16.8 0.0 1.6 1 0 0 1 1 1 1 Tubulin domain Misat_Tub_SegII PF10644.9 EMD59186.1 - 0.13 12.5 0.0 0.24 11.7 0.0 1.4 1 0 0 1 1 1 0 Misato Segment II tubulin-like domain Mcl1_mid PF12341.8 EMD59187.1 - 2.6e-95 319.2 0.1 2.1e-93 312.9 0.0 2.8 3 0 0 3 3 3 1 Minichromosome loss protein, Mcl1, middle region WD40 PF00400.32 EMD59187.1 - 2.1e-16 60.0 3.7 6.1e-05 23.7 0.2 7.7 8 0 0 8 8 8 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD59187.1 - 2.8e-15 56.4 1.3 1.8e-05 25.0 0.1 6.8 3 1 3 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain Coatomer_WDAD PF04053.14 EMD59187.1 - 2.8e-05 23.3 0.1 9.4e-05 21.6 0.2 1.7 1 1 1 2 2 2 1 Coatomer WD associated region Ge1_WD40 PF16529.5 EMD59187.1 - 0.00024 20.2 0.4 0.36 9.7 0.1 3.2 2 1 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 EMD59187.1 - 0.0077 16.1 0.6 1.3 8.9 0.0 3.4 2 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A Frtz PF11768.8 EMD59187.1 - 0.026 12.9 0.0 0.091 11.1 0.0 1.7 1 1 1 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz PQQ_3 PF13570.6 EMD59187.1 - 0.042 14.3 1.9 5.4 7.6 0.1 3.5 3 0 0 3 3 3 0 PQQ-like domain MAGE PF01454.19 EMD59187.1 - 0.084 12.6 0.1 0.14 11.9 0.1 1.3 1 0 0 1 1 1 0 MAGE family PD40 PF07676.12 EMD59187.1 - 0.086 12.8 0.1 6.1 6.9 0.0 3.7 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat TRAP_alpha PF03896.16 EMD59187.1 - 0.2 10.8 2.3 0.39 9.9 2.3 1.4 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit MFS_1 PF07690.16 EMD59188.1 - 1.8e-33 116.0 31.0 1.8e-33 116.0 31.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EMD59188.1 - 1.4e-09 37.4 6.6 1.4e-09 37.4 6.6 3.3 2 1 1 3 3 3 1 Sugar (and other) transporter TRI12 PF06609.13 EMD59188.1 - 7.9e-07 27.9 1.4 1.3e-06 27.1 1.4 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF2012 PF09430.10 EMD59189.1 - 8.1e-26 90.6 0.0 1.1e-25 90.1 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2012) SOP4 PF17081.5 EMD59189.1 - 0.00045 19.8 0.0 0.21 11.1 0.0 2.2 2 0 0 2 2 2 2 Suppressor of PMA 1-7 protein LtrA PF06772.11 EMD59190.1 - 5.7e-42 144.2 21.1 7.4e-42 143.8 21.1 1.1 1 0 0 1 1 1 1 Bacterial low temperature requirement A protein (LtrA) Histone PF00125.24 EMD59190.1 - 0.05 14.0 0.0 0.11 12.9 0.0 1.5 1 0 0 1 1 1 0 Core histone H2A/H2B/H3/H4 LRRFIP PF09738.9 EMD59190.1 - 0.097 12.1 2.1 0.14 11.6 2.1 1.2 1 0 0 1 1 1 0 LRRFIP family ATG16 PF08614.11 EMD59190.1 - 0.22 11.7 2.0 0.34 11.1 2.0 1.2 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) Na_H_Exchanger PF00999.21 EMD59191.1 - 9.4e-48 162.9 23.2 1.2e-47 162.5 23.2 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Nucleoporin_FG2 PF15967.5 EMD59191.1 - 0.11 11.0 0.0 0.16 10.5 0.0 1.1 1 0 0 1 1 1 0 Nucleoporin FG repeated region Molybdopterin PF00384.22 EMD59192.1 - 3.5e-74 250.3 0.0 8e-72 242.5 0.0 2.2 1 1 0 1 1 1 1 Molybdopterin oxidoreductase Fer2_4 PF13510.6 EMD59192.1 - 3.3e-20 71.9 0.2 8.2e-20 70.6 0.2 1.7 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain NADH_dhqG_C PF09326.11 EMD59192.1 - 8.1e-18 64.9 0.0 2.1e-17 63.5 0.0 1.8 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase subunit G, C-terminal NADH-G_4Fe-4S_3 PF10588.9 EMD59192.1 - 2.8e-17 62.0 0.2 2.8e-17 62.0 0.2 2.2 2 0 0 2 2 2 1 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region Fer2 PF00111.27 EMD59192.1 - 5.8e-08 32.6 0.7 5.8e-08 32.6 0.7 2.1 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain TPP_enzyme_M PF00205.22 EMD59192.1 - 0.0024 17.6 0.0 0.16 11.7 0.0 2.4 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain Fer4 PF00037.27 EMD59192.1 - 0.12 12.2 1.1 3.5 7.6 0.3 2.5 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_19 PF06902.11 EMD59192.1 - 0.17 12.0 0.4 36 4.5 0.0 2.8 2 0 0 2 2 2 0 Divergent 4Fe-4S mono-cluster Fer4_17 PF13534.6 EMD59192.1 - 4.1 8.0 5.6 0.63 10.6 1.2 2.0 2 0 0 2 2 2 0 4Fe-4S dicluster domain Fer4_7 PF12838.7 EMD59192.1 - 9.5 6.9 6.7 2.6 8.7 1.6 2.6 3 0 0 3 3 3 0 4Fe-4S dicluster domain FA_desaturase PF00487.24 EMD59193.1 - 2e-24 86.8 20.7 4.9e-24 85.5 20.7 1.5 1 1 0 1 1 1 1 Fatty acid desaturase DUF3474 PF11960.8 EMD59193.1 - 1.5e-05 25.2 0.0 3.6e-05 24.0 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3474) Mid1 PF12929.7 EMD59194.1 - 5.2e-150 500.3 6.0 6.2e-150 500.1 6.0 1.0 1 0 0 1 1 1 1 Stretch-activated Ca2+-permeable channel component Fz PF01392.22 EMD59194.1 - 0.0044 17.6 7.7 0.017 15.8 1.3 2.6 2 0 0 2 2 2 2 Fz domain Glyco_hydro_6 PF01341.17 EMD59195.1 - 1.4e-108 363.3 0.2 1.6e-108 363.0 0.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 6 RNA_pol_Rpc82 PF05645.13 EMD59197.1 - 1.4e-49 169.2 0.0 3.3e-46 158.1 0.0 2.8 3 0 0 3 3 3 2 RNA polymerase III subunit RPC82 HTH_9 PF08221.11 EMD59197.1 - 9.9e-22 76.8 2.1 2e-15 56.6 0.2 4.8 5 0 0 5 5 5 2 RNA polymerase III subunit RPC82 helix-turn-helix domain TFIIE_alpha PF02002.17 EMD59197.1 - 0.0039 17.0 2.0 0.93 9.4 1.1 3.0 2 1 1 3 3 3 2 TFIIE alpha subunit TrmB PF01978.19 EMD59197.1 - 0.018 14.9 0.2 29 4.6 0.0 4.1 4 0 0 4 4 4 0 Sugar-specific transcriptional regulator TrmB B-block_TFIIIC PF04182.12 EMD59197.1 - 0.056 13.6 0.0 1.4 9.1 0.0 3.1 3 0 0 3 3 3 0 B-block binding subunit of TFIIIC Peptidase_M16_C PF05193.21 EMD59198.1 - 2.9e-12 47.0 0.0 8.5e-12 45.5 0.0 1.8 2 0 0 2 2 2 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EMD59198.1 - 6.8e-12 45.6 0.0 1.5e-11 44.5 0.0 1.5 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) CBFD_NFYB_HMF PF00808.23 EMD59199.1 - 4.9e-05 23.5 0.0 7.3e-05 23.0 0.0 1.3 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-W PF15510.6 EMD59199.1 - 6.9e-05 23.0 0.0 8.2e-05 22.8 0.0 1.1 1 0 0 1 1 1 1 CENP-W protein TAFII28 PF04719.14 EMD59199.1 - 0.024 14.7 0.1 0.034 14.2 0.1 1.3 1 1 0 1 1 1 0 hTAFII28-like protein conserved region Mak10 PF04112.13 EMD59200.1 - 1.1e-60 203.9 0.0 2.3e-60 202.9 0.0 1.5 1 0 0 1 1 1 1 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase ATP-synt_Eps PF04627.13 EMD59201.1 - 1.3e-23 82.7 1.2 2.3e-23 81.9 1.2 1.4 1 0 0 1 1 1 1 Mitochondrial ATP synthase epsilon chain Proteasome PF00227.26 EMD59202.1 - 2.3e-48 164.2 0.0 3e-48 163.9 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EMD59202.1 - 4.7e-12 45.3 0.3 4.7e-12 45.3 0.3 1.6 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature DUF1403 PF07183.11 EMD59202.1 - 0.0028 17.3 0.0 0.0039 16.8 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1403) Flg_hook PF02120.16 EMD59202.1 - 0.013 15.4 0.8 1.3 9.0 0.0 2.9 2 1 1 3 3 3 0 Flagellar hook-length control protein FliK Vps55 PF04133.14 EMD59203.1 - 4.6e-42 142.7 7.6 5.2e-42 142.5 7.6 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting 55 DUF4349 PF14257.6 EMD59203.1 - 0.12 11.8 0.2 0.12 11.8 0.2 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4349) Nramp PF01566.18 EMD59203.1 - 0.46 9.4 10.3 0.73 8.7 3.0 2.1 2 0 0 2 2 2 0 Natural resistance-associated macrophage protein UPF0220 PF05255.11 EMD59204.1 - 2.3e-72 242.0 3.5 2.6e-72 241.8 3.5 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0220) Abhydrolase_1 PF00561.20 EMD59206.1 - 2e-10 40.8 0.0 7.2e-09 35.7 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EMD59206.1 - 0.00017 20.9 0.0 0.00057 19.2 0.0 1.7 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EMD59206.1 - 0.00086 20.0 0.1 0.0014 19.3 0.1 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Cohesin_load PF10345.9 EMD59207.1 - 1.1e-112 377.5 0.0 1.5e-112 377.0 0.0 1.2 1 0 0 1 1 1 1 Cohesin loading factor HemY_N PF07219.13 EMD59208.1 - 0.1 12.8 3.1 0.14 12.4 3.1 1.3 1 0 0 1 1 1 0 HemY protein N-terminus zf-CCHC PF00098.23 EMD59208.1 - 0.18 12.0 3.0 0.33 11.1 3.0 1.4 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_2 PF13696.6 EMD59208.1 - 0.37 10.6 1.1 0.51 10.2 1.1 1.2 1 0 0 1 1 1 0 Zinc knuckle Trypan_PARP PF05887.11 EMD59209.1 - 1.3e-12 47.8 185.0 0.00054 19.9 10.5 4.2 2 1 2 4 4 4 4 Procyclic acidic repetitive protein (PARP) TonB_N PF16031.5 EMD59209.1 - 5.3e-05 23.7 16.2 5.3e-05 23.7 16.2 5.4 2 1 0 2 2 2 1 TonB polyproline region MANEC PF07502.14 EMD59209.1 - 0.00048 20.4 2.3 0.43 10.9 0.2 2.4 2 0 0 2 2 2 2 MANEC domain PAN_4 PF14295.6 EMD59209.1 - 0.00077 19.3 5.2 0.04 13.8 0.3 3.0 2 0 0 2 2 2 2 PAN domain PAN_2 PF08276.11 EMD59209.1 - 0.0009 19.3 4.1 0.081 13.0 0.1 2.5 2 0 0 2 2 2 2 PAN-like domain Chitin_bind_1 PF00187.19 EMD59209.1 - 0.0058 17.1 14.5 0.0058 17.1 14.5 2.4 3 0 0 3 3 3 1 Chitin recognition protein PAN_3 PF08277.12 EMD59209.1 - 0.0061 16.3 5.9 0.28 11.0 0.2 2.5 2 0 0 2 2 2 2 PAN-like domain LCM PF04072.14 EMD59209.1 - 0.025 14.5 0.0 0.036 14.0 0.0 1.1 1 0 0 1 1 1 0 Leucine carboxyl methyltransferase JmjC PF02373.22 EMD59211.1 - 2.1e-37 128.0 0.6 4.8e-37 126.9 0.6 1.7 1 0 0 1 1 1 1 JmjC domain, hydroxylase zf-HC5HC2H_2 PF13832.6 EMD59211.1 - 1.3e-18 67.1 2.5 2.3e-18 66.3 2.5 1.4 1 0 0 1 1 1 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 EMD59211.1 - 4.3e-18 65.4 3.1 7.8e-18 64.5 3.1 1.5 1 0 0 1 1 1 1 PHD-like zinc-binding domain JmjN PF02375.17 EMD59211.1 - 7.4e-14 51.4 0.8 2.2e-13 49.9 0.8 1.9 1 0 0 1 1 1 1 jmjN domain PHD PF00628.29 EMD59211.1 - 8 6.4 8.8 0.78 9.7 3.2 2.1 2 0 0 2 2 2 0 PHD-finger FAM184 PF15665.5 EMD59212.1 - 0.095 12.5 8.8 0.18 11.5 8.8 1.4 1 0 0 1 1 1 0 Family with sequence similarity 184, A and B YfhO PF09586.10 EMD59212.1 - 0.46 8.7 2.3 0.66 8.1 2.3 1.1 1 0 0 1 1 1 0 Bacterial membrane protein YfhO DUF4778 PF16008.5 EMD59212.1 - 2.4 8.1 9.4 7.2 6.6 9.4 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4778) F-box PF00646.33 EMD59213.1 - 2.9e-07 30.2 2.8 2.9e-07 30.2 2.8 1.9 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 EMD59213.1 - 1.7e-06 27.8 1.2 3.2e-06 26.9 1.2 1.5 1 0 0 1 1 1 1 F-box-like SAE2 PF08573.10 EMD59214.1 - 2.3e-31 109.2 0.5 2.3e-31 109.2 0.5 5.4 5 1 0 5 5 5 1 DNA repair protein endonuclease SAE2/CtIP C-terminus ZapB PF06005.12 EMD59214.1 - 0.00039 20.8 2.4 0.00039 20.8 2.4 5.5 4 1 0 4 4 4 1 Cell division protein ZapB DUF4951 PF16309.5 EMD59214.1 - 0.043 13.9 0.7 0.12 12.5 0.7 1.7 1 0 0 1 1 1 0 Domian of unknown function (DUF4951) Peptidase_M2 PF01401.18 EMD59214.1 - 2.4 6.7 17.5 3.9 6.0 17.5 1.2 1 0 0 1 1 1 0 Angiotensin-converting enzyme YabA PF06156.13 EMD59214.1 - 6.4 7.5 31.0 0.68 10.6 1.4 4.3 3 2 1 4 4 4 0 Initiation control protein YabA zf-RING_2 PF13639.6 EMD59215.1 - 1.1e-10 41.6 10.3 2e-10 40.8 10.3 1.4 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 EMD59215.1 - 1.1e-07 32.0 7.5 2.3e-07 31.0 7.5 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 EMD59215.1 - 2.1e-07 30.7 8.2 5e-07 29.5 8.2 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EMD59215.1 - 1.1e-06 28.4 11.4 6.3e-06 25.9 11.3 2.2 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EMD59215.1 - 2.9e-06 27.2 7.7 8.7e-06 25.7 4.9 2.4 1 1 1 2 2 2 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 EMD59215.1 - 4.6e-06 26.6 3.6 8.7e-06 25.7 3.6 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 EMD59215.1 - 1.5e-05 24.8 8.0 3.7e-05 23.5 8.0 1.7 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 EMD59215.1 - 1.7e-05 24.6 9.8 7.5e-05 22.5 9.9 1.9 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EMD59215.1 - 2.9e-05 23.9 10.0 6.4e-05 22.8 10.0 1.6 1 1 0 1 1 1 1 zinc-RING finger domain Radial_spoke PF04712.12 EMD59215.1 - 0.0012 17.9 10.3 0.0016 17.4 10.3 1.1 1 0 0 1 1 1 1 Radial spokehead-like protein zf-C3HC4_4 PF15227.6 EMD59215.1 - 0.0078 16.4 5.1 0.0078 16.4 5.1 2.1 2 0 0 2 2 1 1 zinc finger of C3HC4-type, RING zf-Nse PF11789.8 EMD59215.1 - 0.012 15.4 4.6 0.012 15.4 4.6 2.1 2 1 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit BSP_II PF05432.11 EMD59215.1 - 0.013 15.2 6.2 0.013 15.2 6.2 2.0 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) SDA1 PF05285.12 EMD59215.1 - 0.031 13.7 11.7 0.042 13.3 11.7 1.2 1 0 0 1 1 1 0 SDA1 FANCL_C PF11793.8 EMD59215.1 - 0.043 14.0 9.1 0.23 11.7 9.1 2.1 1 1 0 1 1 1 0 FANCL C-terminal domain PBP1_TM PF14812.6 EMD59215.1 - 0.065 13.6 16.9 0.53 10.7 9.5 2.4 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal TLP-20 PF06088.11 EMD59215.1 - 0.079 12.8 1.5 0.12 12.2 1.5 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) DUF2428 PF10350.9 EMD59215.1 - 0.081 12.2 0.9 0.13 11.4 0.9 1.3 1 0 0 1 1 1 0 Putative death-receptor fusion protein (DUF2428) RPN2_C PF18004.1 EMD59215.1 - 0.11 12.5 0.2 0.11 12.5 0.2 1.4 2 0 0 2 2 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Pox_Ag35 PF03286.14 EMD59215.1 - 0.15 11.8 7.3 0.035 13.9 3.4 1.9 2 0 0 2 2 2 0 Pox virus Ag35 surface protein DUF913 PF06025.12 EMD59215.1 - 0.16 11.0 0.4 0.2 10.6 0.4 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) zf-RING_10 PF16685.5 EMD59215.1 - 0.22 11.7 6.2 0.62 10.2 6.2 1.7 1 1 0 1 1 1 0 zinc RING finger of MSL2 zf-C3HC4_5 PF17121.5 EMD59215.1 - 0.66 9.9 6.8 1.5 8.8 6.0 2.0 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 EMD59215.1 - 0.8 9.4 7.8 2.2 8.0 7.8 1.8 1 1 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_4 PF14570.6 EMD59215.1 - 0.85 9.5 9.2 3.8 7.4 9.4 2.1 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain Sporozoite_P67 PF05642.11 EMD59215.1 - 0.9 7.5 4.2 1.2 7.1 4.2 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen CEBP_ZZ PF16366.5 EMD59215.1 - 0.92 9.8 6.8 1.9 8.8 6.8 1.5 1 0 0 1 1 1 0 Cytoplasmic polyadenylation element-binding protein ZZ domain DUF2457 PF10446.9 EMD59215.1 - 0.94 8.5 22.2 0.015 14.5 12.9 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2457) BUD22 PF09073.10 EMD59215.1 - 1.2 8.5 12.8 1.4 8.2 12.8 1.1 1 0 0 1 1 1 0 BUD22 RNase_H2_suC PF08615.11 EMD59215.1 - 1.4 9.1 5.3 7.5 6.7 5.3 2.0 1 1 0 1 1 1 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) CDC45 PF02724.14 EMD59215.1 - 1.6 7.0 10.8 2.1 6.6 10.8 1.1 1 0 0 1 1 1 0 CDC45-like protein RINGv PF12906.7 EMD59215.1 - 2.8 8.1 10.2 10 6.3 10.2 2.0 1 1 0 1 1 1 0 RING-variant domain Nop14 PF04147.12 EMD59215.1 - 3.1 5.9 17.7 4 5.5 17.7 1.1 1 0 0 1 1 1 0 Nop14-like family RRN3 PF05327.11 EMD59215.1 - 7 5.1 12.1 9.9 4.6 12.1 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 zf-C2H2_4 PF13894.6 EMD59215.1 - 7.8 7.6 10.3 8.8 7.5 0.5 3.7 2 1 2 4 4 3 0 C2H2-type zinc finger zf-RING_11 PF17123.5 EMD59215.1 - 8.1 6.3 11.6 0.73 9.6 6.3 2.1 2 0 0 2 2 2 0 RING-like zinc finger MARVEL PF01284.23 EMD59217.1 - 1.3e-13 51.2 13.0 1.6e-13 50.9 13.0 1.1 1 0 0 1 1 1 1 Membrane-associating domain DUF5316 PF17247.2 EMD59217.1 - 0.17 11.9 2.6 0.37 10.8 2.6 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5316) CaATP_NAI PF12515.8 EMD59217.1 - 0.34 10.5 1.1 2.3 7.9 0.0 2.2 2 0 0 2 2 2 0 Ca2+-ATPase N terminal autoinhibitory domain DUF3624 PF12292.8 EMD59217.1 - 0.48 10.9 6.6 11 6.6 1.8 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3624) DUF445 PF04286.12 EMD59218.1 - 0.0026 17.6 17.4 0.0032 17.3 7.3 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF445) DUF3053 PF11254.8 EMD59218.1 - 0.018 14.6 5.6 0.065 12.8 5.5 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF3053) Ge1_WD40 PF16529.5 EMD59218.1 - 0.055 12.4 0.1 0.28 10.1 0.0 2.0 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein HHH_2 PF12826.7 EMD59218.1 - 0.18 11.9 1.3 4.2 7.5 1.0 3.0 2 1 1 3 3 3 0 Helix-hairpin-helix motif DUF4533 PF15047.6 EMD59218.1 - 0.57 9.7 10.6 2.9 7.4 0.4 3.3 2 1 0 2 2 2 0 Protein of unknown function (DUF4533) VPS28 PF03997.12 EMD59218.1 - 0.87 9.2 4.8 0.28 10.8 1.4 1.9 2 0 0 2 2 2 0 VPS28 protein SesA PF17107.5 EMD59218.1 - 1.8 8.8 13.1 4 7.7 1.2 4.5 4 0 0 4 4 4 0 N-terminal domain on NACHT_NTPase and P-loop NTPases DUF1690 PF07956.11 EMD59218.1 - 8.3 6.8 24.1 0.38 11.2 2.6 4.4 4 0 0 4 4 4 0 Protein of Unknown function (DUF1690) Polysacc_deac_1 PF01522.21 EMD59219.1 - 3.9e-27 94.6 0.0 1e-26 93.3 0.0 1.6 2 0 0 2 2 2 1 Polysaccharide deacetylase Chitin_bind_1 PF00187.19 EMD59219.1 - 2.9e-13 50.0 41.2 9.1e-08 32.5 17.2 3.9 4 0 0 4 4 4 2 Chitin recognition protein Mif2_N PF15624.6 EMD59222.1 - 2.6e-39 135.0 3.3 2.6e-39 135.0 3.3 3.4 3 1 0 3 3 3 1 Kinetochore CENP-C fungal homologue, Mif2, N-terminal CENP-C_C PF11699.8 EMD59222.1 - 1.3e-24 86.2 0.4 2.2e-24 85.4 0.4 1.4 1 0 0 1 1 1 1 Mif2/CENP-C like Cupin_2 PF07883.11 EMD59222.1 - 0.011 15.4 0.2 0.024 14.4 0.2 1.4 1 0 0 1 1 1 0 Cupin domain DUF2070 PF09843.9 EMD59224.1 - 2.4 6.4 5.1 2.7 6.2 5.1 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Myb_DNA-binding PF00249.31 EMD59225.1 - 2.9e-14 53.0 2.7 5.9e-11 42.4 0.0 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EMD59225.1 - 2.3e-06 27.7 3.7 0.0022 18.2 0.0 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain AGOG PF09171.10 EMD59225.1 - 0.15 11.4 0.1 0.21 10.9 0.1 1.1 1 0 0 1 1 1 0 N-glycosylase/DNA lyase CAP_GLY PF01302.25 EMD59227.1 - 3.3e-25 87.9 0.1 4.6e-25 87.4 0.1 1.2 1 0 0 1 1 1 1 CAP-Gly domain Ubiquitin_2 PF14560.6 EMD59227.1 - 9.2e-21 74.1 0.0 1.4e-20 73.6 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-like domain ubiquitin PF00240.23 EMD59227.1 - 0.00044 20.0 0.0 0.00078 19.1 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family Amidohydro_1 PF01979.20 EMD59228.1 - 8e-22 78.0 0.0 1.2e-21 77.5 0.0 1.3 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EMD59228.1 - 3.6e-14 53.1 0.0 2.7e-06 27.1 0.0 2.4 2 0 0 2 2 2 2 Amidohydrolase family NOZZLE PF08744.10 EMD59228.1 - 0.013 15.0 0.1 0.02 14.4 0.1 1.2 1 0 0 1 1 1 0 Plant transcription factor NOZZLE Urease_alpha PF00449.20 EMD59228.1 - 0.031 14.6 0.5 0.06 13.7 0.5 1.5 1 0 0 1 1 1 0 Urease alpha-subunit, N-terminal domain Peptidase_M20 PF01546.28 EMD59229.1 - 2.2e-32 112.4 0.1 2.8e-32 112.1 0.1 1.1 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EMD59229.1 - 2.2e-06 27.5 0.0 4.6e-06 26.5 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 EMD59229.1 - 0.00087 19.0 0.0 0.0013 18.4 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 Glyco_hydro_61 PF03443.14 EMD59230.1 - 5.4e-52 176.7 0.0 6.7e-52 176.4 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 Glyco_hydro_85 PF03644.13 EMD59232.1 - 1.9e-82 277.1 0.0 2.9e-82 276.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 85 DHH PF01368.20 EMD59232.1 - 0.024 14.9 0.2 0.071 13.4 0.0 1.9 2 0 0 2 2 2 0 DHH family MAM PF00629.23 EMD59232.1 - 0.07 13.0 0.0 0.22 11.5 0.0 1.8 2 0 0 2 2 2 0 MAM domain, meprin/A5/mu ER_lumen_recept PF00810.18 EMD59233.1 - 1.1e-53 182.0 9.6 1.1e-53 182.0 9.6 1.4 2 0 0 2 2 2 1 ER lumen protein retaining receptor PQ-loop PF04193.14 EMD59233.1 - 0.16 11.8 15.0 0.76 9.6 0.2 4.4 4 1 1 5 5 5 0 PQ loop repeat BC10 PF06726.12 EMD59234.1 - 3.8e-12 46.3 9.7 5.4e-12 45.8 9.7 1.2 1 0 0 1 1 1 1 Bladder cancer-related protein BC10 BaffR-Tall_bind PF09256.10 EMD59234.1 - 7.9 6.3 6.5 4.3 7.2 0.7 2.6 3 0 0 3 3 3 0 BAFF-R, TALL-1 binding Peptidase_M1 PF01433.20 EMD59235.1 - 1.4e-84 283.0 3.3 2.7e-84 282.1 3.3 1.5 1 0 0 1 1 1 1 Peptidase family M1 domain ERAP1_C PF11838.8 EMD59235.1 - 1.9e-82 277.4 0.0 3.9e-82 276.3 0.0 1.6 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Peptidase_M1_N PF17900.1 EMD59235.1 - 2.1e-44 152.0 1.2 5.2e-43 147.4 0.3 2.5 2 1 0 2 2 2 1 Peptidase M1 N-terminal domain FAD_binding_3 PF01494.19 EMD59236.1 - 1.7e-56 192.0 0.0 5.4e-55 187.0 0.0 2.1 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.24 EMD59236.1 - 1.1e-06 28.5 0.0 2e-06 27.6 0.0 1.6 1 0 0 1 1 1 1 FAD dependent oxidoreductase Trp_halogenase PF04820.14 EMD59236.1 - 1.4e-05 24.2 0.0 2.1e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Tryptophan halogenase Pyr_redox_2 PF07992.14 EMD59236.1 - 1.8e-05 24.1 0.0 0.0014 17.9 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EMD59236.1 - 2.1e-05 24.7 0.0 5.5e-05 23.3 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 EMD59236.1 - 0.00015 21.1 0.0 0.00026 20.3 0.0 1.3 1 0 0 1 1 1 1 Thi4 family NAD_binding_9 PF13454.6 EMD59236.1 - 0.001 19.1 0.0 0.0025 17.8 0.0 1.7 2 0 0 2 2 2 1 FAD-NAD(P)-binding HI0933_like PF03486.14 EMD59236.1 - 0.0018 17.1 0.0 0.014 14.1 0.0 2.0 2 0 0 2 2 2 1 HI0933-like protein FAD_binding_2 PF00890.24 EMD59236.1 - 0.0064 15.6 0.0 0.0093 15.1 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 EMD59236.1 - 0.017 14.5 0.2 0.045 13.1 0.1 1.7 2 0 0 2 2 2 0 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EMD59236.1 - 0.049 12.9 0.0 0.075 12.3 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EMD59236.1 - 0.069 12.2 0.0 0.1 11.6 0.0 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein DUF2333 PF10095.9 EMD59236.1 - 0.2 10.6 0.0 0.3 10.0 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2333) DUF3818 PF12825.7 EMD59237.1 - 7.8e-61 206.0 0.2 2.1e-58 198.0 0.0 2.6 2 1 0 2 2 2 1 Domain of unknown function in PX-proteins (DUF3818) PXB PF12828.7 EMD59237.1 - 1.1e-38 132.2 0.0 2.3e-38 131.1 0.0 1.6 1 0 0 1 1 1 1 PX-associated TPD52 PF04201.15 EMD59237.1 - 0.02 14.5 0.2 0.28 10.8 0.1 2.4 2 0 0 2 2 2 0 Tumour protein D52 family Metal_resist PF13801.6 EMD59237.1 - 0.069 13.3 0.1 0.42 10.8 0.2 2.3 2 0 0 2 2 2 0 Heavy-metal resistance Big_6 PF17936.1 EMD59238.1 - 0.0074 16.5 1.5 0.2 12.0 0.0 3.0 3 0 0 3 3 3 1 Bacterial Ig domain Herpes_UL35 PF04496.12 EMD59238.1 - 0.013 15.8 0.1 0.033 14.5 0.1 1.6 1 0 0 1 1 1 0 Herpesvirus UL35 family Fungal_trans_2 PF11951.8 EMD59239.1 - 2.8e-07 29.7 0.9 6.5e-07 28.5 0.9 1.6 1 1 0 1 1 1 1 Fungal specific transcription factor domain Acyl-CoA_dh_1 PF00441.24 EMD59241.1 - 3.4e-37 128.0 0.2 4.6e-37 127.5 0.2 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 EMD59241.1 - 2.9e-17 62.6 0.1 5.7e-17 61.7 0.1 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 EMD59241.1 - 1e-11 45.3 0.0 1.7e-11 44.5 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 EMD59241.1 - 9.6e-09 35.9 0.0 5.2e-08 33.5 0.0 2.3 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain HpaB_N PF11794.8 EMD59241.1 - 0.061 13.0 0.0 0.1 12.3 0.0 1.3 1 0 0 1 1 1 0 4-hydroxyphenylacetate 3-hydroxylase N terminal DEAD_2 PF06733.15 EMD59241.1 - 0.12 12.0 0.2 0.2 11.3 0.2 1.2 1 0 0 1 1 1 0 DEAD_2 PH_BEACH PF14844.6 EMD59241.1 - 0.17 12.0 0.0 0.77 9.9 0.0 2.0 2 0 0 2 2 2 0 PH domain associated with Beige/BEACH PAM2 PF07145.15 EMD59242.1 - 0.11 12.3 0.1 0.36 10.6 0.1 2.0 1 0 0 1 1 1 0 Ataxin-2 C-terminal region Glyco_hydro_10 PF00331.20 EMD59243.1 - 1.6e-100 336.3 0.1 1.9e-100 336.1 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 10 Glyco_hydro_1 PF00232.18 EMD59243.1 - 0.00048 18.7 0.3 0.0014 17.1 0.1 1.8 2 0 0 2 2 2 1 Glycosyl hydrolase family 1 AP_endonuc_2 PF01261.24 EMD59243.1 - 0.003 17.0 0.0 0.061 12.8 0.0 2.2 2 0 0 2 2 2 1 Xylose isomerase-like TIM barrel DUF1079 PF06435.11 EMD59245.1 - 5.3 7.4 5.6 5 7.4 0.2 3.1 3 0 0 3 3 3 0 Repeat of unknown function (DUF1079) GMC_oxred_N PF00732.19 EMD59246.1 - 2.5e-53 181.4 0.0 3.3e-53 181.0 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EMD59246.1 - 2.6e-33 115.6 0.0 4.5e-33 114.8 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.24 EMD59246.1 - 0.00019 20.6 0.1 0.0031 16.6 0.0 2.1 2 0 0 2 2 2 1 FAD binding domain NAD_binding_8 PF13450.6 EMD59246.1 - 0.00035 20.8 1.3 0.00048 20.3 0.0 1.9 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 EMD59246.1 - 0.00081 18.5 0.0 0.0015 17.7 0.0 1.4 1 0 0 1 1 1 1 Lycopene cyclase protein DAO PF01266.24 EMD59246.1 - 0.00094 18.9 0.3 0.013 15.1 0.3 2.2 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EMD59246.1 - 0.0015 17.9 0.0 0.12 11.6 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EMD59246.1 - 0.069 12.4 0.0 0.17 11.1 0.0 1.6 1 0 0 1 1 1 0 Thi4 family HI0933_like PF03486.14 EMD59246.1 - 0.16 10.6 0.0 0.23 10.1 0.0 1.2 1 0 0 1 1 1 0 HI0933-like protein FAD_binding_3 PF01494.19 EMD59246.1 - 0.19 10.9 0.1 0.53 9.5 0.1 1.7 1 0 0 1 1 1 0 FAD binding domain Pkinase PF00069.25 EMD59249.1 - 4.3e-27 95.1 0.0 2.9e-12 46.5 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EMD59249.1 - 3.9e-12 46.0 0.0 2.6e-06 26.9 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase WD40 PF00400.32 EMD59250.1 - 2.9e-17 62.7 11.2 0.085 13.8 0.0 6.4 6 0 0 6 6 6 5 WD domain, G-beta repeat Nucleoporin_N PF08801.11 EMD59250.1 - 0.00011 21.2 1.8 2 7.1 0.3 3.5 2 1 1 3 3 3 3 Nup133 N terminal like ANAPC4_WD40 PF12894.7 EMD59250.1 - 0.0005 20.3 2.5 9.8 6.6 0.2 4.0 2 2 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain XRCC4 PF06632.12 EMD59252.1 - 0.03 13.2 20.1 0.046 12.6 17.4 2.1 1 1 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 DUF913 PF06025.12 EMD59252.1 - 4.2 6.3 8.3 6.7 5.6 8.3 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) 2-Hacid_dh_C PF02826.19 EMD59258.1 - 9.1e-51 171.7 0.0 1.5e-50 171.0 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EMD59258.1 - 6.9e-16 58.1 0.0 9.5e-16 57.7 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 EMD59258.1 - 0.00081 19.6 0.0 0.0021 18.3 0.0 1.6 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase AlaDh_PNT_C PF01262.21 EMD59258.1 - 0.0036 16.6 0.1 0.51 9.6 0.0 2.4 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain FH2 PF02181.23 EMD59260.1 - 4.5e-83 279.4 4.8 4.5e-83 279.4 4.8 1.8 2 0 0 2 2 2 1 Formin Homology 2 Domain Drf_GBD PF06371.13 EMD59260.1 - 1.5e-67 226.8 1.7 2.2e-67 226.3 0.0 2.2 2 1 1 3 3 3 1 Diaphanous GTPase-binding Domain Drf_FH3 PF06367.16 EMD59260.1 - 2.5e-50 170.8 2.0 2.5e-50 170.8 2.0 2.8 2 1 1 3 3 3 1 Diaphanous FH3 Domain peroxidase PF00141.23 EMD59262.1 - 5.2e-28 98.3 0.0 7.1e-28 97.9 0.0 1.2 1 0 0 1 1 1 1 Peroxidase Peroxidase_ext PF11895.8 EMD59262.1 - 0.0026 17.7 0.0 0.0064 16.4 0.0 1.6 1 0 0 1 1 1 1 Fungal peroxidase extension region UL97 PF06734.12 EMD59262.1 - 0.13 12.1 0.0 0.22 11.4 0.0 1.3 1 0 0 1 1 1 0 UL97 Amidohydro_2 PF04909.14 EMD59263.1 - 8.3e-18 65.2 0.1 1e-17 64.8 0.1 1.1 1 0 0 1 1 1 1 Amidohydrolase HATPase_c PF02518.26 EMD59264.1 - 1e-22 80.7 0.1 2.8e-22 79.3 0.1 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EMD59264.1 - 1.5e-17 63.7 0.0 4.3e-17 62.3 0.0 1.8 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 EMD59264.1 - 3.4e-12 46.2 0.0 1.3e-11 44.3 0.0 2.0 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain GAF PF01590.26 EMD59264.1 - 2e-09 38.2 0.0 6.9e-07 30.0 0.0 2.6 2 0 0 2 2 2 2 GAF domain GAF_3 PF13492.6 EMD59264.1 - 0.0035 17.7 0.0 0.014 15.7 0.0 2.0 2 0 0 2 2 2 1 GAF domain GAF_2 PF13185.6 EMD59264.1 - 0.017 15.4 0.2 0.095 13.0 0.0 2.5 3 1 0 3 3 3 0 GAF domain DUF2011 PF09428.10 EMD59265.1 - 1.8e-21 76.2 0.4 9.4e-21 73.9 0.0 2.1 2 1 0 2 2 2 1 Fungal protein of unknown function (DUF2011) DUF3340 PF11818.8 EMD59265.1 - 8.9e-05 22.7 10.7 0.00016 21.9 10.7 1.4 1 0 0 1 1 1 1 C-terminal domain of tail specific protease (DUF3340) AAA_11 PF13086.6 EMD59265.1 - 2.5 7.8 12.8 3 7.6 11.9 1.5 2 0 0 2 2 2 0 AAA domain NPR3 PF03666.13 EMD59265.1 - 3 6.5 10.5 4.4 6.0 10.5 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 LYRIC PF15686.5 EMD59265.1 - 5.1 6.5 20.7 6.7 6.1 20.7 1.1 1 0 0 1 1 1 0 Lysine-rich CEACAM1 co-isolated protein family Pannexin_like PF12534.8 EMD59265.1 - 5.7 5.9 6.6 7.6 5.5 6.6 1.2 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 CemA PF03040.14 EMD59265.1 - 7.8 6.4 5.6 12 5.8 5.6 1.2 1 0 0 1 1 1 0 CemA family DUF4337 PF14235.6 EMD59265.1 - 9.5 6.3 10.6 23 5.0 10.6 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) HET PF06985.11 EMD59266.1 - 9.9e-08 32.5 0.1 0.0005 20.4 0.0 2.1 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) DNA_III_psi PF03603.13 EMD59267.1 - 0.071 13.4 0.0 0.1 12.9 0.0 1.2 1 0 0 1 1 1 0 DNA polymerase III psi subunit Mso1_Sec1_bdg PF14475.6 EMD59268.1 - 7.9e-19 67.0 0.1 7.9e-19 67.0 0.1 1.7 2 0 0 2 2 2 1 Sec1-binding region of Mso1 RabGAP-TBC PF00566.18 EMD59269.1 - 4.3e-39 134.4 6.0 9.7e-39 133.2 6.0 1.6 1 1 0 1 1 1 1 Rab-GTPase-TBC domain PH_RBD PF12068.8 EMD59269.1 - 6.8e-07 28.9 1.4 0.00072 19.1 3.1 3.1 2 1 0 2 2 2 1 Rab-binding domain (RBD) TPR_12 PF13424.6 EMD59271.1 - 1.5e-37 127.7 22.5 1.3e-14 54.2 2.6 3.8 1 1 3 4 4 4 4 Tetratricopeptide repeat TPR_10 PF13374.6 EMD59271.1 - 2.3e-29 100.4 6.2 8.1e-09 35.1 0.1 5.7 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_7 PF13176.6 EMD59271.1 - 1.6e-10 40.3 7.4 0.0017 18.2 0.2 4.5 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 EMD59271.1 - 2.7e-09 36.4 8.7 0.01 15.9 0.4 4.9 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 EMD59271.1 - 1.8e-08 33.9 10.4 0.0031 17.3 0.8 4.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_MalT PF17874.1 EMD59271.1 - 1.7e-06 27.7 4.6 0.00042 19.8 0.8 2.2 1 1 1 2 2 2 2 MalT-like TPR region TPR_14 PF13428.6 EMD59271.1 - 5.6e-05 23.6 2.1 28 5.9 0.0 4.9 3 1 1 4 4 4 0 Tetratricopeptide repeat NB-ARC PF00931.22 EMD59271.1 - 0.00019 20.7 0.1 0.0044 16.3 0.1 2.4 1 1 0 1 1 1 1 NB-ARC domain TPR_16 PF13432.6 EMD59271.1 - 0.00096 19.8 0.5 6.8 7.4 0.0 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 EMD59271.1 - 0.018 15.6 5.0 0.14 12.7 1.1 3.3 1 1 2 3 3 3 0 Tetratricopeptide repeat Peripla_BP_2 PF01497.18 EMD59271.1 - 0.021 14.4 0.4 4.5 6.7 0.1 3.0 1 1 1 2 2 2 0 Periplasmic binding protein EspB PF05802.11 EMD59271.1 - 0.11 12.5 0.3 3.7 7.5 0.3 2.3 1 1 0 1 1 1 0 Enterobacterial EspB protein PPR PF01535.20 EMD59271.1 - 0.15 12.4 0.2 16 6.0 0.0 3.5 2 0 0 2 2 2 0 PPR repeat DUF4145 PF13643.6 EMD59271.1 - 0.19 11.9 0.4 1.5 9.0 0.4 2.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4145) TPR_8 PF13181.6 EMD59271.1 - 0.41 11.0 9.1 9 6.8 0.7 4.1 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 EMD59271.1 - 0.56 11.0 2.6 29 5.6 0.2 3.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_3 PF07720.12 EMD59271.1 - 0.89 9.6 4.4 0.32 11.0 0.3 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EMD59271.1 - 1.1 9.5 5.8 5.7 7.2 1.7 3.4 1 1 2 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 EMD59271.1 - 1.4 8.7 5.1 3.7 7.3 0.3 3.2 3 0 0 3 3 3 0 TPR repeat HET PF06985.11 EMD59272.1 - 1.6e-05 25.3 7.6 0.17 12.3 0.1 3.4 2 1 1 3 3 3 3 Heterokaryon incompatibility protein (HET) HET PF06985.11 EMD59274.1 - 1.2e-15 58.1 1.2 1.2e-15 58.1 1.2 1.0 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) W2 PF02020.18 EMD59274.1 - 0.055 13.6 0.0 0.085 13.0 0.0 1.4 1 1 0 1 1 1 0 eIF4-gamma/eIF5/eIF2-epsilon UCH PF00443.29 EMD59275.1 - 7.1e-24 84.7 0.1 1.4e-23 83.7 0.1 1.4 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EMD59275.1 - 2.5e-13 50.3 0.0 1.9e-10 40.8 0.0 2.1 1 1 1 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase COX4 PF02936.14 EMD59276.1 - 2.1e-41 141.2 0.2 2.9e-41 140.7 0.2 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase subunit IV DUF3106 PF11304.8 EMD59276.1 - 0.0057 17.1 2.3 0.0057 17.1 2.3 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF3106) MgtE_N PF03448.17 EMD59276.1 - 0.063 13.9 0.0 0.1 13.2 0.0 1.2 1 0 0 1 1 1 0 MgtE intracellular N domain TraE PF05309.11 EMD59276.1 - 0.098 12.0 0.1 0.24 10.8 0.0 1.6 2 0 0 2 2 2 0 TraE protein Gp_dh_C PF02800.20 EMD59277.1 - 1.5e-71 239.1 0.1 2.1e-71 238.6 0.1 1.2 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.24 EMD59277.1 - 7.7e-39 132.1 0.1 1.7e-38 131.0 0.1 1.6 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain DapB_N PF01113.20 EMD59277.1 - 0.0087 16.2 0.1 0.038 14.1 0.0 2.1 2 0 0 2 2 2 1 Dihydrodipicolinate reductase, N-terminus Hist_deacetyl PF00850.19 EMD59279.1 - 2.8e-90 302.9 0.0 4.2e-90 302.3 0.0 1.3 1 0 0 1 1 1 1 Histone deacetylase domain Arb2 PF09757.9 EMD59279.1 - 1.1e-85 286.9 0.1 1.5e-85 286.5 0.1 1.1 1 0 0 1 1 1 1 Arb2 domain Cyclin PF08613.11 EMD59281.1 - 1.6e-29 103.4 0.0 3.9e-29 102.1 0.0 1.6 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 EMD59281.1 - 0.0002 21.1 0.1 0.00032 20.4 0.1 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Arm PF00514.23 EMD59283.1 - 3.1e-12 46.1 7.1 0.0018 18.2 0.0 8.0 9 0 0 9 9 9 2 Armadillo/beta-catenin-like repeat HEAT PF02985.22 EMD59283.1 - 0.00014 21.8 4.5 16 6.0 0.0 6.7 6 0 0 6 6 6 2 HEAT repeat HEAT_EZ PF13513.6 EMD59283.1 - 0.015 15.8 12.1 1.4 9.5 0.1 6.3 9 0 0 9 9 9 0 HEAT-like repeat MethyTransf_Reg PF10119.9 EMD59283.1 - 0.017 15.8 0.0 0.062 14.0 0.0 1.9 1 0 0 1 1 1 0 Predicted methyltransferase regulatory domain IFRD PF05004.13 EMD59283.1 - 0.051 12.7 1.9 0.078 12.1 0.0 2.2 3 0 0 3 3 3 0 Interferon-related developmental regulator (IFRD) IBN_N PF03810.19 EMD59283.1 - 0.079 12.9 0.1 0.41 10.6 0.0 2.2 2 0 0 2 2 2 0 Importin-beta N-terminal domain NusB PF01029.18 EMD59283.1 - 0.2 11.9 0.3 38 4.5 0.0 3.0 2 1 0 2 2 2 0 NusB family Coprogen_oxidas PF01218.18 EMD59284.1 - 2.2e-144 479.7 0.1 2.6e-144 479.4 0.1 1.0 1 0 0 1 1 1 1 Coproporphyrinogen III oxidase Atg8 PF02991.16 EMD59285.1 - 2.4e-51 172.3 0.3 2.8e-51 172.0 0.3 1.0 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.13 EMD59285.1 - 3.2e-06 27.5 0.0 3.7e-06 27.2 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 NCE101 PF11654.8 EMD59286.1 - 1.6e-08 34.1 0.0 2.2e-08 33.7 0.0 1.2 1 0 0 1 1 1 1 Non-classical export protein 1 DUF4633 PF15464.6 EMD59286.1 - 0.016 15.3 0.1 0.018 15.2 0.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4633) DNA_pol3_gamma3 PF12169.8 EMD59286.1 - 0.063 13.2 0.0 0.063 13.2 0.0 1.0 1 0 0 1 1 1 0 DNA polymerase III subunits gamma and tau domain III FoP_duplication PF13865.6 EMD59288.1 - 0.43 11.2 13.5 0.76 10.4 13.5 1.4 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 Mucin PF01456.17 EMD59289.1 - 0.059 13.4 18.9 0.077 13.0 18.9 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein RIFIN PF02009.16 EMD59289.1 - 0.18 11.7 1.6 0.22 11.4 1.6 1.0 1 0 0 1 1 1 0 Rifin MGC-24 PF05283.11 EMD59289.1 - 0.23 11.9 7.7 0.29 11.6 7.7 1.1 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin FSA_C PF10479.9 EMD59289.1 - 0.76 7.8 5.2 0.71 7.9 5.2 1.0 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus ATP-synt_ab PF00006.25 EMD59290.1 - 7.9e-60 202.1 0.0 1.3e-59 201.4 0.0 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 EMD59290.1 - 1.4e-22 80.0 1.8 3e-22 78.9 1.0 2.1 2 0 0 2 2 1 1 ATP synthase alpha/beta family, beta-barrel domain RsgA_GTPase PF03193.16 EMD59290.1 - 0.011 15.6 0.8 0.025 14.5 0.0 1.9 3 0 0 3 3 3 0 RsgA GTPase NB-ARC PF00931.22 EMD59290.1 - 0.011 14.9 0.3 0.06 12.5 0.1 2.0 2 0 0 2 2 2 0 NB-ARC domain ATPase_2 PF01637.18 EMD59290.1 - 0.022 14.7 0.0 0.054 13.4 0.0 1.6 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_16 PF13191.6 EMD59290.1 - 0.023 15.1 0.5 0.085 13.2 0.1 2.1 2 1 0 2 2 2 0 AAA ATPase domain AAA PF00004.29 EMD59290.1 - 0.033 14.6 0.4 1.8 9.0 0.1 2.8 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 EMD59290.1 - 0.037 14.0 0.0 0.09 12.7 0.0 1.7 1 0 0 1 1 1 0 NACHT domain T3SS_ATPase_C PF18269.1 EMD59290.1 - 0.038 13.8 1.0 0.25 11.2 1.0 2.2 1 1 0 1 1 1 0 T3SS EscN ATPase C-terminal domain AAA_19 PF13245.6 EMD59290.1 - 0.049 14.0 0.8 0.49 10.7 0.2 2.2 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 EMD59290.1 - 0.053 12.9 0.2 0.11 11.8 0.2 1.5 1 0 0 1 1 1 0 KaiC RNA_helicase PF00910.22 EMD59290.1 - 0.093 13.1 0.0 0.2 12.1 0.0 1.6 1 0 0 1 1 1 0 RNA helicase Omega_Repress PF07764.11 EMD59291.1 - 0.1 13.2 0.4 0.28 11.8 0.4 1.7 2 0 0 2 2 2 0 Omega Transcriptional Repressor CFIA_Pcf11 PF11526.8 EMD59292.1 - 8.8e-05 22.9 3.7 0.0013 19.2 3.7 2.4 1 1 0 1 1 1 1 Subunit of cleavage factor IA Pcf11 VHS PF00790.19 EMD59292.1 - 0.0011 18.9 0.0 0.0037 17.1 0.0 1.8 2 0 0 2 2 2 1 VHS domain CTD_bind PF04818.13 EMD59292.1 - 0.0022 18.8 0.0 0.0063 17.3 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase II-binding domain. Prok-RING_1 PF14446.6 EMD59292.1 - 0.066 13.1 1.1 0.22 11.5 0.1 2.0 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 zf-C2HC_2 PF13913.6 EMD59292.1 - 0.59 10.1 4.2 14 5.7 0.4 2.6 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf_UBZ PF18439.1 EMD59292.1 - 2 8.1 7.0 1.5 8.4 2.0 2.7 2 1 0 2 2 2 0 Ubiquitin-Binding Zinc Finger Med26 PF08711.11 EMD59293.1 - 1.4e-09 37.9 0.0 2.7e-09 36.9 0.0 1.6 1 0 0 1 1 1 1 TFIIS helical bundle-like domain Iron_permease PF04120.12 EMD59293.1 - 0.027 14.3 1.5 0.053 13.3 1.5 1.4 1 0 0 1 1 1 0 Low affinity iron permease Pectate_lyase_3 PF12708.7 EMD59294.1 - 2.1e-86 289.2 17.9 2e-73 246.8 7.6 3.8 4 0 0 4 4 4 3 Pectate lyase superfamily protein End_N_terminal PF12218.8 EMD59294.1 - 5e-06 26.1 1.3 0.088 12.5 0.1 3.1 3 0 0 3 3 3 2 N terminal extension of bacteriophage endosialidase Tom5 PF10642.9 EMD59295.1 - 3.6e-16 58.9 0.5 4.6e-16 58.6 0.5 1.2 1 0 0 1 1 1 1 Mitochondrial import receptor subunit or translocase Nup54 PF13874.6 EMD59296.1 - 2.9e-39 134.4 1.3 2.9e-39 134.4 1.3 2.9 4 1 0 4 4 4 1 Nucleoporin complex subunit 54 Nucleoporin_FG PF13634.6 EMD59296.1 - 4.1e-10 40.4 46.7 7.6e-08 33.1 28.9 2.5 1 1 1 2 2 2 2 Nucleoporin FG repeat region Nup54_57_C PF18570.1 EMD59296.1 - 4.2e-05 23.0 5.8 9.4e-05 21.9 5.8 1.6 1 0 0 1 1 1 1 NUP57/Nup54 C-terminal domain DUF724 PF05266.14 EMD59296.1 - 0.73 9.6 9.0 0.1 12.4 4.6 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF724) FapA PF03961.13 EMD59296.1 - 7.9 5.0 7.7 24 3.4 7.2 1.9 1 1 1 2 2 2 0 Flagellar Assembly Protein A CHCH PF06747.13 EMD59297.1 - 8.1e-06 25.8 6.0 8.1e-06 25.8 6.0 2.6 3 0 0 3 3 3 2 CHCH domain CX9C PF16860.5 EMD59297.1 - 0.00066 19.6 4.4 0.00066 19.6 4.4 2.2 2 0 0 2 2 2 1 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Kre28 PF17097.5 EMD59297.1 - 0.076 12.0 0.1 0.088 11.7 0.1 1.1 1 0 0 1 1 1 0 Spindle pole body component Pet191_N PF10203.9 EMD59297.1 - 0.6 10.5 11.1 5.4 7.4 6.3 3.0 1 1 2 3 3 3 0 Cytochrome c oxidase assembly protein PET191 Cmc1 PF08583.10 EMD59297.1 - 0.71 9.9 14.3 1.8 8.6 4.8 2.3 1 1 1 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like UCR_hinge PF02320.16 EMD59297.1 - 2.5 8.4 9.8 1.7 8.9 4.9 2.7 1 1 1 2 2 2 0 Ubiquinol-cytochrome C reductase hinge protein NDUF_B7 PF05676.13 EMD59297.1 - 4 7.2 10.0 2 8.2 4.0 2.3 1 1 0 2 2 2 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) Apc15p PF05841.11 EMD59298.1 - 1.3e-12 48.6 0.3 1.3e-12 48.6 0.3 2.9 1 1 1 2 2 2 1 Apc15p protein Cwf_Cwc_15 PF04889.12 EMD59298.1 - 2.9 7.6 27.3 0.038 13.7 14.9 2.2 1 1 1 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Mpp10 PF04006.12 EMD59298.1 - 5.3 5.4 26.6 7.5 4.9 26.6 1.1 1 0 0 1 1 1 0 Mpp10 protein AAA_2 PF07724.14 EMD59303.1 - 1.6e-38 132.5 0.0 4.3e-38 131.1 0.0 1.8 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA PF00004.29 EMD59303.1 - 2.1e-15 57.3 0.0 8.5e-15 55.4 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.9 EMD59303.1 - 6.7e-09 35.7 0.2 1.8e-08 34.3 0.2 1.7 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.14 EMD59303.1 - 1.6e-05 24.9 0.0 3.3e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EMD59303.1 - 0.00028 21.2 0.8 0.0083 16.4 0.8 2.7 1 1 0 1 1 1 1 AAA domain AAA_7 PF12775.7 EMD59303.1 - 0.0019 17.7 0.0 0.0034 16.9 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_14 PF13173.6 EMD59303.1 - 0.0024 17.9 0.0 0.0052 16.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EMD59303.1 - 0.0046 17.5 1.0 0.025 15.1 0.1 2.4 2 0 0 2 2 2 1 AAA domain Sigma54_activat PF00158.26 EMD59303.1 - 0.0049 16.6 0.2 0.037 13.7 0.2 2.2 1 1 0 1 1 1 1 Sigma-54 interaction domain IstB_IS21 PF01695.17 EMD59303.1 - 0.01 15.6 0.0 0.023 14.4 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein MCM PF00493.23 EMD59303.1 - 0.02 14.0 0.1 0.037 13.1 0.1 1.3 1 0 0 1 1 1 0 MCM P-loop domain AAA_16 PF13191.6 EMD59303.1 - 0.029 14.7 1.9 0.11 12.9 0.1 2.7 1 1 1 3 3 3 0 AAA ATPase domain AAA_24 PF13479.6 EMD59303.1 - 0.03 14.0 0.1 0.054 13.2 0.1 1.4 1 0 0 1 1 1 0 AAA domain RuvB_N PF05496.12 EMD59303.1 - 0.031 14.0 0.0 0.08 12.7 0.0 1.7 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain RNA_helicase PF00910.22 EMD59303.1 - 0.034 14.5 0.0 0.07 13.5 0.0 1.5 1 0 0 1 1 1 0 RNA helicase DEAD PF00270.29 EMD59303.1 - 0.045 13.5 0.1 1 9.1 0.1 2.4 2 0 0 2 2 2 0 DEAD/DEAH box helicase TsaE PF02367.17 EMD59303.1 - 0.051 13.6 0.1 0.099 12.6 0.1 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_6 PF12774.7 EMD59303.1 - 0.054 12.5 0.1 0.093 11.7 0.1 1.3 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region Rad17 PF03215.15 EMD59303.1 - 0.08 12.9 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain IPT PF01745.16 EMD59303.1 - 0.083 12.3 0.1 0.16 11.3 0.1 1.4 1 0 0 1 1 1 0 Isopentenyl transferase T2SSE PF00437.20 EMD59303.1 - 0.085 11.9 0.0 0.15 11.1 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein ATPase PF06745.13 EMD59303.1 - 0.1 11.9 0.0 0.29 10.5 0.0 1.7 1 0 0 1 1 1 0 KaiC Sigma54_activ_2 PF14532.6 EMD59303.1 - 0.12 12.5 0.0 0.51 10.5 0.0 2.0 2 0 0 2 2 2 0 Sigma-54 interaction domain Mg_chelatase PF01078.21 EMD59303.1 - 0.26 10.6 2.2 0.46 9.8 0.2 2.3 2 1 1 3 3 3 0 Magnesium chelatase, subunit ChlI Alpha-amylase_C PF02806.18 EMD59304.1 - 6.5e-28 97.1 0.1 1.6e-27 95.8 0.1 1.7 1 0 0 1 1 1 1 Alpha amylase, C-terminal all-beta domain CBM_48 PF02922.18 EMD59304.1 - 5.8e-16 58.6 0.1 1.2e-15 57.6 0.1 1.6 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Alpha-amylase PF00128.24 EMD59304.1 - 1.7e-12 47.6 0.3 2e-09 37.5 0.1 2.3 1 1 1 2 2 2 2 Alpha amylase, catalytic domain Suc_Fer-like PF06999.12 EMD59305.1 - 1.1e-54 185.3 0.0 2e-54 184.4 0.0 1.5 1 0 0 1 1 1 1 Sucrase/ferredoxin-like tRNA-synt_1 PF00133.22 EMD59305.1 - 8.1e-47 159.8 0.1 3.4e-21 75.1 0.2 6.1 2 1 3 5 5 5 5 tRNA synthetases class I (I, L, M and V) tRNA-synt_1_2 PF13603.6 EMD59305.1 - 1.9e-40 138.3 0.0 3.2e-40 137.6 0.0 1.4 1 0 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1g PF09334.11 EMD59305.1 - 2.7e-25 89.0 2.7 3.2e-20 72.3 0.0 4.6 5 1 1 6 6 6 2 tRNA synthetases class I (M) Anticodon_1 PF08264.13 EMD59305.1 - 4.7e-10 39.6 0.1 9.5e-10 38.6 0.1 1.5 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA DNA_ligase_ZBD PF03119.16 EMD59305.1 - 0.0083 16.1 0.0 0.025 14.6 0.0 1.9 1 0 0 1 1 1 1 NAD-dependent DNA ligase C4 zinc finger domain tRNA-synt_1e PF01406.19 EMD59305.1 - 0.026 13.9 0.0 2.6 7.3 0.0 2.3 2 0 0 2 2 2 0 tRNA synthetases class I (C) catalytic domain zf-ribbon_3 PF13248.6 EMD59305.1 - 0.06 12.8 2.3 7.4 6.1 0.2 2.6 2 0 0 2 2 2 0 zinc-ribbon domain AA_permease_2 PF13520.6 EMD59306.1 - 6.4e-64 216.3 36.7 1.1e-63 215.5 36.7 1.4 1 1 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EMD59306.1 - 6.1e-31 107.5 23.4 6.1e-31 107.5 23.4 2.1 2 1 0 2 2 2 1 Amino acid permease MadM PF03818.13 EMD59306.1 - 1.7 8.5 8.2 0.24 11.3 0.4 3.5 3 0 0 3 3 3 0 Malonate/sodium symporter MadM subunit DUF308 PF03729.13 EMD59307.1 - 0.037 14.4 1.0 0.037 14.4 1.0 2.5 3 0 0 3 3 3 0 Short repeat of unknown function (DUF308) PIG-P PF08510.12 EMD59307.1 - 0.92 9.4 3.8 2.2 8.2 3.8 1.6 1 0 0 1 1 1 0 PIG-P DUF2231 PF09990.9 EMD59307.1 - 1.6 9.2 6.4 13 6.3 1.9 2.7 2 1 0 2 2 2 0 Predicted membrane protein (DUF2231) DUF1980 PF09323.10 EMD59307.1 - 6.9 6.5 6.8 0.49 10.3 0.7 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) Aminotran_5 PF00266.19 EMD59309.1 - 2.8e-29 102.2 0.0 4.8e-17 62.0 0.0 2.1 1 1 1 2 2 2 2 Aminotransferase class-V Aconitase PF00330.20 EMD59310.1 - 4.1e-112 375.5 0.3 4.7e-111 372.0 0.3 2.3 1 1 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 EMD59310.1 - 2.3e-26 92.7 0.0 4.4e-26 91.7 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain Mito_carr PF00153.27 EMD59312.1 - 1.2e-32 111.6 1.3 1.9e-15 56.5 0.1 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Ras PF00071.22 EMD59313.1 - 2.9e-65 218.8 0.6 3.3e-65 218.6 0.6 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMD59313.1 - 1e-35 122.5 0.1 1.7e-35 121.9 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMD59313.1 - 2.5e-16 59.6 0.1 2.9e-16 59.4 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EMD59313.1 - 2.9e-05 24.0 0.3 0.15 12.0 0.0 2.3 1 1 1 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EMD59313.1 - 3.8e-05 23.7 0.0 0.00012 22.1 0.0 1.7 1 1 1 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EMD59313.1 - 6.5e-05 22.5 0.4 0.00016 21.3 0.4 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EMD59313.1 - 0.00032 20.1 0.1 0.0004 19.8 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA PF00004.29 EMD59313.1 - 0.00044 20.7 0.0 0.2 12.1 0.0 2.2 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) SRPRB PF09439.10 EMD59313.1 - 0.00073 19.0 0.0 0.001 18.5 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit FeoB_N PF02421.18 EMD59313.1 - 0.0013 18.3 0.0 0.0071 15.9 0.0 1.9 1 1 0 1 1 1 1 Ferrous iron transport protein B AAA_16 PF13191.6 EMD59313.1 - 0.0085 16.5 0.0 0.012 16.0 0.0 1.3 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EMD59313.1 - 0.041 14.2 0.0 0.085 13.1 0.0 1.9 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EMD59313.1 - 0.053 13.3 0.2 0.17 11.6 0.1 1.9 1 1 0 1 1 1 0 P-loop containing region of AAA domain AAA_5 PF07728.14 EMD59313.1 - 0.059 13.4 0.1 0.16 12.0 0.0 1.9 1 1 0 2 2 2 0 AAA domain (dynein-related subfamily) TniB PF05621.11 EMD59313.1 - 0.061 12.7 0.0 0.16 11.4 0.0 1.7 2 0 0 2 2 2 0 Bacterial TniB protein AAA_7 PF12775.7 EMD59313.1 - 0.064 12.8 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region VirE PF05272.11 EMD59313.1 - 0.079 12.7 0.1 0.19 11.5 0.0 1.7 2 0 0 2 2 2 0 Virulence-associated protein E Septin PF00735.18 EMD59313.1 - 0.11 11.7 0.0 0.23 10.7 0.0 1.4 1 0 0 1 1 1 0 Septin AAA_25 PF13481.6 EMD59313.1 - 0.12 11.9 0.1 1 8.9 0.0 2.2 2 1 0 2 2 2 0 AAA domain MFS_1 PF07690.16 EMD59314.1 - 5.9e-30 104.4 31.8 1.2e-22 80.3 15.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 EMD59314.1 - 5.5e-09 35.4 0.2 0.00012 21.1 0.1 2.7 2 2 1 3 3 3 2 MFS_1 like family MFS_2 PF13347.6 EMD59314.1 - 1.7e-06 26.9 12.9 0.013 14.0 5.1 3.2 3 0 0 3 3 3 3 MFS/sugar transport protein Sugar_tr PF00083.24 EMD59314.1 - 3.7e-05 22.8 10.9 0.0055 15.6 3.7 2.8 3 1 0 3 3 3 2 Sugar (and other) transporter TRI12 PF06609.13 EMD59314.1 - 0.00017 20.2 1.0 0.00017 20.2 1.0 1.9 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) OATP PF03137.20 EMD59314.1 - 0.0035 15.7 4.2 13 3.9 6.3 3.4 2 1 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family ACOX PF01756.19 EMD59314.1 - 0.051 13.1 0.0 0.15 11.6 0.0 1.7 2 0 0 2 2 2 0 Acyl-CoA oxidase Sugar_tr PF00083.24 EMD59315.1 - 1.9e-78 264.3 22.1 2.2e-78 264.1 22.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD59315.1 - 2.1e-14 53.2 43.8 6.3e-09 35.2 7.0 2.3 1 1 2 3 3 3 3 Major Facilitator Superfamily EF-hand_4 PF12763.7 EMD59316.1 - 8.5e-35 118.9 0.0 1.3e-13 50.8 0.0 3.9 4 0 0 4 4 4 3 Cytoskeletal-regulatory complex EF hand EF-hand_7 PF13499.6 EMD59316.1 - 1.1e-08 35.4 0.0 0.0043 17.5 0.0 3.7 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 EMD59316.1 - 7.5e-05 22.0 0.1 0.77 9.5 0.0 4.8 5 0 0 5 5 5 1 EF hand UBA PF00627.31 EMD59316.1 - 0.00016 21.5 0.0 0.00031 20.6 0.0 1.4 1 0 0 1 1 1 1 UBA/TS-N domain EF-hand_8 PF13833.6 EMD59316.1 - 0.00017 21.3 0.1 10 6.1 0.0 4.7 5 0 0 5 5 4 0 EF-hand domain pair Macoilin PF09726.9 EMD59316.1 - 0.00027 19.7 12.5 0.00027 19.7 12.5 2.1 2 0 0 2 2 2 1 Macoilin family EF-hand_6 PF13405.6 EMD59316.1 - 0.00028 20.6 0.5 61 3.9 0.0 5.4 5 0 0 5 5 5 0 EF-hand domain BicD PF09730.9 EMD59316.1 - 0.00032 19.3 21.7 0.00068 18.2 21.7 1.5 1 0 0 1 1 1 1 Microtubule-associated protein Bicaudal-D EzrA PF06160.12 EMD59316.1 - 0.0015 16.8 17.4 0.0015 16.8 17.4 1.6 1 1 1 2 2 2 1 Septation ring formation regulator, EzrA Tup_N PF08581.10 EMD59316.1 - 0.0024 18.1 4.6 0.0024 18.1 4.6 3.4 2 1 1 3 3 3 1 Tup N-terminal DUF1192 PF06698.11 EMD59316.1 - 0.031 14.3 0.2 0.14 12.2 0.2 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) PKcGMP_CC PF16808.5 EMD59316.1 - 0.052 13.4 0.2 0.13 12.2 0.2 1.6 1 0 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase TPR_MLP1_2 PF07926.12 EMD59316.1 - 0.069 13.2 28.0 0.12 12.5 14.7 2.4 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Spc7 PF08317.11 EMD59316.1 - 0.11 11.3 31.3 0.14 11.0 18.4 2.5 2 1 1 3 3 3 0 Spc7 kinetochore protein GAS PF13851.6 EMD59316.1 - 0.18 11.1 31.8 0.73 9.2 15.6 2.2 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding CENP-F_leu_zip PF10473.9 EMD59316.1 - 0.24 11.4 28.8 0.042 13.9 9.7 2.7 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Fib_alpha PF08702.10 EMD59316.1 - 0.24 11.6 23.3 0.023 14.9 10.2 2.4 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family APG17 PF04108.12 EMD59316.1 - 0.26 10.4 16.5 0.4 9.8 16.5 1.2 1 0 0 1 1 1 0 Autophagy protein Apg17 Fez1 PF06818.15 EMD59316.1 - 0.29 11.6 28.0 0.16 12.4 21.7 2.2 1 1 1 2 2 2 0 Fez1 DUF1664 PF07889.12 EMD59316.1 - 0.62 10.1 19.8 0.35 10.9 8.8 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) ADIP PF11559.8 EMD59316.1 - 0.66 10.0 35.8 0.62 10.1 16.1 3.0 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding TACC_C PF05010.14 EMD59316.1 - 1 9.1 21.0 4.6 7.0 5.6 2.3 1 1 1 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal FPP PF05911.11 EMD59316.1 - 1.2 7.3 26.0 1.3 7.1 12.3 2.1 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil Filament PF00038.21 EMD59316.1 - 1.5 8.3 28.0 0.93 9.0 15.1 2.1 1 1 1 2 2 2 0 Intermediate filament protein APG6_N PF17675.1 EMD59316.1 - 1.9 9.0 28.8 5.4 7.5 19.1 3.0 1 1 1 2 2 2 0 Apg6 coiled-coil region PI3K_P85_iSH2 PF16454.5 EMD59316.1 - 2.2 7.8 20.3 3 7.4 19.2 1.7 1 1 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain CALCOCO1 PF07888.11 EMD59316.1 - 2.8 6.7 26.0 5.1 5.8 26.0 1.3 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like CCDC144C PF14915.6 EMD59316.1 - 3.4 6.7 28.4 0.19 10.8 10.8 2.1 1 1 1 2 2 2 0 CCDC144C protein coiled-coil region PRKG1_interact PF15898.5 EMD59316.1 - 3.6 8.6 31.2 0.3 12.0 10.5 3.1 1 1 0 2 2 2 0 cGMP-dependent protein kinase interacting domain SPATA1_C PF15743.5 EMD59316.1 - 4.7 7.3 22.8 8.3 6.5 22.8 1.3 1 0 0 1 1 1 0 Spermatogenesis-associated C-terminus AAA_13 PF13166.6 EMD59316.1 - 5.2 5.6 16.7 9.5 4.7 16.7 1.3 1 0 0 1 1 1 0 AAA domain DUF3450 PF11932.8 EMD59316.1 - 5.6 6.2 30.4 5.8 6.1 14.8 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) LPP PF04728.13 EMD59316.1 - 5.8 7.4 11.5 6.5 7.2 0.2 3.4 3 0 0 3 3 2 0 Lipoprotein leucine-zipper Nsp1_C PF05064.13 EMD59316.1 - 7 6.5 15.9 0.28 11.0 4.2 2.8 1 1 1 2 2 2 0 Nsp1-like C-terminal region SKA1 PF07160.12 EMD59316.1 - 7.2 6.4 22.2 6.5 6.5 9.6 2.7 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 1 FUSC PF04632.12 EMD59316.1 - 7.8 4.9 9.5 12 4.3 9.5 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Laminin_II PF06009.12 EMD59316.1 - 9.1 6.3 19.2 6.5 6.8 7.8 2.4 1 1 1 2 2 2 0 Laminin Domain II Prefoldin_2 PF01920.20 EMD59316.1 - 9.4 6.2 24.5 3.5 7.6 1.2 4.1 2 2 1 3 3 3 0 Prefoldin subunit MMU163 PF17119.5 EMD59317.1 - 8.4e-90 300.3 5.6 1.4e-64 217.7 0.2 2.1 1 1 1 2 2 2 2 Mitochondrial protein up-regulated during meiosis Epimerase PF01370.21 EMD59318.1 - 3.2e-21 75.9 0.1 3.8e-20 72.4 0.1 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EMD59318.1 - 6.4e-11 42.2 0.8 1e-09 38.2 0.4 2.5 1 1 0 2 2 2 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 EMD59318.1 - 6.6e-08 31.9 0.1 2.9e-07 29.8 0.1 1.8 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 EMD59318.1 - 1.9e-07 30.5 0.0 3.2e-07 29.8 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 EMD59318.1 - 7.6e-07 28.6 0.1 0.00082 18.6 0.3 2.7 2 1 0 2 2 2 2 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 EMD59318.1 - 3.8e-06 26.3 0.0 1.6e-05 24.2 0.0 1.8 2 0 0 2 2 2 1 Male sterility protein NAD_binding_10 PF13460.6 EMD59318.1 - 2.1e-05 24.5 0.0 4.2e-05 23.5 0.0 1.4 1 1 0 1 1 1 1 NAD(P)H-binding Vps51 PF08700.11 EMD59319.1 - 3.3e-13 49.5 0.0 1.8e-12 47.1 0.0 2.4 1 0 0 1 1 1 1 Vps51/Vps67 Chorismate_bind PF00425.18 EMD59320.1 - 4.3e-65 219.8 0.4 2.3e-37 129.0 0.1 2.3 2 0 0 2 2 2 2 chorismate binding enzyme GATase PF00117.28 EMD59320.1 - 5.6e-29 101.3 0.0 1.6e-28 99.8 0.0 1.8 1 1 0 1 1 1 1 Glutamine amidotransferase class-I Anth_synt_I_N PF04715.13 EMD59320.1 - 1.8e-15 57.4 0.0 7.1e-15 55.5 0.0 2.1 1 0 0 1 1 1 1 Anthranilate synthase component I, N terminal region Peptidase_C26 PF07722.13 EMD59320.1 - 4.1e-05 23.4 2.0 0.00052 19.8 2.0 2.2 1 1 0 1 1 1 1 Peptidase C26 FAD_binding_6 PF00970.24 EMD59321.1 - 2.2e-08 34.4 0.0 8.1e-08 32.5 0.0 2.1 2 1 0 2 2 2 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 EMD59321.1 - 3.4e-08 34.1 0.0 8.7e-05 23.1 0.0 2.3 2 0 0 2 2 2 2 Oxidoreductase NAD-binding domain MFS_1 PF07690.16 EMD59322.1 - 7.2e-39 133.7 43.6 1.4e-37 129.4 43.8 2.4 2 1 0 2 2 2 2 Major Facilitator Superfamily HLH PF00010.26 EMD59323.1 - 1.3e-05 25.1 0.0 2.5e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Cep57_CLD_2 PF14197.6 EMD59323.1 - 0.82 9.8 6.1 1.5 9.0 6.1 1.4 1 0 0 1 1 1 0 Centrosome localisation domain of PPC89 TFIIA PF03153.13 EMD59323.1 - 1.9 8.4 13.2 0.51 10.3 9.8 1.5 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit MFS_1 PF07690.16 EMD59324.1 - 1.4e-07 30.8 24.4 5.2e-07 28.9 20.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily cwf21 PF08312.12 EMD59325.1 - 6.7e-16 58.2 11.3 6.7e-16 58.2 11.3 2.6 2 1 0 2 2 2 1 cwf21 domain Trans_reg_C PF00486.28 EMD59325.1 - 0.09 12.9 3.7 0.49 10.5 0.2 2.9 2 1 1 3 3 3 0 Transcriptional regulatory protein, C terminal D123 PF07065.14 EMD59326.1 - 1.6e-118 395.4 1.8 2e-118 395.0 1.8 1.1 1 0 0 1 1 1 1 D123 Sigma70_ner PF04546.13 EMD59326.1 - 0.014 15.3 2.3 0.098 12.5 0.3 2.2 2 0 0 2 2 2 0 Sigma-70, non-essential region FAM176 PF14851.6 EMD59326.1 - 4.5 6.9 6.5 0.59 9.8 1.1 2.0 2 0 0 2 2 2 0 FAM176 family Zn_clus PF00172.18 EMD59328.1 - 4.6e-07 29.8 10.2 9.4e-07 28.9 10.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EMD59328.1 - 1.4e-05 24.1 0.3 1.8e-05 23.8 0.3 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain AA_permease PF00324.21 EMD59329.1 - 8.9e-126 420.3 45.1 1e-125 420.1 45.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EMD59329.1 - 4.4e-33 114.7 50.5 5.4e-33 114.5 50.5 1.1 1 0 0 1 1 1 1 Amino acid permease GCR PF02155.15 EMD59329.1 - 0.059 12.4 0.3 0.086 11.9 0.3 1.1 1 0 0 1 1 1 0 Glucocorticoid receptor Egh16-like PF11327.8 EMD59330.1 - 1.6e-67 227.5 14.3 2e-67 227.2 14.3 1.1 1 0 0 1 1 1 1 Egh16-like virulence factor HET PF06985.11 EMD59332.1 - 5.2e-09 36.6 0.0 6.9e-09 36.2 0.0 1.2 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Fungal_trans PF04082.18 EMD59333.1 - 1.5e-27 96.3 0.0 3.2e-27 95.2 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD59333.1 - 2e-09 37.4 10.9 3.2e-09 36.8 10.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TFIIA PF03153.13 EMD59333.1 - 2 8.3 16.4 4.4 7.2 16.4 1.5 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit GCN5L1 PF06320.13 EMD59333.1 - 2.3 8.4 4.4 0.81 9.8 0.0 2.4 2 0 0 2 2 2 0 GCN5-like protein 1 (GCN5L1) DUF3328 PF11807.8 EMD59335.1 - 3.9e-48 164.1 1.8 4.8e-48 163.8 1.8 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) GPAT_N PF14829.6 EMD59335.1 - 0.17 11.9 0.2 6.8 6.8 0.0 2.7 3 0 0 3 3 3 0 Glycerol-3-phosphate acyltransferase N-terminal Sen15 PF09631.10 EMD59336.1 - 1.1e-23 83.4 0.0 1.8e-23 82.7 0.0 1.4 1 0 0 1 1 1 1 Sen15 protein DUF2985 PF11204.8 EMD59338.1 - 2.3e-38 130.2 3.8 2.3e-38 130.2 3.8 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF2985) DUF456 PF04306.13 EMD59339.1 - 0.045 14.0 0.0 0.063 13.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF456) Zip PF02535.22 EMD59339.1 - 0.096 11.9 7.4 0.15 11.3 7.4 1.5 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 EMD59339.1 - 0.52 9.0 1.0 0.68 8.6 1.0 1.1 1 0 0 1 1 1 0 Presenilin Bacteriocin_IIc PF10439.9 EMD59339.1 - 1 9.5 5.3 1.8 8.7 5.3 1.2 1 0 0 1 1 1 0 Bacteriocin class II with double-glycine leader peptide RR_TM4-6 PF06459.12 EMD59339.1 - 1.6 8.5 4.7 2.5 7.9 4.7 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 ERG4_ERG24 PF01222.17 EMD59340.1 - 1.1e-162 541.7 6.6 1.3e-162 541.5 6.6 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.12 EMD59340.1 - 0.00028 20.5 0.2 0.00075 19.1 0.2 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) Man-6-P_recep PF02157.15 EMD59341.1 - 3.7e-16 59.0 0.0 6.3e-16 58.2 0.0 1.3 1 0 0 1 1 1 1 Mannose-6-phosphate receptor ATG27 PF09451.10 EMD59341.1 - 7.2e-09 35.9 0.0 2.2e-08 34.3 0.0 1.7 2 0 0 2 2 2 1 Autophagy-related protein 27 CIMR PF00878.18 EMD59341.1 - 1.5e-05 25.1 0.0 0.0018 18.4 0.0 2.4 2 1 0 2 2 2 2 Cation-independent mannose-6-phosphate receptor repeat Dynamin_N PF00350.23 EMD59342.1 - 1.2e-17 64.4 3.3 2.6e-17 63.4 0.0 3.2 2 1 1 3 3 2 1 Dynamin family MMR_HSR1 PF01926.23 EMD59342.1 - 1.7e-05 24.9 1.5 0.00016 21.7 0.3 3.0 2 1 0 2 2 1 1 50S ribosome-binding GTPase ABC_tran PF00005.27 EMD59342.1 - 0.00032 21.2 0.0 0.00032 21.2 0.0 2.8 3 1 0 3 3 1 1 ABC transporter RsgA_GTPase PF03193.16 EMD59342.1 - 0.0011 18.9 0.7 0.0058 16.6 0.0 2.5 3 0 0 3 3 2 1 RsgA GTPase DUF4201 PF13870.6 EMD59342.1 - 0.0012 18.6 1.7 0.0012 18.6 1.7 3.6 4 0 0 4 4 3 1 Domain of unknown function (DUF4201) IIGP PF05049.13 EMD59342.1 - 0.0032 16.6 0.2 0.012 14.7 0.0 2.0 2 0 0 2 2 2 1 Interferon-inducible GTPase (IIGP) AAA_16 PF13191.6 EMD59342.1 - 0.028 14.8 0.4 1.1 9.6 0.0 3.4 4 0 0 4 4 3 0 AAA ATPase domain T2SSE PF00437.20 EMD59342.1 - 0.029 13.4 0.0 0.066 12.3 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein AIG1 PF04548.16 EMD59342.1 - 0.046 13.0 0.1 0.14 11.5 0.1 1.8 1 0 0 1 1 1 0 AIG1 family Zeta_toxin PF06414.12 EMD59342.1 - 0.058 12.7 1.3 0.18 11.1 0.0 2.4 3 0 0 3 3 3 0 Zeta toxin AAA_22 PF13401.6 EMD59342.1 - 0.062 13.6 0.1 0.43 10.8 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 EMD59342.1 - 0.078 12.7 0.0 0.17 11.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain KASH_CCD PF14662.6 EMD59342.1 - 0.087 12.7 16.1 0.14 12.0 1.3 3.3 3 0 0 3 3 3 0 Coiled-coil region of CCDC155 or KASH ZapB PF06005.12 EMD59342.1 - 0.16 12.4 12.6 0.092 13.2 2.8 3.5 2 0 0 2 2 2 0 Cell division protein ZapB MeaB PF03308.16 EMD59342.1 - 0.19 10.7 0.7 0.36 9.8 0.1 1.7 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB YabA PF06156.13 EMD59342.1 - 0.21 12.2 12.7 1.9 9.2 1.5 4.4 4 0 0 4 4 4 0 Initiation control protein YabA DUF4795 PF16043.5 EMD59342.1 - 0.58 9.7 14.3 1.1 8.8 1.4 4.3 5 0 0 5 5 4 0 Domain of unknown function (DUF4795) DUF3450 PF11932.8 EMD59342.1 - 1.8 7.8 12.8 1.4 8.2 3.9 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) PIN_4 PF13638.6 EMD59342.1 - 1.9 8.8 7.7 0.53 10.6 0.5 3.4 4 0 0 4 4 4 0 PIN domain ABC_tran_CTD PF16326.5 EMD59342.1 - 2.7 8.3 15.5 0.5 10.7 0.8 4.6 4 0 0 4 4 4 0 ABC transporter C-terminal domain DUF5082 PF16888.5 EMD59342.1 - 2.7 8.3 12.1 8 6.8 1.4 3.5 3 0 0 3 3 2 0 Domain of unknown function (DUF5082) DUF724 PF05266.14 EMD59342.1 - 2.9 7.7 13.7 1.2 9.0 0.6 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF724) BRE1 PF08647.11 EMD59342.1 - 5.3 7.2 12.5 6.6 6.9 2.6 4.0 3 0 0 3 3 3 0 BRE1 E3 ubiquitin ligase E2F_CC-MB PF16421.5 EMD59342.1 - 5.4 7.5 8.4 1.7 9.1 1.5 3.3 3 0 0 3 3 3 0 E2F transcription factor CC-MB domain ATG16 PF08614.11 EMD59342.1 - 6.1 7.0 17.0 0.19 12.0 1.8 3.2 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Peptidase_M66 PF10462.9 EMD59343.1 - 0.023 13.7 0.0 0.037 13.0 0.0 1.2 1 0 0 1 1 1 0 Peptidase M66 MPTase-PolyVal PF18818.1 EMD59343.1 - 0.21 11.7 0.4 0.42 10.7 0.0 1.6 2 0 0 2 2 2 0 Metallopeptidase superfamily domain zf-RING_UBOX PF13445.6 EMD59344.1 - 1.3e-09 37.9 3.1 2.7e-09 36.9 3.1 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 EMD59344.1 - 1.4e-08 34.9 3.2 2.6e-08 34.1 3.2 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EMD59344.1 - 6e-06 26.0 2.2 1.2e-05 25.0 2.2 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EMD59344.1 - 1e-05 25.7 2.7 1.8e-05 24.9 2.7 1.3 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 EMD59344.1 - 1.3e-05 24.9 2.9 2.5e-05 24.1 2.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EMD59344.1 - 0.001 18.8 2.1 0.001 18.8 2.1 2.6 3 0 0 3 3 3 1 RING-like zinc finger zf-ANAPC11 PF12861.7 EMD59344.1 - 0.0017 18.4 1.7 0.0026 17.8 1.7 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.6 EMD59344.1 - 0.0018 18.2 2.6 0.0034 17.3 2.6 1.5 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EMD59344.1 - 0.0027 17.5 6.0 0.16 11.9 5.7 2.4 1 1 1 2 2 2 2 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 EMD59344.1 - 0.0047 16.8 1.8 0.011 15.6 1.8 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_5 PF17121.5 EMD59344.1 - 0.0054 16.6 1.8 0.01 15.7 1.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EMD59344.1 - 0.012 15.8 1.3 0.028 14.6 1.3 1.7 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING Zn_ribbon_17 PF17120.5 EMD59344.1 - 0.014 15.0 1.4 0.028 14.0 1.4 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_6 PF14835.6 EMD59344.1 - 0.046 13.6 1.2 0.1 12.5 1.1 1.6 1 1 0 1 1 1 0 zf-RING of BARD1-type protein RINGv PF12906.7 EMD59344.1 - 0.063 13.4 1.0 0.15 12.2 1.0 1.7 1 1 0 1 1 1 0 RING-variant domain zf-Nse PF11789.8 EMD59344.1 - 0.1 12.4 0.4 0.17 11.7 0.4 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Pkinase PF00069.25 EMD59349.1 - 0.025 14.0 0.0 0.025 14.0 0.0 1.1 1 0 0 1 1 1 0 Protein kinase domain Fungal_trans_2 PF11951.8 EMD59350.1 - 2.6e-11 43.0 0.6 3.3e-10 39.3 0.2 2.0 2 0 0 2 2 2 2 Fungal specific transcription factor domain PhyH PF05721.13 EMD59351.1 - 7.4e-11 42.7 0.0 1.4e-10 41.8 0.0 1.5 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) WD40 PF00400.32 EMD59352.1 - 1.1e-13 51.3 10.4 0.057 14.3 0.1 5.9 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD59352.1 - 9e-05 22.7 0.2 0.089 13.1 0.1 4.1 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain TF_Zn_Ribbon PF08271.12 EMD59352.1 - 0.0046 16.5 0.4 0.0046 16.5 0.4 2.3 2 0 0 2 2 2 1 TFIIB zinc-binding Nucleoporin_N PF08801.11 EMD59352.1 - 0.044 12.5 0.0 0.17 10.6 0.0 1.9 2 1 1 3 3 3 0 Nup133 N terminal like ATPase-cat_bd PF12156.8 EMD59352.1 - 1.6 9.5 4.7 5.5 7.8 4.7 2.0 1 0 0 1 1 1 0 Putative metal-binding domain of cation transport ATPase AA_permease_2 PF13520.6 EMD59353.1 - 1.7e-66 224.8 50.0 2.1e-66 224.5 50.0 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EMD59353.1 - 1.5e-34 119.4 44.2 2.1e-34 119.0 44.2 1.0 1 0 0 1 1 1 1 Amino acid permease Sec16_C PF12931.7 EMD59354.1 - 1.7e-114 382.6 0.0 2.2e-114 382.2 0.0 1.2 1 0 0 1 1 1 1 Sec23-binding domain of Sec16 Sec16 PF12932.7 EMD59354.1 - 2.8e-35 121.5 0.3 2.2e-34 118.6 0.0 2.6 2 0 0 2 2 2 1 Vesicle coat trafficking protein Sec16 mid-region PhoLip_ATPase_C PF16212.5 EMD59355.1 - 8.7e-57 192.7 8.4 8.7e-57 192.7 8.4 2.0 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EMD59355.1 - 7.3e-17 60.8 0.1 1.5e-16 59.8 0.1 1.5 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 EMD59355.1 - 2.8e-13 50.7 1.0 1.5e-09 38.4 1.0 3.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 EMD59355.1 - 4.9e-10 39.2 0.1 5.2e-08 32.6 0.1 2.6 1 1 0 1 1 1 1 E1-E2 ATPase Cation_ATPase PF13246.6 EMD59355.1 - 3.8e-07 30.1 0.0 6.6e-06 26.1 0.0 2.4 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EMD59355.1 - 0.0036 17.1 0.0 0.0062 16.3 0.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF4579 PF15158.6 EMD59355.1 - 0.055 13.2 0.1 0.14 12.0 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4579) DUF3431 PF11913.8 EMD59357.1 - 1.6e-11 44.4 0.0 3.8e-11 43.2 0.0 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF3431) Methyltransf_11 PF08241.12 EMD59358.1 - 4.3e-10 40.1 0.0 8.2e-10 39.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMD59358.1 - 2.1e-09 37.9 0.0 4.2e-09 37.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMD59358.1 - 7.7e-06 26.6 0.3 0.00013 22.6 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EMD59358.1 - 2.2e-05 24.3 0.0 6.7e-05 22.8 0.0 1.9 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMD59358.1 - 0.0003 20.6 0.0 0.00065 19.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain CPBP PF02517.16 EMD59359.1 - 1.2e-15 57.6 8.9 1.2e-15 57.6 8.9 2.8 3 1 1 4 4 4 1 CPBP intramembrane metalloprotease eIF-6 PF01912.18 EMD59361.1 - 2.1e-80 268.8 1.6 2.9e-80 268.3 1.6 1.2 1 0 0 1 1 1 1 eIF-6 family Es2 PF09751.9 EMD59362.1 - 1.7e-116 390.5 9.7 2.1e-116 390.2 9.7 1.1 1 0 0 1 1 1 1 Nuclear protein Es2 Sds3 PF08598.11 EMD59363.1 - 5.6e-06 26.5 3.2 5.6e-06 26.5 3.2 2.5 2 0 0 2 2 2 1 Sds3-like XPC-binding PF09280.11 EMD59365.1 - 1e-24 86.0 15.7 1.8e-24 85.2 15.7 1.4 1 0 0 1 1 1 1 XPC-binding domain ubiquitin PF00240.23 EMD59365.1 - 1.4e-21 76.0 0.1 2.1e-21 75.4 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin family UBA PF00627.31 EMD59365.1 - 2.1e-21 75.4 7.0 6.7e-13 48.3 0.5 2.5 2 0 0 2 2 2 2 UBA/TS-N domain Rad60-SLD PF11976.8 EMD59365.1 - 7.4e-07 28.9 0.1 1.2e-06 28.2 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF4719 PF15843.5 EMD59365.1 - 0.001 19.3 2.7 0.0019 18.4 2.7 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4719) Rad60-SLD_2 PF13881.6 EMD59365.1 - 0.011 15.9 0.0 0.022 14.9 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like UBA_3 PF09288.10 EMD59365.1 - 0.015 15.1 0.0 1.1 9.1 0.0 2.4 2 0 0 2 2 2 0 Fungal ubiquitin-associated domain MCM_N PF14551.6 EMD59365.1 - 0.068 13.8 0.1 0.15 12.7 0.1 1.6 1 0 0 1 1 1 0 MCM N-terminal domain DUF2407 PF10302.9 EMD59365.1 - 0.15 12.6 0.0 0.3 11.7 0.0 1.5 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain Kri1_C PF12936.7 EMD59366.1 - 9.2e-30 102.7 1.0 9.2e-30 102.7 1.0 4.3 6 0 0 6 6 6 1 KRI1-like family C-terminal Kri1 PF05178.12 EMD59366.1 - 2e-28 98.9 16.7 2e-28 98.9 16.7 5.9 5 2 1 6 6 6 1 KRI1-like family VASt PF16016.5 EMD59367.1 - 4e-28 98.7 0.0 7.9e-28 97.8 0.0 1.5 1 0 0 1 1 1 1 VAD1 Analog of StAR-related lipid transfer domain BAR_3 PF16746.5 EMD59367.1 - 8.6e-17 61.6 0.1 1.7e-16 60.6 0.1 1.5 1 0 0 1 1 1 1 BAR domain of APPL family PH PF00169.29 EMD59367.1 - 1.4e-10 41.7 0.1 1.3e-09 38.5 0.1 2.5 2 0 0 2 2 2 1 PH domain BAR PF03114.18 EMD59367.1 - 0.00071 19.3 0.2 0.0018 17.9 0.2 1.7 1 0 0 1 1 1 1 BAR domain GRAM PF02893.20 EMD59367.1 - 0.00098 19.0 0.0 0.0025 17.7 0.0 1.7 1 0 0 1 1 1 1 GRAM domain DUF2353 PF09789.9 EMD59367.1 - 0.071 12.5 0.1 0.13 11.6 0.1 1.3 1 0 0 1 1 1 0 Uncharacterized coiled-coil protein (DUF2353) PH_13 PF16652.5 EMD59367.1 - 0.075 12.8 0.1 0.79 9.5 0.0 2.4 2 0 0 2 2 2 0 Pleckstrin homology domain ubiquitin PF00240.23 EMD59368.1 - 3.2e-12 46.0 0.0 6e-12 45.1 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family TBK1_ULD PF18396.1 EMD59368.1 - 0.0024 17.8 0.1 0.0047 16.8 0.1 1.4 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD PF11976.8 EMD59368.1 - 0.0052 16.6 0.1 0.014 15.2 0.0 1.7 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EMD59368.1 - 0.051 14.0 0.0 0.2 12.1 0.0 2.0 2 0 0 2 2 2 0 Ubiquitin-like domain Ribosomal_S14 PF00253.21 EMD59369.1 - 5.3e-12 45.3 0.6 6e-12 45.1 0.6 1.1 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e CAP PF00188.26 EMD59371.1 - 2.2e-05 25.3 0.0 4.8e-05 24.2 0.0 1.5 1 1 0 1 1 1 1 Cysteine-rich secretory protein family Thermopsin PF05317.11 EMD59373.1 - 0.032 13.7 0.1 0.05 13.1 0.1 1.4 1 1 0 1 1 1 0 Thermopsin Bys1 PF04681.12 EMD59373.1 - 0.053 13.4 1.1 0.056 13.4 0.3 1.4 2 0 0 2 2 2 0 Blastomyces yeast-phase-specific protein Big_2 PF02368.18 EMD59373.1 - 0.11 12.4 0.1 0.22 11.4 0.1 1.4 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 2) Haem_degrading PF03928.14 EMD59374.1 - 6.6e-27 93.9 1.1 1.1e-26 93.3 1.1 1.3 1 0 0 1 1 1 1 Haem-degrading CHASE8 PF17152.4 EMD59374.1 - 0.019 15.2 0.1 0.053 13.8 0.1 1.7 2 0 0 2 2 2 0 Periplasmic sensor domain DUF1056 PF06341.11 EMD59375.1 - 3.5 8.0 5.2 1 9.7 0.9 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1056) adh_short PF00106.25 EMD59376.1 - 3.7e-26 91.8 0.0 5e-22 78.3 0.0 2.2 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EMD59376.1 - 1e-15 57.9 0.0 1.4e-13 51.0 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD59376.1 - 8.9e-07 29.0 0.0 1.4e-06 28.3 0.0 1.3 1 0 0 1 1 1 1 KR domain Shikimate_DH PF01488.20 EMD59376.1 - 0.011 15.8 0.2 0.027 14.5 0.1 1.6 1 1 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.17 EMD59376.1 - 0.018 15.6 0.3 0.046 14.3 0.3 1.7 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Phage_capsid PF05065.13 EMD59376.1 - 0.087 12.1 0.1 0.13 11.5 0.1 1.2 1 0 0 1 1 1 0 Phage capsid family Polysacc_synt_2 PF02719.15 EMD59376.1 - 0.093 11.8 0.0 0.15 11.2 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein 2-Hacid_dh_C PF02826.19 EMD59376.1 - 0.11 11.8 0.1 0.18 11.2 0.1 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain SIR2 PF02146.17 EMD59377.1 - 7.4e-37 127.0 0.0 1.1e-36 126.4 0.0 1.2 1 0 0 1 1 1 1 Sir2 family MFS_1 PF07690.16 EMD59378.1 - 4.4e-41 141.0 22.9 4.4e-41 141.0 22.9 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EMD59378.1 - 2.1e-10 40.1 6.6 2.1e-10 40.1 6.6 3.3 2 2 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 EMD59378.1 - 0.00017 20.1 1.3 0.00025 19.6 1.3 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) GPR_Gpa2_C PF11970.8 EMD59378.1 - 7.6 6.7 7.8 0.66 10.1 0.1 2.8 3 0 0 3 3 3 0 G protein-coupled glucose receptor regulating Gpa2 C-term Gly_kinase PF02595.15 EMD59379.1 - 1.4e-60 205.3 0.6 1.7e-60 205.0 0.6 1.0 1 0 0 1 1 1 1 Glycerate kinase family FAD_binding_3 PF01494.19 EMD59380.1 - 7.7e-25 87.9 0.0 7.7e-24 84.6 0.0 2.0 1 1 0 1 1 1 1 FAD binding domain Trp_halogenase PF04820.14 EMD59380.1 - 7.9e-05 21.7 0.2 0.0016 17.4 0.1 2.1 2 0 0 2 2 2 1 Tryptophan halogenase NAD_binding_8 PF13450.6 EMD59380.1 - 0.00067 19.8 0.2 0.002 18.4 0.2 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EMD59380.1 - 0.018 14.7 0.8 0.061 12.9 0.3 2.0 2 1 1 3 3 3 0 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EMD59380.1 - 0.04 13.0 0.6 0.082 12.0 0.2 1.7 2 0 0 2 2 2 0 FAD binding domain zf-CCCH PF00642.24 EMD59381.1 - 4.2e-07 29.7 14.5 0.0022 17.9 1.9 2.6 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EMD59381.1 - 0.0036 17.3 18.7 0.0076 16.3 1.5 2.5 2 0 0 2 2 2 2 Zinc finger domain DUF349 PF03993.12 EMD59381.1 - 0.12 12.7 5.2 0.18 12.1 0.5 3.0 3 1 0 3 3 3 0 Domain of Unknown Function (DUF349) Enkurin PF13864.6 EMD59381.1 - 0.91 10.0 4.8 2.1 8.8 0.7 2.3 2 0 0 2 2 2 0 Calmodulin-binding GST_C_3 PF14497.6 EMD59382.1 - 3.5e-28 97.7 0.8 5.5e-28 97.1 0.8 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EMD59382.1 - 4.4e-06 26.8 0.1 8e-06 26.0 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EMD59382.1 - 0.0001 22.2 0.0 0.00018 21.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Ribosomal_S7e PF01251.18 EMD59383.1 - 2.9e-79 265.1 0.0 3.4e-79 264.9 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S7e MARVEL PF01284.23 EMD59384.1 - 2.9e-18 66.3 0.2 3.8e-18 65.9 0.2 1.2 1 0 0 1 1 1 1 Membrane-associating domain Amastin PF07344.11 EMD59384.1 - 0.00052 19.9 0.0 0.012 15.5 0.3 2.3 2 1 0 2 2 2 1 Amastin surface glycoprotein TNFR_16_TM PF18422.1 EMD59384.1 - 0.026 14.5 0.2 0.1 12.6 0.2 2.0 1 0 0 1 1 1 0 Tumor necrosis factor receptor member 16 trans-membrane domain 7TM_GPCR_Sru PF10322.9 EMD59384.1 - 0.34 10.2 0.0 0.34 10.2 0.0 2.0 2 1 1 3 3 3 0 Serpentine type 7TM GPCR chemoreceptor Sru Use1 PF09753.9 EMD59385.1 - 0.014 15.1 0.1 0.038 13.7 0.1 1.7 1 1 0 1 1 1 0 Membrane fusion protein Use1 ADK PF00406.22 EMD59386.1 - 3.7e-58 195.9 0.0 5e-58 195.5 0.0 1.2 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 EMD59386.1 - 5.7e-22 78.6 0.3 1.5e-21 77.2 0.1 1.7 2 0 0 2 2 2 1 AAA domain ADK_lid PF05191.14 EMD59386.1 - 8e-17 60.9 0.0 2e-16 59.7 0.0 1.7 2 0 0 2 2 2 1 Adenylate kinase, active site lid AAA_18 PF13238.6 EMD59386.1 - 8.1e-05 23.2 0.0 0.00016 22.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EMD59386.1 - 0.00072 19.7 0.0 0.0015 18.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain Dynactin_p22 PF07426.11 EMD59386.1 - 0.055 13.3 0.1 0.11 12.3 0.1 1.5 1 0 0 1 1 1 0 Dynactin subunit p22 Cytidylate_kin PF02224.18 EMD59386.1 - 0.13 12.0 0.0 0.19 11.4 0.0 1.3 1 0 0 1 1 1 0 Cytidylate kinase RNA12 PF10443.9 EMD59387.1 - 1.2e-169 564.7 0.1 3e-169 563.4 0.0 1.7 2 0 0 2 2 2 1 RNA12 protein RRM_1 PF00076.22 EMD59387.1 - 6e-05 22.8 0.0 0.00025 20.8 0.0 2.0 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ATPase_2 PF01637.18 EMD59387.1 - 0.00042 20.3 0.0 0.0047 16.9 0.0 2.5 3 0 0 3 3 3 1 ATPase domain predominantly from Archaea DUF2487 PF10673.9 EMD59387.1 - 0.0079 16.2 0.0 0.021 14.9 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2487) NUDIX PF00293.28 EMD59388.1 - 2.6e-09 37.2 0.0 4.5e-09 36.5 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain AICARFT_IMPCHas PF01808.18 EMD59389.1 - 3.1e-91 305.9 0.0 4.2e-91 305.5 0.0 1.2 1 0 0 1 1 1 1 AICARFT/IMPCHase bienzyme MGS PF02142.22 EMD59389.1 - 8.9e-24 83.5 0.0 1.6e-23 82.7 0.0 1.5 1 0 0 1 1 1 1 MGS-like domain CHZ PF09649.10 EMD59390.1 - 1.3e-15 56.6 1.5 1.3e-15 56.6 1.5 1.7 2 0 0 2 2 2 1 Histone chaperone domain CHZ Spc42p PF11544.8 EMD59390.1 - 0.11 12.5 0.0 0.22 11.5 0.0 1.6 1 0 0 1 1 1 0 Spindle pole body component Spc42p GATase_2 PF00310.21 EMD59391.1 - 2.8e-180 599.5 0.0 4.1e-180 599.0 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferases class-II Glu_synthase PF01645.17 EMD59391.1 - 7.2e-155 515.6 0.0 3.2e-154 513.5 0.0 1.9 2 0 0 2 2 2 1 Conserved region in glutamate synthase Glu_syn_central PF04898.14 EMD59391.1 - 8.2e-113 376.5 0.0 4.8e-111 370.7 0.0 2.3 2 0 0 2 2 2 1 Glutamate synthase central domain GXGXG PF01493.19 EMD59391.1 - 2.1e-87 291.7 1.4 3.4e-87 291.0 1.4 1.4 1 0 0 1 1 1 1 GXGXG motif Pyr_redox_2 PF07992.14 EMD59391.1 - 5.1e-24 85.0 0.0 2.1e-23 83.0 0.0 2.0 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Fer4_20 PF14691.6 EMD59391.1 - 1.7e-20 72.9 0.1 3.4e-20 71.9 0.1 1.5 1 0 0 1 1 1 1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster NAD_binding_8 PF13450.6 EMD59391.1 - 3.4e-09 36.8 0.0 1.2e-08 35.1 0.0 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 EMD59391.1 - 1.1e-07 32.3 0.3 0.00012 22.6 0.1 2.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EMD59391.1 - 1.8e-07 30.7 0.1 0.001 18.4 0.0 3.4 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EMD59391.1 - 4.9e-07 29.6 1.0 0.0013 18.4 0.4 2.5 2 0 0 2 2 2 2 FAD dependent oxidoreductase Amino_oxidase PF01593.24 EMD59391.1 - 2e-06 27.4 0.0 3.8e-06 26.5 0.0 1.5 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase HI0933_like PF03486.14 EMD59391.1 - 1.5e-05 23.9 0.2 1.5e-05 23.9 0.2 1.5 2 0 0 2 2 2 1 HI0933-like protein FAD_binding_2 PF00890.24 EMD59391.1 - 5e-05 22.6 0.4 0.00022 20.4 0.1 2.1 2 0 0 2 2 2 1 FAD binding domain FAD_oxidored PF12831.7 EMD59391.1 - 0.00032 20.2 0.3 0.00076 18.9 0.3 1.6 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_7 PF13241.6 EMD59391.1 - 0.00042 20.7 0.1 1.7 9.1 0.1 2.9 2 0 0 2 2 2 2 Putative NAD(P)-binding FMO-like PF00743.19 EMD59391.1 - 0.00076 18.0 0.4 0.37 9.1 0.0 3.0 2 1 1 3 3 3 2 Flavin-binding monooxygenase-like FAD_binding_3 PF01494.19 EMD59391.1 - 0.0015 17.8 0.0 0.0033 16.7 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain Lycopene_cycl PF05834.12 EMD59391.1 - 0.002 17.2 0.3 0.19 10.7 0.2 2.4 2 0 0 2 2 2 1 Lycopene cyclase protein Thi4 PF01946.17 EMD59391.1 - 0.0036 16.6 0.1 0.0097 15.2 0.1 1.7 1 0 0 1 1 1 1 Thi4 family AlaDh_PNT_C PF01262.21 EMD59391.1 - 0.015 14.6 0.3 2.2 7.5 0.0 2.3 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain AdoHcyase_NAD PF00670.21 EMD59391.1 - 0.02 15.0 0.4 2 8.5 0.1 2.6 2 0 0 2 2 2 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain FMN_dh PF01070.18 EMD59391.1 - 0.041 12.9 0.3 0.14 11.2 0.6 1.7 2 0 0 2 2 2 0 FMN-dependent dehydrogenase NAD_Gly3P_dh_N PF01210.23 EMD59391.1 - 0.06 13.3 0.0 0.13 12.2 0.0 1.6 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_binding_9 PF13454.6 EMD59391.1 - 0.072 13.1 0.0 0.29 11.1 0.0 2.1 1 0 0 1 1 1 0 FAD-NAD(P)-binding 2-Hacid_dh_C PF02826.19 EMD59391.1 - 0.13 11.6 0.1 0.57 9.5 0.0 2.0 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 EMD59391.1 - 0.14 12.3 0.1 24 5.0 0.0 2.8 3 0 0 3 3 2 0 Shikimate / quinate 5-dehydrogenase Caskin-tail PF16632.5 EMD59391.1 - 0.14 12.6 0.0 0.38 11.2 0.0 1.7 1 0 0 1 1 1 0 C-terminal region of Caskin MADF_DNA_bdg PF10545.9 EMD59391.1 - 0.17 12.2 0.7 0.42 11.0 0.7 1.6 1 0 0 1 1 1 0 Alcohol dehydrogenase transcription factor Myb/SANT-like GIDA PF01134.22 EMD59391.1 - 0.56 9.2 2.6 0.49 9.4 0.1 2.0 2 0 0 2 2 2 0 Glucose inhibited division protein A Ank_4 PF13637.6 EMD59392.1 - 5.2e-25 87.5 3.0 2.2e-09 37.7 0.1 3.0 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 EMD59392.1 - 4.1e-15 56.1 0.2 2.9e-11 43.8 0.1 2.1 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 EMD59392.1 - 1e-13 51.0 1.8 0.0033 17.8 0.0 4.1 4 0 0 4 4 4 3 Ankyrin repeat Ank_3 PF13606.6 EMD59392.1 - 3.9e-09 36.0 0.8 0.086 13.4 0.0 3.9 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 EMD59392.1 - 4.7e-07 30.0 1.5 0.0036 17.6 0.1 3.0 1 1 2 3 3 3 2 Ankyrin repeats (many copies) FLgD_tudor PF13861.6 EMD59392.1 - 0.0023 18.2 0.3 3.3 8.0 0.1 3.0 2 1 0 2 2 2 2 FlgD Tudor-like domain DUF2274 PF10038.9 EMD59393.1 - 0.077 13.5 0.6 1.1 9.8 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2274) AAA_22 PF13401.6 EMD59394.1 - 1.9e-05 25.0 0.0 5.2e-05 23.5 0.0 1.8 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 EMD59394.1 - 0.00028 20.8 0.0 0.00075 19.4 0.0 1.7 2 0 0 2 2 2 1 NACHT domain DUF692 PF05114.13 EMD59394.1 - 0.0071 15.6 0.3 0.012 14.9 0.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF692) VWA_3 PF13768.6 EMD59394.1 - 0.052 13.5 0.3 0.15 12.0 0.3 1.7 1 0 0 1 1 1 0 von Willebrand factor type A domain AAA PF00004.29 EMD59394.1 - 0.12 12.8 0.1 1 9.8 0.1 2.4 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DDE_1 PF03184.19 EMD59396.1 - 0.16 11.7 0.0 0.22 11.2 0.0 1.2 1 0 0 1 1 1 0 DDE superfamily endonuclease Aldedh PF00171.22 EMD59397.1 - 1.2e-154 515.3 0.4 1.5e-154 515.0 0.4 1.1 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Fungal_trans PF04082.18 EMD59397.1 - 2.8e-13 49.5 0.5 1.6e-12 47.0 0.0 2.2 1 1 1 2 2 2 1 Fungal specific transcription factor domain LuxC PF05893.14 EMD59397.1 - 0.00085 18.5 0.0 0.0018 17.4 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA reductase (LuxC) DUF1487 PF07368.11 EMD59397.1 - 0.0077 15.7 0.0 0.26 10.7 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF1487) SnoaL_4 PF13577.6 EMD59398.1 - 3e-27 95.3 0.1 4.2e-27 94.8 0.1 1.2 1 0 0 1 1 1 1 SnoaL-like domain PAH PF02671.21 EMD59398.1 - 0.019 15.1 0.1 0.04 14.1 0.1 1.6 1 0 0 1 1 1 0 Paired amphipathic helix repeat DUF4200 PF13863.6 EMD59398.1 - 0.094 13.1 1.1 0.12 12.7 1.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) Trimer_CC PF08954.11 EMD59398.1 - 0.29 10.7 1.1 1.2 8.7 1.1 1.9 1 1 0 1 1 1 0 Trimerisation motif RPE65 PF03055.15 EMD59399.1 - 2.5e-100 336.9 0.0 3e-100 336.6 0.0 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein NmrA PF05368.13 EMD59400.1 - 1.4e-27 96.7 0.0 2.2e-27 96.1 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EMD59400.1 - 1.9e-06 27.9 0.0 2.7e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EMD59400.1 - 4.7e-05 23.0 0.2 0.00011 21.8 0.0 1.6 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EMD59400.1 - 0.016 14.2 0.0 0.024 13.7 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family HEAT_2 PF13646.6 EMD59401.1 - 3e-10 40.4 1.1 6.7 7.2 0.0 8.4 6 2 2 8 8 8 3 HEAT repeats HEAT PF02985.22 EMD59401.1 - 4.8e-08 32.6 9.1 6.9 7.2 0.1 9.2 9 0 0 9 9 9 2 HEAT repeat IFRD PF05004.13 EMD59401.1 - 0.0096 15.1 6.1 1.1 8.3 0.0 5.4 5 0 0 5 5 5 1 Interferon-related developmental regulator (IFRD) CLASP_N PF12348.8 EMD59401.1 - 0.048 13.2 5.2 60 3.1 0.0 6.0 6 1 0 6 6 6 0 CLASP N terminal HEAT_EZ PF13513.6 EMD59401.1 - 0.081 13.5 10.5 4.7 7.8 0.1 7.5 9 0 0 9 9 9 0 HEAT-like repeat Arm PF00514.23 EMD59401.1 - 0.33 11.1 1.5 21 5.3 0.1 4.4 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat Transcrip_reg PF01709.20 EMD59402.1 - 2.6e-73 246.4 0.4 3.1e-73 246.2 0.4 1.0 1 0 0 1 1 1 1 Transcriptional regulator Pet100 PF09803.9 EMD59403.1 - 7.3e-12 45.6 0.2 9e-12 45.3 0.2 1.1 1 0 0 1 1 1 1 Pet100 ECH_1 PF00378.20 EMD59404.1 - 5.1e-22 78.4 0.0 7.3e-22 77.9 0.0 1.4 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EMD59404.1 - 1.5e-12 47.7 0.0 1.9e-12 47.4 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase DUF1640 PF07798.11 EMD59405.1 - 6.7e-40 137.0 2.7 9.4e-40 136.5 2.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) DUF2353 PF09789.9 EMD59405.1 - 1.3 8.3 8.7 0.27 10.6 4.7 1.9 2 1 0 2 2 2 0 Uncharacterized coiled-coil protein (DUF2353) ATP11 PF06644.11 EMD59405.1 - 1.7 8.4 7.0 0.89 9.3 2.9 2.1 2 0 0 2 2 2 0 ATP11 protein UPF0561 PF10573.9 EMD59405.1 - 3.6 7.7 10.5 1.1 9.4 5.0 2.4 2 0 0 2 2 2 0 Uncharacterised protein family UPF0561 Uds1 PF15456.6 EMD59406.1 - 0.055 13.6 0.7 0.11 12.7 0.7 1.5 1 1 0 1 1 1 0 Up-regulated During Septation DUF3384 PF11864.8 EMD59408.1 - 3.3e-140 468.2 1.1 4.9e-140 467.6 1.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3384) Rap_GAP PF02145.15 EMD59408.1 - 3e-51 173.6 0.0 5.3e-51 172.8 0.0 1.4 1 0 0 1 1 1 1 Rap/ran-GAP Tuberin PF03542.16 EMD59408.1 - 4.2e-39 134.6 1.8 2.5e-34 118.9 0.6 3.5 3 0 0 3 3 3 3 Tuberin CAS_CSE1 PF03378.15 EMD59409.1 - 3.3e-188 625.7 1.4 4.8e-188 625.2 0.2 1.9 2 0 0 2 2 2 1 CAS/CSE protein, C-terminus Cse1 PF08506.10 EMD59409.1 - 4.6e-153 509.4 0.3 8.4e-153 508.6 0.3 1.4 1 0 0 1 1 1 1 Cse1 IBN_N PF03810.19 EMD59409.1 - 8.3e-17 60.9 0.0 3.2e-16 59.0 0.0 2.2 1 0 0 1 1 1 1 Importin-beta N-terminal domain Xpo1 PF08389.12 EMD59409.1 - 0.045 13.8 0.1 0.41 10.7 0.0 2.8 2 0 0 2 2 2 0 Exportin 1-like protein Mannitol_dh_C PF08125.13 EMD59410.1 - 2.2e-77 259.9 0.0 3.3e-77 259.3 0.0 1.3 1 0 0 1 1 1 1 Mannitol dehydrogenase C-terminal domain Mannitol_dh PF01232.23 EMD59410.1 - 4.3e-45 153.6 0.0 7.5e-45 152.8 0.0 1.4 1 0 0 1 1 1 1 Mannitol dehydrogenase Rossmann domain Ras PF00071.22 EMD59411.1 - 1e-47 161.7 0.0 6.8e-46 155.8 0.0 2.1 1 1 0 1 1 1 1 Ras family Roc PF08477.13 EMD59411.1 - 5.4e-29 100.8 0.0 1.7e-18 67.0 0.0 2.2 1 1 1 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMD59411.1 - 3.3e-11 43.0 0.0 3.1e-10 39.8 0.0 1.9 2 0 0 2 2 2 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EMD59411.1 - 1.4e-07 31.2 0.0 4.2e-07 29.7 0.0 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EMD59411.1 - 4.8e-05 22.8 0.0 7.1e-05 22.3 0.0 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EMD59411.1 - 0.00052 20.1 0.0 0.0025 17.9 0.0 2.1 2 1 0 2 2 2 1 50S ribosome-binding GTPase PduV-EutP PF10662.9 EMD59411.1 - 0.007 16.1 0.0 1 9.1 0.0 2.4 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation RsgA_GTPase PF03193.16 EMD59411.1 - 0.017 15.0 0.4 1.6 8.6 0.1 2.4 1 1 0 2 2 2 0 RsgA GTPase Choline_transpo PF04515.12 EMD59412.1 - 4.5e-26 91.8 15.6 4.5e-26 91.8 15.6 2.4 2 1 0 2 2 2 1 Plasma-membrane choline transporter GCP_N_terminal PF17681.1 EMD59413.1 - 9.9e-65 219.1 0.2 3.3e-64 217.4 0.0 1.8 2 0 0 2 2 2 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 EMD59413.1 - 3.8e-63 213.8 1.1 3.8e-63 213.8 1.1 1.6 2 0 0 2 2 2 1 Gamma tubulin complex component C-terminal adh_short PF00106.25 EMD59414.1 - 6.2e-24 84.5 0.5 3.7e-22 78.8 0.5 2.2 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD59414.1 - 4.2e-16 59.2 0.4 7.6e-14 51.8 0.3 2.2 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD59414.1 - 4.7e-07 29.9 0.1 1.4e-06 28.4 0.0 1.6 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 EMD59414.1 - 0.0013 18.3 0.1 0.0018 17.8 0.1 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EMD59414.1 - 0.056 12.8 0.0 0.12 11.7 0.0 1.6 1 1 0 1 1 1 0 GDP-mannose 4,6 dehydratase Phage_integrase PF00589.22 EMD59414.1 - 0.11 12.3 0.0 0.21 11.4 0.0 1.4 1 0 0 1 1 1 0 Phage integrase family HtaA PF04213.13 EMD59416.1 - 0.011 16.3 0.1 0.016 15.7 0.1 1.2 1 0 0 1 1 1 0 Htaa DUF3567 PF12091.8 EMD59416.1 - 0.14 12.3 0.0 0.36 11.0 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3567) Metallophos PF00149.28 EMD59417.1 - 3.2e-34 119.2 0.0 6e-34 118.3 0.0 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PPP5 PF08321.12 EMD59417.1 - 5.2e-33 113.2 0.8 1e-32 112.3 0.8 1.5 1 0 0 1 1 1 1 PPP5 TPR repeat region TPR_1 PF00515.28 EMD59417.1 - 2.8e-07 30.1 1.5 0.00038 20.1 0.2 2.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 EMD59417.1 - 5.8e-05 22.9 1.4 0.022 14.8 0.1 2.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 EMD59417.1 - 0.00053 19.6 3.1 0.00073 19.2 1.1 2.1 2 0 0 2 2 2 1 TPR repeat TPR_17 PF13431.6 EMD59417.1 - 0.0013 19.0 2.1 0.0032 17.8 0.1 2.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.6 EMD59417.1 - 0.032 14.4 0.8 0.1 12.9 0.1 2.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_20 PF14561.6 EMD59417.1 - 0.15 12.4 0.4 0.35 11.2 0.4 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat Spt4 PF06093.13 EMD59418.1 - 2.7e-31 107.5 0.3 3.2e-31 107.2 0.3 1.1 1 0 0 1 1 1 1 Spt4/RpoE2 zinc finger Coronavirus_5 PF05528.11 EMD59418.1 - 0.031 14.3 0.1 0.039 13.9 0.1 1.2 1 0 0 1 1 1 0 Coronavirus gene 5 protein Mito_carr PF00153.27 EMD59419.1 - 6.2e-42 141.4 9.0 1e-17 63.8 0.3 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Lipase_GDSL_2 PF13472.6 EMD59420.1 - 1.4e-21 77.7 0.4 2e-21 77.2 0.4 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EMD59420.1 - 1.5e-11 44.6 0.0 1.8e-11 44.4 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Glyco_hydro_3_C PF01915.22 EMD59420.1 - 0.097 12.6 0.0 0.15 12.0 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 3 C-terminal domain PI3K_1B_p101 PF10486.9 EMD59421.1 - 1.4 6.6 5.3 2.5 5.8 5.3 1.4 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit AMP-binding PF00501.28 EMD59422.1 - 1.3e-87 294.2 0.0 1.5e-87 293.9 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme Cys_Met_Meta_PP PF01053.20 EMD59423.1 - 8.4e-152 505.1 0.0 9.6e-152 504.9 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 EMD59423.1 - 1.7e-09 37.4 0.1 2.9e-09 36.7 0.1 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_1_2 PF00155.21 EMD59423.1 - 5.3e-09 35.7 0.0 9.6e-09 34.9 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 EMD59423.1 - 1e-08 34.6 0.5 2.1e-08 33.6 0.5 1.4 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 EMD59423.1 - 1.5e-08 34.3 0.0 2.4e-08 33.6 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Met_gamma_lyase PF06838.11 EMD59423.1 - 0.00029 19.5 0.1 0.00041 19.0 0.1 1.2 1 0 0 1 1 1 1 Methionine gamma-lyase GDC-P PF02347.16 EMD59423.1 - 0.084 11.7 0.0 0.12 11.2 0.0 1.1 1 0 0 1 1 1 0 Glycine cleavage system P-protein DUF3970 PF13113.6 EMD59423.1 - 0.085 13.1 0.1 0.4 10.9 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3970) CPSase_L_D2 PF02786.17 EMD59423.1 - 0.087 12.3 0.5 0.2 11.1 0.0 1.7 2 0 0 2 2 2 0 Carbamoyl-phosphate synthase L chain, ATP binding domain Asparaginase_C PF17763.1 EMD59423.1 - 0.13 12.5 0.0 0.42 10.8 0.0 1.8 1 0 0 1 1 1 0 Glutaminase/Asparaginase C-terminal domain DDOST_48kD PF03345.14 EMD59424.1 - 0.15 10.9 0.1 0.19 10.5 0.1 1.0 1 0 0 1 1 1 0 Oligosaccharyltransferase 48 kDa subunit beta Velvet PF11754.8 EMD59425.1 - 2e-51 175.4 0.0 7e-33 114.6 0.0 5.1 2 2 1 3 3 3 2 Velvet factor RTA1 PF04479.13 EMD59426.1 - 2e-45 154.9 2.9 2.8e-45 154.5 2.9 1.2 1 0 0 1 1 1 1 RTA1 like protein TRAPPC10 PF12584.8 EMD59427.1 - 2.6e-32 111.7 0.0 4.9e-32 110.8 0.0 1.5 1 0 0 1 1 1 1 Trafficking protein particle complex subunit 10, TRAPPC10 Foie-gras_1 PF11817.8 EMD59427.1 - 0.0067 16.0 0.2 0.014 15.0 0.2 1.5 1 0 0 1 1 1 1 Foie gras liver health family 1 Peptidase_S10 PF00450.22 EMD59428.1 - 3.3e-96 323.2 0.9 4.2e-96 322.9 0.9 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase nlz1 PF12402.8 EMD59428.1 - 0.091 13.2 0.3 0.28 11.6 0.3 1.8 1 0 0 1 1 1 0 NocA-like zinc-finger protein 1 Rep_fac_C PF08542.11 EMD59429.1 - 3e-25 88.4 0.3 2.2e-24 85.7 0.1 2.4 3 0 0 3 3 2 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.6 EMD59429.1 - 2.3e-12 47.0 0.0 9.8e-09 35.2 0.0 2.3 1 1 1 2 2 2 2 DNA polymerase III, delta subunit AAA PF00004.29 EMD59429.1 - 1.1e-10 42.1 0.0 1.8e-10 41.4 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 EMD59429.1 - 1e-06 28.8 0.0 2.5e-06 27.6 0.0 1.6 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EMD59429.1 - 8.2e-06 26.3 0.0 0.00046 20.6 0.0 2.4 1 1 1 2 2 2 1 AAA ATPase domain Viral_helicase1 PF01443.18 EMD59429.1 - 3.1e-05 23.9 0.0 4.9e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase AAA_22 PF13401.6 EMD59429.1 - 6.8e-05 23.2 0.0 0.092 13.0 0.0 2.5 1 1 1 2 2 2 2 AAA domain RuvB_N PF05496.12 EMD59429.1 - 0.0002 21.1 0.0 0.00049 19.9 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain DNA_pol3_delta PF06144.13 EMD59429.1 - 0.00029 20.7 0.0 0.00042 20.1 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA_3 PF07726.11 EMD59429.1 - 0.00037 20.4 0.0 0.00074 19.4 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 EMD59429.1 - 0.0018 18.3 0.0 0.0033 17.4 0.0 1.4 1 0 0 1 1 1 1 Rad17 P-loop domain Mg_chelatase PF01078.21 EMD59429.1 - 0.002 17.5 0.0 0.014 14.8 0.0 2.0 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_assoc_2 PF16193.5 EMD59429.1 - 0.006 16.9 0.0 0.018 15.4 0.0 1.9 1 1 0 1 1 1 1 AAA C-terminal domain AAA_19 PF13245.6 EMD59429.1 - 0.0087 16.4 0.1 0.04 14.2 0.1 2.3 1 1 0 1 1 1 1 AAA domain AAA_11 PF13086.6 EMD59429.1 - 0.013 15.3 0.0 0.018 14.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain MeaB PF03308.16 EMD59429.1 - 0.013 14.5 0.0 0.024 13.6 0.0 1.4 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB TniB PF05621.11 EMD59429.1 - 0.019 14.4 0.0 2 7.8 0.0 2.4 2 0 0 2 2 2 0 Bacterial TniB protein AAA_24 PF13479.6 EMD59429.1 - 0.023 14.4 0.0 0.18 11.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 EMD59429.1 - 0.025 14.3 0.1 0.076 12.7 0.1 1.8 1 1 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 EMD59429.1 - 0.049 13.5 0.0 0.17 11.8 0.0 2.0 2 0 0 2 2 2 0 NTPase DEAD PF00270.29 EMD59429.1 - 0.05 13.4 0.1 1 9.1 0.0 2.4 1 1 1 2 2 2 0 DEAD/DEAH box helicase AAA_25 PF13481.6 EMD59429.1 - 0.13 11.8 0.1 1.2 8.7 0.0 2.3 2 1 1 3 3 3 0 AAA domain Asp PF00026.23 EMD59430.1 - 2.7e-74 250.4 0.2 3.3e-74 250.1 0.2 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EMD59430.1 - 2.6e-13 50.6 2.2 5.3e-11 43.1 1.5 3.1 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EMD59430.1 - 2e-06 28.3 0.0 0.68 10.6 0.0 3.6 3 0 0 3 3 3 2 Aspartyl protease TAXi_C PF14541.6 EMD59430.1 - 0.0025 17.6 0.0 0.048 13.4 0.0 2.4 2 1 0 2 2 2 1 Xylanase inhibitor C-terminal gag-asp_proteas PF13975.6 EMD59430.1 - 0.084 13.4 0.0 5 7.8 0.0 3.1 2 1 0 2 2 2 0 gag-polyprotein putative aspartyl protease FA_desaturase PF00487.24 EMD59432.1 - 1.1e-30 107.4 23.9 1.7e-30 106.7 23.9 1.3 1 0 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.28 EMD59432.1 - 2.9e-11 43.4 0.0 5.3e-11 42.5 0.0 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Cupin_1 PF00190.22 EMD59433.1 - 1.7e-41 141.4 0.0 1.3e-21 76.8 0.0 2.1 2 0 0 2 2 2 2 Cupin Cupin_2 PF07883.11 EMD59433.1 - 2e-25 88.3 0.9 7.3e-12 44.8 0.1 2.4 2 0 0 2 2 2 2 Cupin domain Cupin_3 PF05899.12 EMD59433.1 - 4.5e-10 39.1 0.0 0.00018 21.2 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF861) AraC_binding PF02311.19 EMD59433.1 - 2.8e-06 27.3 0.2 0.00093 19.1 0.1 2.4 2 0 0 2 2 2 2 AraC-like ligand binding domain ARD PF03079.14 EMD59433.1 - 0.013 15.7 0.4 2.9 8.0 0.0 2.5 2 0 0 2 2 2 0 ARD/ARD' family DUF1275 PF06912.11 EMD59434.1 - 5.3e-47 160.2 14.9 6.5e-47 159.9 14.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1275) Mito_carr PF00153.27 EMD59435.1 - 9.6e-28 96.0 2.9 6.6e-12 45.2 0.0 3.4 3 0 0 3 3 3 3 Mitochondrial carrier protein CRT10 PF08728.10 EMD59435.1 - 6e-12 44.6 0.0 5.1e-08 31.6 0.0 2.1 2 0 0 2 2 2 2 CRT10 Citrate_synt PF00285.21 EMD59436.1 - 8.7e-103 344.1 0.0 1.1e-102 343.8 0.0 1.0 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain Eclosion PF04736.12 EMD59436.1 - 0.1 12.3 0.0 0.18 11.5 0.0 1.3 1 0 0 1 1 1 0 Eclosion hormone CTD_bind PF04818.13 EMD59437.1 - 2.5e-08 34.6 0.0 5.2e-08 33.6 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase II-binding domain. RRM_1 PF00076.22 EMD59437.1 - 1.2e-06 28.2 0.0 3.1e-06 26.9 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DprA_WH PF17782.1 EMD59437.1 - 1.6 8.9 5.8 4 7.6 0.6 2.8 2 0 0 2 2 2 0 DprA winged helix domain CLPTM1 PF05602.12 EMD59438.1 - 2.5e-156 521.0 0.4 3.1e-156 520.7 0.4 1.1 1 0 0 1 1 1 1 Cleft lip and palate transmembrane protein 1 (CLPTM1) DUF1772 PF08592.11 EMD59438.1 - 1.6 9.0 4.8 2.4 8.5 0.0 3.2 3 1 1 4 4 4 0 Domain of unknown function (DUF1772) 2TM PF13239.6 EMD59438.1 - 6.2 7.2 6.2 3.2 8.1 0.4 2.9 2 1 0 2 2 2 0 2TM domain Lysine_decarbox PF03641.14 EMD59439.1 - 2.7e-29 101.9 0.0 3.7e-29 101.5 0.0 1.2 1 0 0 1 1 1 1 Possible lysine decarboxylase LDcluster4 PF18306.1 EMD59439.1 - 0.00016 21.3 0.5 0.00033 20.3 0.5 1.5 1 1 0 1 1 1 1 SLOG cluster4 family MAPEG PF01124.18 EMD59440.1 - 5.6e-11 42.5 4.9 9e-11 41.8 4.9 1.3 1 0 0 1 1 1 1 MAPEG family Aminotran_3 PF00202.21 EMD59441.1 - 4.1e-117 391.3 0.0 4.7e-117 391.1 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III SRI PF08236.11 EMD59442.1 - 6.6e-19 67.9 12.0 6.6e-19 67.9 12.0 1.9 2 0 0 2 2 2 1 SRI (Set2 Rpb1 interacting) domain SET PF00856.28 EMD59442.1 - 2.9e-18 66.8 1.5 7.5e-18 65.5 0.1 2.5 2 1 0 2 2 2 1 SET domain AWS PF17907.1 EMD59442.1 - 7e-11 42.0 11.3 7e-11 42.0 11.3 2.4 2 0 0 2 2 2 1 AWS domain Med26 PF08711.11 EMD59442.1 - 1e-07 31.9 1.9 7e-07 29.2 0.1 2.8 2 0 0 2 2 2 1 TFIIS helical bundle-like domain WW PF00397.26 EMD59442.1 - 5.3e-06 26.4 0.7 1.2e-05 25.3 0.7 1.7 1 0 0 1 1 1 1 WW domain DUF2956 PF11169.8 EMD59442.1 - 0.74 10.0 6.3 1.2 9.4 2.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2956) GLTSCR1 PF15249.6 EMD59442.1 - 1.3 9.5 4.9 0.69 10.4 0.0 2.9 3 0 0 3 3 3 0 Conserved region of unknown function on GLTSCR protein PRIMA1 PF16101.5 EMD59442.1 - 4.2 7.4 11.5 0.22 11.5 4.6 2.5 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 VEFS-Box PF09733.9 EMD59444.1 - 1.6e-08 34.5 0.1 2.7e-08 33.7 0.1 1.4 1 0 0 1 1 1 1 VEFS-Box of polycomb protein LRR_4 PF12799.7 EMD59445.1 - 0.0034 17.8 4.7 0.087 13.3 0.1 4.0 4 1 0 4 4 4 1 Leucine Rich repeats (2 copies) F-box-like PF12937.7 EMD59445.1 - 0.0062 16.4 0.1 0.0062 16.4 0.1 2.1 2 0 0 2 2 2 1 F-box-like RNase_P_Rpp14 PF01900.19 EMD59447.1 - 0.047 13.9 0.0 0.058 13.6 0.0 1.2 1 0 0 1 1 1 0 Rpp14/Pop5 family SesA PF17107.5 EMD59448.1 - 0.0026 17.9 20.2 0.18 12.0 0.1 6.4 4 4 3 7 7 7 2 N-terminal domain on NACHT_NTPase and P-loop NTPases DUF3209 PF11483.8 EMD59448.1 - 0.028 14.9 0.6 0.028 14.9 0.6 4.5 4 1 0 4 4 4 0 Protein of unknown function (DUF3209) HEPN_Swt1 PF18731.1 EMD59448.1 - 0.068 13.5 1.6 0.41 11.0 0.4 3.0 2 1 1 3 3 3 0 Swt1-like HEPN DUF1993 PF09351.10 EMD59448.1 - 0.12 12.6 15.7 2.7 8.1 0.1 4.6 4 0 0 4 4 4 0 Domain of unknown function (DUF1993) Pox_A_type_inc PF04508.12 EMD59448.1 - 0.15 12.0 2.2 13 5.8 0.7 3.8 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat DUF16 PF01519.16 EMD59448.1 - 0.19 12.2 0.1 0.19 12.2 0.1 7.6 3 1 1 6 6 5 0 Protein of unknown function DUF16 DUF1664 PF07889.12 EMD59448.1 - 1.4 9.0 37.7 1.9 8.5 0.5 7.7 4 3 2 6 6 6 0 Protein of unknown function (DUF1664) Sugarporin_N PF11471.8 EMD59448.1 - 1.5 8.8 9.1 5.1 7.1 0.2 3.8 3 0 0 3 3 3 0 Maltoporin periplasmic N-terminal extension FlaC_arch PF05377.11 EMD59448.1 - 2.7 8.5 31.4 15 6.0 0.0 9.4 10 2 1 11 11 10 0 Flagella accessory protein C (FlaC) End3 PF12761.7 EMD59448.1 - 4.4 7.4 39.7 0.51 10.5 2.1 5.2 3 3 2 5 5 5 0 Actin cytoskeleton-regulatory complex protein END3 Fzo_mitofusin PF04799.13 EMD59448.1 - 5.8 6.4 33.2 0.82 9.2 2.9 6.7 5 3 2 7 7 7 0 fzo-like conserved region TIP49 PF06068.13 EMD59449.1 - 1.9e-152 507.5 2.2 2.4e-152 507.2 2.2 1.1 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 EMD59449.1 - 4.3e-21 74.8 0.2 3.4e-20 71.9 0.1 2.6 3 0 0 3 3 3 1 TIP49 AAA-lid domain RuvB_N PF05496.12 EMD59449.1 - 5.7e-09 35.9 0.3 4.9e-05 23.1 0.0 2.3 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA PF00004.29 EMD59449.1 - 4.2e-08 33.7 0.6 7.2e-05 23.2 0.1 2.8 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) DnaB_C PF03796.15 EMD59449.1 - 2e-06 27.3 0.5 3.6e-06 26.5 0.5 1.3 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain AAA_16 PF13191.6 EMD59449.1 - 3.4e-05 24.3 0.1 0.00011 22.6 0.1 2.0 1 1 0 1 1 1 1 AAA ATPase domain Mg_chelatase PF01078.21 EMD59449.1 - 0.00052 19.4 1.0 0.0096 15.3 0.4 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EMD59449.1 - 0.00093 19.2 1.2 0.63 10.0 0.0 3.5 2 2 1 3 3 3 1 AAA domain (dynein-related subfamily) AAA_11 PF13086.6 EMD59449.1 - 0.007 16.2 1.0 0.19 11.5 1.0 2.2 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EMD59449.1 - 0.013 15.8 0.0 0.81 10.0 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.6 EMD59449.1 - 0.013 15.8 1.9 0.31 11.4 1.9 2.4 1 1 0 1 1 1 0 AAA domain Parvo_NS1 PF01057.17 EMD59449.1 - 0.06 12.4 0.0 0.09 11.8 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_25 PF13481.6 EMD59449.1 - 0.067 12.8 0.1 0.14 11.7 0.1 1.4 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EMD59449.1 - 0.077 13.1 0.0 0.21 11.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 EMD59449.1 - 0.08 12.6 0.1 9.5 5.9 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain LicD PF04991.13 EMD59450.1 - 2.3e-21 77.0 11.9 9.3e-16 58.7 2.0 2.5 2 1 1 3 3 3 2 LicD family DDE_1 PF03184.19 EMD59451.1 - 3.5e-17 62.6 0.0 1.7e-07 31.1 0.0 2.4 1 1 1 2 2 2 2 DDE superfamily endonuclease Y1_Tnp PF01797.16 EMD59451.1 - 0.003 17.7 1.1 0.0059 16.7 1.1 1.4 1 0 0 1 1 1 1 Transposase IS200 like NACHT PF05729.12 EMD59452.1 - 2.8e-26 92.4 0.1 4.5e-26 91.7 0.1 1.3 1 0 0 1 1 1 1 NACHT domain HET PF06985.11 EMD59452.1 - 4.1e-15 56.4 0.6 1.1e-14 55.0 0.6 1.8 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) AAA_16 PF13191.6 EMD59452.1 - 0.012 16.0 0.0 0.025 14.9 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain AAA_19 PF13245.6 EMD59452.1 - 0.024 15.0 0.0 0.049 14.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain WLM PF08325.10 EMD59453.1 - 1.1e-51 175.7 0.0 1.9e-51 174.9 0.0 1.3 1 0 0 1 1 1 1 WLM domain ubiquitin PF00240.23 EMD59453.1 - 0.00015 21.4 0.1 0.0011 18.6 0.0 2.1 2 0 0 2 2 2 1 Ubiquitin family SprT-like PF10263.9 EMD59453.1 - 0.0016 18.3 0.0 0.003 17.4 0.0 1.6 1 0 0 1 1 1 1 SprT-like family DUF45 PF01863.17 EMD59453.1 - 0.012 15.7 0.1 0.023 14.7 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function DUF45 Oxidored_FMN PF00724.20 EMD59455.1 - 5.4e-42 144.3 0.0 6.9e-42 143.9 0.0 1.1 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Sugar_tr PF00083.24 EMD59457.1 - 8.9e-112 374.2 24.4 1.1e-111 374.0 24.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD59457.1 - 4.5e-14 52.1 46.3 9.8e-11 41.2 14.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Coagulin PF02035.15 EMD59457.1 - 0.18 11.7 0.0 0.32 10.9 0.0 1.3 1 0 0 1 1 1 0 Coagulin Ribosomal_L28e PF01778.17 EMD59458.1 - 6.7e-34 117.1 0.1 1.1e-33 116.3 0.1 1.4 1 0 0 1 1 1 1 Ribosomal L28e protein family Mak16 PF04874.14 EMD59458.1 - 1.5e-28 99.3 7.7 1.5e-28 99.3 7.7 2.3 2 0 0 2 2 2 1 Mak16 protein C-terminal region BUD22 PF09073.10 EMD59458.1 - 0.00012 21.6 8.7 0.00014 21.3 8.7 1.1 1 0 0 1 1 1 1 BUD22 DNA_pol_phi PF04931.13 EMD59458.1 - 0.14 10.2 17.2 0.2 9.7 17.2 1.1 1 0 0 1 1 1 0 DNA polymerase phi SDA1 PF05285.12 EMD59458.1 - 0.76 9.1 15.4 1 8.7 15.4 1.2 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 EMD59458.1 - 0.81 7.8 18.0 0.16 10.1 14.7 1.5 2 0 0 2 2 2 0 Nop14-like family Cwf_Cwc_15 PF04889.12 EMD59458.1 - 9 5.9 22.5 20 4.8 22.5 1.7 1 1 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein TrmE_N PF10396.9 EMD59459.1 - 2e-35 121.6 0.0 5.5e-35 120.2 0.0 1.8 1 0 0 1 1 1 1 GTP-binding protein TrmE N-terminus MnmE_helical PF12631.7 EMD59459.1 - 1.6e-32 113.3 0.2 2.3e-32 112.9 0.2 1.2 1 0 0 1 1 1 1 MnmE helical domain MMR_HSR1 PF01926.23 EMD59459.1 - 7.2e-20 71.2 0.2 1.2e-19 70.4 0.2 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EMD59459.1 - 2.9e-09 36.6 0.1 4.7e-09 36.0 0.1 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B GTP_EFTU PF00009.27 EMD59459.1 - 1.2e-06 28.2 0.2 0.00014 21.5 0.1 2.4 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 EMD59459.1 - 3.2e-06 27.3 0.4 3.7e-05 23.9 0.0 2.2 1 1 1 2 2 2 1 Dynamin family RsgA_GTPase PF03193.16 EMD59459.1 - 0.00061 19.7 0.2 0.073 13.0 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase TnpB_IS66 PF05717.13 EMD59459.1 - 0.0053 16.6 0.0 0.0099 15.8 0.0 1.4 1 0 0 1 1 1 1 IS66 Orf2 like protein ABC_tran PF00005.27 EMD59459.1 - 0.044 14.3 0.3 0.13 12.8 0.3 1.9 1 1 0 1 1 1 0 ABC transporter AAA_24 PF13479.6 EMD59459.1 - 0.088 12.5 0.1 0.22 11.2 0.0 1.7 2 0 0 2 2 2 0 AAA domain Roc PF08477.13 EMD59459.1 - 0.21 11.8 0.4 1.1 9.5 0.0 2.1 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Hus1 PF04005.12 EMD59461.1 - 1.1e-95 320.2 0.0 1.2e-95 320.0 0.0 1.0 1 0 0 1 1 1 1 Hus1-like protein Peptidase_A4 PF01828.17 EMD59462.1 - 2e-40 138.5 7.4 2.3e-40 138.3 7.4 1.0 1 0 0 1 1 1 1 Peptidase A4 family DUF1996 PF09362.10 EMD59463.1 - 4.5e-82 275.5 2.5 5.5e-82 275.3 2.5 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1996) DUF4818 PF16089.5 EMD59464.1 - 0.036 14.5 6.3 0.12 12.8 6.3 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4818) RNase_HII PF01351.18 EMD59466.1 - 2.1e-47 161.6 0.0 7.3e-47 159.8 0.0 1.7 1 1 0 1 1 1 1 Ribonuclease HII adh_short PF00106.25 EMD59467.1 - 2.4e-40 138.1 0.0 3.5e-40 137.6 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD59467.1 - 9.7e-27 94.0 0.0 1.7e-26 93.2 0.0 1.4 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD59467.1 - 3.2e-13 50.0 0.5 9.9e-13 48.4 0.5 1.7 1 1 0 1 1 1 1 KR domain 3Beta_HSD PF01073.19 EMD59467.1 - 4.1e-05 22.7 0.0 6.2e-05 22.1 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EMD59467.1 - 0.0025 17.3 0.0 0.0045 16.5 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF1776 PF08643.10 EMD59467.1 - 0.0056 16.1 0.3 0.0099 15.3 0.3 1.4 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) PUF PF00806.19 EMD59469.1 - 2.1e-63 206.6 13.4 7.2e-09 34.9 0.0 8.4 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat Dehyd-heme_bind PF09098.10 EMD59469.1 - 0.08 12.6 0.0 0.2 11.3 0.0 1.6 1 0 0 1 1 1 0 Quinohemoprotein amine dehydrogenase A, alpha subunit, haem binding Inhibitor_I9 PF05922.16 EMD59470.1 - 0.0017 19.0 0.0 0.0019 18.8 0.0 1.1 1 0 0 1 1 1 1 Peptidase inhibitor I9 Peptidase_M28 PF04389.17 EMD59473.1 - 3.6e-31 108.4 0.0 6e-31 107.7 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 EMD59473.1 - 0.00094 18.9 0.0 0.0014 18.3 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Carn_acyltransf PF00755.20 EMD59474.1 - 4.7e-209 695.9 0.0 6.2e-209 695.5 0.0 1.2 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase zf-rbx1 PF12678.7 EMD59474.1 - 0.1 12.9 0.2 0.26 11.6 0.2 1.7 1 0 0 1 1 1 0 RING-H2 zinc finger domain RecA PF00154.21 EMD59475.1 - 0.086 12.3 0.0 0.14 11.6 0.0 1.4 1 1 1 2 2 2 0 recA bacterial DNA recombination protein Rad51 PF08423.11 EMD59475.1 - 0.11 11.7 0.0 0.11 11.7 0.0 1.2 1 0 0 1 1 1 0 Rad51 PMT PF02366.18 EMD59476.1 - 9.5e-88 293.9 13.8 9.5e-88 293.9 13.8 2.4 2 1 1 3 3 3 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 EMD59476.1 - 3.5e-65 219.3 16.3 3.5e-65 219.3 16.3 2.3 2 1 0 2 2 2 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 EMD59476.1 - 1.2e-33 116.5 1.0 1.8e-33 115.9 1.0 1.2 1 0 0 1 1 1 1 MIR domain Sugar_tr PF00083.24 EMD59477.1 - 2.3e-106 356.4 16.3 2.8e-106 356.1 16.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD59477.1 - 2.5e-30 105.6 25.6 4.4e-29 101.5 19.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 EMD59477.1 - 0.0026 16.7 8.4 0.36 9.6 3.7 2.4 1 1 1 2 2 2 2 MFS_1 like family Chs7 PF12271.8 EMD59478.1 - 3e-108 361.5 6.7 3.5e-108 361.3 6.7 1.0 1 0 0 1 1 1 1 Chitin synthase export chaperone FixQ PF05545.11 EMD59478.1 - 5.6 7.0 13.2 3.7 7.6 0.1 4.0 3 1 0 3 3 3 0 Cbb3-type cytochrome oxidase component FixQ Ssl1 PF04056.14 EMD59479.1 - 8.9e-63 211.6 0.1 1.3e-60 204.6 0.0 2.1 1 1 1 2 2 2 2 Ssl1-like VWA_2 PF13519.6 EMD59479.1 - 9.7e-15 55.1 0.0 2.2e-14 54.0 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain C1_4 PF07975.12 EMD59479.1 - 1.3e-14 54.2 10.8 1.3e-14 54.2 10.8 3.7 2 2 1 3 3 3 1 TFIIH C1-like domain VWA PF00092.28 EMD59479.1 - 2.5e-05 24.6 0.0 4e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain DUF4769 PF15992.5 EMD59479.1 - 0.084 12.7 2.3 0.12 12.2 0.8 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4769) Tfb4 PF03850.14 EMD59479.1 - 0.11 11.9 4.0 0.27 10.7 4.0 1.7 1 0 0 1 1 1 0 Transcription factor Tfb4 zf-HIT PF04438.16 EMD59479.1 - 7.2 6.6 27.6 0.036 13.9 4.8 3.9 5 0 0 5 5 5 0 HIT zinc finger FAA_hydrolase PF01557.18 EMD59480.1 - 1.3e-64 217.8 0.0 1.7e-64 217.5 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family DUF2437 PF10370.9 EMD59480.1 - 0.025 15.4 0.0 0.055 14.4 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF2437) HLH PF00010.26 EMD59483.1 - 9e-13 48.0 0.5 1.6e-12 47.1 0.5 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Pox_A30L_A26L PF06086.12 EMD59483.1 - 0.028 14.1 0.1 0.045 13.4 0.1 1.3 1 0 0 1 1 1 0 Orthopoxvirus A26L/A30L protein F-112 PF09645.10 EMD59483.1 - 7.8 6.7 8.4 1.1 9.4 3.2 2.2 2 1 0 2 2 2 0 F-112 protein DUF3402 PF11882.8 EMD59484.1 - 1.2e-190 634.5 0.1 1.6e-190 634.1 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3402) N1221 PF07923.13 EMD59484.1 - 1.5e-85 286.9 0.0 2.2e-85 286.4 0.0 1.3 1 0 0 1 1 1 1 N1221-like protein FMN_dh PF01070.18 EMD59485.1 - 2.1e-107 359.2 0.0 2.5e-107 358.9 0.0 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.28 EMD59485.1 - 2.4e-19 69.2 0.0 4.9e-19 68.2 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Glu_synthase PF01645.17 EMD59485.1 - 9.2e-07 28.3 0.1 1.5e-06 27.6 0.1 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.25 EMD59485.1 - 1.1e-05 24.6 0.4 0.00031 19.8 0.1 2.6 2 1 1 3 3 3 1 IMP dehydrogenase / GMP reductase domain Tugs PF17840.1 EMD59485.1 - 0.0068 16.6 1.1 0.018 15.2 0.1 2.1 2 0 0 2 2 2 1 Tethering Ubl4a to BAGS domain NMO PF03060.15 EMD59485.1 - 0.01 15.3 0.2 0.017 14.5 0.2 1.3 1 0 0 1 1 1 0 Nitronate monooxygenase His_biosynth PF00977.21 EMD59485.1 - 0.039 13.4 0.0 0.097 12.1 0.0 1.6 2 0 0 2 2 2 0 Histidine biosynthesis protein Ribul_P_3_epim PF00834.19 EMD59485.1 - 0.11 11.9 0.0 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 Ribulose-phosphate 3 epimerase family DUF3043 PF11241.8 EMD59486.1 - 0.0073 16.4 4.0 0.019 15.0 4.0 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF3043) Glyco_hydro_43 PF04616.14 EMD59488.1 - 1e-66 225.2 1.2 1.4e-66 224.8 1.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 GH43_C2 PF17851.1 EMD59488.1 - 9.1e-35 120.2 0.0 1.3e-34 119.7 0.0 1.2 1 0 0 1 1 1 1 Beta xylosidase C-terminal Concanavalin A-like domain DUF1996 PF09362.10 EMD59489.1 - 9.5e-82 274.5 1.0 1.2e-81 274.2 1.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1996) MFS_1 PF07690.16 EMD59490.1 - 4.5e-34 117.9 21.6 4.5e-34 117.9 21.6 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EMD59490.1 - 3.9e-11 42.5 3.6 3.9e-11 42.5 3.6 2.2 3 0 0 3 3 3 1 Sugar (and other) transporter adh_short PF00106.25 EMD59491.1 - 1.3e-49 168.3 1.5 1.6e-49 168.0 1.5 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD59491.1 - 1.5e-45 155.6 1.8 9.6e-45 152.9 1.8 1.8 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 EMD59491.1 - 1.6e-05 24.5 0.0 3.1e-05 23.6 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family KR PF08659.10 EMD59491.1 - 2.2e-05 24.4 2.1 9.7e-05 22.3 2.1 1.8 1 1 0 1 1 1 1 KR domain Eno-Rase_NADH_b PF12242.8 EMD59491.1 - 0.024 14.4 0.1 0.074 12.8 0.1 1.8 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase ADH_zinc_N PF00107.26 EMD59491.1 - 0.067 13.2 0.0 0.16 12.0 0.0 1.6 2 0 0 2 2 2 0 Zinc-binding dehydrogenase G3P_antiterm PF04309.12 EMD59491.1 - 0.09 12.2 0.0 0.25 10.7 0.0 1.7 2 0 0 2 2 2 0 Glycerol-3-phosphate responsive antiterminator LysM PF01476.20 EMD59493.1 - 0.0015 18.5 0.0 0.0024 17.9 0.0 1.3 1 0 0 1 1 1 1 LysM domain OMPdecase PF00215.24 EMD59494.1 - 0.13 11.8 0.0 0.16 11.6 0.0 1.1 1 0 0 1 1 1 0 Orotidine 5'-phosphate decarboxylase / HUMPS family Alpha_L_fucos PF01120.17 EMD59495.1 - 1.9e-86 290.7 2.8 2.6e-86 290.2 2.8 1.1 1 0 0 1 1 1 1 Alpha-L-fucosidase PAN_4 PF14295.6 EMD59497.1 - 1.8e-11 43.7 12.8 6.1e-07 29.2 0.4 3.3 3 0 0 3 3 3 2 PAN domain PAN_2 PF08276.11 EMD59497.1 - 0.00024 21.1 7.2 0.034 14.2 0.6 2.9 2 0 0 2 2 2 2 PAN-like domain PAN_3 PF08277.12 EMD59497.1 - 0.083 12.7 12.0 0.35 10.7 0.8 3.0 3 0 0 3 3 3 0 PAN-like domain CVNH PF08881.10 EMD59498.1 - 1.5e-07 32.0 2.8 5.7e-05 23.7 0.9 2.1 1 1 1 2 2 2 2 CVNH domain TGBp3 PF02495.17 EMD59498.1 - 0.037 13.7 0.2 0.056 13.1 0.2 1.3 1 0 0 1 1 1 0 Triple gene block 3 HIPIP PF01355.17 EMD59498.1 - 0.039 14.3 0.5 0.067 13.5 0.5 1.4 1 0 0 1 1 1 0 High potential iron-sulfur protein SNF2_N PF00176.23 EMD59499.1 - 1.6e-62 211.3 0.1 2.7e-62 210.5 0.1 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EMD59499.1 - 5.3e-19 68.6 0.0 7.5e-18 64.9 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EMD59499.1 - 3.6e-09 36.8 0.1 1.3e-08 35.0 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit HSA PF07529.13 EMD59499.1 - 5.5e-08 33.0 3.9 2.1e-07 31.2 3.9 2.1 1 0 0 1 1 1 1 HSA DEAD PF00270.29 EMD59499.1 - 0.00011 22.0 0.0 0.00025 20.9 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase DEAD_2 PF06733.15 EMD59499.1 - 0.01 15.5 0.0 0.029 14.0 0.0 1.7 1 0 0 1 1 1 0 DEAD_2 NDUF_B8 PF05821.11 EMD59500.1 - 0.00011 22.1 1.8 0.00015 21.6 1.8 1.3 1 1 0 1 1 1 1 NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8) Membr_traf_MHD PF10540.9 EMD59501.1 - 1.1e-21 77.6 1.5 5.8e-19 68.7 0.5 3.0 2 1 0 2 2 2 1 Munc13 (mammalian uncoordinated) homology domain C2 PF00168.30 EMD59501.1 - 2.1e-15 56.9 0.0 4.6e-15 55.8 0.0 1.5 1 0 0 1 1 1 1 C2 domain HLH PF00010.26 EMD59502.1 - 1.2e-06 28.4 0.2 1.9e-06 27.7 0.2 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Methyltransf_16 PF10294.9 EMD59503.1 - 0.21 11.3 0.0 3.4 7.4 0.0 2.3 2 1 0 2 2 2 0 Lysine methyltransferase Presenilin PF01080.17 EMD59504.1 - 0.026 13.3 0.8 0.038 12.7 0.8 1.3 1 0 0 1 1 1 0 Presenilin YL1 PF05764.13 EMD59504.1 - 1.5 8.8 13.9 2.8 8.0 13.9 1.3 1 0 0 1 1 1 0 YL1 nuclear protein tRNA-synt_2b PF00587.25 EMD59505.1 - 2.6e-35 122.0 0.0 7.5e-34 117.2 0.0 2.2 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 EMD59505.1 - 2.4e-07 30.8 0.0 5e-07 29.8 0.0 1.5 1 0 0 1 1 1 1 Anticodon binding domain ADH_N PF08240.12 EMD59506.1 - 4.1e-26 91.0 0.7 4.1e-26 91.0 0.7 2.1 3 0 0 3 3 3 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EMD59506.1 - 1e-16 61.1 0.0 1.5e-16 60.6 0.0 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EMD59506.1 - 7.5e-06 25.6 0.2 0.00069 19.2 0.1 2.3 2 0 0 2 2 2 2 Glucose dehydrogenase C-terminus Pyr_redox_3 PF13738.6 EMD59506.1 - 0.22 10.7 0.2 2 7.6 0.3 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_8 PF08022.12 EMD59507.1 - 1.8e-24 85.9 0.0 3.6e-24 84.9 0.0 1.5 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.12 EMD59507.1 - 4.2e-22 78.9 0.0 6.5e-22 78.3 0.0 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.19 EMD59507.1 - 1.4e-19 70.4 12.0 1.4e-19 70.4 12.0 2.2 1 1 1 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_1 PF00175.21 EMD59507.1 - 0.18 12.4 0.0 4.1 8.1 0.0 2.3 2 0 0 2 2 2 0 Oxidoreductase NAD-binding domain ADH_N PF08240.12 EMD59509.1 - 1.7e-32 111.5 1.6 1.8e-32 111.5 0.2 1.7 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EMD59509.1 - 3.3e-23 82.1 0.2 7.5e-23 80.9 0.1 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EMD59509.1 - 1.1e-09 38.1 0.1 2e-09 37.3 0.1 1.4 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 EMD59509.1 - 0.00063 20.8 0.0 0.0011 20.0 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 EMD59509.1 - 0.00098 18.5 0.3 0.0015 17.8 0.3 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain UDPG_MGDP_dh_N PF03721.14 EMD59509.1 - 0.0013 18.4 0.0 0.0019 17.8 0.0 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Pyr_redox_2 PF07992.14 EMD59509.1 - 0.0031 16.8 0.1 0.0053 16.0 0.1 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EMD59509.1 - 0.12 11.0 0.1 0.17 10.5 0.1 1.2 1 0 0 1 1 1 0 HI0933-like protein AdoHcyase_NAD PF00670.21 EMD59509.1 - 0.15 12.1 1.5 0.57 10.2 1.5 2.0 1 1 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain VPS28 PF03997.12 EMD59510.1 - 1.1e-66 224.1 0.3 1.5e-66 223.7 0.3 1.2 1 0 0 1 1 1 1 VPS28 protein Methyltransf_16 PF10294.9 EMD59510.1 - 4.9e-23 81.7 0.0 5.4e-22 78.4 0.0 2.3 2 0 0 2 2 2 1 Lysine methyltransferase Methyltransf_23 PF13489.6 EMD59510.1 - 5.9e-06 26.2 0.0 1.5e-05 24.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain C-C_Bond_Lyase PF15617.6 EMD59510.1 - 0.065 12.4 0.3 0.15 11.2 0.0 1.6 2 0 0 2 2 2 0 C-C_Bond_Lyase of the TIM-Barrel fold Noc2 PF03715.13 EMD59511.1 - 2.2e-130 434.2 0.0 3.8e-130 433.5 0.0 1.4 1 0 0 1 1 1 1 Noc2p family Nop14 PF04147.12 EMD59511.1 - 0.019 13.2 0.1 0.019 13.2 0.1 3.2 2 1 0 3 3 3 0 Nop14-like family SAD_SRA PF02182.17 EMD59512.1 - 1.8e-32 112.2 0.1 4e-32 111.1 0.1 1.6 1 0 0 1 1 1 1 SAD/SRA domain PAF-AH_p_II PF03403.13 EMD59513.1 - 4e-45 153.9 0.0 6.4e-44 150.0 0.0 2.0 1 1 0 1 1 1 1 Platelet-activating factor acetylhydrolase, isoform II Chlorophyllase2 PF12740.7 EMD59513.1 - 8.7e-07 28.1 0.0 4.5e-06 25.8 0.0 1.9 2 0 0 2 2 2 1 Chlorophyllase enzyme Chlorophyllase PF07224.11 EMD59513.1 - 0.00036 19.6 0.0 0.00075 18.6 0.0 1.4 1 0 0 1 1 1 1 Chlorophyllase Hydrolase_4 PF12146.8 EMD59513.1 - 0.00041 19.7 0.5 0.0044 16.3 0.1 2.1 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 EMD59513.1 - 0.02 15.0 0.6 1.2 9.2 0.1 2.9 3 0 0 3 3 3 0 Thioesterase domain DLH PF01738.18 EMD59513.1 - 0.03 13.9 0.0 0.053 13.1 0.0 1.4 1 0 0 1 1 1 0 Dienelactone hydrolase family Ras PF00071.22 EMD59514.1 - 5.9e-42 143.0 0.0 8.4e-42 142.5 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMD59514.1 - 1.7e-29 102.5 0.0 2.4e-29 102.0 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMD59514.1 - 1.3e-10 41.0 0.0 5.9e-10 38.9 0.0 1.9 2 0 0 2 2 2 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EMD59514.1 - 0.00012 22.1 0.0 0.00018 21.5 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EMD59514.1 - 0.0023 17.5 0.0 0.022 14.3 0.0 2.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EMD59514.1 - 0.0027 17.1 0.0 0.0041 16.5 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_16 PF13191.6 EMD59514.1 - 0.0099 16.3 0.0 0.03 14.7 0.0 1.7 2 0 0 2 2 2 1 AAA ATPase domain PduV-EutP PF10662.9 EMD59514.1 - 0.011 15.5 0.0 2.2 8.0 0.0 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation ABC_tran PF00005.27 EMD59514.1 - 0.016 15.7 0.0 0.026 15.0 0.0 1.3 1 0 0 1 1 1 0 ABC transporter RsgA_GTPase PF03193.16 EMD59514.1 - 0.018 15.0 0.0 0.053 13.4 0.0 1.7 2 0 0 2 2 2 0 RsgA GTPase AAA_22 PF13401.6 EMD59514.1 - 0.029 14.6 0.1 0.17 12.2 0.1 2.2 1 1 0 1 1 1 0 AAA domain AAA_30 PF13604.6 EMD59514.1 - 0.046 13.4 0.0 0.084 12.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 EMD59514.1 - 0.068 13.1 0.0 0.15 12.0 0.0 1.6 2 0 0 2 2 2 0 NACHT domain SRPRB PF09439.10 EMD59514.1 - 0.08 12.4 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_33 PF13671.6 EMD59514.1 - 0.098 12.8 0.0 0.16 12.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EMD59514.1 - 0.12 12.2 0.0 0.47 10.2 0.0 2.0 2 0 0 2 2 2 0 P-loop containing region of AAA domain E1-E2_ATPase PF00122.20 EMD59515.1 - 3.2e-49 166.9 2.6 6.3e-49 165.9 0.3 2.3 2 0 0 2 2 2 1 E1-E2 ATPase HMA PF00403.26 EMD59515.1 - 6.5e-48 161.0 3.9 4.9e-12 46.1 0.2 4.5 4 0 0 4 4 4 4 Heavy-metal-associated domain Hydrolase PF00702.26 EMD59515.1 - 5.2e-31 108.6 1.1 1.7e-30 106.9 0.5 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EMD59515.1 - 0.0025 17.6 0.2 0.0084 15.9 0.2 1.8 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase zinc_ribbon_12 PF11331.8 EMD59515.1 - 0.056 13.3 1.3 40 4.1 0.0 3.5 3 0 0 3 3 3 0 Probable zinc-ribbon domain PCI PF01399.27 EMD59516.1 - 4.7e-07 30.3 0.0 9.4e-07 29.3 0.0 1.5 1 0 0 1 1 1 1 PCI domain CSN7a_helixI PF18392.1 EMD59516.1 - 0.064 13.2 0.2 0.11 12.4 0.2 1.4 1 0 0 1 1 1 0 COP9 signalosome complex subunit 7a helix I domain DUF5543 PF17697.1 EMD59516.1 - 0.11 12.7 0.2 0.21 11.9 0.2 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5543) MYO10_CC PF16735.5 EMD59518.1 - 0.052 13.7 0.0 0.13 12.3 0.0 1.7 1 0 0 1 1 1 0 Unconventional myosin-X coiled coil domain ANAPC1 PF12859.7 EMD59518.1 - 0.34 11.5 3.5 0.61 10.7 3.5 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 1 AAR2 PF05282.11 EMD59518.1 - 0.36 10.2 3.8 0.48 9.8 3.8 1.1 1 0 0 1 1 1 0 AAR2 protein Cutinase PF01083.22 EMD59519.1 - 1.7e-44 151.9 2.3 2.2e-44 151.6 2.3 1.1 1 0 0 1 1 1 1 Cutinase PE-PPE PF08237.11 EMD59519.1 - 9.1e-05 22.1 0.4 0.00015 21.4 0.4 1.3 1 0 0 1 1 1 1 PE-PPE domain VirJ PF06057.11 EMD59519.1 - 0.00073 19.5 0.0 0.0011 18.9 0.0 1.2 1 0 0 1 1 1 1 Bacterial virulence protein (VirJ) Lipase_3 PF01764.25 EMD59519.1 - 0.0067 16.3 0.1 0.01 15.7 0.1 1.4 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_3 PF07859.13 EMD59519.1 - 0.014 15.2 0.1 0.028 14.3 0.1 1.6 1 0 0 1 1 1 0 alpha/beta hydrolase fold DUF2974 PF11187.8 EMD59519.1 - 0.023 14.3 0.0 0.034 13.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Peptidase_M28 PF04389.17 EMD59520.1 - 2.3e-28 99.2 0.0 4.5e-28 98.3 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 EMD59520.1 - 7.5e-07 29.0 0.0 1.1e-06 28.5 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 fn3 PF00041.21 EMD59520.1 - 3.6e-05 24.0 0.4 0.00011 22.5 0.4 1.8 1 0 0 1 1 1 1 Fibronectin type III domain Peptidase_M42 PF05343.14 EMD59520.1 - 0.0045 16.1 0.0 0.0083 15.2 0.0 1.4 1 0 0 1 1 1 1 M42 glutamyl aminopeptidase MFS_1 PF07690.16 EMD59521.1 - 2.2e-13 49.9 41.5 2.2e-13 49.9 41.5 1.3 1 1 0 1 1 1 1 Major Facilitator Superfamily UNC-93 PF05978.16 EMD59521.1 - 7.3e-07 29.0 6.1 7.3e-07 29.0 6.1 2.8 2 1 0 2 2 2 1 Ion channel regulatory protein UNC-93 CN_hydrolase PF00795.22 EMD59522.1 - 1.7e-58 198.0 0.0 1.9e-58 197.9 0.0 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase GspH PF12019.8 EMD59522.1 - 0.031 14.7 0.0 5.2 7.5 0.0 2.3 2 0 0 2 2 2 0 Type II transport protein GspH HMG_box PF00505.19 EMD59523.1 - 7.9e-06 26.2 6.4 7.9e-06 26.2 6.4 2.3 2 1 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EMD59523.1 - 0.0028 18.2 1.5 0.0028 18.2 1.5 2.1 2 0 0 2 2 2 1 HMG-box domain dsrm PF00035.26 EMD59524.1 - 0.00011 22.9 0.0 0.17 12.6 0.0 3.3 3 0 0 3 3 3 2 Double-stranded RNA binding motif Dicer_dimer PF03368.14 EMD59524.1 - 0.0067 16.6 0.0 2.4 8.4 0.0 2.7 2 0 0 2 2 2 2 Dicer dimerisation domain NACHT PF05729.12 EMD59525.1 - 0.0016 18.4 0.3 0.0038 17.2 0.3 1.7 1 0 0 1 1 1 1 NACHT domain Ssl1 PF04056.14 EMD59525.1 - 0.039 13.8 0.2 0.36 10.6 0.1 2.4 1 1 1 2 2 2 0 Ssl1-like SLATT_6 PF18169.1 EMD59525.1 - 0.3 10.7 8.1 1.1 8.8 1.0 2.6 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain 6 RRM_1 PF00076.22 EMD59526.1 - 1.8e-74 245.5 4.7 1.4e-16 60.1 0.0 5.4 5 0 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EMD59526.1 - 3.3e-18 65.3 0.0 3.9e-06 26.6 0.0 5.5 5 0 0 5 5 5 4 Occluded RNA-recognition motif RRM_7 PF16367.5 EMD59526.1 - 7.3e-08 32.4 0.2 0.22 11.7 0.0 4.8 4 0 0 4 4 4 3 RNA recognition motif Nup35_RRM_2 PF14605.6 EMD59526.1 - 1.9e-06 27.8 0.2 0.0083 16.1 0.0 4.5 4 0 0 4 4 4 1 Nup53/35/40-type RNA recognition motif Limkain-b1 PF11608.8 EMD59526.1 - 2.4e-06 27.5 0.2 0.0037 17.3 0.0 4.1 4 0 0 4 4 4 1 Limkain b1 RRM_3 PF08777.11 EMD59526.1 - 4.5e-05 23.4 3.4 7.5 6.7 0.0 4.9 4 1 1 5 5 5 3 RNA binding motif RL PF17797.1 EMD59526.1 - 0.0091 15.9 0.0 0.14 12.1 0.0 2.7 2 0 0 2 2 2 1 RL domain Glyco_hyd_65N_2 PF14498.6 EMD59526.1 - 0.046 13.6 0.0 0.09 12.6 0.0 1.4 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain Dynein_light PF01221.18 EMD59527.1 - 2e-40 137.0 2.1 2.3e-40 136.8 2.1 1.1 1 0 0 1 1 1 1 Dynein light chain type 1 Peptidase_M24 PF00557.24 EMD59527.1 - 0.06 13.0 0.1 0.069 12.8 0.1 1.0 1 0 0 1 1 1 0 Metallopeptidase family M24 zinc_ribbon_15 PF17032.5 EMD59528.1 - 6.3e-06 26.8 0.4 8.8e-06 26.4 0.4 1.2 1 0 0 1 1 1 1 zinc-ribbon family zinc_ribbon_4 PF13717.6 EMD59528.1 - 0.039 13.9 0.6 0.25 11.3 0.1 2.1 2 0 0 2 2 2 0 zinc-ribbon domain zf-RING_7 PF02591.15 EMD59528.1 - 0.38 11.0 2.5 0.62 10.3 0.1 2.4 3 0 0 3 3 3 0 C4-type zinc ribbon domain HET PF06985.11 EMD59529.1 - 3.1e-25 89.2 0.0 8e-25 87.9 0.0 1.8 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Scytalone_dh PF02982.14 EMD59530.1 - 2.5e-84 280.9 0.9 2.9e-84 280.7 0.9 1.0 1 0 0 1 1 1 1 Scytalone dehydratase SnoaL_4 PF13577.6 EMD59530.1 - 3.9e-09 36.7 0.6 5.2e-09 36.3 0.6 1.1 1 0 0 1 1 1 1 SnoaL-like domain LPD23 PF18838.1 EMD59530.1 - 0.011 15.4 1.0 0.026 14.3 1.0 1.6 1 0 0 1 1 1 0 Large polyvalent protein associated domain 23 RRM_1 PF00076.22 EMD59531.1 - 4.9e-48 160.8 0.0 7.5e-17 60.9 0.0 3.1 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EMD59531.1 - 8e-08 32.2 0.2 0.0015 18.5 0.0 3.2 3 0 0 3 3 3 2 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 EMD59531.1 - 1e-05 25.5 0.0 0.0012 18.8 0.0 2.9 3 0 0 3 3 3 1 RNA binding motif RRM_occluded PF16842.5 EMD59531.1 - 0.00012 21.8 0.0 0.057 13.3 0.0 3.1 3 1 0 3 3 3 1 Occluded RNA-recognition motif RRM_7 PF16367.5 EMD59531.1 - 0.00037 20.6 0.1 0.051 13.7 0.0 2.7 3 0 0 3 3 3 1 RNA recognition motif RRM_5 PF13893.6 EMD59531.1 - 0.017 14.8 0.0 0.043 13.4 0.0 1.7 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Amidohydro_1 PF01979.20 EMD59533.1 - 8e-77 258.9 0.8 1.6e-76 257.9 0.6 1.6 2 0 0 2 2 2 1 Amidohydrolase family Urease_alpha PF00449.20 EMD59533.1 - 5.7e-56 188.0 2.3 1.2e-55 187.0 2.3 1.6 1 0 0 1 1 1 1 Urease alpha-subunit, N-terminal domain Urease_beta PF00699.20 EMD59533.1 - 2.7e-40 136.3 0.1 5.9e-40 135.3 0.1 1.6 1 0 0 1 1 1 1 Urease beta subunit Urease_gamma PF00547.18 EMD59533.1 - 3.6e-37 126.6 0.2 8.2e-37 125.5 0.2 1.7 1 0 0 1 1 1 1 Urease, gamma subunit Amidohydro_3 PF07969.11 EMD59533.1 - 9.5e-09 35.2 1.7 8e-06 25.6 0.0 2.3 1 1 0 2 2 2 2 Amidohydrolase family ADH_N_2 PF16884.5 EMD59536.1 - 1.9e-18 66.3 0.0 3.4e-18 65.5 0.0 1.4 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N PF00107.26 EMD59536.1 - 4.5e-18 65.5 0.0 7.1e-18 64.8 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EMD59536.1 - 2.2e-06 28.7 0.0 3.7e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Maf PF02545.14 EMD59537.1 - 4.7e-50 169.7 0.0 5.4e-50 169.5 0.0 1.0 1 0 0 1 1 1 1 Maf-like protein EamA PF00892.20 EMD59538.1 - 4.8e-06 26.8 34.2 0.00017 21.8 7.8 2.1 2 0 0 2 2 2 2 EamA-like transporter family PPP4R2 PF09184.11 EMD59539.1 - 2.6e-11 43.7 4.7 1.7e-10 41.0 0.0 2.6 2 1 0 2 2 2 2 PPP4R2 DUF1129 PF06570.11 EMD59541.1 - 0.018 14.5 0.7 0.018 14.5 0.7 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF1129) Phtf-FEM1B_bdg PF12129.8 EMD59541.1 - 0.16 11.8 10.1 0.053 13.3 4.4 2.3 2 0 0 2 2 2 0 Male germ-cell putative homeodomain transcription factor DUF4719 PF15843.5 EMD59541.1 - 0.21 11.7 0.1 0.39 10.8 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4719) COX8 PF02285.15 EMD59541.1 - 9 6.3 8.5 42 4.1 0.5 4.0 4 0 0 4 4 4 0 Cytochrome oxidase c subunit VIII Mpv17_PMP22 PF04117.12 EMD59542.1 - 4.1e-20 71.8 0.8 7.5e-20 70.9 0.8 1.4 1 0 0 1 1 1 1 Mpv17 / PMP22 family DUF5553 PF17707.1 EMD59544.1 - 0.014 14.8 2.4 0.025 14.0 2.4 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5553) DUF5539 PF17693.1 EMD59544.1 - 0.029 14.0 1.0 0.046 13.4 1.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5539) REV PF00424.18 EMD59544.1 - 3.4 7.7 13.2 2.7 8.1 0.6 2.4 2 0 0 2 2 2 0 REV protein (anti-repression trans-activator protein) DUF1764 PF08576.10 EMD59544.1 - 3.7 8.5 9.4 2.6 9.0 1.9 2.3 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) Presenilin PF01080.17 EMD59544.1 - 6.5 5.4 6.0 7.9 5.1 6.0 1.1 1 0 0 1 1 1 0 Presenilin BRF1 PF07741.13 EMD59544.1 - 6.8 7.1 14.3 7 7.1 2.7 2.2 2 0 0 2 2 2 0 Brf1-like TBP-binding domain Pkinase PF00069.25 EMD59545.1 - 1.1e-64 218.4 0.0 3.4e-64 216.8 0.0 1.9 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD59545.1 - 4e-36 124.6 0.0 3.1e-30 105.3 0.0 2.4 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EMD59545.1 - 6.9e-06 25.6 0.0 0.014 14.7 0.0 2.3 2 0 0 2 2 2 2 Kinase-like APH PF01636.23 EMD59545.1 - 0.0043 17.0 0.0 0.0043 17.0 0.0 1.9 2 0 0 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EMD59545.1 - 0.013 14.4 0.1 0.025 13.5 0.1 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Pkinase_fungal PF17667.1 EMD59545.1 - 0.051 12.4 0.1 0.051 12.4 0.1 3.3 3 1 0 3 3 3 0 Fungal protein kinase RIO1 PF01163.22 EMD59545.1 - 0.068 12.8 0.0 0.068 12.8 0.0 1.8 2 0 0 2 2 2 0 RIO1 family Kdo PF06293.14 EMD59545.1 - 0.073 12.4 0.0 0.14 11.4 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pyr_redox_2 PF07992.14 EMD59546.1 - 7.3e-49 166.6 1.4 9.7e-49 166.2 1.4 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Rieske PF00355.26 EMD59546.1 - 8.6e-15 54.5 0.0 1.8e-14 53.4 0.0 1.5 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Pyr_redox PF00070.27 EMD59546.1 - 1.1e-13 51.5 0.9 1.1e-13 51.5 0.9 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EMD59546.1 - 1.4e-06 27.8 0.0 0.0015 17.8 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Reductase_C PF14759.6 EMD59546.1 - 1.5e-06 28.7 0.0 7.6e-06 26.4 0.0 2.0 2 0 0 2 2 2 1 Reductase C-terminal Rieske_2 PF13806.6 EMD59546.1 - 7.3e-06 25.9 0.0 3.4e-05 23.7 0.0 2.2 2 0 0 2 2 2 1 Rieske-like [2Fe-2S] domain UDPG_MGDP_dh_N PF03721.14 EMD59546.1 - 0.028 14.0 0.5 0.16 11.6 0.2 2.2 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_binding_9 PF13454.6 EMD59546.1 - 0.036 14.1 0.0 5.4 7.0 0.0 2.5 2 0 0 2 2 2 0 FAD-NAD(P)-binding NAD_binding_7 PF13241.6 EMD59546.1 - 0.042 14.3 0.2 0.61 10.6 0.0 2.3 1 1 1 2 2 2 0 Putative NAD(P)-binding Glyco_hydro_31 PF01055.26 EMD59549.1 - 3.2e-152 507.8 5.9 4.8e-152 507.2 5.9 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.5 EMD59549.1 - 2.4e-31 108.3 0.0 4.4e-31 107.5 0.0 1.4 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Gal_mutarotas_2 PF13802.6 EMD59549.1 - 9e-06 25.9 0.7 9.3e-05 22.7 0.3 2.8 2 0 0 2 2 2 1 Galactose mutarotase-like Rotavirus_VP7 PF05868.11 EMD59549.1 - 0.16 11.3 0.1 0.69 9.2 0.0 1.9 2 0 0 2 2 2 0 Rotavirus major outer capsid protein VP7 Gly-zipper_Omp PF13488.6 EMD59550.1 - 0.014 15.4 19.7 0.014 15.4 19.7 2.3 1 1 1 2 2 2 0 Glycine zipper Sporozoite_P67 PF05642.11 EMD59550.1 - 0.07 11.2 9.3 0.086 10.9 9.3 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen TraT PF05818.12 EMD59550.1 - 0.44 10.2 3.6 0.73 9.5 3.6 1.5 1 0 0 1 1 1 0 Enterobacterial TraT complement resistance protein Gly-zipper_OmpA PF13436.6 EMD59550.1 - 1 9.2 22.9 2.3 8.1 1.1 2.4 2 0 0 2 2 2 0 Glycine-zipper domain Gly-zipper_YMGG PF13441.6 EMD59550.1 - 4.1 7.2 30.1 8.7 6.2 6.5 2.2 1 1 1 2 2 2 0 YMGG-like Gly-zipper Rick_17kDa_Anti PF05433.15 EMD59550.1 - 4.8 7.1 28.1 1.7 8.6 3.3 2.5 2 0 0 2 2 2 0 Glycine zipper 2TM domain DUF1269 PF06897.12 EMD59550.1 - 8.4 6.8 17.5 0.1 12.9 8.0 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1269) DNA_pol_lambd_f PF10391.9 EMD59551.1 - 0.089 12.6 0.0 2.3 8.1 0.0 2.3 2 0 0 2 2 2 0 Fingers domain of DNA polymerase lambda DJ-1_PfpI PF01965.24 EMD59552.1 - 4.9e-14 52.5 0.0 1e-13 51.4 0.0 1.5 1 1 0 1 1 1 1 DJ-1/PfpI family Tannase PF07519.11 EMD59553.1 - 1.4e-89 301.1 0.4 1.8e-89 300.8 0.4 1.0 1 0 0 1 1 1 1 Tannase and feruloyl esterase Peptidase_S9 PF00326.21 EMD59553.1 - 7.8e-06 25.5 0.0 0.073 12.5 0.0 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family Esterase PF00756.20 EMD59553.1 - 0.011 15.4 0.1 0.025 14.2 0.0 1.4 1 1 0 1 1 1 0 Putative esterase Hydrolase_4 PF12146.8 EMD59553.1 - 0.11 11.7 0.0 0.25 10.6 0.0 1.5 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Isochorismatase PF00857.20 EMD59554.1 - 7.9e-27 94.5 0.4 5.3e-26 91.9 0.4 1.9 1 1 0 1 1 1 1 Isochorismatase family Flexi_CP_N PF08358.10 EMD59554.1 - 0.0098 15.9 0.0 0.02 14.9 0.0 1.5 1 0 0 1 1 1 1 Carlavirus coat Zn_clus PF00172.18 EMD59555.1 - 1.8e-07 31.1 11.4 4.3e-07 29.9 11.4 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EMD59555.1 - 0.00072 18.7 0.1 0.0011 18.0 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain MFS_1 PF07690.16 EMD59556.1 - 1.8e-53 181.8 33.8 2e-52 178.3 21.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EMD59556.1 - 3e-14 52.8 21.3 1.3e-09 37.4 12.1 3.0 2 1 0 3 3 3 2 Sugar (and other) transporter TRI12 PF06609.13 EMD59556.1 - 2.5e-11 42.7 4.4 4.2e-11 42.0 4.4 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) BT1 PF03092.16 EMD59556.1 - 5.3e-05 21.7 9.8 0.033 12.4 0.2 2.2 2 0 0 2 2 2 2 BT1 family OATP PF03137.20 EMD59556.1 - 0.00029 19.3 10.8 0.00052 18.4 0.7 3.2 2 1 1 3 3 3 2 Organic Anion Transporter Polypeptide (OATP) family MFS_5 PF05631.14 EMD59556.1 - 0.0017 17.4 2.4 0.0028 16.7 0.7 2.0 2 0 0 2 2 2 1 Sugar-tranasporters, 12 TM FSH1 PF03959.13 EMD59558.1 - 1.2e-25 90.4 0.0 1.5e-25 90.2 0.0 1.1 1 0 0 1 1 1 1 Serine hydrolase (FSH1) GFO_IDH_MocA_C PF02894.17 EMD59559.1 - 3.2e-18 65.8 0.1 7.5e-18 64.6 0.1 1.6 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain GFO_IDH_MocA PF01408.22 EMD59559.1 - 1.8e-16 61.1 0.0 3.7e-16 60.0 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold NAD_binding_3 PF03447.16 EMD59559.1 - 0.067 13.8 0.0 0.11 13.2 0.0 1.4 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain Glyco_hydro_10 PF00331.20 EMD59560.1 - 8.4e-94 314.3 0.0 1e-93 314.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 10 CBM_1 PF00734.18 EMD59560.1 - 4.1e-10 39.4 3.9 1.1e-09 38.0 3.9 1.8 1 0 0 1 1 1 1 Fungal cellulose binding domain CENP-B_dimeris PF09026.10 EMD59560.1 - 3.4 8.1 7.2 22 5.5 8.1 1.7 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Aldedh PF00171.22 EMD59561.1 - 5.1e-152 506.6 0.0 6.2e-152 506.3 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 EMD59561.1 - 0.002 17.3 0.0 0.0025 16.9 0.0 1.4 1 1 0 1 1 1 1 Acyl-CoA reductase (LuxC) PAH PF02671.21 EMD59561.1 - 0.027 14.6 0.1 0.11 12.6 0.1 2.1 3 0 0 3 3 3 0 Paired amphipathic helix repeat DUF1768 PF08719.11 EMD59562.1 - 2.6e-53 180.6 0.4 2.6e-53 180.6 0.4 1.4 2 0 0 2 2 2 1 Domain of unknown function (DUF1768) DUF4360 PF14273.6 EMD59563.1 - 2e-52 177.7 0.1 2.3e-52 177.5 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4360) Ada3 PF10198.9 EMD59564.1 - 2.6e-44 150.5 0.1 2.6e-44 150.5 0.1 2.0 2 0 0 2 2 2 1 Histone acetyltransferases subunit 3 DEC-1_N PF04625.13 EMD59564.1 - 0.24 10.4 6.3 0.45 9.5 6.3 1.4 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region zf-RING_2 PF13639.6 EMD59565.1 - 1.1e-10 41.6 8.6 2.1e-10 40.7 8.6 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 EMD59565.1 - 9.6e-09 34.8 5.6 1.8e-08 34.0 5.6 1.5 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 EMD59565.1 - 1.2e-06 28.2 9.0 2.3e-06 27.4 9.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EMD59565.1 - 3.6e-06 26.8 5.3 6.5e-06 26.0 5.3 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 EMD59565.1 - 0.00012 21.9 7.1 0.00022 21.0 7.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EMD59565.1 - 0.00031 20.7 9.8 0.00087 19.3 9.8 1.9 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EMD59565.1 - 0.0017 18.2 3.9 0.0031 17.3 3.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) DUF4481 PF14800.6 EMD59565.1 - 0.0027 17.2 0.2 0.0043 16.6 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4481) zf-ANAPC11 PF12861.7 EMD59565.1 - 0.013 15.5 3.5 0.036 14.1 3.5 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 EMD59565.1 - 0.019 15.2 11.3 0.1 12.9 11.3 2.1 1 1 0 1 1 1 0 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 EMD59565.1 - 0.049 13.5 12.1 1.4 8.8 10.8 2.4 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_4 PF14570.6 EMD59565.1 - 0.089 12.6 5.1 0.18 11.6 5.1 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain DUF4577 PF15145.6 EMD59565.1 - 0.1 12.6 0.1 0.18 11.9 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4577) Na_Pi_cotrans PF02690.15 EMD59565.1 - 0.13 12.3 0.0 0.25 11.4 0.0 1.3 1 0 0 1 1 1 0 Na+/Pi-cotransporter PHD PF00628.29 EMD59565.1 - 1.7 8.6 4.5 4.3 7.3 4.5 1.7 1 0 0 1 1 1 0 PHD-finger RVT_1 PF00078.27 EMD59566.1 - 0.00013 21.6 0.2 0.00013 21.6 0.2 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) SpoIIID PF12116.8 EMD59568.1 - 0.0029 17.7 0.2 0.0035 17.4 0.2 1.2 1 1 0 1 1 1 1 Stage III sporulation protein D F-box_4 PF15966.5 EMD59568.1 - 0.059 13.3 0.0 0.07 13.0 0.0 1.1 1 0 0 1 1 1 0 F-box DNA_topoisoIV PF00521.20 EMD59568.1 - 0.061 12.2 0.9 0.064 12.1 0.9 1.0 1 0 0 1 1 1 0 DNA gyrase/topoisomerase IV, subunit A HeLo PF14479.6 EMD59571.1 - 1.4e-18 67.5 0.0 2.8e-18 66.5 0.0 1.5 1 0 0 1 1 1 1 Prion-inhibition and propagation PhdYeFM_antitox PF02604.19 EMD59574.1 - 0.061 13.1 0.1 0.076 12.8 0.1 1.2 1 0 0 1 1 1 0 Antitoxin Phd_YefM, type II toxin-antitoxin system RVT_1 PF00078.27 EMD59575.1 - 3.1e-10 39.9 2.7 3.3e-10 39.9 2.7 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) But2 PF09792.9 EMD59578.1 - 8e-32 110.6 0.2 1.1e-31 110.1 0.2 1.2 1 0 0 1 1 1 1 Ubiquitin 3 binding protein But2 C-terminal domain ABC_membrane_2 PF06472.15 EMD59579.1 - 4.3e-93 311.6 0.4 6.9e-93 310.9 0.1 1.5 2 0 0 2 2 2 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 EMD59579.1 - 3e-15 56.9 0.0 5.9e-15 56.0 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_23 PF13476.6 EMD59579.1 - 0.0054 17.3 0.8 0.29 11.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EMD59579.1 - 0.013 15.9 0.0 0.033 14.6 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain Mg_chelatase PF01078.21 EMD59579.1 - 0.027 13.9 0.0 0.045 13.1 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Rad17 PF03215.15 EMD59579.1 - 0.029 14.3 0.0 0.051 13.5 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_21 PF13304.6 EMD59579.1 - 0.03 14.1 0.0 0.065 13.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system THOC7 PF05615.13 EMD59579.1 - 0.041 14.2 1.1 0.091 13.0 1.1 1.5 1 0 0 1 1 1 0 Tho complex subunit 7 AAA PF00004.29 EMD59579.1 - 0.052 14.0 0.1 0.11 12.9 0.1 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 EMD59579.1 - 0.081 12.7 0.0 0.28 11.0 0.0 1.8 2 0 0 2 2 2 0 P-loop containing region of AAA domain Sigma54_activat PF00158.26 EMD59579.1 - 0.13 12.0 0.0 0.25 11.0 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_22 PF13401.6 EMD59579.1 - 0.14 12.4 0.0 0.36 11.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain Asp PF00026.23 EMD59580.1 - 0.00076 19.0 0.0 0.012 15.1 0.0 2.3 1 1 0 1 1 1 1 Eukaryotic aspartyl protease HLH PF00010.26 EMD59581.1 - 6.7e-12 45.2 0.1 1.1e-11 44.5 0.1 1.3 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain SLAIN PF15301.6 EMD59581.1 - 0.005 16.2 2.5 0.0077 15.5 2.5 1.3 1 0 0 1 1 1 1 SLAIN motif-containing family IGF2_C PF08365.11 EMD59581.1 - 0.24 11.5 0.0 0.24 11.5 0.0 1.9 2 0 0 2 2 2 0 Insulin-like growth factor II E-peptide NPR2 PF06218.11 EMD59582.1 - 2.7e-182 606.4 0.0 5.2e-182 605.5 0.0 1.4 1 1 0 1 1 1 1 Nitrogen permease regulator 2 NPR3 PF03666.13 EMD59582.1 - 0.1 11.3 2.9 0.14 10.9 0.0 2.6 3 1 1 4 4 4 0 Nitrogen Permease regulator of amino acid transport activity 3 tRNA-synt_2 PF00152.20 EMD59585.1 - 1.7e-57 194.9 0.0 2.2e-57 194.5 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EMD59585.1 - 2.3e-08 33.9 0.0 4.2e-08 33.1 0.0 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 EMD59585.1 - 1.2e-07 31.4 0.1 3e-05 23.6 0.0 2.6 3 0 0 3 3 3 2 tRNA synthetases class II core domain (F) HIP1_clath_bdg PF16515.5 EMD59586.1 - 0.056 14.1 0.6 0.086 13.5 0.6 1.3 1 0 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF5446 PF17522.2 EMD59586.1 - 0.11 12.7 0.2 0.36 11.0 0.1 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5446) ADH_N PF08240.12 EMD59587.1 - 1.8e-27 95.3 3.5 2.9e-27 94.7 2.6 1.8 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EMD59587.1 - 2.9e-07 30.5 0.0 0.0012 18.8 0.0 2.4 2 0 0 2 2 2 2 Zinc-binding dehydrogenase FANCL_C PF11793.8 EMD59587.1 - 0.048 13.8 1.1 0.093 12.9 1.1 1.4 1 0 0 1 1 1 0 FANCL C-terminal domain DUF4879 PF16219.5 EMD59587.1 - 0.068 13.4 0.2 0.84 9.9 0.0 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4879) ADH_N_assoc PF13823.6 EMD59587.1 - 0.11 12.5 0.1 0.11 12.5 0.1 2.0 3 0 0 3 3 3 0 Alcohol dehydrogenase GroES-associated MBOAT_2 PF13813.6 EMD59588.1 - 1.2e-13 51.1 9.5 1.2e-13 51.1 9.5 2.2 2 0 0 2 2 2 1 Membrane bound O-acyl transferase family Acyl_transf_3 PF01757.22 EMD59590.1 - 4.4e-19 68.7 24.4 5.7e-19 68.4 24.2 1.3 1 1 0 1 1 1 1 Acyltransferase family DIOX_N PF14226.6 EMD59591.1 - 0.0069 17.1 0.0 0.018 15.8 0.0 1.8 1 1 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EMD59591.1 - 0.014 15.9 0.0 0.047 14.2 0.0 1.9 2 0 0 2 2 2 0 2OG-Fe(II) oxygenase superfamily FRG1 PF06229.12 EMD59592.1 - 2.5e-52 177.4 1.4 4.6e-52 176.5 1.4 1.4 1 1 0 1 1 1 1 FRG1-like domain Fascin PF06268.13 EMD59592.1 - 0.0011 19.2 0.0 0.0073 16.5 0.0 2.4 1 1 1 2 2 2 1 Fascin domain NAD_binding_1 PF00175.21 EMD59593.1 - 6e-33 113.8 0.0 8.9e-33 113.2 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 EMD59593.1 - 9.9e-25 86.8 0.0 2.1e-24 85.7 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 EMD59593.1 - 5.6e-07 29.8 0.0 0.0024 18.0 0.0 2.3 2 0 0 2 2 2 2 Ferric reductase NAD binding domain FAD_binding_9 PF08021.11 EMD59593.1 - 0.00023 21.4 0.0 0.00071 19.8 0.0 1.7 2 0 0 2 2 2 1 Siderophore-interacting FAD-binding domain Sel1 PF08238.12 EMD59594.1 - 5.6e-38 128.5 38.2 2.2e-07 31.3 0.1 11.6 13 0 0 13 13 13 8 Sel1 repeat TPR_16 PF13432.6 EMD59594.1 - 0.012 16.2 19.1 0.11 13.1 2.3 5.5 5 0 0 5 5 5 0 Tetratricopeptide repeat OPA3 PF07047.12 EMD59594.1 - 0.068 12.9 0.1 0.15 11.8 0.1 1.5 1 0 0 1 1 1 0 Optic atrophy 3 protein (OPA3) TPR_6 PF13174.6 EMD59594.1 - 0.086 13.5 15.0 15 6.5 0.1 8.0 9 0 0 9 9 9 0 Tetratricopeptide repeat TPR_1 PF00515.28 EMD59594.1 - 0.15 12.0 0.0 0.15 12.0 0.0 6.1 6 0 0 6 6 6 0 Tetratricopeptide repeat Phage_holin_2_4 PF16082.5 EMD59594.1 - 0.15 11.8 0.7 0.49 10.2 0.7 1.9 1 0 0 1 1 1 0 Bacteriophage holin family, superfamily II-like TPR_7 PF13176.6 EMD59594.1 - 0.18 11.9 13.1 0.3 11.2 0.0 5.6 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_8 PF13181.6 EMD59594.1 - 0.24 11.7 3.4 6 7.3 0.0 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_14 PF13428.6 EMD59594.1 - 0.83 10.6 18.8 2.9 8.9 0.5 6.8 6 1 1 7 7 7 0 Tetratricopeptide repeat TPR_12 PF13424.6 EMD59594.1 - 7.1 7.0 11.5 6.3 7.2 0.8 4.6 5 0 0 5 5 5 0 Tetratricopeptide repeat MFS_1 PF07690.16 EMD59595.1 - 1.4e-38 132.7 47.0 2.2e-38 132.1 47.0 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EMD59595.1 - 1.5e-11 43.8 12.2 1.5e-11 43.8 12.2 2.3 2 0 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 EMD59595.1 - 3.2e-07 29.2 21.2 4.7e-07 28.6 21.2 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) PUCC PF03209.15 EMD59595.1 - 0.004 16.2 17.5 0.016 14.3 3.9 2.3 2 0 0 2 2 2 2 PUCC protein IBV_3C PF03620.13 EMD59595.1 - 0.05 14.1 1.4 3 8.4 0.2 2.7 2 0 0 2 2 2 0 IBV 3C protein Histidinol_dh PF00815.20 EMD59596.1 - 1.2e-159 531.8 4.9 2.1e-159 530.9 4.9 1.4 1 0 0 1 1 1 1 Histidinol dehydrogenase PRA-CH PF01502.18 EMD59596.1 - 1.5e-24 85.6 0.1 3e-24 84.7 0.1 1.5 1 0 0 1 1 1 1 Phosphoribosyl-AMP cyclohydrolase PRA-PH PF01503.17 EMD59596.1 - 1.5e-14 54.2 0.2 4.8e-14 52.6 0.2 2.0 1 0 0 1 1 1 1 Phosphoribosyl-ATP pyrophosphohydrolase Peptidase_C10 PF01640.17 EMD59596.1 - 0.097 13.0 0.0 0.2 11.9 0.0 1.5 1 0 0 1 1 1 0 Peptidase C10 family EHN PF06441.12 EMD59597.1 - 1.6e-35 121.7 0.5 2.9e-35 120.9 0.5 1.5 1 0 0 1 1 1 1 Epoxide hydrolase N terminus Abhydrolase_1 PF00561.20 EMD59597.1 - 2.9e-10 40.2 0.0 6.7e-10 39.0 0.0 1.7 1 0 0 1 1 1 1 alpha/beta hydrolase fold Tannase PF07519.11 EMD59598.1 - 2.4e-112 376.2 0.7 2.9e-112 376.0 0.7 1.1 1 0 0 1 1 1 1 Tannase and feruloyl esterase Hydrolase_4 PF12146.8 EMD59598.1 - 0.00011 21.5 0.0 0.11 11.8 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Lipocalin_5 PF13924.6 EMD59599.1 - 4.2e-31 107.6 0.0 5e-31 107.4 0.0 1.1 1 0 0 1 1 1 1 Lipocalin-like domain Sulfate_transp PF00916.20 EMD59600.1 - 7.3e-113 377.2 22.4 9.4e-113 376.8 22.4 1.1 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 EMD59600.1 - 5.7e-08 32.4 0.0 1.2e-07 31.4 0.0 1.4 1 0 0 1 1 1 1 STAS domain MFS_MOT1 PF16983.5 EMD59600.1 - 0.0016 18.8 5.1 0.0016 18.8 5.1 3.4 3 2 0 3 3 3 2 Molybdate transporter of MFS superfamily Glyco_hydro_45 PF02015.16 EMD59601.1 - 5.8e-84 281.2 16.0 6.9e-84 281.0 16.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 45 Fringe PF02434.16 EMD59602.1 - 5e-09 36.0 0.1 5.5e-08 32.6 0.1 2.1 1 1 0 1 1 1 1 Fringe-like PAN_4 PF14295.6 EMD59602.1 - 0.0018 18.1 1.0 0.0037 17.1 1.0 1.4 1 0 0 1 1 1 1 PAN domain DUF604 PF04646.12 EMD59602.1 - 0.0053 16.2 0.0 0.01 15.3 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF604 Galactosyl_T PF01762.21 EMD59602.1 - 0.019 14.8 0.0 0.15 11.9 0.1 2.1 1 1 1 2 2 2 0 Galactosyltransferase SH3_9 PF14604.6 EMD59603.1 - 1.5e-14 53.5 0.1 2.8e-14 52.7 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EMD59603.1 - 4.1e-12 45.5 0.0 8.2e-12 44.5 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SAM_2 PF07647.17 EMD59603.1 - 6.6e-11 42.2 0.0 1.1e-10 41.4 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PH PF00169.29 EMD59603.1 - 5.1e-09 36.6 0.0 2.8e-08 34.2 0.0 2.2 1 1 0 1 1 1 1 PH domain SH3_2 PF07653.17 EMD59603.1 - 2.1e-06 27.3 0.0 4e-06 26.4 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SAM_1 PF00536.30 EMD59603.1 - 0.0039 17.6 0.0 0.014 15.8 0.0 1.9 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) PH_8 PF15409.6 EMD59603.1 - 0.074 13.3 0.0 0.25 11.6 0.0 1.9 1 0 0 1 1 1 0 Pleckstrin homology domain zf-MIZ PF02891.20 EMD59604.1 - 5.8e-11 42.0 0.7 1.3e-10 40.9 0.7 1.6 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger Cut12 PF11500.8 EMD59604.1 - 0.12 12.3 2.5 0.28 11.1 2.5 1.5 1 0 0 1 1 1 0 Spindle pole body formation-associated protein zf-RanBP PF00641.18 EMD59604.1 - 4.2 6.8 5.6 4.3 6.7 0.6 2.4 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others AT_hook PF02178.19 EMD59604.1 - 4.6 7.5 10.4 0.38 10.8 2.3 2.7 2 0 0 2 2 2 0 AT hook motif SprT-like PF10263.9 EMD59605.1 - 0.00014 21.7 0.6 0.00043 20.1 0.4 1.9 2 0 0 2 2 2 1 SprT-like family Evr1_Alr PF04777.13 EMD59605.1 - 0.18 12.3 0.5 1.8 9.1 0.1 2.3 2 0 0 2 2 2 0 Erv1 / Alr family MRI PF15325.6 EMD59607.1 - 0.0098 17.0 2.4 0.013 16.6 1.1 1.9 1 1 0 1 1 1 1 Modulator of retrovirus infection Raf1_N PF18578.1 EMD59607.1 - 0.053 14.0 0.0 0.1 13.1 0.0 1.4 1 0 0 1 1 1 0 Rubisco accumulation factor 1 alpha helical domain RRM_1 PF00076.22 EMD59607.1 - 0.1 12.4 0.0 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Glyco_hydro_16 PF00722.21 EMD59608.1 - 1.5e-42 145.1 0.5 2.9e-42 144.1 0.5 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 TMIE PF16038.5 EMD59608.1 - 0.026 14.3 0.0 0.054 13.3 0.0 1.4 1 0 0 1 1 1 0 TMIE protein DUF4448 PF14610.6 EMD59608.1 - 0.066 13.0 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) Acyl-CoA_dh_1 PF00441.24 EMD59609.1 - 2.7e-37 128.3 6.4 4.2e-37 127.7 6.4 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 EMD59609.1 - 1.5e-30 106.2 0.2 3.7e-30 104.9 0.0 1.7 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 EMD59609.1 - 2.8e-24 85.1 0.0 8.7e-24 83.6 0.0 1.9 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 EMD59609.1 - 1.2e-15 57.9 2.6 1.8e-15 57.4 2.6 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain HpaB_N PF11794.8 EMD59609.1 - 0.00044 20.0 0.2 0.0015 18.3 0.0 1.8 2 1 0 2 2 2 1 4-hydroxyphenylacetate 3-hydroxylase N terminal AgrD PF05931.11 EMD59609.1 - 0.09 12.8 0.0 0.32 11.0 0.0 2.0 1 0 0 1 1 1 0 Staphylococcal AgrD protein APG6_N PF17675.1 EMD59610.1 - 1.5e-06 28.8 113.9 0.014 15.9 20.1 7.5 2 1 5 7 7 7 4 Apg6 coiled-coil region GAS PF13851.6 EMD59610.1 - 9.2e-06 25.1 93.6 0.0074 15.7 16.6 7.7 2 1 5 7 7 7 5 Growth-arrest specific micro-tubule binding ATG16 PF08614.11 EMD59610.1 - 8.1e-05 22.9 115.5 0.029 14.6 11.6 7.0 1 1 6 7 7 7 3 Autophagy protein 16 (ATG16) TPR_MLP1_2 PF07926.12 EMD59610.1 - 0.00016 21.7 109.1 0.054 13.5 8.5 7.1 3 2 2 6 6 6 4 TPR/MLP1/MLP2-like protein Filament PF00038.21 EMD59610.1 - 0.00017 21.3 81.4 0.82 9.2 10.1 5.4 2 1 2 4 4 4 2 Intermediate filament protein DUF4201 PF13870.6 EMD59610.1 - 0.00018 21.3 16.9 0.00018 21.3 16.9 6.6 2 1 4 6 6 6 1 Domain of unknown function (DUF4201) DUF3450 PF11932.8 EMD59610.1 - 0.00031 20.1 82.8 0.018 14.4 8.1 7.4 2 1 5 8 8 8 6 Protein of unknown function (DUF3450) CENP-F_leu_zip PF10473.9 EMD59610.1 - 0.00033 20.7 103.8 0.00051 20.1 19.7 6.3 2 1 3 6 6 6 3 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ADIP PF11559.8 EMD59610.1 - 0.00045 20.3 9.2 0.00045 20.3 9.2 7.7 3 1 5 8 8 8 4 Afadin- and alpha -actinin-Binding BRE1 PF08647.11 EMD59610.1 - 0.00053 20.0 13.5 0.00053 20.0 13.5 7.4 4 3 4 8 8 8 1 BRE1 E3 ubiquitin ligase TolA_bind_tri PF16331.5 EMD59610.1 - 0.008 16.2 2.3 0.008 16.2 2.3 8.1 5 2 4 9 9 9 1 TolA binding protein trimerisation Uso1_p115_C PF04871.13 EMD59610.1 - 0.0081 16.5 10.1 0.0081 16.5 10.1 7.6 2 1 4 7 7 7 1 Uso1 / p115 like vesicle tethering protein, C terminal region DMPK_coil PF08826.10 EMD59610.1 - 0.02 15.0 1.2 0.02 15.0 1.2 9.3 6 4 2 9 9 7 0 DMPK coiled coil domain like IFT57 PF10498.9 EMD59610.1 - 0.027 13.4 66.0 0.089 11.7 12.2 5.0 2 1 2 4 4 4 0 Intra-flagellar transport protein 57 DUF1664 PF07889.12 EMD59610.1 - 0.057 13.5 49.2 0.12 12.5 3.6 6.5 3 1 3 7 7 7 0 Protein of unknown function (DUF1664) Spc7 PF08317.11 EMD59610.1 - 0.081 11.8 96.9 0.04 12.8 15.7 6.1 2 1 4 6 6 6 0 Spc7 kinetochore protein MscS_porin PF12795.7 EMD59610.1 - 1.4 8.4 102.0 0.025 14.1 27.1 5.1 2 1 3 5 5 5 0 Mechanosensitive ion channel porin domain AAA_13 PF13166.6 EMD59610.1 - 2.2 6.8 68.0 0.041 12.5 27.1 3.8 2 1 2 4 4 4 0 AAA domain DUF724 PF05266.14 EMD59610.1 - 9.3 6.0 71.2 0.036 13.9 5.9 6.8 2 1 4 7 7 7 0 Protein of unknown function (DUF724) LRR_8 PF13855.6 EMD59611.1 - 6.8e-12 45.0 2.4 0.00044 20.0 0.2 4.2 2 1 4 6 6 6 4 Leucine rich repeat LRR_4 PF12799.7 EMD59611.1 - 1.2e-07 32.0 9.9 0.057 13.9 0.0 5.0 3 1 2 5 5 5 3 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EMD59611.1 - 6.5e-05 22.7 0.3 3.2 8.0 0.0 5.5 7 0 0 7 7 7 1 Leucine Rich repeat SAM_PNT PF02198.16 EMD59611.1 - 0.0011 18.8 0.0 0.0025 17.7 0.0 1.6 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain LRRNT_2 PF08263.12 EMD59611.1 - 0.0021 18.3 0.0 0.0046 17.2 0.0 1.6 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain LRR_1 PF00560.33 EMD59611.1 - 0.0025 18.1 5.2 42 5.2 0.0 6.2 7 1 0 7 7 7 0 Leucine Rich Repeat Pkinase PF00069.25 EMD59612.1 - 4e-11 42.8 0.1 2.4e-08 33.7 0.0 2.0 1 1 0 2 2 2 2 Protein kinase domain Kdo PF06293.14 EMD59612.1 - 0.031 13.7 0.0 0.041 13.2 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Methyltransf_2 PF00891.18 EMD59613.1 - 5.6e-21 74.8 0.0 1.3e-20 73.6 0.0 1.6 1 1 0 1 1 1 1 O-methyltransferase domain Pro_isomerase PF00160.21 EMD59615.1 - 1.5e-28 100.0 0.0 2.4e-28 99.4 0.0 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RRM_1 PF00076.22 EMD59615.1 - 2.1e-15 56.3 0.0 4.7e-15 55.2 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Kelch_4 PF13418.6 EMD59616.1 - 2.4e-27 94.7 9.7 7.4e-08 32.3 0.0 5.2 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_6 PF13964.6 EMD59616.1 - 7.9e-26 89.4 5.2 1.1e-07 31.9 0.5 5.0 2 1 2 4 4 4 4 Kelch motif Kelch_5 PF13854.6 EMD59616.1 - 1.9e-24 85.1 5.2 3e-06 27.1 0.0 5.0 5 0 0 5 5 5 4 Kelch motif Kelch_1 PF01344.25 EMD59616.1 - 2.5e-22 78.2 0.9 3e-06 26.7 0.1 5.3 5 0 0 5 5 5 4 Kelch motif Kelch_3 PF13415.6 EMD59616.1 - 4.9e-21 74.5 7.6 1.2e-06 28.7 0.0 6.0 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_2 PF07646.15 EMD59616.1 - 9.9e-17 60.2 2.9 6.3e-05 22.8 0.2 4.7 4 0 0 4 4 4 4 Kelch motif BTB PF00651.31 EMD59616.1 - 1.6e-08 34.7 0.0 2.9e-08 33.9 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.15 EMD59616.1 - 0.024 14.7 0.0 0.051 13.7 0.0 1.4 1 0 0 1 1 1 0 BTB And C-terminal Kelch ANAPC4_WD40 PF12894.7 EMD59617.1 - 1.3e-16 60.7 3.8 3.8e-05 23.9 0.1 4.4 3 1 1 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EMD59617.1 - 1.2e-15 57.6 11.4 0.0019 19.0 0.0 6.3 6 0 0 6 6 6 5 WD domain, G-beta repeat Ge1_WD40 PF16529.5 EMD59617.1 - 6.5e-07 28.6 0.1 0.0002 20.4 0.0 3.5 1 1 2 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 EMD59617.1 - 2e-05 24.6 1.2 0.0073 16.2 0.2 2.9 2 1 2 4 4 4 3 Eukaryotic translation initiation factor eIF2A AP1AR PF15745.5 EMD59617.1 - 0.013 15.2 1.9 0.021 14.5 1.9 1.2 1 0 0 1 1 1 0 AP-1 complex-associated regulatory protein Glyco_hyd_101C PF17451.2 EMD59617.1 - 0.029 14.6 2.1 0.96 9.7 0.2 3.1 3 0 0 3 3 3 0 Glycosyl hydrolase 101 beta sandwich domain Nucleos_tra2_C PF07662.13 EMD59618.1 - 3.1e-69 233.0 0.0 3.1e-69 233.0 0.0 2.6 2 1 0 2 2 2 1 Na+ dependent nucleoside transporter C-terminus Nucleos_tra2_N PF01773.20 EMD59618.1 - 3.9e-23 81.8 4.3 3.9e-23 81.8 4.3 3.4 3 0 0 3 3 3 1 Na+ dependent nucleoside transporter N-terminus Bromodomain PF00439.25 EMD59619.1 - 1.3e-22 79.6 1.6 2.4e-22 78.8 1.6 1.4 1 0 0 1 1 1 1 Bromodomain Acetyltransf_1 PF00583.25 EMD59619.1 - 8.1e-09 35.7 0.0 1.5e-08 34.9 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EMD59619.1 - 2.6e-07 30.6 0.2 6.3e-07 29.4 0.2 1.7 1 1 1 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EMD59619.1 - 0.00012 22.4 0.1 0.00029 21.2 0.1 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Rad1 PF02144.16 EMD59620.1 - 3.6e-87 291.9 0.1 4.2e-87 291.7 0.1 1.0 1 0 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 TFIIA PF03153.13 EMD59621.1 - 2.4e-81 274.9 34.9 7.4e-57 194.2 29.5 2.0 1 1 1 2 2 2 2 Transcription factor IIA, alpha/beta subunit Neur_chan_memb PF02932.16 EMD59621.1 - 0.89 9.6 4.2 1.2 9.2 4.2 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Presenilin PF01080.17 EMD59621.1 - 9.4 4.9 9.1 12 4.5 9.1 1.2 1 0 0 1 1 1 0 Presenilin bZIP_1 PF00170.21 EMD59622.1 - 0.00032 20.7 1.7 0.00087 19.3 1.7 1.7 1 0 0 1 1 1 1 bZIP transcription factor CheR_N PF03705.15 EMD59622.1 - 0.0085 15.8 0.0 3.4 7.5 0.0 2.7 2 0 0 2 2 2 2 CheR methyltransferase, all-alpha domain ApoLp-III PF07464.11 EMD59622.1 - 0.095 12.8 0.5 0.22 11.6 0.5 1.5 1 0 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) Glutaredoxin2_C PF04399.13 EMD59622.1 - 0.13 12.1 0.2 0.32 10.8 0.2 1.6 1 0 0 1 1 1 0 Glutaredoxin 2, C terminal domain PAF-AH_p_II PF03403.13 EMD59623.1 - 9e-50 169.3 0.0 5.6e-26 90.9 0.0 3.1 2 1 0 3 3 3 2 Platelet-activating factor acetylhydrolase, isoform II Chlorophyllase2 PF12740.7 EMD59623.1 - 1.2e-06 27.6 0.0 4.4e-05 22.5 0.0 2.2 2 0 0 2 2 2 1 Chlorophyllase enzyme Hydrolase_4 PF12146.8 EMD59623.1 - 0.00022 20.6 0.0 0.2 10.9 0.0 2.3 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Chlorophyllase PF07224.11 EMD59623.1 - 0.0012 18.0 0.0 0.0031 16.6 0.0 1.6 2 0 0 2 2 2 1 Chlorophyllase Fibrinogen_C PF00147.18 EMD59623.1 - 0.063 13.1 0.4 0.12 12.2 0.4 1.4 1 0 0 1 1 1 0 Fibrinogen beta and gamma chains, C-terminal globular domain Metallophos PF00149.28 EMD59624.1 - 4.4e-13 50.2 0.1 6.6e-13 49.6 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DUF4192 PF13830.6 EMD59625.1 - 0.2 11.7 0.0 0.25 11.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4192) Neur_chan_memb PF02932.16 EMD59625.1 - 2.8 7.9 9.2 3.6 7.6 9.2 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Thg1 PF04446.12 EMD59626.1 - 2e-50 170.0 0.1 3.1e-50 169.4 0.1 1.3 1 0 0 1 1 1 1 tRNAHis guanylyltransferase Thg1C PF14413.6 EMD59626.1 - 2.3e-47 160.1 2.7 1.3e-43 148.1 0.0 3.5 4 1 0 4 4 4 2 Thg1 C terminal domain Sugar_tr PF00083.24 EMD59630.1 - 4.5e-111 371.9 21.9 5.2e-111 371.7 21.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD59630.1 - 8.8e-27 93.9 28.4 4e-19 68.7 3.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DnaJ PF00226.31 EMD59631.1 - 6e-09 35.9 0.0 1.3e-08 34.9 0.0 1.6 1 0 0 1 1 1 1 DnaJ domain Glyco_hydro_79C PF16862.5 EMD59632.1 - 9.4e-21 74.6 0.4 2.8e-20 73.1 0.4 1.9 1 0 0 1 1 1 1 Glycosyl hydrolase family 79 C-terminal beta domain AA_permease_2 PF13520.6 EMD59633.1 - 1.7e-49 168.8 48.4 2e-49 168.6 48.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EMD59633.1 - 1.5e-23 83.1 40.1 2.1e-23 82.7 40.1 1.1 1 0 0 1 1 1 1 Amino acid permease DUF3593 PF12159.8 EMD59633.1 - 1.8 8.6 6.5 0.52 10.4 0.7 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3593) GFA PF04828.14 EMD59634.1 - 0.031 14.6 0.0 0.074 13.4 0.0 1.6 1 0 0 1 1 1 0 Glutathione-dependent formaldehyde-activating enzyme DZR PF12773.7 EMD59634.1 - 0.076 13.1 0.0 0.15 12.1 0.0 1.4 1 0 0 1 1 1 0 Double zinc ribbon FMO-like PF00743.19 EMD59635.1 - 6.9e-62 209.6 0.0 1.1e-61 208.9 0.0 1.2 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EMD59635.1 - 1.1e-22 80.7 0.1 6.7e-19 68.3 0.2 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EMD59635.1 - 3e-19 69.4 0.3 5.4e-14 52.1 0.1 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EMD59635.1 - 1.7e-08 34.0 0.3 9e-07 28.3 0.3 2.8 3 1 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 EMD59635.1 - 3.4e-07 30.4 1.1 0.00035 20.6 0.3 3.1 2 1 0 2 2 2 2 FAD-NAD(P)-binding HI0933_like PF03486.14 EMD59635.1 - 0.00033 19.5 0.1 0.4 9.3 0.0 2.3 2 0 0 2 2 2 2 HI0933-like protein NAD_binding_8 PF13450.6 EMD59635.1 - 0.0029 17.8 0.0 0.0099 16.1 0.0 1.9 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EMD59635.1 - 0.0031 17.2 0.4 0.18 11.4 0.0 2.9 2 1 0 3 3 3 1 FAD dependent oxidoreductase IlvN PF07991.12 EMD59635.1 - 0.019 14.5 0.0 0.3 10.6 0.0 2.5 3 0 0 3 3 3 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain Pyr_redox PF00070.27 EMD59635.1 - 0.1 13.2 0.5 0.59 10.7 0.1 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase MFS_1 PF07690.16 EMD59637.1 - 3.8e-37 128.0 27.9 3.8e-37 128.0 27.9 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily Cellulase PF00150.18 EMD59638.1 - 3.4e-17 62.8 3.3 1e-16 61.2 3.3 1.7 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) MFS_1 PF07690.16 EMD59639.1 - 1e-56 192.4 55.2 1.5e-44 152.4 19.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EMD59639.1 - 4.6e-09 35.3 28.6 0.00032 19.4 14.0 3.1 2 1 0 2 2 2 2 MFS/sugar transport protein MFS_1_like PF12832.7 EMD59639.1 - 8.4e-05 21.6 7.0 8.4e-05 21.6 7.0 2.9 2 1 0 2 2 2 2 MFS_1 like family OATP PF03137.20 EMD59639.1 - 0.0012 17.3 0.1 0.023 13.0 0.8 2.3 2 0 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family MFS_4 PF06779.14 EMD59639.1 - 0.035 13.4 22.5 0.11 11.8 6.3 2.6 2 1 0 2 2 2 0 Uncharacterised MFS-type transporter YbfB Chal_sti_synt_N PF00195.19 EMD59640.1 - 5.7e-26 91.3 0.0 1.2e-25 90.3 0.0 1.4 1 0 0 1 1 1 1 Chalcone and stilbene synthases, N-terminal domain Chal_sti_synt_C PF02797.15 EMD59640.1 - 7.1e-19 68.3 0.0 1.3e-18 67.4 0.0 1.5 1 0 0 1 1 1 1 Chalcone and stilbene synthases, C-terminal domain ACP_syn_III_C PF08541.10 EMD59640.1 - 3.6e-08 33.5 0.1 1.1e-06 28.7 0.0 2.8 2 1 1 3 3 3 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal FAE1_CUT1_RppA PF08392.12 EMD59640.1 - 3.5e-06 26.5 0.0 4.7e-06 26.1 0.0 1.2 1 0 0 1 1 1 1 FAE1/Type III polyketide synthase-like protein ACP_syn_III PF08545.10 EMD59640.1 - 0.0018 18.1 1.6 0.0057 16.5 1.6 1.8 1 1 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Ig_C17orf99 PF17736.1 EMD59640.1 - 0.062 13.3 0.1 0.24 11.4 0.0 2.0 2 0 0 2 2 2 0 C17orf99 Ig domain TPR_10 PF13374.6 EMD59642.1 - 2.5e-21 74.9 14.5 4.1e-07 29.7 0.0 5.9 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_12 PF13424.6 EMD59642.1 - 1.2e-17 64.0 16.4 2e-08 34.4 0.1 4.7 3 1 2 5 5 5 4 Tetratricopeptide repeat TPR_19 PF14559.6 EMD59642.1 - 1.2e-11 44.9 8.7 0.048 14.2 0.1 5.3 3 1 2 5 5 5 4 Tetratricopeptide repeat TPR_20 PF14561.6 EMD59642.1 - 2.5e-09 37.3 11.0 0.025 14.9 0.2 5.3 2 1 3 5 5 5 3 Tetratricopeptide repeat ANAPC3 PF12895.7 EMD59642.1 - 2.1e-07 31.1 2.7 0.13 12.6 0.0 4.5 1 1 3 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.6 EMD59642.1 - 4.3e-07 30.2 10.4 1.6 9.8 0.0 5.5 5 0 0 5 5 4 3 Tetratricopeptide repeat AAA_22 PF13401.6 EMD59642.1 - 5.3e-07 30.0 0.0 1.6e-06 28.4 0.0 1.8 1 0 0 1 1 1 1 AAA domain NB-ARC PF00931.22 EMD59642.1 - 4.2e-06 26.1 0.0 7.4e-06 25.3 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain TPR_8 PF13181.6 EMD59642.1 - 0.00013 21.8 0.1 2.8 8.4 0.0 4.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 EMD59642.1 - 0.00031 20.6 6.2 7.7 6.9 0.1 4.6 4 0 0 4 4 4 1 Tetratricopeptide repeat AAA_16 PF13191.6 EMD59642.1 - 0.0017 18.7 0.1 0.03 14.7 0.1 3.1 2 1 0 2 2 2 1 AAA ATPase domain TPR_16 PF13432.6 EMD59642.1 - 0.0019 18.8 13.4 0.0085 16.7 0.8 4.2 3 2 0 3 3 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 EMD59642.1 - 0.003 17.5 6.1 2.9 8.1 0.0 4.7 5 0 0 5 5 4 2 Tetratricopeptide repeat NACHT PF05729.12 EMD59642.1 - 0.0048 16.8 0.0 0.0089 16.0 0.0 1.5 1 0 0 1 1 1 1 NACHT domain TPR_6 PF13174.6 EMD59642.1 - 0.0086 16.7 4.5 24 5.8 0.1 5.1 4 0 0 4 4 4 0 Tetratricopeptide repeat Fis1_TPR_N PF14852.6 EMD59642.1 - 0.035 13.8 0.2 7.8 6.3 0.0 3.5 3 0 0 3 3 3 0 Fis1 N-terminal tetratricopeptide repeat TPR_9 PF13371.6 EMD59642.1 - 0.25 11.5 3.7 1.3 9.2 0.7 3.0 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_4 PF07721.14 EMD59642.1 - 2.2 9.2 0.0 2.2 9.2 0.0 4.3 5 0 0 5 5 3 0 Tetratricopeptide repeat AtuA PF07287.11 EMD59643.1 - 1.1e-135 451.9 1.2 1.5e-135 451.4 1.2 1.2 1 0 0 1 1 1 1 Acyclic terpene utilisation family protein AtuA DUF1048 PF06304.11 EMD59643.1 - 0.11 13.0 0.0 0.69 10.4 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1048) DUF2070 PF09843.9 EMD59644.1 - 0.026 12.8 2.1 0.032 12.5 2.1 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) zf-CCHC_6 PF15288.6 EMD59644.1 - 0.046 13.6 0.5 0.11 12.4 0.5 1.6 1 0 0 1 1 1 0 Zinc knuckle DctQ PF04290.12 EMD59644.1 - 0.069 13.1 8.6 0.075 13.0 6.0 2.2 2 1 1 3 3 3 0 Tripartite ATP-independent periplasmic transporters, DctQ component Methyltransf_23 PF13489.6 EMD59647.1 - 1.1e-19 70.8 0.0 1.5e-19 70.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMD59647.1 - 4.9e-09 36.8 0.0 1.2e-08 35.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMD59647.1 - 1.2e-07 32.3 0.0 3.3e-07 30.9 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMD59647.1 - 3.6e-06 27.7 0.0 2.4e-05 25.0 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMD59647.1 - 8.2e-05 22.4 0.0 0.00093 19.0 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EMD59647.1 - 0.013 15.1 0.0 0.023 14.3 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_4 PF02390.17 EMD59647.1 - 0.013 14.9 0.0 0.022 14.2 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase CMAS PF02353.20 EMD59647.1 - 0.055 12.7 0.0 0.096 12.0 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase PrmA PF06325.13 EMD59647.1 - 0.061 12.7 0.0 0.097 12.0 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) SBF PF01758.16 EMD59648.1 - 4.7e-52 176.5 8.1 9.9e-52 175.5 8.1 1.6 1 0 0 1 1 1 1 Sodium Bile acid symporter family PIG-P PF08510.12 EMD59648.1 - 2.8 7.9 6.5 12 5.8 0.2 3.1 2 1 1 3 3 3 0 PIG-P ZFYVE21_C PF16696.5 EMD59649.1 - 0.0015 18.4 0.1 0.002 18.0 0.1 1.2 1 0 0 1 1 1 1 Zinc finger FYVE domain-containing protein 21 C-terminus LRR19-TM PF15176.6 EMD59649.1 - 0.16 11.9 0.3 0.16 11.9 0.3 1.8 2 0 0 2 2 2 0 Leucine-rich repeat family 19 TM domain HLH PF00010.26 EMD59650.1 - 5.4e-14 51.9 0.1 1.3e-13 50.6 0.1 1.7 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain KLRAQ PF10205.9 EMD59650.1 - 0.21 11.9 1.5 1.1 9.5 0.5 2.4 1 1 1 2 2 2 0 Predicted coiled-coil domain-containing protein bZIP_2 PF07716.15 EMD59650.1 - 0.23 11.6 5.6 0.088 12.9 1.3 2.2 2 0 0 2 2 2 0 Basic region leucine zipper zf-RING_2 PF13639.6 EMD59651.1 - 4.2e-12 46.2 5.1 4.2e-12 46.2 5.1 1.8 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.25 EMD59651.1 - 3e-09 36.6 3.2 3e-09 36.6 3.2 1.5 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EMD59651.1 - 3.7e-09 36.2 3.4 9.1e-09 34.9 3.4 1.7 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 EMD59651.1 - 1e-08 34.9 4.2 1.8e-08 34.1 4.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EMD59651.1 - 1.8e-07 31.3 10.3 4.1e-07 30.2 8.0 2.4 2 1 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 EMD59651.1 - 1.2e-05 25.3 0.4 3.8e-05 23.6 0.3 1.9 1 1 1 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 EMD59651.1 - 1.3e-05 25.1 3.4 2.4e-05 24.2 3.4 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EMD59651.1 - 9.6e-05 22.2 1.4 0.00016 21.5 1.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EMD59651.1 - 0.00012 22.0 4.1 0.00023 21.1 4.1 1.5 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 EMD59651.1 - 0.0064 16.1 4.6 0.0064 16.1 4.6 1.7 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type RINGv PF12906.7 EMD59651.1 - 0.0073 16.4 6.8 0.028 14.5 3.8 2.3 1 1 1 2 2 2 1 RING-variant domain Prok-RING_4 PF14447.6 EMD59651.1 - 0.0095 15.8 4.2 0.0095 15.8 4.2 1.8 2 1 0 2 2 1 1 Prokaryotic RING finger family 4 FANCL_C PF11793.8 EMD59651.1 - 0.01 16.0 10.4 0.11 12.7 7.3 2.9 1 1 0 2 2 2 0 FANCL C-terminal domain TMEM154 PF15102.6 EMD59651.1 - 0.014 15.3 0.2 0.021 14.7 0.2 1.3 1 0 0 1 1 1 0 TMEM154 protein family DUF3377 PF11857.8 EMD59651.1 - 0.053 13.5 0.3 0.12 12.3 0.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) Zf_RING PF16744.5 EMD59651.1 - 0.066 13.3 1.9 0.14 12.3 1.9 1.6 1 0 0 1 1 1 0 KIAA1045 RING finger zf-C3HC4_4 PF15227.6 EMD59651.1 - 0.14 12.3 4.9 0.1 12.8 3.0 1.8 2 1 0 2 2 1 0 zinc finger of C3HC4-type, RING PHD PF00628.29 EMD59651.1 - 0.22 11.4 4.9 0.43 10.5 4.9 1.5 1 0 0 1 1 1 0 PHD-finger zf_Rg PF17915.1 EMD59651.1 - 0.28 10.6 1.6 5.5 6.5 0.3 2.2 2 0 0 2 2 2 0 Reverse gyrase zinc finger zf-RING_4 PF14570.6 EMD59651.1 - 0.39 10.6 4.6 0.73 9.7 4.6 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING-like PF08746.11 EMD59651.1 - 0.54 10.6 8.0 0.27 11.6 5.6 1.8 2 1 0 2 2 2 0 RING-like domain TFB6 PF17110.5 EMD59653.1 - 8.4e-56 188.4 0.1 1e-55 188.1 0.1 1.1 1 0 0 1 1 1 1 Subunit 11 of the general transcription factor TFIIH Bul1_N PF04425.12 EMD59654.1 - 7.2e-07 28.3 0.6 4.2e-06 25.8 0.1 2.1 1 1 1 2 2 2 1 Bul1 N terminus Bul1_C PF04426.12 EMD59654.1 - 6.9e-06 25.7 0.1 1.3e-05 24.8 0.1 1.4 1 0 0 1 1 1 1 Bul1 C terminus Arrestin_N PF00339.29 EMD59654.1 - 7.2e-05 22.9 0.0 0.00014 21.9 0.0 1.5 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Tmemb_14 PF03647.13 EMD59655.1 - 2.4e-24 85.9 3.7 2.8e-24 85.7 3.7 1.0 1 0 0 1 1 1 1 Transmembrane proteins 14C Phage_holin_2_4 PF16082.5 EMD59655.1 - 0.2 11.4 3.6 0.25 11.1 0.5 2.4 1 1 2 3 3 3 0 Bacteriophage holin family, superfamily II-like Gram_pos_anchor PF00746.21 EMD59655.1 - 0.21 11.5 0.1 0.21 11.5 0.1 3.1 4 0 0 4 4 4 0 LPXTG cell wall anchor motif p450 PF00067.22 EMD59656.1 - 1.8e-33 116.0 0.0 2.4e-33 115.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 EMD59657.1 - 8.4e-26 90.7 0.1 7.2e-16 58.0 0.1 2.3 1 1 0 2 2 2 2 Cytochrome P450 HATPase_c PF02518.26 EMD59658.1 - 2e-23 83.0 0.0 3.7e-23 82.2 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EMD59658.1 - 1.7e-19 70.0 0.0 6.1e-19 68.3 0.0 2.0 1 1 0 1 1 1 1 Response regulator receiver domain PAS_4 PF08448.10 EMD59658.1 - 2e-09 37.7 0.0 1.2e-07 31.9 0.0 3.0 3 0 0 3 3 3 1 PAS fold HisKA PF00512.25 EMD59658.1 - 1.4e-06 28.3 0.6 4.6e-06 26.6 0.0 2.3 2 1 0 2 2 2 1 His Kinase A (phospho-acceptor) domain PAS_8 PF13188.7 EMD59658.1 - 2e-06 27.7 0.0 5.4e-06 26.3 0.0 1.8 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 EMD59658.1 - 1.6e-05 24.9 0.0 0.00061 19.8 0.0 2.7 2 0 0 2 2 2 1 PAS fold PAS_9 PF13426.7 EMD59658.1 - 5.8e-05 23.3 0.0 0.0011 19.1 0.0 2.8 2 1 1 3 3 3 1 PAS domain PAS_3 PF08447.12 EMD59658.1 - 8.8e-05 22.7 0.1 0.00022 21.4 0.1 1.8 1 0 0 1 1 1 1 PAS fold GAF_2 PF13185.6 EMD59658.1 - 0.022 15.0 0.0 0.18 12.1 0.0 2.3 1 1 1 2 2 2 0 GAF domain Glyco_hydro_52 PF03512.13 EMD59658.1 - 0.13 11.2 0.0 0.64 8.9 0.0 1.9 2 0 0 2 2 2 0 Glycosyl hydrolase family 52 WW PF00397.26 EMD59659.1 - 3.1e-10 39.9 5.3 6.5e-10 38.9 5.3 1.6 1 0 0 1 1 1 1 WW domain UDG PF03167.19 EMD59660.1 - 1.8e-17 63.8 0.0 5.2e-17 62.3 0.0 1.7 1 1 1 2 2 2 1 Uracil DNA glycosylase superfamily DIT1_PvcA PF05141.12 EMD59663.1 - 2.7e-84 282.9 0.0 3.3e-84 282.6 0.0 1.1 1 0 0 1 1 1 1 Pyoverdine/dityrosine biosynthesis protein HATPase_c PF02518.26 EMD59664.1 - 1.5e-22 80.2 0.0 6.6e-21 74.9 0.0 2.4 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EMD59664.1 - 3.7e-22 78.6 1.2 9.3e-22 77.3 1.2 1.7 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 EMD59664.1 - 1.7e-09 37.5 0.1 5.6e-09 35.9 0.1 1.9 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain PAS_4 PF08448.10 EMD59664.1 - 9.4e-09 35.5 0.0 9.3e-07 29.1 0.0 2.7 2 0 0 2 2 2 1 PAS fold PAS PF00989.25 EMD59664.1 - 3.3e-06 27.1 0.0 7.5e-06 25.9 0.0 1.6 1 0 0 1 1 1 1 PAS fold PAS_8 PF13188.7 EMD59664.1 - 0.005 16.8 0.0 0.013 15.5 0.0 1.7 1 0 0 1 1 1 1 PAS domain GAF_2 PF13185.6 EMD59664.1 - 0.013 15.8 0.0 0.044 14.1 0.0 1.9 2 0 0 2 2 2 0 GAF domain PAS_9 PF13426.7 EMD59664.1 - 0.028 14.7 0.0 0.074 13.3 0.0 1.8 1 0 0 1 1 1 0 PAS domain DUF1828 PF08861.10 EMD59664.1 - 0.031 14.6 0.0 0.081 13.2 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function DUF1828 GAF PF01590.26 EMD59664.1 - 0.16 12.6 0.0 0.35 11.5 0.0 1.6 1 0 0 1 1 1 0 GAF domain F-box PF00646.33 EMD59665.1 - 4.5e-12 45.5 0.3 1.8e-11 43.6 0.3 2.1 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EMD59665.1 - 1.8e-08 34.1 0.2 3.9e-08 33.1 0.2 1.6 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.7 EMD59665.1 - 1.9e-06 28.1 5.9 0.031 14.7 0.0 5.7 5 2 2 7 7 7 1 Leucine Rich repeats (2 copies) TPR_2 PF07719.17 EMD59665.1 - 3e-06 26.9 2.5 0.00073 19.5 0.2 2.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 EMD59665.1 - 1.8e-05 24.3 1.0 0.0038 17.0 0.1 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 EMD59665.1 - 0.002 18.4 0.4 0.011 16.0 0.2 2.2 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 EMD59665.1 - 0.018 15.7 0.6 1.1 10.1 0.1 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat LRR_8 PF13855.6 EMD59665.1 - 0.051 13.3 0.8 4.1 7.2 0.0 4.0 4 0 0 4 4 4 0 Leucine rich repeat TPR_8 PF13181.6 EMD59665.1 - 0.058 13.6 1.2 0.46 10.8 0.1 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.6 EMD59665.1 - 0.13 12.2 0.2 19 5.3 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 EMD59665.1 - 0.16 12.1 0.5 7.6 6.8 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat RNA_pol_Rpb2_6 PF00562.28 EMD59666.1 - 1.2e-123 413.1 0.1 1.8e-123 412.5 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 EMD59666.1 - 2.9e-60 203.3 0.0 5e-60 202.5 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.14 EMD59666.1 - 1.5e-41 142.1 0.8 3e-41 141.2 0.1 1.9 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.20 EMD59666.1 - 4.2e-32 110.4 0.0 8.4e-32 109.4 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_3 PF04565.16 EMD59666.1 - 1.3e-25 89.3 0.1 3.1e-25 88.1 0.1 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_4 PF04566.13 EMD59666.1 - 6e-22 77.7 0.3 1.3e-21 76.6 0.3 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_5 PF04567.17 EMD59666.1 - 1.7e-21 76.5 0.1 5e-21 75.0 0.1 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 ubiquitin PF00240.23 EMD59667.1 - 1.2e-19 69.9 0.0 2e-19 69.1 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family UBA PF00627.31 EMD59667.1 - 6.5e-09 35.5 0.1 6.5e-09 35.5 0.1 1.9 2 0 0 2 2 2 1 UBA/TS-N domain Rad60-SLD PF11976.8 EMD59667.1 - 1.3e-05 24.9 0.0 2.2e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 EMD59667.1 - 3.5e-05 24.3 0.0 6.6e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.6 EMD59667.1 - 0.00032 20.8 0.1 0.00056 20.0 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like HOIP-UBA PF16678.5 EMD59667.1 - 0.025 14.6 0.1 0.13 12.3 0.0 2.0 2 0 0 2 2 2 0 HOIP UBA domain pair STI1 PF17830.1 EMD59667.1 - 0.035 14.0 29.0 0.4 10.7 5.9 3.6 3 0 0 3 3 3 0 STI1 domain Blt1 PF12754.7 EMD59667.1 - 0.051 13.9 0.2 0.089 13.1 0.2 1.4 1 0 0 1 1 1 0 Blt1 N-terminal domain ADH_zinc_N PF00107.26 EMD59668.1 - 4e-31 107.7 0.1 7.8e-31 106.7 0.1 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EMD59668.1 - 1.8e-09 38.8 0.0 2.9e-09 38.1 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EMD59668.1 - 4.7e-05 23.2 0.0 0.00013 21.8 0.0 1.8 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain TrkA_N PF02254.18 EMD59668.1 - 0.0066 16.7 0.0 0.011 16.0 0.0 1.3 1 0 0 1 1 1 1 TrkA-N domain AlaDh_PNT_C PF01262.21 EMD59668.1 - 0.0094 15.3 0.2 0.015 14.6 0.2 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Molydop_binding PF01568.21 EMD59668.1 - 0.19 11.8 0.1 0.4 10.7 0.1 1.5 1 0 0 1 1 1 0 Molydopterin dinucleotide binding domain adh_short PF00106.25 EMD59669.1 - 4e-25 88.4 0.0 1.1e-19 70.7 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EMD59669.1 - 3.9e-18 65.9 0.0 1e-10 41.6 0.0 2.1 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase NAD_binding_4 PF07993.12 EMD59669.1 - 1.2e-05 24.6 0.0 1.7e-05 24.1 0.0 1.1 1 0 0 1 1 1 1 Male sterility protein Epimerase PF01370.21 EMD59669.1 - 0.00036 20.1 0.0 0.0014 18.1 0.0 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family KR PF08659.10 EMD59669.1 - 0.00063 19.7 0.0 0.0011 18.9 0.0 1.3 1 0 0 1 1 1 1 KR domain Glyoxalase PF00903.25 EMD59670.1 - 7.3e-09 35.9 0.7 4.4e-07 30.1 0.4 2.4 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 EMD59670.1 - 0.0034 17.7 0.4 2.3 8.5 0.1 2.8 2 2 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily S1-P1_nuclease PF02265.16 EMD59671.1 - 1.7e-60 205.0 0.1 1.9e-60 204.8 0.1 1.0 1 0 0 1 1 1 1 S1/P1 Nuclease A_deaminase PF00962.22 EMD59672.1 - 3e-23 82.7 0.0 4.1e-23 82.2 0.0 1.2 1 0 0 1 1 1 1 Adenosine/AMP deaminase ATG2_CAD PF13329.6 EMD59673.1 - 1.1e-43 148.7 0.0 2.4e-43 147.5 0.0 1.7 1 0 0 1 1 1 1 Autophagy-related protein 2 CAD motif ATG_C PF09333.11 EMD59673.1 - 8.3e-28 96.6 0.2 3.5e-27 94.6 0.0 2.1 2 0 0 2 2 2 1 Autophagy-related protein C terminal domain MFS_1 PF07690.16 EMD59674.1 - 2.3e-38 132.0 30.5 3.4e-38 131.5 30.5 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF1772 PF08592.11 EMD59674.1 - 2.7e-06 27.7 1.3 0.016 15.5 0.0 3.5 3 0 0 3 3 3 2 Domain of unknown function (DUF1772) UQ_con PF00179.26 EMD59677.1 - 2.1e-49 166.8 0.1 2.4e-49 166.6 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.13 EMD59677.1 - 0.014 15.2 0.1 0.021 14.7 0.1 1.4 1 1 0 1 1 1 0 UEV domain Prok-E2_B PF14461.6 EMD59677.1 - 0.047 13.4 0.0 0.069 12.9 0.0 1.3 1 0 0 1 1 1 0 Prokaryotic E2 family B RWD PF05773.22 EMD59677.1 - 0.076 13.3 0.2 0.098 13.0 0.1 1.4 1 1 0 1 1 1 0 RWD domain DUF2237 PF09996.9 EMD59680.1 - 8.7e-40 135.3 0.0 1.1e-39 135.0 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2237) DUF155 PF02582.14 EMD59681.1 - 1.1e-54 185.1 0.2 2.7e-54 183.9 0.0 1.7 2 0 0 2 2 2 1 Uncharacterised ACR, YagE family COG1723 RGS PF00615.19 EMD59682.1 - 1.2e-13 51.3 0.0 2e-10 40.9 0.0 2.3 2 0 0 2 2 2 2 Regulator of G protein signaling domain TssO PF17561.2 EMD59682.1 - 8.6 6.5 6.2 15 5.7 1.2 2.3 2 0 0 2 2 2 0 Type VI secretion system, TssO 2OG-FeII_Oxy_3 PF13640.6 EMD59683.1 - 3.5e-10 40.6 0.1 5.5e-10 40.0 0.1 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily RNA_pol_Rpb1_1 PF04997.12 EMD59684.1 - 5.6e-103 344.5 0.0 1.9e-102 342.8 0.0 1.8 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_5 PF04998.17 EMD59684.1 - 6.6e-103 343.8 0.0 1e-102 343.1 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 EMD59684.1 - 5.7e-76 254.4 0.1 1e-75 253.5 0.1 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_6 PF04992.14 EMD59684.1 - 7.9e-59 198.7 0.4 1.7e-58 197.6 0.4 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 6 RNA_pol_Rpb1_3 PF04983.18 EMD59684.1 - 2.6e-49 167.2 0.0 5.5e-49 166.1 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_7 PF04990.12 EMD59684.1 - 5.4e-43 146.2 7.0 1e-42 145.3 7.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 7 RNA_pol_Rpb1_4 PF05000.17 EMD59684.1 - 5.6e-33 113.1 0.0 1.4e-32 111.8 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_R PF05001.13 EMD59684.1 - 1e-20 72.9 195.4 0.0069 16.7 11.3 14.5 8 3 7 16 16 16 14 RNA polymerase Rpb1 C-terminal repeat WD40 PF00400.32 EMD59685.1 - 4e-14 52.8 8.9 0.00024 21.8 0.2 5.0 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD59685.1 - 1e-10 41.8 2.5 0.0098 16.2 0.0 4.7 2 2 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EMD59685.1 - 0.0042 17.0 0.1 4.1 7.2 0.0 3.1 3 0 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.16 EMD59685.1 - 0.023 13.2 0.4 1.5 7.2 0.0 2.7 1 1 0 2 2 2 0 Cytochrome D1 heme domain INO80_Ies4 PF08193.11 EMD59686.1 - 1.1e-42 146.8 15.6 1.3e-42 146.5 15.6 1.2 1 0 0 1 1 1 1 INO80 complex subunit Ies4 RBR PF17208.3 EMD59686.1 - 0.017 15.8 4.7 0.017 15.8 4.7 3.0 1 1 1 2 2 2 0 RNA binding Region Ndc1_Nup PF09531.10 EMD59686.1 - 2 7.0 3.0 2.3 6.8 3.0 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup CLTH PF10607.9 EMD59687.1 - 3.3e-34 117.9 0.0 6.9e-34 116.9 0.0 1.5 2 0 0 2 2 2 1 CTLH/CRA C-terminal to LisH motif domain SPRY PF00622.28 EMD59687.1 - 1.6e-23 83.0 0.2 2.8e-23 82.3 0.2 1.4 1 0 0 1 1 1 1 SPRY domain LisH PF08513.11 EMD59687.1 - 0.017 15.1 0.2 0.053 13.5 0.0 2.0 2 0 0 2 2 2 0 LisH PP2C PF00481.21 EMD59688.1 - 2.1e-31 109.5 0.0 7e-31 107.8 0.0 1.8 2 1 0 2 2 2 1 Protein phosphatase 2C SpoIIE PF07228.12 EMD59688.1 - 0.021 14.7 0.0 2 8.3 0.0 2.4 2 0 0 2 2 2 0 Stage II sporulation protein E (SpoIIE) Esterase_phd PF10503.9 EMD59690.1 - 9.2e-17 61.3 0.7 1.1e-16 61.0 0.7 1.1 1 0 0 1 1 1 1 Esterase PHB depolymerase Peptidase_S9 PF00326.21 EMD59690.1 - 0.00034 20.2 0.3 0.00084 18.9 0.2 1.8 2 0 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_3 PF07859.13 EMD59690.1 - 0.0019 18.1 0.1 0.0023 17.8 0.1 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_1 PF00561.20 EMD59690.1 - 0.0024 17.6 0.6 0.0034 17.1 0.6 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold BAAT_C PF08840.11 EMD59690.1 - 0.0052 16.7 0.3 0.0083 16.1 0.3 1.3 1 0 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal Eno-Rase_NADH_b PF12242.8 EMD59690.1 - 0.0057 16.4 0.1 0.013 15.3 0.1 1.6 1 0 0 1 1 1 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Abhydrolase_2 PF02230.16 EMD59690.1 - 0.018 14.9 0.1 0.31 10.8 0.0 2.2 1 1 0 2 2 2 0 Phospholipase/Carboxylesterase Esterase PF00756.20 EMD59690.1 - 0.035 13.8 0.3 0.05 13.2 0.3 1.2 1 0 0 1 1 1 0 Putative esterase ArsB PF02040.15 EMD59692.1 - 2.7e-14 53.4 16.9 1.3e-10 41.2 4.0 2.1 2 0 0 2 2 2 2 Arsenical pump membrane protein API5 PF05918.11 EMD59693.1 - 2.7 6.7 19.1 3.4 6.4 19.1 1.0 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) DUF4228 PF14009.6 EMD59693.1 - 7.1 7.0 16.5 8.9 6.7 16.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) Response_reg PF00072.24 EMD59694.1 - 2e-25 89.1 0.1 3.6e-25 88.3 0.1 1.5 1 0 0 1 1 1 1 Response regulator receiver domain HATPase_c PF02518.26 EMD59694.1 - 9.1e-23 80.9 0.0 1.8e-21 76.7 0.0 2.6 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 EMD59694.1 - 4.7e-14 52.2 0.0 1.3e-13 50.7 0.0 1.8 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HAMP PF00672.25 EMD59694.1 - 0.0031 17.9 0.7 1.4 9.4 0.1 3.6 4 0 0 4 4 4 1 HAMP domain Spectrin PF00435.21 EMD59694.1 - 2.8 8.5 5.6 12 6.4 1.6 2.4 2 0 0 2 2 2 0 Spectrin repeat SNF2_N PF00176.23 EMD59695.1 - 4.5e-65 219.7 0.4 6.7e-65 219.1 0.4 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EMD59695.1 - 1.3e-13 51.2 0.0 2.7e-13 50.2 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EMD59695.1 - 9.5e-10 38.7 0.0 2.2e-09 37.6 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit zf-C3HC4_3 PF13920.6 EMD59695.1 - 1.1e-08 34.8 3.7 3.3e-08 33.2 3.7 1.9 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMD59695.1 - 1.3e-06 28.2 6.7 3.4e-06 26.8 6.7 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EMD59695.1 - 2.1e-06 27.6 7.4 6e-06 26.2 7.4 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EMD59695.1 - 2.5e-06 27.2 1.9 2.5e-06 27.2 1.9 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EMD59695.1 - 3.1e-06 27.4 6.2 8.9e-06 26.0 6.2 1.9 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 EMD59695.1 - 6.3e-05 22.8 3.9 0.00026 20.9 4.1 2.0 1 1 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 EMD59695.1 - 0.0022 18.1 6.2 0.0065 16.6 6.3 1.9 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 EMD59695.1 - 0.0036 17.1 8.7 0.033 14.1 8.8 2.5 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 AAA_34 PF13872.6 EMD59695.1 - 0.014 14.3 0.0 0.028 13.3 0.0 1.4 1 0 0 1 1 1 0 P-loop containing NTP hydrolase pore-1 DEAD_2 PF06733.15 EMD59695.1 - 0.056 13.1 0.0 3.3 7.3 0.0 2.4 2 0 0 2 2 2 0 DEAD_2 Baculo_IE-1 PF05290.11 EMD59695.1 - 0.093 12.7 0.1 0.27 11.2 0.1 1.8 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) SPT6_acidic PF14632.6 EMD59695.1 - 0.17 12.5 19.2 0.073 13.7 15.2 2.7 2 1 0 2 2 1 0 Acidic N-terminal SPT6 YL1 PF05764.13 EMD59695.1 - 1.1 9.3 17.3 0.32 11.1 13.1 2.1 2 0 0 2 2 2 0 YL1 nuclear protein zf-RING_4 PF14570.6 EMD59695.1 - 3 7.7 5.2 18 5.3 5.5 2.2 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain FYVE PF01363.21 EMD59695.1 - 3.8 7.7 6.0 6.8 6.9 1.2 2.6 1 1 1 2 2 2 0 FYVE zinc finger HAMP PF00672.25 EMD59696.1 - 3.9e-34 116.8 23.7 3.3e-07 30.6 0.5 7.7 6 2 1 7 7 7 5 HAMP domain HATPase_c PF02518.26 EMD59696.1 - 7.3e-30 103.8 0.1 3.4e-29 101.6 0.1 2.2 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EMD59696.1 - 2.7e-28 98.4 0.3 2.3e-27 95.4 0.1 2.6 2 1 0 2 2 2 1 Response regulator receiver domain HisKA PF00512.25 EMD59696.1 - 2.3e-16 59.6 0.5 2.3e-16 59.6 0.5 3.9 4 0 0 4 4 4 1 His Kinase A (phospho-acceptor) domain Syntaxin_2 PF14523.6 EMD59696.1 - 3.9e-08 33.6 10.9 1.2 9.5 0.1 7.2 4 2 3 7 7 7 3 Syntaxin-like protein DUF4279 PF14106.6 EMD59696.1 - 8.3e-06 26.0 0.5 4.7 7.4 0.0 5.8 6 0 0 6 6 6 1 Domain of unknown function (DUF4279) DUF948 PF06103.11 EMD59696.1 - 0.0039 17.4 50.5 0.015 15.6 1.0 9.8 4 2 3 7 7 7 2 Bacterial protein of unknown function (DUF948) Cbl_N PF02262.16 EMD59696.1 - 0.036 14.1 0.0 15 5.6 0.0 3.2 2 0 0 2 2 2 0 CBL proto-oncogene N-terminal domain 1 DUF3829 PF12889.7 EMD59696.1 - 0.065 12.7 8.4 7.5 5.9 0.0 4.5 3 2 2 5 5 5 0 Protein of unknown function (DUF3829) AdHead_fibreRBD PF16812.5 EMD59696.1 - 0.089 12.6 0.1 0.28 11.0 0.1 1.8 1 0 0 1 1 1 0 C-terminal head domain of the fowl adenovirus type 1 long fibre REF PF05755.12 EMD59696.1 - 0.18 11.6 11.2 5.9 6.6 0.3 5.1 2 2 4 6 6 6 0 Rubber elongation factor protein (REF) SpoIIID PF12116.8 EMD59696.1 - 0.64 10.1 3.1 16 5.7 0.1 4.2 4 0 0 4 4 3 0 Stage III sporulation protein D HSBP1 PF06825.12 EMD59696.1 - 0.84 9.5 5.7 1 9.3 0.4 4.0 3 0 0 3 3 2 0 Heat shock factor binding protein 1 DUF4763 PF15960.5 EMD59696.1 - 1.7 7.9 6.1 20 4.4 0.0 4.3 5 0 0 5 5 5 0 Domain of unknown function (DUF4763) ApoLp-III PF07464.11 EMD59696.1 - 5.3 7.1 30.7 0.19 11.8 2.6 6.0 3 2 2 5 5 5 0 Apolipophorin-III precursor (apoLp-III) DUF2877 PF11392.8 EMD59696.1 - 5.4 7.8 6.8 13 6.5 0.4 4.0 2 1 2 4 4 3 0 Protein of unknown function (DUF2877) CMD PF02627.20 EMD59696.1 - 5.9 7.0 7.0 43 4.2 0.0 4.8 6 0 0 6 6 6 0 Carboxymuconolactone decarboxylase family DUF883 PF05957.13 EMD59696.1 - 8.8 7.0 17.3 8.6 7.0 0.5 6.0 3 1 0 6 6 6 0 Bacterial protein of unknown function (DUF883) DUF5102 PF17104.5 EMD59697.1 - 1.7e-103 346.6 2.5 1.7e-103 346.6 2.5 2.2 1 1 1 2 2 2 1 Domain of unknown function (DUF5102) Caskin-Pro-rich PF16907.5 EMD59697.1 - 0.01 16.3 0.9 0.01 16.3 0.9 2.2 2 0 0 2 2 2 0 Proline rich region of Caskin proteins DUF4543 PF15076.6 EMD59697.1 - 0.063 13.4 0.1 0.14 12.3 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4543) Nsp1_C PF05064.13 EMD59698.1 - 7.9e-34 115.9 6.7 7.9e-34 115.9 6.7 2.6 2 1 0 2 2 2 1 Nsp1-like C-terminal region BRE1 PF08647.11 EMD59698.1 - 1.9e-05 24.6 16.2 0.0048 16.9 4.1 2.4 2 1 0 2 2 2 2 BRE1 E3 ubiquitin ligase AAA_13 PF13166.6 EMD59698.1 - 0.0015 17.2 3.5 0.0015 17.2 3.5 2.0 1 1 1 2 2 2 1 AAA domain hDGE_amylase PF14701.6 EMD59698.1 - 0.002 17.3 6.8 0.004 16.3 6.8 1.4 1 1 0 1 1 1 1 Glycogen debranching enzyme, glucanotransferase domain OmpH PF03938.14 EMD59698.1 - 0.0026 18.1 18.6 0.1 12.9 6.3 2.2 2 0 0 2 2 2 2 Outer membrane protein (OmpH-like) DUF4200 PF13863.6 EMD59698.1 - 0.0054 17.1 16.9 0.14 12.5 2.4 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF4200) Laminin_II PF06009.12 EMD59698.1 - 0.0062 16.5 12.6 0.17 11.9 3.1 3.0 1 1 2 3 3 3 2 Laminin Domain II WXG100 PF06013.12 EMD59698.1 - 0.012 15.8 14.7 0.15 12.3 0.5 4.0 3 1 0 3 3 3 0 Proteins of 100 residues with WXG Taxilin PF09728.9 EMD59698.1 - 0.013 14.7 0.5 0.013 14.7 0.5 2.7 2 1 0 3 3 3 0 Myosin-like coiled-coil protein BLOC1_2 PF10046.9 EMD59698.1 - 0.015 15.6 12.8 0.29 11.5 3.4 2.6 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF2935 PF11155.8 EMD59698.1 - 0.021 15.2 0.2 0.24 11.7 0.2 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF2935) Peptidase_S64 PF08192.11 EMD59698.1 - 0.025 13.1 3.5 0.029 12.9 3.5 1.1 1 0 0 1 1 1 0 Peptidase family S64 ING PF12998.7 EMD59698.1 - 0.033 14.8 9.4 0.19 12.3 1.2 3.0 1 1 2 3 3 3 0 Inhibitor of growth proteins N-terminal histone-binding FliJ PF02050.16 EMD59698.1 - 0.043 14.0 1.2 0.043 14.0 1.2 3.4 3 1 0 3 3 3 0 Flagellar FliJ protein ERM PF00769.19 EMD59698.1 - 0.05 13.4 20.7 0.17 11.7 20.7 1.7 1 1 0 1 1 1 0 Ezrin/radixin/moesin family DUF3450 PF11932.8 EMD59698.1 - 0.052 12.8 19.3 0.041 13.2 3.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) DUF1664 PF07889.12 EMD59698.1 - 0.053 13.6 9.4 0.64 10.1 1.8 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DUF4201 PF13870.6 EMD59698.1 - 0.09 12.5 12.7 0.14 11.9 3.0 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4201) MIS13 PF08202.11 EMD59698.1 - 0.12 11.6 11.3 0.16 11.2 11.3 1.2 1 0 0 1 1 1 0 Mis12-Mtw1 protein family DUF1593 PF07632.11 EMD59698.1 - 0.13 11.7 1.7 0.15 11.5 1.2 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1593) DUF5446 PF17522.2 EMD59698.1 - 0.18 12.0 5.9 1.1 9.5 0.2 2.8 3 0 0 3 3 2 0 Family of unknown function (DUF5446) FH2 PF02181.23 EMD59698.1 - 0.21 10.7 7.3 2.2 7.3 2.0 2.2 2 0 0 2 2 2 0 Formin Homology 2 Domain V_ATPase_I PF01496.19 EMD59698.1 - 0.25 9.2 6.5 0.33 8.8 6.5 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF948 PF06103.11 EMD59698.1 - 0.27 11.5 6.8 0.36 11.1 1.3 2.9 2 2 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Tho2 PF11262.8 EMD59698.1 - 0.36 10.0 9.9 0.074 12.2 3.5 2.2 1 1 1 2 2 2 0 Transcription factor/nuclear export subunit protein 2 YtxH PF12732.7 EMD59698.1 - 0.38 11.3 3.7 0.83 10.2 0.1 2.9 2 2 0 2 2 2 0 YtxH-like protein TPD52 PF04201.15 EMD59698.1 - 0.41 10.2 9.4 0.42 10.2 1.2 2.5 1 1 1 2 2 2 0 Tumour protein D52 family HIP1_clath_bdg PF16515.5 EMD59698.1 - 0.56 10.9 19.1 0.94 10.1 1.0 3.7 1 1 3 4 4 4 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Spc7 PF08317.11 EMD59698.1 - 0.98 8.2 18.7 2.7 6.8 6.2 2.5 1 1 1 2 2 2 0 Spc7 kinetochore protein Tropomyosin_1 PF12718.7 EMD59698.1 - 1 9.5 18.2 3 8.0 15.8 2.4 1 1 1 2 2 2 0 Tropomyosin like Baculo_PEP_C PF04513.12 EMD59698.1 - 1.1 9.4 9.5 13 5.8 9.5 2.5 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Phage_GPO PF05929.11 EMD59698.1 - 1.1 8.9 11.2 0.76 9.4 2.5 2.1 1 1 0 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase AAA_23 PF13476.6 EMD59698.1 - 1.2 9.6 12.2 1.7 9.1 12.2 1.3 1 0 0 1 1 1 0 AAA domain LOH1CR12 PF10158.9 EMD59698.1 - 1.2 9.2 6.5 4 7.5 1.9 2.9 1 1 2 3 3 3 0 Tumour suppressor protein Prominin PF05478.11 EMD59698.1 - 1.3 6.9 7.2 2 6.3 6.9 1.4 1 1 0 1 1 1 0 Prominin PI_PP_I PF18363.1 EMD59698.1 - 2.2 8.5 5.0 1.4 9.1 0.7 2.4 2 1 1 3 3 3 0 Phosphoinositide phosphatase insertion domain Snapin_Pallidin PF14712.6 EMD59698.1 - 2.6 8.5 15.1 4.6 7.7 0.7 2.9 2 2 1 3 3 3 0 Snapin/Pallidin COG2 PF06148.11 EMD59698.1 - 2.7 8.1 12.2 13 5.9 2.2 3.3 1 1 2 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 RasGAP_C PF03836.15 EMD59698.1 - 2.8 8.1 12.8 6.8 6.8 4.0 2.4 1 1 1 2 2 2 0 RasGAP C-terminus Dynamin_N PF00350.23 EMD59698.1 - 2.8 8.0 6.4 21 5.1 6.4 2.2 1 1 0 1 1 1 0 Dynamin family CK2S PF15011.6 EMD59698.1 - 3.4 7.5 13.2 6.8 6.6 5.7 2.7 1 1 2 3 3 3 0 Casein Kinase 2 substrate FlaC_arch PF05377.11 EMD59698.1 - 3.4 8.1 9.7 1.7 9.1 0.6 3.3 3 1 1 4 4 3 0 Flagella accessory protein C (FlaC) DHR10 PF18595.1 EMD59698.1 - 3.5 7.7 22.4 9.8 6.3 7.2 2.7 1 1 0 2 2 2 0 Designed helical repeat protein 10 domain FapA PF03961.13 EMD59698.1 - 3.6 6.1 13.6 0.77 8.3 3.1 2.0 1 1 0 2 2 2 0 Flagellar Assembly Protein A CENP-F_leu_zip PF10473.9 EMD59698.1 - 3.7 7.6 19.6 4.6 7.3 4.8 3.1 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ParB PF08775.10 EMD59698.1 - 4 7.9 8.9 0.48 10.9 1.5 2.2 1 1 1 2 2 2 0 ParB family ATG16 PF08614.11 EMD59698.1 - 4 7.6 21.9 3.3 7.9 6.4 2.7 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) TetR_C_37 PF18665.1 EMD59698.1 - 4.4 7.9 7.3 4.9 7.8 0.6 2.7 3 1 0 3 3 2 0 Tetracyclin repressor-like, C-terminal domain DUF4446 PF14584.6 EMD59698.1 - 4.9 7.1 12.1 6.2 6.8 1.1 3.0 1 1 2 3 3 3 0 Protein of unknown function (DUF4446) Uds1 PF15456.6 EMD59698.1 - 5.2 7.2 13.3 0.52 10.5 1.6 2.9 1 1 2 3 3 3 0 Up-regulated During Septation GAS PF13851.6 EMD59698.1 - 5.5 6.3 19.7 1 8.7 5.4 2.2 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding SlyX PF04102.12 EMD59698.1 - 5.6 7.7 18.0 20 5.9 3.5 4.0 1 1 2 4 4 4 0 SlyX DUF4164 PF13747.6 EMD59698.1 - 7.4 6.9 15.7 1.4 9.2 3.5 3.3 2 2 0 2 2 2 0 Domain of unknown function (DUF4164) Occludin_ELL PF07303.13 EMD59698.1 - 8.1 7.2 14.3 3.4e+03 -1.2 14.3 3.1 1 1 0 1 1 0 0 Occludin homology domain Atg14 PF10186.9 EMD59698.1 - 9.6 5.2 11.4 24 3.9 11.4 1.8 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF724 PF05266.14 EMD59698.1 - 9.7 6.0 15.1 1.4 8.7 4.4 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF724) MFS_1 PF07690.16 EMD59699.1 - 3.1e-34 118.4 15.7 3.1e-34 118.4 15.7 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily Amidase PF01425.21 EMD59700.1 - 3.2e-108 362.6 0.0 4.1e-108 362.2 0.0 1.1 1 0 0 1 1 1 1 Amidase MFS_1 PF07690.16 EMD59701.1 - 5.1e-06 25.6 34.7 8.3e-06 25.0 23.7 2.5 2 1 0 2 2 2 2 Major Facilitator Superfamily ISG65-75 PF11727.8 EMD59701.1 - 0.16 11.2 0.1 0.25 10.6 0.1 1.2 1 0 0 1 1 1 0 Invariant surface glycoprotein Cecropin PF00272.19 EMD59701.1 - 2.3 8.0 3.7 11 5.9 1.0 2.6 2 0 0 2 2 2 0 Cecropin family ATP-synt_G PF04718.15 EMD59702.1 - 2.8e-34 117.9 1.4 5.6e-34 116.9 0.1 1.9 2 0 0 2 2 2 1 Mitochondrial ATP synthase g subunit Suf PF05843.14 EMD59702.1 - 0.0044 17.0 2.3 0.18 11.8 0.2 2.0 1 1 1 2 2 2 2 Suppressor of forked protein (Suf) ApoLp-III PF07464.11 EMD59702.1 - 0.09 12.9 3.5 0.43 10.7 1.7 2.0 2 0 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) DUF883 PF05957.13 EMD59702.1 - 0.1 13.2 6.7 0.38 11.4 2.0 2.4 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF883) LemA PF04011.12 EMD59702.1 - 0.54 10.1 3.9 1.6 8.6 0.1 2.2 2 0 0 2 2 2 0 LemA family RAP1 PF07218.11 EMD59702.1 - 0.68 8.1 1.6 0.71 8.1 1.6 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) DUF4692 PF15763.5 EMD59702.1 - 1 9.8 4.9 0.45 11.0 1.9 1.7 2 0 0 2 2 2 0 Regulator of human erythroid cell expansion (RHEX) TFIIA PF03153.13 EMD59702.1 - 4 7.3 8.5 5 7.0 8.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Ribosomal_60s PF00428.19 EMD59702.1 - 6.2 7.5 9.3 1.2 9.8 5.7 1.7 2 0 0 2 2 2 0 60s Acidic ribosomal protein DEAD PF00270.29 EMD59703.1 - 2.1e-26 92.8 0.1 3.6e-25 88.7 0.1 2.3 1 1 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EMD59703.1 - 1.4e-23 83.4 0.0 6.5e-23 81.2 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EMD59703.1 - 6.2e-06 26.3 0.0 6.2e-06 26.3 0.0 2.4 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit UTP25 PF06862.12 EMD59703.1 - 0.0045 15.8 0.0 0.024 13.4 0.0 1.9 2 0 0 2 2 2 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 Ima1_N PF09779.9 EMD59703.1 - 10 7.0 7.2 27 5.6 7.2 1.7 1 0 0 1 1 1 0 Ima1 N-terminal domain Glyco_tranf_2_3 PF13641.6 EMD59705.1 - 1.2e-28 100.6 0.0 1.7e-28 100.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 EMD59705.1 - 2.7e-09 37.1 0.0 4.6e-09 36.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_trans_2_3 PF13632.6 EMD59705.1 - 1.3e-06 28.5 3.4 1.3e-06 28.5 3.4 2.1 3 0 0 3 3 3 1 Glycosyl transferase family group 2 Glyco_transf_21 PF13506.6 EMD59705.1 - 4.2e-06 26.3 0.0 0.0003 20.3 0.0 2.2 2 0 0 2 2 2 2 Glycosyl transferase family 21 Amidohydro_2 PF04909.14 EMD59707.1 - 2.7e-12 47.1 0.0 1.6e-11 44.6 0.0 1.9 2 0 0 2 2 2 1 Amidohydrolase Clr5 PF14420.6 EMD59708.1 - 8.2e-16 58.0 0.8 9e-15 54.6 0.4 2.6 2 0 0 2 2 2 1 Clr5 domain Arg_repressor PF01316.21 EMD59708.1 - 0.056 13.2 0.1 0.19 11.5 0.1 1.8 1 0 0 1 1 1 0 Arginine repressor, DNA binding domain DUF3490 PF11995.8 EMD59708.1 - 0.057 13.2 1.4 0.11 12.3 0.1 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF3490) Nif11 PF07862.11 EMD59708.1 - 0.46 10.8 6.6 1.1 9.6 0.0 4.3 5 0 0 5 5 5 0 Nif11 domain adh_short_C2 PF13561.6 EMD59709.1 - 2e-56 191.2 0.0 4.4e-56 190.0 0.0 1.5 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EMD59709.1 - 9.6e-41 139.4 0.1 2.7e-40 137.9 0.1 1.6 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EMD59709.1 - 4.2e-10 39.8 0.1 6.7e-10 39.2 0.1 1.2 1 0 0 1 1 1 1 KR domain GATA PF00320.27 EMD59710.1 - 2.7e-16 58.9 6.1 5.6e-16 57.8 6.1 1.6 1 0 0 1 1 1 1 GATA zinc finger PAS_3 PF08447.12 EMD59710.1 - 1.4e-13 50.9 0.0 3.3e-13 49.7 0.0 1.6 1 0 0 1 1 1 1 PAS fold PAS PF00989.25 EMD59710.1 - 3.7e-09 36.6 0.0 8.8e-09 35.4 0.0 1.6 1 0 0 1 1 1 1 PAS fold PAS_4 PF08448.10 EMD59710.1 - 1.1e-07 32.1 0.0 2.2e-07 31.1 0.0 1.5 1 0 0 1 1 1 1 PAS fold PAS_11 PF14598.6 EMD59710.1 - 2.9e-06 27.4 0.0 5.7e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 PAS domain PAS_9 PF13426.7 EMD59710.1 - 0.0019 18.4 0.0 0.0069 16.6 0.0 1.9 2 0 0 2 2 2 1 PAS domain Zn-ribbon_8 PF09723.10 EMD59710.1 - 0.0064 16.6 0.2 0.014 15.5 0.2 1.6 1 0 0 1 1 1 1 Zinc ribbon domain DUF4428 PF14471.6 EMD59710.1 - 0.051 13.5 0.9 0.051 13.5 0.9 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4428) TF_Zn_Ribbon PF08271.12 EMD59710.1 - 0.22 11.0 0.6 1.5 8.4 0.1 2.3 2 0 0 2 2 2 0 TFIIB zinc-binding DHQ_synthase PF01761.20 EMD59711.1 - 0.12 11.5 0.1 10 5.2 0.0 2.0 1 1 1 2 2 2 0 3-dehydroquinate synthase Beta-lactamase PF00144.24 EMD59713.1 - 9.6e-36 123.7 0.2 1.4e-35 123.2 0.2 1.2 1 0 0 1 1 1 1 Beta-lactamase Beta-lactamase2 PF13354.6 EMD59713.1 - 0.00062 19.4 0.0 0.0018 17.9 0.0 1.7 2 0 0 2 2 2 1 Beta-lactamase enzyme family ThiF PF00899.21 EMD59714.1 - 8e-59 198.9 0.0 1.2e-58 198.4 0.0 1.2 1 0 0 1 1 1 1 ThiF family Rhodanese PF00581.20 EMD59714.1 - 1.4e-09 38.4 0.0 6e-09 36.4 0.0 2.0 2 0 0 2 2 2 1 Rhodanese-like domain NAD_binding_7 PF13241.6 EMD59714.1 - 0.0089 16.4 0.0 0.024 15.1 0.0 1.7 1 0 0 1 1 1 1 Putative NAD(P)-binding Fez1 PF06818.15 EMD59714.1 - 0.029 14.8 0.7 0.055 13.9 0.7 1.4 1 0 0 1 1 1 0 Fez1 SlyX PF04102.12 EMD59714.1 - 0.3 11.7 2.0 0.69 10.6 2.0 1.6 1 0 0 1 1 1 0 SlyX HET PF06985.11 EMD59715.1 - 2.4e-18 66.9 0.0 5.4e-18 65.8 0.0 1.6 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) SLX9 PF15341.6 EMD59716.1 - 9.5e-29 100.4 12.2 1.5e-28 99.8 12.2 1.3 1 0 0 1 1 1 1 Ribosome biogenesis protein SLX9 DDE_Tnp_4 PF13359.6 EMD59716.1 - 0.027 14.1 2.1 0.06 13.0 2.1 1.7 1 1 0 1 1 1 0 DDE superfamily endonuclease YAcAr PF10686.9 EMD59716.1 - 0.059 13.3 0.1 0.1 12.5 0.1 1.4 1 0 0 1 1 1 0 YspA, cpYpsA-related SLOG family ATP1G1_PLM_MAT8 PF02038.16 EMD59717.1 - 8.2 6.0 8.1 2.5 7.6 1.4 2.9 3 0 0 3 3 3 0 ATP1G1/PLM/MAT8 family Zip PF02535.22 EMD59718.1 - 7.7e-57 193.0 1.7 1e-56 192.6 1.7 1.2 1 0 0 1 1 1 1 ZIP Zinc transporter DUF4514 PF14986.6 EMD59718.1 - 2.7 8.0 4.4 9.9 6.2 0.1 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4514) MMM1 PF10296.9 EMD59720.1 - 0.0001 21.5 0.0 0.00052 19.2 0.0 2.0 2 1 0 2 2 2 1 Maintenance of mitochondrial morphology protein 1 Catalase PF00199.19 EMD59725.1 - 3.2e-173 576.2 0.3 4.5e-173 575.7 0.3 1.2 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.12 EMD59725.1 - 3.4e-17 62.4 0.1 6.5e-17 61.5 0.1 1.5 1 0 0 1 1 1 1 Catalase-related immune-responsive Catalase_C PF18011.1 EMD59725.1 - 2.1e-10 40.4 0.7 4.4e-10 39.4 0.7 1.6 1 0 0 1 1 1 1 C-terminal domain found in long catalases DJ-1_PfpI PF01965.24 EMD59725.1 - 2.8e-08 33.7 0.0 5.3e-08 32.8 0.0 1.5 1 0 0 1 1 1 1 DJ-1/PfpI family Pkinase PF00069.25 EMD59726.1 - 4.1e-39 134.5 0.0 6.4e-39 133.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD59726.1 - 5.1e-22 78.4 0.0 8.2e-22 77.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase HET PF06985.11 EMD59726.1 - 9.7e-21 74.7 0.1 2.7e-20 73.2 0.1 1.9 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) RRP7 PF12923.7 EMD59727.1 - 1.6e-30 105.6 2.6 2.6e-30 105.0 2.6 1.3 1 0 0 1 1 1 1 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain RRM_Rrp7 PF17799.1 EMD59727.1 - 2.9e-20 72.7 0.0 9.5e-20 71.0 0.0 1.8 1 1 0 1 1 1 1 Rrp7 RRM-like N-terminal domain RRM_1 PF00076.22 EMD59727.1 - 0.0081 16.0 0.2 0.074 12.9 0.0 2.7 4 0 0 4 4 4 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ysc84 PF04366.12 EMD59728.1 - 1.4e-44 151.0 0.0 2e-44 150.4 0.0 1.3 1 0 0 1 1 1 1 Las17-binding protein actin regulator Cwf_Cwc_15 PF04889.12 EMD59728.1 - 0.032 14.0 3.4 0.061 13.1 3.4 1.4 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein PBP1_TM PF14812.6 EMD59728.1 - 0.051 13.9 2.6 0.13 12.6 2.6 1.7 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF4611 PF15387.6 EMD59728.1 - 0.6 10.4 5.6 0.64 10.3 3.8 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) DNA_pol_phi PF04931.13 EMD59728.1 - 0.67 8.0 1.8 0.97 7.5 1.8 1.1 1 0 0 1 1 1 0 DNA polymerase phi Pox_Ag35 PF03286.14 EMD59728.1 - 0.86 9.4 6.9 2.1 8.1 6.9 1.7 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Nucleopor_Nup85 PF07575.13 EMD59729.1 - 1.1e-28 100.2 0.0 3.6e-27 95.2 0.0 2.4 1 1 0 1 1 1 1 Nup85 Nucleoporin PBP1_TM PF14812.6 EMD59729.1 - 0.14 12.5 7.6 0.44 10.9 7.6 1.8 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal NOA36 PF06524.12 EMD59729.1 - 0.52 9.6 6.5 0.82 8.9 6.5 1.2 1 0 0 1 1 1 0 NOA36 protein BTB PF00651.31 EMD59731.1 - 5.3e-08 33.1 0.0 1.6e-07 31.6 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain PCI PF01399.27 EMD59733.1 - 2.4e-13 50.5 0.0 5.2e-13 49.4 0.0 1.6 1 0 0 1 1 1 1 PCI domain TPR_2 PF07719.17 EMD59733.1 - 0.0082 16.2 1.6 0.16 12.2 0.3 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat Ribosomal_L18A PF01775.17 EMD59734.1 - 2e-53 179.6 2.2 2.5e-53 179.3 2.2 1.1 1 0 0 1 1 1 1 Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A ECH_1 PF00378.20 EMD59735.1 - 5.6e-44 150.3 0.0 7e-44 150.0 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EMD59735.1 - 5.6e-21 75.4 0.1 7.4e-21 75.0 0.1 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase HET PF06985.11 EMD59736.1 - 1.5e-31 109.7 0.1 4.8e-31 108.1 0.1 1.9 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) HHH_5 PF14520.6 EMD59739.1 - 2.9e-07 31.0 0.4 5.5e-07 30.1 0.1 1.6 2 0 0 2 2 2 1 Helix-hairpin-helix domain RNA_pol_A_CTD PF03118.15 EMD59739.1 - 0.025 14.3 0.0 0.05 13.4 0.0 1.5 1 0 0 1 1 1 0 Bacterial RNA polymerase, alpha chain C terminal domain UDPGP PF01704.18 EMD59741.1 - 2.6e-58 197.6 0.0 3.7e-58 197.1 0.0 1.1 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase MR_MLE_C PF13378.6 EMD59741.1 - 3.5e-41 141.2 0.0 5.7e-41 140.5 0.0 1.2 1 0 0 1 1 1 1 Enolase C-terminal domain-like MR_MLE_N PF02746.16 EMD59741.1 - 1.6e-07 31.5 0.0 3.3e-07 30.5 0.0 1.5 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain Fungal_trans PF04082.18 EMD59742.1 - 9.8e-28 96.9 0.4 1.5e-27 96.3 0.4 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD59742.1 - 1.3e-08 34.8 10.5 2.3e-08 34.0 10.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DAO PF01266.24 EMD59743.1 - 1.1e-27 97.5 0.4 2.4e-27 96.5 0.4 1.5 1 1 0 1 1 1 1 FAD dependent oxidoreductase Glu_dehyd_C PF16912.5 EMD59743.1 - 0.18 11.2 0.0 0.41 10.1 0.0 1.5 2 0 0 2 2 2 0 Glucose dehydrogenase C-terminus Mei5 PF10376.9 EMD59744.1 - 0.017 15.0 11.7 0.22 11.4 11.7 2.8 1 1 0 1 1 1 0 Double-strand recombination repair protein Lipocalin PF00061.23 EMD59744.1 - 0.025 14.8 0.6 0.041 14.1 0.6 1.3 1 0 0 1 1 1 0 Lipocalin / cytosolic fatty-acid binding protein family CT47 PF15623.6 EMD59744.1 - 0.064 13.1 8.5 0.1 12.4 8.5 1.3 1 0 0 1 1 1 0 Cancer/testis gene family 47 GWT1 PF06423.12 EMD59745.1 - 4.5e-42 143.7 0.7 2.1e-41 141.5 1.3 1.8 2 0 0 2 2 2 1 GWT1 DUF4818 PF16089.5 EMD59745.1 - 0.0007 20.1 0.1 0.0055 17.2 0.0 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4818) TraA PF05513.11 EMD59745.1 - 0.016 15.6 0.1 0.036 14.4 0.1 1.6 1 0 0 1 1 1 0 TraA DUF4896 PF16237.5 EMD59745.1 - 0.018 14.9 1.1 0.74 9.7 0.6 3.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4896) zf-Tim10_DDP PF02953.15 EMD59747.1 - 3e-20 71.6 2.2 3.7e-20 71.3 2.2 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger WD40 PF00400.32 EMD59749.1 - 4.3e-73 239.4 64.3 1.7e-12 47.6 1.7 9.7 9 1 0 9 9 9 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD59749.1 - 2.7e-30 104.5 13.6 7.1e-05 23.0 0.1 7.5 2 1 5 7 7 7 7 Anaphase-promoting complex subunit 4 WD40 domain NACHT PF05729.12 EMD59749.1 - 2.6e-27 95.8 0.2 5.2e-27 94.8 0.2 1.5 1 0 0 1 1 1 1 NACHT domain Nup160 PF11715.8 EMD59749.1 - 1.7e-13 50.1 30.2 0.025 13.2 0.1 7.1 3 1 4 7 7 7 7 Nucleoporin Nup120/160 HET PF06985.11 EMD59749.1 - 1.5e-12 48.1 7.2 3.9e-10 40.3 0.1 4.0 2 1 1 3 3 3 2 Heterokaryon incompatibility protein (HET) Ge1_WD40 PF16529.5 EMD59749.1 - 4.4e-12 45.6 28.8 0.0043 16.0 1.9 6.1 2 2 4 6 6 6 6 WD40 region of Ge1, enhancer of mRNA-decapping protein FlgD_ig PF13860.6 EMD59749.1 - 3.1e-05 23.7 1.5 16 5.5 0.1 5.3 4 1 1 5 5 5 2 FlgD Ig-like domain CDtoxinA PF03498.14 EMD59749.1 - 0.0034 17.0 0.0 2.6 7.6 0.0 4.5 2 1 3 5 5 5 1 Cytolethal distending toxin A/C domain Cytochrom_D1 PF02239.16 EMD59749.1 - 0.065 11.8 2.9 5.1 5.5 0.3 3.3 3 1 0 3 3 3 0 Cytochrome D1 heme domain AAA_16 PF13191.6 EMD59749.1 - 0.12 12.7 0.0 0.35 11.2 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain FAD-oxidase_C PF02913.19 EMD59750.1 - 4.4e-63 213.2 0.1 7.7e-63 212.4 0.1 1.4 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 EMD59750.1 - 1e-38 132.2 0.0 4.1e-38 130.3 0.0 2.0 2 0 0 2 2 2 1 FAD binding domain NUP50 PF08911.11 EMD59753.1 - 0.00041 21.0 6.2 0.00041 21.0 6.2 14.7 10 5 0 10 10 10 1 NUP50 (Nucleoporin 50 kDa) Lactamase_B_3 PF13483.6 EMD59754.1 - 2.3e-05 24.3 0.1 6e-05 23.0 0.0 1.7 2 0 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B_2 PF12706.7 EMD59754.1 - 0.0049 16.4 0.2 0.014 15.0 0.2 1.8 1 1 0 1 1 1 1 Beta-lactamase superfamily domain CoA_transf_3 PF02515.17 EMD59755.1 - 1.1e-35 123.4 0.1 1.8e-34 119.5 0.0 2.1 2 0 0 2 2 2 2 CoA-transferase family III HET PF06985.11 EMD59756.1 - 7.5e-14 52.3 1.1 3.1e-13 50.3 1.1 2.1 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) SPRY PF00622.28 EMD59757.1 - 9.9e-05 22.4 0.1 0.00028 21.0 0.0 1.8 2 0 0 2 2 2 1 SPRY domain CLTH PF10607.9 EMD59758.1 - 2.5e-29 102.1 0.0 8.4e-29 100.4 0.0 1.8 2 0 0 2 2 2 1 CTLH/CRA C-terminal to LisH motif domain zf-RING_UBOX PF13445.6 EMD59758.1 - 7.4e-08 32.3 0.3 1.5e-07 31.3 0.3 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 EMD59758.1 - 0.00031 20.6 0.2 0.00059 19.7 0.2 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 EMD59758.1 - 0.0011 19.3 0.5 0.0022 18.3 0.5 1.6 1 0 0 1 1 1 1 Ring finger domain Rtf2 PF04641.12 EMD59758.1 - 0.0019 17.6 0.3 0.0033 16.9 0.0 1.5 2 0 0 2 2 2 1 Rtf2 RING-finger zf-C3HC4_2 PF13923.6 EMD59758.1 - 0.0082 16.0 1.1 0.016 15.0 1.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EMD59758.1 - 0.0083 16.0 0.9 0.015 15.1 0.9 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 EMD59758.1 - 0.044 13.7 0.3 0.087 12.7 0.3 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EMD59758.1 - 0.062 13.5 0.2 0.15 12.3 0.2 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.25 EMD59758.1 - 0.095 12.6 0.7 0.19 11.6 0.7 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) PG_binding_1 PF01471.18 EMD59759.1 - 0.00099 19.3 0.0 0.19 12.0 0.0 3.3 3 0 0 3 3 3 1 Putative peptidoglycan binding domain DUF812 PF05667.11 EMD59759.1 - 0.022 13.7 2.0 0.055 12.4 1.9 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF812) DUF4618 PF15397.6 EMD59759.1 - 0.23 10.8 4.5 0.11 11.8 0.3 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4618) DUF1664 PF07889.12 EMD59759.1 - 0.41 10.7 1.9 0.63 10.1 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Prominin PF05478.11 EMD59759.1 - 1.5 6.6 4.1 2.2 6.2 4.1 1.1 1 0 0 1 1 1 0 Prominin Syntaxin-6_N PF09177.11 EMD59759.1 - 4.8 7.8 6.7 1.2 9.8 0.9 2.7 1 1 1 2 2 2 0 Syntaxin 6, N-terminal Glyco_transf_28 PF03033.20 EMD59760.1 - 2.5e-18 66.5 0.0 2.4e-11 43.8 0.0 2.6 2 0 0 2 2 2 2 Glycosyltransferase family 28 N-terminal domain UDPGT PF00201.18 EMD59760.1 - 6.5e-05 21.9 0.0 0.00012 21.0 0.0 1.4 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase ATG_C PF09333.11 EMD59760.1 - 0.0023 18.2 0.0 0.0077 16.6 0.0 1.9 1 0 0 1 1 1 1 Autophagy-related protein C terminal domain Glyco_tran_28_C PF04101.16 EMD59760.1 - 0.025 14.5 0.0 0.025 14.5 0.0 2.5 3 0 0 3 3 3 0 Glycosyltransferase family 28 C-terminal domain DUF1929 PF09118.11 EMD59761.1 - 8.9e-24 83.6 0.0 1.7e-23 82.7 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1929) Kelch_4 PF13418.6 EMD59761.1 - 5.9e-12 45.4 4.6 0.0046 16.9 0.0 5.0 4 1 0 4 4 4 3 Galactose oxidase, central domain Kelch_6 PF13964.6 EMD59761.1 - 1.7e-10 40.8 4.3 0.00071 19.8 0.0 5.3 4 1 2 6 6 6 3 Kelch motif Kelch_1 PF01344.25 EMD59761.1 - 9e-06 25.2 0.0 0.07 12.7 0.0 3.4 3 0 0 3 3 3 2 Kelch motif Glyoxal_oxid_N PF07250.11 EMD59761.1 - 1.3e-05 24.5 0.0 0.11 11.6 0.0 3.0 2 1 1 3 3 3 2 Glyoxal oxidase N-terminus Kelch_2 PF07646.15 EMD59761.1 - 0.0012 18.8 4.6 6.7 6.9 0.0 4.9 4 2 0 4 4 4 1 Kelch motif DUF5122 PF17164.4 EMD59761.1 - 5.2 7.5 7.5 2.4 8.5 0.1 3.6 4 0 0 4 4 4 0 Domain of unknown function (DUF5122) beta-propeller HPP PF04982.13 EMD59762.1 - 4.8e-38 130.1 8.7 6.9e-38 129.6 7.3 1.8 2 0 0 2 2 2 1 HPP family Tmemb_14 PF03647.13 EMD59762.1 - 0.16 12.7 5.4 0.92 10.3 2.6 2.6 2 1 0 2 2 2 0 Transmembrane proteins 14C SirB PF04247.12 EMD59762.1 - 0.52 10.4 6.1 8.7 6.5 1.1 2.5 2 1 0 2 2 2 0 Invasion gene expression up-regulator, SirB Amidohydro_3 PF07969.11 EMD59764.1 - 1.4e-56 193.0 0.1 1.7e-56 192.7 0.1 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_1 PF01979.20 EMD59764.1 - 9.4e-15 54.8 0.1 3.7e-11 42.9 0.0 3.3 2 1 0 2 2 2 2 Amidohydrolase family zinc_ribbon_5 PF13719.6 EMD59765.1 - 0.0022 17.7 2.7 0.011 15.4 2.7 2.0 1 1 0 1 1 1 1 zinc-ribbon domain zinc_ribbon_4 PF13717.6 EMD59765.1 - 0.0051 16.7 2.7 0.13 12.2 2.7 2.1 1 1 0 1 1 1 1 zinc-ribbon domain zinc-ribbons_6 PF07191.12 EMD59765.1 - 0.035 14.1 0.5 0.048 13.6 0.5 1.2 1 0 0 1 1 1 0 zinc-ribbons Zn-ribbon_8 PF09723.10 EMD59765.1 - 0.053 13.6 1.6 6.6 6.9 0.2 2.3 2 0 0 2 2 2 0 Zinc ribbon domain zf-ribbon_3 PF13248.6 EMD59765.1 - 0.17 11.3 5.1 3.2 7.3 5.4 2.2 1 1 1 2 2 2 0 zinc-ribbon domain Fungus-induced PF10917.8 EMD59765.1 - 0.3 11.4 1.8 0.46 10.8 1.8 1.3 1 0 0 1 1 1 0 Fungus-induced protein zf-ACC PF17848.1 EMD59765.1 - 1 9.5 5.9 5.2 7.2 0.5 2.3 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain ADH_N PF08240.12 EMD59766.1 - 6e-20 71.2 1.5 7.7e-20 70.8 0.0 1.9 3 0 0 3 3 3 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EMD59766.1 - 9.2e-18 64.5 0.2 1.6e-17 63.7 0.2 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EMD59766.1 - 3.1e-06 26.8 0.8 2.7e-05 23.8 0.8 2.2 1 1 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 EMD59766.1 - 8.2e-05 23.7 0.0 0.00021 22.4 0.0 1.7 1 1 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 EMD59766.1 - 0.00064 19.1 1.0 0.00093 18.5 1.0 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox_2 PF07992.14 EMD59766.1 - 0.013 14.8 1.0 0.022 14.0 0.8 1.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EMD59766.1 - 0.031 14.8 2.9 0.91 10.1 2.8 2.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EMD59766.1 - 0.075 12.1 1.9 0.095 11.8 1.9 1.2 1 0 0 1 1 1 0 FAD binding domain HI0933_like PF03486.14 EMD59766.1 - 0.1 11.3 1.4 0.16 10.7 1.4 1.2 1 0 0 1 1 1 0 HI0933-like protein 3HCDH_N PF02737.18 EMD59766.1 - 0.15 11.9 0.4 0.23 11.3 0.4 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.14 EMD59766.1 - 0.16 11.5 1.0 0.25 10.9 1.0 1.2 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 2-Hacid_dh_C PF02826.19 EMD59766.1 - 0.18 11.2 0.5 0.3 10.4 0.5 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain SCP2 PF02036.17 EMD59767.1 - 8.1e-25 87.3 0.6 9.4e-25 87.0 0.6 1.1 1 0 0 1 1 1 1 SCP-2 sterol transfer family Alkyl_sulf_C PF14864.6 EMD59767.1 - 1.1e-10 41.8 0.1 1.4e-10 41.5 0.1 1.1 1 0 0 1 1 1 1 Alkyl sulfatase C-terminal SCP2_2 PF13530.6 EMD59767.1 - 0.032 14.6 0.0 0.038 14.4 0.0 1.2 1 0 0 1 1 1 0 Sterol carrier protein domain DUF402 PF04167.13 EMD59767.1 - 0.14 12.4 0.0 0.19 11.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF402) F-box PF00646.33 EMD59768.1 - 0.019 14.8 0.4 0.056 13.3 0.4 1.8 1 0 0 1 1 1 0 F-box domain Arrestin_N PF00339.29 EMD59769.1 - 5e-11 42.9 0.0 1.2e-09 38.3 0.0 2.5 1 1 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Bul1_C PF04426.12 EMD59769.1 - 0.054 12.9 0.0 0.11 11.9 0.0 1.5 1 0 0 1 1 1 0 Bul1 C terminus V-ATPase_G PF03179.15 EMD59771.1 - 3.1e-32 111.2 16.5 3.5e-32 111.1 16.5 1.0 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit Sds3 PF08598.11 EMD59771.1 - 0.036 14.1 9.6 0.046 13.7 9.6 1.1 1 0 0 1 1 1 0 Sds3-like DUF3552 PF12072.8 EMD59771.1 - 0.064 12.7 19.2 0.29 10.5 18.8 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF3552) RRF PF01765.19 EMD59771.1 - 0.066 13.2 11.6 0.087 12.8 11.6 1.3 1 0 0 1 1 1 0 Ribosome recycling factor OmpH PF03938.14 EMD59771.1 - 0.24 11.8 15.1 0.29 11.5 15.1 1.1 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) RGS-like PF09128.11 EMD59771.1 - 0.26 11.0 5.5 0.28 10.9 5.5 1.1 1 0 0 1 1 1 0 Regulator of G protein signalling-like domain ATP-synt_B PF00430.18 EMD59771.1 - 0.36 10.9 19.4 3.1 7.9 18.7 2.0 1 1 0 1 1 1 0 ATP synthase B/B' CF(0) DUF2203 PF09969.9 EMD59771.1 - 0.61 10.8 5.9 0.84 10.4 5.9 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) V-ATPase_G_2 PF16999.5 EMD59771.1 - 0.66 10.4 14.7 1 9.8 14.7 1.4 1 0 0 1 1 1 0 Vacuolar (H+)-ATPase G subunit ATP11 PF06644.11 EMD59771.1 - 0.72 9.6 9.8 0.89 9.3 9.8 1.0 1 0 0 1 1 1 0 ATP11 protein DUF3450 PF11932.8 EMD59771.1 - 1.3 8.3 11.3 1.4 8.2 11.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) DUF4407 PF14362.6 EMD59771.1 - 7.3 5.8 11.1 8.4 5.6 11.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF883 PF05957.13 EMD59771.1 - 7.4 7.2 9.8 22 5.8 7.4 2.0 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) PET117 PF15786.5 EMD59772.1 - 6.1e-24 84.1 2.4 7.1e-24 83.9 2.4 1.1 1 0 0 1 1 1 1 PET assembly of cytochrome c oxidase, mitochondrial Tic110 PF16940.5 EMD59772.1 - 0.069 11.6 0.7 0.08 11.4 0.7 1.1 1 0 0 1 1 1 0 Chloroplast envelope transporter GRP PF07172.11 EMD59773.1 - 0.00014 22.5 8.3 0.00038 21.1 8.3 1.7 1 0 0 1 1 1 1 Glycine rich protein family DUF4115 PF13464.6 EMD59773.1 - 0.069 13.4 0.0 0.11 12.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4115) SR-25 PF10500.9 EMD59773.1 - 0.54 9.8 2.3 0.86 9.2 2.3 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein AMPK1_CBM PF16561.5 EMD59775.1 - 1.7e-05 24.9 0.0 3.5e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase DUF4644 PF15486.6 EMD59775.1 - 8.5 6.1 8.7 0.27 11.0 1.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4644) ADIP PF11559.8 EMD59777.1 - 9.9e-43 145.8 11.0 9.9e-43 145.8 11.0 1.9 2 0 0 2 2 2 1 Afadin- and alpha -actinin-Binding Golgin_A5 PF09787.9 EMD59777.1 - 0.0006 19.4 9.4 0.0006 19.4 9.4 2.6 2 1 0 2 2 2 1 Golgin subfamily A member 5 DUF641 PF04859.12 EMD59777.1 - 0.046 14.0 10.4 0.76 10.1 7.7 3.2 2 1 0 2 2 2 0 Plant protein of unknown function (DUF641) DUF725 PF05267.12 EMD59777.1 - 0.99 9.4 4.3 2.1 8.4 4.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF725) DUF2570 PF10828.8 EMD59777.1 - 1.5 8.7 5.1 3.9 7.3 5.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2570) BORCS6 PF10157.9 EMD59777.1 - 1.6 9.0 5.5 1.7 8.9 0.0 2.8 3 0 0 3 3 3 0 BLOC-1-related complex sub-unit 6 Nup88 PF10168.9 EMD59777.1 - 2.2 6.0 10.2 14 3.3 7.3 2.1 2 0 0 2 2 2 0 Nuclear pore component FAD_binding_4 PF01565.23 EMD59778.1 - 5.2e-19 68.4 0.5 7.9e-19 67.8 0.5 1.3 1 0 0 1 1 1 1 FAD binding domain Abhydrolase_1 PF00561.20 EMD59779.1 - 4.6e-33 114.9 0.1 7.2e-33 114.3 0.1 1.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EMD59779.1 - 6.9e-13 48.4 0.0 4.8e-12 45.7 0.0 2.0 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EMD59779.1 - 3.3e-10 40.9 0.1 4.8e-10 40.4 0.1 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_4 PF08386.10 EMD59779.1 - 0.00037 20.6 0.0 0.00067 19.7 0.0 1.4 1 0 0 1 1 1 1 TAP-like protein Esterase PF00756.20 EMD59779.1 - 0.02 14.6 0.1 0.065 12.9 0.1 2.0 1 1 0 1 1 1 0 Putative esterase Peptidase_S15 PF02129.18 EMD59779.1 - 0.022 14.4 0.1 0.038 13.6 0.1 1.5 1 1 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Peptidase_S28 PF05577.12 EMD59779.1 - 0.073 11.9 0.0 0.11 11.3 0.0 1.2 1 0 0 1 1 1 0 Serine carboxypeptidase S28 C166 PF17615.2 EMD59780.1 - 1.1e-36 126.3 9.4 1.4e-36 126.0 9.4 1.1 1 0 0 1 1 1 1 Family of unknown function HsbA PF12296.8 EMD59780.1 - 5.1e-06 26.9 3.8 2.5e-05 24.7 3.4 2.2 1 1 0 1 1 1 1 Hydrophobic surface binding protein A Fungal_trans_2 PF11951.8 EMD59782.1 - 4.8e-06 25.6 0.3 8e-06 24.9 0.0 1.5 2 0 0 2 2 2 1 Fungal specific transcription factor domain RTA1 PF04479.13 EMD59783.1 - 1.7e-60 204.2 1.7 1.7e-60 204.2 1.7 1.7 1 1 1 2 2 2 1 RTA1 like protein BIV_Env PF05858.12 EMD59783.1 - 0.0075 14.5 0.2 0.0097 14.1 0.2 1.1 1 0 0 1 1 1 1 Bovine immunodeficiency virus surface protein (SU) Kei1 PF08552.11 EMD59783.1 - 0.053 13.4 0.4 1.6 8.6 0.2 2.5 2 0 0 2 2 2 0 Inositolphosphorylceramide synthase subunit Kei1 PMT_4TMC PF16192.5 EMD59783.1 - 0.12 11.9 2.7 0.58 9.7 0.3 2.3 2 0 0 2 2 2 0 C-terminal four TMM region of protein-O-mannosyltransferase Meth_synt_2 PF01717.18 EMD59784.1 - 8.4e-14 51.6 0.0 1.5e-13 50.7 0.0 1.4 1 1 0 1 1 1 1 Cobalamin-independent synthase, Catalytic domain Meth_synt_1 PF08267.12 EMD59784.1 - 0.00086 18.9 0.0 0.032 13.7 0.0 2.7 3 0 0 3 3 3 1 Cobalamin-independent synthase, N-terminal domain Kelch_3 PF13415.6 EMD59786.1 - 4e-25 87.5 10.6 4.5e-06 26.8 0.1 6.2 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_4 PF13418.6 EMD59786.1 - 5.9e-24 83.8 10.7 1.7e-12 47.1 0.1 6.3 6 1 0 6 6 6 4 Galactose oxidase, central domain Kelch_6 PF13964.6 EMD59786.1 - 1.2e-15 57.2 5.7 0.00049 20.3 0.0 6.0 5 1 1 6 6 6 3 Kelch motif Kelch_1 PF01344.25 EMD59786.1 - 8.4e-12 44.5 8.2 0.027 14.1 0.7 6.0 5 1 0 5 5 5 4 Kelch motif Kelch_2 PF07646.15 EMD59786.1 - 4.7e-10 39.0 9.1 0.0014 18.6 0.3 6.5 6 1 0 6 6 6 4 Kelch motif Kelch_5 PF13854.6 EMD59786.1 - 2.1e-06 27.6 4.3 2.7 8.1 0.0 5.6 6 0 0 6 6 6 3 Kelch motif p450 PF00067.22 EMD59787.1 - 2.6e-70 237.4 0.0 2.9e-70 237.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF3927 PF13064.6 EMD59787.1 - 0.21 11.6 0.2 0.41 10.7 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3927) Glyco_hydro_16 PF00722.21 EMD59789.1 - 1e-16 60.9 1.1 1.9e-16 60.0 1.1 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 ATPase_gene1 PF09527.10 EMD59789.1 - 0.18 12.0 2.3 2.4 8.4 0.3 2.3 2 0 0 2 2 2 0 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter Glyco_trans_2_3 PF13632.6 EMD59790.1 - 1.8e-53 181.4 0.8 1.8e-53 181.4 0.8 2.4 3 0 0 3 3 3 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.26 EMD59790.1 - 0.00053 19.8 0.0 0.011 15.5 0.0 2.4 2 0 0 2 2 2 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 EMD59790.1 - 0.0084 16.0 0.0 0.014 15.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Utp13 PF08625.11 EMD59790.1 - 0.079 12.9 0.1 0.15 11.9 0.1 1.4 1 0 0 1 1 1 0 Utp13 specific WD40 associated domain P53 PF00870.18 EMD59791.1 - 0.086 12.6 0.5 0.14 11.9 0.5 1.2 1 0 0 1 1 1 0 P53 DNA-binding domain DUF5518 PF17647.1 EMD59791.1 - 0.18 12.0 8.3 0.28 11.4 8.3 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5518) SPX PF03105.19 EMD59791.1 - 0.27 11.1 3.8 0.34 10.8 3.8 1.1 1 0 0 1 1 1 0 SPX domain Hamartin PF04388.12 EMD59791.1 - 3.6 6.1 11.4 4.4 5.8 11.4 1.1 1 0 0 1 1 1 0 Hamartin protein HET PF06985.11 EMD59792.1 - 4.9e-23 82.1 0.0 8.1e-23 81.4 0.0 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Het-C PF07217.11 EMD59793.1 - 8.7e-246 816.8 0.0 1.2e-245 816.4 0.0 1.2 1 0 0 1 1 1 1 Heterokaryon incompatibility protein Het-C Gly-zipper_Omp PF13488.6 EMD59793.1 - 0.027 14.5 12.0 0.054 13.5 12.0 1.5 1 0 0 1 1 1 0 Glycine zipper CTNNBL PF08216.11 EMD59794.1 - 9.4e-37 125.4 0.1 2.1e-36 124.2 0.1 1.6 1 0 0 1 1 1 1 Catenin-beta-like, Arm-motif containing nuclear DUF3361 PF11841.8 EMD59794.1 - 0.017 15.1 1.4 2.8 7.8 0.1 3.4 3 1 1 4 4 4 0 Domain of unknown function (DUF3361) HEAT_2 PF13646.6 EMD59794.1 - 0.028 14.8 1.0 0.14 12.6 0.1 2.7 2 0 0 2 2 2 0 HEAT repeats SIL1 PF16782.5 EMD59794.1 - 0.058 12.6 0.4 1.4 8.1 0.1 2.7 1 1 1 3 3 3 0 Nucleotide exchange factor SIL1 TraC PF07820.12 EMD59794.1 - 0.12 12.7 0.4 0.39 11.1 0.4 1.8 1 0 0 1 1 1 0 TraC-like protein Dus PF01207.17 EMD59795.1 - 4.9e-37 127.7 0.0 2.2e-27 96.0 0.0 2.8 1 1 1 2 2 2 2 Dihydrouridine synthase (Dus) zf-CCCH_4 PF18044.1 EMD59795.1 - 7.6e-05 22.4 11.4 0.0054 16.5 1.3 2.5 2 0 0 2 2 2 2 CCCH-type zinc finger zf_CCCH_4 PF18345.1 EMD59795.1 - 8.1e-05 22.6 8.7 0.064 13.3 1.5 2.7 2 0 0 2 2 2 2 Zinc finger domain zf-CCCH PF00642.24 EMD59795.1 - 0.019 14.9 11.6 0.044 13.7 0.4 2.8 3 0 0 3 3 3 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Gemini_AL2 PF01440.16 EMD59795.1 - 0.1 13.0 0.1 6 7.3 0.1 2.4 2 0 0 2 2 2 0 Geminivirus AL2 protein Bap31 PF05529.12 EMD59796.1 - 1.2e-49 167.6 3.2 1.7e-49 167.2 3.2 1.2 1 0 0 1 1 1 1 Bap31/Bap29 transmembrane region Bap31_Bap29_C PF18035.1 EMD59796.1 - 4.7e-12 45.7 1.2 4.7e-12 45.7 1.2 1.5 2 0 0 2 2 2 1 Bap31/Bap29 cytoplasmic coiled-coil domain Lebercilin PF15619.6 EMD59796.1 - 0.0013 18.5 0.1 0.0018 18.0 0.1 1.3 1 0 0 1 1 1 1 Ciliary protein causing Leber congenital amaurosis disease DivIC PF04977.15 EMD59796.1 - 0.012 15.4 0.3 0.26 11.1 0.0 2.9 3 0 0 3 3 3 0 Septum formation initiator Csm1_N PF18504.1 EMD59796.1 - 0.023 15.0 0.3 0.052 13.9 0.3 1.5 1 0 0 1 1 1 0 Csm1 N-terminal domain Spc7 PF08317.11 EMD59796.1 - 0.045 12.6 0.3 0.06 12.2 0.3 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein She9_MDM33 PF05546.11 EMD59796.1 - 0.082 12.7 1.4 0.17 11.7 0.0 1.9 2 0 0 2 2 2 0 She9 / Mdm33 family Nup54_57_C PF18570.1 EMD59796.1 - 0.12 12.0 1.3 1.1 9.0 0.3 2.2 2 0 0 2 2 2 0 NUP57/Nup54 C-terminal domain Amidase PF01425.21 EMD59797.1 - 4.6e-67 226.9 0.0 4.8e-66 223.6 0.0 1.9 1 1 0 1 1 1 1 Amidase His_Phos_2 PF00328.22 EMD59798.1 - 7.7e-39 134.1 0.0 9.3e-39 133.9 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) DUF2205 PF10224.9 EMD59801.1 - 5.4e-34 116.0 0.5 1.2e-33 115.0 0.5 1.6 1 0 0 1 1 1 1 Short coiled-coil protein Peptidase_M16 PF00675.20 EMD59802.1 - 2e-57 193.4 0.4 1.2e-56 190.9 0.1 2.2 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 EMD59802.1 - 5.1e-38 130.9 0.0 5.1e-37 127.7 0.0 2.2 2 0 0 2 2 2 1 Peptidase M16 inactive domain CybS PF05328.12 EMD59803.1 - 3e-50 169.3 0.0 4.8e-50 168.7 0.0 1.3 1 0 0 1 1 1 1 CybS, succinate dehydrogenase cytochrome B small subunit 14-3-3 PF00244.20 EMD59804.1 - 4e-106 353.5 4.6 4.6e-106 353.3 4.6 1.0 1 0 0 1 1 1 1 14-3-3 protein TPR_12 PF13424.6 EMD59804.1 - 0.0064 16.7 1.4 0.64 10.4 0.1 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TerB PF05099.13 EMD59804.1 - 0.023 14.6 1.2 0.041 13.8 0.3 1.8 2 0 0 2 2 2 0 Tellurite resistance protein TerB Orbi_VP5 PF00901.17 EMD59804.1 - 0.29 9.5 3.8 0.5 8.7 3.8 1.3 1 0 0 1 1 1 0 Orbivirus outer capsid protein VP5 TPR_19 PF14559.6 EMD59804.1 - 1.2 9.7 5.6 0.42 11.1 0.3 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat IATP PF04568.12 EMD59805.1 - 4.2e-21 75.2 0.6 5e-21 74.9 0.6 1.1 1 0 0 1 1 1 1 Mitochondrial ATPase inhibitor, IATP tRNA-synt_1c PF00749.21 EMD59805.1 - 0.071 12.0 0.2 0.093 11.6 0.2 1.1 1 0 0 1 1 1 0 tRNA synthetases class I (E and Q), catalytic domain MIP PF00230.20 EMD59806.1 - 9.8e-49 166.1 15.8 9.8e-49 166.1 15.8 1.6 2 0 0 2 2 2 1 Major intrinsic protein DUF2721 PF11026.8 EMD59807.1 - 0.014 15.3 1.3 0.024 14.5 1.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2721) MgtE PF01769.16 EMD59807.1 - 2.1 8.7 5.5 3.5 8.0 5.5 1.2 1 0 0 1 1 1 0 Divalent cation transporter WD40 PF00400.32 EMD59808.1 - 6.3e-38 128.1 7.5 1.6e-06 28.7 0.0 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD59808.1 - 1.3e-14 54.2 0.3 7.2e-05 23.0 0.0 5.1 2 2 4 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EMD59808.1 - 0.11 11.4 0.0 12 4.7 0.0 2.6 2 1 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein BBS2_Mid PF14783.6 EMD59808.1 - 0.12 12.4 0.1 13 5.8 0.0 2.7 2 1 1 3 3 3 0 Ciliary BBSome complex subunit 2, middle region Nup160 PF11715.8 EMD59808.1 - 0.17 10.5 2.5 9.8 4.7 0.1 2.9 1 1 1 3 3 3 0 Nucleoporin Nup120/160 TRAPP PF04051.16 EMD59809.1 - 1.1e-35 122.5 0.0 1.4e-35 122.2 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component DUF1479 PF07350.12 EMD59811.1 - 2.8e-163 543.6 0.0 3.2e-163 543.3 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1479) PhyH PF05721.13 EMD59811.1 - 0.021 15.1 0.3 7.5 6.7 0.2 2.3 2 0 0 2 2 2 0 Phytanoyl-CoA dioxygenase (PhyH) Glyco_hydro_1 PF00232.18 EMD59812.1 - 1.1e-155 518.5 0.0 1.4e-155 518.2 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 1 Auts2 PF15336.6 EMD59813.1 - 0.061 13.4 1.2 0.076 13.1 1.2 1.1 1 0 0 1 1 1 0 Autism susceptibility gene 2 protein bZIP_1 PF00170.21 EMD59815.1 - 5.2e-05 23.3 9.8 0.0039 17.2 10.0 2.2 1 1 0 1 1 1 1 bZIP transcription factor YabA PF06156.13 EMD59815.1 - 0.0019 18.8 1.3 0.0026 18.4 0.2 1.8 2 0 0 2 2 2 1 Initiation control protein YabA TSC22 PF01166.18 EMD59815.1 - 0.011 16.0 1.7 0.057 13.7 0.3 2.3 1 1 1 2 2 2 0 TSC-22/dip/bun family ABC_tran_CTD PF16326.5 EMD59815.1 - 0.13 12.6 2.6 0.25 11.6 2.6 1.5 1 0 0 1 1 1 0 ABC transporter C-terminal domain HAUS6_N PF14661.6 EMD59815.1 - 0.25 10.9 3.2 0.5 9.9 3.2 1.4 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus bZIP_2 PF07716.15 EMD59815.1 - 0.61 10.2 11.9 1.7 8.8 4.5 2.3 1 1 1 2 2 2 0 Basic region leucine zipper DIOX_N PF14226.6 EMD59817.1 - 2.6e-27 95.9 0.0 1.7e-25 90.0 0.0 2.4 2 0 0 2 2 2 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EMD59817.1 - 3.9e-13 49.7 0.0 7.9e-13 48.8 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily AroM PF07302.11 EMD59819.1 - 0.071 12.5 0.1 0.084 12.3 0.1 1.0 1 0 0 1 1 1 0 AroM protein Senescence PF06911.12 EMD59820.1 - 4e-54 183.7 10.2 6e-54 183.1 10.2 1.3 1 0 0 1 1 1 1 Senescence-associated protein AAA PF00004.29 EMD59821.1 - 1.4e-44 151.7 0.3 3.2e-14 53.5 0.0 6.4 6 0 0 6 6 6 4 ATPase family associated with various cellular activities (AAA) AAA_12 PF13087.6 EMD59821.1 - 2.8e-37 128.3 0.0 6.8e-36 123.8 0.0 3.1 3 0 0 3 3 3 1 AAA domain AAA_11 PF13086.6 EMD59821.1 - 1.2e-26 94.1 44.1 5.5e-24 85.4 0.1 6.5 6 0 0 6 6 6 2 AAA domain AAA_19 PF13245.6 EMD59821.1 - 6.6e-19 68.7 0.3 2.4e-09 37.7 0.0 5.6 4 2 1 5 5 4 3 AAA domain AAA_lid_6 PF17866.1 EMD59821.1 - 6.8e-19 67.8 6.5 6.3e-07 29.5 0.1 4.3 3 0 0 3 3 3 3 AAA lid domain AAA_30 PF13604.6 EMD59821.1 - 7.6e-18 64.9 12.9 2.1e-06 27.6 0.1 6.4 6 0 0 6 6 5 5 AAA domain AAA_5 PF07728.14 EMD59821.1 - 1.4e-15 57.5 1.3 0.00093 19.2 0.0 5.5 4 1 0 4 4 4 4 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 EMD59821.1 - 3.4e-10 39.6 0.5 0.39 10.1 0.0 5.2 5 1 0 5 5 5 3 Magnesium chelatase, subunit ChlI Viral_helicase1 PF01443.18 EMD59821.1 - 6.3e-10 39.2 0.0 1.2 8.9 0.0 6.3 6 0 0 6 6 6 2 Viral (Superfamily 1) RNA helicase AAA_22 PF13401.6 EMD59821.1 - 7.4e-10 39.2 16.8 0.11 12.8 0.0 8.5 6 3 1 7 7 6 3 AAA domain RuvB_N PF05496.12 EMD59821.1 - 1.5e-09 37.8 0.2 0.081 12.7 0.0 4.6 4 0 0 4 4 4 2 Holliday junction DNA helicase RuvB P-loop domain RNA_helicase PF00910.22 EMD59821.1 - 4.2e-08 33.5 0.2 1.3 9.4 0.0 4.7 4 0 0 4 4 4 2 RNA helicase AAA_24 PF13479.6 EMD59821.1 - 5.6e-07 29.5 3.7 0.71 9.6 0.0 5.4 5 1 0 5 5 5 3 AAA domain IstB_IS21 PF01695.17 EMD59821.1 - 9.9e-07 28.7 0.2 3.7 7.2 0.0 4.7 4 0 0 4 4 4 1 IstB-like ATP binding protein ResIII PF04851.15 EMD59821.1 - 3.7e-06 27.0 6.4 0.0039 17.2 0.0 5.1 7 0 0 7 7 5 2 Type III restriction enzyme, res subunit Torsin PF06309.11 EMD59821.1 - 7.8e-05 22.8 0.0 13 5.9 0.0 4.4 4 0 0 4 4 4 0 Torsin AAA_18 PF13238.6 EMD59821.1 - 0.00012 22.7 11.6 2.4 8.7 0.0 5.5 5 0 0 5 5 4 1 AAA domain AAA_7 PF12775.7 EMD59821.1 - 0.00012 21.6 0.6 14 5.2 0.0 4.3 4 0 0 4 4 4 0 P-loop containing dynein motor region PhoH PF02562.16 EMD59821.1 - 0.00044 19.8 1.2 1 8.8 0.0 4.3 4 0 0 4 4 4 1 PhoH-like protein DUF2075 PF09848.9 EMD59821.1 - 0.0011 18.3 0.0 0.0011 18.3 0.0 6.0 6 1 1 7 7 6 1 Uncharacterized conserved protein (DUF2075) AAA_16 PF13191.6 EMD59821.1 - 0.0036 17.7 23.5 0.68 10.3 0.1 6.6 6 1 0 6 6 4 2 AAA ATPase domain SRP54 PF00448.22 EMD59821.1 - 0.019 14.6 5.7 0.2 11.2 0.1 3.7 4 0 0 4 4 4 0 SRP54-type protein, GTPase domain Rad17 PF03215.15 EMD59821.1 - 0.021 14.8 0.1 3.3 7.6 0.0 3.3 4 1 0 4 4 2 0 Rad17 P-loop domain DEAD PF00270.29 EMD59821.1 - 0.022 14.5 1.1 1.3 8.7 0.1 3.7 4 1 1 5 5 4 0 DEAD/DEAH box helicase AAA_29 PF13555.6 EMD59821.1 - 0.033 13.9 0.5 68 3.3 0.0 4.2 4 0 0 4 4 4 0 P-loop containing region of AAA domain AAA_25 PF13481.6 EMD59821.1 - 0.034 13.7 7.6 3.3 7.2 0.0 5.0 5 0 0 5 5 5 0 AAA domain TsaE PF02367.17 EMD59821.1 - 0.18 11.8 1.9 45 4.0 0.0 3.9 4 0 0 4 4 4 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 EMD59821.1 - 0.51 10.2 5.5 29 4.5 0.0 4.8 5 0 0 5 5 5 0 NACHT domain NTPase_1 PF03266.15 EMD59821.1 - 0.87 9.5 3.9 44 3.9 0.0 4.1 4 0 0 4 4 4 0 NTPase CbiA PF01656.23 EMD59821.1 - 1.1 9.3 4.5 13 5.9 0.1 4.1 4 0 0 4 4 4 0 CobQ/CobB/MinD/ParA nucleotide binding domain ABC_tran PF00005.27 EMD59821.1 - 1.3 9.5 13.9 5 7.6 0.0 5.3 5 0 0 5 5 4 0 ABC transporter SBDS PF01172.18 EMD59823.1 - 1.3e-20 73.2 0.2 1.6e-20 73.0 0.2 1.1 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein RhoGEF PF00621.20 EMD59824.1 - 9.9e-29 100.9 0.1 1.8e-28 100.0 0.1 1.5 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.29 EMD59824.1 - 0.015 15.8 0.0 0.066 13.7 0.0 2.1 3 0 0 3 3 3 0 PH domain Nas2_N PF18265.1 EMD59825.1 - 2.5e-30 104.2 0.1 3.5e-30 103.7 0.1 1.2 1 0 0 1 1 1 1 Nas2 N_terminal domain PDZ_6 PF17820.1 EMD59825.1 - 2.6e-11 43.2 0.1 8.6e-11 41.5 0.0 1.9 2 0 0 2 2 2 1 PDZ domain PDZ PF00595.24 EMD59825.1 - 2.3e-06 27.9 0.0 4.4e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 EMD59825.1 - 4.2e-06 27.0 0.0 7.1e-06 26.3 0.0 1.5 1 0 0 1 1 1 1 PDZ domain GRASP55_65 PF04495.14 EMD59825.1 - 0.001 19.4 0.0 0.0046 17.3 0.0 2.2 1 1 0 1 1 1 1 GRASP55/65 PDZ-like domain Ras PF00071.22 EMD59826.1 - 1.6e-48 164.4 0.0 2e-48 164.1 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMD59826.1 - 1e-28 99.9 0.0 2.5e-28 98.7 0.0 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMD59826.1 - 5.6e-10 38.9 0.0 7.6e-10 38.5 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EMD59826.1 - 0.00084 19.4 0.0 0.0017 18.5 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase RNA_helicase PF00910.22 EMD59826.1 - 0.00097 19.5 0.1 0.006 17.0 0.1 2.1 1 1 0 1 1 1 1 RNA helicase Gtr1_RagA PF04670.12 EMD59826.1 - 0.0027 17.1 0.0 0.0036 16.7 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.20 EMD59826.1 - 0.02 14.1 1.4 1.5 7.9 0.1 2.5 2 1 1 3 3 3 0 G-protein alpha subunit Pox_A32 PF04665.12 EMD59826.1 - 0.021 14.3 0.1 0.042 13.3 0.1 1.4 1 0 0 1 1 1 0 Poxvirus A32 protein AAA_7 PF12775.7 EMD59826.1 - 0.034 13.6 0.0 0.059 12.9 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_24 PF13479.6 EMD59826.1 - 0.063 13.0 0.1 0.1 12.3 0.1 1.4 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 EMD59826.1 - 0.073 13.1 0.0 0.16 11.9 0.1 1.6 2 0 0 2 2 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_16 PF13191.6 EMD59826.1 - 0.083 13.3 0.0 0.15 12.4 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain ArgoMid PF16487.5 EMD59826.1 - 0.096 13.0 0.0 0.19 12.0 0.0 1.5 1 0 0 1 1 1 0 Mid domain of argonaute RsgA_GTPase PF03193.16 EMD59826.1 - 0.12 12.2 0.1 8.1 6.3 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase AAA_33 PF13671.6 EMD59826.1 - 0.14 12.3 1.0 0.22 11.7 0.2 1.7 2 0 0 2 2 2 0 AAA domain Zn_clus PF00172.18 EMD59827.1 - 5.7e-09 35.9 9.5 9.2e-09 35.3 9.5 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EMD59827.1 - 1.7e-07 30.6 0.0 3.1e-07 29.7 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain PDZ_assoc PF10600.9 EMD59827.1 - 0.09 13.6 1.7 0.28 12.0 1.7 1.8 1 0 0 1 1 1 0 PDZ-associated domain of NMDA receptors Epimerase PF01370.21 EMD59828.1 - 6.1e-36 124.1 0.0 1.3e-33 116.5 0.0 2.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EMD59828.1 - 2e-32 112.9 0.0 1.2e-24 87.4 0.0 2.7 2 1 0 2 2 2 2 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 EMD59828.1 - 5.9e-05 22.3 0.0 0.0083 15.3 0.0 2.9 3 0 0 3 3 3 1 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.19 EMD59828.1 - 0.00019 20.6 0.1 0.17 10.9 0.0 2.4 2 0 0 2 2 2 2 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 EMD59828.1 - 0.00019 20.7 0.0 0.0012 18.0 0.0 2.1 2 1 1 3 3 3 1 Male sterility protein adh_short PF00106.25 EMD59828.1 - 0.047 13.1 0.0 0.098 12.1 0.0 1.6 1 0 0 1 1 1 0 short chain dehydrogenase Glyco_hydro_114 PF03537.13 EMD59829.1 - 1.1e-83 280.1 0.0 1.4e-83 279.8 0.0 1.1 1 0 0 1 1 1 1 Glycoside-hydrolase family GH114 SNARE PF05739.19 EMD59829.1 - 0.16 12.0 0.5 0.32 11.0 0.5 1.4 1 0 0 1 1 1 0 SNARE domain Polysacc_deac_1 PF01522.21 EMD59830.1 - 0.028 14.3 0.0 0.065 13.1 0.0 1.6 1 0 0 1 1 1 0 Polysaccharide deacetylase Glyco_trans_1_4 PF13692.6 EMD59831.1 - 6.3e-11 42.8 0.0 1.6e-10 41.6 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glycos_transf_1 PF00534.20 EMD59831.1 - 5e-08 32.7 0.0 1.1e-07 31.5 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 DUF3492 PF11997.8 EMD59831.1 - 0.00036 20.4 0.0 0.0033 17.2 0.0 2.3 1 1 0 1 1 1 1 Domain of unknown function (DUF3492) Orthopox_35kD PF02250.15 EMD59831.1 - 0.0053 16.5 0.0 0.42 10.3 0.0 2.3 2 0 0 2 2 2 1 35kD major secreted virus protein zf-C2H2_aberr PF17017.5 EMD59832.1 - 0.00036 20.7 2.7 0.099 12.8 0.2 2.4 2 0 0 2 2 2 2 Aberrant zinc-finger zf-C2H2 PF00096.26 EMD59832.1 - 0.001 19.4 13.2 0.057 13.9 1.5 3.3 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMD59832.1 - 0.0019 18.9 12.6 0.053 14.4 0.6 3.7 3 0 0 3 3 3 2 C2H2-type zinc finger ADC PF06314.11 EMD59832.1 - 0.03 13.9 0.0 0.059 12.9 0.0 1.4 1 0 0 1 1 1 0 Acetoacetate decarboxylase (ADC) zf-H2C2_2 PF13465.6 EMD59832.1 - 0.038 14.4 0.5 0.038 14.4 0.5 2.9 3 0 0 3 3 3 0 Zinc-finger double domain zf-C2H2_jaz PF12171.8 EMD59832.1 - 0.89 9.9 5.8 3 8.2 0.1 3.1 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding MFS_1 PF07690.16 EMD59834.1 - 1.4e-31 109.8 58.8 3.7e-30 105.1 45.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EMD59834.1 - 2.6e-06 26.6 39.0 0.0025 16.8 15.9 2.3 2 0 0 2 2 2 2 Sugar (and other) transporter LPD30 PF18850.1 EMD59834.1 - 0.21 11.3 0.2 0.45 10.3 0.2 1.4 1 0 0 1 1 1 0 Large polyvalent protein associated domain 30 Ank_2 PF12796.7 EMD59836.1 - 3.7e-70 232.5 2.6 7.8e-12 45.6 0.0 9.7 3 3 8 11 11 11 10 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMD59836.1 - 1e-59 198.2 9.4 1.1e-08 35.4 0.0 14.9 9 4 8 17 17 17 13 Ankyrin repeats (many copies) Ank_5 PF13857.6 EMD59836.1 - 7.5e-50 166.4 15.9 1.3e-07 31.7 0.0 15.1 7 5 9 16 16 16 13 Ankyrin repeats (many copies) Ank PF00023.30 EMD59836.1 - 3.8e-49 163.1 18.6 3.4e-05 24.1 0.2 16.5 18 0 0 18 18 18 9 Ankyrin repeat Ank_3 PF13606.6 EMD59836.1 - 1.7e-46 150.8 6.7 0.00018 21.7 0.0 17.5 19 0 0 19 19 19 10 Ankyrin repeat DDE_1 PF03184.19 EMD59841.1 - 2.5e-09 37.0 0.0 2.9e-09 36.8 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease RBR PF17208.3 EMD59842.1 - 0.062 14.0 7.9 0.072 13.8 7.9 1.3 1 1 0 1 1 1 0 RNA binding Region Clr2_transil PF16761.5 EMD59845.1 - 1.2e-19 70.9 2.1 2.3e-19 70.0 1.0 2.2 3 0 0 3 3 3 1 Transcription-silencing protein, cryptic loci regulator Clr2 Clr2 PF10383.9 EMD59845.1 - 2.9e-17 63.8 0.0 5.7e-15 56.4 0.0 3.0 1 1 0 1 1 1 1 Transcription-silencing protein Clr2 Tropomyosin PF00261.20 EMD59846.1 - 0.00081 18.8 13.0 0.00081 18.8 13.0 2.4 2 1 1 3 3 3 1 Tropomyosin Fib_alpha PF08702.10 EMD59846.1 - 0.0043 17.2 2.6 0.0043 17.2 2.6 3.4 2 1 0 3 3 3 1 Fibrinogen alpha/beta chain family Med9 PF07544.13 EMD59846.1 - 0.039 14.0 0.2 0.039 14.0 0.2 3.3 3 1 0 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 Fez1 PF06818.15 EMD59846.1 - 0.082 13.3 21.8 0.082 13.4 13.7 2.5 1 1 1 2 2 2 0 Fez1 GAS PF13851.6 EMD59846.1 - 0.17 11.2 26.1 0.11 11.8 11.8 3.1 2 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding Goodbye PF17109.5 EMD59846.1 - 0.18 12.3 5.0 2.8 8.4 0.4 2.8 2 0 0 2 2 2 0 fungal STAND N-terminal Goodbye domain Phage_GP20 PF06810.11 EMD59846.1 - 1.2 8.9 16.1 0.33 10.8 2.6 2.9 2 1 0 3 3 3 0 Phage minor structural protein GP20 V_ATPase_I PF01496.19 EMD59846.1 - 1.4 6.7 8.3 2.2 6.1 8.3 1.4 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TMF_TATA_bd PF12325.8 EMD59846.1 - 2.3 8.4 22.9 0.77 10.0 5.7 3.4 2 2 1 3 3 3 0 TATA element modulatory factor 1 TATA binding SKA2 PF16740.5 EMD59846.1 - 8.3 6.2 15.3 0.19 11.5 3.2 3.1 3 1 0 3 3 3 0 Spindle and kinetochore-associated protein 2 Ank_4 PF13637.6 EMD59849.1 - 6.5e-30 103.1 2.9 2.4e-08 34.3 0.0 7.2 2 2 6 8 8 8 5 Ankyrin repeats (many copies) Ank PF00023.30 EMD59849.1 - 7.7e-30 102.0 4.2 5.4e-07 29.8 0.0 7.6 8 0 0 8 8 8 5 Ankyrin repeat Ank_5 PF13857.6 EMD59849.1 - 9.8e-30 102.2 6.6 9.6e-10 38.5 0.3 6.3 7 0 0 7 7 7 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 EMD59849.1 - 7.4e-28 97.0 4.8 1.6e-11 44.6 1.0 5.2 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EMD59849.1 - 6.4e-22 75.3 5.3 3.9e-06 26.8 0.0 8.5 9 2 0 9 9 9 3 Ankyrin repeat Peptidase_M16 PF00675.20 EMD59849.1 - 0.03 14.3 0.0 0.26 11.3 0.0 2.3 2 0 0 2 2 2 0 Insulinase (Peptidase family M16) DUF4174 PF13778.6 EMD59850.1 - 0.039 14.4 1.5 0.07 13.6 1.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4174) Golgin_A5 PF09787.9 EMD59850.1 - 0.67 9.4 8.6 0.034 13.6 3.1 1.6 2 0 0 2 2 2 0 Golgin subfamily A member 5 G0-G1_switch_2 PF15103.6 EMD59850.1 - 3.9 8.0 6.0 0.87 10.0 0.9 2.0 2 0 0 2 2 2 0 G0/G1 switch protein 2 Integrase_H2C2 PF17921.1 EMD59851.1 - 6.8e-08 32.5 0.0 1.1e-07 31.9 0.0 1.3 1 0 0 1 1 1 1 Integrase zinc binding domain Chromo PF00385.24 EMD59852.1 - 3e-05 23.9 0.5 5e-05 23.1 0.5 1.4 1 1 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Chromo_shadow PF01393.19 EMD59852.1 - 0.12 12.5 0.0 0.17 12.0 0.0 1.3 1 0 0 1 1 1 0 Chromo shadow domain DUF1957 PF09210.11 EMD59853.1 - 0.026 14.9 1.0 0.029 14.8 1.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1957) Amidase PF01425.21 EMD59855.1 - 9.2e-82 275.4 0.0 2.3e-81 274.1 0.0 1.6 1 1 0 1 1 1 1 Amidase RAD51_interact PF15696.5 EMD59855.1 - 0.047 13.8 0.4 0.11 12.6 0.4 1.6 1 0 0 1 1 1 0 RAD51 interacting motif MMtag PF10159.9 EMD59856.1 - 1.2e-31 108.8 4.5 1.2e-31 108.8 4.5 3.3 2 1 0 2 2 2 1 Multiple myeloma tumor-associated Med6 PF04934.14 EMD59857.1 - 2e-12 47.0 0.0 3.4e-12 46.3 0.0 1.3 1 0 0 1 1 1 1 MED6 mediator sub complex component Pkinase PF00069.25 EMD59858.1 - 1.4e-56 191.8 0.0 1.9e-56 191.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD59858.1 - 1.7e-32 112.7 0.0 2.6e-32 112.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMD59858.1 - 1e-12 48.0 0.0 1.9e-09 37.3 0.0 2.2 2 0 0 2 2 2 2 Kinase-like APH PF01636.23 EMD59858.1 - 0.0028 17.6 0.0 0.0052 16.7 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 EMD59858.1 - 0.013 14.8 0.0 0.023 14.1 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Hydrolase PF00702.26 EMD59859.1 - 3.6e-06 27.4 0.0 5.1e-06 26.9 0.0 1.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EMD59859.1 - 1.8e-05 24.9 0.0 3.3e-05 24.0 0.0 1.5 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EMD59859.1 - 0.063 13.3 0.0 0.15 12.2 0.0 1.6 1 0 0 1 1 1 0 HAD-hyrolase-like Abhydrolase_6 PF12697.7 EMD59860.1 - 4e-14 53.8 0.0 4.9e-14 53.5 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Longin PF13774.6 EMD59861.1 - 3.4e-26 91.1 0.5 6.1e-26 90.3 0.2 1.6 2 0 0 2 2 2 1 Regulated-SNARE-like domain Synaptobrevin PF00957.21 EMD59861.1 - 4.2e-15 55.3 0.2 1.2e-14 53.8 0.0 1.8 2 0 0 2 2 2 1 Synaptobrevin SLM4 PF16818.5 EMD59861.1 - 0.12 12.4 0.1 1.2 9.1 0.0 2.1 2 0 0 2 2 2 0 Protein SLM4 DUF1664 PF07889.12 EMD59861.1 - 0.34 10.9 2.0 1.3 9.0 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) ASXH PF13919.6 EMD59862.1 - 1.4e-26 93.1 0.2 3.4e-26 91.9 0.2 1.7 1 0 0 1 1 1 1 Asx homology domain Macoilin PF09726.9 EMD59862.1 - 0.71 8.4 11.3 0.79 8.2 11.3 1.1 1 0 0 1 1 1 0 Macoilin family Pec_lyase_C PF00544.19 EMD59863.1 - 5.8e-40 137.1 14.8 5.8e-40 137.1 14.8 1.4 1 1 0 1 1 1 1 Pectate lyase CBM_21 PF03370.13 EMD59863.1 - 0.088 13.0 1.2 0.24 11.6 1.2 1.7 1 1 0 1 1 1 0 Carbohydrate/starch-binding module (family 21) Mito_carr PF00153.27 EMD59865.1 - 1.7e-66 220.2 6.6 2.8e-24 84.9 0.2 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF4748 PF15932.5 EMD59865.1 - 0.031 14.0 0.8 0.1 12.3 0.8 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4748) Peptidase_S41 PF03572.18 EMD59866.1 - 5.7e-08 32.5 0.0 1.7e-07 31.0 0.0 1.7 1 1 0 1 1 1 1 Peptidase family S41 AtuA PF07287.11 EMD59866.1 - 0.022 13.5 0.0 0.077 11.7 0.0 1.7 2 0 0 2 2 2 0 Acyclic terpene utilisation family protein AtuA VTC PF09359.10 EMD59868.1 - 6.8e-93 311.0 1.2 1.4e-92 310.0 1.2 1.6 1 0 0 1 1 1 1 VTC domain CENP-I PF07778.11 EMD59868.1 - 2.3e-38 132.2 0.0 6.1e-37 127.5 0.0 2.4 1 1 0 1 1 1 1 Mis6 DUF202 PF02656.15 EMD59868.1 - 1.5e-12 47.7 1.7 5.1e-12 46.0 1.7 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF202) SPX PF03105.19 EMD59868.1 - 5.9e-06 26.4 19.1 1.6e-05 25.0 2.4 3.4 2 1 1 3 3 3 2 SPX domain SPT_ssu-like PF11779.8 EMD59870.1 - 5e-24 83.7 5.1 5e-24 83.7 5.1 1.6 2 0 0 2 2 2 1 Small subunit of serine palmitoyltransferase-like WzyE PF06899.11 EMD59870.1 - 0.0018 17.3 1.8 0.0021 17.1 1.8 1.0 1 0 0 1 1 1 1 WzyE protein, O-antigen assembly polymerase FtsX PF02687.21 EMD59870.1 - 0.096 13.2 3.1 0.15 12.6 3.1 1.3 1 0 0 1 1 1 0 FtsX-like permease family DUF2070 PF09843.9 EMD59870.1 - 0.89 7.8 3.7 1 7.5 3.7 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) RF-1 PF00472.20 EMD59871.1 - 5.4e-25 87.6 3.6 7.5e-25 87.1 3.6 1.2 1 0 0 1 1 1 1 RF-1 domain AP3D1 PF06375.11 EMD59871.1 - 0.0042 17.3 6.2 0.0045 17.2 6.2 1.2 1 0 0 1 1 1 1 AP-3 complex subunit delta-1 DUF816 PF05674.12 EMD59872.1 - 0.14 12.0 0.0 0.15 12.0 0.0 1.1 1 0 0 1 1 1 0 Baculovirus protein of unknown function (DUF816) DUF2043 PF09740.9 EMD59874.1 - 0.028 15.1 0.0 0.07 13.8 0.0 1.7 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2043) FAD_binding_4 PF01565.23 EMD59875.1 - 8.8e-24 83.8 6.4 1.4e-23 83.2 5.8 1.7 2 0 0 2 2 2 1 FAD binding domain Chitin_bind_1 PF00187.19 EMD59875.1 - 7.4e-05 23.1 23.1 0.00017 22.0 23.1 1.7 1 0 0 1 1 1 1 Chitin recognition protein HD PF01966.22 EMD59877.1 - 0.00015 21.9 0.5 0.00069 19.8 0.1 2.2 2 1 0 2 2 2 1 HD domain INTS5_N PF14837.6 EMD59877.1 - 0.11 12.1 0.1 0.18 11.4 0.1 1.3 1 0 0 1 1 1 0 Integrator complex subunit 5 N-terminus Pex16 PF08610.10 EMD59878.1 - 1.3e-140 468.2 0.6 1.5e-140 468.0 0.6 1.0 1 0 0 1 1 1 1 Peroxisomal membrane protein (Pex16) MitMem_reg PF13012.6 EMD59879.1 - 3.2e-37 127.4 0.0 5.4e-37 126.6 0.0 1.4 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function JAB PF01398.21 EMD59879.1 - 4e-30 104.2 0.0 7.9e-30 103.3 0.0 1.5 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease tRNA_bind_2 PF13725.6 EMD59879.1 - 0.019 14.7 4.1 0.028 14.1 4.1 1.2 1 0 0 1 1 1 0 Possible tRNA binding domain Connexin PF00029.19 EMD59879.1 - 0.32 10.7 1.4 0.47 10.2 1.4 1.2 1 0 0 1 1 1 0 Connexin FAM176 PF14851.6 EMD59880.1 - 0.0087 15.7 1.0 0.25 11.0 0.5 2.2 2 0 0 2 2 2 1 FAM176 family SWIM PF04434.17 EMD59880.1 - 0.036 13.8 5.6 0.061 13.0 0.2 2.3 2 0 0 2 2 2 0 SWIM zinc finger BIRC6 PF12356.8 EMD59880.1 - 0.053 12.9 1.2 1.2 8.6 1.3 2.4 2 0 0 2 2 2 0 Baculoviral IAP repeat-containing protein 6 PBP1_TM PF14812.6 EMD59880.1 - 9.3 6.7 13.8 1.8 9.0 4.3 2.4 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal SWIRM PF04433.17 EMD59882.1 - 1e-12 48.2 0.0 2.3e-12 47.1 0.0 1.6 1 0 0 1 1 1 1 SWIRM domain CDC50 PF03381.15 EMD59883.1 - 2.3e-99 332.5 0.0 2.8e-99 332.2 0.0 1.1 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family Glyco_hydro_17 PF00332.18 EMD59884.1 - 1.7e-07 31.2 0.8 2.7e-07 30.5 0.8 1.5 1 1 0 1 1 1 1 Glycosyl hydrolases family 17 ParG PF09274.10 EMD59884.1 - 0.2 11.8 0.0 0.45 10.7 0.0 1.5 1 0 0 1 1 1 0 ParG Proteasome PF00227.26 EMD59885.1 - 1.6e-54 184.3 0.1 2.1e-54 183.9 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EMD59885.1 - 1.9e-12 46.6 0.0 3.6e-12 45.7 0.0 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature DUF3536 PF12055.8 EMD59885.1 - 0.11 11.8 0.0 0.19 11.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3536) QCR10 PF09796.9 EMD59886.1 - 8.4e-29 99.4 1.1 1.1e-28 99.1 1.1 1.1 1 0 0 1 1 1 1 Ubiquinol-cytochrome-c reductase complex subunit (QCR10) Ank_4 PF13637.6 EMD59887.1 - 9.4e-23 80.3 1.3 8.3e-09 35.8 0.0 2.9 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 EMD59887.1 - 2e-18 66.7 2.3 9.2e-11 42.2 0.2 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 EMD59887.1 - 4.9e-14 52.0 5.5 0.0005 20.4 0.1 4.1 4 0 0 4 4 4 3 Ankyrin repeat Ank_3 PF13606.6 EMD59887.1 - 8.9e-09 34.9 0.2 0.16 12.6 0.0 4.0 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 EMD59887.1 - 1e-05 25.7 1.3 0.0024 18.2 0.3 2.7 1 1 2 3 3 3 2 Ankyrin repeats (many copies) DUF1843 PF08898.10 EMD59887.1 - 0.022 15.3 4.2 16 6.1 0.1 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF1843) Pneumo_ncap PF03246.13 EMD59887.1 - 0.023 13.5 0.1 5.9 5.5 0.0 2.5 1 1 1 2 2 2 0 Pneumovirus nucleocapsid protein DUF892 PF05974.12 EMD59887.1 - 0.064 13.3 1.4 42 4.1 0.1 2.9 1 1 2 3 3 3 0 Domain of unknown function (DUF892) CUE PF02845.16 EMD59887.1 - 0.095 12.4 0.6 6.2 6.6 0.0 2.8 3 0 0 3 3 3 0 CUE domain Ank_4 PF13637.6 EMD59888.1 - 9.4e-13 48.4 0.1 8.1e-06 26.3 0.0 2.0 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 EMD59888.1 - 7.3e-11 42.0 0.5 0.00025 21.3 0.2 3.0 3 0 0 3 3 3 2 Ankyrin repeat Ank_2 PF12796.7 EMD59888.1 - 3.6e-08 33.9 0.1 5.2e-08 33.4 0.1 1.3 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EMD59888.1 - 6.4e-05 23.1 0.0 0.47 11.2 0.0 2.6 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 EMD59888.1 - 0.0079 16.5 0.2 0.086 13.2 0.2 2.0 1 1 0 1 1 1 1 Ankyrin repeats (many copies) YajC PF02699.15 EMD59888.1 - 0.085 12.7 0.7 0.6 10.0 0.1 1.9 1 1 1 2 2 2 0 Preprotein translocase subunit CholecysA-Rec_N PF09193.10 EMD59888.1 - 0.16 12.0 0.1 1.6 8.8 0.1 2.1 2 0 0 2 2 2 0 Cholecystokinin A receptor, N-terminal Ank_2 PF12796.7 EMD59889.1 - 3e-13 50.2 0.2 1e-12 48.4 0.1 2.1 2 1 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMD59889.1 - 6.3e-13 48.9 0.3 9.4e-08 32.5 0.1 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMD59889.1 - 3.7e-10 39.2 0.4 0.024 15.1 0.0 4.0 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.6 EMD59889.1 - 1.1e-09 38.4 0.3 0.012 16.0 0.0 4.4 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 EMD59889.1 - 3.1e-08 33.7 0.4 0.28 11.7 0.1 3.7 3 0 0 3 3 3 3 Ankyrin repeat Cation_efflux PF01545.21 EMD59890.1 - 5.4e-25 88.3 14.7 6.7e-25 88.0 14.7 1.1 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 EMD59890.1 - 2.4e-08 34.0 0.3 4.7e-08 33.1 0.3 1.4 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter YscJ_FliF PF01514.17 EMD59890.1 - 0.14 11.8 0.0 0.32 10.6 0.0 1.5 1 0 0 1 1 1 0 Secretory protein of YscJ/FliF family Zip PF02535.22 EMD59892.1 - 1.7e-54 185.3 1.9 3.9e-54 184.1 1.9 1.5 1 1 0 1 1 1 1 ZIP Zinc transporter DUF3185 PF11381.8 EMD59892.1 - 0.098 12.7 2.8 0.37 10.8 2.7 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF3185) ATP-synt_Eps PF04627.13 EMD59893.1 - 0.0064 16.4 0.4 0.027 14.4 0.0 2.1 2 0 0 2 2 2 1 Mitochondrial ATP synthase epsilon chain Glyoxalase PF00903.25 EMD59894.1 - 1.7e-22 80.0 0.2 2.1e-16 60.3 0.0 2.3 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 EMD59894.1 - 1.4e-12 47.8 0.1 1.1e-05 25.6 0.0 2.4 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_5 PF14696.6 EMD59894.1 - 7.6e-06 26.2 0.3 0.00076 19.7 0.4 2.9 2 1 0 2 2 2 1 Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal Glyoxalase_3 PF13468.6 EMD59894.1 - 5.3e-05 23.4 0.2 0.44 10.6 0.0 3.0 2 1 0 2 2 2 2 Glyoxalase-like domain Gemini_C4 PF01492.17 EMD59894.1 - 0.085 12.8 0.0 0.18 11.7 0.0 1.5 1 0 0 1 1 1 0 Geminivirus C4 protein Zn_clus PF00172.18 EMD59895.1 - 3e-05 24.1 8.3 7.7e-05 22.7 8.3 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain NIF PF03031.18 EMD59896.1 - 1.1e-20 74.0 0.0 1.5e-20 73.6 0.0 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase RRP36 PF06102.12 EMD59897.1 - 1.4e-53 181.3 35.1 1.4e-53 181.3 35.1 2.6 2 1 0 2 2 2 1 rRNA biogenesis protein RRP36 TFR_dimer PF04253.15 EMD59899.1 - 9.7e-23 80.6 0.0 1.7e-22 79.8 0.0 1.4 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.17 EMD59899.1 - 2.4e-22 79.6 0.0 4.4e-22 78.7 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 EMD59899.1 - 4.6e-10 39.4 0.1 1.3e-09 38.0 0.1 1.7 1 0 0 1 1 1 1 PA domain BTB PF00651.31 EMD59900.1 - 7.8e-08 32.5 0.0 1.4e-07 31.7 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain Abp2 PF09441.10 EMD59905.1 - 1.3e-83 279.2 0.0 1.9e-83 278.7 0.0 1.2 1 0 0 1 1 1 1 ARS binding protein 2 DUF5572 PF17733.1 EMD59906.1 - 2.5e-24 84.9 1.9 5.1e-24 83.8 1.9 1.6 1 0 0 1 1 1 1 Family of unknown function (DUF5572) LSM14 PF12701.7 EMD59907.1 - 7.1e-30 102.9 0.1 1.2e-29 102.2 0.1 1.4 1 0 0 1 1 1 1 Scd6-like Sm domain FDF PF09532.10 EMD59907.1 - 5.3e-19 69.0 1.7 2e-18 67.2 1.7 2.0 1 0 0 1 1 1 1 FDF domain SM-ATX PF14438.6 EMD59907.1 - 1.8e-05 24.7 0.0 3.8e-05 23.8 0.0 1.6 1 0 0 1 1 1 1 Ataxin 2 SM domain DUF1067 PF06362.11 EMD59907.1 - 0.0063 17.3 1.0 0.018 15.8 1.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1067) LSM PF01423.22 EMD59907.1 - 0.23 11.2 0.0 0.37 10.5 0.0 1.3 1 0 0 1 1 1 0 LSM domain API5 PF05918.11 EMD59907.1 - 3.1 6.5 18.9 1.7 7.4 2.7 2.2 2 0 0 2 2 2 0 Apoptosis inhibitory protein 5 (API5) HET PF06985.11 EMD59908.1 - 4.8e-11 43.2 9.5 8.3e-10 39.2 0.6 2.8 2 1 1 3 3 3 2 Heterokaryon incompatibility protein (HET) NACHT PF05729.12 EMD59908.1 - 7.6e-09 35.7 0.0 1.4e-08 34.9 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 EMD59908.1 - 7.3e-05 23.2 0.0 0.00015 22.2 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain NB-ARC PF00931.22 EMD59908.1 - 0.0014 17.9 0.2 0.03 13.5 0.0 2.7 2 1 1 3 3 3 1 NB-ARC domain AAA_14 PF13173.6 EMD59908.1 - 0.011 15.8 0.0 0.32 11.0 0.0 2.4 1 1 0 1 1 1 0 AAA domain AAA PF00004.29 EMD59908.1 - 0.011 16.2 0.0 0.059 13.8 0.0 2.4 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 EMD59908.1 - 0.013 15.3 0.0 0.03 14.1 0.0 1.6 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 EMD59908.1 - 0.024 15.0 0.0 0.097 13.1 0.0 2.2 1 1 0 1 1 1 0 RNA helicase Parvo_NS1 PF01057.17 EMD59908.1 - 0.063 12.4 0.1 0.24 10.4 0.0 1.9 1 1 1 2 2 2 0 Parvovirus non-structural protein NS1 ATPase_2 PF01637.18 EMD59908.1 - 0.08 12.8 0.0 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_22 PF13401.6 EMD59908.1 - 0.15 12.3 0.1 0.71 10.2 0.1 2.2 1 1 0 1 1 1 0 AAA domain Mito_carr PF00153.27 EMD59909.1 - 7.2e-51 170.1 4.1 4.6e-16 58.5 0.2 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Transp_cyt_pur PF02133.15 EMD59910.1 - 1.4e-29 103.2 37.2 2e-29 102.7 36.6 1.5 1 1 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin COX7a PF02238.15 EMD59910.1 - 1.6 9.2 4.8 0.92 10.0 0.4 3.0 2 0 0 2 2 2 0 Cytochrome c oxidase subunit VII MFS_1 PF07690.16 EMD59911.1 - 3.6e-42 144.5 27.9 3.6e-42 144.5 27.9 1.7 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EMD59911.1 - 3.5e-08 32.8 9.8 3.5e-08 32.8 9.8 2.9 2 2 0 3 3 3 1 Sugar (and other) transporter MFS_3 PF05977.13 EMD59911.1 - 0.00087 17.8 2.0 0.0018 16.8 2.0 1.4 1 0 0 1 1 1 1 Transmembrane secretion effector Anoctamin PF04547.12 EMD59911.1 - 0.0013 17.7 0.2 0.0025 16.7 0.2 1.5 1 1 0 1 1 1 1 Calcium-activated chloride channel DUF3684 PF12449.8 EMD59912.1 - 0 1185.9 0.0 0 1185.6 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3684) HATPase_c_3 PF13589.6 EMD59912.1 - 0.0034 17.2 0.0 0.012 15.4 0.0 1.9 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase WLM PF08325.10 EMD59912.1 - 0.024 14.7 0.5 0.024 14.7 0.5 1.7 2 0 0 2 2 2 0 WLM domain ThrE_2 PF12821.7 EMD59912.1 - 0.14 12.3 0.0 0.31 11.2 0.0 1.5 1 0 0 1 1 1 0 Threonine/Serine exporter, ThrE TRAPPC9-Trs120 PF08626.11 EMD59913.1 - 0 1460.2 0.0 0 1460.0 0.0 1.0 1 0 0 1 1 1 1 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit 6PF2K PF01591.18 EMD59914.1 - 9.2e-74 247.5 0.2 3.8e-52 176.8 0.1 2.2 2 0 0 2 2 2 2 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 EMD59914.1 - 6.2e-30 104.3 0.2 8.5e-23 81.1 0.0 2.9 4 0 0 4 4 4 2 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 EMD59914.1 - 0.013 15.6 0.0 0.39 10.9 0.0 2.4 2 0 0 2 2 2 0 AAA domain KTI12 PF08433.10 EMD59914.1 - 0.03 13.8 0.0 0.057 12.9 0.0 1.4 1 0 0 1 1 1 0 Chromatin associated protein KTI12 DUF1493 PF07377.12 EMD59914.1 - 0.12 12.8 0.0 1.1 9.7 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1493) DUF202 PF02656.15 EMD59915.1 - 0.0031 17.9 7.9 0.017 15.6 7.9 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF202) Cauli_VI PF01693.16 EMD59916.1 - 4.3e-34 116.6 10.3 5.9e-18 64.9 1.5 2.5 2 0 0 2 2 2 2 Caulimovirus viroplasmin RNase_H PF00075.24 EMD59916.1 - 1.5e-30 106.3 0.0 2.7e-30 105.4 0.0 1.4 1 0 0 1 1 1 1 RNase H EcKinase PF02958.20 EMD59918.1 - 6.3e-11 42.1 0.0 3.4e-10 39.7 0.0 2.1 1 1 0 1 1 1 1 Ecdysteroid kinase APH PF01636.23 EMD59918.1 - 3.8e-08 33.5 0.4 3.2e-07 30.5 0.0 2.4 1 1 1 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EMD59918.1 - 0.017 14.7 0.0 0.029 14.0 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase MFS_1 PF07690.16 EMD59919.1 - 4.1e-29 101.6 22.3 4.1e-29 101.6 22.3 1.6 1 1 1 2 2 2 2 Major Facilitator Superfamily Cyclase PF04199.13 EMD59920.1 - 5.7e-13 49.3 0.0 1.7e-12 47.7 0.0 1.7 1 1 0 1 1 1 1 Putative cyclase SesA PF17107.5 EMD59921.1 - 0.0037 17.5 0.2 0.01 16.0 0.2 1.8 1 0 0 1 1 1 1 N-terminal domain on NACHT_NTPase and P-loop NTPases RRP36 PF06102.12 EMD59921.1 - 0.94 9.4 7.0 0.11 12.4 0.6 2.1 1 1 1 2 2 2 0 rRNA biogenesis protein RRP36 AA_permease_2 PF13520.6 EMD59922.1 - 6.1e-54 183.5 49.3 7.7e-54 183.1 49.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EMD59922.1 - 2.5e-25 89.0 42.7 3.3e-25 88.6 42.7 1.0 1 0 0 1 1 1 1 Amino acid permease Acetyltransf_1 PF00583.25 EMD59925.1 - 3.4e-10 40.2 0.0 5.5e-10 39.5 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EMD59925.1 - 4.4e-08 33.1 0.0 7.8e-08 32.3 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EMD59925.1 - 7e-07 29.6 0.0 1.9e-06 28.2 0.0 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EMD59925.1 - 6e-06 26.4 0.0 0.00051 20.1 0.0 2.3 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EMD59925.1 - 0.0015 18.7 0.0 0.0038 17.3 0.0 1.7 2 0 0 2 2 2 1 GCN5-related N-acetyl-transferase FR47 PF08445.10 EMD59925.1 - 0.067 13.2 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 FR47-like protein dCMP_cyt_deam_1 PF00383.23 EMD59926.1 - 7.9e-07 28.9 0.1 1.5e-06 28.0 0.1 1.5 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EMD59926.1 - 0.0018 18.1 0.2 0.0032 17.2 0.2 1.3 1 0 0 1 1 1 1 MafB19-like deaminase MFS_1 PF07690.16 EMD59927.1 - 3.4e-24 85.4 44.9 3.4e-24 85.4 44.9 2.5 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EMD59927.1 - 6.1e-17 61.3 28.0 9.8e-17 60.6 28.0 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EMD59927.1 - 1.7e-06 27.2 8.1 1.7e-06 27.2 8.1 3.0 3 1 1 4 4 4 2 Sugar (and other) transporter 7TM_GPCR_Str PF10326.9 EMD59927.1 - 0.029 13.7 0.0 0.029 13.7 0.0 2.8 4 0 0 4 4 4 0 Serpentine type 7TM GPCR chemoreceptor Str DUF3270 PF11674.8 EMD59927.1 - 0.11 12.6 0.0 0.94 9.7 0.0 2.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3270) NACHT PF05729.12 EMD59928.1 - 5.1e-08 33.0 0.6 5.1e-08 33.0 0.6 1.8 2 0 0 2 2 2 1 NACHT domain Ank_2 PF12796.7 EMD59928.1 - 0.00043 20.8 0.1 0.0013 19.3 0.1 1.9 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) AAA_22 PF13401.6 EMD59928.1 - 0.00044 20.5 0.1 0.0017 18.7 0.1 2.0 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EMD59928.1 - 0.0076 16.6 0.6 0.0076 16.6 0.6 2.1 2 0 0 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 EMD59928.1 - 0.061 13.1 0.0 0.17 11.6 0.0 1.7 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain DUF4391 PF14335.6 EMD59928.1 - 0.21 11.2 1.7 34 4.0 0.1 4.1 3 1 1 4 4 4 0 Domain of unknown function (DUF4391) ORC5_C PF14630.6 EMD59929.1 - 2.3e-77 260.3 0.0 3.2e-77 259.9 0.0 1.2 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 5 C-terminus AAA_16 PF13191.6 EMD59929.1 - 3.8e-13 50.2 0.1 8.2e-13 49.1 0.1 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EMD59929.1 - 0.076 13.3 0.0 0.17 12.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain UPF0061 PF02696.14 EMD59930.1 - 9.7e-131 436.8 0.0 1.3e-130 436.4 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized ACR, YdiU/UPF0061 family WD40 PF00400.32 EMD59931.1 - 0.13 13.1 1.0 0.64 11.0 0.2 2.7 2 1 0 2 2 2 0 WD domain, G-beta repeat ACBP PF00887.19 EMD59932.1 - 1.4e-22 79.7 0.2 3.3e-22 78.5 0.0 1.7 2 0 0 2 2 2 1 Acyl CoA binding protein PepSY_TM PF03929.16 EMD59932.1 - 0.026 14.2 0.3 0.047 13.4 0.2 1.4 1 1 0 1 1 1 0 PepSY-associated TM region GPHH PF16905.5 EMD59934.1 - 0.089 12.6 0.1 0.13 12.1 0.1 1.3 1 0 0 1 1 1 0 Voltage-dependent L-type calcium channel, IQ-associated Sugar_tr PF00083.24 EMD59935.1 - 7.7e-79 265.7 19.1 8.5e-79 265.5 19.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD59935.1 - 5.4e-23 81.5 39.2 7.1e-16 58.1 19.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EMD59935.1 - 0.0024 16.4 2.8 0.0047 15.4 2.8 1.4 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Gly-zipper_Omp PF13488.6 EMD59935.1 - 0.012 15.6 3.5 0.012 15.6 3.5 2.1 2 0 0 2 2 2 0 Glycine zipper Gly-zipper_YMGG PF13441.6 EMD59935.1 - 0.016 15.0 2.9 0.049 13.4 2.9 1.8 1 0 0 1 1 1 0 YMGG-like Gly-zipper zf-RNPHF PF08080.12 EMD59935.1 - 1.7 8.6 4.3 1.1e+02 2.8 0.0 3.4 3 0 0 3 3 3 0 RNPHF zinc finger Rick_17kDa_Anti PF05433.15 EMD59935.1 - 2.4 8.1 11.1 0.37 10.7 6.4 2.1 2 0 0 2 2 2 0 Glycine zipper 2TM domain Polyketide_cyc2 PF10604.9 EMD59936.1 - 0.0016 18.7 0.6 0.0069 16.7 0.1 2.0 2 0 0 2 2 2 1 Polyketide cyclase / dehydrase and lipid transport Pyr_redox_2 PF07992.14 EMD59938.1 - 2.8e-10 39.9 0.0 1e-06 28.2 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EMD59938.1 - 0.013 15.5 0.0 0.63 10.0 0.0 2.5 2 0 0 2 2 2 0 FAD-NAD(P)-binding Lactamase_B PF00753.27 EMD59939.1 - 2.3e-09 37.5 0.1 3.8e-09 36.8 0.1 1.3 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EMD59939.1 - 0.004 16.7 0.2 0.0065 16.0 0.2 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Zn_clus PF00172.18 EMD59940.1 - 6.8e-10 38.9 9.1 6.8e-10 38.9 9.1 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EMD59940.1 - 3.9e-06 26.1 0.0 9.7e-06 24.8 0.0 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain MFS_1 PF07690.16 EMD59942.1 - 4.4e-08 32.5 41.7 8.4e-08 31.5 25.7 2.4 2 1 1 3 3 3 2 Major Facilitator Superfamily Gly-zipper_Omp PF13488.6 EMD59942.1 - 0.019 14.9 2.1 0.08 12.9 2.1 2.1 1 0 0 1 1 1 0 Glycine zipper DUF4922 PF16269.5 EMD59944.1 - 1 9.1 3.6 1.1 9.0 1.7 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4922) Peptidase_M28 PF04389.17 EMD59945.1 - 3.9e-34 118.1 0.0 6.7e-34 117.3 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 EMD59945.1 - 0.00056 19.7 0.0 0.0011 18.7 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 UPF0506 PF11703.8 EMD59947.1 - 0.17 12.3 25.3 0.094 13.1 6.9 2.6 2 1 0 2 2 2 0 UPF0506 Hydrolase_4 PF12146.8 EMD59948.1 - 0.015 14.6 0.0 0.023 14.0 0.0 1.2 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Ndr PF03096.14 EMD59948.1 - 0.016 14.0 0.0 0.024 13.3 0.0 1.2 1 0 0 1 1 1 0 Ndr family AnkUBD PF18418.1 EMD59948.1 - 0.097 12.8 0.0 0.19 11.9 0.0 1.5 1 0 0 1 1 1 0 Ankyrin ubiquitin-binding domain SBP_bac_6 PF13343.6 EMD59949.1 - 6e-11 42.2 1.2 1.1e-10 41.4 1.2 1.4 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_11 PF13531.6 EMD59949.1 - 2.9e-06 27.2 0.3 4.3e-06 26.7 0.2 1.4 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 EMD59949.1 - 0.001 19.1 9.4 0.0033 17.4 9.1 1.9 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein DUF3172 PF11371.8 EMD59952.1 - 0.058 13.1 0.1 0.14 11.8 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3172) APC_u14 PF16635.5 EMD59952.1 - 0.2 12.2 1.4 0.42 11.2 1.4 1.5 1 0 0 1 1 1 0 Unstructured region on APC between SAMP and APC_crr HET PF06985.11 EMD59953.1 - 0.00042 20.7 0.0 0.00062 20.1 0.0 1.3 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) COesterase PF00135.28 EMD59954.1 - 1.5e-82 278.2 0.1 1.1e-70 239.0 0.0 2.1 1 1 1 2 2 2 2 Carboxylesterase family Abhydrolase_3 PF07859.13 EMD59954.1 - 2.6e-11 43.8 0.1 8e-11 42.2 0.1 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EMD59954.1 - 0.027 15.1 0.0 0.046 14.3 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 EMD59954.1 - 0.051 13.1 0.0 0.079 12.4 0.0 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family FAD_binding_4 PF01565.23 EMD59956.1 - 3.6e-17 62.4 0.1 5.7e-17 61.8 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain Molydop_binding PF01568.21 EMD59956.1 - 0.14 12.2 0.0 0.32 11.0 0.0 1.6 1 0 0 1 1 1 0 Molydopterin dinucleotide binding domain Mst1_SARAH PF11629.8 EMD59957.1 - 0.15 12.1 0.4 0.27 11.4 0.4 1.4 1 1 0 1 1 1 0 C terminal SARAH domain of Mst1 HTH_29 PF13551.6 EMD59960.1 - 4.2e-05 23.5 0.0 5.4e-05 23.1 0.0 1.1 1 0 0 1 1 1 1 Winged helix-turn helix HTH_38 PF13936.6 EMD59960.1 - 4.8e-05 23.0 0.1 6.8e-05 22.5 0.1 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_28 PF13518.6 EMD59960.1 - 0.00033 20.7 0.0 0.0004 20.4 0.0 1.1 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_32 PF13565.6 EMD59960.1 - 0.0088 16.6 0.3 0.011 16.3 0.3 1.2 1 0 0 1 1 1 1 Homeodomain-like domain HTH_23 PF13384.6 EMD59960.1 - 0.1 12.5 0.1 0.12 12.2 0.1 1.2 1 0 0 1 1 1 0 Homeodomain-like domain AATase PF07247.12 EMD59962.1 - 2.9e-17 62.4 0.0 2e-16 59.7 0.0 2.1 1 1 0 1 1 1 1 Alcohol acetyltransferase Condensation PF00668.20 EMD59962.1 - 4.8e-05 22.2 0.1 0.00095 17.9 0.2 2.4 3 0 0 3 3 3 1 Condensation domain His_binding PF02098.16 EMD59962.1 - 0.011 15.8 0.0 0.018 15.1 0.0 1.3 1 0 0 1 1 1 0 Tick histamine binding protein WES_acyltransf PF03007.16 EMD59962.1 - 0.069 12.9 0.0 0.11 12.2 0.0 1.2 1 0 0 1 1 1 0 Wax ester synthase-like Acyl-CoA acyltransferase domain AP2 PF00847.20 EMD59963.1 - 0.088 13.1 0.5 0.17 12.2 0.4 1.4 1 1 0 1 1 1 0 AP2 domain RVT_1 PF00078.27 EMD59965.1 - 4.8e-08 32.8 2.4 5.2e-08 32.7 2.4 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Epimerase PF01370.21 EMD59967.1 - 2.8e-16 59.7 0.0 5.1e-16 58.9 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EMD59967.1 - 8.1e-11 41.4 0.0 1.1e-10 41.0 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 EMD59967.1 - 7e-07 28.7 0.1 2.7e-06 26.8 0.1 1.8 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.6 EMD59967.1 - 8.1e-06 25.9 1.4 1.8e-05 24.7 0.1 2.2 2 1 0 2 2 2 1 NAD(P)H-binding Polysacc_synt_2 PF02719.15 EMD59967.1 - 3.9e-05 22.9 0.1 5.8e-05 22.4 0.1 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 EMD59967.1 - 0.00039 19.9 0.1 0.00091 18.7 0.0 1.6 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase KR PF08659.10 EMD59967.1 - 0.0014 18.6 0.0 0.0033 17.3 0.0 1.6 1 0 0 1 1 1 1 KR domain NmrA PF05368.13 EMD59967.1 - 0.002 17.7 0.0 0.0034 17.0 0.0 1.4 1 0 0 1 1 1 1 NmrA-like family PhyH PF05721.13 EMD59968.1 - 5.4e-11 43.2 0.0 8.7e-11 42.5 0.0 1.3 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) 2OG-FeII_Oxy_5 PF13759.6 EMD59968.1 - 0.037 14.4 0.0 0.058 13.8 0.0 1.3 1 0 0 1 1 1 0 Putative 2OG-Fe(II) oxygenase AMP-binding PF00501.28 EMD59969.1 - 2.3e-09 36.3 0.0 3.4e-09 35.8 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EMD59969.1 - 2.1e-08 35.0 0.2 4e-08 34.1 0.0 1.6 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain ABC_tran PF00005.27 EMD59970.1 - 4e-14 53.3 0.0 4.6e-14 53.1 0.0 1.0 1 0 0 1 1 1 1 ABC transporter AAA_29 PF13555.6 EMD59970.1 - 0.17 11.6 0.1 0.34 10.7 0.1 1.5 1 1 0 1 1 1 0 P-loop containing region of AAA domain HemY_N PF07219.13 EMD59971.1 - 0.24 11.6 3.9 0.3 11.3 3.9 1.1 1 0 0 1 1 1 0 HemY protein N-terminus zf-CCHC PF00098.23 EMD59971.1 - 0.26 11.4 3.2 0.43 10.7 3.2 1.3 1 0 0 1 1 1 0 Zinc knuckle ABC_membrane PF00664.23 EMD59972.1 - 7.7e-90 301.3 38.6 5.8e-46 157.3 13.0 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EMD59972.1 - 7.6e-62 207.9 0.0 1.1e-29 103.7 0.0 2.6 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EMD59972.1 - 8.2e-13 48.3 2.6 0.00018 21.0 0.0 4.3 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 EMD59972.1 - 1.1e-08 35.7 3.1 0.0014 19.0 0.0 3.6 2 1 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 EMD59972.1 - 1.9e-07 31.5 0.6 0.041 14.1 0.0 3.8 2 2 0 2 2 2 2 AAA domain AAA_29 PF13555.6 EMD59972.1 - 2.2e-07 30.5 0.4 0.011 15.5 0.1 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain ABC_ATPase PF09818.9 EMD59972.1 - 4.1e-07 29.2 0.2 0.044 12.6 0.0 3.1 3 0 0 3 3 3 2 Predicted ATPase of the ABC class RsgA_GTPase PF03193.16 EMD59972.1 - 3.4e-06 27.1 0.0 0.043 13.7 0.0 2.9 2 0 0 2 2 2 2 RsgA GTPase AAA_25 PF13481.6 EMD59972.1 - 1.5e-05 24.7 0.1 0.17 11.4 0.0 2.9 3 0 0 3 3 3 2 AAA domain AAA_21 PF13304.6 EMD59972.1 - 6.7e-05 22.8 0.1 2 8.2 0.1 4.2 4 0 0 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system SbcCD_C PF13558.6 EMD59972.1 - 0.00013 22.1 2.5 0.22 11.8 0.2 4.0 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_15 PF13175.6 EMD59972.1 - 0.00021 21.1 0.0 0.048 13.4 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain AAA_28 PF13521.6 EMD59972.1 - 0.00022 21.5 0.0 0.1 12.9 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EMD59972.1 - 0.00037 20.3 0.4 1.4 8.6 0.0 3.5 3 1 0 3 3 3 2 AAA domain Zeta_toxin PF06414.12 EMD59972.1 - 0.0011 18.3 0.0 2.3 7.4 0.0 3.0 3 0 0 3 3 3 2 Zeta toxin AAA_5 PF07728.14 EMD59972.1 - 0.0013 18.7 0.1 1.1 9.2 0.0 3.3 3 1 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 EMD59972.1 - 0.0071 16.9 0.0 4.3 7.9 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_23 PF13476.6 EMD59972.1 - 0.0076 16.8 0.1 5.2 7.5 0.0 2.8 2 0 0 2 2 2 1 AAA domain DUF87 PF01935.17 EMD59972.1 - 0.011 15.9 0.7 1.4 9.0 0.1 2.8 3 0 0 3 3 2 0 Helicase HerA, central domain AAA_33 PF13671.6 EMD59972.1 - 0.012 15.7 2.8 3.7 7.7 0.2 3.1 3 0 0 3 3 3 0 AAA domain PRK PF00485.18 EMD59972.1 - 0.018 14.7 0.7 7.3 6.3 0.0 3.4 3 0 0 3 3 3 0 Phosphoribulokinase / Uridine kinase family ResIII PF04851.15 EMD59972.1 - 0.019 15.0 0.6 0.4 10.7 0.1 2.6 3 0 0 3 3 2 0 Type III restriction enzyme, res subunit G-alpha PF00503.20 EMD59972.1 - 0.022 13.9 0.0 4.1 6.5 0.0 2.3 2 0 0 2 2 2 0 G-protein alpha subunit Ploopntkinase3 PF18751.1 EMD59972.1 - 0.042 13.8 0.1 8.8 6.2 0.0 2.5 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 AAA_7 PF12775.7 EMD59972.1 - 0.043 13.3 0.0 3 7.3 0.0 2.6 2 0 0 2 2 2 0 P-loop containing dynein motor region SRP54 PF00448.22 EMD59972.1 - 0.06 13.0 0.1 14 5.3 0.0 2.6 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain RNA_helicase PF00910.22 EMD59972.1 - 0.074 13.4 0.0 6.5 7.2 0.0 2.9 2 0 0 2 2 2 0 RNA helicase MMR_HSR1 PF01926.23 EMD59972.1 - 0.084 13.0 0.1 7.6 6.7 0.0 2.9 2 0 0 2 2 2 0 50S ribosome-binding GTPase DDE_1 PF03184.19 EMD59973.1 - 2.9e-07 30.3 0.0 2.9e-07 30.3 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease zf-CCHC_2 PF13696.6 EMD59974.1 - 0.0048 16.7 1.5 0.0065 16.3 1.5 1.2 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC PF00098.23 EMD59974.1 - 0.0048 16.9 2.1 0.0066 16.5 2.1 1.2 1 0 0 1 1 1 1 Zinc knuckle Rpr2 PF04032.16 EMD59974.1 - 0.071 13.4 3.5 0.078 13.3 3.5 1.0 1 0 0 1 1 1 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain PhyH PF05721.13 EMD59975.1 - 2.2e-31 109.8 0.0 3e-31 109.3 0.0 1.2 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) 2OG-FeII_Oxy_5 PF13759.6 EMD59975.1 - 0.0027 18.1 0.0 0.0044 17.4 0.0 1.4 1 0 0 1 1 1 1 Putative 2OG-Fe(II) oxygenase DUF1479 PF07350.12 EMD59975.1 - 0.12 11.1 0.0 4.1 6.1 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1479) adh_short PF00106.25 EMD59976.1 - 6.6e-24 84.5 4.5 4.7e-18 65.4 3.6 2.1 1 1 1 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EMD59976.1 - 2.9e-14 53.2 4.3 1.8e-11 44.1 3.4 2.1 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.6 EMD59976.1 - 0.0058 16.5 0.1 0.0087 16.0 0.1 1.4 1 0 0 1 1 1 1 NAD(P)H-binding GMC_oxred_N PF00732.19 EMD59977.1 - 1.1e-57 195.7 0.0 1.6e-57 195.1 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EMD59977.1 - 3e-31 108.9 0.1 6e-31 107.9 0.1 1.5 1 0 0 1 1 1 1 GMC oxidoreductase Lycopene_cycl PF05834.12 EMD59977.1 - 4.6e-06 25.9 0.0 8.7e-06 25.0 0.0 1.4 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_2 PF07992.14 EMD59977.1 - 4.6e-05 22.8 0.1 0.00033 20.0 0.1 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EMD59977.1 - 0.00013 22.1 0.0 0.00036 20.7 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EMD59977.1 - 0.00016 21.4 3.6 0.0015 18.1 3.6 2.2 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EMD59977.1 - 0.00079 18.6 0.7 0.0048 16.0 0.6 2.0 2 0 0 2 2 2 1 FAD binding domain HI0933_like PF03486.14 EMD59977.1 - 0.001 17.9 0.1 0.0016 17.2 0.1 1.3 1 0 0 1 1 1 1 HI0933-like protein Thi4 PF01946.17 EMD59977.1 - 0.0023 17.2 0.1 0.0052 16.1 0.1 1.5 1 0 0 1 1 1 1 Thi4 family Pyr_redox_3 PF13738.6 EMD59977.1 - 0.0075 15.5 0.7 0.042 13.1 0.1 2.3 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EMD59977.1 - 0.026 15.1 0.3 0.3 11.7 0.0 2.6 3 0 0 3 3 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EMD59977.1 - 0.055 13.5 0.1 0.14 12.2 0.1 1.7 1 0 0 1 1 1 0 FAD-NAD(P)-binding zf-MYND PF01753.18 EMD59978.1 - 0.038 14.1 1.7 0.061 13.4 1.7 1.3 1 0 0 1 1 1 0 MYND finger DUF1660 PF07874.11 EMD59978.1 - 0.15 12.6 1.1 0.18 12.3 0.8 1.4 1 1 0 1 1 1 0 Prophage protein (DUF1660) zinc_ribbon_12 PF11331.8 EMD59978.1 - 0.52 10.2 4.1 5 7.0 3.0 2.2 1 1 1 2 2 2 0 Probable zinc-ribbon domain p450 PF00067.22 EMD59979.1 - 4.1e-51 174.2 0.0 5.1e-51 173.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF1768 PF08719.11 EMD59980.1 - 2.4e-44 151.4 0.0 2.8e-44 151.2 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1768) Hepsin-SRCR PF09272.10 EMD59980.1 - 0.13 12.8 0.0 0.22 12.1 0.0 1.3 1 0 0 1 1 1 0 Hepsin, SRCR domain adh_short_C2 PF13561.6 EMD59982.1 - 1e-38 133.3 0.0 1.5e-38 132.7 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EMD59982.1 - 5.3e-29 101.1 0.0 8.5e-29 100.4 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase Polysacc_deac_1 PF01522.21 EMD59982.1 - 8.5e-12 45.1 0.0 1.6e-11 44.1 0.0 1.5 1 0 0 1 1 1 1 Polysaccharide deacetylase DUF2334 PF10096.9 EMD59982.1 - 0.00019 21.2 0.0 0.00044 20.0 0.0 1.7 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2334) KR PF08659.10 EMD59982.1 - 0.00054 19.9 0.2 0.0067 16.3 0.2 2.3 1 1 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 EMD59982.1 - 0.0012 18.8 0.0 0.0021 18.0 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EMD59982.1 - 0.0076 15.7 0.0 0.021 14.3 0.0 1.7 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family Glyco_hydro_57 PF03065.15 EMD59982.1 - 0.078 12.2 0.4 0.16 11.2 0.0 1.6 2 0 0 2 2 2 0 Glycosyl hydrolase family 57 DUF3674 PF12426.8 EMD59982.1 - 1.9 8.6 3.5 25 5.0 1.2 2.5 2 0 0 2 2 2 0 RNA dependent RNA polymerase IF-2B PF01008.17 EMD59983.1 - 4.8e-59 199.9 0.4 1.1e-34 119.9 0.0 2.6 2 1 0 2 2 2 2 Initiation factor 2 subunit family Tox-HNH-EHHH PF15657.6 EMD59983.1 - 0.16 12.3 0.4 0.37 11.2 0.4 1.5 1 0 0 1 1 1 0 HNH/Endo VII superfamily nuclease toxins NIF PF03031.18 EMD59984.1 - 4.6e-56 188.9 0.0 6.5e-56 188.4 0.0 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase DUF919 PF06034.11 EMD59984.1 - 0.21 11.4 0.2 0.4 10.5 0.2 1.4 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF919) AAA_22 PF13401.6 EMD59985.1 - 0.0046 17.2 0.3 0.019 15.2 0.0 2.0 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 EMD59985.1 - 0.035 14.0 0.2 0.14 12.1 0.2 2.0 1 1 0 1 1 1 0 NACHT domain Alg14 PF08660.11 EMD59986.1 - 6.7e-33 114.1 0.0 3.3e-15 56.4 0.0 2.2 1 1 1 2 2 2 2 Oligosaccharide biosynthesis protein Alg14 like YjeF_N PF03853.15 EMD59986.1 - 0.064 13.1 0.0 0.095 12.6 0.0 1.2 1 0 0 1 1 1 0 YjeF-related protein N-terminus KOW PF00467.29 EMD59987.1 - 0.001 19.0 3.4 0.0049 16.8 3.3 2.2 2 0 0 2 2 2 1 KOW motif Osteoregulin PF07175.11 EMD59987.1 - 2.1 8.5 8.3 0.42 10.8 0.3 2.8 2 0 0 2 2 2 0 Osteoregulin Ima1_N PF09779.9 EMD59988.1 - 2.1e-34 119.3 3.1 4.2e-34 118.3 3.1 1.6 1 0 0 1 1 1 1 Ima1 N-terminal domain DZR PF12773.7 EMD59988.1 - 0.00032 20.6 4.8 0.19 11.7 0.3 2.4 2 0 0 2 2 2 2 Double zinc ribbon Rubredoxin PF00301.20 EMD59988.1 - 0.06 13.4 0.2 0.2 11.7 0.2 2.0 1 0 0 1 1 1 0 Rubredoxin OrfB_Zn_ribbon PF07282.11 EMD59988.1 - 0.35 10.8 1.5 0.99 9.4 1.5 1.8 1 0 0 1 1 1 0 Putative transposase DNA-binding domain C1_2 PF03107.16 EMD59988.1 - 0.41 11.0 3.6 1.5 9.2 1.1 2.5 2 0 0 2 2 2 0 C1 domain zinc_ribbon_10 PF10058.9 EMD59988.1 - 0.77 9.5 5.9 3.9 7.3 1.4 3.0 3 0 0 3 3 3 0 Predicted integral membrane zinc-ribbon metal-binding protein Ribosom_S12_S23 PF00164.25 EMD59989.1 - 5.1e-51 171.1 0.6 6.3e-51 170.8 0.6 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 DUF5315 PF17242.2 EMD59990.1 - 6.5e-24 83.5 5.4 1.8e-23 82.2 5.4 1.7 1 0 0 1 1 1 1 Disordered region of unknown function (DUF5315) Cluap1 PF10234.9 EMD59990.1 - 0.00032 20.2 1.5 0.00032 20.2 1.5 1.4 2 0 0 2 2 2 1 Clusterin-associated protein-1 Nucleo_P87 PF07267.11 EMD59990.1 - 0.045 12.6 9.3 0.068 12.0 9.3 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 MFS_1 PF07690.16 EMD59991.1 - 6.5e-38 130.6 22.8 6.5e-38 130.6 22.8 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily CoA_binding_3 PF13727.6 EMD59991.1 - 0.32 11.0 4.8 1.3 9.1 0.0 2.8 3 0 0 3 3 3 0 CoA-binding domain PepSY_TM_like_2 PF16357.5 EMD59991.1 - 1.3 8.9 9.4 0.39 10.7 1.2 3.1 3 0 0 3 3 3 0 Putative PepSY_TM-like Peptidase_A8 PF01252.18 EMD59991.1 - 1.6 9.0 7.9 7.7 6.7 0.2 3.2 3 1 0 3 3 3 0 Signal peptidase (SPase) II Acyl_transf_3 PF01757.22 EMD59991.1 - 4.1 6.4 39.2 0.13 11.3 15.6 2.8 2 1 1 3 3 3 0 Acyltransferase family DUF1772 PF08592.11 EMD59991.1 - 6.2 7.1 11.0 14 6.0 0.0 3.9 3 1 0 4 4 4 0 Domain of unknown function (DUF1772) JHY PF15261.6 EMD59992.1 - 0.014 16.1 3.4 0.52 11.0 0.0 2.3 2 0 0 2 2 2 0 Jhy protein PurS PF02700.14 EMD59992.1 - 0.17 12.1 0.0 0.36 11.0 0.0 1.5 1 0 0 1 1 1 0 Phosphoribosylformylglycinamidine (FGAM) synthase ArfGap PF01412.18 EMD59992.1 - 3.3 7.8 5.2 0.71 10.0 0.3 2.2 2 0 0 2 2 2 0 Putative GTPase activating protein for Arf peroxidase PF00141.23 EMD59993.1 - 6.7e-47 160.1 0.0 1e-46 159.5 0.0 1.3 1 0 0 1 1 1 1 Peroxidase fn3_3 PF14686.6 EMD59993.1 - 0.032 14.0 0.1 0.067 13.0 0.1 1.4 1 0 0 1 1 1 0 Polysaccharide lyase family 4, domain II Dicty_REP PF05086.12 EMD59994.1 - 0.049 11.6 2.0 0.061 11.3 2.0 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF3439 PF11921.8 EMD59994.1 - 2.7 8.0 7.1 5.6 7.0 7.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Glutaredoxin PF00462.24 EMD59995.1 - 5.2e-16 58.6 0.0 8.9e-16 57.9 0.0 1.4 1 0 0 1 1 1 1 Glutaredoxin DHquinase_I PF01487.15 EMD59996.1 - 8.4e-48 163.6 0.0 1.2e-47 163.1 0.0 1.2 1 0 0 1 1 1 1 Type I 3-dehydroquinase Fungal_trans PF04082.18 EMD59997.1 - 6.4e-21 74.6 0.0 2e-20 72.9 0.0 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD59997.1 - 2.4e-06 27.6 16.6 4e-06 26.8 16.6 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pyr_redox_2 PF07992.14 EMD59998.1 - 4.8e-62 209.8 1.5 9.7e-62 208.8 1.7 1.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 EMD59998.1 - 1.5e-32 112.2 0.5 3.1e-32 111.1 0.5 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 EMD59998.1 - 1.2e-16 61.0 1.9 2.5e-16 60.0 0.1 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EMD59998.1 - 5.8e-13 48.8 6.7 1.4e-12 47.5 6.7 1.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EMD59998.1 - 2.1e-09 37.0 0.4 0.00033 19.9 0.0 2.2 1 1 1 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) FAD_oxidored PF12831.7 EMD59998.1 - 1.4e-05 24.6 0.6 0.0034 16.8 0.1 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EMD59998.1 - 6.1e-05 22.3 5.6 0.16 11.0 2.3 3.4 3 1 0 3 3 3 3 FAD binding domain DAO PF01266.24 EMD59998.1 - 0.0017 18.0 1.9 0.11 12.1 0.0 2.4 2 0 0 2 2 2 1 FAD dependent oxidoreductase HI0933_like PF03486.14 EMD59998.1 - 0.0028 16.4 1.8 3 6.5 0.0 3.3 3 0 0 3 3 3 2 HI0933-like protein 2-Hacid_dh_C PF02826.19 EMD59998.1 - 0.045 13.1 0.7 7.1 6.0 0.1 3.0 3 0 0 3 3 3 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GIDA PF01134.22 EMD59998.1 - 0.1 11.6 2.1 0.54 9.3 1.4 2.2 2 0 0 2 2 2 0 Glucose inhibited division protein A Arabinose_trans PF04602.12 EMD59999.1 - 0.0045 15.9 0.0 0.0054 15.6 0.0 1.0 1 0 0 1 1 1 1 Mycobacterial cell wall arabinan synthesis protein Mito_carr PF00153.27 EMD60000.1 - 2.4e-43 146.0 5.0 2.2e-15 56.3 0.0 4.2 3 1 0 3 3 3 3 Mitochondrial carrier protein Ribosomal_60s PF00428.19 EMD60001.1 - 8.2e-26 90.4 11.4 1.2e-25 89.8 11.4 1.3 1 0 0 1 1 1 1 60s Acidic ribosomal protein DUF3824 PF12868.7 EMD60001.1 - 7.3 7.3 6.9 10 6.8 6.9 1.2 1 0 0 1 1 1 0 Domain of unknwon function (DUF3824) DUF2408 PF10303.9 EMD60002.1 - 2.7e-46 157.5 13.4 1.3e-27 97.0 2.8 6.0 4 2 1 6 6 6 5 Protein of unknown function (DUF2408) DUF2920 PF11144.8 EMD60002.1 - 0.0022 17.3 0.0 0.045 12.9 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF2920) ApoLp-III PF07464.11 EMD60002.1 - 0.19 11.8 4.1 0.47 10.6 0.5 3.0 3 1 0 3 3 3 0 Apolipophorin-III precursor (apoLp-III) FlaC_arch PF05377.11 EMD60002.1 - 7.3 7.1 6.9 15 6.1 0.8 3.6 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) SET PF00856.28 EMD60003.1 - 7.6e-17 62.2 0.0 2.5e-15 57.3 0.0 2.0 1 1 0 1 1 1 1 SET domain SAF PF08666.12 EMD60003.1 - 0.015 15.9 0.0 1.5 9.5 0.0 2.2 2 0 0 2 2 2 0 SAF domain YHYH PF14240.6 EMD60003.1 - 0.034 14.1 0.1 0.042 13.8 0.1 1.1 1 0 0 1 1 1 0 YHYH protein DUF974 PF06159.13 EMD60004.1 - 3.4e-79 266.1 0.0 4.1e-79 265.9 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF974) HTH_Tnp_Tc5 PF03221.16 EMD60005.1 - 4.1e-09 36.3 0.1 8.1e-09 35.4 0.1 1.5 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EMD60005.1 - 0.0016 18.1 0.1 0.0025 17.5 0.1 1.3 1 0 0 1 1 1 1 helix-turn-helix, Psq domain Drf_GBD PF06371.13 EMD60005.1 - 0.018 14.6 0.0 0.022 14.3 0.0 1.1 1 0 0 1 1 1 0 Diaphanous GTPase-binding Domain Ribosomal_S13_N PF08069.12 EMD60005.1 - 0.03 14.4 0.0 0.057 13.5 0.0 1.4 1 0 0 1 1 1 0 Ribosomal S13/S15 N-terminal domain Cdc6_C PF09079.11 EMD60005.1 - 0.059 13.3 0.2 8.3 6.5 0.0 2.6 3 0 0 3 3 3 0 CDC6, C terminal winged helix domain HTH_24 PF13412.6 EMD60005.1 - 0.093 12.3 0.1 0.7 9.5 0.0 2.2 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding DUF2721 PF11026.8 EMD60005.1 - 0.4 10.6 1.0 0.76 9.7 1.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2721) DENN PF02141.21 EMD60006.1 - 3.8e-57 193.3 0.1 7.8e-57 192.2 0.1 1.6 1 0 0 1 1 1 1 DENN (AEX-3) domain uDENN PF03456.18 EMD60006.1 - 2e-17 63.7 0.0 5.8e-17 62.2 0.0 1.9 1 0 0 1 1 1 1 uDENN domain dDENN PF03455.19 EMD60006.1 - 4.7e-14 52.1 0.5 1.1e-13 50.9 0.5 1.7 1 0 0 1 1 1 1 dDENN domain C1_2 PF03107.16 EMD60006.1 - 4.6e-05 23.6 4.4 9.8e-05 22.6 4.4 1.5 1 0 0 1 1 1 1 C1 domain Zf_RING PF16744.5 EMD60006.1 - 0.1 12.7 4.9 0.21 11.7 4.9 1.4 1 0 0 1 1 1 0 KIAA1045 RING finger C1_1 PF00130.22 EMD60006.1 - 0.51 10.3 8.0 0.89 9.5 8.0 1.3 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) PHD PF00628.29 EMD60006.1 - 1.7 8.6 9.2 3.4 7.6 9.2 1.5 1 0 0 1 1 1 0 PHD-finger PgpA PF04608.13 EMD60009.1 - 0.03 14.3 0.1 0.036 14.1 0.1 1.1 1 0 0 1 1 1 0 Phosphatidylglycerophosphatase A RGS PF00615.19 EMD60010.1 - 1.7e-30 105.7 0.7 4.8e-30 104.3 0.2 2.0 3 0 0 3 3 3 1 Regulator of G protein signaling domain DEP PF00610.21 EMD60010.1 - 2.8e-22 78.6 0.0 2e-15 56.6 0.0 3.5 3 0 0 3 3 3 2 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Replic_Relax PF13814.6 EMD60010.1 - 0.0014 18.7 0.0 0.5 10.4 0.0 2.4 2 0 0 2 2 2 2 Replication-relaxation DUF1304 PF06993.12 EMD60010.1 - 0.095 12.7 0.1 0.21 11.6 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1304) p450 PF00067.22 EMD60011.1 - 3.5e-39 134.8 0.0 1.7e-37 129.3 0.0 2.3 1 1 0 1 1 1 1 Cytochrome P450 Aldo_ket_red PF00248.21 EMD60012.1 - 4.6e-78 262.4 0.0 5.3e-78 262.2 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Flavoprotein PF02441.19 EMD60013.1 - 1.6e-44 151.4 0.0 6.4e-44 149.5 0.0 1.8 1 1 0 1 1 1 1 Flavoprotein Peptidase_S41 PF03572.18 EMD60015.1 - 3.8e-07 29.8 0.0 7.4e-07 28.9 0.0 1.6 1 0 0 1 1 1 1 Peptidase family S41 Pkinase PF00069.25 EMD60016.1 - 2.4e-59 200.9 0.0 3.3e-59 200.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD60016.1 - 6.9e-29 100.9 0.0 9.6e-29 100.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMD60016.1 - 7.7e-10 38.6 0.0 1.1e-09 38.1 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EMD60016.1 - 0.0012 18.3 0.0 0.0021 17.4 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family AIM5 PF17050.5 EMD60017.1 - 9.1e-16 58.4 0.3 1.4e-15 57.8 0.3 1.3 1 0 0 1 1 1 1 Altered inheritance of mitochondria 5 DUF4816 PF16086.5 EMD60017.1 - 0.036 14.0 0.2 0.06 13.3 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4816) CHASE8 PF17152.4 EMD60017.1 - 0.069 13.4 0.0 0.1 12.8 0.0 1.4 1 0 0 1 1 1 0 Periplasmic sensor domain adh_short_C2 PF13561.6 EMD60019.1 - 3.8e-59 200.1 0.1 5e-59 199.7 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EMD60019.1 - 1.6e-49 168.0 0.2 2.1e-49 167.7 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EMD60019.1 - 6.3e-07 29.5 0.2 1.2e-06 28.5 0.2 1.4 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 EMD60019.1 - 0.0089 15.5 0.1 0.056 12.9 0.0 2.1 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family Aldedh PF00171.22 EMD60020.1 - 1.6e-155 518.2 0.1 1.8e-155 518.0 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family NCBP3 PF10309.9 EMD60021.1 - 3.5e-11 42.8 0.0 6.2e-11 42.0 0.0 1.4 1 0 0 1 1 1 1 Nuclear cap-binding protein subunit 3 zf-CCHC_3 PF13917.6 EMD60022.1 - 1.7e-18 66.3 3.0 1.7e-18 66.3 3.0 2.3 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC PF00098.23 EMD60022.1 - 0.073 13.2 1.3 0.12 12.5 1.3 1.4 1 0 0 1 1 1 0 Zinc knuckle SUZ PF12752.7 EMD60023.1 - 9.3e-15 55.1 5.3 9.3e-15 55.1 5.3 3.7 4 1 0 4 4 4 1 SUZ domain R3H PF01424.22 EMD60023.1 - 1.5e-06 28.1 0.0 3.6e-06 26.9 0.0 1.7 1 0 0 1 1 1 1 R3H domain BTB PF00651.31 EMD60024.1 - 0.00011 22.4 0.0 0.00021 21.5 0.0 1.4 2 0 0 2 2 2 1 BTB/POZ domain SKG6 PF08693.10 EMD60026.1 - 2.3e-08 33.3 1.7 5.3e-08 32.1 1.7 1.6 1 0 0 1 1 1 1 Transmembrane alpha-helix domain TMEM154 PF15102.6 EMD60026.1 - 7.3e-05 22.7 0.3 0.00025 21.0 0.0 2.1 2 1 0 2 2 2 1 TMEM154 protein family CD34_antigen PF06365.12 EMD60026.1 - 0.00057 19.5 0.0 0.00089 18.9 0.0 1.3 1 0 0 1 1 1 1 CD34/Podocalyxin family DUF4448 PF14610.6 EMD60026.1 - 0.0062 16.3 0.0 0.0094 15.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) PAP_PilO PF06864.12 EMD60026.1 - 0.01 14.7 0.0 0.01 14.7 0.0 1.9 2 0 0 2 2 2 0 Pilin accessory protein (PilO) EphA2_TM PF14575.6 EMD60026.1 - 0.085 13.7 0.0 0.17 12.8 0.0 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF2207 PF09972.9 EMD60026.1 - 0.19 10.5 0.0 0.24 10.1 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Hamartin PF04388.12 EMD60026.1 - 1.4 7.4 4.3 1.7 7.2 4.3 1.1 1 0 0 1 1 1 0 Hamartin protein Steroid_dh PF02544.16 EMD60027.1 - 3.3e-20 72.6 4.4 5.4e-20 71.9 0.6 2.5 2 1 0 2 2 2 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.12 EMD60027.1 - 0.00059 19.4 1.6 0.0011 18.5 1.3 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF1295) NLPC_P60 PF00877.19 EMD60027.1 - 0.14 12.2 0.0 0.21 11.6 0.0 1.3 1 0 0 1 1 1 0 NlpC/P60 family Sugar_tr PF00083.24 EMD60028.1 - 1.8e-142 475.4 27.7 2.1e-142 475.2 27.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD60028.1 - 7.4e-24 84.3 52.3 3.3e-19 69.0 27.0 2.8 1 1 2 3 3 3 2 Major Facilitator Superfamily Pox_A14 PF05767.12 EMD60028.1 - 0.068 13.3 0.0 0.068 13.3 0.0 2.9 3 0 0 3 3 3 0 Poxvirus virion envelope protein A14 DUF2530 PF10745.9 EMD60028.1 - 0.48 10.7 6.1 0.26 11.5 2.5 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2530) PPR_2 PF13041.6 EMD60030.1 - 1e-31 108.9 1.8 1.3e-14 54.1 0.0 4.2 3 1 1 4 4 4 3 PPR repeat family PPR_3 PF13812.6 EMD60030.1 - 7.3e-19 67.6 0.0 8.3e-08 32.2 0.1 3.1 2 0 0 2 2 2 2 Pentatricopeptide repeat domain PPR PF01535.20 EMD60030.1 - 7.6e-15 54.0 3.5 3.8e-05 23.6 0.0 6.2 6 0 0 6 6 6 4 PPR repeat PPR_1 PF12854.7 EMD60030.1 - 3.1e-13 49.2 0.7 5.2e-05 22.9 0.0 5.0 5 0 0 5 5 5 3 PPR repeat PPR_long PF17177.4 EMD60030.1 - 3.8e-09 36.2 0.2 1.4e-05 24.6 0.1 2.5 2 0 0 2 2 2 2 Pentacotripeptide-repeat region of PRORP cwf18 PF08315.12 EMD60031.1 - 5.2e-41 140.5 12.4 5.2e-41 140.5 12.4 1.9 2 0 0 2 2 2 1 cwf18 pre-mRNA splicing factor DUF1178 PF06676.11 EMD60031.1 - 7.6 6.9 13.6 16 5.8 7.2 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1178) Thiolase_N PF00108.23 EMD60032.1 - 3.3e-14 52.9 0.0 5.1e-13 49.0 0.0 2.4 2 1 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EMD60032.1 - 8.8e-11 41.5 1.3 2.5e-10 40.0 0.2 2.3 2 1 1 3 3 3 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 EMD60032.1 - 3e-05 23.7 0.1 7.1e-05 22.5 0.0 1.7 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.10 EMD60032.1 - 6.2e-05 22.8 0.0 0.0012 18.7 0.0 2.4 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III S4 PF01479.25 EMD60032.1 - 0.004 16.8 0.0 0.0096 15.6 0.0 1.7 1 0 0 1 1 1 1 S4 domain Ketoacyl-synt_C PF02801.22 EMD60032.1 - 0.018 15.1 0.7 1.8 8.6 0.0 3.2 4 0 0 4 4 4 0 Beta-ketoacyl synthase, C-terminal domain ANAPC9 PF12856.7 EMD60033.1 - 0.069 13.3 2.4 0.14 12.4 2.4 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 9 CENP-B_dimeris PF09026.10 EMD60033.1 - 1 9.8 7.1 1.8 9.0 7.1 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Kelch_5 PF13854.6 EMD60034.1 - 1.3e-10 41.0 14.3 6.9e-10 38.7 0.7 5.2 6 0 0 6 6 6 1 Kelch motif Kelch_4 PF13418.6 EMD60034.1 - 2.2e-05 24.4 13.2 0.21 11.6 0.4 5.1 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_3 PF13415.6 EMD60034.1 - 0.00018 21.7 7.8 0.0078 16.5 0.3 4.9 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_1 PF01344.25 EMD60034.1 - 0.0053 16.3 4.3 12 5.6 0.0 4.8 5 0 0 5 5 5 1 Kelch motif Kelch_6 PF13964.6 EMD60034.1 - 0.015 15.5 9.8 3.4 8.1 1.0 4.6 3 1 1 4 4 4 0 Kelch motif EphA2_TM PF14575.6 EMD60034.1 - 0.12 13.2 0.0 0.42 11.5 0.0 1.9 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Syndecan PF01034.20 EMD60034.1 - 0.18 11.7 0.2 0.38 10.7 0.2 1.5 1 0 0 1 1 1 0 Syndecan domain Gly-zipper_Omp PF13488.6 EMD60034.1 - 3.2 7.8 11.7 0.035 14.1 2.6 2.3 2 0 0 2 2 2 0 Glycine zipper DUF1180 PF06679.12 EMD60034.1 - 4.6 7.6 9.1 0.22 11.9 0.5 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF1180) DUF1360 PF07098.11 EMD60035.1 - 0.0082 16.1 0.9 0.082 12.9 0.0 2.6 3 0 0 3 3 3 1 Protein of unknown function (DUF1360) Aminotran_4 PF01063.19 EMD60036.1 - 5.6e-22 78.7 0.0 8.8e-22 78.1 0.0 1.3 1 0 0 1 1 1 1 Amino-transferase class IV CFEM PF05730.11 EMD60037.1 - 2.3e-11 43.6 12.2 4.8e-11 42.6 12.2 1.5 1 0 0 1 1 1 1 CFEM domain DUF1319 PF07028.11 EMD60037.1 - 0.23 11.7 0.1 0.43 10.8 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1319) Virul_fac_BrkB PF03631.15 EMD60037.1 - 1.1 8.8 8.6 0.15 11.6 1.5 2.5 2 1 0 2 2 2 0 Virulence factor BrkB CRM1_C PF08767.11 EMD60038.1 - 8.4e-134 445.8 3.4 8.4e-134 445.8 3.4 3.2 3 1 0 3 3 3 1 CRM1 C terminal Xpo1 PF08389.12 EMD60038.1 - 1.2e-38 132.6 2.5 1.2e-38 132.6 2.5 3.8 3 1 1 4 4 4 1 Exportin 1-like protein CRM1_repeat_2 PF18784.1 EMD60038.1 - 1.1e-33 114.7 2.4 3.4e-33 113.1 2.4 2.0 1 0 0 1 1 1 1 CRM1 / Exportin repeat 2 CRM1_repeat_3 PF18787.1 EMD60038.1 - 1.3e-29 102.0 0.9 1.3e-29 102.0 0.9 3.0 3 0 0 3 3 3 1 CRM1 / Exportin repeat 3 CRM1_repeat PF18777.1 EMD60038.1 - 2.8e-20 71.5 0.9 8.1e-20 70.0 0.9 1.9 1 0 0 1 1 1 1 Chromosome region maintenance or exportin repeat IBN_N PF03810.19 EMD60038.1 - 1.7e-14 53.4 0.1 8.4e-14 51.2 0.1 2.3 1 0 0 1 1 1 1 Importin-beta N-terminal domain NTF2 PF02136.20 EMD60038.1 - 0.048 14.2 0.3 2.2 8.8 0.2 3.0 2 0 0 2 2 2 0 Nuclear transport factor 2 (NTF2) domain DUF3385 PF11865.8 EMD60038.1 - 0.058 13.3 3.8 0.24 11.3 0.0 3.9 5 0 0 5 5 5 0 Domain of unknown function (DUF3385) Pre-PUA PF17832.1 EMD60038.1 - 0.075 13.7 0.0 0.47 11.2 0.0 2.4 1 0 0 1 1 1 0 Pre-PUA-like domain DRE2_N PF16803.5 EMD60038.1 - 0.11 12.7 0.0 0.51 10.6 0.0 2.1 1 0 0 1 1 1 0 Fe-S cluster assembly protein DRE2 N-terminus Vac14_Fab1_bd PF12755.7 EMD60038.1 - 0.18 12.4 0.7 7.6 7.2 0.0 3.7 3 0 0 3 3 3 0 Vacuolar 14 Fab1-binding region MMS19_C PF12460.8 EMD60038.1 - 0.26 10.3 11.1 0.041 13.0 2.4 3.5 3 3 1 4 4 4 0 RNAPII transcription regulator C-terminal GDPD PF03009.17 EMD60039.1 - 8.7e-06 25.6 0.0 1.3e-05 25.1 0.0 1.3 1 1 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family ABC1 PF03109.16 EMD60040.1 - 2e-33 115.1 0.0 3.4e-33 114.3 0.0 1.4 1 0 0 1 1 1 1 ABC1 family RIO1 PF01163.22 EMD60040.1 - 0.015 14.9 0.0 0.033 13.8 0.0 1.5 1 0 0 1 1 1 0 RIO1 family HECT PF00632.25 EMD60041.1 - 2.2e-99 332.8 0.0 3.1e-99 332.3 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.26 EMD60041.1 - 3.6e-33 113.3 21.9 3.8e-12 46.1 3.3 4.0 4 0 0 4 4 4 3 WW domain C2 PF00168.30 EMD60041.1 - 3.3e-20 72.3 0.0 7.7e-20 71.1 0.0 1.6 1 0 0 1 1 1 1 C2 domain DUF1857 PF08982.11 EMD60042.1 - 9.7e-56 187.7 0.0 1.1e-55 187.5 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1857) Serglycin PF04360.12 EMD60043.1 - 0.079 12.9 0.6 0.12 12.3 0.6 1.3 1 0 0 1 1 1 0 Serglycin DUF2252 PF10009.9 EMD60043.1 - 0.081 12.0 0.0 0.16 11.0 0.0 1.3 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2252) GF_recep_IV PF14843.6 EMD60043.1 - 0.16 11.8 6.5 0.28 11.0 6.4 1.5 1 1 0 1 1 1 0 Growth factor receptor domain IV MSP1_C PF07462.11 EMD60043.1 - 2.5 6.7 7.5 3.5 6.2 7.5 1.1 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus Ribosomal_L31e PF01198.19 EMD60044.1 - 1.9e-40 136.9 0.5 2.5e-40 136.6 0.5 1.1 1 0 0 1 1 1 1 Ribosomal protein L31e zinc_ribbon_6 PF14599.6 EMD60045.1 - 6.1e-22 77.4 3.8 6.1e-22 77.4 3.8 4.0 3 2 1 4 4 4 1 Zinc-ribbon zf-CHY PF05495.12 EMD60045.1 - 2.1e-18 66.6 23.4 2.1e-18 66.6 23.4 3.6 2 1 0 3 3 3 1 CHY zinc finger zf-RING_2 PF13639.6 EMD60045.1 - 2e-08 34.5 3.4 2e-08 34.5 3.4 4.9 3 1 3 6 6 6 1 Ring finger domain zf-RING_5 PF14634.6 EMD60045.1 - 4e-06 26.7 5.7 4e-06 26.7 5.7 5.8 2 1 2 4 4 4 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 EMD60045.1 - 2.8e-05 23.8 6.0 2.8e-05 23.8 6.0 4.6 4 3 1 5 5 5 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_1 PF14446.6 EMD60045.1 - 0.0067 16.3 1.1 0.0067 16.3 1.1 6.1 3 3 3 6 6 6 1 Prokaryotic RING finger family 1 zf-P11 PF03854.14 EMD60045.1 - 0.019 14.6 2.0 0.019 14.6 2.0 4.8 3 2 1 4 4 4 0 P-11 zinc finger BORG_CEP PF14957.6 EMD60045.1 - 2.1 9.5 4.8 0.59 11.3 0.1 2.4 2 0 0 2 2 2 0 Cdc42 effector SDA1 PF05285.12 EMD60045.1 - 4.6 6.6 9.9 7 6.0 9.9 1.2 1 0 0 1 1 1 0 SDA1 PrmA PF06325.13 EMD60046.1 - 1.7e-12 47.3 0.0 3e-12 46.5 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.6 EMD60046.1 - 1.1e-11 44.7 0.0 2.4e-11 43.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMD60046.1 - 5e-10 40.0 0.0 1.2e-09 38.7 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMD60046.1 - 1.5e-07 31.9 0.0 5.5e-07 30.2 0.0 1.9 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EMD60046.1 - 2.6e-07 30.6 0.0 7.2e-07 29.2 0.0 1.7 1 1 1 2 2 2 1 Methyltransferase domain MTS PF05175.14 EMD60046.1 - 2.8e-06 27.0 0.1 4.6e-06 26.3 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_18 PF12847.7 EMD60046.1 - 1.8e-05 24.7 0.0 3.1e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EMD60046.1 - 0.00035 20.0 0.0 0.00089 18.7 0.0 1.6 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_24 PF13578.6 EMD60046.1 - 0.00062 20.8 0.0 0.0012 19.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMD60046.1 - 0.00064 20.4 0.1 0.0023 18.6 0.0 2.1 2 0 0 2 2 1 1 Methyltransferase domain FtsJ PF01728.19 EMD60046.1 - 0.0025 18.0 0.0 0.0053 16.9 0.0 1.5 1 0 0 1 1 1 1 FtsJ-like methyltransferase CMAS PF02353.20 EMD60046.1 - 0.0077 15.6 0.0 0.013 14.9 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Cons_hypoth95 PF03602.15 EMD60046.1 - 0.015 15.0 0.1 0.031 13.9 0.1 1.5 1 0 0 1 1 1 0 Conserved hypothetical protein 95 TehB PF03848.14 EMD60046.1 - 0.015 14.7 0.0 0.026 13.9 0.0 1.4 1 0 0 1 1 1 0 Tellurite resistance protein TehB Methyltransf_9 PF08003.11 EMD60046.1 - 0.018 14.0 0.1 0.032 13.1 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1698) Methyltransf_3 PF01596.17 EMD60046.1 - 0.019 14.1 0.0 0.036 13.2 0.0 1.4 1 0 0 1 1 1 0 O-methyltransferase Methyltransf_32 PF13679.6 EMD60046.1 - 0.02 14.9 0.0 0.038 14.0 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Met_10 PF02475.16 EMD60046.1 - 0.037 13.8 0.0 0.059 13.1 0.0 1.2 1 0 0 1 1 1 0 Met-10+ like-protein PRMT5 PF05185.16 EMD60046.1 - 0.041 13.7 0.0 0.063 13.1 0.0 1.4 1 0 0 1 1 1 0 PRMT5 arginine-N-methyltransferase Methyltransf_16 PF10294.9 EMD60046.1 - 0.069 12.9 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase Rav1p_C PF12234.8 EMD60047.1 - 4.8e-269 894.2 0.0 8.3e-269 893.4 0.0 1.4 1 0 0 1 1 1 1 RAVE protein 1 C terminal NmrA PF05368.13 EMD60048.1 - 6.8e-08 32.4 0.0 8.9e-08 32.0 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EMD60048.1 - 7.4e-05 22.7 0.0 0.0001 22.2 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EMD60048.1 - 0.00044 19.8 0.0 0.0024 17.4 0.0 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family adh_short PF00106.25 EMD60048.1 - 0.052 13.0 0.0 0.1 12.1 0.0 1.5 1 0 0 1 1 1 0 short chain dehydrogenase GDP_Man_Dehyd PF16363.5 EMD60048.1 - 0.069 12.5 0.0 0.097 12.1 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase adh_short_C2 PF13561.6 EMD60048.1 - 0.16 11.5 0.1 0.28 10.7 0.1 1.4 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase AlaDh_PNT_C PF01262.21 EMD60048.1 - 0.2 10.9 0.0 0.41 9.9 0.0 1.6 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Methyltransf_2 PF00891.18 EMD60049.1 - 0.0083 15.4 0.0 0.009 15.3 0.0 1.0 1 0 0 1 1 1 1 O-methyltransferase domain DUF3926 PF13080.6 EMD60049.1 - 0.063 13.2 0.2 0.096 12.6 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3926) Methyltransf_2 PF00891.18 EMD60050.1 - 6.3e-20 71.4 0.1 1.6e-19 70.1 0.1 1.7 1 1 0 1 1 1 1 O-methyltransferase domain TrmB PF01978.19 EMD60050.1 - 4.3e-05 23.3 0.0 8.4e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB Dimerisation2 PF16864.5 EMD60050.1 - 0.0009 19.2 0.0 0.0018 18.2 0.0 1.4 1 0 0 1 1 1 1 Dimerisation domain HTH_IclR PF09339.10 EMD60050.1 - 0.001 18.8 0.0 0.0022 17.8 0.0 1.6 1 0 0 1 1 1 1 IclR helix-turn-helix domain HTH_24 PF13412.6 EMD60050.1 - 0.0018 17.8 0.0 0.0047 16.5 0.0 1.7 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding MarR_2 PF12802.7 EMD60050.1 - 0.0041 17.0 0.0 0.0091 15.9 0.0 1.5 1 0 0 1 1 1 1 MarR family HTH_11 PF08279.12 EMD60050.1 - 0.0042 17.0 0.0 0.0096 15.8 0.0 1.5 1 0 0 1 1 1 1 HTH domain HTH_Crp_2 PF13545.6 EMD60050.1 - 0.0071 16.3 0.0 0.015 15.2 0.0 1.5 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain Rrf2 PF02082.20 EMD60050.1 - 0.011 16.1 0.0 0.021 15.2 0.0 1.5 1 0 0 1 1 1 0 Transcriptional regulator Fe_dep_repress PF01325.19 EMD60050.1 - 0.032 14.4 0.0 0.079 13.2 0.0 1.6 1 0 0 1 1 1 0 Iron dependent repressor, N-terminal DNA binding domain FeoC PF09012.10 EMD60050.1 - 0.07 13.2 0.0 0.17 12.0 0.0 1.6 1 0 0 1 1 1 0 FeoC like transcriptional regulator CENP-B_N PF04218.13 EMD60050.1 - 0.13 11.9 0.0 0.3 10.8 0.0 1.5 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain MarR PF01047.22 EMD60050.1 - 0.14 12.1 0.0 0.33 10.9 0.0 1.6 1 0 0 1 1 1 0 MarR family HTH_23 PF13384.6 EMD60050.1 - 0.14 12.0 0.0 0.29 11.0 0.0 1.5 1 0 0 1 1 1 0 Homeodomain-like domain Gin PF10764.9 EMD60052.1 - 0.048 13.6 0.2 0.069 13.1 0.2 1.2 1 0 0 1 1 1 0 Inhibitor of sigma-G Gin p450 PF00067.22 EMD60053.1 - 8.2e-19 67.7 0.0 8.9e-19 67.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Polysacc_deac_1 PF01522.21 EMD60054.1 - 5.8e-29 100.5 0.0 8.8e-29 99.9 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase Acyl_transf_3 PF01757.22 EMD60055.1 - 1.2e-25 90.3 25.1 3.4e-25 88.8 25.1 1.7 1 1 0 1 1 1 1 Acyltransferase family LIFR_N PF18207.1 EMD60055.1 - 0.11 12.9 0.0 0.2 12.1 0.0 1.4 1 0 0 1 1 1 0 Leukemia inhibitory factor receptor N-terminal domain Chitin_synth_2 PF03142.15 EMD60056.1 - 7.2e-13 48.0 8.4 8.3e-09 34.6 0.0 2.4 2 1 0 2 2 2 2 Chitin synthase Glyco_tranf_2_3 PF13641.6 EMD60056.1 - 1.6e-12 47.8 0.0 8.4e-11 42.2 0.0 2.1 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 EMD60056.1 - 2.8e-09 37.2 1.8 8.2e-09 35.7 1.7 1.8 2 0 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_transf_21 PF13506.6 EMD60056.1 - 1.5e-08 34.3 0.0 3.3e-08 33.2 0.0 1.5 1 1 0 1 1 1 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.26 EMD60056.1 - 0.0085 15.9 0.0 0.014 15.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 XPG_I PF00867.18 EMD60056.1 - 0.074 13.4 0.0 0.14 12.6 0.0 1.5 1 0 0 1 1 1 0 XPG I-region HeH PF12949.7 EMD60056.1 - 0.2 11.4 0.5 0.41 10.4 0.0 1.7 2 0 0 2 2 2 0 HeH/LEM domain Acyl_transf_3 PF01757.22 EMD60057.1 - 5.7e-07 28.9 0.2 5.7e-07 28.9 0.2 1.0 1 0 0 1 1 1 1 Acyltransferase family Glyco_transf_54 PF04666.13 EMD60058.1 - 2.4e-07 29.9 0.1 0.016 14.1 0.1 2.2 2 0 0 2 2 2 2 N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region Glyco_transf_25 PF01755.17 EMD60058.1 - 0.0069 16.3 0.0 0.013 15.4 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 25 (LPS biosynthesis protein) Sec23_trunk PF04811.15 EMD60060.1 - 3.5e-76 256.0 0.0 5.6e-76 255.3 0.0 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 EMD60060.1 - 4.3e-31 107.5 0.0 9.2e-31 106.5 0.0 1.6 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Sec23_helical PF04815.15 EMD60060.1 - 4.9e-26 90.5 0.3 4.1e-25 87.6 0.1 2.5 2 0 0 2 2 2 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.15 EMD60060.1 - 2.2e-15 56.4 6.4 4.2e-15 55.5 6.4 1.5 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 EMD60060.1 - 7.9e-14 51.3 0.0 4.7e-13 48.8 0.0 2.2 2 0 0 2 2 2 1 Gelsolin repeat Vps36-NZF-N PF16988.5 EMD60060.1 - 0.056 12.9 0.4 0.15 11.5 0.1 1.8 2 0 0 2 2 2 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain Cupin_2 PF07883.11 EMD60061.1 - 2.8e-06 26.9 0.1 5.8e-06 25.9 0.1 1.5 1 0 0 1 1 1 1 Cupin domain Cupin_6 PF12852.7 EMD60061.1 - 0.017 14.8 0.1 0.027 14.2 0.1 1.3 1 0 0 1 1 1 0 Cupin RRM_1 PF00076.22 EMD60062.1 - 3.3e-15 55.7 0.1 8.5e-15 54.3 0.1 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RL PF17797.1 EMD60062.1 - 0.011 15.7 1.2 0.025 14.5 0.0 2.1 2 0 0 2 2 2 0 RL domain RRM_5 PF13893.6 EMD60062.1 - 0.076 12.6 0.0 0.16 11.6 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SMN PF06003.12 EMD60063.1 - 4.5e-05 22.8 7.9 0.00016 21.1 0.9 2.2 1 1 1 2 2 2 2 Survival motor neuron protein (SMN) Cu_bind_like PF02298.17 EMD60065.1 - 0.0073 16.3 0.2 0.014 15.4 0.2 1.5 1 1 0 1 1 1 1 Plastocyanin-like domain CAP_N PF01213.19 EMD60065.1 - 3.1 7.2 4.4 4.9 6.5 4.4 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal 4F5 PF04419.14 EMD60066.1 - 8.7e-13 48.9 9.6 8.7e-13 48.9 9.6 2.1 2 0 0 2 2 2 1 4F5 protein family Glyco_hydro_61 PF03443.14 EMD60067.1 - 1.4e-45 155.8 0.0 2.1e-45 155.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 zf-C2H2 PF00096.26 EMD60069.1 - 2.2e-09 37.2 14.9 0.0068 16.8 0.2 4.7 5 0 0 5 5 5 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMD60069.1 - 5.2e-07 30.0 11.3 0.071 14.0 0.2 4.5 4 0 0 4 4 4 3 C2H2-type zinc finger FOXP-CC PF16159.5 EMD60069.1 - 0.039 14.6 1.2 0.9 10.2 0.1 3.3 2 1 1 3 3 3 0 FOXP coiled-coil domain zf-C2H2_6 PF13912.6 EMD60069.1 - 0.067 13.2 7.1 4 7.6 2.7 4.1 4 0 0 4 4 4 0 C2H2-type zinc finger zf-BED PF02892.15 EMD60069.1 - 0.11 12.5 0.6 0.37 10.9 0.6 1.9 1 0 0 1 1 1 0 BED zinc finger zf-H2C2_2 PF13465.6 EMD60069.1 - 2.1 8.9 8.0 14 6.3 0.1 4.2 4 0 0 4 4 4 0 Zinc-finger double domain zf-Di19 PF05605.12 EMD60069.1 - 2.1 8.7 10.3 0.27 11.5 0.9 3.0 3 0 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding EMP24_GP25L PF01105.24 EMD60070.1 - 1.6e-49 168.3 0.0 1.8e-49 168.2 0.0 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD TRAF_BIRC3_bd PF16673.5 EMD60070.1 - 0.024 14.4 0.1 0.045 13.5 0.1 1.3 1 0 0 1 1 1 0 TNF receptor-associated factor BIRC3 binding domain adh_short PF00106.25 EMD60071.1 - 3.3e-31 108.3 0.0 4.6e-31 107.8 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD60071.1 - 2.2e-23 83.1 0.0 2.8e-23 82.7 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD60071.1 - 7.2e-07 29.3 1.2 0.0016 18.4 0.4 2.7 2 1 0 2 2 2 2 KR domain Eno-Rase_NADH_b PF12242.8 EMD60071.1 - 0.0027 17.4 0.1 0.0051 16.6 0.1 1.4 1 0 0 1 1 1 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Epimerase PF01370.21 EMD60071.1 - 0.012 15.0 0.0 0.026 14.0 0.0 1.5 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family SANT_DAMP1_like PF16282.5 EMD60072.1 - 1.7e-29 101.9 2.0 3.4e-29 100.9 2.0 1.5 1 0 0 1 1 1 1 SANT/Myb-like domain of DAMP1 BUD22 PF09073.10 EMD60072.1 - 0.0051 16.2 15.7 0.0051 16.2 15.7 1.9 2 0 0 2 2 2 1 BUD22 DMAP1 PF05499.12 EMD60072.1 - 0.028 14.3 5.8 0.39 10.6 5.3 2.4 1 1 1 2 2 2 0 DNA methyltransferase 1-associated protein 1 (DMAP1) Pkinase PF00069.25 EMD60073.1 - 1.4e-27 96.7 0.0 2.1e-27 96.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD60073.1 - 1.2e-14 54.3 0.0 1.6e-14 53.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EMD60073.1 - 1e-06 27.8 0.0 1e-06 27.8 0.0 1.7 2 0 0 2 2 2 1 Fungal protein kinase Nucleoporin_C PF03177.14 EMD60075.1 - 5.6e-154 514.1 8.6 6.9e-154 513.8 8.6 1.1 1 0 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal Nucleoporin_N PF08801.11 EMD60075.1 - 1.4e-42 146.0 0.0 1.9e-42 145.5 0.0 1.2 1 0 0 1 1 1 1 Nup133 N terminal like FliD_C PF07195.12 EMD60075.1 - 0.049 13.0 0.3 4.5 6.6 0.0 2.4 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 C-terminus HABP4_PAI-RBP1 PF04774.15 EMD60076.1 - 0.012 16.5 5.8 0.022 15.6 5.5 1.7 1 1 0 1 1 1 0 Hyaluronan / mRNA binding family CIAPIN1 PF05093.13 EMD60077.1 - 4.3e-43 145.9 3.3 8e-43 145.0 3.3 1.4 1 0 0 1 1 1 1 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis DRE2_N PF16803.5 EMD60077.1 - 3.2e-37 127.7 0.0 4.3e-37 127.3 0.0 1.2 1 0 0 1 1 1 1 Fe-S cluster assembly protein DRE2 N-terminus Helicase_C PF00271.31 EMD60079.1 - 1e-17 64.4 0.0 2.5e-13 50.3 0.0 3.0 3 0 0 3 3 3 2 Helicase conserved C-terminal domain DEAD PF00270.29 EMD60079.1 - 3.3e-16 59.5 0.0 5.7e-16 58.8 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase RecQ_Zn_bind PF16124.5 EMD60079.1 - 6.7e-13 49.2 1.4 1.3e-12 48.2 1.4 1.5 1 0 0 1 1 1 1 RecQ zinc-binding UBX PF00789.20 EMD60080.1 - 4.3e-07 30.0 0.1 2e-06 27.9 0.0 2.2 2 0 0 2 2 2 1 UBX domain UBA PF00627.31 EMD60080.1 - 2.2e-06 27.4 0.0 6.1e-06 26.0 0.0 1.7 1 0 0 1 1 1 1 UBA/TS-N domain zf-C2H2_2 PF12756.7 EMD60080.1 - 0.11 12.8 0.5 0.11 12.8 0.5 1.9 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) CDC45 PF02724.14 EMD60080.1 - 0.23 9.7 15.0 0.26 9.5 15.0 1.2 1 0 0 1 1 1 0 CDC45-like protein Mitofilin PF09731.9 EMD60080.1 - 0.54 9.0 32.0 0.66 8.7 32.0 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Ribosomal_L11_N PF03946.14 EMD60080.1 - 0.72 9.7 0.0 0.72 9.7 0.0 2.4 2 1 0 2 2 2 0 Ribosomal protein L11, N-terminal domain Exonuc_VII_L PF02601.15 EMD60080.1 - 1.5 8.3 12.4 2.2 7.7 12.4 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit SOBP PF15279.6 EMD60080.1 - 6.4 7.3 11.6 8.8 6.8 11.6 1.3 1 0 0 1 1 1 0 Sine oculis-binding protein HOIP-UBA PF16678.5 EMD60080.1 - 7.7 6.5 20.6 18 5.3 16.1 2.9 2 1 1 3 3 3 0 HOIP UBA domain pair Motile_Sperm PF00635.26 EMD60081.1 - 2.2e-26 91.8 0.0 3.6e-26 91.1 0.0 1.4 1 0 0 1 1 1 1 MSP (Major sperm protein) domain ASH PF15780.5 EMD60081.1 - 0.0087 16.2 0.0 0.021 15.0 0.0 1.6 1 0 0 1 1 1 1 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin Asn_synthase PF00733.21 EMD60082.1 - 2.6e-92 310.3 0.0 3.2e-54 184.9 0.0 2.1 1 1 1 2 2 2 2 Asparagine synthase GATase_7 PF13537.6 EMD60082.1 - 9.9e-36 122.4 0.0 1.7e-35 121.6 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 EMD60082.1 - 1.7e-27 96.3 0.0 2.8e-27 95.5 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain DUF3700 PF12481.8 EMD60082.1 - 1.4e-06 28.0 0.0 2.6e-06 27.1 0.0 1.3 1 0 0 1 1 1 1 Aluminium induced protein NAD_synthase PF02540.17 EMD60082.1 - 0.0072 15.5 0.0 0.015 14.4 0.0 1.6 1 1 0 1 1 1 1 NAD synthase QueC PF06508.13 EMD60082.1 - 0.2 11.1 0.0 0.36 10.3 0.0 1.3 1 0 0 1 1 1 0 Queuosine biosynthesis protein QueC PQ-loop PF04193.14 EMD60083.1 - 3.7e-39 132.3 6.9 1.3e-20 72.9 0.1 3.0 2 1 0 2 2 2 2 PQ loop repeat MtN3_slv PF03083.16 EMD60083.1 - 0.058 13.4 0.4 2.1 8.5 0.0 2.8 3 0 0 3 3 3 0 Sugar efflux transporter for intercellular exchange TMEM132D_C PF15706.5 EMD60083.1 - 0.079 12.7 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term ER_lumen_recept PF00810.18 EMD60083.1 - 0.081 13.7 1.0 7.4 7.4 0.1 2.8 2 1 1 3 3 3 0 ER lumen protein retaining receptor Mid2 PF04478.12 EMD60084.1 - 0.00013 21.8 0.1 0.00013 21.8 0.1 2.0 3 0 0 3 3 3 1 Mid2 like cell wall stress sensor Peroxin-3 PF04882.12 EMD60084.1 - 8.5 5.2 7.6 13 4.6 7.6 1.5 1 1 0 1 1 1 0 Peroxin-3 Ydc2-catalyt PF09159.10 EMD60086.1 - 1e-73 248.5 1.1 1.2e-73 248.3 1.1 1.1 1 0 0 1 1 1 1 Mitochondrial resolvase Ydc2 / RNA splicing MRS1 Pox_A22 PF04848.13 EMD60086.1 - 0.00011 22.4 0.0 2.6 8.1 0.0 3.4 3 0 0 3 3 3 2 Poxvirus A22 protein SAP PF02037.27 EMD60086.1 - 0.047 13.5 0.0 0.086 12.6 0.0 1.4 1 0 0 1 1 1 0 SAP domain Aconitase PF00330.20 EMD60087.1 - 1.3e-143 479.4 0.0 1.9e-143 478.8 0.0 1.3 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 EMD60087.1 - 6.2e-40 136.5 0.0 1.2e-39 135.7 0.0 1.5 1 0 0 1 1 1 1 Aconitase C-terminal domain KH_1 PF00013.29 EMD60087.1 - 5.9e-12 45.2 0.2 8.7e-08 31.9 0.1 2.8 2 0 0 2 2 2 2 KH domain ALS_ss_C PF10369.9 EMD60088.1 - 1.9e-13 50.4 0.0 2.8e-12 46.7 0.0 2.3 2 0 0 2 2 2 1 Small subunit of acetolactate synthase ACT PF01842.25 EMD60088.1 - 3.7e-13 49.0 0.1 6.7e-13 48.2 0.1 1.5 1 0 0 1 1 1 1 ACT domain ACT_5 PF13710.6 EMD60088.1 - 3.3e-08 33.2 0.0 6.4e-08 32.3 0.0 1.5 1 0 0 1 1 1 1 ACT domain DUF2156 PF09924.9 EMD60089.1 - 0.094 11.7 0.0 0.12 11.4 0.0 1.1 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2156) SPX PF03105.19 EMD60091.1 - 2.5e-11 44.1 15.6 0.00021 21.3 0.0 4.3 2 1 2 4 4 4 3 SPX domain VTC PF09359.10 EMD60091.1 - 1.2e-10 41.2 0.0 2.6e-09 36.9 0.0 2.4 1 1 0 1 1 1 1 VTC domain DHHW PF14286.6 EMD60091.1 - 0.059 12.7 0.1 0.12 11.6 0.1 1.4 1 0 0 1 1 1 0 DHHW protein Osmo_CC PF08946.10 EMD60091.1 - 0.067 13.5 1.0 8.6 6.7 0.6 3.5 2 1 0 2 2 2 0 Osmosensory transporter coiled coil STE2 PF02116.15 EMD60091.1 - 1.1 8.4 4.1 3.2 7.0 3.6 1.8 1 1 1 2 2 2 0 Fungal pheromone mating factor STE2 GPCR DAO PF01266.24 EMD60092.1 - 5.1e-51 174.3 0.0 1.4e-50 172.9 0.0 1.7 2 0 0 2 2 2 1 FAD dependent oxidoreductase DAO_C PF16901.5 EMD60092.1 - 2.1e-43 147.2 0.1 4e-43 146.3 0.1 1.5 1 0 0 1 1 1 1 C-terminal domain of alpha-glycerophosphate oxidase FAD_binding_2 PF00890.24 EMD60092.1 - 1.1e-07 31.3 0.1 2.9e-07 29.9 0.1 1.6 1 1 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 EMD60092.1 - 0.00036 20.0 0.1 0.0014 18.1 0.2 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EMD60092.1 - 0.0012 18.1 0.1 0.0041 16.4 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EMD60092.1 - 0.0028 17.9 0.3 0.041 14.1 0.3 2.7 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain 3HCDH_N PF02737.18 EMD60092.1 - 0.058 13.3 0.1 0.13 12.2 0.1 1.6 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain HI0933_like PF03486.14 EMD60092.1 - 0.091 11.4 0.1 0.15 10.8 0.1 1.3 1 0 0 1 1 1 0 HI0933-like protein Pyr_redox_3 PF13738.6 EMD60092.1 - 0.092 12.0 0.0 0.26 10.5 0.0 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase HHH_4 PF14490.6 EMD60092.1 - 0.095 12.7 0.0 20 5.3 0.0 2.6 2 0 0 2 2 2 0 Helix-hairpin-helix containing domain GIDA PF01134.22 EMD60092.1 - 0.11 11.5 0.1 1.1 8.3 0.1 2.1 2 0 0 2 2 2 0 Glucose inhibited division protein A Peroxidase_2 PF01328.17 EMD60093.1 - 6.2e-51 173.6 0.0 8.4e-51 173.2 0.0 1.2 1 0 0 1 1 1 1 Peroxidase, family 2 NifU PF01106.17 EMD60096.1 - 0.77 10.0 2.3 5.9 7.1 0.4 2.3 2 0 0 2 2 2 0 NifU-like domain PNK3P PF08645.11 EMD60097.1 - 1.3e-54 184.3 0.0 2.6e-54 183.3 0.0 1.5 1 0 0 1 1 1 1 Polynucleotide kinase 3 phosphatase AAA_33 PF13671.6 EMD60097.1 - 1.3e-23 83.8 0.0 6.1e-21 75.1 0.0 2.7 1 1 0 1 1 1 1 AAA domain p450 PF00067.22 EMD60098.1 - 3.8e-46 157.8 0.0 4.7e-32 111.4 0.0 2.2 2 0 0 2 2 2 2 Cytochrome P450 Terpene_synth_C PF03936.16 EMD60099.1 - 0.013 14.9 0.0 0.018 14.4 0.0 1.2 1 0 0 1 1 1 0 Terpene synthase family, metal binding domain NB-ARC PF00931.22 EMD60100.1 - 1.2e-05 24.6 0.0 4.1e-05 22.9 0.0 1.9 1 0 0 1 1 1 1 NB-ARC domain Helo_like_N PF17111.5 EMD60100.1 - 0.00011 21.6 0.1 0.00027 20.4 0.1 1.7 1 1 0 1 1 1 1 Fungal N-terminal domain of STAND proteins COG5 PF10392.9 EMD60100.1 - 0.0015 18.7 2.7 0.0026 17.9 0.5 2.5 2 1 0 2 2 2 1 Golgi transport complex subunit 5 DivIC PF04977.15 EMD60100.1 - 0.069 12.9 1.2 1.1 9.1 0.5 2.7 2 0 0 2 2 2 0 Septum formation initiator AAA_18 PF13238.6 EMD60100.1 - 0.077 13.5 0.2 14 6.3 0.0 3.2 3 1 0 3 3 3 0 AAA domain ApoLp-III PF07464.11 EMD60100.1 - 0.78 9.8 4.5 0.6 10.2 0.5 2.5 2 1 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) PhaP_Bmeg PF09602.10 EMD60100.1 - 5.3 6.9 10.3 0.53 10.2 0.3 2.7 2 1 1 3 3 3 0 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) DUF4017 PF13209.6 EMD60101.1 - 0.016 15.2 1.4 0.022 14.7 1.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4017) p450 PF00067.22 EMD60102.1 - 1.7e-71 241.4 0.0 2.2e-71 241.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Med18 PF09637.10 EMD60103.1 - 1.5e-48 165.9 0.0 1.7e-48 165.7 0.0 1.0 1 0 0 1 1 1 1 Med18 protein S36_mt PF10937.8 EMD60104.1 - 5.6e-38 131.1 0.1 6.4e-38 130.9 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S36, mitochondrial Phage_GPA PF05840.13 EMD60104.1 - 0.15 11.1 0.1 0.17 11.0 0.1 1.1 1 0 0 1 1 1 0 Bacteriophage replication gene A protein (GPA) DPBB_1 PF03330.18 EMD60105.1 - 1.3e-05 25.4 0.0 4.1e-05 23.8 0.0 1.8 1 1 0 1 1 1 1 Lytic transglycolase Ank_2 PF12796.7 EMD60106.1 - 1.1e-10 42.0 0.0 2.5e-09 37.6 0.0 2.4 1 1 1 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMD60106.1 - 5.1e-07 30.1 0.7 0.098 13.3 0.0 3.4 2 2 0 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMD60106.1 - 5.3e-05 23.3 0.0 0.044 14.3 0.0 4.1 4 0 0 4 4 4 1 Ankyrin repeat Ank PF00023.30 EMD60106.1 - 0.00089 19.6 0.1 0.19 12.2 0.0 3.8 4 0 0 4 4 4 1 Ankyrin repeat Ank_5 PF13857.6 EMD60106.1 - 0.012 15.9 0.1 0.08 13.3 0.0 2.5 2 1 1 3 3 3 0 Ankyrin repeats (many copies) Tcp11 PF05794.13 EMD60108.1 - 3e-110 369.4 0.1 3e-110 369.4 0.1 2.2 2 0 0 2 2 2 1 T-complex protein 11 UPF0242 PF06785.11 EMD60108.1 - 1.3 9.0 5.6 3.3 7.8 5.6 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DSPc PF00782.20 EMD60109.1 - 2.3e-28 98.6 0.0 3.2e-28 98.2 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Init_tRNA_PT PF04179.12 EMD60109.1 - 0.021 15.1 0.0 0.037 14.3 0.0 1.3 1 0 0 1 1 1 0 Rit1 DUSP-like domain Y_phosphatase PF00102.27 EMD60109.1 - 0.022 14.3 0.0 0.033 13.8 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Yippee-Mis18 PF03226.14 EMD60109.1 - 0.1 12.8 1.2 0.28 11.4 0.7 1.9 1 1 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly zinc_ribbon_4 PF13717.6 EMD60109.1 - 0.13 12.2 3.1 8 6.5 0.1 2.9 2 0 0 2 2 2 0 zinc-ribbon domain Y_phosphatase3 PF13350.6 EMD60109.1 - 0.17 11.8 0.0 0.25 11.3 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family zf-C2H2 PF00096.26 EMD60110.1 - 0.00013 22.2 16.4 0.035 14.6 0.8 4.7 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMD60110.1 - 0.2 12.6 20.8 0.4 11.6 1.2 4.9 4 0 0 4 4 4 0 C2H2-type zinc finger Zn_ribbon_SprT PF17283.2 EMD60110.1 - 0.87 9.5 4.9 15 5.6 3.5 3.1 2 1 1 3 3 3 0 SprT-like zinc ribbon domain zf-MYST PF17772.1 EMD60110.1 - 4.3 7.0 7.3 0.38 10.4 0.6 2.3 1 1 1 2 2 2 0 MYST family zinc finger domain Vfa1 PF08432.10 EMD60111.1 - 1.1e-58 198.6 20.8 1.2e-58 198.4 20.8 1.0 1 0 0 1 1 1 1 AAA-ATPase Vps4-associated protein 1 CDC45 PF02724.14 EMD60111.1 - 0.016 13.5 15.0 0.016 13.5 15.0 1.0 1 0 0 1 1 1 0 CDC45-like protein RR_TM4-6 PF06459.12 EMD60111.1 - 0.019 14.8 16.0 0.024 14.5 16.0 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF2347 PF09804.9 EMD60111.1 - 0.058 13.0 2.0 0.072 12.7 2.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) GNAT_acetyltr_2 PF13718.6 EMD60111.1 - 0.12 11.7 5.6 0.16 11.4 5.6 1.3 1 0 0 1 1 1 0 GNAT acetyltransferase 2 TP53IP5 PF15331.6 EMD60111.1 - 0.18 12.0 11.2 0.24 11.5 11.2 1.2 1 0 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 DUF913 PF06025.12 EMD60111.1 - 0.21 10.5 4.3 0.23 10.4 4.3 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) NPAT_C PF15712.5 EMD60111.1 - 0.26 9.9 10.7 0.28 9.8 10.7 1.0 1 0 0 1 1 1 0 NPAT C terminus DDHD PF02862.17 EMD60111.1 - 0.28 11.3 6.1 0.33 11.1 6.1 1.1 1 0 0 1 1 1 0 DDHD domain SLC12 PF03522.15 EMD60111.1 - 0.51 9.3 12.3 0.57 9.1 12.3 1.1 1 0 0 1 1 1 0 Solute carrier family 12 AAA_11 PF13086.6 EMD60111.1 - 0.75 9.5 12.9 0.89 9.3 12.9 1.2 1 0 0 1 1 1 0 AAA domain DUF262 PF03235.14 EMD60111.1 - 0.83 9.8 10.7 0.99 9.5 10.7 1.1 1 0 0 1 1 1 0 Protein of unknown function DUF262 PPL5 PF18168.1 EMD60111.1 - 1.3 8.3 12.8 1.5 8.0 12.8 1.1 1 0 0 1 1 1 0 Prim-pol family 5 SID-1_RNA_chan PF13965.6 EMD60111.1 - 2.2 6.6 3.1 2.3 6.5 3.1 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 SprA-related PF12118.8 EMD60111.1 - 2.7 7.1 20.2 3.4 6.7 20.2 1.1 1 0 0 1 1 1 0 SprA-related family CENP-Q PF13094.6 EMD60111.1 - 3.1 8.0 22.6 2.3 8.4 21.6 1.3 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit Presenilin PF01080.17 EMD60111.1 - 4.2 6.0 14.4 5.2 5.7 14.4 1.1 1 0 0 1 1 1 0 Presenilin Serinc PF03348.15 EMD60111.1 - 4.3 6.2 4.4 5.1 5.9 4.4 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) Zip PF02535.22 EMD60111.1 - 4.5 6.4 7.5 5.3 6.2 7.5 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter CLN3 PF02487.17 EMD60111.1 - 6.7 5.7 5.7 7.6 5.5 5.7 1.2 1 0 0 1 1 1 0 CLN3 protein DUF4407 PF14362.6 EMD60111.1 - 7.1 5.9 16.3 9.3 5.5 16.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) NPR3 PF03666.13 EMD60111.1 - 8.1 5.1 16.5 9.3 4.9 16.5 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Neur_chan_memb PF02932.16 EMD60111.1 - 8.9 6.3 7.0 10 6.1 7.0 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region VIR_N PF15912.5 EMD60111.1 - 9.3 5.8 12.9 12 5.4 12.9 1.2 1 0 0 1 1 1 0 Virilizer, N-terminal TatD_DNase PF01026.21 EMD60112.1 - 3.2e-53 180.7 0.0 3.7e-53 180.5 0.0 1.0 1 0 0 1 1 1 1 TatD related DNase Oxidored_q6 PF01058.22 EMD60113.1 - 1.6e-22 79.8 0.0 2.5e-22 79.1 0.0 1.3 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase, 20 Kd subunit Sedlin_N PF04628.13 EMD60114.1 - 1.8e-16 60.5 0.0 5e-16 59.0 0.0 1.6 1 1 0 1 1 1 1 Sedlin, N-terminal conserved region Sybindin PF04099.12 EMD60114.1 - 0.068 13.1 0.0 3.5 7.5 0.0 2.1 2 0 0 2 2 2 0 Sybindin-like family AFG1_ATPase PF03969.16 EMD60115.1 - 4.9e-62 209.9 0.6 2.8e-29 102.1 0.0 5.0 3 2 2 5 5 5 4 AFG1-like ATPase AAA_16 PF13191.6 EMD60115.1 - 8.5e-06 26.3 0.6 0.0019 18.6 0.1 3.1 2 1 0 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 EMD60115.1 - 0.00016 21.7 0.0 0.00058 19.9 0.0 1.9 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EMD60115.1 - 0.0017 18.6 0.0 0.005 17.1 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 EMD60115.1 - 0.018 14.8 0.0 0.05 13.3 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA PF00004.29 EMD60115.1 - 0.031 14.7 0.0 0.1 13.0 0.0 1.9 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 EMD60115.1 - 0.22 11.0 0.0 0.43 10.1 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region OTCace PF00185.24 EMD60116.1 - 9.5e-45 152.5 0.0 1.4e-44 151.9 0.0 1.3 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain OTCace_N PF02729.21 EMD60116.1 - 8.6e-43 145.9 0.1 1.4e-42 145.2 0.1 1.3 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain DUF3712 PF12505.8 EMD60117.1 - 0.00031 21.0 2.0 0.0022 18.3 0.1 3.3 5 1 0 5 5 5 1 Protein of unknown function (DUF3712) LEA_2 PF03168.13 EMD60117.1 - 0.019 15.5 2.1 9.9 6.8 0.2 4.6 5 0 0 5 5 5 0 Late embryogenesis abundant protein DUF1356 PF07092.12 EMD60117.1 - 0.23 10.7 2.2 1.7 7.8 1.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1356) HLH PF00010.26 EMD60118.1 - 4.1e-13 49.1 0.0 6.3e-13 48.5 0.0 1.3 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain IBR PF01485.21 EMD60119.1 - 6.1e-09 36.0 13.3 1.2e-05 25.4 9.3 2.1 2 0 0 2 2 2 2 IBR domain, a half RING-finger domain DUF647 PF04884.14 EMD60120.1 - 3.5e-112 373.9 3.5 4.5e-112 373.5 3.5 1.1 1 0 0 1 1 1 1 Vitamin B6 photo-protection and homoeostasis RGS PF00615.19 EMD60122.1 - 2.6e-10 40.6 0.0 7.1e-10 39.2 0.0 1.7 2 0 0 2 2 2 1 Regulator of G protein signaling domain SOG2 PF10428.9 EMD60124.1 - 7.9e-25 88.0 12.7 6.2e-15 55.4 1.2 3.4 3 1 1 4 4 4 2 RAM signalling pathway protein LRR_8 PF13855.6 EMD60124.1 - 2.8e-17 62.2 6.8 2.9e-09 36.5 0.2 2.9 1 1 2 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 EMD60124.1 - 1.3e-10 41.3 2.4 0.00019 21.7 0.0 3.9 1 1 2 3 3 3 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EMD60124.1 - 0.013 15.9 0.3 1.2e+02 3.9 0.0 4.9 4 0 0 4 4 4 0 Leucine Rich Repeat LRR_6 PF13516.6 EMD60124.1 - 0.17 12.0 7.4 5.3 7.4 0.0 4.8 6 0 0 6 6 6 0 Leucine Rich repeat DUF3135 PF11333.8 EMD60124.1 - 0.18 12.1 1.5 5.8 7.3 0.1 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3135) Fib_alpha PF08702.10 EMD60124.1 - 0.86 9.8 2.7 5.3 7.2 0.4 2.8 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family 60KD_IMP PF02096.20 EMD60125.1 - 3.5e-09 36.8 0.2 4.8e-09 36.3 0.2 1.1 1 0 0 1 1 1 1 60Kd inner membrane protein ALG11_N PF15924.5 EMD60126.1 - 7.4e-82 274.4 0.0 1e-81 274.0 0.0 1.2 1 0 0 1 1 1 1 ALG11 mannosyltransferase N-terminus Glycos_transf_1 PF00534.20 EMD60126.1 - 1.7e-22 79.7 0.0 2.9e-22 79.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EMD60126.1 - 4.9e-10 40.0 0.0 1.1e-09 38.8 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 EMD60126.1 - 0.0041 17.1 0.0 0.0091 16.0 0.0 1.6 1 0 0 1 1 1 1 Glycosyltransferase Family 4 CDC45 PF02724.14 EMD60127.1 - 2.6 6.2 4.8 4.6 5.4 4.8 1.3 1 0 0 1 1 1 0 CDC45-like protein Mur_ligase_M PF08245.12 EMD60128.1 - 1.5e-07 31.6 0.0 2.8e-07 30.7 0.0 1.4 1 0 0 1 1 1 1 Mur ligase middle domain Mur_ligase_C PF02875.21 EMD60128.1 - 0.0044 17.2 0.0 0.042 14.1 0.0 2.3 2 0 0 2 2 2 1 Mur ligase family, glutamate ligase domain Dscam_C PF12355.8 EMD60130.1 - 0.16 12.9 0.2 0.24 12.4 0.2 1.2 1 0 0 1 1 1 0 Down syndrome cell adhesion molecule C terminal FAD_binding_4 PF01565.23 EMD60131.1 - 7.4e-20 71.1 6.3 1.3e-19 70.3 6.3 1.4 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EMD60131.1 - 8.1e-05 22.6 0.1 0.0002 21.4 0.1 1.6 1 0 0 1 1 1 1 Berberine and berberine like NPCC PF08058.11 EMD60131.1 - 0.1 12.7 0.0 0.23 11.5 0.0 1.6 1 0 0 1 1 1 0 Nuclear pore complex component Alba PF01918.21 EMD60132.1 - 0.068 13.0 0.1 0.14 12.0 0.1 1.5 1 0 0 1 1 1 0 Alba TMEM156 PF15106.6 EMD60133.1 - 0.069 12.6 0.0 0.095 12.1 0.0 1.2 1 0 0 1 1 1 0 TMEM156 protein family ACOX PF01756.19 EMD60134.1 - 5.2e-43 146.7 0.4 1.5e-42 145.2 0.1 1.9 2 0 0 2 2 2 1 Acyl-CoA oxidase Acyl-CoA_ox_N PF14749.6 EMD60134.1 - 2.7e-27 95.8 0.8 7.4e-27 94.4 0.8 1.8 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_M PF02770.19 EMD60134.1 - 7.7e-12 45.3 0.0 1.9e-11 44.0 0.0 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.24 EMD60134.1 - 5.7e-06 26.6 0.0 0.0085 16.3 0.0 2.6 2 0 0 2 2 2 2 Acyl-CoA dehydrogenase, C-terminal domain PP2C PF00481.21 EMD60135.1 - 1.2e-81 274.2 0.0 1.9e-81 273.5 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C FMN_dh PF01070.18 EMD60136.1 - 6.1e-107 357.6 0.1 7.2e-107 357.4 0.1 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase IMPDH PF00478.25 EMD60136.1 - 9.4e-05 21.6 0.8 0.00017 20.7 0.8 1.5 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain His_biosynth PF00977.21 EMD60136.1 - 0.0028 17.2 0.2 0.028 13.9 0.2 2.1 1 1 1 2 2 2 1 Histidine biosynthesis protein Glu_synthase PF01645.17 EMD60136.1 - 0.0038 16.4 0.1 0.0054 15.9 0.1 1.1 1 0 0 1 1 1 1 Conserved region in glutamate synthase ThiG PF05690.14 EMD60136.1 - 0.0058 16.0 0.3 1.3 8.3 0.1 2.5 1 1 1 2 2 2 2 Thiazole biosynthesis protein ThiG WD40 PF00400.32 EMD60137.1 - 2.1e-37 126.5 25.2 3.5e-10 40.3 0.5 7.9 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD60137.1 - 5e-11 42.7 0.8 0.0058 16.9 0.1 5.2 2 1 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EMD60137.1 - 3e-07 29.5 5.9 0.28 9.8 0.2 4.8 3 2 1 5 5 5 4 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 EMD60137.1 - 1.1e-06 27.9 0.5 0.7 8.8 0.0 4.2 2 2 1 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein PALB2_WD40 PF16756.5 EMD60137.1 - 9.4e-05 21.5 0.1 9.4e-05 21.5 0.1 2.5 3 1 0 3 3 3 1 Partner and localizer of BRCA2 WD40 domain Frtz PF11768.8 EMD60137.1 - 0.0032 15.9 0.0 0.0059 15.0 0.0 1.5 1 0 0 1 1 1 1 WD repeat-containing and planar cell polarity effector protein Fritz Nucleoporin_N PF08801.11 EMD60137.1 - 0.005 15.6 0.1 1.1 7.9 0.1 2.8 1 1 1 3 3 3 2 Nup133 N terminal like Hira PF07569.11 EMD60137.1 - 0.014 15.1 0.7 3.8 7.2 0.1 3.1 1 1 1 2 2 2 0 TUP1-like enhancer of split Coatomer_WDAD PF04053.14 EMD60137.1 - 0.028 13.5 0.0 0.036 13.1 0.0 1.2 1 0 0 1 1 1 0 Coatomer WD associated region AIP3 PF03915.13 EMD60138.1 - 2.6e-152 507.6 15.1 4.7e-152 506.8 15.1 1.4 1 0 0 1 1 1 1 Actin interacting protein 3 Lectin_N PF03954.14 EMD60138.1 - 0.16 11.7 2.4 0.4 10.4 0.1 2.8 2 0 0 2 2 2 0 Hepatic lectin, N-terminal domain LsmAD PF06741.13 EMD60139.1 - 1.7e-28 98.9 4.0 6.2e-28 97.2 4.0 2.1 1 0 0 1 1 1 1 LsmAD domain SM-ATX PF14438.6 EMD60139.1 - 8.6e-16 57.9 0.1 2.7e-15 56.3 0.0 1.9 2 0 0 2 2 2 1 Ataxin 2 SM domain Sugar_tr PF00083.24 EMD60140.1 - 1.9e-97 327.0 17.7 3.5e-97 326.1 17.7 1.4 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD60140.1 - 2.7e-27 95.6 29.2 4e-27 95.1 29.2 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 EMD60140.1 - 1.6e-05 23.6 3.0 1.6e-05 23.6 3.0 2.1 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) MFS_1_like PF12832.7 EMD60140.1 - 0.003 16.5 5.2 0.073 11.9 0.1 2.9 2 1 0 3 3 3 1 MFS_1 like family LacY_symp PF01306.19 EMD60140.1 - 0.0055 15.5 11.2 0.025 13.4 2.1 2.4 2 0 0 2 2 2 2 LacY proton/sugar symporter MFS_3 PF05977.13 EMD60140.1 - 0.019 13.3 10.1 0.026 13.0 2.5 2.4 2 0 0 2 2 2 0 Transmembrane secretion effector Abhydrolase_1 PF00561.20 EMD60141.1 - 5.9e-16 58.9 0.3 1.2e-14 54.6 0.3 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EMD60141.1 - 1.8e-07 32.0 0.1 2.3e-07 31.6 0.1 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EMD60141.1 - 4.7e-06 26.0 0.1 1.3e-05 24.6 0.1 1.8 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_4 PF08386.10 EMD60141.1 - 0.011 15.8 0.0 0.023 14.8 0.0 1.5 1 0 0 1 1 1 0 TAP-like protein Esterase PF00756.20 EMD60141.1 - 0.012 15.2 0.0 0.015 15.0 0.0 1.3 1 0 0 1 1 1 0 Putative esterase Peptidase_S9 PF00326.21 EMD60141.1 - 0.016 14.7 0.7 0.52 9.7 0.1 2.2 2 0 0 2 2 2 0 Prolyl oligopeptidase family CitF PF04223.12 EMD60141.1 - 0.077 11.9 0.0 0.1 11.5 0.0 1.1 1 0 0 1 1 1 0 Citrate lyase, alpha subunit (CitF) PGAP1 PF07819.13 EMD60141.1 - 0.082 12.6 0.1 0.17 11.5 0.0 1.5 2 0 0 2 2 2 0 PGAP1-like protein DLH PF01738.18 EMD60141.1 - 0.1 12.1 0.1 12 5.4 0.0 2.2 2 0 0 2 2 2 0 Dienelactone hydrolase family DUF915 PF06028.11 EMD60141.1 - 0.12 11.6 0.0 0.4 10.0 0.0 1.8 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF915) HET PF06985.11 EMD60142.1 - 3.6e-31 108.5 0.0 5.9e-31 107.8 0.0 1.3 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) F-box-like_2 PF13013.6 EMD60142.1 - 0.047 13.7 0.1 2.7 8.0 0.0 2.5 2 0 0 2 2 2 0 F-box-like domain baeRF_family11 PF18855.1 EMD60143.1 - 0.097 13.0 0.0 10 6.5 0.0 2.3 2 0 0 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 11 PPTA PF01239.22 EMD60144.1 - 5.4e-08 32.3 5.8 0.00012 21.7 0.1 4.6 5 0 0 5 5 5 3 Protein prenyltransferase alpha subunit repeat CHD5 PF04420.14 EMD60145.1 - 2.1e-58 196.7 1.8 2.4e-58 196.5 0.4 1.6 2 0 0 2 2 2 1 CHD5-like protein DUF2749 PF10907.8 EMD60145.1 - 0.0038 17.4 0.1 0.33 11.1 0.3 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF2749) NADH_dh_m_C1 PF15088.6 EMD60145.1 - 0.083 12.5 0.1 0.29 10.8 0.0 1.9 2 0 0 2 2 2 0 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial MFS_1 PF07690.16 EMD60146.1 - 3.3e-13 49.3 26.8 3.3e-13 49.3 26.8 3.3 2 2 1 3 3 3 1 Major Facilitator Superfamily LapA_dom PF06305.11 EMD60146.1 - 6.1 6.7 5.5 3.4 7.5 0.0 3.4 3 0 0 3 3 3 0 Lipopolysaccharide assembly protein A domain DUF1689 PF07954.11 EMD60148.1 - 0.018 15.4 0.1 0.022 15.1 0.1 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1689) Romo1 PF10247.9 EMD60148.1 - 0.026 14.9 1.1 5.8 7.4 0.2 2.6 2 0 0 2 2 2 0 Reactive mitochondrial oxygen species modulator 1 PP2C PF00481.21 EMD60149.1 - 1.3e-40 139.7 0.0 2e-40 139.0 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 EMD60149.1 - 0.0023 17.6 0.0 0.005 16.5 0.0 1.6 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 EMD60149.1 - 0.03 14.2 0.1 0.53 10.2 0.0 2.5 3 0 0 3 3 3 0 Stage II sporulation protein E (SpoIIE) Tcf25 PF04910.14 EMD60150.1 - 7.5e-79 265.3 0.0 1e-78 264.9 0.0 1.2 1 0 0 1 1 1 1 Transcriptional repressor TCF25 Wbp11 PF09429.10 EMD60150.1 - 0.0074 16.7 5.8 0.029 14.8 5.8 2.0 1 0 0 1 1 1 1 WW domain binding protein 11 Nop53 PF07767.11 EMD60150.1 - 0.019 14.4 10.4 0.036 13.4 10.4 1.5 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) TPR_6 PF13174.6 EMD60150.1 - 0.11 13.1 1.1 0.35 11.6 0.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat SPT6_acidic PF14632.6 EMD60150.1 - 0.17 12.5 10.1 0.55 10.9 10.1 1.8 1 0 0 1 1 1 0 Acidic N-terminal SPT6 PrsW-protease PF13367.6 EMD60150.1 - 0.22 11.0 0.0 0.33 10.4 0.0 1.2 1 0 0 1 1 1 0 PrsW family intramembrane metalloprotease HNF-1_N PF04814.13 EMD60150.1 - 0.31 11.7 4.9 4.2 8.0 0.0 2.4 2 0 0 2 2 2 0 Hepatocyte nuclear factor 1 (HNF-1), N terminus eIF3_subunit PF08597.10 EMD60150.1 - 1.3 8.8 16.2 2.4 8.0 16.2 1.4 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit CDC45 PF02724.14 EMD60150.1 - 2.5 6.3 8.8 3.7 5.7 8.8 1.2 1 0 0 1 1 1 0 CDC45-like protein CRAL_TRIO_2 PF13716.6 EMD60151.1 - 7.4e-37 126.6 0.0 1.2e-36 125.9 0.0 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain RhoGAP PF00620.27 EMD60151.1 - 1.4e-19 70.5 0.0 2.8e-19 69.5 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain CRAL_TRIO PF00650.20 EMD60151.1 - 7.7e-06 25.7 0.0 1.4e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain Fungal_trans PF04082.18 EMD60152.1 - 4.2e-26 91.6 0.5 4.2e-26 91.6 0.5 2.2 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD60152.1 - 1.1e-07 31.8 9.0 2.1e-07 30.9 9.0 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Collagen PF01391.18 EMD60152.1 - 0.41 10.4 5.1 0.97 9.2 5.1 1.5 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) Chorismate_synt PF01264.21 EMD60153.1 - 7.5e-138 458.7 0.0 8.6e-138 458.5 0.0 1.0 1 0 0 1 1 1 1 Chorismate synthase Porin_3 PF01459.22 EMD60154.1 - 1.3e-65 221.6 7.0 1.5e-65 221.4 7.0 1.0 1 0 0 1 1 1 1 Eukaryotic porin MspA PF09203.11 EMD60154.1 - 0.011 15.6 1.4 0.011 15.6 1.4 1.9 2 1 0 2 2 2 0 MspA DnaJ PF00226.31 EMD60155.1 - 2.6e-20 72.3 1.0 4.1e-20 71.7 1.0 1.3 1 0 0 1 1 1 1 DnaJ domain Peptidase_M24 PF00557.24 EMD60156.1 - 3.1e-44 151.2 0.1 4e-44 150.8 0.1 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 Pectinesterase PF01095.19 EMD60156.1 - 0.00022 20.1 0.1 0.00035 19.4 0.1 1.2 1 0 0 1 1 1 1 Pectinesterase Med3 PF11593.8 EMD60156.1 - 0.15 11.2 3.8 0.23 10.6 3.8 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal YL1 PF05764.13 EMD60156.1 - 0.2 11.8 8.6 0.29 11.2 8.6 1.2 1 0 0 1 1 1 0 YL1 nuclear protein CCDC106 PF15794.5 EMD60156.1 - 0.47 10.1 3.5 0.79 9.4 3.5 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 DUF3381 PF11861.8 EMD60156.1 - 1.5 8.6 6.3 3.4 7.5 6.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) CDC45 PF02724.14 EMD60156.1 - 3.5 5.8 7.8 5.1 5.3 7.8 1.1 1 0 0 1 1 1 0 CDC45-like protein Methyltransf_16 PF10294.9 EMD60157.1 - 1.7e-45 154.9 0.0 2.1e-45 154.6 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase DUF43 PF01861.16 EMD60157.1 - 0.00038 19.8 0.0 0.00049 19.4 0.0 1.1 1 0 0 1 1 1 1 Branched-chain polyamine synthase A C-terminal domain Ammonium_transp PF00909.21 EMD60158.1 - 1.1e-66 225.2 21.9 1.2e-66 225.0 21.9 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family Rhodanese PF00581.20 EMD60159.1 - 8.5e-08 32.7 0.0 1.6e-07 31.8 0.0 1.5 1 1 0 1 1 1 1 Rhodanese-like domain UBA PF00627.31 EMD60159.1 - 0.21 11.6 0.5 0.37 10.7 0.0 1.7 2 0 0 2 2 2 0 UBA/TS-N domain RasGEF PF00617.19 EMD60161.1 - 1.2e-52 178.7 0.6 3e-52 177.4 0.1 2.0 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 EMD60161.1 - 2.6e-15 56.6 0.0 1.1e-14 54.5 0.0 2.1 1 0 0 1 1 1 1 RasGEF N-terminal motif SH3_9 PF14604.6 EMD60161.1 - 6.3e-05 22.8 0.1 0.00028 20.7 0.0 2.1 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.28 EMD60161.1 - 0.00037 20.0 0.0 0.001 18.6 0.0 1.8 2 0 0 2 2 2 1 SH3 domain DUF4846 PF16138.5 EMD60161.1 - 0.083 12.4 0.0 0.16 11.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (4846) Sld5 PF05916.11 EMD60163.1 - 2.8e-32 111.4 0.0 5.3e-32 110.5 0.0 1.4 1 0 0 1 1 1 1 GINS complex protein DIE2_ALG10 PF04922.12 EMD60164.1 - 1.3e-127 426.4 6.6 1.3e-127 426.4 6.6 1.4 2 0 0 2 2 2 1 DIE2/ALG10 family DUF202 PF02656.15 EMD60165.1 - 2.3e-14 53.6 6.6 4.2e-14 52.7 3.7 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF202) Tctex-1 PF03645.13 EMD60166.1 - 6.2e-33 113.1 0.3 7e-33 112.9 0.3 1.0 1 0 0 1 1 1 1 Tctex-1 family bZIP_2 PF07716.15 EMD60167.1 - 1.4e-10 41.1 13.5 1.4e-10 41.1 13.5 1.7 2 0 0 2 2 1 1 Basic region leucine zipper CLZ PF16526.5 EMD60167.1 - 0.0027 18.0 2.0 0.0064 16.8 2.0 1.6 1 0 0 1 1 1 1 C-terminal leucine zipper domain of cyclic nucleotide-gated channels CREPT PF16566.5 EMD60167.1 - 0.0027 17.9 1.7 0.0041 17.3 1.7 1.3 1 0 0 1 1 1 1 Cell-cycle alteration and expression-elevated protein in tumour LCD1 PF09798.9 EMD60167.1 - 0.0059 15.2 0.1 0.0059 15.2 0.1 1.2 1 0 0 1 1 1 1 DNA damage checkpoint protein bZIP_1 PF00170.21 EMD60167.1 - 0.016 15.3 9.9 0.039 14.0 9.9 1.6 1 0 0 1 1 1 0 bZIP transcription factor TSC22 PF01166.18 EMD60167.1 - 0.032 14.5 1.7 0.034 14.4 0.3 1.7 2 0 0 2 2 2 0 TSC-22/dip/bun family DUF4115 PF13464.6 EMD60167.1 - 0.072 13.3 0.0 0.16 12.1 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4115) DUF5094 PF17015.5 EMD60167.1 - 0.1 12.7 2.9 0.15 12.2 2.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5094) DDE_Tnp_1 PF01609.21 EMD60167.1 - 0.11 12.2 0.8 0.14 11.8 0.8 1.1 1 0 0 1 1 1 0 Transposase DDE domain DivIC PF04977.15 EMD60167.1 - 0.15 11.8 4.7 0.4 10.5 4.5 1.8 1 1 0 1 1 1 0 Septum formation initiator NapB PF03892.14 EMD60167.1 - 0.16 12.0 2.1 0.23 11.5 0.1 2.1 1 1 1 2 2 2 0 Nitrate reductase cytochrome c-type subunit (NapB) XhlA PF10779.9 EMD60167.1 - 0.23 11.7 4.4 0.56 10.5 4.4 1.6 1 0 0 1 1 1 0 Haemolysin XhlA FAM76 PF16046.5 EMD60167.1 - 0.24 10.7 5.7 0.41 10.0 5.7 1.3 1 0 0 1 1 1 0 FAM76 protein bZIP_Maf PF03131.17 EMD60167.1 - 0.39 11.3 10.8 0.2 12.2 8.0 1.9 2 0 0 2 2 2 0 bZIP Maf transcription factor YabA PF06156.13 EMD60167.1 - 2.7 8.7 6.0 10 6.8 1.7 2.1 1 1 1 2 2 2 0 Initiation control protein YabA V_ATPase_I PF01496.19 EMD60167.1 - 2.8 5.8 5.2 3.4 5.5 5.2 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CENP-N PF05238.13 EMD60168.1 - 2.8e-135 451.8 0.0 3.2e-135 451.7 0.0 1.0 1 0 0 1 1 1 1 Kinetochore protein CHL4 like SUR7 PF06687.12 EMD60170.1 - 1.1e-39 136.3 21.6 1.3e-39 136.1 21.6 1.1 1 0 0 1 1 1 1 SUR7/PalI family ETRAMP PF09716.10 EMD60170.1 - 3.7 7.7 0.0 3.7 7.7 0.0 2.8 3 0 0 3 3 3 0 Malarial early transcribed membrane protein (ETRAMP) SKG6 PF08693.10 EMD60171.1 - 0.16 11.4 7.3 0.36 10.3 7.3 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain PPI_Ypi1 PF07491.11 EMD60172.1 - 1.1e-23 82.7 9.5 1.1e-23 82.7 9.5 2.3 2 1 0 2 2 2 1 Protein phosphatase inhibitor SURF2 PF05477.11 EMD60172.1 - 0.018 14.8 4.5 0.02 14.6 4.5 1.1 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) CDC45 PF02724.14 EMD60172.1 - 0.25 9.6 5.4 0.27 9.5 5.4 1.0 1 0 0 1 1 1 0 CDC45-like protein DASH_Dad2 PF08654.10 EMD60173.1 - 4e-34 117.0 0.3 5.2e-34 116.6 0.3 1.1 1 0 0 1 1 1 1 DASH complex subunit Dad2 Shugoshin_N PF07558.11 EMD60174.1 - 1.6e-19 69.5 7.9 2.4e-19 68.9 5.9 2.4 2 0 0 2 2 2 1 Shugoshin N-terminal coiled-coil region Shugoshin_C PF07557.11 EMD60174.1 - 2.5e-12 46.4 7.6 5e-12 45.4 5.7 2.8 2 0 0 2 2 2 1 Shugoshin C terminus zf-C2H2 PF00096.26 EMD60177.1 - 1.3e-12 47.5 12.5 3.7e-06 27.1 2.4 3.8 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMD60177.1 - 1.4e-12 47.4 10.0 7.5e-08 32.5 0.2 3.7 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMD60177.1 - 1.2e-08 35.1 10.6 0.00041 20.9 1.5 3.8 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EMD60177.1 - 3.5e-08 33.2 5.8 0.00033 20.6 0.3 3.5 3 0 0 3 3 3 2 C2H2-type zinc finger zf-met PF12874.7 EMD60177.1 - 3.1e-05 24.2 0.9 0.013 15.8 0.2 3.1 3 0 0 3 3 3 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EMD60177.1 - 6.9e-05 23.0 4.3 0.089 13.1 0.1 3.9 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding Zn_ribbon_recom PF13408.6 EMD60177.1 - 0.0056 17.2 1.2 0.013 16.0 1.2 1.5 1 0 0 1 1 1 1 Recombinase zinc beta ribbon domain zf-C2H2_11 PF16622.5 EMD60177.1 - 0.021 14.6 5.4 0.42 10.4 0.7 3.2 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-Di19 PF05605.12 EMD60177.1 - 0.045 14.1 1.4 0.089 13.1 1.4 1.5 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding LIM PF00412.22 EMD60177.1 - 0.43 10.8 3.0 17 5.8 0.2 2.4 1 1 1 2 2 2 0 LIM domain C5HCH PF17982.1 EMD60177.1 - 6.6 7.0 6.6 19 5.5 1.6 2.6 1 1 1 2 2 2 0 NSD Cys-His rich domain BRO1 PF03097.18 EMD60178.1 - 2.1e-125 418.6 4.6 1.4e-124 415.8 0.0 2.5 2 1 0 2 2 2 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.6 EMD60178.1 - 2.4e-83 279.9 9.5 2.4e-83 279.9 9.5 2.1 2 0 0 2 2 2 1 ALIX V-shaped domain binding to HIV Cytadhesin_P30 PF07271.11 EMD60178.1 - 0.00012 21.8 0.8 0.00022 20.9 0.8 1.3 1 0 0 1 1 1 1 Cytadhesin P30/P32 SpoU_sub_bind PF08032.12 EMD60178.1 - 0.45 10.8 2.7 36 4.7 0.0 3.5 3 0 0 3 3 3 0 RNA 2'-O ribose methyltransferase substrate binding Sec8_exocyst PF04048.14 EMD60178.1 - 8.4 6.3 10.0 17 5.3 0.7 3.8 3 1 0 3 3 3 0 Sec8 exocyst complex component specific domain HMA PF00403.26 EMD60179.1 - 1.4e-16 60.7 0.4 1.7e-16 60.4 0.4 1.1 1 0 0 1 1 1 1 Heavy-metal-associated domain DUF211 PF02680.14 EMD60179.1 - 0.008 16.3 0.2 0.015 15.4 0.2 1.4 1 1 0 1 1 1 1 Uncharacterized ArCR, COG1888 Fer2_BFD PF04324.15 EMD60179.1 - 0.084 13.2 0.2 0.18 12.2 0.1 1.6 2 0 0 2 2 2 0 BFD-like [2Fe-2S] binding domain DJ-1_PfpI PF01965.24 EMD60180.1 - 0.0011 18.9 0.0 0.0014 18.5 0.0 1.2 1 0 0 1 1 1 1 DJ-1/PfpI family Glyoxalase_3 PF13468.6 EMD60183.1 - 3.5e-26 92.4 0.0 5.7e-26 91.7 0.0 1.3 1 0 0 1 1 1 1 Glyoxalase-like domain Fungal_trans PF04082.18 EMD60184.1 - 1.6e-11 43.8 2.9 2.9e-11 42.9 2.9 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD60184.1 - 1.3e-07 31.7 11.3 2.1e-07 30.9 11.3 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Delta_lysin PF05372.11 EMD60184.1 - 0.11 11.8 0.0 0.28 10.5 0.0 1.6 1 0 0 1 1 1 0 Delta lysin family Neisseria_TspB PF05616.13 EMD60184.1 - 0.74 8.2 2.3 1.1 7.6 2.3 1.1 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein Rep_fac-A_C PF08646.10 EMD60184.1 - 6.3 6.5 5.9 14 5.4 5.9 1.5 1 0 0 1 1 1 0 Replication factor-A C terminal domain SIR2 PF02146.17 EMD60185.1 - 2.3e-38 131.9 0.0 5.1e-38 130.8 0.0 1.5 1 1 0 1 1 1 1 Sir2 family Peptidase_M24 PF00557.24 EMD60186.1 - 3.5e-54 183.7 0.0 5.4e-54 183.1 0.0 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 EMD60186.1 - 8.3e-35 119.2 0.0 1.4e-34 118.5 0.0 1.4 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain PNP_UDP_1 PF01048.20 EMD60187.1 - 9.9e-10 38.1 1.1 1e-08 34.7 1.1 2.0 1 1 0 1 1 1 1 Phosphorylase superfamily Tyrosinase PF00264.20 EMD60188.1 - 2.7e-42 145.5 0.3 3.8e-42 145.1 0.3 1.2 1 0 0 1 1 1 1 Common central domain of tyrosinase FAD-oxidase_C PF02913.19 EMD60190.1 - 2.6e-48 164.8 0.0 3.3e-48 164.5 0.0 1.1 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 EMD60190.1 - 3e-31 108.0 0.0 8.2e-31 106.6 0.0 1.7 2 0 0 2 2 2 1 FAD binding domain Gln-synt_C PF00120.24 EMD60192.1 - 4.7e-20 71.9 0.0 3.9e-19 68.8 0.0 2.0 1 1 0 1 1 1 1 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.19 EMD60192.1 - 2.4e-14 52.8 0.0 4.9e-14 51.8 0.0 1.5 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain Med1 PF10744.9 EMD60193.1 - 8.9e-80 268.7 0.0 1.2e-79 268.3 0.0 1.2 1 0 0 1 1 1 1 Mediator of RNA polymerase II transcription subunit 1 TPR_10 PF13374.6 EMD60193.1 - 0.026 14.4 0.1 0.43 10.5 0.1 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat ZF-HD_dimer PF04770.12 EMD60194.1 - 0.31 11.4 5.1 0.57 10.6 4.3 1.7 1 1 1 2 2 2 0 ZF-HD protein dimerisation region GFA PF04828.14 EMD60195.1 - 6.8e-19 68.0 0.6 1.2e-18 67.2 0.6 1.4 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme Zn_ribbon_recom PF13408.6 EMD60195.1 - 0.029 14.9 0.1 0.029 14.9 0.1 2.6 2 1 1 3 3 3 0 Recombinase zinc beta ribbon domain Tfb5 PF06331.12 EMD60196.1 - 6.7e-24 83.7 1.9 7.3e-24 83.5 1.9 1.0 1 0 0 1 1 1 1 Transcription factor TFIIH complex subunit Tfb5 Med4 PF10018.9 EMD60196.1 - 0.0012 18.6 1.9 0.0012 18.6 1.9 1.0 1 0 0 1 1 1 1 Vitamin-D-receptor interacting Mediator subunit 4 Citrate_ly_lig PF08218.11 EMD60196.1 - 0.053 13.2 0.1 0.06 13.0 0.1 1.0 1 0 0 1 1 1 0 Citrate lyase ligase C-terminal domain CobS_N PF12556.8 EMD60197.1 - 0.018 14.8 0.1 0.03 14.0 0.1 1.4 1 0 0 1 1 1 0 Cobaltochelatase CobS subunit N terminal DUF4381 PF14316.6 EMD60197.1 - 0.096 12.9 0.0 0.16 12.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) MFS_1 PF07690.16 EMD60199.1 - 7.3e-34 117.2 48.4 7.3e-34 117.2 48.4 2.3 2 1 0 2 2 2 1 Major Facilitator Superfamily Chitin_synth_2 PF03142.15 EMD60199.1 - 4.6 5.7 4.9 0.38 9.3 0.3 1.4 2 0 0 2 2 2 0 Chitin synthase Isochorismatase PF00857.20 EMD60200.1 - 1.9e-30 106.3 0.1 1e-27 97.4 0.0 3.1 2 1 0 2 2 2 1 Isochorismatase family 2OG-FeII_Oxy_2 PF13532.6 EMD60200.1 - 7e-26 91.6 0.1 1.7e-25 90.4 0.1 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily GST_C_2 PF13410.6 EMD60200.1 - 5.9e-06 26.2 0.2 1.3e-05 25.1 0.2 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EMD60200.1 - 0.002 18.3 0.0 0.0072 16.5 0.0 1.9 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EMD60200.1 - 0.0038 17.4 0.0 0.013 15.7 0.0 1.9 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain SRAP PF02586.14 EMD60201.1 - 7.6e-86 287.2 0.0 1.1e-85 286.7 0.0 1.2 1 0 0 1 1 1 1 SOS response associated peptidase (SRAP) DUF908 PF06012.12 EMD60201.1 - 0.14 11.5 4.9 0.25 10.7 4.9 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) TPR_12 PF13424.6 EMD60202.1 - 4.4e-05 23.7 3.8 0.027 14.8 1.6 3.9 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 EMD60202.1 - 0.0027 17.7 12.3 0.074 13.2 0.5 4.6 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.6 EMD60202.1 - 0.0029 17.5 0.7 3.3 8.0 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat RPN7 PF10602.9 EMD60202.1 - 0.0029 17.3 0.2 1.2 8.8 0.3 3.2 3 0 0 3 3 3 1 26S proteasome subunit RPN7 TPR_14 PF13428.6 EMD60202.1 - 0.0047 17.6 2.1 2.2 9.3 0.2 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_MalT PF17874.1 EMD60202.1 - 0.079 12.3 1.2 1.5 8.1 0.6 2.4 2 0 0 2 2 2 0 MalT-like TPR region TPR_10 PF13374.6 EMD60202.1 - 0.59 10.1 2.9 1.2 9.1 0.3 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat RabGAP-TBC PF00566.18 EMD60203.1 - 2.1e-51 174.6 4.4 5.6e-51 173.2 0.0 3.0 3 0 0 3 3 3 1 Rab-GTPase-TBC domain ZapB PF06005.12 EMD60203.1 - 0.021 15.2 3.9 0.021 15.2 3.9 4.1 3 1 0 3 3 3 0 Cell division protein ZapB USP8_interact PF08941.10 EMD60203.1 - 6 6.6 8.5 1.1 9.0 0.9 2.5 2 0 0 2 2 2 0 USP8 interacting Aa_trans PF01490.18 EMD60206.1 - 5.1e-51 173.7 37.0 5.8e-51 173.5 37.0 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Tetraspanin PF00335.20 EMD60206.1 - 0.1 12.3 0.1 0.1 12.3 0.1 3.5 3 1 1 4 4 4 0 Tetraspanin family His_Phos_1 PF00300.22 EMD60207.1 - 2.8e-19 69.6 0.3 1.4e-17 64.0 0.3 2.1 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) DAO PF01266.24 EMD60208.1 - 1.2e-31 110.6 0.1 1.5e-31 110.3 0.1 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EMD60208.1 - 3.9e-06 26.9 0.1 0.0051 16.8 0.0 2.6 2 0 0 2 2 2 2 FAD-NAD(P)-binding Trp_halogenase PF04820.14 EMD60208.1 - 4.2e-06 25.9 0.1 0.18 10.6 0.0 3.0 3 0 0 3 3 3 2 Tryptophan halogenase Pyr_redox_2 PF07992.14 EMD60208.1 - 1.6e-05 24.3 0.0 0.00018 20.8 0.0 2.0 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EMD60208.1 - 0.0011 19.2 0.0 0.0028 17.8 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Sacchrp_dh_NADP PF03435.18 EMD60208.1 - 0.0011 19.2 0.0 0.0023 18.2 0.0 1.5 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain FAD_binding_3 PF01494.19 EMD60208.1 - 0.022 14.0 0.0 0.035 13.3 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain TrkA_N PF02254.18 EMD60208.1 - 0.029 14.6 0.0 0.057 13.7 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain Shikimate_DH PF01488.20 EMD60208.1 - 0.03 14.4 0.0 0.061 13.4 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase ApbA PF02558.16 EMD60208.1 - 0.072 12.7 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA GIDA PF01134.22 EMD60208.1 - 0.11 11.6 0.0 1.7 7.7 0.0 2.1 2 0 0 2 2 2 0 Glucose inhibited division protein A Pyr_redox PF00070.27 EMD60208.1 - 0.13 12.8 0.0 0.4 11.3 0.0 1.8 2 0 0 2 2 1 0 Pyridine nucleotide-disulphide oxidoreductase ADH_zinc_N PF00107.26 EMD60209.1 - 1.5e-27 96.1 0.1 7.2e-27 93.9 0.0 2.1 3 0 0 3 3 3 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EMD60209.1 - 1.1e-21 78.2 0.0 3.5e-21 76.6 0.0 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EMD60209.1 - 4.7e-05 23.2 0.0 0.0001 22.1 0.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain AlaDh_PNT_C PF01262.21 EMD60209.1 - 0.01 15.2 0.3 0.017 14.5 0.3 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain ADH_N_2 PF16884.5 EMD60209.1 - 0.043 13.7 0.0 0.091 12.7 0.0 1.6 1 0 0 1 1 1 0 N-terminal domain of oxidoreductase Cpn10 PF00166.21 EMD60209.1 - 0.1 12.6 0.2 0.35 11.0 0.0 2.0 2 0 0 2 2 2 0 Chaperonin 10 Kd subunit SPT6_acidic PF14632.6 EMD60212.1 - 0.26 11.9 11.4 0.16 12.5 3.9 2.7 2 0 0 2 2 2 0 Acidic N-terminal SPT6 SAPS PF04499.15 EMD60212.1 - 8.8 5.0 8.7 1.3 7.8 1.7 2.1 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein DUF4611 PF15387.6 EMD60212.1 - 9 6.6 13.8 6.1 7.1 3.9 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) UME PF08064.13 EMD60213.1 - 0.0032 17.3 0.3 0.0049 16.8 0.3 1.2 1 0 0 1 1 1 1 UME (NUC010) domain DUF664 PF04978.12 EMD60213.1 - 0.016 15.6 0.4 0.034 14.6 0.4 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF664) DUF1484 PF07363.11 EMD60213.1 - 1.7 9.7 7.1 0.44 11.6 3.8 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1484) F-box PF00646.33 EMD60215.1 - 0.084 12.8 0.9 0.23 11.4 0.0 2.1 2 0 0 2 2 2 0 F-box domain GIY-YIG PF01541.24 EMD60215.1 - 0.11 12.7 0.1 0.72 10.2 0.0 2.3 2 0 0 2 2 2 0 GIY-YIG catalytic domain DUF4407 PF14362.6 EMD60215.1 - 1.8 7.8 7.2 11 5.2 4.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Phage_GP20 PF06810.11 EMD60217.1 - 0.014 15.2 8.9 1 9.2 1.6 2.5 1 1 1 2 2 2 0 Phage minor structural protein GP20 LsmAD PF06741.13 EMD60217.1 - 2.9 8.5 6.2 8.9 6.9 0.4 3.0 3 0 0 3 3 3 0 LsmAD domain MFS_1 PF07690.16 EMD60218.1 - 4e-15 55.6 54.6 3.9e-07 29.3 18.3 3.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EMD60218.1 - 3.9e-08 32.2 12.5 5.9e-08 31.6 12.5 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF1189 PF06691.11 EMD60218.1 - 0.00081 19.0 0.9 0.00081 19.0 0.9 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1189) UL42 PF17638.2 EMD60218.1 - 0.023 14.7 2.5 0.27 11.2 0.0 2.6 2 0 0 2 2 2 0 HCMV UL42 Methyltransf_23 PF13489.6 EMD60220.1 - 2e-19 70.0 0.0 2.9e-19 69.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMD60220.1 - 9.2e-16 58.3 0.0 1.4e-15 57.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMD60220.1 - 3.4e-12 46.9 0.0 5.6e-12 46.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMD60220.1 - 9.6e-12 45.5 0.0 1.4e-11 45.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMD60220.1 - 1.7e-11 44.1 0.0 2.2e-11 43.8 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.11 EMD60220.1 - 3.8e-06 26.1 0.0 6.1e-06 25.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) PrmA PF06325.13 EMD60220.1 - 4.8e-05 22.9 0.0 8e-05 22.2 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Ubie_methyltran PF01209.18 EMD60220.1 - 0.025 13.9 0.0 0.034 13.5 0.0 1.1 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family MTS PF05175.14 EMD60220.1 - 0.027 14.0 0.0 0.043 13.4 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain CMAS PF02353.20 EMD60220.1 - 0.048 13.0 0.0 0.11 11.7 0.0 1.5 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase MRP-L27 PF09809.9 EMD60221.1 - 1.8e-11 43.8 0.1 2.3e-11 43.5 0.1 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L27 Utp14 PF04615.13 EMD60222.1 - 1.6e-204 681.8 78.0 1.6e-204 681.8 78.0 2.2 1 1 1 2 2 2 1 Utp14 protein Jas PF16135.5 EMD60222.1 - 0.13 12.4 0.1 1.1 9.5 0.0 2.5 2 0 0 2 2 2 0 TPL-binding domain in jasmonate signalling Glyco_hydro81C PF17652.1 EMD60223.1 - 1.4e-109 366.5 7.0 1.9e-109 366.1 7.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 81 C-terminal domain Glyco_hydro_81 PF03639.13 EMD60223.1 - 5.6e-97 324.8 0.0 7.9e-97 324.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 81 N-terminal domain Na_Ca_ex PF01699.24 EMD60224.1 - 6.8e-45 152.7 42.0 2.5e-24 86.0 16.2 2.4 3 0 0 3 3 3 2 Sodium/calcium exchanger protein 7tm_3 PF00003.22 EMD60224.1 - 0.00091 19.0 21.2 0.0025 17.6 8.2 3.4 1 1 2 3 3 3 2 7 transmembrane sweet-taste receptor of 3 GCPR DUF202 PF02656.15 EMD60224.1 - 7.4 7.1 15.5 1.7 9.1 0.1 4.9 2 1 2 4 4 4 0 Domain of unknown function (DUF202) Pox_RNA_Pol_19 PF05320.12 EMD60226.1 - 0.11 12.5 0.1 0.18 11.8 0.1 1.3 1 0 0 1 1 1 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit DUF1889 PF08986.10 EMD60227.1 - 0.017 15.5 0.0 0.026 15.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1889) DNA_pol_phi PF04931.13 EMD60227.1 - 7.8 4.5 7.3 9.4 4.2 7.3 1.0 1 0 0 1 1 1 0 DNA polymerase phi DHC_N1 PF08385.12 EMD60230.1 - 0.0016 17.2 1.5 0.0021 16.8 1.5 1.0 1 0 0 1 1 1 1 Dynein heavy chain, N-terminal region 1 KxDL PF10241.9 EMD60230.1 - 0.059 13.7 0.7 0.19 12.0 0.5 1.9 1 1 1 2 2 2 0 Uncharacterized conserved protein DUF3848 PF12959.7 EMD60230.1 - 0.095 12.8 0.8 0.26 11.4 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3848) PS-DH PF14765.6 EMD60231.1 - 2.4e-61 207.6 0.0 4.5e-61 206.7 0.0 1.5 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 EMD60231.1 - 4.8e-60 203.7 0.0 8.2e-60 203.0 0.0 1.3 1 0 0 1 1 1 1 Acyl transferase domain ketoacyl-synt PF00109.26 EMD60231.1 - 2.5e-58 197.7 0.1 5.5e-58 196.5 0.1 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.10 EMD60231.1 - 1.2e-57 194.7 0.4 2.9e-57 193.5 0.4 1.6 1 0 0 1 1 1 1 KR domain Ketoacyl-synt_C PF02801.22 EMD60231.1 - 2.2e-33 114.8 0.1 5.7e-33 113.4 0.1 1.8 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 EMD60231.1 - 2.5e-24 85.9 0.1 7.2e-24 84.4 0.0 1.9 2 0 0 2 2 1 1 Ketoacyl-synthetase C-terminal extension Methyltransf_12 PF08242.12 EMD60231.1 - 4.3e-20 72.3 0.0 1.7e-19 70.4 0.0 2.1 2 0 0 2 2 1 1 Methyltransferase domain ADH_zinc_N_2 PF13602.6 EMD60231.1 - 2.1e-13 51.5 0.0 1.1e-12 49.1 0.0 2.3 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 EMD60231.1 - 3.7e-11 43.1 0.1 1.4e-10 41.3 0.1 2.1 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Methyltransf_25 PF13649.6 EMD60231.1 - 6.5e-11 42.8 0.0 1.8e-10 41.4 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMD60231.1 - 3.3e-10 40.0 0.0 9.2e-10 38.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EMD60231.1 - 8.9e-10 38.7 0.0 2.1e-09 37.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMD60231.1 - 9e-09 35.9 0.0 2.4e-08 34.5 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain adh_short PF00106.25 EMD60231.1 - 2.6e-08 33.6 0.4 2.1e-07 30.6 0.1 2.4 2 0 0 2 2 2 1 short chain dehydrogenase PP-binding PF00550.25 EMD60231.1 - 4.6e-07 30.1 0.4 1.6e-06 28.4 0.4 1.9 1 0 0 1 1 1 1 Phosphopantetheine attachment site ADH_N PF08240.12 EMD60231.1 - 0.00017 21.4 0.2 0.00065 19.6 0.1 2.1 2 0 0 2 2 1 1 Alcohol dehydrogenase GroES-like domain Ubie_methyltran PF01209.18 EMD60231.1 - 0.0011 18.4 0.0 0.0022 17.4 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family CoA_trans PF01144.23 EMD60231.1 - 0.029 13.8 0.4 2.1 7.7 0.0 3.2 3 0 0 3 3 3 0 Coenzyme A transferase Thiolase_N PF00108.23 EMD60231.1 - 0.042 13.2 0.4 0.092 12.1 0.4 1.5 1 0 0 1 1 1 0 Thiolase, N-terminal domain Methyltransf_PK PF05891.12 EMD60231.1 - 0.055 13.0 0.0 0.16 11.5 0.0 1.7 1 0 0 1 1 1 0 AdoMet dependent proline di-methyltransferase Methyltransf_16 PF10294.9 EMD60231.1 - 0.15 11.8 0.1 1 9.1 0.1 2.4 2 1 0 2 2 2 0 Lysine methyltransferase PCMT PF01135.19 EMD60231.1 - 0.19 11.4 0.0 0.58 9.9 0.0 1.7 2 0 0 2 2 2 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MFS_1 PF07690.16 EMD60232.1 - 3.2e-34 118.4 45.8 1.8e-32 112.6 39.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Pyr_redox_2 PF07992.14 EMD60233.1 - 5.6e-11 42.2 0.0 8.1e-08 31.8 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 EMD60233.1 - 2.7e-09 36.0 0.0 8.1e-09 34.4 0.0 1.8 1 1 0 1 1 1 1 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.6 EMD60233.1 - 4e-07 30.2 0.0 8.3e-07 29.1 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 EMD60233.1 - 9e-07 28.4 0.0 0.0056 16.0 0.0 3.4 3 1 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EMD60233.1 - 3.5e-05 23.1 0.0 0.0003 20.1 0.0 2.1 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 EMD60233.1 - 0.0083 16.1 0.0 0.75 9.8 0.0 2.4 2 0 0 2 2 2 1 FAD-NAD(P)-binding GIDA PF01134.22 EMD60233.1 - 0.017 14.2 0.0 0.4 9.7 0.0 2.1 2 0 0 2 2 2 0 Glucose inhibited division protein A DAO PF01266.24 EMD60233.1 - 0.081 12.5 0.0 0.13 11.8 0.0 1.5 1 0 0 1 1 1 0 FAD dependent oxidoreductase DUF910 PF06014.11 EMD60233.1 - 0.15 12.1 0.0 0.3 11.1 0.0 1.4 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF910) p450 PF00067.22 EMD60234.1 - 3.3e-42 144.8 0.0 4e-42 144.5 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Mltc_N PF11873.8 EMD60234.1 - 0.12 12.1 0.0 0.23 11.2 0.0 1.4 1 0 0 1 1 1 0 Membrane-bound lytic murein transglycosylase C, N-terminal domain Thioesterase PF00975.20 EMD60235.1 - 3.3e-11 43.8 0.0 4.9e-11 43.2 0.0 1.2 1 0 0 1 1 1 1 Thioesterase domain Abhydrolase_6 PF12697.7 EMD60235.1 - 0.015 15.9 0.0 0.019 15.6 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family p450 PF00067.22 EMD60236.1 - 5.4e-74 249.6 0.0 6.4e-74 249.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Cellulase PF00150.18 EMD60237.1 - 1.9e-49 168.6 0.0 2.5e-49 168.2 0.0 1.0 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) HicA_toxin PF07927.12 EMD60238.1 - 0.047 13.7 0.0 0.15 12.2 0.0 1.9 1 0 0 1 1 1 0 HicA toxin of bacterial toxin-antitoxin, Utp13 PF08625.11 EMD60238.1 - 0.061 13.2 0.0 3 7.7 0.0 2.7 2 1 0 2 2 2 0 Utp13 specific WD40 associated domain SKG6 PF08693.10 EMD60239.1 - 0.00042 19.7 0.4 0.00076 18.8 0.4 1.4 1 0 0 1 1 1 1 Transmembrane alpha-helix domain AMP-binding PF00501.28 EMD60240.1 - 9.5e-95 317.7 0.0 1.5e-94 317.0 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme ketoacyl-synt PF00109.26 EMD60240.1 - 5.1e-84 281.8 0.1 1.3e-83 280.5 0.1 1.8 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.10 EMD60240.1 - 5.2e-62 209.0 6.1 5.1e-61 205.7 0.8 3.2 4 0 0 4 4 3 1 KR domain Acyl_transf_1 PF00698.21 EMD60240.1 - 9e-55 186.4 2.1 1.7e-54 185.5 2.1 1.4 1 0 0 1 1 1 1 Acyl transferase domain NAD_binding_4 PF07993.12 EMD60240.1 - 4.7e-53 180.0 0.0 1.7e-52 178.1 0.0 2.0 1 1 0 1 1 1 1 Male sterility protein Ketoacyl-synt_C PF02801.22 EMD60240.1 - 6.9e-42 142.2 0.6 1.5e-41 141.1 0.6 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain PP-binding PF00550.25 EMD60240.1 - 8.9e-22 77.2 0.0 3.2e-11 43.4 0.0 2.7 2 0 0 2 2 2 2 Phosphopantetheine attachment site Epimerase PF01370.21 EMD60240.1 - 4e-14 52.7 0.1 1.5e-10 41.0 0.0 2.5 2 1 0 2 2 2 2 NAD dependent epimerase/dehydratase family KAsynt_C_assoc PF16197.5 EMD60240.1 - 8e-14 52.0 0.0 2.6e-13 50.4 0.0 1.9 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension adh_short PF00106.25 EMD60240.1 - 7.8e-13 48.3 0.2 3.9e-10 39.5 0.1 2.6 2 0 0 2 2 2 2 short chain dehydrogenase GDP_Man_Dehyd PF16363.5 EMD60240.1 - 4.8e-07 29.5 0.1 0.0035 16.8 0.0 2.3 2 0 0 2 2 2 2 GDP-mannose 4,6 dehydratase adh_short_C2 PF13561.6 EMD60240.1 - 1.3e-05 24.9 0.6 3.8e-05 23.4 0.1 2.0 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase Thiolase_N PF00108.23 EMD60240.1 - 1.5e-05 24.5 0.1 3.6e-05 23.2 0.1 1.5 1 0 0 1 1 1 1 Thiolase, N-terminal domain AMP-binding_C PF13193.6 EMD60240.1 - 2e-05 25.5 0.0 4.8e-05 24.3 0.0 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Polysacc_synt_2 PF02719.15 EMD60240.1 - 0.00044 19.5 0.0 0.88 8.6 0.0 2.3 2 0 0 2 2 2 2 Polysaccharide biosynthesis protein NmrA PF05368.13 EMD60240.1 - 0.00046 19.8 0.8 0.23 11.0 0.0 2.4 2 0 0 2 2 2 2 NmrA-like family NapD PF03927.13 EMD60240.1 - 0.025 14.6 0.3 0.075 13.1 0.3 1.8 1 0 0 1 1 1 0 NapD protein RmlD_sub_bind PF04321.17 EMD60240.1 - 0.039 13.1 0.4 0.42 9.7 0.0 2.3 2 0 0 2 2 2 0 RmlD substrate binding domain NAD_binding_10 PF13460.6 EMD60240.1 - 0.047 13.6 0.1 0.31 10.9 0.0 2.4 2 0 0 2 2 2 0 NAD(P)H-binding 3Beta_HSD PF01073.19 EMD60240.1 - 0.055 12.5 0.1 1.8 7.5 0.1 2.5 2 1 0 2 2 2 0 3-beta hydroxysteroid dehydrogenase/isomerase family Beta_elim_lyase PF01212.21 EMD60241.1 - 7.4e-60 202.7 0.0 8.5e-60 202.5 0.0 1.0 1 0 0 1 1 1 1 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.20 EMD60241.1 - 0.04 12.5 0.0 0.062 11.8 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 EMD60241.1 - 0.096 12.0 0.0 0.15 11.3 0.0 1.2 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family DIOX_N PF14226.6 EMD60242.1 - 2.5e-17 63.7 0.0 4.4e-17 62.9 0.0 1.4 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EMD60242.1 - 6.2e-15 55.5 0.0 1.2e-14 54.5 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily MFS_1 PF07690.16 EMD60243.1 - 5.3e-17 61.8 47.3 1e-16 60.8 46.6 1.8 1 1 0 1 1 1 1 Major Facilitator Superfamily Zn_clus PF00172.18 EMD60244.1 - 5.3e-05 23.3 8.4 9.9e-05 22.4 8.4 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FAD_binding_3 PF01494.19 EMD60247.1 - 2.1e-18 66.7 0.2 1.3e-10 41.1 0.1 2.5 2 1 0 2 2 2 2 FAD binding domain Pyr_redox_3 PF13738.6 EMD60247.1 - 8e-05 22.0 0.1 0.00014 21.2 0.1 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EMD60247.1 - 0.0001 22.4 0.1 0.00026 21.1 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EMD60247.1 - 0.00021 20.5 0.1 0.00045 19.4 0.0 1.5 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.14 EMD60247.1 - 0.00025 20.4 0.2 0.00051 19.4 0.1 1.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EMD60247.1 - 0.00047 19.3 0.0 0.0007 18.7 0.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein GIDA PF01134.22 EMD60247.1 - 0.018 14.1 0.1 0.031 13.4 0.1 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A DAO PF01266.24 EMD60247.1 - 0.019 14.6 0.3 0.049 13.2 0.1 1.5 1 1 0 1 1 1 0 FAD dependent oxidoreductase HI0933_like PF03486.14 EMD60247.1 - 0.021 13.5 0.1 0.034 12.9 0.1 1.3 1 0 0 1 1 1 0 HI0933-like protein Aldolase_II PF00596.21 EMD60249.1 - 1.7e-32 112.9 0.2 2.4e-32 112.4 0.2 1.2 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain Lipase_3 PF01764.25 EMD60250.1 - 2.5e-28 98.7 0.0 3.7e-28 98.2 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) Lipase3_N PF03893.16 EMD60250.1 - 2.9e-08 33.6 0.2 5.5e-08 32.7 0.2 1.4 1 0 0 1 1 1 1 Lipase 3 N-terminal region Hydrolase_4 PF12146.8 EMD60250.1 - 0.00096 18.5 0.0 0.0019 17.5 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EMD60250.1 - 0.0022 18.6 0.0 0.0029 18.3 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF2974 PF11187.8 EMD60250.1 - 0.033 13.8 0.5 0.16 11.5 0.5 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF2974) Barwin PF00967.17 EMD60250.1 - 0.081 12.8 0.2 0.19 11.6 0.1 1.7 2 0 0 2 2 2 0 Barwin family ArsA_ATPase PF02374.15 EMD60251.1 - 6.1e-117 390.2 0.1 7.2e-117 389.9 0.1 1.0 1 0 0 1 1 1 1 Anion-transporting ATPase AAA_31 PF13614.6 EMD60251.1 - 1.5e-14 54.3 0.1 8.1e-13 48.7 0.0 2.5 2 1 0 2 2 2 1 AAA domain CbiA PF01656.23 EMD60251.1 - 5.8e-13 49.0 0.0 1.3e-12 47.8 0.0 1.8 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain ParA PF10609.9 EMD60251.1 - 1.4e-07 31.3 0.7 7.1e-05 22.4 0.0 2.6 3 0 0 3 3 3 2 NUBPL iron-transfer P-loop NTPase SRP54 PF00448.22 EMD60251.1 - 1.5e-06 28.0 0.2 0.00051 19.7 0.0 2.8 3 0 0 3 3 3 1 SRP54-type protein, GTPase domain Fer4_NifH PF00142.18 EMD60251.1 - 4.6e-06 26.3 0.0 1.1e-05 25.0 0.0 1.7 1 0 0 1 1 1 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family CBP_BcsQ PF06564.12 EMD60251.1 - 1.3e-05 24.8 0.0 6.2e-05 22.6 0.0 2.0 2 0 0 2 2 2 1 Cellulose biosynthesis protein BcsQ AAA_25 PF13481.6 EMD60251.1 - 0.027 14.1 0.4 0.13 11.8 0.4 2.1 1 1 0 1 1 1 0 AAA domain VirC1 PF07015.11 EMD60251.1 - 0.061 12.6 0.0 0.38 10.0 0.0 2.0 2 0 0 2 2 2 0 VirC1 protein Zeta_toxin PF06414.12 EMD60251.1 - 0.061 12.6 0.0 0.12 11.6 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin PhoH PF02562.16 EMD60251.1 - 0.063 12.7 0.0 0.18 11.2 0.0 1.7 2 0 0 2 2 2 0 PhoH-like protein AAA_16 PF13191.6 EMD60251.1 - 0.077 13.4 0.0 0.12 12.8 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain NB-ARC PF00931.22 EMD60251.1 - 0.14 11.3 0.0 0.31 10.2 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain AAA_18 PF13238.6 EMD60251.1 - 0.14 12.7 0.5 0.31 11.6 0.1 2.0 2 1 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 EMD60251.1 - 0.16 11.6 0.0 0.31 10.7 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein T2SSE PF00437.20 EMD60251.1 - 0.18 10.8 0.0 0.41 9.7 0.0 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein DUF2537 PF10801.8 EMD60251.1 - 0.22 11.8 0.0 0.41 10.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2537) SNF2_N PF00176.23 EMD60252.1 - 7.4e-74 248.6 0.1 1.6e-73 247.5 0.0 1.6 2 0 0 2 2 2 1 SNF2 family N-terminal domain SLIDE PF09111.10 EMD60252.1 - 5.5e-41 139.2 3.2 1.4e-40 137.9 0.8 2.9 2 0 0 2 2 2 1 SLIDE HAND PF09110.11 EMD60252.1 - 8.3e-36 123.1 2.4 8.3e-36 123.1 2.4 4.2 5 0 0 5 5 5 1 HAND Helicase_C PF00271.31 EMD60252.1 - 4.6e-18 65.6 0.0 1.5e-17 64.0 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EMD60252.1 - 6.4e-09 36.0 0.0 4.6e-08 33.3 0.0 2.5 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Myb_DNA-binding PF00249.31 EMD60252.1 - 1e-05 25.6 0.2 0.36 11.0 0.1 3.2 2 0 0 2 2 2 2 Myb-like DNA-binding domain HDA2-3 PF11496.8 EMD60252.1 - 0.00011 21.4 2.3 0.00013 21.2 0.0 2.2 2 0 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 SWI2_SNF2 PF18766.1 EMD60252.1 - 0.00016 21.4 0.1 0.00077 19.2 0.0 2.3 3 0 0 3 3 3 1 SWI2/SNF2 ATPase DEAD PF00270.29 EMD60252.1 - 0.00086 19.1 0.0 0.0022 17.8 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase ERCC3_RAD25_C PF16203.5 EMD60252.1 - 0.0012 18.1 0.4 0.0038 16.5 0.4 1.7 1 1 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase AAA_14 PF13173.6 EMD60252.1 - 0.079 13.0 0.0 0.24 11.4 0.0 1.9 1 0 0 1 1 1 0 AAA domain TcfC PF16967.5 EMD60253.1 - 0.081 12.4 0.0 0.14 11.6 0.0 1.3 1 0 0 1 1 1 0 E-set like domain HTH_psq PF05225.16 EMD60255.1 - 1.5e-05 24.6 0.1 1.9e-05 24.3 0.1 1.2 1 0 0 1 1 1 1 helix-turn-helix, Psq domain CENP-B_N PF04218.13 EMD60255.1 - 0.016 14.8 0.0 0.025 14.2 0.0 1.3 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain HTH_10 PF04967.12 EMD60255.1 - 0.078 12.8 0.0 0.11 12.4 0.0 1.2 1 0 0 1 1 1 0 HTH DNA binding domain UCH_1 PF13423.6 EMD60256.1 - 4.5e-102 341.9 0.9 7.2e-102 341.3 0.4 1.6 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase RNase_T PF00929.24 EMD60256.1 - 4.1e-19 69.7 0.0 8.2e-19 68.7 0.0 1.5 1 0 0 1 1 1 1 Exonuclease UCH PF00443.29 EMD60256.1 - 7.7e-06 25.6 0.0 9.7e-05 22.0 0.0 2.5 1 1 1 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase DUF4945 PF16303.5 EMD60256.1 - 0.02 14.8 0.1 0.053 13.4 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4945) ANAPC4_WD40 PF12894.7 EMD60256.1 - 0.059 13.7 0.0 0.97 9.8 0.0 2.6 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain LVIVD PF08309.11 EMD60256.1 - 0.14 11.5 0.0 15 5.0 0.0 2.8 2 0 0 2 2 2 0 LVIVD repeat Ima1_N PF09779.9 EMD60256.1 - 0.6 11.0 3.4 0.25 12.2 0.4 1.9 2 0 0 2 2 2 0 Ima1 N-terminal domain TUDOR PF00567.24 EMD60257.1 - 0.00028 20.9 0.1 0.00086 19.3 0.0 1.7 2 0 0 2 2 2 1 Tudor domain Agenet PF05641.12 EMD60257.1 - 0.0016 18.9 0.1 0.0037 17.7 0.1 1.6 1 0 0 1 1 1 1 Agenet domain DUF3584 PF12128.8 EMD60257.1 - 0.032 11.8 3.9 0.036 11.6 3.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Tudor_2 PF18104.1 EMD60257.1 - 0.11 12.1 0.0 0.23 11.2 0.0 1.5 1 0 0 1 1 1 0 Jumonji domain-containing protein 2A Tudor domain Tudor-knot PF11717.8 EMD60257.1 - 0.14 12.0 0.0 0.28 11.1 0.0 1.5 1 0 0 1 1 1 0 RNA binding activity-knot of a chromodomain PriC PF07445.12 EMD60257.1 - 0.24 11.3 7.6 0.14 12.1 5.8 1.5 2 0 0 2 2 2 0 Primosomal replication protein priC Fez1 PF06818.15 EMD60257.1 - 0.32 11.4 5.9 0.096 13.1 2.5 1.8 2 0 0 2 2 2 0 Fez1 End3 PF12761.7 EMD60257.1 - 0.57 10.3 6.1 0.07 13.3 1.9 1.6 2 0 0 2 2 2 0 Actin cytoskeleton-regulatory complex protein END3 Mo25 PF08569.11 EMD60257.1 - 0.82 9.0 2.3 1.1 8.5 2.3 1.1 1 0 0 1 1 1 0 Mo25-like SlyX PF04102.12 EMD60257.1 - 0.92 10.2 6.8 1.6 9.4 0.1 2.4 1 1 1 2 2 2 0 SlyX Spc7 PF08317.11 EMD60257.1 - 3 6.6 8.3 19 4.0 8.6 1.8 1 1 0 1 1 1 0 Spc7 kinetochore protein DivIC PF04977.15 EMD60257.1 - 6.2 6.7 7.8 18 5.2 4.5 2.2 1 1 1 2 2 2 0 Septum formation initiator PAP1 PF08601.10 EMD60258.1 - 1.4e-131 439.6 19.3 1.4e-131 439.6 19.3 2.5 2 1 1 3 3 3 1 Transcription factor PAP1 bZIP_1 PF00170.21 EMD60258.1 - 4.8e-09 36.2 10.5 1.2e-08 34.9 10.5 1.6 1 0 0 1 1 1 1 bZIP transcription factor Atg14 PF10186.9 EMD60258.1 - 0.025 13.7 0.3 0.039 13.0 0.3 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 SlyX PF04102.12 EMD60258.1 - 0.032 14.9 1.1 0.07 13.8 1.1 1.6 1 0 0 1 1 1 0 SlyX bZIP_Maf PF03131.17 EMD60258.1 - 0.053 14.0 10.4 0.11 13.0 10.4 1.5 1 0 0 1 1 1 0 bZIP Maf transcription factor HAUS-augmin3 PF14932.6 EMD60258.1 - 0.086 12.4 4.1 0.16 11.5 4.1 1.3 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 SHE3 PF17078.5 EMD60258.1 - 0.087 12.5 5.8 0.18 11.5 5.8 1.4 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 DUF16 PF01519.16 EMD60258.1 - 0.16 12.5 1.3 0.33 11.5 1.3 1.4 1 0 0 1 1 1 0 Protein of unknown function DUF16 bZIP_2 PF07716.15 EMD60258.1 - 0.17 12.0 18.5 0.11 12.6 13.1 3.0 2 1 1 3 3 3 0 Basic region leucine zipper Nop53 PF07767.11 EMD60258.1 - 0.68 9.3 15.9 1.1 8.5 15.9 1.2 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) CDC45 PF02724.14 EMD60258.1 - 4.6 5.4 9.0 6.9 4.8 9.0 1.2 1 0 0 1 1 1 0 CDC45-like protein COesterase PF00135.28 EMD60259.1 - 8.5e-57 193.2 0.0 1.3e-56 192.6 0.0 1.2 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EMD60259.1 - 0.017 15.0 0.1 0.47 10.3 0.0 2.6 3 0 0 3 3 3 0 alpha/beta hydrolase fold GMC_oxred_N PF00732.19 EMD60260.1 - 3.1e-59 200.8 0.0 4e-59 200.4 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EMD60260.1 - 1.9e-29 103.0 0.1 4.9e-29 101.7 0.0 1.8 2 0 0 2 2 2 1 GMC oxidoreductase NAD_binding_8 PF13450.6 EMD60260.1 - 8.7e-05 22.7 0.0 0.00023 21.3 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EMD60260.1 - 0.00026 20.7 2.0 0.0021 17.7 2.1 2.1 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EMD60260.1 - 0.00084 18.5 0.2 0.015 14.4 0.0 2.3 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_3 PF13738.6 EMD60260.1 - 0.0043 16.3 0.3 0.78 8.9 0.0 2.8 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EMD60260.1 - 0.0089 15.3 0.0 0.093 11.9 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EMD60260.1 - 0.017 14.2 0.1 0.034 13.2 0.1 1.4 1 0 0 1 1 1 0 Lycopene cyclase protein Thi4 PF01946.17 EMD60260.1 - 0.037 13.3 0.1 0.081 12.2 0.1 1.5 1 0 0 1 1 1 0 Thi4 family TrkA_N PF02254.18 EMD60260.1 - 0.097 12.9 0.1 0.2 11.9 0.1 1.5 1 0 0 1 1 1 0 TrkA-N domain FAD_binding_3 PF01494.19 EMD60260.1 - 0.12 11.5 0.2 0.2 10.9 0.2 1.2 1 0 0 1 1 1 0 FAD binding domain Pyr_redox PF00070.27 EMD60260.1 - 0.13 12.8 1.5 0.15 12.6 0.3 1.7 2 0 0 2 2 1 0 Pyridine nucleotide-disulphide oxidoreductase Trypan_PARP PF05887.11 EMD60261.1 - 0.031 14.2 0.9 0.051 13.6 0.9 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) HET PF06985.11 EMD60262.1 - 4.8e-25 88.6 0.3 1.4e-23 83.8 0.3 2.4 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) DUF2231 PF09990.9 EMD60263.1 - 1.3e-07 32.0 0.2 1.7e-07 31.6 0.2 1.2 1 0 0 1 1 1 1 Predicted membrane protein (DUF2231) GTA_holin_3TM PF11351.8 EMD60263.1 - 0.058 13.9 0.6 0.12 13.0 0.2 1.6 1 1 1 2 2 2 0 Holin of 3TMs, for gene-transfer release HET PF06985.11 EMD60266.1 - 1.6e-10 41.5 5.2 2.9e-07 31.0 0.1 2.3 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) CNV-Replicase_N PF16688.5 EMD60266.1 - 0.13 12.6 0.0 0.21 11.9 0.0 1.3 1 0 0 1 1 1 0 Replicase polyprotein N-term from Coronavirus nsp1 HET PF06985.11 EMD60267.1 - 1.2e-09 38.6 1.6 2.6e-06 27.9 0.0 2.4 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) Glyco_hydro_115 PF15979.5 EMD60268.1 - 1.9e-105 353.1 0.1 7.2e-77 259.1 0.2 2.2 1 1 1 2 2 2 2 Glycosyl hydrolase family 115 GH115_C PF17829.1 EMD60268.1 - 7.2e-44 149.6 0.0 1.1e-43 149.0 0.0 1.3 1 0 0 1 1 1 1 Gylcosyl hydrolase family 115 C-terminal domain Glyco_hydro_67N PF03648.14 EMD60268.1 - 0.091 13.0 0.0 0.29 11.4 0.0 1.8 1 1 0 1 1 1 0 Glycosyl hydrolase family 67 N-terminus Sugar_tr PF00083.24 EMD60269.1 - 3.3e-81 273.4 25.8 3.9e-81 273.2 25.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD60269.1 - 2.7e-15 56.1 42.9 4.8e-14 52.1 40.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 EMD60269.1 - 0.0026 16.7 4.6 0.0026 16.7 4.6 2.5 2 1 0 2 2 2 1 MFS_1 like family PsbX PF06596.11 EMD60269.1 - 0.25 11.4 2.8 4.7 7.3 0.1 3.0 2 0 0 2 2 2 0 Photosystem II reaction centre X protein (PsbX) zf-CCHC PF00098.23 EMD60270.1 - 0.075 13.1 3.1 0.13 12.4 3.1 1.3 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_2 PF13696.6 EMD60270.1 - 0.082 12.7 1.2 0.11 12.4 1.2 1.2 1 0 0 1 1 1 0 Zinc knuckle HemY_N PF07219.13 EMD60270.1 - 0.8 9.9 4.7 0.87 9.8 4.7 1.2 1 0 0 1 1 1 0 HemY protein N-terminus HET PF06985.11 EMD60274.1 - 2.4e-28 99.3 0.0 4.5e-28 98.4 0.0 1.5 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) DUF3039 PF11238.8 EMD60274.1 - 0.078 12.7 0.0 0.17 11.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3039) Aldedh PF00171.22 EMD60276.1 - 1e-67 228.7 0.6 2.7e-31 108.6 0.4 3.0 2 1 1 3 3 3 3 Aldehyde dehydrogenase family TonB_2 PF13103.6 EMD60278.1 - 0.015 15.5 0.1 0.022 15.0 0.1 1.3 1 1 0 1 1 1 0 TonB C terminal Amidohydro_3 PF07969.11 EMD60279.1 - 1e-57 196.7 0.0 1.2e-57 196.4 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_1 PF01979.20 EMD60279.1 - 7.4e-14 51.8 0.6 8.1e-10 38.5 0.0 3.6 4 0 0 4 4 4 2 Amidohydrolase family WD40 PF00400.32 EMD60280.1 - 2.8e-80 262.1 47.3 3.2e-11 43.6 2.5 8.7 8 0 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD60280.1 - 5.5e-30 103.5 13.3 0.015 15.6 0.1 8.5 1 1 7 8 8 8 8 Anaphase-promoting complex subunit 4 WD40 domain NACHT PF05729.12 EMD60280.1 - 8.2e-27 94.1 0.1 1.5e-26 93.3 0.1 1.4 1 0 0 1 1 1 1 NACHT domain Ge1_WD40 PF16529.5 EMD60280.1 - 1.5e-14 53.7 28.9 0.00012 21.2 1.8 6.7 1 1 5 6 6 6 6 WD40 region of Ge1, enhancer of mRNA-decapping protein HET PF06985.11 EMD60280.1 - 1.4e-12 48.2 5.5 1.1e-09 38.9 0.1 3.4 2 1 1 3 3 3 2 Heterokaryon incompatibility protein (HET) Nup160 PF11715.8 EMD60280.1 - 1.6e-12 46.8 21.5 0.65 8.6 0.1 8.2 1 1 7 8 8 8 8 Nucleoporin Nup120/160 CDtoxinA PF03498.14 EMD60280.1 - 7.5e-10 38.6 0.0 0.052 13.1 0.0 4.7 1 1 3 4 4 4 3 Cytolethal distending toxin A/C domain Nbas_N PF15492.6 EMD60280.1 - 0.00018 21.0 20.6 8.4 5.6 0.4 7.7 1 1 7 8 8 8 1 Neuroblastoma-amplified sequence, N terminal AAA_19 PF13245.6 EMD60280.1 - 0.028 14.8 0.0 0.054 13.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain MEDS PF14417.6 EMD60280.1 - 0.034 14.0 0.1 0.091 12.6 0.1 1.7 1 0 0 1 1 1 0 MEDS: MEthanogen/methylotroph, DcmR Sensory domain DUF5114 PF17141.4 EMD60280.1 - 0.04 14.4 4.6 58 4.3 0.1 5.2 3 1 2 5 5 5 0 Domain of unknown function (DUF5114) AAA_22 PF13401.6 EMD60280.1 - 0.059 13.7 0.1 0.19 12.0 0.0 1.9 2 0 0 2 2 2 0 AAA domain Baculo_gp64 PF03273.13 EMD60280.1 - 0.14 10.9 7.0 13 4.4 0.1 3.6 3 1 0 3 3 3 0 Baculovirus gp64 envelope glycoprotein family DUF2262 PF10020.9 EMD60280.1 - 0.16 12.3 0.2 0.81 10.1 0.4 2.0 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2262) Cytochrom_D1 PF02239.16 EMD60280.1 - 0.2 10.2 2.5 10 4.5 0.1 3.1 1 1 1 3 3 3 0 Cytochrome D1 heme domain Glyco_hydro_18 PF00704.28 EMD60281.1 - 2.5e-23 83.3 0.0 5.3e-23 82.2 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 LysM PF01476.20 EMD60283.1 - 9.6e-10 38.4 0.1 9.7e-06 25.6 0.0 3.0 3 0 0 3 3 3 2 LysM domain LysM PF01476.20 EMD60284.1 - 5.6e-27 93.5 5.0 6.2e-06 26.2 0.0 4.5 4 0 0 4 4 4 4 LysM domain ETF_alpha PF00766.19 EMD60284.1 - 0.019 15.0 0.0 11 6.1 0.0 2.8 3 0 0 3 3 3 0 Electron transfer flavoprotein FAD-binding domain Arc_PepC_II PF06847.11 EMD60285.1 - 0.042 14.4 0.6 0.94 10.0 0.0 2.3 1 1 1 2 2 2 0 Archaeal Peptidase A24 C-terminus Type II Glyco_hydro_18 PF00704.28 EMD60286.1 - 4.4e-70 236.9 2.1 7.2e-70 236.2 2.1 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Chitin_bind_1 PF00187.19 EMD60286.1 - 6e-11 42.6 43.6 1.5e-10 41.4 18.9 4.2 4 0 0 4 4 4 2 Chitin recognition protein Peroxidase_2 PF01328.17 EMD60288.1 - 7.1e-45 153.8 0.0 1.1e-44 153.2 0.0 1.3 1 0 0 1 1 1 1 Peroxidase, family 2 GT87 PF09594.10 EMD60289.1 - 0.12 12.1 0.1 0.12 12.1 0.1 2.4 2 1 0 2 2 2 0 Glycosyltransferase family 87 HET PF06985.11 EMD60290.1 - 2.3e-18 67.0 0.1 2.9e-18 66.6 0.1 1.1 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) MIP-T3_C PF17749.1 EMD60290.1 - 0.092 12.7 0.0 0.13 12.3 0.0 1.1 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 C-terminal region TRI12 PF06609.13 EMD60291.1 - 3e-34 118.4 31.6 5e-34 117.7 31.6 1.4 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_1 PF07690.16 EMD60291.1 - 4.6e-19 68.6 51.3 4.6e-19 68.6 51.3 2.6 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EMD60291.1 - 1e-08 34.5 15.1 1e-08 34.5 15.1 2.9 3 0 0 3 3 3 2 Sugar (and other) transporter DUF3522 PF12036.8 EMD60291.1 - 0.049 13.9 0.7 0.049 13.9 0.7 3.4 2 1 2 4 4 4 0 Protein of unknown function (DUF3522) Oxidored_molyb PF00174.19 EMD60292.1 - 2.2e-46 157.6 0.0 5.3e-46 156.4 0.0 1.7 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain Mo-co_dimer PF03404.16 EMD60292.1 - 1.9e-20 73.3 3.2 3.3e-20 72.5 3.2 1.3 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain Glyco_hydro_127 PF07944.12 EMD60292.1 - 0.043 12.3 0.0 0.064 11.7 0.0 1.1 1 0 0 1 1 1 0 Beta-L-arabinofuranosidase, GH127 DAGK_cat PF00781.24 EMD60293.1 - 0.12 12.0 0.0 0.12 12.0 0.0 1.1 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain PAF-AH_p_II PF03403.13 EMD60294.1 - 3.3e-16 58.8 0.0 6.2e-08 31.6 0.0 2.2 1 1 0 2 2 2 2 Platelet-activating factor acetylhydrolase, isoform II Chlorophyllase2 PF12740.7 EMD60294.1 - 4.1e-06 25.9 0.0 8e-06 24.9 0.0 1.4 1 0 0 1 1 1 1 Chlorophyllase enzyme Abhydrolase_6 PF12697.7 EMD60294.1 - 0.0013 19.4 0.0 0.0016 19.1 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Lipase_3 PF01764.25 EMD60294.1 - 0.012 15.4 0.0 0.022 14.6 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) Abhydrolase_5 PF12695.7 EMD60294.1 - 0.014 15.2 0.2 3.3 7.4 0.0 2.2 2 0 0 2 2 2 0 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EMD60294.1 - 0.031 13.5 0.0 0.072 12.3 0.0 1.6 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EMD60294.1 - 0.062 12.9 0.0 0.88 9.2 0.0 2.2 2 0 0 2 2 2 0 alpha/beta hydrolase fold Chlorophyllase PF07224.11 EMD60294.1 - 0.3 10.1 2.1 2.9 6.8 2.0 2.1 1 1 0 1 1 1 0 Chlorophyllase Fungal_trans_2 PF11951.8 EMD60295.1 - 2.1e-14 53.2 10.9 3.5e-14 52.4 10.9 1.3 1 1 0 1 1 1 1 Fungal specific transcription factor domain adh_short PF00106.25 EMD60296.1 - 5e-26 91.4 0.0 4.3e-24 85.0 0.0 2.1 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD60296.1 - 1.6e-12 47.5 0.0 3.6e-11 43.1 0.0 2.1 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD60296.1 - 1.5e-08 34.8 0.0 2.4e-08 34.1 0.0 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EMD60296.1 - 0.00011 21.8 0.0 0.00014 21.4 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Sacchrp_dh_NADP PF03435.18 EMD60296.1 - 0.0025 18.0 0.0 0.004 17.4 0.0 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Polysacc_synt_2 PF02719.15 EMD60296.1 - 0.004 16.3 0.0 0.0064 15.7 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.6 EMD60296.1 - 0.1 12.5 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 NAD(P)H-binding AA_permease_2 PF13520.6 EMD60297.1 - 5.2e-53 180.4 53.9 6.3e-53 180.1 53.9 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EMD60297.1 - 1.3e-22 80.1 46.1 1.7e-22 79.7 46.1 1.1 1 0 0 1 1 1 1 Amino acid permease DUF1356 PF07092.12 EMD60297.1 - 1 8.6 3.7 2 7.6 3.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1356) Orai-1 PF07856.12 EMD60297.1 - 9 5.9 10.7 0.77 9.4 3.1 2.5 2 0 0 2 2 2 0 Mediator of CRAC channel activity SIR2 PF02146.17 EMD60298.1 - 1.4e-55 188.0 0.0 2.1e-55 187.4 0.0 1.3 1 0 0 1 1 1 1 Sir2 family Cofilin_ADF PF00241.20 EMD60299.1 - 1.3e-22 79.9 0.4 1.5e-22 79.7 0.4 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Homeobox_KN PF05920.11 EMD60301.1 - 7.7e-13 48.1 1.9 2e-12 46.8 1.9 1.8 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 EMD60301.1 - 9.6e-07 28.6 0.4 3.4e-06 26.8 0.2 2.1 2 0 0 2 2 2 1 Homeodomain HTH_Tnp_Tc5 PF03221.16 EMD60301.1 - 5.6e-05 23.1 0.2 0.33 11.0 0.0 4.2 4 1 0 4 4 4 2 Tc5 transposase DNA-binding domain zf-C2H2_4 PF13894.6 EMD60301.1 - 0.00048 20.7 1.7 0.00048 20.7 1.7 4.9 4 1 0 4 4 4 1 C2H2-type zinc finger zf-C2H2 PF00096.26 EMD60301.1 - 0.0023 18.3 1.8 0.0023 18.3 1.8 4.5 4 0 0 4 4 4 2 Zinc finger, C2H2 type Sugar_tr PF00083.24 EMD60302.1 - 5.7e-134 447.4 23.0 6.6e-134 447.2 23.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD60302.1 - 2.5e-22 79.3 25.5 2.5e-22 79.3 25.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Per1 PF04080.13 EMD60302.1 - 0.42 10.3 6.8 0.18 11.6 3.8 1.8 1 1 0 1 1 1 0 Per1-like family DUF2237 PF09996.9 EMD60303.1 - 3e-24 85.2 0.0 4.1e-24 84.8 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2237) PUL PF08324.11 EMD60304.1 - 4.4e-67 226.2 0.6 6.3e-67 225.7 0.6 1.2 1 0 0 1 1 1 1 PUL domain PFU PF09070.11 EMD60304.1 - 4.2e-45 152.6 0.5 7.4e-45 151.8 0.5 1.4 1 0 0 1 1 1 1 PFU (PLAA family ubiquitin binding) WD40 PF00400.32 EMD60304.1 - 1.6e-30 104.7 8.5 4.8e-06 27.2 0.0 7.7 7 0 0 7 7 7 6 WD domain, G-beta repeat WD40_like PF17005.5 EMD60304.1 - 0.0058 16.0 0.0 0.015 14.6 0.0 1.7 1 1 0 1 1 1 1 WD40-like domain BBS2_Mid PF14783.6 EMD60304.1 - 0.018 15.1 0.1 9.7 6.3 0.0 4.1 2 1 1 4 4 4 0 Ciliary BBSome complex subunit 2, middle region BTB PF00651.31 EMD60305.1 - 8.6e-14 51.7 0.1 7e-13 48.8 0.0 2.1 2 0 0 2 2 2 1 BTB/POZ domain T3SS_HrpK1 PF16937.5 EMD60305.1 - 0.11 12.1 0.0 0.19 11.3 0.0 1.3 1 0 0 1 1 1 0 Type III secretion system translocator protein, HrpF DLEU7 PF15760.5 EMD60306.1 - 0.093 12.2 0.1 0.097 12.2 0.1 1.0 1 0 0 1 1 1 0 Leukemia-associated protein 7 Sugar_tr PF00083.24 EMD60308.1 - 8.3e-80 268.8 19.8 1e-79 268.6 19.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD60308.1 - 4.1e-25 88.4 19.3 4.1e-25 88.4 19.3 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily MFS_2 PF13347.6 EMD60308.1 - 0.00037 19.2 1.8 0.00037 19.2 1.8 2.7 3 1 0 3 3 3 2 MFS/sugar transport protein p450 PF00067.22 EMD60309.1 - 1.3e-84 284.6 0.0 1.6e-84 284.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 PI-PLC-C1 PF16670.5 EMD60310.1 - 0.26 10.3 0.0 0.67 9.0 0.0 1.7 1 1 1 2 2 2 0 Phosphoinositide phospholipase C, Ca2+-dependent AAA_12 PF13087.6 EMD60312.1 - 5.6e-40 137.1 0.0 9.2e-40 136.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 EMD60312.1 - 9.8e-26 91.1 0.8 5.7e-25 88.6 0.2 2.3 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EMD60312.1 - 1.9e-10 40.8 0.0 1.1e-07 31.8 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.6 EMD60312.1 - 2.3e-08 34.5 0.1 5e-06 26.9 0.0 2.4 2 0 0 2 2 2 1 AAA domain Viral_helicase1 PF01443.18 EMD60312.1 - 7.7e-06 25.8 0.0 0.0089 15.8 0.0 3.2 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase ResIII PF04851.15 EMD60312.1 - 0.0003 20.8 0.1 0.00057 19.9 0.1 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit PhoH PF02562.16 EMD60312.1 - 0.00097 18.6 0.0 0.002 17.6 0.0 1.4 1 0 0 1 1 1 1 PhoH-like protein DUF2075 PF09848.9 EMD60312.1 - 0.0043 16.3 0.0 0.056 12.7 0.0 2.1 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA_16 PF13191.6 EMD60312.1 - 0.014 15.8 0.1 0.039 14.3 0.1 1.7 1 0 0 1 1 1 0 AAA ATPase domain RuvB_N PF05496.12 EMD60312.1 - 0.032 14.0 0.0 0.12 12.2 0.0 1.9 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain DEAD PF00270.29 EMD60312.1 - 0.06 13.1 0.1 0.1 12.3 0.1 1.5 1 1 0 1 1 1 0 DEAD/DEAH box helicase AAA_25 PF13481.6 EMD60312.1 - 0.12 12.0 0.0 0.24 10.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain CDH-cyt PF16010.5 EMD60316.1 - 4.8e-20 72.0 0.0 8.5e-20 71.2 0.0 1.3 1 0 0 1 1 1 1 Cytochrome domain of cellobiose dehydrogenase DUF4079 PF13301.6 EMD60316.1 - 0.0027 17.9 4.3 0.0027 17.9 4.3 2.6 2 1 0 3 3 3 1 Protein of unknown function (DUF4079) DOMON PF03351.17 EMD60316.1 - 0.0054 17.0 0.1 0.01 16.0 0.1 1.6 1 1 0 1 1 1 1 DOMON domain Peptidase_U4 PF03419.13 EMD60316.1 - 5.4 6.2 11.9 15 4.7 11.9 1.7 1 1 0 1 1 1 0 Sporulation factor SpoIIGA Presenilin PF01080.17 EMD60316.1 - 5.6 5.6 9.5 4.1 6.1 7.8 1.6 1 1 1 2 2 2 0 Presenilin TraL PF07178.11 EMD60317.1 - 0.094 13.2 0.8 0.18 12.3 0.8 1.4 1 0 0 1 1 1 0 TraL protein Isochorismatase PF00857.20 EMD60318.1 - 3.4e-41 141.3 0.0 4.5e-41 140.9 0.0 1.1 1 0 0 1 1 1 1 Isochorismatase family AA_permease_2 PF13520.6 EMD60319.1 - 5.3e-60 203.4 47.8 6.6e-60 203.1 47.8 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EMD60319.1 - 3.5e-21 75.4 42.2 4.5e-21 75.0 42.2 1.1 1 0 0 1 1 1 1 Amino acid permease Phage_holin_3_6 PF07332.11 EMD60319.1 - 0.18 11.9 0.1 0.18 11.9 0.1 4.0 3 1 2 5 5 5 0 Putative Actinobacterial Holin-X, holin superfamily III MAD PF05557.13 EMD60320.1 - 0.0032 15.9 24.2 0.0043 15.5 24.2 1.1 1 0 0 1 1 1 1 Mitotic checkpoint protein Fib_alpha PF08702.10 EMD60320.1 - 0.036 14.2 15.6 0.13 12.5 5.9 2.5 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family OmpH PF03938.14 EMD60320.1 - 0.058 13.7 21.2 0.93 9.8 9.7 2.2 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Sulphotransf PF09037.10 EMD60320.1 - 0.061 12.9 0.9 0.15 11.6 0.9 1.8 1 0 0 1 1 1 0 Stf0 sulphotransferase FPP PF05911.11 EMD60320.1 - 0.082 11.1 21.8 0.18 10.0 21.8 1.5 1 1 0 1 1 1 0 Filament-like plant protein, long coiled-coil AAA_13 PF13166.6 EMD60320.1 - 0.22 10.1 21.3 0.51 8.9 21.1 1.6 1 1 0 1 1 1 0 AAA domain Spc7 PF08317.11 EMD60320.1 - 0.33 9.8 29.8 0.19 10.6 12.9 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein ATG16 PF08614.11 EMD60320.1 - 0.85 9.8 26.9 2.8 8.1 9.5 2.3 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Lebercilin PF15619.6 EMD60320.1 - 0.95 9.1 29.9 1.3 8.6 11.9 2.9 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease TssO PF17561.2 EMD60320.1 - 1.3 9.1 3.9 0.69 10.0 0.5 2.0 1 1 0 2 2 2 0 Type VI secretion system, TssO HemX PF04375.14 EMD60320.1 - 1.8 7.8 18.1 0.94 8.7 8.0 2.2 1 1 0 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase HrpB7 PF09486.10 EMD60320.1 - 2 8.8 28.7 0.16 12.4 3.4 3.3 1 1 2 3 3 3 0 Bacterial type III secretion protein (HrpB7) DUF1664 PF07889.12 EMD60320.1 - 2.4 8.2 17.6 4.1 7.5 2.7 3.7 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) TPR_MLP1_2 PF07926.12 EMD60320.1 - 7.9 6.6 28.6 5.5 7.1 18.5 2.8 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein IMS PF00817.20 EMD60324.1 - 3.3e-40 137.5 0.0 4.9e-40 137.0 0.0 1.3 1 0 0 1 1 1 1 impB/mucB/samB family zf_UBZ PF18439.1 EMD60324.1 - 4.9e-15 54.8 0.2 9.7e-15 53.9 0.2 1.5 1 0 0 1 1 1 1 Ubiquitin-Binding Zinc Finger IMS_C PF11799.8 EMD60324.1 - 1.2e-11 45.4 0.0 5.5e-11 43.2 0.0 2.1 3 0 0 3 3 3 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.8 EMD60324.1 - 0.0081 16.4 0.0 0.019 15.3 0.0 1.7 1 0 0 1 1 1 1 IMS family HHH motif Caleosin PF05042.13 EMD60325.1 - 5.2e-76 254.3 0.0 6.5e-76 254.0 0.0 1.1 1 0 0 1 1 1 1 Caleosin related protein EF-hand_6 PF13405.6 EMD60325.1 - 0.066 13.2 1.6 3.4 7.8 0.1 2.7 2 0 0 2 2 2 0 EF-hand domain CFEM PF05730.11 EMD60326.1 - 2.6e-13 49.8 10.9 5.7e-13 48.7 10.9 1.6 1 0 0 1 1 1 1 CFEM domain FAD_binding_4 PF01565.23 EMD60327.1 - 5.7e-21 74.7 2.0 1.1e-20 73.8 2.0 1.5 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EMD60327.1 - 2.8e-13 49.7 1.9 7e-13 48.5 0.6 2.2 2 0 0 2 2 2 1 Berberine and berberine like Cytokin-bind PF09265.10 EMD60327.1 - 0.1 11.9 0.1 0.19 11.1 0.1 1.4 1 0 0 1 1 1 0 Cytokinin dehydrogenase 1, FAD and cytokinin binding Fungal_trans PF04082.18 EMD60329.1 - 2.4e-14 53.0 0.1 3.9e-14 52.3 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD60329.1 - 6.6e-07 29.3 15.4 1.4e-06 28.3 15.4 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain NmrA PF05368.13 EMD60330.1 - 5.2e-07 29.4 0.0 8e-07 28.8 0.0 1.4 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EMD60330.1 - 3.4e-06 27.1 0.0 6.1e-06 26.2 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding 2-Hacid_dh_C PF02826.19 EMD60331.1 - 2.6e-59 199.6 0.0 3.5e-59 199.1 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EMD60331.1 - 1.6e-20 73.1 0.0 1.8e-20 72.9 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain IlvN PF07991.12 EMD60331.1 - 0.0016 18.0 0.1 0.003 17.2 0.1 1.4 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain NAD_binding_2 PF03446.15 EMD60331.1 - 0.0045 17.2 0.1 0.011 16.0 0.0 1.6 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase Sugar_tr PF00083.24 EMD60332.1 - 3.7e-123 411.7 23.2 4.2e-123 411.5 23.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD60332.1 - 1.8e-23 83.0 31.9 2.5e-23 82.6 27.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily HPP PF04982.13 EMD60332.1 - 0.74 10.0 4.9 5.9 7.1 0.3 3.0 2 1 0 2 2 2 0 HPP family Fungal_trans PF04082.18 EMD60335.1 - 4e-22 78.5 0.4 7.3e-22 77.7 0.4 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD60335.1 - 2.9e-06 27.3 9.4 2.9e-06 27.3 9.4 1.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MaoC_dehydrat_N PF13452.6 EMD60336.1 - 0.008 16.3 0.0 0.07 13.3 0.0 2.1 2 0 0 2 2 2 1 N-terminal half of MaoC dehydratase Zip PF02535.22 EMD60337.1 - 4.9e-46 157.5 18.8 4.9e-46 157.5 18.8 2.0 2 0 0 2 2 2 1 ZIP Zinc transporter HRXXH PF13933.6 EMD60338.1 - 1.3e-103 345.8 0.0 1.8e-103 345.4 0.0 1.2 1 0 0 1 1 1 1 Putative peptidase family Aspzincin_M35 PF14521.6 EMD60338.1 - 0.0052 17.3 0.0 0.012 16.2 0.0 1.6 1 0 0 1 1 1 1 Lysine-specific metallo-endopeptidase Sporozoite_P67 PF05642.11 EMD60338.1 - 0.066 11.3 0.1 0.079 11.0 0.1 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF2284 PF10050.9 EMD60338.1 - 0.22 11.2 0.5 0.51 10.1 0.5 1.6 1 0 0 1 1 1 0 Predicted metal-binding protein (DUF2284) GST_C PF00043.25 EMD60339.1 - 3.2e-12 46.5 0.1 5.1e-12 45.8 0.1 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EMD60339.1 - 1.9e-08 34.6 0.0 3.1e-08 33.9 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EMD60339.1 - 1.8e-07 31.3 0.0 2.6e-07 30.8 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EMD60339.1 - 1.3e-06 28.7 0.0 2.6e-06 27.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EMD60339.1 - 7.2e-06 25.9 0.0 1.5e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 EMD60339.1 - 0.026 14.8 0.0 0.045 14.1 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain GST_N_4 PF17172.4 EMD60339.1 - 0.071 13.9 0.0 0.15 12.8 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase N-terminal domain DUF3949 PF13133.6 EMD60339.1 - 0.089 13.3 0.0 0.66 10.5 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3949) GST_C_6 PF17171.4 EMD60339.1 - 0.15 11.8 0.1 0.51 10.2 0.0 2.0 2 1 0 2 2 2 0 Glutathione S-transferase, C-terminal domain AhpC-TSA_2 PF13911.6 EMD60340.1 - 3.1e-10 40.2 0.0 4.7e-10 39.6 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme AhpC-TSA PF00578.21 EMD60340.1 - 0.00028 20.8 0.0 0.00051 20.0 0.0 1.4 1 0 0 1 1 1 1 AhpC/TSA family Y_phosphatase3 PF13350.6 EMD60341.1 - 3.5e-51 174.4 0.0 5.3e-51 173.8 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase2 PF03162.13 EMD60341.1 - 0.017 14.7 0.0 0.028 14.0 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family TRAM_LAG1_CLN8 PF03798.16 EMD60342.1 - 1.5e-46 158.6 21.5 1.5e-46 158.6 21.5 2.1 2 0 0 2 2 2 1 TLC domain TRAM1 PF08390.11 EMD60342.1 - 7e-19 67.3 0.0 7e-19 67.3 0.0 2.3 2 0 0 2 2 2 1 TRAM1-like protein Bax1-I PF01027.20 EMD60343.1 - 1.5e-52 178.5 29.9 1.7e-52 178.3 29.9 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 Spore_YhaL PF14147.6 EMD60343.1 - 1.5 8.6 3.8 0.59 9.9 0.2 2.2 2 0 0 2 2 2 0 Sporulation protein YhaL 7TMR-DISM_7TM PF07695.11 EMD60343.1 - 3.2 7.6 29.7 3.6 7.4 15.1 2.1 1 1 1 2 2 2 0 7TM diverse intracellular signalling DUF4133 PF13571.6 EMD60344.1 - 0.062 13.6 0.2 0.28 11.6 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4133) ABC2_membrane_5 PF13346.6 EMD60344.1 - 0.46 10.0 5.0 0.67 9.5 5.0 1.3 1 0 0 1 1 1 0 ABC-2 family transporter protein Epiglycanin_TR PF05647.11 EMD60344.1 - 1.2 9.1 12.8 0.62 10.0 10.4 1.7 1 1 0 1 1 1 0 Tandem-repeating region of mucin, epiglycanin-like Cys_knot PF00007.22 EMD60345.1 - 0.054 13.8 1.1 0.054 13.8 1.1 2.1 2 0 0 2 2 2 0 Cystine-knot domain Septin PF00735.18 EMD60347.1 - 5e-109 363.9 0.0 1e-108 362.9 0.0 1.5 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.23 EMD60347.1 - 3.6e-06 27.0 0.0 8.7e-06 25.8 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 EMD60347.1 - 0.00016 21.8 3.8 0.19 11.7 0.0 3.1 2 1 1 3 3 3 2 Dynamin family RsgA_GTPase PF03193.16 EMD60347.1 - 0.0055 16.6 0.6 0.0055 16.6 0.6 2.7 3 1 0 3 3 3 1 RsgA GTPase IIGP PF05049.13 EMD60347.1 - 0.013 14.6 0.1 0.023 13.8 0.1 1.4 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) GTP_EFTU PF00009.27 EMD60347.1 - 0.015 14.8 0.5 0.44 10.1 0.1 2.4 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain AIG1 PF04548.16 EMD60347.1 - 0.076 12.3 0.0 0.076 12.3 0.0 1.7 2 0 0 2 2 2 0 AIG1 family Roc PF08477.13 EMD60347.1 - 0.15 12.3 0.0 0.35 11.1 0.0 1.6 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_22 PF13401.6 EMD60347.1 - 0.15 12.3 1.9 0.24 11.7 0.2 2.3 2 1 0 2 2 2 0 AAA domain AAA_23 PF13476.6 EMD60347.1 - 0.55 10.7 6.3 9.8 6.6 4.1 2.2 2 0 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.18 EMD60347.1 - 1.5 8.2 4.1 0.25 10.6 0.2 1.7 2 0 0 2 2 2 0 FtsK/SpoIIIE family ANAPC4_WD40 PF12894.7 EMD60348.1 - 3.8e-06 27.1 0.0 3.8e-05 23.9 0.0 2.3 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EMD60348.1 - 1.2e-05 26.0 0.4 0.023 15.6 0.0 3.1 3 0 0 3 3 3 2 WD domain, G-beta repeat PD40 PF07676.12 EMD60348.1 - 0.007 16.3 0.1 0.018 15.0 0.1 1.6 1 0 0 1 1 1 1 WD40-like Beta Propeller Repeat CPSF_A PF03178.15 EMD60348.1 - 0.031 13.6 0.0 2.1 7.6 0.0 2.1 2 0 0 2 2 2 0 CPSF A subunit region Nbas_N PF15492.6 EMD60348.1 - 0.11 11.8 0.0 0.35 10.1 0.0 1.7 1 1 0 1 1 1 0 Neuroblastoma-amplified sequence, N terminal Carboxyl_trans PF01039.22 EMD60349.1 - 6.7e-138 460.4 0.3 9.3e-138 459.9 0.3 1.2 1 0 0 1 1 1 1 Carboxyl transferase domain Glyco_hydro_76 PF03663.14 EMD60349.1 - 1.7e-127 425.9 7.9 2.2e-127 425.6 7.9 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 EMD60349.1 - 0.45 9.5 8.1 0.49 9.4 0.2 2.9 3 0 0 3 3 3 0 Glycosyl Hydrolase Family 88 YjeF_N PF03853.15 EMD60350.1 - 3e-33 115.1 0.0 3.6e-33 114.8 0.0 1.1 1 0 0 1 1 1 1 YjeF-related protein N-terminus SL4P PF17618.2 EMD60350.1 - 0.009 16.0 0.1 0.015 15.3 0.1 1.3 1 0 0 1 1 1 1 Uncharacterized Strongylid L4 protein HeLo PF14479.6 EMD60352.1 - 2e-16 60.4 0.0 2.6e-16 60.1 0.0 1.1 1 0 0 1 1 1 1 Prion-inhibition and propagation NAAA-beta PF15508.6 EMD60352.1 - 0.11 12.8 0.1 0.26 11.6 0.1 1.6 1 0 0 1 1 1 0 beta subunit of N-acylethanolamine-hydrolyzing acid amidase Pkinase PF00069.25 EMD60353.1 - 1.1e-11 44.7 0.0 2.2e-11 43.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD60353.1 - 6.6e-10 38.7 0.0 1.2e-09 37.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Ank_2 PF12796.7 EMD60353.1 - 3.4e-06 27.6 0.0 0.00032 21.2 0.0 3.4 4 1 0 4 4 4 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMD60353.1 - 0.00011 22.7 0.0 0.76 10.4 0.0 5.0 4 1 1 5 5 5 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMD60353.1 - 0.00044 20.5 0.1 1.1 10.1 0.0 5.0 5 0 0 5 5 5 1 Ankyrin repeat Ank PF00023.30 EMD60353.1 - 0.052 14.0 0.0 17 6.1 0.0 4.3 4 0 0 4 4 4 0 Ankyrin repeat Ank_5 PF13857.6 EMD60353.1 - 0.16 12.4 0.0 1.5 9.3 0.0 2.7 3 0 0 3 3 3 0 Ankyrin repeats (many copies) Ribosomal_S16 PF00886.19 EMD60354.1 - 7.6e-25 86.8 0.2 1.2e-24 86.2 0.2 1.3 1 0 0 1 1 1 1 Ribosomal protein S16 Aa_trans PF01490.18 EMD60355.1 - 2.7e-92 309.6 18.6 4.2e-92 309.0 18.6 1.2 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Dynactin_p22 PF07426.11 EMD60356.1 - 2.3e-11 43.8 1.9 3.2e-11 43.4 1.9 1.1 1 0 0 1 1 1 1 Dynactin subunit p22 TMCO5 PF14992.6 EMD60356.1 - 0.046 13.3 0.3 0.076 12.6 0.3 1.4 1 0 0 1 1 1 0 TMCO5 family UIM PF02809.20 EMD60356.1 - 1.8 8.6 7.2 0.91 9.6 1.5 3.5 2 0 0 2 2 2 0 Ubiquitin interaction motif DUF4611 PF15387.6 EMD60356.1 - 4.1 7.7 13.8 0.73 10.1 3.4 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4611) SH3_1 PF00018.28 EMD60357.1 - 1.2e-09 37.6 0.1 2.1e-09 36.8 0.1 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EMD60357.1 - 1.7e-07 31.0 0.0 3.3e-07 30.0 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EMD60357.1 - 1.3e-06 28.0 0.0 2.3e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain DUF5134 PF17197.4 EMD60357.1 - 0.0026 17.7 1.0 0.0043 17.0 0.7 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF5134) DUF2069 PF09842.9 EMD60357.1 - 0.29 11.4 5.4 0.41 10.9 2.1 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2069) OsmC PF02566.19 EMD60358.1 - 3.5e-13 49.9 0.0 6.4e-13 49.0 0.0 1.3 1 0 0 1 1 1 1 OsmC-like protein Homeobox_KN PF05920.11 EMD60360.1 - 1.6e-18 66.3 0.5 3.8e-18 65.1 0.5 1.7 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 EMD60360.1 - 4.9e-09 35.9 0.8 1.1e-08 34.8 0.8 1.6 1 0 0 1 1 1 1 Homeodomain Homez PF11569.8 EMD60360.1 - 0.0013 18.2 1.7 0.031 13.7 0.0 2.9 3 0 0 3 3 3 1 Homeodomain leucine-zipper encoding, Homez DHHC PF01529.20 EMD60362.1 - 1.2e-28 99.8 5.6 8e-28 97.2 1.0 2.2 2 0 0 2 2 2 2 DHHC palmitoyltransferase DUF1772 PF08592.11 EMD60362.1 - 0.051 13.9 0.2 0.34 11.2 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1772) PRIMA1 PF16101.5 EMD60362.1 - 2 8.5 5.5 1 9.4 1.6 2.2 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 Arrestin_N PF00339.29 EMD60367.1 - 0.011 15.7 0.7 0.054 13.5 0.3 2.2 2 1 0 2 2 2 0 Arrestin (or S-antigen), N-terminal domain Annexin PF00191.20 EMD60368.1 - 4.8e-59 196.3 5.4 6.4e-17 61.4 0.1 4.2 4 0 0 4 4 4 4 Annexin DUF3574 PF12098.8 EMD60368.1 - 0.004 16.9 0.6 1.7 8.5 0.0 3.8 4 0 0 4 4 4 1 Protein of unknown function (DUF3574) TFIIA PF03153.13 EMD60370.1 - 0.9 9.5 10.6 1.1 9.2 10.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Gly_transf_sug PF04488.15 EMD60371.1 - 3e-14 53.4 0.0 9.2e-14 51.9 0.0 1.8 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif DUF2540 PF10802.8 EMD60371.1 - 0.16 12.1 0.0 0.34 11.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2540) DDE_Tnp_Tn3 PF01526.17 EMD60373.1 - 0.026 13.3 0.1 0.04 12.7 0.1 1.2 1 0 0 1 1 1 0 Tn3 transposase DDE domain Glyco_transf_54 PF04666.13 EMD60374.1 - 1.2e-10 40.7 0.0 3.4e-07 29.4 0.0 3.1 3 0 0 3 3 3 3 N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region TRAP-gamma PF07074.12 EMD60374.1 - 0.033 13.7 0.3 0.066 12.8 0.3 1.4 1 0 0 1 1 1 0 Translocon-associated protein, gamma subunit (TRAP-gamma) Glycos_transf_2 PF00535.26 EMD60374.1 - 0.056 13.3 0.0 4.2 7.1 0.0 2.4 2 0 0 2 2 2 0 Glycosyl transferase family 2 Ntox8 PF15545.6 EMD60374.1 - 0.17 12.0 0.1 0.75 9.9 0.0 2.0 2 0 0 2 2 2 0 Bacterial toxin 8 Integrase_H2C2 PF17921.1 EMD60376.1 - 0.00011 22.3 0.0 0.00012 22.1 0.0 1.1 1 0 0 1 1 1 1 Integrase zinc binding domain DUF3716 PF12511.8 EMD60379.1 - 3.9e-08 33.2 3.1 6.4e-08 32.5 3.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3716) HCO3_cotransp PF00955.21 EMD60380.1 - 3.2e-72 244.0 13.4 1.4e-40 139.7 7.7 2.1 1 1 1 2 2 2 2 HCO3- transporter family DEAD PF00270.29 EMD60381.1 - 5.1e-40 137.1 0.0 1.3e-39 135.7 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EMD60381.1 - 3.5e-29 101.4 0.0 1.1e-28 99.7 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SET PF00856.28 EMD60381.1 - 7.1e-10 39.5 0.0 2.5e-09 37.7 0.0 1.9 2 0 0 2 2 2 1 SET domain ResIII PF04851.15 EMD60381.1 - 0.0008 19.4 0.0 0.0016 18.5 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Pyridox_ox_2 PF12900.7 EMD60382.1 - 1.2e-37 129.1 0.0 1.7e-37 128.6 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Vac_ImportDeg PF09783.9 EMD60383.1 - 3.4e-32 111.5 0.2 3.5e-20 72.4 0.0 2.3 2 0 0 2 2 2 2 Vacuolar import and degradation protein DUF2524 PF10732.9 EMD60383.1 - 3.5 8.0 6.1 59 4.1 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2524) LST1 PF05083.13 EMD60385.1 - 0.32 11.3 0.1 0.32 11.3 0.1 1.7 2 0 0 2 2 2 0 LST-1 protein SelP_N PF04592.14 EMD60385.1 - 2 7.8 9.1 2.8 7.3 9.1 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region p450 PF00067.22 EMD60387.1 - 1e-65 222.3 0.0 1.3e-65 221.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 EF-hand_13 PF17958.1 EMD60387.1 - 0.045 13.5 0.0 0.18 11.6 0.0 1.9 1 1 0 1 1 1 0 EF-hand domain SMP PF04927.12 EMD60388.1 - 1.1e-06 29.0 6.0 0.56 10.7 0.8 4.2 3 1 1 4 4 4 4 Seed maturation protein Arrestin_C PF02752.22 EMD60389.1 - 3.4e-11 43.7 0.0 2e-10 41.2 0.1 2.1 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 EMD60389.1 - 0.003 17.6 0.1 4 7.5 0.0 2.9 2 1 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain bZIP_1 PF00170.21 EMD60391.1 - 5.8e-06 26.3 7.2 5.8e-06 26.3 7.2 2.2 3 0 0 3 3 3 1 bZIP transcription factor bZIP_2 PF07716.15 EMD60391.1 - 0.0036 17.4 7.1 0.013 15.5 7.1 2.0 1 0 0 1 1 1 1 Basic region leucine zipper Vir_act_alpha_C PF10400.9 EMD60391.1 - 0.31 11.7 4.1 0.42 11.3 2.1 2.1 2 0 0 2 2 2 0 Virulence activator alpha C-term Stm1_N PF09598.10 EMD60392.1 - 1.2e-14 54.9 2.0 1.2e-14 54.9 2.0 4.6 4 2 1 5 5 5 1 Stm1 HABP4_PAI-RBP1 PF04774.15 EMD60392.1 - 3.4e-07 31.1 6.7 3.4e-07 31.1 6.7 2.4 2 0 0 2 2 2 1 Hyaluronan / mRNA binding family Keratin_2_head PF16208.5 EMD60392.1 - 4.5 7.4 30.8 6.5 6.9 7.6 2.2 2 0 0 2 2 2 0 Keratin type II head IBR PF01485.21 EMD60393.1 - 9.2e-12 45.0 43.1 2.1e-07 31.0 2.4 4.7 5 0 0 5 5 5 3 IBR domain, a half RING-finger domain Glyco_hydro_3_C PF01915.22 EMD60394.1 - 1.9e-51 174.9 0.0 3.6e-51 174.0 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 EMD60394.1 - 7.6e-31 107.7 0.0 1.8e-30 106.4 0.0 1.6 2 0 0 2 2 2 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 EMD60394.1 - 1.3e-15 57.2 0.0 2.9e-15 56.1 0.0 1.6 1 0 0 1 1 1 1 Fibronectin type III-like domain Forkhead PF00250.18 EMD60396.1 - 6.7e-33 112.8 0.2 1.2e-32 112.0 0.2 1.4 1 0 0 1 1 1 1 Forkhead domain FHA PF00498.26 EMD60396.1 - 8.1e-09 35.7 0.1 1.8e-08 34.6 0.1 1.7 1 0 0 1 1 1 1 FHA domain Ndufs5 PF10200.9 EMD60397.1 - 0.0095 16.2 0.0 0.013 15.8 0.0 1.2 1 0 0 1 1 1 1 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa DUF3128 PF11326.8 EMD60397.1 - 0.016 15.6 0.8 0.058 13.8 0.9 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3128) UPF0203 PF05254.12 EMD60397.1 - 0.077 13.2 0.9 0.17 12.2 0.9 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0203) COX17 PF05051.13 EMD60397.1 - 0.092 13.1 0.3 0.16 12.4 0.3 1.4 1 0 0 1 1 1 0 Cytochrome C oxidase copper chaperone (COX17) Ank_2 PF12796.7 EMD60398.1 - 0.077 13.6 0.1 0.17 12.5 0.0 1.6 2 0 0 2 2 2 0 Ankyrin repeats (3 copies) LMBR1 PF04791.16 EMD60399.1 - 2e-118 396.5 3.8 2.4e-118 396.3 3.8 1.0 1 0 0 1 1 1 1 LMBR1-like membrane protein Glutaredoxin PF00462.24 EMD60400.1 - 6.7e-18 64.7 0.0 8.9e-18 64.3 0.0 1.2 1 0 0 1 1 1 1 Glutaredoxin DUF836 PF05768.14 EMD60400.1 - 0.0064 16.9 0.0 0.0082 16.5 0.0 1.4 1 1 0 1 1 1 1 Glutaredoxin-like domain (DUF836) Thioredoxin_2 PF13098.6 EMD60400.1 - 0.019 15.4 0.2 0.049 14.1 0.2 1.7 1 1 0 1 1 1 0 Thioredoxin-like domain Inos-1-P_synth PF01658.17 EMD60400.1 - 0.064 13.5 0.1 4.2 7.7 0.0 2.1 2 0 0 2 2 2 0 Myo-inositol-1-phosphate synthase HEAT PF02985.22 EMD60401.1 - 7.6e-41 134.6 16.9 0.016 15.4 0.0 13.3 14 0 0 14 14 14 12 HEAT repeat HEAT_2 PF13646.6 EMD60401.1 - 6.3e-37 125.8 6.1 3e-11 43.5 0.0 8.5 3 3 6 9 9 9 8 HEAT repeats Cnd1 PF12717.7 EMD60401.1 - 3.2e-13 50.0 9.4 0.0044 17.1 0.0 6.2 6 1 1 7 7 7 3 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 EMD60401.1 - 5.4e-12 46.2 3.3 0.00033 21.2 0.1 7.2 5 3 5 10 10 10 2 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 EMD60401.1 - 8.1e-12 45.4 6.5 0.025 15.1 0.1 8.8 7 3 3 10 10 10 2 HEAT-like repeat Adaptin_N PF01602.20 EMD60401.1 - 3.9e-08 32.3 3.0 2.9e-07 29.4 0.8 3.1 2 1 1 3 3 3 1 Adaptin N terminal region RTP1_C1 PF10363.9 EMD60401.1 - 4.6e-07 30.0 5.9 0.26 11.5 0.1 4.8 4 1 1 5 5 5 3 Required for nuclear transport of RNA pol II C-terminus 1 CLASP_N PF12348.8 EMD60401.1 - 0.002 17.8 2.4 0.91 9.0 0.0 4.6 4 2 1 5 5 5 1 CLASP N terminal Arm PF00514.23 EMD60401.1 - 0.0048 16.9 1.3 2.1 8.5 0.0 4.4 6 0 0 6 6 4 1 Armadillo/beta-catenin-like repeat TetR_C_16 PF17920.1 EMD60401.1 - 0.026 14.7 0.4 7.4 6.9 0.0 3.8 2 1 1 3 3 3 0 Tetracyclin repressor-like, C-terminal domain Proteasom_PSMB PF10508.9 EMD60401.1 - 0.066 11.7 3.3 2.4 6.6 0.6 2.3 2 0 0 2 2 2 0 Proteasome non-ATPase 26S subunit Ecm29 PF13001.7 EMD60401.1 - 0.12 11.1 4.5 10 4.7 0.1 4.1 4 1 0 4 4 4 0 Proteasome stabiliser IFRD PF05004.13 EMD60401.1 - 0.12 11.5 2.1 1.9 7.5 0.1 3.3 3 2 1 4 4 4 0 Interferon-related developmental regulator (IFRD) AA_permease_2 PF13520.6 EMD60402.1 - 2.8e-54 184.6 22.9 3.4e-54 184.3 22.9 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EMD60402.1 - 4.6e-21 75.0 22.4 8.6e-21 74.1 22.3 1.5 1 1 0 1 1 1 1 Amino acid permease Hydrophobin_2 PF06766.11 EMD60403.1 - 1.3e-25 89.1 13.9 1.8e-25 88.7 13.9 1.1 1 0 0 1 1 1 1 Fungal hydrophobin Pkinase PF00069.25 EMD60407.1 - 2.1e-64 217.4 0.0 2.5e-64 217.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD60407.1 - 3.7e-36 124.7 0.0 4.8e-36 124.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMD60407.1 - 4e-07 29.6 0.0 6.3e-07 29.0 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EMD60407.1 - 9.6e-05 21.3 0.0 0.00014 20.8 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase DUF4690 PF15756.5 EMD60407.1 - 0.037 14.6 1.6 2.3 8.9 0.2 2.8 1 1 1 2 2 2 0 Small Novel Rich in Cartilage FTA2 PF13095.6 EMD60407.1 - 0.05 13.2 0.0 0.42 10.2 0.0 2.0 1 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 EMD60407.1 - 0.095 12.6 0.0 0.3 11.0 0.0 1.8 1 1 1 2 2 2 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 EMD60407.1 - 0.18 10.8 0.1 0.27 10.3 0.1 1.1 1 0 0 1 1 1 0 Seadornavirus VP7 Kdo PF06293.14 EMD60407.1 - 0.2 11.0 0.0 0.32 10.3 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family tRNA_synthFbeta PF17759.1 EMD60408.1 - 2.2e-45 154.8 0.0 3.1e-45 154.2 0.0 1.2 1 0 0 1 1 1 1 Phenylalanyl tRNA synthetase beta chain CLM domain PhetRS_B1 PF18262.1 EMD60408.1 - 1.3e-32 111.9 0.5 6.8e-31 106.3 0.1 2.7 2 1 0 2 2 2 1 Phe-tRNA synthetase beta subunit B1 domain B3_4 PF03483.17 EMD60408.1 - 1.5e-24 86.6 0.0 2.6e-24 85.8 0.0 1.4 1 0 0 1 1 1 1 B3/4 domain B5 PF03484.15 EMD60408.1 - 2e-19 69.6 0.0 1.3e-17 63.8 0.0 2.5 2 0 0 2 2 2 1 tRNA synthetase B5 domain Glyco_hydro_1 PF00232.18 EMD60409.1 - 1.5e-66 224.7 1.6 1.7e-63 214.6 1.6 2.9 1 1 0 1 1 1 1 Glycosyl hydrolase family 1 GFO_IDH_MocA PF01408.22 EMD60411.1 - 3.1e-23 82.9 0.0 4.9e-23 82.2 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold F420_oxidored PF03807.17 EMD60411.1 - 0.026 15.1 0.0 0.06 13.9 0.0 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Sdh5 PF03937.16 EMD60412.1 - 1.6e-23 82.5 0.1 3.3e-23 81.4 0.1 1.5 1 0 0 1 1 1 1 Flavinator of succinate dehydrogenase MRP-S31 PF15433.6 EMD60412.1 - 0.074 12.7 0.1 0.11 12.2 0.1 1.4 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S31 Glyco_hydro_53 PF07745.13 EMD60413.1 - 4e-104 348.3 0.0 4.5e-104 348.1 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 53 Ribosomal_S3_C PF00189.20 EMD60414.1 - 8.5e-25 87.1 0.1 4.6e-24 84.7 0.1 2.1 2 0 0 2 2 2 1 Ribosomal protein S3, C-terminal domain KH_2 PF07650.17 EMD60414.1 - 6.4e-12 45.1 0.1 1.2e-11 44.3 0.1 1.5 1 0 0 1 1 1 1 KH domain UN_NPL4 PF11543.8 EMD60414.1 - 0.11 13.1 0.0 0.2 12.2 0.0 1.5 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 Coilin_N PF15862.5 EMD60414.1 - 0.11 12.3 0.1 0.34 10.7 0.0 1.7 2 0 0 2 2 2 0 Coilin N-terminus EamA PF00892.20 EMD60415.1 - 2.7e-11 43.8 23.2 1e-05 25.7 14.1 2.4 2 0 0 2 2 2 2 EamA-like transporter family Nuc_sug_transp PF04142.15 EMD60415.1 - 6.2e-10 38.7 0.6 1e-09 38.0 0.6 1.5 1 1 0 1 1 1 1 Nucleotide-sugar transporter TPT PF03151.16 EMD60415.1 - 2.7e-05 23.7 9.6 0.00019 20.9 0.1 2.4 2 0 0 2 2 2 2 Triose-phosphate Transporter family UAA PF08449.11 EMD60415.1 - 4.1e-05 22.9 12.1 4.1e-05 22.9 12.1 1.6 2 0 0 2 2 2 1 UAA transporter family Tom5 PF10642.9 EMD60415.1 - 0.12 12.5 0.7 16 5.6 0.0 2.6 2 0 0 2 2 2 0 Mitochondrial import receptor subunit or translocase MFS_1 PF07690.16 EMD60416.1 - 3.2e-40 138.1 15.9 3.2e-40 138.1 15.9 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily ZapB PF06005.12 EMD60417.1 - 0.8 10.2 10.2 0.68 10.4 6.0 2.2 1 1 1 2 2 2 0 Cell division protein ZapB Zn_clus PF00172.18 EMD60418.1 - 5.5e-07 29.6 12.6 5.5e-07 29.6 12.6 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF4106 PF13388.6 EMD60418.1 - 2 7.5 6.7 0.51 9.5 1.9 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4106) Nucleotid_trans PF03407.16 EMD60420.1 - 3.4e-09 37.0 0.1 7.1e-09 35.9 0.1 1.5 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase Glyco_transf_34 PF05637.12 EMD60420.1 - 3.3e-07 30.3 2.1 1.1e-06 28.6 2.1 1.7 1 1 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family DUF2947 PF11163.8 EMD60420.1 - 0.088 12.7 0.1 0.13 12.1 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2947) Zn_clus PF00172.18 EMD60421.1 - 3.5e-10 39.8 9.1 6.3e-10 39.0 9.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EMD60421.1 - 1.5e-07 30.7 0.2 2.7e-07 29.9 0.2 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain F-box-like PF12937.7 EMD60422.1 - 0.00011 22.0 0.0 0.00038 20.3 0.0 1.9 2 0 0 2 2 2 1 F-box-like PALP PF00291.25 EMD60423.1 - 6.3e-65 219.5 1.0 8.1e-65 219.1 1.0 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme NdhS PF11623.8 EMD60423.1 - 0.14 11.9 0.3 0.4 10.4 0.3 1.7 1 0 0 1 1 1 0 NAD(P)H dehydrogenase subunit S Peptidase_S10 PF00450.22 EMD60424.1 - 5.8e-82 276.3 0.1 7.1e-82 276.0 0.1 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase Pro-kuma_activ PF09286.11 EMD60425.1 - 5.1e-38 130.6 0.0 1.2e-37 129.4 0.0 1.7 1 0 0 1 1 1 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 EMD60425.1 - 2.2e-06 27.2 0.0 4.5e-06 26.1 0.0 1.5 1 0 0 1 1 1 1 Subtilase family HAD_2 PF13419.6 EMD60426.1 - 6.5e-16 58.9 0.0 1.5e-15 57.8 0.0 1.6 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EMD60426.1 - 1.1e-10 42.1 0.0 1.9e-07 31.6 0.0 2.2 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EMD60426.1 - 5.5e-07 29.6 0.4 1.8e-06 27.9 0.4 1.8 2 0 0 2 2 2 1 HAD-hyrolase-like PGP_phosphatase PF09419.10 EMD60426.1 - 0.0014 18.2 0.0 0.75 9.4 0.0 3.0 3 0 0 3 3 3 1 Mitochondrial PGP phosphatase HAD PF12710.7 EMD60426.1 - 0.0023 18.3 0.0 0.022 15.2 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Acid_phosphat_B PF03767.14 EMD60426.1 - 0.088 12.4 0.1 9.8 5.7 0.0 2.6 2 1 0 2 2 2 0 HAD superfamily, subfamily IIIB (Acid phosphatase) Glyco_hydro_18 PF00704.28 EMD60427.1 - 1.4e-69 235.2 7.8 1.7e-69 235.0 7.8 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 DBC1 PF14443.6 EMD60427.1 - 0.1 12.5 0.2 0.27 11.2 0.2 1.6 1 1 0 1 1 1 0 DBC1 Glyco_hydro_28 PF00295.17 EMD60429.1 - 3.6e-129 430.5 26.3 4.1e-129 430.3 26.3 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 Melibiase PF02065.18 EMD60430.1 - 5.3e-142 472.9 0.0 6.6e-142 472.5 0.0 1.1 1 0 0 1 1 1 1 Melibiase Glyco_hydro_36N PF16875.5 EMD60430.1 - 3.4e-76 256.2 0.0 6.5e-76 255.2 0.0 1.5 2 0 0 2 2 2 1 Glycosyl hydrolase family 36 N-terminal domain Scs3p PF10261.9 EMD60430.1 - 1.7e-73 247.2 4.0 2.3e-73 246.7 4.0 1.2 1 0 0 1 1 1 1 Inositol phospholipid synthesis and fat-storage-inducing TM Glyco_hydro_36C PF16874.5 EMD60430.1 - 1.4e-23 83.1 0.0 2.9e-23 82.2 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 36 C-terminal domain GHL10 PF02638.15 EMD60430.1 - 3.7e-05 23.0 0.1 6.3e-05 22.2 0.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase-like 10 LVIVD PF08309.11 EMD60431.1 - 0.0019 17.5 2.3 0.75 9.2 1.1 3.6 4 0 0 4 4 4 2 LVIVD repeat Fungal_trans PF04082.18 EMD60432.1 - 1.4e-26 93.1 0.0 2.5e-26 92.3 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD60432.1 - 1.7e-08 34.4 7.4 2.8e-08 33.7 7.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Ribosomal_L13 PF00572.18 EMD60433.1 - 5.4e-09 36.4 0.0 4.5e-07 30.2 0.0 2.3 1 1 0 1 1 1 1 Ribosomal protein L13 AMP-binding PF00501.28 EMD60434.1 - 6.7e-75 252.3 0.0 8.5e-75 251.9 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EMD60434.1 - 8.5e-20 71.5 0.1 2.4e-19 70.1 0.1 1.8 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain UAA PF08449.11 EMD60435.1 - 3.4e-42 144.7 14.7 5.2e-42 144.1 14.7 1.2 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 EMD60435.1 - 2.8e-06 27.5 28.2 0.00096 19.3 9.3 3.3 2 2 1 3 3 3 2 EamA-like transporter family Nuc_sug_transp PF04142.15 EMD60435.1 - 0.00035 19.9 2.0 0.024 13.8 0.1 2.2 2 0 0 2 2 2 2 Nucleotide-sugar transporter UPF0060 PF02694.15 EMD60435.1 - 0.04 14.1 0.5 0.04 14.1 0.5 2.5 3 1 0 3 3 3 0 Uncharacterised BCR, YnfA/UPF0060 family KH_1 PF00013.29 EMD60437.1 - 1.4e-41 140.1 7.5 1.3e-17 63.3 0.1 3.2 3 0 0 3 3 3 3 KH domain KH_2 PF07650.17 EMD60437.1 - 2e-10 40.3 10.5 0.0032 17.3 1.3 3.4 3 1 0 3 3 3 3 KH domain KH_4 PF13083.6 EMD60437.1 - 1.1e-08 34.8 6.1 0.028 14.3 0.3 3.3 3 0 0 3 3 3 3 KH domain KH_5 PF13184.6 EMD60437.1 - 9.5e-05 22.4 6.0 0.18 11.9 0.1 3.3 3 0 0 3 3 3 2 NusA-like KH domain ECF-ribofla_trS PF07155.12 EMD60437.1 - 0.12 12.3 0.0 0.25 11.3 0.0 1.5 1 0 0 1 1 1 0 ECF-type riboflavin transporter, S component ADH_N PF08240.12 EMD60438.1 - 4.4e-29 100.5 1.8 4.4e-29 100.5 1.8 1.6 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EMD60438.1 - 7e-16 58.4 0.0 1e-15 57.8 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EMD60438.1 - 0.0003 20.3 0.0 0.00051 19.6 0.0 1.3 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_N_assoc PF13823.6 EMD60438.1 - 0.001 19.0 0.6 0.001 19.0 0.6 2.2 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-associated Yippee-Mis18 PF03226.14 EMD60439.1 - 5.5e-16 58.7 0.5 6.8e-16 58.4 0.5 1.1 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly RIG-I_C-RD PF11648.8 EMD60439.1 - 0.00079 19.6 0.7 0.0013 19.0 0.7 1.3 1 0 0 1 1 1 1 C-terminal domain of RIG-I Zn_ribbon_SprT PF17283.2 EMD60439.1 - 0.048 13.6 3.0 2.1 8.3 0.3 2.4 2 0 0 2 2 2 0 SprT-like zinc ribbon domain Evr1_Alr PF04777.13 EMD60439.1 - 0.15 12.5 0.6 3.5 8.2 0.1 2.1 1 1 1 2 2 2 0 Erv1 / Alr family TPR_1 PF00515.28 EMD60440.1 - 1.1e-40 135.8 19.7 3.3e-07 29.8 0.0 8.2 8 1 1 9 9 8 7 Tetratricopeptide repeat TPR_2 PF07719.17 EMD60440.1 - 2.4e-36 120.9 18.7 1.6e-06 27.8 0.1 8.3 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_11 PF13414.6 EMD60440.1 - 3e-28 97.2 17.8 2.2e-09 36.8 1.3 7.5 6 1 2 8 8 7 5 TPR repeat TPR_19 PF14559.6 EMD60440.1 - 4.3e-28 97.6 17.4 5.6e-06 26.8 0.2 5.9 4 2 2 6 6 6 5 Tetratricopeptide repeat DnaJ PF00226.31 EMD60440.1 - 7.8e-27 93.2 4.6 2.6e-26 91.5 4.6 2.0 1 0 0 1 1 1 1 DnaJ domain TPR_16 PF13432.6 EMD60440.1 - 1.4e-25 89.6 3.0 2e-05 25.2 0.0 5.7 4 1 1 5 5 5 5 Tetratricopeptide repeat TPR_14 PF13428.6 EMD60440.1 - 3.9e-20 70.8 12.7 0.0017 19.0 0.1 8.2 6 2 3 9 9 7 5 Tetratricopeptide repeat TPR_8 PF13181.6 EMD60440.1 - 1.4e-19 68.6 14.9 0.014 15.5 0.0 7.5 7 1 1 8 8 7 6 Tetratricopeptide repeat TPR_9 PF13371.6 EMD60440.1 - 4.8e-17 61.9 4.9 1.8e-06 28.0 0.1 4.9 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_12 PF13424.6 EMD60440.1 - 1.6e-16 60.3 11.5 2.1e-05 24.7 0.5 6.4 4 2 2 6 6 5 4 Tetratricopeptide repeat ANAPC3 PF12895.7 EMD60440.1 - 3.3e-16 59.3 7.3 5.6e-06 26.5 0.5 3.9 2 1 2 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 EMD60440.1 - 7.6e-15 54.2 18.2 0.0022 18.3 0.6 7.3 8 0 0 8 8 7 4 Tetratricopeptide repeat TPR_7 PF13176.6 EMD60440.1 - 2.2e-13 49.2 9.5 0.049 13.7 0.0 7.1 7 1 0 7 7 6 4 Tetratricopeptide repeat TPR_6 PF13174.6 EMD60440.1 - 1.1e-10 41.5 9.1 0.21 12.3 0.2 7.7 7 1 1 8 8 7 2 Tetratricopeptide repeat TPR_10 PF13374.6 EMD60440.1 - 4.8e-10 39.0 16.4 0.14 12.1 0.2 6.7 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_15 PF13429.6 EMD60440.1 - 2.1e-08 33.7 7.8 0.031 13.5 0.0 4.8 2 2 3 5 5 5 2 Tetratricopeptide repeat TPR_4 PF07721.14 EMD60440.1 - 4.6e-07 29.8 1.1 0.19 12.5 0.1 4.6 6 0 0 6 6 3 2 Tetratricopeptide repeat TPR_20 PF14561.6 EMD60440.1 - 5.7e-06 26.6 10.0 0.45 10.9 0.1 5.0 3 3 2 5 5 5 3 Tetratricopeptide repeat BTAD PF03704.17 EMD60440.1 - 5.4e-05 23.7 6.4 1.6 9.2 0.7 4.6 3 2 1 4 4 4 2 Bacterial transcriptional activator domain Alkyl_sulf_dimr PF14863.6 EMD60440.1 - 7e-05 23.3 1.3 0.47 10.9 0.6 3.9 2 1 1 3 3 3 1 Alkyl sulfatase dimerisation Fis1_TPR_C PF14853.6 EMD60440.1 - 0.00014 21.8 10.6 0.42 10.7 0.0 5.6 4 2 2 6 6 5 1 Fis1 C-terminal tetratricopeptide repeat TPR_MalT PF17874.1 EMD60440.1 - 0.00062 19.2 1.7 0.97 8.7 0.1 3.5 2 1 1 4 4 4 1 MalT-like TPR region DUF3597 PF12200.8 EMD60440.1 - 0.0017 18.9 0.2 0.0017 18.9 0.2 2.7 2 1 0 2 2 1 1 Domain of unknown function (DUF3597) DUF3808 PF10300.9 EMD60440.1 - 0.0023 16.8 0.3 0.037 12.8 0.1 2.6 3 0 0 3 3 3 1 Protein of unknown function (DUF3808) HrpB1_HrpK PF09613.10 EMD60440.1 - 0.0034 17.0 1.3 6 6.5 0.1 3.8 2 1 2 4 4 4 0 Bacterial type III secretion protein (HrpB1_HrpK) PPR PF01535.20 EMD60440.1 - 0.0069 16.6 1.6 9.2 6.8 0.0 4.4 5 0 0 5 5 3 0 PPR repeat MIT PF04212.18 EMD60440.1 - 0.01 15.9 4.4 1.3 9.1 0.1 4.4 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain DUF928 PF06051.12 EMD60440.1 - 0.031 14.1 0.9 0.45 10.4 0.1 2.5 2 0 0 2 2 2 0 Domain of Unknown Function (DUF928) TPR_21 PF09976.9 EMD60440.1 - 0.06 13.0 9.6 2.3 7.9 0.1 4.8 2 2 3 6 6 6 0 Tetratricopeptide repeat-like domain ChAPs PF09295.10 EMD60440.1 - 0.12 11.3 1.1 3 6.8 0.0 2.7 3 0 0 3 3 3 0 ChAPs (Chs5p-Arf1p-binding proteins) TOM20_plant PF06552.12 EMD60440.1 - 0.14 11.9 1.8 5.3 6.7 0.3 3.5 2 1 1 3 3 3 0 Plant specific mitochondrial import receptor subunit TOM20 TPR_3 PF07720.12 EMD60440.1 - 0.24 11.4 2.1 1.9 8.5 0.1 3.3 4 0 0 4 4 3 0 Tetratricopeptide repeat LemA PF04011.12 EMD60440.1 - 0.56 10.0 4.3 0.44 10.4 0.3 2.6 2 1 1 3 3 3 0 LemA family DUF2196 PF09962.9 EMD60441.1 - 5.4e-23 80.7 0.2 9.8e-23 79.9 0.2 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2196) PARG_cat PF05028.14 EMD60442.1 - 0.0027 17.0 1.0 0.0041 16.5 0.5 1.5 1 1 0 1 1 1 1 Poly (ADP-ribose) glycohydrolase (PARG) Cep57_CLD_2 PF14197.6 EMD60442.1 - 0.021 14.9 2.8 0.021 14.9 2.8 4.3 3 1 0 4 4 4 0 Centrosome localisation domain of PPC89 BLOC1_2 PF10046.9 EMD60442.1 - 0.022 15.0 1.5 0.022 15.0 1.5 3.6 2 2 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Med9 PF07544.13 EMD60442.1 - 0.043 13.9 6.3 0.5 10.5 1.3 4.0 3 2 0 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 KLRAQ PF10205.9 EMD60442.1 - 0.054 13.7 14.4 0.2 11.9 6.5 2.7 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein FlaC_arch PF05377.11 EMD60442.1 - 0.11 12.9 11.7 0.43 11.0 1.7 3.9 2 2 0 3 3 3 0 Flagella accessory protein C (FlaC) GAS PF13851.6 EMD60442.1 - 0.31 10.4 24.2 2.1 7.6 11.3 3.2 2 2 0 2 2 2 0 Growth-arrest specific micro-tubule binding DUF1664 PF07889.12 EMD60442.1 - 0.63 10.1 12.8 0.46 10.5 2.6 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) KASH_CCD PF14662.6 EMD60442.1 - 0.85 9.4 21.2 1.2 8.9 4.4 2.5 2 0 0 2 2 2 0 Coiled-coil region of CCDC155 or KASH PRKG1_interact PF15898.5 EMD60442.1 - 1.1 10.3 23.1 0.26 12.2 9.6 2.9 2 1 0 2 2 2 0 cGMP-dependent protein kinase interacting domain ZapB PF06005.12 EMD60442.1 - 1.5 9.3 23.6 0.42 11.1 0.2 4.3 3 2 0 3 3 3 0 Cell division protein ZapB Tropomyosin_1 PF12718.7 EMD60442.1 - 4.1 7.5 24.7 1.5 8.9 7.6 2.7 2 1 0 2 2 2 0 Tropomyosin like DUF724 PF05266.14 EMD60442.1 - 4.4 7.1 20.0 0.067 13.0 4.1 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF724) TMPIT PF07851.13 EMD60442.1 - 4.7 6.4 10.0 1.3 8.1 3.2 2.3 2 0 0 2 2 2 0 TMPIT-like protein APG6_N PF17675.1 EMD60442.1 - 5.2 7.6 26.7 0.44 11.1 8.4 2.9 3 1 0 3 3 2 0 Apg6 coiled-coil region DUF641 PF04859.12 EMD60442.1 - 6.1 7.2 15.7 9.7 6.5 2.1 3.7 3 1 1 4 4 4 0 Plant protein of unknown function (DUF641) CENP-F_leu_zip PF10473.9 EMD60442.1 - 6.9 6.7 27.1 0.15 12.1 2.5 3.7 2 2 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 HIP1_clath_bdg PF16515.5 EMD60442.1 - 7.6 7.2 23.3 3.5 8.3 5.1 4.2 2 2 1 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Surp PF01805.20 EMD60444.1 - 0.18 11.8 1.9 0.21 11.6 0.2 1.9 2 0 0 2 2 2 0 Surp module N_BRCA1_IG PF16158.5 EMD60446.1 - 7.1e-34 116.6 0.2 2.9e-33 114.6 0.0 2.2 2 0 0 2 2 2 1 Ig-like domain from next to BRCA1 gene ZZ PF00569.17 EMD60446.1 - 7.8e-18 64.0 58.8 4.6e-06 26.3 6.9 4.3 4 0 0 4 4 4 4 Zinc finger, ZZ type RRM_1 PF00076.22 EMD60447.1 - 1.1e-21 76.4 0.0 3.8e-12 45.8 0.0 3.8 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EMD60447.1 - 7e-05 22.9 0.0 0.22 11.6 0.0 2.7 2 1 0 2 2 2 2 RNA recognition motif HGTP_anticodon2 PF12745.7 EMD60447.1 - 0.64 9.5 10.3 1.2 8.6 10.3 1.4 1 0 0 1 1 1 0 Anticodon binding domain of tRNAs Presenilin PF01080.17 EMD60447.1 - 9.9 4.8 7.7 20 3.8 7.7 1.5 1 0 0 1 1 1 0 Presenilin AIM24 PF01987.17 EMD60448.1 - 1.7e-54 184.7 0.2 2e-54 184.5 0.2 1.0 1 0 0 1 1 1 1 Mitochondrial biogenesis AIM24 eIF-5_eIF-2B PF01873.17 EMD60449.1 - 3.4e-41 139.8 0.3 5.9e-41 139.0 0.3 1.4 1 0 0 1 1 1 1 Domain found in IF2B/IF5 NMD3 PF04981.13 EMD60449.1 - 0.044 13.2 0.4 0.044 13.2 0.4 1.9 2 0 0 2 2 2 0 NMD3 family zf-HYPF PF07503.12 EMD60449.1 - 0.17 11.7 1.0 18 5.2 0.1 2.5 2 0 0 2 2 2 0 HypF finger Vfa1 PF08432.10 EMD60449.1 - 0.37 11.1 7.4 0.59 10.4 7.4 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Rotamase_3 PF13616.6 EMD60451.1 - 1.1e-15 58.2 0.1 2e-15 57.3 0.1 1.5 1 1 0 1 1 1 1 PPIC-type PPIASE domain Rotamase PF00639.21 EMD60451.1 - 1.2e-13 51.8 0.1 2.2e-13 50.9 0.1 1.5 1 1 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_2 PF13145.6 EMD60451.1 - 0.0018 19.1 0.0 0.0023 18.7 0.0 1.3 1 1 0 1 1 1 1 PPIC-type PPIASE domain Ank_2 PF12796.7 EMD60452.1 - 1.8e-17 63.7 0.0 4.9e-09 36.7 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMD60452.1 - 4.8e-11 43.0 0.0 0.014 16.0 0.0 4.1 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EMD60452.1 - 4.6e-08 33.2 0.0 0.052 13.9 0.0 4.3 2 2 2 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 EMD60452.1 - 9.4e-08 32.2 0.2 0.1 13.1 0.1 4.6 3 1 1 4 4 4 2 Ankyrin repeat Ank_3 PF13606.6 EMD60452.1 - 3e-06 27.1 0.1 2.9 8.8 0.0 4.7 4 0 0 4 4 4 2 Ankyrin repeat Steroid_dh PF02544.16 EMD60453.1 - 5e-11 42.8 0.1 9.1e-11 42.0 0.1 1.5 1 1 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase Ku_PK_bind PF08785.11 EMD60454.1 - 3.1e-31 108.0 0.0 9e-31 106.5 0.0 1.9 2 0 0 2 2 2 1 Ku C terminal domain like Ku PF02735.16 EMD60454.1 - 1.9e-30 106.1 0.0 3.1e-30 105.4 0.0 1.3 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain VWA PF00092.28 EMD60454.1 - 0.0079 16.5 0.0 0.021 15.0 0.0 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 EMD60454.1 - 0.048 14.3 0.0 0.21 12.3 0.0 2.2 1 0 0 1 1 1 0 von Willebrand factor type A domain adh_short_C2 PF13561.6 EMD60456.1 - 1.1e-52 178.9 0.1 1.4e-52 178.6 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EMD60456.1 - 9.9e-44 149.1 0.1 1.2e-43 148.8 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EMD60456.1 - 4e-07 30.1 0.0 6e-07 29.5 0.0 1.3 1 0 0 1 1 1 1 KR domain Formyl_trans_N PF00551.19 EMD60457.1 - 1.9e-39 135.3 0.5 2.6e-39 134.8 0.5 1.2 1 0 0 1 1 1 1 Formyl transferase ACT PF01842.25 EMD60457.1 - 2.4e-08 33.6 0.0 6.8e-08 32.1 0.0 1.8 1 0 0 1 1 1 1 ACT domain ACT_6 PF13740.6 EMD60457.1 - 5.3e-06 26.3 0.0 2.5e-05 24.2 0.0 2.1 2 0 0 2 2 2 1 ACT domain MGS PF02142.22 EMD60457.1 - 0.051 13.8 0.0 0.1 12.8 0.0 1.5 1 0 0 1 1 1 0 MGS-like domain SIKE PF05769.11 EMD60458.1 - 1.8e-07 31.3 0.5 3.6e-07 30.3 0.5 1.5 1 0 0 1 1 1 1 SIKE family DivIC PF04977.15 EMD60458.1 - 0.69 9.7 15.3 0.45 10.3 0.1 3.8 4 0 0 4 4 4 0 Septum formation initiator DUF1325 PF07039.11 EMD60459.1 - 1.9e-33 115.3 0.0 4.5e-33 114.1 0.0 1.7 2 0 0 2 2 2 1 SGF29 tudor-like domain Cortex-I_coil PF09304.10 EMD60459.1 - 0.022 15.0 2.8 0.062 13.5 2.8 1.8 1 0 0 1 1 1 0 Cortexillin I, coiled coil PMI_typeI PF01238.21 EMD60460.1 - 3.4e-145 483.9 0.0 4e-145 483.7 0.0 1.0 1 0 0 1 1 1 1 Phosphomannose isomerase type I Cas_TM1802 PF09484.10 EMD60460.1 - 0.0049 15.7 0.2 0.006 15.4 0.2 1.2 1 0 0 1 1 1 1 CRISPR-associated protein TM1802 (cas_TM1802) DUF3813 PF12758.7 EMD60460.1 - 0.012 16.0 2.1 0.027 14.8 2.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3813) Talin_middle PF09141.10 EMD60460.1 - 0.051 13.6 0.4 0.1 12.6 0.4 1.4 1 0 0 1 1 1 0 Talin, middle domain Glyco_transf_8 PF01501.20 EMD60461.1 - 3.9e-15 56.1 0.1 1.4e-14 54.3 0.1 1.7 1 1 0 1 1 1 1 Glycosyl transferase family 8 Nucleotid_trans PF03407.16 EMD60461.1 - 0.0086 16.1 0.0 0.013 15.5 0.0 1.4 1 1 0 1 1 1 1 Nucleotide-diphospho-sugar transferase Mito_carr PF00153.27 EMD60462.1 - 2.7e-55 184.3 0.2 6.7e-19 67.6 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Arf PF00025.21 EMD60463.1 - 1.9e-73 245.6 0.2 2.2e-73 245.4 0.2 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EMD60463.1 - 3.2e-14 53.2 0.1 4.3e-14 52.8 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EMD60463.1 - 2.1e-12 47.0 0.0 2.3e-12 46.8 0.0 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 EMD60463.1 - 2.4e-12 46.6 0.0 3e-12 46.3 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 EMD60463.1 - 2.8e-12 46.5 1.9 2.3e-08 33.6 0.5 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 EMD60463.1 - 5e-11 42.4 0.0 6e-11 42.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EMD60463.1 - 0.00045 20.3 0.1 0.00067 19.7 0.1 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Tachylectin PF14517.6 EMD60463.1 - 0.072 12.6 0.0 0.12 11.9 0.0 1.3 1 1 0 1 1 1 0 Tachylectin 6PF2K PF01591.18 EMD60463.1 - 0.076 12.3 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 6-phosphofructo-2-kinase MobB PF03205.14 EMD60463.1 - 0.083 12.8 0.0 0.12 12.3 0.0 1.2 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Homeodomain PF00046.29 EMD60464.1 - 2.6e-13 49.6 3.4 5.5e-13 48.6 3.4 1.6 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EMD60464.1 - 0.0065 16.4 0.1 0.019 14.8 0.1 1.9 1 0 0 1 1 1 1 Homeobox KN domain NAD_binding_10 PF13460.6 EMD60465.1 - 7.3e-06 26.0 0.0 4.4e-05 23.5 0.0 2.0 2 0 0 2 2 2 1 NAD(P)H-binding NmrA PF05368.13 EMD60465.1 - 4.5e-05 23.1 0.0 0.00037 20.1 0.0 2.0 2 0 0 2 2 2 1 NmrA-like family Sacchrp_dh_NADP PF03435.18 EMD60465.1 - 0.0028 17.9 0.0 0.0083 16.4 0.0 1.7 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 EMD60465.1 - 0.068 13.2 0.2 0.11 12.5 0.2 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase DDE_Tnp_ISAZ013 PF07592.11 EMD60465.1 - 0.091 11.7 0.0 0.14 11.1 0.0 1.2 1 0 0 1 1 1 0 Rhodopirellula transposase DDE domain COPIIcoated_ERV PF07970.12 EMD60469.1 - 2.4e-32 112.6 0.1 3.5e-32 112.0 0.1 1.2 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 EMD60469.1 - 1.6e-21 76.4 0.4 4.8e-21 74.9 0.1 1.9 2 0 0 2 2 2 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) TM140 PF14985.6 EMD60469.1 - 0.066 12.8 0.0 0.1 12.1 0.0 1.2 1 0 0 1 1 1 0 TM140 protein family Peptidase_S26 PF10502.9 EMD60470.1 - 1.3e-05 25.0 0.0 3.2e-05 23.7 0.0 1.7 1 1 0 1 1 1 1 Signal peptidase, peptidase S26 Peptidase_S24 PF00717.23 EMD60470.1 - 0.009 15.9 0.1 0.075 13.0 0.1 2.4 1 1 1 2 2 2 1 Peptidase S24-like Cupin_8 PF13621.6 EMD60471.1 - 9.8e-65 218.8 0.1 1.1e-64 218.6 0.1 1.0 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 EMD60471.1 - 0.00036 20.1 0.0 0.04 13.4 0.0 2.6 3 0 0 3 3 3 2 Cupin superfamily protein NECFESHC PF16621.5 EMD60472.1 - 0.0033 17.3 0.5 0.0033 17.3 0.5 3.7 3 0 0 3 3 3 1 SH3 terminal domain of 2nd SH3 on Neutrophil cytosol factor 1 DNA_ligase_A_M PF01068.21 EMD60473.1 - 9.4e-45 152.8 0.7 2.8e-44 151.2 0.0 2.2 3 0 0 3 3 3 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 EMD60473.1 - 1.7e-44 152.2 0.1 5.8e-44 150.4 0.0 1.9 2 0 0 2 2 2 1 DNA ligase N terminus BRCT_2 PF16589.5 EMD60473.1 - 8.3e-18 64.6 0.0 3.7e-13 49.7 0.0 2.6 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain RNA_ligase PF09414.10 EMD60473.1 - 2.1e-16 60.7 0.1 5.2e-16 59.4 0.1 1.7 1 0 0 1 1 1 1 RNA ligase DNA_ligase_A_C PF04679.15 EMD60473.1 - 4.3e-16 59.3 0.0 1.6e-15 57.5 0.0 2.1 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region LIG3_BRCT PF16759.5 EMD60473.1 - 2e-07 31.2 0.1 0.015 15.6 0.1 2.7 2 0 0 2 2 2 2 DNA ligase 3 BRCT domain BRCT PF00533.26 EMD60473.1 - 5.1e-06 26.8 0.1 5.4e-05 23.5 0.0 2.5 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain Complex1_49kDa PF00346.19 EMD60473.1 - 0.07 12.2 0.0 0.15 11.1 0.0 1.5 1 0 0 1 1 1 0 Respiratory-chain NADH dehydrogenase, 49 Kd subunit DNA_ligase_IV PF11411.8 EMD60473.1 - 0.073 13.2 0.3 11 6.2 0.1 2.6 2 0 0 2 2 2 0 DNA ligase IV Bac_globin PF01152.21 EMD60473.1 - 0.081 13.1 0.0 0.26 11.4 0.0 1.9 1 0 0 1 1 1 0 Bacterial-like globin nec1 PF10379.9 EMD60474.1 - 0.12 11.8 0.2 0.4 10.2 0.1 1.8 1 1 1 2 2 2 0 Virulence protein nec1 Snf7 PF03357.21 EMD60476.1 - 2.3e-36 125.0 19.2 2.3e-36 125.0 19.2 1.9 1 1 1 2 2 2 1 Snf7 YlqD PF11068.8 EMD60476.1 - 0.67 10.3 17.8 1.7 9.0 6.6 2.2 1 1 1 2 2 2 0 YlqD protein DUF3958 PF13125.6 EMD60476.1 - 6.3 7.1 13.8 0.13 12.5 3.8 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF3958) Dynamin_N PF00350.23 EMD60477.1 - 1.1e-14 54.8 0.1 4.9e-14 52.7 0.0 2.2 2 1 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.23 EMD60477.1 - 1.3e-09 38.1 0.0 4.3e-09 36.5 0.0 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase zf-rbx1 PF12678.7 EMD60477.1 - 4e-08 33.4 1.1 7.9e-08 32.5 1.1 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 EMD60477.1 - 6.3e-07 29.6 1.8 6.3e-07 29.6 1.8 2.4 3 0 0 3 3 2 1 Ring finger domain GTP_EFTU PF00009.27 EMD60477.1 - 9e-06 25.4 0.6 0.00014 21.5 0.5 2.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain zf-C3HC4 PF00097.25 EMD60477.1 - 0.00013 21.7 1.2 0.00025 20.8 1.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EMD60477.1 - 0.00019 21.3 1.0 0.00047 20.1 1.0 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 EMD60477.1 - 0.00074 19.3 1.4 0.00074 19.3 1.4 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) DUF2921 PF11145.8 EMD60477.1 - 0.0014 16.6 2.0 0.22 9.3 1.4 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF2921) zf-RING_UBOX PF13445.6 EMD60477.1 - 0.0029 17.6 0.2 0.0099 15.9 0.2 1.9 1 1 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.6 EMD60477.1 - 0.0038 17.0 1.3 0.0095 15.8 1.3 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_11 PF17123.5 EMD60477.1 - 0.0044 16.7 4.3 0.047 13.4 0.2 2.5 2 0 0 2 2 2 1 RING-like zinc finger Zn_ribbon_17 PF17120.5 EMD60477.1 - 0.0088 15.6 0.3 0.019 14.5 0.3 1.5 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type DUF2205 PF10224.9 EMD60477.1 - 0.019 15.0 0.3 0.059 13.4 0.3 1.8 1 0 0 1 1 1 0 Short coiled-coil protein cobW PF02492.19 EMD60477.1 - 0.043 13.4 0.3 0.67 9.5 0.4 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain IIGP PF05049.13 EMD60477.1 - 0.062 12.4 0.0 0.11 11.5 0.0 1.3 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) zf-C3HC4_3 PF13920.6 EMD60477.1 - 0.081 12.8 4.6 0.023 14.6 1.1 1.8 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EMD60477.1 - 0.27 11.3 1.0 0.6 10.2 1.0 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger OAD_gamma PF04277.13 EMD60477.1 - 4.8 7.8 6.5 23 5.7 0.0 3.1 1 1 1 2 2 2 0 Oxaloacetate decarboxylase, gamma chain Rhomboid PF01694.22 EMD60478.1 - 1.4e-37 129.0 6.4 1.4e-37 129.0 6.4 1.9 2 0 0 2 2 2 1 Rhomboid family DUF3792 PF12670.7 EMD60478.1 - 1.2 9.3 14.2 0.33 11.1 0.4 2.9 3 1 0 3 3 3 0 Protein of unknown function (DUF3792) zf-C2H2_4 PF13894.6 EMD60479.1 - 5.1e-09 36.2 37.8 0.02 15.7 0.1 7.1 7 0 0 7 7 7 4 C2H2-type zinc finger zf-C2H2 PF00096.26 EMD60479.1 - 2.7e-07 30.7 36.0 0.16 12.5 1.7 6.9 7 0 0 7 7 7 5 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 EMD60479.1 - 0.00054 19.9 19.0 0.092 12.8 0.2 5.4 4 1 1 5 5 5 2 C2H2-type zinc finger zf-met PF12874.7 EMD60479.1 - 0.035 14.5 14.5 0.85 10.1 1.4 4.9 6 0 0 6 6 6 0 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.5 EMD60479.1 - 0.044 13.6 0.2 0.044 13.6 0.2 2.9 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-C2H2_9 PF16293.5 EMD60479.1 - 0.1 12.4 10.7 13 5.7 0.1 4.8 3 2 2 5 5 5 0 C2H2 type zinc-finger (1 copy) zf-H2C2_2 PF13465.6 EMD60479.1 - 0.13 12.8 35.5 0.076 13.5 1.6 6.3 6 0 0 6 6 6 0 Zinc-finger double domain zf-C2H2_2 PF12756.7 EMD60479.1 - 0.2 12.0 30.3 1.8 8.9 0.4 5.3 2 2 3 5 5 5 0 C2H2 type zinc-finger (2 copies) zf-BED PF02892.15 EMD60479.1 - 0.22 11.6 0.1 0.22 11.6 0.1 4.0 3 1 0 3 3 3 0 BED zinc finger zf-C2H2_jaz PF12171.8 EMD60479.1 - 0.96 9.8 20.7 1.7 9.0 1.0 5.7 6 0 0 6 6 6 0 Zinc-finger double-stranded RNA-binding zf-C2H2_8 PF15909.5 EMD60479.1 - 1.2 9.5 18.7 9.3 6.6 0.3 4.2 2 1 1 4 4 4 0 C2H2-type zinc ribbon Cyanate_lyase PF02560.14 EMD60480.1 - 1.5e-34 117.6 0.0 2.3e-34 117.1 0.0 1.3 1 0 0 1 1 1 1 Cyanate lyase C-terminal domain HTH_19 PF12844.7 EMD60480.1 - 4.9e-05 23.3 0.0 0.00015 21.7 0.0 1.7 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_3 PF01381.22 EMD60480.1 - 0.00051 20.0 0.0 0.00092 19.2 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix PLDc_2 PF13091.6 EMD60481.1 - 4e-18 65.6 0.0 1.1e-06 28.6 0.0 4.0 3 1 0 3 3 3 3 PLD-like domain PLDc PF00614.22 EMD60481.1 - 7.6e-12 44.9 1.4 2.3e-05 24.4 0.2 2.5 2 0 0 2 2 2 2 Phospholipase D Active site motif DUF3431 PF11913.8 EMD60482.1 - 1.4e-87 293.0 0.1 2.3e-87 292.3 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3431) TrpP PF17099.5 EMD60482.1 - 0.17 11.6 0.0 0.29 10.9 0.0 1.2 1 0 0 1 1 1 0 Tryptophan transporter TrpP Patatin PF01734.22 EMD60483.1 - 2.2e-12 47.6 0.2 4.9e-12 46.5 0.2 1.6 1 0 0 1 1 1 1 Patatin-like phospholipase ABC_tran PF00005.27 EMD60483.1 - 1.2e-05 25.9 0.0 3.7e-05 24.3 0.0 1.9 1 0 0 1 1 1 1 ABC transporter RsgA_GTPase PF03193.16 EMD60483.1 - 0.0013 18.7 0.0 0.0027 17.6 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase MMR_HSR1 PF01926.23 EMD60483.1 - 0.0022 18.0 0.0 0.016 15.3 0.0 2.4 1 1 1 2 2 2 1 50S ribosome-binding GTPase Zeta_toxin PF06414.12 EMD60483.1 - 0.0075 15.6 0.0 0.017 14.4 0.0 1.6 1 0 0 1 1 1 1 Zeta toxin AAA_22 PF13401.6 EMD60483.1 - 0.012 15.9 0.0 0.03 14.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain Katanin_con80 PF13925.6 EMD60483.1 - 0.056 13.5 0.0 0.73 9.9 0.1 2.5 2 0 0 2 2 2 0 con80 domain of Katanin AAA_29 PF13555.6 EMD60483.1 - 0.058 13.1 0.0 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Rsa3 PF14615.6 EMD60483.1 - 0.095 12.3 0.1 8.1 6.1 0.0 2.6 2 0 0 2 2 2 0 Ribosome-assembly protein 3 PCYCGC PF13798.6 EMD60483.1 - 0.11 12.4 0.2 0.21 11.4 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function with PCYCGC motif AAA_23 PF13476.6 EMD60483.1 - 0.21 12.1 2.3 1.2 9.6 0.0 2.7 3 0 0 3 3 3 0 AAA domain F-box PF00646.33 EMD60485.1 - 0.004 17.0 0.4 0.0091 15.9 0.4 1.6 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EMD60485.1 - 0.093 12.6 0.4 0.24 11.3 0.4 1.7 1 0 0 1 1 1 0 F-box-like F-box_4 PF15966.5 EMD60485.1 - 0.11 12.4 0.0 0.21 11.5 0.0 1.5 1 0 0 1 1 1 0 F-box Ino80_Iec3 PF14612.6 EMD60486.1 - 0.036 14.7 2.3 0.05 14.3 2.3 1.2 1 0 0 1 1 1 0 IEC3 subunit of the Ino80 complex, chromatin re-modelling RAP1 PF07218.11 EMD60486.1 - 9.8 4.3 8.9 12 4.1 8.9 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Amino_oxidase PF01593.24 EMD60487.1 - 4.7e-51 174.5 0.0 7e-51 173.9 0.0 1.3 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EMD60487.1 - 3e-13 49.8 0.0 6.1e-13 48.8 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EMD60487.1 - 3.2e-06 26.6 0.1 0.00013 21.3 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EMD60487.1 - 0.00012 20.9 0.7 0.0027 16.5 0.2 2.2 2 0 0 2 2 2 1 HI0933-like protein FAD_binding_2 PF00890.24 EMD60487.1 - 0.00012 21.3 0.1 0.00022 20.4 0.1 1.6 1 1 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.27 EMD60487.1 - 0.00016 22.2 2.0 0.0006 20.3 0.4 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Prenylcys_lyase PF07156.14 EMD60487.1 - 0.00032 19.9 0.0 0.00053 19.2 0.0 1.2 1 0 0 1 1 1 1 Prenylcysteine lyase NAD_binding_9 PF13454.6 EMD60487.1 - 0.00033 20.7 1.6 0.49 10.4 0.1 2.7 3 1 0 3 3 3 2 FAD-NAD(P)-binding Thi4 PF01946.17 EMD60487.1 - 0.0012 18.2 0.2 0.0021 17.4 0.2 1.3 1 0 0 1 1 1 1 Thi4 family FAD_binding_3 PF01494.19 EMD60487.1 - 0.0018 17.6 1.1 0.0018 17.6 1.1 1.7 2 0 0 2 2 2 1 FAD binding domain AlaDh_PNT_C PF01262.21 EMD60487.1 - 0.0024 17.2 0.1 0.0039 16.5 0.1 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain DAO PF01266.24 EMD60487.1 - 0.0032 17.1 6.5 0.0032 17.1 2.4 2.6 2 1 0 2 2 2 1 FAD dependent oxidoreductase FAD_oxidored PF12831.7 EMD60487.1 - 0.023 14.0 0.1 0.08 12.3 0.0 1.9 2 0 0 2 2 2 0 FAD dependent oxidoreductase 3HCDH_N PF02737.18 EMD60487.1 - 0.097 12.6 0.4 0.22 11.4 0.4 1.6 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GIDA PF01134.22 EMD60487.1 - 0.16 11.0 2.0 0.25 10.4 0.6 1.8 2 0 0 2 2 2 0 Glucose inhibited division protein A Pyr_redox_3 PF13738.6 EMD60487.1 - 0.17 11.1 2.7 0.2 10.9 1.1 1.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.16 EMD60487.1 - 0.21 11.3 1.2 11 5.6 0.9 2.3 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA Lycopene_cycl PF05834.12 EMD60487.1 - 0.23 10.4 0.4 0.79 8.7 0.6 1.7 2 0 0 2 2 2 0 Lycopene cyclase protein PP2C PF00481.21 EMD60488.1 - 4.4e-64 216.6 0.1 1.2e-51 175.9 0.2 3.3 2 1 0 2 2 2 2 Protein phosphatase 2C GAF_2 PF13185.6 EMD60489.1 - 7e-13 49.1 0.0 1.7e-12 47.8 0.0 1.6 1 1 0 1 1 1 1 GAF domain GAF PF01590.26 EMD60489.1 - 1.5e-07 32.1 0.0 1.9e-07 31.8 0.0 1.2 1 0 0 1 1 1 1 GAF domain GAF_3 PF13492.6 EMD60489.1 - 0.075 13.4 0.0 0.39 11.1 0.0 1.9 1 1 1 2 2 2 0 GAF domain Hydrolase_4 PF12146.8 EMD60490.1 - 0.0052 16.1 0.0 0.009 15.3 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EMD60490.1 - 0.023 15.3 0.0 0.038 14.6 0.0 1.4 1 1 0 1 1 1 0 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EMD60490.1 - 0.043 13.5 0.0 0.08 12.6 0.0 1.6 1 1 0 1 1 1 0 alpha/beta hydrolase fold DSPn PF14671.6 EMD60491.1 - 3.5e-41 141.0 0.0 1e-38 133.0 0.0 2.4 2 0 0 2 2 2 2 Dual specificity protein phosphatase, N-terminal half DSPc PF00782.20 EMD60491.1 - 9.3e-16 57.9 0.0 1.7e-15 57.0 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EMD60491.1 - 1.3e-05 24.9 0.0 2.1e-05 24.2 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase CDKN3 PF05706.12 EMD60491.1 - 0.2 11.3 0.1 0.37 10.5 0.1 1.3 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) SET PF00856.28 EMD60492.1 - 0.00076 19.9 0.0 0.0019 18.6 0.0 1.6 1 1 0 1 1 1 1 SET domain Fungal_trans PF04082.18 EMD60493.1 - 4.3e-34 117.7 0.2 7.9e-34 116.9 0.2 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD60493.1 - 3e-09 36.8 11.5 6.1e-09 35.9 11.5 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain bZIP_1 PF00170.21 EMD60493.1 - 0.063 13.4 0.2 0.21 11.7 0.2 1.9 1 0 0 1 1 1 0 bZIP transcription factor KTI12 PF08433.10 EMD60494.1 - 1.1e-89 300.5 0.0 1.2e-89 300.3 0.0 1.0 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_33 PF13671.6 EMD60494.1 - 1.1e-05 25.7 0.0 2.3e-05 24.6 0.0 1.6 1 1 0 1 1 1 1 AAA domain CPT PF07931.12 EMD60494.1 - 0.026 14.4 0.0 0.046 13.6 0.0 1.4 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein AAA_22 PF13401.6 EMD60494.1 - 0.039 14.2 0.0 0.073 13.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 EMD60494.1 - 0.071 13.3 0.0 0.12 12.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain dNK PF01712.19 EMD60494.1 - 0.12 12.2 0.0 14 5.4 0.0 2.3 2 0 0 2 2 2 0 Deoxynucleoside kinase TFIIA PF03153.13 EMD60495.1 - 1 9.3 17.1 1 9.2 17.1 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PHD_3 PF13922.6 EMD60495.1 - 2.9 8.3 8.1 1.3 9.5 3.0 2.3 2 0 0 2 2 2 0 PHD domain of transcriptional enhancer, Asx DUF1754 PF08555.10 EMD60496.1 - 7.2e-15 55.6 11.7 7.2e-15 55.6 11.7 1.6 2 0 0 2 2 2 1 Eukaryotic family of unknown function (DUF1754) MSA-2c PF12238.8 EMD60496.1 - 0.34 10.9 8.4 0.42 10.6 5.5 1.9 1 1 1 2 2 2 0 Merozoite surface antigen 2c NST1 PF13945.6 EMD60496.1 - 0.36 10.9 8.3 0.47 10.5 8.3 1.1 1 0 0 1 1 1 0 Salt tolerance down-regulator CAML PF14963.6 EMD60496.1 - 0.57 10.3 6.6 0.7 10.0 6.6 1.0 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand SRP-alpha_N PF04086.13 EMD60496.1 - 2.9 7.7 13.9 3.5 7.5 13.9 1.0 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal SOBP PF15279.6 EMD60496.1 - 7.1 7.1 7.6 8.5 6.9 7.6 1.0 1 0 0 1 1 1 0 Sine oculis-binding protein NinG PF05766.12 EMD60496.1 - 9.8 6.1 9.8 0.66 9.9 4.4 1.7 1 1 1 2 2 2 0 Bacteriophage Lambda NinG protein AA_permease PF00324.21 EMD60497.1 - 2.9e-124 415.3 32.6 3.4e-124 415.0 32.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EMD60497.1 - 1.6e-38 132.7 38.3 2.4e-38 132.1 38.3 1.3 1 0 0 1 1 1 1 Amino acid permease Zn_clus PF00172.18 EMD60498.1 - 0.00013 22.0 10.2 0.00025 21.1 10.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Vfa1 PF08432.10 EMD60498.1 - 7.3 6.9 15.8 1.9 8.8 2.0 2.3 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Kinetochor_Ybp2 PF08568.10 EMD60499.1 - 5.4e-138 461.3 0.1 6.7e-138 461.0 0.1 1.0 1 0 0 1 1 1 1 Uncharacterised protein family, YAP/Alf4/glomulin LSM PF01423.22 EMD60500.1 - 3.1e-19 68.4 0.0 4e-19 68.1 0.0 1.2 1 0 0 1 1 1 1 LSM domain Cyclin_N PF00134.23 EMD60501.1 - 9.8e-45 151.4 0.3 2.2e-44 150.2 0.3 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 EMD60501.1 - 6.4e-34 116.6 0.1 1.5e-33 115.4 0.1 1.7 1 0 0 1 1 1 1 Cyclin, C-terminal domain Zn_clus PF00172.18 EMD60502.1 - 0.00041 20.4 12.1 0.00075 19.6 12.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CHZ PF09649.10 EMD60502.1 - 0.00084 18.8 0.1 0.00084 18.8 0.1 2.3 2 0 0 2 2 2 1 Histone chaperone domain CHZ Transglut_core PF01841.19 EMD60503.1 - 2.8e-12 47.1 0.0 6.1e-12 46.0 0.0 1.6 1 0 0 1 1 1 1 Transglutaminase-like superfamily DUF553 PF04473.12 EMD60503.1 - 0.013 15.0 0.0 0.17 11.4 0.0 2.4 1 1 0 1 1 1 0 Transglutaminase-like domain Gln_amidase PF15644.6 EMD60503.1 - 0.14 13.2 0.0 0.56 11.2 0.0 2.1 2 0 0 2 2 2 0 Papain fold toxin 1, glutamine deamidase YjeF_N PF03853.15 EMD60504.1 - 1.5e-40 138.9 0.0 2.7e-40 138.1 0.0 1.4 1 0 0 1 1 1 1 YjeF-related protein N-terminus FDF PF09532.10 EMD60504.1 - 2.7e-06 28.2 1.1 2.7e-06 28.2 1.1 2.3 2 0 0 2 2 2 1 FDF domain DUF1749 PF08538.10 EMD60505.1 - 2.5e-86 289.4 0.0 2.9e-86 289.3 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1749) Abhydrolase_6 PF12697.7 EMD60505.1 - 2.2e-05 25.2 0.0 3.7e-05 24.4 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EMD60505.1 - 0.00067 19.0 0.0 0.0032 16.8 0.0 2.0 1 1 0 1 1 1 1 Serine aminopeptidase, S33 DUF900 PF05990.12 EMD60505.1 - 0.014 15.0 0.0 0.032 13.8 0.0 1.6 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF900) Abhydrolase_1 PF00561.20 EMD60505.1 - 0.13 11.8 0.0 0.24 11.0 0.0 1.6 1 0 0 1 1 1 0 alpha/beta hydrolase fold SPICE PF15678.5 EMD60505.1 - 0.21 10.9 0.3 0.29 10.4 0.3 1.1 1 0 0 1 1 1 0 Centriole duplication and mitotic chromosome congression LCAT PF02450.15 EMD60505.1 - 0.21 10.7 0.0 0.29 10.3 0.0 1.2 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase F-box PF00646.33 EMD60506.1 - 0.0065 16.3 0.1 1.9 8.5 0.3 2.6 2 0 0 2 2 2 2 F-box domain PRANC PF09372.10 EMD60506.1 - 0.091 13.1 0.0 0.21 11.9 0.0 1.5 1 0 0 1 1 1 0 PRANC domain Dak1 PF02733.17 EMD60507.1 - 1.6e-106 355.7 4.7 1.6e-106 355.7 4.7 1.6 2 0 0 2 2 2 1 Dak1 domain Dak2 PF02734.17 EMD60507.1 - 2.6e-46 157.7 0.3 6.3e-46 156.4 0.3 1.7 1 0 0 1 1 1 1 DAK2 domain Ribosomal_60s PF00428.19 EMD60507.1 - 0.074 13.6 1.1 0.79 10.4 0.1 2.7 2 0 0 2 2 2 0 60s Acidic ribosomal protein DUF1442 PF07279.11 EMD60507.1 - 0.42 9.9 3.1 1.4 8.2 0.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1442) LSM PF01423.22 EMD60508.1 - 1.2e-17 63.4 0.1 1.6e-17 63.0 0.1 1.2 1 0 0 1 1 1 1 LSM domain GATA PF00320.27 EMD60509.1 - 7.2e-05 22.3 2.3 0.018 14.6 0.3 2.8 2 0 0 2 2 2 2 GATA zinc finger Zn_clus PF00172.18 EMD60509.1 - 0.65 10.2 19.3 0.29 11.3 14.8 2.6 2 1 0 2 2 2 0 Fungal Zn(2)-Cys(6) binuclear cluster domain adh_short_C2 PF13561.6 EMD60510.1 - 2.8e-52 177.6 0.2 3.9e-52 177.1 0.2 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EMD60510.1 - 8.1e-44 149.4 1.3 9.9e-44 149.1 1.3 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EMD60510.1 - 2.4e-12 47.1 0.2 3.2e-12 46.7 0.2 1.1 1 0 0 1 1 1 1 KR domain AdoHcyase_NAD PF00670.21 EMD60510.1 - 0.039 14.0 0.4 0.078 13.0 0.4 1.5 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain SurE PF01975.17 EMD60511.1 - 2.4e-52 177.5 0.0 3.2e-52 177.1 0.0 1.2 1 0 0 1 1 1 1 Survival protein SurE Med2 PF11214.8 EMD60512.1 - 0.092 12.9 3.6 0.16 12.1 3.0 1.8 1 1 0 1 1 1 0 Mediator complex subunit 2 RRM_1 PF00076.22 EMD60514.1 - 2.9e-57 190.4 0.0 7e-22 77.0 0.0 3.4 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EMD60514.1 - 7e-09 35.4 0.0 0.0021 17.9 0.0 4.1 3 1 0 3 3 3 2 Occluded RNA-recognition motif RRM_5 PF13893.6 EMD60514.1 - 3.7e-07 29.8 0.0 0.11 12.1 0.0 3.6 2 1 1 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EMD60514.1 - 0.00025 21.1 0.1 0.62 10.2 0.0 3.0 3 0 0 3 3 3 2 RNA recognition motif Nup35_RRM_2 PF14605.6 EMD60514.1 - 0.00027 20.9 0.0 14 5.7 0.0 3.5 3 0 0 3 3 3 3 Nup53/35/40-type RNA recognition motif RRM_8 PF11835.8 EMD60514.1 - 0.0023 18.1 0.0 0.36 11.1 0.0 2.4 2 0 0 2 2 2 1 RRM-like domain Cas_Cas2CT1978 PF09707.10 EMD60514.1 - 0.022 14.8 0.0 10 6.3 0.0 2.4 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_Cas2CT1978) PIF1 PF05970.14 EMD60515.1 - 3.3e-17 62.7 0.0 4.5e-17 62.3 0.0 1.2 1 0 0 1 1 1 1 PIF1-like helicase AAA_30 PF13604.6 EMD60515.1 - 2.4e-06 27.4 0.0 3.7e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 EMD60515.1 - 6e-05 22.6 0.5 0.00013 21.5 0.2 1.7 1 1 1 2 2 2 1 P-loop containing dynein motor region AAA_19 PF13245.6 EMD60515.1 - 0.00015 22.1 0.1 0.00028 21.2 0.1 1.4 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 EMD60515.1 - 0.0029 16.7 0.0 0.0043 16.2 0.0 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_16 PF13191.6 EMD60515.1 - 0.0031 17.9 0.0 0.0055 17.1 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain NACHT PF05729.12 EMD60515.1 - 0.0088 16.0 0.0 0.021 14.8 0.0 1.6 2 0 0 2 2 2 1 NACHT domain RsgA_GTPase PF03193.16 EMD60515.1 - 0.017 15.0 0.1 0.028 14.3 0.1 1.2 1 0 0 1 1 1 0 RsgA GTPase AAA_22 PF13401.6 EMD60515.1 - 0.02 15.1 0.6 0.057 13.7 0.1 1.8 2 0 0 2 2 2 0 AAA domain TrwB_AAD_bind PF10412.9 EMD60515.1 - 0.028 13.3 0.0 0.045 12.7 0.0 1.2 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain PhoH PF02562.16 EMD60515.1 - 0.033 13.6 0.0 0.057 12.9 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein DUF2075 PF09848.9 EMD60515.1 - 0.083 12.1 0.1 0.083 12.1 0.1 1.8 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) Sigma54_activat PF00158.26 EMD60515.1 - 0.084 12.6 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain RNA_helicase PF00910.22 EMD60515.1 - 0.096 13.1 0.0 0.23 11.8 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_11 PF13086.6 EMD60515.1 - 0.1 12.3 0.0 0.1 12.3 0.0 2.6 2 1 0 3 3 3 0 AAA domain UvrD-helicase PF00580.21 EMD60515.1 - 0.19 11.2 0.1 0.19 11.2 0.1 2.0 1 1 1 2 2 2 0 UvrD/REP helicase N-terminal domain Ndc1_Nup PF09531.10 EMD60515.1 - 0.42 9.2 8.1 0.7 8.5 8.1 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup PAXIP1_C PF15364.6 EMD60515.1 - 1.1 9.6 10.3 2.3 8.5 10.3 1.5 1 0 0 1 1 1 0 PAXIP1-associated-protein-1 C term PTIP binding protein ATP-synt_C PF00137.21 EMD60516.1 - 2.3e-35 120.7 34.1 5.4e-22 77.9 14.2 2.1 2 0 0 2 2 2 2 ATP synthase subunit C SF1-HH PF16275.5 EMD60517.1 - 3.4e-44 149.8 0.5 6.1e-44 149.0 0.5 1.4 1 0 0 1 1 1 1 Splicing factor 1 helix-hairpin domain Myotub-related PF06602.14 EMD60518.1 - 1.5e-146 487.8 0.0 1.9e-146 487.5 0.0 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain HD_assoc PF13286.6 EMD60518.1 - 0.16 12.5 0.0 0.34 11.5 0.0 1.5 1 0 0 1 1 1 0 Phosphohydrolase-associated domain Ribosomal_L7Ae PF01248.26 EMD60519.1 - 5.7e-27 93.3 0.0 6.6e-27 93.1 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family PELOTA_1 PF15608.6 EMD60519.1 - 0.00021 21.1 0.0 0.00029 20.7 0.0 1.2 1 0 0 1 1 1 1 PELOTA RNA binding domain RNase_P_pop3 PF08228.11 EMD60519.1 - 0.0016 18.5 0.0 0.0022 18.1 0.0 1.3 1 0 0 1 1 1 1 RNase P subunit Pop3 DUF5082 PF16888.5 EMD60519.1 - 0.071 13.4 0.6 0.52 10.6 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) NUDIX PF00293.28 EMD60520.1 - 7.8e-05 22.7 0.0 8.9e-05 22.5 0.0 1.1 1 0 0 1 1 1 1 NUDIX domain GFO_IDH_MocA PF01408.22 EMD60521.1 - 1.3e-10 42.1 0.4 9.7e-10 39.3 0.3 2.4 2 1 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold Exonuc_VII_S PF02609.16 EMD60521.1 - 0.091 12.8 0.3 5.6 7.1 0.0 2.5 2 0 0 2 2 2 0 Exonuclease VII small subunit DHDPS PF00701.22 EMD60522.1 - 3.3e-32 111.3 0.0 4e-32 111.1 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family Fungal_trans PF04082.18 EMD60523.1 - 4.6e-27 94.7 0.0 7.5e-27 94.0 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD60523.1 - 3.3e-09 36.7 11.2 6.4e-09 35.8 11.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EMD60523.1 - 0.022 13.6 0.0 0.035 12.9 0.0 1.2 1 0 0 1 1 1 0 Fungal specific transcription factor domain PIF PF05092.12 EMD60523.1 - 0.13 10.9 2.9 0.2 10.3 2.9 1.1 1 0 0 1 1 1 0 Per os infectivity GST_N_3 PF13417.6 EMD60525.1 - 3.9e-15 56.0 0.0 6.6e-15 55.3 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 EMD60525.1 - 1.7e-13 50.7 0.0 5.3e-13 49.1 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EMD60525.1 - 7.8e-12 45.3 0.0 1.5e-11 44.3 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 EMD60525.1 - 9.6e-12 45.0 0.0 1.9e-11 44.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EMD60525.1 - 1.1e-09 38.3 0.0 2.2e-09 37.4 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EMD60525.1 - 1.6e-07 31.3 0.1 3.4e-07 30.2 0.1 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain BAG PF02179.16 EMD60527.1 - 4.1e-20 72.0 0.1 6.5e-20 71.3 0.1 1.3 1 0 0 1 1 1 1 BAG domain DUF3602 PF12223.8 EMD60529.1 - 4.4e-10 40.0 11.5 0.00089 19.8 0.4 3.1 1 1 2 3 3 3 3 Protein of unknown function (DUF3602) GTP1_OBG PF01018.22 EMD60529.1 - 0.0027 17.3 6.2 0.063 12.9 0.1 3.0 1 1 2 3 3 3 2 GTP1/OBG DUF4680 PF15730.5 EMD60529.1 - 6.6 7.1 7.2 1.2 9.5 3.5 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4680) zf-C2H2 PF00096.26 EMD60530.1 - 1.1e-05 25.6 15.8 3.1e-05 24.2 2.8 3.3 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMD60530.1 - 1.1e-05 25.6 6.4 2.5e-05 24.5 3.3 2.8 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMD60530.1 - 0.0001 22.8 1.7 0.0001 22.8 1.7 3.5 3 0 0 3 3 3 1 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EMD60530.1 - 0.0032 17.4 1.3 0.0077 16.2 1.3 1.6 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EMD60530.1 - 0.0036 17.6 0.7 0.0036 17.6 0.7 1.8 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_8 PF15909.5 EMD60530.1 - 0.015 15.6 1.2 0.034 14.5 1.2 1.7 1 0 0 1 1 1 0 C2H2-type zinc ribbon FOXP-CC PF16159.5 EMD60530.1 - 0.018 15.6 7.7 0.54 10.9 0.6 3.5 1 1 2 3 3 3 0 FOXP coiled-coil domain DNA_pol_phi PF04931.13 EMD60530.1 - 0.29 9.2 4.1 0.41 8.7 4.1 1.1 1 0 0 1 1 1 0 DNA polymerase phi zf-TRAF PF02176.18 EMD60530.1 - 0.86 10.3 6.0 0.32 11.7 2.5 2.0 2 0 0 2 2 2 0 TRAF-type zinc finger IU_nuc_hydro PF01156.19 EMD60531.1 - 6.2e-81 272.3 0.0 7.7e-81 272.0 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase Ferric_reduct PF01794.19 EMD60532.1 - 3.8e-21 75.5 10.0 3.8e-21 75.5 10.0 2.2 2 0 0 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 EMD60532.1 - 7.3e-13 48.9 0.0 3.5e-05 24.0 0.0 2.2 2 0 0 2 2 2 2 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EMD60532.1 - 2.8e-08 33.8 0.0 8e-08 32.3 0.0 1.8 1 1 0 1 1 1 1 FAD-binding domain MAM33 PF02330.16 EMD60532.1 - 0.048 13.6 0.1 0.097 12.6 0.1 1.5 1 0 0 1 1 1 0 Mitochondrial glycoprotein Ribosomal_L7Ae PF01248.26 EMD60533.1 - 1.4e-25 88.9 0.9 2.7e-25 87.9 0.9 1.5 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Pkinase PF00069.25 EMD60534.1 - 2.2e-40 138.7 0.0 4.2e-40 137.8 0.0 1.4 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD60534.1 - 9.1e-31 107.1 0.0 1.3e-30 106.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EMD60534.1 - 0.017 14.0 0.4 0.12 11.2 0.0 2.2 2 0 0 2 2 2 0 Fungal protein kinase Kinase-like PF14531.6 EMD60534.1 - 0.017 14.4 0.0 0.027 13.8 0.0 1.2 1 0 0 1 1 1 0 Kinase-like APH PF01636.23 EMD60534.1 - 0.038 13.9 0.7 8 6.3 0.0 3.3 3 1 1 4 4 4 0 Phosphotransferase enzyme family LRR_6 PF13516.6 EMD60535.1 - 2.3e-17 61.5 16.4 0.085 12.9 0.1 11.6 13 0 0 13 13 13 6 Leucine Rich repeat LRR_4 PF12799.7 EMD60535.1 - 1.5e-15 57.1 7.1 0.1 13.0 0.0 7.1 5 1 1 6 6 6 6 Leucine Rich repeats (2 copies) F-box-like PF12937.7 EMD60535.1 - 6.7e-09 35.5 0.4 3.6e-08 33.2 0.0 2.5 3 0 0 3 3 3 1 F-box-like F-box PF00646.33 EMD60535.1 - 3.2e-05 23.7 0.9 0.00087 19.1 0.1 3.6 4 0 0 4 4 4 1 F-box domain DUF1699 PF08004.11 EMD60535.1 - 0.0048 16.6 0.1 0.54 9.9 0.0 3.2 3 1 0 3 3 3 1 Protein of unknown function (DUF1699) SAM_Ste50p PF09235.10 EMD60535.1 - 1.3 9.3 23.2 32 4.9 0.4 8.1 4 2 6 10 10 10 0 Ste50p, sterile alpha motif zinc_ribbon_16 PF17034.5 EMD60536.1 - 1.2e-19 70.7 6.1 3.5e-19 69.2 6.1 1.8 1 0 0 1 1 1 1 Zinc-ribbon like family Zn_ribbon_17 PF17120.5 EMD60536.1 - 0.00034 20.2 8.8 0.00099 18.7 8.8 1.8 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-rbx1 PF12678.7 EMD60536.1 - 0.01 16.1 0.4 0.01 16.1 0.4 2.2 2 0 0 2 2 2 0 RING-H2 zinc finger domain Efg1 PF10153.9 EMD60537.1 - 8.5e-34 116.3 12.5 8.5e-34 116.3 12.5 2.3 2 0 0 2 2 2 1 rRNA-processing protein Efg1 Pox_A_type_inc PF04508.12 EMD60537.1 - 0.068 13.0 0.1 0.068 13.0 0.1 3.5 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat Cytochrom_C552 PF02335.15 EMD60537.1 - 0.21 10.5 8.1 0.0086 15.0 2.6 1.4 2 0 0 2 2 2 0 Cytochrome c552 Tautomerase PF01361.21 EMD60537.1 - 0.97 9.4 3.6 0.43 10.6 0.2 2.0 2 0 0 2 2 2 0 Tautomerase enzyme Glyco_hydro_47 PF01532.20 EMD60538.1 - 7.7e-140 466.8 0.0 8.8e-140 466.6 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Adaptin_N PF01602.20 EMD60539.1 - 2.1e-144 482.0 1.9 2.5e-144 481.7 1.9 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptinC2 PF02883.20 EMD60539.1 - 3.6e-24 85.2 0.1 8.7e-24 84.0 0.1 1.7 1 0 0 1 1 1 1 Adaptin C-terminal domain Cnd1 PF12717.7 EMD60539.1 - 1.8e-07 31.4 8.1 0.00015 21.8 0.1 4.3 2 2 2 4 4 4 2 non-SMC mitotic condensation complex subunit 1 DUF3730 PF12530.8 EMD60539.1 - 0.00043 19.9 0.9 0.0019 17.8 0.2 2.3 2 1 0 2 2 2 1 Protein of unknown function (DUF3730) CLASP_N PF12348.8 EMD60539.1 - 0.0016 18.0 0.1 0.041 13.5 0.0 2.6 2 1 0 2 2 2 1 CLASP N terminal HEAT_2 PF13646.6 EMD60539.1 - 0.0028 18.0 6.2 1.1 9.6 0.0 4.5 5 0 0 5 5 5 2 HEAT repeats HEAT PF02985.22 EMD60539.1 - 0.0062 16.7 1.1 20 5.8 0.1 4.4 3 0 0 3 3 3 1 HEAT repeat Arm PF00514.23 EMD60539.1 - 0.052 13.6 0.9 1.5e+02 2.6 0.1 5.3 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat SOG2 PF10428.9 EMD60539.1 - 1.5 8.0 8.4 2.3 7.3 8.4 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein MBOAT PF03062.19 EMD60540.1 - 1.8e-34 119.6 21.8 1.8e-34 119.6 21.8 2.0 1 1 1 2 2 2 1 MBOAT, membrane-bound O-acyltransferase family MBOAT_2 PF13813.6 EMD60540.1 - 0.0039 17.4 1.5 0.011 16.0 1.5 1.7 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family Pex14_N PF04695.13 EMD60540.1 - 0.017 15.8 0.0 6.1 7.5 0.0 2.4 2 1 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF3074 PF11274.8 EMD60541.1 - 3e-60 203.3 2.4 8.8e-60 201.8 0.0 2.4 2 1 0 2 2 2 1 Protein of unknown function (DUF3074) START PF01852.19 EMD60541.1 - 1.8e-05 24.2 0.4 3.8e-05 23.2 0.0 1.7 2 0 0 2 2 2 1 START domain DUF4407 PF14362.6 EMD60541.1 - 0.76 9.1 17.6 1.2 8.4 17.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Exonuc_VII_L PF02601.15 EMD60541.1 - 2.2 7.7 19.4 3.5 7.1 19.4 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Cupin_8 PF13621.6 EMD60541.1 - 8.1 6.1 9.2 12 5.5 8.3 1.7 1 1 0 1 1 1 0 Cupin-like domain FSH1 PF03959.13 EMD60542.1 - 9.8e-17 61.3 0.0 1.3e-16 60.9 0.0 1.2 1 0 0 1 1 1 1 Serine hydrolase (FSH1) CoA_transf_3 PF02515.17 EMD60544.1 - 2.5e-39 135.4 0.0 5.3e-39 134.4 0.0 1.6 2 0 0 2 2 2 1 CoA-transferase family III Spidroin_N PF16763.5 EMD60544.1 - 0.11 12.6 0.0 0.27 11.3 0.0 1.6 1 0 0 1 1 1 0 Major ampullate spidroin 1, spider silk protein 1, N-term Fungal_trans PF04082.18 EMD60545.1 - 1.1e-24 86.9 0.2 2e-24 86.0 0.2 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD60545.1 - 1.8e-06 27.9 13.5 3.3e-06 27.1 13.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TFIIS_C PF01096.18 EMD60546.1 - 2e-19 69.2 5.5 2e-19 69.2 5.5 2.9 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.16 EMD60546.1 - 2.7e-05 23.9 10.1 0.04 13.8 0.0 3.6 4 0 0 4 4 4 2 RNA polymerases M/15 Kd subunit Acetone_carb_G PF08882.11 EMD60546.1 - 0.0077 16.4 0.1 0.0077 16.4 0.1 2.3 1 1 0 2 2 2 1 Acetone carboxylase gamma subunit zf-Mss51 PF13824.6 EMD60546.1 - 0.42 10.7 4.1 1.4 9.1 0.1 2.4 2 0 0 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 zf-H2C2_2 PF13465.6 EMD60546.1 - 1.4 9.5 14.1 1.3 9.6 0.2 4.0 4 0 0 4 4 4 0 Zinc-finger double domain Ank_5 PF13857.6 EMD60547.1 - 1.2e-10 41.4 0.5 8.3e-06 26.0 0.1 4.0 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMD60547.1 - 1.8e-09 37.0 0.1 0.0011 19.3 0.0 3.8 3 1 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 EMD60547.1 - 7.9e-08 32.4 0.1 0.03 14.8 0.0 3.2 3 0 0 3 3 3 2 Ankyrin repeat Ank_2 PF12796.7 EMD60547.1 - 1.4e-07 31.9 0.1 5.4e-07 30.1 0.1 2.0 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMD60547.1 - 4.2e-07 30.4 0.0 2.1e-05 25.0 0.0 2.9 3 0 0 3 3 3 1 Ankyrin repeats (many copies) SF3b10 PF07189.11 EMD60548.1 - 5.5e-35 119.3 0.0 6.1e-35 119.2 0.0 1.0 1 0 0 1 1 1 1 Splicing factor 3B subunit 10 (SF3b10) Vinculin PF01044.19 EMD60549.1 - 0.0031 15.8 0.0 0.0035 15.6 0.0 1.0 1 0 0 1 1 1 1 Vinculin family Co_AT_N PF12557.8 EMD60549.1 - 0.49 10.4 8.7 0.079 12.9 4.6 1.8 2 0 0 2 2 2 0 Cob(I)alamin adenosyltransferase N terminal Abhydrolase_6 PF12697.7 EMD60550.1 - 1.2e-12 48.9 2.7 2.9e-11 44.4 2.7 2.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EMD60550.1 - 1.7e-12 47.5 0.2 5.8e-08 32.7 0.2 2.3 2 0 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EMD60550.1 - 4.1e-05 23.0 0.1 0.00092 18.5 0.1 2.1 2 0 0 2 2 2 1 Serine aminopeptidase, S33 EHN PF06441.12 EMD60550.1 - 0.054 13.9 0.0 0.17 12.3 0.0 1.8 2 0 0 2 2 2 0 Epoxide hydrolase N terminus Homeodomain PF00046.29 EMD60551.1 - 6.4e-11 41.9 0.1 1.7e-10 40.6 0.1 1.7 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EMD60551.1 - 0.00014 21.7 0.2 0.00014 21.7 0.2 2.6 3 0 0 3 3 3 1 Homeobox KN domain zf-C2H2_jaz PF12171.8 EMD60551.1 - 0.0054 17.0 13.4 0.013 15.8 0.2 4.1 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 EMD60551.1 - 0.012 16.4 1.2 0.012 16.4 1.2 7.9 8 0 0 8 8 8 0 C2H2-type zinc finger zf-C2H2 PF00096.26 EMD60551.1 - 0.031 14.7 0.9 0.031 14.7 0.9 7.2 8 0 0 8 8 8 0 Zinc finger, C2H2 type UTP15_C PF09384.10 EMD60552.1 - 1.3e-46 158.0 0.2 2.3e-46 157.2 0.2 1.4 1 0 0 1 1 1 1 UTP15 C terminal WD40 PF00400.32 EMD60552.1 - 2.9e-19 69.0 1.1 0.002 18.9 0.2 6.1 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD60552.1 - 1.4e-08 34.9 0.6 0.0066 16.7 0.1 4.4 1 1 5 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain PAS_2 PF08446.11 EMD60552.1 - 0.061 14.0 0.1 22 5.8 0.0 2.5 2 0 0 2 2 2 0 PAS fold Ribosomal_L22 PF00237.19 EMD60553.1 - 3.9e-23 81.6 0.0 3.9e-22 78.4 0.0 2.2 1 1 0 1 1 1 1 Ribosomal protein L22p/L17e DUF643 PF04867.12 EMD60553.1 - 0.51 11.0 3.9 0.45 11.2 0.8 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF643) RRM_1 PF00076.22 EMD60554.1 - 1.3e-46 156.3 0.4 1e-15 57.3 0.1 4.5 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EMD60554.1 - 1.2e-31 108.4 0.0 3e-25 87.9 0.0 3.3 3 0 0 3 3 3 2 Occluded RNA-recognition motif RRM_7 PF16367.5 EMD60554.1 - 0.00033 20.7 0.0 0.0099 16.0 0.0 3.3 3 0 0 3 3 3 1 RNA recognition motif Phage_Treg PF04761.12 EMD60554.1 - 0.027 14.6 0.0 0.07 13.2 0.0 1.7 1 0 0 1 1 1 0 Lactococcus bacteriophage putative transcription regulator Lsm_interact PF05391.11 EMD60554.1 - 0.034 13.6 0.2 0.075 12.6 0.2 1.6 1 0 0 1 1 1 0 Lsm interaction motif TPR_14 PF13428.6 EMD60554.1 - 0.035 14.9 0.3 8.3 7.5 0.0 4.1 3 0 0 3 3 3 0 Tetratricopeptide repeat RHH_5 PF07878.11 EMD60555.1 - 0.14 12.1 0.4 0.58 10.1 0.2 2.2 1 1 0 1 1 1 0 CopG-like RHH_1 or ribbon-helix-helix domain, RHH_5 PID_2 PF14719.6 EMD60556.1 - 0.071 13.0 0.0 0.08 12.8 0.0 1.1 1 0 0 1 1 1 0 Phosphotyrosine interaction domain (PTB/PID) Ferric_reduct PF01794.19 EMD60557.1 - 2e-24 86.1 7.0 2e-24 86.1 7.0 2.0 2 0 0 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 EMD60557.1 - 7.7e-18 65.1 0.0 6.5e-11 42.6 0.0 2.2 1 1 1 2 2 2 2 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EMD60557.1 - 9.1e-13 48.3 0.0 1.2e-11 44.6 0.0 2.2 1 1 0 1 1 1 1 FAD-binding domain NUDIX PF00293.28 EMD60559.1 - 0.00013 22.0 0.1 0.00028 20.9 0.1 1.6 2 0 0 2 2 2 1 NUDIX domain 3HCDH_N PF02737.18 EMD60560.1 - 1.5e-48 165.1 0.0 3.1e-48 164.0 0.0 1.6 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 EMD60560.1 - 1.6e-13 51.1 0.0 4.7e-13 49.6 0.0 1.8 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain UDPG_MGDP_dh_N PF03721.14 EMD60560.1 - 2.9e-06 27.0 0.0 8.8e-06 25.4 0.0 1.8 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_Gly3P_dh_N PF01210.23 EMD60560.1 - 8.2e-06 25.9 0.0 1.7e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus SGL PF08450.12 EMD60560.1 - 0.00026 20.7 0.0 0.17 11.5 0.0 2.9 2 1 0 2 2 2 2 SMP-30/Gluconolactonase/LRE-like region DUF5074 PF16819.5 EMD60560.1 - 0.00028 20.9 0.1 0.036 14.1 0.0 2.7 1 1 1 2 2 2 1 Domain of unknown function (DUF5074) ApbA PF02558.16 EMD60560.1 - 0.0024 17.6 0.0 0.017 14.8 0.0 2.3 2 0 0 2 2 2 1 Ketopantoate reductase PanE/ApbA AlaDh_PNT_C PF01262.21 EMD60560.1 - 0.0027 17.1 0.0 0.0046 16.3 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.19 EMD60560.1 - 0.0039 16.6 0.0 0.015 14.7 0.0 1.9 1 1 1 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_2 PF03446.15 EMD60560.1 - 0.011 15.9 0.0 0.034 14.3 0.0 1.9 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Ldl_recept_b PF00058.17 EMD60560.1 - 0.012 16.1 4.4 3.8 8.1 0.1 5.1 5 0 0 5 5 5 0 Low-density lipoprotein receptor repeat class B Pyr_redox PF00070.27 EMD60560.1 - 0.015 15.8 0.0 0.046 14.3 0.0 1.9 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Lactonase PF10282.9 EMD60560.1 - 0.024 13.9 0.0 3.2 6.9 0.0 3.0 3 0 0 3 3 3 0 Lactonase, 7-bladed beta-propeller NAD_binding_7 PF13241.6 EMD60560.1 - 0.093 13.2 0.0 0.31 11.5 0.0 1.9 1 0 0 1 1 1 0 Putative NAD(P)-binding Ldh_1_N PF00056.23 EMD60560.1 - 0.13 12.4 0.0 0.27 11.3 0.0 1.5 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain CoA_transf_3 PF02515.17 EMD60561.1 - 4e-40 138.1 0.6 8.5e-40 137.0 0.3 1.6 2 0 0 2 2 2 1 CoA-transferase family III Acetyltransf_1 PF00583.25 EMD60562.1 - 0.016 15.4 0.0 0.02 15.1 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Peptidase_M14 PF00246.24 EMD60563.1 - 1.9e-65 221.5 0.0 5.3e-65 220.1 0.0 1.6 2 0 0 2 2 2 1 Zinc carboxypeptidase GTP_EFTU PF00009.27 EMD60564.1 - 4.8e-55 186.1 0.0 8.6e-55 185.3 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EMD60564.1 - 5.8e-42 142.5 0.0 1.3e-41 141.4 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EMD60564.1 - 1.1e-13 51.4 2.7 1.1e-13 51.4 2.7 2.3 3 0 0 3 3 3 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EMD60564.1 - 0.00056 20.0 0.1 0.015 15.4 0.1 2.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase Pkinase PF00069.25 EMD60566.1 - 1.8e-57 194.7 0.1 2.5e-57 194.3 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD60566.1 - 2.8e-21 76.0 0.0 4.4e-21 75.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMD60566.1 - 1.4e-06 27.8 0.0 2.2e-06 27.2 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EMD60566.1 - 2.4e-05 23.5 0.1 3.9e-05 22.8 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EMD60566.1 - 0.00096 19.1 0.2 0.32 10.9 0.0 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family RIO1 PF01163.22 EMD60566.1 - 0.002 17.8 0.1 0.0048 16.5 0.1 1.6 1 0 0 1 1 1 1 RIO1 family Pkinase_fungal PF17667.1 EMD60566.1 - 0.011 14.5 0.0 0.021 13.6 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase Peptidase_M41 PF01434.18 EMD60567.1 - 9.2e-68 227.9 0.0 1.9e-67 226.8 0.0 1.6 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 EMD60567.1 - 1.1e-41 142.4 0.1 3.3e-41 140.8 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EMD60567.1 - 1.1e-11 44.4 0.2 3.3e-11 42.8 0.2 1.8 1 0 0 1 1 1 1 AAA+ lid domain FtsH_ext PF06480.15 EMD60567.1 - 1.2e-11 44.9 0.1 3.6e-11 43.4 0.0 1.8 2 0 0 2 2 2 1 FtsH Extracellular AAA_5 PF07728.14 EMD60567.1 - 0.0056 16.7 0.0 0.019 15.0 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EMD60567.1 - 0.016 15.6 0.4 1.6 9.1 0.4 2.8 1 1 0 2 2 2 0 AAA ATPase domain TIP49 PF06068.13 EMD60567.1 - 0.018 14.3 0.0 0.032 13.5 0.0 1.4 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_22 PF13401.6 EMD60567.1 - 0.038 14.3 0.2 7.2 6.9 0.1 3.0 3 0 0 3 3 3 0 AAA domain RuvB_N PF05496.12 EMD60567.1 - 0.073 12.8 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 EMD60567.1 - 0.1 12.7 0.1 0.51 10.4 0.0 2.2 3 0 0 3 3 3 0 AAA domain (Cdc48 subfamily) RRF PF01765.19 EMD60567.1 - 0.14 12.2 1.0 0.41 10.6 0.4 2.1 2 0 0 2 2 2 0 Ribosome recycling factor APH PF01636.23 EMD60568.1 - 5.8e-11 42.8 0.1 1.1e-10 41.9 0.1 1.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EMD60568.1 - 0.00078 19.1 0.0 0.0013 18.4 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase EcKinase PF02958.20 EMD60568.1 - 0.0012 18.3 0.0 0.0023 17.3 0.0 1.4 2 0 0 2 2 2 1 Ecdysteroid kinase DUF1679 PF07914.11 EMD60568.1 - 0.0043 16.0 0.0 0.006 15.5 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1679) UL97 PF06734.12 EMD60568.1 - 0.22 11.4 0.0 0.34 10.8 0.0 1.2 1 0 0 1 1 1 0 UL97 UcrQ PF02939.16 EMD60570.1 - 6.2e-30 103.0 0.2 7.6e-30 102.7 0.2 1.1 1 0 0 1 1 1 1 UcrQ family CFEM PF05730.11 EMD60571.1 - 9.4e-11 41.7 2.3 1.8e-10 40.7 2.3 1.4 1 0 0 1 1 1 1 CFEM domain zinc-ribbons_6 PF07191.12 EMD60571.1 - 0.015 15.2 2.1 0.032 14.2 2.1 1.5 1 0 0 1 1 1 0 zinc-ribbons DUF1793 PF08760.11 EMD60574.1 - 5.8e-70 235.1 0.4 1.4e-69 233.8 0.2 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF1793) DUF4965 PF16335.5 EMD60574.1 - 1.9e-62 210.0 0.8 1.3e-49 168.2 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF4965) DUF5127 PF17168.4 EMD60574.1 - 1.1e-42 146.4 0.2 1.8e-42 145.7 0.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF5127) DUF4964 PF16334.5 EMD60574.1 - 0.0071 15.9 0.1 0.028 14.0 0.1 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4964) Methyltransf_23 PF13489.6 EMD60576.1 - 1.4e-09 38.0 0.0 2.2e-09 37.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMD60576.1 - 4.9e-09 36.7 0.0 1e-08 35.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMD60576.1 - 1.5e-06 28.9 0.0 3.1e-06 27.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMD60576.1 - 3.2e-05 23.7 0.0 6.4e-05 22.8 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMD60576.1 - 3.6e-05 24.4 0.0 8.7e-05 23.2 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EMD60576.1 - 0.035 13.4 0.0 0.075 12.4 0.0 1.6 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family Dynactin_p62 PF05502.13 EMD60577.1 - 6e-199 661.7 0.1 7.1e-199 661.5 0.1 1.0 1 0 0 1 1 1 1 Dynactin p62 family Mu-like_Com PF10122.9 EMD60577.1 - 0.12 11.9 3.9 1.5 8.3 0.6 3.0 2 0 0 2 2 2 0 Mu-like prophage protein Com FAD_binding_7 PF03441.14 EMD60578.1 - 2e-74 249.5 0.2 3.1e-74 248.8 0.2 1.3 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.18 EMD60578.1 - 5e-38 130.7 0.0 9.4e-38 129.8 0.0 1.4 1 0 0 1 1 1 1 DNA photolyase NAM-associated PF14303.6 EMD60578.1 - 0.72 10.6 5.7 2.1 9.1 5.7 1.7 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain Glyco_transf_8 PF01501.20 EMD60580.1 - 1.2e-26 93.9 0.5 7.9e-26 91.1 0.5 1.9 1 1 0 1 1 1 1 Glycosyl transferase family 8 Nucleotid_trans PF03407.16 EMD60580.1 - 0.003 17.6 0.0 0.0048 16.9 0.0 1.3 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase Mannosyl_trans3 PF11051.8 EMD60580.1 - 0.007 15.8 0.0 0.011 15.2 0.0 1.2 1 0 0 1 1 1 1 Mannosyltransferase putative Peptidase_M20 PF01546.28 EMD60581.1 - 2.1e-33 115.8 0.0 2.7e-33 115.4 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EMD60581.1 - 1e-12 47.9 0.0 1.8e-12 47.1 0.0 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain MRP-L20 PF12824.7 EMD60582.1 - 2.9e-51 173.9 5.8 3.5e-51 173.6 5.8 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein subunit L20 DUF1179 PF06678.11 EMD60582.1 - 0.88 9.6 3.3 1.5 8.9 2.8 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1179) Mitochondr_Som1 PF11093.8 EMD60583.1 - 1.4e-24 85.9 0.0 1.6e-24 85.7 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial export protein Som1 TAF8_C PF10406.9 EMD60584.1 - 2e-20 73.1 0.5 2e-20 73.1 0.5 2.3 3 0 0 3 3 3 1 Transcription factor TFIID complex subunit 8 C-term Bromo_TP PF07524.13 EMD60584.1 - 5.7e-07 29.5 0.0 9.3e-07 28.8 0.0 1.3 1 0 0 1 1 1 1 Bromodomain associated COX6C PF02937.15 EMD60585.1 - 0.041 14.0 0.0 0.045 13.9 0.0 1.0 1 0 0 1 1 1 0 Cytochrome c oxidase subunit VIc KIX_2 PF16987.5 EMD60586.1 - 1.6e-07 31.2 0.4 1.6e-07 31.2 0.4 4.5 4 0 0 4 4 4 1 KIX domain UPF0242 PF06785.11 EMD60588.1 - 0.44 10.6 0.8 0.52 10.4 0.4 1.3 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus WD40 PF00400.32 EMD60589.1 - 2.2e-25 88.4 10.5 1e-05 26.2 0.1 6.8 6 0 0 6 6 6 5 WD domain, G-beta repeat F-box-like PF12937.7 EMD60589.1 - 1e-09 38.1 0.2 2.2e-09 37.0 0.2 1.6 1 0 0 1 1 1 1 F-box-like Nup160 PF11715.8 EMD60589.1 - 2.9e-07 29.5 0.1 0.023 13.3 0.0 3.4 2 1 1 3 3 3 3 Nucleoporin Nup120/160 F-box PF00646.33 EMD60589.1 - 6.4e-06 25.9 0.0 1.3e-05 25.0 0.0 1.5 1 0 0 1 1 1 1 F-box domain PQQ_2 PF13360.6 EMD60589.1 - 0.007 16.0 0.5 0.026 14.1 0.5 2.0 1 1 0 1 1 1 1 PQQ-like domain PQQ_3 PF13570.6 EMD60589.1 - 0.016 15.7 0.4 2.5 8.7 0.0 3.3 2 0 0 2 2 2 0 PQQ-like domain Abhydrolase_6 PF12697.7 EMD60592.1 - 6e-05 23.7 0.2 0.00011 22.8 0.2 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family PGAP1 PF07819.13 EMD60592.1 - 9.9e-05 22.2 0.1 0.00089 19.0 0.0 2.2 1 1 1 2 2 2 1 PGAP1-like protein Hydrolase_4 PF12146.8 EMD60592.1 - 0.0019 17.5 0.0 0.0037 16.5 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 UPF0227 PF05728.12 EMD60592.1 - 0.0024 17.8 0.0 0.0024 17.8 0.0 2.0 2 0 0 2 2 1 1 Uncharacterised protein family (UPF0227) Abhydrolase_1 PF00561.20 EMD60592.1 - 0.0072 16.0 0.0 0.021 14.4 0.0 1.8 1 0 0 1 1 1 1 alpha/beta hydrolase fold Macoilin PF09726.9 EMD60592.1 - 0.0082 14.8 18.7 0.012 14.3 18.7 1.1 1 0 0 1 1 1 1 Macoilin family CNDH2_C PF16858.5 EMD60592.1 - 0.019 14.9 17.3 0.036 14.0 17.3 1.4 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term Lipase_3 PF01764.25 EMD60592.1 - 0.062 13.2 0.0 0.16 11.8 0.0 1.7 1 0 0 1 1 1 0 Lipase (class 3) LIDHydrolase PF10230.9 EMD60592.1 - 0.084 12.4 0.0 0.16 11.5 0.0 1.4 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase SHNi-TPR PF10516.9 EMD60592.1 - 0.11 12.0 0.1 0.32 10.5 0.1 1.8 1 0 0 1 1 1 0 SHNi-TPR DUF2151 PF10221.9 EMD60592.1 - 0.3 9.6 12.7 0.43 9.1 12.7 1.1 1 0 0 1 1 1 0 Cell cycle and development regulator Borrelia_P83 PF05262.11 EMD60592.1 - 0.87 8.0 24.4 1.3 7.5 24.4 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein MCM_bind PF09739.9 EMD60592.1 - 0.92 7.9 14.9 2 6.8 14.0 1.8 2 0 0 2 2 2 0 Mini-chromosome maintenance replisome factor RR_TM4-6 PF06459.12 EMD60592.1 - 1.3 8.8 24.6 2.5 7.9 24.6 1.5 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 TFIIA PF03153.13 EMD60592.1 - 1.4 8.8 26.8 1.9 8.4 26.8 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit TEX19 PF15553.6 EMD60592.1 - 1.5 8.8 4.9 3.1 7.7 4.9 1.5 1 0 0 1 1 1 0 Testis-expressed protein 19 AAA_11 PF13086.6 EMD60592.1 - 2 8.1 16.9 5.1 6.8 16.9 1.7 1 0 0 1 1 1 0 AAA domain Atg14 PF10186.9 EMD60592.1 - 2.6 7.0 19.3 4.4 6.3 19.3 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 LicD PF04991.13 EMD60592.1 - 3.5 7.7 7.8 6.3 6.9 7.8 1.4 1 0 0 1 1 1 0 LicD family Asp-B-Hydro_N PF05279.11 EMD60592.1 - 3.5 7.6 24.8 6.1 6.8 24.8 1.3 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region DUF3584 PF12128.8 EMD60592.1 - 3.5 5.0 29.6 5.4 4.4 29.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) BATS PF06968.13 EMD60594.1 - 7e-23 80.6 0.0 1.5e-22 79.5 0.0 1.6 1 0 0 1 1 1 1 Biotin and Thiamin Synthesis associated domain Radical_SAM PF04055.21 EMD60594.1 - 5.9e-15 56.0 0.2 1.1e-13 51.9 0.1 2.1 2 0 0 2 2 2 1 Radical SAM superfamily Aminotran_1_2 PF00155.21 EMD60595.1 - 4.9e-40 137.8 0.0 5.7e-40 137.6 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EMD60595.1 - 2e-05 23.3 0.0 3e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 EMD60595.1 - 7.2e-05 21.9 0.0 0.019 14.0 0.0 2.1 2 0 0 2 2 2 2 Aminotransferase class-V Beta_elim_lyase PF01212.21 EMD60595.1 - 0.073 12.3 0.1 0.16 11.2 0.0 1.6 2 0 0 2 2 2 0 Beta-eliminating lyase OKR_DC_1 PF01276.20 EMD60595.1 - 0.14 10.9 0.1 0.43 9.3 0.1 1.7 1 1 0 1 1 1 0 Orn/Lys/Arg decarboxylase, major domain Aminotran_3 PF00202.21 EMD60596.1 - 1.5e-39 135.8 0.0 2.8e-18 65.8 0.0 3.2 3 0 0 3 3 3 3 Aminotransferase class-III AAA_26 PF13500.6 EMD60596.1 - 3.4e-15 56.4 0.0 7.8e-15 55.2 0.0 1.6 1 1 0 1 1 1 1 AAA domain LAL_C2 PF18603.1 EMD60596.1 - 0.035 14.2 0.1 0.091 12.9 0.1 1.7 1 0 0 1 1 1 0 L-amino acid ligase C-terminal domain 2 RNA_helicase PF00910.22 EMD60596.1 - 0.07 13.5 0.3 1.5 9.3 0.0 3.0 4 0 0 4 4 4 0 RNA helicase ADH_zinc_N PF00107.26 EMD60598.1 - 2.7e-13 50.0 0.0 9.2e-13 48.3 0.0 1.9 2 1 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EMD60598.1 - 2.2e-11 43.6 0.0 4.2e-11 42.7 0.0 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 EMD60598.1 - 0.065 14.3 0.0 0.13 13.3 0.0 1.6 1 1 0 1 1 1 0 Zinc-binding dehydrogenase DUF2235 PF09994.9 EMD60601.1 - 4.1e-88 295.5 0.0 5.4e-88 295.1 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) PLDc_2 PF13091.6 EMD60602.1 - 3.3e-21 75.6 0.0 2.3e-14 53.4 0.0 2.9 2 2 0 2 2 2 2 PLD-like domain PLDc PF00614.22 EMD60602.1 - 0.00028 20.9 0.1 0.09 13.0 0.0 2.9 3 0 0 3 3 3 2 Phospholipase D Active site motif Regulator_TrmB PF11495.8 EMD60602.1 - 0.053 12.7 0.2 1.7 7.8 0.0 3.0 4 0 0 4 4 4 0 Archaeal transcriptional regulator TrmB Stb3 PF10330.9 EMD60604.1 - 6.8e-30 103.0 0.0 1.6e-29 101.8 0.0 1.6 1 0 0 1 1 1 1 Putative Sin3 binding protein Topoisom_bac PF01131.20 EMD60606.1 - 4.1e-103 345.6 0.0 6.6e-96 321.8 0.0 2.1 2 0 0 2 2 2 2 DNA topoisomerase Toprim PF01751.22 EMD60606.1 - 2.6e-18 66.2 0.0 7e-18 64.8 0.0 1.8 1 0 0 1 1 1 1 Toprim domain DUF1295 PF06966.12 EMD60607.1 - 1.2e-31 110.1 9.6 1.4e-31 109.8 9.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) ICMT PF04140.14 EMD60607.1 - 0.075 13.5 0.8 0.38 11.2 0.0 2.5 2 0 0 2 2 2 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family ECR1_N PF14382.6 EMD60608.1 - 2.5e-15 56.0 0.8 5.6e-15 54.8 0.8 1.6 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region KH_6 PF15985.5 EMD60608.1 - 0.00025 21.3 0.1 0.0019 18.5 0.1 2.2 2 0 0 2 2 2 1 KH domain TMEM234 PF10639.9 EMD60610.1 - 4.1e-41 139.6 0.9 4.8e-41 139.4 0.9 1.0 1 0 0 1 1 1 1 Putative transmembrane family 234 EamA PF00892.20 EMD60610.1 - 0.00016 21.8 10.3 0.21 11.7 6.7 2.7 2 1 0 2 2 2 2 EamA-like transporter family DUF5493 PF17597.2 EMD60610.1 - 1 9.7 5.9 4.6 7.6 2.7 2.5 2 1 1 3 3 3 0 Family of unknown function (DUF5493) PhyH PF05721.13 EMD60611.1 - 7e-55 186.5 0.0 9.1e-55 186.2 0.0 1.1 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) ketoacyl-synt PF00109.26 EMD60612.1 - 3.2e-72 243.1 0.0 5.8e-72 242.3 0.0 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.10 EMD60612.1 - 3.8e-64 215.9 0.2 6.7e-61 205.3 0.2 3.5 3 0 0 3 3 3 2 KR domain PS-DH PF14765.6 EMD60612.1 - 4.6e-52 177.1 0.0 8e-52 176.3 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 EMD60612.1 - 2.4e-48 165.3 0.1 4e-48 164.5 0.1 1.4 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EMD60612.1 - 4e-35 120.4 0.0 9.3e-35 119.2 0.0 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 EMD60612.1 - 2.6e-12 47.2 0.0 6.6e-08 33.0 0.0 3.0 2 0 0 2 2 2 2 Ketoacyl-synthetase C-terminal extension adh_short PF00106.25 EMD60612.1 - 2.4e-11 43.5 0.0 3.9e-09 36.3 0.0 3.1 3 0 0 3 3 3 1 short chain dehydrogenase ADH_zinc_N_2 PF13602.6 EMD60612.1 - 2.9e-07 31.6 0.0 1.1e-06 29.7 0.0 2.1 1 0 0 1 1 1 1 Zinc-binding dehydrogenase adh_short_C2 PF13561.6 EMD60612.1 - 3.8e-06 26.6 0.0 1e-05 25.3 0.0 1.7 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase PP-binding PF00550.25 EMD60612.1 - 1.2e-05 25.6 0.0 2.8e-05 24.4 0.0 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site ADH_N PF08240.12 EMD60612.1 - 5.4e-05 23.0 0.0 0.00017 21.4 0.0 1.9 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Thiolase_N PF00108.23 EMD60612.1 - 0.0012 18.3 0.0 0.0048 16.3 0.0 1.9 2 0 0 2 2 2 1 Thiolase, N-terminal domain DUF3180 PF11377.8 EMD60612.1 - 0.021 14.9 3.3 0.031 14.4 0.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3180) ACP_syn_III PF08545.10 EMD60612.1 - 0.055 13.3 1.3 0.15 12.0 1.3 1.7 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III MFS_1 PF07690.16 EMD60613.1 - 1.8e-36 125.8 18.3 1.8e-36 125.8 18.3 1.3 2 0 0 2 2 2 1 Major Facilitator Superfamily MFS_4 PF06779.14 EMD60613.1 - 6.5e-07 29.0 2.7 1.2e-06 28.1 2.7 1.4 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB Sugar_tr PF00083.24 EMD60613.1 - 7.8e-06 25.0 11.0 1.8e-05 23.8 10.9 1.9 1 1 0 1 1 1 1 Sugar (and other) transporter HCMV_UL124 PF17609.2 EMD60613.1 - 0.1 12.8 0.0 0.18 12.0 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function LapA_dom PF06305.11 EMD60613.1 - 0.22 11.4 0.8 1 9.2 0.0 2.7 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain Mito_carr PF00153.27 EMD60614.1 - 1.3e-50 169.2 12.2 2.6e-17 62.5 0.2 3.4 4 0 0 4 4 4 3 Mitochondrial carrier protein Ank_2 PF12796.7 EMD60615.1 - 2.2e-28 98.7 4.3 5.4e-12 46.1 0.3 2.7 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EMD60615.1 - 3.7e-19 66.8 1.2 1.1e-05 25.4 0.0 4.3 4 0 0 4 4 4 3 Ankyrin repeat Ank PF00023.30 EMD60615.1 - 1.4e-18 66.4 3.7 7.6e-05 23.0 0.0 4.2 4 0 0 4 4 4 4 Ankyrin repeat Ank_4 PF13637.6 EMD60615.1 - 4.9e-18 65.2 3.8 1.2e-10 41.7 0.2 3.5 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EMD60615.1 - 2.1e-11 43.8 5.0 0.00019 21.7 0.0 4.0 2 1 2 4 4 4 3 Ankyrin repeats (many copies) peroxidase PF00141.23 EMD60616.1 - 3.4e-18 66.2 0.3 5.6e-18 65.5 0.3 1.2 1 0 0 1 1 1 1 Peroxidase Helo_like_N PF17111.5 EMD60617.1 - 3.1e-06 26.7 0.3 3.9e-06 26.4 0.3 1.1 1 0 0 1 1 1 1 Fungal N-terminal domain of STAND proteins SesA PF17107.5 EMD60617.1 - 0.024 14.8 0.9 0.03 14.5 0.9 1.4 1 1 0 1 1 1 0 N-terminal domain on NACHT_NTPase and P-loop NTPases tRNA-synt_1f PF01921.18 EMD60617.1 - 0.031 13.2 0.0 0.037 12.9 0.0 1.1 1 0 0 1 1 1 0 tRNA synthetases class I (K) HGD-D PF06050.13 EMD60617.1 - 0.12 12.1 0.1 0.14 11.9 0.1 1.1 1 0 0 1 1 1 0 2-hydroxyglutaryl-CoA dehydratase, D-component Ribosomal_L24e PF01246.20 EMD60620.1 - 1.7e-32 111.5 5.8 4.2e-32 110.2 5.8 1.7 1 0 0 1 1 1 1 Ribosomal protein L24e Gar1 PF04410.14 EMD60620.1 - 0.043 13.6 0.4 0.06 13.1 0.4 1.2 1 0 0 1 1 1 0 Gar1/Naf1 RNA binding region DUF2175 PF09943.9 EMD60620.1 - 4.3 7.7 6.7 9.9 6.5 0.4 2.5 2 1 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2175) Pam16 PF03656.13 EMD60621.1 - 6.9e-06 26.1 0.0 7.7e-06 25.9 0.0 1.1 1 0 0 1 1 1 1 Pam16 DnaJ PF00226.31 EMD60621.1 - 0.00028 20.9 0.0 0.00044 20.3 0.0 1.3 1 0 0 1 1 1 1 DnaJ domain Glyco_hydro_61 PF03443.14 EMD60622.1 - 1.2e-53 182.2 0.1 1.4e-53 181.9 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 rhaM PF05336.13 EMD60624.1 - 4.7e-38 129.6 0.2 5.3e-38 129.4 0.2 1.0 1 0 0 1 1 1 1 L-rhamnose mutarotase CLU PF13236.6 EMD60625.1 - 6.2e-73 245.3 0.0 1.1e-72 244.5 0.0 1.4 1 0 0 1 1 1 1 Clustered mitochondria eIF3_p135 PF12807.7 EMD60625.1 - 3.2e-50 170.6 0.3 1.8e-49 168.1 0.0 2.4 2 0 0 2 2 2 1 Translation initiation factor eIF3 subunit 135 TPR_12 PF13424.6 EMD60625.1 - 1.1e-30 105.7 16.9 2.3e-15 56.7 0.4 4.8 1 1 4 5 5 5 4 Tetratricopeptide repeat TPR_10 PF13374.6 EMD60625.1 - 1.1e-26 91.9 2.6 7.7e-08 32.0 0.0 5.7 5 0 0 5 5 5 3 Tetratricopeptide repeat CLU_N PF15044.6 EMD60625.1 - 1.1e-24 86.6 0.4 3.2e-24 85.1 0.4 1.9 1 0 0 1 1 1 1 Mitochondrial function, CLU-N-term TPR_2 PF07719.17 EMD60625.1 - 2.4e-05 24.1 3.1 3.6 7.9 0.0 4.2 3 0 0 3 3 3 3 Tetratricopeptide repeat DUF727 PF05303.12 EMD60625.1 - 5e-05 23.3 0.0 0.00014 21.9 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF727) TPR_8 PF13181.6 EMD60625.1 - 0.00089 19.3 4.2 1.8 9.0 0.2 4.3 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 EMD60625.1 - 0.009 16.0 0.5 12 6.2 0.0 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 EMD60625.1 - 0.017 14.9 1.9 0.54 10.2 0.5 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat PGA2 PF07543.12 EMD60625.1 - 0.53 10.3 20.0 1.9 8.4 20.0 1.9 1 0 0 1 1 1 0 Protein trafficking PGA2 TPR_17 PF13431.6 EMD60625.1 - 0.72 10.4 2.5 1.2e+02 3.4 0.0 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat CDC45 PF02724.14 EMD60625.1 - 2.4 6.4 21.8 4.2 5.5 21.8 1.3 1 0 0 1 1 1 0 CDC45-like protein AAA_11 PF13086.6 EMD60625.1 - 4.8 6.9 10.6 13 5.4 10.6 1.7 1 0 0 1 1 1 0 AAA domain FAM60A PF15396.6 EMD60625.1 - 6.4 6.7 9.0 19 5.2 9.0 1.9 1 0 0 1 1 1 0 Protein Family FAM60A Cwf_Cwc_15 PF04889.12 EMD60625.1 - 8.2 6.1 29.8 2 8.1 24.7 2.3 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein AAA_16 PF13191.6 EMD60626.1 - 1.2e-06 29.1 0.2 4.4e-06 27.2 0.2 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 EMD60626.1 - 0.015 15.0 0.1 0.038 13.7 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_7 PF12775.7 EMD60626.1 - 0.033 13.7 0.0 0.11 12.0 0.0 1.8 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_25 PF13481.6 EMD60626.1 - 0.035 13.7 0.0 0.12 12.0 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 EMD60626.1 - 0.11 12.5 0.0 0.47 10.4 0.0 2.0 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EMD60626.1 - 0.47 10.7 3.0 13 6.1 1.9 3.1 2 1 0 2 2 2 0 AAA domain P16-Arc PF04699.14 EMD60629.1 - 3.8e-51 173.5 0.0 4.3e-51 173.3 0.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex 16 kDa subunit (p16-Arc) DUF3021 PF11457.8 EMD60631.1 - 0.046 14.1 6.8 1.4 9.3 3.0 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3021) UBA_4 PF14555.6 EMD60631.1 - 0.13 12.1 0.0 0.31 10.9 0.0 1.6 1 0 0 1 1 1 0 UBA-like domain MARVEL PF01284.23 EMD60631.1 - 0.77 9.8 13.1 3.5 7.7 12.9 1.9 1 1 0 1 1 1 0 Membrane-associating domain Yip1 PF04893.17 EMD60631.1 - 3.1 7.5 11.7 7 6.3 11.7 1.6 1 1 0 1 1 1 0 Yip1 domain Chalcone_2 PF16035.5 EMD60632.1 - 4.6e-67 225.8 0.0 6.4e-67 225.3 0.0 1.2 1 0 0 1 1 1 1 Chalcone isomerase like Chalcone_3 PF16036.5 EMD60632.1 - 0.0027 17.8 0.0 0.015 15.5 0.0 2.1 2 0 0 2 2 2 1 Chalcone isomerase-like DUF1678 PF07913.11 EMD60632.1 - 0.0055 16.5 0.1 0.016 15.0 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1678) DUF3452 PF11934.8 EMD60632.1 - 0.11 12.0 0.0 0.19 11.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3452) MAGE PF01454.19 EMD60633.1 - 4.5e-57 193.2 0.0 5.9e-57 192.8 0.0 1.1 1 0 0 1 1 1 1 MAGE family HTH_Tnp_Tc5 PF03221.16 EMD60633.1 - 0.18 11.8 0.0 0.3 11.1 0.0 1.4 1 0 0 1 1 1 0 Tc5 transposase DNA-binding domain DUF4149 PF13664.6 EMD60634.1 - 1.8e-23 82.8 4.6 1.8e-23 82.8 4.6 3.1 2 2 1 3 3 3 1 Domain of unknown function (DUF4149) Methyltransf_31 PF13847.6 EMD60635.1 - 3.4e-20 72.4 0.0 4.8e-20 71.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMD60635.1 - 4.9e-08 33.6 0.0 8.1e-08 32.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EMD60635.1 - 5.4e-07 29.6 0.0 6.8e-06 26.0 0.0 2.2 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMD60635.1 - 1.9e-06 28.5 0.0 2.9e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 EMD60635.1 - 7.3e-05 22.8 0.0 0.00011 22.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EMD60635.1 - 0.00058 19.2 0.0 0.00083 18.7 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_11 PF08241.12 EMD60635.1 - 0.00068 20.2 0.0 0.0013 19.3 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EMD60635.1 - 0.0027 17.3 0.0 0.0048 16.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Ubie_methyltran PF01209.18 EMD60635.1 - 0.014 14.8 0.0 0.022 14.1 0.0 1.5 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family MetW PF07021.12 EMD60635.1 - 0.016 14.8 0.0 0.031 13.9 0.0 1.5 2 0 0 2 2 2 0 Methionine biosynthesis protein MetW AdoMet_MTase PF07757.13 EMD60635.1 - 0.072 13.4 0.0 0.17 12.3 0.0 1.7 1 0 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase Methyltransf_4 PF02390.17 EMD60635.1 - 0.19 11.2 0.0 0.29 10.6 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase DUF4267 PF14087.6 EMD60636.1 - 7.1e-24 84.0 0.2 8.6e-24 83.8 0.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4267) PKcGMP_CC PF16808.5 EMD60637.1 - 0.0002 21.1 2.8 0.0002 21.1 2.8 3.4 2 1 2 4 4 4 2 Coiled-coil N-terminus of cGMP-dependent protein kinase FlaC_arch PF05377.11 EMD60637.1 - 0.14 12.6 5.5 0.63 10.5 1.0 3.3 3 1 1 4 4 4 0 Flagella accessory protein C (FlaC) SlyX PF04102.12 EMD60637.1 - 1.8 9.2 14.3 4.1 8.1 0.7 3.0 2 1 1 3 3 3 0 SlyX zf-C4H2 PF10146.9 EMD60637.1 - 2.4 8.4 12.2 0.14 12.4 6.9 1.7 2 0 0 2 2 2 0 Zinc finger-containing protein Adap_comp_sub PF00928.21 EMD60638.1 - 6.9e-56 189.5 0.0 8.5e-56 189.2 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 EMD60638.1 - 5.9e-05 23.0 0.0 9.8e-05 22.3 0.0 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain DUF4536 PF15055.6 EMD60639.1 - 1.6e-07 31.4 1.2 6.7e-07 29.4 0.2 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4536) DUF4588 PF15251.6 EMD60640.1 - 0.00011 22.1 0.5 0.00018 21.4 0.5 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF4588) peroxidase PF00141.23 EMD60642.1 - 6.1e-30 104.6 0.0 9e-30 104.1 0.0 1.3 1 0 0 1 1 1 1 Peroxidase Peroxidase_ext PF11895.8 EMD60642.1 - 4.4e-06 26.5 0.0 1.6e-05 24.8 0.0 1.9 2 0 0 2 2 2 1 Fungal peroxidase extension region Glyco_hydro_61 PF03443.14 EMD60643.1 - 2.6e-53 181.0 0.1 3.9e-53 180.4 0.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 CBM_1 PF00734.18 EMD60643.1 - 2e-09 37.2 7.5 4.8e-09 36.0 7.5 1.7 1 0 0 1 1 1 1 Fungal cellulose binding domain Cu-oxidase PF00394.22 EMD60644.1 - 3e-33 115.2 0.2 3e-29 102.2 0.0 2.5 2 0 0 2 2 2 2 Multicopper oxidase Cu-oxidase_3 PF07732.15 EMD60644.1 - 3.7e-33 114.0 1.0 3.7e-33 114.0 1.0 2.4 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 EMD60644.1 - 2.3e-31 108.4 13.1 8.9e-29 100.0 4.8 3.9 3 1 0 3 3 3 2 Multicopper oxidase adh_short_C2 PF13561.6 EMD60645.1 - 9.3e-47 159.5 0.0 1.1e-46 159.3 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EMD60645.1 - 5.7e-38 130.3 0.0 7.3e-38 130.0 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EMD60645.1 - 2.4e-08 34.1 0.1 5.3e-08 33.0 0.1 1.6 2 0 0 2 2 2 1 KR domain Epimerase PF01370.21 EMD60645.1 - 0.00013 21.6 1.2 0.00019 21.0 0.1 1.8 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EMD60645.1 - 0.0046 16.4 0.0 0.0071 15.8 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase TrkA_N PF02254.18 EMD60645.1 - 0.017 15.4 0.0 0.031 14.5 0.0 1.4 1 0 0 1 1 1 0 TrkA-N domain Polysacc_synt_2 PF02719.15 EMD60645.1 - 0.027 13.6 0.0 0.039 13.1 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein 3HCDH_N PF02737.18 EMD60645.1 - 0.033 14.1 0.1 0.14 12.1 0.0 1.9 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_2 PF03446.15 EMD60645.1 - 0.045 13.9 0.0 0.093 12.9 0.0 1.5 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Duffy_binding PF05424.11 EMD60645.1 - 0.055 13.5 0.1 0.099 12.7 0.1 1.4 1 0 0 1 1 1 0 Duffy binding domain ApbA PF02558.16 EMD60645.1 - 0.099 12.3 0.1 0.16 11.6 0.1 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA RNase_H PF00075.24 EMD60646.1 - 8.5e-05 22.8 0.1 0.00015 22.0 0.1 1.4 1 0 0 1 1 1 1 RNase H DUF3018 PF11455.8 EMD60646.1 - 0.13 12.2 0.0 0.33 10.9 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3018) DUF364 PF04016.12 EMD60647.1 - 0.11 12.0 0.0 0.23 11.0 0.0 1.5 1 0 0 1 1 1 0 Putative heavy-metal chelation PVL_ORF50 PF07768.11 EMD60647.1 - 0.14 12.4 3.3 0.28 11.5 3.3 1.4 1 0 0 1 1 1 0 PVL ORF-50-like family EBP PF05241.12 EMD60648.1 - 5.1e-07 29.3 0.5 7.5e-07 28.8 0.5 1.3 1 0 0 1 1 1 1 Emopamil binding protein DUF3302 PF11742.8 EMD60648.1 - 9.3 6.5 8.9 3.5 7.8 2.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3302) Cellulase PF00150.18 EMD60651.1 - 1.2e-10 41.3 0.3 1.9e-10 40.6 0.3 1.2 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Whi5 PF08528.11 EMD60652.1 - 0.00034 20.1 2.5 0.00062 19.3 2.5 1.5 1 0 0 1 1 1 1 Whi5 like Pal1 PF08316.11 EMD60653.1 - 1.8e-43 148.6 3.1 5.3e-42 143.8 0.2 2.9 2 0 0 2 2 2 2 Pal1 cell morphology protein Med31 PF05669.12 EMD60654.1 - 2e-34 117.4 0.7 2.3e-34 117.2 0.7 1.0 1 0 0 1 1 1 1 SOH1 RabGAP-TBC PF00566.18 EMD60655.1 - 2.9e-29 102.3 0.2 4.9e-29 101.5 0.2 1.4 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Rad51 PF08423.11 EMD60656.1 - 3e-07 30.0 0.1 5.4e-07 29.1 0.1 1.3 1 0 0 1 1 1 1 Rad51 RecA PF00154.21 EMD60656.1 - 8.2e-05 22.2 0.0 0.00085 18.9 0.1 2.1 2 0 0 2 2 2 1 recA bacterial DNA recombination protein A_deamin PF02137.18 EMD60657.1 - 2.6e-30 106.0 0.0 3.2e-30 105.7 0.0 1.1 1 0 0 1 1 1 1 Adenosine-deaminase (editase) domain NT-C2 PF10358.9 EMD60658.1 - 1.4e-35 122.1 0.0 2e-35 121.7 0.0 1.2 1 0 0 1 1 1 1 N-terminal C2 in EEIG1 and EHBP1 proteins SLS PF14611.6 EMD60659.1 - 3.6e-39 134.9 0.8 6.2e-39 134.1 0.5 1.6 2 0 0 2 2 2 1 Mitochondrial inner-membrane-bound regulator NMT1 PF09084.11 EMD60660.1 - 1.1e-76 257.6 0.0 4e-76 255.7 0.0 1.7 2 0 0 2 2 2 1 NMT1/THI5 like NMT1_2 PF13379.6 EMD60660.1 - 5.3e-06 26.3 0.0 0.066 12.9 0.0 2.9 3 0 0 3 3 3 2 NMT1-like family MltA PF03562.17 EMD60660.1 - 0.0026 17.6 0.2 0.56 9.9 0.1 2.4 3 0 0 3 3 3 2 MltA specific insert domain Phosphonate-bd PF12974.7 EMD60660.1 - 0.056 13.0 0.0 0.12 11.9 0.0 1.5 2 0 0 2 2 2 0 ABC transporter, phosphonate, periplasmic substrate-binding protein HET PF06985.11 EMD60661.1 - 3.3e-22 79.4 0.0 9.8e-22 77.9 0.0 1.9 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) DDE_Tnp_1_6 PF13751.6 EMD60661.1 - 0.15 12.3 0.7 0.25 11.6 0.7 1.3 1 0 0 1 1 1 0 Transposase DDE domain Homeobox_KN PF05920.11 EMD60662.1 - 5.6e-14 51.8 0.3 1.2e-13 50.7 0.3 1.6 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 EMD60662.1 - 3.3e-11 42.8 0.2 7.5e-11 41.7 0.2 1.6 1 0 0 1 1 1 1 Homeodomain YdaS_antitoxin PF15943.5 EMD60662.1 - 0.024 14.5 0.0 0.051 13.4 0.0 1.5 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT PHD_4 PF16866.5 EMD60662.1 - 4.6 7.4 11.4 2.4 8.3 1.4 3.6 2 1 0 2 2 2 0 PHD-finger LysM PF01476.20 EMD60663.1 - 1.7e-09 37.6 0.0 2.7e-09 36.9 0.0 1.3 1 0 0 1 1 1 1 LysM domain DUF903 PF06004.12 EMD60663.1 - 0.069 13.1 0.3 0.14 12.1 0.3 1.4 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF903) Hydrophobin PF01185.18 EMD60664.1 - 5.9e-12 46.1 8.8 8.1e-12 45.6 8.8 1.2 1 0 0 1 1 1 1 Fungal hydrophobin Glyoxalase PF00903.25 EMD60665.1 - 7e-08 32.7 0.4 7.2e-07 29.4 0.4 2.0 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Helo_like_N PF17111.5 EMD60666.1 - 1.5e-82 276.0 6.2 9.7e-77 257.0 1.4 2.2 2 0 0 2 2 2 2 Fungal N-terminal domain of STAND proteins PRESAN PF09687.10 EMD60666.1 - 0.067 13.7 0.0 0.21 12.1 0.0 1.8 2 0 0 2 2 2 0 Plasmodium RESA N-terminal RVT_1 PF00078.27 EMD60670.1 - 0.083 12.4 0.4 0.092 12.2 0.4 1.1 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_1 PF00078.27 EMD60671.1 - 3.9e-08 33.1 2.5 4.1e-08 33.0 2.5 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF2469 PF10611.9 EMD60671.1 - 0.015 15.8 0.4 0.023 15.2 0.2 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2469) DDE_1 PF03184.19 EMD60672.1 - 1.2e-17 64.1 0.0 1.3e-17 64.0 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.6 EMD60672.1 - 0.0035 17.1 0.1 0.0049 16.6 0.1 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease SF3a60_bindingd PF12108.8 EMD60674.1 - 0.027 14.3 2.7 0.077 12.9 0.4 2.5 2 0 0 2 2 2 0 Splicing factor SF3a60 binding domain Na_Ca_ex PF01699.24 EMD60677.1 - 2.5e-36 124.9 42.5 1.5e-19 70.4 20.3 2.2 2 0 0 2 2 2 2 Sodium/calcium exchanger protein SBE2 PF17076.5 EMD60677.1 - 0.48 8.6 8.2 0.68 8.1 8.2 1.2 1 0 0 1 1 1 0 SBE2, cell-wall formation Polysacc_deac_1 PF01522.21 EMD60678.1 - 1.8e-26 92.5 0.0 2.4e-26 92.0 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide deacetylase Glyco_hydro_57 PF03065.15 EMD60678.1 - 7.7e-05 22.0 0.0 9e-05 21.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 57 Pmp3 PF01679.17 EMD60679.1 - 1.8e-19 69.6 9.4 2.1e-19 69.4 9.4 1.1 1 0 0 1 1 1 1 Proteolipid membrane potential modulator LPD28 PF18843.1 EMD60680.1 - 0.13 11.9 0.0 0.26 10.9 0.0 1.5 1 0 0 1 1 1 0 Large polyvalent protein associated domain 28 Sec39 PF08314.11 EMD60684.1 - 1.8e-257 856.7 0.1 2e-257 856.5 0.1 1.0 1 0 0 1 1 1 1 Secretory pathway protein Sec39 DUF4097 PF13349.6 EMD60686.1 - 1.5e-05 24.5 9.4 0.00036 19.9 1.6 2.5 1 1 1 2 2 2 2 Putative adhesin DUF4451 PF14616.6 EMD60687.1 - 1.7e-22 79.9 0.0 3.2e-22 79.0 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4451) NmrA PF05368.13 EMD60688.1 - 2.5e-11 43.6 0.2 9.8e-11 41.6 0.2 1.8 1 1 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EMD60688.1 - 0.0018 18.2 0.0 0.0037 17.2 0.0 1.5 1 0 0 1 1 1 1 NAD(P)H-binding Fun_ATP-synt_8 PF05933.13 EMD60689.1 - 3.3e-19 68.8 7.6 4.5e-19 68.3 7.6 1.2 1 0 0 1 1 1 1 Fungal ATP synthase protein 8 (A6L) DUF3671 PF12420.8 EMD60689.1 - 0.06 13.4 0.0 0.067 13.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function MFS_1 PF07690.16 EMD60690.1 - 3.2e-38 131.6 21.9 2.2e-35 122.2 5.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 EMD60690.1 - 0.00069 18.0 1.4 0.0026 16.1 0.0 2.2 2 0 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family DUF4381 PF14316.6 EMD60690.1 - 0.046 14.0 1.7 0.15 12.3 0.6 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4381) DUF3522 PF12036.8 EMD60690.1 - 2.5 8.4 7.6 0.65 10.2 0.4 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF3522) DUF1772 PF08592.11 EMD60691.1 - 2.4e-30 105.6 3.7 3.1e-30 105.3 3.7 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1772) TMEM237 PF15383.6 EMD60691.1 - 0.034 13.2 0.1 0.045 12.8 0.1 1.2 1 0 0 1 1 1 0 Transmembrane protein 237 ETC_C1_NDUFA5 PF04716.14 EMD60692.1 - 0.0067 16.2 0.2 0.015 15.0 0.1 1.6 1 1 0 1 1 1 1 ETC complex I subunit conserved region LRR_6 PF13516.6 EMD60693.1 - 2.3e-15 55.3 17.2 0.0064 16.4 0.0 8.3 9 0 0 9 9 9 5 Leucine Rich repeat F-box-like PF12937.7 EMD60693.1 - 1.4e-13 50.5 0.7 2.7e-13 49.6 0.7 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EMD60693.1 - 1.1e-09 38.0 0.1 3.7e-09 36.2 0.1 2.0 1 0 0 1 1 1 1 F-box domain LRR_4 PF12799.7 EMD60693.1 - 0.0035 17.7 16.0 0.78 10.3 0.0 6.3 5 1 0 5 5 5 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EMD60693.1 - 0.041 14.4 21.0 4.5 8.2 0.1 6.8 7 0 0 7 7 7 0 Leucine Rich Repeat PRANC PF09372.10 EMD60693.1 - 0.13 12.6 0.0 0.39 11.1 0.0 1.8 1 0 0 1 1 1 0 PRANC domain 2OG-FeII_Oxy_2 PF13532.6 EMD60694.1 - 1.2e-13 51.7 0.0 8.3e-12 45.7 0.0 2.1 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily CDH-cyt PF16010.5 EMD60695.1 - 2.8e-26 92.3 6.1 4.7e-26 91.6 6.1 1.3 1 0 0 1 1 1 1 Cytochrome domain of cellobiose dehydrogenase DOMON PF03351.17 EMD60695.1 - 1.3e-06 28.6 0.2 3.2e-06 27.4 0.2 1.5 1 0 0 1 1 1 1 DOMON domain Cytochrom_B561 PF03188.16 EMD60695.1 - 2.1 8.5 16.6 4.2 7.5 16.6 1.5 1 0 0 1 1 1 0 Eukaryotic cytochrome b561 EB1 PF03271.17 EMD60697.1 - 6.1e-18 64.8 1.5 6.1e-18 64.8 1.5 1.9 2 0 0 2 2 2 1 EB1-like C-terminal motif CH PF00307.31 EMD60697.1 - 1.4e-07 31.6 0.8 2.6e-07 30.8 0.5 1.5 2 0 0 2 2 2 1 Calponin homology (CH) domain CH_2 PF06294.11 EMD60697.1 - 0.011 15.8 0.3 0.018 15.2 0.3 1.4 1 0 0 1 1 1 0 CH-like domain in sperm protein Syja_N PF02383.18 EMD60697.1 - 0.068 12.5 0.0 0.073 12.4 0.0 1.1 1 0 0 1 1 1 0 SacI homology domain ASFV_J13L PF05568.11 EMD60698.1 - 0.073 12.8 1.3 0.082 12.7 1.3 1.1 1 0 0 1 1 1 0 African swine fever virus J13L protein Abhydrolase_1 PF00561.20 EMD60699.1 - 3.8e-15 56.2 0.1 2e-09 37.5 0.0 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EMD60699.1 - 9.4e-15 55.8 0.0 1.6e-14 55.1 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EMD60699.1 - 1.4e-08 34.3 0.0 2.4e-08 33.5 0.0 1.4 1 1 0 1 1 1 1 Serine aminopeptidase, S33 PX PF00787.24 EMD60700.1 - 3.1e-14 52.9 0.0 1.1e-13 51.1 0.0 2.0 1 1 1 2 2 2 1 PX domain Aldolase_II PF00596.21 EMD60701.1 - 2.5e-26 92.8 0.0 3e-26 92.5 0.0 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain Fungal_trans PF04082.18 EMD60702.1 - 6.6e-28 97.5 0.0 1.4e-27 96.4 0.0 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD60702.1 - 3.2e-09 36.8 13.0 5.6e-09 36.0 13.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF3824 PF12868.7 EMD60702.1 - 0.014 16.0 0.4 0.014 16.0 0.4 2.0 2 0 0 2 2 2 0 Domain of unknwon function (DUF3824) Abhydrolase_1 PF00561.20 EMD60703.1 - 7.5e-13 48.7 0.0 1.2e-12 48.0 0.0 1.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EMD60703.1 - 1.2e-10 41.1 0.0 2.4e-10 40.1 0.0 1.5 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EMD60703.1 - 3e-10 41.1 0.0 4e-10 40.7 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Esterase PF00756.20 EMD60703.1 - 0.0012 18.5 0.0 0.0017 18.0 0.0 1.3 1 0 0 1 1 1 1 Putative esterase Peptidase_S9 PF00326.21 EMD60703.1 - 0.0044 16.5 0.0 0.82 9.1 0.0 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family Thioesterase PF00975.20 EMD60703.1 - 0.011 15.8 0.0 0.02 15.0 0.0 1.3 1 0 0 1 1 1 0 Thioesterase domain DUF2048 PF09752.9 EMD60703.1 - 0.017 14.2 0.0 0.03 13.4 0.0 1.3 1 0 0 1 1 1 0 Abhydrolase domain containing 18 Palm_thioest PF02089.15 EMD60703.1 - 0.059 13.2 0.0 0.097 12.5 0.0 1.4 1 0 0 1 1 1 0 Palmitoyl protein thioesterase PGAP1 PF07819.13 EMD60703.1 - 0.12 12.1 0.0 0.18 11.5 0.0 1.2 1 0 0 1 1 1 0 PGAP1-like protein MFS_1 PF07690.16 EMD60704.1 - 1.1e-36 126.6 45.9 9.7e-36 123.4 27.2 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Kinocilin PF15033.6 EMD60704.1 - 1.4 8.6 4.7 23 4.7 2.1 2.7 1 1 1 2 2 2 0 Kinocilin protein p450 PF00067.22 EMD60705.1 - 6.5e-33 114.2 0.0 9.1e-33 113.7 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Dynamin_M PF01031.20 EMD60705.1 - 0.046 12.9 0.0 0.45 9.7 0.0 2.0 2 0 0 2 2 2 0 Dynamin central region PIG-F PF06699.11 EMD60705.1 - 0.14 12.3 0.1 0.14 12.3 0.1 1.7 2 0 0 2 2 2 0 GPI biosynthesis protein family Pig-F Glyco_hydro_61 PF03443.14 EMD60707.1 - 5.3e-46 157.1 0.0 7.9e-46 156.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 CBM_1 PF00734.18 EMD60707.1 - 7.6e-10 38.6 9.9 2.6e-09 36.9 9.9 2.0 1 0 0 1 1 1 1 Fungal cellulose binding domain HAD PF12710.7 EMD60708.1 - 2.5e-19 70.4 0.0 3.6e-19 69.9 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EMD60708.1 - 7.3e-15 55.8 0.4 1.4e-14 54.9 0.4 1.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EMD60708.1 - 5.2e-09 36.2 0.1 5.5e-08 32.9 0.0 2.3 2 1 1 3 3 3 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EMD60708.1 - 3.8e-05 23.8 0.2 0.0024 18.0 0.2 2.9 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.12 EMD60708.1 - 0.00058 19.3 0.0 0.016 14.6 0.0 2.1 1 1 0 1 1 1 1 Putative Phosphatase DUF705 PF05152.12 EMD60708.1 - 0.04 13.4 0.0 0.075 12.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF705) adh_short PF00106.25 EMD60709.1 - 1e-31 109.9 0.0 4.7e-19 68.6 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EMD60709.1 - 1.6e-23 83.5 0.0 8.9e-22 77.8 0.0 2.1 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD60709.1 - 1.7e-08 34.6 0.0 2e-05 24.6 0.0 2.1 2 0 0 2 2 2 2 KR domain Epimerase PF01370.21 EMD60709.1 - 0.0098 15.4 0.2 0.059 12.8 0.1 2.2 3 0 0 3 3 3 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EMD60709.1 - 0.095 12.1 0.0 0.15 11.4 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Glyco_transf_28 PF03033.20 EMD60710.1 - 1.9e-17 63.6 0.1 1.2e-16 61.0 0.1 2.2 1 1 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain UDPGT PF00201.18 EMD60710.1 - 1e-07 31.1 0.0 1.8e-07 30.4 0.0 1.3 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 EMD60710.1 - 7.1e-05 22.9 0.0 0.00018 21.5 0.0 1.6 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain PHD PF00628.29 EMD60711.1 - 6.8e-10 38.7 8.4 1.6e-09 37.5 8.4 1.7 1 0 0 1 1 1 1 PHD-finger zf-CpG_bind_C PF12269.8 EMD60711.1 - 0.011 15.5 0.4 0.011 15.5 0.4 2.1 2 0 0 2 2 2 0 CpG binding protein zinc finger C terminal domain AvrM-A PF18241.1 EMD60711.1 - 0.46 10.9 5.3 0.57 10.6 1.1 2.5 2 0 0 2 2 2 0 Flax-rust effector AvrM-A Ribosomal_60s PF00428.19 EMD60711.1 - 0.51 10.9 10.0 17 6.1 0.1 3.3 2 0 0 2 2 2 0 60s Acidic ribosomal protein COesterase PF00135.28 EMD60712.1 - 3.7e-59 201.0 0.0 5.7e-59 200.3 0.0 1.2 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EMD60712.1 - 1.4e-06 28.3 0.1 0.049 13.5 0.1 2.3 2 0 0 2 2 2 2 alpha/beta hydrolase fold Esterase PF00756.20 EMD60712.1 - 0.011 15.4 0.0 0.035 13.8 0.0 1.7 2 0 0 2 2 2 0 Putative esterase DUF2974 PF11187.8 EMD60712.1 - 0.041 13.4 0.0 0.064 12.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Peptidase_S9 PF00326.21 EMD60712.1 - 0.044 13.3 0.0 0.071 12.6 0.0 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family Sugar_tr PF00083.24 EMD60713.1 - 1.4e-72 245.0 22.2 1.5e-72 244.9 22.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD60713.1 - 6.9e-18 64.7 35.9 1.5e-17 63.5 29.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EMD60713.1 - 0.00077 18.1 2.7 0.00077 18.1 2.7 3.1 2 1 0 3 3 3 1 MFS/sugar transport protein Arteri_Gl PF00951.18 EMD60713.1 - 0.79 9.5 6.0 0.44 10.3 3.1 2.0 1 1 0 1 1 1 0 Arterivirus GL envelope glycoprotein Glyco_hydro_32N PF00251.20 EMD60715.1 - 1.7e-44 152.7 0.0 4.3e-44 151.3 0.0 1.5 1 1 0 1 1 1 1 Glycosyl hydrolases family 32 N-terminal domain Glyco_hydro_32C PF08244.12 EMD60715.1 - 3.8e-23 82.2 0.0 6e-23 81.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 C terminal BNR PF02012.20 EMD60715.1 - 4.3 7.7 5.6 7.1 7.1 0.7 3.0 2 0 0 2 2 2 0 BNR/Asp-box repeat Glyco_hydro_10 PF00331.20 EMD60717.1 - 2e-101 339.3 1.7 2.4e-101 339.1 1.7 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 10 CBM_1 PF00734.18 EMD60717.1 - 1.5e-12 47.3 9.1 1.5e-12 47.3 9.1 2.4 3 0 0 3 3 3 1 Fungal cellulose binding domain LysM PF01476.20 EMD60719.1 - 4.3e-23 81.1 5.8 0.0096 16.0 0.0 8.1 8 0 0 8 8 8 6 LysM domain DUF4348 PF14254.6 EMD60719.1 - 0.0012 18.3 0.0 7.5 5.9 0.0 3.3 3 0 0 3 3 3 2 Domain of unknown function (DUF4348) HTH_Tnp_1 PF01527.20 EMD60719.1 - 0.055 13.8 0.0 1.2e+02 3.1 0.0 3.9 4 0 0 4 4 4 0 Transposase Glyco_hydro_18 PF00704.28 EMD60720.1 - 2.3e-70 237.8 2.3 4e-70 237.0 2.3 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Chitin_bind_1 PF00187.19 EMD60720.1 - 9.2e-12 45.2 15.7 9.2e-12 45.2 15.7 4.7 4 0 0 4 4 4 1 Chitin recognition protein Abhydrolase_6 PF12697.7 EMD60723.1 - 0.00024 21.8 0.0 0.0055 17.3 0.0 1.8 1 1 1 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_8 PF06259.12 EMD60723.1 - 0.066 12.8 0.0 0.089 12.4 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase TPP_enzyme_N PF02776.18 EMD60724.1 - 0.00013 21.7 0.0 0.00013 21.6 0.0 1.0 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain DUF3810 PF12725.7 EMD60725.1 - 0.0087 15.4 0.3 0.02 14.2 0.3 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF3810) DUF3144 PF11342.8 EMD60725.1 - 0.23 11.8 2.7 0.29 11.4 1.7 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3144) FAD_SOX PF18371.1 EMD60728.1 - 0.025 14.9 0.9 2.2 8.7 0.1 2.1 1 1 1 2 2 2 0 Flavin adenine dinucleotide (FAD)-dependent sulfhydryl oxidase Integrase_H2C2 PF17921.1 EMD60728.1 - 0.056 13.6 0.0 0.087 12.9 0.0 1.4 1 0 0 1 1 1 0 Integrase zinc binding domain PRANC PF09372.10 EMD60728.1 - 0.14 12.5 7.7 0.064 13.6 2.4 2.1 1 1 1 2 2 2 0 PRANC domain DNA_meth_N PF18284.1 EMD60729.1 - 0.061 13.2 0.1 0.073 13.0 0.1 1.1 1 0 0 1 1 1 0 DNA methylase N-terminal domain Ank_4 PF13637.6 EMD60731.1 - 1.3e-19 70.3 0.4 8.2e-11 42.2 0.1 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 EMD60731.1 - 1.7e-15 56.7 0.5 6.9e-05 23.1 0.1 3.1 3 0 0 3 3 3 3 Ankyrin repeat Ank_2 PF12796.7 EMD60731.1 - 6.3e-15 55.5 0.3 1e-14 54.9 0.3 1.5 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EMD60731.1 - 2.2e-11 42.9 0.0 0.01 16.3 0.0 3.1 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.6 EMD60731.1 - 4.3e-08 33.3 0.3 7.4e-06 26.1 0.2 2.2 1 1 1 2 2 2 2 Ankyrin repeats (many copies) DUF4142 PF13628.6 EMD60731.1 - 0.041 14.1 0.0 6.7 6.9 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4142) FLgD_tudor PF13861.6 EMD60731.1 - 0.069 13.4 0.0 6.5 7.1 0.0 2.5 2 0 0 2 2 2 0 FlgD Tudor-like domain Ank_2 PF12796.7 EMD60732.1 - 5.5e-14 52.5 0.5 1.7e-13 50.9 0.5 1.9 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMD60732.1 - 2.5e-10 40.7 0.4 2e-05 25.1 0.0 3.7 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMD60732.1 - 3.2e-10 39.4 1.1 0.00019 21.6 0.0 4.1 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.30 EMD60732.1 - 3.3e-10 39.9 0.5 0.024 15.1 0.0 4.1 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 EMD60732.1 - 7.3e-07 29.4 0.1 0.00017 21.8 0.0 3.2 2 1 1 3 3 3 2 Ankyrin repeats (many copies) VKOR PF07884.14 EMD60734.1 - 0.0023 18.1 10.5 0.028 14.6 0.3 2.1 2 0 0 2 2 2 2 Vitamin K epoxide reductase family DUF2976 PF11190.8 EMD60734.1 - 0.04 13.7 4.8 0.16 11.8 0.0 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF2976) RrnaAD PF00398.20 EMD60734.1 - 0.052 12.6 0.0 0.083 11.9 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase DUF2417 PF10329.9 EMD60734.1 - 0.8 9.1 6.1 0.13 11.7 0.6 2.1 1 1 1 2 2 2 0 Region of unknown function (DUF2417) GWT1 PF06423.12 EMD60734.1 - 1.1 9.4 4.3 12 6.0 4.3 2.2 1 1 0 1 1 1 0 GWT1 PilS PF08805.11 EMD60735.1 - 0.0086 15.9 0.4 0.014 15.2 0.3 1.4 1 1 0 1 1 1 1 PilS N terminal TcpE PF12648.7 EMD60735.1 - 0.15 12.6 0.7 0.34 11.5 0.1 1.8 2 0 0 2 2 2 0 TcpE family EHN PF06441.12 EMD60736.1 - 3.3e-28 98.2 0.1 6.2e-28 97.3 0.1 1.4 1 0 0 1 1 1 1 Epoxide hydrolase N terminus Abhydrolase_1 PF00561.20 EMD60736.1 - 9.4e-14 51.7 0.0 1.4e-13 51.1 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EMD60736.1 - 1.8e-07 32.0 0.4 5.2e-07 30.5 0.1 2.0 2 1 0 2 2 2 1 Alpha/beta hydrolase family Glyco_hydro_43 PF04616.14 EMD60737.1 - 4e-64 216.7 5.8 5e-64 216.4 5.8 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 GH43_C2 PF17851.1 EMD60737.1 - 2.2e-20 73.2 0.0 3.7e-20 72.5 0.0 1.3 1 0 0 1 1 1 1 Beta xylosidase C-terminal Concanavalin A-like domain Reg_prop PF07494.11 EMD60737.1 - 0.074 13.3 0.4 4.7 7.8 0.0 3.0 2 0 0 2 2 2 0 Two component regulator propeller ALO PF04030.14 EMD60740.1 - 0.00044 20.1 3.5 0.53 10.1 0.0 2.4 2 0 0 2 2 2 2 D-arabinono-1,4-lactone oxidase FAD_binding_4 PF01565.23 EMD60740.1 - 0.001 18.8 0.0 0.31 10.8 0.0 2.3 2 0 0 2 2 2 2 FAD binding domain Chol_subst-bind PF09129.11 EMD60740.1 - 0.8 8.6 9.3 1.1 8.1 5.6 2.8 1 1 1 2 2 2 0 Cholesterol oxidase, substrate-binding His_Phos_1 PF00300.22 EMD60741.1 - 2.1e-08 34.1 0.0 2.1e-08 34.1 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) DnaJ PF00226.31 EMD60742.1 - 2e-20 72.7 0.9 2e-20 72.7 0.9 2.1 2 0 0 2 2 2 1 DnaJ domain Cauli_DNA-bind PF03310.13 EMD60742.1 - 0.0042 17.1 1.4 0.0042 17.1 1.4 2.4 2 0 0 2 2 2 1 Caulimovirus DNA-binding protein zinc-ribbons_6 PF07191.12 EMD60742.1 - 0.36 10.8 7.2 7.6 6.6 7.8 2.4 1 1 1 2 2 2 0 zinc-ribbons MRFAP1 PF15155.6 EMD60744.1 - 0.0052 17.3 2.5 0.0081 16.7 2.5 1.2 1 0 0 1 1 1 1 MORF4 family-associated protein1 Med11 PF10280.9 EMD60744.1 - 0.013 16.0 1.1 0.018 15.5 1.1 1.2 1 0 0 1 1 1 0 Mediator complex protein HisKA_3 PF07730.13 EMD60744.1 - 0.71 10.4 3.6 17 6.0 0.4 2.9 2 1 1 3 3 3 0 Histidine kinase Exo_endo_phos_2 PF14529.6 EMD60747.1 - 7e-07 29.1 0.0 1.1e-06 28.5 0.0 1.3 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 EMD60747.1 - 0.1 12.1 0.0 0.1 12.1 0.0 1.2 1 1 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family eIF3g PF12353.8 EMD60748.1 - 2.5 8.5 14.7 1.7 9.1 1.1 3.3 2 1 1 3 3 3 0 Eukaryotic translation initiation factor 3 subunit G HisKA_3 PF07730.13 EMD60748.1 - 3.3 8.3 5.7 3.4 8.2 0.8 3.0 1 1 1 2 2 2 0 Histidine kinase DDE_1 PF03184.19 EMD60749.1 - 1.4e-19 70.5 0.2 3.2e-18 66.0 0.0 2.1 1 1 1 2 2 2 2 DDE superfamily endonuclease DDE_3 PF13358.6 EMD60749.1 - 0.017 14.9 0.1 0.025 14.3 0.1 1.4 1 1 0 1 1 1 0 DDE superfamily endonuclease DDE_1 PF03184.19 EMD60751.1 - 7.2e-11 42.1 0.0 6e-07 29.3 0.1 2.0 1 1 1 2 2 2 2 DDE superfamily endonuclease FPN1 PF06963.12 EMD60751.1 - 0.18 10.3 0.0 0.31 9.6 0.0 1.3 2 0 0 2 2 2 0 Ferroportin1 (FPN1) DUF3641 PF12345.8 EMD60752.1 - 0.12 12.4 0.2 0.14 12.2 0.2 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3641) PDH PF02153.17 EMD60754.1 - 1.8e-15 56.7 0.0 2.5e-15 56.2 0.0 1.2 1 0 0 1 1 1 1 Prephenate dehydrogenase Ribosomal_S11 PF00411.19 EMD60755.1 - 1.4e-46 157.4 1.6 1.8e-46 157.1 1.6 1.1 1 0 0 1 1 1 1 Ribosomal protein S11 Metallophos PF00149.28 EMD60756.1 - 3.9e-15 56.9 0.3 8.2e-15 55.9 0.3 1.6 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EMD60756.1 - 3e-08 34.1 0.5 1.9e-06 28.2 0.5 2.2 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Lactamase_B_2 PF12706.7 EMD60757.1 - 2.3e-27 95.8 0.0 7.8e-26 90.8 0.0 2.4 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 EMD60757.1 - 2.5e-11 43.8 0.0 5.8e-11 42.6 0.0 1.6 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 EMD60757.1 - 0.00039 20.5 2.1 0.32 11.0 1.0 3.1 3 0 0 3 3 3 2 Metallo-beta-lactamase superfamily Cyclin PF08613.11 EMD60759.1 - 6e-09 36.5 0.1 1.1e-08 35.7 0.1 1.4 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 EMD60759.1 - 0.044 13.5 0.1 0.068 12.9 0.1 1.2 1 0 0 1 1 1 0 Cyclin, N-terminal domain Herpes_capsid PF06112.11 EMD60760.1 - 9.7 6.2 10.9 10 6.1 8.9 2.0 2 0 0 2 2 2 0 Gammaherpesvirus capsid protein Ribosomal_L30_N PF08079.12 EMD60761.1 - 5.4e-25 87.4 18.7 5.4e-25 87.4 18.7 1.9 2 0 0 2 2 2 1 Ribosomal L30 N-terminal domain Ribosomal_L30 PF00327.20 EMD60761.1 - 1.9e-19 69.3 2.5 3.9e-19 68.3 2.5 1.6 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e Tipalpha PF16753.5 EMD60761.1 - 0.056 13.3 0.2 0.13 12.1 0.1 1.5 1 1 0 1 1 1 0 TNF-alpha-Inducing protein of Helicobacter CSRNP_N PF16019.5 EMD60761.1 - 0.21 11.5 4.6 0.32 10.9 4.6 1.2 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus adh_short PF00106.25 EMD60764.1 - 2.8e-24 85.7 0.0 3.5e-24 85.3 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD60764.1 - 4.1e-14 52.7 0.0 5.4e-14 52.3 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD60764.1 - 0.0001 22.3 0.1 0.00081 19.3 0.1 2.1 1 1 0 2 2 2 1 KR domain Epimerase PF01370.21 EMD60764.1 - 0.081 12.4 0.1 0.34 10.3 0.1 2.0 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Actin PF00022.19 EMD60765.1 - 3.1e-51 174.3 0.0 5.4e-27 94.4 0.0 2.3 2 0 0 2 2 2 2 Actin DUF3040 PF11239.8 EMD60765.1 - 0.056 13.7 0.1 0.15 12.3 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) DASH_Dad4 PF08650.10 EMD60766.1 - 7.4e-32 109.1 7.2 8.1e-32 109.0 7.2 1.0 1 0 0 1 1 1 1 DASH complex subunit Dad4 Biotin_carb_C PF02785.19 EMD60766.1 - 0.02 15.0 0.0 0.021 14.9 0.0 1.1 1 0 0 1 1 1 0 Biotin carboxylase C-terminal domain GM_CSF PF01109.17 EMD60766.1 - 0.044 14.0 0.4 0.049 13.8 0.4 1.1 1 0 0 1 1 1 0 Granulocyte-macrophage colony-stimulating factor DASH_Dad1 PF08649.10 EMD60766.1 - 0.089 13.0 3.5 0.12 12.6 3.5 1.3 1 0 0 1 1 1 0 DASH complex subunit Dad1 YL1_C PF08265.11 EMD60767.1 - 2.2e-16 59.3 0.3 3.4e-16 58.7 0.3 1.3 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain Got1 PF04178.12 EMD60768.1 - 1.8e-14 54.1 14.1 2.3e-14 53.7 14.1 1.1 1 0 0 1 1 1 1 Got1/Sft2-like family C166 PF17615.2 EMD60768.1 - 0.0062 16.7 2.7 0.0081 16.3 2.7 1.1 1 0 0 1 1 1 1 Family of unknown function Dicistro_VP4 PF11492.8 EMD60768.1 - 0.088 12.8 0.5 0.17 11.9 0.1 1.7 2 0 0 2 2 2 0 Cricket paralysis virus, VP4 SMC_Nse1 PF07574.13 EMD60769.1 - 6.2e-62 208.9 0.6 7.8e-62 208.6 0.6 1.1 1 0 0 1 1 1 1 Nse1 non-SMC component of SMC5-6 complex zf-RING-like PF08746.11 EMD60769.1 - 2.7e-14 53.2 8.8 4.6e-14 52.4 8.8 1.4 1 0 0 1 1 1 1 RING-like domain zf-HC5HC2H_2 PF13832.6 EMD60769.1 - 0.0059 16.8 1.3 0.011 15.8 1.3 1.5 1 0 0 1 1 1 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 EMD60769.1 - 0.05 13.9 6.3 0.14 12.5 6.3 1.7 1 1 0 1 1 1 0 PHD-like zinc-binding domain Not3 PF04065.15 EMD60769.1 - 0.061 12.7 0.1 0.095 12.1 0.1 1.3 1 0 0 1 1 1 0 Not1 N-terminal domain, CCR4-Not complex component FANCL_C PF11793.8 EMD60769.1 - 0.29 11.4 4.0 0.72 10.1 4.0 1.7 1 1 0 1 1 1 0 FANCL C-terminal domain zf-RING_2 PF13639.6 EMD60769.1 - 0.73 10.2 6.3 1.2 9.6 6.3 1.3 1 0 0 1 1 1 0 Ring finger domain C1_1 PF00130.22 EMD60769.1 - 8.5 6.3 8.9 0.64 9.9 2.2 2.1 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) DAHP_synth_1 PF00793.20 EMD60770.1 - 7.9e-104 346.4 0.0 9.9e-104 346.0 0.0 1.0 1 0 0 1 1 1 1 DAHP synthetase I family Y_phosphatase PF00102.27 EMD60772.1 - 4e-61 206.6 1.6 2e-32 112.7 0.2 2.7 2 1 0 2 2 2 2 Protein-tyrosine phosphatase Rhodanese PF00581.20 EMD60772.1 - 6.1e-11 42.8 0.0 2e-10 41.1 0.0 2.0 2 0 0 2 2 2 1 Rhodanese-like domain Y_phosphatase3 PF13350.6 EMD60772.1 - 0.0049 16.9 0.0 0.0091 16.0 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 EMD60772.1 - 0.011 15.5 0.0 0.027 14.3 0.0 1.7 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Lipase_3 PF01764.25 EMD60773.1 - 8.1e-05 22.5 0.0 0.00017 21.5 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) VPS9 PF02204.18 EMD60774.1 - 1.3e-25 89.6 0.0 4e-25 88.0 0.0 1.9 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain DUF5601 PF18151.1 EMD60774.1 - 0.1 13.0 0.0 0.61 10.4 0.0 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF5601) Fungal_TACC PF12709.7 EMD60775.1 - 1.4e-08 35.0 20.5 2.5e-08 34.2 2.9 4.0 4 0 0 4 4 4 2 Fungal Transforming acidic coiled-coil (TACC) proteins Tropomyosin_1 PF12718.7 EMD60775.1 - 9e-06 25.9 17.2 9e-06 25.9 17.2 3.5 2 1 0 2 2 2 1 Tropomyosin like DUF4407 PF14362.6 EMD60775.1 - 1.8e-05 24.3 44.6 0.022 14.1 10.3 3.2 2 1 0 2 2 2 2 Domain of unknown function (DUF4407) FPP PF05911.11 EMD60775.1 - 0.0011 17.3 15.7 0.0011 17.3 15.7 3.3 2 1 2 4 4 4 1 Filament-like plant protein, long coiled-coil DUF745 PF05335.13 EMD60775.1 - 0.0026 17.5 11.9 0.0026 17.5 11.9 3.9 2 1 2 4 4 4 1 Protein of unknown function (DUF745) Baculo_PEP_C PF04513.12 EMD60775.1 - 0.12 12.4 2.7 3.7 7.6 0.0 3.4 3 1 0 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Csm1_N PF18504.1 EMD60775.1 - 0.34 11.3 24.3 0.38 11.1 1.4 5.1 4 0 0 4 4 4 0 Csm1 N-terminal domain CENP-F_leu_zip PF10473.9 EMD60775.1 - 8.8 6.4 49.2 2.1 8.3 1.4 4.5 1 1 3 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 CFEM PF05730.11 EMD60779.1 - 3.5e-13 49.4 11.5 5.2e-13 48.9 11.5 1.3 1 0 0 1 1 1 1 CFEM domain GCIP PF13324.6 EMD60780.1 - 5.1e-28 98.4 3.5 5.1e-28 98.4 3.5 1.5 2 0 0 2 2 2 1 Grap2 and cyclin-D-interacting RRN3 PF05327.11 EMD60780.1 - 0.79 8.2 2.3 1.1 7.7 2.3 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 PRKCSH-like PF12999.7 EMD60781.1 - 6.6e-43 146.5 2.4 1.3e-23 83.7 0.4 2.6 2 0 0 2 2 2 2 Glucosidase II beta subunit-like PRKCSH_1 PF13015.6 EMD60781.1 - 2.7e-33 114.9 0.8 5.4e-32 110.6 0.2 2.3 2 0 0 2 2 2 1 Glucosidase II beta subunit-like protein PRKCSH PF07915.13 EMD60781.1 - 1.8e-10 41.7 1.2 3.8e-10 40.6 0.2 2.1 2 0 0 2 2 2 1 Glucosidase II beta subunit-like protein ATG27 PF09451.10 EMD60781.1 - 0.037 13.9 0.1 0.062 13.1 0.1 1.3 1 0 0 1 1 1 0 Autophagy-related protein 27 TPR_MLP1_2 PF07926.12 EMD60781.1 - 0.039 14.0 13.7 1.7 8.7 0.1 3.4 3 0 0 3 3 3 0 TPR/MLP1/MLP2-like protein Herpes_UL6 PF01763.16 EMD60781.1 - 0.043 12.3 1.6 0.07 11.6 0.3 1.7 1 1 1 2 2 2 0 Herpesvirus UL6 like Fib_alpha PF08702.10 EMD60781.1 - 0.14 12.3 1.2 3.8 7.7 0.1 2.6 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family DivIC PF04977.15 EMD60781.1 - 0.16 11.8 0.2 0.16 11.8 0.2 4.1 3 1 1 4 4 4 0 Septum formation initiator DUF5082 PF16888.5 EMD60781.1 - 0.21 11.9 5.9 28 5.0 0.1 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF5082) LMP PF04778.12 EMD60781.1 - 0.24 11.3 4.5 4.4 7.2 0.0 3.1 3 0 0 3 3 3 0 LMP repeated region DUF4570 PF15134.6 EMD60781.1 - 0.31 11.1 2.8 4.3 7.4 1.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4570) Mod_r PF07200.13 EMD60781.1 - 0.32 11.1 6.1 8.3 6.5 0.1 3.0 2 1 1 3 3 3 0 Modifier of rudimentary (Mod(r)) protein HIP1_clath_bdg PF16515.5 EMD60781.1 - 0.49 11.0 10.2 7.6 7.2 2.0 3.1 3 0 0 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Lectin_N PF03954.14 EMD60781.1 - 0.58 9.9 2.9 1 9.1 0.1 2.3 3 0 0 3 3 3 0 Hepatic lectin, N-terminal domain FAM184 PF15665.5 EMD60781.1 - 0.6 9.8 6.0 0.082 12.7 1.2 1.9 2 0 0 2 2 2 0 Family with sequence similarity 184, A and B Spc24 PF08286.11 EMD60781.1 - 1.1 9.6 6.2 6.7 7.0 0.4 3.2 2 1 1 3 3 3 0 Spc24 subunit of Ndc80 DUF2031 PF09592.10 EMD60781.1 - 1.1 8.7 3.3 0.41 10.1 0.6 1.5 2 0 0 2 2 1 0 Protein of unknown function (DUF2031) Filament PF00038.21 EMD60781.1 - 2.8 7.4 11.6 4.7 6.7 0.4 3.0 2 1 1 3 3 3 0 Intermediate filament protein DUF1192 PF06698.11 EMD60781.1 - 4.2 7.5 11.3 4.1 7.5 0.6 3.7 3 1 1 4 4 4 0 Protein of unknown function (DUF1192) Tup_N PF08581.10 EMD60781.1 - 5.7 7.3 6.3 16 5.9 0.4 2.9 3 0 0 3 3 3 0 Tup N-terminal DUF4140 PF13600.6 EMD60781.1 - 5.9 7.4 17.1 3.9 8.0 3.2 3.4 2 1 1 3 3 3 0 N-terminal domain of unknown function (DUF4140) Fzo_mitofusin PF04799.13 EMD60781.1 - 8.3 5.9 7.4 1.9 8.0 0.2 2.6 3 0 0 3 3 2 0 fzo-like conserved region APG6_N PF17675.1 EMD60781.1 - 8.3 6.9 12.7 10 6.7 0.5 3.2 2 1 1 3 3 3 0 Apg6 coiled-coil region DUF4200 PF13863.6 EMD60781.1 - 9.5 6.7 14.7 29 5.1 5.0 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4200) Phytase-like PF13449.6 EMD60782.1 - 7.1e-40 137.7 0.1 1.1e-39 137.1 0.1 1.3 1 0 0 1 1 1 1 Esterase-like activity of phytase DUF3328 PF11807.8 EMD60784.1 - 3.8e-22 79.2 0.1 5.3e-22 78.7 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) p450 PF00067.22 EMD60785.1 - 4.5e-65 220.2 0.0 5.8e-65 219.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Brr6_like_C_C PF10104.9 EMD60786.1 - 2.6e-43 147.0 1.1 2.6e-43 147.0 1.1 1.5 2 0 0 2 2 2 1 Di-sulfide bridge nucleocytoplasmic transport domain TFIIA PF03153.13 EMD60786.1 - 3.5 7.5 18.0 0.97 9.4 11.4 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit DUF1729 PF08354.10 EMD60787.1 - 4.1e-161 535.8 0.0 7.1e-161 535.0 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1729) Acyl_transf_1 PF00698.21 EMD60787.1 - 2.6e-87 293.3 0.3 4.1e-86 289.4 0.0 2.9 3 0 0 3 3 3 1 Acyl transferase domain FAS_meander PF17951.1 EMD60787.1 - 3.7e-52 176.0 0.0 1e-51 174.6 0.0 1.8 1 0 0 1 1 1 1 Fatty acid synthase meander beta sheet domain FAS_N PF17828.1 EMD60787.1 - 6.7e-38 129.6 0.1 3.7e-37 127.2 0.0 2.3 3 0 0 3 3 3 1 N-terminal domain in fatty acid synthase subunit beta SAT PF16073.5 EMD60787.1 - 3.2e-37 128.5 0.0 6.6e-37 127.5 0.0 1.5 1 0 0 1 1 1 1 Starter unit:ACP transacylase in aflatoxin biosynthesis MaoC_dehydratas PF01575.19 EMD60787.1 - 6.9e-37 125.8 0.0 1.5e-36 124.7 0.0 1.6 1 0 0 1 1 1 1 MaoC like domain MaoC_dehydrat_N PF13452.6 EMD60787.1 - 7.3e-25 87.6 0.0 2.7e-24 85.8 0.0 2.1 1 0 0 1 1 1 1 N-terminal half of MaoC dehydratase FAS_I_H PF18314.1 EMD60788.1 - 5.3e-81 271.1 0.1 5.3e-81 271.1 0.1 2.2 3 0 0 3 3 3 1 Fatty acid synthase type I helical domain Fas_alpha_ACP PF18325.1 EMD60788.1 - 1.5e-68 230.2 0.0 3.2e-68 229.1 0.0 1.6 1 0 0 1 1 1 1 Fatty acid synthase subunit alpha Acyl carrier domain ketoacyl-synt PF00109.26 EMD60788.1 - 2.1e-20 73.4 0.0 4.1e-20 72.4 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain ACPS PF01648.20 EMD60788.1 - 4.2e-19 68.8 0.0 9.2e-19 67.7 0.0 1.6 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily Ketoacyl-synt_C PF02801.22 EMD60788.1 - 6.8e-11 42.2 0.0 1.7e-10 41.0 0.0 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain adh_short PF00106.25 EMD60788.1 - 3.6e-05 23.3 0.0 7.5e-05 22.3 0.0 1.6 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD60788.1 - 0.0059 16.2 0.0 0.014 14.9 0.0 1.6 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD60788.1 - 0.015 15.2 0.1 0.06 13.3 0.0 2.1 2 0 0 2 2 2 0 KR domain Astacin PF01400.24 EMD60789.1 - 5.1e-12 45.8 0.3 1.1e-08 35.0 0.1 2.3 2 0 0 2 2 2 2 Astacin (Peptidase family M12A) Reprolysin_5 PF13688.6 EMD60789.1 - 0.086 13.0 0.7 0.13 12.4 0.2 1.5 1 1 0 1 1 1 0 Metallo-peptidase family M12 Peptidase_M10 PF00413.24 EMD60789.1 - 0.095 12.5 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 Matrixin Peptidase_M54 PF07998.11 EMD60789.1 - 0.11 12.5 0.2 0.17 11.8 0.2 1.3 1 0 0 1 1 1 0 Peptidase family M54 Peptidase_M57 PF12388.8 EMD60789.1 - 0.13 11.8 0.0 0.24 11.0 0.0 1.4 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase Git3 PF11710.8 EMD60791.1 - 1.8e-20 73.6 10.7 3.4e-20 72.7 10.7 1.4 1 1 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 Dicty_CAR PF05462.11 EMD60791.1 - 2.4e-09 36.8 11.1 1.1e-06 28.0 9.7 2.1 2 0 0 2 2 2 2 Slime mold cyclic AMP receptor Epimerase PF01370.21 EMD60791.1 - 0.03 13.8 0.0 0.049 13.1 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family GPR_Gpa2_C PF11970.8 EMD60791.1 - 0.059 13.4 3.1 0.087 12.9 0.0 2.7 3 0 0 3 3 3 0 G protein-coupled glucose receptor regulating Gpa2 C-term Methyltransf_2 PF00891.18 EMD60793.1 - 1.3e-09 37.6 0.0 1.6e-07 30.8 0.0 2.2 2 0 0 2 2 2 2 O-methyltransferase domain Dimerisation2 PF16864.5 EMD60793.1 - 0.0037 17.2 0.0 0.0082 16.1 0.0 1.6 1 0 0 1 1 1 1 Dimerisation domain Methyltransf_20 PF12147.8 EMD60793.1 - 0.17 11.0 0.3 0.76 8.9 0.0 2.1 3 0 0 3 3 3 0 Putative methyltransferase zf-RING_2 PF13639.6 EMD60794.1 - 3.1e-13 49.8 4.5 5e-13 49.2 4.5 1.3 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 EMD60794.1 - 2.3e-11 43.2 1.6 3.9e-11 42.5 1.6 1.4 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 EMD60794.1 - 9.9e-08 31.7 4.7 1.5e-07 31.1 4.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMD60794.1 - 3.4e-07 30.0 3.7 5.6e-07 29.3 3.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EMD60794.1 - 2.3e-06 27.8 5.0 6.3e-06 26.4 5.0 1.7 1 1 0 1 1 1 1 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 EMD60794.1 - 1.9e-05 24.4 4.0 3.6e-05 23.5 4.0 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EMD60794.1 - 2e-05 24.4 2.2 3.2e-05 23.8 2.2 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EMD60794.1 - 0.0012 18.7 1.3 0.0019 18.0 1.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EMD60794.1 - 0.0033 17.4 0.4 0.0068 16.4 0.4 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 EMD60794.1 - 0.0046 17.0 4.2 0.0091 16.0 4.2 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_4 PF14570.6 EMD60794.1 - 0.0088 15.8 3.1 0.017 14.9 3.1 1.4 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain PHD PF00628.29 EMD60794.1 - 0.24 11.3 3.0 0.44 10.5 3.0 1.5 1 0 0 1 1 1 0 PHD-finger zf-RING-like PF08746.11 EMD60794.1 - 0.28 11.5 1.9 0.47 10.8 1.9 1.4 1 0 0 1 1 1 0 RING-like domain Prok-RING_1 PF14446.6 EMD60794.1 - 0.87 9.6 2.7 1.1 9.2 0.9 1.9 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 FANCL_C PF11793.8 EMD60794.1 - 3.3 7.9 4.5 19 5.5 4.5 2.2 1 1 0 1 1 1 0 FANCL C-terminal domain Na_Ca_ex PF01699.24 EMD60795.1 - 1.9e-23 83.1 37.7 6.6e-14 52.1 11.1 3.6 3 1 0 3 3 3 2 Sodium/calcium exchanger protein YccF PF03733.13 EMD60795.1 - 2.2e-15 57.1 7.4 2.2e-15 57.1 7.4 4.5 4 0 0 4 4 4 1 Inner membrane component domain AAA PF00004.29 EMD60796.1 - 1e-43 148.9 0.0 1.7e-43 148.2 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EMD60796.1 - 5.1e-14 51.8 0.0 1e-13 50.9 0.0 1.5 1 0 0 1 1 1 1 AAA+ lid domain AAA_2 PF07724.14 EMD60796.1 - 9.9e-08 32.3 0.0 1.9e-07 31.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 EMD60796.1 - 6.2e-07 29.5 0.0 1.6e-06 28.2 0.0 1.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EMD60796.1 - 6.5e-07 29.9 0.0 3.9e-05 24.1 0.0 2.9 2 1 1 3 3 3 1 AAA ATPase domain Prot_ATP_ID_OB PF16450.5 EMD60796.1 - 1.4e-06 28.1 2.6 3.6e-06 26.8 2.6 1.8 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_22 PF13401.6 EMD60796.1 - 1.5e-05 25.3 0.2 0.0063 16.8 0.0 2.4 1 1 1 2 2 2 1 AAA domain RuvB_N PF05496.12 EMD60796.1 - 5.9e-05 22.9 0.0 0.00013 21.8 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain IstB_IS21 PF01695.17 EMD60796.1 - 0.001 18.9 0.0 0.0018 18.0 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein TIP49 PF06068.13 EMD60796.1 - 0.0011 18.2 0.0 0.0023 17.2 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_18 PF13238.6 EMD60796.1 - 0.0016 19.0 0.0 0.028 15.0 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EMD60796.1 - 0.002 18.3 0.0 0.004 17.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_3 PF07726.11 EMD60796.1 - 0.0054 16.6 0.0 0.015 15.1 0.0 1.8 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 EMD60796.1 - 0.0078 15.6 0.1 0.017 14.5 0.1 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI ATPase PF06745.13 EMD60796.1 - 0.0084 15.5 0.0 0.019 14.3 0.0 1.6 1 0 0 1 1 1 1 KaiC AAA_28 PF13521.6 EMD60796.1 - 0.0097 16.2 0.0 0.02 15.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain TsaE PF02367.17 EMD60796.1 - 0.01 15.8 0.0 0.02 14.9 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF815 PF05673.13 EMD60796.1 - 0.019 14.1 0.0 0.035 13.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Sigma54_activat PF00158.26 EMD60796.1 - 0.021 14.6 0.0 0.092 12.4 0.0 2.0 3 0 0 3 3 2 0 Sigma-54 interaction domain Prot_ATP_OB_N PF17758.1 EMD60796.1 - 0.023 14.3 0.1 0.083 12.6 0.1 2.0 1 1 0 1 1 1 0 Proteasomal ATPase OB N-terminal domain PhoH PF02562.16 EMD60796.1 - 0.026 14.0 0.0 0.1 12.1 0.0 1.9 2 0 0 2 2 2 0 PhoH-like protein AAA_7 PF12775.7 EMD60796.1 - 0.029 13.9 0.0 0.047 13.2 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_24 PF13479.6 EMD60796.1 - 0.038 13.7 0.0 0.1 12.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EMD60796.1 - 0.039 14.3 0.0 0.069 13.5 0.0 1.4 1 0 0 1 1 1 0 RNA helicase AAA_14 PF13173.6 EMD60796.1 - 0.042 13.9 0.0 0.071 13.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 EMD60796.1 - 0.048 13.2 0.1 0.21 11.2 0.0 1.9 2 0 0 2 2 2 0 AAA domain Parvo_NS1 PF01057.17 EMD60796.1 - 0.091 11.8 0.0 0.15 11.1 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 DUF2072 PF09845.9 EMD60796.1 - 0.15 12.4 0.1 0.28 11.4 0.1 1.4 1 0 0 1 1 1 0 Zn-ribbon containing protein DivIC PF04977.15 EMD60796.1 - 0.44 10.4 2.3 0.45 10.3 0.8 1.7 2 0 0 2 2 1 0 Septum formation initiator MFS_1 PF07690.16 EMD60797.1 - 6.2e-22 78.0 29.6 1.4e-14 53.8 16.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EMD60797.1 - 6.3e-12 45.1 21.5 2.6e-11 43.1 21.5 2.2 1 1 0 1 1 1 1 Sugar (and other) transporter DUF1345 PF07077.11 EMD60797.1 - 0.09 12.5 2.9 3 7.5 0.1 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1345) DUF2755 PF10954.8 EMD60797.1 - 1.2 9.1 4.7 2.1 8.3 0.1 3.3 3 1 0 3 3 3 0 Protein of unknown function (DUF2755) adh_short PF00106.25 EMD60798.1 - 2.4e-39 134.8 0.0 2.9e-39 134.5 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD60798.1 - 3.8e-30 105.2 0.0 4.4e-30 105.0 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD60798.1 - 9.2e-12 45.2 0.2 1.3e-11 44.8 0.2 1.2 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 EMD60798.1 - 3.5e-07 30.3 0.2 5e-07 29.8 0.2 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Polysacc_synt_2 PF02719.15 EMD60798.1 - 0.005 16.0 0.0 0.0084 15.3 0.0 1.3 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.21 EMD60798.1 - 0.012 15.1 0.1 0.02 14.4 0.1 1.4 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family TrkA_N PF02254.18 EMD60798.1 - 0.02 15.2 0.1 0.088 13.1 0.0 1.9 2 0 0 2 2 2 0 TrkA-N domain Sacchrp_dh_NADP PF03435.18 EMD60798.1 - 0.08 13.2 0.0 0.17 12.1 0.0 1.6 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain PFK PF00365.20 EMD60799.1 - 3e-190 630.5 4.7 6.2e-110 367.0 0.9 2.1 2 0 0 2 2 2 2 Phosphofructokinase DAGK_cat PF00781.24 EMD60799.1 - 0.044 13.4 0.3 0.24 11.0 0.1 2.4 2 0 0 2 2 2 0 Diacylglycerol kinase catalytic domain Nic96 PF04097.14 EMD60800.1 - 2.5e-205 683.6 0.0 3.4e-205 683.2 0.0 1.1 1 0 0 1 1 1 1 Nup93/Nic96 Med13_C PF06333.12 EMD60800.1 - 0.71 9.1 3.5 1.7 7.8 3.5 1.6 1 0 0 1 1 1 0 Mediator complex subunit 13 C-terminal domain Med27 PF11571.8 EMD60802.1 - 1.1e-13 51.3 0.2 2.5e-13 50.2 0.2 1.5 1 0 0 1 1 1 1 Mediator complex subunit 27 FMN_dh PF01070.18 EMD60803.1 - 3.1e-120 401.4 0.2 3.8e-120 401.1 0.2 1.1 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.28 EMD60803.1 - 1.4e-22 79.6 0.1 2.8e-22 78.7 0.1 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Glu_synthase PF01645.17 EMD60803.1 - 3.9e-08 32.8 0.2 8.5e-08 31.7 0.0 1.5 2 0 0 2 2 2 1 Conserved region in glutamate synthase IMPDH PF00478.25 EMD60803.1 - 9.9e-05 21.5 0.5 0.00027 20.1 0.2 1.7 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain NMO PF03060.15 EMD60803.1 - 0.0077 15.6 0.1 0.011 15.2 0.1 1.2 1 0 0 1 1 1 1 Nitronate monooxygenase ThiG PF05690.14 EMD60803.1 - 0.04 13.2 0.2 7.6 5.8 0.0 2.2 2 0 0 2 2 2 0 Thiazole biosynthesis protein ThiG His_biosynth PF00977.21 EMD60803.1 - 0.049 13.1 1.6 1.2 8.6 0.2 2.2 1 1 0 2 2 2 0 Histidine biosynthesis protein Cytotoxic PF09000.10 EMD60803.1 - 0.091 13.1 0.1 0.26 11.7 0.0 1.8 2 0 0 2 2 2 0 Cytotoxic Pro_CA PF00484.19 EMD60803.1 - 0.14 12.5 0.0 0.28 11.5 0.0 1.4 1 0 0 1 1 1 0 Carbonic anhydrase Ras PF00071.22 EMD60804.1 - 6.7e-41 139.6 0.0 4.5e-38 130.4 0.0 2.1 2 0 0 2 2 2 2 Ras family Roc PF08477.13 EMD60804.1 - 9e-33 113.0 0.0 1.4e-32 112.4 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMD60804.1 - 2.4e-12 46.6 0.0 4.1e-12 45.9 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EMD60804.1 - 0.0002 21.4 0.0 0.00056 20.0 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_16 PF13191.6 EMD60804.1 - 0.0006 20.2 0.0 0.0016 18.8 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain PduV-EutP PF10662.9 EMD60804.1 - 0.0055 16.5 0.1 0.59 9.9 0.0 2.5 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation Gtr1_RagA PF04670.12 EMD60804.1 - 0.0055 16.1 0.0 0.0078 15.6 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 EMD60804.1 - 0.015 14.7 0.0 0.028 13.9 0.0 1.5 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_24 PF13479.6 EMD60804.1 - 0.058 13.1 0.0 0.12 12.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 EMD60804.1 - 0.076 12.9 0.3 0.34 10.8 0.2 2.1 2 1 1 3 3 3 0 RsgA GTPase AAA_28 PF13521.6 EMD60804.1 - 0.21 11.8 0.6 2 8.7 0.1 2.2 2 0 0 2 2 2 0 AAA domain Amidohydro_1 PF01979.20 EMD60805.1 - 1.6e-17 63.8 0.0 3.4e-17 62.8 0.0 1.5 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EMD60805.1 - 9e-13 48.5 0.6 9.8e-11 41.8 0.1 2.1 2 0 0 2 2 2 2 Amidohydrolase family Glyco_hydro_3 PF00933.21 EMD60806.1 - 1.5e-64 218.4 0.0 1.9e-64 218.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Acetyltransf_1 PF00583.25 EMD60806.1 - 8.3e-06 26.0 0.0 4.3e-05 23.7 0.0 2.2 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Glyco_hydro_3_C PF01915.22 EMD60806.1 - 0.0002 21.3 0.0 0.0004 20.4 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Acetyltransf_10 PF13673.7 EMD60806.1 - 0.093 12.7 0.0 0.22 11.5 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain NDT80_PhoG PF05224.12 EMD60807.1 - 1.2e-35 123.4 0.0 2.5e-35 122.4 0.0 1.5 1 0 0 1 1 1 1 NDT80 / PhoG like DNA-binding family Hexokinase_2 PF03727.16 EMD60808.1 - 1.9e-60 204.3 0.0 2.6e-60 203.8 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 EMD60808.1 - 1.3e-48 165.6 0.0 2.1e-48 164.9 0.0 1.3 1 0 0 1 1 1 1 Hexokinase MFS_1 PF07690.16 EMD60809.1 - 1.1e-12 47.6 33.3 1.8e-12 46.9 32.9 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily UNC-93 PF05978.16 EMD60809.1 - 2.9e-09 36.8 5.8 2.9e-09 36.8 5.8 3.2 2 1 1 3 3 3 1 Ion channel regulatory protein UNC-93 Glucosamine_iso PF01182.20 EMD60810.1 - 3.5e-21 76.1 0.0 5.9e-21 75.4 0.0 1.4 1 1 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase NCA2 PF08637.10 EMD60811.1 - 1.3e-104 349.4 1.0 2.2e-104 348.7 1.0 1.3 1 0 0 1 1 1 1 ATP synthase regulation protein NCA2 TMEM171 PF15471.6 EMD60811.1 - 0.21 10.5 0.1 0.34 9.8 0.1 1.2 1 0 0 1 1 1 0 Transmembrane protein family 171 Ras PF00071.22 EMD60812.1 - 2.5e-64 215.7 0.0 3.1e-64 215.5 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMD60812.1 - 1.1e-33 115.9 0.0 1.8e-33 115.3 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMD60812.1 - 5.7e-13 48.7 0.0 7.1e-13 48.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EMD60812.1 - 1.3e-05 24.9 0.0 2.4e-05 24.0 0.0 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EMD60812.1 - 0.00035 20.0 0.0 0.00044 19.7 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 EMD60812.1 - 0.0033 17.4 0.1 2.7 7.9 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EMD60812.1 - 0.0037 17.3 0.0 0.0069 16.5 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 EMD60812.1 - 0.016 14.7 0.0 0.019 14.4 0.0 1.1 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit FeoB_N PF02421.18 EMD60812.1 - 0.044 13.3 0.0 0.22 11.0 0.0 1.9 1 1 0 1 1 1 0 Ferrous iron transport protein B AAA PF00004.29 EMD60812.1 - 0.093 13.2 0.0 9.3 6.7 0.0 2.2 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) PI3_PI4_kinase PF00454.27 EMD60813.1 - 2.2e-55 188.2 0.0 5.6e-55 186.9 0.0 1.7 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FAT PF02259.23 EMD60813.1 - 3.6e-35 121.8 1.5 7e-35 120.9 1.5 1.5 1 0 0 1 1 1 1 FAT domain UME PF08064.13 EMD60813.1 - 3.3e-31 107.2 0.0 3e-30 104.1 0.0 2.9 1 0 0 1 1 1 1 UME (NUC010) domain FATC PF02260.20 EMD60813.1 - 3.2e-14 52.5 0.0 8.4e-14 51.1 0.0 1.8 1 0 0 1 1 1 1 FATC domain TPR_19 PF14559.6 EMD60813.1 - 0.001 19.5 0.5 0.0082 16.6 0.1 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat DUF3385 PF11865.8 EMD60813.1 - 0.019 14.9 0.0 0.14 12.1 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3385) TPR_14 PF13428.6 EMD60813.1 - 7.6 7.7 9.7 15 6.7 0.1 5.6 6 0 0 6 6 6 0 Tetratricopeptide repeat COX16 PF14138.6 EMD60814.1 - 1.6e-32 111.8 0.3 2.2e-32 111.4 0.3 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein COX16 Synaptobrevin PF00957.21 EMD60815.1 - 0.017 14.9 0.1 0.13 12.1 0.0 2.2 2 1 1 3 3 3 0 Synaptobrevin HMG_CoA_synt_C PF08540.10 EMD60816.1 - 1.7e-104 349.4 0.4 2.2e-104 349.0 0.4 1.1 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal HMG_CoA_synt_N PF01154.17 EMD60816.1 - 2.2e-96 320.7 0.1 3.2e-96 320.2 0.1 1.2 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal MaoC_dehydratas PF01575.19 EMD60817.1 - 2.1e-22 79.0 0.0 4.5e-22 77.9 0.0 1.5 1 0 0 1 1 1 1 MaoC like domain MaoC_dehydrat_N PF13452.6 EMD60817.1 - 6.8e-09 36.0 0.0 4.9e-06 26.7 0.0 2.2 2 0 0 2 2 2 2 N-terminal half of MaoC dehydratase Pkinase PF00069.25 EMD60818.1 - 2.4e-68 230.4 0.0 3.1e-68 230.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD60818.1 - 1.2e-30 106.6 0.0 1.8e-30 106.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 EMD60818.1 - 2e-12 47.6 0.5 2.6e-11 44.0 0.0 2.9 2 1 0 2 2 2 1 Protein kinase C terminal domain Kinase-like PF14531.6 EMD60818.1 - 1.4e-08 34.5 0.1 4.9e-08 32.6 0.0 1.8 2 0 0 2 2 2 1 Kinase-like C2 PF00168.30 EMD60818.1 - 1.1e-06 28.9 0.0 0.00035 20.8 0.0 2.6 2 0 0 2 2 2 1 C2 domain Haspin_kinase PF12330.8 EMD60818.1 - 0.0012 17.8 0.1 0.0021 17.1 0.1 1.4 1 1 0 1 1 1 1 Haspin like kinase domain FTA2 PF13095.6 EMD60818.1 - 0.0015 18.2 0.2 0.39 10.3 0.1 2.4 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 EMD60818.1 - 0.0019 18.2 0.0 0.0033 17.4 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 EMD60818.1 - 0.071 12.5 0.1 0.12 11.7 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Adeno_E3_15_3 PF03307.14 EMD60818.1 - 0.081 12.9 0.0 0.16 12.0 0.0 1.4 1 0 0 1 1 1 0 Adenovirus 15.3kD protein in E3 region CBFD_NFYB_HMF PF00808.23 EMD60819.1 - 9.6e-18 64.2 0.8 1.8e-17 63.4 0.8 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EMD60819.1 - 0.00016 22.0 0.8 0.0011 19.3 0.0 2.0 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 EF-hand_13 PF17958.1 EMD60819.1 - 0.037 13.8 0.0 0.068 13.0 0.0 1.5 1 1 0 1 1 1 0 EF-hand domain Snf7 PF03357.21 EMD60820.1 - 2.2e-07 30.7 15.6 3.5e-07 30.0 14.0 1.8 1 1 1 2 2 2 1 Snf7 Adhesin_P1_N PF18652.1 EMD60820.1 - 0.52 10.4 5.4 14 5.8 0.4 3.1 3 0 0 3 3 3 0 Adhesin P1 N-terminal domain DUF3669 PF12417.8 EMD60821.1 - 3.1e-23 81.8 0.1 6.4e-23 80.7 0.1 1.6 1 0 0 1 1 1 1 Zinc finger protein Ribosomal_S21e PF01249.18 EMD60822.1 - 1.9e-36 124.0 0.0 2.2e-36 123.8 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S21e Sugar_tr PF00083.24 EMD60824.1 - 4.2e-71 240.2 22.7 4.9e-71 239.9 22.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD60824.1 - 2.8e-13 49.5 32.5 6.1e-13 48.4 27.5 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EMD60824.1 - 1.9e-06 26.8 15.5 0.00076 18.1 3.7 2.4 2 0 0 2 2 2 2 MFS/sugar transport protein MFS_1_like PF12832.7 EMD60824.1 - 3e-05 23.1 9.1 0.00011 21.2 3.4 2.2 2 0 0 2 2 2 2 MFS_1 like family Peptidase_M28 PF04389.17 EMD60826.1 - 1.1e-37 129.7 0.3 2e-37 128.8 0.3 1.5 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 EMD60826.1 - 2.4e-13 49.9 0.2 5.1e-13 48.9 0.2 1.6 1 0 0 1 1 1 1 PA domain Peptidase_M20 PF01546.28 EMD60826.1 - 0.00015 21.5 0.1 0.00034 20.4 0.1 1.6 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 TFIIB PF00382.19 EMD60827.1 - 1.9e-31 107.9 1.1 2e-18 66.2 0.1 3.0 2 0 0 2 2 2 2 Transcription factor TFIIB repeat BRF1 PF07741.13 EMD60827.1 - 2.9e-24 85.3 1.7 2.9e-24 85.3 1.7 3.4 3 1 0 3 3 3 1 Brf1-like TBP-binding domain TF_Zn_Ribbon PF08271.12 EMD60827.1 - 0.022 14.2 1.3 0.052 13.1 1.3 1.6 1 0 0 1 1 1 0 TFIIB zinc-binding DDE_Tnp_1_6 PF13751.6 EMD60827.1 - 0.83 9.9 3.0 1.2 9.3 0.2 2.4 2 0 0 2 2 2 0 Transposase DDE domain AT_hook PF02178.19 EMD60827.1 - 4.4 7.5 9.4 13 6.1 9.4 1.8 1 0 0 1 1 1 0 AT hook motif PrmA PF06325.13 EMD60828.1 - 7.5e-11 42.0 0.0 1.6e-10 40.8 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 EMD60828.1 - 1.2e-10 41.9 0.0 3.9e-10 40.3 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMD60828.1 - 2.6e-10 40.3 0.0 4.1e-10 39.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMD60828.1 - 4.1e-07 30.6 0.0 9.8e-07 29.3 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.11 EMD60828.1 - 4.3e-06 25.9 0.1 6.5e-06 25.3 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_18 PF12847.7 EMD60828.1 - 1.8e-05 24.7 0.2 7.1e-05 22.8 0.1 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EMD60828.1 - 2.6e-05 24.1 0.0 4.9e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EMD60828.1 - 0.00017 21.0 0.0 0.00023 20.6 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase MTS PF05175.14 EMD60828.1 - 0.001 18.7 0.0 0.0017 17.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_12 PF08242.12 EMD60828.1 - 0.0026 18.5 0.0 0.0062 17.3 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 EMD60828.1 - 0.019 15.0 0.0 0.033 14.2 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_24 PF13578.6 EMD60828.1 - 0.037 15.0 0.0 0.07 14.2 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain PCMT PF01135.19 EMD60828.1 - 0.14 11.8 0.0 0.31 10.8 0.0 1.5 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Allexi_40kDa PF05549.11 EMD60829.1 - 0.18 11.3 0.7 1.7 8.1 0.0 2.4 2 0 0 2 2 2 0 Allexivirus 40kDa protein Lum_binding PF00677.17 EMD60830.1 - 6.5e-45 151.0 2.3 2.2e-21 75.6 0.6 2.4 2 0 0 2 2 2 2 Lumazine binding domain YabP PF07873.11 EMD60830.1 - 0.027 14.3 0.1 11 5.9 0.0 3.3 3 0 0 3 3 3 0 YabP family CoA_transf_3 PF02515.17 EMD60831.1 - 5.4e-121 404.2 0.5 1.2e-120 403.1 0.0 1.8 2 0 0 2 2 2 1 CoA-transferase family III Kinesin PF00225.23 EMD60831.1 - 2.8e-60 204.0 0.2 4.7e-60 203.3 0.2 1.4 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EMD60831.1 - 5.3e-08 32.9 0.1 2e-05 24.6 0.0 3.0 2 1 0 2 2 2 2 Microtubule binding bZIP_1 PF00170.21 EMD60831.1 - 0.033 14.3 2.6 0.086 12.9 1.0 2.4 2 0 0 2 2 2 0 bZIP transcription factor bZIP_2 PF07716.15 EMD60831.1 - 0.12 12.4 4.4 0.14 12.3 2.5 2.1 2 0 0 2 2 2 0 Basic region leucine zipper DUF4407 PF14362.6 EMD60831.1 - 6.9 5.9 12.4 13 5.0 12.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) PHD PF00628.29 EMD60832.1 - 1.8e-10 40.5 7.5 3e-10 39.8 7.5 1.4 1 0 0 1 1 1 1 PHD-finger zf-PHD-like PF15446.6 EMD60832.1 - 0.00021 20.9 1.7 0.00021 20.9 1.7 1.9 2 0 0 2 2 2 1 PHD/FYVE-zinc-finger like domain Prok-RING_1 PF14446.6 EMD60832.1 - 0.00021 21.1 4.9 0.00043 20.1 4.9 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 1 zf-RRPl_C4 PF17026.5 EMD60832.1 - 0.00052 20.1 2.2 0.00081 19.5 2.2 1.2 1 0 0 1 1 1 1 Putative ribonucleoprotein zinc-finger pf C4 type C1_1 PF00130.22 EMD60832.1 - 0.0015 18.4 2.0 0.0029 17.4 2.0 1.4 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) PSCyt3 PF07627.11 EMD60832.1 - 0.018 15.3 2.8 0.68 10.2 0.0 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1588) PHD_2 PF13831.6 EMD60832.1 - 0.06 12.9 4.5 0.17 11.5 4.5 1.8 1 1 0 1 1 1 0 PHD-finger FYVE_2 PF02318.16 EMD60832.1 - 0.13 12.5 3.5 0.22 11.7 3.5 1.3 1 0 0 1 1 1 0 FYVE-type zinc finger DZR PF12773.7 EMD60832.1 - 0.59 10.2 6.2 1.3 9.1 6.2 1.6 1 0 0 1 1 1 0 Double zinc ribbon GcrA PF07750.11 EMD60832.1 - 1.6 9.1 4.3 0.6 10.5 0.2 2.1 2 0 0 2 2 2 0 GcrA cell cycle regulator RTA1 PF04479.13 EMD60833.1 - 5.3e-74 248.3 5.0 5.3e-74 248.3 5.0 1.4 2 0 0 2 2 2 1 RTA1 like protein COesterase PF00135.28 EMD60834.1 - 7.8e-92 308.8 0.0 9.7e-92 308.5 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EMD60834.1 - 2.8e-06 27.4 0.1 3.4e-05 23.8 0.1 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Esterase PF00756.20 EMD60834.1 - 0.00061 19.5 0.0 0.0012 18.5 0.0 1.4 1 0 0 1 1 1 1 Putative esterase Peptidase_S9 PF00326.21 EMD60834.1 - 0.0019 17.7 0.0 0.0035 16.9 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Aa_trans PF01490.18 EMD60835.1 - 8e-34 117.0 42.2 9.2e-34 116.8 42.2 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein MFS_1 PF07690.16 EMD60836.1 - 2.5e-33 115.5 27.0 7.2e-28 97.5 10.1 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EMD60836.1 - 2.4e-05 23.4 7.3 2.4e-05 23.4 7.3 1.7 2 1 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 EMD60836.1 - 0.0025 16.3 0.4 0.0038 15.7 0.4 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) CFEM PF05730.11 EMD60837.1 - 9.9e-10 38.4 4.8 3.7e-09 36.6 4.8 2.0 1 0 0 1 1 1 1 CFEM domain OATP PF03137.20 EMD60838.1 - 0.057 11.7 0.1 0.087 11.1 0.1 1.2 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family CRAL_TRIO PF00650.20 EMD60839.1 - 1.6e-10 40.9 0.0 2.7e-10 40.2 0.0 1.4 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EMD60839.1 - 0.00019 21.5 0.1 0.00019 21.5 0.1 2.2 2 1 0 2 2 2 1 CRAL/TRIO, N-terminal domain DUF3439 PF11921.8 EMD60839.1 - 0.42 10.6 4.0 0.86 9.6 4.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) SOBP PF15279.6 EMD60839.1 - 1.1 9.8 10.3 1.6 9.3 10.3 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein Dicty_REP PF05086.12 EMD60839.1 - 1.6 6.6 6.5 2.2 6.2 6.5 1.3 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Borrelia_P83 PF05262.11 EMD60839.1 - 4.1 5.8 15.7 6.2 5.2 15.7 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein SDA1 PF05285.12 EMD60839.1 - 6.6 6.1 23.5 9.5 5.5 23.5 1.1 1 0 0 1 1 1 0 SDA1 WTX PF09422.10 EMD60839.1 - 6.9 5.6 21.6 10 5.0 21.6 1.2 1 0 0 1 1 1 0 WTX protein Hid1 PF12722.7 EMD60839.1 - 9.4 4.2 11.2 11 4.0 11.2 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein RRM_1 PF00076.22 EMD60840.1 - 0.0013 18.5 0.0 0.0023 17.7 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Btz PF09405.10 EMD60840.1 - 0.025 14.8 0.1 0.048 13.9 0.1 1.4 1 0 0 1 1 1 0 CASC3/Barentsz eIF4AIII binding FGGY_C PF02782.16 EMD60841.1 - 6.8e-51 172.8 0.2 1.1e-50 172.1 0.2 1.3 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 EMD60841.1 - 4.7e-25 88.6 0.3 1.8e-23 83.4 0.3 2.8 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain BcrAD_BadFG PF01869.20 EMD60841.1 - 0.00065 19.3 0.1 0.0022 17.5 0.0 2.0 2 0 0 2 2 2 1 BadF/BadG/BcrA/BcrD ATPase family E3_binding PF02817.17 EMD60841.1 - 0.064 13.6 0.0 0.5 10.8 0.0 2.3 2 0 0 2 2 2 0 e3 binding domain zf-C2H2_9 PF16293.5 EMD60841.1 - 0.085 12.7 0.1 0.29 11.0 0.1 1.9 1 0 0 1 1 1 0 C2H2 type zinc-finger (1 copy) DEDD_Tnp_IS110 PF01548.17 EMD60841.1 - 0.23 11.3 0.5 0.89 9.4 0.1 2.1 2 0 0 2 2 2 0 Transposase dCMP_cyt_deam_1 PF00383.23 EMD60843.1 - 2.5e-24 85.1 0.1 3.5e-24 84.6 0.1 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EMD60843.1 - 7.2e-19 67.9 0.0 1e-18 67.4 0.0 1.2 1 0 0 1 1 1 1 MafB19-like deaminase Bd3614-deam PF14439.6 EMD60843.1 - 0.002 18.2 0.4 0.033 14.3 0.2 2.1 1 1 1 2 2 2 1 Bd3614-like deaminase APOBEC4_like PF18774.1 EMD60843.1 - 0.035 14.0 0.0 0.053 13.5 0.0 1.2 1 0 0 1 1 1 0 APOBEC4-like -AID/APOBEC-deaminase APOBEC3 PF18771.1 EMD60843.1 - 0.043 13.9 0.0 0.066 13.3 0.0 1.3 1 0 0 1 1 1 0 APOBEC3 SNAD4 PF18750.1 EMD60843.1 - 0.1 12.7 0.0 0.18 11.9 0.0 1.3 1 0 0 1 1 1 0 Secreted Novel AID/APOBEC-like Deaminase 4 Cg6151-P PF10233.9 EMD60844.1 - 1.6e-44 150.8 16.8 1.9e-44 150.6 16.8 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein CG6151-P Phage_holin_3_6 PF07332.11 EMD60844.1 - 0.067 13.2 10.2 0.22 11.6 3.2 2.1 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III DUF5592 PF17332.2 EMD60844.1 - 0.099 13.2 1.1 0.099 13.2 1.1 2.2 2 1 0 2 2 2 0 Family of unknown function (DUF5592) Cytochrom_B558a PF05038.13 EMD60844.1 - 0.19 11.3 2.0 0.91 9.1 0.1 2.3 2 1 0 2 2 2 0 Cytochrome Cytochrome b558 alpha-subunit DUF2721 PF11026.8 EMD60844.1 - 5.1 7.0 15.0 1.1 9.1 5.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) DUF2070 PF09843.9 EMD60844.1 - 9.5 4.4 10.5 11 4.2 10.5 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Aim21 PF11489.8 EMD60845.1 - 2.4e-216 721.0 62.5 2.4e-216 721.0 62.5 2.8 3 0 0 3 3 3 1 Altered inheritance of mitochondria protein 21 TPR_10 PF13374.6 EMD60846.1 - 2.6e-27 93.9 1.8 9.5e-06 25.3 0.1 5.8 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_12 PF13424.6 EMD60846.1 - 1.6e-23 82.8 4.5 1.5e-09 38.0 0.1 4.4 2 1 1 4 4 4 3 Tetratricopeptide repeat NB-ARC PF00931.22 EMD60846.1 - 4.4e-13 49.0 0.0 7.5e-13 48.3 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain ANAPC3 PF12895.7 EMD60846.1 - 1.4e-11 44.4 0.6 0.00051 20.2 0.0 3.9 1 1 1 3 3 3 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 EMD60846.1 - 3e-08 34.1 6.5 0.022 15.3 0.3 5.4 2 1 2 5 5 5 2 Tetratricopeptide repeat TPR_6 PF13174.6 EMD60846.1 - 1.9e-07 31.3 0.6 0.04 14.5 0.1 4.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.17 EMD60846.1 - 2e-07 30.6 1.7 0.18 12.0 0.0 4.9 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.6 EMD60846.1 - 1.1e-05 25.1 2.1 16 5.8 0.0 6.0 6 0 0 6 6 6 0 Tetratricopeptide repeat AAA_16 PF13191.6 EMD60846.1 - 1.6e-05 25.4 1.2 0.00013 22.4 0.1 2.8 1 1 0 2 2 2 1 AAA ATPase domain TPR_14 PF13428.6 EMD60846.1 - 0.00047 20.8 4.1 0.91 10.5 0.3 4.8 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.6 EMD60846.1 - 0.00084 19.4 3.6 1 9.8 0.0 5.1 6 0 0 6 6 4 1 Tetratricopeptide repeat AAA_22 PF13401.6 EMD60846.1 - 0.003 17.9 0.2 0.017 15.4 0.0 2.2 2 0 0 2 2 2 1 AAA domain SPO22 PF08631.10 EMD60846.1 - 0.0044 16.6 0.5 0.027 14.0 0.2 2.5 1 1 0 1 1 1 1 Meiosis protein SPO22/ZIP4 like TPR_20 PF14561.6 EMD60846.1 - 0.0049 17.2 8.7 2.6 8.5 0.0 4.4 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_4 PF07721.14 EMD60846.1 - 0.0052 17.3 9.4 0.24 12.1 0.0 5.1 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_1 PF00515.28 EMD60846.1 - 0.045 13.6 6.8 8.3 6.4 0.0 4.6 6 0 0 6 6 5 0 Tetratricopeptide repeat CODH_A_N PF18537.1 EMD60846.1 - 0.052 13.6 0.0 11 6.2 0.0 2.8 2 0 0 2 2 2 0 Carbon monoxide dehydrogenase subunit alpha N-terminal domain ATP13 PF12921.7 EMD60846.1 - 0.085 12.7 0.0 29 4.6 0.0 3.3 1 1 2 3 3 3 0 Mitochondrial ATPase expression TPR_16 PF13432.6 EMD60846.1 - 0.1 13.3 7.0 2.5 8.8 0.1 4.8 4 1 1 5 5 5 0 Tetratricopeptide repeat ATPase_2 PF01637.18 EMD60846.1 - 0.11 12.4 0.0 0.24 11.3 0.0 1.6 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea FAD_binding_4 PF01565.23 EMD60847.1 - 5.3e-23 81.3 0.6 1.1e-22 80.3 0.6 1.5 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EMD60847.1 - 0.14 12.3 0.0 0.29 11.3 0.0 1.6 1 0 0 1 1 1 0 Berberine and berberine like Polysacc_deac_1 PF01522.21 EMD60849.1 - 4.7e-28 97.6 0.0 9.1e-28 96.7 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide deacetylase Chitin_bind_1 PF00187.19 EMD60849.1 - 1.2e-16 60.8 76.7 7.9e-06 26.2 17.5 4.1 3 1 0 3 3 3 3 Chitin recognition protein DUF2334 PF10096.9 EMD60849.1 - 0.0037 16.9 0.0 0.0061 16.2 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2334) Pkinase PF00069.25 EMD60850.1 - 1.5e-67 227.8 0.0 2e-67 227.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD60850.1 - 1.1e-29 103.5 0.0 1.6e-29 103.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMD60850.1 - 0.0086 15.4 0.0 0.11 11.8 0.0 2.2 2 1 0 2 2 2 1 Kinase-like Pkinase_C PF00433.24 EMD60850.1 - 0.059 14.1 3.4 0.18 12.5 3.4 1.9 1 0 0 1 1 1 0 Protein kinase C terminal domain RRM_1 PF00076.22 EMD60851.1 - 2.1e-09 37.1 0.0 5.3e-09 35.8 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EMD60851.1 - 6.1e-05 22.8 0.1 0.00012 21.8 0.1 1.5 1 0 0 1 1 1 1 Occluded RNA-recognition motif RRM_3 PF08777.11 EMD60851.1 - 0.016 15.3 0.1 0.047 13.7 0.1 1.9 1 1 0 1 1 1 0 RNA binding motif Nup35_RRM_2 PF14605.6 EMD60851.1 - 0.026 14.5 0.0 0.083 12.9 0.0 1.9 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif USP8_dimer PF08969.11 EMD60851.1 - 0.096 12.9 0.8 0.2 11.8 0.8 1.6 1 0 0 1 1 1 0 USP8 dimerisation domain ADH_zinc_N PF00107.26 EMD60852.1 - 2.3e-14 53.5 0.0 3.7e-14 52.8 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EMD60852.1 - 0.03 14.2 0.0 0.11 12.4 0.0 1.9 2 0 0 2 2 2 0 Alcohol dehydrogenase GroES-like domain MRJP PF03022.16 EMD60853.1 - 4.6e-32 111.5 0.0 1.1e-31 110.3 0.0 1.5 1 1 0 1 1 1 1 Major royal jelly protein SGL PF08450.12 EMD60853.1 - 0.011 15.3 0.0 0.058 13.0 0.0 2.0 2 1 0 2 2 2 0 SMP-30/Gluconolactonase/LRE-like region Med17 PF10156.9 EMD60854.1 - 2.9e-100 336.2 0.6 4e-100 335.7 0.6 1.1 1 0 0 1 1 1 1 Subunit 17 of Mediator complex SOAR PF16533.5 EMD60854.1 - 0.77 9.8 4.3 0.58 10.2 1.3 2.4 2 0 0 2 2 2 0 STIM1 Orai1-activating region ISN1 PF06437.11 EMD60855.1 - 8.9e-190 630.9 0.0 1e-189 630.7 0.0 1.0 1 0 0 1 1 1 1 IMP-specific 5'-nucleotidase WD40 PF00400.32 EMD60859.1 - 5e-05 24.0 4.6 0.14 13.1 0.3 5.1 5 0 0 5 5 5 1 WD domain, G-beta repeat DUF5018 PF16410.5 EMD60859.1 - 0.071 11.8 0.0 0.12 11.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5018) RNA_pol_N PF01194.17 EMD60860.1 - 1.1e-29 102.5 0.6 1.3e-29 102.2 0.6 1.1 1 0 0 1 1 1 1 RNA polymerases N / 8 kDa subunit Chordopox_RPO7 PF05864.12 EMD60860.1 - 0.041 14.1 0.2 0.052 13.8 0.2 1.2 1 0 0 1 1 1 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) Metallophos PF00149.28 EMD60861.1 - 2.8e-09 37.8 2.3 2.8e-09 37.8 2.3 1.6 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase 5_nucleotid_C PF02872.18 EMD60861.1 - 0.086 13.1 0.0 0.17 12.1 0.0 1.5 1 0 0 1 1 1 0 5'-nucleotidase, C-terminal domain RCC1 PF00415.18 EMD60862.1 - 9.1e-58 192.7 3.8 2e-08 34.7 0.0 7.8 7 1 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EMD60862.1 - 8.9e-37 124.2 25.3 6.1e-08 32.3 1.6 6.4 6 0 0 6 6 6 6 Regulator of chromosome condensation (RCC1) repeat sCache_3_2 PF17203.4 EMD60862.1 - 0.013 15.6 0.1 0.4 10.8 0.0 2.6 3 0 0 3 3 3 0 Single cache domain 3 Ribosomal_L13 PF00572.18 EMD60863.1 - 4.4e-41 140.0 0.0 6e-41 139.6 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L13 HMA PF00403.26 EMD60864.1 - 7.1e-15 55.2 0.0 1.1e-14 54.6 0.0 1.3 1 0 0 1 1 1 1 Heavy-metal-associated domain Sod_Cu PF00080.20 EMD60864.1 - 1.3e-09 38.4 0.0 2e-09 37.7 0.0 1.3 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) PIN_2 PF10130.9 EMD60864.1 - 0.099 12.9 0.1 0.32 11.2 0.1 1.8 2 0 0 2 2 2 0 PIN domain TPR_1 PF00515.28 EMD60865.1 - 5.3e-14 51.4 5.4 5.9e-07 29.0 0.0 4.0 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 EMD60865.1 - 1.7e-13 49.5 5.8 2e-05 24.3 0.0 4.8 5 0 0 5 5 4 3 Tetratricopeptide repeat TPR_12 PF13424.6 EMD60865.1 - 6.5e-10 39.2 0.0 6.1e-06 26.4 0.0 3.2 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 EMD60865.1 - 8.2e-08 31.9 3.3 0.00023 21.1 0.0 4.1 5 0 0 5 5 4 1 Tetratricopeptide repeat PB1 PF00564.24 EMD60865.1 - 2.4e-07 30.6 0.3 4.8e-07 29.6 0.3 1.4 1 0 0 1 1 1 1 PB1 domain TPR_7 PF13176.6 EMD60865.1 - 4.1e-07 29.6 0.2 4.7e-05 23.1 0.0 3.7 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 EMD60865.1 - 2e-06 27.4 0.5 3.2e-05 23.5 0.1 3.0 2 1 1 3 3 3 1 TPR repeat TPR_6 PF13174.6 EMD60865.1 - 6e-06 26.6 1.8 1.6 9.6 0.0 4.5 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_9 PF13371.6 EMD60865.1 - 0.00012 22.1 0.3 0.16 12.2 0.1 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.6 EMD60865.1 - 0.0018 18.9 0.4 0.19 12.4 0.1 3.2 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 EMD60865.1 - 0.0076 17.0 0.4 0.58 11.1 0.1 3.6 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_10 PF13374.6 EMD60865.1 - 0.074 12.9 0.5 2.7 8.0 0.0 3.6 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_17 PF13431.6 EMD60865.1 - 0.14 12.6 0.5 3.2 8.4 0.0 3.2 4 0 0 4 4 3 0 Tetratricopeptide repeat Tom6 PF17112.5 EMD60866.1 - 3.9e-05 23.1 0.0 4.4e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial import receptor subunit Tom6, fungal Matrix PF00661.21 EMD60866.1 - 0.1 11.3 0.0 0.1 11.3 0.0 1.0 1 0 0 1 1 1 0 Viral matrix protein Uricase PF01014.18 EMD60867.1 - 1.2e-77 258.5 0.7 1.9e-42 144.6 0.4 2.0 2 0 0 2 2 2 2 Uricase RICTOR_N PF14664.6 EMD60868.1 - 1.3e-128 429.1 2.8 2.4e-128 428.3 0.4 2.6 3 1 1 4 4 4 1 Rapamycin-insensitive companion of mTOR, N-term RasGEF_N_2 PF14663.6 EMD60868.1 - 4e-41 139.8 0.0 1.9e-36 124.7 0.0 3.7 3 0 0 3 3 3 2 Rapamycin-insensitive companion of mTOR RasGEF_N domain RICTOR_M PF14666.6 EMD60868.1 - 9.9e-37 124.9 0.4 9.2e-34 115.4 0.2 4.3 4 0 0 4 4 4 1 Rapamycin-insensitive companion of mTOR, middle domain RICTOR_V PF14668.6 EMD60868.1 - 2.9e-29 101.1 1.6 1.8e-28 98.6 0.2 3.1 4 0 0 4 4 4 1 Rapamycin-insensitive companion of mTOR, domain 5 HR1 PF02185.16 EMD60868.1 - 1.6e-09 37.8 14.9 3.7e-09 36.5 14.9 1.7 1 0 0 1 1 1 1 Hr1 repeat LON_substr_bdg PF02190.16 EMD60869.1 - 3.2e-29 102.3 0.0 4.5e-29 101.8 0.0 1.2 1 0 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain zf-C3HC4_2 PF13923.6 EMD60869.1 - 2.2e-14 53.0 19.0 4.2e-10 39.3 9.8 2.8 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EMD60869.1 - 2.1e-13 50.2 18.1 8e-07 29.1 5.6 3.0 2 1 1 3 3 3 2 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 EMD60869.1 - 9.8e-13 47.9 22.6 3.7e-07 30.1 4.7 3.1 3 1 0 3 3 2 2 RING-type zinc-finger zf-RING_5 PF14634.6 EMD60869.1 - 5.1e-11 42.4 18.0 3.2e-06 27.0 8.2 2.6 2 0 0 2 2 2 2 zinc-RING finger domain zf-C3HC4 PF00097.25 EMD60869.1 - 3.4e-10 39.6 18.0 2.5e-05 24.0 9.0 2.6 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EMD60869.1 - 4e-10 39.4 17.7 1.5e-06 27.9 7.5 2.5 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EMD60869.1 - 1.2e-09 38.3 22.0 3.2e-07 30.6 9.3 2.9 2 1 0 2 2 2 2 Ring finger domain Prok-RING_4 PF14447.6 EMD60869.1 - 1.9e-09 37.3 17.4 6.4e-06 25.9 8.1 2.7 2 0 0 2 2 2 2 Prokaryotic RING finger family 4 zf-RING_10 PF16685.5 EMD60869.1 - 8.9e-07 29.0 16.5 4e-06 26.9 4.2 2.5 2 0 0 2 2 2 2 zinc RING finger of MSL2 zf-RING_6 PF14835.6 EMD60869.1 - 0.0017 18.2 11.0 0.075 12.9 2.5 2.5 2 0 0 2 2 2 2 zf-RING of BARD1-type protein U-box PF04564.15 EMD60869.1 - 0.0042 17.2 0.2 0.027 14.6 0.0 2.2 2 0 0 2 2 2 1 U-box domain zf-RING_4 PF14570.6 EMD60869.1 - 0.014 15.1 6.3 0.014 15.1 6.3 3.7 3 1 0 3 3 3 0 RING/Ubox like zinc-binding domain Slp PF03843.13 EMD60869.1 - 0.025 14.0 0.0 0.047 13.1 0.0 1.4 1 0 0 1 1 1 0 Outer membrane lipoprotein Slp family zf-rbx1 PF12678.7 EMD60869.1 - 0.11 12.8 12.7 0.093 13.0 6.6 2.7 2 0 0 2 2 2 0 RING-H2 zinc finger domain zinc-ribbons_6 PF07191.12 EMD60869.1 - 7.3 6.7 11.3 7.3 6.6 2.4 2.7 2 1 0 2 2 2 0 zinc-ribbons DZR PF12773.7 EMD60869.1 - 8.2 6.6 15.6 23 5.1 1.2 3.1 2 1 2 4 4 4 0 Double zinc ribbon SesA PF17107.5 EMD60870.1 - 2.3e-08 34.2 0.2 3.7e-08 33.6 0.2 1.4 1 1 0 1 1 1 1 N-terminal domain on NACHT_NTPase and P-loop NTPases Helo_like_N PF17111.5 EMD60870.1 - 2.8e-05 23.6 0.2 3.3e-05 23.4 0.2 1.1 1 0 0 1 1 1 1 Fungal N-terminal domain of STAND proteins CorA PF01544.18 EMD60870.1 - 0.0013 18.1 0.0 0.047 13.0 0.3 2.0 2 0 0 2 2 2 1 CorA-like Mg2+ transporter protein RPW8 PF05659.11 EMD60870.1 - 0.0014 18.4 1.6 0.0043 16.8 0.7 1.9 1 1 1 2 2 2 1 Arabidopsis broad-spectrum mildew resistance protein RPW8 COG2 PF06148.11 EMD60870.1 - 0.0057 16.7 0.4 0.0097 16.0 0.4 1.3 1 0 0 1 1 1 1 COG (conserved oligomeric Golgi) complex component, COG2 Lebercilin PF15619.6 EMD60870.1 - 0.023 14.3 1.0 0.046 13.4 1.0 1.4 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease DUF3232 PF11554.8 EMD60870.1 - 0.027 14.8 0.0 0.22 11.9 0.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3232) Allexi_40kDa PF05549.11 EMD60870.1 - 0.062 12.8 0.2 0.073 12.6 0.2 1.2 1 0 0 1 1 1 0 Allexivirus 40kDa protein DAO PF01266.24 EMD60872.1 - 5.6e-52 177.5 0.8 6.4e-52 177.3 0.8 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 EMD60872.1 - 8e-05 23.1 0.0 0.48 11.0 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EMD60872.1 - 0.0002 20.7 0.0 0.48 9.6 0.0 2.8 2 1 1 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EMD60872.1 - 0.00028 20.3 0.0 0.29 10.4 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain MCRA PF06100.11 EMD60872.1 - 0.00069 18.5 0.1 0.00095 18.1 0.1 1.1 1 0 0 1 1 1 1 MCRA family NAD_binding_8 PF13450.6 EMD60872.1 - 0.0023 18.1 0.0 0.0054 16.9 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain ApbA PF02558.16 EMD60872.1 - 0.028 14.1 0.1 0.093 12.4 0.0 1.9 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA Trp_halogenase PF04820.14 EMD60872.1 - 0.035 13.0 0.0 6.2 5.6 0.0 2.1 2 0 0 2 2 2 0 Tryptophan halogenase ChpA-C PF03777.13 EMD60872.1 - 0.13 12.2 0.1 0.32 10.9 0.1 1.7 1 0 0 1 1 1 0 ChpA-C Rossmann-like PF10727.9 EMD60872.1 - 0.13 12.1 0.1 8.5 6.3 0.0 2.8 2 1 1 3 3 3 0 Rossmann-like domain Sacchrp_dh_NADP PF03435.18 EMD60872.1 - 0.18 12.1 0.0 0.35 11.1 0.0 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain CRC_subunit PF08624.10 EMD60874.1 - 1.8e-52 177.4 0.1 2.5e-52 176.9 0.1 1.2 1 0 0 1 1 1 1 Chromatin remodelling complex Rsc7/Swp82 subunit DUF5050 PF16472.5 EMD60874.1 - 0.058 12.6 0.0 0.086 12.1 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5050) bZIP_1 PF00170.21 EMD60876.1 - 1.4e-06 28.3 15.1 2.2e-06 27.7 15.1 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EMD60876.1 - 0.00021 21.3 20.4 0.00036 20.5 20.4 1.4 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 EMD60876.1 - 0.0014 19.1 10.5 0.0025 18.3 10.5 1.3 1 0 0 1 1 1 1 bZIP Maf transcription factor Taxilin PF09728.9 EMD60876.1 - 0.0023 17.2 4.8 0.0032 16.7 4.8 1.1 1 0 0 1 1 1 1 Myosin-like coiled-coil protein Spc7 PF08317.11 EMD60876.1 - 0.005 15.8 0.8 0.0085 15.0 0.8 1.3 1 0 0 1 1 1 1 Spc7 kinetochore protein APG6_N PF17675.1 EMD60876.1 - 0.056 14.0 5.6 0.09 13.3 5.6 1.2 1 0 0 1 1 1 0 Apg6 coiled-coil region FapA PF03961.13 EMD60876.1 - 1.2 7.6 2.9 1.7 7.2 2.9 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A Pox_G5 PF04599.12 EMD60876.1 - 3.9 6.4 6.8 5.4 5.9 6.8 1.1 1 0 0 1 1 1 0 Poxvirus G5 protein CENP-H PF05837.12 EMD60876.1 - 7.9 6.9 9.2 13 6.2 9.2 1.3 1 0 0 1 1 1 0 Centromere protein H (CENP-H) DUF3704 PF12488.8 EMD60877.1 - 0.29 10.8 2.4 3 7.6 0.1 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF3704) HET PF06985.11 EMD60878.1 - 9.3e-23 81.2 0.0 3.3e-22 79.4 0.0 1.9 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Utp21 PF04192.12 EMD60879.1 - 3.4e-76 255.8 0.0 5e-76 255.3 0.0 1.2 1 0 0 1 1 1 1 Utp21 specific WD40 associated putative domain ANAPC4_WD40 PF12894.7 EMD60879.1 - 2.8e-18 66.0 0.0 3.6e-05 24.0 0.0 6.5 3 2 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EMD60879.1 - 3.9e-16 59.1 38.1 0.0011 19.7 0.0 11.5 12 2 0 12 12 12 5 WD domain, G-beta repeat Cytochrom_D1 PF02239.16 EMD60879.1 - 0.00028 19.5 0.0 0.00069 18.2 0.0 1.6 1 1 0 1 1 1 1 Cytochrome D1 heme domain Nucleoporin_N PF08801.11 EMD60879.1 - 0.0062 15.3 0.0 0.46 9.2 0.0 2.6 1 1 0 2 2 2 1 Nup133 N terminal like Nup160 PF11715.8 EMD60879.1 - 0.012 14.3 0.1 4.5 5.8 0.1 3.5 2 1 1 3 3 3 0 Nucleoporin Nup120/160 DUF5046 PF16465.5 EMD60879.1 - 0.026 14.0 0.0 1.6 8.1 0.0 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF5046) PALB2_WD40 PF16756.5 EMD60879.1 - 0.11 11.4 0.0 40 3.0 0.0 3.4 3 1 0 3 3 3 0 Partner and localizer of BRCA2 WD40 domain Lgl_C PF08596.10 EMD60879.1 - 0.14 10.9 0.0 9.1 4.9 0.0 2.2 2 0 0 2 2 2 0 Lethal giant larvae(Lgl) like, C-terminal His_Phos_2 PF00328.22 EMD60880.1 - 5.3e-107 358.5 0.3 7e-107 358.1 0.3 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) PPIP5K2_N PF18086.1 EMD60880.1 - 2.7e-34 117.2 0.0 5.5e-34 116.2 0.0 1.5 1 0 0 1 1 1 1 Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain RimK PF08443.11 EMD60880.1 - 7.1e-05 22.5 0.0 0.00012 21.7 0.0 1.3 1 0 0 1 1 1 1 RimK-like ATP-grasp domain Glyco_hydro_3_C PF01915.22 EMD60881.1 - 4.4e-47 160.7 0.0 7.5e-47 159.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 EMD60881.1 - 3.5e-35 121.9 0.0 5.5e-35 121.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 EMD60881.1 - 1.1e-22 79.9 0.1 2e-22 79.1 0.1 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain BUD22 PF09073.10 EMD60883.1 - 0.15 11.4 10.4 0.16 11.3 10.4 1.1 1 0 0 1 1 1 0 BUD22 SURF2 PF05477.11 EMD60883.1 - 0.61 9.7 6.3 0.85 9.3 6.3 1.2 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) SDA1 PF05285.12 EMD60883.1 - 0.83 9.0 12.5 1.1 8.6 12.5 1.2 1 0 0 1 1 1 0 SDA1 DNA_pol_phi PF04931.13 EMD60883.1 - 4.6 5.2 21.1 6.1 4.8 21.1 1.1 1 0 0 1 1 1 0 DNA polymerase phi Ndc80_HEC PF03801.13 EMD60885.1 - 1.8e-55 186.7 1.2 1.8e-55 186.7 1.2 1.7 2 0 0 2 2 2 1 HEC/Ndc80p family TraF_2 PF13729.6 EMD60885.1 - 0.19 11.1 3.4 1 8.7 0.3 2.6 2 0 0 2 2 2 0 F plasmid transfer operon, TraF, protein NPV_P10 PF05531.12 EMD60885.1 - 0.34 11.4 12.6 1.7 9.2 0.7 4.9 2 2 1 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF1759 PF03564.15 EMD60885.1 - 1 9.3 7.8 0.2 11.6 2.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1759) Tweety PF04906.13 EMD60885.1 - 1.6 7.3 4.0 2.6 6.6 0.1 2.4 2 0 0 2 2 2 0 Tweety DUF4094 PF13334.6 EMD60885.1 - 6.4 7.3 11.5 19 5.8 2.1 3.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4094) FAR1 PF03101.15 EMD60886.1 - 8.8e-08 32.7 1.1 1.8e-07 31.8 1.1 1.5 1 0 0 1 1 1 1 FAR1 DNA-binding domain Vma12 PF11712.8 EMD60886.1 - 0.17 12.0 0.0 0.43 10.6 0.0 1.6 1 0 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase p450 PF00067.22 EMD60887.1 - 4e-49 167.6 0.0 5.2e-49 167.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Methyltransf_23 PF13489.6 EMD60888.1 - 5.1e-18 65.5 0.0 7.3e-18 64.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMD60888.1 - 1.4e-09 37.9 0.0 5.9e-09 35.9 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMD60888.1 - 5.9e-08 33.3 0.0 1.2e-07 32.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMD60888.1 - 1.7e-05 25.4 0.0 3.6e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMD60888.1 - 3.7e-05 24.4 0.0 0.00017 22.3 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EMD60888.1 - 0.00036 20.1 0.0 0.00057 19.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain FtsJ PF01728.19 EMD60888.1 - 0.00089 19.4 0.0 0.0013 18.9 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_4 PF02390.17 EMD60888.1 - 0.001 18.5 0.0 0.0021 17.5 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase CMAS PF02353.20 EMD60888.1 - 0.005 16.2 0.0 0.014 14.7 0.0 1.7 2 0 0 2 2 2 1 Mycolic acid cyclopropane synthetase Methyltransf_9 PF08003.11 EMD60888.1 - 0.018 14.0 0.0 0.037 12.9 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1698) AdoMet_MTase PF07757.13 EMD60888.1 - 0.024 15.0 0.1 5.5 7.4 0.0 2.3 2 0 0 2 2 2 0 Predicted AdoMet-dependent methyltransferase Ubie_methyltran PF01209.18 EMD60888.1 - 0.14 11.5 0.0 1.1 8.5 0.0 2.2 2 1 0 2 2 2 0 ubiE/COQ5 methyltransferase family Baculo_PEP_C PF04513.12 EMD60889.1 - 0.038 14.0 1.0 0.22 11.6 0.6 2.2 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Het-C PF07217.11 EMD60889.1 - 0.11 11.0 0.1 0.16 10.5 0.1 1.1 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C DUF3292 PF11696.8 EMD60890.1 - 4e-297 987.0 0.0 4.6e-297 986.8 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3292) Kelch_1 PF01344.25 EMD60892.1 - 5.8e-25 86.6 6.3 1.4e-09 37.4 0.4 5.7 5 0 0 5 5 5 4 Kelch motif Kelch_6 PF13964.6 EMD60892.1 - 2.2e-24 84.9 3.2 4.9e-09 36.1 0.1 5.6 4 1 1 5 5 5 4 Kelch motif Kelch_4 PF13418.6 EMD60892.1 - 3.2e-23 81.5 10.2 5.1e-06 26.4 0.2 6.3 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_3 PF13415.6 EMD60892.1 - 3.5e-22 78.2 6.6 2.1e-06 27.8 0.5 6.6 6 1 0 6 6 6 4 Galactose oxidase, central domain Kelch_5 PF13854.6 EMD60892.1 - 5.1e-19 67.8 6.8 0.00073 19.5 0.0 6.5 7 0 0 7 7 7 4 Kelch motif Kelch_2 PF07646.15 EMD60892.1 - 1.2e-10 41.0 10.1 0.0015 18.4 0.2 6.0 7 0 0 7 7 7 3 Kelch motif ABC1 PF03109.16 EMD60893.1 - 1.3e-21 76.9 0.0 7.4e-12 45.5 0.0 2.5 1 1 1 2 2 2 2 ABC1 family Raf1_HTH PF18579.1 EMD60893.1 - 0.049 13.3 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 Rubisco accumulation factor 1 helix turn helix domain POTRA_TamA_1 PF17243.2 EMD60893.1 - 0.094 12.8 0.0 0.45 10.6 0.0 2.1 2 0 0 2 2 2 0 POTRA domain TamA domain 1 RIO1 PF01163.22 EMD60893.1 - 0.097 12.3 0.0 0.39 10.3 0.0 1.9 2 0 0 2 2 2 0 RIO1 family Pyr_redox_2 PF07992.14 EMD60894.1 - 1.7e-18 66.9 0.0 2.4e-16 59.8 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 EMD60894.1 - 7.4e-16 57.7 0.1 8.7e-14 50.8 0.0 2.1 2 0 0 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EMD60894.1 - 4e-13 49.3 0.0 3.9e-12 46.1 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EMD60894.1 - 3.5e-10 39.6 0.0 3.7e-09 36.2 0.0 2.4 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 EMD60894.1 - 2e-08 34.3 0.0 7.1e-07 29.4 0.0 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 EMD60894.1 - 4.5e-05 23.5 0.2 5.3 7.0 0.0 4.1 4 0 0 4 4 4 1 FAD-NAD(P)-binding Lycopene_cycl PF05834.12 EMD60894.1 - 7.8e-05 21.9 0.0 0.0067 15.5 0.0 2.4 2 0 0 2 2 2 1 Lycopene cyclase protein Pyr_redox PF00070.27 EMD60894.1 - 0.00011 22.7 0.2 0.036 14.6 0.0 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EMD60894.1 - 0.00061 19.1 0.2 0.0074 15.6 0.0 2.1 2 0 0 2 2 2 1 Thi4 family FAD_binding_2 PF00890.24 EMD60894.1 - 0.0025 17.0 0.0 0.005 16.0 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain FAD_binding_3 PF01494.19 EMD60894.1 - 0.0039 16.5 0.1 0.04 13.2 0.0 2.5 3 0 0 3 3 3 1 FAD binding domain HI0933_like PF03486.14 EMD60894.1 - 0.038 12.7 0.5 3.2 6.4 0.2 3.0 3 0 0 3 3 3 0 HI0933-like protein Shikimate_DH PF01488.20 EMD60894.1 - 0.061 13.4 0.3 1.9 8.6 0.0 2.4 3 0 0 3 3 2 0 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.19 EMD60894.1 - 0.061 12.7 0.0 0.15 11.4 0.0 1.6 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_Gly3P_dh_N PF01210.23 EMD60894.1 - 0.12 12.3 0.0 0.21 11.5 0.0 1.3 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_binding_7 PF13241.6 EMD60894.1 - 0.13 12.7 0.0 1.4 9.4 0.0 2.4 2 0 0 2 2 2 0 Putative NAD(P)-binding DAO PF01266.24 EMD60894.1 - 0.59 9.7 2.4 4.1 6.9 0.1 2.9 3 1 1 4 4 4 0 FAD dependent oxidoreductase CAP59_mtransfer PF11735.8 EMD60895.1 - 5e-65 219.6 0.0 6.2e-65 219.2 0.0 1.1 1 0 0 1 1 1 1 Cryptococcal mannosyltransferase 1 SNARE PF05739.19 EMD60895.1 - 0.34 10.9 0.6 0.68 10.0 0.6 1.5 1 0 0 1 1 1 0 SNARE domain TMEM154 PF15102.6 EMD60896.1 - 0.00028 20.8 0.0 0.0004 20.3 0.0 1.2 1 0 0 1 1 1 1 TMEM154 protein family SKG6 PF08693.10 EMD60896.1 - 0.0029 17.0 5.3 0.0062 15.9 5.3 1.6 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Protocadherin PF08374.11 EMD60896.1 - 0.024 14.6 0.8 0.034 14.1 0.4 1.4 1 1 0 1 1 1 0 Protocadherin RAP1 PF07218.11 EMD60896.1 - 0.029 12.7 9.7 0.035 12.4 9.7 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) EphA2_TM PF14575.6 EMD60896.1 - 0.039 14.8 0.0 0.072 14.0 0.0 1.4 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Trp_oprn_chp PF09534.10 EMD60896.1 - 0.06 13.2 0.6 0.1 12.4 0.6 1.3 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) HOK_GEF PF01848.16 EMD60896.1 - 0.072 12.5 3.8 0.16 11.4 3.8 1.5 1 0 0 1 1 1 0 Hok/gef family TrbL PF04610.14 EMD60896.1 - 0.12 12.1 0.2 0.17 11.6 0.2 1.1 1 0 0 1 1 1 0 TrbL/VirB6 plasmid conjugal transfer protein BES1_N PF05687.13 EMD60896.1 - 2.2 8.7 6.4 4 7.8 6.4 1.4 1 0 0 1 1 1 0 BES1/BZR1 plant transcription factor, N-terminal DUF515 PF04415.12 EMD60896.1 - 4.8 5.5 8.8 7.2 4.9 8.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF515) DUF2458 PF10454.9 EMD60897.1 - 7.7e-53 178.7 0.0 1e-52 178.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2458) MRP-S27 PF10037.9 EMD60897.1 - 0.028 13.3 0.5 0.057 12.3 0.5 1.4 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S27 DGCR6 PF07324.11 EMD60897.1 - 0.064 12.9 0.2 0.17 11.5 0.2 1.6 1 1 0 1 1 1 0 DiGeorge syndrome critical region 6 (DGCR6) protein COX14 PF14880.6 EMD60898.1 - 1.6e-17 63.1 1.1 1.6e-17 63.1 1.1 1.9 2 0 0 2 2 2 1 Cytochrome oxidase c assembly Glyco_trans_4_5 PF16994.5 EMD60898.1 - 0.018 14.6 0.1 0.026 14.1 0.1 1.2 1 0 0 1 1 1 0 Glycosyl-transferase family 4 DUF2623 PF11115.8 EMD60899.1 - 0.098 12.7 0.0 0.13 12.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2623) DUF2046 PF09755.9 EMD60902.1 - 0.0092 15.2 1.7 0.02 14.2 1.7 1.5 1 1 0 1 1 1 1 Uncharacterized conserved protein H4 (DUF2046) DivIC PF04977.15 EMD60902.1 - 0.014 15.1 2.5 0.037 13.8 0.7 2.0 2 0 0 2 2 2 0 Septum formation initiator SlyX PF04102.12 EMD60902.1 - 0.021 15.5 0.3 2.9 8.6 0.0 2.4 2 0 0 2 2 2 0 SlyX DUF3972 PF13118.6 EMD60902.1 - 0.095 13.1 0.3 0.93 9.9 0.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3972) KIAA1430 PF13879.6 EMD60902.1 - 0.14 12.9 0.2 0.14 12.9 0.2 1.9 2 1 0 2 2 2 0 KIAA1430 homologue Paf67 PF10255.9 EMD60904.1 - 1.3e-160 534.9 0.1 1.5e-160 534.7 0.1 1.0 1 0 0 1 1 1 1 RNA polymerase I-associated factor PAF67 TPR_2 PF07719.17 EMD60904.1 - 0.079 13.1 0.0 0.4 10.9 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat EthD PF07110.11 EMD60905.1 - 2e-15 57.7 0.0 2.7e-15 57.3 0.0 1.2 1 0 0 1 1 1 1 EthD domain MmlI PF09448.10 EMD60905.1 - 0.00047 20.6 0.1 0.0012 19.3 0.1 1.7 1 1 0 1 1 1 1 Methylmuconolactone methyl-isomerase CN_hydrolase PF00795.22 EMD60906.1 - 1.3e-38 132.8 0.0 1.5e-38 132.6 0.0 1.1 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase TOC159_MAD PF11886.8 EMD60907.1 - 0.05 12.5 0.0 0.074 11.9 0.0 1.2 1 0 0 1 1 1 0 Translocase of chloroplast 159/132, membrane anchor domain DUF5476 PF17570.2 EMD60907.1 - 0.052 13.9 0.0 0.15 12.5 0.0 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5476) BCS1_N PF08740.11 EMD60908.1 - 8.7e-45 153.0 0.0 1.4e-44 152.4 0.0 1.3 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 EMD60908.1 - 1.7e-18 67.3 0.0 4e-18 66.1 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DUF815 PF05673.13 EMD60908.1 - 2.4e-05 23.6 0.0 4.7e-05 22.7 0.0 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF815) AAA_16 PF13191.6 EMD60908.1 - 0.0014 19.1 0.1 0.0086 16.5 0.1 2.4 1 1 0 1 1 1 1 AAA ATPase domain AAA_25 PF13481.6 EMD60908.1 - 0.0019 17.8 0.0 0.0057 16.3 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.6 EMD60908.1 - 0.0025 17.6 0.0 0.23 11.1 0.0 2.9 3 0 0 3 3 3 1 AAA domain AAA_7 PF12775.7 EMD60908.1 - 0.0036 16.9 0.0 0.0074 15.8 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_5 PF07728.14 EMD60908.1 - 0.0079 16.2 0.0 0.019 15.0 0.0 1.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_21 PF13304.6 EMD60908.1 - 0.012 15.5 0.0 0.024 14.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system PPV_E1_C PF00519.17 EMD60908.1 - 0.017 14.0 0.0 0.026 13.4 0.0 1.2 1 0 0 1 1 1 0 Papillomavirus helicase RNA_helicase PF00910.22 EMD60908.1 - 0.021 15.2 0.0 0.28 11.6 0.0 2.3 2 0 0 2 2 2 0 RNA helicase AAA_29 PF13555.6 EMD60908.1 - 0.031 14.0 0.0 0.082 12.7 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain RuvB_N PF05496.12 EMD60908.1 - 0.036 13.8 0.0 0.063 13.0 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain ATPase PF06745.13 EMD60908.1 - 0.048 13.0 0.0 0.093 12.1 0.0 1.4 1 0 0 1 1 1 0 KaiC AAA_18 PF13238.6 EMD60908.1 - 0.069 13.7 0.0 0.17 12.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EMD60908.1 - 0.1 12.8 0.0 0.45 10.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 EMD60908.1 - 0.13 12.6 0.0 0.3 11.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain OPT PF03169.15 EMD60909.1 - 5.8e-197 656.1 30.1 7.4e-197 655.8 30.1 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Lactonase PF10282.9 EMD60911.1 - 5.3e-81 272.5 0.2 7.2e-81 272.1 0.2 1.0 1 0 0 1 1 1 1 Lactonase, 7-bladed beta-propeller He_PIG PF05345.12 EMD60911.1 - 0.0052 16.9 7.5 0.13 12.4 1.7 3.0 2 1 0 2 2 2 2 Putative Ig domain FAD_binding_4 PF01565.23 EMD60912.1 - 4.4e-21 75.1 3.6 8.8e-21 74.1 3.6 1.5 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EMD60912.1 - 8.1e-14 51.5 0.2 2.1e-13 50.1 0.2 1.7 1 0 0 1 1 1 1 Berberine and berberine like Cytokin-bind PF09265.10 EMD60912.1 - 0.082 12.3 0.0 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 Cytokinin dehydrogenase 1, FAD and cytokinin binding Bac_surface_Ag PF01103.23 EMD60913.1 - 1.8e-46 159.1 1.1 2.6e-46 158.6 1.1 1.2 1 0 0 1 1 1 1 Surface antigen UQ_con PF00179.26 EMD60914.1 - 3.2e-21 75.5 0.0 4.6e-21 74.9 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Sugar_tr PF00083.24 EMD60916.1 - 4.8e-108 361.9 15.2 5.7e-108 361.7 15.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD60916.1 - 4.8e-26 91.5 40.1 1.1e-22 80.5 25.2 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF3147 PF11345.8 EMD60916.1 - 0.07 13.5 9.0 3.9 7.9 0.0 3.7 2 1 1 3 3 3 0 Protein of unknown function (DUF3147) Phage_holin_2_3 PF16080.5 EMD60916.1 - 5.8 6.8 6.7 1.3 8.9 0.2 3.0 3 0 0 3 3 3 0 Bacteriophage holin family HP1 BTB PF00651.31 EMD60917.1 - 0.0087 16.3 0.1 0.13 12.5 0.0 2.2 2 0 0 2 2 2 1 BTB/POZ domain Mei5 PF10376.9 EMD60917.1 - 0.013 15.4 1.1 0.02 14.8 1.1 1.2 1 0 0 1 1 1 0 Double-strand recombination repair protein C1_2 PF03107.16 EMD60918.1 - 0.024 14.9 0.8 0.058 13.7 0.8 1.7 1 0 0 1 1 1 0 C1 domain DZR PF12773.7 EMD60918.1 - 0.3 11.2 2.4 0.78 9.8 2.4 1.7 1 0 0 1 1 1 0 Double zinc ribbon DUF676 PF05057.14 EMD60919.1 - 1.5e-41 142.3 0.1 4.7e-28 98.2 0.0 3.3 2 1 1 3 3 3 3 Putative serine esterase (DUF676) PGAP1 PF07819.13 EMD60919.1 - 0.19 11.4 0.0 0.36 10.5 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein Peptidase_M20 PF01546.28 EMD60921.1 - 5.3e-19 68.7 0.0 9.9e-19 67.9 0.0 1.5 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EMD60921.1 - 3.2e-16 59.2 0.0 5.6e-16 58.4 0.0 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 EMD60921.1 - 0.0079 15.9 0.0 0.014 15.1 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 TB2_DP1_HVA22 PF03134.19 EMD60922.1 - 2.7e-21 75.3 4.1 5.2e-21 74.4 4.1 1.5 1 0 0 1 1 1 1 TB2/DP1, HVA22 family Nsp1_C PF05064.13 EMD60922.1 - 0.014 15.2 0.7 0.1 12.4 0.2 2.1 2 0 0 2 2 2 0 Nsp1-like C-terminal region Mgm101p PF06420.12 EMD60923.1 - 3.7e-85 283.7 0.0 5e-85 283.2 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial genome maintenance MGM101 p450 PF00067.22 EMD60924.1 - 4.3e-61 207.1 0.0 5.1e-61 206.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 YL1 PF05764.13 EMD60925.1 - 0.012 15.8 10.1 0.025 14.7 10.1 1.5 1 0 0 1 1 1 0 YL1 nuclear protein ANAPC4_WD40 PF12894.7 EMD60925.1 - 0.023 15.0 0.1 49 4.3 0.0 4.2 3 1 1 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EMD60925.1 - 0.024 13.6 0.0 0.19 10.6 0.0 2.1 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Nop14 PF04147.12 EMD60925.1 - 0.4 8.8 17.3 0.61 8.2 17.3 1.2 1 0 0 1 1 1 0 Nop14-like family Prothymosin PF03247.14 EMD60925.1 - 2.6 8.5 26.9 1.6 9.2 20.5 2.7 2 0 0 2 2 2 0 Prothymosin/parathymosin family DUF1604 PF07713.13 EMD60925.1 - 7.1 6.5 7.4 0.35 10.7 0.8 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1604) Roughex PF06020.11 EMD60925.1 - 7.3 5.6 10.7 12 4.9 10.7 1.2 1 0 0 1 1 1 0 Drosophila roughex protein CDC45 PF02724.14 EMD60925.1 - 7.4 4.7 10.4 15 3.7 10.4 1.4 1 0 0 1 1 1 0 CDC45-like protein TPR_11 PF13414.6 EMD60926.1 - 5.6e-05 22.7 0.2 0.058 13.1 0.4 2.8 2 0 0 2 2 2 2 TPR repeat SUIM_assoc PF16619.5 EMD60926.1 - 0.00019 21.4 1.2 0.00019 21.4 1.2 2.2 2 0 0 2 2 2 1 Unstructured region C-term to UIM in Ataxin3 TPR_17 PF13431.6 EMD60926.1 - 0.016 15.6 0.0 0.11 12.9 0.0 2.5 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_16 PF13432.6 EMD60926.1 - 0.47 11.1 2.5 3.7 8.3 0.1 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat ChAPs PF09295.10 EMD60927.1 - 1.2e-153 511.8 0.0 1.5e-153 511.5 0.0 1.1 1 0 0 1 1 1 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_19 PF14559.6 EMD60927.1 - 1.8e-06 28.3 0.0 0.024 15.2 0.0 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 EMD60927.1 - 6.9e-06 26.4 0.2 2.5 9.2 0.0 4.4 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 EMD60927.1 - 0.00012 22.0 1.5 0.045 13.9 0.2 3.9 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.28 EMD60927.1 - 0.0025 17.6 0.2 0.74 9.7 0.1 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 EMD60927.1 - 0.008 16.3 0.0 0.53 10.6 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 EMD60927.1 - 0.012 16.2 0.1 43 5.0 0.0 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_7 PF13176.6 EMD60927.1 - 0.016 15.2 0.3 6.8 7.0 0.0 3.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_15 PF13429.6 EMD60927.1 - 0.016 14.4 0.8 0.41 9.8 0.3 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_9 PF13371.6 EMD60927.1 - 0.026 14.7 0.0 3.8 7.7 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EMD60927.1 - 0.034 14.4 0.8 12 6.2 0.0 3.3 2 1 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 EMD60927.1 - 0.057 13.7 1.4 31 5.0 0.1 3.9 3 2 0 3 3 3 0 Tetratricopeptide repeat Ribosomal_S9 PF00380.19 EMD60928.1 - 3.7e-33 114.6 0.2 4.1e-33 114.5 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S9/S16 Glyco_hydro_65N PF03636.15 EMD60929.1 - 5.1e-34 117.9 0.0 9e-34 117.1 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, N-terminal domain Glyco_hydro_65m PF03632.15 EMD60929.1 - 3.7e-26 91.9 1.6 4.1e-24 85.2 0.3 2.2 1 1 1 2 2 2 2 Glycosyl hydrolase family 65 central catalytic domain F5_F8_type_C PF00754.25 EMD60929.1 - 3.5e-06 27.2 0.0 1.2e-05 25.4 0.0 1.9 1 0 0 1 1 1 1 F5/8 type C domain HET PF06985.11 EMD60930.1 - 3.5e-33 115.0 1.0 2e-32 112.5 1.0 2.2 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) HET PF06985.11 EMD60931.1 - 1.9e-25 89.9 2.9 2.3e-25 89.7 2.9 1.1 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Amidohydro_1 PF01979.20 EMD60932.1 - 3.3e-73 247.0 0.0 3.8e-73 246.8 0.0 1.0 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EMD60932.1 - 3.3e-07 30.2 1.0 3.3e-05 23.6 0.0 2.2 2 0 0 2 2 2 2 Amidohydrolase family Actin PF00022.19 EMD60933.1 - 1.4e-19 70.0 0.1 1.7e-16 59.8 0.0 2.9 3 1 0 3 3 3 2 Actin cNMP_binding PF00027.29 EMD60934.1 - 1.3e-28 98.9 0.2 2.2e-16 59.7 0.0 5.2 5 0 0 5 5 5 4 Cyclic nucleotide-binding domain Patatin PF01734.22 EMD60934.1 - 2.8e-18 66.8 6.3 3.2e-13 50.3 1.2 3.5 3 0 0 3 3 3 2 Patatin-like phospholipase GDC-P PF02347.16 EMD60935.1 - 5.5e-178 592.2 0.0 6.1e-166 552.5 0.0 2.5 2 1 0 2 2 2 2 Glycine cleavage system P-protein Aminotran_5 PF00266.19 EMD60935.1 - 6.9e-06 25.3 0.0 0.00015 20.8 0.0 2.3 2 0 0 2 2 2 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 EMD60935.1 - 0.0008 18.8 0.0 0.0016 17.8 0.0 1.4 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 EMD60935.1 - 0.09 12.1 0.0 0.18 11.1 0.0 1.4 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Cyto_heme_lyase PF01265.17 EMD60936.1 - 7.9e-118 393.3 0.1 9.3e-118 393.0 0.1 1.0 1 0 0 1 1 1 1 Cytochrome c/c1 heme lyase Yip1 PF04893.17 EMD60937.1 - 2.2e-07 30.8 15.5 1e-06 28.6 15.5 2.0 1 1 0 1 1 1 1 Yip1 domain DnaB PF00772.21 EMD60938.1 - 0.1 12.7 0.0 0.22 11.6 0.0 1.6 1 0 0 1 1 1 0 DnaB-like helicase N terminal domain FlhC PF05280.11 EMD60938.1 - 0.59 9.8 5.8 1 9.1 5.8 1.3 1 0 0 1 1 1 0 Flagellar transcriptional activator (FlhC) Pribosyltran PF00156.27 EMD60939.1 - 4e-08 32.9 0.0 6.2e-08 32.3 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain F-box-like PF12937.7 EMD60940.1 - 0.0004 20.2 0.1 0.00089 19.1 0.1 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EMD60940.1 - 0.00069 19.4 0.0 0.0017 18.1 0.0 1.7 1 0 0 1 1 1 1 F-box domain HSF_DNA-bind PF00447.17 EMD60941.1 - 2.4e-29 101.8 0.8 3.9e-29 101.1 0.8 1.3 1 0 0 1 1 1 1 HSF-type DNA-binding SIP1 PF04938.12 EMD60941.1 - 0.088 12.5 0.1 0.24 11.1 0.0 1.7 2 0 0 2 2 2 0 Survival motor neuron (SMN) interacting protein 1 (SIP1) Pectate_lyase_3 PF12708.7 EMD60942.1 - 2.2e-85 285.9 15.9 2.4e-77 259.6 1.4 2.8 2 1 0 2 2 2 2 Pectate lyase superfamily protein End_N_terminal PF12218.8 EMD60942.1 - 2.7e-07 30.2 0.6 0.0076 15.9 0.1 2.8 2 0 0 2 2 2 2 N terminal extension of bacteriophage endosialidase Beta_helix PF13229.6 EMD60942.1 - 0.00028 20.8 5.8 0.00028 20.8 5.8 2.5 2 0 0 2 2 2 1 Right handed beta helix region 4HBT PF03061.22 EMD60943.1 - 0.00021 21.6 0.0 0.00037 20.8 0.0 1.4 1 0 0 1 1 1 1 Thioesterase superfamily ORC6 PF05460.13 EMD60944.1 - 9.3 5.4 9.4 12 5.0 9.4 1.2 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) RabGAP-TBC PF00566.18 EMD60945.1 - 8.4e-34 117.1 0.0 2.3e-33 115.7 0.0 1.8 1 1 0 1 1 1 1 Rab-GTPase-TBC domain SHIPPO-rpt PF07004.12 EMD60945.1 - 0.67 11.0 4.2 4.5 8.4 0.5 3.1 2 0 0 2 2 2 0 Sperm-tail PG-rich repeat UQ_con PF00179.26 EMD60946.1 - 5.8e-43 145.9 0.1 6.5e-43 145.7 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EMD60946.1 - 5.3e-05 23.5 0.0 7.1e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 RWD domain Prok-E2_B PF14461.6 EMD60946.1 - 0.00063 19.5 0.0 0.00084 19.0 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 EMD60946.1 - 0.036 13.9 0.0 0.046 13.6 0.0 1.2 1 0 0 1 1 1 0 UEV domain BTB PF00651.31 EMD60947.1 - 7.8e-09 35.7 0.1 3.4e-08 33.7 0.0 2.0 3 0 0 3 3 3 1 BTB/POZ domain Skp1_POZ PF03931.15 EMD60947.1 - 0.0012 19.0 0.0 0.002 18.3 0.0 1.3 1 0 0 1 1 1 1 Skp1 family, tetramerisation domain Inositol_P PF00459.25 EMD60948.1 - 1.1e-69 235.0 0.0 1.2e-69 234.9 0.0 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family MFS_1 PF07690.16 EMD60949.1 - 2.1e-09 36.8 29.3 2.1e-09 36.8 29.3 1.9 1 1 0 1 1 1 1 Major Facilitator Superfamily UNC-93 PF05978.16 EMD60949.1 - 9.6e-07 28.6 2.6 9.6e-07 28.6 2.6 2.0 2 0 0 2 2 2 1 Ion channel regulatory protein UNC-93 Sugar_tr PF00083.24 EMD60949.1 - 9.2e-06 24.8 6.4 9.2e-06 24.8 6.4 2.9 3 1 1 4 4 4 1 Sugar (and other) transporter ATPase_gene1 PF09527.10 EMD60949.1 - 3.3 7.9 14.3 4.8 7.4 2.2 3.6 3 0 0 3 3 3 0 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter DAO PF01266.24 EMD60950.1 - 1.1e-43 150.2 0.0 1.3e-43 150.0 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EMD60950.1 - 0.00019 20.8 0.0 0.37 10.0 0.0 2.9 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EMD60950.1 - 0.019 15.0 0.4 3.7 7.5 0.0 2.7 2 0 0 2 2 2 0 FAD-NAD(P)-binding Epimerase PF01370.21 EMD60950.1 - 0.022 14.2 0.0 1.7 8.0 0.0 2.2 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family ThiF PF00899.21 EMD60950.1 - 0.023 14.1 0.0 0.21 10.9 0.0 2.0 2 0 0 2 2 2 0 ThiF family GIDA PF01134.22 EMD60950.1 - 0.062 12.4 0.1 1.1 8.3 0.0 2.3 2 0 0 2 2 2 0 Glucose inhibited division protein A Sacchrp_dh_NADP PF03435.18 EMD60950.1 - 0.087 13.1 0.0 0.23 11.7 0.0 1.7 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain DUF433 PF04255.14 EMD60950.1 - 0.15 11.9 0.1 3.9 7.4 0.0 3.1 4 0 0 4 4 4 0 Protein of unknown function (DUF433) adh_short_C2 PF13561.6 EMD60951.1 - 2.2e-47 161.6 6.4 4.3e-39 134.5 5.0 2.0 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EMD60951.1 - 2.8e-45 154.2 5.0 3.4e-45 153.9 5.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EMD60951.1 - 5.7e-14 52.4 1.9 1e-13 51.6 1.9 1.4 1 1 0 1 1 1 1 KR domain 3HCDH_N PF02737.18 EMD60951.1 - 0.0032 17.4 0.8 0.0063 16.4 0.8 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain AdoHcyase_NAD PF00670.21 EMD60951.1 - 0.015 15.4 0.8 0.024 14.7 0.8 1.4 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.19 EMD60951.1 - 0.015 14.7 0.3 0.024 14.0 0.3 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 EMD60951.1 - 0.02 15.0 0.1 0.041 13.9 0.1 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Sacchrp_dh_NADP PF03435.18 EMD60951.1 - 0.037 14.3 0.2 0.058 13.6 0.2 1.3 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain ADH_zinc_N PF00107.26 EMD60951.1 - 0.34 10.9 4.9 3.4 7.7 3.1 2.9 2 1 0 2 2 2 0 Zinc-binding dehydrogenase TFR_dimer PF04253.15 EMD60952.1 - 9.1e-28 96.8 0.0 1.8e-27 95.8 0.0 1.5 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.17 EMD60952.1 - 1.6e-14 54.0 0.0 2.5e-14 53.4 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 EMD60952.1 - 4.8e-10 39.3 0.0 1.3e-09 38.0 0.0 1.8 1 0 0 1 1 1 1 PA domain Ncstrn_small PF18266.1 EMD60952.1 - 0.08 13.0 0.0 0.33 11.0 0.0 1.9 2 0 0 2 2 2 0 Nicastrin small lobe DUF4078 PF13300.6 EMD60953.1 - 2.8e-24 85.3 14.5 2.8e-24 85.3 14.5 3.3 3 0 0 3 3 3 1 Domain of unknown function (DUF4078) Homoserine_dh PF00742.19 EMD60954.1 - 6.8e-52 175.9 0.0 8.8e-52 175.5 0.0 1.1 1 0 0 1 1 1 1 Homoserine dehydrogenase NAD_binding_3 PF03447.16 EMD60954.1 - 1.4e-15 58.0 0.0 2.8e-15 57.0 0.0 1.5 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain NB-ARC PF00931.22 EMD60954.1 - 0.0051 16.0 0.0 0.0075 15.5 0.0 1.2 1 0 0 1 1 1 1 NB-ARC domain TsaE PF02367.17 EMD60954.1 - 0.056 13.4 0.0 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_25 PF13481.6 EMD60954.1 - 0.09 12.3 0.0 0.22 11.1 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 EMD60954.1 - 0.13 12.6 0.0 0.3 11.3 0.0 1.6 1 1 0 1 1 1 0 AAA domain ATG11 PF10377.9 EMD60957.1 - 1.2e-45 154.7 0.0 1.2e-45 154.7 0.0 3.6 4 0 0 4 4 4 1 Autophagy-related protein 11 Baculo_F PF12259.8 EMD60957.1 - 0.0024 16.5 0.3 0.0024 16.5 0.3 2.5 2 1 0 2 2 2 1 Baculovirus F protein APG17 PF04108.12 EMD60957.1 - 0.0067 15.6 1.7 0.0067 15.6 1.7 6.1 2 2 1 3 3 3 2 Autophagy protein Apg17 CENP-H PF05837.12 EMD60958.1 - 4.8e-30 104.2 4.1 4.8e-30 104.2 4.1 2.1 2 0 0 2 2 2 1 Centromere protein H (CENP-H) FAM196 PF15265.6 EMD60958.1 - 1.8 8.0 7.8 2.7 7.4 7.8 1.3 1 1 0 1 1 1 0 FAM196 family HMG_box PF00505.19 EMD60960.1 - 4.2e-24 84.7 2.4 4.2e-24 84.7 2.4 1.5 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EMD60960.1 - 1.7e-19 70.2 2.5 1.7e-19 70.2 2.5 1.5 2 0 0 2 2 2 1 HMG-box domain CHDNT PF08073.12 EMD60960.1 - 0.0071 16.3 0.2 0.021 14.8 0.0 1.8 2 0 0 2 2 2 1 CHDNT (NUC034) domain Ccdc124 PF06244.12 EMD60960.1 - 0.016 15.7 0.7 0.016 15.7 0.7 2.4 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 124 /Oxs1 Peptidase_S24 PF00717.23 EMD60961.1 - 6.4e-08 32.4 0.0 9.6e-08 31.9 0.0 1.3 1 0 0 1 1 1 1 Peptidase S24-like DUF1682 PF07946.14 EMD60962.1 - 0.52 9.5 6.3 6.1 5.9 7.5 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1682) HAND PF09110.11 EMD60962.1 - 0.75 10.6 8.1 1.5 9.6 8.1 1.5 1 0 0 1 1 1 0 HAND Dicty_REP PF05086.12 EMD60962.1 - 4.8 5.0 5.9 6.5 4.6 5.9 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein LRR_4 PF12799.7 EMD60963.1 - 0.0022 18.3 8.8 7.5 7.1 0.2 5.9 5 1 1 6 6 6 2 Leucine Rich repeats (2 copies) Rad9 PF04139.13 EMD60964.1 - 1e-48 166.0 0.0 1.5e-48 165.5 0.0 1.1 1 0 0 1 1 1 1 Rad9 Phos_pyr_kin PF08543.12 EMD60965.1 - 4.8e-85 284.9 1.7 8.4e-85 284.1 1.7 1.4 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase DEAD PF00270.29 EMD60965.1 - 2.1e-49 167.6 0.0 1.5e-48 164.9 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase TENA_THI-4 PF03070.16 EMD60965.1 - 5.1e-48 163.7 0.2 8.1e-48 163.0 0.2 1.3 1 0 0 1 1 1 1 TENA/THI-4/PQQC family Helicase_C PF00271.31 EMD60965.1 - 8.3e-30 103.4 0.1 1.8e-29 102.3 0.1 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain PfkB PF00294.24 EMD60965.1 - 7e-06 25.6 0.0 1.8e-05 24.2 0.0 1.6 1 1 0 1 1 1 1 pfkB family carbohydrate kinase ResIII PF04851.15 EMD60965.1 - 0.00061 19.8 0.0 0.0017 18.4 0.0 1.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 EMD60965.1 - 0.0018 18.7 0.0 0.23 11.8 0.0 2.4 2 0 0 2 2 2 1 AAA domain UTP25 PF06862.12 EMD60965.1 - 0.043 12.6 0.0 2.5 6.8 0.0 2.1 2 0 0 2 2 2 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 Helicase_C_2 PF13307.6 EMD60965.1 - 0.12 12.6 0.0 0.21 11.8 0.0 1.4 1 0 0 1 1 1 0 Helicase C-terminal domain DUF2207 PF09972.9 EMD60966.1 - 0.093 11.5 0.3 0.09 11.5 0.3 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) EphA2_TM PF14575.6 EMD60966.1 - 0.24 12.3 3.8 0.44 11.5 3.8 1.6 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Virul_fac_BrkB PF03631.15 EMD60966.1 - 0.24 11.0 3.9 4.5 6.8 0.0 2.4 3 0 0 3 3 3 0 Virulence factor BrkB DUF929 PF06053.11 EMD60966.1 - 0.31 10.3 4.8 0.37 10.0 4.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF929) CitMHS PF03600.16 EMD60966.1 - 0.82 8.8 4.5 1.4 8.0 4.5 1.3 1 0 0 1 1 1 0 Citrate transporter AsmA PF05170.14 EMD60966.1 - 2.5 6.8 5.6 2.9 6.6 5.6 1.0 1 0 0 1 1 1 0 AsmA family CD34_antigen PF06365.12 EMD60966.1 - 3.7 7.1 7.2 12 5.4 7.8 1.4 2 0 0 2 2 2 0 CD34/Podocalyxin family Sigma_reg_N PF13800.6 EMD60966.1 - 9 6.7 12.9 5.2 7.4 11.2 1.5 2 0 0 2 2 2 0 Sigma factor regulator N-terminal DUF2633 PF11119.8 EMD60971.1 - 0.04 13.8 1.9 0.094 12.6 1.9 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2633) Tweety PF04906.13 EMD60972.1 - 0.054 12.1 5.0 0.075 11.7 5.0 1.1 1 0 0 1 1 1 0 Tweety PPR_2 PF13041.6 EMD60974.1 - 4.4e-20 71.6 0.0 3.7e-17 62.2 0.0 3.4 3 0 0 3 3 3 1 PPR repeat family PPR PF01535.20 EMD60974.1 - 2.4e-05 24.3 0.3 0.0077 16.4 0.0 4.0 3 0 0 3 3 3 1 PPR repeat PPR_3 PF13812.6 EMD60974.1 - 0.00012 22.1 0.0 0.94 9.6 0.0 3.1 3 0 0 3 3 3 2 Pentatricopeptide repeat domain PPR_1 PF12854.7 EMD60974.1 - 0.00024 20.7 0.7 1.8 8.3 0.0 3.6 3 0 0 3 3 3 2 PPR repeat PPR_long PF17177.4 EMD60974.1 - 0.0044 16.4 0.0 0.034 13.5 0.0 2.3 2 1 0 3 3 3 1 Pentacotripeptide-repeat region of PRORP Rtf2 PF04641.12 EMD60975.1 - 4.3e-52 177.1 14.8 5.3e-51 173.5 14.8 1.9 1 1 0 1 1 1 1 Rtf2 RING-finger zf-Nse PF11789.8 EMD60975.1 - 5.4e-05 22.9 0.0 0.0015 18.3 0.0 2.4 1 1 1 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_5 PF14634.6 EMD60975.1 - 0.068 13.2 0.1 0.12 12.3 0.1 1.4 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_2 PF13639.6 EMD60975.1 - 0.13 12.6 0.0 0.27 11.6 0.0 1.5 1 1 0 1 1 1 0 Ring finger domain zf-RING_11 PF17123.5 EMD60975.1 - 0.15 11.9 0.1 0.54 10.1 0.0 1.9 2 0 0 2 2 2 0 RING-like zinc finger zf-C3HC4_3 PF13920.6 EMD60975.1 - 0.17 11.8 0.4 0.37 10.7 0.4 1.6 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Dicty_REP PF05086.12 EMD60975.1 - 2.8 5.8 13.8 4.3 5.2 13.8 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein IHABP4_N PF16174.5 EMD60975.1 - 5.1 7.7 17.1 6 7.4 14.1 2.1 2 0 0 2 2 2 0 Intracellular hyaluronan-binding protein 4 N-terminal Mucin PF01456.17 EMD60975.1 - 6.4 6.8 18.0 0.45 10.5 13.3 1.5 2 0 0 2 2 2 0 Mucin-like glycoprotein PAP_assoc PF03828.19 EMD60976.1 - 2.1e-20 72.7 0.0 4.8e-20 71.5 0.0 1.7 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 EMD60976.1 - 0.00029 21.1 0.0 0.0012 19.1 0.0 2.0 2 0 0 2 2 2 1 Nucleotidyltransferase domain Polbeta PF18765.1 EMD60976.1 - 0.034 14.2 0.0 0.072 13.2 0.0 1.5 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase PAP_central PF04928.17 EMD60976.1 - 0.093 11.7 0.4 0.56 9.1 0.1 2.3 3 0 0 3 3 3 0 Poly(A) polymerase central domain DUF5320 PF17253.2 EMD60976.1 - 2.3 9.4 9.5 3.8 8.6 7.9 2.3 1 1 1 2 2 2 0 Family of unknown function (DUF5320) DUF383 PF04063.14 EMD60978.1 - 1.2e-65 220.8 1.0 6.2e-65 218.4 0.0 2.4 4 0 0 4 4 4 1 Domain of unknown function (DUF383) DUF384 PF04064.13 EMD60978.1 - 3.5e-21 74.8 4.4 1.1e-20 73.2 4.4 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF384) Cnd1 PF12717.7 EMD60978.1 - 0.026 14.6 1.7 0.071 13.2 1.7 1.7 1 0 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 EMD60978.1 - 0.1 12.9 0.0 34 5.1 0.0 3.5 3 0 0 3 3 3 0 HEAT repeat HEAT_2 PF13646.6 EMD60978.1 - 0.22 12.0 2.6 8.2 6.9 0.0 3.2 2 1 1 3 3 3 0 HEAT repeats Abhydrolase_1 PF00561.20 EMD60980.1 - 1.4e-10 41.3 0.1 1.6e-09 37.8 0.1 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EMD60980.1 - 7.8e-10 39.7 0.2 9.5e-10 39.4 0.2 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EMD60980.1 - 0.038 13.3 0.0 0.36 10.0 0.0 2.0 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Abhydrolase_2 PF02230.16 EMD60980.1 - 0.051 13.4 0.0 10 5.9 0.0 2.3 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase DUF1057 PF06342.12 EMD60980.1 - 0.094 11.7 0.0 0.13 11.3 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1057) ETF_QO PF05187.13 EMD60986.1 - 9.9e-49 163.8 0.7 1.6e-48 163.1 0.7 1.4 1 0 0 1 1 1 1 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S FAD_binding_2 PF00890.24 EMD60986.1 - 9.8e-07 28.2 0.7 0.00046 19.4 0.7 2.2 2 0 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 EMD60986.1 - 4.9e-06 26.7 0.1 1.5e-05 25.1 0.0 1.9 2 0 0 2 2 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EMD60986.1 - 4.9e-06 26.4 1.4 0.00077 19.1 0.8 2.4 1 1 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EMD60986.1 - 3.7e-05 23.1 0.0 0.00012 21.5 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EMD60986.1 - 9.3e-05 21.8 0.0 0.00013 21.3 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 EMD60986.1 - 0.00026 20.3 0.1 0.0013 18.0 0.2 1.9 2 0 0 2 2 2 1 Thi4 family HI0933_like PF03486.14 EMD60986.1 - 0.00035 19.4 0.4 0.00052 18.8 0.4 1.2 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox PF00070.27 EMD60986.1 - 0.00073 20.1 0.3 1.8 9.2 0.3 2.7 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EMD60986.1 - 0.0012 18.1 0.3 0.0017 17.6 0.3 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EMD60986.1 - 0.0025 17.2 0.0 0.0034 16.8 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EMD60986.1 - 0.0088 16.0 0.0 0.017 15.1 0.0 1.6 1 0 0 1 1 1 1 FAD-NAD(P)-binding Lycopene_cycl PF05834.12 EMD60986.1 - 0.038 13.0 0.0 0.052 12.6 0.0 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein Fer4_7 PF12838.7 EMD60986.1 - 0.049 14.2 0.9 0.11 13.2 0.9 1.5 1 0 0 1 1 1 0 4Fe-4S dicluster domain Trp_halogenase PF04820.14 EMD60986.1 - 0.057 12.3 0.1 0.22 10.3 0.2 1.8 2 0 0 2 2 2 0 Tryptophan halogenase AlaDh_PNT_C PF01262.21 EMD60986.1 - 0.058 12.7 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.22 EMD60986.1 - 0.15 11.1 0.5 0.22 10.6 0.5 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A RRM_1 PF00076.22 EMD60987.1 - 2.2e-22 78.6 0.0 2.3e-10 40.1 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_Rrp7 PF17799.1 EMD60987.1 - 0.29 10.9 0.0 20 4.9 0.0 2.1 2 0 0 2 2 2 0 Rrp7 RRM-like N-terminal domain zinc_ribbon_15 PF17032.5 EMD60988.1 - 0.061 14.1 1.5 0.061 14.1 1.5 1.7 2 0 0 2 2 2 0 zinc-ribbon family Ribosomal_L31 PF01197.18 EMD60988.1 - 0.32 11.3 1.4 1.1 9.5 0.0 2.3 3 0 0 3 3 3 0 Ribosomal protein L31 MHB PF16525.5 EMD60991.1 - 0.025 14.8 0.4 0.045 14.0 0.4 1.4 1 0 0 1 1 1 0 Haemophore, haem-binding Ccdc124 PF06244.12 EMD60991.1 - 0.031 14.8 6.1 0.047 14.2 6.1 1.5 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 124 /Oxs1 Dioxygenase_C PF00775.21 EMD60992.1 - 8.1e-41 139.4 0.0 1.2e-40 138.9 0.0 1.2 1 0 0 1 1 1 1 Dioxygenase Dioxygenase_N PF04444.14 EMD60992.1 - 1.4e-31 108.1 0.0 3.1e-31 107.0 0.0 1.6 1 0 0 1 1 1 1 Catechol dioxygenase N terminus CarboxypepD_reg PF13620.6 EMD60992.1 - 0.0031 17.8 0.1 0.012 15.9 0.1 2.0 1 1 0 1 1 1 1 Carboxypeptidase regulatory-like domain Cyt-b5 PF00173.28 EMD60994.1 - 1e-12 48.0 0.0 1.3e-12 47.7 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain DUF3445 PF11927.8 EMD60995.1 - 2.8e-73 246.3 0.0 3.4e-73 246.0 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3445) Pkinase PF00069.25 EMD60996.1 - 1.1e-47 162.6 0.0 3.4e-47 161.0 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD60996.1 - 6.4e-28 97.7 0.0 1e-27 97.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMD60996.1 - 0.00075 18.9 0.0 0.0014 18.0 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EMD60996.1 - 0.003 17.5 0.1 0.0094 15.9 0.1 1.9 2 0 0 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.22 EMD60996.1 - 0.083 12.5 0.3 0.41 10.2 0.3 2.1 1 1 0 1 1 1 0 RIO1 family Pox_ser-thr_kin PF05445.11 EMD60996.1 - 0.12 11.4 0.0 0.19 10.6 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase DUF3246 PF11596.8 EMD60996.1 - 2.5 7.5 7.3 2.3 7.6 0.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3246) Zn_ribbon_recom PF13408.6 EMD60997.1 - 0.17 12.4 2.1 0.31 11.6 2.1 1.6 1 1 0 1 1 1 0 Recombinase zinc beta ribbon domain Zn_clus PF00172.18 EMD60999.1 - 3.3e-09 36.7 10.9 3.3e-09 36.7 10.9 1.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF3425 PF11905.8 EMD60999.1 - 1.2e-08 35.0 1.0 1.9e-08 34.3 1.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) EVI2A PF05399.11 EMD61001.1 - 0.81 9.2 5.6 0.94 9.0 5.6 1.0 1 0 0 1 1 1 0 Ectropic viral integration site 2A protein (EVI2A) p450 PF00067.22 EMD61003.1 - 7e-72 242.6 0.0 8.8e-72 242.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Fasciclin PF02469.22 EMD61004.1 - 1.1e-51 174.4 4.1 4.6e-28 98.0 0.4 2.1 2 0 0 2 2 2 2 Fasciclin domain DUF211 PF02680.14 EMD61004.1 - 1.7 8.9 7.1 9.6 6.4 1.9 2.6 2 0 0 2 2 2 0 Uncharacterized ArCR, COG1888 BBIP10 PF14777.6 EMD61005.1 - 0.054 13.1 1.0 0.12 12.0 1.0 1.5 1 0 0 1 1 1 0 Cilia BBSome complex subunit 10 RNA_pol_Rpb6 PF01192.22 EMD61005.1 - 0.055 13.4 0.0 0.16 11.9 0.0 1.8 1 0 0 1 1 1 0 RNA polymerase Rpb6 PAT1 PF09770.9 EMD61005.1 - 2.3 6.4 10.9 2.7 6.2 10.9 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 UPF0239 PF06783.11 EMD61005.1 - 6.8 6.9 0.0 6.8 6.9 0.0 3.4 3 1 1 4 4 4 0 Uncharacterised protein family (UPF0239) Apt1 PF10351.9 EMD61005.1 - 7.4 5.3 12.9 8.7 5.1 12.9 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain DHquinase_I PF01487.15 EMD61007.1 - 3.4e-22 79.8 0.0 7.7e-22 78.7 0.0 1.5 1 0 0 1 1 1 1 Type I 3-dehydroquinase Shikimate_dh_N PF08501.11 EMD61007.1 - 3.7e-19 68.7 0.0 9e-19 67.5 0.0 1.7 1 0 0 1 1 1 1 Shikimate dehydrogenase substrate binding domain SKI PF01202.22 EMD61007.1 - 8.7e-11 42.2 0.0 1.8e-10 41.2 0.0 1.5 1 0 0 1 1 1 1 Shikimate kinase Shikimate_DH PF01488.20 EMD61007.1 - 9.6e-10 38.7 0.4 1.7e-08 34.6 0.1 2.3 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase SDH_C PF18317.1 EMD61007.1 - 7.5e-09 35.2 0.2 1.8e-08 34.0 0.2 1.7 1 0 0 1 1 1 1 Shikimate 5'-dehydrogenase C-terminal domain F420_oxidored PF03807.17 EMD61007.1 - 0.00024 21.6 0.0 0.00096 19.7 0.0 1.9 2 0 0 2 2 1 1 NADP oxidoreductase coenzyme F420-dependent Sacchrp_dh_NADP PF03435.18 EMD61007.1 - 0.0014 18.9 0.0 0.0038 17.5 0.0 1.8 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain AAA_18 PF13238.6 EMD61007.1 - 0.0063 17.1 0.0 0.016 15.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 EMD61007.1 - 0.067 12.9 0.0 0.17 11.6 0.0 1.6 1 1 0 1 1 1 0 IstB-like ATP binding protein AAA_16 PF13191.6 EMD61007.1 - 0.08 13.3 0.1 0.23 11.8 0.0 1.8 2 0 0 2 2 2 0 AAA ATPase domain PglD_N PF17836.1 EMD61007.1 - 0.16 12.6 0.0 0.78 10.4 0.0 2.2 3 0 0 3 3 2 0 PglD N-terminal domain AAA PF00004.29 EMD61007.1 - 0.17 12.3 0.0 0.38 11.2 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Fungal_trans PF04082.18 EMD61008.1 - 6.2e-12 45.1 0.1 2.5e-11 43.1 0.1 2.0 1 1 0 1 1 1 1 Fungal specific transcription factor domain Virul_fac_BrkB PF03631.15 EMD61009.1 - 0.021 14.4 3.5 0.033 13.8 3.5 1.2 1 0 0 1 1 1 0 Virulence factor BrkB MerR_2 PF13591.6 EMD61009.1 - 0.21 11.5 0.0 0.67 9.8 0.1 1.7 2 0 0 2 2 2 0 MerR HTH family regulatory protein DUF3112 PF11309.8 EMD61010.1 - 8.8e-09 35.1 9.4 2.1e-07 30.6 9.4 2.5 1 1 0 1 1 1 1 Protein of unknown function (DUF3112) YqgF PF14639.6 EMD61010.1 - 0.044 13.6 0.0 0.081 12.7 0.0 1.3 1 0 0 1 1 1 0 Holliday-junction resolvase-like of SPT6 Vps35 PF03635.17 EMD61011.1 - 0 1034.3 5.6 0 1034.1 5.6 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 Pro_3_hydrox_C PF05373.11 EMD61011.1 - 0.064 13.3 0.5 11 6.2 0.0 2.9 3 0 0 3 3 3 0 L-proline 3-hydroxylase, C-terminal Dicty_REP PF05086.12 EMD61011.1 - 0.075 11.0 1.9 0.11 10.4 1.9 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein RuvA_N PF01330.21 EMD61012.1 - 0.13 12.4 0.2 0.51 10.5 0.3 1.8 2 0 0 2 2 2 0 RuvA N terminal domain HET PF06985.11 EMD61013.1 - 5.8e-18 65.7 0.0 6.3e-18 65.5 0.0 1.0 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) FtsK_SpoIIIE PF01580.18 EMD61013.1 - 0.00063 19.2 0.0 0.00066 19.1 0.0 1.1 1 0 0 1 1 1 1 FtsK/SpoIIIE family KR PF08659.10 EMD61015.1 - 1.5e-62 210.7 0.1 1.5e-62 210.7 0.1 1.7 2 0 0 2 2 1 1 KR domain ketoacyl-synt PF00109.26 EMD61015.1 - 1.1e-48 166.0 1.8 3.6e-48 164.4 0.1 2.7 3 1 0 3 3 3 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 EMD61015.1 - 2.7e-41 142.1 0.0 4.9e-41 141.3 0.0 1.4 1 0 0 1 1 1 1 Acyl transferase domain PS-DH PF14765.6 EMD61015.1 - 1.3e-40 139.6 0.0 2.2e-40 138.8 0.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase Ketoacyl-synt_C PF02801.22 EMD61015.1 - 5.7e-37 126.3 0.0 1.4e-36 125.1 0.0 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain ADH_zinc_N PF00107.26 EMD61015.1 - 2.4e-17 63.1 0.2 8.2e-17 61.4 0.1 2.0 2 0 0 2 2 1 1 Zinc-binding dehydrogenase Methyltransf_12 PF08242.12 EMD61015.1 - 8.5e-16 58.5 0.0 2.2e-15 57.2 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain KAsynt_C_assoc PF16197.5 EMD61015.1 - 3.6e-14 53.2 0.4 1.7e-09 38.1 0.0 3.1 3 0 0 3 3 3 2 Ketoacyl-synthetase C-terminal extension adh_short PF00106.25 EMD61015.1 - 1.9e-10 40.5 0.8 2e-09 37.2 0.1 2.8 3 0 0 3 3 3 1 short chain dehydrogenase ADH_zinc_N_2 PF13602.6 EMD61015.1 - 2.8e-09 38.1 0.0 1.6e-08 35.7 0.0 2.4 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Methyltransf_11 PF08241.12 EMD61015.1 - 3.7e-09 37.1 0.0 1.3e-08 35.4 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMD61015.1 - 2.9e-08 34.3 0.0 1.2e-07 32.3 0.0 2.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EMD61015.1 - 5.6e-08 32.8 0.0 1.3e-07 31.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain ADH_N PF08240.12 EMD61015.1 - 1.1e-05 25.2 0.0 2.5e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Methyltransf_31 PF13847.6 EMD61015.1 - 1.8e-05 24.6 0.0 5.9e-05 22.9 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain PP-binding PF00550.25 EMD61015.1 - 2.4e-05 24.6 0.0 5.8e-05 23.4 0.0 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site Thiolase_N PF00108.23 EMD61015.1 - 4.8e-05 22.9 0.1 9.5e-05 21.9 0.1 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain Ubie_methyltran PF01209.18 EMD61015.1 - 0.0027 17.1 0.0 0.0054 16.1 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family ACP_syn_III PF08545.10 EMD61015.1 - 0.013 15.4 0.1 0.045 13.6 0.1 1.9 2 0 0 2 2 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III SAT PF16073.5 EMD61015.1 - 0.019 14.7 2.1 0.095 12.4 0.1 2.8 2 1 0 2 2 2 0 Starter unit:ACP transacylase in aflatoxin biosynthesis p450 PF00067.22 EMD61016.1 - 7.1e-50 170.1 0.0 8.6e-50 169.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 EMD61017.1 - 9e-77 258.8 0.0 1.2e-76 258.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 adh_short PF00106.25 EMD61018.1 - 9.4e-20 70.9 0.0 1.4e-16 60.5 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EMD61018.1 - 8.2e-10 38.6 0.0 2.3e-07 30.6 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD61018.1 - 8.4e-05 22.6 0.0 0.00012 22.0 0.0 1.2 1 0 0 1 1 1 1 KR domain Av_adeno_fibre PF06536.11 EMD61018.1 - 0.046 13.6 0.4 10 6.1 0.1 2.4 2 0 0 2 2 2 0 Avian adenovirus fibre, N-terminal Polysacc_synt_2 PF02719.15 EMD61018.1 - 0.08 12.1 0.0 0.12 11.4 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein adh_short PF00106.25 EMD61019.1 - 8.5e-36 123.3 0.0 1.1e-35 122.8 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD61019.1 - 5.5e-27 94.8 0.0 8.4e-27 94.2 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD61019.1 - 1.2e-07 31.8 0.5 5.3e-07 29.7 0.5 1.8 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 EMD61019.1 - 0.0018 17.8 0.0 0.0024 17.4 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF1776 PF08643.10 EMD61019.1 - 0.017 14.5 0.1 0.025 14.0 0.1 1.3 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) 2-Hacid_dh_C PF02826.19 EMD61019.1 - 0.03 13.7 0.0 0.047 13.0 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Methyltransf_2 PF00891.18 EMD61020.1 - 2.5e-22 79.2 0.0 3.4e-22 78.8 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase domain Dimerisation2 PF16864.5 EMD61020.1 - 0.025 14.6 0.0 0.069 13.1 0.0 1.7 2 0 0 2 2 2 0 Dimerisation domain HpcH_HpaI PF03328.14 EMD61021.1 - 2.1e-24 85.9 0.0 2.9e-24 85.4 0.0 1.1 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family G10 PF01125.17 EMD61021.1 - 0.013 15.3 0.0 0.023 14.5 0.0 1.3 1 0 0 1 1 1 0 G10 protein Gemini_AC4_5 PF04807.12 EMD61021.1 - 0.099 12.3 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 Geminivirus AC4/5 conserved region TMEM154 PF15102.6 EMD61022.1 - 0.00024 21.0 0.1 0.00031 20.7 0.1 1.1 1 0 0 1 1 1 1 TMEM154 protein family Fe-S_biosyn PF01521.20 EMD61024.1 - 3.8e-12 46.4 0.0 5.1e-12 46.0 0.0 1.2 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis Aminotran_5 PF00266.19 EMD61025.1 - 1.5e-11 43.9 0.0 7.7e-09 35.0 0.0 2.1 2 0 0 2 2 2 2 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 EMD61025.1 - 0.0066 15.0 0.0 0.0096 14.5 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DNA_pol_B PF00136.21 EMD61026.1 - 5.4e-113 378.1 0.5 1e-112 377.2 0.5 1.5 1 0 0 1 1 1 1 DNA polymerase family B zf-DNA_Pol PF08996.10 EMD61026.1 - 7e-62 208.5 0.0 1.8e-61 207.1 0.0 1.8 1 0 0 1 1 1 1 DNA Polymerase alpha zinc finger DNA_pol_B_exo1 PF03104.19 EMD61026.1 - 2.1e-41 142.2 0.0 4.5e-41 141.1 0.0 1.6 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_alpha_N PF12254.8 EMD61026.1 - 3e-24 84.9 7.8 8.7e-24 83.4 7.8 1.9 1 0 0 1 1 1 1 DNA polymerase alpha subunit p180 N terminal DNA_pol_B_2 PF03175.13 EMD61026.1 - 0.025 13.4 0.8 0.064 12.1 0.0 1.9 2 1 0 2 2 2 0 DNA polymerase type B, organellar and viral RNase_T PF00929.24 EMD61027.1 - 2e-20 74.0 0.4 2.3e-20 73.8 0.4 1.0 1 0 0 1 1 1 1 Exonuclease Lipase_GDSL_2 PF13472.6 EMD61028.1 - 6.7e-11 42.9 0.2 8.3e-11 42.6 0.2 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EMD61028.1 - 1.7e-06 28.2 0.1 2.7e-06 27.5 0.1 1.3 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Inhibitor_I78 PF11720.8 EMD61028.1 - 0.055 13.5 0.0 0.2 11.8 0.0 1.9 1 1 1 2 2 2 0 Peptidase inhibitor I78 family MBG PF17883.1 EMD61028.1 - 0.15 12.7 1.2 0.43 11.2 0.3 2.2 2 0 0 2 2 2 0 MBG domain bZIP_1 PF00170.21 EMD61029.1 - 1.9e-10 40.7 9.2 7.8e-10 38.7 9.2 1.9 1 1 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EMD61029.1 - 0.022 14.9 10.6 0.11 12.6 6.7 2.4 1 1 1 2 2 2 0 Basic region leucine zipper ATAD4 PF15321.6 EMD61029.1 - 0.086 14.2 0.5 0.086 14.2 0.5 2.1 2 0 0 2 2 2 0 ATPase family AAA domain containing 4 Pterin_4a PF01329.19 EMD61030.1 - 2e-25 88.8 0.1 2.7e-25 88.3 0.1 1.2 1 0 0 1 1 1 1 Pterin 4 alpha carbinolamine dehydratase Actin PF00022.19 EMD61031.1 - 1.8e-24 86.1 0.0 2.3e-12 46.2 0.0 3.0 2 1 0 2 2 2 2 Actin MreB_Mbl PF06723.13 EMD61031.1 - 0.0024 16.8 0.0 0.051 12.4 0.0 2.1 2 0 0 2 2 2 1 MreB/Mbl protein Actin_micro PF17003.5 EMD61031.1 - 0.0063 15.7 0.0 0.03 13.5 0.1 1.9 2 0 0 2 2 2 1 Putative actin-like family DUF1765 PF08578.10 EMD61033.1 - 7.5e-41 139.5 4.5 1.3e-40 138.7 4.5 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1765) ATP_sub_h PF10775.9 EMD61034.1 - 3.4e-28 97.4 0.9 4.6e-28 97.0 0.9 1.2 1 0 0 1 1 1 1 ATP synthase complex subunit h TFIIB PF00382.19 EMD61035.1 - 1.7e-32 111.2 0.5 1.9e-16 59.9 0.2 2.5 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 EMD61035.1 - 1.6e-13 49.9 0.9 2.9e-13 49.1 0.9 1.5 1 0 0 1 1 1 1 TFIIB zinc-binding RB_B PF01857.20 EMD61035.1 - 4.4e-05 23.5 0.0 8.2e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 Retinoblastoma-associated protein B domain Sld7_C PF18596.1 EMD61035.1 - 0.081 13.1 0.6 0.64 10.2 0.3 2.3 2 1 0 2 2 2 0 Sld7 C-terminal domain PPR_long PF17177.4 EMD61035.1 - 0.094 12.1 0.2 0.19 11.1 0.2 1.4 1 0 0 1 1 1 0 Pentacotripeptide-repeat region of PRORP zf-ribbon_3 PF13248.6 EMD61035.1 - 0.12 11.8 2.3 1.1 8.8 0.1 2.4 2 0 0 2 2 2 0 zinc-ribbon domain CUE PF02845.16 EMD61037.1 - 1.1e-09 37.9 0.0 1.7e-09 37.2 0.0 1.4 1 0 0 1 1 1 1 CUE domain Metal_resist PF13801.6 EMD61037.1 - 0.0053 17.0 0.2 0.0053 17.0 0.2 3.3 3 0 0 3 3 3 1 Heavy-metal resistance DUF3697 PF12478.8 EMD61037.1 - 0.0067 16.5 0.3 0.019 15.0 0.3 1.8 1 0 0 1 1 1 1 Ubiquitin-associated protein 2 Lipoprotein_18 PF06804.11 EMD61038.1 - 0.15 11.1 0.0 0.21 10.6 0.0 1.2 1 0 0 1 1 1 0 NlpB/DapX lipoprotein Aldo_ket_red PF00248.21 EMD61039.1 - 4.7e-50 170.4 0.0 1.2e-49 169.1 0.0 1.6 1 1 0 1 1 1 1 Aldo/keto reductase family ScsC_N PF18312.1 EMD61039.1 - 0.026 14.3 0.4 0.074 12.9 0.0 1.9 2 0 0 2 2 2 0 Copper resistance protein ScsC N-terminal domain Hydrolase_6 PF13344.6 EMD61040.1 - 2.8e-22 78.7 0.0 5.7e-22 77.7 0.0 1.6 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EMD61040.1 - 1.7e-19 69.6 0.0 5.7e-19 68.0 0.0 1.9 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 EMD61040.1 - 0.026 14.8 0.0 2.1 8.6 0.0 3.1 2 1 1 3 3 3 0 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EMD61040.1 - 0.062 13.4 0.0 0.73 9.9 0.0 2.3 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Ribosomal_S28e PF01200.18 EMD61042.1 - 8.9e-31 105.7 1.4 9.9e-31 105.5 1.4 1.0 1 0 0 1 1 1 1 Ribosomal protein S28e Pectate_lyase PF03211.13 EMD61043.1 - 2.2e-66 223.3 1.6 2.8e-66 223.0 1.6 1.1 1 0 0 1 1 1 1 Pectate lyase Epimerase PF01370.21 EMD61044.1 - 1e-13 51.4 0.0 1.8e-13 50.5 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 EMD61044.1 - 1.7e-10 40.5 0.0 1.7e-07 30.6 0.0 2.1 2 0 0 2 2 2 2 Male sterility protein 3Beta_HSD PF01073.19 EMD61044.1 - 9.3e-09 34.7 0.0 1.3e-08 34.2 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 EMD61044.1 - 4.5e-08 32.9 0.0 7.5e-08 32.1 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 EMD61044.1 - 2.8e-06 27.4 0.0 4.6e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Polysacc_synt_2 PF02719.15 EMD61044.1 - 0.0024 17.1 0.0 0.0033 16.6 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NmrA PF05368.13 EMD61044.1 - 0.0028 17.3 0.1 0.0064 16.1 0.1 1.7 1 1 0 1 1 1 1 NmrA-like family adh_short PF00106.25 EMD61044.1 - 0.039 13.4 0.0 0.06 12.8 0.0 1.4 1 0 0 1 1 1 0 short chain dehydrogenase DAO PF01266.24 EMD61045.1 - 1e-43 150.3 0.0 1.2e-43 150.1 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EMD61045.1 - 5.8e-05 23.2 0.0 0.00012 22.2 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 EMD61045.1 - 0.00025 21.1 0.0 0.0063 16.5 0.0 2.4 2 0 0 2 2 2 1 FAD-NAD(P)-binding GIDA PF01134.22 EMD61045.1 - 0.00066 18.9 0.0 0.001 18.3 0.0 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A Pyr_redox_2 PF07992.14 EMD61045.1 - 0.001 18.4 0.0 0.015 14.5 0.0 2.2 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Glu_dehyd_C PF16912.5 EMD61045.1 - 0.0085 15.6 0.0 0.015 14.8 0.0 1.4 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus Thi4 PF01946.17 EMD61045.1 - 0.023 13.9 0.0 0.047 12.9 0.0 1.4 1 0 0 1 1 1 0 Thi4 family GMC_oxred_N PF00732.19 EMD61045.1 - 0.051 12.9 0.0 0.93 8.8 0.0 2.1 2 0 0 2 2 2 0 GMC oxidoreductase Sacchrp_dh_NADP PF03435.18 EMD61045.1 - 0.15 12.3 0.0 0.3 11.3 0.0 1.5 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain K_oxygenase PF13434.6 EMD61045.1 - 0.19 10.9 0.0 0.29 10.2 0.0 1.2 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) Methyltransf_23 PF13489.6 EMD61046.1 - 9.7e-30 103.6 0.0 1.5e-29 103.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMD61046.1 - 4.9e-07 30.4 0.0 1.4e-06 28.9 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMD61046.1 - 5.5e-06 26.3 0.0 9.1e-06 25.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMD61046.1 - 1.3e-05 25.8 0.0 2.7e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMD61046.1 - 2.5e-05 24.8 0.0 5.5e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain DUF812 PF05667.11 EMD61048.1 - 0.25 10.2 4.1 0.33 9.8 4.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF812) Pannexin_like PF12534.8 EMD61048.1 - 2.2 7.3 5.2 4.1 6.4 5.2 1.3 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 DUF2235 PF09994.9 EMD61050.1 - 1.5e-81 274.0 0.0 2.1e-81 273.4 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) Hydrolase_4 PF12146.8 EMD61050.1 - 0.016 14.5 0.1 0.027 13.8 0.1 1.2 1 0 0 1 1 1 0 Serine aminopeptidase, S33 p450 PF00067.22 EMD61051.1 - 4.5e-23 81.7 0.1 6.9e-23 81.1 0.1 1.2 1 1 0 1 1 1 1 Cytochrome P450 BUD22 PF09073.10 EMD61053.1 - 0.0016 17.9 8.9 0.0027 17.1 8.9 1.4 1 0 0 1 1 1 1 BUD22 SAPS PF04499.15 EMD61053.1 - 0.032 13.0 3.8 0.042 12.6 3.8 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Zip PF02535.22 EMD61053.1 - 0.04 13.1 1.0 0.053 12.7 1.0 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter CDC45 PF02724.14 EMD61053.1 - 0.058 11.7 1.0 0.062 11.6 1.0 1.2 1 0 0 1 1 1 0 CDC45-like protein Apt1 PF10351.9 EMD61053.1 - 0.26 10.1 5.8 0.31 9.8 5.8 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Presenilin PF01080.17 EMD61053.1 - 0.33 9.7 5.2 0.47 9.2 5.2 1.3 1 0 0 1 1 1 0 Presenilin Neur_chan_memb PF02932.16 EMD61053.1 - 0.39 10.7 2.5 0.63 10.1 2.5 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region SLC12 PF03522.15 EMD61053.1 - 1 8.3 4.7 1.4 7.8 4.7 1.1 1 0 0 1 1 1 0 Solute carrier family 12 SOG2 PF10428.9 EMD61053.1 - 1.1 8.4 9.6 1.2 8.3 9.6 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein Macoilin PF09726.9 EMD61053.1 - 2.5 6.5 7.8 2.7 6.4 7.8 1.1 1 0 0 1 1 1 0 Macoilin family Nop14 PF04147.12 EMD61053.1 - 5 5.2 12.4 6.8 4.8 12.4 1.0 1 0 0 1 1 1 0 Nop14-like family NOA36 PF06524.12 EMD61053.1 - 6.4 6.0 18.4 10 5.3 18.4 1.2 1 0 0 1 1 1 0 NOA36 protein FAM220 PF15487.6 EMD61053.1 - 8.1 6.0 7.9 12 5.4 7.9 1.2 1 0 0 1 1 1 0 FAM220 family SNF2_N PF00176.23 EMD61054.1 - 3e-65 220.3 0.0 5.8e-65 219.3 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EMD61054.1 - 1.5e-18 67.2 0.0 4.1e-18 65.7 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EMD61054.1 - 3.6e-07 30.3 0.0 1e-06 28.9 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit TFIIF_beta PF02270.15 EMD61054.1 - 0.042 14.0 0.1 0.1 12.7 0.1 1.6 1 0 0 1 1 1 0 TFIIF, beta subunit HTH domain BRE1 PF08647.11 EMD61054.1 - 0.059 13.4 5.2 0.19 11.8 5.2 1.9 1 0 0 1 1 1 0 BRE1 E3 ubiquitin ligase DUF2730 PF10805.8 EMD61054.1 - 0.079 13.1 1.1 0.18 11.9 1.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2730) FapA PF03961.13 EMD61054.1 - 0.46 9.0 2.9 0.78 8.3 2.9 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A TMF_DNA_bd PF12329.8 EMD61054.1 - 1.4 9.0 7.5 25 5.0 0.1 2.8 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding DNA_pol3_tau_4 PF12168.8 EMD61054.1 - 1.6 9.3 12.1 0.14 12.7 5.6 2.7 2 0 0 2 2 2 0 DNA polymerase III subunits tau domain IV DnaB-binding Prefoldin_2 PF01920.20 EMD61054.1 - 2.1 8.3 8.6 0.98 9.4 0.1 3.1 2 1 1 3 3 3 0 Prefoldin subunit Asp-B-Hydro_N PF05279.11 EMD61055.1 - 0.017 15.2 1.3 0.027 14.5 1.3 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region FA_hydroxylase PF04116.13 EMD61056.1 - 6.5e-27 94.5 17.8 6.5e-27 94.5 17.8 1.8 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily Paf1 PF03985.13 EMD61057.1 - 2.1e-62 211.5 0.0 4.4e-62 210.5 0.0 1.5 1 1 0 1 1 1 1 Paf1 DUF5531 PF17671.1 EMD61059.1 - 0.18 11.7 0.9 0.26 11.2 0.9 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5531) HlyIII PF03006.20 EMD61060.1 - 1e-55 188.9 17.8 1.3e-55 188.6 17.8 1.1 1 0 0 1 1 1 1 Haemolysin-III related UPF0122 PF04297.14 EMD61061.1 - 0.038 14.2 0.5 5.9 7.2 0.0 2.5 2 0 0 2 2 2 0 Putative helix-turn-helix protein, YlxM / p13 like RNA_pol_3_Rpc31 PF11705.8 EMD61062.1 - 6.1e-53 180.4 7.3 7.6e-53 180.1 7.3 1.1 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 BUD22 PF09073.10 EMD61062.1 - 0.15 11.4 11.8 0.16 11.3 11.8 1.1 1 0 0 1 1 1 0 BUD22 Pox_Ag35 PF03286.14 EMD61062.1 - 0.49 10.2 8.0 0.74 9.6 8.0 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Shadoo PF14999.6 EMD61062.1 - 1 9.5 7.6 2.7 8.1 7.6 1.7 1 0 0 1 1 1 0 Shadow of prion protein, neuroprotective FCH PF00611.23 EMD61063.1 - 2.9e-12 46.7 0.0 6.7e-12 45.5 0.0 1.7 1 0 0 1 1 1 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_1 PF00018.28 EMD61063.1 - 5.2e-12 45.2 0.0 9.8e-12 44.3 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EMD61063.1 - 3.1e-11 42.9 0.0 5.9e-11 42.1 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EMD61063.1 - 3.7e-11 42.5 0.0 1.5e-10 40.6 0.0 2.1 1 0 0 1 1 1 1 Variant SH3 domain Rapsyn_N PF10579.9 EMD61063.1 - 0.13 12.3 0.1 0.41 10.8 0.1 1.8 1 0 0 1 1 1 0 Rapsyn N-terminal myristoylation and linker region Not1 PF04054.15 EMD61064.1 - 6.3e-126 420.2 0.3 6.3e-126 420.2 0.3 2.0 2 0 0 2 2 2 1 CCR4-Not complex component, Not1 CNOT1_CAF1_bind PF16415.5 EMD61064.1 - 1.9e-93 312.0 0.1 4e-93 310.9 0.1 1.5 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 1 CAF1-binding domain DUF3819 PF12842.7 EMD61064.1 - 4.8e-48 162.8 3.8 1.3e-47 161.4 3.8 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF3819) CNOT1_TTP_bind PF16417.5 EMD61064.1 - 6.5e-45 152.6 0.0 1.6e-44 151.4 0.0 1.6 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 1 TTP binding domain CNOT1_HEAT PF16418.5 EMD61064.1 - 4.5e-30 104.7 0.2 1.5e-29 103.0 0.2 2.0 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 1 HEAT repeat IQ_SEC7_PH PF16453.5 EMD61064.1 - 0.015 15.2 0.9 0.29 11.1 0.1 3.0 3 0 0 3 3 3 0 PH domain Prion PF00377.18 EMD61064.1 - 0.061 13.2 0.6 0.14 12.0 0.1 1.8 2 0 0 2 2 2 0 Prion/Doppel alpha-helical domain DUF1835 PF08874.10 EMD61064.1 - 0.63 10.2 2.2 2 8.6 0.2 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1835) PHC2_SAM_assoc PF16616.5 EMD61065.1 - 5.8 7.8 12.0 7.9 7.3 11.5 1.4 1 1 0 1 1 1 0 Unstructured region on Polyhomeotic-like protein 1 and 2 Nucleo_P87 PF07267.11 EMD61068.1 - 0.41 9.4 7.0 0.46 9.3 7.0 1.0 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 PP28 PF10252.9 EMD61068.1 - 0.79 10.2 6.4 0.19 12.2 2.5 2.0 1 1 1 2 2 2 0 Casein kinase substrate phosphoprotein PP28 YrhK PF14145.6 EMD61069.1 - 0.034 14.0 24.8 1.3 9.0 2.9 4.5 3 2 0 3 3 3 0 YrhK-like protein Pkinase PF00069.25 EMD61071.1 - 1.4e-53 182.0 0.0 1.9e-53 181.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD61071.1 - 8.6e-33 113.7 0.0 1.1e-32 113.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EMD61071.1 - 9.9e-05 22.4 0.0 0.00046 20.2 0.0 1.9 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 EMD61071.1 - 0.00052 19.4 0.0 0.0011 18.4 0.0 1.5 1 1 1 2 2 2 1 Kinase-like Kdo PF06293.14 EMD61071.1 - 0.0039 16.6 0.0 0.0058 16.0 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EMD61071.1 - 0.19 10.6 0.1 1.4 7.8 0.0 1.9 2 0 0 2 2 2 0 Haspin like kinase domain Fungal_trans PF04082.18 EMD61074.1 - 1.2e-15 57.3 0.1 1.8e-15 56.7 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain FliS PF02561.14 EMD61074.1 - 0.045 14.0 0.1 0.1 12.9 0.1 1.5 1 0 0 1 1 1 0 Flagellar protein FliS Adaptin_N PF01602.20 EMD61075.1 - 5.4e-120 401.4 8.0 6.6e-120 401.1 8.0 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptin_C PF02296.16 EMD61075.1 - 4.7e-47 158.9 0.0 1.4e-46 157.3 0.0 1.9 2 0 0 2 2 2 1 Alpha adaptin AP2, C-terminal domain Alpha_adaptinC2 PF02883.20 EMD61075.1 - 3.1e-20 72.5 0.1 8.5e-20 71.1 0.1 1.8 1 0 0 1 1 1 1 Adaptin C-terminal domain Cnd1 PF12717.7 EMD61075.1 - 6.2e-05 23.1 1.7 0.072 13.1 0.0 2.9 1 1 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EMD61075.1 - 0.058 13.8 2.0 2.2 8.7 0.1 3.6 3 0 0 3 3 3 0 HEAT repeats Arm PF00514.23 EMD61077.1 - 0.0031 17.5 1.2 4.4 7.5 0.2 4.6 4 0 0 4 4 4 1 Armadillo/beta-catenin-like repeat DPM3 PF08285.11 EMD61078.1 - 8.6e-39 131.6 0.2 9.5e-39 131.5 0.2 1.0 1 0 0 1 1 1 1 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) DUF2523 PF10734.9 EMD61078.1 - 0.027 15.0 0.4 0.045 14.3 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2523) Phage_holin_3_6 PF07332.11 EMD61078.1 - 0.039 14.0 0.2 0.056 13.5 0.2 1.2 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III Oxidored-like PF09791.9 EMD61079.1 - 6.3e-26 89.8 4.6 1.4e-25 88.6 4.6 1.6 1 0 0 1 1 1 1 Oxidoreductase-like protein, N-terminal CCDC-167 PF15188.6 EMD61080.1 - 0.0075 16.6 2.7 0.019 15.3 2.7 1.6 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 167 DUF4238 PF14022.6 EMD61080.1 - 0.025 14.1 0.2 0.04 13.4 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4238) Ala_racemase_N PF01168.20 EMD61081.1 - 1.4e-24 87.0 0.0 1.7e-24 86.7 0.0 1.0 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain Aldose_epim PF01263.20 EMD61082.1 - 2e-44 152.1 0.4 2.3e-44 151.9 0.4 1.0 1 0 0 1 1 1 1 Aldose 1-epimerase MS_channel PF00924.18 EMD61086.1 - 6.5e-16 58.5 1.0 1.3e-15 57.5 1.0 1.4 1 0 0 1 1 1 1 Mechanosensitive ion channel EF-hand_1 PF00036.32 EMD61086.1 - 0.0015 17.9 0.2 0.0036 16.7 0.2 1.7 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 EMD61086.1 - 0.0065 16.9 0.0 0.015 15.8 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 EMD61086.1 - 0.02 14.4 0.0 0.048 13.2 0.0 1.6 1 0 0 1 1 1 0 EF hand EF-hand_6 PF13405.6 EMD61086.1 - 0.022 14.7 0.0 0.097 12.7 0.0 2.1 2 0 0 2 2 2 0 EF-hand domain HXXEE PF13787.6 EMD61086.1 - 0.046 14.5 4.9 0.93 10.3 0.6 2.5 2 0 0 2 2 2 0 Protein of unknown function with HXXEE motif ELH PF02323.15 EMD61087.1 - 0.063 12.6 0.0 0.099 12.0 0.0 1.2 1 0 0 1 1 1 0 Egg-laying hormone precursor PIG-Y PF15159.6 EMD61088.1 - 8.9e-23 81.0 8.3 1.8e-22 80.0 7.8 1.7 2 0 0 2 2 2 1 Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y DUF1218 PF06749.12 EMD61088.1 - 0.0049 17.4 2.9 0.95 10.0 0.3 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF1218) Cation_efflux PF01545.21 EMD61089.1 - 5.8e-09 36.0 10.5 7.6e-09 35.6 10.5 1.1 1 0 0 1 1 1 1 Cation efflux family IBR PF01485.21 EMD61090.1 - 6.2e-15 55.2 38.7 7.5e-09 35.7 9.4 3.3 3 0 0 3 3 3 3 IBR domain, a half RING-finger domain DUF2158 PF09926.9 EMD61090.1 - 0.00065 19.4 0.1 0.0016 18.2 0.1 1.6 1 0 0 1 1 1 1 Uncharacterized small protein (DUF2158) Cyclin_N PF00134.23 EMD61091.1 - 0.0054 16.5 0.0 0.13 12.0 0.0 2.4 2 1 0 2 2 2 1 Cyclin, N-terminal domain TFIIB PF00382.19 EMD61091.1 - 0.082 13.0 0.3 7.1 6.8 0.0 2.6 3 0 0 3 3 3 0 Transcription factor TFIIB repeat RAP PF08373.10 EMD61091.1 - 0.1 12.7 0.1 0.34 11.0 0.1 1.8 1 1 1 2 2 2 0 RAP domain Rab_eff_C PF04698.12 EMD61093.1 - 0.03 12.6 0.5 0.036 12.4 0.5 1.1 1 0 0 1 1 1 0 Rab effector MyRIP/melanophilin C-terminus DUF3136 PF11334.8 EMD61093.1 - 0.055 13.3 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3136) Hamartin PF04388.12 EMD61094.1 - 2.5 6.7 12.1 3.1 6.4 12.1 1.0 1 0 0 1 1 1 0 Hamartin protein Ish1 PF10281.9 EMD61095.1 - 1.7e-49 165.8 14.9 1.9e-14 53.7 0.0 5.3 5 0 0 5 5 5 4 Putative stress-responsive nuclear envelope protein Slx4 PF09494.10 EMD61095.1 - 0.0014 18.5 0.7 4.7 7.2 0.0 4.1 4 0 0 4 4 4 1 Slx4 endonuclease SAP PF02037.27 EMD61095.1 - 0.0089 15.8 0.0 3.6 7.5 0.0 3.6 4 0 0 4 4 4 1 SAP domain HeH PF12949.7 EMD61095.1 - 0.01 15.5 0.0 1.6 8.5 0.0 3.4 4 0 0 4 4 4 0 HeH/LEM domain Phage_holin_2_4 PF16082.5 EMD61096.1 - 0.0033 17.1 0.3 0.01 15.6 0.3 1.8 1 0 0 1 1 1 1 Bacteriophage holin family, superfamily II-like SR-25 PF10500.9 EMD61096.1 - 0.16 11.5 6.2 0.028 14.0 2.4 1.7 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Ogr_Delta PF04606.12 EMD61099.1 - 1.1 9.3 7.9 1.3 9.0 0.2 2.8 3 0 0 3 3 3 0 Ogr/Delta-like zinc finger p450 PF00067.22 EMD61101.1 - 1.2e-55 189.2 0.0 1.6e-55 188.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Phospho_p8 PF10195.9 EMD61101.1 - 0.16 12.5 0.1 0.5 10.9 0.1 1.8 1 0 0 1 1 1 0 DNA-binding nuclear phosphoprotein p8 DUF3433 PF11915.8 EMD61102.1 - 1.5e-42 143.9 19.4 4.9e-22 78.2 1.8 4.1 5 0 0 5 5 5 2 Protein of unknown function (DUF3433) Arf PF00025.21 EMD61103.1 - 2.3e-74 248.6 0.0 2.5e-74 248.5 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EMD61103.1 - 1.3e-14 54.4 0.0 1.7e-14 54.0 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EMD61103.1 - 2e-12 46.9 0.0 2.6e-12 46.5 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 EMD61103.1 - 3e-11 43.1 0.3 4.2e-07 29.4 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 EMD61103.1 - 1.5e-10 41.0 0.0 1.7e-10 40.7 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 EMD61103.1 - 7.3e-09 35.3 0.0 9.6e-09 34.9 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EMD61103.1 - 6.7e-07 29.4 0.0 1.1e-06 28.7 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EMD61103.1 - 0.00042 19.9 0.0 0.039 13.5 0.0 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 EMD61103.1 - 0.0063 16.1 0.7 0.026 14.1 0.7 2.0 1 1 0 1 1 1 1 Ferrous iron transport protein B AAA_18 PF13238.6 EMD61103.1 - 0.095 13.2 0.2 0.29 11.7 0.1 1.7 1 1 1 2 2 2 0 AAA domain p450 PF00067.22 EMD61105.1 - 3.3e-36 125.0 0.0 4.5e-36 124.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Sugar_tr PF00083.24 EMD61106.1 - 4.4e-127 424.7 21.8 5.1e-127 424.5 21.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD61106.1 - 1.2e-20 73.7 40.5 6.7e-18 64.7 16.2 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF5357 PF17310.2 EMD61106.1 - 1.3 7.5 6.6 0.59 8.6 0.2 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5357) DUF4064 PF13273.6 EMD61106.1 - 7.4 6.9 21.4 2.2 8.6 7.1 4.5 4 1 0 4 4 4 0 Protein of unknown function (DUF4064) MFS_1 PF07690.16 EMD61107.1 - 5e-41 140.8 72.3 3.2e-33 115.1 45.2 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EMD61107.1 - 0.0027 16.6 24.4 0.0093 14.9 6.2 2.4 2 0 0 2 2 2 2 Sugar (and other) transporter DUF1736 PF08409.11 EMD61108.1 - 0.041 13.9 0.8 0.075 13.0 0.6 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF1736) PSS PF03034.15 EMD61108.1 - 0.085 12.6 3.9 0.2 11.4 3.9 1.7 1 1 0 1 1 1 0 Phosphatidyl serine synthase Hva1_TUDOR PF11160.8 EMD61109.1 - 2.1e-16 59.8 1.9 2.1e-16 59.8 1.9 2.7 2 1 1 3 3 3 1 Hypervirulence associated proteins TUDOR domain HlyIII PF03006.20 EMD61110.1 - 4.1e-65 219.6 10.6 4.8e-65 219.4 10.6 1.0 1 0 0 1 1 1 1 Haemolysin-III related DUF962 PF06127.11 EMD61110.1 - 0.018 15.1 0.4 0.018 15.1 0.4 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF962) HisKA_7TM PF16927.5 EMD61110.1 - 0.036 14.1 10.8 0.068 13.2 10.8 1.6 1 1 0 1 1 1 0 N-terminal 7TM region of histidine kinase Bax1-I PF01027.20 EMD61110.1 - 0.13 12.1 12.6 0.92 9.3 3.2 2.6 1 1 1 2 2 2 0 Inhibitor of apoptosis-promoting Bax1 DUF4405 PF14358.6 EMD61110.1 - 0.21 12.1 13.4 0.72 10.4 0.3 3.1 3 1 0 3 3 3 0 Domain of unknown function (DUF4405) PsbN PF02468.15 EMD61110.1 - 0.28 11.1 2.6 0.84 9.5 0.5 2.5 2 0 0 2 2 2 0 Photosystem II reaction centre N protein (psbN) TssN PF17555.2 EMD61110.1 - 0.28 10.5 4.4 0.51 9.7 1.5 2.4 1 1 2 3 3 3 0 Type VI secretion system, TssN Phage_holin_5_2 PF16079.5 EMD61110.1 - 0.31 11.4 1.8 2.1 8.7 0.1 2.8 3 0 0 3 3 3 0 Phage holin family Hol44, in holin superfamily V DUF2157 PF09925.9 EMD61110.1 - 7.7 6.3 9.8 5.6 6.7 1.8 3.0 1 1 2 3 3 3 0 Predicted membrane protein (DUF2157) CSN8_PSD8_EIF3K PF10075.9 EMD61111.1 - 0.099 12.6 0.0 0.22 11.5 0.0 1.6 1 0 0 1 1 1 0 CSN8/PSMD8/EIF3K family Brix PF04427.18 EMD61112.1 - 1.9e-47 161.9 0.0 2.6e-47 161.4 0.0 1.1 1 0 0 1 1 1 1 Brix domain Menin PF05053.13 EMD61112.1 - 0.42 8.9 9.5 0.62 8.4 9.5 1.2 1 0 0 1 1 1 0 Menin DEAD PF00270.29 EMD61113.1 - 1.2e-47 162.0 0.0 1.8e-47 161.3 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EMD61113.1 - 5.2e-31 107.3 0.0 2.3e-30 105.2 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EMD61113.1 - 0.00039 20.5 0.0 0.00072 19.6 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EMD61113.1 - 0.00085 18.6 0.0 0.0015 17.8 0.0 1.3 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Pox_Ag35 PF03286.14 EMD61113.1 - 0.53 10.0 5.1 0.82 9.4 5.1 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Haem_degrading PF03928.14 EMD61114.1 - 2.7e-27 95.2 0.1 3.7e-27 94.7 0.1 1.1 1 0 0 1 1 1 1 Haem-degrading YAcAr PF10686.9 EMD61114.1 - 0.033 14.1 0.0 0.088 12.8 0.0 1.7 1 0 0 1 1 1 0 YspA, cpYpsA-related SLOG family Ferritin_2 PF13668.6 EMD61115.1 - 1.3e-15 57.8 0.0 1.8e-15 57.3 0.0 1.3 1 0 0 1 1 1 1 Ferritin-like domain TRM PF02005.16 EMD61116.1 - 2.1e-117 392.5 0.0 8.5e-102 341.1 0.0 2.0 1 1 1 2 2 2 2 N2,N2-dimethylguanosine tRNA methyltransferase Met_10 PF02475.16 EMD61116.1 - 1.2e-05 25.2 0.0 0.00014 21.7 0.0 2.1 2 0 0 2 2 2 1 Met-10+ like-protein MTS PF05175.14 EMD61116.1 - 0.034 13.7 0.0 0.066 12.8 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase small domain Cons_hypoth95 PF03602.15 EMD61116.1 - 0.035 13.7 0.0 0.089 12.4 0.0 1.6 2 0 0 2 2 2 0 Conserved hypothetical protein 95 Methyltransf_25 PF13649.6 EMD61116.1 - 0.18 12.5 0.0 0.7 10.6 0.0 2.1 1 0 0 1 1 1 0 Methyltransferase domain Auto_anti-p27 PF06677.12 EMD61116.1 - 4.8 7.4 6.2 0.91 9.7 0.1 2.6 3 0 0 3 3 3 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) HRI1 PF16815.5 EMD61118.1 - 1.7e-69 234.1 2.1 2.3e-69 233.6 2.1 1.1 1 0 0 1 1 1 1 Protein HRI1 SLAC1 PF03595.17 EMD61119.1 - 1e-82 278.0 45.8 1.2e-82 277.8 45.8 1.0 1 0 0 1 1 1 1 Voltage-dependent anion channel p450 PF00067.22 EMD61120.1 - 8.6e-70 235.8 0.0 1.1e-69 235.4 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 BioW PF03744.13 EMD61120.1 - 0.079 12.5 0.2 0.12 11.9 0.2 1.2 1 0 0 1 1 1 0 6-carboxyhexanoate--CoA ligase BTB PF00651.31 EMD61121.1 - 9.2e-07 29.1 0.0 1.5e-06 28.4 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain CIDR1_gamma PF18562.1 EMD61121.1 - 0.03 14.4 0.1 0.064 13.4 0.1 1.5 1 0 0 1 1 1 0 Cysteine-Rich Interdomain Region 1 gamma LD_cluster3 PF18180.1 EMD61121.1 - 0.13 11.9 0.0 2 8.0 0.0 2.0 2 0 0 2 2 2 0 SLOG cluster3 family TIMELESS PF04821.14 EMD61122.1 - 2.2e-80 269.9 0.0 6.7e-80 268.3 0.0 1.9 1 0 0 1 1 1 1 Timeless protein TIMELESS_C PF05029.13 EMD61122.1 - 1.5e-27 97.0 0.8 1.5e-27 97.0 0.8 4.6 3 1 1 4 4 4 1 Timeless protein C terminal region 3HCDH_N PF02737.18 EMD61123.1 - 6.1e-52 176.1 0.2 7.9e-52 175.7 0.2 1.1 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 EMD61123.1 - 1.7e-33 115.1 0.0 3.4e-33 114.1 0.0 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 EMD61123.1 - 0.0016 18.6 0.1 0.0035 17.5 0.1 1.6 1 1 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh_C PF02826.19 EMD61123.1 - 0.002 17.5 0.2 0.0081 15.5 0.1 2.0 1 1 1 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Sacchrp_dh_NADP PF03435.18 EMD61123.1 - 0.0048 17.2 0.1 0.0092 16.2 0.1 1.5 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain FeoC PF09012.10 EMD61123.1 - 0.01 15.9 0.1 2.7 8.1 0.0 3.1 3 0 0 3 3 3 0 FeoC like transcriptional regulator UDPG_MGDP_dh_N PF03721.14 EMD61123.1 - 0.037 13.6 0.0 0.067 12.8 0.0 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_Gly3P_dh_N PF01210.23 EMD61123.1 - 0.098 12.6 0.1 0.17 11.8 0.1 1.5 1 1 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus IHO1 PF15771.5 EMD61124.1 - 1.1 7.9 8.1 1.3 7.7 8.1 1.1 1 0 0 1 1 1 0 Interactor of HORMAD1 protein 1 Pex14_N PF04695.13 EMD61126.1 - 8e-42 143.6 0.8 8e-42 143.6 0.8 2.7 2 1 0 2 2 2 1 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF3584 PF12128.8 EMD61126.1 - 0.018 12.6 4.0 0.025 12.1 4.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Baculo_PEP_C PF04513.12 EMD61126.1 - 0.039 14.0 0.6 6.1 6.9 0.0 2.1 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1043 PF06295.12 EMD61126.1 - 0.068 13.2 1.9 0.12 12.3 0.5 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1043) EamA PF00892.20 EMD61126.1 - 0.21 11.7 0.0 0.33 11.1 0.0 1.2 1 0 0 1 1 1 0 EamA-like transporter family Golgin_A5 PF09787.9 EMD61126.1 - 0.23 10.9 2.0 0.36 10.3 2.0 1.2 1 0 0 1 1 1 0 Golgin subfamily A member 5 FAP PF07174.11 EMD61126.1 - 4 6.8 31.5 1.9 7.9 9.4 2.2 2 0 0 2 2 2 0 Fibronectin-attachment protein (FAP) CHZ PF09649.10 EMD61127.1 - 0.0089 15.5 6.2 0.017 14.6 6.2 1.5 1 0 0 1 1 1 1 Histone chaperone domain CHZ Cgr1 PF03879.14 EMD61128.1 - 0.0068 16.8 0.4 0.014 15.8 0.4 1.4 1 0 0 1 1 1 1 Cgr1 family DUF465 PF04325.13 EMD61128.1 - 0.031 14.3 1.5 0.066 13.3 1.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF465) DUF1189 PF06691.11 EMD61128.1 - 0.29 10.6 0.0 0.49 9.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1189) zf-PARP PF00645.18 EMD61129.1 - 3.3e-22 79.1 0.2 3.3e-22 79.1 0.2 2.1 2 0 0 2 2 2 1 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region Seipin PF06775.14 EMD61132.1 - 3.4e-57 193.8 0.0 4.3e-57 193.4 0.0 1.1 1 0 0 1 1 1 1 Putative adipose-regulatory protein (Seipin) Abhydrolase_3 PF07859.13 EMD61133.1 - 1e-39 136.6 0.1 2.3e-39 135.4 0.1 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Arm-DNA-bind_3 PF13356.6 EMD61133.1 - 0.11 12.9 0.6 9 6.8 0.0 2.7 2 0 0 2 2 2 0 Arm DNA-binding domain Say1_Mug180 PF10340.9 EMD61133.1 - 0.26 10.1 0.0 2.6 6.8 0.0 2.2 2 0 0 2 2 2 0 Steryl acetyl hydrolase SPR1 PF15356.6 EMD61133.1 - 1 9.9 7.0 6.2 7.4 2.2 2.7 1 1 1 2 2 2 0 Psoriasis susceptibility locus 2 Cyclin_N PF00134.23 EMD61134.1 - 2.6e-14 53.1 0.2 7.1e-14 51.7 0.1 1.7 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 EMD61134.1 - 5.2e-05 23.3 0.7 0.0027 17.8 0.0 2.7 2 1 0 2 2 2 1 Cyclin, C-terminal domain TFIIB PF00382.19 EMD61134.1 - 0.00026 21.0 0.2 0.5 10.5 0.0 2.4 2 0 0 2 2 2 2 Transcription factor TFIIB repeat UPF0016 PF01169.19 EMD61135.1 - 6.1e-41 138.6 25.6 5.4e-21 74.7 11.7 2.2 2 0 0 2 2 2 2 Uncharacterized protein family UPF0016 Mntp PF02659.15 EMD61135.1 - 0.027 14.2 0.1 0.027 14.2 0.1 2.2 2 0 0 2 2 2 0 Putative manganese efflux pump DUF3357 PF11837.8 EMD61135.1 - 1.4 9.4 7.7 18 5.8 0.3 3.0 2 1 0 2 2 2 0 Domain of unknown function (DUF3357) SCNM1_acidic PF15805.5 EMD61136.1 - 0.032 13.9 0.1 0.13 12.1 0.1 2.1 1 0 0 1 1 1 0 Acidic C-terminal region of sodium channel modifier 1 SCNM1 Myb_DNA-binding PF00249.31 EMD61136.1 - 0.1 12.8 0.0 0.24 11.6 0.0 1.7 1 0 0 1 1 1 0 Myb-like DNA-binding domain DUF2256 PF10013.9 EMD61137.1 - 3.1e-05 24.0 3.0 3.1e-05 24.0 3.0 1.9 2 0 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2256) zf-MYND PF01753.18 EMD61137.1 - 0.44 10.7 4.2 1.4 9.1 4.2 1.8 1 0 0 1 1 1 0 MYND finger Fumble PF03630.14 EMD61138.1 - 4.4e-142 473.1 0.0 5.7e-142 472.8 0.0 1.1 1 0 0 1 1 1 1 Fumble Ank_2 PF12796.7 EMD61140.1 - 4.6e-18 65.6 1.7 3.1e-11 43.7 0.1 2.9 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMD61140.1 - 7.4e-11 42.4 0.2 1.8e-08 34.8 0.0 2.8 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 EMD61140.1 - 2.8e-10 40.2 2.4 0.0053 17.1 0.0 4.3 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.6 EMD61140.1 - 2.6e-07 30.4 0.5 0.3 11.8 0.0 4.4 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 EMD61140.1 - 6.1e-06 26.4 0.3 0.019 15.3 0.0 3.5 1 1 2 3 3 3 1 Ankyrin repeats (many copies) HET PF06985.11 EMD61141.1 - 2.5e-25 89.5 0.5 4.1e-25 88.8 0.5 1.3 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) APH PF01636.23 EMD61142.1 - 7e-08 32.7 0.1 1.9e-07 31.3 0.1 2.0 1 1 0 1 1 1 1 Phosphotransferase enzyme family F_bP_aldolase PF01116.20 EMD61143.1 - 8.1e-98 327.3 0.0 9.2e-98 327.2 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II Ribosomal_L9_N PF01281.19 EMD61144.1 - 4.4e-09 35.8 0.0 9.9e-09 34.6 0.0 1.7 1 0 0 1 1 1 1 Ribosomal protein L9, N-terminal domain Ribosomal_L9_C PF03948.14 EMD61144.1 - 7e-05 23.2 0.0 0.00027 21.3 0.0 2.0 1 1 0 1 1 1 1 Ribosomal protein L9, C-terminal domain UCH PF00443.29 EMD61145.1 - 3.7e-37 128.2 0.0 1.5e-31 109.8 0.0 2.1 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EMD61145.1 - 5.1e-07 29.6 2.0 0.022 14.3 1.1 3.2 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase GFO_IDH_MocA PF01408.22 EMD61146.1 - 2.8e-12 47.5 0.0 7.3e-12 46.2 0.0 1.7 1 1 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 EMD61146.1 - 0.0026 17.7 1.7 0.0031 17.5 0.0 2.1 2 0 0 2 2 2 1 Oxidoreductase family, C-terminal alpha/beta domain IBN_N PF03810.19 EMD61149.1 - 4.5e-16 58.5 0.1 3.6e-12 46.0 0.0 3.0 2 0 0 2 2 2 2 Importin-beta N-terminal domain Cse1 PF08506.10 EMD61149.1 - 1.2e-06 27.7 0.4 3.6e-06 26.1 0.1 2.0 2 0 0 2 2 2 1 Cse1 Xpo1 PF08389.12 EMD61149.1 - 0.0042 17.2 2.0 1.3 9.1 0.0 4.0 3 0 0 3 3 3 1 Exportin 1-like protein RTP1_C1 PF10363.9 EMD61149.1 - 0.065 13.4 0.1 0.27 11.4 0.1 2.1 1 0 0 1 1 1 0 Required for nuclear transport of RNA pol II C-terminus 1 DCB PF16213.5 EMD61149.1 - 0.11 12.1 0.1 0.31 10.7 0.1 1.7 1 0 0 1 1 1 0 Dimerisation and cyclophilin-binding domain of Mon2 HEAT PF02985.22 EMD61149.1 - 0.17 12.2 0.8 6.3 7.3 0.0 3.7 3 0 0 3 3 3 0 HEAT repeat SDA1 PF05285.12 EMD61149.1 - 6.9 6.0 11.5 11 5.4 11.5 1.2 1 0 0 1 1 1 0 SDA1 NRBF2 PF08961.10 EMD61150.1 - 0.062 12.9 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 Nuclear receptor-binding factor 2, autophagy regulator FAT PF02259.23 EMD61151.1 - 5.3e-117 390.9 5.0 5.3e-117 390.9 5.0 1.8 2 0 0 2 2 2 1 FAT domain PI3_PI4_kinase PF00454.27 EMD61151.1 - 1e-71 241.7 1.6 1.1e-71 241.5 0.1 1.8 2 0 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase DUF3385 PF11865.8 EMD61151.1 - 2.3e-65 219.4 0.7 1.5e-58 197.3 0.1 6.0 3 2 1 4 4 4 1 Domain of unknown function (DUF3385) FRB_dom PF08771.11 EMD61151.1 - 5.1e-43 145.5 0.0 5.1e-43 145.5 0.0 4.4 4 1 1 5 5 4 1 FKBP12-rapamycin binding domain FATC PF02260.20 EMD61151.1 - 4.2e-16 58.5 0.1 1.2e-15 57.0 0.1 1.9 1 0 0 1 1 1 1 FATC domain HEAT PF02985.22 EMD61151.1 - 7.2e-12 44.5 18.8 0.077 13.3 0.0 11.4 13 0 0 13 13 11 3 HEAT repeat HEAT_2 PF13646.6 EMD61151.1 - 7.3e-11 42.3 11.9 0.0083 16.5 0.0 10.1 8 2 2 10 10 10 3 HEAT repeats HEAT_EZ PF13513.6 EMD61151.1 - 1.2e-07 32.0 20.1 0.0077 16.7 0.0 10.4 10 1 2 12 12 10 1 HEAT-like repeat Vac14_Fab1_bd PF12755.7 EMD61151.1 - 4.6e-07 30.3 0.0 2.7 8.6 0.0 6.6 6 0 0 6 6 6 1 Vacuolar 14 Fab1-binding region Tti2 PF10521.9 EMD61151.1 - 2.2e-06 27.5 0.3 0.25 10.9 0.1 4.0 3 1 0 3 3 3 2 Tti2 family Cnd1 PF12717.7 EMD61151.1 - 4e-06 27.0 1.3 5.2 7.1 0.0 5.9 5 1 0 6 6 6 1 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 EMD61151.1 - 3.1e-05 22.8 3.6 1.4 7.4 0.0 5.7 5 2 0 7 7 7 2 Adaptin N terminal region IFRD PF05004.13 EMD61151.1 - 3.1e-05 23.2 0.1 0.38 9.8 0.0 3.9 4 0 0 4 4 4 2 Interferon-related developmental regulator (IFRD) Sec7_N PF12783.7 EMD61151.1 - 0.00053 19.9 0.0 4.1 7.3 0.1 4.2 4 0 0 4 4 3 2 Guanine nucleotide exchange factor in Golgi transport N-terminal TAF6_C PF07571.13 EMD61151.1 - 0.00096 19.4 0.0 2.6 8.4 0.0 5.0 6 0 0 6 6 4 1 TAF6 C-terminal HEAT repeat domain DUF3730 PF12530.8 EMD61151.1 - 0.0019 17.8 0.1 9.2 5.8 0.0 4.9 2 1 1 3 3 3 0 Protein of unknown function (DUF3730) TPR_19 PF14559.6 EMD61151.1 - 0.0039 17.7 0.1 12 6.5 0.0 4.3 3 0 0 3 3 3 0 Tetratricopeptide repeat HEAT_PBS PF03130.16 EMD61151.1 - 0.012 16.2 3.4 1.2e+02 3.8 0.0 6.7 5 0 0 5 5 5 0 PBS lyase HEAT-like repeat CLASP_N PF12348.8 EMD61151.1 - 0.023 14.3 0.7 50 3.3 0.0 5.3 5 1 1 6 6 5 0 CLASP N terminal ANAPC3 PF12895.7 EMD61151.1 - 0.12 12.6 1.6 7.8 6.8 0.0 3.0 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.6 EMD61151.1 - 0.26 12.0 6.5 1.8 9.3 0.0 3.8 4 0 0 4 4 2 0 Tetratricopeptide repeat DUF2115 PF09888.9 EMD61151.1 - 0.26 11.8 0.8 1.4 9.5 0.1 2.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2115) TPR_1 PF00515.28 EMD61151.1 - 0.38 10.7 3.0 22 5.1 0.3 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 EMD61151.1 - 7.2 7.0 10.2 5 7.5 0.2 4.0 4 0 0 4 4 3 0 Tetratricopeptide repeat TauD PF02668.16 EMD61152.1 - 3.4e-36 125.4 0.0 5.3e-36 124.8 0.0 1.3 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF971 PF06155.12 EMD61152.1 - 4.4e-13 49.7 0.0 2.7e-09 37.5 0.0 2.9 2 1 1 3 3 3 2 Protein of unknown function (DUF971) CsiD PF08943.10 EMD61152.1 - 0.091 11.9 0.0 0.58 9.2 0.0 1.9 2 0 0 2 2 2 0 CsiD NADH-u_ox-rdase PF10785.9 EMD61153.1 - 1.6e-27 96.0 0.3 2.7e-27 95.3 0.3 1.4 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit NADH_u_ox_C PF12853.7 EMD61153.1 - 1.5e-23 82.5 0.1 2.4e-23 81.9 0.1 1.3 1 0 0 1 1 1 1 C-terminal of NADH-ubiquinone oxidoreductase 21 kDa subunit Aquarius_N PF16399.5 EMD61154.1 - 0 1080.9 0.1 0 1080.6 0.1 1.1 1 0 0 1 1 1 1 Intron-binding protein aquarius N-terminus AAA_12 PF13087.6 EMD61154.1 - 6.8e-29 100.9 0.0 1.1e-28 100.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 EMD61154.1 - 3.9e-21 76.0 0.0 2.1e-20 73.6 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EMD61154.1 - 5.4e-06 26.3 0.0 0.0017 18.1 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.6 EMD61154.1 - 7.8e-06 26.3 0.0 1.7e-05 25.2 0.0 1.7 1 1 0 1 1 1 1 AAA domain ResIII PF04851.15 EMD61154.1 - 2e-05 24.7 0.0 4.4e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DnaB_C PF03796.15 EMD61154.1 - 0.0017 17.8 0.0 0.003 16.9 0.0 1.3 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain AAA_16 PF13191.6 EMD61154.1 - 0.0047 17.3 0.0 0.019 15.4 0.0 2.0 1 0 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 EMD61154.1 - 0.0054 17.1 0.0 0.015 15.7 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_topoisoIV PF00521.20 EMD61154.1 - 0.019 13.8 0.1 0.031 13.2 0.1 1.2 1 0 0 1 1 1 0 DNA gyrase/topoisomerase IV, subunit A DUF2075 PF09848.9 EMD61154.1 - 0.021 14.1 0.3 0.057 12.6 0.0 1.8 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_22 PF13401.6 EMD61154.1 - 0.031 14.6 0.3 0.33 11.2 0.1 2.7 2 1 0 2 2 2 0 AAA domain UvrD-helicase PF00580.21 EMD61154.1 - 0.087 12.3 0.0 0.28 10.6 0.0 1.9 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain AAA_5 PF07728.14 EMD61154.1 - 0.098 12.7 0.0 0.32 11.0 0.0 1.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Tfb2 PF03849.14 EMD61155.1 - 1.2e-134 448.8 0.1 2.3e-134 447.9 0.0 1.4 2 0 0 2 2 2 1 Transcription factor Tfb2 Tfb2_C PF18307.1 EMD61155.1 - 4.2e-20 71.9 0.1 8.3e-20 71.0 0.1 1.5 1 0 0 1 1 1 1 Transcription factor Tfb2 (p52) C-terminal domain Helicase_C_3 PF13625.6 EMD61155.1 - 0.00024 21.3 0.0 0.00074 19.7 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain 4HBT PF03061.22 EMD61156.1 - 1.9e-13 50.6 0.0 2.6e-13 50.1 0.0 1.2 1 0 0 1 1 1 1 Thioesterase superfamily DUF4442 PF14539.6 EMD61156.1 - 0.033 14.3 0.0 0.045 13.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4442) NB-ARC PF00931.22 EMD61158.1 - 5e-06 25.9 0.0 9.3e-06 25.0 0.0 1.4 1 1 0 1 1 1 1 NB-ARC domain NACHT PF05729.12 EMD61158.1 - 0.00019 21.4 0.1 0.0012 18.8 0.1 2.1 1 1 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 EMD61158.1 - 0.0011 19.3 0.0 0.0019 18.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 EMD61158.1 - 0.0015 18.5 0.0 0.0025 17.8 0.0 1.3 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_16 PF13191.6 EMD61158.1 - 0.0082 16.5 0.1 0.024 15.0 0.1 1.7 1 1 0 1 1 1 1 AAA ATPase domain Zeta_toxin PF06414.12 EMD61158.1 - 0.052 12.8 0.0 0.088 12.1 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin ATPase PF06745.13 EMD61158.1 - 0.085 12.2 0.0 0.38 10.1 0.0 1.9 2 1 0 2 2 2 0 KaiC MobB PF03205.14 EMD61158.1 - 0.16 11.8 0.0 3.5 7.5 0.0 2.2 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B Patatin PF01734.22 EMD61159.1 - 2.1e-16 60.7 0.0 2.9e-16 60.3 0.0 1.2 1 0 0 1 1 1 1 Patatin-like phospholipase Pkinase PF00069.25 EMD61160.1 - 1.3e-09 37.9 0.0 4.6e-09 36.0 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD61160.1 - 1.7e-05 24.3 0.0 9.4e-05 21.8 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase AAA PF00004.29 EMD61161.1 - 2.2e-40 138.2 0.0 4.2e-40 137.2 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 EMD61161.1 - 2.9e-19 68.8 0.3 5.7e-19 67.8 0.3 1.5 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 EMD61161.1 - 6.2e-09 35.5 0.0 1.3e-08 34.5 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 EMD61161.1 - 9.3e-05 22.4 0.1 0.00053 20.0 0.1 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EMD61161.1 - 0.00013 22.4 1.5 0.02 15.3 0.0 3.0 2 1 1 3 3 3 1 AAA ATPase domain RuvB_N PF05496.12 EMD61161.1 - 0.00029 20.6 0.0 0.00073 19.3 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 EMD61161.1 - 0.0012 19.0 0.1 0.011 15.8 0.0 2.6 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 EMD61161.1 - 0.0013 19.1 1.8 0.082 13.2 0.0 3.1 2 1 1 3 3 3 1 AAA domain JIP_LZII PF16471.5 EMD61161.1 - 0.0028 17.8 3.0 0.008 16.3 3.0 1.8 1 0 0 1 1 1 1 JNK-interacting protein leucine zipper II Mg_chelatase PF01078.21 EMD61161.1 - 0.007 15.8 0.1 0.02 14.3 0.0 1.7 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI PhoH PF02562.16 EMD61161.1 - 0.0077 15.7 1.3 0.08 12.4 0.1 2.5 3 0 0 3 3 3 1 PhoH-like protein CLZ PF16526.5 EMD61161.1 - 0.0081 16.5 4.5 0.043 14.2 4.5 2.4 1 0 0 1 1 1 1 C-terminal leucine zipper domain of cyclic nucleotide-gated channels AAA_33 PF13671.6 EMD61161.1 - 0.011 15.9 0.0 0.034 14.3 0.0 1.9 2 0 0 2 2 2 0 AAA domain DUF815 PF05673.13 EMD61161.1 - 0.015 14.5 0.7 0.031 13.5 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF815) IstB_IS21 PF01695.17 EMD61161.1 - 0.076 12.7 0.1 0.18 11.5 0.1 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_24 PF13479.6 EMD61161.1 - 0.1 12.3 1.0 0.26 11.0 0.0 2.3 2 1 0 2 2 2 0 AAA domain AAA_7 PF12775.7 EMD61161.1 - 0.12 11.9 0.0 0.37 10.3 0.0 1.9 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_11 PF13086.6 EMD61161.1 - 7.5 6.3 9.5 0.88 9.3 0.1 2.9 2 2 0 3 3 3 0 AAA domain DUF3419 PF11899.8 EMD61162.1 - 1.1e-148 495.6 0.0 1.4e-148 495.2 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3419) Methyltransf_23 PF13489.6 EMD61162.1 - 3.3e-11 43.3 0.0 7.6e-10 38.9 0.0 2.4 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMD61162.1 - 1.9e-07 31.7 0.0 1.2e-05 25.9 0.0 3.5 3 1 1 4 4 4 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMD61162.1 - 3.6e-07 30.8 0.0 3.2e-06 27.8 0.0 2.6 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMD61162.1 - 2.1e-05 25.1 0.0 0.0013 19.4 0.0 3.5 4 0 0 4 4 4 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMD61162.1 - 9.5e-05 22.2 0.0 0.00031 20.6 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain PCMT PF01135.19 EMD61162.1 - 0.0024 17.7 0.0 0.0045 16.8 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Ubie_methyltran PF01209.18 EMD61162.1 - 0.0099 15.2 0.0 0.05 12.9 0.0 2.0 1 1 1 2 2 2 1 ubiE/COQ5 methyltransferase family Ost5 PF05251.12 EMD61162.1 - 0.017 15.3 0.1 0.048 13.9 0.1 1.7 1 0 0 1 1 1 0 Oligosaccharyltransferase subunit 5 Methyltransf_32 PF13679.6 EMD61162.1 - 0.12 12.4 0.0 0.23 11.4 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Rer1 PF03248.13 EMD61163.1 - 4.3e-77 257.7 1.6 4.9e-77 257.5 1.6 1.0 1 0 0 1 1 1 1 Rer1 family ECH_1 PF00378.20 EMD61164.1 - 2.5e-73 246.5 0.3 3e-73 246.2 0.3 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EMD61164.1 - 8.9e-33 114.2 0.2 1.9e-30 106.5 0.1 2.0 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase Ferric_reduct PF01794.19 EMD61165.1 - 3.7e-18 65.8 11.3 3.7e-18 65.8 11.3 2.3 2 0 0 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 EMD61165.1 - 4.6e-08 33.1 0.0 1.5e-07 31.4 0.0 1.9 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.12 EMD61165.1 - 1.2e-07 32.0 0.0 0.022 14.9 0.0 2.5 1 1 1 2 2 2 2 Ferric reductase NAD binding domain DUF1331 PF07048.11 EMD61166.1 - 0.12 12.1 0.5 0.2 11.4 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1331) DSHCT PF08148.12 EMD61167.1 - 2.3e-50 170.5 0.6 2.3e-50 170.5 0.6 1.7 2 0 0 2 2 2 1 DSHCT (NUC185) domain Ski2_N PF17911.1 EMD61167.1 - 1.6e-41 141.3 0.1 3e-41 140.4 0.1 1.5 1 0 0 1 1 1 1 Ski2 N-terminal region rRNA_proc-arch PF13234.6 EMD61167.1 - 4.4e-21 76.0 0.4 7.6e-21 75.2 0.4 1.4 1 0 0 1 1 1 1 rRNA-processing arch domain DEAD PF00270.29 EMD61167.1 - 6.9e-19 68.3 0.1 3.6e-18 65.9 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EMD61167.1 - 4.1e-07 30.3 0.0 1.4e-06 28.6 0.0 2.0 1 1 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EMD61167.1 - 6.3e-06 26.3 0.1 3e-05 24.1 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Swi3 PF07962.12 EMD61168.1 - 2.2e-30 104.5 0.1 3.1e-30 104.0 0.1 1.2 1 0 0 1 1 1 1 Replication Fork Protection Component Swi3 TMEM247 PF15444.6 EMD61168.1 - 0.023 14.8 0.9 0.038 14.1 0.9 1.3 1 0 0 1 1 1 0 Transmembrane protein 247 efThoc1 PF11957.8 EMD61169.1 - 3.3e-122 408.7 0.4 4.1e-122 408.3 0.4 1.0 1 0 0 1 1 1 1 THO complex subunit 1 transcription elongation factor Homeodomain PF00046.29 EMD61170.1 - 2.9e-17 62.2 3.5 5e-17 61.5 3.5 1.4 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EMD61170.1 - 0.025 14.5 0.1 0.051 13.5 0.1 1.5 1 0 0 1 1 1 0 Homeobox KN domain MIF4G PF02854.19 EMD61173.1 - 1.5e-50 171.8 0.0 1.5e-50 171.8 0.0 1.9 2 0 0 2 2 2 1 MIF4G domain eIF_4G1 PF12152.8 EMD61173.1 - 6.5e-23 80.7 0.5 6.5e-23 80.7 0.5 2.3 2 0 0 2 2 2 1 Eukaryotic translation initiation factor 4G1 CCDC14 PF15254.6 EMD61173.1 - 0.00013 20.8 15.6 0.00013 20.8 15.6 2.5 2 1 1 3 3 3 1 Coiled-coil domain-containing protein 14 Chlorosome_CsmC PF11098.8 EMD61174.1 - 0.053 13.5 7.2 0.069 13.1 7.2 1.1 1 0 0 1 1 1 0 Chlorosome envelope protein C adh_short PF00106.25 EMD61175.1 - 7.9e-35 120.1 0.1 1.1e-34 119.7 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD61175.1 - 2.1e-25 89.7 0.1 6.9e-25 88.0 0.1 1.7 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD61175.1 - 5.5e-11 42.7 0.1 8.3e-11 42.1 0.1 1.2 1 0 0 1 1 1 1 KR domain ATP-grasp_2 PF08442.10 EMD61176.1 - 6e-76 254.5 0.5 1.1e-75 253.7 0.5 1.4 1 0 0 1 1 1 1 ATP-grasp domain Ligase_CoA PF00549.19 EMD61176.1 - 2.1e-25 89.4 0.6 3.8e-25 88.5 0.6 1.5 1 0 0 1 1 1 1 CoA-ligase ATP-grasp_5 PF13549.6 EMD61176.1 - 4.1e-10 39.5 0.2 9.9e-10 38.2 0.2 1.7 1 0 0 1 1 1 1 ATP-grasp domain GARS_A PF01071.19 EMD61176.1 - 0.0079 16.0 1.4 0.13 12.0 0.2 2.4 2 1 0 2 2 2 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain VID27_N PF17748.1 EMD61176.1 - 0.14 12.0 1.3 0.29 10.9 1.3 1.4 1 0 0 1 1 1 0 VID27 N-terminal region DUF3245 PF11595.8 EMD61177.1 - 3.1e-10 40.7 6.6 3.1e-10 40.7 6.6 2.8 1 1 2 3 3 3 1 Protein of unknown function (DUF3245) Podoplanin PF05808.11 EMD61177.1 - 0.2 11.8 7.0 11 6.1 0.0 2.1 1 1 1 2 2 2 0 Podoplanin Thiolase_N PF00108.23 EMD61178.1 - 8.3e-75 251.5 1.2 1.1e-74 251.1 1.2 1.1 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EMD61178.1 - 7.3e-42 141.9 0.4 2e-41 140.5 0.3 1.8 2 0 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 EMD61178.1 - 0.0015 18.2 0.7 0.0035 17.0 0.7 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain NTF2 PF02136.20 EMD61179.1 - 1.1e-32 113.1 0.2 1.3e-32 112.9 0.2 1.0 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain DUF4440 PF14534.6 EMD61179.1 - 0.00015 22.1 0.0 0.00018 21.9 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) SnoaL_2 PF12680.7 EMD61179.1 - 0.057 14.1 0.0 0.07 13.8 0.0 1.1 1 0 0 1 1 1 0 SnoaL-like domain Epimerase PF01370.21 EMD61180.1 - 5.5e-19 68.6 0.0 7.5e-19 68.1 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EMD61180.1 - 1.3e-13 50.6 0.0 1.9e-13 50.0 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 EMD61180.1 - 6.2e-10 38.7 0.0 3.8e-09 36.1 0.0 1.9 1 1 0 1 1 1 1 Male sterility protein GDP_Man_Dehyd PF16363.5 EMD61180.1 - 4.1e-08 33.0 0.1 3e-07 30.2 0.0 2.0 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase NmrA PF05368.13 EMD61180.1 - 8e-06 25.6 0.7 0.075 12.6 0.0 2.2 2 0 0 2 2 2 2 NmrA-like family NAD_binding_10 PF13460.6 EMD61180.1 - 0.00013 21.9 0.1 0.00056 19.8 0.0 2.0 2 1 0 2 2 2 1 NAD(P)H-binding KR PF08659.10 EMD61180.1 - 0.00027 20.9 0.0 0.00051 20.0 0.0 1.4 1 0 0 1 1 1 1 KR domain adh_short PF00106.25 EMD61180.1 - 0.00038 20.0 0.1 0.0038 16.7 0.0 2.2 2 0 0 2 2 2 1 short chain dehydrogenase F420_oxidored PF03807.17 EMD61180.1 - 0.025 15.2 0.0 0.092 13.3 0.0 1.9 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent Sacchrp_dh_NADP PF03435.18 EMD61180.1 - 0.049 13.9 0.0 0.089 13.1 0.0 1.5 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Meth_synt_2 PF01717.18 EMD61181.1 - 1.5e-13 50.7 0.0 3.9e-08 32.9 0.0 2.8 2 1 0 2 2 2 2 Cobalamin-independent synthase, Catalytic domain Meth_synt_1 PF08267.12 EMD61181.1 - 0.0012 18.4 0.0 0.0042 16.7 0.0 1.9 3 0 0 3 3 3 1 Cobalamin-independent synthase, N-terminal domain CKS PF01111.19 EMD61181.1 - 0.0052 17.0 0.0 0.036 14.3 0.0 2.2 2 0 0 2 2 2 1 Cyclin-dependent kinase regulatory subunit GMC_oxred_C PF05199.13 EMD61182.1 - 1.6e-31 109.8 0.1 2.4e-31 109.2 0.1 1.3 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_N PF00732.19 EMD61182.1 - 2.7e-30 105.8 0.0 1.5e-27 96.8 0.0 2.3 1 1 1 2 2 2 2 GMC oxidoreductase NAD_binding_8 PF13450.6 EMD61182.1 - 0.0006 20.0 0.1 0.0015 18.7 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EMD61182.1 - 0.0035 16.6 0.0 0.0059 15.9 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EMD61182.1 - 0.0045 16.1 0.2 0.017 14.2 0.3 1.8 2 0 0 2 2 2 1 FAD binding domain Lycopene_cycl PF05834.12 EMD61182.1 - 0.09 11.8 0.0 0.13 11.3 0.0 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein ApbA PF02558.16 EMD61182.1 - 0.16 11.6 0.3 0.3 10.7 0.3 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA ThiF PF00899.21 EMD61182.1 - 0.24 10.7 0.7 0.48 9.7 0.7 1.4 1 0 0 1 1 1 0 ThiF family TauD PF02668.16 EMD61183.1 - 4.4e-51 174.2 0.0 6.1e-51 173.8 0.0 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family MFS_1 PF07690.16 EMD61184.1 - 1.2e-20 73.8 18.2 1.6e-20 73.3 18.2 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Varsurf_PPLC PF03490.13 EMD61184.1 - 0.078 12.9 0.5 0.36 10.8 0.3 2.1 2 0 0 2 2 2 0 Variant-surface-glycoprotein phospholipase C Aldo_ket_red PF00248.21 EMD61185.1 - 4.9e-70 236.0 0.0 5.5e-70 235.9 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family LPD22 PF18834.1 EMD61185.1 - 0.2 11.9 0.0 0.54 10.5 0.0 1.7 1 0 0 1 1 1 0 Large polyvalent protein associated domain 22 Ank_2 PF12796.7 EMD61186.1 - 1.4e-13 51.2 0.5 0.00056 20.4 0.0 3.7 2 1 1 4 4 4 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMD61186.1 - 1.6e-09 38.1 0.0 0.016 15.8 0.0 4.4 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMD61186.1 - 2e-07 30.7 0.2 1.4 9.7 0.0 5.2 5 0 0 5 5 5 2 Ankyrin repeat Ank_5 PF13857.6 EMD61186.1 - 1.7e-06 28.2 0.1 0.069 13.5 0.0 4.6 2 1 3 5 5 5 3 Ankyrin repeats (many copies) CorA PF01544.18 EMD61186.1 - 0.0008 18.8 0.0 0.0018 17.7 0.0 1.5 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein SUR7 PF06687.12 EMD61186.1 - 0.097 12.3 0.1 0.15 11.6 0.1 1.2 1 0 0 1 1 1 0 SUR7/PalI family CASP_C PF08172.12 EMD61186.1 - 0.13 11.6 0.5 0.19 11.0 0.5 1.2 1 0 0 1 1 1 0 CASP C terminal AATase PF07247.12 EMD61187.1 - 2.2e-22 79.3 0.0 1.1e-16 60.6 0.0 2.5 2 1 0 2 2 2 2 Alcohol acetyltransferase Condensation PF00668.20 EMD61187.1 - 0.011 14.5 0.3 0.021 13.5 0.0 1.5 2 0 0 2 2 2 0 Condensation domain WES_acyltransf PF03007.16 EMD61187.1 - 0.073 12.8 0.0 0.11 12.2 0.0 1.2 1 0 0 1 1 1 0 Wax ester synthase-like Acyl-CoA acyltransferase domain LPD38 PF18857.1 EMD61187.1 - 0.15 12.2 0.1 0.39 10.9 0.0 1.6 2 0 0 2 2 2 0 Large polyvalent protein associated domain 38 DUF1996 PF09362.10 EMD61188.1 - 7.5e-82 274.8 0.5 9.2e-82 274.5 0.5 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1996) BRD4_CDT PF17105.5 EMD61189.1 - 5.6 6.6 7.3 4 7.1 0.0 3.0 3 0 0 3 3 3 0 C-terminal domain of bromodomain protein 4 zf-C2H2_jaz PF12171.8 EMD61190.1 - 7e-06 26.2 0.5 1.1e-05 25.6 0.5 1.3 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EMD61190.1 - 0.0014 18.9 0.0 0.0026 18.1 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2 PF00096.26 EMD61190.1 - 0.0029 18.0 0.5 0.0029 18.0 0.5 2.1 2 0 0 2 2 2 1 Zinc finger, C2H2 type CCSAP PF15748.5 EMD61190.1 - 0.027 14.6 0.1 0.038 14.2 0.1 1.2 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated DUF5447 PF17525.2 EMD61190.1 - 0.076 13.5 0.1 0.19 12.3 0.1 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5447) zf-C2H2_4 PF13894.6 EMD61190.1 - 0.14 13.1 0.1 0.14 13.1 0.1 2.0 2 0 0 2 2 2 0 C2H2-type zinc finger DUF1691 PF07950.11 EMD61191.1 - 3.3e-33 114.6 4.4 7.3e-28 97.4 2.1 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF1691) TTL PF03133.15 EMD61192.1 - 5.1e-45 153.9 0.0 4.9e-28 98.1 0.0 2.3 2 0 0 2 2 2 2 Tubulin-tyrosine ligase family zf-primase PF09329.11 EMD61192.1 - 5.5e-18 64.5 2.0 9.4e-18 63.8 2.0 1.4 1 0 0 1 1 1 1 Primase zinc finger tRNA_anti-codon PF01336.25 EMD61192.1 - 0.084 12.9 0.0 0.19 11.8 0.0 1.5 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain RNase_H2-Ydr279 PF09468.10 EMD61193.1 - 6.7e-45 153.1 0.6 6.7e-45 153.1 0.6 1.8 2 0 0 2 2 2 1 Ydr279p protein family (RNase H2 complex component) wHTH domain Ydr279_N PF17745.1 EMD61193.1 - 7.2e-26 90.3 0.0 3.3e-25 88.1 0.0 2.2 2 0 0 2 2 2 1 Ydr279p protein triple barrel domain DUF2589 PF11655.8 EMD61194.1 - 0.37 11.1 4.0 0.12 12.7 0.8 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2589) DASH_Duo1 PF08651.10 EMD61195.1 - 8.6e-32 108.8 3.0 1.2e-31 108.3 3.0 1.2 1 0 0 1 1 1 1 DASH complex subunit Duo1 DASH_Dad2 PF08654.10 EMD61195.1 - 0.022 15.1 6.7 0.045 14.2 6.7 1.6 1 1 0 1 1 1 0 DASH complex subunit Dad2 DUF745 PF05335.13 EMD61195.1 - 0.036 13.8 16.8 0.058 13.1 16.5 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF745) DUF5082 PF16888.5 EMD61195.1 - 2.4 8.4 12.0 0.22 11.8 3.6 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF5082) API5 PF05918.11 EMD61195.1 - 3.8 6.2 12.3 4.3 6.0 11.7 1.3 1 1 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) 3HCDH_N PF02737.18 EMD61195.1 - 8.1 6.3 10.5 0.28 11.0 1.7 2.0 1 1 1 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GalKase_gal_bdg PF10509.9 EMD61196.1 - 7.7e-21 73.4 0.1 1.4e-20 72.6 0.1 1.5 1 0 0 1 1 1 1 Galactokinase galactose-binding signature GHMP_kinases_N PF00288.26 EMD61196.1 - 1.7e-15 57.0 2.7 4.1e-15 55.8 2.7 1.6 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 EMD61196.1 - 2.5e-14 53.4 0.0 5.9e-14 52.2 0.0 1.5 1 0 0 1 1 1 1 GHMP kinases C terminal Zn_clus PF00172.18 EMD61198.1 - 5.7e-08 32.8 9.3 1.3e-07 31.6 9.3 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Ribosomal_L13e PF01294.18 EMD61199.1 - 4.8e-77 257.9 4.7 7e-77 257.3 4.7 1.2 1 0 0 1 1 1 1 Ribosomal protein L13e LRR_4 PF12799.7 EMD61200.1 - 1e-32 111.6 34.3 3.3e-06 27.3 0.8 9.6 5 2 5 11 11 11 11 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EMD61200.1 - 1.7e-29 101.4 37.0 1.4e-06 28.0 2.9 8.0 3 3 6 9 9 9 9 Leucine rich repeat LRR_9 PF14580.6 EMD61200.1 - 7.3e-06 25.6 14.8 0.72 9.3 0.9 5.1 2 2 2 5 5 5 5 Leucine-rich repeat LRR_6 PF13516.6 EMD61200.1 - 2.2e-05 24.1 23.8 0.45 10.7 0.0 9.9 11 0 0 11 11 11 2 Leucine Rich repeat LRR_1 PF00560.33 EMD61200.1 - 0.0072 16.7 23.5 24 6.0 0.5 9.8 11 0 0 11 11 11 2 Leucine Rich Repeat bZIP_1 PF00170.21 EMD61201.1 - 0.026 14.6 6.1 0.48 10.5 0.9 2.9 2 1 1 3 3 3 0 bZIP transcription factor Exonuc_VII_L PF02601.15 EMD61201.1 - 1.7 8.1 9.7 3.8 7.0 9.7 1.6 1 0 0 1 1 1 0 Exonuclease VII, large subunit bZIP_2 PF07716.15 EMD61201.1 - 3.2 7.9 8.5 32 4.7 3.1 3.1 1 1 1 2 2 2 0 Basic region leucine zipper FliD_N PF02465.18 EMD61202.1 - 0.028 15.1 1.7 0.075 13.7 1.7 1.8 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus Polo_box_3 PF18544.1 EMD61202.1 - 0.6 10.8 5.2 17 6.2 0.1 3.3 2 1 1 3 3 3 0 Polo box domain DUF3323 PF11796.8 EMD61203.1 - 0.32 10.9 3.6 5.4 6.8 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function N-terminus (DUF3323) Hid1 PF12722.7 EMD61203.1 - 3.8 5.5 11.4 0.059 11.5 1.0 2.0 2 0 0 2 2 2 0 High-temperature-induced dauer-formation protein zinc_ribbon_10 PF10058.9 EMD61204.1 - 6.8e-20 70.6 0.1 1.3e-19 69.7 0.1 1.5 1 0 0 1 1 1 1 Predicted integral membrane zinc-ribbon metal-binding protein MAS20 PF02064.15 EMD61204.1 - 0.076 13.1 0.3 0.18 11.9 0.3 1.6 1 0 0 1 1 1 0 MAS20 protein import receptor Complex1_LYR PF05347.15 EMD61205.1 - 1.5e-06 28.2 0.3 2.6e-06 27.4 0.3 1.3 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 EMD61205.1 - 0.029 15.1 0.6 0.037 14.8 0.6 1.3 1 1 0 1 1 1 0 Complex1_LYR-like RRM_1 PF00076.22 EMD61206.1 - 6.3e-08 32.3 0.0 1e-07 31.7 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EMD61206.1 - 0.00094 19.1 0.0 0.0017 18.3 0.0 1.4 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 EMD61206.1 - 0.0034 17.2 0.0 0.0055 16.5 0.0 1.3 1 0 0 1 1 1 1 Occluded RNA-recognition motif RRM_3 PF08777.11 EMD61206.1 - 0.016 15.2 0.0 0.041 13.9 0.0 1.6 1 0 0 1 1 1 0 RNA binding motif Sterol_MT_C PF08498.10 EMD61207.1 - 3.3e-30 104.2 0.2 6.1e-30 103.3 0.2 1.4 1 0 0 1 1 1 1 Sterol methyltransferase C-terminal Methyltransf_11 PF08241.12 EMD61207.1 - 6.4e-21 74.8 0.0 1.2e-20 73.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMD61207.1 - 4.4e-19 69.0 0.0 8e-19 68.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMD61207.1 - 6.8e-17 61.7 0.0 1e-16 61.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EMD61207.1 - 4.1e-13 49.3 0.2 5.7e-13 48.8 0.2 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.6 EMD61207.1 - 6.1e-12 45.7 0.0 9.8e-12 45.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EMD61207.1 - 7.8e-10 38.5 0.0 1.3e-09 37.8 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 EMD61207.1 - 2.2e-09 38.0 0.1 6e-09 36.6 0.0 1.8 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_29 PF03141.16 EMD61207.1 - 2.8e-05 22.9 0.0 4e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase RrnaAD PF00398.20 EMD61207.1 - 6.7e-05 22.1 0.0 9.7e-05 21.6 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase PCMT PF01135.19 EMD61207.1 - 0.00059 19.7 0.0 0.0014 18.4 0.0 1.6 2 0 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_2 PF00891.18 EMD61207.1 - 0.0012 18.2 0.0 0.0022 17.3 0.0 1.5 1 0 0 1 1 1 1 O-methyltransferase domain MetW PF07021.12 EMD61207.1 - 0.0015 18.2 0.0 0.0024 17.5 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW MTS PF05175.14 EMD61207.1 - 0.0018 17.9 0.0 0.0034 17.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 EMD61207.1 - 0.0029 17.0 0.1 0.0099 15.3 0.0 1.8 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_15 PF09445.10 EMD61207.1 - 0.0053 16.3 0.0 0.0081 15.8 0.0 1.3 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_32 PF13679.6 EMD61207.1 - 0.0058 16.6 0.4 0.014 15.4 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain TehB PF03848.14 EMD61207.1 - 0.0076 15.7 0.0 0.015 14.7 0.0 1.5 1 0 0 1 1 1 1 Tellurite resistance protein TehB VAPB_antitox PF02697.14 EMD61207.1 - 0.11 13.3 0.3 0.29 11.9 0.3 1.6 1 0 0 1 1 1 0 Putative antitoxin Transket_pyr PF02779.24 EMD61208.1 - 1.1e-48 165.3 0.0 1.6e-48 164.7 0.0 1.2 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 EMD61208.1 - 4.7e-34 116.9 0.0 1.3e-33 115.5 0.0 1.8 1 0 0 1 1 1 1 Transketolase, C-terminal domain Zn_ribbon_17 PF17120.5 EMD61209.1 - 0.011 15.3 1.8 0.018 14.6 1.8 1.3 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type DUF4079 PF13301.6 EMD61210.1 - 0.17 12.0 0.2 0.17 12.0 0.2 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF4079) Aldo_ket_red PF00248.21 EMD61211.1 - 1.4e-57 195.2 0.0 1.8e-57 194.8 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Aldedh PF00171.22 EMD61212.1 - 9.8e-159 528.7 0.0 1.1e-158 528.5 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family GMC_oxred_N PF00732.19 EMD61213.1 - 2e-49 168.6 0.0 2.8e-49 168.1 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EMD61213.1 - 1.3e-37 129.5 0.0 1.9e-37 128.9 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase Lycopene_cycl PF05834.12 EMD61213.1 - 4e-06 26.1 0.0 5.6e-06 25.6 0.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein NAD_binding_8 PF13450.6 EMD61213.1 - 4.2e-05 23.7 0.0 0.00014 22.0 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 EMD61213.1 - 0.0001 22.7 0.1 0.11 13.1 0.0 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EMD61213.1 - 0.00018 20.8 0.0 0.1 11.7 0.0 2.3 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.24 EMD61213.1 - 0.00024 20.8 0.0 0.0029 17.3 0.0 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EMD61213.1 - 0.0015 17.8 0.0 0.01 15.1 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EMD61213.1 - 0.015 14.6 0.1 0.063 12.5 0.0 2.0 2 0 0 2 2 2 0 Thi4 family Trp_halogenase PF04820.14 EMD61213.1 - 0.016 14.1 0.0 0.023 13.6 0.0 1.2 1 0 0 1 1 1 0 Tryptophan halogenase FAD_oxidored PF12831.7 EMD61213.1 - 0.079 12.3 0.0 3.8 6.7 0.0 2.3 2 0 0 2 2 2 0 FAD dependent oxidoreductase HI0933_like PF03486.14 EMD61213.1 - 0.21 10.3 0.0 0.38 9.4 0.0 1.4 1 0 0 1 1 1 0 HI0933-like protein BUD22 PF09073.10 EMD61214.1 - 6.2 6.0 15.2 0.45 9.8 5.6 2.0 2 0 0 2 2 2 0 BUD22 WD40 PF00400.32 EMD61216.1 - 2.4e-71 233.9 24.7 9.7e-12 45.2 0.1 7.2 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD61216.1 - 2.3e-24 85.5 4.6 0.0076 16.5 0.1 6.7 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain NACHT PF05729.12 EMD61216.1 - 6.2e-14 52.2 1.3 3.5e-12 46.5 1.3 2.5 1 1 0 1 1 1 1 NACHT domain Nup160 PF11715.8 EMD61216.1 - 6.3e-12 44.9 13.8 0.39 9.3 0.1 6.1 2 1 4 6 6 6 6 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 EMD61216.1 - 1.5e-10 40.6 16.1 0.0014 17.7 1.5 5.1 1 1 3 4 4 4 4 WD40 region of Ge1, enhancer of mRNA-decapping protein BLUF PF04940.12 EMD61216.1 - 3.8e-06 27.0 0.0 40 4.4 0.0 5.8 5 0 0 5 5 5 0 Sensors of blue-light using FAD Frtz PF11768.8 EMD61216.1 - 1.2e-05 23.9 0.7 0.17 10.2 0.0 3.1 1 1 4 5 5 5 4 WD repeat-containing and planar cell polarity effector protein Fritz CDtoxinA PF03498.14 EMD61216.1 - 0.00055 19.5 0.0 1.1 8.8 0.0 3.4 1 1 3 4 4 4 2 Cytolethal distending toxin A/C domain SRP9-21 PF05486.12 EMD61216.1 - 0.00057 20.2 0.3 96 3.5 0.0 6.1 6 1 0 6 6 6 0 Signal recognition particle 9 kDa protein (SRP9) TsaE PF02367.17 EMD61216.1 - 0.0013 18.7 0.0 0.0028 17.6 0.0 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE RNA_helicase PF00910.22 EMD61216.1 - 0.01 16.2 0.1 0.031 14.6 0.1 1.8 1 0 0 1 1 1 0 RNA helicase Antifungal_pept PF11410.8 EMD61216.1 - 0.019 14.9 4.7 82 3.2 0.0 5.6 6 0 0 6 6 6 0 Antifungal peptide Peptidase_M7 PF02031.16 EMD61216.1 - 0.13 12.4 1.6 72 3.5 0.0 4.4 1 1 5 6 6 6 0 Streptomyces extracellular neutral proteinase (M7) family Helo_like_N PF17111.5 EMD61217.1 - 1.4e-30 106.3 4.4 1.7e-30 106.0 4.4 1.1 1 0 0 1 1 1 1 Fungal N-terminal domain of STAND proteins SesA PF17107.5 EMD61217.1 - 0.00093 19.4 0.1 0.00093 19.4 0.1 2.0 2 1 0 2 2 2 1 N-terminal domain on NACHT_NTPase and P-loop NTPases HSBP1 PF06825.12 EMD61217.1 - 0.011 15.6 0.1 0.044 13.7 0.1 2.0 2 0 0 2 2 2 0 Heat shock factor binding protein 1 Baculo_PEP_C PF04513.12 EMD61217.1 - 0.052 13.6 2.0 2.2 8.3 0.3 2.4 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1664 PF07889.12 EMD61217.1 - 0.49 10.4 4.5 3.4 7.7 1.5 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) Syntaxin_2 PF14523.6 EMD61217.1 - 3.9 7.9 9.2 16 5.9 3.3 2.5 1 1 2 3 3 3 0 Syntaxin-like protein HET PF06985.11 EMD61219.1 - 3.8e-30 105.2 0.0 2.7e-29 102.4 0.0 2.4 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Dabb PF07876.12 EMD61221.1 - 3.4e-11 43.6 0.0 1.6e-10 41.5 0.0 1.8 1 1 0 1 1 1 1 Stress responsive A/B Barrel Domain CFC PF09443.10 EMD61222.1 - 0.092 12.6 0.0 0.21 11.5 0.0 1.6 1 0 0 1 1 1 0 Cripto_Frl-1_Cryptic (CFC) XPG_I_2 PF12813.7 EMD61224.1 - 2.9e-48 164.5 0.3 2.9e-48 164.5 0.3 1.6 2 0 0 2 2 2 1 XPG domain containing XPG_N PF00752.17 EMD61224.1 - 0.0021 18.5 0.0 0.0082 16.6 0.0 2.1 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 EMD61224.1 - 0.07 13.5 0.7 0.15 12.4 0.0 1.9 2 0 0 2 2 2 0 XPG I-region Coilin_N PF15862.5 EMD61224.1 - 0.19 11.5 4.5 0.072 12.9 1.5 1.8 2 0 0 2 2 2 0 Coilin N-terminus PGM_PMM_I PF02878.16 EMD61225.1 - 1.6e-33 115.3 0.0 2.4e-33 114.8 0.0 1.3 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.16 EMD61225.1 - 2.5e-26 92.1 0.0 4.5e-26 91.3 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 EMD61225.1 - 6.9e-15 55.5 0.1 1.5e-14 54.5 0.1 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.20 EMD61225.1 - 4.3e-09 36.4 0.0 1.4e-08 34.8 0.0 1.8 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain Oxysterol_BP PF01237.18 EMD61226.1 - 8.6e-67 225.6 9.6 1.1e-64 218.7 9.6 2.0 1 1 0 1 1 1 1 Oxysterol-binding protein AbiGi PF10899.8 EMD61226.1 - 0.071 13.0 0.7 0.12 12.2 0.7 1.3 1 0 0 1 1 1 0 Putative abortive phage resistance protein AbiGi, antitoxin DUF4558 PF15104.6 EMD61226.1 - 0.18 11.9 4.3 0.055 13.5 1.2 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4558) BPL_N PF09825.9 EMD61227.1 - 3.9e-146 487.0 0.0 4.8e-146 486.7 0.0 1.1 1 0 0 1 1 1 1 Biotin-protein ligase, N terminal BPL_LplA_LipB PF03099.19 EMD61227.1 - 1.3e-22 80.1 0.0 2.8e-22 79.0 0.0 1.6 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family BPL_C PF02237.17 EMD61227.1 - 2.5e-05 24.1 0.0 6.4e-05 22.8 0.0 1.8 1 0 0 1 1 1 1 Biotin protein ligase C terminal domain ThuA PF06283.11 EMD61227.1 - 0.0022 18.3 0.0 0.056 13.7 0.0 2.6 2 1 0 2 2 2 1 Trehalose utilisation MRP-L28 PF09812.9 EMD61228.1 - 8.6e-06 26.0 0.2 1.3e-05 25.4 0.2 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L28 Ras PF00071.22 EMD61229.1 - 4.8e-48 162.8 0.0 5.6e-48 162.6 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMD61229.1 - 3.6e-22 78.8 0.0 5.6e-22 78.2 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMD61229.1 - 1e-07 31.6 0.0 1.3e-07 31.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EMD61229.1 - 0.0098 15.3 0.0 0.015 14.8 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 EMD61229.1 - 0.017 14.5 0.0 0.022 14.1 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EMD61229.1 - 0.11 12.6 0.0 0.2 11.7 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase PduV-EutP PF10662.9 EMD61229.1 - 0.11 12.2 0.0 2.5 7.8 0.0 2.2 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation ADH_zinc_N PF00107.26 EMD61229.1 - 0.17 11.9 0.0 5.5 7.0 0.0 2.2 2 0 0 2 2 2 0 Zinc-binding dehydrogenase AAA_21 PF13304.6 EMD61229.1 - 0.21 11.3 0.0 0.28 10.9 0.0 1.2 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system Baculo_11_kDa PF06143.11 EMD61230.1 - 0.044 13.4 4.0 0.06 12.9 4.0 1.2 1 0 0 1 1 1 0 Baculovirus 11 kDa family Zn_peptidase PF04228.13 EMD61230.1 - 0.19 11.2 1.9 0.2 11.1 1.9 1.1 1 0 0 1 1 1 0 Putative neutral zinc metallopeptidase Gram_pos_anchor PF00746.21 EMD61230.1 - 0.6 10.1 0.2 0.6 10.1 0.2 2.4 2 0 0 2 2 2 0 LPXTG cell wall anchor motif HemY_N PF07219.13 EMD61230.1 - 3.2 8.0 8.9 0.79 9.9 4.4 1.9 2 0 0 2 2 2 0 HemY protein N-terminus NICE-3 PF07406.11 EMD61230.1 - 9.6 6.2 7.5 12 5.8 7.5 1.1 1 0 0 1 1 1 0 NICE-3 protein NST1 PF13945.6 EMD61231.1 - 9.9e-56 188.9 19.8 9.9e-56 188.9 19.8 5.0 3 2 2 5 5 5 1 Salt tolerance down-regulator TFIIA PF03153.13 EMD61231.1 - 1.1e-05 25.6 23.3 1.1e-05 25.6 23.3 4.2 2 1 2 4 4 4 1 Transcription factor IIA, alpha/beta subunit PGM_PMM_I PF02878.16 EMD61232.1 - 6.9e-20 71.2 0.0 4.6e-09 36.1 0.0 2.9 1 1 1 2 2 2 2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_IV PF00408.20 EMD61232.1 - 1.2e-10 41.3 3.2 3e-09 36.9 0.8 3.2 3 0 0 3 3 3 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain PGM_PMM_III PF02880.16 EMD61232.1 - 0.00031 20.9 0.1 0.0007 19.8 0.1 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 EMD61232.1 - 0.0081 16.8 1.9 0.48 11.1 0.2 4.2 3 2 1 4 4 4 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II RSN1_7TM PF02714.15 EMD61233.1 - 7.7e-78 261.6 23.6 1.4e-77 260.7 23.6 1.5 1 0 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate PHM7_cyt PF14703.6 EMD61233.1 - 1.1e-40 139.7 0.1 1.8e-40 139.0 0.1 1.3 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter RSN1_TM PF13967.6 EMD61233.1 - 8.2e-38 129.6 2.4 8.2e-38 129.6 2.4 2.2 2 0 0 2 2 2 1 Late exocytosis, associated with Golgi transport UPF0242 PF06785.11 EMD61233.1 - 0.081 13.0 0.3 7.1 6.7 0.0 2.4 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Tox-REase-7 PF15649.6 EMD61233.1 - 0.089 13.1 0.2 0.24 11.7 0.0 1.8 2 0 0 2 2 2 0 Restriction endonuclease fold toxin 7 DUF3087 PF11286.8 EMD61233.1 - 3 7.3 5.6 1.9 8.0 0.2 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3087) PhoR PF11808.8 EMD61233.1 - 4.7 7.7 5.8 3.4 8.1 0.5 3.4 3 0 0 3 3 3 0 Phosphate regulon sensor protein PhoR DAGK_cat PF00781.24 EMD61235.1 - 8.3e-09 35.1 0.0 1.4e-08 34.4 0.0 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain Asp PF00026.23 EMD61236.1 - 6.8e-36 124.3 0.1 8e-36 124.0 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EMD61236.1 - 9.4e-06 26.0 0.2 0.00036 20.8 0.2 2.5 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal Asp PF00026.23 EMD61237.1 - 2.1e-49 168.7 0.2 2.4e-49 168.5 0.2 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EMD61237.1 - 0.015 15.6 0.1 0.84 9.8 0.0 2.5 1 1 1 2 2 2 0 Xylanase inhibitor N-terminal DUF3443 PF11925.8 EMD61237.1 - 0.016 14.0 0.5 2.5 6.8 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3443) PepSY_TM PF03929.16 EMD61238.1 - 0.024 14.3 0.4 0.035 13.8 0.2 1.4 1 1 0 1 1 1 0 PepSY-associated TM region DUF5567 PF17722.1 EMD61239.1 - 0.051 13.5 0.0 0.7 9.7 0.0 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5567) Peptidase_S49_N PF08496.10 EMD61239.1 - 0.63 10.1 2.2 1 9.4 2.2 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Asp PF00026.23 EMD61240.1 - 2.7e-09 36.9 0.0 3.9e-09 36.4 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease Ifi-6-16 PF06140.13 EMD61241.1 - 0.0009 19.1 16.8 0.0023 17.8 16.8 1.6 1 0 0 1 1 1 1 Interferon-induced 6-16 family Piwi PF02171.17 EMD61242.1 - 1.5e-70 237.8 0.0 3.8e-70 236.5 0.0 1.7 1 1 0 1 1 1 1 Piwi domain ArgoL1 PF08699.10 EMD61242.1 - 5.2e-16 58.0 0.3 1.2e-15 56.9 0.3 1.7 1 0 0 1 1 1 1 Argonaute linker 1 domain ArgoN PF16486.5 EMD61242.1 - 1.2e-15 58.4 0.5 2.1e-15 57.5 0.5 1.4 1 0 0 1 1 1 1 N-terminal domain of argonaute ArgoL2 PF16488.5 EMD61242.1 - 3.9e-10 39.9 0.0 1.1e-09 38.5 0.0 1.9 1 0 0 1 1 1 1 Argonaute linker 2 domain PAZ PF02170.22 EMD61242.1 - 1e-09 38.3 0.0 2.1e-09 37.3 0.0 1.5 1 0 0 1 1 1 1 PAZ domain ArgoMid PF16487.5 EMD61242.1 - 0.055 13.7 0.0 0.12 12.6 0.0 1.6 1 0 0 1 1 1 0 Mid domain of argonaute Acetyltransf_3 PF13302.7 EMD61243.1 - 8.4e-17 62.1 0.0 1e-16 61.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EMD61243.1 - 5.1e-07 29.9 0.1 9.8e-07 29.0 0.1 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 EMD61243.1 - 6.9e-05 22.7 0.1 0.00018 21.4 0.0 1.6 2 0 0 2 2 2 1 FR47-like protein Acetyltransf_7 PF13508.7 EMD61243.1 - 0.0043 17.5 0.4 0.0097 16.3 0.3 1.7 1 1 1 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EMD61243.1 - 0.008 16.1 0.0 0.011 15.6 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 EMD61243.1 - 0.018 14.7 0.0 0.029 14.1 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Transp_cyt_pur PF02133.15 EMD61244.1 - 3.1e-47 161.4 25.7 3.2e-19 69.0 3.6 3.9 1 1 2 3 3 3 3 Permease for cytosine/purines, uracil, thiamine, allantoin DUF21 PF01595.20 EMD61244.1 - 0.34 10.6 3.1 0.4 10.4 1.7 1.8 1 1 0 1 1 1 0 Cyclin M transmembrane N-terminal domain E1-E2_ATPase PF00122.20 EMD61245.1 - 1.6e-47 161.4 4.0 1.6e-47 161.4 4.0 2.5 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 EMD61245.1 - 9.9e-20 71.7 0.1 1.9e-19 70.8 0.1 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HMA PF00403.26 EMD61245.1 - 5.5e-07 29.9 0.3 1.8e-06 28.3 0.0 2.1 2 0 0 2 2 2 1 Heavy-metal-associated domain Hydrolase_3 PF08282.12 EMD61245.1 - 3.9e-05 23.5 0.2 0.00056 19.7 0.1 2.4 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase ECH_1 PF00378.20 EMD61247.1 - 8.2e-66 221.9 0.1 1e-65 221.6 0.1 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EMD61247.1 - 1.6e-30 106.8 0.5 3.6e-28 99.0 0.2 2.0 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase AMP-binding PF00501.28 EMD61248.1 - 2.5e-84 283.3 0.0 3.8e-84 282.7 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EMD61248.1 - 0.0011 19.9 0.0 0.0034 18.3 0.0 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain DUF908 PF06012.12 EMD61248.1 - 0.039 13.4 0.0 0.058 12.8 0.0 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) SdpI PF13630.6 EMD61248.1 - 1.7 8.8 8.0 0.33 11.1 1.1 2.8 2 0 0 2 2 2 0 SdpI/YhfL protein family Ferric_reduct PF01794.19 EMD61248.1 - 2.2 8.4 14.9 0.13 12.4 9.0 2.0 2 0 0 2 2 2 0 Ferric reductase like transmembrane component Glycos_transf_2 PF00535.26 EMD61249.1 - 2.3e-34 118.6 0.0 2.8e-34 118.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 EMD61249.1 - 1.8e-13 50.9 0.0 2.2e-13 50.6 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 EMD61249.1 - 0.00016 21.3 0.0 0.00021 20.9 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 EMD61249.1 - 0.00016 21.2 0.0 0.00025 20.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 21 DUF4978 PF16349.5 EMD61249.1 - 0.05 13.2 0.0 0.083 12.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4978) Hydrolase_like PF13242.6 EMD61250.1 - 1e-05 25.5 0.0 2.9e-05 24.0 0.0 1.7 2 0 0 2 2 2 1 HAD-hyrolase-like HAD_2 PF13419.6 EMD61250.1 - 0.0072 16.4 0.0 0.17 12.0 0.0 2.4 2 1 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Snurportin1 PF11538.8 EMD61251.1 - 0.3 11.3 3.4 0.76 10.0 3.4 1.7 1 0 0 1 1 1 0 Snurportin1 Surp PF01805.20 EMD61252.1 - 5.8e-11 42.2 0.1 1.2e-10 41.2 0.1 1.6 1 0 0 1 1 1 1 Surp module TPR_19 PF14559.6 EMD61254.1 - 2.9e-13 50.1 6.4 1.2e-08 35.4 0.2 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 EMD61254.1 - 1.5e-08 35.1 5.2 5.8e-05 23.7 0.1 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 EMD61254.1 - 6.6e-08 32.7 7.3 0.034 15.0 0.6 5.6 2 1 3 5 5 5 2 Tetratricopeptide repeat TPR_6 PF13174.6 EMD61254.1 - 1.6e-05 25.2 0.2 0.34 11.7 0.1 4.2 5 0 0 5 5 4 2 Tetratricopeptide repeat Coatomer_E PF04733.14 EMD61254.1 - 8e-05 22.2 0.3 0.00012 21.7 0.3 1.2 1 0 0 1 1 1 1 Coatomer epsilon subunit PknG_TPR PF16918.5 EMD61254.1 - 0.00068 18.5 0.7 0.0013 17.5 0.1 1.9 2 0 0 2 2 2 1 Protein kinase G tetratricopeptide repeat TPR_2 PF07719.17 EMD61254.1 - 0.0016 18.4 2.6 26 5.2 0.0 5.5 7 0 0 7 7 6 0 Tetratricopeptide repeat HrpB1_HrpK PF09613.10 EMD61254.1 - 0.0071 16.0 3.1 2.1 8.0 0.2 3.3 1 1 2 3 3 3 2 Bacterial type III secretion protein (HrpB1_HrpK) TPR_9 PF13371.6 EMD61254.1 - 0.0096 16.0 7.9 0.33 11.1 0.1 3.7 2 1 2 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 EMD61254.1 - 0.034 14.5 0.3 0.034 14.5 0.3 3.7 4 1 0 5 5 3 0 Tetratricopeptide repeat TPR_17 PF13431.6 EMD61254.1 - 0.055 13.9 0.1 0.36 11.3 0.1 2.5 1 0 0 1 1 1 0 Tetratricopeptide repeat ArnB_C PF18677.1 EMD61254.1 - 0.11 12.6 0.1 0.23 11.6 0.1 1.5 1 0 0 1 1 1 0 Archaellum regulatory network B, C-terminal domain TPR_20 PF14561.6 EMD61254.1 - 0.19 12.1 5.7 0.77 10.1 0.2 3.5 3 1 2 5 5 5 0 Tetratricopeptide repeat TPR_21 PF09976.9 EMD61254.1 - 0.2 11.4 6.7 7.7 6.2 0.2 3.2 2 1 0 3 3 3 0 Tetratricopeptide repeat-like domain TPP_enzyme_N PF02776.18 EMD61255.1 - 1.5e-54 184.1 0.1 3.3e-54 183.1 0.1 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 EMD61255.1 - 4.1e-47 159.8 0.0 4.4e-46 156.4 0.0 2.5 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 EMD61255.1 - 2.9e-41 140.4 1.0 5e-41 139.6 0.2 1.8 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain POR_N PF01855.19 EMD61255.1 - 0.033 13.9 0.1 0.064 13.0 0.1 1.4 1 0 0 1 1 1 0 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg Glyco_hydro_16 PF00722.21 EMD61256.1 - 1.8e-40 138.3 4.9 1.8e-40 138.3 4.9 1.5 2 0 0 2 2 2 1 Glycosyl hydrolases family 16 Mucin PF01456.17 EMD61256.1 - 0.074 13.0 13.9 0.15 12.0 13.9 1.5 1 0 0 1 1 1 0 Mucin-like glycoprotein LYRIC PF15686.5 EMD61256.1 - 1.3 8.5 11.3 2.2 7.7 11.3 1.3 1 0 0 1 1 1 0 Lysine-rich CEACAM1 co-isolated protein family Pkinase PF00069.25 EMD61257.1 - 4.8e-39 134.3 0.1 3e-22 79.2 0.1 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EMD61257.1 - 5e-14 52.2 0.5 1.1e-09 38.0 0.1 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 EMD61257.1 - 0.057 12.2 0.1 0.097 11.4 0.1 1.4 1 0 0 1 1 1 0 Fungal protein kinase SP_C-Propep PF08999.10 EMD61258.1 - 0.59 10.0 4.3 0.45 10.3 3.2 1.5 1 1 0 1 1 1 0 Surfactant protein C, N terminal propeptide IFT57 PF10498.9 EMD61259.1 - 3.4e-06 26.3 41.1 3.4e-06 26.3 41.1 3.8 3 1 1 4 4 4 1 Intra-flagellar transport protein 57 Tropomyosin PF00261.20 EMD61259.1 - 2.7e-05 23.7 33.1 2.7e-05 23.7 33.1 4.5 4 1 2 6 6 5 2 Tropomyosin FPP PF05911.11 EMD61259.1 - 0.00024 19.5 43.4 0.00024 19.5 43.4 3.4 2 1 1 3 3 3 1 Filament-like plant protein, long coiled-coil KxDL PF10241.9 EMD61259.1 - 0.00073 19.8 53.2 0.052 13.8 2.4 6.1 3 1 3 6 6 6 4 Uncharacterized conserved protein APG6_N PF17675.1 EMD61259.1 - 0.0017 18.9 94.4 0.0036 17.8 9.0 5.9 2 1 1 4 4 4 3 Apg6 coiled-coil region DHR10 PF18595.1 EMD61259.1 - 0.0066 16.5 15.7 0.0066 16.5 15.7 5.4 4 1 1 5 5 5 2 Designed helical repeat protein 10 domain Phage_GP20 PF06810.11 EMD61259.1 - 0.0079 16.0 70.5 0.014 15.2 8.4 5.5 3 1 2 5 5 5 3 Phage minor structural protein GP20 TPR_MLP1_2 PF07926.12 EMD61259.1 - 0.014 15.5 25.1 0.014 15.5 25.1 6.0 4 1 2 6 6 6 0 TPR/MLP1/MLP2-like protein DUF4201 PF13870.6 EMD61259.1 - 0.1 12.3 65.8 0.15 11.8 24.5 4.5 3 1 1 4 4 4 0 Domain of unknown function (DUF4201) Spc7 PF08317.11 EMD61259.1 - 0.15 10.9 79.6 0.12 11.2 6.9 4.4 2 1 2 4 4 4 0 Spc7 kinetochore protein GAS PF13851.6 EMD61259.1 - 0.18 11.1 75.7 0.72 9.2 11.3 5.0 2 1 1 4 4 4 0 Growth-arrest specific micro-tubule binding Fib_alpha PF08702.10 EMD61259.1 - 0.42 10.8 50.0 0.52 10.5 1.5 4.6 2 1 1 4 4 4 0 Fibrinogen alpha/beta chain family EzrA PF06160.12 EMD61259.1 - 0.54 8.4 64.1 0.19 9.9 2.5 4.1 2 1 2 4 4 4 0 Septation ring formation regulator, EzrA TolA_bind_tri PF16331.5 EMD61259.1 - 0.6 10.2 41.9 2.6 8.2 4.8 6.1 3 1 3 6 6 6 0 TolA binding protein trimerisation ADIP PF11559.8 EMD61259.1 - 1.2 9.2 75.3 0.15 12.1 4.2 5.9 5 1 1 6 6 6 0 Afadin- and alpha -actinin-Binding KASH_CCD PF14662.6 EMD61259.1 - 4.4 7.1 70.1 0.064 13.1 36.5 4.3 3 2 0 3 3 3 0 Coiled-coil region of CCDC155 or KASH SHE3 PF17078.5 EMD61259.1 - 5.6 6.6 61.8 0.57 9.9 8.7 4.3 2 1 1 4 4 4 0 SWI5-dependent HO expression protein 3 RAC_head PF16717.5 EMD61260.1 - 4.4e-30 104.5 8.4 4.4e-30 104.5 8.4 3.4 2 1 0 2 2 2 1 Ribosome-associated complex head domain DnaJ PF00226.31 EMD61260.1 - 2e-20 72.6 0.4 9.5e-20 70.5 0.4 2.3 1 0 0 1 1 1 1 DnaJ domain Trm56 PF01994.16 EMD61260.1 - 0.089 12.7 0.1 0.21 11.5 0.1 1.7 1 0 0 1 1 1 0 tRNA ribose 2'-O-methyltransferase, aTrm56 UPF0565 PF10561.9 EMD61260.1 - 0.24 10.6 3.9 0.36 10.0 3.9 1.4 1 0 0 1 1 1 0 Uncharacterised protein family UPF0565 LMBR1 PF04791.16 EMD61260.1 - 1.7 7.5 8.5 2 7.2 8.5 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Usp PF00582.26 EMD61261.1 - 5e-20 72.5 0.0 1.6e-19 70.8 0.0 1.9 1 0 0 1 1 1 1 Universal stress protein family ABA_GPCR PF12430.8 EMD61262.1 - 1.2e-58 197.8 8.6 2.4e-58 196.8 1.3 2.3 2 0 0 2 2 2 2 Abscisic acid G-protein coupled receptor GPHR_N PF12537.8 EMD61262.1 - 7.6e-23 80.4 2.1 1.6e-22 79.3 0.0 2.6 3 0 0 3 3 3 1 The Golgi pH Regulator (GPHR) Family N-terminal DprA_WH PF17782.1 EMD61262.1 - 0.096 12.8 0.0 0.43 10.7 0.0 2.1 2 0 0 2 2 2 0 DprA winged helix domain DUF3169 PF11368.8 EMD61262.1 - 0.1 12.1 0.1 0.3 10.6 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3169) FANCL_C PF11793.8 EMD61264.1 - 5.7e-06 26.4 3.6 1.3e-05 25.3 3.6 1.6 1 0 0 1 1 1 1 FANCL C-terminal domain RINGv PF12906.7 EMD61264.1 - 7.1e-06 26.1 7.4 7.1e-06 26.1 7.4 1.7 2 0 0 2 2 2 1 RING-variant domain zf-RING_2 PF13639.6 EMD61264.1 - 0.13 12.6 8.4 0.29 11.5 8.4 1.6 1 1 0 1 1 1 0 Ring finger domain KIAA1328 PF15369.6 EMD61264.1 - 2.5 7.9 4.1 0.68 9.7 1.3 1.4 2 0 0 2 2 2 0 Uncharacterised protein KIAA1328 TANGO2 PF05742.12 EMD61266.1 - 2.3e-76 257.2 0.0 2.7e-76 257.0 0.0 1.0 1 0 0 1 1 1 1 Transport and Golgi organisation 2 Cytochrom_C550 PF14495.6 EMD61269.1 - 0.0021 17.8 1.1 0.0023 17.6 1.1 1.2 1 0 0 1 1 1 1 Cytochrome c-550 domain Siah-Interact_N PF09032.11 EMD61269.1 - 0.0029 17.9 6.7 0.0043 17.3 6.7 1.4 1 1 0 1 1 1 1 Siah interacting protein, N terminal DDE_Tnp_1_2 PF13586.6 EMD61269.1 - 0.098 13.0 2.9 0.13 12.6 2.9 1.1 1 0 0 1 1 1 0 Transposase DDE domain Cytochrome_C554 PF13435.6 EMD61269.1 - 0.1 13.5 4.6 0.15 12.9 4.6 1.4 1 1 0 1 1 1 0 Cytochrome c554 and c-prime Mur_ligase_M PF08245.12 EMD61269.1 - 0.12 12.4 0.1 0.12 12.3 0.1 1.1 1 0 0 1 1 1 0 Mur ligase middle domain MAGE_N PF12440.8 EMD61269.1 - 1.7 9.4 13.2 2.9 8.6 13.2 1.5 1 1 0 1 1 1 0 Melanoma associated antigen family N terminal Aminotran_5 PF00266.19 EMD61271.1 - 6.6e-12 45.1 0.0 9.2e-12 44.6 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 EMD61271.1 - 2.1e-05 23.9 0.0 3e-05 23.4 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 EMD61271.1 - 0.022 14.1 0.1 0.056 12.7 0.0 1.6 2 0 0 2 2 2 0 DegT/DnrJ/EryC1/StrS aminotransferase family FeS_assembly_P PF01883.19 EMD61271.1 - 0.037 14.2 0.1 0.21 11.8 0.0 2.2 2 0 0 2 2 2 0 Iron-sulfur cluster assembly protein SepSecS PF05889.13 EMD61271.1 - 0.08 11.6 0.0 0.11 11.2 0.0 1.2 1 0 0 1 1 1 0 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS Ank_2 PF12796.7 EMD61272.1 - 2.4e-28 98.5 8.1 3.6e-10 40.3 1.4 3.4 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMD61272.1 - 6.2e-18 64.9 2.2 1.4e-05 25.6 0.0 6.1 1 1 6 7 7 7 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EMD61272.1 - 2.7e-14 53.0 3.4 3.9e-05 23.9 0.4 5.5 2 1 4 6 6 6 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMD61272.1 - 3.5e-13 48.4 0.8 0.0056 17.1 0.0 5.3 5 0 0 5 5 5 4 Ankyrin repeat Ank PF00023.30 EMD61272.1 - 1.3e-11 44.3 3.7 0.0051 17.2 0.1 5.8 6 0 0 6 6 6 3 Ankyrin repeat Sugar_tr PF00083.24 EMD61273.1 - 7.2e-84 282.2 25.7 8.5e-84 282.0 25.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD61273.1 - 4e-15 55.6 35.5 4e-15 55.6 35.5 2.7 1 1 2 3 3 3 2 Major Facilitator Superfamily Fungal_trans PF04082.18 EMD61274.1 - 9.2e-09 34.7 0.1 1.7e-08 33.9 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Glyco_hydro_31 PF01055.26 EMD61275.1 - 5.3e-113 378.5 4.6 7.6e-113 378.0 4.6 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 EMD61275.1 - 8.2e-06 26.1 1.6 0.00013 22.2 0.1 3.1 2 1 0 2 2 2 1 Galactose mutarotase-like DUF4968 PF16338.5 EMD61275.1 - 0.0049 17.1 0.0 0.0081 16.5 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4968) Glyco_hydro_39 PF01229.17 EMD61276.1 - 0.0043 15.7 0.1 0.0063 15.2 0.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 39 AdoMet_dc PF02675.15 EMD61277.1 - 0.17 12.1 0.6 0.66 10.3 0.1 2.1 2 1 1 3 3 3 0 S-adenosylmethionine decarboxylase DUF2375 PF09558.10 EMD61279.1 - 0.13 12.3 0.2 0.26 11.3 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2375) Vif PF00559.17 EMD61279.1 - 0.15 11.7 0.0 0.16 11.6 0.0 1.3 1 0 0 1 1 1 0 Retroviral Vif (Viral infectivity) protein bZIP_1 PF00170.21 EMD61281.1 - 5.5e-05 23.2 10.3 5.5e-05 23.2 10.3 2.1 2 0 0 2 2 2 1 bZIP transcription factor GCN5L1 PF06320.13 EMD61281.1 - 0.039 14.1 5.5 0.07 13.3 5.5 1.3 1 0 0 1 1 1 0 GCN5-like protein 1 (GCN5L1) bZIP_Maf PF03131.17 EMD61281.1 - 0.52 10.9 8.8 1.3 9.6 8.8 1.6 1 0 0 1 1 1 0 bZIP Maf transcription factor HET PF06985.11 EMD61282.1 - 3.2e-15 56.7 0.8 3.4e-15 56.6 0.8 1.0 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Tannase PF07519.11 EMD61284.1 - 1.1e-105 354.3 1.0 2.3e-105 353.2 1.0 1.5 1 1 0 1 1 1 1 Tannase and feruloyl esterase Hydrolase_4 PF12146.8 EMD61284.1 - 0.014 14.7 0.0 0.044 13.1 0.0 1.8 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EMD61284.1 - 0.03 13.9 0.1 1.4 8.5 0.1 2.3 2 0 0 2 2 2 0 alpha/beta hydrolase fold adh_short PF00106.25 EMD61285.1 - 7e-30 104.0 0.0 1.2e-29 103.2 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD61285.1 - 9.4e-24 84.3 0.0 1.3e-23 83.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD61285.1 - 1.3e-09 38.3 0.0 1.8e-09 37.7 0.0 1.2 1 0 0 1 1 1 1 KR domain adh_short PF00106.25 EMD61286.1 - 1.5e-08 34.3 0.1 1.9e-08 34.0 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD61286.1 - 5.8e-07 29.3 0.1 7.1e-07 29.0 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NADHdh PF00146.21 EMD61286.1 - 0.08 12.2 0.2 0.1 11.9 0.2 1.2 1 0 0 1 1 1 0 NADH dehydrogenase TcdA_TcdB_pore PF12920.7 EMD61286.1 - 0.13 10.5 0.1 0.15 10.3 0.1 1.0 1 0 0 1 1 1 0 TcdA/TcdB pore forming domain WD40 PF00400.32 EMD61288.1 - 1.1e-94 307.8 49.1 6.2e-10 39.5 1.2 10.3 10 0 0 10 10 9 9 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD61288.1 - 1.2e-29 102.5 11.4 1.8e-05 24.9 0.0 8.6 1 1 7 8 8 8 8 Anaphase-promoting complex subunit 4 WD40 domain NACHT PF05729.12 EMD61288.1 - 1.9e-25 89.7 0.1 3.4e-25 88.9 0.1 1.4 1 0 0 1 1 1 1 NACHT domain Ge1_WD40 PF16529.5 EMD61288.1 - 4.4e-16 58.8 22.1 8.3e-07 28.3 0.9 6.7 1 1 5 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 EMD61288.1 - 5.6e-15 55.0 24.5 0.07 11.8 0.1 8.9 1 1 8 9 9 9 6 Nucleoporin Nup120/160 HET PF06985.11 EMD61288.1 - 3.4e-12 46.9 10.1 3.3e-10 40.5 1.0 3.6 2 1 1 3 3 3 2 Heterokaryon incompatibility protein (HET) Nucleoporin_N PF08801.11 EMD61288.1 - 9.4e-08 31.2 18.0 0.00048 19.0 0.3 5.3 1 1 3 5 5 5 4 Nup133 N terminal like WD40_like PF17005.5 EMD61288.1 - 4.4e-05 23.0 0.1 0.62 9.3 0.1 3.6 4 0 0 4 4 4 2 WD40-like domain CDtoxinA PF03498.14 EMD61288.1 - 8.2e-05 22.2 0.1 16 5.1 0.0 4.9 2 1 1 4 4 4 0 Cytolethal distending toxin A/C domain AAA_16 PF13191.6 EMD61288.1 - 0.002 18.5 0.0 0.0084 16.5 0.0 2.1 1 0 0 1 1 1 1 AAA ATPase domain Nbas_N PF15492.6 EMD61288.1 - 0.0035 16.7 13.7 3.7 6.8 0.1 6.6 2 2 6 8 8 8 1 Neuroblastoma-amplified sequence, N terminal Gmad1 PF10647.9 EMD61288.1 - 0.0045 16.8 13.3 2.4 7.8 1.4 4.6 2 1 2 4 4 4 2 Lipoprotein LpqB beta-propeller domain AAA_19 PF13245.6 EMD61288.1 - 0.025 14.9 0.0 0.048 14.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EMD61288.1 - 0.046 14.0 0.0 0.17 12.1 0.0 2.0 1 1 1 2 2 2 0 AAA domain AAA PF00004.29 EMD61288.1 - 0.053 14.0 0.0 0.22 11.9 0.0 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Cytochrom_D1 PF02239.16 EMD61288.1 - 0.13 10.7 1.3 2.8 6.4 0.1 3.0 1 1 1 3 3 3 0 Cytochrome D1 heme domain AAA_11 PF13086.6 EMD61288.1 - 0.14 11.9 0.0 0.23 11.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain NYD-SP28_assoc PF14775.6 EMD61288.1 - 0.19 11.8 4.0 38 4.5 0.1 5.4 6 0 0 6 6 5 0 Sperm tail C-terminal domain Peptidase_M28 PF04389.17 EMD61289.1 - 6.9e-39 133.6 0.2 9.2e-39 133.2 0.2 1.2 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 EMD61289.1 - 9.9e-08 31.9 0.0 2.2e-07 30.8 0.0 1.5 1 0 0 1 1 1 1 PA domain Peptidase_M20 PF01546.28 EMD61289.1 - 3e-06 27.1 0.0 5e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 DUF3605 PF12239.8 EMD61290.1 - 1.8e-52 177.7 0.6 2.1e-52 177.5 0.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3605) CPL PF08144.11 EMD61291.1 - 5.3e-20 72.2 0.9 6.7e-19 68.6 0.0 3.0 4 0 0 4 4 4 1 CPL (NUC119) domain DUF5588 PF17826.1 EMD61291.1 - 0.12 11.2 1.1 0.25 10.2 1.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5588) DNA_RNApol_7kD PF03604.13 EMD61292.1 - 1.9e-17 62.6 5.7 2.4e-17 62.3 5.7 1.1 1 0 0 1 1 1 1 DNA directed RNA polymerase, 7 kDa subunit MCM_OB PF17207.3 EMD61292.1 - 0.0072 16.2 0.4 0.0078 16.1 0.4 1.0 1 0 0 1 1 1 1 MCM OB domain HypA PF01155.19 EMD61292.1 - 0.0081 16.2 0.3 0.0084 16.1 0.3 1.1 1 0 0 1 1 1 1 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-CRD PF17979.1 EMD61292.1 - 0.021 15.0 0.4 0.021 14.9 0.4 1.1 1 0 0 1 1 1 0 Cysteine rich domain with multizinc binding regions DZR PF12773.7 EMD61292.1 - 0.029 14.4 0.8 0.046 13.7 0.8 1.5 1 1 0 1 1 1 0 Double zinc ribbon Zn_Tnp_IS1595 PF12760.7 EMD61292.1 - 0.067 13.2 1.6 0.71 9.9 0.5 2.1 2 0 0 2 2 2 0 Transposase zinc-ribbon domain zinc_ribbon_13 PF09855.9 EMD61292.1 - 0.076 13.2 0.4 0.11 12.6 0.4 1.7 1 1 0 1 1 1 0 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) LRV_FeS PF05484.11 EMD61292.1 - 0.087 12.8 0.2 0.087 12.8 0.2 1.8 1 1 1 2 2 2 0 LRV protein FeS4 cluster TFIIS_C PF01096.18 EMD61292.1 - 0.12 12.3 3.9 4.4 7.2 0.2 2.4 2 1 0 2 2 2 0 Transcription factor S-II (TFIIS) DUF951 PF06107.11 EMD61292.1 - 0.14 12.1 2.0 0.79 9.7 0.3 2.0 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF951) DUF35_N PF12172.8 EMD61292.1 - 0.3 11.0 0.3 0.3 11.0 0.3 2.1 2 0 0 2 2 2 0 Rubredoxin-like zinc ribbon domain (DUF35_N) Zn-ribbon_8 PF09723.10 EMD61292.1 - 0.85 9.8 5.2 4.7 7.4 5.1 2.0 1 1 0 1 1 1 0 Zinc ribbon domain zinc_ribbon_4 PF13717.6 EMD61292.1 - 0.92 9.5 4.7 0.38 10.7 0.6 2.0 1 1 1 2 2 2 0 zinc-ribbon domain Pkinase PF00069.25 EMD61293.1 - 5e-60 203.1 0.0 6.4e-59 199.5 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD61293.1 - 2.1e-26 92.7 0.3 4.2e-21 75.4 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Haspin_kinase PF12330.8 EMD61293.1 - 2.7e-05 23.3 0.0 4.3e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EMD61293.1 - 0.00038 20.5 0.1 0.034 14.1 0.2 2.5 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 EMD61293.1 - 0.0005 19.5 0.0 0.0014 18.0 0.0 1.7 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EMD61293.1 - 0.01 15.2 0.4 0.021 14.1 0.0 1.7 2 0 0 2 2 2 0 Kinase-like RIO1 PF01163.22 EMD61293.1 - 0.085 12.4 0.0 0.21 11.2 0.0 1.6 1 0 0 1 1 1 0 RIO1 family Filament PF00038.21 EMD61295.1 - 0.0014 18.3 34.7 0.0014 18.3 34.7 4.4 3 1 0 3 3 3 2 Intermediate filament protein DUF2935 PF11155.8 EMD61295.1 - 0.018 15.4 1.0 18 5.7 0.1 4.9 3 2 0 3 3 3 0 Domain of unknown function (DUF2935) Mod_r PF07200.13 EMD61297.1 - 1.2e-33 116.2 0.1 1.6e-33 115.9 0.1 1.1 1 0 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein DUF3263 PF11662.8 EMD61297.1 - 0.015 15.1 0.2 0.015 15.1 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3263) AIP3 PF03915.13 EMD61297.1 - 0.065 12.3 0.4 0.089 11.9 0.4 1.1 1 0 0 1 1 1 0 Actin interacting protein 3 WD40 PF00400.32 EMD61298.1 - 1.6e-23 82.5 14.1 2.2e-05 25.1 0.2 7.0 6 2 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD61298.1 - 4.7e-11 42.8 9.9 2.8e-06 27.5 0.4 4.1 2 2 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain TFIIIC_delta PF12657.7 EMD61298.1 - 0.00059 19.8 11.6 19 5.1 11.1 3.5 1 1 1 2 2 2 1 Transcription factor IIIC subunit delta N-term Kelch_6 PF13964.6 EMD61298.1 - 0.011 16.1 3.3 0.24 11.7 0.1 3.0 3 0 0 3 3 3 0 Kelch motif Kelch_3 PF13415.6 EMD61298.1 - 0.039 14.3 1.5 0.14 12.4 0.1 2.7 2 1 1 3 3 3 0 Galactose oxidase, central domain IKI3 PF04762.12 EMD61298.1 - 1.7 6.5 6.4 0.92 7.4 0.3 2.0 2 0 0 2 2 2 0 IKI3 family CBP PF12192.8 EMD61299.1 - 4.2e-06 26.9 3.2 8.4e-06 25.9 3.2 1.6 1 0 0 1 1 1 1 Fungal calcium binding protein GIY-YIG PF01541.24 EMD61300.1 - 0.042 14.1 0.2 0.1 12.9 0.2 1.6 1 0 0 1 1 1 0 GIY-YIG catalytic domain CBM_19 PF03427.13 EMD61301.1 - 1.8e-06 27.8 5.3 1.8e-06 27.8 5.3 2.8 1 1 1 2 2 2 1 Carbohydrate binding domain (family 19) Glyco_hydro_61 PF03443.14 EMD61301.1 - 0.014 15.4 0.0 0.026 14.5 0.0 1.5 1 1 0 1 1 1 0 Glycosyl hydrolase family 61 SNF5 PF04855.12 EMD61302.1 - 2.7e-87 292.5 0.0 3.4e-87 292.2 0.0 1.1 1 0 0 1 1 1 1 SNF5 / SMARCB1 / INI1 GATA PF00320.27 EMD61302.1 - 4.7e-05 22.9 2.8 0.0001 21.8 2.8 1.6 1 0 0 1 1 1 1 GATA zinc finger Rubredoxin_2 PF18073.1 EMD61302.1 - 1.1 9.0 8.9 11 5.9 3.9 2.6 2 0 0 2 2 2 0 Rubredoxin metal binding domain TFIIA PF03153.13 EMD61303.1 - 0.13 12.2 4.7 0.13 12.2 4.7 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Ribosomal_60s PF00428.19 EMD61303.1 - 4 8.1 11.0 12 6.6 11.0 1.8 1 0 0 1 1 1 0 60s Acidic ribosomal protein SpoIIIAH PF12685.7 EMD61304.1 - 6.7 6.5 24.6 5.9e+02 0.1 24.4 2.4 1 1 0 1 1 1 0 SpoIIIAH-like protein SURF4 PF02077.15 EMD61305.1 - 3.7e-95 318.5 5.5 4.3e-95 318.3 5.5 1.0 1 0 0 1 1 1 1 SURF4 family UPF0139 PF03669.13 EMD61305.1 - 1.9 8.4 5.2 0.39 10.6 0.5 2.3 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0139) Halogen_Hydrol PF10112.9 EMD61305.1 - 2.2 8.2 3.8 16 5.4 1.8 2.5 2 0 0 2 2 2 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein DUF2632 PF10943.8 EMD61305.1 - 2.6 7.6 10.6 0.87 9.1 2.3 2.4 2 1 1 3 3 3 0 Protein of unknown function (DUF2632) SecD_SecF PF02355.16 EMD61305.1 - 8.3 5.7 9.8 0.19 11.1 2.6 1.8 2 1 0 2 2 2 0 Protein export membrane protein IU_nuc_hydro PF01156.19 EMD61306.1 - 1.7e-54 185.5 0.0 2.4e-53 181.7 0.0 2.4 1 1 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase Zn_clus PF00172.18 EMD61307.1 - 8.1e-08 32.3 10.1 1.3e-07 31.6 10.1 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Nop PF01798.18 EMD61309.1 - 3.9e-64 216.3 0.0 5.4e-64 215.8 0.0 1.2 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin Prp31_C PF09785.9 EMD61309.1 - 3.4e-45 153.8 2.4 3.4e-45 153.8 2.4 1.7 2 0 0 2 2 2 1 Prp31 C terminal domain HAT PF02184.16 EMD61310.1 - 3.9e-28 97.1 71.5 4.3e-14 52.2 2.4 15.0 15 1 0 15 15 15 8 HAT (Half-A-TPR) repeat TPR_14 PF13428.6 EMD61310.1 - 1e-23 81.9 23.6 0.0076 17.0 0.7 11.3 7 3 6 13 13 13 8 Tetratricopeptide repeat TPR_19 PF14559.6 EMD61310.1 - 3.6e-18 65.8 2.3 0.00011 22.6 0.0 8.2 6 2 3 9 9 9 5 Tetratricopeptide repeat Suf PF05843.14 EMD61310.1 - 1.7e-17 64.3 20.2 0.00059 19.9 0.3 7.0 4 3 2 6 6 6 5 Suppressor of forked protein (Suf) TPR_17 PF13431.6 EMD61310.1 - 3.2e-11 42.8 4.0 0.3 11.5 0.0 6.6 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_15 PF13429.6 EMD61310.1 - 3.6e-07 29.7 13.6 1.3 8.2 0.1 6.2 2 1 3 6 6 6 4 Tetratricopeptide repeat TPR_8 PF13181.6 EMD61310.1 - 3.9e-07 29.8 2.2 14 6.2 0.0 7.9 8 0 0 8 8 8 0 Tetratricopeptide repeat TPR_12 PF13424.6 EMD61310.1 - 0.00015 22.0 15.5 7.4 6.9 0.0 8.5 10 1 2 12 12 11 1 Tetratricopeptide repeat TPR_16 PF13432.6 EMD61310.1 - 0.0053 17.4 10.3 0.059 14.0 0.0 6.2 8 1 1 9 9 7 2 Tetratricopeptide repeat U3_assoc_6 PF08640.11 EMD61310.1 - 0.016 15.3 21.3 0.082 13.0 1.6 6.7 5 2 2 7 7 7 0 U3 small nucleolar RNA-associated protein 6 TPR_2 PF07719.17 EMD61310.1 - 0.081 13.1 19.6 2.9 8.2 0.0 9.5 13 0 0 13 13 12 0 Tetratricopeptide repeat QIL1 PF15884.5 EMD61310.1 - 0.09 13.4 0.0 2 9.1 0.0 3.1 2 0 0 2 2 2 0 MICOS complex subunit MIC13, QIL1 TPR_6 PF13174.6 EMD61310.1 - 0.14 12.8 22.9 21 6.0 0.2 9.4 11 1 0 11 11 10 0 Tetratricopeptide repeat adh_short_C2 PF13561.6 EMD61311.1 - 2e-57 194.5 0.8 2.5e-57 194.1 0.8 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EMD61311.1 - 4.5e-45 153.5 0.3 5.5e-45 153.2 0.3 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EMD61311.1 - 7.9e-10 38.9 0.5 2e-09 37.6 0.5 1.7 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 EMD61311.1 - 0.00013 21.5 0.1 0.00017 21.2 0.1 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 14-3-3 PF00244.20 EMD61314.1 - 1.7e-07 31.0 0.0 3.5e-07 29.9 0.0 1.5 2 0 0 2 2 2 1 14-3-3 protein TNFR_c6 PF00020.18 EMD61316.1 - 0.76 10.2 7.2 0.22 12.0 2.2 2.4 2 1 0 2 2 2 0 TNFR/NGFR cysteine-rich region MFS_1 PF07690.16 EMD61317.1 - 1.5e-39 136.0 49.8 1.5e-39 136.0 49.8 2.3 2 1 0 2 2 2 1 Major Facilitator Superfamily OATP PF03137.20 EMD61317.1 - 2.5 6.3 20.2 27 2.9 18.5 2.8 1 1 1 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family SET PF00856.28 EMD61318.1 - 2.2e-09 37.9 0.0 9.5e-09 35.9 0.0 2.1 1 1 0 1 1 1 1 SET domain KH_8 PF17903.1 EMD61319.1 - 1.9e-29 101.6 0.0 4.1e-29 100.5 0.0 1.6 1 0 0 1 1 1 1 Krr1 KH1 domain KH_1 PF00013.29 EMD61319.1 - 0.033 14.0 0.0 0.19 11.5 0.0 2.4 1 1 1 2 2 2 0 KH domain Herpes_DNAp_acc PF04929.12 EMD61319.1 - 5.1 6.0 9.2 6.7 5.6 9.2 1.1 1 0 0 1 1 1 0 Herpes DNA replication accessory factor CN_hydrolase PF00795.22 EMD61320.1 - 7.8e-43 146.7 0.0 9.1e-43 146.5 0.0 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase tRNA_int_end_N2 PF12928.7 EMD61321.1 - 7.6e-25 86.9 0.1 1.4e-24 86.1 0.1 1.4 1 0 0 1 1 1 1 tRNA-splicing endonuclease subunit sen54 N-term tRNA_int_endo_N PF02778.14 EMD61321.1 - 0.065 12.9 0.1 0.25 11.0 0.0 1.9 2 0 0 2 2 2 0 tRNA intron endonuclease, N-terminal domain GCV_T PF01571.21 EMD61322.1 - 5.9e-86 288.0 0.0 7.7e-86 287.6 0.0 1.2 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.11 EMD61322.1 - 6.1e-23 80.5 0.2 1.1e-22 79.7 0.2 1.4 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain DUF3659 PF12396.8 EMD61322.1 - 0.1 12.5 0.2 0.43 10.5 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3659) V-ATPase_C PF03223.15 EMD61323.1 - 2.6e-129 431.8 0.2 2.9e-129 431.7 0.2 1.0 1 0 0 1 1 1 1 V-ATPase subunit C mRNA_cap_C PF03919.15 EMD61323.1 - 0.023 15.3 0.1 0.059 14.0 0.1 1.7 1 0 0 1 1 1 0 mRNA capping enzyme, C-terminal domain HET PF06985.11 EMD61324.1 - 4.2e-28 98.5 0.0 5.7e-28 98.1 0.0 1.2 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) TPR_12 PF13424.6 EMD61326.1 - 2e-15 56.8 0.0 1.8e-09 37.7 0.0 1.6 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 EMD61326.1 - 1.2e-09 37.8 0.0 0.0014 18.5 0.0 2.1 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 EMD61326.1 - 7.2e-08 32.8 0.1 0.01 16.3 0.1 2.2 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 EMD61326.1 - 3.9e-07 30.3 0.0 0.026 15.3 0.0 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 EMD61326.1 - 5.7e-07 29.3 0.0 0.03 14.5 0.0 2.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 EMD61326.1 - 5.9e-05 22.9 0.0 0.52 10.6 0.0 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 EMD61326.1 - 0.00018 21.2 0.0 0.75 9.7 0.0 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat Vps39_1 PF10366.9 EMD61326.1 - 0.00076 19.7 0.0 0.2 12.0 0.0 2.0 1 1 1 2 2 2 1 Vacuolar sorting protein 39 domain 1 PPR PF01535.20 EMD61326.1 - 0.00086 19.4 0.0 0.36 11.2 0.0 2.2 2 0 0 2 2 2 1 PPR repeat TPR_7 PF13176.6 EMD61326.1 - 0.00092 19.1 0.0 0.93 9.7 0.0 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EMD61326.1 - 0.00096 19.3 0.0 0.0022 18.2 0.0 1.7 1 1 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_20 PF14561.6 EMD61326.1 - 0.0024 18.2 0.1 1.5 9.2 0.0 2.1 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_4 PF07721.14 EMD61326.1 - 0.0091 16.5 0.1 0.88 10.4 0.0 2.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 EMD61326.1 - 0.011 16.3 0.0 0.24 12.1 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 EMD61326.1 - 0.014 16.0 0.0 1 10.1 0.0 2.5 3 0 0 3 3 2 0 Tetratricopeptide repeat ATP13 PF12921.7 EMD61326.1 - 0.037 13.9 0.0 4 7.3 0.0 2.1 1 1 0 2 2 2 0 Mitochondrial ATPase expression TPR_MalT PF17874.1 EMD61326.1 - 0.049 13.0 0.0 0.049 13.0 0.0 1.0 1 0 0 1 1 1 0 MalT-like TPR region MORN_2 PF07661.13 EMD61326.1 - 0.056 13.7 0.0 0.34 11.3 0.0 2.1 2 0 0 2 2 2 0 MORN repeat variant Clathrin PF00637.20 EMD61326.1 - 0.071 13.0 0.2 1.3 8.8 0.1 2.0 1 1 1 2 2 2 0 Region in Clathrin and VPS MFS_1 PF07690.16 EMD61328.1 - 8.7e-36 123.6 36.4 8.7e-36 123.6 36.4 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Pkinase PF00069.25 EMD61329.1 - 2e-69 233.9 0.0 3.6e-69 233.1 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD61329.1 - 1.3e-37 129.5 0.0 2.5e-37 128.6 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMD61329.1 - 5.5e-06 25.9 0.0 1.2e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EMD61329.1 - 0.00021 20.2 0.0 0.00082 18.3 0.0 1.9 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 EMD61329.1 - 0.00045 20.2 0.0 0.0012 18.9 0.0 1.7 1 0 0 1 1 1 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 EMD61329.1 - 0.002 17.2 0.0 0.0037 16.4 0.0 1.3 1 0 0 1 1 1 1 Seadornavirus VP7 Kdo PF06293.14 EMD61329.1 - 0.032 13.6 0.2 0.1 11.9 0.0 1.9 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family FtsX_ECD PF18075.1 EMD61329.1 - 0.052 14.2 0.2 0.25 12.0 0.0 2.4 2 0 0 2 2 2 0 FtsX extracellular domain Mito_carr PF00153.27 EMD61330.1 - 8.4e-68 224.4 1.0 8.5e-24 83.3 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 EMD61330.1 - 0.1 11.8 0.2 13 4.8 0.0 3.3 4 0 0 4 4 4 0 Gammaproteobacterial serine protease Dna2 PF08696.11 EMD61331.1 - 4.4e-72 242.2 0.1 7.6e-72 241.4 0.1 1.4 1 0 0 1 1 1 1 DNA replication factor Dna2 Cas_Cas4 PF01930.17 EMD61331.1 - 2.6e-07 30.9 0.0 1.5e-06 28.4 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function DUF83 Csa1 PF06023.12 EMD61331.1 - 0.017 14.5 0.8 0.044 13.1 0.0 2.0 2 1 0 2 2 2 0 CRISPR-associated exonuclease Csa1 AAA_12 PF13087.6 EMD61332.1 - 3.8e-40 137.6 0.0 4.9e-40 137.3 0.0 1.1 1 0 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.6 EMD61332.1 - 0.0069 16.2 0.0 0.016 15.0 0.0 1.6 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain Viral_helicase1 PF01443.18 EMD61332.1 - 0.018 14.8 0.0 0.028 14.2 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Amino_oxidase PF01593.24 EMD61333.1 - 1.8e-10 40.7 0.0 4.5e-10 39.4 0.0 1.6 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EMD61333.1 - 3.8e-10 39.8 0.0 7.1e-10 39.0 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EMD61333.1 - 4.3e-09 35.9 1.0 6.6e-09 35.3 1.0 1.2 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 EMD61333.1 - 2.3e-06 26.6 0.5 3.5e-06 26.0 0.5 1.2 1 0 0 1 1 1 1 HI0933-like protein DAO PF01266.24 EMD61333.1 - 5.5e-06 26.2 1.5 1.8e-05 24.5 1.2 1.9 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_oxidored PF12831.7 EMD61333.1 - 1.2e-05 24.9 0.4 1.8e-05 24.3 0.4 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 EMD61333.1 - 1.8e-05 24.1 0.2 2.7e-05 23.6 0.2 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EMD61333.1 - 4.6e-05 22.8 0.1 0.0001 21.7 0.1 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EMD61333.1 - 0.0002 21.9 0.1 0.00051 20.5 0.1 1.7 2 0 0 2 2 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EMD61333.1 - 0.00072 18.7 0.2 0.0011 18.1 0.2 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A Thi4 PF01946.17 EMD61333.1 - 0.0011 18.2 0.1 0.0023 17.2 0.1 1.5 2 0 0 2 2 2 1 Thi4 family Pyr_redox_3 PF13738.6 EMD61333.1 - 0.0015 17.8 0.0 0.0038 16.5 0.0 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EMD61333.1 - 0.0048 16.0 0.1 0.0096 15.0 0.0 1.5 2 0 0 2 2 2 1 Lycopene cyclase protein ApbA PF02558.16 EMD61333.1 - 0.032 13.9 0.2 0.056 13.1 0.2 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA TrkA_N PF02254.18 EMD61333.1 - 0.16 12.2 0.2 0.37 11.1 0.2 1.6 1 0 0 1 1 1 0 TrkA-N domain WD40 PF00400.32 EMD61334.1 - 1.1e-05 26.1 6.2 7.3 7.6 0.2 6.0 6 0 0 6 6 6 2 WD domain, G-beta repeat Lactonase PF10282.9 EMD61334.1 - 5.1e-05 22.7 0.1 0.16 11.2 0.0 2.8 3 0 0 3 3 3 2 Lactonase, 7-bladed beta-propeller ANAPC4_WD40 PF12894.7 EMD61334.1 - 0.036 14.3 0.0 0.62 10.4 0.0 2.8 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Mito_carr PF00153.27 EMD61335.1 - 6.4e-48 160.6 6.2 1.1e-18 66.9 0.2 4.1 3 1 1 4 4 4 4 Mitochondrial carrier protein Serine_protease PF18405.1 EMD61335.1 - 0.00035 19.8 0.5 0.015 14.5 0.1 2.2 2 0 0 2 2 2 2 Gammaproteobacterial serine protease DUF3337 PF11816.8 EMD61336.1 - 9.5e-57 191.6 0.0 1.8e-56 190.7 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3337) WD40 PF00400.32 EMD61336.1 - 5.6e-18 65.0 13.8 6.3e-05 23.7 0.1 6.7 6 0 0 6 6 6 4 WD domain, G-beta repeat Acetyltransf_7 PF13508.7 EMD61336.1 - 9.4e-06 26.0 0.0 2.3e-05 24.7 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EMD61336.1 - 2.5e-05 24.5 0.0 6.6e-05 23.1 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EMD61336.1 - 0.0017 18.3 0.0 0.0037 17.2 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EMD61336.1 - 0.0028 17.7 0.0 0.02 15.0 0.0 2.3 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain ANAPC4_WD40 PF12894.7 EMD61336.1 - 0.025 14.9 0.1 0.13 12.6 0.0 2.3 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EMD61336.1 - 0.053 12.2 1.4 0.087 11.5 0.1 1.8 2 0 0 2 2 2 0 Nucleoporin Nup120/160 AA_permease_2 PF13520.6 EMD61337.1 - 2.7e-46 158.3 48.8 3.1e-46 158.1 48.8 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EMD61337.1 - 9e-25 87.2 37.8 1.3e-24 86.7 37.8 1.1 1 0 0 1 1 1 1 Amino acid permease Cu-oxidase_3 PF07732.15 EMD61339.1 - 4.6e-41 139.6 11.3 2.4e-40 137.3 1.6 3.5 3 0 0 3 3 3 2 Multicopper oxidase Cu-oxidase_2 PF07731.14 EMD61339.1 - 6.4e-40 136.1 13.4 8.7e-39 132.4 1.6 3.9 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.22 EMD61339.1 - 2.2e-34 118.9 0.6 4.8e-34 117.8 0.6 1.6 1 0 0 1 1 1 1 Multicopper oxidase DMRT-like PF15791.5 EMD61340.1 - 0.15 12.5 2.0 0.31 11.5 2.0 1.5 1 0 0 1 1 1 0 Doublesex-and mab-3-related transcription factor C1 and C2 Ribonuc_P_40 PF08584.11 EMD61342.1 - 1.5e-73 247.6 0.0 2.3e-73 246.9 0.0 1.3 1 0 0 1 1 1 1 Ribonuclease P 40kDa (Rpp40) subunit SIR2 PF02146.17 EMD61344.1 - 1.9e-54 184.2 0.0 2.9e-54 183.7 0.0 1.3 1 0 0 1 1 1 1 Sir2 family TPP_enzyme_M PF00205.22 EMD61344.1 - 0.0011 18.6 0.3 0.33 10.7 0.1 2.6 2 0 0 2 2 2 2 Thiamine pyrophosphate enzyme, central domain DUF592 PF04574.13 EMD61344.1 - 0.047 13.5 0.1 0.12 12.2 0.1 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF592) Pectate_lyase PF03211.13 EMD61346.1 - 8e-84 280.2 7.3 9.7e-84 280.0 7.3 1.0 1 0 0 1 1 1 1 Pectate lyase ABC2_membrane PF01061.24 EMD61347.1 - 6.7e-76 254.4 58.7 3e-40 137.9 17.2 3.0 4 0 0 4 4 4 2 ABC-2 type transporter ABC_tran PF00005.27 EMD61347.1 - 2.1e-34 119.0 0.0 1.4e-16 61.3 0.0 2.7 3 0 0 3 3 2 2 ABC transporter PDR_CDR PF06422.12 EMD61347.1 - 2.5e-32 110.6 0.5 8.5e-28 96.1 0.1 3.2 2 0 0 2 2 2 2 CDR ABC transporter ABC_trans_N PF14510.6 EMD61347.1 - 1.2e-15 57.9 0.1 3.7e-15 56.3 0.1 1.9 1 0 0 1 1 1 1 ABC-transporter N-terminal RsgA_GTPase PF03193.16 EMD61347.1 - 3.3e-06 27.1 0.1 0.0004 20.3 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase ABC2_membrane_3 PF12698.7 EMD61347.1 - 1.4e-05 24.4 42.3 0.00047 19.4 15.7 3.0 2 1 1 3 3 3 2 ABC-2 family transporter protein AAA_18 PF13238.6 EMD61347.1 - 1.8e-05 25.3 0.0 0.0098 16.4 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_21 PF13304.6 EMD61347.1 - 2e-05 24.6 0.0 0.64 9.8 0.0 3.4 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_33 PF13671.6 EMD61347.1 - 9.8e-05 22.5 0.0 0.0099 16.0 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EMD61347.1 - 0.00027 21.4 0.1 0.058 13.8 0.0 2.7 2 0 0 2 2 2 1 AAA ATPase domain AAA_29 PF13555.6 EMD61347.1 - 0.00043 20.0 0.7 0.042 13.6 0.2 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_25 PF13481.6 EMD61347.1 - 0.00067 19.3 0.2 0.0071 15.9 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.6 EMD61347.1 - 0.00089 19.5 0.3 1 9.6 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_17 PF13207.6 EMD61347.1 - 0.0012 19.2 2.0 1.8 9.0 0.0 3.7 3 0 0 3 3 3 1 AAA domain cobW PF02492.19 EMD61347.1 - 0.0083 15.7 0.4 0.55 9.8 0.0 2.3 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain SMC_N PF02463.19 EMD61347.1 - 0.0095 15.4 0.0 2 7.8 0.0 3.5 3 1 0 3 3 3 1 RecF/RecN/SMC N terminal domain NACHT PF05729.12 EMD61347.1 - 0.024 14.6 1.1 4.1 7.3 0.2 2.6 2 0 0 2 2 2 0 NACHT domain AAA PF00004.29 EMD61347.1 - 0.032 14.7 0.1 5.6 7.4 0.0 2.7 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EMD61347.1 - 0.04 14.2 1.0 2.7 8.3 0.2 2.8 2 0 0 2 2 2 0 AAA domain dNK PF01712.19 EMD61347.1 - 0.066 13.1 0.1 5.3 6.8 0.0 2.4 2 0 0 2 2 2 0 Deoxynucleoside kinase AAA_30 PF13604.6 EMD61347.1 - 0.066 12.9 0.0 1.7 8.4 0.0 2.4 2 0 0 2 2 2 0 AAA domain Zn_clus PF00172.18 EMD61348.1 - 5.4e-08 32.8 11.4 1.4e-07 31.5 11.4 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SRA1 PF07304.11 EMD61348.1 - 0.046 13.5 1.9 0.61 9.9 0.0 2.9 3 0 0 3 3 3 0 Steroid receptor RNA activator (SRA1) Ctr PF04145.15 EMD61349.1 - 0.7 10.5 5.0 2.3 8.9 5.0 2.3 1 1 0 1 1 1 0 Ctr copper transporter family Linocin_M18 PF04454.12 EMD61350.1 - 0.23 10.7 0.0 0.33 10.2 0.0 1.2 1 0 0 1 1 1 0 Encapsulating protein for peroxidase DUF3638 PF12340.8 EMD61351.1 - 6.4e-91 303.7 0.9 1.5e-90 302.5 0.9 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3638) DUF3645 PF12359.8 EMD61351.1 - 1.7e-17 62.5 0.9 4.6e-17 61.1 0.9 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF3645) rve_2 PF13333.6 EMD61351.1 - 0.13 12.5 1.2 11 6.3 0.0 2.9 2 0 0 2 2 2 0 Integrase core domain WH2 PF02205.20 EMD61352.1 - 4.3e-10 39.1 0.6 4.3e-10 39.1 0.6 1.8 2 0 0 2 2 2 1 WH2 motif tRNA_synt_2f PF02092.17 EMD61354.1 - 0.012 14.6 0.1 0.013 14.5 0.1 1.1 1 0 0 1 1 1 0 Glycyl-tRNA synthetase beta subunit Thioesterase PF00975.20 EMD61354.1 - 0.031 14.4 0.2 0.032 14.4 0.2 1.1 1 0 0 1 1 1 0 Thioesterase domain YlqD PF11068.8 EMD61354.1 - 0.038 14.4 0.9 0.048 14.0 0.9 1.1 1 0 0 1 1 1 0 YlqD protein FlbT PF07378.11 EMD61354.1 - 0.094 12.8 0.6 0.13 12.4 0.6 1.2 1 0 0 1 1 1 0 Flagellar protein FlbT DUF4446 PF14584.6 EMD61354.1 - 0.13 12.2 0.9 0.18 11.8 0.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) Peptidase_S49_N PF08496.10 EMD61354.1 - 0.42 10.7 2.2 0.8 9.8 2.2 1.5 1 1 0 1 1 1 0 Peptidase family S49 N-terminal Glyco_hydro_62 PF03664.13 EMD61355.1 - 1.1e-164 546.4 16.4 1.2e-164 546.2 16.4 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 62 Cadherin_3 PF16184.5 EMD61355.1 - 0.084 12.9 0.0 0.3 11.1 0.0 1.8 2 0 0 2 2 2 0 Cadherin-like PepSY_2 PF13670.6 EMD61355.1 - 0.13 12.3 0.1 0.37 10.8 0.1 1.8 2 0 0 2 2 2 0 Peptidase propeptide and YPEB domain Haem_oxygenas_2 PF14518.6 EMD61356.1 - 2.6e-43 147.9 0.7 2.6e-43 147.9 0.7 1.8 2 0 0 2 2 2 1 Iron-containing redox enzyme DUF3050 PF11251.8 EMD61356.1 - 0.26 10.9 1.1 2 8.0 0.1 2.5 2 1 0 3 3 3 0 Protein of unknown function (DUF3050) MTS PF05175.14 EMD61357.1 - 1.9e-12 47.1 0.0 5.7e-12 45.5 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_31 PF13847.6 EMD61357.1 - 6.4e-10 39.0 0.0 1.2e-09 38.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMD61357.1 - 1.2e-08 35.5 0.0 3.6e-08 34.0 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.18 EMD61357.1 - 1.1e-05 25.3 0.0 2.5e-05 24.0 0.0 1.6 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 PrmA PF06325.13 EMD61357.1 - 1.1e-05 25.0 0.0 1.9e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) N6_Mtase PF02384.16 EMD61357.1 - 0.00016 21.0 0.0 0.00025 20.4 0.0 1.2 1 0 0 1 1 1 1 N-6 DNA Methylase Methyltransf_11 PF08241.12 EMD61357.1 - 0.00047 20.8 0.0 0.0014 19.2 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_15 PF09445.10 EMD61357.1 - 0.00072 19.2 0.0 0.0015 18.2 0.0 1.4 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_4 PF02390.17 EMD61357.1 - 0.0015 18.0 0.1 0.02 14.4 0.0 2.4 2 0 0 2 2 2 1 Putative methyltransferase Ubie_methyltran PF01209.18 EMD61357.1 - 0.002 17.5 0.0 0.0049 16.2 0.0 1.6 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 EMD61357.1 - 0.011 16.4 0.0 0.028 15.2 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.6 EMD61357.1 - 0.026 14.4 0.0 0.26 11.1 0.0 2.2 1 1 1 2 2 2 0 Methyltransferase domain Cons_hypoth95 PF03602.15 EMD61357.1 - 0.043 13.4 0.0 0.12 12.0 0.0 1.7 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Methyltransf_2 PF00891.18 EMD61357.1 - 0.048 12.9 0.0 0.08 12.2 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase domain Met_10 PF02475.16 EMD61357.1 - 0.076 12.8 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 Met-10+ like-protein Phosphoesterase PF04185.14 EMD61358.1 - 1.7e-37 129.5 1.3 7.7e-37 127.3 1.1 2.0 1 1 1 2 2 2 1 Phosphoesterase family Sulfatase PF00884.23 EMD61358.1 - 0.0027 17.2 0.3 0.0056 16.1 0.2 1.5 1 1 0 1 1 1 1 Sulfatase Cu-oxidase_3 PF07732.15 EMD61359.1 - 1.7e-44 150.6 0.8 1.7e-44 150.6 0.8 2.3 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 EMD61359.1 - 1.9e-37 128.1 7.7 1.9e-33 115.1 0.3 3.5 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.22 EMD61359.1 - 4.1e-32 111.5 0.0 3.4e-31 108.5 0.0 2.2 2 0 0 2 2 2 1 Multicopper oxidase YL1 PF05764.13 EMD61360.1 - 0.0068 16.6 2.1 0.0068 16.6 2.1 1.8 2 0 0 2 2 2 1 YL1 nuclear protein MPM1 PF17234.2 EMD61360.1 - 0.087 13.1 2.0 0.14 12.4 2.0 1.2 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 Methyltransf_31 PF13847.6 EMD61361.1 - 0.0002 21.2 0.0 0.00069 19.4 0.0 1.8 2 1 1 3 3 3 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMD61361.1 - 0.00053 20.6 0.0 0.00097 19.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EMD61361.1 - 0.0012 18.2 0.0 0.0087 15.4 0.0 1.9 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 EMD61361.1 - 0.0014 19.3 0.0 0.0029 18.3 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 EMD61361.1 - 0.0087 16.1 0.0 0.013 15.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMD61361.1 - 0.048 14.3 0.0 0.097 13.3 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.14 EMD61361.1 - 0.12 11.9 0.0 0.2 11.2 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain GST_N_3 PF13417.6 EMD61362.1 - 2e-06 28.1 0.1 6.5e-06 26.5 0.1 1.8 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EMD61362.1 - 4.8e-06 26.7 0.1 9e-06 25.8 0.1 1.5 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EMD61362.1 - 3.5e-05 23.7 0.1 6.9e-05 22.8 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 EMD61362.1 - 5e-05 23.5 0.0 8.6e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EMD61362.1 - 0.00032 20.9 0.1 0.00053 20.1 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_5 PF16865.5 EMD61362.1 - 0.066 13.8 0.0 0.098 13.2 0.0 1.3 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain UBD PF16455.5 EMD61364.1 - 2.9e-27 94.9 0.1 4.3e-27 94.4 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin-binding domain ubiquitin PF00240.23 EMD61364.1 - 0.00027 20.6 0.0 0.00044 19.9 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EMD61364.1 - 0.0066 16.3 0.0 0.012 15.5 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 EMD61364.1 - 0.11 13.1 0.0 0.21 12.2 0.0 1.5 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain PH_6 PF15406.6 EMD61365.1 - 4.1e-31 107.6 2.0 4.1e-31 107.6 2.0 2.9 3 0 0 3 3 3 1 Pleckstrin homology domain PH PF00169.29 EMD61365.1 - 0.081 13.4 0.0 0.18 12.3 0.0 1.6 1 0 0 1 1 1 0 PH domain ATP_bind_3 PF01171.20 EMD61367.1 - 2.5e-44 151.2 0.0 4e-44 150.5 0.0 1.3 1 0 0 1 1 1 1 PP-loop family Asn_synthase PF00733.21 EMD61367.1 - 0.0014 18.4 0.5 0.0033 17.2 0.0 1.8 2 0 0 2 2 2 1 Asparagine synthase Cpn10 PF00166.21 EMD61368.1 - 2e-26 91.9 0.0 2.2e-26 91.7 0.0 1.0 1 0 0 1 1 1 1 Chaperonin 10 Kd subunit Het-C PF07217.11 EMD61369.1 - 5.1e-272 903.4 0.0 6.1e-272 903.2 0.0 1.0 1 0 0 1 1 1 1 Heterokaryon incompatibility protein Het-C Ank_3 PF13606.6 EMD61370.1 - 8.4e-20 68.8 0.1 3.1e-07 30.2 0.0 3.0 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.6 EMD61370.1 - 2.5e-19 69.3 0.4 2.7e-12 46.9 0.1 2.9 1 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 EMD61370.1 - 3.6e-18 65.9 0.1 1.3e-16 60.9 0.1 2.0 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EMD61370.1 - 2.4e-16 59.6 0.7 1.3e-08 35.0 0.0 3.0 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 EMD61370.1 - 7.5e-14 51.5 0.6 7e-06 26.3 0.0 3.1 3 0 0 3 3 3 3 Ankyrin repeat Strabismus PF06638.11 EMD61370.1 - 0.037 12.7 0.0 0.041 12.6 0.0 1.0 1 0 0 1 1 1 0 Strabismus protein Eno-Rase_FAD_bd PF07055.12 EMD61371.1 - 0.19 12.2 0.4 0.19 12.2 0.4 1.7 2 0 0 2 2 2 0 Enoyl reductase FAD binding domain DUF4288 PF14119.6 EMD61371.1 - 0.63 10.5 4.8 0.56 10.6 3.6 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4288) Vfa1 PF08432.10 EMD61371.1 - 1.1 9.6 11.3 1.4 9.3 11.3 1.0 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Ureide_permease PF07168.11 EMD61371.1 - 2.8 6.6 3.6 3 6.5 3.6 1.0 1 0 0 1 1 1 0 Ureide permease DUF4452 PF14618.6 EMD61373.1 - 3.4e-72 241.8 14.3 5.2e-72 241.2 14.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4452) Cyclin_N PF00134.23 EMD61374.1 - 7.1e-15 54.9 2.6 1.9e-11 43.8 0.4 2.6 2 2 0 2 2 2 2 Cyclin, N-terminal domain Cyclin_C_2 PF16899.5 EMD61374.1 - 0.02 15.3 0.4 0.062 13.7 0.4 1.8 1 0 0 1 1 1 0 Cyclin C-terminal domain Aconitase_B_N PF11791.8 EMD61374.1 - 0.033 14.2 0.1 0.065 13.3 0.1 1.4 1 0 0 1 1 1 0 Aconitate B N-terminal domain TFIIB PF00382.19 EMD61374.1 - 0.045 13.8 0.3 0.1 12.6 0.3 1.7 1 1 0 1 1 1 0 Transcription factor TFIIB repeat Mito_carr PF00153.27 EMD61375.1 - 1.2e-64 214.3 6.9 1.2e-21 76.4 0.3 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_7 PF13499.6 EMD61375.1 - 1.1e-24 86.7 2.7 3.2e-13 49.9 0.3 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 EMD61375.1 - 3.9e-24 82.4 1.2 2.1e-06 26.8 0.3 4.3 4 0 0 4 4 4 3 EF hand EF-hand_5 PF13202.6 EMD61375.1 - 1.4e-23 81.2 3.1 1.1e-06 27.8 0.0 3.4 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.6 EMD61375.1 - 4.9e-19 66.6 5.4 9e-07 28.3 0.0 4.4 4 0 0 4 4 4 3 EF-hand domain EF-hand_8 PF13833.6 EMD61375.1 - 4.2e-17 61.7 1.1 1.9e-08 34.0 0.0 3.6 1 1 3 4 4 4 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EMD61375.1 - 6.6e-11 42.5 0.0 4.6e-07 30.1 0.0 2.2 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 EMD61375.1 - 0.036 14.0 1.0 3.4 7.7 0.0 2.9 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand SNARE PF05739.19 EMD61376.1 - 6.4e-08 32.5 0.9 6.4e-08 32.5 0.9 2.0 2 0 0 2 2 2 1 SNARE domain Use1 PF09753.9 EMD61376.1 - 0.00024 20.9 0.2 0.00033 20.4 0.2 1.2 1 0 0 1 1 1 1 Membrane fusion protein Use1 HemX PF04375.14 EMD61376.1 - 0.032 13.5 6.5 0.077 12.3 0.4 2.2 2 0 0 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase Synaptobrevin PF00957.21 EMD61376.1 - 0.077 12.8 0.4 0.16 11.7 0.1 1.8 2 0 0 2 2 2 0 Synaptobrevin CorA PF01544.18 EMD61376.1 - 0.089 12.1 0.0 0.089 12.1 0.0 2.9 2 1 1 3 3 3 0 CorA-like Mg2+ transporter protein WXG100 PF06013.12 EMD61376.1 - 0.092 13.0 1.1 0.92 9.8 0.2 2.5 2 0 0 2 2 2 0 Proteins of 100 residues with WXG ABC_tran_CTD PF16326.5 EMD61376.1 - 0.27 11.5 1.6 2 8.8 0.3 2.7 2 1 1 3 3 3 0 ABC transporter C-terminal domain LPP PF04728.13 EMD61376.1 - 0.91 10.0 5.2 17 5.9 0.5 3.7 2 1 1 3 3 3 0 Lipoprotein leucine-zipper HrpB7 PF09486.10 EMD61376.1 - 1 9.7 5.7 2.8 8.3 0.4 2.7 2 1 0 2 2 2 0 Bacterial type III secretion protein (HrpB7) DUF4407 PF14362.6 EMD61376.1 - 1.9 7.8 7.0 9.4 5.5 6.9 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Mito_carr PF00153.27 EMD61377.1 - 3.3e-41 139.1 7.0 2.2e-17 62.8 0.6 4.4 3 2 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 EMD61377.1 - 0.0096 15.1 1.4 0.25 10.5 0.1 2.3 2 0 0 2 2 2 2 Gammaproteobacterial serine protease RIC1 PF07064.13 EMD61378.1 - 4.8e-96 321.0 0.1 7.7e-96 320.3 0.1 1.3 1 0 0 1 1 1 1 RIC1 Fungal_trans_2 PF11951.8 EMD61379.1 - 0.0079 15.0 1.5 0.027 13.3 0.1 2.3 2 1 0 2 2 2 1 Fungal specific transcription factor domain Inhibitor_I78 PF11720.8 EMD61380.1 - 1.6e-07 31.3 0.0 1.9e-07 31.0 0.0 1.1 1 0 0 1 1 1 1 Peptidase inhibitor I78 family potato_inhibit PF00280.18 EMD61380.1 - 0.00041 21.0 0.0 0.00048 20.8 0.0 1.2 1 0 0 1 1 1 1 Potato inhibitor I family CBFD_NFYB_HMF PF00808.23 EMD61381.1 - 3.1e-10 40.2 0.0 5.5e-10 39.4 0.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EMD61381.1 - 0.00018 21.9 1.3 0.00089 19.6 0.0 2.5 3 0 0 3 3 3 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 EMD61381.1 - 0.0038 17.3 0.1 0.0066 16.5 0.1 1.5 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TFIIA PF03153.13 EMD61381.1 - 0.11 12.5 13.4 0.12 12.4 13.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit BUD22 PF09073.10 EMD61381.1 - 0.12 11.7 15.2 0.13 11.6 15.2 1.1 1 0 0 1 1 1 0 BUD22 CENP-X PF09415.10 EMD61381.1 - 0.37 11.1 0.0 0.37 11.1 0.0 2.5 2 0 0 2 2 2 0 CENP-S associating Centromere protein X B3_4 PF03483.17 EMD61382.1 - 0.12 12.0 0.0 0.19 11.4 0.0 1.2 1 0 0 1 1 1 0 B3/4 domain SUZ PF12752.7 EMD61383.1 - 0.0001 23.0 12.0 0.0001 23.0 12.0 3.3 2 2 0 2 2 2 1 SUZ domain bZIP_1 PF00170.21 EMD61385.1 - 1.6e-06 28.1 1.5 1.6e-06 28.1 1.5 1.7 2 0 0 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.15 EMD61385.1 - 7.7e-05 22.7 4.2 0.00019 21.4 4.2 1.6 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 EMD61385.1 - 0.0059 17.1 1.3 0.01 16.3 1.3 1.3 1 0 0 1 1 1 1 bZIP Maf transcription factor Rbsn PF11464.8 EMD61385.1 - 0.018 14.8 0.1 0.034 13.9 0.1 1.4 1 0 0 1 1 1 0 Rabenosyn Rab binding domain DivIC PF04977.15 EMD61385.1 - 0.066 13.0 0.6 0.11 12.2 0.6 1.3 1 0 0 1 1 1 0 Septum formation initiator Zn_clus PF00172.18 EMD61386.1 - 1.1e-09 38.3 7.7 2.9e-09 36.9 7.7 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CK_II_beta PF01214.18 EMD61387.1 - 6.5e-76 254.2 0.2 8.5e-76 253.8 0.2 1.1 1 0 0 1 1 1 1 Casein kinase II regulatory subunit FYDLN_acid PF09538.10 EMD61387.1 - 0.01 16.5 1.0 0.01 16.5 1.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (FYDLN_acid) Trypan_PARP PF05887.11 EMD61388.1 - 3.1e-06 27.2 47.5 3.1e-06 27.2 47.5 20.5 7 3 11 20 20 20 3 Procyclic acidic repetitive protein (PARP) SLD3 PF08639.10 EMD61391.1 - 4.2e-142 474.7 8.0 5.3e-142 474.3 8.0 1.1 1 0 0 1 1 1 1 DNA replication regulator SLD3 MRJP PF03022.16 EMD61391.1 - 0.0016 17.9 0.0 0.0026 17.2 0.0 1.3 1 0 0 1 1 1 1 Major royal jelly protein 2-oxoacid_dh PF00198.23 EMD61392.1 - 1.9e-72 243.5 0.0 3.5e-72 242.6 0.0 1.4 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 EMD61392.1 - 1.5e-19 69.6 0.0 3.4e-19 68.4 0.0 1.6 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 EMD61392.1 - 2.5e-13 50.1 0.1 7.5e-13 48.6 0.0 1.9 2 0 0 2 2 2 1 e3 binding domain HlyD_D23 PF16576.5 EMD61392.1 - 0.0074 15.5 0.0 0.013 14.8 0.0 1.3 1 0 0 1 1 1 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion Biotin_lipoyl_2 PF13533.6 EMD61392.1 - 0.021 14.7 0.0 0.52 10.2 0.0 2.4 1 1 1 2 2 2 0 Biotin-lipoyl like Prefoldin_2 PF01920.20 EMD61393.1 - 3.7e-17 62.2 5.8 4e-17 62.1 5.0 1.4 1 1 0 1 1 1 1 Prefoldin subunit RasGAP_C PF03836.15 EMD61393.1 - 0.0063 16.7 5.7 0.21 11.7 0.4 2.3 2 1 0 2 2 2 2 RasGAP C-terminus Vac_Fusion PF02346.16 EMD61393.1 - 0.012 15.2 0.0 0.029 14.0 0.0 1.7 1 0 0 1 1 1 0 Chordopoxvirus multifunctional envelope protein A27 DUF3552 PF12072.8 EMD61393.1 - 0.016 14.6 0.3 0.016 14.6 0.3 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3552) bZIP_1 PF00170.21 EMD61393.1 - 0.061 13.4 2.8 0.061 13.4 2.8 2.0 3 0 0 3 3 3 0 bZIP transcription factor DUF4200 PF13863.6 EMD61393.1 - 0.068 13.6 7.7 1.5 9.2 0.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) APG6_N PF17675.1 EMD61393.1 - 0.46 11.0 7.3 2.2 8.8 0.4 2.1 2 0 0 2 2 2 0 Apg6 coiled-coil region Ceramidase PF05875.12 EMD61394.1 - 3.4e-109 364.3 10.6 3.9e-109 364.1 10.6 1.0 1 0 0 1 1 1 1 Ceramidase DUF2070 PF09843.9 EMD61394.1 - 0.018 13.4 3.4 0.03 12.6 3.4 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Tubulin PF00091.25 EMD61395.1 - 5.4e-69 232.3 0.0 3.3e-68 229.8 0.0 1.9 2 0 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EMD61395.1 - 1.4e-42 144.8 0.1 2.4e-42 144.1 0.1 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 EMD61395.1 - 5e-05 23.6 0.0 0.00015 22.1 0.0 1.8 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_2 PF13809.6 EMD61395.1 - 0.00062 19.1 0.0 0.0087 15.3 0.0 2.1 2 0 0 2 2 2 1 Tubulin like Tubulin_3 PF14881.6 EMD61395.1 - 0.0029 17.3 0.0 0.0054 16.4 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain HMG_box_2 PF09011.10 EMD61396.1 - 8.8e-08 32.6 9.9 5e-06 27.0 0.1 3.5 3 1 1 4 4 4 2 HMG-box domain HMG_box PF00505.19 EMD61396.1 - 2e-05 24.9 0.4 2e-05 24.9 0.4 3.9 4 2 1 5 5 5 2 HMG (high mobility group) box DUF4065 PF13274.6 EMD61396.1 - 0.71 10.8 5.3 3.1 8.7 5.2 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF4065) CDK5_activator PF03261.15 EMD61396.1 - 3.2 7.2 15.4 5.1 6.5 15.4 1.3 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein Aminotran_4 PF01063.19 EMD61397.1 - 9.3e-35 120.5 0.0 1.2e-34 120.2 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV Pkinase PF00069.25 EMD61398.1 - 9.9e-19 67.7 0.0 2.2e-18 66.6 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD61398.1 - 6.3e-09 35.5 0.0 5.6e-08 32.4 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase DCB PF16213.5 EMD61398.1 - 0.025 14.3 0.1 0.063 12.9 0.1 1.6 1 0 0 1 1 1 0 Dimerisation and cyclophilin-binding domain of Mon2 Aa_trans PF01490.18 EMD61399.1 - 6.5e-27 94.3 33.9 8.2e-27 93.9 33.9 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein NACHT PF05729.12 EMD61400.1 - 8.5e-06 25.8 0.0 1.9e-05 24.7 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 EMD61400.1 - 5e-05 23.6 0.1 0.00084 19.6 0.0 2.7 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.6 EMD61400.1 - 0.00028 21.3 0.1 0.002 18.5 0.0 2.5 3 1 0 3 3 3 1 AAA ATPase domain AAA PF00004.29 EMD61400.1 - 0.01 16.2 0.0 0.035 14.5 0.0 1.9 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 EMD61400.1 - 0.014 15.8 0.0 0.049 14.0 0.0 2.0 1 0 0 1 1 1 0 RNA helicase DUF2075 PF09848.9 EMD61400.1 - 0.015 14.5 0.3 0.037 13.3 0.0 1.8 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) DUF429 PF04250.13 EMD61400.1 - 0.025 14.4 0.0 0.058 13.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF429) AAA_25 PF13481.6 EMD61400.1 - 0.035 13.7 0.0 0.074 12.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain PEMT PF04191.13 EMD61401.1 - 8.9e-33 112.9 1.8 1.3e-32 112.3 1.0 1.6 2 0 0 2 2 2 1 Phospholipid methyltransferase DUF2374 PF09574.10 EMD61401.1 - 0.53 10.1 5.8 2.4 8.1 0.3 2.8 2 1 0 2 2 2 0 Protein of unknown function (Duf2374) PAP2 PF01569.21 EMD61402.1 - 1.1e-25 89.9 3.5 1.1e-25 89.9 3.5 2.8 2 1 0 2 2 2 1 PAP2 superfamily Sulf_transp PF04143.14 EMD61402.1 - 0.02 14.5 0.3 0.02 14.5 0.3 2.0 3 0 0 3 3 3 0 Sulphur transport Ank_5 PF13857.6 EMD61403.1 - 5e-09 36.2 0.1 5.7e-06 26.5 0.1 2.3 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 EMD61403.1 - 1.5e-07 31.8 0.0 1.9e-05 25.1 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EMD61403.1 - 6.4e-06 26.7 0.1 1e-05 26.0 0.1 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EMD61403.1 - 8.7e-06 25.7 0.1 0.0015 18.8 0.1 3.0 3 0 0 3 3 3 1 Ankyrin repeat Ank PF00023.30 EMD61403.1 - 3.4e-05 24.1 0.0 0.026 15.0 0.1 2.6 2 0 0 2 2 2 2 Ankyrin repeat DUF3808 PF10300.9 EMD61404.1 - 8.1e-138 460.1 0.2 1e-137 459.8 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3808) TPR_2 PF07719.17 EMD61404.1 - 0.0053 16.8 11.8 0.48 10.7 0.2 5.5 6 1 0 6 6 6 2 Tetratricopeptide repeat DUF2786 PF10979.8 EMD61404.1 - 0.031 14.2 0.2 0.73 9.8 0.0 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2786) SURF2 PF05477.11 EMD61404.1 - 0.035 13.8 2.4 0.056 13.1 2.4 1.2 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) TPR_5 PF12688.7 EMD61404.1 - 0.064 13.5 0.0 0.48 10.7 0.0 2.4 2 0 0 2 2 2 0 Tetratrico peptide repeat TPR_1 PF00515.28 EMD61404.1 - 0.11 12.4 1.7 34 4.5 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat zf-C2H2_assoc3 PF16637.5 EMD61404.1 - 0.2 11.9 3.1 0.66 10.2 3.1 1.8 1 0 0 1 1 1 0 Putative zinc-finger between two C2H2 zinc-fingers on Patz TPR_8 PF13181.6 EMD61404.1 - 0.77 10.1 6.7 36 4.9 0.0 5.4 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_6 PF13174.6 EMD61404.1 - 1.3 9.8 3.9 95 4.0 0.0 5.2 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_12 PF13424.6 EMD61404.1 - 2.8 8.3 12.2 4.4 7.7 0.2 4.5 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_19 PF14559.6 EMD61404.1 - 4.6 7.8 6.0 32 5.1 0.0 3.9 5 0 0 5 5 4 0 Tetratricopeptide repeat DSS1_SEM1 PF05160.13 EMD61405.1 - 2.4e-23 81.9 13.7 3.2e-23 81.5 13.7 1.2 1 0 0 1 1 1 1 DSS1/SEM1 family PGK PF00162.19 EMD61406.1 - 3.5e-151 503.5 2.1 3.9e-151 503.3 2.1 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase PA PF02225.22 EMD61406.1 - 0.0053 16.7 1.6 0.19 11.8 0.0 2.8 3 0 0 3 3 3 1 PA domain DUF3530 PF12048.8 EMD61406.1 - 0.031 13.7 0.0 0.043 13.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3530) Mpv17_PMP22 PF04117.12 EMD61407.1 - 1e-20 73.7 0.1 2.7e-20 72.3 0.1 1.8 1 0 0 1 1 1 1 Mpv17 / PMP22 family Trs65 PF12735.7 EMD61408.1 - 5.5e-81 272.4 0.6 7e-81 272.1 0.6 1.1 1 0 0 1 1 1 1 TRAPP trafficking subunit Trs65 FF PF01846.19 EMD61409.1 - 8.4e-45 150.7 15.9 1.3e-12 47.7 1.7 6.7 6 0 0 6 6 6 5 FF domain WW PF00397.26 EMD61409.1 - 1.6e-11 44.1 16.2 7e-07 29.2 6.8 2.9 2 0 0 2 2 2 2 WW domain RhoGAP-FF1 PF16512.5 EMD61409.1 - 0.011 16.4 13.2 0.39 11.4 2.2 4.7 2 1 2 4 4 4 0 p190-A and -B Rho GAPs FF domain DUF3878 PF12994.7 EMD61409.1 - 0.017 14.6 1.0 0.068 12.6 0.9 2.0 1 1 1 2 2 2 0 Domain of unknown function, E. rectale Gene description (DUF3878) DUF5338 PF17273.2 EMD61409.1 - 0.024 14.7 0.5 0.17 12.0 0.4 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5338) Acyl-CoA_dh_1 PF00441.24 EMD61410.1 - 5.1e-30 104.7 1.2 7.4e-30 104.1 1.2 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 EMD61410.1 - 1.6e-22 79.5 0.1 3.1e-22 78.6 0.1 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 EMD61410.1 - 1.1e-15 58.2 1.1 6.6e-15 55.7 0.3 2.6 2 1 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 EMD61410.1 - 7.5e-06 26.2 0.2 1.3e-05 25.5 0.2 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain DUF1447 PF07288.11 EMD61411.1 - 0.11 12.6 0.3 0.18 11.9 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1447) Fungal_trans PF04082.18 EMD61412.1 - 1.6e-33 115.9 0.2 4.8e-33 114.3 0.1 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD61412.1 - 0.00025 21.1 15.5 0.00042 20.4 15.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fe-S_assembly PF04384.13 EMD61412.1 - 0.15 12.7 0.0 0.41 11.3 0.0 1.7 1 0 0 1 1 1 0 Iron-sulphur cluster assembly Choline_kinase PF01633.20 EMD61413.1 - 3.7e-51 173.7 0.0 9.8e-49 165.8 0.0 2.1 2 0 0 2 2 2 2 Choline/ethanolamine kinase APH PF01636.23 EMD61413.1 - 1.6e-08 34.8 0.0 1.1e-07 32.0 0.0 2.3 2 1 0 2 2 2 1 Phosphotransferase enzyme family Sterol-sensing PF12349.8 EMD61414.1 - 3.3e-31 108.2 3.8 8.9e-31 106.8 3.8 1.8 1 0 0 1 1 1 1 Sterol-sensing domain of SREBP cleavage-activation Patched PF02460.18 EMD61414.1 - 8.3e-10 37.4 3.6 1.4e-09 36.7 3.6 1.2 1 0 0 1 1 1 1 Patched family TPR_12 PF13424.6 EMD61414.1 - 1.9e-09 37.7 0.2 0.00014 22.0 0.0 4.6 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 EMD61414.1 - 1.1e-07 31.4 0.0 0.0044 17.0 0.0 5.0 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_14 PF13428.6 EMD61414.1 - 8.1e-07 29.3 3.1 1.4 9.9 0.0 5.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 EMD61414.1 - 2.3e-05 24.2 0.0 0.017 15.3 0.0 4.6 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_16 PF13432.6 EMD61414.1 - 0.0001 22.9 1.9 1.3 9.7 0.6 4.0 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 EMD61414.1 - 0.00027 20.6 0.7 0.027 14.3 0.0 3.9 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_9 PF13371.6 EMD61414.1 - 0.0059 16.7 7.5 0.19 11.9 0.2 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 EMD61414.1 - 0.016 15.7 5.4 0.33 11.5 0.1 3.7 2 2 1 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 EMD61414.1 - 0.019 15.6 1.3 20 6.1 0.0 4.6 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_MalT PF17874.1 EMD61414.1 - 0.044 13.2 0.4 0.3 10.4 0.1 2.2 2 0 0 2 2 2 0 MalT-like TPR region TPR_21 PF09976.9 EMD61414.1 - 0.38 10.4 1.7 0.79 9.4 0.2 2.2 2 1 0 2 2 2 0 Tetratricopeptide repeat-like domain CENP-B_dimeris PF09026.10 EMD61414.1 - 0.61 10.5 4.1 2.2 8.7 4.1 1.9 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Complex1_LYR PF05347.15 EMD61415.1 - 6.5e-13 48.5 0.2 1.6e-12 47.3 0.2 1.7 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 EMD61415.1 - 0.0053 17.5 1.8 0.015 16.0 0.0 2.4 2 1 0 2 2 2 1 Complex1_LYR-like UQ_con PF00179.26 EMD61416.1 - 4.9e-17 61.9 0.0 5.3e-17 61.8 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EMD61416.1 - 0.014 15.6 0.0 0.015 15.6 0.0 1.2 1 0 0 1 1 1 0 RWD domain DCB PF16213.5 EMD61417.1 - 9.1e-42 142.7 0.9 9.1e-42 142.7 0.9 2.2 2 0 0 2 2 2 1 Dimerisation and cyclophilin-binding domain of Mon2 Sec7_N PF12783.7 EMD61417.1 - 6.1e-40 136.7 0.8 6.1e-40 136.7 0.8 5.0 5 1 0 5 5 5 1 Guanine nucleotide exchange factor in Golgi transport N-terminal Mon2_C PF16206.5 EMD61417.1 - 5.7e-14 51.2 3.7 1.8e-12 46.3 1.2 2.6 3 0 0 3 3 3 2 C-terminal region of Mon2 protein DUF1981 PF09324.10 EMD61417.1 - 4.7e-05 23.2 5.0 2.6 8.0 0.0 6.7 8 0 0 8 8 8 2 Domain of unknown function (DUF1981) Ipi1_N PF12333.8 EMD61417.1 - 0.0085 16.7 3.4 7.2 7.3 0.0 4.4 4 0 0 4 4 4 2 Rix1 complex component involved in 60S ribosome maturation HEAT PF02985.22 EMD61417.1 - 0.4 11.1 5.5 27 5.4 0.0 4.9 4 0 0 4 4 4 0 HEAT repeat Fungal_trans PF04082.18 EMD61418.1 - 2e-13 50.0 0.1 4.2e-13 48.9 0.1 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD61418.1 - 3.3e-08 33.5 14.0 5.6e-08 32.8 14.0 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TolA_bind_tri PF16331.5 EMD61418.1 - 0.061 13.4 0.2 0.13 12.4 0.2 1.5 1 0 0 1 1 1 0 TolA binding protein trimerisation CK_II_beta PF01214.18 EMD61419.1 - 2e-76 255.9 0.0 5e-76 254.6 0.0 1.6 1 1 0 1 1 1 1 Casein kinase II regulatory subunit Spt5_N PF11942.8 EMD61419.1 - 0.053 14.5 15.8 0.15 13.0 5.8 2.4 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal Pox_Ag35 PF03286.14 EMD61419.1 - 0.84 9.4 5.9 11 5.7 1.4 2.2 2 0 0 2 2 2 0 Pox virus Ag35 surface protein CENP-B_dimeris PF09026.10 EMD61419.1 - 6.3 7.3 18.8 10 6.6 9.9 2.6 3 0 0 3 3 3 0 Centromere protein B dimerisation domain DUF4637 PF15470.6 EMD61419.1 - 8.2 6.1 9.7 0.38 10.5 2.7 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4637) Ammonium_transp PF00909.21 EMD61420.1 - 1.3e-114 383.0 25.4 1.5e-114 382.8 25.4 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family Tfb4 PF03850.14 EMD61421.1 - 9.6e-106 353.3 0.0 1.1e-105 353.0 0.0 1.0 1 0 0 1 1 1 1 Transcription factor Tfb4 zf-C2HC5 PF06221.13 EMD61421.1 - 1.4 9.0 5.1 2.3 8.3 5.1 1.3 1 0 0 1 1 1 0 Putative zinc finger motif, C2HC5-type FMO-like PF00743.19 EMD61422.1 - 7.5e-11 41.1 0.4 2.1e-10 39.6 0.4 1.6 1 1 0 1 1 1 1 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.6 EMD61422.1 - 6.2e-09 36.0 0.0 1.7e-08 34.6 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 EMD61422.1 - 3e-07 30.0 0.7 0.001 18.4 0.1 2.7 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EMD61422.1 - 4.3e-07 29.4 0.0 5.7e-05 22.4 0.0 2.3 2 0 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) Thi4 PF01946.17 EMD61422.1 - 0.00034 19.9 0.2 0.0039 16.5 0.1 2.3 2 0 0 2 2 2 1 Thi4 family Pyr_redox_2 PF07992.14 EMD61422.1 - 0.0092 15.2 1.1 0.054 12.7 0.7 2.3 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EMD61422.1 - 0.021 14.4 1.2 0.16 11.5 1.0 2.5 2 1 0 2 2 2 0 FAD dependent oxidoreductase HI0933_like PF03486.14 EMD61422.1 - 0.066 11.9 0.2 0.12 11.0 0.2 1.4 1 0 0 1 1 1 0 HI0933-like protein NAD_binding_9 PF13454.6 EMD61422.1 - 0.11 12.4 0.0 0.55 10.2 0.0 2.1 2 0 0 2 2 2 0 FAD-NAD(P)-binding FAD_binding_2 PF00890.24 EMD61422.1 - 0.22 10.6 0.2 0.45 9.5 0.2 1.5 1 0 0 1 1 1 0 FAD binding domain Skp1_POZ PF03931.15 EMD61423.1 - 1.9e-10 40.8 0.0 2.7e-10 40.3 0.0 1.2 1 0 0 1 1 1 1 Skp1 family, tetramerisation domain adh_short PF00106.25 EMD61424.1 - 2.7e-44 151.0 0.0 6.6e-34 117.1 0.1 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EMD61424.1 - 6.3e-38 130.6 0.0 5.9e-35 120.9 0.1 2.0 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD61424.1 - 5.7e-05 23.1 1.5 0.00083 19.3 1.5 2.7 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 EMD61424.1 - 0.039 13.4 0.1 0.12 11.9 0.1 1.9 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Med12-LCEWAV PF12145.8 EMD61424.1 - 0.11 11.4 0.0 0.13 11.1 0.0 1.2 1 0 0 1 1 1 0 Eukaryotic Mediator 12 subunit domain 3HCDH_N PF02737.18 EMD61424.1 - 0.12 12.2 0.0 0.27 11.1 0.0 1.5 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ThiF PF00899.21 EMD61425.1 - 4.8e-73 245.5 0.1 6.9e-73 245.0 0.1 1.1 1 0 0 1 1 1 1 ThiF family UAE_UbL PF14732.6 EMD61425.1 - 6.7e-18 65.1 2.9 1.6e-17 63.8 2.9 1.7 1 0 0 1 1 1 1 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain UBA_e1_thiolCys PF10585.9 EMD61425.1 - 9.7e-09 35.5 0.9 0.00037 20.5 0.1 2.7 1 1 1 2 2 2 2 Ubiquitin-activating enzyme active site NAD_binding_7 PF13241.6 EMD61425.1 - 0.00036 20.9 0.6 0.0039 17.6 0.0 2.8 3 0 0 3 3 3 1 Putative NAD(P)-binding Shikimate_DH PF01488.20 EMD61425.1 - 0.0073 16.4 0.3 0.021 14.9 0.1 1.9 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase Sacchrp_dh_NADP PF03435.18 EMD61425.1 - 0.051 13.8 0.7 0.39 11.0 0.5 2.5 2 1 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain Q_salvage PF10343.9 EMD61426.1 - 1e-129 432.1 0.2 1.2e-129 431.8 0.2 1.1 1 0 0 1 1 1 1 Potential Queuosine, Q, salvage protein family DUF4121 PF13497.6 EMD61426.1 - 0.02 14.0 0.3 0.035 13.3 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4121) FAD_binding_4 PF01565.23 EMD61427.1 - 8.6e-31 106.5 2.3 1.5e-30 105.7 2.3 1.4 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EMD61427.1 - 1.7e-11 44.0 0.0 4.7e-11 42.6 0.0 1.8 1 0 0 1 1 1 1 Berberine and berberine like Ribonucleas_3_3 PF14622.6 EMD61429.1 - 3.4e-06 27.3 0.0 9.1e-06 25.9 0.0 1.7 1 0 0 1 1 1 1 Ribonuclease-III-like Ribonuclease_3 PF00636.26 EMD61429.1 - 5.9e-05 23.6 1.0 0.00049 20.7 0.1 2.8 2 1 0 2 2 2 1 Ribonuclease III domain tRNA-synt_2b PF00587.25 EMD61430.1 - 2.8e-33 115.4 0.0 4.2e-33 114.8 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 EMD61430.1 - 7.9e-09 35.6 0.1 2.3e-08 34.1 0.1 1.8 1 0 0 1 1 1 1 Anticodon binding domain Ribosomal_L10 PF00466.20 EMD61431.1 - 1.7e-05 24.9 0.5 0.0019 18.3 0.5 2.8 1 1 0 1 1 1 1 Ribosomal protein L10 Rox3 PF08633.10 EMD61432.1 - 5.6e-54 183.6 0.0 9.4e-54 182.8 0.0 1.4 1 0 0 1 1 1 1 Rox3 mediator complex subunit Rad10 PF03834.14 EMD61433.1 - 3e-49 165.8 0.0 4.5e-49 165.2 0.0 1.3 1 0 0 1 1 1 1 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) HHH_5 PF14520.6 EMD61433.1 - 0.0034 18.0 0.0 0.006 17.2 0.0 1.4 1 0 0 1 1 1 1 Helix-hairpin-helix domain Sugar_tr PF00083.24 EMD61434.1 - 5.7e-96 322.1 26.6 6.6e-96 321.9 26.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD61434.1 - 3.6e-31 108.4 28.8 5.9e-24 84.7 5.2 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EMD61434.1 - 0.0036 15.9 5.3 0.0036 15.9 5.3 3.3 2 2 1 3 3 3 2 MFS/sugar transport protein OATP PF03137.20 EMD61434.1 - 0.022 13.1 8.6 0.0041 15.5 3.4 2.3 1 1 1 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family TMA7 PF09072.10 EMD61435.1 - 1.7e-15 57.6 13.1 1.8e-15 57.5 13.1 1.0 1 0 0 1 1 1 1 Translation machinery associated TMA7 DBR1 PF05011.13 EMD61437.1 - 2.8e-47 160.7 1.7 2.9e-47 160.6 0.5 1.7 2 0 0 2 2 2 1 Lariat debranching enzyme, C-terminal domain Metallophos PF00149.28 EMD61437.1 - 1.7e-05 25.4 0.5 6.1e-05 23.6 0.3 1.9 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Rpr2 PF04032.16 EMD61438.1 - 6.9e-14 51.9 1.1 7.8e-14 51.7 0.0 1.7 3 0 0 3 3 3 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain Nudix_N_2 PF14803.6 EMD61438.1 - 0.0082 16.0 0.1 0.86 9.6 0.0 2.4 2 0 0 2 2 2 1 Nudix N-terminal zf-piccolo PF05715.13 EMD61438.1 - 0.11 12.7 0.4 16 5.7 0.1 2.4 2 0 0 2 2 2 0 Piccolo Zn-finger CD24 PF14984.6 EMD61438.1 - 0.15 12.3 0.2 2.2 8.6 0.5 2.2 2 0 0 2 2 2 0 CD24 protein DUF4672 PF15716.5 EMD61438.1 - 0.15 11.7 2.6 0.2 11.2 2.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4672) zf-ZPR1 PF03367.13 EMD61439.1 - 2.2e-115 381.9 2.0 4.9e-58 195.5 0.2 2.1 2 0 0 2 2 2 2 ZPR1 zinc-finger domain HypA PF01155.19 EMD61439.1 - 0.023 14.7 3.0 2.8 8.0 0.4 2.7 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Baculo_PEP_C PF04513.12 EMD61439.1 - 0.13 12.3 0.1 23 5.0 0.0 2.3 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus zf-RRPl_C4 PF17026.5 EMD61439.1 - 0.2 11.8 1.6 7.4 6.7 0.4 2.3 2 0 0 2 2 2 0 Putative ribonucleoprotein zinc-finger pf C4 type DSBA PF01323.20 EMD61439.1 - 0.23 11.2 0.8 6.2 6.5 0.1 2.6 2 1 0 2 2 2 0 DSBA-like thioredoxin domain Cytochrome_C7 PF14522.6 EMD61439.1 - 0.31 11.1 4.2 0.21 11.6 0.3 2.5 2 1 0 2 2 2 0 Cytochrome c7 and related cytochrome c zinc-ribbons_6 PF07191.12 EMD61439.1 - 2.6 8.1 6.1 4.7 7.3 1.1 2.5 2 1 0 2 2 2 0 zinc-ribbons HNH PF01844.23 EMD61439.1 - 5.9 7.2 8.7 1.3 9.3 0.1 3.0 3 0 0 3 3 3 0 HNH endonuclease Arrestin_C PF02752.22 EMD61440.1 - 6.4e-13 49.3 0.0 1.8e-12 47.9 0.0 1.8 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Fe_hyd_lg_C PF02906.14 EMD61441.1 - 4.3e-51 173.9 0.0 8.5e-51 173.0 0.0 1.5 1 1 0 1 1 1 1 Iron only hydrogenase large subunit, C-terminal domain Pkinase PF00069.25 EMD61442.1 - 2.3e-54 184.5 0.0 3.6e-54 183.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD61442.1 - 5.1e-30 104.6 0.0 3e-29 102.1 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EMD61442.1 - 0.013 14.4 0.0 0.027 13.4 0.0 1.4 1 0 0 1 1 1 0 Haspin like kinase domain Pox_ser-thr_kin PF05445.11 EMD61442.1 - 0.062 12.3 0.0 0.092 11.7 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase PAN_3 PF08277.12 EMD61444.1 - 0.064 13.1 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 PAN-like domain Rubredoxin_2 PF18073.1 EMD61444.1 - 0.48 10.2 3.5 0.23 11.2 1.3 1.7 2 0 0 2 2 2 0 Rubredoxin metal binding domain Kinesin PF00225.23 EMD61446.1 - 5e-91 305.1 1.4 1.2e-90 303.9 0.0 2.4 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 EMD61446.1 - 2.7e-20 72.8 0.8 6.3e-16 58.7 0.0 4.0 3 1 0 4 4 4 2 Microtubule binding UPF0242 PF06785.11 EMD61446.1 - 0.0011 19.1 14.1 0.0011 19.1 14.1 10.8 4 2 6 10 10 10 2 Uncharacterised protein family (UPF0242) N-terminus DUF3800 PF12686.7 EMD61446.1 - 0.012 16.3 0.1 49 4.6 0.0 5.2 2 2 0 2 2 2 0 Protein of unknown function (DUF3800) WD40_alt PF14077.6 EMD61446.1 - 3.1 7.7 9.2 5.5 6.9 0.2 3.7 3 0 0 3 3 3 0 Alternative WD40 repeat motif TPR_12 PF13424.6 EMD61447.1 - 6.1e-48 161.0 11.5 7.6e-15 55.0 0.1 5.2 2 1 3 5 5 5 4 Tetratricopeptide repeat TPR_10 PF13374.6 EMD61447.1 - 8.7e-48 159.0 2.3 5.8e-13 48.3 0.0 5.1 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_7 PF13176.6 EMD61447.1 - 3.2e-14 51.8 2.0 0.0059 16.6 0.1 5.1 4 0 0 4 4 4 4 Tetratricopeptide repeat NB-ARC PF00931.22 EMD61447.1 - 8.9e-14 51.3 0.3 7.5e-13 48.3 0.1 2.2 2 0 0 2 2 2 1 NB-ARC domain TPR_1 PF00515.28 EMD61447.1 - 4.4e-09 35.8 0.6 0.34 10.8 0.0 4.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 EMD61447.1 - 1.2e-07 31.3 6.0 1.2 9.4 0.0 5.0 5 0 0 5 5 4 3 Tetratricopeptide repeat AAA_16 PF13191.6 EMD61447.1 - 1.4e-06 28.8 0.2 1.4e-06 28.8 0.2 3.0 3 1 0 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 EMD61447.1 - 2.5e-06 27.8 0.2 1.1e-05 25.7 0.0 2.3 2 0 0 2 2 1 1 AAA domain NACHT PF05729.12 EMD61447.1 - 9.8e-06 25.6 0.1 3.2e-05 23.9 0.0 2.0 2 0 0 2 2 1 1 NACHT domain TPR_4 PF07721.14 EMD61447.1 - 3e-05 24.2 2.3 0.21 12.3 0.0 4.3 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 EMD61447.1 - 3.8e-05 24.1 8.3 0.47 11.0 0.0 5.2 4 1 1 5 5 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 EMD61447.1 - 0.00018 22.1 5.4 3.4 8.4 0.0 5.6 5 2 1 6 6 4 1 Tetratricopeptide repeat AAA PF00004.29 EMD61447.1 - 0.00032 21.1 0.0 0.00089 19.7 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) TniB PF05621.11 EMD61447.1 - 0.00039 19.9 0.0 0.0013 18.2 0.0 1.8 2 0 0 2 2 2 1 Bacterial TniB protein IstB_IS21 PF01695.17 EMD61447.1 - 0.00046 20.0 0.0 0.0012 18.6 0.0 1.7 1 0 0 1 1 1 1 IstB-like ATP binding protein TPR_8 PF13181.6 EMD61447.1 - 0.00069 19.6 0.7 2.4 8.6 0.0 4.1 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_3 PF07720.12 EMD61447.1 - 0.0013 18.6 0.1 0.026 14.5 0.2 2.9 3 0 0 3 3 2 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EMD61447.1 - 0.0017 18.5 1.7 0.18 12.1 0.3 3.9 1 1 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 AAA_24 PF13479.6 EMD61447.1 - 0.0042 16.8 0.0 0.013 15.2 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 EMD61447.1 - 0.012 15.6 0.0 0.046 13.7 0.0 2.0 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) ABC_tran PF00005.27 EMD61447.1 - 0.013 16.0 0.0 0.14 12.6 0.0 2.5 2 0 0 2 2 2 0 ABC transporter AAA_33 PF13671.6 EMD61447.1 - 0.015 15.5 0.9 0.59 10.3 0.1 3.1 2 1 0 2 2 2 0 AAA domain AAA_18 PF13238.6 EMD61447.1 - 0.015 15.8 0.1 0.067 13.7 0.0 2.2 2 0 0 2 2 1 0 AAA domain AAA_25 PF13481.6 EMD61447.1 - 0.028 14.0 0.0 0.083 12.5 0.0 1.8 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EMD61447.1 - 0.056 13.8 0.0 0.16 12.4 0.0 1.8 1 0 0 1 1 1 0 RNA helicase CaATP_NAI PF12515.8 EMD61447.1 - 0.088 12.4 0.4 2.1 8.0 0.0 2.7 2 0 0 2 2 2 0 Ca2+-ATPase N terminal autoinhibitory domain Pox_A32 PF04665.12 EMD61447.1 - 0.13 11.7 0.1 20 4.5 0.0 2.4 2 0 0 2 2 2 0 Poxvirus A32 protein MMR_HSR1 PF01926.23 EMD61447.1 - 0.17 12.0 0.0 0.6 10.2 0.0 2.0 1 0 0 1 1 1 0 50S ribosome-binding GTPase TPR_14 PF13428.6 EMD61447.1 - 0.27 12.1 8.2 6.5 7.9 0.0 5.4 5 0 0 5 5 5 0 Tetratricopeptide repeat AAA_28 PF13521.6 EMD61447.1 - 0.31 11.2 2.9 0.77 10.0 0.0 3.0 3 1 1 4 4 4 0 AAA domain TPR_17 PF13431.6 EMD61447.1 - 0.8 10.2 3.4 80 4.0 0.1 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat RPN6_N PF18055.1 EMD61447.1 - 1.3 9.4 5.6 2.6 8.4 0.1 3.7 3 2 1 4 4 4 0 26S proteasome regulatory subunit RPN6 N-terminal domain TPR_6 PF13174.6 EMD61447.1 - 1.6 9.5 8.9 9.5 7.1 0.1 5.4 6 0 0 6 6 4 0 Tetratricopeptide repeat CSTF2_hinge PF14327.6 EMD61447.1 - 3.2 8.3 6.9 0.29 11.6 0.6 2.5 3 0 0 3 3 2 0 Hinge domain of cleavage stimulation factor subunit 2 DENN PF02141.21 EMD61448.1 - 1e-41 142.9 0.1 1.9e-41 142.1 0.1 1.4 1 0 0 1 1 1 1 DENN (AEX-3) domain uDENN PF03456.18 EMD61448.1 - 5.3e-06 27.1 0.0 1.7e-05 25.4 0.0 2.0 1 0 0 1 1 1 1 uDENN domain Elongin_A PF06881.11 EMD61448.1 - 0.0028 18.2 5.6 0.013 16.0 5.6 2.1 1 0 0 1 1 1 1 RNA polymerase II transcription factor SIII (Elongin) subunit A DUF724 PF05266.14 EMD61448.1 - 3.4 7.5 12.7 5.8 6.7 12.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF724) zf-HIT PF04438.16 EMD61449.1 - 6.7e-10 38.7 11.2 1.1e-09 38.0 11.2 1.3 1 0 0 1 1 1 1 HIT zinc finger Sdh5 PF03937.16 EMD61449.1 - 0.012 15.6 0.1 0.02 14.8 0.1 1.4 1 0 0 1 1 1 0 Flavinator of succinate dehydrogenase APS_kinase PF01583.20 EMD61450.1 - 1.1e-71 239.9 0.0 1.3e-71 239.6 0.0 1.1 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_33 PF13671.6 EMD61450.1 - 5.6e-06 26.6 0.0 9.8e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EMD61450.1 - 0.00013 22.5 0.0 0.00018 22.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.10 EMD61450.1 - 0.0024 17.4 0.0 0.0028 17.2 0.0 1.2 1 0 0 1 1 1 1 Chromatin associated protein KTI12 TctC PF03401.14 EMD61450.1 - 0.041 13.0 0.0 0.05 12.7 0.0 1.1 1 0 0 1 1 1 0 Tripartite tricarboxylate transporter family receptor AAA_29 PF13555.6 EMD61450.1 - 0.049 13.4 0.0 0.082 12.7 0.0 1.3 1 0 0 1 1 1 0 P-loop containing region of AAA domain G-alpha PF00503.20 EMD61450.1 - 0.058 12.5 0.0 0.069 12.3 0.0 1.2 1 0 0 1 1 1 0 G-protein alpha subunit 6PF2K PF01591.18 EMD61450.1 - 0.093 12.0 0.0 0.12 11.6 0.0 1.2 1 0 0 1 1 1 0 6-phosphofructo-2-kinase AAA_16 PF13191.6 EMD61450.1 - 0.12 12.7 0.1 0.18 12.2 0.1 1.3 1 1 0 1 1 1 0 AAA ATPase domain DUF463 PF04317.12 EMD61450.1 - 0.13 11.2 0.0 0.15 11.0 0.0 1.2 1 0 0 1 1 1 0 YcjX-like family, DUF463 DUF3336 PF11815.8 EMD61451.1 - 7.7e-34 116.4 2.7 7.7e-34 116.4 2.7 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF3336) Patatin PF01734.22 EMD61451.1 - 2.5e-19 70.3 0.4 5.8e-19 69.1 0.1 1.7 2 0 0 2 2 2 1 Patatin-like phospholipase Rubella_Capsid PF05750.11 EMD61451.1 - 0.082 12.5 0.8 0.13 11.8 0.8 1.2 1 0 0 1 1 1 0 Rubella capsid protein CPDase PF07823.11 EMD61452.1 - 5.4e-35 120.9 0.0 6.2e-35 120.7 0.0 1.0 1 0 0 1 1 1 1 Cyclic phosphodiesterase-like protein 2_5_RNA_ligase2 PF13563.6 EMD61452.1 - 7.8e-05 22.6 0.0 0.038 13.9 0.0 2.4 1 1 1 3 3 3 2 2'-5' RNA ligase superfamily AKAP7_NLS PF10469.9 EMD61452.1 - 0.16 11.9 0.0 0.3 10.9 0.0 1.4 2 0 0 2 2 2 0 AKAP7 2'5' RNA ligase-like domain EF-hand_5 PF13202.6 EMD61453.1 - 3.3e-05 23.2 6.1 0.57 9.8 0.1 3.4 3 0 0 3 3 3 3 EF hand Dockerin_1 PF00404.18 EMD61453.1 - 4.3e-05 23.6 5.1 0.02 15.1 1.1 2.7 2 1 0 2 2 2 2 Dockerin type I domain EF-hand_1 PF00036.32 EMD61453.1 - 0.00014 21.2 4.1 1.6 8.5 0.1 3.5 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.6 EMD61453.1 - 0.00016 21.3 6.1 1.9 8.6 0.1 3.7 3 0 0 3 3 3 3 EF-hand domain EF-hand_7 PF13499.6 EMD61453.1 - 0.0005 20.5 1.3 7.9 7.0 0.0 3.6 3 0 0 3 3 3 2 EF-hand domain pair AA_permease PF00324.21 EMD61455.1 - 4.1e-116 388.4 34.4 5.1e-116 388.1 34.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EMD61455.1 - 1.4e-20 73.6 35.6 1.9e-20 73.1 35.6 1.2 1 0 0 1 1 1 1 Amino acid permease Pkinase PF00069.25 EMD61457.1 - 3.3e-33 115.2 0.0 2.4e-20 73.0 0.0 2.4 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EMD61457.1 - 2.2e-16 59.9 0.0 5.6e-11 42.2 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase HTH_Tnp_ISL3 PF13542.6 EMD61457.1 - 0.0065 15.9 0.0 0.041 13.3 0.0 2.3 2 0 0 2 2 2 1 Helix-turn-helix domain of transposase family ISL3 Kdo PF06293.14 EMD61457.1 - 0.037 13.4 0.1 0.096 12.0 0.0 1.7 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Sigma70_r4_2 PF08281.12 EMD61457.1 - 0.11 12.2 0.0 12 5.6 0.0 2.8 2 0 0 2 2 2 0 Sigma-70, region 4 Kinase-like PF14531.6 EMD61457.1 - 0.15 11.4 0.0 8.6 5.6 0.0 2.5 3 0 0 3 3 3 0 Kinase-like F-box PF00646.33 EMD61458.1 - 1.8e-11 43.6 0.0 5.9e-11 42.0 0.0 1.8 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EMD61458.1 - 1.8e-10 40.5 0.3 3.3e-10 39.7 0.3 1.5 1 0 0 1 1 1 1 F-box-like F-box_4 PF15966.5 EMD61458.1 - 0.026 14.4 0.0 0.051 13.5 0.0 1.5 1 0 0 1 1 1 0 F-box RNase_PH PF01138.21 EMD61459.1 - 6.7e-19 68.7 0.0 1.2e-18 67.9 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 MFS_1 PF07690.16 EMD61460.1 - 1.1e-12 47.5 25.3 1.1e-12 47.5 25.3 2.2 1 1 1 2 2 2 1 Major Facilitator Superfamily Nodulin-like PF06813.13 EMD61460.1 - 1.7e-07 31.0 7.1 1.7e-07 31.0 7.1 2.4 2 1 0 2 2 2 1 Nodulin-like 7tm_7 PF08395.12 EMD61460.1 - 0.0027 17.0 2.7 0.35 10.0 0.2 2.8 3 0 0 3 3 3 2 7tm Chemosensory receptor DUF4271 PF14093.6 EMD61460.1 - 0.15 11.9 3.9 0.74 9.7 0.6 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4271) Citrate_bind PF16114.5 EMD61461.1 - 2.8e-88 294.1 0.1 3.8e-88 293.6 0.1 1.2 1 0 0 1 1 1 1 ATP citrate lyase citrate-binding ATP-grasp_2 PF08442.10 EMD61461.1 - 3e-08 33.5 0.0 4.6e-08 32.9 0.0 1.2 1 0 0 1 1 1 1 ATP-grasp domain Citrate_synt PF00285.21 EMD61462.1 - 3.1e-20 72.6 0.0 1.1e-16 60.9 0.0 3.0 1 1 1 2 2 2 2 Citrate synthase, C-terminal domain CoA_binding PF02629.19 EMD61462.1 - 1.4e-17 64.2 0.0 3.5e-17 62.9 0.0 1.7 1 0 0 1 1 1 1 CoA binding domain Ligase_CoA PF00549.19 EMD61462.1 - 2.6e-14 53.3 0.3 4.6e-14 52.5 0.3 1.4 1 0 0 1 1 1 1 CoA-ligase Succ_CoA_lig PF13607.6 EMD61462.1 - 1.2e-06 28.4 0.0 1.6e-05 24.7 0.0 2.2 2 0 0 2 2 2 1 Succinyl-CoA ligase like flavodoxin domain His_Phos_2 PF00328.22 EMD61463.1 - 6.4e-14 52.1 0.6 8.4e-13 48.4 0.1 2.4 2 1 0 2 2 2 1 Histidine phosphatase superfamily (branch 2) Pilin_N PF07790.11 EMD61463.1 - 0.00049 21.0 0.4 0.0018 19.2 0.1 2.1 2 0 0 2 2 2 1 Archaeal Type IV pilin, N-terminal Granulin PF00396.18 EMD61464.1 - 5.5 7.4 20.5 6.5 7.2 12.6 3.0 2 1 0 2 2 2 0 Granulin Sod_Cu PF00080.20 EMD61465.1 - 1.2e-08 35.3 0.1 1.9e-08 34.6 0.1 1.3 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) CHRD PF07452.12 EMD61465.1 - 0.073 14.0 0.4 0.18 12.8 0.3 1.7 1 1 0 1 1 1 0 CHRD domain RRM_1 PF00076.22 EMD61466.1 - 3.7e-15 55.5 0.5 2.6e-08 33.6 0.1 3.0 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EMD61466.1 - 0.0062 16.6 0.0 0.012 15.7 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif TRAM_LAG1_CLN8 PF03798.16 EMD61467.1 - 1.8e-47 161.6 11.8 1.8e-47 161.6 11.8 1.6 2 0 0 2 2 2 1 TLC domain HIT PF01230.23 EMD61468.1 - 7.8e-18 65.0 0.1 1.4e-17 64.2 0.1 1.4 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 EMD61468.1 - 1.3e-05 25.6 0.0 3.2e-05 24.4 0.0 1.6 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.15 EMD61468.1 - 0.17 11.8 0.2 0.36 10.7 0.0 1.7 2 0 0 2 2 2 0 Protein similar to CwfJ C-terminus 1 Cyclin_N PF00134.23 EMD61470.1 - 4.4e-46 155.8 0.2 1.9e-44 150.5 0.2 2.3 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 EMD61470.1 - 6e-33 113.5 0.0 1.1e-32 112.6 0.0 1.4 1 0 0 1 1 1 1 Cyclin, C-terminal domain HEPN_Toprim_N PF18871.1 EMD61470.1 - 0.057 13.3 2.1 0.14 12.1 0.0 2.4 3 0 0 3 3 3 0 HEPN/Toprim N-terminal domain 1 Ribosomal_L2_C PF03947.18 EMD61471.1 - 3.1e-48 163.1 6.0 6.7e-48 162.1 3.7 2.5 3 0 0 3 3 3 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 EMD61471.1 - 6.7e-26 90.1 1.1 1.9e-25 88.6 1.1 1.8 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain Fungal_trans PF04082.18 EMD61472.1 - 1e-21 77.2 0.0 1.9e-21 76.3 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD61472.1 - 1.7e-08 34.4 11.3 1.7e-08 34.4 11.3 2.1 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain LIM PF00412.22 EMD61473.1 - 8.8e-27 93.1 28.0 3.4e-10 40.0 2.0 3.7 4 0 0 4 4 4 3 LIM domain CSN5_C PF18323.1 EMD61473.1 - 1.4 9.9 4.2 8.7 7.3 0.5 2.8 2 0 0 2 2 2 0 Cop9 signalosome subunit 5 C-terminal domain PHD PF00628.29 EMD61474.1 - 4.4e-09 36.1 10.5 1.1e-08 34.8 10.5 1.7 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 EMD61474.1 - 0.00014 21.4 3.3 0.00014 21.4 3.3 2.1 2 0 0 2 2 2 1 PHD-finger Zn-ribbon_8 PF09723.10 EMD61474.1 - 2.7 8.2 5.0 6.7 6.9 1.4 2.7 2 0 0 2 2 2 0 Zinc ribbon domain Ion_trans PF00520.31 EMD61475.1 - 1.9e-124 413.8 84.6 3.8e-41 140.9 5.4 4.9 4 1 0 4 4 4 4 Ion transport protein GPHH PF16905.5 EMD61475.1 - 0.00036 20.2 0.0 0.00089 19.0 0.0 1.7 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated EF-hand_1 PF00036.32 EMD61475.1 - 0.0083 15.6 0.0 0.025 14.1 0.0 1.8 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 EMD61475.1 - 0.046 13.7 0.0 0.2 11.7 0.0 2.2 1 0 0 1 1 1 0 EF-hand domain EF-hand_7 PF13499.6 EMD61475.1 - 0.11 12.9 0.0 0.36 11.3 0.0 1.9 1 0 0 1 1 1 0 EF-hand domain pair Cpta_toxin PF07254.12 EMD61476.1 - 0.14 12.2 0.8 0.25 11.3 0.2 1.6 2 0 0 2 2 2 0 Membrane-bound toxin component of toxin-antitoxin system QWRF PF04484.12 EMD61477.1 - 0.18 11.5 5.7 0.21 11.3 5.7 1.1 1 0 0 1 1 1 0 QWRF family Myb_Cef PF11831.8 EMD61478.1 - 2.4e-49 168.0 8.9 2.4e-49 168.0 8.9 3.5 3 0 0 3 3 3 1 pre-mRNA splicing factor component Myb_DNA-binding PF00249.31 EMD61478.1 - 3.3e-18 65.6 5.6 2.4e-10 40.5 2.0 2.9 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EMD61478.1 - 2.3e-14 53.4 4.6 2.2e-09 37.4 3.8 2.6 1 1 1 2 2 2 2 Myb-like DNA-binding domain TORC_M PF12885.7 EMD61478.1 - 0.029 14.3 0.0 2.1 8.2 0.0 2.9 2 0 0 2 2 2 0 Transducer of regulated CREB activity middle domain HTH_AsnC-type PF13404.6 EMD61478.1 - 0.11 12.4 2.0 0.91 9.4 0.0 2.8 2 0 0 2 2 2 0 AsnC-type helix-turn-helix domain DUF1053 PF06327.14 EMD61479.1 - 0.014 16.0 0.0 0.019 15.5 0.0 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1053) DUF515 PF04415.12 EMD61479.1 - 0.056 11.8 0.3 0.059 11.7 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF515) OB_NTP_bind PF07717.16 EMD61481.1 - 3.5e-23 81.8 0.0 1.1e-22 80.2 0.0 1.9 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.23 EMD61481.1 - 1.9e-18 66.7 0.0 4.4e-18 65.5 0.0 1.7 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 EMD61481.1 - 1.8e-10 41.2 0.0 5.6e-10 39.6 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EMD61481.1 - 5.3e-07 29.6 0.2 1.2e-06 28.4 0.2 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EMD61481.1 - 2e-06 28.1 0.0 8e-06 26.2 0.0 2.0 1 0 0 1 1 1 1 AAA domain SRP54 PF00448.22 EMD61481.1 - 0.00029 20.5 0.1 0.00089 18.9 0.1 1.8 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_30 PF13604.6 EMD61481.1 - 0.011 15.5 0.0 0.019 14.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain Flavi_DEAD PF07652.14 EMD61481.1 - 0.013 15.4 0.6 0.028 14.4 0.1 1.8 2 0 0 2 2 2 0 Flavivirus DEAD domain T2SSE PF00437.20 EMD61481.1 - 0.022 13.8 0.0 0.044 12.8 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_23 PF13476.6 EMD61481.1 - 0.025 15.1 0.0 0.084 13.4 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 EMD61481.1 - 0.04 13.4 0.0 0.094 12.2 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region PRMT5_TIM PF17285.2 EMD61482.1 - 1.9e-72 243.5 0.0 2.5e-72 243.1 0.0 1.2 1 0 0 1 1 1 1 PRMT5 TIM barrel domain PRMT5 PF05185.16 EMD61482.1 - 1e-70 237.1 0.0 1.5e-70 236.5 0.0 1.3 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase PRMT5_C PF17286.2 EMD61482.1 - 3.3e-58 196.5 0.0 6.8e-58 195.4 0.0 1.6 1 0 0 1 1 1 1 PRMT5 oligomerisation domain Met_10 PF02475.16 EMD61482.1 - 0.049 13.4 0.0 0.077 12.7 0.0 1.2 1 0 0 1 1 1 0 Met-10+ like-protein MSA-2c PF12238.8 EMD61482.1 - 0.14 12.2 1.0 0.23 11.4 1.0 1.3 1 0 0 1 1 1 0 Merozoite surface antigen 2c Brix PF04427.18 EMD61483.1 - 6.1e-31 108.0 0.0 7.7e-31 107.7 0.0 1.1 1 0 0 1 1 1 1 Brix domain ORC6 PF05460.13 EMD61487.1 - 1.1e-37 130.1 7.9 2.7e-36 125.6 7.9 2.2 1 1 0 1 1 1 1 Origin recognition complex subunit 6 (ORC6) p450 PF00067.22 EMD61489.1 - 2.7e-57 194.6 0.0 3.4e-57 194.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Rpn3_C PF08375.11 EMD61489.1 - 0.17 12.3 0.2 0.37 11.2 0.2 1.5 1 0 0 1 1 1 0 Proteasome regulatory subunit C-terminal UNC45-central PF11701.8 EMD61490.1 - 1.4e-42 145.2 3.6 1.4e-42 145.2 3.6 3.0 4 0 0 4 4 4 1 Myosin-binding striated muscle assembly central IBN_N PF03810.19 EMD61490.1 - 0.022 14.7 0.0 0.097 12.6 0.0 2.1 1 0 0 1 1 1 0 Importin-beta N-terminal domain NPA PF16469.5 EMD61490.1 - 0.028 15.0 3.1 1.7 9.2 0.1 2.5 2 0 0 2 2 2 0 Nematode polyprotein allergen ABA-1 TetR_C_28 PF17937.1 EMD61490.1 - 0.037 14.5 1.9 0.18 12.3 0.1 3.0 3 0 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain Dicer_dimer PF03368.14 EMD61490.1 - 0.04 14.1 0.0 0.18 12.0 0.0 2.1 2 0 0 2 2 2 0 Dicer dimerisation domain HEAT_2 PF13646.6 EMD61490.1 - 0.21 12.0 9.7 0.27 11.6 0.3 5.1 4 1 3 7 7 7 0 HEAT repeats LRR_4 PF12799.7 EMD61491.1 - 2.2e-18 66.1 46.3 3.6e-06 27.2 0.7 9.1 6 2 3 9 9 9 7 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EMD61491.1 - 2.2e-15 56.2 44.5 0.00034 20.3 3.8 6.9 3 2 3 7 7 7 7 Leucine rich repeat LRR_9 PF14580.6 EMD61491.1 - 4.2e-11 42.6 21.6 0.005 16.4 1.2 4.8 3 1 1 5 5 5 4 Leucine-rich repeat LRR_6 PF13516.6 EMD61491.1 - 2.4 8.4 21.9 24 5.3 0.0 7.6 7 0 0 7 7 7 0 Leucine Rich repeat LRR_1 PF00560.33 EMD61491.1 - 2.7 8.9 28.3 15 6.7 0.1 9.1 8 2 0 8 8 8 0 Leucine Rich Repeat DUF4637 PF15470.6 EMD61492.1 - 0.027 14.2 6.5 0.11 12.2 6.5 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) FAM176 PF14851.6 EMD61492.1 - 1.6 8.4 6.2 6.7 6.4 6.2 2.1 1 0 0 1 1 1 0 FAM176 family IPK PF03770.16 EMD61493.1 - 9.6e-58 195.3 0.0 2.1e-57 194.2 0.0 1.6 1 0 0 1 1 1 1 Inositol polyphosphate kinase DHO_dh PF01180.21 EMD61494.1 - 5.4e-16 58.6 0.1 2e-13 50.2 0.1 2.1 1 1 0 1 1 1 1 Dihydroorotate dehydrogenase EHN PF06441.12 EMD61496.1 - 5.6e-36 123.2 2.1 3.3e-35 120.7 0.1 2.3 2 0 0 2 2 2 1 Epoxide hydrolase N terminus Abhydrolase_1 PF00561.20 EMD61496.1 - 4.4e-09 36.4 0.1 7.7e-09 35.6 0.1 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EMD61496.1 - 0.0072 17.0 8.6 0.08 13.5 8.6 2.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Aminotran_3 PF00202.21 EMD61497.1 - 4.9e-35 121.0 0.2 3.2e-26 91.9 0.0 2.0 1 1 1 2 2 2 2 Aminotransferase class-III Aminotran_5 PF00266.19 EMD61497.1 - 0.014 14.3 0.0 0.07 12.1 0.0 1.9 1 1 0 1 1 1 0 Aminotransferase class-V MMgT PF10270.9 EMD61499.1 - 2.1e-29 101.8 0.0 2.5e-29 101.6 0.0 1.1 1 0 0 1 1 1 1 Membrane magnesium transporter Ntox17 PF15524.6 EMD61499.1 - 0.11 12.8 0.4 0.18 12.1 0.0 1.5 2 0 0 2 2 2 0 Novel toxin 17 FAD_binding_3 PF01494.19 EMD61500.1 - 8.7e-10 38.4 0.0 1.2e-09 37.9 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Glyco_hydro_35 PF01301.19 EMD61501.1 - 2.7e-92 309.8 0.3 6.3e-92 308.6 0.0 1.7 2 0 0 2 2 2 1 Glycosyl hydrolases family 35 BetaGal_dom4_5 PF13364.6 EMD61501.1 - 1.9e-56 189.5 9.8 3e-31 108.3 0.0 3.1 3 0 0 3 3 3 2 Beta-galactosidase jelly roll domain BetaGal_dom2 PF10435.9 EMD61501.1 - 1.9e-55 187.5 3.5 4.3e-55 186.3 3.5 1.6 1 0 0 1 1 1 1 Beta-galactosidase, domain 2 BetaGal_dom3 PF13363.6 EMD61501.1 - 1.3e-21 75.9 0.3 1.7e-20 72.4 0.1 2.6 2 0 0 2 2 2 1 Beta-galactosidase, domain 3 fn3 PF00041.21 EMD61501.1 - 0.09 13.1 0.1 0.41 11.0 0.0 2.3 2 0 0 2 2 2 0 Fibronectin type III domain DUF4115 PF13464.6 EMD61501.1 - 0.1 12.8 0.1 1.6 8.9 0.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4115) Fungal_trans PF04082.18 EMD61503.1 - 2.1e-14 53.2 0.0 3.9e-14 52.3 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD61503.1 - 0.04 14.1 11.7 0.077 13.1 11.7 1.4 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain adh_short PF00106.25 EMD61505.1 - 2.6e-22 79.2 0.0 3e-22 79.0 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD61505.1 - 1.2e-20 74.1 0.0 1.5e-20 73.7 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD61505.1 - 0.00082 19.3 0.0 0.0012 18.8 0.0 1.5 1 1 0 1 1 1 1 KR domain DUF460 PF04312.13 EMD61505.1 - 0.0064 16.2 0.2 0.011 15.4 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF460) MlaE PF02405.16 EMD61505.1 - 0.1 12.2 0.1 0.19 11.4 0.1 1.3 1 0 0 1 1 1 0 Permease MlaE CHORD PF04968.12 EMD61506.1 - 9.4e-50 167.2 21.9 2e-25 89.3 6.4 2.3 2 0 0 2 2 2 2 CHORD CS PF04969.16 EMD61506.1 - 7e-14 52.6 0.2 1e-13 52.1 0.2 1.3 1 0 0 1 1 1 1 CS domain BTK PF00779.19 EMD61506.1 - 1.9 8.4 12.4 7.4 6.5 1.0 3.4 2 1 0 2 2 2 0 BTK motif DUF836 PF05768.14 EMD61507.1 - 1.3e-12 47.9 0.0 1.5e-12 47.8 0.0 1.1 1 0 0 1 1 1 1 Glutaredoxin-like domain (DUF836) Glutaredoxin PF00462.24 EMD61507.1 - 0.009 16.2 0.0 0.014 15.6 0.0 1.4 1 0 0 1 1 1 1 Glutaredoxin RicinB_lectin_2 PF14200.6 EMD61508.1 - 0.00037 21.2 0.0 0.15 12.8 0.0 2.3 1 1 1 2 2 2 2 Ricin-type beta-trefoil lectin domain-like HpcH_HpaI PF03328.14 EMD61509.1 - 3.7e-27 94.9 0.0 4.8e-27 94.5 0.0 1.1 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family DSPc PF00782.20 EMD61509.1 - 0.012 15.4 0.0 0.023 14.5 0.0 1.4 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain IGPS PF00218.21 EMD61509.1 - 0.087 12.0 0.1 0.28 10.3 0.0 1.8 2 0 0 2 2 2 0 Indole-3-glycerol phosphate synthase DUF2156 PF09924.9 EMD61509.1 - 0.22 10.5 0.0 0.32 10.0 0.0 1.1 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2156) Asparaginase_2 PF01112.18 EMD61510.1 - 5.4e-48 163.6 4.0 2.5e-31 108.9 0.0 2.2 2 0 0 2 2 2 2 Asparaginase Actin PF00022.19 EMD61511.1 - 9.3e-88 294.6 0.0 8.1e-53 179.5 0.0 2.0 1 1 1 2 2 2 2 Actin MreB_Mbl PF06723.13 EMD61511.1 - 7.6e-05 21.7 0.0 0.0089 14.9 0.0 2.5 2 1 0 2 2 2 2 MreB/Mbl protein FtsA PF14450.6 EMD61511.1 - 0.00083 19.7 0.0 0.0013 19.1 0.0 1.4 1 0 0 1 1 1 1 Cell division protein FtsA DUF829 PF05705.14 EMD61511.1 - 0.18 11.7 0.0 0.4 10.5 0.0 1.5 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF829) tRNA_U5-meth_tr PF05958.11 EMD61512.1 - 8.1e-14 51.4 0.0 9.2e-13 47.9 0.0 2.6 2 1 0 2 2 2 1 tRNA (Uracil-5-)-methyltransferase Methyltransf_15 PF09445.10 EMD61512.1 - 3.6e-05 23.4 0.0 7.2e-05 22.4 0.0 1.5 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_25 PF13649.6 EMD61512.1 - 0.00069 20.3 0.0 0.0016 19.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 EMD61512.1 - 0.0023 17.6 0.0 0.0042 16.7 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_31 PF13847.6 EMD61512.1 - 0.0034 17.2 0.0 0.0065 16.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain TRM PF02005.16 EMD61512.1 - 0.0079 15.4 0.2 0.076 12.2 0.0 2.0 2 0 0 2 2 2 1 N2,N2-dimethylguanosine tRNA methyltransferase PrmA PF06325.13 EMD61512.1 - 0.011 15.2 0.0 0.017 14.5 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_11 PF08241.12 EMD61512.1 - 0.029 15.0 0.0 0.068 13.8 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.14 EMD61512.1 - 0.16 11.5 0.0 0.27 10.8 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Ribosomal_S5_C PF03719.15 EMD61513.1 - 1.1e-22 79.2 0.0 2.3e-22 78.2 0.0 1.6 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain Ribosomal_S5 PF00333.20 EMD61513.1 - 1.1e-16 60.5 0.1 3.1e-16 59.1 0.1 1.8 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain DUF5615 PF18480.1 EMD61513.1 - 0.14 11.9 0.0 0.3 10.8 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5615) DASH_Dad3 PF08656.10 EMD61514.1 - 2.8e-29 101.0 1.3 3.5e-29 100.7 1.3 1.0 1 0 0 1 1 1 1 DASH complex subunit Dad3 Pkinase PF00069.25 EMD61515.1 - 1.8e-72 243.9 0.0 2.5e-72 243.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD61515.1 - 6.3e-31 107.6 0.0 2.7e-22 79.3 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EMD61515.1 - 2.8e-06 26.9 0.1 0.4 10.0 0.0 3.1 3 0 0 3 3 3 3 Kinase-like Pkinase_fungal PF17667.1 EMD61515.1 - 0.009 14.8 0.0 0.017 13.9 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EMD61515.1 - 0.015 14.7 0.0 0.025 13.9 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EMD61515.1 - 0.09 12.7 0.0 1.4 8.7 0.1 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family PQQ_2 PF13360.6 EMD61516.1 - 0.053 13.1 0.0 0.053 13.1 0.0 1.0 1 0 0 1 1 1 0 PQQ-like domain YojJ PF10372.9 EMD61517.1 - 0.35 11.0 1.0 0.82 9.8 1.0 1.6 1 0 0 1 1 1 0 Bacterial membrane-spanning protein N-terminus Mre11_DNA_bind PF04152.14 EMD61518.1 - 9.8e-52 175.7 2.6 9.8e-52 175.7 2.6 2.3 3 0 0 3 3 3 1 Mre11 DNA-binding presumed domain Metallophos PF00149.28 EMD61518.1 - 1.5e-16 61.5 2.1 2.6e-16 60.7 2.1 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EMD61518.1 - 1.2e-06 28.9 0.6 6.3e-06 26.5 0.6 2.3 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain RhoGAP PF00620.27 EMD61518.1 - 0.05 13.4 2.5 1.3 8.8 0.8 2.4 2 0 0 2 2 2 0 RhoGAP domain MSP1_C PF07462.11 EMD61518.1 - 6.2 5.4 12.9 0.2 10.3 3.5 2.2 2 0 0 2 2 2 0 Merozoite surface protein 1 (MSP1) C-terminus RecG_N PF17190.4 EMD61518.1 - 7 7.5 8.3 0.23 12.2 0.6 2.5 3 0 0 3 3 3 0 RecG N-terminal helical domain Ribosomal_S19 PF00203.21 EMD61519.1 - 1.8e-27 95.0 0.0 2.1e-27 94.8 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S19 TFIID_30kDa PF03540.13 EMD61520.1 - 6.7e-23 80.4 0.2 1.2e-22 79.6 0.2 1.5 1 0 0 1 1 1 1 Transcription initiation factor TFIID 23-30kDa subunit La PF05383.17 EMD61522.1 - 2.1e-18 66.1 0.1 3.9e-18 65.2 0.1 1.5 1 0 0 1 1 1 1 La domain MFS_1 PF07690.16 EMD61524.1 - 1.5e-25 89.9 45.8 2e-14 53.3 23.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EMD61524.1 - 0.0038 15.8 23.6 0.046 12.3 10.3 2.2 1 1 1 2 2 2 2 MFS/sugar transport protein PAM2 PF07145.15 EMD61525.1 - 1.7 8.5 20.0 0.19 11.5 0.6 5.1 4 1 1 5 5 5 0 Ataxin-2 C-terminal region SET PF00856.28 EMD61526.1 - 6.3e-21 75.5 0.3 1.7e-20 74.1 0.2 1.9 2 0 0 2 2 2 1 SET domain Pre-SET PF05033.16 EMD61526.1 - 1.7e-16 60.8 3.9 1.7e-16 60.8 3.9 2.2 2 1 0 2 2 2 1 Pre-SET motif Chromo PF00385.24 EMD61526.1 - 0.0011 18.8 0.3 0.0024 17.8 0.3 1.5 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Kre28 PF17097.5 EMD61526.1 - 0.22 10.4 0.7 0.31 9.9 0.7 1.1 1 0 0 1 1 1 0 Spindle pole body component Nop52 PF05997.12 EMD61527.1 - 5e-72 242.2 2.5 5.8e-72 242.0 2.5 1.0 1 0 0 1 1 1 1 Nucleolar protein,Nop52 TAN PF11640.8 EMD61527.1 - 0.00033 20.8 0.1 0.0012 19.1 0.1 1.8 1 1 0 1 1 1 1 Telomere-length maintenance and DNA damage repair Qua1 PF16274.5 EMD61527.1 - 0.053 13.4 0.8 0.11 12.3 0.8 1.5 1 0 0 1 1 1 0 Qua1 domain HEAT PF02985.22 EMD61527.1 - 0.11 12.8 0.0 0.41 11.0 0.0 1.9 1 0 0 1 1 1 0 HEAT repeat RasGEF_N_2 PF14663.6 EMD61527.1 - 0.13 12.6 2.1 3.8 8.0 0.0 2.5 2 1 0 2 2 2 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain Zn_clus PF00172.18 EMD61529.1 - 0.0083 16.2 7.8 0.021 14.9 7.8 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-BED PF02892.15 EMD61529.1 - 0.069 13.2 0.1 0.069 13.2 0.1 2.2 2 0 0 2 2 2 0 BED zinc finger Snf7 PF03357.21 EMD61530.1 - 2.7e-25 88.9 17.4 2.7e-25 88.9 17.4 1.6 1 1 1 2 2 2 1 Snf7 GAS PF13851.6 EMD61530.1 - 0.0094 15.3 9.9 0.0094 15.3 9.9 2.2 2 1 0 2 2 2 1 Growth-arrest specific micro-tubule binding 7TMR-HDED PF07697.11 EMD61530.1 - 0.081 13.0 11.4 0.14 12.3 11.3 1.4 1 1 0 1 1 1 0 7TM-HD extracellular MerR-DNA-bind PF09278.11 EMD61530.1 - 1.4 9.5 11.4 0.57 10.8 0.3 3.5 3 0 0 3 3 3 0 MerR, DNA binding FapA PF03961.13 EMD61530.1 - 1.8 7.1 11.6 1.1 7.8 7.7 2.0 1 1 0 2 2 2 0 Flagellar Assembly Protein A Allexi_40kDa PF05549.11 EMD61530.1 - 4.6 6.7 9.0 2.4 7.6 5.2 2.0 1 1 1 2 2 2 0 Allexivirus 40kDa protein YlqD PF11068.8 EMD61530.1 - 5.5 7.4 22.8 1.9 8.9 14.8 2.5 2 1 0 2 2 2 0 YlqD protein L31 PF09784.9 EMD61530.1 - 7 7.1 9.2 1.7 9.1 4.4 2.2 2 1 1 3 3 3 0 Mitochondrial ribosomal protein L31 CRR7 PF12095.8 EMD61530.1 - 8.2 7.0 9.5 0.61 10.6 0.7 3.0 3 1 0 3 3 3 0 Protein CHLORORESPIRATORY REDUCTION 7 Fib_alpha PF08702.10 EMD61530.1 - 8.9 6.5 12.3 8.5 6.6 10.2 1.9 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family CS PF04969.16 EMD61531.1 - 4.8e-08 33.9 0.0 7e-08 33.4 0.0 1.2 1 0 0 1 1 1 1 CS domain DUF5091 PF17012.5 EMD61531.1 - 0.071 13.4 0.1 0.15 12.3 0.0 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF5091) HAD_2 PF13419.6 EMD61532.1 - 4.3e-21 75.8 0.0 7.3e-21 75.1 0.0 1.4 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EMD61532.1 - 9.6e-12 45.6 0.0 3.2e-10 40.6 0.0 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 EMD61532.1 - 9.4e-05 22.9 0.1 0.00025 21.5 0.0 1.8 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 EMD61532.1 - 0.00036 20.6 0.0 0.0058 16.7 0.0 2.3 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EMD61532.1 - 0.0012 18.9 0.0 0.0049 16.9 0.0 1.9 2 0 0 2 2 2 1 HAD-hyrolase-like NT5C PF06941.12 EMD61532.1 - 0.0085 16.0 0.0 0.053 13.4 0.0 2.0 1 1 0 1 1 1 1 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) TPR_1 PF00515.28 EMD61533.1 - 1.5e-08 34.1 1.7 0.005 16.6 0.1 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 EMD61533.1 - 1.4e-06 28.4 2.0 4.1e-06 27.0 2.0 1.8 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.17 EMD61533.1 - 9.1e-06 25.4 4.0 0.085 13.0 0.2 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 EMD61533.1 - 0.00012 21.8 0.0 0.027 14.5 0.0 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 EMD61533.1 - 0.0003 20.4 0.4 0.0003 20.4 0.4 2.4 3 0 0 3 3 3 1 TPR repeat TPR_19 PF14559.6 EMD61533.1 - 0.0018 18.7 2.9 0.0099 16.4 0.1 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat SLATT_5 PF18160.1 EMD61533.1 - 0.019 14.3 0.1 0.061 12.6 0.0 1.7 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain family 5 CAMSAP_CC1 PF17095.5 EMD61533.1 - 0.023 14.6 0.3 0.3 11.0 0.0 2.4 2 0 0 2 2 2 0 Spectrin-binding region of Ca2+-Calmodulin TPR_8 PF13181.6 EMD61533.1 - 0.076 13.3 0.6 7.3 7.1 0.0 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 EMD61533.1 - 0.4 11.6 3.0 3.7 8.6 0.0 3.3 3 1 1 4 4 4 0 Tetratricopeptide repeat p450 PF00067.22 EMD61535.1 - 5.8e-23 81.4 0.0 6.7e-23 81.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 RNA_pol_Rpb5_C PF01191.19 EMD61535.1 - 0.0069 16.2 0.0 0.014 15.3 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb5, C-terminal domain UPF0020 PF01170.18 EMD61536.1 - 5.1e-09 36.1 0.1 3e-06 27.1 0.1 2.8 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 Lipase_GDSL_2 PF13472.6 EMD61537.1 - 1.3e-11 45.2 2.3 1.6e-11 44.9 2.3 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Rhomboid PF01694.22 EMD61538.1 - 8.2e-18 64.8 6.5 8.2e-18 64.8 6.5 1.6 2 0 0 2 2 2 1 Rhomboid family CPBP PF02517.16 EMD61538.1 - 0.084 13.2 1.9 1.5 9.2 0.2 2.3 2 0 0 2 2 2 0 CPBP intramembrane metalloprotease DUF2956 PF11169.8 EMD61538.1 - 0.11 12.7 0.0 0.11 12.7 0.0 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2956) CrgA PF06781.12 EMD61538.1 - 0.16 12.1 0.5 0.85 9.7 0.0 2.5 2 0 0 2 2 2 0 Cell division protein CrgA MAP7 PF05672.11 EMD61538.1 - 0.16 11.6 23.2 0.32 10.7 23.2 1.4 1 0 0 1 1 1 0 MAP7 (E-MAP-115) family PI-PLC-X PF00388.19 EMD61539.1 - 3.8e-09 36.3 0.0 6.8e-09 35.5 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain SIR2 PF02146.17 EMD61540.1 - 1.1e-26 93.8 0.0 3.5e-26 92.2 0.0 1.8 1 1 0 1 1 1 1 Sir2 family Red1 PF07964.11 EMD61540.1 - 6.8 4.8 7.4 11 4.1 7.4 1.4 1 0 0 1 1 1 0 Rec10 / Red1 Med16 PF11635.8 EMD61541.1 - 1.3e-170 569.0 0.0 1.5e-170 568.7 0.0 1.0 1 0 0 1 1 1 1 Mediator complex subunit 16 YchF-GTPase_C PF06071.13 EMD61542.1 - 1.2e-33 115.2 0.2 3.4e-33 113.7 0.2 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.23 EMD61542.1 - 3.6e-16 59.3 0.0 9.4e-16 57.9 0.0 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EMD61542.1 - 0.00052 19.6 0.0 0.0017 17.9 0.0 1.9 2 1 0 2 2 2 1 Ferrous iron transport protein B TGS PF02824.21 EMD61542.1 - 0.0013 18.8 0.0 0.0027 17.7 0.0 1.5 1 0 0 1 1 1 1 TGS domain Dynamin_N PF00350.23 EMD61542.1 - 0.034 14.2 0.0 0.75 9.8 0.0 2.6 2 1 1 3 3 3 0 Dynamin family AAA_23 PF13476.6 EMD61542.1 - 3.8 8.0 6.7 39 4.6 6.7 2.5 1 1 0 1 1 1 0 AAA domain Peptidase_C97 PF05903.14 EMD61543.1 - 3.1e-32 111.5 0.0 4e-32 111.2 0.0 1.1 1 0 0 1 1 1 1 PPPDE putative peptidase domain LRAT PF04970.13 EMD61543.1 - 0.00031 21.1 0.2 0.00067 20.0 0.0 1.6 2 0 0 2 2 2 1 Lecithin retinol acyltransferase RhlB PF12300.8 EMD61543.1 - 0.0032 17.6 1.4 0.0051 17.0 1.4 1.3 1 0 0 1 1 1 1 ATP-dependent RNA helicase RhlB DUF778 PF05608.12 EMD61543.1 - 0.016 15.6 0.0 0.033 14.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF778) Ribosomal_S11 PF00411.19 EMD61544.1 - 1.5e-07 31.8 0.0 2.7e-07 31.0 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S11 Tim44 PF04280.15 EMD61545.1 - 5.6e-36 123.9 0.0 9.6e-36 123.1 0.0 1.4 1 0 0 1 1 1 1 Tim44-like domain Med7 PF05983.11 EMD61545.1 - 0.83 9.7 5.7 1.7 8.7 5.7 1.5 1 0 0 1 1 1 0 MED7 protein NPR3 PF03666.13 EMD61545.1 - 0.96 8.2 5.8 4.7 5.9 6.6 1.7 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 CDC45 PF02724.14 EMD61545.1 - 4.4 5.5 8.7 6.7 4.9 8.7 1.2 1 0 0 1 1 1 0 CDC45-like protein 4HBT PF03061.22 EMD61546.1 - 5.5e-11 42.7 0.0 9.3e-11 41.9 0.0 1.4 1 0 0 1 1 1 1 Thioesterase superfamily FAD_binding_3 PF01494.19 EMD61547.1 - 5.2e-76 256.2 0.0 6.5e-76 255.8 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Phe_hydrox_dim PF07976.12 EMD61547.1 - 1.9e-36 125.6 0.0 3.1e-36 124.9 0.0 1.3 1 0 0 1 1 1 1 Phenol hydroxylase, C-terminal dimerisation domain DAO PF01266.24 EMD61547.1 - 1.9e-06 27.7 0.2 0.0017 18.0 0.1 2.3 1 1 1 2 2 2 2 FAD dependent oxidoreductase Pyr_redox PF00070.27 EMD61547.1 - 0.0017 18.8 0.0 0.0069 16.9 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EMD61547.1 - 0.0022 18.2 0.0 0.0051 17.0 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EMD61547.1 - 0.0029 16.9 0.0 0.013 14.7 0.0 2.0 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase UDPG_MGDP_dh_N PF03721.14 EMD61547.1 - 0.019 14.6 0.0 0.035 13.7 0.0 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Thi4 PF01946.17 EMD61547.1 - 0.029 13.6 0.0 0.047 12.9 0.0 1.3 1 0 0 1 1 1 0 Thi4 family ApbA PF02558.16 EMD61547.1 - 0.055 13.1 0.0 0.1 12.2 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Lycopene_cycl PF05834.12 EMD61547.1 - 0.062 12.3 0.0 0.11 11.5 0.0 1.4 1 0 0 1 1 1 0 Lycopene cyclase protein XdhC_C PF13478.6 EMD61547.1 - 0.076 13.5 0.0 0.15 12.5 0.0 1.5 1 0 0 1 1 1 0 XdhC Rossmann domain DFRP_C PF16543.5 EMD61549.1 - 5.9e-27 94.0 8.7 5.9e-27 94.0 8.7 3.6 3 0 0 3 3 3 1 DRG Family Regulatory Proteins, Tma46 zf-CCCH PF00642.24 EMD61549.1 - 2.4e-06 27.3 2.1 2.4e-06 27.3 2.1 2.7 3 1 0 3 3 3 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 EMD61549.1 - 2.6e-06 27.1 13.3 7.5e-05 22.4 2.6 3.4 3 0 0 3 3 3 2 CCCH-type zinc finger Torus PF16131.5 EMD61549.1 - 2.8e-05 24.7 4.1 2.8e-05 24.7 4.1 3.9 2 2 2 4 4 4 2 Torus domain zf_CCCH_4 PF18345.1 EMD61549.1 - 0.00012 22.1 8.4 0.00012 22.1 8.4 3.4 4 0 0 4 4 4 1 Zinc finger domain zf-CCCH_3 PF15663.5 EMD61549.1 - 0.0023 18.1 1.2 0.19 12.0 0.2 2.6 2 0 0 2 2 2 1 Zinc-finger containing family zf-CCCH_2 PF14608.6 EMD61549.1 - 0.058 13.9 5.4 0.058 13.9 5.4 2.9 2 1 0 2 2 2 0 RNA-binding, Nab2-type zinc finger CENP-B_dimeris PF09026.10 EMD61549.1 - 8.7 6.8 10.8 18 5.8 1.4 2.5 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Ost4 PF10215.9 EMD61550.1 - 5.8e-20 70.8 1.8 6.7e-20 70.6 1.8 1.1 1 0 0 1 1 1 1 Oligosaccaryltransferase Selenoprotein_S PF06936.11 EMD61551.1 - 0.07 12.9 8.6 0.095 12.5 5.8 2.5 2 0 0 2 2 2 0 Selenoprotein S (SelS) LD_cluster2 PF18163.1 EMD61551.1 - 0.17 11.4 1.5 0.62 9.6 1.4 2.0 1 1 0 1 1 1 0 SLOG cluster2 Ribosomal_L26 PF16906.5 EMD61552.1 - 1.3e-38 131.3 2.5 1.7e-38 130.9 2.5 1.2 1 0 0 1 1 1 1 Ribosomal proteins L26 eukaryotic, L24P archaeal KOW PF00467.29 EMD61552.1 - 2.7e-05 24.0 0.7 5.3e-05 23.0 0.7 1.5 1 0 0 1 1 1 1 KOW motif Kelch_5 PF13854.6 EMD61553.1 - 0.0013 18.6 0.2 0.45 10.6 0.0 3.4 3 0 0 3 3 3 1 Kelch motif RIFIN PF02009.16 EMD61553.1 - 0.0053 16.7 0.0 0.008 16.1 0.0 1.2 1 0 0 1 1 1 1 Rifin DcuC PF03606.15 EMD61553.1 - 0.06 11.8 0.2 0.089 11.2 0.2 1.1 1 0 0 1 1 1 0 C4-dicarboxylate anaerobic carrier Kelch_6 PF13964.6 EMD61553.1 - 1.7 9.0 5.4 26 5.3 0.0 4.4 5 0 0 5 5 5 0 Kelch motif G-patch PF01585.23 EMD61555.1 - 0.00072 19.4 0.2 0.0015 18.4 0.2 1.6 1 0 0 1 1 1 1 G-patch domain adh_short PF00106.25 EMD61556.1 - 8.1e-16 58.1 0.0 2.1e-11 43.7 0.0 2.3 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EMD61556.1 - 4.9e-06 26.3 0.0 0.00025 20.7 0.0 2.2 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD61556.1 - 3.1e-05 23.9 0.0 5.4e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EMD61556.1 - 0.00072 19.1 0.0 0.0015 18.1 0.0 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 EMD61556.1 - 0.0057 16.2 0.0 0.0096 15.5 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family SAM_MT PF04445.13 EMD61556.1 - 0.064 12.7 0.0 0.13 11.7 0.0 1.4 1 0 0 1 1 1 0 Putative SAM-dependent methyltransferase Neisseria_TspB PF05616.13 EMD61557.1 - 9.3 4.6 6.9 12 4.2 6.9 1.1 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein Pyr_redox_2 PF07992.14 EMD61558.1 - 9.8e-15 54.5 0.3 1.6e-13 50.6 0.3 2.1 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EMD61558.1 - 1.9e-05 24.1 0.0 0.0024 17.2 0.0 2.2 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EMD61558.1 - 0.00034 19.4 0.0 0.0009 18.0 0.0 1.7 2 0 0 2 2 2 1 HI0933-like protein FAD_binding_2 PF00890.24 EMD61558.1 - 0.00043 19.5 2.9 0.00056 19.1 0.0 2.3 2 1 0 2 2 2 1 FAD binding domain GIDA PF01134.22 EMD61558.1 - 0.0021 17.2 1.2 0.088 11.9 0.1 2.6 2 1 1 3 3 3 1 Glucose inhibited division protein A FAD_oxidored PF12831.7 EMD61558.1 - 0.017 14.5 0.3 0.034 13.5 0.2 1.6 1 1 0 1 1 1 0 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EMD61558.1 - 0.019 15.2 0.0 0.058 13.6 0.0 1.9 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EMD61558.1 - 0.051 13.2 0.4 0.13 11.8 0.4 1.9 1 1 0 1 1 1 0 FAD dependent oxidoreductase ApbA_C PF08546.11 EMD61558.1 - 0.053 13.7 1.6 9.8 6.4 0.5 2.4 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA C terminal MFS_1 PF07690.16 EMD61559.1 - 2.7e-24 85.8 45.8 6.2e-19 68.1 24.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Ferritin_2 PF13668.6 EMD61560.1 - 3e-40 137.5 2.8 4.5e-40 137.0 2.8 1.3 1 0 0 1 1 1 1 Ferritin-like domain RNB PF00773.19 EMD61561.1 - 2.5e-88 296.6 0.0 4.4e-88 295.8 0.0 1.4 1 0 0 1 1 1 1 RNB domain OB_Dis3 PF17849.1 EMD61561.1 - 1.5e-25 89.0 0.0 4.4e-25 87.5 0.0 1.9 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) Dis3l2_C_term PF17877.1 EMD61561.1 - 7.2e-25 87.1 0.0 2.7e-24 85.3 0.0 2.1 1 0 0 1 1 1 1 DIS3-like exonuclease 2 C terminal CSD2 PF17876.1 EMD61561.1 - 0.00029 21.0 0.0 0.12 12.5 0.0 2.7 2 0 0 2 2 2 2 Cold shock domain Rrp44_CSD1 PF17216.3 EMD61561.1 - 0.0016 18.2 0.8 0.006 16.3 0.0 2.1 2 0 0 2 2 2 1 Rrp44-like cold shock domain GLE1 PF07817.13 EMD61562.1 - 2.4e-29 102.3 0.0 4.1e-29 101.5 0.0 1.4 1 0 0 1 1 1 1 GLE1-like protein PTCB-BRCT PF12738.7 EMD61564.1 - 1.9e-31 107.8 0.5 6.9e-21 74.0 0.3 4.6 6 0 0 6 6 6 2 twin BRCT domain BRCT PF00533.26 EMD61564.1 - 1.3e-25 89.5 0.0 6.9e-09 36.0 0.0 5.7 5 1 0 5 5 5 4 BRCA1 C Terminus (BRCT) domain RTT107_BRCT_5 PF16770.5 EMD61564.1 - 1.9e-25 88.6 0.2 5.1e-22 77.6 0.2 4.0 4 0 0 4 4 4 1 Regulator of Ty1 transposition protein 107 BRCT domain BRCT_2 PF16589.5 EMD61564.1 - 2.7e-20 72.5 0.4 0.00016 22.0 0.0 6.7 7 0 0 7 7 7 4 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 EMD61564.1 - 6.9e-05 23.1 0.0 0.27 11.6 0.0 2.8 2 0 0 2 2 2 2 DNA ligase 3 BRCT domain NIBRIN_BRCT_II PF16508.5 EMD61564.1 - 0.024 15.0 0.2 0.45 10.8 0.0 2.9 4 0 0 4 4 4 0 Second BRCT domain on Nijmegen syndrome breakage protein Abhydrolase_6 PF12697.7 EMD61565.1 - 1.1e-12 49.1 0.1 1.6e-12 48.5 0.1 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EMD61565.1 - 2.9e-08 33.3 0.0 4.3e-08 32.7 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EMD61565.1 - 0.00011 21.9 0.0 0.00018 21.3 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Chlorophyllase2 PF12740.7 EMD61565.1 - 0.043 12.7 0.0 0.088 11.7 0.0 1.5 1 0 0 1 1 1 0 Chlorophyllase enzyme Peptidase_S10 PF00450.22 EMD61565.1 - 0.054 12.9 0.0 0.075 12.4 0.0 1.2 1 0 0 1 1 1 0 Serine carboxypeptidase Esterase PF00756.20 EMD61565.1 - 0.14 11.8 0.0 0.22 11.1 0.0 1.3 1 0 0 1 1 1 0 Putative esterase PGAP1 PF07819.13 EMD61565.1 - 0.15 11.7 0.0 0.38 10.4 0.0 1.6 2 0 0 2 2 2 0 PGAP1-like protein Tocopherol_cycl PF14249.6 EMD61566.1 - 1.1e-06 28.1 2.4 6.8e-06 25.4 2.4 2.2 1 1 0 1 1 1 1 Tocopherol cyclase Gly_transf_sug PF04488.15 EMD61567.1 - 4e-09 37.0 0.0 9.1e-09 35.8 0.0 1.6 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Caps_synth PF05704.12 EMD61567.1 - 0.00061 19.3 0.0 0.0011 18.4 0.0 1.4 1 1 0 1 1 1 1 Capsular polysaccharide synthesis protein DIT1_PvcA PF05141.12 EMD61568.1 - 4.2e-87 292.1 0.0 5.5e-87 291.8 0.0 1.1 1 0 0 1 1 1 1 Pyoverdine/dityrosine biosynthesis protein Amidase PF01425.21 EMD61569.1 - 4.1e-35 121.6 0.2 2.2e-34 119.2 0.1 2.0 2 0 0 2 2 2 1 Amidase MFS_1 PF07690.16 EMD61570.1 - 2.3e-25 89.3 64.5 1.2e-24 86.9 44.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2306 PF10067.9 EMD61570.1 - 0.089 13.0 9.1 0.064 13.5 5.0 2.6 1 1 1 2 2 2 0 Predicted membrane protein (DUF2306) DIT1_PvcA PF05141.12 EMD61571.1 - 9.9e-79 264.7 0.0 1.2e-78 264.4 0.0 1.1 1 0 0 1 1 1 1 Pyoverdine/dityrosine biosynthesis protein EspA PF03433.13 EMD61572.1 - 0.075 12.9 1.3 0.13 12.1 0.7 1.7 2 0 0 2 2 2 0 EspA-like secreted protein Nucleolin_bd PF16725.5 EMD61572.1 - 0.24 11.1 2.9 0.71 9.6 0.3 2.8 3 0 0 3 3 3 0 Nucleolin binding domain Glyco_hydro_18 PF00704.28 EMD61573.1 - 2.5e-50 172.0 1.8 4.4e-50 171.2 1.8 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Chitin_bind_1 PF00187.19 EMD61573.1 - 1.1e-06 29.0 12.6 1.1e-06 29.0 12.6 3.4 3 0 0 3 3 3 2 Chitin recognition protein BSP_II PF05432.11 EMD61573.1 - 0.029 14.1 4.6 0.063 13.0 4.6 1.5 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Sporozoite_P67 PF05642.11 EMD61573.1 - 2.3 6.2 12.1 5.8 4.9 11.8 1.7 1 1 0 1 1 1 0 Sporozoite P67 surface antigen Chitin_bind_1 PF00187.19 EMD61575.1 - 9.5e-21 74.0 159.4 9.5e-06 26.0 15.2 8.0 7 0 0 7 7 7 5 Chitin recognition protein LysM PF01476.20 EMD61575.1 - 0.0058 16.7 0.0 0.01 15.9 0.0 1.4 1 0 0 1 1 1 1 LysM domain Plug PF07715.15 EMD61576.1 - 2 9.0 7.3 2.3 8.8 0.7 2.5 2 1 0 2 2 2 0 TonB-dependent Receptor Plug Domain ApbA PF02558.16 EMD61579.1 - 0.012 15.3 0.0 0.018 14.7 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA CDP-OH_P_transf PF01066.21 EMD61579.1 - 0.069 13.9 0.1 0.18 12.6 0.0 1.8 2 0 0 2 2 2 0 CDP-alcohol phosphatidyltransferase CorA PF01544.18 EMD61580.1 - 5e-16 58.9 0.3 6.5e-16 58.5 0.3 1.0 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein P3A PF08727.11 EMD61580.1 - 0.0087 15.4 0.0 0.023 14.1 0.0 1.7 1 0 0 1 1 1 1 Poliovirus 3A protein like DUF2306 PF10067.9 EMD61581.1 - 4e-14 53.1 11.1 4e-14 53.1 11.1 1.8 2 0 0 2 2 2 1 Predicted membrane protein (DUF2306) Transp_cyt_pur PF02133.15 EMD61582.1 - 3.3e-24 85.5 40.2 5.9e-24 84.6 40.2 1.4 1 1 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Nramp PF01566.18 EMD61582.1 - 2.1e-06 27.0 28.4 1.8e-05 23.9 20.3 2.4 2 1 0 2 2 2 2 Natural resistance-associated macrophage protein Beta_elim_lyase PF01212.21 EMD61583.1 - 1.7e-52 178.5 0.0 2.3e-52 178.1 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 EMD61583.1 - 0.0002 20.8 0.2 0.00057 19.3 0.1 1.6 1 1 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_1_2 PF00155.21 EMD61583.1 - 0.0024 17.1 0.1 0.0048 16.1 0.1 1.5 1 1 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EMD61583.1 - 0.03 12.9 0.0 0.045 12.3 0.0 1.3 1 1 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme Hpt PF01627.23 EMD61583.1 - 0.059 13.6 0.0 0.14 12.4 0.0 1.7 1 0 0 1 1 1 0 Hpt domain BTB PF00651.31 EMD61587.1 - 6.9e-05 23.0 0.0 0.0001 22.5 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain HIP1_clath_bdg PF16515.5 EMD61588.1 - 0.037 14.6 27.6 0.044 14.4 2.6 4.6 5 0 0 5 5 5 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Bombinin PF05298.11 EMD61588.1 - 0.044 13.5 0.5 0.16 11.6 0.0 2.2 2 0 0 2 2 2 0 Bombinin Spc7 PF08317.11 EMD61588.1 - 0.74 8.6 23.8 1.1 8.1 7.4 3.4 3 0 0 3 3 3 0 Spc7 kinetochore protein BLOC1_2 PF10046.9 EMD61588.1 - 0.85 10.0 11.8 0.78 10.1 1.2 3.7 3 1 1 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Katanin_con80 PF13925.6 EMD61588.1 - 1.3 9.0 6.1 1.3 9.1 2.2 2.9 2 1 0 2 2 2 0 con80 domain of Katanin DUF724 PF05266.14 EMD61588.1 - 5 6.9 25.7 11 5.8 10.0 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF724) Sec34 PF04136.15 EMD61589.1 - 0.0085 16.0 1.4 0.0085 16.0 1.4 2.8 3 0 0 3 3 3 1 Sec34-like family Med11 PF10280.9 EMD61589.1 - 0.0099 16.3 5.8 0.2 12.1 0.6 2.9 2 1 1 3 3 3 1 Mediator complex protein Cep57_MT_bd PF06657.13 EMD61589.1 - 0.021 15.3 8.6 1.7 9.2 0.0 4.2 3 1 0 3 3 3 0 Centrosome microtubule-binding domain of Cep57 Baculo_PEP_C PF04513.12 EMD61589.1 - 0.036 14.1 13.0 0.092 12.8 0.1 3.5 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Imm6 PF14434.6 EMD61589.1 - 0.063 13.2 0.0 0.16 11.9 0.0 1.6 1 0 0 1 1 1 0 Immunity protein Imm6 Glyco_hydro_67N PF03648.14 EMD61589.1 - 0.075 13.3 0.2 0.19 12.0 0.2 1.7 1 0 0 1 1 1 0 Glycosyl hydrolase family 67 N-terminus AKNA PF12443.8 EMD61589.1 - 0.098 13.3 3.6 0.81 10.4 1.5 2.8 2 0 0 2 2 2 0 AT-hook-containing transcription factor PDE4_UCR PF18100.1 EMD61589.1 - 0.22 12.2 2.8 0.22 12.2 0.3 2.2 2 0 0 2 2 2 0 Phosphodiesterase 4 upstream conserved regions (UCR) DUF1319 PF07028.11 EMD61589.1 - 0.27 11.5 7.1 18 5.6 0.1 4.0 3 1 1 4 4 4 0 Protein of unknown function (DUF1319) GAS PF13851.6 EMD61589.1 - 0.97 8.7 13.0 0.77 9.1 2.3 3.3 4 0 0 4 4 4 0 Growth-arrest specific micro-tubule binding Tropomyosin_1 PF12718.7 EMD61589.1 - 1.5 8.9 12.7 2.1 8.5 3.7 3.2 3 0 0 3 3 3 0 Tropomyosin like APG6_N PF17675.1 EMD61589.1 - 2.1 8.9 14.5 2 8.9 2.1 3.2 3 1 0 3 3 3 0 Apg6 coiled-coil region Tho2 PF11262.8 EMD61589.1 - 3.3 6.8 9.5 4.7 6.3 0.0 3.1 1 1 1 3 3 3 0 Transcription factor/nuclear export subunit protein 2 Seryl_tRNA_N PF02403.22 EMD61589.1 - 4.4 7.6 14.1 4.7 7.5 3.9 3.3 3 1 0 3 3 3 0 Seryl-tRNA synthetase N-terminal domain Pkinase PF00069.25 EMD61590.1 - 0.00071 19.0 0.0 0.00075 18.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Ank_4 PF13637.6 EMD61591.1 - 7.2e-14 52.0 3.7 1.5e-05 25.4 0.1 3.9 4 0 0 4 4 4 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EMD61591.1 - 1.6e-12 47.9 0.5 9.3e-05 22.9 0.0 4.1 2 2 2 4 4 4 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EMD61591.1 - 1e-10 40.9 3.0 0.0043 17.4 0.0 7.3 8 0 0 8 8 8 3 Ankyrin repeat Ank_5 PF13857.6 EMD61591.1 - 4.7e-08 33.2 4.2 4e-05 23.8 0.0 4.1 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank PF00023.30 EMD61591.1 - 3e-06 27.4 1.9 0.016 15.6 0.0 4.8 5 0 0 5 5 5 1 Ankyrin repeat GFA PF04828.14 EMD61592.1 - 1.1e-18 67.3 0.1 1.9e-18 66.6 0.1 1.4 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme NOB1_Zn_bind PF08772.11 EMD61592.1 - 0.15 12.3 2.0 6.8 6.9 0.0 2.5 2 0 0 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like SNF2_N PF00176.23 EMD61593.1 - 2.1e-18 66.2 0.0 3.6e-18 65.4 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EMD61593.1 - 4.1e-11 43.2 0.0 8.8e-11 42.1 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF2570 PF10828.8 EMD61594.1 - 0.09 12.6 0.2 0.23 11.3 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2570) DUF3435 PF11917.8 EMD61597.1 - 0.0013 17.7 0.0 0.0022 17.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3435) Phage_integrase PF00589.22 EMD61597.1 - 0.028 14.2 0.1 0.084 12.7 0.0 1.8 2 0 0 2 2 2 0 Phage integrase family zf-C2H2_aberr PF17017.5 EMD61597.1 - 0.04 14.1 0.1 0.082 13.1 0.1 1.4 1 0 0 1 1 1 0 Aberrant zinc-finger zf-Di19 PF05605.12 EMD61597.1 - 0.089 13.1 0.1 0.23 11.8 0.1 1.7 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding DUF1768 PF08719.11 EMD61598.1 - 3.7e-37 128.1 0.1 4.2e-37 127.9 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1768) AlaDh_PNT_N PF05222.15 EMD61598.1 - 0.1 12.9 0.0 0.13 12.6 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, N-terminal domain Arginase PF00491.21 EMD61599.1 - 3.9e-95 318.5 0.0 4.6e-95 318.3 0.0 1.0 1 0 0 1 1 1 1 Arginase family UPF0489 PF12640.7 EMD61599.1 - 0.0013 19.0 0.6 0.0062 16.8 0.1 2.1 2 0 0 2 2 2 1 UPF0489 domain Fapy_DNA_glyco PF01149.24 EMD61600.1 - 1.9e-33 115.5 1.0 3.1e-33 114.8 0.0 1.9 2 0 0 2 2 2 1 Formamidopyrimidine-DNA glycosylase N-terminal domain H2TH PF06831.14 EMD61600.1 - 2.6e-21 75.4 0.0 1.2e-20 73.3 0.0 2.0 2 0 0 2 2 2 1 Formamidopyrimidine-DNA glycosylase H2TH domain NARP1 PF12569.8 EMD61601.1 - 8.3e-212 704.7 28.4 1.1e-211 704.2 24.5 2.3 2 0 0 2 2 2 1 NMDA receptor-regulated protein 1 TPR_19 PF14559.6 EMD61601.1 - 2.3e-18 66.4 22.3 0.00031 21.2 0.1 7.4 8 0 0 8 8 7 5 Tetratricopeptide repeat TPR_2 PF07719.17 EMD61601.1 - 6.5e-16 57.1 27.6 0.013 15.5 0.0 10.9 11 0 0 11 11 11 6 Tetratricopeptide repeat TPR_14 PF13428.6 EMD61601.1 - 6.5e-12 45.2 14.1 4.8 8.3 0.0 10.4 7 3 4 11 11 10 2 Tetratricopeptide repeat TPR_16 PF13432.6 EMD61601.1 - 5e-10 39.9 22.3 0.00013 22.5 0.9 8.3 9 0 0 9 9 7 2 Tetratricopeptide repeat TPR_9 PF13371.6 EMD61601.1 - 7e-10 38.9 8.8 0.0033 17.6 0.0 5.7 4 2 1 5 5 5 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EMD61601.1 - 7.7e-10 38.9 16.8 0.016 15.4 0.2 6.0 5 1 1 6 6 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 EMD61601.1 - 1.6e-08 34.1 15.8 0.49 10.7 0.1 8.5 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_1 PF00515.28 EMD61601.1 - 2.2e-08 33.5 26.3 0.0059 16.4 0.0 9.1 10 0 0 10 10 10 2 Tetratricopeptide repeat TPR_17 PF13431.6 EMD61601.1 - 1.4e-07 31.4 7.6 0.15 12.5 0.0 7.2 7 0 0 7 7 6 1 Tetratricopeptide repeat TPR_11 PF13414.6 EMD61601.1 - 6.5e-07 28.9 5.5 0.014 15.0 0.1 4.4 5 0 0 5 5 4 2 TPR repeat TPR_12 PF13424.6 EMD61601.1 - 1.5e-06 28.4 16.5 1.2 9.5 0.1 8.0 6 1 2 8 8 8 2 Tetratricopeptide repeat Fungal_trans_2 PF11951.8 EMD61601.1 - 5e-06 25.6 1.1 1e-05 24.6 1.1 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain TPR_10 PF13374.6 EMD61601.1 - 0.00055 19.7 5.1 0.68 9.9 0.0 5.8 6 0 0 6 6 6 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EMD61601.1 - 0.0015 18.6 11.5 8.2 6.6 0.0 6.4 6 0 0 6 6 5 0 Fis1 C-terminal tetratricopeptide repeat Zn_clus PF00172.18 EMD61601.1 - 0.0016 18.5 2.0 0.0041 17.2 2.0 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Alkyl_sulf_dimr PF14863.6 EMD61601.1 - 0.0016 18.9 4.3 0.58 10.6 0.2 3.9 3 0 0 3 3 3 2 Alkyl sulfatase dimerisation TPR_4 PF07721.14 EMD61601.1 - 0.0031 18.0 0.9 1 10.2 0.0 3.8 2 0 0 2 2 2 1 Tetratricopeptide repeat DUF3287 PF11690.8 EMD61601.1 - 0.013 15.2 2.2 0.12 12.1 0.0 2.9 3 0 0 3 3 2 0 Protein of unknown function (DUF3287) TPR_7 PF13176.6 EMD61601.1 - 0.03 14.4 13.6 3 8.1 0.0 7.2 7 1 1 8 8 6 0 Tetratricopeptide repeat IHABP4_N PF16174.5 EMD61601.1 - 0.19 12.3 10.9 0.49 11.0 10.9 1.6 1 0 0 1 1 1 0 Intracellular hyaluronan-binding protein 4 N-terminal PPTA PF01239.22 EMD61601.1 - 0.22 11.3 0.9 17 5.3 0.0 3.4 3 0 0 3 3 3 0 Protein prenyltransferase alpha subunit repeat Opy2 PF09463.10 EMD61601.1 - 0.28 11.5 2.3 0.54 10.6 2.3 1.5 1 0 0 1 1 1 0 Opy2 protein bZIP_1 PF00170.21 EMD61605.1 - 0.00028 20.9 8.3 0.00045 20.3 8.3 1.2 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EMD61605.1 - 0.0041 17.2 7.8 0.0058 16.7 7.8 1.2 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 EMD61605.1 - 0.0089 16.5 2.3 0.014 15.9 2.3 1.2 1 0 0 1 1 1 1 bZIP Maf transcription factor MAP65_ASE1 PF03999.12 EMD61605.1 - 1.3 7.7 6.1 1.6 7.3 6.1 1.0 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) Rrn6 PF10214.9 EMD61605.1 - 5.4 5.4 12.4 6.4 5.1 12.4 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor AAA PF00004.29 EMD61606.1 - 1.4e-15 57.9 0.0 2.5e-15 57.1 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EMD61606.1 - 1.2e-11 45.3 0.0 9.3e-11 42.4 0.0 2.5 2 1 0 2 2 2 1 AAA ATPase domain AAA_lid_10 PF17872.1 EMD61606.1 - 1.3e-11 44.4 0.5 3.9e-11 42.9 0.1 1.9 2 0 0 2 2 2 1 AAA lid domain AAA_22 PF13401.6 EMD61606.1 - 2.2e-09 37.7 0.0 8e-09 35.9 0.0 1.9 2 0 0 2 2 2 1 AAA domain BAH PF01426.18 EMD61606.1 - 6.9e-08 32.4 0.1 1.7e-07 31.1 0.1 1.6 1 0 0 1 1 1 1 BAH domain AAA_19 PF13245.6 EMD61606.1 - 0.00068 20.0 0.0 0.0016 18.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 EMD61606.1 - 0.01 15.6 0.0 0.024 14.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 EMD61606.1 - 0.011 15.6 0.0 0.027 14.4 0.0 1.6 1 1 0 1 1 1 0 NACHT domain AAA_28 PF13521.6 EMD61606.1 - 0.019 15.2 0.0 0.042 14.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.9 EMD61606.1 - 0.046 12.9 0.0 0.072 12.3 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_32 PF13654.6 EMD61606.1 - 0.048 12.4 0.0 0.078 11.8 0.0 1.2 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 EMD61606.1 - 0.055 13.4 0.0 0.81 9.6 0.0 2.3 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea TsaE PF02367.17 EMD61606.1 - 0.059 13.4 0.0 0.39 10.7 0.0 2.0 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_18 PF13238.6 EMD61606.1 - 0.09 13.3 0.0 0.19 12.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain PIF1 PF05970.14 EMD61606.1 - 0.094 11.9 0.0 0.16 11.1 0.0 1.2 1 0 0 1 1 1 0 PIF1-like helicase ssDBP PF17878.1 EMD61606.1 - 0.12 12.6 0.0 0.27 11.5 0.0 1.5 1 0 0 1 1 1 0 Single-stranded DNA-binding protein RNA_helicase PF00910.22 EMD61606.1 - 0.13 12.6 0.0 0.53 10.7 0.0 2.1 2 0 0 2 2 1 0 RNA helicase UvrD-helicase PF00580.21 EMD61606.1 - 0.13 11.7 0.0 0.3 10.6 0.0 1.5 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain ResIII PF04851.15 EMD61606.1 - 0.15 12.0 0.0 3 7.8 0.0 2.9 3 2 0 3 3 3 0 Type III restriction enzyme, res subunit DDHD PF02862.17 EMD61607.1 - 4.6e-27 95.6 0.4 8.1e-16 58.9 0.0 2.9 2 1 1 3 3 3 2 DDHD domain Aldedh PF00171.22 EMD61608.1 - 1.4e-184 613.9 1.1 1.6e-184 613.7 1.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 EMD61608.1 - 0.00067 19.2 0.1 1.3 8.4 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF1487) RRM_1 PF00076.22 EMD61609.1 - 4.7e-10 39.1 0.0 7.5e-10 38.5 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication PF13865.6 EMD61609.1 - 2.6e-07 31.1 4.6 2.6e-07 31.1 4.6 2.6 2 0 0 2 2 2 1 C-terminal duplication domain of Friend of PRMT1 RRM_occluded PF16842.5 EMD61609.1 - 6.8e-05 22.7 0.0 0.00012 21.9 0.0 1.4 1 0 0 1 1 1 1 Occluded RNA-recognition motif FXMRP1_C_core PF12235.8 EMD61609.1 - 4 8.1 7.8 1.1 9.9 1.7 2.1 2 0 0 2 2 2 0 Fragile X-related 1 protein core C terminal Clathrin PF00637.20 EMD61610.1 - 2.2e-22 79.5 3.2 1.6e-20 73.4 2.6 2.5 2 0 0 2 2 2 1 Region in Clathrin and VPS VPS11_C PF12451.8 EMD61610.1 - 2.5e-20 72.4 0.1 7.6e-20 70.9 0.1 1.9 1 0 0 1 1 1 1 Vacuolar protein sorting protein 11 C terminal zf-C3HC4_2 PF13923.6 EMD61610.1 - 2.4e-07 30.5 8.4 4.7e-07 29.6 8.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EMD61610.1 - 1.7e-05 24.7 6.4 3.1e-05 23.8 6.4 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3H2C3 PF17122.5 EMD61610.1 - 2e-05 24.5 9.4 4.1e-05 23.5 9.4 1.6 1 0 0 1 1 1 1 Zinc-finger zf-RING_2 PF13639.6 EMD61610.1 - 0.0017 18.7 7.9 0.0031 17.8 7.9 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 EMD61610.1 - 0.0031 17.5 7.1 0.0093 16.0 7.1 1.9 1 0 0 1 1 1 1 RING-type zinc-finger TPR_11 PF13414.6 EMD61610.1 - 0.0075 15.9 0.3 0.027 14.1 0.3 2.0 1 0 0 1 1 1 1 TPR repeat Vps8 PF12816.7 EMD61610.1 - 0.024 14.2 0.4 0.15 11.5 0.0 2.2 1 1 1 2 2 2 0 Golgi CORVET complex core vacuolar protein 8 Vps39_2 PF10367.9 EMD61610.1 - 0.035 14.5 0.5 0.12 12.8 0.5 2.0 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 2 zf-ANAPC11 PF12861.7 EMD61610.1 - 0.04 14.0 2.2 0.091 12.8 2.2 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4 PF00097.25 EMD61610.1 - 0.054 13.4 7.8 0.1 12.5 7.8 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EMD61610.1 - 0.11 12.8 5.1 0.25 11.6 5.1 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger domain HypA PF01155.19 EMD61610.1 - 0.13 12.3 2.0 0.4 10.7 2.0 1.8 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-C3HC4_4 PF15227.6 EMD61610.1 - 0.15 12.3 7.7 0.29 11.3 7.7 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.6 EMD61610.1 - 0.52 10.2 5.6 0.91 9.4 5.6 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-Nse PF11789.8 EMD61610.1 - 0.92 9.4 4.2 2.2 8.2 4.2 1.6 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit KIP1 PF07765.12 EMD61610.1 - 2.6 8.2 4.2 0.84 9.8 0.7 2.0 2 0 0 2 2 1 0 KIP1-like protein PHD PF00628.29 EMD61610.1 - 2.9 7.8 7.4 5.8 6.9 7.4 1.5 1 0 0 1 1 1 0 PHD-finger zf-RING_11 PF17123.5 EMD61610.1 - 3.7 7.4 9.8 3.7 7.4 5.8 2.5 2 0 0 2 2 2 0 RING-like zinc finger Prok-RING_1 PF14446.6 EMD61610.1 - 6.9 6.7 7.3 1.5 8.8 2.1 2.3 1 1 1 2 2 2 0 Prokaryotic RING finger family 1 ANAPC3 PF12895.7 EMD61610.1 - 8.9 6.6 7.0 27 5.1 0.5 3.6 2 2 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 PXA PF02194.15 EMD61611.1 - 8.7e-50 169.2 0.4 2.2e-47 161.4 0.1 3.3 3 1 0 3 3 3 1 PXA domain Nexin_C PF08628.12 EMD61611.1 - 2.1e-25 89.5 0.1 6.2e-25 88.0 0.1 1.9 1 0 0 1 1 1 1 Sorting nexin C terminal PX PF00787.24 EMD61611.1 - 1.9e-20 72.9 0.1 4.4e-20 71.8 0.1 1.7 1 0 0 1 1 1 1 PX domain RGS PF00615.19 EMD61611.1 - 1e-11 45.2 1.3 1.5e-11 44.6 0.1 2.0 2 0 0 2 2 2 1 Regulator of G protein signaling domain CPDase PF07823.11 EMD61611.1 - 0.11 12.2 0.0 0.24 11.1 0.0 1.5 1 0 0 1 1 1 0 Cyclic phosphodiesterase-like protein CFEM PF05730.11 EMD61613.1 - 9.5e-14 51.2 10.8 1.8e-13 50.4 10.8 1.5 1 0 0 1 1 1 1 CFEM domain RAP1 PF07218.11 EMD61613.1 - 2.5 6.3 9.9 3.4 5.8 9.9 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) WD40 PF00400.32 EMD61615.1 - 1.6e-40 136.3 15.3 3.5e-07 30.8 0.1 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD61615.1 - 3.3e-07 30.5 2.0 0.92 9.9 0.1 5.5 2 2 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EMD61615.1 - 0.031 12.9 2.4 14 4.2 0.0 4.2 1 1 3 4 4 4 0 Nucleoporin Nup120/160 Peptidase_M32 PF02074.15 EMD61615.1 - 0.034 12.9 1.5 0.052 12.3 1.5 1.2 1 0 0 1 1 1 0 Carboxypeptidase Taq (M32) metallopeptidase ABC_tran_Xtn PF12848.7 EMD61615.1 - 0.63 10.1 5.5 1.4 9.0 5.5 1.5 1 0 0 1 1 1 0 ABC transporter AAA_11 PF13086.6 EMD61616.1 - 1.2e-19 71.1 0.3 2.9e-19 69.9 0.3 1.7 1 0 0 1 1 1 1 AAA domain AAA_12 PF13087.6 EMD61616.1 - 2e-19 70.0 0.0 4.2e-19 69.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EMD61616.1 - 2.5e-07 31.1 0.9 1.1e-06 29.0 0.9 2.1 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EMD61616.1 - 0.0002 21.1 0.1 0.036 13.8 0.0 2.6 2 0 0 2 2 2 2 AAA domain DUF2075 PF09848.9 EMD61616.1 - 0.027 13.7 0.0 0.06 12.6 0.0 1.6 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) adh_short_C2 PF13561.6 EMD61617.1 - 8.1e-58 195.7 5.2 9.2e-58 195.6 5.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EMD61617.1 - 1.2e-46 158.7 3.1 1.4e-46 158.4 3.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EMD61617.1 - 9e-11 42.0 1.7 1.9e-10 40.9 1.7 1.5 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EMD61617.1 - 0.017 14.6 0.9 0.16 11.4 0.9 2.3 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Wax2_C PF12076.8 EMD61617.1 - 0.029 14.1 0.0 0.042 13.6 0.0 1.3 1 0 0 1 1 1 0 WAX2 C-terminal domain DUF4332 PF14229.6 EMD61617.1 - 0.067 13.4 0.1 0.11 12.8 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4332) HCV_NS1 PF01560.17 EMD61617.1 - 0.11 11.1 0.0 0.18 10.5 0.0 1.3 1 0 0 1 1 1 0 Hepatitis C virus non-structural protein E2/NS1 Methyltransf_PK PF05891.12 EMD61617.1 - 0.12 11.9 0.0 0.16 11.4 0.0 1.2 1 0 0 1 1 1 0 AdoMet dependent proline di-methyltransferase Xan_ur_permease PF00860.20 EMD61619.1 - 2.1e-25 89.2 27.9 3e-24 85.5 27.9 2.5 1 1 0 1 1 1 1 Permease family MFS_MOT1 PF16983.5 EMD61619.1 - 0.002 18.5 4.7 0.002 18.5 4.7 2.9 3 0 0 3 3 3 1 Molybdate transporter of MFS superfamily DUF3488 PF11992.8 EMD61619.1 - 0.044 12.7 2.7 0.11 11.4 2.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3488) DUF2834 PF11196.8 EMD61619.1 - 0.33 11.3 4.1 1.2 9.6 4.1 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2834) DUF5413 PF17434.2 EMD61619.1 - 2.7 8.3 8.4 0.32 11.3 2.4 2.4 2 1 0 2 2 2 0 Family of unknown function (DUF5413) DUF1772 PF08592.11 EMD61619.1 - 9.7 6.5 7.6 6.5 7.1 0.1 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF1772) Cdc6_C PF09079.11 EMD61620.1 - 0.14 12.1 0.0 0.38 10.7 0.0 1.7 1 0 0 1 1 1 0 CDC6, C terminal winged helix domain AhpC-TSA_2 PF13911.6 EMD61621.1 - 4.9e-08 33.1 0.0 8.5e-08 32.3 0.0 1.4 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme AhpC-TSA PF00578.21 EMD61621.1 - 0.0013 18.7 0.0 0.0019 18.1 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family NAD_binding_8 PF13450.6 EMD61622.1 - 8.8e-12 45.1 0.1 2.7e-11 43.5 0.1 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 EMD61622.1 - 1.5e-08 34.4 0.0 3.3e-08 33.2 0.0 1.7 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase FAD_binding_3 PF01494.19 EMD61622.1 - 2.6e-06 26.9 0.0 4.9e-06 26.0 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.6 EMD61622.1 - 3e-06 26.7 0.1 4.6e-06 26.1 0.1 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EMD61622.1 - 1.3e-05 24.1 0.5 2.1e-05 23.4 0.5 1.3 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_2 PF07992.14 EMD61622.1 - 0.0001 21.7 0.1 0.00016 21.0 0.1 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EMD61622.1 - 0.0001 21.5 0.0 0.00039 19.6 0.0 1.8 2 0 0 2 2 2 1 FAD binding domain FAD_oxidored PF12831.7 EMD61622.1 - 0.0022 17.4 0.1 0.0031 16.9 0.1 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 EMD61622.1 - 0.0036 16.6 0.0 0.0059 15.9 0.0 1.2 1 0 0 1 1 1 1 Thi4 family Lycopene_cycl PF05834.12 EMD61622.1 - 0.0041 16.2 0.0 0.0058 15.7 0.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein DAO PF01266.24 EMD61622.1 - 0.012 15.2 0.0 0.016 14.8 0.0 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.21 EMD61622.1 - 0.026 13.8 0.0 0.045 13.1 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain IlvN PF07991.12 EMD61622.1 - 0.056 13.0 0.0 0.1 12.2 0.0 1.3 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain 2-Hacid_dh_C PF02826.19 EMD61622.1 - 0.062 12.7 0.0 0.12 11.7 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GIDA PF01134.22 EMD61622.1 - 0.069 12.2 0.2 0.1 11.7 0.2 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A DJ-1_PfpI PF01965.24 EMD61622.1 - 0.085 12.7 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 DJ-1/PfpI family NAD_binding_9 PF13454.6 EMD61622.1 - 0.13 12.2 0.0 0.25 11.3 0.0 1.4 1 0 0 1 1 1 0 FAD-NAD(P)-binding Pyr_redox PF00070.27 EMD61622.1 - 0.14 12.8 0.0 0.28 11.8 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase GMC_oxred_N PF00732.19 EMD61625.1 - 1.7e-20 73.6 0.1 1.5e-13 50.8 0.0 3.1 1 1 1 2 2 2 2 GMC oxidoreductase GMC_oxred_C PF05199.13 EMD61625.1 - 2.5e-12 47.5 0.0 4.8e-12 46.6 0.0 1.5 1 0 0 1 1 1 1 GMC oxidoreductase Pyr_redox_3 PF13738.6 EMD61625.1 - 0.0034 16.7 0.0 0.28 10.4 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Glyco_hydro_49 PF03718.13 EMD61625.1 - 0.021 14.8 0.7 3.8 7.5 0.0 2.5 2 0 0 2 2 2 0 Glycosyl hydrolase family 49 DeoRC PF00455.22 EMD61625.1 - 0.082 12.8 0.1 0.24 11.3 0.1 1.8 1 0 0 1 1 1 0 DeoR C terminal sensor domain Frag1 PF10277.9 EMD61626.1 - 0.088 12.3 8.4 0.12 11.9 8.0 1.5 1 1 0 1 1 1 0 Frag1/DRAM/Sfk1 family Glyco_hydro_88 PF07470.13 EMD61627.1 - 6.1e-66 222.8 8.6 8.3e-66 222.4 8.6 1.1 1 0 0 1 1 1 1 Glycosyl Hydrolase Family 88 TOH_N PF12549.8 EMD61628.1 - 4.6 7.2 6.9 0.35 10.8 1.0 2.3 2 1 1 3 3 3 0 Tyrosine hydroxylase N terminal DEAD PF00270.29 EMD61629.1 - 1.7e-46 158.2 0.0 3.7e-46 157.1 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EMD61629.1 - 1.2e-24 86.8 0.0 7e-24 84.3 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EMD61629.1 - 3e-18 65.8 0.2 8.6e-18 64.3 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4217) Helicase_C_2 PF13307.6 EMD61629.1 - 0.16 12.2 1.2 0.29 11.3 0.0 2.1 2 0 0 2 2 2 0 Helicase C-terminal domain CMS1 PF14617.6 EMD61629.1 - 0.18 11.1 0.0 0.18 11.1 0.0 5.0 4 1 1 5 5 5 0 U3-containing 90S pre-ribosomal complex subunit Coat_X PF07552.11 EMD61629.1 - 0.43 10.4 1.2 1.1 9.2 1.2 1.6 1 0 0 1 1 1 0 Spore Coat Protein X and V domain DnaJ PF00226.31 EMD61630.1 - 2.5e-13 49.9 0.3 8e-13 48.3 0.3 1.9 1 0 0 1 1 1 1 DnaJ domain Zn_clus PF00172.18 EMD61631.1 - 0.00019 21.5 11.6 0.00028 20.9 11.6 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Cys_Knot_tox PF17486.2 EMD61632.1 - 0.019 15.2 7.4 0.032 14.4 7.4 1.4 1 0 0 1 1 1 0 Cystine knot toxins DEAD PF00270.29 EMD61633.1 - 5.6e-49 166.3 0.0 2.3e-48 164.3 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EMD61633.1 - 1.1e-27 96.6 0.1 6.2e-26 90.9 0.1 2.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DBP10CT PF08147.12 EMD61633.1 - 3e-21 75.4 5.0 3e-21 75.4 5.0 2.5 2 0 0 2 2 2 1 DBP10CT (NUC160) domain RPA_C PF08784.11 EMD61634.1 - 7.9e-18 65.0 0.1 2.3e-17 63.5 0.0 1.8 2 0 0 2 2 2 1 Replication protein A C terminal tRNA_anti-codon PF01336.25 EMD61634.1 - 1.2e-07 31.6 0.0 4.3e-07 29.8 0.0 1.9 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain MarR_2 PF12802.7 EMD61634.1 - 0.017 15.0 0.0 0.036 14.0 0.0 1.5 1 0 0 1 1 1 0 MarR family DUF202 PF02656.15 EMD61635.1 - 1.9e-15 57.1 1.0 1.9e-15 57.1 1.0 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF202) COX4_pro_2 PF07835.12 EMD61635.1 - 0.13 12.4 0.1 0.13 12.4 0.1 2.2 2 0 0 2 2 2 0 Bacterial aa3 type cytochrome c oxidase subunit IV CIA30 PF08547.12 EMD61636.1 - 6e-40 136.9 0.1 9.9e-40 136.2 0.1 1.3 1 0 0 1 1 1 1 Complex I intermediate-associated protein 30 (CIA30) Homeodomain PF00046.29 EMD61637.1 - 2.8e-13 49.5 0.6 7.3e-13 48.2 0.6 1.7 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EMD61637.1 - 2.2 8.3 5.6 0.22 11.5 0.2 2.2 3 0 0 3 3 3 0 Homeobox KN domain HAD_2 PF13419.6 EMD61638.1 - 4.8e-20 72.4 0.0 6.5e-20 72.0 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EMD61638.1 - 7.8e-10 39.4 0.0 7.8e-06 26.3 0.0 2.1 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 EMD61638.1 - 1.3e-06 29.0 0.0 2.3e-06 28.2 0.0 1.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 EMD61638.1 - 0.0034 17.5 0.0 0.06 13.5 0.0 2.6 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EMD61638.1 - 0.031 14.4 0.0 0.057 13.5 0.0 1.5 1 0 0 1 1 1 0 HAD-hyrolase-like Hydrolase_3 PF08282.12 EMD61638.1 - 0.066 12.9 0.0 0.17 11.6 0.0 1.7 1 1 1 2 2 2 0 haloacid dehalogenase-like hydrolase GN3L_Grn1 PF08701.11 EMD61639.1 - 4.1e-24 84.5 17.5 1.3e-23 82.9 17.5 1.9 1 0 0 1 1 1 1 GNL3L/Grn1 putative GTPase MMR_HSR1 PF01926.23 EMD61639.1 - 2.6e-17 62.9 0.1 4.9e-13 49.2 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EMD61639.1 - 5.9e-06 26.3 0.2 5.9e-05 23.0 0.2 2.2 1 1 0 1 1 1 1 RsgA GTPase FeoB_N PF02421.18 EMD61639.1 - 1.4e-05 24.6 0.3 4.5e-05 23.0 0.0 1.9 2 0 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EMD61639.1 - 1.9e-05 24.8 9.0 0.036 14.1 2.2 4.0 2 2 0 3 3 3 2 Dynamin family GTP_EFTU PF00009.27 EMD61639.1 - 0.0002 20.9 0.0 0.1 12.1 0.0 2.7 2 1 0 2 2 2 2 Elongation factor Tu GTP binding domain Arf PF00025.21 EMD61639.1 - 0.0049 16.3 0.1 0.66 9.4 0.0 2.6 2 0 0 2 2 2 1 ADP-ribosylation factor family AAA_18 PF13238.6 EMD61639.1 - 0.017 15.7 3.2 0.023 15.2 0.0 2.4 2 0 0 2 2 2 0 AAA domain MeaB PF03308.16 EMD61639.1 - 0.045 12.7 0.1 0.045 12.7 0.1 1.9 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Roc PF08477.13 EMD61639.1 - 0.072 13.3 0.2 5.2 7.3 0.0 2.4 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_23 PF13476.6 EMD61639.1 - 0.9 10.0 0.0 0.9 10.0 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 EMD61639.1 - 1.1 9.6 0.0 1.1 9.6 0.0 2.9 2 1 0 2 2 1 0 AAA ATPase domain YqfQ PF14181.6 EMD61639.1 - 9.1 6.4 0.0 9.1 6.4 0.0 3.7 3 1 0 3 3 2 0 YqfQ-like protein Aldedh PF00171.22 EMD61640.1 - 3.5e-107 358.8 0.0 4.2e-107 358.5 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family SRP9-21 PF05486.12 EMD61640.1 - 0.05 14.0 0.0 0.095 13.1 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle 9 kDa protein (SRP9) MFS_1 PF07690.16 EMD61641.1 - 2.5e-37 128.6 42.6 2.5e-37 128.6 42.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Glyco_hydro_47 PF01532.20 EMD61642.1 - 4.7e-161 536.7 0.0 5.4e-161 536.5 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 CI-B14_5a PF07347.12 EMD61642.1 - 0.11 12.3 0.2 0.23 11.4 0.2 1.4 1 0 0 1 1 1 0 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a) Arrestin_N PF00339.29 EMD61643.1 - 1.2e-08 35.1 0.2 5.9e-08 32.9 0.1 2.1 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Vps26 PF03643.15 EMD61643.1 - 0.18 10.8 0.0 0.43 9.5 0.0 1.6 2 0 0 2 2 2 0 Vacuolar protein sorting-associated protein 26 Mito_carr PF00153.27 EMD61644.1 - 2.6e-50 168.3 2.7 1e-18 67.0 0.1 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein SPO11_like PF03533.14 EMD61644.1 - 0.69 10.0 3.7 0.42 10.7 0.5 2.2 2 0 0 2 2 2 0 SPO11 homologue DNA_pol_E_B PF04042.16 EMD61645.1 - 0.11 11.9 0.1 0.27 10.6 0.1 1.6 1 0 0 1 1 1 0 DNA polymerase alpha/epsilon subunit B Gryzun PF07919.12 EMD61647.1 - 1.2e-211 704.6 0.0 1.5e-211 704.3 0.0 1.1 1 0 0 1 1 1 1 Gryzun, putative trafficking through Golgi Foie-gras_1 PF11817.8 EMD61647.1 - 9.1e-98 327.0 2.5 1e-88 297.3 3.3 2.2 2 0 0 2 2 2 2 Foie gras liver health family 1 RXT2_N PF08595.11 EMD61648.1 - 2.1e-28 99.3 0.1 2.1e-28 99.3 0.1 3.3 3 2 1 4 4 4 1 RXT2-like, N-terminal RapA_C PF12137.8 EMD61648.1 - 9.7e-05 21.5 1.7 0.00019 20.6 1.7 1.4 1 0 0 1 1 1 1 RNA polymerase recycling family C-terminal MatP_C PF17414.2 EMD61648.1 - 0.0099 16.0 1.1 0.034 14.4 1.1 1.9 1 0 0 1 1 1 1 MatP C-terminal ribbon-helix-helix domain DUF1366 PF07104.11 EMD61648.1 - 0.018 14.8 2.0 0.054 13.2 2.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1366) GAS PF13851.6 EMD61648.1 - 0.023 14.0 5.8 0.053 12.9 5.8 1.5 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding IKBKB_SDD PF18397.1 EMD61648.1 - 0.045 13.0 2.8 0.08 12.2 2.8 1.3 1 0 0 1 1 1 0 IQBAL scaffold dimerization domain CdvA PF18822.1 EMD61648.1 - 0.06 13.2 2.0 0.16 11.8 2.0 1.7 1 0 0 1 1 1 0 CdvA-like coiled-coil domain T2SSG PF08334.11 EMD61648.1 - 0.083 13.0 0.8 4.4 7.4 0.8 2.5 1 1 0 1 1 1 0 Type II secretion system (T2SS), protein G Spc7 PF08317.11 EMD61648.1 - 0.15 11.0 6.2 0.31 9.9 6.2 1.5 1 0 0 1 1 1 0 Spc7 kinetochore protein Spc24 PF08286.11 EMD61648.1 - 0.32 11.3 2.7 1.5 9.1 1.8 2.6 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 YabA PF06156.13 EMD61648.1 - 2 9.1 6.7 1.9 9.1 3.7 2.4 2 0 0 2 2 2 0 Initiation control protein YabA MAD PF05557.13 EMD61648.1 - 2.6 6.3 11.7 0.087 11.2 5.3 1.7 2 0 0 2 2 2 0 Mitotic checkpoint protein 60KD_IMP PF02096.20 EMD61648.1 - 2.9 7.8 5.2 1.7 8.5 2.9 1.6 1 1 1 2 2 2 0 60Kd inner membrane protein Ax_dynein_light PF10211.9 EMD61648.1 - 4.8 7.1 8.0 1.9 8.4 2.1 2.6 2 0 0 2 2 2 0 Axonemal dynein light chain zf-C2H2_4 PF13894.6 EMD61649.1 - 0.0002 21.9 12.0 0.06 14.2 4.0 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger Acyltransf_C PF16076.5 EMD61649.1 - 0.0019 18.3 0.3 0.0038 17.3 0.3 1.5 1 0 0 1 1 1 1 Acyltransferase C-terminus zf-H2C2_2 PF13465.6 EMD61649.1 - 0.009 16.4 2.4 0.009 16.4 2.4 3.2 3 0 0 3 3 3 1 Zinc-finger double domain zf-BED PF02892.15 EMD61649.1 - 0.047 13.7 0.3 0.047 13.7 0.3 2.5 1 1 1 2 2 2 0 BED zinc finger zf-CHCC PF10276.9 EMD61649.1 - 0.11 12.6 6.3 0.74 9.9 0.3 2.4 2 0 0 2 2 2 0 Zinc-finger domain DZR PF12773.7 EMD61649.1 - 0.11 12.5 1.5 0.24 11.5 1.5 1.5 1 0 0 1 1 1 0 Double zinc ribbon zinc_ribbon_5 PF13719.6 EMD61649.1 - 0.12 12.2 2.9 4.6 7.1 0.5 2.3 2 0 0 2 2 2 0 zinc-ribbon domain zf-ribbon_3 PF13248.6 EMD61649.1 - 0.13 11.7 3.7 4.7 6.7 0.1 2.4 2 0 0 2 2 2 0 zinc-ribbon domain PyrI_C PF02748.15 EMD61649.1 - 0.39 10.7 3.1 2.8 7.9 0.3 2.3 2 0 0 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-Di19 PF05605.12 EMD61649.1 - 1 9.7 6.5 4.3 7.7 6.6 2.0 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_2 PF12756.7 EMD61649.1 - 1.7 9.0 7.2 3.3 8.1 3.1 2.3 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) BIR PF00653.21 EMD61649.1 - 2.3 8.9 5.1 16 6.3 0.1 2.6 1 1 1 2 2 2 0 Inhibitor of Apoptosis domain zf-C2H2 PF00096.26 EMD61649.1 - 10 6.8 19.0 2 9.0 5.0 3.5 2 1 0 2 2 2 0 Zinc finger, C2H2 type TraG-D_C PF12696.7 EMD61650.1 - 0.18 11.8 0.0 0.3 11.1 0.0 1.4 1 0 0 1 1 1 0 TraM recognition site of TraD and TraG Aminotran_5 PF00266.19 EMD61651.1 - 1.9e-24 86.3 0.0 3.6e-24 85.4 0.0 1.5 1 1 0 1 1 1 1 Aminotransferase class-V zf-C2H2 PF00096.26 EMD61653.1 - 0.82 10.3 4.2 0.41 11.2 0.7 2.4 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMD61655.1 - 0.0097 16.3 0.1 0.0097 16.3 0.1 3.0 3 0 0 3 3 3 1 Zinc-finger double domain zf-BED PF02892.15 EMD61655.1 - 0.011 15.7 2.0 2.9 8.0 0.1 2.6 2 0 0 2 2 2 0 BED zinc finger zf-C2H2_4 PF13894.6 EMD61655.1 - 0.016 16.0 11.3 0.57 11.2 0.6 3.2 3 0 0 3 3 3 0 C2H2-type zinc finger zf-RRPl_C4 PF17026.5 EMD61655.1 - 0.028 14.5 0.1 0.054 13.6 0.1 1.4 1 0 0 1 1 1 0 Putative ribonucleoprotein zinc-finger pf C4 type zf-C2H2 PF00096.26 EMD61655.1 - 0.19 12.3 0.3 0.19 12.3 0.3 3.8 3 1 0 3 3 3 0 Zinc finger, C2H2 type zf-H2C2_5 PF13909.6 EMD61655.1 - 0.31 10.8 9.1 0.36 10.6 4.6 3.1 2 1 0 2 2 2 0 C2H2-type zinc-finger domain GAPT PF11770.8 EMD61656.1 - 0.33 10.8 1.4 0.67 9.8 0.4 1.8 2 0 0 2 2 2 0 GRB2-binding adapter (GAPT) F-box-like PF12937.7 EMD61657.1 - 0.0004 20.2 0.1 0.00074 19.4 0.1 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EMD61657.1 - 0.036 13.9 0.0 0.097 12.6 0.0 1.7 1 0 0 1 1 1 0 F-box domain SprT-like PF10263.9 EMD61658.1 - 2.7e-16 59.4 0.0 5.5e-16 58.4 0.0 1.5 1 0 0 1 1 1 1 SprT-like family zf-WRNIP1_ubi PF18279.1 EMD61658.1 - 0.021 15.4 0.2 0.069 13.8 0.2 1.9 1 0 0 1 1 1 0 Werner helicase-interacting protein 1 ubiquitin-binding domain zf_UBZ PF18439.1 EMD61658.1 - 0.11 12.1 0.1 0.26 10.9 0.1 1.6 1 0 0 1 1 1 0 Ubiquitin-Binding Zinc Finger RabGAP-TBC PF00566.18 EMD61659.1 - 3.5e-48 164.1 0.0 5.6e-48 163.4 0.0 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain DUF1411 PF07199.11 EMD61659.1 - 0.06 13.0 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1411) YdfA_immunity PF12127.8 EMD61659.1 - 1.5 7.8 3.7 2.9 6.9 3.7 1.4 1 0 0 1 1 1 0 SigmaW regulon antibacterial SNF2_N PF00176.23 EMD61660.1 - 2.6e-55 187.6 0.1 4.9e-55 186.7 0.1 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Chromo PF00385.24 EMD61660.1 - 5.2e-23 80.7 3.7 1e-14 54.1 0.2 3.0 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Helicase_C PF00271.31 EMD61660.1 - 8.6e-20 71.1 0.0 2.5e-19 69.7 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF4208 PF13907.6 EMD61660.1 - 2.5e-16 59.9 1.7 5.2e-16 58.9 0.0 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4208) ResIII PF04851.15 EMD61660.1 - 9.3e-07 29.0 0.1 3.7e-06 27.1 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Cdh1_DBD_1 PF18196.1 EMD61660.1 - 0.00055 20.2 4.9 0.0038 17.5 0.4 5.3 5 1 1 6 6 6 2 Chromodomain helicase DNA-binding domain 1 AAA_22 PF13401.6 EMD61660.1 - 0.054 13.8 0.0 0.24 11.7 0.0 2.1 1 0 0 1 1 1 0 AAA domain CorA PF01544.18 EMD61663.1 - 9.9e-05 21.8 5.5 0.00067 19.1 0.4 2.9 2 1 0 2 2 2 2 CorA-like Mg2+ transporter protein DUF1604 PF07713.13 EMD61664.1 - 4.3e-40 135.4 1.6 4.3e-40 135.4 1.6 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF1604) G-patch PF01585.23 EMD61664.1 - 0.00041 20.2 0.3 0.0014 18.5 0.3 1.9 1 0 0 1 1 1 1 G-patch domain Pkinase PF00069.25 EMD61665.1 - 1.8e-70 237.3 0.0 2.7e-70 236.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD61665.1 - 7.9e-40 136.8 0.1 1.9e-39 135.5 0.1 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase KA1 PF02149.19 EMD61665.1 - 5.6e-18 64.5 0.1 1.1e-17 63.6 0.1 1.4 1 0 0 1 1 1 1 Kinase associated domain 1 Kinase-like PF14531.6 EMD61665.1 - 4.1e-06 26.3 0.0 3.4e-05 23.3 0.0 2.1 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 EMD61665.1 - 2.1e-05 23.6 0.0 3.2e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EMD61665.1 - 0.00029 20.3 0.1 0.00051 19.4 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EMD61665.1 - 0.0075 16.2 0.0 0.029 14.3 0.0 1.9 1 1 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 EMD61665.1 - 0.07 12.7 0.1 0.17 11.4 0.1 1.6 1 0 0 1 1 1 0 RIO1 family YrbL-PhoP_reg PF10707.9 EMD61665.1 - 0.071 12.6 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Rcd1 PF04078.13 EMD61666.1 - 1.9e-125 417.3 3.4 2.3e-125 417.1 3.4 1.1 1 0 0 1 1 1 1 Cell differentiation family, Rcd1-like TFIIA PF03153.13 EMD61666.1 - 4.6 7.1 11.5 5.9 6.8 11.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Ribosomal_L1 PF00687.21 EMD61667.1 - 4.1e-48 163.8 0.4 4.6e-48 163.7 0.4 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family SNF PF00209.18 EMD61667.1 - 0.062 12.0 0.0 0.085 11.5 0.0 1.1 1 0 0 1 1 1 0 Sodium:neurotransmitter symporter family DUF3671 PF12420.8 EMD61667.1 - 2.2 8.4 6.0 10 6.3 5.9 2.0 1 1 0 1 1 1 0 Protein of unknown function Cid2 PF09774.9 EMD61668.1 - 9.9e-56 188.6 0.0 1.2e-55 188.4 0.0 1.0 1 0 0 1 1 1 1 Caffeine-induced death protein 2 DNA_ligase_A_M PF01068.21 EMD61669.1 - 8.6e-61 205.1 5.7 1.3e-48 165.4 0.4 3.0 3 0 0 3 3 3 2 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 EMD61669.1 - 2.7e-43 148.3 0.0 5.3e-43 147.3 0.0 1.5 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.15 EMD61669.1 - 5.6e-29 100.6 0.0 2.5e-28 98.6 0.0 2.2 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region Zn_clus PF00172.18 EMD61671.1 - 2.1e-09 37.3 11.3 3.3e-09 36.7 11.3 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TROVE PF05731.11 EMD61672.1 - 0.1 11.6 0.0 0.1 11.6 0.0 1.0 1 0 0 1 1 1 0 TROVE domain Tim54 PF11711.8 EMD61673.1 - 3.9e-149 496.5 0.1 4.4e-149 496.3 0.1 1.0 1 0 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 Pre-PUA PF17832.1 EMD61674.1 - 2.4e-25 89.0 0.3 3.4e-25 88.6 0.3 1.2 1 0 0 1 1 1 1 Pre-PUA-like domain PUA PF01472.20 EMD61674.1 - 2.8e-15 56.0 0.1 9e-15 54.4 0.1 1.8 1 1 0 1 1 1 1 PUA domain DUF1947 PF09183.10 EMD61674.1 - 0.014 15.7 0.2 0.026 14.8 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1947) GST_N_3 PF13417.6 EMD61675.1 - 4.9e-21 74.9 0.0 1e-20 73.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EMD61675.1 - 1e-16 60.9 0.1 2.5e-16 59.7 0.1 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 EMD61675.1 - 5.5e-08 33.1 0.7 1.2e-07 31.9 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EMD61675.1 - 1.3e-07 31.5 0.1 3.1e-07 30.3 0.1 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_5 PF16865.5 EMD61675.1 - 0.00044 20.8 0.0 0.00075 20.0 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain JAB PF01398.21 EMD61676.1 - 5.4e-05 23.1 0.0 0.00067 19.6 0.0 2.4 1 1 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease UCR_14kD PF02271.16 EMD61676.1 - 0.069 13.1 0.5 7.8 6.5 0.0 2.5 2 0 0 2 2 2 0 Ubiquinol-cytochrome C reductase complex 14kD subunit RPA43_OB PF17875.1 EMD61678.1 - 8.2e-18 65.2 1.3 8.2e-18 65.2 1.3 3.2 3 1 0 3 3 3 1 RPA43 OB domain in RNA Pol I SHS2_Rpb7-N PF03876.17 EMD61678.1 - 4.4e-07 30.2 0.0 7.9e-07 29.4 0.0 1.5 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 DUF423 PF04241.15 EMD61679.1 - 4.5e-23 81.2 2.3 7.1e-23 80.6 2.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF423) p450 PF00067.22 EMD61680.1 - 1.9e-53 181.9 0.0 2.7e-53 181.4 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 zf-C2H2_6 PF13912.6 EMD61682.1 - 5.1e-07 29.5 0.6 0.012 15.5 0.0 2.4 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EMD61682.1 - 1.1e-06 28.8 8.2 1.4e-06 28.4 0.8 3.3 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2 PF00096.26 EMD61682.1 - 3.7e-06 27.1 0.5 3.7e-06 27.1 0.5 3.3 2 1 0 2 2 2 1 Zinc finger, C2H2 type FOXP-CC PF16159.5 EMD61682.1 - 0.00086 19.9 13.0 0.17 12.5 2.7 3.7 3 1 1 4 4 4 2 FOXP coiled-coil domain zf-C2H2_4 PF13894.6 EMD61682.1 - 0.0017 19.1 0.4 0.0017 19.1 0.4 2.9 3 0 0 3 3 3 1 C2H2-type zinc finger zf-C2H2_11 PF16622.5 EMD61682.1 - 0.16 11.7 0.3 0.6 9.9 0.0 1.9 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-C2H2_jaz PF12171.8 EMD61682.1 - 0.2 12.0 0.7 2.1 8.7 0.2 2.5 2 1 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.6 EMD61682.1 - 0.4 10.5 2.9 0.72 9.7 0.1 2.4 2 0 0 2 2 2 0 C2H2-type zinc-finger domain zf-Di19 PF05605.12 EMD61682.1 - 3.7 7.9 5.9 13 6.1 1.5 2.4 1 1 2 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding Aldo_ket_red PF00248.21 EMD61683.1 - 3.3e-72 243.2 0.0 3.7e-72 243.0 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Ceramidase PF05875.12 EMD61684.1 - 3.5e-81 272.5 6.6 4e-81 272.3 6.6 1.0 1 0 0 1 1 1 1 Ceramidase Leader_Trp PF08255.11 EMD61684.1 - 0.02 14.8 2.2 0.084 12.8 2.2 2.1 1 0 0 1 1 1 0 Trp-operon Leader Peptide NCE101 PF11654.8 EMD61684.1 - 0.045 13.5 0.5 0.36 10.6 0.4 2.3 2 0 0 2 2 2 0 Non-classical export protein 1 Sugar_tr PF00083.24 EMD61685.1 - 2.8e-97 326.4 31.6 3.5e-97 326.1 31.6 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD61685.1 - 3.2e-26 92.1 39.2 8.1e-21 74.3 19.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Pannexin_like PF12534.8 EMD61685.1 - 0.072 12.2 0.0 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 Ank_5 PF13857.6 EMD61686.1 - 3.9e-17 62.1 0.2 1.6e-12 47.4 0.0 4.3 3 1 1 4 4 4 2 Ankyrin repeats (many copies) VPS9 PF02204.18 EMD61686.1 - 1.8e-16 60.2 0.1 4.8e-16 58.9 0.1 1.7 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain Ank_2 PF12796.7 EMD61686.1 - 6.9e-15 55.4 0.0 0.00062 20.3 0.0 5.2 5 1 1 6 6 6 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EMD61686.1 - 3.8e-06 26.8 0.0 0.088 13.4 0.0 5.1 4 1 0 4 4 4 1 Ankyrin repeat Ank_4 PF13637.6 EMD61686.1 - 0.00019 21.9 0.0 0.042 14.5 0.0 4.6 4 1 0 4 4 4 1 Ankyrin repeats (many copies) PX PF00787.24 EMD61686.1 - 0.00034 20.6 0.1 0.0019 18.2 0.0 2.3 2 0 0 2 2 2 1 PX domain Ank PF00023.30 EMD61686.1 - 0.0013 19.1 0.4 2.9 8.5 0.0 4.7 5 0 0 5 5 5 1 Ankyrin repeat FAD_binding_4 PF01565.23 EMD61687.1 - 6.2e-22 77.8 1.3 1e-21 77.2 1.3 1.3 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EMD61687.1 - 1.1e-13 51.0 0.1 2.6e-13 49.9 0.1 1.7 1 0 0 1 1 1 1 Berberine and berberine like LRR_4 PF12799.7 EMD61688.1 - 0.02 15.3 2.4 7.5 7.1 0.2 4.3 3 1 1 4 4 4 0 Leucine Rich repeats (2 copies) adh_short PF00106.25 EMD61689.1 - 8.7e-21 74.3 0.0 1.5e-20 73.5 0.0 1.5 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD61689.1 - 5.2e-12 45.8 0.1 1.8e-11 44.0 0.1 1.7 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD61689.1 - 1.8e-07 31.2 0.3 1e-05 25.5 0.3 2.2 1 1 0 1 1 1 1 KR domain THF_DHG_CYH_C PF02882.19 EMD61689.1 - 0.012 14.9 0.0 0.028 13.7 0.0 1.5 2 0 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain ApbA PF02558.16 EMD61689.1 - 0.057 13.1 0.0 0.12 12.0 0.0 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Epimerase PF01370.21 EMD61689.1 - 0.15 11.5 0.0 0.21 11.0 0.0 1.6 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family WSC PF01822.19 EMD61690.1 - 5.5e-16 58.5 6.3 6.5e-16 58.3 6.3 1.1 1 0 0 1 1 1 1 WSC domain Sas10 PF09368.10 EMD61691.1 - 3.1e-29 101.3 9.6 3.1e-29 101.3 9.6 3.2 4 0 0 4 4 4 1 Sas10 C-terminal domain Sas10_Utp3 PF04000.15 EMD61691.1 - 7.4e-12 45.7 1.0 2.7e-11 43.9 0.0 2.6 2 0 0 2 2 2 1 Sas10/Utp3/C1D family BOP1NT PF08145.12 EMD61692.1 - 2.6e-104 348.8 7.4 3.5e-104 348.3 7.4 1.2 1 0 0 1 1 1 1 BOP1NT (NUC169) domain WD40 PF00400.32 EMD61692.1 - 4.1e-21 74.9 0.7 6.5e-07 30.0 0.0 5.0 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD61692.1 - 3.2e-06 27.3 0.3 0.16 12.3 0.0 4.8 2 1 4 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain Nop53 PF07767.11 EMD61692.1 - 0.065 12.6 0.1 0.093 12.1 0.1 1.2 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) DEAD PF00270.29 EMD61693.1 - 5.4e-47 159.8 0.0 2.6e-45 154.4 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EMD61693.1 - 3.5e-26 91.7 0.0 1.2e-25 90.0 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EMD61693.1 - 0.00015 21.8 0.0 0.0012 18.9 0.0 2.4 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 EMD61693.1 - 0.0019 17.6 0.0 0.0081 15.5 0.0 2.0 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit Sld5 PF05916.11 EMD61694.1 - 1.5e-14 54.3 0.0 2.2e-14 53.8 0.0 1.2 1 0 0 1 1 1 1 GINS complex protein HMG_box PF00505.19 EMD61695.1 - 1.2e-08 35.3 0.2 2.6e-08 34.2 0.2 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box DUF4543 PF15076.6 EMD61695.1 - 0.04 14.1 0.1 0.11 12.6 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4543) zf-C2H2_aberr PF17017.5 EMD61696.1 - 0.025 14.7 0.5 0.03 14.5 0.5 1.1 1 0 0 1 1 1 0 Aberrant zinc-finger AflR PF08493.10 EMD61697.1 - 1.3e-09 38.0 19.1 7e-08 32.3 19.1 2.7 1 1 0 1 1 1 1 Aflatoxin regulatory protein Zn_clus PF00172.18 EMD61697.1 - 1.4e-07 31.5 12.0 3.9e-07 30.1 12.0 1.8 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MutS_V PF00488.21 EMD61699.1 - 1.3e-50 172.0 0.0 2.4e-50 171.2 0.0 1.4 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 EMD61699.1 - 2.4e-17 63.8 0.1 4.2e-17 63.0 0.1 1.4 1 0 0 1 1 1 1 MutS domain III MutS_IV PF05190.18 EMD61699.1 - 0.00079 19.7 0.0 0.0028 18.0 0.0 2.0 1 1 1 2 2 2 1 MutS family domain IV DUF1073 PF06381.11 EMD61699.1 - 0.009 14.8 0.1 0.014 14.2 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1073) AAA_2 PF07724.14 EMD61700.1 - 2.5e-47 161.2 0.0 1.9e-45 155.0 0.0 2.6 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 EMD61700.1 - 1.9e-35 120.9 3.6 1.9e-35 120.9 3.6 2.6 1 1 1 2 2 2 1 AAA lid domain ClpB_D2-small PF10431.9 EMD61700.1 - 6e-27 93.5 0.1 2.5e-26 91.5 0.1 2.2 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA PF00004.29 EMD61700.1 - 6.1e-20 72.0 1.3 3.9e-11 43.5 0.0 3.0 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EMD61700.1 - 2.8e-13 50.0 0.0 4.9e-08 33.1 0.0 3.2 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 EMD61700.1 - 3.6e-08 33.3 0.2 0.00011 21.9 0.0 2.6 2 1 0 2 2 2 2 Sigma-54 interaction domain AAA_16 PF13191.6 EMD61700.1 - 2.2e-07 31.4 5.1 0.00082 19.8 0.3 3.9 3 2 0 3 3 2 2 AAA ATPase domain TniB PF05621.11 EMD61700.1 - 5.4e-07 29.2 0.1 0.0025 17.2 0.1 3.5 2 1 0 2 2 2 1 Bacterial TniB protein AAA_22 PF13401.6 EMD61700.1 - 4.9e-06 26.9 5.3 0.037 14.3 0.0 3.9 4 2 0 4 4 3 2 AAA domain AAA_18 PF13238.6 EMD61700.1 - 7.8e-06 26.5 2.6 0.044 14.3 0.0 4.0 4 0 0 4 4 4 2 AAA domain AAA_14 PF13173.6 EMD61700.1 - 1e-05 25.6 0.3 0.21 11.6 0.0 2.8 3 0 0 3 3 2 2 AAA domain AAA_7 PF12775.7 EMD61700.1 - 1.7e-05 24.4 0.0 0.16 11.4 0.0 2.6 2 1 0 2 2 2 2 P-loop containing dynein motor region NACHT PF05729.12 EMD61700.1 - 5.8e-05 23.1 0.0 0.059 13.3 0.0 2.6 2 0 0 2 2 2 1 NACHT domain ATPase_2 PF01637.18 EMD61700.1 - 0.00013 22.0 9.0 0.2 11.5 0.5 4.3 3 1 0 3 3 3 1 ATPase domain predominantly from Archaea IstB_IS21 PF01695.17 EMD61700.1 - 0.0004 20.2 0.3 0.4 10.4 0.0 3.0 3 0 0 3 3 2 1 IstB-like ATP binding protein SRP54 PF00448.22 EMD61700.1 - 0.00055 19.6 0.1 0.055 13.1 0.0 2.5 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain RNA_helicase PF00910.22 EMD61700.1 - 0.00097 19.5 0.1 0.95 9.9 0.0 3.0 3 0 0 3 3 2 1 RNA helicase Roc PF08477.13 EMD61700.1 - 0.0013 18.9 0.0 0.81 9.9 0.0 2.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase ResIII PF04851.15 EMD61700.1 - 0.0014 18.7 0.0 0.87 9.6 0.0 3.3 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit Mg_chelatase PF01078.21 EMD61700.1 - 0.0015 17.9 0.4 1 8.7 0.0 3.3 2 2 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_30 PF13604.6 EMD61700.1 - 0.0023 17.7 3.4 0.14 11.9 0.0 3.7 4 0 0 4 4 3 1 AAA domain AAA_19 PF13245.6 EMD61700.1 - 0.004 17.5 0.2 0.54 10.6 0.1 3.0 4 0 0 4 4 2 1 AAA domain TsaE PF02367.17 EMD61700.1 - 0.0063 16.5 0.0 3.9 7.5 0.0 2.7 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_24 PF13479.6 EMD61700.1 - 0.0091 15.7 0.0 5.7 6.6 0.0 2.4 2 0 0 2 2 2 0 AAA domain TrwB_AAD_bind PF10412.9 EMD61700.1 - 0.011 14.7 0.1 3.5 6.4 0.1 2.7 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain DUF815 PF05673.13 EMD61700.1 - 0.012 14.8 0.3 0.44 9.7 0.2 3.2 3 1 0 3 3 2 0 Protein of unknown function (DUF815) AAA_33 PF13671.6 EMD61700.1 - 0.023 14.9 2.6 3.1 8.0 0.0 3.2 3 0 0 3 3 2 0 AAA domain PduV-EutP PF10662.9 EMD61700.1 - 0.032 14.0 0.0 3.1 7.5 0.0 2.6 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation RsgA_GTPase PF03193.16 EMD61700.1 - 0.045 13.7 2.0 8.3 6.3 0.0 3.0 3 0 0 3 3 3 0 RsgA GTPase ABC_tran PF00005.27 EMD61700.1 - 0.055 14.0 2.9 19 5.8 0.0 3.3 3 0 0 3 3 3 0 ABC transporter AAA_6 PF12774.7 EMD61700.1 - 0.065 12.2 0.0 1.1 8.2 0.0 2.2 2 0 0 2 2 2 0 Hydrolytic ATP binding site of dynein motor region ATP_bind_1 PF03029.17 EMD61700.1 - 0.11 12.2 0.0 1.9 8.2 0.0 2.5 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_28 PF13521.6 EMD61700.1 - 0.14 12.4 8.6 1.4 9.2 0.0 4.0 5 1 1 6 6 3 0 AAA domain GAS PF13851.6 EMD61700.1 - 0.19 11.0 16.0 0.49 9.7 16.0 1.6 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding OEP PF02321.18 EMD61700.1 - 0.22 11.3 16.6 0.43 10.4 16.6 1.4 1 0 0 1 1 1 0 Outer membrane efflux protein NTPase_1 PF03266.15 EMD61700.1 - 0.28 11.1 2.1 3.6 7.5 0.0 3.0 3 0 0 3 3 3 0 NTPase AAA_15 PF13175.6 EMD61700.1 - 0.28 10.8 3.1 12 5.5 1.5 2.1 2 0 0 2 2 2 0 AAA ATPase domain GBP_C PF02841.14 EMD61700.1 - 0.53 9.7 12.4 0.87 8.9 12.4 1.3 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain V_ATPase_I PF01496.19 EMD61700.1 - 0.66 7.8 5.0 0.89 7.4 5.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4407 PF14362.6 EMD61700.1 - 1.3 8.3 8.7 2.2 7.5 8.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF87 PF01935.17 EMD61700.1 - 1.4 9.0 6.0 28 4.7 0.0 3.7 4 0 0 4 4 4 0 Helicase HerA, central domain DivIC PF04977.15 EMD61700.1 - 2.2 8.1 18.2 0.98 9.2 9.0 2.6 1 1 1 2 2 2 0 Septum formation initiator DUF1640 PF07798.11 EMD61700.1 - 3 7.9 11.1 6 6.9 11.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1640) DUF4446 PF14584.6 EMD61700.1 - 4.2 7.3 5.3 10 6.1 5.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) Atg14 PF10186.9 EMD61700.1 - 5.6 6.0 10.2 10 5.1 10.2 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 PTPlike_phytase PF14566.6 EMD61700.1 - 6.4 6.9 6.8 4.9 7.3 5.0 1.7 2 0 0 2 2 1 0 Inositol hexakisphosphate EF1_GNE PF00736.19 EMD61701.1 - 2.3e-32 111.0 3.3 4.9e-32 110.0 3.3 1.6 1 0 0 1 1 1 1 EF-1 guanine nucleotide exchange domain EF-1_beta_acid PF10587.9 EMD61701.1 - 2.1e-14 53.7 8.9 5.7e-14 52.3 8.9 1.8 1 0 0 1 1 1 1 Eukaryotic elongation factor 1 beta central acidic region DUF211 PF02680.14 EMD61701.1 - 0.032 14.4 0.8 0.052 13.7 0.8 1.5 1 1 0 1 1 1 0 Uncharacterized ArCR, COG1888 GST_C_3 PF14497.6 EMD61701.1 - 0.092 12.9 0.3 0.4 10.9 0.0 2.0 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain DUF5345 PF17280.2 EMD61702.1 - 0.098 12.6 0.3 0.098 12.6 0.3 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5345) Ost5 PF05251.12 EMD61702.1 - 0.17 12.2 0.4 0.17 12.2 0.4 2.8 4 0 0 4 4 4 0 Oligosaccharyltransferase subunit 5 PGG PF13962.6 EMD61702.1 - 4.1 7.3 11.3 4.5 7.1 1.0 3.0 2 1 1 3 3 3 0 Domain of unknown function PNP_UDP_1 PF01048.20 EMD61703.1 - 1.6e-18 66.8 0.5 2.7e-17 62.8 0.5 2.3 1 1 0 1 1 1 1 Phosphorylase superfamily Hira PF07569.11 EMD61704.1 - 9.3e-78 261.0 0.0 3.6e-77 259.1 0.0 2.0 2 0 0 2 2 2 1 TUP1-like enhancer of split WD40 PF00400.32 EMD61704.1 - 4.9e-30 103.1 19.3 2.9e-05 24.7 0.0 9.0 7 1 1 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD61704.1 - 1.1e-14 54.4 0.0 0.0027 17.9 0.0 6.2 4 2 3 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain HIRA_B PF09453.10 EMD61704.1 - 2.1e-11 43.4 1.3 5.2e-11 42.1 1.3 1.8 1 0 0 1 1 1 1 HIRA B motif PD40 PF07676.12 EMD61704.1 - 3.4e-05 23.7 0.3 5.2 7.1 0.1 5.0 5 0 0 5 5 5 2 WD40-like Beta Propeller Repeat Ge1_WD40 PF16529.5 EMD61704.1 - 0.00016 20.7 1.9 0.22 10.4 0.0 4.3 2 2 3 5 5 5 1 WD40 region of Ge1, enhancer of mRNA-decapping protein IKI3 PF04762.12 EMD61704.1 - 0.0058 14.7 0.3 0.065 11.2 0.0 2.2 3 0 0 3 3 3 1 IKI3 family Mucin PF01456.17 EMD61704.1 - 0.037 14.0 13.0 0.096 12.7 13.0 1.7 1 0 0 1 1 1 0 Mucin-like glycoprotein DUF3439 PF11921.8 EMD61704.1 - 7.6 6.5 9.3 17 5.4 9.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) zf-U1 PF06220.12 EMD61705.1 - 1.7e-08 34.1 0.2 2.6e-08 33.5 0.2 1.3 1 0 0 1 1 1 1 U1 zinc finger MFS_1 PF07690.16 EMD61706.1 - 1.7e-47 162.0 34.8 1.7e-47 162.0 34.8 1.6 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EMD61706.1 - 7.3e-09 35.0 23.7 1.3e-08 34.2 23.7 1.5 1 1 0 1 1 1 1 Sugar (and other) transporter OATP PF03137.20 EMD61706.1 - 0.059 11.6 16.9 0.0045 15.3 7.8 3.0 2 1 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family HLH PF00010.26 EMD61707.1 - 1.2e-13 50.8 0.4 2e-13 50.1 0.4 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Podoplanin PF05808.11 EMD61710.1 - 0.043 13.9 0.9 0.055 13.6 0.9 1.1 1 0 0 1 1 1 0 Podoplanin Methyltransf_12 PF08242.12 EMD61710.1 - 0.15 12.8 0.0 0.19 12.5 0.0 1.1 1 0 0 1 1 1 0 Methyltransferase domain IBN_N PF03810.19 EMD61712.1 - 4.3e-09 36.2 1.5 7.5e-08 32.2 0.1 3.6 4 0 0 4 4 4 1 Importin-beta N-terminal domain Xpo1 PF08389.12 EMD61712.1 - 2.7e-05 24.3 0.1 0.003 17.6 0.0 3.0 2 0 0 2 2 2 1 Exportin 1-like protein Proteasom_PSMB PF10508.9 EMD61712.1 - 0.059 11.9 0.0 7.1 5.0 0.0 2.6 2 0 0 2 2 2 0 Proteasome non-ATPase 26S subunit PHB_acc PF05233.13 EMD61712.1 - 0.12 12.4 0.0 6.3 6.9 0.0 2.9 3 0 0 3 3 3 0 PHB accumulation regulatory domain HORMA PF02301.18 EMD61713.1 - 7.2e-11 42.1 0.0 9.8e-11 41.6 0.0 1.1 1 0 0 1 1 1 1 HORMA domain Acetyltransf_9 PF13527.7 EMD61714.1 - 0.0018 18.4 0.1 0.0097 16.0 0.0 2.1 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EMD61714.1 - 0.16 11.9 0.0 0.47 10.4 0.0 1.7 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain IBR PF01485.21 EMD61715.1 - 0.00018 21.7 7.8 0.00018 21.7 7.8 3.4 2 1 0 2 2 2 1 IBR domain, a half RING-finger domain Thr_synth_N PF14821.6 EMD61716.1 - 8.5e-30 102.8 0.0 2.1e-29 101.6 0.0 1.7 1 0 0 1 1 1 1 Threonine synthase N terminus PALP PF00291.25 EMD61716.1 - 1.5e-18 67.3 0.0 8e-18 64.9 0.0 1.8 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme NAD_binding_2 PF03446.15 EMD61717.1 - 6.5e-26 91.4 0.0 9.7e-26 90.8 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 EMD61717.1 - 1e-05 25.8 0.0 2e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase F420_oxidored PF03807.17 EMD61717.1 - 2.3e-05 24.9 0.0 8e-05 23.1 0.0 2.0 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.20 EMD61717.1 - 0.064 13.3 0.0 0.1 12.6 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Leo1 PF04004.13 EMD61718.1 - 2.2e-41 141.5 0.3 4.7e-41 140.4 0.3 1.6 1 0 0 1 1 1 1 Leo1-like protein Mob1_phocein PF03637.17 EMD61719.1 - 1.9e-42 145.2 0.0 6e-42 143.5 0.0 1.7 1 1 0 1 1 1 1 Mob1/phocein family Arf PF00025.21 EMD61720.1 - 6.7e-80 266.6 0.2 7.7e-80 266.4 0.2 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EMD61720.1 - 2.5e-14 53.5 0.0 3.6e-14 53.0 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EMD61720.1 - 3.7e-14 52.5 0.0 4.6e-14 52.3 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 EMD61720.1 - 1.7e-13 50.5 1.2 1.6e-09 37.4 0.2 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 EMD61720.1 - 8.8e-13 48.2 0.0 9.5e-13 48.1 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 EMD61720.1 - 1.7e-10 40.7 0.0 2.1e-10 40.4 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EMD61720.1 - 5.1e-06 26.6 0.0 7.8e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.18 EMD61720.1 - 0.0085 15.4 0.4 0.027 13.8 0.1 1.7 1 1 0 2 2 2 1 6-phosphofructo-2-kinase MAPEG PF01124.18 EMD61721.1 - 0.037 13.9 12.1 0.12 12.2 12.1 1.9 1 1 0 1 1 1 0 MAPEG family p450 PF00067.22 EMD61722.1 - 3.6e-61 207.3 0.0 4.7e-61 206.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 FAA_hydrolase PF01557.18 EMD61723.1 - 1.6e-51 175.1 0.0 2.3e-51 174.5 0.0 1.2 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family FAA_hydrolase_N PF09298.11 EMD61723.1 - 6.8e-33 113.1 0.0 1.1e-32 112.3 0.0 1.4 1 0 0 1 1 1 1 Fumarylacetoacetase N-terminal E1_FCCH PF16190.5 EMD61723.1 - 0.13 12.5 0.1 0.41 10.9 0.1 1.8 1 0 0 1 1 1 0 Ubiquitin-activating enzyme E1 FCCH domain HgmA PF04209.13 EMD61724.1 - 1.4e-201 669.8 0.1 1.6e-201 669.6 0.1 1.0 1 0 0 1 1 1 1 homogentisate 1,2-dioxygenase AdoHcyase PF05221.17 EMD61725.1 - 4.3e-128 426.7 0.0 1.7e-73 247.4 0.1 2.0 1 1 1 2 2 2 2 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.21 EMD61725.1 - 2.5e-83 278.0 1.8 3.8e-83 277.4 1.8 1.3 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.19 EMD61725.1 - 1.2e-07 31.3 0.1 2.8e-07 30.1 0.1 1.6 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ELFV_dehydrog PF00208.21 EMD61725.1 - 0.0013 18.6 0.1 0.0022 17.8 0.1 1.4 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase IlvN PF07991.12 EMD61725.1 - 0.0023 17.5 0.2 0.004 16.7 0.2 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain TrkA_N PF02254.18 EMD61725.1 - 0.0099 16.1 0.0 0.019 15.2 0.0 1.5 1 0 0 1 1 1 1 TrkA-N domain 3HCDH_N PF02737.18 EMD61725.1 - 0.059 13.3 0.2 0.11 12.4 0.2 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain TMEM107 PF14995.6 EMD61725.1 - 0.062 13.7 0.0 0.12 12.9 0.0 1.4 1 0 0 1 1 1 0 Transmembrane protein HET PF06985.11 EMD61726.1 - 5e-41 140.5 1.7 7e-41 140.0 1.7 1.2 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Ank_4 PF13637.6 EMD61727.1 - 4.8e-29 100.3 0.6 4.1e-10 40.0 0.0 3.0 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 EMD61727.1 - 1.4e-26 92.9 2.3 6.3e-17 61.9 0.2 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 EMD61727.1 - 1.3e-22 79.1 0.5 1.2e-05 25.5 0.0 4.0 4 0 0 4 4 4 4 Ankyrin repeat Ank_3 PF13606.6 EMD61727.1 - 8.8e-16 56.4 0.1 0.012 16.0 0.0 4.1 4 0 0 4 4 4 4 Ankyrin repeat Ank_5 PF13857.6 EMD61727.1 - 8.6e-13 48.2 4.7 1.7e-07 31.3 0.3 2.9 1 1 2 3 3 3 3 Ankyrin repeats (many copies) DUF4350 PF14258.6 EMD61727.1 - 0.0032 17.8 0.7 4 7.9 0.1 3.0 2 2 0 2 2 2 2 Domain of unknown function (DUF4350) VWA_3_C PF18571.1 EMD61727.1 - 4.4 7.3 6.8 45 4.0 0.1 3.5 4 0 0 4 4 4 0 von Willebrand factor type A C-terminal domain ABC_tran PF00005.27 EMD61728.1 - 4.3e-46 156.8 0.6 1.7e-21 77.2 0.0 2.9 3 0 0 3 3 2 2 ABC transporter ABC_tran_Xtn PF12848.7 EMD61728.1 - 5.1e-21 74.5 5.5 5.1e-21 74.5 5.5 3.5 5 0 0 5 5 4 1 ABC transporter AAA_21 PF13304.6 EMD61728.1 - 9.7e-17 61.7 4.7 0.00043 20.2 0.0 4.6 2 2 1 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EMD61728.1 - 4.8e-10 39.2 0.7 0.017 14.5 0.0 4.1 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EMD61728.1 - 2.8e-06 28.0 11.8 0.017 15.6 0.0 4.8 5 0 0 5 5 5 2 AAA domain AAA_22 PF13401.6 EMD61728.1 - 2.1e-05 24.8 0.0 0.16 12.2 0.0 2.8 2 0 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 EMD61728.1 - 2.9e-05 24.0 0.0 0.12 12.2 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EMD61728.1 - 4.7e-05 23.4 0.0 0.096 12.8 0.0 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_33 PF13671.6 EMD61728.1 - 6.8e-05 23.0 0.1 0.36 11.0 0.0 2.9 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.6 EMD61728.1 - 8.5e-05 22.2 0.3 0.29 10.9 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_18 PF13238.6 EMD61728.1 - 8.7e-05 23.1 0.1 1.1 9.8 0.0 3.6 3 0 0 3 3 3 2 AAA domain AAA_30 PF13604.6 EMD61728.1 - 9.6e-05 22.2 0.6 0.012 15.3 0.0 3.0 3 0 0 3 3 3 1 AAA domain AAA_24 PF13479.6 EMD61728.1 - 0.00031 20.5 0.0 0.78 9.4 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EMD61728.1 - 0.00041 20.8 2.7 0.036 14.4 0.3 2.9 3 0 0 3 3 2 1 AAA ATPase domain AAA_28 PF13521.6 EMD61728.1 - 0.0014 18.9 2.4 0.15 12.3 0.1 2.8 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 EMD61728.1 - 0.0016 18.9 0.0 3.7 8.0 0.1 2.8 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 EMD61728.1 - 0.002 18.0 0.2 0.64 9.9 0.0 2.5 2 0 0 2 2 2 1 NACHT domain AAA_14 PF13173.6 EMD61728.1 - 0.0074 16.3 0.0 3.8 7.6 0.0 2.8 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 EMD61728.1 - 0.012 16.0 0.0 7.9 6.9 0.0 2.6 2 0 0 2 2 2 0 RNA helicase AAA_27 PF13514.6 EMD61728.1 - 0.014 15.0 0.4 5.9 6.4 0.0 2.9 3 0 0 3 3 2 0 AAA domain Zeta_toxin PF06414.12 EMD61728.1 - 0.05 12.9 0.1 8.7 5.6 0.1 2.6 2 0 0 2 2 2 0 Zeta toxin AAA_15 PF13175.6 EMD61728.1 - 0.055 13.2 11.7 0.63 9.7 0.0 4.1 4 1 0 4 4 3 0 AAA ATPase domain MeaB PF03308.16 EMD61728.1 - 0.061 12.3 0.4 6.2 5.7 0.0 2.6 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB NTPase_1 PF03266.15 EMD61728.1 - 0.066 13.1 0.0 3.3 7.6 0.0 2.5 2 0 0 2 2 2 0 NTPase TsaE PF02367.17 EMD61728.1 - 0.075 13.0 0.0 17 5.4 0.0 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE cobW PF02492.19 EMD61728.1 - 0.09 12.4 0.5 7.4 6.1 0.4 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_5 PF07728.14 EMD61728.1 - 0.1 12.6 0.2 11 6.0 0.0 3.0 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) Dynamin_N PF00350.23 EMD61728.1 - 0.11 12.6 0.2 4.5 7.3 0.0 3.1 3 0 0 3 3 3 0 Dynamin family SRP54 PF00448.22 EMD61728.1 - 0.11 12.1 0.4 8.6 5.9 0.2 2.6 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain MobB PF03205.14 EMD61728.1 - 0.14 12.1 0.1 3.6 7.5 0.1 2.5 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B Nicastrin PF05450.15 EMD61729.1 - 0.01 15.3 0.1 0.015 14.8 0.1 1.3 1 0 0 1 1 1 0 Nicastrin SGL PF08450.12 EMD61731.1 - 0.00015 21.4 0.1 0.0048 16.5 0.0 2.6 2 1 0 2 2 2 1 SMP-30/Gluconolactonase/LRE-like region PD40 PF07676.12 EMD61731.1 - 0.065 13.2 0.1 0.44 10.6 0.0 2.4 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat Ribosomal_L23 PF00276.20 EMD61735.1 - 9.4e-07 29.1 0.0 2e-06 28.0 0.0 1.6 1 0 0 1 1 1 1 Ribosomal protein L23 HeLo PF14479.6 EMD61735.1 - 0.63 9.9 5.4 0.87 9.4 5.4 1.1 1 0 0 1 1 1 0 Prion-inhibition and propagation Fungal_trans PF04082.18 EMD61737.1 - 1.3e-10 40.7 0.2 3.9e-10 39.2 0.0 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain 2-Hacid_dh_C PF02826.19 EMD61738.1 - 4.8e-47 159.6 0.0 7.1e-47 159.0 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EMD61738.1 - 2.6e-17 62.7 0.0 3.9e-17 62.2 0.0 1.3 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 EMD61738.1 - 0.00056 20.1 0.0 0.0011 19.2 0.0 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase AdoHcyase_NAD PF00670.21 EMD61738.1 - 0.0077 16.3 0.0 0.014 15.4 0.0 1.4 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Fungal_trans PF04082.18 EMD61739.1 - 1.7e-12 46.9 0.1 3.1e-12 46.1 0.1 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain HpcH_HpaI PF03328.14 EMD61740.1 - 4.1e-31 107.8 0.0 6.4e-31 107.2 0.0 1.2 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family PEP-utilizers_C PF02896.18 EMD61740.1 - 0.008 15.3 0.2 0.061 12.4 0.2 2.4 1 1 0 1 1 1 1 PEP-utilising enzyme, TIM barrel domain DUF3357 PF11837.8 EMD61740.1 - 0.036 14.5 0.4 0.068 13.6 0.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3357) MFS_1 PF07690.16 EMD61741.1 - 9.6e-31 107.0 26.8 9.6e-31 107.0 26.8 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily MFS_4 PF06779.14 EMD61741.1 - 1e-07 31.6 2.8 2.5e-07 30.3 2.8 1.6 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB PUCC PF03209.15 EMD61741.1 - 0.0042 16.2 4.1 0.0085 15.1 4.1 1.5 1 0 0 1 1 1 1 PUCC protein PepSY_TM_like_2 PF16357.5 EMD61741.1 - 0.03 14.3 0.6 0.03 14.3 0.6 1.8 2 0 0 2 2 2 0 Putative PepSY_TM-like DUF1478 PF07349.11 EMD61741.1 - 0.044 13.7 0.4 0.044 13.7 0.4 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1478) Prefoldin PF02996.17 EMD61743.1 - 7e-24 84.0 0.0 9.1e-24 83.7 0.0 1.1 1 0 0 1 1 1 1 Prefoldin subunit Prefoldin_2 PF01920.20 EMD61743.1 - 0.011 15.7 0.5 4.5 7.3 0.1 2.1 2 0 0 2 2 2 0 Prefoldin subunit DUF4164 PF13747.6 EMD61743.1 - 0.038 14.3 0.1 3.5 8.0 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4164) Mating_N PF12731.7 EMD61743.1 - 0.062 13.4 0.7 0.11 12.6 0.7 1.3 1 0 0 1 1 1 0 Mating-type protein beta 1 Baculo_PEP_C PF04513.12 EMD61743.1 - 0.074 13.1 0.2 0.34 11.0 0.1 1.8 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Fib_alpha PF08702.10 EMD61743.1 - 0.1 12.8 0.7 11 6.2 0.0 2.1 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Phage_TAC_11 PF11836.8 EMD61743.1 - 0.12 12.5 0.0 1.5 9.0 0.0 2.0 2 0 0 2 2 2 0 Phage tail tube protein, GTA-gp10 CRC_subunit PF08624.10 EMD61746.1 - 8.1e-52 175.2 0.0 1.2e-51 174.7 0.0 1.2 1 0 0 1 1 1 1 Chromatin remodelling complex Rsc7/Swp82 subunit SF3A2 PF16835.5 EMD61748.1 - 8.2e-35 119.1 0.0 1.3e-34 118.4 0.0 1.3 1 0 0 1 1 1 1 Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) zf-met PF12874.7 EMD61748.1 - 2e-05 24.8 0.5 2e-05 24.8 0.5 1.9 2 0 0 2 2 2 1 Zinc-finger of C2H2 type PRP4 PF08799.11 EMD61748.1 - 0.053 13.1 1.5 0.11 12.1 1.5 1.6 1 0 0 1 1 1 0 pre-mRNA processing factor 4 (PRP4) like CAP_GLY PF01302.25 EMD61749.1 - 8.1e-19 67.4 0.0 1.3e-18 66.7 0.0 1.3 1 0 0 1 1 1 1 CAP-Gly domain LRR_4 PF12799.7 EMD61749.1 - 1.2e-11 44.7 5.1 0.0035 17.7 1.2 4.7 4 1 0 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EMD61749.1 - 1.4e-06 28.0 5.8 0.012 15.4 0.1 3.9 3 1 1 4 4 4 2 Leucine rich repeat LRR_9 PF14580.6 EMD61749.1 - 0.00053 19.5 0.8 0.028 13.9 0.4 2.5 1 1 1 2 2 2 2 Leucine-rich repeat LRR_6 PF13516.6 EMD61749.1 - 0.0015 18.4 3.6 4.6 7.5 0.0 5.3 5 0 0 5 5 5 1 Leucine Rich repeat Cupin_8 PF13621.6 EMD61750.1 - 5.9e-29 101.5 0.0 8.3e-29 101.1 0.0 1.2 1 0 0 1 1 1 1 Cupin-like domain JmjC PF02373.22 EMD61750.1 - 1.6e-07 31.8 0.0 5.9e-07 29.9 0.0 2.0 2 1 0 2 2 2 1 JmjC domain, hydroxylase Cupin_4 PF08007.12 EMD61750.1 - 0.00079 19.0 0.0 0.0018 17.8 0.0 1.5 2 0 0 2 2 2 1 Cupin superfamily protein Cupin_2 PF07883.11 EMD61750.1 - 0.0012 18.5 0.0 0.0071 16.0 0.0 2.1 2 0 0 2 2 2 1 Cupin domain V-ATPase_H_N PF03224.14 EMD61751.1 - 2.3e-81 273.5 0.2 3.8e-81 272.8 0.2 1.3 1 0 0 1 1 1 1 V-ATPase subunit H V-ATPase_H_C PF11698.8 EMD61751.1 - 1.8e-36 124.8 0.1 9.9e-36 122.4 0.0 2.3 2 0 0 2 2 2 1 V-ATPase subunit H RNB PF00773.19 EMD61752.1 - 2.7e-99 332.6 1.2 5.2e-99 331.7 1.2 1.5 1 0 0 1 1 1 1 RNB domain Rrp44_S1 PF17215.3 EMD61752.1 - 9.2e-31 105.7 0.3 2.8e-30 104.1 0.3 1.9 1 0 0 1 1 1 1 S1 domain Rrp44_CSD1 PF17216.3 EMD61752.1 - 3.6e-29 101.4 0.1 1e-28 99.9 0.1 1.8 1 1 0 1 1 1 1 Rrp44-like cold shock domain OB_Dis3 PF17849.1 EMD61752.1 - 3.4e-21 75.1 0.0 1.1e-20 73.5 0.0 1.9 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) CSD2 PF17876.1 EMD61752.1 - 5e-10 39.4 0.1 8.9e-06 25.8 0.0 3.1 2 1 1 3 3 3 2 Cold shock domain PIN_4 PF13638.6 EMD61752.1 - 1.2e-08 35.3 0.5 4.1e-07 30.3 0.1 2.9 2 0 0 2 2 2 1 PIN domain Dis3l2_C_term PF17877.1 EMD61752.1 - 0.0068 16.7 0.0 0.029 14.7 0.0 2.2 1 0 0 1 1 1 1 DIS3-like exonuclease 2 C terminal CcmD PF04995.14 EMD61753.1 - 0.14 12.3 2.0 0.25 11.5 2.0 1.4 1 0 0 1 1 1 0 Heme exporter protein D (CcmD) Apq12 PF12716.7 EMD61754.1 - 4.6e-21 74.5 10.5 6.7e-21 74.0 10.5 1.3 1 0 0 1 1 1 1 Nuclear pore assembly and biogenesis DUF4131 PF13567.6 EMD61754.1 - 0.036 13.7 0.1 0.05 13.3 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) ESCRT-II PF05871.12 EMD61756.1 - 6.9e-50 168.9 0.0 8.5e-50 168.6 0.0 1.1 1 0 0 1 1 1 1 ESCRT-II complex subunit PPR PF01535.20 EMD61756.1 - 0.15 12.4 0.0 0.39 11.1 0.0 1.8 1 0 0 1 1 1 0 PPR repeat SH3_9 PF14604.6 EMD61757.1 - 0.00013 21.8 0.1 0.00024 20.9 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EMD61757.1 - 0.00053 19.6 0.4 0.001 18.7 0.4 1.4 1 0 0 1 1 1 1 SH3 domain Podoplanin PF05808.11 EMD61757.1 - 0.002 18.3 0.0 0.0045 17.1 0.0 1.6 1 0 0 1 1 1 1 Podoplanin CYYR1 PF10873.8 EMD61757.1 - 0.0021 18.5 0.1 0.0059 17.1 0.1 1.7 1 0 0 1 1 1 1 Cysteine and tyrosine-rich protein 1 CD34_antigen PF06365.12 EMD61757.1 - 0.0026 17.4 0.0 0.0044 16.6 0.0 1.3 1 0 0 1 1 1 1 CD34/Podocalyxin family DUF4690 PF15756.5 EMD61757.1 - 0.0032 18.0 2.3 0.0077 16.8 1.7 2.0 1 1 0 1 1 1 1 Small Novel Rich in Cartilage DAP10 PF07213.11 EMD61757.1 - 0.033 14.1 5.8 0.25 11.3 0.3 2.6 2 0 0 2 2 2 0 DAP10 membrane protein zf-H2C2_2 PF13465.6 EMD61758.1 - 9e-08 32.2 14.7 2.2e-05 24.7 0.7 7.1 7 0 0 7 7 7 4 Zinc-finger double domain zf-C2H2 PF00096.26 EMD61758.1 - 0.0015 18.9 65.7 0.015 15.7 1.2 8.8 9 1 0 9 9 9 6 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 EMD61758.1 - 0.048 14.0 0.8 0.048 14.0 0.8 5.5 5 0 0 5 5 5 0 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 EMD61758.1 - 0.4 11.7 0.2 0.4 11.7 0.2 8.8 7 1 0 7 7 7 0 C2H2-type zinc finger zf-met PF12874.7 EMD61758.1 - 3.2 8.3 15.0 8.4 6.9 0.4 4.4 3 0 0 3 3 3 0 Zinc-finger of C2H2 type PPR_2 PF13041.6 EMD61760.1 - 8.7e-42 141.1 4.3 9.9e-09 35.3 0.0 13.1 11 4 4 15 15 15 8 PPR repeat family PPR_3 PF13812.6 EMD61760.1 - 5.9e-36 122.4 0.1 0.0012 18.8 0.0 11.0 9 2 2 11 11 11 8 Pentatricopeptide repeat domain PPR PF01535.20 EMD61760.1 - 2.9e-23 80.4 16.2 0.00066 19.8 0.0 13.4 17 0 0 17 17 17 4 PPR repeat PPR_1 PF12854.7 EMD61760.1 - 5.9e-21 73.9 1.4 1.3e-06 28.0 0.0 10.8 13 0 0 13 13 13 4 PPR repeat PPR_long PF17177.4 EMD61760.1 - 1.3e-19 70.4 10.8 1.2e-07 31.3 0.1 6.2 4 1 2 6 6 6 4 Pentacotripeptide-repeat region of PRORP RPM2 PF08579.11 EMD61760.1 - 1.8e-05 25.1 0.1 0.0006 20.2 0.0 2.9 2 0 0 2 2 2 1 Mitochondrial ribonuclease P subunit (RPM2) ECSIT PF06239.11 EMD61760.1 - 0.016 14.3 0.7 11 5.1 0.0 4.0 5 0 0 5 5 5 0 Evolutionarily conserved signalling intermediate in Toll pathway GHMP_kinases_N PF00288.26 EMD61761.1 - 7.2e-15 55.0 0.2 4e-14 52.6 0.3 2.1 2 0 0 2 2 2 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 EMD61761.1 - 1.8e-08 34.6 0.0 3.9e-08 33.5 0.0 1.6 1 0 0 1 1 1 1 GHMP kinases C terminal RPN13_C PF16550.5 EMD61761.1 - 0.008 16.3 0.0 0.032 14.4 0.0 2.0 1 0 0 1 1 1 1 UCH-binding domain Ribosomal_L29 PF00831.23 EMD61762.1 - 8.8e-17 60.8 3.6 1.7e-16 59.9 0.2 2.1 2 0 0 2 2 2 1 Ribosomal L29 protein V-SNARE_C PF12352.8 EMD61763.1 - 1.8e-14 53.7 0.2 1.8e-14 53.7 0.2 3.7 4 0 0 4 4 4 1 Snare region anchored in the vesicle membrane C-terminus APG6_N PF17675.1 EMD61763.1 - 0.084 13.4 8.8 0.28 11.7 6.1 2.1 2 0 0 2 2 2 0 Apg6 coiled-coil region Syntaxin-6_N PF09177.11 EMD61763.1 - 0.14 12.7 3.6 0.15 12.7 1.3 2.1 1 1 1 2 2 2 0 Syntaxin 6, N-terminal Not3 PF04065.15 EMD61763.1 - 0.15 11.5 3.9 0.23 10.9 2.7 1.7 1 1 0 1 1 1 0 Not1 N-terminal domain, CCR4-Not complex component DUF4570 PF15134.6 EMD61763.1 - 0.28 11.2 6.5 0.52 10.3 6.1 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4570) Spc7 PF08317.11 EMD61763.1 - 2.1 7.2 8.5 0.45 9.4 5.3 1.6 2 0 0 2 2 2 0 Spc7 kinetochore protein ATP-synt_10 PF05176.14 EMD61764.1 - 5.3e-81 271.6 0.0 7e-81 271.2 0.0 1.1 1 0 0 1 1 1 1 ATP10 protein COesterase PF00135.28 EMD61765.1 - 3.2e-85 287.0 0.0 4.6e-85 286.4 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EMD61765.1 - 2.2e-08 34.3 0.0 3.2e-07 30.4 0.0 2.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EMD61765.1 - 0.00059 19.4 0.1 0.001 18.6 0.1 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family DNA_pol_B_palm PF14792.6 EMD61766.1 - 2.6e-32 111.4 0.0 6.3e-32 110.2 0.0 1.7 1 0 0 1 1 1 1 DNA polymerase beta palm DNA_pol_B_thumb PF14791.6 EMD61766.1 - 1.9e-24 85.6 0.1 3.9e-24 84.6 0.1 1.6 1 0 0 1 1 1 1 DNA polymerase beta thumb DNA_pol_lambd_f PF10391.9 EMD61766.1 - 1.2e-18 66.7 0.9 3.4e-18 65.2 0.0 2.3 3 0 0 3 3 3 1 Fingers domain of DNA polymerase lambda HHH_8 PF14716.6 EMD61766.1 - 4.2e-17 62.3 1.1 8.4e-17 61.3 0.1 2.1 2 0 0 2 2 2 1 Helix-hairpin-helix domain MFS_1 PF07690.16 EMD61767.1 - 1.1e-23 83.8 37.8 1.1e-23 83.8 37.8 2.7 1 1 1 2 2 2 1 Major Facilitator Superfamily Bac_export_2 PF01312.19 EMD61767.1 - 7.3 5.7 8.7 0.15 11.2 0.3 2.4 2 1 0 3 3 3 0 FlhB HrpN YscU SpaS Family DDE_1 PF03184.19 EMD61768.1 - 6.6e-10 38.9 0.0 6.6e-10 38.9 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.6 EMD61768.1 - 0.041 13.7 0.1 0.05 13.4 0.1 1.1 1 0 0 1 1 1 0 DDE superfamily endonuclease DDE_3 PF13358.6 EMD61772.1 - 3.7e-32 111.1 0.0 5.9e-32 110.4 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_33 PF13592.6 EMD61772.1 - 1.7e-06 27.5 0.4 9.9e-06 25.1 0.2 2.3 2 0 0 2 2 2 1 Winged helix-turn helix rve PF00665.26 EMD61772.1 - 2.7e-06 27.5 0.1 5.6e-05 23.3 0.0 2.4 3 0 0 3 3 3 1 Integrase core domain DDE_1 PF03184.19 EMD61772.1 - 5e-06 26.3 0.0 7.7e-06 25.7 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Aldo_ket_red PF00248.21 EMD61775.1 - 4.4e-63 213.2 0.1 5.1e-63 213.0 0.1 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Methyltransf_2 PF00891.18 EMD61776.1 - 4.4e-18 65.3 0.0 7.7e-18 64.6 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain MTS PF05175.14 EMD61776.1 - 0.0081 15.7 0.8 2.2 7.8 0.1 2.7 2 1 0 2 2 2 2 Methyltransferase small domain DUF3652 PF12372.8 EMD61776.1 - 0.13 12.2 0.2 45 4.1 0.0 3.3 3 0 0 3 3 3 0 Huntingtin protein region VanW PF04294.13 EMD61776.1 - 0.14 11.9 0.0 0.22 11.2 0.0 1.3 1 0 0 1 1 1 0 VanW like protein Pyridoxal_deC PF00282.19 EMD61777.1 - 1.9e-75 253.9 0.0 5.9e-75 252.3 0.0 1.7 2 0 0 2 2 2 1 Pyridoxal-dependent decarboxylase conserved domain Beta_elim_lyase PF01212.21 EMD61777.1 - 0.00029 20.2 0.0 0.00042 19.7 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.19 EMD61777.1 - 0.011 14.7 0.0 0.022 13.7 0.0 1.5 2 0 0 2 2 2 0 Aminotransferase class-V AMP-binding PF00501.28 EMD61778.1 - 1.1e-222 739.2 0.3 8.9e-75 251.9 0.0 3.4 3 0 0 3 3 3 3 AMP-binding enzyme Condensation PF00668.20 EMD61778.1 - 1.2e-170 568.2 0.0 1.3e-83 281.3 0.0 3.2 3 0 0 3 3 3 3 Condensation domain PP-binding PF00550.25 EMD61778.1 - 1.3e-43 147.1 2.1 2.1e-14 53.6 0.0 4.4 4 0 0 4 4 4 3 Phosphopantetheine attachment site AMP-binding_C PF13193.6 EMD61778.1 - 3e-16 60.1 1.1 0.0075 17.2 0.0 4.9 4 0 0 4 4 4 4 AMP-binding enzyme C-terminal domain Methyltransf_23 PF13489.6 EMD61778.1 - 2e-06 27.8 0.0 0.00017 21.5 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMD61778.1 - 1.7e-05 25.4 0.0 5.7e-05 23.7 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMD61778.1 - 0.00027 21.6 0.0 0.00079 20.1 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMD61778.1 - 0.0019 18.8 0.0 0.0081 16.8 0.0 2.2 1 0 0 1 1 1 1 Methyltransferase domain T2SSI PF02501.17 EMD61778.1 - 0.012 15.7 0.6 3.1 8.0 0.0 3.2 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein I Methyltransf_31 PF13847.6 EMD61778.1 - 0.017 14.9 0.0 0.045 13.5 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain DUF2806 PF10987.8 EMD61778.1 - 0.058 13.3 4.3 21 4.9 0.1 4.0 4 0 0 4 4 4 0 Protein of unknown function (DUF2806) TraH PF06122.11 EMD61778.1 - 0.096 11.9 0.0 0.2 10.9 0.0 1.5 1 0 0 1 1 1 0 Conjugative relaxosome accessory transposon protein Cas1_AcylT PF07779.12 EMD61778.1 - 0.098 11.6 0.0 0.17 10.8 0.0 1.2 1 0 0 1 1 1 0 10 TM Acyl Transferase domain found in Cas1p Methyltransf_16 PF10294.9 EMD61778.1 - 0.18 11.6 0.0 0.37 10.5 0.0 1.4 1 0 0 1 1 1 0 Lysine methyltransferase NAD_binding_4 PF07993.12 EMD61779.1 - 6.3e-33 114.0 0.0 1.5e-32 112.8 0.0 1.6 1 1 0 1 1 1 1 Male sterility protein Epimerase PF01370.21 EMD61779.1 - 4.3e-10 39.5 0.0 6.5e-10 38.9 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EMD61779.1 - 0.0017 17.4 0.0 0.0031 16.6 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family AMP-binding PF00501.28 EMD61780.1 - 6.3e-176 585.1 1.5 1.3e-84 284.3 0.0 3.7 4 0 0 4 4 4 3 AMP-binding enzyme Condensation PF00668.20 EMD61780.1 - 2.7e-134 448.3 0.0 1e-86 291.4 0.0 2.3 2 0 0 2 2 2 2 Condensation domain PP-binding PF00550.25 EMD61780.1 - 7.6e-42 141.5 1.6 9.3e-14 51.5 0.1 3.6 3 0 0 3 3 3 3 Phosphopantetheine attachment site AMP-binding_C PF13193.6 EMD61780.1 - 5.5e-19 68.9 3.5 0.0029 18.5 0.0 4.9 4 0 0 4 4 4 4 AMP-binding enzyme C-terminal domain Methyltransf_23 PF13489.6 EMD61780.1 - 0.00012 22.0 0.0 0.00032 20.6 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMD61780.1 - 0.00067 20.3 0.0 0.0023 18.6 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_16 PF10294.9 EMD61780.1 - 0.001 18.8 0.0 0.0019 17.9 0.0 1.4 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_11 PF08241.12 EMD61780.1 - 0.0016 19.0 0.0 0.012 16.3 0.0 2.6 2 0 0 2 2 2 1 Methyltransferase domain Cyclophil_like2 PF18050.1 EMD61780.1 - 0.026 14.5 0.0 1.4 8.9 0.0 2.6 2 0 0 2 2 2 0 Cyclophilin-like family Methyltransf_12 PF08242.12 EMD61780.1 - 0.044 14.5 0.0 0.12 13.2 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain RrnaAD PF00398.20 EMD61780.1 - 0.073 12.1 0.0 0.15 11.1 0.0 1.4 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Methyltransf_31 PF13847.6 EMD61780.1 - 0.18 11.6 0.0 0.42 10.4 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain FAD_binding_3 PF01494.19 EMD61781.1 - 1.4e-27 96.9 0.0 3.6e-27 95.5 0.0 1.7 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 EMD61781.1 - 9e-05 22.6 1.0 0.00031 20.9 1.0 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 EMD61781.1 - 0.00017 20.9 1.4 0.0097 15.2 0.4 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase SE PF08491.10 EMD61781.1 - 0.0003 20.0 0.0 0.0099 15.0 0.0 2.2 2 0 0 2 2 2 1 Squalene epoxidase DAO PF01266.24 EMD61781.1 - 0.0014 18.3 1.8 0.0034 17.0 0.7 2.0 1 1 1 2 2 2 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 EMD61781.1 - 0.0065 15.6 0.3 0.7 8.9 0.5 2.4 2 0 0 2 2 2 1 Lycopene cyclase protein Thi4 PF01946.17 EMD61781.1 - 0.0068 15.7 0.7 0.012 14.9 0.7 1.3 1 0 0 1 1 1 1 Thi4 family Pyr_redox PF00070.27 EMD61781.1 - 0.0097 16.4 2.2 0.56 10.8 0.9 2.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EMD61781.1 - 0.19 10.8 1.2 0.29 10.1 1.2 1.2 1 0 0 1 1 1 0 FAD binding domain Pyr_redox_2 PF07992.14 EMD61781.1 - 8.3 5.5 5.8 2.3 7.4 1.2 2.2 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase ADH_zinc_N PF00107.26 EMD61782.1 - 1.3e-12 47.8 0.0 9.9e-12 45.0 0.0 1.9 2 0 0 2 2 2 1 Zinc-binding dehydrogenase 3HCDH_N PF02737.18 EMD61782.1 - 0.0006 19.7 0.1 0.00076 19.4 0.1 1.2 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 EMD61782.1 - 0.0021 17.4 0.0 0.0031 16.9 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.14 EMD61782.1 - 0.0023 17.5 0.1 0.005 16.4 0.1 1.7 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_binding_2 PF03446.15 EMD61782.1 - 0.012 15.8 0.1 0.49 10.6 0.1 2.1 1 1 1 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase AlaDh_PNT_C PF01262.21 EMD61782.1 - 0.032 13.5 0.1 0.047 13.0 0.1 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain ADH_N PF08240.12 EMD61782.1 - 0.043 13.7 0.4 1.3 8.9 0.0 2.7 2 1 1 3 3 3 0 Alcohol dehydrogenase GroES-like domain F420_oxidored PF03807.17 EMD61782.1 - 0.047 14.3 0.0 0.13 12.9 0.0 1.7 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent FAD_binding_3 PF01494.19 EMD61782.1 - 0.049 12.9 0.0 0.062 12.5 0.0 1.1 1 0 0 1 1 1 0 FAD binding domain TrkA_N PF02254.18 EMD61782.1 - 0.058 13.7 0.1 0.089 13.1 0.1 1.3 1 0 0 1 1 1 0 TrkA-N domain Shikimate_DH PF01488.20 EMD61782.1 - 0.069 13.2 0.0 0.1 12.6 0.0 1.2 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Pyr_redox_2 PF07992.14 EMD61782.1 - 0.07 12.3 0.0 0.089 12.0 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DUF43 PF01861.16 EMD61782.1 - 0.16 11.1 0.0 0.23 10.6 0.0 1.2 1 0 0 1 1 1 0 Branched-chain polyamine synthase A C-terminal domain Ldi PF18566.1 EMD61783.1 - 1.9e-66 224.7 0.6 1.8e-60 205.1 0.1 2.1 1 1 1 2 2 2 2 Linalool dehydratase/isomerase DUF3425 PF11905.8 EMD61784.1 - 8.5e-12 45.1 0.1 1.6e-11 44.2 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) bZIP_1 PF00170.21 EMD61784.1 - 0.0084 16.2 5.4 0.018 15.1 5.0 1.7 1 1 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EMD61784.1 - 3.9 7.6 9.5 1e+02 3.1 9.5 2.3 1 1 0 1 1 1 0 Basic region leucine zipper E1-E2_ATPase PF00122.20 EMD61785.1 - 5.4e-32 110.8 0.2 1.2e-31 109.6 0.2 1.6 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 EMD61785.1 - 1.1e-24 87.8 0.3 1.9e-24 87.2 0.3 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HMA PF00403.26 EMD61785.1 - 1.4e-08 35.1 0.0 3.2e-08 33.9 0.0 1.7 1 0 0 1 1 1 1 Heavy-metal-associated domain HAD PF12710.7 EMD61785.1 - 0.0019 18.6 0.0 0.0038 17.7 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase LUD_dom PF02589.15 EMD61785.1 - 0.0061 16.3 0.0 0.014 15.1 0.0 1.6 1 0 0 1 1 1 1 LUD domain ketoacyl-synt PF00109.26 EMD61786.1 - 2.8e-51 174.5 0.0 6.4e-51 173.4 0.0 1.6 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 EMD61786.1 - 1.8e-33 115.0 2.0 3.9e-33 114.0 1.5 1.8 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.23 EMD61786.1 - 1.9e-05 24.2 0.0 4.3e-05 23.0 0.0 1.6 1 0 0 1 1 1 1 Thiolase, N-terminal domain ACP_syn_III PF08545.10 EMD61786.1 - 0.0084 15.9 0.2 0.03 14.2 0.0 2.0 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III PheRS_DBD1 PF18552.1 EMD61786.1 - 0.049 13.4 0.2 0.12 12.2 0.2 1.6 1 0 0 1 1 1 0 PheRS DNA binding domain 1 TrbI_Ftype PF09677.10 EMD61787.1 - 0.05 13.9 0.0 0.22 11.9 0.0 1.8 2 0 0 2 2 2 0 Type-F conjugative transfer system protein (TrbI_Ftype) FeS_assembly_P PF01883.19 EMD61787.1 - 0.14 12.3 0.0 0.27 11.4 0.0 1.4 1 0 0 1 1 1 0 Iron-sulfur cluster assembly protein zf-3CxxC PF13695.6 EMD61788.1 - 8.7e-20 71.1 4.0 8.7e-20 71.1 4.0 3.2 2 1 1 3 3 3 2 Zinc-binding domain zf-C2H2_jaz PF12171.8 EMD61788.1 - 2.7e-08 33.9 4.4 7.2e-05 23.0 0.4 3.7 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EMD61788.1 - 0.0003 21.1 7.5 0.0047 17.3 1.3 4.2 5 0 0 5 5 5 2 Zinc-finger of C2H2 type zf-C2H2 PF00096.26 EMD61788.1 - 0.045 14.2 1.5 0.045 14.2 1.5 4.7 5 0 0 5 5 5 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMD61788.1 - 0.093 13.6 0.5 0.093 13.6 0.5 4.6 6 0 0 6 6 6 0 C2H2-type zinc finger zf-C2H2_8 PF15909.5 EMD61788.1 - 7.2 7.0 16.5 0.16 12.3 7.1 2.7 2 2 0 2 2 2 0 C2H2-type zinc ribbon P-mevalo_kinase PF04275.14 EMD61789.1 - 3.7e-19 68.7 0.0 6.4e-19 68.0 0.0 1.4 1 0 0 1 1 1 1 Phosphomevalonate kinase Pribosyltran PF00156.27 EMD61789.1 - 3.4e-18 65.7 0.0 7.7e-18 64.5 0.0 1.6 1 0 0 1 1 1 1 Phosphoribosyl transferase domain FAD_binding_4 PF01565.23 EMD61789.1 - 1.5e-13 50.7 2.4 4.5e-13 49.1 2.4 1.9 1 0 0 1 1 1 1 FAD binding domain Methyltransf_23 PF13489.6 EMD61789.1 - 0.0035 17.2 0.0 0.011 15.6 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain UPRTase PF14681.6 EMD61789.1 - 0.0037 16.7 0.0 0.0085 15.5 0.0 1.5 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase BBE PF08031.12 EMD61789.1 - 0.059 13.5 0.0 0.23 11.6 0.0 2.0 2 0 0 2 2 2 0 Berberine and berberine like PRTase_2 PF15609.6 EMD61789.1 - 0.076 12.5 0.1 0.17 11.4 0.1 1.5 1 0 0 1 1 1 0 Phosphoribosyl transferase zf-C2H2_jaz PF12171.8 EMD61791.1 - 9.3e-22 76.8 33.3 4.9e-05 23.5 5.5 6.6 6 0 0 6 6 6 5 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EMD61791.1 - 1.2e-19 70.0 39.4 0.00089 19.6 0.5 7.5 6 1 0 7 7 7 6 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 EMD61791.1 - 3.9e-15 55.3 36.7 0.009 16.8 0.2 7.7 6 1 1 7 7 7 6 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EMD61791.1 - 1.5e-13 50.4 40.3 0.00027 20.8 0.6 7.1 7 0 0 7 7 7 5 C2H2-type zinc finger zf-C2H2_2 PF12756.7 EMD61791.1 - 2.4e-12 47.1 40.7 0.033 14.5 1.1 7.0 2 2 5 7 7 7 5 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.26 EMD61791.1 - 4.2e-10 39.5 41.9 0.072 13.6 0.1 7.5 6 1 0 7 7 7 6 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMD61791.1 - 0.0071 16.7 38.9 0.068 13.6 0.1 7.4 7 0 0 7 7 7 2 Zinc-finger double domain ABM PF03992.16 EMD61791.1 - 0.011 15.9 0.1 0.32 11.2 0.0 2.8 3 0 0 3 3 3 0 Antibiotic biosynthesis monooxygenase PI3K_p85B PF02192.16 EMD61791.1 - 0.084 12.6 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 PI3-kinase family, p85-binding domain zf-C2H2_11 PF16622.5 EMD61791.1 - 0.084 12.7 0.5 0.084 12.7 0.5 6.4 6 1 1 7 7 7 0 zinc-finger C2H2-type Zn-ribbon_8 PF09723.10 EMD61791.1 - 0.18 11.9 34.9 19 5.5 0.5 6.9 5 1 1 6 6 6 0 Zinc ribbon domain Rad50_zn_hook PF04423.14 EMD61791.1 - 2.3 8.1 13.0 8.8 6.3 0.0 4.5 5 0 0 5 5 5 0 Rad50 zinc hook motif Dynamin_N PF00350.23 EMD61792.1 - 5.7e-08 33.0 1.0 0.00051 20.1 0.0 2.9 2 1 1 3 3 3 2 Dynamin family Dynamin_M PF01031.20 EMD61792.1 - 4.1e-07 29.5 0.5 9.5e-06 25.0 0.0 2.8 2 1 1 3 3 3 1 Dynamin central region adh_short PF00106.25 EMD61793.1 - 1.8e-13 50.4 0.2 2.5e-13 49.9 0.2 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD61793.1 - 1.7e-11 44.2 0.1 2.2e-11 43.8 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD61793.1 - 4.1e-06 26.8 1.3 0.0001 22.3 1.3 2.0 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 EMD61793.1 - 0.022 14.2 0.1 0.029 13.8 0.1 1.1 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Sugar_tr PF00083.24 EMD61794.1 - 3.4e-99 332.8 22.2 4e-99 332.5 22.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD61794.1 - 6.2e-23 81.3 20.3 6.2e-23 81.3 20.3 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily Phage_holin_3_2 PF04550.12 EMD61794.1 - 0.054 14.1 0.4 0.19 12.3 0.4 2.0 1 0 0 1 1 1 0 Phage holin family 2 Velvet PF11754.8 EMD61795.1 - 2e-47 162.3 0.0 2.4e-47 162.0 0.0 1.0 1 0 0 1 1 1 1 Velvet factor zf-C3HC4_3 PF13920.6 EMD61796.1 - 4.3e-06 26.5 10.2 4.3e-06 26.5 10.2 3.6 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) Tudor-knot PF11717.8 EMD61796.1 - 0.17 11.8 0.2 0.46 10.4 0.2 1.6 1 0 0 1 1 1 0 RNA binding activity-knot of a chromodomain Mnd1 PF03962.15 EMD61797.1 - 2.3e-23 82.3 0.6 4.8e-23 81.2 0.1 1.8 2 0 0 2 2 2 1 Mnd1 HTH domain DUF4315 PF14193.6 EMD61797.1 - 0.02 14.9 1.3 0.02 14.9 1.3 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF4315) LZ3wCH PF18517.1 EMD61797.1 - 0.029 14.5 1.3 0.2 11.8 0.0 2.7 2 1 0 2 2 2 0 Leucine zipper with capping helix domain STAT_alpha PF01017.20 EMD61797.1 - 0.24 11.3 2.9 0.17 11.8 1.0 1.6 2 0 0 2 2 2 0 STAT protein, all-alpha domain DUF4407 PF14362.6 EMD61797.1 - 0.28 10.5 5.1 0.32 10.3 5.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) ADIP PF11559.8 EMD61797.1 - 0.3 11.2 8.9 0.5 10.4 8.9 1.3 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding FUSC PF04632.12 EMD61797.1 - 0.31 9.5 0.5 0.34 9.4 0.5 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family TPR_MLP1_2 PF07926.12 EMD61797.1 - 0.61 10.2 13.0 1.9 8.6 1.9 2.5 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Spc7 PF08317.11 EMD61797.1 - 0.7 8.7 12.1 0.63 8.9 2.1 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein Seryl_tRNA_N PF02403.22 EMD61797.1 - 1.6 9.0 7.9 13 6.1 0.2 2.6 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF1690 PF07956.11 EMD61797.1 - 6.9 7.1 8.8 14 6.1 8.8 1.4 1 0 0 1 1 1 0 Protein of Unknown function (DUF1690) WD40 PF00400.32 EMD61799.1 - 1.1e-18 67.3 11.7 5e-05 24.0 0.5 6.1 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD61799.1 - 3.9e-10 39.9 0.2 0.22 11.8 0.0 5.6 3 1 3 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EMD61799.1 - 0.13 10.8 0.6 6.4 5.3 0.1 2.7 2 1 1 3 3 3 0 Nucleoporin Nup120/160 Methyltransf_16 PF10294.9 EMD61801.1 - 1.4e-45 155.1 0.0 1.8e-45 154.8 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_25 PF13649.6 EMD61801.1 - 0.0013 19.4 0.0 0.0034 18.1 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMD61801.1 - 0.015 15.1 0.0 0.023 14.5 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.14 EMD61801.1 - 0.021 14.4 0.0 0.034 13.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_12 PF08242.12 EMD61801.1 - 0.15 12.8 0.0 0.29 11.9 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain SIT PF15330.6 EMD61802.1 - 0.058 13.9 0.0 0.13 12.7 0.0 1.6 1 0 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT FtsK_4TM PF13491.6 EMD61802.1 - 0.13 11.9 2.5 0.15 11.8 1.2 1.7 1 1 1 2 2 2 0 4TM region of DNA translocase FtsK/SpoIIIE DAP10 PF07213.11 EMD61802.1 - 0.14 12.1 0.8 0.41 10.6 0.0 2.1 2 0 0 2 2 2 0 DAP10 membrane protein CoA_binding_3 PF13727.6 EMD61802.1 - 0.17 11.9 0.1 0.37 10.8 0.1 1.5 1 0 0 1 1 1 0 CoA-binding domain DUF2615 PF11027.8 EMD61804.1 - 0.14 12.4 0.2 0.44 10.7 0.2 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2615) DEAD PF00270.29 EMD61805.1 - 4.4e-46 156.9 0.0 9.9e-46 155.7 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EMD61805.1 - 2.3e-29 101.9 0.0 4.4e-28 97.8 0.1 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF2986 PF11661.8 EMD61805.1 - 0.00062 20.2 2.4 0.00062 20.2 2.4 2.7 3 0 0 3 3 3 1 Protein of unknown function (DUF2986) CMS1 PF14617.6 EMD61805.1 - 0.1 12.0 0.0 0.1 12.0 0.0 2.3 3 0 0 3 3 3 0 U3-containing 90S pre-ribosomal complex subunit DUF3135 PF11333.8 EMD61805.1 - 0.65 10.3 3.6 0.52 10.6 0.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3135) Proteasome PF00227.26 EMD61806.1 - 1.6e-39 135.4 0.0 1.9e-39 135.1 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit Mitoc_mL59 PF18126.1 EMD61807.1 - 3.7e-43 146.9 3.6 7e-43 146.0 3.6 1.4 1 1 0 1 1 1 1 Mitochondrial ribosomal protein mL59 ThiD2 PF17792.1 EMD61808.1 - 2 8.9 6.7 1.2 9.6 3.7 1.9 2 0 0 2 2 2 0 ThiD2 family Proteasome PF00227.26 EMD61809.1 - 9.8e-46 155.6 0.1 2.6e-30 105.3 0.0 2.5 2 1 1 3 3 3 2 Proteasome subunit Proteasome_A_N PF10584.9 EMD61809.1 - 5.6e-12 45.1 1.0 6.2e-12 45.0 0.0 1.6 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature Arm-DNA-bind_3 PF13356.6 EMD61809.1 - 0.08 13.3 0.1 3.3 8.2 0.0 2.4 2 0 0 2 2 2 0 Arm DNA-binding domain His_Phos_1 PF00300.22 EMD61810.1 - 8.8e-18 64.7 0.0 1.5e-17 63.9 0.0 1.4 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) ADP_PFK_GK PF04587.15 EMD61811.1 - 0.11 11.0 0.1 0.14 10.7 0.1 1.2 1 0 0 1 1 1 0 ADP-specific Phosphofructokinase/Glucokinase conserved region ADK PF00406.22 EMD61812.1 - 2e-44 151.3 0.0 2.7e-44 150.9 0.0 1.2 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 EMD61812.1 - 5e-34 117.6 0.0 8.4e-34 116.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EMD61812.1 - 3e-07 31.0 0.0 4.5e-07 30.5 0.0 1.2 1 0 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.17 EMD61812.1 - 0.00025 20.8 0.2 0.018 14.7 0.0 2.1 2 0 0 2 2 2 1 Thymidylate kinase AAA_33 PF13671.6 EMD61812.1 - 0.012 15.7 0.1 0.2 11.8 0.1 2.2 1 1 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.18 EMD61812.1 - 0.019 14.7 0.0 0.033 13.9 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase PCI PF01399.27 EMD61813.1 - 2.7e-12 47.1 0.0 1e-11 45.2 0.0 2.1 2 0 0 2 2 2 1 PCI domain eIF3m_C_helix PF18005.1 EMD61813.1 - 1.6e-11 43.7 1.3 1.6e-11 43.7 1.3 2.2 2 0 0 2 2 2 1 eIF3 subunit M, C-terminal helix TPR_14 PF13428.6 EMD61813.1 - 0.23 12.4 2.5 0.75 10.8 0.7 2.9 2 1 1 3 3 3 0 Tetratricopeptide repeat PAH PF02671.21 EMD61813.1 - 0.46 10.7 2.1 3.4 7.9 0.3 2.9 2 1 1 3 3 3 0 Paired amphipathic helix repeat Sugar_tr PF00083.24 EMD61817.1 - 2.1e-84 284.0 17.3 2.4e-84 283.8 17.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD61817.1 - 3e-18 65.9 32.2 1.2e-10 40.9 15.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EMD61817.1 - 0.001 17.7 20.9 0.031 12.8 3.8 2.7 2 1 1 3 3 3 2 MFS/sugar transport protein Alpha-amylase PF00128.24 EMD61818.1 - 8.1e-114 380.7 0.8 8.1e-114 380.7 0.8 1.5 2 0 0 2 2 2 1 Alpha amylase, catalytic domain Malt_amylase_C PF16657.5 EMD61818.1 - 5.6e-05 23.2 0.0 0.00012 22.1 0.0 1.6 1 0 0 1 1 1 1 Maltogenic Amylase, C-terminal domain DUF3459 PF11941.8 EMD61818.1 - 0.00038 20.7 0.0 0.00077 19.7 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3459) hDGE_amylase PF14701.6 EMD61818.1 - 0.0066 15.6 0.0 0.025 13.7 0.0 1.8 2 0 0 2 2 2 1 Glycogen debranching enzyme, glucanotransferase domain HBB PF06777.11 EMD61818.1 - 0.14 11.8 0.0 20 4.8 0.0 2.3 2 0 0 2 2 2 0 Helical and beta-bridge domain Zn_clus PF00172.18 EMD61819.1 - 1.2e-07 31.7 12.8 2.4e-07 30.7 12.8 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain UPF0029 PF01205.19 EMD61821.1 - 5.2e-18 65.3 0.0 1.8e-17 63.6 0.0 1.8 2 0 0 2 2 2 1 Uncharacterized protein family UPF0029 RRM_3 PF08777.11 EMD61821.1 - 0.044 13.8 0.5 0.083 12.9 0.5 1.5 1 0 0 1 1 1 0 RNA binding motif Ribosomal_L34 PF00468.17 EMD61822.1 - 3e-18 65.5 7.1 6.4e-18 64.4 7.1 1.6 1 0 0 1 1 1 1 Ribosomal protein L34 Peptidase_M48_N PF16491.5 EMD61824.1 - 6.4e-61 205.4 6.7 6.4e-61 205.4 6.7 1.6 2 0 0 2 2 2 1 CAAX prenyl protease N-terminal, five membrane helices Peptidase_M48 PF01435.18 EMD61824.1 - 7e-44 149.9 0.0 5e-43 147.2 0.0 2.0 2 0 0 2 2 2 1 Peptidase family M48 Peptidase_M56 PF05569.11 EMD61824.1 - 0.0011 18.3 1.8 0.0057 15.9 1.1 2.3 2 1 0 2 2 2 1 BlaR1 peptidase M56 SprT-like PF10263.9 EMD61824.1 - 0.046 13.6 0.1 0.082 12.8 0.1 1.4 1 0 0 1 1 1 0 SprT-like family DUF4538 PF15061.6 EMD61824.1 - 0.18 11.5 4.0 0.084 12.6 0.8 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4538) Asp PF00026.23 EMD61825.1 - 1e-27 97.4 0.0 2.2e-25 89.8 0.0 2.2 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EMD61825.1 - 7.2e-10 39.4 0.4 2.8e-07 30.9 0.6 2.8 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal TRAP_alpha PF03896.16 EMD61826.1 - 0.0045 16.2 0.1 0.0049 16.1 0.1 1.2 1 0 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit PepSY_TM PF03929.16 EMD61826.1 - 0.039 13.6 0.0 0.047 13.4 0.0 1.2 1 0 0 1 1 1 0 PepSY-associated TM region CDC45 PF02724.14 EMD61826.1 - 0.07 11.4 13.0 0.084 11.2 13.0 1.0 1 0 0 1 1 1 0 CDC45-like protein SKN1 PF03935.15 EMD61826.1 - 0.11 10.9 0.0 0.14 10.5 0.0 1.1 1 0 0 1 1 1 0 Beta-glucan synthesis-associated protein (SKN1) Pet100 PF09803.9 EMD61826.1 - 8.5 7.0 7.7 1.5 9.4 2.6 2.2 1 1 1 2 2 2 0 Pet100 Fungal_trans PF04082.18 EMD61827.1 - 1.4e-16 60.3 2.6 1.4e-16 60.3 2.6 2.2 3 0 0 3 3 3 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD61827.1 - 1.4e-08 34.7 9.8 2.2e-08 34.1 9.8 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RVT_1 PF00078.27 EMD61828.1 - 6.9e-06 25.7 2.2 7.8e-06 25.6 2.2 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) HTH_psq PF05225.16 EMD61830.1 - 1.5e-05 24.6 0.1 1.9e-05 24.3 0.1 1.2 1 0 0 1 1 1 1 helix-turn-helix, Psq domain CENP-B_N PF04218.13 EMD61830.1 - 0.016 14.8 0.0 0.025 14.2 0.0 1.3 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain HTH_10 PF04967.12 EMD61830.1 - 0.078 12.8 0.0 0.11 12.4 0.0 1.2 1 0 0 1 1 1 0 HTH DNA binding domain RRS1 PF04939.12 EMD61831.1 - 6.6e-59 198.4 6.0 8e-59 198.1 6.0 1.1 1 0 0 1 1 1 1 Ribosome biogenesis regulatory protein (RRS1) DAP3 PF10236.9 EMD61832.1 - 4.2e-99 331.6 0.0 5.2e-99 331.3 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal death-associated protein 3 AAA_14 PF13173.6 EMD61832.1 - 0.094 12.8 0.0 3.7 7.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain Autophagy_act_C PF03987.15 EMD61833.1 - 6.1e-14 52.3 1.6 1e-13 51.6 1.6 1.3 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain Pkinase PF00069.25 EMD61834.1 - 1e-73 247.9 0.0 2e-73 247.0 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD61834.1 - 2.6e-35 122.0 0.0 3.7e-35 121.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.26 EMD61834.1 - 2e-16 60.1 0.1 5.8e-16 58.6 0.1 1.9 2 0 0 2 2 2 1 FHA domain Kinase-like PF14531.6 EMD61834.1 - 4.6e-11 42.6 0.0 7.1e-10 38.7 0.0 2.1 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 EMD61834.1 - 3.2e-08 32.8 0.2 3.9e-07 29.2 0.0 2.1 2 0 0 2 2 2 1 Fungal protein kinase Yop-YscD_cpl PF16697.5 EMD61834.1 - 2.8e-07 30.8 0.1 1.1e-06 28.8 0.0 2.0 2 0 0 2 2 2 1 Inner membrane component of T3SS, cytoplasmic domain Kdo PF06293.14 EMD61834.1 - 0.006 16.0 0.0 0.012 15.0 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pox_ser-thr_kin PF05445.11 EMD61834.1 - 0.045 12.7 0.0 0.071 12.1 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase DUF2961 PF11175.8 EMD61834.1 - 0.073 12.7 0.1 7.5 6.1 0.0 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2961) RIO1 PF01163.22 EMD61834.1 - 0.093 12.3 0.0 0.21 11.2 0.0 1.5 1 0 0 1 1 1 0 RIO1 family YrbL-PhoP_reg PF10707.9 EMD61834.1 - 0.095 12.2 0.0 0.21 11.1 0.0 1.6 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL ThiS PF02597.20 EMD61834.1 - 0.1 13.2 0.1 0.52 11.0 0.1 2.2 1 1 0 1 1 1 0 ThiS family p450 PF00067.22 EMD61835.1 - 1.8e-76 257.8 0.0 2.2e-76 257.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Pam17 PF08566.10 EMD61836.1 - 1.6e-57 193.9 0.0 2.2e-57 193.5 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial import protein Pam17 AA_permease PF00324.21 EMD61838.1 - 3.7e-137 457.8 42.6 4.6e-137 457.5 42.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EMD61838.1 - 2.1e-35 122.4 45.6 2.6e-35 122.1 45.6 1.1 1 0 0 1 1 1 1 Amino acid permease LysM PF01476.20 EMD61843.1 - 6.9e-10 38.8 0.1 1.8e-07 31.1 0.1 2.2 2 0 0 2 2 2 2 LysM domain Toxin_32 PF08120.11 EMD61843.1 - 0.94 9.3 3.5 0.49 10.3 0.7 1.9 2 0 0 2 2 2 0 Tamulustoxin family Methyltransf_11 PF08241.12 EMD61844.1 - 8.8e-10 39.1 0.0 2.2e-09 37.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMD61844.1 - 3.4e-05 24.5 0.0 8.3e-05 23.2 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMD61844.1 - 0.036 14.8 0.0 0.076 13.8 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Ubie_methyltran PF01209.18 EMD61844.1 - 0.067 12.5 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Xan_ur_permease PF00860.20 EMD61845.1 - 2e-21 76.2 31.3 4.3e-21 75.1 26.8 2.5 2 1 0 2 2 2 1 Permease family Sulfate_transp PF00916.20 EMD61845.1 - 2.4e-05 23.3 20.3 0.00041 19.2 4.1 2.7 2 1 1 3 3 3 2 Sulfate permease family F-box PF00646.33 EMD61847.1 - 2e-07 30.7 0.8 3.8e-07 29.8 0.8 1.4 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EMD61847.1 - 0.0006 19.6 0.9 0.0014 18.5 0.2 1.9 2 0 0 2 2 2 1 F-box-like SIN1 PF05422.12 EMD61850.1 - 7.8 7.0 14.0 7.1 7.2 12.8 1.5 1 1 0 1 1 1 0 Stress-activated map kinase interacting protein 1 (SIN1) Sugar_tr PF00083.24 EMD61852.1 - 2.1e-84 284.0 26.2 2.5e-84 283.7 26.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD61852.1 - 3.2e-36 125.0 47.0 1.7e-31 109.4 25.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EMD61852.1 - 0.0016 17.0 3.5 0.0016 17.0 3.5 1.6 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Glyco_hydro_2_C PF02836.17 EMD61853.1 - 1.4e-102 342.9 0.3 2.2e-102 342.2 0.3 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Bgal_small_N PF02929.17 EMD61853.1 - 3.3e-67 226.7 0.0 5.9e-67 225.8 0.0 1.4 1 0 0 1 1 1 1 Beta galactosidase small chain Glyco_hydro_2_N PF02837.18 EMD61853.1 - 2.8e-44 151.0 0.2 7.5e-44 149.6 0.2 1.8 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain DUF4981 PF16353.5 EMD61853.1 - 8.3e-20 71.1 0.0 5.1e-19 68.5 0.0 2.4 2 0 0 2 2 2 1 Domain of unknown function(DUF4981) Glyco_hydro_2 PF00703.21 EMD61853.1 - 8.5e-13 49.0 0.1 2.5e-12 47.5 0.1 1.9 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 BetaGal_dom4_5 PF13364.6 EMD61853.1 - 0.0005 20.6 0.0 0.0022 18.5 0.0 2.1 1 0 0 1 1 1 1 Beta-galactosidase jelly roll domain CBM60 PF16841.5 EMD61853.1 - 0.16 12.4 0.0 0.79 10.2 0.0 2.3 1 0 0 1 1 1 0 Ca-dependent carbohydrate-binding module xylan-binding WBS_methylT PF12589.8 EMD61854.1 - 5 7.9 11.2 1.6 9.6 0.2 3.0 4 0 0 4 4 4 0 Methyltransferase involved in Williams-Beuren syndrome FAD_binding_4 PF01565.23 EMD61855.1 - 7.6e-27 93.7 0.0 1.2e-26 93.1 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain FAD-oxidase_C PF02913.19 EMD61855.1 - 4.3e-10 39.6 0.0 6.8e-10 39.0 0.0 1.3 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain zf-H2C2_2 PF13465.6 EMD61858.1 - 8.5e-14 51.3 20.3 7.4e-07 29.3 3.3 3.7 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2 PF00096.26 EMD61858.1 - 3.8e-08 33.4 31.0 0.0033 17.8 3.2 4.4 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 EMD61858.1 - 0.00021 21.2 19.4 0.071 13.1 0.9 3.7 3 0 0 3 3 3 2 C2H2-type zinc finger zf-Di19 PF05605.12 EMD61858.1 - 0.0014 18.9 6.1 0.0038 17.5 6.1 1.8 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding FlxA PF14282.6 EMD61858.1 - 0.0033 17.4 1.0 0.0033 17.4 1.0 2.0 2 0 0 2 2 1 1 FlxA-like protein FAM184 PF15665.5 EMD61858.1 - 0.0094 15.8 2.1 0.015 15.1 2.1 1.3 1 0 0 1 1 1 1 Family with sequence similarity 184, A and B GAGA PF09237.11 EMD61858.1 - 0.011 15.5 7.9 0.016 15.0 1.4 2.7 1 1 1 2 2 2 0 GAGA factor FAM76 PF16046.5 EMD61858.1 - 0.02 14.3 0.5 0.02 14.3 0.5 2.9 3 1 0 3 3 3 0 FAM76 protein zf-C2H2_4 PF13894.6 EMD61858.1 - 0.022 15.6 16.1 0.029 15.2 6.4 4.6 5 0 0 5 5 3 0 C2H2-type zinc finger FYVE PF01363.21 EMD61858.1 - 0.039 14.1 4.9 0.15 12.2 0.4 2.4 2 0 0 2 2 2 0 FYVE zinc finger zf-C2H2_jaz PF12171.8 EMD61858.1 - 0.046 14.0 7.6 3.8 7.9 2.3 3.2 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding Mito_fiss_reg PF05308.11 EMD61858.1 - 0.051 13.7 0.2 0.051 13.7 0.2 3.7 4 1 0 4 4 2 0 Mitochondrial fission regulator SurA_N_2 PF13623.6 EMD61858.1 - 0.056 13.3 1.0 0.089 12.7 1.0 1.3 1 0 0 1 1 1 0 SurA N-terminal domain zf-C2HC_2 PF13913.6 EMD61858.1 - 0.062 13.2 0.6 0.062 13.2 0.6 2.7 3 0 0 3 3 2 0 zinc-finger of a C2HC-type zf-C2H2_9 PF16293.5 EMD61858.1 - 0.15 12.0 4.9 5 7.1 0.2 2.9 2 1 1 3 3 2 0 C2H2 type zinc-finger (1 copy) zf-CHCC PF10276.9 EMD61858.1 - 0.71 10.0 8.4 1.2 9.2 0.3 3.3 3 0 0 3 3 3 0 Zinc-finger domain Zn-ribbon_8 PF09723.10 EMD61858.1 - 0.72 10.0 7.6 0.97 9.6 2.3 2.6 1 1 2 3 3 3 0 Zinc ribbon domain DZR PF12773.7 EMD61858.1 - 0.81 9.8 8.2 12 6.1 8.2 2.3 1 1 1 2 2 2 0 Double zinc ribbon Rad50_zn_hook PF04423.14 EMD61858.1 - 1.1 9.2 13.9 0.34 10.8 1.3 3.5 3 1 1 4 4 3 0 Rad50 zinc hook motif zf-BED PF02892.15 EMD61858.1 - 1.6 8.8 10.8 7.6 6.6 4.6 3.7 2 1 1 3 3 3 0 BED zinc finger zinc_ribbon_9 PF14369.6 EMD61858.1 - 4 7.8 5.8 26 5.2 0.1 3.3 3 0 0 3 3 3 0 zinc-ribbon C1_4 PF07975.12 EMD61858.1 - 6.1 7.2 7.7 1.2e+02 3.0 0.2 2.8 1 1 2 3 3 3 0 TFIIH C1-like domain Pkinase PF00069.25 EMD61860.1 - 1.6e-66 224.4 0.0 2.1e-66 224.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD61860.1 - 7.5e-49 166.3 0.0 1.2e-48 165.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EMD61860.1 - 0.0018 17.1 0.0 0.0027 16.5 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase PI3_PI4_kinase PF00454.27 EMD61861.1 - 3.2e-38 132.0 0.0 1.5e-28 100.3 0.1 2.4 1 1 1 2 2 2 2 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 EMD61861.1 - 2.6e-24 85.6 0.3 6.4e-24 84.4 0.3 1.6 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) MFS_1 PF07690.16 EMD61862.1 - 7.6e-31 107.3 53.4 9.8e-31 106.9 49.4 2.7 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EMD61862.1 - 8.2e-10 37.7 12.9 8.2e-10 37.7 12.9 2.4 1 1 0 2 2 2 2 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EMD61862.1 - 6.3e-07 28.6 6.0 6.3e-07 28.6 6.0 3.1 3 1 0 3 3 3 1 Sugar (and other) transporter DUF3377 PF11857.8 EMD61862.1 - 0.13 12.2 0.0 0.47 10.4 0.0 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) TrwB_AAD_bind PF10412.9 EMD61862.1 - 0.14 11.1 0.0 0.21 10.5 0.0 1.2 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain SBP_bac_6 PF13343.6 EMD61863.1 - 7.1e-12 45.3 1.1 1e-11 44.7 1.1 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_8 PF13416.6 EMD61863.1 - 8.2e-08 32.4 1.3 7.6e-07 29.2 1.3 1.9 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_11 PF13531.6 EMD61863.1 - 3.4e-06 27.0 0.0 4.3e-06 26.6 0.0 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 EMD61863.1 - 9e-05 22.6 5.5 0.0016 18.4 5.5 2.1 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein p450 PF00067.22 EMD61869.1 - 5.3e-60 203.5 0.0 6.5e-60 203.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Complex1_LYR PF05347.15 EMD61870.1 - 6.3e-18 64.6 1.0 7.4e-18 64.3 1.0 1.1 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 EMD61870.1 - 1.3e-06 29.1 0.2 1.5e-06 28.9 0.2 1.1 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR_1 PF13232.6 EMD61870.1 - 0.019 15.6 0.8 0.34 11.5 0.2 2.0 1 1 1 2 2 2 0 Complex1_LYR-like HSP20 PF00011.21 EMD61871.1 - 7.3e-23 80.7 2.7 1.4e-14 54.1 0.2 2.3 2 0 0 2 2 2 2 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 EMD61871.1 - 6.6e-08 32.0 0.1 6.9e-07 28.7 0.1 2.1 1 1 0 1 1 1 1 HSP20-like domain found in ArsA Fungal_trans_2 PF11951.8 EMD61872.1 - 1.4e-59 201.9 0.0 1.9e-59 201.4 0.0 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD61872.1 - 5.6e-09 36.0 7.7 1.1e-08 35.1 7.7 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CDI PF02234.19 EMD61873.1 - 0.024 14.8 2.7 0.05 13.8 2.7 1.5 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor YukC PF10140.9 EMD61873.1 - 0.028 13.3 1.0 0.035 12.9 1.0 1.0 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukC DUF4586 PF15239.6 EMD61873.1 - 0.066 13.4 0.2 0.12 12.6 0.2 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4586) YtxH PF12732.7 EMD61873.1 - 0.18 12.4 3.0 0.29 11.7 3.0 1.3 1 0 0 1 1 1 0 YtxH-like protein Caskin-Pro-rich PF16907.5 EMD61873.1 - 1.2 9.7 5.2 0.37 11.3 2.1 1.6 2 0 0 2 2 2 0 Proline rich region of Caskin proteins RAMP4 PF06624.12 EMD61874.1 - 5.5e-17 61.6 0.3 6.2e-17 61.4 0.3 1.0 1 0 0 1 1 1 1 Ribosome associated membrane protein RAMP4 Adaptin_N PF01602.20 EMD61875.1 - 2e-77 261.0 0.0 5.4e-77 259.5 0.0 1.7 1 1 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EMD61875.1 - 0.00013 22.0 0.0 0.003 17.6 0.0 2.3 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 EMD61875.1 - 0.00062 20.2 8.7 1.1 9.8 0.0 5.8 6 0 0 6 6 6 2 HEAT-like repeat HEAT_2 PF13646.6 EMD61875.1 - 0.0031 17.9 0.9 0.11 12.9 0.0 3.4 3 0 0 3 3 3 1 HEAT repeats HEAT PF02985.22 EMD61875.1 - 0.0051 17.0 0.0 13 6.4 0.0 4.0 3 0 0 3 3 3 2 HEAT repeat TPR_14 PF13428.6 EMD61876.1 - 1.6e-07 31.5 3.2 0.0012 19.5 0.4 4.5 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 EMD61876.1 - 1.6e-06 28.5 0.2 0.00023 21.6 0.2 3.2 2 1 1 3 3 3 2 Tetratricopeptide repeat Wzy_C_2 PF11846.8 EMD61876.1 - 2.8e-06 27.4 0.1 0.026 14.4 0.3 2.3 2 0 0 2 2 2 2 Virulence factor membrane-bound polymerase, C-terminal TPR_17 PF13431.6 EMD61876.1 - 0.005 17.1 1.4 9 6.9 0.0 3.9 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 EMD61876.1 - 0.0081 16.8 0.2 0.24 12.1 0.0 2.7 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 EMD61876.1 - 0.01 15.9 1.3 3.7 7.9 0.1 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_9 PF13371.6 EMD61876.1 - 0.023 14.8 0.3 0.1 12.8 0.2 2.0 1 1 1 2 2 2 0 Tetratricopeptide repeat BTAD PF03704.17 EMD61876.1 - 0.038 14.4 0.1 2.1 8.7 0.0 2.4 2 0 0 2 2 2 0 Bacterial transcriptional activator domain Cas_Csy1 PF09611.10 EMD61876.1 - 0.065 12.3 0.0 0.13 11.3 0.0 1.4 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csy1) Orbi_VP5 PF00901.17 EMD61876.1 - 0.095 11.1 0.0 0.13 10.6 0.0 1.1 1 0 0 1 1 1 0 Orbivirus outer capsid protein VP5 F-box-like PF12937.7 EMD61878.1 - 4.8e-05 23.2 0.0 0.00033 20.5 0.0 2.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EMD61878.1 - 0.0005 19.9 0.0 0.0041 17.0 0.0 2.4 2 0 0 2 2 2 1 F-box domain RSN1_7TM PF02714.15 EMD61879.1 - 1.4e-72 244.3 18.5 1.4e-72 244.3 18.5 1.7 2 0 0 2 2 2 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 EMD61879.1 - 1.7e-39 135.1 1.4 1.7e-39 135.1 1.4 2.8 4 0 0 4 4 4 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 EMD61879.1 - 8e-39 133.7 0.0 1.2e-38 133.1 0.0 1.3 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter DUF3671 PF12420.8 EMD61879.1 - 0.17 12.0 12.1 0.032 14.3 1.1 3.3 3 0 0 3 3 3 0 Protein of unknown function Arrestin_N PF00339.29 EMD61880.1 - 8e-17 61.7 0.2 8e-16 58.4 0.0 2.7 3 1 0 3 3 3 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 EMD61880.1 - 9.7e-11 42.3 0.0 1.6e-06 28.6 0.0 2.4 2 0 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain FCH PF00611.23 EMD61881.1 - 0.0036 17.5 1.5 0.062 13.6 0.3 2.3 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain Viral_env_E26 PF11050.8 EMD61881.1 - 0.008 15.6 0.1 0.01 15.2 0.1 1.2 1 0 0 1 1 1 1 Virus envelope protein E26 CHASE3 PF05227.13 EMD61881.1 - 0.018 15.0 6.8 0.026 14.5 6.8 1.3 1 0 0 1 1 1 0 CHASE3 domain Bap31_Bap29_C PF18035.1 EMD61881.1 - 0.019 15.0 1.3 0.019 15.0 1.3 1.9 2 0 0 2 2 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain YjcZ PF13990.6 EMD61881.1 - 0.2 11.0 4.4 0.36 10.2 3.9 1.6 1 1 1 2 2 2 0 YjcZ-like protein G-patch PF01585.23 EMD61882.1 - 9.5e-07 28.6 0.0 7.1e-06 25.8 0.0 2.3 1 1 0 1 1 1 1 G-patch domain GREB1 PF15782.5 EMD61882.1 - 0.17 8.9 18.0 0.22 8.6 18.0 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer G-patch_2 PF12656.7 EMD61882.1 - 0.18 11.9 0.0 0.18 11.9 0.0 3.7 5 0 0 5 5 5 0 G-patch domain CRT10 PF08728.10 EMD61882.1 - 0.47 8.6 12.0 0.63 8.1 12.0 1.2 1 0 0 1 1 1 0 CRT10 Macoilin PF09726.9 EMD61882.1 - 1.6 7.2 23.1 2.1 6.8 23.1 1.2 1 0 0 1 1 1 0 Macoilin family MCLC PF05934.11 EMD61882.1 - 1.9 7.1 12.1 2.5 6.7 12.1 1.2 1 0 0 1 1 1 0 Mid-1-related chloride channel (MCLC) Asp-B-Hydro_N PF05279.11 EMD61882.1 - 5.5 7.0 28.9 0.28 11.2 23.5 1.5 2 0 0 2 2 2 0 Aspartyl beta-hydroxylase N-terminal region Menin PF05053.13 EMD61882.1 - 6.2 5.0 18.8 9.2 4.5 18.8 1.2 1 0 0 1 1 1 0 Menin CDC45 PF02724.14 EMD61882.1 - 7.2 4.8 28.6 11 4.1 28.6 1.4 1 0 0 1 1 1 0 CDC45-like protein LAP1C PF05609.12 EMD61882.1 - 9.1 5.2 24.5 13 4.8 24.5 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) GHMP_kinases_N PF00288.26 EMD61883.1 - 2.4e-15 56.5 0.1 6.4e-15 55.1 0.1 1.8 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 EMD61883.1 - 1.4e-08 35.0 0.0 3.4e-08 33.7 0.0 1.6 1 0 0 1 1 1 1 GHMP kinases C terminal GalKase_gal_bdg PF10509.9 EMD61883.1 - 0.018 14.6 0.1 0.038 13.6 0.1 1.5 1 0 0 1 1 1 0 Galactokinase galactose-binding signature eIF3_subunit PF08597.10 EMD61884.1 - 7.8e-67 225.7 30.1 9e-67 225.5 30.1 1.0 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit Phage_GPD PF05954.11 EMD61884.1 - 0.024 14.0 4.7 0.036 13.4 4.7 1.2 1 0 0 1 1 1 0 Phage late control gene D protein (GPD) HisG PF01634.18 EMD61885.1 - 1.1e-55 187.9 0.1 1.6e-55 187.5 0.1 1.2 1 0 0 1 1 1 1 ATP phosphoribosyltransferase HisG_C PF08029.11 EMD61885.1 - 2e-27 95.1 0.2 4.3e-27 94.1 0.2 1.6 1 0 0 1 1 1 1 HisG, C-terminal domain NMT1 PF09084.11 EMD61885.1 - 0.0065 16.4 0.1 0.019 14.9 0.1 1.8 1 1 0 1 1 1 1 NMT1/THI5 like P22_Cro PF14549.6 EMD61885.1 - 0.17 11.7 0.2 0.38 10.6 0.2 1.5 1 0 0 1 1 1 0 DNA-binding transcriptional regulator Cro MutS_V PF00488.21 EMD61886.1 - 2.8e-64 216.6 0.6 4.8e-64 215.9 0.6 1.4 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 EMD61886.1 - 5.1e-33 114.9 1.2 1.3e-32 113.6 1.2 1.7 1 0 0 1 1 1 1 MutS domain III MutS_II PF05188.17 EMD61886.1 - 5.7e-10 39.6 0.1 1.7e-09 38.1 0.1 1.8 1 0 0 1 1 1 1 MutS domain II MutS_IV PF05190.18 EMD61886.1 - 1e-06 29.0 0.2 2.5e-06 27.7 0.2 1.7 1 0 0 1 1 1 1 MutS family domain IV AAA_27 PF13514.6 EMD61886.1 - 0.021 14.4 0.0 1.4 8.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain WD40 PF00400.32 EMD61887.1 - 1.2e-60 200.0 32.6 2.6e-10 40.7 0.2 9.4 8 1 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD61887.1 - 1.9e-22 79.3 0.6 7.8e-05 22.9 0.0 6.2 3 2 1 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EMD61887.1 - 2.9e-05 23.2 0.1 0.41 9.5 0.0 4.4 4 1 1 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein NLE PF08154.12 EMD61887.1 - 0.0003 21.3 0.1 0.00068 20.1 0.1 1.6 1 0 0 1 1 1 1 NLE (NUC135) domain Nbas_N PF15492.6 EMD61887.1 - 0.00031 20.2 0.1 11 5.2 0.0 4.1 3 1 1 4 4 4 1 Neuroblastoma-amplified sequence, N terminal Nup160 PF11715.8 EMD61887.1 - 0.0016 17.2 6.9 1.8 7.1 0.1 4.6 4 2 1 5 5 5 2 Nucleoporin Nup120/160 PD40 PF07676.12 EMD61887.1 - 0.0036 17.2 1.4 7.4 6.6 0.0 4.4 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat TFIIIC_delta PF12657.7 EMD61887.1 - 0.016 15.1 0.2 14 5.6 0.0 3.5 3 1 1 4 4 4 0 Transcription factor IIIC subunit delta N-term DUF4550 PF15084.6 EMD61887.1 - 0.11 12.9 0.3 0.84 10.1 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4550) Proteasome_A_N PF10584.9 EMD61887.1 - 0.15 11.8 1.8 28 4.5 0.1 4.1 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature PsaD PF02531.16 EMD61887.1 - 0.17 11.4 0.0 0.42 10.1 0.0 1.7 1 1 0 1 1 1 0 PsaD WD40_like PF17005.5 EMD61887.1 - 0.21 10.9 0.0 1.2e+02 1.9 0.0 3.6 3 1 1 4 4 4 0 WD40-like domain C2 PF00168.30 EMD61888.1 - 5e-24 84.6 0.0 2e-11 44.0 0.0 2.6 2 0 0 2 2 2 2 C2 domain Aminotran_3 PF00202.21 EMD61889.1 - 2.1e-118 395.5 0.0 2.4e-118 395.3 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Beta_elim_lyase PF01212.21 EMD61889.1 - 0.00025 20.4 0.0 0.00062 19.1 0.0 1.6 2 0 0 2 2 2 1 Beta-eliminating lyase Aminotran_1_2 PF00155.21 EMD61889.1 - 0.0016 17.7 0.0 0.0025 17.0 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II UPF0556 PF10572.9 EMD61889.1 - 0.1 12.1 0.3 0.3 10.6 0.0 1.8 2 0 0 2 2 2 0 Uncharacterised protein family UPF0556 ABC_membrane PF00664.23 EMD61890.1 - 5.1e-55 187.0 38.2 1.7e-37 129.6 18.4 3.2 3 0 0 3 3 3 3 ABC transporter transmembrane region ABC_tran PF00005.27 EMD61890.1 - 2.3e-49 167.5 1.1 4.6e-28 98.4 0.0 2.9 3 0 0 3 3 2 2 ABC transporter Zeta_toxin PF06414.12 EMD61890.1 - 2.3e-06 27.0 0.0 0.00026 20.3 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin MMR_HSR1 PF01926.23 EMD61890.1 - 7e-06 26.1 2.9 0.039 14.0 0.1 3.4 3 0 0 3 3 3 2 50S ribosome-binding GTPase SMC_N PF02463.19 EMD61890.1 - 1.4e-05 24.6 6.7 0.3 10.5 0.1 3.8 3 1 0 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EMD61890.1 - 3e-05 23.6 0.9 0.11 12.3 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_21 PF13304.6 EMD61890.1 - 4.2e-05 23.5 0.1 0.39 10.5 0.0 2.9 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 EMD61890.1 - 6.8e-05 23.3 0.1 0.14 12.5 0.0 2.7 2 0 0 2 2 2 2 AAA ATPase domain AAA_30 PF13604.6 EMD61890.1 - 0.00044 20.0 2.7 0.37 10.5 0.0 3.4 4 0 0 4 4 4 2 AAA domain RsgA_GTPase PF03193.16 EMD61890.1 - 0.00075 19.4 1.1 0.36 10.7 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase AAA_23 PF13476.6 EMD61890.1 - 0.00076 20.0 9.4 0.17 12.4 0.2 3.4 3 0 0 3 3 3 2 AAA domain DUF87 PF01935.17 EMD61890.1 - 0.0051 16.9 3.6 0.16 12.1 0.3 2.7 2 0 0 2 2 2 1 Helicase HerA, central domain TrwB_AAD_bind PF10412.9 EMD61890.1 - 0.012 14.5 0.3 0.87 8.4 0.0 2.4 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain IstB_IS21 PF01695.17 EMD61890.1 - 0.017 14.8 0.0 2.3 7.9 0.0 2.5 2 0 0 2 2 2 0 IstB-like ATP binding protein Ploopntkinase3 PF18751.1 EMD61890.1 - 0.038 13.9 0.3 8.2 6.3 0.0 2.5 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 Roc PF08477.13 EMD61890.1 - 0.052 13.8 0.1 14 6.0 0.0 3.0 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_7 PF12775.7 EMD61890.1 - 0.061 12.8 0.4 2.1 7.8 0.1 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region Dynamin_N PF00350.23 EMD61890.1 - 0.083 12.9 10.4 0.59 10.2 0.5 3.2 3 0 0 3 3 3 0 Dynamin family AAA_22 PF13401.6 EMD61890.1 - 0.087 13.1 1.3 21 5.4 0.2 3.1 2 1 0 2 2 2 0 AAA domain Coilin_N PF15862.5 EMD61890.1 - 0.11 12.3 10.0 0.093 12.5 7.5 2.1 2 1 0 2 2 1 0 Coilin N-terminus AAA_28 PF13521.6 EMD61890.1 - 0.13 12.5 0.0 0.13 12.5 0.0 3.1 4 0 0 4 4 3 0 AAA domain MeaB PF03308.16 EMD61890.1 - 0.19 10.7 4.1 1.8 7.5 0.1 2.8 3 0 0 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_15 PF13175.6 EMD61890.1 - 0.19 11.4 1.7 8.7 5.9 0.4 2.9 2 1 0 2 2 2 0 AAA ATPase domain SPAN-X PF07458.12 EMD61890.1 - 1 9.9 9.3 0.14 12.7 3.3 2.4 3 0 0 3 3 2 0 Sperm protein associated with nucleus, mapped to X chromosome ATP_bind_1 PF03029.17 EMD61890.1 - 7.3 6.3 6.7 31 4.2 0.1 3.4 4 0 0 4 4 4 0 Conserved hypothetical ATP binding protein NB-ARC PF00931.22 EMD61890.1 - 9.8 5.3 10.0 14 4.8 0.2 3.6 4 0 0 4 4 4 0 NB-ARC domain FANCI_HD1 PF14679.6 EMD61892.1 - 0.09 12.8 0.2 0.19 11.7 0.2 1.6 1 1 0 1 1 1 0 FANCI helical domain 1 Gamma-thionin PF00304.20 EMD61893.1 - 0.018 15.3 18.7 0.34 11.2 4.2 2.3 2 0 0 2 2 2 0 Gamma-thionin family Prokineticin PF06607.11 EMD61893.1 - 0.095 13.0 0.5 0.095 13.0 0.5 2.7 2 1 1 3 3 3 0 Prokineticin Nodulin_late PF07127.11 EMD61893.1 - 0.43 10.9 5.3 11 6.5 0.1 2.2 2 0 0 2 2 2 0 Late nodulin protein DND1_DSRM PF14709.7 EMD61894.1 - 0.029 14.6 1.1 0.078 13.3 0.9 1.9 1 1 0 1 1 1 0 double strand RNA binding domain from DEAD END PROTEIN 1 Gram_pos_anchor PF00746.21 EMD61896.1 - 1.1 9.2 8.5 0.88 9.6 3.1 2.3 2 0 0 2 2 2 0 LPXTG cell wall anchor motif DNA_pol_E_B PF04042.16 EMD61897.1 - 2.2e-41 141.6 0.0 3e-41 141.1 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B DNA_pol_D_N PF18018.1 EMD61897.1 - 5.7e-37 126.7 0.0 9e-37 126.1 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase delta subunit OB-fold domain Claudin_2 PF13903.6 EMD61898.1 - 4.2e-05 23.4 1.1 0.0082 15.9 0.0 2.1 2 0 0 2 2 2 2 PMP-22/EMP/MP20/Claudin tight junction Lipase_3 PF01764.25 EMD61899.1 - 7e-33 113.5 0.0 1.1e-32 112.8 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) DUF2974 PF11187.8 EMD61899.1 - 0.0011 18.5 0.0 0.0055 16.3 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF2974) Hydrolase_4 PF12146.8 EMD61899.1 - 0.0014 18.0 0.0 0.0021 17.4 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EMD61899.1 - 0.0027 18.4 0.0 0.0038 17.9 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EMD61899.1 - 0.026 14.2 0.0 0.042 13.5 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold PGAP1 PF07819.13 EMD61899.1 - 0.045 13.5 0.0 0.078 12.7 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein Esterase PF00756.20 EMD61899.1 - 0.056 13.1 0.0 0.094 12.3 0.0 1.3 1 0 0 1 1 1 0 Putative esterase Cutinase PF01083.22 EMD61899.1 - 0.089 12.7 0.0 0.17 11.8 0.0 1.5 1 1 0 1 1 1 0 Cutinase DUF676 PF05057.14 EMD61899.1 - 0.12 11.9 0.0 0.18 11.3 0.0 1.2 1 0 0 1 1 1 0 Putative serine esterase (DUF676) Abhydrolase_5 PF12695.7 EMD61899.1 - 0.21 11.4 0.0 0.36 10.6 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family DAHP_synth_1 PF00793.20 EMD61900.1 - 2.3e-101 338.3 0.1 2.9e-101 338.0 0.1 1.0 1 0 0 1 1 1 1 DAHP synthetase I family AP_endonuc_2 PF01261.24 EMD61901.1 - 4.5e-35 121.0 0.0 5.7e-35 120.7 0.0 1.1 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel adh_short PF00106.25 EMD61902.1 - 4.4e-39 134.0 0.0 2.3e-25 89.2 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EMD61902.1 - 1e-35 123.4 0.1 1.8e-15 57.2 0.0 3.0 2 1 1 3 3 3 3 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD61902.1 - 5.2e-05 23.2 0.0 8.3e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 EMD61902.1 - 0.0013 18.2 0.0 1.2 8.5 0.0 2.1 2 0 0 2 2 2 2 Fungal family of unknown function (DUF1776) Rad60-SLD PF11976.8 EMD61903.1 - 4e-23 81.0 0.0 2.1e-19 69.1 0.0 2.5 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 EMD61903.1 - 9.3e-07 28.5 0.0 5.7e-06 26.0 0.0 2.0 2 0 0 2 2 2 1 Ubiquitin family LSM PF01423.22 EMD61904.1 - 1.6e-19 69.3 0.0 1.8e-19 69.2 0.0 1.0 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EMD61904.1 - 0.00089 19.4 0.0 0.0011 19.0 0.0 1.1 1 0 0 1 1 1 1 Ataxin 2 SM domain LSM14 PF12701.7 EMD61904.1 - 0.011 15.9 0.1 0.012 15.7 0.1 1.2 1 0 0 1 1 1 0 Scd6-like Sm domain Attractin PF08037.11 EMD61905.1 - 0.00061 19.7 0.6 0.0014 18.6 0.6 1.6 1 0 0 1 1 1 1 Attractin family p450 PF00067.22 EMD61906.1 - 3.4e-26 92.0 0.0 4.4e-26 91.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 EMD61907.1 - 1.2e-33 116.5 0.0 1.7e-33 116.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 PsiA PF06952.11 EMD61908.1 - 1.3 8.2 7.9 3.2 6.9 5.3 2.2 2 0 0 2 2 2 0 PsiA protein DUF4519 PF15012.6 EMD61908.1 - 6.9 6.9 13.6 20 5.4 13.6 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4519) NARP1 PF12569.8 EMD61908.1 - 7.2 5.4 13.9 1.5 7.7 9.6 1.8 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 E1-E2_ATPase PF00122.20 EMD61909.1 - 8.4e-53 178.6 3.1 9.5e-52 175.1 1.2 2.8 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 EMD61909.1 - 4.9e-46 156.7 6.0 9.4e-46 155.8 6.0 1.5 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.6 EMD61909.1 - 7.7e-22 77.2 0.0 1.5e-21 76.2 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EMD61909.1 - 8.7e-22 78.4 1.5 6.4e-21 75.6 1.5 2.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EMD61909.1 - 1.2e-19 69.7 0.1 4.3e-19 68.0 0.0 2.1 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EMD61909.1 - 1.9e-08 34.4 0.5 1.9e-06 27.8 0.8 2.5 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 EMD61909.1 - 5.4e-07 30.2 0.0 1.4e-06 28.8 0.0 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Response_reg PF00072.24 EMD61910.1 - 4.5e-20 71.9 0.1 1.1e-19 70.6 0.1 1.7 1 0 0 1 1 1 1 Response regulator receiver domain HATPase_c PF02518.26 EMD61910.1 - 1.9e-18 67.0 0.0 5.2e-18 65.6 0.0 1.8 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 EMD61910.1 - 7.4e-06 25.9 0.1 2.3e-05 24.3 0.1 1.8 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain AvrM-A PF18241.1 EMD61910.1 - 0.085 13.3 0.0 0.19 12.1 0.0 1.5 1 0 0 1 1 1 0 Flax-rust effector AvrM-A Stk19 PF10494.9 EMD61911.1 - 2.1e-67 227.4 0.0 2.6e-67 227.1 0.0 1.1 1 0 0 1 1 1 1 Serine-threonine protein kinase 19 DAGAT PF03982.13 EMD61912.1 - 7.5e-99 330.4 0.0 1e-98 330.0 0.0 1.1 1 0 0 1 1 1 1 Diacylglycerol acyltransferase Rer1 PF03248.13 EMD61912.1 - 0.11 12.2 0.0 0.21 11.3 0.0 1.4 1 0 0 1 1 1 0 Rer1 family adh_short_C2 PF13561.6 EMD61914.1 - 9e-49 166.1 0.1 1.1e-48 165.8 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EMD61914.1 - 1.5e-36 125.7 0.4 1.9e-36 125.4 0.4 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EMD61914.1 - 5.4e-06 26.4 0.3 8.4e-06 25.8 0.3 1.3 1 0 0 1 1 1 1 KR domain NAD_binding_7 PF13241.6 EMD61914.1 - 0.028 14.9 0.7 0.053 14.0 0.6 1.5 1 1 0 1 1 1 0 Putative NAD(P)-binding Pyr_redox PF00070.27 EMD61914.1 - 0.032 14.8 0.4 0.36 11.4 0.3 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 EMD61914.1 - 0.082 12.8 0.2 0.2 11.5 0.2 1.7 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DUF2884 PF11101.8 EMD61914.1 - 0.12 11.8 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2884) Esterase PF00756.20 EMD61915.1 - 8.6e-08 32.1 0.0 1.6e-07 31.3 0.0 1.4 1 1 0 1 1 1 1 Putative esterase Peptidase_S9 PF00326.21 EMD61915.1 - 0.00022 20.8 0.0 0.0004 19.9 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 EMD61915.1 - 0.0032 16.8 0.0 0.0045 16.3 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 COesterase PF00135.28 EMD61916.1 - 4.2e-86 289.9 0.0 6.4e-76 256.3 0.1 2.0 1 1 1 2 2 2 2 Carboxylesterase family Abhydrolase_3 PF07859.13 EMD61916.1 - 2.7e-12 47.0 0.1 5.1e-12 46.1 0.1 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EMD61916.1 - 0.023 14.1 0.1 0.04 13.4 0.1 1.4 1 0 0 1 1 1 0 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 EMD61916.1 - 0.11 13.1 9.0 0.34 11.5 9.0 2.0 1 1 0 1 1 1 0 Alpha/beta hydrolase family Conotoxin PF02950.17 EMD61918.1 - 0.00065 20.7 1.2 0.00088 20.2 1.2 1.3 1 0 0 1 1 1 1 Conotoxin Slx4 PF09494.10 EMD61918.1 - 2.1 8.3 4.6 9.4 6.3 4.6 2.0 1 1 0 1 1 1 0 Slx4 endonuclease HeLo PF14479.6 EMD61919.1 - 6.5e-35 120.8 0.0 4e-34 118.3 0.0 2.0 2 0 0 2 2 2 1 Prion-inhibition and propagation T6SS-SciN PF12790.7 EMD61919.1 - 0.008 15.9 0.1 1.5 8.6 0.0 2.4 2 0 0 2 2 2 2 Type VI secretion lipoprotein, VasD, EvfM, TssJ, VC_A0113 TPR_12 PF13424.6 EMD61920.1 - 3.1e-54 181.2 36.0 6.4e-10 39.2 0.6 5.2 1 1 6 7 7 7 7 Tetratricopeptide repeat TPR_10 PF13374.6 EMD61920.1 - 1.4e-39 132.9 28.2 0.0001 22.0 0.2 8.9 8 0 0 8 8 8 8 Tetratricopeptide repeat TPR_2 PF07719.17 EMD61920.1 - 6.5e-24 82.1 0.0 0.1 12.8 0.0 9.0 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_20 PF14561.6 EMD61920.1 - 4.7e-20 71.7 17.2 0.055 13.8 0.1 8.7 2 1 6 8 8 8 6 Tetratricopeptide repeat ANAPC3 PF12895.7 EMD61920.1 - 4.3e-18 65.3 5.6 0.012 15.9 0.0 7.3 1 1 6 7 7 7 5 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 EMD61920.1 - 1.2e-14 53.9 0.3 1 10.2 0.0 8.1 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_14 PF13428.6 EMD61920.1 - 1.9e-14 53.1 4.0 0.67 10.9 0.0 8.3 2 2 5 7 7 7 2 Tetratricopeptide repeat TPR_19 PF14559.6 EMD61920.1 - 2.1e-13 50.6 15.6 0.02 15.4 0.1 6.7 4 1 4 8 8 6 5 Tetratricopeptide repeat TPR_8 PF13181.6 EMD61920.1 - 9.8e-13 47.2 0.1 3.4 8.1 0.0 8.1 8 0 0 8 8 7 1 Tetratricopeptide repeat HET PF06985.11 EMD61920.1 - 1.4e-11 44.9 4.2 6.3e-09 36.3 0.1 3.0 1 1 0 2 2 2 2 Heterokaryon incompatibility protein (HET) TPR_1 PF00515.28 EMD61920.1 - 1.5e-09 37.3 0.0 6 6.9 0.0 7.6 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_4 PF07721.14 EMD61920.1 - 6.3e-09 35.6 28.4 2.1 9.2 0.1 8.8 8 0 0 8 8 7 3 Tetratricopeptide repeat PPR PF01535.20 EMD61920.1 - 1.1e-08 34.7 0.0 16 6.1 0.0 8.1 8 0 0 8 8 8 0 PPR repeat NB-ARC PF00931.22 EMD61920.1 - 3e-08 33.1 0.0 5.2e-08 32.4 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain TPR_16 PF13432.6 EMD61920.1 - 2.5e-07 31.2 1.6 3.6 8.3 0.0 7.1 6 2 2 8 8 8 1 Tetratricopeptide repeat PPR_1 PF12854.7 EMD61920.1 - 3.7e-07 29.7 0.1 17 5.2 0.0 6.9 7 0 0 7 7 7 0 PPR repeat MORN_2 PF07661.13 EMD61920.1 - 1.3e-06 28.0 0.4 56 4.4 0.0 7.1 7 0 0 7 7 7 0 MORN repeat variant TPR_17 PF13431.6 EMD61920.1 - 2.4e-06 27.5 5.5 17 6.0 0.0 7.5 7 0 0 7 7 7 0 Tetratricopeptide repeat ATP13 PF12921.7 EMD61920.1 - 3.1e-06 27.0 0.0 8 6.4 0.0 6.4 1 1 2 5 5 5 0 Mitochondrial ATPase expression VWA_3_C PF18571.1 EMD61920.1 - 4.4e-06 26.5 13.6 29 4.6 0.0 7.5 7 0 0 7 7 7 0 von Willebrand factor type A C-terminal domain TPR_7 PF13176.6 EMD61920.1 - 8e-06 25.5 7.3 2.4 8.4 0.0 6.8 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_5 PF12688.7 EMD61920.1 - 0.00022 21.4 11.0 3.8 7.8 0.1 6.7 2 1 6 8 8 8 1 Tetratrico peptide repeat AAA_22 PF13401.6 EMD61920.1 - 0.0007 19.9 0.0 0.0028 18.0 0.0 2.0 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 EMD61920.1 - 0.00096 19.1 0.0 0.0022 17.9 0.0 1.7 1 0 0 1 1 1 1 NACHT domain WbqC PF08889.11 EMD61920.1 - 0.0012 18.8 3.6 11 5.8 0.2 4.0 1 1 2 4 4 4 0 WbqC-like protein family AAA_16 PF13191.6 EMD61920.1 - 0.0067 16.8 1.5 0.0067 16.8 1.5 3.5 2 2 0 2 2 2 1 AAA ATPase domain HTH_3 PF01381.22 EMD61920.1 - 0.017 15.1 0.1 0.1 12.7 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix Glyco_hydro_115 PF15979.5 EMD61920.1 - 0.23 10.8 2.7 16 4.8 0.1 3.2 1 1 1 3 3 3 0 Glycosyl hydrolase family 115 zf-C2H2_3rep PF18868.1 EMD61920.1 - 3.6 8.3 5.8 4 8.1 0.5 3.3 2 1 3 5 5 5 0 Zinc finger C2H2-type, 3 repeats Peptidase_M50B PF13398.6 EMD61921.1 - 1.1e-59 201.5 18.2 1.3e-59 201.2 18.2 1.1 1 0 0 1 1 1 1 Peptidase M50B-like Peptidase_M50 PF02163.22 EMD61921.1 - 0.064 12.5 0.2 0.12 11.6 0.2 1.5 1 0 0 1 1 1 0 Peptidase family M50 Patched PF02460.18 EMD61921.1 - 2.5 6.1 5.2 3.8 5.4 5.2 1.3 1 0 0 1 1 1 0 Patched family Sugar_tr PF00083.24 EMD61922.1 - 3.3e-128 428.4 18.4 3.7e-128 428.2 18.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD61922.1 - 6.9e-23 81.1 36.8 1.4e-16 60.4 9.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2530 PF10745.9 EMD61922.1 - 0.022 15.0 1.4 0.022 15.0 1.4 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF2530) Zn_clus PF00172.18 EMD61923.1 - 8.6e-07 29.0 8.7 1.9e-06 27.9 8.7 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EMD61923.1 - 0.00049 19.2 0.0 0.00089 18.4 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain FmiP_Thoc5 PF09766.9 EMD61925.1 - 3.2e-21 76.0 14.6 3.2e-21 76.0 14.6 2.0 1 1 1 2 2 2 1 Fms-interacting protein/Thoc5 DUF349 PF03993.12 EMD61925.1 - 1.4 9.3 10.9 0.061 13.6 3.6 2.4 2 1 0 2 2 2 0 Domain of Unknown Function (DUF349) DUF1542 PF07564.11 EMD61925.1 - 2.4 8.3 8.9 12 6.1 1.0 2.9 2 1 1 3 3 3 0 Domain of Unknown Function (DUF1542) U3_snoRNA_assoc PF08297.11 EMD61925.1 - 9.7 7.0 11.1 0.87 10.3 3.2 2.4 2 0 0 2 2 2 0 U3 snoRNA associated SNF2_N PF00176.23 EMD61926.1 - 1.8e-58 198.0 0.0 3.2e-58 197.1 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain zf-C3HC4_2 PF13923.6 EMD61926.1 - 9.2e-10 38.2 8.6 2.9e-09 36.6 8.6 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMD61926.1 - 1.7e-08 34.2 9.8 4.4e-08 32.9 9.8 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EMD61926.1 - 5e-08 32.7 7.8 1.1e-07 31.6 7.8 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EMD61926.1 - 8.6e-08 32.4 10.7 8.6e-08 32.4 10.7 1.9 2 0 0 2 2 1 1 Ring finger domain Prok-RING_4 PF14447.6 EMD61926.1 - 9.7e-06 25.4 7.4 2.3e-05 24.2 7.4 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 EMD61926.1 - 2.4e-05 24.5 8.6 7.4e-05 23.0 8.6 1.9 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 EMD61926.1 - 3e-05 24.0 5.1 7.2e-05 22.7 5.1 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 EMD61926.1 - 7.8e-05 22.6 9.2 0.00018 21.4 9.2 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 EMD61926.1 - 0.0037 17.4 7.6 0.0086 16.2 7.6 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Helicase_C PF00271.31 EMD61926.1 - 0.015 15.6 0.0 0.046 14.1 0.0 1.9 1 0 0 1 1 1 0 Helicase conserved C-terminal domain Baculo_IE-1 PF05290.11 EMD61926.1 - 0.098 12.6 3.7 0.23 11.4 3.7 1.5 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) zf-ANAPC11 PF12861.7 EMD61926.1 - 0.2 11.7 3.1 0.46 10.6 3.1 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger KxDL PF10241.9 EMD61926.1 - 0.33 11.3 3.0 1.1 9.6 3.0 1.8 1 0 0 1 1 1 0 Uncharacterized conserved protein zf-RING_4 PF14570.6 EMD61926.1 - 2.6 7.9 10.6 0.31 10.9 5.2 2.3 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain Cor1 PF04803.12 EMD61926.1 - 2.8 8.2 13.2 0.19 11.9 3.2 3.3 3 0 0 3 3 3 0 Cor1/Xlr/Xmr conserved region zf-RING_10 PF16685.5 EMD61926.1 - 3.8 7.7 9.9 4.1 7.6 7.8 2.2 2 1 0 2 2 2 0 zinc RING finger of MSL2 DUF16 PF01519.16 EMD61926.1 - 8.4 6.9 8.7 1 9.9 2.4 2.5 2 1 0 2 2 2 0 Protein of unknown function DUF16 MGC-24 PF05283.11 EMD61927.1 - 0.0015 19.0 4.2 0.0015 19.0 4.2 2.5 1 1 1 2 2 2 1 Multi-glycosylated core protein 24 (MGC-24), sialomucin Sod_Fe_C PF02777.18 EMD61928.1 - 6.2e-19 68.1 0.1 4.9e-08 33.1 0.1 2.6 3 0 0 3 3 3 2 Iron/manganese superoxide dismutases, C-terminal domain DNA_Packaging PF11053.8 EMD61929.1 - 0.058 13.2 0.1 0.11 12.3 0.1 1.3 1 0 0 1 1 1 0 Terminase DNA packaging enzyme AIF_C PF14721.6 EMD61929.1 - 2.7 8.4 4.2 2.5 8.5 0.1 2.5 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term RhoGAP PF00620.27 EMD61931.1 - 4.8e-42 143.3 0.1 9.6e-42 142.4 0.1 1.5 1 0 0 1 1 1 1 RhoGAP domain PH PF00169.29 EMD61931.1 - 3.3e-15 56.5 0.1 7e-15 55.4 0.1 1.6 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 EMD61931.1 - 8.7e-07 29.3 0.0 1.8e-06 28.3 0.0 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.6 EMD61931.1 - 0.0087 16.3 0.1 0.075 13.3 0.0 2.2 2 0 0 2 2 2 1 Pleckstrin homology domain Host_attach PF10116.9 EMD61931.1 - 0.82 10.2 7.8 0.33 11.5 0.1 3.2 2 1 1 3 3 3 0 Protein required for attachment to host cells Ribosomal_S13 PF00416.22 EMD61932.1 - 2.2e-19 70.1 1.9 1.8e-17 63.9 1.9 2.0 1 1 0 1 1 1 1 Ribosomal protein S13/S18 IMS_HHH PF11798.8 EMD61932.1 - 0.13 12.6 0.0 0.39 11.2 0.0 1.8 1 0 0 1 1 1 0 IMS family HHH motif Pro_isomerase PF00160.21 EMD61933.1 - 3.4e-49 167.1 0.5 4.2e-49 166.8 0.5 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD DEAD PF00270.29 EMD61934.1 - 1.6e-47 161.6 0.0 2.6e-47 160.8 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EMD61934.1 - 1.9e-31 108.7 0.0 4.2e-31 107.6 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EMD61934.1 - 0.0021 18.1 0.0 0.0034 17.4 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 EMD61934.1 - 0.079 12.3 0.0 0.13 11.5 0.0 1.2 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit An_peroxidase PF03098.15 EMD61935.1 - 2.2e-37 128.9 0.0 2.1e-21 76.1 0.0 3.4 1 1 2 3 3 3 3 Animal haem peroxidase p450 PF00067.22 EMD61935.1 - 2.2e-09 36.6 0.1 9.9e-08 31.1 0.0 2.1 2 0 0 2 2 2 2 Cytochrome P450 Secretogranin_V PF05281.11 EMD61935.1 - 0.011 15.3 0.0 0.02 14.5 0.0 1.3 1 0 0 1 1 1 0 Neuroendocrine protein 7B2 precursor (Secretogranin V) DUF2235 PF09994.9 EMD61936.1 - 4.2e-102 341.4 1.4 7e-102 340.6 1.4 1.4 1 1 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) Glyco_hydro_61 PF03443.14 EMD61937.1 - 5.7e-62 209.3 0.1 8.2e-62 208.8 0.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 CBM_1 PF00734.18 EMD61937.1 - 2e-09 37.2 11.7 2.1e-09 37.2 9.5 2.3 2 0 0 2 2 2 1 Fungal cellulose binding domain WSC PF01822.19 EMD61938.1 - 2.1e-08 34.2 0.4 2.1e-08 34.2 0.4 2.4 2 1 0 2 2 2 1 WSC domain GFO_IDH_MocA PF01408.22 EMD61939.1 - 9.6e-18 65.2 0.0 1.6e-17 64.5 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold NAD_binding_3 PF03447.16 EMD61939.1 - 0.063 13.9 0.0 0.1 13.2 0.0 1.2 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain GFO_IDH_MocA_C PF02894.17 EMD61939.1 - 0.081 12.9 0.0 0.16 12.0 0.0 1.5 1 0 0 1 1 1 0 Oxidoreductase family, C-terminal alpha/beta domain Fungal_trans PF04082.18 EMD61940.1 - 1.4e-19 70.2 0.0 3.3e-19 69.0 0.0 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD61940.1 - 0.0021 18.1 14.7 0.0042 17.2 14.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SelP_N PF04592.14 EMD61940.1 - 3.4 7.0 7.8 5.9 6.2 7.8 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region DUF637 PF04830.13 EMD61941.1 - 0.047 13.5 0.5 0.067 13.0 0.5 1.4 1 1 0 1 1 1 0 Possible hemagglutinin (DUF637) AAA_5 PF07728.14 EMD61941.1 - 0.055 13.5 0.6 0.091 12.8 0.6 1.5 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) ThiS PF02597.20 EMD61941.1 - 0.87 10.3 4.1 1.7 9.3 0.2 2.5 1 1 1 2 2 2 0 ThiS family Phage_GP20 PF06810.11 EMD61941.1 - 4.5 7.1 11.5 75 3.1 10.7 2.2 1 1 0 1 1 1 0 Phage minor structural protein GP20 Clathrin PF00637.20 EMD61943.1 - 1.1e-197 647.9 32.1 2.9e-34 118.0 1.4 7.9 8 0 0 8 8 8 7 Region in Clathrin and VPS Clathrin_H_link PF13838.6 EMD61943.1 - 6e-29 99.8 2.5 2.1e-28 98.0 0.1 3.3 3 1 1 4 4 4 1 Clathrin-H-link Clathrin_propel PF01394.20 EMD61943.1 - 1.3e-11 44.2 0.6 8.1e-05 22.7 0.1 4.6 4 0 0 4 4 4 2 Clathrin propeller repeat TPR_14 PF13428.6 EMD61943.1 - 5.9e-06 26.7 10.0 0.24 12.3 0.1 8.1 8 0 0 8 8 8 1 Tetratricopeptide repeat Vps39_1 PF10366.9 EMD61943.1 - 3.4e-05 24.1 5.4 1.1 9.6 0.0 5.6 5 1 0 6 6 6 2 Vacuolar sorting protein 39 domain 1 TPR_2 PF07719.17 EMD61943.1 - 0.0012 18.8 1.8 6.1 7.2 0.0 5.7 5 0 0 5 5 5 1 Tetratricopeptide repeat Coatomer_WDAD PF04053.14 EMD61943.1 - 0.022 13.8 1.6 0.53 9.3 0.4 3.4 3 0 0 3 3 3 0 Coatomer WD associated region TPR_7 PF13176.6 EMD61943.1 - 0.025 14.6 4.8 85 3.5 0.0 6.9 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_19 PF14559.6 EMD61943.1 - 0.047 14.2 0.9 36 5.0 0.1 5.0 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 EMD61943.1 - 0.057 13.3 1.6 23 5.0 0.0 4.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.6 EMD61943.1 - 0.1 12.9 7.4 1.3 9.4 0.0 5.7 6 0 0 6 6 5 0 Tetratricopeptide repeat Eisosome1 PF12757.7 EMD61944.1 - 9.7e-36 122.8 18.6 9.7e-36 122.8 18.6 3.9 3 1 1 4 4 4 1 Eisosome protein 1 Y_phosphatase3 PF13350.6 EMD61945.1 - 2.5e-42 145.4 0.0 3.3e-42 145.0 0.0 1.1 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase2 PF03162.13 EMD61945.1 - 2e-12 47.0 0.1 4e-10 39.5 0.0 2.2 2 0 0 2 2 2 2 Tyrosine phosphatase family Y_phosphatase PF00102.27 EMD61945.1 - 0.0018 17.9 0.0 0.003 17.2 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Myotub-related PF06602.14 EMD61945.1 - 0.0065 15.5 0.3 0.012 14.6 0.3 1.7 1 1 0 1 1 1 1 Myotubularin-like phosphatase domain DSPc PF00782.20 EMD61945.1 - 0.05 13.4 0.0 0.38 10.6 0.0 2.1 2 0 0 2 2 2 0 Dual specificity phosphatase, catalytic domain CMAS PF02353.20 EMD61946.1 - 1.5e-63 214.7 0.1 1.9e-63 214.4 0.1 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_11 PF08241.12 EMD61946.1 - 1.7e-10 41.4 0.0 3.8e-10 40.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EMD61946.1 - 2.8e-10 40.3 0.0 4.6e-10 39.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMD61946.1 - 5e-10 40.0 0.0 1e-09 39.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMD61946.1 - 0.00043 21.0 0.0 0.00092 19.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 EMD61946.1 - 0.0014 18.4 0.0 0.0022 17.8 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 EMD61946.1 - 0.0043 16.9 0.0 0.008 16.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain DOT1 PF08123.13 EMD61946.1 - 0.0083 15.7 0.1 0.018 14.6 0.0 1.6 2 0 0 2 2 2 1 Histone methylation protein DOT1 MTS PF05175.14 EMD61946.1 - 0.056 13.0 0.0 0.097 12.2 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain INSIG PF07281.12 EMD61947.1 - 7.6e-70 234.9 0.2 1.1e-69 234.3 0.2 1.3 1 0 0 1 1 1 1 Insulin-induced protein (INSIG) eIF2_C PF09173.11 EMD61948.1 - 1.9e-34 117.8 0.3 4.3e-34 116.6 0.3 1.7 1 0 0 1 1 1 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU PF00009.27 EMD61948.1 - 2e-23 82.9 0.1 1.2e-22 80.5 0.1 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 EMD61948.1 - 2.4e-12 47.1 0.2 5.2e-12 46.0 0.2 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EMD61948.1 - 0.004 17.2 0.0 0.0083 16.2 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EMD61948.1 - 0.0065 16.4 0.2 0.066 13.1 0.0 2.1 2 0 0 2 2 2 1 RsgA GTPase MMR_HSR1_Xtn PF16897.5 EMD61948.1 - 0.1 12.6 0.1 0.24 11.4 0.1 1.6 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain Dynamin_N PF00350.23 EMD61948.1 - 0.13 12.3 0.0 0.49 10.4 0.0 1.9 2 0 0 2 2 2 0 Dynamin family RabGAP-TBC PF00566.18 EMD61949.1 - 4.2e-23 82.1 0.0 7.4e-23 81.3 0.0 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain SBE2 PF17076.5 EMD61949.1 - 2.5e-07 29.4 3.3 1.2e-06 27.2 0.3 2.1 2 0 0 2 2 2 2 SBE2, cell-wall formation DUF4407 PF14362.6 EMD61949.1 - 0.19 11.1 1.2 0.38 10.1 1.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DiS_P_DiS PF06750.13 EMD61951.1 - 0.082 13.0 0.1 0.11 12.6 0.1 1.3 1 1 0 1 1 1 0 Bacterial Peptidase A24 N-terminal domain RhoGEF PF00621.20 EMD61953.1 - 3.6e-28 99.1 3.3 4.3e-28 98.8 0.3 2.3 2 0 0 2 2 2 1 RhoGEF domain BAR PF03114.18 EMD61953.1 - 4.1e-06 26.6 3.0 1e-05 25.3 0.1 2.6 2 1 1 3 3 3 1 BAR domain GrpE PF01025.19 EMD61953.1 - 0.14 11.8 1.1 0.32 10.6 1.1 1.5 1 0 0 1 1 1 0 GrpE Peptidase_M16_C PF05193.21 EMD61954.1 - 2e-23 83.4 0.0 3.2e-20 72.9 0.0 2.6 2 0 0 2 2 2 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EMD61954.1 - 2.5e-05 24.3 0.0 9e-05 22.5 0.0 1.9 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) DDE_Tnp_IS1 PF03400.13 EMD61954.1 - 0.019 15.3 0.0 0.055 13.8 0.0 1.7 1 0 0 1 1 1 0 IS1 transposase WD40 PF00400.32 EMD61955.1 - 3.5e-19 68.8 18.0 2.3e-05 25.1 0.3 7.5 7 0 0 7 7 7 4 WD domain, G-beta repeat NLE PF08154.12 EMD61955.1 - 4.5e-11 43.1 0.3 1.6e-10 41.3 0.3 2.0 1 0 0 1 1 1 1 NLE (NUC135) domain Zw10 PF06248.13 EMD61955.1 - 9.8e-09 34.3 3.1 6e-08 31.7 3.1 2.0 1 1 0 1 1 1 1 Centromere/kinetochore Zw10 Nup160 PF11715.8 EMD61955.1 - 1.5e-06 27.2 6.2 0.0062 15.2 0.4 3.4 1 1 1 3 3 3 3 Nucleoporin Nup120/160 Dsl1_C PF11989.8 EMD61955.1 - 2.3e-05 24.2 0.0 6.1e-05 22.8 0.0 1.7 1 0 0 1 1 1 1 Retrograde transport protein Dsl1 C terminal Trm112p PF03966.16 EMD61956.1 - 2.6e-11 43.9 0.4 1.3e-10 41.7 0.4 1.9 1 1 0 1 1 1 1 Trm112p-like protein DUF3530 PF12048.8 EMD61956.1 - 0.037 13.4 0.0 0.046 13.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3530) LRRNT PF01462.18 EMD61956.1 - 0.09 12.4 0.1 0.19 11.4 0.1 1.5 1 0 0 1 1 1 0 Leucine rich repeat N-terminal domain E7 PF00527.18 EMD61956.1 - 0.1 12.8 1.0 0.18 12.0 0.5 1.7 2 0 0 2 2 2 0 E7 protein, Early protein I-EGF_1 PF18372.1 EMD61956.1 - 0.18 11.9 1.2 0.39 10.9 1.2 1.6 1 0 0 1 1 1 0 Integrin beta epidermal growth factor like domain 1 GMC_oxred_N PF00732.19 EMD61957.1 - 9e-31 107.3 0.1 9.4e-20 71.2 0.0 3.1 2 1 1 3 3 3 3 GMC oxidoreductase GMC_oxred_C PF05199.13 EMD61957.1 - 3.4e-23 82.8 0.0 5.5e-23 82.1 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase NAD_binding_8 PF13450.6 EMD61957.1 - 0.00041 20.5 0.1 0.001 19.3 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EMD61957.1 - 0.00096 18.5 0.1 0.0038 16.5 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EMD61957.1 - 0.012 14.8 0.1 0.018 14.3 0.1 1.2 1 0 0 1 1 1 0 FAD binding domain FAD_binding_2 PF00890.24 EMD61957.1 - 0.017 14.2 0.5 0.038 13.1 0.2 1.7 2 0 0 2 2 2 0 FAD binding domain Aft1_HRA PF11786.8 EMD61957.1 - 0.07 13.5 2.6 0.38 11.1 0.3 2.5 2 0 0 2 2 2 0 Aft1 HRA domain FAD_oxidored PF12831.7 EMD61957.1 - 0.088 12.1 1.0 0.13 11.6 0.5 1.5 2 0 0 2 2 2 0 FAD dependent oxidoreductase ApbA PF02558.16 EMD61957.1 - 0.12 12.1 0.0 0.18 11.4 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Rossmann-like PF10727.9 EMD61957.1 - 0.12 12.2 0.0 0.23 11.3 0.0 1.4 1 0 0 1 1 1 0 Rossmann-like domain Pyr_redox_3 PF13738.6 EMD61957.1 - 0.13 11.5 0.0 13 4.9 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EMD61957.1 - 0.19 11.2 2.3 1.1 8.7 1.4 2.3 2 1 0 2 2 2 0 FAD dependent oxidoreductase PMM PF03332.13 EMD61958.1 - 8.6e-104 346.1 0.2 1e-103 345.9 0.2 1.0 1 0 0 1 1 1 1 Eukaryotic phosphomannomutase Hydrolase_3 PF08282.12 EMD61958.1 - 0.00054 19.8 0.0 0.0026 17.6 0.0 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 EMD61958.1 - 0.004 16.7 0.0 1.4 8.4 0.0 2.1 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase DUF2608 PF11019.8 EMD61958.1 - 0.086 12.3 0.0 0.19 11.2 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2608) DNA_pol_A_exo1 PF01612.20 EMD61959.1 - 7.4e-16 58.4 0.0 1.2e-15 57.7 0.0 1.3 1 0 0 1 1 1 1 3'-5' exonuclease LSM PF01423.22 EMD61960.1 - 2.1e-21 75.4 0.2 2.5e-21 75.1 0.2 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EMD61960.1 - 0.0032 17.6 0.0 0.0039 17.3 0.0 1.1 1 0 0 1 1 1 1 Ataxin 2 SM domain CooT PF10133.9 EMD61960.1 - 0.043 14.1 0.1 0.11 12.8 0.1 1.8 1 1 1 2 2 2 0 CO dehydrogenase accessory protein CooT DUF150_C PF17384.2 EMD61960.1 - 0.085 13.0 0.0 0.1 12.7 0.0 1.3 1 0 0 1 1 1 0 RimP C-terminal SH3 domain VWA_3_C PF18571.1 EMD61960.1 - 0.11 12.4 0.0 0.17 11.8 0.0 1.3 1 0 0 1 1 1 0 von Willebrand factor type A C-terminal domain HMG_box PF00505.19 EMD61961.1 - 8.9e-13 48.5 0.1 1.9e-12 47.4 0.1 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box SAM_1 PF00536.30 EMD61961.1 - 2e-11 44.1 0.0 4.1e-11 43.1 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) HMG_box_2 PF09011.10 EMD61961.1 - 1.1e-08 35.6 0.2 2.2e-08 34.6 0.2 1.5 1 0 0 1 1 1 1 HMG-box domain SAM_2 PF07647.17 EMD61961.1 - 5.9e-06 26.3 0.0 1.6e-05 24.9 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) DUF3074 PF11274.8 EMD61962.1 - 1.8e-37 129.1 0.2 2.4e-37 128.7 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3074) Ntox1 PF15500.6 EMD61963.1 - 0.037 14.4 1.8 0.29 11.5 1.8 2.6 1 0 0 1 1 1 0 Putative RNase-like toxin, toxin_1 NICE-3 PF07406.11 EMD61963.1 - 0.21 11.6 1.3 0.54 10.2 1.1 1.8 2 0 0 2 2 2 0 NICE-3 protein DIOX_N PF14226.6 EMD61964.1 - 2.8e-29 102.3 0.1 4.4e-29 101.6 0.1 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EMD61964.1 - 1.8e-16 60.4 0.1 4.2e-16 59.3 0.1 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF1685 PF07939.11 EMD61964.1 - 0.037 13.8 0.1 0.12 12.1 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1685) DUF3602 PF12223.8 EMD61966.1 - 3.1e-17 63.0 8.6 3.8e-13 49.8 2.0 2.5 1 1 2 3 3 3 3 Protein of unknown function (DUF3602) Sec10 PF07393.11 EMD61969.1 - 5.2e-161 537.5 0.1 7.8e-161 537.0 0.1 1.2 1 0 0 1 1 1 1 Exocyst complex component Sec10 F-box PF00646.33 EMD61969.1 - 4.1e-06 26.5 0.0 7.5e-06 25.7 0.0 1.4 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EMD61969.1 - 1e-05 25.3 0.0 2.4e-05 24.1 0.0 1.6 1 0 0 1 1 1 1 F-box-like F-box_4 PF15966.5 EMD61969.1 - 0.019 14.9 0.0 0.04 13.8 0.0 1.5 1 0 0 1 1 1 0 F-box Adenosine_kin PF04008.14 EMD61969.1 - 0.054 13.3 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 Adenosine specific kinase CppA_N PF14506.6 EMD61969.1 - 0.086 12.9 0.1 0.22 11.6 0.1 1.7 1 0 0 1 1 1 0 CppA N-terminal RPA_interact_M PF14767.6 EMD61969.1 - 0.12 12.9 0.5 0.61 10.7 0.0 2.3 2 0 0 2 2 2 0 Replication protein A interacting middle SWIB PF02201.18 EMD61970.1 - 5.6e-31 106.3 0.2 9.8e-31 105.5 0.2 1.4 1 0 0 1 1 1 1 SWIB/MDM2 domain DEK_C PF08766.11 EMD61970.1 - 3.5e-13 49.3 0.9 8.5e-13 48.0 0.9 1.7 1 0 0 1 1 1 1 DEK C terminal domain ARGLU PF15346.6 EMD61970.1 - 0.19 11.6 0.0 0.19 11.6 0.0 2.1 2 0 0 2 2 2 0 Arginine and glutamate-rich 1 SRP54_N PF02881.19 EMD61970.1 - 0.55 10.5 4.9 0.52 10.6 0.2 2.8 3 0 0 3 3 3 0 SRP54-type protein, helical bundle domain Tropomyosin_1 PF12718.7 EMD61972.1 - 2e-51 173.9 28.2 2.4e-51 173.7 28.2 1.0 1 0 0 1 1 1 1 Tropomyosin like Tropomyosin PF00261.20 EMD61972.1 - 2e-10 40.5 28.6 1.6e-06 27.6 5.1 2.9 1 1 1 2 2 2 2 Tropomyosin DUF3450 PF11932.8 EMD61972.1 - 9.8e-05 21.8 24.3 0.0047 16.3 9.9 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF3450) CENP-F_leu_zip PF10473.9 EMD61972.1 - 0.00031 20.8 27.4 0.042 13.9 9.7 3.0 2 1 1 3 3 3 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 KLRAQ PF10205.9 EMD61972.1 - 0.00053 20.2 8.8 0.00053 20.2 8.8 2.4 1 1 1 2 2 2 1 Predicted coiled-coil domain-containing protein Uso1_p115_C PF04871.13 EMD61972.1 - 0.0016 18.8 30.6 0.028 14.8 11.7 2.1 1 1 1 2 2 2 2 Uso1 / p115 like vesicle tethering protein, C terminal region DUF1664 PF07889.12 EMD61972.1 - 0.0018 18.3 15.5 0.17 11.9 2.8 2.6 2 1 1 3 3 2 2 Protein of unknown function (DUF1664) Seryl_tRNA_N PF02403.22 EMD61972.1 - 0.0029 17.8 22.9 0.22 11.7 4.7 3.1 1 1 2 3 3 3 2 Seryl-tRNA synthetase N-terminal domain TMF_TATA_bd PF12325.8 EMD61972.1 - 0.003 17.8 21.0 0.21 11.8 11.4 2.4 1 1 1 2 2 2 1 TATA element modulatory factor 1 TATA binding ADIP PF11559.8 EMD61972.1 - 0.0038 17.3 25.2 0.03 14.4 7.7 2.4 1 1 1 2 2 2 1 Afadin- and alpha -actinin-Binding HMMR_N PF15905.5 EMD61972.1 - 0.0038 16.7 29.6 0.056 12.9 10.3 2.0 1 1 1 2 2 2 2 Hyaluronan mediated motility receptor N-terminal DivIC PF04977.15 EMD61972.1 - 0.005 16.6 2.9 0.005 16.6 2.9 4.0 1 1 2 4 4 4 1 Septum formation initiator GAS PF13851.6 EMD61972.1 - 0.0055 16.1 24.7 0.09 12.1 15.2 2.4 1 1 1 2 2 2 2 Growth-arrest specific micro-tubule binding ATG16 PF08614.11 EMD61972.1 - 0.0078 16.5 28.0 0.06 13.6 10.2 2.2 1 1 1 2 2 2 1 Autophagy protein 16 (ATG16) Fib_alpha PF08702.10 EMD61972.1 - 0.0084 16.3 13.2 0.14 12.3 3.3 2.2 2 0 0 2 2 2 2 Fibrinogen alpha/beta chain family Taxilin PF09728.9 EMD61972.1 - 0.0086 15.3 22.3 0.19 10.8 8.7 2.1 2 0 0 2 2 2 2 Myosin-like coiled-coil protein bZIP_1 PF00170.21 EMD61972.1 - 0.0089 16.1 24.8 0.21 11.7 5.2 4.6 3 1 1 4 4 4 1 bZIP transcription factor Jnk-SapK_ap_N PF09744.9 EMD61972.1 - 0.0092 16.2 28.2 0.014 15.6 15.1 2.1 1 1 1 2 2 2 1 JNK_SAPK-associated protein-1 Myosin_tail_1 PF01576.19 EMD61972.1 - 0.012 13.4 24.8 0.015 13.1 24.8 1.1 1 0 0 1 1 1 0 Myosin tail TMF_DNA_bd PF12329.8 EMD61972.1 - 0.013 15.5 29.4 0.12 12.4 11.0 3.3 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding Lebercilin PF15619.6 EMD61972.1 - 0.016 14.9 27.6 0.64 9.6 14.0 2.4 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease TolA_bind_tri PF16331.5 EMD61972.1 - 0.016 15.3 1.5 0.016 15.3 1.5 3.8 2 1 2 4 4 4 0 TolA binding protein trimerisation BRE1 PF08647.11 EMD61972.1 - 0.016 15.2 27.6 0.083 13.0 13.5 2.9 1 1 2 3 3 3 0 BRE1 E3 ubiquitin ligase Laminin_II PF06009.12 EMD61972.1 - 0.018 15.1 16.9 0.036 14.1 3.4 2.2 1 1 1 2 2 2 0 Laminin Domain II Fez1 PF06818.15 EMD61972.1 - 0.024 15.1 23.9 0.032 14.7 22.7 1.6 1 1 0 1 1 1 0 Fez1 Spc7 PF08317.11 EMD61972.1 - 0.029 13.2 29.0 0.19 10.6 10.1 2.0 1 1 1 2 2 2 0 Spc7 kinetochore protein VGPC1_C PF16799.5 EMD61972.1 - 0.029 14.3 0.9 0.029 14.3 0.9 3.5 2 2 1 3 3 3 0 C-terminal membrane-localisation domain of ion-channel, VCN1 Spectrin PF00435.21 EMD61972.1 - 0.034 14.6 22.7 0.13 12.7 8.7 2.4 1 1 0 2 2 2 0 Spectrin repeat DUF4200 PF13863.6 EMD61972.1 - 0.036 14.4 29.9 0.27 11.6 9.4 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4200) FlaC_arch PF05377.11 EMD61972.1 - 0.055 13.9 19.9 0.13 12.7 3.8 4.1 3 1 1 4 4 4 0 Flagella accessory protein C (FlaC) TPR_MLP1_2 PF07926.12 EMD61972.1 - 0.085 12.9 32.1 1.1 9.3 19.3 3.2 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein ERM PF00769.19 EMD61972.1 - 0.095 12.5 31.4 0.18 11.6 12.0 2.0 1 1 1 2 2 2 0 Ezrin/radixin/moesin family ZapB PF06005.12 EMD61972.1 - 0.098 13.1 29.4 1.2 9.7 11.3 3.4 1 1 1 2 2 2 0 Cell division protein ZapB BLOC1_2 PF10046.9 EMD61972.1 - 0.11 12.9 19.2 2.3 8.6 5.1 3.3 1 1 3 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF812 PF05667.11 EMD61972.1 - 0.11 11.3 27.2 0.31 9.9 27.2 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF812) PspA_IM30 PF04012.12 EMD61972.1 - 0.13 11.8 25.9 1.5 8.4 8.6 2.5 1 1 1 2 2 2 0 PspA/IM30 family UPF0242 PF06785.11 EMD61972.1 - 0.13 12.3 27.1 0.2 11.7 11.2 2.0 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Hemagglutinin PF00509.18 EMD61972.1 - 0.14 10.6 9.8 0.29 9.5 1.7 2.0 1 1 1 2 2 2 0 Haemagglutinin CLZ PF16526.5 EMD61972.1 - 0.14 12.6 21.4 0.99 9.8 1.4 4.2 1 1 3 4 4 4 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF4407 PF14362.6 EMD61972.1 - 0.15 11.4 21.1 0.35 10.2 21.1 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) LPP PF04728.13 EMD61972.1 - 0.15 12.5 10.5 6.5 7.2 0.2 4.3 3 1 1 4 4 4 0 Lipoprotein leucine-zipper SlyX PF04102.12 EMD61972.1 - 0.15 12.7 17.7 1 10.0 2.7 3.1 1 1 1 3 3 2 0 SlyX EzrA PF06160.12 EMD61972.1 - 0.18 10.0 20.5 0.21 9.7 6.2 2.2 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA Atg14 PF10186.9 EMD61972.1 - 0.2 10.7 23.4 0.14 11.2 7.0 2.0 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Filament PF00038.21 EMD61972.1 - 0.22 11.1 24.6 0.85 9.1 9.3 2.0 1 1 1 2 2 2 0 Intermediate filament protein DUF724 PF05266.14 EMD61972.1 - 0.23 11.2 24.1 0.12 12.1 8.3 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF724) APG6_N PF17675.1 EMD61972.1 - 0.25 11.9 33.8 0.78 10.3 11.3 2.4 1 1 1 2 2 2 0 Apg6 coiled-coil region Fmp27_WPPW PF10359.9 EMD61972.1 - 0.26 10.1 22.3 0.68 8.7 7.5 2.0 1 1 1 2 2 2 0 RNA pol II promoter Fmp27 protein domain STAT_alpha PF01017.20 EMD61972.1 - 0.28 11.0 14.9 0.93 9.4 1.9 2.3 1 1 1 2 2 2 0 STAT protein, all-alpha domain MCC-bdg_PDZ PF10506.9 EMD61972.1 - 0.39 10.8 12.0 0.071 13.1 3.7 3.2 2 2 0 2 2 2 0 PDZ domain of MCC-2 bdg protein for Usher syndrome YabA PF06156.13 EMD61972.1 - 0.41 11.3 17.3 0.37 11.5 5.5 2.5 1 1 1 2 2 2 0 Initiation control protein YabA Cep57_CLD_2 PF14197.6 EMD61972.1 - 0.47 10.6 23.5 0.24 11.5 2.0 4.1 2 2 1 4 4 4 0 Centrosome localisation domain of PPC89 KASH_CCD PF14662.6 EMD61972.1 - 0.48 10.2 27.3 1.6 8.5 9.6 2.2 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH DUF3584 PF12128.8 EMD61972.1 - 0.5 7.8 22.8 0.74 7.3 22.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) HMMR_C PF15908.5 EMD61972.1 - 0.58 10.4 15.0 0.83 9.9 2.8 2.9 1 1 1 3 3 3 0 Hyaluronan mediated motility receptor C-terminal Mod_r PF07200.13 EMD61972.1 - 0.67 10.0 22.8 46 4.1 22.8 2.3 1 1 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein XLF PF09302.11 EMD61972.1 - 0.7 10.0 9.0 1.6 8.9 0.9 2.4 2 1 0 2 2 2 0 XLF-Cernunnos, XRcc4-like factor, NHEJ component KELK PF15796.5 EMD61972.1 - 0.72 10.3 30.6 1.8 9.1 3.3 3.2 2 1 1 3 3 3 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase WXG100 PF06013.12 EMD61972.1 - 0.74 10.1 11.4 17 5.7 0.1 3.4 2 1 1 3 3 3 0 Proteins of 100 residues with WXG Nup88 PF10168.9 EMD61972.1 - 0.82 7.4 21.8 1.1 7.0 5.6 2.0 1 1 1 2 2 2 0 Nuclear pore component MS_channel PF00924.18 EMD61972.1 - 0.9 9.0 2.7 1.3 8.6 2.3 1.6 1 1 0 1 1 1 0 Mechanosensitive ion channel AAA_13 PF13166.6 EMD61972.1 - 0.95 8.0 21.5 16 4.0 21.5 2.1 1 1 0 1 1 1 0 AAA domain CENP-H PF05837.12 EMD61972.1 - 1 9.8 21.5 3.8 8.0 15.5 2.5 1 1 1 2 2 2 0 Centromere protein H (CENP-H) IFT46_B_C PF12317.8 EMD61972.1 - 1 9.1 11.0 0.1 12.4 4.3 2.0 1 1 1 2 2 2 0 Intraflagellar transport complex B protein 46 C terminal CtIP_N PF10482.9 EMD61972.1 - 1 9.4 19.1 0.11 12.5 5.1 2.7 2 1 0 2 2 2 0 Tumour-suppressor protein CtIP N-terminal domain Fungal_TACC PF12709.7 EMD61972.1 - 1.1 9.8 25.5 0.96 9.9 4.8 3.9 2 2 2 4 4 4 0 Fungal Transforming acidic coiled-coil (TACC) proteins Ax_dynein_light PF10211.9 EMD61972.1 - 1.1 9.2 28.3 1.8 8.5 2.3 3.3 1 1 1 3 3 3 0 Axonemal dynein light chain KxDL PF10241.9 EMD61972.1 - 1.1 9.6 15.4 0.42 10.9 0.9 3.2 1 1 2 3 3 3 0 Uncharacterized conserved protein Cortex-I_coil PF09304.10 EMD61972.1 - 1.2 9.4 20.7 1.9 8.8 4.0 3.1 1 1 2 3 3 3 0 Cortexillin I, coiled coil Prefoldin_2 PF01920.20 EMD61972.1 - 1.2 9.1 30.9 4.4 7.3 7.5 4.0 1 1 3 4 4 4 0 Prefoldin subunit Cep57_MT_bd PF06657.13 EMD61972.1 - 1.3 9.5 19.5 7.8 7.0 6.2 3.4 2 2 1 3 3 3 0 Centrosome microtubule-binding domain of Cep57 DUF5595 PF18077.1 EMD61972.1 - 1.3 9.1 15.9 0.22 11.7 2.6 3.4 3 1 0 3 3 3 0 Domain of unknown function (DUF5595) HOOK PF05622.12 EMD61972.1 - 1.4 7.0 24.2 2.1 6.4 24.2 1.3 1 1 0 1 1 1 0 HOOK protein FUSC PF04632.12 EMD61972.1 - 1.4 7.4 6.6 1.6 7.2 6.6 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Sec20 PF03908.13 EMD61972.1 - 1.4 8.9 8.4 0.69 9.9 1.1 2.4 2 1 0 2 2 2 0 Sec20 DUF948 PF06103.11 EMD61972.1 - 1.5 9.1 11.7 5.7 7.3 3.1 2.9 1 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) Swi5 PF07061.11 EMD61972.1 - 2 8.6 21.9 3.5 7.8 0.7 3.9 1 1 2 3 3 3 0 Swi5 OmpH PF03938.14 EMD61972.1 - 2 8.7 27.4 1.8e+04 -4.3 27.4 2.3 1 1 0 1 1 0 0 Outer membrane protein (OmpH-like) Lectin_N PF03954.14 EMD61972.1 - 2 8.1 13.3 15 5.3 2.8 2.5 1 1 1 2 2 2 0 Hepatic lectin, N-terminal domain YjcZ PF13990.6 EMD61972.1 - 2.1 7.7 8.9 0.35 10.2 1.9 1.9 1 1 1 2 2 2 0 YjcZ-like protein DUF1843 PF08898.10 EMD61972.1 - 2.1 8.9 7.9 1.7 9.2 3.3 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF1843) Syntaxin_2 PF14523.6 EMD61972.1 - 2.2 8.7 15.2 0.89 10.0 8.7 2.3 1 1 1 2 2 2 0 Syntaxin-like protein DUF641 PF04859.12 EMD61972.1 - 2.5 8.4 20.1 0.99 9.7 6.9 2.6 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) DUF4795 PF16043.5 EMD61972.1 - 2.7 7.6 21.8 41 3.7 21.8 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) DUF2730 PF10805.8 EMD61972.1 - 2.8 8.1 11.8 0.5 10.5 2.5 3.0 2 2 0 2 2 2 0 Protein of unknown function (DUF2730) XhlA PF10779.9 EMD61972.1 - 3.2 8.0 20.8 2.5 8.4 1.7 3.9 1 1 3 4 4 4 0 Haemolysin XhlA Prefoldin PF02996.17 EMD61972.1 - 3.4 7.6 24.0 3.1 7.7 2.0 3.7 2 1 2 4 4 4 0 Prefoldin subunit JIP_LZII PF16471.5 EMD61972.1 - 3.5 7.9 25.7 0.23 11.6 2.8 4.1 3 1 1 4 4 4 0 JNK-interacting protein leucine zipper II PIN_9 PF18477.1 EMD61972.1 - 3.5 8.0 7.9 1.2 9.4 1.5 2.3 1 1 1 2 2 2 0 PIN like domain IFP_35_N PF07334.13 EMD61972.1 - 3.5 7.8 15.7 7 6.8 0.3 3.5 2 1 1 3 3 3 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus ARGLU PF15346.6 EMD61972.1 - 3.5 7.5 32.2 3.3 7.6 12.3 2.1 1 1 1 2 2 2 0 Arginine and glutamate-rich 1 DUF4201 PF13870.6 EMD61972.1 - 3.6 7.3 22.8 2.9 7.6 8.3 2.2 1 1 0 2 2 2 0 Domain of unknown function (DUF4201) V_ATPase_I PF01496.19 EMD61972.1 - 3.6 5.4 20.5 1.3 6.8 6.6 2.0 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family SOGA PF11365.8 EMD61972.1 - 4.5 8.5 19.5 1.9 9.7 10.9 2.8 1 1 2 3 3 3 0 Protein SOGA Syntaxin-6_N PF09177.11 EMD61972.1 - 4.6 7.8 18.3 3.1 8.4 5.9 2.7 1 1 1 2 2 2 0 Syntaxin 6, N-terminal CASP_C PF08172.12 EMD61972.1 - 4.7 6.5 14.8 10 5.4 12.9 2.2 1 1 1 2 2 2 0 CASP C terminal TMCO5 PF14992.6 EMD61972.1 - 4.9 6.6 23.1 2.1 7.9 15.1 2.4 1 1 1 2 2 2 0 TMCO5 family HemX PF04375.14 EMD61972.1 - 5 6.3 22.6 2.2 7.5 7.2 2.2 1 1 1 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase FtsX_ECD PF18075.1 EMD61972.1 - 5 7.8 10.9 0.54 10.9 3.3 2.6 1 1 1 2 2 2 0 FtsX extracellular domain DUF4472 PF14739.6 EMD61972.1 - 5.2 7.9 23.0 16 6.3 9.8 2.5 1 1 2 3 3 3 0 Domain of unknown function (DUF4472) DHR10 PF18595.1 EMD61972.1 - 5.7 7.0 31.5 5.9 7.0 10.9 2.9 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain Sec8_exocyst PF04048.14 EMD61972.1 - 6 6.7 12.3 0.93 9.4 1.2 2.5 2 1 0 2 2 2 0 Sec8 exocyst complex component specific domain Troponin PF00992.20 EMD61972.1 - 6.4 7.1 26.9 0.1 12.9 7.2 2.5 1 1 0 2 2 2 0 Troponin Nup54 PF13874.6 EMD61972.1 - 7.5 6.7 19.9 9.8 6.3 15.9 2.2 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 Occludin_ELL PF07303.13 EMD61972.1 - 7.7 7.3 17.6 21 5.9 6.7 2.9 1 1 0 2 2 2 0 Occludin homology domain HAUS-augmin3 PF14932.6 EMD61972.1 - 8.2 5.9 24.6 2.4 7.7 8.6 2.2 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 3 TMPIT PF07851.13 EMD61972.1 - 9 5.4 20.8 3.4 6.8 7.2 2.0 1 1 1 2 2 2 0 TMPIT-like protein Striatin PF08232.12 EMD61972.1 - 9.9 6.7 22.0 44 4.6 22.0 1.9 1 1 0 1 1 1 0 Striatin family Nop25 PF09805.9 EMD61973.1 - 9.1e-39 133.1 17.2 9.1e-39 133.1 17.2 3.0 2 1 0 2 2 2 1 Nucleolar protein 12 (25kDa) Prenyltrans PF00432.21 EMD61974.1 - 2.2e-28 97.7 8.2 9.4e-07 28.5 0.0 5.8 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_C PF13243.6 EMD61974.1 - 0.00046 19.4 0.0 0.0035 16.5 0.0 2.4 2 1 0 2 2 2 1 Squalene-hopene cyclase C-terminal domain TED_complement PF07678.14 EMD61974.1 - 0.024 13.7 0.1 1.2 8.1 0.0 3.0 3 1 0 3 3 3 0 A-macroglobulin TED domain SQHop_cyclase_N PF13249.6 EMD61974.1 - 0.13 11.3 0.0 11 5.0 0.0 2.5 3 0 0 3 3 3 0 Squalene-hopene cyclase N-terminal domain RhoGAP PF00620.27 EMD61975.1 - 1.2e-17 64.2 0.1 2.9e-17 62.9 0.0 1.7 2 0 0 2 2 2 1 RhoGAP domain DEP PF00610.21 EMD61975.1 - 1.9e-12 47.1 0.0 3.7e-12 46.1 0.0 1.5 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) FCH PF00611.23 EMD61975.1 - 1.2e-09 38.3 0.1 1.2e-08 35.1 0.0 2.4 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain Syja_N PF02383.18 EMD61977.1 - 5e-77 259.3 0.0 7.2e-77 258.8 0.0 1.2 1 0 0 1 1 1 1 SacI homology domain Exo_endo_phos PF03372.23 EMD61977.1 - 6.6e-09 35.6 0.1 1.3e-08 34.7 0.1 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family YkyB PF14177.6 EMD61977.1 - 0.19 12.0 0.1 0.49 10.7 0.0 1.6 2 0 0 2 2 2 0 YkyB-like protein WW PF00397.26 EMD61978.1 - 8.9e-12 44.9 0.6 2.5e-11 43.5 0.6 1.9 1 0 0 1 1 1 1 WW domain PhoD PF09423.10 EMD61978.1 - 0.018 14.1 0.0 0.036 13.1 0.0 1.5 1 0 0 1 1 1 0 PhoD-like phosphatase DUF1640 PF07798.11 EMD61979.1 - 2.8e-57 193.6 12.6 3.6e-57 193.2 12.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) Integrase_Zn PF02022.19 EMD61979.1 - 0.07 13.1 0.1 0.17 11.8 0.1 1.6 1 0 0 1 1 1 0 Integrase Zinc binding domain GreA_GreB_N PF03449.15 EMD61979.1 - 0.32 11.2 8.6 1.5 9.0 8.6 2.2 1 0 0 1 1 1 0 Transcription elongation factor, N-terminal 14-3-3 PF00244.20 EMD61980.1 - 4.1e-103 343.7 1.5 5e-103 343.4 1.5 1.1 1 0 0 1 1 1 1 14-3-3 protein zf-CSL PF05207.13 EMD61981.1 - 3.1e-15 55.7 0.5 5e-15 55.0 0.5 1.4 1 0 0 1 1 1 1 CSL zinc finger DnaJ PF00226.31 EMD61981.1 - 8.8e-08 32.2 2.6 2e-07 31.0 2.6 1.7 1 1 0 1 1 1 1 DnaJ domain HNH_2 PF13391.6 EMD61982.1 - 4.7e-09 36.3 0.2 1.2e-08 35.0 0.2 1.7 1 0 0 1 1 1 1 HNH endonuclease RRM_1 PF00076.22 EMD61983.1 - 8.2e-10 38.4 0.0 2.4e-09 36.9 0.0 1.8 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EMD61983.1 - 0.00021 20.9 0.0 0.00029 20.4 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Calcipressin PF04847.12 EMD61983.1 - 0.004 16.9 0.6 0.0084 15.9 0.0 1.7 2 0 0 2 2 2 1 Calcipressin DUF4523 PF15023.6 EMD61983.1 - 0.019 14.8 0.0 0.026 14.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4523) RRM_occluded PF16842.5 EMD61983.1 - 0.035 14.0 0.0 0.061 13.2 0.0 1.4 1 0 0 1 1 1 0 Occluded RNA-recognition motif Limkain-b1 PF11608.8 EMD61983.1 - 0.054 13.6 0.0 0.16 12.1 0.0 1.7 1 1 0 1 1 1 0 Limkain b1 Pkinase PF00069.25 EMD61984.1 - 5.1e-56 189.9 0.0 6.1e-56 189.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD61984.1 - 6.3e-34 117.4 0.0 8.1e-34 117.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase CPSase_L_D2 PF02786.17 EMD61985.1 - 7e-81 270.7 0.1 1.1e-80 270.1 0.1 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain PYC_OADA PF02436.18 EMD61985.1 - 3.1e-69 232.7 0.0 5.1e-69 232.0 0.0 1.4 1 0 0 1 1 1 1 Conserved carboxylase domain Biotin_carb_N PF00289.22 EMD61985.1 - 3e-39 134.0 0.0 6.2e-39 132.9 0.0 1.6 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain HMGL-like PF00682.19 EMD61985.1 - 7.2e-30 104.4 0.0 1.5e-29 103.4 0.0 1.5 1 0 0 1 1 1 1 HMGL-like Biotin_carb_C PF02785.19 EMD61985.1 - 7.5e-30 103.2 0.0 1.9e-29 101.9 0.0 1.8 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 EMD61985.1 - 1e-19 70.1 1.2 2.6e-19 68.8 1.2 1.7 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 EMD61985.1 - 5.3e-11 42.2 0.7 1.5e-05 24.7 0.1 2.6 1 1 1 2 2 2 2 Biotin-lipoyl like Dala_Dala_lig_C PF07478.13 EMD61985.1 - 8.9e-09 35.2 0.0 1.8e-08 34.2 0.0 1.4 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 EMD61985.1 - 2.8e-06 27.0 0.0 5.7e-06 26.0 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.14 EMD61985.1 - 4.2e-05 23.6 0.0 0.00012 22.2 0.0 1.8 2 0 0 2 2 2 1 ATP-grasp domain RimK PF08443.11 EMD61985.1 - 0.00037 20.2 0.0 0.00086 18.9 0.0 1.6 1 1 0 1 1 1 1 RimK-like ATP-grasp domain HlyD_3 PF13437.6 EMD61985.1 - 0.0016 19.2 0.2 0.44 11.3 0.0 3.5 3 0 0 3 3 3 1 HlyD family secretion protein HlyD_D23 PF16576.5 EMD61985.1 - 0.0016 17.7 0.0 0.54 9.4 0.0 2.3 1 1 1 2 2 2 2 Barrel-sandwich domain of CusB or HlyD membrane-fusion ATPgrasp_ST PF14397.6 EMD61985.1 - 0.067 12.4 0.0 0.22 10.7 0.0 1.8 2 0 0 2 2 2 0 Sugar-transfer associated ATP-grasp ATPgrasp_Ter PF15632.6 EMD61985.1 - 0.1 12.3 0.1 0.3 10.8 0.1 1.7 1 0 0 1 1 1 0 ATP-grasp in the biosynthetic pathway with Ter operon Orf78 PF06024.12 EMD61986.1 - 0.071 13.4 1.5 0.11 12.8 1.2 1.5 1 1 0 1 1 1 0 Orf78 (ac78) tRNA-synt_1d PF00750.19 EMD61987.1 - 5.2e-38 130.9 1.6 1.3e-18 67.1 0.1 2.4 1 1 1 2 2 2 2 tRNA synthetases class I (R) DALR_1 PF05746.15 EMD61987.1 - 6.3e-13 48.9 0.6 4.3e-12 46.3 0.1 2.2 2 0 0 2 2 2 1 DALR anticodon binding domain DUF2935 PF11155.8 EMD61988.1 - 0.094 13.0 3.5 1.1 9.5 1.9 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF2935) DUF755 PF05501.11 EMD61988.1 - 0.17 12.2 0.1 0.17 12.2 0.1 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF755) YabA PF06156.13 EMD61988.1 - 0.31 11.7 7.8 3.2 8.4 7.7 2.4 1 1 1 2 2 2 0 Initiation control protein YabA M20_dimer PF07687.14 EMD61989.1 - 1.5e-19 69.9 0.1 2.6e-19 69.2 0.1 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M20 PF01546.28 EMD61989.1 - 2.8e-17 63.1 0.2 7.2e-14 52.0 0.1 2.2 2 0 0 2 2 2 2 Peptidase family M20/M25/M40 Peptidase_M28 PF04389.17 EMD61989.1 - 0.0095 15.6 0.0 0.022 14.5 0.0 1.5 2 0 0 2 2 2 1 Peptidase family M28 UBA_4 PF14555.6 EMD61989.1 - 0.11 12.4 1.9 0.35 10.7 0.1 2.4 2 1 1 3 3 3 0 UBA-like domain M16C_assoc PF08367.11 EMD61990.1 - 1.7e-85 286.2 0.7 2.5e-85 285.6 0.7 1.3 1 0 0 1 1 1 1 Peptidase M16C associated Peptidase_M16_C PF05193.21 EMD61990.1 - 5.6e-29 101.5 0.0 3.4e-23 82.6 0.0 3.0 3 0 0 3 3 3 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EMD61990.1 - 1.2e-07 31.9 0.1 6.8e-06 26.1 0.0 3.2 3 0 0 3 3 3 1 Insulinase (Peptidase family M16) Effector_1 PF04518.12 EMD61990.1 - 0.099 11.7 2.6 1.2 8.2 0.1 2.2 2 0 0 2 2 2 0 Effector from type III secretion system Taxilin PF09728.9 EMD61992.1 - 3.3e-42 144.7 34.3 3.3e-42 144.7 34.3 1.4 2 0 0 2 2 2 1 Myosin-like coiled-coil protein TFIIA PF03153.13 EMD61992.1 - 0.0053 16.8 23.2 0.0072 16.4 23.2 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit SidC_N PF18219.1 EMD61992.1 - 0.022 13.7 10.2 0.16 10.9 1.5 2.1 1 1 1 2 2 2 0 SidC N-terminal domain Caldesmon PF02029.15 EMD61992.1 - 0.052 12.3 27.4 0.065 12.0 27.4 1.1 1 0 0 1 1 1 0 Caldesmon RNA_pol_3_Rpc31 PF11705.8 EMD61992.1 - 0.37 11.0 23.7 0.58 10.4 23.7 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 PRIMA1 PF16101.5 EMD61992.1 - 1.6 8.8 4.5 3.4 7.7 4.5 1.5 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 DUF3450 PF11932.8 EMD61992.1 - 3.6 6.8 24.5 1.2 8.3 9.6 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) FAM76 PF16046.5 EMD61992.1 - 7.1 5.9 25.9 2.7 7.3 23.5 1.4 1 1 0 1 1 1 0 FAM76 protein DUF4239 PF14023.6 EMD61992.1 - 9.7 5.8 8.9 15 5.3 8.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4239) peroxidase PF00141.23 EMD61993.1 - 1.7e-19 70.4 0.1 2.9e-19 69.7 0.1 1.3 1 0 0 1 1 1 1 Peroxidase NMO PF03060.15 EMD61994.1 - 1.1e-52 179.5 2.0 1.5e-52 179.0 2.0 1.2 1 0 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.25 EMD61994.1 - 2.9e-09 36.4 3.5 1e-08 34.6 3.5 2.0 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.18 EMD61994.1 - 6.3e-05 22.2 2.2 0.0001 21.5 2.2 1.3 1 0 0 1 1 1 1 FMN-dependent dehydrogenase FATC PF02260.20 EMD61994.1 - 0.0061 16.3 0.2 0.029 14.2 0.0 2.0 2 0 0 2 2 2 1 FATC domain PEP_hydrolase PF09370.10 EMD61994.1 - 0.043 13.0 0.0 0.08 12.1 0.0 1.4 1 0 0 1 1 1 0 Phosphoenolpyruvate hydrolase-like Pkinase PF00069.25 EMD61995.1 - 1.5e-66 224.5 0.0 2.2e-66 223.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD61995.1 - 1.6e-40 139.0 0.0 2.4e-40 138.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMD61995.1 - 1.2e-07 31.3 0.0 3.1e-07 30.0 0.0 1.6 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 EMD61995.1 - 6.4e-05 22.1 0.1 6.4e-05 22.1 0.1 2.1 2 0 0 2 2 2 1 Haspin like kinase domain APH PF01636.23 EMD61995.1 - 0.0046 16.9 8.4 0.07 13.0 0.3 3.2 2 1 1 3 3 3 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 EMD61995.1 - 0.024 13.7 0.0 0.036 13.1 0.0 1.1 1 0 0 1 1 1 0 Seadornavirus VP7 Kdo PF06293.14 EMD61995.1 - 0.029 13.7 0.3 0.16 11.3 0.0 2.0 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 EMD61995.1 - 0.25 10.9 2.5 0.33 10.5 0.0 2.3 2 1 1 3 3 3 0 RIO1 family AA_permease PF00324.21 EMD61996.1 - 7.8e-144 479.8 33.3 8.9e-144 479.6 33.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EMD61996.1 - 5.9e-38 130.8 34.5 7.3e-38 130.5 34.5 1.0 1 0 0 1 1 1 1 Amino acid permease OppC_N PF12911.7 EMD61996.1 - 0.49 10.4 3.6 39 4.3 0.0 4.4 4 0 0 4 4 4 0 N-terminal TM domain of oligopeptide transport permease C Aldo_ket_red PF00248.21 EMD61997.1 - 3.5e-42 144.6 0.0 1.4e-31 109.8 0.1 2.0 1 1 1 2 2 2 2 Aldo/keto reductase family P3A PF08727.11 EMD61997.1 - 0.037 13.4 1.0 0.13 11.7 1.0 1.8 1 1 0 1 1 1 0 Poliovirus 3A protein like FKBP_C PF00254.28 EMD61998.1 - 4.2e-28 97.5 0.0 5e-28 97.3 0.0 1.0 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase CHCH PF06747.13 EMD61999.1 - 2.5e-05 24.3 2.5 4.6e-05 23.4 2.3 1.6 1 1 0 1 1 1 1 CHCH domain MTCP1 PF08991.10 EMD61999.1 - 0.004 17.3 2.7 0.0057 16.9 2.7 1.2 1 0 0 1 1 1 1 Mature-T-Cell Proliferation I type zf-C3HC4_4 PF15227.6 EMD62000.1 - 7.6e-06 26.0 12.2 7.6e-06 26.0 12.2 2.3 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.6 EMD62000.1 - 3.1e-05 23.7 18.6 0.00025 20.8 11.8 2.4 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMD62000.1 - 4.1e-05 23.3 12.0 4.1e-05 23.3 12.0 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EMD62000.1 - 5.9e-05 23.3 18.1 0.00025 21.3 11.7 2.3 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.6 EMD62000.1 - 7.3e-05 22.5 9.5 7.3e-05 22.5 9.5 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EMD62000.1 - 0.0012 18.8 9.7 0.0012 18.8 9.7 2.1 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 EMD62000.1 - 0.004 17.1 11.7 0.004 17.1 11.7 2.1 2 0 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EMD62000.1 - 0.031 14.2 10.0 0.2 11.5 8.5 2.3 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 EMD62000.1 - 0.89 9.6 8.1 0.19 11.8 2.3 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_10 PF16685.5 EMD62000.1 - 0.99 9.6 8.0 1.9 8.7 8.0 1.4 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-rbx1 PF12678.7 EMD62000.1 - 7.8 6.9 13.9 1.9 8.9 9.2 2.2 2 0 0 2 2 2 0 RING-H2 zinc finger domain DUF1406 PF07190.11 EMD62001.1 - 0.085 12.8 0.1 0.11 12.4 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1406) ETC_C1_NDUFA5 PF04716.14 EMD62003.1 - 0.1 12.4 0.0 0.24 11.2 0.0 1.6 1 0 0 1 1 1 0 ETC complex I subunit conserved region bZIP_1 PF00170.21 EMD62005.1 - 0.058 13.5 1.7 0.089 12.9 1.7 1.3 1 0 0 1 1 1 0 bZIP transcription factor ArfGap PF01412.18 EMD62006.1 - 1.1e-36 125.4 0.1 1.1e-36 125.4 0.1 2.8 3 1 0 3 3 3 1 Putative GTPase activating protein for Arf UBA PF00627.31 EMD62006.1 - 0.019 14.9 0.0 0.059 13.3 0.0 1.9 1 0 0 1 1 1 0 UBA/TS-N domain DnaJ PF00226.31 EMD62007.1 - 4e-18 65.3 2.5 6.6e-18 64.6 2.5 1.3 1 0 0 1 1 1 1 DnaJ domain baeRF_family12 PF18856.1 EMD62008.1 - 0.56 10.8 1.4 0.83 10.2 0.1 1.8 1 1 1 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 12 PRA1 PF03208.19 EMD62010.1 - 3.7e-38 130.4 0.6 5.3e-38 129.9 0.6 1.2 1 0 0 1 1 1 1 PRA1 family protein DUF2207 PF09972.9 EMD62010.1 - 0.0082 15.0 0.4 0.009 14.8 0.4 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) DnaJ PF00226.31 EMD62011.1 - 5.6e-11 42.4 0.3 5.5e-09 36.0 0.1 2.5 2 0 0 2 2 2 2 DnaJ domain LapA_dom PF06305.11 EMD62011.1 - 6.9 6.6 5.1 25 4.8 0.1 2.8 3 0 0 3 3 3 0 Lipopolysaccharide assembly protein A domain Mucin PF01456.17 EMD62012.1 - 0.029 14.3 16.6 0.08 12.9 16.6 1.8 1 0 0 1 1 1 0 Mucin-like glycoprotein Fcf1 PF04900.12 EMD62013.1 - 6.8e-36 122.6 0.1 1.2e-35 121.8 0.1 1.4 1 0 0 1 1 1 1 Fcf1 PIN_9 PF18477.1 EMD62013.1 - 1.6e-14 54.2 1.6 1.3e-13 51.3 0.1 2.0 2 0 0 2 2 2 1 PIN like domain GCV_T PF01571.21 EMD62013.1 - 0.17 11.2 0.0 0.25 10.7 0.0 1.2 1 0 0 1 1 1 0 Aminomethyltransferase folate-binding domain HlyIII PF03006.20 EMD62014.1 - 5.4e-62 209.4 22.3 6.9e-62 209.1 22.3 1.1 1 0 0 1 1 1 1 Haemolysin-III related Colicin_V PF02674.16 EMD62014.1 - 0.04 13.9 1.6 0.1 12.6 1.6 1.6 1 0 0 1 1 1 0 Colicin V production protein IF-2B PF01008.17 EMD62015.1 - 1.7e-71 240.7 0.7 2e-71 240.5 0.7 1.0 1 0 0 1 1 1 1 Initiation factor 2 subunit family EF-hand_4 PF12763.7 EMD62016.1 - 2.8e-27 94.7 0.0 2e-13 50.2 0.0 2.4 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand WH2 PF02205.20 EMD62016.1 - 9.2e-08 31.7 0.4 9.2e-08 31.7 0.4 3.4 4 0 0 4 4 4 1 WH2 motif DUF1720 PF08226.11 EMD62016.1 - 3.4e-07 30.6 62.4 2.9e-05 24.4 22.3 7.4 5 2 2 7 7 7 2 Domain of unknown function (DUF1720) EF-hand_7 PF13499.6 EMD62016.1 - 5.2e-05 23.6 0.0 0.084 13.3 0.0 2.9 2 0 0 2 2 2 2 EF-hand domain pair E3_binding PF02817.17 EMD62016.1 - 0.012 15.9 0.2 0.26 11.7 0.1 2.6 2 0 0 2 2 2 0 e3 binding domain HAGH_C PF16123.5 EMD62016.1 - 0.066 13.7 0.3 0.066 13.7 0.3 2.7 3 0 0 3 3 3 0 Hydroxyacylglutathione hydrolase C-terminus 2OG-FeII_Oxy_3 PF13640.6 EMD62017.1 - 9.5e-12 45.7 0.1 1.8e-11 44.7 0.1 1.5 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Cyclin PF08613.11 EMD62018.1 - 2.3e-39 135.4 9.3 5e-24 85.5 0.6 3.2 3 1 0 3 3 3 2 Cyclin Proteasome PF00227.26 EMD62019.1 - 1.5e-48 164.8 0.1 1.8e-48 164.6 0.1 1.0 1 0 0 1 1 1 1 Proteasome subunit Hydrolase_4 PF12146.8 EMD62020.1 - 3.2e-14 52.8 0.0 9.5e-11 41.4 0.0 2.1 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EMD62020.1 - 1.3e-10 41.4 0.0 4.4e-08 33.1 0.0 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold AXE1 PF05448.12 EMD62020.1 - 1.4e-06 27.2 0.4 0.036 12.7 0.2 2.6 2 1 1 3 3 3 2 Acetyl xylan esterase (AXE1) Abhydrolase_6 PF12697.7 EMD62020.1 - 3.9e-05 24.4 0.0 9.3e-05 23.1 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 EMD62020.1 - 5.2e-05 22.8 0.0 0.00018 21.0 0.0 1.8 1 1 0 1 1 1 1 Prolyl oligopeptidase family BAAT_C PF08840.11 EMD62020.1 - 9.8e-05 22.4 0.0 0.0062 16.5 0.0 2.3 1 1 1 2 2 2 1 BAAT / Acyl-CoA thioester hydrolase C terminal FSH1 PF03959.13 EMD62020.1 - 9.9e-05 22.1 0.0 0.00031 20.5 0.0 1.7 2 0 0 2 2 2 1 Serine hydrolase (FSH1) LIDHydrolase PF10230.9 EMD62020.1 - 0.0002 21.0 0.0 0.0031 17.1 0.0 2.0 2 0 0 2 2 2 1 Lipid-droplet associated hydrolase DLH PF01738.18 EMD62020.1 - 0.00051 19.7 0.0 0.0045 16.6 0.0 2.1 1 1 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_3 PF07859.13 EMD62020.1 - 0.0023 17.8 0.0 0.0033 17.3 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF818 PF05677.12 EMD62020.1 - 0.0052 15.8 0.1 0.0071 15.3 0.1 1.1 1 0 0 1 1 1 1 Chlamydia CHLPS protein (DUF818) Thioesterase PF00975.20 EMD62020.1 - 0.037 14.1 0.0 0.052 13.7 0.0 1.2 1 0 0 1 1 1 0 Thioesterase domain Abhydrolase_2 PF02230.16 EMD62020.1 - 0.039 13.7 0.3 4.7 7.0 0.0 2.4 2 1 0 3 3 3 0 Phospholipase/Carboxylesterase PGAP1 PF07819.13 EMD62020.1 - 0.048 13.4 0.1 0.3 10.8 0.1 2.1 1 1 0 1 1 1 0 PGAP1-like protein PhoPQ_related PF10142.9 EMD62020.1 - 0.14 10.8 0.0 0.18 10.5 0.0 1.1 1 0 0 1 1 1 0 PhoPQ-activated pathogenicity-related protein Peptidase_S15 PF02129.18 EMD62020.1 - 0.17 11.4 0.0 13 5.2 0.0 2.1 2 0 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) Lipase_3 PF01764.25 EMD62020.1 - 0.2 11.5 0.0 0.3 10.9 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) YTH PF04146.15 EMD62021.1 - 8.9e-62 207.9 0.0 1.7e-61 207.0 0.0 1.5 1 0 0 1 1 1 1 YT521-B-like domain RRM_1 PF00076.22 EMD62021.1 - 2.8e-07 30.3 0.0 5.4e-07 29.3 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Glyco_hydro_3 PF00933.21 EMD62022.1 - 3.7e-55 187.5 0.0 5.8e-55 186.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.22 EMD62022.1 - 1e-54 185.6 0.0 3.3e-54 183.9 0.0 1.9 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.6 EMD62022.1 - 4.7e-18 65.1 0.2 1e-17 64.0 0.2 1.6 1 0 0 1 1 1 1 Fibronectin type III-like domain PA14 PF07691.12 EMD62022.1 - 1.7e-05 24.7 0.0 5.6e-05 23.0 0.0 1.8 2 0 0 2 2 2 1 PA14 domain Far-17a_AIG1 PF04750.14 EMD62023.1 - 4.1e-42 143.8 7.5 4.8e-42 143.6 7.5 1.0 1 0 0 1 1 1 1 FAR-17a/AIG1-like protein Prenyltrans PF00432.21 EMD62025.1 - 1.4e-56 187.8 10.3 3.1e-11 42.8 0.1 6.1 6 0 0 6 6 6 6 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_C PF13243.6 EMD62025.1 - 0.0071 15.5 0.2 0.059 12.5 0.1 2.3 1 1 1 2 2 2 1 Squalene-hopene cyclase C-terminal domain SQHop_cyclase_N PF13249.6 EMD62025.1 - 0.0088 15.2 0.0 11 5.0 0.0 3.6 2 1 2 4 4 4 2 Squalene-hopene cyclase N-terminal domain RhoGAP PF00620.27 EMD62027.1 - 2.7e-30 105.2 0.0 2.7e-30 105.2 0.0 1.8 2 0 0 2 2 1 1 RhoGAP domain TFIIA PF03153.13 EMD62027.1 - 0.00068 19.8 17.3 0.00068 19.8 17.3 2.3 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit DDHD PF02862.17 EMD62027.1 - 0.0023 18.1 1.7 0.0023 18.1 1.7 2.6 2 1 0 2 2 1 1 DDHD domain YfhO PF09586.10 EMD62027.1 - 0.14 10.3 4.0 0.18 10.0 4.0 1.1 1 0 0 1 1 1 0 Bacterial membrane protein YfhO CDC45 PF02724.14 EMD62027.1 - 0.16 10.3 6.4 0.25 9.6 6.4 1.3 1 0 0 1 1 1 0 CDC45-like protein Hid1 PF12722.7 EMD62027.1 - 2.4 6.2 11.6 0.02 13.0 2.4 2.1 2 0 0 2 2 2 0 High-temperature-induced dauer-formation protein SpoIIP PF07454.11 EMD62027.1 - 2.5 7.5 17.3 5.4 6.4 17.3 1.5 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Tim54 PF11711.8 EMD62027.1 - 3 6.6 12.6 6.2 5.5 12.6 1.4 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Paf1 PF03985.13 EMD62027.1 - 5.5 5.9 18.6 10 5.0 18.6 1.3 1 0 0 1 1 1 0 Paf1 DUF913 PF06025.12 EMD62027.1 - 7 5.5 9.6 0.092 11.7 2.0 1.7 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) eIF-3_zeta PF05091.12 EMD62027.1 - 8.8 5.2 19.7 19 4.1 19.7 1.4 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) hDGE_amylase PF14701.6 EMD62028.1 - 1.6e-181 604.2 0.0 2.2e-181 603.8 0.0 1.2 1 0 0 1 1 1 1 Glycogen debranching enzyme, glucanotransferase domain GDE_C PF06202.14 EMD62028.1 - 8.4e-118 393.6 0.1 1.6e-117 392.7 0.1 1.5 1 0 0 1 1 1 1 Amylo-alpha-1,6-glucosidase hGDE_central PF14702.6 EMD62028.1 - 1.8e-87 293.2 0.0 3.4e-87 292.3 0.0 1.5 1 0 0 1 1 1 1 Central domain of human glycogen debranching enzyme hGDE_N PF14699.6 EMD62028.1 - 1e-26 92.8 0.1 3.2e-26 91.3 0.1 1.9 1 0 0 1 1 1 1 N-terminal domain from the human glycogen debranching enzyme Alpha-amylase PF00128.24 EMD62028.1 - 4e-05 23.3 0.4 0.00012 21.8 0.1 1.8 2 0 0 2 2 2 1 Alpha amylase, catalytic domain CBP_BcsF PF11120.8 EMD62029.1 - 0.033 14.3 0.2 0.041 14.0 0.2 1.2 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsF DUF818 PF05677.12 EMD62029.1 - 0.079 11.9 0.0 0.081 11.9 0.0 1.0 1 0 0 1 1 1 0 Chlamydia CHLPS protein (DUF818) PRT_C PF08372.10 EMD62034.1 - 0.17 11.7 1.1 0.21 11.3 1.1 1.1 1 0 0 1 1 1 0 Plant phosphoribosyltransferase C-terminal LMBR1 PF04791.16 EMD62034.1 - 0.18 10.7 1.3 0.21 10.5 1.3 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Aldedh PF00171.22 EMD62036.1 - 9.8e-180 598.0 1.2 1.1e-179 597.8 1.2 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 EMD62036.1 - 0.0019 17.3 0.1 0.0082 15.2 0.0 1.8 1 1 0 2 2 2 1 Acyl-CoA reductase (LuxC) Wtap PF17098.5 EMD62036.1 - 0.0029 17.6 0.0 0.0056 16.6 0.0 1.4 1 0 0 1 1 1 1 WTAP/Mum2p family DUF1487 PF07368.11 EMD62036.1 - 0.1 12.0 0.0 0.61 9.5 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1487) Focal_AT PF03623.13 EMD62036.1 - 0.14 12.1 0.0 0.29 11.1 0.0 1.4 1 0 0 1 1 1 0 Focal adhesion targeting region Glyco_transf_20 PF00982.21 EMD62037.1 - 8.7e-157 522.6 0.1 1.4e-156 521.9 0.1 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 EMD62037.1 - 9.7e-47 159.0 0.0 1.7e-46 158.2 0.0 1.4 1 0 0 1 1 1 1 Trehalose-phosphatase Fer2_3 PF13085.6 EMD62040.1 - 6.2e-32 109.9 0.0 1e-31 109.2 0.0 1.4 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer4_17 PF13534.6 EMD62040.1 - 1.1e-08 35.5 6.8 1.1e-08 35.5 6.8 2.1 2 1 0 2 2 2 1 4Fe-4S dicluster domain Fer4_8 PF13183.6 EMD62040.1 - 1.4e-07 31.9 7.8 1.4e-07 31.9 7.8 2.5 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_10 PF13237.6 EMD62040.1 - 1e-06 28.8 3.4 1e-06 28.8 3.4 2.1 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer2 PF00111.27 EMD62040.1 - 0.0033 17.3 2.5 0.012 15.5 0.4 2.4 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Fer4_7 PF12838.7 EMD62040.1 - 0.0036 17.9 4.8 0.0036 17.9 4.8 2.5 2 2 0 2 2 2 1 4Fe-4S dicluster domain Fer4_18 PF13746.6 EMD62040.1 - 0.59 10.3 0.1 0.59 10.3 0.1 2.6 3 0 0 3 3 3 0 4Fe-4S dicluster domain Fer4_9 PF13187.6 EMD62040.1 - 7.1 6.9 13.5 17 5.7 10.2 2.9 2 1 1 3 3 3 0 4Fe-4S dicluster domain DUF3149 PF11346.8 EMD62041.1 - 0.036 13.7 1.2 0.053 13.1 1.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3149) YukC PF10140.9 EMD62041.1 - 0.048 12.5 0.0 0.053 12.4 0.0 1.0 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukC Flavi_M PF01004.19 EMD62041.1 - 0.054 13.3 0.2 0.088 12.6 0.2 1.5 1 1 0 1 1 1 0 Flavivirus envelope glycoprotein M PDR_CDR PF06422.12 EMD62041.1 - 0.064 13.2 0.0 0.067 13.1 0.0 1.1 1 0 0 1 1 1 0 CDR ABC transporter SMP_2 PF10144.9 EMD62041.1 - 0.1 12.3 0.1 0.11 12.1 0.1 1.2 1 0 0 1 1 1 0 Bacterial virulence factor haemolysin DUF4448 PF14610.6 EMD62041.1 - 0.18 11.5 0.1 0.18 11.5 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) RCR PF12273.8 EMD62041.1 - 0.32 11.6 1.7 0.45 11.2 1.7 1.2 1 0 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red FeoB_associated PF12669.7 EMD62041.1 - 0.61 10.5 2.6 0.82 10.1 2.6 1.2 1 0 0 1 1 1 0 FeoB-associated Cys-rich membrane protein APG5 PF04106.12 EMD62042.1 - 1.2e-60 204.9 0.0 1.7e-60 204.5 0.0 1.2 1 0 0 1 1 1 1 Autophagy protein Apg5 cobW PF02492.19 EMD62044.1 - 3.1e-41 140.9 0.0 4.5e-41 140.4 0.0 1.2 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain MobB PF03205.14 EMD62044.1 - 0.00082 19.3 0.0 0.0016 18.3 0.0 1.5 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B CobW_C PF07683.14 EMD62044.1 - 0.0035 17.2 0.0 0.06 13.3 0.0 2.7 2 1 0 2 2 2 1 Cobalamin synthesis protein cobW C-terminal domain AAA_22 PF13401.6 EMD62044.1 - 0.011 16.0 0.0 0.045 14.0 0.0 2.0 2 0 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 EMD62044.1 - 0.014 15.3 0.1 3.3 7.6 0.0 2.4 2 0 0 2 2 2 0 RsgA GTPase AAA_29 PF13555.6 EMD62044.1 - 0.019 14.7 0.2 0.42 10.4 0.1 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_18 PF13238.6 EMD62044.1 - 0.04 14.5 0.2 0.14 12.7 0.2 1.9 1 1 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.18 EMD62044.1 - 0.051 13.3 0.0 0.094 12.4 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Endonuclease_7 PF02945.15 EMD62044.1 - 1 9.4 2.9 27 4.8 0.4 2.3 2 0 0 2 2 2 0 Recombination endonuclease VII MT0933_antitox PF14013.6 EMD62045.1 - 0.66 10.3 7.8 0.65 10.3 3.0 2.9 2 1 0 2 2 2 0 MT0933-like antitoxin protein MutS_V PF00488.21 EMD62046.1 - 4.8e-71 238.7 0.0 1e-70 237.6 0.0 1.6 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 EMD62046.1 - 1.2e-35 123.5 1.9 1.2e-35 123.5 1.9 2.1 2 0 0 2 2 2 1 MutS domain III MutS_I PF01624.20 EMD62046.1 - 9.2e-30 103.2 0.1 2.1e-29 102.1 0.1 1.6 1 0 0 1 1 1 1 MutS domain I MutS_II PF05188.17 EMD62046.1 - 3.7e-11 43.4 0.0 1.5e-10 41.5 0.0 2.1 1 0 0 1 1 1 1 MutS domain II MutS_IV PF05190.18 EMD62046.1 - 2.5e-07 30.9 0.2 1.5e-06 28.4 0.3 2.4 2 0 0 2 2 2 1 MutS family domain IV DUF4911 PF16256.5 EMD62046.1 - 0.025 14.6 0.2 0.12 12.4 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4911) G_glu_transpept PF01019.21 EMD62047.1 - 5.1e-163 543.5 0.7 5.8e-163 543.3 0.7 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase DUF642 PF04862.12 EMD62047.1 - 0.013 15.3 0.0 0.13 12.0 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF642) TPR_14 PF13428.6 EMD62048.1 - 7.2e-14 51.3 5.2 0.007 17.1 0.8 6.8 6 1 1 7 7 7 3 Tetratricopeptide repeat Suf PF05843.14 EMD62048.1 - 5e-10 39.8 7.9 5.6e-05 23.3 0.3 3.7 3 1 1 4 4 4 3 Suppressor of forked protein (Suf) TPR_19 PF14559.6 EMD62048.1 - 3.1e-05 24.4 0.3 1.1 9.9 0.1 3.5 2 1 1 3 3 3 3 Tetratricopeptide repeat SUKH-3 PF14433.6 EMD62048.1 - 0.04 14.4 1.0 0.29 11.6 0.2 2.6 3 0 0 3 3 3 0 SUKH-3 immunity protein TPR_12 PF13424.6 EMD62048.1 - 0.044 14.1 3.0 0.3 11.4 0.3 3.3 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 EMD62048.1 - 4.8 8.0 9.9 37 5.2 0.2 5.5 7 0 0 7 7 7 0 Tetratricopeptide repeat Fungal_trans_2 PF11951.8 EMD62050.1 - 4.7e-90 302.2 0.1 6.7e-90 301.7 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD62050.1 - 5.3e-08 32.9 9.1 9.1e-08 32.1 9.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SAM_2 PF07647.17 EMD62051.1 - 1.6e-10 40.9 0.6 3e-10 40.0 0.2 1.7 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 EMD62051.1 - 8.2e-07 29.4 0.4 2e-06 28.2 0.4 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_3 PF18016.1 EMD62051.1 - 0.00028 20.7 0.0 0.00086 19.1 0.0 1.8 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PH PF00169.29 EMD62051.1 - 0.00029 21.3 0.0 0.0007 20.1 0.0 1.7 1 0 0 1 1 1 1 PH domain SAM_PNT PF02198.16 EMD62051.1 - 0.1 12.6 0.2 0.21 11.6 0.2 1.5 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain tRNA-synt_1g PF09334.11 EMD62053.1 - 7.1e-95 318.0 0.1 1.5e-93 313.6 0.1 2.0 1 1 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 EMD62053.1 - 9.4e-23 80.3 1.8 1.1e-09 37.1 0.0 3.7 2 2 1 3 3 3 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.19 EMD62053.1 - 5e-05 22.8 0.0 0.1 11.9 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain Anticodon_1 PF08264.13 EMD62053.1 - 0.0046 16.9 0.0 0.019 14.9 0.0 1.9 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA tRNA-synt_1f PF01921.18 EMD62053.1 - 0.012 14.6 0.0 0.021 13.7 0.0 1.4 1 0 0 1 1 1 0 tRNA synthetases class I (K) G-patch_2 PF12656.7 EMD62054.1 - 9e-24 83.3 0.5 9e-24 83.3 0.5 3.7 4 0 0 4 4 4 1 G-patch domain G-patch PF01585.23 EMD62054.1 - 2.1e-05 24.3 0.9 5.4e-05 23.0 0.9 1.8 1 0 0 1 1 1 1 G-patch domain Frag1 PF10277.9 EMD62055.1 - 2.9e-46 157.8 24.4 3.3e-46 157.6 24.4 1.0 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family DUF998 PF06197.13 EMD62055.1 - 0.0017 18.0 4.6 0.0023 17.6 3.6 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF998) TMEM220 PF15071.6 EMD62055.1 - 0.42 11.4 7.0 4 8.3 0.3 2.9 3 0 0 3 3 3 0 Transmembrane family 220, helix DUF2070 PF09843.9 EMD62055.1 - 1.2 7.4 8.4 1.7 6.9 8.4 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Orn_Arg_deC_N PF02784.16 EMD62057.1 - 2.3e-84 282.6 0.0 3.4e-84 282.1 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.22 EMD62057.1 - 3.5e-20 72.1 0.0 3.8e-20 71.9 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain AP_endonuc_2 PF01261.24 EMD62057.1 - 0.11 11.9 0.0 0.22 11.0 0.0 1.4 1 0 0 1 1 1 0 Xylose isomerase-like TIM barrel IGR PF09597.10 EMD62058.1 - 2.7e-25 88.2 0.0 5.3e-25 87.3 0.0 1.5 1 0 0 1 1 1 1 IGR protein motif WD40 PF00400.32 EMD62059.1 - 4e-15 55.9 14.7 0.00014 22.6 0.2 6.4 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD62059.1 - 8.7e-08 32.4 0.1 0.041 14.2 0.0 4.9 5 1 1 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 EMD62059.1 - 0.003 17.5 0.1 0.38 10.8 0.1 2.9 2 0 0 2 2 2 1 WD40-like Beta Propeller Repeat Zn_clus PF00172.18 EMD62060.1 - 0.00011 22.3 8.2 0.0002 21.4 8.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF5327 PF17261.2 EMD62060.1 - 2.3 9.0 6.0 1.2 9.9 0.3 2.9 2 1 1 3 3 3 0 Family of unknown function (DUF5327) Zn_clus PF00172.18 EMD62062.1 - 0.002 18.2 10.0 0.0037 17.3 10.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-LYAR PF08790.11 EMD62063.1 - 2.8e-14 52.7 3.7 2.8e-14 52.7 3.7 2.2 2 0 0 2 2 2 1 LYAR-type C2HC zinc finger TMEM215 PF15746.5 EMD62063.1 - 0.46 9.9 5.6 0.76 9.2 4.7 1.9 1 1 1 2 2 2 0 TMEM215 family Evr1_Alr PF04777.13 EMD62064.1 - 2.1e-26 92.3 0.1 2.6e-26 92.0 0.1 1.1 1 0 0 1 1 1 1 Erv1 / Alr family Aminotran_4 PF01063.19 EMD62065.1 - 4.8e-23 82.2 0.0 6.1e-23 81.8 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV Peptidase_C48 PF02902.19 EMD62066.1 - 1.6e-16 60.8 0.0 1.3e-15 57.8 0.0 2.3 1 1 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain Glyco_hydro_47 PF01532.20 EMD62067.1 - 3.9e-169 563.4 0.1 5.1e-169 563.0 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Ribosomal_L38e PF01781.18 EMD62068.1 - 1.6e-31 108.2 3.0 1.8e-31 108.0 3.0 1.1 1 0 0 1 1 1 1 Ribosomal L38e protein family DUF5374 PF17344.2 EMD62068.1 - 0.067 13.1 0.1 0.095 12.6 0.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5374) SAM_PNT PF02198.16 EMD62069.1 - 0.12 12.3 1.4 0.18 11.8 1.4 1.3 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain ATG16 PF08614.11 EMD62070.1 - 0.0027 18.0 5.1 0.0027 18.0 5.1 2.1 2 0 0 2 2 2 1 Autophagy protein 16 (ATG16) Iso_dh PF00180.20 EMD62071.1 - 9.2e-84 281.5 0.0 1.1e-83 281.2 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase WBS_methylT PF12589.8 EMD62072.1 - 3e-14 53.5 5.9 5.3e-14 52.7 5.9 1.4 1 0 0 1 1 1 1 Methyltransferase involved in Williams-Beuren syndrome Methyltransf_11 PF08241.12 EMD62072.1 - 2.1e-10 41.1 0.0 4.1e-10 40.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMD62072.1 - 3.7e-09 37.2 0.0 9.9e-09 35.8 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMD62072.1 - 8.1e-05 23.3 0.0 0.00018 22.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMD62072.1 - 0.00072 19.4 0.0 0.0016 18.3 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 EMD62072.1 - 0.0044 16.8 0.0 0.012 15.4 0.0 1.6 2 0 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_23 PF13489.6 EMD62072.1 - 0.0047 16.8 0.0 0.008 16.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EMD62072.1 - 0.0074 15.6 0.0 0.76 9.0 0.0 2.2 2 0 0 2 2 2 2 Mycolic acid cyclopropane synthetase Erv26 PF04148.13 EMD62073.1 - 3.4e-92 307.9 0.0 4e-92 307.7 0.0 1.0 1 0 0 1 1 1 1 Transmembrane adaptor Erv26 NatB_MDM20 PF09797.9 EMD62074.1 - 7.3e-19 67.9 0.0 1.6e-18 66.9 0.0 1.5 1 0 0 1 1 1 1 N-acetyltransferase B complex (NatB) non catalytic subunit Nuc_deoxyri_tr2 PF15891.5 EMD62075.1 - 1.4e-35 121.8 0.1 1e-34 119.1 0.0 2.0 2 0 0 2 2 2 1 Nucleoside 2-deoxyribosyltransferase like Prefoldin_2 PF01920.20 EMD62075.1 - 0.038 13.9 2.1 0.085 12.8 2.1 1.6 1 0 0 1 1 1 0 Prefoldin subunit FlxA PF14282.6 EMD62075.1 - 0.043 13.8 2.9 0.062 13.3 2.1 1.6 2 0 0 2 2 2 0 FlxA-like protein DUF5320 PF17253.2 EMD62075.1 - 0.16 13.1 0.7 0.39 11.8 0.7 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5320) Sbi-IV PF11621.8 EMD62075.1 - 0.2 12.1 1.5 0.39 11.1 1.5 1.5 1 0 0 1 1 1 0 C3 binding domain 4 of IgG-bind protein SBI PIN_11 PF18479.1 EMD62077.1 - 0.13 12.4 0.1 0.17 12.1 0.1 1.3 1 0 0 1 1 1 0 PIN like domain DUF4734 PF15881.5 EMD62077.1 - 5 7.4 10.5 20 5.4 9.0 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4734) AIG2_2 PF13772.6 EMD62078.1 - 9e-05 22.8 0.1 0.00029 21.1 0.1 1.9 1 1 0 1 1 1 1 AIG2-like family Glyco_hydro_16 PF00722.21 EMD62079.1 - 6.7e-08 32.2 0.5 5.2e-07 29.3 0.5 2.1 1 1 0 1 1 1 1 Glycosyl hydrolases family 16 Acyl_transf_3 PF01757.22 EMD62079.1 - 3.3e-07 29.7 32.1 6.3e-07 28.8 32.1 1.4 1 0 0 1 1 1 1 Acyltransferase family Glyco_trans_2_3 PF13632.6 EMD62080.1 - 6.7e-23 81.6 4.5 6.7e-23 81.6 4.5 2.3 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 EMD62080.1 - 9.8e-20 71.4 0.0 1.4e-19 70.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 EMD62080.1 - 6.7e-08 32.2 0.0 9.7e-08 31.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.26 EMD62080.1 - 4.2e-05 23.4 0.0 6.4e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 MFS_1 PF07690.16 EMD62082.1 - 2.8e-26 92.3 39.5 4.8e-26 91.5 39.5 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily CorA PF01544.18 EMD62083.1 - 9.2e-13 48.2 0.2 2.2e-12 46.9 0.2 1.6 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein Trimer_CC PF08954.11 EMD62083.1 - 0.053 13.1 0.0 0.16 11.5 0.0 1.8 1 0 0 1 1 1 0 Trimerisation motif CopD PF05425.13 EMD62083.1 - 0.074 13.5 1.7 0.14 12.5 1.7 1.4 1 0 0 1 1 1 0 Copper resistance protein D AMP-binding PF00501.28 EMD62084.1 - 4.2e-64 216.7 0.0 8.6e-64 215.7 0.0 1.4 1 1 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EMD62084.1 - 3.1e-08 34.5 0.0 1.1e-07 32.7 0.0 2.0 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain TUG-UBL1 PF11470.8 EMD62085.1 - 1.2e-24 86.3 0.4 8.8e-24 83.5 0.1 2.5 3 0 0 3 3 3 1 TUG ubiquitin-like domain UBX PF00789.20 EMD62085.1 - 8.7e-11 41.9 0.0 6e-10 39.2 0.0 2.4 2 0 0 2 2 2 1 UBX domain ubiquitin PF00240.23 EMD62085.1 - 0.011 15.5 0.0 0.036 13.8 0.0 2.0 2 0 0 2 2 2 0 Ubiquitin family PITH PF06201.13 EMD62086.1 - 7.8e-40 136.6 0.3 5.7e-39 133.8 0.0 2.0 2 0 0 2 2 2 1 PITH domain Thioredoxin PF00085.20 EMD62086.1 - 1.3e-15 57.2 0.0 2.6e-15 56.3 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 EMD62086.1 - 0.0036 17.7 0.1 0.0093 16.4 0.0 1.7 2 0 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 EMD62086.1 - 0.015 15.6 0.4 1.3 9.3 0.1 2.4 1 1 1 2 2 2 0 Thioredoxin-like Thioredoxin_6 PF13848.6 EMD62086.1 - 0.046 13.6 0.1 0.092 12.6 0.1 1.4 1 0 0 1 1 1 0 Thioredoxin-like domain OST3_OST6 PF04756.13 EMD62086.1 - 0.069 12.5 0.2 0.14 11.5 0.2 1.4 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family Ribosomal_L36e PF01158.18 EMD62087.1 - 1.9e-39 133.8 3.7 2.2e-39 133.6 3.7 1.0 1 0 0 1 1 1 1 Ribosomal protein L36e MRP-L28 PF09812.9 EMD62087.1 - 0.12 12.5 1.2 0.14 12.3 1.2 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L28 AMP-binding PF00501.28 EMD62088.1 - 6.8e-99 331.3 0.0 8.1e-99 331.1 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EMD62088.1 - 2.6e-15 57.1 0.0 6.3e-15 55.9 0.0 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain 4HBT_3 PF13622.6 EMD62089.1 - 2.6e-52 178.6 0.0 3e-52 178.4 0.0 1.0 1 0 0 1 1 1 1 Thioesterase-like superfamily 4HBT PF03061.22 EMD62089.1 - 0.00023 21.5 0.1 0.34 11.3 0.1 2.2 2 0 0 2 2 2 2 Thioesterase superfamily EXS PF03124.14 EMD62091.1 - 1e-111 373.5 7.0 1.2e-111 373.3 7.0 1.0 1 0 0 1 1 1 1 EXS family Sigma70_r4_2 PF08281.12 EMD62092.1 - 0.12 12.1 0.0 0.28 10.9 0.0 1.6 1 0 0 1 1 1 0 Sigma-70, region 4 TetR_N PF00440.23 EMD62092.1 - 0.15 11.9 0.3 0.52 10.2 0.1 2.0 2 0 0 2 2 2 0 Bacterial regulatory proteins, tetR family N-SET PF11764.8 EMD62093.1 - 1e-54 185.3 6.3 1e-54 185.3 6.3 3.7 3 0 0 3 3 3 2 COMPASS (Complex proteins associated with Set1p) component N SET_assoc PF11767.8 EMD62093.1 - 1.3e-26 92.0 2.0 2.1e-26 91.4 0.9 2.0 2 0 0 2 2 2 1 Histone lysine methyltransferase SET associated SET PF00856.28 EMD62093.1 - 6.9e-20 72.1 0.1 6.9e-20 72.1 0.1 3.9 3 1 0 3 3 3 1 SET domain RRM_1 PF00076.22 EMD62093.1 - 0.0013 18.5 0.0 0.0035 17.1 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Cutinase PF01083.22 EMD62093.1 - 0.15 12.0 0.0 0.36 10.8 0.0 1.5 1 0 0 1 1 1 0 Cutinase DMRL_synthase PF00885.19 EMD62094.1 - 2e-56 189.7 0.0 2.7e-56 189.3 0.0 1.2 1 0 0 1 1 1 1 6,7-dimethyl-8-ribityllumazine synthase SIS PF01380.22 EMD62095.1 - 1.3e-57 193.3 0.0 4.8e-31 107.3 0.0 2.3 2 0 0 2 2 2 2 SIS domain GATase_6 PF13522.6 EMD62095.1 - 1.1e-16 61.2 0.0 2.1e-16 60.3 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 EMD62095.1 - 1.2e-10 41.3 0.0 2.8e-10 40.2 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.6 EMD62095.1 - 0.001 18.1 0.0 0.0018 17.3 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferases class-II SIS_2 PF13580.6 EMD62095.1 - 0.04 13.9 0.0 1 9.4 0.0 2.5 2 0 0 2 2 2 0 SIS domain Holin_BhlA PF10960.8 EMD62095.1 - 0.14 12.1 0.0 0.44 10.6 0.0 1.8 1 0 0 1 1 1 0 BhlA holin family PG_binding_1 PF01471.18 EMD62095.1 - 0.17 12.2 0.1 0.64 10.3 0.0 2.0 2 0 0 2 2 2 0 Putative peptidoglycan binding domain Aa_trans PF01490.18 EMD62097.1 - 1.4e-83 280.9 32.1 1.7e-83 280.6 32.1 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Ac81 PF05820.11 EMD62097.1 - 2 8.0 5.1 4.2 6.9 5.1 1.5 1 0 0 1 1 1 0 Baculoviridae AC81 AA_permease PF00324.21 EMD62098.1 - 1.5e-62 211.8 31.8 1.8e-62 211.5 31.8 1.1 1 0 0 1 1 1 1 Amino acid permease SLC12 PF03522.15 EMD62098.1 - 1.6e-24 86.8 0.2 5e-10 39.0 0.0 3.3 3 0 0 3 3 3 3 Solute carrier family 12 AA_permease_2 PF13520.6 EMD62098.1 - 3.7e-18 65.6 38.3 5.1e-18 65.1 38.3 1.1 1 0 0 1 1 1 1 Amino acid permease DUF2975 PF11188.8 EMD62098.1 - 0.05 13.5 0.3 0.05 13.5 0.3 2.9 4 0 0 4 4 4 0 Protein of unknown function (DUF2975) WD40 PF00400.32 EMD62099.1 - 9.2e-11 42.1 0.5 0.32 11.9 0.2 6.8 7 0 0 7 7 7 3 WD domain, G-beta repeat Nucleoporin_N PF08801.11 EMD62099.1 - 0.11 11.3 0.4 24 3.5 0.0 2.8 1 1 1 3 3 3 0 Nup133 N terminal like DUF484 PF04340.12 EMD62099.1 - 0.14 11.8 0.0 0.27 10.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF484 HSA PF07529.13 EMD62100.1 - 6.4e-13 48.8 0.2 6.4e-13 48.8 0.2 4.6 4 0 0 4 4 4 1 HSA Myb_DNA-bind_6 PF13921.6 EMD62100.1 - 7.4e-13 48.5 0.5 7.4e-13 48.5 0.5 3.1 3 0 0 3 3 3 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 EMD62100.1 - 0.0004 20.5 0.9 0.0015 18.7 0.9 2.1 1 0 0 1 1 1 1 Myb-like DNA-binding domain RNA_pol_L_2 PF13656.6 EMD62101.1 - 1e-25 89.3 0.0 1.3e-25 88.9 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 EMD62101.1 - 1.2e-08 34.2 0.0 1.7e-08 33.8 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain R3H PF01424.22 EMD62102.1 - 1.7e-16 59.9 0.0 3.4e-16 59.0 0.0 1.5 1 0 0 1 1 1 1 R3H domain zf-NF-X1 PF01422.17 EMD62102.1 - 1.6e-07 31.2 64.6 2.6e-05 24.1 17.3 12.1 13 1 0 13 13 13 6 NF-X1 type zinc finger ATP-synt_S1 PF05827.12 EMD62103.1 - 0.0043 16.9 0.6 0.0074 16.1 0.6 1.4 1 1 0 1 1 1 1 Vacuolar ATP synthase subunit S1 (ATP6S1) TMEM18 PF14770.6 EMD62103.1 - 0.14 12.2 0.1 0.23 11.5 0.1 1.3 1 0 0 1 1 1 0 Transmembrane protein 18 ATPase PF06745.13 EMD62103.1 - 0.18 11.1 0.0 0.26 10.6 0.0 1.2 1 0 0 1 1 1 0 KaiC FAD_binding_3 PF01494.19 EMD62104.1 - 8.1e-13 48.3 0.0 2e-12 47.1 0.0 1.7 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EMD62104.1 - 8.8e-06 25.2 0.1 0.046 13.0 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EMD62104.1 - 9e-06 25.5 0.1 5e-05 23.0 0.1 2.0 2 1 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EMD62104.1 - 0.0023 18.1 0.0 0.0059 16.8 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 EMD62104.1 - 0.015 15.3 0.0 3.1 7.8 0.0 3.0 3 0 0 3 3 3 0 FAD-NAD(P)-binding Trp_halogenase PF04820.14 EMD62104.1 - 0.076 11.9 0.3 0.57 9.0 0.0 2.1 2 0 0 2 2 2 0 Tryptophan halogenase Pyr_redox PF00070.27 EMD62104.1 - 0.096 13.3 0.1 22 5.7 0.0 2.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EMD62104.1 - 0.13 11.4 0.3 0.22 10.6 0.3 1.4 1 0 0 1 1 1 0 FAD binding domain Glyco_hydro_10 PF00331.20 EMD62106.1 - 8.9e-99 330.6 2.1 1e-98 330.4 2.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 10 p450 PF00067.22 EMD62107.1 - 3.4e-53 181.1 0.0 5.5e-53 180.3 0.0 1.2 1 1 0 1 1 1 1 Cytochrome P450 SnoaL_4 PF13577.6 EMD62108.1 - 1.5e-24 86.5 0.0 2e-24 86.1 0.0 1.1 1 0 0 1 1 1 1 SnoaL-like domain DUF3225 PF11533.8 EMD62108.1 - 0.0017 18.1 0.0 0.0026 17.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3225) Lumazine_bd_2 PF12893.7 EMD62108.1 - 0.002 18.8 0.0 0.0072 17.0 0.0 1.9 1 1 1 2 2 2 1 Putative lumazine-binding SnoaL_2 PF12680.7 EMD62108.1 - 0.0043 17.7 0.0 0.0077 16.9 0.0 1.5 1 1 0 1 1 1 1 SnoaL-like domain DUF4440 PF14534.6 EMD62108.1 - 0.012 16.0 0.0 0.017 15.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4440) Scytalone_dh PF02982.14 EMD62108.1 - 0.02 14.7 0.0 0.034 13.9 0.0 1.4 1 0 0 1 1 1 0 Scytalone dehydratase SnoaL PF07366.12 EMD62108.1 - 0.042 13.7 0.0 0.075 12.8 0.0 1.6 1 1 0 1 1 1 0 SnoaL-like polyketide cyclase TPR_10 PF13374.6 EMD62110.1 - 7.6e-79 257.7 11.7 5.2e-13 48.4 0.0 7.8 7 0 0 7 7 7 7 Tetratricopeptide repeat TPR_12 PF13424.6 EMD62110.1 - 2.4e-61 203.9 20.2 3.1e-14 53.0 0.2 6.6 2 1 4 6 6 6 6 Tetratricopeptide repeat TPR_7 PF13176.6 EMD62110.1 - 2.5e-20 71.0 7.1 0.019 15.0 0.0 8.1 7 0 0 7 7 7 5 Tetratricopeptide repeat NB-ARC PF00931.22 EMD62110.1 - 1.2e-14 54.1 0.0 3e-14 52.8 0.0 1.7 1 0 0 1 1 1 1 NB-ARC domain HET PF06985.11 EMD62110.1 - 3.2e-12 47.0 8.7 1e-08 35.6 4.7 3.4 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) TPR_17 PF13431.6 EMD62110.1 - 5.5e-12 45.2 8.5 0.34 11.4 0.0 7.9 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_2 PF07719.17 EMD62110.1 - 1.8e-11 43.2 10.3 0.45 10.8 0.0 8.2 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_4 PF07721.14 EMD62110.1 - 2.1e-11 43.3 0.3 1.1 10.1 0.0 7.4 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_1 PF00515.28 EMD62110.1 - 1.5e-09 37.2 8.1 0.56 10.1 0.1 6.9 7 0 0 7 7 7 3 Tetratricopeptide repeat AAA_16 PF13191.6 EMD62110.1 - 6.8e-09 36.3 2.8 2.9e-08 34.3 0.0 2.8 3 0 0 3 3 2 1 AAA ATPase domain TPR_16 PF13432.6 EMD62110.1 - 3.1e-08 34.1 0.1 11 6.7 0.0 6.7 6 1 1 7 7 6 0 Tetratricopeptide repeat TPR_MalT PF17874.1 EMD62110.1 - 1.6e-07 31.0 18.3 1.4e-05 24.7 5.7 3.5 1 1 3 4 4 4 2 MalT-like TPR region AAA_22 PF13401.6 EMD62110.1 - 8.6e-07 29.3 0.0 4.3e-06 27.1 0.0 2.3 1 0 0 1 1 1 1 AAA domain TPR_19 PF14559.6 EMD62110.1 - 5.9e-06 26.7 6.4 3.9 8.1 0.0 6.8 5 1 3 8 8 7 1 Tetratricopeptide repeat TniB PF05621.11 EMD62110.1 - 6.3e-05 22.5 0.0 0.001 18.5 0.0 2.3 2 0 0 2 2 2 1 Bacterial TniB protein DnaB_C PF03796.15 EMD62110.1 - 0.001 18.5 0.0 0.0032 16.8 0.0 1.9 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain TPR_8 PF13181.6 EMD62110.1 - 0.0012 18.9 9.9 5.3 7.5 0.1 7.2 8 0 0 8 8 7 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EMD62110.1 - 0.0013 18.9 6.5 9.4 6.5 0.1 6.3 2 1 4 6 6 6 0 Anaphase-promoting complex, cyclosome, subunit 3 ATPase_2 PF01637.18 EMD62110.1 - 0.0017 18.3 0.0 0.0052 16.7 0.0 1.8 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea FlgT_M PF16539.5 EMD62110.1 - 0.012 15.8 5.2 0.86 9.7 0.3 3.7 1 1 2 3 3 3 0 Flagellar assembly protein T, middle domain TPR_3 PF07720.12 EMD62110.1 - 0.019 14.9 1.7 13 5.9 0.1 4.3 5 0 0 5 5 3 0 Tetratricopeptide repeat AAA PF00004.29 EMD62110.1 - 0.022 15.2 0.0 0.084 13.3 0.0 2.1 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.17 EMD62110.1 - 0.03 14.0 0.0 0.08 12.7 0.0 1.7 1 0 0 1 1 1 0 IstB-like ATP binding protein SRP54 PF00448.22 EMD62110.1 - 0.12 12.0 0.0 0.33 10.5 0.0 1.8 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain PhoH PF02562.16 EMD62110.1 - 0.12 11.8 0.0 0.29 10.6 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein TPR_6 PF13174.6 EMD62110.1 - 2.3 9.0 12.1 80 4.2 0.2 6.4 7 0 0 7 7 6 0 Tetratricopeptide repeat PPR PF01535.20 EMD62110.1 - 7.5 7.1 7.9 33 5.0 0.0 5.2 7 0 0 7 7 5 0 PPR repeat Thioredoxin_7 PF13899.6 EMD62111.1 - 2.8e-18 65.9 0.1 2.3e-17 62.9 0.1 2.2 2 0 0 2 2 2 1 Thioredoxin-like UBA_4 PF14555.6 EMD62111.1 - 4.3e-14 52.1 0.0 1.1e-13 50.8 0.0 1.7 1 0 0 1 1 1 1 UBA-like domain UBX PF00789.20 EMD62111.1 - 2.9e-07 30.6 0.0 1e-06 28.8 0.0 2.0 2 0 0 2 2 2 1 UBX domain Thioredoxin_2 PF13098.6 EMD62111.1 - 0.012 16.1 0.0 0.025 15.0 0.0 1.6 1 0 0 1 1 1 0 Thioredoxin-like domain Ecm29 PF13001.7 EMD62112.1 - 9.7e-162 539.1 0.9 6.6e-161 536.4 0.1 2.6 2 0 0 2 2 2 1 Proteasome stabiliser HEAT PF02985.22 EMD62112.1 - 1.3e-07 31.2 3.4 1.3 9.5 0.1 8.2 8 0 0 8 8 8 2 HEAT repeat Vac14_Fab1_bd PF12755.7 EMD62112.1 - 2.3e-06 28.1 0.5 0.017 15.7 0.1 5.1 5 0 0 5 5 5 1 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 EMD62112.1 - 0.00012 22.5 5.4 24 5.6 0.0 7.4 7 0 0 7 7 7 0 HEAT-like repeat MMS19_C PF12460.8 EMD62112.1 - 0.01 15.0 8.1 0.079 12.1 0.5 4.3 5 0 0 5 5 5 0 RNAPII transcription regulator C-terminal CLASP_N PF12348.8 EMD62112.1 - 0.11 12.0 0.0 3.2 7.3 0.0 3.0 2 0 0 2 2 2 0 CLASP N terminal IFRD PF05004.13 EMD62112.1 - 0.14 11.2 3.9 2.7 7.0 0.0 4.4 5 0 0 5 5 5 0 Interferon-related developmental regulator (IFRD) MOR2-PAG1_N PF14222.6 EMD62112.1 - 0.15 11.0 1.0 3.3 6.5 0.0 3.6 5 0 0 5 5 5 0 Cell morphogenesis N-terminal Ldh_1_N PF00056.23 EMD62113.1 - 1.7e-34 118.9 0.0 2.7e-34 118.3 0.0 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 EMD62113.1 - 2.1e-20 73.3 0.0 3e-20 72.8 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain TrkA_N PF02254.18 EMD62113.1 - 0.00035 20.8 0.1 0.00072 19.8 0.1 1.5 1 0 0 1 1 1 1 TrkA-N domain ApbA PF02558.16 EMD62113.1 - 0.0038 16.9 0.1 0.0069 16.0 0.1 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA F420_oxidored PF03807.17 EMD62113.1 - 0.0056 17.2 0.2 0.026 15.1 0.1 2.2 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent DAO PF01266.24 EMD62113.1 - 0.17 11.4 1.4 4.7 6.7 0.1 2.2 1 1 1 2 2 2 0 FAD dependent oxidoreductase Pkinase PF00069.25 EMD62114.1 - 7.6e-20 71.4 0.0 1.1e-19 70.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD62114.1 - 1.6e-05 24.4 0.0 2.2e-05 23.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EMD62114.1 - 0.0024 17.2 0.1 0.0036 16.7 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family DUF3189 PF11385.8 EMD62115.1 - 0.11 12.3 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3189) DUF2700 PF10912.8 EMD62119.1 - 0.0013 18.8 3.1 0.23 11.5 0.0 2.7 3 0 0 3 3 3 2 Protein of unknown function (DUF2700) SUa-2TM PF18179.1 EMD62119.1 - 0.015 14.6 0.0 0.031 13.6 0.0 1.4 1 0 0 1 1 1 0 SMODS- and Ubiquitin system-associated 2TM effector domain MARVEL PF01284.23 EMD62119.1 - 0.025 14.6 13.6 0.017 15.2 11.0 1.9 1 1 1 2 2 2 0 Membrane-associating domain DUF588 PF04535.12 EMD62119.1 - 0.04 13.7 3.7 0.057 13.2 3.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF588) DUF3290 PF11694.8 EMD62119.1 - 0.099 12.6 0.1 0.099 12.6 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3290) Cation_efflux PF01545.21 EMD62119.1 - 0.24 11.1 7.4 0.73 9.5 7.4 1.9 1 1 0 1 1 1 0 Cation efflux family DUF4381 PF14316.6 EMD62119.1 - 1.3 9.3 3.5 19 5.5 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4381) DUF2157 PF09925.9 EMD62119.1 - 2.2 8.1 7.8 1.4 8.7 4.7 2.2 2 1 0 2 2 2 0 Predicted membrane protein (DUF2157) DUF4271 PF14093.6 EMD62119.1 - 2.9 7.8 11.5 0.19 11.7 4.6 2.3 2 1 1 3 3 3 0 Domain of unknown function (DUF4271) Vpu PF00558.19 EMD62119.1 - 3.5 7.5 9.0 11 5.9 1.5 2.9 2 1 1 3 3 3 0 Vpu protein 7TMR-DISM_7TM PF07695.11 EMD62119.1 - 4.8 7.0 11.7 0.27 11.1 6.0 1.7 2 0 0 2 2 2 0 7TM diverse intracellular signalling Tetraspanin PF00335.20 EMD62119.1 - 7.7 6.2 10.8 6.5 6.4 7.4 2.0 1 1 1 2 2 2 0 Tetraspanin family HET PF06985.11 EMD62120.1 - 6.1e-27 94.8 0.0 8.8e-27 94.3 0.0 1.2 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Peptidase_M19 PF01244.21 EMD62122.1 - 4e-103 344.9 0.0 4.7e-103 344.7 0.0 1.0 1 0 0 1 1 1 1 Membrane dipeptidase (Peptidase family M19) Ilm1 PF10311.9 EMD62123.1 - 2e-53 180.4 0.2 2.4e-53 180.2 0.2 1.0 1 0 0 1 1 1 1 Increased loss of mitochondrial DNA protein 1 TadE PF07811.12 EMD62123.1 - 1.2 9.5 5.3 1.5 9.1 0.2 3.0 3 0 0 3 3 3 0 TadE-like protein MOSC PF03473.17 EMD62124.1 - 3.5e-35 120.9 0.0 7.1e-35 119.9 0.0 1.6 1 0 0 1 1 1 1 MOSC domain MOSC_N PF03476.16 EMD62124.1 - 4e-24 84.8 0.0 7.6e-24 83.9 0.0 1.5 1 0 0 1 1 1 1 MOSC N-terminal beta barrel domain Aminotran_5 PF00266.19 EMD62124.1 - 3.5e-22 78.9 0.0 1.1e-21 77.3 0.0 1.9 1 1 0 1 1 1 1 Aminotransferase class-V RGS12_us1 PF16613.5 EMD62126.1 - 0.011 16.0 1.3 0.011 16.0 1.3 2.5 2 1 0 2 2 2 0 Unstructured region of RGS12 DUF1388 PF07142.12 EMD62126.1 - 0.72 9.9 20.0 0.79 9.7 3.4 5.2 5 0 0 5 5 5 0 Repeat of unknown function (DUF1388) TFIIF_alpha PF05793.12 EMD62126.1 - 1.2 7.6 6.0 1.4 7.4 6.0 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) HIRA_B PF09453.10 EMD62127.1 - 0.051 13.4 0.1 0.1 12.5 0.1 1.5 1 0 0 1 1 1 0 HIRA B motif DUF308 PF03729.13 EMD62127.1 - 3.4 8.1 12.1 2.8 8.3 0.3 3.7 3 0 0 3 3 3 0 Short repeat of unknown function (DUF308) SHR3_chaperone PF08229.11 EMD62129.1 - 9.3e-74 246.5 0.2 1.1e-73 246.3 0.2 1.0 1 0 0 1 1 1 1 ER membrane protein SH3 DUF5453 PF17534.2 EMD62129.1 - 0.022 14.7 1.0 0.022 14.7 1.0 2.4 1 1 1 2 2 2 0 Family of unknown function (DUF5453) MCM PF00493.23 EMD62130.1 - 9e-104 345.4 0.0 1.3e-103 344.9 0.0 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EMD62130.1 - 1.2e-32 112.4 0.4 2.3e-32 111.5 0.4 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_N PF14551.6 EMD62130.1 - 7.3e-20 71.5 1.1 1.6e-19 70.4 1.1 1.6 1 0 0 1 1 1 1 MCM N-terminal domain MCM_lid PF17855.1 EMD62130.1 - 1.5e-17 63.8 0.2 4.2e-17 62.3 0.2 1.8 1 0 0 1 1 1 1 MCM AAA-lid domain Mg_chelatase PF01078.21 EMD62130.1 - 3.1e-07 30.0 0.0 2.8e-05 23.6 0.0 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EMD62130.1 - 4.6e-06 26.7 0.0 1.1e-05 25.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_lid_2 PF17863.1 EMD62130.1 - 0.00048 19.9 0.1 0.0017 18.2 0.1 1.9 1 0 0 1 1 1 1 AAA lid domain Mg_chelatase_C PF13335.6 EMD62130.1 - 0.019 15.6 0.6 0.085 13.5 0.4 2.2 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI C-terminal AAA_3 PF07726.11 EMD62130.1 - 0.026 14.4 0.0 0.086 12.7 0.0 1.9 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EMD62130.1 - 0.13 12.0 0.0 0.83 9.3 0.0 2.1 2 0 0 2 2 2 0 Sigma-54 interaction domain FtsX_ECD PF18075.1 EMD62130.1 - 0.26 11.9 2.3 2.2 9.0 0.3 2.7 2 0 0 2 2 2 0 FtsX extracellular domain AAA PF00004.29 EMD62131.1 - 2.4e-53 180.1 0.0 2.8e-43 147.5 0.0 2.8 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) PEX-1N PF09262.11 EMD62131.1 - 2.9e-28 98.1 1.5 2.9e-28 98.1 1.5 1.9 2 0 0 2 2 1 1 Peroxisome biogenesis factor 1, N-terminal AAA_lid_3 PF17862.1 EMD62131.1 - 2.6e-15 55.9 0.0 5.5e-10 38.9 0.0 2.6 2 0 0 2 2 2 2 AAA+ lid domain AAA_16 PF13191.6 EMD62131.1 - 1.1e-07 32.4 5.6 0.049 14.0 0.1 4.5 3 2 2 5 5 4 2 AAA ATPase domain AAA_2 PF07724.14 EMD62131.1 - 7.1e-07 29.5 0.0 0.06 13.5 0.0 3.0 3 0 0 3 3 3 2 AAA domain (Cdc48 subfamily) AAA_7 PF12775.7 EMD62131.1 - 1.1e-05 25.1 0.0 0.00072 19.1 0.0 2.5 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_22 PF13401.6 EMD62131.1 - 2e-05 24.9 1.1 0.13 12.5 0.1 3.9 2 2 1 3 3 3 2 AAA domain TsaE PF02367.17 EMD62131.1 - 3.9e-05 23.7 0.0 0.094 12.7 0.0 2.5 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE RuvB_N PF05496.12 EMD62131.1 - 0.00014 21.6 0.0 0.014 15.1 0.0 2.5 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain NACHT PF05729.12 EMD62131.1 - 0.00014 21.8 0.7 0.28 11.1 0.0 3.8 3 1 0 3 3 3 1 NACHT domain AAA_5 PF07728.14 EMD62131.1 - 0.00016 21.7 0.1 0.76 9.8 0.0 3.0 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 EMD62131.1 - 0.00044 20.8 0.1 2.5 8.6 0.0 3.3 3 0 0 3 3 3 2 AAA domain Sigma54_activ_2 PF14532.6 EMD62131.1 - 0.00053 20.1 0.0 0.038 14.1 0.0 2.9 3 0 0 3 3 3 1 Sigma-54 interaction domain AAA_33 PF13671.6 EMD62131.1 - 0.00067 19.8 0.0 0.23 11.6 0.0 2.8 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 EMD62131.1 - 0.0018 17.6 0.0 0.59 9.4 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin IstB_IS21 PF01695.17 EMD62131.1 - 0.002 17.9 0.1 1.6 8.4 0.0 2.3 2 0 0 2 2 2 2 IstB-like ATP binding protein Sigma54_activat PF00158.26 EMD62131.1 - 0.0054 16.4 0.0 0.74 9.5 0.0 3.1 3 1 0 4 4 4 1 Sigma-54 interaction domain RNA_helicase PF00910.22 EMD62131.1 - 0.0084 16.5 0.0 5.3 7.5 0.0 2.7 2 0 0 2 2 2 1 RNA helicase AAA_17 PF13207.6 EMD62131.1 - 0.021 15.3 1.1 2.4 8.6 0.1 3.5 3 0 0 3 3 3 0 AAA domain ABC_tran PF00005.27 EMD62131.1 - 0.04 14.4 0.0 18 5.9 0.0 2.9 2 0 0 2 2 2 0 ABC transporter Mg_chelatase PF01078.21 EMD62131.1 - 0.045 13.1 0.2 0.77 9.1 0.1 2.6 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_14 PF13173.6 EMD62131.1 - 0.051 13.6 0.0 4.4 7.3 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 EMD62131.1 - 0.078 13.2 0.1 20 5.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain Viral_helicase1 PF01443.18 EMD62131.1 - 0.13 12.0 0.1 3.1 7.5 0.0 2.9 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase AAA_25 PF13481.6 EMD62131.1 - 0.15 11.7 6.0 1.5 8.4 0.1 3.7 3 2 2 5 5 5 0 AAA domain TIP49 PF06068.13 EMD62131.1 - 0.17 11.0 0.0 1.2 8.3 0.0 2.0 2 0 0 2 2 2 0 TIP49 P-loop domain AAA_10 PF12846.7 EMD62131.1 - 0.21 10.5 0.0 0.39 9.6 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain PEX-2N PF09263.10 EMD62131.1 - 0.35 11.2 3.6 4.6 7.6 1.1 3.5 2 1 0 2 2 2 0 Peroxisome biogenesis factor 1, N-terminal MPC PF03650.13 EMD62132.1 - 1.2e-34 118.7 0.0 1.5e-34 118.4 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers LSM PF01423.22 EMD62133.1 - 2.1e-18 65.7 0.1 2.7e-18 65.4 0.1 1.1 1 0 0 1 1 1 1 LSM domain Ribosomal_L5_C PF00673.21 EMD62134.1 - 7.2e-23 80.6 0.0 1.1e-22 80.1 0.0 1.3 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 EMD62134.1 - 2.6e-20 72.5 0.0 7.5e-20 71.0 0.0 1.7 2 0 0 2 2 2 1 Ribosomal protein L5 ketoacyl-synt PF00109.26 EMD62135.1 - 4.8e-64 216.4 0.0 8.6e-64 215.5 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.10 EMD62135.1 - 8.1e-60 201.8 0.0 1.8e-59 200.7 0.0 1.6 1 0 0 1 1 1 1 KR domain PS-DH PF14765.6 EMD62135.1 - 2.2e-59 201.1 0.1 4.1e-59 200.2 0.1 1.5 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 EMD62135.1 - 3.7e-47 161.4 0.1 1.8e-46 159.1 0.1 2.1 1 1 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EMD62135.1 - 7.4e-38 129.2 0.0 1.8e-37 127.9 0.0 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Methyltransf_12 PF08242.12 EMD62135.1 - 1.1e-19 71.0 0.0 2.9e-19 69.7 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EMD62135.1 - 5.1e-17 62.2 0.0 1.1e-16 61.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain ADH_zinc_N PF00107.26 EMD62135.1 - 6.6e-16 58.5 0.0 6.7e-15 55.2 0.0 2.5 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EMD62135.1 - 2.1e-15 58.0 0.0 2.7e-12 47.9 0.0 3.6 3 0 0 3 3 3 1 Zinc-binding dehydrogenase KAsynt_C_assoc PF16197.5 EMD62135.1 - 1.8e-14 54.1 0.1 1.7e-12 47.7 0.0 2.8 2 0 0 2 2 2 1 Ketoacyl-synthetase C-terminal extension Methyltransf_25 PF13649.6 EMD62135.1 - 2.5e-12 47.3 0.1 1.2e-11 45.2 0.0 2.3 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMD62135.1 - 7.4e-12 45.8 0.0 2.8e-11 43.9 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain adh_short PF00106.25 EMD62135.1 - 1.4e-09 37.7 0.3 4.2e-08 32.9 0.0 2.8 3 0 0 3 3 3 1 short chain dehydrogenase Methyltransf_31 PF13847.6 EMD62135.1 - 1.6e-09 37.7 0.0 4.2e-09 36.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain ADH_N PF08240.12 EMD62135.1 - 1.3e-06 28.2 0.4 3.3e-06 26.9 0.4 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain PP-binding PF00550.25 EMD62135.1 - 2.5e-06 27.7 0.6 9.4e-06 25.9 0.1 2.4 3 0 0 3 3 1 1 Phosphopantetheine attachment site Ubie_methyltran PF01209.18 EMD62135.1 - 1e-05 25.0 0.0 2.4e-05 23.8 0.0 1.6 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Thiolase_N PF00108.23 EMD62135.1 - 2.5e-05 23.8 0.1 0.00027 20.4 0.0 2.3 3 0 0 3 3 2 1 Thiolase, N-terminal domain adh_short_C2 PF13561.6 EMD62135.1 - 0.00048 19.7 0.0 0.0012 18.5 0.0 1.6 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Methyltransf_16 PF10294.9 EMD62135.1 - 0.0027 17.5 0.1 0.017 14.9 0.0 2.2 1 1 1 2 2 2 1 Lysine methyltransferase DREV PF05219.12 EMD62135.1 - 0.045 12.9 0.0 0.081 12.0 0.0 1.3 1 0 0 1 1 1 0 DREV methyltransferase Pyr_redox PF00070.27 EMD62135.1 - 0.17 12.5 0.1 0.84 10.2 0.0 2.2 2 0 0 2 2 1 0 Pyridine nucleotide-disulphide oxidoreductase p450 PF00067.22 EMD62136.1 - 2.8e-22 79.1 0.1 4.3e-18 65.3 0.0 2.1 2 0 0 2 2 2 2 Cytochrome P450 Alpha-amylase PF00128.24 EMD62138.1 - 6.5e-92 308.7 0.0 9.7e-92 308.1 0.0 1.2 1 0 0 1 1 1 1 Alpha amylase, catalytic domain Malt_amylase_C PF16657.5 EMD62138.1 - 0.00043 20.3 0.0 0.00099 19.2 0.0 1.6 1 0 0 1 1 1 1 Maltogenic Amylase, C-terminal domain hDGE_amylase PF14701.6 EMD62138.1 - 0.096 11.8 0.2 0.15 11.2 0.2 1.1 1 0 0 1 1 1 0 Glycogen debranching enzyme, glucanotransferase domain DUF2202 PF09968.9 EMD62138.1 - 0.11 12.3 0.1 1.9 8.3 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized protein domain (DUF2202) FSH1 PF03959.13 EMD62139.1 - 1.2e-08 34.8 0.0 1.6e-08 34.5 0.0 1.2 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Fasciclin PF02469.22 EMD62141.1 - 3.8e-20 72.4 0.0 8e-15 55.2 0.0 3.0 2 1 0 2 2 2 2 Fasciclin domain Aminotran_3 PF00202.21 EMD62142.1 - 1e-39 136.4 0.6 6.3e-17 61.3 0.0 3.0 2 1 1 3 3 3 3 Aminotransferase class-III THB PF18362.1 EMD62142.1 - 0.13 11.9 0.6 5.4 6.7 0.1 2.8 3 0 0 3 3 3 0 Tri-helix bundle domain ADH_N PF08240.12 EMD62143.1 - 1.8e-27 95.4 4.4 4.1e-27 94.2 4.4 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EMD62143.1 - 4e-09 36.5 0.0 4.1e-05 23.6 0.0 2.3 2 0 0 2 2 2 2 Zinc-binding dehydrogenase ADH_N_assoc PF13823.6 EMD62143.1 - 7.4e-08 32.2 0.4 1.3e-07 31.4 0.4 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-associated PALP PF00291.25 EMD62146.1 - 7.8e-64 215.9 0.5 1e-63 215.5 0.5 1.2 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme DUF3367 PF11847.8 EMD62146.1 - 0.056 11.3 0.2 0.15 9.9 0.1 1.6 2 0 0 2 2 2 0 Alpha-(1->3)-arabinofuranosyltransferase TIR_3 PF18567.1 EMD62146.1 - 0.11 12.5 0.0 0.22 11.5 0.0 1.5 1 0 0 1 1 1 0 Toll/interleukin-1 receptor domain PPTA PF01239.22 EMD62147.1 - 2.1e-41 138.5 18.6 4.4e-10 39.0 0.4 6.4 6 0 0 6 6 6 6 Protein prenyltransferase alpha subunit repeat DUF4219 PF13961.6 EMD62147.1 - 0.11 12.1 7.8 2.8 7.7 0.2 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4219) Ceramidase PF05875.12 EMD62148.1 - 0.055 12.9 0.4 0.067 12.6 0.4 1.1 1 0 0 1 1 1 0 Ceramidase DUF5518 PF17647.1 EMD62148.1 - 0.056 13.6 0.1 0.07 13.3 0.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5518) zf-C3HC4_2 PF13923.6 EMD62149.1 - 1.4e-10 40.8 7.6 2.3e-10 40.1 7.6 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMD62149.1 - 2e-09 37.2 8.5 3.4e-09 36.4 8.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EMD62149.1 - 2.3e-09 37.0 4.8 3.6e-09 36.3 4.8 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) HIRAN PF08797.11 EMD62149.1 - 1.9e-08 34.1 0.0 3.9e-08 33.1 0.0 1.5 1 0 0 1 1 1 1 HIRAN domain zf-RING_2 PF13639.6 EMD62149.1 - 2.1e-08 34.3 7.3 3.3e-08 33.7 7.3 1.3 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 EMD62149.1 - 5.3e-06 26.3 6.4 8.9e-06 25.6 6.4 1.3 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EMD62149.1 - 7.7e-06 25.7 5.2 1.5e-05 24.8 5.2 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 EMD62149.1 - 2.6e-05 24.2 4.8 2.6e-05 24.2 4.8 2.0 1 1 1 2 2 2 1 RING-type zinc-finger zf-rbx1 PF12678.7 EMD62149.1 - 0.00012 22.2 3.2 0.00023 21.4 3.2 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-P11 PF03854.14 EMD62149.1 - 0.00016 21.3 5.0 0.00042 19.9 5.0 1.7 1 0 0 1 1 1 1 P-11 zinc finger zf-RING_4 PF14570.6 EMD62149.1 - 0.00064 19.5 3.4 0.00064 19.5 3.4 1.6 1 1 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.6 EMD62149.1 - 0.0032 17.6 6.8 0.0059 16.7 6.8 1.4 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Rad50_zn_hook PF04423.14 EMD62149.1 - 0.035 13.9 0.1 0.091 12.6 0.1 1.7 1 0 0 1 1 1 0 Rad50 zinc hook motif DUF1272 PF06906.11 EMD62149.1 - 0.062 13.4 2.5 0.11 12.6 2.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) IceA2 PF05862.11 EMD62149.1 - 0.074 13.0 0.3 0.13 12.2 0.2 1.4 1 1 0 1 1 1 0 Helicobacter pylori IceA2 protein zf-RING_6 PF14835.6 EMD62149.1 - 0.15 11.9 2.3 0.26 11.2 2.3 1.3 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-C3HC4_5 PF17121.5 EMD62149.1 - 0.65 9.9 4.4 2 8.3 4.4 1.8 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DEADboxA PF12343.8 EMD62150.1 - 0.00079 19.9 5.1 0.00079 19.9 5.1 2.5 2 1 0 2 2 2 1 Cold shock protein DEAD box A zf-C2H2 PF00096.26 EMD62151.1 - 1.1e-12 47.6 14.2 6.1e-07 29.5 1.6 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMD62151.1 - 2.1e-08 34.3 11.5 0.00037 21.1 0.6 2.9 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EMD62151.1 - 3.7e-06 27.1 5.1 0.011 16.0 1.1 2.5 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.6 EMD62151.1 - 2.6e-05 24.4 14.9 8.7e-05 22.8 6.0 3.5 3 0 0 3 3 3 1 Zinc-finger double domain zf-met PF12874.7 EMD62151.1 - 0.00026 21.3 8.3 0.0058 17.0 0.3 2.9 3 0 0 3 3 2 2 Zinc-finger of C2H2 type zf_C2H2_ZHX PF18387.1 EMD62151.1 - 0.0044 16.6 3.3 1.6 8.4 0.2 2.5 1 1 1 2 2 2 2 Zinc-fingers and homeoboxes C2H2 finger domain zf-C2H2_6 PF13912.6 EMD62151.1 - 0.011 15.7 11.8 0.11 12.5 1.3 2.6 2 1 0 2 2 2 0 C2H2-type zinc finger zf-LYAR PF08790.11 EMD62151.1 - 0.013 15.4 8.7 0.1 12.6 0.7 3.4 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger zf-C2H2_3rep PF18868.1 EMD62151.1 - 0.041 14.6 2.7 0.74 10.5 0.4 2.5 1 1 1 2 2 2 0 Zinc finger C2H2-type, 3 repeats zf-UBR PF02207.20 EMD62151.1 - 0.12 12.5 1.7 0.27 11.4 1.7 1.5 1 0 0 1 1 1 0 Putative zinc finger in N-recognin (UBR box) zf-C2H2_11 PF16622.5 EMD62151.1 - 0.18 11.6 9.3 1.3 8.8 0.1 2.7 2 0 0 2 2 2 0 zinc-finger C2H2-type LIM PF00412.22 EMD62151.1 - 0.18 12.0 2.9 0.53 10.6 3.0 1.8 1 1 0 1 1 1 0 LIM domain zf-trcl PF13451.6 EMD62151.1 - 0.54 10.2 3.3 1.3 9.0 0.5 2.3 2 0 0 2 2 2 0 Probable zinc-ribbon domain zf-C2HE PF16278.5 EMD62151.1 - 1.5 9.4 7.0 1.6e+02 2.9 7.0 2.5 1 1 0 1 1 1 0 C2HE / C2H2 / C2HC zinc-binding finger Zn-ribbon_8 PF09723.10 EMD62151.1 - 3.5 7.8 7.3 4.9 7.4 0.5 3.5 3 1 1 4 4 4 0 Zinc ribbon domain zf-BED PF02892.15 EMD62151.1 - 6.2 6.9 7.4 3.6 7.7 3.2 2.4 1 1 1 2 2 2 0 BED zinc finger Diphthami_syn_2 PF01902.17 EMD62152.1 - 4.5e-22 78.6 0.0 7.5e-19 68.1 0.0 2.2 1 1 0 1 1 1 1 Diphthamide synthase Ribonuc_L-PSP PF01042.21 EMD62152.1 - 4.6e-13 49.2 0.0 7.1e-06 26.0 0.0 4.2 3 1 1 4 4 4 3 Endoribonuclease L-PSP BBP2_2 PF10082.9 EMD62152.1 - 0.064 12.1 0.2 0.1 11.4 0.2 1.3 1 0 0 1 1 1 0 Putative beta-barrel porin 2 MDM31_MDM32 PF08118.11 EMD62153.1 - 4e-246 817.8 0.3 5e-246 817.4 0.3 1.1 1 0 0 1 1 1 1 Yeast mitochondrial distribution and morphology (MDM) proteins KH_8 PF17903.1 EMD62154.1 - 2.6e-05 24.2 0.0 4.9e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 Krr1 KH1 domain KH_1 PF00013.29 EMD62154.1 - 0.014 15.2 1.0 0.027 14.3 1.0 1.4 1 0 0 1 1 1 0 KH domain ABC2_membrane PF01061.24 EMD62155.1 - 7.8e-81 270.5 61.7 8e-43 146.3 15.7 2.7 3 0 0 3 3 3 2 ABC-2 type transporter ABC_tran PF00005.27 EMD62155.1 - 2e-37 128.8 0.1 1.8e-18 67.4 0.0 2.6 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.12 EMD62155.1 - 2.5e-31 107.4 2.6 6.9e-26 90.0 0.0 2.9 2 0 0 2 2 2 2 CDR ABC transporter ABC_trans_N PF14510.6 EMD62155.1 - 1.4e-17 64.0 1.1 1.4e-17 64.0 1.1 2.3 2 0 0 2 2 2 1 ABC-transporter N-terminal AAA_21 PF13304.6 EMD62155.1 - 1.3e-06 28.5 0.2 0.021 14.6 0.0 2.8 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system ABC2_membrane_3 PF12698.7 EMD62155.1 - 2.5e-06 26.9 29.8 0.0022 17.1 10.8 2.7 2 0 0 2 2 2 2 ABC-2 family transporter protein AAA_16 PF13191.6 EMD62155.1 - 2.5e-06 28.0 0.1 0.00081 19.8 0.1 2.6 2 0 0 2 2 2 1 AAA ATPase domain RsgA_GTPase PF03193.16 EMD62155.1 - 4.5e-06 26.7 0.6 0.00016 21.6 0.0 2.6 3 0 0 3 3 2 1 RsgA GTPase MMR_HSR1 PF01926.23 EMD62155.1 - 5e-05 23.3 0.4 0.0062 16.6 0.2 2.9 3 0 0 3 3 2 1 50S ribosome-binding GTPase AAA_29 PF13555.6 EMD62155.1 - 9.1e-05 22.1 0.5 0.057 13.2 0.1 2.8 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_18 PF13238.6 EMD62155.1 - 0.00024 21.7 0.1 0.013 16.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EMD62155.1 - 0.00028 21.2 0.0 0.16 12.3 0.0 2.9 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EMD62155.1 - 0.0014 18.8 0.0 0.063 13.4 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.6 EMD62155.1 - 0.0015 18.8 0.1 0.0043 17.3 0.0 1.9 2 0 0 2 2 1 1 AAA domain cobW PF02492.19 EMD62155.1 - 0.0017 18.0 0.0 0.13 11.9 0.0 2.6 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain SMC_N PF02463.19 EMD62155.1 - 0.0029 17.1 1.8 0.064 12.7 0.0 2.9 3 1 0 3 3 3 1 RecF/RecN/SMC N terminal domain FtsK_SpoIIIE PF01580.18 EMD62155.1 - 0.0053 16.2 0.3 1.5 8.1 0.0 2.7 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_25 PF13481.6 EMD62155.1 - 0.016 14.8 0.1 0.26 10.8 0.1 2.6 3 0 0 3 3 3 0 AAA domain Ploopntkinase3 PF18751.1 EMD62155.1 - 0.024 14.6 0.0 0.95 9.3 0.0 2.4 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 NACHT PF05729.12 EMD62155.1 - 0.026 14.5 0.1 1.6 8.6 0.1 2.4 2 0 0 2 2 2 0 NACHT domain Dynamin_N PF00350.23 EMD62155.1 - 0.029 14.4 0.3 0.09 12.8 0.3 1.9 1 0 0 1 1 1 0 Dynamin family Septin PF00735.18 EMD62155.1 - 0.049 12.9 0.1 0.28 10.4 0.1 2.0 2 0 0 2 2 2 0 Septin NB-ARC PF00931.22 EMD62155.1 - 0.062 12.5 0.5 2.9 7.0 0.1 2.7 3 0 0 3 3 3 0 NB-ARC domain AAA_30 PF13604.6 EMD62155.1 - 0.092 12.5 2.6 4.5 6.9 0.4 2.7 3 0 0 3 3 2 0 AAA domain AAA_24 PF13479.6 EMD62155.1 - 0.1 12.3 0.1 1.1 9.0 0.1 2.4 3 0 0 3 3 2 0 AAA domain Zeta_toxin PF06414.12 EMD62155.1 - 0.11 11.8 0.5 0.37 10.0 0.2 1.9 2 0 0 2 2 2 0 Zeta toxin NAD_Gly3P_dh_C PF07479.14 EMD62156.1 - 2.9e-46 157.3 0.1 4.9e-46 156.6 0.1 1.4 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus NAD_Gly3P_dh_N PF01210.23 EMD62156.1 - 9.1e-46 155.7 0.0 3.2e-45 153.9 0.0 1.7 2 0 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_binding_4 PF07993.12 EMD62158.1 - 5.4e-45 153.6 0.0 8.3e-45 153.0 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein AMP-binding PF00501.28 EMD62158.1 - 1.7e-23 82.9 0.0 2.9e-23 82.1 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme Epimerase PF01370.21 EMD62158.1 - 4e-09 36.3 0.0 7.3e-09 35.4 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family PP-binding PF00550.25 EMD62158.1 - 5.7e-09 36.2 0.0 2.7e-08 34.0 0.0 2.1 2 0 0 2 2 2 1 Phosphopantetheine attachment site 3Beta_HSD PF01073.19 EMD62158.1 - 0.00015 20.9 0.0 0.0012 18.0 0.0 2.0 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Semialdhyde_dh PF01118.24 EMD62158.1 - 0.017 15.6 0.0 0.037 14.5 0.0 1.6 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain GH3 PF03321.13 EMD62158.1 - 0.031 13.2 0.0 0.05 12.5 0.0 1.2 1 0 0 1 1 1 0 GH3 auxin-responsive promoter KR PF08659.10 EMD62158.1 - 0.1 12.5 0.2 0.78 9.6 0.2 2.2 1 1 0 1 1 1 0 KR domain PCDO_beta_N PF12391.8 EMD62159.1 - 0.08 12.6 0.6 0.08 12.6 0.6 1.9 2 0 0 2 2 2 0 Protocatechuate 3,4-dioxygenase beta subunit N terminal MFS_1 PF07690.16 EMD62160.1 - 1.9e-38 132.3 47.6 1.9e-38 132.3 47.6 1.7 2 0 0 2 2 2 1 Major Facilitator Superfamily C2 PF00168.30 EMD62161.1 - 1.9e-09 37.7 0.0 4.4e-09 36.6 0.0 1.6 1 0 0 1 1 1 1 C2 domain DUF3530 PF12048.8 EMD62161.1 - 0.24 10.8 0.0 0.24 10.8 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3530) MFS_1 PF07690.16 EMD62162.1 - 3.4e-47 161.1 38.7 3.4e-47 161.1 38.7 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EMD62162.1 - 6e-12 45.2 3.1 6e-12 45.2 3.1 2.3 2 0 0 2 2 2 1 Sugar (and other) transporter Epimerase PF01370.21 EMD62163.1 - 2.5e-23 82.8 0.0 4.5e-23 82.0 0.0 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EMD62163.1 - 5.5e-13 49.0 0.2 4.6e-12 46.0 0.0 2.3 2 1 0 2 2 2 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 EMD62163.1 - 7.9e-11 41.5 0.0 1.1e-10 41.0 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 EMD62163.1 - 4.8e-08 32.5 0.0 7.3e-08 31.8 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 EMD62163.1 - 3.2e-05 23.2 0.0 0.00075 18.7 0.0 2.1 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 EMD62163.1 - 3.6e-05 23.1 0.1 0.00021 20.5 0.0 1.9 2 0 0 2 2 2 1 Male sterility protein NAD_binding_10 PF13460.6 EMD62163.1 - 0.0002 21.3 0.0 0.00058 19.8 0.0 1.8 1 1 0 1 1 1 1 NAD(P)H-binding Proteasome PF00227.26 EMD62164.1 - 1.3e-27 96.6 0.0 1.5e-27 96.3 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit HCNGP PF07818.13 EMD62165.1 - 1.4e-27 96.1 0.9 2.5e-27 95.4 0.9 1.4 1 0 0 1 1 1 1 HCNGP-like protein PRP38_assoc PF12871.7 EMD62165.1 - 0.11 13.1 15.0 0.2 12.3 15.0 1.4 1 0 0 1 1 1 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term Corona_nucleoca PF00937.18 EMD62165.1 - 0.12 11.4 4.7 0.15 11.1 4.7 1.2 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein FAD_binding_2 PF00890.24 EMD62166.1 - 2.8e-27 95.9 0.0 4.5e-25 88.6 0.0 2.0 1 1 1 2 2 2 2 FAD binding domain FAD_oxidored PF12831.7 EMD62166.1 - 2.9e-07 30.2 0.1 4e-06 26.5 0.0 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.17 EMD62166.1 - 0.00016 21.0 0.2 0.0005 19.4 0.0 1.8 2 0 0 2 2 2 1 Thi4 family Pyr_redox_2 PF07992.14 EMD62166.1 - 0.0033 16.7 0.1 0.0061 15.8 0.0 1.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EMD62166.1 - 0.025 14.8 0.1 0.057 13.7 0.1 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 EMD62166.1 - 0.048 12.4 0.0 0.064 11.9 0.0 1.2 1 0 0 1 1 1 0 HI0933-like protein DUF3659 PF12396.8 EMD62166.1 - 0.12 12.3 0.2 18 5.3 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3659) Pyr_redox_3 PF13738.6 EMD62166.1 - 0.19 11.0 0.0 0.26 10.5 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase PATR PF12951.7 EMD62166.1 - 0.84 9.8 3.7 1.9 8.6 3.7 1.5 1 0 0 1 1 1 0 Passenger-associated-transport-repeat Proteasome PF00227.26 EMD62167.1 - 1.5e-31 109.3 0.2 4.1e-31 107.9 0.2 1.8 1 1 0 1 1 1 1 Proteasome subunit Enolase_C PF00113.22 EMD62168.1 - 1.1e-155 517.2 0.1 1.5e-155 516.8 0.1 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.16 EMD62168.1 - 5.6e-58 194.8 0.5 1.1e-57 193.9 0.5 1.5 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.6 EMD62168.1 - 4.9e-07 29.5 0.0 9e-07 28.7 0.0 1.4 1 0 0 1 1 1 1 Enolase C-terminal domain-like MAAL_C PF07476.11 EMD62168.1 - 0.012 14.8 1.1 0.32 10.1 0.1 2.8 3 0 0 3 3 3 0 Methylaspartate ammonia-lyase C-terminus EF-hand_7 PF13499.6 EMD62168.1 - 0.13 12.7 0.4 0.57 10.7 0.1 2.2 2 0 0 2 2 2 0 EF-hand domain pair Proteasome PF00227.26 EMD62169.1 - 4.2e-37 127.5 0.0 4.8e-37 127.3 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit DHQ_synthase PF01761.20 EMD62170.1 - 6.9e-54 182.8 0.0 1e-53 182.2 0.0 1.2 1 0 0 1 1 1 1 3-dehydroquinate synthase Fe-ADH_2 PF13685.6 EMD62170.1 - 3.4e-09 36.8 0.0 5.1e-09 36.2 0.0 1.2 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Methyltransf_3 PF01596.17 EMD62171.1 - 1.4e-12 47.3 0.0 1.9e-12 46.8 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.6 EMD62171.1 - 6.7e-10 39.9 0.0 1.1e-09 39.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CmcI PF04989.12 EMD62171.1 - 0.041 13.6 0.0 0.06 13.0 0.0 1.4 1 1 0 1 1 1 0 Cephalosporin hydroxylase Kinesin PF00225.23 EMD62175.1 - 1.7e-93 313.2 0.0 4.8e-93 311.7 0.0 1.7 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 EMD62175.1 - 1.1e-22 80.6 0.0 2.4e-22 79.5 0.0 1.6 1 0 0 1 1 1 1 Microtubule binding DUF2031 PF09592.10 EMD62175.1 - 0.0066 16.0 4.8 0.012 15.1 4.8 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2031) Anti-adapt_IraP PF10796.9 EMD62175.1 - 0.023 15.3 0.1 0.062 13.9 0.1 1.7 1 0 0 1 1 1 0 Sigma-S stabilisation anti-adaptor protein Pox_A_type_inc PF04508.12 EMD62175.1 - 0.025 14.4 0.4 0.025 14.4 0.4 3.1 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat Mei5 PF10376.9 EMD62175.1 - 0.063 13.1 7.1 1.6 8.6 0.2 2.3 2 0 0 2 2 2 0 Double-strand recombination repair protein DUF641 PF04859.12 EMD62175.1 - 1.2 9.5 6.4 29 5.0 0.0 3.4 3 1 0 3 3 3 0 Plant protein of unknown function (DUF641) CdhD PF03599.16 EMD62176.1 - 0.055 12.2 0.0 0.072 11.8 0.0 1.1 1 0 0 1 1 1 0 CO dehydrogenase/acetyl-CoA synthase delta subunit WD40 PF00400.32 EMD62178.1 - 1.1e-53 177.9 23.5 4.8e-06 27.2 0.0 12.2 12 1 0 12 12 12 10 WD domain, G-beta repeat Utp13 PF08625.11 EMD62178.1 - 8e-50 168.4 0.1 1.3e-49 167.8 0.1 1.3 1 0 0 1 1 1 1 Utp13 specific WD40 associated domain ANAPC4_WD40 PF12894.7 EMD62178.1 - 9.4e-20 70.7 1.7 0.014 15.7 0.0 9.0 5 3 3 8 8 8 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EMD62178.1 - 0.00013 21.1 0.0 0.66 8.9 0.0 3.8 4 1 0 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 EMD62178.1 - 0.0003 19.6 0.7 3.2 6.3 0.0 4.4 3 2 1 4 4 4 2 Nucleoporin Nup120/160 PALB2_WD40 PF16756.5 EMD62178.1 - 0.035 13.0 0.4 1.7 7.5 0.1 2.3 2 0 0 2 2 2 0 Partner and localizer of BRCA2 WD40 domain Nucleoporin_N PF08801.11 EMD62178.1 - 0.036 12.8 1.9 14 4.3 0.1 4.7 4 2 1 5 5 5 0 Nup133 N terminal like UCH PF00443.29 EMD62179.1 - 2.1e-26 93.0 0.0 3e-26 92.5 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 EMD62179.1 - 8e-11 42.1 0.2 1.8e-10 41.0 0.2 1.6 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.6 EMD62179.1 - 0.0077 15.9 0.1 0.22 11.0 0.1 2.3 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Cpn60_TCP1 PF00118.24 EMD62180.1 - 1e-142 476.3 12.5 1.1e-142 476.1 12.5 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family CRM1_repeat PF18777.1 EMD62180.1 - 0.099 12.2 0.0 0.2 11.2 0.0 1.4 1 0 0 1 1 1 0 Chromosome region maintenance or exportin repeat Ribonuc_2-5A PF06479.12 EMD62181.1 - 4e-44 149.9 0.1 7.7e-44 148.9 0.1 1.5 1 0 0 1 1 1 1 Ribonuclease 2-5A Pkinase PF00069.25 EMD62181.1 - 5.8e-42 143.9 0.0 1.9e-41 142.2 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD62181.1 - 2.4e-20 72.9 0.0 4.5e-20 72.0 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EMD62181.1 - 0.00097 18.0 0.0 0.0022 16.8 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase PQQ PF01011.21 EMD62181.1 - 0.0029 17.5 0.4 0.023 14.6 0.0 2.4 2 0 0 2 2 2 1 PQQ enzyme repeat APH PF01636.23 EMD62181.1 - 0.015 15.2 0.2 0.072 13.0 0.2 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.14 EMD62181.1 - 0.064 12.6 0.1 0.12 11.7 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Polyketide_cyc PF03364.20 EMD62182.1 - 7.3e-17 61.8 0.1 2e-16 60.4 0.1 1.7 1 1 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc2 PF10604.9 EMD62182.1 - 4.1e-05 23.9 1.1 0.00034 20.9 1.1 2.0 1 1 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport DUF5304 PF17230.2 EMD62182.1 - 0.085 13.1 0.2 0.17 12.1 0.2 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5304) Methyltransf_12 PF08242.12 EMD62183.1 - 4.8e-14 52.9 0.0 1.3e-13 51.5 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMD62183.1 - 1e-12 48.6 0.0 2.3e-12 47.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EMD62183.1 - 9.3e-12 45.1 0.0 1.9e-11 44.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMD62183.1 - 1e-10 42.1 0.0 2.3e-10 41.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_24 PF13578.6 EMD62183.1 - 2.8e-05 25.1 0.0 6e-05 24.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMD62183.1 - 2.9e-05 23.9 0.0 5.6e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EMD62183.1 - 0.00047 19.6 0.0 0.001 18.4 0.0 1.5 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family NNMT_PNMT_TEMT PF01234.17 EMD62183.1 - 0.012 14.8 0.0 0.57 9.3 0.0 2.5 2 1 0 2 2 2 0 NNMT/PNMT/TEMT family MTS PF05175.14 EMD62183.1 - 0.063 12.8 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain DUF4946 PF16304.5 EMD62183.1 - 0.085 12.6 1.9 0.16 11.6 1.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4946) AAA_22 PF13401.6 EMD62184.1 - 5.9e-11 42.8 0.1 3.6e-10 40.3 0.0 2.2 2 1 1 3 3 3 1 AAA domain AAA PF00004.29 EMD62184.1 - 1.6e-10 41.5 0.0 4.9e-10 39.9 0.0 1.9 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EMD62184.1 - 4.8e-10 40.1 1.0 7e-09 36.3 0.2 2.7 2 1 0 2 2 2 1 AAA ATPase domain Cdc6_C PF09079.11 EMD62184.1 - 1.2e-08 34.8 0.0 3.3e-08 33.4 0.0 1.7 1 0 0 1 1 1 1 CDC6, C terminal winged helix domain AAA_lid_10 PF17872.1 EMD62184.1 - 6.2e-06 26.3 0.1 1.5e-05 25.0 0.1 1.6 1 0 0 1 1 1 1 AAA lid domain AAA_19 PF13245.6 EMD62184.1 - 0.00036 20.9 0.0 0.00096 19.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain TniB PF05621.11 EMD62184.1 - 0.0005 19.5 0.0 0.0015 18.0 0.0 1.7 2 0 0 2 2 2 1 Bacterial TniB protein NTPase_1 PF03266.15 EMD62184.1 - 0.002 18.1 0.1 0.026 14.4 0.1 2.2 1 1 1 2 2 2 1 NTPase AAA_7 PF12775.7 EMD62184.1 - 0.0029 17.2 0.0 0.0054 16.3 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region RNA_helicase PF00910.22 EMD62184.1 - 0.0058 17.0 0.0 0.011 16.1 0.0 1.5 1 0 0 1 1 1 1 RNA helicase AAA_5 PF07728.14 EMD62184.1 - 0.0069 16.4 0.0 0.016 15.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Roc PF08477.13 EMD62184.1 - 0.026 14.7 0.0 0.092 13.0 0.0 1.9 1 1 1 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_14 PF13173.6 EMD62184.1 - 0.042 13.9 0.0 0.097 12.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 EMD62184.1 - 0.071 13.0 0.0 0.15 11.9 0.0 1.6 1 0 0 1 1 1 0 NACHT domain RNA12 PF10443.9 EMD62184.1 - 0.076 11.7 0.0 0.13 11.0 0.0 1.3 1 0 0 1 1 1 0 RNA12 protein RuvB_N PF05496.12 EMD62184.1 - 0.097 12.4 0.0 0.24 11.1 0.0 1.6 1 1 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain DUF815 PF05673.13 EMD62184.1 - 0.11 11.6 0.0 0.24 10.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_18 PF13238.6 EMD62184.1 - 0.16 12.5 0.0 0.28 11.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain RFX_DNA_binding PF02257.15 EMD62184.1 - 0.2 12.3 0.0 2.4 8.9 0.0 2.2 2 0 0 2 2 2 0 RFX DNA-binding domain Cu_amine_oxid PF01179.20 EMD62186.1 - 2.2e-118 395.7 3.2 3.1e-118 395.2 3.2 1.2 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain DUF1965 PF09248.10 EMD62186.1 - 2.3e-29 101.0 2.5 4.1e-29 100.2 0.5 2.5 3 0 0 3 3 3 1 Domain of unknown function (DUF1965) Cu_amine_oxidN2 PF02727.16 EMD62186.1 - 0.00069 19.8 0.0 0.0013 18.9 0.0 1.5 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain Sugar_tr PF00083.24 EMD62188.1 - 1.2e-38 133.2 15.0 3.1e-26 92.3 0.8 2.5 2 1 1 3 3 3 2 Sugar (and other) transporter MFS_1 PF07690.16 EMD62188.1 - 7e-22 77.8 13.5 1e-20 74.0 13.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily FA_desaturase PF00487.24 EMD62188.1 - 2.4 8.0 6.4 2.6 7.8 1.3 2.8 2 0 0 2 2 2 0 Fatty acid desaturase Acetyltransf_10 PF13673.7 EMD62189.1 - 1.2e-06 28.4 0.0 2.3e-06 27.5 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EMD62189.1 - 1.6e-06 28.4 0.0 3.7e-06 27.3 0.0 1.6 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EMD62189.1 - 4.7e-06 26.8 0.0 6.6e-06 26.4 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 EMD62189.1 - 0.016 15.2 0.0 0.21 11.6 0.0 2.3 1 1 0 1 1 1 0 FR47-like protein Acetyltransf_16 PF05301.11 EMD62189.1 - 0.055 13.2 0.0 0.08 12.7 0.0 1.3 1 0 0 1 1 1 0 GNAT acetyltransferase, Mec-17 Glyco_hydro_72 PF03198.14 EMD62190.1 - 1.8e-56 191.7 0.1 5.7e-36 124.3 0.0 2.1 1 1 1 2 2 2 2 Glucanosyltransferase DUF4350 PF14258.6 EMD62190.1 - 0.031 14.7 0.0 0.1 13.0 0.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4350) SAPIS-gp6 PF16722.5 EMD62190.1 - 0.25 11.8 0.7 2.6 8.5 0.1 2.3 2 0 0 2 2 2 0 Pathogenicity island protein gp6 in Staphylococcus Cutinase PF01083.22 EMD62191.1 - 7.8e-46 156.3 3.0 9.2e-46 156.0 3.0 1.1 1 0 0 1 1 1 1 Cutinase PE-PPE PF08237.11 EMD62191.1 - 0.016 14.7 0.2 0.023 14.3 0.2 1.3 1 0 0 1 1 1 0 PE-PPE domain Palm_thioest PF02089.15 EMD62191.1 - 0.019 14.8 0.1 0.02 14.7 0.1 1.1 1 0 0 1 1 1 0 Palmitoyl protein thioesterase Abhydrolase_1 PF00561.20 EMD62191.1 - 0.03 14.0 0.1 0.04 13.5 0.1 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold Thioesterase PF00975.20 EMD62191.1 - 0.04 14.0 0.1 0.059 13.5 0.1 1.2 1 0 0 1 1 1 0 Thioesterase domain Hydrolase_4 PF12146.8 EMD62191.1 - 0.075 12.3 0.2 0.075 12.3 0.2 1.5 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Lipase_3 PF01764.25 EMD62191.1 - 0.1 12.4 0.1 0.15 11.9 0.1 1.4 1 1 0 1 1 1 0 Lipase (class 3) DUF2974 PF11187.8 EMD62191.1 - 0.17 11.5 0.1 0.28 10.7 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Abhydrolase_3 PF07859.13 EMD62191.1 - 0.17 11.7 2.1 0.37 10.6 2.0 1.8 1 1 0 1 1 1 0 alpha/beta hydrolase fold Glyco_hydro_43 PF04616.14 EMD62192.1 - 1.7e-17 63.7 4.5 2.4e-17 63.2 3.9 1.4 1 1 0 1 1 1 1 Glycosyl hydrolases family 43 CBM_35 PF16990.5 EMD62192.1 - 0.00078 19.7 0.6 0.0017 18.6 0.6 1.5 1 0 0 1 1 1 1 Carbohydrate binding module (family 35) Glyco_hydro_32N PF00251.20 EMD62192.1 - 0.0068 16.0 0.6 0.13 11.8 0.0 2.3 2 0 0 2 2 2 1 Glycosyl hydrolases family 32 N-terminal domain ParE-like_toxin PF15781.5 EMD62193.1 - 0.046 13.7 3.1 0.56 10.2 0.0 3.0 3 0 0 3 3 3 0 ParE-like toxin of type II bacterial toxin-antitoxin system STI1 PF17830.1 EMD62193.1 - 0.27 11.2 16.1 1.2 9.1 1.0 4.5 4 2 0 4 4 4 0 STI1 domain P2 PF07194.11 EMD62193.1 - 2.5 8.2 6.6 0.44 10.6 0.7 2.8 2 1 1 3 3 3 0 P2 response regulator binding domain Pyr_redox_2 PF07992.14 EMD62194.1 - 3.5e-17 62.6 0.0 5.6e-17 61.9 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 EMD62194.1 - 6.7e-15 54.5 0.0 1.4e-10 40.3 0.0 2.6 2 1 0 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EMD62194.1 - 1.3e-11 44.3 0.1 9e-10 38.3 0.0 3.3 3 1 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EMD62194.1 - 4.7e-11 42.7 1.1 7.3e-09 35.7 0.1 2.6 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EMD62194.1 - 1.4e-07 31.4 0.5 0.00065 19.4 0.2 3.5 4 0 0 4 4 4 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EMD62194.1 - 3.4e-06 27.1 0.7 2.4e-05 24.4 0.1 2.5 2 1 0 2 2 2 1 FAD-NAD(P)-binding Amino_oxidase PF01593.24 EMD62194.1 - 5.4e-06 26.0 0.5 3.2e-05 23.4 0.1 2.5 3 0 0 3 3 3 1 Flavin containing amine oxidoreductase FAD_binding_3 PF01494.19 EMD62194.1 - 1.9e-05 24.1 0.8 1.9e-05 24.1 0.8 1.8 2 0 0 2 2 2 1 FAD binding domain Pyr_redox PF00070.27 EMD62194.1 - 2.2e-05 24.9 1.7 0.049 14.2 0.2 2.8 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EMD62194.1 - 2.8e-05 23.5 2.0 5e-05 22.6 0.1 2.3 3 1 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) HI0933_like PF03486.14 EMD62194.1 - 3.1e-05 22.9 3.2 0.00029 19.7 0.2 2.9 3 0 0 3 3 3 1 HI0933-like protein AlaDh_PNT_C PF01262.21 EMD62194.1 - 4.8e-05 22.8 0.8 0.26 10.5 0.0 2.2 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.22 EMD62194.1 - 0.00057 19.1 3.2 0.25 10.4 1.2 2.3 2 0 0 2 2 2 2 Glucose inhibited division protein A FAD_binding_2 PF00890.24 EMD62194.1 - 0.0027 16.8 0.5 0.0027 16.8 0.5 2.4 2 0 0 2 2 2 1 FAD binding domain Thi4 PF01946.17 EMD62194.1 - 0.0062 15.8 0.1 0.0062 15.8 0.1 1.6 2 0 0 2 2 2 1 Thi4 family FAD_oxidored PF12831.7 EMD62194.1 - 0.032 13.6 7.3 0.054 12.8 0.6 2.3 2 0 0 2 2 2 0 FAD dependent oxidoreductase NAD_binding_7 PF13241.6 EMD62194.1 - 0.036 14.5 0.0 0.1 13.1 0.0 1.7 1 0 0 1 1 1 0 Putative NAD(P)-binding 3HCDH_N PF02737.18 EMD62194.1 - 0.29 11.0 1.7 3.4 7.5 0.2 2.4 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Trp_halogenase PF04820.14 EMD62194.1 - 1.1 8.0 4.1 5.9 5.6 0.5 2.3 2 0 0 2 2 2 0 Tryptophan halogenase Complex1_LYR PF05347.15 EMD62195.1 - 6.7e-11 42.1 0.2 1.4e-10 41.0 0.2 1.5 2 0 0 2 2 2 1 Complex 1 protein (LYR family) Acetyltransf_1 PF00583.25 EMD62196.1 - 5.2e-16 58.9 0.0 1.4e-15 57.5 0.0 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EMD62196.1 - 4.2e-08 33.5 0.0 6.9e-08 32.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EMD62196.1 - 6.3e-08 32.6 0.0 1.3e-07 31.5 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EMD62196.1 - 1.1e-06 28.5 0.0 1.9e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_4 PF13420.7 EMD62196.1 - 0.0031 17.7 0.0 0.0075 16.4 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EMD62196.1 - 0.11 12.7 0.0 0.19 11.9 0.0 1.4 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase MOZART1 PF12554.8 EMD62196.1 - 0.19 11.5 0.3 0.33 10.8 0.3 1.3 1 0 0 1 1 1 0 Mitotic-spindle organizing gamma-tubulin ring associated ABC_tran PF00005.27 EMD62197.1 - 2.4e-47 160.9 0.2 3.3e-24 85.9 0.0 2.4 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 EMD62197.1 - 5.3e-24 85.6 4.5 5.7e-06 26.4 0.0 4.3 3 1 0 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system ABC2_membrane_3 PF12698.7 EMD62197.1 - 1.3e-22 80.4 55.4 8.3e-15 54.7 30.2 2.6 3 0 0 3 3 3 2 ABC-2 family transporter protein AAA_29 PF13555.6 EMD62197.1 - 2.9e-08 33.3 1.1 8.4e-05 22.2 0.2 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain SMC_N PF02463.19 EMD62197.1 - 3.1e-08 33.3 5.4 0.027 13.9 0.0 3.9 4 0 0 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EMD62197.1 - 1.5e-06 28.9 1.9 0.018 15.5 0.1 2.4 2 0 0 2 2 2 2 AAA domain AAA_15 PF13175.6 EMD62197.1 - 6e-06 26.2 0.0 0.021 14.5 0.1 3.2 3 0 0 3 3 3 1 AAA ATPase domain RsgA_GTPase PF03193.16 EMD62197.1 - 5.6e-05 23.1 0.3 0.37 10.7 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase AAA_27 PF13514.6 EMD62197.1 - 0.00072 19.2 0.3 0.35 10.4 0.1 2.3 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EMD62197.1 - 0.0042 17.5 0.2 2.4 8.5 0.1 2.5 2 0 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 EMD62197.1 - 0.0073 16.6 0.1 0.33 11.2 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EMD62197.1 - 0.016 14.9 0.5 1.7 8.3 0.1 2.5 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 EMD62197.1 - 0.11 11.7 0.3 3.1 7.0 0.1 2.2 2 0 0 2 2 2 0 Zeta toxin DUF4162 PF13732.6 EMD62197.1 - 0.14 12.9 0.0 24 5.7 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4162) AAA_28 PF13521.6 EMD62197.1 - 0.57 10.4 1.5 5.1 7.3 0.4 2.4 2 0 0 2 2 2 0 AAA domain DUF2116 PF09889.9 EMD62198.1 - 0.14 12.2 0.1 0.22 11.5 0.1 1.3 1 0 0 1 1 1 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) YHS PF04945.13 EMD62198.1 - 0.14 12.3 0.8 0.25 11.5 0.8 1.3 1 0 0 1 1 1 0 YHS domain ATF7IP_BD PF16788.5 EMD62199.1 - 2.9 7.9 5.1 95 3.0 6.0 2.1 2 0 0 2 2 2 0 ATF-interacting protein binding domain Hamartin PF04388.12 EMD62199.1 - 8.7 4.9 7.8 9.8 4.7 7.8 1.1 1 0 0 1 1 1 0 Hamartin protein NAD_binding_10 PF13460.6 EMD62201.1 - 0.0028 17.6 0.0 0.0036 17.2 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EMD62201.1 - 0.0047 16.4 0.1 0.0074 15.8 0.1 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 EMD62201.1 - 0.01 15.0 0.0 0.015 14.5 0.0 1.2 1 0 0 1 1 1 0 Male sterility protein KR PF08659.10 EMD62201.1 - 0.064 13.2 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 KR domain Polysacc_synt_2 PF02719.15 EMD62201.1 - 0.15 11.1 0.0 0.2 10.8 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein LRR_8 PF13855.6 EMD62202.1 - 1.3e-06 28.0 3.1 1.3e-06 28.0 3.1 1.7 2 0 0 2 2 2 1 Leucine rich repeat LRR_4 PF12799.7 EMD62202.1 - 0.0044 17.4 4.5 0.66 10.5 2.1 2.5 1 1 0 2 2 2 2 Leucine Rich repeats (2 copies) VATC PF18716.1 EMD62202.1 - 0.16 11.8 1.2 0.42 10.5 1.2 1.6 1 0 0 1 1 1 0 Vms1-associating treble clef domain AA_permease PF00324.21 EMD62203.1 - 1.4e-110 370.1 36.7 1.8e-110 369.8 36.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EMD62203.1 - 2.4e-23 82.7 43.0 2.9e-23 82.4 43.0 1.0 1 0 0 1 1 1 1 Amino acid permease MTTB PF06253.11 EMD62204.1 - 0.012 13.6 0.0 0.016 13.2 0.0 1.1 1 0 0 1 1 1 0 Trimethylamine methyltransferase (MTTB) MFS_1 PF07690.16 EMD62205.1 - 1.6e-33 116.1 33.1 2.3e-33 115.6 33.1 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_4 PF06779.14 EMD62205.1 - 0.0017 17.7 6.5 0.0017 17.7 6.5 2.7 2 1 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB FixQ PF05545.11 EMD62206.1 - 0.2 11.6 0.0 0.32 11.0 0.0 1.3 1 0 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ Glyco_hydro_7 PF00840.20 EMD62207.1 - 6.4e-203 674.3 17.5 7.2e-203 674.1 17.5 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 7 Nairovirus_M PF07948.11 EMD62207.1 - 0.083 11.1 0.1 0.11 10.6 0.1 1.3 1 0 0 1 1 1 0 Nairovirus M polyprotein-like Fungal_trans PF04082.18 EMD62208.1 - 3.6e-13 49.2 2.1 5.2e-13 48.6 2.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD62208.1 - 4.2e-08 33.2 6.7 9.6e-08 32.0 6.7 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF2046 PF09755.9 EMD62208.1 - 0.018 14.3 0.6 0.03 13.5 0.6 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein H4 (DUF2046) Peptidase_C74 PF12387.8 EMD62208.1 - 0.31 10.5 2.6 26 4.2 2.7 2.3 2 0 0 2 2 2 0 Pestivirus NS2 peptidase Isochorismatase PF00857.20 EMD62212.1 - 4.3e-26 92.2 0.0 8.1e-26 91.2 0.0 1.4 1 1 0 1 1 1 1 Isochorismatase family Glyco_hydro_7 PF00840.20 EMD62213.1 - 9.6e-138 459.5 10.0 1.2e-137 459.2 10.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 7 Cu_amine_oxid PF01179.20 EMD62215.1 - 7e-123 410.6 5.3 9.6e-123 410.1 5.3 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain DUF1965 PF09248.10 EMD62215.1 - 6e-31 106.0 0.1 1.2e-30 105.1 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1965) Cu_amine_oxidN2 PF02727.16 EMD62215.1 - 0.00065 19.9 0.0 0.0012 19.0 0.0 1.4 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain Na_Ca_ex PF01699.24 EMD62217.1 - 7.9e-52 175.2 37.3 2.9e-28 98.7 16.5 3.1 2 1 1 3 3 3 2 Sodium/calcium exchanger protein Cnd2 PF05786.14 EMD62218.1 - 5.1e-284 944.7 2.4 5.8e-284 944.5 2.4 1.0 1 0 0 1 1 1 1 Condensin complex subunit 2 DASH_Spc19 PF08287.11 EMD62218.1 - 0.081 12.8 0.2 0.081 12.8 0.2 1.8 2 0 0 2 2 2 0 Spc19 CNDH2_N PF06278.11 EMD62218.1 - 0.087 13.0 0.0 0.22 11.7 0.0 1.7 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal Nop14 PF04147.12 EMD62220.1 - 0.0006 18.2 10.1 0.0006 18.2 10.1 2.8 3 0 0 3 3 3 1 Nop14-like family NOA36 PF06524.12 EMD62220.1 - 0.0048 16.3 17.5 0.0048 16.3 17.5 2.6 2 1 1 3 3 3 1 NOA36 protein Cytochrom_C1 PF02167.15 EMD62221.1 - 8.7e-93 310.1 0.0 1.1e-92 309.7 0.0 1.1 1 0 0 1 1 1 1 Cytochrome C1 family Cytochrome_CBB3 PF13442.6 EMD62221.1 - 0.0053 17.0 0.0 0.013 15.8 0.0 1.8 1 0 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C PF00034.21 EMD62221.1 - 0.018 16.2 0.1 0.091 13.9 0.0 2.2 2 0 0 2 2 2 0 Cytochrome c Peptidase_M1 PF01433.20 EMD62222.1 - 4.5e-85 284.6 1.1 7.7e-85 283.9 1.1 1.4 1 0 0 1 1 1 1 Peptidase family M1 domain ERAP1_C PF11838.8 EMD62222.1 - 1.2e-81 274.7 0.2 1.1e-80 271.6 0.0 2.3 2 1 0 2 2 2 1 ERAP1-like C-terminal domain Peptidase_M1_N PF17900.1 EMD62222.1 - 1.7e-52 178.3 1.8 6.4e-52 176.5 1.4 2.0 2 0 0 2 2 2 1 Peptidase M1 N-terminal domain DUF2808 PF10989.8 EMD62222.1 - 0.0036 17.3 0.1 0.0088 16.0 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2808) DUF3543 PF12063.8 EMD62224.1 - 2.9e-79 266.0 0.0 5.2e-79 265.2 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3543) Pkinase PF00069.25 EMD62224.1 - 1.1e-60 205.2 0.0 4.5e-60 203.2 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD62224.1 - 2.1e-44 151.8 0.0 4.3e-44 150.7 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Pro_isomerase PF00160.21 EMD62225.1 - 1.8e-51 174.6 0.2 3.8e-51 173.5 0.2 1.6 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD WD40 PF00400.32 EMD62225.1 - 6.2e-11 42.7 0.1 0.00019 22.2 0.0 4.5 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD62225.1 - 2e-05 24.8 0.0 0.039 14.2 0.0 3.2 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EMD62225.1 - 0.0031 16.5 0.5 0.6 9.0 0.1 2.5 1 1 1 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein AAA PF00004.29 EMD62226.1 - 2.6e-42 144.4 0.0 4.4e-42 143.6 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EMD62226.1 - 3.5e-12 45.9 0.0 8.2e-12 44.7 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 EMD62226.1 - 1.8e-11 43.8 0.1 9.5e-11 41.5 0.0 2.1 2 0 0 2 2 2 1 Proteasomal ATPase OB C-terminal domain AAA_16 PF13191.6 EMD62226.1 - 8.6e-08 32.7 0.0 5.7e-05 23.6 0.1 2.9 2 1 1 3 3 3 1 AAA ATPase domain AAA_5 PF07728.14 EMD62226.1 - 1.5e-06 28.3 0.1 3.2e-05 23.9 0.1 2.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 EMD62226.1 - 3.1e-06 27.4 0.0 9.5e-06 25.8 0.0 1.8 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 EMD62226.1 - 7.3e-06 25.8 0.0 1.5e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EMD62226.1 - 0.00018 21.8 0.2 0.0036 17.6 0.1 2.5 2 1 0 2 2 1 1 AAA domain DUF815 PF05673.13 EMD62226.1 - 0.00036 19.8 0.0 0.00085 18.6 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_18 PF13238.6 EMD62226.1 - 0.00077 20.0 0.0 0.0031 18.0 0.0 2.0 2 1 0 2 2 1 1 AAA domain AAA_7 PF12775.7 EMD62226.1 - 0.0012 18.4 0.0 0.0024 17.4 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region TIP49 PF06068.13 EMD62226.1 - 0.0023 17.2 0.0 0.0044 16.3 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_33 PF13671.6 EMD62226.1 - 0.0033 17.6 0.0 0.01 16.0 0.0 1.9 2 0 0 2 2 1 1 AAA domain Mg_chelatase PF01078.21 EMD62226.1 - 0.0042 16.5 0.0 0.008 15.6 0.0 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI Prot_ATP_OB_N PF17758.1 EMD62226.1 - 0.0044 16.6 0.0 0.012 15.2 0.0 1.7 1 0 0 1 1 1 1 Proteasomal ATPase OB N-terminal domain TsaE PF02367.17 EMD62226.1 - 0.0047 16.9 0.0 0.0093 16.0 0.0 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE IstB_IS21 PF01695.17 EMD62226.1 - 0.0061 16.3 0.0 0.013 15.3 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein RNA_helicase PF00910.22 EMD62226.1 - 0.0061 16.9 0.0 0.012 16.0 0.0 1.5 1 0 0 1 1 1 1 RNA helicase AAA_14 PF13173.6 EMD62226.1 - 0.008 16.2 0.0 0.017 15.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain Sigma54_activat PF00158.26 EMD62226.1 - 0.0082 15.9 0.0 0.028 14.1 0.0 1.9 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_3 PF07726.11 EMD62226.1 - 0.014 15.3 0.0 0.03 14.2 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ATPase PF06745.13 EMD62226.1 - 0.023 14.0 0.1 0.13 11.6 0.0 2.2 2 0 0 2 2 2 0 KaiC AAA_24 PF13479.6 EMD62226.1 - 0.028 14.1 0.0 0.057 13.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 EMD62226.1 - 0.044 13.5 0.0 0.11 12.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 EMD62226.1 - 0.054 13.4 0.1 0.15 12.0 0.0 1.7 2 0 0 2 2 2 0 NACHT domain PhoH PF02562.16 EMD62226.1 - 0.066 12.7 0.0 0.12 11.8 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein AAA_28 PF13521.6 EMD62226.1 - 0.095 12.9 0.0 0.17 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 EMD62226.1 - 0.1 12.2 0.0 0.22 11.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 EMD62226.1 - 0.11 12.3 0.2 0.26 11.0 0.0 1.7 2 0 0 2 2 2 0 AAA domain Parvo_NS1 PF01057.17 EMD62226.1 - 0.13 11.4 0.0 0.22 10.6 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Zeta_toxin PF06414.12 EMD62226.1 - 0.13 11.5 0.0 0.26 10.5 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin WD40 PF00400.32 EMD62227.1 - 2.8e-12 46.9 5.5 0.071 14.0 0.1 5.6 5 0 0 5 5 5 4 WD domain, G-beta repeat DUF1754 PF08555.10 EMD62227.1 - 1.2 9.9 5.1 3.4 8.5 5.1 1.7 1 0 0 1 1 1 0 Eukaryotic family of unknown function (DUF1754) 3Beta_HSD PF01073.19 EMD62228.1 - 1.8e-61 207.6 0.0 2.1e-61 207.4 0.0 1.0 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EMD62228.1 - 2.3e-37 128.8 0.0 3.2e-37 128.3 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EMD62228.1 - 9.3e-22 77.8 0.0 7.6e-21 74.8 0.0 2.0 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 EMD62228.1 - 2.6e-15 56.3 0.0 3.7e-15 55.8 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.12 EMD62228.1 - 2.7e-15 56.2 1.4 2e-10 40.3 0.0 2.2 2 0 0 2 2 2 2 Male sterility protein Polysacc_synt_2 PF02719.15 EMD62228.1 - 1.3e-11 44.2 0.0 4.1e-11 42.5 0.0 1.8 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.6 EMD62228.1 - 4.8e-11 42.9 0.0 1e-10 41.8 0.0 1.5 1 1 1 2 2 2 1 NAD(P)H-binding KR PF08659.10 EMD62228.1 - 7.9e-10 38.9 0.0 1.9e-09 37.7 0.0 1.6 1 1 0 1 1 1 1 KR domain NmrA PF05368.13 EMD62228.1 - 0.00014 21.6 0.0 0.00021 20.9 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family adh_short PF00106.25 EMD62228.1 - 0.0058 16.1 0.0 0.0093 15.4 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase eIF2A PF08662.11 EMD62229.1 - 1.7e-39 135.8 2.8 5.8e-36 124.2 0.3 4.0 3 2 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A RRM_1 PF00076.22 EMD62229.1 - 1.7e-05 24.5 0.0 5.3e-05 23.0 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Val_tRNA-synt_C PF10458.9 EMD62229.1 - 0.087 13.1 0.6 0.42 10.9 0.6 2.1 1 0 0 1 1 1 0 Valyl tRNA synthetase tRNA binding arm TetR_C_28 PF17937.1 EMD62229.1 - 0.11 13.0 0.3 0.23 11.9 0.3 1.6 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain Methyltr_RsmF_N PF17125.5 EMD62229.1 - 0.15 12.6 0.9 2.6 8.6 0.1 3.0 3 1 1 4 4 4 0 N-terminal domain of 16S rRNA methyltransferase RsmF WD40 PF00400.32 EMD62229.1 - 0.16 12.9 0.6 25 6.0 0.0 4.0 4 0 0 4 4 4 0 WD domain, G-beta repeat RE_HindIII PF09518.10 EMD62229.1 - 0.21 10.8 1.8 0.33 10.1 1.8 1.2 1 0 0 1 1 1 0 HindIII restriction endonuclease ArfGap PF01412.18 EMD62230.1 - 7.3e-34 116.3 0.2 2.9e-33 114.4 0.0 2.1 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf BAR_3 PF16746.5 EMD62230.1 - 1.8e-19 70.4 11.6 2.9e-19 69.7 11.6 1.2 1 0 0 1 1 1 1 BAR domain of APPL family PH PF00169.29 EMD62230.1 - 9.3e-12 45.4 0.1 2.5e-11 44.0 0.1 1.8 1 0 0 1 1 1 1 PH domain TF_Zn_Ribbon PF08271.12 EMD62230.1 - 0.17 11.4 0.0 0.46 10.0 0.0 1.6 1 0 0 1 1 1 0 TFIIB zinc-binding CheZ PF04344.13 EMD62230.1 - 1.2 9.0 5.4 6.8 6.6 0.4 2.7 3 0 0 3 3 3 0 Chemotaxis phosphatase, CheZ Dak2 PF02734.17 EMD62230.1 - 6.1 6.7 5.4 3 7.7 0.3 2.7 3 0 0 3 3 3 0 DAK2 domain ATP11 PF06644.11 EMD62231.1 - 3.5e-92 309.1 0.0 4.1e-92 308.8 0.0 1.0 1 0 0 1 1 1 1 ATP11 protein CdiI_2 PF18593.1 EMD62231.1 - 0.014 16.0 0.5 1.7 9.3 0.1 2.8 3 0 0 3 3 3 0 CdiI immunity protein GUCT PF08152.12 EMD62231.1 - 0.032 14.5 0.0 0.08 13.2 0.0 1.6 1 0 0 1 1 1 0 GUCT (NUC152) domain Pex2_Pex12 PF04757.14 EMD62232.1 - 4.7e-41 140.8 2.6 5.7e-41 140.6 2.6 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_2 PF13923.6 EMD62232.1 - 5.7e-11 42.1 9.1 9.3e-11 41.4 9.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EMD62232.1 - 1.4e-10 41.3 9.4 2.2e-10 40.7 9.4 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 EMD62232.1 - 8.3e-10 38.4 7.3 1.4e-09 37.7 7.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EMD62232.1 - 1.3e-09 38.0 2.4 1.3e-09 38.0 2.4 1.6 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EMD62232.1 - 1.6e-09 37.5 8.7 2.4e-09 36.9 8.7 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EMD62232.1 - 1.7e-07 31.1 6.3 2.9e-07 30.3 6.3 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.7 EMD62232.1 - 1.9e-06 28.1 6.8 3.7e-06 27.1 6.8 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 EMD62232.1 - 2e-06 27.6 10.4 3.1e-06 26.9 10.4 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 EMD62232.1 - 2e-05 24.6 7.8 3.6e-05 23.8 7.8 1.4 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_10 PF16685.5 EMD62232.1 - 0.0099 16.0 8.9 0.017 15.2 8.9 1.3 1 0 0 1 1 1 1 zinc RING finger of MSL2 zf-RING_6 PF14835.6 EMD62232.1 - 0.019 14.8 4.9 0.037 13.9 4.9 1.4 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-RING_11 PF17123.5 EMD62232.1 - 0.097 12.4 3.9 0.22 11.3 3.9 1.6 1 0 0 1 1 1 0 RING-like zinc finger zf-RING_4 PF14570.6 EMD62232.1 - 0.11 12.4 6.9 0.21 11.4 6.9 1.5 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-ANAPC11 PF12861.7 EMD62232.1 - 0.15 12.1 3.6 0.28 11.3 3.6 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger U-box PF04564.15 EMD62232.1 - 0.21 11.8 0.0 0.45 10.7 0.0 1.5 1 0 0 1 1 1 0 U-box domain Chromo PF00385.24 EMD62233.1 - 2.2e-06 27.5 2.0 2.2e-06 27.5 2.0 2.0 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain Pinin_SDK_N PF04697.13 EMD62233.1 - 0.37 11.4 5.9 8.6 7.0 0.9 2.8 2 0 0 2 2 2 0 pinin/SDK conserved region DUF5320 PF17253.2 EMD62233.1 - 1.4 10.0 10.2 5.6 8.1 0.7 2.9 3 0 0 3 3 3 0 Family of unknown function (DUF5320) MFS_1 PF07690.16 EMD62234.1 - 2.4e-22 79.3 49.3 2.4e-22 79.3 49.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_3 PF05977.13 EMD62234.1 - 0.11 10.9 10.9 0.014 13.8 4.9 2.0 2 0 0 2 2 2 0 Transmembrane secretion effector PsbN PF02468.15 EMD62234.1 - 0.35 10.8 3.9 10 6.1 0.1 3.1 2 0 0 2 2 2 0 Photosystem II reaction centre N protein (psbN) DUF5424 PF17462.2 EMD62236.1 - 0.17 11.8 0.0 0.21 11.5 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5424) DUF963 PF06131.11 EMD62237.1 - 1.6e-07 30.6 32.1 1.3e-05 24.5 10.0 4.6 2 2 1 3 3 3 2 Schizosaccharomyces pombe repeat of unknown function (DUF963) Caud_tail_N PF16838.5 EMD62239.1 - 0.046 14.2 0.5 0.086 13.3 0.5 1.5 1 0 0 1 1 1 0 Caudoviral major tail protein N-terminus MFS_1 PF07690.16 EMD62240.1 - 5.3e-18 65.1 52.6 3.3e-15 55.9 27.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1 PF07690.16 EMD62241.1 - 3.3e-36 124.9 27.8 3.3e-36 124.9 27.8 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily Antimicrobial_2 PF08023.12 EMD62241.1 - 0.1 13.2 0.1 0.22 12.1 0.1 1.6 1 0 0 1 1 1 0 Frog antimicrobial peptide DUF4131 PF13567.6 EMD62241.1 - 5.6 6.6 9.3 4.6 6.9 0.2 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4131) DUF485 PF04341.12 EMD62241.1 - 5.7 7.0 6.9 58 3.7 0.0 3.6 3 1 0 3 3 3 0 Protein of unknown function, DUF485 Amidohydro_2 PF04909.14 EMD62242.1 - 3.8e-17 63.0 0.1 1.9e-16 60.7 0.1 1.8 1 1 0 1 1 1 1 Amidohydrolase Glyco_hydro_31 PF01055.26 EMD62243.1 - 1.3e-104 350.8 0.7 2.4e-104 350.0 0.7 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 EMD62243.1 - 8.1e-05 22.9 0.7 0.00021 21.5 0.7 1.8 1 0 0 1 1 1 1 Galactose mutarotase-like DUF5110 PF17137.4 EMD62243.1 - 0.00044 20.5 0.0 0.0016 18.7 0.0 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF5110) F-box-like PF12937.7 EMD62245.1 - 0.0021 17.9 0.1 0.0021 17.9 0.1 2.0 2 0 0 2 2 2 1 F-box-like F-box_4 PF15966.5 EMD62245.1 - 0.01 15.7 0.0 0.023 14.6 0.0 1.5 1 0 0 1 1 1 0 F-box F-box PF00646.33 EMD62245.1 - 0.024 14.5 0.0 0.07 13.0 0.0 1.8 1 0 0 1 1 1 0 F-box domain DUF2267 PF10025.9 EMD62247.1 - 0.0099 16.2 0.2 0.026 14.8 0.2 1.7 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2267) DUF1572 PF07609.11 EMD62247.1 - 0.061 13.1 0.2 0.12 12.1 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1572) ARL2_Bind_BART PF11527.8 EMD62247.1 - 0.37 10.9 1.5 0.56 10.3 0.1 2.0 3 0 0 3 3 3 0 The ARF-like 2 binding protein BART TPR_10 PF13374.6 EMD62248.1 - 1.7e-27 94.5 0.4 4.5e-10 39.1 0.0 3.0 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.6 EMD62248.1 - 8.2e-24 83.7 0.3 3.1e-12 46.6 0.1 2.0 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.6 EMD62248.1 - 1.5e-05 25.0 1.4 0.54 10.8 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 EMD62248.1 - 0.00014 21.7 0.4 0.071 13.2 0.0 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 EMD62248.1 - 0.00041 20.0 1.5 5.9 6.9 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 EMD62248.1 - 0.0014 18.6 0.2 16 5.9 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 EMD62248.1 - 0.017 15.3 0.8 11 6.5 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat Glyco_hydro_18 PF00704.28 EMD62250.1 - 1.2e-63 215.8 1.9 1.3e-63 215.7 0.8 1.6 2 0 0 2 2 2 1 Glycosyl hydrolases family 18 Chitin_bind_1 PF00187.19 EMD62250.1 - 1.2e-15 57.6 47.3 8.4e-13 48.6 20.8 4.3 4 0 0 4 4 4 2 Chitin recognition protein LysM PF01476.20 EMD62251.1 - 1.7e-17 63.2 7.3 0.0015 18.6 0.1 6.6 6 0 0 6 6 6 6 LysM domain DUF4219 PF13961.6 EMD62253.1 - 0.042 13.5 1.3 0.063 13.0 1.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4219) Integrase_H2C2 PF17921.1 EMD62254.1 - 2.1e-05 24.5 0.0 3.3e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 Integrase zinc binding domain adh_short PF00106.25 EMD62255.1 - 2.4e-16 59.8 0.0 4.7e-16 58.8 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD62255.1 - 2.5e-07 30.5 0.0 4.2e-07 29.8 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD62255.1 - 1.6e-05 24.9 0.0 2.7e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 KR domain HET PF06985.11 EMD62256.1 - 2.1e-27 96.3 0.5 3.4e-27 95.6 0.5 1.3 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) FYVE PF01363.21 EMD62257.1 - 5.9e-20 71.2 24.4 4.1e-15 55.7 8.8 3.2 3 0 0 3 3 3 2 FYVE zinc finger Rbsn PF11464.8 EMD62257.1 - 7.3e-19 67.2 0.7 2.2e-18 65.7 0.7 1.9 1 0 0 1 1 1 1 Rabenosyn Rab binding domain zf-AN1 PF01428.16 EMD62257.1 - 0.0038 17.4 0.7 0.0038 17.4 0.7 3.8 4 1 1 5 5 4 1 AN1-like Zinc finger YqaH PF17448.2 EMD62257.1 - 0.092 13.1 0.1 0.24 11.7 0.1 1.7 1 0 0 1 1 1 0 Uncharacterized YqaH-like zf-Di19 PF05605.12 EMD62257.1 - 0.18 12.2 0.0 0.18 12.2 0.0 3.3 4 0 0 4 4 3 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.6 EMD62257.1 - 0.19 12.7 27.1 1.8 9.6 0.0 5.7 5 1 1 6 6 5 0 C2H2-type zinc finger Seryl_tRNA_N PF02403.22 EMD62257.1 - 0.26 11.5 2.0 0.52 10.6 0.6 2.2 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain C6_DPF PF10170.9 EMD62257.1 - 0.29 11.5 6.1 0.078 13.4 0.7 2.6 2 1 0 2 2 2 0 Cysteine-rich domain ABC_tran_CTD PF16326.5 EMD62257.1 - 0.82 10.0 5.0 28 5.1 1.1 3.5 3 0 0 3 3 3 0 ABC transporter C-terminal domain CtIP_N PF10482.9 EMD62257.1 - 1.2 9.2 7.7 8.3 6.5 0.9 3.2 3 1 0 3 3 3 0 Tumour-suppressor protein CtIP N-terminal domain Val_tRNA-synt_C PF10458.9 EMD62257.1 - 1.3 9.3 4.9 17 5.8 0.0 3.2 3 0 0 3 3 2 0 Valyl tRNA synthetase tRNA binding arm zf-C2HC5 PF06221.13 EMD62257.1 - 2.6 8.1 18.2 2.1 8.4 0.1 4.7 4 1 1 5 5 5 0 Putative zinc finger motif, C2HC5-type DUF2225 PF09986.9 EMD62257.1 - 5 6.8 6.4 2.5 7.8 2.9 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) zinc_ribbon_9 PF14369.6 EMD62257.1 - 7.9 6.8 10.8 24 5.3 0.1 4.1 4 0 0 4 4 3 0 zinc-ribbon Sirohm_synth_C PF14823.6 EMD62258.1 - 1.9e-30 104.3 0.0 2.8e-30 103.8 0.0 1.3 1 0 0 1 1 1 1 Sirohaem biosynthesis protein C-terminal NAD_binding_7 PF13241.6 EMD62258.1 - 2.7e-29 101.7 0.1 4.4e-29 101.0 0.1 1.3 1 0 0 1 1 1 1 Putative NAD(P)-binding Sirohm_synth_M PF14824.6 EMD62258.1 - 1e-14 53.6 0.2 1e-14 53.6 0.2 1.7 2 0 0 2 2 2 1 Sirohaem biosynthesis protein central bact-PGI_C PF10432.9 EMD62258.1 - 0.14 12.2 0.0 0.25 11.4 0.0 1.4 1 0 0 1 1 1 0 Bacterial phospho-glucose isomerase C-terminal SIS domain Methyltransf_10 PF05971.12 EMD62259.1 - 5.3e-52 177.0 0.0 7.3e-52 176.6 0.0 1.1 1 0 0 1 1 1 1 RNA methyltransferase MTS PF05175.14 EMD62259.1 - 1.3e-05 24.9 0.0 2.3e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 EMD62259.1 - 0.01 15.3 0.0 0.018 14.5 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_18 PF12847.7 EMD62259.1 - 0.041 13.8 0.0 0.073 13.0 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.6 EMD62259.1 - 0.19 12.5 0.0 0.57 10.9 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain tRNA-synt_1c PF00749.21 EMD62261.1 - 1.7e-95 319.5 0.0 2.4e-93 312.5 0.0 2.2 1 1 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 EMD62261.1 - 7.4e-32 110.6 0.0 1.8e-31 109.3 0.0 1.7 1 1 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain Fungal_trans_2 PF11951.8 EMD62262.1 - 6.5e-10 38.4 0.0 2e-09 36.8 0.0 1.6 1 1 0 1 1 1 1 Fungal specific transcription factor domain E1-E2_ATPase PF00122.20 EMD62263.1 - 5e-19 68.5 0.0 1.4e-18 67.1 0.0 1.8 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 EMD62263.1 - 7.8e-19 68.8 0.8 1.2e-11 45.3 2.1 3.0 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EMD62263.1 - 0.00037 20.5 0.1 0.021 14.9 0.1 2.5 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EMD62263.1 - 0.0021 17.8 0.0 0.073 12.8 0.0 2.6 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EMD62263.1 - 0.027 14.2 0.0 0.066 12.9 0.0 1.7 1 0 0 1 1 1 0 Cation transporter/ATPase, N-terminus DUF4059 PF13268.6 EMD62263.1 - 1.3 9.5 3.7 34 4.9 0.0 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF4059) HAD_2 PF13419.6 EMD62265.1 - 0.00011 22.4 0.0 0.00017 21.8 0.0 1.3 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EMD62265.1 - 0.014 15.7 0.0 0.018 15.3 0.0 1.4 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 EMD62265.1 - 0.079 13.1 0.0 0.26 11.4 0.0 2.0 2 1 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Radical_SAM PF04055.21 EMD62265.1 - 0.14 12.5 0.0 0.35 11.2 0.0 1.6 2 0 0 2 2 2 0 Radical SAM superfamily Carn_acyltransf PF00755.20 EMD62267.1 - 1.6e-208 694.1 0.1 1.8e-208 693.9 0.1 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase Ldh_1_C PF02866.18 EMD62268.1 - 9.6e-45 152.5 0.0 4.6e-44 150.3 0.0 2.0 2 0 0 2 2 2 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.23 EMD62268.1 - 1.1e-42 145.5 0.1 1.7e-42 144.8 0.1 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain 3Beta_HSD PF01073.19 EMD62268.1 - 0.0052 15.8 0.0 0.0076 15.3 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Semialdhyde_dh PF01118.24 EMD62268.1 - 0.063 13.7 0.1 0.65 10.4 0.0 2.4 2 1 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain PGAP1 PF07819.13 EMD62272.1 - 4.3e-92 308.0 0.0 6.5e-92 307.4 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_6 PF12697.7 EMD62272.1 - 1.6e-06 28.9 0.8 1.6e-06 28.9 0.8 1.9 2 0 0 2 2 2 1 Alpha/beta hydrolase family Palm_thioest PF02089.15 EMD62272.1 - 0.0016 18.3 0.0 0.0035 17.2 0.0 1.6 1 1 0 1 1 1 1 Palmitoyl protein thioesterase DUF676 PF05057.14 EMD62272.1 - 0.0032 17.0 0.1 0.0067 16.0 0.1 1.4 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Hydrolase_4 PF12146.8 EMD62272.1 - 0.0041 16.4 0.0 0.011 15.0 0.0 1.7 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EMD62272.1 - 0.008 15.9 0.0 0.024 14.3 0.0 1.7 1 0 0 1 1 1 1 alpha/beta hydrolase fold LCAT PF02450.15 EMD62272.1 - 0.026 13.7 0.0 0.042 13.0 0.0 1.2 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase RIBIOP_C PF04950.12 EMD62274.1 - 1.5e-96 323.3 0.1 1.5e-96 323.3 0.1 1.6 2 0 0 2 2 1 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 EMD62274.1 - 2.3e-28 98.1 0.0 6.8e-28 96.6 0.0 1.9 1 0 0 1 1 1 1 AARP2CN (NUC121) domain GTP_EFTU PF00009.27 EMD62274.1 - 4.3e-06 26.4 0.0 0.00053 19.6 0.0 2.4 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain AAA_22 PF13401.6 EMD62274.1 - 1.2e-05 25.6 0.0 2.7e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EMD62274.1 - 0.00016 22.1 0.0 0.00046 20.6 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 EMD62274.1 - 0.0002 21.8 0.0 0.00044 20.7 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 EMD62274.1 - 0.00028 21.1 1.1 0.00085 19.5 0.0 2.3 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 EMD62274.1 - 0.0006 19.9 0.0 0.0017 18.4 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.27 EMD62274.1 - 0.0017 18.9 0.0 0.0059 17.1 0.0 1.9 1 0 0 1 1 1 1 ABC transporter NACHT PF05729.12 EMD62274.1 - 0.0049 16.8 0.0 0.0086 16.0 0.0 1.3 1 0 0 1 1 1 1 NACHT domain AAA_19 PF13245.6 EMD62274.1 - 0.0058 17.0 0.1 0.012 15.9 0.1 1.4 1 0 0 1 1 1 1 AAA domain NB-ARC PF00931.22 EMD62274.1 - 0.0067 15.6 0.0 0.012 14.8 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain AAA_7 PF12775.7 EMD62274.1 - 0.014 15.0 0.0 0.029 13.9 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region RNA_helicase PF00910.22 EMD62274.1 - 0.016 15.6 0.0 0.037 14.4 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_18 PF13238.6 EMD62274.1 - 0.019 15.5 10.3 0.05 14.1 0.1 4.0 3 0 0 3 3 3 0 AAA domain cobW PF02492.19 EMD62274.1 - 0.026 14.1 0.1 0.048 13.3 0.1 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain KAP_NTPase PF07693.14 EMD62274.1 - 0.027 13.7 0.0 0.046 12.9 0.0 1.3 1 0 0 1 1 1 0 KAP family P-loop domain AAA_24 PF13479.6 EMD62274.1 - 0.028 14.1 0.0 0.081 12.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 EMD62274.1 - 0.034 14.1 0.0 0.094 12.6 0.0 1.7 1 0 0 1 1 1 0 RsgA GTPase NTPase_1 PF03266.15 EMD62274.1 - 0.034 14.1 0.3 0.066 13.1 0.3 1.5 1 0 0 1 1 1 0 NTPase AAA_30 PF13604.6 EMD62274.1 - 0.034 13.9 0.0 0.064 13.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 EMD62274.1 - 0.074 13.0 0.1 0.18 11.8 0.1 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) MobB PF03205.14 EMD62274.1 - 0.088 12.7 0.0 0.28 11.1 0.0 1.9 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B TsaE PF02367.17 EMD62274.1 - 0.089 12.8 0.0 1 9.4 0.0 2.2 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_14 PF13173.6 EMD62274.1 - 0.089 12.8 0.0 0.24 11.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain Roc PF08477.13 EMD62274.1 - 0.092 13.0 0.0 0.25 11.5 0.0 1.7 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase PduV-EutP PF10662.9 EMD62274.1 - 0.11 12.2 0.0 0.69 9.6 0.0 2.0 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation SRP54 PF00448.22 EMD62274.1 - 0.13 11.9 0.0 0.24 11.0 0.0 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain ATP_bind_1 PF03029.17 EMD62274.1 - 0.2 11.4 0.1 0.35 10.6 0.1 1.4 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein BCDHK_Adom3 PF10436.9 EMD62275.1 - 1e-44 152.2 0.2 1.4e-44 151.8 0.2 1.2 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 EMD62275.1 - 3e-10 40.6 0.2 8.9e-08 32.6 0.2 3.2 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 EMD62275.1 - 0.081 12.7 0.0 1.6 8.5 0.0 2.3 1 1 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase CRISPR_Cas6 PF10040.9 EMD62276.1 - 0.67 10.6 4.5 3.3 8.4 0.1 3.7 3 0 0 3 3 3 0 CRISPR-associated endoribonuclease Cas6 DUF2427 PF10348.9 EMD62276.1 - 6.4 6.6 5.8 2.5e+02 1.5 5.8 2.7 1 1 0 1 1 1 0 Domain of unknown function (DUF2427) HET PF06985.11 EMD62279.1 - 2.5e-34 118.7 0.8 4e-34 118.1 0.8 1.3 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Macro PF01661.21 EMD62280.1 - 6.5e-40 135.8 0.5 9.6e-40 135.3 0.5 1.3 1 0 0 1 1 1 1 Macro domain Sugar_tr PF00083.24 EMD62281.1 - 5.6e-112 374.9 21.7 6.4e-112 374.7 21.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD62281.1 - 1.4e-24 86.7 35.9 3.2e-21 75.7 14.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily YrhK PF14145.6 EMD62281.1 - 5.4 7.0 9.9 0.18 11.7 1.5 2.6 2 0 0 2 2 2 0 YrhK-like protein Pro_isomerase PF00160.21 EMD62282.1 - 1.3e-49 168.5 0.0 1.8e-49 168.1 0.0 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Amino_oxidase PF01593.24 EMD62283.1 - 2.2e-57 195.3 0.0 2.6e-57 195.1 0.0 1.0 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EMD62283.1 - 1.4e-10 41.2 0.1 3.6e-10 39.9 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EMD62283.1 - 7.7e-08 32.3 0.1 6.1e-07 29.3 0.0 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EMD62283.1 - 9.5e-08 31.5 3.4 1.8e-07 30.6 3.5 1.5 1 1 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 EMD62283.1 - 1.8e-06 27.6 1.8 2.5e-06 27.1 1.8 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 EMD62283.1 - 8e-06 24.8 0.9 2.5e-05 23.2 0.7 1.8 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox_2 PF07992.14 EMD62283.1 - 1.1e-05 24.8 0.9 1.8e-05 24.1 0.2 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EMD62283.1 - 2.9e-05 23.5 0.6 0.1 11.8 0.2 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EMD62283.1 - 4.6e-05 22.8 0.9 7.1e-05 22.2 0.9 1.2 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 EMD62283.1 - 0.00011 21.6 0.9 0.00017 20.9 0.2 1.6 2 0 0 2 2 2 1 Thi4 family Pyr_redox PF00070.27 EMD62283.1 - 0.00014 22.4 0.6 0.00037 21.0 0.6 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 EMD62283.1 - 0.00057 19.2 1.4 0.00096 18.5 1.4 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_9 PF13454.6 EMD62283.1 - 0.001 19.1 0.0 0.093 12.7 0.0 2.4 2 0 0 2 2 2 1 FAD-NAD(P)-binding GIDA PF01134.22 EMD62283.1 - 0.0014 17.8 0.7 0.0026 16.9 0.7 1.4 1 0 0 1 1 1 1 Glucose inhibited division protein A Lycopene_cycl PF05834.12 EMD62283.1 - 0.015 14.4 0.8 0.022 13.8 0.8 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein NAD_binding_7 PF13241.6 EMD62283.1 - 0.099 13.1 0.2 0.19 12.2 0.2 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding Ldh_2 PF02615.14 EMD62285.1 - 3e-124 414.5 0.8 3.4e-124 414.3 0.8 1.0 1 0 0 1 1 1 1 Malate/L-lactate dehydrogenase Acetyltransf_1 PF00583.25 EMD62286.1 - 3.8e-17 62.6 0.0 4.6e-17 62.3 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EMD62286.1 - 7.9e-08 32.6 0.0 1.1e-07 32.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EMD62286.1 - 8.8e-06 25.7 0.0 1e-05 25.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EMD62286.1 - 0.0003 20.7 0.0 0.00054 19.9 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.6 EMD62286.1 - 0.0089 16.1 0.0 0.016 15.3 0.0 1.5 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_15 PF17013.5 EMD62286.1 - 0.023 14.1 0.0 0.023 14.1 0.0 1.2 1 0 0 1 1 1 0 Putative acetyl-transferase Acetyltransf_4 PF13420.7 EMD62286.1 - 0.11 12.7 0.0 0.15 12.2 0.0 1.1 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Complex1_LYR PF05347.15 EMD62287.1 - 3.7e-05 23.7 1.4 5.2e-05 23.2 0.3 1.8 2 0 0 2 2 2 1 Complex 1 protein (LYR family) Ank_2 PF12796.7 EMD62288.1 - 8.3e-12 45.5 0.2 8.2e-05 23.1 0.0 3.4 1 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMD62288.1 - 1.3e-10 41.5 0.4 4.1e-05 24.0 0.1 4.0 2 2 2 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 EMD62288.1 - 1.8e-09 37.6 2.3 0.012 16.0 0.0 4.5 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.6 EMD62288.1 - 2.8e-08 33.4 3.4 0.06 13.9 0.0 4.8 4 1 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 EMD62288.1 - 3.3e-06 27.3 0.7 0.097 13.0 0.1 3.6 2 1 1 3 3 3 2 Ankyrin repeats (many copies) KilA-N PF04383.13 EMD62288.1 - 0.0007 19.4 1.9 0.0043 16.9 0.2 2.7 2 1 0 2 2 2 1 KilA-N domain GAT PF03127.14 EMD62288.1 - 4.3 7.7 7.6 0.9 9.9 1.0 2.7 3 0 0 3 3 3 0 GAT domain DUF3439 PF11921.8 EMD62288.1 - 7.5 6.5 8.7 0.36 10.8 2.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) Zn_clus PF00172.18 EMD62289.1 - 3.5e-08 33.4 10.6 5.6e-08 32.8 10.6 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EMD62290.1 - 1.7e-05 24.0 0.3 3.6e-05 22.9 0.3 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Pyr_redox_2 PF07992.14 EMD62291.1 - 1.7e-05 24.2 0.0 0.028 13.6 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase TetR_C_5 PF08360.11 EMD62291.1 - 0.096 12.9 0.0 0.19 11.9 0.0 1.4 1 0 0 1 1 1 0 QacR-like protein, C-terminal region Whi5 PF08528.11 EMD62293.1 - 1.5e-12 46.8 0.1 2.5e-12 46.1 0.1 1.3 1 0 0 1 1 1 1 Whi5 like AcetylCoA_hydro PF02550.15 EMD62294.1 - 1.3e-49 168.9 0.0 2.1e-49 168.2 0.0 1.3 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase N-terminal domain AcetylCoA_hyd_C PF13336.6 EMD62294.1 - 4.2e-41 140.5 0.0 7.5e-41 139.6 0.0 1.4 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase C-terminal domain CoA_trans PF01144.23 EMD62294.1 - 0.1 12.0 0.0 0.23 10.8 0.0 1.6 1 0 0 1 1 1 0 Coenzyme A transferase Palm_thioest PF02089.15 EMD62295.1 - 8.8e-75 251.7 0.0 1e-74 251.4 0.0 1.0 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Lipase_2 PF01674.18 EMD62295.1 - 0.0043 16.6 0.0 0.0084 15.6 0.0 1.7 1 1 0 1 1 1 1 Lipase (class 2) Ribosomal_L1 PF00687.21 EMD62297.1 - 5.5e-58 196.1 4.2 5.5e-58 196.1 4.2 1.5 2 0 0 2 2 2 1 Ribosomal protein L1p/L10e family zf-RRN7 PF11781.8 EMD62300.1 - 1.2e-06 28.1 1.5 2.4e-06 27.1 1.5 1.5 1 0 0 1 1 1 1 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 eIF-5a PF01287.20 EMD62301.1 - 6.8e-29 99.8 1.1 9.3e-29 99.3 1.1 1.2 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold EFP_N PF08207.12 EMD62301.1 - 0.0016 18.4 0.0 0.0031 17.5 0.0 1.5 1 0 0 1 1 1 1 Elongation factor P (EF-P) KOW-like domain Vps52 PF04129.12 EMD62302.1 - 1.7e-126 423.0 0.0 2e-126 422.8 0.0 1.0 1 0 0 1 1 1 1 Vps52 / Sac2 family Sec3_C PF09763.9 EMD62302.1 - 0.00038 19.0 0.7 0.00055 18.5 0.7 1.2 1 0 0 1 1 1 1 Exocyst complex component Sec3 Spc7 PF08317.11 EMD62302.1 - 0.011 14.6 0.3 0.021 13.7 0.3 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein Mer2 PF09074.10 EMD62302.1 - 0.041 13.7 0.1 6.8 6.4 0.0 3.0 3 0 0 3 3 3 0 Mer2 DUF1664 PF07889.12 EMD62302.1 - 0.1 12.6 0.1 0.25 11.4 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) GAS PF13851.6 EMD62302.1 - 0.11 11.8 1.6 0.24 10.7 1.6 1.5 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Xrn1_D3 PF18194.1 EMD62302.1 - 0.17 12.0 2.1 0.16 12.1 0.4 1.9 2 0 0 2 2 1 0 Exoribonuclease 1 Domain-3 DUF4795 PF16043.5 EMD62302.1 - 0.19 11.3 1.7 0.59 9.7 1.7 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) TSNAXIP1_N PF15739.5 EMD62302.1 - 0.22 11.9 3.3 16 5.9 0.0 3.4 3 0 0 3 3 3 0 Translin-associated factor X-interacting N-terminus Med4 PF10018.9 EMD62302.1 - 0.27 10.9 1.3 0.51 10.0 1.3 1.4 1 0 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 COG2 PF06148.11 EMD62302.1 - 0.41 10.7 5.8 2 8.5 0.7 3.4 4 0 0 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF1993 PF09351.10 EMD62303.1 - 2.7e-32 112.1 0.0 3.1e-32 112.0 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1993) 2OG-FeII_Oxy_3 PF13640.6 EMD62304.1 - 1.8e-08 35.1 0.0 3.6e-08 34.2 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Ribosomal_L29e PF01779.17 EMD62304.1 - 0.13 12.6 0.2 0.26 11.6 0.2 1.5 1 0 0 1 1 1 0 Ribosomal L29e protein family CLASP_N PF12348.8 EMD62305.1 - 3.2e-121 403.1 6.6 9.7e-87 290.3 0.1 2.5 2 0 0 2 2 2 2 CLASP N terminal HEAT PF02985.22 EMD62305.1 - 0.0029 17.7 1.1 42 4.8 0.0 5.0 4 0 0 4 4 4 1 HEAT repeat Cnd1 PF12717.7 EMD62305.1 - 0.12 12.4 0.1 11 6.0 0.0 3.4 3 0 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 DUF3361 PF11841.8 EMD62305.1 - 2.6 8.0 5.2 5.2 7.0 0.0 3.7 4 1 1 5 5 5 0 Domain of unknown function (DUF3361) Thi4 PF01946.17 EMD62306.1 - 7.4e-114 378.8 0.0 9.5e-114 378.5 0.0 1.1 1 0 0 1 1 1 1 Thi4 family DAO PF01266.24 EMD62306.1 - 3.4e-07 30.2 1.8 1.8e-06 27.8 1.4 2.0 1 1 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EMD62306.1 - 9.3e-05 21.8 0.0 0.00013 21.3 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EMD62306.1 - 0.00031 19.9 0.5 0.00031 19.9 0.5 2.3 3 0 0 3 3 3 1 Lycopene cyclase protein NAD_binding_8 PF13450.6 EMD62306.1 - 0.00037 20.7 0.7 0.0011 19.2 0.7 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EMD62306.1 - 0.00045 19.4 1.5 0.004 16.3 0.7 2.5 2 1 1 3 3 3 1 FAD binding domain NAD_binding_9 PF13454.6 EMD62306.1 - 0.00076 19.5 1.1 0.0013 18.7 0.1 1.9 3 0 0 3 3 3 1 FAD-NAD(P)-binding FAD_binding_3 PF01494.19 EMD62306.1 - 0.046 13.0 0.0 0.07 12.4 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain FAD_oxidored PF12831.7 EMD62306.1 - 0.053 12.9 0.1 0.073 12.4 0.1 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EMD62306.1 - 0.065 12.5 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EMD62306.1 - 0.2 10.3 0.6 0.32 9.6 0.6 1.3 1 0 0 1 1 1 0 HI0933-like protein RhoGAP PF00620.27 EMD62308.1 - 7.8e-46 155.7 0.0 2.2e-45 154.2 0.0 1.8 1 0 0 1 1 1 1 RhoGAP domain LIM PF00412.22 EMD62308.1 - 9.1e-14 51.4 18.5 1.9e-09 37.6 1.7 2.4 2 0 0 2 2 2 2 LIM domain DUF1974 PF09317.11 EMD62308.1 - 0.039 13.5 0.2 2.9 7.4 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF1974) ABC_tran_CTD PF16326.5 EMD62308.1 - 0.042 14.1 10.3 0.16 12.3 4.1 2.9 2 0 0 2 2 2 0 ABC transporter C-terminal domain Seryl_tRNA_N PF02403.22 EMD62308.1 - 0.38 11.0 11.6 2.2 8.6 2.7 3.0 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Desulfoferrod_N PF06397.12 EMD62308.1 - 0.4 10.4 12.3 9.5 5.9 1.9 3.6 2 1 1 3 3 3 0 Desulfoferrodoxin, N-terminal domain DUF2757 PF10955.8 EMD62308.1 - 1.1 9.6 7.7 5.4 7.3 0.2 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2757) Spc7 PF08317.11 EMD62308.1 - 1.5 7.6 15.2 0.43 9.4 0.5 2.6 3 0 0 3 3 3 0 Spc7 kinetochore protein KLRAQ PF10205.9 EMD62308.1 - 1.6 9.1 9.7 0.91 9.8 0.1 3.5 2 1 1 3 3 3 0 Predicted coiled-coil domain-containing protein DUF3450 PF11932.8 EMD62308.1 - 2.8 7.2 9.0 2.6 7.3 0.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) DUF4140 PF13600.6 EMD62308.1 - 2.8 8.4 4.7 1.3 9.5 0.5 2.7 2 1 1 3 3 2 0 N-terminal domain of unknown function (DUF4140) HIP1_clath_bdg PF16515.5 EMD62308.1 - 3.2 8.4 12.2 5.3 7.7 6.2 2.9 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF5082 PF16888.5 EMD62308.1 - 4.9 7.4 12.3 6.4 7.1 3.0 3.2 1 1 0 2 2 2 0 Domain of unknown function (DUF5082) TBCA PF02970.16 EMD62308.1 - 5.1 7.5 9.0 2 8.8 5.0 2.4 2 0 0 2 2 2 0 Tubulin binding cofactor A zf-ribbon_3 PF13248.6 EMD62308.1 - 7 6.2 20.1 0.8 9.2 0.0 4.5 5 1 0 5 5 5 0 zinc-ribbon domain Zn-ribbon_8 PF09723.10 EMD62308.1 - 7 6.9 20.0 1.1 9.4 1.2 4.1 3 1 1 4 4 4 0 Zinc ribbon domain TMF_TATA_bd PF12325.8 EMD62308.1 - 7.7 6.8 13.6 2.5 8.3 0.7 2.9 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding ZapB PF06005.12 EMD62308.1 - 9.8 6.7 13.9 22 5.6 4.3 2.9 2 0 0 2 2 2 0 Cell division protein ZapB DrrA_P4M PF14860.6 EMD62308.1 - 9.9 6.1 7.3 18 5.3 3.3 2.5 1 1 1 2 2 2 0 DrrA phosphatidylinositol 4-phosphate binding domain DUF5353 PF17304.2 EMD62309.1 - 2.6e-31 107.2 2.7 3.3e-31 106.8 2.7 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5353) ETRAMP PF09716.10 EMD62309.1 - 0.079 13.0 1.4 0.2 11.7 0.1 2.0 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) DUF3801 PF12687.7 EMD62309.1 - 0.69 10.0 8.4 0.89 9.6 8.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3801) DUF4190 PF13828.6 EMD62309.1 - 0.79 9.5 6.5 1.2 8.9 6.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4190) DUF4366 PF14283.6 EMD62309.1 - 2 8.4 6.9 0.12 12.4 1.7 1.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4366) IMUP PF15761.5 EMD62309.1 - 2.4 8.9 9.9 3.4 8.4 9.9 1.2 1 0 0 1 1 1 0 Immortalisation up-regulated protein OAD_gamma PF04277.13 EMD62309.1 - 2.7 8.7 9.3 63 4.3 9.3 2.4 1 1 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain CHCH PF06747.13 EMD62310.1 - 8.5e-06 25.8 4.7 1.5e-05 25.0 4.7 1.5 1 0 0 1 1 1 1 CHCH domain PepSY_TM PF03929.16 EMD62310.1 - 0.11 12.2 0.6 0.19 11.4 0.0 1.6 2 0 0 2 2 2 0 PepSY-associated TM region SWIRM PF04433.17 EMD62311.1 - 9.6e-29 99.6 0.1 1.9e-28 98.6 0.1 1.5 1 0 0 1 1 1 1 SWIRM domain SWIRM-assoc_1 PF16495.5 EMD62311.1 - 1.4e-27 95.4 5.2 3e-27 94.4 5.2 1.6 1 0 0 1 1 1 1 SWIRM-associated region 1 Myb_DNA-binding PF00249.31 EMD62311.1 - 5.5e-12 45.7 0.7 1e-11 44.8 0.7 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EMD62311.1 - 2.3e-07 31.0 0.3 5.3e-07 29.8 0.3 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain SANT_DAMP1_like PF16282.5 EMD62311.1 - 0.0039 17.4 0.3 0.0099 16.1 0.3 1.6 1 0 0 1 1 1 1 SANT/Myb-like domain of DAMP1 Myb_DNA-bind_7 PF15963.5 EMD62311.1 - 0.0039 17.1 0.1 0.012 15.4 0.1 1.8 1 0 0 1 1 1 1 Myb DNA-binding like ETF PF01012.21 EMD62312.1 - 3.9e-44 150.7 1.3 7.6e-44 149.8 1.3 1.4 1 0 0 1 1 1 1 Electron transfer flavoprotein domain ETF_alpha PF00766.19 EMD62312.1 - 3e-33 113.7 0.1 7.4e-33 112.4 0.1 1.7 1 0 0 1 1 1 1 Electron transfer flavoprotein FAD-binding domain Ion_trans_2 PF07885.16 EMD62313.1 - 6.5e-27 93.3 19.4 4.2e-15 55.5 8.9 3.7 4 1 1 5 5 5 2 Ion channel Lig_chan PF00060.26 EMD62313.1 - 0.016 15.0 2.8 0.058 13.2 0.0 2.8 2 1 0 2 2 2 0 Ligand-gated ion channel ABC_membrane PF00664.23 EMD62314.1 - 9.3e-88 294.4 36.9 5.6e-46 157.4 12.2 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EMD62314.1 - 3.1e-63 212.4 0.1 3.1e-34 118.4 0.0 3.4 3 0 0 3 3 3 3 ABC transporter SMC_N PF02463.19 EMD62314.1 - 7.8e-16 58.2 2.5 5.7e-06 25.9 0.0 4.3 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 EMD62314.1 - 3.2e-09 37.2 0.7 0.00035 20.9 0.1 3.1 3 1 0 3 3 3 2 AAA domain AAA_29 PF13555.6 EMD62314.1 - 3e-07 30.1 1.3 0.0017 18.1 0.3 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_30 PF13604.6 EMD62314.1 - 3.3e-06 27.0 0.4 0.057 13.1 0.0 3.1 3 1 0 3 3 3 2 AAA domain AAA_21 PF13304.6 EMD62314.1 - 3.8e-06 26.9 0.4 0.91 9.3 0.0 3.7 3 1 1 4 4 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 EMD62314.1 - 5.5e-06 26.9 2.1 0.048 14.0 0.4 3.0 3 0 0 3 3 3 2 AAA ATPase domain ABC_ATPase PF09818.9 EMD62314.1 - 7.3e-06 25.0 0.1 0.46 9.2 0.0 3.2 3 0 0 3 3 3 2 Predicted ATPase of the ABC class RsgA_GTPase PF03193.16 EMD62314.1 - 9.2e-06 25.7 0.0 0.25 11.2 0.0 2.9 3 0 0 3 3 2 2 RsgA GTPase AAA_15 PF13175.6 EMD62314.1 - 7.1e-05 22.7 0.7 0.02 14.6 0.0 2.5 3 0 0 3 3 2 1 AAA ATPase domain AAA_23 PF13476.6 EMD62314.1 - 0.00017 22.1 3.7 0.012 16.2 0.1 3.3 3 0 0 3 3 3 1 AAA domain AAA_25 PF13481.6 EMD62314.1 - 0.0008 19.0 0.0 1.6 8.2 0.0 2.7 2 0 0 2 2 2 2 AAA domain Rad17 PF03215.15 EMD62314.1 - 0.0032 17.4 0.1 1.1 9.2 0.0 2.6 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_18 PF13238.6 EMD62314.1 - 0.012 16.2 0.3 11 6.6 0.0 2.9 3 0 0 3 3 2 0 AAA domain AAA_33 PF13671.6 EMD62314.1 - 0.014 15.5 0.0 3 8.0 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 EMD62314.1 - 0.015 15.3 0.1 5.4 7.0 0.0 2.8 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Zeta_toxin PF06414.12 EMD62314.1 - 0.015 14.6 0.2 1.2 8.4 0.0 3.1 3 0 0 3 3 3 0 Zeta toxin AAA_28 PF13521.6 EMD62314.1 - 0.016 15.4 0.6 1.3 9.3 0.1 2.6 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 EMD62314.1 - 0.023 14.8 0.0 2.9 8.0 0.0 2.7 2 0 0 2 2 2 0 50S ribosome-binding GTPase SbcCD_C PF13558.6 EMD62314.1 - 0.026 14.8 1.7 0.84 9.9 0.2 3.4 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit ATP_bind_1 PF03029.17 EMD62314.1 - 0.036 13.9 0.1 0.45 10.3 0.0 2.2 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein RNA_helicase PF00910.22 EMD62314.1 - 0.067 13.6 0.1 19 5.7 0.0 2.9 2 0 0 2 2 2 0 RNA helicase SRP54 PF00448.22 EMD62314.1 - 0.069 12.8 0.1 7.4 6.1 0.0 2.7 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain Dala_Dala_lig_N PF01820.21 EMD62314.1 - 0.072 13.6 0.0 2.9 8.4 0.0 2.6 2 0 0 2 2 2 0 D-ala D-ala ligase N-terminus AAA_10 PF12846.7 EMD62314.1 - 0.089 11.7 0.1 7.2 5.4 0.0 2.7 2 1 0 2 2 2 0 AAA-like domain DUF87 PF01935.17 EMD62314.1 - 0.11 12.5 4.2 6.8 6.7 0.1 3.2 2 1 0 2 2 2 0 Helicase HerA, central domain AAA_7 PF12775.7 EMD62314.1 - 0.12 11.9 0.6 16 4.9 0.0 2.7 3 0 0 3 3 3 0 P-loop containing dynein motor region AAA_14 PF13173.6 EMD62314.1 - 0.15 12.1 0.1 59 3.7 0.0 3.7 4 0 0 4 4 3 0 AAA domain PRK PF00485.18 EMD62314.1 - 0.16 11.7 0.1 17 5.1 0.0 2.3 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family AAA PF00004.29 EMD62314.1 - 0.19 12.1 7.5 10 6.5 0.1 4.2 3 1 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 EMD62314.1 - 0.23 11.1 0.9 14 5.4 0.2 2.5 2 0 0 2 2 2 0 AAA domain Myb_DNA-binding PF00249.31 EMD62316.1 - 4.4e-37 126.0 14.8 1.1e-15 57.5 0.7 3.3 3 0 0 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EMD62316.1 - 3.1e-28 97.8 6.2 7.1e-14 51.8 0.6 3.3 1 1 2 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 EMD62316.1 - 1.6e-05 24.7 0.3 0.0093 15.8 0.1 2.6 1 1 0 2 2 2 2 Myb DNA-binding like SANT_DAMP1_like PF16282.5 EMD62316.1 - 0.00023 21.3 0.6 0.27 11.5 0.0 2.5 1 1 1 2 2 2 2 SANT/Myb-like domain of DAMP1 MADF_DNA_bdg PF10545.9 EMD62316.1 - 0.0046 17.3 6.5 4.9 7.5 0.1 3.7 4 0 0 4 4 4 2 Alcohol dehydrogenase transcription factor Myb/SANT-like Spore_III_AB PF09548.10 EMD62316.1 - 0.034 14.3 0.8 1.2 9.2 0.3 2.1 1 1 1 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) rRNA_processing PF08524.11 EMD62317.1 - 0.36 10.9 32.6 0.15 12.1 27.9 2.3 2 1 0 2 2 2 0 rRNA processing DUF4210 PF13915.6 EMD62318.1 - 1.4e-31 108.8 0.1 3.8e-31 107.5 0.1 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4210) Chromosome_seg PF13889.6 EMD62318.1 - 4.7e-24 84.3 0.9 1.1e-23 83.2 0.9 1.6 1 0 0 1 1 1 1 Chromosome segregation during meiosis Rhodanese PF00581.20 EMD62318.1 - 3.8e-14 53.1 0.0 7.8e-14 52.1 0.0 1.5 1 0 0 1 1 1 1 Rhodanese-like domain BSP PF04450.12 EMD62319.1 - 3.2e-77 259.0 0.0 3.6e-77 258.8 0.0 1.0 1 0 0 1 1 1 1 Peptidase of plants and bacteria SprT-like PF10263.9 EMD62319.1 - 0.019 14.8 0.0 0.03 14.2 0.0 1.4 1 0 0 1 1 1 0 SprT-like family Peptidase_M91 PF14891.6 EMD62319.1 - 0.12 12.7 0.0 0.16 12.3 0.0 1.2 1 0 0 1 1 1 0 Effector protein HAD_2 PF13419.6 EMD62320.1 - 1.1e-11 45.2 0.1 1.5e-11 44.7 0.1 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EMD62320.1 - 2.2e-08 34.6 0.0 6.4e-08 33.1 0.0 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EMD62320.1 - 0.00079 19.4 0.0 0.0014 18.7 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like 5_nucleotid PF05761.14 EMD62320.1 - 0.022 13.7 0.0 1.1 8.1 0.1 2.1 1 1 1 2 2 2 0 5' nucleotidase family KH_1 PF00013.29 EMD62322.1 - 3.4e-32 110.1 0.3 2.5e-07 30.4 0.0 6.0 6 0 0 6 6 6 4 KH domain GYF PF02213.16 EMD62323.1 - 7.2e-17 60.8 0.1 1.5e-16 59.7 0.1 1.6 1 0 0 1 1 1 1 GYF domain GYF_2 PF14237.6 EMD62323.1 - 0.001 18.9 0.0 0.0034 17.2 0.0 2.0 1 0 0 1 1 1 1 GYF domain 2 Homeodomain PF00046.29 EMD62323.1 - 0.25 11.2 3.0 0.56 10.1 3.0 1.6 1 0 0 1 1 1 0 Homeodomain RTX PF02382.15 EMD62323.1 - 2.1 7.9 4.6 0.34 10.6 0.1 1.9 2 0 0 2 2 2 0 N-terminal domain in RTX protein MFS_1 PF07690.16 EMD62325.1 - 1.8e-32 112.6 27.5 1.8e-32 112.6 27.5 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily DivIC PF04977.15 EMD62325.1 - 0.13 12.1 0.0 0.28 11.0 0.0 1.5 1 0 0 1 1 1 0 Septum formation initiator SNARE_assoc PF09335.11 EMD62326.1 - 1.3e-18 67.6 9.4 1.3e-18 67.6 9.4 2.2 3 0 0 3 3 3 1 SNARE associated Golgi protein Phage_holin_3_6 PF07332.11 EMD62326.1 - 0.0039 17.2 9.6 0.13 12.3 0.8 2.7 3 0 0 3 3 3 2 Putative Actinobacterial Holin-X, holin superfamily III YrhC PF14143.6 EMD62326.1 - 0.035 14.2 0.5 0.13 12.4 0.5 2.0 1 0 0 1 1 1 0 YrhC-like protein DUF3169 PF11368.8 EMD62326.1 - 0.67 9.4 12.5 0.62 9.5 0.6 3.3 3 1 0 3 3 3 0 Protein of unknown function (DUF3169) DUF4328 PF14219.6 EMD62326.1 - 0.93 9.0 3.5 3 7.4 0.2 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF4328) GATase_4 PF13230.6 EMD62327.1 - 4e-11 42.3 0.1 2.1e-10 40.0 0.0 1.9 2 0 0 2 2 2 1 Glutamine amidotransferases class-II GATase_6 PF13522.6 EMD62327.1 - 1.5e-08 34.9 0.0 2.5e-08 34.2 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase domain AA_permease PF00324.21 EMD62329.1 - 2.9e-100 336.2 35.5 3.5e-100 335.9 35.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EMD62329.1 - 7.5e-25 87.6 37.9 9.5e-25 87.3 37.9 1.1 1 0 0 1 1 1 1 Amino acid permease DUF1772 PF08592.11 EMD62329.1 - 5.9 7.2 15.9 3.5 7.9 8.0 3.8 2 1 0 3 3 3 0 Domain of unknown function (DUF1772) YEATS PF03366.16 EMD62331.1 - 2.3e-11 43.5 0.3 3.5e-11 42.9 0.3 1.3 1 0 0 1 1 1 1 YEATS family zf-C3HC4_4 PF15227.6 EMD62331.1 - 1.7e-05 24.9 2.4 1.7e-05 24.9 2.4 1.9 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.6 EMD62331.1 - 1.8e-05 24.5 3.3 1.8e-05 24.5 3.3 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EMD62331.1 - 3.3e-05 23.8 2.9 3.3e-05 23.8 2.9 1.8 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EMD62331.1 - 6.6e-05 22.7 6.8 0.0031 17.3 3.4 2.2 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMD62331.1 - 8.8e-05 22.3 3.0 8.8e-05 22.3 3.0 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EMD62331.1 - 0.00063 20.0 9.4 0.0048 17.2 9.4 2.1 1 1 0 1 1 1 1 Ring finger domain zf-RING_10 PF16685.5 EMD62331.1 - 0.015 15.4 4.7 0.095 12.9 2.4 2.2 2 0 0 2 2 2 0 zinc RING finger of MSL2 zf-RING_5 PF14634.6 EMD62331.1 - 0.058 13.4 10.6 0.77 9.8 11.0 2.5 1 1 1 2 2 2 0 zinc-RING finger domain Prok-RING_4 PF14447.6 EMD62331.1 - 0.069 13.0 11.2 18 5.3 7.8 3.2 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 zf-piccolo PF05715.13 EMD62331.1 - 0.24 11.5 5.8 0.62 10.3 1.9 2.3 2 0 0 2 2 2 0 Piccolo Zn-finger zf-ANAPC11 PF12861.7 EMD62331.1 - 1.1 9.4 5.1 9.2 6.4 2.4 2.7 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 EMD62331.1 - 2.8 7.6 7.9 0.27 10.9 3.4 1.6 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type zf-rbx1 PF12678.7 EMD62331.1 - 6.3 7.2 10.1 31 4.9 5.7 2.8 2 1 0 2 2 2 0 RING-H2 zinc finger domain tRNA-synt_2_TM PF16995.5 EMD62332.1 - 0.042 13.5 0.6 0.059 13.0 0.6 1.2 1 0 0 1 1 1 0 Transmembrane region of lysyl-tRNA synthetase DUF4519 PF15012.6 EMD62332.1 - 0.068 13.4 0.1 0.15 12.3 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4519) Gram_pos_anchor PF00746.21 EMD62332.1 - 0.074 13.0 4.7 0.23 11.5 4.7 1.8 1 0 0 1 1 1 0 LPXTG cell wall anchor motif DUF5305 PF17231.2 EMD62332.1 - 0.12 11.7 0.0 0.2 11.0 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5305) ABC_membrane PF00664.23 EMD62333.1 - 1.3e-91 307.1 32.8 6.7e-47 160.4 16.5 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EMD62333.1 - 8.4e-67 223.9 0.0 5.8e-32 111.1 0.0 2.6 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EMD62333.1 - 6.3e-14 51.9 7.5 8.4e-06 25.4 0.0 4.2 2 2 1 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 EMD62333.1 - 1.7e-09 38.3 0.6 0.00045 20.6 0.1 2.7 2 0 0 2 2 2 2 AAA ATPase domain ABC_ATPase PF09818.9 EMD62333.1 - 2.7e-08 33.1 2.3 0.00069 18.5 0.0 2.8 4 0 0 4 4 4 2 Predicted ATPase of the ABC class RsgA_GTPase PF03193.16 EMD62333.1 - 2.8e-07 30.6 0.0 0.025 14.5 0.0 2.7 2 0 0 2 2 2 2 RsgA GTPase AAA_29 PF13555.6 EMD62333.1 - 5e-07 29.4 1.7 0.0059 16.3 0.5 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.6 EMD62333.1 - 8.3e-07 29.4 1.2 0.14 12.4 0.2 3.7 2 2 0 2 2 2 2 AAA domain AAA_21 PF13304.6 EMD62333.1 - 1.3e-06 28.5 0.0 0.37 10.6 0.0 4.0 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system Zeta_toxin PF06414.12 EMD62333.1 - 2.2e-05 23.9 0.0 0.0054 16.0 0.0 3.0 3 0 0 3 3 3 1 Zeta toxin SbcCD_C PF13558.6 EMD62333.1 - 8e-05 22.8 2.7 0.43 10.9 0.3 4.1 2 2 0 2 2 2 2 Putative exonuclease SbcCD, C subunit AAA_30 PF13604.6 EMD62333.1 - 0.00013 21.8 1.2 0.68 9.6 0.1 3.8 3 1 0 3 3 3 2 AAA domain AAA_15 PF13175.6 EMD62333.1 - 0.00015 21.6 0.0 0.41 10.3 0.0 2.3 2 0 0 2 2 2 2 AAA ATPase domain AAA_25 PF13481.6 EMD62333.1 - 0.00048 19.8 1.4 0.86 9.1 0.2 3.0 4 0 0 4 4 3 2 AAA domain AAA_28 PF13521.6 EMD62333.1 - 0.00049 20.4 0.0 0.081 13.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 EMD62333.1 - 0.0025 17.8 0.1 2.5 8.1 0.0 3.4 4 0 0 4 4 3 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 EMD62333.1 - 0.0034 17.5 0.1 3.2 7.9 0.1 2.8 2 1 0 2 2 2 1 AAA domain APS_kinase PF01583.20 EMD62333.1 - 0.0044 16.9 0.1 0.21 11.5 0.1 2.8 2 0 0 2 2 2 1 Adenylylsulphate kinase AAA_23 PF13476.6 EMD62333.1 - 0.0067 17.0 0.2 3.4 8.1 0.1 2.9 3 0 0 3 3 2 1 AAA domain G-alpha PF00503.20 EMD62333.1 - 0.0096 15.1 0.0 3.4 6.7 0.0 2.3 2 0 0 2 2 2 1 G-protein alpha subunit AAA_14 PF13173.6 EMD62333.1 - 0.011 15.8 0.2 5.4 7.1 0.0 4.0 5 0 0 5 5 4 0 AAA domain AAA PF00004.29 EMD62333.1 - 0.014 15.8 0.6 50 4.3 0.1 4.4 3 1 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 EMD62333.1 - 0.016 15.8 0.0 7.9 7.0 0.0 2.6 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 EMD62333.1 - 0.027 14.6 0.0 4.1 7.5 0.0 3.0 2 0 0 2 2 2 0 50S ribosome-binding GTPase ATP-synt_ab PF00006.25 EMD62333.1 - 0.031 13.9 0.1 1.3 8.6 0.1 2.8 2 1 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain YvrJ PF12841.7 EMD62333.1 - 0.044 13.3 0.0 0.097 12.2 0.0 1.6 1 0 0 1 1 1 0 YvrJ protein family RNA_helicase PF00910.22 EMD62333.1 - 0.049 14.0 0.0 5.6 7.4 0.0 3.0 2 0 0 2 2 2 0 RNA helicase NB-ARC PF00931.22 EMD62333.1 - 0.055 12.7 0.0 5.2 6.2 0.0 2.5 2 0 0 2 2 2 0 NB-ARC domain DUF87 PF01935.17 EMD62333.1 - 0.088 12.9 1.3 2.1 8.4 0.1 2.9 3 0 0 3 3 3 0 Helicase HerA, central domain AAA_7 PF12775.7 EMD62333.1 - 0.098 12.2 0.0 18 4.8 0.0 2.5 2 0 0 2 2 2 0 P-loop containing dynein motor region PRK PF00485.18 EMD62333.1 - 0.098 12.4 0.0 6 6.6 0.0 2.4 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family Ploopntkinase3 PF18751.1 EMD62333.1 - 0.11 12.3 0.2 13 5.7 0.0 2.9 3 0 0 3 3 3 0 P-loop Nucleotide Kinase3 Fungal_trans PF04082.18 EMD62334.1 - 9.3e-11 41.3 0.3 3e-10 39.6 0.3 1.8 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD62334.1 - 6.8e-08 32.5 14.2 1.4e-07 31.5 14.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF3328 PF11807.8 EMD62336.1 - 9.1e-56 189.1 0.7 1.1e-55 188.8 0.7 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) dsrm PF00035.26 EMD62337.1 - 1.1e-07 32.4 0.0 2.4e-07 31.3 0.0 1.6 1 0 0 1 1 1 1 Double-stranded RNA binding motif Ribonucleas_3_3 PF14622.6 EMD62337.1 - 0.0044 17.2 0.0 0.07 13.3 0.0 2.1 2 0 0 2 2 2 1 Ribonuclease-III-like Ribonuclease_3 PF00636.26 EMD62337.1 - 0.0073 16.9 0.0 0.026 15.1 0.0 2.0 1 1 0 1 1 1 1 Ribonuclease III domain PfkB PF00294.24 EMD62338.1 - 2.2e-10 40.3 0.0 2.8e-10 40.0 0.0 1.1 1 0 0 1 1 1 1 pfkB family carbohydrate kinase CAP_N PF01213.19 EMD62339.1 - 7.3e-106 354.2 0.0 7.3e-106 354.2 0.0 1.5 2 0 0 2 2 2 1 Adenylate cyclase associated (CAP) N terminal CAP_C PF08603.11 EMD62339.1 - 9.3e-61 204.0 1.2 1.3e-60 203.6 1.2 1.2 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal TBCC PF07986.12 EMD62339.1 - 0.017 14.8 3.1 0.031 14.0 1.4 1.9 1 1 1 2 2 2 0 Tubulin binding cofactor C Pkinase PF00069.25 EMD62340.1 - 2.4e-20 73.0 0.0 3.7e-20 72.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD62340.1 - 8.7e-15 54.7 0.0 1.7e-14 53.7 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Herpes_TAF50 PF03326.13 EMD62341.1 - 0.0033 16.2 1.4 0.01 14.5 1.4 1.7 1 1 0 1 1 1 1 Herpesvirus transcription activation factor (transactivator) Aminotran_5 PF00266.19 EMD62343.1 - 1.4e-18 67.0 0.0 3e-18 65.9 0.0 1.4 2 0 0 2 2 2 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 EMD62343.1 - 2.4e-05 23.7 0.0 3.3e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EMD62343.1 - 0.0078 14.8 0.0 0.011 14.2 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme IBV_3B PF03622.13 EMD62343.1 - 0.044 13.9 0.0 3.2 8.0 0.0 2.4 2 0 0 2 2 2 0 IBV 3B protein Eaf7 PF07904.13 EMD62345.1 - 1.4e-27 96.1 0.1 1.4e-27 96.1 0.1 2.1 2 0 0 2 2 2 1 Chromatin modification-related protein EAF7 DUF4746 PF15928.5 EMD62345.1 - 0.057 12.8 5.0 0.091 12.2 5.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) FAM176 PF14851.6 EMD62345.1 - 0.46 10.1 6.0 0.91 9.2 6.0 1.4 1 0 0 1 1 1 0 FAM176 family Astro_capsid_p PF12226.8 EMD62345.1 - 0.76 8.9 6.3 1.2 8.2 6.3 1.3 1 0 0 1 1 1 0 Turkey astrovirus capsid protein DDHD PF02862.17 EMD62345.1 - 3.2 7.8 7.2 25 4.9 7.2 2.0 1 1 0 1 1 1 0 DDHD domain PGA2 PF07543.12 EMD62345.1 - 7.8 6.5 11.2 14 5.7 11.2 1.4 1 0 0 1 1 1 0 Protein trafficking PGA2 GCP_C_terminal PF04130.13 EMD62346.1 - 1.2e-70 238.5 0.4 1.2e-70 238.5 0.4 2.0 2 0 0 2 2 2 1 Gamma tubulin complex component C-terminal GCP_N_terminal PF17681.1 EMD62346.1 - 1.4e-32 113.5 0.8 4.3e-32 112.0 0.1 1.9 2 0 0 2 2 2 1 Gamma tubulin complex component N-terminal DUF3658 PF12395.8 EMD62346.1 - 0.018 14.9 0.0 0.1 12.5 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function ABC_tran PF00005.27 EMD62347.1 - 9.9e-48 162.1 0.0 6.4e-24 85.0 0.0 3.4 2 1 0 2 2 2 2 ABC transporter 4HB PF17947.1 EMD62347.1 - 5.2e-26 90.5 0.0 1.7e-25 88.9 0.0 2.0 1 0 0 1 1 1 1 Four helical bundle domain SMC_N PF02463.19 EMD62347.1 - 4e-16 59.1 0.0 3.2e-06 26.7 0.0 3.7 2 1 1 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EMD62347.1 - 6.5e-16 59.0 0.0 0.0025 17.7 0.0 5.1 5 0 0 5 5 5 4 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 EMD62347.1 - 1.3e-10 42.1 0.1 0.00022 21.8 0.1 2.9 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.6 EMD62347.1 - 2.5e-08 33.5 0.0 0.0051 16.5 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EMD62347.1 - 1.6e-07 31.4 0.2 0.00023 21.1 0.0 2.9 3 0 0 3 3 2 1 RsgA GTPase AAA_28 PF13521.6 EMD62347.1 - 1.9e-07 31.5 0.0 0.01 16.1 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 EMD62347.1 - 5.6e-07 29.9 0.0 0.026 14.8 0.0 3.7 4 0 0 4 4 3 2 AAA domain PduV-EutP PF10662.9 EMD62347.1 - 4.3e-06 26.5 0.0 0.11 12.2 0.0 3.1 2 0 0 2 2 2 2 Ethanolamine utilisation - propanediol utilisation AAA PF00004.29 EMD62347.1 - 5.5e-06 26.8 0.1 0.16 12.4 0.1 4.2 4 1 0 4 4 3 1 ATPase family associated with various cellular activities (AAA) MMR_HSR1 PF01926.23 EMD62347.1 - 6.6e-06 26.2 0.0 0.0055 16.8 0.0 2.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_16 PF13191.6 EMD62347.1 - 2e-05 25.1 0.8 0.39 11.1 0.0 3.7 5 0 0 5 5 3 2 AAA ATPase domain AAA_18 PF13238.6 EMD62347.1 - 7.5e-05 23.3 0.1 0.58 10.7 0.0 2.9 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.22 EMD62347.1 - 0.00011 22.5 0.0 0.52 10.7 0.0 2.8 2 0 0 2 2 2 2 RNA helicase NACHT PF05729.12 EMD62347.1 - 0.00018 21.5 0.0 0.14 12.0 0.0 2.7 2 0 0 2 2 2 1 NACHT domain Dynamin_N PF00350.23 EMD62347.1 - 0.00028 21.0 0.0 0.0017 18.5 0.0 2.4 2 0 0 2 2 2 1 Dynamin family DUF87 PF01935.17 EMD62347.1 - 0.00033 20.8 0.5 0.14 12.2 0.1 2.9 3 0 0 3 3 2 1 Helicase HerA, central domain AAA_15 PF13175.6 EMD62347.1 - 0.00035 20.4 1.1 1.1 8.9 0.1 3.2 4 0 0 4 4 2 2 AAA ATPase domain AAA_33 PF13671.6 EMD62347.1 - 0.00038 20.7 0.0 0.95 9.6 0.0 3.2 3 0 0 3 3 2 1 AAA domain AAA_24 PF13479.6 EMD62347.1 - 0.00051 19.8 0.0 1.4 8.6 0.0 2.7 2 0 0 2 2 2 2 AAA domain MeaB PF03308.16 EMD62347.1 - 0.00062 18.8 0.2 0.29 10.1 0.1 2.5 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_13 PF13166.6 EMD62347.1 - 0.00066 18.5 3.5 0.59 8.7 0.0 3.9 4 0 0 4 4 4 1 AAA domain G-alpha PF00503.20 EMD62347.1 - 0.00068 18.9 0.9 0.97 8.5 0.0 2.7 3 0 0 3 3 2 2 G-protein alpha subunit AAA_14 PF13173.6 EMD62347.1 - 0.00074 19.6 0.0 1.1 9.3 0.0 3.2 3 0 0 3 3 2 1 AAA domain AAA_30 PF13604.6 EMD62347.1 - 0.00082 19.1 0.0 0.92 9.2 0.0 3.2 3 0 0 3 3 3 1 AAA domain Roc PF08477.13 EMD62347.1 - 0.0014 18.9 0.0 3.3 7.9 0.0 3.2 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase AAA_27 PF13514.6 EMD62347.1 - 0.0014 18.2 0.0 1 8.9 0.0 2.7 2 0 0 2 2 2 1 AAA domain cobW PF02492.19 EMD62347.1 - 0.0023 17.5 0.0 1.5 8.4 0.0 3.1 3 0 0 3 3 3 1 CobW/HypB/UreG, nucleotide-binding domain NB-ARC PF00931.22 EMD62347.1 - 0.0029 16.8 0.1 0.18 11.0 0.0 2.5 2 0 0 2 2 2 1 NB-ARC domain IstB_IS21 PF01695.17 EMD62347.1 - 0.0033 17.2 0.1 10 5.8 0.0 3.6 3 0 0 3 3 3 0 IstB-like ATP binding protein ATP-synt_ab PF00006.25 EMD62347.1 - 0.0044 16.7 0.0 1.8 8.2 0.0 2.4 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP_bind_1 PF03029.17 EMD62347.1 - 0.0045 16.8 0.0 3.5 7.3 0.0 2.7 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein ATPase_2 PF01637.18 EMD62347.1 - 0.0046 16.9 0.6 1.3 8.8 0.0 3.2 3 0 0 3 3 2 1 ATPase domain predominantly from Archaea T2SSE PF00437.20 EMD62347.1 - 0.0068 15.5 0.1 0.95 8.5 0.0 2.6 2 0 0 2 2 2 1 Type II/IV secretion system protein Adaptin_N PF01602.20 EMD62347.1 - 0.0079 14.8 3.7 0.052 12.1 2.3 2.4 1 1 2 3 3 3 1 Adaptin N terminal region SbcCD_C PF13558.6 EMD62347.1 - 0.0079 16.4 0.0 2 8.7 0.0 3.1 2 1 0 2 2 2 1 Putative exonuclease SbcCD, C subunit CLP1_P PF16575.5 EMD62347.1 - 0.0087 15.9 0.0 1.1 9.1 0.0 2.8 2 0 0 2 2 2 1 mRNA cleavage and polyadenylation factor CLP1 P-loop Rad17 PF03215.15 EMD62347.1 - 0.015 15.2 0.0 0.94 9.4 0.0 2.5 2 0 0 2 2 2 0 Rad17 P-loop domain TsaE PF02367.17 EMD62347.1 - 0.022 14.7 0.0 6.9 6.7 0.0 2.9 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE RuvB_N PF05496.12 EMD62347.1 - 0.023 14.4 0.3 18 5.0 0.0 3.5 3 0 0 3 3 3 0 Holliday junction DNA helicase RuvB P-loop domain PRK PF00485.18 EMD62347.1 - 0.026 14.3 0.0 2.2 8.0 0.0 2.7 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family AAA_7 PF12775.7 EMD62347.1 - 0.033 13.7 0.1 6.2 6.3 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region HEAT PF02985.22 EMD62347.1 - 0.034 14.4 1.9 13 6.3 0.0 4.1 4 0 0 4 4 2 0 HEAT repeat AAA_5 PF07728.14 EMD62347.1 - 0.035 14.1 0.0 13 5.7 0.0 3.4 4 0 0 4 4 2 0 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 EMD62347.1 - 0.036 13.6 0.0 2.4 7.7 0.0 2.9 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 EMD62347.1 - 0.046 13.1 0.0 5.6 6.3 0.0 3.0 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI NTPase_1 PF03266.15 EMD62347.1 - 0.053 13.4 0.1 11 5.9 0.0 2.8 2 0 0 2 2 2 0 NTPase Septin PF00735.18 EMD62347.1 - 0.061 12.6 0.1 3.8 6.7 0.0 2.6 3 0 0 3 3 2 0 Septin Arf PF00025.21 EMD62347.1 - 0.082 12.4 0.0 15 5.0 0.0 2.5 2 0 0 2 2 2 0 ADP-ribosylation factor family VHS PF00790.19 EMD62347.1 - 0.084 12.7 0.7 0.32 10.9 0.7 2.0 1 0 0 1 1 1 0 VHS domain Ploopntkinase3 PF18751.1 EMD62347.1 - 0.088 12.7 0.0 16 5.4 0.0 2.5 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 dNK PF01712.19 EMD62347.1 - 0.1 12.5 0.0 2.8 7.7 0.0 2.4 2 0 0 2 2 2 0 Deoxynucleoside kinase ParcG PF10274.9 EMD62347.1 - 0.13 12.3 1.9 2.8 8.0 0.3 2.9 2 1 1 3 3 2 0 Parkin co-regulated protein HEAT_2 PF13646.6 EMD62347.1 - 0.2 12.1 3.8 21 5.6 0.6 3.6 1 1 3 4 4 4 0 HEAT repeats HET PF06985.11 EMD62348.1 - 1.3e-28 100.2 0.0 2.3e-28 99.4 0.0 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) SMC_N PF02463.19 EMD62349.1 - 0.15 11.5 0.0 0.17 11.3 0.0 1.1 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain Rick_17kDa_Anti PF05433.15 EMD62350.1 - 2e-05 24.3 21.8 3.8e-05 23.5 21.8 1.4 1 0 0 1 1 1 1 Glycine zipper 2TM domain Gly-zipper_Omp PF13488.6 EMD62350.1 - 0.0028 17.6 13.4 0.0032 17.4 12.3 1.7 1 1 1 2 2 2 2 Glycine zipper Gly-zipper_YMGG PF13441.6 EMD62350.1 - 0.007 16.1 14.7 0.014 15.1 14.7 1.5 1 0 0 1 1 1 1 YMGG-like Gly-zipper DUF533 PF04391.12 EMD62350.1 - 0.032 13.8 0.6 0.061 12.9 0.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF533) ATPase_gene1 PF09527.10 EMD62350.1 - 1.7 8.8 7.7 2.4 8.4 7.7 1.2 1 0 0 1 1 1 0 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter Zip PF02535.22 EMD62350.1 - 2.1 7.5 19.4 0.18 11.0 14.8 1.5 2 0 0 2 2 2 0 ZIP Zinc transporter TPR_1 PF00515.28 EMD62351.1 - 5.9e-10 38.5 11.4 0.00027 20.6 0.0 6.3 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_8 PF13181.6 EMD62351.1 - 5.4e-09 35.6 3.4 0.0015 18.5 0.0 6.0 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_2 PF07719.17 EMD62351.1 - 1.1e-08 34.5 21.1 0.0002 21.2 0.0 7.4 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_9 PF13371.6 EMD62351.1 - 4.2e-06 26.8 1.8 4.2e-06 26.8 1.8 3.9 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_11 PF13414.6 EMD62351.1 - 4.2e-05 23.1 4.6 0.049 13.3 0.0 3.9 2 1 1 3 3 3 2 TPR repeat TPR_19 PF14559.6 EMD62351.1 - 0.00013 22.4 8.9 0.96 10.0 0.4 5.0 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_16 PF13432.6 EMD62351.1 - 0.00036 21.1 14.3 0.00077 20.1 2.3 5.4 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_14 PF13428.6 EMD62351.1 - 0.00074 20.1 23.1 0.036 14.9 0.4 6.4 5 2 2 7 7 7 2 Tetratricopeptide repeat TPR_7 PF13176.6 EMD62351.1 - 0.0025 17.7 7.3 5.3 7.3 0.1 5.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 EMD62351.1 - 0.013 15.9 3.9 3.1 8.4 0.0 4.5 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_12 PF13424.6 EMD62351.1 - 0.015 15.6 15.8 0.13 12.6 1.7 5.2 5 2 0 5 5 5 0 Tetratricopeptide repeat TPR_6 PF13174.6 EMD62351.1 - 3 8.7 6.8 1.9e+02 3.0 0.0 4.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_10 PF13374.6 EMD62351.1 - 4.2 7.4 13.7 28 4.7 0.0 5.7 6 0 0 6 6 6 0 Tetratricopeptide repeat Ycf4 PF02392.16 EMD62353.1 - 0.081 12.5 0.2 0.089 12.4 0.2 1.0 1 0 0 1 1 1 0 Ycf4 Cupin_1 PF00190.22 EMD62353.1 - 0.093 12.3 0.8 0.12 12.0 0.8 1.1 1 0 0 1 1 1 0 Cupin Filament PF00038.21 EMD62354.1 - 1.1e-07 31.7 195.3 0.004 16.8 13.0 9.5 1 1 8 9 9 9 7 Intermediate filament protein Pox_A_type_inc PF04508.12 EMD62354.1 - 2.8e-06 26.9 37.2 0.39 10.6 0.1 15.1 15 2 2 17 17 17 1 Viral A-type inclusion protein repeat CENP-F_leu_zip PF10473.9 EMD62354.1 - 3.3e-06 27.2 239.2 0.0034 17.4 16.2 12.5 1 1 12 13 13 13 4 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Fib_alpha PF08702.10 EMD62354.1 - 0.0017 18.6 7.4 0.0017 18.6 7.4 11.4 2 2 10 12 12 12 5 Fibrinogen alpha/beta chain family CALCOCO1 PF07888.11 EMD62354.1 - 0.0017 17.3 48.0 0.0017 17.3 48.0 6.0 1 1 4 5 5 4 1 Calcium binding and coiled-coil domain (CALCOCO1) like TSC22 PF01166.18 EMD62354.1 - 0.0018 18.5 0.2 0.0018 18.5 0.2 14.4 14 4 3 17 17 16 2 TSC-22/dip/bun family Tup_N PF08581.10 EMD62354.1 - 0.0025 18.1 3.8 0.0025 18.1 3.8 13.3 10 5 1 12 12 11 3 Tup N-terminal KASH_CCD PF14662.6 EMD62354.1 - 0.0075 16.1 19.7 0.0075 16.1 19.7 9.8 1 1 9 10 10 7 2 Coiled-coil region of CCDC155 or KASH DUF4200 PF13863.6 EMD62354.1 - 0.01 16.2 20.0 0.01 16.2 20.0 12.6 2 2 9 12 12 9 0 Domain of unknown function (DUF4200) Fez1 PF06818.15 EMD62354.1 - 0.77 10.2 207.4 0.046 14.2 22.4 10.1 1 1 8 9 9 8 0 Fez1 Golgin_A5 PF09787.9 EMD62354.1 - 1.1 8.6 195.7 0.048 13.1 11.9 9.5 1 1 11 12 12 12 0 Golgin subfamily A member 5 Spc7 PF08317.11 EMD62354.1 - 1.4 7.8 241.2 0.011 14.7 21.5 9.8 1 1 10 11 11 11 0 Spc7 kinetochore protein Shugoshin_N PF07558.11 EMD62354.1 - 1.8 8.5 16.7 2.8 7.9 0.1 7.1 8 0 0 8 8 8 0 Shugoshin N-terminal coiled-coil region zf-RING_2 PF13639.6 EMD62356.1 - 9.2e-15 54.7 18.3 1.2e-12 47.9 9.9 2.2 2 0 0 2 2 2 2 Ring finger domain zf-RING_11 PF17123.5 EMD62356.1 - 1.7e-11 43.6 5.7 4e-11 42.5 5.7 1.7 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 EMD62356.1 - 4.2e-09 36.1 19.5 6.9e-08 32.2 9.9 2.3 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EMD62356.1 - 5.2e-09 35.8 11.1 2.3e-06 27.4 5.2 2.2 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMD62356.1 - 9e-09 35.1 16.5 3.9e-06 26.6 8.9 2.3 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zinc_ribbon_9 PF14369.6 EMD62356.1 - 1.6e-06 28.2 9.0 5.8e-05 23.3 3.9 2.6 2 0 0 2 2 2 2 zinc-ribbon zf-RING_5 PF14634.6 EMD62356.1 - 5.2e-06 26.3 13.1 1.3e-05 25.0 6.3 2.3 2 0 0 2 2 2 1 zinc-RING finger domain zf-rbx1 PF12678.7 EMD62356.1 - 1.8e-05 24.9 9.7 1.8e-05 24.9 9.7 2.5 2 0 0 2 2 2 1 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 EMD62356.1 - 2.7e-05 23.9 12.7 0.0023 17.8 5.7 2.3 2 0 0 2 2 2 2 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 EMD62356.1 - 8.7e-05 22.5 11.9 0.00093 19.2 6.7 2.5 2 0 0 2 2 2 1 RING-type zinc-finger HypA PF01155.19 EMD62356.1 - 0.012 15.7 7.2 0.021 14.8 0.7 2.2 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-C3HC4_4 PF15227.6 EMD62356.1 - 0.031 14.4 12.8 0.16 12.1 1.3 2.6 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING DUF1272 PF06906.11 EMD62356.1 - 0.16 12.1 8.4 0.43 10.7 0.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1272) DZR PF12773.7 EMD62356.1 - 0.18 11.9 7.0 0.64 10.1 0.4 2.4 2 0 0 2 2 2 0 Double zinc ribbon zf-UDP PF14569.6 EMD62356.1 - 0.21 11.7 2.5 3.7 7.7 0.2 2.5 2 0 0 2 2 2 0 Zinc-binding RING-finger PhnA_Zn_Ribbon PF08274.12 EMD62356.1 - 0.22 11.5 9.3 1.7 8.7 0.5 3.2 3 0 0 3 3 3 0 PhnA Zinc-Ribbon zf-RING_4 PF14570.6 EMD62356.1 - 0.35 10.7 12.2 1.5 8.7 4.7 2.3 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain Baculo_RING PF05883.11 EMD62356.1 - 0.41 10.6 2.5 0.99 9.4 0.3 2.1 2 0 0 2 2 2 0 Baculovirus U-box/Ring-like domain Zn_ribbon_17 PF17120.5 EMD62356.1 - 0.42 10.3 18.1 0.31 10.7 8.3 2.2 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type zf-Di19 PF05605.12 EMD62356.1 - 0.71 10.2 7.8 14 6.1 0.1 3.2 3 0 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zf-ANAPC11 PF12861.7 EMD62356.1 - 1.7 8.7 10.5 0.11 12.6 4.6 1.9 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING-like PF08746.11 EMD62356.1 - 2.5 8.5 16.5 0.41 11.0 6.8 2.3 2 0 0 2 2 2 0 RING-like domain zinc-ribbons_6 PF07191.12 EMD62356.1 - 8.2 6.5 10.9 1.4 9.0 0.8 2.7 2 1 0 2 2 2 0 zinc-ribbons Fis1_TPR_C PF14853.6 EMD62357.1 - 1.7e-25 88.8 2.4 2.7e-25 88.2 2.4 1.3 1 0 0 1 1 1 1 Fis1 C-terminal tetratricopeptide repeat Fis1_TPR_N PF14852.6 EMD62357.1 - 6.5e-18 64.1 0.0 1.1e-17 63.4 0.0 1.4 1 0 0 1 1 1 1 Fis1 N-terminal tetratricopeptide repeat TPR_2 PF07719.17 EMD62357.1 - 0.00053 19.9 4.4 0.0011 18.9 4.4 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_6 PF13174.6 EMD62357.1 - 0.089 13.5 0.4 0.21 12.3 0.4 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_1 PF00515.28 EMD62357.1 - 0.29 11.0 4.9 0.6 10.0 4.9 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat Spc24 PF08286.11 EMD62358.1 - 1.3e-34 118.6 0.4 3.7e-33 113.9 0.0 2.1 1 1 1 2 2 2 1 Spc24 subunit of Ndc80 DUF3080 PF11279.8 EMD62358.1 - 0.012 14.9 0.4 0.022 14.0 0.4 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3080) DUF5082 PF16888.5 EMD62358.1 - 0.055 13.7 1.7 0.76 10.1 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) APG6_N PF17675.1 EMD62358.1 - 0.088 13.3 3.1 0.14 12.7 3.1 1.3 1 0 0 1 1 1 0 Apg6 coiled-coil region DUF167 PF02594.16 EMD62358.1 - 0.093 12.9 0.0 0.21 11.8 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised ACR, YggU family COG1872 DUF773 PF05600.12 EMD62358.1 - 0.12 11.1 2.6 0.25 10.0 2.3 1.6 1 1 1 2 2 2 0 CDK5 regulatory subunit-associated protein 3 DASH_Dam1 PF08653.10 EMD62358.1 - 0.45 10.3 2.3 0.99 9.3 0.6 2.3 2 1 0 2 2 2 0 DASH complex subunit Dam1 Solute_trans_a PF03619.16 EMD62360.1 - 9.9e-98 326.9 12.8 1.2e-97 326.6 12.8 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha Exo_endo_phos PF03372.23 EMD62363.1 - 1.9e-05 24.3 0.0 4.3e-05 23.2 0.0 1.6 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family MFS_1 PF07690.16 EMD62364.1 - 7.9e-38 130.3 25.6 1.2e-37 129.7 25.6 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF1673 PF07895.11 EMD62364.1 - 0.1 12.3 0.2 0.24 11.1 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1673) adh_short_C2 PF13561.6 EMD62365.1 - 5.1e-54 183.3 2.6 8.2e-54 182.6 2.6 1.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EMD62365.1 - 5.7e-53 179.3 2.2 7e-53 179.0 2.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EMD62365.1 - 1.2e-11 44.9 0.6 2.3e-11 43.9 0.5 1.6 2 0 0 2 2 2 1 KR domain Epimerase PF01370.21 EMD62365.1 - 7.1e-05 22.4 1.1 0.00033 20.2 0.8 2.1 1 1 1 2 2 2 1 NAD dependent epimerase/dehydratase family HHH_5 PF14520.6 EMD62365.1 - 0.023 15.3 1.0 0.12 12.9 0.3 2.4 2 1 1 3 3 3 0 Helix-hairpin-helix domain TcpA PF05946.12 EMD62365.1 - 0.038 14.1 0.2 0.08 13.1 0.2 1.6 1 1 0 1 1 1 0 Toxin-coregulated pilus subunit TcpA FTCD PF02971.14 EMD62365.1 - 0.05 13.6 0.1 0.083 12.9 0.1 1.4 1 0 0 1 1 1 0 Formiminotransferase domain DUF4371 PF14291.6 EMD62365.1 - 0.11 12.1 0.1 0.17 11.5 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4371) GDP_Man_Dehyd PF16363.5 EMD62365.1 - 0.12 11.7 0.3 0.38 10.1 0.0 1.8 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase DASH_Ask1 PF08655.10 EMD62366.1 - 1.9e-30 104.5 0.1 2.9e-30 103.9 0.1 1.3 1 0 0 1 1 1 1 DASH complex subunit Ask1 PI3_PI4_kinase PF00454.27 EMD62367.1 - 1.7e-41 142.7 0.0 2.4e-41 142.2 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FANCI_HD2 PF14680.6 EMD62367.1 - 0.25 10.5 0.0 0.47 9.7 0.0 1.3 1 0 0 1 1 1 0 FANCI helical domain 2 SNF2_N PF00176.23 EMD62368.1 - 1.4e-70 237.8 0.1 2.1e-70 237.2 0.1 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EMD62368.1 - 6.7e-11 42.5 0.0 2.3e-10 40.8 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EMD62368.1 - 0.00013 21.8 0.0 0.00033 20.5 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase zf-RING_5 PF14634.6 EMD62368.1 - 0.0025 17.7 1.2 0.0049 16.8 1.2 1.5 1 0 0 1 1 1 1 zinc-RING finger domain ResIII PF04851.15 EMD62368.1 - 0.0035 17.3 0.0 0.0084 16.1 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HIRAN PF08797.11 EMD62368.1 - 0.0072 16.2 0.0 0.018 14.9 0.0 1.7 1 0 0 1 1 1 1 HIRAN domain HET PF06985.11 EMD62369.1 - 2.8e-13 50.5 9.2 1.1e-10 42.1 1.2 2.7 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) Peptidase_S8 PF00082.22 EMD62370.1 - 5e-27 94.9 13.5 8.7e-27 94.2 13.5 1.4 1 1 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 EMD62370.1 - 1.7e-14 54.2 0.0 2.8e-14 53.5 0.0 1.3 1 0 0 1 1 1 1 Peptidase inhibitor I9 DUF1889 PF08986.10 EMD62370.1 - 0.054 13.9 0.6 6.4 7.2 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF1889) SesA PF17107.5 EMD62371.1 - 2.1e-14 53.7 0.4 2.3e-14 53.6 0.4 1.0 1 0 0 1 1 1 1 N-terminal domain on NACHT_NTPase and P-loop NTPases DUF3688 PF12461.8 EMD62372.1 - 0.08 11.4 0.0 0.11 10.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3688) Asp PF00026.23 EMD62373.1 - 1.5e-27 96.9 0.8 1.8e-27 96.6 0.8 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease Thiolase_N PF00108.23 EMD62374.1 - 4.5e-68 229.4 0.1 6.4e-68 228.9 0.1 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EMD62374.1 - 4.5e-41 139.4 1.3 7e-41 138.7 0.3 1.8 2 0 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 EMD62374.1 - 0.075 12.6 0.2 0.68 9.5 0.2 2.2 2 0 0 2 2 2 0 Beta-ketoacyl synthase, N-terminal domain DUF4589 PF15252.6 EMD62375.1 - 7.5 6.5 10.2 8.9 6.2 10.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4589) ApbA PF02558.16 EMD62378.1 - 5.1e-31 107.4 0.0 9.1e-31 106.6 0.0 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA ApbA_C PF08546.11 EMD62378.1 - 1.8e-27 96.0 0.0 2.7e-26 92.2 0.0 2.0 2 0 0 2 2 2 1 Ketopantoate reductase PanE/ApbA C terminal Sacchrp_dh_NADP PF03435.18 EMD62378.1 - 0.098 12.9 0.2 0.39 11.0 0.1 2.1 2 1 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain DAO PF01266.24 EMD62378.1 - 0.1 12.2 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase ThiF PF00899.21 EMD62378.1 - 0.12 11.7 0.4 0.17 11.2 0.4 1.2 1 0 0 1 1 1 0 ThiF family Yip1 PF04893.17 EMD62380.1 - 8.8e-12 45.1 15.6 1.8e-11 44.0 15.7 1.5 1 1 0 1 1 1 1 Yip1 domain YIF1 PF03878.15 EMD62380.1 - 0.21 11.1 4.1 0.37 10.3 4.1 1.4 1 1 0 1 1 1 0 YIF1 p53-inducible11 PF14936.6 EMD62380.1 - 0.38 10.8 2.3 0.61 10.1 2.3 1.3 1 0 0 1 1 1 0 Tumour protein p53-inducible protein 11 GATA PF00320.27 EMD62381.1 - 3.4e-14 52.1 4.1 6.6e-14 51.2 4.1 1.5 1 0 0 1 1 1 1 GATA zinc finger PAS_3 PF08447.12 EMD62381.1 - 3.6e-10 40.0 0.0 6.6e-10 39.1 0.0 1.4 1 0 0 1 1 1 1 PAS fold PAS_9 PF13426.7 EMD62381.1 - 9.4e-06 25.8 0.0 0.00011 22.4 0.0 2.2 2 0 0 2 2 2 1 PAS domain PAS_11 PF14598.6 EMD62381.1 - 3.1e-05 24.1 0.0 5.7e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 EMD62381.1 - 0.00011 22.1 0.1 0.002 18.1 0.0 2.3 2 0 0 2 2 2 1 PAS fold PAS_4 PF08448.10 EMD62381.1 - 0.0014 18.8 0.0 0.005 17.1 0.0 1.8 2 0 0 2 2 2 1 PAS fold Peptidase_S66C PF17676.1 EMD62381.1 - 0.069 13.7 0.0 0.14 12.7 0.0 1.4 1 0 0 1 1 1 0 LD-carboxypeptidase C-terminal domain HisKA PF00512.25 EMD62382.1 - 1.9e-07 31.0 0.8 2.2e-07 30.8 0.8 1.1 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain Phosphorylase PF00343.20 EMD62383.1 - 0 1063.1 0.0 0 1062.9 0.0 1.0 1 0 0 1 1 1 1 Carbohydrate phosphorylase UPF0121 PF03661.13 EMD62386.1 - 6.2e-30 104.4 4.8 8.3e-30 103.9 4.8 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0121) DUF212 PF02681.14 EMD62386.1 - 0.088 12.9 0.2 0.4 10.8 0.1 2.0 2 0 0 2 2 2 0 Divergent PAP2 family AC_N PF16214.5 EMD62386.1 - 0.18 10.9 1.3 2 7.5 0.4 2.1 2 0 0 2 2 2 0 Adenylyl cyclase N-terminal extracellular and transmembrane region Septin PF00735.18 EMD62387.1 - 2.3e-120 401.1 1.4 2.3e-120 401.1 1.4 1.8 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.23 EMD62387.1 - 4e-08 33.3 2.1 4.4e-08 33.2 0.0 2.1 2 1 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EMD62387.1 - 0.0002 20.9 7.3 0.0007 19.2 0.0 3.2 2 2 0 2 2 2 1 Elongation factor Tu GTP binding domain AIG1 PF04548.16 EMD62387.1 - 0.00042 19.7 0.1 0.00042 19.7 0.1 2.7 2 1 0 2 2 2 1 AIG1 family ABC_tran PF00005.27 EMD62387.1 - 0.00055 20.5 5.0 0.019 15.5 0.0 2.7 2 1 1 3 3 3 1 ABC transporter RsgA_GTPase PF03193.16 EMD62387.1 - 0.001 19.0 0.7 0.001 19.0 0.7 3.7 3 1 0 3 3 3 1 RsgA GTPase AAA_16 PF13191.6 EMD62387.1 - 0.0017 18.7 0.1 0.0051 17.2 0.0 1.8 2 0 0 2 2 2 1 AAA ATPase domain Roc PF08477.13 EMD62387.1 - 0.0025 18.0 0.0 0.0083 16.3 0.0 1.9 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EMD62387.1 - 0.0027 17.3 0.0 0.012 15.2 0.0 2.2 2 0 0 2 2 2 1 Ras family AAA_22 PF13401.6 EMD62387.1 - 0.0067 16.7 0.6 0.036 14.3 0.0 2.4 2 1 0 2 2 2 1 AAA domain AAA_29 PF13555.6 EMD62387.1 - 0.012 15.3 0.0 0.024 14.4 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_24 PF13479.6 EMD62387.1 - 0.013 15.3 0.0 0.049 13.4 0.0 2.1 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EMD62387.1 - 0.013 15.0 0.0 0.026 14.0 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region RNA_helicase PF00910.22 EMD62387.1 - 0.02 15.3 1.8 0.52 10.7 0.0 2.5 2 0 0 2 2 2 0 RNA helicase FtsK_SpoIIIE PF01580.18 EMD62387.1 - 0.035 13.5 0.0 0.11 11.8 0.0 1.8 1 0 0 1 1 1 0 FtsK/SpoIIIE family Dynamin_N PF00350.23 EMD62387.1 - 0.17 11.9 12.1 0.29 11.2 0.5 4.0 3 2 0 3 3 3 0 Dynamin family Exonuc_VII_L PF02601.15 EMD62387.1 - 0.57 9.7 9.1 1.1 8.8 9.1 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF4085 PF13315.6 EMD62387.1 - 1.6 8.3 12.3 0.2 11.2 2.1 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF4085) DUF3987 PF13148.6 EMD62387.1 - 1.7 7.5 0.0 1.7 7.5 0.0 2.5 2 1 0 2 2 1 0 Protein of unknown function (DUF3987) DUF87 PF01935.17 EMD62387.1 - 3.1 7.8 7.6 4.8 7.2 0.0 2.8 3 0 0 3 3 3 0 Helicase HerA, central domain ATP_bind_1 PF03029.17 EMD62387.1 - 3.3 7.4 7.1 9.3 5.9 0.1 3.3 2 1 0 3 3 3 0 Conserved hypothetical ATP binding protein Atg14 PF10186.9 EMD62387.1 - 4.1 6.4 12.0 6.3 5.8 12.0 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Exo70 PF03081.15 EMD62388.1 - 3.6e-91 306.0 0.1 7.4e-91 305.0 0.1 1.5 1 0 0 1 1 1 1 Exo70 exocyst complex subunit AAL_decarboxy PF03306.13 EMD62388.1 - 0.056 12.8 0.0 2.2 7.6 0.0 2.5 2 1 0 2 2 2 0 Alpha-acetolactate decarboxylase DUF2935 PF11155.8 EMD62388.1 - 0.27 11.6 1.2 2 8.7 0.1 2.9 4 0 0 4 4 4 0 Domain of unknown function (DUF2935) DUF4795 PF16043.5 EMD62388.1 - 0.5 9.9 4.8 0.6 9.7 0.7 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4795) NPV_P10 PF05531.12 EMD62388.1 - 1.5 9.3 6.5 9.2 6.8 0.1 4.6 6 0 0 6 6 6 0 Nucleopolyhedrovirus P10 protein Laminin_II PF06009.12 EMD62388.1 - 1.6 8.7 8.6 14 5.7 0.2 4.0 4 0 0 4 4 4 0 Laminin Domain II Mer2 PF09074.10 EMD62388.1 - 2.2 8.0 6.7 1.4 8.7 0.0 3.3 4 0 0 4 4 4 0 Mer2 CorA PF01544.18 EMD62389.1 - 1.3e-09 37.8 0.6 2.4e-09 36.9 0.6 1.4 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein PLA2_B PF01735.18 EMD62390.1 - 1.6e-26 92.8 0.0 2.2e-26 92.3 0.0 1.1 1 0 0 1 1 1 1 Lysophospholipase catalytic domain DSPc PF00782.20 EMD62392.1 - 8.5e-09 35.3 0.1 2.7e-08 33.7 0.1 1.8 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Init_tRNA_PT PF04179.12 EMD62392.1 - 0.0062 16.8 0.0 0.011 16.1 0.0 1.4 1 0 0 1 1 1 1 Rit1 DUSP-like domain Y_phosphatase PF00102.27 EMD62392.1 - 0.061 12.9 0.1 0.094 12.3 0.1 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase HU-CCDC81_bac_2 PF18175.1 EMD62392.1 - 0.17 11.8 0.0 0.36 10.7 0.0 1.5 1 0 0 1 1 1 0 CCDC81-like prokaryotic HU domain 2 Glyco_hydro_32C PF08244.12 EMD62393.1 - 1.9e-17 63.7 0.0 3.4e-17 62.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 C terminal Glyco_hydro_32N PF00251.20 EMD62393.1 - 1e-15 58.1 0.0 1.7e-15 57.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 N-terminal domain Cullin PF00888.22 EMD62394.1 - 3.1e-193 643.8 19.4 4.2e-193 643.3 19.4 1.2 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 EMD62394.1 - 1.5e-26 92.2 4.8 1.5e-26 92.2 4.8 2.3 2 0 0 2 2 2 1 Cullin protein neddylation domain WAC_Acf1_DNA_bd PF10537.9 EMD62394.1 - 0.23 12.0 4.3 0.22 12.1 0.4 3.1 4 0 0 4 4 4 0 ATP-utilising chromatin assembly and remodelling N-terminal Cupin_2 PF07883.11 EMD62395.1 - 1.7e-08 34.1 0.2 3.7e-08 33.0 0.2 1.5 1 0 0 1 1 1 1 Cupin domain Cupin_6 PF12852.7 EMD62395.1 - 3.9e-05 23.4 0.0 5.2e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 Cupin Cupin_1 PF00190.22 EMD62395.1 - 5.2e-05 22.9 0.0 8.8e-05 22.1 0.0 1.3 1 0 0 1 1 1 1 Cupin Cupin_3 PF05899.12 EMD62395.1 - 0.0045 16.6 0.1 0.007 16.0 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF861) AraC_binding PF02311.19 EMD62395.1 - 0.0092 15.9 0.0 0.014 15.3 0.0 1.3 1 0 0 1 1 1 1 AraC-like ligand binding domain Mit_KHE1 PF10173.9 EMD62396.1 - 1e-59 201.8 1.5 1e-59 201.8 1.5 2.2 2 1 0 2 2 2 1 Mitochondrial K+-H+ exchange-related Arm-DNA-bind_2 PF12167.8 EMD62396.1 - 0.16 11.9 0.1 8.5 6.4 0.0 2.9 2 1 0 2 2 2 0 Arm DNA-binding domain Caskin-tail PF16632.5 EMD62396.1 - 1.5 9.3 4.0 5.6 7.4 2.9 2.4 2 1 0 2 2 2 0 C-terminal region of Caskin MARVEL PF01284.23 EMD62397.1 - 1.7e-05 24.9 5.3 2.3e-05 24.4 5.3 1.2 1 0 0 1 1 1 1 Membrane-associating domain NST1 PF13945.6 EMD62397.1 - 0.0065 16.6 1.1 0.016 15.3 0.1 2.0 2 0 0 2 2 2 1 Salt tolerance down-regulator E2F_TDP PF02319.20 EMD62398.1 - 0.045 13.8 0.1 0.057 13.5 0.1 1.3 1 1 0 1 1 1 0 E2F/DP family winged-helix DNA-binding domain TatD_DNase PF01026.21 EMD62399.1 - 6.2e-30 104.4 0.0 1.1e-29 103.6 0.0 1.4 1 0 0 1 1 1 1 TatD related DNase F-box-like PF12937.7 EMD62400.1 - 6.8e-08 32.3 0.1 1.8e-07 30.9 0.0 1.7 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EMD62400.1 - 9.7e-07 28.5 0.0 2.7e-06 27.1 0.0 1.8 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 EMD62400.1 - 0.13 12.2 0.0 0.26 11.2 0.0 1.4 1 0 0 1 1 1 0 F-box G-alpha PF00503.20 EMD62404.1 - 8.6e-117 390.2 0.0 9.9e-117 390.0 0.0 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EMD62404.1 - 1.5e-15 57.1 1.7 7.9e-11 41.7 0.2 2.8 2 2 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EMD62404.1 - 3.6e-05 23.3 0.1 0.11 11.8 0.0 2.2 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.13 EMD62404.1 - 0.0018 18.5 0.2 0.49 10.6 0.1 2.4 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase MCM PF00493.23 EMD62404.1 - 0.093 11.8 0.0 0.17 11.0 0.0 1.3 1 0 0 1 1 1 0 MCM P-loop domain AAA_29 PF13555.6 EMD62404.1 - 0.12 12.2 0.0 0.23 11.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain TniB PF05621.11 EMD62404.1 - 0.13 11.7 0.1 0.22 10.9 0.1 1.3 1 0 0 1 1 1 0 Bacterial TniB protein Pkinase PF00069.25 EMD62405.1 - 1.3e-67 227.9 0.0 1.7e-67 227.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD62405.1 - 4.2e-32 111.5 0.0 5.2e-32 111.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EMD62405.1 - 1.1e-05 24.6 0.1 1.4e-05 24.2 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EMD62405.1 - 8.3e-05 22.0 0.1 0.00025 20.4 0.1 1.7 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EMD62405.1 - 0.00044 20.2 0.0 0.0012 18.8 0.0 1.7 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.6 EMD62405.1 - 0.0008 18.8 0.0 0.05 12.9 0.0 2.2 1 1 1 2 2 2 1 Kinase-like FTA2 PF13095.6 EMD62405.1 - 0.011 15.4 0.0 0.022 14.4 0.0 1.5 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 RIO1 PF01163.22 EMD62405.1 - 0.019 14.6 0.1 0.045 13.3 0.0 1.6 2 0 0 2 2 2 0 RIO1 family Avl9 PF09794.9 EMD62406.1 - 6.3e-141 469.5 0.0 9.3e-141 468.9 0.0 1.2 1 0 0 1 1 1 1 Transport protein Avl9 SPA PF08616.10 EMD62406.1 - 4.3e-08 33.1 0.0 0.00017 21.5 0.0 2.6 2 0 0 2 2 2 2 Stabilization of polarity axis DUF2347 PF09804.9 EMD62406.1 - 1.3e-05 24.9 7.0 0.0011 18.7 0.1 3.8 3 1 0 3 3 3 1 Uncharacterized conserved protein (DUF2347) DENN PF02141.21 EMD62406.1 - 0.013 15.5 0.7 0.12 12.3 0.2 2.6 2 1 1 3 3 3 0 DENN (AEX-3) domain TFIIA PF03153.13 EMD62406.1 - 0.024 14.7 17.3 0.034 14.2 17.3 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Epimerase PF01370.21 EMD62407.1 - 8.7e-22 77.7 0.0 1.2e-21 77.3 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EMD62407.1 - 1.2e-15 57.7 0.0 1.3e-14 54.3 0.0 2.0 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 EMD62407.1 - 4e-12 45.7 0.0 5.4e-12 45.3 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 EMD62407.1 - 2e-08 33.7 0.0 2.5e-08 33.4 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.12 EMD62407.1 - 1.6e-06 27.5 0.0 0.031 13.5 0.0 2.3 2 0 0 2 2 2 2 Male sterility protein KR PF08659.10 EMD62407.1 - 3e-05 24.0 0.0 0.00015 21.7 0.0 2.1 2 1 1 3 3 3 1 KR domain NAD_binding_10 PF13460.6 EMD62407.1 - 5.8e-05 23.1 0.0 0.00035 20.5 0.0 2.0 2 0 0 2 2 2 1 NAD(P)H-binding Ldh_1_N PF00056.23 EMD62407.1 - 0.00041 20.5 0.0 0.00066 19.8 0.0 1.4 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain NmrA PF05368.13 EMD62407.1 - 0.003 17.1 0.0 2.1 7.9 0.0 2.1 2 0 0 2 2 2 2 NmrA-like family Polysacc_synt_2 PF02719.15 EMD62407.1 - 0.16 11.0 0.0 0.96 8.5 0.0 1.9 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein COesterase PF00135.28 EMD62408.1 - 2e-90 304.1 0.0 1.2e-79 268.5 0.0 2.0 1 1 1 2 2 2 2 Carboxylesterase family Abhydrolase_3 PF07859.13 EMD62408.1 - 6.6e-10 39.2 0.0 2.2e-09 37.5 0.0 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold SMP_LBD PF17047.5 EMD62409.1 - 2.1e-24 86.0 0.2 3e-24 85.5 0.2 1.2 1 0 0 1 1 1 1 Synaptotagmin-like mitochondrial-lipid-binding domain C2 PF00168.30 EMD62409.1 - 2.7e-15 56.5 0.0 4e-11 43.1 0.0 2.4 2 0 0 2 2 2 2 C2 domain Peptidase_C2 PF00648.21 EMD62410.1 - 3.7e-64 216.6 0.7 1.8e-62 211.1 0.4 3.0 2 1 0 2 2 2 1 Calpain family cysteine protease RR_TM4-6 PF06459.12 EMD62410.1 - 1.1 9.0 18.4 2.1 8.1 18.4 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 tRNA-synt_1e PF01406.19 EMD62410.1 - 2.7 7.2 6.3 6 6.1 6.3 1.5 1 0 0 1 1 1 0 tRNA synthetases class I (C) catalytic domain Borrelia_P83 PF05262.11 EMD62410.1 - 3.2 6.1 24.5 5 5.5 24.5 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein TFIIF_alpha PF05793.12 EMD62410.1 - 4.3 5.8 31.9 6.2 5.3 31.9 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) C1_2 PF03107.16 EMD62411.1 - 0.00018 21.8 8.0 0.0002 21.6 8.0 1.1 1 0 0 1 1 1 1 C1 domain C1_1 PF00130.22 EMD62411.1 - 0.089 12.7 7.5 0.87 9.5 0.3 2.1 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) FYVE_2 PF02318.16 EMD62411.1 - 0.37 11.0 7.4 0.5 10.6 6.6 1.6 1 1 0 1 1 1 0 FYVE-type zinc finger zf-HIT PF04438.16 EMD62411.1 - 0.64 9.9 9.7 0.12 12.3 5.5 1.8 2 0 0 2 2 2 0 HIT zinc finger Pribosyltran_N PF13793.6 EMD62413.1 - 3.7e-42 142.9 0.0 5.6e-41 139.1 0.0 2.2 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 EMD62413.1 - 9.8e-33 113.7 0.1 3.3e-26 92.4 0.0 2.4 2 0 0 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 EMD62413.1 - 3.4e-06 26.6 0.1 0.0015 18.1 0.1 2.8 3 0 0 3 3 3 2 Phosphoribosyl transferase domain Peroxidase_2 PF01328.17 EMD62414.1 - 2.8e-44 151.9 0.0 4.8e-44 151.1 0.0 1.4 1 0 0 1 1 1 1 Peroxidase, family 2 SNF2_N PF00176.23 EMD62415.1 - 1.1e-62 211.8 0.0 1.1e-62 211.8 0.0 2.1 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EMD62415.1 - 9.4e-20 71.0 0.1 8.1e-19 68.0 0.0 2.6 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EMD62415.1 - 4.2e-09 36.6 2.1 1.4e-08 34.9 0.0 2.7 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 EMD62415.1 - 7.2e-09 35.2 3.1 1.5e-07 30.9 0.0 3.0 3 0 0 3 3 3 1 Class II histone deacetylase complex subunits 2 and 3 Acetyltransf_1 PF00583.25 EMD62415.1 - 8e-06 26.1 0.0 2e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EMD62415.1 - 0.0023 17.9 0.0 0.0058 16.6 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain AT_hook PF02178.19 EMD62415.1 - 0.0054 16.4 10.3 0.73 9.9 0.4 2.8 2 0 0 2 2 2 2 AT hook motif Acetyltransf_7 PF13508.7 EMD62415.1 - 0.037 14.4 0.0 0.086 13.3 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain ATG_C PF09333.11 EMD62416.1 - 0.0019 18.5 0.0 0.0073 16.6 0.0 2.0 2 0 0 2 2 2 1 Autophagy-related protein C terminal domain VGLL4 PF15245.6 EMD62416.1 - 0.0029 17.7 0.8 0.0029 17.7 0.8 1.7 2 0 0 2 2 2 1 Transcription cofactor vestigial-like protein 4 VPS13_C PF16909.5 EMD62416.1 - 0.23 11.2 0.2 0.65 9.7 0.2 1.8 1 0 0 1 1 1 0 Vacuolar-sorting-associated 13 protein C-terminal Haem_degrading PF03928.14 EMD62418.1 - 8.5e-30 103.2 0.7 9.8e-30 103.1 0.7 1.0 1 0 0 1 1 1 1 Haem-degrading PKD_channel PF08016.12 EMD62419.1 - 7.3e-09 34.8 23.5 8.2e-08 31.3 23.5 2.1 1 1 0 1 1 1 1 Polycystin cation channel Ion_trans PF00520.31 EMD62419.1 - 2.8e-07 30.0 26.6 4.2e-06 26.2 26.6 2.2 1 1 0 1 1 1 1 Ion transport protein EIF_2_alpha PF07541.12 EMD62420.1 - 2.1e-37 127.8 0.0 3.9e-37 126.9 0.0 1.5 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.23 EMD62420.1 - 1e-13 51.4 0.9 2e-13 50.5 0.9 1.5 1 0 0 1 1 1 1 S1 RNA binding domain PH_4 PF15404.6 EMD62422.1 - 2e-62 210.2 0.1 6.9e-62 208.5 0.0 2.0 2 0 0 2 2 2 1 Pleckstrin homology domain Spo7_2_N PF15407.6 EMD62422.1 - 4.7e-24 83.8 0.4 1.4e-23 82.3 0.4 1.9 1 0 0 1 1 1 1 Sporulation protein family 7 PH PF00169.29 EMD62422.1 - 2e-09 37.9 0.0 0.24 11.9 0.0 5.3 4 1 0 4 4 4 3 PH domain PH_6 PF15406.6 EMD62422.1 - 0.00037 20.8 0.1 0.065 13.5 0.1 3.0 2 0 0 2 2 2 1 Pleckstrin homology domain Spidroin_MaSp PF11260.8 EMD62422.1 - 0.19 12.1 0.3 0.46 10.8 0.3 1.6 1 0 0 1 1 1 0 Major ampullate spidroin 1 and 2 p450 PF00067.22 EMD62423.1 - 3.9e-55 187.4 0.0 5.1e-55 187.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Methyltransf_31 PF13847.6 EMD62424.1 - 1.4e-05 24.9 0.0 2.1e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMD62424.1 - 2.4e-05 25.0 0.0 4.2e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMD62424.1 - 0.0029 18.2 0.0 0.0055 17.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMD62424.1 - 0.07 13.9 0.0 0.12 13.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain p450 PF00067.22 EMD62425.1 - 5.1e-20 71.7 0.0 1.7e-11 43.6 0.0 2.1 2 0 0 2 2 2 2 Cytochrome P450 3Beta_HSD PF01073.19 EMD62426.1 - 4e-47 160.5 0.0 5.2e-47 160.2 0.0 1.0 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EMD62426.1 - 4.3e-28 98.4 0.0 5.6e-28 98.0 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 EMD62426.1 - 3.1e-16 59.3 0.1 1.1e-12 47.6 0.1 2.2 1 1 1 2 2 2 2 Male sterility protein GDP_Man_Dehyd PF16363.5 EMD62426.1 - 1.3e-14 54.3 0.3 2e-13 50.4 0.0 2.1 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 EMD62426.1 - 3.8e-10 39.3 0.0 5.4e-10 38.8 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 EMD62426.1 - 6.2e-06 25.6 0.4 0.00012 21.3 0.3 2.5 2 1 0 2 2 2 1 Polysaccharide biosynthesis protein NmrA PF05368.13 EMD62426.1 - 0.02 14.4 0.0 0.058 12.9 0.0 1.9 1 1 0 1 1 1 0 NmrA-like family DUF3678 PF12435.8 EMD62426.1 - 0.1 12.0 0.2 0.19 11.1 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3678) DUF4090 PF13319.6 EMD62427.1 - 0.11 12.7 0.0 0.22 11.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4090) Phage_holin_5_2 PF16079.5 EMD62427.1 - 3.5 8.0 10.1 2.1 8.8 2.1 3.4 3 1 0 3 3 3 0 Phage holin family Hol44, in holin superfamily V BTB PF00651.31 EMD62428.1 - 4.7e-06 26.8 0.0 9.1e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain Prok-JAB PF14464.6 EMD62428.1 - 0.23 11.2 0.0 0.23 11.2 0.0 2.0 2 0 0 2 2 2 0 Prokaryotic homologs of the JAB domain DDE_1 PF03184.19 EMD62431.1 - 1.2e-27 96.7 0.0 2.7e-27 95.5 0.0 1.6 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EMD62431.1 - 6.6e-08 32.5 0.2 3.7e-07 30.1 0.0 2.3 2 1 1 3 3 3 1 Tc5 transposase DNA-binding domain DDE_3 PF13358.6 EMD62431.1 - 0.011 15.5 0.0 0.044 13.6 0.0 1.9 2 0 0 2 2 2 0 DDE superfamily endonuclease HTH_psq PF05225.16 EMD62431.1 - 0.029 14.1 0.0 0.055 13.2 0.0 1.4 1 0 0 1 1 1 0 helix-turn-helix, Psq domain CFEM PF05730.11 EMD62432.1 - 6.3e-13 48.6 8.2 6.3e-13 48.6 8.2 1.7 2 0 0 2 2 2 1 CFEM domain DuoxA PF10204.9 EMD62432.1 - 0.0051 15.9 1.3 0.0051 15.9 1.3 2.2 2 0 0 2 2 2 1 Dual oxidase maturation factor LAL_C2 PF18603.1 EMD62435.1 - 0.05 13.8 0.1 0.11 12.6 0.1 1.5 1 0 0 1 1 1 0 L-amino acid ligase C-terminal domain 2 RabGAP-TBC PF00566.18 EMD62436.1 - 4.2e-26 92.0 0.0 5.5e-26 91.6 0.0 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain MMS1_N PF10433.9 EMD62437.1 - 1e-50 172.8 0.0 1.7e-50 172.1 0.0 1.4 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term zf-C2H2 PF00096.26 EMD62438.1 - 0.00068 20.0 7.3 0.027 14.9 1.2 2.4 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMD62438.1 - 0.038 14.8 6.3 1.7 9.7 0.5 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger OrsD PF12013.8 EMD62438.1 - 0.37 11.2 7.0 0.24 11.9 2.8 2.3 1 1 1 2 2 2 0 Orsellinic acid/F9775 biosynthesis cluster protein D HALZ PF02183.18 EMD62439.1 - 0.00048 20.3 1.1 0.0016 18.6 0.1 2.5 2 1 0 2 2 2 1 Homeobox associated leucine zipper Filament PF00038.21 EMD62439.1 - 0.013 15.1 8.5 0.016 14.8 8.5 1.2 1 0 0 1 1 1 0 Intermediate filament protein Fzo_mitofusin PF04799.13 EMD62439.1 - 0.026 14.1 6.7 0.64 9.5 0.7 2.1 1 1 1 2 2 2 0 fzo-like conserved region UPF0449 PF15136.6 EMD62439.1 - 0.47 11.0 7.7 2.5 8.6 0.2 2.4 2 1 0 2 2 2 0 Uncharacterised protein family UPF0449 COG2 PF06148.11 EMD62439.1 - 1.7 8.8 6.5 0.51 10.4 1.8 2.0 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 YabA PF06156.13 EMD62439.1 - 2.7 8.7 7.4 2.7 8.7 1.3 2.4 1 1 1 2 2 2 0 Initiation control protein YabA ALMT PF11744.8 EMD62439.1 - 3.1 6.5 8.0 3.5 6.4 8.0 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter PRKG1_interact PF15898.5 EMD62439.1 - 3.8 8.5 12.3 12 6.9 10.3 2.5 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain UPF0242 PF06785.11 EMD62439.1 - 5.5 7.1 10.3 3.2 7.8 6.0 1.9 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus YtxH PF12732.7 EMD62439.1 - 5.9 7.5 8.3 17 6.0 8.3 1.9 1 1 0 1 1 1 0 YtxH-like protein FlgN PF05130.12 EMD62440.1 - 0.00042 20.9 14.9 0.0065 17.0 1.1 3.1 1 1 2 3 3 3 2 FlgN protein DUF4246 PF14033.6 EMD62440.1 - 0.00064 19.0 2.2 0.00072 18.8 2.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF4246) Sp38 PF07354.12 EMD62440.1 - 0.028 13.9 0.7 0.038 13.4 0.7 1.2 1 0 0 1 1 1 0 Zona-pellucida-binding protein (Sp38) ING PF12998.7 EMD62440.1 - 0.076 13.6 11.6 0.055 14.1 7.9 2.3 1 1 2 3 3 3 0 Inhibitor of growth proteins N-terminal histone-binding YlqD PF11068.8 EMD62440.1 - 0.09 13.2 17.0 0.3 11.4 9.6 2.4 1 1 1 2 2 2 0 YlqD protein Fez1 PF06818.15 EMD62440.1 - 0.17 12.4 16.5 0.21 12.0 16.5 1.2 1 0 0 1 1 1 0 Fez1 DUF724 PF05266.14 EMD62440.1 - 0.38 10.6 17.9 0.03 14.1 11.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF724) DUF3492 PF11997.8 EMD62440.1 - 0.51 10.0 4.1 0.72 9.5 3.7 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3492) DUF2730 PF10805.8 EMD62440.1 - 1.1 9.4 7.0 1.2 9.3 3.5 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF2730) DUF948 PF06103.11 EMD62440.1 - 1.2 9.5 7.7 3.3 8.1 0.3 3.3 2 1 2 4 4 4 0 Bacterial protein of unknown function (DUF948) zf-C4pol PF14260.6 EMD62440.1 - 1.3 9.5 4.7 16 6.1 0.3 2.5 1 1 1 2 2 2 0 C4-type zinc-finger of DNA polymerase delta DUF2937 PF11157.8 EMD62440.1 - 1.6 8.4 8.2 0.47 10.2 4.2 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2937) FapA PF03961.13 EMD62440.1 - 1.9 7.0 11.2 0.71 8.4 8.3 1.7 1 1 1 2 2 2 0 Flagellar Assembly Protein A DUF1664 PF07889.12 EMD62440.1 - 2 8.4 11.4 3 7.9 0.3 2.8 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) DHR10 PF18595.1 EMD62440.1 - 2.9 8.0 28.1 6.7 6.8 15.9 2.5 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain PRKG1_interact PF15898.5 EMD62440.1 - 5 8.1 23.3 4.2 8.3 3.6 2.1 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain Syntaxin_2 PF14523.6 EMD62440.1 - 8.6 6.8 10.7 4.8 7.6 3.1 2.9 1 1 2 3 3 3 0 Syntaxin-like protein Ank_2 PF12796.7 EMD62441.1 - 6.4e-25 87.6 0.0 1e-14 54.8 0.0 2.0 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMD62441.1 - 7.4e-23 80.6 0.1 5.7e-13 49.1 0.0 2.2 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMD62441.1 - 9.6e-18 62.5 0.0 9e-07 28.7 0.0 3.1 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.6 EMD62441.1 - 3.1e-15 56.0 0.0 2.5e-08 34.0 0.0 2.2 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 EMD62441.1 - 2.4e-13 49.8 0.0 0.00042 20.6 0.0 3.1 3 0 0 3 3 3 3 Ankyrin repeat PPR_2 PF13041.6 EMD62442.1 - 1.2e-22 79.8 0.1 7.8e-06 26.0 0.0 6.5 6 1 1 7 7 7 3 PPR repeat family PPR PF01535.20 EMD62442.1 - 1.3e-17 62.7 0.3 0.013 15.7 0.1 8.2 8 0 0 8 8 8 4 PPR repeat PPR_3 PF13812.6 EMD62442.1 - 4.8e-08 33.0 0.1 0.44 10.7 0.0 5.2 3 2 2 5 5 5 3 Pentatricopeptide repeat domain PPR_long PF17177.4 EMD62442.1 - 3.1e-07 30.0 0.0 0.013 14.9 0.0 3.4 2 1 1 3 3 3 2 Pentacotripeptide-repeat region of PRORP TPR_14 PF13428.6 EMD62442.1 - 0.00087 19.9 12.9 41 5.4 0.1 8.7 11 0 0 11 11 8 0 Tetratricopeptide repeat PPR_1 PF12854.7 EMD62442.1 - 0.008 15.9 1.1 20 5.0 0.1 4.6 5 0 0 5 5 5 0 PPR repeat ATP13 PF12921.7 EMD62442.1 - 0.017 15.0 0.1 2.5 8.0 0.0 4.1 3 2 1 4 4 4 0 Mitochondrial ATPase expression TPR_19 PF14559.6 EMD62442.1 - 0.027 15.0 9.9 9.4 6.8 0.0 5.9 7 0 0 7 7 6 0 Tetratricopeptide repeat SPOB_a PF14689.6 EMD62442.1 - 0.054 13.2 0.6 0.44 10.3 0.2 2.7 2 0 0 2 2 2 0 Sensor_kinase_SpoOB-type, alpha-helical domain TPR_2 PF07719.17 EMD62442.1 - 0.12 12.5 1.3 30 5.1 0.0 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat BTAD PF03704.17 EMD62442.1 - 0.13 12.7 7.0 13 6.2 0.1 5.5 6 2 1 8 8 8 0 Bacterial transcriptional activator domain TPR_1 PF00515.28 EMD62442.1 - 0.67 9.9 3.9 18 5.4 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 EMD62442.1 - 0.95 10.2 3.1 1.3e+02 3.5 0.0 5.2 5 0 0 5 5 4 0 Tetratricopeptide repeat SRP68 PF16969.5 EMD62443.1 - 1.9e-186 621.4 12.0 2.1e-186 621.2 12.0 1.0 1 0 0 1 1 1 1 RNA-binding signal recognition particle 68 BRCC36_C PF18110.1 EMD62443.1 - 0.55 10.4 3.8 1.5 9.0 0.1 2.9 3 0 0 3 3 3 0 BRCC36 C-terminal helical domain GATA PF00320.27 EMD62444.1 - 5e-15 54.8 3.0 8.2e-15 54.1 3.0 1.4 1 0 0 1 1 1 1 GATA zinc finger Macoilin PF09726.9 EMD62444.1 - 0.01 14.4 4.9 0.014 14.0 4.9 1.1 1 0 0 1 1 1 0 Macoilin family TF_Zn_Ribbon PF08271.12 EMD62444.1 - 0.014 14.9 0.5 0.024 14.1 0.5 1.3 1 0 0 1 1 1 0 TFIIB zinc-binding EzrA PF06160.12 EMD62444.1 - 0.023 12.9 2.5 0.03 12.5 2.5 1.1 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA TPR_MLP1_2 PF07926.12 EMD62444.1 - 0.023 14.8 6.2 0.043 13.9 6.2 1.4 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein Nsp1_C PF05064.13 EMD62444.1 - 0.028 14.2 2.4 0.045 13.6 2.4 1.3 1 0 0 1 1 1 0 Nsp1-like C-terminal region DUF3552 PF12072.8 EMD62444.1 - 0.087 12.2 9.6 0.12 11.8 9.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) CASP_C PF08172.12 EMD62444.1 - 0.099 12.0 4.7 0.17 11.2 4.7 1.3 1 0 0 1 1 1 0 CASP C terminal DUF2387 PF09526.10 EMD62444.1 - 0.12 12.5 0.3 0.52 10.5 0.0 2.1 2 1 0 2 2 2 0 Probable metal-binding protein (DUF2387) Atg14 PF10186.9 EMD62444.1 - 0.17 10.9 6.7 0.36 9.9 6.7 1.5 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Pox_A_type_inc PF04508.12 EMD62444.1 - 0.24 11.3 5.9 20 5.2 0.0 3.4 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat ZapB PF06005.12 EMD62444.1 - 3.7 8.0 12.7 2.3 8.7 9.6 1.9 1 1 1 2 2 2 0 Cell division protein ZapB PRKG1_interact PF15898.5 EMD62444.1 - 4.1 8.4 11.8 13 6.8 11.9 1.7 1 1 0 1 1 1 0 cGMP-dependent protein kinase interacting domain JIP_LZII PF16471.5 EMD62444.1 - 6.8 6.9 10.7 41 4.4 10.7 2.0 1 1 0 1 1 1 0 JNK-interacting protein leucine zipper II Spc24 PF08286.11 EMD62444.1 - 9.6 6.5 9.6 11 6.4 7.2 1.9 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 ATP-synt_C PF00137.21 EMD62445.1 - 7.7e-13 48.6 9.6 7.7e-13 48.6 9.6 2.5 2 1 1 3 3 3 2 ATP synthase subunit C Cnd1 PF12717.7 EMD62446.1 - 0.00063 19.8 0.4 4.2 7.4 0.1 4.0 1 1 1 3 3 3 1 non-SMC mitotic condensation complex subunit 1 ELYS PF13934.6 EMD62446.1 - 0.0046 17.0 5.5 0.19 11.7 0.5 2.1 1 1 1 2 2 2 2 Nuclear pore complex assembly FCD PF07729.12 EMD62446.1 - 0.0075 16.7 30.0 1.3 9.4 0.1 6.0 3 2 3 6 6 6 1 FCD domain E2F_TDP PF02319.20 EMD62446.1 - 0.014 15.5 0.6 3.6 7.7 0.1 3.0 2 1 0 2 2 2 0 E2F/DP family winged-helix DNA-binding domain KIX_2 PF16987.5 EMD62446.1 - 0.035 14.1 6.6 6.8 6.8 0.1 4.9 3 2 3 6 6 6 0 KIX domain DUF3861 PF12977.7 EMD62446.1 - 0.065 13.4 7.2 6.5 7.0 0.0 4.7 3 2 2 5 5 5 0 Domain of Unknown Function with PDB structure (DUF3861) Reductase_C PF14759.6 EMD62446.1 - 0.11 13.0 13.1 8.5 7.0 0.4 4.9 2 2 3 5 5 5 0 Reductase C-terminal XPC-binding PF09280.11 EMD62446.1 - 0.12 12.2 8.5 17 5.2 0.2 5.5 5 1 1 6 6 6 0 XPC-binding domain RNA_pol_Rpb4 PF03874.16 EMD62446.1 - 0.16 12.3 0.4 1.3 9.4 0.0 2.6 2 2 0 2 2 2 0 RNA polymerase Rpb4 DUF5578 PF17741.1 EMD62446.1 - 0.19 11.2 5.1 13 5.1 0.3 4.0 1 1 2 4 4 4 0 Family of unknown function (DUF5578) Pex19 PF04614.12 EMD62446.1 - 0.34 10.7 12.1 13 5.4 8.9 2.6 1 1 1 2 2 2 0 Pex19 protein family BLUF PF04940.12 EMD62446.1 - 0.47 10.6 5.9 7.6 6.7 0.1 4.6 2 2 3 5 5 5 0 Sensors of blue-light using FAD TM_PBP2_N PF16296.5 EMD62446.1 - 0.52 10.5 3.4 25 5.1 0.1 3.4 2 2 1 4 4 4 0 N-terminal of TM subunit in PBP-dependent ABC transporters PelD_GGDEF PF16963.5 EMD62446.1 - 0.55 10.0 4.2 23 4.8 0.1 3.5 2 2 3 5 5 5 0 PelD GGDEF domain Phage-MuB_C PF09077.11 EMD62446.1 - 1.7 8.5 20.0 11 6.0 3.4 5.1 2 2 3 5 5 5 0 Mu B transposition protein, C terminal HRDC PF00570.23 EMD62446.1 - 2.8 8.0 6.8 13 5.9 0.0 4.2 5 0 0 5 5 5 0 HRDC domain TraH PF06122.11 EMD62446.1 - 3 7.0 10.3 0.22 10.8 2.7 2.0 2 0 0 2 2 2 0 Conjugative relaxosome accessory transposon protein TPR_17 PF13431.6 EMD62446.1 - 4.1 8.0 19.3 19 5.9 0.2 5.7 6 0 0 6 6 6 0 Tetratricopeptide repeat GET2 PF08690.10 EMD62446.1 - 4.1 7.0 13.1 7 6.2 3.9 2.0 1 1 1 2 2 2 0 GET complex subunit GET2 TPR_16 PF13432.6 EMD62446.1 - 7 7.4 40.8 9.1 7.0 9.2 5.5 3 2 0 4 4 4 0 Tetratricopeptide repeat Wzy_C_2 PF11846.8 EMD62446.1 - 7.6 6.4 15.5 0.053 13.5 3.4 2.7 2 1 1 3 3 3 0 Virulence factor membrane-bound polymerase, C-terminal MFS_1 PF07690.16 EMD62447.1 - 7.9e-37 127.0 39.1 7.9e-37 127.0 39.1 1.6 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EMD62447.1 - 1.4e-11 43.9 7.9 1.4e-11 43.9 7.9 2.4 3 0 0 3 3 3 1 Sugar (and other) transporter OATP PF03137.20 EMD62447.1 - 1.1 7.4 11.2 1.8 6.8 2.4 2.7 1 1 1 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family CPP1-like PF11833.8 EMD62447.1 - 7.6 6.1 11.3 11 5.6 0.1 3.9 2 1 2 4 4 4 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like GTP_EFTU PF00009.27 EMD62448.1 - 2.3e-34 118.7 0.0 2.3e-34 118.7 0.0 2.2 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 EMD62448.1 - 1.1e-17 64.1 0.1 3.2e-17 62.6 0.1 1.9 1 0 0 1 1 1 1 Translation-initiation factor 2 GTP_EFTU_D2 PF03144.25 EMD62448.1 - 4.4e-11 43.0 7.7 3.3e-10 40.2 0.0 4.0 4 0 0 4 4 4 1 Elongation factor Tu domain 2 GTP_EFTU_D4 PF14578.6 EMD62448.1 - 6.7e-10 38.7 0.1 2.2e-09 37.1 0.1 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 4 MMR_HSR1 PF01926.23 EMD62448.1 - 2.4e-07 30.8 0.4 7.4e-06 26.0 0.1 3.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase Roc PF08477.13 EMD62448.1 - 0.00057 20.1 0.0 0.0017 18.6 0.0 1.8 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase TrkA_C PF02080.21 EMD62448.1 - 0.00096 18.9 0.4 1.3 8.9 0.0 3.4 3 0 0 3 3 3 1 TrkA-C domain ATP_bind_1 PF03029.17 EMD62448.1 - 0.017 14.9 0.0 0.017 14.9 0.0 2.7 2 1 0 2 2 2 0 Conserved hypothetical ATP binding protein Chitin_synth_2 PF03142.15 EMD62449.1 - 3.9e-238 791.4 0.3 5e-238 791.0 0.3 1.1 1 0 0 1 1 1 1 Chitin synthase Myosin_head PF00063.21 EMD62449.1 - 9.3e-81 272.0 0.0 6.3e-80 269.2 0.0 2.0 1 1 0 1 1 1 1 Myosin head (motor domain) Cyt-b5 PF00173.28 EMD62449.1 - 3.8e-19 68.6 0.4 7.6e-14 51.6 0.0 3.4 2 1 0 2 2 2 2 Cytochrome b5-like Heme/Steroid binding domain DEK_C PF08766.11 EMD62449.1 - 1e-16 60.6 0.4 2.7e-16 59.2 0.4 1.8 1 0 0 1 1 1 1 DEK C terminal domain Glyco_trans_2_3 PF13632.6 EMD62449.1 - 1.4e-10 41.4 4.7 3.5e-10 40.1 4.7 1.7 1 0 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 EMD62449.1 - 1.9e-08 34.5 0.1 2.2e-07 31.0 0.1 2.3 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 EMD62449.1 - 0.0014 18.4 0.0 1.6 8.5 0.0 2.7 2 0 0 2 2 2 2 Glycosyl transferase family 2 RsgA_GTPase PF03193.16 EMD62449.1 - 0.032 14.1 0.0 0.11 12.5 0.0 1.8 1 0 0 1 1 1 0 RsgA GTPase AAA_22 PF13401.6 EMD62449.1 - 0.047 14.0 0.1 0.17 12.1 0.1 2.0 2 0 0 2 2 1 0 AAA domain AAA_16 PF13191.6 EMD62449.1 - 0.098 13.0 0.2 0.47 10.8 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain ABC_tran PF00005.27 EMD62449.1 - 0.17 12.4 0.0 0.51 10.9 0.0 1.8 1 0 0 1 1 1 0 ABC transporter Chitin_synth_2 PF03142.15 EMD62450.1 - 3.4e-232 771.7 0.1 4.8e-232 771.3 0.1 1.1 1 0 0 1 1 1 1 Chitin synthase DEK_C PF08766.11 EMD62450.1 - 3.6e-14 52.4 0.4 1.3e-13 50.6 0.3 2.0 2 0 0 2 2 2 1 DEK C terminal domain Glyco_trans_2_3 PF13632.6 EMD62450.1 - 3.3e-13 50.0 3.3 3.3e-13 50.0 3.3 1.9 2 0 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 EMD62450.1 - 5.6e-13 49.3 0.0 1.5e-12 47.9 0.0 1.7 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Cyt-b5 PF00173.28 EMD62450.1 - 1.3e-11 44.4 0.0 3.1e-07 30.4 0.0 3.0 2 1 0 2 2 2 2 Cytochrome b5-like Heme/Steroid binding domain Myosin_head PF00063.21 EMD62450.1 - 2.1e-06 26.3 0.0 3.7e-06 25.5 0.0 1.4 1 0 0 1 1 1 1 Myosin head (motor domain) Glycos_transf_2 PF00535.26 EMD62450.1 - 0.00028 20.7 0.0 0.027 14.3 0.0 2.6 2 0 0 2 2 2 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 EMD62450.1 - 0.00046 19.7 0.0 0.0013 18.2 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferase family 21 End3 PF12761.7 EMD62451.1 - 7.5e-72 241.7 0.2 9.6e-72 241.3 0.2 1.1 1 0 0 1 1 1 1 Actin cytoskeleton-regulatory complex protein END3 EF-hand_4 PF12763.7 EMD62451.1 - 4.5e-49 164.7 0.0 5.3e-48 161.3 0.1 2.3 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.32 EMD62451.1 - 9.4e-09 34.2 1.0 9.7e-08 31.0 0.2 2.6 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 EMD62451.1 - 1.5e-07 31.7 0.8 5.3e-07 30.0 0.1 2.3 3 0 0 3 3 2 1 EF-hand domain pair EF-hand_8 PF13833.6 EMD62451.1 - 5e-06 26.3 2.3 0.00025 20.8 0.1 2.7 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_6 PF13405.6 EMD62451.1 - 0.00035 20.3 0.3 0.00035 20.3 0.3 2.6 3 0 0 3 3 3 1 EF-hand domain EF-hand_5 PF13202.6 EMD62451.1 - 0.0019 17.6 0.8 0.0042 16.5 0.1 2.0 2 0 0 2 2 2 1 EF hand Med9 PF07544.13 EMD62451.1 - 0.043 13.9 0.1 0.043 13.9 0.1 2.8 2 1 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 TPR_MLP1_2 PF07926.12 EMD62451.1 - 0.046 13.8 5.7 0.2 11.7 0.1 2.3 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein RPW8 PF05659.11 EMD62451.1 - 0.081 12.6 0.7 0.25 11.0 0.0 1.9 2 0 0 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 Phage_GP20 PF06810.11 EMD62451.1 - 0.39 10.5 4.3 6.3 6.6 2.4 2.3 1 1 1 2 2 2 0 Phage minor structural protein GP20 Syntaxin-6_N PF09177.11 EMD62451.1 - 0.55 10.8 4.6 13 6.4 4.6 2.5 1 1 0 1 1 1 0 Syntaxin 6, N-terminal COG2 PF06148.11 EMD62451.1 - 1 9.5 5.2 3.2 7.8 0.3 2.3 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Swi5 PF07061.11 EMD62451.1 - 1.2 9.2 4.2 4.9 7.3 1.3 2.3 2 0 0 2 2 2 0 Swi5 DivIC PF04977.15 EMD62451.1 - 2.3 8.1 5.5 20 5.1 0.2 2.3 2 0 0 2 2 2 0 Septum formation initiator GTP-bdg_M PF16360.5 EMD62451.1 - 3.6 8.3 7.5 0.93 10.1 1.9 2.3 2 0 0 2 2 2 0 GTP-binding GTPase Middle Region TSC22 PF01166.18 EMD62451.1 - 6.3 7.2 11.2 11 6.4 0.8 3.0 3 0 0 3 3 3 0 TSC-22/dip/bun family Spc7 PF08317.11 EMD62451.1 - 8 5.2 8.0 30 3.3 7.6 1.8 1 1 0 1 1 1 0 Spc7 kinetochore protein DAO PF01266.24 EMD62452.1 - 4.1e-60 204.2 0.3 5.1e-60 203.9 0.3 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EMD62452.1 - 2.2e-05 23.9 0.2 0.11 11.7 0.1 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EMD62452.1 - 0.0004 20.6 0.2 0.00094 19.4 0.2 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EMD62452.1 - 0.014 14.7 0.0 0.51 9.5 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EMD62452.1 - 0.039 13.0 0.3 0.095 11.8 0.3 1.5 1 1 0 1 1 1 0 FAD binding domain Lycopene_cycl PF05834.12 EMD62452.1 - 0.081 12.0 0.0 0.53 9.3 0.1 1.9 2 0 0 2 2 2 0 Lycopene cyclase protein TrkA_N PF02254.18 EMD62452.1 - 0.17 12.1 0.0 0.44 10.8 0.0 1.7 1 0 0 1 1 1 0 TrkA-N domain NUDIX PF00293.28 EMD62453.1 - 1.9e-12 47.4 0.1 5.1e-12 46.0 0.1 1.7 2 0 0 2 2 2 1 NUDIX domain DUF3305 PF11749.8 EMD62453.1 - 0.048 13.8 0.0 0.089 12.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3305) Chitin_synth_2 PF03142.15 EMD62454.1 - 4.3e-27 94.9 1.6 1.5e-24 86.6 0.9 2.4 2 0 0 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.6 EMD62454.1 - 3e-16 59.9 1.7 3e-16 59.9 1.7 2.2 2 2 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 EMD62454.1 - 7e-12 45.7 0.0 1.1e-11 45.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 EMD62454.1 - 0.0035 17.2 0.0 3.2 7.5 0.0 2.5 2 0 0 2 2 2 2 Glycosyl transferase family 2 MIF4G PF02854.19 EMD62456.1 - 1e-57 195.2 0.1 5.4e-29 101.3 0.1 3.5 3 0 0 3 3 3 3 MIF4G domain Upf2 PF04050.14 EMD62456.1 - 1.8e-39 135.6 5.3 1.8e-39 135.6 5.3 3.5 4 0 0 4 4 4 1 Up-frameshift suppressor 2 His_Phos_2 PF00328.22 EMD62457.1 - 2.7e-22 79.6 0.0 3.3e-22 79.4 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) HTH_Tnp_Tc5 PF03221.16 EMD62458.1 - 1.4e-09 37.8 0.1 2.6e-09 37.0 0.1 1.5 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain Ribosomal_S13_N PF08069.12 EMD62458.1 - 0.011 15.8 0.0 0.016 15.3 0.0 1.3 1 0 0 1 1 1 0 Ribosomal S13/S15 N-terminal domain Drf_GBD PF06371.13 EMD62458.1 - 0.06 12.9 0.0 0.07 12.7 0.0 1.0 1 0 0 1 1 1 0 Diaphanous GTPase-binding Domain DUF2721 PF11026.8 EMD62458.1 - 0.084 12.8 0.8 0.11 12.4 0.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2721) DUF3400 PF11880.8 EMD62458.1 - 0.12 11.9 0.0 0.25 10.9 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3400) DUF1678 PF07913.11 EMD62459.1 - 0.013 15.3 0.0 0.02 14.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1678) TPK_catalytic PF04263.16 EMD62460.1 - 2.2e-32 111.6 0.0 2.9e-32 111.3 0.0 1.2 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, catalytic domain TPK_B1_binding PF04265.14 EMD62460.1 - 1.3e-17 63.2 0.0 2.3e-17 62.5 0.0 1.3 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, vitamin B1 binding domain DUF2064 PF09837.9 EMD62460.1 - 0.065 13.1 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2064) SKN1 PF03935.15 EMD62463.1 - 2e-221 735.8 2.6 2.3e-221 735.6 2.6 1.0 1 0 0 1 1 1 1 Beta-glucan synthesis-associated protein (SKN1) PATR PF12951.7 EMD62463.1 - 0.14 12.3 0.8 0.38 10.9 0.8 1.8 1 0 0 1 1 1 0 Passenger-associated-transport-repeat DUF3636 PF12331.8 EMD62464.1 - 1.2e-45 155.0 0.1 2.4e-45 154.0 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3636) LCD1 PF09798.9 EMD62464.1 - 1.2e-05 24.0 1.8 0.11 11.0 0.0 3.7 3 1 1 4 4 4 3 DNA damage checkpoint protein CTP_transf_1 PF01148.20 EMD62465.1 - 1.5e-81 274.1 23.0 2e-81 273.7 23.0 1.1 1 0 0 1 1 1 1 Cytidylyltransferase family PPR_2 PF13041.6 EMD62466.1 - 1.8e-22 79.2 0.7 0.00029 20.9 0.1 8.4 5 2 3 8 8 8 5 PPR repeat family PPR_3 PF13812.6 EMD62466.1 - 8.5e-12 45.0 0.0 0.58 10.3 0.0 6.7 7 0 0 7 7 7 3 Pentatricopeptide repeat domain PPR PF01535.20 EMD62466.1 - 1e-11 44.2 11.5 0.044 14.0 0.1 9.2 10 0 0 10 10 10 3 PPR repeat PPR_long PF17177.4 EMD62466.1 - 6.3e-09 35.5 0.3 0.00026 20.4 0.0 3.6 2 1 2 4 4 4 2 Pentacotripeptide-repeat region of PRORP TPR_14 PF13428.6 EMD62466.1 - 0.0002 21.9 1.1 2.3 9.2 0.0 4.9 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_7 PF13176.6 EMD62466.1 - 0.00034 20.5 0.9 0.42 10.7 0.1 3.6 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 EMD62466.1 - 0.0043 17.3 0.2 4.5 7.6 0.0 3.7 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.17 EMD62466.1 - 0.0057 16.7 0.4 9.9 6.6 0.0 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat PPR_1 PF12854.7 EMD62466.1 - 0.017 14.8 0.6 19 5.0 0.1 5.1 5 0 0 5 5 5 0 PPR repeat TPR_19 PF14559.6 EMD62466.1 - 0.02 15.4 0.3 7.8 7.1 0.2 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.6 EMD62466.1 - 0.062 13.5 0.3 13 6.3 0.0 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.28 EMD62466.1 - 0.15 12.0 1.1 12 5.9 0.1 2.9 3 0 0 3 3 2 0 Tetratricopeptide repeat Sugar_tr PF00083.24 EMD62467.1 - 1.1e-99 334.4 18.1 1.3e-99 334.2 18.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD62467.1 - 3.9e-23 81.9 21.7 3.9e-23 81.9 21.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily NmrA PF05368.13 EMD62469.1 - 2e-16 60.3 0.0 2.9e-16 59.7 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EMD62469.1 - 2.5e-13 50.3 0.0 6.2e-13 49.0 0.0 1.6 2 0 0 2 2 2 1 NAD(P)H-binding Epimerase PF01370.21 EMD62469.1 - 1.8e-06 27.6 0.0 3.1e-05 23.6 0.0 2.1 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family adh_short PF00106.25 EMD62469.1 - 0.0036 16.8 0.0 0.0072 15.8 0.0 1.5 1 0 0 1 1 1 1 short chain dehydrogenase RmlD_sub_bind PF04321.17 EMD62469.1 - 0.015 14.4 0.1 0.038 13.1 0.0 1.8 2 1 0 2 2 2 0 RmlD substrate binding domain DapB_N PF01113.20 EMD62469.1 - 0.11 12.7 0.0 0.23 11.6 0.0 1.5 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Semialdhyde_dh PF01118.24 EMD62469.1 - 0.12 12.8 0.0 0.31 11.5 0.0 1.7 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain 3Beta_HSD PF01073.19 EMD62469.1 - 0.13 11.3 0.0 0.19 10.7 0.0 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family bZIP_1 PF00170.21 EMD62470.1 - 1.3e-08 34.8 11.0 2.6e-08 33.8 11.0 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EMD62470.1 - 2.6e-05 24.2 11.9 2.6e-05 24.2 11.9 1.9 3 0 0 3 3 3 1 Basic region leucine zipper bZIP_Maf PF03131.17 EMD62470.1 - 0.0024 18.4 7.4 0.0058 17.1 7.4 1.6 1 0 0 1 1 1 1 bZIP Maf transcription factor Zn_clus PF00172.18 EMD62471.1 - 1.4e-07 31.5 7.4 3e-07 30.4 7.4 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EMD62471.1 - 1.2e-05 24.3 0.7 1.7e-05 23.8 0.7 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain 3A PF00803.18 EMD62471.1 - 0.14 11.5 0.0 0.19 11.0 0.0 1.2 1 0 0 1 1 1 0 3A/RNA2 movement protein family DSPc PF00782.20 EMD62472.1 - 3e-09 36.8 0.0 5.5e-09 35.9 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EMD62472.1 - 0.0003 20.4 0.0 0.001 18.7 0.0 1.8 2 0 0 2 2 2 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 EMD62472.1 - 0.0043 17.2 0.0 0.021 15.0 0.0 2.0 1 1 1 2 2 2 1 Inositol hexakisphosphate PTEN_C2 PF10409.9 EMD62472.1 - 0.019 14.7 0.0 0.034 13.9 0.0 1.3 1 0 0 1 1 1 0 C2 domain of PTEN tumour-suppressor protein Y_phosphatase3 PF13350.6 EMD62472.1 - 0.032 14.2 0.0 0.06 13.3 0.0 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family CDKN3 PF05706.12 EMD62472.1 - 0.033 13.9 0.0 0.059 13.0 0.0 1.4 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) AAA PF00004.29 EMD62473.1 - 6.5e-16 59.0 0.0 2.1e-15 57.3 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EMD62473.1 - 0.0031 17.5 0.0 0.0072 16.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EMD62473.1 - 0.01 16.2 2.3 0.012 16.0 0.1 2.1 2 1 1 3 3 3 0 AAA ATPase domain RuvB_N PF05496.12 EMD62473.1 - 0.033 13.9 0.0 0.06 13.1 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EMD62473.1 - 0.043 14.1 4.4 0.073 13.3 0.1 2.9 2 2 1 3 3 3 0 AAA domain AAA_18 PF13238.6 EMD62473.1 - 0.088 13.4 0.0 0.32 11.5 0.0 2.1 1 1 0 1 1 1 0 AAA domain Fungal_trans PF04082.18 EMD62474.1 - 6.3e-21 74.6 0.1 9.5e-21 74.0 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD62474.1 - 5.9e-08 32.7 10.2 1.2e-07 31.7 10.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Glyco_hydro_7 PF00840.20 EMD62476.1 - 3.7e-138 460.9 9.8 4.3e-138 460.7 9.8 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 7 AlaDh_PNT_N PF05222.15 EMD62478.1 - 5.2e-29 101.3 0.0 7.3e-29 100.8 0.0 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain AlaDh_PNT_C PF01262.21 EMD62478.1 - 7.4e-05 22.1 0.0 0.00019 20.8 0.0 1.5 1 1 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Sulfate_transp PF00916.20 EMD62479.1 - 5.8e-86 288.6 7.4 7.8e-86 288.2 7.4 1.1 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 EMD62479.1 - 1.9e-18 66.2 0.0 3.3e-18 65.4 0.0 1.4 1 0 0 1 1 1 1 STAS domain STAS_2 PF13466.6 EMD62479.1 - 1.3e-05 25.4 0.0 3.8e-05 24.0 0.0 1.9 1 0 0 1 1 1 1 STAS domain MFS_MOT1 PF16983.5 EMD62479.1 - 0.045 14.1 7.7 0.36 11.3 4.3 2.6 2 0 0 2 2 2 0 Molybdate transporter of MFS superfamily Sugar_tr PF00083.24 EMD62480.1 - 5.8e-40 137.5 21.7 3.9e-39 134.8 21.7 2.3 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD62480.1 - 7.9e-36 123.7 28.2 4.1e-30 104.9 8.7 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 EMD62480.1 - 0.058 11.7 5.7 2.1 6.5 5.7 2.2 1 1 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Glyco_hydro_61 PF03443.14 EMD62481.1 - 1.5e-57 194.9 0.1 1.8e-57 194.6 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 DAO PF01266.24 EMD62482.1 - 1.9e-31 110.0 0.2 2.3e-31 109.6 0.2 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EMD62482.1 - 0.0054 16.9 0.0 0.013 15.7 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 EMD62482.1 - 0.018 15.0 0.0 0.044 13.8 0.0 1.6 1 0 0 1 1 1 0 FAD-NAD(P)-binding Thi4 PF01946.17 EMD62482.1 - 0.045 13.0 0.0 0.078 12.2 0.0 1.3 1 0 0 1 1 1 0 Thi4 family Pyr_redox_2 PF07992.14 EMD62482.1 - 0.12 11.5 0.0 0.19 10.9 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Peptidase_M6 PF05547.11 EMD62484.1 - 1.5e-06 26.9 0.1 0.0023 16.4 0.5 2.1 2 0 0 2 2 2 2 Immune inhibitor A peptidase M6 La PF05383.17 EMD62485.1 - 1.3e-17 63.6 0.0 2.2e-17 62.9 0.0 1.4 1 0 0 1 1 1 1 La domain RRM_1 PF00076.22 EMD62485.1 - 1.2e-05 25.1 0.1 2.4e-05 24.0 0.1 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) S4 PF01479.25 EMD62486.1 - 1.7e-14 53.2 0.0 3.6e-14 52.2 0.0 1.6 1 0 0 1 1 1 1 S4 domain HBS1_N PF08938.10 EMD62486.1 - 0.063 13.6 1.2 1.9 8.9 0.1 2.4 2 0 0 2 2 2 0 HBS1 N-terminus MobB PF03205.14 EMD62486.1 - 0.1 12.5 0.1 0.19 11.6 0.1 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B DUF4404 PF14357.6 EMD62486.1 - 0.1 13.3 1.0 0.24 12.0 0.2 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4404) Taq-exonuc PF09281.10 EMD62486.1 - 0.46 10.5 3.9 0.36 10.8 0.2 2.4 2 1 0 2 2 2 0 Taq polymerase, exonuclease LSM PF01423.22 EMD62488.1 - 7.6e-15 54.4 0.0 9.8e-15 54.0 0.0 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EMD62488.1 - 0.00031 20.8 0.0 0.0004 20.5 0.0 1.2 1 0 0 1 1 1 1 Ataxin 2 SM domain DUF4023 PF13215.6 EMD62488.1 - 0.026 14.5 0.2 0.065 13.2 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF4023) MFS_1 PF07690.16 EMD62489.1 - 5.3e-35 121.0 26.0 6.4e-35 120.7 25.6 1.3 2 0 0 2 2 2 1 Major Facilitator Superfamily ADH_zinc_N PF00107.26 EMD62490.1 - 1.2e-19 70.5 0.5 1.9e-19 70.0 0.5 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EMD62490.1 - 1.8e-06 29.1 0.1 3.1e-06 28.3 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EMD62490.1 - 0.058 13.3 0.0 0.15 11.9 0.0 1.7 1 0 0 1 1 1 0 Alcohol dehydrogenase GroES-like domain adh_short PF00106.25 EMD62490.1 - 0.16 11.4 1.0 0.49 9.8 0.6 1.9 1 1 1 2 2 2 0 short chain dehydrogenase GFA PF04828.14 EMD62491.1 - 9.7e-13 48.3 1.2 2e-12 47.2 0.8 1.7 2 0 0 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme RRM_1 PF00076.22 EMD62492.1 - 2.7e-07 30.3 0.0 6e-07 29.2 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PWI PF01480.17 EMD62492.1 - 3.3e-06 27.3 0.5 4.1e-05 23.8 0.0 2.3 2 0 0 2 2 2 1 PWI domain RRM_3 PF08777.11 EMD62492.1 - 0.0019 18.2 0.3 0.0019 18.2 0.3 2.6 2 1 1 3 3 3 1 RNA binding motif Nup35_RRM_2 PF14605.6 EMD62492.1 - 0.0022 18.0 0.0 0.0058 16.6 0.0 1.8 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif Selenoprotein_S PF06936.11 EMD62492.1 - 0.0052 16.6 2.4 0.012 15.4 2.4 1.5 1 0 0 1 1 1 1 Selenoprotein S (SelS) PKcGMP_CC PF16808.5 EMD62492.1 - 0.0088 15.9 4.1 0.018 14.9 4.1 1.4 1 0 0 1 1 1 1 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF4283 PF14111.6 EMD62492.1 - 0.027 14.0 0.0 0.054 13.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4283) zf-CCCH PF00642.24 EMD62492.1 - 0.03 14.2 1.2 0.055 13.4 1.2 1.4 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Ntox1 PF15500.6 EMD62492.1 - 0.038 14.3 2.7 0.071 13.5 1.9 1.9 1 1 0 1 1 1 0 Putative RNase-like toxin, toxin_1 RRM_occluded PF16842.5 EMD62492.1 - 0.047 13.6 0.0 0.14 12.1 0.0 1.7 1 0 0 1 1 1 0 Occluded RNA-recognition motif AAA_23 PF13476.6 EMD62492.1 - 0.15 12.5 2.4 0.26 11.8 2.4 1.4 1 0 0 1 1 1 0 AAA domain Med30 PF11315.8 EMD62492.1 - 0.16 12.1 1.7 0.32 11.2 1.7 1.4 1 0 0 1 1 1 0 Mediator complex subunit 30 DUF4523 PF15023.6 EMD62492.1 - 0.22 11.3 0.0 0.42 10.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4523) GTP_EFTU PF00009.27 EMD62493.1 - 7.4e-67 224.7 0.3 1.1e-66 224.2 0.3 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 EMD62493.1 - 1.6e-33 115.0 0.0 4.5e-33 113.6 0.0 1.8 2 0 0 2 2 2 1 Elongation factor G, domain IV EFG_C PF00679.24 EMD62493.1 - 3.7e-21 74.9 0.0 4.1e-20 71.6 0.0 2.4 2 0 0 2 2 2 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 EMD62493.1 - 2.1e-13 50.4 0.0 1.3e-12 47.9 0.0 2.4 2 1 0 2 2 2 1 Elongation factor Tu domain 2 EFG_II PF14492.6 EMD62493.1 - 1.3e-10 41.2 0.0 3.2e-10 40.0 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II MMR_HSR1 PF01926.23 EMD62493.1 - 0.00026 21.0 0.2 0.00059 19.9 0.2 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase Cyclin_N PF00134.23 EMD62494.1 - 4.2e-10 39.5 0.3 3.5e-08 33.2 0.0 2.2 2 0 0 2 2 2 2 Cyclin, N-terminal domain PAS_3 PF08447.12 EMD62494.1 - 0.11 12.7 0.0 4.4 7.7 0.0 2.5 2 0 0 2 2 2 0 PAS fold p450 PF00067.22 EMD62495.1 - 1.7e-49 168.8 0.0 2.5e-49 168.3 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 MutL_C PF08676.11 EMD62497.1 - 8.1e-23 80.8 0.0 1.7e-22 79.8 0.0 1.5 1 0 0 1 1 1 1 MutL C terminal dimerisation domain DNA_mis_repair PF01119.19 EMD62497.1 - 1.2e-19 70.1 0.4 1.3e-18 66.8 0.1 2.5 2 0 0 2 2 2 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 EMD62497.1 - 7.5e-11 42.0 0.7 2e-10 40.6 0.0 2.0 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 EMD62497.1 - 2.7e-07 31.1 0.0 8.6e-07 29.5 0.0 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Deltaretro_Tax PF05599.11 EMD62497.1 - 0.067 13.7 0.0 0.22 12.1 0.0 1.9 1 0 0 1 1 1 0 Deltaretrovirus Tax protein Iso_dh PF00180.20 EMD62499.1 - 5.1e-100 335.0 0.0 6.3e-100 334.7 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Phage_30_3 PF08010.11 EMD62499.1 - 0.024 14.4 0.0 0.059 13.2 0.0 1.6 1 0 0 1 1 1 0 Bacteriophage protein GP30.3 HHH_2 PF12826.7 EMD62499.1 - 0.12 12.4 0.0 0.62 10.2 0.0 2.1 2 0 0 2 2 2 0 Helix-hairpin-helix motif Peptidase_S26 PF10502.9 EMD62500.1 - 1.1e-05 25.3 0.0 5.1e-05 23.1 0.0 2.0 1 1 0 1 1 1 1 Signal peptidase, peptidase S26 Peptidase_S24 PF00717.23 EMD62500.1 - 1.2e-05 25.2 0.5 4.6e-05 23.3 0.5 1.9 1 1 0 1 1 1 1 Peptidase S24-like Iso_dh PF00180.20 EMD62501.1 - 5.5e-64 216.5 0.0 6.5e-64 216.3 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase GLTP PF08718.11 EMD62502.1 - 5.4e-46 156.6 0.0 7.3e-46 156.1 0.0 1.2 1 0 0 1 1 1 1 Glycolipid transfer protein (GLTP) Methyltransf_32 PF13679.6 EMD62503.1 - 0.15 12.1 0.0 0.3 11.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Pirin PF02678.16 EMD62504.1 - 8.4e-28 96.5 0.5 1.4e-27 95.8 0.5 1.3 1 0 0 1 1 1 1 Pirin Pirin_C_2 PF17954.1 EMD62504.1 - 1.2e-05 25.4 0.0 4e-05 23.7 0.0 1.9 1 0 0 1 1 1 1 Quercetinase C-terminal cupin domain Cupin_2 PF07883.11 EMD62504.1 - 0.00035 20.2 1.8 0.0042 16.8 0.2 2.7 2 1 1 3 3 3 1 Cupin domain Apolipoprotein PF01442.18 EMD62506.1 - 0.0045 16.9 0.0 0.011 15.6 0.0 1.6 1 1 0 1 1 1 1 Apolipoprotein A1/A4/E domain Baculo_PEP_C PF04513.12 EMD62506.1 - 0.068 13.2 0.1 0.36 10.9 0.1 1.8 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF883 PF05957.13 EMD62506.1 - 0.091 13.4 4.2 0.24 12.0 3.5 2.0 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) ISG65-75 PF11727.8 EMD62506.1 - 0.11 11.7 0.3 0.13 11.4 0.3 1.1 1 0 0 1 1 1 0 Invariant surface glycoprotein Ferric_reduct PF01794.19 EMD62507.1 - 9.9e-21 74.2 16.9 1.2e-20 73.9 7.6 3.5 3 1 0 3 3 3 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 EMD62507.1 - 8.1e-11 42.0 0.1 2.2e-10 40.6 0.1 1.7 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.12 EMD62507.1 - 2.5e-10 40.7 0.0 1.3e-08 35.1 0.0 2.2 1 1 0 1 1 1 1 Ferric reductase NAD binding domain NAD_binding_1 PF00175.21 EMD62507.1 - 0.029 15.0 0.0 0.057 14.1 0.0 1.5 1 0 0 1 1 1 0 Oxidoreductase NAD-binding domain DUF2615 PF11027.8 EMD62507.1 - 0.16 12.1 0.8 7 6.8 0.0 3.4 3 1 0 3 3 3 0 Protein of unknown function (DUF2615) DUF4381 PF14316.6 EMD62507.1 - 0.2 11.9 0.4 0.51 10.6 0.4 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) FA_hydroxylase PF04116.13 EMD62508.1 - 6e-26 91.4 22.5 1.3e-25 90.2 21.5 1.9 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily GMC_oxred_N PF00732.19 EMD62510.1 - 7.1e-44 150.4 0.0 9.9e-44 149.9 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EMD62510.1 - 7.5e-38 130.3 0.0 1.2e-37 129.6 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase DAO PF01266.24 EMD62510.1 - 5.5e-06 26.2 0.2 1.8e-05 24.5 0.2 1.8 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EMD62510.1 - 0.0076 15.5 0.5 2.1 7.5 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EMD62510.1 - 0.0083 15.3 0.8 0.84 8.7 0.8 2.2 2 0 0 2 2 2 2 FAD binding domain Pyr_redox_2 PF07992.14 EMD62510.1 - 0.028 13.7 0.1 0.072 12.3 0.1 1.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EMD62510.1 - 0.11 11.6 0.1 0.17 10.9 0.1 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein Pyr_redox PF00070.27 EMD62510.1 - 0.23 12.1 0.9 0.49 11.0 0.9 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase EthD PF07110.11 EMD62511.1 - 5.1e-12 46.8 0.0 6.4e-12 46.5 0.0 1.1 1 0 0 1 1 1 1 EthD domain MmlI PF09448.10 EMD62511.1 - 0.032 14.7 0.1 0.061 13.8 0.1 1.7 1 1 0 1 1 1 0 Methylmuconolactone methyl-isomerase Glyco_hydro_31 PF01055.26 EMD62513.1 - 1.8e-106 357.0 4.2 2.1e-106 356.7 4.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 EMD62513.1 - 6.4e-13 48.8 0.0 2.7e-12 46.8 0.0 2.1 2 0 0 2 2 2 1 Galactose mutarotase-like Melibiase PF02065.18 EMD62513.1 - 0.0027 16.7 0.6 0.0044 16.0 0.6 1.2 1 0 0 1 1 1 1 Melibiase Sugar_tr PF00083.24 EMD62514.1 - 6.4e-86 289.0 22.7 7.5e-86 288.8 22.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD62514.1 - 9.8e-26 90.5 27.3 1.7e-25 89.7 27.3 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 EMD62514.1 - 7.1e-06 24.7 2.2 7.1e-06 24.7 2.2 1.8 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) DUF3180 PF11377.8 EMD62514.1 - 0.042 14.0 4.3 1.3 9.1 1.3 3.4 1 1 2 3 3 3 0 Protein of unknown function (DUF3180) AAA PF00004.29 EMD62515.1 - 2.7e-11 44.0 0.0 6.1e-11 42.9 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 EMD62515.1 - 1.8e-06 28.0 0.1 3.8e-05 23.7 0.0 2.5 2 0 0 2 2 2 1 Rad17 P-loop domain RuvB_N PF05496.12 EMD62515.1 - 4.1e-05 23.4 0.0 7.6e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EMD62515.1 - 4.5e-05 23.7 0.0 0.00023 21.5 0.0 2.2 2 1 0 2 2 2 1 AAA domain AAA_5 PF07728.14 EMD62515.1 - 0.00013 21.9 0.0 0.00034 20.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EMD62515.1 - 0.0017 18.8 0.0 0.0093 16.4 0.0 2.1 1 1 0 2 2 1 1 AAA ATPase domain AAA_33 PF13671.6 EMD62515.1 - 0.0074 16.5 0.2 0.022 14.9 0.0 1.9 2 0 0 2 2 1 1 AAA domain NTPase_1 PF03266.15 EMD62515.1 - 0.012 15.5 0.2 0.03 14.2 0.2 1.6 1 0 0 1 1 1 0 NTPase RsgA_GTPase PF03193.16 EMD62515.1 - 0.016 15.1 0.4 0.037 13.9 0.0 1.8 2 0 0 2 2 2 0 RsgA GTPase AAA_14 PF13173.6 EMD62515.1 - 0.028 14.5 0.0 0.058 13.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 EMD62515.1 - 0.043 13.7 0.0 4.5 7.1 0.0 2.6 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_30 PF13604.6 EMD62515.1 - 0.061 13.0 2.7 0.21 11.3 0.1 2.7 3 0 0 3 3 3 0 AAA domain RFC1 PF08519.12 EMD62515.1 - 0.11 12.7 0.1 0.42 10.8 0.0 2.0 2 0 0 2 2 2 0 Replication factor RFC1 C terminal domain AAA_18 PF13238.6 EMD62515.1 - 0.11 13.0 0.1 0.32 11.5 0.1 1.8 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 EMD62515.1 - 0.13 12.0 0.0 0.26 11.0 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein TsaE PF02367.17 EMD62515.1 - 0.14 12.2 0.0 0.29 11.1 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_19 PF13245.6 EMD62515.1 - 0.15 12.4 0.0 0.7 10.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 EMD62515.1 - 0.78 10.3 4.0 1.4 9.4 0.0 3.1 3 0 0 3 3 3 0 ABC transporter adh_short PF00106.25 EMD62516.1 - 3.9e-24 85.2 0.0 1e-23 83.8 0.0 1.6 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD62516.1 - 7.3e-19 68.2 0.0 1.3e-18 67.4 0.0 1.4 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD62516.1 - 7.9e-10 38.9 0.0 1.1e-09 38.5 0.0 1.2 1 0 0 1 1 1 1 KR domain Alpha-amylase PF00128.24 EMD62517.1 - 2e-58 198.6 1.0 7.8e-57 193.3 1.0 2.1 1 1 0 1 1 1 1 Alpha amylase, catalytic domain CBM_20 PF00686.19 EMD62517.1 - 1.3e-29 102.0 0.4 2.9e-29 100.8 0.4 1.6 1 0 0 1 1 1 1 Starch binding domain DUF1966 PF09260.11 EMD62517.1 - 0.00067 19.9 0.2 0.0029 17.8 0.1 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF1966) GLEYA PF10528.9 EMD62517.1 - 0.067 13.6 9.2 0.19 12.2 0.1 3.9 4 0 0 4 4 4 0 GLEYA domain CBM_20 PF00686.19 EMD62518.1 - 1.1e-34 118.2 0.8 2.1e-34 117.3 0.8 1.5 1 0 0 1 1 1 1 Starch binding domain LPMO_10 PF03067.15 EMD62518.1 - 9e-10 39.5 2.6 9e-10 39.5 2.6 1.8 2 0 0 2 2 2 1 Lytic polysaccharide mono-oxygenase, cellulose-degrading Glyco_hydro_61 PF03443.14 EMD62518.1 - 8.7e-05 22.6 1.0 0.0014 18.6 0.0 2.6 3 0 0 3 3 3 1 Glycosyl hydrolase family 61 Peptidase_M14 PF00246.24 EMD62521.1 - 2.1e-71 241.1 0.1 8.2e-71 239.1 0.0 1.8 2 0 0 2 2 2 1 Zinc carboxypeptidase Ribosomal_60s PF00428.19 EMD62522.1 - 0.2 12.3 13.7 1 10.0 8.2 2.6 2 0 0 2 2 2 0 60s Acidic ribosomal protein Spt5_N PF11942.8 EMD62522.1 - 0.37 11.8 12.8 25 5.9 0.0 2.9 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal Sigma70_r1_1 PF03979.14 EMD62522.1 - 0.81 9.8 0.0 0.81 9.8 0.0 3.1 3 0 0 3 3 3 0 Sigma-70 factor, region 1.1 PBP1_TM PF14812.6 EMD62522.1 - 2.7 8.4 7.3 3.1 8.2 2.7 2.5 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DNA_pol_phi PF04931.13 EMD62522.1 - 4.5 5.3 14.5 6.1 4.8 14.5 1.1 1 0 0 1 1 1 0 DNA polymerase phi DUF4746 PF15928.5 EMD62522.1 - 8.2 5.7 13.9 1.1 8.6 6.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) Lectin_C PF00059.21 EMD62523.1 - 0.015 16.0 0.0 0.051 14.3 0.1 1.8 2 0 0 2 2 2 0 Lectin C-type domain Myb_DNA-binding PF00249.31 EMD62524.1 - 1.3e-23 82.9 3.9 2.4e-13 50.0 0.5 2.2 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EMD62524.1 - 5.5e-16 58.6 2.7 5.2e-12 45.8 0.2 2.4 1 1 1 2 2 2 2 Myb-like DNA-binding domain SLIDE PF09111.10 EMD62524.1 - 0.0074 16.3 0.0 0.015 15.3 0.0 1.5 1 0 0 1 1 1 1 SLIDE HTH_23 PF13384.6 EMD62524.1 - 0.05 13.4 0.1 0.1 12.4 0.1 1.4 1 0 0 1 1 1 0 Homeodomain-like domain DUF2774 PF11242.8 EMD62524.1 - 0.067 13.4 0.0 0.23 11.7 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2774) Sigma70_r4_2 PF08281.12 EMD62524.1 - 0.091 12.5 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 Sigma-70, region 4 Rrn6 PF10214.9 EMD62529.1 - 0.039 12.5 1.2 0.04 12.4 1.2 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor DUF2887 PF11103.8 EMD62529.1 - 0.13 12.3 0.9 0.18 11.8 0.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2887) CBP_BcsG PF11658.8 EMD62529.1 - 0.18 10.1 0.1 0.32 9.3 0.1 1.3 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG DUF2034 PF10356.9 EMD62530.1 - 1.3e-25 89.9 0.0 5.9e-15 55.2 0.0 2.2 1 1 1 2 2 2 2 Protein of unknown function (DUF2034) Mrr_cat PF04471.12 EMD62530.1 - 1.6e-07 31.3 0.0 2.8e-07 30.5 0.0 1.4 1 0 0 1 1 1 1 Restriction endonuclease Med21 PF11221.8 EMD62531.1 - 1.9e-39 135.2 7.2 2.1e-39 135.0 7.2 1.0 1 0 0 1 1 1 1 Subunit 21 of Mediator complex GOLGA2L5 PF15070.6 EMD62531.1 - 8e-05 21.5 5.0 9.9e-05 21.2 5.0 1.1 1 0 0 1 1 1 1 Putative golgin subfamily A member 2-like protein 5 ATG16 PF08614.11 EMD62531.1 - 0.00029 21.1 5.0 0.00044 20.5 5.0 1.3 1 1 0 1 1 1 1 Autophagy protein 16 (ATG16) DUF3450 PF11932.8 EMD62531.1 - 0.0025 17.2 7.0 0.16 11.2 1.8 2.0 2 0 0 2 2 2 2 Protein of unknown function (DUF3450) Med9 PF07544.13 EMD62531.1 - 0.011 15.8 8.2 0.064 13.3 5.5 2.9 2 1 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 K-box PF01486.17 EMD62531.1 - 0.013 15.6 4.1 3.1 8.1 1.8 2.4 2 0 0 2 2 2 0 K-box region BAR_3 PF16746.5 EMD62531.1 - 0.024 14.4 1.1 0.024 14.4 1.1 1.9 2 0 0 2 2 2 0 BAR domain of APPL family Herpes_UL6 PF01763.16 EMD62531.1 - 0.052 12.1 0.1 0.067 11.7 0.1 1.1 1 0 0 1 1 1 0 Herpesvirus UL6 like Mito_fiss_reg PF05308.11 EMD62531.1 - 0.063 13.4 4.3 0.077 13.1 4.3 1.2 1 0 0 1 1 1 0 Mitochondrial fission regulator GHL13 PF14883.6 EMD62531.1 - 0.091 11.8 0.1 0.12 11.4 0.1 1.2 1 0 0 1 1 1 0 Hypothetical glycosyl hydrolase family 13 TMPIT PF07851.13 EMD62531.1 - 0.092 12.0 0.8 0.14 11.4 0.8 1.2 1 0 0 1 1 1 0 TMPIT-like protein DUF1515 PF07439.11 EMD62531.1 - 0.11 12.6 2.0 0.14 12.2 0.8 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1515) Snapin_Pallidin PF14712.6 EMD62531.1 - 0.11 12.9 6.5 0.29 11.6 0.0 2.6 2 1 0 2 2 2 0 Snapin/Pallidin V-SNARE PF05008.15 EMD62531.1 - 0.32 11.4 5.7 5.9 7.3 0.1 3.0 2 2 0 2 2 2 0 Vesicle transport v-SNARE protein N-terminus DUF948 PF06103.11 EMD62531.1 - 0.34 11.2 3.1 18 5.7 0.4 3.0 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) PI3K_P85_iSH2 PF16454.5 EMD62531.1 - 0.53 9.9 8.7 0.73 9.4 8.7 1.4 1 1 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Syntaxin-6_N PF09177.11 EMD62531.1 - 0.68 10.5 5.0 10 6.7 5.0 2.5 1 1 0 1 1 1 0 Syntaxin 6, N-terminal Spore_III_AB PF09548.10 EMD62531.1 - 1.5 9.0 5.9 6 6.9 5.9 1.8 1 1 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) LidA_Long_CC PF18641.1 EMD62531.1 - 5.1 7.1 10.3 1.6 8.8 3.4 2.4 2 1 0 2 2 2 0 LidA long coiled-coil domain APG6_N PF17675.1 EMD62531.1 - 5.7 7.5 15.3 6.5 7.3 10.0 2.3 2 1 0 2 2 2 0 Apg6 coiled-coil region OmpH PF03938.14 EMD62531.1 - 6.9 7.0 13.1 1 9.7 7.0 2.0 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) DUF4355 PF14265.6 EMD62531.1 - 9.2 6.5 11.4 1 9.6 6.6 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4355) Serinc PF03348.15 EMD62533.1 - 3.4e-161 536.9 7.5 3.9e-161 536.8 7.5 1.0 1 0 0 1 1 1 1 Serine incorporator (Serinc) MFS_1 PF07690.16 EMD62534.1 - 9.1e-17 61.0 25.6 3.5e-16 59.1 23.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Nodulin-like PF06813.13 EMD62534.1 - 2.9e-15 56.5 6.0 6.2e-15 55.4 6.0 1.5 1 0 0 1 1 1 1 Nodulin-like CnrY PF17524.2 EMD62534.1 - 0.2 11.9 1.0 0.71 10.1 0.0 2.3 2 0 0 2 2 2 0 Anti-sigma factor CnrY DUF3391 PF11871.8 EMD62536.1 - 0.65 10.5 8.7 16 6.0 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3391) Ribosomal_60s PF00428.19 EMD62536.1 - 0.76 10.4 18.9 0.45 11.1 15.9 2.0 2 0 0 2 2 2 0 60s Acidic ribosomal protein CSRNP_N PF16019.5 EMD62536.1 - 4.3 7.2 7.4 0.43 10.5 2.3 1.9 2 0 0 2 2 2 0 Cysteine/serine-rich nuclear protein N-terminus SDA1 PF05285.12 EMD62536.1 - 5.7 6.3 16.2 0.77 9.1 10.9 1.9 2 0 0 2 2 2 0 SDA1 CPSF100_C PF13299.6 EMD62536.1 - 9.6 6.4 8.6 37 4.5 3.9 2.4 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Sec5 PF15469.6 EMD62537.1 - 4.3e-40 137.6 0.0 1.2e-39 136.1 0.0 1.8 1 0 0 1 1 1 1 Exocyst complex component Sec5 Vps51 PF08700.11 EMD62537.1 - 0.00051 20.1 0.0 0.0022 18.0 0.0 2.1 1 0 0 1 1 1 1 Vps51/Vps67 Mito_carr PF00153.27 EMD62538.1 - 4.7e-58 193.1 5.9 2.3e-19 69.1 2.0 3.8 3 1 0 3 3 3 3 Mitochondrial carrier protein zf-MYND PF01753.18 EMD62540.1 - 3.7e-10 39.7 15.7 6.1e-10 39.0 15.7 1.3 1 0 0 1 1 1 1 MYND finger Ank_2 PF12796.7 EMD62540.1 - 0.0012 19.4 0.0 0.0046 17.5 0.0 2.1 2 1 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EMD62540.1 - 0.0014 18.9 0.0 3.3 8.1 0.0 3.1 3 1 0 3 3 3 2 Ankyrin repeats (many copies) zf-C6H2 PF15801.5 EMD62540.1 - 0.036 14.4 11.9 0.071 13.4 11.9 1.4 1 0 0 1 1 1 0 zf-MYND-like zinc finger, mRNA-binding HP1451_C PF18472.1 EMD62540.1 - 0.13 12.2 0.0 0.3 11.1 0.0 1.6 1 0 0 1 1 1 0 HP1451 C-terminal domain adh_short_C2 PF13561.6 EMD62541.1 - 3.5e-58 196.9 5.8 4e-58 196.8 5.8 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EMD62541.1 - 2.3e-42 144.7 5.7 2.7e-42 144.4 5.7 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EMD62541.1 - 2.4e-06 27.6 2.4 3.2e-06 27.2 2.4 1.2 1 0 0 1 1 1 1 KR domain DUF1462 PF07315.11 EMD62541.1 - 0.033 14.4 0.0 0.079 13.3 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1462) RA PF00788.23 EMD62541.1 - 0.093 13.4 0.0 0.8 10.4 0.0 2.0 2 0 0 2 2 2 0 Ras association (RalGDS/AF-6) domain Cyclase PF04199.13 EMD62542.1 - 8e-17 61.8 0.0 1.1e-16 61.4 0.0 1.2 1 0 0 1 1 1 1 Putative cyclase Sugar_tr PF00083.24 EMD62543.1 - 1.7e-100 337.0 20.3 2e-100 336.8 20.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD62543.1 - 8.8e-31 107.1 33.4 3.5e-24 85.4 13.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Alpha-L-AF_C PF06964.12 EMD62544.1 - 2.8e-31 108.9 0.0 4.5e-31 108.2 0.0 1.3 1 0 0 1 1 1 1 Alpha-L-arabinofuranosidase C-terminal domain Glyco_hydro_44 PF12891.7 EMD62544.1 - 0.011 15.7 0.1 0.026 14.5 0.1 1.6 1 0 0 1 1 1 0 Glycoside hydrolase family 44 Sulfotransfer_4 PF17784.1 EMD62545.1 - 1.2e-58 198.5 0.0 2.5e-58 197.4 0.0 1.5 2 0 0 2 2 2 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 EMD62545.1 - 0.00011 22.7 1.8 0.023 15.1 0.1 2.5 1 1 1 2 2 2 2 Sulfotransferase family AAA_18 PF13238.6 EMD62545.1 - 0.047 14.2 0.0 0.085 13.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain Sulfotransfer_1 PF00685.27 EMD62545.1 - 0.071 12.6 0.0 0.098 12.1 0.0 1.3 1 0 0 1 1 1 0 Sulfotransferase domain SET PF00856.28 EMD62546.1 - 1.7e-13 51.3 1.5 4.6e-13 49.9 0.2 2.3 2 1 0 2 2 2 1 SET domain TPP_enzyme_N PF02776.18 EMD62547.1 - 1.6e-38 132.0 0.0 1.2e-37 129.2 0.0 2.1 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 EMD62547.1 - 8.9e-19 67.8 0.0 1.9e-18 66.7 0.0 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 EMD62547.1 - 1.1e-13 51.1 0.0 2.2e-13 50.1 0.0 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain Abhydrolase_1 PF00561.20 EMD62548.1 - 4.6e-22 78.9 0.0 3.2e-21 76.2 0.0 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_4 PF08386.10 EMD62548.1 - 1e-18 67.3 0.0 2.1e-18 66.3 0.0 1.5 1 0 0 1 1 1 1 TAP-like protein Hydrolase_4 PF12146.8 EMD62548.1 - 0.0025 17.1 0.0 1.5 8.0 0.0 2.4 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Ser_hydrolase PF06821.13 EMD62548.1 - 0.11 12.3 0.0 0.23 11.3 0.0 1.4 1 0 0 1 1 1 0 Serine hydrolase Lebercilin PF15619.6 EMD62549.1 - 0.0062 16.2 4.0 0.0072 16.0 2.4 1.9 1 1 0 1 1 1 1 Ciliary protein causing Leber congenital amaurosis disease TPR_MLP1_2 PF07926.12 EMD62549.1 - 0.0068 16.5 2.6 0.047 13.8 1.4 2.5 1 1 1 2 2 2 1 TPR/MLP1/MLP2-like protein HOOK PF05622.12 EMD62549.1 - 0.0082 14.4 5.1 0.0099 14.1 5.1 1.1 1 0 0 1 1 1 1 HOOK protein KASH_CCD PF14662.6 EMD62549.1 - 0.013 15.4 3.1 0.017 15.0 2.0 1.6 1 1 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH Spc7 PF08317.11 EMD62549.1 - 0.025 13.5 5.3 0.013 14.4 2.0 1.8 1 1 1 2 2 2 0 Spc7 kinetochore protein COMM_domain PF07258.14 EMD62549.1 - 0.028 14.6 2.9 1 9.5 0.2 3.0 2 2 1 3 3 3 0 COMM domain TACC_C PF05010.14 EMD62549.1 - 0.029 14.2 3.9 0.054 13.3 3.8 1.5 1 1 0 1 1 1 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Prefoldin_2 PF01920.20 EMD62549.1 - 0.029 14.3 3.8 0.12 12.3 0.6 2.6 1 1 0 2 2 2 0 Prefoldin subunit CENP-F_leu_zip PF10473.9 EMD62549.1 - 0.035 14.1 3.7 2 8.4 3.7 2.6 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF913 PF06025.12 EMD62549.1 - 0.039 12.9 1.5 0.058 12.4 1.5 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) BLOC1_2 PF10046.9 EMD62549.1 - 0.042 14.1 7.3 0.064 13.6 1.9 3.1 1 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Rop-like PF05082.13 EMD62549.1 - 0.06 13.2 1.4 0.5 10.2 0.2 2.6 2 1 1 3 3 2 0 Rop-like DUF948 PF06103.11 EMD62549.1 - 0.062 13.6 7.4 1.2 9.5 1.1 3.1 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF948) GAS PF13851.6 EMD62549.1 - 0.11 11.9 5.7 0.1 11.9 1.9 2.2 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding DUF1664 PF07889.12 EMD62549.1 - 0.13 12.3 8.8 2.1 8.4 1.9 3.0 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) Sec34 PF04136.15 EMD62549.1 - 0.13 12.1 5.5 1.6 8.6 1.6 2.4 1 1 2 3 3 3 0 Sec34-like family DUF16 PF01519.16 EMD62549.1 - 0.15 12.6 7.4 0.34 11.4 1.6 2.3 1 1 1 2 2 2 0 Protein of unknown function DUF16 BRE1 PF08647.11 EMD62549.1 - 0.18 11.9 5.8 0.63 10.1 1.9 2.3 1 1 0 2 2 2 0 BRE1 E3 ubiquitin ligase CALCOCO1 PF07888.11 EMD62549.1 - 0.19 10.5 7.0 0.24 10.2 7.0 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like PspB PF06667.12 EMD62549.1 - 0.21 11.6 1.6 6.6 6.9 0.0 3.2 3 1 1 4 4 3 0 Phage shock protein B Spectrin PF00435.21 EMD62549.1 - 0.23 12.0 3.9 0.4 11.2 1.1 2.5 1 1 1 2 2 2 0 Spectrin repeat DHR10 PF18595.1 EMD62549.1 - 0.24 11.5 3.6 0.35 10.9 0.9 2.3 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain NPV_P10 PF05531.12 EMD62549.1 - 0.24 11.9 11.3 0.9 10.1 2.5 3.5 2 1 2 4 4 3 0 Nucleopolyhedrovirus P10 protein DUF745 PF05335.13 EMD62549.1 - 0.26 11.0 0.7 4.7 6.9 0.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF745) Atg14 PF10186.9 EMD62549.1 - 0.43 9.6 6.3 0.47 9.5 4.9 1.7 1 1 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 zf-C4H2 PF10146.9 EMD62549.1 - 0.69 10.2 3.8 0.84 9.9 2.1 1.8 2 0 0 2 2 2 0 Zinc finger-containing protein ADIP PF11559.8 EMD62549.1 - 0.7 10.0 8.6 0.8 9.8 2.7 2.8 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding Csm1_N PF18504.1 EMD62549.1 - 1 9.8 7.0 0.43 10.9 0.3 3.0 3 1 1 4 4 3 0 Csm1 N-terminal domain Tup_N PF08581.10 EMD62549.1 - 1.1 9.6 4.7 10 6.5 0.2 3.2 1 1 2 4 4 4 0 Tup N-terminal KxDL PF10241.9 EMD62549.1 - 1.8 8.9 7.2 5.1 7.5 0.8 3.1 2 1 1 3 3 3 0 Uncharacterized conserved protein Fib_alpha PF08702.10 EMD62549.1 - 2.3 8.4 6.9 2 8.6 4.5 2.1 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family CorA PF01544.18 EMD62549.1 - 3.7 6.8 11.1 0.42 9.9 3.6 2.4 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein FliD_N PF02465.18 EMD62549.1 - 6.4 7.5 8.4 19 6.0 1.0 2.9 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 N-terminus Abhydrolase_6 PF12697.7 EMD62554.1 - 3.4e-11 44.2 0.4 5.1e-11 43.6 0.4 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EMD62554.1 - 3.4e-11 42.9 0.0 5.3e-11 42.2 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EMD62554.1 - 2.4e-09 37.2 0.1 2.1e-08 34.1 0.1 2.0 1 1 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_3 PF07859.13 EMD62554.1 - 0.00015 21.7 0.0 0.00023 21.1 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold BAAT_C PF08840.11 EMD62554.1 - 0.015 15.2 0.0 0.023 14.6 0.0 1.3 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal Cutinase PF01083.22 EMD62554.1 - 0.022 14.7 0.0 0.033 14.1 0.0 1.2 1 0 0 1 1 1 0 Cutinase Peptidase_S9 PF00326.21 EMD62554.1 - 0.13 11.7 0.0 0.6 9.5 0.0 1.9 1 1 0 1 1 1 0 Prolyl oligopeptidase family Anemone_cytotox PF06369.12 EMD62555.1 - 0.014 15.0 0.0 0.019 14.6 0.0 1.2 1 0 0 1 1 1 0 Sea anemone cytotoxic protein Abhydrolase_1 PF00561.20 EMD62556.1 - 6e-21 75.2 0.0 1.6e-20 73.9 0.0 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EMD62556.1 - 9.7e-16 59.0 0.4 9.1e-15 55.9 0.4 2.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EMD62556.1 - 1.4e-15 57.2 0.0 6e-15 55.2 0.0 1.9 2 0 0 2 2 2 1 Serine aminopeptidase, S33 DUF915 PF06028.11 EMD62556.1 - 3.5e-05 23.3 0.0 0.00018 20.9 0.0 2.1 2 1 0 2 2 2 1 Alpha/beta hydrolase of unknown function (DUF915) Esterase PF00756.20 EMD62556.1 - 0.00023 20.9 0.0 0.00048 19.9 0.0 1.5 1 0 0 1 1 1 1 Putative esterase Chlorophyllase PF07224.11 EMD62556.1 - 0.0072 15.4 0.0 0.011 14.8 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase Thioesterase PF00975.20 EMD62556.1 - 0.014 15.5 0.9 0.19 11.8 0.8 2.5 1 1 0 1 1 1 0 Thioesterase domain Chlorophyllase2 PF12740.7 EMD62556.1 - 0.026 13.5 0.0 0.039 12.9 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase enzyme PGAP1 PF07819.13 EMD62556.1 - 0.073 12.8 0.0 0.36 10.5 0.0 1.9 2 0 0 2 2 2 0 PGAP1-like protein Abhydrolase_3 PF07859.13 EMD62556.1 - 0.14 12.0 0.0 0.48 10.2 0.0 1.9 2 0 0 2 2 2 0 alpha/beta hydrolase fold LIDHydrolase PF10230.9 EMD62556.1 - 0.16 11.5 0.0 0.55 9.7 0.0 1.8 2 0 0 2 2 2 0 Lipid-droplet associated hydrolase Spo7 PF03907.13 EMD62557.1 - 3.2e-85 285.1 0.0 5.1e-85 284.4 0.0 1.3 1 0 0 1 1 1 1 Spo7-like protein HTH_38 PF13936.6 EMD62558.1 - 0.01 15.6 0.0 0.023 14.4 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain Sec7 PF01369.20 EMD62560.1 - 2.8e-69 232.5 1.0 1e-68 230.6 0.2 2.5 2 0 0 2 2 2 1 Sec7 domain Sec7_N PF12783.7 EMD62560.1 - 1.2e-41 142.3 1.4 1.2e-41 142.3 1.4 3.1 2 0 0 2 2 2 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF1981 PF09324.10 EMD62560.1 - 8.6e-38 128.1 11.5 9.8e-33 111.9 0.1 6.9 7 0 0 7 7 7 2 Domain of unknown function (DUF1981) DCB PF16213.5 EMD62560.1 - 8.8e-20 71.1 3.8 2.4e-19 69.7 0.0 3.5 4 0 0 4 4 4 1 Dimerisation and cyclophilin-binding domain of Mon2 Phage_tail_U PF06141.11 EMD62560.1 - 0.042 14.2 0.5 0.13 12.7 0.5 1.8 1 0 0 1 1 1 0 Phage minor tail protein U RIH_assoc PF08454.11 EMD62560.1 - 0.39 10.6 3.1 22 5.0 0.1 3.8 4 0 0 4 4 4 0 RyR and IP3R Homology associated CDC45 PF02724.14 EMD62560.1 - 0.42 8.9 13.9 0.9 7.7 13.9 1.5 1 0 0 1 1 1 0 CDC45-like protein TFIIF_alpha PF05793.12 EMD62560.1 - 4.8 5.7 23.2 9.7 4.7 22.6 1.7 2 0 0 2 2 2 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) 2-oxoacid_dh PF00198.23 EMD62561.1 - 4.7e-71 238.9 0.1 5.9e-71 238.6 0.1 1.1 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 EMD62561.1 - 2.9e-19 68.7 0.7 7.8e-19 67.3 0.4 2.0 1 1 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 EMD62561.1 - 1.4e-12 47.7 0.9 3.8e-12 46.3 0.9 1.8 1 0 0 1 1 1 1 e3 binding domain Fungal_trans_2 PF11951.8 EMD62562.1 - 8.3e-09 34.7 4.6 2.3e-08 33.2 4.6 1.7 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD62562.1 - 1.5e-06 28.2 8.2 3.3e-06 27.1 8.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain HSP70 PF00012.20 EMD62563.1 - 8e-162 539.5 0.4 8e-162 539.5 0.4 2.3 1 1 1 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.13 EMD62563.1 - 3.1e-13 49.3 0.0 1.5e-11 43.7 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein CENP-L PF13092.6 EMD62564.1 - 4.1e-43 147.4 1.5 5.9e-43 146.9 1.5 1.2 1 0 0 1 1 1 1 Kinetochore complex Sim4 subunit Fta1 PLDc_2 PF13091.6 EMD62565.1 - 2.4e-15 56.6 0.7 2e-06 27.8 0.0 3.9 4 0 0 4 4 4 3 PLD-like domain PLDc PF00614.22 EMD62565.1 - 2.9e-13 49.4 2.9 2.2e-07 30.8 0.1 2.6 2 0 0 2 2 2 2 Phospholipase D Active site motif Glyco_hydro_43 PF04616.14 EMD62566.1 - 3.9e-32 111.7 0.7 8.9e-32 110.5 0.7 1.6 1 1 0 1 1 1 1 Glycosyl hydrolases family 43 adh_short PF00106.25 EMD62567.1 - 4.2e-46 156.9 0.0 5.4e-46 156.5 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD62567.1 - 6.7e-32 110.9 0.0 8.6e-32 110.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD62567.1 - 6.4e-08 32.7 0.0 9.8e-08 32.1 0.0 1.2 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 EMD62567.1 - 4.1e-06 26.8 0.0 6.3e-06 26.2 0.0 1.4 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EMD62567.1 - 5.5e-05 22.7 0.0 7.8e-05 22.2 0.0 1.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 EMD62567.1 - 0.0025 17.4 0.2 0.0046 16.5 0.2 1.6 1 1 0 1 1 1 1 NmrA-like family RmlD_sub_bind PF04321.17 EMD62567.1 - 0.0035 16.5 0.0 0.0066 15.6 0.0 1.5 2 0 0 2 2 2 1 RmlD substrate binding domain GDP_Man_Dehyd PF16363.5 EMD62567.1 - 0.031 13.7 0.0 0.049 13.0 0.0 1.4 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase MCM PF00493.23 EMD62568.1 - 1.8e-96 321.6 0.0 4.8e-96 320.2 0.1 1.7 2 0 0 2 2 2 1 MCM P-loop domain MCM_OB PF17207.3 EMD62568.1 - 6.5e-31 106.8 0.0 1.2e-30 105.9 0.0 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EMD62568.1 - 6.7e-23 80.9 0.9 1.5e-22 79.8 0.9 1.6 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 EMD62568.1 - 6.2e-13 49.2 0.0 1.9e-12 47.6 0.0 1.9 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 EMD62568.1 - 1.3e-07 31.2 0.0 1.8e-06 27.5 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 EMD62568.1 - 0.0056 16.5 0.0 0.012 15.4 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EMD62568.1 - 0.014 15.1 0.0 0.036 13.8 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain BUD22 PF09073.10 EMD62568.1 - 0.16 11.3 10.7 0.23 10.7 10.7 1.1 1 0 0 1 1 1 0 BUD22 Rep_fac-A_3 PF08661.11 EMD62569.1 - 0.096 13.0 0.0 0.16 12.4 0.0 1.4 1 0 0 1 1 1 0 Replication factor A protein 3 Plasmodium_Vir PF05795.11 EMD62570.1 - 0.019 14.4 0.3 0.023 14.1 0.3 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Yip1 PF04893.17 EMD62570.1 - 0.056 13.2 0.0 0.095 12.4 0.0 1.4 1 0 0 1 1 1 0 Yip1 domain DUF2207 PF09972.9 EMD62570.1 - 0.12 11.1 0.0 0.14 10.9 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) SpoV PF08183.11 EMD62570.1 - 2 8.4 3.3 3.2 7.8 3.3 1.3 1 0 0 1 1 1 0 Stage V sporulation protein family Na_H_Exchanger PF00999.21 EMD62571.1 - 2e-39 135.5 21.8 2.7e-39 135.1 21.8 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family HupE_UreJ PF04955.12 EMD62571.1 - 0.02 14.3 0.2 0.02 14.3 0.2 3.1 4 1 0 4 4 4 0 HupE / UreJ protein YrhC PF14143.6 EMD62571.1 - 0.026 14.6 4.6 0.026 14.6 0.4 3.2 3 0 0 3 3 3 0 YrhC-like protein DJ-1_PfpI PF01965.24 EMD62573.1 - 7.9e-13 48.5 0.0 2.3e-12 47.0 0.0 1.8 1 1 0 1 1 1 1 DJ-1/PfpI family ThiJ_like PF17124.5 EMD62573.1 - 7.9e-06 25.7 0.0 5e-05 23.1 0.0 1.9 1 1 0 1 1 1 1 ThiJ/PfpI family-like Cutinase PF01083.22 EMD62574.1 - 4.5e-27 95.1 0.3 6.4e-27 94.6 0.3 1.2 1 0 0 1 1 1 1 Cutinase EF-hand_1 PF00036.32 EMD62575.1 - 0.015 14.8 0.0 0.037 13.6 0.0 1.7 1 0 0 1 1 1 0 EF hand EF-hand_7 PF13499.6 EMD62575.1 - 0.047 14.2 0.0 0.072 13.5 0.0 1.3 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_6 PF13405.6 EMD62575.1 - 0.12 12.4 0.0 0.34 11.0 0.0 1.8 1 0 0 1 1 1 0 EF-hand domain NUMOD1 PF07453.13 EMD62576.1 - 0.038 14.3 0.0 0.093 13.0 0.0 1.7 1 0 0 1 1 1 0 NUMOD1 domain Peptidase_C14 PF00656.22 EMD62577.1 - 0.0055 16.7 0.1 0.018 15.0 0.1 1.7 1 1 1 2 2 2 1 Caspase domain Ammonium_transp PF00909.21 EMD62578.1 - 1.7e-99 333.2 18.7 2e-99 333.0 18.7 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family NUDIX_4 PF14815.6 EMD62579.1 - 8.6e-19 67.5 0.0 2.2e-18 66.2 0.0 1.7 1 0 0 1 1 1 1 NUDIX domain HhH-GPD PF00730.25 EMD62579.1 - 1.1e-17 64.4 0.0 5.3e-17 62.2 0.0 2.1 3 0 0 3 3 3 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 EMD62579.1 - 7.3e-05 22.4 1.0 0.00021 21.0 0.1 2.3 2 0 0 2 2 2 1 Helix-hairpin-helix motif HHH_5 PF14520.6 EMD62579.1 - 0.021 15.4 0.0 5.9 7.6 0.0 2.9 3 0 0 3 3 3 0 Helix-hairpin-helix domain EndIII_4Fe-2S PF10576.9 EMD62579.1 - 0.55 10.6 4.9 1.9 8.9 4.9 2.0 1 1 0 1 1 1 0 Iron-sulfur binding domain of endonuclease III RAC_head PF16717.5 EMD62579.1 - 5.1 8.1 5.8 0.93 10.5 0.5 2.5 3 0 0 3 3 3 0 Ribosome-associated complex head domain Glyco_transf_41 PF13844.6 EMD62580.1 - 1e-107 360.5 0.0 1e-56 192.4 0.0 3.1 1 1 1 2 2 2 2 Glycosyl transferase family 41 TPR_2 PF07719.17 EMD62580.1 - 1.9e-15 55.6 14.6 0.015 15.4 0.0 6.0 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_1 PF00515.28 EMD62580.1 - 8.3e-15 53.9 14.1 0.0021 17.8 0.0 6.2 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_8 PF13181.6 EMD62580.1 - 5.8e-13 48.0 9.3 0.0063 16.6 0.1 5.4 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_11 PF13414.6 EMD62580.1 - 2.3e-11 43.2 15.3 0.0023 17.6 0.1 6.4 4 1 2 6 6 6 3 TPR repeat TPR_12 PF13424.6 EMD62580.1 - 5.5e-09 36.2 10.6 0.00033 20.9 0.4 4.4 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.6 EMD62580.1 - 2.3e-08 33.8 8.8 0.4 11.2 0.2 5.6 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_14 PF13428.6 EMD62580.1 - 1.8e-07 31.4 6.7 0.35 11.8 0.0 5.9 3 2 2 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 EMD62580.1 - 3.9e-07 30.5 13.4 0.0007 20.1 0.3 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_10 PF13374.6 EMD62580.1 - 2.7e-05 23.9 15.9 0.24 11.3 0.1 5.9 5 1 1 6 6 6 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EMD62580.1 - 0.00067 19.8 1.1 0.16 12.2 0.5 2.8 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 EMD62580.1 - 0.0011 18.8 7.0 6.9 7.0 0.1 4.7 5 0 0 5 5 5 2 Tetratricopeptide repeat BTAD PF03704.17 EMD62580.1 - 0.0016 18.9 1.8 3.8 7.9 0.0 3.6 3 0 0 3 3 3 1 Bacterial transcriptional activator domain TPR_16 PF13432.6 EMD62580.1 - 0.0064 17.1 11.9 1.4 9.6 0.0 4.9 3 2 3 6 6 6 2 Tetratricopeptide repeat TPR_9 PF13371.6 EMD62580.1 - 0.63 10.2 3.4 4.3 7.5 0.2 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_4 PF07721.14 EMD62580.1 - 2.9 8.8 6.7 84 4.2 0.8 4.0 3 0 0 3 3 3 0 Tetratricopeptide repeat Sec62 PF03839.16 EMD62582.1 - 8.9e-77 257.5 0.8 8.9e-77 257.5 0.8 2.0 2 0 0 2 2 2 1 Translocation protein Sec62 PAT1 PF09770.9 EMD62582.1 - 2.3 6.4 15.3 3.4 5.8 15.3 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DASH_Spc34 PF08657.10 EMD62583.1 - 0.0032 17.3 2.3 0.7 9.7 0.1 2.2 2 0 0 2 2 2 2 DASH complex subunit Spc34 DUF2046 PF09755.9 EMD62583.1 - 0.0052 16.1 0.9 0.33 10.2 0.0 2.2 2 0 0 2 2 2 1 Uncharacterized conserved protein H4 (DUF2046) Pox_A_type_inc PF04508.12 EMD62583.1 - 0.0068 16.2 2.7 0.017 15.0 2.7 1.7 1 0 0 1 1 1 1 Viral A-type inclusion protein repeat Atg14 PF10186.9 EMD62583.1 - 0.047 12.8 2.8 0.59 9.2 0.2 2.2 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 PKcGMP_CC PF16808.5 EMD62583.1 - 0.087 12.7 1.9 0.16 11.9 0.7 1.9 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF1465 PF07323.12 EMD62583.1 - 0.17 11.7 2.7 0.16 11.8 0.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1465) IFP_35_N PF07334.13 EMD62583.1 - 0.32 11.1 4.6 0.16 12.1 0.9 2.2 2 0 0 2 2 2 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus BBP1_C PF15272.6 EMD62583.1 - 0.59 9.9 3.7 0.14 12.0 0.5 1.5 2 0 0 2 2 2 0 Spindle pole body component BBP1, C-terminal Spc24 PF08286.11 EMD62583.1 - 1.1 9.6 4.0 1.5 9.1 0.3 2.1 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 DivIC PF04977.15 EMD62583.1 - 3.4 7.5 8.8 0.94 9.3 1.3 2.3 2 0 0 2 2 2 0 Septum formation initiator PspB PF06667.12 EMD62583.1 - 7.4 6.7 6.2 0.5 10.5 0.7 1.8 2 0 0 2 2 2 0 Phage shock protein B PH PF00169.29 EMD62585.1 - 0.067 13.7 0.0 0.16 12.5 0.0 1.6 1 0 0 1 1 1 0 PH domain DUF1682 PF07946.14 EMD62585.1 - 0.11 11.6 0.1 0.19 10.9 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Thioredoxin PF00085.20 EMD62586.1 - 0.097 12.7 0.1 0.19 11.7 0.1 1.4 1 0 0 1 1 1 0 Thioredoxin UPF0239 PF06783.11 EMD62586.1 - 0.42 10.8 2.8 0.71 10.1 2.8 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0239) Zn_clus PF00172.18 EMD62587.1 - 2.6e-07 30.6 11.6 4.8e-07 29.8 11.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ResIII PF04851.15 EMD62588.1 - 1.3e-24 87.1 0.0 2.8e-24 86.0 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EMD62588.1 - 1.4e-14 54.4 0.0 1.8e-13 50.8 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 EMD62588.1 - 4.8e-12 46.0 0.0 9.4e-12 45.1 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF2075 PF09848.9 EMD62588.1 - 0.0027 17.0 0.0 0.0054 16.0 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) rve PF00665.26 EMD62588.1 - 0.0056 16.9 0.8 7 6.9 0.0 3.4 3 0 0 3 3 3 1 Integrase core domain AAA_22 PF13401.6 EMD62588.1 - 0.053 13.8 0.1 0.67 10.2 0.0 2.7 2 1 0 2 2 2 0 AAA domain SwrA PF17423.2 EMD62588.1 - 0.083 12.9 0.0 0.24 11.4 0.0 1.7 1 0 0 1 1 1 0 Swarming motility protein Mo-co_dimer PF03404.16 EMD62589.1 - 1.5e-58 196.7 0.1 3e-58 195.7 0.1 1.5 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain Oxidored_molyb PF00174.19 EMD62589.1 - 2.8e-53 180.1 0.0 4.9e-53 179.3 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain FAD_binding_6 PF00970.24 EMD62589.1 - 2e-35 121.1 0.0 3.7e-35 120.2 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 EMD62589.1 - 3e-30 105.1 0.2 1.7e-29 102.7 0.1 2.3 3 0 0 3 3 3 1 Oxidoreductase NAD-binding domain Cyt-b5 PF00173.28 EMD62589.1 - 3.1e-20 72.1 0.0 7.3e-20 70.9 0.0 1.7 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain NAD_binding_6 PF08030.12 EMD62589.1 - 0.00049 20.3 0.2 0.013 15.6 0.0 2.3 1 1 0 2 2 2 1 Ferric reductase NAD binding domain Pyr_redox_2 PF07992.14 EMD62590.1 - 1.5e-42 145.9 0.2 2.3e-42 145.2 0.2 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NIR_SIR PF01077.22 EMD62590.1 - 1.4e-20 73.4 0.0 3.1e-20 72.3 0.0 1.6 1 0 0 1 1 1 1 Nitrite and sulphite reductase 4Fe-4S domain Rieske PF00355.26 EMD62590.1 - 2.9e-16 59.2 0.4 1.2e-15 57.2 0.0 2.2 2 0 0 2 2 2 1 Rieske [2Fe-2S] domain Pyr_redox PF00070.27 EMD62590.1 - 9.1e-15 55.0 8.3 1.7e-14 54.1 0.9 3.1 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Fer2_BFD PF04324.15 EMD62590.1 - 2.4e-14 53.4 6.3 1.7e-11 44.3 5.5 2.8 2 0 0 2 2 2 2 BFD-like [2Fe-2S] binding domain Rieske_2 PF13806.6 EMD62590.1 - 5.4e-14 52.0 0.0 1.7e-13 50.4 0.0 1.9 2 0 0 2 2 2 1 Rieske-like [2Fe-2S] domain NIR_SIR_ferr PF03460.17 EMD62590.1 - 1.2e-08 34.6 0.0 2.9e-08 33.5 0.0 1.6 1 0 0 1 1 1 1 Nitrite/Sulfite reductase ferredoxin-like half domain Rubredoxin_C PF18267.1 EMD62590.1 - 3.7e-05 23.6 0.3 0.14 12.1 0.0 3.5 4 0 0 4 4 4 2 Rubredoxin NAD+ reductase C-terminal domain NAD_binding_9 PF13454.6 EMD62590.1 - 0.00043 20.3 0.1 2.3 8.2 0.0 3.3 2 1 1 3 3 3 2 FAD-NAD(P)-binding Amino_oxidase PF01593.24 EMD62590.1 - 0.0026 17.1 0.1 0.7 9.1 0.0 2.3 1 1 1 2 2 2 2 Flavin containing amine oxidoreductase GIDA PF01134.22 EMD62590.1 - 0.024 13.7 0.8 0.81 8.7 0.6 2.8 2 1 1 3 3 3 0 Glucose inhibited division protein A NAD_binding_8 PF13450.6 EMD62590.1 - 0.085 13.1 0.0 2.8 8.2 0.0 2.6 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 EMD62590.1 - 0.18 10.9 0.0 0.81 8.8 0.0 1.9 1 1 1 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) p450 PF00067.22 EMD62591.1 - 8.7e-18 64.3 0.0 9.7e-18 64.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 MFS_1 PF07690.16 EMD62592.1 - 3.8e-42 144.5 45.2 3.8e-42 144.5 45.2 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EMD62592.1 - 5.3e-08 32.2 13.2 5.3e-08 32.2 13.2 2.7 2 1 1 3 3 3 1 Sugar (and other) transporter DUF3067 PF11267.8 EMD62593.1 - 0.062 13.9 0.1 0.34 11.5 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3067) MbeB_N PF04837.12 EMD62593.1 - 0.096 13.0 0.7 0.18 12.2 0.7 1.5 1 0 0 1 1 1 0 MbeB-like, N-term conserved region FXMRP1_C_core PF12235.8 EMD62593.1 - 0.098 13.3 0.0 0.15 12.7 0.0 1.2 1 0 0 1 1 1 0 Fragile X-related 1 protein core C terminal V-SNARE_C PF12352.8 EMD62594.1 - 8.9e-15 54.7 0.6 5.7e-14 52.1 0.2 2.4 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 EMD62594.1 - 0.00072 19.4 0.0 0.005 16.7 0.0 2.2 2 0 0 2 2 2 1 Sec20 PilJ PF13675.6 EMD62594.1 - 0.023 14.7 2.8 0.045 13.8 2.8 1.5 1 0 0 1 1 1 0 Type IV pili methyl-accepting chemotaxis transducer N-term WEMBL PF05701.11 EMD62594.1 - 0.024 13.3 0.9 0.036 12.8 0.9 1.2 1 0 0 1 1 1 0 Weak chloroplast movement under blue light KxDL PF10241.9 EMD62594.1 - 0.11 12.8 5.6 1.4 9.3 1.5 3.3 3 1 0 3 3 3 0 Uncharacterized conserved protein DUF3958 PF13125.6 EMD62594.1 - 0.14 12.4 2.4 11 6.3 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3958) T2SSM PF04612.12 EMD62594.1 - 2.2 8.3 5.8 5.8 7.0 1.6 2.4 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein M DUF4337 PF14235.6 EMD62594.1 - 2.7 8.1 4.4 1.2 9.2 1.8 1.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4337) Peptidase_M28 PF04389.17 EMD62595.1 - 3e-27 95.6 0.1 6.4e-27 94.5 0.1 1.5 1 1 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 EMD62595.1 - 1.9e-05 24.5 0.0 3e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Vps62 PF06101.11 EMD62596.1 - 8.3e-06 24.4 0.0 1.2e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 62 SPX PF03105.19 EMD62597.1 - 0.026 14.5 1.6 0.035 14.0 1.6 1.2 1 0 0 1 1 1 0 SPX domain Med7 PF05983.11 EMD62597.1 - 0.038 14.1 1.6 0.063 13.4 1.6 1.6 1 1 0 1 1 1 0 MED7 protein SpoOE-like PF09388.10 EMD62597.1 - 0.23 11.4 1.1 0.56 10.1 1.1 1.6 1 0 0 1 1 1 0 Spo0E like sporulation regulatory protein FYDLN_acid PF09538.10 EMD62597.1 - 1 10.1 3.7 0.97 10.1 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) DUF726 PF05277.12 EMD62598.1 - 0.19 10.7 0.0 0.3 10.0 0.0 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF726) Cu-oxidase_2 PF07731.14 EMD62599.1 - 1.6e-42 144.5 5.2 1.7e-40 138.0 0.0 3.2 2 1 0 2 2 2 2 Multicopper oxidase Cu-oxidase_3 PF07732.15 EMD62599.1 - 4.6e-40 136.3 3.5 2.1e-39 134.2 2.2 2.6 3 0 0 3 3 3 1 Multicopper oxidase Cu-oxidase PF00394.22 EMD62599.1 - 5.5e-35 120.8 0.4 3.3e-34 118.3 0.1 2.2 2 0 0 2 2 2 1 Multicopper oxidase p450 PF00067.22 EMD62600.1 - 5.1e-41 140.9 0.0 6.8e-41 140.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 FAD_binding_4 PF01565.23 EMD62601.1 - 4e-25 88.2 3.6 4e-25 88.2 3.6 1.7 2 0 0 2 2 2 1 FAD binding domain BBE PF08031.12 EMD62601.1 - 1.3e-05 25.2 0.3 2.5e-05 24.3 0.3 1.4 1 0 0 1 1 1 1 Berberine and berberine like polyprenyl_synt PF00348.17 EMD62602.1 - 1.4e-51 175.0 0.0 2.9e-51 174.0 0.0 1.4 2 0 0 2 2 2 1 Polyprenyl synthetase Terpene_synth_C PF03936.16 EMD62602.1 - 0.00031 20.2 0.1 0.01 15.2 0.0 2.2 2 0 0 2 2 2 2 Terpene synthase family, metal binding domain p450 PF00067.22 EMD62603.1 - 6.7e-63 213.0 0.0 8.3e-63 212.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Glyco_tranf_2_3 PF13641.6 EMD62604.1 - 1.3e-26 93.9 0.0 1.7e-26 93.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 EMD62604.1 - 3.6e-25 88.7 0.0 5.6e-25 88.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_trans_2_3 PF13632.6 EMD62604.1 - 8.2e-09 35.7 0.1 8.2e-09 35.7 0.1 2.6 3 0 0 3 3 3 1 Glycosyl transferase family group 2 Chitin_synth_2 PF03142.15 EMD62604.1 - 2.5e-08 33.0 0.0 1.7e-05 23.7 0.0 3.2 2 1 1 3 3 3 2 Chitin synthase Glyco_tranf_2_2 PF10111.9 EMD62604.1 - 1.4e-06 28.0 0.1 2.1e-06 27.5 0.1 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 EMD62604.1 - 6.2e-06 25.8 0.0 2.6e-05 23.8 0.0 1.9 1 1 0 1 1 1 1 Glycosyl transferase family 21 Glyco_tranf_2_4 PF13704.6 EMD62604.1 - 0.065 13.8 0.0 0.27 11.8 0.0 2.1 2 0 0 2 2 2 0 Glycosyl transferase family 2 LysM PF01476.20 EMD62605.1 - 7.1e-16 58.0 0.4 6.6e-08 32.5 0.1 2.2 2 0 0 2 2 2 2 LysM domain FbpA PF05833.11 EMD62606.1 - 0.18 10.5 0.0 0.23 10.2 0.0 1.1 1 0 0 1 1 1 0 Fibronectin-binding protein A N-terminus (FbpA) p450 PF00067.22 EMD62607.1 - 1.6e-61 208.5 0.0 2e-61 208.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 PTR2 PF00854.21 EMD62608.1 - 7.7e-68 229.1 13.8 7.8e-68 229.1 12.7 1.6 1 1 0 1 1 1 1 POT family NDUF_B12 PF08122.12 EMD62608.1 - 0.23 11.5 5.2 2.5 8.2 0.0 3.7 3 0 0 3 3 3 0 NADH-ubiquinone oxidoreductase B12 subunit family Fungal_trans PF04082.18 EMD62609.1 - 1.1e-13 50.8 0.7 1.9e-13 50.1 0.7 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain MFS_1 PF07690.16 EMD62610.1 - 4.7e-30 104.7 18.2 4.7e-30 104.7 18.2 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Gly-zipper_Omp PF13488.6 EMD62610.1 - 1.2 9.2 5.7 22 5.2 0.2 2.9 2 0 0 2 2 2 0 Glycine zipper Orf78 PF06024.12 EMD62611.1 - 1.5 9.1 0.0 1.5 9.1 0.0 3.6 3 1 1 4 4 4 0 Orf78 (ac78) DUF3995 PF13160.6 EMD62611.1 - 7.6 6.9 14.6 0.28 11.6 6.3 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF3995) AA_permease_2 PF13520.6 EMD62612.1 - 5.4e-49 167.2 46.7 6.9e-49 166.8 46.7 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EMD62612.1 - 5.4e-17 61.5 34.2 7.7e-17 61.0 34.2 1.1 1 0 0 1 1 1 1 Amino acid permease GMC_oxred_N PF00732.19 EMD62613.1 - 3.3e-48 164.6 0.0 4.5e-48 164.1 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EMD62613.1 - 5.1e-31 108.1 0.1 8.2e-31 107.5 0.1 1.3 1 0 0 1 1 1 1 GMC oxidoreductase Thi4 PF01946.17 EMD62613.1 - 9.5e-05 21.7 1.3 0.013 14.8 0.2 2.2 2 0 0 2 2 2 2 Thi4 family Pyr_redox_2 PF07992.14 EMD62613.1 - 0.00016 21.0 2.1 0.00053 19.3 1.4 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EMD62613.1 - 0.00019 21.2 6.9 0.0024 17.5 2.9 2.9 2 1 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EMD62613.1 - 0.00021 20.5 2.6 0.0013 17.9 1.2 2.1 2 0 0 2 2 2 1 FAD binding domain NAD_binding_8 PF13450.6 EMD62613.1 - 0.00035 20.7 2.7 0.0011 19.2 2.2 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 EMD62613.1 - 0.044 12.8 0.2 0.14 11.1 0.1 1.8 2 0 0 2 2 2 0 Lycopene cyclase protein FAD_oxidored PF12831.7 EMD62613.1 - 0.31 10.3 2.6 0.86 8.9 1.9 2.0 2 0 0 2 2 2 0 FAD dependent oxidoreductase 3HCDH_N PF02737.18 EMD62613.1 - 0.72 9.7 2.4 1.5 8.7 2.4 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ADC PF06314.11 EMD62614.1 - 0.032 13.8 0.0 0.058 12.9 0.0 1.4 1 0 0 1 1 1 0 Acetoacetate decarboxylase (ADC) FMN_dh PF01070.18 EMD62615.1 - 2.3e-110 368.9 0.1 2.9e-110 368.6 0.1 1.1 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.28 EMD62615.1 - 3.7e-19 68.6 0.0 8.1e-19 67.5 0.0 1.6 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Glu_synthase PF01645.17 EMD62615.1 - 4.3e-05 22.8 0.1 0.00049 19.3 0.0 2.0 2 0 0 2 2 2 1 Conserved region in glutamate synthase IMPDH PF00478.25 EMD62615.1 - 0.0041 16.2 0.5 0.012 14.7 0.3 1.8 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain NMO PF03060.15 EMD62615.1 - 0.007 15.8 1.1 0.14 11.5 0.1 2.2 1 1 1 2 2 2 1 Nitronate monooxygenase BNR_2 PF13088.6 EMD62616.1 - 4.3e-57 193.5 0.9 5.8e-57 193.1 0.9 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR PF02012.20 EMD62616.1 - 3.4e-08 32.3 9.8 0.058 13.4 0.2 4.2 3 0 0 3 3 3 3 BNR/Asp-box repeat Mo-co_dimer PF03404.16 EMD62616.1 - 2.3e-06 27.7 1.8 0.53 10.3 0.1 3.3 3 0 0 3 3 3 3 Mo-co oxidoreductase dimerisation domain PSII_BNR PF14870.6 EMD62616.1 - 0.0001 21.7 1.6 0.27 10.5 0.1 3.1 3 0 0 3 3 3 3 Photosynthesis system II assembly factor YCF48 Sortilin-Vps10 PF15902.5 EMD62616.1 - 0.0095 14.8 1.3 0.5 9.1 0.4 2.7 2 1 0 2 2 2 1 Sortilin, neurotensin receptor 3, CHB_HEX_C PF03174.13 EMD62616.1 - 0.022 14.7 0.2 1.7 8.7 0.0 3.1 3 0 0 3 3 3 0 Chitobiase/beta-hexosaminidase C-terminal domain Sugar_tr PF00083.24 EMD62617.1 - 4.9e-91 305.8 19.2 5.6e-91 305.7 19.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD62617.1 - 5.3e-14 51.9 28.8 5.3e-14 51.9 28.8 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_5 PF05631.14 EMD62617.1 - 0.0001 21.3 0.1 0.00022 20.3 0.1 1.5 1 0 0 1 1 1 1 Sugar-tranasporters, 12 TM UNC-93 PF05978.16 EMD62617.1 - 0.0012 18.6 0.9 0.0012 18.6 0.9 2.4 3 0 0 3 3 3 1 Ion channel regulatory protein UNC-93 Aldo_ket_red PF00248.21 EMD62618.1 - 1.6e-43 149.0 0.0 6.6e-42 143.7 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family Zn_clus PF00172.18 EMD62619.1 - 9.1e-07 28.9 8.5 1.6e-06 28.1 8.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EMD62619.1 - 8e-05 21.8 0.7 0.00015 20.9 0.7 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Epimerase PF01370.21 EMD62620.1 - 2.3e-09 37.1 0.0 9e-09 35.1 0.0 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EMD62620.1 - 0.0014 18.1 0.0 0.0028 17.1 0.0 1.5 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 EMD62620.1 - 0.037 13.0 0.0 0.075 12.0 0.0 1.4 2 0 0 2 2 2 0 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 EMD62620.1 - 0.046 12.8 0.0 0.089 11.9 0.0 1.4 1 0 0 1 1 1 0 RmlD substrate binding domain ORC6 PF05460.13 EMD62621.1 - 0.15 11.3 7.0 0.17 11.1 7.0 1.1 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Aa_trans PF01490.18 EMD62622.1 - 1.2e-77 261.4 26.2 1.6e-77 260.9 26.2 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein EP400_N PF15790.5 EMD62623.1 - 0.039 12.8 2.1 0.047 12.5 2.1 1.1 1 0 0 1 1 1 0 E1A-binding protein p400, N-terminal CiPC PF15800.5 EMD62623.1 - 0.25 11.0 6.9 0.28 10.9 6.9 1.1 1 0 0 1 1 1 0 Clock interacting protein circadian Endonuc_Holl PF10107.9 EMD62623.1 - 0.41 10.5 2.3 0.6 9.9 2.3 1.2 1 0 0 1 1 1 0 Endonuclease related to archaeal Holliday junction resolvase HET PF06985.11 EMD62625.1 - 4.1e-24 85.6 0.0 8.9e-24 84.5 0.0 1.6 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Pkinase PF00069.25 EMD62627.1 - 5.3e-73 245.6 0.0 1.1e-72 244.5 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD62627.1 - 2.9e-51 174.3 0.0 5.5e-51 173.3 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EMD62627.1 - 0.00077 18.3 0.6 0.0016 17.3 0.0 1.8 2 0 0 2 2 2 1 Fungal protein kinase V-ATPase_H_N PF03224.14 EMD62627.1 - 0.0085 15.4 1.2 13 4.9 0.0 3.1 3 0 0 3 3 3 2 V-ATPase subunit H Med15_fungi PF05397.12 EMD62627.1 - 0.011 15.9 0.1 0.027 14.7 0.1 1.6 1 0 0 1 1 1 0 Mediator complex subunit 15 Kinase-like PF14531.6 EMD62627.1 - 0.062 12.6 0.0 0.4 10.0 0.0 2.1 2 0 0 2 2 2 0 Kinase-like adh_short_C2 PF13561.6 EMD62628.1 - 2.9e-36 125.2 0.3 4.4e-36 124.6 0.3 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EMD62628.1 - 2.5e-35 121.7 0.2 3.5e-35 121.2 0.2 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EMD62628.1 - 1e-11 45.1 1.3 1.3e-10 41.4 1.3 2.1 1 1 0 1 1 1 1 KR domain ADH_zinc_N PF00107.26 EMD62628.1 - 0.003 17.6 0.1 0.0052 16.8 0.1 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Epimerase PF01370.21 EMD62628.1 - 0.0041 16.6 0.0 0.0066 15.9 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Pyr_redox PF00070.27 EMD62628.1 - 0.013 16.0 0.3 0.039 14.5 0.3 1.8 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 EMD62628.1 - 0.028 13.7 0.1 0.052 12.8 0.1 1.5 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain DKNYY PF13644.6 EMD62628.1 - 0.032 15.0 0.0 0.053 14.3 0.0 1.4 1 0 0 1 1 1 0 DKNYY family GDP_Man_Dehyd PF16363.5 EMD62628.1 - 0.047 13.1 0.0 0.095 12.1 0.0 1.5 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase ApbA PF02558.16 EMD62628.1 - 0.062 12.9 0.3 0.25 11.0 0.0 2.1 3 0 0 3 3 3 0 Ketopantoate reductase PanE/ApbA FAD_binding_3 PF01494.19 EMD62628.1 - 0.073 12.3 0.1 0.15 11.3 0.1 1.4 1 0 0 1 1 1 0 FAD binding domain BCS1_N PF08740.11 EMD62629.1 - 4e-22 79.1 0.0 1.1e-21 77.7 0.0 1.7 2 0 0 2 2 2 1 BCS1 N terminal AAA PF00004.29 EMD62629.1 - 3e-16 60.0 0.0 5.9e-14 52.6 0.0 2.4 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 EMD62629.1 - 0.0025 18.2 0.0 0.077 13.4 0.0 2.4 2 0 0 2 2 2 1 RNA helicase AAA_33 PF13671.6 EMD62629.1 - 0.0087 16.2 0.0 0.015 15.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 EMD62629.1 - 0.026 14.5 0.0 0.086 12.8 0.0 2.0 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EMD62629.1 - 0.028 14.7 0.0 0.067 13.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EMD62629.1 - 0.041 14.4 0.0 0.44 11.1 0.0 2.7 3 1 0 3 3 3 0 AAA domain AAA_16 PF13191.6 EMD62629.1 - 0.066 13.6 0.1 0.16 12.4 0.1 1.7 1 1 0 1 1 1 0 AAA ATPase domain PPV_E1_C PF00519.17 EMD62629.1 - 0.11 11.3 0.0 0.18 10.6 0.0 1.2 1 0 0 1 1 1 0 Papillomavirus helicase But2 PF09792.9 EMD62630.1 - 2.2e-49 167.5 1.8 2.2e-49 167.5 1.8 1.6 2 0 0 2 2 2 1 Ubiquitin 3 binding protein But2 C-terminal domain NmrA PF05368.13 EMD62631.1 - 1e-15 57.9 0.0 1.5e-15 57.4 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EMD62631.1 - 2.1e-11 44.0 0.0 3.4e-11 43.4 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EMD62631.1 - 0.04 13.4 0.0 0.067 12.6 0.0 1.4 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family COX14 PF14880.6 EMD62632.1 - 0.02 14.7 0.0 0.038 13.8 0.0 1.4 1 0 0 1 1 1 0 Cytochrome oxidase c assembly Cellulase PF00150.18 EMD62633.1 - 2e-49 168.5 5.9 2.6e-49 168.1 5.9 1.1 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) DUF2057 PF09829.9 EMD62633.1 - 0.39 10.9 4.7 1.5 9.0 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2057) PATR PF12951.7 EMD62633.1 - 0.46 10.6 2.2 1.2 9.3 2.2 1.7 1 0 0 1 1 1 0 Passenger-associated-transport-repeat zf-RING_5 PF14634.6 EMD62634.1 - 0.0023 17.9 3.5 0.0045 16.9 3.5 1.5 1 0 0 1 1 1 1 zinc-RING finger domain Wbp11 PF09429.10 EMD62634.1 - 0.3 11.5 7.2 0.72 10.3 7.2 1.6 1 0 0 1 1 1 0 WW domain binding protein 11 DUF1664 PF07889.12 EMD62634.1 - 0.51 10.4 2.0 1.1 9.3 2.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) DUF4355 PF14265.6 EMD62634.1 - 0.51 10.6 8.3 1.2 9.4 8.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4355) DUF4404 PF14357.6 EMD62634.1 - 0.74 10.5 6.4 11 6.7 6.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) DUF16 PF01519.16 EMD62634.1 - 1.2 9.6 9.6 4.3 7.9 9.6 1.8 1 1 0 1 1 1 0 Protein of unknown function DUF16 BLOC1_2 PF10046.9 EMD62634.1 - 2.8 8.3 8.9 2.1 8.7 4.0 2.3 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 P33MONOX PF15302.6 EMD62635.1 - 0.075 12.7 0.0 0.098 12.4 0.0 1.1 1 0 0 1 1 1 0 P33 mono-oxygenase p450 PF00067.22 EMD62636.1 - 3.5e-62 210.6 0.0 5e-62 210.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 RRM_1 PF00076.22 EMD62638.1 - 3.9e-11 42.6 0.3 4.5e-05 23.2 0.2 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EMD62638.1 - 0.004 16.8 0.1 0.0076 15.8 0.1 1.5 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ntox33 PF15533.6 EMD62638.1 - 0.085 13.3 0.1 0.22 12.0 0.1 1.6 1 0 0 1 1 1 0 Bacterial toxin 33 Peptidase_C48 PF02902.19 EMD62638.1 - 0.12 12.2 0.4 1.3 8.8 0.0 2.0 2 0 0 2 2 2 0 Ulp1 protease family, C-terminal catalytic domain 4HBT PF03061.22 EMD62640.1 - 0.076 13.4 0.2 13 6.2 0.0 2.3 2 0 0 2 2 2 0 Thioesterase superfamily MHYT PF03707.16 EMD62642.1 - 1.3e-12 47.7 13.6 1.5e-05 25.1 0.1 4.4 4 0 0 4 4 4 3 Bacterial signalling protein N terminal repeat WD40 PF00400.32 EMD62643.1 - 1.1e-33 114.6 11.5 8.4e-09 35.9 0.3 7.5 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD62643.1 - 4.7e-13 49.2 2.3 0.0043 17.3 0.1 4.9 3 2 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain IKI3 PF04762.12 EMD62643.1 - 0.03 12.3 1.0 0.13 10.3 0.1 2.2 3 0 0 3 3 3 0 IKI3 family Coatomer_WDAD PF04053.14 EMD62643.1 - 0.095 11.7 2.7 0.77 8.7 0.2 2.2 2 0 0 2 2 2 0 Coatomer WD associated region CTP_transf_like PF01467.26 EMD62644.1 - 2.5e-26 92.6 0.0 5.4e-26 91.5 0.0 1.6 1 0 0 1 1 1 1 Cytidylyltransferase-like Tcp11 PF05794.13 EMD62645.1 - 3.4e-99 332.9 0.0 5.2e-99 332.3 0.0 1.2 1 0 0 1 1 1 1 T-complex protein 11 Hemerythrin PF01814.23 EMD62645.1 - 0.26 11.9 5.6 12 6.5 0.2 3.3 3 1 0 3 3 3 0 Hemerythrin HHE cation binding domain BCS1_N PF08740.11 EMD62646.1 - 3.9e-38 131.3 0.0 3.9e-38 131.3 0.0 1.9 2 0 0 2 2 2 1 BCS1 N terminal AAA PF00004.29 EMD62646.1 - 2.3e-16 60.4 0.0 6.2e-07 29.9 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EMD62646.1 - 0.053 13.9 1.7 0.12 12.7 0.4 2.4 2 1 0 2 2 2 0 AAA ATPase domain RuvB_N PF05496.12 EMD62646.1 - 0.058 13.1 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_11 PF13086.6 EMD62646.1 - 0.13 12.0 5.7 0.51 10.1 0.0 2.6 2 0 0 2 2 2 0 AAA domain DNA_pol_phi PF04931.13 EMD62646.1 - 0.75 7.8 14.9 0.13 10.4 6.1 2.1 2 0 0 2 2 2 0 DNA polymerase phi DUF3244 PF11589.8 EMD62646.1 - 2.7 8.1 5.1 5.4 7.2 3.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3244) ALAD PF00490.21 EMD62647.1 - 5.1e-119 397.1 0.0 6e-119 396.9 0.0 1.0 1 0 0 1 1 1 1 Delta-aminolevulinic acid dehydratase Pectinesterase PF01095.19 EMD62650.1 - 8.6e-45 152.7 1.7 1.2e-44 152.3 1.7 1.1 1 0 0 1 1 1 1 Pectinesterase DUF1996 PF09362.10 EMD62653.1 - 5.8e-45 154.1 0.3 7.4e-45 153.8 0.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1996) DLH PF01738.18 EMD62654.1 - 1.2e-22 80.5 0.0 1.5e-22 80.2 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family AMP-binding PF00501.28 EMD62655.1 - 4.3e-53 180.4 0.0 2.7e-52 177.8 0.0 1.9 1 1 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EMD62655.1 - 1.4e-12 48.4 0.1 4.3e-12 46.9 0.0 1.9 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain ARTD15_N PF18084.1 EMD62655.1 - 0.11 12.8 0.0 5.9 7.2 0.0 2.3 2 0 0 2 2 2 0 ARTD15 N-terminal domain Transferase PF02458.15 EMD62656.1 - 7.5e-20 71.0 0.0 2.9e-13 49.3 0.0 3.0 2 1 0 2 2 2 2 Transferase family ACOX PF01756.19 EMD62657.1 - 1.1e-42 145.6 0.6 2.9e-42 144.3 0.4 1.7 2 0 0 2 2 2 1 Acyl-CoA oxidase Acyl-CoA_ox_N PF14749.6 EMD62657.1 - 3e-26 92.4 0.1 8.1e-26 91.0 0.1 1.7 2 0 0 2 2 2 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_M PF02770.19 EMD62657.1 - 2e-07 31.1 0.0 1.7e-06 28.2 0.0 2.3 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.24 EMD62657.1 - 0.0016 18.6 0.5 0.02 15.1 0.5 2.4 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 EMD62657.1 - 0.14 12.8 0.0 0.4 11.4 0.0 1.8 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase, N-terminal domain Zn_clus PF00172.18 EMD62658.1 - 1.6e-08 34.5 14.1 3e-08 33.6 14.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Acetyltransf_1 PF00583.25 EMD62659.1 - 3.4e-12 46.6 0.0 5.2e-12 46.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 EMD62659.1 - 1.5e-08 34.5 0.1 2.7e-08 33.7 0.1 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.7 EMD62659.1 - 3.2e-08 33.6 0.1 4.7e-08 33.0 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EMD62659.1 - 1.1e-05 25.7 0.0 1.9e-05 25.0 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EMD62659.1 - 0.0046 17.0 0.1 0.0084 16.2 0.1 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 EMD62659.1 - 0.033 13.7 0.1 0.04 13.4 0.1 1.3 1 0 0 1 1 1 0 Putative acetyl-transferase CTP_transf_like PF01467.26 EMD62661.1 - 1.2e-22 80.6 0.0 4e-21 75.7 0.0 2.8 3 0 0 3 3 3 1 Cytidylyltransferase-like p450 PF00067.22 EMD62662.1 - 5e-63 213.5 0.0 6e-63 213.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 GRAM PF02893.20 EMD62662.1 - 0.059 13.2 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 GRAM domain MIP PF00230.20 EMD62663.1 - 8e-40 136.9 13.3 1e-39 136.6 13.3 1.1 1 0 0 1 1 1 1 Major intrinsic protein ArAE_1 PF06081.11 EMD62663.1 - 6.9 6.8 10.8 1.6 8.8 6.2 2.1 2 0 0 2 2 2 0 Aromatic acid exporter family member 1 Peroxidase_2 PF01328.17 EMD62664.1 - 1.6e-18 67.9 0.0 2e-18 67.6 0.0 1.1 1 0 0 1 1 1 1 Peroxidase, family 2 HAD_2 PF13419.6 EMD62665.1 - 5.1e-17 62.5 0.0 1.4e-16 61.1 0.0 1.8 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EMD62665.1 - 4.1e-09 37.0 0.0 1.3e-08 35.4 0.0 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EMD62665.1 - 1.4e-05 25.1 0.0 3e-05 24.0 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like WSC PF01822.19 EMD62666.1 - 4.9e-51 170.8 43.9 1.3e-17 63.8 11.3 3.5 3 0 0 3 3 3 3 WSC domain Glyoxal_oxid_N PF07250.11 EMD62666.1 - 8.4e-24 84.1 0.0 6.9e-23 81.1 0.0 2.3 2 1 1 3 3 3 1 Glyoxal oxidase N-terminus DUF1929 PF09118.11 EMD62666.1 - 5.2e-19 68.3 0.0 1.1e-18 67.3 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1929) Chorion_2 PF03964.15 EMD62666.1 - 0.91 10.4 4.6 2 9.3 4.6 1.5 1 0 0 1 1 1 0 Chorion family 2 Methyltransf_23 PF13489.6 EMD62667.1 - 5e-22 78.5 0.0 7.2e-22 78.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMD62667.1 - 1.7e-13 51.1 0.0 3.8e-13 50.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMD62667.1 - 5.4e-11 42.5 0.1 4.2e-10 39.6 0.1 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMD62667.1 - 3e-10 40.6 0.0 5.8e-10 39.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMD62667.1 - 2.8e-09 37.6 0.0 1.4e-08 35.3 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EMD62667.1 - 3.9e-05 23.1 0.0 9.3e-05 21.9 0.0 1.5 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase MTS PF05175.14 EMD62667.1 - 0.0002 21.0 0.0 0.001 18.6 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase small domain FtsJ PF01728.19 EMD62667.1 - 0.0016 18.6 0.0 0.0025 17.9 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_4 PF02390.17 EMD62667.1 - 0.0036 16.8 0.0 0.0062 16.0 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase PrmA PF06325.13 EMD62667.1 - 0.0053 16.2 0.0 0.0071 15.8 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_2 PF00891.18 EMD62667.1 - 0.0086 15.4 0.0 0.24 10.6 0.0 2.1 2 0 0 2 2 2 1 O-methyltransferase domain Methyltransf_16 PF10294.9 EMD62667.1 - 0.025 14.3 0.0 0.043 13.5 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase Ubie_methyltran PF01209.18 EMD62667.1 - 0.064 12.6 0.0 0.11 11.8 0.0 1.5 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family Apt1 PF10351.9 EMD62668.1 - 0.03 13.2 4.1 0.033 13.1 4.1 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Macoilin PF09726.9 EMD62668.1 - 0.21 10.1 3.6 0.23 10.0 3.6 1.1 1 0 0 1 1 1 0 Macoilin family SOG2 PF10428.9 EMD62668.1 - 1.6 7.9 18.4 1.9 7.6 18.4 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Ndc1_Nup PF09531.10 EMD62668.1 - 1.6 7.3 9.3 1.6 7.3 9.3 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SLC12 PF03522.15 EMD62668.1 - 2 7.4 4.2 2.6 7.0 4.2 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Pneumo_att_G PF05539.11 EMD62668.1 - 2.8 7.4 13.7 3.5 7.1 13.7 1.2 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G Lin-8 PF03353.15 EMD62668.1 - 4.3 6.8 6.8 6 6.3 6.8 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist CTP_transf_like PF01467.26 EMD62670.1 - 0.0058 16.8 0.0 0.054 13.7 0.0 2.2 1 1 0 1 1 1 1 Cytidylyltransferase-like Kelch_5 PF13854.6 EMD62671.1 - 6.5e-05 22.8 0.2 0.036 14.0 0.0 3.3 3 0 0 3 3 3 2 Kelch motif Kelch_4 PF13418.6 EMD62671.1 - 0.0017 18.3 0.9 0.8 9.8 0.0 4.0 4 0 0 4 4 4 1 Galactose oxidase, central domain SKG6 PF08693.10 EMD62671.1 - 0.087 12.3 0.5 0.2 11.1 0.5 1.7 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Adeno_E3_CR2 PF02439.15 EMD62671.1 - 0.3 10.9 2.6 0.54 10.1 2.6 1.3 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Meth_synt_2 PF01717.18 EMD62672.1 - 1.1e-151 504.7 0.0 1.1e-146 488.3 0.0 2.2 2 0 0 2 2 2 2 Cobalamin-independent synthase, Catalytic domain Meth_synt_1 PF08267.12 EMD62672.1 - 1.4e-121 405.8 0.1 1.3e-114 382.9 0.0 3.1 3 0 0 3 3 3 2 Cobalamin-independent synthase, N-terminal domain URO-D PF01208.17 EMD62672.1 - 3e-06 26.6 0.0 0.0025 17.0 0.0 2.3 2 0 0 2 2 2 2 Uroporphyrinogen decarboxylase (URO-D) Put_DNA-bind_N PF06971.13 EMD62672.1 - 0.11 12.5 0.1 0.54 10.3 0.1 2.2 2 0 0 2 2 2 0 Putative DNA-binding protein N-terminus adh_short_C2 PF13561.6 EMD62673.1 - 7.5e-46 156.6 0.2 3.5e-40 138.0 0.0 2.1 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EMD62673.1 - 2.7e-45 154.2 0.2 3.5e-45 153.9 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EMD62673.1 - 2.8e-15 56.7 0.0 3.9e-15 56.2 0.0 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EMD62673.1 - 4.7e-05 23.0 0.1 0.00021 20.8 0.1 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF1776 PF08643.10 EMD62673.1 - 0.0035 16.8 0.0 0.0043 16.5 0.0 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) Polysacc_synt_2 PF02719.15 EMD62673.1 - 0.054 12.6 0.1 0.08 12.1 0.1 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein RDD PF06271.12 EMD62674.1 - 1.5 9.0 16.7 4.1 7.6 6.5 2.5 2 1 0 2 2 2 0 RDD family FAD_binding_4 PF01565.23 EMD62675.1 - 1.4e-26 92.9 0.4 2.2e-26 92.2 0.4 1.3 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EMD62675.1 - 0.051 13.7 0.4 0.13 12.3 0.4 1.7 1 0 0 1 1 1 0 Berberine and berberine like HSP20 PF00011.21 EMD62676.1 - 2.7e-14 53.2 0.2 1.5e-09 37.9 0.0 2.6 2 1 0 2 2 2 2 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 EMD62676.1 - 0.0067 16.0 0.0 0.017 14.7 0.0 1.6 1 0 0 1 1 1 1 HSP20-like domain found in ArsA MRPL52 PF18699.1 EMD62676.1 - 0.038 14.2 0.7 0.1 12.8 0.7 1.7 1 0 0 1 1 1 0 Mitoribosomal protein mL52 Fungal_trans_2 PF11951.8 EMD62677.1 - 5.7e-10 38.5 0.1 8.6e-10 38.0 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD62677.1 - 1.2e-07 31.7 9.4 2.3e-07 30.8 9.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RTA1 PF04479.13 EMD62678.1 - 1.7e-69 233.6 10.5 1.7e-69 233.6 10.5 1.7 1 1 1 2 2 2 1 RTA1 like protein Pro_Al_protease PF02983.14 EMD62679.1 - 5.7e-15 55.1 0.3 5.7e-15 55.1 0.3 2.9 1 1 1 2 2 2 1 Alpha-lytic protease prodomain Trypsin PF00089.26 EMD62679.1 - 8.9e-08 32.2 8.9 2.4e-07 30.8 8.9 1.7 1 1 0 1 1 1 1 Trypsin Secretin_N PF03958.17 EMD62679.1 - 0.14 12.6 0.7 3.8 8.0 0.7 2.7 1 1 0 1 1 1 0 Bacterial type II/III secretion system short domain TatD_DNase PF01026.21 EMD62681.1 - 9.5e-42 143.1 0.0 1.1e-41 142.9 0.0 1.0 1 0 0 1 1 1 1 TatD related DNase Ribosomal_S30AE PF02482.19 EMD62681.1 - 0.062 14.1 0.0 0.19 12.5 0.0 1.8 1 1 1 2 2 2 0 Sigma 54 modulation protein / S30EA ribosomal protein Glyco_hydro_36 PF17167.4 EMD62682.1 - 8.1e-62 209.3 0.1 1.7e-61 208.2 0.1 1.5 1 1 0 1 1 1 1 Glycosyl hydrolase 36 superfamily, catalytic domain Glyco_transf_36 PF06165.11 EMD62682.1 - 4e-27 95.2 0.0 6.8e-27 94.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 36 Bac_rhamnosid6H PF17389.2 EMD62682.1 - 1e-05 25.0 0.1 2e-05 24.0 0.1 1.5 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain GDE_C PF06202.14 EMD62682.1 - 9.7e-05 21.5 0.1 0.00017 20.6 0.1 1.3 1 0 0 1 1 1 1 Amylo-alpha-1,6-glucosidase Glyco_hydro_65C PF03633.15 EMD62682.1 - 0.0057 16.6 0.0 0.015 15.2 0.0 1.7 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, C-terminal domain DUF1380 PF07128.12 EMD62682.1 - 0.09 13.0 0.0 0.76 9.9 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1380) WD40 PF00400.32 EMD62683.1 - 0.0019 19.0 5.0 0.0086 16.9 0.2 3.7 3 0 0 3 3 3 1 WD domain, G-beta repeat Ge1_WD40 PF16529.5 EMD62683.1 - 0.1 11.6 0.1 0.77 8.7 0.0 2.2 1 1 1 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein BPL_LplA_LipB PF03099.19 EMD62684.1 - 0.0042 17.0 0.0 0.013 15.4 0.0 1.8 1 1 0 1 1 1 1 Biotin/lipoate A/B protein ligase family zf-C2H2_jaz PF12171.8 EMD62686.1 - 0.13 12.5 5.8 0.42 11.0 1.1 3.0 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 EMD62686.1 - 0.19 12.6 0.4 0.19 12.6 0.4 4.4 3 1 1 4 4 4 0 C2H2-type zinc finger FAD_binding_3 PF01494.19 EMD62687.1 - 8e-29 101.0 0.0 9.8e-29 100.7 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 EMD62687.1 - 3.4e-06 26.9 0.0 0.0015 18.2 0.0 2.3 2 1 0 2 2 2 2 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 EMD62687.1 - 0.00027 20.1 0.3 0.14 11.2 0.0 2.4 2 0 0 2 2 2 2 Lycopene cyclase protein SE PF08491.10 EMD62687.1 - 0.011 14.8 0.0 0.015 14.3 0.0 1.2 1 0 0 1 1 1 0 Squalene epoxidase SSP160 PF06933.11 EMD62687.1 - 5 5.2 5.4 6.4 4.9 5.4 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 GRAB PF10375.9 EMD62688.1 - 1.3e-08 34.4 0.1 2.9e-08 33.3 0.1 1.7 1 0 0 1 1 1 1 GRIP-related Arf-binding domain Atg14 PF10186.9 EMD62688.1 - 0.00083 18.5 15.4 0.00083 18.5 15.4 3.6 2 1 2 4 4 4 1 Vacuolar sorting 38 and autophagy-related subunit 14 ZapB PF06005.12 EMD62688.1 - 0.0026 18.2 10.1 0.0026 18.2 10.1 6.5 3 2 1 5 5 4 1 Cell division protein ZapB Golgin_A5 PF09787.9 EMD62688.1 - 0.0032 17.0 47.2 0.28 10.6 24.9 3.5 1 1 2 3 3 3 1 Golgin subfamily A member 5 bZIP_1 PF00170.21 EMD62688.1 - 0.0034 17.5 3.7 0.0034 17.5 3.7 6.0 7 0 0 7 7 5 1 bZIP transcription factor Filament PF00038.21 EMD62688.1 - 0.0044 16.7 43.4 0.007 16.0 16.4 2.9 1 1 1 2 2 2 1 Intermediate filament protein Baculo_PEP_C PF04513.12 EMD62688.1 - 0.038 14.0 16.4 0.58 10.2 0.1 3.7 2 2 2 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF2721 PF11026.8 EMD62688.1 - 0.048 13.6 2.6 9.3 6.2 0.0 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) DUF3800 PF12686.7 EMD62688.1 - 0.055 14.1 0.0 0.64 10.7 0.0 2.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3800) KASH_CCD PF14662.6 EMD62688.1 - 0.099 12.5 51.1 0.14 12.0 35.9 3.2 1 1 2 3 3 3 0 Coiled-coil region of CCDC155 or KASH JIP_LZII PF16471.5 EMD62688.1 - 0.26 11.5 0.1 0.26 11.5 0.1 6.3 2 1 2 6 6 6 0 JNK-interacting protein leucine zipper II Nup54_57_C PF18570.1 EMD62688.1 - 0.4 10.3 6.8 0.68 9.6 0.2 3.6 3 0 0 3 3 3 0 NUP57/Nup54 C-terminal domain Fib_alpha PF08702.10 EMD62688.1 - 0.6 10.3 27.4 0.42 10.8 6.4 4.4 1 1 3 4 4 4 0 Fibrinogen alpha/beta chain family DUF3138 PF11336.8 EMD62688.1 - 2.1 6.9 11.8 5.5 5.5 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3138) HOOK PF05622.12 EMD62688.1 - 2.6 6.1 51.0 2.8 6.0 33.1 2.8 1 1 1 2 2 2 0 HOOK protein TPR_MLP1_2 PF07926.12 EMD62688.1 - 2.7 8.0 66.1 0.35 10.9 19.6 5.1 2 1 3 5 5 4 0 TPR/MLP1/MLP2-like protein Spc7 PF08317.11 EMD62688.1 - 3.1 6.6 53.4 0.039 12.8 3.6 3.5 1 1 3 4 4 4 0 Spc7 kinetochore protein EzrA PF06160.12 EMD62688.1 - 4.7 5.3 40.8 0.77 7.9 13.0 3.2 1 1 2 3 3 3 0 Septation ring formation regulator, EzrA SHE3 PF17078.5 EMD62688.1 - 6 6.5 34.0 60 3.2 13.0 3.5 1 1 0 2 2 2 0 SWI5-dependent HO expression protein 3 NPV_P10 PF05531.12 EMD62688.1 - 7 7.2 16.9 14 6.2 2.2 4.6 3 2 1 4 4 4 0 Nucleopolyhedrovirus P10 protein Snapin_Pallidin PF14712.6 EMD62688.1 - 7.8 7.0 34.2 3.5 8.1 5.6 5.4 2 2 4 6 6 6 0 Snapin/Pallidin DUF1664 PF07889.12 EMD62688.1 - 9.2 6.3 23.3 13 5.9 5.6 4.4 2 2 2 4 4 4 0 Protein of unknown function (DUF1664) Ribosomal_L32p PF01783.23 EMD62689.1 - 4.3e-12 46.1 2.0 4.3e-12 46.1 2.0 1.7 2 0 0 2 2 2 1 Ribosomal L32p protein family zf-ribbon_3 PF13248.6 EMD62689.1 - 0.0021 17.4 0.5 0.0033 16.8 0.5 1.3 1 0 0 1 1 1 1 zinc-ribbon domain F-box-like_2 PF13013.6 EMD62689.1 - 0.082 12.9 0.4 0.28 11.2 0.2 1.8 2 0 0 2 2 2 0 F-box-like domain Septin PF00735.18 EMD62690.1 - 2.9e-112 374.6 0.5 3.4e-112 374.3 0.5 1.0 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 EMD62690.1 - 2.6e-08 33.9 0.0 5.2e-08 33.0 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EMD62690.1 - 5.9e-06 26.3 0.2 6.7e-05 22.8 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 EMD62690.1 - 1.8e-05 24.3 0.3 0.0055 16.3 0.0 2.3 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain AIG1 PF04548.16 EMD62690.1 - 1.9e-05 24.1 0.0 6.9e-05 22.3 0.0 1.9 2 0 0 2 2 2 1 AIG1 family AAA_16 PF13191.6 EMD62690.1 - 0.0017 18.8 0.0 0.0055 17.1 0.0 1.8 2 0 0 2 2 2 1 AAA ATPase domain Dynamin_N PF00350.23 EMD62690.1 - 0.0017 18.4 0.9 1.1 9.2 0.1 2.7 2 1 1 3 3 3 2 Dynamin family AAA_22 PF13401.6 EMD62690.1 - 0.0076 16.5 0.1 0.016 15.5 0.1 1.6 1 1 0 1 1 1 1 AAA domain AAA_7 PF12775.7 EMD62690.1 - 0.014 15.0 0.0 0.049 13.1 0.0 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region FtsK_SpoIIIE PF01580.18 EMD62690.1 - 0.016 14.6 0.0 0.028 13.8 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family G-alpha PF00503.20 EMD62690.1 - 0.018 14.2 0.6 0.094 11.9 0.1 1.8 1 1 1 2 2 2 0 G-protein alpha subunit ABC_tran PF00005.27 EMD62690.1 - 0.025 15.1 0.6 0.054 14.0 0.6 1.9 1 1 0 1 1 1 0 ABC transporter Ras PF00071.22 EMD62690.1 - 0.038 13.6 0.0 0.093 12.3 0.0 1.7 1 0 0 1 1 1 0 Ras family Roc PF08477.13 EMD62690.1 - 0.061 13.6 0.0 0.14 12.4 0.0 1.6 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_23 PF13476.6 EMD62690.1 - 0.12 12.9 0.3 0.24 11.9 0.2 1.6 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EMD62690.1 - 0.18 11.6 0.0 0.32 10.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Yae1_N PF09811.9 EMD62691.1 - 3.9e-10 39.2 1.7 6.1e-10 38.6 1.7 1.3 1 0 0 1 1 1 1 Essential protein Yae1, N terminal tRNA-synt_1g PF09334.11 EMD62692.1 - 3.5e-153 510.0 0.3 4.6e-153 509.6 0.3 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 EMD62692.1 - 5.4e-09 34.8 0.3 3e-06 25.8 0.0 3.1 2 1 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.19 EMD62692.1 - 0.0078 15.6 0.0 0.031 13.6 0.0 1.9 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain BRF1 PF07741.13 EMD62692.1 - 2.4 8.6 9.3 7 7.1 9.3 1.8 1 0 0 1 1 1 0 Brf1-like TBP-binding domain MFS_1 PF07690.16 EMD62693.1 - 1.3e-16 60.5 43.6 1.9e-14 53.4 43.2 2.3 1 1 0 1 1 1 1 Major Facilitator Superfamily Mpp10 PF04006.12 EMD62695.1 - 5.9e-119 398.3 50.7 2.7e-118 396.1 50.7 1.8 1 1 0 1 1 1 1 Mpp10 protein Mito_carr PF00153.27 EMD62696.1 - 1.2e-64 214.3 0.3 1.6e-23 82.5 0.0 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 EMD62696.1 - 0.11 11.7 0.2 1.3 8.1 0.0 2.6 2 1 0 2 2 2 0 Gammaproteobacterial serine protease UCR_14kD PF02271.16 EMD62697.1 - 6.8e-47 157.6 0.3 8.2e-47 157.3 0.3 1.1 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase complex 14kD subunit Ribosomal_S21 PF01165.20 EMD62697.1 - 0.023 14.4 0.1 4 7.2 0.0 2.2 2 0 0 2 2 2 0 Ribosomal protein S21 Beta-lactamase PF00144.24 EMD62698.1 - 1.6e-38 132.8 0.0 2.5e-38 132.1 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase He_PIG PF05345.12 EMD62698.1 - 0.094 12.9 0.3 0.28 11.4 0.3 1.8 1 0 0 1 1 1 0 Putative Ig domain Beta-lactamase2 PF13354.6 EMD62698.1 - 0.12 11.9 0.0 0.22 11.1 0.0 1.4 1 0 0 1 1 1 0 Beta-lactamase enzyme family Mlo PF03094.15 EMD62699.1 - 0.069 11.5 0.0 0.077 11.4 0.0 1.1 1 0 0 1 1 1 0 Mlo family HhH-GPD PF00730.25 EMD62700.1 - 7.8e-11 42.4 0.0 1.6e-10 41.4 0.0 1.5 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein NinG PF05766.12 EMD62701.1 - 0.047 13.6 0.0 0.072 13.0 0.0 1.3 1 0 0 1 1 1 0 Bacteriophage Lambda NinG protein Vta1_C PF18097.1 EMD62701.1 - 0.054 13.2 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 Vta1 C-terminal domain Ecm33 PF12454.8 EMD62703.1 - 1.8e-10 40.8 5.1 6.5e-10 39.0 5.1 2.0 1 0 0 1 1 1 1 GPI-anchored cell wall organization protein Recep_L_domain PF01030.24 EMD62703.1 - 2.3e-08 34.1 1.3 0.017 15.3 0.1 3.9 2 2 1 3 3 3 2 Receptor L domain LRR_9 PF14580.6 EMD62703.1 - 0.071 12.6 1.1 0.41 10.1 0.2 2.4 2 1 1 3 3 3 0 Leucine-rich repeat Anp1 PF03452.14 EMD62704.1 - 5.1e-107 357.2 0.0 6.6e-107 356.8 0.0 1.1 1 0 0 1 1 1 1 Anp1 G-patch PF01585.23 EMD62705.1 - 2.2e-11 43.5 1.3 5.6e-11 42.2 1.3 1.6 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 EMD62705.1 - 0.00048 20.2 0.3 0.00048 20.2 0.3 2.3 2 0 0 2 2 2 1 G-patch domain RRM_1 PF00076.22 EMD62705.1 - 0.00053 19.8 0.1 0.001 18.8 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Dec-1 PF04624.14 EMD62705.1 - 0.54 10.1 3.0 1.9 8.4 3.0 1.9 1 0 0 1 1 1 0 Dec-1 repeat Rrn6 PF10214.9 EMD62705.1 - 3.6 6.0 12.9 4.9 5.5 12.9 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor AMP-binding PF00501.28 EMD62706.1 - 2.8e-87 293.0 0.0 3.3e-87 292.8 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EMD62706.1 - 5e-15 56.2 0.2 3.2e-14 53.7 0.0 2.3 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain GH3 PF03321.13 EMD62706.1 - 0.00016 20.7 0.0 0.001 18.0 0.0 1.9 2 0 0 2 2 2 1 GH3 auxin-responsive promoter RTX_C PF08339.10 EMD62706.1 - 0.0031 17.6 0.0 0.0064 16.6 0.0 1.5 1 0 0 1 1 1 1 RTX C-terminal domain DUF3841 PF12952.7 EMD62706.1 - 0.11 12.2 0.0 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3841) RdRP_1 PF00680.20 EMD62707.1 - 0.23 9.9 1.0 5.2 5.5 0.1 2.2 2 0 0 2 2 2 0 RNA dependent RNA polymerase Zn_clus PF00172.18 EMD62708.1 - 1.4e-08 34.7 9.0 1.4e-08 34.7 9.0 1.7 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EMD62708.1 - 3.5e-08 32.7 0.3 5.1e-08 32.1 0.3 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain ABM PF03992.16 EMD62709.1 - 0.00019 21.5 0.0 0.35 11.0 0.1 2.2 2 0 0 2 2 2 2 Antibiotic biosynthesis monooxygenase DUF4937 PF16291.5 EMD62709.1 - 0.0018 18.5 0.2 0.024 14.9 0.1 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4937 Glyco_hydro_92 PF07971.12 EMD62710.1 - 5.7e-132 440.9 0.0 3.8e-97 326.1 0.0 2.0 2 0 0 2 2 2 2 Glycosyl hydrolase family 92 Glyco_hydro_92N PF17678.1 EMD62710.1 - 6.8e-53 180.0 0.0 1.2e-52 179.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 N-terminal domain Y_phosphatase2 PF03162.13 EMD62711.1 - 1.3e-42 145.1 0.0 2.7e-42 144.2 0.0 1.4 2 0 0 2 2 2 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.6 EMD62711.1 - 1.2e-11 45.0 0.0 4.7e-11 43.1 0.0 2.0 1 1 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 EMD62711.1 - 0.00056 19.7 0.0 0.00095 19.0 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EMD62711.1 - 0.0018 17.9 0.1 0.0026 17.4 0.1 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DUF3984 PF13136.6 EMD62712.1 - 4e-51 174.4 26.8 2.2e-47 162.1 22.2 2.7 2 1 0 2 2 2 1 Protein of unknown function (DUF3984) Glyco_transf_22 PF03901.17 EMD62713.1 - 9.1e-85 285.4 14.6 1.1e-84 285.1 14.6 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family Pkinase PF00069.25 EMD62714.1 - 6e-49 166.8 0.1 1e-32 113.6 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EMD62714.1 - 5.3e-24 84.9 0.3 4.1e-23 82.0 0.3 2.3 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMD62714.1 - 0.017 14.5 0.0 0.03 13.6 0.0 1.3 1 0 0 1 1 1 0 Kinase-like APH PF01636.23 EMD62714.1 - 0.032 14.2 0.1 0.075 12.9 0.1 1.7 1 1 0 1 1 1 0 Phosphotransferase enzyme family JmjC PF02373.22 EMD62716.1 - 7.7e-10 39.2 0.4 6.8e-09 36.2 0.4 2.4 1 1 0 1 1 1 1 JmjC domain, hydroxylase zf-4CXXC_R1 PF10497.9 EMD62716.1 - 2.1e-07 31.1 6.6 2.1e-07 31.1 6.6 2.5 2 0 0 2 2 2 1 Zinc-finger domain of monoamine-oxidase A repressor R1 Cupin_2 PF07883.11 EMD62716.1 - 0.0025 17.5 0.0 0.0078 15.9 0.0 1.8 1 0 0 1 1 1 1 Cupin domain UbiA PF01040.18 EMD62717.1 - 1.3e-42 145.8 19.7 1.8e-42 145.4 19.7 1.2 1 0 0 1 1 1 1 UbiA prenyltransferase family Herpes_pp38 PF04846.13 EMD62717.1 - 0.039 13.9 0.1 0.11 12.5 0.1 1.7 1 0 0 1 1 1 0 Herpesvirus pp38 phosphoprotein Metallophos_2 PF12850.7 EMD62718.1 - 1.8e-10 41.3 0.0 2.4e-10 40.9 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain TTC5_OB PF16669.5 EMD62718.1 - 0.17 11.5 0.0 0.28 10.9 0.0 1.3 1 0 0 1 1 1 0 Tetratricopeptide repeat protein 5 OB fold domain Inositol_P PF00459.25 EMD62719.1 - 2.3e-40 138.9 1.3 6e-38 130.9 1.3 2.1 1 1 0 1 1 1 1 Inositol monophosphatase family Ecl1 PF12855.7 EMD62721.1 - 1.3e-16 62.3 26.5 1.6e-16 61.9 26.5 1.1 1 0 0 1 1 1 1 ECL1/2/3 zinc binding proteins PLATZ PF04640.14 EMD62721.1 - 0.42 11.3 4.3 0.91 10.2 4.3 1.6 1 0 0 1 1 1 0 PLATZ transcription factor QWRF PF04484.12 EMD62721.1 - 6.6 6.4 11.6 8.3 6.1 11.6 1.1 1 0 0 1 1 1 0 QWRF family Aminotran_5 PF00266.19 EMD62723.1 - 1.1e-30 106.9 0.0 1.4e-30 106.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 EMD62723.1 - 0.00021 20.6 0.0 0.00033 20.0 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EMD62723.1 - 0.00075 18.1 0.0 0.001 17.7 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme SCAPER_N PF16501.5 EMD62726.1 - 0.0018 18.3 0.0 0.0038 17.2 0.0 1.5 1 0 0 1 1 1 1 S phase cyclin A-associated protein in the endoplasmic reticulum Mating_C PF12737.7 EMD62726.1 - 0.013 14.8 1.1 0.018 14.3 1.1 1.1 1 0 0 1 1 1 0 C-terminal domain of homeodomain 1 AhpC-TSA PF00578.21 EMD62728.1 - 7.7e-23 80.7 0.0 1.3e-22 80.0 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EMD62728.1 - 8.5e-15 54.7 0.0 1.7e-14 53.7 0.0 1.5 1 0 0 1 1 1 1 Redoxin AhpC-TSA_2 PF13911.6 EMD62728.1 - 0.058 13.5 0.0 0.57 10.3 0.0 2.0 1 1 1 2 2 2 0 AhpC/TSA antioxidant enzyme Aa_trans PF01490.18 EMD62729.1 - 1.4e-38 132.7 34.7 1.7e-38 132.4 34.7 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 EMD62729.1 - 0.0011 18.0 20.3 0.002 17.2 20.3 1.3 1 0 0 1 1 1 1 Tryptophan/tyrosine permease family VPDSG-CTERM PF18205.1 EMD62729.1 - 0.15 11.9 0.7 0.93 9.4 0.7 2.5 1 0 0 1 1 1 0 VPDSG-CTERM motif zf-RING_2 PF13639.6 EMD62730.1 - 1.3e-09 38.2 5.0 1.3e-09 38.2 5.0 2.1 2 0 0 2 2 2 1 Ring finger domain zf-ANAPC11 PF12861.7 EMD62730.1 - 3.1e-06 27.1 1.8 3.1e-06 27.1 1.8 2.0 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_1 PF14446.6 EMD62730.1 - 3.9e-05 23.5 2.8 3.9e-05 23.5 2.8 2.7 3 0 0 3 3 3 1 Prokaryotic RING finger family 1 zf-rbx1 PF12678.7 EMD62730.1 - 7.8e-05 22.9 3.7 7.8e-05 22.9 3.7 1.8 2 0 0 2 2 2 1 RING-H2 zinc finger domain FANCL_C PF11793.8 EMD62730.1 - 0.0003 20.9 11.0 0.00078 19.6 8.2 2.7 2 1 0 2 2 2 1 FANCL C-terminal domain zf-RING_5 PF14634.6 EMD62730.1 - 0.00072 19.5 5.4 0.00072 19.5 5.4 2.1 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EMD62730.1 - 0.00088 19.1 4.5 0.00088 19.1 4.5 1.7 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.6 EMD62730.1 - 0.0015 18.3 8.2 0.0015 18.3 8.2 1.6 2 0 0 2 2 1 1 RING/Ubox like zinc-binding domain zf-RING_UBOX PF13445.6 EMD62730.1 - 0.0017 18.3 1.9 0.0038 17.2 1.9 1.6 1 0 0 1 1 1 1 RING-type zinc-finger PHD PF00628.29 EMD62730.1 - 0.0024 17.7 6.9 0.0047 16.8 6.9 1.5 1 0 0 1 1 1 1 PHD-finger RINGv PF12906.7 EMD62730.1 - 0.0034 17.5 5.8 0.0034 17.5 5.8 1.7 2 0 0 2 2 1 1 RING-variant domain zf-C3HC4 PF00097.25 EMD62730.1 - 0.0042 16.9 3.8 0.0042 16.9 3.8 2.0 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EMD62730.1 - 0.008 16.0 5.6 0.008 16.0 5.6 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) SWIM PF04434.17 EMD62730.1 - 0.015 14.9 0.1 0.033 13.8 0.1 1.6 1 0 0 1 1 1 0 SWIM zinc finger zf-RING-like PF08746.11 EMD62730.1 - 0.034 14.5 4.5 0.034 14.5 4.5 2.2 3 0 0 3 3 2 0 RING-like domain MTD PF01993.18 EMD62730.1 - 0.17 11.2 0.0 0.27 10.6 0.0 1.3 1 0 0 1 1 1 0 methylene-5,6,7,8-tetrahydromethanopterin dehydrogenase Baculo_IE-1 PF05290.11 EMD62730.1 - 0.25 11.3 3.9 0.43 10.5 3.9 1.4 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) Prok-RING_4 PF14447.6 EMD62730.1 - 0.48 10.3 10.4 0.27 11.1 1.0 2.9 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 zf-C2H2_9 PF16293.5 EMD62730.1 - 0.86 9.5 3.5 22 5.0 0.1 2.7 3 0 0 3 3 2 0 C2H2 type zinc-finger (1 copy) zf-Di19 PF05605.12 EMD62730.1 - 1.4 9.3 0.0 1.4 9.3 0.0 2.7 3 0 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding Gly_transf_sug PF04488.15 EMD62734.1 - 9.9e-09 35.7 0.1 2.3e-08 34.5 0.0 1.7 2 0 0 2 2 2 1 Glycosyltransferase sugar-binding region containing DXD motif Caps_synth PF05704.12 EMD62734.1 - 3.2e-06 26.8 0.0 4.6e-06 26.2 0.0 1.2 1 0 0 1 1 1 1 Capsular polysaccharide synthesis protein DUF4275 PF14101.6 EMD62736.1 - 0.08 13.1 0.0 0.098 12.8 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4275) BNR_2 PF13088.6 EMD62738.1 - 0.00097 18.5 0.2 0.0045 16.3 0.2 1.9 1 1 0 1 1 1 1 BNR repeat-like domain Sortilin-Vps10 PF15902.5 EMD62738.1 - 0.04 12.7 0.4 3.8 6.2 0.1 2.8 2 1 1 3 3 3 0 Sortilin, neurotensin receptor 3, BNR_6 PF15899.5 EMD62738.1 - 0.04 14.0 4.0 7 7.0 0.0 3.8 3 0 0 3 3 3 0 BNR-Asp box repeat BNR PF02012.20 EMD62738.1 - 1.8 8.9 5.4 0.61 10.3 0.1 3.3 3 0 0 3 3 3 0 BNR/Asp-box repeat WSC PF01822.19 EMD62739.1 - 2.6e-13 50.0 6.1 2.6e-13 50.0 6.1 2.4 2 0 0 2 2 2 1 WSC domain DUF349 PF03993.12 EMD62739.1 - 0.1 12.9 0.2 0.16 12.2 0.2 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF349) Asp PF00026.23 EMD62740.1 - 1.7e-33 116.4 0.0 2.2e-33 116.0 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease Asp_protease_2 PF13650.6 EMD62740.1 - 4.8e-06 27.1 0.0 0.015 15.9 0.0 3.5 2 1 0 2 2 2 1 Aspartyl protease gag-asp_proteas PF13975.6 EMD62740.1 - 0.00083 19.9 0.0 0.25 12.0 0.0 3.4 3 1 0 3 3 3 1 gag-polyprotein putative aspartyl protease Peptidase_A2E PF12382.8 EMD62740.1 - 0.22 11.5 0.1 0.7 9.9 0.0 1.8 2 0 0 2 2 2 0 Retrotransposon peptidase MIase PF02426.16 EMD62742.1 - 0.083 13.1 0.0 0.18 12.0 0.0 1.5 1 0 0 1 1 1 0 Muconolactone delta-isomerase Mgm101p PF06420.12 EMD62743.1 - 0.035 13.6 0.0 0.051 13.1 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial genome maintenance MGM101 Glyco_hydro_3_C PF01915.22 EMD62745.1 - 1.6e-40 139.3 0.0 3.4e-40 138.2 0.0 1.6 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 EMD62745.1 - 9.2e-33 114.0 0.0 1.8e-32 113.0 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 EMD62745.1 - 2.1e-22 79.0 0.0 4.4e-22 78.0 0.0 1.6 1 0 0 1 1 1 1 Fibronectin type III-like domain RTA1 PF04479.13 EMD62746.1 - 7.9e-61 205.3 17.0 1.2e-60 204.6 17.0 1.3 1 0 0 1 1 1 1 RTA1 like protein Glyco_transf_28 PF03033.20 EMD62747.1 - 2.2e-23 82.8 0.0 4.5e-23 81.8 0.0 1.6 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain UDPGT PF00201.18 EMD62747.1 - 0.0058 15.5 0.0 0.012 14.4 0.0 1.5 2 0 0 2 2 2 1 UDP-glucoronosyl and UDP-glucosyl transferase Zn_clus PF00172.18 EMD62748.1 - 1.3e-06 28.4 9.2 2.1e-06 27.7 9.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EMD62748.1 - 5.3e-06 25.5 0.2 7.3e-06 25.0 0.2 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain F-box-like PF12937.7 EMD62749.1 - 0.00045 20.0 0.1 0.00045 20.0 0.1 1.9 2 1 1 3 3 3 1 F-box-like DUF4949 PF16307.5 EMD62749.1 - 0.12 12.5 0.0 0.13 12.4 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4949) Ank_2 PF12796.7 EMD62750.1 - 9e-23 80.7 1.3 4.8e-14 52.7 0.1 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 EMD62750.1 - 2.3e-19 68.9 0.5 0.00055 20.3 0.0 4.1 4 0 0 4 4 4 4 Ankyrin repeat Ank_4 PF13637.6 EMD62750.1 - 8.5e-17 61.3 0.0 1e-06 29.2 0.0 3.0 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMD62750.1 - 1.2e-12 46.8 0.1 0.069 13.7 0.0 4.1 4 0 0 4 4 4 4 Ankyrin repeat Ank_5 PF13857.6 EMD62750.1 - 3.6e-09 36.7 0.5 0.0052 17.1 0.1 3.9 1 1 3 4 4 4 3 Ankyrin repeats (many copies) DUF4766 PF15973.5 EMD62750.1 - 0.01 16.4 2.7 0.31 11.6 1.3 2.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4766) Nitro_FeMo-Co PF02579.17 EMD62750.1 - 0.13 12.6 2.1 0.72 10.2 0.3 2.1 1 1 1 2 2 2 0 Dinitrogenase iron-molybdenum cofactor DUF1843 PF08898.10 EMD62750.1 - 1.9 9.0 4.4 17 6.0 0.3 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF1843) KR PF08659.10 EMD62751.1 - 1.3e-40 139.3 0.1 9e-39 133.2 0.1 2.1 1 1 0 1 1 1 1 KR domain adh_short PF00106.25 EMD62751.1 - 1.8e-09 37.4 0.1 2.2e-08 33.8 0.0 2.1 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD62751.1 - 5.8e-05 22.8 0.0 0.00012 21.7 0.0 1.5 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Polysacc_synt_2 PF02719.15 EMD62751.1 - 0.00096 18.4 0.0 0.0015 17.7 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein F420_oxidored PF03807.17 EMD62751.1 - 0.12 13.0 0.1 1.5 9.4 0.0 2.4 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent Aminotran_1_2 PF00155.21 EMD62752.1 - 4.9e-32 111.5 0.1 1.1e-28 100.5 0.0 2.5 3 0 0 3 3 3 2 Aminotransferase class I and II Aminotran_5 PF00266.19 EMD62752.1 - 0.0068 15.4 0.0 0.48 9.3 0.0 2.6 3 0 0 3 3 3 2 Aminotransferase class-V Beta_elim_lyase PF01212.21 EMD62752.1 - 0.043 13.1 0.0 0.29 10.4 0.0 1.9 1 1 0 1 1 1 0 Beta-eliminating lyase Fe-ADH PF00465.19 EMD62753.1 - 4.3e-13 48.8 0.0 4.9e-13 48.6 0.0 1.0 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Spc24 PF08286.11 EMD62753.1 - 0.14 12.5 0.0 0.19 12.0 0.0 1.3 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 Condensation PF00668.20 EMD62754.1 - 2.1e-11 43.2 0.0 3.2e-11 42.6 0.0 1.3 1 0 0 1 1 1 1 Condensation domain PS-DH PF14765.6 EMD62755.1 - 1.7e-65 221.2 0.0 2.6e-65 220.6 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase ketoacyl-synt PF00109.26 EMD62755.1 - 6.5e-58 196.3 1.4 7.8e-58 196.0 0.0 1.8 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 EMD62755.1 - 1.1e-56 192.7 0.0 1.8e-56 192.0 0.0 1.2 1 0 0 1 1 1 1 Acyl transferase domain KR PF08659.10 EMD62755.1 - 2.8e-56 190.3 0.5 6.8e-56 189.0 0.2 1.8 2 0 0 2 2 1 1 KR domain Ketoacyl-synt_C PF02801.22 EMD62755.1 - 3.1e-35 120.7 0.0 7e-35 119.6 0.0 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Methyltransf_12 PF08242.12 EMD62755.1 - 5.9e-21 75.1 0.0 3.9e-20 72.4 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain KAsynt_C_assoc PF16197.5 EMD62755.1 - 8.5e-17 61.6 3.5 7.4e-16 58.6 2.3 2.8 2 1 0 2 2 2 1 Ketoacyl-synthetase C-terminal extension ADH_zinc_N_2 PF13602.6 EMD62755.1 - 9.8e-15 55.8 0.0 3.4e-14 54.0 0.0 2.0 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 EMD62755.1 - 5e-12 45.9 0.0 1.5e-11 44.4 0.0 1.9 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Methyltransf_11 PF08241.12 EMD62755.1 - 2.5e-10 40.9 0.0 2.2e-09 37.8 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EMD62755.1 - 2.6e-10 40.4 0.0 5.7e-10 39.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain adh_short PF00106.25 EMD62755.1 - 2.8e-10 40.0 0.0 6.4e-10 38.8 0.0 1.6 1 0 0 1 1 1 1 short chain dehydrogenase Methyltransf_25 PF13649.6 EMD62755.1 - 1.3e-09 38.7 0.0 5.8e-09 36.5 0.0 2.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMD62755.1 - 7.4e-09 35.6 0.0 1.6e-08 34.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PP-binding PF00550.25 EMD62755.1 - 4.5e-07 30.1 1.8 5.4e-07 29.9 0.1 2.0 2 0 0 2 2 1 1 Phosphopantetheine attachment site adh_short_C2 PF13561.6 EMD62755.1 - 4.7e-05 23.1 0.0 8.9e-05 22.2 0.0 1.4 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase ADH_N PF08240.12 EMD62755.1 - 4.9e-05 23.2 0.2 0.00012 22.0 0.2 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Thiolase_N PF00108.23 EMD62755.1 - 0.0011 18.4 0.1 0.0023 17.4 0.1 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain SAT PF16073.5 EMD62755.1 - 0.029 14.1 0.2 0.31 10.7 0.1 2.3 2 0 0 2 2 2 0 Starter unit:ACP transacylase in aflatoxin biosynthesis Methyltransf_24 PF13578.6 EMD62755.1 - 0.065 14.3 0.0 1.3 10.1 0.0 3.0 2 0 0 2 2 2 0 Methyltransferase domain Ubie_methyltran PF01209.18 EMD62755.1 - 0.13 11.6 0.0 0.27 10.6 0.0 1.4 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family p450 PF00067.22 EMD62756.1 - 1.8e-65 221.5 0.0 2.6e-65 221.0 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 Flavodoxin_1 PF00258.25 EMD62756.1 - 4.1e-20 72.5 0.0 8e-20 71.5 0.0 1.5 1 0 0 1 1 1 1 Flavodoxin FAD_binding_1 PF00667.20 EMD62756.1 - 4.1e-19 69.0 0.0 8.2e-19 68.1 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.21 EMD62756.1 - 3.4e-09 37.3 0.0 6.5e-09 36.4 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Desulfoferrod_N PF06397.12 EMD62756.1 - 0.1 12.2 0.1 0.2 11.3 0.1 1.4 1 0 0 1 1 1 0 Desulfoferrodoxin, N-terminal domain Fungal_trans PF04082.18 EMD62757.1 - 0.00022 20.3 0.9 0.00049 19.2 0.0 2.0 3 0 0 3 3 3 1 Fungal specific transcription factor domain MAPEG PF01124.18 EMD62758.1 - 6.2e-22 77.9 0.4 7e-22 77.7 0.4 1.0 1 0 0 1 1 1 1 MAPEG family HTH_psq PF05225.16 EMD62759.1 - 2.3e-05 24.0 0.1 3.1e-05 23.6 0.1 1.2 1 0 0 1 1 1 1 helix-turn-helix, Psq domain p450 PF00067.22 EMD62761.1 - 1.6e-75 254.7 0.0 2e-75 254.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Waikav_capsid_1 PF12264.8 EMD62762.1 - 0.044 13.3 0.1 0.06 12.9 0.1 1.1 1 0 0 1 1 1 0 Waikavirus capsid protein 1 DUF4258 PF14076.6 EMD62763.1 - 0.077 13.4 0.3 0.11 12.8 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4258) QSregVF_b PF12843.7 EMD62763.1 - 0.15 11.9 0.0 0.31 11.0 0.0 1.4 1 0 0 1 1 1 0 Putative quorum-sensing-regulated virulence factor Cyclin PF08613.11 EMD62764.1 - 8e-09 36.1 0.0 1.4e-08 35.2 0.0 1.4 1 1 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 EMD62764.1 - 1.7e-07 31.0 0.0 2.9e-07 30.3 0.0 1.4 1 1 0 1 1 1 1 Cyclin, N-terminal domain Glyco_hydro_39 PF01229.17 EMD62765.1 - 0.13 10.9 0.1 0.17 10.5 0.1 1.1 1 0 0 1 1 1 0 Glycosyl hydrolases family 39 p450 PF00067.22 EMD62766.1 - 2.3e-57 194.8 0.0 6.1e-57 193.4 0.0 1.6 1 1 0 1 1 1 1 Cytochrome P450 Cmc1 PF08583.10 EMD62766.1 - 0.16 12.0 0.0 0.87 9.6 0.0 2.1 2 0 0 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like bZIP_Maf PF03131.17 EMD62767.1 - 0.18 12.3 13.5 0.35 11.4 13.5 1.4 1 0 0 1 1 1 0 bZIP Maf transcription factor bZIP_1 PF00170.21 EMD62767.1 - 0.6 10.3 15.3 1.9 8.6 15.3 1.9 1 1 0 1 1 1 0 bZIP transcription factor BDV_P24 PF06595.11 EMD62769.1 - 0.045 13.6 0.1 0.091 12.6 0.0 1.5 1 1 0 1 1 1 0 Borna disease virus P24 protein MerR-DNA-bind PF09278.11 EMD62770.1 - 0.25 11.9 4.7 0.4 11.3 3.8 1.7 2 0 0 2 2 2 0 MerR, DNA binding ALIX_LYPXL_bnd PF13949.6 EMD62772.1 - 0.0014 18.0 0.3 0.0017 17.7 0.3 1.1 1 0 0 1 1 1 1 ALIX V-shaped domain binding to HIV CLZ PF16526.5 EMD62772.1 - 0.002 18.5 0.1 0.0042 17.4 0.1 1.5 1 0 0 1 1 1 1 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF4763 PF15960.5 EMD62772.1 - 0.0038 16.6 0.3 0.0044 16.4 0.3 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4763) HOOK PF05622.12 EMD62772.1 - 0.004 15.4 0.3 0.0049 15.1 0.3 1.1 1 0 0 1 1 1 1 HOOK protein GDPD PF03009.17 EMD62772.1 - 0.028 14.1 0.4 0.081 12.6 0.4 1.6 1 1 1 2 2 2 0 Glycerophosphoryl diester phosphodiesterase family Isy1 PF06246.12 EMD62772.1 - 0.047 13.3 1.6 0.05 13.2 0.6 1.6 1 1 0 1 1 1 0 Isy1-like splicing family NAD_binding_4 PF07993.12 EMD62775.1 - 0.016 14.4 0.0 0.017 14.3 0.0 1.1 1 0 0 1 1 1 0 Male sterility protein Peptidase_S8 PF00082.22 EMD62777.1 - 2.4e-17 63.1 0.1 2.8e-17 62.9 0.1 1.0 1 0 0 1 1 1 1 Subtilase family RPT PF13446.6 EMD62777.1 - 0.034 14.1 0.0 0.061 13.2 0.0 1.3 1 0 0 1 1 1 0 A repeated domain in UCH-protein FAD_binding_4 PF01565.23 EMD62778.1 - 3.6e-20 72.1 0.1 9.3e-20 70.8 0.0 1.7 2 0 0 2 2 2 1 FAD binding domain BBE PF08031.12 EMD62778.1 - 0.047 13.8 0.1 0.097 12.8 0.1 1.6 1 0 0 1 1 1 0 Berberine and berberine like Catalase PF00199.19 EMD62779.1 - 3.1e-153 510.4 1.5 4e-153 510.1 1.5 1.1 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.12 EMD62779.1 - 9.1e-14 51.4 0.2 1.8e-13 50.4 0.2 1.6 1 0 0 1 1 1 1 Catalase-related immune-responsive Kelch_5 PF13854.6 EMD62780.1 - 2.8e-12 46.3 1.7 8.5e-10 38.4 0.1 2.9 2 0 0 2 2 2 2 Kelch motif Kelch_4 PF13418.6 EMD62780.1 - 0.00031 20.7 0.2 0.0045 17.0 0.1 3.0 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_3 PF13415.6 EMD62780.1 - 0.0023 18.2 7.6 0.016 15.5 0.1 4.3 3 1 0 3 3 3 1 Galactose oxidase, central domain SKG6 PF08693.10 EMD62780.1 - 0.046 13.1 0.4 0.092 12.2 0.4 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Kelch_6 PF13964.6 EMD62780.1 - 0.1 12.9 2.0 4.9 7.6 0.1 3.8 4 0 0 4 4 4 0 Kelch motif KdpA PF03814.15 EMD62780.1 - 0.11 10.6 0.1 0.16 10.1 0.1 1.1 1 0 0 1 1 1 0 Potassium-transporting ATPase A subunit MFS_1 PF07690.16 EMD62781.1 - 2.8e-12 46.2 31.5 2.8e-12 46.2 31.5 1.3 1 1 0 1 1 1 1 Major Facilitator Superfamily UNC-93 PF05978.16 EMD62781.1 - 1.5e-06 28.0 5.2 1.5e-06 28.0 5.2 2.2 2 0 0 2 2 2 1 Ion channel regulatory protein UNC-93 PUCC PF03209.15 EMD62781.1 - 5.9e-05 22.3 0.4 5.9e-05 22.3 0.4 2.2 3 0 0 3 3 3 1 PUCC protein DAO PF01266.24 EMD62782.1 - 2.6e-47 162.1 0.4 3.1e-47 161.9 0.4 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EMD62782.1 - 0.00034 20.0 0.1 0.0087 15.3 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EMD62782.1 - 0.0013 18.0 0.1 0.017 14.3 0.0 2.1 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.14 EMD62782.1 - 0.0098 15.1 0.0 2.8 7.1 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EMD62782.1 - 0.018 14.3 0.0 0.036 13.3 0.0 1.6 1 0 0 1 1 1 0 Thi4 family NAD_binding_9 PF13454.6 EMD62782.1 - 0.019 14.9 3.5 0.079 12.9 0.3 2.5 2 1 0 2 2 2 0 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 EMD62782.1 - 0.021 15.0 0.2 0.061 13.6 0.2 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 EMD62782.1 - 0.1 11.3 0.6 0.25 10.0 0.0 1.7 2 0 0 2 2 2 0 HI0933-like protein Shikimate_DH PF01488.20 EMD62782.1 - 0.15 12.1 0.0 0.36 10.9 0.0 1.6 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Fungal_trans PF04082.18 EMD62783.1 - 1.8e-24 86.2 0.1 2.8e-24 85.6 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD62783.1 - 6.2e-07 29.4 10.9 1.3e-06 28.4 10.9 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Hydrolase PF00702.26 EMD62784.1 - 0.00025 21.4 0.0 0.00068 20.0 0.0 1.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EMD62784.1 - 0.0025 17.9 0.0 0.0038 17.3 0.0 1.3 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase DAO PF01266.24 EMD62785.1 - 4.6e-31 108.7 0.7 5.8e-31 108.3 0.7 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EMD62785.1 - 3e-05 24.2 0.1 9e-05 22.6 0.0 1.8 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 EMD62785.1 - 0.00099 18.4 0.0 0.022 14.0 0.0 2.2 2 0 0 2 2 2 1 Thi4 family Pyr_redox_2 PF07992.14 EMD62785.1 - 0.0013 18.1 0.0 0.0024 17.1 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EMD62785.1 - 0.086 12.1 0.0 0.14 11.4 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain NAD_binding_9 PF13454.6 EMD62785.1 - 0.1 12.6 0.1 0.99 9.4 0.0 2.2 2 0 0 2 2 2 0 FAD-NAD(P)-binding DUF5557 PF17712.1 EMD62785.1 - 0.14 12.1 0.0 0.28 11.1 0.0 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5557) Pyr_redox_3 PF13738.6 EMD62785.1 - 0.15 11.3 0.0 3.8 6.7 0.0 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Latarcin PF10279.9 EMD62785.1 - 0.21 12.0 0.1 0.35 11.3 0.1 1.3 1 0 0 1 1 1 0 Latarcin precursor Methyltransf_23 PF13489.6 EMD62786.1 - 1.6e-19 70.3 0.0 2.4e-19 69.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMD62786.1 - 2.1e-13 50.8 0.0 5.9e-13 49.3 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMD62786.1 - 9.9e-12 45.4 0.0 2.1e-11 44.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMD62786.1 - 1.2e-08 35.5 0.0 7.7e-08 33.0 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMD62786.1 - 1.1e-06 28.6 0.0 0.02 14.7 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Ubie_methyltran PF01209.18 EMD62786.1 - 6.1e-05 22.5 0.0 0.00036 20.0 0.0 2.0 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 EMD62786.1 - 0.001 18.7 0.0 0.0087 15.6 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase small domain CMAS PF02353.20 EMD62786.1 - 0.0056 16.0 0.0 0.012 14.9 0.0 1.6 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_16 PF10294.9 EMD62786.1 - 0.0087 15.8 0.0 0.014 15.2 0.0 1.2 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_2 PF00891.18 EMD62786.1 - 0.02 14.2 0.0 0.047 13.0 0.0 1.6 2 0 0 2 2 2 0 O-methyltransferase domain PrmA PF06325.13 EMD62786.1 - 0.059 12.8 0.0 0.099 12.0 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Med13_C PF06333.12 EMD62786.1 - 0.068 12.4 1.0 0.084 12.1 1.0 1.1 1 0 0 1 1 1 0 Mediator complex subunit 13 C-terminal domain FAD_binding_3 PF01494.19 EMD62787.1 - 6.5e-20 71.7 3.7 4.7e-12 45.8 0.5 2.9 2 1 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 EMD62787.1 - 3.2e-06 27.3 0.8 1e-05 25.7 0.8 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EMD62787.1 - 4.1e-06 26.6 0.6 5.6e-06 26.2 0.6 1.5 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EMD62787.1 - 0.0001 21.5 0.2 0.00019 20.6 0.2 1.4 1 0 0 1 1 1 1 FAD binding domain Lycopene_cycl PF05834.12 EMD62787.1 - 0.003 16.7 0.1 0.069 12.2 0.1 2.4 3 0 0 3 3 3 1 Lycopene cyclase protein Pyr_redox_2 PF07992.14 EMD62787.1 - 0.0049 16.1 0.2 0.0087 15.3 0.2 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 EMD62787.1 - 0.0099 15.2 0.1 3.5 6.8 0.0 2.4 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase Pyr_redox PF00070.27 EMD62787.1 - 0.017 15.7 0.2 0.038 14.5 0.2 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EMD62787.1 - 0.027 13.7 0.2 0.041 13.1 0.2 1.2 1 0 0 1 1 1 0 Thi4 family Pyr_redox_3 PF13738.6 EMD62787.1 - 0.04 13.2 0.2 0.069 12.4 0.2 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 EMD62787.1 - 0.2 10.9 0.9 0.32 10.3 0.9 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Mycoplasma_p37 PF06646.11 EMD62788.1 - 0.19 11.0 0.0 0.19 11.0 0.0 1.2 1 0 0 1 1 1 0 High affinity transport system protein p37 ADH_N PF08240.12 EMD62789.1 - 5.4e-25 87.4 3.7 8.6e-25 86.7 3.7 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EMD62789.1 - 1.1e-18 67.5 0.0 1.9e-18 66.7 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EMD62789.1 - 1.2e-05 26.4 0.0 2.1e-05 25.6 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 EMD62789.1 - 0.00067 19.1 0.1 0.0012 18.2 0.1 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 EMD62789.1 - 0.0034 16.7 0.0 0.0054 16.1 0.0 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain TrkA_N PF02254.18 EMD62789.1 - 0.046 14.0 0.0 0.084 13.1 0.0 1.4 1 0 0 1 1 1 0 TrkA-N domain Shikimate_DH PF01488.20 EMD62789.1 - 0.057 13.5 0.0 0.22 11.6 0.0 1.8 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase PTPRCAP PF15713.5 EMD62790.1 - 0.00042 20.6 11.6 0.00042 20.6 11.6 1.7 2 0 0 2 2 2 1 Protein tyrosine phosphatase receptor type C-associated NOA36 PF06524.12 EMD62790.1 - 0.11 11.8 9.5 0.16 11.3 9.5 1.3 1 0 0 1 1 1 0 NOA36 protein RXT2_N PF08595.11 EMD62790.1 - 0.25 11.3 5.5 0.55 10.2 5.5 1.5 1 0 0 1 1 1 0 RXT2-like, N-terminal NUDIX_4 PF14815.6 EMD62790.1 - 0.3 11.1 3.0 0.65 10.0 3.0 1.5 1 0 0 1 1 1 0 NUDIX domain RNA_pol_3_Rpc31 PF11705.8 EMD62790.1 - 0.34 11.1 15.7 0.47 10.7 15.7 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 TFB6 PF17110.5 EMD62790.1 - 1 9.1 6.0 1.8 8.3 6.0 1.4 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH U1snRNP70_N PF12220.8 EMD62790.1 - 1.9 9.2 7.2 7.9 7.2 6.2 2.5 3 0 0 3 3 3 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF4207 PF13904.6 EMD62790.1 - 2.8 7.5 16.8 3.8 7.1 16.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4207) Nop14 PF04147.12 EMD62790.1 - 3.2 5.9 13.8 4 5.5 13.8 1.1 1 0 0 1 1 1 0 Nop14-like family DNA_pol_phi PF04931.13 EMD62790.1 - 4.1 5.4 14.4 5.4 5.0 14.4 1.1 1 0 0 1 1 1 0 DNA polymerase phi RPN2_C PF18004.1 EMD62790.1 - 5.9 6.8 8.7 9.1 6.2 8.7 1.3 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain DUF1738 PF08401.11 EMD62790.1 - 6.2 6.9 7.8 3.2 7.9 4.6 2.0 3 0 0 3 3 3 0 Domain of unknown function (DUF1738) p450 PF00067.22 EMD62791.1 - 1.6e-68 231.6 0.0 2e-68 231.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Methyltransf_25 PF13649.6 EMD62792.1 - 2.6e-19 69.7 0.0 6e-19 68.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMD62792.1 - 1.7e-16 60.6 0.0 3e-16 59.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMD62792.1 - 1.8e-15 57.1 0.0 2.4e-15 56.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMD62792.1 - 3.4e-14 53.4 0.0 6.4e-14 52.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EMD62792.1 - 1.3e-11 44.6 0.0 1.7e-11 44.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EMD62792.1 - 1e-07 31.7 0.0 1.6e-07 31.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_2 PF00891.18 EMD62792.1 - 1.4e-05 24.5 0.0 2.2e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain TehB PF03848.14 EMD62792.1 - 0.0026 17.2 0.0 0.0037 16.7 0.0 1.2 1 0 0 1 1 1 1 Tellurite resistance protein TehB FtsJ PF01728.19 EMD62792.1 - 0.0043 17.2 0.0 0.0052 16.9 0.0 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase NodS PF05401.11 EMD62792.1 - 0.013 15.1 0.0 0.017 14.7 0.0 1.1 1 0 0 1 1 1 0 Nodulation protein S (NodS) CheR PF01739.18 EMD62792.1 - 0.023 14.2 0.0 0.12 11.9 0.0 1.9 1 1 1 2 2 2 0 CheR methyltransferase, SAM binding domain Methyltransf_32 PF13679.6 EMD62792.1 - 0.037 14.0 0.0 0.05 13.6 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_4 PF02390.17 EMD62792.1 - 0.043 13.3 0.0 0.14 11.7 0.0 1.7 2 0 0 2 2 2 0 Putative methyltransferase PCMT PF01135.19 EMD62792.1 - 0.16 11.7 0.0 0.23 11.2 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) RhoGAP PF00620.27 EMD62793.1 - 7e-37 126.6 1.2 1.7e-36 125.3 0.5 2.0 2 0 0 2 2 2 1 RhoGAP domain LIM PF00412.22 EMD62793.1 - 2e-26 92.0 36.0 1.4e-11 44.4 5.2 5.1 5 0 0 5 5 5 4 LIM domain RNA_pol_Rpb4 PF03874.16 EMD62794.1 - 1.6e-15 57.5 0.5 2e-15 57.2 0.5 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb4 Tyrosinase PF00264.20 EMD62795.1 - 1.8e-37 129.8 2.0 2.7e-37 129.2 2.0 1.2 1 0 0 1 1 1 1 Common central domain of tyrosinase Tyosinase_C PF18132.1 EMD62795.1 - 5e-11 43.3 0.0 9.1e-11 42.5 0.0 1.4 1 0 0 1 1 1 1 Tyosinase C-terminal domain LANC_like PF05147.13 EMD62796.1 - 2.3e-30 105.4 0.0 2.4e-29 102.0 0.0 2.1 1 1 1 2 2 2 2 Lanthionine synthetase C-like protein RBR PF17208.3 EMD62799.1 - 0.054 14.2 5.7 0.067 13.9 5.7 1.3 1 0 0 1 1 1 0 RNA binding Region Clr5 PF14420.6 EMD62800.1 - 4.2e-17 62.1 0.1 1.7e-16 60.1 0.1 1.9 2 0 0 2 2 2 1 Clr5 domain Ank_4 PF13637.6 EMD62800.1 - 0.0013 19.3 0.0 0.0033 18.0 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 EMD62801.1 - 9.3e-31 105.8 2.3 1.3e-13 51.1 0.1 3.8 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 EMD62801.1 - 3.3e-26 91.7 2.8 8e-14 52.0 0.1 3.1 1 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EMD62801.1 - 1.1e-22 77.6 1.5 3.8e-05 23.7 0.0 5.1 5 0 0 5 5 5 4 Ankyrin repeat Ank PF00023.30 EMD62801.1 - 6.2e-14 51.7 9.6 5.5e-05 23.4 0.1 4.8 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 EMD62801.1 - 2.6e-12 46.7 6.6 0.0053 17.1 0.3 4.3 2 2 2 4 4 4 3 Ankyrin repeats (many copies) Fil_haemagg_2 PF13332.6 EMD62801.1 - 0.02 15.1 1.1 0.024 14.8 1.1 1.3 1 0 0 1 1 1 0 Hemagglutinin repeat 3HCDH_RFF PF18321.1 EMD62801.1 - 0.15 12.5 6.4 5 7.7 3.8 2.6 2 0 0 2 2 2 0 3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-fold domain EccE PF11203.8 EMD62801.1 - 2 8.8 10.3 0.55 10.6 5.9 2.1 1 1 1 2 2 2 0 Putative type VII ESX secretion system translocon, EccE APH PF01636.23 EMD62802.1 - 6.5e-11 42.6 0.0 1.1e-10 41.8 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family DUF1679 PF07914.11 EMD62802.1 - 0.0013 17.7 0.1 0.0023 16.9 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1679) EcKinase PF02958.20 EMD62802.1 - 0.0073 15.7 0.0 0.013 14.9 0.0 1.3 1 0 0 1 1 1 1 Ecdysteroid kinase Pkinase_Tyr PF07714.17 EMD62802.1 - 0.17 11.2 0.0 0.35 10.1 0.0 1.4 1 0 0 1 1 1 0 Protein tyrosine kinase p450 PF00067.22 EMD62803.1 - 1.9e-29 102.8 0.0 2.5e-24 85.9 0.0 2.0 1 1 1 2 2 2 2 Cytochrome P450 polyprenyl_synt PF00348.17 EMD62804.1 - 5.4e-13 48.6 0.0 7.1e-13 48.2 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase APH PF01636.23 EMD62805.1 - 3.5e-14 53.3 0.0 6.6e-14 52.4 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family DUF1679 PF07914.11 EMD62805.1 - 0.00047 19.1 0.0 0.00075 18.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1679) U79_P34 PF03064.16 EMD62806.1 - 0.031 13.6 3.0 0.032 13.6 3.0 1.1 1 0 0 1 1 1 0 HSV U79 / HCMV P34 MscS_TM PF12794.7 EMD62806.1 - 1.6 7.5 2.2 1.9 7.3 2.2 1.0 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 2OG-FeII_Oxy_2 PF13532.6 EMD62807.1 - 2.8e-28 99.5 0.0 3.5e-28 99.2 0.0 1.2 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Fungal_trans PF04082.18 EMD62808.1 - 1.2e-13 50.7 0.0 3.3e-13 49.3 0.0 1.6 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD62808.1 - 4.8e-07 29.8 12.0 9.4e-07 28.9 12.0 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain HSBP1 PF06825.12 EMD62808.1 - 0.059 13.2 0.1 0.16 11.9 0.1 1.7 1 0 0 1 1 1 0 Heat shock factor binding protein 1 adh_short PF00106.25 EMD62811.1 - 5e-17 62.0 0.0 6.4e-17 61.7 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD62811.1 - 4.8e-13 49.2 0.0 6.3e-13 48.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD62811.1 - 0.0071 16.3 0.0 0.0096 15.8 0.0 1.2 1 0 0 1 1 1 1 KR domain OKR_DC_1_N PF03709.15 EMD62811.1 - 0.037 14.3 0.0 0.063 13.6 0.0 1.3 1 0 0 1 1 1 0 Orn/Lys/Arg decarboxylase, N-terminal domain Lipase_GDSL_2 PF13472.6 EMD62811.1 - 0.047 14.1 0.1 0.077 13.4 0.1 1.4 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family Pirin PF02678.16 EMD62813.1 - 4.4e-30 103.8 0.0 9.8e-30 102.7 0.0 1.6 1 0 0 1 1 1 1 Pirin Pirin_C PF05726.13 EMD62813.1 - 3.7e-28 97.9 0.0 2.3e-26 92.2 0.0 2.3 2 0 0 2 2 2 1 Pirin C-terminal cupin domain Cupin_2 PF07883.11 EMD62813.1 - 1.5e-09 37.4 0.9 5.6e-06 26.0 0.8 2.5 2 0 0 2 2 2 2 Cupin domain Cupin_3 PF05899.12 EMD62813.1 - 0.00055 19.6 2.6 0.22 11.2 0.0 2.7 3 0 0 3 3 3 2 Protein of unknown function (DUF861) Dus PF01207.17 EMD62815.1 - 2.5e-47 161.5 0.0 1.2e-46 159.2 0.0 1.9 1 1 0 1 1 1 1 Dihydrouridine synthase (Dus) ADH_N_2 PF16884.5 EMD62816.1 - 5.1e-31 106.8 0.0 1.1e-30 105.7 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N PF00107.26 EMD62816.1 - 6.4e-20 71.5 0.0 1e-19 70.8 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EMD62816.1 - 7.6e-11 43.2 0.1 2.1e-10 41.8 0.0 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase RNA_pol_Rbc25 PF08292.12 EMD62817.1 - 5.8e-35 120.4 1.2 1e-34 119.5 1.2 1.4 1 0 0 1 1 1 1 RNA polymerase III subunit Rpc25 SHS2_Rpb7-N PF03876.17 EMD62817.1 - 3.4e-15 56.2 0.0 7.1e-15 55.1 0.0 1.5 2 0 0 2 2 2 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 PF00575.23 EMD62817.1 - 0.02 15.3 0.0 0.035 14.4 0.0 1.5 1 0 0 1 1 1 0 S1 RNA binding domain Ncstrn_small PF18266.1 EMD62817.1 - 0.097 12.7 0.0 0.14 12.2 0.0 1.2 1 0 0 1 1 1 0 Nicastrin small lobe NUFIP1 PF10453.9 EMD62818.1 - 1.7e-11 43.8 0.7 1.7e-11 43.8 0.7 2.1 2 0 0 2 2 2 1 Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) zf-CCCH PF00642.24 EMD62818.1 - 0.00021 21.1 1.4 0.00039 20.3 1.4 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Nop14 PF04147.12 EMD62818.1 - 0.0041 15.4 12.8 0.0072 14.6 12.8 1.3 1 0 0 1 1 1 1 Nop14-like family zf-CCCH_4 PF18044.1 EMD62818.1 - 0.03 14.1 2.9 0.05 13.4 2.9 1.4 1 0 0 1 1 1 0 CCCH-type zinc finger zf_CCCH_4 PF18345.1 EMD62818.1 - 0.071 13.2 5.2 0.12 12.4 5.2 1.4 1 0 0 1 1 1 0 Zinc finger domain Peptidase_S64 PF08192.11 EMD62818.1 - 0.11 10.9 6.8 0.19 10.2 6.8 1.3 1 0 0 1 1 1 0 Peptidase family S64 O-antigen_lig PF13425.6 EMD62818.1 - 0.57 8.9 2.6 0.81 8.4 2.6 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Cwf_Cwc_15 PF04889.12 EMD62818.1 - 1.3 8.7 21.8 0.85 9.3 16.6 2.2 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein PI3K_1B_p101 PF10486.9 EMD62818.1 - 1.9 6.2 7.5 2.7 5.7 7.5 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit MCM_bind PF09739.9 EMD62818.1 - 3.5 6.0 9.9 5.9 5.2 9.9 1.3 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor PI-PLC-X PF00388.19 EMD62819.1 - 4.8e-62 207.8 0.0 7e-62 207.3 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 EMD62819.1 - 2.8e-40 137.2 0.0 5.1e-40 136.4 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain C2 PF00168.30 EMD62819.1 - 3.7e-06 27.2 0.0 1.8e-05 25.0 0.0 2.1 2 0 0 2 2 2 1 C2 domain Arteri_nucleo PF01481.16 EMD62820.1 - 0.4 11.0 2.9 0.91 9.9 1.6 2.4 2 1 0 2 2 2 0 Arterivirus nucleocapsid protein Glyco_transf_34 PF05637.12 EMD62821.1 - 1.1e-13 51.5 0.0 8.4e-09 35.5 0.0 2.4 1 1 1 2 2 2 2 galactosyl transferase GMA12/MNN10 family FAM199X PF15814.5 EMD62821.1 - 0.15 11.1 1.7 2.1 7.3 0.0 2.2 2 0 0 2 2 2 0 Protein family FAM199X HlyIII PF03006.20 EMD62823.1 - 7.7e-53 179.5 21.7 9.2e-53 179.2 21.7 1.1 1 0 0 1 1 1 1 Haemolysin-III related DUF962 PF06127.11 EMD62823.1 - 0.097 12.8 5.5 0.43 10.7 3.7 2.6 1 1 0 1 1 1 0 Protein of unknown function (DUF962) PRA1 PF03208.19 EMD62823.1 - 5.6 6.6 10.7 0.037 13.7 1.8 2.0 3 0 0 3 3 3 0 PRA1 family protein TssN PF17555.2 EMD62823.1 - 7.3 5.9 12.4 8.3 5.7 6.1 2.6 2 1 1 3 3 3 0 Type VI secretion system, TssN ABM PF03992.16 EMD62824.1 - 5e-14 52.2 0.0 5.8e-14 52.0 0.0 1.1 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase Glyco_hydro_3_C PF01915.22 EMD62825.1 - 1.8e-39 135.9 0.0 2.9e-39 135.1 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 EMD62825.1 - 2.2e-34 119.3 0.0 3.3e-34 118.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain p450 PF00067.22 EMD62825.1 - 3.9e-12 45.7 0.1 6.1e-12 45.0 0.1 1.2 1 0 0 1 1 1 1 Cytochrome P450 Fn3-like PF14310.6 EMD62825.1 - 2.3e-06 27.6 0.0 5.4e-06 26.4 0.0 1.6 1 0 0 1 1 1 1 Fibronectin type III-like domain Lactamase_B PF00753.27 EMD62827.1 - 2e-07 31.2 2.9 3.2e-07 30.6 2.0 1.7 2 1 0 2 2 2 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EMD62827.1 - 0.00066 19.2 0.0 0.001 18.6 0.0 1.5 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 EMD62827.1 - 0.034 14.0 0.0 0.055 13.4 0.0 1.4 1 0 0 1 1 1 0 Beta-lactamase superfamily domain COesterase PF00135.28 EMD62828.1 - 4.9e-61 207.1 0.0 6.1e-61 206.8 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EMD62828.1 - 0.00037 20.4 1.1 0.0053 16.6 1.0 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold NAD_binding_10 PF13460.6 EMD62829.1 - 1.9e-11 44.2 0.0 3.1e-09 37.0 0.0 2.1 1 1 0 2 2 2 2 NAD(P)H-binding Epimerase PF01370.21 EMD62829.1 - 8.5e-05 22.1 0.0 0.00013 21.5 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EMD62829.1 - 0.0069 15.8 0.0 0.01 15.3 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_11 PF14833.6 EMD62830.1 - 2.2e-26 92.5 0.0 3.5e-26 91.8 0.0 1.3 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase NAD_binding_2 PF03446.15 EMD62830.1 - 5.8e-10 39.6 0.0 8.5e-05 22.8 0.0 2.3 1 1 1 2 2 2 2 NAD binding domain of 6-phosphogluconate dehydrogenase CoA_trans PF01144.23 EMD62832.1 - 1.5e-95 318.7 4.7 9.1e-57 191.9 0.6 2.4 2 0 0 2 2 2 2 Coenzyme A transferase Fe-ADH PF00465.19 EMD62832.1 - 6.6e-69 232.5 0.8 1.2e-68 231.6 0.8 1.3 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 EMD62832.1 - 8.8e-18 64.9 0.0 1.7e-17 63.9 0.0 1.4 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase PFK PF00365.20 EMD62832.1 - 0.065 12.5 0.2 0.15 11.4 0.2 1.5 1 0 0 1 1 1 0 Phosphofructokinase Thiolase_N PF00108.23 EMD62833.1 - 3.3e-72 243.0 0.2 3.2e-71 239.8 0.1 1.9 2 0 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EMD62833.1 - 1.3e-42 144.3 0.1 1.3e-41 141.1 0.1 2.1 2 0 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 EMD62833.1 - 2e-05 24.3 1.3 5.8e-05 22.8 0.9 2.0 1 1 1 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Lyase_1 PF00206.20 EMD62834.1 - 1.3e-45 156.1 0.0 3.2e-45 154.9 0.0 1.5 1 1 0 1 1 1 1 Lyase ADSL_C PF10397.9 EMD62834.1 - 8.1e-21 74.4 0.1 2e-19 69.9 0.0 2.6 2 0 0 2 2 2 1 Adenylosuccinate lyase C-terminus HgmA PF04209.13 EMD62835.1 - 2.8e-141 471.1 0.0 3.3e-141 470.8 0.0 1.0 1 0 0 1 1 1 1 homogentisate 1,2-dioxygenase CoA_transf_3 PF02515.17 EMD62836.1 - 1.4e-125 419.3 0.0 1.6e-125 419.1 0.0 1.0 1 0 0 1 1 1 1 CoA-transferase family III Fungal_trans PF04082.18 EMD62837.1 - 1e-11 44.4 0.3 2.4e-11 43.2 0.3 1.7 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-H2C2_2 PF13465.6 EMD62837.1 - 2.9e-05 24.3 7.9 2.9e-05 24.3 7.9 2.9 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2 PF00096.26 EMD62837.1 - 0.001 19.4 17.8 0.04 14.4 4.1 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMD62837.1 - 0.0028 18.3 15.0 0.22 12.5 3.0 2.9 2 0 0 2 2 2 2 C2H2-type zinc finger zf-met PF12874.7 EMD62837.1 - 0.11 12.9 16.6 0.2 12.1 1.3 3.5 3 0 0 3 3 3 0 Zinc-finger of C2H2 type C1_4 PF07975.12 EMD62837.1 - 0.31 11.3 3.7 0.68 10.2 3.7 1.6 1 0 0 1 1 1 0 TFIIH C1-like domain Zn-ribbon_8 PF09723.10 EMD62837.1 - 0.6 10.3 3.9 1.6 8.9 3.9 1.7 1 0 0 1 1 1 0 Zinc ribbon domain zf-C2H2_jaz PF12171.8 EMD62837.1 - 1.2 9.5 18.4 0.085 13.2 1.1 3.5 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 EMD62837.1 - 4 7.6 11.1 1.7 8.7 3.9 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger p450 PF00067.22 EMD62838.1 - 1.2e-70 238.5 0.0 1.6e-70 238.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 DUF1155 PF06633.11 EMD62838.1 - 0.0095 15.4 0.1 0.027 13.9 0.1 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1155) DUF924 PF06041.11 EMD62839.1 - 5.3e-48 163.5 0.0 6.3e-48 163.3 0.0 1.1 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF924) HSCB_C PF07743.13 EMD62843.1 - 2.4e-21 76.0 11.1 2.4e-21 76.0 11.1 1.9 2 0 0 2 2 2 1 HSCB C-terminal oligomerisation domain DnaJ PF00226.31 EMD62843.1 - 2.4e-06 27.6 0.3 6e-06 26.3 0.3 1.6 1 0 0 1 1 1 1 DnaJ domain adh_short_C2 PF13561.6 EMD62844.1 - 3.4e-27 95.5 0.0 1.3e-26 93.6 0.0 1.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EMD62844.1 - 1e-20 74.0 0.0 2.1e-20 73.0 0.0 1.4 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EMD62844.1 - 0.059 13.3 0.0 0.13 12.2 0.0 1.5 2 0 0 2 2 2 0 KR domain dCMP_cyt_deam_1 PF00383.23 EMD62845.1 - 8.7e-08 32.0 0.2 1.5e-07 31.2 0.2 1.4 1 1 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region LmjF365940-deam PF14421.6 EMD62845.1 - 0.016 14.8 2.0 0.36 10.4 0.2 2.1 1 1 1 2 2 2 0 A distinct subfamily of CDD/CDA-like deaminases dCMP_cyt_deam_2 PF08211.12 EMD62845.1 - 0.14 12.4 0.2 2.4 8.4 0.0 2.2 2 0 0 2 2 2 0 Cytidine and deoxycytidylate deaminase zinc-binding region FAD_binding_3 PF01494.19 EMD62846.1 - 2e-17 63.5 0.2 2.5e-16 59.9 0.2 2.0 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.24 EMD62846.1 - 1.3e-05 24.9 9.9 0.0064 16.1 0.1 2.4 2 1 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EMD62846.1 - 2.7e-05 23.5 0.3 0.0046 16.2 0.2 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EMD62846.1 - 0.0004 19.6 6.3 0.00048 19.3 4.9 1.8 2 0 0 2 2 2 1 FAD binding domain Lycopene_cycl PF05834.12 EMD62846.1 - 0.00089 18.4 3.3 0.01 14.9 3.3 2.1 1 1 0 1 1 1 1 Lycopene cyclase protein FAD_oxidored PF12831.7 EMD62846.1 - 0.0013 18.2 4.2 0.0021 17.5 4.2 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 EMD62846.1 - 0.0019 17.0 2.2 0.016 13.9 2.0 1.9 2 0 0 2 2 2 1 HI0933-like protein NAD_binding_8 PF13450.6 EMD62846.1 - 0.0069 16.6 4.8 0.017 15.3 3.5 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 EMD62846.1 - 0.015 14.4 1.8 0.021 14.0 1.8 1.1 1 0 0 1 1 1 0 Glucose inhibited division protein A Thi4 PF01946.17 EMD62846.1 - 0.021 14.1 0.4 0.038 13.2 0.4 1.3 1 0 0 1 1 1 0 Thi4 family Trp_halogenase PF04820.14 EMD62846.1 - 0.054 12.3 4.0 0.11 11.3 0.6 2.1 1 1 0 2 2 2 0 Tryptophan halogenase Rossmann-like PF10727.9 EMD62846.1 - 0.08 12.8 0.2 0.17 11.8 0.2 1.4 1 0 0 1 1 1 0 Rossmann-like domain Pyr_redox PF00070.27 EMD62846.1 - 0.13 12.8 1.8 0.56 10.8 0.8 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EMD62846.1 - 0.14 11.4 0.2 0.22 10.7 0.2 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 EMD62846.1 - 0.48 10.3 1.9 0.98 9.3 1.9 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Amidase PF01425.21 EMD62847.1 - 1.5e-86 291.2 0.0 2e-86 290.8 0.0 1.2 1 0 0 1 1 1 1 Amidase FAD_binding_3 PF01494.19 EMD62848.1 - 6.1e-80 269.1 0.0 7.6e-80 268.8 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Phe_hydrox_dim PF07976.12 EMD62848.1 - 9.1e-29 100.6 0.0 1.9e-28 99.6 0.0 1.5 1 0 0 1 1 1 1 Phenol hydroxylase, C-terminal dimerisation domain Pyr_redox_2 PF07992.14 EMD62848.1 - 2.5e-05 23.7 0.1 0.00034 20.0 0.0 2.3 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EMD62848.1 - 0.00074 18.3 0.1 0.0015 17.3 0.1 1.5 2 0 0 2 2 2 1 HI0933-like protein Lycopene_cycl PF05834.12 EMD62848.1 - 0.001 18.2 0.1 0.0016 17.6 0.1 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox PF00070.27 EMD62848.1 - 0.0054 17.3 0.0 0.049 14.2 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EMD62848.1 - 0.0074 15.9 0.1 0.27 10.8 0.0 2.2 1 1 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.17 EMD62848.1 - 0.0084 15.4 0.0 0.017 14.4 0.0 1.4 1 0 0 1 1 1 1 Thi4 family NAD_binding_8 PF13450.6 EMD62848.1 - 0.0095 16.2 0.1 0.023 14.9 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain TrkA_N PF02254.18 EMD62848.1 - 0.043 14.1 0.0 0.17 12.1 0.0 2.0 2 0 0 2 2 2 0 TrkA-N domain AlaDh_PNT_C PF01262.21 EMD62848.1 - 0.051 12.9 0.0 0.09 12.1 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Rep_1B PF17873.1 EMD62848.1 - 0.056 13.3 0.0 0.2 11.6 0.0 1.9 1 0 0 1 1 1 0 Replicase polyprotein 1ab Pyr_redox_3 PF13738.6 EMD62848.1 - 0.11 11.7 0.0 0.19 10.9 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EMD62848.1 - 0.16 11.0 0.0 0.3 10.1 0.0 1.4 1 0 0 1 1 1 0 FAD binding domain Shikimate_DH PF01488.20 EMD62848.1 - 0.2 11.7 0.0 0.52 10.4 0.0 1.7 2 0 0 2 2 1 0 Shikimate / quinate 5-dehydrogenase Ald_Xan_dh_C2 PF02738.18 EMD62849.1 - 1.9e-198 660.4 0.0 2.7e-198 659.9 0.0 1.1 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase FAD_binding_5 PF00941.21 EMD62849.1 - 1.3e-38 132.4 0.0 2.6e-38 131.4 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain in molybdopterin dehydrogenase CO_deh_flav_C PF03450.17 EMD62849.1 - 6.9e-34 116.1 0.0 3.6e-33 113.8 0.0 2.2 2 0 0 2 2 2 1 CO dehydrogenase flavoprotein C-terminal domain Ald_Xan_dh_C PF01315.22 EMD62849.1 - 5.7e-32 110.4 0.0 1.3e-31 109.2 0.0 1.7 1 0 0 1 1 1 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain Fer2_2 PF01799.20 EMD62849.1 - 5.1e-25 87.3 0.1 1.5e-24 85.8 0.1 1.9 1 0 0 1 1 1 1 [2Fe-2S] binding domain Fer2 PF00111.27 EMD62849.1 - 6.9e-08 32.3 0.0 2.3e-07 30.7 0.0 2.0 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain DHODB_Fe-S_bind PF10418.9 EMD62849.1 - 0.055 13.3 1.0 0.16 11.8 1.0 1.7 1 0 0 1 1 1 0 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B Spherulin4 PF12138.8 EMD62850.1 - 3.2e-66 223.4 0.0 3.6e-66 223.2 0.0 1.0 1 0 0 1 1 1 1 Spherulation-specific family 4 MFS_1 PF07690.16 EMD62851.1 - 2e-26 92.8 10.8 2.3e-26 92.5 7.9 2.1 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EMD62851.1 - 0.0019 17.2 2.1 0.0019 17.2 2.1 2.3 2 1 0 2 2 2 1 Sugar (and other) transporter GATase PF00117.28 EMD62852.1 - 2.6e-10 40.4 0.0 7.4e-10 38.9 0.0 1.7 1 1 1 2 2 2 1 Glutamine amidotransferase class-I Phage_CP76 PF06892.11 EMD62852.1 - 0.19 11.2 0.0 0.31 10.6 0.0 1.3 1 0 0 1 1 1 0 Phage regulatory protein CII (CP76) Beta_elim_lyase PF01212.21 EMD62853.1 - 2.7e-70 237.0 0.0 3.4e-70 236.7 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.20 EMD62853.1 - 0.0019 16.8 0.0 0.0038 15.8 0.0 1.4 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 EMD62853.1 - 0.043 13.0 0.0 0.059 12.5 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class I and II FSH1 PF03959.13 EMD62854.1 - 3.8e-29 101.9 0.0 4.7e-29 101.6 0.0 1.1 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_2 PF02230.16 EMD62854.1 - 0.031 14.1 0.0 2.6 7.8 0.0 2.7 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase Abhydrolase_1 PF00561.20 EMD62854.1 - 0.082 12.5 0.0 0.15 11.7 0.0 1.4 1 1 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_3 PF07859.13 EMD62854.1 - 0.11 12.4 0.1 0.34 10.7 0.0 1.8 2 0 0 2 2 2 0 alpha/beta hydrolase fold HET PF06985.11 EMD62855.1 - 1.2e-29 103.5 0.0 1.6e-29 103.1 0.0 1.2 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Nuc_deoxyri_tr2 PF15891.5 EMD62855.1 - 0.01 16.1 0.0 0.014 15.7 0.0 1.1 1 0 0 1 1 1 0 Nucleoside 2-deoxyribosyltransferase like W2 PF02020.18 EMD62855.1 - 0.11 12.7 0.0 0.17 12.1 0.0 1.3 1 0 0 1 1 1 0 eIF4-gamma/eIF5/eIF2-epsilon Glutaredoxin PF00462.24 EMD62856.1 - 1.3e-19 70.1 0.0 1.2e-17 63.9 0.0 2.9 2 1 1 3 3 3 1 Glutaredoxin Thioredoxin PF00085.20 EMD62856.1 - 2.6e-14 53.1 0.0 5.4e-14 52.0 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 EMD62856.1 - 0.0092 16.3 0.1 0.93 9.9 0.0 2.4 1 1 1 2 2 2 1 Thioredoxin-like Thioredoxin_2 PF13098.6 EMD62856.1 - 0.03 14.8 0.0 0.12 12.8 0.0 2.0 2 0 0 2 2 2 0 Thioredoxin-like domain DUF3801 PF12687.7 EMD62856.1 - 0.051 13.6 0.0 0.073 13.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3801) OST3_OST6 PF04756.13 EMD62856.1 - 0.094 12.0 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family Brix PF04427.18 EMD62857.1 - 1.3e-40 139.6 1.3 1.8e-40 139.1 1.3 1.2 1 0 0 1 1 1 1 Brix domain MMS19_C PF12460.8 EMD62858.1 - 4e-108 362.2 6.6 4.8e-104 348.8 2.8 4.9 4 1 0 4 4 4 2 RNAPII transcription regulator C-terminal MMS19_N PF14500.6 EMD62858.1 - 3.7e-98 328.3 0.1 4.4e-95 318.2 0.0 3.6 3 1 0 3 3 3 2 Dos2-interacting transcription regulator of RNA-Pol-II HEAT_2 PF13646.6 EMD62858.1 - 2.7e-05 24.5 7.4 0.13 12.7 0.2 6.0 7 0 0 7 7 7 2 HEAT repeats HEAT_EZ PF13513.6 EMD62858.1 - 0.0028 18.1 9.9 0.12 12.9 0.4 5.8 6 1 0 6 6 6 1 HEAT-like repeat HSR PF03172.13 EMD62858.1 - 0.052 13.7 0.0 0.19 11.9 0.0 1.9 1 0 0 1 1 1 0 HSR domain RTP1_C1 PF10363.9 EMD62858.1 - 0.15 12.2 0.7 5 7.3 0.0 3.7 4 0 0 4 4 4 0 Required for nuclear transport of RNA pol II C-terminus 1 HEAT PF02985.22 EMD62858.1 - 0.66 10.4 8.0 24 5.5 0.1 6.0 7 0 0 7 7 7 0 HEAT repeat Cnd1 PF12717.7 EMD62858.1 - 2.5 8.1 6.9 54 3.8 0.1 5.3 7 1 0 7 7 7 0 non-SMC mitotic condensation complex subunit 1 THF_DHG_CYH PF00763.23 EMD62859.1 - 1.6e-22 79.9 0.0 2.6e-22 79.3 0.0 1.3 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain THF_DHG_CYH_C PF02882.19 EMD62859.1 - 3.8e-13 49.1 0.0 2.5e-09 36.6 0.0 2.6 2 1 0 2 2 2 2 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain F-box PF00646.33 EMD62860.1 - 0.0021 17.9 0.0 0.0043 16.9 0.0 1.5 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EMD62860.1 - 0.11 12.5 0.2 0.21 11.5 0.2 1.5 1 0 0 1 1 1 0 F-box-like SH3_9 PF14604.6 EMD62861.1 - 7.3e-29 99.4 4.7 4.8e-15 55.1 0.3 2.5 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.28 EMD62861.1 - 8.3e-25 86.1 3.2 8e-13 47.8 0.1 2.5 2 0 0 2 2 2 2 SH3 domain Cofilin_ADF PF00241.20 EMD62861.1 - 9.5e-16 57.7 0.0 1.8e-15 56.8 0.0 1.4 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein SH3_2 PF07653.17 EMD62861.1 - 6.1e-13 48.3 0.0 2.1e-05 24.1 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain GIT_CC PF16559.5 EMD62862.1 - 0.0046 16.8 3.4 0.0046 16.8 3.4 3.7 4 1 0 4 4 4 1 GIT coiled-coil Rho guanine nucleotide exchange factor CsiV PF10972.8 EMD62862.1 - 0.0048 16.6 0.9 0.0088 15.8 0.9 1.5 1 1 0 1 1 1 1 Peptidoglycan-binding protein, CsiV ATG16 PF08614.11 EMD62862.1 - 0.024 14.9 32.8 0.29 11.3 14.8 2.7 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Fez1 PF06818.15 EMD62862.1 - 0.036 14.5 30.0 0.04 14.4 7.8 2.4 1 1 1 2 2 2 0 Fez1 Ribonucleas_3_2 PF11469.8 EMD62862.1 - 0.038 14.4 0.3 0.18 12.2 0.0 2.1 2 0 0 2 2 2 0 Ribonuclease III Phage_GP20 PF06810.11 EMD62862.1 - 0.041 13.7 12.8 0.07 12.9 0.9 3.3 3 1 0 3 3 3 0 Phage minor structural protein GP20 DUF1664 PF07889.12 EMD62862.1 - 0.11 12.5 11.4 0.028 14.4 2.4 3.0 2 2 0 2 2 2 0 Protein of unknown function (DUF1664) XkdW PF09636.10 EMD62862.1 - 0.16 12.0 2.5 4.4 7.5 0.2 2.7 2 0 0 2 2 2 0 XkdW protein Myosin_tail_1 PF01576.19 EMD62862.1 - 0.37 8.5 33.5 0.42 8.4 14.8 2.1 1 1 1 2 2 2 0 Myosin tail GAS PF13851.6 EMD62862.1 - 0.99 8.7 25.2 2.1 7.7 6.9 2.3 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding Sporozoite_P67 PF05642.11 EMD62862.1 - 1 7.3 8.7 1.5 6.8 8.7 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen FlaC_arch PF05377.11 EMD62862.1 - 1.5 9.3 9.0 4.3 7.8 0.4 4.8 4 1 1 5 5 5 0 Flagella accessory protein C (FlaC) ERM PF00769.19 EMD62862.1 - 2.2 8.0 33.6 8.7 6.1 16.0 2.3 1 1 1 2 2 2 0 Ezrin/radixin/moesin family CALCOCO1 PF07888.11 EMD62862.1 - 2.6 6.8 36.6 0.59 8.9 30.5 1.9 1 1 1 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like Spc7 PF08317.11 EMD62862.1 - 2.8 6.7 27.5 6.7 5.5 13.1 2.3 1 1 1 2 2 2 0 Spc7 kinetochore protein Rx_N PF18052.1 EMD62862.1 - 3.5 8.0 13.3 1.7 9.0 0.5 3.7 3 2 0 3 3 3 0 Rx N-terminal domain DASH_Dam1 PF08653.10 EMD62862.1 - 3.9 7.3 6.2 8.1 6.3 0.6 3.5 4 0 0 4 4 3 0 DASH complex subunit Dam1 CHDCT2 PF08074.11 EMD62862.1 - 4.5 7.4 11.6 1.8 8.7 3.0 2.6 1 1 0 2 2 2 0 CHDCT2 (NUC038) domain DUF3138 PF11336.8 EMD62862.1 - 7.5 5.0 6.4 0.92 8.1 0.8 2.1 1 1 2 3 3 3 0 Protein of unknown function (DUF3138) DivIC PF04977.15 EMD62862.1 - 8.3 6.3 18.4 1.3 8.9 1.6 4.2 3 2 2 5 5 5 0 Septum formation initiator BTB PF00651.31 EMD62863.1 - 7.3e-12 45.5 0.0 1.6e-11 44.4 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain DUF2373 PF10180.9 EMD62863.1 - 0.11 12.3 0.1 0.36 10.7 0.0 1.9 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2373) Chlorophyllase2 PF12740.7 EMD62865.1 - 1.1e-05 24.5 0.0 1.6e-05 24.0 0.0 1.1 1 0 0 1 1 1 1 Chlorophyllase enzyme DLH PF01738.18 EMD62865.1 - 0.00063 19.4 0.0 0.00086 18.9 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family GPI-anchored PF10342.9 EMD62866.1 - 3.1e-14 53.5 0.5 3.1e-14 53.5 0.5 2.0 2 1 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family SOG2 PF10428.9 EMD62866.1 - 0.77 8.9 14.7 0.84 8.8 14.7 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Macoilin PF09726.9 EMD62866.1 - 3.8 6.0 10.4 4.4 5.7 10.4 1.0 1 0 0 1 1 1 0 Macoilin family SPX PF03105.19 EMD62866.1 - 5.7 6.8 9.2 6.2 6.6 9.2 1.1 1 0 0 1 1 1 0 SPX domain SET PF00856.28 EMD62868.1 - 1.8e-10 41.5 0.1 1.1e-09 38.9 0.0 2.3 2 2 0 2 2 2 1 SET domain zf-MYND PF01753.18 EMD62868.1 - 1.5e-07 31.4 13.7 1.5e-07 31.4 13.7 2.5 2 1 0 2 2 2 1 MYND finger Isochorismatase PF00857.20 EMD62870.1 - 1.7e-26 93.5 0.0 3.4e-26 92.5 0.0 1.5 1 1 0 1 1 1 1 Isochorismatase family PBP PF01161.20 EMD62870.1 - 3.1e-19 69.6 0.1 5.7e-19 68.7 0.1 1.4 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein DUF5541 PF17695.1 EMD62870.1 - 0.11 13.0 0.1 0.34 11.4 0.0 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5541) Dynamin_M PF01031.20 EMD62871.1 - 2e-109 365.3 0.0 3.4e-109 364.5 0.0 1.4 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.23 EMD62871.1 - 8.1e-57 191.9 0.0 1.9e-56 190.8 0.0 1.6 1 0 0 1 1 1 1 Dynamin family GED PF02212.18 EMD62871.1 - 7.2e-32 109.4 2.1 1.9e-31 108.1 2.1 1.8 1 0 0 1 1 1 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 EMD62871.1 - 4.8e-05 23.4 0.3 0.00065 19.8 0.3 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EMD62871.1 - 0.12 11.9 0.1 11 5.5 0.0 2.4 2 0 0 2 2 2 0 Ferrous iron transport protein B ATP-synt_E PF05680.12 EMD62872.1 - 3.5e-22 78.6 0.1 3.9e-22 78.4 0.1 1.0 1 0 0 1 1 1 1 ATP synthase E chain WD40 PF00400.32 EMD62873.1 - 8.4e-09 35.9 4.1 0.14 13.1 0.1 5.9 6 0 0 6 6 6 3 WD domain, G-beta repeat Pilosulin PF17499.2 EMD62876.1 - 0.035 14.3 0.1 1.3 9.3 0.0 2.3 2 0 0 2 2 2 0 Ant venom peptides Peptidase_S10 PF00450.22 EMD62877.1 - 1.3e-91 308.1 4.1 1.7e-91 307.7 4.1 1.2 1 0 0 1 1 1 1 Serine carboxypeptidase RNase_H PF00075.24 EMD62878.1 - 2.3e-05 24.6 0.4 4.6e-05 23.6 0.1 1.7 2 0 0 2 2 2 1 RNase H DUF5112 PF17139.4 EMD62878.1 - 0.036 13.5 0.1 0.053 13.0 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5112) Gryzun-like PF12742.7 EMD62878.1 - 0.082 12.9 0.0 0.14 12.2 0.0 1.3 1 0 0 1 1 1 0 Gryzun, putative Golgi trafficking DUF4939 PF16297.5 EMD62880.1 - 0.0094 15.8 0.0 0.01 15.7 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4939) Njmu-R1 PF15053.6 EMD62882.1 - 0.026 13.7 0.0 0.028 13.6 0.0 1.0 1 0 0 1 1 1 0 Mjmu-R1-like protein family ADH_N PF08240.12 EMD62886.1 - 5.4e-25 87.4 2.1 6.2e-25 87.2 1.0 1.7 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EMD62886.1 - 7.4e-21 74.5 0.0 1.1e-20 74.0 0.0 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EMD62886.1 - 2.8e-13 49.8 0.0 4e-13 49.4 0.0 1.2 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 EMD62886.1 - 1e-05 26.6 0.0 1.8e-05 25.8 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 EMD62886.1 - 0.018 14.4 0.0 0.028 13.8 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Sacchrp_dh_NADP PF03435.18 EMD62886.1 - 0.05 13.9 0.0 0.11 12.8 0.0 1.6 1 1 1 2 2 2 0 Saccharopine dehydrogenase NADP binding domain TrkA_N PF02254.18 EMD62886.1 - 0.16 12.2 0.0 0.36 11.1 0.0 1.6 1 0 0 1 1 1 0 TrkA-N domain ThiF PF00899.21 EMD62886.1 - 0.25 10.6 1.1 0.49 9.7 0.0 1.9 3 0 0 3 3 3 0 ThiF family Abhydrolase_3 PF07859.13 EMD62887.1 - 6e-52 176.6 0.0 7.9e-52 176.2 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 EMD62887.1 - 3.3e-09 36.2 0.2 1.3e-08 34.2 0.2 1.7 1 1 0 1 1 1 1 Carboxylesterase family Abhydro_lipase PF04083.16 EMD62887.1 - 0.00017 21.1 0.0 0.00032 20.2 0.0 1.3 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Peptidase_S9 PF00326.21 EMD62887.1 - 0.0018 17.8 0.0 0.13 11.7 0.0 2.2 2 0 0 2 2 2 1 Prolyl oligopeptidase family Say1_Mug180 PF10340.9 EMD62887.1 - 0.0018 17.2 0.0 0.0031 16.5 0.0 1.3 1 1 0 1 1 1 1 Steryl acetyl hydrolase Hydrolase_4 PF12146.8 EMD62887.1 - 0.071 12.4 0.1 0.14 11.4 0.0 1.6 2 0 0 2 2 2 0 Serine aminopeptidase, S33 DLH PF01738.18 EMD62887.1 - 0.08 12.5 0.0 1.1 8.8 0.0 2.2 2 0 0 2 2 2 0 Dienelactone hydrolase family Abhydrolase_6 PF12697.7 EMD62887.1 - 0.15 12.6 7.0 0.45 11.1 7.0 1.6 1 1 0 1 1 1 0 Alpha/beta hydrolase family AXE1 PF05448.12 EMD62887.1 - 0.21 10.2 0.1 0.57 8.8 0.0 1.7 2 0 0 2 2 2 0 Acetyl xylan esterase (AXE1) FMO-like PF00743.19 EMD62888.1 - 1.4e-13 50.1 0.0 1.1e-11 43.9 0.0 2.2 2 0 0 2 2 2 1 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.6 EMD62888.1 - 2.6e-11 43.6 0.0 3.8e-08 33.4 0.0 2.6 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 EMD62888.1 - 6.7e-11 41.9 0.0 3.9e-08 32.8 0.0 3.0 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.14 EMD62888.1 - 7.5e-11 41.8 0.0 1.6e-09 37.4 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EMD62888.1 - 3.9e-10 39.5 0.0 1e-07 31.5 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EMD62888.1 - 0.00011 21.5 1.1 0.013 14.8 0.1 2.8 3 0 0 3 3 3 1 Thi4 family Pyr_redox PF00070.27 EMD62888.1 - 0.00013 22.5 3.9 0.27 11.8 0.0 3.5 5 0 0 5 5 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EMD62888.1 - 0.00061 19.5 4.1 0.11 12.1 0.3 3.9 2 1 1 3 3 3 1 FAD dependent oxidoreductase NAD_binding_2 PF03446.15 EMD62888.1 - 0.00064 19.9 0.0 0.0083 16.3 0.0 2.2 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase ApbA PF02558.16 EMD62888.1 - 0.00092 18.9 0.3 0.22 11.1 0.0 2.5 2 0 0 2 2 2 1 Ketopantoate reductase PanE/ApbA NAD_binding_9 PF13454.6 EMD62888.1 - 0.0012 18.9 0.4 0.5 10.3 0.0 3.3 3 1 0 3 3 3 1 FAD-NAD(P)-binding Lycopene_cycl PF05834.12 EMD62888.1 - 0.0028 16.8 0.0 2 7.4 0.0 2.2 2 0 0 2 2 2 2 Lycopene cyclase protein Shikimate_DH PF01488.20 EMD62888.1 - 0.0088 16.1 0.0 0.63 10.1 0.0 3.0 3 0 0 3 3 3 1 Shikimate / quinate 5-dehydrogenase NAD_binding_7 PF13241.6 EMD62888.1 - 0.019 15.4 0.1 0.2 12.1 0.0 2.4 2 1 0 2 2 1 0 Putative NAD(P)-binding GIDA PF01134.22 EMD62888.1 - 0.042 12.9 0.2 0.81 8.7 0.1 2.6 3 0 0 3 3 3 0 Glucose inhibited division protein A HI0933_like PF03486.14 EMD62888.1 - 0.044 12.5 0.4 1 8.0 0.1 2.3 2 0 0 2 2 2 0 HI0933-like protein 2-Hacid_dh_C PF02826.19 EMD62888.1 - 0.057 12.8 0.0 0.14 11.5 0.0 1.6 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ThiF PF00899.21 EMD62888.1 - 0.082 12.2 0.1 2 7.7 0.1 2.2 2 0 0 2 2 2 0 ThiF family AlaDh_PNT_C PF01262.21 EMD62888.1 - 0.083 12.2 0.1 0.28 10.5 0.0 1.8 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_2 PF00890.24 EMD62888.1 - 0.1 11.6 0.2 0.3 10.1 0.0 1.8 2 0 0 2 2 2 0 FAD binding domain DDE_1 PF03184.19 EMD62890.1 - 1.6e-30 106.0 0.0 2e-30 105.7 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.6 EMD62890.1 - 9.4e-08 31.9 0.1 3.5e-06 26.8 0.1 2.2 2 0 0 2 2 2 2 DDE superfamily endonuclease RVT_1 PF00078.27 EMD62891.1 - 3.6e-13 49.6 3.2 3.8e-13 49.5 3.2 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) K_oxygenase PF13434.6 EMD62894.1 - 1.1e-06 28.0 0.0 2e-05 23.9 0.0 2.1 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.14 EMD62894.1 - 2.1e-06 27.2 0.0 0.0018 17.5 0.0 2.8 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EMD62894.1 - 8.2e-06 26.0 0.0 9.3e-05 22.6 0.0 2.6 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FMO-like PF00743.19 EMD62894.1 - 5e-05 21.9 0.0 0.001 17.6 0.0 2.2 2 0 0 2 2 2 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EMD62894.1 - 0.0031 16.8 0.4 0.29 10.3 0.0 3.5 3 1 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Shikimate_DH PF01488.20 EMD62894.1 - 0.0045 17.0 0.0 0.034 14.2 0.0 2.2 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase NAD_binding_9 PF13454.6 EMD62894.1 - 0.036 14.0 0.0 28 4.6 0.0 3.7 4 0 0 4 4 4 0 FAD-NAD(P)-binding LpxK PF02606.14 EMD62896.1 - 0.0062 15.7 0.1 0.0076 15.4 0.1 1.1 1 0 0 1 1 1 1 Tetraacyldisaccharide-1-P 4'-kinase SUR7 PF06687.12 EMD62897.1 - 3.7e-43 147.6 3.0 4.4e-43 147.4 3.0 1.0 1 0 0 1 1 1 1 SUR7/PalI family Fig1 PF12351.8 EMD62897.1 - 3.2e-06 27.2 2.2 3.2e-06 27.2 2.2 1.5 2 0 0 2 2 2 1 Ca2+ regulator and membrane fusion protein Fig1 LYRIC PF15686.5 EMD62897.1 - 0.048 13.2 0.1 0.065 12.8 0.1 1.2 1 0 0 1 1 1 0 Lysine-rich CEACAM1 co-isolated protein family DUF5527 PF17665.1 EMD62897.1 - 0.22 11.0 1.4 0.75 9.3 0.7 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5527) DUF4389 PF14333.6 EMD62897.1 - 0.27 11.2 12.3 0.74 9.8 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4389) TssO PF17561.2 EMD62897.1 - 4.4 7.4 6.7 1.2 9.2 0.0 2.9 3 1 0 3 3 3 0 Type VI secretion system, TssO Amastin PF07344.11 EMD62897.1 - 6.9 6.5 12.4 0.92 9.3 7.4 1.9 2 0 0 2 2 2 0 Amastin surface glycoprotein EF-hand_1 PF00036.32 EMD62900.1 - 5.2e-28 94.5 1.2 4.3e-07 29.0 0.1 5.2 5 0 0 5 5 5 4 EF hand EF-hand_6 PF13405.6 EMD62900.1 - 1.9e-24 83.5 3.8 2.4e-05 23.9 0.0 5.2 5 0 0 5 5 5 4 EF-hand domain EF-hand_8 PF13833.6 EMD62900.1 - 7.5e-23 80.1 1.3 1.7e-11 43.8 0.0 4.2 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_7 PF13499.6 EMD62900.1 - 1.6e-21 76.5 6.2 1.5e-09 38.1 0.0 3.6 4 0 0 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.6 EMD62900.1 - 4.3e-18 63.9 4.1 0.00072 18.9 0.0 4.6 5 0 0 5 5 5 4 EF hand GUN4 PF05419.12 EMD62900.1 - 0.1 12.7 0.0 0.51 10.4 0.0 1.9 2 0 0 2 2 2 0 GUN4-like SRF-TF PF00319.18 EMD62901.1 - 3.9e-24 83.9 0.2 6e-24 83.3 0.2 1.3 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) FAM60A PF15396.6 EMD62901.1 - 1 9.3 6.4 2 8.4 6.4 1.5 1 0 0 1 1 1 0 Protein Family FAM60A Sin_N PF04801.13 EMD62901.1 - 3.3 6.8 26.1 5.4 6.1 26.1 1.2 1 0 0 1 1 1 0 Sin-like protein conserved region SLC12 PF03522.15 EMD62901.1 - 5.2 6.0 10.8 7.1 5.5 10.8 1.2 1 0 0 1 1 1 0 Solute carrier family 12 Bul1_N PF04425.12 EMD62901.1 - 7.9 5.1 13.4 12 4.5 13.4 1.3 1 0 0 1 1 1 0 Bul1 N terminus DUF1708 PF08101.11 EMD62903.1 - 4.5e-173 576.4 0.8 6e-173 575.9 0.0 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF1708) Med11 PF10280.9 EMD62904.1 - 0.03 14.8 3.3 0.1 13.1 3.3 1.9 1 0 0 1 1 1 0 Mediator complex protein DUF2205 PF10224.9 EMD62904.1 - 3.4 7.7 7.8 11 6.0 0.1 3.5 3 0 0 3 3 3 0 Short coiled-coil protein DUF2688 PF10892.8 EMD62905.1 - 0.083 12.4 0.3 0.2 11.1 0.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2688) STT3 PF02516.14 EMD62906.1 - 3.7e-144 481.3 33.7 1.9e-139 465.8 31.5 2.1 2 0 0 2 2 2 2 Oligosaccharyl transferase STT3 subunit zf-C2H2 PF00096.26 EMD62907.1 - 2.4e-05 24.5 33.3 0.1 13.1 0.8 7.0 6 0 0 6 6 6 5 Zinc finger, C2H2 type zf-C2H2_8 PF15909.5 EMD62907.1 - 2.9 8.2 11.9 0.91 9.9 3.8 3.2 2 1 0 2 2 2 0 C2H2-type zinc ribbon zf-C2H2_6 PF13912.6 EMD62907.1 - 6.1 7.0 8.0 18 5.5 0.5 3.6 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2 PF00096.26 EMD62908.1 - 0.0015 18.9 25.4 0.096 13.2 0.3 4.6 4 0 0 4 4 4 4 Zinc finger, C2H2 type FOXP-CC PF16159.5 EMD62908.1 - 1 10.1 13.0 0.58 10.8 1.3 3.2 2 1 1 3 3 3 0 FOXP coiled-coil domain Toxin_11 PF07473.11 EMD62908.1 - 1.8 8.7 4.5 12 6.1 0.0 3.3 3 0 0 3 3 3 0 Spasmodic peptide gm9a; conotoxin from Conus species SPC25 PF06703.11 EMD62911.1 - 7.7e-55 185.1 0.0 9.2e-55 184.9 0.0 1.1 1 0 0 1 1 1 1 Microsomal signal peptidase 25 kDa subunit (SPC25) EMC3_TMCO1 PF01956.16 EMD62912.1 - 1.2e-57 194.4 2.3 1.6e-57 194.0 2.3 1.2 1 0 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like EI24 PF07264.11 EMD62912.1 - 0.016 15.4 0.0 0.034 14.4 0.0 1.5 1 1 0 1 1 1 0 Etoposide-induced protein 2.4 (EI24) Macoilin PF09726.9 EMD62913.1 - 0.00077 18.2 3.2 0.00096 17.8 3.2 1.1 1 0 0 1 1 1 1 Macoilin family zf-C2H2_4 PF13894.6 EMD62913.1 - 0.21 12.5 0.3 0.21 12.5 0.3 4.9 3 1 0 3 3 3 0 C2H2-type zinc finger Apt1 PF10351.9 EMD62913.1 - 0.21 10.4 5.7 0.27 10.0 5.7 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Presenilin PF01080.17 EMD62913.1 - 2.2 7.0 4.2 3 6.5 4.2 1.2 1 0 0 1 1 1 0 Presenilin zf-C2H2_jaz PF12171.8 EMD62913.1 - 9.5 6.6 12.5 2.6 8.4 1.1 3.5 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.26 EMD62913.1 - 9.8 6.9 16.2 0.75 10.4 0.2 3.9 3 1 0 3 3 3 0 Zinc finger, C2H2 type PRKCSH PF07915.13 EMD62914.1 - 1.4e-19 70.9 0.1 1.4e-19 70.9 0.1 2.6 2 1 0 2 2 2 1 Glucosidase II beta subunit-like protein PRKCSH_1 PF13015.6 EMD62914.1 - 0.003 17.3 0.7 0.013 15.2 0.0 2.3 3 0 0 3 3 3 1 Glucosidase II beta subunit-like protein DNA_pol_B_thumb PF14791.6 EMD62914.1 - 0.19 11.9 3.7 0.2 11.8 1.4 2.2 2 0 0 2 2 2 0 DNA polymerase beta thumb HET PF06985.11 EMD62915.1 - 5.5e-28 98.2 0.0 1.3e-27 96.9 0.0 1.7 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Pkinase PF00069.25 EMD62916.1 - 6.1e-69 232.3 0.0 9.4e-69 231.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD62916.1 - 1.5e-38 132.6 0.0 2.5e-38 131.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.26 EMD62916.1 - 4.7e-09 36.5 0.5 7.7e-08 32.6 0.1 2.6 2 0 0 2 2 2 1 FHA domain Kdo PF06293.14 EMD62916.1 - 7.6e-05 22.2 0.1 0.00013 21.4 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Yop-YscD_cpl PF16697.5 EMD62916.1 - 0.0013 19.0 0.0 0.0032 17.8 0.0 1.6 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain Pkinase_fungal PF17667.1 EMD62916.1 - 0.023 13.5 0.0 0.042 12.6 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase RIO1 PF01163.22 EMD62916.1 - 0.046 13.3 0.3 0.085 12.4 0.3 1.3 1 0 0 1 1 1 0 RIO1 family FTA2 PF13095.6 EMD62916.1 - 0.075 12.6 0.1 0.16 11.6 0.1 1.5 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 EMD62916.1 - 0.11 12.3 0.1 6.1 6.7 0.1 2.4 1 1 1 2 2 2 0 Phosphotransferase enzyme family Rho_GDI PF02115.17 EMD62916.1 - 0.34 10.6 2.3 0.58 9.9 2.3 1.3 1 0 0 1 1 1 0 RHO protein GDP dissociation inhibitor Rabaptin PF03528.15 EMD62917.1 - 0.071 11.8 0.0 0.081 11.6 0.0 1.0 1 0 0 1 1 1 0 Rabaptin Pkinase PF00069.25 EMD62918.1 - 8.1e-61 205.7 0.0 4.2e-39 134.5 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EMD62918.1 - 2.2e-27 96.0 0.0 4.4e-21 75.3 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Response_reg PF00072.24 EMD62918.1 - 1.2e-13 51.1 0.0 2.5e-13 50.2 0.0 1.5 1 0 0 1 1 1 1 Response regulator receiver domain Kinase-like PF14531.6 EMD62918.1 - 3.9e-07 29.7 0.0 0.00024 20.5 0.0 2.2 2 0 0 2 2 2 2 Kinase-like APH PF01636.23 EMD62918.1 - 1.7e-05 24.8 0.0 0.001 19.1 0.1 2.5 1 1 1 2 2 2 1 Phosphotransferase enzyme family PAS PF00989.25 EMD62918.1 - 5e-05 23.3 0.0 0.00018 21.5 0.0 1.9 2 0 0 2 2 2 1 PAS fold PAS_9 PF13426.7 EMD62918.1 - 0.0092 16.2 0.0 0.028 14.7 0.0 1.7 1 0 0 1 1 1 1 PAS domain Haspin_kinase PF12330.8 EMD62918.1 - 0.023 13.7 0.0 0.039 12.9 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain PAS_4 PF08448.10 EMD62918.1 - 0.061 13.6 0.0 0.23 11.7 0.0 2.0 1 0 0 1 1 1 0 PAS fold Kdo PF06293.14 EMD62918.1 - 0.15 11.4 0.0 0.29 10.5 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Rax2 PF12768.7 EMD62919.1 - 0.01 15.3 0.5 0.013 14.9 0.5 1.2 1 0 0 1 1 1 1 Cortical protein marker for cell polarity Macoilin PF09726.9 EMD62919.1 - 0.012 14.2 1.8 0.011 14.4 1.8 1.1 1 0 0 1 1 1 0 Macoilin family Apt1 PF10351.9 EMD62919.1 - 0.019 13.9 1.5 0.017 14.0 1.5 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain CCDC106 PF15794.5 EMD62919.1 - 0.072 12.8 12.2 0.093 12.4 12.2 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 SR-25 PF10500.9 EMD62919.1 - 0.098 12.3 17.6 0.12 11.9 17.6 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Dicty_REP PF05086.12 EMD62919.1 - 0.21 9.5 4.5 0.21 9.6 4.5 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF1180 PF06679.12 EMD62919.1 - 0.44 11.0 9.9 0.64 10.4 9.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) DUF3464 PF11947.8 EMD62919.1 - 0.61 9.8 6.0 0.91 9.3 6.0 1.3 1 1 0 1 1 1 0 Photosynthesis affected mutant 68 NPR3 PF03666.13 EMD62919.1 - 1 8.1 5.5 1.2 7.9 5.5 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 FSA_C PF10479.9 EMD62919.1 - 1.7 6.7 9.5 2.1 6.4 9.5 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus SWI-SNF_Ssr4 PF08549.10 EMD62919.1 - 1.7 7.2 5.9 1.8 7.1 5.9 1.0 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) Hva1_TUDOR PF11160.8 EMD62920.1 - 1.4e-14 54.0 2.6 4.4e-14 52.4 2.6 1.9 1 0 0 1 1 1 1 Hypervirulence associated proteins TUDOR domain Integrin_b_cyt PF08725.11 EMD62920.1 - 0.21 11.3 0.9 0.57 9.9 0.9 1.8 1 0 0 1 1 1 0 Integrin beta cytoplasmic domain Glyco_hydro_38N PF01074.22 EMD62921.1 - 3.2e-87 292.6 0.2 7.4e-87 291.4 0.1 1.7 2 0 0 2 2 2 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.13 EMD62921.1 - 8.6e-56 189.4 0.1 6.2e-55 186.6 0.0 2.3 2 0 0 2 2 2 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.11 EMD62921.1 - 1.3e-28 98.9 0.0 3.5e-28 97.6 0.0 1.8 1 0 0 1 1 1 1 Alpha mannosidase middle domain Glyco_hydro38C2 PF17677.1 EMD62921.1 - 0.0001 22.4 0.0 0.00043 20.4 0.0 2.1 1 1 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal beta sandwich domain Glyco_hydro_57 PF03065.15 EMD62921.1 - 0.11 11.6 0.0 0.2 10.8 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 57 SVS_QK PF10578.9 EMD62922.1 - 0.053 14.1 0.5 0.28 11.8 0.5 2.3 1 0 0 1 1 1 0 Seminal vesicle protein repeat V-SNARE_C PF12352.8 EMD62922.1 - 4.3 7.7 7.3 4.8 7.5 0.8 2.4 2 0 0 2 2 2 0 Snare region anchored in the vesicle membrane C-terminus VIT1 PF01988.19 EMD62922.1 - 6.6 6.5 7.4 6.5 6.5 0.2 2.4 2 1 0 2 2 2 0 VIT family GDP_Man_Dehyd PF16363.5 EMD62923.1 - 3e-70 237.2 0.0 3.6e-70 237.0 0.0 1.1 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 EMD62923.1 - 6e-57 192.9 0.0 7.3e-57 192.6 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 EMD62923.1 - 9e-21 74.2 0.0 1.1e-20 73.9 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain 3Beta_HSD PF01073.19 EMD62923.1 - 1e-20 73.9 0.0 1.3e-20 73.5 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 EMD62923.1 - 2e-20 73.1 0.0 2e-19 69.8 0.0 2.0 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 EMD62923.1 - 1.5e-14 53.8 0.1 5.1e-13 48.8 0.1 2.2 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.6 EMD62923.1 - 9.1e-05 22.4 0.0 0.00012 22.0 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding adh_short PF00106.25 EMD62923.1 - 0.0026 17.2 0.0 0.019 14.4 0.0 2.1 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EMD62923.1 - 0.21 11.5 0.0 0.38 10.6 0.0 1.4 1 0 0 1 1 1 0 KR domain p450 PF00067.22 EMD62924.1 - 4.4e-63 213.6 0.0 5.1e-63 213.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 ketoacyl-synt PF00109.26 EMD62925.1 - 3e-75 253.1 0.0 3.9e-74 249.4 0.0 2.3 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain SAT PF16073.5 EMD62925.1 - 1.2e-50 172.6 0.2 2.7e-49 168.1 0.0 2.4 2 0 0 2 2 2 1 Starter unit:ACP transacylase in aflatoxin biosynthesis Acyl_transf_1 PF00698.21 EMD62925.1 - 4.7e-43 147.9 0.0 1.3e-42 146.5 0.0 1.8 2 0 0 2 2 2 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EMD62925.1 - 4.5e-32 110.5 0.3 1.3e-31 109.1 0.3 1.9 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain PS-DH PF14765.6 EMD62925.1 - 6.3e-13 48.6 0.0 1.1e-12 47.9 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase PP-binding PF00550.25 EMD62925.1 - 1.3e-12 47.9 0.3 3.2e-12 46.6 0.3 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site KAsynt_C_assoc PF16197.5 EMD62925.1 - 1.6e-09 38.2 0.0 3.8e-09 37.0 0.0 1.7 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Thiolase_N PF00108.23 EMD62925.1 - 1.5e-05 24.5 0.1 4.1e-05 23.1 0.1 1.6 1 0 0 1 1 1 1 Thiolase, N-terminal domain Lactamase_B PF00753.27 EMD62926.1 - 1.2e-14 54.8 0.4 8.3e-13 48.8 0.4 2.2 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EMD62926.1 - 3.7e-05 23.3 0.0 6.4e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 EMD62926.1 - 0.014 15.3 0.0 0.043 13.7 0.0 1.8 1 1 0 1 1 1 0 Beta-lactamase superfamily domain BLACT_WH PF17778.1 EMD62926.1 - 0.034 14.1 0.0 0.096 12.7 0.0 1.8 1 0 0 1 1 1 0 Beta-lactamase associated winged helix domain DUF1772 PF08592.11 EMD62927.1 - 9.9e-28 97.2 0.6 1.4e-27 96.7 0.6 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1772) DUF1772 PF08592.11 EMD62928.1 - 2.6e-14 53.7 3.5 4e-14 53.1 3.5 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1772) Scytalone_dh PF02982.14 EMD62929.1 - 5.1e-59 198.6 0.2 5.9e-59 198.4 0.2 1.0 1 0 0 1 1 1 1 Scytalone dehydratase SnoaL_4 PF13577.6 EMD62929.1 - 3e-05 24.1 0.7 7.2e-05 22.9 0.7 1.6 1 1 0 1 1 1 1 SnoaL-like domain NAD_binding_10 PF13460.6 EMD62930.1 - 1.6e-19 70.5 0.0 1.9e-19 70.2 0.0 1.1 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EMD62930.1 - 1.4e-05 24.7 0.0 2.7e-05 23.9 0.0 1.4 2 0 0 2 2 2 1 NmrA-like family 3Beta_HSD PF01073.19 EMD62930.1 - 0.0003 19.9 0.0 0.00037 19.6 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EMD62930.1 - 0.0045 16.5 0.0 0.0064 16.0 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EMD62930.1 - 0.023 13.8 0.0 0.034 13.3 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Semialdhyde_dh PF01118.24 EMD62930.1 - 0.024 15.1 0.0 0.036 14.5 0.0 1.4 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain adh_short_C2 PF13561.6 EMD62931.1 - 4.5e-54 183.5 0.9 6.1e-54 183.1 0.9 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EMD62931.1 - 1.7e-48 164.7 0.5 2e-48 164.4 0.5 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EMD62931.1 - 5.9e-12 45.9 0.5 8.1e-12 45.4 0.5 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EMD62931.1 - 0.0026 17.3 0.8 0.0089 15.5 0.8 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 2-Hacid_dh_C PF02826.19 EMD62931.1 - 0.033 13.6 0.1 0.055 12.8 0.1 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Peripla_BP_6 PF13458.6 EMD62931.1 - 0.074 12.7 0.4 0.16 11.6 0.4 1.5 1 0 0 1 1 1 0 Periplasmic binding protein DUF1776 PF08643.10 EMD62931.1 - 0.18 11.2 0.0 0.27 10.5 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) ABC2_membrane PF01061.24 EMD62932.1 - 6.6e-80 267.5 47.2 1.1e-45 155.6 14.3 2.5 3 0 0 3 3 2 2 ABC-2 type transporter ABC_tran PF00005.27 EMD62932.1 - 4.3e-37 127.7 0.0 8.6e-19 68.4 0.0 2.5 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.12 EMD62932.1 - 2.4e-21 75.4 0.2 9.2e-19 67.1 0.0 3.2 2 0 0 2 2 2 1 CDR ABC transporter ABC2_membrane_3 PF12698.7 EMD62932.1 - 7.8e-10 38.4 26.2 5.8e-06 25.6 9.6 2.5 2 0 0 2 2 2 2 ABC-2 family transporter protein AAA_16 PF13191.6 EMD62932.1 - 8.4e-07 29.5 0.1 0.0033 17.8 0.1 2.4 2 0 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 EMD62932.1 - 0.0001 22.6 0.3 0.89 9.8 0.0 2.8 2 1 0 2 2 2 2 AAA domain AAA_28 PF13521.6 EMD62932.1 - 0.00045 20.5 1.0 1 9.6 0.6 2.6 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.6 EMD62932.1 - 0.00081 19.1 0.3 0.081 12.7 0.1 2.7 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_33 PF13671.6 EMD62932.1 - 0.00095 19.3 0.0 0.63 10.2 0.0 2.4 2 0 0 2 2 2 2 AAA domain cobW PF02492.19 EMD62932.1 - 0.0013 18.3 0.9 1.5 8.4 0.0 2.3 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain RsgA_GTPase PF03193.16 EMD62932.1 - 0.0016 18.4 0.4 0.011 15.7 0.1 2.2 2 0 0 2 2 2 1 RsgA GTPase AAA_25 PF13481.6 EMD62932.1 - 0.0024 17.5 0.2 0.03 13.9 0.1 2.2 2 0 0 2 2 2 1 AAA domain ABC_trans_N PF14510.6 EMD62932.1 - 0.0041 17.7 0.1 0.015 15.9 0.1 2.0 1 0 0 1 1 1 1 ABC-transporter N-terminal AAA_18 PF13238.6 EMD62932.1 - 0.0059 17.2 0.0 2.9 8.4 0.0 2.6 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 EMD62932.1 - 0.013 15.4 0.4 3 7.8 0.1 2.4 2 0 0 2 2 2 0 NACHT domain AAA_30 PF13604.6 EMD62932.1 - 0.03 14.0 0.5 5.3 6.7 0.5 2.3 2 0 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 EMD62932.1 - 0.033 14.1 0.1 0.37 10.7 0.0 2.2 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA PF00004.29 EMD62932.1 - 0.097 13.1 0.2 15 6.0 0.0 2.5 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.12 EMD62932.1 - 0.11 11.8 0.2 6.4 6.0 0.1 2.3 2 0 0 2 2 2 0 Zeta toxin PduV-EutP PF10662.9 EMD62932.1 - 0.12 12.1 0.8 9.2 6.0 0.2 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_21 PF13304.6 EMD62932.1 - 0.16 11.8 0.0 5.5 6.7 0.0 2.5 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system OrfB_Zn_ribbon PF07282.11 EMD62932.1 - 0.2 11.6 0.0 0.4 10.7 0.0 1.5 1 0 0 1 1 1 0 Putative transposase DNA-binding domain Zn_clus PF00172.18 EMD62933.1 - 2e-05 24.6 18.8 2e-05 24.6 18.8 2.4 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain IL7 PF01415.16 EMD62933.1 - 0.0031 17.5 2.2 0.0052 16.8 1.1 1.9 2 0 0 2 2 2 1 Interleukin 7/9 family SPX PF03105.19 EMD62933.1 - 1.8 8.4 6.9 3.8 7.3 7.0 1.5 1 1 0 1 1 1 0 SPX domain EthD PF07110.11 EMD62934.1 - 7.3e-20 71.9 0.1 9.8e-20 71.5 0.1 1.2 1 0 0 1 1 1 1 EthD domain MmlI PF09448.10 EMD62934.1 - 0.0011 19.4 0.0 0.0017 18.8 0.0 1.3 1 0 0 1 1 1 1 Methylmuconolactone methyl-isomerase Ribosomal_L26 PF16906.5 EMD62934.1 - 0.067 13.7 0.0 0.072 13.6 0.0 1.2 1 0 0 1 1 1 0 Ribosomal proteins L26 eukaryotic, L24P archaeal FAD_binding_3 PF01494.19 EMD62936.1 - 4e-69 233.5 0.0 5.1e-69 233.2 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.27 EMD62936.1 - 0.16 12.5 0.1 22 5.7 0.0 2.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Helo_like_N PF17111.5 EMD62937.1 - 3.2e-08 33.2 0.8 6.9e-08 32.1 0.3 1.8 2 0 0 2 2 2 1 Fungal N-terminal domain of STAND proteins Ank_2 PF12796.7 EMD62937.1 - 1.1e-06 29.1 0.0 3.6e-06 27.5 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMD62937.1 - 2.9e-05 24.5 0.0 7.7e-05 23.2 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMD62937.1 - 0.0035 17.7 0.0 0.017 15.6 0.0 2.3 2 0 0 2 2 2 1 Ankyrin repeat Ank_5 PF13857.6 EMD62937.1 - 0.0045 17.3 0.0 0.011 16.0 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) SesA PF17107.5 EMD62937.1 - 0.039 14.2 0.1 0.11 12.7 0.0 1.8 1 1 0 1 1 1 0 N-terminal domain on NACHT_NTPase and P-loop NTPases Ank PF00023.30 EMD62937.1 - 0.045 14.2 0.1 0.15 12.6 0.1 2.0 1 0 0 1 1 1 0 Ankyrin repeat OGG_N PF07934.12 EMD62938.1 - 1.7e-34 118.5 0.0 3.9e-34 117.3 0.0 1.6 2 0 0 2 2 2 1 8-oxoguanine DNA glycosylase, N-terminal domain HhH-GPD PF00730.25 EMD62938.1 - 4.7e-15 56.0 0.0 8.8e-15 55.1 0.0 1.4 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 EMD62938.1 - 4.4e-05 23.1 0.0 9.4e-05 22.1 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix motif Tnp_22_trimer PF17489.2 EMD62938.1 - 0.75 9.8 5.6 2.3 8.2 5.6 1.9 1 0 0 1 1 1 0 L1 transposable element trimerization domain RRM_1 PF00076.22 EMD62939.1 - 1.6e-27 95.1 0.1 1.4e-10 40.8 0.0 3.8 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EMD62939.1 - 0.00016 21.5 0.1 0.088 12.7 0.1 3.2 3 0 0 3 3 3 2 Occluded RNA-recognition motif adh_short PF00106.25 EMD62940.1 - 6.3e-19 68.2 0.3 6.2e-18 65.0 0.2 2.0 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD62940.1 - 2.3e-08 33.9 0.0 1.1e-07 31.6 0.0 1.8 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD62940.1 - 2e-07 31.1 0.2 3.1e-07 30.5 0.2 1.2 1 0 0 1 1 1 1 KR domain Shikimate_DH PF01488.20 EMD62940.1 - 0.12 12.5 0.1 0.2 11.7 0.1 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Sugar_tr PF00083.24 EMD62943.1 - 2.1e-129 432.3 20.2 2.4e-129 432.1 20.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD62943.1 - 1.3e-22 80.3 23.6 1.3e-22 80.3 23.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily dUTPase PF00692.19 EMD62945.1 - 9.9e-39 132.0 0.0 1.2e-38 131.7 0.0 1.1 1 0 0 1 1 1 1 dUTPase ECH_1 PF00378.20 EMD62945.1 - 0.018 14.4 0.3 0.023 14.0 0.3 1.2 1 0 0 1 1 1 0 Enoyl-CoA hydratase/isomerase Phos_pyr_kin PF08543.12 EMD62946.1 - 2.5e-09 36.9 0.0 4.1e-09 36.2 0.0 1.4 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase PfkB PF00294.24 EMD62946.1 - 9.8e-06 25.1 0.1 3.5e-05 23.3 0.0 2.0 3 0 0 3 3 3 1 pfkB family carbohydrate kinase PCNA_N PF00705.18 EMD62947.1 - 1.7e-53 179.7 3.3 1.7e-53 179.7 3.3 1.9 3 0 0 3 3 3 1 Proliferating cell nuclear antigen, N-terminal domain PCNA_C PF02747.15 EMD62947.1 - 4.8e-53 178.7 0.0 3.1e-52 176.1 0.0 1.9 2 0 0 2 2 2 1 Proliferating cell nuclear antigen, C-terminal domain Rad9 PF04139.13 EMD62947.1 - 1.6e-07 31.1 0.0 1.9e-07 30.8 0.0 1.1 1 0 0 1 1 1 1 Rad9 Rad1 PF02144.16 EMD62947.1 - 1.1e-05 24.6 0.1 0.015 14.3 0.0 2.1 1 1 1 2 2 2 2 Repair protein Rad1/Rec1/Rad17 Hus1 PF04005.12 EMD62947.1 - 0.00015 21.0 0.0 0.00036 19.7 0.0 1.7 1 1 1 2 2 2 1 Hus1-like protein Rab5ip PF07019.12 EMD62948.1 - 1e-28 99.7 7.7 1.2e-28 99.5 7.7 1.1 1 0 0 1 1 1 1 Rab5-interacting protein (Rab5ip) RL11D PF11088.8 EMD62948.1 - 0.046 14.0 0.0 0.071 13.4 0.0 1.3 1 0 0 1 1 1 0 Glycoprotein encoding membrane proteins RL5A and RL6 Sigma70_r4_2 PF08281.12 EMD62950.1 - 0.001 18.7 0.1 0.0016 18.0 0.1 1.3 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_32 PF13565.6 EMD62950.1 - 0.026 15.1 0.3 0.058 14.0 0.2 1.7 2 1 0 2 2 2 0 Homeodomain-like domain HTH_23 PF13384.6 EMD62950.1 - 0.082 12.7 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 Homeodomain-like domain Sigma70_r4 PF04545.16 EMD62950.1 - 0.097 12.2 0.0 0.2 11.2 0.0 1.5 1 0 0 1 1 1 0 Sigma-70, region 4 Vezatin PF12632.7 EMD62951.1 - 1.1e-64 218.5 0.0 2.3e-64 217.5 0.0 1.5 2 0 0 2 2 2 1 Mysoin-binding motif of peroxisomes TGT_C2 PF14810.6 EMD62951.1 - 0.14 12.3 0.1 0.3 11.2 0.1 1.5 1 0 0 1 1 1 0 Patch-forming domain C2 of tRNA-guanine transglycosylase DUF2517 PF10725.9 EMD62951.1 - 1.3 8.8 3.2 2.7 7.8 3.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2517) ADH_N PF08240.12 EMD62953.1 - 1e-24 86.5 1.8 1.8e-24 85.7 1.8 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EMD62953.1 - 2.6e-22 79.2 0.0 3.9e-22 78.6 0.0 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EMD62953.1 - 8.2e-05 23.7 0.0 0.00016 22.7 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 EMD62953.1 - 0.0027 17.1 0.1 0.0046 16.3 0.1 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 EMD62953.1 - 0.058 12.7 0.0 0.1 11.9 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain CFEM PF05730.11 EMD62954.1 - 6.5e-15 55.0 13.8 1.1e-14 54.3 13.8 1.4 1 0 0 1 1 1 1 CFEM domain PPR_2 PF13041.6 EMD62955.1 - 2.3e-11 43.7 0.7 0.03 14.5 0.1 5.1 4 1 1 5 5 5 4 PPR repeat family PPR_3 PF13812.6 EMD62955.1 - 1.8e-05 24.7 0.3 0.22 11.6 0.0 4.1 3 1 1 4 4 4 2 Pentatricopeptide repeat domain PPR PF01535.20 EMD62955.1 - 0.019 15.2 0.1 23 5.5 0.0 4.8 5 0 0 5 5 5 0 PPR repeat TRIF-NTD PF17798.1 EMD62955.1 - 0.077 13.1 0.1 0.17 12.0 0.1 1.5 1 0 0 1 1 1 0 TRIF N-terminal domain MFS_1 PF07690.16 EMD62956.1 - 2.7e-49 168.0 37.3 2.2e-44 151.8 20.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EMD62956.1 - 0.0009 18.2 23.9 0.016 14.1 23.9 2.9 1 1 0 1 1 1 1 Sugar (and other) transporter OATP PF03137.20 EMD62956.1 - 4 5.6 7.1 24 3.1 5.1 2.8 1 1 1 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family DUF5455 PF17537.2 EMD62956.1 - 5.7 7.4 7.4 6.5 7.2 0.1 3.5 4 1 0 4 4 4 0 Family of unknown function (DUF5455) F-box-like_2 PF13013.6 EMD62957.1 - 0.012 15.5 0.0 0.027 14.4 0.0 1.6 1 0 0 1 1 1 0 F-box-like domain DHDPS PF00701.22 EMD62961.1 - 2.5e-38 131.4 0.0 3.5e-38 131.0 0.0 1.1 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family Toxin_ToxA PF11584.8 EMD62961.1 - 0.1 12.6 0.0 0.21 11.6 0.0 1.5 1 0 0 1 1 1 0 Proteinaceous host-selective toxin ToxA F-box-like PF12937.7 EMD62964.1 - 2.7e-06 27.2 0.4 1.5e-05 24.8 0.1 2.4 2 0 0 2 2 2 1 F-box-like RNA_pol_3_Rpc31 PF11705.8 EMD62964.1 - 0.49 10.6 14.1 0.82 9.9 14.1 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 NOA36 PF06524.12 EMD62964.1 - 0.6 9.4 7.0 0.93 8.8 7.0 1.2 1 0 0 1 1 1 0 NOA36 protein Astro_capsid_p PF12226.8 EMD62964.1 - 1.5 7.9 6.1 2.4 7.2 6.1 1.3 1 0 0 1 1 1 0 Turkey astrovirus capsid protein ANAPC15 PF15243.6 EMD62964.1 - 5.3 7.5 16.2 11 6.5 16.2 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 15 LMBR1 PF04791.16 EMD62965.1 - 1e-20 74.2 14.5 3.9e-20 72.2 0.3 2.5 2 1 1 3 3 3 2 LMBR1-like membrane protein CPSF_A PF03178.15 EMD62966.1 - 8.9e-96 321.0 0.0 1.7e-95 320.1 0.0 1.5 1 0 0 1 1 1 1 CPSF A subunit region MMS1_N PF10433.9 EMD62966.1 - 4.7e-24 84.9 0.0 7e-24 84.3 0.0 1.2 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term DnaJ_C PF01556.18 EMD62967.1 - 3.9e-40 137.4 0.1 5.2e-40 136.9 0.1 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EMD62967.1 - 3.5e-25 87.9 0.7 5.9e-25 87.2 0.7 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 EMD62967.1 - 1.8e-16 60.2 18.2 3.5e-16 59.3 18.2 1.5 1 0 0 1 1 1 1 DnaJ central domain DUF1356 PF07092.12 EMD62967.1 - 0.13 11.5 2.5 1.9 7.7 0.4 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1356) Anti-TRAP PF15777.5 EMD62967.1 - 0.17 11.8 16.8 0.52 10.3 1.9 2.5 1 1 1 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein zinc_ribbon_9 PF14369.6 EMD62967.1 - 0.31 11.3 2.9 18 5.7 0.0 3.3 3 0 0 3 3 3 0 zinc-ribbon HypA PF01155.19 EMD62967.1 - 0.65 10.0 9.9 0.47 10.5 2.1 2.4 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc-ribbons_6 PF07191.12 EMD62967.1 - 0.77 9.8 8.3 4.4 7.4 2.0 2.4 1 1 1 2 2 2 0 zinc-ribbons DUF2614 PF11023.8 EMD62967.1 - 1.1 9.4 6.7 4.2 7.5 0.9 2.2 1 1 1 2 2 2 0 Zinc-ribbon containing domain Zn_Tnp_IS1595 PF12760.7 EMD62967.1 - 6.7 6.8 7.8 8 6.5 1.4 2.5 2 0 0 2 2 2 0 Transposase zinc-ribbon domain URO-D PF01208.17 EMD62968.1 - 2.9e-128 427.9 0.0 3.2e-128 427.7 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen decarboxylase (URO-D) MutS_V PF00488.21 EMD62969.1 - 1.7e-72 243.5 0.0 2.7e-72 242.8 0.0 1.4 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 EMD62969.1 - 2.7e-40 138.7 6.5 6.6e-40 137.4 6.5 1.7 1 0 0 1 1 1 1 MutS domain III MutS_I PF01624.20 EMD62969.1 - 3.4e-19 69.1 0.0 8.3e-19 67.9 0.0 1.7 1 0 0 1 1 1 1 MutS domain I MutS_II PF05188.17 EMD62969.1 - 3e-08 34.0 0.0 1.7e-07 31.6 0.0 2.3 2 0 0 2 2 2 1 MutS domain II CCDC92 PF14916.6 EMD62969.1 - 0.031 14.0 0.7 0.077 12.8 0.7 1.6 1 0 0 1 1 1 0 Coiled-coil domain of unknown function AAA_27 PF13514.6 EMD62969.1 - 0.066 12.8 0.0 0.22 11.1 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.6 EMD62969.1 - 0.14 12.2 0.0 0.58 10.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain NUC130_3NT PF08158.12 EMD62969.1 - 1.3 9.4 6.4 11 6.4 0.1 4.0 4 0 0 4 4 4 0 NUC130/3NT domain AAA_23 PF13476.6 EMD62969.1 - 1.6 9.2 0.0 1.6 9.2 0.0 2.4 2 1 0 2 2 2 0 AAA domain SnoaL_2 PF12680.7 EMD62971.1 - 5.4e-06 27.0 0.0 2.6e-05 24.8 0.0 2.0 2 0 0 2 2 2 1 SnoaL-like domain SnoaL PF07366.12 EMD62971.1 - 0.00065 19.5 0.0 0.0011 18.8 0.0 1.3 1 0 0 1 1 1 1 SnoaL-like polyketide cyclase KilA-N PF04383.13 EMD62972.1 - 0.00041 20.2 0.0 0.0039 17.0 0.0 2.2 1 1 0 1 1 1 1 KilA-N domain Zn_clus PF00172.18 EMD62972.1 - 0.0068 16.5 10.1 0.014 15.5 10.1 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-C2H2_4 PF13894.6 EMD62972.1 - 0.36 11.8 6.8 16 6.6 0.3 4.0 3 0 0 3 3 3 0 C2H2-type zinc finger CENP-H PF05837.12 EMD62973.1 - 0.023 15.1 1.3 0.076 13.4 1.3 1.9 1 0 0 1 1 1 0 Centromere protein H (CENP-H) CorA PF01544.18 EMD62973.1 - 0.065 12.5 0.5 0.15 11.4 0.2 1.7 1 1 0 2 2 2 0 CorA-like Mg2+ transporter protein DUF1794 PF08768.11 EMD62973.1 - 0.074 13.0 0.3 0.39 10.7 0.0 2.2 3 0 0 3 3 3 0 Domain of unknown function (DUF1794) Get5_C PF18514.1 EMD62973.1 - 0.17 11.6 0.4 1.9 8.2 0.0 2.5 2 0 0 2 2 2 0 Get5 C-terminal domain PRKG1_interact PF15898.5 EMD62973.1 - 0.89 10.5 4.9 0.95 10.4 2.5 2.3 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain MRP-S26 PF14943.6 EMD62973.1 - 9.3 6.1 8.1 6.5 6.6 3.1 2.3 1 1 1 2 2 2 0 Mitochondrial ribosome subunit S26 DUF3659 PF12396.8 EMD62974.1 - 0 992.2 195.9 2.4e-24 85.0 3.2 16.2 17 0 0 17 17 17 15 Protein of unknown function (DUF3659) DUF2167 PF09935.9 EMD62974.1 - 0.01 15.0 0.6 0.034 13.3 0.6 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2167) DUF2171 PF09939.9 EMD62974.1 - 1.1 9.5 25.2 1.8 8.9 0.1 7.3 7 0 0 7 7 7 0 Uncharacterized protein conserved in bacteria (DUF2171) RPW8 PF05659.11 EMD62974.1 - 1.8 8.3 3.9 0.76 9.5 0.2 2.2 3 0 0 3 3 3 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 Phage_fiber_C PF06820.12 EMD62974.1 - 2 8.8 14.7 11 6.5 0.0 7.1 9 0 0 9 9 9 0 Putative prophage tail fibre C-terminus AAA PF00004.29 EMD62976.1 - 1.2e-52 177.9 0.0 2.2e-44 151.1 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EMD62976.1 - 8.5e-05 23.0 1.3 0.023 15.1 0.0 3.9 3 1 0 4 4 3 1 AAA ATPase domain RuvB_N PF05496.12 EMD62976.1 - 0.00013 21.7 0.0 0.00046 20.0 0.0 1.9 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain Parvo_NS1 PF01057.17 EMD62976.1 - 0.00059 19.0 0.0 0.00099 18.3 0.0 1.2 1 0 0 1 1 1 1 Parvovirus non-structural protein NS1 AAA_22 PF13401.6 EMD62976.1 - 0.00088 19.6 0.1 0.044 14.0 0.0 3.1 2 1 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 EMD62976.1 - 0.0027 18.1 0.0 0.016 15.6 0.0 2.2 2 0 0 2 2 2 1 RNA helicase AAA_2 PF07724.14 EMD62976.1 - 0.0038 17.4 0.0 0.0094 16.1 0.0 1.7 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) TIP49 PF06068.13 EMD62976.1 - 0.0062 15.8 0.0 0.012 14.9 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain IstB_IS21 PF01695.17 EMD62976.1 - 0.0087 15.8 0.0 0.018 14.8 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_25 PF13481.6 EMD62976.1 - 0.015 14.9 0.0 0.084 12.4 0.0 2.3 1 1 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 EMD62976.1 - 0.026 13.9 0.1 0.054 12.9 0.1 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI ATPase PF06745.13 EMD62976.1 - 0.026 13.9 0.2 0.084 12.2 0.0 1.9 2 0 0 2 2 2 0 KaiC TsaE PF02367.17 EMD62976.1 - 0.031 14.3 0.1 0.17 11.9 0.0 2.0 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_18 PF13238.6 EMD62976.1 - 0.034 14.7 0.0 0.12 12.9 0.0 2.0 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 EMD62976.1 - 0.037 14.0 0.0 0.13 12.3 0.0 2.0 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 EMD62976.1 - 0.042 13.4 0.0 0.082 12.4 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region Vps4_C PF09336.10 EMD62976.1 - 0.047 13.7 0.2 0.51 10.4 0.0 2.7 3 0 0 3 3 2 0 Vps4 C terminal oligomerisation domain AAA_33 PF13671.6 EMD62976.1 - 0.049 13.8 0.0 0.43 10.7 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_lid_3 PF17862.1 EMD62976.1 - 0.061 13.1 7.3 0.079 12.8 0.0 2.9 3 0 0 3 3 2 0 AAA+ lid domain NB-ARC PF00931.22 EMD62976.1 - 0.074 12.2 0.0 3 7.0 0.0 2.9 3 0 0 3 3 3 0 NB-ARC domain PhoH PF02562.16 EMD62976.1 - 0.084 12.3 0.0 0.2 11.1 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein AAA_28 PF13521.6 EMD62976.1 - 0.12 12.6 0.0 0.31 11.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain PPV_E1_C PF00519.17 EMD62976.1 - 0.21 10.4 0.4 0.49 9.2 0.0 1.6 2 0 0 2 2 2 0 Papillomavirus helicase Abhydro_lipase PF04083.16 EMD62977.1 - 2.4e-18 65.5 0.0 8.3e-18 63.7 0.0 2.0 2 0 0 2 2 2 1 Partial alpha/beta-hydrolase lipase region Abhydrolase_1 PF00561.20 EMD62977.1 - 2.8e-09 37.0 0.0 6.5e-08 32.5 0.0 2.3 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EMD62977.1 - 0.00048 19.5 0.0 0.00097 18.5 0.0 1.5 1 0 0 1 1 1 1 Serine aminopeptidase, S33 DUF900 PF05990.12 EMD62977.1 - 0.054 13.0 0.0 0.23 11.0 0.0 1.8 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF900) HTH_48 PF17906.1 EMD62977.1 - 0.071 13.2 0.1 0.2 11.8 0.1 1.8 1 0 0 1 1 1 0 HTH domain in Mos1 transposase Tubulin PF00091.25 EMD62978.1 - 3.2e-65 220.0 0.0 4.3e-65 219.6 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EMD62978.1 - 9.8e-44 148.5 0.0 1.5e-43 147.9 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 EMD62978.1 - 0.0024 17.6 0.0 0.0048 16.6 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain MS_channel PF00924.18 EMD62979.1 - 4.7e-22 78.5 1.3 7.9e-22 77.8 1.3 1.3 1 0 0 1 1 1 1 Mechanosensitive ion channel EF-hand_5 PF13202.6 EMD62979.1 - 0.0001 21.6 0.0 0.00025 20.4 0.0 1.7 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.32 EMD62979.1 - 0.0013 18.1 0.1 0.003 17.0 0.1 1.7 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 EMD62979.1 - 0.0026 17.5 0.0 0.0074 16.1 0.0 1.8 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.6 EMD62979.1 - 0.0089 16.5 0.1 0.023 15.1 0.1 1.7 1 0 0 1 1 1 1 EF-hand domain pair TraG_N PF07916.11 EMD62979.1 - 1.6 7.5 4.8 0.79 8.5 0.0 2.1 2 0 0 2 2 2 0 TraG-like protein, N-terminal region Questin_oxidase PF14027.6 EMD62980.1 - 4.1e-93 312.6 0.1 4.9e-93 312.4 0.1 1.1 1 0 0 1 1 1 1 Questin oxidase-like FAM60A PF15396.6 EMD62980.1 - 0.19 11.7 0.5 0.31 11.0 0.5 1.2 1 0 0 1 1 1 0 Protein Family FAM60A AA_permease_2 PF13520.6 EMD62981.1 - 2.2e-46 158.6 52.9 2.7e-46 158.3 52.9 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EMD62981.1 - 1.1e-21 77.0 34.1 1.1e-21 77.0 34.1 1.7 2 0 0 2 2 2 1 Amino acid permease Orai-1 PF07856.12 EMD62981.1 - 0.13 12.0 5.7 0.32 10.6 4.9 2.1 1 1 0 1 1 1 0 Mediator of CRAC channel activity AA_permease PF00324.21 EMD62982.1 - 9.2e-125 416.9 46.8 1.1e-124 416.6 46.8 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EMD62982.1 - 7.8e-29 100.7 50.9 1e-28 100.3 50.9 1.0 1 0 0 1 1 1 1 Amino acid permease Glyco_hydro_88 PF07470.13 EMD62983.1 - 3.8e-12 45.9 0.0 6.7e-12 45.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyl Hydrolase Family 88 CDP-OH_P_transf PF01066.21 EMD62984.1 - 3e-15 56.7 0.1 3e-15 56.7 0.1 2.9 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase PX PF00787.24 EMD62985.1 - 3.1e-19 69.0 1.5 1.3e-18 67.0 0.6 2.5 3 1 0 3 3 3 1 PX domain Vps5 PF09325.10 EMD62985.1 - 5.4e-10 39.2 6.0 1.7e-05 24.5 1.0 2.3 2 0 0 2 2 2 2 Vps5 C terminal like BAR_3 PF16746.5 EMD62985.1 - 0.0041 16.9 3.9 0.34 10.6 0.1 2.3 2 0 0 2 2 2 2 BAR domain of APPL family BAR PF03114.18 EMD62985.1 - 0.0044 16.7 6.0 0.091 12.4 6.0 2.5 1 1 0 1 1 1 1 BAR domain Sec34 PF04136.15 EMD62985.1 - 0.024 14.5 1.0 0.024 14.5 1.0 1.9 2 0 0 2 2 2 0 Sec34-like family EcsC PF12787.7 EMD62985.1 - 0.048 13.3 0.1 0.083 12.5 0.1 1.5 1 0 0 1 1 1 0 EcsC protein family PIN_8 PF18476.1 EMD62985.1 - 0.91 9.3 8.2 0.049 13.5 0.8 2.2 3 0 0 3 3 3 0 PIN like domain ADK PF00406.22 EMD62986.1 - 6.6e-38 130.2 0.0 5e-20 72.1 0.1 2.1 1 1 1 2 2 2 2 Adenylate kinase AAA_17 PF13207.6 EMD62986.1 - 3.1e-15 56.8 0.0 2.1e-10 41.1 0.0 2.2 1 1 1 2 2 2 2 AAA domain ADK_lid PF05191.14 EMD62986.1 - 9.5e-15 54.3 0.0 1.7e-14 53.5 0.0 1.4 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_18 PF13238.6 EMD62986.1 - 7.6e-05 23.3 0.0 0.00067 20.2 0.0 2.1 1 1 0 1 1 1 1 AAA domain MeaB PF03308.16 EMD62986.1 - 0.014 14.4 0.1 0.022 13.7 0.1 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_33 PF13671.6 EMD62986.1 - 0.03 14.5 0.0 0.12 12.5 0.0 1.9 2 0 0 2 2 2 0 AAA domain LETM1 PF07766.13 EMD62987.1 - 1.9e-104 348.7 0.9 2.7e-104 348.3 0.0 1.7 2 0 0 2 2 2 1 LETM1-like protein SAP PF02037.27 EMD62987.1 - 0.00013 21.6 0.0 0.028 14.2 0.0 3.2 3 0 0 3 3 3 1 SAP domain Peptidase_M76 PF09768.9 EMD62987.1 - 0.064 13.0 0.0 0.36 10.6 0.0 2.1 2 0 0 2 2 2 0 Peptidase M76 family DUF5082 PF16888.5 EMD62989.1 - 0.0074 16.6 0.1 0.023 14.9 0.1 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF5082) SPT2 PF08243.11 EMD62990.1 - 3.7e-05 24.2 19.4 0.00012 22.6 19.6 1.8 1 1 0 1 1 1 1 SPT2 chromatin protein Ribosomal_60s PF00428.19 EMD62991.1 - 3.6e-26 91.6 11.0 4.1e-26 91.4 11.0 1.0 1 0 0 1 1 1 1 60s Acidic ribosomal protein EF-hand_14 PF17959.1 EMD62991.1 - 0.0085 16.4 0.0 0.012 15.9 0.0 1.2 1 0 0 1 1 1 1 EF-hand domain Ribosomal_S19 PF00203.21 EMD62992.1 - 3e-32 110.3 0.2 3.9e-32 110.0 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein S19 Prenyltransf PF01255.19 EMD62993.1 - 6.1e-05 22.7 0.0 0.00046 19.8 0.0 2.0 2 0 0 2 2 2 1 Putative undecaprenyl diphosphate synthase DUF5099 PF17025.5 EMD62993.1 - 0.0045 17.4 0.0 0.008 16.6 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF5099) Neogenin_C PF06583.12 EMD62993.1 - 0.028 14.2 0.1 2.5 7.8 0.1 2.2 2 0 0 2 2 2 0 Neogenin C-terminus Sec10 PF07393.11 EMD62994.1 - 5.8e-198 659.7 0.0 6.8e-198 659.5 0.0 1.1 1 0 0 1 1 1 1 Exocyst complex component Sec10 MarR_2 PF12802.7 EMD62994.1 - 0.056 13.3 0.1 0.33 10.9 0.0 2.4 2 0 0 2 2 2 0 MarR family RAP1 PF07218.11 EMD62996.1 - 1.5 7.0 2.4 1.8 6.8 2.4 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) PTR2 PF00854.21 EMD62997.1 - 1.7e-90 303.7 3.7 4.6e-90 302.3 3.7 1.6 1 1 0 1 1 1 1 POT family TraQ PF09679.10 EMD62997.1 - 0.36 10.8 0.1 0.36 10.8 0.1 2.4 3 0 0 3 3 3 0 Type-F conjugative transfer system pilin chaperone (TraQ) NDUF_B12 PF08122.12 EMD62997.1 - 0.86 9.7 5.2 0.82 9.8 0.1 2.8 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase B12 subunit family Cation_efflux PF01545.21 EMD62998.1 - 5.7e-51 173.1 17.0 1.7e-50 171.6 17.0 1.7 1 1 0 1 1 1 1 Cation efflux family KIAA1328 PF15369.6 EMD62998.1 - 0.12 12.2 7.8 0.17 11.7 7.8 1.2 1 0 0 1 1 1 0 Uncharacterised protein KIAA1328 Sporozoite_P67 PF05642.11 EMD62998.1 - 1.1 7.2 6.2 1.9 6.5 6.2 1.4 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Zip PF02535.22 EMD62998.1 - 2.5 7.2 23.7 0.31 10.2 6.2 2.5 1 1 1 2 2 2 0 ZIP Zinc transporter Ofd1_CTDD PF10637.9 EMD62999.1 - 8.8e-93 310.3 0.0 3.4e-88 295.3 0.0 2.2 2 0 0 2 2 2 2 Oxoglutarate and iron-dependent oxygenase degradation C-term 2OG-FeII_Oxy_4 PF13661.6 EMD62999.1 - 2.4e-24 85.8 0.0 8.3e-24 84.1 0.0 1.9 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.6 EMD62999.1 - 2.1e-12 47.7 0.0 4.7e-12 46.6 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily EntA_Immun PF08951.10 EMD62999.1 - 0.018 15.4 0.1 0.047 14.0 0.1 1.8 1 0 0 1 1 1 0 Enterocin A Immunity Dynamitin PF04912.14 EMD63000.1 - 1.9e-91 307.3 11.4 2.1e-91 307.1 11.4 1.0 1 0 0 1 1 1 1 Dynamitin Lectin_N PF03954.14 EMD63000.1 - 0.03 14.1 0.6 0.03 14.1 0.6 2.2 3 0 0 3 3 3 0 Hepatic lectin, N-terminal domain SlyX PF04102.12 EMD63000.1 - 0.049 14.3 9.0 2.9 8.6 1.3 4.8 3 1 0 3 3 3 0 SlyX DUF16 PF01519.16 EMD63000.1 - 0.84 10.2 6.5 5.2 7.6 1.2 3.6 4 0 0 4 4 4 0 Protein of unknown function DUF16 Baculo_PEP_C PF04513.12 EMD63000.1 - 2.3 8.3 6.1 3.2 7.8 0.3 2.8 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus P34-Arc PF04045.14 EMD63001.1 - 2.2e-107 358.2 0.3 2.7e-107 358.0 0.3 1.0 1 0 0 1 1 1 1 Arp2/3 complex, 34 kD subunit p34-Arc ARPC4 PF05856.12 EMD63001.1 - 0.0038 16.8 0.0 0.019 14.6 0.0 2.0 2 0 0 2 2 2 1 ARP2/3 complex 20 kDa subunit (ARPC4) WD40 PF00400.32 EMD63002.1 - 8.6e-51 168.8 29.0 1.4e-05 25.8 0.2 11.9 11 1 0 11 11 11 10 WD domain, G-beta repeat Utp12 PF04003.12 EMD63002.1 - 7.4e-21 74.5 0.1 1.4e-20 73.6 0.1 1.4 1 0 0 1 1 1 1 Dip2/Utp12 Family ANAPC4_WD40 PF12894.7 EMD63002.1 - 2.1e-19 69.6 7.3 0.0087 16.3 0.0 9.6 6 4 4 10 10 10 6 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EMD63002.1 - 6.3e-07 28.4 4.9 0.1 11.2 0.0 6.4 5 2 1 7 7 7 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 EMD63002.1 - 6.4e-07 28.6 3.9 0.57 9.1 0.0 6.3 4 2 3 7 7 7 3 WD40 region of Ge1, enhancer of mRNA-decapping protein BBS2_Mid PF14783.6 EMD63002.1 - 4.2e-06 26.8 4.5 19 5.4 0.0 8.0 6 2 3 9 9 9 0 Ciliary BBSome complex subunit 2, middle region eIF2A PF08662.11 EMD63002.1 - 0.00014 21.8 0.3 0.067 13.1 0.0 4.4 3 1 1 4 4 4 1 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 EMD63002.1 - 0.0037 16.6 0.0 7.8 5.7 0.0 3.6 3 1 0 3 3 3 1 WD40-like domain Nucleoporin_N PF08801.11 EMD63002.1 - 0.024 13.4 1.0 4.2 6.0 0.0 4.1 3 2 1 4 4 4 0 Nup133 N terminal like Nbas_N PF15492.6 EMD63002.1 - 0.042 13.2 0.3 11 5.3 0.0 3.3 1 1 2 3 3 3 0 Neuroblastoma-amplified sequence, N terminal Rtf2 PF04641.12 EMD63002.1 - 0.088 12.2 0.7 0.2 11.0 0.7 1.6 1 0 0 1 1 1 0 Rtf2 RING-finger COesterase PF00135.28 EMD63003.1 - 8.7e-51 173.3 0.0 1.2e-50 172.9 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EMD63003.1 - 7.5e-07 29.2 0.1 0.00023 21.1 0.0 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EMD63003.1 - 0.21 11.1 0.9 0.46 9.9 0.0 1.9 2 0 0 2 2 2 0 Prolyl oligopeptidase family DRMBL PF07522.14 EMD63004.1 - 3.3e-34 117.4 0.0 6.1e-34 116.5 0.0 1.5 1 0 0 1 1 1 1 DNA repair metallo-beta-lactamase Lactamase_B_2 PF12706.7 EMD63004.1 - 0.00014 21.4 0.0 0.00029 20.4 0.0 1.5 1 0 0 1 1 1 1 Beta-lactamase superfamily domain UBZ_FAAP20 PF15750.5 EMD63004.1 - 0.13 12.3 0.1 0.29 11.1 0.1 1.6 1 0 0 1 1 1 0 Ubiquitin-binding zinc-finger Flavin_Reduct PF01613.18 EMD63005.1 - 0.02 15.0 2.6 0.026 14.6 2.6 1.2 1 0 0 1 1 1 0 Flavin reductase like domain CYSTM PF12734.7 EMD63007.1 - 6.9e-05 23.1 38.5 6.9e-05 23.1 38.5 3.7 1 1 1 2 2 2 1 Cysteine-rich TM module stress tolerance SH3_1 PF00018.28 EMD63008.1 - 2.1e-36 123.3 6.9 1.5e-13 50.2 0.3 4.4 4 0 0 4 4 4 3 SH3 domain SHD1 PF03983.12 EMD63008.1 - 1.9e-35 120.5 0.1 3.2e-35 119.8 0.1 1.4 1 0 0 1 1 1 1 SLA1 homology domain 1, SHD1 SH3_9 PF14604.6 EMD63008.1 - 1.5e-31 108.0 7.3 2.5e-11 43.3 0.1 3.9 4 0 0 4 4 4 3 Variant SH3 domain SH3_2 PF07653.17 EMD63008.1 - 6.9e-26 89.7 0.0 9.9e-10 38.0 0.0 4.3 4 0 0 4 4 4 3 Variant SH3 domain DUF1720 PF08226.11 EMD63008.1 - 6.5e-06 26.5 33.6 6.5e-06 26.5 33.6 7.3 2 1 3 5 5 5 2 Domain of unknown function (DUF1720) SH3_3 PF08239.11 EMD63008.1 - 0.0058 16.9 4.9 1.4 9.3 0.6 2.9 3 0 0 3 3 3 2 Bacterial SH3 domain SH3_10 PF17902.1 EMD63008.1 - 0.012 15.7 0.1 0.61 10.2 0.0 3.2 3 0 0 3 3 3 0 SH3 domain SAM_4 PF18017.1 EMD63008.1 - 0.039 13.9 0.0 0.096 12.7 0.0 1.6 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) MFS_1 PF07690.16 EMD63009.1 - 1e-28 100.3 32.2 1.6e-28 99.7 32.2 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily GlpM PF06942.12 EMD63009.1 - 0.017 15.6 1.1 0.077 13.4 1.1 2.1 1 0 0 1 1 1 0 GlpM protein CBFB_NFYA PF02045.15 EMD63010.1 - 2.1e-28 98.7 3.3 6.5e-28 97.1 3.3 1.9 1 0 0 1 1 1 1 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B DUF2106 PF09879.9 EMD63010.1 - 0.22 11.1 2.5 0.38 10.3 2.5 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2106) TFIIA PF03153.13 EMD63010.1 - 8 6.3 48.3 31 4.4 48.3 1.7 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RRM_1 PF00076.22 EMD63011.1 - 2e-14 53.1 0.1 1.5e-09 37.6 0.0 3.5 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FYDLN_acid PF09538.10 EMD63011.1 - 0.59 10.8 32.3 1.4 9.6 9.7 2.9 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) BSP_II PF05432.11 EMD63011.1 - 0.84 9.3 38.9 1.5 8.4 38.9 1.4 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Sds3 PF08598.11 EMD63012.1 - 7.8e-15 55.5 4.9 7.8e-15 55.5 4.9 2.3 2 2 0 2 2 2 1 Sds3-like DUF1487 PF07368.11 EMD63012.1 - 0.048 13.1 0.4 0.28 10.6 0.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1487) Peptidase_C24 PF03510.14 EMD63013.1 - 2.3 8.8 6.3 12 6.5 2.9 2.7 2 1 1 3 3 3 0 2C endopeptidase (C24) cysteine protease family Pkinase PF00069.25 EMD63015.1 - 1.8e-51 175.0 0.0 2.7e-51 174.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD63015.1 - 2.4e-32 112.2 0.0 3.5e-32 111.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EMD63015.1 - 0.00022 20.1 1.2 0.0006 18.7 0.0 2.3 4 0 0 4 4 4 1 Fungal protein kinase Kinase-like PF14531.6 EMD63015.1 - 0.0037 16.6 0.0 0.0075 15.6 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EMD63015.1 - 0.007 15.3 0.0 0.2 10.5 0.0 2.1 2 0 0 2 2 2 1 Haspin like kinase domain FTA2 PF13095.6 EMD63015.1 - 0.0081 15.8 1.8 0.44 10.1 0.0 3.0 3 1 1 4 4 4 1 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 EMD63015.1 - 0.019 14.9 0.1 0.13 12.1 0.0 2.3 2 1 1 3 3 3 0 Phosphotransferase enzyme family MFS_1_like PF12832.7 EMD63016.1 - 0.15 10.8 1.1 0.18 10.6 1.1 1.1 1 0 0 1 1 1 0 MFS_1 like family zf-RING_2 PF13639.6 EMD63017.1 - 1.1e-11 44.8 6.3 1.8e-11 44.2 6.3 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EMD63017.1 - 5.7e-09 35.7 5.8 8.9e-09 35.1 5.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EMD63017.1 - 2.7e-07 30.2 1.1 4.5e-07 29.5 1.1 1.4 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4 PF00097.25 EMD63017.1 - 4.5e-07 29.6 3.7 7.4e-07 28.9 3.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EMD63017.1 - 1.8e-06 27.8 3.4 2.9e-06 27.1 3.4 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.7 EMD63017.1 - 3.7e-06 27.1 9.7 1.7e-05 25.0 9.7 2.0 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 EMD63017.1 - 0.00046 20.1 0.7 0.00046 20.1 0.7 2.2 2 0 0 2 2 2 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 EMD63017.1 - 0.0013 18.8 2.6 0.0032 17.5 2.6 1.7 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.6 EMD63017.1 - 0.0027 17.5 2.8 0.0046 16.8 2.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EMD63017.1 - 0.021 15.0 4.7 0.042 14.0 4.7 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Zn_ribbon_17 PF17120.5 EMD63017.1 - 0.033 13.8 4.3 0.07 12.8 4.3 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_4 PF14570.6 EMD63017.1 - 0.038 13.8 6.1 0.064 13.1 6.1 1.3 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain OAD_gamma PF04277.13 EMD63017.1 - 0.12 13.0 3.0 0.34 11.5 0.0 2.7 2 1 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain PHD PF00628.29 EMD63017.1 - 0.15 12.0 5.6 0.28 11.1 5.6 1.5 1 0 0 1 1 1 0 PHD-finger Prok-RING_4 PF14447.6 EMD63017.1 - 0.2 11.5 5.1 0.39 10.6 5.1 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 RINGv PF12906.7 EMD63017.1 - 0.61 10.3 4.0 1.5 9.0 4.0 1.7 1 1 0 1 1 1 0 RING-variant domain FAM176 PF14851.6 EMD63017.1 - 1.1 8.9 3.3 4.2 7.0 0.0 2.8 2 1 1 3 3 3 0 FAM176 family zf-RING_10 PF16685.5 EMD63017.1 - 1.2 9.3 3.6 2.4 8.3 3.6 1.4 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-C3H2C3 PF17122.5 EMD63017.1 - 1.5 8.9 5.6 3.1 7.9 5.6 1.6 1 1 0 1 1 1 0 Zinc-finger PAT1 PF09770.9 EMD63017.1 - 2.7 6.1 7.4 4.5 5.4 7.4 1.3 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Pro_isomerase PF00160.21 EMD63018.1 - 5.5e-49 166.5 1.1 6.3e-49 166.3 1.1 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RRN3 PF05327.11 EMD63019.1 - 1.7e-173 578.2 0.0 1.7e-173 578.2 0.0 2.0 2 0 0 2 2 2 1 RNA polymerase I specific transcription initiation factor RRN3 RNA_pol_Rpc4 PF05132.14 EMD63019.1 - 0.61 10.5 2.0 1.6 9.2 2.0 1.7 1 0 0 1 1 1 0 RNA polymerase III RPC4 SDA1 PF05285.12 EMD63019.1 - 4.8 6.5 29.3 0.04 13.3 17.6 2.2 2 0 0 2 2 2 0 SDA1 SAS4 PF15460.6 EMD63020.1 - 2.2e-33 114.3 1.8 3.4e-33 113.7 1.8 1.3 1 0 0 1 1 1 1 Something about silencing, SAS, complex subunit 4 PX PF00787.24 EMD63021.1 - 5e-21 74.8 0.0 6.6e-21 74.4 0.0 1.2 1 0 0 1 1 1 1 PX domain FAD_binding_3 PF01494.19 EMD63024.1 - 2.3e-26 92.9 0.1 5e-24 85.2 0.1 2.1 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EMD63024.1 - 1.8e-06 27.4 0.0 0.00096 18.5 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EMD63024.1 - 0.0044 16.1 2.7 0.031 13.3 0.2 2.6 3 0 0 3 3 3 1 Lycopene cyclase protein SE PF08491.10 EMD63024.1 - 0.0053 15.8 0.0 0.0093 15.0 0.0 1.3 1 0 0 1 1 1 1 Squalene epoxidase DAO PF01266.24 EMD63024.1 - 0.021 14.4 0.0 3.1 7.3 0.0 2.3 2 0 0 2 2 2 0 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EMD63024.1 - 0.052 13.5 0.0 0.14 12.2 0.0 1.7 2 0 0 2 2 2 0 FAD-NAD(P)-binding Pyr_redox PF00070.27 EMD63024.1 - 0.072 13.7 0.1 4 8.1 0.0 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EMD63024.1 - 0.12 11.6 0.0 0.19 10.9 0.0 1.2 1 0 0 1 1 1 0 Thi4 family HI0933_like PF03486.14 EMD63024.1 - 0.17 10.5 0.0 2 7.1 0.0 2.0 2 0 0 2 2 2 0 HI0933-like protein ChaC PF04752.12 EMD63025.1 - 5.6e-49 166.6 0.0 8.5e-49 166.0 0.0 1.2 1 0 0 1 1 1 1 ChaC-like protein Zip PF02535.22 EMD63026.1 - 2.4e-50 171.6 7.2 7.1e-50 170.1 7.2 1.7 1 1 0 1 1 1 1 ZIP Zinc transporter VRR_NUC PF08774.11 EMD63028.1 - 2.2e-21 75.9 0.0 6.5e-21 74.4 0.0 1.8 1 0 0 1 1 1 1 VRR-NUC domain FANC_SAP PF18081.1 EMD63028.1 - 0.032 14.4 0.4 0.097 12.8 0.4 1.9 1 0 0 1 1 1 0 Fanconi anemia-associated nuclease SAP domain MIEAP PF16026.5 EMD63028.1 - 0.056 13.7 1.4 0.12 12.5 1.4 1.5 1 0 0 1 1 1 0 Mitochondria-eating protein FANCI_S1-cap PF14674.6 EMD63028.1 - 0.083 13.0 1.1 0.28 11.3 1.1 1.9 1 0 0 1 1 1 0 FANCI solenoid 1 cap NPAT_C PF15712.5 EMD63028.1 - 1 7.9 6.6 1.7 7.2 6.6 1.2 1 0 0 1 1 1 0 NPAT C terminus TLP1_add_C PF18313.1 EMD63029.1 - 2.6e-30 104.2 0.0 7.3e-30 102.7 0.0 1.8 1 0 0 1 1 1 1 Thiolase-like protein type 1 additional C-terminal domain UCH PF00443.29 EMD63030.1 - 2.6e-57 194.3 0.0 4.9e-57 193.4 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EMD63030.1 - 4.8e-27 95.4 0.2 6.3e-21 75.3 0.0 2.4 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase Nop25 PF09805.9 EMD63030.1 - 0.00099 19.6 5.5 0.00099 19.6 5.5 2.3 2 0 0 2 2 2 1 Nucleolar protein 12 (25kDa) Peptidase_C98 PF15499.6 EMD63030.1 - 0.0016 18.0 2.8 0.025 14.0 1.4 2.6 2 0 0 2 2 2 1 Ubiquitin-specific peptidase-like, SUMO isopeptidase MYCBPAP PF14646.6 EMD63030.1 - 0.0073 15.3 7.0 0.0073 15.3 7.0 2.0 3 0 0 3 3 3 1 MYCBP-associated protein family Trp_dioxygenase PF03301.13 EMD63030.1 - 0.45 9.8 4.3 0.46 9.8 2.5 1.8 2 0 0 2 2 2 0 Tryptophan 2,3-dioxygenase SpoIIIAH PF12685.7 EMD63030.1 - 3.7 7.3 9.8 9 6.1 9.8 1.6 1 0 0 1 1 1 0 SpoIIIAH-like protein Synaphin PF05835.12 EMD63030.1 - 6.5 7.0 19.4 0.039 14.2 10.3 1.9 2 0 0 2 2 2 0 Synaphin protein Amino_oxidase PF01593.24 EMD63031.1 - 8.2e-89 299.0 0.1 4.8e-74 250.3 0.0 2.1 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase SWIRM PF04433.17 EMD63031.1 - 1.7e-14 53.9 0.0 4.5e-14 52.5 0.0 1.7 1 0 0 1 1 1 1 SWIRM domain NAD_binding_8 PF13450.6 EMD63031.1 - 4.2e-08 33.3 0.1 1.1e-07 32.0 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EMD63031.1 - 0.0002 21.1 0.1 0.0012 18.5 0.0 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EMD63031.1 - 0.00021 20.6 0.2 0.0045 16.3 0.0 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EMD63031.1 - 0.0027 17.7 0.1 0.83 9.6 0.1 2.6 2 0 0 2 2 2 2 FAD-NAD(P)-binding HMG_box PF00505.19 EMD63031.1 - 0.0077 16.6 3.5 0.0095 16.3 0.7 2.4 1 1 1 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EMD63031.1 - 0.032 14.8 0.1 0.07 13.7 0.1 1.5 1 0 0 1 1 1 0 HMG-box domain K_oxygenase PF13434.6 EMD63031.1 - 0.063 12.4 0.1 11 5.0 0.0 2.3 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) SNase PF00565.17 EMD63032.1 - 3.6e-25 88.5 0.5 5.9e-25 87.8 0.5 1.3 1 0 0 1 1 1 1 Staphylococcal nuclease homologue CPSase_L_D2 PF02786.17 EMD63033.1 - 3e-107 356.9 0.0 4e-81 271.5 0.0 2.3 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_D3 PF02787.19 EMD63033.1 - 1.5e-41 141.6 0.0 3.5e-41 140.4 0.0 1.7 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain ATP-grasp PF02222.22 EMD63033.1 - 1.3e-18 67.1 0.0 3.1e-09 36.6 0.0 2.4 2 0 0 2 2 2 2 ATP-grasp domain Dala_Dala_lig_C PF07478.13 EMD63033.1 - 3.9e-17 62.5 0.2 1.9e-09 37.4 0.1 2.4 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus ATPgrasp_Ter PF15632.6 EMD63033.1 - 1.2e-10 41.2 0.0 0.00016 21.5 0.0 2.6 2 0 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon RimK PF08443.11 EMD63033.1 - 1.6e-05 24.6 0.0 0.0096 15.5 0.0 2.4 2 0 0 2 2 2 2 RimK-like ATP-grasp domain ATP-grasp_5 PF13549.6 EMD63033.1 - 2e-05 24.2 0.1 0.018 14.5 0.1 3.2 2 1 1 3 3 3 2 ATP-grasp domain GARS_A PF01071.19 EMD63033.1 - 0.00059 19.7 0.1 0.27 11.0 0.0 2.6 2 0 0 2 2 2 2 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain DUF202 PF02656.15 EMD63035.1 - 1.7e-17 63.6 0.2 1.7e-17 63.6 0.2 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF202) PhaG_MnhG_YufB PF03334.14 EMD63035.1 - 1.1 9.5 10.0 0.2 11.9 5.9 1.8 2 0 0 2 2 2 0 Na+/H+ antiporter subunit Glyco_transf_34 PF05637.12 EMD63037.1 - 6.7e-65 219.2 0.8 1e-64 218.6 0.8 1.2 1 0 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family Sugar_tr PF00083.24 EMD63039.1 - 1.1e-23 83.8 18.7 1.8e-14 53.5 5.7 2.1 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 EMD63039.1 - 3.4e-06 26.2 34.8 7.3e-05 21.8 10.7 3.1 1 1 1 3 3 3 2 Major Facilitator Superfamily PIR PF00399.19 EMD63040.1 - 2.7e-06 26.8 4.7 7.4e-06 25.4 4.7 1.8 1 0 0 1 1 1 1 Yeast PIR protein repeat CBF PF03914.17 EMD63041.1 - 7.7e-36 123.7 0.8 2.4e-35 122.1 0.0 2.2 2 1 0 2 2 2 1 CBF/Mak21 family Mt_ATP-synt_B PF05405.14 EMD63042.1 - 2.5e-49 167.0 9.3 3.1e-49 166.7 9.3 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) V_ATPase_I PF01496.19 EMD63042.1 - 0.35 8.7 6.0 0.43 8.4 6.0 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Epimerase PF01370.21 EMD63043.1 - 3.3e-19 69.3 0.0 4.5e-19 68.9 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 EMD63043.1 - 1.5e-11 43.9 0.0 2.4e-11 43.3 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain GDP_Man_Dehyd PF16363.5 EMD63043.1 - 1.7e-07 31.0 0.0 2.9e-07 30.2 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 EMD63043.1 - 3.9e-05 22.8 0.0 7.7e-05 21.8 0.0 1.5 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 EMD63043.1 - 0.047 12.8 0.0 0.1 11.7 0.0 1.6 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein Topoisom_I PF01028.20 EMD63044.1 - 1.6e-97 325.3 4.3 1.6e-97 325.3 4.3 2.3 3 1 1 4 4 4 1 Eukaryotic DNA topoisomerase I, catalytic core Topoisom_I_N PF02919.15 EMD63044.1 - 2.1e-97 324.8 4.4 2.1e-97 324.8 4.4 3.2 4 0 0 4 4 4 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Topo_C_assoc PF14370.6 EMD63044.1 - 3.4e-34 116.6 0.7 1.1e-33 114.9 0.7 2.0 1 0 0 1 1 1 1 C-terminal topoisomerase domain Csm1_N PF18504.1 EMD63044.1 - 0.0055 17.0 1.6 0.0055 17.0 1.6 4.0 4 1 1 5 5 5 1 Csm1 N-terminal domain ATP-synt PF00231.19 EMD63045.1 - 3e-78 263.4 3.0 3.7e-78 263.1 3.0 1.0 1 0 0 1 1 1 1 ATP synthase RNA_pol_A_bac PF01000.26 EMD63047.1 - 9e-25 87.2 0.0 1.5e-24 86.6 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 EMD63047.1 - 1e-20 72.9 0.0 2.4e-20 71.7 0.0 1.6 1 1 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Complex1_49kDa PF00346.19 EMD63048.1 - 1.6e-123 411.1 0.0 2.3e-123 410.6 0.0 1.2 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 49 Kd subunit NiFeSe_Hases PF00374.19 EMD63048.1 - 0.0076 15.2 0.0 0.011 14.7 0.0 1.3 1 0 0 1 1 1 1 Nickel-dependent hydrogenase TFIIS_M PF07500.14 EMD63049.1 - 3.1e-31 108.2 2.2 3.1e-31 108.2 2.2 2.3 2 1 1 3 3 3 1 Transcription factor S-II (TFIIS), central domain TFIIS_C PF01096.18 EMD63049.1 - 3.2e-18 65.3 8.8 5.1e-18 64.6 8.8 1.4 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) Med26 PF08711.11 EMD63049.1 - 2.5e-13 49.8 3.2 5.4e-13 48.7 0.9 2.6 3 0 0 3 3 3 1 TFIIS helical bundle-like domain WPP PF13943.6 EMD63049.1 - 0.07 13.5 2.4 1.1 9.7 0.2 2.5 1 1 1 2 2 2 0 WPP domain CcmH PF03918.14 EMD63049.1 - 0.3 10.4 2.9 0.64 9.3 2.9 1.6 1 0 0 1 1 1 0 Cytochrome C biogenesis protein NuA4 PF09340.10 EMD63050.1 - 3.7e-26 90.8 0.1 3.7e-26 90.8 0.1 1.7 2 0 0 2 2 2 1 Histone acetyltransferase subunit NuA4 MSA-2c PF12238.8 EMD63050.1 - 0.018 15.0 0.2 0.024 14.6 0.2 1.2 1 0 0 1 1 1 0 Merozoite surface antigen 2c zf-C2H2 PF00096.26 EMD63052.1 - 3.5e-10 39.8 11.4 1.5e-05 25.2 4.4 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMD63052.1 - 1.4e-08 34.8 13.2 5.1e-05 23.5 0.5 3.4 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMD63052.1 - 3.9e-07 30.3 10.6 0.00062 20.4 2.9 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-met PF12874.7 EMD63052.1 - 7e-06 26.3 1.2 1.9e-05 24.9 1.2 1.8 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 EMD63052.1 - 0.00014 21.8 2.1 0.00014 21.8 2.1 2.4 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EMD63052.1 - 0.00079 19.7 5.0 0.001 19.3 2.5 2.3 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 EMD63052.1 - 0.065 13.6 1.9 0.097 13.0 1.2 1.6 1 1 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf-C2HC_2 PF13913.6 EMD63052.1 - 0.18 11.7 5.0 3.9 7.5 0.4 2.4 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf-C2H2_11 PF16622.5 EMD63052.1 - 0.42 10.4 9.3 1.4 8.8 1.1 2.6 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-BED PF02892.15 EMD63052.1 - 2.5 8.2 5.4 0.83 9.7 0.9 2.1 2 0 0 2 2 2 0 BED zinc finger HATPase_c PF02518.26 EMD63054.1 - 3.8e-31 107.9 0.2 7.5e-31 106.9 0.2 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 EMD63054.1 - 3.4e-21 75.1 1.1 1.9e-20 72.7 0.0 2.9 3 0 0 3 3 3 1 His Kinase A (phospho-acceptor) domain Response_reg PF00072.24 EMD63054.1 - 8.4e-20 71.0 0.0 3.7e-19 69.0 0.0 2.2 1 0 0 1 1 1 1 Response regulator receiver domain PAS_3 PF08447.12 EMD63054.1 - 1.9e-15 56.9 0.9 6.3e-15 55.2 0.9 2.0 1 0 0 1 1 1 1 PAS fold PAS_4 PF08448.10 EMD63054.1 - 1.5e-14 54.2 0.8 2.7e-05 24.4 0.1 4.8 4 0 0 4 4 4 3 PAS fold PAS_9 PF13426.7 EMD63054.1 - 4e-14 52.7 0.0 2.8e-06 27.5 0.0 4.7 4 0 0 4 4 4 3 PAS domain PAS PF00989.25 EMD63054.1 - 1.1e-12 48.0 0.1 3.8e-05 23.7 0.0 3.8 3 0 0 3 3 3 3 PAS fold PAS_8 PF13188.7 EMD63054.1 - 0.0048 16.9 0.0 14 5.8 0.0 3.6 3 0 0 3 3 3 1 PAS domain HATPase_c_3 PF13589.6 EMD63054.1 - 0.0056 16.5 0.0 0.013 15.3 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF1835 PF08874.10 EMD63054.1 - 0.079 13.2 0.5 10 6.4 0.1 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1835) Yos1 PF08571.10 EMD63055.1 - 1.1e-33 115.3 0.3 1.2e-33 115.2 0.3 1.0 1 0 0 1 1 1 1 Yos1-like TFIIF_beta PF02270.15 EMD63057.1 - 3.1e-24 84.9 0.2 5.3e-24 84.1 0.2 1.4 1 0 0 1 1 1 1 TFIIF, beta subunit HTH domain TFIIF_beta_N PF17683.1 EMD63057.1 - 3.5e-21 76.3 0.0 9.2e-21 74.9 0.0 1.7 2 0 0 2 2 2 1 TFIIF, beta subunit N-terminus Tau95 PF09734.9 EMD63057.1 - 9.7e-06 26.4 0.9 1.6e-05 25.8 0.9 1.4 1 0 0 1 1 1 1 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain PCI PF01399.27 EMD63058.1 - 3.3e-13 50.0 0.0 8.7e-13 48.7 0.0 1.7 1 0 0 1 1 1 1 PCI domain RPN7 PF10602.9 EMD63058.1 - 8.4e-06 25.6 0.3 1.7e-05 24.6 0.3 1.5 1 0 0 1 1 1 1 26S proteasome subunit RPN7 TPR_19 PF14559.6 EMD63058.1 - 0.035 14.6 1.7 18 5.9 0.4 3.9 3 1 1 4 4 4 0 Tetratricopeptide repeat SNAP PF14938.6 EMD63058.1 - 0.068 12.6 0.8 0.12 11.8 0.8 1.4 1 0 0 1 1 1 0 Soluble NSF attachment protein, SNAP Ribosomal_L21p PF00829.21 EMD63059.1 - 6.1e-06 26.4 0.0 9.2e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 Ribosomal prokaryotic L21 protein Ribosomal_S8e PF01201.22 EMD63060.1 - 5.5e-47 159.4 3.1 8e-47 158.8 3.1 1.2 1 0 0 1 1 1 1 Ribosomal protein S8e WD40 PF00400.32 EMD63061.1 - 0.00084 20.1 2.4 0.058 14.3 0.3 4.2 4 0 0 4 4 4 1 WD domain, G-beta repeat DUF5449 PF17528.2 EMD63061.1 - 0.072 12.8 0.0 0.87 9.3 0.0 2.2 1 1 1 2 2 2 0 Family of unknown function (DUF5449) Chitin_synth_2 PF03142.15 EMD63062.1 - 1.4e-289 961.1 0.4 3.2e-289 959.9 0.1 1.6 2 0 0 2 2 2 1 Chitin synthase Glyco_trans_2_3 PF13632.6 EMD63062.1 - 2e-13 50.7 2.9 7.2e-13 48.9 2.9 2.0 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 EMD63062.1 - 1.5e-11 44.6 0.0 1.4e-09 38.2 0.0 2.4 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 EMD63062.1 - 0.00032 20.2 0.0 0.0039 16.7 0.0 2.2 2 0 0 2 2 2 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.26 EMD63062.1 - 0.0072 16.1 0.0 0.083 12.7 0.0 2.3 2 0 0 2 2 2 1 Glycosyl transferase family 2 BCA_ABC_TP_C PF12399.8 EMD63062.1 - 0.041 13.8 0.6 4.8 7.2 0.0 3.2 3 0 0 3 3 3 0 Branched-chain amino acid ATP-binding cassette transporter Sel1 PF08238.12 EMD63063.1 - 8.3e-41 137.5 27.4 8e-07 29.5 0.4 7.5 7 0 0 7 7 7 7 Sel1 repeat TPR_19 PF14559.6 EMD63063.1 - 9.5 6.8 11.1 6 7.5 0.1 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat Aminotran_1_2 PF00155.21 EMD63064.1 - 3.5e-21 75.8 0.0 4.6e-21 75.4 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.7 EMD63064.1 - 2.6e-06 26.5 0.0 6.6e-06 25.2 0.0 1.5 1 1 0 1 1 1 1 Alanine-glyoxylate amino-transferase Beta_elim_lyase PF01212.21 EMD63064.1 - 0.026 13.8 0.0 0.044 13.1 0.0 1.3 1 0 0 1 1 1 0 Beta-eliminating lyase DAD PF02109.16 EMD63065.1 - 4.5e-49 165.3 3.4 5.3e-49 165.1 3.4 1.0 1 0 0 1 1 1 1 DAD family DUF4389 PF14333.6 EMD63065.1 - 0.023 14.6 0.8 0.045 13.7 0.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4389) Tmemb_14 PF03647.13 EMD63066.1 - 1.5e-22 80.2 8.7 1.8e-22 79.9 8.7 1.1 1 0 0 1 1 1 1 Transmembrane proteins 14C CDH-cyt PF16010.5 EMD63067.1 - 3.4e-47 160.5 3.6 3.4e-47 160.5 3.6 2.2 2 0 0 2 2 2 1 Cytochrome domain of cellobiose dehydrogenase PD40 PF07676.12 EMD63067.1 - 0.039 13.9 0.0 0.27 11.2 0.0 2.4 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat Bac_luciferase PF00296.20 EMD63068.1 - 6.8e-67 226.1 0.1 9.8e-67 225.6 0.1 1.2 1 0 0 1 1 1 1 Luciferase-like monooxygenase Gpr1_Fun34_YaaH PF01184.19 EMD63069.1 - 2.5e-31 108.9 12.9 2.8e-31 108.7 12.9 1.0 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family DUF2244 PF10003.9 EMD63069.1 - 1.2 8.9 3.7 2.1 8.0 3.7 1.4 1 0 0 1 1 1 0 Integral membrane protein (DUF2244) Acyl-CoA_dh_2 PF08028.11 EMD63070.1 - 2e-10 41.1 1.1 2e-10 41.1 1.1 1.8 2 1 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 EMD63070.1 - 9.7e-05 23.0 0.1 0.00017 22.2 0.1 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 EMD63070.1 - 0.00012 22.2 0.1 0.00039 20.6 0.0 1.9 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.24 EMD63070.1 - 0.0023 18.1 1.0 0.0061 16.8 0.1 2.1 2 1 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain tRNA-synt_2 PF00152.20 EMD63071.1 - 2.2e-73 247.1 0.0 3.6e-73 246.4 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) DUF2156 PF09924.9 EMD63071.1 - 6.5e-16 58.2 0.0 9.7e-16 57.6 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2156) tRNA_anti-codon PF01336.25 EMD63071.1 - 4.7e-05 23.3 0.0 0.00011 22.1 0.0 1.6 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 EMD63071.1 - 0.0074 15.8 0.3 1.2 8.5 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) LTXXQ PF07813.12 EMD63071.1 - 0.013 16.2 3.7 0.038 14.7 3.7 1.8 1 0 0 1 1 1 0 LTXXQ motif family protein MCM_N PF14551.6 EMD63071.1 - 0.067 13.8 0.0 0.2 12.2 0.0 1.8 1 0 0 1 1 1 0 MCM N-terminal domain Hid1 PF12722.7 EMD63071.1 - 0.77 7.8 6.3 1.1 7.3 6.3 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein p450 PF00067.22 EMD63072.1 - 4e-98 329.2 0.0 4.6e-98 329.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Peptidase_M1 PF01433.20 EMD63073.1 - 0.0026 17.4 0.2 0.0049 16.4 0.2 1.4 1 0 0 1 1 1 1 Peptidase family M1 domain Peptidase_M1_N PF17900.1 EMD63073.1 - 0.0034 17.6 0.0 0.73 10.0 0.0 2.5 2 0 0 2 2 2 2 Peptidase M1 N-terminal domain HEAT_2 PF13646.6 EMD63073.1 - 0.068 13.6 0.6 2.2 8.7 0.3 3.0 2 1 1 3 3 3 0 HEAT repeats PHD PF00628.29 EMD63074.1 - 0.0018 18.1 1.5 0.0018 18.1 1.5 1.8 2 0 0 2 2 2 1 PHD-finger zf-CSL PF05207.13 EMD63074.1 - 0.026 14.3 0.4 0.3 10.8 0.1 2.3 2 0 0 2 2 2 0 CSL zinc finger Prok-RING_1 PF14446.6 EMD63074.1 - 0.067 13.1 3.5 0.51 10.3 0.7 2.3 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 AT_hook PF02178.19 EMD63074.1 - 1.6 8.8 10.1 8.1 6.7 0.5 3.1 2 0 0 2 2 2 0 AT hook motif PH PF00169.29 EMD63075.1 - 0.00027 21.4 0.1 0.0015 19.0 0.0 2.2 2 0 0 2 2 2 1 PH domain EthD PF07110.11 EMD63076.1 - 0.014 16.5 1.2 0.19 12.9 1.2 2.1 1 1 0 1 1 1 0 EthD domain Phage_cap_P2 PF05125.12 EMD63076.1 - 0.1 11.6 0.0 0.13 11.3 0.0 1.1 1 0 0 1 1 1 0 Phage major capsid protein, P2 family WSC PF01822.19 EMD63077.1 - 7e-10 39.0 2.1 7e-10 39.0 2.1 2.2 1 1 1 2 2 2 1 WSC domain OPT PF03169.15 EMD63078.1 - 6.4e-178 593.2 52.9 7.3e-178 593.0 52.9 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Glyco_hydro_62 PF03664.13 EMD63079.1 - 1.6e-51 175.3 2.8 1.9e-51 175.0 2.8 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 62 Fuseless PF15993.5 EMD63079.1 - 0.039 13.2 0.2 0.083 12.1 0.0 1.5 2 0 0 2 2 2 0 Fuseless Sel1 PF08238.12 EMD63080.1 - 2.6e-12 47.0 14.9 6.6e-05 23.5 0.2 3.8 4 0 0 4 4 4 3 Sel1 repeat TPR_6 PF13174.6 EMD63080.1 - 0.52 11.1 1.9 1.2e+02 3.6 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 EMD63080.1 - 1.1 9.9 5.5 1.2 9.9 0.8 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF1776 PF08643.10 EMD63081.1 - 8.1e-89 297.9 0.0 9.9e-89 297.6 0.0 1.1 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) adh_short PF00106.25 EMD63081.1 - 0.00038 20.0 0.0 0.00065 19.2 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase CAP_N PF01213.19 EMD63081.1 - 0.11 12.0 0.2 0.18 11.2 0.2 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal WLM PF08325.10 EMD63082.1 - 7.9e-56 189.2 0.4 1.1e-55 188.7 0.4 1.2 1 0 0 1 1 1 1 WLM domain DZR PF12773.7 EMD63082.1 - 3e-05 23.9 1.2 0.00012 22.0 1.2 1.9 1 1 0 1 1 1 1 Double zinc ribbon zf-RanBP PF00641.18 EMD63082.1 - 0.0028 16.9 0.6 0.0028 16.9 0.6 3.1 3 0 0 3 3 3 1 Zn-finger in Ran binding protein and others SprT-like PF10263.9 EMD63082.1 - 0.04 13.8 0.0 0.074 12.9 0.0 1.5 1 0 0 1 1 1 0 SprT-like family DUF45 PF01863.17 EMD63082.1 - 0.088 12.8 0.5 0.2 11.7 0.5 1.5 1 0 0 1 1 1 0 Protein of unknown function DUF45 zf-Sec23_Sec24 PF04810.15 EMD63082.1 - 1.2 9.2 8.2 3.2 7.9 0.1 2.8 2 1 0 2 2 2 0 Sec23/Sec24 zinc finger PRIMA1 PF16101.5 EMD63083.1 - 1.2 9.2 6.9 3.5 7.7 6.9 1.8 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Scm3 PF10384.9 EMD63084.1 - 4.4e-18 64.8 0.3 1e-17 63.6 0.3 1.7 1 0 0 1 1 1 1 Centromere protein Scm3 zf-C2H2_jaz PF12171.8 EMD63084.1 - 0.0011 19.1 0.1 0.003 17.8 0.1 1.6 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.26 EMD63084.1 - 0.0027 18.1 0.3 0.0066 16.8 0.3 1.6 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMD63084.1 - 0.0028 18.4 0.1 0.0083 16.9 0.1 1.8 1 0 0 1 1 1 1 C2H2-type zinc finger zf-met PF12874.7 EMD63084.1 - 0.0063 16.9 0.1 0.013 15.8 0.1 1.6 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2HC_2 PF13913.6 EMD63084.1 - 0.072 13.0 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 zinc-finger of a C2HC-type APG6 PF04111.12 EMD63085.1 - 4.1e-69 232.1 0.0 7.1e-69 231.3 0.0 1.4 1 0 0 1 1 1 1 Apg6 BARA domain APG6_N PF17675.1 EMD63085.1 - 9.2e-38 129.8 6.1 1.5e-37 129.1 6.1 1.4 1 0 0 1 1 1 1 Apg6 coiled-coil region GOLGA2L5 PF15070.6 EMD63085.1 - 0.011 14.4 4.6 0.016 13.9 4.6 1.1 1 0 0 1 1 1 0 Putative golgin subfamily A member 2-like protein 5 HOOK PF05622.12 EMD63085.1 - 0.031 12.5 4.1 0.044 12.0 4.1 1.1 1 0 0 1 1 1 0 HOOK protein DUF4472 PF14739.6 EMD63085.1 - 0.031 15.0 5.3 0.076 13.7 5.3 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4472) DUF4600 PF15372.6 EMD63085.1 - 0.049 14.1 2.1 0.098 13.1 2.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4600) HAUS-augmin3 PF14932.6 EMD63085.1 - 0.065 12.8 6.8 0.1 12.1 6.8 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 HIP1_clath_bdg PF16515.5 EMD63085.1 - 0.066 13.8 5.8 0.15 12.7 1.8 2.5 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF2968 PF11180.8 EMD63085.1 - 0.66 9.6 10.0 1.2 8.7 10.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) UPF0242 PF06785.11 EMD63085.1 - 3.2 7.8 6.5 3.7 7.6 5.4 1.7 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus F-box-like PF12937.7 EMD63086.1 - 0.052 13.5 0.0 0.52 10.3 0.0 2.8 2 1 0 2 2 2 0 F-box-like F-box PF00646.33 EMD63086.1 - 0.14 12.0 0.7 3 7.8 0.2 2.9 2 0 0 2 2 2 0 F-box domain LRR_6 PF13516.6 EMD63086.1 - 0.21 11.8 1.2 8.1 6.8 0.0 3.7 4 0 0 4 4 4 0 Leucine Rich repeat LRR_4 PF12799.7 EMD63086.1 - 1.1 9.8 3.0 99 3.6 0.0 4.0 4 1 1 5 5 5 0 Leucine Rich repeats (2 copies) FMN_red PF03358.15 EMD63087.1 - 1.6e-12 47.4 0.0 2.4e-12 46.9 0.0 1.3 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 EMD63087.1 - 5.4e-07 29.5 0.0 7.2e-07 29.1 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin-like fold Flavodoxin_1 PF00258.25 EMD63087.1 - 0.00085 19.6 0.1 0.022 14.9 0.1 2.3 1 1 0 1 1 1 1 Flavodoxin Flavodoxin_5 PF12724.7 EMD63087.1 - 0.017 15.3 0.0 0.12 12.6 0.0 2.0 1 1 1 2 2 2 0 Flavodoxin domain Phosphodiest PF01663.22 EMD63088.1 - 6.2e-93 312.2 1.8 8.3e-93 311.8 1.8 1.2 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 EMD63088.1 - 0.00033 20.1 0.3 0.059 12.8 0.0 2.2 1 1 0 2 2 2 2 Sulfatase DUF2063 PF09836.9 EMD63088.1 - 0.076 13.2 0.0 0.2 11.9 0.0 1.6 1 0 0 1 1 1 0 Putative DNA-binding domain eIF-3_zeta PF05091.12 EMD63090.1 - 6.8e-208 691.9 0.0 8e-208 691.6 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) VMA21 PF09446.10 EMD63091.1 - 9.7e-15 54.4 11.3 1.3e-14 54.0 11.3 1.2 1 0 0 1 1 1 1 VMA21-like domain TMEM100 PF16311.5 EMD63091.1 - 0.088 12.4 0.0 0.1 12.2 0.0 1.1 1 0 0 1 1 1 0 Transmembrane protein 100 SNF2_N PF00176.23 EMD63092.1 - 7.7e-37 126.8 1.5 1.5e-17 63.4 0.0 2.3 1 1 1 2 2 2 2 SNF2 family N-terminal domain Helicase_C PF00271.31 EMD63092.1 - 9e-21 74.3 0.0 6.7e-17 61.8 0.0 2.7 2 0 0 2 2 2 2 Helicase conserved C-terminal domain ResIII PF04851.15 EMD63092.1 - 2.3e-05 24.4 0.0 7.6e-05 22.8 0.0 1.9 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SH3BGR PF04908.15 EMD63093.1 - 0.0032 17.6 0.0 0.0032 17.6 0.0 3.2 3 0 0 3 3 3 1 SH3-binding, glutamic acid-rich protein bZIP_1 PF00170.21 EMD63094.1 - 0.00011 22.2 9.2 0.00018 21.5 9.2 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EMD63094.1 - 0.032 14.3 5.1 0.032 14.3 5.1 1.9 1 1 1 2 2 2 0 Basic region leucine zipper Aldo_ket_red PF00248.21 EMD63095.1 - 4.5e-69 232.9 0.0 5.1e-69 232.7 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Pkinase PF00069.25 EMD63097.1 - 0.0011 18.4 0.2 0.0087 15.5 0.2 2.1 1 1 0 1 1 1 1 Protein kinase domain p450 PF00067.22 EMD63098.1 - 8.6e-60 202.8 0.0 1.1e-59 202.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 MFS_1 PF07690.16 EMD63099.1 - 6.3e-34 117.4 40.8 6.3e-34 117.4 40.8 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily SLATT_2 PF18183.1 EMD63099.1 - 0.14 11.9 0.1 0.23 11.2 0.1 1.2 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain 2 Wzz PF02706.15 EMD63099.1 - 9.5 6.6 6.6 0.89 9.9 0.1 2.5 3 0 0 3 3 3 0 Chain length determinant protein Rhabdo_M1 PF03342.13 EMD63100.1 - 0.078 12.3 0.2 0.68 9.2 0.0 2.1 2 0 0 2 2 2 0 Rhabdovirus M1 matrix protein (M1 polymerase-associated protein) SF3b1 PF08920.10 EMD63101.1 - 4e-21 75.7 12.4 8.7e-20 71.4 12.4 2.6 1 1 0 1 1 1 1 Splicing factor 3B subunit 1 HEAT PF02985.22 EMD63101.1 - 3.3e-13 48.7 7.0 0.0012 19.0 0.1 9.4 11 0 0 11 11 10 2 HEAT repeat HEAT_EZ PF13513.6 EMD63101.1 - 3.4e-13 49.8 5.2 0.00097 19.6 0.0 7.3 7 1 0 7 7 7 3 HEAT-like repeat HEAT_2 PF13646.6 EMD63101.1 - 4.5e-13 49.4 12.6 0.3 11.5 0.0 8.1 5 1 2 8 8 8 6 HEAT repeats Cnd1 PF12717.7 EMD63101.1 - 1.2e-07 31.9 8.4 0.3 11.1 0.0 6.7 5 3 1 6 6 6 2 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 EMD63101.1 - 2.1e-07 29.9 1.2 0.11 11.1 0.3 3.5 2 1 0 3 3 3 3 Adaptin N terminal region Vac14_Fab1_bd PF12755.7 EMD63101.1 - 3.6e-07 30.7 3.0 0.33 11.6 0.0 6.1 6 1 0 6 6 6 2 Vacuolar 14 Fab1-binding region NUC173 PF08161.12 EMD63101.1 - 0.00024 20.8 0.3 1.8 8.2 0.0 5.1 4 1 2 6 6 6 1 NUC173 domain UNC45-central PF11701.8 EMD63101.1 - 0.00063 19.7 0.0 0.0024 17.8 0.0 1.9 2 0 0 2 2 2 1 Myosin-binding striated muscle assembly central CLASP_N PF12348.8 EMD63101.1 - 0.00091 18.9 0.1 0.97 8.9 0.0 4.0 4 0 0 4 4 4 1 CLASP N terminal DUF3385 PF11865.8 EMD63101.1 - 0.0019 18.1 6.0 0.044 13.7 0.2 4.6 4 1 0 5 5 5 1 Domain of unknown function (DUF3385) UME PF08064.13 EMD63101.1 - 0.003 17.5 0.1 8.7 6.3 0.0 4.5 5 1 1 6 6 6 1 UME (NUC010) domain CRM1_C PF08767.11 EMD63101.1 - 0.012 14.8 0.1 0.034 13.3 0.1 1.8 1 0 0 1 1 1 0 CRM1 C terminal GFA PF04828.14 EMD63102.1 - 4.5e-07 30.1 0.7 4.5e-07 30.1 0.7 1.6 2 0 0 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme Kre28 PF17097.5 EMD63103.1 - 0.0078 15.2 1.0 0.01 14.9 1.0 1.1 1 0 0 1 1 1 1 Spindle pole body component Use1 PF09753.9 EMD63103.1 - 0.013 15.2 5.5 0.54 9.9 0.4 2.2 1 1 0 2 2 2 0 Membrane fusion protein Use1 DUF4407 PF14362.6 EMD63103.1 - 0.023 14.1 1.3 0.032 13.6 1.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) PI3K_1B_p101 PF10486.9 EMD63103.1 - 0.052 11.3 2.4 0.07 10.9 2.4 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit NPV_P10 PF05531.12 EMD63103.1 - 0.17 12.4 2.9 4.4 7.9 0.7 2.9 1 1 2 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF1664 PF07889.12 EMD63103.1 - 0.21 11.6 2.7 0.28 11.2 0.8 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF948 PF06103.11 EMD63103.1 - 0.57 10.5 4.3 5.5 7.3 0.7 3.5 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) FUSC PF04632.12 EMD63103.1 - 2.3 6.6 6.5 15 3.9 7.2 1.8 1 1 1 2 2 2 0 Fusaric acid resistance protein family Cgr1 PF03879.14 EMD63104.1 - 5e-31 107.3 36.7 5.7e-31 107.1 36.7 1.0 1 0 0 1 1 1 1 Cgr1 family Mito_carr PF00153.27 EMD63105.1 - 2.7e-62 206.7 0.6 5.8e-21 74.2 0.1 3.7 3 0 0 3 3 3 3 Mitochondrial carrier protein Tim17 PF02466.19 EMD63105.1 - 3.9e-13 49.7 9.4 5.8e-12 46.0 0.3 2.9 2 1 0 2 2 2 2 Tim17/Tim22/Tim23/Pmp24 family PcfK PF14058.6 EMD63107.1 - 0.071 13.4 1.2 0.17 12.2 1.2 1.6 1 0 0 1 1 1 0 PcfK-like protein Reo_sigma1 PF01664.16 EMD63108.1 - 0.016 14.6 0.4 0.027 13.8 0.4 1.3 1 0 0 1 1 1 0 Reovirus viral attachment protein sigma 1 Wzy_C PF04932.15 EMD63108.1 - 2.4 7.8 10.2 0.063 12.9 1.3 2.5 2 1 1 3 3 3 0 O-Antigen ligase Vps8 PF12816.7 EMD63111.1 - 2e-68 229.8 0.2 3.6e-68 229.0 0.2 1.5 1 0 0 1 1 1 1 Golgi CORVET complex core vacuolar protein 8 Clathrin PF00637.20 EMD63111.1 - 1.5e-08 34.6 1.9 0.013 15.4 1.4 3.5 3 0 0 3 3 3 3 Region in Clathrin and VPS zf-RING_11 PF17123.5 EMD63111.1 - 0.062 13.0 0.8 0.13 12.0 0.0 2.0 2 0 0 2 2 2 0 RING-like zinc finger zf-C3H2C3 PF17122.5 EMD63111.1 - 0.11 12.6 2.3 0.11 12.5 0.1 2.1 2 0 0 2 2 2 0 Zinc-finger DUF3752 PF12572.8 EMD63112.1 - 6.3e-49 166.4 14.0 6.3e-49 166.4 14.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3752) Dynamitin PF04912.14 EMD63112.1 - 0.016 14.6 1.5 0.022 14.1 1.5 1.2 1 0 0 1 1 1 0 Dynamitin FAD_binding_4 PF01565.23 EMD63114.1 - 1.2e-22 80.2 0.6 1.9e-22 79.5 0.6 1.3 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EMD63114.1 - 9.6e-08 32.0 0.0 2.6e-07 30.6 0.0 1.8 1 0 0 1 1 1 1 Berberine and berberine like SMC_N PF02463.19 EMD63115.1 - 4.6e-57 193.0 30.9 4.8e-56 189.7 30.9 2.6 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EMD63115.1 - 1.7e-21 76.7 1.2 7.5e-21 74.6 0.2 2.8 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 EMD63115.1 - 5.5e-09 36.3 4.5 0.00043 20.2 0.0 3.0 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 EMD63115.1 - 1.9e-08 35.0 16.0 1.9e-08 35.0 16.0 6.8 2 2 3 5 5 5 1 AAA domain MscS_porin PF12795.7 EMD63115.1 - 0.00023 20.8 30.9 0.00023 20.8 30.9 5.6 2 2 3 6 6 6 1 Mechanosensitive ion channel porin domain AAA_29 PF13555.6 EMD63115.1 - 0.00093 18.9 0.1 0.003 17.3 0.1 1.8 2 0 0 2 2 2 1 P-loop containing region of AAA domain TMF_DNA_bd PF12329.8 EMD63115.1 - 0.0012 18.8 9.1 0.0012 18.8 9.1 10.5 5 3 4 10 10 10 1 TATA element modulatory factor 1 DNA binding HIP1_clath_bdg PF16515.5 EMD63115.1 - 0.0033 18.0 12.9 0.0033 18.0 12.9 9.5 3 2 6 9 9 9 1 Clathrin-binding domain of Huntingtin-interacting protein 1 ABC_tran PF00005.27 EMD63115.1 - 0.046 14.2 0.0 0.046 14.2 0.0 6.2 3 2 1 4 4 4 0 ABC transporter EF-hand_2 PF09068.11 EMD63115.1 - 5.3 7.2 6.9 0.84 9.8 1.0 2.8 2 0 0 2 2 2 0 EF hand LEA_3 PF03242.13 EMD63116.1 - 0.0053 17.5 0.5 0.024 15.4 0.5 2.2 1 0 0 1 1 1 1 Late embryogenesis abundant protein DUF4880 PF16220.5 EMD63116.1 - 0.093 12.6 2.5 0.35 10.8 2.5 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4880) HD_3 PF13023.6 EMD63117.1 - 2.9e-48 163.9 0.1 4e-48 163.5 0.1 1.2 1 0 0 1 1 1 1 HD domain HD_2 PF12917.7 EMD63117.1 - 7.1e-11 42.2 0.0 9.7e-11 41.8 0.0 1.2 1 0 0 1 1 1 1 HD containing hydrolase-like enzyme HAUS6_N PF14661.6 EMD63118.1 - 5.2e-48 163.6 2.5 5.2e-48 163.6 2.5 2.1 2 0 0 2 2 2 1 HAUS augmin-like complex subunit 6 N-terminus P4Ha_N PF08336.11 EMD63118.1 - 0.34 10.9 2.0 0.39 10.7 0.3 1.9 2 0 0 2 2 2 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region APG6_N PF17675.1 EMD63118.1 - 0.74 10.3 7.2 6.7 7.3 0.5 2.3 2 0 0 2 2 2 0 Apg6 coiled-coil region Glyco_transf_90 PF05686.12 EMD63119.1 - 2e-15 56.7 0.6 1.9e-11 43.5 0.2 2.9 2 1 0 2 2 2 2 Glycosyl transferase family 90 DUF3917 PF13055.6 EMD63119.1 - 0.067 13.6 0.4 0.22 12.0 0.4 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3917) Colicin_V PF02674.16 EMD63119.1 - 0.098 12.6 0.0 0.098 12.6 0.0 3.2 2 1 1 3 3 3 0 Colicin V production protein DUF4131 PF13567.6 EMD63119.1 - 1.1 8.9 15.0 7.8 6.1 0.5 4.2 3 1 1 4 4 4 0 Domain of unknown function (DUF4131) MFS_1 PF07690.16 EMD63120.1 - 1.6e-18 66.7 30.7 2.1e-18 66.4 29.5 1.7 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EMD63120.1 - 0.0001 21.3 6.1 0.0001 21.3 6.1 2.4 2 0 0 2 2 2 2 Sugar (and other) transporter LapA_dom PF06305.11 EMD63120.1 - 0.14 11.9 3.4 18 5.2 1.6 3.1 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain NAD_binding_2 PF03446.15 EMD63121.1 - 9.7e-31 107.1 0.1 1.6e-30 106.4 0.1 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 EMD63121.1 - 1.3e-11 44.9 0.0 2.7e-11 43.9 0.0 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.20 EMD63121.1 - 1.1e-09 38.5 0.0 2.5e-09 37.3 0.0 1.6 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase NAD_binding_11 PF14833.6 EMD63121.1 - 1.2e-07 31.9 0.1 2.4e-07 31.0 0.1 1.5 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase NAD_binding_10 PF13460.6 EMD63121.1 - 9.8e-06 25.6 0.4 2.1e-05 24.5 0.1 1.6 2 0 0 2 2 2 1 NAD(P)H-binding UDPG_MGDP_dh_N PF03721.14 EMD63121.1 - 6.7e-05 22.6 0.4 0.00029 20.5 0.4 2.0 2 1 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain GFO_IDH_MocA PF01408.22 EMD63121.1 - 0.00038 21.3 0.0 0.00074 20.3 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Sacchrp_dh_NADP PF03435.18 EMD63121.1 - 0.00039 20.7 0.1 0.00086 19.6 0.1 1.6 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain IlvN PF07991.12 EMD63121.1 - 0.00078 19.1 0.7 0.0034 17.0 0.1 2.2 3 0 0 3 3 3 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain Semialdhyde_dh PF01118.24 EMD63121.1 - 0.0048 17.3 0.0 0.0087 16.5 0.0 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain OCD_Mu_crystall PF02423.15 EMD63121.1 - 0.0051 15.8 0.0 0.0074 15.3 0.0 1.3 1 0 0 1 1 1 1 Ornithine cyclodeaminase/mu-crystallin family KR PF08659.10 EMD63121.1 - 0.012 15.6 0.2 0.024 14.5 0.0 1.6 2 0 0 2 2 2 0 KR domain PDH PF02153.17 EMD63121.1 - 0.015 14.3 0.2 0.022 13.8 0.2 1.2 1 0 0 1 1 1 0 Prephenate dehydrogenase TrkA_N PF02254.18 EMD63121.1 - 0.023 14.9 1.1 0.087 13.1 0.5 2.2 2 1 0 2 2 2 0 TrkA-N domain Glu_dehyd_C PF16912.5 EMD63121.1 - 0.076 12.5 0.1 0.15 11.5 0.1 1.4 1 0 0 1 1 1 0 Glucose dehydrogenase C-terminus Ham1p_like PF01725.16 EMD63121.1 - 0.086 12.7 0.0 0.18 11.7 0.0 1.5 1 0 0 1 1 1 0 Ham1 family NAT PF04768.13 EMD63122.1 - 1.4e-54 184.3 0.0 4.2e-53 179.5 0.0 2.4 2 0 0 2 2 2 2 NAT, N-acetyltransferase, of N-acetylglutamate synthase SnoaL_2 PF12680.7 EMD63123.1 - 0.069 13.8 0.1 0.093 13.4 0.1 1.2 1 0 0 1 1 1 0 SnoaL-like domain Herpes_LMP2 PF07415.11 EMD63125.1 - 0.045 12.5 0.0 0.072 11.9 0.0 1.2 1 0 0 1 1 1 0 Gammaherpesvirus latent membrane protein (LMP2) protein DUF3245 PF11595.8 EMD63125.1 - 0.062 13.8 0.2 0.13 12.8 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3245) PBP1_TM PF14812.6 EMD63125.1 - 0.95 9.9 6.7 0.13 12.7 0.6 2.6 2 1 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Pro_isomerase PF00160.21 EMD63126.1 - 2.6e-49 167.5 0.4 2.9e-49 167.4 0.4 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD p450 PF00067.22 EMD63127.1 - 7.4e-62 209.6 0.0 1e-61 209.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 FAD_binding_3 PF01494.19 EMD63128.1 - 9.1e-14 51.5 2.7 3.5e-11 43.0 2.7 3.1 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.24 EMD63128.1 - 4.8e-09 36.3 1.0 0.0007 19.3 0.2 2.2 1 1 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EMD63128.1 - 2.5e-08 33.5 0.1 0.00069 18.9 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EMD63128.1 - 7.2e-08 31.9 0.0 1.1e-07 31.3 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 EMD63128.1 - 2.8e-06 27.5 0.1 8e-06 26.0 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 EMD63128.1 - 2.8e-06 26.3 0.2 0.00065 18.5 0.1 2.2 2 0 0 2 2 2 2 HI0933-like protein GIDA PF01134.22 EMD63128.1 - 0.00013 21.2 0.1 0.0038 16.4 0.1 2.2 2 0 0 2 2 2 1 Glucose inhibited division protein A Lycopene_cycl PF05834.12 EMD63128.1 - 0.00018 20.7 0.3 0.05 12.6 0.0 2.4 2 0 0 2 2 2 2 Lycopene cyclase protein FAD_oxidored PF12831.7 EMD63128.1 - 0.0002 20.9 1.3 0.00021 20.8 0.2 1.7 2 1 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EMD63128.1 - 0.0017 17.7 0.0 0.012 14.9 0.0 2.0 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 EMD63128.1 - 0.0043 16.4 0.0 0.0084 15.4 0.0 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox PF00070.27 EMD63128.1 - 0.0061 17.1 0.0 0.019 15.5 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 EMD63128.1 - 0.0075 15.6 0.1 0.36 10.0 0.1 2.2 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase Thi4 PF01946.17 EMD63128.1 - 0.016 14.5 0.0 0.03 13.5 0.0 1.4 1 0 0 1 1 1 0 Thi4 family GTP_cyclohydroI PF01227.22 EMD63129.1 - 0.0089 15.5 0.6 0.014 14.9 0.6 1.4 1 0 0 1 1 1 1 GTP cyclohydrolase I OSK PF17182.4 EMD63130.1 - 0.21 10.8 0.0 0.31 10.2 0.0 1.3 1 0 0 1 1 1 0 OSK domain NmrA PF05368.13 EMD63131.1 - 3.9e-29 101.9 0.0 5.4e-29 101.4 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EMD63131.1 - 1.5e-12 47.8 0.0 1.9e-12 47.4 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EMD63131.1 - 9.9e-07 28.5 0.0 1.6e-06 27.7 0.0 1.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EMD63131.1 - 0.078 12.4 0.0 0.12 11.8 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase KR PF08659.10 EMD63131.1 - 0.086 12.8 0.1 0.14 12.1 0.1 1.3 1 0 0 1 1 1 0 KR domain Semialdhyde_dh PF01118.24 EMD63131.1 - 0.13 12.7 0.1 0.29 11.6 0.1 1.7 1 1 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain DUF2709 PF10915.8 EMD63131.1 - 0.15 11.3 0.1 0.6 9.3 0.0 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2709) PALP PF00291.25 EMD63132.1 - 6.8e-64 216.1 0.3 8.6e-64 215.8 0.3 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme CBS PF00571.28 EMD63132.1 - 1.2e-14 54.5 0.0 2.1e-09 37.7 0.0 3.2 3 0 0 3 3 3 2 CBS domain SRPRB PF09439.10 EMD63133.1 - 6.8e-30 103.8 0.0 3e-29 101.7 0.0 1.8 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_16 PF13191.6 EMD63133.1 - 4e-05 24.1 1.7 0.00089 19.7 1.7 2.5 1 1 0 1 1 1 1 AAA ATPase domain Arf PF00025.21 EMD63133.1 - 7.4e-05 22.3 0.0 0.00018 21.0 0.0 1.6 2 0 0 2 2 2 1 ADP-ribosylation factor family AAA PF00004.29 EMD63133.1 - 0.00023 21.6 0.0 0.0004 20.8 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) MMR_HSR1 PF01926.23 EMD63133.1 - 0.00036 20.6 0.0 0.00063 19.8 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EMD63133.1 - 0.00075 18.9 0.0 0.0048 16.3 0.0 1.9 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region ATP_bind_1 PF03029.17 EMD63133.1 - 0.00091 19.1 0.0 0.088 12.6 0.0 2.2 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein AAA_22 PF13401.6 EMD63133.1 - 0.02 15.2 0.0 0.038 14.3 0.0 1.6 1 1 0 1 1 1 0 AAA domain GTP_EFTU PF00009.27 EMD63133.1 - 0.037 13.6 0.0 0.46 10.0 0.0 2.2 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain G-alpha PF00503.20 EMD63133.1 - 0.037 13.2 0.0 2 7.5 0.0 2.1 1 1 0 2 2 2 0 G-protein alpha subunit Sigma54_activat PF00158.26 EMD63133.1 - 0.1 12.3 0.0 0.28 10.9 0.0 1.6 2 0 0 2 2 2 0 Sigma-54 interaction domain NACHT PF05729.12 EMD63133.1 - 0.12 12.3 0.0 1.8 8.5 0.0 2.2 2 0 0 2 2 2 0 NACHT domain AAA_5 PF07728.14 EMD63133.1 - 0.14 12.1 0.0 0.27 11.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_29 PF13555.6 EMD63133.1 - 0.15 11.8 0.5 0.34 10.7 0.0 1.8 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_7 PF12775.7 EMD63133.1 - 0.16 11.4 0.0 0.27 10.7 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_33 PF13671.6 EMD63133.1 - 0.2 11.8 0.3 0.48 10.6 0.3 1.5 1 1 0 1 1 1 0 AAA domain Roc PF08477.13 EMD63133.1 - 0.21 11.8 0.0 1.6 9.0 0.0 2.3 1 1 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase NDT80_PhoG PF05224.12 EMD63135.1 - 4.8e-38 131.2 0.2 7.2e-38 130.7 0.2 1.3 1 0 0 1 1 1 1 NDT80 / PhoG like DNA-binding family NOT2_3_5 PF04153.18 EMD63136.1 - 1.3e-26 93.3 0.3 2.4e-26 92.4 0.3 1.5 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family Fungal_trans PF04082.18 EMD63137.1 - 3.8e-32 111.4 0.0 6.6e-32 110.6 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD63137.1 - 4.6e-09 36.3 8.2 7.3e-09 35.6 8.2 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain NUDIX PF00293.28 EMD63138.1 - 1.4e-21 76.9 0.6 2e-21 76.4 0.6 1.1 1 0 0 1 1 1 1 NUDIX domain NUDIX_4 PF14815.6 EMD63138.1 - 0.0045 17.0 0.1 0.0085 16.1 0.0 1.5 1 1 0 1 1 1 1 NUDIX domain PaO PF08417.12 EMD63138.1 - 0.011 15.9 0.0 7.7 6.7 0.0 2.9 1 1 0 2 2 2 0 Pheophorbide a oxygenase LysM PF01476.20 EMD63140.1 - 0.002 18.1 0.0 0.0064 16.5 0.0 1.9 1 0 0 1 1 1 1 LysM domain Peptidase_M1 PF01433.20 EMD63141.1 - 4.3e-42 144.1 0.1 6.9e-42 143.5 0.1 1.2 1 0 0 1 1 1 1 Peptidase family M1 domain Leuk-A4-hydro_C PF09127.11 EMD63141.1 - 4.4e-38 129.8 0.1 1.1e-37 128.6 0.1 1.7 1 0 0 1 1 1 1 Leukotriene A4 hydrolase, C-terminal Peptidase_M1_N PF17900.1 EMD63141.1 - 1.2e-29 103.8 0.0 1.9e-29 103.2 0.0 1.3 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain Peptidase_M61 PF05299.12 EMD63141.1 - 0.33 11.4 3.7 2.3 8.6 2.1 2.6 2 1 0 2 2 2 0 M61 glycyl aminopeptidase LacAB_rpiB PF02502.18 EMD63142.1 - 8.3e-45 152.2 0.0 1.2e-44 151.7 0.0 1.2 1 0 0 1 1 1 1 Ribose/Galactose Isomerase Gly_rich_SFCGS PF14272.6 EMD63142.1 - 0.11 12.5 0.5 0.69 9.9 0.0 2.5 3 1 0 3 3 3 0 Glycine-rich SFCGS DUF4514 PF14986.6 EMD63142.1 - 0.36 10.8 2.0 0.71 9.9 1.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4514) Rhodanese PF00581.20 EMD63143.1 - 1.8e-11 44.5 0.1 3.4e-11 43.6 0.1 1.4 1 1 0 1 1 1 1 Rhodanese-like domain Thioredoxin PF00085.20 EMD63144.1 - 3.6e-46 155.4 1.0 4.4e-25 87.7 0.0 4.4 3 2 0 3 3 3 2 Thioredoxin Thioredoxin_6 PF13848.6 EMD63144.1 - 4.3e-10 39.8 0.0 0.00034 20.6 0.0 4.2 2 1 2 4 4 4 2 Thioredoxin-like domain Thioredoxin_8 PF13905.6 EMD63144.1 - 4.1e-08 33.5 0.1 0.012 15.9 0.0 3.7 3 0 0 3 3 3 2 Thioredoxin-like HyaE PF07449.11 EMD63144.1 - 0.006 16.5 0.0 5.7 7.0 0.0 3.5 3 0 0 3 3 3 1 Hydrogenase-1 expression protein HyaE OST3_OST6 PF04756.13 EMD63144.1 - 0.014 14.8 0.1 2.8 7.2 0.1 2.9 3 0 0 3 3 3 0 OST3 / OST6 family, transporter family Thioredoxin_7 PF13899.6 EMD63144.1 - 0.045 13.9 0.2 0.58 10.4 0.1 2.8 3 0 0 3 3 3 0 Thioredoxin-like Thioredoxin_9 PF14595.6 EMD63144.1 - 0.083 12.7 0.6 5.5 6.8 0.0 3.2 3 0 0 3 3 3 0 Thioredoxin ETC_C1_NDUFA5 PF04716.14 EMD63145.1 - 1.1e-26 92.4 0.0 1.1e-25 89.2 0.0 2.3 2 0 0 2 2 2 1 ETC complex I subunit conserved region CMD PF02627.20 EMD63148.1 - 0.13 12.4 0.5 0.24 11.5 0.5 1.5 1 0 0 1 1 1 0 Carboxymuconolactone decarboxylase family Fungal_trans PF04082.18 EMD63150.1 - 9.6e-20 70.7 0.1 1.8e-19 69.8 0.1 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-H2C2_2 PF13465.6 EMD63150.1 - 3.7e-09 36.6 11.3 9.1e-07 29.0 4.1 2.8 2 0 0 2 2 2 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMD63150.1 - 0.00037 21.1 17.7 0.036 14.9 6.0 3.1 2 0 0 2 2 2 2 C2H2-type zinc finger zf-Di19 PF05605.12 EMD63150.1 - 0.01 16.1 4.9 0.023 15.0 4.9 1.6 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2 PF00096.26 EMD63150.1 - 0.039 14.4 17.7 0.39 11.3 7.8 2.8 2 0 0 2 2 2 0 Zinc finger, C2H2 type Suf PF05843.14 EMD63150.1 - 0.077 13.0 10.7 0.18 11.8 10.7 1.6 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Zn_Tnp_IS1595 PF12760.7 EMD63150.1 - 0.83 9.7 3.3 2.2 8.3 3.3 1.8 1 0 0 1 1 1 0 Transposase zinc-ribbon domain DUF4175 PF13779.6 EMD63150.1 - 0.83 7.5 22.3 2.2 6.1 22.3 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) TMEM51 PF15345.6 EMD63150.1 - 1.1 9.0 9.9 2.5 7.9 9.9 1.5 1 0 0 1 1 1 0 Transmembrane protein 51 CCDC53 PF10152.9 EMD63150.1 - 4.7 7.6 12.1 0.21 12.0 5.3 2.3 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex eIF-3_zeta PF05091.12 EMD63150.1 - 8 5.3 11.1 13 4.7 11.1 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Presenilin PF01080.17 EMD63150.1 - 8.1 5.1 10.3 14 4.3 10.3 1.3 1 0 0 1 1 1 0 Presenilin zf-C2HE PF16278.5 EMD63150.1 - 9.6 6.7 13.3 7.9 7.0 4.6 2.8 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger DUF2722 PF10846.8 EMD63150.1 - 9.7 5.0 30.4 0.5 9.2 23.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) zf-C2HC_2 PF13913.6 EMD63150.1 - 10 6.2 7.4 21 5.1 1.9 2.5 2 0 0 2 2 2 0 zinc-finger of a C2HC-type SH3_1 PF00018.28 EMD63155.1 - 3.7e-24 84.1 0.0 1.3e-11 43.9 0.0 2.8 3 0 0 3 3 3 2 SH3 domain SH3_9 PF14604.6 EMD63155.1 - 4.4e-17 61.7 0.2 2.3e-08 33.8 0.2 2.6 2 0 0 2 2 2 2 Variant SH3 domain SH3_2 PF07653.17 EMD63155.1 - 1.2e-13 50.5 0.0 4.4e-09 35.9 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain PX PF00787.24 EMD63155.1 - 7.3e-11 42.0 0.0 1.7e-10 40.9 0.0 1.6 1 0 0 1 1 1 1 PX domain PB1 PF00564.24 EMD63155.1 - 0.0001 22.2 0.1 0.0002 21.2 0.1 1.4 1 0 0 1 1 1 1 PB1 domain DUF4689 PF15755.5 EMD63155.1 - 0.33 10.5 0.0 0.33 10.5 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4689) SAC3_GANP PF03399.16 EMD63157.1 - 3.8e-26 92.2 4.0 4.4e-24 85.4 2.4 2.8 2 1 0 2 2 2 1 SAC3/GANP family CSN8_PSD8_EIF3K PF10075.9 EMD63157.1 - 0.00054 20.0 0.4 0.0094 15.9 0.0 2.2 2 0 0 2 2 2 1 CSN8/PSMD8/EIF3K family PCI PF01399.27 EMD63157.1 - 0.13 12.8 0.5 0.47 11.0 0.1 2.2 2 1 0 2 2 2 0 PCI domain EAP30 PF04157.16 EMD63158.1 - 5.8e-44 150.1 0.7 7.3e-44 149.8 0.7 1.1 1 0 0 1 1 1 1 EAP30/Vps36 family Vps36-NZF-N PF16988.5 EMD63158.1 - 7.7e-23 79.7 1.8 7.7e-23 79.7 1.8 2.6 2 1 0 2 2 2 1 Vacuolar protein sorting 36 NZF-N zinc-finger domain Vps36_ESCRT-II PF11605.8 EMD63158.1 - 6.5e-22 77.5 0.0 1e-21 76.9 0.0 1.3 1 0 0 1 1 1 1 Vacuolar protein sorting protein 36 Vps36 zf-Sec23_Sec24 PF04810.15 EMD63158.1 - 0.00024 21.1 4.7 0.0037 17.3 0.3 2.4 2 0 0 2 2 2 2 Sec23/Sec24 zinc finger zf-RanBP PF00641.18 EMD63158.1 - 0.0025 17.1 2.1 0.0025 17.1 2.1 2.7 3 0 0 3 3 3 2 Zn-finger in Ran binding protein and others DZR PF12773.7 EMD63158.1 - 0.046 13.8 7.1 0.24 11.5 4.6 2.4 1 1 1 2 2 2 0 Double zinc ribbon OrfB_Zn_ribbon PF07282.11 EMD63158.1 - 0.26 11.3 1.4 17 5.4 0.0 2.5 2 0 0 2 2 2 0 Putative transposase DNA-binding domain Ephrin_rec_like PF07699.13 EMD63158.1 - 1.5 8.6 7.5 0.13 12.0 2.1 2.1 2 0 0 2 2 2 0 Putative ephrin-receptor like F-box-like_2 PF13013.6 EMD63159.1 - 0.0017 18.3 0.1 0.014 15.4 0.1 2.2 1 1 0 1 1 1 1 F-box-like domain Inhibitor_I66 PF16850.5 EMD63160.1 - 1.4e-07 31.5 0.0 2e-07 31.0 0.0 1.2 1 0 0 1 1 1 1 Peptidase inhibitor I66 Trypsin PF00089.26 EMD63161.1 - 6.5e-63 212.5 6.3 7.4e-63 212.3 6.3 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 EMD63161.1 - 1.8e-06 28.9 7.7 3.4e-06 28.0 7.7 1.5 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF2418 PF10332.9 EMD63162.1 - 6.6e-35 119.5 0.1 1.1e-34 118.8 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2418) ATP-synt_F PF01990.17 EMD63163.1 - 9.1e-33 112.5 0.0 1e-32 112.3 0.0 1.0 1 0 0 1 1 1 1 ATP synthase (F/14-kDa) subunit DXP_synthase_N PF13292.6 EMD63163.1 - 0.18 11.0 0.0 0.19 10.9 0.0 1.2 1 0 0 1 1 1 0 1-deoxy-D-xylulose-5-phosphate synthase E1_DerP2_DerF2 PF02221.15 EMD63164.1 - 1e-27 97.2 0.1 1.3e-27 96.9 0.1 1.1 1 0 0 1 1 1 1 ML domain TRP_N PF14558.6 EMD63164.1 - 0.01 16.2 0.0 0.021 15.2 0.0 1.5 1 1 0 1 1 1 0 ML-like domain Big_9 PF17963.1 EMD63164.1 - 0.024 15.4 0.0 0.04 14.7 0.0 1.4 1 0 0 1 1 1 0 Bacterial Ig domain MFS_1 PF07690.16 EMD63165.1 - 4.7e-29 101.4 30.0 6.4e-29 101.0 30.0 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Peptidase_S8 PF00082.22 EMD63166.1 - 2.3e-13 50.1 4.7 8.1e-13 48.3 4.7 1.7 1 1 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 EMD63166.1 - 0.021 15.5 0.0 0.052 14.2 0.0 1.7 1 0 0 1 1 1 0 Peptidase inhibitor I9 WSC PF01822.19 EMD63167.1 - 4e-11 42.9 10.7 4.5e-11 42.8 10.7 1.0 1 0 0 1 1 1 1 WSC domain Sugar_tr PF00083.24 EMD63168.1 - 2.7e-84 283.6 24.6 3.2e-84 283.4 24.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD63168.1 - 4.8e-14 52.1 34.5 4.8e-14 52.1 34.5 2.2 1 1 2 3 3 3 2 Major Facilitator Superfamily Fungal_trans PF04082.18 EMD63169.1 - 5.6e-18 64.9 0.0 8.6e-18 64.3 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD63169.1 - 0.0073 16.4 5.4 0.013 15.6 5.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Melibiase_2 PF16499.5 EMD63170.1 - 4.8e-59 199.9 3.1 5.5e-57 193.1 3.1 2.3 1 1 0 1 1 1 1 Alpha galactosidase A Melibiase_C PF17801.1 EMD63170.1 - 4.5e-10 39.5 0.1 7.5e-09 35.5 0.0 2.6 3 0 0 3 3 3 1 Alpha galactosidase C-terminal beta sandwich domain Melibiase PF02065.18 EMD63170.1 - 4.5e-08 32.4 0.0 7.5e-08 31.7 0.0 1.2 1 0 0 1 1 1 1 Melibiase E1-E2_ATPase PF00122.20 EMD63171.1 - 3.7e-50 170.0 4.2 5.2e-50 169.5 0.0 2.6 2 1 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 EMD63171.1 - 5.2e-38 131.5 0.0 8.4e-38 130.8 0.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HMA PF00403.26 EMD63171.1 - 5.6e-25 87.6 3.4 6e-12 45.8 0.4 3.4 3 0 0 3 3 3 3 Heavy-metal-associated domain HAD PF12710.7 EMD63171.1 - 0.00043 20.7 0.0 0.0012 19.3 0.0 1.8 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EMD63171.1 - 0.00073 19.4 0.0 0.0014 18.4 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase BON PF04972.17 EMD63171.1 - 0.0046 17.2 0.3 0.027 14.8 0.1 2.2 2 0 0 2 2 2 1 BON domain DUF2755 PF10954.8 EMD63171.1 - 0.14 12.1 0.5 0.52 10.3 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2755) RRM_3 PF08777.11 EMD63171.1 - 0.18 11.9 0.0 0.58 10.2 0.0 1.8 1 1 1 2 2 2 0 RNA binding motif SPATA48 PF15073.6 EMD63172.1 - 0.0059 16.9 1.8 0.0059 16.9 1.8 2.3 1 1 1 2 2 2 1 Spermatogenesis-associated protein 48 Coiled-coil_56 PF09813.9 EMD63173.1 - 8.2e-07 29.0 0.0 9e-07 28.9 0.0 1.2 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 56 DUF3453 PF11935.8 EMD63174.1 - 1.3e-66 224.5 0.0 3.6e-66 223.0 0.0 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF3453) tRNA-synt_1 PF00133.22 EMD63175.1 - 1.8e-219 730.0 0.0 4.6e-218 725.3 0.0 2.3 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 EMD63175.1 - 2.6e-32 111.9 0.2 2.6e-32 111.9 0.2 2.5 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 EMD63175.1 - 3.4e-15 55.7 0.7 1.6e-06 27.1 0.1 4.1 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.6 EMD63175.1 - 5.2e-10 39.1 5.5 7.7e-09 35.3 0.0 2.9 2 1 1 3 3 3 2 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1e PF01406.19 EMD63175.1 - 0.018 14.4 2.6 0.54 9.6 0.0 2.9 3 0 0 3 3 3 0 tRNA synthetases class I (C) catalytic domain RES PF08808.11 EMD63175.1 - 0.091 12.6 0.0 0.2 11.5 0.0 1.5 1 0 0 1 1 1 0 RES domain Pkinase PF00069.25 EMD63176.1 - 3e-66 223.5 0.1 3.5e-66 223.3 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD63176.1 - 4.5e-19 68.8 0.0 6.4e-19 68.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EMD63176.1 - 1.3e-07 31.8 0.1 1.8e-05 24.8 0.1 2.6 2 1 1 3 3 3 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EMD63176.1 - 0.0043 15.9 0.0 0.0084 14.9 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EMD63176.1 - 0.0088 15.4 0.0 0.015 14.7 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EMD63176.1 - 0.022 14.1 0.3 0.045 13.1 0.3 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 EMD63176.1 - 0.035 13.7 0.1 0.035 13.7 0.1 2.0 3 0 0 3 3 3 0 Choline/ethanolamine kinase RNase_P_p30 PF01876.16 EMD63177.1 - 5.1e-58 196.1 0.0 7.2e-58 195.6 0.0 1.2 1 0 0 1 1 1 1 RNase P subunit p30 DUF1295 PF06966.12 EMD63179.1 - 4.2e-57 193.4 0.3 5.5e-57 193.0 0.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) Steroid_dh PF02544.16 EMD63179.1 - 1.9e-05 24.7 0.2 1.9e-05 24.7 0.2 3.5 2 1 2 4 4 4 1 3-oxo-5-alpha-steroid 4-dehydrogenase ICMT PF04140.14 EMD63179.1 - 3.3e-05 24.2 1.2 5.1e-05 23.6 0.0 1.9 2 0 0 2 2 2 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 EMD63179.1 - 0.021 15.2 3.8 0.093 13.1 0.1 3.0 2 1 1 3 3 3 0 Phospholipid methyltransferase DUF3602 PF12223.8 EMD63180.1 - 6.7e-22 77.9 15.5 1.7e-20 73.4 7.4 2.4 1 1 1 2 2 2 2 Protein of unknown function (DUF3602) HRCT1 PF15758.5 EMD63180.1 - 0.06 14.3 2.2 0.094 13.7 2.2 1.2 1 0 0 1 1 1 0 Histidine-rich carboxyl terminus protein 1 Aldolase_II PF00596.21 EMD63181.1 - 2.4e-47 161.3 0.0 2.8e-47 161.1 0.0 1.0 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain Sortilin-Vps10 PF15902.5 EMD63182.1 - 1.9e-291 966.3 25.5 2.1e-153 511.3 10.0 2.1 2 0 0 2 2 2 2 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.5 EMD63182.1 - 2.1e-84 282.1 15.3 2.5e-43 148.4 2.2 2.5 2 0 0 2 2 2 2 Sortilin, neurotensin receptor 3, C-terminal BNR PF02012.20 EMD63182.1 - 3.7e-11 41.3 27.6 0.53 10.5 0.1 10.4 10 0 0 10 10 10 6 BNR/Asp-box repeat PSII_BNR PF14870.6 EMD63182.1 - 8.5e-07 28.5 6.8 0.0022 17.3 0.1 5.0 4 1 0 5 5 5 3 Photosynthesis system II assembly factor YCF48 BNR_6 PF15899.5 EMD63182.1 - 0.11 12.6 17.2 0.78 10.0 0.1 6.3 7 0 0 7 7 7 0 BNR-Asp box repeat Peptidase_S8 PF00082.22 EMD63183.1 - 6e-36 124.2 13.7 1.6e-35 122.8 13.7 1.6 1 1 0 1 1 1 1 Subtilase family FAD_binding_2 PF00890.24 EMD63185.1 - 4.2e-128 428.0 3.4 5.3e-128 427.7 3.4 1.1 1 0 0 1 1 1 1 FAD binding domain Succ_DH_flav_C PF02910.20 EMD63185.1 - 3.8e-45 153.0 0.5 5.7e-45 152.4 0.5 1.3 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term GIDA PF01134.22 EMD63185.1 - 1.4e-05 24.4 2.0 0.012 14.7 1.7 2.2 2 0 0 2 2 2 2 Glucose inhibited division protein A Pyr_redox_2 PF07992.14 EMD63185.1 - 5.7e-05 22.5 0.2 0.0019 17.5 0.0 2.5 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EMD63185.1 - 0.00012 21.4 0.1 0.061 12.6 0.1 2.6 3 0 0 3 3 3 2 Thi4 family FAD_binding_3 PF01494.19 EMD63185.1 - 0.0039 16.5 0.1 0.0075 15.5 0.1 1.5 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 EMD63185.1 - 0.064 12.8 2.6 0.38 10.3 2.6 2.0 1 1 0 1 1 1 0 FAD dependent oxidoreductase HI0933_like PF03486.14 EMD63185.1 - 0.077 11.7 0.3 0.25 10.0 0.1 2.0 2 0 0 2 2 2 0 HI0933-like protein DUF2268 PF10026.9 EMD63186.1 - 0.0011 18.6 0.0 0.0022 17.6 0.0 1.5 1 0 0 1 1 1 1 Predicted Zn-dependent protease (DUF2268) Peptidase_M9 PF01752.17 EMD63186.1 - 0.077 12.2 0.2 0.17 11.1 0.2 1.5 1 0 0 1 1 1 0 Collagenase Mucin PF01456.17 EMD63186.1 - 7 6.6 28.5 0.8 9.7 23.3 2.0 2 0 0 2 2 2 0 Mucin-like glycoprotein WD40 PF00400.32 EMD63187.1 - 1e-12 48.3 0.0 1.3e-12 48.0 0.0 1.1 1 0 0 1 1 1 1 WD domain, G-beta repeat Ge1_WD40 PF16529.5 EMD63187.1 - 3e-05 23.1 0.0 3.3e-05 23.0 0.0 1.0 1 0 0 1 1 1 1 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 EMD63187.1 - 8.3e-05 22.8 0.0 8.8e-05 22.7 0.0 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 EMD63187.1 - 0.016 15.1 0.0 0.019 14.9 0.0 1.2 1 0 0 1 1 1 0 WD40-like Beta Propeller Repeat SMP_2 PF10144.9 EMD63187.1 - 0.017 14.7 0.0 0.019 14.6 0.0 1.0 1 0 0 1 1 1 0 Bacterial virulence factor haemolysin DUF3732 PF12532.8 EMD63187.1 - 0.18 11.3 0.0 0.2 11.2 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3732) Pkinase PF00069.25 EMD63188.1 - 2.7e-13 49.9 0.3 3.7e-07 29.8 0.2 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EMD63188.1 - 0.0077 15.5 0.4 0.015 14.6 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EMD63188.1 - 0.018 13.9 0.2 0.025 13.4 0.2 1.2 1 0 0 1 1 1 0 Fungal protein kinase APH PF01636.23 EMD63188.1 - 0.019 14.9 0.0 0.032 14.1 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Ribosomal_L3 PF00297.22 EMD63189.1 - 1.1e-184 613.6 9.1 1.2e-184 613.5 9.1 1.0 1 0 0 1 1 1 1 Ribosomal protein L3 WD40 PF00400.32 EMD63190.1 - 1.2e-12 48.1 4.0 0.12 13.3 0.3 6.5 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD63190.1 - 0.011 16.1 0.1 3.5 8.0 0.0 3.8 4 2 0 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain PMT PF02366.18 EMD63191.1 - 2.5e-82 276.1 16.8 2.5e-82 276.1 16.8 2.2 3 0 0 3 3 3 1 Dolichyl-phosphate-mannose-protein mannosyltransferase UAA PF08449.11 EMD63191.1 - 3.7e-81 272.6 14.5 3.7e-81 272.6 14.5 1.8 2 0 0 2 2 2 1 UAA transporter family PMT_4TMC PF16192.5 EMD63191.1 - 7.6e-72 241.1 2.4 7.6e-72 241.1 2.4 3.7 4 1 0 4 4 4 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 EMD63191.1 - 1.4e-18 67.4 0.8 2.7e-18 66.5 0.8 1.5 1 0 0 1 1 1 1 MIR domain Nuc_sug_transp PF04142.15 EMD63191.1 - 0.00017 20.9 7.9 0.00078 18.7 7.9 1.9 1 1 0 1 1 1 1 Nucleotide-sugar transporter DUF334 PF03904.13 EMD63191.1 - 0.1 12.1 0.2 0.2 11.2 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF334) TPR_1 PF00515.28 EMD63192.1 - 1.7e-21 75.0 3.2 1.4e-07 31.0 0.0 5.9 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_2 PF07719.17 EMD63192.1 - 4.4e-20 70.1 6.2 3.8e-06 26.6 0.1 6.0 6 0 0 6 6 5 5 Tetratricopeptide repeat TPR_11 PF13414.6 EMD63192.1 - 7.7e-16 57.5 4.8 1.1e-07 31.4 0.0 5.1 4 2 1 5 5 5 3 TPR repeat TPR_16 PF13432.6 EMD63192.1 - 1.4e-15 57.6 7.0 1.7e-06 28.5 0.2 4.4 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.6 EMD63192.1 - 1.5e-15 56.6 6.5 2.1e-05 25.0 0.1 5.5 3 1 2 5 5 5 3 Tetratricopeptide repeat TPR_19 PF14559.6 EMD63192.1 - 4.6e-14 52.7 3.9 0.0015 19.0 0.1 4.5 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.6 EMD63192.1 - 2.8e-11 43.0 1.8 0.21 12.0 0.1 4.8 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_8 PF13181.6 EMD63192.1 - 1.2e-10 40.7 0.9 0.0015 18.6 0.0 5.1 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_9 PF13371.6 EMD63192.1 - 1.9e-09 37.6 2.8 0.0016 18.6 0.1 3.7 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 EMD63192.1 - 2.2e-08 34.3 5.5 0.00027 21.2 0.1 4.0 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 EMD63192.1 - 3e-08 33.1 6.5 0.089 12.9 0.0 6.0 8 0 0 8 8 5 2 Tetratricopeptide repeat TPR_20 PF14561.6 EMD63192.1 - 1.1e-07 32.1 8.7 0.002 18.4 0.0 4.7 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_6 PF13174.6 EMD63192.1 - 3.8e-06 27.2 2.5 21 6.0 0.0 6.2 6 0 0 6 6 6 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EMD63192.1 - 1.9e-05 24.8 2.1 0.003 17.7 0.1 2.5 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_15 PF13429.6 EMD63192.1 - 0.0014 18.0 0.7 0.85 8.8 0.6 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_3 PF07720.12 EMD63192.1 - 0.013 15.5 0.0 0.98 9.5 0.0 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_10 PF13374.6 EMD63192.1 - 0.013 15.4 1.9 4.1 7.4 0.6 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat MIT PF04212.18 EMD63192.1 - 0.013 15.6 0.1 38 4.4 0.0 4.6 5 0 0 5 5 5 0 MIT (microtubule interacting and transport) domain NatB_MDM20 PF09797.9 EMD63192.1 - 0.016 14.1 0.0 0.028 13.4 0.0 1.3 1 0 0 1 1 1 0 N-acetyltransferase B complex (NatB) non catalytic subunit DUF4919 PF16266.5 EMD63192.1 - 0.092 12.7 0.0 0.19 11.6 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4919) Adaptin_binding PF10199.9 EMD63192.1 - 1.3 9.7 6.6 3.3 8.3 6.6 1.9 1 1 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 RRM_1 PF00076.22 EMD63193.1 - 9.3e-39 131.1 0.2 3e-23 81.4 0.1 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EMD63193.1 - 5.4e-06 26.0 0.0 0.012 15.2 0.0 2.3 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EMD63193.1 - 0.0012 18.7 0.0 0.0038 17.0 0.0 1.8 2 0 0 2 2 2 1 Occluded RNA-recognition motif RRM_3 PF08777.11 EMD63193.1 - 0.28 11.2 0.9 1 9.5 0.0 2.3 3 0 0 3 3 3 0 RNA binding motif A_deaminase PF00962.22 EMD63194.1 - 1.5e-121 405.8 0.1 2.2e-121 405.2 0.1 1.2 1 0 0 1 1 1 1 Adenosine/AMP deaminase Siva PF05458.12 EMD63195.1 - 0.095 12.4 13.6 0.14 11.8 13.6 1.3 1 0 0 1 1 1 0 Cd27 binding protein (Siva) ELMO_CED12 PF04727.13 EMD63196.1 - 5.4e-50 170.0 0.0 3.2e-49 167.4 0.1 2.0 2 0 0 2 2 2 1 ELMO/CED-12 family PH_12 PF16457.5 EMD63196.1 - 1.9e-39 135.2 0.0 7e-39 133.4 0.0 1.9 2 0 0 2 2 2 1 Pleckstrin homology domain DUF3361 PF11841.8 EMD63196.1 - 6.1e-14 52.2 0.0 1.5e-13 50.9 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3361) DUF3552 PF12072.8 EMD63196.1 - 0.14 11.6 2.4 0.22 10.9 2.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) Spidroin_MaSp PF11260.8 EMD63196.1 - 0.47 10.8 7.5 0.12 12.6 1.8 2.6 3 0 0 3 3 3 0 Major ampullate spidroin 1 and 2 Cpn60_TCP1 PF00118.24 EMD63198.1 - 7.6e-137 456.9 16.2 8.5e-137 456.7 16.2 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family AAA PF00004.29 EMD63199.1 - 3e-40 137.7 0.0 5.3e-40 136.9 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EMD63199.1 - 3.3e-05 23.6 0.0 7.8e-05 22.4 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 EMD63199.1 - 0.00012 22.0 0.1 0.00062 19.8 0.0 2.2 3 1 0 3 3 2 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EMD63199.1 - 0.00013 22.2 0.0 0.0055 17.0 0.0 2.5 1 1 1 2 2 2 1 AAA domain AAA_2 PF07724.14 EMD63199.1 - 0.00035 20.7 0.0 0.0016 18.6 0.0 2.0 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 EMD63199.1 - 0.00058 20.3 0.1 0.011 16.1 0.0 2.3 1 1 1 2 2 2 1 AAA ATPase domain DUF815 PF05673.13 EMD63199.1 - 0.0014 17.8 0.0 0.0026 17.0 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) RuvB_N PF05496.12 EMD63199.1 - 0.009 15.8 0.0 0.018 14.8 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_28 PF13521.6 EMD63199.1 - 0.026 14.8 0.0 0.063 13.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EMD63199.1 - 0.029 13.9 0.0 0.095 12.2 0.0 1.9 1 1 0 1 1 1 0 P-loop containing dynein motor region RNA_helicase PF00910.22 EMD63199.1 - 0.048 14.0 0.0 0.15 12.4 0.0 1.9 1 0 0 1 1 1 0 RNA helicase AAA_33 PF13671.6 EMD63199.1 - 0.051 13.7 0.0 0.095 12.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 EMD63199.1 - 0.062 13.1 0.7 0.54 10.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 EMD63199.1 - 0.082 12.6 0.1 0.59 9.8 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_3 PF07726.11 EMD63199.1 - 0.087 12.7 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 EMD63199.1 - 0.092 12.5 0.0 0.28 10.9 0.0 1.9 1 1 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EMD63199.1 - 0.1 13.1 0.0 0.5 10.9 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.6 EMD63199.1 - 0.11 12.6 0.0 0.25 11.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 EMD63199.1 - 0.15 11.5 0.0 0.36 10.2 0.0 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Lactamase_B_2 PF12706.7 EMD63200.1 - 2.5e-33 115.3 0.0 3.4e-32 111.6 0.0 2.1 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 EMD63200.1 - 1e-10 41.7 0.0 2.1e-10 40.8 0.0 1.6 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Ribonuclease_T2 PF00445.18 EMD63201.1 - 2.6e-33 115.8 0.0 3.6e-33 115.3 0.0 1.2 1 0 0 1 1 1 1 Ribonuclease T2 family RNA_pol_3_Rpc31 PF11705.8 EMD63202.1 - 0.24 11.6 19.8 1.2 9.3 19.8 2.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 RRP7 PF12923.7 EMD63203.1 - 0.97 9.6 4.9 13 6.0 0.1 2.7 2 1 0 2 2 2 0 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain MarB PF13999.6 EMD63204.1 - 0.1 12.5 0.1 0.22 11.4 0.1 1.5 1 0 0 1 1 1 0 MarB protein Bac_luciferase PF00296.20 EMD63205.1 - 4.7e-53 180.7 0.2 6.3e-53 180.2 0.2 1.1 1 0 0 1 1 1 1 Luciferase-like monooxygenase ADH_N PF08240.12 EMD63206.1 - 4.3e-06 26.6 0.0 8.8e-06 25.6 0.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EMD63206.1 - 0.072 13.1 0.0 0.14 12.2 0.0 1.3 1 0 0 1 1 1 0 Zinc-binding dehydrogenase MFS_1 PF07690.16 EMD63207.1 - 1.2e-10 40.9 29.1 1.2e-10 40.9 29.1 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily UNC-93 PF05978.16 EMD63207.1 - 1.2e-06 28.3 4.9 1.2e-06 28.3 4.9 2.6 3 0 0 3 3 3 1 Ion channel regulatory protein UNC-93 FMO-like PF00743.19 EMD63208.1 - 7.3e-16 57.7 0.1 2.4e-15 56.0 0.1 1.7 1 1 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 EMD63208.1 - 4.5e-11 42.5 0.0 1.1e-08 34.7 0.0 2.2 1 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EMD63208.1 - 8.3e-11 42.0 0.0 3.1e-10 40.1 0.0 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 EMD63208.1 - 6.8e-08 32.1 0.5 4e-07 29.6 0.5 2.1 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EMD63208.1 - 5.8e-06 26.1 0.6 0.00072 19.2 0.6 3.2 1 1 0 1 1 1 1 FAD dependent oxidoreductase K_oxygenase PF13434.6 EMD63208.1 - 2.2e-05 23.8 0.5 0.00014 21.1 0.2 2.3 2 1 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 EMD63208.1 - 0.0044 17.0 0.0 1.5 8.8 0.0 3.4 3 1 1 4 4 4 1 FAD-NAD(P)-binding Pyr_redox PF00070.27 EMD63208.1 - 0.014 15.9 0.5 1.3 9.7 0.0 2.9 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EMD63208.1 - 0.017 14.4 0.4 0.031 13.5 0.0 1.6 2 0 0 2 2 2 0 Thi4 family FAD_binding_3 PF01494.19 EMD63208.1 - 0.27 10.4 0.4 0.57 9.4 0.4 1.5 1 0 0 1 1 1 0 FAD binding domain PHO4 PF01384.20 EMD63209.1 - 4.1e-103 345.0 17.3 4.7e-103 344.8 17.3 1.0 1 0 0 1 1 1 1 Phosphate transporter family UPF0444 PF15475.6 EMD63209.1 - 0.47 10.8 9.2 0.46 10.8 0.3 3.0 2 1 0 2 2 2 0 Transmembrane protein C12orf23, UPF0444 CFEM PF05730.11 EMD63210.1 - 2.6e-07 30.6 1.0 7.2e-07 29.2 1.0 1.7 1 0 0 1 1 1 1 CFEM domain Ribul_P_3_epim PF00834.19 EMD63211.1 - 2.5e-62 209.8 0.0 2.2e-61 206.7 0.0 1.9 1 1 0 1 1 1 1 Ribulose-phosphate 3 epimerase family QRPTase_C PF01729.19 EMD63211.1 - 0.023 14.5 0.0 0.04 13.7 0.0 1.3 1 0 0 1 1 1 0 Quinolinate phosphoribosyl transferase, C-terminal domain His_biosynth PF00977.21 EMD63211.1 - 0.033 13.6 0.0 0.37 10.2 0.0 2.4 3 0 0 3 3 3 0 Histidine biosynthesis protein OMPdecase PF00215.24 EMD63211.1 - 0.043 13.4 0.0 0.075 12.6 0.0 1.4 1 0 0 1 1 1 0 Orotidine 5'-phosphate decarboxylase / HUMPS family Methyltransf_11 PF08241.12 EMD63212.1 - 2.4e-06 28.1 0.0 6e-06 26.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMD63212.1 - 0.013 16.2 0.0 0.035 14.8 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain MREG PF15812.5 EMD63212.1 - 0.028 14.7 0.0 0.088 13.1 0.0 1.7 2 0 0 2 2 2 0 Melanoregulin LSM PF01423.22 EMD63213.1 - 6.6e-16 57.8 0.0 9.8e-16 57.2 0.0 1.3 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EMD63213.1 - 0.019 15.1 0.0 0.029 14.5 0.0 1.3 1 1 0 1 1 1 0 Ataxin 2 SM domain Hfq PF17209.3 EMD63213.1 - 0.024 14.3 0.0 0.032 13.9 0.0 1.2 1 0 0 1 1 1 0 Hfq protein FeS_assembly_P PF01883.19 EMD63214.1 - 1.6e-08 34.6 0.0 4.4e-08 33.2 0.0 1.8 1 1 0 1 1 1 1 Iron-sulfur cluster assembly protein Zn_clus PF00172.18 EMD63216.1 - 7e-07 29.3 6.9 1.5e-06 28.2 6.9 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EMD63216.1 - 6.7e-05 22.0 1.5 7.7e-05 21.9 0.3 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zf_RING PF16744.5 EMD63216.1 - 0.93 9.7 3.8 40 4.4 1.3 2.8 3 0 0 3 3 3 0 KIAA1045 RING finger DUF2023 PF09633.10 EMD63217.1 - 0.05 13.7 0.1 0.067 13.3 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2023) Xan_ur_permease PF00860.20 EMD63218.1 - 1.6e-38 132.4 24.8 5.7e-37 127.3 24.8 2.7 1 1 0 1 1 1 1 Permease family MFS_MOT1 PF16983.5 EMD63218.1 - 5.5 7.4 21.3 0.039 14.3 6.5 3.0 3 1 0 3 3 3 0 Molybdate transporter of MFS superfamily Zn_clus PF00172.18 EMD63219.1 - 0.00014 21.9 8.8 0.00035 20.6 8.8 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain 2OG-FeII_Oxy PF03171.20 EMD63220.1 - 4.5e-15 56.0 0.0 8.7e-15 55.1 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 EMD63220.1 - 0.00066 20.4 0.1 0.0096 16.7 0.0 2.5 1 1 1 2 2 2 1 non-haem dioxygenase in morphine synthesis N-terminal Tsc35 PF15079.6 EMD63220.1 - 0.086 12.4 0.2 8.1 6.0 0.0 2.2 2 0 0 2 2 2 0 Testis-specific protein 35 adh_short PF00106.25 EMD63221.1 - 1.8e-15 57.0 0.0 7.9e-11 41.8 0.0 3.0 2 1 0 2 2 2 2 short chain dehydrogenase KR PF08659.10 EMD63221.1 - 0.00017 21.5 0.0 0.00047 20.1 0.0 1.7 2 0 0 2 2 2 1 KR domain adh_short_C2 PF13561.6 EMD63221.1 - 0.0066 16.0 0.0 0.18 11.4 0.0 2.2 1 1 1 2 2 2 1 Enoyl-(Acyl carrier protein) reductase THF_DHG_CYH_C PF02882.19 EMD63221.1 - 0.0076 15.6 0.0 0.014 14.8 0.0 1.3 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain GDP_Man_Dehyd PF16363.5 EMD63221.1 - 0.041 13.3 0.0 0.088 12.2 0.0 1.5 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 EMD63221.1 - 0.13 11.7 0.0 0.23 10.9 0.0 1.6 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family DUF2201 PF09967.9 EMD63221.1 - 0.15 12.2 0.2 0.42 10.8 0.1 1.7 2 0 0 2 2 2 0 VWA-like domain (DUF2201) p450 PF00067.22 EMD63222.1 - 9.3e-11 41.1 0.0 1.1e-10 40.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF4572 PF15139.6 EMD63222.1 - 0.1 12.5 0.1 0.13 12.2 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4572) DUF3176 PF11374.8 EMD63223.1 - 7.4e-35 119.4 0.1 7.4e-35 119.4 0.1 2.5 3 0 0 3 3 3 1 Protein of unknown function (DUF3176) Neurensin PF14927.6 EMD63223.1 - 1.5 8.5 4.3 2 8.1 1.0 2.7 2 1 0 2 2 2 0 Neurensin MFS_1 PF07690.16 EMD63224.1 - 4.1e-28 98.3 23.6 2.2e-14 53.2 6.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EMD63224.1 - 4.9e-09 35.2 15.7 0.00017 20.3 10.0 2.4 2 0 0 2 2 2 2 MFS/sugar transport protein Sugar_tr PF00083.24 EMD63224.1 - 5.6e-09 35.4 16.0 8.6e-06 24.9 6.4 2.5 3 0 0 3 3 3 2 Sugar (and other) transporter OATP PF03137.20 EMD63224.1 - 2.8e-06 25.9 7.0 0.016 13.5 0.2 3.2 2 1 0 3 3 3 3 Organic Anion Transporter Polypeptide (OATP) family MFS_3 PF05977.13 EMD63224.1 - 3.6e-05 22.4 10.2 0.011 14.1 2.2 2.1 2 0 0 2 2 2 2 Transmembrane secretion effector MFS_1_like PF12832.7 EMD63224.1 - 0.0072 15.2 13.1 0.013 14.4 5.5 2.1 1 1 1 2 2 2 2 MFS_1 like family UCR_Fe-S_N PF10399.9 EMD63224.1 - 1.4 8.3 6.8 4.2 6.8 0.1 3.2 3 0 0 3 3 3 0 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal PMM PF03332.13 EMD63226.1 - 0.079 12.7 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Eukaryotic phosphomannomutase DUF3807 PF12720.7 EMD63227.1 - 8.8e-50 169.5 10.0 1e-49 169.3 10.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3807) DUF853 PF05872.12 EMD63227.1 - 0.1 11.2 6.0 0.13 10.8 6.0 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) Hid1 PF12722.7 EMD63227.1 - 5 5.1 6.6 5.6 5.0 6.6 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein CCDC106 PF15794.5 EMD63227.1 - 5 6.8 12.7 6.9 6.3 12.7 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 CDC45 PF02724.14 EMD63227.1 - 9.1 4.4 12.5 11 4.2 12.5 1.1 1 0 0 1 1 1 0 CDC45-like protein Band_3_cyto PF07565.13 EMD63227.1 - 9.7 5.9 7.1 12 5.6 7.1 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Fasciclin PF02469.22 EMD63228.1 - 0.009 16.2 0.0 0.015 15.6 0.0 1.3 1 0 0 1 1 1 1 Fasciclin domain Carb_kinase PF01256.17 EMD63229.1 - 5.6e-58 196.3 0.2 7.6e-58 195.8 0.2 1.2 1 0 0 1 1 1 1 Carbohydrate kinase HK PF02110.15 EMD63229.1 - 0.00099 18.6 0.0 0.0015 17.9 0.0 1.3 1 0 0 1 1 1 1 Hydroxyethylthiazole kinase family Phos_pyr_kin PF08543.12 EMD63229.1 - 0.026 13.9 0.0 0.048 13.0 0.0 1.5 1 1 0 1 1 1 0 Phosphomethylpyrimidine kinase PfkB PF00294.24 EMD63229.1 - 0.05 12.9 0.0 0.081 12.2 0.0 1.4 1 0 0 1 1 1 0 pfkB family carbohydrate kinase PWWP PF00855.17 EMD63230.1 - 5.7e-15 55.5 0.0 5.7e-15 55.5 0.0 3.9 4 0 0 4 4 4 1 PWWP domain CBS PF00571.28 EMD63231.1 - 2e-07 31.3 0.0 0.053 14.0 0.0 3.1 2 1 1 3 3 3 3 CBS domain PP2C_2 PF13672.6 EMD63232.1 - 1.9e-06 27.7 0.1 2.8e-06 27.1 0.1 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C PF00481.21 EMD63232.1 - 6.7e-06 25.9 0.1 0.0075 15.9 0.0 2.1 2 0 0 2 2 2 2 Protein phosphatase 2C SpoIIE PF07228.12 EMD63232.1 - 7.2e-06 26.1 0.0 1.3e-05 25.3 0.0 1.4 1 1 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) Pox_I6 PF04595.13 EMD63232.1 - 0.22 10.4 0.0 0.34 9.8 0.0 1.2 1 0 0 1 1 1 0 Poxvirus I6-like family Vps53_N PF04100.12 EMD63233.1 - 7.5e-107 357.6 4.9 7.5e-107 357.6 4.9 1.6 2 0 0 2 2 2 1 Vps53-like, N-terminal Vps54_N PF10475.9 EMD63233.1 - 1.3e-08 34.5 5.8 2.6e-08 33.5 5.8 1.4 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex DUF2451 PF10474.9 EMD63233.1 - 7.4e-05 22.7 0.0 0.00025 20.9 0.0 1.9 1 0 0 1 1 1 1 Protein of unknown function C-terminus (DUF2451) COG2 PF06148.11 EMD63233.1 - 0.011 15.8 4.9 0.055 13.6 3.6 2.8 1 1 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 Zw10 PF06248.13 EMD63233.1 - 0.017 13.7 8.2 0.0065 15.1 5.6 1.5 2 0 0 2 2 2 0 Centromere/kinetochore Zw10 Baculo_PEP_C PF04513.12 EMD63233.1 - 0.043 13.9 5.2 0.059 13.4 3.0 2.3 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus VPS53_C PF16854.5 EMD63233.1 - 0.055 13.3 0.3 0.38 10.6 0.0 2.3 2 1 1 3 3 3 0 Vacuolar protein sorting-associated protein 53 C-terminus Allexi_40kDa PF05549.11 EMD63233.1 - 0.15 11.5 2.8 0.22 11.0 1.8 1.6 1 1 0 1 1 1 0 Allexivirus 40kDa protein APG6_N PF17675.1 EMD63233.1 - 0.3 11.6 6.2 1 9.9 6.0 2.1 1 1 0 1 1 1 0 Apg6 coiled-coil region FapA PF03961.13 EMD63233.1 - 0.34 9.5 1.0 0.61 8.6 1.0 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A MitMem_reg PF13012.6 EMD63233.1 - 0.45 10.9 3.4 3.1 8.2 0.0 3.0 2 1 0 2 2 2 0 Maintenance of mitochondrial structure and function DUF5339 PF17274.2 EMD63233.1 - 2.7 8.9 6.4 3.5 8.6 0.2 3.1 2 1 1 3 3 2 0 Family of unknown function (DUF5339) Flagellin_N PF00669.20 EMD63233.1 - 3.3 7.8 10.5 1.9 8.6 2.1 2.6 1 1 1 2 2 2 0 Bacterial flagellin N-terminal helical region Plk4_PB2 PF18409.1 EMD63233.1 - 4.7 7.9 7.5 28 5.4 0.4 4.4 3 1 2 5 5 5 0 Polo-like Kinase 4 Polo Box 2 Nop14 PF04147.12 EMD63235.1 - 5.3e-238 792.6 41.9 1.1e-184 616.2 26.8 2.2 1 1 1 2 2 2 2 Nop14-like family Sulfate_transp PF00916.20 EMD63237.1 - 2.1e-107 359.2 21.9 2.6e-107 358.9 21.9 1.1 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 EMD63237.1 - 4.6e-09 35.9 0.0 9.1e-09 35.0 0.0 1.4 1 0 0 1 1 1 1 STAS domain MFS_MOT1 PF16983.5 EMD63237.1 - 0.014 15.7 20.1 0.028 14.8 3.6 3.2 3 0 0 3 3 3 0 Molybdate transporter of MFS superfamily Fun_ATP-synt_8 PF05933.13 EMD63237.1 - 1.8 8.8 6.4 11 6.3 0.8 2.8 2 0 0 2 2 2 0 Fungal ATP synthase protein 8 (A6L) TAP_C PF03943.13 EMD63238.1 - 7.9e-13 47.8 0.0 1.6e-12 46.9 0.0 1.5 1 0 0 1 1 1 1 TAP C-terminal domain UBA_4 PF14555.6 EMD63238.1 - 0.00016 21.4 0.4 0.0018 18.0 0.1 2.3 2 0 0 2 2 2 1 UBA-like domain DUF5320 PF17253.2 EMD63238.1 - 2 9.5 15.3 8.1 7.6 15.4 1.9 1 1 0 1 1 1 0 Family of unknown function (DUF5320) COPIIcoated_ERV PF07970.12 EMD63239.1 - 4.1e-86 288.4 0.0 2.1e-85 286.0 0.1 1.9 2 0 0 2 2 2 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 EMD63239.1 - 2.8e-31 107.7 0.0 1e-29 102.7 0.0 2.3 2 0 0 2 2 2 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) DUF3818 PF12825.7 EMD63240.1 - 2.8e-135 450.7 1.8 4.6e-135 450.0 1.8 1.4 1 0 0 1 1 1 1 Domain of unknown function in PX-proteins (DUF3818) PXB PF12828.7 EMD63240.1 - 2.9e-40 137.3 0.7 7e-40 136.0 0.7 1.7 1 0 0 1 1 1 1 PX-associated PX PF00787.24 EMD63240.1 - 3e-10 40.1 0.0 1.3e-09 38.0 0.0 2.1 1 1 0 1 1 1 1 PX domain DUF3546 PF12066.8 EMD63241.1 - 8.9e-30 103.1 10.4 8.9e-30 103.1 10.4 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF3546) ARS2 PF04959.13 EMD63241.1 - 1.4e-14 54.9 2.6 1.5e-14 54.8 0.2 2.2 1 1 1 2 2 2 1 Arsenite-resistance protein 2 DUF4187 PF13821.6 EMD63241.1 - 1.8e-11 43.7 0.9 4.5e-11 42.4 0.2 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4187) TspO_MBR PF03073.15 EMD63242.1 - 3.7e-43 146.8 9.6 5.1e-43 146.4 9.6 1.1 1 0 0 1 1 1 1 TspO/MBR family DUF5353 PF17304.2 EMD63242.1 - 0.016 15.0 0.5 0.13 12.1 0.5 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5353) ERAP1_C PF11838.8 EMD63244.1 - 0.07 12.7 0.0 0.22 11.0 0.0 1.7 2 0 0 2 2 2 0 ERAP1-like C-terminal domain Pkinase PF00069.25 EMD63246.1 - 8.7e-46 156.4 0.0 1.3e-45 155.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD63246.1 - 2.3e-23 82.8 0.0 3.6e-23 82.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EMD63246.1 - 2.2e-05 24.5 0.1 0.23 11.4 0.1 2.6 1 1 1 2 2 2 2 Phosphotransferase enzyme family RIO1 PF01163.22 EMD63246.1 - 0.0036 16.9 0.2 0.011 15.4 0.2 1.8 1 1 0 1 1 1 1 RIO1 family Kdo PF06293.14 EMD63246.1 - 0.13 11.6 0.0 0.22 10.9 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family SpoIIE PF07228.12 EMD63247.1 - 4.5e-08 33.2 0.2 1.2e-07 31.8 0.4 1.7 2 1 0 2 2 2 1 Stage II sporulation protein E (SpoIIE) PP2C PF00481.21 EMD63247.1 - 3.5e-07 30.1 0.0 0.0022 17.7 0.0 2.4 2 0 0 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.6 EMD63247.1 - 3.9e-06 26.6 0.9 7.8e-06 25.7 0.6 1.7 1 1 0 1 1 1 1 Protein phosphatase 2C NAD-GH PF10712.9 EMD63247.1 - 0.014 13.9 0.1 0.024 13.1 0.1 1.3 1 0 0 1 1 1 0 NAD-specific glutamate dehydrogenase SPATA48 PF15073.6 EMD63247.1 - 0.043 14.1 0.2 0.55 10.5 0.1 2.3 2 0 0 2 2 2 0 Spermatogenesis-associated protein 48 WD40 PF00400.32 EMD63248.1 - 6.9e-31 105.8 17.1 7.1e-09 36.2 0.1 7.4 7 1 0 7 7 7 5 WD domain, G-beta repeat PRP4 PF08799.11 EMD63248.1 - 1.9e-14 52.9 4.1 3.6e-14 52.0 2.7 2.2 2 0 0 2 2 2 1 pre-mRNA processing factor 4 (PRP4) like ANAPC4_WD40 PF12894.7 EMD63248.1 - 5.2e-14 52.3 0.0 0.017 15.4 0.0 4.5 2 1 2 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EMD63248.1 - 1.6e-05 24.9 0.0 1.1 9.1 0.0 3.5 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 EMD63248.1 - 0.00056 19.3 0.0 0.63 9.3 0.0 3.4 4 0 0 4 4 4 2 WD40-like domain Nbas_N PF15492.6 EMD63248.1 - 0.063 12.6 0.0 0.54 9.5 0.0 2.3 2 1 1 3 3 3 0 Neuroblastoma-amplified sequence, N terminal Nup160 PF11715.8 EMD63248.1 - 0.23 10.0 1.2 3.7 6.1 0.2 3.0 1 1 2 3 3 3 0 Nucleoporin Nup120/160 bZIP_Maf PF03131.17 EMD63251.1 - 3.3e-10 40.4 8.4 9.6e-10 38.9 6.9 2.5 2 0 0 2 2 2 1 bZIP Maf transcription factor bZIP_1 PF00170.21 EMD63251.1 - 3.3e-07 30.3 9.2 3.3e-07 30.3 9.2 2.2 2 0 0 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.15 EMD63251.1 - 1.2e-06 28.5 10.3 1.2e-06 28.5 10.3 2.1 2 0 0 2 2 2 1 Basic region leucine zipper UPF0242 PF06785.11 EMD63251.1 - 0.19 11.8 16.9 0.22 11.6 15.6 1.6 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus COPIIcoated_ERV PF07970.12 EMD63251.1 - 0.21 11.4 1.3 0.68 9.7 0.8 1.9 2 0 0 2 2 2 0 Endoplasmic reticulum vesicle transporter OmpH PF03938.14 EMD63251.1 - 7.5 6.9 9.8 3.9 7.8 7.6 1.6 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) Sel1 PF08238.12 EMD63252.1 - 1.2e-17 63.9 6.2 3.5e-07 30.7 0.3 3.4 3 0 0 3 3 3 3 Sel1 repeat TPR_6 PF13174.6 EMD63252.1 - 0.0036 17.8 2.2 0.24 12.1 0.1 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat zf-CCCH_3 PF15663.5 EMD63253.1 - 2.3e-05 24.5 2.9 2.3e-05 24.5 2.9 3.7 1 1 3 4 4 4 1 Zinc-finger containing family zf-CCCH PF00642.24 EMD63253.1 - 2.4e-05 24.1 35.3 0.00028 20.7 2.7 5.5 5 0 0 5 5 5 4 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 EMD63253.1 - 0.00033 20.4 31.4 0.00035 20.3 1.5 5.7 5 2 0 5 5 5 3 CCCH-type zinc finger zf_CCCH_4 PF18345.1 EMD63253.1 - 0.00061 19.8 1.8 0.00061 19.8 1.8 6.3 6 1 0 6 6 6 3 Zinc finger domain TPX2 PF06886.11 EMD63253.1 - 0.058 13.6 2.5 0.12 12.6 2.5 1.5 1 0 0 1 1 1 0 Targeting protein for Xklp2 (TPX2) zf-CCCH_2 PF14608.6 EMD63253.1 - 0.38 11.3 30.3 0.57 10.7 3.0 5.4 5 0 0 5 5 5 0 RNA-binding, Nab2-type zinc finger Torus PF16131.5 EMD63253.1 - 0.94 10.2 28.4 7 7.4 0.2 5.5 1 1 4 5 5 5 0 Torus domain TAFII55_N PF04658.13 EMD63254.1 - 4.2e-44 150.1 0.0 4.2e-44 150.1 0.0 2.0 3 0 0 3 3 3 1 TAFII55 protein conserved region Pap_E4 PF02711.14 EMD63254.1 - 0.057 14.4 4.2 0.51 11.3 0.1 3.3 2 0 0 2 2 2 0 E4 protein NOA36 PF06524.12 EMD63254.1 - 4.4 6.5 16.8 4.8 6.4 7.8 2.3 2 0 0 2 2 2 0 NOA36 protein Bromo_TP PF07524.13 EMD63255.1 - 2.5e-07 30.6 0.1 8e-07 29.0 0.0 2.0 3 0 0 3 3 3 1 Bromodomain associated TFIID-31kDa PF02291.15 EMD63255.1 - 0.017 15.2 0.0 0.029 14.5 0.0 1.3 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit Phage_int_SAM_4 PF13495.6 EMD63255.1 - 0.074 13.5 0.3 0.4 11.2 0.0 2.2 2 1 0 2 2 2 0 Phage integrase, N-terminal SAM-like domain FdhD-NarQ PF02634.15 EMD63256.1 - 0.0085 15.8 0.0 0.013 15.2 0.0 1.3 1 0 0 1 1 1 1 FdhD/NarQ family zf-BED PF02892.15 EMD63257.1 - 2.7e-06 27.3 2.5 0.028 14.4 0.0 2.5 2 0 0 2 2 2 2 BED zinc finger WEMBL PF05701.11 EMD63257.1 - 0.66 8.6 4.2 0.92 8.1 4.2 1.1 1 0 0 1 1 1 0 Weak chloroplast movement under blue light DZR PF12773.7 EMD63259.1 - 0.13 12.3 0.8 0.29 11.2 0.8 1.5 1 0 0 1 1 1 0 Double zinc ribbon RecR PF02132.15 EMD63259.1 - 0.3 10.7 2.4 0.7 9.5 2.4 1.6 1 0 0 1 1 1 0 RecR protein Zn_ribbon_SprT PF17283.2 EMD63259.1 - 0.34 10.9 2.3 0.24 11.3 0.4 1.7 2 0 0 2 2 2 0 SprT-like zinc ribbon domain DPPIV_N PF00930.21 EMD63260.1 - 4.8e-111 370.9 0.5 6.4e-111 370.5 0.5 1.2 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.21 EMD63260.1 - 2.9e-56 190.3 1.0 5.6e-56 189.4 1.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S15 PF02129.18 EMD63260.1 - 5e-09 36.1 0.2 1.1e-07 31.8 0.1 2.2 1 1 1 2 2 2 2 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_6 PF12697.7 EMD63260.1 - 0.0018 18.9 0.2 0.26 11.9 0.1 2.4 1 1 1 2 2 2 2 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EMD63260.1 - 0.014 15.0 0.1 0.061 12.9 0.1 1.9 1 1 1 2 2 2 0 alpha/beta hydrolase fold SHS2_Rpb7-N PF03876.17 EMD63261.1 - 4.6e-13 49.3 0.0 7e-13 48.8 0.0 1.3 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 PF00575.23 EMD63261.1 - 1.1e-09 38.5 0.0 1.9e-09 37.7 0.0 1.3 1 0 0 1 1 1 1 S1 RNA binding domain RNA_pol_Rbc25 PF08292.12 EMD63261.1 - 0.00061 20.0 0.0 0.00091 19.5 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase III subunit Rpc25 DUF962 PF06127.11 EMD63262.1 - 5.9e-25 87.2 1.2 8.5e-25 86.7 1.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF962) ATP-synt_ab PF00006.25 EMD63263.1 - 7.6e-74 247.9 0.0 1.1e-73 247.4 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.27 EMD63263.1 - 6.8e-48 162.1 0.9 1.2e-47 161.4 0.9 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.23 EMD63263.1 - 7.1e-16 58.5 2.6 2e-15 57.0 2.6 1.9 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain SNARE_assoc PF09335.11 EMD63264.1 - 3.6e-15 56.5 6.2 3.6e-15 56.5 6.2 2.5 2 1 1 3 3 3 1 SNARE associated Golgi protein DUF4134 PF13572.6 EMD63264.1 - 0.012 15.8 0.4 2.3 8.6 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4134) DUF4212 PF13937.6 EMD63264.1 - 0.39 11.1 3.2 1.2 9.6 3.2 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4212) DUF1771 PF08590.10 EMD63265.1 - 3.5e-15 56.1 8.5 3.5e-15 56.1 8.5 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF1771) zf-CCCH PF00642.24 EMD63265.1 - 4.4e-08 32.8 6.3 0.0012 18.7 1.5 2.5 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EMD63265.1 - 1.9e-07 30.9 11.3 8.8e-06 25.6 1.4 2.9 2 1 0 2 2 2 2 Zinc finger domain zf-CCCH_4 PF18044.1 EMD63265.1 - 1.9e-05 24.3 10.9 0.00021 21.0 0.4 2.9 2 1 0 2 2 2 2 CCCH-type zinc finger Smr PF01713.21 EMD63265.1 - 2.1e-05 24.8 0.0 6.7e-05 23.2 0.0 1.9 1 0 0 1 1 1 1 Smr domain zf-CCCH_2 PF14608.6 EMD63265.1 - 9.5e-05 22.7 11.8 0.0035 17.8 0.9 2.4 2 0 0 2 2 2 2 RNA-binding, Nab2-type zinc finger zf-CCCH_3 PF15663.5 EMD63265.1 - 0.0034 17.6 2.8 0.28 11.4 0.1 2.4 1 1 1 2 2 2 2 Zinc-finger containing family Torus PF16131.5 EMD63265.1 - 1.6 9.5 11.1 0.32 11.7 0.5 2.7 2 1 1 3 3 3 0 Torus domain zf-C3H1 PF10650.9 EMD63265.1 - 9.1 6.1 5.8 30 4.4 0.8 2.4 2 0 0 2 2 2 0 Putative zinc-finger domain DUF1465 PF07323.12 EMD63266.1 - 0.031 14.1 2.4 0.18 11.6 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1465) BLOC1_2 PF10046.9 EMD63266.1 - 0.09 13.1 1.1 0.99 9.8 0.0 2.4 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF1192 PF06698.11 EMD63266.1 - 0.16 12.1 0.2 0.16 12.1 0.2 3.4 3 1 0 3 3 3 0 Protein of unknown function (DUF1192) SOG2 PF10428.9 EMD63266.1 - 0.33 10.1 14.7 0.53 9.4 14.7 1.4 1 0 0 1 1 1 0 RAM signalling pathway protein Exonuc_VII_L PF02601.15 EMD63266.1 - 0.4 10.2 4.1 0.088 12.4 0.4 1.6 2 0 0 2 2 2 0 Exonuclease VII, large subunit DUF4164 PF13747.6 EMD63266.1 - 0.46 10.8 4.4 0.3 11.4 0.2 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4164) DUF465 PF04325.13 EMD63266.1 - 1.1 9.3 3.4 5.2 7.2 0.3 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF465) ZapB PF06005.12 EMD63266.1 - 1.2 9.6 6.4 21 5.7 0.0 3.8 1 1 3 4 4 4 0 Cell division protein ZapB FAA_hydrolase PF01557.18 EMD63267.1 - 2.4e-52 177.7 0.0 2.9e-52 177.5 0.0 1.0 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family DUF2599 PF10783.9 EMD63268.1 - 0.077 13.6 0.0 0.1 13.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2599) PWI PF01480.17 EMD63269.1 - 1e-29 102.6 0.2 1.7e-29 101.9 0.2 1.4 1 0 0 1 1 1 1 PWI domain AAA_18 PF13238.6 EMD63269.1 - 0.11 13.0 0.1 2.9 8.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain tRNA-synt_1g PF09334.11 EMD63269.1 - 0.18 10.5 0.0 0.26 10.0 0.0 1.1 1 0 0 1 1 1 0 tRNA synthetases class I (M) NAD_binding_8 PF13450.6 EMD63271.1 - 2.6e-12 46.8 0.0 5.6e-12 45.7 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 EMD63271.1 - 1.9e-06 27.5 0.0 2.8e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EMD63271.1 - 3e-06 26.6 0.1 4.3e-06 26.1 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain Amino_oxidase PF01593.24 EMD63271.1 - 5.2e-06 26.0 0.0 1.9e-05 24.2 0.0 1.8 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase DAO PF01266.24 EMD63271.1 - 5.1e-05 23.0 0.4 0.00011 21.9 0.3 1.5 2 0 0 2 2 2 1 FAD dependent oxidoreductase HI0933_like PF03486.14 EMD63271.1 - 0.00017 20.4 0.1 0.00026 19.8 0.1 1.2 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_2 PF07992.14 EMD63271.1 - 0.00092 18.5 0.0 0.002 17.5 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EMD63271.1 - 0.0015 19.1 0.2 0.007 16.9 0.1 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EMD63271.1 - 0.011 15.0 0.1 0.019 14.2 0.1 1.3 1 0 0 1 1 1 0 Thi4 family Pyr_redox_3 PF13738.6 EMD63271.1 - 0.036 13.3 0.0 0.087 12.1 0.0 1.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase GMC_oxred_N PF00732.19 EMD63271.1 - 0.041 13.2 0.0 0.066 12.6 0.0 1.3 1 0 0 1 1 1 0 GMC oxidoreductase Trp_halogenase PF04820.14 EMD63271.1 - 0.058 12.2 0.0 0.085 11.7 0.0 1.2 1 0 0 1 1 1 0 Tryptophan halogenase Lycopene_cycl PF05834.12 EMD63271.1 - 0.066 12.2 0.0 0.097 11.7 0.0 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein NAD_binding_9 PF13454.6 EMD63271.1 - 0.09 12.8 0.0 0.24 11.4 0.0 1.7 1 0 0 1 1 1 0 FAD-NAD(P)-binding IF-2B PF01008.17 EMD63271.1 - 0.16 11.1 0.0 0.27 10.4 0.0 1.3 1 0 0 1 1 1 0 Initiation factor 2 subunit family HSP70 PF00012.20 EMD63272.1 - 4.4e-226 751.7 13.1 5e-226 751.6 13.1 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EMD63272.1 - 2.7e-17 62.6 0.5 2.1e-16 59.7 0.2 2.0 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.16 EMD63272.1 - 0.00012 21.8 0.0 0.00029 20.6 0.0 1.6 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain UQ_con PF00179.26 EMD63273.1 - 2.1e-27 95.5 0.1 2.6e-27 95.2 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EMD63273.1 - 7.4e-08 32.2 0.0 2.2e-07 30.6 0.0 1.6 1 1 1 2 2 2 1 Prokaryotic E2 family B UEV PF05743.13 EMD63273.1 - 0.012 15.5 0.1 0.013 15.3 0.1 1.2 1 0 0 1 1 1 0 UEV domain RWD PF05773.22 EMD63273.1 - 0.033 14.5 0.0 0.043 14.1 0.0 1.3 1 0 0 1 1 1 0 RWD domain Peroxin-13_N PF04088.13 EMD63274.1 - 1.4e-50 171.4 0.3 2.3e-50 170.7 0.3 1.4 1 0 0 1 1 1 1 Peroxin 13, N-terminal region SH3_1 PF00018.28 EMD63274.1 - 5.6e-11 41.9 0.0 9.5e-11 41.1 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 EMD63274.1 - 3.9e-08 32.9 0.0 7.2e-08 32.0 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 EMD63274.1 - 3.7e-06 26.7 0.0 6.9e-06 25.8 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain Pex2_Pex12 PF04757.14 EMD63274.1 - 0.069 12.7 0.0 0.1 12.2 0.0 1.2 1 0 0 1 1 1 0 Pex2 / Pex12 amino terminal region hSH3 PF14603.6 EMD63274.1 - 0.18 12.2 0.0 0.33 11.4 0.0 1.3 1 0 0 1 1 1 0 Helically-extended SH3 domain DEC-1_N PF04625.13 EMD63274.1 - 2.5 7.0 7.9 0.038 13.0 0.8 1.6 2 0 0 2 2 2 0 DEC-1 protein, N-terminal region CorA PF01544.18 EMD63275.1 - 0.16 11.3 4.8 0.3 10.3 4.8 1.5 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein Pkinase PF00069.25 EMD63276.1 - 8.4e-22 77.8 0.0 6.1e-20 71.7 0.0 2.6 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EMD63276.1 - 5.8e-19 68.4 0.0 9.1e-17 61.2 0.0 2.8 2 1 0 2 2 2 2 Protein tyrosine kinase TPR_12 PF13424.6 EMD63277.1 - 6.4e-82 269.9 24.5 2.3e-14 53.4 0.0 10.1 5 2 4 10 10 10 10 Tetratricopeptide repeat TPR_10 PF13374.6 EMD63277.1 - 2e-79 259.6 11.2 3.9e-08 32.9 0.0 15.5 16 0 0 16 16 15 14 Tetratricopeptide repeat TPR_7 PF13176.6 EMD63277.1 - 1.2e-24 84.5 20.6 0.0018 18.2 0.0 12.4 12 0 0 12 12 12 6 Tetratricopeptide repeat TPR_2 PF07719.17 EMD63277.1 - 1.8e-23 80.7 20.7 0.11 12.7 0.1 12.5 13 0 0 13 13 12 6 Tetratricopeptide repeat TPR_MalT PF17874.1 EMD63277.1 - 1.1e-22 80.9 26.0 8.9e-10 38.4 3.9 5.2 3 1 2 5 5 5 4 MalT-like TPR region TPR_1 PF00515.28 EMD63277.1 - 2e-22 78.0 17.8 0.038 13.8 0.0 11.7 12 0 0 12 12 12 5 Tetratricopeptide repeat TPR_4 PF07721.14 EMD63277.1 - 3.9e-19 67.3 7.0 0.096 13.4 0.0 10.0 11 0 0 11 11 9 4 Tetratricopeptide repeat TPR_19 PF14559.6 EMD63277.1 - 3.2e-18 66.0 25.1 0.0057 17.1 1.1 9.0 7 3 2 10 10 9 5 Tetratricopeptide repeat TPR_8 PF13181.6 EMD63277.1 - 2e-16 58.7 18.0 0.031 14.5 0.0 10.1 10 0 0 10 10 9 3 Tetratricopeptide repeat TPR_16 PF13432.6 EMD63277.1 - 3.3e-16 59.6 8.5 1.3 9.8 1.5 9.6 8 2 1 9 9 9 5 Tetratricopeptide repeat TPR_14 PF13428.6 EMD63277.1 - 9.5e-11 41.6 31.4 0.4 11.6 0.2 12.9 13 3 2 15 15 14 3 Tetratricopeptide repeat TPR_17 PF13431.6 EMD63277.1 - 1e-10 41.2 11.2 0.51 10.8 0.0 9.1 10 0 0 10 10 9 3 Tetratricopeptide repeat RPN7 PF10602.9 EMD63277.1 - 8.9e-06 25.5 5.8 4.6 6.9 0.0 5.8 4 1 1 5 5 5 2 26S proteasome subunit RPN7 PPR PF01535.20 EMD63277.1 - 0.00046 20.3 9.0 10 6.6 0.0 8.7 11 0 0 11 11 9 0 PPR repeat TPR_20 PF14561.6 EMD63277.1 - 0.00087 19.6 9.7 3.5 8.0 0.5 6.4 5 2 0 5 5 5 1 Tetratricopeptide repeat TPR_9 PF13371.6 EMD63277.1 - 0.0023 18.1 5.6 13 6.0 0.0 6.1 5 2 1 6 6 6 0 Tetratricopeptide repeat TPR_3 PF07720.12 EMD63277.1 - 0.0025 17.8 0.2 9.1 6.4 0.1 4.7 5 0 0 5 5 5 0 Tetratricopeptide repeat DUF2777 PF10949.8 EMD63277.1 - 0.0036 17.0 1.0 13 5.4 0.0 3.8 3 1 0 4 4 4 0 Protein of unknown function (DUF2777) RPN6_N PF18055.1 EMD63277.1 - 0.038 14.3 7.4 0.63 10.4 0.2 4.7 5 0 0 5 5 4 0 26S proteasome regulatory subunit RPN6 N-terminal domain TPR_11 PF13414.6 EMD63277.1 - 0.067 12.9 4.5 98 2.8 0.1 6.3 7 0 0 7 7 7 0 TPR repeat Ribosomal_S11 PF00411.19 EMD63277.1 - 0.079 13.4 0.0 0.2 12.1 0.0 1.6 1 0 0 1 1 1 0 Ribosomal protein S11 DUF1897 PF09005.10 EMD63277.1 - 0.18 11.3 4.6 43 3.7 0.3 5.0 5 0 0 5 5 5 0 Domain of unknown function (DUF1897) TPR_6 PF13174.6 EMD63277.1 - 0.79 10.5 14.1 43 5.0 0.2 8.1 9 0 0 9 9 9 0 Tetratricopeptide repeat TPR_5 PF12688.7 EMD63277.1 - 1.3 9.3 11.0 0.38 11.0 0.2 4.1 4 1 0 4 4 4 0 Tetratrico peptide repeat Acetyltransf_1 PF00583.25 EMD63278.1 - 0.00027 21.2 0.0 0.00064 19.9 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EMD63278.1 - 0.00046 20.6 0.0 0.00084 19.7 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EMD63278.1 - 0.0015 18.6 0.0 0.0047 17.0 0.0 1.9 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EMD63278.1 - 0.0098 15.8 0.0 0.02 14.8 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EMD63278.1 - 0.031 14.3 0.0 0.067 13.2 0.0 1.6 1 0 0 1 1 1 0 FR47-like protein Acetyltransf_13 PF13880.6 EMD63278.1 - 0.14 12.1 0.0 0.33 11.0 0.0 1.6 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase Ribosomal_S13_N PF08069.12 EMD63279.1 - 8.5e-29 99.4 0.0 1.4e-28 98.7 0.0 1.4 1 0 0 1 1 1 1 Ribosomal S13/S15 N-terminal domain Ribosomal_S15 PF00312.22 EMD63279.1 - 3.3e-14 52.8 0.1 4.9e-14 52.3 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein S15 PAX PF00292.18 EMD63279.1 - 0.018 14.9 0.1 0.038 13.9 0.0 1.5 2 0 0 2 2 2 0 'Paired box' domain HOIP-UBA PF16678.5 EMD63279.1 - 0.11 12.5 0.0 0.23 11.4 0.0 1.5 1 1 0 1 1 1 0 HOIP UBA domain pair Dpy-30 PF05186.13 EMD63280.1 - 6.1e-12 45.0 0.2 1e-11 44.3 0.2 1.4 1 0 0 1 1 1 1 Dpy-30 motif Rib_recp_KP_reg PF05104.12 EMD63280.1 - 8.1 7.5 20.1 11 7.1 20.1 1.4 1 0 0 1 1 1 0 Ribosome receptor lysine/proline rich region Rad17 PF03215.15 EMD63284.1 - 4.4e-29 101.7 0.0 8.6e-29 100.8 0.0 1.4 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_30 PF13604.6 EMD63284.1 - 0.00053 19.8 0.1 0.0016 18.2 0.1 1.8 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EMD63284.1 - 0.0013 19.0 0.0 0.0031 17.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EMD63284.1 - 0.0025 18.2 0.0 0.0068 16.8 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain T2SSE PF00437.20 EMD63284.1 - 0.011 14.8 0.0 0.02 14.0 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA PF00004.29 EMD63284.1 - 0.015 15.7 0.0 0.036 14.5 0.0 1.7 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.6 EMD63284.1 - 0.025 14.9 0.0 0.059 13.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain RuvB_N PF05496.12 EMD63284.1 - 0.029 14.1 0.0 0.056 13.2 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain TsaE PF02367.17 EMD63284.1 - 0.048 13.7 0.1 0.094 12.7 0.1 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ResIII PF04851.15 EMD63284.1 - 0.085 12.9 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit ABC_tran PF00005.27 EMD63284.1 - 0.11 13.0 0.0 0.23 12.0 0.0 1.6 1 0 0 1 1 1 0 ABC transporter NACHT PF05729.12 EMD63284.1 - 0.16 11.9 0.0 0.44 10.4 0.0 1.7 1 0 0 1 1 1 0 NACHT domain AAA_7 PF12775.7 EMD63284.1 - 0.16 11.4 0.0 0.3 10.6 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_18 PF13238.6 EMD63284.1 - 0.19 12.3 0.0 0.42 11.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain Glyco_hydro_cc PF11790.8 EMD63286.1 - 2.3e-60 204.2 1.5 2.5e-60 204.0 1.5 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core DUF3844 PF12955.7 EMD63289.1 - 8.2e-35 119.1 3.8 1.3e-34 118.5 3.8 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3844) DUF4665 PF15679.5 EMD63289.1 - 0.12 13.0 0.1 0.27 11.9 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4665) EGF_3 PF12947.7 EMD63289.1 - 1.9 8.8 9.6 3.6 7.9 9.6 1.4 1 0 0 1 1 1 0 EGF domain Sec66 PF09802.9 EMD63290.1 - 2.2e-80 268.5 0.9 2.6e-80 268.3 0.9 1.0 1 0 0 1 1 1 1 Preprotein translocase subunit Sec66 DUF3848 PF12959.7 EMD63290.1 - 0.0024 17.9 0.2 0.006 16.6 0.1 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF3848) PEP-utilisers_N PF05524.13 EMD63290.1 - 0.027 14.6 2.1 0.039 14.1 1.4 1.5 1 1 0 1 1 1 0 PEP-utilising enzyme, N-terminal Sec8_exocyst PF04048.14 EMD63290.1 - 0.028 14.3 0.0 0.042 13.7 0.0 1.4 1 0 0 1 1 1 0 Sec8 exocyst complex component specific domain FUSC PF04632.12 EMD63290.1 - 0.096 11.2 3.3 0.13 10.8 3.3 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family TBCC_N PF16752.5 EMD63290.1 - 0.16 12.4 2.1 0.41 11.1 1.0 2.1 1 1 1 2 2 2 0 Tubulin-specific chaperone C N-terminal domain NPL4 PF05021.15 EMD63291.1 - 1.4e-135 451.6 0.0 1.8e-135 451.2 0.0 1.1 1 0 0 1 1 1 1 NPL4 family zf-NPL4 PF05020.15 EMD63291.1 - 2.4e-67 225.6 0.0 3.6e-67 225.0 0.0 1.3 1 0 0 1 1 1 1 NPL4 family, putative zinc binding region UN_NPL4 PF11543.8 EMD63291.1 - 0.076 13.5 0.0 0.16 12.5 0.0 1.6 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 AAA PF00004.29 EMD63292.1 - 9.5e-15 55.2 0.0 3.7e-14 53.3 0.0 2.0 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rep_fac_C PF08542.11 EMD63292.1 - 4.2e-14 52.7 0.0 8.2e-14 51.8 0.0 1.5 1 0 0 1 1 1 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.6 EMD63292.1 - 1e-12 48.2 0.0 2.2e-07 30.8 0.0 2.5 2 0 0 2 2 2 2 DNA polymerase III, delta subunit Rad17 PF03215.15 EMD63292.1 - 1e-08 35.4 0.0 2e-08 34.4 0.0 1.6 1 1 0 1 1 1 1 Rad17 P-loop domain AAA_22 PF13401.6 EMD63292.1 - 9.8e-06 25.9 0.0 3.1e-05 24.2 0.0 1.7 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.12 EMD63292.1 - 1e-05 25.4 0.0 3.4e-05 23.7 0.0 1.9 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EMD63292.1 - 2.2e-05 24.9 0.0 0.00056 20.3 0.0 2.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_11 PF13086.6 EMD63292.1 - 4e-05 23.5 0.0 8e-05 22.6 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_assoc_2 PF16193.5 EMD63292.1 - 0.00011 22.5 0.1 0.00041 20.6 0.1 2.1 1 0 0 1 1 1 1 AAA C-terminal domain AAA_19 PF13245.6 EMD63292.1 - 0.00021 21.6 0.0 0.00042 20.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain DUF815 PF05673.13 EMD63292.1 - 0.00054 19.2 0.0 0.0048 16.1 0.0 2.0 1 1 1 2 2 2 1 Protein of unknown function (DUF815) DUF2075 PF09848.9 EMD63292.1 - 0.0012 18.2 0.0 0.002 17.5 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) Mg_chelatase PF01078.21 EMD63292.1 - 0.0012 18.2 0.0 0.0075 15.7 0.0 2.2 1 1 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_24 PF13479.6 EMD63292.1 - 0.0028 17.4 0.0 0.0061 16.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 EMD63292.1 - 0.0037 16.8 0.0 0.007 15.9 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_5 PF07728.14 EMD63292.1 - 0.0081 16.2 0.1 0.064 13.2 0.1 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_30 PF13604.6 EMD63292.1 - 0.02 14.6 0.1 0.085 12.6 0.0 2.1 2 1 0 2 2 2 0 AAA domain AAA_18 PF13238.6 EMD63292.1 - 0.025 15.1 0.0 0.11 13.1 0.0 2.2 1 1 0 1 1 1 0 AAA domain AAA_14 PF13173.6 EMD63292.1 - 0.032 14.3 0.0 0.16 12.0 0.0 2.0 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.6 EMD63292.1 - 0.037 14.3 0.0 0.081 13.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain ResIII PF04851.15 EMD63292.1 - 0.059 13.4 0.0 0.16 12.0 0.0 1.6 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit TIP49 PF06068.13 EMD63292.1 - 0.068 12.4 0.0 0.57 9.3 0.0 2.1 2 0 0 2 2 2 0 TIP49 P-loop domain AAA_3 PF07726.11 EMD63292.1 - 0.068 13.0 0.0 0.64 9.9 0.0 2.2 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) DEAD PF00270.29 EMD63292.1 - 0.095 12.5 0.1 0.95 9.2 0.0 2.3 1 1 1 2 2 2 0 DEAD/DEAH box helicase DNA_pol3_delta PF06144.13 EMD63292.1 - 0.11 12.2 0.0 0.23 11.2 0.0 1.5 1 0 0 1 1 1 0 DNA polymerase III, delta subunit RNA_helicase PF00910.22 EMD63292.1 - 0.12 12.8 0.0 0.3 11.5 0.0 1.7 1 0 0 1 1 1 0 RNA helicase Protocadherin PF08374.11 EMD63295.1 - 0.38 10.7 5.8 0.4 10.6 0.5 2.1 1 1 1 2 2 2 0 Protocadherin Tlr3_TMD PF17968.1 EMD63295.1 - 3.7 7.8 6.0 6.2 7.1 6.0 1.3 1 0 0 1 1 1 0 Toll-like receptor 3 trans-membrane domain CKS PF01111.19 EMD63296.1 - 9.3e-35 118.7 0.6 9.3e-35 118.7 0.6 1.3 2 0 0 2 2 2 1 Cyclin-dependent kinase regulatory subunit APC_15aa PF05972.11 EMD63296.1 - 0.42 11.0 2.7 2.5 8.5 0.3 2.5 2 0 0 2 2 2 0 APC 15 residue motif RNA_pol_Rpb2_5 PF04567.17 EMD63298.1 - 0.31 11.6 2.7 0.45 11.1 2.7 1.3 1 0 0 1 1 1 0 RNA polymerase Rpb2, domain 5 Fungal_trans PF04082.18 EMD63299.1 - 4.9e-21 75.0 0.0 4.8e-20 71.7 0.0 2.1 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD63299.1 - 0.00013 22.0 6.9 0.00024 21.2 6.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF2235 PF09994.9 EMD63301.1 - 1.7e-83 280.3 0.0 5.6e-83 278.6 0.0 1.7 1 1 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) SMP PF04927.12 EMD63302.1 - 3.1e-07 30.8 14.4 0.0094 16.4 1.3 3.4 3 0 0 3 3 3 3 Seed maturation protein Ifi-6-16 PF06140.13 EMD63302.1 - 0.0034 17.2 0.9 5.4 7.0 0.0 3.2 3 0 0 3 3 3 3 Interferon-induced 6-16 family LRR_6 PF13516.6 EMD63303.1 - 5.4e-11 41.6 8.6 0.23 11.6 0.1 7.0 7 0 0 7 7 7 3 Leucine Rich repeat LRR_4 PF12799.7 EMD63303.1 - 0.00012 22.3 12.3 0.75 10.3 0.8 5.2 3 2 2 5 5 5 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EMD63303.1 - 0.0095 16.4 1.6 33 5.6 0.0 5.2 7 0 0 7 7 7 0 Leucine Rich Repeat LRR_8 PF13855.6 EMD63303.1 - 0.015 15.0 9.3 0.68 9.7 0.0 4.7 3 2 0 3 3 3 0 Leucine rich repeat DUF604 PF04646.12 EMD63303.1 - 0.086 12.2 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF604 Radial_spoke PF04712.12 EMD63303.1 - 0.17 10.8 0.0 0.17 10.8 0.0 2.2 2 0 0 2 2 2 0 Radial spokehead-like protein Eaf7 PF07904.13 EMD63303.1 - 1.4 9.3 3.7 3.4 8.1 3.7 1.6 1 0 0 1 1 1 0 Chromatin modification-related protein EAF7 Alg6_Alg8 PF03155.15 EMD63304.1 - 2.8e-125 419.1 24.2 5.7e-80 269.6 10.2 2.2 2 0 0 2 2 2 2 ALG6, ALG8 glycosyltransferase family RRM_1 PF00076.22 EMD63305.1 - 6.4e-44 147.6 0.0 2.8e-21 75.1 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EMD63305.1 - 7e-06 26.1 0.0 0.16 12.1 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif RRM_occluded PF16842.5 EMD63305.1 - 0.00025 20.8 0.0 0.81 9.6 0.0 2.5 2 0 0 2 2 2 2 Occluded RNA-recognition motif RRM_5 PF13893.6 EMD63305.1 - 0.00078 19.0 0.0 0.023 14.3 0.0 2.3 1 1 1 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EMD63305.1 - 0.0013 18.7 0.0 0.27 11.3 0.0 2.4 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif Limkain-b1 PF11608.8 EMD63305.1 - 0.016 15.3 0.0 3.5 7.8 0.0 2.7 2 0 0 2 2 2 0 Limkain b1 Adeno_terminal PF02459.15 EMD63305.1 - 5.3 5.3 4.6 10 4.4 4.6 1.4 1 0 0 1 1 1 0 Adenoviral DNA terminal protein MFS_1 PF07690.16 EMD63306.1 - 1.9e-17 63.2 24.3 1.9e-17 63.2 24.3 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EMD63306.1 - 2.7e-06 26.6 2.1 2.7e-06 26.6 2.1 1.7 2 0 0 2 2 2 1 Sugar (and other) transporter zf-C2H2 PF00096.26 EMD63308.1 - 0.0047 17.3 5.1 0.0047 17.3 5.1 3.2 3 0 0 3 3 3 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMD63308.1 - 0.59 11.1 16.6 0.058 14.3 4.3 3.5 3 0 0 3 3 3 0 C2H2-type zinc finger zf-H2C2_5 PF13909.6 EMD63308.1 - 0.98 9.2 9.5 1.3 8.8 2.2 3.9 4 0 0 4 4 4 0 C2H2-type zinc-finger domain zf-H2C2_2 PF13465.6 EMD63308.1 - 8.4 7.0 12.7 15 6.2 0.1 3.6 3 0 0 3 3 3 0 Zinc-finger double domain HECT_2 PF09814.9 EMD63309.1 - 1.4e-106 356.5 0.0 1.6e-106 356.3 0.0 1.0 1 0 0 1 1 1 1 HECT-like Ubiquitin-conjugating enzyme (E2)-binding 3Beta_HSD PF01073.19 EMD63310.1 - 4.4e-68 229.3 0.0 5.7e-68 228.9 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EMD63310.1 - 1.5e-31 109.7 0.1 2e-31 109.3 0.1 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EMD63310.1 - 4.2e-21 75.7 0.1 2.3e-18 66.7 0.0 2.2 2 0 0 2 2 2 2 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 EMD63310.1 - 1.4e-14 53.9 0.0 3.2e-09 36.3 0.0 2.2 1 1 1 2 2 2 2 Male sterility protein RmlD_sub_bind PF04321.17 EMD63310.1 - 7.7e-11 41.6 0.1 1.2e-10 41.0 0.1 1.4 1 1 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 EMD63310.1 - 3.6e-10 39.5 0.0 2e-09 37.0 0.2 2.1 2 1 0 2 2 2 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.6 EMD63310.1 - 3.4e-09 36.9 0.0 4.8e-09 36.4 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EMD63310.1 - 2.1e-07 30.7 0.2 3.6e-07 30.0 0.2 1.3 1 0 0 1 1 1 1 NmrA-like family KR PF08659.10 EMD63310.1 - 6.3e-07 29.5 0.5 9.6e-06 25.6 0.5 2.4 1 1 0 1 1 1 1 KR domain Sacchrp_dh_NADP PF03435.18 EMD63310.1 - 0.02 15.2 0.1 0.037 14.3 0.1 1.5 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain UQ_con PF00179.26 EMD63311.1 - 9.3e-42 142.0 0.0 4.7e-29 100.8 0.0 2.2 2 0 0 2 2 2 2 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EMD63311.1 - 1.5e-05 24.7 0.0 0.00029 20.5 0.0 2.4 2 1 0 2 2 2 1 Prokaryotic E2 family B UEV PF05743.13 EMD63311.1 - 0.14 12.1 0.0 0.52 10.2 0.0 1.9 2 0 0 2 2 2 0 UEV domain Sybindin PF04099.12 EMD63312.1 - 2.1e-42 144.4 0.0 2.4e-42 144.3 0.0 1.0 1 0 0 1 1 1 1 Sybindin-like family Sedlin_N PF04628.13 EMD63312.1 - 9.2e-10 38.7 0.1 1.2e-09 38.3 0.1 1.1 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region DUF4478 PF14793.6 EMD63312.1 - 0.095 12.6 0.0 0.13 12.2 0.0 1.2 1 0 0 1 1 1 0 Pyrimidine/purine nucleotide 5'-monophosphate nucleosidases VWA_2 PF13519.6 EMD63313.1 - 2.6e-22 79.5 0.0 6.1e-22 78.3 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 EMD63313.1 - 5.1e-07 30.1 0.2 7.3e-07 29.6 0.2 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain Ssl1 PF04056.14 EMD63313.1 - 7.7e-06 25.8 0.0 9.9e-06 25.5 0.0 1.1 1 0 0 1 1 1 1 Ssl1-like UIM PF02809.20 EMD63313.1 - 0.33 11.0 0.1 0.33 11.0 0.1 2.2 2 0 0 2 2 2 0 Ubiquitin interaction motif Nbl1_Borealin_N PF10444.9 EMD63314.1 - 7e-14 51.2 1.3 1.3e-13 50.4 1.3 1.3 1 0 0 1 1 1 1 Nbl1 / Borealin N terminal DHHA2 PF02833.14 EMD63315.1 - 2.6e-15 56.9 0.1 4.1e-15 56.2 0.1 1.3 1 0 0 1 1 1 1 DHHA2 domain DHH PF01368.20 EMD63315.1 - 6.1e-10 39.2 0.0 1.1e-09 38.4 0.0 1.4 1 0 0 1 1 1 1 DHH family DUF2985 PF11204.8 EMD63316.1 - 2e-25 88.8 6.6 3.3e-25 88.0 6.6 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2985) HLH PF00010.26 EMD63317.1 - 3.4e-15 55.7 0.2 6.9e-15 54.7 0.2 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain SUIM_assoc PF16619.5 EMD63317.1 - 0.00099 19.1 2.2 0.006 16.6 2.2 2.5 1 0 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 Pkinase PF00069.25 EMD63321.1 - 1.1e-38 133.1 0.0 1.4e-21 77.0 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EMD63321.1 - 1.7e-17 63.6 0.0 2.6e-16 59.7 0.0 2.3 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EMD63321.1 - 3.3e-05 24.0 0.0 7e-05 22.9 0.0 1.7 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 EMD63321.1 - 0.027 13.8 0.0 4.1 6.6 0.0 2.2 2 0 0 2 2 2 0 Kinase-like Glyco_transf_8 PF01501.20 EMD63323.1 - 1.8e-11 44.1 0.0 3e-11 43.4 0.0 1.4 1 1 0 1 1 1 1 Glycosyl transferase family 8 LIG3_BRCT PF16759.5 EMD63323.1 - 0.13 12.5 0.1 0.21 11.9 0.1 1.3 1 0 0 1 1 1 0 DNA ligase 3 BRCT domain Mannosyl_trans3 PF11051.8 EMD63323.1 - 0.22 10.9 0.0 0.3 10.4 0.0 1.2 1 0 0 1 1 1 0 Mannosyltransferase putative Sec63 PF02889.16 EMD63324.1 - 1.5e-164 545.3 0.1 2.8e-89 298.7 0.0 2.3 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.29 EMD63324.1 - 1.7e-46 158.2 0.2 1.7e-26 93.1 0.0 3.1 3 0 0 3 3 3 2 DEAD/DEAH box helicase Helicase_PWI PF18149.1 EMD63324.1 - 7.2e-32 109.9 6.3 8.9e-32 109.6 4.0 2.4 2 0 0 2 2 2 1 N-terminal helicase PWI domain ResIII PF04851.15 EMD63324.1 - 5.2e-24 85.2 0.0 1.2e-12 48.2 0.0 3.0 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EMD63324.1 - 3e-10 40.4 0.0 2.5e-08 34.2 0.0 3.6 2 1 0 2 2 2 1 Helicase conserved C-terminal domain AAA_30 PF13604.6 EMD63324.1 - 0.00045 20.0 0.0 0.21 11.3 0.0 2.9 2 1 0 2 2 2 2 AAA domain AAA_22 PF13401.6 EMD63324.1 - 0.0025 18.1 0.6 0.84 9.9 0.1 3.4 2 2 0 2 2 2 1 AAA domain AAA_19 PF13245.6 EMD63324.1 - 0.0075 16.6 0.3 4.4 7.6 0.0 3.3 3 0 0 3 3 3 1 AAA domain UvrD-helicase PF00580.21 EMD63324.1 - 0.0085 15.6 1.9 3 7.3 0.0 3.6 3 0 0 3 3 3 1 UvrD/REP helicase N-terminal domain TFIIE_alpha PF02002.17 EMD63324.1 - 0.056 13.3 0.3 26 4.7 0.0 3.5 2 0 0 2 2 2 0 TFIIE alpha subunit SUI1 PF01253.22 EMD63325.1 - 4.5e-26 91.2 0.1 4.5e-26 91.2 0.1 1.6 2 0 0 2 2 2 1 Translation initiation factor SUI1 R3H-assoc PF13902.6 EMD63325.1 - 0.034 14.5 0.7 0.055 13.8 0.7 1.3 1 0 0 1 1 1 0 R3H-associated N-terminal domain Glyco_transf_22 PF03901.17 EMD63326.1 - 5.2e-39 134.7 20.4 8.6e-39 133.9 20.4 1.3 1 1 0 1 1 1 1 Alg9-like mannosyltransferase family FAM124 PF15067.6 EMD63326.1 - 0.1 12.2 0.0 0.15 11.6 0.0 1.2 1 0 0 1 1 1 0 FAM124 family DHHC PF01529.20 EMD63327.1 - 1.5e-33 115.8 6.0 2.5e-33 115.0 6.0 1.4 1 0 0 1 1 1 1 DHHC palmitoyltransferase COPI_C PF06957.11 EMD63327.1 - 7.1 5.3 7.1 9.8 4.8 7.1 1.1 1 0 0 1 1 1 0 Coatomer (COPI) alpha subunit C-terminus CBFD_NFYB_HMF PF00808.23 EMD63328.1 - 4.3e-29 100.6 1.5 6.7e-29 100.0 1.5 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EMD63328.1 - 2.8e-06 27.7 0.1 4e-06 27.2 0.1 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TFIID-18kDa PF02269.16 EMD63328.1 - 0.00068 19.6 0.0 0.0012 18.9 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit Bromo_TP PF07524.13 EMD63328.1 - 0.0011 19.0 0.1 0.0017 18.3 0.1 1.3 1 0 0 1 1 1 1 Bromodomain associated CENP-T_C PF15511.6 EMD63328.1 - 0.0018 18.4 0.0 0.0025 17.9 0.0 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TFIID_20kDa PF03847.13 EMD63328.1 - 0.032 14.7 0.2 0.079 13.5 0.1 1.6 2 0 0 2 2 2 0 Transcription initiation factor TFIID subunit A Prefoldin_2 PF01920.20 EMD63330.1 - 2.4e-24 85.3 10.4 3e-24 85.0 10.4 1.1 1 0 0 1 1 1 1 Prefoldin subunit PhaP_Bmeg PF09602.10 EMD63330.1 - 0.0037 17.2 3.4 0.1 12.5 0.3 2.1 1 1 0 2 2 2 1 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) Prefoldin PF02996.17 EMD63330.1 - 0.0046 16.9 9.9 0.27 11.2 9.9 2.2 1 1 0 1 1 1 1 Prefoldin subunit SAS-6_N PF16531.5 EMD63330.1 - 0.039 14.5 0.4 0.066 13.8 0.4 1.6 1 1 0 1 1 1 0 Centriolar protein SAS N-terminal SLATT_1 PF18181.1 EMD63330.1 - 0.064 13.2 0.3 0.064 13.2 0.3 1.8 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain 1 WXG100 PF06013.12 EMD63330.1 - 0.082 13.1 4.5 0.4 11.0 1.8 2.2 2 0 0 2 2 2 0 Proteins of 100 residues with WXG UvrD_C PF13361.6 EMD63330.1 - 0.1 12.0 2.9 0.11 11.8 2.9 1.0 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain Com_YlbF PF06133.11 EMD63330.1 - 0.23 12.1 8.7 0.83 10.3 1.2 2.1 2 0 0 2 2 2 0 Control of competence regulator ComK, YlbF/YmcA V_ATPase_I PF01496.19 EMD63330.1 - 0.27 9.1 4.0 0.32 8.9 4.0 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF2089 PF09862.9 EMD63330.1 - 0.38 10.8 5.3 0.9 9.6 0.5 2.0 1 1 0 2 2 2 0 Protein of unknown function (DUF2089) CLZ PF16526.5 EMD63330.1 - 0.46 10.9 6.1 1.3 9.5 0.2 2.2 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF4795 PF16043.5 EMD63330.1 - 1.3 8.6 8.9 23 4.5 8.9 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) Rx_N PF18052.1 EMD63330.1 - 1.6 9.1 5.4 1.5 9.1 0.4 2.3 2 1 0 2 2 2 0 Rx N-terminal domain Cep57_MT_bd PF06657.13 EMD63330.1 - 2.8 8.5 9.2 0.36 11.3 0.4 2.7 2 1 1 3 3 3 0 Centrosome microtubule-binding domain of Cep57 DUF2205 PF10224.9 EMD63330.1 - 4.1 7.5 8.9 0.98 9.5 1.5 2.2 2 0 0 2 2 2 0 Short coiled-coil protein Cmc1 PF08583.10 EMD63331.1 - 1.4e-16 60.3 3.5 1.6e-16 60.1 3.5 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like RPN7 PF10602.9 EMD63331.1 - 0.0019 17.9 0.0 0.0019 17.9 0.0 1.2 1 0 0 1 1 1 1 26S proteasome subunit RPN7 NDUF_B7 PF05676.13 EMD63331.1 - 0.0053 16.5 0.6 0.0077 15.9 0.6 1.3 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) DUF728 PF05304.12 EMD63331.1 - 0.027 14.3 2.1 0.03 14.2 2.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF728) Antimicrobial_6 PF08036.11 EMD63331.1 - 0.043 13.9 0.0 0.1 12.7 0.0 1.7 1 0 0 1 1 1 0 Diapausin family of antimicrobial peptide UPF0242 PF06785.11 EMD63332.1 - 0.013 15.6 1.0 0.013 15.6 1.0 2.1 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus RasGAP_C PF03836.15 EMD63332.1 - 0.018 15.2 0.7 0.035 14.2 0.0 1.8 2 0 0 2 2 2 0 RasGAP C-terminus LSM PF01423.22 EMD63333.1 - 2e-19 69.0 0.4 2.2e-19 68.9 0.4 1.1 1 0 0 1 1 1 1 LSM domain Cas_NE0113 PF09623.10 EMD63333.1 - 0.1 12.3 0.0 0.13 11.9 0.0 1.2 1 0 0 1 1 1 0 CRISPR-associated protein NE0113 (Cas_NE0113) APH PF01636.23 EMD63334.1 - 7.6e-39 134.1 0.0 1.4e-38 133.2 0.0 1.4 2 0 0 2 2 2 1 Phosphotransferase enzyme family EcKinase PF02958.20 EMD63334.1 - 1.7e-05 24.3 0.0 3.7e-05 23.2 0.0 1.7 1 1 0 1 1 1 1 Ecdysteroid kinase Choline_kinase PF01633.20 EMD63334.1 - 0.00083 19.0 0.0 0.0013 18.3 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase Kdo PF06293.14 EMD63334.1 - 0.0026 17.1 0.0 0.021 14.2 0.0 2.1 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 EMD63334.1 - 0.0042 16.7 0.0 0.1 12.2 0.0 2.4 2 0 0 2 2 2 1 RIO1 family Fructosamin_kin PF03881.14 EMD63334.1 - 0.027 13.7 0.0 0.75 8.9 0.0 2.5 1 1 0 1 1 1 0 Fructosamine kinase CAP_GLY PF01302.25 EMD63335.1 - 1.7e-16 60.0 0.8 3.5e-16 59.0 0.8 1.6 1 0 0 1 1 1 1 CAP-Gly domain CLIP1_ZNF PF16641.5 EMD63335.1 - 3.3e-05 23.6 17.1 6.1e-05 22.8 3.1 2.9 3 0 0 3 3 3 2 CLIP1 zinc knuckle Spc7 PF08317.11 EMD63335.1 - 0.0027 16.6 30.8 0.052 12.4 9.4 3.4 2 1 2 4 4 4 4 Spc7 kinetochore protein PI3K_P85_iSH2 PF16454.5 EMD63335.1 - 0.0061 16.2 1.5 0.0061 16.2 1.5 3.3 3 1 0 3 3 3 1 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain NPV_P10 PF05531.12 EMD63335.1 - 0.0081 16.6 4.5 1 9.9 0.5 2.9 3 0 0 3 3 2 2 Nucleopolyhedrovirus P10 protein Laps PF10169.9 EMD63335.1 - 0.028 15.0 0.6 0.028 15.0 0.6 2.4 2 0 0 2 2 2 0 Learning-associated protein Paramyx_P_V_C PF03210.13 EMD63335.1 - 0.046 13.5 0.0 0.13 12.0 0.0 1.8 1 0 0 1 1 1 0 Paramyxovirus P/V phosphoprotein C-terminal Fib_alpha PF08702.10 EMD63335.1 - 0.13 12.5 12.0 4.7 7.4 1.2 4.1 2 1 2 4 4 4 0 Fibrinogen alpha/beta chain family Baculo_PEP_C PF04513.12 EMD63335.1 - 0.47 10.5 2.8 1.2 9.1 0.3 2.3 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Fez1 PF06818.15 EMD63335.1 - 0.59 10.6 32.1 0.072 13.5 11.1 3.4 3 1 0 3 3 3 0 Fez1 DUF241 PF03087.14 EMD63335.1 - 0.6 9.9 10.7 0.5 10.1 6.0 2.4 2 1 0 2 2 2 0 Arabidopsis protein of unknown function ATG16 PF08614.11 EMD63335.1 - 0.9 9.7 38.0 0.3 11.3 4.2 3.7 2 1 1 3 3 3 0 Autophagy protein 16 (ATG16) DUF1664 PF07889.12 EMD63335.1 - 1.5 8.9 9.4 0.79 9.8 1.1 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) DUF3450 PF11932.8 EMD63335.1 - 4.2 6.6 21.9 1.1 8.5 3.0 3.6 4 0 0 4 4 4 0 Protein of unknown function (DUF3450) HMMR_N PF15905.5 EMD63335.1 - 4.4 6.7 28.0 0.78 9.2 1.8 3.1 2 1 1 3 3 3 0 Hyaluronan mediated motility receptor N-terminal HemX PF04375.14 EMD63335.1 - 7.9 5.7 17.3 0.97 8.7 2.2 3.2 2 1 1 3 3 3 0 HemX, putative uroporphyrinogen-III C-methyltransferase DUF812 PF05667.11 EMD63335.1 - 9 5.0 28.4 0.095 11.6 15.0 2.6 1 1 0 2 2 2 0 Protein of unknown function (DUF812) GNAT_acetyltr_2 PF13718.6 EMD63337.1 - 9.3e-100 332.7 0.0 1.9e-99 331.7 0.0 1.6 1 0 0 1 1 1 1 GNAT acetyltransferase 2 tRNA_bind_2 PF13725.6 EMD63337.1 - 3.2e-88 295.4 0.1 6.6e-88 294.4 0.1 1.6 1 0 0 1 1 1 1 Possible tRNA binding domain Helicase_RecD PF05127.14 EMD63337.1 - 8.2e-65 218.0 0.0 3e-64 216.1 0.0 2.0 1 0 0 1 1 1 1 Helicase DUF1726 PF08351.11 EMD63337.1 - 4.6e-34 116.2 0.3 1.2e-33 114.9 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF1726) AAA_30 PF13604.6 EMD63337.1 - 9e-05 22.3 0.2 0.019 14.7 0.0 3.1 3 1 0 3 3 3 1 AAA domain AAA_22 PF13401.6 EMD63337.1 - 0.00069 19.9 0.2 0.023 15.0 0.0 2.9 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 EMD63337.1 - 0.026 14.9 0.0 0.095 13.0 0.0 2.0 2 0 0 2 2 2 0 AAA domain DUF1510 PF07423.11 EMD63337.1 - 0.11 12.7 0.2 0.26 11.4 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1510) INSC_LBD PF16748.5 EMD63337.1 - 0.13 11.7 2.0 0.64 9.5 0.2 2.9 3 0 0 3 3 3 0 Inscuteable LGN-binding domain Acetyltransf_1 PF00583.25 EMD63337.1 - 0.14 12.4 0.0 0.93 9.7 0.0 2.4 2 0 0 2 2 2 0 Acetyltransferase (GNAT) family Peptidase_S9 PF00326.21 EMD63338.1 - 1.1e-52 178.6 0.2 1.7e-52 178.0 0.2 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family PD40 PF07676.12 EMD63338.1 - 3.7e-06 26.7 1.3 0.01 15.8 0.2 3.2 3 0 0 3 3 3 2 WD40-like Beta Propeller Repeat TDRP PF15683.5 EMD63338.1 - 0.079 12.9 0.1 0.17 11.8 0.1 1.5 1 0 0 1 1 1 0 Testis development-related protein PhoD PF09423.10 EMD63339.1 - 1.7e-08 33.9 0.1 1.2e-07 31.1 0.1 2.0 1 1 0 1 1 1 1 PhoD-like phosphatase Peptidase_S8 PF00082.22 EMD63340.1 - 6.3e-37 127.4 3.1 6.3e-37 127.4 3.1 1.7 2 0 0 2 2 2 1 Subtilase family P_proprotein PF01483.20 EMD63340.1 - 4.5e-27 93.9 0.1 8.4e-27 93.0 0.1 1.5 1 0 0 1 1 1 1 Proprotein convertase P-domain S8_pro-domain PF16470.5 EMD63340.1 - 0.017 15.9 0.4 0.043 14.6 0.4 1.8 1 0 0 1 1 1 0 Peptidase S8 pro-domain RTC_insert PF05189.13 EMD63341.1 - 1.7e-29 102.3 0.0 3.5e-29 101.3 0.0 1.6 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain RTC PF01137.21 EMD63341.1 - 5.3e-29 101.0 0.1 6.6e-29 100.7 0.1 1.0 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase RTC4 PF14474.6 EMD63342.1 - 1.2e-28 99.7 0.0 2.9e-28 98.4 0.0 1.7 1 0 0 1 1 1 1 RTC4-like domain GTP_EFTU PF00009.27 EMD63343.1 - 6.8e-46 156.3 0.0 9.8e-46 155.7 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFTUD2 PF16004.5 EMD63343.1 - 5.4e-35 120.6 6.9 1.1e-34 119.6 6.9 1.6 1 0 0 1 1 1 1 116 kDa U5 small nuclear ribonucleoprotein component N-terminus EFG_IV PF03764.18 EMD63343.1 - 7.1e-23 80.7 0.0 3.1e-22 78.6 0.0 2.1 2 0 0 2 2 2 1 Elongation factor G, domain IV EFG_C PF00679.24 EMD63343.1 - 1.5e-17 63.4 0.0 3.8e-17 62.1 0.0 1.8 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 EMD63343.1 - 1.3e-08 35.1 0.1 3.8e-08 33.6 0.1 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.6 EMD63343.1 - 1.2e-06 28.5 0.0 2.9e-06 27.3 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II MMR_HSR1 PF01926.23 EMD63343.1 - 0.00016 21.7 0.1 0.00039 20.5 0.1 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase Ras PF00071.22 EMD63343.1 - 0.053 13.1 0.0 0.11 12.0 0.0 1.5 1 0 0 1 1 1 0 Ras family SRPRB PF09439.10 EMD63343.1 - 0.13 11.7 0.1 1.2 8.5 0.1 2.4 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit Thiolase_N PF00108.23 EMD63344.1 - 5.7e-93 311.0 0.4 1e-92 310.2 0.4 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EMD63344.1 - 2.4e-43 146.7 3.4 3.1e-42 143.1 2.5 2.3 2 0 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 EMD63344.1 - 7.6e-06 25.7 3.0 0.0031 17.1 2.2 3.0 2 1 1 3 3 3 2 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.10 EMD63344.1 - 0.00011 22.0 4.1 0.0052 16.6 0.1 3.2 3 0 0 3 3 3 2 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Glyco_hydro_16 PF00722.21 EMD63345.1 - 9.8e-08 31.7 0.0 2.4e-07 30.4 0.0 1.7 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 HET PF06985.11 EMD63346.1 - 1e-17 64.9 0.0 2e-17 63.9 0.0 1.6 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Telomere_reg-2 PF10193.9 EMD63347.1 - 2.5e-36 124.4 0.3 1.4e-35 122.1 0.1 2.4 2 0 0 2 2 2 1 Telomere length regulation protein Dpoe2NT PF12213.8 EMD63347.1 - 0.088 13.1 0.3 0.44 10.9 0.0 2.2 2 0 0 2 2 2 0 DNA polymerases epsilon N terminal ThiF PF00899.21 EMD63348.1 - 3.9e-63 213.1 0.0 5.5e-63 212.6 0.0 1.2 1 0 0 1 1 1 1 ThiF family E2_bind PF08825.10 EMD63348.1 - 9.4e-28 96.2 0.1 1.5e-27 95.5 0.1 1.3 1 0 0 1 1 1 1 E2 binding domain Shikimate_DH PF01488.20 EMD63348.1 - 0.00011 22.2 0.3 0.00054 20.0 0.0 2.1 2 1 1 3 3 3 1 Shikimate / quinate 5-dehydrogenase Pyr_redox PF00070.27 EMD63348.1 - 0.044 14.3 0.1 0.19 12.3 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Ecm33 PF12454.8 EMD63348.1 - 0.093 12.9 1.0 0.2 11.9 1.0 1.4 1 0 0 1 1 1 0 GPI-anchored cell wall organization protein Sacchrp_dh_NADP PF03435.18 EMD63348.1 - 0.11 12.8 0.1 0.25 11.6 0.1 1.7 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain PglD_N PF17836.1 EMD63348.1 - 0.15 12.8 0.7 0.47 11.1 0.4 2.1 1 1 0 1 1 1 0 PglD N-terminal domain UBA_e1_thiolCys PF10585.9 EMD63348.1 - 0.36 10.7 2.5 7.4 6.4 0.0 2.4 2 0 0 2 2 2 0 Ubiquitin-activating enzyme active site ANAPC_CDC26 PF10471.9 EMD63350.1 - 2.7e-12 47.3 12.5 4.9e-12 46.5 12.5 1.4 1 1 0 1 1 1 1 Anaphase-promoting complex APC subunit CDC26 Selenoprotein_S PF06936.11 EMD63350.1 - 0.0038 17.1 4.5 0.0046 16.8 4.5 1.0 1 0 0 1 1 1 1 Selenoprotein S (SelS) DUF2406 PF10295.9 EMD63351.1 - 2e-25 89.2 0.4 7.3e-25 87.4 0.1 2.1 2 0 0 2 2 2 1 Uncharacterised protein (DUF2406) Aldedh PF00171.22 EMD63353.1 - 4.6e-138 460.6 0.3 5.4e-138 460.4 0.3 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Calreticulin PF00262.18 EMD63354.1 - 5.9e-173 574.9 17.3 5.9e-173 574.9 17.3 1.9 2 0 0 2 2 2 1 Calreticulin family DUF1911 PF08929.10 EMD63354.1 - 0.039 14.8 0.0 0.096 13.5 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1911) DUF1752 PF08550.10 EMD63355.1 - 4.1e-09 36.1 3.8 9.2e-09 35.0 3.8 1.6 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) MFS_1 PF07690.16 EMD63357.1 - 6.1e-51 173.4 54.2 4.2e-48 164.1 53.7 2.8 2 1 0 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EMD63357.1 - 1e-20 73.8 13.4 1e-20 73.8 13.4 1.6 1 1 1 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EMD63357.1 - 2.6e-15 56.3 9.0 2.6e-15 56.3 9.0 3.2 2 1 1 3 3 3 1 Sugar (and other) transporter NDUFB10 PF10249.9 EMD63358.1 - 0.0017 18.8 0.1 0.002 18.6 0.1 1.1 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase subunit 10 HWE_HK PF07536.14 EMD63358.1 - 0.046 14.4 0.0 0.068 13.9 0.0 1.2 1 0 0 1 1 1 0 HWE histidine kinase BRO1 PF03097.18 EMD63359.1 - 4.9e-13 48.6 0.0 7.8e-13 48.0 0.0 1.3 1 0 0 1 1 1 1 BRO1-like domain AA_permease_2 PF13520.6 EMD63361.1 - 3.4e-53 181.0 56.1 4.6e-53 180.6 56.1 1.2 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EMD63361.1 - 2.2e-13 49.7 40.8 3.2e-13 49.1 40.8 1.3 1 0 0 1 1 1 1 Amino acid permease zf-C2H2_2 PF12756.7 EMD63370.1 - 5.2e-08 33.1 16.9 0.0066 16.8 3.1 4.1 2 1 2 4 4 4 3 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.8 EMD63370.1 - 3.8e-06 27.0 29.8 0.00054 20.2 1.9 6.0 5 1 1 6 6 6 2 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 EMD63370.1 - 4.2e-06 27.1 29.1 0.035 15.0 0.8 7.7 8 0 0 8 8 8 3 C2H2-type zinc finger zf-C2H2 PF00096.26 EMD63370.1 - 4.3e-05 23.7 27.9 0.0069 16.8 1.7 7.0 7 0 0 7 7 7 3 Zinc finger, C2H2 type zf-met PF12874.7 EMD63370.1 - 0.04 14.3 2.6 0.04 14.3 2.6 6.2 6 1 0 6 6 6 0 Zinc-finger of C2H2 type Rad50_zn_hook PF04423.14 EMD63370.1 - 0.065 13.1 0.2 0.2 11.5 0.2 1.8 1 0 0 1 1 1 0 Rad50 zinc hook motif Zn-ribbon_8 PF09723.10 EMD63370.1 - 3.1 8.0 11.0 8.1 6.7 0.3 3.8 3 1 0 3 3 3 0 Zinc ribbon domain zf-C2H2_9 PF16293.5 EMD63370.1 - 4 7.4 9.4 1.9 8.4 0.6 3.3 4 0 0 4 4 4 0 C2H2 type zinc-finger (1 copy) zf-DBF PF07535.12 EMD63370.1 - 5.7 7.1 13.0 5.2 7.3 3.7 3.9 4 1 0 4 4 4 0 DBF zinc finger zf-C2HE PF16278.5 EMD63370.1 - 8.7 6.9 11.8 6.3 7.3 1.2 4.1 3 1 1 4 4 4 0 C2HE / C2H2 / C2HC zinc-binding finger DNase_NucA_NucB PF14040.6 EMD63372.1 - 1.7e-33 115.4 2.5 2.5e-33 114.9 2.5 1.2 1 0 0 1 1 1 1 Deoxyribonuclease NucA/NucB EHN PF06441.12 EMD63373.1 - 0.00039 20.8 0.2 0.00072 19.9 0.2 1.4 1 1 0 1 1 1 1 Epoxide hydrolase N terminus Abhydrolase_1 PF00561.20 EMD63373.1 - 0.0021 17.8 0.0 0.0043 16.7 0.0 1.6 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EMD63373.1 - 0.085 13.4 0.0 0.13 12.8 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family Ferric_reduct PF01794.19 EMD63374.1 - 1.1e-21 77.3 13.1 1.1e-21 77.3 13.1 2.0 2 0 0 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 EMD63374.1 - 1.7e-13 51.0 0.2 5.2e-12 46.2 0.2 2.3 1 1 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EMD63374.1 - 4e-08 33.3 0.0 0.0029 17.7 0.0 2.6 2 0 0 2 2 2 2 FAD-binding domain Epimerase PF01370.21 EMD63375.1 - 1.6e-10 40.9 0.1 5.1e-10 39.2 0.1 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EMD63375.1 - 8e-08 32.4 0.0 1.6e-07 31.4 0.0 1.5 1 0 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 EMD63375.1 - 4.3e-05 22.7 0.0 0.00016 20.8 0.0 1.8 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NmrA PF05368.13 EMD63375.1 - 0.00028 20.5 0.1 0.00062 19.4 0.1 1.6 1 1 0 1 1 1 1 NmrA-like family adh_short PF00106.25 EMD63375.1 - 0.016 14.7 0.1 0.056 12.9 0.0 2.0 2 0 0 2 2 2 0 short chain dehydrogenase GDP_Man_Dehyd PF16363.5 EMD63375.1 - 0.14 11.6 0.0 0.26 10.6 0.0 1.4 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Mem_trans PF03547.18 EMD63376.1 - 1.8e-20 72.7 4.5 4e-20 71.6 4.5 1.5 1 1 0 1 1 1 1 Membrane transport protein Glyco_hydro_31 PF01055.26 EMD63377.1 - 4.9e-85 286.4 0.4 6.2e-85 286.0 0.4 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 MFS_1 PF07690.16 EMD63378.1 - 1.2e-27 96.8 33.1 1.2e-27 96.8 33.1 2.1 1 1 0 2 2 2 1 Major Facilitator Superfamily SBF PF01758.16 EMD63378.1 - 0.31 10.7 11.5 0.13 11.9 3.9 2.9 2 0 0 2 2 2 0 Sodium Bile acid symporter family DUF2070 PF09843.9 EMD63378.1 - 0.8 7.9 12.9 0.76 8.0 0.6 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2070) Vpu PF00558.19 EMD63378.1 - 7.5 6.4 9.0 6.5 6.6 1.6 3.2 3 1 0 3 3 3 0 Vpu protein Zn_clus PF00172.18 EMD63379.1 - 2.3e-10 40.4 10.7 4e-10 39.6 10.7 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PIF PF05092.12 EMD63379.1 - 0.05 12.3 1.2 0.083 11.6 1.2 1.2 1 0 0 1 1 1 0 Per os infectivity FAD_binding_3 PF01494.19 EMD63380.1 - 8.9e-17 61.3 2.4 6e-13 48.8 2.0 2.9 2 1 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 EMD63380.1 - 0.00039 20.6 0.1 0.0021 18.3 0.0 2.3 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain DEAD PF00270.29 EMD63381.1 - 1.9e-28 99.4 0.1 2.9e-28 98.8 0.1 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EMD63381.1 - 9.1e-20 71.1 0.0 1.3e-18 67.3 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EMD63381.1 - 0.0012 18.9 0.0 0.0081 16.2 0.0 2.1 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit DUF3323 PF11796.8 EMD63381.1 - 0.092 12.6 3.0 0.16 11.8 3.0 1.3 1 0 0 1 1 1 0 Protein of unknown function N-terminus (DUF3323) PH PF00169.29 EMD63382.1 - 3.1e-08 34.1 0.0 9.3e-08 32.5 0.0 1.9 1 0 0 1 1 1 1 PH domain Anillin PF08174.11 EMD63382.1 - 4.8e-05 23.8 0.0 0.00016 22.1 0.0 2.0 1 0 0 1 1 1 1 Cell division protein anillin PH_11 PF15413.6 EMD63382.1 - 0.054 13.9 0.0 0.16 12.4 0.0 1.9 1 0 0 1 1 1 0 Pleckstrin homology domain DUF2205 PF10224.9 EMD63383.1 - 0.15 12.1 0.5 0.31 11.1 0.5 1.5 1 0 0 1 1 1 0 Short coiled-coil protein SR-25 PF10500.9 EMD63383.1 - 1.8 8.1 22.2 0.23 11.1 12.6 2.4 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Rotamase PF00639.21 EMD63386.1 - 4.5e-22 78.8 0.2 7.9e-22 78.0 0.2 1.4 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_3 PF13616.6 EMD63386.1 - 1.6e-16 60.9 0.2 2.8e-16 60.1 0.2 1.4 1 1 0 1 1 1 1 PPIC-type PPIASE domain WW PF00397.26 EMD63386.1 - 1.4e-08 34.7 1.4 2.6e-08 33.8 1.4 1.5 1 0 0 1 1 1 1 WW domain Rotamase_2 PF13145.6 EMD63386.1 - 4.5e-06 27.5 0.3 8.2e-06 26.7 0.0 1.6 2 0 0 2 2 2 1 PPIC-type PPIASE domain X8 PF07983.13 EMD63386.1 - 0.014 16.0 0.1 0.028 15.1 0.1 1.4 1 0 0 1 1 1 0 X8 domain TFIIS_C PF01096.18 EMD63387.1 - 6.2e-13 48.4 2.7 6.2e-13 48.4 2.7 2.9 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.16 EMD63387.1 - 2.2e-10 40.2 3.5 2.2e-10 40.2 3.5 2.6 3 0 0 3 3 3 1 RNA polymerases M/15 Kd subunit DZR PF12773.7 EMD63387.1 - 0.029 14.4 8.8 0.073 13.1 0.6 2.6 2 1 0 2 2 2 0 Double zinc ribbon Nudix_N_2 PF14803.6 EMD63387.1 - 0.062 13.2 12.5 0.2 11.6 0.5 3.1 2 1 0 2 2 2 0 Nudix N-terminal YhfH PF14149.6 EMD63387.1 - 0.27 11.3 0.2 0.27 11.3 0.2 2.8 3 0 0 3 3 3 0 YhfH-like protein zf-ribbon_3 PF13248.6 EMD63387.1 - 0.5 9.9 4.3 11 5.6 0.1 3.3 3 0 0 3 3 3 0 zinc-ribbon domain TF_Zn_Ribbon PF08271.12 EMD63387.1 - 0.73 9.4 6.4 1.3 8.6 2.9 2.8 2 1 0 2 2 2 0 TFIIB zinc-binding DUF3268 PF11672.8 EMD63387.1 - 0.84 10.0 4.1 1.8 8.9 0.9 2.1 2 0 0 2 2 2 0 zinc-finger-containing domain zf-UBP PF02148.19 EMD63387.1 - 1.1 9.6 6.2 4.9 7.6 0.3 2.3 2 0 0 2 2 2 0 Zn-finger in ubiquitin-hydrolases and other protein Zn_Tnp_IS91 PF14319.6 EMD63387.1 - 1.8 8.6 12.5 8.3 6.5 0.1 3.6 2 1 2 4 4 4 0 Transposase zinc-binding domain C1_1 PF00130.22 EMD63387.1 - 3.3 7.7 9.9 0.17 11.8 0.9 2.5 2 1 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Zn-ribbon_8 PF09723.10 EMD63387.1 - 3.6 7.8 11.4 13 6.0 0.1 3.5 3 1 1 4 4 4 0 Zinc ribbon domain Lar_restr_allev PF14354.6 EMD63387.1 - 5.8 7.4 8.9 2.1 8.8 2.1 2.4 1 1 0 2 2 2 0 Restriction alleviation protein Lar Rubredoxin_2 PF18073.1 EMD63387.1 - 6.5 6.6 14.3 6.7 6.5 0.3 4.0 4 0 0 4 4 4 0 Rubredoxin metal binding domain zinc_ribbon_15 PF17032.5 EMD63387.1 - 8.6 7.2 10.3 5.2 7.9 0.9 3.0 1 1 2 3 3 3 0 zinc-ribbon family Ribosomal_L14 PF00238.19 EMD63388.1 - 2.7e-48 163.1 3.1 3e-48 162.9 3.1 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e Phage_antitermQ PF06530.12 EMD63388.1 - 0.068 13.1 0.1 0.13 12.2 0.1 1.4 1 0 0 1 1 1 0 Phage antitermination protein Q SET PF00856.28 EMD63389.1 - 9.8e-13 48.8 0.0 8.7e-10 39.2 0.0 2.9 2 0 0 2 2 2 2 SET domain Tmemb_55A PF09788.9 EMD63389.1 - 0.074 12.1 0.2 0.13 11.3 0.2 1.3 1 0 0 1 1 1 0 Transmembrane protein 55A DUF4360 PF14273.6 EMD63390.1 - 4.7e-18 65.7 0.4 8.1e-18 64.9 0.4 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4360) DUF2428 PF10350.9 EMD63392.1 - 4.1e-69 232.9 0.1 3.8e-68 229.7 0.0 2.3 2 0 0 2 2 2 1 Putative death-receptor fusion protein (DUF2428) HEAT PF02985.22 EMD63392.1 - 2.4e-05 24.2 19.3 2 8.9 0.1 8.2 9 0 0 9 9 9 3 HEAT repeat HEAT_2 PF13646.6 EMD63392.1 - 0.00017 21.9 4.6 5.7 7.4 0.0 6.1 6 1 1 7 7 7 2 HEAT repeats DUF4042 PF13251.6 EMD63392.1 - 0.052 13.2 0.4 0.22 11.2 0.4 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4042) HEAT_EZ PF13513.6 EMD63392.1 - 0.12 12.9 3.6 2.8 8.6 0.4 4.0 3 0 0 3 3 3 0 HEAT-like repeat Arm PF00514.23 EMD63392.1 - 0.21 11.7 2.3 32 4.8 0.0 3.6 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat MBOAT PF03062.19 EMD63393.1 - 5.4e-20 72.0 14.0 5.4e-20 72.0 14.0 1.7 2 1 0 2 2 2 1 MBOAT, membrane-bound O-acyltransferase family MBOAT_2 PF13813.6 EMD63393.1 - 2e-05 24.7 0.4 7.6e-05 22.9 0.4 2.0 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family ADD_ATRX PF17981.1 EMD63393.1 - 0.094 12.6 0.2 0.24 11.3 0.2 1.7 1 0 0 1 1 1 0 Cysteine Rich ADD domain WD40 PF00400.32 EMD63394.1 - 6.1e-31 106.0 15.9 3.7e-07 30.7 1.1 7.5 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD63394.1 - 3e-11 43.5 0.9 0.0093 16.2 0.1 5.2 2 1 2 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EMD63394.1 - 0.0005 20.0 0.2 0.083 12.8 0.1 2.5 1 1 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 EMD63394.1 - 0.039 13.3 0.0 2.6 7.3 0.0 2.1 2 0 0 2 2 2 0 WD40-like domain Nucleoporin_N PF08801.11 EMD63394.1 - 0.041 12.6 0.0 0.19 10.4 0.0 2.0 2 0 0 2 2 2 0 Nup133 N terminal like HK PF02110.15 EMD63395.1 - 6.7e-73 245.1 0.7 1.5e-72 243.9 0.7 1.5 1 0 0 1 1 1 1 Hydroxyethylthiazole kinase family TMP-TENI PF02581.17 EMD63395.1 - 8.1e-55 184.9 1.6 1.4e-54 184.2 1.6 1.4 1 0 0 1 1 1 1 Thiamine monophosphate synthase Carb_kinase PF01256.17 EMD63395.1 - 0.0071 15.8 1.7 0.0089 15.5 0.2 1.9 2 0 0 2 2 2 1 Carbohydrate kinase PfkB PF00294.24 EMD63395.1 - 0.018 14.4 0.0 0.033 13.5 0.0 1.5 1 0 0 1 1 1 0 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.12 EMD63395.1 - 0.032 13.6 0.2 0.1 11.9 0.2 1.9 1 1 0 1 1 1 0 Phosphomethylpyrimidine kinase eIF-5_eIF-2B PF01873.17 EMD63396.1 - 2.5e-39 133.7 0.0 5.4e-39 132.7 0.0 1.6 1 0 0 1 1 1 1 Domain found in IF2B/IF5 W2 PF02020.18 EMD63396.1 - 7.2e-17 61.3 1.5 7.2e-17 61.3 1.5 2.2 3 0 0 3 3 3 1 eIF4-gamma/eIF5/eIF2-epsilon SLC35F PF06027.12 EMD63397.1 - 1e-99 333.8 24.8 1.3e-99 333.6 24.8 1.0 1 0 0 1 1 1 1 Solute carrier family 35 CRT-like PF08627.10 EMD63397.1 - 3.4e-10 39.4 5.4 5.4e-10 38.7 5.4 1.2 1 0 0 1 1 1 1 CRT-like, chloroquine-resistance transporter-like EamA PF00892.20 EMD63397.1 - 0.00078 19.6 37.3 0.022 14.9 14.8 2.3 2 1 0 2 2 2 2 EamA-like transporter family HCV_env PF01539.17 EMD63397.1 - 0.05 13.3 1.9 0.097 12.3 1.9 1.5 1 0 0 1 1 1 0 Hepatitis C virus envelope glycoprotein E1 FUSC-like PF12805.7 EMD63397.1 - 0.72 8.9 6.6 0.42 9.7 1.3 2.7 2 1 0 2 2 2 0 FUSC-like inner membrane protein yccS Pro-rich PF15240.6 EMD63398.1 - 1.7 8.9 43.7 3.7 7.8 43.7 1.5 1 0 0 1 1 1 0 Proline-rich zf-RING_2 PF13639.6 EMD63399.1 - 2.7e-08 34.0 1.3 2.7e-08 34.0 1.3 3.4 3 1 0 3 3 3 1 Ring finger domain zf-rbx1 PF12678.7 EMD63399.1 - 7.8e-07 29.3 1.4 7.8e-07 29.3 1.4 2.1 2 0 0 2 2 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 EMD63399.1 - 4.9e-06 26.3 1.4 4.9e-06 26.3 1.4 3.1 4 0 0 4 4 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMD63399.1 - 8.6e-06 25.5 0.6 8.6e-06 25.5 0.6 2.6 4 0 0 4 4 3 1 Zinc finger, C3HC4 type (RING finger) PHD PF00628.29 EMD63399.1 - 6.1e-05 22.8 18.5 9.9e-05 22.2 10.2 2.6 2 0 0 2 2 2 1 PHD-finger Prok-RING_4 PF14447.6 EMD63399.1 - 0.00011 22.0 1.0 0.00011 22.0 1.0 2.3 2 0 0 2 2 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EMD63399.1 - 0.00024 21.0 0.2 0.00024 21.0 0.2 3.1 3 1 1 4 4 3 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EMD63399.1 - 0.00034 20.4 0.5 0.00034 20.4 0.5 3.3 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) PHD_2 PF13831.6 EMD63399.1 - 0.0024 17.4 6.9 0.0024 17.4 6.9 1.7 2 0 0 2 2 1 1 PHD-finger zf-ANAPC11 PF12861.7 EMD63399.1 - 0.015 15.3 0.3 0.015 15.3 0.3 2.4 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger zinc_ribbon_16 PF17034.5 EMD63399.1 - 0.034 14.4 0.1 0.034 14.4 0.1 1.8 2 0 0 2 2 1 0 Zinc-ribbon like family zf-RING_4 PF14570.6 EMD63399.1 - 0.098 12.5 0.1 0.098 12.5 0.1 2.5 2 0 0 2 2 1 0 RING/Ubox like zinc-binding domain UxaC PF02614.14 EMD63399.1 - 0.2 10.5 0.0 0.29 9.9 0.0 1.1 1 0 0 1 1 1 0 Glucuronate isomerase Zn_ribbon_17 PF17120.5 EMD63399.1 - 0.55 9.9 12.5 0.12 12.1 1.0 2.5 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type C1_1 PF00130.22 EMD63399.1 - 3.3 7.7 13.4 0.038 13.9 3.9 2.5 2 1 1 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Sacchrp_dh_NADP PF03435.18 EMD63400.1 - 1.1e-16 61.3 0.0 1.7e-16 60.7 0.0 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Semialdhyde_dh PF01118.24 EMD63400.1 - 0.15 12.5 0.0 0.3 11.5 0.0 1.5 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain Med22 PF06179.12 EMD63401.1 - 3.5e-06 27.2 0.2 5.6e-06 26.5 0.2 1.4 1 0 0 1 1 1 1 Surfeit locus protein 5 subunit 22 of Mediator complex Sec3_C PF09763.9 EMD63402.1 - 0.88 7.9 4.3 0.98 7.7 4.3 1.4 1 0 0 1 1 1 0 Exocyst complex component Sec3 DUF5477 PF17571.2 EMD63403.1 - 0.01 16.0 2.5 0.027 14.6 2.5 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5477) SMK-1 PF04802.15 EMD63404.1 - 1.1e-78 263.5 3.1 1.1e-78 263.5 3.1 2.1 2 0 0 2 2 2 1 Component of IIS longevity pathway SMK-1 DUF1299 PF06975.11 EMD63404.1 - 0.063 13.4 1.2 0.23 11.5 1.2 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1299) DUF4704 PF15787.5 EMD63404.1 - 0.094 11.9 2.7 0.06 12.6 0.5 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4704) DHFR_1 PF00186.19 EMD63405.1 - 4.9e-25 88.1 0.0 5.3e-24 84.7 0.0 2.4 1 1 0 1 1 1 1 Dihydrofolate reductase MAPEG PF01124.18 EMD63406.1 - 3.8e-17 62.4 4.6 4.4e-17 62.2 4.6 1.1 1 0 0 1 1 1 1 MAPEG family Lipase_3 PF01764.25 EMD63407.1 - 4.7e-21 75.2 0.0 8.2e-21 74.4 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_6 PF12697.7 EMD63407.1 - 0.012 16.3 0.6 0.08 13.5 0.0 2.2 2 0 0 2 2 2 0 Alpha/beta hydrolase family 1-cysPrx_C PF10417.9 EMD63407.1 - 0.11 12.4 0.0 0.29 11.0 0.0 1.6 1 0 0 1 1 1 0 C-terminal domain of 1-Cys peroxiredoxin PGAP1 PF07819.13 EMD63407.1 - 0.18 11.5 0.0 0.39 10.4 0.0 1.5 1 0 0 1 1 1 0 PGAP1-like protein Voltage_CLC PF00654.20 EMD63409.1 - 7.4e-89 298.4 29.1 1.3e-88 297.7 29.1 1.4 1 0 0 1 1 1 1 Voltage gated chloride channel ADH_N PF08240.12 EMD63409.1 - 4.6e-25 87.6 2.2 9.9e-25 86.6 2.2 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EMD63409.1 - 2.3e-17 63.2 0.4 5.3e-17 62.0 0.4 1.7 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EMD63409.1 - 1.5e-05 26.1 0.0 3.2e-05 25.0 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase CBS PF00571.28 EMD63409.1 - 5.8e-05 23.5 0.0 0.027 14.9 0.0 3.3 3 0 0 3 3 3 1 CBS domain peroxidase PF00141.23 EMD63410.1 - 8.4e-83 277.6 0.0 1.6e-41 142.5 0.0 2.5 2 1 0 2 2 2 2 Peroxidase AMPK1_CBM PF16561.5 EMD63411.1 - 7.3e-06 26.1 0.0 1.3e-05 25.3 0.0 1.4 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase Peptidase_M48 PF01435.18 EMD63414.1 - 1.7e-33 116.1 0.0 6.1e-33 114.3 0.0 1.9 1 1 0 1 1 1 1 Peptidase family M48 Cutinase PF01083.22 EMD63415.1 - 6.6e-26 91.3 0.8 1.1e-25 90.6 0.8 1.4 1 0 0 1 1 1 1 Cutinase DUF3500 PF12006.8 EMD63416.1 - 2.3e-106 355.6 0.0 2.8e-106 355.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3500) FAD_binding_3 PF01494.19 EMD63417.1 - 1.8e-16 60.4 0.0 1.1e-15 57.7 0.0 2.0 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 EMD63417.1 - 2e-07 31.2 0.3 4.4e-07 30.0 0.3 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EMD63417.1 - 3e-07 30.0 0.5 0.00046 19.5 1.1 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EMD63417.1 - 2.7e-06 27.2 1.9 0.00057 19.6 1.7 2.5 2 1 1 3 3 3 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EMD63417.1 - 6e-05 22.3 3.3 0.00011 21.5 2.5 1.8 2 0 0 2 2 2 1 FAD binding domain ThiF PF00899.21 EMD63417.1 - 0.0035 16.7 0.1 0.0065 15.9 0.1 1.4 1 0 0 1 1 1 1 ThiF family Pyr_redox PF00070.27 EMD63417.1 - 0.01 16.4 0.1 0.05 14.2 0.2 2.2 3 0 0 3 3 2 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EMD63417.1 - 0.012 14.7 1.1 0.016 14.3 1.1 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A Trp_halogenase PF04820.14 EMD63417.1 - 0.013 14.4 0.4 0.018 13.9 0.4 1.2 1 0 0 1 1 1 0 Tryptophan halogenase Thi4 PF01946.17 EMD63417.1 - 0.024 13.9 0.4 0.04 13.1 0.4 1.3 1 0 0 1 1 1 0 Thi4 family Pyr_redox_3 PF13738.6 EMD63417.1 - 0.024 13.9 1.3 0.035 13.4 1.3 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase MCRA PF06100.11 EMD63417.1 - 0.078 11.8 0.6 0.13 11.1 0.6 1.3 1 0 0 1 1 1 0 MCRA family FAD_oxidored PF12831.7 EMD63417.1 - 0.11 11.9 2.7 0.18 11.1 2.7 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EMD63417.1 - 0.13 12.2 1.0 0.43 10.6 0.4 2.0 2 0 0 2 2 2 0 FAD-NAD(P)-binding HI0933_like PF03486.14 EMD63417.1 - 0.37 9.4 1.4 0.65 8.6 1.4 1.3 1 0 0 1 1 1 0 HI0933-like protein MFS_1 PF07690.16 EMD63418.1 - 3.2e-40 138.1 23.5 4.9e-40 137.5 23.5 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EMD63418.1 - 9.2e-10 38.0 6.9 9.2e-10 38.0 6.9 2.5 3 0 0 3 3 3 1 Sugar (and other) transporter RF-1 PF00472.20 EMD63419.1 - 0.0061 16.5 0.5 0.0096 15.9 0.5 1.2 1 0 0 1 1 1 1 RF-1 domain AMP-binding PF00501.28 EMD63419.1 - 0.016 13.8 0.0 0.018 13.7 0.0 1.1 1 0 0 1 1 1 0 AMP-binding enzyme Chlamy_scaf PF09675.10 EMD63419.1 - 0.071 13.5 0.1 1.6 9.1 0.0 2.3 1 1 1 2 2 2 0 Chlamydia-phage Chp2 scaffold (Chlamy_scaf) UIM PF02809.20 EMD63419.1 - 4 7.6 6.2 5.9 7.0 0.4 3.0 3 0 0 3 3 3 0 Ubiquitin interaction motif AA_permease PF00324.21 EMD63420.1 - 2.6e-42 145.0 33.8 4.5e-41 140.9 33.8 2.3 1 1 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EMD63420.1 - 6.4e-22 78.0 23.2 8.1e-22 77.6 23.2 1.1 1 0 0 1 1 1 1 Amino acid permease Ubiq_cyt_C_chap PF03981.12 EMD63422.1 - 1.5e-34 119.1 1.3 2.2e-34 118.6 1.3 1.2 1 0 0 1 1 1 1 Ubiquinol-cytochrome C chaperone Arrestin_C PF02752.22 EMD63423.1 - 0.0068 16.9 0.0 2.3 8.6 0.0 2.8 2 1 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain DDHD PF02862.17 EMD63423.1 - 0.057 13.6 0.1 0.091 12.9 0.1 1.2 1 0 0 1 1 1 0 DDHD domain mRNA_cap_enzyme PF01331.19 EMD63424.1 - 9.6e-47 159.3 0.0 1.6e-46 158.6 0.0 1.4 1 0 0 1 1 1 1 mRNA capping enzyme, catalytic domain mRNA_cap_C PF03919.15 EMD63424.1 - 5.9e-29 100.9 0.0 9.2e-29 100.3 0.0 1.3 1 0 0 1 1 1 1 mRNA capping enzyme, C-terminal domain DNA_ligase_A_M PF01068.21 EMD63424.1 - 4.1e-06 26.6 0.0 0.0001 22.0 0.0 2.6 1 1 1 2 2 2 1 ATP dependent DNA ligase domain PHF5 PF03660.14 EMD63425.1 - 2.1e-51 172.5 10.5 2.4e-51 172.3 10.5 1.0 1 0 0 1 1 1 1 PHF5-like protein PolC_DP2 PF03833.13 EMD63425.1 - 0.39 8.5 7.3 0.37 8.6 6.8 1.2 1 1 0 1 1 1 0 DNA polymerase II large subunit DP2 DZR PF12773.7 EMD63425.1 - 2.9 8.0 16.5 5.5 7.1 2.0 3.0 1 1 1 2 2 2 0 Double zinc ribbon Pinin_SDK_memA PF04696.13 EMD63426.1 - 3.5e-29 101.5 16.5 3.5e-29 101.5 16.5 2.4 2 1 0 2 2 2 1 pinin/SDK/memA/ protein conserved region Abhydrolase_1 PF00561.20 EMD63427.1 - 3.3e-23 82.7 0.0 1.9e-15 57.3 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EMD63427.1 - 8.7e-14 52.6 0.0 1.1e-13 52.3 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EMD63427.1 - 1.1e-07 31.4 0.0 2.7e-06 26.9 0.0 2.0 2 0 0 2 2 2 1 Serine aminopeptidase, S33 ADH_N PF08240.12 EMD63428.1 - 9e-27 93.1 0.4 1.9e-26 92.0 0.4 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EMD63428.1 - 8e-16 58.2 0.6 1.6e-15 57.2 0.6 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EMD63428.1 - 7.2e-09 35.4 0.1 0.00089 18.8 0.1 2.4 2 1 0 2 2 2 2 Glucose dehydrogenase C-terminus AlaDh_PNT_C PF01262.21 EMD63428.1 - 0.018 14.3 1.0 0.033 13.5 1.0 1.5 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain UDPG_MGDP_dh_N PF03721.14 EMD63428.1 - 0.046 13.3 0.3 0.091 12.3 0.3 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain DUF281 PF03436.13 EMD63428.1 - 0.096 13.1 0.2 1.5 9.3 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF281) MTS PF05175.14 EMD63428.1 - 0.14 11.7 0.2 0.3 10.6 0.2 1.5 1 0 0 1 1 1 0 Methyltransferase small domain MitMem_reg PF13012.6 EMD63429.1 - 4.2e-10 40.0 0.2 1e-09 38.8 0.2 1.7 1 1 0 1 1 1 1 Maintenance of mitochondrial structure and function JAB PF01398.21 EMD63429.1 - 1e-08 35.2 0.0 2.2e-08 34.1 0.0 1.5 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease FMO-like PF00743.19 EMD63433.1 - 1.2e-18 66.8 0.0 2.6e-16 59.1 0.0 2.8 2 1 0 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EMD63433.1 - 2.5e-16 59.8 0.5 3.2e-13 49.6 0.0 3.8 3 1 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EMD63433.1 - 8.3e-13 48.2 0.6 9.3e-09 34.9 0.0 3.8 4 0 0 4 4 4 2 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.14 EMD63433.1 - 8.5e-12 44.9 0.0 6.5e-08 32.1 0.0 3.2 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EMD63433.1 - 1.2e-07 31.7 0.0 3.4e-06 26.9 0.0 2.6 3 0 0 3 3 3 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EMD63433.1 - 1.5e-07 31.6 0.0 3.8e-07 30.2 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 EMD63433.1 - 4.9e-06 26.6 0.7 0.0092 16.0 0.0 4.0 4 1 0 4 4 4 1 FAD-NAD(P)-binding FAD_binding_2 PF00890.24 EMD63433.1 - 0.00027 20.1 0.1 0.0005 19.3 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain Shikimate_DH PF01488.20 EMD63433.1 - 0.0032 17.5 0.0 1.3 9.1 0.0 2.4 2 0 0 2 2 2 2 Shikimate / quinate 5-dehydrogenase Lycopene_cycl PF05834.12 EMD63433.1 - 0.0079 15.3 0.0 0.016 14.3 0.0 1.5 1 0 0 1 1 1 1 Lycopene cyclase protein Thi4 PF01946.17 EMD63433.1 - 0.012 14.8 0.1 0.023 13.9 0.1 1.4 1 0 0 1 1 1 0 Thi4 family NAD_binding_7 PF13241.6 EMD63433.1 - 0.15 12.5 0.0 1.2 9.6 0.0 2.3 2 0 0 2 2 2 0 Putative NAD(P)-binding HI0933_like PF03486.14 EMD63433.1 - 0.21 10.3 0.9 0.47 9.1 0.9 1.6 1 0 0 1 1 1 0 HI0933-like protein DUF3445 PF11927.8 EMD63434.1 - 8.2e-76 254.6 0.0 1.2e-75 254.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3445) NmrA PF05368.13 EMD63435.1 - 7.7e-33 114.0 0.0 1.3e-32 113.2 0.0 1.5 1 1 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EMD63435.1 - 5.5e-11 42.7 0.0 7.7e-11 42.2 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EMD63435.1 - 0.0078 15.7 0.0 0.011 15.2 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family TrkA_N PF02254.18 EMD63435.1 - 0.0097 16.2 0.0 0.02 15.1 0.0 1.5 1 0 0 1 1 1 1 TrkA-N domain Bacillus_HBL PF05791.11 EMD63435.1 - 0.22 11.3 0.7 2.2 8.1 0.1 2.1 1 1 1 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) Glyco_hydro_47 PF01532.20 EMD63436.1 - 3.5e-181 603.1 0.0 4.1e-181 602.9 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Med20 PF08612.11 EMD63437.1 - 6.7e-13 48.5 0.1 1.1e-12 47.8 0.1 1.3 1 1 0 1 1 1 1 TATA-binding related factor (TRF) of subunit 20 of Mediator complex MFMR PF07777.11 EMD63437.1 - 0.04 14.4 3.8 0.082 13.4 3.8 1.5 1 0 0 1 1 1 0 G-box binding protein MFMR Pur_ac_phosph_N PF16656.5 EMD63437.1 - 0.085 13.4 0.1 0.17 12.4 0.1 1.5 1 0 0 1 1 1 0 Purple acid Phosphatase, N-terminal domain RRM_1 PF00076.22 EMD63438.1 - 1.4e-39 133.8 0.0 3.9e-12 45.8 0.0 4.4 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EMD63438.1 - 1e-13 50.9 0.0 0.0054 16.6 0.0 4.4 4 0 0 4 4 4 4 Occluded RNA-recognition motif RRM PF10378.9 EMD63438.1 - 2.7e-08 33.4 8.4 2.7e-08 33.4 8.4 4.8 4 2 1 5 5 5 1 Putative RRM domain RRM_7 PF16367.5 EMD63438.1 - 5.6e-06 26.4 0.3 0.0092 16.1 0.0 3.7 4 0 0 4 4 4 2 RNA recognition motif DUF4523 PF15023.6 EMD63438.1 - 1.8e-05 24.6 0.0 0.099 12.5 0.0 3.2 3 0 0 3 3 3 2 Protein of unknown function (DUF4523) RRM_3 PF08777.11 EMD63438.1 - 0.0096 16.0 3.4 0.63 10.1 0.1 3.3 4 0 0 4 4 4 1 RNA binding motif RNA_bind PF08675.11 EMD63438.1 - 0.16 12.0 0.2 0.91 9.6 0.0 2.4 3 0 0 3 3 3 0 RNA binding domain Alg6_Alg8 PF03155.15 EMD63439.1 - 5.6e-169 563.2 26.2 7.5e-169 562.7 26.2 1.1 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family WAC_Acf1_DNA_bd PF10537.9 EMD63439.1 - 4.9e-38 129.7 1.6 4.9e-38 129.7 1.6 2.8 2 0 0 2 2 2 1 ATP-utilising chromatin assembly and remodelling N-terminal WSD PF15613.6 EMD63439.1 - 1.7e-20 73.3 0.1 1.7e-20 73.3 0.1 3.0 3 0 0 3 3 3 1 Williams-Beuren syndrome DDT (WSD), D-TOX E motif DDT PF02791.17 EMD63439.1 - 7.9e-15 54.9 1.0 2e-14 53.6 1.0 1.8 1 0 0 1 1 1 1 DDT domain DUF5097 PF17020.5 EMD63439.1 - 0.0025 18.2 0.1 0.007 16.7 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF5097) GAGA_bind PF06217.12 EMD63439.1 - 7.5 6.7 19.1 3.3 7.9 11.1 2.5 2 0 0 2 2 2 0 GAGA binding protein-like family SCA7 PF08313.12 EMD63440.1 - 8.6e-31 105.7 0.2 8.6e-31 105.7 0.2 1.8 2 0 0 2 2 2 1 SCA7, zinc-binding domain CDC45 PF02724.14 EMD63440.1 - 0.17 10.1 5.4 0.23 9.7 5.4 1.1 1 0 0 1 1 1 0 CDC45-like protein Sgf11 PF08209.11 EMD63440.1 - 0.22 11.1 1.5 0.38 10.4 1.5 1.4 1 0 0 1 1 1 0 Sgf11 (transcriptional regulation protein) Hexokinase_2 PF03727.16 EMD63441.1 - 1.6e-83 279.8 0.0 4.4e-83 278.4 0.0 1.6 2 0 0 2 2 2 1 Hexokinase Hexokinase_1 PF00349.21 EMD63441.1 - 4.8e-72 242.0 0.0 7.2e-72 241.5 0.0 1.3 1 0 0 1 1 1 1 Hexokinase adh_short PF00106.25 EMD63442.1 - 2.7e-23 82.5 0.0 5.8e-21 74.8 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EMD63442.1 - 5e-11 42.6 0.0 1.5e-10 41.1 0.0 1.7 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 EMD63442.1 - 3.9e-06 26.5 0.0 7.6e-06 25.6 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family KR PF08659.10 EMD63442.1 - 0.00022 21.2 0.0 0.00029 20.8 0.0 1.3 1 0 0 1 1 1 1 KR domain GDP_Man_Dehyd PF16363.5 EMD63442.1 - 0.014 14.9 0.0 0.059 12.8 0.0 1.8 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase Cyclase PF04199.13 EMD63444.1 - 1.1e-12 48.4 0.0 2.4e-12 47.2 0.0 1.5 1 1 1 2 2 2 1 Putative cyclase RabGAP-TBC PF00566.18 EMD63445.1 - 5e-50 170.1 0.0 4.8e-48 163.7 0.0 2.2 2 0 0 2 2 2 2 Rab-GTPase-TBC domain DUF3220 PF11516.8 EMD63445.1 - 0.037 14.3 1.1 1.1 9.5 0.0 3.7 5 0 0 5 5 5 0 Protein of unknown function (DUF3120) RRM_1 PF00076.22 EMD63446.1 - 2.3e-31 107.4 0.2 4.4e-15 55.3 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EMD63446.1 - 8.7e-11 41.8 0.1 0.00051 20.1 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif Nup35_RRM_2 PF14605.6 EMD63446.1 - 0.031 14.3 0.0 4.6 7.3 0.0 2.3 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 EMD63446.1 - 0.099 12.7 0.0 10 6.3 0.0 2.5 2 0 0 2 2 2 0 RNA binding motif TMEM156 PF15106.6 EMD63446.1 - 0.15 11.5 0.0 0.24 10.8 0.0 1.2 1 0 0 1 1 1 0 TMEM156 protein family Glyco_hydro_16 PF00722.21 EMD63448.1 - 8.3e-44 149.2 1.1 1.4e-43 148.4 1.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 DUF4115 PF13464.6 EMD63448.1 - 0.079 13.2 0.6 0.36 11.1 0.1 2.3 3 1 0 3 3 3 0 Domain of unknown function (DUF4115) Aldedh PF00171.22 EMD63449.1 - 2.5e-11 42.8 5.2 5.2e-06 25.2 2.2 2.6 2 1 0 2 2 2 2 Aldehyde dehydrogenase family URO-D PF01208.17 EMD63449.1 - 0.15 11.2 0.0 0.26 10.4 0.0 1.4 1 1 0 1 1 1 0 Uroporphyrinogen decarboxylase (URO-D) Amino_oxidase PF01593.24 EMD63450.1 - 3.2e-09 36.6 0.0 8.9e-09 35.1 0.0 1.6 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EMD63450.1 - 1.1e-08 35.2 0.0 3.4e-08 33.6 0.0 1.9 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EMD63450.1 - 0.00015 21.2 0.1 0.017 14.4 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EMD63450.1 - 0.0065 16.1 0.1 0.048 13.2 0.0 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.17 EMD63450.1 - 0.0083 15.4 0.1 0.018 14.3 0.1 1.5 1 0 0 1 1 1 1 Thi4 family FAD_binding_3 PF01494.19 EMD63450.1 - 0.0093 15.2 0.1 0.016 14.5 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.6 EMD63450.1 - 0.011 15.0 1.0 0.016 14.5 0.1 1.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EMD63450.1 - 0.038 12.7 0.1 0.15 10.8 0.0 1.8 2 0 0 2 2 2 0 HI0933-like protein FAD_oxidored PF12831.7 EMD63450.1 - 0.054 12.8 0.0 0.081 12.3 0.0 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 EMD63450.1 - 0.073 12.1 0.7 0.1 11.6 0.1 1.5 2 0 0 2 2 2 0 Lycopene cyclase protein NAD_binding_9 PF13454.6 EMD63450.1 - 0.075 13.0 0.2 0.7 9.9 0.0 2.5 3 0 0 3 3 3 0 FAD-NAD(P)-binding TrkA_N PF02254.18 EMD63450.1 - 0.088 13.1 0.1 0.33 11.2 0.0 2.0 2 0 0 2 2 2 0 TrkA-N domain TPT PF03151.16 EMD63451.1 - 1.3e-25 90.3 21.7 1.8e-25 89.9 21.7 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family UAA PF08449.11 EMD63451.1 - 0.0016 17.7 20.9 0.005 16.1 3.7 2.1 2 0 0 2 2 2 2 UAA transporter family EamA PF00892.20 EMD63451.1 - 0.0026 17.9 12.9 0.0026 17.9 12.9 2.5 3 0 0 3 3 3 2 EamA-like transporter family Ribosomal_L18 PF17135.4 EMD63452.1 - 4.6e-64 215.3 0.5 5e-64 215.1 0.5 1.0 1 0 0 1 1 1 1 Ribosomal protein 60S L18 and 50S L18e Ribosomal_L27A PF00828.19 EMD63452.1 - 0.00021 22.0 0.1 0.00045 20.9 0.1 1.7 1 1 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A AIRC PF00731.20 EMD63453.1 - 4.4e-57 191.8 0.0 1.3e-56 190.3 0.0 1.8 1 0 0 1 1 1 1 AIR carboxylase ATP-grasp PF02222.22 EMD63453.1 - 9.2e-54 181.6 0.0 1.7e-53 180.7 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain PurK_C PF17769.1 EMD63453.1 - 6.1e-19 67.5 0.0 1.5e-18 66.2 0.0 1.7 1 0 0 1 1 1 1 Phosphoribosylaminoimidazole carboxylase C-terminal domain AlaDh_PNT_C PF01262.21 EMD63453.1 - 5.8e-05 22.5 1.5 0.0001 21.7 1.5 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain CPSase_L_D2 PF02786.17 EMD63453.1 - 7.9e-05 22.3 0.0 0.00016 21.2 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Dala_Dala_lig_C PF07478.13 EMD63453.1 - 0.00018 21.1 0.0 0.00048 19.7 0.0 1.8 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus 2-Hacid_dh_C PF02826.19 EMD63453.1 - 0.003 16.9 0.1 0.0053 16.1 0.1 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.18 EMD63453.1 - 0.0081 16.1 0.6 0.017 15.0 0.6 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain XdhC_C PF13478.6 EMD63453.1 - 0.013 16.0 0.3 0.38 11.3 0.1 2.5 2 0 0 2 2 2 0 XdhC Rossmann domain NAD_binding_2 PF03446.15 EMD63453.1 - 0.018 15.2 0.2 0.04 14.1 0.2 1.6 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase ATP-grasp_3 PF02655.14 EMD63453.1 - 0.028 14.4 0.0 0.074 13.1 0.0 1.8 1 1 0 1 1 1 0 ATP-grasp domain BsuPI PF12690.7 EMD63454.1 - 0.046 13.8 0.0 0.094 12.8 0.0 1.5 1 0 0 1 1 1 0 Intracellular proteinase inhibitor GMC_oxred_C PF05199.13 EMD63455.1 - 4.8e-24 85.5 0.0 5.5e-24 85.3 0.0 1.0 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_N PF00732.19 EMD63456.1 - 1.7e-37 129.4 0.0 3.2e-37 128.5 0.0 1.4 1 1 0 1 1 1 1 GMC oxidoreductase Lycopene_cycl PF05834.12 EMD63456.1 - 0.00072 18.7 0.0 0.0011 18.1 0.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein NAD_binding_8 PF13450.6 EMD63456.1 - 0.0017 18.6 0.0 0.0058 16.8 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EMD63456.1 - 0.018 14.7 0.0 0.027 14.0 0.0 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase HTH_51 PF18558.1 EMD63456.1 - 0.18 11.7 0.0 0.35 10.8 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain Glyco_transf_34 PF05637.12 EMD63457.1 - 1.3e-12 48.0 0.0 1.9e-11 44.2 0.0 2.0 1 1 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family HeLo PF14479.6 EMD63458.1 - 6.4e-09 36.0 0.5 0.0014 18.5 0.0 2.9 3 0 0 3 3 3 2 Prion-inhibition and propagation Pkinase PF00069.25 EMD63458.1 - 0.00026 20.4 0.0 0.00052 19.5 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD63458.1 - 0.043 13.1 0.0 0.1 11.9 0.0 1.5 1 0 0 1 1 1 0 Protein tyrosine kinase IQ PF00612.27 EMD63458.1 - 4.7 7.3 5.2 38 4.5 1.2 2.7 2 0 0 2 2 2 0 IQ calmodulin-binding motif SNase PF00565.17 EMD63459.1 - 3.2e-72 239.9 0.6 8.9e-26 90.5 0.0 5.6 5 0 0 5 5 5 5 Staphylococcal nuclease homologue TUDOR PF00567.24 EMD63459.1 - 9.1e-26 90.3 0.0 1.8e-25 89.3 0.0 1.5 1 0 0 1 1 1 1 Tudor domain Agenet PF05641.12 EMD63459.1 - 0.0073 16.8 0.5 0.059 13.8 0.2 2.8 3 0 0 3 3 3 1 Agenet domain adh_short PF00106.25 EMD63460.1 - 0.0072 15.8 0.0 0.047 13.2 0.0 2.0 2 0 0 2 2 2 1 short chain dehydrogenase SLT_L PF14718.6 EMD63460.1 - 0.19 11.9 1.6 0.37 10.9 0.1 2.0 2 0 0 2 2 2 0 Soluble lytic murein transglycosylase L domain Glyco_hydro_17 PF00332.18 EMD63462.1 - 5.4e-09 36.1 3.0 6.2e-06 26.0 1.5 2.3 1 1 1 2 2 2 2 Glycosyl hydrolases family 17 Shadoo PF14999.6 EMD63462.1 - 0.27 11.3 18.8 0.14 12.2 15.8 2.1 1 1 1 2 2 2 0 Shadow of prion protein, neuroprotective Ferritin_2 PF13668.6 EMD63463.1 - 1.9e-44 151.1 6.4 2.8e-44 150.6 6.4 1.2 1 0 0 1 1 1 1 Ferritin-like domain HTH_psq PF05225.16 EMD63465.1 - 1.8e-07 30.8 0.1 2.6e-07 30.3 0.1 1.2 1 0 0 1 1 1 1 helix-turn-helix, Psq domain CENP-B_N PF04218.13 EMD63465.1 - 0.052 13.2 0.0 0.087 12.5 0.0 1.3 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain SpoIIID PF12116.8 EMD63465.1 - 0.063 13.4 0.0 0.069 13.3 0.0 1.2 1 0 0 1 1 1 0 Stage III sporulation protein D OTT_1508_deam PF14441.6 EMD63466.1 - 5.3e-20 71.2 0.9 1.1e-19 70.2 0.9 1.6 1 0 0 1 1 1 1 OTT_1508-like deaminase NAD_binding_6 PF08030.12 EMD63468.1 - 0.011 15.8 0.3 0.053 13.6 0.0 2.1 2 0 0 2 2 2 0 Ferric reductase NAD binding domain NAD_binding_1 PF00175.21 EMD63468.1 - 0.11 13.1 0.1 0.34 11.6 0.1 1.7 1 1 0 1 1 1 0 Oxidoreductase NAD-binding domain TMEM190 PF15431.6 EMD63468.1 - 1.1 9.5 3.4 0.57 10.3 0.3 2.0 2 0 0 2 2 2 0 Transmembrane protein 190 Abhydrolase_1 PF00561.20 EMD63469.1 - 2.6e-25 89.6 0.2 1e-24 87.6 0.2 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EMD63469.1 - 1.8e-20 74.5 1.2 1.4e-19 71.6 1.2 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EMD63469.1 - 1.8e-14 53.6 0.0 3e-14 52.9 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 EMD63469.1 - 0.00022 20.7 0.4 0.0005 19.6 0.1 1.6 2 0 0 2 2 2 1 Prolyl oligopeptidase family Esterase PF00756.20 EMD63469.1 - 0.00042 20.0 0.0 0.00066 19.4 0.0 1.5 1 1 0 1 1 1 1 Putative esterase Antimicrobial14 PF08109.11 EMD63469.1 - 0.17 11.9 0.7 0.42 10.7 0.0 2.0 2 0 0 2 2 2 0 Lactocin 705 family DUF3669 PF12417.8 EMD63470.1 - 4.9e-19 68.3 0.6 9e-19 67.5 0.6 1.5 1 0 0 1 1 1 1 Zinc finger protein DUF1100 PF06500.11 EMD63472.1 - 4.5e-13 48.8 0.0 7.2e-13 48.1 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1100) Esterase PF00756.20 EMD63472.1 - 0.00027 20.6 0.0 0.0073 16.0 0.0 2.7 1 1 1 2 2 2 1 Putative esterase Hydrolase_4 PF12146.8 EMD63472.1 - 0.00095 18.5 0.0 0.0024 17.2 0.0 1.6 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EMD63472.1 - 0.001 18.7 0.1 0.18 11.4 0.3 2.3 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 EMD63472.1 - 0.019 14.8 0.0 0.033 14.0 0.0 1.3 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase tRNA-synt_2 PF00152.20 EMD63473.1 - 2.8e-81 273.0 2.0 3.8e-81 272.6 2.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA-synt_2d PF01409.20 EMD63473.1 - 2.7e-06 27.1 0.2 0.0041 16.6 0.1 2.3 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) tRNA_anti-codon PF01336.25 EMD63473.1 - 5.6e-06 26.3 0.0 1.6e-05 24.8 0.0 1.8 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain Hemerythrin PF01814.23 EMD63473.1 - 0.1 13.2 0.1 11 6.6 0.0 2.7 2 0 0 2 2 2 0 Hemerythrin HHE cation binding domain Coilin_N PF15862.5 EMD63473.1 - 6.4 6.6 9.6 13 5.6 9.6 1.5 1 0 0 1 1 1 0 Coilin N-terminus Pkinase PF00069.25 EMD63474.1 - 3.5e-40 138.0 0.0 5.2e-40 137.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD63474.1 - 4.9e-22 78.5 0.0 1.9e-21 76.6 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase SGL PF08450.12 EMD63475.1 - 3.4e-23 82.5 0.6 6.3e-23 81.6 0.6 1.5 1 1 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Str_synth PF03088.16 EMD63475.1 - 1.6e-05 24.9 0.0 7.5e-05 22.8 0.0 2.1 1 1 0 1 1 1 1 Strictosidine synthase Arylesterase PF01731.20 EMD63475.1 - 0.00011 22.3 0.4 0.00046 20.3 0.1 2.3 2 1 0 2 2 2 1 Arylesterase PD40 PF07676.12 EMD63475.1 - 0.0056 16.6 0.1 0.3 11.1 0.0 2.9 2 0 0 2 2 2 1 WD40-like Beta Propeller Repeat NHL PF01436.21 EMD63475.1 - 0.077 13.1 1.7 5.1 7.3 0.0 3.5 3 0 0 3 3 3 0 NHL repeat Pkinase PF00069.25 EMD63480.1 - 2.2e-06 27.3 0.0 4.4e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.14 EMD63480.1 - 0.0011 18.4 0.0 0.0019 17.6 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EMD63480.1 - 0.0046 16.9 1.0 0.034 14.1 0.0 2.6 3 1 1 4 4 4 1 Phosphotransferase enzyme family WaaY PF06176.11 EMD63480.1 - 0.023 14.3 0.0 0.046 13.3 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) UPF0524 PF15823.5 EMD63480.1 - 0.061 12.7 2.1 0.11 11.9 2.1 1.3 1 0 0 1 1 1 0 UPF0524 of C3orf70 zf-C2H2 PF00096.26 EMD63481.1 - 8.1e-12 44.9 14.6 2.2e-05 24.6 4.1 4.1 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMD63481.1 - 4.5e-08 33.2 7.5 0.0016 18.7 0.1 3.2 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMD63481.1 - 1.3e-06 28.8 11.8 0.025 15.4 3.6 4.1 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_11 PF16622.5 EMD63481.1 - 0.0016 18.1 5.7 0.14 12.0 2.3 2.5 2 0 0 2 2 2 2 zinc-finger C2H2-type zf-C2H2_8 PF15909.5 EMD63481.1 - 0.076 13.3 1.1 0.28 11.5 0.3 2.4 2 0 0 2 2 2 0 C2H2-type zinc ribbon zf-C2H2_6 PF13912.6 EMD63481.1 - 3.5 7.7 9.7 5.1 7.2 0.1 3.4 3 0 0 3 3 3 0 C2H2-type zinc finger zf-BED PF02892.15 EMD63481.1 - 4.4 7.4 6.2 96 3.1 6.2 2.5 1 1 0 1 1 1 0 BED zinc finger ubiquitin PF00240.23 EMD63482.1 - 1.7e-34 117.4 0.4 2.9e-34 116.6 0.4 1.4 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_S27 PF01599.19 EMD63482.1 - 4.2e-27 94.0 2.3 4.2e-27 94.0 2.3 1.9 2 0 0 2 2 2 1 Ribosomal protein S27a Rad60-SLD PF11976.8 EMD63482.1 - 1.4e-16 60.0 0.6 2.7e-16 59.2 0.6 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EMD63482.1 - 4.1e-05 23.9 0.2 0.0002 21.8 0.1 2.1 2 1 0 2 2 2 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 EMD63482.1 - 0.0013 18.8 0.5 0.0029 17.7 0.5 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like TBK1_ULD PF18396.1 EMD63482.1 - 0.0073 16.2 0.0 0.011 15.6 0.0 1.3 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_5 PF18037.1 EMD63482.1 - 0.0096 16.3 0.9 0.016 15.6 0.0 1.7 1 1 1 2 2 2 1 Ubiquitin-like domain DUF2407 PF10302.9 EMD63482.1 - 0.011 16.3 0.7 0.016 15.8 0.7 1.2 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain IBR PF01485.21 EMD63482.1 - 0.028 14.6 0.3 0.048 13.9 0.3 1.4 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain Ubiquitin_4 PF18036.1 EMD63482.1 - 0.031 14.3 1.0 5.6 7.1 0.2 2.4 2 0 0 2 2 2 0 Ubiquitin-like domain Band_7 PF01145.25 EMD63483.1 - 2.7e-21 76.4 5.6 4.7e-21 75.6 5.6 1.4 1 1 0 1 1 1 1 SPFH domain / Band 7 family Lectin_leg-like PF03388.13 EMD63484.1 - 3.5e-31 108.3 0.0 5.3e-31 107.7 0.0 1.2 1 0 0 1 1 1 1 Legume-like lectin family Exonuc_X-T_C PF08411.10 EMD63484.1 - 0.0065 15.6 2.6 0.011 14.9 2.6 1.4 1 0 0 1 1 1 1 Exonuclease C-terminal Med14 PF08638.11 EMD63484.1 - 0.0081 15.6 0.1 0.015 14.7 0.1 1.4 1 0 0 1 1 1 1 Mediator complex subunit MED14 Adaptin_binding PF10199.9 EMD63484.1 - 0.016 15.8 0.3 0.016 15.8 0.3 1.7 2 0 0 2 2 2 0 Alpha and gamma adaptin binding protein p34 DUF2205 PF10224.9 EMD63484.1 - 0.02 14.9 1.0 0.02 14.9 1.0 2.0 2 0 0 2 2 2 0 Short coiled-coil protein Nas2_N PF18265.1 EMD63484.1 - 0.37 10.8 4.2 1.3 9.0 1.0 2.4 2 0 0 2 2 2 0 Nas2 N_terminal domain ANAPC_CDC26 PF10471.9 EMD63484.1 - 0.51 11.2 10.3 1 10.2 10.3 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex APC subunit CDC26 DUF948 PF06103.11 EMD63484.1 - 0.87 9.9 3.4 16 5.8 0.1 2.4 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) 7TMR-HDED PF07697.11 EMD63484.1 - 1.3 9.1 8.8 3 7.9 8.7 1.5 1 1 0 1 1 1 0 7TM-HD extracellular PBECR5 PF18814.1 EMD63484.1 - 2.4 8.0 7.6 3.8 7.4 7.6 1.2 1 0 0 1 1 1 0 phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease5 YabA PF06156.13 EMD63484.1 - 3.3 8.4 8.2 1 10.0 2.1 2.7 2 1 0 2 2 2 0 Initiation control protein YabA ZapB PF06005.12 EMD63484.1 - 4.5 7.8 11.8 0.29 11.6 1.1 2.4 2 1 0 2 2 2 0 Cell division protein ZapB Amidohydro_1 PF01979.20 EMD63485.1 - 1.9e-28 99.8 0.0 4.4e-28 98.6 0.0 1.6 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EMD63485.1 - 1.1e-16 61.4 0.0 2.8e-11 43.6 0.0 2.2 2 0 0 2 2 2 2 Amidohydrolase family 5-nucleotidase PF06189.12 EMD63485.1 - 0.089 11.7 0.0 0.14 11.1 0.0 1.2 1 0 0 1 1 1 0 5'-nucleotidase DUF1917 PF08939.10 EMD63486.1 - 3.3e-58 197.6 1.0 1.6e-43 149.5 0.0 2.1 1 1 1 2 2 2 2 Domain of unknown function (DUF1917) DNA_primase_S PF01896.19 EMD63487.1 - 1.3e-62 211.0 0.0 1.9e-62 210.5 0.0 1.2 1 0 0 1 1 1 1 DNA primase small subunit Glyco_hydro_20 PF00728.22 EMD63488.1 - 1.2e-87 294.6 0.0 1.5e-87 294.3 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.6 EMD63488.1 - 1.2e-24 87.5 0.0 2.1e-24 86.7 0.0 1.4 1 0 0 1 1 1 1 beta-acetyl hexosaminidase like Glyco_hydro_20b PF02838.15 EMD63488.1 - 0.0026 18.6 0.0 0.0064 17.3 0.0 1.7 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, domain 2 p450 PF00067.22 EMD63489.1 - 3e-63 214.2 0.0 3.7e-63 213.9 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 TM_helix PF05552.12 EMD63489.1 - 0.063 13.3 0.0 0.22 11.5 0.0 1.9 2 0 0 2 2 2 0 Conserved TM helix ELFV_dehydrog PF00208.21 EMD63490.1 - 8.5e-68 228.7 0.0 1.5e-67 227.9 0.0 1.4 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Bac_GDH PF05088.12 EMD63490.1 - 3e-18 64.9 0.0 8.2e-13 46.8 0.0 2.1 2 0 0 2 2 2 2 Bacterial NAD-glutamate dehydrogenase ELFV_dehydrog_N PF02812.18 EMD63490.1 - 0.035 14.0 0.0 0.092 12.6 0.0 1.6 1 0 0 1 1 1 0 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain Ppx-GppA PF02541.16 EMD63491.1 - 9.2e-44 150.0 0.0 1.8e-43 149.0 0.0 1.4 1 0 0 1 1 1 1 Ppx/GppA phosphatase family GDA1_CD39 PF01150.17 EMD63491.1 - 0.015 14.0 0.0 0.026 13.2 0.0 1.3 1 0 0 1 1 1 0 GDA1/CD39 (nucleoside phosphatase) family Rft-1 PF04506.13 EMD63492.1 - 8.5e-149 496.6 14.4 9.8e-149 496.4 14.4 1.0 1 0 0 1 1 1 1 Rft protein Polysacc_synt_3 PF13440.6 EMD63492.1 - 0.0023 17.2 19.4 0.0032 16.7 10.0 3.3 3 1 0 3 3 3 2 Polysaccharide biosynthesis protein Acetyltransf_3 PF13302.7 EMD63493.1 - 1e-28 100.7 0.0 1.3e-28 100.4 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EMD63493.1 - 0.043 14.0 0.0 0.12 12.7 0.0 1.7 2 0 0 2 2 2 0 Acetyltransferase (GNAT) family Periviscerokin PF08259.11 EMD63494.1 - 0.32 11.4 1.9 37 5.1 0.5 2.9 2 0 0 2 2 2 0 Periviscerokinin family TFIIIC_sub6 PF10419.9 EMD63495.1 - 2.9e-21 75.1 0.0 4.5e-21 74.5 0.0 1.3 1 0 0 1 1 1 1 TFIIIC subunit triple barrel domain Vps62 PF06101.11 EMD63496.1 - 3.2e-10 39.0 0.3 4.6e-10 38.4 0.3 1.2 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 62 DUF2291 PF10054.9 EMD63497.1 - 0.14 11.8 0.0 0.24 11.1 0.0 1.2 1 0 0 1 1 1 0 Predicted periplasmic lipoprotein (DUF2291) S-AdoMet_synt_C PF02773.16 EMD63498.1 - 9.4e-66 220.0 0.4 5e-65 217.7 0.0 2.0 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.16 EMD63498.1 - 1.5e-45 154.4 0.0 2.8e-45 153.4 0.0 1.5 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, central domain S-AdoMet_synt_N PF00438.20 EMD63498.1 - 1.5e-45 153.9 0.6 3.2e-45 152.8 0.1 1.8 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, N-terminal domain AdoMet_Synthase PF01941.19 EMD63498.1 - 0.0056 15.5 0.6 0.14 10.9 0.2 2.2 1 1 0 2 2 2 1 S-adenosylmethionine synthetase (AdoMet synthetase) ATP_bind_1 PF03029.17 EMD63499.1 - 1.8e-78 263.6 0.1 2.8e-78 263.0 0.1 1.3 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein CLP1_P PF16575.5 EMD63499.1 - 1.3e-05 25.1 0.0 3e-05 23.9 0.0 1.6 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_14 PF13173.6 EMD63499.1 - 0.0007 19.6 0.0 0.0026 17.8 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EMD63499.1 - 0.0037 17.5 0.0 0.0071 16.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EMD63499.1 - 0.0044 17.6 0.0 0.011 16.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 EMD63499.1 - 0.0049 16.6 0.0 0.012 15.3 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain RNA_helicase PF00910.22 EMD63499.1 - 0.0053 17.1 0.0 0.012 16.0 0.0 1.6 1 0 0 1 1 1 1 RNA helicase AAA_24 PF13479.6 EMD63499.1 - 0.0087 15.8 0.0 0.013 15.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EMD63499.1 - 0.012 16.0 0.0 0.096 13.1 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain RsgA_GTPase PF03193.16 EMD63499.1 - 0.018 14.9 0.0 0.28 11.1 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase ABC_tran PF00005.27 EMD63499.1 - 0.02 15.4 0.0 0.044 14.3 0.0 1.5 1 0 0 1 1 1 0 ABC transporter CbiA PF01656.23 EMD63499.1 - 0.021 14.9 0.0 0.027 14.5 0.0 1.4 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_33 PF13671.6 EMD63499.1 - 0.023 14.8 0.0 0.048 13.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 EMD63499.1 - 0.032 13.6 0.0 0.057 12.8 0.0 1.3 1 0 0 1 1 1 0 KaiC AAA PF00004.29 EMD63499.1 - 0.036 14.5 0.0 0.064 13.7 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 EMD63499.1 - 0.049 13.3 0.0 0.095 12.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain MeaB PF03308.16 EMD63499.1 - 0.059 12.3 0.0 1.7 7.6 0.0 2.0 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB KAP_NTPase PF07693.14 EMD63499.1 - 0.07 12.4 0.0 0.11 11.7 0.0 1.2 1 0 0 1 1 1 0 KAP family P-loop domain Sigma54_activat PF00158.26 EMD63499.1 - 0.071 12.8 0.0 0.11 12.2 0.0 1.2 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_7 PF12775.7 EMD63499.1 - 0.078 12.5 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region DUF463 PF04317.12 EMD63499.1 - 0.081 11.8 0.0 0.12 11.2 0.0 1.2 1 0 0 1 1 1 0 YcjX-like family, DUF463 NACHT PF05729.12 EMD63499.1 - 0.081 12.8 0.0 0.14 12.1 0.0 1.4 1 0 0 1 1 1 0 NACHT domain cobW PF02492.19 EMD63499.1 - 0.1 12.2 0.1 3.1 7.4 0.0 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain T2SSE PF00437.20 EMD63499.1 - 0.12 11.4 0.0 0.19 10.8 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein Cytidylate_kin PF02224.18 EMD63499.1 - 0.13 12.0 0.0 0.27 10.9 0.0 1.5 1 0 0 1 1 1 0 Cytidylate kinase GTP_EFTU PF00009.27 EMD63499.1 - 0.13 11.8 0.0 16 4.9 0.0 2.2 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EMD63499.1 - 0.13 12.3 0.0 0.51 10.4 0.0 2.0 1 1 0 1 1 1 0 50S ribosome-binding GTPase FtsK_SpoIIIE PF01580.18 EMD63499.1 - 0.14 11.5 0.0 0.32 10.3 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_19 PF13245.6 EMD63499.1 - 0.15 12.4 0.0 0.59 10.5 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 EMD63499.1 - 0.17 11.5 0.0 0.6 9.7 0.0 1.8 2 0 0 2 2 2 0 AAA domain PPV_E1_C PF00519.17 EMD63499.1 - 0.18 10.6 0.0 0.27 10.0 0.0 1.2 1 0 0 1 1 1 0 Papillomavirus helicase VTC PF09359.10 EMD63500.1 - 1.4e-97 326.4 0.4 1.4e-97 326.4 0.4 2.3 3 0 0 3 3 3 1 VTC domain DUF202 PF02656.15 EMD63500.1 - 8.4e-12 45.4 4.1 1.6e-11 44.4 4.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF202) SPX PF03105.19 EMD63500.1 - 5.8e-11 42.9 22.0 6.1e-05 23.1 0.9 4.1 2 1 1 4 4 4 3 SPX domain Peptidase_M32 PF02074.15 EMD63500.1 - 0.0051 15.7 1.1 0.0083 14.9 1.1 1.2 1 0 0 1 1 1 1 Carboxypeptidase Taq (M32) metallopeptidase Importin_rep_6 PF18829.1 EMD63500.1 - 1.5 9.0 9.4 5.4 7.2 3.5 3.0 2 0 0 2 2 2 0 Importin repeat 6 Patatin PF01734.22 EMD63502.1 - 9.5e-18 65.1 0.0 3.1e-10 40.6 0.0 2.3 2 0 0 2 2 2 2 Patatin-like phospholipase Glyco_trans_1_4 PF13692.6 EMD63505.1 - 2.6e-08 34.4 0.0 7.9e-07 29.6 0.0 2.3 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 EMD63505.1 - 1.9e-06 28.4 0.1 3.7e-06 27.5 0.1 1.4 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_transf_4 PF13439.6 EMD63505.1 - 1.2e-05 25.4 0.2 2.4e-05 24.4 0.2 1.4 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glycos_transf_1 PF00534.20 EMD63505.1 - 9.7e-05 22.0 0.0 0.0037 16.8 0.0 2.2 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 EMD63505.1 - 0.027 14.9 0.0 0.053 13.9 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferases group 1 Cation_efflux PF01545.21 EMD63506.1 - 5.6e-46 156.8 8.7 5.6e-46 156.8 8.7 2.6 3 0 0 3 3 3 1 Cation efflux family PGG PF13962.6 EMD63506.1 - 0.11 12.4 3.3 0.2 11.4 0.1 3.2 2 1 0 2 2 2 0 Domain of unknown function DNA_pol_E_B PF04042.16 EMD63507.1 - 1.3e-49 168.4 0.2 1.8e-49 167.9 0.2 1.2 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B SHNi-TPR PF10516.9 EMD63508.1 - 3.6e-20 71.1 1.1 8.4e-16 57.1 0.3 2.5 2 0 0 2 2 2 2 SHNi-TPR TPR_12 PF13424.6 EMD63508.1 - 0.00046 20.4 5.1 0.058 13.7 0.2 2.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.6 EMD63508.1 - 0.0027 17.5 0.7 1.3 9.0 0.1 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 EMD63508.1 - 6.3 7.2 10.0 7.2 7.0 0.0 4.3 5 0 0 5 5 5 0 Tetratricopeptide repeat adh_short_C2 PF13561.6 EMD63509.1 - 3.2e-43 148.0 0.0 3.7e-42 144.5 0.0 1.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EMD63509.1 - 3.6e-39 134.3 0.1 9.1e-38 129.7 0.1 2.0 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EMD63509.1 - 5e-08 33.1 0.0 7.2e-08 32.5 0.0 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EMD63509.1 - 0.0071 15.8 0.0 0.01 15.3 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EMD63509.1 - 0.11 11.7 0.0 0.15 11.2 0.0 1.1 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein MaoC_dehydratas PF01575.19 EMD63510.1 - 1.6e-07 31.0 0.0 2.5e-07 30.3 0.0 1.3 1 0 0 1 1 1 1 MaoC like domain Zn_clus PF00172.18 EMD63511.1 - 1.6e-08 34.6 11.0 2.6e-08 33.8 11.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EMD63511.1 - 4.6e-06 25.7 0.2 7e-06 25.1 0.2 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain ADH_N_2 PF16884.5 EMD63512.1 - 5.9e-25 87.3 0.0 1.3e-24 86.1 0.0 1.6 2 0 0 2 2 2 1 N-terminal domain of oxidoreductase ADH_zinc_N PF00107.26 EMD63512.1 - 1.3e-19 70.5 1.5 1.3e-19 70.5 1.5 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EMD63512.1 - 5.6e-10 40.4 0.0 1e-09 39.6 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase SRP_TPR_like PF17004.5 EMD63513.1 - 4e-21 75.2 5.7 9e-21 74.1 3.6 2.4 2 0 0 2 2 2 1 Putative TPR-like repeat SRP72 PF08492.12 EMD63513.1 - 1.1e-14 54.6 5.1 1.1e-14 54.6 5.1 2.6 2 0 0 2 2 2 1 SRP72 RNA-binding domain TPR_19 PF14559.6 EMD63513.1 - 5.6e-09 36.4 27.2 0.002 18.6 3.9 7.6 4 3 3 8 8 8 3 Tetratricopeptide repeat TPR_14 PF13428.6 EMD63513.1 - 4.9e-07 30.0 16.9 1.7 9.7 0.1 7.4 5 1 2 7 7 7 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EMD63513.1 - 3.6e-05 23.9 16.7 0.47 10.7 0.3 5.4 5 1 1 6 6 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.17 EMD63513.1 - 0.00063 19.7 24.2 0.13 12.4 0.2 6.8 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_4 PF07721.14 EMD63513.1 - 0.0027 18.2 10.4 2.1 9.2 0.6 5.9 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_12 PF13424.6 EMD63513.1 - 0.0058 16.9 9.9 2.1 8.7 1.8 5.7 5 1 0 5 5 5 1 Tetratricopeptide repeat TPR_20 PF14561.6 EMD63513.1 - 0.011 16.0 8.8 1 9.7 1.8 3.7 2 1 1 3 3 3 0 Tetratricopeptide repeat DUF4012 PF13196.6 EMD63513.1 - 0.013 15.9 0.2 0.77 10.2 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4012) TPR_16 PF13432.6 EMD63513.1 - 0.022 15.4 21.6 0.44 11.2 0.6 5.6 5 1 1 6 6 6 0 Tetratricopeptide repeat AcylCoA_dehyd_C PF12186.8 EMD63513.1 - 0.023 14.8 0.1 0.13 12.4 0.1 2.3 2 0 0 2 2 1 0 Acyl-CoA dehydrogenase C terminal DUF4810 PF16068.5 EMD63513.1 - 0.051 14.1 0.7 0.45 11.1 0.0 2.8 3 0 0 3 3 2 0 Domain of unknown function (DUF4810) SPOB_a PF14689.6 EMD63513.1 - 0.085 12.6 0.1 9.7 6.0 0.0 3.2 3 0 0 3 3 3 0 Sensor_kinase_SpoOB-type, alpha-helical domain DUF4749 PF15936.5 EMD63513.1 - 0.09 13.9 0.4 0.61 11.2 0.4 2.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4749) TPR_9 PF13371.6 EMD63513.1 - 0.23 11.6 0.0 0.23 11.6 0.0 4.4 5 1 0 5 5 3 0 Tetratricopeptide repeat TPR_10 PF13374.6 EMD63513.1 - 1.6 8.7 11.7 18 5.4 0.0 5.4 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_8 PF13181.6 EMD63513.1 - 3.4 8.1 15.7 22 5.6 0.0 5.9 6 1 1 7 7 6 0 Tetratricopeptide repeat TPR_17 PF13431.6 EMD63513.1 - 4.1 8.0 6.9 18 6.0 0.2 3.9 4 0 0 4 4 3 0 Tetratricopeptide repeat TFIIE_alpha PF02002.17 EMD63514.1 - 1.3e-08 34.7 0.0 2.2e-08 33.9 0.0 1.4 1 0 0 1 1 1 1 TFIIE alpha subunit DUF4611 PF15387.6 EMD63514.1 - 0.0095 16.1 5.6 0.0095 16.1 5.6 2.4 3 0 0 3 3 3 1 Domain of unknown function (DUF4611) Tub PF01167.18 EMD63514.1 - 0.02 14.6 0.0 0.067 12.9 0.0 1.7 1 1 0 1 1 1 0 Tub family Zn-ribbon_8 PF09723.10 EMD63514.1 - 0.14 12.3 0.2 3.3 7.9 0.0 2.4 2 0 0 2 2 2 0 Zinc ribbon domain Voldacs PF03517.13 EMD63514.1 - 0.33 11.1 6.4 0.84 9.8 6.4 1.7 1 0 0 1 1 1 0 Regulator of volume decrease after cellular swelling Mif2_N PF15624.6 EMD63514.1 - 1.8 9.3 6.0 0.91 10.2 1.5 2.3 2 0 0 2 2 2 0 Kinetochore CENP-C fungal homologue, Mif2, N-terminal NINJA_B PF16136.5 EMD63514.1 - 2.5 8.5 6.5 1.1 9.7 0.4 2.3 1 1 1 2 2 2 0 Putative nuclear localisation signal MPP6 PF10175.9 EMD63514.1 - 5.9 7.4 10.0 13 6.3 10.0 1.5 1 0 0 1 1 1 0 M-phase phosphoprotein 6 DNA_pol_phi PF04931.13 EMD63514.1 - 6.3 4.8 10.2 10 4.0 10.2 1.3 1 0 0 1 1 1 0 DNA polymerase phi SURF2 PF05477.11 EMD63514.1 - 8.3 6.0 7.9 14 5.3 7.9 1.2 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) NOA36 PF06524.12 EMD63514.1 - 8.7 5.6 11.3 3.4 6.9 7.3 2.0 2 0 0 2 2 2 0 NOA36 protein PseudoU_synth_1 PF01416.20 EMD63515.1 - 5e-09 36.6 0.0 2.3e-07 31.2 0.0 2.8 3 0 0 3 3 3 1 tRNA pseudouridine synthase Taq-exonuc PF09281.10 EMD63515.1 - 0.0093 16.0 0.1 0.0093 16.0 0.1 2.1 2 0 0 2 2 2 1 Taq polymerase, exonuclease Ku PF02735.16 EMD63516.1 - 5.9e-50 169.8 0.0 1.5e-49 168.5 0.0 1.6 2 0 0 2 2 2 1 Ku70/Ku80 beta-barrel domain Ku_N PF03731.15 EMD63516.1 - 4.4e-28 98.5 0.0 7.4e-28 97.8 0.0 1.4 1 0 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain Ku_C PF03730.14 EMD63516.1 - 4.5e-25 88.2 2.0 4.5e-25 88.2 2.0 2.6 3 1 0 3 3 3 1 Ku70/Ku80 C-terminal arm SAP PF02037.27 EMD63516.1 - 4.5e-09 35.9 0.1 9.6e-09 34.8 0.1 1.6 1 0 0 1 1 1 1 SAP domain Flu_M1_C PF08289.11 EMD63516.1 - 0.16 12.2 0.4 0.53 10.5 0.3 2.0 1 1 0 1 1 1 0 Influenza Matrix protein (M1) C-terminal domain Ferrochelatase PF00762.19 EMD63517.1 - 5.2e-98 328.0 0.0 6.2e-98 327.8 0.0 1.1 1 0 0 1 1 1 1 Ferrochelatase HET PF06985.11 EMD63518.1 - 3.9e-26 92.1 4.2 6.1e-26 91.5 4.2 1.3 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) E1_dh PF00676.20 EMD63519.1 - 3.6e-116 387.3 0.1 4.2e-116 387.1 0.1 1.0 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.6 EMD63519.1 - 0.0011 18.2 0.1 0.0018 17.6 0.1 1.3 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase TPP_enzyme_C PF02775.21 EMD63519.1 - 0.039 13.8 1.6 0.08 12.7 1.6 1.5 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain BMC PF00936.19 EMD63519.1 - 0.051 13.6 0.0 0.24 11.4 0.0 2.0 2 0 0 2 2 2 0 BMC domain EST1_DNA_bind PF10373.9 EMD63520.1 - 1e-09 38.3 0.0 3.7e-09 36.5 0.0 1.9 2 0 0 2 2 2 1 Est1 DNA/RNA binding domain MFS_1 PF07690.16 EMD63521.1 - 2.4e-22 79.4 28.3 4.7e-22 78.4 15.2 2.6 2 1 1 3 3 3 2 Major Facilitator Superfamily HATPase_c PF02518.26 EMD63521.1 - 2e-16 60.5 0.0 4.1e-16 59.5 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EMD63521.1 - 2e-15 56.9 0.0 4.1e-15 55.9 0.0 1.5 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 EMD63521.1 - 5.4e-13 48.8 0.1 1.3e-12 47.5 0.1 1.7 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain Sugar_tr PF00083.24 EMD63521.1 - 1.4e-08 34.0 0.6 2.4e-08 33.3 0.6 1.3 1 0 0 1 1 1 1 Sugar (and other) transporter DUF5326 PF17260.2 EMD63521.1 - 0.033 14.3 0.8 0.11 12.6 0.8 1.8 1 0 0 1 1 1 0 Family of unknown function (DUF5326) TRI12 PF06609.13 EMD63521.1 - 0.076 11.4 0.9 0.12 10.8 0.0 1.7 2 0 0 2 2 2 0 Fungal trichothecene efflux pump (TRI12) Glycos_transf_2 PF00535.26 EMD63522.1 - 4.4e-24 85.2 0.0 1.2e-11 44.8 0.0 2.2 2 0 0 2 2 2 2 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 EMD63522.1 - 4.5e-06 26.7 0.1 0.022 14.7 0.1 2.8 1 1 1 2 2 2 2 Glycosyltransferase like family 2 DUF1145 PF06611.12 EMD63522.1 - 0.71 9.9 4.2 0.29 11.1 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1145) Kelch_3 PF13415.6 EMD63523.1 - 1.6e-21 76.1 11.3 2.9e-06 27.4 0.0 6.7 6 1 1 7 7 7 3 Galactose oxidase, central domain Kelch_4 PF13418.6 EMD63523.1 - 3.2e-17 62.3 9.5 4.7e-07 29.7 0.1 5.3 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_5 PF13854.6 EMD63523.1 - 9.8e-17 60.5 6.4 0.004 17.1 0.0 6.1 6 0 0 6 6 6 4 Kelch motif Kelch_1 PF01344.25 EMD63523.1 - 2e-14 52.9 0.1 0.0029 17.2 0.1 3.7 3 0 0 3 3 3 3 Kelch motif Kelch_6 PF13964.6 EMD63523.1 - 1.6e-13 50.4 3.0 0.00022 21.4 0.0 4.8 5 0 0 5 5 5 3 Kelch motif Kelch_2 PF07646.15 EMD63523.1 - 1.7e-09 37.3 2.3 0.094 12.7 0.0 4.7 5 0 0 5 5 5 3 Kelch motif CoA_transf_3 PF02515.17 EMD63524.1 - 1.7e-44 152.5 0.3 7.3e-44 150.4 0.1 2.0 2 1 0 2 2 2 1 CoA-transferase family III p450 PF00067.22 EMD63525.1 - 1.4e-57 195.5 0.0 1.8e-57 195.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 YcaO_C PF18381.1 EMD63525.1 - 0.05 13.5 0.0 1.6 8.6 0.1 2.3 1 1 1 2 2 2 0 YcaO cyclodehydratase C-terminal domain EthD PF07110.11 EMD63525.1 - 0.056 14.6 0.0 25 6.1 0.0 2.6 2 0 0 2 2 2 0 EthD domain Pro-kuma_activ PF09286.11 EMD63526.1 - 1.6e-21 77.1 0.1 2.7e-21 76.4 0.1 1.4 1 0 0 1 1 1 1 Pro-kumamolisin, activation domain Say1_Mug180 PF10340.9 EMD63527.1 - 6.4e-22 77.9 0.0 7.5e-22 77.7 0.0 1.1 1 0 0 1 1 1 1 Steryl acetyl hydrolase Abhydrolase_3 PF07859.13 EMD63527.1 - 1.6e-21 77.2 0.0 2.1e-21 76.7 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Baculo_VP91_N PF08475.10 EMD63528.1 - 2.1 8.0 4.4 3.8 7.2 4.4 1.3 1 0 0 1 1 1 0 Viral capsid protein 91 N-terminal P5CR_dimer PF14748.6 EMD63529.1 - 6.2e-35 119.6 3.1 1.3e-34 118.5 3.1 1.6 1 0 0 1 1 1 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.17 EMD63529.1 - 3.2e-08 34.0 1.1 2.4e-07 31.3 0.2 2.6 2 1 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent CTK3 PF12243.8 EMD63530.1 - 7.2e-48 161.7 0.7 1.1e-47 161.1 0.7 1.2 1 0 0 1 1 1 1 CTD kinase subunit gamma CTK3 CTK3_C PF12350.8 EMD63530.1 - 3.7e-22 78.3 10.8 7.6e-22 77.3 10.8 1.5 1 0 0 1 1 1 1 CTD kinase subunit gamma CTK3 C-terminus Ribosomal_L12 PF00542.19 EMD63531.1 - 1.5e-21 76.5 7.6 1e-20 73.8 6.2 2.1 2 0 0 2 2 2 1 Ribosomal protein L7/L12 C-terminal domain Ribosomal_L12_N PF16320.5 EMD63531.1 - 5.1e-13 48.5 8.7 1.7e-12 46.8 6.4 2.9 2 1 0 2 2 2 1 Ribosomal protein L7/L12 dimerisation domain DAHP_snth_FXD PF18152.1 EMD63531.1 - 0.065 13.1 0.1 0.23 11.3 0.1 1.9 1 0 0 1 1 1 0 DAHP synthase ferredoxin-like domain AAA_5 PF07728.14 EMD63532.1 - 4e-130 428.5 0.1 2.3e-22 79.5 0.0 9.8 9 0 0 9 9 9 9 AAA domain (dynein-related subfamily) AAA_lid_7 PF17867.1 EMD63532.1 - 3.3e-52 175.1 11.8 1.7e-24 86.1 0.3 5.8 5 0 0 5 5 4 3 Midasin AAA lid domain AAA_7 PF12775.7 EMD63532.1 - 9.5e-30 103.5 1.4 2.1e-05 24.1 0.0 7.3 7 0 0 7 7 7 6 P-loop containing dynein motor region AAA PF00004.29 EMD63532.1 - 1.2e-29 103.4 0.0 0.00013 22.4 0.0 7.2 6 0 0 6 6 6 5 ATPase family associated with various cellular activities (AAA) AAA_3 PF07726.11 EMD63532.1 - 1.5e-28 99.3 0.0 8.1e-10 38.7 0.0 8.2 8 0 0 8 8 8 4 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EMD63532.1 - 3.6e-28 99.1 12.7 0.0013 19.2 0.2 9.4 8 2 0 8 8 6 6 AAA ATPase domain AAA_lid_5 PF17865.1 EMD63532.1 - 8.4e-27 93.3 0.0 5.4e-26 90.7 0.0 2.5 2 0 0 2 2 1 1 Midasin AAA lid domain Dynein_heavy PF03028.15 EMD63532.1 - 5.5e-24 84.5 0.0 0.00026 21.1 0.0 8.4 8 0 0 8 8 7 4 Dynein heavy chain region D6 P-loop domain AAA_22 PF13401.6 EMD63532.1 - 9.8e-24 84.2 5.6 0.00027 21.2 0.0 8.8 8 0 0 8 8 7 4 AAA domain AAA_18 PF13238.6 EMD63532.1 - 6e-23 81.8 0.1 0.00053 20.5 0.0 7.6 6 0 0 6 6 6 5 AAA domain Sigma54_activat PF00158.26 EMD63532.1 - 2.2e-22 79.5 0.0 0.0012 18.6 0.0 6.7 6 0 0 6 6 6 5 Sigma-54 interaction domain Sigma54_activ_2 PF14532.6 EMD63532.1 - 2.6e-20 73.0 0.1 0.00056 20.0 0.0 6.7 6 0 0 6 6 6 4 Sigma-54 interaction domain AAA_6 PF12774.7 EMD63532.1 - 1.5e-19 70.1 0.0 0.0037 16.3 0.0 9.0 9 1 0 9 9 9 3 Hydrolytic ATP binding site of dynein motor region AAA_14 PF13173.6 EMD63532.1 - 4.4e-17 62.3 0.0 0.0025 17.9 0.0 7.8 7 0 0 7 7 7 2 AAA domain T2SSE PF00437.20 EMD63532.1 - 5.4e-17 61.7 4.0 0.00088 18.4 0.0 6.7 6 0 0 6 6 6 5 Type II/IV secretion system protein AAA_30 PF13604.6 EMD63532.1 - 1.9e-16 60.4 0.5 0.082 12.6 0.0 9.1 9 1 0 9 9 8 2 AAA domain AAA_33 PF13671.6 EMD63532.1 - 2e-16 60.4 1.6 0.17 12.0 0.0 8.0 8 0 0 8 8 6 3 AAA domain TsaE PF02367.17 EMD63532.1 - 4.9e-16 58.9 4.0 0.093 12.7 0.0 6.8 7 0 0 7 7 6 4 Threonylcarbamoyl adenosine biosynthesis protein TsaE RNA_helicase PF00910.22 EMD63532.1 - 2e-15 57.1 0.5 0.26 11.7 0.0 6.8 6 0 0 6 6 6 4 RNA helicase RuvB_N PF05496.12 EMD63532.1 - 8.8e-14 51.5 0.3 0.039 13.7 0.0 6.6 7 0 0 7 7 5 2 Holliday junction DNA helicase RuvB P-loop domain ABC_tran PF00005.27 EMD63532.1 - 6.9e-13 49.3 12.8 0.03 14.9 0.0 9.0 9 0 0 9 9 7 3 ABC transporter Zeta_toxin PF06414.12 EMD63532.1 - 9.1e-13 47.9 0.1 1.9 7.7 0.0 7.1 6 0 0 6 6 6 2 Zeta toxin AAA_19 PF13245.6 EMD63532.1 - 1.1e-12 48.6 4.0 0.58 10.5 0.0 7.6 7 0 0 7 7 6 3 AAA domain Mg_chelatase PF01078.21 EMD63532.1 - 2.5e-12 46.6 0.0 0.66 9.3 0.0 9.1 9 0 0 9 9 9 1 Magnesium chelatase, subunit ChlI NACHT PF05729.12 EMD63532.1 - 3.5e-12 46.6 4.3 0.19 11.6 0.1 6.7 7 0 0 7 7 6 2 NACHT domain AAA_28 PF13521.6 EMD63532.1 - 6.2e-12 46.1 5.5 0.11 12.7 0.0 7.2 8 0 0 8 8 6 1 AAA domain Rad17 PF03215.15 EMD63532.1 - 7.6e-12 45.5 0.1 0.68 9.8 0.0 5.8 5 0 0 5 5 5 2 Rad17 P-loop domain AAA_25 PF13481.6 EMD63532.1 - 1.1e-10 41.5 4.1 0.44 10.1 0.0 6.3 6 0 0 6 6 6 2 AAA domain ResIII PF04851.15 EMD63532.1 - 1e-09 38.7 0.1 0.66 10.0 0.0 6.6 6 0 0 6 6 6 1 Type III restriction enzyme, res subunit IstB_IS21 PF01695.17 EMD63532.1 - 2.2e-09 37.3 0.5 2.1 8.1 0.0 6.5 6 0 0 6 6 6 1 IstB-like ATP binding protein AAA_29 PF13555.6 EMD63532.1 - 2.5e-09 36.7 1.1 2.1 8.2 0.0 6.8 7 0 0 7 7 6 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EMD63532.1 - 2.9e-09 37.1 4.0 1.6 8.6 0.0 6.4 6 0 0 6 6 6 2 RsgA GTPase ATPase_2 PF01637.18 EMD63532.1 - 3.8e-09 36.8 0.1 1.1 9.1 0.0 6.0 6 0 0 6 6 5 1 ATPase domain predominantly from Archaea SRP54 PF00448.22 EMD63532.1 - 4.7e-09 36.2 2.4 1.6 8.3 0.0 5.9 6 0 0 6 6 5 1 SRP54-type protein, GTPase domain AAA_24 PF13479.6 EMD63532.1 - 1.5e-07 31.3 0.0 4.4 7.0 0.0 6.6 6 0 0 6 6 6 0 AAA domain PduV-EutP PF10662.9 EMD63532.1 - 1.7e-07 31.1 1.6 0.032 14.0 0.0 5.7 6 0 0 6 6 6 1 Ethanolamine utilisation - propanediol utilisation TniB PF05621.11 EMD63532.1 - 3.4e-07 29.9 0.2 0.81 9.1 0.0 5.8 6 0 0 6 6 6 1 Bacterial TniB protein MMR_HSR1 PF01926.23 EMD63532.1 - 1.4e-06 28.4 0.9 9.8 6.3 0.0 5.9 5 0 0 5 5 5 0 50S ribosome-binding GTPase ATPase PF06745.13 EMD63532.1 - 3.2e-06 26.6 7.8 0.018 14.4 0.0 6.0 7 0 0 7 7 5 1 KaiC SRPRB PF09439.10 EMD63532.1 - 5.7e-06 25.9 0.8 1.4 8.3 0.0 5.8 6 0 0 6 6 6 1 Signal recognition particle receptor beta subunit Viral_helicase1 PF01443.18 EMD63532.1 - 5.7e-06 26.2 0.1 19 4.9 0.0 6.2 6 0 0 6 6 5 0 Viral (Superfamily 1) RNA helicase NTPase_1 PF03266.15 EMD63532.1 - 6.6e-06 26.1 5.9 1.8 8.4 0.1 5.7 5 0 0 5 5 5 1 NTPase KAP_NTPase PF07693.14 EMD63532.1 - 7.3e-06 25.4 0.0 3.6 6.7 0.0 5.5 5 0 0 5 5 5 0 KAP family P-loop domain TIP49 PF06068.13 EMD63532.1 - 1.8e-05 24.1 0.4 0.4 9.8 0.0 5.1 6 0 0 6 6 6 1 TIP49 P-loop domain DUF815 PF05673.13 EMD63532.1 - 1.9e-05 24.0 0.2 9 5.4 0.0 5.2 5 0 0 5 5 5 0 Protein of unknown function (DUF815) Roc PF08477.13 EMD63532.1 - 2.6e-05 24.4 2.8 34 4.7 0.0 6.1 6 0 0 6 6 5 0 Ras of Complex, Roc, domain of DAPkinase PhoH PF02562.16 EMD63532.1 - 2.6e-05 23.8 0.4 9 5.7 0.0 5.5 6 0 0 6 6 5 0 PhoH-like protein cobW PF02492.19 EMD63532.1 - 9.9e-05 22.0 9.4 2 7.9 0.0 6.4 7 0 0 7 7 6 1 CobW/HypB/UreG, nucleotide-binding domain dNK PF01712.19 EMD63532.1 - 0.00025 20.9 11.2 1.6 8.6 0.1 6.4 7 0 0 7 7 6 1 Deoxynucleoside kinase DUF853 PF05872.12 EMD63532.1 - 0.00057 18.6 0.1 0.58 8.7 0.0 3.2 3 0 0 3 3 2 1 Bacterial protein of unknown function (DUF853) FtsK_SpoIIIE PF01580.18 EMD63532.1 - 0.0011 18.4 0.3 6.9 5.9 0.0 4.7 5 0 0 5 5 5 0 FtsK/SpoIIIE family VWA PF00092.28 EMD63532.1 - 0.0013 19.0 0.1 0.0045 17.3 0.1 2.0 1 0 0 1 1 1 1 von Willebrand factor type A domain Thymidylate_kin PF02223.17 EMD63532.1 - 0.0018 18.0 3.1 2.2 7.9 0.0 5.5 7 0 0 7 7 5 1 Thymidylate kinase CbiA PF01656.23 EMD63532.1 - 0.006 16.6 1.2 9.5 6.3 0.2 5.1 6 0 0 6 6 4 0 CobQ/CobB/MinD/ParA nucleotide binding domain KTI12 PF08433.10 EMD63532.1 - 0.008 15.7 3.6 21 4.4 0.0 5.7 7 0 0 7 7 5 0 Chromatin associated protein KTI12 VWA_2 PF13519.6 EMD63532.1 - 0.0082 16.8 0.1 0.04 14.6 0.1 2.4 1 0 0 1 1 1 1 von Willebrand factor type A domain vWA-TerF-like PF10138.9 EMD63532.1 - 0.0093 16.1 0.2 0.028 14.5 0.2 1.8 1 0 0 1 1 1 1 vWA found in TerF C terminus ATP-synt_ab PF00006.25 EMD63532.1 - 0.01 15.5 0.0 17 4.9 0.0 4.0 5 0 0 5 5 3 0 ATP synthase alpha/beta family, nucleotide-binding domain ATP_bind_1 PF03029.17 EMD63532.1 - 0.011 15.5 12.4 4.2 7.1 0.0 6.8 8 0 0 8 8 8 0 Conserved hypothetical ATP binding protein Cytidylate_kin PF02224.18 EMD63532.1 - 0.014 15.1 0.1 39 3.9 0.0 4.5 4 0 0 4 4 4 0 Cytidylate kinase Bac_DnaA PF00308.18 EMD63532.1 - 0.016 15.0 0.3 71 3.1 0.0 4.8 6 0 0 6 6 4 0 Bacterial dnaA protein CPT PF07931.12 EMD63532.1 - 0.029 14.2 0.1 39 4.0 0.0 4.9 4 0 0 4 4 3 0 Chloramphenicol phosphotransferase-like protein PRK PF00485.18 EMD63532.1 - 0.056 13.2 0.1 9.8 5.9 0.0 4.2 5 0 0 5 5 4 0 Phosphoribulokinase / Uridine kinase family APS_kinase PF01583.20 EMD63532.1 - 0.068 13.1 0.5 5.9 6.8 0.0 4.1 5 0 0 5 5 3 0 Adenylylsulphate kinase FeoB_N PF02421.18 EMD63532.1 - 0.11 12.0 2.7 14 5.2 0.1 3.9 4 0 0 4 4 3 0 Ferrous iron transport protein B tRNA_lig_kinase PF08303.11 EMD63532.1 - 0.23 11.6 2.5 0.62 10.1 0.1 2.9 2 0 0 2 2 2 0 tRNA ligase kinase domain DUF87 PF01935.17 EMD63532.1 - 0.28 11.2 2.5 24 4.9 0.0 4.6 4 0 0 4 4 2 0 Helicase HerA, central domain MobB PF03205.14 EMD63532.1 - 0.77 9.7 8.1 92 2.9 0.1 6.2 7 0 0 7 7 6 0 Molybdopterin guanine dinucleotide synthesis protein B PI-TkoII_IV PF18714.1 EMD63533.1 - 0.042 13.3 0.0 0.045 13.2 0.0 1.2 1 0 0 1 1 1 0 DNA polymerase II intein Domain IV Trans_coact PF16805.5 EMD63533.1 - 0.13 12.3 0.1 0.2 11.8 0.1 1.3 1 0 0 1 1 1 0 Phage late-transcription coactivator ADH_zinc_N PF00107.26 EMD63534.1 - 3.3e-26 91.8 0.2 6.5e-26 90.8 0.0 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EMD63534.1 - 4e-22 78.2 1.3 4e-22 78.2 1.3 1.7 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_N_2 PF16884.5 EMD63534.1 - 0.063 13.2 0.0 1.1 9.2 0.0 2.3 2 0 0 2 2 2 0 N-terminal domain of oxidoreductase Abhydrolase_1 PF00561.20 EMD63535.1 - 2.8e-51 174.6 0.0 2e-50 171.9 0.0 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EMD63535.1 - 0.00066 20.3 2.7 0.00086 20.0 1.5 1.6 1 1 0 2 2 2 1 Alpha/beta hydrolase family Say1_Mug180 PF10340.9 EMD63535.1 - 0.0048 15.8 0.0 0.0073 15.2 0.0 1.2 1 0 0 1 1 1 1 Steryl acetyl hydrolase Hydrolase_4 PF12146.8 EMD63535.1 - 0.072 12.3 0.0 0.4 9.9 0.0 2.0 2 0 0 2 2 2 0 Serine aminopeptidase, S33 ketoacyl-synt PF00109.26 EMD63536.1 - 1.3e-61 208.4 0.6 1.3e-60 205.2 0.0 2.0 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 EMD63536.1 - 1.4e-35 121.9 0.7 7.3e-35 119.5 0.3 2.0 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.23 EMD63536.1 - 7.9e-06 25.4 0.4 0.00052 19.5 0.1 2.2 2 0 0 2 2 2 2 Thiolase, N-terminal domain Thiolase_C PF02803.18 EMD63536.1 - 0.00018 21.1 1.1 0.034 13.8 0.3 3.5 3 1 0 3 3 3 1 Thiolase, C-terminal domain NicO PF03824.16 EMD63537.1 - 1.3e-67 228.1 9.2 1.3e-67 228.1 9.2 1.4 2 0 0 2 2 2 1 High-affinity nickel-transport protein GAPT PF11770.8 EMD63537.1 - 0.021 14.7 0.2 0.047 13.6 0.2 1.5 1 0 0 1 1 1 0 GRB2-binding adapter (GAPT) DHHC PF01529.20 EMD63537.1 - 2.3 8.3 8.7 60 3.7 0.2 3.5 2 1 1 3 3 3 0 DHHC palmitoyltransferase CAF1 PF04857.20 EMD63538.1 - 1e-72 245.0 0.1 3.3e-71 240.1 0.0 2.0 2 0 0 2 2 2 2 CAF1 family ribonuclease Androgen_recep PF02166.16 EMD63539.1 - 0.19 10.6 1.5 0.27 10.1 1.5 1.2 1 0 0 1 1 1 0 Androgen receptor Pex26 PF07163.12 EMD63539.1 - 0.22 10.8 3.5 0.34 10.2 2.6 1.7 1 1 0 1 1 1 0 Pex26 protein CDC45 PF02724.14 EMD63539.1 - 0.36 9.1 9.3 0.47 8.7 9.3 1.1 1 0 0 1 1 1 0 CDC45-like protein Pro-rich PF15240.6 EMD63539.1 - 0.43 10.8 14.0 0.24 11.6 11.9 1.6 2 0 0 2 2 2 0 Proline-rich Rrn6 PF10214.9 EMD63539.1 - 0.58 8.6 15.3 0.041 12.4 10.7 1.4 2 0 0 2 2 2 0 RNA polymerase I-specific transcription-initiation factor Presenilin PF01080.17 EMD63539.1 - 0.66 8.7 5.9 0.96 8.1 5.9 1.2 1 0 0 1 1 1 0 Presenilin SpoVR PF04293.13 EMD63539.1 - 4.3 5.9 6.9 6.7 5.3 6.9 1.2 1 0 0 1 1 1 0 SpoVR like protein PTPLA PF04387.14 EMD63540.1 - 8.1e-49 165.5 9.7 1.3e-48 164.8 9.7 1.3 1 0 0 1 1 1 1 Protein tyrosine phosphatase-like protein, PTPLA Abhydrolase_6 PF12697.7 EMD63541.1 - 2.7e-10 41.2 4.7 3.1e-10 41.0 4.7 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EMD63541.1 - 4.6e-10 39.6 0.0 5.6e-08 32.7 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EMD63541.1 - 2.7e-05 23.6 0.1 7.3e-05 22.1 0.1 1.7 1 1 0 1 1 1 1 Serine aminopeptidase, S33 FSH1 PF03959.13 EMD63541.1 - 0.0092 15.7 0.2 0.18 11.4 0.2 2.3 1 1 0 1 1 1 1 Serine hydrolase (FSH1) TPP_enzyme_C PF02775.21 EMD63541.1 - 0.11 12.3 0.0 0.2 11.5 0.0 1.5 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain COesterase PF00135.28 EMD63542.1 - 5e-85 286.3 0.0 6.7e-85 285.9 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EMD63542.1 - 1.2e-07 31.8 0.0 6.2e-07 29.5 0.0 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EMD63542.1 - 0.0069 15.9 0.1 0.011 15.2 0.1 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family EVE PF01878.18 EMD63543.1 - 2.3e-47 160.6 0.0 4e-47 159.9 0.0 1.4 1 0 0 1 1 1 1 EVE domain Suf PF05843.14 EMD63543.1 - 0.39 10.7 6.1 0.53 10.2 6.1 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Presenilin PF01080.17 EMD63543.1 - 2.5 6.8 5.4 3.4 6.4 5.4 1.2 1 0 0 1 1 1 0 Presenilin Ndc1_Nup PF09531.10 EMD63543.1 - 6.4 5.3 9.1 7.3 5.2 9.1 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Abhydrolase_1 PF00561.20 EMD63544.1 - 4.3e-21 75.7 0.0 9.7e-21 74.6 0.0 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EMD63544.1 - 1.1e-12 49.0 0.1 1.8e-12 48.4 0.1 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EMD63544.1 - 4e-09 36.1 0.0 1.4e-08 34.3 0.0 1.7 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Ndr PF03096.14 EMD63544.1 - 0.037 12.7 0.0 0.056 12.1 0.0 1.2 1 0 0 1 1 1 0 Ndr family zf-C3HC4 PF00097.25 EMD63545.1 - 1.7e-07 31.0 6.6 1.7e-07 31.0 6.6 4.6 5 1 0 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.6 EMD63545.1 - 8.8e-07 28.7 0.4 8.8e-07 28.7 0.4 3.0 3 0 0 3 3 3 1 zf-RING of BARD1-type protein zf-RING_2 PF13639.6 EMD63545.1 - 1.8e-06 28.1 6.9 1.8e-06 28.1 6.9 4.4 4 1 0 4 4 4 1 Ring finger domain zf-RING_UBOX PF13445.6 EMD63545.1 - 2.6e-06 27.3 5.6 2.6e-06 27.3 5.6 3.3 3 0 0 3 3 3 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EMD63545.1 - 8.5e-06 25.5 8.0 8.5e-06 25.5 8.0 4.2 5 3 1 6 6 6 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EMD63545.1 - 5.2e-05 23.0 3.2 5.2e-05 23.0 3.2 5.0 4 3 1 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EMD63545.1 - 0.00017 21.7 8.4 0.00017 21.7 8.4 3.7 6 1 0 6 6 6 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 EMD63545.1 - 0.0004 20.3 5.6 0.0004 20.3 5.6 5.4 5 1 0 5 5 5 1 zinc-RING finger domain CpXC PF14353.6 EMD63545.1 - 0.29 11.2 0.1 0.29 11.2 0.1 2.8 2 0 0 2 2 2 0 CpXC protein zf-4CXXC_R1 PF10497.9 EMD63545.1 - 6.2 7.1 31.4 0.061 13.5 0.8 4.3 4 0 0 4 4 4 0 Zinc-finger domain of monoamine-oxidase A repressor R1 Collagen PF01391.18 EMD63546.1 - 0.81 9.5 101.5 1.1e+04 -3.8 0.7 4.9 2 1 0 2 2 2 0 Collagen triple helix repeat (20 copies) Hexapep PF00132.24 EMD63547.1 - 1.2e-14 53.3 9.0 1e-09 37.7 5.5 3.4 2 1 0 3 3 3 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 EMD63547.1 - 1.2e-12 47.3 10.3 7.4e-10 38.4 4.6 3.1 3 0 0 3 3 3 2 Hexapeptide repeat of succinyl-transferase Mac PF12464.8 EMD63547.1 - 3.7e-10 39.9 0.1 5.9e-10 39.2 0.1 1.3 1 0 0 1 1 1 1 Maltose acetyltransferase ICMT PF04140.14 EMD63548.1 - 3.1e-27 94.8 0.7 6.1e-27 93.9 0.7 1.5 1 0 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 EMD63548.1 - 5e-14 52.6 2.3 5e-14 52.6 2.3 2.1 3 0 0 3 3 3 1 Phospholipid methyltransferase DUF1295 PF06966.12 EMD63548.1 - 2e-06 27.5 1.2 2.7e-06 27.1 1.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) NnrU PF07298.11 EMD63548.1 - 0.00064 19.3 3.4 0.00064 19.3 3.4 1.9 1 1 1 2 2 2 1 NnrU protein SPO22 PF08631.10 EMD63551.1 - 1.6e-05 24.6 1.6 0.0073 15.8 0.0 3.7 3 0 0 3 3 3 2 Meiosis protein SPO22/ZIP4 like DUF3385 PF11865.8 EMD63551.1 - 0.17 11.8 2.8 35 4.2 0.3 4.7 3 1 2 5 5 5 0 Domain of unknown function (DUF3385) HEAT PF02985.22 EMD63551.1 - 0.18 12.2 7.6 3.3 8.2 0.0 5.5 6 0 0 6 6 6 0 HEAT repeat HEAT_2 PF13646.6 EMD63551.1 - 1.4 9.3 4.8 25 5.3 0.0 4.8 6 0 0 6 6 6 0 HEAT repeats HEAT PF02985.22 EMD63552.1 - 1.1e-05 25.3 0.3 0.016 15.4 0.0 4.8 5 0 0 5 5 5 1 HEAT repeat Cnd1 PF12717.7 EMD63552.1 - 0.00014 21.9 0.0 0.061 13.4 0.0 4.0 3 1 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 Nipped-B_C PF12830.7 EMD63552.1 - 0.0044 17.0 0.4 5.2 7.0 0.0 3.2 3 0 0 3 3 3 2 Sister chromatid cohesion C-terminus HEAT_2 PF13646.6 EMD63552.1 - 0.014 15.7 0.3 0.86 10.0 0.0 4.2 6 0 0 6 6 6 0 HEAT repeats HEAT_EZ PF13513.6 EMD63552.1 - 0.15 12.6 4.3 1.1 9.9 0.0 4.4 5 0 0 5 5 5 0 HEAT-like repeat WD40 PF00400.32 EMD63553.1 - 8e-74 241.7 55.5 2.5e-10 40.7 1.0 12.0 12 0 0 12 12 12 10 WD domain, G-beta repeat NACHT PF05729.12 EMD63553.1 - 3.4e-26 92.1 0.0 6.1e-26 91.3 0.0 1.4 1 0 0 1 1 1 1 NACHT domain ANAPC4_WD40 PF12894.7 EMD63553.1 - 1.2e-23 83.2 18.1 0.0051 17.1 0.0 9.6 4 1 7 11 11 11 6 Anaphase-promoting complex subunit 4 WD40 domain HET PF06985.11 EMD63553.1 - 2.8e-11 43.9 11.2 4.6e-10 40.0 0.3 3.0 2 1 1 3 3 3 2 Heterokaryon incompatibility protein (HET) Ge1_WD40 PF16529.5 EMD63553.1 - 9.5e-11 41.2 15.9 0.00014 21.0 0.6 5.6 3 2 1 4 4 4 4 WD40 region of Ge1, enhancer of mRNA-decapping protein CDtoxinA PF03498.14 EMD63553.1 - 1.7e-10 40.6 6.5 0.011 15.4 0.1 5.2 1 1 4 5 5 5 3 Cytolethal distending toxin A/C domain Nup160 PF11715.8 EMD63553.1 - 7.7e-10 38.0 21.9 0.011 14.4 0.0 6.7 2 2 4 7 7 7 4 Nucleoporin Nup120/160 Asp_decarbox PF02261.16 EMD63553.1 - 0.00074 19.4 0.1 0.58 10.1 0.0 4.4 4 2 0 4 4 4 1 Aspartate decarboxylase RicinB_lectin_2 PF14200.6 EMD63553.1 - 0.085 13.6 3.4 14 6.5 0.3 3.7 3 0 0 3 3 3 0 Ricin-type beta-trefoil lectin domain-like AAA_19 PF13245.6 EMD63553.1 - 0.1 12.9 0.0 0.23 11.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain MFS_1 PF07690.16 EMD63554.1 - 1.3e-47 162.4 43.2 1.6e-45 155.5 44.6 2.8 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EMD63554.1 - 1.9e-13 50.1 9.5 1.9e-13 50.1 9.5 2.5 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_4 PF06779.14 EMD63554.1 - 4.6e-05 22.9 7.7 4.6e-05 22.9 7.7 2.4 1 1 1 2 2 2 1 Uncharacterised MFS-type transporter YbfB DUF4245 PF14030.6 EMD63554.1 - 0.09 12.8 2.6 3.4 7.6 0.0 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF4245) Amidase PF01425.21 EMD63555.1 - 1.1e-87 294.9 0.1 1.4e-87 294.6 0.1 1.0 1 0 0 1 1 1 1 Amidase PhetRS_B1 PF18262.1 EMD63555.1 - 0.063 13.5 0.0 0.15 12.3 0.0 1.6 1 0 0 1 1 1 0 Phe-tRNA synthetase beta subunit B1 domain Polysacc_deac_1 PF01522.21 EMD63556.1 - 3.3e-12 46.4 0.0 5.4e-12 45.7 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase dCache_2 PF08269.11 EMD63557.1 - 0.13 11.4 0.5 0.16 11.1 0.5 1.1 1 0 0 1 1 1 0 Cache domain Arginosuc_synth PF00764.19 EMD63558.1 - 1.1e-48 166.5 0.0 1.4e-48 166.2 0.0 1.0 1 0 0 1 1 1 1 Arginosuccinate synthase Asn_synthase PF00733.21 EMD63558.1 - 0.00079 19.2 0.0 0.0016 18.2 0.0 1.4 1 0 0 1 1 1 1 Asparagine synthase QueC PF06508.13 EMD63558.1 - 0.013 15.0 0.0 0.02 14.4 0.0 1.3 1 0 0 1 1 1 0 Queuosine biosynthesis protein QueC 2OG-FeII_Oxy PF03171.20 EMD63559.1 - 3.4e-13 49.9 0.0 5.7e-13 49.2 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 EMD63559.1 - 2.2e-12 47.7 0.0 3.6e-12 47.1 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal TAT_signal PF10518.9 EMD63559.1 - 0.12 12.3 0.5 0.24 11.3 0.5 1.5 1 0 0 1 1 1 0 TAT (twin-arginine translocation) pathway signal sequence CN_hydrolase PF00795.22 EMD63560.1 - 1.2e-32 113.3 0.2 2.5e-32 112.2 0.2 1.5 1 1 0 1 1 1 1 Carbon-nitrogen hydrolase MFS_1 PF07690.16 EMD63561.1 - 1.5e-19 70.1 46.3 1.5e-19 70.1 46.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily tRNA_SAD PF07973.14 EMD63562.1 - 0.00029 20.9 0.2 0.0009 19.3 0.2 1.8 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain tRNA-synt_2c PF01411.19 EMD63562.1 - 0.00045 18.9 0.0 0.00057 18.5 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (A) PX PF00787.24 EMD63563.1 - 3.1e-16 59.3 0.0 1.1e-15 57.6 0.0 1.9 1 0 0 1 1 1 1 PX domain Vps5 PF09325.10 EMD63563.1 - 2.3e-09 37.2 11.5 3.5e-06 26.7 2.6 2.2 2 0 0 2 2 2 2 Vps5 C terminal like Peptidase_C10 PF01640.17 EMD63563.1 - 0.036 14.4 0.0 0.082 13.2 0.0 1.5 1 0 0 1 1 1 0 Peptidase C10 family CAP59_mtransfer PF11735.8 EMD63564.1 - 1.6e-66 224.4 0.0 2.2e-66 224.0 0.0 1.2 1 0 0 1 1 1 1 Cryptococcal mannosyltransferase 1 Zip PF02535.22 EMD63564.1 - 1.1e-26 93.9 13.6 3.1e-20 72.7 7.1 2.1 2 0 0 2 2 2 2 ZIP Zinc transporter DUF4199 PF13858.6 EMD63564.1 - 0.018 15.4 0.0 0.052 14.0 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) DUF3801 PF12687.7 EMD63564.1 - 0.065 13.3 0.0 0.14 12.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3801) GTP_EFTU PF00009.27 EMD63565.1 - 5.5e-57 192.5 0.0 9.2e-57 191.7 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_II PF14492.6 EMD63565.1 - 1.1e-23 83.1 0.0 2.6e-23 81.9 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 EMD63565.1 - 2.8e-16 59.3 0.0 1.6e-08 34.4 0.0 2.5 2 0 0 2 2 2 2 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 EMD63565.1 - 2e-07 31.3 0.1 6.5e-07 29.7 0.1 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_IV PF03764.18 EMD63565.1 - 2.6e-05 24.0 0.3 0.0014 18.4 0.0 2.7 2 0 0 2 2 2 1 Elongation factor G, domain IV RF3_C PF16658.5 EMD63565.1 - 8.1e-05 22.5 0.0 0.00017 21.4 0.0 1.5 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain Vps5 PF09325.10 EMD63566.1 - 1.2e-11 44.6 9.1 2.3e-11 43.7 9.1 1.3 1 0 0 1 1 1 1 Vps5 C terminal like PX PF00787.24 EMD63566.1 - 1.9e-07 31.1 0.0 4.1e-07 30.0 0.0 1.6 1 0 0 1 1 1 1 PX domain NST1 PF13945.6 EMD63566.1 - 0.014 15.5 4.3 0.014 15.5 4.3 2.4 2 0 0 2 2 2 0 Salt tolerance down-regulator TPR_1 PF00515.28 EMD63566.1 - 0.08 12.8 0.1 2.5 8.1 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 EMD63566.1 - 0.4 10.9 1.3 19 5.7 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TFIIA PF03153.13 EMD63566.1 - 2.9 7.8 25.9 5.1 7.0 14.3 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Amidase PF01425.21 EMD63567.1 - 3.1e-52 178.1 0.0 1.3e-50 172.7 0.0 2.2 1 1 0 1 1 1 1 Amidase DDE_1 PF03184.19 EMD63569.1 - 6.4e-30 104.1 0.0 3e-29 101.9 0.0 1.9 2 0 0 2 2 2 1 DDE superfamily endonuclease DDE_3 PF13358.6 EMD63569.1 - 0.01 15.6 0.0 0.031 14.0 0.0 1.8 1 0 0 1 1 1 1 DDE superfamily endonuclease Isy1 PF06246.12 EMD63569.1 - 0.047 13.3 4.5 0.069 12.7 4.5 1.2 1 0 0 1 1 1 0 Isy1-like splicing family RTP1_C1 PF10363.9 EMD63569.1 - 0.062 13.5 0.5 0.12 12.5 0.5 1.4 1 0 0 1 1 1 0 Required for nuclear transport of RNA pol II C-terminus 1 Patatin PF01734.22 EMD63569.1 - 0.18 12.0 0.3 5.5 7.1 0.3 2.2 1 1 0 1 1 1 0 Patatin-like phospholipase DUF4554 PF15091.6 EMD63569.1 - 3.6 6.4 6.4 4.9 5.9 6.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4554) HTH_Tnp_Tc5 PF03221.16 EMD63570.1 - 0.00098 19.1 0.0 0.0028 17.7 0.0 1.8 1 1 0 1 1 1 1 Tc5 transposase DNA-binding domain adh_short_C2 PF13561.6 EMD63571.1 - 2.5e-36 125.4 10.2 1.5e-35 122.9 10.2 1.8 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EMD63571.1 - 3e-25 88.8 4.8 5e-25 88.1 4.8 1.3 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EMD63571.1 - 4.2e-07 30.1 1.3 4.6e-07 29.9 0.4 1.5 2 0 0 2 2 2 1 KR domain DUF1772 PF08592.11 EMD63572.1 - 3.5e-06 27.4 0.3 4.7e-06 27.0 0.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1772) WSC PF01822.19 EMD63574.1 - 4e-07 30.1 10.1 1.1e-06 28.7 10.1 1.8 1 0 0 1 1 1 1 WSC domain SKG6 PF08693.10 EMD63574.1 - 0.00074 18.9 0.8 0.0019 17.5 0.8 1.7 1 0 0 1 1 1 1 Transmembrane alpha-helix domain PTP_tm PF18861.1 EMD63574.1 - 0.0014 18.7 0.6 0.0024 17.9 0.6 1.3 1 0 0 1 1 1 1 Transmembrane domain of protein tyrosine phosphatase, receptor type J DUF5385 PF17359.2 EMD63574.1 - 0.02 14.5 0.0 0.031 13.8 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5385) CcmD PF04995.14 EMD63574.1 - 0.074 13.1 0.3 0.14 12.2 0.3 1.5 1 0 0 1 1 1 0 Heme exporter protein D (CcmD) Apt1 PF10351.9 EMD63574.1 - 0.11 11.4 1.5 0.12 11.2 1.5 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain EphA2_TM PF14575.6 EMD63574.1 - 0.13 13.1 0.0 0.41 11.6 0.0 1.8 2 0 0 2 2 1 0 Ephrin type-A receptor 2 transmembrane domain Syndecan PF01034.20 EMD63574.1 - 0.16 11.9 0.1 0.3 11.0 0.1 1.4 1 0 0 1 1 1 0 Syndecan domain FeoB_associated PF12669.7 EMD63574.1 - 0.22 11.9 0.0 0.22 11.9 0.0 2.3 2 0 0 2 2 2 0 FeoB-associated Cys-rich membrane protein DUF2207 PF09972.9 EMD63574.1 - 0.25 10.1 0.0 0.35 9.6 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Ndc1_Nup PF09531.10 EMD63574.1 - 0.3 9.7 7.1 0.39 9.4 7.1 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup F-box-like PF12937.7 EMD63575.1 - 2.3e-06 27.4 0.0 6.9e-06 25.9 0.0 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EMD63575.1 - 3.6 7.6 5.3 0.83 9.6 0.1 2.7 3 1 0 3 3 3 0 F-box domain ArfGap PF01412.18 EMD63576.1 - 2.5e-30 104.9 0.2 5.5e-30 103.8 0.2 1.6 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf MMR_HSR1 PF01926.23 EMD63578.1 - 1.1e-13 51.2 0.0 2.1e-13 50.3 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EMD63578.1 - 0.0012 18.4 0.3 0.0022 17.5 0.3 1.6 1 1 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EMD63578.1 - 0.0027 17.6 0.4 0.0097 15.8 0.4 2.0 1 1 0 1 1 1 1 RsgA GTPase MeaB PF03308.16 EMD63578.1 - 0.012 14.7 0.3 0.023 13.7 0.2 1.5 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Dynamin_N PF00350.23 EMD63578.1 - 0.012 15.7 0.4 0.099 12.7 0.1 2.2 1 1 1 2 2 2 0 Dynamin family AAA_16 PF13191.6 EMD63578.1 - 0.042 14.2 0.1 0.08 13.3 0.1 1.6 1 0 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.27 EMD63578.1 - 0.044 14.3 0.0 0.07 13.6 0.0 1.4 1 0 0 1 1 1 0 ABC transporter AAA_18 PF13238.6 EMD63578.1 - 0.06 13.9 0.3 0.06 13.9 0.3 2.0 2 0 0 2 2 2 0 AAA domain RuvB_N PF05496.12 EMD63578.1 - 0.12 12.2 0.0 0.18 11.6 0.0 1.2 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_29 PF13555.6 EMD63578.1 - 0.12 12.1 0.0 0.25 11.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Roc PF08477.13 EMD63578.1 - 0.14 12.4 0.1 0.24 11.6 0.1 1.3 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase HET PF06985.11 EMD63580.1 - 2.6e-17 63.5 0.0 2.9e-17 63.4 0.0 1.0 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) SAP PF02037.27 EMD63581.1 - 6.3e-10 38.6 0.1 1.2e-09 37.7 0.1 1.5 1 0 0 1 1 1 1 SAP domain RSB_motif PF16294.5 EMD63581.1 - 9.2e-08 32.3 0.1 9.2e-08 32.3 0.1 3.8 3 1 1 4 4 4 1 RNSP1-SAP18 binding (RSB) motif Rho_N PF07498.12 EMD63581.1 - 0.013 15.4 0.1 0.028 14.3 0.1 1.5 1 0 0 1 1 1 0 Rho termination factor, N-terminal domain HeH PF12949.7 EMD63581.1 - 0.061 13.0 0.0 0.13 12.0 0.0 1.6 1 0 0 1 1 1 0 HeH/LEM domain Fungal_trans_2 PF11951.8 EMD63582.1 - 4.7e-16 58.6 0.0 3.1e-15 55.9 0.0 1.9 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD63582.1 - 4.3e-10 39.5 9.8 7.1e-10 38.8 9.8 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MRP-L46 PF11788.8 EMD63584.1 - 2e-38 131.8 0.1 4.4e-38 130.7 0.1 1.6 1 0 0 1 1 1 1 39S mitochondrial ribosomal protein L46 Cpn60_TCP1 PF00118.24 EMD63585.1 - 1.1e-149 499.2 14.2 1.3e-149 499.0 14.2 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family EAL PF00563.20 EMD63585.1 - 0.0024 17.4 0.0 0.0054 16.3 0.0 1.5 1 0 0 1 1 1 1 EAL domain TetR_C_14 PF17754.1 EMD63585.1 - 0.013 15.5 2.5 0.15 12.0 0.6 2.4 2 0 0 2 2 2 0 MftR C-terminal domain PrpR_N PF06506.11 EMD63585.1 - 0.021 14.4 0.7 0.058 13.0 0.2 2.0 2 0 0 2 2 2 0 Propionate catabolism activator Nitro_FeMo-Co PF02579.17 EMD63585.1 - 0.027 14.8 0.0 0.12 12.7 0.0 2.1 1 0 0 1 1 1 0 Dinitrogenase iron-molybdenum cofactor Abhydrolase_6 PF12697.7 EMD63588.1 - 1.1e-11 45.8 2.1 1.4e-11 45.4 2.1 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EMD63588.1 - 0.043 13.5 0.0 0.061 12.9 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EMD63588.1 - 0.05 12.9 0.0 0.077 12.2 0.0 1.2 1 0 0 1 1 1 0 Serine aminopeptidase, S33 DUF3621 PF12285.8 EMD63588.1 - 0.085 13.2 0.2 0.19 12.1 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3621) KdpC PF02669.15 EMD63589.1 - 0.05 13.4 0.1 0.43 10.4 0.0 2.2 2 0 0 2 2 2 0 K+-transporting ATPase, c chain zf-CCCH PF00642.24 EMD63590.1 - 1.3e-08 34.5 2.8 2.5e-08 33.6 2.8 1.5 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-C3HC4_3 PF13920.6 EMD63590.1 - 7.6e-08 32.1 6.8 1.3e-07 31.3 6.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EMD63590.1 - 4.6e-07 29.7 6.9 9.5e-07 28.8 6.9 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EMD63590.1 - 1.3e-06 28.1 10.8 2.5e-06 27.3 10.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EMD63590.1 - 1.8e-06 27.7 9.1 3.6e-06 26.7 9.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EMD63590.1 - 3.8e-06 26.8 9.2 6.5e-06 26.0 9.2 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_10 PF16685.5 EMD63590.1 - 6.7e-06 26.2 4.4 6.7e-06 26.2 4.4 1.7 2 0 0 2 2 1 1 zinc RING finger of MSL2 zf_CCCH_4 PF18345.1 EMD63590.1 - 1.7e-05 24.7 6.2 3.3e-05 23.8 6.2 1.5 1 0 0 1 1 1 1 Zinc finger domain zf-RING_2 PF13639.6 EMD63590.1 - 0.00011 22.4 8.0 0.00022 21.5 8.0 1.5 1 0 0 1 1 1 1 Ring finger domain zf-CCCH_4 PF18044.1 EMD63590.1 - 0.00018 21.2 2.6 0.00018 21.2 2.6 1.7 2 0 0 2 2 1 1 CCCH-type zinc finger Prok-RING_4 PF14447.6 EMD63590.1 - 0.00072 19.4 5.8 0.0014 18.5 5.8 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 EMD63590.1 - 0.047 13.9 8.7 0.12 12.6 8.7 1.7 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-CCCH_2 PF14608.6 EMD63590.1 - 0.077 13.5 3.6 0.16 12.4 3.6 1.6 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger Peptidase_Prp PF04327.12 EMD63590.1 - 0.089 13.0 0.3 0.33 11.2 0.0 1.9 2 0 0 2 2 2 0 Cysteine protease Prp zf-Nse PF11789.8 EMD63590.1 - 0.15 11.9 2.0 0.26 11.2 2.0 1.3 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-rbx1 PF12678.7 EMD63590.1 - 0.18 12.1 4.8 0.41 11.0 4.8 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger domain Mcp5_PH PF12814.7 EMD63591.1 - 3.8e-47 159.4 0.1 8.3e-47 158.3 0.1 1.6 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology PH PF00169.29 EMD63591.1 - 3.6e-05 24.2 0.0 0.00012 22.6 0.0 1.9 2 0 0 2 2 2 1 PH domain COMM_domain PF07258.14 EMD63591.1 - 0.043 13.9 0.9 0.16 12.1 0.9 2.0 1 0 0 1 1 1 0 COMM domain SbsC_C PF18058.1 EMD63591.1 - 0.085 13.1 1.7 0.31 11.3 0.1 2.6 2 0 0 2 2 2 0 SbsC C-terminal domain Isy1 PF06246.12 EMD63592.1 - 1.1e-91 306.9 3.8 1.3e-91 306.7 3.8 1.0 1 0 0 1 1 1 1 Isy1-like splicing family UPF0113 PF03657.13 EMD63593.1 - 4.3e-26 91.0 0.0 8.8e-26 90.0 0.0 1.5 2 0 0 2 2 2 1 UPF0113 PUA domain UPF0113_N PF17833.1 EMD63593.1 - 1.6e-25 89.4 0.0 2.2e-25 89.0 0.0 1.2 1 0 0 1 1 1 1 UPF0113 Pre-PUA domain PUA PF01472.20 EMD63593.1 - 0.019 15.0 0.0 0.029 14.3 0.0 1.3 1 0 0 1 1 1 0 PUA domain NOC3p PF07540.11 EMD63594.1 - 1.4e-32 112.0 2.5 2.5e-32 111.2 0.8 2.4 2 0 0 2 2 2 1 Nucleolar complex-associated protein CBF PF03914.17 EMD63594.1 - 7.1e-27 94.5 0.0 7.1e-27 94.5 0.0 2.0 2 1 0 2 2 2 1 CBF/Mak21 family Tyrosinase PF00264.20 EMD63595.1 - 2.2e-44 152.4 0.1 2.8e-44 152.0 0.1 1.1 1 0 0 1 1 1 1 Common central domain of tyrosinase Lectin_leg-like PF03388.13 EMD63596.1 - 3e-66 223.1 0.0 4e-66 222.6 0.0 1.2 1 0 0 1 1 1 1 Legume-like lectin family Bact_lectin PF18483.1 EMD63596.1 - 3.9e-08 33.6 0.3 6.3e-08 32.9 0.1 1.5 1 1 1 2 2 2 1 Bacterial lectin Lectin_legB PF00139.19 EMD63596.1 - 0.00017 21.2 0.0 0.017 14.7 0.0 2.2 1 1 0 1 1 1 1 Legume lectin domain zf-Tim10_DDP PF02953.15 EMD63597.1 - 2.4e-24 84.7 1.7 2.9e-24 84.5 1.7 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger Endonuclease_NS PF01223.23 EMD63598.1 - 4.4e-65 219.7 0.0 5.3e-65 219.4 0.0 1.1 1 0 0 1 1 1 1 DNA/RNA non-specific endonuclease Tir_receptor_C PF07489.11 EMD63598.1 - 0.017 15.1 4.2 0.028 14.4 4.2 1.2 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) C-terminus ThiF PF00899.21 EMD63599.1 - 2.1e-40 138.6 0.0 3.6e-40 137.9 0.0 1.3 1 0 0 1 1 1 1 ThiF family Sacchrp_dh_NADP PF03435.18 EMD63599.1 - 0.00017 21.8 0.3 0.00072 19.8 0.3 2.0 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain TrkA_N PF02254.18 EMD63599.1 - 0.0026 18.0 0.1 0.03 14.6 0.0 2.7 3 0 0 3 3 3 1 TrkA-N domain NAD_binding_7 PF13241.6 EMD63599.1 - 0.086 13.3 0.2 2.6 8.5 0.0 2.9 2 1 0 2 2 2 0 Putative NAD(P)-binding UDPG_MGDP_dh_N PF03721.14 EMD63599.1 - 0.15 11.6 0.0 0.32 10.5 0.0 1.6 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain ADH_N PF08240.12 EMD63600.1 - 9.8e-24 83.3 4.1 1.5e-23 82.8 4.1 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EMD63600.1 - 2.9e-20 72.6 0.0 4.7e-20 71.9 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EMD63600.1 - 1e-07 33.1 0.0 1.9e-07 32.2 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 EMD63600.1 - 0.004 16.5 0.1 0.0069 15.8 0.1 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 EMD63600.1 - 0.0092 15.3 0.0 0.016 14.5 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Abhydrolase_1 PF00561.20 EMD63601.1 - 3.2e-14 53.2 0.1 3.3e-13 49.9 0.1 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EMD63601.1 - 1.3e-11 44.2 0.0 6.5e-11 41.9 0.0 1.9 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EMD63601.1 - 8.4e-07 29.8 0.0 1.2e-06 29.3 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S15 PF02129.18 EMD63601.1 - 0.0025 17.5 0.0 0.004 16.8 0.0 1.3 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) DLH PF01738.18 EMD63601.1 - 0.0064 16.1 0.0 0.23 11.0 0.0 2.1 2 0 0 2 2 2 1 Dienelactone hydrolase family PhoPQ_related PF10142.9 EMD63601.1 - 0.015 14.0 0.1 0.038 12.7 0.1 1.6 2 0 0 2 2 2 0 PhoPQ-activated pathogenicity-related protein Ndr PF03096.14 EMD63601.1 - 0.02 13.6 0.0 1.1 7.9 0.0 2.2 2 0 0 2 2 2 0 Ndr family Abhydrolase_2 PF02230.16 EMD63601.1 - 0.029 14.2 0.1 0.7 9.7 0.0 2.2 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Ank_4 PF13637.6 EMD63603.1 - 1.2e-09 38.5 0.0 5.4e-08 33.2 0.0 2.0 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EMD63603.1 - 2.4e-07 31.2 0.1 1.1e-06 29.2 0.1 1.9 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 EMD63603.1 - 3.1e-07 30.5 0.0 6.1e-05 23.3 0.0 2.9 3 0 0 3 3 3 1 Ankyrin repeat Ank_3 PF13606.6 EMD63603.1 - 0.0018 18.6 0.0 0.03 14.8 0.0 2.5 3 0 0 3 3 3 1 Ankyrin repeat Ank_5 PF13857.6 EMD63603.1 - 0.011 16.0 0.0 0.015 15.6 0.0 1.3 1 0 0 1 1 1 0 Ankyrin repeats (many copies) PNP_UDP_1 PF01048.20 EMD63604.1 - 1.5e-12 47.3 0.3 3.1e-12 46.2 0.3 1.5 1 0 0 1 1 1 1 Phosphorylase superfamily Ank_4 PF13637.6 EMD63604.1 - 6.9e-10 39.3 0.1 3.9e-06 27.3 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EMD63604.1 - 1.2e-06 29.0 0.0 6.2e-06 26.7 0.0 2.2 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.30 EMD63604.1 - 3e-06 27.4 0.0 0.00089 19.6 0.0 2.8 2 0 0 2 2 2 1 Ankyrin repeat AAA_16 PF13191.6 EMD63604.1 - 6.2e-06 26.7 0.0 1.9e-05 25.1 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain NACHT PF05729.12 EMD63604.1 - 3.8e-05 23.7 0.0 8.3e-05 22.6 0.0 1.6 1 1 0 1 1 1 1 NACHT domain Ank_3 PF13606.6 EMD63604.1 - 0.00025 21.2 0.0 0.37 11.5 0.0 3.0 2 0 0 2 2 2 2 Ankyrin repeat AAA_22 PF13401.6 EMD63604.1 - 0.0038 17.5 0.0 0.0089 16.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain Ank_5 PF13857.6 EMD63604.1 - 0.018 15.4 0.1 0.16 12.3 0.0 2.5 1 1 1 2 2 2 0 Ankyrin repeats (many copies) RNA_helicase PF00910.22 EMD63604.1 - 0.18 12.2 0.0 0.55 10.6 0.0 1.8 2 0 0 2 2 2 0 RNA helicase PH_10 PF15411.6 EMD63605.1 - 3.5e-27 95.1 0.1 6.1e-27 94.3 0.1 1.4 1 0 0 1 1 1 1 Pleckstrin homology domain VWA PF00092.28 EMD63605.1 - 9.4e-14 52.0 0.0 1.4e-13 51.4 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 EMD63605.1 - 6e-09 36.0 0.0 1.7e-08 34.5 0.0 1.8 1 1 0 1 1 1 1 von Willebrand factor type A domain zf-RING_2 PF13639.6 EMD63605.1 - 6.5e-05 23.2 8.1 0.00012 22.4 8.1 1.4 1 0 0 1 1 1 1 Ring finger domain Zn_ribbon_17 PF17120.5 EMD63605.1 - 0.0056 16.3 5.4 0.0056 16.3 5.4 2.0 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type zf-RING_5 PF14634.6 EMD63605.1 - 0.011 15.7 8.4 0.019 14.9 8.4 1.4 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_2 PF13923.6 EMD63605.1 - 0.011 15.5 7.0 0.022 14.6 7.0 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EMD63605.1 - 0.019 14.7 4.3 0.04 13.7 4.3 1.6 1 0 0 1 1 1 0 RING-like zinc finger zf-rbx1 PF12678.7 EMD63605.1 - 0.04 14.2 4.2 0.085 13.2 4.2 1.5 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 EMD63605.1 - 0.12 12.3 8.7 0.21 11.5 8.7 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING-like PF08746.11 EMD63605.1 - 0.14 12.5 8.0 0.25 11.7 8.0 1.5 1 0 0 1 1 1 0 RING-like domain zf-UDP PF14569.6 EMD63605.1 - 0.16 12.1 1.9 0.29 11.3 1.9 1.4 1 0 0 1 1 1 0 Zinc-binding RING-finger Prok-RING_4 PF14447.6 EMD63605.1 - 0.36 10.7 5.1 0.65 9.9 5.1 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 EF-hand_1 PF00036.32 EMD63606.1 - 1.1e-41 137.3 12.9 7.8e-10 37.6 0.9 4.1 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 EMD63606.1 - 3.5e-36 123.5 5.8 3.9e-19 68.9 2.2 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 EMD63606.1 - 6.8e-35 118.7 11.4 2.3e-15 56.1 0.6 4.0 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 EMD63606.1 - 2.1e-30 102.0 9.5 1.9e-09 36.7 0.2 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 EMD63606.1 - 6.5e-26 88.6 10.6 2.6e-06 26.7 0.3 4.3 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.6 EMD63606.1 - 1.5e-16 60.5 0.4 2.3e-09 37.4 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 EMD63606.1 - 3.4e-09 36.6 1.9 0.00075 19.4 0.2 2.3 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 EMD63606.1 - 5.6e-09 36.3 0.2 0.0016 18.7 0.1 2.1 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region UPF0154 PF03672.13 EMD63606.1 - 9.9e-07 28.7 0.0 0.0077 16.2 0.0 3.0 2 1 1 3 3 3 2 Uncharacterised protein family (UPF0154) EFhand_Ca_insen PF08726.10 EMD63606.1 - 5.8e-06 26.3 1.6 2.3e-05 24.4 0.2 2.3 2 1 0 2 2 2 1 Ca2+ insensitive EF hand EF-hand_11 PF08976.11 EMD63606.1 - 9.1e-05 23.3 0.2 0.0022 18.8 0.1 2.0 1 1 1 2 2 2 1 EF-hand domain TerB PF05099.13 EMD63606.1 - 0.00012 22.0 0.3 0.35 10.8 0.0 2.2 1 1 1 2 2 2 2 Tellurite resistance protein TerB Caleosin PF05042.13 EMD63606.1 - 0.00045 20.2 1.8 0.44 10.5 0.0 3.5 1 1 3 4 4 4 1 Caleosin related protein RNA_pol_Rpb4 PF03874.16 EMD63606.1 - 0.00062 20.1 0.8 0.66 10.3 0.1 2.7 2 1 1 3 3 3 2 RNA polymerase Rpb4 DUF3349 PF11829.8 EMD63606.1 - 0.0014 19.3 0.4 3.7 8.4 0.0 2.9 1 1 2 3 3 3 1 Protein of unknown function (DUF3349) Dockerin_1 PF00404.18 EMD63606.1 - 0.0053 16.9 7.0 0.38 11.0 0.8 2.9 1 1 2 3 3 3 2 Dockerin type I domain DUF5580 PF17743.1 EMD63606.1 - 0.006 15.2 0.0 0.0062 15.1 0.0 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5580) SurA_N_2 PF13623.6 EMD63606.1 - 0.0091 15.9 0.9 0.32 10.9 0.1 2.2 1 1 1 2 2 2 1 SurA N-terminal domain EF-hand_14 PF17959.1 EMD63606.1 - 0.012 16.0 0.5 6.2 7.2 0.1 2.4 1 1 1 2 2 2 0 EF-hand domain Poly_export PF02563.16 EMD63606.1 - 0.023 14.9 0.0 0.18 12.1 0.0 2.5 2 1 0 2 2 2 0 Polysaccharide biosynthesis/export protein DUF4497 PF14924.6 EMD63606.1 - 0.036 14.5 0.0 8.7 6.9 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4497) RuvA_C PF07499.13 EMD63606.1 - 0.058 13.9 0.1 8.5 6.9 0.0 3.0 3 0 0 3 3 3 0 RuvA, C-terminal domain MotA_activ PF09114.10 EMD63606.1 - 0.061 13.4 0.3 1.2 9.3 0.0 2.3 1 1 0 2 2 2 0 Transcription factor MotA, activation domain dCache_2 PF08269.11 EMD63606.1 - 0.066 12.4 0.1 1.1 8.4 0.1 2.1 1 1 1 2 2 2 0 Cache domain DUF5132 PF17195.4 EMD63606.1 - 0.15 12.2 0.5 21 5.3 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF5132) RloB PF13707.6 EMD63606.1 - 0.16 12.2 1.1 0.76 9.9 0.2 2.0 1 1 1 2 2 2 0 RloB-like protein SNARE PF05739.19 EMD63607.1 - 3.6e-12 46.1 0.4 9.5e-12 44.7 0.4 1.8 1 0 0 1 1 1 1 SNARE domain Syntaxin_2 PF14523.6 EMD63607.1 - 0.0016 18.8 9.5 0.013 15.8 5.3 2.4 2 0 0 2 2 2 1 Syntaxin-like protein EBV-NA3 PF05009.12 EMD63607.1 - 0.0022 17.6 0.1 0.0035 16.9 0.1 1.2 1 0 0 1 1 1 1 Epstein-Barr virus nuclear antigen 3 (EBNA-3) Syntaxin PF00804.25 EMD63607.1 - 0.0084 15.8 14.3 0.086 12.5 1.2 2.3 2 0 0 2 2 2 2 Syntaxin Cbl_N PF02262.16 EMD63607.1 - 0.3 11.1 2.4 0.43 10.6 0.5 2.2 2 1 0 2 2 2 0 CBL proto-oncogene N-terminal domain 1 MCPsignal PF00015.21 EMD63607.1 - 0.61 9.9 7.9 0.29 10.9 0.2 2.6 2 1 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain SlyX PF04102.12 EMD63607.1 - 4 8.1 17.6 2.4 8.8 0.4 3.7 2 2 1 3 3 3 0 SlyX DUF829 PF05705.14 EMD63609.1 - 2.6e-52 178.1 0.0 3.1e-52 177.9 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF829) Mpv17_PMP22 PF04117.12 EMD63610.1 - 4.5e-17 62.0 0.5 1.1e-16 60.8 0.5 1.7 1 0 0 1 1 1 1 Mpv17 / PMP22 family Copper-bind PF00127.20 EMD63611.1 - 0.00016 22.0 0.3 0.00028 21.3 0.3 1.3 1 0 0 1 1 1 1 Copper binding proteins, plastocyanin/azurin family Cu_bind_like PF02298.17 EMD63611.1 - 0.015 15.3 0.6 0.14 12.2 0.5 2.3 1 1 0 1 1 1 0 Plastocyanin-like domain Cerato-platanin PF07249.12 EMD63612.1 - 8.9e-60 200.0 1.3 1.1e-59 199.7 1.3 1.1 1 0 0 1 1 1 1 Cerato-platanin PsbY PF06298.11 EMD63612.1 - 0.09 12.7 0.8 0.21 11.5 0.8 1.6 1 0 0 1 1 1 0 Photosystem II protein Y (PsbY) Ecl1 PF12855.7 EMD63614.1 - 2.3e-37 129.8 20.2 2.3e-37 129.8 20.2 2.9 3 0 0 3 3 3 1 ECL1/2/3 zinc binding proteins zf-MYND PF01753.18 EMD63614.1 - 0.0068 16.5 1.6 0.014 15.4 1.6 1.5 1 0 0 1 1 1 1 MYND finger zf-FLZ PF04570.14 EMD63614.1 - 0.33 10.5 2.4 1.1 8.8 2.4 1.8 1 1 0 1 1 1 0 zinc-finger of the FCS-type, C2-C2 DUF2256 PF10013.9 EMD63614.1 - 2 8.6 4.4 1.4 9.1 0.7 2.1 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2256) Methyltransf_16 PF10294.9 EMD63616.1 - 1.5e-19 70.4 0.0 2.5e-19 69.7 0.0 1.3 1 0 0 1 1 1 1 Lysine methyltransferase PrmA PF06325.13 EMD63616.1 - 1e-05 25.1 0.2 1.5e-05 24.5 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 EMD63616.1 - 0.00048 19.7 0.1 0.001 18.7 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.6 EMD63616.1 - 0.0061 17.2 0.1 0.014 16.1 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase domain Ribosomal_S24e PF01282.19 EMD63617.1 - 3.7e-35 119.7 0.2 3.7e-35 119.7 0.2 1.5 2 0 0 2 2 2 1 Ribosomal protein S24e YL1 PF05764.13 EMD63618.1 - 2.7e-58 198.0 33.1 2.7e-58 198.0 33.1 2.0 2 0 0 2 2 2 1 YL1 nuclear protein YL1_C PF08265.11 EMD63618.1 - 3.1e-10 39.6 0.1 5.5e-10 38.8 0.1 1.4 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain Thioredoxin_3 PF13192.6 EMD63618.1 - 0.095 12.8 0.0 0.3 11.2 0.0 1.9 2 0 0 2 2 2 0 Thioredoxin domain COPI_C PF06957.11 EMD63618.1 - 2.4 6.8 8.4 4.8 5.8 8.4 1.4 1 0 0 1 1 1 0 Coatomer (COPI) alpha subunit C-terminus PUF PF00806.19 EMD63620.1 - 3.5e-24 83.1 0.0 0.00017 21.1 0.0 6.2 6 0 0 6 6 6 5 Pumilio-family RNA binding repeat RRM_1 PF00076.22 EMD63620.1 - 4.2e-12 45.7 0.0 8.4e-12 44.7 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EMD63620.1 - 0.041 13.5 0.0 0.082 12.5 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Autophagy_N PF03986.13 EMD63621.1 - 5.3e-44 149.5 0.2 9.4e-44 148.7 0.0 1.5 2 0 0 2 2 2 1 Autophagocytosis associated protein (Atg3), N-terminal domain Autophagy_C PF10381.9 EMD63621.1 - 5.8e-16 57.7 0.6 9.9e-16 56.9 0.6 1.4 1 0 0 1 1 1 1 Autophagocytosis associated protein C-terminal Autophagy_act_C PF03987.15 EMD63621.1 - 2.2e-15 57.0 0.1 3.9e-15 56.2 0.1 1.4 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain TPPK_C PF12555.8 EMD63622.1 - 0.23 11.5 0.5 0.36 10.9 0.5 1.3 1 0 0 1 1 1 0 Thiamine pyrophosphokinase C terminal DNA_pol_B_thumb PF14791.6 EMD63623.1 - 1e-20 73.7 0.0 2.2e-20 72.6 0.0 1.6 1 0 0 1 1 1 1 DNA polymerase beta thumb DNA_pol_B_palm PF14792.6 EMD63623.1 - 2.6e-18 66.3 0.1 5.9e-18 65.1 0.1 1.6 1 1 0 1 1 1 1 DNA polymerase beta palm DNA_pol_lambd_f PF10391.9 EMD63623.1 - 1.6e-16 59.8 0.9 4.6e-16 58.4 0.9 1.8 1 0 0 1 1 1 1 Fingers domain of DNA polymerase lambda HHH_8 PF14716.6 EMD63623.1 - 7.8e-08 32.6 0.0 9.2e-07 29.1 0.0 2.7 3 0 0 3 3 3 1 Helix-hairpin-helix domain HHH_5 PF14520.6 EMD63623.1 - 0.03 14.9 0.0 1.5 9.5 0.0 2.6 2 0 0 2 2 2 0 Helix-hairpin-helix domain MG3 PF17791.1 EMD63623.1 - 0.064 13.5 0.0 0.14 12.4 0.0 1.5 1 0 0 1 1 1 0 Macroglobulin domain MG3 N_Asn_amidohyd PF14736.6 EMD63623.1 - 0.1 11.7 0.0 0.17 11.0 0.0 1.3 1 0 0 1 1 1 0 Protein N-terminal asparagine amidohydrolase NTP_transf_2 PF01909.23 EMD63623.1 - 0.13 12.6 0.0 0.33 11.3 0.0 1.7 1 0 0 1 1 1 0 Nucleotidyltransferase domain Sa_NUDIX PF18167.1 EMD63624.1 - 0.16 11.7 0.1 0.25 11.1 0.1 1.2 1 0 0 1 1 1 0 SMODS-associated NUDIX domain DUF4336 PF14234.6 EMD63625.1 - 9.7e-18 64.4 0.1 1.4e-13 50.7 0.1 2.5 1 1 1 2 2 2 2 Domain of unknown function (DUF4336) RNase_PH PF01138.21 EMD63626.1 - 2e-20 73.6 0.0 3e-20 73.1 0.0 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 EMD63626.1 - 7.2e-11 42.0 0.0 1.4e-10 41.0 0.0 1.5 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 Cwf_Cwc_15 PF04889.12 EMD63627.1 - 2.7e-81 272.9 21.7 3.6e-81 272.5 21.7 1.2 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein DUF4407 PF14362.6 EMD63627.1 - 0.4 10.0 11.0 0.59 9.4 11.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) CDC45 PF02724.14 EMD63627.1 - 1.6 6.9 18.8 1.8 6.7 18.8 1.1 1 0 0 1 1 1 0 CDC45-like protein PI3_PI4_kinase PF00454.27 EMD63629.1 - 1.2e-33 117.0 0.0 7.7e-33 114.3 0.0 2.0 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase Pik1 PF11522.8 EMD63629.1 - 6.6e-19 67.6 0.3 1.5e-18 66.5 0.3 1.6 1 0 0 1 1 1 1 Yeast phosphatidylinositol-4-OH kinase Pik1 DUF4135 PF13575.6 EMD63629.1 - 0.13 11.6 0.0 0.24 10.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) DUF155 PF02582.14 EMD63630.1 - 1.3e-51 175.2 1.0 2.1e-51 174.5 1.0 1.3 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 UPF0449 PF15136.6 EMD63630.1 - 0.12 12.9 0.0 0.29 11.6 0.0 1.6 1 0 0 1 1 1 0 Uncharacterised protein family UPF0449 Peptidase_M14 PF00246.24 EMD63631.1 - 3e-74 250.4 0.0 3.8e-74 250.1 0.0 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase Sec7 PF01369.20 EMD63632.1 - 7.4e-33 113.8 0.0 1.2e-32 113.0 0.0 1.3 1 0 0 1 1 1 1 Sec7 domain PH_9 PF15410.6 EMD63632.1 - 1.1e-06 29.1 0.1 2.3e-06 28.0 0.1 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 EMD63632.1 - 4.6e-05 23.9 0.1 9.7e-05 22.8 0.1 1.6 1 0 0 1 1 1 1 PH domain DUF1351 PF07083.11 EMD63632.1 - 0.17 11.6 0.3 0.39 10.5 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1351) Clr5 PF14420.6 EMD63634.1 - 1.4e-17 63.6 0.1 2.8e-17 62.7 0.1 1.5 1 0 0 1 1 1 1 Clr5 domain MFS_1 PF07690.16 EMD63636.1 - 1.5e-17 63.6 40.9 7.1e-16 58.1 35.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EMD63636.1 - 0.00018 20.5 32.1 0.0038 16.1 25.2 3.0 1 1 1 2 2 2 2 Sugar (and other) transporter F-box-like PF12937.7 EMD63637.1 - 4.7e-07 29.6 0.7 2.2e-06 27.4 0.7 2.2 1 1 0 1 1 1 1 F-box-like F-box PF00646.33 EMD63637.1 - 0.0045 16.8 1.1 0.056 13.3 0.4 3.0 2 1 0 2 2 2 1 F-box domain Glyco_hydro_43 PF04616.14 EMD63638.1 - 1.2e-29 103.6 4.9 1.7e-29 103.0 4.9 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 GH43_C2 PF17851.1 EMD63638.1 - 1.7e-25 89.9 0.0 2.5e-25 89.4 0.0 1.3 1 0 0 1 1 1 1 Beta xylosidase C-terminal Concanavalin A-like domain Aminotran_5 PF00266.19 EMD63639.1 - 1.9e-58 198.2 0.0 4.7e-58 196.9 0.0 1.5 1 1 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 EMD63639.1 - 1.2e-06 27.4 0.0 1.9e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 EMD63639.1 - 0.00039 19.7 0.0 0.00065 19.0 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II DUF2985 PF11204.8 EMD63639.1 - 0.099 12.8 0.0 0.2 11.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2985) Tyrosinase PF00264.20 EMD63643.1 - 1.2e-50 172.9 0.1 1.6e-50 172.5 0.1 1.1 1 0 0 1 1 1 1 Common central domain of tyrosinase ALMT PF11744.8 EMD63644.1 - 6.8 5.4 6.7 10 4.8 6.7 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF2570 PF10828.8 EMD63645.1 - 0.0042 16.9 11.2 0.023 14.5 0.5 2.6 2 1 0 2 2 2 2 Protein of unknown function (DUF2570) Uso1_p115_C PF04871.13 EMD63645.1 - 0.018 15.4 1.5 0.018 15.4 1.5 2.2 2 0 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region O-antigen_lig PF13425.6 EMD63645.1 - 0.44 9.3 0.6 0.52 9.0 0.6 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein VPS38 PF17649.1 EMD63645.1 - 0.66 8.8 2.6 0.94 8.3 2.6 1.2 1 0 0 1 1 1 0 Vacuolar protein sorting 38 Methyltransf_2 PF00891.18 EMD63646.1 - 2.1e-24 86.0 0.0 3.2e-24 85.4 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_25 PF13649.6 EMD63646.1 - 3.1e-05 24.6 0.0 0.00018 22.2 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 EMD63646.1 - 0.015 14.6 0.0 0.026 13.8 0.0 1.4 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family MarR_2 PF12802.7 EMD63646.1 - 0.073 13.0 0.0 0.29 11.0 0.0 2.0 2 0 0 2 2 2 0 MarR family Methyltransf_31 PF13847.6 EMD63646.1 - 0.079 12.8 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain MutS_V PF00488.21 EMD63647.1 - 1.2e-81 273.2 0.2 2.4e-81 272.3 0.2 1.5 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 EMD63647.1 - 8.8e-37 127.2 1.9 1.3e-36 126.6 0.9 1.9 2 0 0 2 2 2 1 MutS domain III MutS_II PF05188.17 EMD63647.1 - 1.6e-20 73.7 3.3 7.5e-20 71.6 0.0 3.2 3 0 0 3 3 3 1 MutS domain II MutS_IV PF05190.18 EMD63647.1 - 7.7e-19 67.8 3.5 2e-18 66.5 3.5 1.8 1 0 0 1 1 1 1 MutS family domain IV MutS_I PF01624.20 EMD63647.1 - 2.4e-18 66.4 0.1 2.6e-17 63.1 0.0 2.4 2 0 0 2 2 2 1 MutS domain I ABC_tran PF00005.27 EMD63647.1 - 0.042 14.4 0.6 7.2 7.1 0.0 2.9 2 0 0 2 2 2 0 ABC transporter IFN-gamma PF00714.17 EMD63647.1 - 0.16 11.8 2.4 0.21 11.4 0.0 2.4 3 0 0 3 3 3 0 Interferon gamma DUF148 PF02520.17 EMD63647.1 - 0.46 10.6 9.7 1.1 9.4 0.7 3.3 4 0 0 4 4 4 0 Domain of unknown function DUF148 KinB_sensor PF16767.5 EMD63647.1 - 0.5 10.8 4.1 0.38 11.2 0.1 2.7 3 0 0 3 3 3 0 Sensor domain of alginate biosynthesis sensor protein KinB Ist1 PF03398.14 EMD63648.1 - 3.5e-55 186.4 6.3 4.7e-55 186.0 6.3 1.2 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway TFIIA PF03153.13 EMD63648.1 - 0.0061 16.6 0.5 0.0079 16.2 0.5 1.3 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit OPT PF03169.15 EMD63649.1 - 0.0011 17.7 0.0 0.0013 17.4 0.0 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein DA1-like PF12315.8 EMD63649.1 - 0.13 11.7 0.1 0.14 11.5 0.1 1.1 1 0 0 1 1 1 0 Protein DA1 HAD_2 PF13419.6 EMD63650.1 - 0.0019 18.3 0.1 0.0033 17.5 0.1 1.4 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase DUF1990 PF09348.10 EMD63650.1 - 0.18 11.8 0.2 11 6.1 0.0 2.9 3 1 0 3 3 3 0 Domain of unknown function (DUF1990) Sugar_tr PF00083.24 EMD63651.1 - 2.5e-99 333.2 18.6 3e-99 332.9 18.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD63651.1 - 6.5e-19 68.1 33.8 1.2e-15 57.3 8.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TFIIA PF03153.13 EMD63652.1 - 4.8 7.1 21.3 5.7 6.8 21.3 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CFEM PF05730.11 EMD63653.1 - 0.00017 21.6 3.8 0.00024 21.1 3.8 1.2 1 0 0 1 1 1 1 CFEM domain RRM_1 PF00076.22 EMD63655.1 - 5e-10 39.0 0.0 6.9e-10 38.6 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EMD63655.1 - 0.00087 19.2 0.0 0.0012 18.7 0.0 1.2 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif FAD_binding_4 PF01565.23 EMD63656.1 - 7.7e-26 90.5 0.2 1.6e-25 89.5 0.2 1.6 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EMD63656.1 - 0.044 13.9 1.0 0.061 13.4 0.1 1.8 2 0 0 2 2 2 0 Berberine and berberine like DHHA1 PF02272.19 EMD63656.1 - 0.18 12.2 0.1 0.48 10.8 0.1 1.7 1 0 0 1 1 1 0 DHHA1 domain DUF2561 PF10812.8 EMD63657.1 - 0.0096 16.0 0.0 0.02 14.9 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2561) zf-CCCH_2 PF14608.6 EMD63658.1 - 1.8e-09 37.7 49.6 0.0046 17.4 4.4 5.4 5 0 0 5 5 5 4 RNA-binding, Nab2-type zinc finger Forkhead_N PF08430.12 EMD63658.1 - 8.3 7.0 31.8 10 6.8 22.3 2.6 2 0 0 2 2 2 0 Forkhead N-terminal region Amino_oxidase PF01593.24 EMD63659.1 - 3.6e-23 82.6 0.1 4.3e-22 79.0 0.1 2.0 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EMD63659.1 - 9.2e-12 45.0 0.5 3.5e-11 43.2 0.2 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EMD63659.1 - 1.9e-08 34.3 0.0 2.5e-05 24.0 0.0 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase Thi4 PF01946.17 EMD63659.1 - 0.011 15.0 0.0 0.018 14.3 0.0 1.3 1 0 0 1 1 1 0 Thi4 family Pyr_redox_2 PF07992.14 EMD63659.1 - 0.025 13.8 0.1 0.15 11.2 0.0 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase MCRA PF06100.11 EMD63659.1 - 0.11 11.3 0.0 0.18 10.6 0.0 1.2 1 0 0 1 1 1 0 MCRA family Pyr_redox PF00070.27 EMD63659.1 - 0.11 13.0 0.1 2.3 8.8 0.0 2.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pkinase PF00069.25 EMD63661.1 - 2.5e-47 161.4 0.0 3.5e-47 161.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD63661.1 - 3.7e-27 95.2 0.0 4.8e-26 91.6 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMD63661.1 - 0.0099 15.2 0.0 0.018 14.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EMD63661.1 - 0.11 11.2 0.0 0.26 10.0 0.0 1.5 2 0 0 2 2 2 0 Fungal protein kinase Spermine_synth PF01564.17 EMD63663.1 - 9.7e-06 25.1 0.0 1.8e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 Spermine/spermidine synthase domain DUF2052 PF09747.9 EMD63664.1 - 8.5e-24 84.8 18.1 2.8e-12 47.2 1.0 2.8 2 1 1 3 3 3 2 Coiled-coil domain containing protein (DUF2052) AA_permease PF00324.21 EMD63666.1 - 1.3e-122 409.9 42.1 1.6e-122 409.5 42.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EMD63666.1 - 1.5e-34 119.6 43.6 1.8e-34 119.3 43.6 1.1 1 0 0 1 1 1 1 Amino acid permease Prion_bPrPp PF11587.8 EMD63666.1 - 3.7 7.5 4.7 2.1 8.3 0.2 2.6 2 0 0 2 2 2 0 Major prion protein bPrPp - N terminal CNH PF00780.22 EMD63667.1 - 1.3e-76 257.8 0.0 1.9e-76 257.3 0.0 1.2 1 0 0 1 1 1 1 CNH domain RhoGEF PF00621.20 EMD63667.1 - 2.7e-31 109.2 0.0 4.3e-31 108.6 0.0 1.3 1 0 0 1 1 1 1 RhoGEF domain PH_5 PF15405.6 EMD63667.1 - 3.5e-12 46.6 0.0 3.5e-11 43.4 0.0 2.3 1 1 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 EMD63667.1 - 0.0062 17.0 0.0 0.046 14.2 0.0 2.4 3 0 0 3 3 3 1 PH domain Gly_transf_sug PF04488.15 EMD63668.1 - 7.1e-14 52.2 0.3 2.1e-13 50.7 0.2 1.9 2 0 0 2 2 2 1 Glycosyltransferase sugar-binding region containing DXD motif Caps_synth PF05704.12 EMD63668.1 - 0.0025 17.2 0.2 0.0047 16.3 0.2 1.4 1 1 0 1 1 1 1 Capsular polysaccharide synthesis protein Acyl_transf_3 PF01757.22 EMD63669.1 - 6.9e-29 101.0 34.5 8.5e-29 100.7 34.5 1.1 1 0 0 1 1 1 1 Acyltransferase family Hydantoinase_B PF02538.14 EMD63670.1 - 9.3e-218 723.8 0.0 1.4e-217 723.2 0.0 1.3 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Hydantoinase_A PF01968.18 EMD63670.1 - 1.1e-102 343.3 0.1 2.5e-102 342.1 0.1 1.7 1 0 0 1 1 1 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.13 EMD63670.1 - 1.7e-62 210.3 1.4 4.2e-61 205.8 0.0 2.6 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase N-terminal region PapG_C PF03628.13 EMD63671.1 - 0.014 15.3 0.0 0.25 11.3 0.0 2.2 2 0 0 2 2 2 0 PapG chaperone-binding domain Fungal_trans PF04082.18 EMD63671.1 - 0.023 13.8 0.0 0.052 12.6 0.0 1.6 1 0 0 1 1 1 0 Fungal specific transcription factor domain PEP_hydrolase PF09370.10 EMD63672.1 - 1.4e-136 453.9 1.0 1.6e-136 453.8 1.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate hydrolase-like NMO PF03060.15 EMD63672.1 - 2.2e-05 24.0 0.2 3.4e-05 23.4 0.2 1.2 1 0 0 1 1 1 1 Nitronate monooxygenase UPF0261 PF06792.11 EMD63673.1 - 4.1e-172 572.7 2.1 4.6e-172 572.5 2.1 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0261) Glyco_hydro_76 PF03663.14 EMD63674.1 - 2.9e-106 356.1 9.7 3.7e-106 355.7 9.7 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_47 PF01532.20 EMD63674.1 - 0.017 14.0 0.0 2.5 6.9 0.0 2.3 2 0 0 2 2 2 0 Glycosyl hydrolase family 47 FAD_binding_6 PF00970.24 EMD63675.1 - 1.1e-31 109.1 0.0 1.7e-31 108.5 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 EMD63675.1 - 1.4e-28 99.7 0.0 2.4e-28 99.0 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 EMD63675.1 - 3.2e-05 24.1 0.0 0.0068 16.5 0.0 2.2 2 0 0 2 2 2 2 Ferric reductase NAD binding domain FAD_binding_9 PF08021.11 EMD63675.1 - 0.0011 19.2 0.0 0.002 18.4 0.0 1.4 1 0 0 1 1 1 1 Siderophore-interacting FAD-binding domain TPR_10 PF13374.6 EMD63676.1 - 7.3e-09 35.2 0.3 1.1e-08 34.7 0.2 1.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 EMD63676.1 - 1.7e-06 28.2 0.1 1.9e-06 28.0 0.1 1.0 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_10 PF13374.6 EMD63677.1 - 1.5e-86 282.2 14.9 3.5e-13 48.9 0.0 8.4 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_12 PF13424.6 EMD63677.1 - 5.1e-76 251.0 18.8 8.3e-16 58.0 0.1 7.1 1 1 6 7 7 7 7 Tetratricopeptide repeat TPR_7 PF13176.6 EMD63677.1 - 3.4e-30 101.8 6.7 0.0036 17.2 0.0 7.2 7 0 0 7 7 6 6 Tetratricopeptide repeat TPR_19 PF14559.6 EMD63677.1 - 2.7e-16 59.8 2.0 0.88 10.1 0.0 7.9 2 1 6 8 8 7 4 Tetratricopeptide repeat TPR_17 PF13431.6 EMD63677.1 - 8e-16 57.2 4.8 0.45 11.0 0.0 7.9 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_4 PF07721.14 EMD63677.1 - 2.5e-15 55.5 0.2 1.3 9.9 0.0 7.3 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_MalT PF17874.1 EMD63677.1 - 9.2e-15 54.8 15.4 3.1e-08 33.4 1.6 3.1 2 1 2 4 4 4 3 MalT-like TPR region TPR_16 PF13432.6 EMD63677.1 - 3.3e-14 53.2 1.9 0.72 10.6 0.0 7.8 6 2 2 8 8 7 2 Tetratricopeptide repeat TPR_2 PF07719.17 EMD63677.1 - 3.3e-14 51.8 15.0 2.2 8.6 0.0 8.6 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_1 PF00515.28 EMD63677.1 - 6.5e-14 51.1 9.9 1.7 8.6 0.0 7.7 8 0 0 8 8 8 6 Tetratricopeptide repeat NB-ARC PF00931.22 EMD63677.1 - 1.7e-12 47.1 0.5 5.9e-12 45.3 0.0 2.2 2 1 0 3 3 3 1 NB-ARC domain HET PF06985.11 EMD63677.1 - 9.6e-12 45.5 11.4 2.1e-08 34.6 6.0 4.0 2 1 1 3 3 3 2 Heterokaryon incompatibility protein (HET) TPR_8 PF13181.6 EMD63677.1 - 5.5e-08 32.4 11.8 8.2 6.9 0.1 7.5 8 0 0 8 8 6 0 Tetratricopeptide repeat AAA_16 PF13191.6 EMD63677.1 - 2.7e-05 24.6 3.2 6.4e-05 23.4 0.3 2.9 2 1 0 2 2 2 1 AAA ATPase domain TPR_14 PF13428.6 EMD63677.1 - 0.0014 19.3 17.9 42 5.3 0.0 8.0 9 0 0 9 9 6 0 Tetratricopeptide repeat AAA_22 PF13401.6 EMD63677.1 - 0.0018 18.6 0.1 0.0086 16.4 0.0 2.3 2 1 0 2 2 1 1 AAA domain CutA1 PF03091.15 EMD63677.1 - 0.0035 17.2 20.2 29 4.6 0.1 7.5 3 2 1 7 7 7 0 CutA1 divalent ion tolerance protein NACHT PF05729.12 EMD63677.1 - 0.0083 16.1 0.0 0.028 14.3 0.0 2.0 1 1 0 1 1 1 1 NACHT domain ATPase_2 PF01637.18 EMD63677.1 - 0.021 14.7 0.0 0.046 13.6 0.0 1.5 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea DUF1897 PF09005.10 EMD63677.1 - 0.028 13.9 7.2 22 4.7 0.1 4.9 6 0 0 6 6 6 0 Domain of unknown function (DUF1897) BRX_assoc PF16627.5 EMD63677.1 - 0.077 13.1 1.5 2.5e+02 1.9 0.0 4.7 4 0 0 4 4 4 0 Unstructured region between BRX_N and BRX domain IstB_IS21 PF01695.17 EMD63677.1 - 0.083 12.6 0.0 0.21 11.3 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein TPR_6 PF13174.6 EMD63677.1 - 0.14 12.9 10.6 3e+02 2.4 0.1 7.5 6 0 0 6 6 6 0 Tetratricopeptide repeat RPN6_N PF18055.1 EMD63677.1 - 0.18 12.2 4.0 21 5.5 0.1 3.7 3 1 0 3 3 3 0 26S proteasome regulatory subunit RPN6 N-terminal domain zf-Mss51 PF13824.6 EMD63677.1 - 1 9.5 4.2 1.3e+02 2.7 0.0 4.7 6 0 0 6 6 4 0 Zinc-finger of mitochondrial splicing suppressor 51 Osmo_CC PF08946.10 EMD63677.1 - 6.5 7.1 9.5 1.7e+02 2.5 0.1 5.4 5 0 0 5 5 4 0 Osmosensory transporter coiled coil TPR_2 PF07719.17 EMD63678.1 - 4.5e-36 120.1 26.0 3.6e-07 29.8 1.3 10.5 12 0 0 12 12 11 7 Tetratricopeptide repeat TPR_1 PF00515.28 EMD63678.1 - 3.1e-35 118.6 18.9 1.4e-06 27.9 1.7 9.3 10 0 0 10 10 10 6 Tetratricopeptide repeat ANAPC3 PF12895.7 EMD63678.1 - 1.8e-33 114.6 12.0 1e-19 70.6 0.3 6.0 4 1 3 7 7 7 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 EMD63678.1 - 2.1e-30 102.4 17.2 2.8e-05 24.0 0.3 10.8 11 0 0 11 11 11 6 Tetratricopeptide repeat TPR_16 PF13432.6 EMD63678.1 - 1.3e-22 80.2 28.2 5.4e-08 33.4 1.9 7.8 6 3 4 10 10 9 4 Tetratricopeptide repeat TPR_12 PF13424.6 EMD63678.1 - 1.9e-21 76.1 21.5 1.6e-07 31.5 0.1 8.4 5 3 2 7 7 7 4 Tetratricopeptide repeat TPR_19 PF14559.6 EMD63678.1 - 8.2e-21 74.3 13.1 0.00013 22.4 0.2 8.2 7 1 1 8 8 8 4 Tetratricopeptide repeat TPR_11 PF13414.6 EMD63678.1 - 9.8e-21 73.2 19.1 9.2e-06 25.2 0.7 9.4 6 2 4 10 10 10 5 TPR repeat TPR_14 PF13428.6 EMD63678.1 - 5.3e-19 67.3 18.7 0.0049 17.6 0.0 10.3 7 2 4 11 11 10 6 Tetratricopeptide repeat TPR_17 PF13431.6 EMD63678.1 - 1.7e-18 65.6 12.6 0.099 13.1 0.0 8.8 9 0 0 9 9 8 5 Tetratricopeptide repeat TPR_7 PF13176.6 EMD63678.1 - 9.3e-13 47.2 12.4 0.025 14.6 0.2 7.2 8 0 0 8 8 7 4 Tetratricopeptide repeat TPR_6 PF13174.6 EMD63678.1 - 1.4e-10 41.1 18.4 0.59 10.9 0.0 10.4 12 0 0 12 12 10 2 Tetratricopeptide repeat TPR_9 PF13371.6 EMD63678.1 - 9.9e-08 32.0 10.9 0.026 14.6 0.1 6.1 4 1 2 7 7 7 3 Tetratricopeptide repeat TPR_20 PF14561.6 EMD63678.1 - 3e-05 24.3 0.7 3.2 8.1 0.2 4.8 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_15 PF13429.6 EMD63678.1 - 6.2e-05 22.4 8.7 0.0069 15.6 4.7 3.3 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.6 EMD63678.1 - 0.001 18.9 13.9 0.28 11.1 0.3 6.6 8 0 0 8 8 7 1 Tetratricopeptide repeat FAT PF02259.23 EMD63678.1 - 0.038 13.2 2.0 0.96 8.6 1.7 2.7 2 1 0 2 2 2 0 FAT domain TOM20_plant PF06552.12 EMD63678.1 - 0.072 12.8 1.5 0.85 9.3 0.4 2.7 2 1 0 2 2 2 0 Plant specific mitochondrial import receptor subunit TOM20 DUF4810 PF16068.5 EMD63678.1 - 0.11 13.1 2.4 39 4.9 0.0 3.9 4 0 0 4 4 4 0 Domain of unknown function (DUF4810) RPN7 PF10602.9 EMD63678.1 - 0.16 11.7 3.4 24 4.6 0.0 3.6 3 0 0 3 3 3 0 26S proteasome subunit RPN7 TPR_21 PF09976.9 EMD63678.1 - 1.7 8.3 8.8 3.3 7.4 0.2 4.0 3 1 1 4 4 4 0 Tetratricopeptide repeat-like domain DUF5113 PF17140.4 EMD63678.1 - 2.8 7.7 7.3 2.6 7.8 2.1 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF5113) BTAD PF03704.17 EMD63678.1 - 9 6.7 10.3 62 4.0 0.3 4.4 3 1 2 5 5 5 0 Bacterial transcriptional activator domain TMEM208_SND2 PF05620.11 EMD63679.1 - 6.9e-55 185.4 0.6 7.8e-55 185.2 0.6 1.0 1 0 0 1 1 1 1 SRP-independent targeting protein 2/TMEM208 Bot1p PF12298.8 EMD63680.1 - 6.2e-55 186.0 2.2 6.2e-55 186.0 2.2 2.7 3 0 0 3 3 3 1 Eukaryotic mitochondrial regulator protein DUF3987 PF13148.6 EMD63680.1 - 2.7 6.9 10.2 0.22 10.5 1.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3987) RRM_1 PF00076.22 EMD63682.1 - 1.2e-16 60.2 0.0 6.8e-14 51.4 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EMD63682.1 - 0.052 13.4 0.0 0.09 12.6 0.0 1.3 1 0 0 1 1 1 0 Occluded RNA-recognition motif Sugar_tr PF00083.24 EMD63684.1 - 1.3e-11 44.1 1.9 1.4e-11 43.9 1.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter Nitroreductase PF00881.24 EMD63685.1 - 9.7e-14 51.8 0.0 1.3e-13 51.4 0.0 1.1 1 0 0 1 1 1 1 Nitroreductase family zf-C3H1 PF10650.9 EMD63687.1 - 1.1e-11 44.2 3.2 1.7e-11 43.6 3.2 1.3 1 0 0 1 1 1 1 Putative zinc-finger domain YabA PF06156.13 EMD63687.1 - 2.4 8.8 7.0 1.7 9.3 2.9 2.6 2 0 0 2 2 2 0 Initiation control protein YabA V_ATPase_I PF01496.19 EMD63687.1 - 2.9 5.7 3.8 6.5 4.5 3.8 1.6 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Bacillus_HBL PF05791.11 EMD63687.1 - 3.4 7.5 6.8 0.23 11.2 1.2 1.8 2 0 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) Sod_Cu PF00080.20 EMD63688.1 - 6.9e-47 159.2 7.4 7.9e-47 159.0 7.4 1.0 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) TAL_FSA PF00923.19 EMD63689.1 - 2e-94 316.2 2.6 2.2e-94 316.0 2.6 1.0 1 0 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase C5-epim_C PF06662.13 EMD63689.1 - 0.0041 16.6 0.0 0.0072 15.9 0.0 1.3 1 0 0 1 1 1 1 D-glucuronyl C5-epimerase C-terminus adh_short PF00106.25 EMD63690.1 - 3.3e-34 118.1 0.0 5e-34 117.5 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD63690.1 - 3.9e-24 85.5 0.0 2.1e-23 83.1 0.0 1.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD63690.1 - 0.0031 17.4 0.0 0.34 10.8 0.0 2.1 2 0 0 2 2 2 2 KR domain NMT1_2 PF13379.6 EMD63690.1 - 0.11 12.2 0.1 0.18 11.4 0.1 1.4 1 1 0 1 1 1 0 NMT1-like family Acyltransferase PF01553.21 EMD63691.1 - 9.8e-33 112.6 0.0 1.5e-32 112.1 0.0 1.2 1 0 0 1 1 1 1 Acyltransferase Voltage_CLC PF00654.20 EMD63692.1 - 0.0011 18.3 2.3 0.0013 18.0 2.3 1.2 1 0 0 1 1 1 1 Voltage gated chloride channel 7tm_3 PF00003.22 EMD63692.1 - 0.004 16.9 0.7 0.004 16.9 0.7 1.9 2 0 0 2 2 2 1 7 transmembrane sweet-taste receptor of 3 GCPR DUF2116 PF09889.9 EMD63692.1 - 0.12 12.4 1.3 3.4 7.7 0.2 2.3 2 0 0 2 2 2 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) Tetraspanin PF00335.20 EMD63692.1 - 0.27 10.9 4.9 0.08 12.6 1.7 1.9 1 1 1 2 2 2 0 Tetraspanin family DUF4234 PF14018.6 EMD63692.1 - 0.89 9.7 4.1 7.5 6.8 4.1 2.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4234) CcmD PF04995.14 EMD63692.1 - 3.2 7.9 6.0 2.1 8.5 0.4 3.3 2 1 1 3 3 3 0 Heme exporter protein D (CcmD) DUF202 PF02656.15 EMD63692.1 - 4.6 7.8 14.1 14 6.2 2.3 3.3 2 1 0 2 2 2 0 Domain of unknown function (DUF202) DUF2207 PF09972.9 EMD63692.1 - 8.6 5.0 6.8 20 3.8 6.8 1.7 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) MARVEL PF01284.23 EMD63692.1 - 9 6.3 12.5 26 4.8 9.0 2.7 2 1 0 2 2 2 0 Membrane-associating domain Glyco_hydro_16 PF00722.21 EMD63694.1 - 2.6e-38 131.2 1.2 4.1e-38 130.6 1.2 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 RIO1 PF01163.22 EMD63695.1 - 1.3e-67 227.1 0.4 2.5e-67 226.1 0.4 1.5 1 0 0 1 1 1 1 RIO1 family Pkinase_fungal PF17667.1 EMD63695.1 - 0.011 14.5 0.1 0.011 14.5 0.1 1.8 2 0 0 2 2 2 0 Fungal protein kinase NAD_binding_10 PF13460.6 EMD63696.1 - 1.7e-07 31.4 0.0 1.3e-06 28.5 0.0 2.3 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EMD63696.1 - 4.8e-07 29.5 0.0 1.8e-06 27.6 0.0 1.9 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EMD63696.1 - 3.5e-06 26.3 0.0 4.5e-05 22.6 0.0 2.0 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 EMD63696.1 - 0.0082 15.6 0.0 0.013 14.9 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 EMD63696.1 - 0.014 14.5 0.0 0.043 12.9 0.0 1.7 2 0 0 2 2 2 0 RmlD substrate binding domain NAD_binding_4 PF07993.12 EMD63696.1 - 0.25 10.5 0.6 5.3 6.1 0.0 2.9 3 1 1 4 4 4 0 Male sterility protein DUF5446 PF17522.2 EMD63697.1 - 0.093 12.9 2.1 0.38 11.0 1.1 2.0 1 1 1 2 2 2 0 Family of unknown function (DUF5446) FPN1 PF06963.12 EMD63697.1 - 0.17 10.4 0.0 0.19 10.2 0.0 1.0 1 0 0 1 1 1 0 Ferroportin1 (FPN1) Vps54 PF07928.12 EMD63697.1 - 0.17 12.3 0.0 0.24 11.8 0.0 1.2 1 0 0 1 1 1 0 Vps54-like protein WD40 PF00400.32 EMD63698.1 - 6.4e-31 105.9 9.7 2.1e-08 34.7 0.1 5.1 5 0 0 5 5 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD63698.1 - 3.2e-11 43.4 0.1 0.0064 16.8 0.0 3.8 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain AAA_16 PF13191.6 EMD63698.1 - 6.9e-08 33.1 2.1 1.4e-07 32.0 0.9 2.2 2 0 0 2 2 1 1 AAA ATPase domain NACHT PF05729.12 EMD63698.1 - 9.6e-08 32.1 0.0 2.2e-07 30.9 0.0 1.5 1 0 0 1 1 1 1 NACHT domain Ge1_WD40 PF16529.5 EMD63698.1 - 9.8e-08 31.3 0.3 0.25 10.3 0.0 3.3 1 1 2 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Proteasome_A_N PF10584.9 EMD63698.1 - 1.5e-07 30.9 0.1 4.3 7.1 0.0 4.7 5 0 0 5 5 5 2 Proteasome subunit A N-terminal signature eIF2A PF08662.11 EMD63698.1 - 6.2e-05 23.0 0.0 0.4 10.5 0.0 2.2 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 EMD63698.1 - 0.0004 19.2 0.2 1.6 7.3 0.0 3.1 2 1 1 3 3 3 2 Nucleoporin Nup120/160 PD40 PF07676.12 EMD63698.1 - 0.00088 19.2 0.0 7.1 6.7 0.0 4.2 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat APS_kinase PF01583.20 EMD63698.1 - 0.0025 17.7 0.1 0.0068 16.3 0.0 1.8 2 0 0 2 2 1 1 Adenylylsulphate kinase KAP_NTPase PF07693.14 EMD63698.1 - 0.023 13.9 0.0 0.039 13.2 0.0 1.3 1 0 0 1 1 1 0 KAP family P-loop domain SMP_2 PF10144.9 EMD63698.1 - 0.044 13.4 0.0 21 4.8 0.0 3.1 1 1 1 3 3 3 0 Bacterial virulence factor haemolysin DUF4265 PF14085.6 EMD63698.1 - 0.052 13.5 0.6 21 5.1 0.0 3.3 2 1 1 3 3 3 0 Domain of unknown function (DUF4265) AAA_22 PF13401.6 EMD63698.1 - 0.055 13.7 0.0 0.15 12.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 EMD63698.1 - 0.074 13.5 0.0 0.23 11.9 0.0 1.9 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Stimulus_sens_1 PF13756.6 EMD63698.1 - 0.097 13.3 0.0 20 5.8 0.0 3.3 3 0 0 3 3 3 0 Stimulus-sensing domain AAA_18 PF13238.6 EMD63698.1 - 0.1 13.2 0.2 0.48 11.0 0.1 2.2 2 1 0 2 2 2 0 AAA domain AAA_33 PF13671.6 EMD63698.1 - 0.11 12.6 0.2 0.99 9.6 0.0 2.6 3 0 0 3 3 3 0 AAA domain AAA_30 PF13604.6 EMD63698.1 - 0.12 12.1 0.0 0.27 10.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain IKI3 PF04762.12 EMD63698.1 - 0.15 10.1 0.1 0.52 8.2 0.0 1.7 1 1 0 1 1 1 0 IKI3 family NB-ARC PF00931.22 EMD63698.1 - 0.19 10.9 0.0 0.33 10.1 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain p450 PF00067.22 EMD63699.1 - 1.2e-17 63.8 0.0 4.6e-17 61.9 0.0 1.7 1 1 0 1 1 1 1 Cytochrome P450 HAUS4 PF14735.6 EMD63699.1 - 0.087 12.5 0.0 14 5.3 0.0 2.5 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 4 AMP-binding PF00501.28 EMD63700.1 - 0 1029.3 0.0 8.9e-79 265.0 0.0 4.3 4 0 0 4 4 4 4 AMP-binding enzyme Condensation PF00668.20 EMD63700.1 - 1.3e-244 812.0 0.0 1.1e-82 278.1 0.1 4.5 4 0 0 4 4 4 4 Condensation domain PP-binding PF00550.25 EMD63700.1 - 3.9e-56 187.3 8.7 4.5e-13 49.3 0.1 4.8 4 0 0 4 4 4 4 Phosphopantetheine attachment site AMP-binding_C PF13193.6 EMD63700.1 - 6.5e-21 75.1 7.3 0.00016 22.5 0.0 6.8 6 0 0 6 6 6 4 AMP-binding enzyme C-terminal domain Methyltransf_25 PF13649.6 EMD63700.1 - 4.5e-13 49.7 0.0 1.2e-05 25.9 0.0 3.6 3 0 0 3 3 3 2 Methyltransferase domain Methyltransf_23 PF13489.6 EMD63700.1 - 4.4e-12 46.1 0.0 0.00051 19.9 0.0 3.7 3 0 0 3 3 3 2 Methyltransferase domain Methyltransf_12 PF08242.12 EMD63700.1 - 3.9e-11 43.6 0.0 0.00017 22.3 0.0 3.0 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_11 PF08241.12 EMD63700.1 - 1.1e-10 42.1 0.0 0.00012 22.6 0.0 3.3 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_31 PF13847.6 EMD63700.1 - 3.6e-08 33.4 0.0 0.0018 18.1 0.0 2.9 2 0 0 2 2 2 2 Methyltransferase domain DUF547 PF04784.14 EMD63700.1 - 6.8e-05 22.9 0.0 0.014 15.4 0.0 3.5 3 0 0 3 3 3 1 Protein of unknown function, DUF547 NodS PF05401.11 EMD63700.1 - 0.006 16.2 0.0 0.018 14.7 0.0 1.7 1 0 0 1 1 1 1 Nodulation protein S (NodS) Methyltransf_16 PF10294.9 EMD63700.1 - 0.019 14.7 0.0 1.8 8.3 0.0 2.5 2 0 0 2 2 2 0 Lysine methyltransferase ASC PF00858.24 EMD63700.1 - 0.03 13.3 0.0 5.5 5.8 0.0 2.2 2 0 0 2 2 2 0 Amiloride-sensitive sodium channel YEATS PF03366.16 EMD63701.1 - 3.9e-27 94.0 0.1 7.7e-27 93.1 0.1 1.5 1 0 0 1 1 1 1 YEATS family Med21 PF11221.8 EMD63701.1 - 0.081 13.2 3.1 0.15 12.3 3.1 1.5 1 0 0 1 1 1 0 Subunit 21 of Mediator complex Ribosomal_L29 PF00831.23 EMD63701.1 - 0.41 10.6 4.6 0.17 11.9 0.7 2.2 1 1 1 2 2 2 0 Ribosomal L29 protein GST_C PF00043.25 EMD63702.1 - 2.4e-15 56.5 0.3 1.3e-14 54.1 0.0 2.1 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EMD63702.1 - 5e-11 42.7 0.1 1.3e-10 41.3 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EMD63702.1 - 1.5e-09 37.8 0.0 3e-09 36.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EMD63702.1 - 3.9e-08 33.5 0.0 8e-08 32.5 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EMD63702.1 - 4.4e-07 30.2 0.0 8.2e-07 29.4 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EMD63702.1 - 1.2e-06 28.7 0.0 2.1e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Mistic PF11458.8 EMD63702.1 - 0.078 12.9 1.4 0.77 9.8 0.4 2.3 2 0 0 2 2 2 0 Membrane-integrating protein Mistic MARVEL PF01284.23 EMD63703.1 - 1.8e-06 28.1 9.2 2.9e-06 27.4 9.2 1.3 1 0 0 1 1 1 1 Membrane-associating domain EpsG PF14897.6 EMD63703.1 - 0.0038 16.6 1.6 0.0038 16.6 1.6 1.4 1 1 0 1 1 1 1 EpsG family PBP_N PF17093.5 EMD63703.1 - 0.24 11.7 1.1 4.2 7.6 0.0 2.1 2 0 0 2 2 2 0 Penicillin-binding protein N-terminus DUF2207 PF09972.9 EMD63703.1 - 3.5 6.3 8.8 15 4.2 9.1 1.8 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) FA_desaturase PF00487.24 EMD63703.1 - 4.7 7.0 13.1 26 4.5 13.1 1.9 1 1 0 1 1 1 0 Fatty acid desaturase Ras PF00071.22 EMD63704.1 - 3.8e-41 140.4 0.0 6e-41 139.7 0.0 1.3 1 0 0 1 1 1 1 Ras family Grg1 PF11034.8 EMD63704.1 - 3.1e-25 88.2 9.6 5.3e-25 87.4 9.6 1.4 1 0 0 1 1 1 1 Glucose-repressible protein Grg1 Roc PF08477.13 EMD63704.1 - 4.2e-08 33.4 0.0 8.9e-08 32.4 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 EMD63704.1 - 0.014 14.9 0.0 0.029 13.9 0.0 1.5 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain Arf PF00025.21 EMD63704.1 - 0.017 14.6 0.0 0.028 13.9 0.0 1.4 1 0 0 1 1 1 0 ADP-ribosylation factor family DUF4491 PF14898.6 EMD63704.1 - 0.048 14.1 0.0 0.088 13.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4491) EMC1_C PF07774.13 EMD63706.1 - 8.9e-74 247.7 0.0 2.3e-73 246.4 0.0 1.7 2 0 0 2 2 2 1 ER membrane protein complex subunit 1, C-terminal PQQ_2 PF13360.6 EMD63706.1 - 2.1e-29 102.8 8.8 2.4e-26 92.8 0.8 4.0 3 1 1 4 4 4 2 PQQ-like domain PQQ PF01011.21 EMD63706.1 - 3.8e-09 36.0 3.1 0.16 12.0 0.1 5.4 5 0 0 5 5 5 2 PQQ enzyme repeat PQQ_3 PF13570.6 EMD63706.1 - 0.089 13.3 6.8 13 6.4 0.0 6.1 8 1 1 9 9 9 0 PQQ-like domain MHC_II_alpha PF00993.20 EMD63706.1 - 0.2 11.4 0.0 0.55 9.9 0.0 1.7 1 0 0 1 1 1 0 Class II histocompatibility antigen, alpha domain p450 PF00067.22 EMD63707.1 - 2.7e-51 174.8 0.0 4.9e-51 173.9 0.0 1.3 1 1 0 1 1 1 1 Cytochrome P450 Methyltransf_23 PF13489.6 EMD63708.1 - 3.3e-23 82.3 0.0 4.5e-23 81.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMD63708.1 - 2.1e-11 44.4 0.0 6.1e-11 42.9 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMD63708.1 - 3.1e-08 34.3 0.0 1.5e-07 32.0 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMD63708.1 - 4.2e-08 33.7 0.0 7.8e-08 32.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMD63708.1 - 2.7e-07 30.5 0.0 0.0071 16.2 0.0 2.1 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_16 PF10294.9 EMD63708.1 - 0.013 15.2 0.0 0.021 14.6 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase DUF938 PF06080.12 EMD63708.1 - 0.02 14.7 0.0 0.1 12.4 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF938) PrmA PF06325.13 EMD63708.1 - 0.041 13.3 0.0 0.052 12.9 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 EMD63708.1 - 0.088 12.4 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Ubie_methyltran PF01209.18 EMD63708.1 - 0.094 12.0 0.0 0.54 9.6 0.0 2.0 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family APG17 PF04108.12 EMD63709.1 - 7.9e-113 377.5 3.5 9e-113 377.4 3.5 1.0 1 0 0 1 1 1 1 Autophagy protein Apg17 Baculo_PEP_C PF04513.12 EMD63709.1 - 0.00052 20.1 7.8 2.1 8.4 0.8 3.5 2 1 0 3 3 3 3 Baculovirus polyhedron envelope protein, PEP, C terminus Bacillus_HBL PF05791.11 EMD63709.1 - 0.0039 17.0 0.8 0.037 13.8 0.0 2.6 2 1 1 3 3 3 1 Bacillus haemolytic enterotoxin (HBL) TelA PF05816.11 EMD63709.1 - 0.034 13.2 4.5 3.6 6.6 0.0 4.0 4 1 0 5 5 5 0 Toxic anion resistance protein (TelA) YabA PF06156.13 EMD63709.1 - 0.036 14.7 5.9 2.3 8.9 0.0 3.7 4 0 0 4 4 3 0 Initiation control protein YabA DprA_WH PF17782.1 EMD63709.1 - 0.055 13.6 1.6 0.081 13.0 0.1 2.1 2 0 0 2 2 2 0 DprA winged helix domain BLOC1_2 PF10046.9 EMD63709.1 - 0.1 12.9 8.9 0.55 10.6 0.5 3.9 4 0 0 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 EzrA PF06160.12 EMD63709.1 - 0.15 10.2 11.2 0.091 10.9 0.8 3.2 3 1 0 3 3 3 0 Septation ring formation regulator, EzrA DUF948 PF06103.11 EMD63709.1 - 0.56 10.5 5.5 30 5.0 0.4 3.9 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF948) NPV_P10 PF05531.12 EMD63709.1 - 0.9 10.1 6.2 9.9 6.7 0.7 3.3 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein TMPIT PF07851.13 EMD63709.1 - 2.1 7.5 5.1 1.5 8.0 0.3 2.6 2 1 0 3 3 3 0 TMPIT-like protein MCPsignal PF00015.21 EMD63709.1 - 2.2 8.1 8.8 0.11 12.3 0.9 2.5 3 0 0 3 3 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain CREPT PF16566.5 EMD63709.1 - 4.8 7.3 10.3 22 5.2 0.7 3.9 4 0 0 4 4 4 0 Cell-cycle alteration and expression-elevated protein in tumour GAS PF13851.6 EMD63709.1 - 6.8 6.0 13.9 9.2 5.6 0.3 3.4 3 1 1 4 4 4 0 Growth-arrest specific micro-tubule binding DUF2205 PF10224.9 EMD63709.1 - 7.5 6.6 0.0 7.5 6.6 0.0 4.8 4 2 3 7 7 7 0 Short coiled-coil protein KxDL PF10241.9 EMD63709.1 - 7.5 6.9 9.8 20 5.5 0.2 3.5 4 0 0 4 4 4 0 Uncharacterized conserved protein DUF1664 PF07889.12 EMD63709.1 - 8.8 6.4 11.1 9.1 6.3 1.4 3.8 4 0 0 4 4 4 0 Protein of unknown function (DUF1664) WD40 PF00400.32 EMD63710.1 - 9.6e-42 140.2 21.0 1.1e-06 29.2 0.1 8.7 8 0 0 8 8 8 7 WD domain, G-beta repeat F-box-like PF12937.7 EMD63710.1 - 2.6e-12 46.4 0.1 5.3e-12 45.4 0.1 1.6 1 0 0 1 1 1 1 F-box-like ANAPC4_WD40 PF12894.7 EMD63710.1 - 1.2e-10 41.6 0.1 0.0093 16.2 0.0 6.0 2 2 3 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain F-box PF00646.33 EMD63710.1 - 6.6e-10 38.6 0.4 6.8e-09 35.4 0.1 2.5 1 1 1 2 2 2 1 F-box domain Nup160 PF11715.8 EMD63710.1 - 4.7e-07 28.8 3.3 0.24 10.0 0.1 4.5 4 1 1 5 5 5 3 Nucleoporin Nup120/160 BBS2_Mid PF14783.6 EMD63710.1 - 0.00016 21.7 0.0 2.4 8.2 0.0 3.9 4 1 1 5 5 5 2 Ciliary BBSome complex subunit 2, middle region F-box_4 PF15966.5 EMD63710.1 - 0.0041 17.0 0.0 0.012 15.5 0.0 1.8 1 0 0 1 1 1 1 F-box PALB2_WD40 PF16756.5 EMD63710.1 - 0.0088 15.0 5.6 1.8 7.4 0.2 3.5 2 1 1 3 3 3 2 Partner and localizer of BRCA2 WD40 domain WD40_like PF17005.5 EMD63710.1 - 0.0092 15.3 0.0 0.035 13.4 0.0 1.8 2 0 0 2 2 2 1 WD40-like domain Ins_P5_2-kin PF06090.12 EMD63711.1 - 1.5e-51 175.8 0.0 2.2e-51 175.2 0.0 1.3 1 0 0 1 1 1 1 Inositol-pentakisphosphate 2-kinase DUF952 PF06108.12 EMD63712.1 - 2.9e-21 75.3 0.0 3.8e-21 74.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF952) Fungal_trans PF04082.18 EMD63713.1 - 2.5e-06 26.7 1.8 5.5e-05 22.3 1.8 2.3 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD63713.1 - 4.6e-06 26.6 8.3 8.3e-06 25.8 8.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain L31 PF09784.9 EMD63714.1 - 2.9e-46 156.1 2.7 3.2e-46 155.9 2.7 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L31 DUF4763 PF15960.5 EMD63714.1 - 0.066 12.5 0.3 0.075 12.3 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4763) Apolipo_F PF15148.6 EMD63714.1 - 0.19 11.2 0.1 0.24 10.9 0.1 1.1 1 0 0 1 1 1 0 Apolipoprotein F Sedlin_N PF04628.13 EMD63715.1 - 8.5e-32 110.0 0.0 9.7e-32 109.8 0.0 1.0 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region CPSase_L_D2 PF02786.17 EMD63720.1 - 4.5e-73 245.2 0.0 6.6e-73 244.7 0.0 1.2 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 EMD63720.1 - 1.1e-36 125.7 0.0 2.4e-36 124.6 0.0 1.6 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 EMD63720.1 - 5.8e-36 122.9 0.0 2.6e-35 120.8 0.0 2.1 2 0 0 2 2 2 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 EMD63720.1 - 7.2e-16 57.8 0.9 2.1e-15 56.3 0.9 1.9 1 0 0 1 1 1 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.13 EMD63720.1 - 3.7e-10 39.7 0.0 7.1e-10 38.8 0.0 1.5 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 EMD63720.1 - 3.6e-09 36.4 0.0 7e-09 35.5 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain Biotin_lipoyl_2 PF13533.6 EMD63720.1 - 3.4e-06 26.8 0.0 0.00035 20.3 0.1 2.8 1 1 1 2 2 2 1 Biotin-lipoyl like ATP-grasp_3 PF02655.14 EMD63720.1 - 0.0002 21.4 0.0 0.0004 20.5 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain GARS_A PF01071.19 EMD63720.1 - 0.0023 17.7 0.0 0.0037 17.0 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain GCV_H PF01597.19 EMD63720.1 - 0.0076 16.1 0.2 0.016 15.1 0.2 1.5 1 0 0 1 1 1 1 Glycine cleavage H-protein ATPgrasp_ST PF14397.6 EMD63720.1 - 0.12 11.7 0.0 0.2 10.8 0.0 1.3 1 0 0 1 1 1 0 Sugar-transfer associated ATP-grasp Pacs-1 PF10254.9 EMD63721.1 - 0.16 10.9 1.9 0.26 10.2 1.9 1.3 1 0 0 1 1 1 0 PACS-1 cytosolic sorting protein Herpes_U47 PF05467.11 EMD63721.1 - 8.9 4.3 12.0 12 3.9 12.0 1.1 1 0 0 1 1 1 0 Herpesvirus glycoprotein U47 RINGv PF12906.7 EMD63722.1 - 4.2e-16 58.8 9.0 7.6e-16 58.0 9.0 1.4 1 0 0 1 1 1 1 RING-variant domain zf-RING_2 PF13639.6 EMD63722.1 - 0.017 15.4 8.7 0.03 14.7 8.7 1.4 1 0 0 1 1 1 0 Ring finger domain zf-ANAPC11 PF12861.7 EMD63722.1 - 0.049 13.7 2.7 0.11 12.6 2.7 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.6 EMD63722.1 - 8.6 6.3 5.9 16 5.4 5.9 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Baculo_gp41 PF04700.12 EMD63723.1 - 0.11 12.2 0.7 0.88 9.3 0.2 2.8 2 0 0 2 2 2 0 Structural glycoprotein p40/gp41 conserved region Rpn9_C PF18261.1 EMD63723.1 - 0.17 11.5 0.0 0.36 10.4 0.0 1.5 1 0 0 1 1 1 0 Rpn9 C-terminal helix PGF-CTERM PF18204.1 EMD63724.1 - 0.078 13.0 1.6 0.13 12.3 1.6 1.4 1 0 0 1 1 1 0 PGF-CTERM motif RR_TM4-6 PF06459.12 EMD63724.1 - 2 8.2 20.5 4.4 7.0 20.5 1.5 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Mitofilin PF09731.9 EMD63724.1 - 2.1 7.1 20.4 0.62 8.8 16.6 1.8 2 0 0 2 2 2 0 Mitochondrial inner membrane protein Borrelia_P83 PF05262.11 EMD63724.1 - 3 6.2 16.6 4 5.8 16.6 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein XRN_N PF03159.18 EMD63724.1 - 5.4 6.4 7.5 8.5 5.7 7.5 1.2 1 0 0 1 1 1 0 XRN 5'-3' exonuclease N-terminus DUF4407 PF14362.6 EMD63724.1 - 7.6 5.8 8.9 12 5.1 8.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) MFS_1 PF07690.16 EMD63725.1 - 9.4e-36 123.4 51.3 9.4e-36 123.4 51.3 2.5 2 1 0 2 2 2 1 Major Facilitator Superfamily MFS_1_like PF12832.7 EMD63725.1 - 1.4e-05 24.1 24.0 0.00055 18.9 9.9 2.3 2 1 0 2 2 2 2 MFS_1 like family LacY_symp PF01306.19 EMD63725.1 - 0.00068 18.5 0.0 0.0018 17.1 0.0 1.7 1 0 0 1 1 1 1 LacY proton/sugar symporter OATP PF03137.20 EMD63725.1 - 2.1 6.6 8.3 0.2 9.9 0.2 2.8 2 1 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family Peptidase_U4 PF03419.13 EMD63725.1 - 3.9 6.7 9.0 0.29 10.4 1.9 2.3 2 0 0 2 2 2 0 Sporulation factor SpoIIGA Peptidase_M14 PF00246.24 EMD63726.1 - 9.9e-81 271.7 0.2 1.3e-80 271.3 0.2 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase Propep_M14 PF02244.16 EMD63726.1 - 7.6e-08 32.6 0.0 1.5e-07 31.7 0.0 1.5 1 0 0 1 1 1 1 Carboxypeptidase activation peptide DUF2142 PF09913.9 EMD63727.1 - 0.0049 15.8 0.1 0.0066 15.4 0.1 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2142) Glyco_transf_20 PF00982.21 EMD63728.1 - 1.2e-201 670.5 0.0 1.4e-201 670.3 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 20 Glyco_trans_1_4 PF13692.6 EMD63728.1 - 0.0012 19.2 0.0 0.0033 17.8 0.0 1.8 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_5 PF08323.11 EMD63728.1 - 0.023 14.4 0.1 0.045 13.4 0.1 1.6 1 0 0 1 1 1 0 Starch synthase catalytic domain Glycos_transf_1 PF00534.20 EMD63728.1 - 0.14 11.7 0.3 2.5 7.6 0.0 2.6 2 1 0 2 2 2 0 Glycosyl transferases group 1 Not1 PF04054.15 EMD63729.1 - 0.29 10.0 0.0 0.41 9.5 0.0 1.1 1 0 0 1 1 1 0 CCR4-Not complex component, Not1 SDF PF00375.18 EMD63730.1 - 3e-87 293.2 40.3 3.9e-87 292.8 40.3 1.0 1 0 0 1 1 1 1 Sodium:dicarboxylate symporter family CAAD PF14159.6 EMD63730.1 - 0.0011 18.8 0.7 0.0011 18.8 0.7 3.1 3 1 0 3 3 3 1 CAAD domains of cyanobacterial aminoacyl-tRNA synthetase DJ-1_PfpI PF01965.24 EMD63731.1 - 1.2e-09 38.2 0.0 4.4e-09 36.3 0.0 1.8 1 1 0 1 1 1 1 DJ-1/PfpI family ThiJ_like PF17124.5 EMD63731.1 - 5.7e-07 29.4 0.0 6.6e-07 29.2 0.0 1.1 1 0 0 1 1 1 1 ThiJ/PfpI family-like Pkinase PF00069.25 EMD63732.1 - 2.4e-28 99.2 0.0 3.3e-28 98.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD63732.1 - 9.4e-14 51.3 0.0 2.3e-13 50.0 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Glyco_transf_34 PF05637.12 EMD63733.1 - 8.6e-05 22.4 0.4 0.019 14.7 0.4 2.2 2 0 0 2 2 2 2 galactosyl transferase GMA12/MNN10 family HAD PF12710.7 EMD63734.1 - 0.0018 18.7 0.0 0.014 15.8 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF4238 PF14022.6 EMD63735.1 - 1.8e-33 116.3 0.0 5.2e-22 78.6 0.0 2.2 1 1 1 2 2 2 2 Protein of unknown function (DUF4238) MR_MLE_C PF13378.6 EMD63736.1 - 6e-58 196.0 0.0 7.7e-58 195.6 0.0 1.1 1 0 0 1 1 1 1 Enolase C-terminal domain-like MR_MLE_N PF02746.16 EMD63736.1 - 5.8e-17 62.0 0.0 1.1e-16 61.0 0.0 1.5 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain DHDPS PF00701.22 EMD63737.1 - 1.8e-26 92.5 0.0 2.9e-26 91.8 0.0 1.3 1 1 0 1 1 1 1 Dihydrodipicolinate synthetase family Med26_C PF15693.5 EMD63737.1 - 0.13 12.4 0.0 0.52 10.5 0.0 1.8 2 0 0 2 2 2 0 Mediator complex subunit 26 C-terminal DUF818 PF05677.12 EMD63737.1 - 0.21 10.5 0.0 0.32 9.9 0.0 1.2 1 0 0 1 1 1 0 Chlamydia CHLPS protein (DUF818) MFS_1 PF07690.16 EMD63738.1 - 1.9e-31 109.3 37.4 1.9e-31 109.3 37.4 2.3 1 1 1 2 2 2 1 Major Facilitator Superfamily DUF4064 PF13273.6 EMD63738.1 - 0.12 12.7 0.3 0.12 12.7 0.3 4.3 7 0 0 7 7 7 0 Protein of unknown function (DUF4064) IMS PF00817.20 EMD63739.1 - 1.8e-40 138.4 0.0 4.2e-40 137.2 0.0 1.7 1 0 0 1 1 1 1 impB/mucB/samB family REV1_C PF16727.5 EMD63739.1 - 3.5e-24 85.0 0.3 6.6e-24 84.1 0.3 1.5 1 0 0 1 1 1 1 DNA repair protein REV1 C-terminal domain UBM PF14377.6 EMD63739.1 - 4.7e-15 54.5 13.3 1.1e-06 27.9 0.6 4.6 5 0 0 5 5 5 3 Ubiquitin binding region BRCT_2 PF16589.5 EMD63739.1 - 3.7e-11 43.3 0.0 1.3e-10 41.6 0.0 2.0 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain IMS_C PF11799.8 EMD63739.1 - 1.1e-10 42.3 0.0 2.5e-10 41.1 0.0 1.6 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain BRCT PF00533.26 EMD63739.1 - 3.2e-07 30.6 0.0 8e-07 29.4 0.0 1.7 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 EMD63739.1 - 8.7e-06 25.6 0.0 1.9e-05 24.5 0.0 1.6 1 0 0 1 1 1 1 twin BRCT domain mCpol PF18182.1 EMD63739.1 - 0.00051 20.4 0.0 0.0017 18.6 0.0 1.9 1 0 0 1 1 1 1 minimal CRISPR polymerase domain LIG3_BRCT PF16759.5 EMD63739.1 - 0.011 16.1 0.0 0.024 14.9 0.0 1.6 1 0 0 1 1 1 0 DNA ligase 3 BRCT domain IMS_HHH PF11798.8 EMD63739.1 - 0.084 13.2 0.3 1 9.8 0.2 2.8 2 0 0 2 2 2 0 IMS family HHH motif PTPlike_phytase PF14566.6 EMD63739.1 - 0.11 12.6 1.1 0.26 11.4 0.1 2.1 2 0 0 2 2 2 0 Inositol hexakisphosphate MgtE_N PF03448.17 EMD63739.1 - 0.15 12.7 1.3 35 5.1 0.0 3.6 3 0 0 3 3 3 0 MgtE intracellular N domain FKBP_C PF00254.28 EMD63740.1 - 1.1e-31 109.0 0.0 2.7e-31 107.8 0.0 1.7 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase NPL PF17800.1 EMD63740.1 - 7e-29 100.5 3.4 7e-29 100.5 3.4 2.8 2 2 0 2 2 2 1 Nucleoplasmin-like domain Trypan_PARP PF05887.11 EMD63740.1 - 0.022 14.7 7.6 0.022 14.7 7.6 3.9 4 2 1 5 5 5 0 Procyclic acidic repetitive protein (PARP) HemY_N PF07219.13 EMD63740.1 - 0.39 10.9 1.2 0.86 9.8 1.2 1.6 1 0 0 1 1 1 0 HemY protein N-terminus ODC_AZ PF02100.17 EMD63741.1 - 4.7e-40 136.1 0.3 5.8e-40 135.8 0.3 1.1 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme DEAD_2 PF06733.15 EMD63742.1 - 2e-56 190.4 0.1 3.3e-56 189.7 0.1 1.4 1 0 0 1 1 1 1 DEAD_2 HBB PF06777.11 EMD63742.1 - 2.6e-46 157.7 1.4 4.2e-42 144.0 0.3 2.4 2 0 0 2 2 2 2 Helical and beta-bridge domain Helicase_C_2 PF13307.6 EMD63742.1 - 2.4e-44 151.5 0.0 9.8e-44 149.5 0.0 2.1 2 0 0 2 2 2 1 Helicase C-terminal domain ResIII PF04851.15 EMD63742.1 - 3.6e-05 23.8 0.0 0.0021 18.1 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EMD63742.1 - 0.00027 20.8 0.0 0.029 14.2 0.0 2.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase SNF2_N PF00176.23 EMD63742.1 - 0.0057 15.4 0.0 0.043 12.5 0.0 2.0 1 1 0 1 1 1 1 SNF2 family N-terminal domain AAA_22 PF13401.6 EMD63742.1 - 0.039 14.2 0.5 4.2 7.6 0.1 3.0 2 0 0 2 2 2 0 AAA domain DUF2075 PF09848.9 EMD63742.1 - 0.074 12.3 0.0 3.1 6.9 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) zf-RING_2 PF13639.6 EMD63743.1 - 5.3e-07 29.9 5.7 1e-06 28.9 5.7 1.5 1 0 0 1 1 1 1 Ring finger domain FANCL_C PF11793.8 EMD63743.1 - 2e-05 24.7 2.7 0.00012 22.2 3.1 2.1 2 0 0 2 2 2 1 FANCL C-terminal domain zf-ANAPC11 PF12861.7 EMD63743.1 - 0.0014 18.6 1.4 0.0035 17.4 1.4 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 EMD63743.1 - 0.0071 16.6 4.5 0.016 15.5 4.5 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 EMD63743.1 - 0.013 15.3 5.0 0.028 14.3 5.0 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) XPC-binding PF09280.11 EMD63743.1 - 0.069 12.9 0.7 2.6 7.9 0.3 3.1 2 0 0 2 2 2 0 XPC-binding domain Zn_ribbon_17 PF17120.5 EMD63743.1 - 0.1 12.2 2.9 0.22 11.2 2.9 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING-like PF08746.11 EMD63743.1 - 0.2 12.0 3.9 0.38 11.1 3.9 1.5 1 0 0 1 1 1 0 RING-like domain RINGv PF12906.7 EMD63743.1 - 0.24 11.5 3.6 0.56 10.4 3.6 1.7 1 0 0 1 1 1 0 RING-variant domain NIT PF08376.10 EMD63743.1 - 0.42 11.0 0.0 0.42 11.0 0.0 4.3 5 1 0 5 5 5 0 Nitrate and nitrite sensing C1_1 PF00130.22 EMD63743.1 - 0.66 9.9 3.7 1.4 8.8 3.7 1.5 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-C3HC4_2 PF13923.6 EMD63743.1 - 1 9.3 5.9 2.2 8.2 5.9 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) PHD PF00628.29 EMD63743.1 - 3.8 7.5 4.6 7.2 6.6 4.6 1.5 1 0 0 1 1 1 0 PHD-finger Prok-RING_4 PF14447.6 EMD63743.1 - 4.3 7.3 4.6 8.8 6.3 4.6 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 DSBA PF01323.20 EMD63744.1 - 1.6e-56 191.1 0.0 2.2e-32 112.4 0.0 3.1 3 0 0 3 3 3 3 DSBA-like thioredoxin domain Yippee-Mis18 PF03226.14 EMD63745.1 - 4.9e-14 52.4 0.0 6.5e-14 52.0 0.0 1.2 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly RIG-I_C-RD PF11648.8 EMD63745.1 - 0.065 13.5 0.0 0.087 13.1 0.0 1.2 1 0 0 1 1 1 0 C-terminal domain of RIG-I Pkinase PF00069.25 EMD63747.1 - 1.8e-51 175.1 0.0 7.1e-27 94.4 0.0 3.1 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 EMD63747.1 - 3.4e-22 79.0 0.0 1.1e-13 51.1 0.0 2.9 3 0 0 3 3 3 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 EMD63747.1 - 0.00071 18.5 0.0 0.0011 17.8 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EMD63747.1 - 0.0018 18.2 0.4 0.0054 16.7 0.4 1.9 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.11 EMD63747.1 - 0.012 14.6 0.0 0.018 14.0 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Haspin_kinase PF12330.8 EMD63747.1 - 0.017 14.1 0.1 0.029 13.3 0.1 1.2 1 0 0 1 1 1 0 Haspin like kinase domain RTA1 PF04479.13 EMD63748.1 - 1.6e-67 227.2 3.6 2.5e-67 226.5 3.6 1.3 1 0 0 1 1 1 1 RTA1 like protein DUF4051 PF13260.6 EMD63748.1 - 0.034 13.9 0.1 0.034 13.9 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4051) DUF4328 PF14219.6 EMD63748.1 - 0.052 13.1 0.0 0.17 11.4 0.0 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4328) HemY_N PF07219.13 EMD63748.1 - 0.57 10.4 4.4 6.6 7.0 0.1 3.3 3 0 0 3 3 3 0 HemY protein N-terminus p450 PF00067.22 EMD63750.1 - 2.4e-40 138.7 0.0 3.3e-40 138.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 DUF1151 PF06625.11 EMD63750.1 - 0.065 13.2 1.4 0.16 11.9 1.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1151) Thiamine_BP PF01910.17 EMD63751.1 - 2.6e-31 107.4 0.0 3.1e-31 107.1 0.0 1.1 1 0 0 1 1 1 1 Thiamine-binding protein DUF1335 PF07056.11 EMD63751.1 - 0.082 13.0 0.0 0.29 11.2 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1335) X PF00739.19 EMD63752.1 - 0.11 12.7 0.3 1.8 8.7 0.6 2.5 2 0 0 2 2 2 0 Trans-activation protein X Haspin_kinase PF12330.8 EMD63753.1 - 3.5e-40 138.1 0.0 3.3e-30 105.3 0.0 3.1 2 1 0 2 2 2 2 Haspin like kinase domain Response_reg PF00072.24 EMD63754.1 - 5.7e-20 71.6 0.0 8e-14 51.8 0.0 2.3 2 0 0 2 2 2 2 Response regulator receiver domain APH PF01636.23 EMD63757.1 - 1.7e-06 28.1 0.4 2.7e-06 27.5 0.2 1.4 2 0 0 2 2 2 1 Phosphotransferase enzyme family EcKinase PF02958.20 EMD63757.1 - 0.051 12.9 0.2 0.067 12.5 0.2 1.2 1 0 0 1 1 1 0 Ecdysteroid kinase Rot1 PF10681.9 EMD63757.1 - 0.079 12.5 0.0 0.15 11.5 0.0 1.3 1 1 0 1 1 1 0 Chaperone for protein-folding within the ER, fungal DUF1679 PF07914.11 EMD63757.1 - 0.085 11.7 0.1 0.12 11.2 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) Pkinase PF00069.25 EMD63758.1 - 1.8e-66 224.2 0.0 2.3e-66 223.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD63758.1 - 6.2e-34 117.4 0.0 8.3e-34 117.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EMD63758.1 - 0.0005 19.1 0.0 0.00069 18.7 0.0 1.1 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EMD63758.1 - 0.00091 19.2 0.0 0.018 15.0 0.0 2.4 1 1 1 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EMD63758.1 - 0.0073 15.1 0.0 0.012 14.4 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kinase-PolyVal PF18762.1 EMD63758.1 - 0.027 14.4 0.1 6 6.8 0.0 2.7 2 1 1 3 3 3 0 Serine/Threonine/Tyrosine Kinase found in polyvalent proteins Seadorna_VP7 PF07387.11 EMD63758.1 - 0.066 12.3 0.0 0.14 11.2 0.0 1.4 2 0 0 2 2 2 0 Seadornavirus VP7 Kinase-like PF14531.6 EMD63758.1 - 0.091 12.1 0.0 0.18 11.1 0.0 1.5 2 0 0 2 2 2 0 Kinase-like FTA2 PF13095.6 EMD63758.1 - 0.13 11.8 0.0 1.1 8.8 0.0 2.0 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 ATP-synt_C PF00137.21 EMD63759.1 - 1.6e-30 105.2 36.9 5.6e-19 68.2 15.3 2.1 2 0 0 2 2 2 2 ATP synthase subunit C CNH PF00780.22 EMD63760.1 - 6.2e-81 272.0 0.0 9.6e-80 268.1 0.0 2.1 2 0 0 2 2 2 1 CNH domain PH_5 PF15405.6 EMD63760.1 - 1.5e-48 164.3 2.1 1.7e-48 164.2 0.0 2.2 2 0 0 2 2 2 1 Pleckstrin homology domain RhoGEF PF00621.20 EMD63760.1 - 1.7e-39 136.0 0.3 3.2e-39 135.1 0.3 1.5 1 0 0 1 1 1 1 RhoGEF domain DEP PF00610.21 EMD63760.1 - 2e-14 53.4 0.0 4.4e-14 52.3 0.0 1.6 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) PH PF00169.29 EMD63760.1 - 0.04 14.4 0.1 0.42 11.2 0.0 2.7 1 1 1 2 2 2 0 PH domain EthD PF07110.11 EMD63761.1 - 4.3e-06 27.8 0.1 0.046 14.9 0.1 2.3 2 0 0 2 2 2 2 EthD domain DUF4286 PF14114.6 EMD63761.1 - 0.0039 17.7 0.1 2.4 8.7 0.0 2.9 2 1 0 2 2 2 2 Domain of unknown function (DUF4286) CT_A_B PF02626.15 EMD63762.1 - 2.3e-80 270.0 0.0 3.7e-80 269.4 0.0 1.3 1 0 0 1 1 1 1 Carboxyltransferase domain, subdomain A and B CPSase_L_D2 PF02786.17 EMD63762.1 - 1e-54 185.3 0.0 2.4e-54 184.1 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 EMD63762.1 - 3.7e-41 140.1 0.1 1.1e-40 138.5 0.1 1.9 2 0 0 2 2 2 1 Biotin carboxylase, N-terminal domain CT_C_D PF02682.16 EMD63762.1 - 2.3e-35 122.2 0.0 4.3e-35 121.3 0.0 1.4 1 0 0 1 1 1 1 Carboxyltransferase domain, subdomain C and D Biotin_carb_C PF02785.19 EMD63762.1 - 6.1e-30 103.5 0.0 1.1e-29 102.6 0.0 1.5 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 EMD63762.1 - 9.8e-08 31.7 3.5 3.8e-07 29.9 3.5 2.1 1 0 0 1 1 1 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.13 EMD63762.1 - 7.4e-07 28.9 0.0 1.5e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 EMD63762.1 - 0.0013 18.3 0.0 0.0025 17.4 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain Biotin_lipoyl_2 PF13533.6 EMD63762.1 - 0.0074 16.1 1.6 3.4 7.6 0.2 3.0 1 1 1 2 2 2 2 Biotin-lipoyl like ATP-grasp_5 PF13549.6 EMD63762.1 - 0.022 14.2 0.0 0.047 13.1 0.0 1.4 1 0 0 1 1 1 0 ATP-grasp domain LamB_YcsF PF03746.16 EMD63763.1 - 5.2e-84 281.7 0.0 5.9e-84 281.5 0.0 1.0 1 0 0 1 1 1 1 LamB/YcsF family DUF4224 PF13986.6 EMD63763.1 - 0.067 13.1 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4224) Pkinase PF00069.25 EMD63764.1 - 2.7e-43 148.2 0.0 9e-43 146.5 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD63764.1 - 5.7e-25 88.1 0.0 8.6e-25 87.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EMD63764.1 - 0.012 14.4 0.0 0.024 13.4 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase Kinase-like PF14531.6 EMD63764.1 - 0.095 12.0 0.0 2.6 7.3 0.0 2.3 2 0 0 2 2 2 0 Kinase-like Zw10 PF06248.13 EMD63765.1 - 0.051 12.1 1.9 0.079 11.5 1.9 1.2 1 0 0 1 1 1 0 Centromere/kinetochore Zw10 NPV_P10 PF05531.12 EMD63765.1 - 0.059 13.8 0.5 0.78 10.2 0.2 2.5 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein RPW8 PF05659.11 EMD63765.1 - 0.092 12.4 0.9 0.43 10.3 0.1 2.1 1 1 1 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 Prominin PF05478.11 EMD63765.1 - 1.5 6.7 3.2 2.2 6.1 3.2 1.1 1 0 0 1 1 1 0 Prominin SlyX PF04102.12 EMD63765.1 - 5.9 7.6 6.7 8.5 7.1 0.0 3.7 4 0 0 4 4 4 0 SlyX Med9 PF07544.13 EMD63765.1 - 8.8 6.5 7.4 15 5.8 2.1 2.8 2 1 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 Ras PF00071.22 EMD63766.1 - 1.4e-52 177.6 0.0 1.6e-52 177.3 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMD63766.1 - 5.7e-19 68.5 0.0 8e-19 68.0 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMD63766.1 - 1.3e-06 28.0 0.0 1.8e-06 27.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EMD63766.1 - 0.19 11.3 0.1 1.1 8.8 0.0 2.2 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain Zn_clus PF00172.18 EMD63767.1 - 5.5e-14 52.0 28.4 9.6e-08 32.0 11.8 2.5 2 0 0 2 2 2 2 Fungal Zn(2)-Cys(6) binuclear cluster domain PTN13_u3 PF16599.5 EMD63767.1 - 0.059 13.4 0.0 0.059 13.4 0.0 2.6 2 1 0 3 3 3 0 Unstructured linker region on PTN13 protein between PDZ Glyco_hydro_3_C PF01915.22 EMD63768.1 - 4.5e-52 177.0 0.2 9.6e-52 175.9 0.2 1.6 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain GATase PF00117.28 EMD63768.1 - 3.2e-45 154.2 0.0 5.1e-45 153.6 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I CPSase_sm_chain PF00988.22 EMD63768.1 - 3.9e-44 149.6 0.0 8e-44 148.6 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain Glyco_hydro_3 PF00933.21 EMD63768.1 - 4.9e-39 134.6 0.0 1.1e-38 133.5 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 EMD63768.1 - 1.6e-24 85.8 0.0 3.5e-24 84.7 0.0 1.6 1 0 0 1 1 1 1 Fibronectin type III-like domain 2-oxogl_dehyd_N PF16078.5 EMD63768.1 - 0.0036 16.9 0.1 0.15 11.6 0.0 2.5 2 0 0 2 2 2 1 2-oxoglutarate dehydrogenase N-terminus Peptidase_C26 PF07722.13 EMD63768.1 - 0.019 14.7 0.5 0.063 13.0 0.2 2.0 1 1 1 2 2 2 0 Peptidase C26 Ser_hydrolase PF06821.13 EMD63768.1 - 0.067 13.1 0.3 0.21 11.4 0.2 1.8 1 1 0 1 1 1 0 Serine hydrolase DJ-1_PfpI PF01965.24 EMD63768.1 - 0.12 12.1 0.0 0.3 10.9 0.0 1.6 1 0 0 1 1 1 0 DJ-1/PfpI family CENP-Q PF13094.6 EMD63769.1 - 0.0055 16.9 9.1 0.0055 16.9 9.1 2.0 2 0 0 2 2 2 1 CENP-Q, a CENPA-CAD centromere complex subunit SHE3 PF17078.5 EMD63769.1 - 8.1 6.1 9.4 0.88 9.2 0.3 2.4 3 0 0 3 3 3 0 SWI5-dependent HO expression protein 3 Lebercilin PF15619.6 EMD63769.1 - 9.7 5.8 16.8 1.8 8.2 0.2 2.7 2 1 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease Tmemb_170 PF10190.9 EMD63772.1 - 8.9e-18 64.6 8.9 1.1e-17 64.4 8.9 1.1 1 0 0 1 1 1 1 Putative transmembrane protein 170 SLX9 PF15341.6 EMD63773.1 - 0.19 12.1 2.3 0.44 11.0 0.6 2.0 1 1 0 2 2 2 0 Ribosome biogenesis protein SLX9 NUDIX PF00293.28 EMD63774.1 - 5.5e-05 23.2 0.0 0.00015 21.8 0.0 1.7 1 1 0 1 1 1 1 NUDIX domain Zn_clus PF00172.18 EMD63775.1 - 2.3e-05 24.4 11.6 5.3e-05 23.3 11.6 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EMD63775.1 - 3.9e-05 22.8 0.1 0.00013 21.1 0.1 1.7 1 1 0 1 1 1 1 Fungal specific transcription factor domain DUF3907 PF13047.6 EMD63775.1 - 0.14 12.1 0.0 0.27 11.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3907) DUF5012 PF16404.5 EMD63775.1 - 0.22 11.6 0.0 28 4.8 0.0 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF5012) Fungal_trans PF04082.18 EMD63776.1 - 2.6e-18 66.0 0.2 4.7e-18 65.2 0.2 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD63776.1 - 3.8e-10 39.7 4.8 8.6e-10 38.6 4.8 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ZapB PF06005.12 EMD63776.1 - 0.24 11.9 0.2 0.52 10.8 0.0 1.6 2 0 0 2 2 2 0 Cell division protein ZapB AAT PF03417.16 EMD63777.1 - 5.3e-29 101.5 0.0 6.5e-29 101.2 0.0 1.1 1 0 0 1 1 1 1 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase Polysacc_deac_1 PF01522.21 EMD63778.1 - 2.4e-23 82.4 0.0 3.7e-23 81.8 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide deacetylase DUF2334 PF10096.9 EMD63778.1 - 2e-14 53.8 1.0 3.9e-14 52.8 1.0 1.6 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2334) Glyco_hydro_57 PF03065.15 EMD63778.1 - 3e-06 26.7 0.1 4.8e-06 26.0 0.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 57 DUF2194 PF09960.9 EMD63778.1 - 0.013 13.9 0.1 0.02 13.2 0.1 1.3 1 1 0 1 1 1 0 Uncharacterised protein conserved in bacteria (DUF2194) DUF4023 PF13215.6 EMD63778.1 - 0.14 12.2 0.0 0.65 10.0 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4023) AAA_35 PF14516.6 EMD63778.1 - 0.17 10.7 0.0 0.24 10.2 0.0 1.1 1 0 0 1 1 1 0 AAA-like domain VESA1_N PF12785.7 EMD63779.1 - 0.11 11.4 3.3 0.16 10.9 3.3 1.2 1 0 0 1 1 1 0 Variant erythrocyte surface antigen-1 Acetyltransf_1 PF00583.25 EMD63780.1 - 5.4e-07 29.9 0.0 1.2e-06 28.7 0.0 1.6 1 1 1 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EMD63780.1 - 0.08 13.4 0.0 0.12 12.9 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EMD63780.1 - 0.14 12.1 0.0 0.23 11.4 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Isochorismatase PF00857.20 EMD63781.1 - 1.2e-28 100.5 0.0 1.4e-28 100.2 0.0 1.1 1 0 0 1 1 1 1 Isochorismatase family PAP_assoc PF03828.19 EMD63783.1 - 1e-16 60.9 0.0 2.5e-16 59.6 0.0 1.7 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 EMD63783.1 - 5.9e-05 23.3 0.0 0.00011 22.4 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyltransferase domain Polbeta PF18765.1 EMD63783.1 - 0.068 13.3 0.0 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase FUSC PF04632.12 EMD63783.1 - 0.21 10.1 3.1 0.64 8.5 0.0 2.1 2 0 0 2 2 2 0 Fusaric acid resistance protein family Acetate_kinase PF00871.17 EMD63784.1 - 6.8e-98 327.9 0.0 8.1e-98 327.7 0.0 1.0 1 0 0 1 1 1 1 Acetokinase family Ank_2 PF12796.7 EMD63785.1 - 7.8e-38 128.9 6.1 9.7e-09 35.7 0.0 8.8 7 2 2 9 9 9 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMD63785.1 - 5.2e-26 90.7 6.3 1.3e-07 32.0 0.0 10.3 6 3 5 11 11 11 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMD63785.1 - 3.8e-24 82.1 14.1 0.0015 18.8 0.0 13.4 16 0 0 16 16 16 5 Ankyrin repeat Ank_5 PF13857.6 EMD63785.1 - 3.7e-18 65.3 3.8 0.29 11.5 0.0 9.6 7 3 3 10 10 10 5 Ankyrin repeats (many copies) Ank PF00023.30 EMD63785.1 - 2.1e-16 59.5 8.8 0.014 15.8 0.0 10.7 12 0 0 12 12 12 3 Ankyrin repeat Clr5 PF14420.6 EMD63785.1 - 3e-15 56.2 0.2 6.4e-15 55.1 0.2 1.6 1 0 0 1 1 1 1 Clr5 domain DUF3447 PF11929.8 EMD63785.1 - 0.00037 20.4 0.1 0.063 13.2 0.0 4.3 5 0 0 5 5 5 1 Domain of unknown function (DUF3447) Pyr_redox_2 PF07992.14 EMD63786.1 - 1.9e-36 125.8 0.0 2.4e-36 125.5 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EMD63786.1 - 7.9e-13 48.8 0.2 3e-12 46.9 0.1 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EMD63786.1 - 3.8e-05 23.1 0.0 6e-05 22.4 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EMD63786.1 - 6.3e-05 22.3 0.2 0.00014 21.1 0.0 1.6 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 EMD63786.1 - 0.0045 17.0 0.1 2.9 7.9 0.0 3.6 4 0 0 4 4 4 1 FAD-NAD(P)-binding HI0933_like PF03486.14 EMD63786.1 - 0.081 11.6 2.3 0.71 8.5 0.0 2.8 3 1 0 3 3 3 0 HI0933-like protein RAI16-like PF10257.9 EMD63787.1 - 5.7e-83 278.8 0.5 8.9e-83 278.1 0.5 1.3 1 0 0 1 1 1 1 Retinoic acid induced 16-like protein DinB PF05163.12 EMD63787.1 - 0.032 14.2 0.4 6.3 6.7 0.0 3.0 2 0 0 2 2 2 0 DinB family KinB_sensor PF16767.5 EMD63787.1 - 0.075 13.5 1.0 0.3 11.6 0.2 2.3 2 0 0 2 2 2 0 Sensor domain of alginate biosynthesis sensor protein KinB Mito_carr PF00153.27 EMD63788.1 - 1.5e-68 226.7 2.0 1.3e-23 82.8 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Cofilin_ADF PF00241.20 EMD63789.1 - 4.6e-37 126.5 0.0 1.9e-19 69.6 0.0 2.1 2 0 0 2 2 2 2 Cofilin/tropomyosin-type actin-binding protein BrnA_antitoxin PF14384.6 EMD63789.1 - 0.0022 18.4 0.0 0.0047 17.4 0.0 1.6 1 0 0 1 1 1 1 BrnA antitoxin of type II toxin-antitoxin system HBD PF18534.1 EMD63789.1 - 0.031 14.4 0.0 0.24 11.6 0.1 2.3 2 0 0 2 2 2 0 Helical bundle domain U3_snoRNA_assoc PF08297.11 EMD63790.1 - 1.8e-18 67.0 6.6 1.8e-18 67.0 6.6 5.4 3 2 1 5 5 5 1 U3 snoRNA associated AT_hook PF02178.19 EMD63790.1 - 0.19 11.7 6.7 1.6 8.9 6.7 2.8 1 0 0 1 1 1 0 AT hook motif DUF2749 PF10907.8 EMD63790.1 - 0.26 11.5 1.8 1.7 8.8 1.8 2.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2749) TPR_8 PF13181.6 EMD63791.1 - 1.3e-07 31.3 0.0 0.0054 16.8 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 EMD63791.1 - 0.0021 18.0 0.0 2.7 8.3 0.1 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 EMD63791.1 - 0.011 16.1 0.4 0.17 12.2 0.4 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 EMD63791.1 - 0.021 15.4 0.8 0.63 10.8 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 EMD63791.1 - 0.039 14.0 0.6 0.22 11.6 0.1 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.6 EMD63791.1 - 0.076 13.4 0.0 22 5.7 0.1 4.2 5 0 0 5 5 5 0 Tetratricopeptide repeat Phage_tail_APC PF16778.5 EMD63791.1 - 0.088 12.7 0.9 15 5.6 0.2 2.8 2 0 0 2 2 2 0 Phage tail assembly chaperone protein TPR_14 PF13428.6 EMD63791.1 - 0.45 11.5 2.6 2.7 9.0 0.2 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat Isochorismatase PF00857.20 EMD63792.1 - 2.1e-27 96.4 0.0 1.7e-18 67.4 0.0 2.2 2 0 0 2 2 2 2 Isochorismatase family RdRP PF05183.12 EMD63792.1 - 0.019 13.6 0.0 0.028 13.1 0.0 1.2 1 0 0 1 1 1 0 RNA dependent RNA polymerase ETF PF01012.21 EMD63793.1 - 3.6e-39 134.5 2.9 4.4e-39 134.2 2.9 1.1 1 0 0 1 1 1 1 Electron transfer flavoprotein domain Nucleoside_tran PF01733.18 EMD63794.1 - 6.3e-43 147.3 12.1 2.2e-41 142.2 12.1 2.2 1 1 0 1 1 1 1 Nucleoside transporter MFS_1 PF07690.16 EMD63794.1 - 1.8e-07 30.4 38.4 0.0003 19.8 27.4 2.9 1 1 1 2 2 2 2 Major Facilitator Superfamily PalH PF08733.10 EMD63794.1 - 0.051 12.6 2.1 0.068 12.2 0.0 2.0 1 1 0 1 1 1 0 PalH/RIM21 DUF5493 PF17597.2 EMD63794.1 - 2 8.7 9.0 0.11 12.8 2.7 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5493) Iwr1 PF08574.10 EMD63795.1 - 1.4e-16 61.2 11.9 1.4e-16 61.2 11.9 3.0 2 1 0 2 2 2 1 Transcription factor Iwr1 ubiquitin PF00240.23 EMD63797.1 - 0.0066 16.2 0.0 0.012 15.4 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family PB1 PF00564.24 EMD63797.1 - 0.026 14.5 0.0 0.051 13.5 0.0 1.4 1 0 0 1 1 1 0 PB1 domain Casein_kappa PF00997.18 EMD63797.1 - 0.14 12.2 1.9 0.23 11.5 1.9 1.3 1 0 0 1 1 1 0 Kappa casein HTH_24 PF13412.6 EMD63798.1 - 0.12 11.9 0.0 0.16 11.5 0.0 1.2 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding DUF5326 PF17260.2 EMD63800.1 - 0.025 14.7 0.6 0.025 14.7 0.6 1.7 2 0 0 2 2 2 0 Family of unknown function (DUF5326) Ank_2 PF12796.7 EMD63801.1 - 1e-20 74.1 3.8 1.3e-12 48.2 0.5 2.0 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMD63801.1 - 3.9e-20 72.0 2.6 1.9e-06 28.3 0.1 3.7 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 EMD63801.1 - 8.6e-14 51.3 3.5 0.006 17.0 0.1 4.1 4 0 0 4 4 4 3 Ankyrin repeat Ank_3 PF13606.6 EMD63801.1 - 3.9e-07 29.9 0.7 2.3 9.1 0.0 3.9 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 EMD63801.1 - 9.5e-06 25.8 1.7 0.013 15.8 0.2 2.7 1 1 2 3 3 3 3 Ankyrin repeats (many copies) YajC PF02699.15 EMD63801.1 - 0.031 14.1 0.7 23 5.0 0.0 3.0 1 1 2 3 3 3 0 Preprotein translocase subunit bMG3 PF11974.8 EMD63801.1 - 0.074 13.1 0.3 4.4 7.4 0.1 2.6 1 1 1 2 2 2 0 Bacterial alpha-2-macroglobulin MG3 domain ubiquitin PF00240.23 EMD63802.1 - 2.1e-25 88.3 0.0 2.3e-25 88.1 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EMD63802.1 - 8.4e-16 57.6 0.1 9.2e-16 57.4 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EMD63802.1 - 0.00014 22.2 0.0 0.0004 20.8 0.0 1.7 1 1 0 1 1 1 1 Ubiquitin-like domain TBK1_ULD PF18396.1 EMD63802.1 - 0.0081 16.1 0.0 0.0095 15.8 0.0 1.1 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD_2 PF13881.6 EMD63802.1 - 0.076 13.1 0.0 0.19 11.9 0.0 1.6 1 1 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 EMD63802.1 - 0.14 12.6 0.0 0.31 11.4 0.0 1.6 1 1 0 1 1 1 0 Ubiquitin-like domain Adeno_PX PF05829.12 EMD63804.1 - 0.0097 15.8 0.0 0.02 14.7 0.0 1.5 1 0 0 1 1 1 1 Adenovirus late L2 mu core protein (Protein X) RabGAP-TBC PF00566.18 EMD63805.1 - 7.3e-33 114.0 2.1 1e-32 113.6 0.0 1.9 2 0 0 2 2 2 1 Rab-GTPase-TBC domain CPSF100_C PF13299.6 EMD63805.1 - 0.12 12.5 2.5 0.27 11.4 2.5 1.6 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal RR_TM4-6 PF06459.12 EMD63805.1 - 0.53 10.1 6.1 0.43 10.4 3.5 2.0 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Presenilin PF01080.17 EMD63805.1 - 5.4 5.7 5.3 8.4 5.0 5.3 1.3 1 0 0 1 1 1 0 Presenilin NTPase_P4 PF11602.8 EMD63806.1 - 0.09 12.0 0.0 0.097 11.9 0.0 1.0 1 0 0 1 1 1 0 ATPase P4 of dsRNA bacteriophage phi-12 NFACT-C PF11923.8 EMD63807.1 - 2.3e-39 133.6 0.2 2.3e-39 133.6 0.2 3.9 4 0 0 4 4 4 1 NFACT protein C-terminal domain FbpA PF05833.11 EMD63807.1 - 1.5e-32 113.0 8.6 1.5e-32 113.0 8.6 2.7 2 1 0 2 2 2 1 Fibronectin-binding protein A N-terminus (FbpA) NFACT-R_1 PF05670.13 EMD63807.1 - 1.3e-28 99.9 0.0 5.3e-28 97.8 0.0 2.2 1 0 0 1 1 1 1 NFACT protein RNA binding domain Clat_adaptor_s PF01217.20 EMD63808.1 - 7.5e-14 51.9 0.5 1.3e-13 51.0 0.5 1.4 1 1 0 1 1 1 1 Clathrin adaptor complex small chain Mito_fiss_reg PF05308.11 EMD63809.1 - 0.25 11.4 0.1 0.25 11.4 0.1 2.0 3 0 0 3 3 3 0 Mitochondrial fission regulator Fungal_trans PF04082.18 EMD63810.1 - 2.6e-29 102.1 0.3 6.2e-29 100.8 0.0 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain E1-E2_ATPase PF00122.20 EMD63811.1 - 1.1e-34 119.5 21.5 4.8e-30 104.4 0.3 4.0 4 0 0 4 4 4 2 E1-E2 ATPase Cation_ATPase_C PF00689.21 EMD63811.1 - 4.9e-22 78.5 12.7 4.9e-22 78.5 12.7 2.4 3 1 0 3 3 3 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.6 EMD63811.1 - 8.8e-17 61.0 0.0 1.7e-16 60.0 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EMD63811.1 - 3.1e-16 60.3 0.0 9.7e-15 55.4 0.0 2.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EMD63811.1 - 1.3e-15 56.8 0.0 1.4e-14 53.5 0.0 2.5 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EMD63811.1 - 0.00069 19.4 0.4 0.0041 16.9 0.5 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF4089 PF13318.6 EMD63811.1 - 0.098 13.1 0.1 0.25 11.8 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4089) zf-RING_2 PF13639.6 EMD63812.1 - 4.5e-08 33.3 4.7 6.7e-07 29.5 1.8 2.5 2 0 0 2 2 2 1 Ring finger domain zf-rbx1 PF12678.7 EMD63812.1 - 1.1e-07 32.0 2.1 3.7e-07 30.3 0.7 2.4 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 EMD63812.1 - 5.7e-06 26.1 5.6 0.00011 22.0 2.0 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMD63812.1 - 1.5e-05 24.8 6.1 0.00021 21.1 2.6 3.2 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EMD63812.1 - 1.6e-05 24.9 0.9 2.8e-05 24.1 0.2 1.8 2 0 0 2 2 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.5 EMD63812.1 - 0.00066 19.4 6.3 0.018 14.8 0.2 3.0 3 0 0 3 3 3 2 RING-like zinc finger zf-RING_5 PF14634.6 EMD63812.1 - 0.0063 16.5 0.4 0.0063 16.5 0.4 2.5 3 0 0 3 3 3 1 zinc-RING finger domain OSTbeta PF15048.6 EMD63812.1 - 0.016 15.3 0.1 0.21 11.7 0.0 2.2 2 0 0 2 2 2 0 Organic solute transporter subunit beta protein Zn_ribbon_17 PF17120.5 EMD63812.1 - 0.036 13.7 0.7 0.036 13.7 0.7 2.2 3 0 0 3 3 2 0 Zinc-ribbon, C4HC2 type FANCL_C PF11793.8 EMD63812.1 - 0.11 12.7 4.7 3.4 7.9 4.1 3.0 2 1 1 3 3 3 0 FANCL C-terminal domain zf-RING_UBOX PF13445.6 EMD63812.1 - 0.14 12.2 9.0 0.18 11.9 0.1 3.4 3 0 0 3 3 3 0 RING-type zinc-finger Nrap PF03813.14 EMD63812.1 - 0.24 11.4 1.0 0.46 10.5 1.0 1.5 1 0 0 1 1 1 0 Nrap protein domain 1 zf-C3HC4_3 PF13920.6 EMD63812.1 - 0.29 11.0 7.0 0.13 12.1 0.6 2.8 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) RINGv PF12906.7 EMD63812.1 - 1.1 9.4 6.3 0.11 12.6 1.0 2.1 2 0 0 2 2 2 0 RING-variant domain Opi1 PF08618.10 EMD63812.1 - 4.7 6.4 12.1 0.086 12.1 2.2 2.2 2 0 0 2 2 2 0 Transcription factor Opi1 TMEM171 PF15471.6 EMD63812.1 - 5.2 6.0 6.9 10 5.0 6.9 1.4 1 0 0 1 1 1 0 Transmembrane protein family 171 Prok-RING_4 PF14447.6 EMD63812.1 - 5.6 6.9 7.9 0.15 12.0 0.7 2.0 3 0 0 3 3 3 0 Prokaryotic RING finger family 4 DDHD PF02862.17 EMD63813.1 - 1.6e-60 205.1 5.8 2.5e-59 201.2 0.0 2.6 2 1 0 2 2 2 1 DDHD domain WWE PF02825.20 EMD63813.1 - 0.027 15.1 0.0 0.093 13.3 0.0 1.9 1 0 0 1 1 1 0 WWE domain RNase_3_N PF18497.1 EMD63813.1 - 0.082 13.1 0.0 0.17 12.2 0.0 1.4 1 0 0 1 1 1 0 Ribonuclease III N-terminal domain Hydrolase_4 PF12146.8 EMD63813.1 - 0.17 11.1 0.0 0.3 10.3 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 DUF676 PF05057.14 EMD63813.1 - 0.18 11.3 0.0 0.98 8.9 0.0 2.1 3 0 0 3 3 3 0 Putative serine esterase (DUF676) MAPEG PF01124.18 EMD63815.1 - 2e-17 63.3 5.0 3.8e-17 62.4 5.0 1.4 1 1 0 1 1 1 1 MAPEG family Pesticin PF16754.5 EMD63815.1 - 0.069 13.1 0.0 0.1 12.6 0.0 1.2 1 0 0 1 1 1 0 Bacterial toxin homologue of phage lysozyme, C-term ACPS PF01648.20 EMD63816.1 - 6.8e-07 29.4 0.0 2.9e-06 27.4 0.0 2.0 1 1 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily SNO PF01174.19 EMD63817.1 - 6.8e-54 182.6 0.0 2.5e-44 151.4 0.0 2.1 2 0 0 2 2 2 2 SNO glutamine amidotransferase family GATase_3 PF07685.14 EMD63817.1 - 2.2e-09 37.2 0.0 3.1e-08 33.5 0.0 2.0 2 0 0 2 2 2 1 CobB/CobQ-like glutamine amidotransferase domain GATase PF00117.28 EMD63817.1 - 0.00011 22.1 0.1 0.00036 20.3 0.1 1.7 1 1 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_S51 PF03575.17 EMD63817.1 - 0.0013 18.4 0.0 0.0022 17.7 0.0 1.4 1 0 0 1 1 1 1 Peptidase family S51 DJ-1_PfpI PF01965.24 EMD63817.1 - 0.013 15.3 0.0 0.021 14.6 0.0 1.4 1 0 0 1 1 1 0 DJ-1/PfpI family RRM_1 PF00076.22 EMD63818.1 - 1.7e-16 59.8 0.0 2.4e-16 59.3 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup54 PF13874.6 EMD63819.1 - 0.013 15.6 1.7 0.013 15.6 1.7 2.5 2 0 0 2 2 2 0 Nucleoporin complex subunit 54 FliD_C PF07195.12 EMD63819.1 - 1.1 8.6 5.9 0.093 12.1 0.8 1.7 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 C-terminus dsDNA_bind PF01984.20 EMD63819.1 - 1.1 9.5 9.9 0.82 10.0 3.8 2.8 1 1 1 2 2 2 0 Double-stranded DNA-binding domain SRR1 PF07985.12 EMD63821.1 - 4.3e-17 61.9 0.0 8.6e-17 60.9 0.0 1.5 1 0 0 1 1 1 1 SRR1 Transgly PF00912.22 EMD63821.1 - 0.15 11.5 0.1 0.24 10.8 0.1 1.2 1 0 0 1 1 1 0 Transglycosylase DUF2040 PF09745.9 EMD63822.1 - 1.7e-36 124.9 27.3 1.7e-36 124.9 27.3 4.1 2 2 1 4 4 4 1 Coiled-coil domain-containing protein 55 (DUF2040) OmpH PF03938.14 EMD63823.1 - 0.022 15.1 5.8 0.022 15.1 5.8 1.7 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Glyco_hydro_11 PF00457.17 EMD63824.1 - 5.7e-78 260.6 18.1 6.7e-78 260.4 18.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 11 EBP PF05241.12 EMD63825.1 - 2.1e-69 232.5 11.1 2.5e-69 232.3 11.1 1.0 1 0 0 1 1 1 1 Emopamil binding protein CBM_21 PF03370.13 EMD63826.1 - 4e-36 123.6 2.6 6.4e-36 123.0 2.6 1.3 1 0 0 1 1 1 1 Carbohydrate/starch-binding module (family 21) CBM53 PF16760.5 EMD63826.1 - 8.5e-09 35.9 2.8 1.9e-08 34.8 2.8 1.5 1 0 0 1 1 1 1 Starch/carbohydrate-binding module (family 53) BolA PF01722.18 EMD63830.1 - 8.3e-12 45.2 0.0 2.3e-11 43.8 0.0 1.6 1 1 0 1 1 1 1 BolA-like protein F-box-like PF12937.7 EMD63831.1 - 1.5e-07 31.2 0.2 6.7e-06 25.9 0.0 2.6 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EMD63831.1 - 0.0063 16.4 0.1 0.021 14.7 0.1 1.9 1 0 0 1 1 1 1 F-box domain Toxin_33 PF08121.11 EMD63833.1 - 0.37 10.6 4.5 0.98 9.3 4.5 1.7 1 0 0 1 1 1 0 Waglerin family bVLRF1 PF18826.1 EMD63834.1 - 3.7e-62 208.6 0.4 3.7e-62 208.6 0.4 1.8 2 0 0 2 2 2 1 bacteroidetes VLRF1 release factor Ank_5 PF13857.6 EMD63834.1 - 1.9e-06 28.0 0.1 5.5e-06 26.6 0.1 1.8 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMD63834.1 - 0.00099 19.4 0.0 0.0027 18.0 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeat Ank PF00023.30 EMD63834.1 - 0.0014 19.0 0.5 0.0033 17.8 0.5 1.7 1 0 0 1 1 1 1 Ankyrin repeat Ank_2 PF12796.7 EMD63834.1 - 0.022 15.3 0.0 0.053 14.1 0.0 1.5 1 0 0 1 1 1 0 Ankyrin repeats (3 copies) CBP4 PF07960.11 EMD63834.1 - 6.9 6.5 14.8 12 5.8 0.3 3.4 4 0 0 4 4 4 0 CBP4 FAD_binding_1 PF00667.20 EMD63835.1 - 2.5e-34 118.8 0.0 3.7e-34 118.2 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 EMD63835.1 - 7.8e-30 104.0 0.0 3.5e-29 101.9 0.0 2.0 2 0 0 2 2 2 1 Flavodoxin NAD_binding_1 PF00175.21 EMD63835.1 - 2e-15 57.4 0.0 6.7e-15 55.7 0.0 1.9 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain Flavodoxin_3 PF12641.7 EMD63835.1 - 0.001 18.8 0.0 0.043 13.5 0.0 2.2 2 0 0 2 2 2 1 Flavodoxin domain Flavodoxin_5 PF12724.7 EMD63835.1 - 0.0026 18.0 0.0 0.46 10.7 0.0 2.6 1 1 1 2 2 2 2 Flavodoxin domain RRM_1 PF00076.22 EMD63836.1 - 9.5e-28 95.8 0.1 1.2e-14 53.9 0.0 3.3 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EMD63836.1 - 0.00092 18.8 0.0 0.55 9.8 0.0 3.2 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EMD63836.1 - 0.0034 17.5 0.0 0.27 11.4 0.0 2.5 2 0 0 2 2 2 1 RNA recognition motif Limkain-b1 PF11608.8 EMD63836.1 - 0.17 12.0 0.0 24 5.1 0.0 2.7 3 0 0 3 3 3 0 Limkain b1 Zip PF02535.22 EMD63837.1 - 1.4e-32 113.2 30.2 9e-26 90.9 8.3 3.8 2 1 1 3 3 3 3 ZIP Zinc transporter Hat1_N PF10394.9 EMD63838.1 - 6.5e-35 120.7 0.2 1.7e-34 119.4 0.0 1.8 2 0 0 2 2 2 1 Histone acetyl transferase HAT1 N-terminus Spc7 PF08317.11 EMD63838.1 - 0.006 15.5 1.5 0.006 15.5 1.5 1.9 2 0 0 2 2 2 1 Spc7 kinetochore protein Acetyltransf_1 PF00583.25 EMD63838.1 - 0.0064 16.7 0.0 0.61 10.3 0.0 2.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Formyl_trans_N PF00551.19 EMD63839.1 - 1.4e-43 148.8 0.0 1.6e-43 148.5 0.0 1.1 1 0 0 1 1 1 1 Formyl transferase p450 PF00067.22 EMD63840.1 - 3.5e-70 237.0 0.0 4.3e-70 236.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Terpene_synth_C PF03936.16 EMD63841.1 - 0.081 12.3 0.1 0.1 11.9 0.1 1.2 1 0 0 1 1 1 0 Terpene synthase family, metal binding domain Luciferase_N PF05295.11 EMD63841.1 - 0.12 12.5 0.2 14 5.7 0.0 2.2 2 0 0 2 2 2 0 Luciferase/LBP N-terminal domain SseC PF04888.12 EMD63842.1 - 7.9 6.0 7.3 10 5.6 7.3 1.1 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family WD40 PF00400.32 EMD63843.1 - 4.3e-39 131.8 24.9 1.3e-07 32.1 0.1 7.0 6 0 0 6 6 6 6 WD domain, G-beta repeat F-box-like PF12937.7 EMD63843.1 - 7.8e-11 41.7 0.8 1.4e-10 40.9 0.8 1.5 1 0 0 1 1 1 1 F-box-like Nup160 PF11715.8 EMD63843.1 - 1.3e-08 34.0 3.5 1.3 7.6 0.0 5.9 1 1 5 6 6 6 4 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 EMD63843.1 - 3.2e-08 33.8 0.9 0.21 11.9 0.0 5.8 2 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain F-box PF00646.33 EMD63843.1 - 5.3e-07 29.3 0.6 1e-06 28.5 0.6 1.5 1 0 0 1 1 1 1 F-box domain WD40_like PF17005.5 EMD63843.1 - 0.00042 19.8 0.0 0.018 14.4 0.0 2.7 1 1 3 4 4 4 2 WD40-like domain Abhydrolase_1 PF00561.20 EMD63844.1 - 8e-47 160.0 0.0 2.1e-46 158.7 0.0 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Esterase PF00756.20 EMD63844.1 - 0.00011 21.9 0.0 0.0002 21.1 0.0 1.4 1 0 0 1 1 1 1 Putative esterase Senescence PF06911.12 EMD63845.1 - 0.043 14.1 0.0 0.057 13.7 0.0 1.2 1 0 0 1 1 1 0 Senescence-associated protein FluMu_N PF17891.1 EMD63845.1 - 0.062 13.1 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 Mu-like prophage FluMu N-terminal domain UCH PF00443.29 EMD63846.1 - 9.8e-36 123.5 0.2 1.8e-35 122.7 0.2 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DUF3517 PF12030.8 EMD63846.1 - 1.3e-29 103.2 0.1 6.3e-29 100.9 0.0 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF3517) UCH_1 PF13423.6 EMD63846.1 - 1.8e-21 77.1 0.4 1.8e-21 77.1 0.4 2.0 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Mito_carr PF00153.27 EMD63847.1 - 2.2e-47 158.9 4.3 2.7e-16 59.2 0.2 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF1495 PF07381.11 EMD63848.1 - 0.1 12.4 7.4 18 5.2 0.1 4.5 2 1 3 5 5 5 0 Winged helix DNA-binding domain (DUF1495) ILVD_EDD PF00920.21 EMD63849.1 - 7.5e-213 707.8 1.3 8.7e-213 707.6 1.3 1.0 1 0 0 1 1 1 1 Dehydratase family 5_nucleotid_C PF02872.18 EMD63849.1 - 0.013 15.7 0.1 0.58 10.3 0.0 2.5 2 0 0 2 2 2 0 5'-nucleotidase, C-terminal domain DJ-1_PfpI PF01965.24 EMD63851.1 - 6.3e-18 65.1 0.0 7.9e-18 64.8 0.0 1.1 1 0 0 1 1 1 1 DJ-1/PfpI family DAO PF01266.24 EMD63852.1 - 7.7e-47 160.6 0.4 9.1e-47 160.3 0.4 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EMD63852.1 - 1.2e-05 24.7 0.3 0.002 17.4 0.1 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EMD63852.1 - 5.9e-05 22.4 0.0 0.00013 21.3 0.0 1.5 1 0 0 1 1 1 1 Thi4 family NAD_binding_8 PF13450.6 EMD63852.1 - 6.9e-05 23.0 0.1 0.00015 21.9 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 EMD63852.1 - 0.00079 18.8 0.1 0.0027 17.0 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase MCRA PF06100.11 EMD63852.1 - 0.00094 18.1 0.4 0.0018 17.1 0.1 1.6 2 0 0 2 2 2 1 MCRA family HI0933_like PF03486.14 EMD63852.1 - 0.015 14.0 0.5 0.085 11.5 0.0 2.1 2 0 0 2 2 2 0 HI0933-like protein DUF3530 PF12048.8 EMD63852.1 - 0.029 13.8 0.0 0.046 13.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3530) Pyr_redox PF00070.27 EMD63852.1 - 0.056 14.0 2.2 6.6 7.4 0.1 3.3 2 1 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EMD63852.1 - 0.096 11.9 0.1 0.15 11.3 0.1 1.2 1 0 0 1 1 1 0 FAD binding domain Amino_oxidase PF01593.24 EMD63852.1 - 0.12 11.7 0.2 0.23 10.7 0.0 1.5 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase FAD_binding_2 PF00890.24 EMD63852.1 - 0.12 11.4 1.5 0.41 9.7 1.5 1.8 1 1 0 1 1 1 0 FAD binding domain NAD_binding_9 PF13454.6 EMD63852.1 - 0.13 12.2 0.1 0.65 10.0 0.0 2.0 2 0 0 2 2 2 0 FAD-NAD(P)-binding K_oxygenase PF13434.6 EMD63852.1 - 0.16 11.1 0.0 0.63 9.1 0.0 1.8 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) DUF4217 PF13959.6 EMD63853.1 - 0.084 13.1 0.1 0.35 11.1 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4217) PRCC PF10253.9 EMD63855.1 - 4.6e-25 89.7 24.6 6.2e-23 82.7 24.6 3.6 1 1 0 1 1 1 1 Mitotic checkpoint regulator, MAD2B-interacting CRIM PF16978.5 EMD63856.1 - 2.4e-39 134.7 0.0 5e-39 133.7 0.0 1.6 1 0 0 1 1 1 1 SAPK-interacting protein 1 (Sin1), middle CRIM domain SIN1_PH PF16979.5 EMD63856.1 - 2.3e-29 101.9 0.1 3.8e-29 101.2 0.1 1.3 1 0 0 1 1 1 1 SAPK-interacting protein 1 (Sin1), Pleckstrin-homology Lipase_GDSL_2 PF13472.6 EMD63857.1 - 2.2e-20 73.8 0.1 3.7e-20 73.1 0.1 1.4 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EMD63857.1 - 3.5e-08 33.7 0.0 6.9e-08 32.7 0.0 1.5 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase CBFD_NFYB_HMF PF00808.23 EMD63858.1 - 1.7e-14 53.8 0.7 3.3e-14 52.9 0.7 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EMD63858.1 - 0.00019 21.8 0.3 0.00019 21.8 0.3 2.0 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 Acyltransferase PF01553.21 EMD63859.1 - 0.00012 21.7 0.0 0.00036 20.2 0.0 1.9 1 1 0 1 1 1 1 Acyltransferase zf-NOSIP PF15906.5 EMD63860.1 - 8.5e-07 29.0 0.0 2.2e-06 27.7 0.0 1.7 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein zf-RING_5 PF14634.6 EMD63860.1 - 0.00023 21.0 7.2 0.00023 21.0 7.2 3.0 2 1 0 2 2 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 EMD63860.1 - 0.00024 20.9 3.6 0.00024 20.9 3.6 2.9 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EMD63860.1 - 0.0003 21.1 20.5 0.00043 20.6 7.3 2.9 3 1 0 3 3 2 2 Ring finger domain zf-RING_UBOX PF13445.6 EMD63860.1 - 0.00041 20.3 6.1 0.00041 20.3 6.1 2.9 2 1 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EMD63860.1 - 0.00079 19.2 4.3 0.00079 19.2 4.3 3.2 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EMD63860.1 - 0.00081 19.2 19.1 0.002 17.9 7.7 3.0 2 1 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) FYVE PF01363.21 EMD63860.1 - 0.033 14.3 10.8 0.15 12.2 5.2 3.1 2 1 1 3 3 3 0 FYVE zinc finger YwqJ-deaminase PF14431.6 EMD63860.1 - 0.038 14.2 1.4 0.12 12.6 0.3 2.3 2 0 0 2 2 2 0 YwqJ-like deaminase MAGE_N PF12440.8 EMD63860.1 - 0.47 11.2 8.3 2.3 9.0 0.5 2.8 2 0 0 2 2 2 0 Melanoma associated antigen family N terminal zinc-ribbons_6 PF07191.12 EMD63860.1 - 6.3 6.9 13.1 6.7 6.8 3.4 3.3 2 1 0 2 2 2 0 zinc-ribbons MFS_1 PF07690.16 EMD63861.1 - 6.3e-29 101.0 37.0 6.3e-29 101.0 37.0 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily Root_cap PF06830.11 EMD63861.1 - 0.1 12.7 0.1 0.21 11.7 0.1 1.5 1 0 0 1 1 1 0 Root cap F-box PF00646.33 EMD63863.1 - 3.4e-05 23.6 1.5 3.6e-05 23.5 0.1 1.8 2 0 0 2 2 2 1 F-box domain F-box_4 PF15966.5 EMD63863.1 - 0.013 15.4 0.1 0.013 15.4 0.1 1.9 2 0 0 2 2 2 0 F-box PhoLip_ATPase_C PF16212.5 EMD63864.1 - 5e-83 278.7 17.9 5e-83 278.7 17.9 2.4 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EMD63864.1 - 7.6e-29 99.2 5.5 2.3e-28 97.7 5.5 1.9 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 EMD63864.1 - 5.7e-12 46.4 0.7 2.2e-07 31.4 0.3 3.0 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EMD63864.1 - 8.5e-11 41.8 0.0 5.4e-10 39.2 0.0 2.2 2 0 0 2 2 2 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 EMD63864.1 - 1.5e-06 27.9 0.0 3.3e-06 26.7 0.0 1.6 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase_3 PF08282.12 EMD63864.1 - 0.0018 18.1 0.4 0.022 14.5 0.1 2.3 1 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Aldo_ket_red PF00248.21 EMD63865.1 - 1.1e-40 139.7 0.0 2e-40 138.8 0.0 1.4 1 1 0 1 1 1 1 Aldo/keto reductase family F-box-like PF12937.7 EMD63868.1 - 0.0001 22.1 1.0 0.0001 22.1 1.0 1.9 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EMD63868.1 - 0.00025 20.8 2.3 0.00032 20.5 1.1 1.9 1 1 1 2 2 2 1 F-box domain Sec61_beta PF03911.16 EMD63869.1 - 4.3e-17 61.8 1.5 6.7e-17 61.2 1.5 1.3 1 0 0 1 1 1 1 Sec61beta family COX4_pro PF03626.14 EMD63870.1 - 0.22 12.0 9.9 1 9.8 3.0 3.4 2 2 1 3 3 3 0 Prokaryotic Cytochrome C oxidase subunit IV AA_permease_2 PF13520.6 EMD63871.1 - 1.2e-59 202.2 46.1 1.6e-59 201.8 46.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EMD63871.1 - 2.3e-26 92.5 38.8 2.3e-26 92.5 38.8 1.3 1 1 0 1 1 1 1 Amino acid permease Pyr_redox_2 PF07992.14 EMD63872.1 - 7.3e-26 91.1 0.9 2e-25 89.7 0.9 1.7 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EMD63872.1 - 7.7e-10 39.2 0.0 1.1e-08 35.5 0.1 2.6 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EMD63872.1 - 1.1e-07 31.4 0.1 0.00038 19.8 0.0 2.2 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EMD63872.1 - 4.6e-05 22.6 0.2 0.19 10.8 0.1 2.2 1 1 1 2 2 2 2 Lycopene cyclase protein K_oxygenase PF13434.6 EMD63872.1 - 0.00019 20.7 0.5 0.00036 19.8 0.0 1.8 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 EMD63872.1 - 0.007 16.4 2.1 1.4 8.8 0.0 3.7 4 1 0 4 4 4 1 FAD-NAD(P)-binding GIDA PF01134.22 EMD63872.1 - 0.05 12.7 0.0 4.2 6.4 0.0 2.6 3 0 0 3 3 3 0 Glucose inhibited division protein A 2-Hacid_dh_C PF02826.19 EMD63872.1 - 0.052 12.9 0.1 0.26 10.6 0.1 2.0 1 1 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain FMO-like PF00743.19 EMD63872.1 - 0.11 10.9 0.0 0.16 10.4 0.0 1.2 1 0 0 1 1 1 0 Flavin-binding monooxygenase-like Trp_halogenase PF04820.14 EMD63872.1 - 0.12 11.2 0.8 6.9 5.4 0.2 2.2 2 0 0 2 2 2 0 Tryptophan halogenase DAO PF01266.24 EMD63872.1 - 0.13 11.8 1.1 2.6 7.6 0.2 2.9 3 1 1 4 4 4 0 FAD dependent oxidoreductase Cwf_Cwc_15 PF04889.12 EMD63873.1 - 8.5e-05 22.4 7.5 0.00013 21.8 7.5 1.2 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein Apt1 PF10351.9 EMD63873.1 - 0.36 9.6 13.1 0.46 9.3 13.1 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain TFIIA PF03153.13 EMD63873.1 - 0.41 10.6 10.9 0.56 10.1 10.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Macoilin PF09726.9 EMD63873.1 - 8.6 4.8 11.9 12 4.4 11.9 1.2 1 0 0 1 1 1 0 Macoilin family adh_short PF00106.25 EMD63874.1 - 1.4e-20 73.6 0.0 3.5e-20 72.3 0.0 1.6 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD63874.1 - 3.1e-14 53.1 0.0 5.4e-14 52.3 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD63874.1 - 8.1e-09 35.6 0.0 1.2e-08 35.1 0.0 1.4 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EMD63874.1 - 0.00018 20.7 0.0 0.00028 20.1 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.21 EMD63874.1 - 0.00053 19.5 0.0 0.00081 18.9 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family HAD_2 PF13419.6 EMD63875.1 - 6.7e-11 42.6 0.0 4.9e-10 39.8 0.0 2.3 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EMD63875.1 - 0.0062 16.8 0.0 0.11 12.7 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase COesterase PF00135.28 EMD63876.1 - 1.1e-75 255.5 0.0 1.7e-75 254.9 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EMD63876.1 - 5.6e-09 36.2 0.0 1.1e-08 35.2 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Glyco_hydro_43 PF04616.14 EMD63877.1 - 1.8e-29 102.9 0.6 2.4e-29 102.6 0.6 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 Glyco_hydro_32N PF00251.20 EMD63877.1 - 0.06 12.9 0.5 0.085 12.4 0.5 1.3 1 0 0 1 1 1 0 Glycosyl hydrolases family 32 N-terminal domain PS-DH PF14765.6 EMD63878.1 - 6.8e-70 235.7 0.0 1.1e-69 235.0 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase KR PF08659.10 EMD63878.1 - 2.1e-63 213.5 0.4 7.3e-63 211.7 0.1 2.2 2 0 0 2 2 2 1 KR domain ketoacyl-synt PF00109.26 EMD63878.1 - 2.4e-50 171.5 0.4 2.3e-48 165.0 0.4 3.2 2 1 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 EMD63878.1 - 1.5e-44 152.8 0.1 2.5e-44 152.1 0.1 1.3 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EMD63878.1 - 9.5e-38 128.9 0.0 2.4e-37 127.5 0.0 1.8 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 EMD63878.1 - 7.4e-16 58.6 0.0 2.1e-15 57.1 0.0 1.8 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension ADH_zinc_N_2 PF13602.6 EMD63878.1 - 2.9e-13 51.0 0.5 9.5e-10 39.6 0.1 4.3 5 0 0 5 5 4 1 Zinc-binding dehydrogenase adh_short PF00106.25 EMD63878.1 - 2.1e-12 46.9 0.0 5.3e-12 45.6 0.0 1.6 1 0 0 1 1 1 1 short chain dehydrogenase Methyltransf_12 PF08242.12 EMD63878.1 - 2.7e-12 47.3 0.0 8.5e-12 45.7 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain ADH_zinc_N PF00107.26 EMD63878.1 - 7.8e-12 45.3 1.4 4.2e-11 42.9 0.1 3.0 4 0 0 4 4 3 1 Zinc-binding dehydrogenase Methyltransf_23 PF13489.6 EMD63878.1 - 9e-10 38.6 0.0 2.3e-09 37.3 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMD63878.1 - 3.1e-09 37.4 0.0 3.5e-08 34.0 0.0 2.8 2 0 0 2 2 2 1 Methyltransferase domain PP-binding PF00550.25 EMD63878.1 - 4.2e-07 30.2 0.0 1.3e-06 28.7 0.0 1.9 1 0 0 1 1 1 1 Phosphopantetheine attachment site Methyltransf_11 PF08241.12 EMD63878.1 - 1.8e-06 28.5 0.0 1.3e-05 25.7 0.0 2.6 3 0 0 3 3 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMD63878.1 - 7.1e-06 25.9 0.0 3.5e-05 23.6 0.0 2.3 3 0 0 3 3 1 1 Methyltransferase domain adh_short_C2 PF13561.6 EMD63878.1 - 9.8e-06 25.3 0.3 4.6e-05 23.1 0.0 2.3 3 0 0 3 3 3 1 Enoyl-(Acyl carrier protein) reductase Sacchrp_dh_NADP PF03435.18 EMD63878.1 - 6.9e-05 23.1 0.1 0.00023 21.4 0.1 1.9 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain ADH_N PF08240.12 EMD63878.1 - 0.0011 18.8 0.1 0.0035 17.2 0.1 1.9 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain 3Beta_HSD PF01073.19 EMD63878.1 - 0.0013 17.8 0.0 0.0025 16.9 0.0 1.4 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 EMD63878.1 - 0.012 14.7 0.0 0.021 14.0 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Epimerase PF01370.21 EMD63878.1 - 0.014 14.9 0.0 0.031 13.7 0.0 1.6 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family CoA_trans PF01144.23 EMD63878.1 - 0.045 13.2 0.1 1.8 7.9 0.0 2.9 3 0 0 3 3 3 0 Coenzyme A transferase PCMT PF01135.19 EMD63878.1 - 0.052 13.3 0.0 0.55 10.0 0.0 2.3 2 0 0 2 2 2 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Thiolase_N PF00108.23 EMD63878.1 - 0.11 11.8 1.2 0.47 9.8 0.1 2.3 2 0 0 2 2 2 0 Thiolase, N-terminal domain DUF5319 PF17252.2 EMD63878.1 - 0.12 12.6 0.0 0.86 9.8 0.0 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5319) ketoacyl-synt PF00109.26 EMD63879.1 - 1.9e-63 214.4 0.1 3.6e-63 213.5 0.1 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 EMD63879.1 - 1.4e-30 105.7 0.1 3.3e-30 104.5 0.1 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain HTH_51 PF18558.1 EMD63879.1 - 1.7e-29 101.5 0.0 3.5e-29 100.5 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain Acyl_transf_1 PF00698.21 EMD63879.1 - 8.1e-27 94.6 0.0 2.4e-26 93.0 0.0 1.7 1 0 0 1 1 1 1 Acyl transferase domain Methyltransf_12 PF08242.12 EMD63879.1 - 2e-15 57.3 0.0 9.5e-15 55.1 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain SAT PF16073.5 EMD63879.1 - 1.3e-13 51.3 6.8 3.4e-10 40.1 0.4 4.5 5 1 0 5 5 5 2 Starter unit:ACP transacylase in aflatoxin biosynthesis PP-binding PF00550.25 EMD63879.1 - 1.6e-10 41.2 0.2 3.8e-10 40.0 0.2 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site Methyltransf_25 PF13649.6 EMD63879.1 - 7.5e-10 39.4 0.0 9e-09 35.9 0.0 2.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMD63879.1 - 7.9e-09 36.1 0.0 2.7e-08 34.3 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain KAsynt_C_assoc PF16197.5 EMD63879.1 - 7.9e-08 32.7 0.0 2.1e-07 31.3 0.0 1.7 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Methyltransf_31 PF13847.6 EMD63879.1 - 1.9e-07 31.0 0.0 4.3e-07 29.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EMD63879.1 - 4.7e-07 29.8 0.0 1.8e-06 27.9 0.0 2.0 2 0 0 2 2 1 1 Methyltransferase domain PS-DH PF14765.6 EMD63879.1 - 3.3e-05 23.3 0.0 5.1e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase Thiolase_N PF00108.23 EMD63879.1 - 0.00031 20.2 0.9 0.0012 18.3 0.1 2.3 3 0 0 3 3 3 1 Thiolase, N-terminal domain NodS PF05401.11 EMD63879.1 - 0.019 14.6 0.0 0.046 13.3 0.0 1.5 1 0 0 1 1 1 0 Nodulation protein S (NodS) DUF4072 PF13284.6 EMD63879.1 - 0.14 12.7 0.3 0.54 10.7 0.0 2.3 2 0 0 2 2 1 0 Domain of unknown function (DUF4072) ACP_syn_III PF08545.10 EMD63879.1 - 0.17 11.8 0.5 0.48 10.3 0.5 1.8 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III NAD_binding_4 PF07993.12 EMD63880.1 - 6.2e-08 32.1 0.0 8.6e-08 31.7 0.0 1.2 1 0 0 1 1 1 1 Male sterility protein zf-CCHC PF00098.23 EMD63882.1 - 0.1 12.7 0.3 0.15 12.2 0.3 1.2 1 0 0 1 1 1 0 Zinc knuckle Alba PF01918.21 EMD63882.1 - 0.12 12.2 0.0 0.19 11.6 0.0 1.3 1 0 0 1 1 1 0 Alba Fungal_trans PF04082.18 EMD63883.1 - 3.6e-20 72.1 3.0 5.7e-20 71.5 3.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD63883.1 - 2.9e-07 30.5 9.5 5.4e-07 29.6 9.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ADH_N PF08240.12 EMD63885.1 - 7.4e-11 41.9 0.4 6.7e-10 38.8 0.1 2.5 2 1 1 3 3 3 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EMD63885.1 - 2.9e-08 33.8 0.1 4.8e-08 33.0 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 EMD63885.1 - 0.046 13.6 0.1 0.087 12.7 0.1 1.4 1 0 0 1 1 1 0 N-terminal domain of oxidoreductase Epimerase PF01370.21 EMD63886.1 - 3.6e-14 52.8 0.0 6.5e-14 52.0 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EMD63886.1 - 7e-12 44.9 0.0 1.4e-11 43.9 0.0 1.4 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 EMD63886.1 - 1.5e-08 34.1 0.0 0.00091 18.5 0.0 2.1 2 0 0 2 2 2 2 Male sterility protein GDP_Man_Dehyd PF16363.5 EMD63886.1 - 8.7e-07 28.6 0.0 1.5e-06 27.9 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 EMD63886.1 - 3.1e-06 27.2 0.0 6.2e-06 26.2 0.0 1.4 1 1 0 1 1 1 1 NAD(P)H-binding RmlD_sub_bind PF04321.17 EMD63886.1 - 0.0018 17.4 0.1 0.0058 15.8 0.0 1.8 1 1 1 2 2 2 1 RmlD substrate binding domain NmrA PF05368.13 EMD63886.1 - 0.014 14.9 0.9 0.29 10.7 0.2 2.8 1 1 1 2 2 2 0 NmrA-like family KR PF08659.10 EMD63886.1 - 0.027 14.4 1.5 0.82 9.5 0.2 2.7 2 1 1 3 3 3 0 KR domain adh_short PF00106.25 EMD63886.1 - 0.049 13.1 0.0 0.16 11.4 0.0 1.9 2 1 0 2 2 2 0 short chain dehydrogenase DIOX_N PF14226.6 EMD63887.1 - 7.3e-30 104.1 0.0 1.1e-29 103.6 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EMD63887.1 - 9.2e-20 71.0 0.0 1.5e-19 70.4 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily MFS_1 PF07690.16 EMD63888.1 - 3.3e-44 151.3 43.1 3.3e-44 151.3 43.1 2.0 2 1 0 2 2 2 1 Major Facilitator Superfamily FAD_binding_3 PF01494.19 EMD63888.1 - 1.8e-19 70.2 0.1 6.8e-19 68.3 0.1 2.0 1 1 0 1 1 1 1 FAD binding domain TRI12 PF06609.13 EMD63888.1 - 1.3e-06 27.1 19.2 4.6e-06 25.3 19.1 2.0 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DAO PF01266.24 EMD63888.1 - 0.00016 21.3 0.8 0.00061 19.5 0.4 2.0 1 1 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EMD63888.1 - 0.0013 18.9 0.5 0.0044 17.2 0.1 2.2 2 0 0 2 2 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 EMD63888.1 - 0.0023 17.9 0.0 0.0054 16.7 0.0 1.7 1 1 0 1 1 1 1 FAD-NAD(P)-binding Pyr_redox PF00070.27 EMD63888.1 - 0.0028 18.2 0.1 0.0063 17.0 0.1 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EMD63888.1 - 0.0064 15.8 0.0 0.016 14.5 0.0 1.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase SE PF08491.10 EMD63888.1 - 0.08 12.0 0.0 4.5 6.2 0.0 2.4 2 0 0 2 2 2 0 Squalene epoxidase F420_oxidored PF03807.17 EMD63888.1 - 0.19 12.3 0.4 0.5 11.0 0.4 1.7 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent OATP PF03137.20 EMD63888.1 - 6.2 5.0 14.7 0.0078 14.5 2.7 2.1 2 1 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Transferase PF02458.15 EMD63889.1 - 5.1e-17 61.7 0.0 1.5e-15 56.9 0.0 2.3 2 1 0 2 2 2 2 Transferase family Abhydrolase_1 PF00561.20 EMD63890.1 - 3.7e-19 69.4 0.0 3.2e-15 56.5 0.0 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_4 PF08386.10 EMD63890.1 - 5.5e-18 65.0 0.0 2.3e-17 63.0 0.0 2.0 2 0 0 2 2 2 1 TAP-like protein HemY_N PF07219.13 EMD63891.1 - 0.013 15.7 0.9 0.016 15.4 0.9 1.1 1 0 0 1 1 1 0 HemY protein N-terminus zf-CCHC PF00098.23 EMD63891.1 - 0.3 11.3 3.2 0.48 10.6 3.2 1.3 1 0 0 1 1 1 0 Zinc knuckle DUF1768 PF08719.11 EMD63893.1 - 8.6e-31 107.4 0.0 1.1e-30 107.0 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1768) 2Fe-2S_Ferredox PF11591.8 EMD63893.1 - 0.016 15.1 3.5 0.033 14.0 3.5 1.4 1 0 0 1 1 1 0 Ferredoxin chloroplastic transit peptide DDE_1 PF03184.19 EMD63895.1 - 3.6e-09 36.5 0.1 4e-09 36.4 0.1 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease Fungal_trans_2 PF11951.8 EMD63898.1 - 2.1e-34 119.0 0.1 2.8e-34 118.6 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD63898.1 - 2.9e-08 33.7 11.6 5.7e-08 32.8 11.6 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain His_Phos_2 PF00328.22 EMD63899.1 - 2.5e-25 89.7 0.0 3.3e-25 89.2 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) DUF2613 PF11021.8 EMD63900.1 - 0.092 12.9 3.8 2.8 8.1 0.1 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2613) PTR2 PF00854.21 EMD63902.1 - 4.5e-50 170.6 2.6 9.6e-50 169.5 2.6 1.5 1 1 0 1 1 1 1 POT family MFS_1 PF07690.16 EMD63902.1 - 9.3e-08 31.4 27.0 0.00013 21.0 7.7 3.6 1 1 3 4 4 4 3 Major Facilitator Superfamily DUF3938 PF13074.6 EMD63902.1 - 0.063 13.5 0.8 17 5.8 0.1 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3938) APC_r PF05923.12 EMD63902.1 - 0.13 12.0 0.1 0.31 10.8 0.1 1.6 1 0 0 1 1 1 0 APC repeat DUF2070 PF09843.9 EMD63902.1 - 3 6.0 6.5 0.2 9.9 1.2 1.7 2 0 0 2 2 2 0 Predicted membrane protein (DUF2070) Voltage_CLC PF00654.20 EMD63903.1 - 3.6e-87 292.9 20.8 3.6e-87 292.9 20.8 2.0 2 0 0 2 2 2 2 Voltage gated chloride channel Lipase_GDSL_2 PF13472.6 EMD63905.1 - 4.6e-24 85.8 0.1 1.3e-23 84.4 0.1 1.7 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EMD63905.1 - 5.4e-17 62.4 0.0 6.5e-17 62.2 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase UCH PF00443.29 EMD63906.1 - 8e-65 218.9 0.0 3.4e-64 216.8 0.0 2.0 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.12 EMD63906.1 - 1.6e-12 47.8 0.1 1e-11 45.3 0.0 2.4 2 0 0 2 2 2 1 DUSP domain UCH_1 PF13423.6 EMD63906.1 - 1.2e-07 31.7 0.0 0.13 11.9 0.0 3.4 3 0 0 3 3 3 3 Ubiquitin carboxyl-terminal hydrolase Ubiquitin_3 PF14836.6 EMD63906.1 - 0.038 14.0 0.2 0.1 12.6 0.2 1.7 1 0 0 1 1 1 0 Ubiquitin-like domain DUF4711 PF15829.5 EMD63907.1 - 0.083 12.8 0.9 0.11 12.4 0.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4711) Reprolysin_4 PF13583.6 EMD63907.1 - 0.18 11.4 2.7 0.28 10.8 2.7 1.2 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like DUF3245 PF11595.8 EMD63907.1 - 0.2 12.1 1.5 0.27 11.7 1.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3245) Dicty_REP PF05086.12 EMD63907.1 - 1.5 6.7 6.1 1.8 6.5 6.1 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Clr5 PF14420.6 EMD63908.1 - 4.2e-11 42.9 2.7 8.3e-11 41.9 2.7 1.5 1 0 0 1 1 1 1 Clr5 domain Ank_2 PF12796.7 EMD63908.1 - 1.3e-09 38.5 0.0 1.1e-06 29.1 0.0 4.4 4 2 0 4 4 4 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMD63908.1 - 1.3e-08 35.2 0.0 0.00065 20.2 0.0 4.2 4 0 0 4 4 4 2 Ankyrin repeats (many copies) Ank PF00023.30 EMD63908.1 - 2.8e-05 24.4 0.1 2.2 8.8 0.0 5.0 4 0 0 4 4 4 1 Ankyrin repeat Ank_3 PF13606.6 EMD63908.1 - 0.00034 20.8 0.0 30 5.6 0.0 6.2 7 0 0 7 7 7 0 Ankyrin repeat Ank_5 PF13857.6 EMD63908.1 - 0.023 15.0 0.0 22 5.5 0.0 4.5 3 1 1 4 4 4 0 Ankyrin repeats (many copies) DUF1272 PF06906.11 EMD63908.1 - 0.71 10.0 5.9 1.8 8.7 5.9 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) MFS_1 PF07690.16 EMD63909.1 - 5.6e-30 104.5 42.4 5.3e-27 94.7 22.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Pox_A14 PF05767.12 EMD63909.1 - 0.029 14.5 0.5 12 6.1 0.1 2.8 2 0 0 2 2 2 0 Poxvirus virion envelope protein A14 HlyIII PF03006.20 EMD63910.1 - 1.2e-48 165.7 14.2 1.6e-48 165.4 14.2 1.0 1 0 0 1 1 1 1 Haemolysin-III related DUF962 PF06127.11 EMD63910.1 - 0.015 15.4 1.7 0.015 15.4 1.7 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF962) Bax1-I PF01027.20 EMD63910.1 - 0.069 13.0 9.8 0.22 11.3 1.4 2.3 2 0 0 2 2 2 0 Inhibitor of apoptosis-promoting Bax1 DUF4149 PF13664.6 EMD63910.1 - 0.26 11.7 7.7 3.8 7.9 1.0 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4149) Pkinase PF00069.25 EMD63911.1 - 8.9e-74 248.2 0.2 1.6e-73 247.3 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD63911.1 - 5.2e-38 130.8 0.0 9.1e-38 130.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMD63911.1 - 4.4e-06 26.2 0.0 1e-05 25.0 0.0 1.7 1 1 0 1 1 1 1 Kinase-like TFIIA PF03153.13 EMD63911.1 - 0.0092 16.0 23.9 0.013 15.5 23.9 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Med3 PF11593.8 EMD63911.1 - 4 6.5 31.7 7.8 5.6 31.7 1.4 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Menin PF05053.13 EMD63911.1 - 9.2 4.5 13.1 15 3.8 13.1 1.3 1 0 0 1 1 1 0 Menin SPX PF03105.19 EMD63911.1 - 9.5 6.0 21.9 17 5.2 21.9 1.3 1 0 0 1 1 1 0 SPX domain COX8 PF02285.15 EMD63912.1 - 0.24 11.3 1.9 0.5 10.3 1.9 1.5 1 0 0 1 1 1 0 Cytochrome oxidase c subunit VIII PRP38 PF03371.15 EMD63913.1 - 5.7e-63 211.9 0.0 7.1e-63 211.6 0.0 1.1 1 0 0 1 1 1 1 PRP38 family PRP38_assoc PF12871.7 EMD63913.1 - 4.8 7.9 59.3 0.21 12.2 47.4 2.3 2 0 0 2 2 2 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term Amidase PF01425.21 EMD63914.1 - 3.4e-58 197.7 0.5 1.4e-52 179.2 0.4 2.2 2 0 0 2 2 2 2 Amidase K_channel_TID PF07941.11 EMD63915.1 - 0.14 12.7 5.4 0.17 12.3 5.4 1.1 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain PEX11 PF05648.14 EMD63916.1 - 3.9e-10 39.6 0.0 7.1e-10 38.7 0.0 1.4 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) DUF1899 PF08953.11 EMD63917.1 - 7.9e-36 121.8 0.1 1.7e-35 120.7 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) WD40_4 PF16300.5 EMD63917.1 - 2.4e-20 72.2 0.1 5.1e-20 71.1 0.1 1.6 1 0 0 1 1 1 1 Type of WD40 repeat WD40 PF00400.32 EMD63917.1 - 2.1e-16 60.0 8.1 6.3e-06 26.8 0.2 4.9 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD63917.1 - 7.5e-06 26.2 0.0 0.027 14.8 0.0 4.0 2 1 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EMD63917.1 - 0.01 14.5 0.4 0.25 10.0 0.2 2.3 1 1 1 2 2 2 0 Nucleoporin Nup120/160 SlyX PF04102.12 EMD63917.1 - 0.014 16.0 3.1 0.031 14.9 3.1 1.6 1 0 0 1 1 1 0 SlyX Ge1_WD40 PF16529.5 EMD63917.1 - 0.16 10.9 0.0 6.4 5.6 0.0 2.3 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein BLOC1_2 PF10046.9 EMD63917.1 - 0.24 11.7 2.4 0.41 11.0 2.4 1.3 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 ATG16 PF08614.11 EMD63917.1 - 1.4 9.1 13.7 0.095 12.9 8.3 1.6 1 1 0 2 2 2 0 Autophagy protein 16 (ATG16) FAM76 PF16046.5 EMD63917.1 - 2.4 7.4 3.7 3.8 6.8 3.7 1.3 1 0 0 1 1 1 0 FAM76 protein PKcGMP_CC PF16808.5 EMD63917.1 - 7 6.6 7.2 3.5 7.5 4.5 1.9 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Kinesin PF00225.23 EMD63918.1 - 6.1e-101 337.7 0.2 6.1e-101 337.7 0.2 2.2 2 1 1 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 EMD63918.1 - 9.5e-59 197.6 2.4 1.2e-57 194.0 0.0 2.8 2 0 0 2 2 2 1 Microtubule binding AAA_16 PF13191.6 EMD63918.1 - 0.018 15.4 0.0 0.018 15.4 0.0 3.3 2 1 0 3 3 3 0 AAA ATPase domain BLOC1_2 PF10046.9 EMD63918.1 - 1.1 9.7 19.4 0.18 12.1 0.9 4.8 2 2 2 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 AAA_22 PF13401.6 EMD63918.1 - 2.5 8.4 7.5 0.52 10.6 0.3 3.3 2 2 1 3 3 3 0 AAA domain LRR_4 PF12799.7 EMD63919.1 - 2.7e-35 119.8 18.1 4e-08 33.4 1.1 6.4 5 1 2 7 7 7 7 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EMD63919.1 - 1.3e-16 60.1 24.6 9.3e-07 28.5 1.5 5.8 2 2 4 6 6 6 5 Leucine rich repeat LRR_9 PF14580.6 EMD63919.1 - 3.1e-12 46.3 11.6 4.1e-06 26.4 0.8 4.0 1 1 3 4 4 4 3 Leucine-rich repeat LRR_1 PF00560.33 EMD63919.1 - 0.0062 16.9 16.7 21 6.1 2.4 8.3 7 2 0 7 7 7 1 Leucine Rich Repeat LRR_6 PF13516.6 EMD63919.1 - 0.0078 16.2 16.8 0.8 9.9 0.1 7.1 8 0 0 8 8 8 2 Leucine Rich repeat DUF4203 PF13886.6 EMD63920.1 - 1.2 8.8 6.3 2.1 7.9 6.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4203) NIF PF03031.18 EMD63921.1 - 3.1e-54 183.0 0.1 4.1e-54 182.6 0.1 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase p450 PF00067.22 EMD63923.1 - 2.5e-61 207.9 0.0 3.2e-61 207.5 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 DUF3270 PF11674.8 EMD63924.1 - 4.7 7.5 5.4 0.79 9.9 0.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3270) CTP_synth_N PF06418.14 EMD63926.1 - 3.7e-126 419.8 0.6 5.5e-126 419.3 0.6 1.3 1 0 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.28 EMD63926.1 - 4.2e-55 186.5 0.0 7e-55 185.8 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 EMD63926.1 - 1.5e-05 24.9 0.4 0.00018 21.3 0.4 2.4 1 1 0 1 1 1 1 Peptidase C26 CbiA PF01656.23 EMD63926.1 - 0.1 12.6 0.0 0.19 11.8 0.0 1.4 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain Velvet PF11754.8 EMD63927.1 - 1.1e-60 205.7 3.2 6.3e-37 127.9 0.0 2.9 2 1 1 3 3 3 2 Velvet factor Bin3 PF06859.12 EMD63928.1 - 3.2e-25 88.9 0.0 4.5e-25 88.4 0.0 1.3 1 0 0 1 1 1 1 Bicoid-interacting protein 3 (Bin3) Methyltransf_23 PF13489.6 EMD63928.1 - 8.7e-11 41.9 0.0 1.1e-10 41.6 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMD63928.1 - 2.5e-08 34.5 0.0 3.6e-07 30.8 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMD63928.1 - 2.6e-08 33.8 0.0 0.00067 19.5 0.0 2.7 2 1 1 3 3 3 2 Methyltransferase domain Methyltransf_25 PF13649.6 EMD63928.1 - 4.7e-08 33.6 0.0 0.00077 20.1 0.0 3.0 3 0 0 3 3 3 2 Methyltransferase domain Methyltransf_11 PF08241.12 EMD63928.1 - 1.2e-07 32.2 0.0 0.025 15.2 0.0 2.5 3 0 0 3 3 3 2 Methyltransferase domain Methyltransf_PK PF05891.12 EMD63928.1 - 0.00013 21.5 0.0 0.00084 18.9 0.0 2.1 2 1 0 2 2 2 1 AdoMet dependent proline di-methyltransferase MTS PF05175.14 EMD63928.1 - 0.0074 15.9 0.0 0.055 13.0 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_18 PF12847.7 EMD63928.1 - 0.13 12.2 0.0 0.2 11.6 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain PrmA PF06325.13 EMD63928.1 - 0.22 10.9 0.1 0.36 10.2 0.1 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) DUF1349 PF07081.11 EMD63929.1 - 2.5e-25 89.2 0.1 4e-25 88.6 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1349) SE PF08491.10 EMD63930.1 - 3.7e-99 331.3 0.0 4.8e-99 330.9 0.0 1.1 1 0 0 1 1 1 1 Squalene epoxidase FAD_binding_3 PF01494.19 EMD63930.1 - 5.2e-11 42.4 0.0 8.4e-11 41.7 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 EMD63930.1 - 3e-08 33.6 0.3 5.5e-05 22.9 0.3 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase GIDA PF01134.22 EMD63930.1 - 2.8e-06 26.7 1.0 8.5e-06 25.1 1.0 1.6 1 1 0 1 1 1 1 Glucose inhibited division protein A FAD_oxidored PF12831.7 EMD63930.1 - 4.4e-06 26.3 0.0 6.8e-06 25.7 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EMD63930.1 - 5.5e-05 22.4 3.7 0.00033 19.9 1.9 2.1 1 1 1 2 2 2 1 FAD binding domain Thi4 PF01946.17 EMD63930.1 - 8.9e-05 21.8 0.0 0.0035 16.6 0.0 2.1 2 0 0 2 2 2 1 Thi4 family NAD_binding_8 PF13450.6 EMD63930.1 - 0.0016 18.6 0.8 0.0033 17.6 0.8 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EMD63930.1 - 0.0086 15.3 0.4 0.016 14.5 0.2 1.5 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EMD63930.1 - 0.011 14.4 0.4 0.016 13.9 0.4 1.2 1 0 0 1 1 1 0 HI0933-like protein Trp_halogenase PF04820.14 EMD63930.1 - 0.015 14.2 1.5 0.42 9.4 0.3 2.2 1 1 0 2 2 2 0 Tryptophan halogenase Pyr_redox PF00070.27 EMD63930.1 - 0.088 13.4 0.2 0.088 13.4 0.2 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.16 EMD63930.1 - 0.17 11.5 0.1 0.33 10.6 0.1 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Lycopene_cycl PF05834.12 EMD63930.1 - 0.21 10.6 1.5 0.49 9.4 0.4 2.1 3 0 0 3 3 3 0 Lycopene cyclase protein OAD_gamma PF04277.13 EMD63931.1 - 0.0075 16.8 0.0 0.017 15.7 0.0 1.6 1 0 0 1 1 1 1 Oxaloacetate decarboxylase, gamma chain Sid-5 PF17204.3 EMD63931.1 - 0.25 11.5 0.2 0.56 10.4 0.0 1.6 2 0 0 2 2 2 0 Sid-5 family NUDIX PF00293.28 EMD63933.1 - 2.5e-14 53.4 0.0 3.7e-14 52.9 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain Ras PF00071.22 EMD63934.1 - 1e-19 70.7 0.1 2.1e-19 69.7 0.1 1.5 1 1 0 1 1 1 1 Ras family Roc PF08477.13 EMD63934.1 - 6.8e-05 23.1 0.0 0.00023 21.4 0.0 2.0 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.6 EMD63934.1 - 0.042 14.2 0.0 0.044 14.2 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain MMR_HSR1 PF01926.23 EMD63934.1 - 0.055 13.5 0.0 0.093 12.8 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EMD63934.1 - 0.063 13.2 0.3 1.4 8.8 0.1 2.1 2 0 0 2 2 2 0 RsgA GTPase dCMP_cyt_deam_1 PF00383.23 EMD63934.1 - 0.079 12.8 0.1 0.13 12.2 0.1 1.3 1 0 0 1 1 1 0 Cytidine and deoxycytidylate deaminase zinc-binding region DUF2024 PF09630.10 EMD63934.1 - 0.19 11.6 0.4 20 5.1 0.1 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF2024) Metallophos PF00149.28 EMD63936.1 - 9.1e-11 42.6 0.0 1.4e-10 42.0 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EMD63936.1 - 3.5e-05 24.1 0.4 8.7e-05 22.8 0.0 1.7 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase superfamily domain Peroxidase_2 PF01328.17 EMD63937.1 - 2.7e-46 158.5 0.0 3.5e-46 158.1 0.0 1.1 1 0 0 1 1 1 1 Peroxidase, family 2 CFEM PF05730.11 EMD63938.1 - 2.6e-11 43.5 11.6 4.2e-11 42.8 11.6 1.3 1 0 0 1 1 1 1 CFEM domain COX14 PF14880.6 EMD63938.1 - 0.23 11.4 9.0 5.6 6.9 0.6 3.6 4 0 0 4 4 4 0 Cytochrome oxidase c assembly GMC_oxred_C PF05199.13 EMD63939.1 - 4.4e-29 101.9 0.0 7.9e-29 101.0 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_N PF00732.19 EMD63939.1 - 8.7e-25 87.7 0.0 6.6e-19 68.4 0.0 3.6 3 1 0 3 3 3 2 GMC oxidoreductase Pyr_redox_2 PF07992.14 EMD63939.1 - 4.8e-06 26.0 0.0 0.00018 20.8 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EMD63939.1 - 1.4e-05 24.9 0.3 0.0048 16.5 0.0 3.2 3 1 0 3 3 3 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EMD63939.1 - 6.1e-05 23.2 0.0 0.00015 22.0 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EMD63939.1 - 0.00075 18.7 0.0 0.0072 15.4 0.0 2.0 2 0 0 2 2 2 1 FAD binding domain Lycopene_cycl PF05834.12 EMD63939.1 - 0.0024 17.0 0.0 0.0037 16.4 0.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_3 PF13738.6 EMD63939.1 - 0.0035 16.6 0.1 2.7 7.2 0.0 2.5 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.16 EMD63939.1 - 0.011 15.3 0.1 0.023 14.3 0.1 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA ThiF PF00899.21 EMD63939.1 - 0.026 13.9 0.0 0.051 12.9 0.0 1.3 1 0 0 1 1 1 0 ThiF family Pkinase PF00069.25 EMD63940.1 - 6.4e-09 35.6 0.0 1.2e-06 28.1 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EMD63940.1 - 2.6e-05 23.6 0.0 0.012 14.9 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase DUF2439 PF10382.9 EMD63941.1 - 9.9e-27 93.1 0.1 1.9e-26 92.2 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2439) SH3_1 PF00018.28 EMD63942.1 - 5.9e-13 48.2 0.0 1.1e-12 47.4 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EMD63942.1 - 3.6e-12 46.0 0.0 6.3e-12 45.2 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain BAR PF03114.18 EMD63942.1 - 3.2e-10 40.1 3.3 4.4e-10 39.6 3.3 1.1 1 0 0 1 1 1 1 BAR domain SH3_2 PF07653.17 EMD63942.1 - 5.7e-10 38.7 0.0 1e-09 37.9 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain ADIP PF11559.8 EMD63942.1 - 0.058 13.5 3.1 0.12 12.4 3.1 1.5 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding DUF1380 PF07128.12 EMD63942.1 - 0.059 13.5 0.0 0.12 12.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1380) DUF1828 PF08861.10 EMD63942.1 - 0.091 13.1 0.1 0.33 11.3 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function DUF1828 THOC7 PF05615.13 EMD63942.1 - 0.33 11.2 9.0 3.7 7.8 3.9 2.2 2 0 0 2 2 2 0 Tho complex subunit 7 GAS PF13851.6 EMD63942.1 - 2.1 7.6 9.8 0.72 9.2 5.8 1.9 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding DHHC PF01529.20 EMD63943.1 - 0.68 10.0 6.0 1.2 9.2 6.0 1.4 1 0 0 1 1 1 0 DHHC palmitoyltransferase LapA_dom PF06305.11 EMD63945.1 - 0.00065 19.5 2.7 0.39 10.6 0.0 2.5 3 0 0 3 3 3 2 Lipopolysaccharide assembly protein A domain DUF2721 PF11026.8 EMD63945.1 - 0.16 11.8 7.7 2 8.3 0.1 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF2721) DUF5056 PF16479.5 EMD63945.1 - 0.21 11.8 0.7 4.1 7.7 0.1 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF5056) CcmD PF04995.14 EMD63945.1 - 7 6.8 8.7 5.2 7.2 0.2 3.2 3 0 0 3 3 3 0 Heme exporter protein D (CcmD) MFS_1 PF07690.16 EMD63948.1 - 1.7e-15 56.8 31.3 1.7e-15 56.8 31.3 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily Nse4_C PF08743.10 EMD63949.1 - 9.8e-34 115.5 0.0 2.8e-33 114.0 0.0 1.8 1 0 0 1 1 1 1 Nse4 C-terminal Nse4-Nse3_bdg PF15412.6 EMD63949.1 - 6.1e-11 42.2 0.4 6.1e-11 42.2 0.4 2.2 2 0 0 2 2 2 1 Binding domain of Nse4/EID3 to Nse3-MAGE PI3Ka PF00613.20 EMD63950.1 - 1.2e-55 187.8 0.1 1.9e-55 187.1 0.1 1.2 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.27 EMD63950.1 - 6.1e-41 140.9 0.0 9.8e-38 130.4 0.0 2.4 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3K_C2 PF00792.24 EMD63950.1 - 2.2e-29 102.2 0.0 3.5e-29 101.5 0.0 1.3 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 Abhydrolase_3 PF07859.13 EMD63951.1 - 8.8e-14 51.9 0.0 1.3e-13 51.4 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Chlorophyllase2 PF12740.7 EMD63951.1 - 2.5e-07 29.9 0.0 3.3e-07 29.5 0.0 1.1 1 0 0 1 1 1 1 Chlorophyllase enzyme Peptidase_S9 PF00326.21 EMD63951.1 - 8.5e-07 28.7 0.0 0.0003 20.3 0.0 2.3 1 1 1 2 2 2 2 Prolyl oligopeptidase family Chlorophyllase PF07224.11 EMD63951.1 - 0.00013 21.1 0.0 0.00018 20.6 0.0 1.1 1 0 0 1 1 1 1 Chlorophyllase AXE1 PF05448.12 EMD63951.1 - 0.00015 20.6 0.0 0.023 13.4 0.0 2.1 2 0 0 2 2 2 2 Acetyl xylan esterase (AXE1) COesterase PF00135.28 EMD63951.1 - 0.0011 17.9 0.0 0.0056 15.6 0.1 1.8 2 0 0 2 2 2 1 Carboxylesterase family Abhydrolase_2 PF02230.16 EMD63951.1 - 0.0012 18.7 0.0 1.5 8.6 0.0 2.2 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.8 EMD63951.1 - 0.0021 17.4 0.0 0.029 13.7 0.0 2.3 1 1 0 1 1 1 1 Serine aminopeptidase, S33 LIDHydrolase PF10230.9 EMD63951.1 - 0.017 14.6 0.0 0.036 13.6 0.0 1.5 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase Say1_Mug180 PF10340.9 EMD63951.1 - 0.063 12.1 0.0 3.5 6.4 0.0 2.0 2 0 0 2 2 2 0 Steryl acetyl hydrolase Esterase PF00756.20 EMD63951.1 - 0.19 11.3 0.0 0.55 9.8 0.0 1.7 1 1 0 1 1 1 0 Putative esterase Esterase_phd PF10503.9 EMD63951.1 - 0.24 10.9 0.0 20 4.6 0.0 2.6 3 0 0 3 3 3 0 Esterase PHB depolymerase BMC PF00936.19 EMD63952.1 - 0.022 14.8 0.1 0.032 14.2 0.1 1.3 1 0 0 1 1 1 0 BMC domain THOC7 PF05615.13 EMD63952.1 - 0.055 13.8 4.7 0.07 13.4 4.7 1.1 1 0 0 1 1 1 0 Tho complex subunit 7 HemY_N PF07219.13 EMD63952.1 - 0.62 10.3 6.4 0.81 9.9 6.2 1.4 1 1 0 1 1 1 0 HemY protein N-terminus DUF4520 PF15016.6 EMD63958.1 - 0.039 14.0 0.3 0.08 13.0 0.1 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4520) Glyco_hydro_32N PF00251.20 EMD63962.1 - 1.9e-78 264.2 0.7 2.4e-78 263.8 0.7 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 N-terminal domain Glyco_hydro_32C PF08244.12 EMD63962.1 - 2.5e-09 37.3 0.0 6.2e-09 36.0 0.0 1.6 1 1 0 1 1 1 1 Glycosyl hydrolases family 32 C terminal Aldo_ket_red PF00248.21 EMD63963.1 - 3.9e-32 111.6 0.0 4.5e-32 111.4 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family DUF1574 PF07611.11 EMD63964.1 - 0.035 13.5 0.0 0.046 13.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1574) 4HBT PF03061.22 EMD63965.1 - 1.2e-07 32.0 0.3 1.4e-07 31.8 0.3 1.2 1 0 0 1 1 1 1 Thioesterase superfamily Fungal_trans PF04082.18 EMD63966.1 - 2.1e-07 30.2 0.1 3.6e-07 29.5 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain HlyIII PF03006.20 EMD63966.1 - 0.14 11.8 0.0 0.26 11.0 0.0 1.3 1 0 0 1 1 1 0 Haemolysin-III related AtuA PF07287.11 EMD63967.1 - 6.6e-72 242.1 0.2 9.6e-47 159.4 0.1 3.1 1 1 2 3 3 3 3 Acyclic terpene utilisation family protein AtuA AMP-binding PF00501.28 EMD63968.1 - 4.1e-58 197.0 0.0 2e-57 194.7 0.0 1.8 1 1 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EMD63968.1 - 1.9e-14 54.4 0.4 4.3e-14 53.2 0.4 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Histone PF00125.24 EMD63971.1 - 1e-07 32.4 0.4 1.1e-07 32.2 0.4 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 RNase_E_G PF10150.9 EMD63972.1 - 0.3 10.5 5.9 0.63 9.4 4.3 2.2 1 1 1 2 2 2 0 Ribonuclease E/G family Dimer_Tnp_hAT PF05699.14 EMD63973.1 - 6.3e-14 51.5 0.0 6.8e-14 51.4 0.0 1.0 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Glyco_transf_25 PF01755.17 EMD63974.1 - 1.2e-12 48.1 0.0 5.5e-12 46.0 0.0 1.9 1 1 0 1 1 1 1 Glycosyltransferase family 25 (LPS biosynthesis protein) DDE_1 PF03184.19 EMD63976.1 - 3.3e-07 30.1 0.0 8.1e-07 28.9 0.0 1.7 2 0 0 2 2 2 1 DDE superfamily endonuclease RBR PF17208.3 EMD63976.1 - 0.0018 18.9 1.7 0.0073 17.0 1.7 2.0 1 0 0 1 1 1 1 RNA binding Region LZ_Tnp_IS66 PF13007.7 EMD63976.1 - 0.0079 16.9 3.8 0.033 15.0 3.8 2.1 1 1 0 1 1 1 1 Transposase C of IS166 homeodomain DUF4507 PF14964.6 EMD63976.1 - 0.046 12.6 4.4 0.066 12.1 4.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4507) LprI PF07007.12 EMD63976.1 - 0.22 12.2 2.7 0.43 11.3 2.6 1.5 1 1 0 1 1 1 0 Lysozyme inhibitor LprI F-box-like PF12937.7 EMD63982.1 - 0.0012 18.7 0.1 0.0023 17.8 0.1 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EMD63982.1 - 0.015 15.2 0.1 0.031 14.2 0.1 1.6 1 0 0 1 1 1 0 F-box domain RdRP_4 PF02123.16 EMD63983.1 - 0.023 13.6 0.2 0.025 13.5 0.2 1.1 1 0 0 1 1 1 0 Viral RNA-directed RNA-polymerase Syncollin PF15138.6 EMD63983.1 - 0.053 13.7 0.0 0.06 13.5 0.0 1.2 1 0 0 1 1 1 0 Syncollin Glyco_hydro_32N PF00251.20 EMD63984.1 - 4.1e-70 236.8 6.6 4.9e-70 236.5 6.6 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 N-terminal domain Glyco_hydro_32C PF08244.12 EMD63984.1 - 6.5e-16 58.7 0.0 1.3e-15 57.8 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 C terminal Crystall_3 PF08964.10 EMD63985.1 - 0.0012 18.9 0.5 0.0025 17.9 0.5 1.5 1 1 0 1 1 1 1 Beta/Gamma crystallin LSPR PF06049.12 EMD63985.1 - 2.4 8.3 3.9 6.3 7.1 0.6 2.6 2 0 0 2 2 2 0 Coagulation Factor V LSPD Repeat AAA_12 PF13087.6 EMD63986.1 - 5e-13 49.1 0.1 8.6e-13 48.4 0.1 1.4 1 0 0 1 1 1 1 AAA domain NRDD PF13597.6 EMD63986.1 - 0.063 12.0 0.2 0.1 11.4 0.2 1.2 1 0 0 1 1 1 0 Anaerobic ribonucleoside-triphosphate reductase KR PF08659.10 EMD63988.1 - 7.7e-26 91.1 0.0 9.2e-26 90.8 0.0 1.0 1 0 0 1 1 1 1 KR domain adh_short PF00106.25 EMD63988.1 - 4.3e-05 23.1 0.0 8.4e-05 22.1 0.0 1.4 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD63988.1 - 0.00025 20.7 0.0 0.00036 20.2 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase GFA PF04828.14 EMD63990.1 - 0.0013 19.0 1.9 0.0013 19.0 1.9 2.1 2 1 0 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme SIR2 PF02146.17 EMD63990.1 - 0.096 12.6 0.4 0.14 12.0 0.4 1.2 1 0 0 1 1 1 0 Sir2 family zf-CSL PF05207.13 EMD63990.1 - 0.48 10.2 6.6 0.21 11.4 4.2 1.6 2 0 0 2 2 2 0 CSL zinc finger DUF3632 PF12311.8 EMD63991.1 - 2.9e-19 70.2 0.0 4.5e-19 69.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3632) Cupin_2 PF07883.11 EMD63992.1 - 2.5e-26 91.2 1.6 3.6e-17 61.8 0.2 2.4 2 0 0 2 2 2 2 Cupin domain AraC_binding PF02311.19 EMD63992.1 - 5.1e-06 26.4 0.3 0.00085 19.2 0.1 2.3 2 0 0 2 2 2 2 AraC-like ligand binding domain Cupin_3 PF05899.12 EMD63992.1 - 5.1e-05 22.9 0.1 0.37 10.5 0.1 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF861) DMSP_lyase PF16867.5 EMD63992.1 - 0.0064 16.1 0.1 0.014 15.0 0.1 1.6 1 0 0 1 1 1 1 Dimethlysulfonioproprionate lyase ARD PF03079.14 EMD63992.1 - 0.016 15.4 0.1 0.68 10.1 0.0 2.3 2 0 0 2 2 2 0 ARD/ARD' family CENP-C_C PF11699.8 EMD63992.1 - 0.052 13.8 0.0 0.16 12.2 0.0 1.7 2 0 0 2 2 2 0 Mif2/CENP-C like EutQ PF06249.12 EMD63992.1 - 0.11 12.2 0.0 18 5.0 0.0 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation protein EutQ FAA_hydrolase PF01557.18 EMD63993.1 - 2.9e-61 206.9 0.0 3.4e-61 206.7 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family MAGUK_N_PEST PF10608.9 EMD63993.1 - 0.15 12.5 0.0 0.35 11.3 0.0 1.6 1 1 0 1 1 1 0 Polyubiquitination (PEST) N-terminal domain of MAGUK TPP_enzyme_N PF02776.18 EMD63994.1 - 4.9e-41 140.2 0.0 1.1e-40 139.1 0.0 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 EMD63994.1 - 2.5e-14 53.3 0.0 8.1e-14 51.7 0.0 1.8 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 EMD63994.1 - 8e-09 35.3 0.0 7.8e-08 32.1 0.0 2.2 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain UbiD PF01977.16 EMD63995.1 - 3.5e-115 385.1 0.0 4.3e-115 384.8 0.0 1.1 1 0 0 1 1 1 1 3-octaprenyl-4-hydroxybenzoate carboxy-lyase Flavoprotein PF02441.19 EMD63996.1 - 4e-23 81.9 0.0 4.8e-23 81.6 0.0 1.1 1 0 0 1 1 1 1 Flavoprotein SnoaL PF07366.12 EMD63997.1 - 9.2e-06 25.5 0.0 1.9e-05 24.4 0.0 1.5 1 1 0 1 1 1 1 SnoaL-like polyketide cyclase SnoaL_2 PF12680.7 EMD63997.1 - 0.0016 19.0 0.0 0.0031 18.1 0.0 1.5 1 0 0 1 1 1 1 SnoaL-like domain Fungal_trans PF04082.18 EMD63998.1 - 1.9e-10 40.2 0.2 3.4e-10 39.4 0.2 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD63998.1 - 6e-08 32.7 11.3 1.3e-07 31.6 11.3 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FAD_binding_4 PF01565.23 EMD63999.1 - 9e-22 77.3 0.0 1.6e-21 76.5 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain CYYR1 PF10873.8 EMD63999.1 - 0.18 12.3 0.0 0.4 11.1 0.0 1.6 1 0 0 1 1 1 0 Cysteine and tyrosine-rich protein 1 Aldedh PF00171.22 EMD64000.1 - 1.4e-149 498.6 0.0 1.6e-149 498.4 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 EMD64000.1 - 0.034 13.6 0.0 0.08 12.4 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1487) AA_permease_2 PF13520.6 EMD64001.1 - 1.6e-59 201.9 51.5 2e-59 201.5 51.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EMD64001.1 - 2.7e-27 95.5 42.6 3.5e-27 95.1 42.6 1.1 1 0 0 1 1 1 1 Amino acid permease Aldedh PF00171.22 EMD64002.1 - 7.5e-132 440.1 0.0 9.1e-132 439.8 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family FAD_binding_3 PF01494.19 EMD64003.1 - 6e-18 65.2 0.0 1.9e-17 63.6 0.0 1.7 2 0 0 2 2 2 1 FAD binding domain NAD_binding_8 PF13450.6 EMD64003.1 - 5.5e-06 26.5 0.5 1.4e-05 25.2 0.5 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EMD64003.1 - 0.00054 19.7 6.1 0.0007 19.3 5.4 1.6 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_oxidored PF12831.7 EMD64003.1 - 0.0054 16.1 0.6 0.0078 15.6 0.1 1.6 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EMD64003.1 - 0.0074 15.6 2.7 0.016 14.4 2.7 1.7 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Rossmann-like PF10727.9 EMD64003.1 - 0.032 14.1 0.3 0.07 13.0 0.3 1.6 1 0 0 1 1 1 0 Rossmann-like domain FAD_binding_2 PF00890.24 EMD64003.1 - 0.15 11.1 3.8 0.3 10.1 2.7 1.9 1 1 1 2 2 2 0 FAD binding domain Pyr_redox PF00070.27 EMD64003.1 - 0.21 12.2 0.2 0.21 12.2 0.2 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase adh_short_C2 PF13561.6 EMD64004.1 - 8.2e-60 202.3 0.3 9.7e-60 202.0 0.3 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EMD64004.1 - 7.2e-50 169.2 0.4 8.7e-50 168.9 0.4 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EMD64004.1 - 3.2e-16 59.8 0.8 5e-16 59.1 0.8 1.2 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 EMD64004.1 - 0.0045 16.4 0.1 0.0066 15.9 0.1 1.1 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) Epimerase PF01370.21 EMD64004.1 - 0.013 15.0 0.1 0.023 14.1 0.1 1.6 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family ADH_zinc_N PF00107.26 EMD64004.1 - 0.026 14.5 0.3 0.075 13.0 0.3 2.0 1 1 0 1 1 1 0 Zinc-binding dehydrogenase TrkA_N PF02254.18 EMD64004.1 - 0.037 14.3 0.0 0.075 13.3 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain DUF43 PF01861.16 EMD64004.1 - 0.046 12.9 0.0 0.065 12.5 0.0 1.2 1 0 0 1 1 1 0 Branched-chain polyamine synthase A C-terminal domain Methyltransf_25 PF13649.6 EMD64004.1 - 0.051 14.3 0.0 0.11 13.2 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain K_oxygenase PF13434.6 EMD64005.1 - 4.2e-17 62.3 0.0 6.8e-15 55.1 0.0 2.7 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.6 EMD64005.1 - 1.4e-13 50.8 0.0 1.5e-11 44.1 0.0 2.3 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EMD64005.1 - 1.4e-12 47.5 0.0 1.4e-09 37.6 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 EMD64005.1 - 8.3e-11 41.0 0.0 3.2e-09 35.8 0.0 2.5 3 0 0 3 3 3 1 Flavin-binding monooxygenase-like NAD_binding_9 PF13454.6 EMD64005.1 - 1.5e-06 28.3 1.3 0.018 15.0 0.1 3.8 3 1 0 3 3 3 1 FAD-NAD(P)-binding Thi4 PF01946.17 EMD64005.1 - 1.7e-06 27.5 1.2 7.7e-05 22.0 0.1 2.4 2 0 0 2 2 2 1 Thi4 family NAD_binding_8 PF13450.6 EMD64005.1 - 4.8e-06 26.7 0.7 0.00021 21.5 0.0 2.7 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EMD64005.1 - 4.1e-05 23.3 4.4 0.1 12.1 0.2 3.4 3 1 0 4 4 4 2 FAD dependent oxidoreductase Pyr_redox PF00070.27 EMD64005.1 - 0.00015 22.3 1.5 0.29 11.7 0.1 3.3 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EMD64005.1 - 0.0041 15.9 0.9 2 7.1 0.0 3.3 4 0 0 4 4 4 2 HI0933-like protein FAD_binding_2 PF00890.24 EMD64005.1 - 0.0047 16.0 1.3 0.14 11.2 0.0 2.8 3 0 0 3 3 3 1 FAD binding domain Lycopene_cycl PF05834.12 EMD64005.1 - 0.013 14.6 0.2 0.44 9.5 0.0 2.9 3 0 0 3 3 3 0 Lycopene cyclase protein GIDA PF01134.22 EMD64005.1 - 0.35 9.9 2.1 25 3.8 0.0 3.2 3 1 0 3 3 3 0 Glucose inhibited division protein A Trp_DMAT PF11991.8 EMD64006.1 - 6.3e-39 134.4 0.0 1.1e-38 133.6 0.0 1.4 1 0 0 1 1 1 1 Tryptophan dimethylallyltransferase Transpeptidase PF00905.22 EMD64006.1 - 0.21 10.8 0.0 0.3 10.3 0.0 1.2 1 0 0 1 1 1 0 Penicillin binding protein transpeptidase domain AflR PF08493.10 EMD64008.1 - 1.3e-17 64.2 11.4 4.2e-17 62.6 11.4 1.8 1 1 0 1 1 1 1 Aflatoxin regulatory protein Zn_clus PF00172.18 EMD64008.1 - 7.1e-08 32.4 12.4 1.5e-07 31.4 12.4 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF1772 PF08592.11 EMD64009.1 - 5.7e-31 107.6 4.2 5.9e-31 107.6 3.3 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF1772) EthD PF07110.11 EMD64009.1 - 1e-13 52.2 0.1 1.6e-13 51.6 0.1 1.3 1 0 0 1 1 1 1 EthD domain EIID-AGA PF03613.14 EMD64009.1 - 0.00078 18.7 0.5 0.0013 18.0 0.5 1.3 1 0 0 1 1 1 1 PTS system mannose/fructose/sorbose family IID component Glucos_trans_II PF14264.6 EMD64009.1 - 0.0035 16.8 1.2 0.0058 16.0 1.2 1.3 1 0 0 1 1 1 1 Glucosyl transferase GtrII DUF2569 PF10754.9 EMD64009.1 - 0.1 13.0 2.6 0.16 12.4 1.9 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2569) adh_short PF00106.25 EMD64010.1 - 2.4e-20 72.8 0.0 2.4e-18 66.3 0.2 2.3 2 1 1 3 3 3 2 short chain dehydrogenase adh_short_C2 PF13561.6 EMD64010.1 - 3.6e-11 43.1 0.1 1.6e-10 40.9 0.2 1.9 1 1 1 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD64010.1 - 1.2e-07 31.8 0.1 2.2e-07 31.0 0.1 1.3 1 0 0 1 1 1 1 KR domain TMEM144 PF07857.12 EMD64010.1 - 0.12 11.4 0.1 0.4 9.6 0.0 1.7 2 0 0 2 2 2 0 Transmembrane family, TMEM144 of transporters Peptidase_C37 PF05416.12 EMD64010.1 - 0.12 10.9 0.0 0.18 10.3 0.0 1.3 1 0 0 1 1 1 0 Southampton virus-type processing peptidase LRR_8 PF13855.6 EMD64011.1 - 7.5e-14 51.2 7.8 3.8e-07 29.8 0.2 4.3 1 1 3 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 EMD64011.1 - 6.9e-09 35.8 12.0 0.00047 20.5 0.1 5.5 3 2 2 5 5 5 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EMD64011.1 - 3.2e-05 23.9 8.9 32 5.6 0.0 7.1 7 0 0 7 7 7 2 Leucine Rich Repeat LRRNT_2 PF08263.12 EMD64011.1 - 0.00039 20.7 0.2 0.00084 19.6 0.2 1.6 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain LRR_9 PF14580.6 EMD64011.1 - 0.19 11.2 0.1 2.4 7.7 0.0 2.1 1 1 1 3 3 3 0 Leucine-rich repeat p450 PF00067.22 EMD64012.1 - 7.2e-23 81.1 0.1 7.6e-23 81.0 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 TPR_12 PF13424.6 EMD64013.1 - 9.8e-69 227.6 26.7 3.6e-19 68.8 0.0 5.9 1 1 5 6 6 6 6 Tetratricopeptide repeat TPR_10 PF13374.6 EMD64013.1 - 6.1e-63 207.1 5.8 1.2e-14 53.6 0.0 7.1 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_7 PF13176.6 EMD64013.1 - 1.1e-16 59.5 4.8 0.0058 16.6 0.0 6.6 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_1 PF00515.28 EMD64013.1 - 3.8e-13 48.7 12.3 0.13 12.1 0.0 7.4 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_4 PF07721.14 EMD64013.1 - 8.2e-12 44.6 0.1 0.19 12.5 0.0 6.0 6 0 0 6 6 4 3 Tetratricopeptide repeat HET PF06985.11 EMD64013.1 - 1.3e-10 41.8 5.2 1.1e-07 32.3 0.1 2.6 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) TPR_16 PF13432.6 EMD64013.1 - 2.1e-09 37.9 1.3 0.099 13.3 0.1 5.8 5 1 2 7 7 5 3 Tetratricopeptide repeat NB-ARC PF00931.22 EMD64013.1 - 6.4e-09 35.4 0.0 3e-08 33.2 0.0 1.9 1 1 0 1 1 1 1 NB-ARC domain TPR_2 PF07719.17 EMD64013.1 - 3.3e-08 33.0 5.2 2.3 8.6 0.0 7.3 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_17 PF13431.6 EMD64013.1 - 1.1e-07 31.7 0.2 5.4 7.6 0.0 5.7 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_8 PF13181.6 EMD64013.1 - 1.8e-06 27.7 4.2 20 5.7 0.0 6.0 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_MalT PF17874.1 EMD64013.1 - 7.9e-06 25.5 4.0 0.00028 20.4 2.3 2.4 1 1 1 2 2 2 2 MalT-like TPR region AAA_16 PF13191.6 EMD64013.1 - 1e-05 26.0 0.2 2.2e-05 24.9 0.2 1.8 1 1 0 1 1 1 1 AAA ATPase domain TPR_19 PF14559.6 EMD64013.1 - 0.00012 22.5 2.3 1.6 9.3 0.1 4.3 2 1 3 5 5 5 1 Tetratricopeptide repeat ATPase_2 PF01637.18 EMD64013.1 - 0.00037 20.5 0.0 0.00066 19.7 0.0 1.4 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea NACHT PF05729.12 EMD64013.1 - 0.0024 17.8 0.0 0.0063 16.5 0.0 1.8 1 1 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 EMD64013.1 - 0.0083 16.4 0.0 0.058 13.7 0.0 2.4 2 0 0 2 2 2 1 AAA domain MIT PF04212.18 EMD64013.1 - 0.13 12.3 5.8 8.9 6.5 0.0 4.1 5 0 0 5 5 4 0 MIT (microtubule interacting and transport) domain TPR_14 PF13428.6 EMD64013.1 - 9.3 7.4 9.2 1.3e+02 3.8 0.0 5.9 6 1 1 7 7 6 0 Tetratricopeptide repeat Peptidase_S41 PF03572.18 EMD64014.1 - 1e-08 34.9 0.0 3e-08 33.4 0.0 1.7 1 1 0 1 1 1 1 Peptidase family S41 Trp_DMAT PF11991.8 EMD64015.1 - 5.2e-33 114.9 0.0 1.3e-32 113.7 0.0 1.5 1 1 0 1 1 1 1 Tryptophan dimethylallyltransferase HlyC PF02794.16 EMD64015.1 - 0.27 11.1 0.7 0.55 10.1 0.0 1.8 2 1 0 2 2 2 0 RTX toxin acyltransferase family MFS_1 PF07690.16 EMD64017.1 - 5.2e-40 137.4 48.4 5.2e-40 137.4 48.4 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EMD64017.1 - 7.5e-14 51.1 29.7 1.6e-13 50.0 29.7 1.4 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EMD64017.1 - 6.4e-12 45.1 12.2 6.4e-12 45.1 12.2 2.4 2 0 0 2 2 2 1 Sugar (and other) transporter PS-DH PF14765.6 EMD64018.1 - 6.9e-62 209.4 0.0 1.1e-61 208.7 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase ketoacyl-synt PF00109.26 EMD64018.1 - 4e-57 193.7 0.0 9.9e-57 192.4 0.0 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.10 EMD64018.1 - 9.3e-57 191.8 0.7 3e-56 190.2 0.3 2.1 2 0 0 2 2 2 1 KR domain Acyl_transf_1 PF00698.21 EMD64018.1 - 1e-50 173.1 0.3 1.6e-50 172.5 0.3 1.2 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EMD64018.1 - 2.5e-34 117.8 0.1 7.7e-34 116.2 0.1 1.9 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain ADH_zinc_N_2 PF13602.6 EMD64018.1 - 1e-18 68.7 0.0 2.4e-17 64.2 0.0 3.1 3 0 0 3 3 3 1 Zinc-binding dehydrogenase KAsynt_C_assoc PF16197.5 EMD64018.1 - 3.2e-18 66.2 0.0 1e-17 64.6 0.0 2.0 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Methyltransf_12 PF08242.12 EMD64018.1 - 5.7e-17 62.3 0.0 1.4e-16 61.0 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain ADH_zinc_N PF00107.26 EMD64018.1 - 2.8e-16 59.7 0.0 1.1e-14 54.6 0.0 3.0 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Methyltransf_23 PF13489.6 EMD64018.1 - 1.1e-11 44.8 0.0 4.6e-11 42.8 0.0 2.1 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMD64018.1 - 3.8e-10 39.7 0.0 7.5e-10 38.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMD64018.1 - 6.1e-10 39.7 0.0 2.2e-09 37.9 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMD64018.1 - 5.2e-09 36.6 0.0 2e-08 34.7 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain adh_short PF00106.25 EMD64018.1 - 2e-08 33.9 0.4 5.1e-06 26.1 0.2 2.9 3 0 0 3 3 3 1 short chain dehydrogenase ADH_N PF08240.12 EMD64018.1 - 1.2e-07 31.6 0.1 3.2e-07 30.2 0.1 1.8 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain PP-binding PF00550.25 EMD64018.1 - 2.4e-05 24.6 0.1 7.2e-05 23.1 0.1 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site adh_short_C2 PF13561.6 EMD64018.1 - 0.0083 15.7 0.4 0.035 13.6 0.2 2.0 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase Thiolase_N PF00108.23 EMD64018.1 - 0.047 13.0 0.1 0.047 13.0 0.1 2.2 2 0 0 2 2 2 0 Thiolase, N-terminal domain RrnaAD PF00398.20 EMD64018.1 - 0.062 12.4 0.0 0.1 11.6 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Methyltransf_16 PF10294.9 EMD64018.1 - 0.1 12.3 0.4 2.2 8.0 0.1 2.8 2 1 0 2 2 2 0 Lysine methyltransferase UbiA PF01040.18 EMD64019.1 - 8e-10 38.4 10.5 8.6e-10 38.3 10.5 1.0 1 0 0 1 1 1 1 UbiA prenyltransferase family DUF498 PF04430.14 EMD64020.1 - 1.3e-29 102.4 0.0 1.9e-29 101.9 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF498/DUF598) DUF4208 PF13907.6 EMD64021.1 - 3.7e-18 65.7 0.0 6.1e-18 65.1 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4208) Beta-lactamase PF00144.24 EMD64022.1 - 6.2e-60 203.2 0.0 7.7e-60 202.9 0.0 1.0 1 0 0 1 1 1 1 Beta-lactamase Cutinase PF01083.22 EMD64024.1 - 1.4e-30 106.5 1.3 1.8e-30 106.2 1.3 1.1 1 0 0 1 1 1 1 Cutinase PE-PPE PF08237.11 EMD64024.1 - 0.1 12.1 0.2 0.15 11.6 0.2 1.2 1 0 0 1 1 1 0 PE-PPE domain Chlam_OMP3 PF03503.13 EMD64024.1 - 0.14 12.5 3.1 0.29 11.5 3.1 1.5 1 0 0 1 1 1 0 Chlamydia cysteine-rich outer membrane protein 3 Glyco_hydro_43 PF04616.14 EMD64025.1 - 1.9e-29 102.9 0.4 2.4e-29 102.6 0.4 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 DUF5348 PF17295.2 EMD64025.1 - 0.19 11.6 0.8 1.5 8.8 0.8 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF5348) GIT_SHD PF08518.11 EMD64026.1 - 5.1e-22 77.2 7.7 4.5e-12 45.4 0.6 2.7 2 0 0 2 2 2 2 Spa2 homology domain (SHD) of GIT Filament PF00038.21 EMD64026.1 - 3.8e-05 23.4 18.9 0.00035 20.3 3.2 2.4 2 0 0 2 2 2 2 Intermediate filament protein CENP-F_leu_zip PF10473.9 EMD64026.1 - 0.00078 19.5 30.0 0.032 14.3 8.3 3.2 2 1 0 2 2 2 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Rootletin PF15035.6 EMD64026.1 - 0.002 18.2 10.3 0.002 18.2 10.3 2.6 1 1 0 2 2 2 1 Ciliary rootlet component, centrosome cohesion SlyX PF04102.12 EMD64026.1 - 0.022 15.3 26.0 0.19 12.3 2.4 4.9 2 2 1 3 3 3 0 SlyX SHE3 PF17078.5 EMD64026.1 - 0.036 13.8 19.1 0.033 13.9 2.9 2.5 2 0 0 2 2 2 0 SWI5-dependent HO expression protein 3 Lectin_N PF03954.14 EMD64026.1 - 0.037 13.8 9.9 0.37 10.6 3.2 3.6 1 1 2 3 3 3 0 Hepatic lectin, N-terminal domain DUF4200 PF13863.6 EMD64026.1 - 0.11 13.0 35.6 0.048 14.1 12.8 3.0 3 0 0 3 3 2 0 Domain of unknown function (DUF4200) Syntaxin_2 PF14523.6 EMD64026.1 - 0.12 12.8 0.1 0.12 12.8 0.1 4.8 3 1 0 3 3 2 0 Syntaxin-like protein HCMV_UL139 PF12507.8 EMD64026.1 - 0.12 12.8 3.9 0.37 11.2 0.5 2.7 2 1 0 2 2 1 0 Human Cytomegalovirus UL139 protein Jnk-SapK_ap_N PF09744.9 EMD64026.1 - 0.12 12.6 36.9 0.28 11.4 5.2 3.7 1 1 2 3 3 3 0 JNK_SAPK-associated protein-1 DUF3573 PF12097.8 EMD64026.1 - 0.26 10.1 1.6 0.62 8.8 1.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) BLOC1_2 PF10046.9 EMD64026.1 - 0.29 11.5 20.9 0.38 11.1 3.2 4.0 4 0 0 4 4 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 CALCOCO1 PF07888.11 EMD64026.1 - 0.42 9.4 34.4 0.04 12.8 14.4 2.3 1 1 1 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like DUF5082 PF16888.5 EMD64026.1 - 0.46 10.8 18.8 0.3 11.4 10.4 3.7 2 1 0 2 2 2 0 Domain of unknown function (DUF5082) UPF0242 PF06785.11 EMD64026.1 - 0.57 10.2 24.0 0.02 15.0 8.5 2.7 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus ATG16 PF08614.11 EMD64026.1 - 0.63 10.2 39.9 0.81 9.9 15.9 2.7 2 1 1 3 3 2 0 Autophagy protein 16 (ATG16) DUF3450 PF11932.8 EMD64026.1 - 0.68 9.2 27.0 0.082 12.2 6.1 3.4 2 1 1 3 3 3 0 Protein of unknown function (DUF3450) Baculo_PEP_C PF04513.12 EMD64026.1 - 0.68 10.0 16.3 5.4 7.0 0.1 4.9 4 1 0 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus ADIP PF11559.8 EMD64026.1 - 0.69 10.0 30.5 0.092 12.8 6.6 3.7 2 2 1 3 3 3 0 Afadin- and alpha -actinin-Binding Fez1 PF06818.15 EMD64026.1 - 0.85 10.0 27.6 0.46 10.9 15.9 2.7 1 1 1 2 2 2 0 Fez1 DUF1664 PF07889.12 EMD64026.1 - 0.92 9.6 18.1 1.3 9.1 2.1 4.4 4 0 0 4 4 4 0 Protein of unknown function (DUF1664) Tropomyosin_1 PF12718.7 EMD64026.1 - 0.97 9.6 37.1 3 8.0 23.1 3.3 2 1 1 3 3 3 0 Tropomyosin like Tropomyosin PF00261.20 EMD64026.1 - 1.6 8.1 33.7 0.036 13.4 11.3 3.2 2 2 0 2 2 2 0 Tropomyosin HIP1_clath_bdg PF16515.5 EMD64026.1 - 2.6 8.7 31.2 2.8 8.6 10.8 3.6 2 1 1 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Laminin_II PF06009.12 EMD64026.1 - 2.8 8.0 22.6 3.2 7.8 2.4 3.6 3 0 0 3 3 3 0 Laminin Domain II V_ATPase_I PF01496.19 EMD64026.1 - 2.9 5.7 14.2 0.2 9.6 2.7 2.3 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Prefoldin_2 PF01920.20 EMD64026.1 - 2.9 7.9 26.2 2.1 8.4 10.4 4.4 2 2 0 2 2 2 0 Prefoldin subunit TolA_bind_tri PF16331.5 EMD64026.1 - 4.6 7.4 31.5 7.1 6.8 6.0 3.8 2 1 1 3 3 3 0 TolA binding protein trimerisation DUF4407 PF14362.6 EMD64026.1 - 5 6.4 28.3 0.055 12.8 10.7 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF4407) Mod_r PF07200.13 EMD64026.1 - 8 6.6 26.0 11 6.1 8.1 3.6 2 1 0 3 3 3 0 Modifier of rudimentary (Mod(r)) protein ZapB PF06005.12 EMD64026.1 - 8.7 6.9 35.6 6.3 7.3 2.8 4.1 3 1 1 4 4 3 0 Cell division protein ZapB bZIP_1 PF00170.21 EMD64026.1 - 9.6 6.4 26.3 0.041 14.0 2.8 4.3 3 1 1 4 4 4 0 bZIP transcription factor BST2 PF16716.5 EMD64026.1 - 9.7 6.9 29.0 1.2 9.8 2.1 3.7 2 1 1 3 3 3 0 Bone marrow stromal antigen 2 ING PF12998.7 EMD64028.1 - 4.1e-23 81.9 2.4 6.9e-23 81.2 2.4 1.4 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 EMD64028.1 - 1e-05 25.3 9.4 1.6e-05 24.7 9.4 1.3 1 0 0 1 1 1 1 PHD-finger LRRFIP PF09738.9 EMD64028.1 - 0.0062 16.1 0.3 0.0062 16.1 0.3 1.6 2 0 0 2 2 2 1 LRRFIP family PKcGMP_CC PF16808.5 EMD64028.1 - 0.0068 16.2 1.2 0.014 15.2 0.1 2.0 2 0 0 2 2 2 1 Coiled-coil N-terminus of cGMP-dependent protein kinase PHD_2 PF13831.6 EMD64028.1 - 0.017 14.7 2.5 0.028 14.0 2.5 1.4 1 0 0 1 1 1 0 PHD-finger zf-HC5HC2H PF13771.6 EMD64028.1 - 0.018 15.3 0.2 0.037 14.3 0.2 1.5 1 0 0 1 1 1 0 PHD-like zinc-binding domain CENP-F_leu_zip PF10473.9 EMD64028.1 - 0.12 12.4 2.3 0.47 10.5 0.1 2.2 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GAT PF03127.14 EMD64028.1 - 0.14 12.5 0.2 0.14 12.5 0.2 1.7 2 0 0 2 2 2 0 GAT domain zf-RING_4 PF14570.6 EMD64028.1 - 8 6.3 9.8 0.89 9.4 3.3 2.1 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain Hist_deacetyl PF00850.19 EMD64029.1 - 9.7e-76 255.2 0.0 1.3e-75 254.8 0.0 1.2 1 0 0 1 1 1 1 Histone deacetylase domain Fungal_trans PF04082.18 EMD64030.1 - 6.8e-13 48.3 0.0 1.5e-12 47.1 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD64030.1 - 1.1e-09 38.3 12.1 2.6e-09 37.0 12.1 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain 2-Hacid_dh_C PF02826.19 EMD64031.1 - 1.8e-38 131.7 0.1 2.4e-38 131.3 0.1 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EMD64031.1 - 2.7e-06 27.1 0.0 4.2e-06 26.5 0.0 1.3 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 EMD64031.1 - 0.00083 19.6 0.0 0.0016 18.7 0.0 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 EMD64031.1 - 0.004 17.7 0.0 0.022 15.4 0.0 2.1 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent UDPG_MGDP_dh_C PF03720.15 EMD64031.1 - 0.13 12.7 0.0 0.44 11.0 0.0 1.9 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain TRI12 PF06609.13 EMD64032.1 - 3.3e-74 250.4 16.9 4.3e-74 250.0 16.9 1.0 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_1 PF07690.16 EMD64032.1 - 2.7e-18 66.0 47.7 5.1e-16 58.5 49.2 2.8 2 1 0 2 2 2 1 Major Facilitator Superfamily TMEM100 PF16311.5 EMD64032.1 - 0.44 10.1 1.6 4.1 7.0 0.0 2.8 3 0 0 3 3 3 0 Transmembrane protein 100 Ost5 PF05251.12 EMD64032.1 - 9.3 6.6 12.2 26 5.1 1.9 4.7 4 0 0 4 4 4 0 Oligosaccharyltransferase subunit 5 RNA_pol_Rpc34 PF05158.12 EMD64033.1 - 5.8e-74 249.5 0.3 3e-73 247.1 0.3 1.8 1 1 0 1 1 1 1 RNA polymerase Rpc34 subunit HxlR PF01638.17 EMD64033.1 - 0.0029 17.4 0.1 0.0081 16.0 0.1 1.7 1 0 0 1 1 1 1 HxlR-like helix-turn-helix HTH_27 PF13463.6 EMD64033.1 - 0.0075 16.7 0.0 0.022 15.2 0.0 1.8 1 0 0 1 1 1 1 Winged helix DNA-binding domain MarR PF01047.22 EMD64033.1 - 0.013 15.4 0.1 0.037 13.9 0.1 1.7 1 0 0 1 1 1 0 MarR family B-block_TFIIIC PF04182.12 EMD64033.1 - 0.021 15.0 0.1 0.038 14.1 0.1 1.4 1 0 0 1 1 1 0 B-block binding subunit of TFIIIC MarR_2 PF12802.7 EMD64033.1 - 0.022 14.7 0.0 0.048 13.5 0.0 1.6 1 0 0 1 1 1 0 MarR family Rrf2 PF02082.20 EMD64033.1 - 0.027 14.8 0.2 0.17 12.3 0.1 2.2 2 0 0 2 2 2 0 Transcriptional regulator GntR PF00392.21 EMD64033.1 - 0.072 12.8 0.0 0.21 11.3 0.0 1.7 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family FANCI_S1-cap PF14674.6 EMD64033.1 - 0.29 11.2 1.4 16 5.6 0.1 2.7 2 0 0 2 2 2 0 FANCI solenoid 1 cap ANAPC2 PF08672.11 EMD64033.1 - 0.92 10.1 4.2 1.7 9.2 0.1 2.9 3 0 0 3 3 3 0 Anaphase promoting complex (APC) subunit 2 Alk_phosphatase PF00245.20 EMD64034.1 - 3.2e-108 362.4 1.3 4.1e-108 362.0 1.3 1.1 1 0 0 1 1 1 1 Alkaline phosphatase Metalloenzyme PF01676.18 EMD64034.1 - 1.6e-05 24.4 0.0 3e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Metalloenzyme superfamily Adeno_E3 PF06040.11 EMD64034.1 - 0.026 14.7 0.0 0.071 13.3 0.0 1.7 1 0 0 1 1 1 0 Adenovirus E3 protein Zn_clus PF00172.18 EMD64035.1 - 1.8e-06 28.0 9.7 2.8e-06 27.3 9.7 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Ribosomal_L34e PF01199.18 EMD64036.1 - 8.7e-44 147.8 3.7 1.2e-43 147.3 3.7 1.2 1 0 0 1 1 1 1 Ribosomal protein L34e DZR PF12773.7 EMD64036.1 - 0.0075 16.3 0.5 0.012 15.7 0.5 1.3 1 0 0 1 1 1 1 Double zinc ribbon PROCN PF08083.11 EMD64037.1 - 5.6e-235 779.5 9.0 5.6e-235 779.5 9.0 2.6 3 0 0 3 3 3 1 PROCN (NUC071) domain PRP8_domainIV PF12134.8 EMD64037.1 - 1.1e-126 421.0 1.1 2.1e-126 420.2 1.1 1.4 1 0 0 1 1 1 1 PRP8 domain IV core U6-snRNA_bdg PF10596.9 EMD64037.1 - 2e-88 294.3 2.1 7.1e-88 292.6 2.1 2.1 1 0 0 1 1 1 1 U6-snRNA interacting domain of PrP8 PRO8NT PF08082.11 EMD64037.1 - 4.1e-78 260.6 1.1 4.1e-78 260.6 1.1 2.0 2 0 0 2 2 2 1 PRO8NT (NUC069), PrP8 N-terminal domain U5_2-snRNA_bdg PF10597.9 EMD64037.1 - 7e-71 236.6 0.1 1.4e-70 235.6 0.1 1.6 1 0 0 1 1 1 1 U5-snRNA binding site 2 of PrP8 PROCT PF08084.11 EMD64037.1 - 8.1e-48 161.4 0.0 3.9e-47 159.2 0.0 2.2 2 0 0 2 2 2 1 PROCT (NUC072) domain RRM_4 PF10598.9 EMD64037.1 - 2.7e-47 159.1 1.0 8.1e-47 157.5 1.0 1.9 1 0 0 1 1 1 1 RNA recognition motif of the spliceosomal PrP8 DUF536 PF04394.14 EMD64037.1 - 0.062 13.2 4.3 0.24 11.3 4.3 2.0 1 0 0 1 1 1 0 Protein of unknown function, DUF536 PTR2 PF00854.21 EMD64038.1 - 2e-78 264.0 7.7 2.5e-78 263.7 7.7 1.1 1 0 0 1 1 1 1 POT family LETM1 PF07766.13 EMD64038.1 - 0.088 12.1 0.0 0.14 11.4 0.0 1.3 1 0 0 1 1 1 0 LETM1-like protein CHAT PF12770.7 EMD64040.1 - 5.2e-10 39.2 0.0 8.4e-10 38.5 0.0 1.3 1 1 0 1 1 1 1 CHAT domain Cupin_2 PF07883.11 EMD64041.1 - 3.8e-05 23.3 0.3 0.27 11.0 0.0 2.4 2 0 0 2 2 2 2 Cupin domain Cupin_1 PF00190.22 EMD64041.1 - 0.00052 19.6 0.4 0.0011 18.6 0.3 1.5 1 1 0 1 1 1 1 Cupin 2OG-FeII_Oxy_5 PF13759.6 EMD64041.1 - 0.12 12.8 0.1 16 6.0 0.0 2.3 1 1 1 2 2 2 0 Putative 2OG-Fe(II) oxygenase ADH_zinc_N_2 PF13602.6 EMD64042.1 - 2.8e-12 47.8 0.0 4.4e-12 47.2 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EMD64042.1 - 8e-09 35.4 0.0 1.8e-08 34.2 0.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EMD64042.1 - 1.2e-07 31.8 0.0 1.9e-07 31.1 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase PCNA_C PF02747.15 EMD64042.1 - 0.034 14.3 0.0 0.059 13.5 0.0 1.4 1 0 0 1 1 1 0 Proliferating cell nuclear antigen, C-terminal domain YqaJ PF09588.10 EMD64044.1 - 0.06 13.5 0.0 0.14 12.3 0.0 1.6 1 0 0 1 1 1 0 YqaJ-like viral recombinase domain Abhydrolase_1 PF00561.20 EMD64045.1 - 7.9e-13 48.6 0.0 1.2e-11 44.8 0.0 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EMD64045.1 - 8.5e-06 26.5 0.0 1.1e-05 26.1 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EMD64045.1 - 5.7e-05 22.5 0.0 9.5e-05 21.8 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Esterase PF00756.20 EMD64045.1 - 0.11 12.1 0.0 0.14 11.7 0.0 1.4 1 1 0 1 1 1 0 Putative esterase DUF5521 PF17659.1 EMD64046.1 - 0.085 10.7 0.6 0.11 10.3 0.6 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5521) DUF737 PF05300.11 EMD64046.1 - 5.9 7.2 8.0 1.5 9.2 2.7 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF737) TPR_1 PF00515.28 EMD64047.1 - 3.7e-50 165.8 23.2 2.9e-06 26.9 0.0 9.7 10 0 0 10 10 9 9 Tetratricopeptide repeat TPR_2 PF07719.17 EMD64047.1 - 1.5e-39 130.9 19.9 6.6e-05 22.7 0.1 9.7 9 0 0 9 9 9 9 Tetratricopeptide repeat STI1 PF17830.1 EMD64047.1 - 4.5e-38 129.0 14.4 8e-22 76.9 4.4 3.1 4 0 0 4 4 2 2 STI1 domain TPR_11 PF13414.6 EMD64047.1 - 5.2e-26 90.0 14.4 2.8e-05 23.7 0.0 8.1 6 2 2 8 8 8 6 TPR repeat TPR_8 PF13181.6 EMD64047.1 - 2.5e-21 74.0 21.0 0.0042 17.2 0.4 9.3 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_19 PF14559.6 EMD64047.1 - 6.5e-17 61.8 6.6 0.005 17.3 0.1 7.2 5 2 2 7 7 7 5 Tetratricopeptide repeat TPR_12 PF13424.6 EMD64047.1 - 1.7e-13 50.7 12.5 1.8e-07 31.3 0.6 6.5 4 3 2 6 6 6 3 Tetratricopeptide repeat TPR_14 PF13428.6 EMD64047.1 - 1.7e-13 50.1 16.0 1.7 9.7 0.1 9.3 7 2 3 10 10 9 3 Tetratricopeptide repeat TPR_17 PF13431.6 EMD64047.1 - 1.8e-13 49.8 4.2 0.038 14.4 0.0 8.1 7 1 1 8 8 8 2 Tetratricopeptide repeat TPR_16 PF13432.6 EMD64047.1 - 1.4e-12 48.0 9.3 0.00079 20.0 0.0 6.7 4 1 3 8 8 7 4 Tetratricopeptide repeat TPR_9 PF13371.6 EMD64047.1 - 6.1e-12 45.5 0.4 0.00073 19.6 0.0 4.3 5 1 0 5 5 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 EMD64047.1 - 2.5e-09 36.5 9.5 0.071 13.2 0.0 7.5 8 1 1 9 9 8 3 Tetratricopeptide repeat TPR_6 PF13174.6 EMD64047.1 - 2e-08 34.3 14.4 0.19 12.4 0.3 9.0 9 0 0 9 9 9 2 Tetratricopeptide repeat TPR_10 PF13374.6 EMD64047.1 - 4.6e-05 23.2 5.5 0.053 13.4 0.0 5.4 4 1 1 5 5 5 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EMD64047.1 - 0.0003 20.8 6.6 0.21 11.7 0.0 5.5 6 0 0 6 6 6 1 Fis1 C-terminal tetratricopeptide repeat ANAPC3 PF12895.7 EMD64047.1 - 0.0012 19.0 9.4 0.36 11.1 0.6 4.5 2 1 1 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_3 PF07720.12 EMD64047.1 - 0.038 14.0 4.4 27 4.9 0.2 4.7 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF384 PF04064.13 EMD64047.1 - 0.05 13.5 0.3 0.26 11.2 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF384) TPR_20 PF14561.6 EMD64047.1 - 0.051 13.9 12.3 2.1 8.8 0.0 5.6 6 2 0 6 6 6 0 Tetratricopeptide repeat DUF501 PF04417.12 EMD64047.1 - 0.77 9.6 5.3 1.4 8.7 0.1 3.5 2 1 2 4 4 4 0 Protein of unknown function (DUF501) FAT PF02259.23 EMD64047.1 - 2.2 7.4 7.2 1.8 7.7 3.1 2.5 2 0 0 2 2 2 0 FAT domain ProQ PF04352.13 EMD64047.1 - 5.8 6.9 13.5 0.07 13.0 3.6 2.7 2 1 1 3 3 3 0 ProQ/FINO family SPESP1 PF15754.5 EMD64047.1 - 9 5.4 9.3 1.1 8.4 4.8 1.7 2 0 0 2 2 2 0 Sperm equatorial segment protein 1 FolB PF02152.18 EMD64048.1 - 1.6e-30 105.9 0.0 7.1e-21 74.8 0.0 2.1 2 0 0 2 2 2 2 Dihydroneopterin aldolase UDPGP PF01704.18 EMD64049.1 - 3e-190 632.2 0.0 3.6e-190 632.0 0.0 1.1 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase C2 PF00168.30 EMD64051.1 - 1.3e-81 269.5 0.2 1.4e-21 76.7 0.0 5.8 6 0 0 6 6 6 5 C2 domain SMP_LBD PF17047.5 EMD64051.1 - 9.1e-05 22.0 0.0 0.00016 21.2 0.0 1.3 1 0 0 1 1 1 1 Synaptotagmin-like mitochondrial-lipid-binding domain VHS PF00790.19 EMD64053.1 - 0.087 12.7 0.1 0.14 12.0 0.1 1.3 1 0 0 1 1 1 0 VHS domain Striatin PF08232.12 EMD64055.1 - 2.4 8.7 11.3 0.19 12.3 6.8 1.4 2 0 0 2 2 2 0 Striatin family DUF1593 PF07632.11 EMD64057.1 - 8e-93 310.6 0.0 1.1e-92 310.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1593) REJ PF02010.15 EMD64057.1 - 0.015 14.2 0.0 0.022 13.6 0.0 1.2 1 0 0 1 1 1 0 REJ domain OmpH PF03938.14 EMD64058.1 - 0.0085 16.4 1.1 0.0085 16.4 1.1 3.8 3 1 1 4 4 4 1 Outer membrane protein (OmpH-like) DUF4618 PF15397.6 EMD64058.1 - 0.18 11.2 22.9 0.02 14.3 7.0 3.5 3 1 1 4 4 4 0 Domain of unknown function (DUF4618) Dynein_C PF18199.1 EMD64058.1 - 0.27 10.4 2.4 5 6.3 0.4 2.2 2 0 0 2 2 2 0 Dynein heavy chain C-terminal domain DUF2117 PF09890.9 EMD64058.1 - 0.28 10.6 1.6 0.84 9.1 0.0 2.1 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2117) V-ATPase_G PF03179.15 EMD64058.1 - 1.6 9.3 23.8 0.071 13.6 10.7 3.3 2 1 1 3 3 3 0 Vacuolar (H+)-ATPase G subunit PspA_IM30 PF04012.12 EMD64058.1 - 4.7 6.7 38.7 0.12 11.9 4.1 4.1 3 1 0 4 4 4 0 PspA/IM30 family NPV_P10 PF05531.12 EMD64058.1 - 6.2 7.4 9.8 49 4.5 0.0 4.3 4 1 0 4 4 4 0 Nucleopolyhedrovirus P10 protein FliD_N PF02465.18 EMD64058.1 - 9.9 6.9 15.0 2 9.2 0.7 3.5 3 1 1 4 4 4 0 Flagellar hook-associated protein 2 N-terminus NPP1 PF05630.11 EMD64059.1 - 7.4e-63 212.2 0.0 8.5e-63 212.0 0.0 1.0 1 0 0 1 1 1 1 Necrosis inducing protein (NPP1) Metallophos PF00149.28 EMD64060.1 - 3.1e-15 57.2 0.3 5.4e-15 56.4 0.3 1.4 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EMD64060.1 - 3e-07 30.8 0.0 3.9e-05 23.9 0.0 2.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain SGL PF08450.12 EMD64061.1 - 2e-21 76.7 0.1 3e-21 76.1 0.1 1.2 1 0 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Arylesterase PF01731.20 EMD64061.1 - 0.047 13.9 0.0 0.14 12.3 0.0 1.8 1 0 0 1 1 1 0 Arylesterase zf-CCCH PF00642.24 EMD64062.1 - 9.5e-09 35.0 17.7 3e-07 30.2 2.5 2.9 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RRM_1 PF00076.22 EMD64062.1 - 4.9e-06 26.3 0.0 8e-06 25.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf_CCCH_4 PF18345.1 EMD64062.1 - 0.0058 16.6 3.3 0.0058 16.6 3.3 2.9 3 0 0 3 3 3 1 Zinc finger domain Torus PF16131.5 EMD64062.1 - 0.011 16.5 3.5 0.51 11.1 0.2 2.5 2 0 0 2 2 2 0 Torus domain zf-CCCH_3 PF15663.5 EMD64062.1 - 0.28 11.4 6.8 0.23 11.7 0.9 2.4 2 1 0 2 2 2 0 Zinc-finger containing family DUF3040 PF11239.8 EMD64063.1 - 0.0044 17.3 0.3 0.016 15.5 0.1 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3040) DUF3605 PF12239.8 EMD64065.1 - 8.9e-58 195.0 3.9 1.1e-57 194.7 3.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3605) HMG-CoA_red PF00368.18 EMD64066.1 - 2.4e-138 461.2 4.7 1.1e-137 459.0 5.8 1.5 2 0 0 2 2 2 1 Hydroxymethylglutaryl-coenzyme A reductase HPIH PF13323.6 EMD64066.1 - 3.9e-41 140.5 1.5 7.4e-41 139.6 1.5 1.5 1 0 0 1 1 1 1 N-terminal domain with HPIH motif Sterol-sensing PF12349.8 EMD64066.1 - 7.6e-16 58.3 3.8 1.8e-15 57.1 3.8 1.6 1 0 0 1 1 1 1 Sterol-sensing domain of SREBP cleavage-activation Patched PF02460.18 EMD64066.1 - 5.5e-06 24.8 3.6 5.5e-06 24.8 3.6 1.7 2 0 0 2 2 2 1 Patched family Pkinase PF00069.25 EMD64067.1 - 7.8e-72 241.8 0.0 1.2e-71 241.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD64067.1 - 9.1e-37 126.7 0.0 2.3e-36 125.4 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMD64067.1 - 0.001 18.5 0.9 1.4 8.2 0.0 2.9 3 0 0 3 3 3 2 Kinase-like Pkinase_fungal PF17667.1 EMD64067.1 - 0.013 14.4 0.5 0.028 13.2 0.0 1.8 3 0 0 3 3 3 0 Fungal protein kinase APH PF01636.23 EMD64067.1 - 0.023 14.7 1.2 0.98 9.3 0.0 2.8 2 1 1 3 3 3 0 Phosphotransferase enzyme family DUF4611 PF15387.6 EMD64067.1 - 1.5 9.0 5.8 0.29 11.4 1.6 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) SET PF00856.28 EMD64068.1 - 1.6e-15 57.9 0.0 2.6e-15 57.2 0.0 1.3 1 0 0 1 1 1 1 SET domain DUF2116 PF09889.9 EMD64068.1 - 0.16 12.0 0.1 0.5 10.4 0.1 1.8 1 0 0 1 1 1 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) Metallopep PF12044.8 EMD64069.1 - 8.8e-130 433.1 0.0 1.1e-129 432.8 0.0 1.1 1 0 0 1 1 1 1 Putative peptidase family Reprolysin_3 PF13582.6 EMD64069.1 - 0.023 15.2 0.5 0.061 13.8 0.5 1.8 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like zf-C4_ClpX PF06689.13 EMD64069.1 - 0.06 13.2 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 ClpX C4-type zinc finger Molybdopterin_N PF18364.1 EMD64069.1 - 0.15 12.1 1.3 6.4 6.9 0.2 2.8 2 0 0 2 2 2 0 Molybdopterin oxidoreductase N-terminal domain Peptidase_M66 PF10462.9 EMD64069.1 - 0.23 10.4 0.6 0.69 8.8 0.6 1.8 1 0 0 1 1 1 0 Peptidase M66 LPMO_10 PF03067.15 EMD64070.1 - 0.021 15.5 0.9 0.049 14.3 0.8 1.8 1 1 0 1 1 1 0 Lytic polysaccharide mono-oxygenase, cellulose-degrading Glyco_hydro_76 PF03663.14 EMD64072.1 - 4.2e-82 276.6 6.1 5.5e-82 276.2 6.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 EMD64072.1 - 0.0012 18.0 1.1 0.23 10.5 0.1 2.4 2 0 0 2 2 2 2 Glycosyl Hydrolase Family 88 GlcNAc_2-epim PF07221.11 EMD64072.1 - 0.031 13.5 4.1 0.08 12.2 2.3 2.2 1 1 2 3 3 3 0 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) Pectate_lyase PF03211.13 EMD64074.1 - 1.2e-84 283.0 10.8 1.4e-84 282.7 10.8 1.0 1 0 0 1 1 1 1 Pectate lyase DUF732 PF05305.14 EMD64074.1 - 2.7 8.4 6.6 3 8.3 1.8 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF732) Fungal_trans_2 PF11951.8 EMD64075.1 - 1.1e-07 31.0 0.0 1.6e-07 30.5 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD64075.1 - 0.00031 20.8 10.6 0.00051 20.1 10.6 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Ssu72 PF04722.13 EMD64077.1 - 2.6e-79 265.3 0.0 3e-79 265.1 0.0 1.0 1 0 0 1 1 1 1 Ssu72-like protein PRIMA1 PF16101.5 EMD64077.1 - 3.4 7.7 5.5 5.5 7.1 5.5 1.3 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 SH3_1 PF00018.28 EMD64078.1 - 1.5e-09 37.3 0.0 3.2e-09 36.3 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EMD64078.1 - 1.9e-09 37.2 0.1 1.9e-09 37.2 0.1 2.6 3 0 0 3 3 3 1 Variant SH3 domain SH3_2 PF07653.17 EMD64078.1 - 9.3e-06 25.2 0.0 2e-05 24.2 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain Abhydrolase_6 PF12697.7 EMD64079.1 - 2e-19 71.1 1.3 4.6e-19 69.9 1.3 1.6 1 0 0 1 1 1 1 Alpha/beta hydrolase family DSPc PF00782.20 EMD64079.1 - 4.4e-11 42.7 0.0 7.8e-11 41.9 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Abhydrolase_1 PF00561.20 EMD64079.1 - 5.1e-11 42.7 0.0 1.2e-10 41.5 0.0 1.6 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EMD64079.1 - 2.1e-10 40.3 0.0 2.4e-09 36.8 0.0 2.2 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 EMD64079.1 - 0.00017 21.8 0.2 0.00031 21.0 0.2 1.3 1 0 0 1 1 1 1 Thioesterase domain PGAP1 PF07819.13 EMD64079.1 - 0.0013 18.5 0.1 0.025 14.3 0.0 2.2 2 0 0 2 2 2 1 PGAP1-like protein PTPlike_phytase PF14566.6 EMD64079.1 - 0.0022 18.1 0.0 0.0039 17.3 0.0 1.3 1 0 0 1 1 1 1 Inositol hexakisphosphate Lipase_3 PF01764.25 EMD64079.1 - 0.0026 17.6 0.5 0.017 15.0 0.1 2.0 1 1 1 2 2 2 1 Lipase (class 3) Y_phosphatase PF00102.27 EMD64079.1 - 0.0027 17.3 0.0 0.0073 15.9 0.0 1.7 2 0 0 2 2 2 1 Protein-tyrosine phosphatase Esterase PF00756.20 EMD64079.1 - 0.0053 16.4 0.0 0.011 15.4 0.0 1.5 1 0 0 1 1 1 1 Putative esterase Ser_hydrolase PF06821.13 EMD64079.1 - 0.006 16.4 0.3 0.013 15.4 0.3 1.5 1 0 0 1 1 1 1 Serine hydrolase LCAT PF02450.15 EMD64079.1 - 0.019 14.2 0.0 0.029 13.6 0.0 1.2 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase Chlorophyllase2 PF12740.7 EMD64079.1 - 0.053 12.4 0.1 0.11 11.3 0.1 1.5 1 1 0 1 1 1 0 Chlorophyllase enzyme LIDHydrolase PF10230.9 EMD64079.1 - 0.16 11.5 0.0 0.33 10.5 0.0 1.4 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase DUF900 PF05990.12 EMD64079.1 - 0.24 10.9 0.0 0.42 10.1 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) ILVD_EDD PF00920.21 EMD64080.1 - 6.5e-209 694.8 2.5 7.4e-209 694.6 2.5 1.0 1 0 0 1 1 1 1 Dehydratase family Ribosomal_S19e PF01090.19 EMD64081.1 - 4e-58 195.0 0.2 4.6e-58 194.8 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S19e Sortilin-Vps10 PF15902.5 EMD64082.1 - 0.0013 17.6 0.4 0.76 8.5 0.0 2.6 3 0 0 3 3 3 2 Sortilin, neurotensin receptor 3, BNR_2 PF13088.6 EMD64082.1 - 0.0028 17.0 0.0 0.014 14.7 0.0 2.0 1 1 1 2 2 2 2 BNR repeat-like domain BNR PF02012.20 EMD64082.1 - 0.0072 16.1 2.4 2.3 8.6 0.2 3.4 2 0 0 2 2 2 2 BNR/Asp-box repeat Glyco_hydro_61 PF03443.14 EMD64084.1 - 3.3e-60 203.5 0.9 4.2e-60 203.2 0.9 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 UPAR_LY6 PF00021.21 EMD64085.1 - 0.05 14.3 1.4 0.055 14.2 0.3 1.6 2 0 0 2 2 2 0 u-PAR/Ly-6 domain TFR_dimer PF04253.15 EMD64086.1 - 9.9e-33 112.8 0.0 1.8e-32 112.0 0.0 1.4 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.17 EMD64086.1 - 2.7e-22 79.4 0.0 5.3e-22 78.5 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 EMD64086.1 - 2e-09 37.4 0.9 5e-09 36.1 0.2 2.0 2 0 0 2 2 2 1 PA domain Peptidase_M20 PF01546.28 EMD64086.1 - 0.037 13.7 0.1 0.27 10.9 0.1 2.1 1 1 0 1 1 1 0 Peptidase family M20/M25/M40 Nicastrin PF05450.15 EMD64086.1 - 0.051 13.0 0.3 0.1 12.0 0.0 1.5 2 0 0 2 2 2 0 Nicastrin Slx4 PF09494.10 EMD64088.1 - 2e-17 62.9 4.4 3.5e-16 58.9 4.4 2.4 1 1 0 1 1 1 1 Slx4 endonuclease Zn_clus PF00172.18 EMD64089.1 - 4.2e-07 30.0 15.5 8.8e-07 28.9 15.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FAD_binding_7 PF03441.14 EMD64090.1 - 1.9e-80 269.1 1.7 3.1e-80 268.4 1.7 1.4 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.18 EMD64090.1 - 1.2e-37 129.4 0.0 2e-37 128.7 0.0 1.3 1 0 0 1 1 1 1 DNA photolyase DUF2071 PF09844.9 EMD64090.1 - 0.064 12.9 0.1 0.43 10.2 0.0 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (COG2071) N_NLPC_P60 PF12912.7 EMD64090.1 - 0.097 13.0 1.6 0.16 12.3 0.2 2.1 2 0 0 2 2 2 0 NLPC_P60 stabilising domain, N term TFIIA PF03153.13 EMD64091.1 - 0.066 13.2 16.6 0.081 12.9 16.6 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Glyco_hydro_115 PF15979.5 EMD64092.1 - 2.6e-135 451.2 6.9 2.6e-135 451.2 6.9 1.5 2 0 0 2 2 2 1 Glycosyl hydrolase family 115 GH115_C PF17829.1 EMD64092.1 - 3e-52 176.9 0.2 1.1e-51 175.1 0.1 2.0 2 0 0 2 2 2 1 Gylcosyl hydrolase family 115 C-terminal domain Glyco_hydro_67N PF03648.14 EMD64092.1 - 0.015 15.6 0.1 0.048 13.9 0.1 1.9 1 0 0 1 1 1 0 Glycosyl hydrolase family 67 N-terminus RuBisCO_large_N PF02788.16 EMD64092.1 - 0.015 15.5 0.0 0.047 13.9 0.0 1.8 1 0 0 1 1 1 0 Ribulose bisphosphate carboxylase large chain, N-terminal domain DUF2462 PF09495.10 EMD64093.1 - 1e-15 58.2 4.1 1.1e-15 58.1 4.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2462) DUF5427 PF10310.9 EMD64094.1 - 3.1e-165 550.6 3.0 3.7e-165 550.4 3.0 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5427) D123 PF07065.14 EMD64094.1 - 0.013 14.7 1.7 0.021 14.0 1.7 1.3 1 0 0 1 1 1 0 D123 RXT2_N PF08595.11 EMD64094.1 - 0.014 15.4 2.8 0.029 14.4 2.8 1.5 1 0 0 1 1 1 0 RXT2-like, N-terminal Flu_M1_C PF08289.11 EMD64094.1 - 0.022 14.9 0.2 0.053 13.7 0.2 1.6 1 0 0 1 1 1 0 Influenza Matrix protein (M1) C-terminal domain Sigma70_ner PF04546.13 EMD64094.1 - 0.051 13.5 5.8 0.079 12.8 4.2 2.1 2 0 0 2 2 2 0 Sigma-70, non-essential region GP67 PF17634.2 EMD64094.1 - 0.063 13.7 17.6 0.14 12.6 17.6 1.5 1 0 0 1 1 1 0 Gene product 67 Nop14 PF04147.12 EMD64094.1 - 0.21 9.7 6.2 0.4 8.8 6.2 1.4 1 0 0 1 1 1 0 Nop14-like family GCIP PF13324.6 EMD64094.1 - 0.28 10.7 2.3 0.54 9.8 2.1 1.6 2 0 0 2 2 2 0 Grap2 and cyclin-D-interacting NOA36 PF06524.12 EMD64094.1 - 0.32 10.3 15.7 0.51 9.6 15.7 1.2 1 0 0 1 1 1 0 NOA36 protein RRN3 PF05327.11 EMD64094.1 - 0.46 9.0 3.4 0.68 8.4 3.4 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 S-antigen PF05756.11 EMD64094.1 - 0.52 10.7 2.7 1.2 9.6 2.7 1.5 1 0 0 1 1 1 0 S-antigen protein SARAF PF06682.12 EMD64094.1 - 0.69 9.5 10.7 1.5 8.4 10.7 1.5 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis DNA_pol_phi PF04931.13 EMD64094.1 - 0.7 7.9 16.2 1.2 7.1 16.2 1.3 1 0 0 1 1 1 0 DNA polymerase phi FAM176 PF14851.6 EMD64094.1 - 0.7 9.5 5.7 0.12 12.1 1.2 2.0 2 0 0 2 2 2 0 FAM176 family CENP-B_dimeris PF09026.10 EMD64094.1 - 3.1 8.2 20.0 8.3 6.9 20.0 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Cwf_Cwc_15 PF04889.12 EMD64094.1 - 3.6 7.3 16.9 0.11 12.2 9.8 2.0 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Transp_cyt_pur PF02133.15 EMD64096.1 - 1.5e-17 63.5 45.7 3.4e-17 62.3 45.7 1.6 1 1 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin DUF5453 PF17534.2 EMD64096.1 - 0.0045 17.0 1.2 0.0045 17.0 1.2 2.3 2 0 0 2 2 2 1 Family of unknown function (DUF5453) Amino_oxidase PF01593.24 EMD64097.1 - 1.3e-66 225.8 0.1 9.5e-65 219.6 0.1 2.0 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EMD64097.1 - 1.4e-12 47.7 0.0 4.2e-12 46.1 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 EMD64097.1 - 0.00033 20.0 0.2 0.004 16.5 0.2 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EMD64097.1 - 0.00094 18.5 0.0 0.0045 16.3 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EMD64097.1 - 0.0026 18.3 0.0 0.074 13.6 0.1 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EMD64097.1 - 0.0031 16.7 0.0 0.0062 15.7 0.0 1.4 1 0 0 1 1 1 1 Glucose inhibited division protein A DAO PF01266.24 EMD64097.1 - 0.0035 17.0 1.5 0.015 14.9 1.3 2.3 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 EMD64097.1 - 0.0043 16.3 0.1 0.0085 15.4 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain AlaDh_PNT_C PF01262.21 EMD64097.1 - 0.0061 15.9 0.1 0.023 14.0 0.2 1.7 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain FAD_oxidored PF12831.7 EMD64097.1 - 0.013 14.9 0.0 0.03 13.7 0.1 1.6 2 0 0 2 2 2 0 FAD dependent oxidoreductase HI0933_like PF03486.14 EMD64097.1 - 0.029 13.1 1.3 0.041 12.6 0.2 1.7 2 0 0 2 2 2 0 HI0933-like protein Thi4 PF01946.17 EMD64097.1 - 0.029 13.6 0.1 0.051 12.8 0.1 1.3 1 0 0 1 1 1 0 Thi4 family NAD_binding_9 PF13454.6 EMD64097.1 - 0.033 14.2 0.4 1.7 8.6 0.1 2.8 2 1 1 3 3 3 0 FAD-NAD(P)-binding FAD_binding_2 PF00890.24 EMD64097.1 - 0.063 12.4 1.1 0.11 11.6 1.1 1.5 1 1 0 1 1 1 0 FAD binding domain Exo_endo_phos PF03372.23 EMD64098.1 - 0.00013 21.6 0.0 0.00019 21.1 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family FtsZ_C PF12327.8 EMD64098.1 - 0.016 15.5 0.0 0.039 14.2 0.0 1.5 1 0 0 1 1 1 0 FtsZ family, C-terminal domain Peptidase_C14 PF00656.22 EMD64099.1 - 5.7e-44 150.9 0.0 7.1e-44 150.6 0.0 1.1 1 0 0 1 1 1 1 Caspase domain Hist_deacetyl PF00850.19 EMD64100.1 - 2.8e-84 283.2 0.0 5.1e-84 282.4 0.0 1.4 2 0 0 2 2 2 1 Histone deacetylase domain JAB PF01398.21 EMD64101.1 - 4.8e-33 113.6 0.0 8.3e-33 112.9 0.0 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 EMD64101.1 - 1.4e-12 48.0 0.3 2.9e-12 47.0 0.3 1.5 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function Prok-JAB PF14464.6 EMD64101.1 - 3.4e-08 33.3 0.0 6.4e-08 32.4 0.0 1.5 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain UPF0172 PF03665.13 EMD64101.1 - 0.054 13.5 0.0 0.27 11.2 0.0 2.0 1 1 0 2 2 2 0 Uncharacterised protein family (UPF0172) ABC_membrane PF00664.23 EMD64102.1 - 8e-35 120.8 5.5 8e-35 120.8 5.5 2.0 2 0 0 2 2 2 1 ABC transporter transmembrane region ABC_tran PF00005.27 EMD64102.1 - 2.9e-32 112.0 0.0 6.7e-32 110.9 0.0 1.6 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 EMD64102.1 - 7.8e-07 28.7 0.0 2.5e-06 27.1 0.0 1.8 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.6 EMD64102.1 - 0.013 15.7 0.2 0.22 11.8 0.2 2.7 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit RsgA_GTPase PF03193.16 EMD64102.1 - 0.032 14.1 0.0 0.096 12.6 0.0 1.7 1 0 0 1 1 1 0 RsgA GTPase AAA_29 PF13555.6 EMD64102.1 - 0.1 12.4 0.1 0.26 11.1 0.1 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_15 PF13175.6 EMD64102.1 - 0.16 11.6 0.0 0.27 10.9 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain WD40 PF00400.32 EMD64103.1 - 7.9e-11 42.4 18.1 2.3e-07 31.4 0.6 5.3 6 0 0 6 6 6 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD64103.1 - 3.8e-07 30.3 0.1 0.018 15.3 0.0 4.0 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EMD64103.1 - 8.8e-07 29.0 0.0 0.0059 16.5 0.0 2.4 2 0 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A Zn_ribbon_17 PF17120.5 EMD64103.1 - 8e-05 22.2 8.5 0.00022 20.8 8.5 1.7 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type INTAP PF16617.5 EMD64103.1 - 5.2 7.5 8.6 0.44 10.9 2.0 2.7 3 0 0 3 3 3 0 Intersectin and clathrin adaptor AP2 binding region Ribosomal_S21e PF01249.18 EMD64105.1 - 3e-40 136.2 0.0 3.4e-40 136.0 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S21e Glyco_hydro_7 PF00840.20 EMD64106.1 - 6.1e-131 437.1 7.2 7e-131 436.9 7.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 7 Ribosomal_L14 PF00238.19 EMD64107.1 - 3.6e-33 114.3 0.0 4.3e-33 114.0 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e GMC_oxred_N PF00732.19 EMD64109.1 - 7.3e-65 219.2 0.1 1.5e-64 218.2 0.0 1.5 2 0 0 2 2 2 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EMD64109.1 - 3.1e-34 118.5 0.3 7e-34 117.4 0.3 1.6 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.24 EMD64109.1 - 4.4e-09 35.9 0.0 0.0012 18.0 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.24 EMD64109.1 - 7.2e-07 29.1 0.0 0.002 17.8 0.0 3.2 3 1 0 3 3 3 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EMD64109.1 - 0.00098 19.3 0.0 0.0025 18.0 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 EMD64109.1 - 0.0012 18.0 0.0 0.0021 17.2 0.0 1.5 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_2 PF07992.14 EMD64109.1 - 0.0015 17.8 0.4 0.58 9.3 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EMD64109.1 - 0.0016 17.7 0.7 0.0038 16.5 0.1 1.8 2 0 0 2 2 2 1 Thi4 family TrkA_N PF02254.18 EMD64109.1 - 0.013 15.7 0.2 1.5 9.1 0.0 2.5 2 0 0 2 2 2 0 TrkA-N domain Pyr_redox PF00070.27 EMD64109.1 - 0.047 14.3 0.1 4.8 7.8 0.0 3.3 4 0 0 4 4 3 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EMD64109.1 - 0.16 10.6 0.1 0.35 9.5 0.0 1.6 2 0 0 2 2 2 0 HI0933-like protein ZirS_C PF16583.5 EMD64110.1 - 0.14 11.7 0.1 0.26 10.9 0.1 1.3 1 0 0 1 1 1 0 Zinc-regulated secreted antivirulence protein C-terminal domain Organ_specific PF10950.8 EMD64110.1 - 0.14 12.8 0.2 0.36 11.5 0.2 1.7 1 0 0 1 1 1 0 Organ specific protein ENTH PF01417.20 EMD64111.1 - 4.3e-47 159.2 0.5 6e-47 158.8 0.5 1.2 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.16 EMD64111.1 - 0.00088 18.3 0.1 0.0013 17.8 0.1 1.2 1 0 0 1 1 1 1 ANTH domain DUF5102 PF17104.5 EMD64111.1 - 0.1 12.6 10.7 0.09 12.8 2.2 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF5102) Pro_isomerase PF00160.21 EMD64112.1 - 6.1e-42 143.6 0.1 8.1e-42 143.2 0.1 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Cys_Met_Meta_PP PF01053.20 EMD64113.1 - 1.2e-62 211.6 0.0 3.8e-62 210.0 0.0 1.8 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 EMD64113.1 - 0.0013 17.8 0.0 0.002 17.2 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Lamprin PF06403.11 EMD64114.1 - 0.037 14.0 1.6 0.061 13.3 1.6 1.5 1 1 0 1 1 1 0 Lamprin DUF3180 PF11377.8 EMD64115.1 - 0.29 11.3 6.1 0.94 9.6 0.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3180) Integrase_H2C2 PF17921.1 EMD64117.1 - 0.043 13.9 0.0 0.048 13.8 0.0 1.1 1 0 0 1 1 1 0 Integrase zinc binding domain DUF4939 PF16297.5 EMD64119.1 - 0.1 12.4 0.0 0.12 12.3 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4939) zf-CCHC PF00098.23 EMD64120.1 - 2.6e-06 27.2 1.2 4e-06 26.7 1.2 1.3 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_2 PF13696.6 EMD64120.1 - 0.00012 21.8 0.8 0.00018 21.2 0.8 1.3 1 0 0 1 1 1 1 Zinc knuckle MauJ PF17419.2 EMD64120.1 - 0.053 13.0 0.0 0.066 12.7 0.0 1.1 1 0 0 1 1 1 0 Methylamine utilization protein MauJ zf-CCHC_5 PF14787.6 EMD64120.1 - 0.1 12.4 1.5 0.18 11.5 1.5 1.4 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger RVP_2 PF08284.11 EMD64121.1 - 0.057 13.2 0.0 0.059 13.1 0.0 1.1 1 0 0 1 1 1 0 Retroviral aspartyl protease HTH_37 PF13744.6 EMD64122.1 - 0.0012 18.8 0.1 0.0016 18.4 0.1 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain G-gamma PF00631.22 EMD64122.1 - 0.034 14.2 0.7 0.048 13.7 0.7 1.2 1 0 0 1 1 1 0 GGL domain Zn_clus PF00172.18 EMD64123.1 - 0.37 11.0 6.5 1.1 9.5 6.5 1.8 1 1 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF1289 PF06945.13 EMD64123.1 - 0.45 10.4 4.6 1.6 8.6 4.6 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1289) Sulf_transp PF04143.14 EMD64125.1 - 9.9e-08 31.9 12.0 1.1e-06 28.5 2.5 2.9 3 0 0 3 3 3 2 Sulphur transport Diphthamide_syn PF01866.17 EMD64126.1 - 5.2e-110 367.6 0.0 6.7e-110 367.3 0.0 1.1 1 0 0 1 1 1 1 Putative diphthamide synthesis protein MgsA_C PF12002.8 EMD64127.1 - 1.4e-60 204.0 1.1 2.6e-60 203.1 0.1 1.8 2 0 0 2 2 2 1 MgsA AAA+ ATPase C terminal AAA_assoc_2 PF16193.5 EMD64127.1 - 1e-20 73.8 0.1 3e-20 72.3 0.1 1.8 1 0 0 1 1 1 1 AAA C-terminal domain AAA PF00004.29 EMD64127.1 - 3.6e-15 56.6 0.1 1e-14 55.1 0.1 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EMD64127.1 - 3.1e-08 33.5 0.0 6.1e-08 32.6 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EMD64127.1 - 8.7e-06 26.2 5.1 8.4e-05 23.0 1.3 3.4 2 1 1 3 3 2 1 AAA ATPase domain AAA_5 PF07728.14 EMD64127.1 - 2.8e-05 24.1 0.0 5.7e-05 23.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EMD64127.1 - 7.9e-05 22.9 0.0 0.00024 21.4 0.0 1.9 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 EMD64127.1 - 8.1e-05 22.1 0.1 0.12 11.8 0.0 2.3 1 1 0 2 2 2 2 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 EMD64127.1 - 0.00046 19.9 0.0 0.0052 16.5 0.0 2.1 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_3 PF07726.11 EMD64127.1 - 0.0014 18.5 0.0 0.0042 16.9 0.0 1.8 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DUF815 PF05673.13 EMD64127.1 - 0.0018 17.5 0.0 0.003 16.8 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_14 PF13173.6 EMD64127.1 - 0.0044 17.1 0.0 0.0088 16.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain SKI PF01202.22 EMD64127.1 - 0.012 15.7 0.0 0.026 14.7 0.0 1.5 1 0 0 1 1 1 0 Shikimate kinase ABC_tran PF00005.27 EMD64127.1 - 0.019 15.5 0.0 0.05 14.1 0.0 1.7 1 1 0 1 1 1 0 ABC transporter AAA_24 PF13479.6 EMD64127.1 - 0.028 14.2 0.0 0.048 13.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain ResIII PF04851.15 EMD64127.1 - 0.033 14.2 0.2 1.2 9.2 0.0 2.2 1 1 1 2 2 2 0 Type III restriction enzyme, res subunit Zeta_toxin PF06414.12 EMD64127.1 - 0.061 12.6 0.0 0.16 11.2 0.0 1.7 1 0 0 1 1 1 0 Zeta toxin ATPase_2 PF01637.18 EMD64127.1 - 0.076 12.9 0.0 5 7.0 0.0 2.7 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea TniB PF05621.11 EMD64127.1 - 0.08 12.3 0.0 0.19 11.1 0.0 1.6 1 0 0 1 1 1 0 Bacterial TniB protein AAA_18 PF13238.6 EMD64127.1 - 0.085 13.4 0.0 0.19 12.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 EMD64127.1 - 0.11 11.7 0.0 0.43 9.7 0.0 1.9 2 0 0 2 2 2 0 NB-ARC domain TIP49 PF06068.13 EMD64127.1 - 0.12 11.5 0.0 0.19 10.9 0.0 1.2 1 0 0 1 1 1 0 TIP49 P-loop domain TsaE PF02367.17 EMD64127.1 - 0.15 12.1 0.0 0.29 11.1 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Sigma54_activ_2 PF14532.6 EMD64127.1 - 0.16 12.1 0.0 0.48 10.5 0.0 1.8 1 0 0 1 1 1 0 Sigma-54 interaction domain RNA_helicase PF00910.22 EMD64127.1 - 0.16 12.4 0.0 0.35 11.3 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_13 PF13166.6 EMD64127.1 - 0.2 10.2 0.0 0.31 9.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 EMD64127.1 - 0.21 11.3 1.8 0.4 10.4 0.1 2.3 2 1 0 2 2 1 0 AAA domain Rubella_E2 PF05749.11 EMD64127.1 - 0.78 9.2 6.0 1.5 8.2 6.0 1.4 1 0 0 1 1 1 0 Rubella membrane glycoprotein E2 NUDE_C PF04880.13 EMD64127.1 - 1.8 9.0 8.2 50 4.3 7.3 2.4 2 0 0 2 2 2 0 NUDE protein, C-terminal conserved region DUF3439 PF11921.8 EMD64127.1 - 1.8 8.6 8.7 4.3 7.3 8.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Aminotran_1_2 PF00155.21 EMD64128.1 - 5e-71 239.8 0.0 5.7e-71 239.6 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 EMD64128.1 - 1.3e-05 24.7 0.0 2.5e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.21 EMD64128.1 - 0.00042 19.7 0.0 0.00061 19.2 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.20 EMD64128.1 - 0.0014 17.2 0.0 0.0039 15.8 0.0 1.6 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 EMD64128.1 - 0.0057 15.6 0.0 0.011 14.7 0.0 1.5 1 1 0 1 1 1 1 Aminotransferase class-V GDI PF00996.18 EMD64129.1 - 1.6e-26 92.8 0.0 1.5e-25 89.7 0.0 2.0 1 1 0 1 1 1 1 GDP dissociation inhibitor Amidohydro_1 PF01979.20 EMD64130.1 - 1.7e-08 34.2 0.2 3.8e-08 33.0 0.0 1.7 2 0 0 2 2 2 1 Amidohydrolase family Amidohydro_3 PF07969.11 EMD64130.1 - 8.6e-08 32.1 0.2 0.00026 20.6 0.0 2.6 3 0 0 3 3 3 2 Amidohydrolase family C2 PF00168.30 EMD64131.1 - 1.9e-29 102.0 0.0 9.7e-17 61.1 0.0 3.0 3 0 0 3 3 3 2 C2 domain Ribonuclease_3 PF00636.26 EMD64133.1 - 2.2e-41 140.7 0.0 3.3e-22 79.1 0.0 2.6 2 0 0 2 2 2 2 Ribonuclease III domain Dicer_dimer PF03368.14 EMD64133.1 - 1.7e-23 82.6 0.0 4.3e-23 81.3 0.0 1.8 1 0 0 1 1 1 1 Dicer dimerisation domain Ribonucleas_3_3 PF14622.6 EMD64133.1 - 2.2e-23 82.8 0.2 4.3e-11 43.1 0.0 4.0 2 2 0 3 3 3 3 Ribonuclease-III-like DEAD PF00270.29 EMD64133.1 - 1.1e-16 61.1 0.0 2.3e-16 60.0 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EMD64133.1 - 1.1e-13 51.5 0.0 3.3e-13 49.9 0.0 1.9 1 1 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EMD64133.1 - 1.8e-13 50.9 0.0 3.9e-13 49.8 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Mon1 PF03164.14 EMD64133.1 - 0.052 12.6 2.4 0.049 12.7 0.2 1.9 2 0 0 2 2 2 0 Trafficking protein Mon1 DUF2987 PF11205.8 EMD64133.1 - 0.081 12.8 0.3 0.22 11.5 0.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2987) Proteasome PF00227.26 EMD64134.1 - 2.6e-56 190.1 0.0 3.8e-32 111.3 0.0 2.2 2 0 0 2 2 2 2 Proteasome subunit Proteasome_A_N PF10584.9 EMD64134.1 - 9.2e-11 41.2 0.1 3.1e-10 39.5 0.0 1.9 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature Peptidase_S13 PF02113.15 EMD64134.1 - 0.0081 14.9 0.5 1.6 7.3 0.0 2.2 2 0 0 2 2 2 2 D-Ala-D-Ala carboxypeptidase 3 (S13) family RINGv PF12906.7 EMD64135.1 - 9e-10 38.5 3.7 4.6e-09 36.2 1.2 2.2 2 0 0 2 2 2 1 RING-variant domain zf-BED PF02892.15 EMD64135.1 - 0.078 13.0 2.0 0.14 12.2 0.3 2.1 2 0 0 2 2 2 0 BED zinc finger zf-RING_2 PF13639.6 EMD64135.1 - 0.083 13.2 4.1 2.3 8.6 1.2 2.2 2 0 0 2 2 2 0 Ring finger domain PHD PF00628.29 EMD64135.1 - 0.6 10.1 5.1 0.29 11.1 2.3 1.8 2 0 0 2 2 2 0 PHD-finger PHD_4 PF16866.5 EMD64135.1 - 1.1 9.4 6.3 2.3 8.4 2.6 2.3 1 1 0 2 2 2 0 PHD-finger GAS2 PF02187.17 EMD64136.1 - 4.1e-06 26.8 0.1 8.9e-06 25.7 0.1 1.5 1 0 0 1 1 1 1 Growth-Arrest-Specific Protein 2 Domain TFR_dimer PF04253.15 EMD64138.1 - 1.4e-23 83.3 0.0 2.5e-23 82.5 0.0 1.4 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.17 EMD64138.1 - 4.7e-22 78.7 0.0 8.5e-22 77.8 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 EMD64138.1 - 4.9e-08 32.9 0.8 8.9e-08 32.1 0.1 1.8 2 0 0 2 2 2 1 PA domain Peptidase_M20 PF01546.28 EMD64138.1 - 0.079 12.6 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 Peptidase family M20/M25/M40 CFEM PF05730.11 EMD64139.1 - 2.9e-11 43.3 7.3 5.8e-11 42.3 7.3 1.5 1 0 0 1 1 1 1 CFEM domain JTB PF05439.12 EMD64139.1 - 2.9 8.0 5.7 3 7.9 1.9 2.3 2 1 0 2 2 2 0 Jumping translocation breakpoint protein (JTB) MFS_1 PF07690.16 EMD64140.1 - 2.1e-17 63.1 60.2 7.8e-17 61.2 55.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Gly-zipper_YMGG PF13441.6 EMD64140.1 - 1.7 8.5 7.7 8.4 6.2 0.1 2.8 2 0 0 2 2 2 0 YMGG-like Gly-zipper p450 PF00067.22 EMD64141.1 - 1.8e-43 149.0 0.3 8.5e-43 146.8 0.1 1.8 1 1 1 2 2 2 1 Cytochrome P450 TED_complement PF07678.14 EMD64141.1 - 0.084 11.9 0.1 0.12 11.3 0.1 1.2 1 0 0 1 1 1 0 A-macroglobulin TED domain UvrD-helicase PF00580.21 EMD64141.1 - 0.087 12.3 0.1 0.11 12.0 0.1 1.2 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain LtrA PF06772.11 EMD64142.1 - 3.3e-25 89.1 18.1 3.3e-25 89.1 18.1 2.0 2 0 0 2 2 2 1 Bacterial low temperature requirement A protein (LtrA) DUF4131 PF13567.6 EMD64142.1 - 0.88 9.2 0.0 0.88 9.2 0.0 4.2 3 1 2 5 5 5 0 Domain of unknown function (DUF4131) MFS_1 PF07690.16 EMD64143.1 - 1.4e-35 122.9 9.2 1.4e-35 122.9 9.2 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EMD64143.1 - 3.8e-14 52.4 4.3 3.8e-14 52.4 4.3 2.1 2 0 0 2 2 2 1 Sugar (and other) transporter MFS_1_like PF12832.7 EMD64143.1 - 1.2e-06 27.7 3.0 1.2e-06 27.7 3.0 2.6 3 0 0 3 3 3 1 MFS_1 like family MFS_2 PF13347.6 EMD64143.1 - 0.00018 20.2 11.1 0.0018 16.9 1.5 2.8 2 1 1 3 3 3 2 MFS/sugar transport protein MFS_4 PF06779.14 EMD64143.1 - 0.00026 20.4 0.5 0.00026 20.4 0.5 2.8 3 0 0 3 3 3 1 Uncharacterised MFS-type transporter YbfB Folate_carrier PF01770.18 EMD64143.1 - 0.0011 17.8 0.0 0.002 17.0 0.0 1.3 1 0 0 1 1 1 1 Reduced folate carrier TRI12 PF06609.13 EMD64143.1 - 0.013 13.9 0.7 0.025 13.0 0.7 1.4 1 0 0 1 1 1 0 Fungal trichothecene efflux pump (TRI12) DJ-1_PfpI PF01965.24 EMD64144.1 - 1.4e-13 51.0 0.0 1.7e-13 50.7 0.0 1.2 1 0 0 1 1 1 1 DJ-1/PfpI family RGS PF00615.19 EMD64146.1 - 2.3e-06 27.9 0.0 0.00026 21.2 0.0 2.3 2 0 0 2 2 2 2 Regulator of G protein signaling domain NAD_binding_8 PF13450.6 EMD64148.1 - 9.2e-13 48.2 0.0 2e-12 47.2 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 EMD64148.1 - 5.1e-11 42.5 0.1 1.1e-09 38.2 0.0 2.6 2 1 0 2 2 2 1 Flavin containing amine oxidoreductase Pyr_redox_2 PF07992.14 EMD64148.1 - 0.00012 21.4 0.0 0.0053 16.0 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EMD64148.1 - 0.00016 21.4 0.0 0.00085 19.0 0.0 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EMD64148.1 - 0.00023 21.2 0.0 0.027 14.5 0.0 2.3 2 0 0 2 2 2 1 FAD-NAD(P)-binding FMO-like PF00743.19 EMD64148.1 - 0.0015 17.1 0.0 0.0022 16.5 0.0 1.2 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like FAD_binding_2 PF00890.24 EMD64148.1 - 0.0019 17.4 0.0 0.0028 16.8 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.27 EMD64148.1 - 0.0092 16.5 0.0 0.03 14.9 0.0 1.9 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase MCRA PF06100.11 EMD64148.1 - 0.031 13.1 0.0 0.042 12.6 0.0 1.1 1 0 0 1 1 1 0 MCRA family HI0933_like PF03486.14 EMD64148.1 - 0.17 10.5 0.0 0.27 9.9 0.0 1.2 1 0 0 1 1 1 0 HI0933-like protein V-SNARE PF05008.15 EMD64149.1 - 4.7e-21 74.9 4.2 4.7e-21 74.9 4.2 1.8 2 0 0 2 2 2 1 Vesicle transport v-SNARE protein N-terminus V-SNARE_C PF12352.8 EMD64149.1 - 4.1e-18 65.4 7.4 4.1e-18 65.4 7.4 2.9 5 0 0 5 5 5 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 EMD64149.1 - 0.0096 15.8 0.3 0.0096 15.8 0.3 2.5 2 1 0 2 2 2 1 Sec20 Fusion_gly PF00523.18 EMD64149.1 - 0.041 12.1 2.5 0.071 11.4 0.9 2.2 2 1 1 3 3 3 0 Fusion glycoprotein F0 DUF1542 PF07564.11 EMD64149.1 - 0.05 13.7 0.6 0.1 12.7 0.6 1.5 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1542) Prominin PF05478.11 EMD64149.1 - 0.13 10.2 2.8 2.5 6.0 0.1 2.0 2 0 0 2 2 2 0 Prominin Synaptobrevin PF00957.21 EMD64149.1 - 0.17 11.7 0.1 0.17 11.7 0.1 2.7 3 0 0 3 3 3 0 Synaptobrevin Use1 PF09753.9 EMD64149.1 - 0.19 11.4 8.9 15 5.2 8.9 2.4 1 1 0 1 1 1 0 Membrane fusion protein Use1 YqjK PF13997.6 EMD64149.1 - 0.56 10.5 0.1 0.56 10.5 0.1 2.7 3 0 0 3 3 3 0 YqjK-like protein V-ATPase_G_2 PF16999.5 EMD64149.1 - 1.8 9.0 8.5 0.16 12.4 3.3 1.9 2 1 0 2 2 2 0 Vacuolar (H+)-ATPase G subunit Exonuc_VII_L PF02601.15 EMD64149.1 - 2.2 7.7 12.2 12 5.3 12.2 1.9 1 1 0 1 1 1 0 Exonuclease VII, large subunit Fungal_trans PF04082.18 EMD64151.1 - 5.2e-26 91.3 0.0 8.9e-26 90.5 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Il2rg PF15874.5 EMD64151.1 - 0.12 12.6 0.1 0.85 9.9 0.0 2.2 2 0 0 2 2 2 0 Putative Interleukin 2 receptor, gamma chain p450 PF00067.22 EMD64152.1 - 3.8e-43 147.9 0.0 1.8e-25 89.6 0.0 2.0 2 0 0 2 2 2 2 Cytochrome P450 Hydrolase_4 PF12146.8 EMD64153.1 - 1.7e-05 24.2 0.1 0.059 12.6 0.1 2.2 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 EMD64153.1 - 2.1e-05 24.1 0.0 0.0087 15.6 0.1 2.2 1 1 1 2 2 2 2 Prolyl oligopeptidase family DLH PF01738.18 EMD64153.1 - 0.00023 20.8 0.0 0.00033 20.3 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_1 PF00561.20 EMD64153.1 - 0.0013 18.4 0.0 0.0026 17.4 0.0 1.6 1 1 1 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.7 EMD64153.1 - 0.0046 16.7 0.0 0.0059 16.4 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.7 EMD64153.1 - 0.005 17.5 4.7 0.012 16.2 4.6 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family DUF915 PF06028.11 EMD64153.1 - 0.01 15.2 0.0 0.019 14.3 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF915) Abhydrolase_2 PF02230.16 EMD64153.1 - 0.081 12.7 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase NUC173 PF08161.12 EMD64154.1 - 5.4e-82 274.4 0.2 1.2e-76 257.0 0.0 3.2 3 0 0 3 3 3 2 NUC173 domain HEAT_2 PF13646.6 EMD64154.1 - 0.029 14.8 0.9 6.8 7.2 0.2 4.1 3 1 0 3 3 3 0 HEAT repeats HEAT PF02985.22 EMD64154.1 - 0.093 13.0 0.1 87 3.8 0.0 3.8 3 0 0 3 3 3 0 HEAT repeat VSG_B PF13206.6 EMD64154.1 - 0.13 11.5 10.6 0.065 12.5 3.8 2.6 2 0 0 2 2 2 0 Trypanosomal VSG domain TFCD_C PF12612.8 EMD64154.1 - 1.1 9.0 4.7 10 5.9 0.1 4.2 5 0 0 5 5 5 0 Tubulin folding cofactor D C terminal DOCK_N PF16172.5 EMD64155.1 - 1e-109 366.9 0.0 1.9e-109 366.1 0.0 1.5 1 0 0 1 1 1 1 DOCK N-terminus DHR-2 PF06920.13 EMD64155.1 - 1.6e-38 132.6 1.9 7e-38 130.6 1.9 1.8 1 1 0 1 1 1 1 Dock homology region 2 DOCK-C2 PF14429.6 EMD64155.1 - 3.2e-35 121.7 0.0 1.7e-34 119.4 0.0 2.2 2 0 0 2 2 2 1 C2 domain in Dock180 and Zizimin proteins SH3_1 PF00018.28 EMD64155.1 - 0.0015 18.1 0.0 0.0032 17.0 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EMD64155.1 - 0.0049 16.7 0.1 0.016 15.1 0.0 1.9 2 0 0 2 2 2 1 Variant SH3 domain Ribosomal_L30 PF00327.20 EMD64157.1 - 5.2e-14 51.9 0.2 6.6e-14 51.5 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e SART-1 PF03343.13 EMD64158.1 - 4.7e-175 583.8 75.9 5.4e-175 583.6 75.9 1.0 1 0 0 1 1 1 1 SART-1 family CH_2 PF06294.11 EMD64158.1 - 0.032 14.4 1.9 0.14 12.3 0.6 2.4 2 0 0 2 2 2 0 CH-like domain in sperm protein KptA_kDCL PF18176.1 EMD64158.1 - 0.095 12.6 2.6 0.24 11.3 0.4 2.4 2 0 0 2 2 2 0 KptA in kinetoplastid DICER domain PCYCGC PF13798.6 EMD64158.1 - 0.13 12.1 0.2 0.44 10.4 0.2 1.9 1 0 0 1 1 1 0 Protein of unknown function with PCYCGC motif DUF2650 PF10853.8 EMD64159.1 - 0.063 13.0 0.2 0.15 11.8 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2650) L51_S25_CI-B8 PF05047.16 EMD64160.1 - 1.1e-16 60.5 0.0 1.6e-16 59.9 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain SRA1 PF07304.11 EMD64161.1 - 1.3e-11 44.5 2.7 1.3e-11 44.5 2.7 3.1 2 2 1 3 3 3 1 Steroid receptor RNA activator (SRA1) Sec16_C PF12931.7 EMD64161.1 - 0.00077 19.2 0.7 0.0037 17.0 0.7 2.0 1 1 0 1 1 1 1 Sec23-binding domain of Sec16 WD40 PF00400.32 EMD64161.1 - 0.0035 18.2 1.6 7.4 7.6 0.0 5.3 6 0 0 6 6 6 1 WD domain, G-beta repeat Prp18 PF02840.15 EMD64161.1 - 0.043 13.9 0.4 0.043 13.9 0.4 2.4 2 1 0 2 2 2 0 Prp18 domain RRM_1 PF00076.22 EMD64162.1 - 9e-17 60.7 0.0 1.4e-16 60.1 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EMD64162.1 - 0.00013 22.0 0.0 0.00018 21.5 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif RRM_5 PF13893.6 EMD64162.1 - 0.016 14.8 0.0 0.04 13.5 0.0 1.6 1 1 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) LD_cluster3 PF18180.1 EMD64162.1 - 0.039 13.6 0.0 0.06 13.0 0.0 1.2 1 0 0 1 1 1 0 SLOG cluster3 family B12D PF06522.11 EMD64163.1 - 0.0011 18.7 0.0 0.0023 17.7 0.0 1.7 1 0 0 1 1 1 1 NADH-ubiquinone reductase complex 1 MLRQ subunit COX6B PF02297.17 EMD64164.1 - 2.6e-19 69.2 4.8 3e-19 69.0 4.8 1.1 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb CX9C PF16860.5 EMD64164.1 - 0.0029 17.6 2.2 0.0046 16.9 2.2 1.3 1 0 0 1 1 1 1 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, APOBEC_C PF05240.14 EMD64164.1 - 0.006 16.5 0.2 0.0079 16.1 0.2 1.2 1 0 0 1 1 1 1 APOBEC-like C-terminal domain DnaJ PF00226.31 EMD64165.1 - 7.5e-10 38.8 0.7 3.1e-09 36.8 0.7 2.0 1 1 0 1 1 1 1 DnaJ domain POP1 PF06978.11 EMD64166.1 - 4.6e-66 222.7 13.3 4.6e-66 222.7 13.3 3.1 3 0 0 3 3 3 1 Ribonucleases P/MRP protein subunit POP1 POPLD PF08170.12 EMD64166.1 - 2.2e-31 108.1 1.5 2.2e-31 108.1 1.5 2.9 3 0 0 3 3 3 1 POPLD (NUC188) domain Sgf11 PF08209.11 EMD64166.1 - 1.6e-13 50.0 1.7 1.7e-13 49.8 0.1 1.9 2 0 0 2 2 2 1 Sgf11 (transcriptional regulation protein) GCV_T PF01571.21 EMD64166.1 - 0.043 13.2 0.0 7.2 5.9 0.0 2.3 2 0 0 2 2 2 0 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.11 EMD64166.1 - 0.19 11.7 0.0 3.2 7.8 0.0 2.3 2 0 0 2 2 2 0 Glycine cleavage T-protein C-terminal barrel domain zf-C2HC_2 PF13913.6 EMD64166.1 - 8.2 6.5 8.6 0.88 9.6 1.2 2.4 2 0 0 2 2 2 0 zinc-finger of a C2HC-type TPR_1 PF00515.28 EMD64169.1 - 7.7e-57 186.9 24.2 1.1e-08 34.5 0.0 10.8 11 1 0 11 11 10 9 Tetratricopeptide repeat TPR_2 PF07719.17 EMD64169.1 - 3.8e-48 157.8 18.4 4.1e-06 26.5 0.0 10.5 11 0 0 11 11 10 8 Tetratricopeptide repeat TPR_8 PF13181.6 EMD64169.1 - 6.4e-40 132.0 17.7 6e-06 26.1 0.0 10.7 10 1 0 10 10 10 8 Tetratricopeptide repeat TPR_17 PF13431.6 EMD64169.1 - 7.7e-31 104.3 15.9 2e-05 24.7 0.1 10.2 11 0 0 11 11 10 6 Tetratricopeptide repeat TPR_11 PF13414.6 EMD64169.1 - 5.4e-28 96.4 23.2 1e-06 28.3 1.0 9.7 5 2 4 9 9 9 6 TPR repeat TPR_16 PF13432.6 EMD64169.1 - 7.8e-25 87.3 12.0 2.9e-07 31.0 0.1 7.3 6 1 2 8 8 7 4 Tetratricopeptide repeat TPR_19 PF14559.6 EMD64169.1 - 1.8e-24 86.0 10.2 0.00059 20.3 0.9 7.4 4 2 3 7 7 7 5 Tetratricopeptide repeat TPR_14 PF13428.6 EMD64169.1 - 1.1e-23 81.8 13.4 3.5e-05 24.3 0.1 8.9 5 2 5 10 10 9 6 Tetratricopeptide repeat TPR_7 PF13176.6 EMD64169.1 - 3.5e-22 76.8 13.1 0.0096 15.9 0.1 9.0 9 1 0 9 9 8 4 Tetratricopeptide repeat TPR_12 PF13424.6 EMD64169.1 - 3.3e-21 75.4 19.2 2.6e-05 24.4 0.6 7.6 4 2 2 6 6 6 5 Tetratricopeptide repeat TPR_6 PF13174.6 EMD64169.1 - 2.7e-20 71.6 21.2 0.0038 17.8 0.0 9.4 10 0 0 10 10 9 4 Tetratricopeptide repeat TPR_9 PF13371.6 EMD64169.1 - 1e-15 57.6 9.8 0.00068 19.7 0.1 6.4 1 1 7 8 8 8 8 Tetratricopeptide repeat TPR_15 PF13429.6 EMD64169.1 - 1.4e-11 44.1 8.1 0.018 14.3 0.1 5.1 1 1 3 5 5 5 5 Tetratricopeptide repeat ANAPC3 PF12895.7 EMD64169.1 - 5.9e-09 36.0 12.5 4e-08 33.4 2.9 3.6 4 0 0 4 4 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_21 PF09976.9 EMD64169.1 - 2.1e-06 27.6 4.5 1.1 8.9 0.0 4.5 4 2 0 4 4 4 3 Tetratricopeptide repeat-like domain BTAD PF03704.17 EMD64169.1 - 1.1e-05 25.9 5.1 0.34 11.3 0.0 3.5 3 0 0 3 3 3 2 Bacterial transcriptional activator domain DUF2225 PF09986.9 EMD64169.1 - 0.0041 16.9 1.9 0.19 11.4 0.0 2.9 2 2 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2225) TPR_MalT PF17874.1 EMD64169.1 - 0.0079 15.6 3.2 0.44 9.9 0.1 3.0 2 2 0 2 2 2 1 MalT-like TPR region ChAPs PF09295.10 EMD64169.1 - 0.18 10.8 1.5 8.1 5.3 0.2 2.9 2 1 0 3 3 3 0 ChAPs (Chs5p-Arf1p-binding proteins) TPR_20 PF14561.6 EMD64169.1 - 0.35 11.2 0.1 0.35 11.2 0.1 4.0 5 1 1 6 6 4 0 Tetratricopeptide repeat TPR_10 PF13374.6 EMD64169.1 - 0.7 9.8 20.8 5.6 7.0 0.0 7.3 9 0 0 9 9 9 0 Tetratricopeptide repeat SNAP PF14938.6 EMD64169.1 - 0.9 8.9 18.3 8 5.8 0.6 5.0 1 1 3 4 4 4 0 Soluble NSF attachment protein, SNAP MIT PF04212.18 EMD64169.1 - 5.3 7.2 25.8 4.6 7.4 0.0 6.6 7 1 1 8 8 6 0 MIT (microtubule interacting and transport) domain NuiA PF07924.11 EMD64170.1 - 1.6e-07 31.8 0.9 0.00065 20.1 0.0 2.4 1 1 1 2 2 2 2 Nuclease A inhibitor-like protein SKN1 PF03935.15 EMD64172.1 - 1.2e-231 769.4 0.3 1.4e-231 769.2 0.3 1.0 1 0 0 1 1 1 1 Beta-glucan synthesis-associated protein (SKN1) CbiA PF01656.23 EMD64173.1 - 0.076 13.1 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain p450 PF00067.22 EMD64174.1 - 5.1e-41 140.9 0.0 7.2e-41 140.4 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 DJ-1_PfpI PF01965.24 EMD64176.1 - 2.1e-41 141.5 0.1 2.5e-41 141.2 0.1 1.1 1 0 0 1 1 1 1 DJ-1/PfpI family DUF4231 PF14015.6 EMD64176.1 - 4.9e-05 23.7 0.0 8e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF4231) ThiJ_like PF17124.5 EMD64176.1 - 0.00026 20.7 0.0 0.015 15.0 0.0 2.1 1 1 1 2 2 2 1 ThiJ/PfpI family-like SLATT_3 PF18184.1 EMD64176.1 - 0.014 15.6 0.0 0.018 15.2 0.0 1.2 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain 3 Vault_3 PF17795.1 EMD64176.1 - 0.034 14.2 0.0 0.08 13.0 0.0 1.6 1 0 0 1 1 1 0 Major Vault Protein Repeat domain GATase_3 PF07685.14 EMD64176.1 - 0.055 13.1 0.0 0.072 12.7 0.0 1.3 1 0 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain GATA PF00320.27 EMD64177.1 - 3.5e-16 58.5 2.5 7.5e-16 57.5 2.5 1.6 1 0 0 1 1 1 1 GATA zinc finger DUF1752 PF08550.10 EMD64177.1 - 1.9e-12 46.8 2.4 3.5e-12 45.9 2.4 1.5 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) DASH_Hsk3 PF08227.11 EMD64181.1 - 3.5e-18 65.7 3.7 4.5e-18 65.3 3.7 1.2 1 0 0 1 1 1 1 DASH complex subunit Hsk3 like ADIP PF11559.8 EMD64181.1 - 0.022 14.8 0.0 0.027 14.6 0.0 1.0 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding SlyX PF04102.12 EMD64181.1 - 0.064 13.9 0.8 0.085 13.5 0.8 1.2 1 0 0 1 1 1 0 SlyX FAM193_C PF15914.5 EMD64182.1 - 0.0027 17.4 0.1 0.0036 17.0 0.1 1.2 1 0 0 1 1 1 1 FAM193 family C-terminal CytB6-F_Fe-S PF08802.10 EMD64182.1 - 0.16 12.0 1.0 0.16 12.0 1.0 1.8 2 0 0 2 2 2 0 Cytochrome B6-F complex Fe-S subunit Sugar_tr PF00083.24 EMD64183.1 - 2.7e-76 257.2 25.6 3.5e-76 256.9 25.6 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD64183.1 - 7.4e-27 94.2 27.1 7.4e-27 94.2 27.1 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EMD64183.1 - 1.4e-07 30.4 1.0 2.4e-07 29.6 1.0 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Abhydrolase_3 PF07859.13 EMD64184.1 - 7.1e-38 130.6 0.2 6.9e-26 91.4 0.0 2.4 1 1 0 2 2 2 2 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 EMD64184.1 - 0.015 14.2 0.0 0.025 13.5 0.0 1.3 1 0 0 1 1 1 0 Steryl acetyl hydrolase SOG2 PF10428.9 EMD64184.1 - 7.4 5.6 8.0 13 4.8 8.0 1.3 1 0 0 1 1 1 0 RAM signalling pathway protein HMG_box PF00505.19 EMD64185.1 - 6.8e-23 80.9 1.2 1.5e-22 79.8 1.2 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EMD64185.1 - 2.6e-07 31.1 0.4 5.8e-07 30.0 0.4 1.6 1 0 0 1 1 1 1 HMG-box domain SPO22 PF08631.10 EMD64186.1 - 2.8e-77 259.9 19.6 1.8e-75 254.0 5.5 4.6 3 2 1 5 5 5 3 Meiosis protein SPO22/ZIP4 like TPR_12 PF13424.6 EMD64186.1 - 4.8e-06 26.8 8.1 0.0067 16.7 0.1 4.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 EMD64186.1 - 0.0026 17.8 13.8 0.81 10.0 0.1 5.0 4 0 0 4 4 4 3 Tetratricopeptide repeat Kin17_mid PF10357.9 EMD64186.1 - 0.044 13.7 0.4 0.15 12.0 0.4 1.9 1 0 0 1 1 1 0 Domain of Kin17 curved DNA-binding protein TPR_14 PF13428.6 EMD64186.1 - 0.057 14.3 12.1 25 6.1 0.1 6.4 6 0 0 6 6 5 0 Tetratricopeptide repeat HSBP1 PF06825.12 EMD64186.1 - 0.08 12.8 0.0 0.28 11.1 0.0 2.0 1 0 0 1 1 1 0 Heat shock factor binding protein 1 GrpE PF01025.19 EMD64186.1 - 0.099 12.3 1.0 0.33 10.6 1.0 1.9 1 0 0 1 1 1 0 GrpE TPR_16 PF13432.6 EMD64186.1 - 0.13 12.9 6.9 5.5 7.7 0.2 3.5 3 0 0 3 3 2 0 Tetratricopeptide repeat Sel1 PF08238.12 EMD64186.1 - 0.28 11.9 2.8 12 6.8 0.2 2.9 2 0 0 2 2 2 0 Sel1 repeat TPR_19 PF14559.6 EMD64186.1 - 0.32 11.5 0.0 0.32 11.5 0.0 3.9 5 0 0 5 5 4 0 Tetratricopeptide repeat TFIID_NTD2 PF04494.15 EMD64186.1 - 1.1 9.5 4.3 0.69 10.2 0.7 2.6 2 1 0 2 2 2 0 WD40 associated region in TFIID subunit, NTD2 domain TPR_6 PF13174.6 EMD64186.1 - 4.1 8.2 7.5 4 8.3 0.4 4.4 4 0 0 4 4 3 0 Tetratricopeptide repeat Zn_clus PF00172.18 EMD64187.1 - 9.7e-06 25.6 8.7 1.9e-05 24.7 8.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CENP-Q PF13094.6 EMD64188.1 - 2.8e-38 131.8 5.5 2.8e-38 131.8 5.5 2.2 2 1 0 2 2 2 1 CENP-Q, a CENPA-CAD centromere complex subunit DUF3106 PF11304.8 EMD64188.1 - 0.0057 17.1 1.8 0.0057 17.1 1.8 2.3 1 1 0 2 2 2 1 Protein of unknown function (DUF3106) JIP_LZII PF16471.5 EMD64188.1 - 0.17 12.1 3.8 0.13 12.4 0.6 2.4 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II ADIP PF11559.8 EMD64188.1 - 0.24 11.5 15.1 0.074 13.1 10.1 2.6 2 1 0 2 2 2 0 Afadin- and alpha -actinin-Binding Adaptin_binding PF10199.9 EMD64188.1 - 0.74 10.4 8.7 1.4 9.6 4.1 2.4 2 1 0 2 2 2 0 Alpha and gamma adaptin binding protein p34 DUF1664 PF07889.12 EMD64188.1 - 1.1 9.3 5.0 18 5.4 0.7 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) HhH-GPD PF00730.25 EMD64190.1 - 1.4e-05 25.5 0.0 4.1e-05 24.0 0.0 1.8 1 1 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 EMD64190.1 - 0.01 15.7 0.0 0.027 14.3 0.0 1.8 1 0 0 1 1 1 0 Helix-hairpin-helix motif HHH_5 PF14520.6 EMD64190.1 - 0.035 14.7 0.8 0.74 10.5 0.0 2.9 3 0 0 3 3 3 0 Helix-hairpin-helix domain Abhydrolase_2 PF02230.16 EMD64191.1 - 2e-59 201.1 0.1 2.2e-59 200.9 0.1 1.0 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.8 EMD64191.1 - 1.1e-06 28.1 0.6 0.0038 16.5 0.0 3.0 2 1 1 3 3 3 2 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 EMD64191.1 - 3e-06 26.9 1.3 0.00016 21.3 0.1 2.6 3 0 0 3 3 3 1 Prolyl oligopeptidase family DLH PF01738.18 EMD64191.1 - 3.6e-05 23.4 0.0 5.2e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family FSH1 PF03959.13 EMD64191.1 - 7.7e-05 22.4 0.0 0.00047 19.9 0.0 2.2 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_3 PF07859.13 EMD64191.1 - 0.00012 22.1 0.3 0.3 10.9 0.1 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Lipase_3 PF01764.25 EMD64191.1 - 0.016 15.1 0.0 0.03 14.2 0.0 1.5 1 0 0 1 1 1 0 Lipase (class 3) Abhydrolase_6 PF12697.7 EMD64191.1 - 0.019 15.6 0.0 0.039 14.6 0.0 1.3 1 1 0 1 1 1 0 Alpha/beta hydrolase family Abhydrolase_5 PF12695.7 EMD64191.1 - 0.039 13.7 0.0 0.073 12.8 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family Cutinase PF01083.22 EMD64191.1 - 0.054 13.5 0.0 0.07 13.1 0.0 1.3 1 0 0 1 1 1 0 Cutinase Abhydro_lipase PF04083.16 EMD64191.1 - 0.13 11.8 0.1 8.3 6.1 0.0 2.6 3 0 0 3 3 3 0 Partial alpha/beta-hydrolase lipase region Chitin_bind_1 PF00187.19 EMD64192.1 - 2.5e-20 72.6 67.7 5.3e-11 42.8 18.6 4.1 3 2 0 3 3 3 3 Chitin recognition protein HCV_NS4b PF01001.19 EMD64193.1 - 0.023 14.3 3.9 0.028 14.0 3.9 1.0 1 0 0 1 1 1 0 Hepatitis C virus non-structural protein NS4b adh_short PF00106.25 EMD64194.1 - 1e-43 149.1 0.8 1.4e-43 148.6 0.8 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD64194.1 - 1.9e-39 135.6 0.1 2.9e-39 135.0 0.1 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD64194.1 - 6.9e-07 29.4 0.5 1.1e-06 28.7 0.1 1.6 2 0 0 2 2 2 1 KR domain Polysacc_synt_2 PF02719.15 EMD64194.1 - 9e-05 21.7 0.8 0.00017 20.8 0.8 1.4 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein ADH_zinc_N PF00107.26 EMD64194.1 - 0.003 17.5 0.1 0.01 15.8 0.2 1.9 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Shikimate_DH PF01488.20 EMD64194.1 - 0.0034 17.4 0.3 0.0064 16.6 0.3 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase ApbA PF02558.16 EMD64194.1 - 0.012 15.3 0.3 0.057 13.1 0.1 2.1 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA 3HCDH_N PF02737.18 EMD64194.1 - 0.027 14.4 1.4 0.059 13.2 0.6 1.8 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_7 PF13241.6 EMD64194.1 - 0.046 14.2 0.4 0.1 13.0 0.4 1.6 1 0 0 1 1 1 0 Putative NAD(P)-binding Pyr_redox PF00070.27 EMD64194.1 - 0.061 13.9 1.6 2.1 9.0 0.4 2.7 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Transcript_VP30 PF11507.8 EMD64195.1 - 0.023 14.8 0.0 0.055 13.5 0.0 1.6 1 0 0 1 1 1 0 Ebola virus-specific transcription factor VP30 TMCO5 PF14992.6 EMD64195.1 - 0.12 11.9 5.1 0.37 10.3 5.4 1.7 2 0 0 2 2 2 0 TMCO5 family DivIVA PF05103.13 EMD64195.1 - 0.6 10.2 3.3 0.44 10.6 0.3 2.1 2 0 0 2 2 2 0 DivIVA protein bZIP_2 PF07716.15 EMD64195.1 - 8.4 6.6 8.6 0.67 10.1 1.8 2.5 2 0 0 2 2 2 0 Basic region leucine zipper HSP70 PF00012.20 EMD64196.1 - 1.2e-12 46.9 0.0 3.2e-12 45.5 0.0 1.6 1 1 0 1 1 1 1 Hsp70 protein FtsA PF14450.6 EMD64196.1 - 0.0012 19.2 0.1 0.056 13.9 0.0 2.5 2 0 0 2 2 2 1 Cell division protein FtsA MreB_Mbl PF06723.13 EMD64196.1 - 0.03 13.2 0.0 0.056 12.2 0.0 1.4 1 0 0 1 1 1 0 MreB/Mbl protein DUF2623 PF11115.8 EMD64198.1 - 0.18 11.9 1.4 0.38 10.8 1.5 1.5 1 1 1 2 2 2 0 Protein of unknown function (DUF2623) PAXNEB PF05625.11 EMD64199.1 - 0.12 11.5 0.0 0.18 10.9 0.0 1.2 1 0 0 1 1 1 0 PAXNEB protein Zn_clus PF00172.18 EMD64200.1 - 9.6e-08 32.0 8.0 1.6e-07 31.3 8.0 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Metallophos PF00149.28 EMD64201.1 - 6.4e-11 43.1 0.1 9.9e-11 42.5 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EMD64201.1 - 1.4e-07 31.9 0.1 0.00026 21.2 0.0 2.2 2 0 0 2 2 2 2 Calcineurin-like phosphoesterase superfamily domain HLH PF00010.26 EMD64202.1 - 4.7e-15 55.3 1.0 3.1e-14 52.7 0.2 2.3 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain DivIC PF04977.15 EMD64202.1 - 0.1 12.4 1.0 0.96 9.3 0.2 2.1 2 0 0 2 2 2 0 Septum formation initiator HALZ PF02183.18 EMD64202.1 - 0.32 11.3 0.9 1.6 9.0 0.2 2.2 2 0 0 2 2 2 0 Homeobox associated leucine zipper Bromodomain PF00439.25 EMD64203.1 - 5.5e-08 32.8 0.0 3.5e-07 30.2 0.0 2.2 1 1 0 1 1 1 1 Bromodomain SlyX PF04102.12 EMD64204.1 - 0.0021 18.6 1.9 0.0043 17.6 1.9 1.6 1 1 0 1 1 1 1 SlyX Sugarporin_N PF11471.8 EMD64204.1 - 0.0034 17.3 4.6 0.0084 16.0 4.6 1.6 1 0 0 1 1 1 1 Maltoporin periplasmic N-terminal extension ATG16 PF08614.11 EMD64204.1 - 0.012 15.9 3.2 0.012 15.9 3.2 1.9 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) DASH_Spc19 PF08287.11 EMD64204.1 - 0.016 15.1 0.4 0.022 14.7 0.4 1.3 1 0 0 1 1 1 0 Spc19 SKA1 PF07160.12 EMD64204.1 - 0.024 14.5 0.5 0.028 14.3 0.5 1.1 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 ABC_tran_CTD PF16326.5 EMD64204.1 - 0.09 13.0 2.4 0.18 12.1 2.2 1.6 1 1 0 1 1 1 0 ABC transporter C-terminal domain Spc7 PF08317.11 EMD64204.1 - 0.15 10.9 1.3 0.18 10.6 1.3 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein ATP_transf PF09830.9 EMD64205.1 - 2.3e-15 56.5 0.0 3.9e-15 55.7 0.0 1.4 1 0 0 1 1 1 1 ATP adenylyltransferase Peptidase_M14 PF00246.24 EMD64206.1 - 1.1e-84 284.7 0.2 1.4e-84 284.3 0.2 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase Propep_M14 PF02244.16 EMD64206.1 - 0.12 12.8 0.1 0.75 10.2 0.0 2.2 2 0 0 2 2 2 0 Carboxypeptidase activation peptide HTH_Tnp_Tc5 PF03221.16 EMD64207.1 - 2.4e-09 37.1 0.0 4.4e-09 36.3 0.0 1.5 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EMD64207.1 - 0.00079 19.1 0.1 0.0012 18.5 0.1 1.3 1 0 0 1 1 1 1 helix-turn-helix, Psq domain TnsD PF15978.5 EMD64207.1 - 0.015 14.3 0.1 0.017 14.1 0.1 1.1 1 0 0 1 1 1 0 Tn7-like transposition protein D Ribosomal_S13_N PF08069.12 EMD64207.1 - 0.016 15.2 0.0 0.025 14.6 0.0 1.3 1 0 0 1 1 1 0 Ribosomal S13/S15 N-terminal domain Cdc6_C PF09079.11 EMD64207.1 - 0.029 14.3 0.0 4.7 7.2 0.0 2.2 2 0 0 2 2 2 0 CDC6, C terminal winged helix domain HTH_24 PF13412.6 EMD64207.1 - 0.036 13.6 0.1 0.38 10.4 0.0 2.2 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding DUF3400 PF11880.8 EMD64207.1 - 0.17 11.5 0.0 0.32 10.6 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3400) DUF2721 PF11026.8 EMD64207.1 - 0.24 11.3 1.0 0.34 10.8 1.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2721) Ferric_reduct PF01794.19 EMD64208.1 - 4.9e-19 68.7 29.4 9.2e-19 67.8 21.4 2.7 3 0 0 3 3 3 2 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 EMD64208.1 - 2.2e-13 50.6 0.0 3.2e-13 50.1 0.0 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EMD64208.1 - 2.7e-13 50.0 0.0 8.3e-13 48.4 0.0 1.9 2 0 0 2 2 2 1 FAD-binding domain NAD_binding_1 PF00175.21 EMD64208.1 - 0.0003 21.4 0.0 0.023 15.4 0.0 2.3 1 1 1 2 2 2 1 Oxidoreductase NAD-binding domain DUF4405 PF14358.6 EMD64208.1 - 3.8 8.1 22.6 0.29 11.7 3.8 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4405) Ctr PF04145.15 EMD64209.1 - 9.6e-25 87.9 7.5 4.7e-24 85.7 7.5 1.8 1 1 0 1 1 1 1 Ctr copper transporter family SMC_N PF02463.19 EMD64210.1 - 6.1e-23 81.4 0.0 1.4e-22 80.2 0.0 1.8 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EMD64210.1 - 2.2e-13 51.2 71.9 1.1e-12 48.9 23.0 5.4 2 2 0 3 3 3 1 AAA domain AAA_15 PF13175.6 EMD64210.1 - 3.1e-06 27.2 5.3 3.1e-06 27.2 5.3 3.4 2 1 0 2 2 2 1 AAA ATPase domain AAA_29 PF13555.6 EMD64210.1 - 0.0001 22.0 0.0 0.00022 20.9 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain Atg14 PF10186.9 EMD64210.1 - 0.003 16.7 3.6 0.003 16.7 3.6 5.4 2 2 2 4 4 3 1 Vacuolar sorting 38 and autophagy-related subunit 14 SUB1_ProdP9 PF18213.1 EMD64210.1 - 0.0045 16.8 0.8 0.018 14.9 0.0 2.4 3 0 0 3 3 3 1 SUB1 protease Prodomain ProdP9 AAA_21 PF13304.6 EMD64210.1 - 0.0057 16.5 9.1 0.026 14.3 0.1 3.3 3 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_27 PF13514.6 EMD64210.1 - 0.026 14.1 0.0 0.026 14.1 0.0 4.2 4 1 0 4 4 4 0 AAA domain AAA PF00004.29 EMD64210.1 - 0.026 14.9 0.6 0.15 12.4 0.0 2.7 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 EMD64210.1 - 0.36 10.4 0.0 0.36 10.4 0.0 2.6 3 0 0 3 3 3 0 AAA domain MADF_DNA_bdg PF10545.9 EMD64210.1 - 3.4 8.1 10.0 0.93 9.9 0.4 4.1 3 0 0 3 3 3 0 Alcohol dehydrogenase transcription factor Myb/SANT-like Pkinase PF00069.25 EMD64211.1 - 1e-59 202.1 0.0 6.3e-59 199.5 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD64211.1 - 4.4e-29 101.5 0.2 2.7e-20 72.8 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EMD64211.1 - 0.0017 17.7 0.5 0.0083 15.5 0.0 2.2 3 0 0 3 3 3 1 Kinase-like Pkinase_C PF00433.24 EMD64211.1 - 0.0026 18.4 1.0 0.013 16.2 0.1 2.7 2 0 0 2 2 2 1 Protein kinase C terminal domain APH PF01636.23 EMD64211.1 - 0.0043 17.0 1.9 0.15 12.0 0.1 3.3 3 1 1 4 4 4 1 Phosphotransferase enzyme family Kdo PF06293.14 EMD64211.1 - 0.0091 15.4 0.0 0.025 14.0 0.0 1.7 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EMD64211.1 - 0.018 14.0 0.0 0.042 12.8 0.0 1.7 1 1 0 1 1 1 0 Haspin like kinase domain zf-ANAPC11 PF12861.7 EMD64212.1 - 7.4e-07 29.1 3.0 1.3e-06 28.3 3.0 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 EMD64212.1 - 1.4e-06 28.2 4.4 2.8e-06 27.2 4.4 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 EMD64212.1 - 3.6e-06 27.2 10.2 7.1e-06 26.3 10.2 1.5 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 EMD64212.1 - 7e-06 26.2 9.8 1.2e-05 25.5 9.8 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 EMD64212.1 - 1.1e-05 25.2 7.5 1.9e-05 24.4 7.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EMD64212.1 - 0.00041 20.3 10.1 0.00069 19.5 10.1 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 EMD64212.1 - 0.013 15.6 3.3 0.013 15.6 3.3 1.7 2 0 0 2 2 1 0 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 EMD64212.1 - 0.055 13.3 9.1 0.085 12.7 6.8 2.3 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 EMD64212.1 - 0.079 12.8 8.8 0.25 11.3 8.8 1.8 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EMD64212.1 - 0.14 12.0 8.9 0.86 9.5 8.9 2.2 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Pellino PF04710.14 EMD64212.1 - 0.14 10.8 0.3 0.21 10.2 0.3 1.2 1 0 0 1 1 1 0 Pellino zf-Nse PF11789.8 EMD64212.1 - 0.56 10.1 4.1 1.1 9.1 4.1 1.6 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zinc-ribbons_6 PF07191.12 EMD64212.1 - 0.64 10.0 6.4 0.9 9.6 0.8 2.2 2 0 0 2 2 2 0 zinc-ribbons FANCL_C PF11793.8 EMD64212.1 - 3.1 8.1 7.1 5.7 7.2 7.1 1.4 1 0 0 1 1 1 0 FANCL C-terminal domain Lyase_1 PF00206.20 EMD64214.1 - 1.7e-113 379.2 0.0 2.5e-113 378.6 0.0 1.2 1 0 0 1 1 1 1 Lyase FumaraseC_C PF10415.9 EMD64214.1 - 1.6e-20 73.2 0.1 3.7e-20 72.1 0.1 1.7 1 0 0 1 1 1 1 Fumarase C C-terminus Ank_4 PF13637.6 EMD64216.1 - 3.6e-18 65.7 0.7 1.8e-13 50.7 0.1 2.2 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EMD64216.1 - 1.8e-15 57.2 1.0 2.4e-15 56.9 1.0 1.2 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 EMD64216.1 - 1.6e-12 47.3 5.4 5.5e-05 23.4 0.5 3.1 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.6 EMD64216.1 - 2.1e-11 43.8 4.0 7.1e-07 29.4 0.2 3.0 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMD64216.1 - 8.6e-11 41.1 1.8 5.8e-05 23.2 0.1 3.1 3 0 0 3 3 3 3 Ankyrin repeat DUF1843 PF08898.10 EMD64216.1 - 0.01 16.3 2.6 0.4 11.2 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1843) Pyr_redox_2 PF07992.14 EMD64217.1 - 1.6e-08 34.2 0.0 0.001 18.3 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EMD64217.1 - 7.8e-06 25.2 0.0 1.3e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 EMD64217.1 - 1.3e-05 25.3 0.0 3.3e-05 24.0 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 EMD64217.1 - 4.3e-05 22.9 0.1 0.00018 20.9 0.0 2.0 3 1 0 3 3 3 1 FAD binding domain Pyr_redox PF00070.27 EMD64217.1 - 0.00023 21.7 0.1 0.0065 17.0 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EMD64217.1 - 0.0014 18.0 0.0 0.0025 17.3 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO PF01266.24 EMD64217.1 - 0.0019 17.9 0.0 0.27 10.8 0.0 2.1 2 0 0 2 2 2 2 FAD dependent oxidoreductase HI0933_like PF03486.14 EMD64217.1 - 0.0027 16.5 0.1 0.05 12.3 0.0 2.2 2 0 0 2 2 2 1 HI0933-like protein Lycopene_cycl PF05834.12 EMD64217.1 - 0.0041 16.2 0.0 0.006 15.7 0.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_3 PF13738.6 EMD64217.1 - 0.029 13.6 0.0 0.51 9.5 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EMD64217.1 - 0.046 13.7 1.6 4.6 7.2 0.0 3.1 3 0 0 3 3 3 0 FAD-NAD(P)-binding GIDA PF01134.22 EMD64217.1 - 0.15 11.2 0.1 0.33 10.0 0.0 1.5 2 0 0 2 2 2 0 Glucose inhibited division protein A WD40 PF00400.32 EMD64218.1 - 3.9e-26 90.8 2.2 3.7e-10 40.2 0.1 3.8 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD64218.1 - 5.5e-12 45.8 0.1 4.2e-05 23.8 0.0 3.2 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Helo_like_N PF17111.5 EMD64218.1 - 2.7e-09 36.7 0.8 4.9e-09 35.9 0.8 1.4 1 0 0 1 1 1 1 Fungal N-terminal domain of STAND proteins AAA_16 PF13191.6 EMD64218.1 - 9.4e-08 32.6 0.4 1.6e-06 28.6 0.1 2.6 2 0 0 2 2 2 1 AAA ATPase domain Ge1_WD40 PF16529.5 EMD64218.1 - 7.9e-07 28.3 0.1 0.032 13.2 0.0 2.8 1 1 2 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein NACHT PF05729.12 EMD64218.1 - 2.7e-06 27.4 0.0 5.9e-06 26.3 0.0 1.6 1 0 0 1 1 1 1 NACHT domain Proteasome_A_N PF10584.9 EMD64218.1 - 0.00071 19.2 0.0 13 5.6 0.0 3.8 3 0 0 3 3 3 0 Proteasome subunit A N-terminal signature AAA_22 PF13401.6 EMD64218.1 - 0.0012 19.2 0.0 0.0046 17.2 0.0 2.1 1 0 0 1 1 1 1 AAA domain PD40 PF07676.12 EMD64218.1 - 0.0012 18.7 0.1 23 5.1 0.0 3.5 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Nup160 PF11715.8 EMD64218.1 - 0.0013 17.5 0.0 0.42 9.2 0.0 2.4 1 1 1 2 2 2 2 Nucleoporin Nup120/160 NB-ARC PF00931.22 EMD64218.1 - 0.0043 16.3 0.0 0.0096 15.1 0.0 1.6 1 0 0 1 1 1 1 NB-ARC domain Ret2_MD PF18528.1 EMD64218.1 - 0.0072 16.7 0.0 6.5 7.2 0.0 3.3 1 1 2 3 3 3 1 RNA editing 3' terminal uridylyl transferase 2 middle domain AAA_18 PF13238.6 EMD64218.1 - 0.022 15.3 0.0 0.22 12.1 0.0 2.7 3 0 0 3 3 2 0 AAA domain eIF2A PF08662.11 EMD64218.1 - 0.035 14.0 0.0 0.23 11.3 0.0 2.0 1 1 0 1 1 1 0 Eukaryotic translation initiation factor eIF2A AAA_33 PF13671.6 EMD64218.1 - 0.035 14.3 0.0 0.19 11.9 0.0 2.4 2 0 0 2 2 1 0 AAA domain PLU-1 PF08429.11 EMD64218.1 - 0.035 13.3 1.1 0.065 12.4 1.1 1.3 1 0 0 1 1 1 0 PLU-1-like protein AAA PF00004.29 EMD64218.1 - 0.036 14.5 0.1 0.12 12.8 0.1 1.9 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Snf7 PF03357.21 EMD64218.1 - 0.094 12.3 0.8 0.21 11.2 0.8 1.5 1 0 0 1 1 1 0 Snf7 SesA PF17107.5 EMD64218.1 - 0.1 12.8 1.1 0.22 11.7 1.1 1.6 1 0 0 1 1 1 0 N-terminal domain on NACHT_NTPase and P-loop NTPases RNA_helicase PF00910.22 EMD64218.1 - 0.12 12.8 0.1 0.39 11.1 0.0 1.9 2 0 0 2 2 2 0 RNA helicase APS_kinase PF01583.20 EMD64218.1 - 0.15 11.9 0.1 0.34 10.8 0.1 1.5 1 0 0 1 1 1 0 Adenylylsulphate kinase OmpH PF03938.14 EMD64218.1 - 0.37 11.1 1.7 0.72 10.2 1.7 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Syntaxin_2 PF14523.6 EMD64218.1 - 0.39 11.1 6.4 2.2 8.7 1.9 2.5 2 0 0 2 2 2 0 Syntaxin-like protein AAA_23 PF13476.6 EMD64218.1 - 0.98 9.9 3.5 25 5.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain HTH_Tnp_Tc5 PF03221.16 EMD64219.1 - 1.2e-05 25.3 0.0 2.5e-05 24.2 0.0 1.6 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain DUF5029 PF16432.5 EMD64221.1 - 0.16 11.5 0.0 0.22 11.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5029) Fungal_trans PF04082.18 EMD64222.1 - 1.7e-19 69.9 0.0 3e-19 69.1 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD64222.1 - 0.00077 19.5 8.9 0.0016 18.5 8.9 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain YvfG PF09628.10 EMD64222.1 - 0.2 12.0 0.0 0.48 10.8 0.0 1.5 1 0 0 1 1 1 0 YvfG protein N2227 PF07942.12 EMD64223.1 - 4.3e-57 193.4 0.0 6.7e-57 192.7 0.0 1.3 1 0 0 1 1 1 1 N2227-like protein Methyltransf_11 PF08241.12 EMD64223.1 - 7.1e-07 29.8 0.1 1.2e-05 25.9 0.0 2.8 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMD64223.1 - 0.00025 21.7 0.2 0.0016 19.1 0.0 2.5 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMD64223.1 - 0.00033 21.3 0.0 0.00083 20.1 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EMD64223.1 - 0.00044 20.1 0.0 0.0011 18.9 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMD64223.1 - 0.0055 16.5 0.2 0.041 13.7 0.0 2.4 3 0 0 3 3 3 1 Methyltransferase domain NFRKB_winged PF14465.6 EMD64223.1 - 0.13 12.5 0.0 8.3 6.7 0.0 2.8 2 0 0 2 2 2 0 NFRKB Winged Helix-like Sugar_tr PF00083.24 EMD64224.1 - 1.7e-104 350.3 25.9 1.9e-104 350.1 25.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD64224.1 - 3.8e-27 95.2 33.8 5.7e-24 84.7 17.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 EMD64224.1 - 8.2e-05 21.1 0.7 8.2e-05 21.1 0.7 3.4 1 1 1 3 3 3 1 Organic Anion Transporter Polypeptide (OATP) family YqhR PF11085.8 EMD64224.1 - 0.79 9.6 10.6 2.1 8.3 0.8 2.9 2 1 0 2 2 2 0 Conserved membrane protein YqhR Phage_holin_3_2 PF04550.12 EMD64224.1 - 1.1 9.8 8.2 1.3 9.6 1.7 3.2 3 0 0 3 3 3 0 Phage holin family 2 SGL PF08450.12 EMD64225.1 - 2.5e-31 109.1 0.1 4.3e-31 108.4 0.1 1.4 1 0 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Arylesterase PF01731.20 EMD64225.1 - 1.1e-05 25.5 0.0 3.8e-05 23.8 0.0 2.0 1 1 0 1 1 1 1 Arylesterase NHL PF01436.21 EMD64225.1 - 1.3e-05 24.9 2.0 0.07 13.2 0.0 3.3 4 0 0 4 4 4 2 NHL repeat Str_synth PF03088.16 EMD64225.1 - 0.0063 16.6 0.0 0.03 14.4 0.0 2.2 1 1 0 1 1 1 1 Strictosidine synthase DUF5074 PF16819.5 EMD64225.1 - 0.043 13.8 0.0 1.8 8.6 0.0 3.3 3 1 0 3 3 3 0 Domain of unknown function (DUF5074) Kelch_4 PF13418.6 EMD64225.1 - 0.071 13.1 0.1 0.7 10.0 0.3 2.3 2 0 0 2 2 2 0 Galactose oxidase, central domain DUF4050 PF13259.6 EMD64227.1 - 4.9e-45 154.1 7.7 1.6e-27 97.0 0.4 2.2 1 1 1 2 2 2 2 Protein of unknown function (DUF4050) Peptidase_C2 PF00648.21 EMD64228.1 - 1.8e-65 220.9 0.9 2.6e-42 144.9 0.1 2.3 2 0 0 2 2 2 2 Calpain family cysteine protease EMP24_GP25L PF01105.24 EMD64228.1 - 0.81 9.6 2.7 1.2 9.0 0.9 2.0 2 0 0 2 2 2 0 emp24/gp25L/p24 family/GOLD DUF778 PF05608.12 EMD64230.1 - 7.7 6.8 8.6 10 6.5 7.4 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF778) Sugar_tr PF00083.24 EMD64231.1 - 1.3e-73 248.4 18.8 1.6e-73 248.1 18.8 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD64231.1 - 3.2e-16 59.2 37.7 1.3e-11 44.0 16.1 2.7 1 1 2 3 3 3 2 Major Facilitator Superfamily MFS_1_like PF12832.7 EMD64231.1 - 4.1e-05 22.6 2.2 4.1e-05 22.6 2.2 2.4 2 1 0 2 2 2 1 MFS_1 like family Phage_holin_7_1 PF16081.5 EMD64231.1 - 0.012 15.8 0.4 0.033 14.4 0.4 1.7 1 0 0 1 1 1 0 Mycobacterial 2 TMS Phage Holin (M2 Hol) Family DDE_3 PF13358.6 EMD64232.1 - 7e-06 25.9 1.0 7e-06 25.9 1.0 1.4 2 0 0 2 2 2 1 DDE superfamily endonuclease Glyco_hydro_35 PF01301.19 EMD64233.1 - 1.1e-88 297.9 0.8 2.6e-88 296.7 0.8 1.5 1 1 0 1 1 1 1 Glycosyl hydrolases family 35 BetaGal_dom4_5 PF13364.6 EMD64233.1 - 1.1e-55 187.0 11.9 2.4e-31 108.7 0.0 3.8 5 0 0 5 5 5 2 Beta-galactosidase jelly roll domain BetaGal_dom2 PF10435.9 EMD64233.1 - 8.7e-54 182.1 6.7 1.4e-53 181.4 6.7 1.4 1 0 0 1 1 1 1 Beta-galactosidase, domain 2 BetaGal_dom3 PF13363.6 EMD64233.1 - 2.7e-26 90.9 0.0 6e-26 89.8 0.0 1.6 1 0 0 1 1 1 1 Beta-galactosidase, domain 3 Sel1 PF08238.12 EMD64234.1 - 3.5e-36 122.8 34.7 1.1e-07 32.2 0.3 7.7 8 0 0 8 8 8 7 Sel1 repeat TPR_6 PF13174.6 EMD64234.1 - 0.048 14.3 8.3 7.1 7.5 0.4 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EMD64234.1 - 0.26 11.5 5.4 1.9 8.7 0.2 3.2 3 0 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.6 EMD64234.1 - 6.5 7.9 7.4 2.1 9.4 0.1 3.6 3 1 1 4 4 4 0 Tetratricopeptide repeat CBP4 PF07960.11 EMD64235.1 - 9.4e-29 99.9 1.2 1e-28 99.8 1.2 1.0 1 0 0 1 1 1 1 CBP4 DUF4574 PF15141.6 EMD64235.1 - 7.9e-05 22.5 0.2 0.0002 21.2 0.0 1.7 1 1 1 2 2 2 1 Ubiquinol-cytochrome-c reductase complex assembly factor 3 Tmemb_161AB PF10268.9 EMD64235.1 - 0.21 10.2 0.0 0.29 9.7 0.0 1.2 1 0 0 1 1 1 0 Predicted transmembrane protein 161AB ERCC4 PF02732.15 EMD64236.1 - 5.4e-21 75.4 0.0 1e-20 74.5 0.0 1.5 1 0 0 1 1 1 1 ERCC4 domain DUF4780 PF16012.5 EMD64236.1 - 0.18 11.3 0.0 10 5.5 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4780) eIF-1a PF01176.19 EMD64237.1 - 4.1e-22 77.7 0.1 5.9e-22 77.2 0.1 1.2 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 Sigma70_r2 PF04542.14 EMD64238.1 - 0.037 13.8 0.4 0.084 12.7 0.4 1.6 1 0 0 1 1 1 0 Sigma-70 region 2 Aspzincin_M35 PF14521.6 EMD64239.1 - 9.1e-05 23.0 1.1 0.11 13.1 0.9 2.4 2 0 0 2 2 2 2 Lysine-specific metallo-endopeptidase HRXXH PF13933.6 EMD64239.1 - 0.16 11.6 0.9 0.26 10.8 0.0 1.9 2 0 0 2 2 2 0 Putative peptidase family MFS_1 PF07690.16 EMD64241.1 - 2.9e-41 141.6 25.5 2.9e-41 141.6 25.5 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EMD64241.1 - 1.6e-10 40.5 19.3 5.7e-10 38.6 19.0 1.8 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD64242.1 - 9.5e-40 136.6 41.3 2.3e-39 135.4 39.7 2.4 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EMD64242.1 - 4.5e-13 48.9 8.3 4.5e-13 48.9 8.3 2.8 2 1 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 EMD64242.1 - 2.8e-12 45.9 12.8 4.2e-12 45.3 12.8 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) F-box-like PF12937.7 EMD64243.1 - 6.3e-05 22.8 0.1 9.3e-05 22.2 0.1 1.3 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EMD64243.1 - 0.014 15.3 0.2 0.025 14.4 0.2 1.4 1 0 0 1 1 1 0 F-box domain Aminotran_1_2 PF00155.21 EMD64244.1 - 3.3e-37 128.5 0.0 4.8e-37 128.0 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EMD64244.1 - 0.032 12.8 0.0 0.045 12.3 0.0 1.1 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme DUF4350 PF14258.6 EMD64244.1 - 0.089 13.2 0.0 0.24 11.9 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4350) RPN7 PF10602.9 EMD64245.1 - 6e-55 185.6 1.0 9.3e-55 185.0 1.0 1.3 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.27 EMD64245.1 - 9.5e-15 55.0 0.0 1.9e-14 54.0 0.0 1.5 1 0 0 1 1 1 1 PCI domain TPR_8 PF13181.6 EMD64245.1 - 0.14 12.4 2.1 0.23 11.8 0.2 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat Pox_MCEL PF03291.16 EMD64246.1 - 2.4e-69 234.0 0.0 8.7e-48 163.1 0.0 2.4 2 1 0 2 2 2 2 mRNA capping enzyme Methyltransf_12 PF08242.12 EMD64246.1 - 5e-11 43.2 0.0 2.3e-10 41.1 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMD64246.1 - 2.2e-09 37.9 0.0 3.1e-05 24.6 0.0 2.6 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_31 PF13847.6 EMD64246.1 - 3.2e-06 27.0 0.0 3.4e-05 23.7 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMD64246.1 - 1.8e-05 25.3 0.0 0.0002 21.9 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EMD64246.1 - 0.00045 20.1 0.0 0.00077 19.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Raftlin PF15250.6 EMD64246.1 - 0.0075 15.1 0.3 0.0075 15.1 0.3 1.8 2 0 0 2 2 2 1 Raftlin DDRGK PF09756.9 EMD64246.1 - 0.0089 15.6 1.3 0.0089 15.6 1.3 2.3 2 0 0 2 2 2 1 DDRGK domain NNMT_PNMT_TEMT PF01234.17 EMD64246.1 - 0.026 13.7 0.0 0.1 11.8 0.0 1.8 2 0 0 2 2 2 0 NNMT/PNMT/TEMT family PEX11 PF05648.14 EMD64247.1 - 3.6e-70 235.9 0.3 4.1e-70 235.7 0.3 1.0 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) DUF5527 PF17665.1 EMD64248.1 - 0.036 13.6 0.0 0.1 12.1 0.0 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5527) Sugar_tr PF00083.24 EMD64249.1 - 4.2e-27 95.1 24.3 1.9e-17 63.3 9.4 2.0 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 EMD64249.1 - 4.8e-15 55.3 42.4 1.7e-13 50.2 40.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF5305 PF17231.2 EMD64251.1 - 0.0031 17.0 0.0 0.0041 16.6 0.0 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5305) DUF3377 PF11857.8 EMD64251.1 - 0.0046 16.8 0.0 0.0077 16.1 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3377) TMEM154 PF15102.6 EMD64251.1 - 0.0054 16.6 0.0 0.0059 16.5 0.0 1.2 1 0 0 1 1 1 1 TMEM154 protein family MFS_2 PF13347.6 EMD64251.1 - 0.064 11.8 0.0 0.079 11.5 0.0 1.0 1 0 0 1 1 1 0 MFS/sugar transport protein Orf78 PF06024.12 EMD64251.1 - 0.073 13.4 0.0 0.11 12.8 0.0 1.3 1 0 0 1 1 1 0 Orf78 (ac78) DUF2207 PF09972.9 EMD64251.1 - 0.1 11.3 0.0 0.12 11.1 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) EphA2_TM PF14575.6 EMD64251.1 - 0.11 13.4 0.0 0.15 13.0 0.0 1.3 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain PAG PF15347.6 EMD64251.1 - 0.15 11.1 0.0 0.18 10.8 0.0 1.1 1 0 0 1 1 1 0 Phosphoprotein associated with glycosphingolipid-enriched AMA-1 PF02430.15 EMD64251.1 - 0.17 10.8 0.0 0.19 10.6 0.0 1.1 1 0 0 1 1 1 0 Apical membrane antigen 1 TMEMspv1-c74-12 PF11044.8 EMD64251.1 - 3.5 7.7 9.7 0.14 12.2 3.0 2.2 2 1 0 2 2 2 0 Plectrovirus spv1-c74 ORF 12 transmembrane protein HECT PF00632.25 EMD64252.1 - 5.7e-81 272.3 0.0 2.5e-80 270.2 0.0 1.9 2 0 0 2 2 2 1 HECT-domain (ubiquitin-transferase) HEAT_EZ PF13513.6 EMD64252.1 - 0.0033 17.9 0.0 0.32 11.5 0.0 3.7 3 0 0 3 3 3 1 HEAT-like repeat HEAT PF02985.22 EMD64252.1 - 0.048 13.9 0.2 28 5.3 0.0 4.1 3 0 0 3 3 3 0 HEAT repeat Adaptin_N PF01602.20 EMD64252.1 - 0.051 12.1 4.1 1.8 7.0 0.0 3.0 3 0 0 3 3 3 0 Adaptin N terminal region Wap1 PF16997.5 EMD64252.1 - 0.064 12.4 0.3 0.13 11.4 0.0 1.7 2 0 0 2 2 2 0 Wap1 domain Cwf_Cwc_15 PF04889.12 EMD64252.1 - 0.94 9.2 38.8 0.51 10.0 19.5 2.7 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein GCIP PF13324.6 EMD64252.1 - 1.2 8.6 14.2 2 8.0 3.0 3.0 2 0 0 2 2 2 0 Grap2 and cyclin-D-interacting CTP_transf_like PF01467.26 EMD64254.1 - 7.8e-24 84.5 0.0 1e-23 84.1 0.0 1.1 1 0 0 1 1 1 1 Cytidylyltransferase-like Cellulase PF00150.18 EMD64255.1 - 1.7e-15 57.2 6.5 1e-14 54.6 6.5 1.9 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) ETRAMP PF09716.10 EMD64255.1 - 0.0098 15.9 0.1 0.033 14.2 0.1 1.9 1 0 0 1 1 1 1 Malarial early transcribed membrane protein (ETRAMP) ABC_export PF16962.5 EMD64255.1 - 0.75 8.2 0.0 0.75 8.2 0.0 1.9 2 0 0 2 2 2 0 Putative ABC exporter OapA_N PF08525.11 EMD64255.1 - 2.9 7.9 7.5 4.9 7.2 7.5 1.4 1 0 0 1 1 1 0 Opacity-associated protein A N-terminal motif DUF1771 PF08590.10 EMD64257.1 - 6.9e-07 29.6 2.9 1.5e-06 28.4 2.9 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1771) Smr PF01713.21 EMD64257.1 - 5.9e-05 23.4 0.1 0.0015 18.9 0.0 2.5 2 0 0 2 2 2 1 Smr domain Shisa PF13908.6 EMD64258.1 - 0.028 14.7 0.0 0.032 14.5 0.0 1.1 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator YajC PF02699.15 EMD64258.1 - 0.044 13.7 0.2 0.044 13.7 0.2 1.5 2 0 0 2 2 2 0 Preprotein translocase subunit EphA2_TM PF14575.6 EMD64258.1 - 0.12 13.3 0.5 0.15 13.0 0.3 1.5 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain MLANA PF14991.6 EMD64258.1 - 0.12 12.6 0.0 0.15 12.4 0.0 1.2 1 0 0 1 1 1 0 Protein melan-A LapA_dom PF06305.11 EMD64258.1 - 0.23 11.3 0.2 0.37 10.6 0.2 1.3 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain F-box-like PF12937.7 EMD64259.1 - 3.9e-09 36.2 0.4 1e-07 31.7 0.0 2.8 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EMD64259.1 - 0.0055 16.5 0.5 0.0055 16.5 0.5 2.5 2 1 0 2 2 2 1 F-box domain zf-CCHC PF00098.23 EMD64260.1 - 0.0025 17.8 2.5 0.0025 17.8 2.5 3.2 4 0 0 4 4 4 1 Zinc knuckle Anti-TRAP PF15777.5 EMD64260.1 - 0.025 14.6 6.8 0.066 13.2 6.8 1.7 1 0 0 1 1 1 0 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.19 EMD64260.1 - 0.34 10.9 5.3 0.32 11.0 2.8 2.1 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Abhydrolase_1 PF00561.20 EMD64261.1 - 8.8e-05 22.3 0.0 0.00019 21.2 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EMD64261.1 - 0.003 18.2 2.4 0.0087 16.7 0.1 2.3 2 1 0 2 2 2 1 Alpha/beta hydrolase family Chlorophyllase2 PF12740.7 EMD64261.1 - 0.02 13.8 0.2 0.088 11.7 0.2 1.8 1 1 0 1 1 1 0 Chlorophyllase enzyme Hydrolase_4 PF12146.8 EMD64261.1 - 0.1 11.9 0.0 0.38 10.0 0.0 1.9 2 0 0 2 2 2 0 Serine aminopeptidase, S33 DUF1100 PF06500.11 EMD64262.1 - 1.3e-13 50.6 0.0 2e-13 50.0 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1100) Peptidase_S15 PF02129.18 EMD64262.1 - 7.8e-05 22.4 0.3 0.00022 20.9 0.0 1.9 2 1 0 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) Peptidase_S9 PF00326.21 EMD64262.1 - 0.00066 19.2 0.0 0.0017 17.9 0.0 1.8 1 1 0 1 1 1 1 Prolyl oligopeptidase family BAAT_C PF08840.11 EMD64262.1 - 0.03 14.2 0.0 0.054 13.4 0.0 1.3 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_6 PF12697.7 EMD64262.1 - 0.035 14.7 0.1 0.052 14.1 0.1 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family Esterase PF00756.20 EMD64262.1 - 0.039 13.6 0.2 0.15 11.6 0.2 1.9 1 1 0 1 1 1 0 Putative esterase D5_N PF08706.11 EMD64262.1 - 0.066 13.5 0.2 0.15 12.3 0.2 1.6 1 1 0 1 1 1 0 D5 N terminal like DNA_pol_A_exo1 PF01612.20 EMD64264.1 - 6.7e-05 22.7 0.1 0.00026 20.8 0.0 1.8 2 0 0 2 2 2 1 3'-5' exonuclease PTR2 PF00854.21 EMD64265.1 - 5.3e-85 285.6 10.6 7.6e-85 285.1 10.6 1.2 1 0 0 1 1 1 1 POT family Putative_PNPOx PF01243.20 EMD64266.1 - 1.9e-05 24.8 0.0 3.3e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Peptidase_M20 PF01546.28 EMD64267.1 - 5.6e-24 85.0 0.0 2.4e-23 82.9 0.0 1.9 2 0 0 2 2 2 1 Peptidase family M20/M25/M40 WD40 PF00400.32 EMD64267.1 - 1.8e-11 44.4 3.9 0.0042 17.9 0.1 5.7 7 0 0 7 7 7 4 WD domain, G-beta repeat M20_dimer PF07687.14 EMD64267.1 - 1.7e-07 31.1 0.0 3.4e-07 30.2 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain ANAPC4_WD40 PF12894.7 EMD64267.1 - 0.0049 17.1 0.0 0.36 11.2 0.0 3.2 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EMD64267.1 - 0.055 12.8 0.0 4.3 6.6 0.0 2.3 2 0 0 2 2 2 0 WD40-like domain Cornifin PF02389.15 EMD64268.1 - 0.061 13.5 0.0 0.13 12.4 0.0 1.5 1 0 0 1 1 1 0 Cornifin (SPRR) family RAP1 PF07218.11 EMD64268.1 - 6 5.0 19.9 13 3.9 19.9 1.5 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) FAD_binding_3 PF01494.19 EMD64269.1 - 5.4e-19 68.6 0.0 1.4e-18 67.3 0.0 1.6 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.24 EMD64269.1 - 4.1e-09 36.5 0.1 3e-05 23.8 0.0 2.2 1 1 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EMD64269.1 - 4.8e-05 23.5 0.0 0.00031 20.9 0.0 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Trp_halogenase PF04820.14 EMD64269.1 - 0.018 13.9 0.3 1.7 7.4 0.0 2.1 1 1 0 2 2 2 0 Tryptophan halogenase Lycopene_cycl PF05834.12 EMD64269.1 - 0.067 12.2 0.0 0.12 11.4 0.0 1.4 1 0 0 1 1 1 0 Lycopene cyclase protein Amidase_6 PF12671.7 EMD64269.1 - 0.11 12.7 0.4 0.27 11.3 0.1 1.7 1 1 1 2 2 2 0 Putative amidase domain Pyr_redox PF00070.27 EMD64269.1 - 0.12 13.0 0.0 1.2 9.7 0.0 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EMD64269.1 - 0.12 11.6 0.1 3.3 6.9 0.1 2.1 1 1 1 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase adh_short PF00106.25 EMD64270.1 - 1e-21 77.3 0.1 4.2e-15 55.7 0.0 2.2 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EMD64270.1 - 1.3e-15 57.6 0.3 2.5e-08 33.8 0.0 2.2 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 EMD64270.1 - 1.6e-08 34.3 0.0 2.1e-08 33.9 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EMD64270.1 - 4.9e-06 26.6 0.2 8.6e-06 25.8 0.2 1.4 1 1 0 1 1 1 1 NAD(P)H-binding KR PF08659.10 EMD64270.1 - 1.5e-05 25.0 0.3 3.3e-05 23.9 0.1 1.6 2 0 0 2 2 2 1 KR domain ADH_zinc_N PF00107.26 EMD64270.1 - 0.009 16.0 0.1 0.021 14.8 0.1 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase NmrA PF05368.13 EMD64270.1 - 0.16 11.5 0.1 0.22 11.0 0.1 1.3 1 0 0 1 1 1 0 NmrA-like family Ank_2 PF12796.7 EMD64271.1 - 6.1e-40 135.7 2.1 1e-10 42.1 0.0 9.0 8 2 1 9 9 9 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMD64271.1 - 2.6e-31 107.6 4.1 2.4e-06 27.9 0.0 10.9 10 1 1 11 11 11 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMD64271.1 - 4.9e-25 84.8 4.4 0.039 14.5 0.1 12.4 14 0 0 14 14 14 5 Ankyrin repeat Ank_5 PF13857.6 EMD64271.1 - 1.1e-24 86.2 3.7 0.00013 22.2 0.0 9.4 8 1 1 9 9 9 5 Ankyrin repeats (many copies) Ank PF00023.30 EMD64271.1 - 3e-22 78.0 19.3 0.0038 17.6 0.0 11.4 13 1 0 13 13 13 5 Ankyrin repeat RVP PF00077.20 EMD64271.1 - 0.052 13.9 0.0 0.39 11.0 0.0 2.5 2 0 0 2 2 2 0 Retroviral aspartyl protease RCC1_2 PF13540.6 EMD64272.1 - 1.1e-07 31.5 3.4 0.0027 17.4 0.0 3.1 3 0 0 3 3 3 2 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EMD64272.1 - 0.00049 20.7 5.6 0.26 12.0 0.1 4.3 3 1 0 3 3 3 1 Regulator of chromosome condensation (RCC1) repeat Peptidase_A22B PF04258.13 EMD64274.1 - 1.9e-61 208.1 2.0 6.4e-60 203.1 2.0 2.5 1 1 0 1 1 1 1 Signal peptide peptidase SPP PF06550.11 EMD64274.1 - 4.5e-05 23.1 2.1 4.5e-05 23.1 2.1 2.0 2 0 0 2 2 2 1 Signal-peptide peptidase, presenilin aspartyl protease FAM176 PF14851.6 EMD64274.1 - 0.09 12.4 0.1 0.09 12.4 0.1 3.3 2 1 1 3 3 3 0 FAM176 family RXT2_N PF08595.11 EMD64274.1 - 0.25 11.4 0.1 0.25 11.4 0.1 2.5 2 1 0 2 2 2 0 RXT2-like, N-terminal DUF4834 PF16118.5 EMD64274.1 - 0.88 10.6 2.4 14 6.7 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) MscS_TM PF12794.7 EMD64274.1 - 2.2 7.1 9.2 5.8 5.7 0.2 2.9 3 0 0 3 3 3 0 Mechanosensitive ion channel inner membrane domain 1 Helo_like_N PF17111.5 EMD64275.1 - 1.3e-19 70.4 2.7 2.1e-19 69.7 2.7 1.3 1 0 0 1 1 1 1 Fungal N-terminal domain of STAND proteins Baculo_PEP_C PF04513.12 EMD64275.1 - 0.47 10.5 3.6 2.6 8.1 0.2 2.7 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF3037 PF11236.8 EMD64275.1 - 1.2 9.6 3.8 2.4 8.6 1.9 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3037) PRKCSH-like PF12999.7 EMD64275.1 - 5.9 6.7 6.7 1.3 8.8 0.2 2.2 1 1 1 2 2 2 0 Glucosidase II beta subunit-like NACHT PF05729.12 EMD64276.1 - 3.1e-12 46.7 0.1 4.9e-12 46.1 0.1 1.3 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 EMD64276.1 - 0.00023 21.4 0.0 0.00045 20.5 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EMD64276.1 - 0.024 15.0 0.0 0.042 14.2 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain KAP_NTPase PF07693.14 EMD64276.1 - 0.027 13.7 0.5 0.25 10.5 0.1 1.8 1 1 1 2 2 2 0 KAP family P-loop domain RNA_helicase PF00910.22 EMD64276.1 - 0.039 14.4 0.0 0.072 13.5 0.0 1.4 1 0 0 1 1 1 0 RNA helicase AAA_28 PF13521.6 EMD64276.1 - 0.077 13.2 0.0 0.44 10.8 0.0 2.0 2 0 0 2 2 2 0 AAA domain Ploopntkinase3 PF18751.1 EMD64276.1 - 0.11 12.4 0.0 0.18 11.7 0.0 1.3 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 PH_TFIIH PF08567.11 EMD64276.1 - 0.16 12.4 0.0 0.32 11.4 0.0 1.5 1 0 0 1 1 1 0 TFIIH p62 subunit, N-terminal domain Ank_5 PF13857.6 EMD64277.1 - 0.026 14.9 0.0 0.038 14.3 0.0 1.3 1 0 0 1 1 1 0 Ankyrin repeats (many copies) ADH_N PF08240.12 EMD64278.1 - 1.2e-18 66.9 0.2 1.5e-18 66.7 0.2 1.1 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_N_assoc PF13823.6 EMD64278.1 - 1.7e-06 27.8 1.2 1.8e-06 27.7 0.1 1.7 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-associated ADH_zinc_N PF00107.26 EMD64279.1 - 1.3e-07 31.6 0.1 2.4e-07 30.8 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EMD64279.1 - 0.00043 19.8 0.0 0.0043 16.6 0.0 1.9 2 0 0 2 2 2 1 Glucose dehydrogenase C-terminus AlaDh_PNT_C PF01262.21 EMD64279.1 - 0.0059 15.9 0.2 0.0085 15.4 0.2 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain HI0933_like PF03486.14 EMD64279.1 - 0.0096 14.7 0.5 0.053 12.2 0.2 1.9 2 0 0 2 2 2 1 HI0933-like protein Pro_isomerase PF00160.21 EMD64280.1 - 1e-54 185.1 0.0 1.2e-54 184.9 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD zf-C2HC5 PF06221.13 EMD64281.1 - 7e-23 80.4 7.4 1.4e-22 79.4 7.4 1.5 1 0 0 1 1 1 1 Putative zinc finger motif, C2HC5-type FYVE PF01363.21 EMD64281.1 - 0.057 13.6 0.5 0.11 12.7 0.5 1.4 1 0 0 1 1 1 0 FYVE zinc finger Tropomodulin PF03250.14 EMD64281.1 - 0.07 13.2 1.3 0.21 11.7 1.3 1.7 1 0 0 1 1 1 0 Tropomodulin MBOAT_2 PF13813.6 EMD64284.1 - 4e-16 59.0 4.9 4e-16 59.0 4.9 2.8 3 0 0 3 3 3 1 Membrane bound O-acyl transferase family fn3_2 PF16893.5 EMD64285.1 - 3.1e-40 136.2 0.1 5.5e-40 135.4 0.1 1.4 1 0 0 1 1 1 1 Fibronectin type III domain CHS5_N PF16892.5 EMD64285.1 - 2e-22 78.8 0.4 3.4e-22 78.1 0.4 1.4 1 0 0 1 1 1 1 Chitin biosynthesis protein CHS5 N-terminus PTCB-BRCT PF12738.7 EMD64285.1 - 1.1e-15 57.3 0.0 2e-15 56.5 0.0 1.4 1 0 0 1 1 1 1 twin BRCT domain BRCT PF00533.26 EMD64285.1 - 5.8e-10 39.4 0.0 1.2e-09 38.4 0.0 1.6 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain DUF3006 PF11213.8 EMD64285.1 - 0.00019 21.6 0.0 0.00059 20.0 0.0 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF3006) BRCT_2 PF16589.5 EMD64285.1 - 0.0005 20.4 0.1 0.0013 19.1 0.0 1.7 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain fn3 PF00041.21 EMD64285.1 - 0.0015 18.9 0.0 0.0015 18.9 0.0 2.0 2 0 0 2 2 1 1 Fibronectin type III domain PPL4 PF18188.1 EMD64285.1 - 0.022 14.7 0.0 0.039 13.9 0.0 1.3 1 0 0 1 1 1 0 Prim-pol 4 BRCT_3 PF18428.1 EMD64285.1 - 0.058 13.5 0.0 0.15 12.2 0.0 1.8 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain TFIIA PF03153.13 EMD64285.1 - 0.086 12.8 30.5 0.16 11.9 30.5 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF1297 PF06973.12 EMD64285.1 - 0.092 12.3 0.0 0.15 11.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1297) LIM_bind PF01803.16 EMD64285.1 - 4.9 6.6 8.8 0.52 9.8 0.5 2.3 2 0 0 2 2 2 0 LIM-domain binding protein DUF4834 PF16118.5 EMD64285.1 - 9.3 7.3 14.4 0.063 14.2 2.6 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Glyco_hydro_63 PF03200.16 EMD64287.1 - 1e-05 24.5 9.2 2.5e-05 23.2 4.9 3.1 2 1 0 2 2 2 1 Glycosyl hydrolase family 63 C-terminal domain Mob1_phocein PF03637.17 EMD64288.1 - 1.4e-71 240.0 0.0 1.7e-71 239.7 0.0 1.0 1 0 0 1 1 1 1 Mob1/phocein family Glyco_hydro_45 PF02015.16 EMD64290.1 - 4.1e-55 186.9 13.4 5.4e-55 186.6 13.4 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 45 DUF1757 PF08560.10 EMD64291.1 - 2.6e-05 24.3 0.0 3e-05 24.1 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1757) TetR_C_14 PF17754.1 EMD64291.1 - 0.039 13.9 0.4 0.09 12.7 0.2 1.7 1 1 0 1 1 1 0 MftR C-terminal domain Coiled PF05710.12 EMD64292.1 - 0.25 12.2 8.2 0.15 12.9 6.2 1.6 2 0 0 2 2 2 0 Coiled coil PIR PF00399.19 EMD64293.1 - 7.2e-21 73.2 52.5 0.00012 21.6 3.5 5.7 5 0 0 5 5 5 5 Yeast PIR protein repeat Mt_ATP-synt_D PF05873.12 EMD64294.1 - 1.8e-23 83.1 2.4 2.4e-23 82.7 2.4 1.1 1 0 0 1 1 1 1 ATP synthase D chain, mitochondrial (ATP5H) KASH_CCD PF14662.6 EMD64294.1 - 0.00011 22.1 3.5 0.14 12.0 0.9 2.2 2 0 0 2 2 2 2 Coiled-coil region of CCDC155 or KASH TPR_MLP1_2 PF07926.12 EMD64294.1 - 0.013 15.6 6.0 0.62 10.1 0.1 2.2 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Dor1 PF04124.12 EMD64294.1 - 0.045 12.4 2.0 0.057 12.1 2.0 1.2 1 0 0 1 1 1 0 Dor1-like family DUF148 PF02520.17 EMD64294.1 - 0.11 12.6 7.0 0.062 13.4 4.0 2.1 2 1 0 2 2 2 0 Domain of unknown function DUF148 DUF2408 PF10303.9 EMD64294.1 - 0.19 12.3 2.4 0.31 11.6 2.4 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2408) Spectrin PF00435.21 EMD64294.1 - 0.54 10.8 5.8 2.4 8.7 1.1 2.5 1 1 2 3 3 3 0 Spectrin repeat APG6_N PF17675.1 EMD64294.1 - 3 8.4 7.2 2.8 8.5 3.4 2.1 1 1 1 2 2 2 0 Apg6 coiled-coil region Arf PF00025.21 EMD64295.1 - 1.5e-63 213.4 0.0 1.6e-63 213.3 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 EMD64295.1 - 2.4e-12 46.7 0.0 6.2e-09 35.5 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 EMD64295.1 - 2.7e-08 33.4 0.0 3.4e-08 33.1 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 EMD64295.1 - 4.9e-08 33.2 0.0 1.5e-07 31.6 0.0 1.7 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 EMD64295.1 - 1e-07 32.0 0.0 1.3e-07 31.7 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Ras PF00071.22 EMD64295.1 - 5.7e-07 29.3 0.0 7e-07 29.0 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 EMD64295.1 - 9.8e-06 25.1 0.0 1.1e-05 24.9 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EMD64295.1 - 0.01 15.4 0.1 0.31 10.5 0.0 2.0 1 1 0 2 2 2 0 Elongation factor Tu GTP binding domain cobW PF02492.19 EMD64295.1 - 0.044 13.4 0.0 3.3 7.3 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain PduV-EutP PF10662.9 EMD64295.1 - 0.19 11.5 0.0 0.71 9.6 0.0 1.8 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Nup35_RRM PF05172.13 EMD64296.1 - 0.045 13.7 0.1 0.086 12.8 0.1 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Ribosomal_L14e PF01929.17 EMD64297.1 - 1.2e-28 99.4 1.9 2.9e-28 98.2 1.9 1.7 1 0 0 1 1 1 1 Ribosomal protein L14 KOW PF00467.29 EMD64297.1 - 0.0009 19.1 0.4 0.0024 17.7 0.4 1.8 1 0 0 1 1 1 1 KOW motif Med3 PF11593.8 EMD64297.1 - 3.1 6.9 7.6 5.4 6.1 7.6 1.3 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal NAC PF01849.18 EMD64298.1 - 3e-23 81.6 0.0 1.1e-22 79.8 0.0 1.9 2 0 0 2 2 2 1 NAC domain UreE_C PF05194.12 EMD64298.1 - 0.42 11.1 9.8 1.2 9.7 9.8 1.7 1 0 0 1 1 1 0 UreE urease accessory protein, C-terminal domain SelP_N PF04592.14 EMD64298.1 - 0.44 9.9 14.9 0.021 14.2 9.2 1.6 2 0 0 2 2 2 0 Selenoprotein P, N terminal region DUF5308 PF17233.2 EMD64298.1 - 0.88 9.8 8.2 6.2 7.0 0.3 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5308) Myc_N PF01056.18 EMD64298.1 - 1.7 8.4 19.6 0.12 12.2 9.0 2.0 1 1 1 2 2 2 0 Myc amino-terminal region PGA2 PF07543.12 EMD64298.1 - 2.4 8.2 15.7 4 7.4 0.6 2.3 2 0 0 2 2 2 0 Protein trafficking PGA2 RNA_pol_3_Rpc31 PF11705.8 EMD64298.1 - 5.1 7.3 19.1 0.032 14.5 6.0 2.2 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 Cytomega_UL84 PF06284.11 EMD64298.1 - 8.6 4.7 10.3 0.27 9.6 3.2 1.9 2 0 0 2 2 2 0 Cytomegalovirus UL84 protein DTHCT PF08070.11 EMD64298.1 - 9.6 7.0 15.9 1.6 9.5 8.0 2.5 2 1 0 2 2 2 0 DTHCT (NUC029) region Imm27 PF15590.6 EMD64299.1 - 0.14 11.9 0.3 0.43 10.4 0.1 1.8 2 0 0 2 2 2 0 Immunity protein 27 TauD PF02668.16 EMD64300.1 - 4.4e-25 89.0 0.0 7.1e-25 88.3 0.0 1.3 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Zn_clus PF00172.18 EMD64301.1 - 0.0049 17.0 5.1 0.01 16.0 5.1 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF2183 PF09949.9 EMD64302.1 - 1.7e-31 108.5 0.0 4.1e-31 107.2 0.0 1.7 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2183) adh_short PF00106.25 EMD64302.1 - 1.4e-24 86.7 0.1 6.1e-18 65.0 0.1 2.3 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EMD64302.1 - 4.6e-13 49.3 0.0 4e-09 36.4 0.1 2.4 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD64302.1 - 0.0002 21.3 0.1 0.00046 20.1 0.1 1.5 1 0 0 1 1 1 1 KR domain LNS2 PF08235.13 EMD64302.1 - 0.01 15.3 0.1 0.019 14.5 0.1 1.3 1 0 0 1 1 1 0 LNS2 (Lipin/Ned1/Smp2) Polysacc_synt_2 PF02719.15 EMD64302.1 - 0.13 11.3 0.0 0.22 10.6 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein LSM PF01423.22 EMD64303.1 - 6.3e-14 51.4 0.0 9.3e-14 50.9 0.0 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EMD64303.1 - 0.2 11.8 0.0 0.94 9.7 0.0 2.0 2 0 0 2 2 2 0 Ataxin 2 SM domain Cellulase PF00150.18 EMD64306.1 - 1.3e-15 57.6 0.0 1.7e-15 57.3 0.0 1.1 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_2_C PF02836.17 EMD64306.1 - 0.0016 17.6 0.0 0.0022 17.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain DUF2637 PF10935.8 EMD64307.1 - 0.0037 17.2 0.2 2 8.3 0.1 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF2637) HLH PF00010.26 EMD64308.1 - 9.8e-08 31.8 0.0 2.1e-07 30.8 0.0 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DUF5094 PF17015.5 EMD64308.1 - 1.2 9.2 6.2 2.2 8.4 6.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5094) CDC45 PF02724.14 EMD64308.1 - 2.1 6.6 16.7 2.8 6.1 16.7 1.1 1 0 0 1 1 1 0 CDC45-like protein Macoilin PF09726.9 EMD64308.1 - 2.5 6.5 10.7 4 5.9 10.7 1.3 1 0 0 1 1 1 0 Macoilin family SLC12 PF03522.15 EMD64308.1 - 5.2 6.0 8.0 8 5.4 8.0 1.2 1 0 0 1 1 1 0 Solute carrier family 12 Dickkopf_N PF04706.12 EMD64309.1 - 0.0018 18.7 0.3 0.0018 18.7 0.3 4.4 4 0 0 4 4 4 2 Dickkopf N-terminal cysteine-rich region Cnl2_NKP2 PF09447.10 EMD64310.1 - 1.1e-23 83.1 0.8 2.9e-23 81.8 0.2 2.0 2 1 0 2 2 2 1 Cnl2/NKP2 family protein Exonuc_VII_L PF02601.15 EMD64310.1 - 0.036 13.6 0.3 0.043 13.4 0.3 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Mod_r PF07200.13 EMD64310.1 - 0.056 13.5 0.2 0.6 10.2 0.3 2.0 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein DMPK_coil PF08826.10 EMD64310.1 - 0.061 13.4 3.7 0.29 11.3 0.2 2.3 2 0 0 2 2 2 0 DMPK coiled coil domain like SKA2 PF16740.5 EMD64310.1 - 0.066 13.0 0.9 0.18 11.6 0.1 1.9 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 2 TMCO5 PF14992.6 EMD64310.1 - 0.081 12.5 0.8 0.33 10.5 0.8 1.8 1 1 0 1 1 1 0 TMCO5 family Adenylsucc_synt PF00709.21 EMD64310.1 - 0.084 11.8 0.0 0.097 11.6 0.0 1.1 1 0 0 1 1 1 0 Adenylosuccinate synthetase DivIC PF04977.15 EMD64310.1 - 1.2 8.9 5.0 0.95 9.3 0.1 2.4 2 1 0 2 2 2 0 Septum formation initiator MRG PF05712.13 EMD64311.1 - 5.7e-50 169.4 0.6 8.3e-50 168.8 0.6 1.2 1 0 0 1 1 1 1 MRG Tudor-knot PF11717.8 EMD64311.1 - 2.7e-10 40.0 2.2 4.9e-10 39.1 2.2 1.4 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Chromo PF00385.24 EMD64311.1 - 0.02 14.8 0.8 0.053 13.5 0.8 1.7 1 0 0 1 1 1 0 Chromo (CHRromatin Organisation MOdifier) domain DivIVA PF05103.13 EMD64311.1 - 0.15 12.2 3.6 0.12 12.5 1.6 1.8 2 0 0 2 2 2 0 DivIVA protein AAA_18 PF13238.6 EMD64312.1 - 1.4e-06 28.9 0.1 9.7e-06 26.2 0.1 2.1 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EMD64312.1 - 0.0036 17.7 0.0 0.0052 17.2 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.6 EMD64312.1 - 0.022 14.9 0.0 0.097 12.8 0.0 1.9 1 1 0 1 1 1 0 AAA domain Cytidylate_kin PF02224.18 EMD64312.1 - 0.025 14.3 0.0 0.051 13.3 0.0 1.5 1 1 0 1 1 1 0 Cytidylate kinase PRK PF00485.18 EMD64312.1 - 0.025 14.3 0.0 0.046 13.5 0.0 1.7 1 1 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family Spb1_C PF07780.12 EMD64312.1 - 0.092 12.4 0.0 0.14 11.8 0.0 1.2 1 0 0 1 1 1 0 Spb1 C-terminal domain CPT PF07931.12 EMD64312.1 - 0.1 12.4 0.0 0.17 11.7 0.0 1.5 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein AAA_28 PF13521.6 EMD64312.1 - 0.11 12.7 0.0 0.19 12.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EMD64312.1 - 0.14 11.9 0.0 0.24 11.1 0.0 1.5 2 0 0 2 2 2 0 AAA domain RbsD_FucU PF05025.13 EMD64312.1 - 0.16 12.4 0.0 0.29 11.6 0.0 1.5 1 1 0 1 1 1 0 RbsD / FucU transport protein family DUF1741 PF08427.10 EMD64313.1 - 3.6e-83 278.8 0.2 7.5e-83 277.8 0.2 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1741) CwsA PF10814.8 EMD64314.1 - 0.23 11.6 2.3 0.3 11.2 0.5 2.0 1 1 1 2 2 2 0 Cell wall synthesis protein CwsA DTHCT PF08070.11 EMD64315.1 - 4.6 8.0 11.0 0.082 13.7 2.0 2.7 3 0 0 3 3 3 0 DTHCT (NUC029) region IMS PF00817.20 EMD64316.1 - 7.8e-39 133.1 0.0 1.8e-38 131.9 0.0 1.6 2 0 0 2 2 2 1 impB/mucB/samB family IMS_C PF11799.8 EMD64316.1 - 1.6e-19 70.8 0.1 2.5e-18 66.9 0.1 2.2 2 0 0 2 2 2 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.8 EMD64316.1 - 0.003 17.8 0.0 0.008 16.4 0.0 1.8 1 0 0 1 1 1 1 IMS family HHH motif zf_UBZ PF18439.1 EMD64316.1 - 0.033 13.8 0.0 0.068 12.8 0.0 1.6 1 0 0 1 1 1 0 Ubiquitin-Binding Zinc Finger HHH_5 PF14520.6 EMD64316.1 - 0.072 13.7 0.0 0.48 11.1 0.0 2.3 2 0 0 2 2 2 0 Helix-hairpin-helix domain Pyridoxal_deC PF00282.19 EMD64317.1 - 7.2e-17 61.2 0.0 1.1e-16 60.6 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.19 EMD64317.1 - 6.5e-07 28.6 0.0 1.1e-06 27.8 0.0 1.3 1 1 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 EMD64317.1 - 0.00041 19.8 0.0 0.00064 19.1 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.20 EMD64317.1 - 0.067 11.7 0.0 0.1 11.1 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme Ribosomal_L16 PF00252.18 EMD64318.1 - 2.7e-32 111.6 0.1 3.6e-32 111.1 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e RFC1 PF08519.12 EMD64319.1 - 8.4e-60 201.5 0.6 2.9e-59 199.7 0.2 2.0 2 0 0 2 2 2 1 Replication factor RFC1 C terminal domain BRCT PF00533.26 EMD64319.1 - 1.5e-14 54.1 0.0 4.1e-14 52.7 0.0 1.9 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain AAA PF00004.29 EMD64319.1 - 1.4e-09 38.4 0.0 5e-09 36.7 0.0 2.0 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 EMD64319.1 - 3.5e-06 27.1 0.0 8.5e-06 25.8 0.0 1.6 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_22 PF13401.6 EMD64319.1 - 0.0023 18.2 0.0 0.013 15.7 0.0 2.3 2 1 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EMD64319.1 - 0.0024 18.1 0.4 0.0082 16.3 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EMD64319.1 - 0.0033 17.8 2.1 0.0091 16.4 0.1 2.8 2 1 0 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 EMD64319.1 - 0.0065 16.2 0.0 0.015 15.0 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 EMD64319.1 - 0.016 15.7 0.0 0.065 13.8 0.0 2.1 1 0 0 1 1 1 0 AAA domain PTCB-BRCT PF12738.7 EMD64319.1 - 0.024 14.6 0.0 0.054 13.5 0.0 1.7 1 0 0 1 1 1 0 twin BRCT domain AAA_28 PF13521.6 EMD64319.1 - 0.028 14.7 2.0 0.097 12.9 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.6 EMD64319.1 - 0.03 14.4 0.0 0.085 12.9 0.0 1.8 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 EMD64319.1 - 0.077 12.9 0.0 0.97 9.3 0.0 2.4 2 0 0 2 2 2 0 NACHT domain NTPase_1 PF03266.15 EMD64319.1 - 0.28 11.1 1.7 0.79 9.6 0.0 2.4 3 0 0 3 3 3 0 NTPase 5_nucleotid_C PF02872.18 EMD64320.1 - 1.9e-35 122.4 0.3 4.4e-35 121.2 0.3 1.6 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Metallophos PF00149.28 EMD64320.1 - 1.4e-08 35.5 1.4 2.3e-08 34.8 0.6 1.8 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase YmdB PF13277.6 EMD64320.1 - 0.0058 16.0 0.1 0.0099 15.2 0.1 1.3 1 0 0 1 1 1 1 YmdB-like protein Glyco_hydro2_C5 PF18565.1 EMD64322.1 - 1.5e-30 105.1 0.6 2.7e-30 104.3 0.1 1.8 2 0 0 2 2 2 1 Glycoside hydrolase family 2 C-terminal domain 5 Glyco_hydro_2_C PF02836.17 EMD64322.1 - 2e-28 99.4 0.1 5e-28 98.1 0.0 1.6 2 0 0 2 2 2 1 Glycosyl hydrolases family 2, TIM barrel domain DUF4982 PF16355.5 EMD64322.1 - 4.8e-22 77.7 0.3 1.5e-21 76.0 0.3 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4982) Glyco_hydro_2_N PF02837.18 EMD64322.1 - 1.2e-19 70.9 0.0 3.4e-19 69.4 0.0 1.9 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2 PF00703.21 EMD64322.1 - 4.8e-15 56.2 1.6 4.8e-15 56.2 1.6 2.0 2 0 0 2 2 2 1 Glycosyl hydrolases family 2 BetaGal_dom4_5 PF13364.6 EMD64322.1 - 0.00075 20.1 0.0 0.015 15.9 0.0 2.6 2 0 0 2 2 2 1 Beta-galactosidase jelly roll domain SoxY PF13501.6 EMD64322.1 - 0.015 15.5 0.7 0.052 13.8 0.4 2.1 2 0 0 2 2 2 0 Sulfur oxidation protein SoxY Kelch_3 PF13415.6 EMD64322.1 - 0.069 13.5 0.0 0.24 11.7 0.0 2.1 1 0 0 1 1 1 0 Galactose oxidase, central domain Invasin_D3 PF09134.10 EMD64322.1 - 0.098 13.0 13.4 0.046 14.0 2.9 3.9 3 1 0 3 3 3 0 Invasin, domain 3 ArfGap PF01412.18 EMD64324.1 - 4.7e-40 136.3 0.6 8.6e-40 135.5 0.6 1.4 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf LIM_bind PF01803.16 EMD64325.1 - 9.9 5.6 6.4 5.2 6.5 0.6 2.1 2 0 0 2 2 2 0 LIM-domain binding protein SPOC PF07744.13 EMD64326.1 - 1.8e-19 70.1 0.0 3e-19 69.4 0.0 1.4 1 0 0 1 1 1 1 SPOC domain TFIIS_M PF07500.14 EMD64326.1 - 1.5e-18 67.3 0.2 2.7e-18 66.5 0.2 1.4 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS), central domain PHD PF00628.29 EMD64326.1 - 2e-08 34.0 11.5 3.7e-08 33.1 11.5 1.5 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 EMD64326.1 - 1.3 8.7 6.3 2.4 7.8 6.3 1.4 1 0 0 1 1 1 0 PHD-finger Proteasome PF00227.26 EMD64328.1 - 8.3e-61 204.8 0.1 1e-60 204.5 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EMD64328.1 - 4e-13 48.8 0.1 8.8e-13 47.7 0.1 1.6 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature DUF5624 PF18538.1 EMD64328.1 - 0.012 15.7 0.1 0.032 14.3 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5624) Nitrate_red_gam PF02665.14 EMD64328.1 - 0.018 14.6 0.0 0.026 14.1 0.0 1.2 1 0 0 1 1 1 0 Nitrate reductase gamma subunit FF PF01846.19 EMD64329.1 - 1.7e-15 56.9 6.3 3.9e-12 46.1 0.0 3.8 4 0 0 4 4 4 2 FF domain WW PF00397.26 EMD64329.1 - 7.4e-11 42.0 9.3 3.1e-09 36.8 4.2 2.6 2 0 0 2 2 2 2 WW domain TFIIA PF03153.13 EMD64329.1 - 0.0016 18.6 8.9 0.0016 18.6 8.9 1.9 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit MFS_1 PF07690.16 EMD64330.1 - 5.5e-36 124.2 34.9 5.5e-36 124.2 34.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EMD64330.1 - 1.1e-11 44.0 0.9 1.1e-11 44.0 0.9 1.5 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EMD64330.1 - 3.4e-09 36.1 10.1 3.4e-09 36.1 10.1 2.4 2 0 0 2 2 2 1 Sugar (and other) transporter BSP_II PF05432.11 EMD64330.1 - 0.077 12.7 1.2 0.11 12.2 1.2 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) PAS PF00989.25 EMD64331.1 - 0.00011 22.2 0.0 0.00023 21.2 0.0 1.5 1 0 0 1 1 1 1 PAS fold Zn_clus PF00172.18 EMD64331.1 - 0.0051 16.9 8.7 0.01 15.9 8.7 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Flavokinase PF01687.17 EMD64332.1 - 2.9e-33 114.5 0.0 3.9e-33 114.1 0.0 1.1 1 0 0 1 1 1 1 Riboflavin kinase Aldo_ket_red PF00248.21 EMD64333.1 - 8.6e-16 58.0 0.0 1.6e-15 57.1 0.0 1.3 1 1 0 1 1 1 1 Aldo/keto reductase family FAD_binding_1 PF00667.20 EMD64335.1 - 6.2e-62 209.1 0.0 1.2e-61 208.1 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.21 EMD64335.1 - 3.3e-10 40.6 0.0 1.1e-09 38.8 0.0 1.9 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain POR PF01558.18 EMD64335.1 - 5.5e-07 29.8 0.0 1.3e-06 28.6 0.0 1.6 1 0 0 1 1 1 1 Pyruvate ferredoxin/flavodoxin oxidoreductase PFOR_II PF17147.4 EMD64335.1 - 8.8e-06 26.0 0.1 2.5e-05 24.5 0.1 1.8 1 0 0 1 1 1 1 Pyruvate:ferredoxin oxidoreductase core domain II Transketolase_C PF02780.20 EMD64335.1 - 0.06 13.2 0.1 0.18 11.7 0.1 1.8 1 0 0 1 1 1 0 Transketolase, C-terminal domain FAD_binding_6 PF00970.24 EMD64335.1 - 0.17 12.2 0.0 1 9.7 0.0 2.3 2 0 0 2 2 2 0 Oxidoreductase FAD-binding domain Glyoxalase PF00903.25 EMD64337.1 - 7.3e-38 129.6 0.2 1.2e-18 67.6 0.1 2.1 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 EMD64337.1 - 7.1e-16 58.4 0.1 2.5e-06 27.7 0.0 4.3 2 2 2 4 4 4 3 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.7 EMD64337.1 - 1.6e-06 28.1 0.9 0.54 10.2 0.0 4.1 4 0 0 4 4 4 2 Glyoxalase-like domain Glyoxalase_6 PF18029.1 EMD64337.1 - 2.1e-06 28.5 0.0 0.12 13.1 0.0 2.9 2 2 0 2 2 2 2 Glyoxalase-like domain Glyoxalase_3 PF13468.6 EMD64337.1 - 3.1e-06 27.4 0.0 0.18 11.9 0.0 3.1 2 1 1 3 3 3 3 Glyoxalase-like domain CppA_N PF14506.6 EMD64337.1 - 0.0033 17.5 0.1 1.3 9.1 0.0 2.5 2 0 0 2 2 2 2 CppA N-terminal MoaF PF10703.9 EMD64337.1 - 0.021 14.8 0.0 3.2 7.7 0.0 2.3 2 0 0 2 2 2 0 MoaF N-terminal domain NIL PF09383.10 EMD64337.1 - 0.032 14.1 0.0 4.6 7.2 0.0 2.4 2 0 0 2 2 2 0 NIL domain DUF1338 PF07063.13 EMD64337.1 - 0.1 11.7 0.0 4.4 6.4 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF1338) 2-Hacid_dh_C PF02826.19 EMD64338.1 - 8.7e-58 194.6 0.1 2.2e-57 193.3 0.1 1.7 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EMD64338.1 - 3.9e-37 126.9 0.4 7.2e-37 126.0 0.4 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain XdhC_C PF13478.6 EMD64338.1 - 0.0072 16.8 0.0 0.02 15.4 0.0 1.8 1 0 0 1 1 1 1 XdhC Rossmann domain AdoHcyase_NAD PF00670.21 EMD64338.1 - 0.081 13.0 0.7 0.55 10.3 0.1 2.2 2 0 0 2 2 2 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain AIB PF15334.6 EMD64338.1 - 0.17 11.2 0.5 0.27 10.5 0.5 1.2 1 0 0 1 1 1 0 Aurora kinase A and ninein interacting protein HutP PF09021.11 EMD64338.1 - 0.27 11.5 4.5 1.7 9.0 4.5 2.3 1 1 0 1 1 1 0 HutP DUF4470 PF14737.6 EMD64339.1 - 3.4e-24 84.9 0.1 6.6e-24 83.9 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4470) zf-MYND PF01753.18 EMD64339.1 - 5.3e-06 26.4 9.1 1.4e-05 25.1 9.1 1.7 1 0 0 1 1 1 1 MYND finger zf-C6H2 PF15801.5 EMD64339.1 - 1.9 8.9 7.1 0.53 10.6 3.8 1.8 2 0 0 2 2 2 0 zf-MYND-like zinc finger, mRNA-binding HIM1 PF08732.10 EMD64340.1 - 1.8e-11 43.8 0.0 2.7e-11 43.3 0.0 1.2 1 0 0 1 1 1 1 HIM1 NAD_binding_10 PF13460.6 EMD64340.1 - 0.00018 21.4 0.0 0.0003 20.8 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EMD64340.1 - 0.00062 19.3 0.0 0.0018 17.8 0.0 1.9 1 1 1 2 2 2 1 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.24 EMD64340.1 - 0.00074 20.0 0.0 0.0037 17.7 0.0 2.0 1 1 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain NAD_binding_4 PF07993.12 EMD64340.1 - 0.0029 16.8 0.0 0.6 9.2 0.0 2.2 1 1 0 2 2 2 2 Male sterility protein MOSC PF03473.17 EMD64342.1 - 1.1e-22 80.4 0.0 2.9e-22 79.1 0.0 1.7 1 0 0 1 1 1 1 MOSC domain Fer2 PF00111.27 EMD64342.1 - 5.8e-12 45.4 2.3 1.4e-11 44.2 2.3 1.6 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain 3-alpha PF03475.14 EMD64342.1 - 3e-06 27.0 0.0 5.4e-06 26.2 0.0 1.4 1 0 0 1 1 1 1 3-alpha domain FAD_binding_6 PF00970.24 EMD64342.1 - 0.0023 18.2 0.0 0.0058 17.0 0.0 1.7 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 EMD64342.1 - 0.0043 17.7 0.0 0.95 10.1 0.0 2.6 1 1 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 EMD64342.1 - 0.01 16.0 0.0 1.1 9.4 0.0 2.4 1 1 0 2 2 2 0 Ferric reductase NAD binding domain Exonuc_VII_L PF02601.15 EMD64344.1 - 0.036 13.6 3.3 0.042 13.4 3.3 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit FAA_hydro_N_2 PF18288.1 EMD64345.1 - 0.13 12.6 0.1 0.62 10.5 0.0 2.1 2 0 0 2 2 2 0 Fumarylacetoacetase N-terminal domain 2 GFA PF04828.14 EMD64347.1 - 2.4e-08 34.2 0.1 2.4e-08 34.2 0.1 1.5 2 0 0 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme Abhydrolase_3 PF07859.13 EMD64348.1 - 7.6e-27 94.5 0.0 1.1e-26 94.0 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 EMD64348.1 - 1.7e-13 50.2 0.0 4.8e-13 48.7 0.0 1.7 2 0 0 2 2 2 1 Steryl acetyl hydrolase DUF3089 PF11288.8 EMD64348.1 - 0.021 14.4 0.0 0.034 13.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3089) Abhydrolase_1 PF00561.20 EMD64349.1 - 2.3e-15 57.0 0.5 3.5e-15 56.4 0.5 1.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EMD64349.1 - 1.2e-08 35.9 1.5 1.8e-08 35.3 1.5 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EMD64349.1 - 3.3e-07 29.8 0.0 5.1e-07 29.2 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Ndr PF03096.14 EMD64349.1 - 0.12 11.0 0.0 0.16 10.6 0.0 1.1 1 0 0 1 1 1 0 Ndr family TrkH PF02386.16 EMD64350.1 - 2e-119 399.3 5.0 9.1e-119 397.1 1.9 2.0 2 0 0 2 2 2 2 Cation transport protein Tim17 PF02466.19 EMD64353.1 - 6.7e-32 110.2 6.8 8.3e-32 109.9 6.8 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Phage_holin_3_3 PF16083.5 EMD64353.1 - 0.072 13.2 5.9 0.13 12.4 0.6 2.3 2 0 0 2 2 2 0 LydA holin phage, holin superfamily III Dynamin_M PF01031.20 EMD64354.1 - 1e-27 97.1 1.1 1.3e-22 80.3 0.1 2.2 2 0 0 2 2 2 2 Dynamin central region Dynamin_N PF00350.23 EMD64354.1 - 1.8e-06 28.2 0.0 7e-06 26.2 0.0 2.1 1 0 0 1 1 1 1 Dynamin family GED PF02212.18 EMD64354.1 - 0.013 15.7 0.3 0.043 14.0 0.0 2.1 2 0 0 2 2 2 0 Dynamin GTPase effector domain Abhydrolase_3 PF07859.13 EMD64355.1 - 7.4e-15 55.4 0.1 2.2e-14 53.8 0.0 1.7 2 0 0 2 2 2 1 alpha/beta hydrolase fold RNA_POL_M_15KD PF02150.16 EMD64356.1 - 1.1 9.2 0.0 1.1 9.2 0.0 2.5 2 1 1 3 3 3 0 RNA polymerases M/15 Kd subunit Gly_transf_sug PF04488.15 EMD64357.1 - 4.1e-09 37.0 0.0 9e-09 35.9 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif TcdA_TcdB PF12919.7 EMD64357.1 - 0.034 13.5 0.2 0.065 12.5 0.2 1.4 1 0 0 1 1 1 0 TcdA/TcdB catalytic glycosyltransferase domain Caps_synth PF05704.12 EMD64357.1 - 0.047 13.1 0.0 0.07 12.5 0.0 1.2 1 0 0 1 1 1 0 Capsular polysaccharide synthesis protein GBV-C_env PF12786.7 EMD64358.1 - 0.015 14.0 0.1 0.017 13.8 0.1 1.0 1 0 0 1 1 1 0 GB virus C genotype envelope VHS PF00790.19 EMD64359.1 - 6.3e-41 139.5 0.0 6.3e-41 139.5 0.0 2.2 2 0 0 2 2 2 1 VHS domain FYVE PF01363.21 EMD64359.1 - 2.5e-17 62.8 4.2 5.4e-17 61.7 4.2 1.6 1 0 0 1 1 1 1 FYVE zinc finger GAT PF03127.14 EMD64359.1 - 1.9e-05 24.9 0.0 5.6e-05 23.4 0.0 1.9 1 0 0 1 1 1 1 GAT domain UIM PF02809.20 EMD64359.1 - 0.00014 21.5 21.4 0.0086 15.9 1.9 3.6 3 0 0 3 3 3 2 Ubiquitin interaction motif FYVE_2 PF02318.16 EMD64359.1 - 0.0015 18.7 0.6 0.0034 17.6 0.6 1.5 1 0 0 1 1 1 1 FYVE-type zinc finger UCH PF00443.29 EMD64360.1 - 1.4e-52 178.8 0.0 2.1e-52 178.2 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EMD64360.1 - 1.3e-15 57.8 0.0 2.3e-15 57.0 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase USP8_dimer PF08969.11 EMD64360.1 - 0.00021 21.5 0.8 0.015 15.4 0.3 2.8 2 0 0 2 2 2 1 USP8 dimerisation domain Rhodanese PF00581.20 EMD64360.1 - 0.0017 18.8 0.0 0.0081 16.7 0.0 2.2 2 0 0 2 2 2 1 Rhodanese-like domain zf-MIZ PF02891.20 EMD64360.1 - 0.23 11.3 1.4 0.47 10.3 1.4 1.5 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger Rubredoxin_2 PF18073.1 EMD64360.1 - 1.8 8.4 4.0 7.5 6.4 0.3 2.5 2 0 0 2 2 2 0 Rubredoxin metal binding domain Arginosuc_synth PF00764.19 EMD64361.1 - 4.6e-152 506.8 0.0 5.3e-152 506.6 0.0 1.0 1 0 0 1 1 1 1 Arginosuccinate synthase QueC PF06508.13 EMD64361.1 - 0.009 15.5 0.0 0.014 14.9 0.0 1.3 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC DHHC PF01529.20 EMD64362.1 - 0.82 9.8 5.8 0.43 10.7 0.5 2.4 3 0 0 3 3 3 0 DHHC palmitoyltransferase VIT PF08487.10 EMD64363.1 - 7.9e-33 113.0 0.2 1.8e-32 111.8 0.2 1.7 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VWA_3 PF13768.6 EMD64363.1 - 8.2e-26 90.8 0.0 1.6e-25 89.9 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VIT_2 PF13757.6 EMD64363.1 - 5.9e-15 54.9 0.1 1.5e-14 53.7 0.1 1.6 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VWA_2 PF13519.6 EMD64363.1 - 1.3e-09 38.6 0.0 6.4e-09 36.4 0.0 2.2 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA PF00092.28 EMD64363.1 - 6.9e-08 32.9 0.0 1.2e-07 32.1 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_CoxE PF05762.14 EMD64363.1 - 0.00038 19.9 0.0 0.00081 18.8 0.0 1.4 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein Ribosomal_60s PF00428.19 EMD64363.1 - 0.0012 19.4 0.1 0.0012 19.4 0.1 3.1 3 0 0 3 3 3 1 60s Acidic ribosomal protein DUF2201 PF09967.9 EMD64363.1 - 0.0033 17.6 0.0 0.012 15.7 0.0 2.0 1 1 0 1 1 1 1 VWA-like domain (DUF2201) zf_Hakai PF18408.1 EMD64363.1 - 0.25 11.1 4.6 0.092 12.5 0.4 2.5 3 0 0 3 3 3 0 C2H2 Hakai zinc finger domain DUF21 PF01595.20 EMD64364.1 - 2.5e-32 112.0 0.0 3.9e-32 111.4 0.0 1.3 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain CBS PF00571.28 EMD64364.1 - 1.3e-05 25.6 0.2 0.079 13.4 0.0 2.9 3 0 0 3 3 3 2 CBS domain Transket_pyr PF02779.24 EMD64365.1 - 8.2e-43 146.1 0.0 1.3e-42 145.4 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 EMD64365.1 - 1.9e-34 118.2 0.2 2.8e-33 114.5 0.2 2.2 2 0 0 2 2 2 1 Transketolase, C-terminal domain PFOR_II PF17147.4 EMD64365.1 - 0.00099 19.4 0.0 0.0028 17.9 0.0 1.7 2 0 0 2 2 2 1 Pyruvate:ferredoxin oxidoreductase core domain II OsmC PF02566.19 EMD64366.1 - 6.2e-16 58.7 0.0 9.9e-16 58.1 0.0 1.3 1 0 0 1 1 1 1 OsmC-like protein CPSase_L_D2 PF02786.17 EMD64367.1 - 8.6e-58 195.3 0.0 1.4e-57 194.7 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_C PF02785.19 EMD64367.1 - 1.8e-31 108.5 0.0 3.8e-31 107.4 0.0 1.6 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain Biotin_carb_N PF00289.22 EMD64367.1 - 1.8e-28 99.3 0.1 1.1e-27 96.7 0.0 2.4 3 0 0 3 3 2 1 Biotin carboxylase, N-terminal domain Biotin_lipoyl PF00364.22 EMD64367.1 - 6.2e-13 48.4 3.6 7.6e-13 48.1 2.0 2.0 2 0 0 2 2 2 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.13 EMD64367.1 - 1e-09 38.2 0.0 2e-09 37.3 0.0 1.4 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 EMD64367.1 - 8.6e-07 28.7 0.0 1.7e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.14 EMD64367.1 - 3.7e-06 27.1 0.0 6.4e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain Biotin_lipoyl_2 PF13533.6 EMD64367.1 - 5.2e-06 26.2 0.2 5.2e-06 26.2 0.2 2.5 2 1 1 3 3 3 1 Biotin-lipoyl like ATPgrasp_ST PF14397.6 EMD64367.1 - 0.0028 17.0 0.0 0.0059 15.9 0.0 1.4 1 0 0 1 1 1 1 Sugar-transfer associated ATP-grasp RimK PF08443.11 EMD64367.1 - 0.0074 15.9 0.0 0.12 11.9 0.0 2.3 2 0 0 2 2 2 1 RimK-like ATP-grasp domain DUF2118 PF09891.9 EMD64367.1 - 0.011 15.8 0.3 0.025 14.5 0.3 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2118) Carboxyl_trans PF01039.22 EMD64368.1 - 2.5e-77 260.6 0.0 3.2e-77 260.3 0.0 1.1 1 0 0 1 1 1 1 Carboxyl transferase domain F_bP_aldolase PF01116.20 EMD64369.1 - 3.7e-75 253.0 0.1 4.1e-75 252.8 0.1 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II CobS PF02654.15 EMD64369.1 - 0.039 14.1 0.7 0.092 12.9 0.0 1.8 2 0 0 2 2 2 0 Cobalamin-5-phosphate synthase Fungal_trans_2 PF11951.8 EMD64370.1 - 1.2e-08 34.2 0.3 1e-07 31.1 0.2 2.1 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD64370.1 - 1.3e-07 31.7 10.7 1.3e-07 31.7 10.7 1.7 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain adh_short_C2 PF13561.6 EMD64371.1 - 2e-51 174.8 0.0 2.6e-51 174.4 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EMD64371.1 - 2.7e-45 154.2 0.0 3.2e-45 154.0 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EMD64371.1 - 1.5e-09 38.0 0.1 2.8e-09 37.2 0.1 1.5 1 1 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EMD64371.1 - 0.0092 15.2 0.0 0.011 14.9 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.19 EMD64371.1 - 0.038 13.0 0.0 0.048 12.7 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family MFS_1 PF07690.16 EMD64372.1 - 2e-35 122.4 36.3 2e-35 122.4 36.3 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily DUF5082 PF16888.5 EMD64373.1 - 0.095 13.0 0.9 5.3 7.3 0.3 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF5082) PMC2NT PF08066.12 EMD64373.1 - 0.13 12.9 0.2 3.1 8.6 0.2 2.1 1 1 0 1 1 1 0 PMC2NT (NUC016) domain DUF2959 PF11172.8 EMD64373.1 - 0.15 12.1 0.1 0.22 11.6 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2959) DUF2076 PF09849.9 EMD64373.1 - 0.76 9.8 37.9 0.011 15.7 14.2 2.2 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2076) BUD22 PF09073.10 EMD64374.1 - 1.1e-81 275.4 35.9 1.3e-81 275.2 35.9 1.0 1 0 0 1 1 1 1 BUD22 bZIP_1 PF00170.21 EMD64375.1 - 0.014 15.4 0.3 0.014 15.4 0.3 1.7 2 0 0 2 2 2 0 bZIP transcription factor DDE_3 PF13358.6 EMD64376.1 - 8e-06 25.7 1.0 8e-06 25.7 1.0 1.4 2 0 0 2 2 2 1 DDE superfamily endonuclease AA_permease PF00324.21 EMD64377.1 - 8.9e-128 426.9 43.1 1e-127 426.7 43.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EMD64377.1 - 2.4e-38 132.1 51.3 2.9e-38 131.8 51.3 1.1 1 0 0 1 1 1 1 Amino acid permease PrgI PF12666.7 EMD64377.1 - 0.055 14.2 0.7 0.055 14.2 0.7 4.7 5 0 0 5 5 5 0 PrgI family protein CHRD PF07452.12 EMD64378.1 - 1e-11 45.8 0.7 1.6e-11 45.2 0.2 1.5 1 1 1 2 2 2 1 CHRD domain Peptidase_S9 PF00326.21 EMD64381.1 - 1.6e-06 27.8 0.9 6.5e-05 22.5 0.9 2.3 1 1 1 2 2 2 1 Prolyl oligopeptidase family Esterase_phd PF10503.9 EMD64381.1 - 3.4e-06 26.7 0.0 4.4e-06 26.3 0.0 1.2 1 0 0 1 1 1 1 Esterase PHB depolymerase Abhydrolase_2 PF02230.16 EMD64381.1 - 0.00078 19.3 0.0 0.0013 18.5 0.0 1.3 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Esterase PF00756.20 EMD64381.1 - 0.014 15.1 0.1 0.015 14.9 0.1 1.2 1 0 0 1 1 1 0 Putative esterase AXE1 PF05448.12 EMD64381.1 - 0.067 11.9 0.1 0.13 10.9 0.1 1.3 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) Hydrolase_4 PF12146.8 EMD64381.1 - 0.16 11.2 0.1 5.1 6.3 0.1 2.1 1 1 1 2 2 2 0 Serine aminopeptidase, S33 Glyco_hydro_92 PF07971.12 EMD64382.1 - 2.6e-132 442.0 1.7 3.1e-132 441.8 1.7 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 Glyco_hydro_92N PF17678.1 EMD64382.1 - 6.4e-51 173.6 3.2 9.6e-51 173.0 3.2 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 N-terminal domain DUF1664 PF07889.12 EMD64384.1 - 0.0009 19.3 0.3 0.048 13.7 0.1 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF1664) HALZ PF02183.18 EMD64384.1 - 0.003 17.7 0.7 0.087 13.1 0.2 2.4 2 0 0 2 2 2 1 Homeobox associated leucine zipper BRE1 PF08647.11 EMD64384.1 - 0.0031 17.5 1.5 0.44 10.7 0.0 2.4 2 0 0 2 2 2 1 BRE1 E3 ubiquitin ligase Fungal_TACC PF12709.7 EMD64384.1 - 0.0073 16.7 0.9 0.066 13.7 0.1 2.4 2 0 0 2 2 2 1 Fungal Transforming acidic coiled-coil (TACC) proteins Fez1 PF06818.15 EMD64384.1 - 0.013 16.0 1.4 0.023 15.2 1.3 1.4 1 1 0 1 1 1 0 Fez1 RPW8 PF05659.11 EMD64384.1 - 0.02 14.6 0.5 0.66 9.7 0.0 2.7 2 1 0 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 DUF913 PF06025.12 EMD64384.1 - 0.035 13.1 0.5 0.065 12.2 0.2 1.5 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) DNA_photolyase PF00875.18 EMD64384.1 - 0.036 14.1 0.1 0.073 13.1 0.1 1.5 1 1 0 1 1 1 0 DNA photolyase FlaC_arch PF05377.11 EMD64384.1 - 0.042 14.2 0.6 9.9 6.6 0.0 3.2 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) CENP-F_leu_zip PF10473.9 EMD64384.1 - 0.043 13.8 4.5 0.75 9.8 0.5 2.2 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 HMMR_N PF15905.5 EMD64384.1 - 0.044 13.3 0.5 0.065 12.7 0.5 1.2 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal DUF5582 PF17819.1 EMD64384.1 - 0.09 13.2 0.0 0.17 12.3 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5582) EzrA PF06160.12 EMD64384.1 - 0.094 10.9 5.6 1.5 6.9 0.1 2.1 1 1 0 2 2 2 0 Septation ring formation regulator, EzrA DUF948 PF06103.11 EMD64384.1 - 0.1 12.9 0.4 0.43 10.9 0.0 2.2 3 0 0 3 3 1 0 Bacterial protein of unknown function (DUF948) bZIP_1 PF00170.21 EMD64384.1 - 0.21 11.7 1.2 0.45 10.6 0.3 1.9 2 0 0 2 2 2 0 bZIP transcription factor APG6_N PF17675.1 EMD64384.1 - 0.65 10.5 5.6 0.66 10.5 1.5 2.1 2 0 0 2 2 2 0 Apg6 coiled-coil region DUF4472 PF14739.6 EMD64384.1 - 1.3 9.8 4.1 23 5.8 0.1 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4472) YrhK PF14145.6 EMD64385.1 - 0.00062 19.6 4.0 0.00062 19.6 4.0 4.9 4 1 1 5 5 5 2 YrhK-like protein Glyco_hydro_3_C PF01915.22 EMD64387.1 - 2.8e-33 115.6 0.0 4.6e-33 114.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 EMD64387.1 - 1.2e-26 93.9 0.0 1.8e-26 93.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Melibiase_2 PF16499.5 EMD64388.1 - 1.8e-49 168.4 2.5 1.2e-48 165.8 1.3 2.3 2 0 0 2 2 2 1 Alpha galactosidase A Mannosidase_ig PF17786.1 EMD64388.1 - 2.5e-17 63.3 0.3 8.2e-17 61.6 0.1 2.1 2 0 0 2 2 2 1 Mannosidase Ig/CBM-like domain Melibiase_C PF17801.1 EMD64388.1 - 3e-08 33.6 6.7 3.8e-08 33.3 1.3 3.3 2 0 0 2 2 2 1 Alpha galactosidase C-terminal beta sandwich domain Ig_mannosidase PF17753.1 EMD64388.1 - 0.00012 21.8 0.1 0.00048 19.8 0.0 2.1 2 0 0 2 2 2 1 Ig-fold domain Glyco_hydro_2 PF00703.21 EMD64388.1 - 0.00016 22.3 0.0 0.00036 21.2 0.0 1.6 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 Glyco_hydro_2_C PF02836.17 EMD64388.1 - 0.055 12.6 0.0 0.098 11.8 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolases family 2, TIM barrel domain F-box PF00646.33 EMD64389.1 - 4.9e-08 32.7 0.1 7.8e-07 28.8 0.0 2.7 3 0 0 3 3 3 1 F-box domain F-box-like PF12937.7 EMD64389.1 - 6e-07 29.3 0.0 1.4e-06 28.1 0.0 1.6 1 0 0 1 1 1 1 F-box-like Ferric_reduct PF01794.19 EMD64390.1 - 1.8e-23 83.0 9.0 3.5e-23 82.1 9.0 1.5 1 0 0 1 1 1 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 EMD64390.1 - 4.3e-18 65.9 0.0 6.4e-18 65.4 0.0 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EMD64390.1 - 6.4e-12 45.5 0.0 1.2e-11 44.7 0.0 1.4 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_1 PF00175.21 EMD64390.1 - 1.8e-05 25.3 0.0 0.00012 22.7 0.0 2.2 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain Ctr PF04145.15 EMD64391.1 - 6.7e-39 133.9 2.4 8.4e-39 133.5 2.4 1.1 1 0 0 1 1 1 1 Ctr copper transporter family DUF3040 PF11239.8 EMD64391.1 - 0.021 15.1 3.6 0.025 14.8 1.1 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF3040) OSTbeta PF15048.6 EMD64391.1 - 0.036 14.2 0.1 0.065 13.4 0.1 1.4 1 0 0 1 1 1 0 Organic solute transporter subunit beta protein tRNA_NucTran2_2 PF13735.6 EMD64392.1 - 0.052 13.5 0.2 0.14 12.1 0.2 1.7 1 0 0 1 1 1 0 tRNA nucleotidyltransferase domain 2 putative FliE PF02049.18 EMD64392.1 - 0.34 11.1 1.9 1.5 9.0 1.4 2.2 1 1 1 2 2 2 0 Flagellar hook-basal body complex protein FliE Cutinase PF01083.22 EMD64394.1 - 4.3e-27 95.2 0.8 7.2e-27 94.5 0.8 1.4 1 0 0 1 1 1 1 Cutinase PE-PPE PF08237.11 EMD64394.1 - 0.00018 21.2 1.8 0.00099 18.7 0.0 2.6 3 0 0 3 3 3 1 PE-PPE domain MFS_1 PF07690.16 EMD64395.1 - 1e-14 54.2 60.5 2.2e-13 49.9 57.4 2.9 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 EMD64395.1 - 3e-06 26.0 20.0 4.2e-06 25.5 20.0 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Filaggrin PF03516.13 EMD64395.1 - 0.2 12.4 0.4 0.38 11.5 0.4 1.4 1 0 0 1 1 1 0 Filaggrin DUF4267 PF14087.6 EMD64395.1 - 1.3 9.2 8.5 6.4 6.9 0.3 3.4 3 1 0 3 3 3 0 Domain of unknown function (DUF4267) Fungal_trans PF04082.18 EMD64396.1 - 1.4e-11 44.0 0.7 2.3e-11 43.2 0.2 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD64396.1 - 5.2e-08 32.9 9.2 9.4e-08 32.1 9.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF3295 PF11702.8 EMD64399.1 - 9.2e-151 503.6 33.9 1.3e-150 503.1 33.9 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3295) DUF1752 PF08550.10 EMD64399.1 - 4.5e-09 36.0 1.0 8.9e-09 35.0 1.0 1.5 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) RNA_pol_Rpb1_1 PF04997.12 EMD64399.1 - 0.059 12.7 0.0 0.1 11.9 0.0 1.3 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 1 DNA_pol_phi PF04931.13 EMD64399.1 - 1.7 6.7 9.9 2.4 6.1 9.9 1.1 1 0 0 1 1 1 0 DNA polymerase phi CENP-B_dimeris PF09026.10 EMD64399.1 - 2.3 8.6 12.3 4.7 7.7 12.3 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain PBP1_TM PF14812.6 EMD64399.1 - 3.4 8.1 7.4 9.8 6.6 7.4 1.8 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DDHD PF02862.17 EMD64399.1 - 9 6.4 12.5 6.2 6.9 1.8 2.8 3 0 0 3 3 3 0 DDHD domain DUF4785 PF16024.5 EMD64401.1 - 0.053 12.3 0.0 0.065 12.0 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4785) Cpn60_TCP1 PF00118.24 EMD64404.1 - 4.5e-159 530.2 4.9 5.1e-159 530.0 4.9 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Enolase_N PF03952.16 EMD64404.1 - 0.064 13.4 1.9 6.6 6.9 0.1 3.3 3 0 0 3 3 3 0 Enolase, N-terminal domain Chromo_shadow PF01393.19 EMD64405.1 - 3.1e-19 68.8 0.7 7.8e-18 64.3 0.4 2.2 2 0 0 2 2 2 1 Chromo shadow domain Chromo PF00385.24 EMD64405.1 - 3.2e-10 39.7 1.2 5.5e-10 39.0 0.2 1.9 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain PAN_4 PF14295.6 EMD64406.1 - 0.0016 18.3 1.6 0.0034 17.3 1.6 1.5 1 0 0 1 1 1 1 PAN domain PAN_1 PF00024.26 EMD64406.1 - 0.0047 16.9 0.3 0.01 15.8 0.3 1.5 1 0 0 1 1 1 1 PAN domain FAD_binding_4 PF01565.23 EMD64408.1 - 9.9e-20 70.7 3.7 1.7e-19 69.9 2.9 1.8 2 0 0 2 2 2 1 FAD binding domain BBE PF08031.12 EMD64408.1 - 0.00017 21.6 0.1 0.00037 20.5 0.1 1.6 1 0 0 1 1 1 1 Berberine and berberine like DUF4286 PF14114.6 EMD64409.1 - 0.0043 17.5 0.3 2.1 8.9 0.0 2.8 3 0 0 3 3 3 2 Domain of unknown function (DUF4286) Oxidored_molyb PF00174.19 EMD64411.1 - 3.7e-48 163.4 0.0 6.3e-48 162.6 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain Mo-co_dimer PF03404.16 EMD64411.1 - 2.3e-17 63.3 2.7 4.7e-17 62.3 2.7 1.5 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain ACOX PF01756.19 EMD64412.1 - 5.3e-51 172.7 0.1 1.2e-50 171.6 0.0 1.6 2 0 0 2 2 2 1 Acyl-CoA oxidase Acyl-CoA_ox_N PF14749.6 EMD64412.1 - 2.8e-14 53.7 0.0 6.6e-14 52.5 0.0 1.7 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_M PF02770.19 EMD64412.1 - 9.4e-10 38.6 0.0 2.1e-09 37.5 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.24 EMD64412.1 - 0.0026 18.0 0.1 0.0078 16.4 0.1 1.9 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain SIS PF01380.22 EMD64413.1 - 7.5e-14 51.7 0.1 1.4e-13 50.8 0.1 1.5 1 1 0 1 1 1 1 SIS domain SIS_2 PF13580.6 EMD64413.1 - 1.7e-05 24.9 0.7 0.0033 17.4 0.3 2.4 1 1 1 2 2 2 2 SIS domain Acetyltransf_1 PF00583.25 EMD64414.1 - 1.2e-09 38.4 0.0 1.5e-09 38.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EMD64414.1 - 2.6e-07 31.0 0.0 4.6e-07 30.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EMD64414.1 - 3.6e-07 30.2 0.0 4.6e-07 29.8 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EMD64414.1 - 0.027 14.4 0.0 0.037 14.0 0.0 1.2 1 0 0 1 1 1 0 FR47-like protein Amino_oxidase PF01593.24 EMD64415.1 - 2e-44 152.6 0.0 3.1e-43 148.7 0.0 2.5 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EMD64415.1 - 9.7e-08 32.1 0.0 4.4e-07 30.0 0.0 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EMD64415.1 - 0.0017 17.7 0.0 0.019 14.2 0.0 2.3 2 1 1 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EMD64415.1 - 0.0046 16.3 0.1 0.0081 15.5 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.27 EMD64415.1 - 0.12 13.0 0.1 0.25 11.9 0.1 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Ribonuc_L-PSP PF01042.21 EMD64416.1 - 4.9e-31 107.3 0.0 6.7e-31 106.8 0.0 1.2 1 0 0 1 1 1 1 Endoribonuclease L-PSP NACHT_N PF17100.5 EMD64417.1 - 2.1e-58 197.8 0.0 3.1e-58 197.2 0.0 1.2 1 0 0 1 1 1 1 N-terminal domain of NWD NACHT-NTPase WD40 PF00400.32 EMD64417.1 - 7e-05 23.5 4.5 9.3e-05 23.1 0.8 2.9 2 1 0 2 2 2 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD64417.1 - 0.0087 16.3 0.0 0.018 15.4 0.0 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EMD64417.1 - 0.012 14.3 0.1 0.017 13.8 0.1 1.1 1 0 0 1 1 1 0 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 EMD64417.1 - 0.085 11.8 0.1 0.23 10.4 0.1 1.6 1 1 1 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF1513 PF07433.11 EMD64417.1 - 0.11 11.5 0.1 0.23 10.5 0.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1513) Abhydrolase_1 PF00561.20 EMD64418.1 - 2.9e-16 59.9 0.0 3.8e-16 59.5 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EMD64418.1 - 4.5e-11 43.8 0.1 8.6e-11 42.8 0.1 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family EHN PF06441.12 EMD64418.1 - 0.017 15.5 0.3 0.036 14.4 0.3 1.5 1 0 0 1 1 1 0 Epoxide hydrolase N terminus Nucleotid_trans PF03407.16 EMD64420.1 - 3.5e-05 23.9 0.8 5.2e-05 23.3 0.8 1.3 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase Glyco_transf_34 PF05637.12 EMD64420.1 - 9.7e-05 22.2 2.6 0.0018 18.1 2.7 2.1 1 1 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family ABC_tran PF00005.27 EMD64422.1 - 5.6e-32 111.1 2.0 4e-20 72.7 0.0 2.9 3 0 0 3 3 3 2 ABC transporter AAA_21 PF13304.6 EMD64422.1 - 7.1e-10 39.2 4.7 0.0034 17.2 0.0 3.3 2 1 0 3 3 3 3 AAA domain, putative AbiEii toxin, Type IV TA system ABC_tran_Xtn PF12848.7 EMD64422.1 - 2.7e-08 33.7 6.0 2.7e-08 33.7 6.0 2.1 2 0 0 2 2 2 1 ABC transporter SMC_N PF02463.19 EMD64422.1 - 1.2e-07 31.5 0.1 0.0072 15.8 0.0 3.2 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain E3_UbLigase_R4 PF13764.6 EMD64422.1 - 0.73 7.9 3.0 1.2 7.2 3.0 1.2 1 0 0 1 1 1 0 E3 ubiquitin-protein ligase UBR4 zf-C2HC_2 PF13913.6 EMD64423.1 - 0.12 12.4 0.1 0.27 11.2 0.1 1.5 1 0 0 1 1 1 0 zinc-finger of a C2HC-type zf-C2H2_4 PF13894.6 EMD64423.1 - 0.19 12.7 0.1 0.19 12.7 0.1 3.2 4 0 0 4 4 4 0 C2H2-type zinc finger GCOM2 PF15328.6 EMD64423.1 - 1.9 8.8 11.9 4.3 7.7 11.9 1.6 1 0 0 1 1 1 0 Putative GRINL1B complex locus protein 2 Rtf2 PF04641.12 EMD64423.1 - 4.4 6.6 8.8 4.7 6.5 0.1 2.3 2 0 0 2 2 2 0 Rtf2 RING-finger TCO89 PF10452.9 EMD64425.1 - 8.4e-07 28.3 1.0 3.6e-05 23.0 0.0 3.6 4 0 0 4 4 4 3 TORC1 subunit TCO89 PT PF04886.12 EMD64426.1 - 8.4 6.0 18.4 22 4.7 5.2 3.2 2 1 0 2 2 2 0 PT repeat COesterase PF00135.28 EMD64427.1 - 6.3e-80 269.5 0.0 7.8e-80 269.2 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EMD64427.1 - 3.7e-07 30.2 0.0 1.2e-06 28.5 0.0 1.9 2 1 0 2 2 2 1 alpha/beta hydrolase fold Atx10homo_assoc PF09759.9 EMD64428.1 - 5.5e-29 100.1 3.4 1.7e-27 95.3 0.3 2.8 3 0 0 3 3 3 1 Spinocerebellar ataxia type 10 protein domain HMG_box PF00505.19 EMD64428.1 - 0.00022 21.6 0.1 0.00056 20.3 0.1 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EMD64428.1 - 0.00044 20.8 0.1 0.0014 19.2 0.1 1.8 1 0 0 1 1 1 1 HMG-box domain DUF4589 PF15252.6 EMD64428.1 - 0.0063 16.6 1.1 0.0063 16.6 1.1 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4589) DUF4685 PF15737.5 EMD64428.1 - 0.011 16.1 2.6 0.88 10.0 0.2 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4685) DUF4349 PF14257.6 EMD64428.1 - 0.055 12.9 3.6 0.15 11.5 0.3 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4349) TF_AP-2 PF03299.14 EMD64428.1 - 0.13 12.2 0.1 0.3 11.0 0.1 1.6 1 0 0 1 1 1 0 Transcription factor AP-2 DUF4094 PF13334.6 EMD64428.1 - 0.13 12.6 1.4 0.35 11.3 1.4 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4094) Glycohydro_20b2 PF14845.6 EMD64428.1 - 0.41 11.3 4.3 0.3 11.7 0.5 2.6 3 0 0 3 3 3 0 beta-acetyl hexosaminidase like AATF-Che1 PF13339.6 EMD64428.1 - 1.9 9.2 6.7 15 6.2 0.4 3.5 3 1 1 4 4 4 0 Apoptosis antagonizing transcription factor Prefoldin_3 PF13758.6 EMD64429.1 - 2.5e-27 94.8 1.8 7.3e-27 93.3 1.8 1.8 1 0 0 1 1 1 1 Prefoldin subunit DUF3835 PF12927.7 EMD64429.1 - 1.3e-24 86.8 0.3 1.3e-24 86.8 0.3 6.2 6 3 2 8 8 8 2 Domain of unknown function (DUF3835) LEM PF03020.15 EMD64429.1 - 0.07 12.7 0.2 2.7 7.7 0.0 3.3 3 0 0 3 3 3 0 LEM domain DUF5340 PF17275.2 EMD64429.1 - 0.25 11.5 8.7 0.99 9.6 0.8 3.1 3 0 0 3 3 3 0 Family of unknown function (DUF5340) DUF3618 PF12277.8 EMD64429.1 - 0.63 10.3 4.5 0.37 11.1 0.8 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3618) FAM219A PF15260.6 EMD64429.1 - 3.6 8.0 5.8 1.6 9.1 0.7 3.1 1 1 3 4 4 4 0 Protein family FAM219A MAT1 PF06391.13 EMD64430.1 - 1.4e-30 106.7 2.6 1.8e-30 106.3 2.6 1.1 1 0 0 1 1 1 1 CDK-activating kinase assembly factor MAT1 zf-C3HC4_5 PF17121.5 EMD64430.1 - 1.3e-21 76.2 6.7 2.1e-21 75.5 6.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EMD64430.1 - 0.00087 19.2 6.2 0.0032 17.4 2.4 2.3 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4 PF00097.25 EMD64430.1 - 0.0042 16.9 4.6 0.016 15.1 4.8 1.8 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EMD64430.1 - 0.0069 16.7 3.2 0.018 15.4 3.2 1.7 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EMD64430.1 - 0.0077 16.1 2.8 0.017 14.9 2.8 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EMD64430.1 - 0.012 15.4 4.5 0.031 14.1 4.5 1.7 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EMD64430.1 - 0.016 15.2 4.4 0.032 14.3 4.4 1.5 1 0 0 1 1 1 0 RING-type zinc-finger DUF572 PF04502.13 EMD64430.1 - 0.15 11.7 0.7 0.23 11.1 0.7 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) DUF2340 PF10209.9 EMD64430.1 - 0.21 12.1 1.7 0.54 10.7 0.3 1.9 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2340) zf-ANAPC11 PF12861.7 EMD64430.1 - 0.29 11.2 2.0 0.53 10.4 2.0 1.3 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.6 EMD64430.1 - 0.32 10.8 4.5 8.2 6.3 1.8 2.4 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain MARVEL PF01284.23 EMD64431.1 - 2.5e-07 30.8 5.8 3.5e-07 30.3 5.8 1.2 1 0 0 1 1 1 1 Membrane-associating domain DUF1129 PF06570.11 EMD64431.1 - 0.22 11.0 2.3 0.34 10.3 2.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) SUR7 PF06687.12 EMD64431.1 - 2.4 7.7 7.0 6.6 6.3 6.6 1.8 1 1 0 1 1 1 0 SUR7/PalI family RTC PF01137.21 EMD64432.1 - 6.4e-32 110.6 0.0 1.4e-31 109.4 0.0 1.5 1 1 0 1 1 1 1 RNA 3'-terminal phosphate cyclase CHASE3 PF05227.13 EMD64434.1 - 0.16 11.9 0.1 1.2 9.0 0.0 2.3 3 0 0 3 3 3 0 CHASE3 domain TauD PF02668.16 EMD64435.1 - 5.2e-24 85.5 0.0 7.4e-24 85.0 0.0 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family CsiD PF08943.10 EMD64435.1 - 0.00069 18.8 0.1 0.0011 18.1 0.1 1.2 1 0 0 1 1 1 1 CsiD TPR_12 PF13424.6 EMD64437.1 - 1.5e-71 236.7 47.9 4.9e-16 58.8 1.8 9.2 3 2 8 11 11 11 11 Tetratricopeptide repeat TPR_10 PF13374.6 EMD64437.1 - 4e-44 147.3 22.1 3.1e-07 30.0 0.1 12.8 14 0 0 14 14 14 6 Tetratricopeptide repeat TPR_1 PF00515.28 EMD64437.1 - 3.1e-14 52.1 10.2 0.016 15.0 0.1 8.1 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_2 PF07719.17 EMD64437.1 - 1.5e-13 49.7 21.9 0.17 12.0 0.5 10.0 10 0 0 10 10 10 3 Tetratricopeptide repeat TPR_MalT PF17874.1 EMD64437.1 - 1.6e-13 50.7 8.6 6.5e-05 22.5 0.6 4.6 1 1 2 4 4 4 3 MalT-like TPR region TPR_16 PF13432.6 EMD64437.1 - 3.7e-11 43.5 18.0 0.063 13.9 0.7 8.4 8 2 0 8 8 7 3 Tetratricopeptide repeat TPR_7 PF13176.6 EMD64437.1 - 3.1e-10 39.3 21.0 0.023 14.7 0.1 9.3 10 0 0 10 10 9 4 Tetratricopeptide repeat TPR_8 PF13181.6 EMD64437.1 - 4.9e-10 38.8 5.1 0.53 10.6 0.0 7.7 7 0 0 7 7 7 1 Tetratricopeptide repeat NB-ARC PF00931.22 EMD64437.1 - 5.9e-08 32.2 0.0 1e-07 31.4 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain TPR_17 PF13431.6 EMD64437.1 - 1.1e-06 28.6 6.5 35 5.1 0.0 8.6 10 0 0 10 10 8 0 Tetratricopeptide repeat TPR_19 PF14559.6 EMD64437.1 - 1.1e-05 25.9 14.9 0.1 13.1 0.2 6.5 4 2 4 8 8 8 1 Tetratricopeptide repeat AAA_22 PF13401.6 EMD64437.1 - 1.9e-05 24.9 0.0 4.8e-05 23.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain TPR_14 PF13428.6 EMD64437.1 - 6.4e-05 23.4 20.4 1.3 10.0 0.3 9.4 9 2 2 11 11 9 1 Tetratricopeptide repeat TPR_4 PF07721.14 EMD64437.1 - 0.00032 21.1 19.0 1.5 9.7 1.7 8.7 11 0 0 11 11 8 1 Tetratricopeptide repeat MIT PF04212.18 EMD64437.1 - 0.00032 20.7 0.1 1.7 8.8 0.0 4.4 3 0 0 3 3 3 1 MIT (microtubule interacting and transport) domain AAA_16 PF13191.6 EMD64437.1 - 0.00043 20.7 0.0 0.0021 18.4 0.0 2.3 1 0 0 1 1 1 1 AAA ATPase domain TPR_5 PF12688.7 EMD64437.1 - 0.014 15.6 1.6 0.28 11.5 0.1 3.0 2 1 0 2 2 2 0 Tetratrico peptide repeat ATPase_2 PF01637.18 EMD64437.1 - 0.043 13.7 0.1 0.16 11.9 0.0 1.9 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea ANAPC3 PF12895.7 EMD64437.1 - 0.045 14.0 2.0 6 7.2 0.0 4.2 4 1 0 5 5 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_3 PF07720.12 EMD64437.1 - 0.54 10.3 3.7 29 4.8 0.0 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat HET PF06985.11 EMD64439.1 - 1.3e-22 80.8 0.0 1.5e-22 80.5 0.0 1.1 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) GMC_oxred_N PF00732.19 EMD64440.1 - 1.1e-56 192.4 0.0 1.4e-56 192.1 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EMD64440.1 - 2.5e-36 125.3 0.0 4e-36 124.7 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase Lycopene_cycl PF05834.12 EMD64440.1 - 1.1e-07 31.3 0.2 5.7e-06 25.6 0.2 2.2 2 0 0 2 2 2 1 Lycopene cyclase protein Thi4 PF01946.17 EMD64440.1 - 5.7e-05 22.5 0.1 9.6e-05 21.7 0.1 1.2 1 0 0 1 1 1 1 Thi4 family Pyr_redox_3 PF13738.6 EMD64440.1 - 8.4e-05 22.0 0.2 0.27 10.5 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EMD64440.1 - 0.0003 20.9 0.5 0.00086 19.5 0.1 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EMD64440.1 - 0.00085 19.0 0.2 0.036 13.6 0.1 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EMD64440.1 - 0.0014 17.9 0.1 0.051 12.8 0.1 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EMD64440.1 - 0.0021 16.9 0.2 0.18 10.5 0.1 2.2 2 0 0 2 2 2 1 HI0933-like protein NAD_binding_9 PF13454.6 EMD64440.1 - 0.0089 16.0 0.2 0.22 11.5 0.1 2.4 2 0 0 2 2 2 1 FAD-NAD(P)-binding GIDA PF01134.22 EMD64440.1 - 0.013 14.6 0.1 1.3 8.1 0.0 2.2 2 0 0 2 2 2 0 Glucose inhibited division protein A FAD_binding_2 PF00890.24 EMD64440.1 - 0.014 14.5 0.2 0.069 12.2 0.1 1.9 2 0 0 2 2 2 0 FAD binding domain Trp_halogenase PF04820.14 EMD64440.1 - 0.056 12.3 0.0 0.092 11.6 0.0 1.3 1 0 0 1 1 1 0 Tryptophan halogenase Pyr_redox PF00070.27 EMD64440.1 - 0.17 12.5 0.0 13 6.4 0.0 2.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Putative_PNPOx PF01243.20 EMD64441.1 - 3.7e-13 49.5 0.0 1.7e-10 41.0 0.0 2.4 2 0 0 2 2 2 2 Pyridoxamine 5'-phosphate oxidase FAD_binding_6 PF00970.24 EMD64441.1 - 0.024 15.0 0.0 1.2 9.5 0.0 2.5 1 1 0 1 1 1 0 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 EMD64441.1 - 0.12 13.0 0.0 0.3 11.8 0.0 1.7 2 0 0 2 2 2 0 Oxidoreductase NAD-binding domain Hamartin PF04388.12 EMD64442.1 - 2 7.0 9.7 2.3 6.8 9.7 1.1 1 0 0 1 1 1 0 Hamartin protein SPATA3 PF15662.5 EMD64442.1 - 9.4 6.8 16.1 13 6.3 16.1 1.2 1 0 0 1 1 1 0 Spermatogenesis-associated protein 3 family GTP_EFTU PF00009.27 EMD64443.1 - 2.3e-47 161.1 0.1 5e-47 160.0 0.1 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain HBS1_N PF08938.10 EMD64443.1 - 6.8e-23 80.8 3.3 6.8e-23 80.8 3.3 2.1 2 0 0 2 2 2 1 HBS1 N-terminus GTP_EFTU_D3 PF03143.17 EMD64443.1 - 9.7e-11 42.0 0.1 2.2e-10 40.8 0.1 1.6 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain MMR_HSR1 PF01926.23 EMD64443.1 - 5.7e-08 32.8 0.1 0.00042 20.4 0.0 3.2 3 0 0 3 3 3 2 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.25 EMD64443.1 - 1.7e-06 28.3 0.0 4.4e-06 27.0 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 Roc PF08477.13 EMD64443.1 - 0.00017 21.8 0.1 0.017 15.3 0.0 2.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EMD64443.1 - 0.0035 17.0 0.3 0.031 13.9 0.0 2.3 2 0 0 2 2 2 1 Ras family SRPRB PF09439.10 EMD64443.1 - 0.0057 16.1 0.0 0.57 9.6 0.0 2.4 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Septin PF00735.18 EMD64443.1 - 0.056 12.7 0.0 0.1 11.9 0.0 1.3 1 0 0 1 1 1 0 Septin FeoB_N PF02421.18 EMD64443.1 - 0.073 12.6 0.1 1.2 8.6 0.1 2.8 2 1 0 2 2 2 0 Ferrous iron transport protein B PTPA PF03095.15 EMD64444.1 - 1.4e-121 405.6 0.0 1.7e-121 405.3 0.0 1.1 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein AT_hook PF02178.19 EMD64445.1 - 0.12 12.3 7.8 0.34 10.9 4.0 2.9 2 0 0 2 2 2 0 AT hook motif Casc1_N PF15927.5 EMD64445.1 - 0.8 9.4 10.6 2.5 7.8 10.6 1.7 1 0 0 1 1 1 0 Cancer susceptibility candidate 1 N-terminus DHR10 PF18595.1 EMD64445.1 - 1.4 9.0 10.5 1.8 8.7 6.2 2.5 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain APH PF01636.23 EMD64446.1 - 2.8e-08 34.0 0.0 0.0099 15.8 0.0 2.3 2 0 0 2 2 2 2 Phosphotransferase enzyme family Wbp11 PF09429.10 EMD64447.1 - 0.25 11.8 7.0 0.62 10.5 7.0 1.7 1 0 0 1 1 1 0 WW domain binding protein 11 DUF2433 PF10360.9 EMD64450.1 - 4e-48 162.6 0.0 6.2e-48 162.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2433) Metallophos PF00149.28 EMD64450.1 - 0.002 18.7 0.0 0.0039 17.7 0.0 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EMD64450.1 - 0.0058 16.8 0.0 0.021 15.1 0.0 1.9 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain ORC6 PF05460.13 EMD64450.1 - 6.1 6.0 6.4 9.1 5.4 6.4 1.1 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) CDC27 PF09507.10 EMD64450.1 - 7 5.9 11.2 13 5.0 11.2 1.4 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 HEAT PF02985.22 EMD64451.1 - 1.2e-17 62.5 3.8 0.00064 19.8 0.1 9.3 10 0 0 10 10 8 3 HEAT repeat HEAT_2 PF13646.6 EMD64451.1 - 7.1e-16 58.4 3.2 0.0022 18.4 0.1 7.5 6 1 1 7 7 7 4 HEAT repeats HEAT_EZ PF13513.6 EMD64451.1 - 4.3e-15 55.8 16.2 2.3e-05 24.8 0.3 9.3 11 1 1 12 12 11 4 HEAT-like repeat IBN_N PF03810.19 EMD64451.1 - 1e-10 41.4 1.5 2.6e-10 40.0 0.6 2.3 2 0 0 2 2 2 1 Importin-beta N-terminal domain Vac14_Fab1_bd PF12755.7 EMD64451.1 - 8.5e-09 35.9 0.0 0.45 11.1 0.0 5.3 4 1 1 5 5 4 3 Vacuolar 14 Fab1-binding region Arm PF00514.23 EMD64451.1 - 1.6e-08 34.3 3.4 0.8 9.8 0.0 6.3 6 0 0 6 6 6 3 Armadillo/beta-catenin-like repeat Adaptin_N PF01602.20 EMD64451.1 - 8.5e-07 27.9 0.0 0.037 12.6 0.0 4.0 4 1 1 5 5 5 2 Adaptin N terminal region RTP1_C1 PF10363.9 EMD64451.1 - 8.9e-06 25.9 0.0 0.72 10.1 0.0 4.6 4 1 1 5 5 5 3 Required for nuclear transport of RNA pol II C-terminus 1 Cnd1 PF12717.7 EMD64451.1 - 1.9e-05 24.8 0.0 0.26 11.3 0.0 4.5 5 1 0 5 5 5 2 non-SMC mitotic condensation complex subunit 1 RIX1 PF08167.12 EMD64451.1 - 2.3e-05 24.2 0.0 0.45 10.2 0.0 4.3 4 2 0 4 4 4 2 rRNA processing/ribosome biogenesis MMS19_C PF12460.8 EMD64451.1 - 2.8e-05 23.4 0.0 0.037 13.1 0.0 3.1 4 0 0 4 4 4 2 RNAPII transcription regulator C-terminal CLASP_N PF12348.8 EMD64451.1 - 0.00088 18.9 0.0 0.78 9.3 0.0 3.9 3 1 1 4 4 4 1 CLASP N terminal DUF3385 PF11865.8 EMD64451.1 - 0.0013 18.7 0.0 16 5.4 0.0 5.5 6 1 0 6 6 6 0 Domain of unknown function (DUF3385) Tti2 PF10521.9 EMD64451.1 - 0.013 15.1 0.0 0.43 10.1 0.0 3.1 3 0 0 3 3 3 0 Tti2 family DUF4042 PF13251.6 EMD64451.1 - 0.042 13.6 0.5 8.3 6.1 0.0 4.5 5 0 0 5 5 5 0 Domain of unknown function (DUF4042) IFRD PF05004.13 EMD64451.1 - 0.055 12.6 3.4 23 4.0 0.1 4.5 2 2 1 4 4 4 0 Interferon-related developmental regulator (IFRD) DRIM PF07539.12 EMD64451.1 - 0.11 10.8 1.3 6.6 4.9 0.0 3.4 2 2 0 3 3 3 0 Down-regulated in metastasis DUF3295 PF11702.8 EMD64451.1 - 8.4 5.6 6.4 13 5.0 6.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) NPC1_N PF16414.5 EMD64452.1 - 3.3e-84 282.3 9.8 6.7e-84 281.3 9.8 1.5 1 0 0 1 1 1 1 Niemann-Pick C1 N terminus Patched PF02460.18 EMD64452.1 - 3e-70 237.3 13.9 6e-69 233.0 13.9 2.4 1 1 0 1 1 1 1 Patched family Sterol-sensing PF12349.8 EMD64452.1 - 7.3e-53 178.5 5.2 7.3e-53 178.5 5.2 3.6 3 1 0 4 4 4 1 Sterol-sensing domain of SREBP cleavage-activation MMPL PF03176.15 EMD64452.1 - 2.9e-06 26.4 29.8 0.00013 21.0 8.5 2.5 2 0 0 2 2 2 2 MMPL family ACR_tran PF00873.19 EMD64452.1 - 2.7 5.5 20.0 0.085 10.5 12.9 1.8 2 0 0 2 2 2 0 AcrB/AcrD/AcrF family Aldo_ket_red PF00248.21 EMD64453.1 - 1.5e-39 136.0 0.0 3.3e-38 131.6 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family RRM_1 PF00076.22 EMD64454.1 - 1.7e-07 31.0 0.0 2.7e-07 30.3 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) LAMTOR PF15454.6 EMD64457.1 - 7.3e-13 48.9 0.6 1.5e-12 48.0 0.6 1.6 1 1 0 1 1 1 1 Late endosomal/lysosomal adaptor and MAPK and MTOR activator SUIM_assoc PF16619.5 EMD64457.1 - 0.031 14.3 0.7 0.056 13.5 0.7 1.4 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 SVIP PF15811.5 EMD64457.1 - 0.1 13.1 0.7 2.9 8.4 0.1 2.3 2 0 0 2 2 2 0 Small VCP/p97-interacting protein zf-UDP PF14569.6 EMD64458.1 - 0.037 14.1 0.7 0.037 14.1 0.7 2.1 2 0 0 2 2 2 0 Zinc-binding RING-finger TEBP_beta PF07404.11 EMD64458.1 - 0.64 9.3 8.0 1.1 8.6 8.0 1.3 1 0 0 1 1 1 0 Telomere-binding protein beta subunit (TEBP beta) ABC_tran PF00005.27 EMD64459.1 - 3e-32 112.0 0.0 6.4e-32 110.9 0.0 1.6 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 EMD64459.1 - 2.8e-27 96.1 5.0 2.8e-27 96.1 5.0 2.4 2 0 0 2 2 2 1 ABC transporter transmembrane region SMC_N PF02463.19 EMD64459.1 - 0.0001 21.8 0.0 0.00046 19.7 0.0 1.7 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 EMD64459.1 - 0.0079 16.1 0.0 0.018 15.0 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_10 PF12846.7 EMD64459.1 - 0.0084 15.1 0.0 0.014 14.3 0.0 1.3 1 0 0 1 1 1 1 AAA-like domain DUF4845 PF16137.5 EMD64459.1 - 0.024 15.5 0.0 0.073 13.9 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4845) AAA_16 PF13191.6 EMD64459.1 - 0.031 14.7 0.2 0.083 13.3 0.1 1.8 2 0 0 2 2 2 0 AAA ATPase domain AAA_22 PF13401.6 EMD64459.1 - 0.063 13.6 0.1 0.22 11.8 0.1 1.9 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EMD64459.1 - 0.83 9.4 2.8 1.5 8.7 0.5 2.7 3 0 0 3 3 3 0 P-loop containing region of AAA domain p450 PF00067.22 EMD64460.1 - 2.3e-77 260.7 0.0 2.9e-77 260.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF3762 PF12591.8 EMD64461.1 - 0.054 13.7 0.0 0.071 13.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3762) PBP PF01161.20 EMD64462.1 - 4.4e-17 62.6 0.0 5.3e-17 62.4 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein zf-MYND PF01753.18 EMD64466.1 - 1.9e-10 40.6 18.3 3.5e-10 39.8 18.3 1.4 1 0 0 1 1 1 1 MYND finger zf-Mss51 PF13824.6 EMD64466.1 - 0.043 13.9 3.6 0.071 13.2 3.6 1.4 1 0 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 PolC_DP2 PF03833.13 EMD64466.1 - 0.053 11.4 3.4 0.061 11.2 3.4 1.0 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 zf-C6H2 PF15801.5 EMD64466.1 - 0.059 13.7 9.5 0.059 13.7 9.5 2.0 2 0 0 2 2 2 0 zf-MYND-like zinc finger, mRNA-binding FAD_binding_4 PF01565.23 EMD64467.1 - 1.7e-16 60.2 0.0 2.8e-16 59.5 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EMD64467.1 - 0.092 12.9 0.0 0.22 11.6 0.0 1.6 1 0 0 1 1 1 0 Berberine and berberine like Cation_efflux PF01545.21 EMD64468.1 - 0.027 14.2 0.4 0.034 13.9 0.4 1.2 1 0 0 1 1 1 0 Cation efflux family Ion_trans_N PF08412.10 EMD64469.1 - 0.14 11.8 0.0 0.26 10.9 0.0 1.4 1 0 0 1 1 1 0 Ion transport protein N-terminal PhoD PF09423.10 EMD64471.1 - 2.6e-115 385.2 5.8 3.3e-115 384.9 5.8 1.1 1 0 0 1 1 1 1 PhoD-like phosphatase PhoD_N PF16655.5 EMD64471.1 - 6.5e-35 119.5 0.1 1.4e-34 118.5 0.1 1.6 1 0 0 1 1 1 1 PhoD-like phosphatase, N-terminal domain ADH_zinc_N_2 PF13602.6 EMD64471.1 - 2.8e-29 102.8 0.0 7.4e-29 101.5 0.0 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 EMD64471.1 - 1.6e-16 60.4 0.4 3.8e-16 59.3 0.1 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EMD64471.1 - 9.6e-06 25.4 3.2 4.4e-05 23.3 0.0 3.1 2 2 1 3 3 3 1 Alcohol dehydrogenase GroES-like domain Pur_ac_phosph_N PF16656.5 EMD64471.1 - 2.2e-05 24.9 2.1 6.7e-05 23.4 2.1 1.8 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain Metallophos PF00149.28 EMD64471.1 - 0.097 13.2 2.9 0.19 12.2 2.4 1.8 1 1 0 1 1 1 0 Calcineurin-like phosphoesterase ADH_zinc_N PF00107.26 EMD64472.1 - 3e-14 53.1 0.0 4.6e-14 52.5 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EMD64472.1 - 5.3e-08 32.7 0.1 1.3e-07 31.5 0.0 1.6 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 EMD64472.1 - 8.8e-07 30.0 0.0 1.6e-06 29.2 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Med7 PF05983.11 EMD64473.1 - 3.2e-57 193.7 1.3 4.1e-57 193.4 1.3 1.1 1 0 0 1 1 1 1 MED7 protein LTXXQ PF07813.12 EMD64473.1 - 0.076 13.7 2.5 1.7 9.4 1.5 2.5 2 0 0 2 2 2 0 LTXXQ motif family protein DUF2235 PF09994.9 EMD64474.1 - 2.1e-60 204.5 0.0 3e-60 204.0 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) Oxidored_FMN PF00724.20 EMD64475.1 - 1.1e-65 222.1 0.0 1.3e-65 221.9 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family KCH PF16944.5 EMD64477.1 - 2.5e-91 305.9 15.0 3.1e-91 305.6 15.0 1.1 1 0 0 1 1 1 1 Fungal potassium channel DUF2207 PF09972.9 EMD64477.1 - 2.4 6.8 4.8 6.6 5.4 0.1 2.4 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) DUF390 PF04094.14 EMD64479.1 - 2.7 6.2 6.8 3.6 5.8 6.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF390) TALPID3 PF15324.6 EMD64479.1 - 3.9 5.0 13.3 5.1 4.6 13.3 1.0 1 0 0 1 1 1 0 Hedgehog signalling target DUF3275 PF11679.8 EMD64479.1 - 9.6 6.1 7.9 17 5.3 7.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3275) HSP70 PF00012.20 EMD64480.1 - 1.6e-261 868.7 14.2 1.9e-261 868.5 14.2 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EMD64480.1 - 2.6e-20 72.5 0.8 4.3e-19 68.5 0.4 2.1 2 0 0 2 2 2 1 MreB/Mbl protein BcrAD_BadFG PF01869.20 EMD64480.1 - 0.01 15.3 0.3 0.95 8.9 0.1 2.6 2 0 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family FtsA PF14450.6 EMD64480.1 - 0.09 13.2 9.1 3.8 8.0 0.2 3.7 3 2 0 3 3 3 0 Cell division protein FtsA FGGY_C PF02782.16 EMD64480.1 - 0.097 12.4 0.0 0.59 9.8 0.0 2.2 2 0 0 2 2 2 0 FGGY family of carbohydrate kinases, C-terminal domain Borrelia_orfA PF02414.15 EMD64480.1 - 4.5 6.8 15.9 0.19 11.3 5.1 2.9 3 0 0 3 3 3 0 Borrelia ORF-A DUF1769 PF08588.10 EMD64481.1 - 1.1e-21 76.7 0.7 2.3e-21 75.7 0.7 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1769) ZapA PF05164.13 EMD64481.1 - 0.13 12.8 0.1 2.3 8.7 0.0 2.3 2 0 0 2 2 2 0 Cell division protein ZapA Lin-8 PF03353.15 EMD64481.1 - 2.1 7.8 5.4 3.2 7.3 5.4 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist FAM181 PF15238.6 EMD64482.1 - 0.13 12.1 0.5 0.21 11.4 0.5 1.3 1 0 0 1 1 1 0 FAM181 Gpi16 PF04113.14 EMD64483.1 - 1.8e-238 792.6 0.0 2.2e-238 792.3 0.0 1.0 1 0 0 1 1 1 1 Gpi16 subunit, GPI transamidase component LUC7 PF03194.15 EMD64484.1 - 9.1e-74 248.3 3.5 1.1e-73 248.0 3.5 1.0 1 0 0 1 1 1 1 LUC7 N_terminus MCPsignal PF00015.21 EMD64484.1 - 0.071 12.9 0.2 0.11 12.3 0.2 1.2 1 0 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain TelA PF05816.11 EMD64484.1 - 0.09 11.8 4.0 0.14 11.2 4.0 1.2 1 0 0 1 1 1 0 Toxic anion resistance protein (TelA) DASH_Duo1 PF08651.10 EMD64484.1 - 0.13 12.1 0.1 0.27 11.0 0.1 1.6 1 0 0 1 1 1 0 DASH complex subunit Duo1 Glutaredoxin2_C PF04399.13 EMD64484.1 - 0.16 11.8 0.1 0.36 10.7 0.1 1.5 1 0 0 1 1 1 0 Glutaredoxin 2, C terminal domain GRP PF07172.11 EMD64484.1 - 2.1 9.1 26.6 1.6 9.5 24.0 2.0 2 0 0 2 2 2 0 Glycine rich protein family DEAD PF00270.29 EMD64485.1 - 6e-42 143.4 0.0 1.1e-41 142.5 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EMD64485.1 - 2.4e-28 98.7 0.0 8.9e-28 96.9 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EMD64485.1 - 2.1e-05 24.6 0.0 2.1e-05 24.6 0.0 3.9 3 1 0 4 4 4 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EMD64485.1 - 0.63 10.3 2.2 1 9.6 0.0 2.5 3 0 0 3 3 3 0 AAA domain Presenilin PF01080.17 EMD64485.1 - 4.1 6.1 11.7 0.083 11.6 5.0 1.6 2 0 0 2 2 2 0 Presenilin FtsJ PF01728.19 EMD64486.1 - 8.1e-64 215.0 0.0 1.1e-63 214.6 0.0 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase Pkinase PF00069.25 EMD64487.1 - 2.3e-72 243.5 0.0 3.3e-72 243.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD64487.1 - 6.7e-45 153.4 0.0 1e-44 152.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 EMD64487.1 - 4.8e-22 78.1 0.3 1.3e-21 76.7 0.3 1.8 1 0 0 1 1 1 1 P21-Rho-binding domain Kinase-like PF14531.6 EMD64487.1 - 4.1e-08 32.9 0.1 9.6e-08 31.7 0.1 1.5 1 1 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EMD64487.1 - 2.3e-07 30.0 0.0 5e-07 28.8 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EMD64487.1 - 0.0077 16.2 0.1 0.057 13.3 0.0 2.3 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 EMD64487.1 - 0.0086 15.4 1.3 0.032 13.6 0.1 2.0 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EMD64487.1 - 0.031 13.2 1.0 0.065 12.2 1.0 1.5 1 1 0 1 1 1 0 Haspin like kinase domain DSHCT PF08148.12 EMD64487.1 - 0.098 12.3 0.0 0.18 11.4 0.0 1.4 1 0 0 1 1 1 0 DSHCT (NUC185) domain FTA2 PF13095.6 EMD64487.1 - 0.17 11.5 0.0 0.44 10.1 0.0 1.8 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 VHS PF00790.19 EMD64488.1 - 8.3e-36 122.9 0.4 1.5e-35 122.1 0.4 1.4 1 0 0 1 1 1 1 VHS domain SH3_1 PF00018.28 EMD64488.1 - 1.7e-16 59.5 0.0 4.1e-16 58.3 0.0 1.7 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EMD64488.1 - 1.3e-14 53.7 0.0 2.6e-14 52.8 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EMD64488.1 - 2.3e-14 52.8 0.0 4.3e-14 51.9 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain GAT PF03127.14 EMD64488.1 - 2.8e-11 43.6 0.0 7.1e-11 42.3 0.0 1.7 1 0 0 1 1 1 1 GAT domain UIM PF02809.20 EMD64488.1 - 0.024 14.6 4.3 0.057 13.4 4.3 1.7 1 0 0 1 1 1 0 Ubiquitin interaction motif PTA_PTB PF01515.19 EMD64488.1 - 0.083 12.2 0.0 0.15 11.4 0.0 1.3 1 1 0 1 1 1 0 Phosphate acetyl/butaryl transferase KH_1 PF00013.29 EMD64490.1 - 1.1e-90 297.4 24.8 1.6e-13 50.3 0.0 12.8 12 1 0 12 12 12 9 KH domain SLS PF14611.6 EMD64490.1 - 7.3e-17 61.9 6.7 0.095 12.5 0.0 8.2 5 3 2 8 8 8 6 Mitochondrial inner-membrane-bound regulator KH_2 PF07650.17 EMD64490.1 - 7.5e-11 41.7 15.7 0.086 12.7 0.1 7.6 7 0 0 7 7 7 4 KH domain KH_4 PF13083.6 EMD64490.1 - 0.00077 19.3 3.6 1.8 8.5 0.1 5.4 6 0 0 6 6 6 1 KH domain BMC PF00936.19 EMD64490.1 - 0.0015 18.5 1.2 2.9 7.9 0.1 3.2 3 0 0 3 3 3 2 BMC domain YbbR PF07949.12 EMD64490.1 - 0.019 15.3 1.8 2.2 8.7 0.0 4.5 4 0 0 4 4 4 0 YbbR-like protein KH_5 PF13184.6 EMD64490.1 - 2.2 8.4 9.1 8.6 6.5 0.1 5.1 6 0 0 6 6 6 0 NusA-like KH domain Strep_SA_rep PF06696.11 EMD64490.1 - 3.3 7.8 7.0 0.29 11.2 1.8 2.0 2 0 0 2 2 2 0 Streptococcal surface antigen repeat Nnf1 PF03980.14 EMD64490.1 - 9.4 6.7 8.6 19 5.6 0.1 4.3 4 0 0 4 4 4 0 Nnf1 PHY PF00360.20 EMD64491.1 - 2.6e-29 101.8 0.0 6e-29 100.6 0.0 1.6 1 0 0 1 1 1 1 Phytochrome region HATPase_c PF02518.26 EMD64491.1 - 6.4e-20 71.7 0.1 1.3e-19 70.7 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EMD64491.1 - 1.1e-16 61.0 0.0 4.7e-16 58.9 0.0 2.1 2 0 0 2 2 2 1 Response regulator receiver domain GAF PF01590.26 EMD64491.1 - 5e-14 53.1 0.0 2.5e-12 47.5 0.0 2.5 2 0 0 2 2 2 1 GAF domain HisKA PF00512.25 EMD64491.1 - 1.8e-12 47.1 1.0 7e-12 45.2 1.0 2.1 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain PAS_2 PF08446.11 EMD64491.1 - 1.5e-08 35.2 0.0 6.5e-08 33.2 0.0 2.1 2 0 0 2 2 2 1 PAS fold HATPase_c_2 PF13581.6 EMD64491.1 - 0.00074 19.5 0.1 0.0017 18.3 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain Flavoprotein PF02441.19 EMD64492.1 - 1.1e-15 57.8 0.0 2e-15 56.9 0.0 1.5 1 0 0 1 1 1 1 Flavoprotein Cyt-b5 PF00173.28 EMD64493.1 - 1.3e-22 79.8 0.3 1.7e-22 79.4 0.3 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain U62_UL91 PF17442.2 EMD64493.1 - 0.2 11.7 0.0 0.34 10.9 0.0 1.3 1 0 0 1 1 1 0 Functional domain of U62 and UL91 proteins NUC153 PF08159.12 EMD64494.1 - 2.3e-13 49.7 2.6 5.5e-13 48.5 2.6 1.7 1 0 0 1 1 1 1 NUC153 domain WD40 PF00400.32 EMD64494.1 - 0.014 16.2 0.0 23 6.1 0.0 3.7 3 0 0 3 3 3 0 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD64494.1 - 0.014 15.7 0.0 0.053 13.8 0.0 2.0 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Med13_C PF06333.12 EMD64495.1 - 2.7e-68 230.7 0.2 2.7e-68 230.7 0.2 5.2 4 2 1 5 5 5 1 Mediator complex subunit 13 C-terminal domain Med13_N PF11597.8 EMD64495.1 - 9e-61 205.9 7.4 9e-61 205.9 7.4 2.5 3 0 0 3 3 3 1 Mediator complex subunit 13 N-terminal MID_MedPIWI PF18296.1 EMD64495.1 - 3.3e-30 105.7 9.0 3.3e-29 102.4 0.0 4.3 4 1 0 4 4 4 1 MID domain of medPIWI AC_N PF16214.5 EMD64496.1 - 0.21 10.7 1.3 0.23 10.6 1.3 1.0 1 0 0 1 1 1 0 Adenylyl cyclase N-terminal extracellular and transmembrane region DHHC PF01529.20 EMD64497.1 - 7.6e-34 116.7 2.6 7.6e-34 116.7 2.6 2.8 2 2 0 2 2 2 1 DHHC palmitoyltransferase TatC PF00902.18 EMD64497.1 - 0.022 14.6 0.1 0.022 14.6 0.1 2.4 2 1 0 2 2 2 0 Sec-independent protein translocase protein (TatC) IGFBP PF00219.18 EMD64497.1 - 1.2 9.8 6.0 2 9.2 6.0 1.2 1 0 0 1 1 1 0 Insulin-like growth factor binding protein Myb_DNA-bind_2 PF08914.11 EMD64498.1 - 3e-24 85.0 0.7 7.4e-24 83.7 0.7 1.7 1 0 0 1 1 1 1 Rap1 Myb domain Rap1_C PF11626.8 EMD64498.1 - 3.2e-17 62.4 0.0 4.6e-16 58.7 0.0 2.7 2 0 0 2 2 2 1 TRF2-interacting telomeric protein/Rap1 - C terminal domain BRCT_2 PF16589.5 EMD64498.1 - 4.9e-11 42.9 0.1 5.6e-10 39.5 0.0 2.5 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain HMG_box PF00505.19 EMD64498.1 - 4.7e-06 26.9 0.1 3.4e-05 24.2 0.1 2.6 2 0 0 2 2 2 1 HMG (high mobility group) box Rap1-DNA-bind PF09197.10 EMD64498.1 - 0.00012 22.6 12.4 0.00015 22.3 0.1 3.7 3 2 1 4 4 4 2 Rap1, DNA-binding HMG_box_2 PF09011.10 EMD64498.1 - 0.0025 18.4 1.9 0.0058 17.2 0.1 2.6 2 0 0 2 2 2 1 HMG-box domain zf-Nse PF11789.8 EMD64499.1 - 2.2e-23 81.8 0.7 4.3e-23 80.9 0.7 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.6 EMD64499.1 - 5.3e-05 23.2 0.4 9.9e-05 22.3 0.4 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-MIZ PF02891.20 EMD64499.1 - 0.0035 17.1 0.4 0.0065 16.2 0.4 1.5 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-C3HC4_2 PF13923.6 EMD64499.1 - 0.012 15.4 0.2 0.025 14.4 0.0 1.6 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) ALMT PF11744.8 EMD64499.1 - 0.96 8.2 4.3 1.7 7.4 4.3 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter Mito_carr PF00153.27 EMD64500.1 - 1.9e-52 175.1 4.9 5.6e-18 64.7 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 EMD64500.1 - 0.024 13.8 1.9 0.084 12.0 1.2 2.4 1 1 0 1 1 1 0 Gammaproteobacterial serine protease F-actin_cap_A PF01267.17 EMD64501.1 - 5.4e-97 324.4 0.1 6.1e-97 324.2 0.1 1.0 1 0 0 1 1 1 1 F-actin capping protein alpha subunit CdiI_2 PF18593.1 EMD64501.1 - 0.076 13.7 0.1 0.46 11.2 0.0 2.2 3 0 0 3 3 3 0 CdiI immunity protein VHS PF00790.19 EMD64504.1 - 5.3e-25 87.9 0.0 1.1e-24 86.8 0.0 1.5 1 0 0 1 1 1 1 VHS domain GAT PF03127.14 EMD64504.1 - 7.9e-05 22.9 0.7 0.00018 21.8 0.7 1.6 1 0 0 1 1 1 1 GAT domain SR-25 PF10500.9 EMD64504.1 - 0.026 14.1 8.1 0.041 13.5 8.1 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Fungal_trans PF04082.18 EMD64505.1 - 4.1e-18 65.4 4.0 7e-18 64.6 4.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain VSP PF03302.13 EMD64507.1 - 0.0037 16.2 0.5 0.0043 16.0 0.5 1.1 1 0 0 1 1 1 1 Giardia variant-specific surface protein IlvB_leader PF08049.11 EMD64507.1 - 0.32 11.0 6.7 0.61 10.1 6.7 1.4 1 0 0 1 1 1 0 IlvB leader peptide Retrotrans_gag PF03732.17 EMD64508.1 - 1.8 8.9 8.6 4 7.8 2.0 3.9 2 0 0 2 2 2 0 Retrotransposon gag protein Ribosomal_L33 PF00471.20 EMD64509.1 - 1.6e-06 28.5 0.0 1.8e-06 28.2 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L33 Sugar_tr PF00083.24 EMD64510.1 - 1.1e-106 357.5 12.3 1.2e-106 357.3 12.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD64510.1 - 1.3e-22 80.3 23.1 1.8e-17 63.3 3.8 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily Peptidase_S10 PF00450.22 EMD64511.1 - 5.4e-102 342.3 0.3 6.3e-102 342.1 0.3 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase MetallophosN PF16371.5 EMD64511.1 - 0.0011 19.2 0.4 1.6 9.1 0.1 2.9 2 0 0 2 2 2 2 N terminal of Calcineurin-like phosphoesterase PNP_UDP_1 PF01048.20 EMD64514.1 - 8.1e-11 41.6 0.1 1.3e-10 40.9 0.1 1.3 1 0 0 1 1 1 1 Phosphorylase superfamily AAR2 PF05282.11 EMD64514.1 - 0.36 10.2 1.9 0.56 9.6 1.9 1.2 1 0 0 1 1 1 0 AAR2 protein RRN3 PF05327.11 EMD64514.1 - 8.6 4.8 7.0 12 4.2 7.0 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 WD40 PF00400.32 EMD64515.1 - 2e-51 170.8 4.2 2.5e-10 40.8 0.1 5.7 4 1 1 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD64515.1 - 2.4e-21 75.8 0.0 6.8e-05 23.1 0.0 4.5 1 1 3 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EMD64515.1 - 2.1e-11 43.4 0.8 0.02 13.9 0.0 4.4 1 1 2 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein HET PF06985.11 EMD64515.1 - 3.1e-11 43.8 5.6 5.1e-09 36.6 0.5 2.9 2 1 1 3 3 3 2 Heterokaryon incompatibility protein (HET) DUF1513 PF07433.11 EMD64515.1 - 1.3e-07 31.0 2.8 0.037 13.1 0.1 3.4 1 1 2 3 3 3 3 Protein of unknown function (DUF1513) Nup160 PF11715.8 EMD64515.1 - 1.5e-07 30.4 0.7 0.29 9.7 0.1 4.0 2 1 2 4 4 4 3 Nucleoporin Nup120/160 AAA_16 PF13191.6 EMD64515.1 - 4.4e-07 30.4 2.2 0.00015 22.2 0.1 4.0 3 1 0 3 3 2 1 AAA ATPase domain PD40 PF07676.12 EMD64515.1 - 6.3e-07 29.2 0.1 12 6.0 0.0 5.3 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat NACHT PF05729.12 EMD64515.1 - 4.7e-05 23.4 0.1 0.00012 22.1 0.1 1.6 1 0 0 1 1 1 1 NACHT domain Gmad1 PF10647.9 EMD64515.1 - 7.5e-05 22.6 6.4 0.27 11.0 1.4 3.9 1 1 3 4 4 4 3 Lipoprotein LpqB beta-propeller domain Proteasome_A_N PF10584.9 EMD64515.1 - 0.0008 19.0 0.0 74 3.2 0.0 4.9 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature AAA PF00004.29 EMD64515.1 - 0.004 17.6 0.2 0.016 15.6 0.2 2.0 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) IKI3 PF04762.12 EMD64515.1 - 0.0042 15.1 0.1 1.1 7.1 0.0 2.6 2 1 0 2 2 2 2 IKI3 family TruB_C PF09142.11 EMD64515.1 - 0.013 15.2 0.6 33 4.4 0.0 4.1 4 0 0 4 4 4 0 tRNA Pseudouridine synthase II, C terminal DUF4189 PF13827.6 EMD64515.1 - 0.024 15.1 1.0 6.6 7.3 0.1 3.9 1 1 3 4 4 4 0 Domain of unknown function (DUF4189) AAA_18 PF13238.6 EMD64515.1 - 0.024 15.2 0.0 0.21 12.1 0.0 2.5 2 0 0 2 2 2 0 AAA domain KAP_NTPase PF07693.14 EMD64515.1 - 0.029 13.6 0.0 0.051 12.8 0.0 1.4 1 0 0 1 1 1 0 KAP family P-loop domain AAA_22 PF13401.6 EMD64515.1 - 0.063 13.6 0.0 0.2 11.9 0.0 1.9 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 EMD64515.1 - 0.082 12.1 0.0 0.15 11.3 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain AAA_24 PF13479.6 EMD64515.1 - 0.098 12.4 0.0 0.21 11.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain WD40_like PF17005.5 EMD64515.1 - 0.2 11.0 0.0 17 4.6 0.0 2.7 2 1 0 2 2 2 0 WD40-like domain PhoH PF02562.16 EMD64515.1 - 0.23 10.9 0.0 8.8 5.7 0.0 2.3 2 0 0 2 2 2 0 PhoH-like protein TFIIIC_delta PF12657.7 EMD64515.1 - 2.7 7.9 4.4 72 3.2 0.1 4.2 3 1 1 5 5 5 0 Transcription factor IIIC subunit delta N-term ThrE PF06738.12 EMD64517.1 - 6e-66 222.3 1.6 6e-66 222.3 1.6 2.5 3 0 0 3 3 3 2 Putative threonine/serine exporter ThrE_2 PF12821.7 EMD64517.1 - 1.7e-06 28.2 1.4 1.7e-06 28.2 1.4 3.7 4 0 0 4 4 4 1 Threonine/Serine exporter, ThrE DUF2104 PF09877.9 EMD64517.1 - 0.16 12.2 1.9 0.78 10.0 0.0 2.7 3 0 0 3 3 3 0 Predicted membrane protein (DUF2104) FAD_binding_3 PF01494.19 EMD64518.1 - 2.5e-39 135.5 0.0 3.5e-39 135.0 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EMD64518.1 - 2.8e-06 26.8 0.0 4.1e-06 26.2 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EMD64518.1 - 9.2e-06 25.8 0.1 1.9e-05 24.8 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EMD64518.1 - 1e-05 25.4 0.7 0.01 15.4 0.2 2.5 3 0 0 3 3 3 2 FAD dependent oxidoreductase Thi4 PF01946.17 EMD64518.1 - 0.00013 21.3 0.1 0.00022 20.6 0.1 1.2 1 0 0 1 1 1 1 Thi4 family Pyr_redox PF00070.27 EMD64518.1 - 0.00039 20.9 0.0 0.016 15.7 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EMD64518.1 - 0.011 14.5 0.7 0.015 14.0 0.2 1.5 2 0 0 2 2 2 0 HI0933-like protein Lycopene_cycl PF05834.12 EMD64518.1 - 0.011 14.8 0.0 0.028 13.5 0.1 1.5 2 0 0 2 2 2 0 Lycopene cyclase protein FAD_binding_2 PF00890.24 EMD64518.1 - 0.013 14.6 0.0 0.021 13.9 0.0 1.4 1 0 0 1 1 1 0 FAD binding domain MADF_DNA_bdg PF10545.9 EMD64518.1 - 0.039 14.3 0.1 0.085 13.2 0.1 1.6 1 0 0 1 1 1 0 Alcohol dehydrogenase transcription factor Myb/SANT-like FAD_oxidored PF12831.7 EMD64518.1 - 0.042 13.2 0.0 0.067 12.5 0.0 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EMD64518.1 - 0.047 12.9 0.6 0.091 12.0 0.6 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EMD64518.1 - 0.067 13.2 0.1 0.14 12.1 0.1 1.6 1 0 0 1 1 1 0 FAD-NAD(P)-binding AlaDh_PNT_C PF01262.21 EMD64518.1 - 0.17 11.2 0.0 0.27 10.5 0.0 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain DUF346 PF03984.13 EMD64518.1 - 0.61 9.9 7.3 6 6.7 0.1 2.5 2 0 0 2 2 2 0 Repeat of unknown function (DUF346) adh_short_C2 PF13561.6 EMD64519.1 - 1e-36 126.7 1.0 3.2e-36 125.1 1.0 1.7 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EMD64519.1 - 4.2e-33 114.5 0.4 5.8e-33 114.0 0.4 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EMD64519.1 - 1.2e-05 25.3 0.1 2.7e-05 24.2 0.1 1.5 1 0 0 1 1 1 1 KR domain MFS_1 PF07690.16 EMD64520.1 - 5.8e-31 107.7 56.2 5.8e-31 107.7 56.2 2.5 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EMD64520.1 - 6.9e-07 28.5 12.9 6.9e-07 28.5 12.9 3.4 2 2 1 4 4 4 2 Sugar (and other) transporter Tad PF13400.6 EMD64520.1 - 4.5 7.7 0.0 4.5 7.7 0.0 4.2 4 0 0 4 4 4 0 Putative Flp pilus-assembly TadE/G-like OATP PF03137.20 EMD64520.1 - 5.6 5.1 18.7 0.079 11.2 5.6 3.2 2 2 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family DUF2306 PF10067.9 EMD64521.1 - 7e-16 58.8 10.5 7e-16 58.8 10.5 1.5 2 0 0 2 2 2 1 Predicted membrane protein (DUF2306) DUF420 PF04238.12 EMD64521.1 - 0.00037 20.8 1.0 0.00037 20.8 1.0 2.1 3 0 0 3 3 3 1 Protein of unknown function (DUF420) Aminotran_1_2 PF00155.21 EMD64522.1 - 2.8e-25 89.3 0.0 3.4e-25 89.0 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EMD64522.1 - 0.00012 20.8 0.0 0.0002 20.1 0.0 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Beta_elim_lyase PF01212.21 EMD64522.1 - 0.0022 17.3 0.0 0.0047 16.2 0.0 1.5 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_3 PF00202.21 EMD64522.1 - 0.0082 14.8 0.0 0.012 14.3 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class-III DegT_DnrJ_EryC1 PF01041.17 EMD64522.1 - 0.028 13.8 0.1 0.09 12.1 0.0 1.9 2 0 0 2 2 2 0 DegT/DnrJ/EryC1/StrS aminotransferase family PS-DH PF14765.6 EMD64523.1 - 3.1e-68 230.2 0.0 5.8e-68 229.3 0.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 EMD64523.1 - 1.3e-59 202.3 0.2 2.6e-59 201.3 0.2 1.5 1 0 0 1 1 1 1 Acyl transferase domain KR PF08659.10 EMD64523.1 - 1.9e-59 200.6 0.0 1.3e-58 197.9 0.0 2.4 2 0 0 2 2 2 1 KR domain ketoacyl-synt PF00109.26 EMD64523.1 - 8.9e-57 192.5 0.0 1.9e-56 191.5 0.0 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 EMD64523.1 - 6.1e-33 113.3 0.3 1.9e-32 111.8 0.3 1.9 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 EMD64523.1 - 4.8e-23 81.8 0.0 2.4e-22 79.5 0.0 2.3 2 0 0 2 2 1 1 Ketoacyl-synthetase C-terminal extension Methyltransf_12 PF08242.12 EMD64523.1 - 1.8e-14 54.2 0.0 7.6e-14 52.3 0.0 2.1 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EMD64523.1 - 1.4e-12 47.7 0.0 3.6e-12 46.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain ADH_zinc_N PF00107.26 EMD64523.1 - 1.2e-11 44.7 0.8 4.1e-10 39.7 0.2 3.6 4 0 0 4 4 3 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EMD64523.1 - 3.7e-10 41.0 0.0 4.8e-09 37.4 0.1 2.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Methyltransf_31 PF13847.6 EMD64523.1 - 1.8e-08 34.3 0.0 5.4e-08 32.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain adh_short_C2 PF13561.6 EMD64523.1 - 2.7e-08 33.7 0.0 1.5e-07 31.2 0.0 2.3 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EMD64523.1 - 6.8e-08 32.2 0.0 1.9e-07 30.7 0.0 1.8 1 0 0 1 1 1 1 short chain dehydrogenase PP-binding PF00550.25 EMD64523.1 - 6.9e-08 32.7 0.1 9.8e-07 29.0 0.1 2.4 2 0 0 2 2 2 1 Phosphopantetheine attachment site Methyltransf_25 PF13649.6 EMD64523.1 - 2.8e-07 31.2 0.0 1e-06 29.3 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMD64523.1 - 9.4e-06 26.2 0.0 2.9e-05 24.6 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain NAD_binding_10 PF13460.6 EMD64523.1 - 0.00025 21.0 0.1 0.04 13.8 0.0 2.6 2 0 0 2 2 2 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 EMD64523.1 - 0.011 15.1 0.0 0.019 14.4 0.0 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Thiolase_N PF00108.23 EMD64523.1 - 0.014 14.7 0.2 0.03 13.7 0.2 1.4 1 0 0 1 1 1 0 Thiolase, N-terminal domain NmrA PF05368.13 EMD64523.1 - 0.015 14.9 0.2 0.18 11.3 0.0 2.5 2 0 0 2 2 2 0 NmrA-like family Epimerase PF01370.21 EMD64523.1 - 0.028 13.9 0.0 0.059 12.8 0.0 1.5 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family ADH_N PF08240.12 EMD64523.1 - 0.076 12.9 0.0 0.18 11.7 0.0 1.6 1 0 0 1 1 1 0 Alcohol dehydrogenase GroES-like domain Ubie_methyltran PF01209.18 EMD64523.1 - 0.12 11.7 0.0 0.22 10.8 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Helo_like_N PF17111.5 EMD64524.1 - 2.2e-29 102.3 3.8 2.2e-29 102.3 3.8 2.1 1 1 0 2 2 2 1 Fungal N-terminal domain of STAND proteins SesA PF17107.5 EMD64524.1 - 6.2e-06 26.4 0.2 6.2e-06 26.4 0.2 2.2 2 1 0 2 2 2 1 N-terminal domain on NACHT_NTPase and P-loop NTPases AI-2E_transport PF01594.16 EMD64524.1 - 0.041 13.0 3.2 0.036 13.2 1.3 1.8 1 1 0 1 1 1 0 AI-2E family transporter TMPIT PF07851.13 EMD64524.1 - 0.11 11.7 7.1 0.072 12.3 5.4 1.5 2 0 0 2 2 2 0 TMPIT-like protein Trimer_CC PF08954.11 EMD64524.1 - 0.17 11.4 1.7 30 4.3 0.0 3.6 3 0 0 3 3 3 0 Trimerisation motif Ank_4 PF13637.6 EMD64525.1 - 3.3e-29 100.9 2.5 8.9e-10 38.9 0.0 3.6 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 EMD64525.1 - 1.6e-21 76.6 0.1 2.4e-11 44.1 0.1 2.5 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 EMD64525.1 - 3.1e-21 74.8 4.1 8.7e-07 29.1 0.0 5.0 5 0 0 5 5 5 3 Ankyrin repeat Ank_3 PF13606.6 EMD64525.1 - 4e-19 66.7 2.2 2.1e-05 24.5 0.0 5.0 5 0 0 5 5 5 3 Ankyrin repeat Ank_5 PF13857.6 EMD64525.1 - 2.6e-18 65.8 0.8 1.3e-09 38.1 0.1 3.1 2 1 0 2 2 2 2 Ankyrin repeats (many copies) NACHT PF05729.12 EMD64525.1 - 7.7e-10 38.9 0.0 2.4e-09 37.3 0.0 1.9 2 0 0 2 2 2 1 NACHT domain AAA_22 PF13401.6 EMD64525.1 - 0.017 15.4 0.0 0.056 13.7 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EMD64525.1 - 0.06 13.7 0.0 0.21 12.0 0.0 1.9 1 0 0 1 1 1 0 AAA ATPase domain Ank_2 PF12796.7 EMD64526.1 - 2.6e-16 60.0 0.0 3.7e-16 59.5 0.0 1.3 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EMD64526.1 - 2.7e-14 51.8 0.0 0.0021 18.4 0.0 3.1 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.6 EMD64526.1 - 6.5e-12 45.7 0.0 1.4e-07 31.9 0.0 2.1 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 EMD64526.1 - 8.4e-11 41.9 0.0 6.6e-05 23.1 0.0 2.9 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 EMD64526.1 - 9.2e-11 41.7 0.0 0.0037 17.7 0.0 3.1 3 0 0 3 3 3 3 Ankyrin repeat VWA_3_C PF18571.1 EMD64526.1 - 0.0027 17.5 0.3 18 5.3 0.0 3.4 3 1 0 3 3 3 2 von Willebrand factor type A C-terminal domain DUF3425 PF11905.8 EMD64527.1 - 7.9e-10 38.8 0.3 1.6e-09 37.8 0.3 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) NmrA PF05368.13 EMD64528.1 - 8.3e-29 100.8 0.0 1.1e-27 97.2 0.0 2.0 1 1 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EMD64528.1 - 7.1e-09 35.8 0.0 1.6e-08 34.7 0.0 1.6 2 0 0 2 2 2 1 NAD(P)H-binding Epimerase PF01370.21 EMD64528.1 - 0.00011 21.8 0.0 0.00016 21.2 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family TrkA_N PF02254.18 EMD64528.1 - 0.011 15.9 0.0 0.029 14.6 0.0 1.7 2 0 0 2 2 2 0 TrkA-N domain AflR PF08493.10 EMD64530.1 - 4.8e-08 32.8 18.8 1e-06 28.4 18.8 2.3 1 1 0 1 1 1 1 Aflatoxin regulatory protein Zn_clus PF00172.18 EMD64530.1 - 4.9e-08 33.0 12.2 1.1e-07 31.8 12.2 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain COX15-CtaA PF02628.15 EMD64531.1 - 2.8e-109 365.1 10.8 3.4e-109 364.8 10.8 1.1 1 0 0 1 1 1 1 Cytochrome oxidase assembly protein BTB PF00651.31 EMD64532.1 - 0.001 19.2 0.0 0.0026 18.0 0.0 1.6 2 0 0 2 2 2 1 BTB/POZ domain Chromate_transp PF02417.15 EMD64532.1 - 0.043 13.9 0.0 0.078 13.1 0.0 1.3 1 0 0 1 1 1 0 Chromate transporter PNP_UDP_1 PF01048.20 EMD64535.1 - 4.9e-39 134.0 0.0 6e-39 133.7 0.0 1.1 1 0 0 1 1 1 1 Phosphorylase superfamily Amidase PF01425.21 EMD64536.1 - 2e-71 241.3 0.8 5.6e-71 239.8 0.8 1.6 1 1 0 1 1 1 1 Amidase LT-IIB PF06453.11 EMD64536.1 - 0.23 11.4 1.1 1.9 8.4 0.4 2.4 2 0 0 2 2 2 0 Type II heat-labile enterotoxin , B subunit (LT-IIB) SelR PF01641.18 EMD64537.1 - 1.7e-47 160.4 0.0 2.7e-47 159.8 0.0 1.3 1 0 0 1 1 1 1 SelR domain zf-MYND PF01753.18 EMD64538.1 - 0.0041 17.2 2.0 0.0061 16.6 2.0 1.3 1 0 0 1 1 1 1 MYND finger MFS_1 PF07690.16 EMD64539.1 - 2.3e-22 79.4 22.0 2.3e-22 79.4 22.0 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily FMO-like PF00743.19 EMD64540.1 - 2e-14 52.9 0.0 3.9e-11 42.1 0.0 2.7 2 1 0 2 2 2 2 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.6 EMD64540.1 - 8e-11 42.0 0.0 6.7e-10 39.1 0.0 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EMD64540.1 - 9.1e-09 35.0 0.0 2.6e-05 23.6 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EMD64540.1 - 0.00029 20.1 0.1 0.088 11.9 0.0 3.1 3 1 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.24 EMD64540.1 - 0.00063 19.4 0.5 1.5 8.3 0.0 3.1 2 1 1 3 3 3 2 FAD dependent oxidoreductase Pyr_redox PF00070.27 EMD64540.1 - 0.041 14.4 0.1 0.6 10.7 0.0 2.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EMD64540.1 - 0.052 12.8 0.0 0.11 11.8 0.0 1.4 1 0 0 1 1 1 0 Thi4 family Shikimate_DH PF01488.20 EMD64540.1 - 0.14 12.2 0.0 0.93 9.5 0.0 2.1 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Amino_oxidase PF01593.24 EMD64540.1 - 0.14 11.4 0.0 1.3 8.2 0.0 2.1 1 1 0 1 1 1 0 Flavin containing amine oxidoreductase Asparaginase_2 PF01112.18 EMD64541.1 - 1.7e-23 83.1 3.9 2.5e-17 62.9 0.5 2.2 2 0 0 2 2 2 2 Asparaginase Cation_ATPase_C PF00689.21 EMD64542.1 - 1.6 8.4 18.9 3.5 7.3 0.3 2.8 1 1 3 4 4 4 0 Cation transporting ATPase, C-terminus Ysc84 PF04366.12 EMD64543.1 - 2.7e-42 143.6 0.0 4.9e-42 142.7 0.0 1.4 1 0 0 1 1 1 1 Las17-binding protein actin regulator SH3_1 PF00018.28 EMD64543.1 - 2.9e-13 49.2 0.3 7.4e-13 47.9 0.1 1.8 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.17 EMD64543.1 - 8.5e-12 44.6 0.0 2.4e-11 43.1 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 EMD64543.1 - 6e-10 38.8 0.0 1.2e-09 37.9 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain DUF4741 PF15897.5 EMD64543.1 - 0.032 14.0 0.1 0.063 13.1 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4741) adh_short PF00106.25 EMD64545.1 - 1.9e-28 99.2 0.5 4.6e-28 98.0 0.5 1.6 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD64545.1 - 6e-19 68.5 0.0 1.7e-18 67.1 0.0 1.6 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD64545.1 - 0.011 15.7 0.5 2.5 8.0 0.6 2.7 2 1 0 2 2 2 0 KR domain Epimerase PF01370.21 EMD64545.1 - 0.062 12.7 0.2 0.15 11.5 0.2 1.7 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Abhydrolase_3 PF07859.13 EMD64546.1 - 1.2e-41 142.9 0.0 5.9e-32 111.2 0.0 2.5 2 0 0 2 2 2 2 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 EMD64546.1 - 2.4e-16 59.6 0.1 6.2e-16 58.2 0.0 1.6 2 0 0 2 2 2 1 Steryl acetyl hydrolase COesterase PF00135.28 EMD64546.1 - 0.021 13.7 0.1 0.5 9.2 0.0 2.1 2 0 0 2 2 2 0 Carboxylesterase family Hydrolase_4 PF12146.8 EMD64546.1 - 0.03 13.6 0.0 0.061 12.6 0.0 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 DUF572 PF04502.13 EMD64547.1 - 8.3e-72 242.6 0.1 9.5e-72 242.4 0.1 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF572) GTP_EFTU PF00009.27 EMD64548.1 - 4.2e-42 143.9 0.0 6.7e-42 143.2 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EMD64548.1 - 4.3e-29 101.1 0.1 9.4e-29 100.0 0.1 1.6 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EMD64548.1 - 1.7e-05 25.1 0.1 5.3e-05 23.5 0.1 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EMD64548.1 - 0.00037 20.6 1.0 0.0047 17.0 0.1 2.9 2 1 0 2 2 2 1 50S ribosome-binding GTPase Ran-binding PF05508.11 EMD64549.1 - 1.4e-124 415.2 0.0 1.8e-124 414.8 0.0 1.1 1 0 0 1 1 1 1 RanGTP-binding protein Med15 PF09606.10 EMD64549.1 - 6.8 5.2 11.5 3.1 6.4 3.4 2.1 2 0 0 2 2 2 0 ARC105 or Med15 subunit of Mediator complex non-fungal BSD PF03909.17 EMD64550.1 - 5.5e-18 64.7 0.6 1.2e-17 63.7 0.6 1.6 1 0 0 1 1 1 1 BSD domain BSP_II PF05432.11 EMD64550.1 - 7.4e-05 22.6 15.4 7.4e-05 22.6 15.4 2.6 2 1 0 2 2 2 1 Bone sialoprotein II (BSP-II) ApoA-II PF04711.13 EMD64550.1 - 0.05 13.8 0.1 0.16 12.1 0.0 1.9 2 0 0 2 2 2 0 Apolipoprotein A-II (ApoA-II) DNA_pol_phi PF04931.13 EMD64550.1 - 7.2 4.6 37.6 0.21 9.7 28.0 2.2 2 0 0 2 2 2 0 DNA polymerase phi WGG PF10273.9 EMD64551.1 - 1.2e-27 96.4 0.8 2.1e-27 95.6 0.8 1.4 1 0 0 1 1 1 1 Pre-rRNA-processing protein TSR2 KfrA_N PF11740.8 EMD64551.1 - 0.0075 16.9 0.1 0.012 16.3 0.1 1.4 1 0 0 1 1 1 1 Plasmid replication region DNA-binding N-term Tautomerase_2 PF14552.6 EMD64551.1 - 0.12 12.5 0.0 0.19 11.9 0.0 1.3 1 0 0 1 1 1 0 Tautomerase enzyme RRP7 PF12923.7 EMD64551.1 - 0.13 12.4 0.1 0.13 12.4 0.1 2.0 1 1 1 2 2 2 0 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain SURF2 PF05477.11 EMD64551.1 - 0.38 10.4 2.9 0.52 10.0 2.9 1.2 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) PH PF00169.29 EMD64553.1 - 0.15 12.6 0.0 0.27 11.8 0.0 1.4 1 0 0 1 1 1 0 PH domain Pkinase PF00069.25 EMD64555.1 - 2.9e-66 223.5 0.0 4.4e-66 222.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD64555.1 - 1.1e-31 110.0 0.0 1.7e-31 109.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Glyco_hydro_18 PF00704.28 EMD64555.1 - 2.9e-12 47.0 0.0 1.2e-11 45.0 0.0 2.0 2 0 0 2 2 2 1 Glycosyl hydrolases family 18 UBA PF00627.31 EMD64555.1 - 3.2e-08 33.3 0.2 1.2e-07 31.5 0.1 2.0 2 0 0 2 2 2 1 UBA/TS-N domain Haspin_kinase PF12330.8 EMD64555.1 - 0.0026 16.8 0.1 0.045 12.7 0.0 2.0 2 0 0 2 2 2 1 Haspin like kinase domain Kinase-like PF14531.6 EMD64555.1 - 0.03 13.7 0.1 0.067 12.5 0.0 1.5 2 0 0 2 2 2 0 Kinase-like APH PF01636.23 EMD64555.1 - 0.094 12.6 0.0 0.23 11.3 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family RuvA_C PF07499.13 EMD64555.1 - 0.17 12.4 0.1 0.5 10.9 0.1 1.7 1 0 0 1 1 1 0 RuvA, C-terminal domain Arrestin_C PF02752.22 EMD64556.1 - 1.8e-13 51.1 0.3 2.2e-12 47.6 0.0 2.3 2 1 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 EMD64556.1 - 1.9e-12 47.4 0.0 1.3e-11 44.8 0.0 2.0 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain CTD PF12815.7 EMD64556.1 - 0.57 10.8 6.9 0.99 10.0 3.9 2.6 2 0 0 2 2 2 0 Spt5 C-terminal nonapeptide repeat binding Spt4 WD40 PF00400.32 EMD64558.1 - 1.6e-12 47.7 11.1 8.2e-05 23.3 0.2 6.0 5 1 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD64558.1 - 7.1e-11 42.3 0.1 0.00045 20.5 0.0 3.8 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EMD64558.1 - 0.0095 15.8 0.1 0.092 12.6 0.0 2.1 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A Utp8 PF10395.9 EMD64558.1 - 0.024 13.2 0.0 0.036 12.6 0.0 1.2 1 0 0 1 1 1 0 Utp8 family Cytochrom_D1 PF02239.16 EMD64558.1 - 0.025 13.1 0.0 0.13 10.7 0.0 1.7 1 1 1 2 2 2 0 Cytochrome D1 heme domain IKI3 PF04762.12 EMD64558.1 - 0.03 12.3 0.0 0.32 8.9 0.0 1.9 1 1 1 2 2 2 0 IKI3 family PD40 PF07676.12 EMD64558.1 - 0.065 13.2 0.0 22 5.1 0.0 2.9 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat EF_assoc_2 PF08356.12 EMD64559.1 - 7.6e-34 115.6 0.0 1.6e-33 114.5 0.0 1.6 1 0 0 1 1 1 1 EF hand associated EF_assoc_1 PF08355.12 EMD64559.1 - 2.5e-29 100.7 0.3 4.5e-29 99.8 0.3 1.5 1 0 0 1 1 1 1 EF hand associated Ras PF00071.22 EMD64559.1 - 8e-26 90.6 0.0 5.8e-15 55.3 0.0 2.2 2 0 0 2 2 2 2 Ras family Roc PF08477.13 EMD64559.1 - 5.6e-15 55.6 0.0 9.8e-09 35.5 0.0 2.4 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 EMD64559.1 - 5.8e-09 36.0 0.0 4.4e-05 23.5 0.0 2.9 3 1 0 3 3 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EMD64559.1 - 6.6e-07 29.4 0.0 0.19 11.6 0.0 3.3 3 0 0 3 3 3 2 RsgA GTPase EF-hand_6 PF13405.6 EMD64559.1 - 1.8e-05 24.3 2.3 0.022 14.6 0.1 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 EMD64559.1 - 6.6e-05 22.2 1.5 0.18 11.4 0.8 2.7 2 0 0 2 2 2 2 EF hand AAA_16 PF13191.6 EMD64559.1 - 0.0001 22.8 0.0 0.072 13.5 0.0 2.7 2 0 0 2 2 2 1 AAA ATPase domain AAA_29 PF13555.6 EMD64559.1 - 0.00023 20.8 0.1 0.18 11.6 0.0 2.4 2 0 0 2 2 2 1 P-loop containing region of AAA domain ABC_tran PF00005.27 EMD64559.1 - 0.00042 20.8 0.0 0.2 12.1 0.0 2.4 2 0 0 2 2 2 1 ABC transporter AAA_22 PF13401.6 EMD64559.1 - 0.00053 20.3 0.0 0.33 11.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 EMD64559.1 - 0.00092 19.6 0.1 0.52 10.7 0.0 2.7 3 0 0 3 3 2 1 RNA helicase Dynamin_N PF00350.23 EMD64559.1 - 0.0012 18.9 0.0 0.57 10.2 0.0 2.6 2 0 0 2 2 2 1 Dynamin family EF-hand_7 PF13499.6 EMD64559.1 - 0.0017 18.8 0.4 0.19 12.2 0.1 2.6 2 0 0 2 2 2 1 EF-hand domain pair AAA_24 PF13479.6 EMD64559.1 - 0.0027 17.4 0.0 0.78 9.4 0.0 2.4 2 0 0 2 2 2 1 AAA domain EF-hand_5 PF13202.6 EMD64559.1 - 0.006 16.0 3.5 0.17 11.5 2.2 2.7 2 0 0 2 2 2 1 EF hand AAA_7 PF12775.7 EMD64559.1 - 0.0091 15.5 0.0 1.7 8.1 0.0 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region DUF815 PF05673.13 EMD64559.1 - 0.01 15.0 0.0 3.2 6.8 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Arf PF00025.21 EMD64559.1 - 0.011 15.2 0.0 9.3 5.7 0.1 3.2 2 1 0 2 2 2 0 ADP-ribosylation factor family Septin PF00735.18 EMD64559.1 - 0.018 14.4 0.0 1.6 8.0 0.0 2.2 2 0 0 2 2 2 0 Septin AAA_18 PF13238.6 EMD64559.1 - 0.024 15.2 0.5 0.89 10.1 0.0 3.1 4 0 0 4 4 2 0 AAA domain EF-hand_8 PF13833.6 EMD64559.1 - 0.025 14.4 2.5 0.79 9.6 1.3 2.4 2 0 0 2 2 2 0 EF-hand domain pair VirE PF05272.11 EMD64559.1 - 0.036 13.8 0.0 1.9 8.2 0.0 2.3 2 0 0 2 2 2 0 Virulence-associated protein E NACHT PF05729.12 EMD64559.1 - 0.057 13.3 0.0 8 6.3 0.0 2.7 2 0 0 2 2 2 0 NACHT domain Ploopntkinase3 PF18751.1 EMD64559.1 - 0.066 13.1 0.0 2.6 7.9 0.0 2.3 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 G-alpha PF00503.20 EMD64559.1 - 0.072 12.2 0.0 0.82 8.8 0.0 2.2 2 0 0 2 2 2 0 G-protein alpha subunit SPARC_Ca_bdg PF10591.9 EMD64559.1 - 0.083 13.2 0.1 30 5.0 0.1 2.8 2 1 0 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region AIG1 PF04548.16 EMD64559.1 - 0.13 11.6 0.2 0.78 9.0 0.0 2.2 2 0 0 2 2 2 0 AIG1 family EF-hand_10 PF14788.6 EMD64559.1 - 0.13 12.1 0.5 1.2 9.0 0.1 2.3 2 0 0 2 2 2 0 EF hand AAA_28 PF13521.6 EMD64559.1 - 0.17 12.1 0.0 3.2 8.0 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 EMD64559.1 - 0.19 12.2 0.3 11 6.5 0.1 2.9 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) ATP_bind_1 PF03029.17 EMD64559.1 - 0.21 11.3 0.6 24 4.6 0.0 2.9 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein Zds_C PF08632.10 EMD64560.1 - 8.9e-29 99.0 1.2 1.6e-28 98.2 1.2 1.4 1 0 0 1 1 1 1 Activator of mitotic machinery Cdc14 phosphatase activation C-term TFIIA PF03153.13 EMD64560.1 - 0.87 9.5 90.2 0.32 11.0 53.8 3.0 3 0 0 3 3 3 0 Transcription factor IIA, alpha/beta subunit Cupin_5 PF06172.11 EMD64561.1 - 6.1e-47 159.3 0.0 7.7e-47 159.0 0.0 1.1 1 0 0 1 1 1 1 Cupin superfamily (DUF985) zf-UBP PF02148.19 EMD64562.1 - 0.069 13.5 0.5 29 5.1 0.1 3.3 3 0 0 3 3 3 0 Zn-finger in ubiquitin-hydrolases and other protein Fe-ADH PF00465.19 EMD64563.1 - 3e-104 348.7 0.0 3.7e-104 348.4 0.0 1.0 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 EMD64563.1 - 4.2e-15 56.1 0.0 3.6e-11 43.2 0.0 2.3 2 0 0 2 2 2 2 Iron-containing alcohol dehydrogenase Dehydratase_MU PF02288.15 EMD64563.1 - 0.15 12.0 0.1 0.38 10.7 0.1 1.6 1 0 0 1 1 1 0 Dehydratase medium subunit SET PF00856.28 EMD64564.1 - 2.3e-13 50.9 0.0 3.8e-12 46.9 0.0 2.6 1 1 0 1 1 1 1 SET domain Cu-oxidase_3 PF07732.15 EMD64565.1 - 1.8e-42 144.1 8.9 3.5e-39 133.5 0.9 3.3 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase_2 PF07731.14 EMD64565.1 - 5.8e-34 116.8 7.9 2.2e-33 114.9 1.0 3.0 2 1 0 2 2 2 2 Multicopper oxidase Cu-oxidase PF00394.22 EMD64565.1 - 1.7e-26 93.2 0.0 3.7e-23 82.4 0.0 3.2 3 0 0 3 3 3 2 Multicopper oxidase RTA1 PF04479.13 EMD64566.1 - 2.1e-75 252.9 8.6 2.6e-75 252.6 8.6 1.1 1 0 0 1 1 1 1 RTA1 like protein TraQ PF09679.10 EMD64566.1 - 0.083 12.8 0.3 0.2 11.6 0.3 1.7 1 0 0 1 1 1 0 Type-F conjugative transfer system pilin chaperone (TraQ) 7TM_GPCR_Srh PF10318.9 EMD64566.1 - 0.45 9.5 9.6 0.2 10.7 1.1 2.7 2 2 1 3 3 3 0 Serpentine type 7TM GPCR chemoreceptor Srh DUF3425 PF11905.8 EMD64568.1 - 4e-12 46.2 1.5 7.6e-12 45.3 1.5 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) Zn_clus PF00172.18 EMD64568.1 - 1.4e-08 34.7 7.9 2.5e-08 33.9 7.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DnaJ PF00226.31 EMD64569.1 - 1.4e-09 37.9 0.1 1.6e-09 37.8 0.1 1.0 1 0 0 1 1 1 1 DnaJ domain Glyoxalase_3 PF13468.6 EMD64570.1 - 5.5e-06 26.6 0.0 6.9e-06 26.3 0.0 1.3 1 1 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_4 PF13669.6 EMD64570.1 - 0.0027 18.0 0.0 0.029 14.6 0.0 2.1 2 0 0 2 2 2 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily zf-C2H2_4 PF13894.6 EMD64571.1 - 0.033 15.0 2.9 2.3 9.3 0.2 3.0 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2 PF00096.26 EMD64571.1 - 0.035 14.6 0.4 0.035 14.6 0.4 3.0 3 1 0 3 3 3 0 Zinc finger, C2H2 type HNH_5 PF14279.6 EMD64571.1 - 0.1 12.5 2.3 0.76 9.7 1.4 2.3 2 0 0 2 2 2 0 HNH endonuclease zf-C2H2_2 PF12756.7 EMD64571.1 - 1.5 9.2 5.7 9.6 6.6 3.9 2.2 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf_C2HC_14 PF18574.1 EMD64571.1 - 1.8 8.5 4.5 0.5 10.2 0.2 2.1 2 0 0 2 2 2 0 C2HC Zing finger domain Zn_Tnp_IS1595 PF12760.7 EMD64571.1 - 5.2 7.1 8.8 1.2 9.1 4.3 2.4 2 1 0 2 2 2 0 Transposase zinc-ribbon domain Thiolase_N PF00108.23 EMD64572.1 - 1.5e-12 47.5 0.1 2.2e-09 37.1 0.0 3.1 2 1 0 2 2 2 2 Thiolase, N-terminal domain Thiolase_C PF02803.18 EMD64572.1 - 1.1e-11 44.4 1.2 7.9e-11 41.7 0.4 2.6 2 1 1 3 3 3 1 Thiolase, C-terminal domain ACP_syn_III PF08545.10 EMD64572.1 - 4.2e-07 29.7 0.0 6.6e-05 22.7 0.1 2.5 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III ketoacyl-synt PF00109.26 EMD64572.1 - 5e-06 26.3 0.4 3e-05 23.7 0.2 2.3 2 1 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 EMD64572.1 - 0.01 15.8 0.1 0.22 11.5 0.0 2.7 2 0 0 2 2 2 0 Beta-ketoacyl synthase, C-terminal domain SpoVAD PF07451.11 EMD64572.1 - 0.027 13.2 0.1 0.25 10.0 0.0 2.0 2 0 0 2 2 2 0 Stage V sporulation protein AD (SpoVAD) DUF3208 PF11482.8 EMD64572.1 - 0.21 11.9 0.0 4 7.8 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3208) CDH-cyt PF16010.5 EMD64573.1 - 1e-52 178.5 0.2 1.8e-52 177.7 0.2 1.4 1 0 0 1 1 1 1 Cytochrome domain of cellobiose dehydrogenase GMC_oxred_N PF00732.19 EMD64573.1 - 5.3e-33 114.7 0.0 7.4e-33 114.2 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EMD64573.1 - 1.8e-17 64.2 0.5 3.7e-17 63.2 0.5 1.5 1 0 0 1 1 1 1 GMC oxidoreductase CBM_1 PF00734.18 EMD64573.1 - 4.9e-13 48.8 6.8 1.2e-12 47.6 6.8 1.7 1 0 0 1 1 1 1 Fungal cellulose binding domain FAD_binding_2 PF00890.24 EMD64573.1 - 2.5e-06 26.9 3.9 0.0011 18.1 1.7 2.3 2 0 0 2 2 2 2 FAD binding domain FAD_oxidored PF12831.7 EMD64573.1 - 0.00083 18.8 5.3 0.0027 17.1 2.6 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase HI0933_like PF03486.14 EMD64573.1 - 0.00084 18.2 2.1 0.00096 18.0 1.0 1.6 2 0 0 2 2 2 1 HI0933-like protein DAO PF01266.24 EMD64573.1 - 0.0048 16.5 5.0 0.66 9.5 0.8 2.6 2 1 0 2 2 2 2 FAD dependent oxidoreductase GIDA PF01134.22 EMD64573.1 - 0.014 14.5 0.1 0.024 13.7 0.1 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A Pyr_redox_2 PF07992.14 EMD64573.1 - 0.017 14.4 4.5 0.025 13.8 0.2 2.5 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EMD64573.1 - 0.035 13.2 1.0 0.097 11.7 0.1 2.2 3 0 0 3 3 3 0 Lycopene cyclase protein Pyr_redox PF00070.27 EMD64573.1 - 0.39 11.3 2.1 7.6 7.2 0.4 2.9 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EMD64573.1 - 2 7.6 3.9 2.6 7.2 1.8 2.1 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EMD64573.1 - 4.5 7.6 7.4 0.31 11.3 1.1 2.3 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain ParA PF10609.9 EMD64574.1 - 2e-92 309.1 0.0 2.3e-92 308.9 0.0 1.0 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 EMD64574.1 - 2.3e-13 50.3 0.0 9.4e-13 48.3 0.0 1.8 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 EMD64574.1 - 2.5e-11 43.8 0.2 4.4e-09 36.5 0.2 2.5 2 1 0 2 2 2 1 AAA domain MipZ PF09140.11 EMD64574.1 - 5.1e-06 26.0 0.0 7.6e-06 25.4 0.0 1.4 1 1 0 1 1 1 1 ATPase MipZ ArsA_ATPase PF02374.15 EMD64574.1 - 0.00013 21.2 0.2 0.0049 16.1 0.1 2.6 2 1 1 3 3 3 1 Anion-transporting ATPase AAA_26 PF13500.6 EMD64574.1 - 0.00031 20.6 0.1 0.13 12.1 0.0 2.1 2 0 0 2 2 2 2 AAA domain Fer4_NifH PF00142.18 EMD64574.1 - 0.00046 19.7 0.0 0.42 10.0 0.0 2.3 2 1 0 2 2 2 2 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family AAA_25 PF13481.6 EMD64574.1 - 0.0029 17.2 0.1 0.0084 15.7 0.0 1.7 2 0 0 2 2 2 1 AAA domain MeaB PF03308.16 EMD64574.1 - 0.045 12.7 0.1 0.076 12.0 0.1 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB CBP_BcsQ PF06564.12 EMD64574.1 - 0.057 12.9 0.2 0.19 11.2 0.1 1.8 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsQ CLP1_P PF16575.5 EMD64574.1 - 0.073 12.9 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop VirC1 PF07015.11 EMD64574.1 - 0.12 11.7 0.0 0.25 10.6 0.0 1.5 2 0 0 2 2 2 0 VirC1 protein TRAUB PF08164.12 EMD64575.1 - 2.9e-30 104.6 0.1 2.1e-29 101.9 0.1 2.6 1 0 0 1 1 1 1 Apoptosis-antagonizing transcription factor, C-terminal AATF-Che1 PF13339.6 EMD64575.1 - 3.2e-27 95.9 1.7 3.2e-27 95.9 1.7 2.7 3 1 0 3 3 3 1 Apoptosis antagonizing transcription factor BSP_II PF05432.11 EMD64575.1 - 0.12 12.0 18.3 0.018 14.8 12.2 2.4 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) FAD_binding_6 PF00970.24 EMD64577.1 - 2.4e-32 111.2 0.0 4.7e-32 110.3 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 EMD64577.1 - 1.4e-29 102.9 0.0 3.4e-29 101.7 0.0 1.7 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Cyt-b5 PF00173.28 EMD64577.1 - 4.9e-21 74.7 0.0 9.8e-21 73.7 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain NAD_binding_6 PF08030.12 EMD64577.1 - 5.4e-06 26.6 0.0 4.3e-05 23.7 0.0 2.0 1 1 1 2 2 2 1 Ferric reductase NAD binding domain FAD_binding_9 PF08021.11 EMD64577.1 - 6.4e-05 23.2 0.0 0.00019 21.7 0.0 1.8 1 0 0 1 1 1 1 Siderophore-interacting FAD-binding domain PFOR_II PF17147.4 EMD64577.1 - 0.2 12.0 0.0 0.37 11.1 0.0 1.5 1 0 0 1 1 1 0 Pyruvate:ferredoxin oxidoreductase core domain II p450 PF00067.22 EMD64578.1 - 2.8e-60 204.4 0.0 3.6e-60 204.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 NAD_binding_4 PF07993.12 EMD64580.1 - 6.2e-43 146.8 0.0 1.2e-42 145.9 0.0 1.5 1 0 0 1 1 1 1 Male sterility protein AMP-binding PF00501.28 EMD64580.1 - 6.5e-25 87.6 0.0 1.1e-24 86.9 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme Epimerase PF01370.21 EMD64580.1 - 3.5e-10 39.7 0.0 6.8e-10 38.8 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family AAA_33 PF13671.6 EMD64580.1 - 4.7e-10 39.8 0.0 1.4e-09 38.3 0.0 1.8 1 0 0 1 1 1 1 AAA domain PP-binding PF00550.25 EMD64580.1 - 7.3e-08 32.6 0.0 3.6e-07 30.4 0.0 2.3 2 0 0 2 2 1 1 Phosphopantetheine attachment site AAA_18 PF13238.6 EMD64580.1 - 1.3e-07 32.2 0.0 3.3e-07 30.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain SKI PF01202.22 EMD64580.1 - 6.5e-06 26.4 0.0 1.7e-05 25.0 0.0 1.8 1 0 0 1 1 1 1 Shikimate kinase AAA_22 PF13401.6 EMD64580.1 - 0.0008 19.7 0.1 0.016 15.5 0.0 2.7 3 0 0 3 3 2 1 AAA domain Cytidylate_kin PF02224.18 EMD64580.1 - 0.00083 19.1 0.1 0.0027 17.5 0.0 1.8 1 1 0 1 1 1 1 Cytidylate kinase KR PF08659.10 EMD64580.1 - 0.0034 17.3 0.3 0.031 14.2 0.1 2.6 3 0 0 3 3 2 1 KR domain AAA_7 PF12775.7 EMD64580.1 - 0.0056 16.2 0.0 0.016 14.8 0.0 1.7 1 0 0 1 1 1 1 P-loop containing dynein motor region ABC_tran PF00005.27 EMD64580.1 - 0.0057 17.2 0.0 0.018 15.5 0.0 1.9 1 0 0 1 1 1 1 ABC transporter AAA PF00004.29 EMD64580.1 - 0.0085 16.5 0.1 0.023 15.1 0.1 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.6 EMD64580.1 - 0.011 16.2 0.1 0.045 14.2 0.1 2.2 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EMD64580.1 - 0.014 15.1 0.1 0.046 13.5 0.1 1.9 1 0 0 1 1 1 0 P-loop containing region of AAA domain KTI12 PF08433.10 EMD64580.1 - 0.025 14.0 0.0 0.076 12.4 0.0 1.8 2 0 0 2 2 2 0 Chromatin associated protein KTI12 AAA_16 PF13191.6 EMD64580.1 - 0.047 14.1 0.0 0.15 12.4 0.0 1.9 1 0 0 1 1 1 0 AAA ATPase domain AAA_30 PF13604.6 EMD64580.1 - 0.048 13.4 0.0 0.17 11.6 0.0 1.9 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 EMD64580.1 - 0.061 13.2 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase RestrictionSfiI PF11487.8 EMD64580.1 - 0.067 13.1 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 Type II restriction enzyme SfiI AAA_28 PF13521.6 EMD64580.1 - 0.079 13.2 0.0 0.2 11.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain FERM_F1 PF18379.1 EMD64580.1 - 0.098 12.7 0.1 0.23 11.5 0.1 1.5 1 0 0 1 1 1 0 FERM F1 ubiquitin-like domain APS_kinase PF01583.20 EMD64580.1 - 0.11 12.3 0.0 0.23 11.3 0.0 1.5 1 0 0 1 1 1 0 Adenylylsulphate kinase T2SSE PF00437.20 EMD64580.1 - 0.12 11.4 1.4 0.47 9.5 0.0 2.5 3 0 0 3 3 3 0 Type II/IV secretion system protein Rad17 PF03215.15 EMD64580.1 - 0.16 11.9 0.0 0.34 10.8 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain MFS_1 PF07690.16 EMD64581.1 - 3.6e-18 65.6 9.5 4.4e-18 65.3 9.5 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily SpoVAB PF13782.6 EMD64581.1 - 0.00069 19.9 1.4 0.0012 19.1 1.4 1.4 1 0 0 1 1 1 1 Stage V sporulation protein AB TraL PF07178.11 EMD64581.1 - 0.7 10.4 4.4 1 9.9 3.7 1.7 1 1 0 1 1 1 0 TraL protein Fungal_trans PF04082.18 EMD64582.1 - 9e-29 100.3 0.0 1.5e-28 99.6 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD64582.1 - 1.2e-07 31.7 10.1 3.1e-07 30.4 10.1 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Aldo_ket_red PF00248.21 EMD64583.1 - 5.5e-43 147.2 0.0 4.6e-42 144.2 0.0 1.9 1 1 0 1 1 1 1 Aldo/keto reductase family Phage_X PF05155.15 EMD64583.1 - 0.16 12.4 0.0 0.37 11.2 0.0 1.6 1 0 0 1 1 1 0 Phage X family HET PF06985.11 EMD64584.1 - 3.9e-06 27.3 2.2 0.0022 18.4 0.0 2.7 2 1 1 3 3 3 2 Heterokaryon incompatibility protein (HET) SRR1 PF07985.12 EMD64584.1 - 0.026 14.6 0.1 0.077 13.0 0.1 1.7 1 0 0 1 1 1 0 SRR1 Amidohydro_2 PF04909.14 EMD64587.1 - 1.9e-10 41.0 0.0 2.3e-10 40.8 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase Fungal_trans PF04082.18 EMD64588.1 - 5.9e-15 55.0 0.1 6.3e-15 54.9 0.1 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Spc24 PF08286.11 EMD64588.1 - 0.065 13.5 0.0 0.08 13.2 0.0 1.2 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 NTR2 PF15458.6 EMD64589.1 - 0.056 13.0 0.1 0.078 12.5 0.1 1.1 1 0 0 1 1 1 0 Nineteen complex-related protein 2 Fig1 PF12351.8 EMD64589.1 - 0.057 13.3 0.4 0.057 13.3 0.4 2.2 2 0 0 2 2 2 0 Ca2+ regulator and membrane fusion protein Fig1 Glyco_tranf_2_3 PF13641.6 EMD64590.1 - 1.3e-17 64.5 0.0 2e-17 63.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 EMD64590.1 - 5.2e-16 58.9 0.0 8.1e-16 58.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_trans_2_3 PF13632.6 EMD64590.1 - 1.1e-13 51.6 0.5 2.7e-13 50.3 0.5 1.7 1 0 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_transf_21 PF13506.6 EMD64590.1 - 1.5e-10 40.8 0.0 2.5e-10 40.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 21 Cellulose_synt PF03552.14 EMD64590.1 - 3.9e-08 32.3 0.2 0.0086 14.6 0.2 3.1 1 1 2 3 3 3 3 Cellulose synthase GNT-I PF03071.15 EMD64590.1 - 0.2 10.4 0.0 0.3 9.8 0.0 1.1 1 0 0 1 1 1 0 GNT-I family ubiquitin PF00240.23 EMD64591.1 - 1.1e-17 63.5 0.0 2.6e-17 62.3 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EMD64591.1 - 4.6e-07 29.6 0.0 1e-06 28.4 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Tyrosinase PF00264.20 EMD64592.1 - 1.2e-23 84.6 1.3 1.8e-23 84.0 1.3 1.3 1 0 0 1 1 1 1 Common central domain of tyrosinase SBF PF01758.16 EMD64593.1 - 2.1e-50 171.1 13.2 2.1e-50 171.1 13.2 2.3 3 0 0 3 3 3 1 Sodium Bile acid symporter family MFS_1 PF07690.16 EMD64593.1 - 0.64 8.9 33.9 1.5 7.7 25.7 2.8 1 1 1 2 2 2 0 Major Facilitator Superfamily Rhodanese PF00581.20 EMD64594.1 - 0.0002 21.8 0.0 0.00026 21.5 0.0 1.3 1 0 0 1 1 1 1 Rhodanese-like domain FMN_red PF03358.15 EMD64595.1 - 8.7e-12 45.0 0.0 9.6e-06 25.4 0.0 2.2 1 1 1 2 2 2 2 NADPH-dependent FMN reductase DUF3615 PF12274.8 EMD64596.1 - 0.11 13.0 0.9 0.16 12.5 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3615) DUF3328 PF11807.8 EMD64597.1 - 5e-18 65.7 0.6 5.7e-18 65.5 0.6 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) DUF3328 PF11807.8 EMD64598.1 - 0.013 15.3 0.0 0.018 14.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3328) DUF3989 PF13150.6 EMD64598.1 - 0.18 11.6 0.0 0.3 10.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3989) DUF3328 PF11807.8 EMD64599.1 - 9.8e-41 139.9 0.4 1.1e-40 139.8 0.4 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) 2OG-FeII_Oxy_3 PF13640.6 EMD64600.1 - 5e-09 36.9 0.1 7.8e-09 36.3 0.1 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF3328 PF11807.8 EMD64601.1 - 1.4e-20 74.0 4.9 5.9e-20 72.0 4.9 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF3328) Sec62 PF03839.16 EMD64602.1 - 1.8 8.1 10.0 0.094 12.2 3.6 2.1 3 0 0 3 3 3 0 Translocation protein Sec62 Lon_C PF05362.13 EMD64605.1 - 1.1e-65 221.0 0.0 2.2e-65 220.1 0.0 1.5 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain LON_substr_bdg PF02190.16 EMD64605.1 - 1.5e-31 109.9 0.0 3.8e-31 108.6 0.0 1.7 1 0 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain AAA PF00004.29 EMD64605.1 - 8.8e-22 78.0 0.0 2.3e-21 76.6 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_2 PF07724.14 EMD64605.1 - 1.5e-07 31.7 0.0 4.6e-07 30.1 0.0 1.9 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) ChlI PF13541.6 EMD64605.1 - 3e-07 30.3 0.0 7.1e-07 29.1 0.0 1.6 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase AAA_5 PF07728.14 EMD64605.1 - 4.8e-07 29.9 0.0 1.5e-06 28.3 0.0 1.9 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EMD64605.1 - 2.4e-05 24.6 0.1 0.0014 18.9 0.1 2.8 1 1 0 1 1 1 1 AAA domain AAA_PrkA PF08298.11 EMD64605.1 - 3.6e-05 22.9 0.0 6.9e-05 21.9 0.0 1.4 1 0 0 1 1 1 1 PrkA AAA domain RuvB_N PF05496.12 EMD64605.1 - 8.1e-05 22.4 0.0 0.00063 19.5 0.0 2.4 3 0 0 3 3 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EMD64605.1 - 9.7e-05 22.8 1.1 0.00067 20.1 0.1 2.7 2 1 0 2 2 2 1 AAA ATPase domain IstB_IS21 PF01695.17 EMD64605.1 - 0.0032 17.2 0.0 0.0093 15.7 0.0 1.7 2 0 0 2 2 1 1 IstB-like ATP binding protein AAA_14 PF13173.6 EMD64605.1 - 0.0091 16.0 0.0 0.026 14.6 0.0 1.8 1 0 0 1 1 1 1 AAA domain NTPase_1 PF03266.15 EMD64605.1 - 0.019 14.9 0.1 0.16 11.9 0.0 2.3 1 1 1 2 2 2 0 NTPase AAA_18 PF13238.6 EMD64605.1 - 0.024 15.2 0.0 0.024 15.2 0.0 3.3 3 0 0 3 3 2 0 AAA domain RNA_helicase PF00910.22 EMD64605.1 - 0.043 14.2 0.0 0.12 12.8 0.0 1.8 1 0 0 1 1 1 0 RNA helicase AAA_30 PF13604.6 EMD64605.1 - 0.063 13.0 0.0 0.16 11.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EMD64605.1 - 0.086 13.4 0.4 0.37 11.3 0.0 2.2 2 0 0 2 2 2 0 ABC transporter AAA_28 PF13521.6 EMD64605.1 - 0.088 13.0 0.0 20 5.4 0.0 3.0 2 0 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 EMD64605.1 - 0.095 12.6 0.0 0.23 11.3 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase AAA_7 PF12775.7 EMD64605.1 - 0.14 11.6 0.0 0.33 10.5 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region NACHT PF05729.12 EMD64605.1 - 0.18 11.7 0.0 0.85 9.5 0.0 2.2 1 1 0 1 1 1 0 NACHT domain CbiA PF01656.23 EMD64605.1 - 0.23 11.5 1.5 43 4.2 0.0 3.3 3 0 0 3 3 3 0 CobQ/CobB/MinD/ParA nucleotide binding domain Pkinase PF00069.25 EMD64607.1 - 1.8e-13 50.5 0.1 2.4e-12 46.8 0.1 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD64607.1 - 6.4e-13 48.6 0.0 7.5e-12 45.1 0.0 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase DUF3328 PF11807.8 EMD64609.1 - 1.9e-32 112.8 0.2 2.3e-32 112.6 0.2 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) CPSase_C PF18302.1 EMD64610.1 - 0.0063 16.6 0.3 32 5.5 0.0 3.6 3 0 0 3 3 3 1 Carbamoyl phosphate synthetase C-terminal domain Aconitase_C PF00694.19 EMD64610.1 - 0.079 13.3 1.3 39 4.6 0.0 3.0 1 1 2 3 3 3 0 Aconitase C-terminal domain TPR_10 PF13374.6 EMD64611.1 - 8.5e-08 31.8 0.0 8.5e-08 31.8 0.0 3.4 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_12 PF13424.6 EMD64611.1 - 1.4e-06 28.5 2.7 1.3e-05 25.4 0.0 3.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_4 PF07721.14 EMD64611.1 - 0.012 16.1 0.2 0.012 16.1 0.2 3.2 4 0 0 4 4 4 0 Tetratricopeptide repeat NB-ARC PF00931.22 EMD64611.1 - 0.015 14.5 0.0 2 7.5 0.0 2.2 2 0 0 2 2 2 0 NB-ARC domain AAA_16 PF13191.6 EMD64611.1 - 0.031 14.7 0.1 0.081 13.3 0.1 1.7 1 1 0 1 1 1 0 AAA ATPase domain ATPase_2 PF01637.18 EMD64611.1 - 0.074 13.0 0.0 0.17 11.8 0.0 1.5 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea TPR_7 PF13176.6 EMD64611.1 - 0.099 12.7 2.0 0.18 11.9 0.0 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 EMD64611.1 - 0.17 12.8 0.7 0.82 10.7 0.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF5357 PF17310.2 EMD64613.1 - 0.98 7.9 4.9 1.5 7.3 4.9 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5357) BUD22 PF09073.10 EMD64614.1 - 0.018 14.4 54.7 0.058 12.7 34.6 2.1 2 0 0 2 2 2 0 BUD22 Mitofilin PF09731.9 EMD64614.1 - 0.15 10.9 75.1 0.31 9.8 26.9 2.2 2 0 0 2 2 2 0 Mitochondrial inner membrane protein DUF572 PF04502.13 EMD64614.1 - 2 8.0 43.5 0.38 10.3 10.3 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF572) TFIIF_alpha PF05793.12 EMD64614.1 - 8.1 4.9 47.8 1 7.9 31.5 2.1 2 0 0 2 2 2 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) MAP7 PF05672.11 EMD64614.1 - 8.8 6.0 79.7 0.43 10.3 47.0 2.4 2 0 0 2 2 2 0 MAP7 (E-MAP-115) family Caldesmon PF02029.15 EMD64614.1 - 9.4 4.9 60.5 0.81 8.4 35.0 2.1 2 0 0 2 2 2 0 Caldesmon HET PF06985.11 EMD64615.1 - 1.3e-23 83.9 0.1 1.6e-23 83.7 0.1 1.1 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Acetyltransf_7 PF13508.7 EMD64616.1 - 1.3e-08 35.2 0.0 6.2e-08 33.0 0.0 1.9 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EMD64616.1 - 3.2e-07 30.3 0.0 8.7e-07 28.9 0.0 1.6 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EMD64616.1 - 5e-07 30.0 0.0 8.2e-07 29.3 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_9 PF13527.7 EMD64616.1 - 0.051 13.7 0.0 0.29 11.2 0.0 1.9 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain ThrE PF06738.12 EMD64617.1 - 2.2e-61 207.3 28.5 4.2e-61 206.4 9.5 2.6 3 0 0 3 3 3 2 Putative threonine/serine exporter ThrE_2 PF12821.7 EMD64617.1 - 8.8e-08 32.4 14.5 8.8e-08 32.4 14.5 2.9 3 0 0 3 3 3 1 Threonine/Serine exporter, ThrE bZIP_1 PF00170.21 EMD64620.1 - 6.6e-08 32.5 7.5 1.3e-07 31.6 7.5 1.4 1 0 0 1 1 1 1 bZIP transcription factor SHE3 PF17078.5 EMD64620.1 - 0.01 15.6 4.5 0.01 15.6 3.0 1.6 1 1 1 2 2 2 0 SWI5-dependent HO expression protein 3 bZIP_Maf PF03131.17 EMD64620.1 - 0.011 16.2 7.0 0.011 16.2 7.0 1.7 2 0 0 2 2 2 0 bZIP Maf transcription factor bZIP_2 PF07716.15 EMD64620.1 - 0.015 15.4 8.5 0.015 15.4 8.5 1.8 1 1 1 2 2 2 0 Basic region leucine zipper CDPS PF16715.5 EMD64620.1 - 0.056 13.1 1.2 0.077 12.6 1.2 1.2 1 0 0 1 1 1 0 Cyclodipeptide synthase V_ATPase_I PF01496.19 EMD64620.1 - 0.3 8.9 1.5 0.36 8.7 1.5 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CENP-H PF05837.12 EMD64620.1 - 0.51 10.8 3.7 0.73 10.3 3.7 1.3 1 0 0 1 1 1 0 Centromere protein H (CENP-H) DUF4407 PF14362.6 EMD64620.1 - 0.53 9.6 4.5 0.71 9.2 4.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF3678 PF12435.8 EMD64622.1 - 4.5 6.7 7.8 2.5 7.6 3.4 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3678) Coatomer_WDAD PF04053.14 EMD64626.1 - 8.5e-170 565.6 0.0 1.7e-169 564.6 0.0 1.5 2 0 0 2 2 2 1 Coatomer WD associated region WD40 PF00400.32 EMD64626.1 - 2e-36 123.4 1.3 2.8e-06 27.9 0.0 7.9 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD64626.1 - 4e-05 23.8 0.1 11 6.4 0.0 5.7 4 2 2 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EMD64626.1 - 0.00021 20.1 2.1 0.16 10.5 0.1 3.9 1 1 2 3 3 3 2 Nucleoporin Nup120/160 BBS2_Mid PF14783.6 EMD64626.1 - 0.004 17.2 0.0 3.6 7.7 0.0 3.9 2 1 1 3 3 3 1 Ciliary BBSome complex subunit 2, middle region eIF2A PF08662.11 EMD64626.1 - 0.088 12.7 0.0 5 7.0 0.0 3.2 2 1 1 3 3 3 0 Eukaryotic translation initiation factor eIF2A MetallophosC PF16370.5 EMD64626.1 - 0.094 12.9 0.4 0.95 9.7 0.0 2.6 2 1 0 2 2 2 0 C terminal of Calcineurin-like phosphoesterase WD40_like PF17005.5 EMD64626.1 - 0.1 11.9 0.0 16 4.7 0.0 3.1 3 0 0 3 3 3 0 WD40-like domain Nop14 PF04147.12 EMD64626.1 - 0.81 7.8 13.8 1 7.5 13.8 1.2 1 0 0 1 1 1 0 Nop14-like family AAA PF00004.29 EMD64627.1 - 4e-36 124.3 0.0 1.1e-35 122.9 0.0 1.8 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EMD64627.1 - 7.9e-08 32.0 0.1 1.8e-07 30.8 0.1 1.6 1 0 0 1 1 1 1 AAA+ lid domain RuvB_N PF05496.12 EMD64627.1 - 2.6e-05 24.0 0.0 6e-05 22.8 0.0 1.6 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EMD64627.1 - 3.3e-05 24.3 1.4 0.00049 20.5 0.0 2.8 2 1 1 3 3 3 1 AAA ATPase domain AAA_14 PF13173.6 EMD64627.1 - 5.9e-05 23.1 0.0 0.00015 21.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 EMD64627.1 - 8.2e-05 22.6 0.1 0.00063 19.7 0.1 2.4 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 EMD64627.1 - 0.00013 22.2 0.0 0.00032 20.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 EMD64627.1 - 0.00031 21.0 0.8 0.01 16.1 0.0 2.9 2 1 1 3 3 3 1 AAA domain AAA_33 PF13671.6 EMD64627.1 - 0.00045 20.4 0.2 0.0012 19.0 0.0 1.9 2 0 0 2 2 1 1 AAA domain IstB_IS21 PF01695.17 EMD64627.1 - 0.00076 19.2 0.0 0.0021 17.8 0.0 1.7 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_18 PF13238.6 EMD64627.1 - 0.0009 19.8 0.5 0.0037 17.8 0.0 2.3 3 0 0 3 3 2 1 AAA domain AAA_25 PF13481.6 EMD64627.1 - 0.00097 18.8 0.1 0.036 13.6 0.0 2.4 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 EMD64627.1 - 0.0012 18.3 0.1 0.0023 17.3 0.1 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 EMD64627.1 - 0.0018 18.6 0.0 0.0046 17.3 0.0 1.9 1 1 0 1 1 1 1 RNA helicase TniB PF05621.11 EMD64627.1 - 0.003 17.0 0.0 2.9 7.3 0.0 2.5 2 0 0 2 2 2 2 Bacterial TniB protein AAA_28 PF13521.6 EMD64627.1 - 0.004 17.4 0.6 0.021 15.1 0.0 2.4 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 EMD64627.1 - 0.0041 17.1 0.0 0.017 15.0 0.0 1.9 2 0 0 2 2 2 1 NACHT domain AAA_24 PF13479.6 EMD64627.1 - 0.0051 16.6 0.2 0.017 14.9 0.0 1.8 2 0 0 2 2 2 1 AAA domain Sigma54_activ_2 PF14532.6 EMD64627.1 - 0.017 15.2 0.0 0.041 14.0 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain Rad17 PF03215.15 EMD64627.1 - 0.02 14.8 0.1 0.06 13.3 0.1 1.7 1 1 0 1 1 1 0 Rad17 P-loop domain Parvo_NS1 PF01057.17 EMD64627.1 - 0.021 13.9 0.0 0.03 13.4 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Sigma54_activat PF00158.26 EMD64627.1 - 0.032 13.9 0.0 0.071 12.8 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain ABC_tran PF00005.27 EMD64627.1 - 0.04 14.4 0.8 0.098 13.2 0.0 2.0 2 0 0 2 2 2 0 ABC transporter DUF815 PF05673.13 EMD64627.1 - 0.056 12.6 0.0 0.14 11.3 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_7 PF12775.7 EMD64627.1 - 0.057 12.9 0.1 0.15 11.6 0.0 1.6 2 0 0 2 2 1 0 P-loop containing dynein motor region CPT PF07931.12 EMD64627.1 - 0.073 12.9 0.0 0.18 11.7 0.0 1.6 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein Viral_helicase1 PF01443.18 EMD64627.1 - 0.11 12.3 0.0 0.24 11.1 0.0 1.6 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase TsaE PF02367.17 EMD64627.1 - 0.11 12.5 0.0 0.2 11.6 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATPase_2 PF01637.18 EMD64627.1 - 0.19 11.6 1.5 0.27 11.1 0.0 2.0 2 1 0 2 2 1 0 ATPase domain predominantly from Archaea SKI PF01202.22 EMD64627.1 - 0.69 10.0 0.0 0.69 10.0 0.0 2.8 3 0 0 3 3 3 0 Shikimate kinase AAA_11 PF13086.6 EMD64627.1 - 0.75 9.5 6.9 0.77 9.5 1.6 2.8 2 1 0 2 2 2 0 AAA domain Astro_capsid_p PF12226.8 EMD64627.1 - 4.4 6.4 12.6 1.5 7.9 8.6 1.9 2 0 0 2 2 2 0 Turkey astrovirus capsid protein TIM21 PF08294.11 EMD64628.1 - 1.8e-40 138.2 0.0 2.4e-40 137.7 0.0 1.1 1 0 0 1 1 1 1 TIM21 Coa1 PF08695.10 EMD64628.1 - 7.3e-09 35.4 0.0 1.4e-08 34.4 0.0 1.5 1 1 0 1 1 1 1 Cytochrome oxidase complex assembly protein 1 AltA1 PF16541.5 EMD64629.1 - 0.0043 17.9 0.4 0.0071 17.2 0.4 1.4 1 1 0 1 1 1 1 Alternaria alternata allergen 1 Syntaxin-18_N PF10496.9 EMD64630.1 - 7.4e-11 42.2 0.6 7.4e-11 42.2 0.6 3.1 3 0 0 3 3 3 1 SNARE-complex protein Syntaxin-18 N-terminus SNARE PF05739.19 EMD64630.1 - 0.00011 22.1 0.0 0.00039 20.4 0.0 1.9 1 0 0 1 1 1 1 SNARE domain DUF2935 PF11155.8 EMD64630.1 - 0.04 14.3 0.4 2.3 8.5 0.5 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF2935) TubC_N PF18563.1 EMD64630.1 - 0.11 12.5 0.9 0.35 10.9 0.1 2.3 2 0 0 2 2 2 0 TubC N-terminal docking domain TORC_N PF12884.7 EMD64630.1 - 0.25 12.1 0.1 0.25 12.1 0.1 2.6 3 1 1 4 4 4 0 Transducer of regulated CREB activity, N terminus PKK PF12474.8 EMD64630.1 - 1.8 8.7 16.1 1.9 8.6 3.6 2.4 2 0 0 2 2 2 0 Polo kinase kinase KELK PF15796.5 EMD64630.1 - 2.1 8.9 18.7 0.48 10.9 2.3 3.7 3 1 1 4 4 4 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase Syntaxin PF00804.25 EMD64630.1 - 5.6 6.6 13.4 0.18 11.4 1.7 3.1 2 1 1 3 3 3 0 Syntaxin Aminotran_1_2 PF00155.21 EMD64631.1 - 8.1e-84 281.9 0.0 9.4e-84 281.7 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Retrotran_gag_3 PF14244.6 EMD64632.1 - 0.00012 21.9 0.0 0.0002 21.1 0.0 1.3 1 0 0 1 1 1 1 gag-polypeptide of LTR copia-type Retrotran_gag_2 PF14223.6 EMD64632.1 - 0.022 14.4 0.0 0.053 13.2 0.0 1.6 1 1 0 1 1 1 0 gag-polypeptide of LTR copia-type ArdA PF07275.11 EMD64632.1 - 0.1 13.1 0.0 0.15 12.7 0.0 1.2 1 0 0 1 1 1 0 Antirestriction protein (ArdA) ACPS PF01648.20 EMD64633.1 - 7.2e-12 45.5 0.1 9.2e-12 45.1 0.1 1.3 1 1 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily 4PPT_N PF17837.1 EMD64633.1 - 0.00065 19.8 0.4 0.92 9.7 0.1 2.5 2 0 0 2 2 2 2 4'-phosphopantetheinyl transferase N-terminal domain DUF3433 PF11915.8 EMD64634.1 - 1.3e-16 60.9 2.6 1.3e-16 60.9 2.6 2.7 3 0 0 3 3 3 1 Protein of unknown function (DUF3433) FKBP_C PF00254.28 EMD64637.1 - 1.2e-19 70.5 0.0 1.4e-19 70.2 0.0 1.1 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase PHP PF02811.19 EMD64638.1 - 1.4e-16 61.2 0.1 4.2e-16 59.7 0.2 1.8 2 1 0 2 2 2 1 PHP domain AIG2_2 PF13772.6 EMD64639.1 - 2.1e-07 31.2 0.0 2.5e-06 27.8 0.0 2.4 1 1 0 1 1 1 1 AIG2-like family GGACT PF06094.12 EMD64639.1 - 0.0028 18.3 0.0 0.0047 17.5 0.0 1.5 1 0 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like DUF5435 PF17503.2 EMD64639.1 - 0.23 11.2 0.8 0.35 10.6 0.8 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5435) BAR_2 PF10455.9 EMD64640.1 - 9.7e-63 212.0 0.3 1.4e-62 211.5 0.3 1.2 1 0 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking BAR PF03114.18 EMD64640.1 - 7.3e-21 74.9 2.8 1e-19 71.2 2.8 2.0 1 1 0 1 1 1 1 BAR domain BAR_3 PF16746.5 EMD64640.1 - 0.01 15.6 0.1 0.074 12.7 0.0 2.3 2 0 0 2 2 2 0 BAR domain of APPL family Zn_clus PF00172.18 EMD64641.1 - 8.7e-08 32.2 10.2 1.4e-07 31.5 10.2 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EMD64641.1 - 0.00013 20.9 0.3 0.00032 19.6 0.2 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain BUD22 PF09073.10 EMD64641.1 - 0.29 10.4 11.4 0.44 9.8 11.4 1.2 1 0 0 1 1 1 0 BUD22 zf-RING_2 PF13639.6 EMD64643.1 - 8.7e-11 42.0 8.6 1.3e-10 41.4 8.6 1.3 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 EMD64643.1 - 1.2e-08 35.1 6.8 2e-08 34.4 6.8 1.3 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 EMD64643.1 - 1.2e-06 28.2 8.4 1.9e-06 27.6 8.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMD64643.1 - 4.5e-05 23.2 8.5 6.8e-05 22.7 8.5 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EMD64643.1 - 5.8e-05 23.1 3.0 9.9e-05 22.3 3.0 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.5 EMD64643.1 - 7.5e-05 22.4 7.8 0.00014 21.5 7.8 1.4 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_5 PF14634.6 EMD64643.1 - 0.00035 20.5 6.6 0.00051 19.9 6.6 1.3 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EMD64643.1 - 0.0025 17.6 6.2 0.0041 16.9 6.2 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 Zn_ribbon_17 PF17120.5 EMD64643.1 - 0.0027 17.3 5.4 0.0046 16.6 5.4 1.3 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-C3HC4_3 PF13920.6 EMD64643.1 - 0.031 14.1 5.2 0.052 13.4 5.2 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EMD64643.1 - 0.15 12.1 7.1 0.3 11.1 7.1 1.5 1 0 0 1 1 1 0 RING-type zinc-finger DUF1272 PF06906.11 EMD64643.1 - 0.17 12.0 3.4 0.32 11.1 3.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) FANCL_C PF11793.8 EMD64643.1 - 0.32 11.2 5.1 0.58 10.4 5.1 1.4 1 0 0 1 1 1 0 FANCL C-terminal domain RINGv PF12906.7 EMD64643.1 - 0.38 10.9 9.2 0.59 10.3 9.2 1.3 1 0 0 1 1 1 0 RING-variant domain zf-RING_4 PF14570.6 EMD64643.1 - 0.47 10.3 7.2 0.75 9.6 7.2 1.3 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING-like PF08746.11 EMD64643.1 - 0.5 10.7 4.3 0.84 10.0 4.3 1.4 1 0 0 1 1 1 0 RING-like domain zf-Nse PF11789.8 EMD64643.1 - 0.67 9.8 3.9 1.2 9.0 3.9 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit RNA_pol_I_TF PF04090.12 EMD64644.1 - 2.6e-10 40.1 0.0 2e-09 37.3 0.0 2.0 1 1 0 1 1 1 1 RNA polymerase I specific initiation factor TPR_2 PF07719.17 EMD64644.1 - 0.46 10.7 2.4 51 4.3 1.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat FAD_binding_3 PF01494.19 EMD64645.1 - 1.1e-93 314.3 0.0 1.4e-93 313.9 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Phe_hydrox_dim PF07976.12 EMD64645.1 - 2.2e-46 158.0 0.0 4.2e-46 157.0 0.0 1.5 1 0 0 1 1 1 1 Phenol hydroxylase, C-terminal dimerisation domain Pyr_redox_2 PF07992.14 EMD64645.1 - 0.00036 19.9 0.2 0.0013 18.1 0.1 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EMD64645.1 - 0.00042 19.2 0.2 0.0006 18.6 0.2 1.2 1 0 0 1 1 1 1 HI0933-like protein FAD_binding_2 PF00890.24 EMD64645.1 - 0.00045 19.4 0.2 0.00078 18.6 0.2 1.3 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 EMD64645.1 - 0.0093 16.2 0.0 0.12 12.6 0.0 2.6 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 EMD64645.1 - 0.012 14.7 0.1 0.021 13.9 0.1 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein Pyr_redox_3 PF13738.6 EMD64645.1 - 0.016 14.5 0.2 0.027 13.7 0.2 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EMD64645.1 - 0.018 14.6 0.0 1.2 8.7 0.0 2.8 3 0 0 3 3 3 0 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.21 EMD64645.1 - 0.13 11.5 0.0 0.2 10.9 0.0 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain SE PF08491.10 EMD64645.1 - 0.2 10.7 0.0 3 6.8 0.0 2.0 2 0 0 2 2 2 0 Squalene epoxidase GIDA PF01134.22 EMD64645.1 - 0.22 10.6 0.2 0.34 9.9 0.2 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A Trp_halogenase PF04820.14 EMD64645.1 - 0.32 9.8 1.2 5.7 5.7 0.2 2.5 3 0 0 3 3 3 0 Tryptophan halogenase Chitin_synth_1 PF01644.17 EMD64646.1 - 5.6e-78 260.5 0.1 8.7e-78 259.9 0.1 1.3 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.11 EMD64646.1 - 1.7e-26 91.9 0.1 3.7e-26 90.9 0.1 1.6 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.15 EMD64646.1 - 1.2e-22 80.3 0.3 9.1e-20 70.8 0.0 2.3 2 0 0 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.6 EMD64646.1 - 8.8e-07 29.0 0.8 8.8e-07 29.0 0.8 2.2 3 1 0 3 3 3 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 EMD64646.1 - 0.061 13.2 0.0 0.18 11.6 0.0 1.7 2 0 0 2 2 2 0 Glycosyltransferase like family 2 Csm1 PF12539.8 EMD64647.1 - 4.9e-28 97.6 0.1 9.6e-28 96.6 0.1 1.5 1 0 0 1 1 1 1 Chromosome segregation protein Csm1/Pcs1 YabA PF06156.13 EMD64647.1 - 0.00052 20.6 7.4 0.0034 18.0 3.4 2.8 1 1 1 2 2 2 1 Initiation control protein YabA APG6_N PF17675.1 EMD64647.1 - 0.0018 18.8 13.3 0.0018 18.8 13.3 2.3 2 1 0 2 2 1 1 Apg6 coiled-coil region GAS PF13851.6 EMD64647.1 - 0.0027 17.1 14.9 0.018 14.4 6.2 2.4 1 1 1 2 2 2 2 Growth-arrest specific micro-tubule binding MPS2 PF17060.5 EMD64647.1 - 0.016 14.5 1.8 0.037 13.3 1.8 1.5 1 0 0 1 1 1 0 Monopolar spindle protein 2 Trypan_PARP PF05887.11 EMD64647.1 - 0.02 14.9 35.4 0.17 11.8 10.2 2.9 1 1 2 3 3 3 0 Procyclic acidic repetitive protein (PARP) Atg14 PF10186.9 EMD64647.1 - 0.026 13.6 6.9 0.053 12.6 6.9 1.5 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Rootletin PF15035.6 EMD64647.1 - 0.058 13.4 7.6 0.18 11.8 7.6 1.8 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion DUF5094 PF17015.5 EMD64647.1 - 0.07 13.2 0.0 0.07 13.2 0.0 3.9 3 1 1 4 4 3 0 Domain of unknown function (DUF5094) Gly_acyl_tr_N PF06021.11 EMD64647.1 - 0.11 12.6 2.3 0.28 11.3 2.3 1.6 1 0 0 1 1 1 0 Aralkyl acyl-CoA:amino acid N-acyltransferase DUF480 PF04337.12 EMD64647.1 - 0.12 12.5 2.6 0.26 11.4 2.6 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF480 Matrilin_ccoil PF10393.9 EMD64647.1 - 0.22 11.4 2.4 0.51 10.2 0.2 2.6 2 0 0 2 2 2 0 Trimeric coiled-coil oligomerisation domain of matrilin SKA2 PF16740.5 EMD64647.1 - 0.33 10.7 11.9 0.4 10.5 2.3 3.2 2 1 1 3 3 3 0 Spindle and kinetochore-associated protein 2 TEX13 PF15186.6 EMD64647.1 - 1.1 8.9 7.4 2.4 7.8 7.4 1.6 1 0 0 1 1 1 0 Testis-expressed sequence 13 protein family SlyX PF04102.12 EMD64647.1 - 1.4 9.6 7.1 9.4e+02 0.5 7.0 3.9 1 1 0 1 1 1 0 SlyX DivIC PF04977.15 EMD64647.1 - 2.1 8.2 10.3 0.36 10.6 3.0 3.1 1 1 1 2 2 2 0 Septum formation initiator MerR-DNA-bind PF09278.11 EMD64647.1 - 2.5 8.7 4.9 25 5.5 2.3 2.6 2 0 0 2 2 2 0 MerR, DNA binding NPV_P10 PF05531.12 EMD64647.1 - 2.6 8.6 5.8 44 4.6 3.1 2.7 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein Csm1_N PF18504.1 EMD64647.1 - 4.3 7.8 13.2 1.8 9.0 2.4 3.8 1 1 2 3 3 3 0 Csm1 N-terminal domain Mt_ATP-synt_B PF05405.14 EMD64647.1 - 5.9 6.5 11.4 1.5 8.4 7.6 1.9 2 0 0 2 2 2 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) TMPIT PF07851.13 EMD64647.1 - 7.7 5.7 7.9 14 4.8 7.9 1.4 1 0 0 1 1 1 0 TMPIT-like protein ATP19 PF11022.8 EMD64648.1 - 5.3e-28 97.2 0.2 5.9e-28 97.0 0.2 1.0 1 0 0 1 1 1 1 ATP synthase subunit K MTP18 PF10558.9 EMD64649.1 - 1.1e-80 269.6 0.0 1.6e-80 269.1 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial 18 KDa protein (MTP18) DEAD PF00270.29 EMD64650.1 - 1.2e-20 74.0 0.0 2e-20 73.3 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EMD64650.1 - 3.1e-20 72.6 0.0 2.1e-16 60.3 0.0 2.7 3 0 0 3 3 3 2 Helicase conserved C-terminal domain RecQ_Zn_bind PF16124.5 EMD64650.1 - 1.9e-05 25.3 0.2 3.9e-05 24.3 0.2 1.5 1 0 0 1 1 1 1 RecQ zinc-binding HATPase_c PF02518.26 EMD64651.1 - 2.1e-24 86.2 0.0 7.6e-24 84.4 0.0 2.0 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EMD64651.1 - 5.3e-19 68.4 0.4 1.8e-10 41.0 0.6 3.5 2 1 0 2 2 2 2 Response regulator receiver domain PAS_3 PF08447.12 EMD64651.1 - 1.1e-15 57.7 0.0 7.7e-08 32.5 0.0 2.7 2 0 0 2 2 2 2 PAS fold PAS_9 PF13426.7 EMD64651.1 - 1.2e-14 54.4 0.0 1.4e-06 28.5 0.0 3.0 3 0 0 3 3 3 2 PAS domain PAS_4 PF08448.10 EMD64651.1 - 8.8e-14 51.7 0.0 6.2e-06 26.4 0.0 4.0 6 0 0 6 6 6 2 PAS fold PAS PF00989.25 EMD64651.1 - 5.1e-10 39.3 0.0 0.00024 21.1 0.0 2.5 2 0 0 2 2 2 2 PAS fold HisKA PF00512.25 EMD64651.1 - 6.7e-07 29.3 0.1 3.4e-06 27.0 0.1 2.3 1 1 0 1 1 1 1 His Kinase A (phospho-acceptor) domain PAS_8 PF13188.7 EMD64651.1 - 0.00018 21.5 0.0 0.26 11.4 0.0 2.8 2 0 0 2 2 2 2 PAS domain PAS_11 PF14598.6 EMD64651.1 - 0.018 15.2 0.0 0.35 11.0 0.0 2.7 3 0 0 3 3 3 0 PAS domain HET PF06985.11 EMD64653.1 - 2.6e-38 131.7 3.3 3.3e-38 131.3 3.3 1.1 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) zf-AN1 PF01428.16 EMD64654.1 - 1.1e-23 83.1 23.3 3.8e-12 46.2 8.0 2.2 2 0 0 2 2 2 2 AN1-like Zinc finger Transp_Tc5_C PF04236.15 EMD64654.1 - 0.0087 16.4 12.8 0.39 11.1 1.2 2.4 2 0 0 2 2 2 2 Tc5 transposase C-terminal domain IBR PF01485.21 EMD64654.1 - 0.011 15.9 4.0 0.011 15.9 4.0 2.7 2 1 0 2 2 2 0 IBR domain, a half RING-finger domain TruB_N PF01509.18 EMD64657.1 - 4.8e-39 134.1 0.0 9.6e-39 133.1 0.0 1.5 1 0 0 1 1 1 1 TruB family pseudouridylate synthase (N terminal domain) TruB_C_2 PF16198.5 EMD64657.1 - 0.00023 21.2 0.0 0.00048 20.2 0.0 1.6 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain DUF5543 PF17697.1 EMD64657.1 - 0.039 14.2 0.9 0.078 13.3 0.9 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5543) zf-C2H2_3rep PF18868.1 EMD64658.1 - 0.0012 19.5 1.1 0.18 12.5 0.6 2.9 3 0 0 3 3 3 1 Zinc finger C2H2-type, 3 repeats zf-C2H2_4 PF13894.6 EMD64658.1 - 0.0058 17.4 22.4 0.006 17.3 4.9 4.6 4 0 0 4 4 4 2 C2H2-type zinc finger zf-C2H2 PF00096.26 EMD64658.1 - 0.086 13.3 21.1 0.77 10.3 1.7 4.8 3 1 1 4 4 4 0 Zinc finger, C2H2 type Elf1 PF05129.13 EMD64658.1 - 1.1 9.3 7.1 0.67 10.0 4.4 2.0 2 1 0 2 2 2 0 Transcription elongation factor Elf1 like CCDC106 PF15794.5 EMD64658.1 - 1.2 8.8 6.2 2 8.0 6.2 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 ketoacyl-synt PF00109.26 EMD64659.1 - 2.7e-54 184.4 0.0 3.8e-48 164.3 0.0 2.5 1 1 1 2 2 2 2 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 EMD64659.1 - 9.4e-34 116.0 0.2 3.6e-33 114.1 0.1 2.1 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain HTH_51 PF18558.1 EMD64659.1 - 2e-18 66.1 1.1 8.2e-18 64.1 0.1 2.6 3 0 0 3 3 3 1 Helix-turn-helix domain Thiolase_N PF00108.23 EMD64659.1 - 7.1e-07 28.8 0.1 1.6e-06 27.7 0.1 1.5 1 0 0 1 1 1 1 Thiolase, N-terminal domain PP-binding PF00550.25 EMD64659.1 - 5.9e-06 26.6 0.9 1.8e-05 25.0 0.9 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site KAsynt_C_assoc PF16197.5 EMD64659.1 - 1.3e-05 25.6 0.0 3.4e-05 24.2 0.0 1.7 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension PS-DH PF14765.6 EMD64659.1 - 0.011 14.9 0.0 0.022 14.0 0.0 1.4 1 0 0 1 1 1 0 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 EMD64659.1 - 0.12 11.8 0.0 0.3 10.5 0.0 1.6 1 0 0 1 1 1 0 Acyl transferase domain DUF2433 PF10360.9 EMD64660.1 - 0.037 14.1 0.0 0.11 12.6 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2433) SlyX PF04102.12 EMD64660.1 - 0.071 13.7 0.2 0.21 12.2 0.0 1.8 2 0 0 2 2 2 0 SlyX Dpoe2NT PF12213.8 EMD64660.1 - 0.095 13.0 0.2 2.1 8.7 0.0 2.2 2 0 0 2 2 2 0 DNA polymerases epsilon N terminal Polysacc_deac_1 PF01522.21 EMD64661.1 - 9.5e-31 106.3 0.0 1.5e-30 105.6 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase Chitin_bind_1 PF00187.19 EMD64661.1 - 3.4e-20 72.2 74.2 5.2e-07 30.0 15.3 3.7 3 0 0 3 3 3 3 Chitin recognition protein DUF2334 PF10096.9 EMD64661.1 - 0.0046 16.6 0.0 0.02 14.6 0.0 1.8 2 0 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2334) Glyco_hydro_57 PF03065.15 EMD64661.1 - 0.12 11.6 0.0 0.23 10.6 0.0 1.4 1 1 0 1 1 1 0 Glycosyl hydrolase family 57 Aminotran_1_2 PF00155.21 EMD64662.1 - 4.4e-36 124.8 0.0 7.2e-36 124.1 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Rad4 PF03835.15 EMD64662.1 - 7e-33 113.4 0.1 7e-33 113.4 0.1 2.3 2 0 0 2 2 2 1 Rad4 transglutaminase-like domain BHD_3 PF10405.9 EMD64662.1 - 3.6e-29 101.0 0.2 8e-29 99.9 0.2 1.6 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 3 BHD_1 PF10403.9 EMD64662.1 - 5.6e-17 61.3 1.1 8.9e-17 60.7 0.0 2.0 2 0 0 2 2 2 1 Rad4 beta-hairpin domain 1 BHD_2 PF10404.9 EMD64662.1 - 2.1e-14 54.2 1.7 2.1e-14 54.2 1.7 4.4 4 0 0 4 4 4 1 Rad4 beta-hairpin domain 2 Beta_elim_lyase PF01212.21 EMD64662.1 - 0.027 13.7 0.0 0.065 12.5 0.0 1.5 1 0 0 1 1 1 0 Beta-eliminating lyase Transglut_core PF01841.19 EMD64662.1 - 0.14 12.6 0.0 0.48 10.9 0.0 1.9 1 0 0 1 1 1 0 Transglutaminase-like superfamily zf-C2H2 PF00096.26 EMD64663.1 - 8e-12 44.9 18.5 6.1e-05 23.2 1.2 3.5 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMD64663.1 - 1.2e-07 32.0 16.3 0.012 16.4 1.0 3.4 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EMD64663.1 - 4.3e-07 29.8 8.0 0.00017 21.5 0.1 3.4 3 0 0 3 3 3 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EMD64663.1 - 1.2e-06 28.6 1.4 1.2e-06 28.6 1.4 3.4 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_8 PF15909.5 EMD64663.1 - 0.033 14.5 1.8 0.16 12.3 0.8 2.0 1 1 1 2 2 2 0 C2H2-type zinc ribbon FOXP-CC PF16159.5 EMD64663.1 - 0.054 14.1 7.1 0.12 13.0 1.2 2.5 2 1 0 2 2 2 0 FOXP coiled-coil domain zf-Di19 PF05605.12 EMD64663.1 - 0.3 11.4 9.5 0.13 12.6 3.4 2.2 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Zn-ribbon_8 PF09723.10 EMD64663.1 - 3.4 7.9 6.7 1.1 9.4 3.3 2.0 2 0 0 2 2 2 0 Zinc ribbon domain FAD_binding_4 PF01565.23 EMD64664.1 - 6.7e-29 100.4 0.6 1.2e-28 99.5 0.6 1.5 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EMD64664.1 - 0.0065 16.6 0.0 0.017 15.2 0.0 1.8 1 0 0 1 1 1 1 Berberine and berberine like Methuselah_N PF06652.12 EMD64666.1 - 0.096 12.6 0.3 0.12 12.2 0.3 1.2 1 0 0 1 1 1 0 Methuselah N-terminus Mit_ribos_Mrp51 PF11709.8 EMD64667.1 - 4e-118 395.2 0.3 4.7e-118 395.0 0.3 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein subunit RPAP2_Rtr1 PF04181.13 EMD64668.1 - 1.1e-21 76.9 0.1 1.9e-21 76.1 0.1 1.4 1 0 0 1 1 1 1 Rtr1/RPAP2 family SH3_1 PF00018.28 EMD64669.1 - 2.2e-10 40.0 0.2 4.9e-10 38.9 0.2 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EMD64669.1 - 1.9e-09 37.2 0.4 3.7e-09 36.3 0.4 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EMD64669.1 - 4.2e-09 36.0 0.1 8.9e-09 34.9 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain MFS_1 PF07690.16 EMD64670.1 - 1e-37 129.9 44.8 1e-37 129.9 44.8 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EMD64670.1 - 1.7e-07 30.5 30.6 3.1e-06 26.3 30.7 2.7 1 1 0 1 1 1 1 Sugar (and other) transporter PMP1_2 PF08114.11 EMD64670.1 - 0.039 13.7 0.6 0.15 11.8 0.0 2.3 2 0 0 2 2 2 0 ATPase proteolipid family Ribosomal_L29 PF00831.23 EMD64671.1 - 0.031 14.2 0.2 0.053 13.5 0.2 1.4 1 0 0 1 1 1 0 Ribosomal L29 protein Phage_lysozyme PF00959.19 EMD64671.1 - 0.12 12.8 0.1 2 8.9 0.0 2.2 1 1 1 2 2 2 0 Phage lysozyme peroxidase PF00141.23 EMD64672.1 - 1.4e-29 103.5 0.2 2e-29 102.9 0.2 1.2 1 0 0 1 1 1 1 Peroxidase GFA PF04828.14 EMD64674.1 - 9.8e-19 67.5 2.5 6.4e-08 32.8 0.2 3.4 3 0 0 3 3 3 3 Glutathione-dependent formaldehyde-activating enzyme Pkinase PF00069.25 EMD64675.1 - 7.5e-06 25.5 0.0 1.1e-05 24.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD64675.1 - 3.7e-05 23.1 0.0 5.8e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase DUF1077 PF06417.12 EMD64676.1 - 1.6e-46 157.1 0.7 2e-46 156.8 0.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1077) TMEM171 PF15471.6 EMD64676.1 - 0.33 9.9 3.1 0.35 9.8 2.7 1.3 1 1 0 1 1 1 0 Transmembrane protein family 171 Adaptin_N PF01602.20 EMD64677.1 - 1.5e-121 406.5 9.5 1.9e-121 406.2 9.5 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EMD64677.1 - 9.4e-58 194.8 0.4 9.4e-58 194.8 0.4 3.3 3 1 1 4 4 4 1 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 EMD64677.1 - 3.3e-13 48.7 1.1 0.00057 19.9 0.0 5.4 5 0 0 5 5 5 3 HEAT repeat HEAT_2 PF13646.6 EMD64677.1 - 7.1e-12 45.6 4.9 2.1e-07 31.3 0.1 4.3 4 1 0 4 4 4 3 HEAT repeats CLASP_N PF12348.8 EMD64677.1 - 7.8e-05 22.4 2.2 0.027 14.0 0.0 3.7 4 0 0 4 4 4 2 CLASP N terminal HEAT_EZ PF13513.6 EMD64677.1 - 0.00014 22.3 0.7 0.58 10.7 0.0 5.0 4 1 1 5 5 5 1 HEAT-like repeat Arm PF00514.23 EMD64677.1 - 0.0017 18.4 2.7 2.8 8.1 0.1 4.2 4 0 0 4 4 4 2 Armadillo/beta-catenin-like repeat RTP1_C1 PF10363.9 EMD64677.1 - 0.0054 16.9 1.8 1.8 8.8 0.1 3.4 2 1 1 3 3 3 1 Required for nuclear transport of RNA pol II C-terminus 1 DUF2496 PF10689.9 EMD64677.1 - 0.027 14.2 0.3 0.11 12.4 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2496) DUF3453 PF11935.8 EMD64677.1 - 0.049 13.3 0.0 0.26 10.9 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3453) DNA_alkylation PF08713.11 EMD64677.1 - 0.094 12.4 0.1 45 3.7 0.0 3.4 2 2 0 3 3 3 0 DNA alkylation repair enzyme DUF1774 PF08611.10 EMD64678.1 - 4.4e-32 110.3 0.0 4.4e-32 110.3 0.0 2.9 2 1 1 3 3 3 1 Fungal protein of unknown function (DUF1774) Na_Pi_cotrans PF02690.15 EMD64678.1 - 6.4 6.9 9.1 0.074 13.2 0.9 2.0 3 0 0 3 3 3 0 Na+/Pi-cotransporter Hist_deacetyl PF00850.19 EMD64679.1 - 2e-53 181.8 0.1 3.7e-53 181.0 0.1 1.4 1 0 0 1 1 1 1 Histone deacetylase domain MAD PF05557.13 EMD64680.1 - 0.0032 15.9 0.9 0.0039 15.6 0.9 1.0 1 0 0 1 1 1 1 Mitotic checkpoint protein Rab5-bind PF09311.11 EMD64680.1 - 0.0055 16.1 0.3 0.0067 15.9 0.3 1.2 1 0 0 1 1 1 1 Rabaptin-like protein Cdc6_C PF09079.11 EMD64680.1 - 0.017 15.1 0.3 0.028 14.4 0.3 1.3 1 0 0 1 1 1 0 CDC6, C terminal winged helix domain Phage_Mu_Gam PF07352.12 EMD64680.1 - 0.023 14.6 0.1 0.037 13.9 0.1 1.3 1 0 0 1 1 1 0 Bacteriophage Mu Gam like protein DMPK_coil PF08826.10 EMD64680.1 - 0.024 14.7 0.3 0.049 13.7 0.3 1.5 1 0 0 1 1 1 0 DMPK coiled coil domain like Macoilin PF09726.9 EMD64680.1 - 0.031 12.9 0.3 0.036 12.6 0.3 1.1 1 0 0 1 1 1 0 Macoilin family DUF4253 PF14062.6 EMD64681.1 - 0.084 13.0 0.0 0.77 10.0 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4253) DUF1490 PF07371.12 EMD64681.1 - 0.12 12.5 0.4 0.25 11.5 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1490) DUF202 PF02656.15 EMD64682.1 - 0.074 13.5 0.8 0.14 12.6 0.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF202) Ribosomal_S17e PF00833.18 EMD64683.1 - 6.6e-60 200.4 0.7 8.5e-60 200.0 0.7 1.1 1 0 0 1 1 1 1 Ribosomal S17 GUCT PF08152.12 EMD64683.1 - 0.12 12.7 0.0 0.16 12.3 0.0 1.2 1 0 0 1 1 1 0 GUCT (NUC152) domain Na_Ca_ex PF01699.24 EMD64684.1 - 3.3e-27 95.3 27.2 7e-14 52.0 12.3 2.1 2 0 0 2 2 2 2 Sodium/calcium exchanger protein GerA PF03323.13 EMD64684.1 - 0.0026 16.3 0.3 0.0051 15.3 0.3 1.4 1 0 0 1 1 1 1 Bacillus/Clostridium GerA spore germination protein MIG-14_Wnt-bd PF06664.12 EMD64684.1 - 0.012 14.8 0.0 0.012 14.8 0.0 1.9 2 1 0 2 2 2 0 Wnt-binding factor required for Wnt secretion Spore_YabQ PF09578.10 EMD64684.1 - 0.034 14.4 0.1 0.034 14.4 0.1 2.6 3 1 0 3 3 3 0 Spore cortex protein YabQ (Spore_YabQ) DUF4577 PF15145.6 EMD64684.1 - 0.18 11.9 1.5 0.84 9.7 1.4 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4577) DUF4396 PF14342.6 EMD64684.1 - 0.71 10.2 5.6 0.57 10.5 0.8 3.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4396) EI24 PF07264.11 EMD64684.1 - 7.8 6.7 16.0 3.9e+03 -2.1 16.1 3.1 1 1 0 1 1 1 0 Etoposide-induced protein 2.4 (EI24) Peptidase_M28 PF04389.17 EMD64685.1 - 1.2e-38 132.8 0.0 2e-38 132.1 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 EMD64685.1 - 3.6e-11 42.9 0.1 8.1e-11 41.8 0.1 1.6 1 0 0 1 1 1 1 PA domain Peptidase_M20 PF01546.28 EMD64685.1 - 0.00078 19.2 0.0 0.0013 18.5 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 FAD_binding_3 PF01494.19 EMD64686.1 - 1.8e-19 70.2 0.0 2.4e-19 69.8 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.27 EMD64686.1 - 8.3e-05 23.1 0.0 0.87 10.2 0.1 2.7 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EMD64686.1 - 0.0006 19.5 0.0 0.075 12.6 0.0 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EMD64686.1 - 0.0078 15.5 0.0 0.26 10.5 0.1 2.2 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EMD64686.1 - 0.012 15.8 0.1 0.05 13.8 0.0 2.0 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Mqo PF06039.15 EMD64686.1 - 0.029 12.9 0.0 1.3 7.4 0.0 2.1 2 0 0 2 2 2 0 Malate:quinone oxidoreductase (Mqo) TGT PF01702.18 EMD64687.1 - 4.1e-141 470.2 0.0 4.7e-141 470.0 0.0 1.0 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase Fungal_trans PF04082.18 EMD64689.1 - 0.13 11.2 0.2 0.23 10.4 0.2 1.4 1 0 0 1 1 1 0 Fungal specific transcription factor domain Ribosomal_S4Pg PF11993.8 EMD64690.1 - 0.027 14.5 0.1 0.033 14.2 0.1 1.2 1 0 0 1 1 1 0 Ribosomal S4P (gammaproteobacterial) MFS_1 PF07690.16 EMD64691.1 - 4.6e-38 131.1 19.9 3.1e-29 102.0 3.9 2.6 2 1 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EMD64691.1 - 1.8e-12 46.9 9.0 1.8e-12 46.9 9.0 2.8 3 0 0 3 3 3 1 Sugar (and other) transporter Ntox1 PF15500.6 EMD64691.1 - 0.11 12.9 0.2 0.21 12.0 0.2 1.4 1 0 0 1 1 1 0 Putative RNase-like toxin, toxin_1 AFG1_ATPase PF03969.16 EMD64692.1 - 9.2e-89 297.8 0.0 1.5e-84 284.0 0.0 2.4 2 1 0 2 2 2 2 AFG1-like ATPase DHHC PF01529.20 EMD64692.1 - 3.5e-34 117.8 8.2 3.5e-34 117.8 8.2 2.4 3 0 0 3 3 3 1 DHHC palmitoyltransferase Ank_2 PF12796.7 EMD64692.1 - 1e-31 109.4 0.1 6.2e-11 42.7 0.0 3.1 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EMD64692.1 - 1.4e-22 79.4 0.9 5e-07 29.9 0.0 4.7 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank_4 PF13637.6 EMD64692.1 - 2.2e-22 79.1 2.4 1e-06 29.2 0.2 4.6 2 1 3 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.30 EMD64692.1 - 2.6e-20 71.9 2.1 0.00024 21.4 0.4 5.5 5 0 0 5 5 5 4 Ankyrin repeat Ank_3 PF13606.6 EMD64692.1 - 3.6e-15 54.6 6.4 8.7e-06 25.7 0.2 6.0 6 0 0 6 6 6 3 Ankyrin repeat AAA_14 PF13173.6 EMD64692.1 - 0.0073 16.3 0.0 0.02 14.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain YfhO PF09586.10 EMD64692.1 - 0.28 9.4 3.8 0.4 8.9 3.8 1.1 1 0 0 1 1 1 0 Bacterial membrane protein YfhO DUF5337 PF17272.2 EMD64692.1 - 1.2 9.0 3.2 3.7 7.5 3.2 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5337) ABC_tran PF00005.27 EMD64693.1 - 7.3e-46 156.1 0.1 7.3e-28 97.8 0.1 2.6 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EMD64693.1 - 3e-40 138.6 23.0 2e-24 86.7 10.9 3.7 3 0 0 3 3 3 3 ABC transporter transmembrane region SMC_N PF02463.19 EMD64693.1 - 4.8e-14 52.3 0.7 3.9e-07 29.7 1.2 4.3 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EMD64693.1 - 8.9e-08 32.3 0.8 0.11 12.2 0.0 4.4 3 1 0 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 EMD64693.1 - 1.3e-06 28.8 0.0 0.086 13.1 0.1 3.0 2 1 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EMD64693.1 - 3.7e-06 27.4 2.2 0.033 14.6 0.1 3.4 3 1 0 3 3 2 2 AAA ATPase domain AAA_29 PF13555.6 EMD64693.1 - 2.2e-05 24.1 0.3 0.01 15.6 0.2 3.0 3 0 0 3 3 3 1 P-loop containing region of AAA domain AAA_23 PF13476.6 EMD64693.1 - 3.7e-05 24.3 4.0 0.0022 18.5 0.0 2.9 3 0 0 3 3 2 1 AAA domain AAA_25 PF13481.6 EMD64693.1 - 3.9e-05 23.3 0.1 0.00037 20.1 0.0 2.3 2 0 0 2 2 2 1 AAA domain DUF87 PF01935.17 EMD64693.1 - 0.0002 21.5 0.7 0.00053 20.2 0.7 1.6 1 0 0 1 1 1 1 Helicase HerA, central domain T2SSE PF00437.20 EMD64693.1 - 0.00054 19.1 0.1 0.044 12.8 0.0 2.5 2 0 0 2 2 2 1 Type II/IV secretion system protein MMR_HSR1 PF01926.23 EMD64693.1 - 0.0044 17.1 0.1 1.7 8.8 0.1 2.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EMD64693.1 - 0.0059 16.5 0.0 2.6 7.9 0.0 2.5 2 0 0 2 2 2 1 RsgA GTPase FtsK_SpoIIIE PF01580.18 EMD64693.1 - 0.0066 15.8 0.2 0.029 13.7 0.1 2.0 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_24 PF13479.6 EMD64693.1 - 0.016 15.0 0.6 1.4 8.6 0.0 3.2 3 0 0 3 3 3 0 AAA domain Dynamin_N PF00350.23 EMD64693.1 - 0.017 15.2 0.4 38 4.3 0.0 3.9 4 0 0 4 4 4 0 Dynamin family NACHT PF05729.12 EMD64693.1 - 0.017 15.1 0.2 1.9 8.4 0.1 2.7 2 0 0 2 2 2 0 NACHT domain AAA_33 PF13671.6 EMD64693.1 - 0.025 14.7 0.0 8.6 6.5 0.0 2.8 2 0 0 2 2 2 0 AAA domain TrwB_AAD_bind PF10412.9 EMD64693.1 - 0.035 13.0 0.5 0.14 11.0 0.2 1.9 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain AAA_7 PF12775.7 EMD64693.1 - 0.078 12.5 0.0 1.9 8.0 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region CbiA PF01656.23 EMD64693.1 - 0.085 12.9 0.0 0.56 10.3 0.0 2.2 2 1 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain TsaE PF02367.17 EMD64693.1 - 0.095 12.7 0.0 4.1 7.4 0.0 2.7 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Zeta_toxin PF06414.12 EMD64693.1 - 0.14 11.4 1.5 6 6.1 0.0 2.7 3 0 0 3 3 3 0 Zeta toxin AAA_15 PF13175.6 EMD64693.1 - 0.17 11.5 0.0 25 4.5 0.1 2.4 2 0 0 2 2 2 0 AAA ATPase domain ATPase_2 PF01637.18 EMD64693.1 - 0.19 11.6 0.0 3.6 7.4 0.0 2.8 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea cobW PF02492.19 EMD64693.1 - 0.29 10.7 0.6 15 5.1 0.0 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain ABC_ATPase PF09818.9 EMD64693.1 - 0.3 9.8 1.0 1.6 7.5 0.0 2.3 2 0 0 2 2 2 0 Predicted ATPase of the ABC class T5orf172 PF10544.9 EMD64694.1 - 6.4e-15 55.6 2.0 1.4e-14 54.5 2.0 1.5 1 0 0 1 1 1 1 T5orf172 domain MUG113 PF13455.6 EMD64694.1 - 2.1e-06 28.3 1.5 6.5e-06 26.7 1.3 2.0 2 0 0 2 2 2 1 Meiotically up-regulated gene 113 Tox-URI2 PF15653.6 EMD64694.1 - 0.04 14.2 1.1 0.067 13.5 0.1 1.9 2 1 1 3 3 3 0 URI fold toxin 2 CbtB PF09489.10 EMD64694.1 - 0.069 13.3 0.7 0.13 12.4 0.1 1.7 2 0 0 2 2 2 0 Probable cobalt transporter subunit (CbtB) NMO PF03060.15 EMD64695.1 - 2.4e-58 198.1 1.3 3.2e-58 197.7 1.3 1.1 1 0 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.25 EMD64695.1 - 4.2e-10 39.2 1.0 4.2e-10 39.2 1.0 2.0 2 1 0 2 2 2 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.18 EMD64695.1 - 1.9e-05 23.9 2.0 3.2e-05 23.1 2.0 1.3 1 0 0 1 1 1 1 FMN-dependent dehydrogenase DHO_dh PF01180.21 EMD64695.1 - 0.0021 17.3 0.5 0.0021 17.3 0.5 1.6 2 0 0 2 2 2 1 Dihydroorotate dehydrogenase Glu_synthase PF01645.17 EMD64695.1 - 0.015 14.5 0.2 0.027 13.6 0.2 1.4 2 0 0 2 2 2 0 Conserved region in glutamate synthase Radial_spoke_3 PF06098.11 EMD64695.1 - 0.047 13.0 0.2 0.069 12.4 0.2 1.2 1 0 0 1 1 1 0 Radial spoke protein 3 Pterin_bind PF00809.22 EMD64696.1 - 3.6e-81 272.5 0.2 4.7e-81 272.1 0.2 1.1 1 0 0 1 1 1 1 Pterin binding enzyme HPPK PF01288.20 EMD64696.1 - 5.7e-31 107.3 0.0 1.4e-30 106.0 0.0 1.7 1 0 0 1 1 1 1 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) adh_short PF00106.25 EMD64697.1 - 1.5e-84 282.3 6.9 2.1e-46 157.8 1.0 2.3 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EMD64697.1 - 7.4e-67 225.3 1.2 2.5e-35 122.1 0.0 2.3 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase MaoC_dehydratas PF01575.19 EMD64697.1 - 5.4e-33 113.2 0.0 1.4e-32 111.9 0.0 1.7 1 0 0 1 1 1 1 MaoC like domain KR PF08659.10 EMD64697.1 - 7.6e-30 104.1 2.9 7e-14 52.1 0.1 2.3 2 0 0 2 2 2 2 KR domain Glucodextran_B PF09136.10 EMD64697.1 - 0.022 15.1 0.1 0.086 13.2 0.1 2.0 1 0 0 1 1 1 0 Glucodextranase, domain B Epimerase PF01370.21 EMD64697.1 - 0.17 11.3 1.9 0.4 10.1 0.1 2.4 3 0 0 3 3 3 0 NAD dependent epimerase/dehydratase family Methyltransf_23 PF13489.6 EMD64698.1 - 2.4e-12 47.0 0.0 3e-12 46.7 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMD64698.1 - 5.5e-09 36.6 0.0 1.2e-08 35.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMD64698.1 - 4.3e-08 33.8 0.0 6.8e-08 33.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMD64698.1 - 1.2e-06 29.1 0.0 3.3e-06 27.6 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain CMAS PF02353.20 EMD64698.1 - 0.0021 17.4 0.0 0.0026 17.1 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase FtsJ PF01728.19 EMD64698.1 - 0.023 14.8 0.0 0.41 10.7 0.0 2.1 1 1 1 2 2 2 0 FtsJ-like methyltransferase DUF4675 PF15720.5 EMD64700.1 - 1.3 8.8 6.7 2.5 7.8 6.7 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4675) Lipase_GDSL PF00657.22 EMD64701.1 - 1.3e-08 35.1 0.0 2e-08 34.5 0.0 1.4 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.6 EMD64701.1 - 1.3e-06 28.9 0.1 2.3e-06 28.2 0.1 1.5 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family ORC4_C PF14629.6 EMD64702.1 - 2.2e-55 187.4 0.0 3.2e-55 186.9 0.0 1.3 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 4 C-terminus AAA_16 PF13191.6 EMD64702.1 - 8.3e-16 58.8 0.0 2.7e-15 57.2 0.0 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EMD64702.1 - 3.3e-07 30.7 0.0 6.6e-07 29.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 EMD64702.1 - 3.5e-06 27.5 0.0 8.3e-06 26.3 0.0 1.6 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DUF815 PF05673.13 EMD64702.1 - 2.2e-05 23.8 0.0 3.8e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) NACHT PF05729.12 EMD64702.1 - 3.4e-05 23.8 0.2 0.00071 19.5 0.2 2.4 1 1 0 1 1 1 1 NACHT domain KAP_NTPase PF07693.14 EMD64702.1 - 0.00082 18.7 0.0 0.0013 18.0 0.0 1.2 1 0 0 1 1 1 1 KAP family P-loop domain NB-ARC PF00931.22 EMD64702.1 - 0.0019 17.4 0.1 0.0032 16.7 0.1 1.3 1 0 0 1 1 1 1 NB-ARC domain ATPase_2 PF01637.18 EMD64702.1 - 0.0042 17.0 0.0 0.0084 16.0 0.0 1.4 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea ATP-synt_ab PF00006.25 EMD64702.1 - 0.015 14.9 0.1 0.032 13.9 0.1 1.5 1 1 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_7 PF12775.7 EMD64702.1 - 0.019 14.5 0.0 0.043 13.3 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_30 PF13604.6 EMD64702.1 - 0.021 14.5 0.0 0.058 13.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EMD64702.1 - 0.026 14.3 0.1 0.08 12.7 0.1 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.27 EMD64702.1 - 0.042 14.4 0.0 0.1 13.1 0.0 1.6 1 0 0 1 1 1 0 ABC transporter AAA_14 PF13173.6 EMD64702.1 - 0.065 13.3 0.0 0.14 12.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 EMD64702.1 - 0.067 12.2 0.0 0.11 11.5 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein DUF2791 PF10923.8 EMD64702.1 - 0.084 11.7 0.0 0.12 11.1 0.0 1.2 1 0 0 1 1 1 0 P-loop Domain of unknown function (DUF2791) AAA_19 PF13245.6 EMD64702.1 - 0.097 13.0 0.0 0.22 11.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain TniB PF05621.11 EMD64702.1 - 0.099 12.0 0.1 2.7 7.4 0.1 2.2 1 1 0 1 1 1 0 Bacterial TniB protein cobW PF02492.19 EMD64702.1 - 0.1 12.2 0.1 0.32 10.6 0.1 1.8 1 1 1 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain FtsK_SpoIIIE PF01580.18 EMD64702.1 - 0.12 11.7 0.1 0.23 10.8 0.1 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family TrwB_AAD_bind PF10412.9 EMD64702.1 - 0.14 11.0 0.1 0.3 9.9 0.1 1.4 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain PIF1 PF05970.14 EMD64702.1 - 0.16 11.1 0.1 0.33 10.1 0.0 1.5 2 0 0 2 2 2 0 PIF1-like helicase MFS_1 PF07690.16 EMD64703.1 - 7.9e-17 61.2 50.1 2.1e-11 43.4 19.6 2.4 1 1 0 2 2 2 2 Major Facilitator Superfamily DUF4407 PF14362.6 EMD64703.1 - 7.6 5.8 7.1 12 5.1 0.5 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) MTHFR PF02219.17 EMD64705.1 - 7.9e-113 376.5 0.0 1.1e-112 376.1 0.0 1.2 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase TIM PF00121.18 EMD64706.1 - 7.1e-50 169.6 0.0 8e-50 169.5 0.0 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase Gpr1_Fun34_YaaH PF01184.19 EMD64707.1 - 1.9e-36 125.6 20.6 2.4e-36 125.3 20.6 1.1 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family ABA_GPCR PF12430.8 EMD64707.1 - 0.074 12.8 0.2 0.13 12.0 0.2 1.3 1 0 0 1 1 1 0 Abscisic acid G-protein coupled receptor adh_short PF00106.25 EMD64708.1 - 1.5e-26 93.1 0.2 2e-26 92.6 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD64708.1 - 1.1e-22 80.8 0.2 1.3e-22 80.6 0.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD64708.1 - 3.1e-08 33.7 0.1 3.9e-08 33.4 0.1 1.1 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 EMD64708.1 - 0.00026 20.9 0.0 0.00083 19.3 0.0 1.7 2 0 0 2 2 2 1 NAD(P)H-binding Glyco_hydro_47 PF01532.20 EMD64709.1 - 9e-173 575.4 0.0 2e-172 574.2 0.0 1.5 1 1 0 1 1 1 1 Glycosyl hydrolase family 47 Glyco_hydro_127 PF07944.12 EMD64709.1 - 0.098 11.1 0.1 0.83 8.1 0.0 2.2 2 1 0 2 2 2 0 Beta-L-arabinofuranosidase, GH127 Tim17 PF02466.19 EMD64710.1 - 2.1e-28 98.9 3.3 2.8e-28 98.5 3.3 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Pribosyltran PF00156.27 EMD64711.1 - 2.3e-17 63.0 0.1 4.5e-17 62.0 0.2 1.4 2 0 0 2 2 2 1 Phosphoribosyl transferase domain UPRTase PF14681.6 EMD64711.1 - 0.096 12.1 0.0 0.14 11.6 0.0 1.2 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase eIF3g PF12353.8 EMD64712.1 - 3.2e-43 147.1 6.2 4.9e-43 146.5 6.2 1.3 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit G RRM_1 PF00076.22 EMD64712.1 - 7.1e-19 67.4 0.0 1.4e-18 66.4 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EMD64712.1 - 0.021 14.4 0.0 0.031 13.9 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EMD64712.1 - 0.029 14.2 0.0 0.074 12.9 0.0 1.7 1 0 0 1 1 1 0 Occluded RNA-recognition motif RRM_3 PF08777.11 EMD64712.1 - 0.074 13.1 1.9 0.56 10.3 0.0 2.8 3 0 0 3 3 3 0 RNA binding motif Xpo1 PF08389.12 EMD64714.1 - 7.4e-30 104.0 2.0 3.4e-29 101.8 0.0 3.3 5 0 0 5 5 5 1 Exportin 1-like protein IBN_N PF03810.19 EMD64714.1 - 7e-06 25.9 0.3 3.1e-05 23.8 0.3 2.2 2 0 0 2 2 2 1 Importin-beta N-terminal domain HEAT_EZ PF13513.6 EMD64714.1 - 0.0015 19.0 4.0 0.012 16.1 0.0 4.5 5 0 0 5 5 5 1 HEAT-like repeat RNA_polI_A14 PF08203.11 EMD64714.1 - 0.093 13.5 0.3 0.25 12.1 0.3 1.8 1 0 0 1 1 1 0 Yeast RNA polymerase I subunit RPA14 5-FTHF_cyc-lig PF01812.20 EMD64715.1 - 2.1e-33 115.8 0.0 7.1e-30 104.2 0.0 2.1 2 0 0 2 2 2 2 5-formyltetrahydrofolate cyclo-ligase family Rot1 PF10681.9 EMD64716.1 - 4.9e-92 307.2 0.9 5.7e-92 306.9 0.9 1.0 1 0 0 1 1 1 1 Chaperone for protein-folding within the ER, fungal Fungal_trans_2 PF11951.8 EMD64718.1 - 2.5e-20 72.6 0.7 8.6e-12 44.5 0.5 3.1 3 0 0 3 3 3 3 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD64718.1 - 1.6e-07 31.3 11.5 2.7e-07 30.6 11.5 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CDC73_C PF05179.14 EMD64721.1 - 2.1e-49 167.2 0.0 2.9e-49 166.8 0.0 1.2 1 0 0 1 1 1 1 RNA pol II accessory factor, Cdc73 family, C-terminal Aconitase PF00330.20 EMD64722.1 - 3.1e-162 540.8 0.0 3.8e-162 540.5 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 EMD64722.1 - 7.7e-41 139.5 0.0 1.5e-40 138.6 0.0 1.5 1 0 0 1 1 1 1 Aconitase C-terminal domain Glycos_transf_4 PF00953.21 EMD64723.1 - 9e-34 116.8 12.9 9e-34 116.8 12.9 2.3 3 1 0 3 3 3 1 Glycosyl transferase family 4 Flavi_M PF01004.19 EMD64723.1 - 1.4 8.7 3.8 7.7 6.4 0.2 2.6 2 0 0 2 2 2 0 Flavivirus envelope glycoprotein M WD40 PF00400.32 EMD64724.1 - 3e-16 59.5 6.1 0.00016 22.3 0.2 4.7 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD64724.1 - 6.9e-06 26.3 3.1 0.064 13.6 0.0 4.3 3 1 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain F-box-like PF12937.7 EMD64725.1 - 4.5e-06 26.5 1.2 8.7e-06 25.5 1.2 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EMD64725.1 - 0.016 15.1 0.6 0.016 15.1 0.6 1.8 2 0 0 2 2 2 0 F-box domain ECM11 PF15463.6 EMD64726.1 - 2e-43 148.1 8.8 6e-43 146.6 8.8 1.9 1 0 0 1 1 1 1 Extracellular mutant protein 11 SNAD3 PF18749.1 EMD64726.1 - 0.0027 17.0 2.0 0.0039 16.4 2.0 1.1 1 0 0 1 1 1 1 Secreted Novel AID/APOBEC-like Deaminase 3 CPSase_L_D3 PF02787.19 EMD64726.1 - 0.081 13.3 0.6 0.19 12.1 0.6 1.6 1 0 0 1 1 1 0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain ISG65-75 PF11727.8 EMD64726.1 - 0.45 9.7 3.9 0.73 9.0 3.9 1.2 1 0 0 1 1 1 0 Invariant surface glycoprotein ATP-synt_E PF05680.12 EMD64726.1 - 1.8 8.9 5.9 5.8 7.3 3.2 2.9 2 0 0 2 2 2 0 ATP synthase E chain YjcB PF15940.5 EMD64727.1 - 0.044 14.0 0.2 0.1 12.8 0.2 1.6 1 0 0 1 1 1 0 Family of unknown function Choline_transpo PF04515.12 EMD64729.1 - 1.1e-84 284.5 23.1 1.1e-84 284.5 23.1 2.4 2 1 1 3 3 3 1 Plasma-membrane choline transporter DUF4191 PF13829.6 EMD64729.1 - 3.9 6.8 9.7 2.8 7.2 4.4 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4191) Mannitol_dh_C PF08125.13 EMD64730.1 - 2.1e-43 148.6 0.3 3.2e-43 148.0 0.3 1.3 1 0 0 1 1 1 1 Mannitol dehydrogenase C-terminal domain Mannitol_dh PF01232.23 EMD64730.1 - 2.1e-18 67.0 0.9 2.1e-17 63.7 0.0 2.5 3 0 0 3 3 3 1 Mannitol dehydrogenase Rossmann domain 3HCDH_N PF02737.18 EMD64730.1 - 0.002 18.0 0.0 0.006 16.5 0.0 1.9 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.14 EMD64730.1 - 0.008 15.8 0.4 0.14 11.7 0.1 2.4 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain PAP2_3 PF14378.6 EMD64731.1 - 1.3e-27 96.8 12.0 4e-22 78.8 4.0 2.5 2 0 0 2 2 2 2 PAP2 superfamily Cyclin PF08613.11 EMD64734.1 - 1.2e-25 90.8 0.0 1.7e-25 90.3 0.0 1.2 1 0 0 1 1 1 1 Cyclin SpoVS PF04232.12 EMD64734.1 - 0.14 11.9 0.2 0.68 9.7 0.0 2.0 2 0 0 2 2 2 0 Stage V sporulation protein S (SpoVS) KRE9 PF05390.11 EMD64735.1 - 1.3e-15 58.0 6.9 1.3e-15 58.0 6.9 2.1 3 0 0 3 3 3 1 Yeast cell wall synthesis protein KRE9/KNH1 GPI-anchored PF10342.9 EMD64735.1 - 9.3e-11 42.3 0.0 9.3e-11 42.3 0.0 2.1 3 0 0 3 3 3 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family SspB PF04386.13 EMD64735.1 - 0.11 12.3 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 Stringent starvation protein B Peptidase_M24 PF00557.24 EMD64736.1 - 1.6e-55 188.1 0.2 2.1e-55 187.6 0.2 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 EMD64736.1 - 6.9e-27 93.6 0.0 1.4e-26 92.6 0.0 1.5 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain Glyco_hydro_26 PF02156.15 EMD64737.1 - 4.4e-85 285.9 5.8 6.1e-85 285.4 5.8 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 26 CBM_35 PF16990.5 EMD64737.1 - 1.2e-25 90.1 2.1 1.2e-25 90.1 2.1 1.6 2 0 0 2 2 2 1 Carbohydrate binding module (family 35) DUF5010_C PF18099.1 EMD64737.1 - 0.056 13.6 0.1 0.12 12.5 0.1 1.5 1 0 0 1 1 1 0 DUF5010 C-terminal domain Phage_lysis PF03245.13 EMD64737.1 - 0.064 13.4 0.0 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 Bacteriophage Rz lysis protein NUDIX PF00293.28 EMD64738.1 - 1.4e-21 76.9 0.4 1.7e-21 76.7 0.4 1.1 1 0 0 1 1 1 1 NUDIX domain PhageP22-tail PF09251.10 EMD64738.1 - 0.19 10.1 0.1 0.27 9.6 0.1 1.2 1 0 0 1 1 1 0 Salmonella phage P22 tail-spike BRO1 PF03097.18 EMD64739.1 - 2.4e-134 448.0 4.6 2.4e-134 448.0 4.6 2.0 2 0 0 2 2 2 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.6 EMD64739.1 - 7.3e-81 271.7 13.3 1.5e-80 270.6 13.3 1.6 1 0 0 1 1 1 1 ALIX V-shaped domain binding to HIV DUF416 PF04222.12 EMD64739.1 - 0.0046 16.4 1.5 0.088 12.2 0.1 2.9 3 0 0 3 3 3 1 Protein of unknown function (DUF416) DUF2383 PF09537.10 EMD64739.1 - 0.13 12.6 6.8 2.7 8.4 0.2 5.0 6 0 0 6 6 6 0 Domain of unknown function (DUF2383) DnaJ_C PF01556.18 EMD64740.1 - 6.2e-38 130.2 0.0 8.8e-38 129.7 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EMD64740.1 - 4.1e-22 78.1 1.9 7.8e-22 77.2 1.9 1.5 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 EMD64740.1 - 1.3e-08 35.1 20.7 3e-08 33.9 20.7 1.7 1 0 0 1 1 1 1 DnaJ central domain HypA PF01155.19 EMD64740.1 - 3.4 7.7 8.1 17 5.5 6.0 2.3 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF2318 PF10080.9 EMD64740.1 - 8.7 6.5 6.8 7.9 6.7 0.7 2.4 1 1 1 2 2 2 0 Predicted membrane protein (DUF2318) SAP30_Sin3_bdg PF13867.6 EMD64741.1 - 0.0023 18.2 0.0 0.068 13.5 0.0 2.3 2 0 0 2 2 2 1 Sin3 binding region of histone deacetylase complex subunit SAP30 Adhesin_P1_N PF18652.1 EMD64742.1 - 0.031 14.3 0.1 0.086 12.9 0.1 1.7 1 0 0 1 1 1 0 Adhesin P1 N-terminal domain VEK-30 PF12107.8 EMD64742.1 - 5.6 7.0 6.2 1.5 8.8 1.4 2.3 2 0 0 2 2 2 0 Plasminogen (Pg) ligand in fibrinolytic pathway Glyco_hydro_61 PF03443.14 EMD64743.1 - 4.5e-51 173.7 0.1 5.4e-51 173.5 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 DUF2228 PF10228.9 EMD64744.1 - 0.082 12.6 0.0 0.082 12.6 0.0 1.0 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2228) Glyco_hydro_47 PF01532.20 EMD64745.1 - 3.3e-131 438.4 0.0 3.8e-131 438.1 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Zn_clus PF00172.18 EMD64746.1 - 5.5e-06 26.4 11.6 9e-06 25.7 11.6 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Isochorismatase PF00857.20 EMD64747.1 - 7.6e-32 110.9 0.0 9.3e-32 110.6 0.0 1.1 1 0 0 1 1 1 1 Isochorismatase family Acetyltransf_7 PF13508.7 EMD64748.1 - 1.9e-07 31.4 0.0 4.3e-07 30.3 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EMD64748.1 - 2.4e-06 27.8 0.0 3.6e-06 27.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EMD64748.1 - 0.00014 21.8 0.0 0.0003 20.7 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EMD64748.1 - 0.15 12.1 0.0 0.38 10.8 0.0 1.6 1 1 0 1 1 1 0 FR47-like protein DUF3328 PF11807.8 EMD64749.1 - 7e-25 88.1 0.2 1.1e-24 87.5 0.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) DUF3060 PF11259.8 EMD64750.1 - 0.021 14.5 0.2 0.1 12.3 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3060) Methyltransf_30 PF05430.11 EMD64751.1 - 0.012 15.5 0.0 0.023 14.6 0.0 1.4 1 0 0 1 1 1 0 S-adenosyl-L-methionine-dependent methyltransferase AA_permease_2 PF13520.6 EMD64752.1 - 1.1e-53 182.7 33.9 1.3e-53 182.4 33.9 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EMD64752.1 - 5.4e-35 120.9 28.8 5.4e-35 120.9 28.8 1.6 2 0 0 2 2 2 1 Amino acid permease AgrD PF05931.11 EMD64752.1 - 0.0057 16.7 0.3 0.02 14.9 0.3 2.0 1 0 0 1 1 1 1 Staphylococcal AgrD protein DUF3278 PF11683.8 EMD64752.1 - 0.68 10.0 3.9 0.87 9.7 0.8 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3278) YqeY PF09424.10 EMD64754.1 - 3.4e-25 88.8 2.0 4.1e-25 88.5 2.0 1.1 1 0 0 1 1 1 1 Yqey-like protein GatB_Yqey PF02637.18 EMD64754.1 - 0.0074 16.2 2.2 1.3 8.9 0.4 2.2 1 1 1 2 2 2 2 GatB domain ATP_bind_2 PF03668.15 EMD64754.1 - 0.039 13.2 0.1 0.048 12.9 0.1 1.1 1 0 0 1 1 1 0 P-loop ATPase protein family Nucleoporin_N PF08801.11 EMD64755.1 - 4.6e-86 289.3 0.1 6e-86 288.9 0.1 1.1 1 0 0 1 1 1 1 Nup133 N terminal like Nucleoporin_C PF03177.14 EMD64755.1 - 2.4e-51 175.2 5.0 3.8e-51 174.5 5.0 1.3 1 0 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal CCD48 PF15799.5 EMD64755.1 - 0.069 11.5 0.9 0.15 10.4 0.9 1.5 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 48 Arv1 PF04161.13 EMD64756.1 - 1.7e-70 237.5 0.0 2e-70 237.2 0.0 1.1 1 0 0 1 1 1 1 Arv1-like family ATP_synt_H PF05493.13 EMD64757.1 - 0.0015 19.0 0.2 0.002 18.5 0.2 1.2 1 0 0 1 1 1 1 ATP synthase subunit H 4HBT_3 PF13622.6 EMD64758.1 - 1.5 9.0 5.6 2 8.6 4.9 1.6 1 1 0 1 1 1 0 Thioesterase-like superfamily DUF2781 PF10914.8 EMD64759.1 - 7.7e-38 130.2 8.0 8.8e-38 130.0 8.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2781) Sugar_tr PF00083.24 EMD64760.1 - 7e-116 387.8 25.4 1.3e-115 386.8 25.4 1.4 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD64760.1 - 3.9e-22 78.7 53.5 1.1e-19 70.6 29.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily AAA_16 PF13191.6 EMD64761.1 - 0.13 12.6 0.0 0.25 11.7 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain cobW PF02492.19 EMD64762.1 - 2.8e-46 157.3 0.1 4.2e-46 156.7 0.1 1.3 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.14 EMD64762.1 - 3.3e-06 26.9 0.0 1.1e-05 25.3 0.0 1.8 2 0 0 2 2 2 1 Cobalamin synthesis protein cobW C-terminal domain RsgA_GTPase PF03193.16 EMD64762.1 - 0.00013 21.9 0.1 0.34 10.8 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 EMD64762.1 - 0.006 17.0 0.0 0.012 16.0 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain MMR_HSR1 PF01926.23 EMD64762.1 - 0.0077 16.3 0.0 0.017 15.2 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase MeaB PF03308.16 EMD64762.1 - 0.042 12.8 0.3 1.3 7.9 0.1 2.7 2 1 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB T2SSE PF00437.20 EMD64762.1 - 0.054 12.5 0.1 0.096 11.7 0.1 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_22 PF13401.6 EMD64762.1 - 0.055 13.7 0.2 0.2 11.9 0.0 1.9 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 EMD64762.1 - 0.059 12.6 0.0 0.1 11.8 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin AAA_23 PF13476.6 EMD64762.1 - 0.066 13.7 0.1 0.15 12.5 0.1 1.5 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EMD64762.1 - 0.089 13.3 0.0 0.2 12.2 0.0 1.5 1 0 0 1 1 1 0 ABC transporter AAA_30 PF13604.6 EMD64762.1 - 0.097 12.4 0.4 0.97 9.1 0.0 2.1 2 0 0 2 2 2 0 AAA domain GTP_EFTU PF00009.27 EMD64762.1 - 0.11 12.0 1.4 5.2 6.6 0.1 2.4 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain ATPase_2 PF01637.18 EMD64762.1 - 0.13 12.1 0.0 0.23 11.3 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_18 PF13238.6 EMD64762.1 - 0.14 12.7 0.3 0.42 11.2 0.2 1.7 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EMD64762.1 - 0.18 11.6 0.4 0.53 10.1 0.0 1.9 2 0 0 2 2 2 0 P-loop containing region of AAA domain Mob1_phocein PF03637.17 EMD64763.1 - 5.4e-24 85.1 0.3 7.8e-24 84.6 0.3 1.1 1 0 0 1 1 1 1 Mob1/phocein family Fungal_trans PF04082.18 EMD64764.1 - 6.2e-73 245.1 0.3 9.2e-73 244.5 0.3 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 EMD64764.1 - 0.00018 21.8 15.9 0.00085 19.6 2.0 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMD64764.1 - 0.15 12.5 10.1 0.57 10.7 4.5 2.9 2 0 0 2 2 2 0 Zinc-finger double domain DEAD PF00270.29 EMD64765.1 - 8.7e-27 94.0 0.0 1.6e-26 93.2 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF1998 PF09369.10 EMD64765.1 - 1.6e-19 70.5 2.3 4.3e-19 69.0 2.3 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1998) Helicase_C PF00271.31 EMD64765.1 - 2e-12 47.4 0.0 6.3e-12 45.8 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain EF-hand_7 PF13499.6 EMD64765.1 - 4.5e-09 36.6 1.8 4.7e-05 23.8 0.3 2.7 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EMD64765.1 - 5.7e-08 32.1 1.7 0.0083 16.0 0.0 3.5 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 EMD64765.1 - 5.9e-07 28.6 0.2 0.033 13.8 0.0 3.3 3 0 0 3 3 3 2 EF hand CDT1 PF08839.11 EMD64765.1 - 8.9e-07 29.4 0.1 1.8e-06 28.4 0.1 1.5 1 0 0 1 1 1 1 DNA replication factor CDT1 like EF-hand_9 PF14658.6 EMD64765.1 - 5.5e-06 26.6 0.0 0.039 14.3 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain ResIII PF04851.15 EMD64765.1 - 7.3e-06 26.1 0.0 1.3e-05 25.3 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit EF-hand_5 PF13202.6 EMD64765.1 - 0.18 11.3 3.0 3.8 7.2 0.5 3.0 2 0 0 2 2 2 0 EF hand HIT PF01230.23 EMD64767.1 - 4e-24 85.2 0.6 6e-24 84.6 0.6 1.3 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 EMD64767.1 - 4.1e-05 24.0 0.2 6.6e-05 23.4 0.2 1.3 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding Mac-1 PF09028.10 EMD64767.1 - 0.18 10.8 0.0 0.2 10.7 0.0 1.1 1 0 0 1 1 1 0 Mac 1 Glyco_hydro_61 PF03443.14 EMD64768.1 - 0.17 11.8 0.0 0.29 11.1 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 61 R3H-assoc PF13902.6 EMD64769.1 - 6e-24 84.9 3.8 1.4e-23 83.8 3.8 1.6 1 1 0 1 1 1 1 R3H-associated N-terminal domain Peptidase_M28 PF04389.17 EMD64770.1 - 3.4e-31 108.5 0.0 5.1e-31 107.9 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 EMD64770.1 - 5.8e-07 29.4 0.1 1.7e-06 27.9 0.1 1.8 2 1 0 2 2 2 1 Peptidase family M20/M25/M40 adh_short PF00106.25 EMD64771.1 - 5.6e-34 117.3 0.0 1.7e-26 92.9 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EMD64771.1 - 2.9e-21 76.1 0.0 1.1e-15 57.8 0.0 2.0 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD64771.1 - 9.3e-12 45.2 0.0 1.4e-11 44.6 0.0 1.3 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EMD64771.1 - 0.00016 20.9 0.1 0.00025 20.3 0.1 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 EMD64771.1 - 0.0028 17.1 0.0 0.0037 16.7 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 EMD64771.1 - 0.0043 16.6 0.0 0.0089 15.5 0.0 1.5 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family ATP-grasp_5 PF13549.6 EMD64771.1 - 0.017 14.6 0.1 0.053 13.0 0.0 1.9 2 0 0 2 2 2 0 ATP-grasp domain NAD_binding_10 PF13460.6 EMD64771.1 - 0.025 14.5 0.0 0.043 13.7 0.0 1.5 1 0 0 1 1 1 0 NAD(P)H-binding DUF3053 PF11254.8 EMD64771.1 - 0.062 12.9 0.2 0.2 11.2 0.2 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3053) CoA_binding_2 PF13380.6 EMD64773.1 - 1.2e-27 96.7 0.0 1.5e-27 96.4 0.0 1.1 1 0 0 1 1 1 1 CoA binding domain Aminotran_3 PF00202.21 EMD64774.1 - 3e-104 348.9 0.3 3.7e-104 348.6 0.3 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Neisseria_PilC PF05567.11 EMD64774.1 - 0.026 13.5 0.0 0.12 11.3 0.0 1.9 2 0 0 2 2 2 0 Neisseria PilC beta-propeller domain Aminotran_1_2 PF00155.21 EMD64774.1 - 0.028 13.6 0.0 0.17 11.0 0.0 1.9 2 0 0 2 2 2 0 Aminotransferase class I and II B277 PF17623.2 EMD64775.1 - 0.069 12.2 0.3 0.11 11.6 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function Rhabdo_glycop PF00974.18 EMD64775.1 - 0.18 10.3 2.8 0.27 9.6 2.8 1.2 1 0 0 1 1 1 0 Rhabdovirus spike glycoprotein adh_short PF00106.25 EMD64776.1 - 1.1e-32 113.1 0.0 2.1e-32 112.2 0.0 1.5 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD64776.1 - 3.4e-28 98.8 0.0 5.2e-28 98.2 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD64776.1 - 0.00022 21.2 0.8 0.0047 16.9 0.8 2.3 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 EMD64776.1 - 0.026 14.0 0.0 0.038 13.4 0.0 1.4 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Eno-Rase_NADH_b PF12242.8 EMD64776.1 - 0.094 12.5 0.8 1.8 8.4 0.2 2.3 2 0 0 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase DUF1522 PF07482.11 EMD64777.1 - 0.15 12.4 0.1 0.31 11.4 0.1 1.5 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1522) Prefoldin PF02996.17 EMD64780.1 - 4.8 7.1 9.2 4.8 7.1 0.2 4.1 4 0 0 4 4 4 0 Prefoldin subunit eIF3_N PF09440.10 EMD64780.1 - 5.6 7.4 10.2 1.9 9.0 0.2 3.2 3 0 0 3 3 3 0 eIF3 subunit 6 N terminal domain Lectin_N PF03954.14 EMD64780.1 - 8.8 6.1 10.0 39 4.0 0.2 3.6 3 2 0 3 3 3 0 Hepatic lectin, N-terminal domain Thymidylat_synt PF00303.19 EMD64781.1 - 1.8e-103 345.4 0.0 2e-103 345.2 0.0 1.0 1 0 0 1 1 1 1 Thymidylate synthase PAN_1 PF00024.26 EMD64782.1 - 8.9e-10 38.4 8.3 0.0082 16.1 1.1 3.5 3 0 0 3 3 3 3 PAN domain PAN_4 PF14295.6 EMD64782.1 - 2.4e-08 33.8 15.5 0.00018 21.3 1.0 3.6 3 0 0 3 3 3 3 PAN domain SKG6 PF08693.10 EMD64782.1 - 0.014 14.8 0.5 0.026 13.9 0.5 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain MANEC PF07502.14 EMD64782.1 - 0.37 11.1 7.0 0.15 12.4 0.7 3.0 3 0 0 3 3 3 0 MANEC domain Ldr_toxin PF13940.6 EMD64782.1 - 0.59 10.2 4.1 1.2 9.3 4.1 1.5 1 0 0 1 1 1 0 Toxin Ldr, type I toxin-antitoxin system NOG1_N PF17835.1 EMD64783.1 - 3e-49 167.1 0.1 3e-49 167.1 0.1 2.2 3 0 0 3 3 3 1 NOG1 N-terminal helical domain NOGCT PF08155.11 EMD64783.1 - 1.9e-27 95.0 2.9 5.5e-27 93.5 2.9 1.8 1 0 0 1 1 1 1 NOGCT (NUC087) domain NOG1 PF06858.14 EMD64783.1 - 2.7e-24 84.7 0.3 5.8e-24 83.6 0.3 1.6 1 0 0 1 1 1 1 Nucleolar GTP-binding protein 1 (NOG1) MMR_HSR1 PF01926.23 EMD64783.1 - 1.1e-14 54.5 0.0 2.5e-14 53.3 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EMD64783.1 - 5.1e-07 29.3 0.0 1.3e-06 28.0 0.0 1.7 1 1 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EMD64783.1 - 0.00084 19.3 0.9 0.78 9.6 0.0 3.5 4 0 0 4 4 4 2 RsgA GTPase AAA_18 PF13238.6 EMD64783.1 - 0.088 13.4 0.1 0.66 10.5 0.0 2.5 2 1 0 2 2 2 0 AAA domain AAA_16 PF13191.6 EMD64783.1 - 0.48 10.8 0.0 0.48 10.8 0.0 3.2 3 2 0 3 3 3 0 AAA ATPase domain DUF1989 PF09347.10 EMD64784.1 - 1.3e-24 86.7 0.5 6.7e-23 81.2 0.5 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF1989) ArfGap PF01412.18 EMD64785.1 - 3e-34 117.6 1.1 5.5e-34 116.8 1.1 1.4 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf zf-RanBP PF00641.18 EMD64786.1 - 0.018 14.4 0.8 0.018 14.4 0.8 2.0 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others DZR PF12773.7 EMD64786.1 - 0.065 13.3 4.6 0.18 11.9 0.4 2.3 2 0 0 2 2 2 0 Double zinc ribbon Glyco_hydro_3_C PF01915.22 EMD64788.1 - 7.8e-47 159.9 0.0 1.1e-46 159.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 EMD64788.1 - 1.4e-28 100.2 0.0 3.3e-28 99.0 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 EMD64788.1 - 1.5e-26 92.3 0.2 2.8e-26 91.4 0.2 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain ABC2_membrane PF01061.24 EMD64789.1 - 3.4e-81 271.7 64.8 1.3e-44 152.2 24.3 3.9 4 0 0 4 4 4 2 ABC-2 type transporter ABC_tran PF00005.27 EMD64789.1 - 5e-37 127.5 0.0 9.2e-18 65.1 0.0 2.6 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.12 EMD64789.1 - 1e-34 118.3 4.3 8.6e-32 108.9 0.3 4.1 5 0 0 5 5 3 2 CDR ABC transporter ABC_trans_N PF14510.6 EMD64789.1 - 8.8e-15 55.1 1.0 4e-14 53.0 1.0 2.2 1 1 0 1 1 1 1 ABC-transporter N-terminal AAA_16 PF13191.6 EMD64789.1 - 1e-07 32.5 0.0 0.00017 22.0 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain ABC2_membrane_3 PF12698.7 EMD64789.1 - 7.1e-07 28.7 13.7 7.1e-07 28.7 13.7 4.4 3 2 0 4 4 4 1 ABC-2 family transporter protein AAA_29 PF13555.6 EMD64789.1 - 1.5e-06 27.8 0.8 0.001 18.8 0.2 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_25 PF13481.6 EMD64789.1 - 1.6e-06 27.9 0.1 0.0019 17.8 0.0 2.5 2 0 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 EMD64789.1 - 4.9e-06 26.6 0.0 0.0038 17.1 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase AAA_18 PF13238.6 EMD64789.1 - 9.4e-06 26.2 0.0 0.0036 17.8 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EMD64789.1 - 4.2e-05 23.7 0.0 0.0037 17.4 0.0 3.1 3 0 0 3 3 2 1 AAA domain AAA_21 PF13304.6 EMD64789.1 - 0.0002 21.3 0.0 0.18 11.6 0.0 2.7 3 0 0 3 3 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 EMD64789.1 - 0.00036 20.8 0.0 0.26 11.5 0.0 2.9 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 EMD64789.1 - 0.00082 19.4 0.0 1.5 8.9 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase cobW PF02492.19 EMD64789.1 - 0.0021 17.7 0.5 0.031 13.9 0.1 2.2 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain SMC_N PF02463.19 EMD64789.1 - 0.0028 17.1 0.0 2.5 7.5 0.0 3.2 3 1 0 3 3 3 1 RecF/RecN/SMC N terminal domain AAA_30 PF13604.6 EMD64789.1 - 0.004 16.9 0.1 0.65 9.7 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 EMD64789.1 - 0.0083 15.9 0.1 4.5 6.9 0.2 2.6 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.6 EMD64789.1 - 0.0088 16.3 0.2 0.39 10.9 0.2 2.4 2 0 0 2 2 2 1 AAA domain AAA_23 PF13476.6 EMD64789.1 - 0.0089 16.5 0.2 0.14 12.7 0.0 2.7 3 0 0 3 3 2 1 AAA domain NACHT PF05729.12 EMD64789.1 - 0.011 15.7 0.7 1.3 9.0 0.2 2.5 2 0 0 2 2 2 0 NACHT domain AAA_17 PF13207.6 EMD64789.1 - 0.019 15.4 0.1 1.2 9.6 0.0 3.5 4 0 0 4 4 3 0 AAA domain Ploopntkinase3 PF18751.1 EMD64789.1 - 0.02 14.8 0.1 0.59 10.0 0.0 2.4 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 AAA PF00004.29 EMD64789.1 - 0.084 13.3 0.0 4.4 7.7 0.0 2.9 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) TIP41 PF04176.13 EMD64790.1 - 2.4e-72 242.0 0.4 3e-72 241.7 0.4 1.1 1 0 0 1 1 1 1 TIP41-like family Pkinase PF00069.25 EMD64791.1 - 1.8e-71 240.6 0.0 2.4e-71 240.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD64791.1 - 4.4e-43 147.4 0.0 5.8e-43 147.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMD64791.1 - 7.6e-09 35.3 0.0 6.9e-08 32.1 0.0 2.0 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 EMD64791.1 - 0.00012 21.5 0.1 0.00022 20.6 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EMD64791.1 - 0.00035 19.6 0.0 0.00076 18.5 0.0 1.6 1 1 0 1 1 1 1 Haspin like kinase domain RIO1 PF01163.22 EMD64791.1 - 0.011 15.3 0.3 0.084 12.5 0.0 2.2 2 1 1 3 3 3 0 RIO1 family FTA2 PF13095.6 EMD64791.1 - 0.048 13.3 0.1 0.2 11.3 0.0 1.9 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 EMD64791.1 - 0.049 12.4 0.6 0.084 11.6 0.6 1.4 1 1 0 1 1 1 0 Fungal protein kinase APH PF01636.23 EMD64791.1 - 0.063 13.2 0.0 0.097 12.6 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Peptidase_S8_N PF16361.5 EMD64791.1 - 0.082 13.4 0.1 0.2 12.2 0.1 1.6 1 0 0 1 1 1 0 N-terminal of Subtilase family YrbL-PhoP_reg PF10707.9 EMD64791.1 - 0.09 12.3 0.1 0.25 10.8 0.1 1.8 1 1 0 1 1 1 0 PhoP regulatory network protein YrbL Dicer_dimer PF03368.14 EMD64791.1 - 0.52 10.5 2.2 0.77 9.9 0.3 2.2 2 0 0 2 2 2 0 Dicer dimerisation domain Peptidase_M76 PF09768.9 EMD64792.1 - 1.3e-66 223.6 1.6 1.6e-66 223.3 1.6 1.1 1 0 0 1 1 1 1 Peptidase M76 family SprT-like PF10263.9 EMD64792.1 - 0.028 14.3 1.1 0.048 13.5 0.9 1.8 1 1 1 2 2 2 0 SprT-like family Peptidase_M91 PF14891.6 EMD64792.1 - 0.074 13.4 0.2 0.11 12.8 0.2 1.2 1 0 0 1 1 1 0 Effector protein HNH_5 PF14279.6 EMD64792.1 - 0.2 11.5 1.4 7.5 6.5 0.4 2.5 2 0 0 2 2 2 0 HNH endonuclease zf-BED PF02892.15 EMD64792.1 - 0.59 10.2 3.7 17 5.5 0.1 2.8 2 1 0 2 2 2 0 BED zinc finger AA_kinase PF00696.28 EMD64793.1 - 2.3e-38 132.1 0.9 2.3e-38 132.1 0.9 1.4 2 0 0 2 2 2 1 Amino acid kinase family PUA PF01472.20 EMD64793.1 - 9e-16 57.6 1.3 1.4e-08 34.5 0.1 3.1 3 0 0 3 3 3 2 PUA domain DUF4050 PF13259.6 EMD64793.1 - 0.48 10.7 6.2 0.67 10.3 0.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4050) Glyco_hydro_28 PF00295.17 EMD64794.1 - 4.7e-88 295.4 13.9 5.9e-88 295.1 13.9 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 PHO4 PF01384.20 EMD64796.1 - 1.3e-109 366.4 9.9 1.5e-109 366.1 9.9 1.0 1 0 0 1 1 1 1 Phosphate transporter family Glycophorin_A PF01102.18 EMD64796.1 - 0.059 13.6 0.0 0.17 12.1 0.0 1.7 1 0 0 1 1 1 0 Glycophorin A CotJB PF12652.7 EMD64797.1 - 2 8.7 4.3 44 4.4 0.1 3.0 2 0 0 2 2 2 0 CotJB protein EamA PF00892.20 EMD64798.1 - 3.5e-26 92.0 34.3 1.4e-14 54.4 10.8 2.1 2 0 0 2 2 2 2 EamA-like transporter family UAA PF08449.11 EMD64798.1 - 0.00011 21.6 2.6 0.00083 18.7 0.3 2.5 2 0 0 2 2 2 1 UAA transporter family Trp_oprn_chp PF09534.10 EMD64798.1 - 0.96 9.2 4.4 39 4.0 4.4 2.3 1 1 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) DUF2070 PF09843.9 EMD64798.1 - 6.2 5.0 18.6 1.1 7.5 6.3 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2070) DUF3021 PF11457.8 EMD64798.1 - 7.1 7.0 18.9 1.2 9.4 8.3 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF3021) Pectinesterase PF01095.19 EMD64799.1 - 4e-50 170.2 7.6 5.2e-50 169.8 7.6 1.0 1 0 0 1 1 1 1 Pectinesterase CHORD PF04968.12 EMD64800.1 - 0.0015 19.2 3.7 0.0026 18.4 3.7 1.3 1 0 0 1 1 1 1 CHORD Cytochrom_C_2 PF01322.20 EMD64800.1 - 0.016 16.1 0.0 0.038 14.9 0.0 1.6 1 0 0 1 1 1 0 Cytochrome C' Cut8 PF08559.10 EMD64800.1 - 0.055 13.1 0.3 0.092 12.3 0.3 1.4 1 0 0 1 1 1 0 Cut8, nuclear proteasome tether protein Gram_pos_anchor PF00746.21 EMD64802.1 - 0.037 14.0 2.9 0.098 12.6 2.9 1.8 1 0 0 1 1 1 0 LPXTG cell wall anchor motif Glyco_transf_90 PF05686.12 EMD64803.1 - 4.7e-18 65.3 0.1 4.2e-14 52.3 0.3 2.2 2 0 0 2 2 2 2 Glycosyl transferase family 90 HeLo PF14479.6 EMD64803.1 - 0.029 14.2 0.0 0.13 12.1 0.0 1.9 2 0 0 2 2 2 0 Prion-inhibition and propagation MFS_1 PF07690.16 EMD64804.1 - 7.2e-38 130.4 21.2 2.7e-37 128.5 21.5 1.7 2 0 0 2 2 2 1 Major Facilitator Superfamily MFS_4 PF06779.14 EMD64804.1 - 4.9e-06 26.1 4.9 4.9e-06 26.1 4.9 2.1 2 0 0 2 2 2 2 Uncharacterised MFS-type transporter YbfB DUF3094 PF11293.8 EMD64804.1 - 0.18 11.6 0.7 26 4.6 0.2 3.5 4 0 0 4 4 4 0 Protein of unknown function (DUF3094) OATP PF03137.20 EMD64804.1 - 0.33 9.2 11.5 0.048 12.0 2.1 2.8 2 2 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family GMC_oxred_N PF00732.19 EMD64805.1 - 1.6e-63 214.8 0.0 2.7e-63 214.1 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EMD64805.1 - 6.1e-35 120.8 0.0 1.1e-34 120.0 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase Lycopene_cycl PF05834.12 EMD64805.1 - 9.9e-05 21.5 1.1 0.00019 20.6 1.1 1.4 1 0 0 1 1 1 1 Lycopene cyclase protein FAD_binding_2 PF00890.24 EMD64805.1 - 0.011 14.9 2.4 1.2 8.2 1.5 2.1 2 0 0 2 2 2 0 FAD binding domain Thi4 PF01946.17 EMD64805.1 - 0.012 14.9 0.4 0.012 14.9 0.4 1.7 2 0 0 2 2 2 0 Thi4 family DAO PF01266.24 EMD64805.1 - 0.13 11.8 1.4 0.46 10.0 1.1 2.0 2 0 0 2 2 2 0 FAD dependent oxidoreductase RNA_pol_3_Rpc31 PF11705.8 EMD64806.1 - 0.0066 16.7 11.5 0.014 15.6 11.5 1.6 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 SDA1 PF05285.12 EMD64806.1 - 0.011 15.2 12.4 0.016 14.6 12.4 1.2 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 EMD64806.1 - 0.022 13.0 13.5 0.032 12.4 13.5 1.2 1 0 0 1 1 1 0 Nop14-like family PRANC PF09372.10 EMD64806.1 - 0.098 13.0 0.0 0.26 11.6 0.0 1.7 1 0 0 1 1 1 0 PRANC domain BUD22 PF09073.10 EMD64806.1 - 0.18 11.1 9.7 0.3 10.4 9.7 1.3 1 0 0 1 1 1 0 BUD22 FAM176 PF14851.6 EMD64806.1 - 0.68 9.6 8.6 1.8 8.3 8.6 1.7 1 0 0 1 1 1 0 FAM176 family CDC45 PF02724.14 EMD64806.1 - 0.9 7.8 11.4 1.2 7.3 11.4 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF2076 PF09849.9 EMD64806.1 - 1.1 9.2 7.3 1.8 8.6 7.3 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) DUF2722 PF10846.8 EMD64806.1 - 1.2 8.0 4.8 2 7.3 4.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) DUF4637 PF15470.6 EMD64806.1 - 1.5 8.5 12.8 7.4 6.3 13.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4637) TFB6 PF17110.5 EMD64806.1 - 2.4 7.9 7.4 4.5 7.0 7.4 1.5 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH PPP4R2 PF09184.11 EMD64806.1 - 2.6 7.6 16.2 4.6 6.8 16.2 1.4 1 0 0 1 1 1 0 PPP4R2 SURF2 PF05477.11 EMD64806.1 - 2.6 7.7 9.1 4.4 6.9 9.1 1.4 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) Sporozoite_P67 PF05642.11 EMD64806.1 - 2.9 5.9 8.0 4.7 5.2 8.0 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Adaptin_binding PF10199.9 EMD64806.1 - 4.2 8.0 13.0 7.9 7.1 13.0 1.7 1 1 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 RXT2_N PF08595.11 EMD64806.1 - 5.8 6.9 11.9 12 5.9 11.9 1.5 1 0 0 1 1 1 0 RXT2-like, N-terminal ARF7EP_C PF14949.6 EMD64807.1 - 6.3 7.5 22.4 0.41 11.3 6.4 2.5 2 0 0 2 2 2 0 ARF7 effector protein C-terminus DUF2924 PF11149.8 EMD64809.1 - 0.14 12.6 0.0 0.25 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2924) ZZ PF00569.17 EMD64811.1 - 4.8e-11 42.3 4.6 9.5e-11 41.3 4.6 1.4 1 0 0 1 1 1 1 Zinc finger, ZZ type Myb_DNA-binding PF00249.31 EMD64811.1 - 5.5e-08 32.9 0.0 1.2e-07 31.7 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain SWIRM PF04433.17 EMD64811.1 - 2.3e-07 31.1 0.0 8.7e-07 29.2 0.0 2.0 2 0 0 2 2 2 1 SWIRM domain DUF2054 PF10218.9 EMD64811.1 - 0.016 15.3 0.9 0.037 14.1 0.9 1.6 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2054) Pkinase PF00069.25 EMD64812.1 - 7e-70 235.4 0.0 8.9e-70 235.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD64812.1 - 1.4e-34 119.6 0.0 1.9e-34 119.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 EMD64812.1 - 4.9e-11 43.2 0.3 1.6e-10 41.5 0.3 1.9 1 0 0 1 1 1 1 Protein kinase C terminal domain Haspin_kinase PF12330.8 EMD64812.1 - 1.3e-06 27.6 0.0 2e-06 27.0 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 EMD64812.1 - 0.0031 16.9 0.0 0.005 16.2 0.0 1.4 1 1 0 1 1 1 1 Kinase-like C2 PF00168.30 EMD64812.1 - 0.017 15.4 0.0 0.04 14.2 0.0 1.5 1 0 0 1 1 1 0 C2 domain FTA2 PF13095.6 EMD64812.1 - 0.14 11.8 0.1 0.98 9.0 0.0 2.1 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 PGI PF00342.19 EMD64813.1 - 1.6e-240 798.7 2.8 1.9e-240 798.5 2.8 1.0 1 0 0 1 1 1 1 Phosphoglucose isomerase Ribosomal_S21 PF01165.20 EMD64815.1 - 4.1e-11 42.4 1.8 6.5e-11 41.8 1.8 1.3 1 0 0 1 1 1 1 Ribosomal protein S21 PWI PF01480.17 EMD64816.1 - 1.5e-14 54.1 2.1 1.6e-14 54.0 0.5 1.9 2 0 0 2 2 2 1 PWI domain RRM_1 PF00076.22 EMD64816.1 - 0.0041 16.9 0.0 0.013 15.3 0.0 1.9 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MR_MLE_C PF13378.6 EMD64817.1 - 3.7e-55 186.9 0.0 5.9e-55 186.2 0.0 1.2 1 0 0 1 1 1 1 Enolase C-terminal domain-like MAAL_C PF07476.11 EMD64817.1 - 0.00026 20.2 0.0 0.00046 19.4 0.0 1.4 1 0 0 1 1 1 1 Methylaspartate ammonia-lyase C-terminus MR_MLE_N PF02746.16 EMD64817.1 - 0.00062 20.0 0.0 0.0019 18.4 0.0 1.7 2 0 0 2 2 2 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain Ras PF00071.22 EMD64818.1 - 5.8e-09 35.7 0.0 9.1e-09 35.1 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMD64818.1 - 0.0022 18.2 0.0 0.0033 17.6 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase CFEM PF05730.11 EMD64819.1 - 4.5e-08 33.1 5.3 5.7e-08 32.7 5.3 1.2 1 0 0 1 1 1 1 CFEM domain zf-H2C2_2 PF13465.6 EMD64821.1 - 5.9e-09 36.0 17.6 6.6e-05 23.1 3.7 3.6 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2 PF00096.26 EMD64821.1 - 2.2e-08 34.1 14.2 0.00047 20.4 4.5 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 EMD64821.1 - 0.02 15.2 0.4 0.056 13.7 0.4 1.8 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 EMD64821.1 - 0.042 13.9 1.2 2.5 8.2 0.3 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_4 PF13894.6 EMD64821.1 - 0.054 14.4 3.1 0.054 14.4 3.1 3.1 3 0 0 3 3 3 0 C2H2-type zinc finger FOXP-CC PF16159.5 EMD64821.1 - 0.063 13.9 1.9 0.15 12.7 0.1 2.2 1 1 1 2 2 2 0 FOXP coiled-coil domain DUF3446 PF11928.8 EMD64822.1 - 6.9 7.1 7.9 23 5.4 0.2 3.6 2 1 1 3 3 3 0 Early growth response N-terminal domain ATPase PF06745.13 EMD64824.1 - 4.1e-08 32.9 0.1 9.2e-08 31.7 0.0 1.6 2 0 0 2 2 2 1 KaiC RecA PF00154.21 EMD64824.1 - 6.4e-08 32.4 0.0 3.2e-07 30.1 0.0 1.9 2 0 0 2 2 2 1 recA bacterial DNA recombination protein Rad51 PF08423.11 EMD64824.1 - 3e-07 30.0 0.0 6.7e-07 28.8 0.0 1.5 1 1 0 1 1 1 1 Rad51 AAA_25 PF13481.6 EMD64824.1 - 0.00027 20.6 0.5 0.0012 18.4 0.5 2.1 1 1 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 EMD64824.1 - 0.00088 19.1 0.0 0.0017 18.2 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein CbiA PF01656.23 EMD64824.1 - 0.011 15.8 0.0 0.015 15.4 0.0 1.3 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_24 PF13479.6 EMD64824.1 - 0.013 15.3 0.0 0.021 14.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 EMD64824.1 - 0.022 14.2 0.0 0.046 13.2 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein AAA_31 PF13614.6 EMD64824.1 - 0.12 12.3 0.0 0.22 11.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EMD64824.1 - 0.2 12.2 0.1 0.39 11.2 0.1 1.5 1 0 0 1 1 1 0 ABC transporter AAA_22 PF13401.6 EMD64824.1 - 0.24 11.7 0.3 1.3 9.2 0.3 2.2 2 1 0 2 2 2 0 AAA domain MOSC PF03473.17 EMD64825.1 - 5.6e-26 91.1 0.0 8.8e-26 90.5 0.0 1.3 1 0 0 1 1 1 1 MOSC domain MOSC_N PF03476.16 EMD64825.1 - 1.3e-10 41.2 0.0 2.5e-10 40.3 0.0 1.4 1 0 0 1 1 1 1 MOSC N-terminal beta barrel domain Abhydrolase_6 PF12697.7 EMD64826.1 - 1.3e-12 48.8 0.1 1.5e-12 48.6 0.1 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EMD64826.1 - 4.2e-05 22.9 0.0 0.00046 19.5 0.0 2.5 1 1 0 1 1 1 1 Serine aminopeptidase, S33 DUF676 PF05057.14 EMD64826.1 - 0.0022 17.5 0.0 0.0027 17.3 0.0 1.1 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_5 PF12695.7 EMD64826.1 - 0.0095 15.7 0.1 0.15 11.8 0.1 2.2 1 1 0 1 1 1 1 Alpha/beta hydrolase family PGAP1 PF07819.13 EMD64826.1 - 0.059 13.1 0.1 0.36 10.5 0.1 2.3 2 1 0 2 2 2 0 PGAP1-like protein DUF900 PF05990.12 EMD64826.1 - 0.081 12.4 0.0 0.15 11.5 0.0 1.4 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF900) Thioesterase PF00975.20 EMD64826.1 - 0.14 12.2 0.0 0.25 11.4 0.0 1.3 1 0 0 1 1 1 0 Thioesterase domain HdeA PF06411.11 EMD64826.1 - 0.19 11.9 0.0 0.58 10.4 0.0 1.9 2 0 0 2 2 2 0 HdeA/HdeB family PAN_4 PF14295.6 EMD64827.1 - 0.089 12.7 4.5 2.4 8.1 1.0 2.7 2 0 0 2 2 2 0 PAN domain WD40 PF00400.32 EMD64828.1 - 8.5e-12 45.4 11.3 0.00041 21.1 0.3 5.1 4 1 1 5 5 5 3 WD domain, G-beta repeat Nbas_N PF15492.6 EMD64828.1 - 0.038 13.3 0.4 6.4 6.0 0.0 2.9 2 1 0 3 3 3 0 Neuroblastoma-amplified sequence, N terminal ANAPC4_WD40 PF12894.7 EMD64828.1 - 0.13 12.6 0.1 6.4 7.2 0.0 3.1 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain PAS_3 PF08447.12 EMD64829.1 - 8.5e-12 45.2 0.0 6.2e-08 32.8 0.0 2.3 2 0 0 2 2 2 2 PAS fold PAS_9 PF13426.7 EMD64829.1 - 1.8e-06 28.1 0.0 0.00051 20.3 0.0 2.4 2 0 0 2 2 2 2 PAS domain PAS_11 PF14598.6 EMD64829.1 - 2.3e-05 24.5 0.0 6.6e-05 23.0 0.0 1.7 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 EMD64829.1 - 0.00026 21.0 0.0 0.019 15.0 0.0 2.4 2 0 0 2 2 2 1 PAS fold PAS_4 PF08448.10 EMD64829.1 - 0.0018 18.5 0.0 0.92 9.8 0.0 2.5 2 0 0 2 2 2 2 PAS fold Apt1 PF10351.9 EMD64829.1 - 0.58 8.9 4.5 0.83 8.4 4.5 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain SET PF00856.28 EMD64831.1 - 3.7e-08 33.9 0.1 1.5e-07 32.0 0.0 2.1 2 1 0 2 2 2 1 SET domain PHD PF00628.29 EMD64831.1 - 9e-05 22.3 9.8 0.00017 21.4 9.8 1.5 1 0 0 1 1 1 1 PHD-finger COesterase PF00135.28 EMD64832.1 - 1.7e-18 66.8 2.2 9e-17 61.1 0.5 2.6 1 1 1 2 2 2 2 Carboxylesterase family Lectin_C PF00059.21 EMD64832.1 - 0.0089 16.8 0.5 3.6 8.4 0.1 2.4 1 1 1 2 2 2 2 Lectin C-type domain Ran_BP1 PF00638.18 EMD64834.1 - 4.1e-15 56.1 0.1 7.9e-15 55.2 0.1 1.4 1 0 0 1 1 1 1 RanBP1 domain Yip1 PF04893.17 EMD64835.1 - 4.5e-13 49.3 12.3 6.8e-13 48.7 12.3 1.4 1 0 0 1 1 1 1 Yip1 domain DUF2070 PF09843.9 EMD64835.1 - 9.9 4.3 9.7 12 4.0 9.7 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) GalP_UDP_transf PF01087.22 EMD64836.1 - 2.2e-70 236.9 0.0 2.9e-69 233.2 0.0 2.2 2 0 0 2 2 2 1 Galactose-1-phosphate uridyl transferase, N-terminal domain GalP_UDP_tr_C PF02744.17 EMD64836.1 - 6.5e-59 198.4 0.2 1.5e-58 197.3 0.1 1.6 2 0 0 2 2 2 1 Galactose-1-phosphate uridyl transferase, C-terminal domain HIT PF01230.23 EMD64836.1 - 0.031 15.0 0.0 0.068 13.9 0.0 1.6 1 0 0 1 1 1 0 HIT domain Tyr-DNA_phospho PF06087.12 EMD64837.1 - 1.1e-154 515.4 0.0 1.3e-154 515.2 0.0 1.0 1 0 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase PLDc_2 PF13091.6 EMD64837.1 - 0.0032 17.4 0.1 0.14 12.1 0.0 2.2 2 0 0 2 2 2 1 PLD-like domain C1ORF64 PF15547.6 EMD64837.1 - 0.029 14.8 0.0 0.11 13.0 0.0 2.0 2 0 0 2 2 2 0 Steroid receptor-associated and regulated protein FA_desaturase PF00487.24 EMD64838.1 - 2.8e-18 66.7 13.6 2.8e-18 66.7 13.6 1.6 1 1 1 2 2 2 1 Fatty acid desaturase Cyt-b5 PF00173.28 EMD64838.1 - 1.1e-16 60.7 0.1 2.1e-16 59.8 0.1 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain YndJ PF14158.6 EMD64838.1 - 0.013 14.8 1.2 0.03 13.6 1.2 1.5 2 0 0 2 2 2 0 YndJ-like protein Xan_ur_permease PF00860.20 EMD64839.1 - 4.8e-66 223.1 31.7 8.5e-65 218.9 31.7 2.0 1 1 0 1 1 1 1 Permease family Methyltransf_16 PF10294.9 EMD64840.1 - 9.8e-15 54.7 0.0 8.8e-07 28.8 0.0 2.1 2 0 0 2 2 2 2 Lysine methyltransferase Methyltransf_23 PF13489.6 EMD64840.1 - 0.044 13.6 0.0 0.06 13.2 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain AMP-binding PF00501.28 EMD64841.1 - 1.3e-96 323.8 0.0 1.9e-96 323.3 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EMD64841.1 - 4.4e-05 24.4 0.2 0.00012 23.0 0.2 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain adh_short PF00106.25 EMD64842.1 - 3.3e-39 134.4 0.0 4.4e-39 134.0 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD64842.1 - 3.7e-24 85.6 0.0 4.7e-24 85.2 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD64842.1 - 2.4e-05 24.3 0.1 8.7e-05 22.5 0.1 1.9 1 1 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EMD64842.1 - 0.0079 15.4 0.0 0.01 15.0 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.21 EMD64842.1 - 0.069 12.6 0.0 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Ribosomal_S17_N PF16205.5 EMD64843.1 - 2.9e-33 114.1 0.2 4.7e-33 113.4 0.2 1.3 1 0 0 1 1 1 1 Ribosomal_S17 N-terminal Ribosomal_S17 PF00366.20 EMD64843.1 - 5.9e-25 87.2 0.1 9.9e-25 86.4 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein S17 Erg28 PF03694.13 EMD64844.1 - 1.4e-46 157.4 1.1 1.9e-46 157.0 1.1 1.1 1 0 0 1 1 1 1 Erg28 like protein LCCL PF03815.19 EMD64845.1 - 8.7e-21 73.9 0.3 3.1e-20 72.1 0.0 2.1 2 0 0 2 2 2 1 LCCL domain PAN_1 PF00024.26 EMD64845.1 - 4.8e-09 36.1 3.9 8.1e-05 22.5 0.6 2.4 2 0 0 2 2 2 2 PAN domain PAN_4 PF14295.6 EMD64845.1 - 1e-05 25.4 0.5 1e-05 25.4 0.5 3.1 3 0 0 3 3 3 2 PAN domain PAN_3 PF08277.12 EMD64845.1 - 0.46 10.3 5.3 4.6 7.1 0.5 2.6 2 0 0 2 2 2 0 PAN-like domain p450 PF00067.22 EMD64846.1 - 7.2e-52 176.7 0.0 1.5e-51 175.6 0.0 1.4 1 1 0 1 1 1 1 Cytochrome P450 TAXi_C PF14541.6 EMD64846.1 - 0.12 12.2 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 Xylanase inhibitor C-terminal Trehalase PF01204.18 EMD64847.1 - 6.4e-113 378.3 8.5 1.9e-112 376.7 8.5 1.7 1 1 0 1 1 1 1 Trehalase GDE_C PF06202.14 EMD64847.1 - 3.5e-05 22.9 3.3 0.00024 20.2 3.3 1.9 1 1 0 1 1 1 1 Amylo-alpha-1,6-glucosidase TPR_10 PF13374.6 EMD64847.1 - 0.024 14.5 0.8 0.14 12.0 0.8 2.4 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_12 PF13424.6 EMD64847.1 - 0.11 12.8 1.9 0.24 11.7 0.6 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 EMD64847.1 - 0.14 13.0 0.6 1.2 10.1 0.2 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat Cutinase PF01083.22 EMD64848.1 - 8.9e-49 165.8 0.3 1.1e-48 165.6 0.3 1.1 1 0 0 1 1 1 1 Cutinase VirJ PF06057.11 EMD64848.1 - 0.00072 19.5 0.0 0.00099 19.0 0.0 1.2 1 0 0 1 1 1 1 Bacterial virulence protein (VirJ) PE-PPE PF08237.11 EMD64848.1 - 0.0013 18.4 0.1 0.0019 17.8 0.1 1.2 1 0 0 1 1 1 1 PE-PPE domain DHO_dh PF01180.21 EMD64849.1 - 2.7e-65 220.5 0.2 1.1e-53 182.4 0.0 2.1 2 0 0 2 2 2 2 Dihydroorotate dehydrogenase NMO PF03060.15 EMD64849.1 - 0.012 15.0 0.3 0.029 13.8 0.3 1.6 1 0 0 1 1 1 0 Nitronate monooxygenase INO80_Ies4 PF08193.11 EMD64849.1 - 0.08 12.9 1.7 0.17 11.8 1.7 1.5 1 0 0 1 1 1 0 INO80 complex subunit Ies4 PcrB PF01884.17 EMD64849.1 - 0.11 11.9 2.1 1.6 8.1 0.0 2.7 3 0 0 3 3 3 0 PcrB family Glyco_hydro_28 PF00295.17 EMD64850.1 - 1.5e-48 165.6 12.3 1.8e-48 165.2 12.3 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 AMP-binding PF00501.28 EMD64851.1 - 3.9e-20 71.8 0.0 1.7e-19 69.8 0.0 1.8 1 1 0 1 1 1 1 AMP-binding enzyme U-box PF04564.15 EMD64852.1 - 4.5e-22 78.0 0.0 9.1e-22 77.0 0.0 1.5 1 0 0 1 1 1 1 U-box domain TPR_1 PF00515.28 EMD64852.1 - 1.8e-09 37.0 3.7 0.0003 20.5 0.4 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 EMD64852.1 - 1.9e-08 33.8 0.4 2.8e-07 30.1 0.1 2.4 2 0 0 2 2 2 1 TPR repeat TPR_2 PF07719.17 EMD64852.1 - 8e-08 31.8 0.8 0.0017 18.3 0.1 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 EMD64852.1 - 1.1e-05 25.9 0.4 0.012 16.1 0.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.6 EMD64852.1 - 0.00031 20.9 3.4 0.67 10.5 0.1 3.7 4 0 0 4 4 3 2 Tetratricopeptide repeat CHIP_TPR_N PF18391.1 EMD64852.1 - 0.0011 19.6 10.3 0.0021 18.8 10.3 1.5 1 0 0 1 1 1 1 CHIP N-terminal tetratricopeptide repeat domain TPR_12 PF13424.6 EMD64852.1 - 0.0055 17.0 1.0 4.8 7.6 0.0 2.7 1 1 1 2 2 2 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EMD64852.1 - 0.009 16.2 1.2 0.043 14.0 0.4 2.5 1 1 2 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 SYF2 PF08231.12 EMD64852.1 - 0.0099 16.3 1.0 0.018 15.4 1.0 1.6 1 0 0 1 1 1 1 SYF2 splicing factor zf-NOSIP PF15906.5 EMD64852.1 - 0.012 15.7 0.0 0.069 13.3 0.0 2.2 2 0 0 2 2 2 0 Zinc-finger of nitric oxide synthase-interacting protein TPR_7 PF13176.6 EMD64852.1 - 0.013 15.5 0.1 2.4 8.4 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 EMD64852.1 - 0.017 15.9 0.7 1.5 9.8 0.0 3.7 3 1 2 5 5 5 0 Tetratricopeptide repeat PPR_long PF17177.4 EMD64852.1 - 0.055 12.8 2.6 5.3 6.3 0.0 2.3 1 1 1 2 2 2 0 Pentacotripeptide-repeat region of PRORP TPR_16 PF13432.6 EMD64852.1 - 0.1 13.3 0.1 0.73 10.5 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat Fe-ADH PF00465.19 EMD64854.1 - 3.1e-60 203.9 0.0 4e-60 203.6 0.0 1.0 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 EMD64854.1 - 1.2e-10 41.5 0.0 1.8e-10 41.0 0.0 1.2 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase HSP70 PF00012.20 EMD64855.1 - 8e-267 886.3 16.8 9.2e-267 886.1 16.8 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EMD64855.1 - 6.5e-13 48.2 7.0 2.6e-12 46.2 1.7 2.6 3 0 0 3 3 3 2 MreB/Mbl protein FGGY_C PF02782.16 EMD64855.1 - 0.00037 20.3 0.1 0.0012 18.6 0.0 1.9 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain SMBP PF16785.5 EMD64855.1 - 0.076 13.2 8.1 0.03 14.5 5.0 2.0 2 0 0 2 2 2 0 Small metal-binding protein DUF4363 PF14276.6 EMD64855.1 - 0.27 11.3 8.5 0.61 10.2 8.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4363) DUF2415 PF10313.9 EMD64856.1 - 1.4e-17 63.3 0.0 3.3e-17 62.1 0.0 1.7 1 0 0 1 1 1 1 Uncharacterised protein domain (DUF2415) PQQ_3 PF13570.6 EMD64856.1 - 0.019 15.5 1.9 29 5.3 0.1 4.3 4 0 0 4 4 4 0 PQQ-like domain ANAPC4_WD40 PF12894.7 EMD64856.1 - 0.036 14.4 0.0 2.2 8.7 0.0 3.3 3 1 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Lant_dehydr_C PF14028.6 EMD64856.1 - 4.5 6.7 12.6 0.65 9.5 1.7 2.3 2 0 0 2 2 2 0 Lantibiotic biosynthesis dehydratase C-term Cys_Met_Meta_PP PF01053.20 EMD64857.1 - 4.3e-139 463.3 0.0 5e-139 463.1 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 EMD64857.1 - 1.4e-06 27.8 0.0 2.1e-06 27.2 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 EMD64857.1 - 1.9e-05 24.1 0.0 3.7e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 EMD64857.1 - 7e-05 22.0 0.0 0.00011 21.3 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Met_gamma_lyase PF06838.11 EMD64857.1 - 0.0004 19.0 0.1 0.0018 16.9 0.1 1.8 1 1 0 1 1 1 1 Methionine gamma-lyase Beta_elim_lyase PF01212.21 EMD64857.1 - 0.044 13.1 0.0 0.074 12.3 0.0 1.3 1 0 0 1 1 1 0 Beta-eliminating lyase Bestrophin PF01062.21 EMD64860.1 - 7.3e-35 120.8 0.2 1.2e-34 120.1 0.2 1.2 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel SnoaL PF07366.12 EMD64861.1 - 1e-35 122.3 0.0 1.3e-35 122.0 0.0 1.0 1 0 0 1 1 1 1 SnoaL-like polyketide cyclase SnoaL_2 PF12680.7 EMD64861.1 - 3.6e-19 69.3 0.0 4.2e-19 69.1 0.0 1.0 1 0 0 1 1 1 1 SnoaL-like domain Methyltransf_8 PF05148.15 EMD64862.1 - 1.4e-49 168.9 0.1 7.5e-27 94.6 0.0 3.2 4 0 0 4 4 4 2 Hypothetical methyltransferase Methyltransf_11 PF08241.12 EMD64862.1 - 9.4e-07 29.4 0.0 2.5e-06 28.1 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMD64862.1 - 1.2e-05 25.9 0.0 0.00018 22.1 0.0 2.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMD64862.1 - 0.00042 20.1 0.0 0.33 10.7 0.0 2.4 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 EMD64862.1 - 0.071 13.9 0.4 0.74 10.6 0.0 3.1 2 1 0 2 2 2 0 Methyltransferase domain DUF966 PF06136.13 EMD64862.1 - 1.8 8.2 14.5 3.6 7.2 14.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Methyltransf_32 PF13679.6 EMD64862.1 - 2.9 7.8 0.0 2.9 7.8 0.0 2.9 2 1 0 2 2 2 0 Methyltransferase domain Acetyltransf_1 PF00583.25 EMD64864.1 - 3.6e-11 43.3 0.0 4.9e-11 42.9 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EMD64864.1 - 1.5e-09 37.8 0.0 2.2e-09 37.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EMD64864.1 - 2.8e-07 30.9 0.0 4.3e-07 30.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EMD64864.1 - 3.2e-05 23.8 0.0 6.1e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.6 EMD64864.1 - 0.029 14.5 0.0 0.049 13.8 0.0 1.3 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Acetyltransf_9 PF13527.7 EMD64864.1 - 0.17 11.9 0.0 0.29 11.2 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Glyco_hydro_35 PF01301.19 EMD64865.1 - 1.2e-90 304.4 1.3 1.8e-90 303.8 1.3 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 BetaGal_dom4_5 PF13364.6 EMD64865.1 - 3.1e-58 195.3 1.7 7.4e-34 116.7 0.0 2.6 2 0 0 2 2 2 2 Beta-galactosidase jelly roll domain BetaGal_dom2 PF10435.9 EMD64865.1 - 1.1e-48 165.5 0.9 2.4e-48 164.4 0.9 1.6 1 0 0 1 1 1 1 Beta-galactosidase, domain 2 BetaGal_dom3 PF13363.6 EMD64865.1 - 1e-25 89.1 0.6 4.5e-25 87.0 0.1 2.3 3 0 0 3 3 3 1 Beta-galactosidase, domain 3 Cellulase PF00150.18 EMD64865.1 - 0.0006 19.3 0.0 0.0014 18.1 0.0 1.6 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) CUE PF02845.16 EMD64867.1 - 6.7e-10 38.5 0.0 9.4e-10 38.0 0.0 1.2 1 0 0 1 1 1 1 CUE domain G2BR PF18442.1 EMD64867.1 - 0.079 12.6 5.3 0.16 11.6 5.3 1.5 1 0 0 1 1 1 0 E3 gp78 Ube2g2-binding region (G2BR) DUF5486 PF17588.2 EMD64867.1 - 0.09 12.7 0.6 0.15 12.0 0.6 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5486) DPBB_1 PF03330.18 EMD64868.1 - 6.4e-08 32.8 0.1 1.2e-07 31.9 0.1 1.6 1 1 0 1 1 1 1 Lytic transglycolase Barwin PF00967.17 EMD64868.1 - 0.002 18.0 0.3 0.0032 17.3 0.3 1.2 1 0 0 1 1 1 1 Barwin family SKG6 PF08693.10 EMD64871.1 - 0.011 15.1 0.2 0.022 14.2 0.2 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain IBR PF01485.21 EMD64872.1 - 0.00055 20.1 6.8 0.00055 20.1 6.8 4.5 4 2 1 5 5 5 2 IBR domain, a half RING-finger domain zinc_ribbon_9 PF14369.6 EMD64872.1 - 0.059 13.6 0.0 0.059 13.6 0.0 3.8 5 0 0 5 5 5 0 zinc-ribbon BLOC1_2 PF10046.9 EMD64873.1 - 0.0017 18.6 0.8 0.0073 16.6 0.4 2.0 2 0 0 2 2 2 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF4618 PF15397.6 EMD64873.1 - 0.0099 15.3 0.1 0.032 13.7 0.0 1.8 3 0 0 3 3 3 1 Domain of unknown function (DUF4618) T2SSM PF04612.12 EMD64873.1 - 0.027 14.5 0.2 0.047 13.8 0.2 1.4 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein M Csm1_N PF18504.1 EMD64873.1 - 0.044 14.1 0.4 0.12 12.8 0.4 1.6 1 0 0 1 1 1 0 Csm1 N-terminal domain DUF1853 PF08907.11 EMD64873.1 - 0.055 13.2 0.2 0.092 12.4 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1853) SlyX PF04102.12 EMD64873.1 - 0.096 13.3 2.8 0.12 13.0 0.9 2.1 2 0 0 2 2 2 0 SlyX Spc24 PF08286.11 EMD64873.1 - 0.13 12.5 0.3 0.35 11.1 0.3 1.7 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 CLZ PF16526.5 EMD64873.1 - 0.15 12.5 0.4 1.9 8.9 0.0 2.7 3 0 0 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels TMF_TATA_bd PF12325.8 EMD64873.1 - 0.15 12.3 0.5 0.61 10.3 0.1 2.1 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding NPV_P10 PF05531.12 EMD64873.1 - 0.16 12.4 2.2 1 9.9 0.4 2.3 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein FlxA PF14282.6 EMD64873.1 - 1.3 9.1 5.7 2.1 8.4 1.5 2.6 3 0 0 3 3 3 0 FlxA-like protein DUF4744 PF15918.5 EMD64873.1 - 1.7 9.5 5.2 49 4.9 4.8 2.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4744) PigN PF04987.14 EMD64874.1 - 3.6e-155 517.3 30.0 3.6e-155 517.3 30.0 1.9 2 0 0 2 2 2 1 Phosphatidylinositolglycan class N (PIG-N) Phosphodiest PF01663.22 EMD64874.1 - 1.2e-09 38.2 4.5 1.2e-08 35.0 4.0 2.4 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 EMD64874.1 - 1e-07 31.7 0.1 1.8e-07 30.9 0.1 1.3 1 0 0 1 1 1 1 Sulfatase Metalloenzyme PF01676.18 EMD64874.1 - 0.00039 19.8 0.0 0.00065 19.1 0.0 1.2 1 0 0 1 1 1 1 Metalloenzyme superfamily Baculo_ODV-E27 PF05314.11 EMD64874.1 - 0.033 13.4 0.0 0.067 12.4 0.0 1.5 1 0 0 1 1 1 0 Baculovirus occlusion-derived virus envelope protein EC27 Alk_phosphatase PF00245.20 EMD64874.1 - 0.048 12.6 0.1 0.099 11.6 0.1 1.4 1 0 0 1 1 1 0 Alkaline phosphatase GDI PF00996.18 EMD64875.1 - 3.6e-194 645.3 0.0 4.1e-194 645.1 0.0 1.0 1 0 0 1 1 1 1 GDP dissociation inhibitor NAD_binding_8 PF13450.6 EMD64875.1 - 0.021 15.1 0.0 0.061 13.6 0.0 1.8 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain MRP-L47 PF06984.13 EMD64876.1 - 5.5e-19 68.1 1.2 9.9e-19 67.3 0.5 1.7 2 0 0 2 2 2 1 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) DDE_Tnp_ISL3 PF01610.17 EMD64876.1 - 0.13 12.0 1.6 0.21 11.3 1.6 1.3 1 0 0 1 1 1 0 Transposase bZIP_1 PF00170.21 EMD64877.1 - 2.1e-06 27.7 8.6 3.1e-06 27.2 8.6 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EMD64877.1 - 1.7e-05 24.8 12.1 3.4e-05 23.8 12.1 1.6 1 1 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 EMD64877.1 - 0.00047 20.6 6.0 0.00095 19.6 6.0 1.5 1 0 0 1 1 1 1 bZIP Maf transcription factor DUF3450 PF11932.8 EMD64877.1 - 0.0065 15.8 2.4 0.0065 15.8 2.4 1.4 2 0 0 2 2 2 1 Protein of unknown function (DUF3450) DivIC PF04977.15 EMD64877.1 - 0.0094 15.7 3.0 0.0098 15.6 1.5 1.8 2 0 0 2 2 2 1 Septum formation initiator ZapB PF06005.12 EMD64877.1 - 0.01 16.2 3.1 0.018 15.4 3.1 1.4 1 0 0 1 1 1 0 Cell division protein ZapB DUF745 PF05335.13 EMD64877.1 - 0.02 14.6 1.7 0.02 14.6 1.7 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF745) IFT20 PF14931.6 EMD64877.1 - 0.028 14.6 1.5 0.03 14.5 1.5 1.2 1 0 0 1 1 1 0 Intraflagellar transport complex B, subunit 20 KLRAQ PF10205.9 EMD64877.1 - 0.049 13.9 1.4 0.049 13.9 1.4 1.8 1 1 1 2 2 2 0 Predicted coiled-coil domain-containing protein Tmemb_cc2 PF10267.9 EMD64877.1 - 0.059 12.5 7.0 0.066 12.3 7.0 1.0 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein WD40_alt PF14077.6 EMD64877.1 - 0.06 13.2 1.8 0.26 11.2 1.8 1.9 1 1 1 2 2 2 0 Alternative WD40 repeat motif YabA PF06156.13 EMD64877.1 - 0.062 13.9 1.5 0.083 13.5 0.8 1.6 1 1 1 2 2 2 0 Initiation control protein YabA Macoilin PF09726.9 EMD64877.1 - 0.063 11.8 10.9 0.067 11.7 10.9 1.0 1 0 0 1 1 1 0 Macoilin family HALZ PF02183.18 EMD64877.1 - 0.072 13.3 0.8 0.13 12.5 0.8 1.4 1 0 0 1 1 1 0 Homeobox associated leucine zipper DUF4110 PF13422.6 EMD64877.1 - 0.17 12.0 4.2 0.22 11.6 3.8 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4110) ATG16 PF08614.11 EMD64877.1 - 0.59 10.3 12.1 0.64 10.2 12.1 1.1 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) Takusan PF04822.13 EMD64877.1 - 3.6 7.5 9.1 0.1 12.5 1.0 2.2 2 0 0 2 2 2 0 Takusan Striatin PF08232.12 EMD64877.1 - 4.5 7.8 13.7 0.53 10.9 1.1 2.1 1 1 1 2 2 2 0 Striatin family Phage_holin_2_3 PF16080.5 EMD64878.1 - 0.1 12.4 7.4 2.4 8.0 0.7 3.0 1 1 1 2 2 2 0 Bacteriophage holin family HP1 Peptidase_M3 PF01432.20 EMD64879.1 - 3.9e-160 534.1 0.1 5.1e-160 533.7 0.1 1.1 1 0 0 1 1 1 1 Peptidase family M3 Condensation PF00668.20 EMD64880.1 - 8.3e-68 229.1 0.0 1.1e-29 103.5 0.0 4.0 4 0 0 4 4 4 3 Condensation domain AMP-binding PF00501.28 EMD64880.1 - 4.6e-43 147.4 0.0 7.2e-43 146.7 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme PP-binding PF00550.25 EMD64880.1 - 2.2e-08 34.3 0.0 5.6e-08 33.0 0.0 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site AMP-binding_C PF13193.6 EMD64880.1 - 1.1e-05 26.3 0.0 3.7e-05 24.6 0.0 2.0 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Condensation PF00668.20 EMD64881.1 - 3.8e-12 45.6 0.0 3.9e-12 45.6 0.0 1.0 1 0 0 1 1 1 1 Condensation domain Methyltransf_PK PF05891.12 EMD64881.1 - 0.16 11.4 0.0 0.22 11.0 0.0 1.1 1 0 0 1 1 1 0 AdoMet dependent proline di-methyltransferase Condensation PF00668.20 EMD64882.1 - 3.3e-07 29.3 0.0 4e-07 29.1 0.0 1.2 1 0 0 1 1 1 1 Condensation domain AMP-binding PF00501.28 EMD64883.1 - 7e-85 285.1 0.0 2.5e-84 283.4 0.0 1.7 2 0 0 2 2 2 1 AMP-binding enzyme AMP-binding_C PF13193.6 EMD64883.1 - 1.6e-20 73.8 0.8 8.8e-20 71.5 0.2 2.3 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain ACAS_N PF16177.5 EMD64883.1 - 3.2e-15 55.8 2.7 9.8e-15 54.2 2.5 1.9 2 0 0 2 2 2 1 Acetyl-coenzyme A synthetase N-terminus Peptidase_C14 PF00656.22 EMD64884.1 - 9.2e-21 74.9 0.0 1.3e-20 74.4 0.0 1.2 1 0 0 1 1 1 1 Caspase domain FA_desaturase PF00487.24 EMD64886.1 - 7.4 6.3 7.9 7.4 6.3 7.9 1.0 1 0 0 1 1 1 0 Fatty acid desaturase CHAT PF12770.7 EMD64887.1 - 8.6e-34 117.3 0.1 1.6e-33 116.4 0.1 1.5 1 0 0 1 1 1 1 CHAT domain TPR_10 PF13374.6 EMD64887.1 - 2e-20 72.0 61.0 0.002 17.9 0.3 14.4 14 0 0 14 14 14 9 Tetratricopeptide repeat PyocinActivator PF11112.8 EMD64887.1 - 2.1e-05 24.6 4.1 19 5.5 0.0 7.5 5 3 3 9 9 9 1 Pyocin activator protein PrtN PTP2 PF17022.5 EMD64887.1 - 2.4e-05 24.0 1.7 24 4.4 0.0 7.3 2 2 7 9 9 9 0 Polar tube protein 2 from Microsporidia MMR_HSR1_C PF08438.10 EMD64887.1 - 0.0013 19.3 0.0 1.4e+02 3.1 0.0 7.1 5 1 6 11 11 11 0 GTPase of unknown function C-terminal RPN6_N PF18055.1 EMD64887.1 - 0.043 14.2 5.4 46 4.4 0.1 5.6 4 2 1 5 5 5 0 26S proteasome regulatory subunit RPN6 N-terminal domain PhosphMutase PF10143.9 EMD64887.1 - 0.11 12.4 5.0 37 4.1 0.0 5.6 6 1 1 7 7 7 0 2,3-bisphosphoglycerate-independent phosphoglycerate mutase TPR_9 PF13371.6 EMD64887.1 - 0.16 12.1 11.6 0.35 11.0 0.0 4.6 5 1 0 5 5 5 0 Tetratricopeptide repeat RGS-like PF09128.11 EMD64888.1 - 0.044 13.5 0.0 0.051 13.3 0.0 1.1 1 0 0 1 1 1 0 Regulator of G protein signalling-like domain DUF3847 PF12958.7 EMD64888.1 - 0.79 9.9 6.6 1.2 9.3 6.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3847) Blt1 PF12754.7 EMD64890.1 - 0.14 12.5 0.1 0.21 11.9 0.1 1.3 1 0 0 1 1 1 0 Blt1 N-terminal domain DivIC PF04977.15 EMD64891.1 - 0.0071 16.1 0.0 0.019 14.7 0.0 1.6 1 0 0 1 1 1 1 Septum formation initiator GOLGA2L5 PF15070.6 EMD64891.1 - 0.05 12.3 1.3 0.087 11.5 1.3 1.3 1 0 0 1 1 1 0 Putative golgin subfamily A member 2-like protein 5 Myc_N PF01056.18 EMD64891.1 - 3.7 7.4 9.0 5.8 6.7 9.0 1.4 1 1 0 1 1 1 0 Myc amino-terminal region DDE_3 PF13358.6 EMD64893.1 - 0.00011 22.0 0.2 0.00097 18.9 0.0 2.3 3 0 0 3 3 3 1 DDE superfamily endonuclease ZapB PF06005.12 EMD64893.1 - 0.21 12.0 7.6 0.11 12.9 3.9 2.0 2 0 0 2 2 2 0 Cell division protein ZapB HTH_32 PF13565.6 EMD64894.1 - 0.00017 22.1 0.0 0.00045 20.8 0.0 1.7 1 1 1 2 2 2 1 Homeodomain-like domain HTH_23 PF13384.6 EMD64894.1 - 0.00026 20.7 0.0 0.00054 19.7 0.0 1.5 1 0 0 1 1 1 1 Homeodomain-like domain HTH_Tnp_Tc3_2 PF01498.18 EMD64894.1 - 0.0087 16.3 0.0 0.017 15.3 0.0 1.5 1 0 0 1 1 1 1 Transposase HTH_29 PF13551.6 EMD64894.1 - 0.039 14.0 0.0 0.068 13.2 0.0 1.5 1 1 0 1 1 1 0 Winged helix-turn helix Sigma70_r4_2 PF08281.12 EMD64894.1 - 0.071 12.8 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 Sigma-70, region 4 HTH_Tnp_ISL3 PF13542.6 EMD64894.1 - 0.092 12.2 0.1 0.49 9.8 0.0 2.0 2 0 0 2 2 2 0 Helix-turn-helix domain of transposase family ISL3 Glyco_hydro_31 PF01055.26 EMD64895.1 - 1.7e-158 528.5 2.4 2.6e-158 527.8 2.4 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.5 EMD64895.1 - 2.2e-38 131.0 0.2 5.5e-38 129.7 0.1 1.7 2 0 0 2 2 2 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Gal_mutarotas_2 PF13802.6 EMD64895.1 - 1e-12 48.1 0.7 3.7e-12 46.4 0.7 2.0 1 0 0 1 1 1 1 Galactose mutarotase-like Prp19 PF08606.11 EMD64896.1 - 1.1e-34 118.3 1.8 1.9e-34 117.5 1.8 1.4 1 0 0 1 1 1 1 Prp19/Pso4-like ANAPC4_WD40 PF12894.7 EMD64896.1 - 3e-15 56.3 1.4 0.00025 21.3 0.0 4.6 3 1 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EMD64896.1 - 5.7e-15 55.4 3.3 0.00046 20.9 0.0 5.6 5 0 0 5 5 5 3 WD domain, G-beta repeat WD40_like PF17005.5 EMD64896.1 - 1e-06 28.3 0.0 0.024 14.0 0.0 2.2 1 1 1 2 2 2 2 WD40-like domain Frtz PF11768.8 EMD64896.1 - 0.00014 20.3 0.1 0.013 13.8 0.0 1.3 1 1 1 2 2 2 2 WD repeat-containing and planar cell polarity effector protein Fritz U-box PF04564.15 EMD64896.1 - 0.00042 20.4 0.0 0.001 19.2 0.0 1.6 2 0 0 2 2 1 1 U-box domain PQQ_3 PF13570.6 EMD64896.1 - 0.0054 17.2 2.3 5.9 7.5 0.0 3.8 3 0 0 3 3 3 1 PQQ-like domain Mcl1_mid PF12341.8 EMD64896.1 - 0.0069 15.8 1.0 0.039 13.3 0.2 2.2 1 1 1 2 2 2 2 Minichromosome loss protein, Mcl1, middle region PQQ_2 PF13360.6 EMD64896.1 - 0.02 14.5 2.4 0.21 11.1 1.6 2.5 1 1 0 1 1 1 0 PQQ-like domain Coatomer_WDAD PF04053.14 EMD64896.1 - 0.022 13.8 0.5 0.057 12.4 0.4 1.7 1 1 1 2 2 2 0 Coatomer WD associated region zf-Nse PF11789.8 EMD64896.1 - 0.024 14.4 0.0 0.046 13.5 0.0 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit DUF3450 PF11932.8 EMD64896.1 - 0.033 13.5 0.2 0.062 12.6 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) V_ATPase_I_N PF18670.1 EMD64896.1 - 0.064 13.7 0.1 0.12 12.7 0.1 1.4 1 0 0 1 1 1 0 V-type ATPase subunit I, N-terminal domain PQQ PF01011.21 EMD64896.1 - 0.11 12.4 0.0 0.52 10.3 0.0 2.1 2 0 0 2 2 2 0 PQQ enzyme repeat zf-RING_5 PF14634.6 EMD64897.1 - 0.0032 17.4 5.9 0.0051 16.7 5.9 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EMD64897.1 - 0.0077 16.2 1.4 0.015 15.3 1.4 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 EMD64897.1 - 0.024 15.0 2.1 0.055 13.8 2.1 1.6 1 0 0 1 1 1 0 Ring finger domain zf-C3HC4_2 PF13923.6 EMD64897.1 - 0.12 12.3 0.3 0.12 12.3 0.3 1.7 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMD64897.1 - 0.15 12.0 2.5 0.3 11.0 2.5 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EMD64897.1 - 0.49 10.3 4.6 1.4 8.8 4.6 1.7 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EMD64897.1 - 0.88 9.5 5.6 7 6.6 5.8 2.1 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 FYVE PF01363.21 EMD64897.1 - 1.1 9.5 5.6 2.8 8.2 5.6 1.7 1 1 0 1 1 1 0 FYVE zinc finger PTPLA PF04387.14 EMD64898.1 - 7.4e-55 185.2 9.5 9.9e-55 184.7 9.5 1.2 1 0 0 1 1 1 1 Protein tyrosine phosphatase-like protein, PTPLA CMD PF02627.20 EMD64899.1 - 1.6e-05 24.9 0.0 0.0013 18.7 0.0 2.2 2 0 0 2 2 2 2 Carboxymuconolactone decarboxylase family Methyltransf_34 PF11312.8 EMD64900.1 - 1.3e-113 379.3 0.2 1.6e-113 379.0 0.2 1.0 1 0 0 1 1 1 1 Putative SAM-dependent methyltransferase DUF3309 PF11752.8 EMD64901.1 - 0.0011 19.0 0.7 0.0015 18.5 0.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3309) Glycophorin_A PF01102.18 EMD64901.1 - 0.0049 17.1 0.2 0.007 16.6 0.2 1.4 1 1 0 1 1 1 1 Glycophorin A DUF4690 PF15756.5 EMD64901.1 - 0.035 14.7 0.1 0.054 14.1 0.1 1.4 1 0 0 1 1 1 0 Small Novel Rich in Cartilage DAG1 PF05454.11 EMD64901.1 - 0.057 12.8 0.0 0.078 12.3 0.0 1.2 1 0 0 1 1 1 0 Dystroglycan (Dystrophin-associated glycoprotein 1) ECSCR PF15820.5 EMD64901.1 - 0.087 12.7 0.1 0.11 12.4 0.1 1.2 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator EphA2_TM PF14575.6 EMD64901.1 - 0.11 13.4 0.2 0.13 13.1 0.2 1.3 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Ly49 PF08391.10 EMD64901.1 - 0.11 12.9 0.0 0.35 11.3 0.0 1.7 1 1 0 1 1 1 0 Ly49-like protein, N-terminal region Amnionless PF14828.6 EMD64901.1 - 0.14 11.0 0.0 0.15 10.9 0.0 1.1 1 0 0 1 1 1 0 Amnionless TMEM52 PF14979.6 EMD64901.1 - 0.22 11.4 4.8 2.7 7.9 0.9 2.4 1 1 2 3 3 3 0 Transmembrane 52 MFS_1 PF07690.16 EMD64902.1 - 1.7e-34 119.3 21.6 2.5e-34 118.8 21.6 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Peptidase_M50 PF02163.22 EMD64902.1 - 0.0094 15.2 0.1 0.013 14.8 0.1 1.3 1 0 0 1 1 1 1 Peptidase family M50 DHDPS PF00701.22 EMD64903.1 - 2.3e-37 128.3 0.0 2.7e-37 128.0 0.0 1.1 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family PA PF02225.22 EMD64903.1 - 0.091 12.8 0.0 0.17 12.0 0.0 1.5 1 0 0 1 1 1 0 PA domain Fungal_trans PF04082.18 EMD64904.1 - 4.7e-26 91.4 1.1 7.9e-26 90.7 1.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD64905.1 - 4.6e-08 33.0 10.2 7.5e-08 32.4 10.2 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain LysM PF01476.20 EMD64907.1 - 7.3e-30 102.8 0.7 4.3e-12 45.9 0.0 3.2 3 0 0 3 3 3 3 LysM domain UPF0052 PF01933.18 EMD64908.1 - 3.8e-68 229.9 0.0 4.9e-68 229.5 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein family UPF0052 COMPASS-Shg1 PF05205.12 EMD64910.1 - 3.9e-20 72.5 0.0 3.9e-20 72.5 0.0 2.3 2 0 0 2 2 2 1 COMPASS (Complex proteins associated with Set1p) component shg1 Cytochrom_C550 PF14495.6 EMD64910.1 - 0.091 12.5 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 Cytochrome c-550 domain DOT1 PF08123.13 EMD64911.1 - 1e-55 188.5 0.0 1.4e-55 188.0 0.0 1.2 1 0 0 1 1 1 1 Histone methylation protein DOT1 Frankia_peptide PF14407.6 EMD64911.1 - 0.012 15.5 0.1 0.1 12.6 0.0 2.3 2 0 0 2 2 2 0 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349. Ndc1_Nup PF09531.10 EMD64913.1 - 0.031 13.0 11.7 0.037 12.7 11.7 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup ABC2_membrane_3 PF12698.7 EMD64913.1 - 0.2 10.8 8.8 0.13 11.4 0.9 2.1 2 0 0 2 2 2 0 ABC-2 family transporter protein Suf PF05843.14 EMD64913.1 - 0.2 11.6 11.1 0.29 11.1 11.1 1.4 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) RNase_J_C PF17770.1 EMD64913.1 - 0.25 12.4 1.8 0.62 11.1 1.0 2.1 2 0 0 2 2 2 0 Ribonuclease J C-terminal domain Bul1_N PF04425.12 EMD64913.1 - 1.9 7.1 11.2 3 6.5 11.2 1.3 1 0 0 1 1 1 0 Bul1 N terminus DUF966 PF06136.13 EMD64913.1 - 2.4 7.8 9.3 3.2 7.4 9.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) DUF4551 PF15087.6 EMD64913.1 - 3.1 6.5 10.2 4.2 6.1 10.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) RhoGAP PF00620.27 EMD64914.1 - 4.6e-36 123.9 0.0 7.3e-36 123.3 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain zf-Tim10_DDP PF02953.15 EMD64916.1 - 8.3e-20 70.2 7.1 1.2e-19 69.7 7.1 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger DUF842 PF05811.13 EMD64916.1 - 0.00047 19.9 5.7 0.0015 18.2 5.7 1.7 1 1 0 1 1 1 1 Eukaryotic protein of unknown function (DUF842) Hormone_recep PF00104.30 EMD64916.1 - 0.05 13.2 2.0 0.058 13.0 2.0 1.0 1 0 0 1 1 1 0 Ligand-binding domain of nuclear hormone receptor Pepsin-I3 PF06394.13 EMD64916.1 - 0.21 11.8 2.8 3.2 8.0 1.1 2.2 1 1 1 2 2 2 0 Pepsin inhibitor-3-like repeated domain F-box-like PF12937.7 EMD64917.1 - 0.0018 18.1 0.5 0.0018 18.1 0.5 2.7 3 1 0 3 3 3 1 F-box-like SCNM1_acidic PF15805.5 EMD64917.1 - 0.005 16.5 0.4 0.011 15.4 0.4 1.5 1 0 0 1 1 1 1 Acidic C-terminal region of sodium channel modifier 1 SCNM1 F-box PF00646.33 EMD64917.1 - 0.11 12.5 4.2 1.4 8.9 0.1 3.7 4 0 0 4 4 4 0 F-box domain Asp_Glu_race PF01177.22 EMD64918.1 - 0.00016 21.6 0.0 0.00053 19.9 0.0 1.7 1 1 0 1 1 1 1 Asp/Glu/Hydantoin racemase UPRTase PF14681.6 EMD64920.1 - 4.5e-73 245.1 0.0 5.1e-73 244.9 0.0 1.0 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.27 EMD64920.1 - 6.2e-08 32.3 0.0 9.8e-08 31.7 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain Pribosyl_synth PF14572.6 EMD64920.1 - 0.056 13.5 0.0 0.082 12.9 0.0 1.2 1 0 0 1 1 1 0 Phosphoribosyl synthetase-associated domain CRCB PF02537.15 EMD64921.1 - 1e-37 128.3 13.0 1.2e-22 80.0 9.6 2.6 2 1 0 2 2 2 2 CrcB-like protein, Camphor Resistance (CrcB) Herpes_LMP1 PF05297.11 EMD64921.1 - 2.7 7.1 5.8 0.66 9.1 1.3 2.0 1 1 1 2 2 2 0 Herpesvirus latent membrane protein 1 (LMP1) zf-CHY PF05495.12 EMD64922.1 - 4.5e-11 43.1 12.5 6.6e-11 42.6 12.5 1.3 1 0 0 1 1 1 1 CHY zinc finger zinc_ribbon_12 PF11331.8 EMD64922.1 - 0.003 17.3 1.3 0.0052 16.6 0.0 2.0 2 0 0 2 2 2 1 Probable zinc-ribbon domain IBR PF01485.21 EMD64922.1 - 0.01 16.1 1.8 0.01 16.1 1.8 2.3 2 1 0 2 2 2 1 IBR domain, a half RING-finger domain TIM PF00121.18 EMD64923.1 - 8.3e-90 300.4 0.3 9.4e-90 300.2 0.3 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase CutC PF03932.14 EMD64923.1 - 0.012 15.1 0.0 0.028 13.9 0.0 1.5 1 1 0 1 1 1 0 CutC family L51_S25_CI-B8 PF05047.16 EMD64924.1 - 1.1e-13 50.9 0.0 1.7e-13 50.2 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain U1snRNP70_N PF12220.8 EMD64925.1 - 5.6e-28 97.4 1.3 1e-27 96.6 1.3 1.4 1 0 0 1 1 1 1 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal RRM_1 PF00076.22 EMD64925.1 - 3.4e-16 58.8 0.0 6.3e-16 58.0 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EMD64925.1 - 0.0011 19.1 0.0 0.0018 18.3 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif DUF1308 PF07000.11 EMD64926.1 - 3.7e-07 30.2 0.0 2.4e-06 27.6 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF1308) DUF5614 PF18474.1 EMD64926.1 - 0.058 12.7 0.4 21 4.3 0.0 3.1 3 0 0 3 3 3 0 Family of unknown function (DUF5614) SRP9-21 PF05486.12 EMD64927.1 - 1.4e-32 112.0 1.7 2.3e-32 111.3 1.7 1.4 1 0 0 1 1 1 1 Signal recognition particle 9 kDa protein (SRP9) Aminotran_1_2 PF00155.21 EMD64929.1 - 2.5e-58 198.0 0.0 3.4e-58 197.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Tmemb_18A PF09771.9 EMD64929.1 - 0.21 12.0 0.0 0.42 11.0 0.0 1.5 1 0 0 1 1 1 0 Transmembrane protein 188 Aminotran_5 PF00266.19 EMD64929.1 - 0.23 10.4 0.0 0.33 9.9 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class-V Homeodomain PF00046.29 EMD64931.1 - 1.4e-19 69.7 4.5 2.8e-19 68.7 4.5 1.5 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 EMD64931.1 - 0.0011 18.8 0.8 0.0028 17.5 0.8 1.7 1 0 0 1 1 1 1 Homeobox KN domain MDM10 PF12519.8 EMD64933.1 - 9.1e-148 493.0 5.6 2.3e-130 435.6 0.8 2.0 1 1 1 2 2 2 2 Mitochondrial distribution and morphology protein 10 Porin_3 PF01459.22 EMD64933.1 - 6.4e-08 32.4 0.0 0.0072 15.8 0.0 2.6 2 1 0 2 2 2 2 Eukaryotic porin RL10P_insert PF17777.1 EMD64934.1 - 7.9e-24 83.5 0.0 1.5e-23 82.6 0.0 1.5 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_L10 PF00466.20 EMD64934.1 - 5.8e-20 71.3 0.1 8.9e-20 70.7 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L10 Antimicrobial10 PF08105.11 EMD64935.1 - 0.077 13.1 0.0 0.18 11.9 0.0 1.7 1 0 0 1 1 1 0 Metchnikowin family SOG2 PF10428.9 EMD64935.1 - 1.1 8.4 25.6 1.2 8.3 25.6 1.0 1 0 0 1 1 1 0 RAM signalling pathway protein MFS_1 PF07690.16 EMD64936.1 - 1.5e-35 122.8 23.6 1.5e-35 122.8 23.6 1.7 1 1 0 1 1 1 1 Major Facilitator Superfamily A_deaminase PF00962.22 EMD64937.1 - 2.7e-30 105.8 0.0 3.3e-30 105.5 0.0 1.1 1 0 0 1 1 1 1 Adenosine/AMP deaminase WD40 PF00400.32 EMD64938.1 - 3.8e-38 128.8 20.7 1.5e-05 25.7 0.1 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD64938.1 - 1.7e-16 60.3 0.0 0.00034 20.8 0.1 5.1 1 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EMD64938.1 - 8e-05 22.6 0.0 0.038 13.9 0.0 2.7 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 EMD64938.1 - 0.0013 18.1 0.0 0.034 13.5 0.0 2.7 2 1 1 3 3 3 1 WD40-like domain Cytochrom_D1 PF02239.16 EMD64938.1 - 0.086 11.3 0.0 0.17 10.4 0.0 1.5 2 0 0 2 2 2 0 Cytochrome D1 heme domain Phosducin PF02114.16 EMD64939.1 - 2.2e-14 53.0 0.0 3.3e-11 42.6 0.0 2.2 2 0 0 2 2 2 2 Phosducin zf-MYND PF01753.18 EMD64941.1 - 3e-07 30.4 19.8 6.4e-07 29.4 19.8 1.6 1 0 0 1 1 1 1 MYND finger zf-TAZ PF02135.16 EMD64941.1 - 0.57 10.7 8.8 0.98 9.9 8.8 1.3 1 0 0 1 1 1 0 TAZ zinc finger CorA PF01544.18 EMD64942.1 - 1.1e-22 80.7 16.5 3.4e-19 69.3 13.0 3.0 2 1 0 2 2 2 2 CorA-like Mg2+ transporter protein EMP70 PF02990.16 EMD64942.1 - 0.16 10.6 1.2 0.24 10.0 1.2 1.1 1 0 0 1 1 1 0 Endomembrane protein 70 GDA1_CD39 PF01150.17 EMD64943.1 - 1e-95 320.9 0.0 1.3e-95 320.6 0.0 1.0 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family Ppx-GppA PF02541.16 EMD64943.1 - 0.019 14.4 0.0 0.031 13.7 0.0 1.2 1 0 0 1 1 1 0 Ppx/GppA phosphatase family Pax7 PF12360.8 EMD64943.1 - 2.5 8.4 4.4 1.1 9.5 0.1 2.5 3 0 0 3 3 3 0 Paired box protein 7 p450 PF00067.22 EMD64945.1 - 1.9e-67 228.1 0.0 2.2e-67 227.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Glyco_hydro_79C PF16862.5 EMD64946.1 - 3.2e-25 89.0 0.0 6.9e-25 87.9 0.0 1.6 1 0 0 1 1 1 1 Glycosyl hydrolase family 79 C-terminal beta domain PUL PF08324.11 EMD64947.1 - 3e-46 157.9 0.5 4.2e-46 157.4 0.5 1.1 1 0 0 1 1 1 1 PUL domain Peptidase_C97 PF05903.14 EMD64947.1 - 5.3e-40 136.7 0.0 9.5e-40 135.9 0.0 1.4 1 0 0 1 1 1 1 PPPDE putative peptidase domain Thioredoxin PF00085.20 EMD64947.1 - 1.2e-08 34.9 0.0 2.4e-08 33.9 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin TraF PF13728.6 EMD64947.1 - 0.005 16.7 0.0 0.0094 15.8 0.0 1.4 1 0 0 1 1 1 1 F plasmid transfer operon protein Thioredoxin_2 PF13098.6 EMD64947.1 - 0.014 15.9 0.3 0.062 13.8 0.3 2.1 1 1 0 1 1 1 0 Thioredoxin-like domain RNase_H PF00075.24 EMD64948.1 - 1.7e-18 67.1 0.5 1.8e-17 63.9 0.0 2.1 2 0 0 2 2 2 1 RNase H Glycos_transf_2 PF00535.26 EMD64948.1 - 0.17 11.7 1.2 1.9 8.3 0.6 2.1 2 0 0 2 2 2 0 Glycosyl transferase family 2 CTD_bind PF04818.13 EMD64949.1 - 0.061 14.1 0.0 16 6.4 0.0 2.9 3 0 0 3 3 3 0 RNA polymerase II-binding domain. Mac-1 PF09028.10 EMD64949.1 - 0.085 11.9 0.0 11 5.0 0.0 2.1 1 1 1 2 2 2 0 Mac 1 MRP-S23 PF10484.9 EMD64949.1 - 0.14 12.4 0.0 0.25 11.6 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal protein S23 Zn_clus PF00172.18 EMD64951.1 - 2.3e-08 34.0 9.9 5.6e-08 32.8 9.9 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EMD64951.1 - 0.00019 20.4 0.1 0.00042 19.2 0.1 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain Nup192 PF11894.8 EMD64952.1 - 0 1470.1 0.2 0 1470.0 0.2 1.0 1 0 0 1 1 1 1 Nuclear pore complex scaffold, nucleoporins 186/192/205 PI3_PI4_kinase PF00454.27 EMD64953.1 - 5.9e-51 173.7 0.4 3.2e-50 171.3 0.0 2.4 3 0 0 3 3 3 1 Phosphatidylinositol 3- and 4-kinase TAN PF11640.8 EMD64953.1 - 3.1e-36 124.8 3.0 3.1e-35 121.5 0.1 3.7 5 0 0 5 5 5 1 Telomere-length maintenance and DNA damage repair FATC PF02260.20 EMD64953.1 - 2.3e-11 43.3 0.1 4.7e-10 39.1 0.0 2.6 2 0 0 2 2 2 1 FATC domain Mad3_BUB1_I PF08311.12 EMD64953.1 - 0.035 14.1 0.3 0.23 11.4 0.3 2.5 1 0 0 1 1 1 0 Mad3/BUB1 homology region 1 Nucleo_P87 PF07267.11 EMD64955.1 - 0.51 9.1 13.2 0.71 8.7 8.8 2.0 2 0 0 2 2 2 0 Nucleopolyhedrovirus capsid protein P87 MAP65_ASE1 PF03999.12 EMD64956.1 - 5.7e-75 253.2 11.9 2.3e-74 251.2 7.9 2.1 1 1 1 2 2 2 2 Microtubule associated protein (MAP65/ASE1 family) YqcI_YcgG PF08892.11 EMD64956.1 - 0.018 14.9 0.5 0.073 12.9 0.2 2.2 1 1 1 2 2 2 0 YqcI/YcgG family FAP206 PF12018.8 EMD64956.1 - 0.033 13.7 0.8 0.064 12.8 0.8 1.5 1 0 0 1 1 1 0 Domain of unknown function Takusan PF04822.13 EMD64956.1 - 0.093 12.6 5.7 0.044 13.7 1.1 2.7 2 0 0 2 2 2 0 Takusan Baculo_PEP_C PF04513.12 EMD64956.1 - 0.29 11.2 2.0 2.6 8.1 0.2 3.2 4 0 0 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4407 PF14362.6 EMD64956.1 - 2 7.7 9.8 0.43 9.9 0.3 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Syntaxin_2 PF14523.6 EMD64956.1 - 2.5 8.5 10.4 1.1 9.6 2.9 3.5 2 1 1 3 3 3 0 Syntaxin-like protein Spectrin PF00435.21 EMD64956.1 - 3.3 8.2 18.9 0.52 10.8 0.9 4.9 4 1 0 4 4 4 0 Spectrin repeat SKA2 PF16740.5 EMD64956.1 - 3.6 7.4 14.0 0.18 11.6 0.5 4.2 4 2 2 6 6 6 0 Spindle and kinetochore-associated protein 2 RmuC PF02646.16 EMD64956.1 - 9.8 5.2 8.2 19 4.3 1.4 3.0 3 0 0 3 3 3 0 RmuC family Bac_rhamnosid6H PF17389.2 EMD64957.1 - 1.5e-12 47.4 2.2 2e-12 47.0 1.2 1.7 2 0 0 2 2 2 1 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain Trehalase PF01204.18 EMD64957.1 - 8.2e-06 24.9 1.1 1.2e-05 24.4 1.1 1.1 1 0 0 1 1 1 1 Trehalase Bac_rhamnosid_C PF17390.2 EMD64957.1 - 5.5e-05 22.9 0.0 0.00015 21.5 0.0 1.7 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase C-terminal domain CytB6-F_Fe-S PF08802.10 EMD64957.1 - 0.04 13.9 0.8 0.14 12.2 0.8 2.0 1 0 0 1 1 1 0 Cytochrome B6-F complex Fe-S subunit Vps16_N PF04841.13 EMD64958.1 - 7e-97 324.8 0.0 9.4e-97 324.3 0.0 1.2 1 0 0 1 1 1 1 Vps16, N-terminal region Vps16_C PF04840.12 EMD64958.1 - 6.2e-83 278.5 0.2 1.1e-82 277.7 0.2 1.3 1 1 0 1 1 1 1 Vps16, C-terminal region ANAPC4_WD40 PF12894.7 EMD64958.1 - 0.00016 21.9 0.0 0.11 12.8 0.0 2.7 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain HTH_23 PF13384.6 EMD64959.1 - 0.00087 19.0 0.0 0.0013 18.4 0.0 1.3 1 0 0 1 1 1 1 Homeodomain-like domain Sigma70_r4_2 PF08281.12 EMD64959.1 - 0.0031 17.1 0.0 0.0049 16.5 0.0 1.4 1 0 0 1 1 1 1 Sigma-70, region 4 Sigma70_r4 PF04545.16 EMD64959.1 - 0.0061 16.1 0.0 0.01 15.4 0.0 1.4 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_24 PF13412.6 EMD64959.1 - 0.054 13.1 0.0 0.24 11.0 0.0 1.8 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding Kinesin PF00225.23 EMD64960.1 - 3.7e-112 374.5 0.0 5.3e-112 374.0 0.0 1.2 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EMD64960.1 - 4.7e-26 91.5 0.0 1.1e-25 90.3 0.0 1.6 1 0 0 1 1 1 1 Microtubule binding Spc7 PF08317.11 EMD64960.1 - 0.011 14.7 6.2 0.019 13.9 6.2 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein bZIP_1 PF00170.21 EMD64960.1 - 0.017 15.2 3.3 0.024 14.7 0.4 2.5 1 1 1 2 2 2 0 bZIP transcription factor DUF87 PF01935.17 EMD64960.1 - 0.036 14.2 2.6 0.43 10.6 0.1 2.6 2 0 0 2 2 2 0 Helicase HerA, central domain Shugoshin_N PF07558.11 EMD64960.1 - 0.058 13.3 0.1 0.17 11.8 0.1 1.8 1 0 0 1 1 1 0 Shugoshin N-terminal coiled-coil region YabA PF06156.13 EMD64960.1 - 0.08 13.6 6.7 0.33 11.6 0.1 3.6 3 1 1 4 4 3 0 Initiation control protein YabA GAS PF13851.6 EMD64960.1 - 0.083 12.2 5.5 0.15 11.4 5.5 1.3 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding SnAC PF14619.6 EMD64960.1 - 0.42 11.2 2.9 23 5.7 0.0 3.0 2 0 0 2 2 2 0 Snf2-ATP coupling, chromatin remodelling complex FAM184 PF15665.5 EMD64960.1 - 0.51 10.1 9.0 0.071 12.9 4.5 1.8 2 0 0 2 2 2 0 Family with sequence similarity 184, A and B DivIC PF04977.15 EMD64960.1 - 2.1 8.2 7.0 2.9 7.7 0.1 3.2 2 1 0 3 3 3 0 Septum formation initiator TMF_DNA_bd PF12329.8 EMD64960.1 - 2.6 8.1 5.7 1.8 8.6 0.3 2.7 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding SpoU_methylase PF00588.19 EMD64961.1 - 3.9e-22 79.0 0.0 7.6e-22 78.0 0.0 1.5 1 0 0 1 1 1 1 SpoU rRNA Methylase family BTB PF00651.31 EMD64962.1 - 1.8e-08 34.6 0.0 3.8e-08 33.5 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain DUF3342 PF11822.8 EMD64962.1 - 0.022 14.9 0.0 0.067 13.4 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3342) cEGF PF12662.7 EMD64963.1 - 0.03 14.3 2.7 0.03 14.3 2.7 3.0 3 0 0 3 3 3 0 Complement Clr-like EGF-like Ank_2 PF12796.7 EMD64964.1 - 3.3e-18 66.1 1.0 4.4e-10 40.0 0.0 3.0 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EMD64964.1 - 3.7e-12 46.2 2.5 8e-05 22.8 0.0 4.1 2 1 2 4 4 4 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 EMD64964.1 - 6.4e-11 42.6 2.6 4e-07 30.5 0.1 3.1 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 EMD64964.1 - 1.2e-10 41.3 11.8 5.2e-07 29.8 0.0 5.2 5 0 0 5 5 5 2 Ankyrin repeat Ank_3 PF13606.6 EMD64964.1 - 1e-09 37.8 1.7 0.0024 18.2 0.0 4.5 4 0 0 4 4 4 2 Ankyrin repeat AAA_22 PF13401.6 EMD64964.1 - 1.4e-06 28.7 0.1 3.6e-05 24.1 0.0 2.5 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 EMD64964.1 - 4e-05 23.6 0.0 9.1e-05 22.4 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA PF00004.29 EMD64964.1 - 0.0056 17.1 0.0 0.021 15.2 0.0 2.0 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) SesA PF17107.5 EMD64964.1 - 0.091 13.0 0.3 0.38 11.0 0.1 2.1 2 0 0 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases RPN2_C PF18004.1 EMD64965.1 - 0.32 10.9 3.2 0.47 10.4 3.2 1.3 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain DNA_pol_phi PF04931.13 EMD64965.1 - 5.2 5.0 7.4 6.5 4.7 7.4 1.1 1 0 0 1 1 1 0 DNA polymerase phi Glyco_hydro_61 PF03443.14 EMD64966.1 - 5e-40 137.7 0.0 7e-40 137.2 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 S1 PF00575.23 EMD64967.1 - 2.5e-60 200.8 32.7 4.5e-11 42.9 2.9 13.0 13 0 0 13 13 13 11 S1 RNA binding domain RNase_II_C_S1 PF18614.1 EMD64967.1 - 4.5e-06 26.5 10.7 0.4 10.7 0.1 7.1 8 0 0 8 8 8 2 RNase II-type exonuclease C-terminal S1 domain TPR_19 PF14559.6 EMD64967.1 - 0.0001 22.7 1.4 0.26 11.8 0.1 2.9 3 0 0 3 3 3 2 Tetratricopeptide repeat Suf PF05843.14 EMD64967.1 - 0.0002 21.5 0.0 0.0089 16.0 0.0 4.5 3 2 2 5 5 4 2 Suppressor of forked protein (Suf) PPR PF01535.20 EMD64967.1 - 0.00024 21.1 1.4 0.054 13.8 0.2 3.5 3 0 0 3 3 3 1 PPR repeat TPR_14 PF13428.6 EMD64967.1 - 0.0017 19.0 0.9 7.9 7.6 0.1 4.5 3 1 1 4 4 4 1 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 EMD64967.1 - 0.037 14.0 0.1 0.29 11.1 0.0 2.2 2 0 0 2 2 2 0 Mad3/BUB1 homology region 1 PPR_2 PF13041.6 EMD64967.1 - 0.046 13.9 1.1 0.45 10.8 0.1 2.7 2 0 0 2 2 2 0 PPR repeat family TPR_15 PF13429.6 EMD64967.1 - 0.057 12.6 1.0 0.46 9.7 0.6 2.3 2 1 1 3 3 3 0 Tetratricopeptide repeat S1_2 PF13509.6 EMD64967.1 - 0.098 12.7 1.0 3 8.0 0.0 3.9 4 0 0 4 4 4 0 S1 domain EXOSC1 PF10447.9 EMD64967.1 - 7.1 7.3 10.4 34 5.1 0.7 5.0 4 1 1 5 5 5 0 Exosome component EXOSC1/CSL4 WD40 PF00400.32 EMD64968.1 - 1.4e-15 57.4 10.1 0.0095 16.8 0.0 6.8 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD64968.1 - 9.4e-10 38.7 0.3 9.1e-05 22.7 0.0 4.8 4 1 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EMD64968.1 - 0.00011 21.7 0.1 0.014 14.7 0.0 2.4 2 1 1 3 3 3 2 WD40-like domain Glyco_hydro_61 PF03443.14 EMD64969.1 - 1.8e-56 191.3 0.6 2.2e-56 191.1 0.6 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 Transp_cyt_pur PF02133.15 EMD64970.1 - 4.6e-143 477.2 34.6 5.4e-143 476.9 34.6 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin TRAP-delta PF05404.12 EMD64971.1 - 0.11 12.0 1.3 0.2 11.2 0.4 1.8 1 1 1 2 2 2 0 Translocon-associated protein, delta subunit precursor (TRAP-delta) DUF3970 PF13113.6 EMD64971.1 - 0.15 12.3 0.1 0.35 11.1 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3970) Rick_17kDa_Anti PF05433.15 EMD64972.1 - 0.0014 18.4 15.3 0.0042 16.9 15.0 1.8 1 1 1 2 2 2 2 Glycine zipper 2TM domain PAPA-1 PF04795.12 EMD64973.1 - 0.0028 18.4 0.5 0.0088 16.8 0.1 2.0 2 0 0 2 2 2 1 PAPA-1-like conserved region TMEM154 PF15102.6 EMD64973.1 - 0.035 14.0 1.3 0.087 12.7 0.2 2.3 2 0 0 2 2 2 0 TMEM154 protein family Syndecan PF01034.20 EMD64973.1 - 0.05 13.5 0.6 0.094 12.6 0.6 1.3 1 0 0 1 1 1 0 Syndecan domain CoatB PF10389.9 EMD64973.1 - 0.093 12.6 2.8 0.18 11.7 2.8 1.4 1 0 0 1 1 1 0 Bacteriophage coat protein B Herpes_gE PF02480.16 EMD64973.1 - 0.17 10.6 1.3 3.5 6.3 0.0 2.2 2 0 0 2 2 2 0 Alphaherpesvirus glycoprotein E DCP2 PF05026.13 EMD64974.1 - 1.1e-30 105.8 1.5 2.1e-30 104.9 1.5 1.5 1 0 0 1 1 1 1 Dcp2, box A domain NUDIX PF00293.28 EMD64974.1 - 5.5e-16 58.8 0.1 9.8e-16 58.0 0.1 1.4 1 0 0 1 1 1 1 NUDIX domain DUF4112 PF13430.6 EMD64975.1 - 8.9e-29 99.8 0.6 1.2e-28 99.5 0.6 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4112) PAP2_3 PF14378.6 EMD64977.1 - 1.5e-32 112.8 19.7 2.9e-16 59.7 0.1 3.3 2 1 1 3 3 3 3 PAP2 superfamily PAP2 PF01569.21 EMD64977.1 - 0.02 14.6 1.8 0.02 14.6 1.8 2.6 2 1 1 3 3 3 0 PAP2 superfamily CDC14 PF08045.11 EMD64978.1 - 2.6e-115 384.4 0.1 3.2e-115 384.1 0.1 1.1 1 0 0 1 1 1 1 Cell division control protein 14, SIN component Sod_Cu PF00080.20 EMD64978.1 - 8.4e-10 39.0 0.1 1.6e-09 38.1 0.1 1.4 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) Dak1 PF02733.17 EMD64979.1 - 1.4e-96 323.1 0.1 1.9e-96 322.6 0.1 1.2 1 0 0 1 1 1 1 Dak1 domain Dak2 PF02734.17 EMD64979.1 - 2.5e-36 125.2 0.8 4.2e-36 124.4 0.8 1.4 1 0 0 1 1 1 1 DAK2 domain PIG-F PF06699.11 EMD64980.1 - 3.9e-68 229.1 4.8 4.7e-68 228.9 4.8 1.0 1 0 0 1 1 1 1 GPI biosynthesis protein family Pig-F Gly-zipper_YMGG PF13441.6 EMD64980.1 - 0.011 15.4 4.7 0.16 11.8 0.2 2.3 2 0 0 2 2 2 0 YMGG-like Gly-zipper PHO4 PF01384.20 EMD64980.1 - 0.17 10.9 5.2 0.32 10.0 5.0 1.6 1 1 0 1 1 1 0 Phosphate transporter family Bacteriocin_IIc PF10439.9 EMD64980.1 - 0.26 11.4 3.1 15 5.8 0.4 2.6 2 0 0 2 2 2 0 Bacteriocin class II with double-glycine leader peptide Gly-zipper_Omp PF13488.6 EMD64980.1 - 0.71 9.9 8.2 7.2 6.7 8.2 2.2 1 1 0 1 1 1 0 Glycine zipper Gly-zipper_OmpA PF13436.6 EMD64980.1 - 2.4 8.0 5.8 10 6.0 0.5 2.3 2 0 0 2 2 2 0 Glycine-zipper domain ATPase_gene1 PF09527.10 EMD64980.1 - 7 6.9 11.0 4.4 7.5 0.6 3.3 3 0 0 3 3 3 0 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter Translin PF01997.16 EMD64981.1 - 3.3e-48 164.4 0.0 3.9e-48 164.2 0.0 1.0 1 0 0 1 1 1 1 Translin family HrpB2 PF09487.10 EMD64981.1 - 0.037 14.5 0.1 0.071 13.6 0.1 1.5 1 0 0 1 1 1 0 Bacterial type III secretion protein (HrpB2) PLU-1 PF08429.11 EMD64981.1 - 0.043 13.0 0.2 0.072 12.3 0.2 1.4 1 1 0 1 1 1 0 PLU-1-like protein Chs7 PF12271.8 EMD64984.1 - 6.5e-123 409.7 20.3 7.4e-123 409.5 20.3 1.0 1 0 0 1 1 1 1 Chitin synthase export chaperone DUF4281 PF14108.6 EMD64984.1 - 0.0054 17.1 5.2 0.012 15.9 5.2 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4281) DUF3382 PF11862.8 EMD64984.1 - 0.054 13.8 1.0 0.054 13.8 1.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3382) O-ag_pol_Wzy PF14296.6 EMD64984.1 - 2.4 6.7 24.2 1.4 7.5 4.5 2.1 2 0 0 2 2 2 0 O-antigen polysaccharide polymerase Wzy FAD_binding_3 PF01494.19 EMD64985.1 - 8e-71 239.1 0.0 1.8e-70 237.9 0.0 1.6 1 1 0 1 1 1 1 FAD binding domain Phe_hydrox_dim PF07976.12 EMD64985.1 - 3.9e-44 150.6 0.0 8.5e-44 149.5 0.0 1.6 1 0 0 1 1 1 1 Phenol hydroxylase, C-terminal dimerisation domain Pyr_redox_2 PF07992.14 EMD64985.1 - 0.0033 16.7 0.4 0.032 13.5 0.1 2.4 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase SE PF08491.10 EMD64985.1 - 0.0099 15.0 0.0 0.8 8.7 0.0 2.2 2 0 0 2 2 2 2 Squalene epoxidase DAO PF01266.24 EMD64985.1 - 0.082 12.5 0.1 2.2 7.8 0.1 2.4 2 0 0 2 2 2 0 FAD dependent oxidoreductase SPX PF03105.19 EMD64987.1 - 5 6.9 9.4 6.5 6.6 9.4 1.1 1 0 0 1 1 1 0 SPX domain DUF1387 PF07139.11 EMD64988.1 - 6.7 6.3 4.9 11 5.7 4.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) ADH_N PF08240.12 EMD64989.1 - 8.2e-26 90.0 2.1 1.4e-25 89.3 2.1 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EMD64989.1 - 1.9e-25 89.3 0.0 3.1e-25 88.6 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EMD64989.1 - 8.6e-10 38.5 0.0 1.3e-09 37.9 0.0 1.3 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 EMD64989.1 - 1e-09 39.5 0.0 1.9e-09 38.7 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 3A PF00803.18 EMD64989.1 - 0.0057 16.0 0.0 0.0076 15.6 0.0 1.2 1 0 0 1 1 1 1 3A/RNA2 movement protein family FAD_binding_3 PF01494.19 EMD64989.1 - 0.034 13.4 0.1 0.047 12.9 0.1 1.2 1 0 0 1 1 1 0 FAD binding domain Shikimate_DH PF01488.20 EMD64989.1 - 0.068 13.2 0.0 0.11 12.5 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Response_reg PF00072.24 EMD64990.1 - 2.9e-24 85.4 0.7 8.1e-24 84.0 0.7 1.8 1 0 0 1 1 1 1 Response regulator receiver domain HATPase_c PF02518.26 EMD64990.1 - 2.3e-20 73.2 0.0 5.4e-20 72.0 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 EMD64990.1 - 1.1e-07 31.8 0.1 4.2e-07 29.9 0.1 2.2 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain PAS_3 PF08447.12 EMD64990.1 - 7.8e-07 29.3 0.0 0.04 14.2 0.0 2.9 2 0 0 2 2 2 2 PAS fold PAS_9 PF13426.7 EMD64990.1 - 2.5e-06 27.7 0.0 0.015 15.5 0.0 2.7 2 0 0 2 2 2 2 PAS domain PAS PF00989.25 EMD64990.1 - 4.9e-06 26.5 0.0 0.013 15.5 0.0 2.7 2 0 0 2 2 2 2 PAS fold PAS_8 PF13188.7 EMD64990.1 - 1.1e-05 25.3 0.0 0.0082 16.2 0.0 2.7 2 0 0 2 2 2 2 PAS domain PAS_4 PF08448.10 EMD64990.1 - 5.9e-05 23.3 0.0 0.74 10.1 0.0 3.4 2 1 1 3 3 3 2 PAS fold HATPase_c_3 PF13589.6 EMD64990.1 - 0.086 12.7 0.3 0.31 10.9 0.0 2.1 2 0 0 2 2 2 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Mito_fiss_reg PF05308.11 EMD64991.1 - 0.3 11.1 8.5 0.5 10.4 8.5 1.3 1 0 0 1 1 1 0 Mitochondrial fission regulator V_ATPase_I PF01496.19 EMD64991.1 - 0.36 8.7 6.8 0.39 8.6 6.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Atg14 PF10186.9 EMD64991.1 - 0.47 9.5 11.8 0.67 9.0 11.8 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 PRKG1_interact PF15898.5 EMD64991.1 - 1.7 9.6 21.5 0.18 12.7 4.5 2.3 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain MDFI PF15316.6 EMD64991.1 - 3.1 7.9 10.6 0.68 10.0 3.4 2.3 2 0 0 2 2 2 0 MyoD family inhibitor TRAPP PF04051.16 EMD64992.1 - 4.6e-39 133.4 0.0 5.6e-39 133.2 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Thioredoxin PF00085.20 EMD64993.1 - 2.3e-26 91.8 1.2 3.8e-26 91.1 0.0 1.7 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_8 PF13905.6 EMD64993.1 - 6.7e-08 32.8 0.0 9.9e-06 25.8 0.0 2.2 1 1 1 2 2 2 2 Thioredoxin-like Thioredoxin_2 PF13098.6 EMD64993.1 - 2.9e-07 30.9 2.8 4.8e-07 30.2 0.4 2.3 2 1 0 2 2 2 1 Thioredoxin-like domain OST3_OST6 PF04756.13 EMD64993.1 - 6.1e-06 25.8 0.0 6.5e-06 25.7 0.0 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family AhpC-TSA PF00578.21 EMD64993.1 - 0.00024 21.0 0.8 0.13 12.2 0.1 2.6 2 1 1 3 3 3 2 AhpC/TSA family TraF PF13728.6 EMD64993.1 - 0.0014 18.5 0.0 0.0014 18.5 0.0 2.1 2 0 0 2 2 2 1 F plasmid transfer operon protein Thioredoxin_7 PF13899.6 EMD64993.1 - 0.0015 18.7 0.0 0.0023 18.1 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like Redoxin PF08534.10 EMD64993.1 - 0.0034 17.1 0.7 0.64 9.7 0.3 2.3 1 1 1 2 2 2 2 Redoxin Thioredoxin_9 PF14595.6 EMD64993.1 - 0.014 15.2 1.0 0.019 14.7 0.0 1.6 2 0 0 2 2 2 0 Thioredoxin DUF953 PF06110.11 EMD64993.1 - 0.04 13.5 1.2 0.13 11.9 0.0 2.2 2 1 0 2 2 2 0 Eukaryotic protein of unknown function (DUF953) DSBA PF01323.20 EMD64993.1 - 8.1 6.2 7.0 2.2 8.0 0.1 2.6 2 1 1 3 3 3 0 DSBA-like thioredoxin domain Thioredoxin PF00085.20 EMD64994.1 - 5.9e-59 196.4 0.1 9.3e-30 102.7 0.0 2.4 2 0 0 2 2 2 2 Thioredoxin ERp29 PF07749.12 EMD64994.1 - 3.2e-23 82.4 1.8 8.7e-23 81.0 0.9 2.1 2 0 0 2 2 2 1 Endoplasmic reticulum protein ERp29, C-terminal domain Thioredoxin_2 PF13098.6 EMD64994.1 - 5.7e-17 62.1 0.0 1.5e-07 31.8 0.0 2.9 2 0 0 2 2 2 2 Thioredoxin-like domain OST3_OST6 PF04756.13 EMD64994.1 - 2.1e-14 53.6 0.0 1.3e-06 28.0 0.0 2.2 1 1 1 2 2 2 2 OST3 / OST6 family, transporter family Thioredoxin_7 PF13899.6 EMD64994.1 - 4.8e-09 36.3 0.0 0.0015 18.6 0.0 2.5 2 0 0 2 2 2 2 Thioredoxin-like AhpC-TSA PF00578.21 EMD64994.1 - 2e-08 34.2 0.1 0.001 19.0 0.0 2.7 3 1 1 4 4 4 2 AhpC/TSA family Thioredoxin_8 PF13905.6 EMD64994.1 - 3.3e-08 33.8 0.0 0.0059 16.9 0.0 4.2 3 2 2 5 5 5 2 Thioredoxin-like ERp29_N PF07912.13 EMD64994.1 - 1.3e-07 31.8 0.4 0.00015 21.9 0.0 2.7 3 0 0 3 3 3 2 ERp29, N-terminal domain HyaE PF07449.11 EMD64994.1 - 2.2e-05 24.4 0.0 0.11 12.4 0.0 2.5 2 0 0 2 2 2 2 Hydrogenase-1 expression protein HyaE Thioredoxin_9 PF14595.6 EMD64994.1 - 3.7e-05 23.5 0.0 0.017 14.9 0.0 2.5 2 0 0 2 2 2 2 Thioredoxin TraF PF13728.6 EMD64994.1 - 0.00019 21.3 0.0 0.056 13.2 0.0 2.2 2 0 0 2 2 2 2 F plasmid transfer operon protein Redoxin PF08534.10 EMD64994.1 - 0.00023 20.9 0.3 0.33 10.7 0.0 2.4 2 0 0 2 2 2 2 Redoxin Thioredoxin_4 PF13462.6 EMD64994.1 - 0.0024 18.1 1.8 1.4 9.0 0.0 3.7 3 2 1 4 4 4 1 Thioredoxin Thioredoxin_3 PF13192.6 EMD64994.1 - 0.0037 17.3 0.0 0.5 10.5 0.0 2.5 2 0 0 2 2 2 1 Thioredoxin domain Glutaredoxin PF00462.24 EMD64994.1 - 0.016 15.4 0.8 4.9 7.4 0.1 3.1 2 2 0 2 2 2 0 Glutaredoxin HSBP1 PF06825.12 EMD64995.1 - 1.4e-20 72.8 0.3 1.6e-20 72.6 0.3 1.1 1 0 0 1 1 1 1 Heat shock factor binding protein 1 CLZ PF16526.5 EMD64995.1 - 0.0055 17.0 0.0 0.0061 16.9 0.0 1.1 1 0 0 1 1 1 1 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Matrilin_ccoil PF10393.9 EMD64995.1 - 0.011 15.6 0.2 0.046 13.6 0.2 1.8 1 1 0 1 1 1 0 Trimeric coiled-coil oligomerisation domain of matrilin Baculo_PEP_C PF04513.12 EMD64995.1 - 0.015 15.4 0.6 0.017 15.2 0.6 1.1 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Apolipoprotein PF01442.18 EMD64995.1 - 0.045 13.6 0.0 0.05 13.5 0.0 1.0 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain SRA1 PF07304.11 EMD64995.1 - 0.059 13.2 0.0 0.063 13.1 0.0 1.0 1 0 0 1 1 1 0 Steroid receptor RNA activator (SRA1) BLOC1_2 PF10046.9 EMD64995.1 - 0.061 13.6 0.0 0.072 13.4 0.0 1.1 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 NPV_P10 PF05531.12 EMD64995.1 - 0.096 13.2 0.4 0.19 12.2 0.3 1.5 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein Ebp2 PF05890.12 EMD64996.1 - 7.2e-99 330.7 18.8 7.2e-99 330.7 18.8 2.3 2 1 0 2 2 2 1 Eukaryotic rRNA processing protein EBP2 BUD22 PF09073.10 EMD64996.1 - 5.7 6.2 52.4 0.27 10.5 31.6 2.3 2 0 0 2 2 2 0 BUD22 PNISR PF15996.5 EMD64996.1 - 8.4 6.6 41.6 0.12 12.7 21.6 2.4 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR ADH_zinc_N_2 PF13602.6 EMD64997.1 - 3.2e-29 102.7 0.0 5.1e-29 102.0 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 EMD64997.1 - 1.9e-15 57.0 0.0 4.9e-15 55.7 0.0 1.7 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EMD64997.1 - 2.1e-06 27.6 0.6 0.00023 21.0 0.0 3.0 2 1 0 3 3 3 1 Alcohol dehydrogenase GroES-like domain DUF3456 PF11938.8 EMD64998.1 - 0.29 11.6 3.4 0.65 10.5 1.4 2.0 2 0 0 2 2 2 0 TLR4 regulator and MIR-interacting MSAP Fungal_trans PF04082.18 EMD65000.1 - 6.9e-25 87.6 1.0 1.3e-24 86.7 0.2 1.7 1 1 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD65000.1 - 2.2e-07 30.9 9.0 3.4e-07 30.3 9.0 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Gal4_dimer PF03902.13 EMD65000.1 - 3.1e-07 30.4 0.0 7.5e-07 29.2 0.0 1.7 1 0 0 1 1 1 1 Gal4-like dimerisation domain Cript PF10235.9 EMD65000.1 - 0.48 11.0 3.9 1 10.0 3.9 1.4 1 0 0 1 1 1 0 Microtubule-associated protein CRIPT AAA_33 PF13671.6 EMD65001.1 - 2.5e-06 27.7 0.2 0.018 15.2 0.0 2.3 2 0 0 2 2 2 2 AAA domain MeaB PF03308.16 EMD65001.1 - 6e-06 25.4 0.0 8.8e-06 24.9 0.0 1.2 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_18 PF13238.6 EMD65001.1 - 0.00058 20.4 0.1 0.0024 18.4 0.1 2.0 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 EMD65001.1 - 0.001 18.4 0.0 0.0017 17.7 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin PRK PF00485.18 EMD65001.1 - 0.0015 18.3 0.0 0.0029 17.4 0.0 1.4 1 1 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_16 PF13191.6 EMD65001.1 - 0.021 15.2 0.1 0.027 14.9 0.1 1.5 1 1 0 1 1 1 0 AAA ATPase domain APS_kinase PF01583.20 EMD65001.1 - 0.025 14.5 0.0 0.055 13.4 0.0 1.6 2 0 0 2 2 2 0 Adenylylsulphate kinase Thymidylate_kin PF02223.17 EMD65001.1 - 0.028 14.1 0.0 0.64 9.7 0.0 2.2 2 0 0 2 2 2 0 Thymidylate kinase AAA_17 PF13207.6 EMD65001.1 - 0.045 14.2 0.1 1.6 9.1 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 EMD65001.1 - 0.058 13.1 0.1 0.098 12.4 0.1 1.5 1 1 0 1 1 1 0 AAA domain KTI12 PF08433.10 EMD65001.1 - 0.061 12.8 0.0 0.088 12.2 0.0 1.2 1 0 0 1 1 1 0 Chromatin associated protein KTI12 FtsK_SpoIIIE PF01580.18 EMD65001.1 - 0.067 12.5 0.0 0.12 11.8 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family DUF815 PF05673.13 EMD65001.1 - 0.07 12.3 0.0 0.1 11.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) RsgA_GTPase PF03193.16 EMD65001.1 - 0.13 12.1 0.0 0.19 11.6 0.0 1.2 1 0 0 1 1 1 0 RsgA GTPase MMR_HSR1 PF01926.23 EMD65001.1 - 0.16 12.1 0.0 0.28 11.3 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase NB-ARC PF00931.22 EMD65001.1 - 0.22 10.7 0.0 0.34 10.0 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain Sugar_tr PF00083.24 EMD65002.1 - 1.6e-121 406.4 19.3 2.6e-121 405.6 19.3 1.3 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD65002.1 - 4.1e-22 78.6 51.1 4.8e-11 42.2 26.8 2.6 2 1 0 2 2 2 2 Major Facilitator Superfamily SH3_1 PF00018.28 EMD65004.1 - 3.4e-06 26.6 0.0 8e-06 25.4 0.0 1.7 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EMD65004.1 - 0.1 12.5 0.0 0.22 11.4 0.0 1.6 1 0 0 1 1 1 0 Variant SH3 domain SH3_16 PF18348.1 EMD65004.1 - 0.14 12.0 0.0 0.31 10.9 0.0 1.6 1 0 0 1 1 1 0 Bacterial dipeptidyl-peptidase Sh3 domain HET PF06985.11 EMD65005.1 - 4.4e-16 59.6 0.2 5.4e-16 59.2 0.2 1.1 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) DUF4758 PF15950.5 EMD65005.1 - 0.12 12.7 0.0 0.16 12.3 0.0 1.2 1 0 0 1 1 1 0 Putative sperm flagellar membrane protein DIOX_N PF14226.6 EMD65006.1 - 0.008 16.9 0.0 0.018 15.8 0.0 1.5 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EMD65006.1 - 0.025 15.0 0.0 0.051 14.1 0.0 1.6 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily GCV_T PF01571.21 EMD65007.1 - 1.9e-07 30.7 0.0 2.7e-07 30.2 0.0 1.3 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain Lung_7-TM_R PF06814.13 EMD65008.1 - 5.9e-68 229.3 19.5 7.5e-68 228.9 19.5 1.1 1 0 0 1 1 1 1 Lung seven transmembrane receptor CTU2 PF10288.9 EMD65009.1 - 7.5e-15 55.2 0.9 8.3e-12 45.4 0.0 2.7 3 0 0 3 3 3 2 Cytoplasmic tRNA 2-thiolation protein 2 HA2 PF04408.23 EMD65010.1 - 5.2e-20 71.7 2.3 1.1e-18 67.4 0.0 2.8 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EMD65010.1 - 1.1e-16 60.9 0.0 2.4e-16 59.9 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EMD65010.1 - 1.8e-12 47.6 0.0 4.6e-12 46.3 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain RWD PF05773.22 EMD65010.1 - 7.2e-12 45.6 0.0 1.7e-11 44.4 0.0 1.7 1 0 0 1 1 1 1 RWD domain DEAD PF00270.29 EMD65010.1 - 7.3e-09 35.6 0.3 1.4e-08 34.7 0.3 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EMD65010.1 - 0.0011 19.3 0.9 0.0035 17.6 0.9 1.9 1 1 0 1 1 1 1 AAA domain DND1_DSRM PF14709.7 EMD65010.1 - 0.01 16.1 0.0 0.027 14.7 0.0 1.8 1 0 0 1 1 1 1 double strand RNA binding domain from DEAD END PROTEIN 1 AAA_29 PF13555.6 EMD65010.1 - 0.036 13.8 0.0 0.15 11.8 0.0 2.0 2 0 0 2 2 2 0 P-loop containing region of AAA domain ATPase PF06745.13 EMD65010.1 - 0.089 12.1 0.0 0.21 10.9 0.0 1.6 1 0 0 1 1 1 0 KaiC T2SSE PF00437.20 EMD65010.1 - 0.1 11.7 0.2 0.25 10.4 0.0 1.6 2 0 0 2 2 2 0 Type II/IV secretion system protein PhoH PF02562.16 EMD65010.1 - 0.13 11.7 0.0 0.25 10.8 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein UBA PF00627.31 EMD65010.1 - 0.16 11.9 0.4 1.7 8.6 0.0 2.5 2 0 0 2 2 2 0 UBA/TS-N domain AAA_23 PF13476.6 EMD65010.1 - 0.41 11.1 3.0 0.53 10.7 0.2 2.4 2 0 0 2 2 2 0 AAA domain tRNA_anti-like PF12869.7 EMD65010.1 - 1 9.0 6.1 0.35 10.5 0.3 2.7 3 0 0 3 3 3 0 tRNA_anti-like zf_CCCH_4 PF18345.1 EMD65011.1 - 1e-05 25.4 11.7 0.012 15.7 0.2 3.7 3 0 0 3 3 3 2 Zinc finger domain zf-CCCH PF00642.24 EMD65011.1 - 0.015 15.2 17.6 0.042 13.8 1.1 3.9 4 0 0 4 4 4 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 EMD65011.1 - 0.024 14.5 16.0 0.33 10.8 0.7 4.0 3 0 0 3 3 3 0 CCCH-type zinc finger Torus PF16131.5 EMD65011.1 - 0.21 12.3 7.4 0.38 11.5 0.1 2.9 2 1 1 3 3 3 0 Torus domain ADAM_CR_2 PF17771.1 EMD65011.1 - 1.2 9.8 6.5 0.082 13.4 1.2 1.9 2 0 0 2 2 2 0 ADAM cysteine-rich domain TRAP_alpha PF03896.16 EMD65012.1 - 3.6e-07 29.7 1.7 6e-06 25.7 1.7 2.1 1 1 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit DUF4805 PF16063.5 EMD65013.1 - 0.22 10.8 4.9 0.25 10.7 4.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4805) MFS_1 PF07690.16 EMD65014.1 - 4.7e-31 108.0 36.4 6.6e-31 107.5 36.4 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily GFO_IDH_MocA PF01408.22 EMD65015.1 - 5.9e-16 59.4 0.0 1e-15 58.6 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 EMD65015.1 - 1.3e-05 25.1 0.0 2.3e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain DUF3138 PF11336.8 EMD65016.1 - 0.18 10.4 4.0 3.7 6.0 0.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3138) DivIC PF04977.15 EMD65016.1 - 0.84 9.5 4.5 1.6 8.5 0.1 2.5 2 0 0 2 2 2 0 Septum formation initiator Pam16 PF03656.13 EMD65016.1 - 1.6 8.8 6.2 1.3 9.1 2.0 2.8 2 0 0 2 2 2 0 Pam16 HalX PF08663.10 EMD65016.1 - 2.4 8.6 10.8 4.6 7.6 0.2 2.6 2 0 0 2 2 2 0 HalX domain RRM_1 PF00076.22 EMD65017.1 - 1.3e-12 47.4 0.1 2.1e-12 46.7 0.1 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TPD52 PF04201.15 EMD65018.1 - 0.12 12.0 2.0 0.17 11.5 2.0 1.2 1 0 0 1 1 1 0 Tumour protein D52 family F-box PF00646.33 EMD65020.1 - 1.3e-05 25.0 0.2 1.3e-05 25.0 0.2 2.4 3 0 0 3 3 3 1 F-box domain F-box-like PF12937.7 EMD65020.1 - 0.00032 20.5 0.2 0.00032 20.5 0.2 2.2 2 0 0 2 2 2 1 F-box-like DUF2614 PF11023.8 EMD65020.1 - 0.01 15.9 0.4 0.015 15.3 0.4 1.3 1 0 0 1 1 1 0 Zinc-ribbon containing domain FAM76 PF16046.5 EMD65020.1 - 0.096 12.0 5.9 0.14 11.5 5.9 1.2 1 0 0 1 1 1 0 FAM76 protein DZR PF12773.7 EMD65020.1 - 1.8 8.6 8.7 2.4 8.2 5.9 2.5 2 1 0 2 2 2 0 Double zinc ribbon Rhodanese_C PF12368.8 EMD65020.1 - 9.1 6.7 10.9 1.5 9.3 5.6 2.2 2 1 1 3 3 3 0 Rhodanase C-terminal PIG-L PF02585.17 EMD65021.1 - 1.3e-24 87.3 0.1 1.9e-24 86.8 0.1 1.2 1 0 0 1 1 1 1 GlcNAc-PI de-N-acetylase SLAC1 PF03595.17 EMD65023.1 - 2.5e-88 296.5 50.0 2.8e-88 296.3 50.0 1.0 1 0 0 1 1 1 1 Voltage-dependent anion channel DUF4956 PF16316.5 EMD65023.1 - 0.63 9.7 6.7 0.88 9.2 3.0 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4956) DUF3270 PF11674.8 EMD65023.1 - 4.2 7.6 9.1 1.7 8.9 0.3 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3270) Glyco_hydro_61 PF03443.14 EMD65024.1 - 1.3e-56 191.9 0.0 1.5e-56 191.6 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 CSD PF00313.22 EMD65024.1 - 0.037 13.9 0.0 0.073 12.9 0.0 1.5 1 0 0 1 1 1 0 'Cold-shock' DNA-binding domain PGP_phosphatase PF09419.10 EMD65025.1 - 1.9e-67 226.1 0.0 2.2e-67 225.9 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial PGP phosphatase Hydrolase_like PF13242.6 EMD65025.1 - 1.2e-06 28.5 0.1 2e-06 27.8 0.1 1.3 1 0 0 1 1 1 1 HAD-hyrolase-like LSM PF01423.22 EMD65026.1 - 3e-16 58.9 0.2 3.8e-16 58.5 0.2 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EMD65026.1 - 0.1 12.7 0.0 0.19 11.9 0.0 1.4 1 1 0 1 1 1 0 Ataxin 2 SM domain Ribosomal_S21e PF01249.18 EMD65026.1 - 0.14 12.3 0.0 0.19 11.9 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein S21e Adaptin_binding PF10199.9 EMD65027.1 - 6.8e-13 49.3 5.6 1.8e-12 47.9 5.6 1.7 1 0 0 1 1 1 1 Alpha and gamma adaptin binding protein p34 REV1_C PF16727.5 EMD65027.1 - 0.082 13.3 2.3 0.86 10.0 0.2 2.3 2 0 0 2 2 2 0 DNA repair protein REV1 C-terminal domain Methyltransf_23 PF13489.6 EMD65028.1 - 3.6e-15 56.2 0.0 4.9e-15 55.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMD65028.1 - 6e-14 52.1 0.0 5.6e-13 49.0 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMD65028.1 - 3.9e-13 50.0 0.0 8.9e-13 48.8 0.0 1.6 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMD65028.1 - 8.3e-13 48.9 0.0 4e-11 43.5 0.0 2.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMD65028.1 - 9.8e-12 45.4 0.1 9.2e-11 42.2 0.0 2.3 2 1 0 2 2 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 EMD65028.1 - 0.0033 17.4 0.0 0.0046 16.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain NodS PF05401.11 EMD65028.1 - 0.0049 16.5 0.0 0.0085 15.7 0.0 1.4 1 0 0 1 1 1 1 Nodulation protein S (NodS) MTS PF05175.14 EMD65028.1 - 0.0092 15.5 0.0 0.016 14.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_16 PF10294.9 EMD65028.1 - 0.0094 15.7 0.2 0.053 13.2 0.2 2.3 1 1 1 2 2 2 1 Lysine methyltransferase Ubie_methyltran PF01209.18 EMD65028.1 - 0.026 13.9 0.0 0.52 9.6 0.0 2.4 2 1 0 2 2 2 0 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.17 EMD65028.1 - 0.032 13.7 0.0 2.7 7.4 0.0 2.2 2 0 0 2 2 2 0 Putative methyltransferase Methyltransf_9 PF08003.11 EMD65028.1 - 0.079 11.9 0.0 1.6 7.6 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1698) Pox_MCEL PF03291.16 EMD65028.1 - 0.14 11.2 0.0 0.25 10.4 0.0 1.5 1 1 0 1 1 1 0 mRNA capping enzyme PCMT PF01135.19 EMD65028.1 - 0.19 11.5 0.0 0.3 10.8 0.0 1.4 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) tRNA_U5-meth_tr PF05958.11 EMD65028.1 - 0.22 10.5 0.0 0.29 10.1 0.0 1.1 1 0 0 1 1 1 0 tRNA (Uracil-5-)-methyltransferase vWA-TerF-like PF10138.9 EMD65029.1 - 0.00034 20.8 0.0 0.00055 20.1 0.0 1.4 1 1 0 1 1 1 1 vWA found in TerF C terminus Extensin_2 PF04554.13 EMD65029.1 - 0.47 10.6 59.6 0.11 12.6 22.6 3.6 2 1 1 3 3 3 0 Extensin-like region Ribonuclease PF00545.20 EMD65031.1 - 1.1e-07 32.4 0.9 1.6e-07 32.0 0.9 1.3 1 0 0 1 1 1 1 ribonuclease Bestrophin PF01062.21 EMD65032.1 - 1.8e-55 188.5 0.0 8.2e-55 186.3 0.0 1.8 1 1 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel YrvL PF14184.6 EMD65032.1 - 0.048 13.8 0.6 0.048 13.8 0.6 1.6 2 0 0 2 2 2 0 Regulatory protein YrvL FHA PF00498.26 EMD65033.1 - 2.6e-16 59.7 0.0 5.1e-16 58.8 0.0 1.5 1 0 0 1 1 1 1 FHA domain zf-RING_11 PF17123.5 EMD65033.1 - 5.9e-13 48.3 6.6 1.1e-12 47.4 6.6 1.5 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_2 PF13639.6 EMD65033.1 - 3.4e-07 30.5 8.8 6.5e-07 29.6 8.8 1.5 1 0 0 1 1 1 1 Ring finger domain Yop-YscD_cpl PF16697.5 EMD65033.1 - 4.2e-05 23.8 0.0 9.2e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain zf-C3HC4_2 PF13923.6 EMD65033.1 - 0.0032 17.3 8.4 0.0061 16.4 8.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMD65033.1 - 0.0052 16.6 7.6 0.0094 15.8 7.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) PHD PF00628.29 EMD65033.1 - 0.012 15.5 4.1 0.023 14.6 4.1 1.5 1 0 0 1 1 1 0 PHD-finger zf-ANAPC11 PF12861.7 EMD65033.1 - 0.016 15.3 2.9 0.027 14.5 2.9 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.6 EMD65033.1 - 0.019 14.9 4.8 0.033 14.1 4.8 1.4 1 0 0 1 1 1 0 zinc-RING finger domain DUF2956 PF11169.8 EMD65033.1 - 0.058 13.6 0.0 0.13 12.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2956) Peptidase_U40 PF10464.9 EMD65033.1 - 0.11 12.1 0.0 0.2 11.3 0.0 1.3 1 0 0 1 1 1 0 Peptidase U40 zf-rbx1 PF12678.7 EMD65033.1 - 0.14 12.5 9.7 0.5 10.7 9.7 1.9 1 1 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 EMD65033.1 - 0.33 11.0 7.9 0.7 10.0 7.9 1.6 1 0 0 1 1 1 0 RING-type zinc-finger Zn_ribbon_17 PF17120.5 EMD65033.1 - 2 8.1 8.8 2.1 8.0 7.1 1.9 1 1 1 2 2 2 0 Zinc-ribbon, C4HC2 type Peptidase_M16_C PF05193.21 EMD65034.1 - 5.9e-51 173.1 0.0 9.6e-51 172.4 0.0 1.4 1 0 0 1 1 1 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EMD65034.1 - 1.2e-39 135.7 0.0 2.5e-39 134.6 0.0 1.6 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) HET PF06985.11 EMD65035.1 - 2.8e-12 47.2 5.0 1.9e-09 38.0 1.1 3.1 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) NACHT PF05729.12 EMD65035.1 - 5.7e-11 42.6 0.2 1.4e-10 41.4 0.2 1.7 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 EMD65035.1 - 0.0044 17.4 0.0 0.022 15.1 0.0 2.2 2 0 0 2 2 2 1 AAA ATPase domain RNA_helicase PF00910.22 EMD65035.1 - 0.0051 17.2 0.1 0.02 15.3 0.0 2.2 2 0 0 2 2 2 1 RNA helicase zf_C2H2_13 PF18508.1 EMD65035.1 - 0.0071 15.9 0.3 0.02 14.5 0.3 1.8 1 0 0 1 1 1 1 Zinc finger domain AAA PF00004.29 EMD65035.1 - 0.0083 16.5 0.0 0.038 14.4 0.0 2.2 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) NB-ARC PF00931.22 EMD65035.1 - 0.012 14.9 0.1 0.037 13.2 0.1 1.9 1 1 0 1 1 1 0 NB-ARC domain AAA_14 PF13173.6 EMD65035.1 - 0.029 14.4 0.0 0.2 11.7 0.0 2.3 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EMD65035.1 - 0.052 13.8 0.0 0.21 11.9 0.0 2.0 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 EMD65035.1 - 0.065 12.6 0.7 12 5.1 0.2 2.6 3 0 0 3 3 3 0 KaiC Spidroin_N PF16763.5 EMD65036.1 - 0.17 11.9 3.7 0.083 12.9 1.1 1.7 2 0 0 2 2 2 0 Major ampullate spidroin 1, spider silk protein 1, N-term Mpv17_PMP22 PF04117.12 EMD65037.1 - 4.9e-12 45.9 3.9 3.2e-11 43.3 2.8 2.1 1 1 1 2 2 2 1 Mpv17 / PMP22 family DUF2232 PF09991.9 EMD65037.1 - 0.027 13.6 2.2 0.41 9.8 0.1 2.4 2 1 1 3 3 3 0 Predicted membrane protein (DUF2232) NADH_oxidored PF08040.11 EMD65037.1 - 0.12 12.1 0.0 0.28 10.9 0.0 1.6 1 0 0 1 1 1 0 MNLL subunit Serinc PF03348.15 EMD65037.1 - 0.16 10.9 2.9 0.23 10.3 2.9 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) SprT-like PF10263.9 EMD65038.1 - 0.00028 20.7 0.1 0.00091 19.1 0.1 1.8 1 0 0 1 1 1 1 SprT-like family GAS PF13851.6 EMD65038.1 - 0.0062 15.9 2.3 0.029 13.7 3.1 1.6 2 0 0 2 2 2 1 Growth-arrest specific micro-tubule binding NAM-associated PF14303.6 EMD65038.1 - 0.1 13.3 0.2 0.17 12.6 0.2 1.2 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain Bcr-Abl_Oligo PF09036.10 EMD65038.1 - 0.13 12.3 1.2 0.41 10.7 1.2 1.9 1 0 0 1 1 1 0 Bcr-Abl oncoprotein oligomerisation domain EMP24_GP25L PF01105.24 EMD65038.1 - 0.14 12.1 0.2 0.22 11.5 0.2 1.2 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD DUF724 PF05266.14 EMD65038.1 - 0.86 9.4 3.6 1.7 8.5 3.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF724) TPR_12 PF13424.6 EMD65040.1 - 5.8e-29 100.2 13.3 2.2e-08 34.3 0.9 5.6 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_10 PF13374.6 EMD65040.1 - 1.6e-25 88.2 10.2 0.00037 20.2 0.0 8.0 7 1 0 7 7 7 5 Tetratricopeptide repeat TPR_2 PF07719.17 EMD65040.1 - 8.7e-14 50.5 9.8 0.0056 16.7 0.0 7.5 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_1 PF00515.28 EMD65040.1 - 8.8e-10 38.0 9.7 0.044 13.6 0.1 6.4 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_14 PF13428.6 EMD65040.1 - 1.6e-08 34.7 5.7 2.9 8.9 0.0 7.3 7 1 0 7 7 7 2 Tetratricopeptide repeat TPR_8 PF13181.6 EMD65040.1 - 4.3e-08 32.8 8.4 0.075 13.3 0.2 5.7 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.6 EMD65040.1 - 2.4e-06 27.2 16.7 0.034 14.2 0.0 8.2 8 2 0 8 8 8 2 Tetratricopeptide repeat TPR_16 PF13432.6 EMD65040.1 - 2.6e-06 28.0 0.4 2.3 9.0 0.0 6.1 5 2 1 6 6 6 1 Tetratricopeptide repeat TPR_MalT PF17874.1 EMD65040.1 - 4.4e-05 23.0 0.3 0.11 11.9 0.1 2.8 2 1 0 2 2 2 2 MalT-like TPR region TPR_19 PF14559.6 EMD65040.1 - 6.8e-05 23.3 0.5 0.99 10.0 0.0 5.0 2 2 3 5 5 5 2 Tetratricopeptide repeat TPR_4 PF07721.14 EMD65040.1 - 0.00022 21.5 2.0 13 6.8 0.0 5.8 6 0 0 6 6 5 0 Tetratricopeptide repeat PPR PF01535.20 EMD65040.1 - 0.00051 20.1 8.9 8.5 6.9 0.0 5.9 5 0 0 5 5 5 1 PPR repeat TPR_17 PF13431.6 EMD65040.1 - 0.007 16.7 0.0 1.1e+02 3.5 0.0 4.9 5 0 0 5 5 4 0 Tetratricopeptide repeat zf_CopZ PF18423.1 EMD65040.1 - 0.82 9.7 2.6 0.46 10.5 0.1 1.9 2 0 0 2 2 1 0 Zinc binding domain FapA PF03961.13 EMD65041.1 - 0.029 13.0 0.6 0.03 12.9 0.6 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF4709 PF15821.5 EMD65041.1 - 0.23 11.8 2.7 0.37 11.1 2.7 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4709) ISN1 PF06437.11 EMD65042.1 - 0.13 11.1 0.0 0.15 10.9 0.0 1.0 1 0 0 1 1 1 0 IMP-specific 5'-nucleotidase LDB19 PF13002.7 EMD65043.1 - 1.4e-51 175.0 0.3 3e-51 173.9 0.3 1.6 2 0 0 2 2 2 1 Arrestin_N terminal like Arrestin_N PF00339.29 EMD65043.1 - 2e-05 24.7 0.0 4.8e-05 23.4 0.0 1.6 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Spo0M PF07070.11 EMD65043.1 - 0.13 11.8 0.0 0.2 11.2 0.0 1.3 1 0 0 1 1 1 0 SpoOM protein Ribosomal_L22e PF01776.17 EMD65044.1 - 4.8e-48 162.1 2.1 6.1e-48 161.7 2.1 1.0 1 0 0 1 1 1 1 Ribosomal L22e protein family SQS_PSY PF00494.19 EMD65045.1 - 1.5e-53 182.0 0.0 2.4e-53 181.3 0.0 1.3 1 0 0 1 1 1 1 Squalene/phytoene synthase SNF2_N PF00176.23 EMD65046.1 - 4.3e-71 239.5 0.0 5.7e-71 239.0 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain HIRAN PF08797.11 EMD65046.1 - 4.3e-20 71.4 0.0 1e-19 70.3 0.0 1.7 1 0 0 1 1 1 1 HIRAN domain Helicase_C PF00271.31 EMD65046.1 - 7e-15 55.3 0.0 1.6e-14 54.2 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EMD65046.1 - 9.7e-06 25.7 0.2 3.1e-05 24.0 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit zf-C3HC4 PF00097.25 EMD65046.1 - 0.00064 19.5 13.3 0.0012 18.6 13.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EMD65046.1 - 0.00097 19.0 10.9 0.0017 18.1 10.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EMD65046.1 - 0.0016 18.2 8.2 0.0034 17.2 8.2 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EMD65046.1 - 0.0025 18.1 12.2 0.0057 17.0 12.2 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 EMD65046.1 - 0.038 14.0 10.4 0.078 13.0 10.4 1.5 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_5 PF14634.6 EMD65046.1 - 0.068 13.1 9.6 0.17 11.9 9.6 1.7 1 0 0 1 1 1 0 zinc-RING finger domain ERCC3_RAD25_C PF16203.5 EMD65046.1 - 0.078 12.2 0.0 0.14 11.3 0.0 1.3 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase Rrp15p PF07890.12 EMD65046.1 - 0.17 12.2 0.8 0.5 10.7 0.0 2.1 2 0 0 2 2 2 0 Rrp15p Asp PF00026.23 EMD65048.1 - 2.6e-11 43.5 0.0 4.9e-11 42.6 0.0 1.5 1 1 0 1 1 1 1 Eukaryotic aspartyl protease VSP PF03302.13 EMD65048.1 - 0.087 11.7 0.2 0.13 11.0 0.2 1.1 1 0 0 1 1 1 0 Giardia variant-specific surface protein Fungal_trans_2 PF11951.8 EMD65049.1 - 0.013 14.3 0.7 0.013 14.3 0.7 1.6 2 0 0 2 2 2 0 Fungal specific transcription factor domain Fungal_trans PF04082.18 EMD65050.1 - 2.9e-06 26.5 0.0 4.9e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain MFS_1 PF07690.16 EMD65051.1 - 1.2e-46 159.3 49.7 1.2e-46 159.3 49.7 2.7 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EMD65051.1 - 1.2e-09 37.2 26.8 1.6e-09 36.8 26.8 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) FAD_binding_4 PF01565.23 EMD65052.1 - 2.9e-23 82.1 0.8 4.6e-23 81.5 0.8 1.3 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EMD65052.1 - 0.00011 22.3 0.8 0.00026 21.0 0.8 1.6 1 0 0 1 1 1 1 Berberine and berberine like RNase_H PF00075.24 EMD65052.1 - 0.15 12.3 0.0 0.34 11.1 0.0 1.5 1 0 0 1 1 1 0 RNase H DUF1772 PF08592.11 EMD65053.1 - 4e-17 62.8 0.4 4.8e-17 62.6 0.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1772) adh_short PF00106.25 EMD65054.1 - 7.4e-22 77.8 0.1 7.7e-18 64.7 0.0 2.2 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EMD65054.1 - 7.7e-13 48.5 0.0 1.1e-09 38.2 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD65054.1 - 2.6e-09 37.3 0.2 3.9e-09 36.7 0.2 1.2 1 0 0 1 1 1 1 KR domain Shikimate_DH PF01488.20 EMD65054.1 - 0.1 12.7 0.0 0.29 11.2 0.0 1.7 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Fungal_trans PF04082.18 EMD65055.1 - 0.0004 19.5 0.0 0.00066 18.8 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain HemY_N PF07219.13 EMD65056.1 - 0.22 11.7 4.7 0.28 11.4 4.6 1.3 1 1 0 1 1 1 0 HemY protein N-terminus GTP_EFTU PF00009.27 EMD65057.1 - 2.3e-58 196.9 0.3 3.1e-58 196.5 0.3 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EMD65057.1 - 1e-25 90.2 0.0 2e-25 89.3 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EMD65057.1 - 6.8e-16 58.4 2.0 1.7e-15 57.1 2.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EMD65057.1 - 9e-06 25.7 0.1 1.9e-05 24.7 0.1 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EMD65057.1 - 0.00043 20.2 0.2 0.0015 18.5 0.1 1.9 1 1 1 2 2 2 1 RsgA GTPase PduV-EutP PF10662.9 EMD65057.1 - 0.0031 17.3 0.2 2.9 7.6 0.1 2.7 3 0 0 3 3 3 2 Ethanolamine utilisation - propanediol utilisation cobW PF02492.19 EMD65057.1 - 0.01 15.4 0.7 0.054 13.1 0.0 2.0 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Gtr1_RagA PF04670.12 EMD65057.1 - 0.089 12.1 0.3 0.32 10.3 0.3 1.7 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region ECH_2 PF16113.5 EMD65058.1 - 7.3e-126 420.2 0.0 1.1e-125 419.6 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 EMD65058.1 - 3.6e-31 108.4 0.0 5.1e-29 101.3 0.0 2.1 2 0 0 2 2 2 2 Enoyl-CoA hydratase/isomerase FAD_binding_4 PF01565.23 EMD65059.1 - 3.2e-17 62.6 0.1 5.7e-17 61.8 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EMD65059.1 - 3.8e-10 39.7 0.6 1.4e-09 37.9 0.1 2.3 3 0 0 3 3 3 1 Berberine and berberine like Cytokin-bind PF09265.10 EMD65059.1 - 0.2 11.0 0.0 0.31 10.4 0.0 1.2 1 0 0 1 1 1 0 Cytokinin dehydrogenase 1, FAD and cytokinin binding DNMT1-RFD PF12047.8 EMD65061.1 - 0.0008 19.5 0.1 0.0022 18.0 0.1 1.7 1 0 0 1 1 1 1 Cytosine specific DNA methyltransferase replication foci domain ACP_syn_III PF08545.10 EMD65061.1 - 0.11 12.4 0.0 0.2 11.6 0.0 1.3 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Vpu PF00558.19 EMD65061.1 - 0.18 11.6 0.8 2.4 8.0 0.0 2.6 2 0 0 2 2 2 0 Vpu protein GREB1 PF15782.5 EMD65061.1 - 8.2 3.4 6.2 13 2.8 6.2 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer CAF1C_H4-bd PF12265.8 EMD65062.1 - 2e-16 60.0 0.1 9.5e-16 57.8 0.0 2.3 3 0 0 3 3 3 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 EMD65062.1 - 4.4e-15 55.8 7.3 1.4e-06 28.9 0.1 3.9 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD65062.1 - 2.2e-07 31.1 0.8 0.0011 19.3 0.1 3.6 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain IKI3 PF04762.12 EMD65062.1 - 0.0065 14.5 0.2 0.0098 13.9 0.2 1.3 1 0 0 1 1 1 1 IKI3 family Ras PF00071.22 EMD65063.1 - 3e-31 108.2 0.2 4.4e-31 107.7 0.2 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMD65063.1 - 1.2e-23 83.6 0.1 2.8e-23 82.4 0.1 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMD65063.1 - 1.3e-06 27.9 0.1 1.8e-06 27.5 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EMD65063.1 - 8.3e-05 22.1 0.1 0.00013 21.4 0.1 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region DLIC PF05783.11 EMD65063.1 - 0.011 14.6 0.2 1.1 8.0 0.0 2.3 2 0 0 2 2 2 0 Dynein light intermediate chain (DLIC) AAA_35 PF14516.6 EMD65063.1 - 0.035 13.0 0.1 0.052 12.4 0.1 1.2 1 0 0 1 1 1 0 AAA-like domain G-alpha PF00503.20 EMD65063.1 - 0.36 9.9 3.9 0.58 9.2 0.1 2.6 1 1 2 3 3 3 0 G-protein alpha subunit EXOSC1 PF10447.9 EMD65064.1 - 8e-17 61.8 2.7 8.2e-11 42.5 0.8 2.2 1 1 1 2 2 2 2 Exosome component EXOSC1/CSL4 ECR1_N PF14382.6 EMD65064.1 - 1.1e-11 44.4 0.1 2.1e-11 43.4 0.1 1.5 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region SAM_1 PF00536.30 EMD65065.1 - 2e-13 50.6 0.0 3.2e-13 49.9 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) RA PF00788.23 EMD65065.1 - 3.7e-13 49.9 0.0 8.2e-13 48.8 0.0 1.5 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain SAM_2 PF07647.17 EMD65065.1 - 6.5e-13 48.6 0.0 1.2e-12 47.7 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) TMF_TATA_bd PF12325.8 EMD65065.1 - 0.0023 18.1 0.1 0.004 17.4 0.1 1.3 1 0 0 1 1 1 1 TATA element modulatory factor 1 TATA binding YabA PF06156.13 EMD65065.1 - 0.033 14.8 0.1 0.057 14.1 0.1 1.3 1 0 0 1 1 1 0 Initiation control protein YabA Herpes_pp85 PF04637.12 EMD65065.1 - 2.6 6.4 4.9 5.2 5.4 4.9 1.4 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) tRNA-synt_1c PF00749.21 EMD65066.1 - 0.01 14.8 0.0 0.011 14.7 0.0 1.1 1 0 0 1 1 1 0 tRNA synthetases class I (E and Q), catalytic domain EnY2 PF10163.9 EMD65066.1 - 0.1 12.9 0.0 0.33 11.3 0.0 2.0 1 1 0 1 1 1 0 Transcription factor e(y)2 AAA PF00004.29 EMD65067.1 - 8.6e-98 323.9 0.0 1.5e-47 161.3 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EMD65067.1 - 4.8e-22 77.5 3.7 2e-12 46.7 0.2 2.9 2 0 0 2 2 2 2 AAA+ lid domain CDC48_N PF02359.18 EMD65067.1 - 1.1e-18 67.2 1.1 2.6e-18 66.0 0.5 2.1 2 0 0 2 2 1 1 Cell division protein 48 (CDC48), N-terminal domain AAA_2 PF07724.14 EMD65067.1 - 3.3e-14 53.3 0.0 1e-07 32.2 0.0 2.7 2 1 0 2 2 2 2 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 EMD65067.1 - 7.1e-14 51.9 0.0 6.6e-06 26.0 0.0 3.3 4 1 0 4 4 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EMD65067.1 - 2.2e-12 47.7 0.0 9.9e-05 22.8 0.0 4.3 2 2 1 3 3 3 2 AAA ATPase domain AAA_33 PF13671.6 EMD65067.1 - 6.7e-12 45.8 0.0 1.9e-05 24.9 0.0 2.9 3 0 0 3 3 2 2 AAA domain AAA_5 PF07728.14 EMD65067.1 - 1.3e-10 41.4 0.5 2e-05 24.6 0.1 3.8 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) TIP49 PF06068.13 EMD65067.1 - 2.4e-09 36.9 0.6 0.0012 18.1 0.1 3.0 3 1 0 3 3 2 2 TIP49 P-loop domain AAA_22 PF13401.6 EMD65067.1 - 5.8e-09 36.4 0.3 0.048 13.9 0.0 4.2 2 2 1 3 3 3 2 AAA domain CDC48_2 PF02933.17 EMD65067.1 - 2.2e-07 30.5 0.1 5e-07 29.4 0.1 1.6 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 ATPase PF06745.13 EMD65067.1 - 3.7e-07 29.7 0.2 0.23 10.8 0.0 3.4 3 0 0 3 3 3 2 KaiC Mg_chelatase PF01078.21 EMD65067.1 - 4e-07 29.6 0.3 0.035 13.5 0.0 2.6 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 EMD65067.1 - 5.5e-07 30.0 0.0 0.025 15.0 0.0 2.8 2 0 0 2 2 2 2 RNA helicase IstB_IS21 PF01695.17 EMD65067.1 - 9.6e-07 28.7 0.0 0.038 13.7 0.0 2.8 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_18 PF13238.6 EMD65067.1 - 1.3e-06 29.0 0.0 0.058 13.9 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.6 EMD65067.1 - 1.8e-06 27.7 3.5 0.81 9.2 0.1 4.8 3 2 1 5 5 5 2 AAA domain AAA_14 PF13173.6 EMD65067.1 - 2.2e-06 27.7 0.0 0.016 15.2 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_7 PF12775.7 EMD65067.1 - 5.4e-06 26.0 0.0 0.04 13.4 0.0 3.1 2 2 0 2 2 2 2 P-loop containing dynein motor region Vps4_C PF09336.10 EMD65067.1 - 1.3e-05 25.1 0.2 0.00012 22.0 0.1 2.4 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain AAA_24 PF13479.6 EMD65067.1 - 1.7e-05 24.7 0.0 0.13 11.9 0.0 2.9 3 0 0 3 3 2 2 AAA domain DUF815 PF05673.13 EMD65067.1 - 3e-05 23.3 0.0 0.024 13.8 0.0 2.8 3 0 0 3 3 2 1 Protein of unknown function (DUF815) Parvo_NS1 PF01057.17 EMD65067.1 - 3e-05 23.3 0.1 0.1 11.6 0.0 2.3 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 Bac_DnaA PF00308.18 EMD65067.1 - 3.7e-05 23.7 0.0 0.21 11.4 0.0 3.4 4 0 0 4 4 4 2 Bacterial dnaA protein Sigma54_activat PF00158.26 EMD65067.1 - 4.8e-05 23.1 0.1 0.43 10.3 0.0 3.3 2 2 0 2 2 2 2 Sigma-54 interaction domain AAA_28 PF13521.6 EMD65067.1 - 7.3e-05 23.1 0.0 0.47 10.7 0.0 2.6 2 0 0 2 2 2 2 AAA domain ABC_tran PF00005.27 EMD65067.1 - 0.00014 22.4 0.0 0.48 10.9 0.0 3.4 2 1 0 2 2 2 1 ABC transporter PhoH PF02562.16 EMD65067.1 - 0.00019 21.0 0.4 0.47 9.9 0.0 2.5 2 0 0 2 2 2 2 PhoH-like protein AAA_17 PF13207.6 EMD65067.1 - 0.00021 21.7 0.3 0.6 10.5 0.0 3.4 4 0 0 4 4 3 1 AAA domain TsaE PF02367.17 EMD65067.1 - 0.00031 20.8 0.0 1.1 9.3 0.0 2.8 2 1 1 3 3 3 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_3 PF07726.11 EMD65067.1 - 0.00044 20.1 0.0 1.1 9.1 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) ResIII PF04851.15 EMD65067.1 - 0.00047 20.2 0.0 0.077 13.0 0.0 2.5 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_11 PF13086.6 EMD65067.1 - 0.00069 19.5 0.0 1.4 8.7 0.0 2.4 2 0 0 2 2 2 2 AAA domain DUF2075 PF09848.9 EMD65067.1 - 0.00096 18.5 0.0 1.2 8.3 0.0 2.3 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) ATPase_2 PF01637.18 EMD65067.1 - 0.0011 18.9 0.0 2.3 8.1 0.0 3.5 3 1 0 3 3 3 1 ATPase domain predominantly from Archaea AAA_30 PF13604.6 EMD65067.1 - 0.0019 18.0 0.3 1.8 8.3 0.0 2.5 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 EMD65067.1 - 0.0024 17.8 0.1 1.4 8.8 0.0 2.9 3 0 0 3 3 3 1 NACHT domain NB-ARC PF00931.22 EMD65067.1 - 0.0066 15.7 0.0 1.7 7.8 0.0 2.8 3 0 0 3 3 2 1 NB-ARC domain Viral_helicase1 PF01443.18 EMD65067.1 - 0.0092 15.7 0.0 0.68 9.6 0.0 2.5 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase Zeta_toxin PF06414.12 EMD65067.1 - 0.013 14.8 0.0 6 6.1 0.0 2.7 2 0 0 2 2 2 0 Zeta toxin AAA_19 PF13245.6 EMD65067.1 - 0.014 15.8 1.5 8.8 6.7 0.0 3.4 3 1 0 4 4 2 0 AAA domain KAP_NTPase PF07693.14 EMD65067.1 - 0.019 14.2 0.3 0.91 8.7 0.0 2.8 2 2 0 3 3 2 0 KAP family P-loop domain Sigma54_activ_2 PF14532.6 EMD65067.1 - 0.022 14.9 0.0 3.8 7.6 0.0 2.6 2 0 0 2 2 2 0 Sigma-54 interaction domain UFD1 PF03152.14 EMD65067.1 - 0.029 13.8 0.0 0.26 10.8 0.0 2.1 1 1 1 2 2 2 0 Ubiquitin fusion degradation protein UFD1 NTPase_1 PF03266.15 EMD65067.1 - 0.03 14.3 0.4 6.8 6.6 0.0 3.6 3 0 0 3 3 3 0 NTPase IPT PF01745.16 EMD65067.1 - 0.03 13.7 0.0 2.4 7.5 0.0 2.3 2 0 0 2 2 2 0 Isopentenyl transferase Zot PF05707.12 EMD65067.1 - 0.032 13.9 0.0 2 8.0 0.0 3.2 2 1 0 2 2 2 0 Zonular occludens toxin (Zot) AAA_6 PF12774.7 EMD65067.1 - 0.091 11.7 0.2 9.1 5.1 0.0 2.5 3 0 0 3 3 2 0 Hydrolytic ATP binding site of dynein motor region XPG_N PF00752.17 EMD65068.1 - 0.00013 22.4 0.0 0.00019 21.9 0.0 1.2 1 0 0 1 1 1 1 XPG N-terminal domain DIOX_N PF14226.6 EMD65069.1 - 1.1e-22 81.0 0.0 1.7e-22 80.4 0.0 1.2 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EMD65069.1 - 6.7e-16 58.6 0.0 1.8e-15 57.2 0.0 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily PTCB-BRCT PF12738.7 EMD65070.1 - 3.7e-48 161.3 0.2 1.3e-23 82.7 0.0 4.6 5 0 0 5 5 5 3 twin BRCT domain BRCT PF00533.26 EMD65070.1 - 2.3e-32 111.2 0.0 2.2e-11 44.0 0.0 5.2 5 0 0 5 5 5 3 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EMD65070.1 - 4.7e-15 55.8 0.0 0.001 19.5 0.0 5.3 5 0 0 5 5 5 4 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 EMD65070.1 - 9.3e-06 25.9 0.0 0.85 10.0 0.0 3.7 3 0 0 3 3 3 2 DNA ligase 3 BRCT domain RTT107_BRCT_5 PF16770.5 EMD65070.1 - 2.5e-05 24.1 0.0 0.077 12.9 0.0 3.5 3 1 1 4 4 4 2 Regulator of Ty1 transposition protein 107 BRCT domain BRCT_3 PF18428.1 EMD65070.1 - 9.9e-05 22.4 0.2 1.7 8.8 0.1 3.9 4 0 0 4 4 4 2 BRCA1 C Terminus (BRCT) domain Arrestin_C PF02752.22 EMD65071.1 - 1.1e-20 74.5 0.0 3.2e-20 73.0 0.0 1.9 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 EMD65071.1 - 1.4e-08 34.9 0.0 0.00014 22.0 0.0 2.5 2 0 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain Nha1_C PF08619.10 EMD65072.1 - 8.1e-106 355.0 40.2 8.1e-106 355.0 40.2 2.0 2 0 0 2 2 2 1 Alkali metal cation/H+ antiporter Nha1 C terminus Na_H_Exchanger PF00999.21 EMD65072.1 - 5.2e-76 255.9 22.9 6.2e-76 255.6 22.9 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family BBP1_N PF15271.6 EMD65072.1 - 0.14 13.0 2.2 0.81 10.5 0.5 2.8 2 0 0 2 2 2 0 Spindle pole body component BBP1, Mps2-binding protein DUF4190 PF13828.6 EMD65072.1 - 0.46 10.3 0.0 0.46 10.3 0.0 3.9 4 0 0 4 4 4 0 Domain of unknown function (DUF4190) YrhC PF14143.6 EMD65072.1 - 3.2 7.9 4.1 1.6 8.8 0.7 2.2 2 0 0 2 2 2 0 YrhC-like protein Exo_endo_phos_2 PF14529.6 EMD65073.1 - 0.17 11.8 0.3 3.8 7.4 0.1 2.2 1 1 1 2 2 2 0 Endonuclease-reverse transcriptase FANCA_interact PF15751.5 EMD65076.1 - 0.06 13.8 0.8 0.11 13.0 0.8 1.3 1 0 0 1 1 1 0 FAAP20 FANCA interaction domain Fer2_3 PF13085.6 EMD65076.1 - 0.12 12.4 0.8 0.23 11.5 0.8 1.4 1 0 0 1 1 1 0 2Fe-2S iron-sulfur cluster binding domain KRE1 PF17056.5 EMD65077.1 - 0.0058 16.3 1.2 0.0058 16.3 1.2 2.0 1 1 1 2 2 2 1 Killer toxin-resistance protein 1 Glyco_hydro_16 PF00722.21 EMD65079.1 - 4.3e-18 65.4 0.2 7.2e-18 64.7 0.2 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 GHD PF17834.1 EMD65079.1 - 0.15 12.1 0.1 0.43 10.7 0.1 1.7 1 0 0 1 1 1 0 Beta-sandwich domain in beta galactosidase RasGEF PF00617.19 EMD65080.1 - 3.7e-61 206.4 0.4 7.2e-61 205.5 0.4 1.5 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 EMD65080.1 - 5.8e-29 100.4 0.0 1.5e-28 99.1 0.0 1.8 1 0 0 1 1 1 1 RasGEF N-terminal motif SH3_1 PF00018.28 EMD65080.1 - 3.2e-15 55.5 0.1 6.5e-15 54.5 0.1 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EMD65080.1 - 2.2e-14 53.0 0.1 5.7e-14 51.7 0.1 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EMD65080.1 - 5e-12 45.3 0.1 1.1e-11 44.3 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain WW PF00397.26 EMD65080.1 - 0.00079 19.5 0.0 0.0017 18.4 0.0 1.6 1 0 0 1 1 1 1 WW domain Fungal_trans PF04082.18 EMD65081.1 - 4e-16 58.9 2.6 6e-16 58.3 2.6 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-H2C2_2 PF13465.6 EMD65081.1 - 5.4e-07 29.7 14.0 7.7e-05 22.9 5.5 2.9 2 0 0 2 2 2 2 Zinc-finger double domain zf-C2H2 PF00096.26 EMD65081.1 - 0.00099 19.4 14.3 0.04 14.4 5.3 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_3rep PF18868.1 EMD65081.1 - 0.013 16.2 0.5 0.11 13.2 0.4 2.3 1 1 1 2 2 2 0 Zinc finger C2H2-type, 3 repeats zf-C2H2_4 PF13894.6 EMD65081.1 - 0.3 12.0 19.6 0.27 12.2 4.1 3.1 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EMD65081.1 - 1.7 9.0 8.0 1.4 9.3 3.7 2.6 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Ribosomal_L7Ae PF01248.26 EMD65082.1 - 1.5e-20 72.7 4.4 1.8e-19 69.3 4.4 2.2 1 1 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Fungal_trans_2 PF11951.8 EMD65083.1 - 1.9e-07 30.2 0.2 2.9e-07 29.6 0.2 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD65083.1 - 2.7e-07 30.6 13.6 3.9e-07 30.1 13.6 1.2 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RTA1 PF04479.13 EMD65084.1 - 5.7e-63 212.3 10.7 5.7e-63 212.3 10.7 1.6 2 0 0 2 2 2 1 RTA1 like protein DUF2873 PF11395.8 EMD65084.1 - 0.054 13.4 2.9 0.21 11.5 2.9 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2873) SecY PF00344.20 EMD65085.1 - 7.8e-72 242.1 9.4 9.5e-72 241.8 9.4 1.1 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.9 EMD65085.1 - 1.9e-17 62.8 0.2 5e-17 61.4 0.2 1.8 1 0 0 1 1 1 1 Plug domain of Sec61p DUF2929 PF11151.8 EMD65085.1 - 0.29 11.5 4.7 0.16 12.3 1.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2929) LIM PF00412.22 EMD65086.1 - 1.6e-18 66.7 20.2 2.5e-10 40.4 3.4 2.5 3 0 0 3 3 3 2 LIM domain WRC PF08879.10 EMD65086.1 - 0.0018 17.9 0.4 0.64 9.8 0.1 2.5 2 0 0 2 2 2 2 WRC DUF2321 PF10083.9 EMD65086.1 - 1.8 8.2 7.3 0.16 11.6 0.6 2.1 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2321) CD99L2 PF12301.8 EMD65086.1 - 2.5 8.4 4.3 0.67 10.2 0.6 1.9 2 0 0 2 2 2 0 CD99 antigen like protein 2 NAD_binding_5 PF07994.12 EMD65087.1 - 1.1e-145 485.1 0.1 1.3e-145 484.8 0.1 1.1 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase Inos-1-P_synth PF01658.17 EMD65087.1 - 7e-45 151.8 0.8 1.4e-44 150.8 0.5 1.7 2 0 0 2 2 2 1 Myo-inositol-1-phosphate synthase tRNA_anti-codon PF01336.25 EMD65088.1 - 0.048 13.7 0.0 0.1 12.6 0.0 1.5 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain MIS13 PF08202.11 EMD65089.1 - 2.9e-48 164.7 0.1 6.4e-48 163.6 0.0 1.6 2 0 0 2 2 2 1 Mis12-Mtw1 protein family ABC_tran_CTD PF16326.5 EMD65089.1 - 0.05 13.8 4.2 0.15 12.4 4.2 1.8 1 0 0 1 1 1 0 ABC transporter C-terminal domain PS_Dcarbxylase PF02666.15 EMD65090.1 - 1.6e-56 191.0 0.0 2.4e-56 190.5 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase C2 PF00168.30 EMD65090.1 - 6.5e-41 138.8 0.1 1.5e-19 70.2 0.1 2.5 2 0 0 2 2 2 2 C2 domain YL1 PF05764.13 EMD65090.1 - 0.00099 19.3 2.8 0.0019 18.4 2.8 1.4 1 0 0 1 1 1 1 YL1 nuclear protein EF-hand_7 PF13499.6 EMD65090.1 - 0.0024 18.3 2.1 0.0068 16.8 0.1 2.5 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 EMD65090.1 - 0.033 13.7 0.0 0.11 12.1 0.0 2.0 1 0 0 1 1 1 0 EF hand CDC45 PF02724.14 EMD65090.1 - 0.12 10.6 3.2 0.19 10.0 3.2 1.2 1 0 0 1 1 1 0 CDC45-like protein EF-hand_6 PF13405.6 EMD65090.1 - 0.14 12.2 0.4 0.81 9.8 0.0 2.5 2 0 0 2 2 2 0 EF-hand domain PBP1_TM PF14812.6 EMD65090.1 - 2 8.9 6.8 5.9 7.3 6.8 1.8 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal G-alpha PF00503.20 EMD65092.1 - 6.6e-122 407.1 2.1 7.6e-122 406.9 2.1 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EMD65092.1 - 4.5e-15 55.5 2.5 2.4e-10 40.1 0.1 2.6 2 0 0 2 2 2 2 ADP-ribosylation factor family zf-CHC2 PF01807.20 EMD65092.1 - 0.0004 20.2 0.0 0.0018 18.1 0.0 2.0 2 0 0 2 2 2 1 CHC2 zinc finger Gtr1_RagA PF04670.12 EMD65092.1 - 0.0036 16.7 4.1 0.085 12.2 0.1 2.7 2 1 1 3 3 3 2 Gtr1/RagA G protein conserved region AAA_29 PF13555.6 EMD65092.1 - 0.02 14.6 0.0 0.05 13.4 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain Roc PF08477.13 EMD65092.1 - 0.021 15.0 0.2 2.4 8.4 0.0 2.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase NB-ARC PF00931.22 EMD65092.1 - 0.062 12.5 0.1 0.1 11.7 0.1 1.3 1 0 0 1 1 1 0 NB-ARC domain GTP_EFTU PF00009.27 EMD65092.1 - 0.083 12.4 0.0 1.4 8.4 0.0 2.3 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EMD65092.1 - 0.14 12.3 0.1 8.8 6.4 0.0 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase FtsK_SpoIIIE PF01580.18 EMD65092.1 - 0.14 11.4 0.0 0.35 10.2 0.0 1.6 1 0 0 1 1 1 0 FtsK/SpoIIIE family DDE_Tnp_IS240 PF13610.6 EMD65095.1 - 0.21 11.8 0.0 0.38 11.0 0.0 1.3 1 0 0 1 1 1 0 DDE domain Transketolase_N PF00456.21 EMD65096.1 - 2.6e-152 506.6 0.1 3.4e-152 506.2 0.1 1.1 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.24 EMD65096.1 - 5.3e-44 150.0 0.0 9.1e-44 149.2 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 EMD65096.1 - 4.5e-13 49.2 0.0 1.2e-12 47.8 0.0 1.8 1 1 0 1 1 1 1 Transketolase, C-terminal domain E1_dh PF00676.20 EMD65096.1 - 0.00018 20.5 0.1 0.00029 19.9 0.1 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.6 EMD65096.1 - 0.00049 19.4 0.0 0.0009 18.5 0.0 1.4 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase Beta_elim_lyase PF01212.21 EMD65096.1 - 0.018 14.4 0.0 0.03 13.6 0.0 1.3 1 0 0 1 1 1 0 Beta-eliminating lyase GST_N_4 PF17172.4 EMD65097.1 - 4.6e-23 81.8 0.1 1.3e-22 80.3 0.1 1.8 2 0 0 2 2 2 1 Glutathione S-transferase N-terminal domain GST_C_6 PF17171.4 EMD65097.1 - 2.8e-15 55.8 0.0 5.2e-15 55.0 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Tom37 PF10568.9 EMD65097.1 - 2.2e-10 40.9 0.1 3.8e-10 40.1 0.1 1.4 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein SAM35 PF10806.8 EMD65097.1 - 4.4e-06 27.0 0.4 9.7e-06 25.9 0.3 1.6 1 1 0 1 1 1 1 SAM35, subunit of SAM coomplex GST_C_2 PF13410.6 EMD65097.1 - 0.00021 21.3 1.2 0.00043 20.3 1.1 1.6 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain TraF PF13728.6 EMD65097.1 - 0.078 12.8 0.1 0.1 12.4 0.1 1.2 1 0 0 1 1 1 0 F plasmid transfer operon protein Methyltransf_25 PF13649.6 EMD65098.1 - 4e-13 49.9 0.0 7.4e-13 49.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMD65098.1 - 2.2e-11 43.8 0.0 3.1e-11 43.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EMD65098.1 - 5.8e-10 39.2 0.0 1.1e-09 38.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMD65098.1 - 2.1e-08 34.8 0.0 5.1e-08 33.6 0.0 1.7 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMD65098.1 - 7.2e-08 33.0 0.0 1.4e-07 32.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EMD65098.1 - 2.2e-05 23.9 0.0 3.9e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family PCMT PF01135.19 EMD65098.1 - 0.0033 17.2 0.0 0.013 15.3 0.0 1.8 2 0 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_7 PF03492.15 EMD65098.1 - 0.0046 16.2 0.0 0.0077 15.5 0.0 1.3 1 0 0 1 1 1 1 SAM dependent carboxyl methyltransferase CheR PF01739.18 EMD65098.1 - 0.0084 15.6 0.0 0.014 14.9 0.0 1.2 1 0 0 1 1 1 1 CheR methyltransferase, SAM binding domain Methyltransf_33 PF10017.9 EMD65098.1 - 0.083 12.0 0.0 0.12 11.5 0.0 1.2 1 0 0 1 1 1 0 Histidine-specific methyltransferase, SAM-dependent TehB PF03848.14 EMD65098.1 - 0.1 12.0 0.0 0.2 11.0 0.0 1.4 1 0 0 1 1 1 0 Tellurite resistance protein TehB Methyltransf_32 PF13679.6 EMD65098.1 - 0.24 11.4 0.1 1 9.3 0.0 1.9 1 1 1 2 2 2 0 Methyltransferase domain DUF1264 PF06884.11 EMD65099.1 - 3.1e-75 251.5 0.0 3.7e-75 251.2 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1264) DUF4598 PF15370.6 EMD65100.1 - 5e-22 78.5 13.0 6.9e-22 78.0 1.5 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF4598) L51_S25_CI-B8 PF05047.16 EMD65100.1 - 0.19 11.7 0.0 0.37 10.7 0.0 1.5 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain BUD22 PF09073.10 EMD65100.1 - 0.35 10.1 15.2 0.45 9.8 15.2 1.1 1 0 0 1 1 1 0 BUD22 BSP_II PF05432.11 EMD65100.1 - 0.47 10.1 16.7 0.66 9.6 16.7 1.2 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) GOLD_2 PF13897.6 EMD65100.1 - 0.57 10.7 4.1 20 5.7 2.1 2.2 2 0 0 2 2 2 0 Golgi-dynamics membrane-trafficking FAM176 PF14851.6 EMD65100.1 - 2.9 7.5 11.8 1.4 8.6 4.5 2.3 2 0 0 2 2 2 0 FAM176 family DUF3449 PF11931.8 EMD65100.1 - 7.3 6.3 7.5 9.9 5.9 1.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3449) IF4E PF01652.18 EMD65101.1 - 1.2e-33 116.1 0.6 1.5e-33 115.8 0.6 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E Band_7 PF01145.25 EMD65102.1 - 1.6e-24 86.9 7.7 3.1e-24 85.9 7.7 1.5 1 1 0 1 1 1 1 SPFH domain / Band 7 family YdfA_immunity PF12127.8 EMD65102.1 - 0.00012 21.3 3.7 0.00017 20.7 3.7 1.2 1 0 0 1 1 1 1 SigmaW regulon antibacterial GatB_Yqey PF02637.18 EMD65102.1 - 0.014 15.3 2.2 0.024 14.5 2.1 1.5 1 1 0 1 1 1 0 GatB domain zf-C2H2_aberr PF17017.5 EMD65103.1 - 0.00069 19.8 0.9 0.0013 18.9 0.0 1.8 2 0 0 2 2 2 1 Aberrant zinc-finger zf-C2H2 PF00096.26 EMD65103.1 - 0.0013 19.1 11.5 0.21 12.1 0.1 3.9 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMD65103.1 - 0.36 11.8 10.7 12 7.1 2.9 3.9 3 0 0 3 3 3 0 C2H2-type zinc finger CENP-R PF06729.12 EMD65103.1 - 0.82 9.6 6.5 0.042 13.8 0.7 1.7 2 0 0 2 2 2 0 Kinetochore component, CENP-R GMC_oxred_N PF00732.19 EMD65105.1 - 1.6e-47 162.3 0.0 2.3e-47 161.8 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EMD65105.1 - 1.6e-30 106.5 0.2 3.6e-30 105.4 0.2 1.6 1 0 0 1 1 1 1 GMC oxidoreductase DAO PF01266.24 EMD65105.1 - 1.7e-05 24.6 0.1 0.00022 20.9 0.0 2.6 3 0 0 3 3 3 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EMD65105.1 - 0.00011 21.4 0.0 0.061 12.4 0.1 2.5 2 0 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 EMD65105.1 - 0.00086 19.5 0.4 0.00086 19.5 0.4 2.4 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 EMD65105.1 - 0.008 15.3 0.0 0.019 14.0 0.0 1.6 1 0 0 1 1 1 1 Lycopene cyclase protein Trp_halogenase PF04820.14 EMD65105.1 - 0.057 12.3 0.0 0.086 11.7 0.0 1.2 1 0 0 1 1 1 0 Tryptophan halogenase Pyr_redox_2 PF07992.14 EMD65105.1 - 0.068 12.4 0.0 0.12 11.6 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EMD65105.1 - 0.11 11.8 0.0 0.48 9.6 0.1 1.8 2 0 0 2 2 2 0 Thi4 family DUF2616 PF11077.8 EMD65106.1 - 0.071 12.8 0.1 0.078 12.7 0.1 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2616) Ring_hydroxyl_A PF00848.19 EMD65109.1 - 7.5e-22 78.3 3.7 2e-12 47.6 1.1 2.3 1 1 1 2 2 2 2 Ring hydroxylating alpha subunit (catalytic domain) Rieske PF00355.26 EMD65109.1 - 7.4e-17 61.1 0.0 1.5e-16 60.1 0.0 1.5 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain GCV_T PF01571.21 EMD65110.1 - 3.7e-70 236.2 0.0 1.2e-69 234.6 0.0 1.8 2 0 0 2 2 2 1 Aminomethyltransferase folate-binding domain DAO PF01266.24 EMD65110.1 - 6.5e-48 164.1 0.2 1.1e-47 163.4 0.2 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase HAGH_C PF16123.5 EMD65110.1 - 1.1e-19 70.7 0.1 2.3e-19 69.7 0.1 1.5 1 0 0 1 1 1 1 Hydroxyacylglutathione hydrolase C-terminus GCV_T_C PF08669.11 EMD65110.1 - 2e-19 69.3 0.0 4.8e-19 68.1 0.0 1.7 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain FAO_M PF16350.5 EMD65110.1 - 9.9e-17 61.0 0.0 2e-16 60.0 0.0 1.6 1 0 0 1 1 1 1 FAD dependent oxidoreductase central domain Lactamase_B PF00753.27 EMD65110.1 - 4.4e-15 56.2 1.8 9.3e-14 51.9 1.8 2.4 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Pyr_redox_2 PF07992.14 EMD65110.1 - 2.6e-07 30.2 0.4 0.016 14.5 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EMD65110.1 - 3.4e-06 27.5 0.2 0.0075 16.8 0.0 2.8 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EMD65110.1 - 0.00015 20.8 0.3 0.0016 17.4 0.0 2.1 2 0 0 2 2 2 1 Tryptophan halogenase SoxG PF04268.12 EMD65110.1 - 0.00062 19.9 0.0 0.16 12.1 0.0 3.5 3 1 0 3 3 3 1 Sarcosine oxidase, gamma subunit family NAD_binding_9 PF13454.6 EMD65110.1 - 0.0011 19.0 0.2 1.4 8.9 0.0 2.7 2 0 0 2 2 2 2 FAD-NAD(P)-binding TrkA_N PF02254.18 EMD65110.1 - 0.0023 18.1 0.0 0.0068 16.7 0.0 1.8 1 0 0 1 1 1 1 TrkA-N domain Shikimate_DH PF01488.20 EMD65110.1 - 0.0059 16.7 0.1 0.011 15.8 0.1 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase FAD_binding_3 PF01494.19 EMD65110.1 - 0.012 14.9 0.5 0.087 12.1 0.5 2.1 1 1 0 1 1 1 0 FAD binding domain ThiF PF00899.21 EMD65110.1 - 0.025 14.0 0.1 0.043 13.2 0.1 1.3 1 0 0 1 1 1 0 ThiF family FAD_binding_2 PF00890.24 EMD65110.1 - 0.036 13.1 0.1 0.087 11.9 0.1 1.6 1 1 0 1 1 1 0 FAD binding domain NAD_binding_8 PF13450.6 EMD65110.1 - 0.084 13.1 0.0 0.33 11.2 0.0 2.1 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 EMD65110.1 - 0.12 11.5 0.0 3.3 6.9 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase IF-2B PF01008.17 EMD65111.1 - 4.7e-74 249.1 0.1 5.9e-74 248.8 0.1 1.1 1 0 0 1 1 1 1 Initiation factor 2 subunit family TrkA_C PF02080.21 EMD65111.1 - 0.06 13.2 0.1 0.15 12.0 0.1 1.6 1 0 0 1 1 1 0 TrkA-C domain Presenilin PF01080.17 EMD65111.1 - 5.6 5.6 6.1 8.2 5.1 6.1 1.2 1 0 0 1 1 1 0 Presenilin RCC1_2 PF13540.6 EMD65112.1 - 7.4e-14 51.1 16.4 4.1e-07 29.6 0.2 6.8 7 0 0 7 7 7 3 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EMD65112.1 - 5.9e-06 26.8 11.8 0.0015 19.1 0.6 5.0 7 1 0 7 7 7 2 Regulator of chromosome condensation (RCC1) repeat F-box-like PF12937.7 EMD65112.1 - 3.9e-05 23.5 0.7 7.4e-05 22.6 0.7 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EMD65112.1 - 0.002 17.9 1.1 0.0032 17.3 0.2 1.7 2 0 0 2 2 2 1 F-box domain HET PF06985.11 EMD65113.1 - 3.4e-15 56.7 0.1 6.8e-15 55.7 0.1 1.5 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Hom_end_hint PF05203.16 EMD65113.1 - 0.093 12.7 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 Hom_end-associated Hint MMU163 PF17119.5 EMD65115.1 - 0.024 13.8 0.6 0.033 13.4 0.6 1.2 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis DUF5094 PF17015.5 EMD65115.1 - 1.1 9.3 4.0 1.6 8.8 4.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5094) UQ_con PF00179.26 EMD65116.1 - 5.3e-39 133.1 0.0 6.3e-39 132.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UFC1 PF08694.11 EMD65116.1 - 0.052 13.2 0.2 0.077 12.6 0.2 1.5 1 1 0 1 1 1 0 Ubiquitin-fold modifier-conjugating enzyme 1 Prok-E2_B PF14461.6 EMD65116.1 - 0.093 12.4 0.0 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 Prokaryotic E2 family B RNase_PH PF01138.21 EMD65117.1 - 1.5e-11 45.0 0.1 2.4e-11 44.3 0.1 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 EMD65117.1 - 0.14 12.2 0.0 0.24 11.5 0.0 1.4 1 0 0 1 1 1 0 3' exoribonuclease family, domain 2 SMP_LBD PF17047.5 EMD65118.1 - 0.012 15.1 0.0 0.02 14.3 0.0 1.3 1 0 0 1 1 1 0 Synaptotagmin-like mitochondrial-lipid-binding domain A_deaminase PF00962.22 EMD65119.1 - 6.2e-25 88.2 0.0 2.9e-23 82.7 0.0 2.2 2 0 0 2 2 2 2 Adenosine/AMP deaminase GATase_4 PF13230.6 EMD65120.1 - 3.8e-16 58.8 0.0 1.5e-14 53.6 0.0 2.1 2 0 0 2 2 2 2 Glutamine amidotransferases class-II GATase_6 PF13522.6 EMD65120.1 - 3.3e-09 37.0 0.0 6.4e-09 36.1 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain Arm PF00514.23 EMD65121.1 - 3e-98 319.2 14.3 9e-14 51.0 0.2 8.4 8 0 0 8 8 8 8 Armadillo/beta-catenin-like repeat IBB PF01749.20 EMD65121.1 - 4.7e-26 91.0 1.8 4.7e-26 91.0 1.8 2.0 2 0 0 2 2 2 1 Importin beta binding domain Arm_3 PF16186.5 EMD65121.1 - 1.4e-22 79.0 4.7 3.6e-22 77.7 4.7 1.7 1 0 0 1 1 1 1 Atypical Arm repeat HEAT_EZ PF13513.6 EMD65121.1 - 3.4e-22 78.5 7.1 1.8e-08 34.7 0.1 6.6 5 1 1 6 6 6 5 HEAT-like repeat HEAT_2 PF13646.6 EMD65121.1 - 2.8e-20 72.5 2.7 2.4e-09 37.5 0.1 5.7 2 1 3 5 5 5 3 HEAT repeats HEAT PF02985.22 EMD65121.1 - 7.9e-19 66.1 2.2 1.8e-05 24.6 0.0 7.2 8 0 0 8 8 8 4 HEAT repeat Arm_2 PF04826.13 EMD65121.1 - 8.4e-09 35.3 0.0 0.087 12.3 0.0 4.1 2 1 2 4 4 4 3 Armadillo-like Adaptin_N PF01602.20 EMD65121.1 - 2.4e-06 26.4 0.0 7.5e-05 21.5 0.0 2.5 1 1 1 2 2 2 1 Adaptin N terminal region V-ATPase_H_C PF11698.8 EMD65121.1 - 2.1e-05 24.6 0.0 1.6 8.9 0.0 4.7 3 2 2 5 5 5 2 V-ATPase subunit H Cnd1 PF12717.7 EMD65121.1 - 0.00013 22.1 0.0 0.21 11.6 0.0 3.2 2 1 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT_PBS PF03130.16 EMD65121.1 - 0.0046 17.5 6.5 0.66 10.8 0.3 5.0 5 0 0 5 5 5 1 PBS lyase HEAT-like repeat NopRA1 PF16201.5 EMD65121.1 - 0.0058 16.2 0.0 9.8 5.7 0.0 3.9 1 1 2 4 4 4 1 Nucleolar pre-ribosomal-associated protein 1 RICTOR_V PF14668.6 EMD65121.1 - 0.024 14.9 5.9 2.4 8.4 0.1 4.9 3 2 3 6 6 6 0 Rapamycin-insensitive companion of mTOR, domain 5 Glycos_trans_3N PF02885.17 EMD65121.1 - 0.034 14.0 0.0 33 4.4 0.0 3.5 3 0 0 3 3 3 0 Glycosyl transferase family, helical bundle domain POT1PC PF16686.5 EMD65122.1 - 3.8e-36 124.3 0.6 8.3e-36 123.2 0.6 1.6 1 0 0 1 1 1 1 ssDNA-binding domain of telomere protection protein POT1 PF02765.17 EMD65122.1 - 2e-07 30.9 0.0 4.9e-07 29.7 0.0 1.7 1 0 0 1 1 1 1 Telomeric single stranded DNA binding POT1/CDC13 U1snRNP70_N PF12220.8 EMD65122.1 - 0.081 13.6 7.7 0.22 12.2 7.7 1.7 1 0 0 1 1 1 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF501 PF04417.12 EMD65122.1 - 0.24 11.2 1.7 0.45 10.3 1.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF501) DUF4337 PF14235.6 EMD65122.1 - 0.75 9.9 7.5 1.7 8.7 7.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) EMP24_GP25L PF01105.24 EMD65122.1 - 0.89 9.5 4.4 2.8 7.9 4.4 1.8 1 1 0 1 1 1 0 emp24/gp25L/p24 family/GOLD DUF543 PF04418.12 EMD65124.1 - 1.4e-29 101.9 0.0 1.6e-29 101.7 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF543) Urb2 PF10441.9 EMD65125.1 - 1.3e-48 165.6 0.0 7.8e-48 163.1 0.0 2.4 2 0 0 2 2 2 1 Urb2/Npa2 family DUF1722 PF08349.11 EMD65125.1 - 0.13 12.6 0.7 6 7.2 0.5 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF1722) PHD PF00628.29 EMD65126.1 - 1.4e-09 37.7 6.5 1.6e-09 37.5 6.5 1.1 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 EMD65126.1 - 0.00018 21.0 0.8 0.00026 20.5 0.8 1.3 1 0 0 1 1 1 1 PHD-finger Capsid_VP7 PF17071.5 EMD65126.1 - 0.2 10.9 0.8 0.21 10.8 0.8 1.0 1 0 0 1 1 1 0 Outer capsid protein VP7 Fe-ADH PF00465.19 EMD65128.1 - 3.2e-55 187.4 0.1 4.2e-55 187.0 0.1 1.0 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 EMD65128.1 - 1.2e-08 35.0 0.2 0.0009 19.0 0.0 2.3 2 0 0 2 2 2 2 Iron-containing alcohol dehydrogenase GCV_H PF01597.19 EMD65129.1 - 1.7e-34 118.3 1.3 2.2e-34 118.0 1.3 1.1 1 0 0 1 1 1 1 Glycine cleavage H-protein Biotin_lipoyl PF00364.22 EMD65129.1 - 0.064 13.1 0.5 0.13 12.1 0.5 1.6 1 0 0 1 1 1 0 Biotin-requiring enzyme Ribosomal_S6 PF01250.17 EMD65130.1 - 1.1e-23 83.4 0.0 1.2e-23 83.1 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S6 ArAE_2_N PF10337.9 EMD65134.1 - 1.2e-48 166.4 29.8 1.2e-36 126.8 0.8 5.1 3 1 1 4 4 4 3 Putative ER transporter, 6TM, N-terminal FUSC_2 PF13515.6 EMD65134.1 - 2.1e-14 53.8 19.2 2.1e-14 53.8 19.2 2.7 2 0 0 2 2 2 1 Fusaric acid resistance protein-like ArAE_2 PF10334.9 EMD65134.1 - 7.6e-12 45.5 0.0 4e-10 39.9 0.0 2.6 1 1 0 1 1 1 1 Aromatic acid exporter family member 2 CytB6-F_Fe-S PF08802.10 EMD65134.1 - 0.091 12.8 2.7 0.75 9.9 0.0 3.6 3 0 0 3 3 3 0 Cytochrome B6-F complex Fe-S subunit DUF1422 PF07226.11 EMD65134.1 - 0.14 12.2 2.1 1.1 9.3 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1422) Utp8 PF10395.9 EMD65135.1 - 6.6e-09 34.8 0.3 2.1e-07 29.9 0.0 3.0 3 1 0 3 3 3 2 Utp8 family Rad17 PF03215.15 EMD65136.1 - 2.7e-08 34.0 0.2 1.1e-06 28.7 0.0 2.9 3 0 0 3 3 3 1 Rad17 P-loop domain AAA PF00004.29 EMD65136.1 - 7.3e-08 32.9 0.0 6.7e-06 26.6 0.0 2.4 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EMD65136.1 - 0.00041 20.8 0.2 0.002 18.5 0.2 2.2 1 1 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.6 EMD65136.1 - 0.0039 17.7 0.1 0.018 15.6 0.0 2.3 2 1 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EMD65136.1 - 0.0083 16.4 0.2 0.16 12.3 0.2 2.6 1 1 0 1 1 1 1 AAA domain NTPase_1 PF03266.15 EMD65136.1 - 0.031 14.2 0.0 0.51 10.2 0.0 2.3 2 0 0 2 2 2 0 NTPase Zeta_toxin PF06414.12 EMD65136.1 - 0.063 12.6 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin DUF815 PF05673.13 EMD65136.1 - 0.1 11.7 0.0 0.21 10.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_29 PF13555.6 EMD65136.1 - 0.12 12.2 0.0 0.26 11.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain IstB_IS21 PF01695.17 EMD65136.1 - 0.16 11.7 0.0 0.36 10.6 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein UCH PF00443.29 EMD65137.1 - 3e-35 122.0 0.2 8.4e-35 120.5 0.2 1.8 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EMD65137.1 - 4.5e-06 26.5 1.4 1.7e-05 24.6 1.4 2.0 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DUF4211 PF13926.6 EMD65137.1 - 0.07 13.2 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4211) Alb1 PF09135.11 EMD65138.1 - 1e-25 90.6 8.8 1.7e-25 89.9 8.8 1.4 1 0 0 1 1 1 1 Alb1 DUF4211 PF13926.6 EMD65139.1 - 1.4e-36 125.7 0.0 1.4e-36 125.7 0.0 2.5 2 1 0 2 2 2 1 Domain of unknown function (DUF4211) AF-4 PF05110.13 EMD65139.1 - 0.0004 18.6 4.5 0.0004 18.6 4.5 2.1 2 0 0 2 2 2 1 AF-4 proto-oncoprotein PalH PF08733.10 EMD65140.1 - 1e-113 379.7 0.0 1.2e-113 379.4 0.0 1.1 1 0 0 1 1 1 1 PalH/RIM21 PX PF00787.24 EMD65141.1 - 2.5e-16 59.6 0.1 8.3e-16 58.0 0.1 1.9 1 0 0 1 1 1 1 PX domain V-SNARE_C PF12352.8 EMD65141.1 - 0.0032 17.7 0.1 0.0065 16.7 0.1 1.5 1 0 0 1 1 1 1 Snare region anchored in the vesicle membrane C-terminus Prefoldin_3 PF13758.6 EMD65141.1 - 0.063 13.3 1.3 0.16 12.0 0.0 2.2 2 0 0 2 2 2 0 Prefoldin subunit DUF3552 PF12072.8 EMD65141.1 - 1.1 8.6 8.5 1.8 7.9 8.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) Ribosomal_S14 PF00253.21 EMD65142.1 - 7.4e-15 54.5 2.1 8.9e-15 54.2 2.1 1.1 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e STAG PF08514.11 EMD65143.1 - 5.3e-31 106.9 0.0 5.3e-31 106.9 0.0 3.1 3 0 0 3 3 3 1 STAG domain HEAT_2 PF13646.6 EMD65143.1 - 3.8e-06 27.2 3.0 1.7e-05 25.1 0.1 3.5 3 1 0 3 3 3 1 HEAT repeats DUF4254 PF14063.6 EMD65143.1 - 0.0016 18.2 0.7 0.008 16.0 0.7 2.2 1 0 0 1 1 1 1 Protein of unknown function (DUF4254) HEAT PF02985.22 EMD65143.1 - 0.0033 17.6 0.1 6.9 7.2 0.1 5.0 4 0 0 4 4 4 1 HEAT repeat BLOC1_2 PF10046.9 EMD65143.1 - 0.066 13.5 0.4 0.29 11.5 0.4 2.1 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Cob_adeno_trans PF01923.18 EMD65143.1 - 0.15 12.2 0.1 0.15 12.2 0.1 3.0 4 0 0 4 4 4 0 Cobalamin adenosyltransferase Cullin PF00888.22 EMD65144.1 - 3.7e-180 600.6 8.3 4.5e-180 600.3 8.3 1.1 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 EMD65144.1 - 1.4e-21 76.3 0.3 3.2e-21 75.1 0.3 1.7 1 0 0 1 1 1 1 Cullin protein neddylation domain HbrB PF08539.11 EMD65144.1 - 0.044 13.8 0.1 0.12 12.4 0.1 1.8 1 0 0 1 1 1 0 HbrB-like DUF2070 PF09843.9 EMD65146.1 - 0.28 9.4 9.4 0.31 9.3 9.4 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) DUF959 PF06121.14 EMD65147.1 - 0.11 12.8 3.7 0.18 12.1 3.7 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF959) Ribosomal_L32e PF01655.18 EMD65148.1 - 8.5e-48 161.3 0.8 2e-47 160.1 0.8 1.7 1 0 0 1 1 1 1 Ribosomal protein L32 Cullin_binding PF03556.15 EMD65148.1 - 2.2e-32 112.0 8.3 3.7e-32 111.3 8.3 1.4 1 0 0 1 1 1 1 Cullin binding UBA_4 PF14555.6 EMD65149.1 - 1.3e-09 37.7 0.3 2.6e-09 36.7 0.3 1.5 1 0 0 1 1 1 1 UBA-like domain TAP_C PF03943.13 EMD65149.1 - 0.0062 16.1 0.2 0.011 15.4 0.2 1.4 1 0 0 1 1 1 1 TAP C-terminal domain Pol_alpha_B_N PF08418.10 EMD65150.1 - 3e-72 243.6 0.1 4.7e-72 242.9 0.1 1.3 1 0 0 1 1 1 1 DNA polymerase alpha subunit B N-terminal DNA_pol_E_B PF04042.16 EMD65150.1 - 7.8e-35 120.1 0.1 1.8e-34 119.0 0.1 1.6 1 1 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B MRNIP PF15749.5 EMD65150.1 - 0.077 13.7 0.2 0.17 12.6 0.0 1.6 2 0 0 2 2 2 0 MRN-interacting protein Frankia_peptide PF14407.6 EMD65150.1 - 0.092 12.7 0.1 29 4.8 0.1 2.9 2 0 0 2 2 2 0 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349. CRAL_TRIO PF00650.20 EMD65151.1 - 2.1e-38 131.5 0.0 2.7e-38 131.2 0.0 1.1 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EMD65151.1 - 2.1e-15 56.6 0.4 4e-15 55.7 0.4 1.4 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 EMD65151.1 - 0.00036 20.7 0.0 0.00054 20.1 0.0 1.2 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain DUF1769 PF08588.10 EMD65151.1 - 0.011 15.9 0.0 0.029 14.6 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1769) HTH_8 PF02954.19 EMD65151.1 - 0.023 14.5 0.1 0.046 13.5 0.1 1.4 1 0 0 1 1 1 0 Bacterial regulatory protein, Fis family Peptidase_C37 PF05416.12 EMD65152.1 - 0.0036 15.9 5.3 0.0063 15.1 5.3 1.3 1 0 0 1 1 1 1 Southampton virus-type processing peptidase HTH_5 PF01022.20 EMD65153.1 - 0.12 12.3 0.0 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family LexA_DNA_bind PF01726.16 EMD65153.1 - 0.2 11.5 0.1 0.89 9.4 0.0 2.0 2 0 0 2 2 2 0 LexA DNA binding domain Dynamin_N PF00350.23 EMD65154.1 - 3.3e-42 144.4 0.0 6e-42 143.5 0.0 1.5 1 0 0 1 1 1 1 Dynamin family Dynamin_M PF01031.20 EMD65154.1 - 8.2e-13 48.2 0.3 3.8e-12 46.0 0.3 1.9 1 1 0 1 1 1 1 Dynamin central region MMR_HSR1 PF01926.23 EMD65154.1 - 1.7e-05 24.9 0.0 7.1e-05 22.9 0.0 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 EMD65154.1 - 0.054 13.9 0.8 0.23 11.8 0.1 2.4 2 1 0 2 2 2 0 AAA ATPase domain AAA_21 PF13304.6 EMD65154.1 - 0.066 13.0 0.0 0.16 11.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 EMD65154.1 - 0.2 11.3 0.1 0.2 11.3 0.1 2.2 3 0 0 3 3 3 0 AAA ATPase domain UreD PF01774.17 EMD65155.1 - 6.4e-74 248.5 0.0 7.6e-74 248.2 0.0 1.1 1 0 0 1 1 1 1 UreD urease accessory protein NDUF_B8 PF05821.11 EMD65155.1 - 0.09 12.6 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8) Peptidase_S41 PF03572.18 EMD65156.1 - 5.4e-08 32.6 0.0 2.5e-07 30.4 0.0 2.0 1 1 0 1 1 1 1 Peptidase family S41 AAA_16 PF13191.6 EMD65157.1 - 4e-07 30.6 0.5 1.3e-06 28.9 0.1 2.0 2 0 0 2 2 2 1 AAA ATPase domain NACHT PF05729.12 EMD65157.1 - 8.9e-06 25.7 0.0 2e-05 24.6 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA PF00004.29 EMD65157.1 - 0.0004 20.8 0.0 0.0012 19.3 0.0 1.7 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EMD65157.1 - 0.0012 19.1 0.0 0.0046 17.2 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.6 EMD65157.1 - 0.0023 18.3 0.0 0.3 11.5 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 EMD65157.1 - 0.014 15.7 0.0 0.048 14.0 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 EMD65157.1 - 0.018 15.6 0.0 0.049 14.2 0.0 1.8 1 1 0 1 1 1 0 AAA domain RuvB_N PF05496.12 EMD65157.1 - 0.044 13.5 0.0 0.13 12.0 0.0 1.8 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 EMD65157.1 - 0.057 13.6 0.0 0.11 12.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 EMD65157.1 - 0.088 12.8 0.0 0.17 11.9 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE KAP_NTPase PF07693.14 EMD65157.1 - 0.091 12.0 0.4 4.8 6.3 0.1 2.2 1 1 0 2 2 2 0 KAP family P-loop domain Zeta_toxin PF06414.12 EMD65157.1 - 0.16 11.3 0.0 0.39 9.9 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin ABC_tran PF00005.27 EMD65157.1 - 0.16 12.4 0.0 0.34 11.4 0.0 1.6 1 1 0 1 1 1 0 ABC transporter ZZ PF00569.17 EMD65157.1 - 0.52 10.2 7.7 1.2 9.0 7.7 1.6 1 1 0 1 1 1 0 Zinc finger, ZZ type HET PF06985.11 EMD65158.1 - 2.1e-24 86.5 0.1 5.2e-24 85.2 0.1 1.7 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Terpene_synth_C PF03936.16 EMD65160.1 - 4.1e-05 23.1 0.0 5.3e-05 22.7 0.0 1.1 1 0 0 1 1 1 1 Terpene synthase family, metal binding domain DUF2236 PF09995.9 EMD65161.1 - 2e-28 100.2 0.0 3e-28 99.6 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2236) B-block_TFIIIC PF04182.12 EMD65163.1 - 3.6e-16 59.1 0.1 1.1e-15 57.6 0.0 1.9 2 0 0 2 2 2 1 B-block binding subunit of TFIIIC Acetyltransf_7 PF13508.7 EMD65165.1 - 3.1e-09 37.1 0.0 1.5e-08 35.0 0.0 1.9 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EMD65165.1 - 2.3e-08 34.0 0.0 4.2e-08 33.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EMD65165.1 - 5.5e-08 33.1 0.0 1.6e-07 31.5 0.0 1.8 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_9 PF13527.7 EMD65165.1 - 1.4e-05 25.1 0.0 0.0026 17.8 0.0 2.2 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EMD65165.1 - 0.001 19.1 0.0 0.0016 18.5 0.0 1.3 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase DUF4575 PF15143.6 EMD65166.1 - 0.025 14.8 0.4 0.03 14.5 0.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4575) CENP-B_dimeris PF09026.10 EMD65167.1 - 2.2 8.7 7.4 1.3 9.4 1.9 2.3 2 0 0 2 2 2 0 Centromere protein B dimerisation domain DUF4611 PF15387.6 EMD65167.1 - 5.6 7.2 11.1 4.7 7.5 0.1 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4611) Las1 PF04031.13 EMD65168.1 - 2.6e-44 151.0 3.2 6e-44 149.9 3.2 1.6 1 0 0 1 1 1 1 Las1-like Mito_carr PF00153.27 EMD65169.1 - 2e-53 178.3 3.9 1.2e-18 66.8 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein WD40 PF00400.32 EMD65170.1 - 5.8e-16 58.6 6.0 2.6e-06 28.1 0.5 5.8 5 1 1 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD65170.1 - 2.4e-07 31.0 0.1 0.0094 16.2 0.0 4.2 4 1 2 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain OHCU_decarbox PF09349.10 EMD65173.1 - 1.1e-46 159.2 0.1 1.2e-46 159.0 0.1 1.0 1 0 0 1 1 1 1 OHCU decarboxylase DUF678 PF05077.12 EMD65174.1 - 0.19 11.8 1.4 0.17 12.0 0.2 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF678) zf-C2HC5 PF06221.13 EMD65174.1 - 3.6 7.7 8.9 17 5.5 5.7 2.3 1 1 1 2 2 2 0 Putative zinc finger motif, C2HC5-type CPSF100_C PF13299.6 EMD65175.1 - 0.029 14.6 0.2 0.029 14.6 0.2 3.7 4 0 0 4 4 4 0 Cleavage and polyadenylation factor 2 C-terminal polyprenyl_synt PF00348.17 EMD65176.1 - 3.4e-64 216.4 0.0 4.2e-64 216.1 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase ThiP_synth PF10120.9 EMD65176.1 - 0.049 13.2 0.1 0.081 12.5 0.1 1.2 1 0 0 1 1 1 0 Thiamine-phosphate synthase DUF3275 PF11679.8 EMD65176.1 - 0.16 12.0 0.1 0.52 10.3 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3275) F-box-like_2 PF13013.6 EMD65177.1 - 0.00016 21.6 0.0 0.00064 19.7 0.0 2.0 2 0 0 2 2 2 1 F-box-like domain WD40 PF00400.32 EMD65178.1 - 5.3e-05 23.9 0.9 0.32 11.9 0.0 4.4 4 0 0 4 4 4 2 WD domain, G-beta repeat Sec2p PF06428.11 EMD65180.1 - 1.1e-12 47.7 13.1 3.8e-11 42.8 9.0 2.3 2 0 0 2 2 2 1 GDP/GTP exchange factor Sec2p Jnk-SapK_ap_N PF09744.9 EMD65180.1 - 3.6e-05 24.0 17.8 0.02 15.1 1.3 2.1 2 0 0 2 2 2 2 JNK_SAPK-associated protein-1 DUF4795 PF16043.5 EMD65180.1 - 0.0027 17.4 5.0 0.077 12.6 0.2 2.3 2 1 0 2 2 2 1 Domain of unknown function (DUF4795) HR1 PF02185.16 EMD65180.1 - 0.0046 17.0 17.1 0.037 14.1 0.9 2.5 2 0 0 2 2 2 1 Hr1 repeat Tropomyosin PF00261.20 EMD65180.1 - 0.007 15.8 1.9 0.007 15.8 1.9 2.1 2 0 0 2 2 2 1 Tropomyosin CENP-Q PF13094.6 EMD65180.1 - 0.0086 16.3 11.4 0.085 13.1 4.8 2.2 2 0 0 2 2 2 1 CENP-Q, a CENPA-CAD centromere complex subunit HDV_ag PF01517.18 EMD65180.1 - 0.009 15.8 1.6 0.69 9.7 0.4 2.3 2 0 0 2 2 2 1 Hepatitis delta virus delta antigen zf-ACC PF17848.1 EMD65180.1 - 0.016 15.2 0.2 0.035 14.2 0.2 1.6 1 0 0 1 1 1 0 Acetyl-coA carboxylase zinc finger domain Spc7 PF08317.11 EMD65180.1 - 0.023 13.6 1.3 0.023 13.6 1.3 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein TFIID-18kDa PF02269.16 EMD65180.1 - 0.029 14.4 2.5 0.079 13.0 2.5 1.8 1 1 0 1 1 1 0 Transcription initiation factor IID, 18kD subunit MAD PF05557.13 EMD65180.1 - 0.035 12.5 10.2 0.096 11.0 0.2 2.2 2 0 0 2 2 2 0 Mitotic checkpoint protein HAUS-augmin3 PF14932.6 EMD65180.1 - 0.039 13.5 8.8 0.19 11.3 3.0 2.1 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 3 DUF4140 PF13600.6 EMD65180.1 - 0.084 13.3 0.2 0.084 13.3 0.2 3.2 2 1 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) DHR10 PF18595.1 EMD65180.1 - 0.11 12.6 21.8 0.053 13.6 2.0 2.5 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain LXG PF04740.12 EMD65180.1 - 0.15 11.7 2.1 7.1 6.3 0.2 2.3 2 0 0 2 2 2 0 LXG domain of WXG superfamily PDCD7 PF16021.5 EMD65180.1 - 0.19 10.8 12.0 0.61 9.2 6.7 2.2 2 0 0 2 2 2 0 Programmed cell death protein 7 DUF5082 PF16888.5 EMD65180.1 - 0.24 11.7 11.6 2.4 8.4 3.3 3.3 2 2 1 3 3 3 0 Domain of unknown function (DUF5082) Phage_Mu_Gam PF07352.12 EMD65180.1 - 0.41 10.6 9.7 0.13 12.2 1.2 2.4 2 1 0 2 2 2 0 Bacteriophage Mu Gam like protein ADIP PF11559.8 EMD65180.1 - 0.44 10.6 19.8 3.7 7.6 9.4 2.8 2 1 0 2 2 2 0 Afadin- and alpha -actinin-Binding Acyl-CoA_ox_N PF14749.6 EMD65180.1 - 0.44 11.1 3.9 0.3 11.6 0.4 2.0 2 0 0 2 2 2 0 Acyl-coenzyme A oxidase N-terminal Fmp27_WPPW PF10359.9 EMD65180.1 - 0.45 9.3 7.3 2.4 6.9 0.1 2.0 2 0 0 2 2 2 0 RNA pol II promoter Fmp27 protein domain Rho_Binding PF08912.11 EMD65180.1 - 0.46 11.3 10.5 2.8 8.8 1.5 2.7 2 1 0 2 2 2 0 Rho Binding Phage_GP20 PF06810.11 EMD65180.1 - 0.46 10.3 6.9 0.77 9.6 0.2 2.8 2 1 0 2 2 2 0 Phage minor structural protein GP20 Prefoldin PF02996.17 EMD65180.1 - 0.53 10.2 6.4 3.1 7.7 1.1 3.0 2 1 0 2 2 2 0 Prefoldin subunit DELLA PF12041.8 EMD65180.1 - 0.54 10.2 1.7 1.1 9.2 0.0 2.3 3 0 0 3 3 2 0 Transcriptional regulator DELLA protein N terminal SlyX PF04102.12 EMD65180.1 - 0.55 10.9 14.3 5.2 7.8 1.1 3.7 2 2 1 3 3 3 0 SlyX LMBR1 PF04791.16 EMD65180.1 - 0.58 9.0 1.0 0.76 8.6 1.0 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein PHM7_cyt PF14703.6 EMD65180.1 - 0.6 10.3 4.8 5.5 7.2 0.1 2.2 2 0 0 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter PI3K_P85_iSH2 PF16454.5 EMD65180.1 - 0.68 9.5 9.5 0.29 10.7 0.4 2.1 2 0 0 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain DUF948 PF06103.11 EMD65180.1 - 0.7 10.2 2.9 3.4 8.0 0.1 2.4 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) HSBP1 PF06825.12 EMD65180.1 - 0.71 9.8 6.8 2.6 7.9 0.3 3.6 4 0 0 4 4 4 0 Heat shock factor binding protein 1 COG7 PF10191.9 EMD65180.1 - 0.75 7.9 3.2 2.8 6.1 0.1 2.1 2 0 0 2 2 2 0 Golgi complex component 7 (COG7) V_ATPase_I PF01496.19 EMD65180.1 - 0.77 7.6 5.3 1.5 6.7 0.0 2.0 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Occludin_ELL PF07303.13 EMD65180.1 - 0.77 10.5 6.6 1.5 9.5 0.3 2.3 2 0 0 2 2 2 0 Occludin homology domain BST2 PF16716.5 EMD65180.1 - 0.86 10.2 8.6 4 8.1 0.7 3.0 2 1 1 3 3 3 0 Bone marrow stromal antigen 2 CLZ PF16526.5 EMD65180.1 - 0.92 9.9 17.5 0.94 9.9 5.8 3.0 3 0 0 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels ABC_tran_CTD PF16326.5 EMD65180.1 - 1.1 9.6 21.4 0.19 12.0 2.7 3.4 2 1 1 3 3 3 0 ABC transporter C-terminal domain Syntaphilin PF15290.6 EMD65180.1 - 1.5 8.4 7.6 0.55 9.8 1.0 2.4 2 1 0 2 2 2 0 Golgi-localised syntaxin-1-binding clamp DUF3450 PF11932.8 EMD65180.1 - 1.8 7.8 12.3 1.7 7.9 4.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) YlqD PF11068.8 EMD65180.1 - 2.2 8.7 11.6 2.1 8.7 4.2 2.1 2 0 0 2 2 2 0 YlqD protein HrpE PF06188.12 EMD65180.1 - 2.7 7.8 9.0 0.45 10.4 4.4 1.8 2 0 0 2 2 2 0 HrpE/YscL/FliH and V-type ATPase subunit E MutS_IV PF05190.18 EMD65180.1 - 3.2 8.2 7.9 2.1 8.7 1.0 2.6 2 0 0 2 2 2 0 MutS family domain IV FlaC_arch PF05377.11 EMD65180.1 - 3.4 8.1 9.0 6.8 7.2 0.3 3.4 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) Prefoldin_2 PF01920.20 EMD65180.1 - 3.8 7.5 12.7 3.8 7.5 1.0 3.2 2 1 0 2 2 2 0 Prefoldin subunit APG6_N PF17675.1 EMD65180.1 - 4.4 7.8 20.2 0.9 10.1 0.9 2.8 2 1 0 2 2 2 0 Apg6 coiled-coil region HemX PF04375.14 EMD65180.1 - 4.5 6.5 10.3 6 6.1 3.6 2.1 2 0 0 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase Swi5 PF07061.11 EMD65180.1 - 4.8 7.3 9.3 3.5 7.8 1.4 2.8 2 1 0 2 2 2 0 Swi5 Csm1_N PF18504.1 EMD65180.1 - 5.2 7.5 13.1 1 9.8 1.1 3.0 2 1 1 3 3 3 0 Csm1 N-terminal domain Fez1 PF06818.15 EMD65180.1 - 5.5 7.4 15.8 12 6.3 5.5 2.5 1 1 1 2 2 2 0 Fez1 XhlA PF10779.9 EMD65180.1 - 6.2 7.1 14.7 1.4 9.1 2.4 3.3 2 1 1 3 3 3 0 Haemolysin XhlA Fib_alpha PF08702.10 EMD65180.1 - 6.9 6.9 7.7 7.2 6.8 0.8 2.3 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Exonuc_VII_L PF02601.15 EMD65180.1 - 8 5.9 12.3 1.4e+02 1.8 12.3 2.0 1 1 0 1 1 1 0 Exonuclease VII, large subunit UPF0242 PF06785.11 EMD65180.1 - 8.4 6.4 9.5 6.3 6.9 0.3 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus TPR_MLP1_2 PF07926.12 EMD65180.1 - 8.8 6.4 19.7 1.3 9.1 2.9 2.5 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein DUF1664 PF07889.12 EMD65180.1 - 8.8 6.4 6.7 23 5.1 1.7 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) Osmo_CC PF08946.10 EMD65180.1 - 8.9 6.7 9.5 9.7 6.5 0.7 3.1 2 1 0 2 2 2 0 Osmosensory transporter coiled coil AAA_13 PF13166.6 EMD65180.1 - 10 4.7 9.6 5.2 5.6 0.4 2.0 2 0 0 2 2 2 0 AAA domain SpaA PF17802.1 EMD65181.1 - 0.062 13.6 0.0 0.098 13.0 0.0 1.3 1 0 0 1 1 1 0 Prealbumin-like fold domain GMC_oxred_N PF00732.19 EMD65182.1 - 2.8e-57 194.4 0.0 9.8e-57 192.6 0.0 1.8 2 0 0 2 2 2 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EMD65182.1 - 1.5e-25 90.4 0.0 2.5e-25 89.7 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase DAO PF01266.24 EMD65182.1 - 1.5e-06 28.0 1.2 1.2e-05 25.1 1.2 2.1 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EMD65182.1 - 1.8e-05 24.8 0.3 4.6e-05 23.6 0.3 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EMD65182.1 - 4.9e-05 22.6 0.2 0.019 14.1 0.1 2.3 2 0 0 2 2 2 2 FAD binding domain Pyr_redox_2 PF07992.14 EMD65182.1 - 8.9e-05 21.9 0.1 0.01 15.1 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EMD65182.1 - 0.0053 16.1 0.8 2.4 7.3 0.1 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EMD65182.1 - 0.0097 15.0 0.0 0.014 14.5 0.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein DUF5510 PF17629.2 EMD65182.1 - 0.0099 15.8 0.8 0.092 12.7 0.1 2.3 2 0 0 2 2 2 1 Family of unknown function (DUF5510) HI0933_like PF03486.14 EMD65182.1 - 0.039 12.6 0.4 0.11 11.2 0.1 1.7 2 0 0 2 2 2 0 HI0933-like protein NAD_binding_9 PF13454.6 EMD65182.1 - 0.04 13.9 0.2 0.082 12.9 0.2 1.5 1 0 0 1 1 1 0 FAD-NAD(P)-binding Thi4 PF01946.17 EMD65182.1 - 0.13 11.4 0.3 0.27 10.4 0.3 1.4 1 0 0 1 1 1 0 Thi4 family Pyr_redox PF00070.27 EMD65182.1 - 0.44 11.1 2.5 0.56 10.8 0.4 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Sugar_tr PF00083.24 EMD65183.1 - 8.2e-81 272.2 15.4 9.5e-81 271.9 15.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD65183.1 - 2.4e-31 109.0 33.7 6.9e-30 104.2 14.5 1.6 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EMD65183.1 - 5.3e-09 35.1 10.5 0.00014 20.6 0.8 2.5 2 0 0 2 2 2 2 MFS/sugar transport protein TRI12 PF06609.13 EMD65183.1 - 7.6e-07 27.9 5.8 5.3e-05 21.8 0.1 2.0 2 0 0 2 2 2 2 Fungal trichothecene efflux pump (TRI12) MFS_1_like PF12832.7 EMD65183.1 - 0.00089 18.2 7.0 0.009 14.9 0.1 2.6 2 1 0 2 2 2 2 MFS_1 like family OATP PF03137.20 EMD65183.1 - 3.4 5.8 14.0 1 7.5 0.8 3.4 2 2 2 4 4 4 0 Organic Anion Transporter Polypeptide (OATP) family DUF3328 PF11807.8 EMD65186.1 - 7.1e-31 107.7 0.6 8.7e-31 107.4 0.6 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) NETI PF14044.6 EMD65186.1 - 0.18 11.6 0.0 0.28 10.9 0.0 1.3 1 0 0 1 1 1 0 NETI protein B277 PF17623.2 EMD65187.1 - 0.096 11.8 4.0 0.16 11.1 4.0 1.3 1 0 0 1 1 1 0 Domain of unknown function DUF1749 PF08538.10 EMD65189.1 - 4.8e-77 259.0 0.0 5.9e-77 258.7 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1749) Hydrolase_4 PF12146.8 EMD65189.1 - 3.7e-07 29.6 0.0 3.8e-06 26.4 0.0 2.0 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EMD65189.1 - 1.2e-05 26.1 0.0 1.8e-05 25.5 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EMD65189.1 - 2.9e-05 23.9 0.0 0.059 13.0 0.0 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EMD65189.1 - 0.0027 17.2 0.0 0.12 11.8 0.0 2.2 2 0 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_3 PF07859.13 EMD65189.1 - 0.12 12.2 0.0 0.3 10.9 0.0 1.7 1 1 0 1 1 1 0 alpha/beta hydrolase fold Ser_hydrolase PF06821.13 EMD65189.1 - 0.18 11.6 0.0 0.63 9.9 0.0 1.8 2 0 0 2 2 2 0 Serine hydrolase Meckelin PF09773.9 EMD65190.1 - 0.25 9.4 1.1 0.3 9.1 1.1 1.0 1 0 0 1 1 1 0 Meckelin (Transmembrane protein 67) DUF2207 PF09972.9 EMD65190.1 - 0.31 9.8 1.7 0.37 9.5 1.7 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF5127 PF17168.4 EMD65191.1 - 7.9e-85 284.2 5.7 1.1e-84 283.7 5.7 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF5127) DUF4965 PF16335.5 EMD65191.1 - 1.5e-79 265.7 0.6 3.5e-79 264.5 0.6 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4965) DUF1793 PF08760.11 EMD65191.1 - 1e-68 231.0 1.6 2.5e-68 229.8 0.1 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF1793) DUF4964 PF16334.5 EMD65191.1 - 4e-06 26.3 0.8 1.2e-05 24.7 0.8 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF4964) Pkinase PF00069.25 EMD65193.1 - 2.2e-46 158.4 0.0 2.7e-46 158.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD65193.1 - 3e-28 98.8 0.0 4e-28 98.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase CLN3 PF02487.17 EMD65193.1 - 0.0032 16.6 0.0 0.0048 16.0 0.0 1.1 1 0 0 1 1 1 1 CLN3 protein Kinase-like PF14531.6 EMD65193.1 - 0.024 13.9 0.4 0.24 10.7 0.0 2.4 3 0 0 3 3 3 0 Kinase-like S_layer_C PF05124.12 EMD65193.1 - 0.1 12.6 0.0 0.15 12.1 0.0 1.2 1 0 0 1 1 1 0 S-layer like family, C-terminal region Herpes_LMP1 PF05297.11 EMD65193.1 - 0.13 11.4 1.1 0.21 10.8 1.1 1.2 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) Arm PF00514.23 EMD65194.1 - 1.2e-74 244.3 31.5 6.5e-13 48.2 0.2 11.3 11 1 0 11 11 11 9 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 EMD65194.1 - 7.9e-20 71.1 8.8 3.8e-05 24.0 0.0 7.3 4 2 2 7 7 7 5 HEAT repeats HEAT_EZ PF13513.6 EMD65194.1 - 1.9e-19 69.8 14.9 5.6e-06 26.7 0.3 8.1 6 2 3 9 9 9 6 HEAT-like repeat HEAT PF02985.22 EMD65194.1 - 6.8e-17 60.1 14.3 0.083 13.2 0.0 9.3 10 0 0 10 10 9 5 HEAT repeat Adaptin_N PF01602.20 EMD65194.1 - 4.3e-13 48.7 8.1 1.7e-08 33.5 1.2 2.7 1 1 1 2 2 2 2 Adaptin N terminal region KAP PF05804.12 EMD65194.1 - 4.1e-12 45.1 0.3 8.3e-12 44.1 0.3 1.5 1 0 0 1 1 1 1 Kinesin-associated protein (KAP) Arm_2 PF04826.13 EMD65194.1 - 6.5e-11 42.2 5.5 1.3e-06 28.1 1.9 2.5 1 1 0 2 2 2 2 Armadillo-like V-ATPase_H_N PF03224.14 EMD65194.1 - 2.1e-08 33.8 2.5 2.8e-05 23.6 0.5 3.4 2 1 1 3 3 3 2 V-ATPase subunit H Cnd1 PF12717.7 EMD65194.1 - 9.1e-07 29.0 7.7 0.0067 16.5 0.3 5.4 2 2 1 5 5 5 1 non-SMC mitotic condensation complex subunit 1 DUF3361 PF11841.8 EMD65194.1 - 2.3e-05 24.4 9.4 0.24 11.3 0.1 4.4 2 1 2 5 5 5 2 Domain of unknown function (DUF3361) RTP1_C1 PF10363.9 EMD65194.1 - 0.0029 17.8 3.5 9.2 6.5 0.0 5.0 3 1 0 4 4 4 1 Required for nuclear transport of RNA pol II C-terminus 1 Proteasom_PSMB PF10508.9 EMD65194.1 - 0.007 14.9 2.2 0.56 8.6 0.3 3.4 3 1 1 4 4 4 2 Proteasome non-ATPase 26S subunit DAP_B PF07930.12 EMD65194.1 - 0.0084 16.1 0.0 0.015 15.3 0.0 1.3 1 0 0 1 1 1 1 D-aminopeptidase, domain B Atx10homo_assoc PF09759.9 EMD65194.1 - 0.0088 16.0 7.2 1 9.4 0.1 4.9 3 2 2 5 5 5 1 Spinocerebellar ataxia type 10 protein domain HEAT_PBS PF03130.16 EMD65194.1 - 0.036 14.7 10.2 10 7.1 0.8 6.5 7 0 0 7 7 5 0 PBS lyase HEAT-like repeat UNC45-central PF11701.8 EMD65194.1 - 0.038 14.0 2.5 11 6.0 0.1 3.6 2 2 1 3 3 3 0 Myosin-binding striated muscle assembly central Vac14_Fab1_bd PF12755.7 EMD65194.1 - 0.12 13.0 0.0 7.4 7.2 0.0 3.3 1 1 3 4 4 4 0 Vacuolar 14 Fab1-binding region YqfD PF06898.11 EMD65194.1 - 0.14 10.9 0.0 0.28 10.0 0.0 1.4 1 0 0 1 1 1 0 Putative stage IV sporulation protein YqfD Vpu PF00558.19 EMD65194.1 - 0.15 11.9 3.0 0.12 12.1 0.9 2.0 2 0 0 2 2 2 0 Vpu protein RNA_pol_Rpc4 PF05132.14 EMD65195.1 - 1.8e-30 106.3 0.2 1.8e-30 106.3 0.2 5.0 3 2 0 3 3 3 1 RNA polymerase III RPC4 HATPase_c PF02518.26 EMD65196.1 - 2.2e-22 79.7 0.0 4.3e-22 78.7 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EMD65196.1 - 1.3e-18 67.2 0.0 3.2e-18 65.9 0.0 1.8 1 0 0 1 1 1 1 Response regulator receiver domain PAS_4 PF08448.10 EMD65196.1 - 3.5e-10 40.1 0.1 0.00064 20.0 0.0 4.0 3 0 0 3 3 3 2 PAS fold HisKA PF00512.25 EMD65196.1 - 1.9e-08 34.2 0.1 7.5e-08 32.3 0.1 2.2 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain PAS_9 PF13426.7 EMD65196.1 - 2.2e-08 34.3 0.0 0.044 14.0 0.0 3.6 3 0 0 3 3 3 2 PAS domain PAS_3 PF08447.12 EMD65196.1 - 2.3e-07 31.0 0.3 0.0029 17.9 0.0 3.4 2 1 0 2 2 2 2 PAS fold PAS PF00989.25 EMD65196.1 - 3.9e-06 26.8 0.0 0.064 13.3 0.0 4.3 3 1 0 3 3 3 2 PAS fold GAF_2 PF13185.6 EMD65196.1 - 0.0048 17.2 0.0 0.12 12.6 0.0 2.6 2 0 0 2 2 2 1 GAF domain PAS_8 PF13188.7 EMD65196.1 - 0.02 14.9 0.0 0.23 11.5 0.0 2.7 3 0 0 3 3 3 0 PAS domain Ribonuc_red_sm PF00268.21 EMD65197.1 - 1.3e-121 405.4 0.7 1.5e-121 405.1 0.7 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain WD40 PF00400.32 EMD65198.1 - 1.2e-25 89.2 6.6 1.6e-06 28.7 0.1 7.7 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD65198.1 - 8.8e-05 22.7 0.0 13 6.2 0.0 4.5 2 1 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 EMD65198.1 - 0.014 15.4 0.1 2.6 8.1 0.0 3.9 3 2 1 4 4 4 0 Ciliary BBSome complex subunit 2, middle region WD40_like PF17005.5 EMD65198.1 - 0.067 12.5 0.0 5.9 6.1 0.0 2.5 3 0 0 3 3 3 0 WD40-like domain AAA_lid_2 PF17863.1 EMD65199.1 - 7.2e-06 25.7 3.4 1.1e-05 25.2 0.4 2.6 3 0 0 3 3 3 1 AAA lid domain AAA_3 PF07726.11 EMD65199.1 - 0.00089 19.1 0.0 0.0018 18.2 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ORC4_C PF14629.6 EMD65199.1 - 0.037 13.4 0.1 0.06 12.7 0.1 1.3 1 0 0 1 1 1 0 Origin recognition complex (ORC) subunit 4 C-terminus NAD_kinase PF01513.21 EMD65200.1 - 6.2e-76 255.4 0.0 9.7e-76 254.7 0.0 1.2 1 0 0 1 1 1 1 ATP-NAD kinase DAGK_cat PF00781.24 EMD65200.1 - 0.01 15.5 0.0 0.021 14.4 0.0 1.5 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain Amidohydro_1 PF01979.20 EMD65201.1 - 5.5e-20 72.0 0.0 2.1e-19 70.0 0.0 1.8 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EMD65201.1 - 5.4e-06 26.1 0.0 0.0025 17.4 0.0 2.2 2 0 0 2 2 2 2 Amidohydrolase family Porphobil_deam PF01379.20 EMD65203.1 - 1.6e-71 240.1 0.0 2.2e-71 239.6 0.0 1.2 1 0 0 1 1 1 1 Porphobilinogen deaminase, dipyromethane cofactor binding domain Porphobil_deamC PF03900.15 EMD65203.1 - 7e-17 61.6 4.5 1.7e-15 57.2 4.5 2.4 1 1 0 1 1 1 1 Porphobilinogen deaminase, C-terminal domain Ribosomal_L12 PF00542.19 EMD65203.1 - 1.2 9.5 7.2 2.9 8.3 7.2 1.6 1 0 0 1 1 1 0 Ribosomal protein L7/L12 C-terminal domain MFS_1 PF07690.16 EMD65204.1 - 1.7e-29 102.8 26.2 1.7e-29 102.8 26.2 1.6 1 1 1 2 2 2 1 Major Facilitator Superfamily PLAC8 PF04749.17 EMD65205.1 - 7.9e-23 81.3 10.5 1.3e-22 80.7 10.5 1.3 1 0 0 1 1 1 1 PLAC8 family Neur_chan_memb PF02932.16 EMD65206.1 - 0.16 12.0 8.8 0.18 11.8 8.8 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CDC45 PF02724.14 EMD65206.1 - 1.8 6.8 17.5 2.1 6.6 17.5 1.2 1 0 0 1 1 1 0 CDC45-like protein DUF908 PF06012.12 EMD65206.1 - 2 7.8 10.2 2.1 7.7 10.2 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) SLC12 PF03522.15 EMD65206.1 - 6.3 5.7 14.6 7.8 5.4 14.6 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Macoilin PF09726.9 EMD65206.1 - 9.9 4.6 18.5 12 4.3 18.5 1.0 1 0 0 1 1 1 0 Macoilin family TIP120 PF08623.10 EMD65207.1 - 6.7e-66 221.2 0.7 9.4e-65 217.5 0.1 3.2 3 0 0 3 3 2 1 TATA-binding protein interacting (TIP20) HEAT_2 PF13646.6 EMD65207.1 - 2.8e-13 50.1 15.8 0.03 14.7 1.5 8.4 7 2 2 9 9 9 6 HEAT repeats DUF3385 PF11865.8 EMD65207.1 - 6.3e-07 29.4 1.2 1.2 9.1 0.0 6.0 5 1 1 6 6 6 1 Domain of unknown function (DUF3385) HEAT PF02985.22 EMD65207.1 - 3.3e-06 26.9 17.9 1.2 9.6 0.1 10.5 12 0 0 12 12 10 1 HEAT repeat Adaptin_N PF01602.20 EMD65207.1 - 3.6e-06 25.8 4.0 1.6 7.2 0.4 6.2 4 3 1 5 5 5 2 Adaptin N terminal region MMS19_C PF12460.8 EMD65207.1 - 2.5e-05 23.6 8.5 0.38 9.8 0.3 5.3 4 1 0 4 4 4 2 RNAPII transcription regulator C-terminal MMS19_N PF14500.6 EMD65207.1 - 4.8e-05 23.1 8.2 0.93 9.0 0.2 6.2 6 0 0 6 6 6 1 Dos2-interacting transcription regulator of RNA-Pol-II DUF3361 PF11841.8 EMD65207.1 - 0.00024 21.1 0.1 3.2 7.7 0.0 4.6 4 1 0 4 4 4 1 Domain of unknown function (DUF3361) IFRD PF05004.13 EMD65207.1 - 0.0014 17.8 2.1 0.0041 16.3 0.2 2.8 3 0 0 3 3 3 1 Interferon-related developmental regulator (IFRD) Cnd1 PF12717.7 EMD65207.1 - 0.0019 18.2 3.7 0.77 9.8 0.0 5.5 6 0 0 6 6 6 1 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 EMD65207.1 - 0.0051 17.3 29.2 13 6.4 0.1 12.2 14 1 1 15 15 15 0 HEAT-like repeat Cnd3 PF12719.7 EMD65207.1 - 0.024 13.9 1.0 17 4.5 0.0 4.5 5 0 0 5 5 5 0 Nuclear condensing complex subunits, C-term domain TAF6_C PF07571.13 EMD65207.1 - 0.03 14.6 0.0 9.5 6.6 0.0 3.9 4 0 0 4 4 3 0 TAF6 C-terminal HEAT repeat domain RTP1_C1 PF10363.9 EMD65207.1 - 0.065 13.4 5.5 13 6.0 0.0 5.4 7 0 0 7 7 7 0 Required for nuclear transport of RNA pol II C-terminus 1 Importin_rep_4 PF18808.1 EMD65207.1 - 0.13 12.6 2.2 2.8 8.3 0.0 4.0 3 0 0 3 3 2 0 Importin repeat Arm PF00514.23 EMD65207.1 - 0.22 11.6 7.5 16 5.7 0.0 5.1 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat PAN_4 PF14295.6 EMD65208.1 - 0.11 12.4 1.2 0.49 10.3 0.2 2.5 2 0 0 2 2 2 0 PAN domain DUF2263 PF10021.9 EMD65209.1 - 3.2e-16 60.0 0.0 7.1e-16 58.9 0.0 1.6 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2263) PseudoU_synth_2 PF00849.22 EMD65210.1 - 1.6e-27 96.6 0.0 2.6e-27 95.9 0.0 1.4 1 0 0 1 1 1 1 RNA pseudouridylate synthase S4 PF01479.25 EMD65210.1 - 0.0057 16.3 0.5 0.011 15.4 0.1 1.7 2 0 0 2 2 2 1 S4 domain 4HBT PF03061.22 EMD65211.1 - 1.8e-10 41.0 0.0 2.4e-10 40.6 0.0 1.2 1 0 0 1 1 1 1 Thioesterase superfamily 4HBT_2 PF13279.6 EMD65211.1 - 7e-06 26.5 0.0 9.9e-06 26.1 0.0 1.2 1 0 0 1 1 1 1 Thioesterase-like superfamily Acyl-ACP_TE PF01643.17 EMD65211.1 - 1.9e-05 24.1 3.6 0.00014 21.3 2.4 2.0 1 1 1 2 2 2 1 Acyl-ACP thioesterase TPR_12 PF13424.6 EMD65213.1 - 1e-05 25.7 4.0 0.016 15.5 0.1 4.3 3 1 1 4 4 4 3 Tetratricopeptide repeat YfdX PF10938.8 EMD65213.1 - 0.14 12.1 0.2 64 3.4 0.0 3.2 2 1 0 3 3 3 0 YfdX protein TonB_N PF16031.5 EMD65213.1 - 5.2 7.6 8.5 3 8.4 0.2 2.2 2 0 0 2 2 2 0 TonB polyproline region FOXP-CC PF16159.5 EMD65214.1 - 0.00013 22.6 0.4 0.00013 22.6 0.4 1.8 2 0 0 2 2 2 1 FOXP coiled-coil domain zf-C2H2 PF00096.26 EMD65214.1 - 0.0043 17.4 9.0 0.19 12.3 1.3 2.8 2 1 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_8 PF15909.5 EMD65214.1 - 0.025 14.9 0.0 0.057 13.7 0.0 1.6 1 0 0 1 1 1 0 C2H2-type zinc ribbon zf-C2H2_4 PF13894.6 EMD65214.1 - 0.36 11.8 10.4 1.4 9.9 1.2 3.0 3 0 0 3 3 3 0 C2H2-type zinc finger SET PF00856.28 EMD65215.1 - 5.8e-10 39.8 0.0 2.3e-09 37.9 0.0 1.9 1 1 0 1 1 1 1 SET domain GFA PF04828.14 EMD65216.1 - 5.6e-13 49.0 0.1 7.2e-13 48.7 0.1 1.2 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme Tn916-Xis PF09035.10 EMD65216.1 - 0.13 12.5 0.0 0.2 11.9 0.0 1.2 1 0 0 1 1 1 0 Excisionase from transposon Tn916 Auto_anti-p27 PF06677.12 EMD65216.1 - 0.6 10.3 6.6 0.82 9.9 0.1 2.5 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) Apc13p PF05839.11 EMD65217.1 - 4.5e-32 110.1 0.3 5.6e-32 109.8 0.3 1.1 1 0 0 1 1 1 1 Apc13p protein zf-RING_2 PF13639.6 EMD65218.1 - 4.3e-05 23.7 11.7 0.0002 21.6 9.5 2.4 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.25 EMD65218.1 - 9.5e-05 22.2 11.1 0.00027 20.7 11.1 1.9 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EMD65218.1 - 0.00058 20.0 8.5 0.00058 20.0 8.5 2.0 3 0 0 3 3 3 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.6 EMD65218.1 - 0.00063 19.6 12.5 0.0027 17.5 8.9 2.8 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EMD65218.1 - 0.0012 19.0 11.3 0.004 17.4 11.3 1.9 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 EMD65218.1 - 0.0023 17.8 8.9 0.0023 17.8 8.9 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EMD65218.1 - 0.012 15.5 13.6 0.063 13.1 13.4 2.1 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 EMD65218.1 - 0.021 14.9 4.7 0.047 13.7 2.9 2.3 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 EMD65218.1 - 0.042 13.9 11.4 0.04 14.0 9.8 2.0 1 1 0 1 1 1 0 RING-type zinc-finger zf-RING_5 PF14634.6 EMD65218.1 - 0.078 13.0 13.0 0.36 10.8 13.0 2.1 1 1 0 1 1 1 0 zinc-RING finger domain XPG_I PF00867.18 EMD65219.1 - 7.2e-25 87.2 0.0 1.7e-24 86.0 0.0 1.7 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.17 EMD65219.1 - 8.6e-07 29.4 0.0 4.9e-05 23.7 0.0 2.7 2 0 0 2 2 2 1 XPG N-terminal domain UIM PF02809.20 EMD65219.1 - 0.001 18.8 6.1 0.001 18.8 6.1 2.0 2 0 0 2 2 2 1 Ubiquitin interaction motif Zn_clus PF00172.18 EMD65220.1 - 2.2e-05 24.5 8.0 8.3e-05 22.6 8.0 2.0 1 1 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Say1_Mug180 PF10340.9 EMD65222.1 - 2.4e-25 89.2 0.0 2.9e-25 88.9 0.0 1.1 1 0 0 1 1 1 1 Steryl acetyl hydrolase Abhydrolase_3 PF07859.13 EMD65222.1 - 1.4e-23 83.9 0.0 1.8e-23 83.5 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF3425 PF11905.8 EMD65223.1 - 8.9e-20 70.9 1.0 3.2e-19 69.1 1.0 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF3425) DUF4349 PF14257.6 EMD65223.1 - 0.004 16.6 0.8 0.0064 16.0 0.8 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4349) bZIP_1 PF00170.21 EMD65223.1 - 0.0093 16.1 6.5 0.03 14.4 3.5 2.2 2 0 0 2 2 2 1 bZIP transcription factor Pox_polyA_pol PF03296.13 EMD65224.1 - 0.15 11.9 0.1 0.73 9.7 0.0 1.8 2 0 0 2 2 2 0 Poxvirus poly(A) polymerase nucleotidyltransferase domain AMP-binding PF00501.28 EMD65225.1 - 4.9e-39 134.1 0.0 8.4e-39 133.4 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme ACAS_N PF16177.5 EMD65225.1 - 1.2e-05 25.1 0.1 1.2e-05 25.1 0.1 2.9 3 0 0 3 3 3 1 Acetyl-coenzyme A synthetase N-terminus AMP-binding_C PF13193.6 EMD65225.1 - 0.00066 20.6 0.1 0.0026 18.7 0.0 2.1 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain PI-PLC-X PF00388.19 EMD65228.1 - 1.8e-46 157.4 0.0 3e-46 156.6 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 EMD65228.1 - 5e-38 130.0 0.0 9.5e-38 129.1 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain C2 PF00168.30 EMD65228.1 - 0.0089 16.3 0.0 0.024 14.9 0.0 1.7 1 0 0 1 1 1 1 C2 domain IMUP PF15761.5 EMD65228.1 - 0.033 14.9 0.5 0.079 13.6 0.5 1.6 1 0 0 1 1 1 0 Immortalisation up-regulated protein MFS_1 PF07690.16 EMD65229.1 - 3.1e-09 36.2 31.1 5.6e-09 35.4 22.2 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily UNC-93 PF05978.16 EMD65229.1 - 0.00011 21.9 3.9 0.00026 20.8 3.9 1.6 1 0 0 1 1 1 1 Ion channel regulatory protein UNC-93 2OG-FeII_Oxy_2 PF13532.6 EMD65230.1 - 1.2e-22 81.1 0.0 2e-22 80.4 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Glyco_hydro_18 PF00704.28 EMD65232.1 - 3.8e-50 171.4 0.1 4.3e-50 171.2 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 LysM PF01476.20 EMD65233.1 - 0.00022 21.2 0.6 0.0027 17.7 0.1 2.9 3 0 0 3 3 3 1 LysM domain LysM PF01476.20 EMD65234.1 - 9.3e-05 22.4 0.1 0.00014 21.9 0.1 1.3 1 0 0 1 1 1 1 LysM domain Cyclase PF04199.13 EMD65236.1 - 6e-15 55.7 0.5 1.6e-14 54.3 0.4 1.7 1 1 0 1 1 1 1 Putative cyclase LPD22 PF18834.1 EMD65236.1 - 0.037 14.2 0.0 0.092 13.0 0.0 1.7 1 0 0 1 1 1 0 Large polyvalent protein associated domain 22 DUF4449 PF14613.6 EMD65237.1 - 1.2e-67 227.1 6.5 1.2e-67 227.1 6.5 2.6 4 0 0 4 4 4 1 Protein of unknown function (DUF4449) RbsD_FucU PF05025.13 EMD65237.1 - 0.0065 16.9 0.2 0.043 14.2 0.1 2.5 3 0 0 3 3 3 1 RbsD / FucU transport protein family Prp18 PF02840.15 EMD65237.1 - 0.37 10.8 0.0 0.37 10.8 0.0 3.6 2 2 2 4 4 4 0 Prp18 domain Herpes_BLRF2 PF05812.12 EMD65237.1 - 0.39 10.9 6.4 0.31 11.2 0.4 3.1 2 1 1 3 3 3 0 Herpesvirus BLRF2 protein CorA PF01544.18 EMD65238.1 - 4.7e-12 45.8 0.0 1.2e-11 44.5 0.0 1.6 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein PMP22_Claudin PF00822.20 EMD65238.1 - 0.11 12.4 0.0 0.25 11.2 0.0 1.5 1 0 0 1 1 1 0 PMP-22/EMP/MP20/Claudin family PH PF00169.29 EMD65239.1 - 2.8e-30 104.9 0.9 5.8e-15 55.7 0.1 2.3 2 0 0 2 2 2 2 PH domain PH_11 PF15413.6 EMD65239.1 - 6.8e-10 39.3 3.7 0.00055 20.3 0.2 3.7 2 2 0 2 2 2 2 Pleckstrin homology domain PH_9 PF15410.6 EMD65239.1 - 1.3e-09 38.5 0.6 2.3e-05 24.7 0.2 3.5 2 2 0 2 2 2 2 Pleckstrin homology domain PH_8 PF15409.6 EMD65239.1 - 1.3e-05 25.4 0.3 6.6e-05 23.1 0.1 2.1 2 0 0 2 2 2 1 Pleckstrin homology domain PH_3 PF14593.6 EMD65239.1 - 2.7e-05 24.2 0.7 0.00013 22.0 0.1 2.1 2 1 0 2 2 2 1 PH domain Myosin_TH1 PF06017.13 EMD65239.1 - 0.084 12.6 0.1 0.14 11.8 0.1 1.3 1 0 0 1 1 1 0 Unconventional myosin tail, actin- and lipid-binding GTP_EFTU PF00009.27 EMD65240.1 - 9.9e-58 194.9 0.0 1.7e-57 194.1 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 EMD65240.1 - 1.8e-14 53.5 0.0 4.7e-14 52.2 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 EMD65240.1 - 4e-10 39.9 0.0 1.8e-09 37.8 0.0 2.1 2 0 0 2 2 2 1 Elongation factor Tu domain 2 EFG_II PF14492.6 EMD65240.1 - 9.4e-08 32.0 0.0 2e-07 31.0 0.0 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_IV PF03764.18 EMD65240.1 - 0.032 14.0 0.0 0.11 12.2 0.0 2.0 1 0 0 1 1 1 0 Elongation factor G, domain IV MMR_HSR1 PF01926.23 EMD65240.1 - 0.073 13.2 0.0 0.2 11.7 0.0 1.8 1 1 0 1 1 1 0 50S ribosome-binding GTPase D123 PF07065.14 EMD65240.1 - 0.17 11.0 0.1 0.27 10.3 0.1 1.3 1 0 0 1 1 1 0 D123 HIP1_clath_bdg PF16515.5 EMD65240.1 - 7.3 7.3 6.2 2 9.1 0.2 2.8 3 1 1 4 4 4 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Zn_clus PF00172.18 EMD65241.1 - 2.6e-07 30.6 11.6 4.4e-07 29.9 11.6 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Dickkopf_N PF04706.12 EMD65241.1 - 9.1 6.8 6.6 17 6.0 1.1 2.4 2 0 0 2 2 2 0 Dickkopf N-terminal cysteine-rich region Ras PF00071.22 EMD65242.1 - 6.2e-57 191.7 0.1 7.8e-57 191.4 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMD65242.1 - 3e-32 111.4 0.0 4.2e-32 110.9 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMD65242.1 - 2.5e-12 46.6 0.0 3e-12 46.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EMD65242.1 - 1.1e-07 31.9 0.0 1.7e-07 31.3 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EMD65242.1 - 3.1e-06 26.7 0.0 3.8e-06 26.4 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EMD65242.1 - 1.6e-05 24.5 0.0 0.00082 19.0 0.0 2.2 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EMD65242.1 - 6.8e-05 22.8 0.1 0.0038 17.2 0.1 2.3 1 1 2 3 3 3 1 RsgA GTPase ATP_bind_1 PF03029.17 EMD65242.1 - 0.00027 20.8 0.4 0.007 16.2 0.1 2.0 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein PduV-EutP PF10662.9 EMD65242.1 - 0.0028 17.4 0.1 0.12 12.1 0.0 2.2 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation cobW PF02492.19 EMD65242.1 - 0.0059 16.2 0.0 0.034 13.7 0.0 1.9 1 1 2 3 3 3 1 CobW/HypB/UreG, nucleotide-binding domain Septin PF00735.18 EMD65242.1 - 0.006 15.9 0.1 0.062 12.6 0.0 2.1 2 0 0 2 2 2 1 Septin AAA_16 PF13191.6 EMD65242.1 - 0.0072 16.7 0.0 0.011 16.1 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain SRPRB PF09439.10 EMD65242.1 - 0.0082 15.6 0.0 0.01 15.3 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_22 PF13401.6 EMD65242.1 - 0.0088 16.3 0.0 0.016 15.5 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 EMD65242.1 - 0.011 15.8 0.0 0.015 15.3 0.0 1.5 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 EMD65242.1 - 0.022 14.5 0.0 0.038 13.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EMD65242.1 - 0.026 14.0 0.1 0.045 13.3 0.1 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region Glyco_hydro_75 PF07335.11 EMD65242.1 - 0.062 13.6 0.0 0.082 13.2 0.0 1.4 1 0 0 1 1 1 0 Fungal chitosanase of glycosyl hydrolase group 75 ATPase_2 PF01637.18 EMD65242.1 - 0.069 13.1 0.2 0.13 12.1 0.1 1.5 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea TniB PF05621.11 EMD65242.1 - 0.11 11.9 0.0 0.17 11.2 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein NACHT PF05729.12 EMD65242.1 - 0.13 12.2 0.0 0.19 11.6 0.0 1.3 1 0 0 1 1 1 0 NACHT domain FeoB_N PF02421.18 EMD65242.1 - 0.13 11.8 0.0 1.6 8.2 0.0 2.1 2 0 0 2 2 2 0 Ferrous iron transport protein B NTPase_1 PF03266.15 EMD65242.1 - 0.16 11.9 0.0 0.23 11.3 0.0 1.3 1 0 0 1 1 1 0 NTPase EamA PF00892.20 EMD65243.1 - 2.5e-09 37.4 32.5 3.6e-06 27.2 4.2 3.1 3 0 0 3 3 3 3 EamA-like transporter family PUNUT PF16913.5 EMD65243.1 - 6e-07 29.0 0.7 6e-07 29.0 0.7 2.4 3 0 0 3 3 3 1 Purine nucleobase transmembrane transport SLC35F PF06027.12 EMD65243.1 - 3.5e-06 26.7 1.7 3.5e-06 26.7 1.7 2.4 3 0 0 3 3 3 1 Solute carrier family 35 DUF3955 PF13127.6 EMD65243.1 - 1.4e-05 24.8 1.7 8.1e-05 22.4 1.7 2.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3955) CitMHS_2 PF16980.5 EMD65243.1 - 3.1e-05 22.8 1.1 0.044 12.4 0.0 2.3 2 0 0 2 2 2 2 Putative citrate transport UAA PF08449.11 EMD65243.1 - 0.029 13.6 8.8 0.058 12.6 8.8 1.5 1 0 0 1 1 1 0 UAA transporter family TruB_N PF01509.18 EMD65244.1 - 2.9e-45 154.3 0.0 7.3e-45 153.0 0.0 1.6 1 0 0 1 1 1 1 TruB family pseudouridylate synthase (N terminal domain) TruB_C_2 PF16198.5 EMD65244.1 - 3e-06 27.3 0.0 6.3e-06 26.3 0.0 1.6 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain DnaJ PF00226.31 EMD65245.1 - 3.9e-18 65.3 1.0 1.3e-17 63.7 1.0 1.9 1 0 0 1 1 1 1 DnaJ domain RRM_1 PF00076.22 EMD65245.1 - 0.12 12.3 0.0 0.33 10.8 0.0 1.8 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Rotamase PF00639.21 EMD65245.1 - 3.5 8.7 5.9 5.5 8.0 0.1 2.9 2 1 0 2 2 2 0 PPIC-type PPIASE domain OmpH PF03938.14 EMD65245.1 - 8 6.8 14.8 4.3 7.7 11.8 2.0 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) MARVEL PF01284.23 EMD65246.1 - 0.00077 19.5 3.3 0.0025 17.8 3.5 1.8 1 1 0 1 1 1 1 Membrane-associating domain DUF4231 PF14015.6 EMD65246.1 - 0.0032 17.9 0.7 0.026 15.0 0.0 2.3 1 1 1 2 2 2 1 Protein of unknown function (DUF4231) DUF588 PF04535.12 EMD65246.1 - 0.045 13.5 1.6 0.14 12.0 1.6 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF588) Gemini_mov PF01708.16 EMD65246.1 - 8.2 6.3 6.0 60 3.5 0.0 3.2 3 0 0 3 3 3 0 Geminivirus putative movement protein APH PF01636.23 EMD65247.1 - 1.1e-10 41.9 0.0 7.3e-10 39.2 0.0 2.0 1 1 0 1 1 1 1 Phosphotransferase enzyme family DUF1679 PF07914.11 EMD65247.1 - 0.0012 17.8 0.1 0.64 8.8 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF1679) EcKinase PF02958.20 EMD65247.1 - 0.042 13.2 0.0 0.074 12.3 0.0 1.3 1 0 0 1 1 1 0 Ecdysteroid kinase DUF3382 PF11862.8 EMD65249.1 - 0.074 13.3 0.0 0.14 12.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3382) PgaD PF13994.6 EMD65249.1 - 0.16 12.0 0.0 0.25 11.4 0.0 1.3 1 0 0 1 1 1 0 PgaD-like protein Glyco_hydro_127 PF07944.12 EMD65250.1 - 1.5e-136 455.9 1.0 1.8e-136 455.7 1.0 1.0 1 0 0 1 1 1 1 Beta-L-arabinofuranosidase, GH127 DUF4986 PF16375.5 EMD65250.1 - 0.017 15.8 0.0 0.041 14.6 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function Glyco_transf_28 PF03033.20 EMD65251.1 - 6e-24 84.7 0.0 1.4e-23 83.4 0.0 1.7 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain UDPGT PF00201.18 EMD65251.1 - 1.3e-06 27.6 0.0 1.9e-06 26.9 0.0 1.2 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase ATG_C PF09333.11 EMD65251.1 - 0.0017 18.7 0.0 0.0091 16.3 0.0 2.2 2 0 0 2 2 2 1 Autophagy-related protein C terminal domain Bac_rhamnosid_C PF17390.2 EMD65252.1 - 8.1e-10 38.4 0.5 2e-09 37.1 0.1 1.8 2 0 0 2 2 2 1 Bacterial alpha-L-rhamnosidase C-terminal domain Bac_rhamnosid6H PF17389.2 EMD65252.1 - 1.4e-06 27.8 0.0 5.5e-05 22.6 0.0 2.2 2 0 0 2 2 2 1 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain Laminin_G_1 PF00054.23 EMD65252.1 - 0.022 15.0 0.0 0.046 13.9 0.0 1.5 1 0 0 1 1 1 0 Laminin G domain DUF1080 PF06439.11 EMD65252.1 - 0.045 13.9 0.0 0.32 11.1 0.0 2.1 1 1 0 1 1 1 0 Domain of Unknown Function (DUF1080) DUF2939 PF11159.8 EMD65252.1 - 0.1 13.0 0.1 0.24 11.8 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2939) Fungal_trans_2 PF11951.8 EMD65253.1 - 5.3e-08 32.1 0.1 7.5e-08 31.6 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD65253.1 - 1.1e-07 31.8 9.1 2e-07 31.0 9.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Cad PF03596.13 EMD65254.1 - 1.6e-05 24.9 18.9 0.0029 17.5 2.9 2.6 1 1 2 3 3 3 2 Cadmium resistance transporter PepSY_TM PF03929.16 EMD65254.1 - 0.15 11.7 0.2 0.32 10.6 0.2 1.4 1 0 0 1 1 1 0 PepSY-associated TM region S1FA PF04689.13 EMD65254.1 - 0.18 12.0 3.4 0.24 11.6 0.2 2.5 2 0 0 2 2 2 0 DNA binding protein S1FA Insulin_TMD PF17870.1 EMD65254.1 - 0.28 11.3 0.3 0.28 11.3 0.3 3.5 4 0 0 4 4 4 0 Insulin receptor trans-membrane segment DUF2070 PF09843.9 EMD65254.1 - 0.33 9.2 8.9 0.38 9.0 8.9 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) TssN PF17555.2 EMD65254.1 - 0.48 9.8 9.8 0.63 9.4 9.8 1.2 1 0 0 1 1 1 0 Type VI secretion system, TssN SPC25 PF06703.11 EMD65254.1 - 0.69 9.7 3.1 11 5.8 1.5 2.2 2 0 0 2 2 2 0 Microsomal signal peptidase 25 kDa subunit (SPC25) Phage_holin_3_6 PF07332.11 EMD65254.1 - 1.8 8.6 13.8 3.3 7.8 0.1 2.2 1 1 1 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III RVT_1 PF00078.27 EMD65256.1 - 3.7e-09 36.4 2.2 3.9e-09 36.4 2.2 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Zn_clus PF00172.18 EMD65261.1 - 1.9e-09 37.5 5.9 3.1e-09 36.8 5.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EMD65261.1 - 7.3e-07 28.3 1.5 1.1e-06 27.8 1.5 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain RTA1 PF04479.13 EMD65262.1 - 6e-51 173.0 5.4 8.9e-51 172.4 5.4 1.2 1 0 0 1 1 1 1 RTA1 like protein DUF2165 PF09933.9 EMD65262.1 - 0.0031 17.6 0.2 0.0081 16.2 0.2 1.7 1 0 0 1 1 1 1 Predicted small integral membrane protein (DUF2165) TMEM240 PF15207.6 EMD65262.1 - 0.049 13.3 0.2 0.067 12.9 0.2 1.2 1 0 0 1 1 1 0 TMEM240 family Pkinase PF00069.25 EMD65263.1 - 2.4e-18 66.4 0.0 3.6e-18 65.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD65263.1 - 8.1e-07 28.6 0.0 1.3e-06 27.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PAN_4 PF14295.6 EMD65264.1 - 4.5e-12 45.7 6.7 1e-07 31.7 1.0 3.5 4 0 0 4 4 4 2 PAN domain PAN_1 PF00024.26 EMD65264.1 - 6e-12 45.4 5.3 3.2e-06 27.0 0.3 2.3 2 0 0 2 2 2 2 PAN domain PAN_3 PF08277.12 EMD65264.1 - 1.7e-07 30.9 4.4 0.006 16.4 0.6 2.5 2 0 0 2 2 2 2 PAN-like domain PAN_2 PF08276.11 EMD65264.1 - 0.0024 18.0 15.8 0.039 14.1 1.5 2.9 3 0 0 3 3 3 2 PAN-like domain MANEC PF07502.14 EMD65264.1 - 0.041 14.1 0.1 0.041 14.1 0.1 3.2 2 1 0 2 2 2 0 MANEC domain Peptidase_C3G PF12381.8 EMD65264.1 - 0.076 12.5 0.4 0.11 12.0 0.4 1.1 1 0 0 1 1 1 0 Tungro spherical virus-type peptidase Antifungal_prot PF11402.8 EMD65264.1 - 0.13 12.6 2.5 0.25 11.6 0.1 2.8 2 1 1 3 3 3 0 Antifungal protein Kelch_3 PF13415.6 EMD65264.1 - 0.18 12.1 4.2 32 5.0 0.0 3.5 3 1 0 3 3 3 0 Galactose oxidase, central domain FAA_hydrolase PF01557.18 EMD65266.1 - 6.2e-65 218.9 0.0 1.4e-64 217.7 0.0 1.6 2 0 0 2 2 2 1 Fumarylacetoacetate (FAA) hydrolase family Abhydrolase_6 PF12697.7 EMD65266.1 - 1.3e-18 68.4 0.1 1.9e-18 67.9 0.1 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EMD65266.1 - 1.6e-18 67.3 0.1 2.6e-14 53.5 0.1 2.2 1 1 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EMD65266.1 - 3.8e-16 59.1 0.0 7.7e-16 58.1 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Ser_hydrolase PF06821.13 EMD65266.1 - 3.1e-06 27.2 0.3 3e-05 23.9 0.1 2.1 1 1 1 2 2 2 1 Serine hydrolase Ndr PF03096.14 EMD65266.1 - 0.019 13.7 0.0 0.027 13.2 0.0 1.2 1 0 0 1 1 1 0 Ndr family Peptidase_S9 PF00326.21 EMD65266.1 - 0.04 13.4 0.0 0.067 12.7 0.0 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family LIDHydrolase PF10230.9 EMD65266.1 - 0.11 12.1 0.2 0.32 10.5 0.2 1.7 1 1 0 1 1 1 0 Lipid-droplet associated hydrolase DUF1057 PF06342.12 EMD65266.1 - 0.17 10.9 0.0 4.6 6.2 0.0 2.1 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF1057) Cyt-b5 PF00173.28 EMD65267.1 - 2.9e-07 30.5 0.0 3.6e-07 30.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Amidohydro_1 PF01979.20 EMD65268.1 - 1.4e-06 27.8 3.7 1.8e-05 24.2 3.7 2.2 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EMD65268.1 - 2.4e-05 24.0 3.5 0.006 16.1 0.5 2.6 1 1 0 2 2 2 2 Amidohydrolase family Fungal_trans PF04082.18 EMD65269.1 - 1.2e-09 37.7 2.8 2e-09 36.9 2.8 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Phage-MuB_C PF09077.11 EMD65269.1 - 0.18 11.7 0.0 0.38 10.7 0.0 1.4 1 0 0 1 1 1 0 Mu B transposition protein, C terminal DUF3079 PF11278.8 EMD65270.1 - 0.0098 15.7 0.3 0.023 14.5 0.3 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3079) PDGF PF00341.17 EMD65270.1 - 0.14 12.4 0.5 0.53 10.6 0.5 2.0 1 0 0 1 1 1 0 PDGF/VEGF domain zf-primase PF09329.11 EMD65270.1 - 0.23 11.3 4.5 7.5 6.5 0.3 2.6 2 0 0 2 2 2 0 Primase zinc finger zf-C3Hc3H PF13891.6 EMD65270.1 - 8.8 6.8 7.7 26 5.3 1.2 3.0 2 1 1 3 3 3 0 Potential DNA-binding domain ECH_1 PF00378.20 EMD65272.1 - 1.7e-51 174.9 0.0 2.6e-51 174.4 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EMD65272.1 - 6.3e-25 88.4 0.1 6e-21 75.3 0.0 2.3 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase Peptidase_S49 PF01343.18 EMD65272.1 - 0.0013 18.7 0.0 0.32 10.9 0.0 2.2 2 0 0 2 2 2 2 Peptidase family S49 Myc-LZ PF02344.15 EMD65273.1 - 0.0012 18.9 0.1 0.003 17.6 0.1 1.7 1 0 0 1 1 1 1 Myc leucine zipper domain TolA_bind_tri PF16331.5 EMD65273.1 - 0.015 15.4 0.2 0.031 14.3 0.2 1.5 1 0 0 1 1 1 0 TolA binding protein trimerisation LUC7 PF03194.15 EMD65273.1 - 0.025 14.3 0.0 0.03 14.0 0.0 1.2 1 0 0 1 1 1 0 LUC7 N_terminus HALZ PF02183.18 EMD65273.1 - 0.064 13.5 0.1 0.13 12.5 0.1 1.5 1 0 0 1 1 1 0 Homeobox associated leucine zipper FlaC_arch PF05377.11 EMD65273.1 - 0.11 13.0 0.7 0.29 11.6 0.4 1.8 1 1 0 1 1 1 0 Flagella accessory protein C (FlaC) bZIP_1 PF00170.21 EMD65273.1 - 0.2 11.8 15.7 0.55 10.4 0.2 2.8 1 1 2 3 3 3 0 bZIP transcription factor DivIC PF04977.15 EMD65273.1 - 0.25 11.2 4.1 0.11 12.3 0.7 1.9 1 1 1 2 2 2 0 Septum formation initiator BST2 PF16716.5 EMD65273.1 - 0.33 11.6 4.2 0.66 10.6 4.2 1.4 1 0 0 1 1 1 0 Bone marrow stromal antigen 2 bZIP_2 PF07716.15 EMD65273.1 - 0.46 10.6 14.8 4.1 7.6 0.8 3.2 1 1 2 3 3 3 0 Basic region leucine zipper UCH PF00443.29 EMD65274.1 - 2.5e-44 151.7 0.0 4.8e-44 150.8 0.0 1.4 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EMD65274.1 - 2.9e-08 33.7 0.0 1.6e-06 28.0 0.0 2.3 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-C3HC4_2 PF13923.6 EMD65275.1 - 8.7e-08 31.9 3.7 2e-06 27.6 1.4 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMD65275.1 - 1.1e-07 31.6 6.0 1.8e-07 30.9 6.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EMD65275.1 - 7.2e-07 29.1 3.0 7.9e-07 29.0 1.8 1.7 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 EMD65275.1 - 1.3e-05 25.2 3.1 3.1e-05 24.0 3.1 1.7 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 EMD65275.1 - 2.1e-05 24.4 5.1 7.2e-05 22.7 5.3 1.8 1 1 1 2 2 2 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EMD65275.1 - 2.4e-05 24.1 4.9 4.6e-05 23.2 4.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EMD65275.1 - 2.9e-05 24.3 5.6 5.9e-05 23.3 5.6 1.6 1 0 0 1 1 1 1 Ring finger domain Ashwin PF15323.6 EMD65275.1 - 0.034 14.2 0.8 0.034 14.2 0.8 3.0 3 0 0 3 3 3 0 Developmental protein TerY_C PF15616.6 EMD65275.1 - 0.057 13.5 0.1 0.14 12.3 0.1 1.6 1 0 0 1 1 1 0 TerY-C metal binding domain zf-rbx1 PF12678.7 EMD65275.1 - 0.13 12.6 4.3 0.64 10.3 4.3 2.1 1 1 0 1 1 1 0 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 EMD65275.1 - 0.15 12.0 9.2 1.9 8.4 9.2 2.6 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 Rxt3 PF08642.10 EMD65275.1 - 0.21 12.4 1.9 5.1 7.9 0.0 3.1 3 0 0 3 3 3 0 Histone deacetylation protein Rxt3 SelK_SelG PF10961.8 EMD65276.1 - 0.24 12.1 11.8 3.1 8.5 11.8 2.0 1 1 0 1 1 1 0 Selenoprotein SelK_SelG Methyltrn_RNA_3 PF02598.17 EMD65277.1 - 1e-96 323.8 0.0 1.3e-96 323.5 0.0 1.1 1 0 0 1 1 1 1 Putative RNA methyltransferase UBA2_C PF16195.5 EMD65277.1 - 0.25 12.1 6.0 0.59 10.8 6.0 1.7 1 0 0 1 1 1 0 SUMO-activating enzyme subunit 2 C-terminus Cutinase PF01083.22 EMD65281.1 - 8.3e-42 143.1 2.3 1.1e-41 142.7 2.3 1.2 1 0 0 1 1 1 1 Cutinase PE-PPE PF08237.11 EMD65281.1 - 0.0033 17.0 0.1 0.0051 16.4 0.1 1.2 1 0 0 1 1 1 1 PE-PPE domain Hydrolase_4 PF12146.8 EMD65281.1 - 0.092 12.0 0.0 0.15 11.3 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EMD65281.1 - 0.093 12.4 0.0 1.5 8.4 0.0 2.0 1 1 0 2 2 2 0 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 EMD65281.1 - 0.093 12.5 0.0 0.2 11.4 0.0 1.5 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase FAD_binding_3 PF01494.19 EMD65282.1 - 1.2e-21 77.3 0.0 2e-21 76.6 0.0 1.3 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.24 EMD65282.1 - 1.9e-10 40.8 3.9 3.8e-05 23.4 2.1 2.2 1 1 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EMD65282.1 - 5.2e-08 32.4 0.6 7.7e-08 31.8 0.6 1.2 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 EMD65282.1 - 2.7e-07 29.6 0.4 2.4e-06 26.5 0.4 2.0 1 1 0 1 1 1 1 HI0933-like protein Pyr_redox_2 PF07992.14 EMD65282.1 - 1.2e-06 28.0 1.1 0.00048 19.5 0.4 2.2 1 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EMD65282.1 - 2e-06 27.4 0.2 2.6e-06 27.1 0.2 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EMD65282.1 - 1.9e-05 24.8 1.5 5.6e-05 23.3 1.5 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 EMD65282.1 - 2.7e-05 23.4 0.1 4e-05 22.9 0.1 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A Pyr_redox PF00070.27 EMD65282.1 - 0.00015 22.2 0.1 0.037 14.6 0.1 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EMD65282.1 - 0.0009 18.2 2.3 0.1 11.5 0.6 2.2 1 1 1 2 2 2 2 Tryptophan halogenase Amino_oxidase PF01593.24 EMD65282.1 - 0.0021 17.4 0.3 0.3 10.3 0.3 2.7 3 0 0 3 3 3 1 Flavin containing amine oxidoreductase SE PF08491.10 EMD65282.1 - 0.0027 16.8 0.0 0.0054 15.8 0.0 1.4 2 0 0 2 2 2 1 Squalene epoxidase Thi4 PF01946.17 EMD65282.1 - 0.0038 16.5 0.6 0.0062 15.8 0.6 1.2 1 0 0 1 1 1 1 Thi4 family Pyr_redox_3 PF13738.6 EMD65282.1 - 0.0042 16.4 0.0 0.012 14.9 0.1 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EMD65282.1 - 0.015 14.4 1.3 0.048 12.7 1.3 1.8 1 1 0 1 1 1 0 Lycopene cyclase protein 3HCDH_N PF02737.18 EMD65282.1 - 0.016 15.1 0.1 0.027 14.3 0.1 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 EMD65282.1 - 0.064 12.5 0.2 0.12 11.6 0.2 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain DUF2076 PF09849.9 EMD65284.1 - 2.7e-07 30.9 12.5 3.2e-07 30.6 12.5 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2076) CHCH PF06747.13 EMD65284.1 - 0.00039 20.5 1.6 0.0019 18.2 2.1 1.8 1 1 1 2 2 2 2 CHCH domain CX9C PF16860.5 EMD65284.1 - 0.013 15.5 0.5 0.02 14.9 0.5 1.2 1 0 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Antimicrobial24 PF16049.5 EMD65284.1 - 0.32 11.0 1.5 0.63 10.1 1.5 1.4 1 0 0 1 1 1 0 Frog antimicrobial peptide MSA-2c PF12238.8 EMD65284.1 - 2.4 8.1 10.1 4.2 7.3 10.1 1.4 1 0 0 1 1 1 0 Merozoite surface antigen 2c DLH PF01738.18 EMD65285.1 - 2.5e-26 92.6 0.0 3.2e-26 92.2 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family LIDHydrolase PF10230.9 EMD65285.1 - 0.023 14.3 0.0 0.029 13.9 0.0 1.1 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase LRR_4 PF12799.7 EMD65288.1 - 9.1e-15 54.5 3.7 4e-05 23.9 0.7 3.8 3 0 0 3 3 3 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EMD65288.1 - 1e-12 47.6 4.5 5.8e-08 32.4 3.0 3.6 2 1 1 3 3 3 3 Leucine rich repeat LRR_1 PF00560.33 EMD65288.1 - 0.00071 19.8 6.9 25 5.9 0.3 5.9 6 0 0 6 6 6 1 Leucine Rich Repeat LRR_9 PF14580.6 EMD65288.1 - 0.0061 16.1 1.4 0.33 10.4 0.1 2.2 1 1 1 2 2 2 2 Leucine-rich repeat LRR_6 PF13516.6 EMD65288.1 - 0.04 14.0 12.7 63 4.0 0.0 5.7 5 0 0 5 5 5 0 Leucine Rich repeat Metallophos PF00149.28 EMD65290.1 - 2.3e-40 139.3 0.1 3e-40 138.9 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EMD65290.1 - 5.6e-23 81.1 1.8 8.3e-23 80.6 1.1 1.7 2 0 0 2 2 2 1 Serine-threonine protein phosphatase N-terminal domain Sec2p PF06428.11 EMD65292.1 - 3.5e-24 84.6 10.2 3.5e-24 84.6 10.2 2.9 3 0 0 3 3 3 2 GDP/GTP exchange factor Sec2p Sas10_Utp3 PF04000.15 EMD65293.1 - 4.5e-13 49.6 0.4 4.5e-13 49.6 0.4 2.3 3 0 0 3 3 3 1 Sas10/Utp3/C1D family CENP-B_dimeris PF09026.10 EMD65293.1 - 8.6 6.8 12.7 3 8.3 4.3 2.4 2 0 0 2 2 2 0 Centromere protein B dimerisation domain ApbA_C PF08546.11 EMD65294.1 - 7e-33 113.5 0.3 1.2e-32 112.7 0.3 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.16 EMD65294.1 - 1.4e-20 73.5 0.0 3.2e-20 72.3 0.0 1.6 1 1 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Fructosamin_kin PF03881.14 EMD65295.1 - 1.3e-72 244.5 0.0 1.5e-72 244.2 0.0 1.0 1 0 0 1 1 1 1 Fructosamine kinase APH PF01636.23 EMD65295.1 - 0.0046 16.9 0.0 0.006 16.5 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 EMD65295.1 - 0.011 15.1 0.0 0.015 14.7 0.0 1.2 1 0 0 1 1 1 0 Ecdysteroid kinase Stm1_N PF09598.10 EMD65296.1 - 0.29 12.0 3.9 8.6 7.3 1.0 2.1 2 0 0 2 2 2 0 Stm1 PBP1_TM PF14812.6 EMD65296.1 - 8 6.9 9.2 6.7 7.2 7.1 1.9 1 1 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal FAD_binding_7 PF03441.14 EMD65297.1 - 3.2e-55 186.8 1.4 5.9e-55 185.9 1.4 1.5 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.18 EMD65297.1 - 1.1e-42 145.8 0.0 2.9e-42 144.5 0.0 1.7 1 0 0 1 1 1 1 DNA photolyase Baculo_LEF-3 PF05847.11 EMD65297.1 - 0.14 11.3 0.0 0.87 8.7 0.0 1.9 2 0 0 2 2 2 0 Nucleopolyhedrovirus late expression factor 3 (LEF-3) SSFA2_C PF14723.6 EMD65297.1 - 0.15 11.9 0.0 0.46 10.4 0.0 1.8 2 0 0 2 2 2 0 Sperm-specific antigen 2 C-terminus Alk_phosphatase PF00245.20 EMD65298.1 - 7.9e-78 262.2 0.0 2.1e-77 260.9 0.0 1.6 1 1 0 1 1 1 1 Alkaline phosphatase Phosphodiest PF01663.22 EMD65298.1 - 1.1e-05 25.2 0.1 1.7e-05 24.6 0.1 1.3 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 EMD65298.1 - 4.6e-05 23.0 0.2 0.00012 21.6 0.2 1.7 1 1 0 1 1 1 1 Sulfatase Metalloenzyme PF01676.18 EMD65298.1 - 0.0008 18.8 0.3 0.0047 16.3 0.1 2.1 2 0 0 2 2 2 1 Metalloenzyme superfamily DUF229 PF02995.17 EMD65298.1 - 0.014 14.0 0.2 0.023 13.3 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF229) GYF PF02213.16 EMD65298.1 - 0.076 12.7 0.0 0.25 11.0 0.0 1.8 1 0 0 1 1 1 0 GYF domain HsbA PF12296.8 EMD65298.1 - 0.12 12.7 0.2 9.1 6.7 0.1 2.5 2 0 0 2 2 2 0 Hydrophobic surface binding protein A PSI PF01437.25 EMD65299.1 - 0.057 14.0 0.5 0.12 12.9 0.5 1.5 1 0 0 1 1 1 0 Plexin repeat Phosducin PF02114.16 EMD65302.1 - 9.1e-10 37.9 0.0 1.1e-09 37.6 0.0 1.2 1 0 0 1 1 1 1 Phosducin bZIP_1 PF00170.21 EMD65303.1 - 6.9e-09 35.7 13.0 1.1e-08 35.1 13.0 1.3 1 0 0 1 1 1 1 bZIP transcription factor PAP1 PF08601.10 EMD65303.1 - 6.8e-06 26.1 0.1 6.8e-06 26.1 0.1 2.8 2 1 1 3 3 3 1 Transcription factor PAP1 SHE3 PF17078.5 EMD65303.1 - 0.004 16.9 4.8 0.0056 16.4 4.8 1.1 1 0 0 1 1 1 1 SWI5-dependent HO expression protein 3 bZIP_Maf PF03131.17 EMD65303.1 - 0.0077 16.7 11.5 0.012 16.1 11.5 1.3 1 0 0 1 1 1 1 bZIP Maf transcription factor bZIP_2 PF07716.15 EMD65303.1 - 0.0082 16.2 10.0 0.0082 16.2 10.0 1.8 1 1 1 2 2 2 1 Basic region leucine zipper DUF812 PF05667.11 EMD65303.1 - 0.0094 14.9 1.3 0.012 14.5 1.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF812) ADIP PF11559.8 EMD65303.1 - 0.016 15.3 9.2 0.025 14.6 9.2 1.2 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding FlaC_arch PF05377.11 EMD65303.1 - 0.025 14.9 0.3 0.043 14.2 0.3 1.4 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) V_ATPase_I PF01496.19 EMD65303.1 - 0.054 11.4 0.7 0.067 11.1 0.7 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family GvpL_GvpF PF06386.11 EMD65303.1 - 0.17 11.8 6.3 0.28 11.1 6.3 1.3 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF UPF0242 PF06785.11 EMD65303.1 - 0.19 11.9 2.8 0.27 11.3 2.8 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus PGBA_C PF15437.6 EMD65303.1 - 2.8 8.4 11.4 0.32 11.4 6.6 1.9 2 0 0 2 2 2 0 Plasminogen-binding protein pgbA C-terminal Sigma70_r4_2 PF08281.12 EMD65304.1 - 8.2e-05 22.2 0.1 0.00011 21.8 0.1 1.2 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_23 PF13384.6 EMD65304.1 - 0.016 15.0 0.0 0.022 14.5 0.0 1.2 1 0 0 1 1 1 0 Homeodomain-like domain Sigma70_r4 PF04545.16 EMD65304.1 - 0.027 14.0 0.0 0.038 13.5 0.0 1.3 1 0 0 1 1 1 0 Sigma-70, region 4 HTH_IclR PF09339.10 EMD65304.1 - 0.12 12.2 0.0 0.21 11.4 0.0 1.5 1 1 0 1 1 1 0 IclR helix-turn-helix domain HTH_29 PF13551.6 EMD65304.1 - 0.13 12.3 0.0 2.9 8.0 0.0 2.0 2 0 0 2 2 2 0 Winged helix-turn helix MFS_1 PF07690.16 EMD65305.1 - 4.3e-32 111.4 52.0 1.1e-26 93.7 28.3 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EMD65305.1 - 1.2e-18 67.3 23.9 2.2e-14 53.2 5.7 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter LacAB_rpiB PF02502.18 EMD65305.1 - 0.18 11.8 0.7 0.33 10.9 0.7 1.3 1 0 0 1 1 1 0 Ribose/Galactose Isomerase WD40 PF00400.32 EMD65306.1 - 2.1e-18 66.3 8.1 0.00079 20.2 0.0 6.4 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD65306.1 - 2.1e-17 63.2 0.1 9.6e-05 22.6 0.0 5.6 2 2 3 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Coatomer_WDAD PF04053.14 EMD65306.1 - 2.1e-06 27.0 0.1 0.049 12.7 0.1 2.9 2 1 1 3 3 3 2 Coatomer WD associated region eIF2A PF08662.11 EMD65306.1 - 2.3e-06 27.7 0.5 0.021 14.7 0.1 3.3 2 1 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 EMD65306.1 - 0.0036 17.2 3.1 0.62 10.1 0.2 4.0 3 0 0 3 3 3 1 WD40-like Beta Propeller Repeat RWD PF05773.22 EMD65307.1 - 0.0037 17.5 0.1 0.068 13.5 0.1 2.5 1 1 0 1 1 1 1 RWD domain FAD_binding_4 PF01565.23 EMD65308.1 - 5.5e-36 123.4 4.9 1.1e-35 122.4 4.9 1.5 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EMD65308.1 - 3e-08 33.6 0.2 6.2e-08 32.6 0.2 1.5 1 0 0 1 1 1 1 Berberine and berberine like Cytokin-bind PF09265.10 EMD65308.1 - 0.058 12.8 0.0 0.089 12.2 0.0 1.3 1 0 0 1 1 1 0 Cytokinin dehydrogenase 1, FAD and cytokinin binding Rsm22 PF09243.10 EMD65309.1 - 1.2e-28 100.2 0.0 3.5e-20 72.4 0.0 2.8 2 1 0 2 2 2 2 Mitochondrial small ribosomal subunit Rsm22 adh_short PF00106.25 EMD65310.1 - 4.1e-05 23.1 0.0 5.2e-05 22.8 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD65310.1 - 0.00029 20.5 0.0 0.00033 20.3 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase PH PF00169.29 EMD65311.1 - 0.00028 21.3 0.0 0.00081 19.9 0.0 1.8 1 1 0 1 1 1 1 PH domain PH_9 PF15410.6 EMD65311.1 - 0.00062 20.1 0.0 0.002 18.5 0.0 1.8 2 0 0 2 2 2 1 Pleckstrin homology domain SCO1-SenC PF02630.14 EMD65313.1 - 1.9e-48 163.8 0.0 2.9e-48 163.2 0.0 1.3 1 0 0 1 1 1 1 SCO1/SenC AhpC-TSA PF00578.21 EMD65313.1 - 0.00051 20.0 0.0 0.0016 18.4 0.0 1.9 1 1 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EMD65313.1 - 0.033 13.9 0.1 0.35 10.6 0.1 2.2 1 1 0 1 1 1 0 Redoxin Thioredoxin_8 PF13905.6 EMD65313.1 - 0.058 13.7 0.0 0.12 12.8 0.0 1.6 1 1 0 1 1 1 0 Thioredoxin-like NCE101 PF11654.8 EMD65313.1 - 0.1 12.3 0.1 0.24 11.1 0.1 1.6 1 0 0 1 1 1 0 Non-classical export protein 1 JHY PF15261.6 EMD65313.1 - 0.14 12.9 0.8 1.2 9.8 0.3 2.0 2 0 0 2 2 2 0 Jhy protein AKAP28 PF14469.6 EMD65313.1 - 0.16 11.7 0.2 10 5.9 0.0 2.3 2 0 0 2 2 2 0 28 kDa A-kinase anchor DDE_3 PF13358.6 EMD65316.1 - 8e-06 25.7 1.0 8e-06 25.7 1.0 1.4 2 0 0 2 2 2 1 DDE superfamily endonuclease dsDNA_bind PF01984.20 EMD65319.1 - 1.5e-38 131.4 15.4 2.3e-38 130.9 15.4 1.2 1 0 0 1 1 1 1 Double-stranded DNA-binding domain DUF4615 PF15393.6 EMD65319.1 - 0.16 12.6 0.3 0.16 12.6 0.3 1.7 1 1 0 2 2 2 0 Domain of unknown function (DUF4615) ATP-synt_D PF01813.17 EMD65320.1 - 0.013 15.3 0.4 0.04 13.7 0.4 1.9 1 1 0 1 1 1 0 ATP synthase subunit D NYD-SP28_assoc PF14775.6 EMD65320.1 - 0.031 14.4 0.4 0.068 13.3 0.4 1.6 1 0 0 1 1 1 0 Sperm tail C-terminal domain YnfE PF17452.2 EMD65320.1 - 3.5 8.0 6.6 3.6 7.9 0.1 3.1 3 1 0 3 3 3 0 Uncharacterized YnfE-like RP-C_C PF11800.8 EMD65320.1 - 5.7 7.0 7.8 14 5.7 7.7 1.7 1 1 0 1 1 1 0 Replication protein C C-terminal region Fib_alpha PF08702.10 EMD65320.1 - 7.8 6.7 9.4 1.1 9.4 0.7 2.6 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family SURF1 PF02104.15 EMD65321.1 - 7.6e-40 137.0 0.0 9.6e-40 136.7 0.0 1.1 1 0 0 1 1 1 1 SURF1 family CMS1 PF14617.6 EMD65322.1 - 9.2e-70 234.8 2.8 1.1e-69 234.6 2.8 1.0 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit DEAD PF00270.29 EMD65322.1 - 0.00029 20.7 0.3 0.00047 20.0 0.1 1.4 1 1 0 1 1 1 1 DEAD/DEAH box helicase SWIRM-assoc_2 PF16496.5 EMD65322.1 - 0.012 14.5 2.9 0.017 14.0 2.9 1.1 1 0 0 1 1 1 0 SWIRM-associated domain at the N-terminal FoP_duplication PF13865.6 EMD65322.1 - 0.044 14.3 5.0 0.084 13.4 5.0 1.3 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 SPT6_acidic PF14632.6 EMD65322.1 - 0.092 13.3 7.1 0.2 12.3 7.1 1.5 1 0 0 1 1 1 0 Acidic N-terminal SPT6 TMEM214 PF10151.9 EMD65322.1 - 0.22 10.0 2.7 0.33 9.4 2.7 1.2 1 0 0 1 1 1 0 TMEM214, C-terminal, caspase 4 activator Ras PF00071.22 EMD65324.1 - 6.5e-54 181.9 0.0 7.6e-54 181.7 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMD65324.1 - 1.4e-20 73.7 0.0 2.3e-20 73.0 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMD65324.1 - 1.7e-07 30.9 0.0 2.3e-07 30.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EMD65324.1 - 0.0035 16.9 0.0 0.0084 15.7 0.0 1.6 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain UBX PF00789.20 EMD65325.1 - 1e-08 35.3 0.0 2.3e-08 34.1 0.0 1.6 1 0 0 1 1 1 1 UBX domain BBS2_C PF14782.6 EMD65325.1 - 0.1 11.3 1.2 0.15 10.8 1.2 1.1 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 2, C-terminal Vfa1 PF08432.10 EMD65325.1 - 0.14 12.5 8.9 0.23 11.8 8.9 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Ribosomal_S14 PF00253.21 EMD65327.1 - 3.2e-20 71.6 1.0 4.7e-20 71.1 0.4 1.6 2 0 0 2 2 2 1 Ribosomal protein S14p/S29e Spc29 PF17082.5 EMD65328.1 - 0.0057 16.5 0.1 0.013 15.3 0.1 1.6 1 0 0 1 1 1 1 Spindle Pole Component 29 DUF305 PF03713.13 EMD65328.1 - 0.098 12.8 0.2 0.25 11.5 0.1 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF305) Collagen PF01391.18 EMD65329.1 - 2.3e-21 75.3 86.4 8.4e-06 25.5 10.5 7.2 6 1 1 7 7 7 6 Collagen triple helix repeat (20 copies) EI24 PF07264.11 EMD65330.1 - 2.8e-15 57.0 2.7 4.4e-15 56.4 2.7 1.3 1 1 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) AAA_12 PF13087.6 EMD65331.1 - 9.4e-09 35.2 0.1 7.6e-08 32.2 0.0 2.0 2 0 0 2 2 2 1 AAA domain Arb1 PF09692.10 EMD65331.1 - 0.0099 15.1 0.0 0.015 14.5 0.0 1.2 1 0 0 1 1 1 1 Argonaute siRNA chaperone (ARC) complex subunit Arb1 SIP1 PF04938.12 EMD65332.1 - 6e-14 52.3 0.0 8.1e-13 48.6 0.0 2.3 2 0 0 2 2 2 1 Survival motor neuron (SMN) interacting protein 1 (SIP1) Cytochrom_C PF00034.21 EMD65332.1 - 0.11 13.6 0.5 0.72 11.0 0.0 2.6 2 0 0 2 2 2 0 Cytochrome c RAG1_imp_bd PF12560.8 EMD65332.1 - 0.36 10.3 3.4 0.17 11.4 0.2 2.0 2 0 0 2 2 2 0 RAG1 importin binding Mito_fiss_reg PF05308.11 EMD65332.1 - 1.9 8.5 10.2 8.5 6.4 3.6 2.4 2 0 0 2 2 2 0 Mitochondrial fission regulator tRNA-synt_His PF13393.6 EMD65333.1 - 2.9e-45 154.9 0.0 3.7e-45 154.5 0.0 1.1 1 0 0 1 1 1 1 Histidyl-tRNA synthetase HGTP_anticodon PF03129.20 EMD65333.1 - 8.3e-14 51.5 0.2 1.9e-13 50.3 0.1 1.7 2 0 0 2 2 2 1 Anticodon binding domain tRNA-synt_2 PF00152.20 EMD65333.1 - 0.0003 20.0 0.0 0.0029 16.7 0.0 2.2 1 1 0 1 1 1 1 tRNA synthetases class II (D, K and N) HGTP_anticodon2 PF12745.7 EMD65333.1 - 0.0028 17.2 0.0 0.0041 16.7 0.0 1.2 1 0 0 1 1 1 1 Anticodon binding domain of tRNAs B12D PF06522.11 EMD65334.1 - 0.12 12.2 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 NADH-ubiquinone reductase complex 1 MLRQ subunit DHHC PF01529.20 EMD65335.1 - 6.2e-36 123.5 7.1 1.4e-35 122.3 7.1 1.5 1 0 0 1 1 1 1 DHHC palmitoyltransferase SET PF00856.28 EMD65336.1 - 2.4e-15 57.3 0.2 2.4e-15 57.3 0.2 3.4 3 2 0 3 3 3 1 SET domain AWS PF17907.1 EMD65336.1 - 3.5e-07 30.1 5.6 3.5e-07 30.1 5.6 2.4 2 0 0 2 2 2 1 AWS domain Raptor_N PF14538.6 EMD65337.1 - 1.7e-65 219.4 0.0 3.6e-65 218.4 0.0 1.6 1 0 0 1 1 1 1 Raptor N-terminal CASPase like domain WD40 PF00400.32 EMD65337.1 - 8.5e-06 26.4 8.1 1.4 9.9 0.0 6.0 7 0 0 7 7 7 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD65337.1 - 6.3e-05 23.2 0.1 4.6 7.6 0.0 4.3 2 1 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 EMD65337.1 - 0.00023 21.2 0.2 0.087 12.9 0.0 2.8 1 1 1 2 2 2 2 Ciliary BBSome complex subunit 2, middle region Atx10homo_assoc PF09759.9 EMD65337.1 - 0.0058 16.6 0.4 0.011 15.7 0.4 1.4 1 0 0 1 1 1 1 Spinocerebellar ataxia type 10 protein domain HEAT PF02985.22 EMD65337.1 - 0.065 13.5 4.2 10 6.7 0.1 4.6 5 0 0 5 5 5 0 HEAT repeat tRNA-synt_2 PF00152.20 EMD65338.1 - 1e-72 244.9 0.0 1.3e-72 244.5 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EMD65338.1 - 0.00012 22.0 0.1 0.0002 21.3 0.1 1.3 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 EMD65338.1 - 0.017 14.6 0.1 2 7.8 0.1 2.7 3 0 0 3 3 3 0 tRNA synthetases class II core domain (F) Rrp40_N PF18311.1 EMD65339.1 - 1.9e-15 56.5 0.1 4e-15 55.5 0.1 1.5 1 0 0 1 1 1 1 Exosome complex exonuclease Rrp40 N-terminal domain KH_6 PF15985.5 EMD65339.1 - 1.6e-14 54.0 0.4 2.7e-14 53.3 0.4 1.4 1 0 0 1 1 1 1 KH domain HSP70 PF00012.20 EMD65340.1 - 1.6e-77 261.1 0.5 1.6e-77 261.1 0.5 1.4 1 1 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EMD65340.1 - 6e-08 31.9 0.1 9.1e-08 31.3 0.1 1.3 1 0 0 1 1 1 1 MreB/Mbl protein Cwf_Cwc_15 PF04889.12 EMD65340.1 - 0.019 14.7 3.5 0.036 13.8 3.5 1.4 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DUF3221 PF11518.8 EMD65340.1 - 0.049 14.0 1.7 0.12 12.8 1.7 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3221) FAM176 PF14851.6 EMD65340.1 - 0.1 12.2 2.1 0.19 11.4 2.1 1.4 1 0 0 1 1 1 0 FAM176 family PI3K_1B_p101 PF10486.9 EMD65340.1 - 0.18 9.6 0.1 0.25 9.1 0.1 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit DNA_pol_phi PF04931.13 EMD65340.1 - 1.9 6.5 5.1 2.8 5.9 5.1 1.1 1 0 0 1 1 1 0 DNA polymerase phi NOA36 PF06524.12 EMD65340.1 - 3.9 6.7 5.0 6.5 6.0 5.0 1.2 1 0 0 1 1 1 0 NOA36 protein F-box-like PF12937.7 EMD65341.1 - 0.00028 20.7 0.5 0.00067 19.5 0.2 1.9 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EMD65341.1 - 0.022 14.7 0.1 0.088 12.7 0.1 2.0 1 0 0 1 1 1 0 F-box domain LRR_4 PF12799.7 EMD65341.1 - 0.061 13.8 1.9 0.83 10.2 0.4 3.6 3 1 1 4 4 4 0 Leucine Rich repeats (2 copies) Lactonase PF10282.9 EMD65342.1 - 1.8e-64 218.2 0.2 2.2e-64 217.9 0.2 1.0 1 0 0 1 1 1 1 Lactonase, 7-bladed beta-propeller Hydrolase_6 PF13344.6 EMD65343.1 - 6.9e-24 83.9 0.0 8.3e-23 80.4 0.0 2.3 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EMD65343.1 - 1.5e-18 66.6 0.1 5.8e-18 64.7 0.0 2.0 2 0 0 2 2 2 1 HAD-hyrolase-like Hydrolase PF00702.26 EMD65343.1 - 0.00031 21.1 0.0 2.4 8.4 0.0 3.4 3 1 0 3 3 3 2 haloacid dehalogenase-like hydrolase zf-3CxxC PF13695.6 EMD65344.1 - 3e-21 75.8 0.9 3e-21 75.8 0.9 2.4 2 1 0 2 2 2 1 Zinc-binding domain zf-C2H2_jaz PF12171.8 EMD65344.1 - 4.6e-12 45.9 3.4 4.3e-05 23.7 1.2 2.7 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2_3rep PF18868.1 EMD65344.1 - 0.00034 21.3 2.6 0.081 13.6 0.7 2.6 1 1 1 2 2 2 2 Zinc finger C2H2-type, 3 repeats zf-C2H2_2 PF12756.7 EMD65344.1 - 0.012 15.9 5.0 2.5 8.5 1.8 2.8 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf_C2H2_ZHX PF18387.1 EMD65344.1 - 0.027 14.1 3.4 0.51 10.0 0.8 2.6 1 1 1 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain ESAG1 PF03238.13 EMD65344.1 - 0.065 12.7 0.3 0.099 12.1 0.3 1.3 1 0 0 1 1 1 0 ESAG protein zf-met PF12874.7 EMD65344.1 - 0.31 11.5 0.0 0.31 11.5 0.0 4.3 5 0 0 5 5 5 0 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 EMD65344.1 - 0.32 11.9 12.8 0.72 10.9 0.1 4.1 4 0 0 4 4 4 0 C2H2-type zinc finger zf-3CxxC_2 PF17180.4 EMD65344.1 - 0.33 11.7 14.7 0.64 10.8 1.2 4.2 3 2 0 3 3 3 0 Zinc-binding domain zf-LYAR PF08790.11 EMD65344.1 - 0.68 9.9 7.1 2 8.4 0.1 3.0 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger DUF5321 PF17254.2 EMD65346.1 - 6.7e-61 204.4 3.1 8.2e-61 204.1 3.1 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5321) Moulting_cycle PF04870.16 EMD65346.1 - 0.11 11.7 3.6 0.16 11.2 3.6 1.1 1 0 0 1 1 1 0 Moulting cycle 4HBT PF03061.22 EMD65347.1 - 9.9e-09 35.4 0.1 1.7e-08 34.7 0.1 1.4 1 0 0 1 1 1 1 Thioesterase superfamily Vps5 PF09325.10 EMD65348.1 - 1.6e-88 296.2 5.9 2.7e-88 295.5 5.9 1.3 1 0 0 1 1 1 1 Vps5 C terminal like PX PF00787.24 EMD65348.1 - 1.2e-25 89.6 0.0 2.9e-25 88.5 0.0 1.6 1 0 0 1 1 1 1 PX domain BAR_3 PF16746.5 EMD65348.1 - 0.023 14.4 5.3 0.23 11.1 1.9 2.3 1 1 1 2 2 2 0 BAR domain of APPL family BAR_2 PF10455.9 EMD65348.1 - 0.055 12.6 5.8 0.13 11.3 5.7 1.6 1 1 0 1 1 1 0 Bin/amphiphysin/Rvs domain for vesicular trafficking BAR PF03114.18 EMD65348.1 - 0.64 9.6 8.1 0.93 9.1 7.2 1.5 1 1 0 1 1 1 0 BAR domain DUF713 PF05218.14 EMD65348.1 - 1.1 9.0 4.7 1.5 8.6 0.4 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF713) Glyco_hydro_43 PF04616.14 EMD65349.1 - 6.9e-104 347.2 1.1 6.9e-104 347.2 1.1 2.0 2 0 0 2 2 2 1 Glycosyl hydrolases family 43 GH43_C2 PF17851.1 EMD65349.1 - 7.2e-46 156.5 0.0 1e-45 155.9 0.0 1.2 1 0 0 1 1 1 1 Beta xylosidase C-terminal Concanavalin A-like domain Glyco_hydro_32N PF00251.20 EMD65349.1 - 0.0014 18.3 0.3 0.0039 16.8 0.3 1.7 1 1 1 2 2 2 2 Glycosyl hydrolases family 32 N-terminal domain DUF4349 PF14257.6 EMD65350.1 - 0.61 9.5 8.6 2.9 7.3 0.1 3.3 2 1 1 3 3 3 0 Domain of unknown function (DUF4349) His_Phos_2 PF00328.22 EMD65351.1 - 5.7e-23 81.9 0.0 7.7e-23 81.5 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Hanta_G1 PF01567.16 EMD65351.1 - 0.1 11.3 0.0 0.15 10.8 0.0 1.1 1 0 0 1 1 1 0 Hantavirus glycoprotein G1 DUF1798 PF08807.10 EMD65351.1 - 0.16 12.1 0.0 0.27 11.4 0.0 1.3 1 0 0 1 1 1 0 Bacterial domain of unknown function (DUF1798) Amino_oxidase PF01593.24 EMD65352.1 - 2.8e-18 66.5 0.0 3.7e-17 62.8 0.0 2.1 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EMD65352.1 - 1.2e-12 47.9 0.1 3.3e-12 46.4 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EMD65352.1 - 7.6e-08 31.9 0.0 1.6e-07 30.9 0.0 1.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EMD65352.1 - 1.3e-07 31.5 0.1 6.8e-07 29.2 0.1 2.1 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EMD65352.1 - 1.7e-05 24.1 3.6 0.00041 19.6 5.5 2.0 2 0 0 2 2 2 1 FAD binding domain FAD_oxidored PF12831.7 EMD65352.1 - 5.2e-05 22.8 1.6 0.0013 18.2 3.3 1.9 2 0 0 2 2 2 1 FAD dependent oxidoreductase HI0933_like PF03486.14 EMD65352.1 - 0.00019 20.2 0.7 0.0014 17.5 1.6 1.9 2 0 0 2 2 2 1 HI0933-like protein FAD_binding_3 PF01494.19 EMD65352.1 - 0.00028 20.2 0.4 0.00079 18.8 0.7 1.5 2 0 0 2 2 2 1 FAD binding domain Pyr_redox PF00070.27 EMD65352.1 - 0.00043 20.8 4.3 0.001 19.6 2.5 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase 2-Hacid_dh_C PF02826.19 EMD65352.1 - 0.00095 18.6 0.3 0.055 12.8 0.3 2.2 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ApbA PF02558.16 EMD65352.1 - 0.00095 18.8 0.3 0.0018 18.0 0.3 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Lycopene_cycl PF05834.12 EMD65352.1 - 0.0022 17.1 2.0 0.012 14.7 1.7 1.9 2 0 0 2 2 2 1 Lycopene cyclase protein NAD_binding_9 PF13454.6 EMD65352.1 - 0.0037 17.2 0.4 0.025 14.6 0.3 2.3 2 0 0 2 2 2 1 FAD-NAD(P)-binding NAD_binding_7 PF13241.6 EMD65352.1 - 0.0041 17.5 0.0 0.0077 16.6 0.0 1.5 1 0 0 1 1 1 1 Putative NAD(P)-binding Pyr_redox_3 PF13738.6 EMD65352.1 - 0.0076 15.5 2.4 0.016 14.5 2.4 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.18 EMD65352.1 - 0.014 15.6 0.1 0.029 14.6 0.1 1.5 1 0 0 1 1 1 0 TrkA-N domain GDI PF00996.18 EMD65352.1 - 0.023 13.2 0.0 1.8 7.0 0.0 2.1 2 0 0 2 2 2 0 GDP dissociation inhibitor Thi4 PF01946.17 EMD65352.1 - 0.024 13.9 1.2 0.041 13.1 1.2 1.2 1 0 0 1 1 1 0 Thi4 family XdhC_C PF13478.6 EMD65352.1 - 0.065 13.7 0.0 0.18 12.3 0.0 1.8 2 0 0 2 2 2 0 XdhC Rossmann domain 3HCDH_N PF02737.18 EMD65352.1 - 0.086 12.7 1.4 0.17 11.8 1.4 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ThiF PF00899.21 EMD65352.1 - 0.096 12.0 0.7 0.16 11.3 0.7 1.2 1 0 0 1 1 1 0 ThiF family NAD_Gly3P_dh_N PF01210.23 EMD65352.1 - 0.11 12.5 0.3 0.45 10.5 0.2 1.9 2 0 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus GIDA PF01134.22 EMD65352.1 - 0.13 11.3 2.6 0.2 10.7 2.6 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A adh_short PF00106.25 EMD65352.1 - 0.31 10.4 1.2 0.54 9.7 1.2 1.3 1 0 0 1 1 1 0 short chain dehydrogenase Trp_halogenase PF04820.14 EMD65352.1 - 0.46 9.3 1.7 0.68 8.7 1.7 1.2 1 0 0 1 1 1 0 Tryptophan halogenase Bac_rhodopsin PF01036.18 EMD65353.1 - 1.8e-57 194.5 14.7 2.2e-57 194.2 14.7 1.0 1 0 0 1 1 1 1 Bacteriorhodopsin-like protein DUF4131 PF13567.6 EMD65353.1 - 0.062 12.9 4.5 1.4 8.5 1.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) Saf_2TM PF18303.1 EMD65353.1 - 0.76 9.4 3.5 4.6 6.8 0.0 3.1 2 1 1 3 3 3 0 SAVED-fused 2TM effector domain DUF1772 PF08592.11 EMD65353.1 - 2.8 8.3 6.5 0.26 11.6 1.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1772) DUF3810 PF12725.7 EMD65353.1 - 5 6.4 9.6 6.5 6.0 0.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3810) RPE65 PF03055.15 EMD65354.1 - 3.4e-116 389.2 0.0 4e-116 389.0 0.0 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein SQS_PSY PF00494.19 EMD65355.1 - 4.8e-66 222.9 1.1 6.1e-66 222.6 1.1 1.1 1 0 0 1 1 1 1 Squalene/phytoene synthase GPI2 PF06432.11 EMD65356.1 - 2.8e-119 397.7 9.7 3.1e-119 397.6 9.7 1.0 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase F-box-like_2 PF13013.6 EMD65357.1 - 0.086 12.8 0.2 0.14 12.1 0.2 1.4 1 0 0 1 1 1 0 F-box-like domain Annexin PF00191.20 EMD65358.1 - 2.5e-23 81.9 1.5 1.6e-05 24.9 0.0 4.4 4 0 0 4 4 4 4 Annexin Myb_DNA-binding PF00249.31 EMD65359.1 - 1.2e-12 47.8 0.0 1.4e-07 31.6 0.0 2.6 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EMD65359.1 - 2.4e-07 30.9 0.0 0.0072 16.5 0.0 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain SLIDE PF09111.10 EMD65359.1 - 0.00024 21.1 0.0 0.01 15.8 0.0 2.4 2 0 0 2 2 2 1 SLIDE AhpC-TSA PF00578.21 EMD65360.1 - 3.7e-33 114.1 0.0 4.9e-33 113.7 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family 1-cysPrx_C PF10417.9 EMD65360.1 - 4.5e-16 58.4 0.1 7.7e-16 57.7 0.1 1.4 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin Redoxin PF08534.10 EMD65360.1 - 1.3e-14 54.1 0.0 1.7e-14 53.8 0.0 1.1 1 0 0 1 1 1 1 Redoxin Acatn PF13000.7 EMD65361.1 - 3.9e-161 537.3 17.6 4.2e-85 286.3 7.4 3.2 1 1 2 3 3 3 3 Acetyl-coenzyme A transporter 1 CENP-O PF09496.10 EMD65362.1 - 1.2e-57 195.3 1.0 3.4e-57 193.9 0.0 1.9 2 0 0 2 2 2 1 Cenp-O kinetochore centromere component TSC22 PF01166.18 EMD65362.1 - 0.03 14.6 0.2 0.53 10.6 0.0 2.7 3 1 0 3 3 3 0 TSC-22/dip/bun family YabA PF06156.13 EMD65362.1 - 0.14 12.8 0.3 0.28 11.8 0.3 1.4 1 0 0 1 1 1 0 Initiation control protein YabA APG6_N PF17675.1 EMD65362.1 - 0.19 12.2 0.9 0.35 11.4 0.9 1.4 1 0 0 1 1 1 0 Apg6 coiled-coil region TMF_TATA_bd PF12325.8 EMD65362.1 - 0.23 11.7 3.0 0.25 11.6 1.7 1.7 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding Glyco_hydro_18 PF00704.28 EMD65365.1 - 3.9e-83 279.8 6.4 4.5e-83 279.6 6.4 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 LIAS_N PF16881.5 EMD65366.1 - 7.2e-20 71.4 0.0 1.5e-19 70.4 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of lipoyl synthase of Radical_SAM family Radical_SAM PF04055.21 EMD65366.1 - 3.1e-13 50.4 0.0 4.8e-13 49.8 0.0 1.3 1 0 0 1 1 1 1 Radical SAM superfamily UBA_5 PF16577.5 EMD65366.1 - 0.012 15.8 0.0 0.031 14.4 0.0 1.7 1 0 0 1 1 1 0 UBA domain Adaptin_N PF01602.20 EMD65367.1 - 3.7e-114 382.1 0.0 5.1e-114 381.7 0.0 1.1 1 0 0 1 1 1 1 Adaptin N terminal region COP-gamma_platf PF08752.10 EMD65367.1 - 4e-56 189.4 3.3 8.1e-56 188.4 3.3 1.6 1 0 0 1 1 1 1 Coatomer gamma subunit appendage platform subdomain Coatomer_g_Cpla PF16381.5 EMD65367.1 - 1.6e-34 118.4 0.2 5.1e-34 116.8 0.2 1.9 1 0 0 1 1 1 1 Coatomer subunit gamma-1 C-terminal appendage platform HEAT_2 PF13646.6 EMD65367.1 - 1.1e-18 67.4 0.9 6.7e-10 39.2 0.0 5.9 2 1 4 6 6 6 4 HEAT repeats Cnd1 PF12717.7 EMD65367.1 - 1.3e-06 28.6 10.3 0.091 12.8 0.1 4.6 4 1 1 5 5 5 3 non-SMC mitotic condensation complex subunit 1 HEAT_PBS PF03130.16 EMD65367.1 - 0.01 16.4 0.7 10 7.1 0.0 4.8 5 0 0 5 5 5 0 PBS lyase HEAT-like repeat Coatomer_b_Cpla PF14806.6 EMD65367.1 - 0.14 12.1 0.0 0.82 9.7 0.0 2.1 2 0 0 2 2 2 0 Coatomer beta subunit appendage platform HEAT PF02985.22 EMD65367.1 - 0.25 11.7 11.4 3.3 8.2 0.3 6.2 7 0 0 7 7 7 0 HEAT repeat SET PF00856.28 EMD65368.1 - 2.5e-13 50.8 0.0 4.4e-13 50.0 0.0 1.4 1 0 0 1 1 1 1 SET domain Coq4 PF05019.13 EMD65369.1 - 1.9e-94 315.1 0.0 2.5e-94 314.8 0.0 1.1 1 0 0 1 1 1 1 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 ATP-sulfurylase PF01747.17 EMD65370.1 - 1.1e-88 296.2 0.0 1.8e-88 295.5 0.0 1.3 1 0 0 1 1 1 1 ATP-sulfurylase APS_kinase PF01583.20 EMD65370.1 - 3.9e-56 189.3 0.0 6.7e-56 188.6 0.0 1.4 1 0 0 1 1 1 1 Adenylylsulphate kinase PUA_2 PF14306.6 EMD65370.1 - 7.2e-55 185.0 0.0 1.2e-54 184.3 0.0 1.4 1 0 0 1 1 1 1 PUA-like domain PAPS_reduct PF01507.19 EMD65371.1 - 2.4e-43 148.2 0.0 3.5e-43 147.7 0.0 1.2 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family Amidohydro_2 PF04909.14 EMD65372.1 - 1.2e-13 51.6 0.8 2e-13 50.8 0.8 1.4 1 1 0 1 1 1 1 Amidohydrolase PfkB PF00294.24 EMD65373.1 - 3.8e-17 62.5 0.0 9.6e-16 57.9 0.0 2.0 1 1 0 1 1 1 1 pfkB family carbohydrate kinase TMEM51 PF15345.6 EMD65374.1 - 0.044 13.6 0.0 0.063 13.1 0.0 1.2 1 0 0 1 1 1 0 Transmembrane protein 51 BRI3BP PF14965.6 EMD65374.1 - 0.81 9.2 3.8 1.7 8.1 3.8 1.5 1 0 0 1 1 1 0 Negative regulator of p53/TP53 NAD_binding_1 PF00175.21 EMD65375.1 - 6.5e-07 30.0 0.0 0.015 15.9 0.0 2.5 2 0 0 2 2 2 2 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 EMD65375.1 - 0.00059 20.0 0.0 0.92 9.6 0.0 2.2 2 0 0 2 2 2 2 Ferric reductase NAD binding domain Hydrolase_4 PF12146.8 EMD65376.1 - 5.8e-54 182.9 0.0 6.8e-54 182.7 0.0 1.0 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EMD65376.1 - 1.7e-14 54.1 0.1 5.3e-14 52.5 0.0 1.7 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EMD65376.1 - 7.5e-14 52.9 0.0 9.8e-14 52.5 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family DLH PF01738.18 EMD65376.1 - 0.00016 21.3 0.0 0.095 12.2 0.0 2.2 2 0 0 2 2 2 2 Dienelactone hydrolase family Peptidase_S9 PF00326.21 EMD65376.1 - 0.00032 20.3 0.0 0.53 9.7 0.0 2.6 2 1 1 3 3 3 2 Prolyl oligopeptidase family DUF1749 PF08538.10 EMD65376.1 - 0.0028 16.8 0.0 0.0039 16.3 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1749) DUF900 PF05990.12 EMD65376.1 - 0.023 14.2 0.0 0.036 13.6 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) Abhydrolase_3 PF07859.13 EMD65376.1 - 0.038 13.9 0.0 0.064 13.1 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold Esterase PF00756.20 EMD65376.1 - 0.079 12.6 0.0 0.16 11.6 0.0 1.5 2 0 0 2 2 2 0 Putative esterase Cation_efflux PF01545.21 EMD65377.1 - 8.5e-53 179.0 2.6 1.1e-52 178.7 2.6 1.1 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 EMD65377.1 - 3e-05 24.0 0.1 6.4e-05 23.0 0.1 1.5 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter UPF0147 PF03685.13 EMD65377.1 - 0.0099 15.9 0.7 0.019 15.0 0.0 1.7 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0147) FGGY_C PF02782.16 EMD65378.1 - 4.1e-29 101.7 0.0 6.6e-29 101.1 0.0 1.3 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 EMD65378.1 - 8.9e-18 64.7 0.0 7.3e-12 45.4 0.0 2.3 2 0 0 2 2 2 2 FGGY family of carbohydrate kinases, N-terminal domain ATP-synt_DE_N PF02823.16 EMD65379.1 - 9.6e-18 63.9 0.1 2.2e-17 62.7 0.1 1.6 1 1 0 1 1 1 1 ATP synthase, Delta/Epsilon chain, beta-sandwich domain DASH_Spc19 PF08287.11 EMD65380.1 - 1.9e-51 174.1 1.5 1.9e-51 174.1 1.5 1.4 2 0 0 2 2 2 1 Spc19 ATP-synt_J PF04911.12 EMD65381.1 - 3.2e-27 93.8 1.1 3.5e-27 93.7 1.1 1.0 1 0 0 1 1 1 1 ATP synthase j chain Pkinase PF00069.25 EMD65382.1 - 2.2e-26 92.8 0.0 2.7e-26 92.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD65382.1 - 6e-14 52.0 0.0 8.2e-14 51.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EMD65382.1 - 4.1e-09 35.7 0.0 5.9e-09 35.2 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EMD65382.1 - 0.00016 21.7 0.0 0.0015 18.5 0.0 2.1 1 1 0 2 2 2 1 Phosphotransferase enzyme family DUF1923 PF09083.10 EMD65382.1 - 0.1 12.3 0.0 0.24 11.1 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1923) HLH PF00010.26 EMD65383.1 - 3.7e-14 52.4 0.5 8.5e-14 51.3 0.5 1.7 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Med28 PF11594.8 EMD65383.1 - 0.007 16.4 0.3 0.015 15.3 0.3 1.5 1 0 0 1 1 1 1 Mediator complex subunit 28 ZapB PF06005.12 EMD65383.1 - 0.043 14.3 1.2 0.12 12.9 1.2 1.7 1 0 0 1 1 1 0 Cell division protein ZapB MPS2 PF17060.5 EMD65383.1 - 0.13 11.6 4.4 0.22 10.8 4.4 1.3 1 0 0 1 1 1 0 Monopolar spindle protein 2 FAM76 PF16046.5 EMD65383.1 - 0.19 11.1 9.7 0.018 14.4 5.1 1.6 2 0 0 2 2 2 0 FAM76 protein CC2-LZ PF16516.5 EMD65383.1 - 0.54 10.6 4.0 1.2 9.6 4.0 1.5 1 0 0 1 1 1 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator End3 PF12761.7 EMD65383.1 - 0.95 9.6 6.6 2.3 8.3 6.6 1.7 1 1 0 1 1 1 0 Actin cytoskeleton-regulatory complex protein END3 G-gamma PF00631.22 EMD65384.1 - 7.6e-21 73.9 0.1 9e-21 73.7 0.1 1.1 1 0 0 1 1 1 1 GGL domain PCI PF01399.27 EMD65385.1 - 2.1e-08 34.6 2.3 1.5e-07 31.9 0.0 3.3 3 0 0 3 3 3 1 PCI domain PX PF00787.24 EMD65386.1 - 5.8e-27 93.9 0.0 6.7e-27 93.7 0.0 1.1 1 0 0 1 1 1 1 PX domain SSF PF00474.17 EMD65387.1 - 4.8e-06 25.7 28.6 6.3e-05 22.0 28.6 2.2 1 1 0 1 1 1 1 Sodium:solute symporter family Cu-oxidase_2 PF07731.14 EMD65389.1 - 5.8e-27 94.1 1.4 6e-24 84.3 2.0 2.5 2 0 0 2 2 2 2 Multicopper oxidase Cu-oxidase_3 PF07732.15 EMD65389.1 - 1.1e-18 67.3 0.0 2.8e-18 66.1 0.0 1.6 1 0 0 1 1 1 1 Multicopper oxidase Cu-oxidase PF00394.22 EMD65389.1 - 0.00019 21.6 0.0 0.0037 17.4 0.0 3.2 3 1 0 3 3 3 1 Multicopper oxidase CDP-OH_P_transf PF01066.21 EMD65390.1 - 1.2e-16 61.3 0.1 1.2e-16 61.3 0.1 3.4 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase DUF5313 PF17240.2 EMD65390.1 - 1.2 9.5 3.7 6.8 7.1 0.3 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5313) NIPSNAP PF07978.13 EMD65391.1 - 5.1e-40 135.8 0.2 2.3e-28 98.4 0.0 2.6 2 0 0 2 2 2 2 NIPSNAP RhoGAP PF00620.27 EMD65392.1 - 2.6e-49 166.9 0.0 4.9e-49 166.0 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain FCH PF00611.23 EMD65392.1 - 1.1e-10 41.6 0.6 3.7e-10 40.0 0.0 2.2 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain Serpin PF00079.20 EMD65392.1 - 0.22 10.8 1.9 13 5.0 0.0 2.3 2 0 0 2 2 2 0 Serpin (serine protease inhibitor) OmpH PF03938.14 EMD65392.1 - 5 7.5 15.1 11 6.3 14.7 1.7 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) Putative_PNPOx PF01243.20 EMD65393.1 - 6.1e-12 45.6 0.0 1.1e-11 44.7 0.0 1.4 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase HMG_box PF00505.19 EMD65394.1 - 2.2e-24 85.6 1.4 4e-24 84.8 0.6 1.8 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EMD65394.1 - 4.7e-09 36.7 0.4 1.6e-08 35.0 0.4 1.9 1 0 0 1 1 1 1 HMG-box domain Glyco_hydro_3_C PF01915.22 EMD65395.1 - 8.1e-47 159.8 0.1 2.3e-46 158.3 0.1 1.8 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 EMD65395.1 - 1.2e-41 143.1 0.0 1.8e-41 142.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 EMD65395.1 - 2.6e-24 85.1 0.1 4.9e-24 84.2 0.1 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain AMP-binding PF00501.28 EMD65397.1 - 4.3e-65 220.0 0.0 6.8e-65 219.3 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EMD65397.1 - 2.7e-12 47.5 0.1 5.2e-12 46.6 0.1 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain XPG_N PF00752.17 EMD65398.1 - 1.6e-35 121.6 0.1 4.5e-35 120.2 0.0 1.8 2 0 0 2 2 2 1 XPG N-terminal domain XPG_I PF00867.18 EMD65398.1 - 1.9e-25 89.0 0.0 6.2e-25 87.4 0.0 2.0 1 0 0 1 1 1 1 XPG I-region 5_3_exonuc PF01367.20 EMD65398.1 - 3e-05 24.5 2.2 8.6e-05 23.1 0.0 2.8 3 0 0 3 3 3 1 5'-3' exonuclease, C-terminal SAM fold Transposase_20 PF02371.16 EMD65398.1 - 0.0029 17.9 0.0 0.0072 16.6 0.0 1.6 1 0 0 1 1 1 1 Transposase IS116/IS110/IS902 family UIM PF02809.20 EMD65398.1 - 0.0055 16.5 2.4 0.0055 16.5 2.4 3.3 3 0 0 3 3 3 1 Ubiquitin interaction motif PUB_1 PF18486.1 EMD65398.1 - 0.021 14.7 0.0 0.09 12.7 0.0 2.1 1 0 0 1 1 1 0 PNGase/UBA- or UBX-containing domain HHH_5 PF14520.6 EMD65398.1 - 0.13 12.8 0.0 0.31 11.7 0.0 1.6 1 0 0 1 1 1 0 Helix-hairpin-helix domain HHH PF00633.23 EMD65398.1 - 0.16 11.9 0.1 0.47 10.4 0.1 1.8 1 0 0 1 1 1 0 Helix-hairpin-helix motif DUF3336 PF11815.8 EMD65399.1 - 9.7e-48 161.4 2.1 1.5e-47 160.8 2.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Patatin PF01734.22 EMD65399.1 - 1.9e-17 64.1 0.1 1.3e-16 61.4 0.0 2.3 2 0 0 2 2 2 1 Patatin-like phospholipase Peptidase_M22 PF00814.25 EMD65400.1 - 9.5e-49 166.5 0.1 1.3e-28 100.5 0.1 3.1 2 1 0 3 3 3 3 Glycoprotease family FGGY_C PF02782.16 EMD65400.1 - 0.067 12.9 0.2 0.37 10.5 0.1 2.0 2 0 0 2 2 2 0 FGGY family of carbohydrate kinases, C-terminal domain Adipokin_hormo PF06377.11 EMD65401.1 - 0.0029 17.9 0.2 3.4 8.1 0.0 3.2 3 0 0 3 3 3 2 Adipokinetic hormone Ribosomal_L30 PF00327.20 EMD65403.1 - 0.19 11.6 0.0 0.75 9.7 0.0 2.0 2 0 0 2 2 2 0 Ribosomal protein L30p/L7e CTP_transf_like PF01467.26 EMD65404.1 - 0.0002 21.6 0.1 0.00093 19.4 0.1 2.1 1 1 0 1 1 1 1 Cytidylyltransferase-like ATR13 PF16829.5 EMD65404.1 - 0.11 12.9 0.0 0.21 12.0 0.0 1.4 1 0 0 1 1 1 0 Avirulence protein ATR13, RxLR effector WD40 PF00400.32 EMD65405.1 - 1.3e-11 44.8 3.3 0.00038 21.2 0.0 4.8 4 0 0 4 4 4 3 WD domain, G-beta repeat Macoilin PF09726.9 EMD65405.1 - 0.86 8.1 6.2 1.1 7.7 6.2 1.1 1 0 0 1 1 1 0 Macoilin family Raffinose_syn PF05691.12 EMD65406.1 - 2.6e-50 171.0 4.9 3.3e-48 164.1 4.9 2.5 1 1 0 1 1 1 1 Raffinose synthase or seed imbibition protein Sip1 tRNA-synt_1b PF00579.25 EMD65407.1 - 1e-71 241.7 0.0 1.3e-71 241.3 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) TyrRSs_C PF16714.5 EMD65407.1 - 3e-27 94.8 0.0 1.8e-26 92.3 0.0 2.1 2 0 0 2 2 2 1 Tyrosyl-tRNA synthetase C-terminal domain S4 PF01479.25 EMD65407.1 - 0.16 11.7 0.1 0.42 10.4 0.1 1.7 1 0 0 1 1 1 0 S4 domain DUF997 PF06196.12 EMD65409.1 - 0.016 15.2 0.2 0.028 14.4 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF997) DUF4834 PF16118.5 EMD65409.1 - 0.08 13.9 0.2 0.32 12.0 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Castor1_N PF18700.1 EMD65411.1 - 0.15 11.9 0.1 1.6 8.6 0.0 2.1 2 0 0 2 2 2 0 Cytosolic arginine sensor for mTORC1 subunit 1 N-terminal domain NMT_C PF02799.15 EMD65412.1 - 3.7e-88 294.5 0.0 6.1e-88 293.8 0.0 1.4 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain NMT PF01233.19 EMD65412.1 - 1.2e-73 246.2 0.4 7.4e-73 243.7 0.0 2.0 2 0 0 2 2 2 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain Acetyltransf_9 PF13527.7 EMD65412.1 - 9.3e-07 29.0 0.1 5.4e-05 23.3 0.0 2.4 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EMD65412.1 - 0.0062 16.8 0.0 0.012 15.8 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family NTP_transf_9 PF04248.12 EMD65412.1 - 0.039 13.8 0.0 0.1 12.5 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF427) CEP19 PF14933.6 EMD65414.1 - 0.079 13.3 0.0 0.13 12.6 0.0 1.3 1 0 0 1 1 1 0 CEP19-like protein TPR_12 PF13424.6 EMD65414.1 - 0.083 13.2 0.1 0.98 9.8 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat Vps62 PF06101.11 EMD65415.1 - 4.6e-18 64.8 4.8 1.2e-17 63.5 4.8 1.6 1 1 0 1 1 1 1 Vacuolar protein sorting-associated protein 62 Catalase PF00199.19 EMD65416.1 - 1.3e-24 87.0 0.0 1.8e-24 86.6 0.0 1.0 1 0 0 1 1 1 1 Catalase MHB PF16525.5 EMD65416.1 - 0.056 13.7 0.0 0.13 12.5 0.0 1.6 1 0 0 1 1 1 0 Haemophore, haem-binding Dicty_CAR PF05462.11 EMD65419.1 - 2.9e-11 43.1 10.4 2.9e-11 43.1 10.4 1.9 2 0 0 2 2 2 1 Slime mold cyclic AMP receptor 7tm_2 PF00002.24 EMD65419.1 - 5.1e-05 22.7 11.4 5.1e-05 22.7 11.4 2.0 2 0 0 2 2 2 1 7 transmembrane receptor (Secretin family) Git3 PF11710.8 EMD65419.1 - 0.011 15.6 11.3 0.02 14.7 11.3 1.4 1 0 0 1 1 1 0 G protein-coupled glucose receptor regulating Gpa2 GPR_Gpa2_C PF11970.8 EMD65419.1 - 0.014 15.5 0.7 0.014 15.5 0.7 2.5 3 0 0 3 3 3 0 G protein-coupled glucose receptor regulating Gpa2 C-term CS PF04969.16 EMD65420.1 - 4.9e-16 59.5 0.0 4.9e-16 59.5 0.0 1.7 3 0 0 3 3 3 1 CS domain ANTH PF07651.16 EMD65421.1 - 9.8e-63 211.7 0.1 1.3e-62 211.3 0.1 1.2 1 0 0 1 1 1 1 ANTH domain ENTH PF01417.20 EMD65421.1 - 2.3e-06 27.7 0.0 4.2e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 ENTH domain preSET_CXC PF18264.1 EMD65422.1 - 9e-10 38.9 11.5 9e-10 38.9 11.5 3.6 3 1 1 4 4 4 1 CXC domain SET PF00856.28 EMD65422.1 - 9.6e-09 35.8 1.1 9.6e-09 35.8 1.1 3.3 3 2 0 3 3 3 1 SET domain DAHP_synth_2 PF01474.16 EMD65424.1 - 6.1e-206 684.1 0.0 6.9e-206 683.9 0.0 1.0 1 0 0 1 1 1 1 Class-II DAHP synthetase family Adhesin_P1 PF03257.13 EMD65424.1 - 0.13 12.8 0.1 0.35 11.4 0.1 1.7 1 0 0 1 1 1 0 Mycoplasma adhesin P1 Zn_clus PF00172.18 EMD65427.1 - 2.6e-07 30.7 7.9 6.4e-07 29.4 7.9 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FAM92 PF06730.11 EMD65427.1 - 0.13 11.6 0.0 0.3 10.5 0.0 1.5 2 0 0 2 2 2 0 FAM92 protein BTB PF00651.31 EMD65428.1 - 1.7e-12 47.6 0.0 4.5e-12 46.2 0.0 1.6 2 0 0 2 2 2 1 BTB/POZ domain Nucleoporin_FG PF13634.6 EMD65428.1 - 0.00077 20.3 6.8 0.0015 19.4 6.8 1.4 1 0 0 1 1 1 1 Nucleoporin FG repeat region DUF1989 PF09347.10 EMD65429.1 - 3e-29 101.8 0.0 1.6e-19 70.2 0.0 3.1 2 1 0 2 2 2 2 Domain of unknown function (DUF1989) CDC45 PF02724.14 EMD65429.1 - 2.2 6.5 22.1 0.36 9.1 13.4 2.1 2 0 0 2 2 2 0 CDC45-like protein FlgM PF04316.13 EMD65430.1 - 0.087 13.2 0.2 0.38 11.1 0.0 2.2 2 0 0 2 2 2 0 Anti-sigma-28 factor, FlgM PSDC PF12588.8 EMD65431.1 - 2.7e-63 212.1 0.0 4.6e-63 211.4 0.0 1.4 1 0 0 1 1 1 1 Phophatidylserine decarboxylase PS_Dcarbxylase PF02666.15 EMD65431.1 - 3.1e-35 121.6 0.0 8e-35 120.2 0.0 1.6 2 0 0 2 2 2 1 Phosphatidylserine decarboxylase Peptidase_M20 PF01546.28 EMD65432.1 - 1e-21 77.6 0.0 1.6e-21 77.0 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EMD65432.1 - 1.3e-13 50.8 0.1 3.1e-13 49.6 0.1 1.6 1 0 0 1 1 1 1 Peptidase dimerisation domain Complex1_LYR PF05347.15 EMD65434.1 - 5.9e-21 74.3 4.3 6.3e-21 74.2 3.5 1.5 2 0 0 2 2 2 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 EMD65434.1 - 6.4e-07 30.0 0.9 7.4e-07 29.8 0.9 1.1 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR_1 PF13232.6 EMD65434.1 - 0.0018 18.9 0.3 0.0021 18.6 0.3 1.2 1 0 0 1 1 1 1 Complex1_LYR-like PRP21_like_P PF12230.8 EMD65435.1 - 5.5e-50 170.2 3.8 2.1e-49 168.3 3.8 2.0 1 1 0 1 1 1 1 Pre-mRNA splicing factor PRP21 like protein Surp PF01805.20 EMD65435.1 - 2.3e-26 91.5 2.4 2.4e-14 53.0 0.7 2.4 2 0 0 2 2 2 2 Surp module zf_UBZ PF18439.1 EMD65435.1 - 0.00061 19.3 0.5 0.0018 17.9 0.5 1.7 1 0 0 1 1 1 1 Ubiquitin-Binding Zinc Finger PMT PF02366.18 EMD65436.1 - 4.8e-82 275.2 14.4 9.4e-82 274.3 14.4 1.5 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 EMD65436.1 - 9e-69 231.1 14.6 2e-68 229.9 14.6 1.6 1 0 0 1 1 1 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 EMD65436.1 - 1.9e-48 164.8 0.0 3.9e-48 163.8 0.0 1.5 1 0 0 1 1 1 1 MIR domain HTH_Tnp_Tc5 PF03221.16 EMD65439.1 - 4.5e-09 36.2 0.1 9.1e-09 35.2 0.1 1.6 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EMD65439.1 - 0.0018 18.0 0.1 0.0028 17.4 0.1 1.3 1 0 0 1 1 1 1 helix-turn-helix, Psq domain Ribosomal_S13_N PF08069.12 EMD65439.1 - 0.021 14.9 0.1 0.064 13.3 0.0 1.8 2 0 0 2 2 2 0 Ribosomal S13/S15 N-terminal domain Drf_GBD PF06371.13 EMD65439.1 - 0.021 14.4 0.0 0.026 14.1 0.0 1.2 1 0 0 1 1 1 0 Diaphanous GTPase-binding Domain Cdc6_C PF09079.11 EMD65439.1 - 0.07 13.1 0.2 9.1 6.3 0.0 2.6 3 0 0 3 3 3 0 CDC6, C terminal winged helix domain HTH_24 PF13412.6 EMD65439.1 - 0.11 12.1 0.1 0.77 9.4 0.0 2.2 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding Aldolase_II PF00596.21 EMD65440.1 - 1.1e-38 133.0 0.6 2.4e-38 131.9 0.6 1.5 1 1 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain Mpt_N PF09176.11 EMD65440.1 - 0.16 12.1 0.0 0.35 11.0 0.0 1.6 1 0 0 1 1 1 0 Methylene-tetrahydromethanopterin dehydrogenase, N-terminal RhgB_N PF09284.10 EMD65441.1 - 2e-104 348.6 2.1 2.9e-104 348.1 2.1 1.2 1 0 0 1 1 1 1 Rhamnogalacturonan lyase B, N-terminal CBM-like PF14683.6 EMD65441.1 - 3.9e-37 127.7 0.0 9.8e-37 126.4 0.0 1.7 1 0 0 1 1 1 1 Polysaccharide lyase family 4, domain III fn3_3 PF14686.6 EMD65441.1 - 4.5e-20 71.2 6.5 4.5e-20 71.2 6.5 2.6 2 0 0 2 2 2 1 Polysaccharide lyase family 4, domain II CarboxypepD_reg PF13620.6 EMD65441.1 - 0.0028 17.9 2.9 0.0028 17.9 2.9 2.7 3 0 0 3 3 3 1 Carboxypeptidase regulatory-like domain HTH_Tnp_Tc3_2 PF01498.18 EMD65442.1 - 7e-17 61.5 1.8 1.1e-16 60.8 0.9 1.8 2 0 0 2 2 2 1 Transposase HTH_32 PF13565.6 EMD65442.1 - 8.5e-08 32.7 1.6 1e-07 32.4 0.1 1.8 2 0 0 2 2 2 1 Homeodomain-like domain Sigma70_r4 PF04545.16 EMD65442.1 - 1.3e-05 24.6 0.2 0.11 12.0 0.1 2.9 2 1 0 2 2 2 2 Sigma-70, region 4 DDE_Tnp_ISAZ013 PF07592.11 EMD65442.1 - 4.6e-05 22.5 0.1 7.8e-05 21.8 0.1 1.3 1 1 0 1 1 1 1 Rhodopirellula transposase DDE domain HTH_33 PF13592.6 EMD65442.1 - 0.00029 20.4 0.0 0.00074 19.1 0.0 1.6 2 0 0 2 2 2 1 Winged helix-turn helix Sigma70_r4_2 PF08281.12 EMD65442.1 - 0.00077 19.1 0.4 0.048 13.3 0.1 2.2 2 0 0 2 2 2 1 Sigma-70, region 4 HTH_23 PF13384.6 EMD65442.1 - 0.0044 16.8 0.0 0.96 9.3 0.0 2.5 2 0 0 2 2 2 1 Homeodomain-like domain HTH_21 PF13276.6 EMD65442.1 - 0.012 15.7 0.0 0.023 14.8 0.0 1.5 1 0 0 1 1 1 0 HTH-like domain UB2H PF14814.6 EMD65442.1 - 0.022 14.8 0.0 0.051 13.6 0.0 1.6 1 0 0 1 1 1 0 Bifunctional transglycosylase second domain CENP-B_N PF04218.13 EMD65442.1 - 0.05 13.3 0.0 3.2 7.5 0.0 2.5 2 0 0 2 2 2 0 CENP-B N-terminal DNA-binding domain UPF0183 PF03676.14 EMD65445.1 - 7.6e-48 163.7 0.0 3.5e-32 112.2 0.0 3.2 3 0 0 3 3 3 3 Uncharacterised protein family (UPF0183) tRNA-synt_1 PF00133.22 EMD65446.1 - 2.2e-157 525.0 0.0 2.9e-157 524.6 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 EMD65446.1 - 6.8e-21 74.5 0.1 3.6e-13 49.0 0.0 3.6 3 0 0 3 3 3 3 tRNA synthetases class I (M) Anticodon_1 PF08264.13 EMD65446.1 - 2.7e-18 66.4 0.0 5.1e-18 65.5 0.0 1.5 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA zf-FPG_IleRS PF06827.14 EMD65446.1 - 0.0018 18.1 6.0 0.0044 16.9 6.0 1.7 1 0 0 1 1 1 1 Zinc finger found in FPG and IleRS tRNA-synt_1e PF01406.19 EMD65446.1 - 0.0068 15.8 0.0 0.91 8.8 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain DUF5066 PF16728.5 EMD65446.1 - 0.12 11.7 0.0 0.26 10.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5066) PDEase_I PF00233.19 EMD65447.1 - 2.2e-68 230.5 0.0 3.2e-68 230.0 0.0 1.2 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase DUF1688 PF07958.11 EMD65449.1 - 1e-172 574.6 0.0 1.2e-172 574.4 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1688) Q_salvage PF10343.9 EMD65449.1 - 1.1e-06 28.4 0.0 0.02 14.5 0.0 2.1 2 0 0 2 2 2 2 Potential Queuosine, Q, salvage protein family Shisa PF13908.6 EMD65450.1 - 0.0016 18.7 0.0 0.0016 18.7 0.0 1.9 2 1 1 3 3 3 1 Wnt and FGF inhibitory regulator stn_TNFRSF12A PF12191.8 EMD65450.1 - 0.024 14.9 0.0 0.069 13.4 0.0 1.8 1 0 0 1 1 1 0 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain Vpu PF00558.19 EMD65450.1 - 0.096 12.5 0.1 0.17 11.6 0.1 1.3 1 0 0 1 1 1 0 Vpu protein SKG6 PF08693.10 EMD65451.1 - 1.3e-05 24.5 4.5 2.2e-05 23.8 4.5 1.4 1 0 0 1 1 1 1 Transmembrane alpha-helix domain SARAF PF06682.12 EMD65451.1 - 0.0011 18.8 0.5 0.0015 18.3 0.5 1.2 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis EphA2_TM PF14575.6 EMD65451.1 - 0.0013 19.5 0.0 0.0026 18.6 0.0 1.5 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain Phage_Coat_B PF05356.11 EMD65451.1 - 0.0034 17.2 0.0 0.0092 15.9 0.0 1.8 2 0 0 2 2 2 1 Phage Coat protein B Beta-APP PF03494.13 EMD65451.1 - 0.0035 17.2 0.8 0.0035 17.2 0.8 1.8 2 0 0 2 2 1 1 Beta-amyloid peptide (beta-APP) TMEM51 PF15345.6 EMD65451.1 - 0.0038 17.1 0.1 0.0054 16.6 0.1 1.2 1 0 0 1 1 1 1 Transmembrane protein 51 RCR PF12273.8 EMD65451.1 - 0.005 17.5 1.2 0.0059 17.2 0.1 1.7 2 0 0 2 2 1 1 Chitin synthesis regulation, resistance to Congo red Podoplanin PF05808.11 EMD65451.1 - 0.0072 16.4 0.8 0.022 14.8 0.1 2.0 2 0 0 2 2 2 1 Podoplanin RIFIN PF02009.16 EMD65451.1 - 0.012 15.6 0.0 0.017 15.1 0.0 1.2 1 0 0 1 1 1 0 Rifin Adeno_E3_CR2 PF02439.15 EMD65451.1 - 0.016 14.9 1.0 0.029 14.1 1.0 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Herpes_gE PF02480.16 EMD65451.1 - 0.022 13.5 0.0 0.03 13.1 0.0 1.2 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E DUF3827 PF12877.7 EMD65451.1 - 0.03 12.7 0.0 0.041 12.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) DUF2207 PF09972.9 EMD65451.1 - 0.037 12.8 0.0 0.047 12.4 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Orf78 PF06024.12 EMD65451.1 - 0.038 14.3 0.0 0.079 13.3 0.0 1.4 1 0 0 1 1 1 0 Orf78 (ac78) TMEM154 PF15102.6 EMD65451.1 - 0.043 13.7 0.1 0.14 12.0 0.0 1.8 1 1 1 2 2 2 0 TMEM154 protein family Insulin_TMD PF17870.1 EMD65451.1 - 0.055 13.5 0.6 0.09 12.9 0.6 1.3 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment DUF5385 PF17359.2 EMD65451.1 - 0.069 12.7 0.2 0.11 12.0 0.2 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5385) PDGLE PF13190.6 EMD65451.1 - 0.088 12.7 0.0 0.16 11.8 0.0 1.6 1 0 0 1 1 1 0 PDGLE domain Syndecan PF01034.20 EMD65451.1 - 0.15 12.0 1.5 0.31 11.0 1.5 1.4 1 0 0 1 1 1 0 Syndecan domain SOG2 PF10428.9 EMD65451.1 - 2.7 7.1 6.0 3.3 6.8 6.0 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein DUF3433 PF11915.8 EMD65453.1 - 4.6e-34 116.7 19.7 6.1e-23 81.1 5.0 3.9 5 0 0 5 5 5 2 Protein of unknown function (DUF3433) TM231 PF10149.9 EMD65453.1 - 0.024 14.0 0.0 0.057 12.7 0.0 1.5 1 0 0 1 1 1 0 Transmembrane protein 231 TP_methylase PF00590.20 EMD65454.1 - 3.6e-50 170.9 0.2 7.1e-50 169.9 0.2 1.5 2 0 0 2 2 2 1 Tetrapyrrole (Corrin/Porphyrin) Methylases Sirohm_synth_M PF14824.6 EMD65454.1 - 1.5e-11 43.5 0.2 4.4e-11 42.0 0.2 1.9 1 0 0 1 1 1 1 Sirohaem biosynthesis protein central Sirohm_synth_C PF14823.6 EMD65454.1 - 4.2e-11 42.3 0.1 2.2e-07 30.4 0.0 2.3 2 0 0 2 2 2 2 Sirohaem biosynthesis protein C-terminal NAD_binding_7 PF13241.6 EMD65454.1 - 5e-11 43.0 0.0 8.9e-11 42.2 0.0 1.4 1 0 0 1 1 1 1 Putative NAD(P)-binding Rogdi_lz PF10259.9 EMD65455.1 - 1.5e-86 290.2 0.0 1.7e-86 290.0 0.0 1.0 1 0 0 1 1 1 1 Rogdi leucine zipper containing protein SUR7 PF06687.12 EMD65456.1 - 2e-36 125.6 4.2 2.4e-36 125.4 4.2 1.0 1 0 0 1 1 1 1 SUR7/PalI family DUF373 PF04123.13 EMD65456.1 - 0.00012 21.7 0.3 0.00018 21.1 0.3 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF373) Clc-like PF07062.12 EMD65456.1 - 0.01 15.3 1.6 0.01 15.3 1.6 1.5 2 0 0 2 2 2 0 Clc-like Amastin PF07344.11 EMD65456.1 - 0.63 9.9 8.6 0.99 9.2 6.3 2.0 2 0 0 2 2 2 0 Amastin surface glycoprotein Claudin_2 PF13903.6 EMD65456.1 - 1.4 8.6 10.2 0.88 9.3 5.7 2.5 1 1 1 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction SAICAR_synt PF01259.18 EMD65457.1 - 6.5e-99 330.6 0.0 7.6e-99 330.4 0.0 1.0 1 0 0 1 1 1 1 SAICAR synthetase Atg29_N PF18388.1 EMD65458.1 - 8.6e-24 83.1 1.2 3e-23 81.4 1.3 1.9 2 0 0 2 2 2 1 Atg29 N-terminal domain Med12 PF09497.10 EMD65461.1 - 1.1e-24 86.5 0.2 2.5e-24 85.3 0.2 1.7 1 0 0 1 1 1 1 Transcription mediator complex subunit Med12 Nucleo_P87 PF07267.11 EMD65461.1 - 0.14 11.0 5.6 0.2 10.5 5.6 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 SRR1 PF07985.12 EMD65461.1 - 0.19 11.8 1.5 0.87 9.7 0.0 2.9 4 0 0 4 4 4 0 SRR1 Suf PF05843.14 EMD65461.1 - 3.4 7.6 11.2 6.2 6.7 11.2 1.4 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) UPF0139 PF03669.13 EMD65462.1 - 9.6e-08 31.8 0.1 1.2e-07 31.5 0.1 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0139) CD20 PF04103.15 EMD65462.1 - 0.083 13.0 1.4 0.11 12.6 1.4 1.2 1 0 0 1 1 1 0 CD20-like family SUI1 PF01253.22 EMD65463.1 - 6.4e-28 97.1 3.8 9.2e-28 96.6 3.8 1.2 1 0 0 1 1 1 1 Translation initiation factor SUI1 GlcNAc-1_reg PF18440.1 EMD65463.1 - 0.11 12.7 0.3 0.22 11.8 0.2 1.5 2 0 0 2 2 2 0 Putative GlcNAc-1 phosphotransferase regulatory domain Tim44 PF04280.15 EMD65464.1 - 6.4e-05 23.1 0.0 0.013 15.6 0.0 2.4 2 0 0 2 2 2 2 Tim44-like domain Band_3_cyto PF07565.13 EMD65464.1 - 0.14 11.9 1.1 0.41 10.4 0.1 1.9 2 0 0 2 2 2 0 Band 3 cytoplasmic domain Mito_carr PF00153.27 EMD65465.1 - 1.3e-72 239.8 2.8 3.4e-23 81.4 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein CIA30 PF08547.12 EMD65466.1 - 9.5e-44 149.2 0.0 1.2e-43 148.9 0.0 1.1 1 0 0 1 1 1 1 Complex I intermediate-associated protein 30 (CIA30) ANAPC5 PF12862.7 EMD65467.1 - 2.4e-30 104.5 10.1 3.8e-30 103.8 5.1 3.5 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 5 RPN7 PF10602.9 EMD65467.1 - 9e-05 22.2 0.1 0.0006 19.6 0.2 2.2 2 0 0 2 2 2 1 26S proteasome subunit RPN7 TPR_19 PF14559.6 EMD65467.1 - 0.0019 18.7 3.2 1.7 9.2 0.5 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 EMD65467.1 - 0.0021 18.3 8.1 1 9.7 0.0 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat COX6A PF02046.15 EMD65468.1 - 9.3e-46 154.9 4.5 1.1e-45 154.6 4.5 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIa Exo_endo_phos PF03372.23 EMD65469.1 - 5.9e-10 39.1 0.0 9.7e-10 38.4 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family zf-GRF PF06839.12 EMD65469.1 - 1.5e-05 25.0 6.7 4.4e-05 23.5 6.7 1.8 1 1 0 1 1 1 1 GRF zinc finger Nyv1_N PF09426.10 EMD65469.1 - 0.087 12.8 0.0 0.15 12.1 0.0 1.3 1 0 0 1 1 1 0 Vacuolar R-SNARE Nyv1 N terminal Exo_endo_phos_2 PF14529.6 EMD65469.1 - 0.13 12.1 0.0 20 5.1 0.0 2.7 2 0 0 2 2 2 0 Endonuclease-reverse transcriptase Myb_DNA-binding PF00249.31 EMD65470.1 - 2.6e-07 30.7 0.5 1.5e-06 28.3 0.1 2.1 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EMD65470.1 - 3.7e-05 23.9 0.4 0.00055 20.1 0.0 2.4 1 1 1 2 2 2 1 Myb-like DNA-binding domain PAT1 PF09770.9 EMD65470.1 - 2.6 6.2 20.9 2.6 6.2 20.9 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SIR2 PF02146.17 EMD65471.1 - 1e-28 100.4 0.0 1.7e-28 99.7 0.0 1.4 1 0 0 1 1 1 1 Sir2 family zf-C3HC4_3 PF13920.6 EMD65472.1 - 0.24 11.3 7.4 0.39 10.6 7.4 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.24 EMD65472.1 - 2.4 8.4 7.5 3.8 7.7 7.5 1.2 1 0 0 1 1 1 0 B-box zinc finger adh_short PF00106.25 EMD65474.1 - 1.2e-36 126.1 0.1 1.6e-36 125.6 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD65474.1 - 2.4e-30 105.8 0.1 3.5e-30 105.3 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD65474.1 - 0.003 17.5 1.1 0.01 15.8 0.4 2.1 2 1 0 2 2 2 1 KR domain Epimerase PF01370.21 EMD65474.1 - 0.0047 16.4 0.0 0.0072 15.8 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family DFP PF04127.15 EMD65474.1 - 0.0094 15.8 0.0 0.016 15.0 0.0 1.3 1 0 0 1 1 1 1 DNA / pantothenate metabolism flavoprotein Arylesterase PF01731.20 EMD65475.1 - 0.0012 19.0 0.0 0.015 15.5 0.0 2.2 2 0 0 2 2 2 1 Arylesterase FAD_binding_4 PF01565.23 EMD65476.1 - 5.3e-21 74.8 1.1 8.9e-21 74.1 1.1 1.4 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EMD65476.1 - 3.3e-13 49.5 0.3 1.4e-12 47.5 0.2 2.1 2 0 0 2 2 2 1 Berberine and berberine like Fungal_trans PF04082.18 EMD65478.1 - 1.6e-05 24.1 0.0 8.8e-05 21.7 0.0 2.0 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD65478.1 - 2e-05 24.6 10.8 3.1e-05 24.0 10.8 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain GCD14 PF08704.10 EMD65479.1 - 2.1e-11 44.0 0.0 5e-09 36.2 0.0 2.2 2 0 0 2 2 2 2 tRNA methyltransferase complex GCD14 subunit Methyltransf_31 PF13847.6 EMD65479.1 - 6.2e-05 22.8 0.0 0.0046 16.8 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain GCD14_N PF14801.6 EMD65479.1 - 0.0018 18.1 0.5 0.0032 17.3 0.5 1.4 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit N-term Methyltransf_25 PF13649.6 EMD65479.1 - 0.0026 18.5 0.0 1.4 9.7 0.0 2.5 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_24 PF13578.6 EMD65479.1 - 0.14 13.2 0.0 0.5 11.4 0.0 2.0 1 1 0 1 1 1 0 Methyltransferase domain Metallophos PF00149.28 EMD65480.1 - 2.1e-18 67.5 3.2 4.6e-18 66.5 3.2 1.6 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EMD65480.1 - 4.7e-06 26.9 0.0 4.5e-05 23.7 0.0 2.1 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Glyoxal_oxid_N PF07250.11 EMD65481.1 - 5.3e-38 130.6 0.1 4.3e-37 127.6 0.0 2.5 2 1 0 2 2 2 1 Glyoxal oxidase N-terminus DUF1929 PF09118.11 EMD65481.1 - 4.5e-25 87.8 1.1 1.1e-24 86.6 1.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1929) Chitin_bind_1 PF00187.19 EMD65481.1 - 2.6e-23 82.2 90.2 2.8e-10 40.5 19.4 3.9 4 0 0 4 4 4 3 Chitin recognition protein DUF35_N PF12172.8 EMD65482.1 - 1.6 8.7 4.7 0.64 9.9 1.0 2.3 2 0 0 2 2 2 0 Rubredoxin-like zinc ribbon domain (DUF35_N) MFS_1 PF07690.16 EMD65483.1 - 1.4e-31 109.7 22.8 1.4e-31 109.7 22.8 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily DFP PF04127.15 EMD65484.1 - 3.4e-14 53.1 0.0 3.7e-06 26.9 0.0 3.2 2 1 0 2 2 2 2 DNA / pantothenate metabolism flavoprotein HET PF06985.11 EMD65485.1 - 7.3e-23 81.5 0.5 1.4e-22 80.6 0.1 1.7 2 0 0 2 2 2 1 Heterokaryon incompatibility protein (HET) DUF5417 PF17438.2 EMD65485.1 - 0.1 12.9 0.1 0.82 10.0 0.0 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5417) Fungal_trans PF04082.18 EMD65486.1 - 9.3e-13 47.8 0.2 1.8e-12 46.8 0.2 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD65486.1 - 6e-08 32.7 12.3 1.5e-07 31.4 12.3 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Mitochondr_Som1 PF11093.8 EMD65487.1 - 0.00011 22.2 0.1 0.00036 20.5 0.2 2.0 1 1 0 1 1 1 1 Mitochondrial export protein Som1 eIF3_p135 PF12807.7 EMD65487.1 - 0.34 10.9 1.9 0.85 9.6 0.2 2.1 2 0 0 2 2 2 0 Translation initiation factor eIF3 subunit 135 ChlI PF13541.6 EMD65490.1 - 0.15 11.9 0.0 0.28 11.1 0.0 1.3 1 0 0 1 1 1 0 Subunit ChlI of Mg-chelatase Fungal_trans_2 PF11951.8 EMD65493.1 - 2.2e-11 43.2 0.6 4.8e-06 25.6 0.1 2.3 2 0 0 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD65493.1 - 2.7e-07 30.6 11.3 5.1e-07 29.7 11.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FAS_I_H PF18314.1 EMD65493.1 - 0.13 11.9 0.0 0.23 11.0 0.0 1.3 1 0 0 1 1 1 0 Fatty acid synthase type I helical domain SSrecog PF03531.14 EMD65494.1 - 1.3e-29 101.9 0.0 1.2e-28 98.8 0.0 2.6 2 0 0 2 2 2 1 Structure-specific recognition protein (SSRP1) POB3_N PF17292.2 EMD65494.1 - 4.8e-29 100.6 0.2 9.6e-28 96.5 0.1 2.4 2 0 0 2 2 2 1 POB3-like N-terminal PH domain Rtt106 PF08512.12 EMD65494.1 - 6.9e-27 93.7 0.0 3.1e-26 91.6 0.0 2.1 2 0 0 2 2 2 1 Histone chaperone Rttp106-like DUF4974 PF16344.5 EMD65494.1 - 0.13 12.3 0.8 5.9 7.0 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4974) CDC45 PF02724.14 EMD65494.1 - 4 5.6 8.3 6.3 5.0 8.3 1.3 1 0 0 1 1 1 0 CDC45-like protein YL1 PF05764.13 EMD65494.1 - 6.1 6.9 21.7 16 5.6 21.7 1.8 1 1 0 1 1 1 0 YL1 nuclear protein HET PF06985.11 EMD65495.1 - 4.7e-15 56.2 0.0 1.4e-14 54.7 0.0 1.8 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) DNA_pol_B PF00136.21 EMD65497.1 - 2.2e-106 356.3 0.0 3.5e-106 355.6 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 EMD65497.1 - 4.2e-22 78.7 0.3 6.3e-13 48.6 0.1 2.5 2 0 0 2 2 2 2 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.6 EMD65497.1 - 4.9e-18 65.3 3.5 4.9e-18 65.3 3.5 2.1 2 0 0 2 2 2 1 C4-type zinc-finger of DNA polymerase delta DNA_pol_B_2 PF03175.13 EMD65497.1 - 0.17 10.7 0.2 0.29 9.9 0.2 1.2 1 0 0 1 1 1 0 DNA polymerase type B, organellar and viral Slu7 PF11708.8 EMD65498.1 - 2.3e-78 263.7 21.6 2.3e-78 263.7 21.6 3.0 3 1 0 3 3 3 1 Pre-mRNA splicing Prp18-interacting factor zf-CCHC_4 PF14392.6 EMD65498.1 - 0.043 13.6 0.5 0.08 12.7 0.5 1.4 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC PF00098.23 EMD65498.1 - 0.59 10.3 3.1 1.1 9.4 3.1 1.4 1 0 0 1 1 1 0 Zinc knuckle ANTH PF07651.16 EMD65499.1 - 7.4e-81 271.2 0.0 7.4e-81 271.2 0.0 3.1 3 1 0 3 3 3 1 ANTH domain I_LWEQ PF01608.17 EMD65499.1 - 6.5e-55 185.6 8.5 6.5e-55 185.6 8.5 6.3 3 2 1 5 5 5 3 I/LWEQ domain T2SSF PF00482.23 EMD65499.1 - 1.1 9.2 4.2 2.1 8.3 1.3 3.0 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein F MFS_1 PF07690.16 EMD65500.1 - 1.7e-42 145.6 30.6 1.7e-42 145.6 30.6 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 EMD65500.1 - 6.1e-07 28.2 5.8 1.1e-06 27.5 5.8 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) PRIMA1 PF16101.5 EMD65500.1 - 8.2 6.5 8.9 0.64 10.1 1.6 2.2 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 AhpC-TSA PF00578.21 EMD65501.1 - 6.6e-31 106.8 0.0 8.8e-31 106.4 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family 1-cysPrx_C PF10417.9 EMD65501.1 - 2.9e-12 46.2 0.1 5.5e-12 45.3 0.1 1.5 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin Redoxin PF08534.10 EMD65501.1 - 5.2e-12 45.7 0.0 7.4e-12 45.2 0.0 1.3 1 0 0 1 1 1 1 Redoxin Kelch_4 PF13418.6 EMD65502.1 - 2e-16 59.7 0.2 2e-06 27.7 0.0 4.9 4 1 0 4 4 4 2 Galactose oxidase, central domain Kelch_3 PF13415.6 EMD65502.1 - 1.5e-12 47.5 11.3 2.7e-11 43.5 0.0 5.0 6 0 0 6 6 6 1 Galactose oxidase, central domain Kelch_1 PF01344.25 EMD65502.1 - 3.9e-12 45.5 0.2 9.9e-05 21.8 0.0 4.3 3 1 0 3 3 3 3 Kelch motif Kelch_5 PF13854.6 EMD65502.1 - 1.6e-11 43.9 4.7 0.00048 20.1 0.5 4.5 4 1 0 4 4 4 2 Kelch motif Kelch_6 PF13964.6 EMD65502.1 - 2e-08 34.2 2.0 0.05 13.9 0.0 5.4 4 1 1 5 5 5 2 Kelch motif Kelch_2 PF07646.15 EMD65502.1 - 1.6e-07 31.0 0.8 0.00016 21.5 0.0 4.4 4 0 0 4 4 4 1 Kelch motif BTB PF00651.31 EMD65502.1 - 0.0099 16.1 0.0 0.14 12.4 0.0 2.2 2 0 0 2 2 2 1 BTB/POZ domain SRP-alpha_N PF04086.13 EMD65502.1 - 0.19 11.6 0.0 0.46 10.4 0.0 1.6 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Claudin_2 PF13903.6 EMD65503.1 - 0.024 14.4 0.1 0.031 14.0 0.1 1.1 1 0 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction adh_short_C2 PF13561.6 EMD65504.1 - 1.1e-57 195.3 0.1 1.2e-57 195.1 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EMD65504.1 - 8.7e-48 162.4 0.2 1e-47 162.1 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EMD65504.1 - 3.5e-16 59.6 0.2 4.7e-16 59.2 0.2 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EMD65504.1 - 0.00079 19.0 0.0 0.0011 18.5 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF3277 PF11681.8 EMD65504.1 - 0.011 15.6 0.1 0.017 15.0 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3277) Pyr_redox_2 PF07992.14 EMD65504.1 - 0.013 14.8 0.1 0.033 13.4 0.0 1.6 1 1 1 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase GDP_Man_Dehyd PF16363.5 EMD65504.1 - 0.026 13.9 0.0 0.12 11.8 0.0 2.0 2 1 0 2 2 2 0 GDP-mannose 4,6 dehydratase Alk_phosphatase PF00245.20 EMD65504.1 - 0.043 12.8 0.0 0.051 12.5 0.0 1.1 1 0 0 1 1 1 0 Alkaline phosphatase Lipoprotein_1 PF00820.19 EMD65504.1 - 0.074 12.1 0.0 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 Borrelia lipoprotein ZZ PF00569.17 EMD65505.1 - 1.3e-13 50.6 8.0 2.5e-13 49.6 8.0 1.5 1 0 0 1 1 1 1 Zinc finger, ZZ type EF-hand_1 PF00036.32 EMD65505.1 - 1.6e-10 39.8 4.1 0.00012 21.4 0.2 3.6 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 EMD65505.1 - 2.2e-09 36.5 1.9 0.0041 16.9 0.1 3.7 4 0 0 4 4 4 2 EF-hand domain EF-hand_7 PF13499.6 EMD65505.1 - 2.5e-08 34.3 0.1 0.0018 18.7 0.1 4.1 3 1 0 3 3 3 2 EF-hand domain pair EF-hand_8 PF13833.6 EMD65505.1 - 0.00066 19.5 5.0 1.2 9.0 0.2 4.8 6 0 0 6 6 6 2 EF-hand domain pair EF-hand_5 PF13202.6 EMD65505.1 - 0.0046 16.4 3.3 1.4 8.5 0.0 2.9 3 0 0 3 3 3 2 EF hand FA_desaturase PF00487.24 EMD65506.1 - 3.6e-13 50.0 22.2 3.6e-13 50.0 22.2 1.5 1 1 1 2 2 2 1 Fatty acid desaturase DUF1378 PF07125.11 EMD65506.1 - 0.58 10.4 2.3 1.3 9.2 2.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1378) Lipase_3 PF01764.25 EMD65507.1 - 2.8e-34 118.0 0.0 5.2e-34 117.1 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) Hydrolase_4 PF12146.8 EMD65507.1 - 7.2e-05 22.2 0.0 0.00011 21.5 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Lipase3_N PF03893.16 EMD65507.1 - 0.00025 21.0 0.0 0.00048 20.1 0.0 1.5 1 0 0 1 1 1 1 Lipase 3 N-terminal region DUF2974 PF11187.8 EMD65507.1 - 0.001 18.7 0.0 0.0031 17.1 0.0 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF2974) Abhydrolase_6 PF12697.7 EMD65507.1 - 0.0019 18.9 0.1 0.0024 18.5 0.1 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_8 PF06259.12 EMD65507.1 - 0.0019 17.8 0.1 0.0027 17.3 0.1 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase Thioesterase PF00975.20 EMD65507.1 - 0.013 15.6 0.1 0.025 14.7 0.1 1.3 1 0 0 1 1 1 0 Thioesterase domain Esterase PF00756.20 EMD65507.1 - 0.065 12.9 0.0 0.089 12.4 0.0 1.2 1 0 0 1 1 1 0 Putative esterase DUF676 PF05057.14 EMD65507.1 - 0.077 12.5 0.0 0.11 12.0 0.0 1.2 1 0 0 1 1 1 0 Putative serine esterase (DUF676) PGAP1 PF07819.13 EMD65507.1 - 0.14 11.9 0.0 0.3 10.8 0.0 1.5 1 0 0 1 1 1 0 PGAP1-like protein Mur_ligase PF01225.25 EMD65509.1 - 0.19 12.1 0.0 4.7 7.6 0.0 2.4 1 1 1 2 2 2 0 Mur ligase family, catalytic domain Gram_pos_anchor PF00746.21 EMD65509.1 - 0.82 9.7 3.3 2 8.4 3.3 1.7 1 0 0 1 1 1 0 LPXTG cell wall anchor motif Glyco_hydro_61 PF03443.14 EMD65510.1 - 0.15 12.0 2.7 0.22 11.4 0.1 2.5 2 1 0 2 2 2 0 Glycosyl hydrolase family 61 CBM_19 PF03427.13 EMD65510.1 - 3.3 7.8 20.3 0.72 9.9 8.0 3.4 3 0 0 3 3 3 0 Carbohydrate binding domain (family 19) SKG6 PF08693.10 EMD65511.1 - 0.0046 16.3 0.0 0.0086 15.5 0.0 1.4 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Hydrolase_4 PF12146.8 EMD65513.1 - 1.8e-06 27.4 0.0 1.3e-05 24.6 0.0 2.3 1 1 1 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EMD65513.1 - 2e-05 25.3 0.2 3.5e-05 24.5 0.2 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EMD65513.1 - 0.016 14.9 0.0 0.025 14.2 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold GTP_EFTU PF00009.27 EMD65514.1 - 1.2e-58 197.9 0.3 2.8e-58 196.7 0.3 1.6 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 EMD65514.1 - 2.8e-34 117.5 0.1 5.9e-34 116.4 0.1 1.6 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_II PF14492.6 EMD65514.1 - 2.2e-33 114.2 0.0 5.1e-33 113.0 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 EMD65514.1 - 1.8e-23 82.4 0.0 7.4e-23 80.4 0.0 2.1 2 0 0 2 2 2 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 EMD65514.1 - 1.3e-14 54.3 0.0 2.8e-14 53.2 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RF3_C PF16658.5 EMD65514.1 - 4.1e-07 29.9 0.1 2.1e-06 27.6 0.0 2.2 2 0 0 2 2 2 1 Class II release factor RF3, C-terminal domain DUF442 PF04273.13 EMD65514.1 - 0.064 13.3 0.0 0.67 10.1 0.0 2.4 2 0 0 2 2 2 0 Putative phosphatase (DUF442) RdRP PF05183.12 EMD65516.1 - 2.8e-181 604.1 0.0 3.5e-181 603.8 0.0 1.1 1 0 0 1 1 1 1 RNA dependent RNA polymerase hnRNP_Q_AcD PF18360.1 EMD65516.1 - 0.14 12.2 0.2 0.85 9.6 0.0 2.4 3 0 0 3 3 3 0 Heterogeneous nuclear ribonucleoprotein Q acidic domain DUF3176 PF11374.8 EMD65518.1 - 5.3e-32 110.2 0.2 5.3e-32 110.2 0.2 1.9 1 1 1 2 2 2 1 Protein of unknown function (DUF3176) Thia_YuaJ PF09515.10 EMD65518.1 - 0.028 14.4 0.2 0.043 13.8 0.2 1.2 1 0 0 1 1 1 0 Thiamine transporter protein (Thia_YuaJ) ELP6 PF09807.9 EMD65519.1 - 1.2e-07 31.4 0.0 0.00028 20.4 0.0 2.1 2 0 0 2 2 2 2 Elongation complex protein 6 ATPase PF06745.13 EMD65519.1 - 0.14 11.4 0.0 0.25 10.7 0.0 1.3 1 0 0 1 1 1 0 KaiC AltA1 PF16541.5 EMD65521.1 - 1.1e-13 52.0 0.0 1.4e-13 51.7 0.0 1.1 1 0 0 1 1 1 1 Alternaria alternata allergen 1 Rdx PF10262.9 EMD65523.1 - 1.3e-31 108.5 0.0 2e-31 108.0 0.0 1.3 1 0 0 1 1 1 1 Rdx family SQS_PSY PF00494.19 EMD65524.1 - 1.7e-38 132.6 0.0 2.8e-38 131.9 0.0 1.3 1 0 0 1 1 1 1 Squalene/phytoene synthase PRIMA1 PF16101.5 EMD65524.1 - 0.063 13.3 0.0 0.14 12.2 0.0 1.5 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 IF4E PF01652.18 EMD65525.1 - 3.6e-54 182.9 0.2 4.5e-54 182.5 0.2 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E DnaJ-X PF14308.6 EMD65526.1 - 4.8e-79 264.7 9.3 4.8e-79 264.7 9.3 3.1 3 1 1 4 4 4 1 X-domain of DnaJ-containing DnaJ PF00226.31 EMD65526.1 - 2.3e-26 91.7 0.4 2.3e-26 91.7 0.4 2.2 2 0 0 2 2 2 1 DnaJ domain OrfB_IS605 PF01385.19 EMD65526.1 - 0.014 15.6 1.6 0.04 14.1 1.6 1.7 1 0 0 1 1 1 0 Probable transposase AAR2 PF05282.11 EMD65526.1 - 0.12 11.8 5.0 3.2 7.1 0.2 2.3 2 0 0 2 2 2 0 AAR2 protein DUF2486 PF10667.9 EMD65526.1 - 0.15 12.3 22.7 0.03 14.5 18.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2486) Carb_anhydrase PF00194.21 EMD65527.1 - 9.3e-36 123.7 0.0 1.3e-35 123.2 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase RSN1_7TM PF02714.15 EMD65528.1 - 2.4e-72 243.5 14.9 2.4e-72 243.5 14.9 1.6 2 0 0 2 2 2 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 EMD65528.1 - 1.9e-39 134.9 3.8 4e-39 133.9 3.8 1.6 1 0 0 1 1 1 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 EMD65528.1 - 2.8e-39 135.2 0.0 4.4e-39 134.5 0.0 1.3 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter Spt5-NGN PF03439.13 EMD65529.1 - 7.6e-18 64.2 0.0 1.4e-17 63.4 0.0 1.5 1 0 0 1 1 1 1 Early transcription elongation factor of RNA pol II, NGN section Spt5_N PF11942.8 EMD65529.1 - 7.1e-14 52.6 13.0 7.1e-14 52.6 13.0 3.9 2 1 0 2 2 2 1 Spt5 transcription elongation factor, acidic N-terminal CTD PF12815.7 EMD65529.1 - 0.00018 22.0 55.9 0.0035 17.9 8.0 4.3 1 1 1 2 2 2 1 Spt5 C-terminal nonapeptide repeat binding Spt4 KOW PF00467.29 EMD65529.1 - 0.00043 20.1 16.6 0.17 11.9 0.1 5.6 6 0 0 6 6 6 2 KOW motif DUF3912 PF13051.6 EMD65529.1 - 0.036 14.3 0.6 0.11 12.7 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3912) Cornifin PF02389.15 EMD65529.1 - 0.066 13.4 3.9 0.11 12.7 3.9 1.2 1 0 0 1 1 1 0 Cornifin (SPRR) family DUF1506 PF07405.11 EMD65529.1 - 0.09 13.0 0.1 0.17 12.1 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1506) SDA1 PF05285.12 EMD65529.1 - 4.5 6.6 33.8 12 5.2 33.8 1.7 1 0 0 1 1 1 0 SDA1 ADH_zinc_N PF00107.26 EMD65530.1 - 6.4e-32 110.3 1.0 1.3e-31 109.3 1.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EMD65530.1 - 7.8e-13 49.6 0.2 1.6e-12 48.7 0.2 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EMD65530.1 - 4e-06 26.7 0.0 1e-05 25.3 0.0 1.8 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ATP-synt_F PF01990.17 EMD65530.1 - 0.0089 16.3 0.1 0.019 15.3 0.1 1.5 1 0 0 1 1 1 1 ATP synthase (F/14-kDa) subunit adh_short PF00106.25 EMD65530.1 - 0.012 15.1 2.3 0.019 14.4 2.3 1.3 1 0 0 1 1 1 0 short chain dehydrogenase Eno-Rase_NADH_b PF12242.8 EMD65530.1 - 0.013 15.3 0.5 0.023 14.4 0.5 1.5 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase TrkA_N PF02254.18 EMD65530.1 - 0.025 14.8 0.2 0.063 13.5 0.2 1.6 1 0 0 1 1 1 0 TrkA-N domain NmrA PF05368.13 EMD65530.1 - 0.078 12.5 0.7 0.12 12.0 0.7 1.2 1 0 0 1 1 1 0 NmrA-like family AlaDh_PNT_C PF01262.21 EMD65530.1 - 0.086 12.1 4.1 0.14 11.4 4.1 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Abhydrolase_6 PF12697.7 EMD65531.1 - 1.9e-05 25.4 0.0 2.6e-05 24.9 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EMD65531.1 - 4e-05 23.0 0.0 0.00011 21.6 0.0 1.7 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EMD65531.1 - 0.0074 16.0 0.3 0.03 14.0 0.3 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S28 PF05577.12 EMD65531.1 - 0.13 11.0 0.0 0.24 10.1 0.0 1.4 1 0 0 1 1 1 0 Serine carboxypeptidase S28 Isochorismatase PF00857.20 EMD65532.1 - 7e-15 55.6 0.0 1.2e-14 54.9 0.0 1.4 1 0 0 1 1 1 1 Isochorismatase family Fungal_trans_2 PF11951.8 EMD65534.1 - 8.5e-34 117.0 0.0 1.1e-33 116.6 0.0 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD65534.1 - 8.8e-07 29.0 8.7 1.5e-06 28.2 8.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SUR7 PF06687.12 EMD65535.1 - 8.4e-28 97.4 5.8 1.2e-27 97.0 5.8 1.1 1 0 0 1 1 1 1 SUR7/PalI family Shisa PF13908.6 EMD65535.1 - 1.9 8.7 4.1 18 5.5 0.0 2.4 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator Ribosomal_S4e PF00900.20 EMD65536.1 - 6.4e-38 128.5 0.4 1.4e-37 127.4 0.4 1.6 1 0 0 1 1 1 1 Ribosomal family S4e 40S_S4_C PF16121.5 EMD65536.1 - 4.8e-22 77.3 0.1 8.7e-22 76.5 0.1 1.5 1 0 0 1 1 1 1 40S ribosomal protein S4 C-terminus RS4NT PF08071.12 EMD65536.1 - 1.8e-16 59.9 5.0 3.3e-16 59.1 5.0 1.4 1 0 0 1 1 1 1 RS4NT (NUC023) domain S4 PF01479.25 EMD65536.1 - 9e-07 28.5 0.0 1.8e-06 27.6 0.0 1.5 1 0 0 1 1 1 1 S4 domain KOW PF00467.29 EMD65536.1 - 5.9e-05 22.9 4.7 5.9e-05 22.9 4.7 3.1 4 0 0 4 4 4 1 KOW motif Semialdhyde_dhC PF02774.18 EMD65537.1 - 2.7e-41 141.7 0.0 3.5e-41 141.3 0.0 1.1 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, dimerisation domain Semialdhyde_dh PF01118.24 EMD65537.1 - 1.6e-29 102.8 0.0 4.9e-29 101.2 0.0 1.8 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain GFO_IDH_MocA PF01408.22 EMD65537.1 - 0.11 13.3 0.0 0.24 12.2 0.0 1.5 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold FAD-oxidase_C PF02913.19 EMD65538.1 - 8.9e-67 225.3 0.2 1.5e-66 224.6 0.2 1.4 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 EMD65538.1 - 5e-32 110.5 0.0 9.2e-32 109.7 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain MR_MLE_C PF13378.6 EMD65538.1 - 0.0083 15.7 0.2 2.1 7.8 0.0 2.7 3 0 0 3 3 3 2 Enolase C-terminal domain-like DUF3584 PF12128.8 EMD65539.1 - 0.00024 18.8 69.2 0.0025 15.5 30.3 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF3584) DUF3439 PF11921.8 EMD65539.1 - 0.0035 17.3 0.0 0.02 14.8 0.0 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF3439) Spc7 PF08317.11 EMD65539.1 - 0.019 13.9 69.7 0.074 11.9 24.6 3.3 1 1 1 3 3 3 0 Spc7 kinetochore protein GAS PF13851.6 EMD65539.1 - 0.25 10.7 67.8 2.7 7.3 30.9 3.4 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding EzrA PF06160.12 EMD65539.1 - 0.27 9.3 54.6 0.84 7.7 30.1 3.2 1 1 0 2 2 2 0 Septation ring formation regulator, EzrA LtuB PF17455.2 EMD65539.1 - 0.53 10.9 4.2 3.3 8.4 0.7 2.9 2 0 0 2 2 2 0 Late transcription unit B PID_2 PF14719.6 EMD65539.1 - 2.5 7.9 6.7 0.22 11.4 0.6 2.3 2 0 0 2 2 2 0 Phosphotyrosine interaction domain (PTB/PID) MCM_N PF14551.6 EMD65539.1 - 2.6 8.7 9.2 1.7 9.3 6.1 2.4 2 0 0 2 2 2 0 MCM N-terminal domain TPR_MLP1_2 PF07926.12 EMD65539.1 - 3.7 7.6 77.2 0.27 11.3 14.9 4.8 1 1 2 4 4 4 0 TPR/MLP1/MLP2-like protein PspA_IM30 PF04012.12 EMD65539.1 - 7.6 6.0 63.7 3.6 7.1 28.4 3.4 1 1 2 3 3 3 0 PspA/IM30 family FMO-like PF00743.19 EMD65540.1 - 3.6e-14 52.1 0.4 1.9e-13 49.7 0.1 2.0 2 1 0 2 2 2 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EMD65540.1 - 1.1e-10 41.3 0.1 7.1e-06 25.5 0.0 3.2 3 1 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EMD65540.1 - 1.3e-10 41.0 0.4 2.5e-07 30.2 0.0 3.1 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.14 EMD65540.1 - 2.1e-08 33.8 0.0 0.0047 16.2 0.0 2.6 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EMD65540.1 - 1.6e-07 31.3 1.2 1.9e-05 24.5 1.2 2.6 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EMD65540.1 - 5.8e-07 29.6 0.0 1.2e-06 28.6 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 EMD65540.1 - 2.2e-05 24.5 0.2 0.049 13.6 0.1 2.7 2 1 0 2 2 2 2 FAD-NAD(P)-binding Lycopene_cycl PF05834.12 EMD65540.1 - 0.0016 17.6 0.3 0.049 12.7 0.1 2.1 2 0 0 2 2 2 1 Lycopene cyclase protein GIDA PF01134.22 EMD65540.1 - 0.0044 16.2 0.1 0.077 12.1 0.0 2.1 2 0 0 2 2 2 1 Glucose inhibited division protein A Thi4 PF01946.17 EMD65540.1 - 0.018 14.3 0.0 0.099 11.9 0.0 2.1 2 0 0 2 2 2 0 Thi4 family Mqo PF06039.15 EMD65540.1 - 0.031 12.8 0.2 0.46 9.0 0.0 2.3 3 0 0 3 3 3 0 Malate:quinone oxidoreductase (Mqo) HI0933_like PF03486.14 EMD65540.1 - 0.16 10.7 0.2 14 4.3 0.0 2.6 3 0 0 3 3 3 0 HI0933-like protein ABC2_membrane PF01061.24 EMD65541.1 - 3.9e-40 137.5 21.5 6.5e-40 136.8 21.5 1.4 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 EMD65541.1 - 8.2e-28 97.6 0.0 1.5e-27 96.8 0.0 1.4 1 0 0 1 1 1 1 ABC transporter ABC2_membrane_3 PF12698.7 EMD65541.1 - 3.4e-08 33.0 27.0 3.4e-08 33.0 27.0 2.2 1 1 1 2 2 2 1 ABC-2 family transporter protein AAA_21 PF13304.6 EMD65541.1 - 6.4e-06 26.2 0.1 0.14 12.0 0.0 2.6 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_24 PF13479.6 EMD65541.1 - 0.021 14.5 0.1 0.056 13.2 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 EMD65541.1 - 0.034 13.9 0.1 0.071 12.9 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_18 PF13238.6 EMD65541.1 - 0.049 14.2 0.0 0.14 12.7 0.0 1.8 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 EMD65541.1 - 0.068 13.1 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain RsgA_GTPase PF03193.16 EMD65541.1 - 0.1 12.5 0.0 0.2 11.6 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase AAA_16 PF13191.6 EMD65541.1 - 0.19 12.1 0.0 0.34 11.3 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_25 PF13481.6 EMD65541.1 - 0.29 10.7 0.4 0.62 9.6 0.1 1.6 2 0 0 2 2 2 0 AAA domain ABC2_membrane_2 PF12679.7 EMD65541.1 - 5.2 6.3 17.4 29 3.8 17.4 2.0 1 1 0 1 1 1 0 ABC-2 family transporter protein Aminotran_1_2 PF00155.21 EMD65542.1 - 1.6e-41 142.7 0.0 2.1e-41 142.3 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 EMD65542.1 - 1.9e-07 30.4 0.0 8.3e-07 28.3 0.0 1.8 2 0 0 2 2 2 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 EMD65542.1 - 2e-06 26.6 0.0 2.9e-06 26.1 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Beta_elim_lyase PF01212.21 EMD65542.1 - 0.00012 21.5 0.0 0.0002 20.7 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 EMD65542.1 - 0.029 13.7 0.0 0.062 12.6 0.0 1.5 2 0 0 2 2 2 0 DegT/DnrJ/EryC1/StrS aminotransferase family Alliinase_C PF04864.13 EMD65542.1 - 0.043 12.7 0.2 0.44 9.3 0.1 2.2 1 1 1 2 2 2 0 Allinase Biotin_lipoyl PF00364.22 EMD65545.1 - 5.9e-21 74.1 0.3 1.3e-20 73.0 0.3 1.6 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 EMD65545.1 - 2.6e-08 34.0 0.0 9.3e-08 32.3 0.0 2.0 1 0 0 1 1 1 1 e3 binding domain Biotin_lipoyl_2 PF13533.6 EMD65545.1 - 3.1e-05 23.7 0.5 0.00097 18.9 0.0 3.0 2 1 1 3 3 3 1 Biotin-lipoyl like E1-E2_ATPase PF00122.20 EMD65546.1 - 8.2e-39 133.0 17.3 2e-32 112.2 0.2 3.4 3 0 0 3 3 3 2 E1-E2 ATPase Cation_ATPase_C PF00689.21 EMD65546.1 - 2e-25 89.6 9.0 2e-25 89.6 9.0 2.5 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 EMD65546.1 - 2.1e-19 70.7 0.1 2.7e-16 60.5 0.0 2.8 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EMD65546.1 - 3e-18 65.7 0.0 5.7e-18 64.8 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 EMD65546.1 - 1.6e-15 56.5 0.0 3.6e-15 55.4 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EMD65546.1 - 4.2e-05 23.4 0.1 0.00047 20.0 0.2 2.1 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF2463 PF09591.10 EMD65546.1 - 0.11 12.4 2.0 0.22 11.4 2.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2463) TauD PF02668.16 EMD65547.1 - 1.5e-61 208.6 0.4 1.9e-61 208.3 0.4 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family FMO-like PF00743.19 EMD65548.1 - 7.9e-30 103.8 0.2 9.5e-21 73.8 0.1 2.8 2 1 0 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EMD65548.1 - 7.9e-16 58.2 0.1 1.2e-14 54.3 0.1 2.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EMD65548.1 - 6.4e-13 48.6 0.0 2.9e-12 46.4 0.0 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EMD65548.1 - 7.6e-10 38.9 0.0 1.8e-09 37.7 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EMD65548.1 - 1.2e-09 38.2 3.5 8.5e-05 22.3 1.8 3.2 3 0 0 3 3 3 3 FAD dependent oxidoreductase K_oxygenase PF13434.6 EMD65548.1 - 1.7e-06 27.5 0.5 0.00039 19.7 0.0 2.7 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 EMD65548.1 - 1.9e-06 28.0 1.0 0.0025 17.8 0.1 3.5 2 1 1 3 3 3 1 FAD-NAD(P)-binding Amino_oxidase PF01593.24 EMD65548.1 - 3.5e-05 23.3 0.4 0.022 14.1 0.1 2.3 1 1 1 2 2 2 2 Flavin containing amine oxidoreductase Pyr_redox PF00070.27 EMD65548.1 - 5.1e-05 23.7 0.2 0.001 19.6 0.4 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EMD65548.1 - 0.00026 20.3 0.0 0.0005 19.4 0.0 1.4 1 0 0 1 1 1 1 Thi4 family HI0933_like PF03486.14 EMD65548.1 - 0.00045 19.0 1.0 0.0017 17.1 0.9 1.8 2 0 0 2 2 2 1 HI0933-like protein FAD_binding_2 PF00890.24 EMD65548.1 - 0.0017 17.5 0.8 0.0043 16.2 0.7 1.7 2 0 0 2 2 2 1 FAD binding domain GIDA PF01134.22 EMD65548.1 - 0.0023 17.1 0.4 0.0051 15.9 0.4 1.6 1 0 0 1 1 1 1 Glucose inhibited division protein A Shikimate_DH PF01488.20 EMD65548.1 - 0.013 15.6 0.1 0.028 14.5 0.1 1.6 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase FAD_oxidored PF12831.7 EMD65548.1 - 0.013 14.8 0.0 0.024 14.0 0.0 1.6 1 0 0 1 1 1 0 FAD dependent oxidoreductase 3HCDH_N PF02737.18 EMD65548.1 - 0.014 15.2 0.1 0.027 14.4 0.1 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 EMD65548.1 - 0.017 14.4 0.1 0.029 13.7 0.1 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain IlvN PF07991.12 EMD65548.1 - 0.043 13.4 0.1 0.081 12.5 0.1 1.4 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain FAD_binding_3 PF01494.19 EMD65548.1 - 0.048 12.9 0.8 0.094 11.9 0.1 1.7 2 0 0 2 2 2 0 FAD binding domain NAD_binding_2 PF03446.15 EMD65548.1 - 0.089 13.0 0.0 0.2 11.8 0.0 1.6 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase ApbA PF02558.16 EMD65548.1 - 0.098 12.3 0.3 0.3 10.7 0.3 1.8 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA MFS_1 PF07690.16 EMD65549.1 - 1.9e-34 119.2 5.9 1.9e-34 119.2 5.9 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily MFS_4 PF06779.14 EMD65549.1 - 0.0059 16.0 0.3 0.057 12.7 0.1 2.1 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB PQ-loop PF04193.14 EMD65550.1 - 2.7e-34 116.7 8.3 1.1e-17 63.6 0.3 2.6 2 0 0 2 2 2 2 PQ loop repeat Polyketide_cyc2 PF10604.9 EMD65551.1 - 0.0002 21.7 0.2 0.00074 19.8 0.0 2.0 2 0 0 2 2 2 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc PF03364.20 EMD65551.1 - 0.002 18.3 0.0 0.0035 17.6 0.0 1.5 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport PALP PF00291.25 EMD65553.1 - 8.2e-78 261.8 0.3 1.5e-77 260.9 0.2 1.5 2 0 0 2 2 2 1 Pyridoxal-phosphate dependent enzyme Thr_dehydrat_C PF00585.18 EMD65553.1 - 5e-43 144.8 0.0 2.4e-20 72.1 0.0 2.3 2 0 0 2 2 2 2 C-terminal regulatory domain of Threonine dehydratase Septin PF00735.18 EMD65555.1 - 1.2e-34 119.9 0.0 2e-11 43.7 0.0 3.2 3 0 0 3 3 3 3 Septin FtsK_SpoIIIE PF01580.18 EMD65555.1 - 0.0052 16.2 0.0 0.01 15.2 0.0 1.4 1 0 0 1 1 1 1 FtsK/SpoIIIE family Dynamin_N PF00350.23 EMD65555.1 - 0.0079 16.3 0.2 0.067 13.2 0.0 2.3 2 0 0 2 2 2 1 Dynamin family AAA_16 PF13191.6 EMD65555.1 - 0.018 15.5 0.1 0.098 13.0 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain AAA_23 PF13476.6 EMD65555.1 - 0.038 14.5 2.0 0.17 12.3 1.4 2.3 2 1 0 2 2 2 0 AAA domain IIGP PF05049.13 EMD65555.1 - 0.052 12.6 0.0 0.11 11.5 0.0 1.4 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) AAA_29 PF13555.6 EMD65555.1 - 0.055 13.2 0.0 0.13 12.1 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_21 PF13304.6 EMD65555.1 - 0.088 12.6 0.9 5.4 6.7 0.5 2.3 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system adh_short PF00106.25 EMD65556.1 - 3.1e-11 43.1 0.0 5.4e-11 42.3 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EMD65556.1 - 2.5e-07 30.8 0.0 4.3e-07 30.0 0.0 1.3 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.6 EMD65556.1 - 5.2e-05 22.9 0.0 8.3e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Yae1_N PF09811.9 EMD65557.1 - 1.7e-11 43.6 2.3 2.6e-11 43.0 2.3 1.3 1 0 0 1 1 1 1 Essential protein Yae1, N terminal ABC1 PF03109.16 EMD65558.1 - 6.5e-21 74.7 0.0 1.7e-20 73.4 0.0 1.7 1 0 0 1 1 1 1 ABC1 family ECH_1 PF00378.20 EMD65559.1 - 9.5e-30 103.7 0.0 1.3e-29 103.2 0.0 1.3 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EMD65559.1 - 7.3e-16 58.6 0.0 8.1e-16 58.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase DUF4875 PF16175.5 EMD65559.1 - 0.1 12.8 0.0 0.39 10.9 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4875) FAA_hydrolase PF01557.18 EMD65560.1 - 4.6e-54 183.4 0.0 5.5e-54 183.1 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family E1-E2_ATPase PF00122.20 EMD65561.1 - 2.9e-41 141.0 0.6 2.9e-41 141.0 0.6 2.8 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 EMD65561.1 - 3.6e-38 131.1 7.9 3.6e-38 131.1 7.9 2.9 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 EMD65561.1 - 3.4e-21 76.5 2.1 6.4e-18 65.8 2.1 3.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EMD65561.1 - 1.6e-16 60.1 0.0 3.6e-16 59.0 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 EMD65561.1 - 7.8e-12 44.7 2.1 1.1e-11 44.3 0.0 2.4 3 0 0 3 3 3 1 Cation transporter/ATPase, N-terminus DUF2157 PF09925.9 EMD65561.1 - 0.0003 20.6 3.0 0.028 14.2 0.0 3.5 3 0 0 3 3 3 1 Predicted membrane protein (DUF2157) Hydrolase_3 PF08282.12 EMD65561.1 - 0.00052 19.8 0.2 0.001 18.9 0.2 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HTH_11 PF08279.12 EMD65561.1 - 0.012 15.6 0.0 0.039 13.9 0.0 1.8 1 0 0 1 1 1 0 HTH domain p450 PF00067.22 EMD65562.1 - 9e-44 150.0 0.0 6.1e-41 140.6 0.0 2.0 1 1 0 1 1 1 1 Cytochrome P450 Copine PF07002.16 EMD65562.1 - 0.17 11.4 0.0 0.42 10.0 0.0 1.6 2 0 0 2 2 2 0 Copine DUF1996 PF09362.10 EMD65563.1 - 2.7e-71 240.3 0.1 3.6e-71 239.9 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1996) CDH-cyt PF16010.5 EMD65564.1 - 5.9e-48 163.0 5.1 8.4e-48 162.5 3.6 1.7 2 0 0 2 2 2 1 Cytochrome domain of cellobiose dehydrogenase FAD_binding_3 PF01494.19 EMD65565.1 - 1.1e-23 84.1 0.0 1.6e-23 83.6 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain SE PF08491.10 EMD65565.1 - 0.00033 19.8 0.0 0.00075 18.6 0.0 1.5 2 0 0 2 2 2 1 Squalene epoxidase Pyr_redox_2 PF07992.14 EMD65565.1 - 0.00047 19.5 0.0 0.0016 17.8 0.0 1.7 1 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EMD65565.1 - 0.00052 20.5 0.1 0.022 15.3 0.0 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EMD65565.1 - 0.00097 19.3 0.2 0.0026 17.9 0.2 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 EMD65565.1 - 0.0021 17.2 0.0 0.0033 16.6 0.0 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A DAO PF01266.24 EMD65565.1 - 0.015 14.9 0.2 0.037 13.6 0.1 1.7 2 0 0 2 2 2 0 FAD dependent oxidoreductase HI0933_like PF03486.14 EMD65565.1 - 0.016 14.0 0.0 0.023 13.4 0.0 1.2 1 0 0 1 1 1 0 HI0933-like protein AlaDh_PNT_C PF01262.21 EMD65565.1 - 0.02 14.2 0.0 0.034 13.5 0.0 1.5 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain 3HCDH_N PF02737.18 EMD65565.1 - 0.03 14.2 0.0 0.055 13.4 0.0 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Peptidase_M24 PF00557.24 EMD65566.1 - 4.9e-45 153.8 0.1 6.1e-45 153.5 0.1 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 zf-C6H2 PF15801.5 EMD65566.1 - 6.9e-19 67.9 11.1 1.5e-18 66.8 11.1 1.6 1 0 0 1 1 1 1 zf-MYND-like zinc finger, mRNA-binding zf-MYND PF01753.18 EMD65566.1 - 0.00094 19.2 10.0 0.00094 19.2 10.0 2.3 2 0 0 2 2 2 1 MYND finger DUF2116 PF09889.9 EMD65566.1 - 0.094 12.7 1.4 0.21 11.6 1.4 1.5 1 0 0 1 1 1 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) Nore1-SARAH PF16517.5 EMD65566.1 - 0.2 11.6 0.1 0.39 10.7 0.1 1.4 1 0 0 1 1 1 0 Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain zf-HIT PF04438.16 EMD65566.1 - 0.41 10.5 6.3 1.2 9.1 6.3 1.9 1 0 0 1 1 1 0 HIT zinc finger Cornichon PF03311.14 EMD65567.1 - 8.3e-51 171.4 13.7 9.5e-51 171.2 13.7 1.0 1 0 0 1 1 1 1 Cornichon protein WD40 PF00400.32 EMD65568.1 - 2.5e-28 97.7 2.5 5.7e-08 33.3 0.0 6.9 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD65568.1 - 4.5e-13 49.3 0.0 0.017 15.4 0.0 5.0 2 2 2 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Coatomer_WDAD PF04053.14 EMD65568.1 - 0.021 13.9 0.0 0.38 9.8 0.0 2.5 2 1 0 3 3 3 0 Coatomer WD associated region Chromate_transp PF02417.15 EMD65570.1 - 4.7e-64 215.3 32.7 1.5e-34 119.4 16.1 2.3 2 0 0 2 2 2 2 Chromate transporter DJ-1_PfpI PF01965.24 EMD65571.1 - 3.9e-14 52.8 0.1 5.9e-14 52.2 0.1 1.3 1 0 0 1 1 1 1 DJ-1/PfpI family ThiJ_like PF17124.5 EMD65571.1 - 3.7e-06 26.8 0.0 5.1e-06 26.3 0.0 1.2 1 0 0 1 1 1 1 ThiJ/PfpI family-like PIG-S PF10510.9 EMD65572.1 - 3.6e-175 583.7 4.8 4.2e-175 583.5 4.8 1.0 1 0 0 1 1 1 1 Phosphatidylinositol-glycan biosynthesis class S protein Beta-lactamase PF00144.24 EMD65573.1 - 3.9e-38 131.5 0.2 1.7e-37 129.5 0.2 1.7 1 1 0 1 1 1 1 Beta-lactamase Peptidase_S11 PF00768.20 EMD65573.1 - 0.15 11.5 0.1 0.2 11.0 0.1 1.2 1 0 0 1 1 1 0 D-alanyl-D-alanine carboxypeptidase DUF1932 PF09130.11 EMD65574.1 - 6.4e-23 80.5 0.0 1.5e-22 79.3 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1932) NAD_binding_2 PF03446.15 EMD65574.1 - 8.4e-06 26.0 0.2 2.8e-05 24.3 0.1 2.0 2 1 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 EMD65574.1 - 6.9e-05 23.3 0.1 0.00013 22.5 0.1 1.4 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Rossmann-like PF10727.9 EMD65574.1 - 0.018 14.9 0.2 0.038 13.8 0.2 1.5 1 0 0 1 1 1 0 Rossmann-like domain IlvN PF07991.12 EMD65574.1 - 0.029 13.9 0.1 0.056 13.0 0.1 1.4 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain 2-Hacid_dh_C PF02826.19 EMD65574.1 - 0.074 12.4 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain MARVEL PF01284.23 EMD65576.1 - 1.3e-12 47.9 16.6 1.6e-12 47.7 16.6 1.1 1 0 0 1 1 1 1 Membrane-associating domain DLH PF01738.18 EMD65577.1 - 0.093 12.3 0.0 0.15 11.6 0.0 1.4 1 1 0 1 1 1 0 Dienelactone hydrolase family PIP5K PF01504.18 EMD65578.1 - 1.3e-38 132.9 3.4 3.7e-31 108.4 0.9 2.6 1 1 1 2 2 2 2 Phosphatidylinositol-4-phosphate 5-Kinase Cpn60_TCP1 PF00118.24 EMD65578.1 - 6.5e-32 110.8 0.0 1.2e-31 110.0 0.0 1.3 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family FYVE PF01363.21 EMD65578.1 - 7.5e-14 51.6 7.2 7.5e-14 51.6 7.2 2.1 2 0 0 2 2 2 1 FYVE zinc finger Apo-CIII PF05778.12 EMD65578.1 - 0.17 11.5 0.2 0.74 9.5 0.2 2.1 1 0 0 1 1 1 0 Apolipoprotein CIII (Apo-CIII) C1_1 PF00130.22 EMD65578.1 - 0.46 10.4 7.7 0.11 12.4 3.9 2.0 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) TPP1 PF10341.9 EMD65579.1 - 0.011 15.7 0.0 0.034 14.1 0.0 1.8 1 0 0 1 1 1 0 Shelterin complex subunit, TPP1/ACD p450 PF00067.22 EMD65580.1 - 1.1e-52 179.4 0.0 1.5e-52 178.9 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 MFS_1 PF07690.16 EMD65580.1 - 7.3e-18 64.6 33.2 2e-10 40.2 8.5 3.3 3 0 0 3 3 3 3 Major Facilitator Superfamily MFS_1_like PF12832.7 EMD65580.1 - 0.011 14.7 1.0 1.8 7.4 0.2 2.3 2 0 0 2 2 2 0 MFS_1 like family UPF0489 PF12640.7 EMD65580.1 - 0.21 11.8 0.0 0.38 11.0 0.0 1.3 1 0 0 1 1 1 0 UPF0489 domain F-box-like PF12937.7 EMD65581.1 - 5.2e-08 32.7 1.2 1.2e-07 31.5 1.2 1.7 1 0 0 1 1 1 1 F-box-like F-box_4 PF15966.5 EMD65581.1 - 6.1e-06 26.1 0.5 1.4e-05 24.9 0.5 1.6 1 0 0 1 1 1 1 F-box F-box PF00646.33 EMD65581.1 - 0.00047 20.0 1.9 0.00076 19.3 0.2 2.2 2 0 0 2 2 2 1 F-box domain Ribosomal_L37e PF01907.19 EMD65582.1 - 1.2e-27 95.8 11.9 1.9e-27 95.1 11.9 1.3 1 0 0 1 1 1 1 Ribosomal protein L37e DZR PF12773.7 EMD65582.1 - 0.0038 17.2 1.6 0.0061 16.6 1.6 1.2 1 0 0 1 1 1 1 Double zinc ribbon HypA PF01155.19 EMD65582.1 - 0.13 12.3 0.5 0.17 11.9 0.5 1.2 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF2688 PF10892.8 EMD65582.1 - 1.9 8.0 5.6 12 5.4 3.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2688) Sugar_tr PF00083.24 EMD65583.1 - 8.5e-43 146.9 21.2 1.2e-42 146.4 21.2 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD65583.1 - 2.5e-22 79.3 39.2 2.1e-19 69.7 23.3 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1 PF07690.16 EMD65584.1 - 1.7e-27 96.3 61.8 4.5e-24 85.0 40.5 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF5353 PF17304.2 EMD65584.1 - 0.55 10.0 5.1 7.7 6.4 0.5 3.2 2 0 0 2 2 2 0 Family of unknown function (DUF5353) SAP PF02037.27 EMD65585.1 - 1.7e-11 43.6 0.4 3e-11 42.8 0.4 1.4 1 0 0 1 1 1 1 SAP domain Tho1_MOS11_C PF18592.1 EMD65585.1 - 2.1e-05 24.2 4.4 2.1e-05 24.2 4.4 2.1 3 0 0 3 3 3 1 Tho1/MOS11 C-terminal domain DUF445 PF04286.12 EMD65586.1 - 0.047 13.5 1.0 0.053 13.3 1.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF445) RNA_pol_Rpb5_C PF01191.19 EMD65586.1 - 0.088 12.7 0.2 0.16 11.9 0.2 1.4 1 0 0 1 1 1 0 RNA polymerase Rpb5, C-terminal domain Romo1 PF10247.9 EMD65588.1 - 2.9e-26 91.6 13.9 3.7e-26 91.3 13.9 1.1 1 0 0 1 1 1 1 Reactive mitochondrial oxygen species modulator 1 Tim17 PF02466.19 EMD65588.1 - 0.0084 16.5 2.8 0.0099 16.3 2.8 1.2 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Form-deh_trans PF09163.11 EMD65588.1 - 2 8.3 5.9 6.6 6.6 0.3 2.4 2 0 0 2 2 2 0 Formate dehydrogenase N, transmembrane FHA PF00498.26 EMD65589.1 - 3.3e-16 59.4 0.1 8e-16 58.1 0.1 1.7 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 EMD65589.1 - 0.001 19.4 0.0 0.0031 17.8 0.0 1.8 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain Hormone_1 PF00103.20 EMD65589.1 - 0.017 14.9 0.7 0.017 14.9 0.7 1.6 2 0 0 2 2 2 0 Somatotropin hormone family YhfZ_C PF14503.6 EMD65589.1 - 0.056 13.0 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 YhfZ C-terminal domain Rpp20 PF12328.8 EMD65590.1 - 7.1e-34 116.7 0.0 1.5e-33 115.7 0.0 1.5 1 0 0 1 1 1 1 Rpp20 subunit of nuclear RNase MRP and P Alba PF01918.21 EMD65590.1 - 1.7e-07 30.9 0.0 3.1e-07 30.1 0.0 1.4 1 0 0 1 1 1 1 Alba Opi1 PF08618.10 EMD65590.1 - 3.7 6.7 9.7 5.9 6.0 9.7 1.2 1 0 0 1 1 1 0 Transcription factor Opi1 BPL_LplA_LipB PF03099.19 EMD65591.1 - 3.2e-10 40.0 0.0 4.7e-10 39.5 0.0 1.2 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family RRM_1 PF00076.22 EMD65592.1 - 1.3e-10 40.9 0.0 3.7e-10 39.5 0.0 1.7 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ANAPC4_WD40 PF12894.7 EMD65594.1 - 4.2e-05 23.8 0.0 0.0017 18.6 0.0 3.0 3 1 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EMD65594.1 - 0.00015 22.5 1.7 0.35 11.8 0.1 4.1 4 0 0 4 4 4 1 WD domain, G-beta repeat LisH PF08513.11 EMD65594.1 - 0.00032 20.5 0.0 0.00071 19.4 0.0 1.6 1 0 0 1 1 1 1 LisH LisH_2 PF16045.5 EMD65594.1 - 0.0081 15.2 0.0 0.017 14.2 0.0 1.6 1 0 0 1 1 1 1 LisH PQQ_2 PF13360.6 EMD65594.1 - 0.054 13.1 0.6 1.9 8.0 0.2 2.4 1 1 0 2 2 2 0 PQQ-like domain Ge1_WD40 PF16529.5 EMD65594.1 - 0.06 12.3 0.1 1.1 8.2 0.0 2.1 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein SET PF00856.28 EMD65595.1 - 6.5e-08 33.1 0.0 1.8e-07 31.7 0.0 1.7 1 1 0 1 1 1 1 SET domain zf-MYND PF01753.18 EMD65595.1 - 0.0021 18.1 7.9 0.0083 16.2 7.9 2.1 1 0 0 1 1 1 1 MYND finger Septin PF00735.18 EMD65596.1 - 1.2e-15 57.5 0.0 3.8e-11 42.8 0.0 2.2 2 0 0 2 2 2 2 Septin MMR_HSR1 PF01926.23 EMD65596.1 - 7.8e-07 29.2 0.0 2e-06 27.9 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 EMD65596.1 - 0.0018 18.4 0.3 0.013 15.6 0.1 2.5 2 1 0 2 2 2 1 Dynamin family AAA_16 PF13191.6 EMD65596.1 - 0.0053 17.2 0.0 0.016 15.6 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain Roc PF08477.13 EMD65596.1 - 0.0077 16.4 0.1 0.019 15.1 0.1 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_7 PF12775.7 EMD65596.1 - 0.0094 15.5 0.1 0.017 14.7 0.1 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region RsgA_GTPase PF03193.16 EMD65596.1 - 0.011 15.6 0.0 0.026 14.4 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase ABC_tran PF00005.27 EMD65596.1 - 0.021 15.3 0.0 0.073 13.6 0.0 1.9 2 0 0 2 2 2 0 ABC transporter Sigma54_activat PF00158.26 EMD65596.1 - 0.026 14.2 0.0 0.046 13.4 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain DUF815 PF05673.13 EMD65596.1 - 0.032 13.4 0.0 0.054 12.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) NACHT PF05729.12 EMD65596.1 - 0.052 13.5 0.1 0.13 12.1 0.0 1.7 2 0 0 2 2 2 0 NACHT domain DUF87 PF01935.17 EMD65596.1 - 0.094 12.8 0.1 0.18 11.9 0.1 1.3 1 0 0 1 1 1 0 Helicase HerA, central domain AAA_22 PF13401.6 EMD65596.1 - 0.17 12.2 0.0 0.39 11.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain MCM PF00493.23 EMD65596.1 - 0.22 10.6 0.0 0.45 9.6 0.0 1.4 1 0 0 1 1 1 0 MCM P-loop domain NTF2 PF02136.20 EMD65597.1 - 3.1e-25 89.1 0.8 6.3e-25 88.1 0.8 1.6 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain RRM_1 PF00076.22 EMD65597.1 - 6.4e-08 32.3 0.0 1.1e-07 31.6 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 EMD65597.1 - 0.0097 15.9 0.0 0.03 14.4 0.0 1.8 1 0 0 1 1 1 1 RNA binding motif Baculo_PEP_C PF04513.12 EMD65598.1 - 0.0024 17.9 1.8 0.0042 17.1 1.8 1.3 1 0 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus FtsQ PF03799.15 EMD65598.1 - 0.035 14.9 0.4 0.079 13.8 0.4 1.6 1 0 0 1 1 1 0 Cell division protein FtsQ NPV_P10 PF05531.12 EMD65598.1 - 0.096 13.2 0.1 0.22 12.0 0.1 1.6 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein DUF4051 PF13260.6 EMD65598.1 - 0.11 12.2 1.4 0.29 10.9 1.4 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF4051) DUF948 PF06103.11 EMD65598.1 - 0.14 12.4 0.2 0.67 10.2 0.1 2.0 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Ca_hom_mod PF14798.6 EMD65598.1 - 0.27 10.3 3.2 1.6 7.8 0.6 2.0 1 1 1 2 2 2 0 Calcium homeostasis modulator FAD_binding_4 PF01565.23 EMD65599.1 - 2.3e-15 56.5 0.0 7.2e-15 55.0 0.0 1.7 2 0 0 2 2 2 1 FAD binding domain Git3 PF11710.8 EMD65601.1 - 8e-18 65.0 14.7 8e-18 65.0 14.7 1.6 2 0 0 2 2 2 1 G protein-coupled glucose receptor regulating Gpa2 GPR_Gpa2_C PF11970.8 EMD65601.1 - 2.7e-07 30.6 0.1 2.7e-07 30.6 0.1 2.3 3 0 0 3 3 3 1 G protein-coupled glucose receptor regulating Gpa2 C-term 7tm_1 PF00001.21 EMD65601.1 - 0.00032 20.1 9.9 0.00032 20.1 9.9 1.8 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) PGG PF13962.6 EMD65601.1 - 0.49 10.2 6.1 0.056 13.3 0.7 2.1 3 0 0 3 3 3 0 Domain of unknown function DUF996 PF06195.13 EMD65601.1 - 2.4 8.5 11.2 0.17 12.2 0.8 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF996) AAA_lid_6 PF17866.1 EMD65602.1 - 0.12 12.6 0.0 0.16 12.1 0.0 1.3 1 0 0 1 1 1 0 AAA lid domain DDE_1 PF03184.19 EMD65603.1 - 2.4e-26 92.4 0.0 2.8e-26 92.2 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.6 EMD65603.1 - 0.019 14.7 0.0 0.03 14.1 0.0 1.3 1 0 0 1 1 1 0 DDE superfamily endonuclease Ribosomal_S8 PF00410.19 EMD65607.1 - 2.1e-13 50.3 0.0 2.1e-11 43.9 0.0 2.8 1 1 0 1 1 1 1 Ribosomal protein S8 MARVEL PF01284.23 EMD65608.1 - 0.0015 18.6 15.2 0.0023 18.0 15.2 1.2 1 0 0 1 1 1 1 Membrane-associating domain DUF4293 PF14126.6 EMD65608.1 - 0.06 13.6 6.8 0.2 11.9 2.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4293) SelK_SelG PF10961.8 EMD65608.1 - 0.12 13.1 1.5 1.5 9.5 0.0 2.7 2 0 0 2 2 2 0 Selenoprotein SelK_SelG SUR7 PF06687.12 EMD65608.1 - 0.17 11.5 10.2 9 5.9 0.0 2.1 2 0 0 2 2 2 0 SUR7/PalI family IMS PF00817.20 EMD65610.1 - 2.4e-41 141.2 0.3 4e-41 140.5 0.3 1.4 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.8 EMD65610.1 - 2.7e-13 50.6 0.1 6.1e-13 49.5 0.1 1.6 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.8 EMD65610.1 - 0.00044 20.4 0.0 0.0013 18.9 0.0 1.9 1 0 0 1 1 1 1 IMS family HHH motif RGS12_us1 PF16613.5 EMD65610.1 - 0.0044 17.3 0.7 0.01 16.1 0.7 1.6 1 0 0 1 1 1 1 Unstructured region of RGS12 Vps36-NZF-N PF16988.5 EMD65610.1 - 0.068 12.6 1.2 0.13 11.7 0.1 2.0 2 0 0 2 2 2 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain SpoIIP PF07454.11 EMD65610.1 - 0.088 12.3 2.0 2.2 7.7 0.0 2.7 3 0 0 3 3 3 0 Stage II sporulation protein P (SpoIIP) AT_hook PF02178.19 EMD65610.1 - 0.79 9.8 6.8 3.9 7.7 2.0 2.7 2 0 0 2 2 2 0 AT hook motif Zip PF02535.22 EMD65612.1 - 4.4e-70 236.5 8.0 4.9e-70 236.4 8.0 1.0 1 0 0 1 1 1 1 ZIP Zinc transporter Bac_rhodopsin PF01036.18 EMD65613.1 - 2.7e-45 154.7 18.6 3.2e-45 154.4 18.6 1.0 1 0 0 1 1 1 1 Bacteriorhodopsin-like protein DUF1772 PF08592.11 EMD65613.1 - 0.67 10.3 13.4 6 7.2 0.3 2.9 1 1 0 2 2 2 0 Domain of unknown function (DUF1772) Phage_holin_3_6 PF07332.11 EMD65613.1 - 2.9 8.0 17.1 0.095 12.7 2.5 2.9 2 1 1 3 3 3 0 Putative Actinobacterial Holin-X, holin superfamily III DUF1129 PF06570.11 EMD65613.1 - 7.4 6.0 13.0 1.2 8.6 2.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) RPEL PF02755.15 EMD65614.1 - 6.2e-29 98.8 15.0 5.9e-10 38.5 0.3 3.4 3 0 0 3 3 3 3 RPEL repeat Sugar_tr PF00083.24 EMD65615.1 - 2e-116 389.6 21.0 2.2e-116 389.4 21.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD65615.1 - 5.6e-16 58.4 21.8 5.6e-16 58.4 21.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2264 PF10022.9 EMD65616.1 - 5.8e-142 473.0 1.9 8.4e-142 472.4 1.9 1.2 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2264) RVT_connect PF06815.13 EMD65616.1 - 0.02 15.1 1.0 0.054 13.8 1.0 1.7 1 0 0 1 1 1 0 Reverse transcriptase connection domain Pkinase PF00069.25 EMD65617.1 - 4e-75 252.6 0.0 4.9e-75 252.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD65617.1 - 4.2e-36 124.6 0.0 5.7e-36 124.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EMD65617.1 - 0.00019 20.5 0.0 0.00079 18.5 0.0 1.8 1 1 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EMD65617.1 - 0.014 14.8 0.3 0.039 13.3 0.3 1.7 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EMD65617.1 - 0.039 13.9 1.6 0.055 13.4 0.0 1.8 2 1 0 2 2 2 0 Phosphotransferase enzyme family Zn_clus PF00172.18 EMD65619.1 - 1.8e-09 37.6 7.4 3e-09 36.8 7.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EMD65619.1 - 0.0035 16.4 1.9 0.014 14.4 1.9 2.0 1 1 0 1 1 1 1 Fungal specific transcription factor domain Cytochrom_B561 PF03188.16 EMD65620.1 - 1e-08 35.4 7.5 2.2e-08 34.3 7.5 1.5 1 0 0 1 1 1 1 Eukaryotic cytochrome b561 DUF3611 PF12263.8 EMD65620.1 - 0.035 14.0 1.0 0.082 12.8 1.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3611) ANAPC_CDC26 PF10471.9 EMD65620.1 - 0.33 11.8 0.1 0.33 11.8 0.1 4.2 4 1 0 4 4 4 0 Anaphase-promoting complex APC subunit CDC26 Trp_oprn_chp PF09534.10 EMD65620.1 - 1 9.1 5.0 0.41 10.4 0.0 2.8 2 1 0 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) DUF4079 PF13301.6 EMD65620.1 - 1.5 8.9 8.7 26 5.0 1.8 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF4079) DUF2427 PF10348.9 EMD65620.1 - 2.4 8.0 8.7 0.32 10.8 3.8 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF2427) FA_desaturase PF00487.24 EMD65620.1 - 9 6.0 10.3 1.5 8.6 1.8 2.3 1 1 1 2 2 2 0 Fatty acid desaturase Spc7 PF08317.11 EMD65621.1 - 0.0016 17.4 12.3 0.0079 15.1 0.4 2.3 2 0 0 2 2 2 2 Spc7 kinetochore protein BLOC1_2 PF10046.9 EMD65621.1 - 0.011 16.0 1.1 0.011 16.0 1.1 2.7 3 0 0 3 3 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 KASH_CCD PF14662.6 EMD65621.1 - 0.012 15.5 0.9 0.012 15.5 0.9 2.4 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH DUF4407 PF14362.6 EMD65621.1 - 0.05 12.9 13.1 0.47 9.8 3.0 2.1 1 1 0 2 2 2 0 Domain of unknown function (DUF4407) Csm1_N PF18504.1 EMD65621.1 - 0.077 13.3 12.2 11 6.4 0.1 4.2 3 1 1 4 4 4 0 Csm1 N-terminal domain UPF0242 PF06785.11 EMD65621.1 - 0.1 12.7 10.1 0.052 13.7 7.7 1.8 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus CEP63 PF17045.5 EMD65621.1 - 0.11 12.4 16.6 0.062 13.2 11.2 2.6 1 1 2 3 3 3 0 Centrosomal protein of 63 kDa AAA_13 PF13166.6 EMD65621.1 - 0.13 10.9 5.5 0.16 10.6 5.5 1.1 1 0 0 1 1 1 0 AAA domain ABC_tran_CTD PF16326.5 EMD65621.1 - 0.14 12.5 0.2 0.14 12.5 0.2 4.6 3 1 1 4 4 4 0 ABC transporter C-terminal domain OmpH PF03938.14 EMD65621.1 - 0.14 12.5 8.8 0.42 11.0 1.1 2.6 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Fez1 PF06818.15 EMD65621.1 - 0.26 11.7 15.2 0.26 11.7 9.4 2.6 1 1 1 2 2 2 0 Fez1 DivIC PF04977.15 EMD65621.1 - 0.26 11.1 11.8 2.6 7.9 0.5 3.7 3 0 0 3 3 3 0 Septum formation initiator FlaC_arch PF05377.11 EMD65621.1 - 0.28 11.6 2.0 35 4.9 0.0 3.2 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) TACC_C PF05010.14 EMD65621.1 - 0.39 10.5 8.4 0.31 10.8 1.4 2.9 2 1 0 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal GAS PF13851.6 EMD65621.1 - 0.57 9.5 11.2 3.1 7.1 5.0 2.5 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding Med30 PF11315.8 EMD65621.1 - 0.63 10.2 4.5 1 9.5 2.2 2.2 1 1 1 2 2 2 0 Mediator complex subunit 30 COG5 PF10392.9 EMD65621.1 - 0.93 9.7 8.4 5 7.3 1.5 2.8 3 1 0 3 3 2 0 Golgi transport complex subunit 5 SlyX PF04102.12 EMD65621.1 - 1.4 9.6 9.9 0.34 11.5 2.8 3.2 2 1 0 2 2 2 0 SlyX Arm-DNA-bind_5 PF17293.2 EMD65621.1 - 1.8 9.1 6.8 3.4 8.2 1.8 2.7 2 2 0 2 2 2 0 Arm DNA-binding domain DUF5082 PF16888.5 EMD65621.1 - 1.8 8.8 6.5 5.7 7.2 0.1 2.7 3 0 0 3 3 2 0 Domain of unknown function (DUF5082) Kre28 PF17097.5 EMD65621.1 - 1.8 7.4 8.0 0.38 9.6 3.4 2.1 2 1 1 3 3 3 0 Spindle pole body component ADIP PF11559.8 EMD65621.1 - 2.9 7.9 13.1 1 9.5 4.4 3.2 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding GvpK PF05121.12 EMD65621.1 - 4 7.5 14.4 4.1 7.5 2.0 3.5 2 2 1 3 3 3 0 Gas vesicle protein K DUF16 PF01519.16 EMD65621.1 - 4.1 8.0 7.5 7.7 7.1 0.2 2.8 2 1 0 2 2 2 0 Protein of unknown function DUF16 Atg14 PF10186.9 EMD65621.1 - 4.6 6.2 9.1 4.1 6.4 6.8 2.1 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Seryl_tRNA_N PF02403.22 EMD65621.1 - 5.6 7.2 15.5 1.8e+02 2.4 0.2 3.8 2 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain FAM76 PF16046.5 EMD65621.1 - 6.5 6.0 8.1 10 5.3 0.1 2.1 1 1 0 2 2 2 0 FAM76 protein ATG16 PF08614.11 EMD65621.1 - 6.8 6.9 27.6 0.31 11.2 3.6 2.9 2 1 0 2 2 2 0 Autophagy protein 16 (ATG16) Cob_adeno_trans PF01923.18 EMD65621.1 - 9.7 6.3 11.8 4.3 7.4 0.5 3.0 2 1 1 3 3 3 0 Cobalamin adenosyltransferase Ion_trans_2 PF07885.16 EMD65623.1 - 4.3e-25 87.5 29.8 2e-14 53.3 6.9 3.5 3 0 0 3 3 3 2 Ion channel SieB PF14163.6 EMD65623.1 - 0.52 9.8 2.0 2.3 7.7 0.1 2.8 1 1 1 2 2 2 0 Super-infection exclusion protein B Deltameth_res PF16020.5 EMD65623.1 - 3.1 7.7 5.9 0.8 9.6 1.3 2.4 3 0 0 3 3 3 0 Deltamethrin resistance CPP1-like PF11833.8 EMD65623.1 - 3.3 7.3 11.9 2.7 7.6 3.7 3.2 3 0 0 3 3 3 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like DEAD PF00270.29 EMD65624.1 - 1.3e-44 152.1 0.0 3.4e-44 150.7 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EMD65624.1 - 1.8e-29 102.3 0.0 2.3e-27 95.5 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Abhydrolase_3 PF07859.13 EMD65624.1 - 3.6e-23 82.5 0.0 7.4e-22 78.3 0.0 2.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 EMD65624.1 - 5.3e-05 22.3 0.0 9.3e-05 21.5 0.0 1.3 1 0 0 1 1 1 1 Carboxylesterase family ResIII PF04851.15 EMD65624.1 - 0.0022 18.0 0.0 0.0048 16.9 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit UTP25 PF06862.12 EMD65624.1 - 0.053 12.3 0.0 0.67 8.7 0.0 2.4 2 1 0 2 2 2 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 DUF2457 PF10446.9 EMD65626.1 - 1.7e-150 502.3 35.4 1.7e-150 502.3 35.4 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF2457) TFIIA PF03153.13 EMD65626.1 - 0.00083 19.5 10.5 0.002 18.2 10.5 1.8 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Nop14 PF04147.12 EMD65626.1 - 0.98 7.6 20.4 1.9 6.6 20.4 1.5 1 0 0 1 1 1 0 Nop14-like family DNA_pol_D_N PF18018.1 EMD65627.1 - 0.094 12.8 0.0 0.13 12.4 0.0 1.2 1 0 0 1 1 1 0 DNA polymerase delta subunit OB-fold domain FUSC_2 PF13515.6 EMD65627.1 - 0.49 10.5 4.3 0.36 10.9 0.9 2.0 2 0 0 2 2 2 0 Fusaric acid resistance protein-like HSP90 PF00183.18 EMD65629.1 - 5.1e-213 708.7 25.4 7.7e-213 708.1 25.4 1.2 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.26 EMD65629.1 - 3.1e-15 56.6 0.1 5.8e-15 55.8 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 EMD65629.1 - 1.9e-10 40.7 0.2 5.9e-10 39.1 0.2 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF1676 PF07898.13 EMD65629.1 - 0.69 9.9 3.0 2.2 8.3 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1676) Glyco_hydro_88 PF07470.13 EMD65630.1 - 1.5e-87 293.9 0.8 1.7e-87 293.7 0.8 1.0 1 0 0 1 1 1 1 Glycosyl Hydrolase Family 88 MFS_1 PF07690.16 EMD65631.1 - 1.2e-31 110.0 24.1 1.5e-31 109.6 24.1 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Flavin_Reduct PF01613.18 EMD65632.1 - 7.6e-16 58.5 0.0 1e-15 58.1 0.0 1.1 1 0 0 1 1 1 1 Flavin reductase like domain adh_short PF00106.25 EMD65633.1 - 4.2e-13 49.2 0.0 1e-12 48.0 0.0 1.6 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD65633.1 - 1.3e-06 28.2 0.2 8.3e-06 25.5 0.2 2.2 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 EMD65633.1 - 0.0011 18.5 0.0 0.0021 17.5 0.0 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF3437 PF11919.8 EMD65633.1 - 0.099 12.6 0.0 0.21 11.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3437) KR PF08659.10 EMD65633.1 - 0.18 11.7 7.9 71 3.2 7.9 3.5 1 1 0 1 1 1 0 KR domain FAF PF11250.8 EMD65634.1 - 0.58 10.5 0.0 0.58 10.5 0.0 2.4 2 0 0 2 2 2 0 Fantastic Four meristem regulator zf-ANAPC11 PF12861.7 EMD65635.1 - 6.6e-43 144.7 8.7 7.8e-43 144.5 8.7 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 EMD65635.1 - 5e-22 77.9 11.4 7.4e-22 77.4 11.4 1.3 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 EMD65635.1 - 1.7e-08 34.6 14.2 9.7e-08 32.2 14.2 2.0 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 EMD65635.1 - 1.5e-05 24.7 11.7 3.8e-05 23.5 11.7 1.8 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EMD65635.1 - 8.2e-05 22.6 12.5 0.00077 19.4 7.8 2.3 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EMD65635.1 - 0.00043 20.1 7.7 0.00043 20.1 7.7 2.6 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EMD65635.1 - 0.0038 17.1 11.1 0.38 10.7 11.4 2.3 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EMD65635.1 - 0.0044 17.0 13.5 0.024 14.6 13.5 2.1 1 1 0 1 1 1 1 zinc-RING finger domain Zn_ribbon_17 PF17120.5 EMD65635.1 - 0.0072 15.9 6.1 0.0072 15.9 6.1 1.9 1 1 0 2 2 2 1 Zinc-ribbon, C4HC2 type zf-RING_4 PF14570.6 EMD65635.1 - 0.011 15.5 10.4 0.49 10.2 7.7 2.6 2 1 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.6 EMD65635.1 - 0.015 15.4 4.6 0.015 15.4 4.6 2.2 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING FANCL_C PF11793.8 EMD65635.1 - 0.017 15.3 14.0 0.13 12.4 14.0 2.2 1 1 0 1 1 1 0 FANCL C-terminal domain Rad50_zn_hook PF04423.14 EMD65635.1 - 0.019 14.8 0.1 0.019 14.8 0.1 1.6 2 0 0 2 2 2 0 Rad50 zinc hook motif zf-Nse PF11789.8 EMD65635.1 - 0.029 14.2 6.3 0.072 12.9 6.2 1.8 1 1 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RING-like PF08746.11 EMD65635.1 - 0.03 14.6 7.0 0.03 14.6 7.0 1.8 2 1 0 2 2 1 0 RING-like domain zf-HIT PF04438.16 EMD65635.1 - 0.066 13.1 9.2 0.081 12.8 3.9 2.3 2 0 0 2 2 2 0 HIT zinc finger zf-RING_11 PF17123.5 EMD65635.1 - 0.12 12.2 12.7 0.48 10.2 10.2 2.8 2 1 0 2 2 2 0 RING-like zinc finger zf-RING_6 PF14835.6 EMD65635.1 - 0.16 11.9 4.8 0.21 11.5 4.1 1.6 1 1 0 1 1 1 0 zf-RING of BARD1-type protein RecR PF02132.15 EMD65635.1 - 0.91 9.1 8.9 0.61 9.7 0.3 3.1 3 0 0 3 3 3 0 RecR protein RINGv PF12906.7 EMD65635.1 - 2.9 8.1 13.1 11 6.3 12.5 2.1 1 1 0 1 1 1 0 RING-variant domain DZR PF12773.7 EMD65635.1 - 3.6 7.7 12.3 5.9 7.0 3.7 2.4 1 1 1 2 2 2 0 Double zinc ribbon Rhodanese PF00581.20 EMD65636.1 - 7.8e-16 58.5 0.0 1.3e-09 38.6 0.0 2.3 2 0 0 2 2 2 2 Rhodanese-like domain RRN9 PF10680.9 EMD65637.1 - 2.2e-17 63.1 2.3 2.2e-17 63.1 2.3 2.3 2 0 0 2 2 2 1 RNA polymerase I specific transcription initiation factor Metallophos PF00149.28 EMD65638.1 - 5.1e-11 43.5 0.1 2e-10 41.5 0.1 2.0 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EMD65638.1 - 1.4e-09 38.4 0.0 6.9e-09 36.1 0.0 2.0 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain COesterase PF00135.28 EMD65639.1 - 2.2e-90 304.0 0.0 3e-90 303.5 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EMD65639.1 - 0.00028 20.8 0.2 0.011 15.7 0.1 2.2 2 0 0 2 2 2 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EMD65639.1 - 0.0069 15.9 0.3 0.012 15.1 0.3 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family NIF3 PF01784.18 EMD65641.1 - 1.1e-13 51.4 0.0 1.7e-13 50.8 0.0 1.2 1 0 0 1 1 1 1 NIF3 (NGG1p interacting factor 3) tRNA_SAD PF07973.14 EMD65642.1 - 4.7e-09 36.2 0.2 1.3e-08 34.8 0.2 1.8 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain tRNA-synt_2c PF01411.19 EMD65642.1 - 0.0071 14.9 0.0 0.012 14.2 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class II (A) Ldh_1_C PF02866.18 EMD65642.1 - 0.069 13.1 0.2 0.14 12.1 0.2 1.4 1 0 0 1 1 1 0 lactate/malate dehydrogenase, alpha/beta C-terminal domain Glyco_hydro_16 PF00722.21 EMD65643.1 - 3.8e-06 26.5 0.0 9.4e-06 25.2 0.0 1.6 2 0 0 2 2 2 1 Glycosyl hydrolases family 16 Glyco_tranf_2_3 PF13641.6 EMD65644.1 - 1e-22 81.2 0.7 3.7e-22 79.4 0.7 1.8 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 EMD65644.1 - 0.03 14.1 0.0 0.061 13.1 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 EMD65644.1 - 0.033 13.7 0.5 2.7 7.4 0.0 2.6 3 0 0 3 3 3 0 Glycosyl transferase family 21 zf-C2H2 PF00096.26 EMD65647.1 - 4.4e-05 23.7 16.4 1.1 9.9 0.2 5.6 5 0 0 5 5 5 3 Zinc finger, C2H2 type zf-met PF12874.7 EMD65647.1 - 0.057 13.8 1.2 5 7.7 0.5 3.2 2 0 0 2 2 2 0 Zinc-finger of C2H2 type FOXP-CC PF16159.5 EMD65647.1 - 0.11 13.1 2.9 3.2 8.5 0.2 3.3 3 0 0 3 3 3 0 FOXP coiled-coil domain Pox_G9-A16 PF03003.16 EMD65647.1 - 0.12 12.1 0.2 0.22 11.2 0.2 1.4 1 0 0 1 1 1 0 Pox virus entry-fusion-complex G9/A16 zf-C2H2_jaz PF12171.8 EMD65647.1 - 0.32 11.3 4.8 11 6.5 0.3 3.5 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding PBP1_TM PF14812.6 EMD65647.1 - 0.72 10.3 3.9 1.8 9.0 3.9 1.6 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal zf-C2H2_4 PF13894.6 EMD65647.1 - 1.2 10.1 17.8 1.3 10.0 0.1 5.3 5 1 0 5 5 5 0 C2H2-type zinc finger RPN7 PF10602.9 EMD65648.1 - 4.5e-47 160.0 0.7 7.1e-47 159.3 0.7 1.3 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.27 EMD65648.1 - 1.6e-13 51.1 0.6 3.8e-12 46.7 0.1 2.8 3 0 0 3 3 3 1 PCI domain TPR_2 PF07719.17 EMD65648.1 - 0.0048 16.9 2.4 2.9 8.2 0.0 3.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 EMD65648.1 - 0.027 14.7 1.0 0.51 10.7 0.2 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 EMD65648.1 - 0.043 13.7 1.3 5.8 6.9 0.2 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_21 PF09976.9 EMD65648.1 - 0.13 11.9 1.0 0.74 9.5 0.0 2.5 2 1 1 3 3 3 0 Tetratricopeptide repeat-like domain Zn_clus PF00172.18 EMD65649.1 - 2.8e-07 30.5 13.3 5.3e-07 29.7 13.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TFIIA PF03153.13 EMD65649.1 - 0.0005 20.2 18.1 0.0005 20.2 18.1 3.5 2 1 1 3 3 3 1 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 EMD65649.1 - 0.0075 15.9 22.5 0.0075 15.9 22.5 6.3 2 1 0 3 3 3 1 Spt20 family DUF2828 PF11443.8 EMD65650.1 - 1.5e-239 796.4 0.1 3e-239 795.4 0.1 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF2828) FAST_2 PF08368.12 EMD65651.1 - 0.17 12.7 0.0 0.22 12.3 0.0 1.3 1 0 0 1 1 1 0 FAST kinase-like protein, subdomain 2 Glyco_transf_34 PF05637.12 EMD65652.1 - 6.6e-38 130.8 0.0 4.4e-37 128.1 0.0 2.0 1 1 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family PAN_4 PF14295.6 EMD65653.1 - 0.0038 17.1 1.2 0.0086 16.0 1.2 1.5 1 0 0 1 1 1 1 PAN domain PAN_3 PF08277.12 EMD65653.1 - 0.01 15.6 1.4 0.024 14.4 1.4 1.6 1 0 0 1 1 1 0 PAN-like domain PAN_2 PF08276.11 EMD65653.1 - 0.016 15.3 0.7 0.047 13.8 0.7 1.8 1 0 0 1 1 1 0 PAN-like domain Med13_C PF06333.12 EMD65653.1 - 0.43 9.8 11.2 0.78 9.0 11.2 1.4 1 0 0 1 1 1 0 Mediator complex subunit 13 C-terminal domain Methyltransf_25 PF13649.6 EMD65654.1 - 6.7e-08 33.1 0.0 1.3e-07 32.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMD65654.1 - 2.7e-05 24.8 0.0 4.5e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMD65654.1 - 0.00025 21.6 0.0 0.00047 20.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMD65654.1 - 0.00058 19.7 0.0 0.00086 19.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EMD65654.1 - 0.003 16.9 0.0 0.0042 16.4 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Mannosyl_trans PF05007.13 EMD65656.1 - 8.3e-78 261.8 17.5 1.3e-77 261.2 17.5 1.3 1 0 0 1 1 1 1 Mannosyltransferase (PIG-M) PIG-U PF06728.13 EMD65656.1 - 1.4e-13 50.7 4.9 1.4e-13 50.7 4.9 1.9 2 1 0 2 2 2 1 GPI transamidase subunit PIG-U PEN-2 PF10251.9 EMD65656.1 - 3.5 8.1 13.0 0.25 11.8 0.8 3.6 2 1 0 3 3 3 0 Presenilin enhancer-2 subunit of gamma secretase Translin PF01997.16 EMD65657.1 - 5.2e-69 232.3 0.0 6.2e-69 232.1 0.0 1.1 1 0 0 1 1 1 1 Translin family PIN_4 PF13638.6 EMD65658.1 - 2.3e-05 24.7 0.0 0.00027 21.2 0.0 2.2 2 0 0 2 2 2 1 PIN domain ABC_membrane PF00664.23 EMD65660.1 - 4.2e-84 282.5 32.0 1.3e-43 149.6 9.2 2.3 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EMD65660.1 - 5.8e-59 198.5 0.0 5.8e-28 98.1 0.0 2.4 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EMD65660.1 - 1.5e-13 50.7 1.3 0.00046 19.7 0.0 4.3 4 0 0 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 EMD65660.1 - 5.2e-09 36.5 0.4 0.00049 20.4 0.0 3.5 2 2 0 2 2 2 2 AAA domain AAA_29 PF13555.6 EMD65660.1 - 7.6e-08 32.0 1.5 0.014 15.1 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 EMD65660.1 - 8.7e-08 32.7 0.6 0.0022 18.4 0.0 3.2 3 0 0 3 3 2 2 AAA ATPase domain AAA_25 PF13481.6 EMD65660.1 - 5e-07 29.5 0.4 0.048 13.2 0.0 3.5 3 0 0 3 3 3 2 AAA domain AAA_21 PF13304.6 EMD65660.1 - 1e-06 28.8 1.2 0.93 9.2 0.0 4.5 5 0 0 5 5 4 1 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 EMD65660.1 - 4.2e-06 26.8 0.1 0.15 12.0 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase AAA_18 PF13238.6 EMD65660.1 - 0.00015 22.3 0.0 0.45 11.1 0.0 2.7 2 0 0 2 2 2 2 AAA domain DUF87 PF01935.17 EMD65660.1 - 0.00016 21.8 1.0 0.077 13.1 0.1 2.8 2 0 0 2 2 2 1 Helicase HerA, central domain ABC_ATPase PF09818.9 EMD65660.1 - 0.00039 19.4 0.9 0.014 14.2 0.1 3.1 3 0 0 3 3 3 1 Predicted ATPase of the ABC class AAA_15 PF13175.6 EMD65660.1 - 0.00054 19.8 0.2 0.76 9.4 0.0 2.3 2 0 0 2 2 2 2 AAA ATPase domain AAA_33 PF13671.6 EMD65660.1 - 0.00056 20.1 0.4 1.1 9.4 0.0 2.6 2 0 0 2 2 2 2 AAA domain DUF3987 PF13148.6 EMD65660.1 - 0.0013 17.8 0.0 0.49 9.3 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF3987) CobA_CobO_BtuR PF02572.15 EMD65660.1 - 0.0048 17.2 0.2 0.026 14.8 0.4 2.0 2 0 0 2 2 2 1 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP NACHT PF05729.12 EMD65660.1 - 0.0051 16.7 0.5 4 7.3 0.1 3.1 4 0 0 4 4 2 1 NACHT domain G-alpha PF00503.20 EMD65660.1 - 0.0091 15.2 0.0 5.9 5.9 0.0 2.8 2 1 0 2 2 2 0 G-protein alpha subunit AAA_5 PF07728.14 EMD65660.1 - 0.0093 16.0 0.1 7.1 6.6 0.0 2.9 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 EMD65660.1 - 0.013 15.2 0.1 13 5.5 0.0 3.2 3 0 0 3 3 3 0 Sigma-54 interaction domain AAA_23 PF13476.6 EMD65660.1 - 0.017 15.6 0.4 3.7 8.0 0.1 2.7 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 EMD65660.1 - 0.019 14.5 0.1 6.8 6.2 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_30 PF13604.6 EMD65660.1 - 0.028 14.1 0.9 23 4.6 0.6 3.6 3 1 0 3 3 2 0 AAA domain RNA_helicase PF00910.22 EMD65660.1 - 0.037 14.4 0.2 13 6.3 0.0 2.6 2 0 0 2 2 2 0 RNA helicase MMR_HSR1 PF01926.23 EMD65660.1 - 0.039 14.0 0.2 13 5.9 0.0 2.7 2 0 0 2 2 2 0 50S ribosome-binding GTPase ATPase PF06745.13 EMD65660.1 - 0.044 13.1 7.7 3.5 6.9 0.2 3.6 3 0 0 3 3 3 0 KaiC AAA_24 PF13479.6 EMD65660.1 - 0.063 13.0 1.3 7.6 6.2 0.1 2.7 2 0 0 2 2 2 0 AAA domain APS_kinase PF01583.20 EMD65660.1 - 0.068 13.1 0.2 16 5.3 0.1 2.5 2 0 0 2 2 2 0 Adenylylsulphate kinase FtsK_SpoIIIE PF01580.18 EMD65660.1 - 0.077 12.3 0.2 5 6.4 0.0 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family FUN14 PF04930.15 EMD65660.1 - 0.079 13.4 0.0 0.24 11.8 0.0 1.8 1 0 0 1 1 1 0 FUN14 family PRK PF00485.18 EMD65660.1 - 0.18 11.5 0.5 2.5 7.8 0.1 2.4 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family DUF2075 PF09848.9 EMD65660.1 - 0.26 10.5 0.7 22 4.2 0.2 3.1 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) CbiA PF01656.23 EMD65660.1 - 0.32 11.1 1.4 25 4.9 0.1 3.0 3 0 0 3 3 3 0 CobQ/CobB/MinD/ParA nucleotide binding domain ATP-synt_ab PF00006.25 EMD65660.1 - 0.52 9.9 3.2 17 5.0 0.0 3.3 3 1 0 3 3 3 0 ATP synthase alpha/beta family, nucleotide-binding domain Polysacc_synt_4 PF04669.13 EMD65661.1 - 1.2e-23 83.7 1.3 5.1e-22 78.4 1.3 2.0 1 1 0 1 1 1 1 Polysaccharide biosynthesis DUF512 PF04459.12 EMD65661.1 - 0.014 14.7 0.3 0.015 14.5 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF512) WD40 PF00400.32 EMD65662.1 - 1.3e-12 48.0 19.0 0.0027 18.5 0.0 9.6 9 0 0 9 9 9 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD65662.1 - 2.1e-05 24.7 0.2 2.7 8.3 0.0 5.1 4 1 0 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain BRCT PF00533.26 EMD65663.1 - 5.3e-06 26.7 0.0 1e-05 25.8 0.0 1.5 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 EMD65663.1 - 3.8e-05 23.6 0.0 6.9e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 twin BRCT domain BRCT_2 PF16589.5 EMD65663.1 - 0.00019 21.8 0.0 0.00034 21.0 0.0 1.5 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain FSH1 PF03959.13 EMD65664.1 - 1.6e-63 214.2 0.0 2e-63 213.9 0.0 1.1 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Hydrolase_4 PF12146.8 EMD65664.1 - 0.0013 18.0 0.0 0.0032 16.8 0.0 1.6 1 0 0 1 1 1 1 Serine aminopeptidase, S33 BAAT_C PF08840.11 EMD65664.1 - 0.067 13.1 0.1 0.75 9.7 0.1 2.1 1 1 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal DLH PF01738.18 EMD65664.1 - 0.17 11.4 0.0 0.61 9.6 0.0 1.8 2 0 0 2 2 2 0 Dienelactone hydrolase family PCI PF01399.27 EMD65665.1 - 9.7e-21 74.3 0.1 3.9e-20 72.3 0.0 2.0 2 0 0 2 2 2 1 PCI domain RPN5_C PF18098.1 EMD65665.1 - 1.5e-16 60.2 1.7 4.5e-16 58.7 1.7 1.9 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN5 C-terminal domain PMC2NT PF08066.12 EMD65665.1 - 0.062 14.0 0.1 0.3 11.8 0.1 2.2 1 0 0 1 1 1 0 PMC2NT (NUC016) domain Pkinase PF00069.25 EMD65666.1 - 2.7e-19 69.6 0.1 2.6e-11 43.4 0.1 3.3 1 1 2 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 EMD65666.1 - 0.00066 19.0 0.1 0.0012 18.1 0.1 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EMD65666.1 - 0.18 11.2 0.9 1.1 8.5 0.0 2.3 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_Tyr PF07714.17 EMD65667.1 - 0.0013 18.0 0.0 0.0088 15.3 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMD65667.1 - 0.0072 15.7 0.0 0.031 13.6 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain IL23 PF16649.5 EMD65667.1 - 0.07 13.2 0.0 0.19 11.8 0.0 1.6 2 0 0 2 2 2 0 Interleukin 23 subunit alpha Reticulon PF02453.17 EMD65668.1 - 2.6e-14 53.5 0.1 4.2e-14 52.8 0.1 1.3 1 0 0 1 1 1 1 Reticulon PHO4 PF01384.20 EMD65669.1 - 1.8e-110 369.2 9.9 2.1e-110 369.0 9.9 1.0 1 0 0 1 1 1 1 Phosphate transporter family DUF4271 PF14093.6 EMD65669.1 - 0.045 13.7 2.8 1.7 8.5 1.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4271) Caveolin PF01146.17 EMD65669.1 - 0.4 10.6 3.1 0.37 10.7 0.7 2.2 2 0 0 2 2 2 0 Caveolin Mito_carr PF00153.27 EMD65670.1 - 1.3e-71 236.5 1.0 2.5e-25 88.2 0.0 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_7 PF13499.6 EMD65670.1 - 2e-16 60.2 3.1 2.6e-07 31.0 0.4 3.1 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.32 EMD65670.1 - 8.3e-15 53.2 3.3 0.00031 20.1 0.1 4.8 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 EMD65670.1 - 2.2e-14 52.0 1.3 0.00024 20.8 0.0 5.8 6 0 0 6 6 6 2 EF-hand domain EF-hand_8 PF13833.6 EMD65670.1 - 1.2e-10 41.1 0.4 0.00053 19.8 0.0 4.9 4 0 0 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.6 EMD65670.1 - 3.1e-08 32.7 5.2 0.0054 16.2 0.1 4.5 4 0 0 4 4 4 2 EF hand Caleosin PF05042.13 EMD65670.1 - 0.013 15.4 0.3 0.91 9.4 0.0 2.4 2 0 0 2 2 2 0 Caleosin related protein Serine_protease PF18405.1 EMD65670.1 - 0.067 12.3 1.4 4.1 6.5 0.1 3.1 2 1 0 3 3 3 0 Gammaproteobacterial serine protease Dockerin_1 PF00404.18 EMD65670.1 - 0.098 12.9 0.0 6.2 7.1 0.0 3.0 3 0 0 3 3 3 0 Dockerin type I domain zf-C2H2 PF00096.26 EMD65671.1 - 3.3e-07 30.4 12.1 0.006 17.0 2.0 3.6 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMD65671.1 - 0.00029 21.1 9.9 0.56 10.7 0.7 3.8 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMD65671.1 - 0.029 15.2 10.9 0.13 13.2 1.7 3.7 3 0 0 3 3 3 0 C2H2-type zinc finger zf-Di19 PF05605.12 EMD65671.1 - 0.082 13.2 7.0 0.37 11.1 1.1 2.4 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding PT PF04886.12 EMD65672.1 - 0.0015 18.1 10.6 0.0045 16.5 4.9 2.9 1 1 1 2 2 2 2 PT repeat Poxvirus_B22R_C PF13168.6 EMD65672.1 - 0.017 14.6 0.0 0.028 13.9 0.0 1.3 1 0 0 1 1 1 0 Poxvirus B22R protein C-terminal MFS_1 PF07690.16 EMD65673.1 - 1.2e-44 152.7 45.3 1.5e-44 152.4 43.7 1.9 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EMD65673.1 - 6e-11 41.9 5.3 6e-11 41.9 5.3 2.6 2 1 0 2 2 2 1 Sugar (and other) transporter SMC_N PF02463.19 EMD65674.1 - 8.3e-60 201.9 8.6 2.6e-58 197.0 8.6 2.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EMD65674.1 - 3.2e-24 85.5 0.0 1.1e-23 83.7 0.0 2.0 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 EMD65674.1 - 2.4e-09 37.4 0.1 1.8e-05 24.7 0.0 4.7 5 2 0 5 5 5 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EMD65674.1 - 3.2e-08 33.2 0.0 6.4e-08 32.2 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.6 EMD65674.1 - 0.00042 20.2 26.3 0.00042 20.2 26.3 4.7 2 2 1 3 3 3 1 AAA ATPase domain SbcCD_C PF13558.6 EMD65674.1 - 0.0018 18.5 0.0 0.092 13.0 0.0 3.1 2 0 0 2 2 2 1 Putative exonuclease SbcCD, C subunit ADIP PF11559.8 EMD65674.1 - 0.003 17.7 10.4 0.003 17.7 10.4 9.0 5 2 4 9 9 9 3 Afadin- and alpha -actinin-Binding HIP1_clath_bdg PF16515.5 EMD65674.1 - 0.0041 17.7 6.9 0.0041 17.7 6.9 10.9 4 3 6 12 12 12 1 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF2939 PF11159.8 EMD65674.1 - 0.039 14.4 2.4 19 5.7 0.1 4.4 3 1 0 3 3 3 0 Protein of unknown function (DUF2939) DUF2838 PF10998.8 EMD65675.1 - 1.2e-43 147.8 10.6 1.2e-43 147.8 10.6 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF2838) Fzo_mitofusin PF04799.13 EMD65675.1 - 0.032 13.8 0.6 0.06 12.9 0.6 1.4 1 0 0 1 1 1 0 fzo-like conserved region Exonuc_VII_L PF02601.15 EMD65675.1 - 0.059 12.9 1.8 0.09 12.3 1.8 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit NAD_binding_8 PF13450.6 EMD65676.1 - 3.7e-13 49.5 0.2 1.1e-12 48.0 0.2 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EMD65676.1 - 5.5e-08 32.8 0.1 3.4e-06 26.9 0.1 2.3 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EMD65676.1 - 9e-08 31.7 0.1 6.3e-05 22.3 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 EMD65676.1 - 1.7e-06 27.6 0.2 0.035 13.4 0.0 3.4 3 0 0 3 3 3 2 Flavin containing amine oxidoreductase Pyr_redox PF00070.27 EMD65676.1 - 2.1e-05 25.0 0.3 0.24 12.0 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EMD65676.1 - 2.2e-05 23.7 0.0 3.7e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain NAD_binding_9 PF13454.6 EMD65676.1 - 7.7e-05 22.7 0.1 0.002 18.2 0.0 2.7 3 0 0 3 3 3 1 FAD-NAD(P)-binding HI0933_like PF03486.14 EMD65676.1 - 9.9e-05 21.2 0.1 0.0034 16.2 0.0 2.1 2 0 0 2 2 2 1 HI0933-like protein Thi4 PF01946.17 EMD65676.1 - 0.0029 16.9 0.0 0.0056 15.9 0.0 1.4 1 0 0 1 1 1 1 Thi4 family Lycopene_cycl PF05834.12 EMD65676.1 - 0.0034 16.5 0.0 0.0055 15.8 0.0 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein FAD_binding_3 PF01494.19 EMD65676.1 - 0.02 14.2 0.0 0.14 11.3 0.0 2.1 2 0 0 2 2 2 0 FAD binding domain RE_Bsp6I PF09504.10 EMD65676.1 - 0.04 13.5 0.1 0.08 12.5 0.1 1.4 1 0 0 1 1 1 0 Bsp6I restriction endonuclease Pyr_redox_3 PF13738.6 EMD65676.1 - 0.055 12.7 0.0 0.4 9.9 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.16 EMD65676.1 - 0.089 12.4 0.1 0.63 9.7 0.0 2.1 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA Shikimate_DH PF01488.20 EMD65676.1 - 0.16 12.1 0.0 0.3 11.2 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Peptidase_C50 PF03568.17 EMD65677.1 - 5.4e-150 499.9 0.4 3.2e-149 497.4 0.0 2.4 2 0 0 2 2 2 1 Peptidase family C50 Fungal_trans PF04082.18 EMD65677.1 - 4.4e-22 78.4 1.2 9.6e-22 77.3 1.2 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain CHAT PF12770.7 EMD65677.1 - 0.00061 19.3 0.1 0.013 14.9 0.0 3.1 2 1 0 2 2 2 1 CHAT domain Zn_clus PF00172.18 EMD65677.1 - 0.0034 17.5 11.1 0.007 16.5 11.1 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TPR_8 PF13181.6 EMD65677.1 - 0.14 12.4 4.7 0.43 10.9 0.0 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 EMD65677.1 - 0.49 11.0 4.1 1.7 9.2 0.2 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 EMD65677.1 - 0.69 10.2 10.9 17 5.8 0.0 6.3 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_MalT PF17874.1 EMD65677.1 - 2.1 7.7 10.1 0.51 9.7 1.1 4.0 4 1 0 4 4 4 0 MalT-like TPR region TPR_14 PF13428.6 EMD65677.1 - 2.5 9.2 8.3 1.3e+02 3.8 0.0 6.6 6 0 0 6 6 6 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EMD65677.1 - 3.5 7.9 5.2 5.3 7.4 0.4 3.4 3 0 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 Git3 PF11710.8 EMD65678.1 - 2.5e-22 79.7 18.4 3.9e-22 79.0 18.4 1.3 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 GPR_Gpa2_C PF11970.8 EMD65678.1 - 7.4e-06 26.0 0.2 7.4e-06 26.0 0.2 2.8 3 0 0 3 3 3 1 G protein-coupled glucose receptor regulating Gpa2 C-term zf-C2H2_4 PF13894.6 EMD65681.1 - 0.046 14.6 7.7 0.15 13.0 0.6 2.4 2 0 0 2 2 2 0 C2H2-type zinc finger RSN1_7TM PF02714.15 EMD65682.1 - 2.3e-77 260.0 17.3 2.3e-77 260.0 17.3 2.1 2 0 0 2 2 2 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 EMD65682.1 - 4.8e-40 136.9 1.6 1.1e-39 135.7 1.6 1.7 1 0 0 1 1 1 1 Late exocytosis, associated with Golgi transport PHM7_ext PF12621.8 EMD65682.1 - 2.3e-25 88.6 0.2 2.3e-25 88.6 0.2 2.4 3 0 0 3 3 3 1 Extracellular tail, of 10TM putative phosphate transporter PHM7_cyt PF14703.6 EMD65682.1 - 1.1e-20 74.6 0.5 2.4e-20 73.5 0.1 1.9 2 0 0 2 2 2 1 Cytosolic domain of 10TM putative phosphate transporter GMC_oxred_N PF00732.19 EMD65683.1 - 1.2e-61 208.7 0.0 1.5e-61 208.4 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EMD65683.1 - 8.1e-33 114.0 0.0 1.6e-32 113.0 0.0 1.6 1 0 0 1 1 1 1 GMC oxidoreductase DAO PF01266.24 EMD65683.1 - 0.002 17.8 0.4 0.0051 16.4 0.4 1.9 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EMD65683.1 - 0.0026 16.9 1.1 0.0091 15.1 0.7 1.9 2 0 0 2 2 2 1 FAD binding domain Lycopene_cycl PF05834.12 EMD65683.1 - 0.0035 16.4 0.3 0.0056 15.8 0.3 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein NAD_binding_8 PF13450.6 EMD65683.1 - 0.0037 17.5 0.3 0.016 15.4 0.3 2.1 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EMD65683.1 - 0.011 15.0 0.2 0.026 13.8 0.1 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EMD65683.1 - 0.016 14.4 0.1 0.029 13.6 0.1 1.3 1 0 0 1 1 1 0 Thi4 family Pyr_redox_3 PF13738.6 EMD65683.1 - 0.031 13.5 0.9 0.69 9.1 0.6 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.18 EMD65683.1 - 0.063 13.5 0.1 0.18 12.0 0.1 1.8 1 0 0 1 1 1 0 TrkA-N domain HI0933_like PF03486.14 EMD65683.1 - 0.089 11.5 0.2 0.47 9.1 0.1 1.9 2 0 0 2 2 2 0 HI0933-like protein WD40 PF00400.32 EMD65684.1 - 4.6e-09 36.7 10.8 0.0001 23.0 0.4 4.4 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD65684.1 - 0.001 19.4 0.0 1.2 9.4 0.0 3.6 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 EMD65684.1 - 0.0073 15.9 0.1 0.16 11.6 0.0 2.5 2 0 0 2 2 2 1 PQQ-like domain Gryzun-like PF12742.7 EMD65684.1 - 0.0086 16.1 0.0 0.019 15.0 0.0 1.5 1 0 0 1 1 1 1 Gryzun, putative Golgi trafficking Nbas_N PF15492.6 EMD65684.1 - 0.03 13.7 0.0 0.14 11.4 0.0 2.0 2 0 0 2 2 2 0 Neuroblastoma-amplified sequence, N terminal Peptidase_C65 PF10275.9 EMD65685.1 - 1.5e-72 244.0 0.0 1.9e-72 243.7 0.0 1.1 1 0 0 1 1 1 1 Peptidase C65 Otubain PCI PF01399.27 EMD65688.1 - 1.6e-20 73.5 1.6 2.1e-20 73.2 0.5 1.8 2 0 0 2 2 2 1 PCI domain TPR_7 PF13176.6 EMD65688.1 - 0.011 15.8 1.4 1.8 8.8 0.1 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 EMD65688.1 - 0.26 11.2 1.9 1.8 8.6 0.4 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat Ras PF00071.22 EMD65689.1 - 1.1e-54 184.4 0.0 1.3e-54 184.2 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMD65689.1 - 1.6e-21 76.7 0.0 2.6e-21 76.0 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMD65689.1 - 3.6e-09 36.3 0.0 5.5e-09 35.7 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EMD65689.1 - 0.0004 19.9 0.0 0.00071 19.1 0.0 1.4 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 EMD65689.1 - 0.0012 18.2 0.0 0.0015 17.9 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.20 EMD65689.1 - 0.0075 15.5 0.0 0.049 12.8 0.0 1.6 1 1 1 2 2 2 1 G-protein alpha subunit MMR_HSR1 PF01926.23 EMD65689.1 - 0.028 14.5 0.0 0.049 13.7 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase ABC_tran PF00005.27 EMD65689.1 - 0.084 13.4 0.0 0.15 12.6 0.0 1.4 1 1 0 1 1 1 0 ABC transporter RsgA_GTPase PF03193.16 EMD65689.1 - 0.11 12.4 0.0 13 5.7 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase Mac PF12464.8 EMD65690.1 - 1e-13 51.3 0.0 2e-13 50.3 0.0 1.5 1 0 0 1 1 1 1 Maltose acetyltransferase Hexapep PF00132.24 EMD65690.1 - 1e-09 37.7 4.8 3.9e-07 29.5 2.5 2.5 2 0 0 2 2 2 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 EMD65690.1 - 9.8e-09 34.8 5.0 5.2e-05 22.9 2.2 2.4 2 0 0 2 2 2 2 Hexapeptide repeat of succinyl-transferase Ribosomal_S27e PF01667.17 EMD65691.1 - 1e-28 98.8 6.9 1.3e-28 98.5 6.9 1.1 1 0 0 1 1 1 1 Ribosomal protein S27 zf-CSL PF05207.13 EMD65691.1 - 0.2 11.4 2.4 0.43 10.3 2.4 1.6 1 1 0 1 1 1 0 CSL zinc finger zf-C2HC5 PF06221.13 EMD65691.1 - 0.87 9.6 7.0 4.4 7.4 4.5 2.3 2 1 0 2 2 2 0 Putative zinc finger motif, C2HC5-type DeoC PF01791.9 EMD65692.1 - 5.4e-15 55.6 1.1 1.9e-07 31.0 0.1 2.2 1 1 1 2 2 2 2 DeoC/LacD family aldolase His_biosynth PF00977.21 EMD65692.1 - 0.019 14.5 0.1 0.046 13.2 0.0 1.6 2 0 0 2 2 2 0 Histidine biosynthesis protein Bd3614_N PF14442.6 EMD65692.1 - 0.02 15.2 0.0 0.094 13.0 0.0 2.1 2 0 0 2 2 2 0 Bd3614-like deaminase N-terminal S4 PF01479.25 EMD65693.1 - 2.3e-12 46.4 0.6 2.3e-12 46.4 0.6 2.2 2 0 0 2 2 2 1 S4 domain Ribosomal_S4 PF00163.19 EMD65693.1 - 1.2e-05 26.1 0.1 2.3e-05 25.2 0.1 1.5 1 0 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain Uds1 PF15456.6 EMD65693.1 - 0.04 14.1 0.2 4 7.6 0.0 2.2 2 0 0 2 2 2 0 Up-regulated During Septation Ribosomal_L21e PF01157.18 EMD65694.1 - 7.9e-47 157.3 4.3 1.3e-46 156.6 4.3 1.3 1 0 0 1 1 1 1 Ribosomal protein L21e PAS_9 PF13426.7 EMD65695.1 - 1.7e-11 44.3 0.0 5.9e-10 39.3 0.0 2.4 2 0 0 2 2 2 1 PAS domain Ribosomal_L18 PF17135.4 EMD65695.1 - 0.011 15.2 0.0 0.019 14.4 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein 60S L18 and 50S L18e PAS PF00989.25 EMD65695.1 - 0.031 14.3 0.0 0.1 12.6 0.0 1.9 2 0 0 2 2 2 0 PAS fold Acetyltransf_10 PF13673.7 EMD65696.1 - 2.6e-09 37.1 0.0 4e-09 36.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EMD65696.1 - 1.1e-06 28.9 0.0 1.7e-06 28.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 EMD65696.1 - 2.7e-06 27.3 0.0 4.2e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_7 PF13508.7 EMD65696.1 - 0.00041 20.7 0.0 0.00082 19.7 0.0 1.6 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EMD65696.1 - 0.0063 16.6 0.0 0.01 15.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain MFS_1 PF07690.16 EMD65698.1 - 1.9e-23 83.0 45.3 3.2e-12 46.0 16.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Mem_trans PF03547.18 EMD65699.1 - 0.56 8.5 1.6 0.81 8.0 1.6 1.2 1 0 0 1 1 1 0 Membrane transport protein SNARE PF05739.19 EMD65701.1 - 2.3e-11 43.5 0.1 2.3e-11 43.5 0.1 2.7 3 0 0 3 3 3 1 SNARE domain Syntaxin-5_N PF11416.8 EMD65701.1 - 6.3e-09 34.8 1.4 2.5e-08 32.9 1.4 2.1 1 0 0 1 1 1 1 Syntaxin-5 N-terminal, Sly1p-binding domain Syntaxin PF00804.25 EMD65701.1 - 0.00012 21.8 15.7 0.0002 21.1 0.4 3.4 2 1 1 3 3 3 2 Syntaxin Syntaxin-18_N PF10496.9 EMD65701.1 - 0.0079 16.4 3.5 0.0081 16.4 1.0 2.2 2 0 0 2 2 2 1 SNARE-complex protein Syntaxin-18 N-terminus DUF16 PF01519.16 EMD65701.1 - 0.022 15.3 0.7 0.022 15.3 0.7 2.8 2 1 0 2 2 2 0 Protein of unknown function DUF16 NPV_P10 PF05531.12 EMD65701.1 - 0.041 14.4 4.4 1.4 9.4 1.5 3.5 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Surfac_D-trimer PF09006.11 EMD65701.1 - 0.045 13.6 0.4 0.58 10.1 0.1 2.7 2 0 0 2 2 2 0 Lung surfactant protein D coiled-coil trimerisation SlyX PF04102.12 EMD65701.1 - 0.17 12.5 0.3 0.17 12.5 0.3 3.8 2 1 2 4 4 4 0 SlyX DUF948 PF06103.11 EMD65701.1 - 0.2 11.9 2.3 2.5 8.4 0.0 3.2 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) BLOC1_2 PF10046.9 EMD65701.1 - 0.26 11.6 6.1 9 6.7 0.1 3.6 3 2 1 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF1664 PF07889.12 EMD65701.1 - 0.32 11.0 5.4 2 8.5 0.3 3.4 2 1 2 4 4 4 0 Protein of unknown function (DUF1664) FlaC_arch PF05377.11 EMD65701.1 - 6.2 7.3 5.7 10 6.6 0.4 3.3 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) DUF3829 PF12889.7 EMD65701.1 - 9.6 5.6 8.7 2.7 7.4 0.6 2.7 2 1 0 3 3 3 0 Protein of unknown function (DUF3829) zf-C2H2 PF00096.26 EMD65703.1 - 3.8e-31 105.8 57.1 1.7e-05 25.0 1.1 10.4 10 0 0 10 10 10 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMD65703.1 - 1.5e-22 78.3 52.3 0.0045 17.7 2.5 10.2 10 0 0 10 10 10 8 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EMD65703.1 - 2.6e-11 43.4 55.1 0.00025 21.3 0.7 11.8 12 0 0 12 12 12 2 Zinc-finger double domain zf-met PF12874.7 EMD65703.1 - 5.9e-09 36.0 17.4 0.35 11.3 0.5 7.9 7 0 0 7 7 7 4 Zinc-finger of C2H2 type zf-C2H2_8 PF15909.5 EMD65703.1 - 0.00029 21.1 21.6 0.044 14.1 0.1 5.4 2 1 4 6 6 6 3 C2H2-type zinc ribbon zf-C2H2_3rep PF18868.1 EMD65703.1 - 0.00039 21.1 28.8 0.01 16.5 4.8 5.1 2 2 2 5 5 5 2 Zinc finger C2H2-type, 3 repeats zf-C2H2_11 PF16622.5 EMD65703.1 - 0.0015 18.3 21.5 0.054 13.3 0.1 5.9 6 0 0 6 6 6 2 zinc-finger C2H2-type zf-C2H2_jaz PF12171.8 EMD65703.1 - 0.0039 17.4 31.0 1.6 9.1 0.0 8.5 10 0 0 10 10 9 2 Zinc-finger double-stranded RNA-binding FOXP-CC PF16159.5 EMD65703.1 - 0.017 15.8 37.5 2.8 8.6 0.5 8.5 6 2 3 9 9 9 0 FOXP coiled-coil domain zf-C2H2_6 PF13912.6 EMD65703.1 - 0.024 14.6 0.8 0.024 14.6 0.8 8.1 9 0 0 9 9 9 0 C2H2-type zinc finger zf-AD PF07776.15 EMD65703.1 - 0.081 13.2 1.6 2 8.7 0.1 3.2 3 0 0 3 3 3 0 Zinc-finger associated domain (zf-AD) DUF5501 PF17605.2 EMD65703.1 - 0.15 12.5 0.1 0.53 10.7 0.0 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5501) XPA_N PF01286.18 EMD65703.1 - 0.46 10.6 3.3 0.49 10.5 0.1 2.9 3 0 0 3 3 3 0 XPA protein N-terminal zf_UBZ PF18439.1 EMD65703.1 - 4.5 6.9 16.3 9.1 6.0 0.6 4.8 6 0 0 6 6 6 0 Ubiquitin-Binding Zinc Finger RNA_pol_Rpb6 PF01192.22 EMD65704.1 - 1.5e-15 56.8 0.1 1.5e-15 56.8 0.1 1.7 3 0 0 3 3 3 1 RNA polymerase Rpb6 DUF4549 PF15082.6 EMD65704.1 - 0.078 12.8 0.0 0.089 12.6 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4549) Esterase PF00756.20 EMD65705.1 - 4.3e-55 187.1 0.1 5.3e-55 186.8 0.1 1.0 1 0 0 1 1 1 1 Putative esterase Peptidase_S9 PF00326.21 EMD65705.1 - 1.4e-06 27.9 0.0 2.4e-06 27.2 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 EMD65705.1 - 0.002 17.4 0.0 0.0029 16.9 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Chlorophyllase2 PF12740.7 EMD65705.1 - 0.0034 16.3 0.0 0.0055 15.6 0.0 1.3 1 0 0 1 1 1 1 Chlorophyllase enzyme Esterase_phd PF10503.9 EMD65705.1 - 0.012 15.2 0.0 0.074 12.5 0.0 1.9 1 1 0 1 1 1 0 Esterase PHB depolymerase Lipase_3 PF01764.25 EMD65705.1 - 0.014 15.2 0.0 0.023 14.5 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) PGAP1 PF07819.13 EMD65705.1 - 0.029 14.1 0.0 0.045 13.5 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein AXE1 PF05448.12 EMD65705.1 - 0.054 12.2 0.0 0.082 11.6 0.0 1.3 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) Abhydrolase_2 PF02230.16 EMD65705.1 - 0.055 13.3 0.0 0.085 12.7 0.0 1.3 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase Chlorophyllase PF07224.11 EMD65705.1 - 0.15 11.0 0.0 0.39 9.7 0.0 1.6 2 0 0 2 2 2 0 Chlorophyllase Xpo1 PF08389.12 EMD65706.1 - 1.7e-35 122.3 1.7 8e-34 116.8 0.1 3.9 5 0 0 5 5 5 1 Exportin 1-like protein DRIM PF07539.12 EMD65706.1 - 0.00051 18.5 1.0 0.82 7.9 0.1 3.2 3 1 0 3 3 3 2 Down-regulated in metastasis HEAT PF02985.22 EMD65706.1 - 0.046 14.0 0.1 81 3.9 0.0 4.6 4 0 0 4 4 4 0 HEAT repeat IBN_N PF03810.19 EMD65706.1 - 0.048 13.6 0.2 0.4 10.6 0.1 2.7 1 1 1 2 2 2 0 Importin-beta N-terminal domain ATP_transf PF09830.9 EMD65707.1 - 1.5e-20 73.1 0.1 2.6e-20 72.3 0.1 1.4 1 0 0 1 1 1 1 ATP adenylyltransferase DUF4931 PF16285.5 EMD65707.1 - 0.019 14.3 0.0 0.025 13.9 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4931) Myb_DNA-bind_4 PF13837.6 EMD65708.1 - 0.0015 18.9 0.2 0.0018 18.6 0.2 1.1 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain YbhQ PF11076.8 EMD65708.1 - 0.16 12.0 0.0 0.2 11.7 0.0 1.1 1 0 0 1 1 1 0 Putative inner membrane protein YbhQ DSBA PF01323.20 EMD65709.1 - 1.1e-22 80.7 0.0 1.3e-22 80.5 0.0 1.1 1 0 0 1 1 1 1 DSBA-like thioredoxin domain adh_short PF00106.25 EMD65710.1 - 9.5e-30 103.5 1.5 1.3e-20 73.7 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EMD65710.1 - 1.3e-22 80.5 1.0 2e-20 73.4 1.0 2.1 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD65710.1 - 0.00085 19.3 0.0 0.0013 18.6 0.0 1.3 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 EMD65710.1 - 0.064 12.6 0.0 10 5.4 0.0 2.1 2 0 0 2 2 2 0 Fungal family of unknown function (DUF1776) THF_DHG_CYH_C PF02882.19 EMD65710.1 - 0.075 12.3 0.1 0.13 11.6 0.1 1.4 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Anticodon_1 PF08264.13 EMD65711.1 - 0.029 14.3 0.7 0.051 13.5 0.0 1.7 2 0 0 2 2 2 0 Anticodon-binding domain of tRNA T6SS_VasJ PF16989.5 EMD65712.1 - 0.13 11.7 0.0 0.22 11.0 0.0 1.3 1 0 0 1 1 1 0 Type VI secretion, EvfE, EvfF, ImpA, BimE, VC_A0119, VasJ MA3 PF02847.17 EMD65713.1 - 3.5e-25 88.2 0.0 8e-25 87.0 0.0 1.6 1 0 0 1 1 1 1 MA3 domain MIF4G PF02854.19 EMD65713.1 - 7e-12 45.4 0.4 1.2e-11 44.7 0.4 1.3 1 0 0 1 1 1 1 MIF4G domain DPM2 PF07297.12 EMD65714.1 - 5.2e-34 116.4 3.7 6e-34 116.2 3.7 1.0 1 0 0 1 1 1 1 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) PIG-P PF08510.12 EMD65714.1 - 0.00023 21.1 1.7 0.00026 20.9 1.7 1.1 1 0 0 1 1 1 1 PIG-P TMEM169 PF15052.6 EMD65714.1 - 0.0049 17.0 0.9 0.0054 16.9 0.9 1.0 1 0 0 1 1 1 1 TMEM169 protein family LapA_dom PF06305.11 EMD65714.1 - 0.018 14.8 0.7 0.018 14.8 0.7 1.8 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain Phage_holin_3_6 PF07332.11 EMD65714.1 - 0.023 14.7 1.1 0.025 14.6 1.1 1.1 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III COX14 PF14880.6 EMD65714.1 - 0.042 13.7 5.2 0.19 11.6 0.1 2.2 2 0 0 2 2 2 0 Cytochrome oxidase c assembly DUF4229 PF14012.6 EMD65714.1 - 0.047 13.8 0.3 0.047 13.8 0.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4229) WD40 PF00400.32 EMD65715.1 - 4.7e-18 65.2 8.9 9.4e-06 26.3 0.1 6.5 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD65715.1 - 0.0017 18.6 0.0 0.021 15.1 0.0 2.6 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain DUF971 PF06155.12 EMD65715.1 - 0.064 13.9 0.0 1.2 9.8 0.0 3.0 4 1 0 4 4 4 0 Protein of unknown function (DUF971) Glyco_hydro_18 PF00704.28 EMD65716.1 - 1.4e-13 51.3 0.2 2.4e-13 50.5 0.2 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 MFS_1 PF07690.16 EMD65717.1 - 2e-29 102.7 32.9 2e-29 102.7 32.9 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily Spc7 PF08317.11 EMD65718.1 - 5.1e-113 377.0 11.3 5.1e-113 377.0 11.3 1.9 2 0 0 2 2 2 1 Spc7 kinetochore protein Spc7_N PF15402.6 EMD65718.1 - 3.7e-77 260.5 86.3 3.8e-58 197.6 37.8 5.4 2 1 1 3 3 3 3 N-terminus of kinetochore NMS complex subunit Spc7 Spc7_C2 PF15577.6 EMD65718.1 - 2e-20 72.6 0.1 4.1e-20 71.6 0.1 1.6 1 0 0 1 1 1 1 Spc7_C2 Exonuc_VII_L PF02601.15 EMD65718.1 - 7 6.1 12.1 0.42 10.1 3.6 2.4 2 0 0 2 2 2 0 Exonuclease VII, large subunit tRNA-synt_2 PF00152.20 EMD65722.1 - 3.9e-92 308.7 0.0 5.3e-92 308.2 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA-synt_2b PF00587.25 EMD65722.1 - 0.00073 19.6 0.1 0.0021 18.1 0.0 1.7 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) tRNA-synt_2d PF01409.20 EMD65722.1 - 0.0038 16.8 0.1 0.012 15.1 0.1 1.8 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) LRR_4 PF12799.7 EMD65723.1 - 0.015 15.7 0.9 6.2 7.4 0.0 3.8 3 2 0 3 3 3 0 Leucine Rich repeats (2 copies) Helo_like_N PF17111.5 EMD65724.1 - 0.0053 16.2 0.1 0.0053 16.2 0.1 2.5 2 1 1 3 3 3 1 Fungal N-terminal domain of STAND proteins SseC PF04888.12 EMD65724.1 - 0.1 12.2 0.1 0.1 12.2 0.1 3.2 2 1 2 4 4 4 0 Secretion system effector C (SseC) like family UbiA PF01040.18 EMD65725.1 - 1.6e-60 204.5 15.9 1.6e-60 204.5 15.9 1.3 1 1 0 1 1 1 1 UbiA prenyltransferase family AAA_lid_2 PF17863.1 EMD65725.1 - 0.26 11.2 0.8 1.6 8.6 0.2 2.2 2 0 0 2 2 2 0 AAA lid domain Hydrolase_4 PF12146.8 EMD65726.1 - 3.6e-17 62.4 0.0 7.1e-14 51.6 0.0 2.3 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EMD65726.1 - 6.4e-16 58.8 0.0 1.3e-15 57.8 0.0 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EMD65726.1 - 3.7e-12 47.3 0.3 7e-12 46.4 0.0 1.6 2 0 0 2 2 2 1 Alpha/beta hydrolase family DLH PF01738.18 EMD65726.1 - 0.0065 16.0 0.0 0.5 9.9 0.0 2.6 2 1 0 2 2 2 1 Dienelactone hydrolase family BAAT_C PF08840.11 EMD65726.1 - 0.045 13.7 0.0 0.15 11.9 0.0 1.8 2 0 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_5 PF12695.7 EMD65726.1 - 0.14 11.9 0.0 0.56 10.0 0.0 2.0 2 0 0 2 2 2 0 Alpha/beta hydrolase family RNA_pol_Rpc4 PF05132.14 EMD65726.1 - 0.42 11.0 6.8 1.6 9.1 6.8 1.9 2 0 0 2 2 2 0 RNA polymerase III RPC4 RR_TM4-6 PF06459.12 EMD65726.1 - 1.8 8.3 11.5 2.9 7.6 11.5 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CDC45 PF02724.14 EMD65726.1 - 1.8 6.7 6.9 2.2 6.5 6.9 1.1 1 0 0 1 1 1 0 CDC45-like protein PAP2 PF01569.21 EMD65727.1 - 5.6e-28 97.4 0.2 5.6e-28 97.4 0.2 1.9 2 0 0 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.6 EMD65727.1 - 0.0057 16.4 1.1 0.022 14.5 1.1 2.0 1 1 0 1 1 1 1 PAP2 superfamily Erv26 PF04148.13 EMD65727.1 - 0.15 11.9 0.4 0.26 11.1 0.4 1.3 1 0 0 1 1 1 0 Transmembrane adaptor Erv26 CAP_N PF01213.19 EMD65727.1 - 0.87 9.0 3.4 1.4 8.3 3.4 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal PQ-loop PF04193.14 EMD65728.1 - 2.3e-22 78.5 6.2 2.4e-13 49.6 2.0 2.6 2 0 0 2 2 2 2 PQ loop repeat ERG4_ERG24 PF01222.17 EMD65729.1 - 3.4e-133 444.6 26.4 4.1e-133 444.3 26.4 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family BacA PF02673.18 EMD65729.1 - 0.027 14.2 0.7 0.048 13.4 0.7 1.3 1 0 0 1 1 1 0 Bacitracin resistance protein BacA Acyl-CoA_dh_1 PF00441.24 EMD65730.1 - 5.3e-43 146.8 0.4 8.6e-43 146.1 0.4 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 EMD65730.1 - 4.3e-22 78.1 0.2 7.6e-22 77.3 0.2 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Cyt-b5 PF00173.28 EMD65730.1 - 8e-20 70.8 0.2 1.5e-19 69.9 0.2 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Acyl-CoA_dh_N PF02771.16 EMD65730.1 - 5.2e-18 65.7 0.0 9.9e-18 64.8 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 EMD65730.1 - 2.6e-09 37.5 0.0 5.3e-09 36.5 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain C6 PF01681.17 EMD65730.1 - 0.022 15.3 0.0 0.16 12.5 0.0 2.2 1 1 1 2 2 2 0 C6 domain 2OG-FeII_Oxy PF03171.20 EMD65731.1 - 2e-14 53.9 0.1 3.9e-14 53.0 0.1 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 EMD65731.1 - 1.6e-10 41.7 0.0 2.7e-10 41.0 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal TFR_dimer PF04253.15 EMD65732.1 - 1.9e-23 82.8 0.0 3.1e-23 82.2 0.0 1.3 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.17 EMD65732.1 - 2.8e-22 79.4 0.0 4.3e-22 78.8 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 EMD65732.1 - 0.0012 18.8 0.0 0.0037 17.2 0.0 1.8 1 0 0 1 1 1 1 PA domain Peptidase_M20 PF01546.28 EMD65732.1 - 0.015 15.0 0.0 0.028 14.1 0.0 1.4 1 1 0 1 1 1 0 Peptidase family M20/M25/M40 MARVEL PF01284.23 EMD65733.1 - 1.8e-26 92.9 5.1 2.5e-26 92.4 5.1 1.1 1 0 0 1 1 1 1 Membrane-associating domain Methyltransf_31 PF13847.6 EMD65734.1 - 3.6e-31 108.0 0.0 5.3e-31 107.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMD65734.1 - 7.3e-21 74.7 0.1 1.7e-20 73.5 0.0 1.6 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMD65734.1 - 1e-19 70.9 0.0 2.1e-19 69.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EMD65734.1 - 5.4e-16 58.9 0.0 1.2e-15 57.7 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMD65734.1 - 9.5e-16 58.4 0.0 1.7e-15 57.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EMD65734.1 - 2.6e-11 43.3 0.0 4.2e-11 42.6 0.0 1.3 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 EMD65734.1 - 9.7e-10 38.2 0.0 1.8e-09 37.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_4 PF02390.17 EMD65734.1 - 9.5e-07 28.4 0.0 1.7e-06 27.6 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_9 PF08003.11 EMD65734.1 - 1.5e-05 24.1 0.0 2.1e-05 23.6 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) PCMT PF01135.19 EMD65734.1 - 5.7e-05 23.0 0.0 8.6e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_18 PF12847.7 EMD65734.1 - 6.1e-05 23.0 0.0 0.0001 22.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 EMD65734.1 - 6.4e-05 23.0 0.0 0.00011 22.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.12 EMD65734.1 - 0.00011 21.8 0.0 0.0002 21.0 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW PrmA PF06325.13 EMD65734.1 - 0.00017 21.1 0.0 0.00027 20.4 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) CMAS PF02353.20 EMD65734.1 - 0.002 17.5 0.0 0.0027 17.0 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_2 PF00891.18 EMD65734.1 - 0.0034 16.7 0.0 0.0045 16.3 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain TehB PF03848.14 EMD65734.1 - 0.0038 16.6 0.0 0.006 16.0 0.0 1.2 1 0 0 1 1 1 1 Tellurite resistance protein TehB Methyltr_RsmB-F PF01189.17 EMD65734.1 - 0.0061 16.2 0.0 0.01 15.5 0.0 1.3 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F DREV PF05219.12 EMD65734.1 - 0.0068 15.5 0.0 0.011 14.9 0.0 1.2 1 0 0 1 1 1 1 DREV methyltransferase DUF938 PF06080.12 EMD65734.1 - 0.022 14.5 0.0 0.033 13.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF938) GidB PF02527.15 EMD65734.1 - 0.033 13.5 0.0 0.053 12.8 0.0 1.3 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G NodS PF05401.11 EMD65734.1 - 0.075 12.6 0.0 0.11 12.1 0.0 1.2 1 0 0 1 1 1 0 Nodulation protein S (NodS) RrnaAD PF00398.20 EMD65734.1 - 0.083 11.9 0.0 0.11 11.5 0.0 1.1 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase FtsJ PF01728.19 EMD65734.1 - 0.085 13.0 0.0 0.12 12.5 0.0 1.2 1 0 0 1 1 1 0 FtsJ-like methyltransferase MMM1 PF10296.9 EMD65736.1 - 0.0064 15.6 0.2 0.035 13.1 0.1 2.3 1 1 1 2 2 2 1 Maintenance of mitochondrial morphology protein 1 PH PF00169.29 EMD65736.1 - 0.013 16.0 0.1 0.044 14.3 0.0 1.9 2 0 0 2 2 2 0 PH domain PH_11 PF15413.6 EMD65736.1 - 0.042 14.3 1.7 0.084 13.3 0.0 2.4 3 0 0 3 3 3 0 Pleckstrin homology domain MoaE PF02391.17 EMD65737.1 - 3.9e-35 120.6 0.0 5e-35 120.2 0.0 1.1 1 0 0 1 1 1 1 MoaE protein TLD PF07534.16 EMD65738.1 - 5.6e-27 94.6 0.0 2.1e-26 92.8 0.0 1.8 1 1 0 1 1 1 1 TLD DUF1773 PF08593.10 EMD65738.1 - 4.1e-18 66.2 0.2 8.2e-18 65.2 0.2 1.5 1 0 0 1 1 1 1 Domain of unknown function Ribosomal_L36 PF00444.18 EMD65739.1 - 3.8e-18 65.4 12.3 5.5e-18 64.9 12.3 1.3 1 0 0 1 1 1 1 Ribosomal protein L36 Spectrin PF00435.21 EMD65740.1 - 0.00021 21.7 16.7 0.083 13.4 1.5 3.2 2 1 1 3 3 3 2 Spectrin repeat Fez1 PF06818.15 EMD65740.1 - 0.00033 21.2 17.6 0.0028 18.1 12.3 2.0 2 0 0 2 2 2 1 Fez1 Tropomyosin_1 PF12718.7 EMD65740.1 - 0.00039 20.6 6.7 0.00039 20.6 6.7 3.1 2 1 1 3 3 3 1 Tropomyosin like HOOK PF05622.12 EMD65740.1 - 0.00049 18.4 13.8 0.0053 15.0 11.4 2.0 2 0 0 2 2 2 1 HOOK protein HALZ PF02183.18 EMD65740.1 - 0.00065 19.9 5.9 0.25 11.6 0.2 3.4 2 1 1 3 3 3 1 Homeobox associated leucine zipper CENP-Q PF13094.6 EMD65740.1 - 0.0019 18.5 15.2 0.0032 17.7 4.2 2.3 1 1 1 2 2 2 1 CENP-Q, a CENPA-CAD centromere complex subunit Sec34 PF04136.15 EMD65740.1 - 0.0021 18.0 11.4 0.12 12.3 0.2 2.6 2 1 1 3 3 3 2 Sec34-like family UPF0242 PF06785.11 EMD65740.1 - 0.004 17.3 18.1 0.89 9.6 0.9 2.3 1 1 1 2 2 2 2 Uncharacterised protein family (UPF0242) N-terminus ADIP PF11559.8 EMD65740.1 - 0.0041 17.2 22.9 0.022 14.8 9.9 2.8 2 1 1 3 3 3 2 Afadin- and alpha -actinin-Binding Leu_zip PF15294.6 EMD65740.1 - 0.0071 15.9 13.3 0.43 10.1 8.0 2.2 1 1 1 2 2 2 2 Leucine zipper TPR_MLP1_2 PF07926.12 EMD65740.1 - 0.0083 16.2 24.0 2.6 8.1 10.0 3.4 2 1 1 3 3 3 2 TPR/MLP1/MLP2-like protein Cep57_MT_bd PF06657.13 EMD65740.1 - 0.0093 16.4 13.6 0.48 10.9 0.3 3.9 3 1 1 4 4 4 2 Centrosome microtubule-binding domain of Cep57 CENP-F_leu_zip PF10473.9 EMD65740.1 - 0.014 15.4 20.2 0.34 10.9 11.7 3.3 2 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TMF_TATA_bd PF12325.8 EMD65740.1 - 0.017 15.3 21.7 0.3 11.3 4.2 3.3 2 1 1 3 3 3 0 TATA element modulatory factor 1 TATA binding Laminin_I PF06008.14 EMD65740.1 - 0.024 14.4 14.4 0.23 11.1 7.2 2.2 2 0 0 2 2 2 0 Laminin Domain I ERM PF00769.19 EMD65740.1 - 0.042 13.7 16.8 0.036 13.9 8.8 2.0 1 1 1 2 2 2 0 Ezrin/radixin/moesin family APG6_N PF17675.1 EMD65740.1 - 0.043 14.4 21.2 0.59 10.7 14.6 2.6 1 1 0 2 2 2 0 Apg6 coiled-coil region AAA_13 PF13166.6 EMD65740.1 - 0.043 12.5 10.8 0.31 9.6 6.9 2.1 2 0 0 2 2 2 0 AAA domain HAUS-augmin3 PF14932.6 EMD65740.1 - 0.057 13.0 19.1 1.2 8.6 0.1 3.0 2 1 1 3 3 3 0 HAUS augmin-like complex subunit 3 Taxilin PF09728.9 EMD65740.1 - 0.11 11.7 17.0 0.1 11.8 6.2 2.9 2 1 1 3 3 3 0 Myosin-like coiled-coil protein TRAF_BIRC3_bd PF16673.5 EMD65740.1 - 0.12 12.2 9.9 1.4 8.8 0.2 3.7 3 1 0 4 4 4 0 TNF receptor-associated factor BIRC3 binding domain ATG16 PF08614.11 EMD65740.1 - 0.24 11.6 24.9 0.39 10.9 12.5 2.7 1 1 1 3 3 3 0 Autophagy protein 16 (ATG16) Cep57_CLD_2 PF14197.6 EMD65740.1 - 0.28 11.3 16.7 0.6 10.2 2.4 3.5 2 1 1 3 3 3 0 Centrosome localisation domain of PPC89 DUF1192 PF06698.11 EMD65740.1 - 0.32 11.1 2.5 4 7.5 0.1 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) Cnn_1N PF07989.11 EMD65740.1 - 0.32 11.2 17.0 11 6.2 0.2 3.9 2 1 2 4 4 4 0 Centrosomin N-terminal motif 1 DUF4200 PF13863.6 EMD65740.1 - 0.36 11.2 18.3 5.1 7.5 14.2 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4200) Fib_alpha PF08702.10 EMD65740.1 - 0.38 10.9 14.1 3 8.0 2.1 3.2 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family Lebercilin PF15619.6 EMD65740.1 - 0.4 10.3 26.5 0.2 11.3 12.7 3.0 2 1 1 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease DUF4988 PF16378.5 EMD65740.1 - 0.44 10.2 3.4 3.3 7.3 0.2 2.6 2 1 0 2 2 2 0 Domain of unknown function FlaC_arch PF05377.11 EMD65740.1 - 0.48 10.9 13.4 0.5 10.8 0.4 4.1 4 1 1 5 5 4 0 Flagella accessory protein C (FlaC) ABC_tran_CTD PF16326.5 EMD65740.1 - 0.49 10.7 15.4 0.26 11.6 2.5 4.1 2 1 2 4 4 4 0 ABC transporter C-terminal domain DivIVA PF05103.13 EMD65740.1 - 0.57 10.3 16.3 4.3 7.4 9.2 2.6 2 1 0 2 2 2 0 DivIVA protein Syntaxin-6_N PF09177.11 EMD65740.1 - 0.64 10.6 13.6 2.9 8.5 0.3 3.1 2 1 0 2 2 2 0 Syntaxin 6, N-terminal DUF4201 PF13870.6 EMD65740.1 - 0.66 9.7 16.5 0.33 10.7 10.9 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4201) Spc7 PF08317.11 EMD65740.1 - 0.69 8.7 20.8 2.1 7.1 13.9 2.4 2 1 0 2 2 2 0 Spc7 kinetochore protein LPP PF04728.13 EMD65740.1 - 0.79 10.2 5.0 13 6.3 0.7 3.0 2 0 0 2 2 2 0 Lipoprotein leucine-zipper Prefoldin_2 PF01920.20 EMD65740.1 - 0.83 9.6 21.5 0.72 9.8 1.1 3.9 3 1 2 5 5 5 0 Prefoldin subunit DUF5082 PF16888.5 EMD65740.1 - 0.84 9.9 15.5 1.2 9.5 2.8 3.5 3 2 1 4 4 4 0 Domain of unknown function (DUF5082) Vps51 PF08700.11 EMD65740.1 - 0.93 9.6 7.4 2.1 8.5 0.2 3.5 3 0 0 3 3 3 0 Vps51/Vps67 Occludin_ELL PF07303.13 EMD65740.1 - 1 10.1 8.7 7.9 7.3 0.0 3.1 2 1 0 2 2 2 0 Occludin homology domain DUF4407 PF14362.6 EMD65740.1 - 1.2 8.5 16.3 31 3.8 16.3 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Surfac_D-trimer PF09006.11 EMD65740.1 - 1.3 9.0 4.1 15 5.6 0.1 3.1 3 0 0 3 3 3 0 Lung surfactant protein D coiled-coil trimerisation FapA PF03961.13 EMD65740.1 - 1.7 7.1 12.3 1 7.9 7.5 2.0 1 1 0 2 2 2 0 Flagellar Assembly Protein A DUF3450 PF11932.8 EMD65740.1 - 2.1 7.6 26.0 2.2 7.5 1.3 3.8 2 1 1 3 3 3 0 Protein of unknown function (DUF3450) DivIC PF04977.15 EMD65740.1 - 2.5 7.9 19.2 0.91 9.3 0.3 4.0 2 2 2 5 5 5 0 Septum formation initiator JIP_LZII PF16471.5 EMD65740.1 - 2.6 8.3 17.2 10 6.4 2.1 4.3 3 1 1 4 4 4 0 JNK-interacting protein leucine zipper II Rootletin PF15035.6 EMD65740.1 - 2.6 8.0 19.3 9.6 6.2 3.1 2.6 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion LRRFIP PF09738.9 EMD65740.1 - 2.7 7.4 18.1 3.8e+02 0.3 18.1 3.0 1 1 0 1 1 1 0 LRRFIP family DUF724 PF05266.14 EMD65740.1 - 3.1 7.6 14.1 1.8 8.4 4.0 2.7 2 1 2 4 4 4 0 Protein of unknown function (DUF724) BLOC1_2 PF10046.9 EMD65740.1 - 3.1 8.2 15.5 6.2 7.2 4.9 3.1 3 1 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF1664 PF07889.12 EMD65740.1 - 3.6 7.7 11.3 3.7 7.6 2.9 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) Uso1_p115_C PF04871.13 EMD65740.1 - 3.9 7.9 18.4 40 4.6 12.7 3.0 2 1 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region THOC7 PF05615.13 EMD65740.1 - 3.9 7.8 20.8 7.8 6.8 13.2 2.9 2 1 0 2 2 2 0 Tho complex subunit 7 HalX PF08663.10 EMD65740.1 - 4.2 7.8 17.4 0.13 12.6 4.3 3.7 3 1 1 4 4 4 0 HalX domain Filament PF00038.21 EMD65740.1 - 4.8 6.7 23.4 0.77 9.3 1.0 2.9 2 1 0 2 2 2 0 Intermediate filament protein Bap31_Bap29_C PF18035.1 EMD65740.1 - 5.9 7.0 10.3 1.6e+03 -0.8 10.3 3.1 1 1 0 1 1 1 0 Bap31/Bap29 cytoplasmic coiled-coil domain Spc24 PF08286.11 EMD65740.1 - 6.1 7.1 17.7 5.9 7.2 0.3 3.8 2 1 1 3 3 3 0 Spc24 subunit of Ndc80 BRE1 PF08647.11 EMD65740.1 - 9.5 6.4 18.4 1.3 9.1 8.4 3.2 2 1 1 3 3 3 0 BRE1 E3 ubiquitin ligase Glucosamine_iso PF01182.20 EMD65742.1 - 3.4e-68 229.9 0.0 3.8e-68 229.7 0.0 1.0 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase AAA_22 PF13401.6 EMD65742.1 - 0.071 13.4 0.0 0.12 12.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain SR-25 PF10500.9 EMD65743.1 - 2 8.0 8.1 2.6 7.6 8.1 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein KAR9 PF08580.10 EMD65743.1 - 6.4 5.2 8.5 6.6 5.2 8.5 1.1 1 0 0 1 1 1 0 Yeast cortical protein KAR9 DUF2608 PF11019.8 EMD65745.1 - 0.0076 15.8 0.1 0.0098 15.4 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2608) DUF1775 PF07987.11 EMD65745.1 - 0.039 14.2 0.0 0.046 14.0 0.0 1.1 1 0 0 1 1 1 0 Domain of unkown function (DUF1775) DUF3958 PF13125.6 EMD65746.1 - 0.024 14.8 4.8 0.031 14.5 4.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3958) Metal_resist PF13801.6 EMD65746.1 - 0.054 13.7 0.2 0.058 13.6 0.2 1.1 1 0 0 1 1 1 0 Heavy-metal resistance Cep57_MT_bd PF06657.13 EMD65746.1 - 0.064 13.7 3.9 0.083 13.4 3.9 1.1 1 0 0 1 1 1 0 Centrosome microtubule-binding domain of Cep57 FliP PF00813.20 EMD65746.1 - 0.082 12.8 0.0 0.085 12.7 0.0 1.0 1 0 0 1 1 1 0 FliP family Spt20 PF12090.8 EMD65747.1 - 0.0082 15.8 5.7 0.013 15.1 5.7 1.3 1 0 0 1 1 1 1 Spt20 family DUF3464 PF11947.8 EMD65747.1 - 0.018 14.8 1.3 0.042 13.6 1.3 1.6 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Connexin PF00029.19 EMD65747.1 - 0.13 12.1 0.2 0.2 11.4 0.2 1.2 1 0 0 1 1 1 0 Connexin Presenilin PF01080.17 EMD65747.1 - 0.53 9.0 3.6 0.89 8.3 3.6 1.3 1 0 0 1 1 1 0 Presenilin DUF4834 PF16118.5 EMD65747.1 - 0.56 11.2 2.5 1.4 9.9 2.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) HEAT_PBS PF03130.16 EMD65749.1 - 0.52 11.1 0.1 0.52 11.1 0.1 2.2 2 0 0 2 2 2 0 PBS lyase HEAT-like repeat DUF3431 PF11913.8 EMD65750.1 - 6.3e-87 290.9 0.2 8e-87 290.5 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3431) RRM_1 PF00076.22 EMD65751.1 - 1e-19 70.1 0.0 1.4e-19 69.6 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EMD65751.1 - 8e-05 22.2 0.0 0.00011 21.8 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) EPL1 PF10513.9 EMD65752.1 - 3.8e-32 111.9 0.0 3.8e-32 111.9 0.0 2.9 3 1 0 3 3 3 1 Enhancer of polycomb-like zf-HC5HC2H_2 PF13832.6 EMD65752.1 - 3.6e-31 107.6 10.7 3.6e-31 107.6 10.7 2.4 2 0 0 2 2 2 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 EMD65752.1 - 1.9e-25 88.9 17.9 3e-25 88.3 8.9 2.6 2 0 0 2 2 2 2 PHD-like zinc-binding domain PHD_2 PF13831.6 EMD65752.1 - 1.7e-14 53.1 1.8 1.7e-14 53.1 1.8 2.3 2 0 0 2 2 2 1 PHD-finger PHD PF00628.29 EMD65752.1 - 1.3e-08 34.6 9.1 1.3e-08 34.6 9.1 2.7 2 0 0 2 2 2 1 PHD-finger zf-PHD-like PF15446.6 EMD65752.1 - 9.7 5.8 14.3 0.032 13.9 2.6 2.4 2 0 0 2 2 2 0 PHD/FYVE-zinc-finger like domain LRR_4 PF12799.7 EMD65753.1 - 5.6e-05 23.4 6.3 2.9 8.4 2.2 5.5 4 1 1 5 5 5 2 Leucine Rich repeats (2 copies) F-box-like PF12937.7 EMD65753.1 - 0.00023 21.0 0.7 0.00057 19.7 0.7 1.6 1 0 0 1 1 1 1 F-box-like FCH PF00611.23 EMD65753.1 - 0.073 13.4 0.0 0.15 12.4 0.0 1.5 1 0 0 1 1 1 0 Fes/CIP4, and EFC/F-BAR homology domain zf-CCHC PF00098.23 EMD65754.1 - 6.3e-08 32.4 3.2 9.7e-08 31.8 3.2 1.3 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_5 PF14787.6 EMD65754.1 - 0.0039 16.9 0.2 0.0066 16.1 0.2 1.4 1 0 0 1 1 1 1 GAG-polyprotein viral zinc-finger ATF7IP_BD PF16788.5 EMD65754.1 - 0.013 15.6 0.0 0.015 15.4 0.0 1.1 1 0 0 1 1 1 0 ATF-interacting protein binding domain zf-CCHC_2 PF13696.6 EMD65754.1 - 0.063 13.1 2.1 0.11 12.3 2.1 1.4 1 0 0 1 1 1 0 Zinc knuckle zf-C2H2_10 PF16588.5 EMD65754.1 - 0.31 10.8 1.9 0.55 10.0 1.9 1.3 1 0 0 1 1 1 0 C2H2 zinc-finger Nnf1 PF03980.14 EMD65755.1 - 4.6e-27 94.6 0.4 4.6e-27 94.6 0.4 1.7 2 0 0 2 2 2 1 Nnf1 SlyX PF04102.12 EMD65755.1 - 0.0018 18.9 5.2 0.17 12.5 3.2 2.8 2 1 0 2 2 2 2 SlyX GAS PF13851.6 EMD65755.1 - 0.0022 17.4 1.5 0.0022 17.4 1.5 1.6 2 0 0 2 2 2 1 Growth-arrest specific micro-tubule binding DUF892 PF05974.12 EMD65755.1 - 0.0046 17.0 2.4 0.0094 16.0 2.4 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF892) Med30 PF11315.8 EMD65755.1 - 0.083 13.1 1.7 4 7.6 0.1 2.5 1 1 1 2 2 2 0 Mediator complex subunit 30 Cytochrom_B562 PF07361.11 EMD65755.1 - 0.092 13.4 2.7 0.16 12.6 1.4 1.9 2 1 0 2 2 2 0 Cytochrome b562 NAD_binding_2 PF03446.15 EMD65756.1 - 4.3e-33 114.7 0.2 7.4e-33 113.9 0.2 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 EMD65756.1 - 5e-33 113.9 0.4 9.8e-22 77.5 0.0 2.3 2 0 0 2 2 2 2 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase 3HCDH_N PF02737.18 EMD65756.1 - 0.00048 20.1 0.0 0.001 19.0 0.0 1.6 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain F420_oxidored PF03807.17 EMD65756.1 - 0.025 15.2 0.0 0.082 13.5 0.0 2.0 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent ApbA PF02558.16 EMD65756.1 - 0.081 12.6 0.0 0.18 11.4 0.0 1.6 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Pil1 PF13805.6 EMD65758.1 - 2.6e-122 407.4 0.1 3.7e-122 406.9 0.1 1.2 1 0 0 1 1 1 1 Eisosome component PIL1 Tom37 PF10568.9 EMD65758.1 - 4.4e-31 107.8 0.0 1.1e-30 106.5 0.0 1.7 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein GST_C_6 PF17171.4 EMD65758.1 - 8.3e-17 60.7 0.1 4.4e-16 58.4 0.0 2.3 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EMD65758.1 - 8.8e-06 25.7 0.4 2.3e-05 24.3 0.1 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain FAM92 PF06730.11 EMD65758.1 - 0.18 11.2 2.1 0.24 10.8 1.1 1.6 1 1 0 1 1 1 0 FAM92 protein GFO_IDH_MocA PF01408.22 EMD65760.1 - 5.4e-12 46.6 0.0 8.2e-12 46.0 0.0 1.2 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold DXP_reductoisom PF02670.16 EMD65760.1 - 0.2 12.4 0.0 0.32 11.7 0.0 1.3 1 0 0 1 1 1 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase Peptidase_S28 PF05577.12 EMD65761.1 - 1.3e-43 149.4 1.0 2.7e-33 115.4 0.0 2.1 2 0 0 2 2 2 2 Serine carboxypeptidase S28 Neurexophilin PF06312.12 EMD65761.1 - 0.0032 16.9 0.0 0.007 15.8 0.0 1.5 1 0 0 1 1 1 1 Neurexophilin HET PF06985.11 EMD65762.1 - 3.7e-24 85.8 1.5 2.4e-20 73.4 0.0 2.4 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) Abhydrolase_6 PF12697.7 EMD65763.1 - 0.00025 21.7 0.5 0.00049 20.8 0.5 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family EthD PF07110.11 EMD65764.1 - 0.011 16.9 0.0 0.018 16.2 0.0 1.4 1 1 0 1 1 1 0 EthD domain VirArc_Nuclease PF12187.8 EMD65764.1 - 0.069 12.7 0.0 0.08 12.5 0.0 1.1 1 0 0 1 1 1 0 Viral/Archaeal nuclease DUF1330 PF07045.11 EMD65764.1 - 0.098 13.0 0.0 0.16 12.4 0.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF1330) Cellulase PF00150.18 EMD65765.1 - 4.8e-39 134.5 3.6 4.8e-39 134.5 3.6 2.1 2 0 0 2 2 2 1 Cellulase (glycosyl hydrolase family 5) CBM_X2 PF03442.14 EMD65765.1 - 2.4e-24 85.2 2.2 2.6e-22 78.7 2.7 2.6 2 0 0 2 2 2 1 Carbohydrate binding domain X2 SecE PF00584.20 EMD65767.1 - 5.5e-16 58.2 0.1 6.2e-16 58.1 0.1 1.1 1 0 0 1 1 1 1 SecE/Sec61-gamma subunits of protein translocation complex WD40 PF00400.32 EMD65768.1 - 2.2e-23 82.1 20.6 8.4e-05 23.3 0.2 7.5 7 0 0 7 7 7 5 WD domain, G-beta repeat Cytochrom_D1 PF02239.16 EMD65768.1 - 0.0014 17.2 1.0 0.15 10.6 0.0 3.5 3 1 1 4 4 4 1 Cytochrome D1 heme domain PQQ_3 PF13570.6 EMD65768.1 - 0.0073 16.8 0.5 6.9 7.3 0.1 3.2 3 0 0 3 3 3 2 PQQ-like domain ANAPC4_WD40 PF12894.7 EMD65768.1 - 0.044 14.1 0.0 1.1 9.6 0.0 3.0 3 1 1 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain FRQ PF09421.10 EMD65768.1 - 1.3 7.0 8.5 1.9 6.4 8.5 1.1 1 0 0 1 1 1 0 Frequency clock protein Radial_spoke PF04712.12 EMD65768.1 - 2.5 7.0 8.3 5.1 5.9 8.3 1.6 1 0 0 1 1 1 0 Radial spokehead-like protein DUF2722 PF10846.8 EMD65768.1 - 3.3 6.5 4.5 4.9 6.0 4.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Exonuc_VII_L PF02601.15 EMD65769.1 - 0.045 13.3 9.9 0.24 11.0 6.3 2.2 2 0 0 2 2 2 0 Exonuclease VII, large subunit ING PF12998.7 EMD65769.1 - 0.067 13.8 7.7 6.1 7.5 0.0 3.5 3 1 0 3 3 3 0 Inhibitor of growth proteins N-terminal histone-binding RRP36 PF06102.12 EMD65769.1 - 0.088 12.8 7.7 0.24 11.4 7.7 1.7 1 0 0 1 1 1 0 rRNA biogenesis protein RRP36 DUF724 PF05266.14 EMD65769.1 - 0.22 11.3 11.8 0.13 12.1 8.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF724) DUF1043 PF06295.12 EMD65769.1 - 0.27 11.3 0.0 0.27 11.3 0.0 3.0 4 0 0 4 4 4 0 Protein of unknown function (DUF1043) Bacillus_HBL PF05791.11 EMD65769.1 - 0.46 10.3 3.2 7.7 6.3 1.3 2.3 2 0 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) Prominin PF05478.11 EMD65769.1 - 0.46 8.4 4.8 0.38 8.7 3.3 1.5 2 0 0 2 2 2 0 Prominin SKA2 PF16740.5 EMD65769.1 - 0.55 10.0 15.8 8.2 6.3 0.1 4.9 3 2 1 5 5 5 0 Spindle and kinetochore-associated protein 2 Wtap PF17098.5 EMD65769.1 - 1 9.3 11.2 0.45 10.4 8.0 2.0 2 0 0 2 2 2 0 WTAP/Mum2p family NPV_P10 PF05531.12 EMD65769.1 - 2.3 8.7 6.7 2.1 8.9 0.2 3.6 4 0 0 4 4 4 0 Nucleopolyhedrovirus P10 protein Fib_alpha PF08702.10 EMD65769.1 - 3.1 8.0 12.5 0.67 10.1 6.1 2.5 3 0 0 3 3 3 0 Fibrinogen alpha/beta chain family Filament PF00038.21 EMD65769.1 - 4 6.9 17.4 0.49 9.9 9.6 2.7 2 1 1 3 3 3 0 Intermediate filament protein Seryl_tRNA_N PF02403.22 EMD65769.1 - 5.2 7.4 19.0 1.1 9.5 10.5 3.6 3 1 1 4 4 4 0 Seryl-tRNA synthetase N-terminal domain Ribosomal_S5 PF00333.20 EMD65770.1 - 1.6e-27 95.3 1.3 3.6e-27 94.1 1.3 1.6 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.15 EMD65770.1 - 2.5e-23 81.3 0.0 4.3e-23 80.5 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain FoP_duplication PF13865.6 EMD65770.1 - 0.49 11.0 9.9 1.1 9.8 9.9 1.5 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 Aldedh PF00171.22 EMD65771.1 - 8.7e-168 558.6 0.4 9.8e-168 558.4 0.4 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 EMD65771.1 - 0.032 13.7 0.0 0.093 12.2 0.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1487) AAA PF00004.29 EMD65772.1 - 1e-47 161.9 0.0 2e-41 141.5 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EMD65772.1 - 3e-10 39.7 0.0 1.3e-09 37.7 0.0 2.1 1 0 0 1 1 1 1 AAA+ lid domain IstB_IS21 PF01695.17 EMD65772.1 - 4.5e-07 29.8 0.0 1.8e-06 27.8 0.0 1.9 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_16 PF13191.6 EMD65772.1 - 6.1e-07 30.0 0.1 2.4e-05 24.8 0.0 3.5 3 0 0 3 3 3 1 AAA ATPase domain AAA_2 PF07724.14 EMD65772.1 - 1.4e-05 25.2 0.0 4.3e-05 23.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) Bromodomain PF00439.25 EMD65772.1 - 0.00028 20.9 0.1 0.0008 19.4 0.1 1.7 1 0 0 1 1 1 1 Bromodomain AAA_5 PF07728.14 EMD65772.1 - 0.00032 20.7 0.0 0.0012 18.8 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 EMD65772.1 - 0.0015 18.9 0.0 0.0064 16.9 0.0 2.1 2 0 0 2 2 1 1 RNA helicase AAA_22 PF13401.6 EMD65772.1 - 0.0021 18.4 0.5 0.042 14.1 0.2 3.0 2 1 0 2 2 1 1 AAA domain AAA_25 PF13481.6 EMD65772.1 - 0.0032 17.1 0.0 0.023 14.3 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EMD65772.1 - 0.0072 16.5 0.1 0.04 14.1 0.0 2.4 2 0 0 2 2 1 1 AAA domain AAA_14 PF13173.6 EMD65772.1 - 0.011 15.8 0.0 0.031 14.3 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 EMD65772.1 - 0.014 15.1 0.0 0.038 13.7 0.0 1.8 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EMD65772.1 - 0.015 15.8 0.0 0.065 13.8 0.0 2.1 1 0 0 1 1 1 0 ABC transporter TIP49 PF06068.13 EMD65772.1 - 0.016 14.5 0.3 0.035 13.3 0.0 1.6 2 0 0 2 2 2 0 TIP49 P-loop domain AAA_18 PF13238.6 EMD65772.1 - 0.017 15.6 0.1 0.09 13.3 0.0 2.3 2 0 0 2 2 1 0 AAA domain Mg_chelatase PF01078.21 EMD65772.1 - 0.018 14.4 0.0 0.069 12.5 0.0 1.9 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Parvo_NS1 PF01057.17 EMD65772.1 - 0.046 12.8 0.0 0.089 11.9 0.0 1.4 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 RuvB_N PF05496.12 EMD65772.1 - 0.056 13.2 0.0 0.15 11.8 0.0 1.7 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain NACHT PF05729.12 EMD65772.1 - 0.061 13.2 0.0 0.15 11.9 0.0 1.7 1 0 0 1 1 1 0 NACHT domain AAA_28 PF13521.6 EMD65772.1 - 0.063 13.5 0.0 0.21 11.8 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_3 PF07726.11 EMD65772.1 - 0.1 12.5 0.0 0.28 11.0 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) PhoH PF02562.16 EMD65772.1 - 0.14 11.6 0.1 0.54 9.7 0.0 2.0 2 0 0 2 2 2 0 PhoH-like protein AAA_11 PF13086.6 EMD65772.1 - 0.39 10.5 0.0 0.39 10.5 0.0 3.7 4 0 0 4 4 3 0 AAA domain Peptidase_Mx PF15887.5 EMD65774.1 - 0.073 12.5 0.3 0.1 11.9 0.3 1.2 1 0 0 1 1 1 0 Putative zinc-binding metallo-peptidase HrpE PF06188.12 EMD65774.1 - 0.1 12.5 0.9 2.1 8.2 0.5 2.3 1 1 0 2 2 2 0 HrpE/YscL/FliH and V-type ATPase subunit E RecO_C PF02565.15 EMD65776.1 - 0.12 12.1 0.0 0.14 12.0 0.0 1.0 1 0 0 1 1 1 0 Recombination protein O C terminal Cyclin_N PF00134.23 EMD65777.1 - 1.8e-38 131.2 0.7 3.2e-38 130.3 0.7 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 EMD65777.1 - 7.9e-11 42.1 0.2 2.5e-10 40.5 0.2 1.9 1 0 0 1 1 1 1 Cyclin, C-terminal domain ANAPC4_WD40 PF12894.7 EMD65778.1 - 2.1e-07 31.1 0.6 1 9.7 0.0 6.3 5 2 1 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EMD65778.1 - 2.9e-07 31.0 2.7 8.4 7.4 0.0 7.8 9 1 0 9 9 9 2 WD domain, G-beta repeat PQQ_2 PF13360.6 EMD65778.1 - 0.0003 20.5 0.0 0.023 14.3 0.1 3.4 2 1 1 3 3 3 1 PQQ-like domain FliO PF04347.13 EMD65778.1 - 0.082 13.2 0.0 2.4 8.5 0.0 2.8 2 0 0 2 2 2 0 Flagellar biosynthesis protein, FliO SUR7 PF06687.12 EMD65779.1 - 9.8e-37 126.6 1.2 1.2e-36 126.4 1.2 1.1 1 0 0 1 1 1 1 SUR7/PalI family Peptidase_C97 PF05903.14 EMD65779.1 - 0.1 12.4 0.2 0.27 11.1 0.1 1.7 2 0 0 2 2 2 0 PPPDE putative peptidase domain Rad4 PF03835.15 EMD65780.1 - 3.7e-14 52.7 2.1 4.5e-14 52.4 1.2 1.6 2 0 0 2 2 2 1 Rad4 transglutaminase-like domain Transglut_core PF01841.19 EMD65780.1 - 3.2e-13 50.1 2.0 3.2e-13 50.1 2.0 2.0 2 0 0 2 2 2 1 Transglutaminase-like superfamily Na_H_Exchanger PF00999.21 EMD65781.1 - 1.5e-58 198.4 42.4 2.2e-58 197.9 42.4 1.2 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family SUKH-4 PF14435.6 EMD65781.1 - 0.024 14.7 0.3 2.8 8.0 0.0 2.5 2 1 0 2 2 2 0 SUKH-4 immunity protein Syntaxin PF00804.25 EMD65783.1 - 2.5e-19 69.7 5.0 2.5e-19 69.7 5.0 1.9 2 1 0 2 2 2 1 Syntaxin SNARE PF05739.19 EMD65783.1 - 1.5e-08 34.5 7.1 1.7e-08 34.3 3.7 2.5 2 0 0 2 2 2 1 SNARE domain Use1 PF09753.9 EMD65783.1 - 6.2e-05 22.9 0.6 8.6e-05 22.4 0.6 1.2 1 0 0 1 1 1 1 Membrane fusion protein Use1 Tweety PF04906.13 EMD65783.1 - 0.0012 17.6 1.8 0.0021 16.8 1.8 1.3 1 0 0 1 1 1 1 Tweety DUF2207 PF09972.9 EMD65783.1 - 0.0053 15.6 0.0 0.007 15.2 0.0 1.2 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) MCU PF04678.13 EMD65783.1 - 0.007 16.5 2.1 0.02 15.0 2.0 1.8 1 1 0 1 1 1 1 Mitochondrial calcium uniporter RPW8 PF05659.11 EMD65783.1 - 0.008 15.9 0.4 0.056 13.1 0.4 2.0 2 0 0 2 2 2 1 Arabidopsis broad-spectrum mildew resistance protein RPW8 AAA_23 PF13476.6 EMD65783.1 - 0.014 15.9 2.0 0.019 15.5 2.0 1.3 1 0 0 1 1 1 0 AAA domain Spc29 PF17082.5 EMD65783.1 - 0.059 13.2 4.9 0.41 10.5 3.0 2.1 1 1 1 2 2 2 0 Spindle Pole Component 29 DUF4094 PF13334.6 EMD65783.1 - 0.063 13.7 0.1 0.73 10.3 0.3 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4094) DUF1664 PF07889.12 EMD65783.1 - 0.081 13.0 3.0 3.3 7.8 1.7 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) Fusion_F0 PF13044.6 EMD65783.1 - 0.12 11.0 0.2 0.2 10.3 0.2 1.3 1 0 0 1 1 1 0 Fusion glycoprotein F0, Isavirus Pox_EPC_I2-L1 PF12575.8 EMD65783.1 - 0.14 12.4 0.4 0.24 11.7 0.4 1.3 1 0 0 1 1 1 0 Poxvirus entry protein complex L1 and I2 BLOC1_2 PF10046.9 EMD65783.1 - 0.16 12.3 4.1 0.62 10.4 2.0 2.8 3 1 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Noelin-1 PF12308.8 EMD65783.1 - 0.42 10.6 2.6 0.68 9.9 0.8 2.2 3 0 0 3 3 3 0 Neurogenesis glycoprotein zf-CpG_bind_C PF12269.8 EMD65783.1 - 0.61 9.8 4.6 9.6 5.9 2.1 2.7 2 1 1 3 3 3 0 CpG binding protein zinc finger C terminal domain DUF2203 PF09969.9 EMD65783.1 - 0.92 10.2 6.4 0.58 10.9 1.3 2.5 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2203) DHR10 PF18595.1 EMD65783.1 - 2.3 8.3 11.5 0.46 10.6 3.5 2.8 3 0 0 3 3 3 0 Designed helical repeat protein 10 domain Baculo_F PF12259.8 EMD65783.1 - 3 6.2 0.0 3 6.2 0.0 2.9 2 1 1 3 3 3 0 Baculovirus F protein DUF948 PF06103.11 EMD65783.1 - 9.2 6.6 11.7 1.2 9.4 1.3 3.3 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) Abhydrolase_9_N PF15420.6 EMD65784.1 - 0.0058 16.7 9.2 0.0076 16.3 9.2 1.1 1 0 0 1 1 1 1 Alpha/beta-hydrolase family N-terminus TMEM43 PF07787.12 EMD65784.1 - 1.9 7.8 5.3 3.5 7.0 5.3 1.4 1 0 0 1 1 1 0 Transmembrane protein 43 NAPRTase PF04095.16 EMD65785.1 - 6.3e-56 189.7 1.1 9.2e-30 104.0 0.5 2.1 2 0 0 2 2 2 2 Nicotinate phosphoribosyltransferase (NAPRTase) family NAPRTase_N PF17767.1 EMD65785.1 - 1.2e-34 119.3 0.0 2.1e-34 118.6 0.0 1.4 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain Cyt-b5 PF00173.28 EMD65786.1 - 1.2e-16 60.6 0.0 1.9e-16 60.0 0.0 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Sugar_tr PF00083.24 EMD65787.1 - 1.6e-83 281.0 16.7 2e-83 280.7 16.7 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD65787.1 - 2.2e-32 112.4 13.3 2.2e-32 112.4 13.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 EMD65787.1 - 0.021 13.7 12.7 0.038 12.8 4.2 2.3 2 0 0 2 2 2 0 MFS_1 like family YMF19 PF02326.15 EMD65787.1 - 0.1 13.4 0.5 1.4 9.8 0.6 2.6 2 0 0 2 2 2 0 Plant ATP synthase F0 DUF3792 PF12670.7 EMD65787.1 - 2.7 8.2 16.4 0.023 14.9 4.9 3.0 2 1 0 2 2 2 0 Protein of unknown function (DUF3792) RPN2_C PF18004.1 EMD65789.1 - 1.6e-55 187.4 6.1 1.6e-55 187.4 6.1 2.0 2 0 0 2 2 2 1 26S proteasome regulatory subunit RPN2 C-terminal domain PC_rep PF01851.22 EMD65789.1 - 5.1e-38 127.6 23.2 1.7e-08 34.4 0.0 8.8 9 0 0 9 9 9 7 Proteasome/cyclosome repeat HEAT_2 PF13646.6 EMD65789.1 - 2.1e-21 76.1 0.2 1.5e-14 54.1 0.0 4.7 3 1 2 5 5 5 3 HEAT repeats HEAT_EZ PF13513.6 EMD65789.1 - 1.5e-06 28.6 0.0 0.0019 18.7 0.0 4.7 2 1 1 3 3 3 2 HEAT-like repeat HEAT PF02985.22 EMD65789.1 - 0.00041 20.4 2.3 14 6.2 0.0 5.8 6 0 0 6 6 6 2 HEAT repeat ANAPC3 PF12895.7 EMD65789.1 - 0.022 15.0 0.5 9.8 6.5 0.1 3.2 4 0 0 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 HEAT_PBS PF03130.16 EMD65789.1 - 0.26 12.1 0.7 14 6.7 0.0 3.9 3 0 0 3 3 3 0 PBS lyase HEAT-like repeat mRNA_triPase PF02940.15 EMD65790.1 - 7.5e-48 163.1 0.0 9.7e-48 162.8 0.0 1.1 1 0 0 1 1 1 1 mRNA capping enzyme, beta chain PK PF00224.21 EMD65791.1 - 4.7e-173 574.9 3.7 5.8e-173 574.6 3.7 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.16 EMD65791.1 - 7.5e-38 129.4 0.0 4.3e-37 126.9 0.0 2.3 2 0 0 2 2 2 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.14 EMD65791.1 - 0.0011 18.1 0.4 0.0029 16.8 0.1 1.8 2 0 0 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family IMPDH PF00478.25 EMD65791.1 - 0.049 12.6 0.0 0.2 10.6 0.0 1.9 2 0 0 2 2 2 0 IMP dehydrogenase / GMP reductase domain DUF1748 PF08520.10 EMD65792.1 - 1.9e-28 98.1 0.0 2.2e-28 98.0 0.0 1.0 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1748) NIBRIN_BRCT_II PF16508.5 EMD65793.1 - 1.4e-31 109.3 0.0 5e-30 104.3 0.0 2.8 3 0 0 3 3 3 1 Second BRCT domain on Nijmegen syndrome breakage protein RTT107_BRCT_5 PF16770.5 EMD65793.1 - 0.0037 17.1 0.9 0.011 15.6 0.0 2.1 2 0 0 2 2 2 1 Regulator of Ty1 transposition protein 107 BRCT domain FHA PF00498.26 EMD65793.1 - 0.0069 16.7 0.0 0.016 15.5 0.0 1.6 1 0 0 1 1 1 1 FHA domain DUF3336 PF11815.8 EMD65795.1 - 5.6e-34 116.8 0.5 9.7e-34 116.0 0.5 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Patatin PF01734.22 EMD65795.1 - 5.4e-22 79.0 0.0 1.3e-21 77.7 0.0 1.6 1 0 0 1 1 1 1 Patatin-like phospholipase AT_hook PF02178.19 EMD65796.1 - 0.016 15.0 1.1 0.016 15.0 1.1 2.8 2 0 0 2 2 2 0 AT hook motif YpmT PF17431.2 EMD65805.1 - 0.085 12.9 0.0 0.17 12.0 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized YmpT-like SLATT_fungal PF18142.1 EMD65807.1 - 0.073 13.1 0.0 0.073 13.1 0.0 3.4 2 1 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain HEAT_UF PF18817.1 EMD65807.1 - 0.093 13.0 0.7 21 5.5 0.1 3.5 3 0 0 3 3 3 0 Repeat of uncharacterized protein PH0542 Tropomyosin_1 PF12718.7 EMD65807.1 - 10 6.3 48.9 3.9 7.6 0.7 4.6 3 1 1 4 4 4 0 Tropomyosin like PUF PF00806.19 EMD65809.1 - 0.049 13.3 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 Pumilio-family RNA binding repeat Mo-co_dimer PF03404.16 EMD65810.1 - 0.039 14.0 0.0 0.067 13.2 0.0 1.5 1 1 0 1 1 1 0 Mo-co oxidoreductase dimerisation domain UbiA PF01040.18 EMD65812.1 - 3.8e-14 52.6 7.2 5.8e-14 52.0 7.2 1.3 1 1 0 1 1 1 1 UbiA prenyltransferase family ATP_synt_H PF05493.13 EMD65812.1 - 0.23 12.0 5.5 0.96 10.0 5.5 2.2 1 1 0 1 1 1 0 ATP synthase subunit H Glyco_hydro_61 PF03443.14 EMD65813.1 - 0.0098 15.8 0.3 0.023 14.6 0.3 1.6 1 1 0 1 1 1 1 Glycosyl hydrolase family 61 DUF5118 PF17162.4 EMD65813.1 - 0.17 11.8 0.0 0.28 11.0 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5118) RSN1_7TM PF02714.15 EMD65816.1 - 3.4e-60 203.7 22.9 4.3e-60 203.4 22.9 1.1 1 0 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate PHM7_cyt PF14703.6 EMD65816.1 - 6.8e-09 36.2 0.0 9.1e-09 35.8 0.0 1.2 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter PHM7_ext PF12621.8 EMD65816.1 - 0.015 15.5 0.0 0.026 14.7 0.0 1.4 1 0 0 1 1 1 0 Extracellular tail, of 10TM putative phosphate transporter BTB PF00651.31 EMD65817.1 - 1.2e-06 28.7 0.0 2.8e-06 27.5 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain DUF3135 PF11333.8 EMD65817.1 - 0.11 12.7 0.4 3.9 7.8 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3135) DUF3723 PF12520.8 EMD65819.1 - 7.2e-56 189.9 0.2 1e-55 189.4 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3723) GrpE PF01025.19 EMD65821.1 - 0.00058 19.5 0.9 0.00081 19.1 0.9 1.1 1 0 0 1 1 1 1 GrpE EzrA PF06160.12 EMD65821.1 - 0.0027 16.0 0.6 0.0043 15.3 0.6 1.3 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA Apolipoprotein PF01442.18 EMD65821.1 - 0.0045 16.9 0.8 0.0055 16.6 0.8 1.1 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain Spectrin PF00435.21 EMD65821.1 - 0.0083 16.6 1.8 0.012 16.1 1.8 1.2 1 0 0 1 1 1 1 Spectrin repeat Sec34 PF04136.15 EMD65821.1 - 0.011 15.6 1.2 0.019 14.9 1.1 1.5 1 1 0 1 1 1 0 Sec34-like family DUF1451 PF07295.11 EMD65821.1 - 0.017 15.1 1.0 0.024 14.7 1.0 1.2 1 0 0 1 1 1 0 Zinc-ribbon containing domain Syntaxin-6_N PF09177.11 EMD65821.1 - 0.026 15.1 1.1 0.041 14.4 1.1 1.4 1 1 0 1 1 1 0 Syntaxin 6, N-terminal BLOC1_2 PF10046.9 EMD65821.1 - 0.032 14.5 0.8 0.032 14.5 0.8 1.6 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Allexi_40kDa PF05549.11 EMD65821.1 - 0.054 13.0 1.3 0.074 12.6 1.3 1.1 1 0 0 1 1 1 0 Allexivirus 40kDa protein CHDCT2 PF08074.11 EMD65821.1 - 0.056 13.6 0.0 0.071 13.3 0.0 1.3 1 0 0 1 1 1 0 CHDCT2 (NUC038) domain ISG65-75 PF11727.8 EMD65821.1 - 0.091 12.0 0.5 0.11 11.7 0.5 1.1 1 0 0 1 1 1 0 Invariant surface glycoprotein Cep57_MT_bd PF06657.13 EMD65821.1 - 0.2 12.1 3.3 0.22 12.0 0.6 2.2 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 CUT PF02376.15 EMD65822.1 - 0.0063 16.7 0.0 0.012 15.7 0.0 1.7 1 1 0 1 1 1 1 CUT domain LPP PF04728.13 EMD65822.1 - 0.012 16.0 4.9 0.17 12.3 0.2 2.8 2 1 0 2 2 2 0 Lipoprotein leucine-zipper Spc7 PF08317.11 EMD65822.1 - 0.015 14.2 15.3 0.22 10.4 1.7 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein Noelin-1 PF12308.8 EMD65822.1 - 0.015 15.2 1.5 0.015 15.2 1.5 1.7 2 0 0 2 2 2 0 Neurogenesis glycoprotein HIP1_clath_bdg PF16515.5 EMD65822.1 - 0.021 15.4 18.9 0.3 11.7 5.8 2.2 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 BLOC1_2 PF10046.9 EMD65822.1 - 0.17 12.2 9.2 0.16 12.3 1.8 2.4 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Vps54_N PF10475.9 EMD65822.1 - 0.27 10.5 10.6 0.87 8.8 10.3 1.7 1 1 1 2 2 2 0 Vacuolar-sorting protein 54, of GARP complex TMF_DNA_bd PF12329.8 EMD65822.1 - 0.29 11.2 11.1 0.34 10.9 1.5 3.0 2 2 1 3 3 3 0 TATA element modulatory factor 1 DNA binding BST2 PF16716.5 EMD65822.1 - 0.3 11.7 10.9 0.99 10.0 1.0 2.8 2 2 0 2 2 2 0 Bone marrow stromal antigen 2 Laminin_II PF06009.12 EMD65822.1 - 0.52 10.3 8.7 0.22 11.5 0.7 2.4 2 1 0 2 2 2 0 Laminin Domain II DUF1366 PF07104.11 EMD65822.1 - 0.93 9.2 9.5 0.44 10.2 1.7 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1366) UPF0449 PF15136.6 EMD65822.1 - 0.97 9.9 8.2 0.16 12.4 3.6 2.0 1 1 1 2 2 2 0 Uncharacterised protein family UPF0449 DivIC PF04977.15 EMD65822.1 - 1.2 9.0 10.6 0.81 9.5 1.1 2.8 2 1 1 3 3 3 0 Septum formation initiator GrpE PF01025.19 EMD65822.1 - 1.3 8.7 13.5 4 7.1 1.8 2.2 1 1 1 2 2 2 0 GrpE Sec34 PF04136.15 EMD65822.1 - 2.8 7.8 10.7 2.8 7.8 2.9 2.3 2 0 0 2 2 2 0 Sec34-like family Cnn_1N PF07989.11 EMD65822.1 - 3.4 7.9 11.0 0.49 10.6 1.0 2.9 2 2 0 2 2 2 0 Centrosomin N-terminal motif 1 YabA PF06156.13 EMD65822.1 - 7.1 7.3 9.7 2.1 9.0 1.8 2.3 2 0 0 2 2 2 0 Initiation control protein YabA Fib_alpha PF08702.10 EMD65822.1 - 7.3 6.8 10.7 0.55 10.4 4.0 2.0 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family AIG1 PF04548.16 EMD65824.1 - 0.011 15.0 0.1 0.02 14.2 0.1 1.3 1 0 0 1 1 1 0 AIG1 family Imm47 PF15573.6 EMD65824.1 - 0.079 12.5 0.0 2.5 7.5 0.0 2.0 1 1 1 2 2 2 0 Immunity protein 47 Chalcone PF02431.15 EMD65824.1 - 0.11 11.9 0.0 0.15 11.4 0.0 1.2 1 0 0 1 1 1 0 Chalcone-flavanone isomerase NAD_binding_6 PF08030.12 EMD65825.1 - 7.4e-08 32.7 0.0 1.9e-07 31.3 0.0 1.7 1 1 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EMD65825.1 - 0.059 13.5 0.0 0.11 12.6 0.0 1.4 1 0 0 1 1 1 0 FAD-binding domain TPR_19 PF14559.6 EMD65826.1 - 9.5e-07 29.2 0.2 0.0019 18.7 0.2 3.3 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 EMD65826.1 - 3.1e-05 23.7 0.1 0.063 13.3 0.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat F-box-like PF12937.7 EMD65826.1 - 8.2e-05 22.4 0.0 0.0002 21.2 0.0 1.7 1 0 0 1 1 1 1 F-box-like TPR_14 PF13428.6 EMD65826.1 - 0.00011 22.7 0.6 0.016 16.0 0.0 3.1 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 EMD65826.1 - 0.00048 20.4 0.2 0.0025 18.0 0.0 2.2 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_10 PF13374.6 EMD65826.1 - 0.0049 16.7 1.1 0.29 11.1 0.1 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 EMD65826.1 - 0.007 16.5 1.5 0.69 10.3 0.0 3.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 EMD65826.1 - 0.012 16.2 0.6 0.63 10.8 0.1 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF309 PF03745.14 EMD65826.1 - 0.013 15.2 1.4 0.7 9.6 0.0 3.0 2 1 2 4 4 4 0 Domain of unknown function (DUF309) TPR_2 PF07719.17 EMD65826.1 - 0.019 15.0 1.2 2 8.7 0.0 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat Clathrin PF00637.20 EMD65826.1 - 0.02 14.8 0.0 3 7.7 0.0 2.5 2 1 0 2 2 2 0 Region in Clathrin and VPS TPR_1 PF00515.28 EMD65826.1 - 0.035 13.9 0.1 1.7 8.6 0.0 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_20 PF14561.6 EMD65826.1 - 0.064 13.6 0.1 2.2 8.7 0.0 2.7 2 1 1 3 3 3 0 Tetratricopeptide repeat DUF1996 PF09362.10 EMD65827.1 - 1.3e-41 143.1 0.0 2.7e-41 142.1 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1996) ABC_tran_CTD PF16326.5 EMD65827.1 - 0.38 11.0 6.5 1.3 9.4 6.5 1.8 1 0 0 1 1 1 0 ABC transporter C-terminal domain DDE_3 PF13358.6 EMD65828.1 - 7.7e-08 32.2 0.5 1.7e-07 31.1 0.2 1.6 2 0 0 2 2 2 1 DDE superfamily endonuclease zf-C2H2 PF00096.26 EMD65832.1 - 8.3e-06 26.0 1.7 0.0019 18.5 0.3 4.8 5 0 0 5 5 5 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMD65832.1 - 3.1e-05 24.4 19.5 0.015 16.1 0.4 5.2 5 0 0 5 5 5 2 C2H2-type zinc finger zf-C2H2_2 PF12756.7 EMD65832.1 - 0.0017 18.6 4.0 2.3 8.6 0.1 3.4 1 1 2 3 3 3 2 C2H2 type zinc-finger (2 copies) Zn-ribbon_8 PF09723.10 EMD65832.1 - 0.059 13.5 0.2 0.059 13.5 0.2 2.5 3 0 0 3 3 3 0 Zinc ribbon domain zf-C2H2_6 PF13912.6 EMD65832.1 - 0.09 12.8 0.3 0.09 12.8 0.3 3.9 4 0 0 4 4 4 0 C2H2-type zinc finger zf-met PF12874.7 EMD65832.1 - 0.14 12.5 1.8 1.9 9.0 0.1 3.3 4 0 0 4 4 4 0 Zinc-finger of C2H2 type zinc_ribbon_5 PF13719.6 EMD65832.1 - 0.25 11.1 0.3 0.25 11.1 0.3 2.3 3 0 0 3 3 3 0 zinc-ribbon domain zf-H2C2_2 PF13465.6 EMD65832.1 - 7.5 7.2 14.1 4.3 7.9 1.0 3.4 3 0 0 3 3 3 0 Zinc-finger double domain APH PF01636.23 EMD65833.1 - 1.7e-12 47.8 0.0 2.4e-12 47.3 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EMD65833.1 - 0.0015 18.1 0.0 0.0025 17.5 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase Pkinase PF00069.25 EMD65833.1 - 0.01 15.2 0.0 0.026 13.9 0.0 1.7 2 0 0 2 2 2 0 Protein kinase domain Pox_ser-thr_kin PF05445.11 EMD65833.1 - 0.11 11.5 0.0 0.16 10.9 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Pkinase_Tyr PF07714.17 EMD65833.1 - 0.11 11.8 0.0 0.16 11.2 0.0 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase Haspin_kinase PF12330.8 EMD65833.1 - 0.26 10.2 0.0 0.39 9.6 0.0 1.1 1 0 0 1 1 1 0 Haspin like kinase domain DUF5344 PF17279.2 EMD65834.1 - 0.045 14.3 0.5 0.08 13.5 0.2 1.5 1 1 0 1 1 1 0 Family of unknown function (DUF5344) SERTA PF06031.13 EMD65835.1 - 0.0032 17.1 0.0 0.0078 15.9 0.0 1.6 1 0 0 1 1 1 1 SERTA motif HLH PF00010.26 EMD65836.1 - 7.4e-11 41.8 0.0 1.6e-10 40.8 0.0 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Endosulfine PF04667.17 EMD65836.1 - 0.0039 17.3 0.0 0.015 15.4 0.0 2.0 2 0 0 2 2 2 1 cAMP-regulated phosphoprotein/endosulfine conserved region TauD PF02668.16 EMD65837.1 - 2.2e-22 80.1 0.0 3.4e-22 79.5 0.0 1.3 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Fungal_trans PF04082.18 EMD65839.1 - 5.7e-09 35.4 0.2 1.4e-08 34.1 0.2 1.7 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD65839.1 - 2.9e-07 30.5 14.2 5.8e-07 29.5 14.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF1844 PF08899.11 EMD65839.1 - 0.026 14.8 2.2 0.026 14.8 0.6 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1844) CheY-binding PF09078.11 EMD65839.1 - 0.1 12.8 1.2 0.13 12.4 0.1 1.7 2 0 0 2 2 2 0 CheY binding Endosulfine PF04667.17 EMD65840.1 - 3e-15 56.1 0.0 5.4e-15 55.3 0.0 1.4 1 0 0 1 1 1 1 cAMP-regulated phosphoprotein/endosulfine conserved region Tubulin PF00091.25 EMD65841.1 - 8.8e-70 234.9 0.1 2.3e-68 230.3 0.0 2.1 2 0 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EMD65841.1 - 3.5e-43 146.8 0.2 5.7e-43 146.1 0.2 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 EMD65841.1 - 3.1e-05 24.3 0.0 7.9e-05 23.0 0.0 1.7 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_2 PF13809.6 EMD65841.1 - 0.0016 17.7 0.0 0.026 13.7 0.0 2.1 2 0 0 2 2 2 1 Tubulin like Tubulin_3 PF14881.6 EMD65841.1 - 0.0067 16.1 0.0 0.013 15.1 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain HLH PF00010.26 EMD65844.1 - 2.2e-11 43.5 0.0 3.9e-11 42.7 0.0 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain HSP20 PF00011.21 EMD65845.1 - 4.9e-09 36.3 0.0 1.1e-06 28.8 0.0 2.1 1 1 1 2 2 2 2 Hsp20/alpha crystallin family SecB PF02556.14 EMD65845.1 - 0.13 12.1 0.0 0.29 11.0 0.0 1.5 1 1 1 2 2 2 0 Preprotein translocase subunit SecB HLH PF00010.26 EMD65846.1 - 2e-10 40.5 0.0 3.7e-10 39.6 0.0 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain XFP_N PF09364.10 EMD65848.1 - 1.3e-173 576.9 0.0 1.7e-173 576.5 0.0 1.1 1 0 0 1 1 1 1 XFP N-terminal domain XFP PF03894.15 EMD65848.1 - 1.8e-82 275.3 0.0 3.5e-82 274.4 0.0 1.5 1 0 0 1 1 1 1 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase XFP_C PF09363.10 EMD65848.1 - 2.7e-82 275.1 0.0 4.1e-82 274.5 0.0 1.3 1 0 0 1 1 1 1 XFP C-terminal domain DUF5333 PF17267.2 EMD65848.1 - 0.15 12.2 0.0 0.32 11.2 0.0 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5333) p450 PF00067.22 EMD65849.1 - 1.7e-20 73.2 0.0 8.9e-18 64.3 0.0 2.6 2 1 1 3 3 3 2 Cytochrome P450 HSP20 PF00011.21 EMD65850.1 - 6.3e-06 26.3 0.0 0.00047 20.3 0.0 2.2 2 0 0 2 2 2 2 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 EMD65850.1 - 0.046 13.3 0.0 0.13 11.9 0.0 1.7 1 1 0 1 1 1 0 HSP20-like domain found in ArsA TAL_FSA PF00923.19 EMD65851.1 - 5.8e-74 249.0 0.1 3.6e-73 246.4 0.1 1.8 1 1 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase Ecl1 PF12855.7 EMD65852.1 - 1.6e-23 84.7 18.2 1.6e-23 84.7 18.2 1.9 2 0 0 2 2 2 1 ECL1/2/3 zinc binding proteins HTH_Tnp_Tc5 PF03221.16 EMD65853.1 - 8e-07 29.0 0.1 3.6e-06 26.9 0.1 2.1 1 1 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EMD65853.1 - 1.2e-06 28.2 0.2 1.8e-06 27.6 0.2 1.4 1 0 0 1 1 1 1 helix-turn-helix, Psq domain CENP-B_N PF04218.13 EMD65853.1 - 0.015 15.0 0.1 0.9 9.2 0.0 2.3 2 0 0 2 2 2 0 CENP-B N-terminal DNA-binding domain HTH_28 PF13518.6 EMD65853.1 - 0.019 15.1 0.0 0.74 10.0 0.0 2.4 1 1 1 2 2 2 0 Helix-turn-helix domain BrkDBD PF09607.10 EMD65853.1 - 0.023 14.5 0.1 0.043 13.6 0.1 1.5 1 0 0 1 1 1 0 Brinker DNA-binding domain DDE_1 PF03184.19 EMD65854.1 - 1.9e-17 63.5 0.0 2.1e-17 63.3 0.0 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.6 EMD65854.1 - 0.0017 18.1 0.0 0.23 11.2 0.0 2.1 1 1 1 2 2 2 2 DDE superfamily endonuclease DUF948 PF06103.11 EMD65855.1 - 0.0054 17.0 3.1 0.011 15.9 3.1 1.5 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF948) RasGAP_C PF03836.15 EMD65855.1 - 0.011 15.9 1.5 0.011 15.9 1.5 1.6 2 0 0 2 2 2 0 RasGAP C-terminus YabA PF06156.13 EMD65855.1 - 0.018 15.7 0.6 0.034 14.8 0.6 1.6 1 0 0 1 1 1 0 Initiation control protein YabA FlgN PF05130.12 EMD65855.1 - 0.036 14.6 5.7 0.06 13.9 5.5 1.5 1 1 0 1 1 1 0 FlgN protein AAA_13 PF13166.6 EMD65855.1 - 0.052 12.2 4.4 0.061 12.0 4.4 1.1 1 0 0 1 1 1 0 AAA domain Cauli_AT PF03233.13 EMD65855.1 - 0.16 11.9 3.1 0.25 11.3 3.1 1.3 1 0 0 1 1 1 0 Aphid transmission protein RuBisCO_large_N PF02788.16 EMD65855.1 - 0.29 11.3 2.2 1.5 9.0 0.6 2.1 1 1 1 2 2 2 0 Ribulose bisphosphate carboxylase large chain, N-terminal domain ZapB PF06005.12 EMD65855.1 - 0.38 11.2 7.0 1.5 9.4 0.0 2.6 1 1 1 2 2 2 0 Cell division protein ZapB SlyX PF04102.12 EMD65855.1 - 0.94 10.1 5.5 3.7 8.2 4.5 2.3 1 1 1 2 2 2 0 SlyX DivIC PF04977.15 EMD65855.1 - 1.5 8.7 8.1 3 7.7 0.8 2.5 1 1 1 2 2 2 0 Septum formation initiator TPR_10 PF13374.6 EMD65856.1 - 3.7e-37 125.2 3.6 1.2e-10 40.9 0.0 5.1 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_12 PF13424.6 EMD65856.1 - 2.4e-33 114.3 6.9 4.7e-16 58.8 0.1 4.8 2 2 3 5 5 5 5 Tetratricopeptide repeat TPR_7 PF13176.6 EMD65856.1 - 2.7e-10 39.5 0.2 0.4 10.8 0.0 4.5 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_1 PF00515.28 EMD65856.1 - 7.1e-09 35.1 1.7 0.17 11.7 0.9 4.5 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.6 EMD65856.1 - 1.2e-05 25.3 1.3 2.7 8.6 0.3 4.8 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_8 PF13181.6 EMD65856.1 - 2.7e-05 24.0 0.7 0.42 11.0 0.2 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat Phosphatase PF15698.5 EMD65856.1 - 0.014 14.6 0.2 0.23 10.6 0.0 2.4 1 1 0 2 2 2 0 Phosphatase TPR_2 PF07719.17 EMD65856.1 - 0.056 13.6 5.7 29 5.1 0.2 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat DALR_2 PF09190.11 EMD65856.1 - 0.1 13.1 0.8 3.6 8.1 0.4 2.7 1 1 1 2 2 2 0 DALR domain DDE_3 PF13358.6 EMD65857.1 - 0.1 12.3 0.0 0.12 12.1 0.0 1.1 1 0 0 1 1 1 0 DDE superfamily endonuclease HMG_box PF00505.19 EMD65858.1 - 3.4e-13 49.8 0.0 8.7e-13 48.5 0.0 1.7 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EMD65858.1 - 3.4e-09 37.2 0.0 9.6e-09 35.7 0.0 1.8 1 0 0 1 1 1 1 HMG-box domain SAM_1 PF00536.30 EMD65858.1 - 1.2e-08 35.3 0.0 2.1e-08 34.4 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 EMD65858.1 - 0.00023 21.2 0.0 0.00056 20.0 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Pkinase_fungal PF17667.1 EMD65859.1 - 9e-115 383.7 0.0 5.6e-114 381.1 0.0 1.9 1 1 0 1 1 1 1 Fungal protein kinase Pkinase PF00069.25 EMD65859.1 - 0.00064 19.2 0.0 0.001 18.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain MauJ PF17419.2 EMD65859.1 - 0.076 12.5 0.0 0.13 11.7 0.0 1.2 1 0 0 1 1 1 0 Methylamine utilization protein MauJ DUF3435 PF11917.8 EMD65860.1 - 4.9e-73 246.5 0.0 7.1e-73 245.9 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3435) Tnp_DNA_bind PF14706.6 EMD65860.1 - 0.059 13.2 0.1 0.15 11.9 0.1 1.7 1 0 0 1 1 1 0 Transposase DNA-binding BTB PF00651.31 EMD65862.1 - 2e-11 44.1 0.3 3.7e-11 43.2 0.3 1.4 1 0 0 1 1 1 1 BTB/POZ domain DUF3199 PF11436.8 EMD65862.1 - 0.15 12.1 0.0 0.25 11.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3199) DUF2232 PF09991.9 EMD65864.1 - 1.5 7.9 8.0 1.6 7.8 8.0 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) zf-C2H2 PF00096.26 EMD65865.1 - 1e-11 44.6 43.4 0.0037 17.6 1.4 9.0 7 2 2 9 9 9 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMD65865.1 - 6.2e-11 42.2 43.1 0.019 15.8 0.9 9.7 9 1 1 10 10 10 5 C2H2-type zinc finger zf-C2H2_2 PF12756.7 EMD65865.1 - 9.2e-06 25.9 29.1 0.087 13.2 0.3 6.0 2 1 2 5 5 5 4 C2H2 type zinc-finger (2 copies) zf-met PF12874.7 EMD65865.1 - 6.1e-05 23.3 26.4 0.15 12.5 0.2 7.7 7 1 0 7 7 7 3 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EMD65865.1 - 6.4e-05 23.1 37.2 0.03 14.6 1.3 7.1 7 2 1 8 8 8 4 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 EMD65865.1 - 0.0091 16.0 30.4 0.22 11.6 0.7 6.9 7 0 0 7 7 7 4 C2H2-type zinc finger Ank_2 PF12796.7 EMD65866.1 - 2.5e-27 95.3 4.2 2.3e-13 50.5 0.2 3.1 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMD65866.1 - 1e-23 83.4 4.3 6.8e-10 39.3 0.1 3.9 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 EMD65866.1 - 2.8e-16 59.1 4.4 0.00092 19.6 0.1 5.5 6 0 0 6 6 6 3 Ankyrin repeat Ank_3 PF13606.6 EMD65866.1 - 1.4e-12 46.6 0.1 0.26 12.0 0.0 5.5 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 EMD65866.1 - 1.5e-10 41.1 0.7 0.00065 20.0 0.1 4.6 1 1 4 5 5 5 4 Ankyrin repeats (many copies) DUF1843 PF08898.10 EMD65866.1 - 2.2 8.9 5.5 0.79 10.3 0.7 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1843) DUF3435 PF11917.8 EMD65867.1 - 5.9e-146 486.7 0.1 7.9e-146 486.2 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3435) zf-RING_2 PF13639.6 EMD65868.1 - 2.2e-12 47.1 4.9 3.8e-12 46.3 4.9 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EMD65868.1 - 5.1e-09 35.8 4.1 8.3e-09 35.1 4.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EMD65868.1 - 1.5e-08 34.8 2.8 3e-08 33.8 2.8 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 EMD65868.1 - 1.5e-08 34.4 2.6 2.5e-08 33.6 2.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EMD65868.1 - 4.4e-08 32.7 2.4 4.4e-08 32.7 2.4 1.9 2 0 0 2 2 2 1 RING-like zinc finger PA PF02225.22 EMD65868.1 - 3.9e-07 30.0 0.0 9.6e-07 28.7 0.0 1.7 1 0 0 1 1 1 1 PA domain zf-RING_5 PF14634.6 EMD65868.1 - 4.9e-07 29.6 1.9 7.6e-07 29.0 1.9 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EMD65868.1 - 6.4e-06 26.1 1.9 1.4e-05 25.0 0.4 2.2 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EMD65868.1 - 9.1e-06 25.4 2.8 1.4e-05 24.9 2.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EMD65868.1 - 0.0012 18.9 0.6 0.0022 18.0 0.6 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 EMD65868.1 - 0.0068 16.3 3.1 0.012 15.4 3.1 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 Zn_ribbon_17 PF17120.5 EMD65868.1 - 0.017 14.8 3.1 0.032 13.9 3.1 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type FANCL_C PF11793.8 EMD65868.1 - 0.15 12.3 2.4 0.38 11.0 2.4 1.7 1 1 0 1 1 1 0 FANCL C-terminal domain zf-C3HC4_4 PF15227.6 EMD65868.1 - 0.21 11.8 4.3 0.43 10.8 4.3 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING RINGv PF12906.7 EMD65868.1 - 0.44 10.7 2.4 0.95 9.6 2.3 1.7 1 1 0 1 1 1 0 RING-variant domain zf-RING_4 PF14570.6 EMD65868.1 - 1.3 8.9 2.7 2.7 7.9 2.7 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Baculo_VP1054 PF05789.11 EMD65869.1 - 1.7 7.7 11.3 0.91 8.7 1.4 2.1 2 0 0 2 2 2 0 Baculovirus VP1054 protein WD40 PF00400.32 EMD65870.1 - 8.3e-25 86.6 7.4 0.00039 21.2 0.0 6.5 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD65870.1 - 1e-13 51.4 6.6 3.2e-05 24.1 0.4 4.1 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EMD65870.1 - 3e-08 33.8 1.4 0.013 15.3 0.1 3.2 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Peptidase_M18 PF02127.15 EMD65871.1 - 8.9e-172 571.7 0.0 1.1e-171 571.4 0.0 1.1 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.14 EMD65871.1 - 0.024 13.7 0.0 8 5.4 0.1 3.2 2 1 1 3 3 3 0 M42 glutamyl aminopeptidase Hydrolase_6 PF13344.6 EMD65872.1 - 5e-30 103.6 0.0 9.7e-30 102.7 0.0 1.5 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EMD65872.1 - 7.3e-14 51.6 0.0 1.6e-13 50.5 0.0 1.6 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 EMD65872.1 - 1.1e-11 45.4 0.1 1.7e-05 25.2 0.0 3.0 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EMD65872.1 - 1.7e-05 25.0 0.1 0.2 11.7 0.0 2.5 2 1 1 3 3 3 2 Haloacid dehalogenase-like hydrolase DNA_primase_lrg PF04104.14 EMD65873.1 - 5.2e-85 285.1 0.0 1.3e-84 283.7 0.0 1.7 2 0 0 2 2 2 1 Eukaryotic and archaeal DNA primase, large subunit ArdA PF07275.11 EMD65873.1 - 0.15 12.6 0.6 0.51 10.9 0.1 2.1 2 0 0 2 2 2 0 Antirestriction protein (ArdA) F_bP_aldolase PF01116.20 EMD65874.1 - 1.1e-78 264.5 0.4 1.3e-78 264.3 0.4 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II AsiA PF09010.10 EMD65874.1 - 0.092 12.9 0.0 0.2 11.8 0.0 1.6 1 0 0 1 1 1 0 Anti-Sigma Factor A MIP PF00230.20 EMD65875.1 - 5.9e-54 183.2 17.4 7.6e-54 182.8 17.4 1.1 1 0 0 1 1 1 1 Major intrinsic protein MutS_V PF00488.21 EMD65876.1 - 3.3e-67 226.2 0.1 6.7e-67 225.2 0.1 1.5 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 EMD65876.1 - 1.2e-42 146.3 0.2 2.4e-42 145.3 0.2 1.5 1 0 0 1 1 1 1 MutS domain III MutS_I PF01624.20 EMD65876.1 - 5.3e-33 113.6 0.1 2.1e-32 111.7 0.0 2.1 2 0 0 2 2 2 1 MutS domain I MutS_II PF05188.17 EMD65876.1 - 1.6e-14 54.4 0.0 4.4e-14 52.9 0.0 1.8 1 0 0 1 1 1 1 MutS domain II MutS_IV PF05190.18 EMD65876.1 - 4.5e-11 42.9 0.3 1e-10 41.8 0.3 1.7 1 0 0 1 1 1 1 MutS family domain IV AAA_23 PF13476.6 EMD65876.1 - 0.0047 17.4 1.7 0.034 14.7 0.1 2.9 3 0 0 3 3 3 1 AAA domain AAA_29 PF13555.6 EMD65876.1 - 0.029 14.1 0.1 0.075 12.8 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_27 PF13514.6 EMD65876.1 - 0.065 12.8 0.0 0.14 11.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain Myosin_tail_1 PF01576.19 EMD65876.1 - 0.29 8.9 3.0 0.63 7.8 0.6 2.1 2 0 0 2 2 2 0 Myosin tail AAA_21 PF13304.6 EMD65876.1 - 0.41 10.4 1.4 0.59 9.9 0.1 1.9 2 1 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system ORC6 PF05460.13 EMD65877.1 - 0.0034 16.7 1.3 0.0044 16.4 1.3 1.1 1 0 0 1 1 1 1 Origin recognition complex subunit 6 (ORC6) Pox_Ag35 PF03286.14 EMD65877.1 - 0.33 10.7 3.9 0.42 10.4 3.9 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein PIG-U PF06728.13 EMD65878.1 - 7.6e-117 390.6 29.0 8.7e-117 390.4 29.0 1.0 1 0 0 1 1 1 1 GPI transamidase subunit PIG-U 8TM_micro PF17028.5 EMD65878.1 - 0.68 9.6 7.8 2.7 7.6 7.8 1.9 1 1 0 1 1 1 0 8TM Microsporidial transmembrane domain Pescadillo_N PF06732.11 EMD65879.1 - 2e-124 414.5 0.0 2e-124 414.5 0.0 1.7 2 0 0 2 2 2 1 Pescadillo N-terminus BRCT_2 PF16589.5 EMD65879.1 - 8.5e-05 22.9 0.0 0.00044 20.6 0.0 2.2 1 1 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 EMD65879.1 - 0.00025 21.4 0.0 0.002 18.5 0.0 2.3 1 1 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain LIG3_BRCT PF16759.5 EMD65879.1 - 0.028 14.7 0.9 0.26 11.6 0.9 2.3 1 1 0 1 1 1 0 DNA ligase 3 BRCT domain TPR_20 PF14561.6 EMD65879.1 - 6.4 7.2 12.2 2.3 8.6 4.2 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat MFS_1 PF07690.16 EMD65880.1 - 1.7e-24 86.5 23.4 1.7e-24 86.5 23.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EMD65880.1 - 0.0023 16.4 0.5 0.0035 15.8 0.5 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Zip PF02535.22 EMD65882.1 - 2.3e-56 191.5 0.2 3.5e-56 190.8 0.2 1.3 1 1 0 1 1 1 1 ZIP Zinc transporter RseC_MucC PF04246.12 EMD65882.1 - 0.12 12.4 1.3 0.29 11.1 0.0 2.3 2 0 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC Mur_ligase_M PF08245.12 EMD65883.1 - 7.4e-07 29.3 0.3 1.4e-05 25.2 0.1 2.8 1 1 1 2 2 2 1 Mur ligase middle domain Ogr_Delta PF04606.12 EMD65884.1 - 0.11 12.5 0.3 0.29 11.1 0.3 1.8 1 0 0 1 1 1 0 Ogr/Delta-like zinc finger HTH_Tnp_Tc3_2 PF01498.18 EMD65885.1 - 2.9e-22 78.7 0.1 5e-22 77.9 0.1 1.4 1 0 0 1 1 1 1 Transposase HTH_32 PF13565.6 EMD65885.1 - 1.5e-07 32.0 2.4 2.7e-05 24.7 0.1 2.6 2 1 1 3 3 3 2 Homeodomain-like domain HTH_23 PF13384.6 EMD65885.1 - 7.1e-06 25.7 0.2 0.0018 18.0 0.0 2.5 2 0 0 2 2 2 1 Homeodomain-like domain HTH_33 PF13592.6 EMD65885.1 - 3.3e-05 23.4 0.1 8.2e-05 22.2 0.1 1.6 1 0 0 1 1 1 1 Winged helix-turn helix HTH_Tnp_ISL3 PF13542.6 EMD65885.1 - 0.0011 18.3 1.7 0.79 9.2 0.0 2.8 3 0 0 3 3 3 2 Helix-turn-helix domain of transposase family ISL3 HTH_21 PF13276.6 EMD65885.1 - 0.0068 16.5 0.1 0.024 14.7 0.0 1.8 2 0 0 2 2 2 1 HTH-like domain DDE_Tnp_ISAZ013 PF07592.11 EMD65885.1 - 0.0086 15.1 0.0 0.019 13.9 0.0 1.6 1 1 1 2 2 2 1 Rhodopirellula transposase DDE domain HTH_29 PF13551.6 EMD65885.1 - 0.049 13.7 0.0 0.14 12.2 0.0 1.9 1 1 0 1 1 1 0 Winged helix-turn helix Sigma70_r4_2 PF08281.12 EMD65885.1 - 0.078 12.7 0.1 0.19 11.4 0.0 1.7 2 0 0 2 2 2 0 Sigma-70, region 4 UB2H PF14814.6 EMD65885.1 - 0.1 12.7 0.0 0.17 11.9 0.0 1.4 1 0 0 1 1 1 0 Bifunctional transglycosylase second domain FKBP_C PF00254.28 EMD65886.1 - 6.6e-32 109.7 0.0 8e-32 109.4 0.0 1.1 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Cation_ATPase_C PF00689.21 EMD65888.1 - 9.3e-43 146.0 6.6 9.3e-43 146.0 6.6 2.4 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 EMD65888.1 - 2.5e-34 118.4 2.9 2.5e-34 118.4 2.9 3.0 4 0 0 4 4 4 1 E1-E2 ATPase Hydrolase PF00702.26 EMD65888.1 - 2.7e-19 70.3 1.0 9.5e-19 68.5 1.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EMD65888.1 - 6.7e-18 64.6 0.0 1.4e-17 63.5 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 EMD65888.1 - 7.6e-12 44.7 0.0 6.2e-10 38.6 0.0 2.6 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EMD65888.1 - 3e-06 27.2 0.2 7.5e-05 22.6 0.2 2.3 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase LptF_LptG PF03739.14 EMD65888.1 - 0.24 10.2 4.8 0.23 10.3 2.4 2.1 2 0 0 2 2 2 0 Lipopolysaccharide export system permease LptF/LptG zinc_ribbon_15 PF17032.5 EMD65890.1 - 0.0097 16.6 2.6 0.027 15.2 2.6 1.8 1 1 0 1 1 1 1 zinc-ribbon family Fer2_3 PF13085.6 EMD65890.1 - 0.17 11.9 4.5 0.33 11.0 4.5 1.4 1 0 0 1 1 1 0 2Fe-2S iron-sulfur cluster binding domain zf-B_box PF00643.24 EMD65890.1 - 0.79 9.9 11.3 0.16 12.2 3.7 2.8 2 1 1 3 3 3 0 B-box zinc finger C6_DPF PF10170.9 EMD65890.1 - 1.3 9.5 6.8 1.1 9.7 5.2 1.7 1 1 1 2 2 2 0 Cysteine-rich domain FYVE_2 PF02318.16 EMD65890.1 - 1.8 8.8 6.2 1 9.6 3.4 2.0 2 0 0 2 2 2 0 FYVE-type zinc finger Memo PF01875.17 EMD65891.1 - 4.4e-69 232.6 0.0 6.1e-69 232.2 0.0 1.2 1 0 0 1 1 1 1 Memo-like protein UvrD-helicase PF00580.21 EMD65892.1 - 2.7e-63 214.4 4.5 4.7e-62 210.3 1.7 2.6 2 1 0 2 2 2 1 UvrD/REP helicase N-terminal domain UvrD_C PF13361.6 EMD65892.1 - 3e-59 201.2 0.1 8e-57 193.2 0.0 2.4 2 0 0 2 2 2 2 UvrD-like helicase C-terminal domain AAA_19 PF13245.6 EMD65892.1 - 3.1e-32 111.9 0.0 2.3e-31 109.1 0.0 2.4 2 0 0 2 2 2 1 AAA domain UvrD_C_2 PF13538.6 EMD65892.1 - 4.5e-14 52.0 0.0 1.3e-13 50.5 0.0 1.9 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_30 PF13604.6 EMD65892.1 - 9.2e-09 35.3 0.0 1.9e-05 24.5 0.0 2.5 2 0 0 2 2 2 2 AAA domain Viral_helicase1 PF01443.18 EMD65892.1 - 2.7e-05 24.0 0.0 0.24 11.1 0.0 3.4 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase AAA_12 PF13087.6 EMD65892.1 - 0.015 14.9 0.0 0.045 13.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 EMD65892.1 - 0.056 13.2 0.0 0.056 13.2 0.0 3.7 4 0 0 4 4 4 0 AAA domain Cellulase PF00150.18 EMD65893.1 - 8.8e-11 41.8 4.7 4.4e-10 39.5 4.7 2.1 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Glyco_transf_28 PF03033.20 EMD65894.1 - 1.2e-17 64.2 0.0 4.2e-17 62.5 0.0 1.9 1 1 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain UDPGT PF00201.18 EMD65894.1 - 5.5e-05 22.1 0.0 8.7e-05 21.5 0.0 1.2 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 EMD65894.1 - 0.0016 18.4 0.0 0.003 17.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain SPARC_Ca_bdg PF10591.9 EMD65894.1 - 0.14 12.5 0.7 8.9 6.7 0.1 2.4 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region Metallophos PF00149.28 EMD65896.1 - 5.9e-35 121.6 0.1 8.6e-35 121.1 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EMD65896.1 - 6.9e-17 61.6 0.0 1.3e-16 60.8 0.0 1.5 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain Aldedh PF00171.22 EMD65898.1 - 9.6e-181 601.3 0.5 1.1e-180 601.1 0.5 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 EMD65898.1 - 0.037 13.5 0.0 1.2 8.5 0.0 2.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1487) DUF5133 PF17196.4 EMD65898.1 - 0.11 12.7 1.1 2.7 8.3 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF5133) Methyltransf_PK PF05891.12 EMD65899.1 - 9e-80 267.3 0.0 1e-79 267.1 0.0 1.0 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_25 PF13649.6 EMD65899.1 - 4.8e-06 27.2 0.0 1.8e-05 25.3 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EMD65899.1 - 0.0079 16.0 0.0 0.021 14.6 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMD65899.1 - 0.0099 16.5 0.0 0.04 14.6 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain TLP-20 PF06088.11 EMD65900.1 - 0.28 11.0 9.9 0.53 10.1 3.0 2.2 2 0 0 2 2 2 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) RNA_pol_Rpc4 PF05132.14 EMD65900.1 - 0.33 11.4 5.0 2.3 8.7 2.2 2.3 2 0 0 2 2 2 0 RNA polymerase III RPC4 Nop14 PF04147.12 EMD65900.1 - 0.68 8.1 18.9 0.95 7.6 18.9 1.2 1 0 0 1 1 1 0 Nop14-like family Radial_spoke PF04712.12 EMD65900.1 - 1.3 7.9 14.1 1.8 7.4 14.1 1.1 1 0 0 1 1 1 0 Radial spokehead-like protein BUD22 PF09073.10 EMD65900.1 - 4.9 6.4 19.9 7.3 5.8 19.9 1.2 1 0 0 1 1 1 0 BUD22 Prothymosin PF03247.14 EMD65900.1 - 7.6 7.0 31.6 3.9 8.0 20.6 2.3 2 0 0 2 2 2 0 Prothymosin/parathymosin family SDA1 PF05285.12 EMD65900.1 - 9.1 5.6 22.0 14 5.0 22.0 1.2 1 0 0 1 1 1 0 SDA1 Methyltransf_11 PF08241.12 EMD65901.1 - 0.011 16.4 0.0 0.025 15.2 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.6 EMD65901.1 - 0.087 13.5 0.0 0.19 12.4 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain DNA_binding_1 PF01035.20 EMD65902.1 - 1.9e-28 98.4 0.0 2.3e-28 98.1 0.0 1.1 1 0 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, DNA binding domain HTH_24 PF13412.6 EMD65902.1 - 0.19 11.3 0.0 0.42 10.2 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding TPR_17 PF13431.6 EMD65903.1 - 1.6e-06 28.1 1.0 0.054 13.9 0.2 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 EMD65903.1 - 0.0064 16.1 2.1 0.51 10.1 0.2 3.2 3 0 0 3 3 3 1 TPR repeat TPR_12 PF13424.6 EMD65903.1 - 0.0071 16.6 9.4 1.1 9.6 0.6 4.6 2 2 1 3 3 3 2 Tetratricopeptide repeat SPO22 PF08631.10 EMD65903.1 - 0.18 11.2 4.0 0.17 11.3 0.7 2.3 2 1 1 3 3 3 0 Meiosis protein SPO22/ZIP4 like VapB_antitoxin PF09957.9 EMD65903.1 - 0.19 11.7 1.5 6.8 6.7 0.0 3.3 2 1 1 3 3 3 0 Bacterial antitoxin of type II TA system, VapB TPR_1 PF00515.28 EMD65903.1 - 0.25 11.2 3.0 22 5.1 0.0 4.5 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_14 PF13428.6 EMD65903.1 - 1.1 10.3 11.2 0.39 11.7 0.5 4.8 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_10 PF13374.6 EMD65903.1 - 6.4 6.8 7.4 7.6 6.5 0.2 4.1 3 1 1 4 4 4 0 Tetratricopeptide repeat Ribophorin_II PF05817.14 EMD65904.1 - 7.2e-33 114.0 0.0 8e-33 113.9 0.0 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase subunit Ribophorin II PhoLip_ATPase_C PF16212.5 EMD65904.1 - 0.08 12.7 0.0 0.12 12.1 0.0 1.2 1 0 0 1 1 1 0 Phospholipid-translocating P-type ATPase C-terminal bZIP_2 PF07716.15 EMD65905.1 - 0.0032 17.5 8.1 0.0076 16.3 8.1 1.6 1 0 0 1 1 1 1 Basic region leucine zipper DUF1746 PF08508.10 EMD65909.1 - 3.9e-38 130.3 0.1 5.4e-38 129.9 0.1 1.2 1 0 0 1 1 1 1 Fungal domain of unknown function (DUF1746) HIG_1_N PF04588.13 EMD65910.1 - 1.6e-19 69.8 0.1 2.3e-19 69.4 0.1 1.2 1 0 0 1 1 1 1 Hypoxia induced protein conserved region LEA_4 PF02987.16 EMD65910.1 - 0.00072 19.6 4.6 0.0017 18.4 4.6 1.7 1 0 0 1 1 1 1 Late embryogenesis abundant protein TPX2 PF06886.11 EMD65910.1 - 9.9 6.5 19.3 34 4.8 19.2 2.0 1 1 0 1 1 1 0 Targeting protein for Xklp2 (TPX2) SGL PF08450.12 EMD65911.1 - 6e-68 229.1 0.0 7e-68 228.8 0.0 1.0 1 0 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region DUF5074 PF16819.5 EMD65911.1 - 0.08 13.0 0.0 1.6 8.8 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF5074) Lactonase PF10282.9 EMD65911.1 - 0.15 11.3 0.0 0.24 10.6 0.0 1.2 1 0 0 1 1 1 0 Lactonase, 7-bladed beta-propeller Fer2_2 PF01799.20 EMD65912.1 - 0.4 10.7 4.7 4.8 7.3 4.6 2.1 1 1 1 2 2 2 0 [2Fe-2S] binding domain BolA PF01722.18 EMD65913.1 - 6.5e-32 109.6 1.3 8e-32 109.4 1.3 1.1 1 0 0 1 1 1 1 BolA-like protein AMP-binding PF00501.28 EMD65914.1 - 5.5e-69 232.8 0.0 7.7e-69 232.3 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EMD65914.1 - 7.4e-13 49.3 0.1 1.6e-12 48.2 0.1 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Gpr1_Fun34_YaaH PF01184.19 EMD65915.1 - 7e-87 290.4 18.5 8.2e-87 290.1 18.5 1.0 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family AAA PF00004.29 EMD65916.1 - 5.6e-17 62.4 0.0 1.2e-16 61.4 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EMD65916.1 - 0.063 13.7 0.0 11 6.4 0.0 2.6 1 1 0 2 2 2 0 AAA ATPase domain FAA_hydrolase PF01557.18 EMD65917.1 - 1.7e-48 165.2 0.0 2.3e-48 164.7 0.0 1.2 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family FAA_hydrolase_N PF09298.11 EMD65917.1 - 3.8e-20 72.1 0.0 6.7e-20 71.3 0.0 1.4 1 0 0 1 1 1 1 Fumarylacetoacetase N-terminal QueC PF06508.13 EMD65917.1 - 0.031 13.8 0.0 0.053 13.0 0.0 1.4 1 0 0 1 1 1 0 Queuosine biosynthesis protein QueC Cupin_2 PF07883.11 EMD65918.1 - 2e-08 33.8 0.0 3.9e-08 32.9 0.0 1.5 1 0 0 1 1 1 1 Cupin domain Cupin_3 PF05899.12 EMD65918.1 - 0.014 15.1 0.0 0.026 14.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF861) PepX_C PF08530.10 EMD65919.1 - 1e-42 146.6 0.2 1.5e-42 146.1 0.2 1.2 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain Peptidase_S15 PF02129.18 EMD65919.1 - 7.2e-40 137.3 0.3 1.1e-39 136.7 0.3 1.2 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) LigB PF02900.18 EMD65920.1 - 1.9e-06 27.1 0.0 2.8e-06 26.6 0.0 1.3 1 1 0 1 1 1 1 Catalytic LigB subunit of aromatic ring-opening dioxygenase Fungal_trans PF04082.18 EMD65921.1 - 1.6e-11 43.8 3.1 2.7e-11 43.0 3.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 EMD65921.1 - 1.6e-10 40.8 6.8 6.9e-05 23.1 3.4 3.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type Zn_clus PF00172.18 EMD65921.1 - 9.3e-06 25.7 11.8 9.3e-06 25.7 11.8 2.1 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-C2H2_4 PF13894.6 EMD65921.1 - 1.7e-05 25.3 5.5 0.0018 18.9 0.1 3.7 5 0 0 5 5 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EMD65921.1 - 6.6e-05 23.2 1.7 6.6e-05 23.2 1.7 3.7 4 1 0 4 4 3 1 Zinc-finger double domain zf-Di19 PF05605.12 EMD65921.1 - 0.00094 19.4 1.6 0.00094 19.4 1.6 2.4 2 0 0 2 2 2 1 Drought induced 19 protein (Di19), zinc-binding zf-C2HC_2 PF13913.6 EMD65921.1 - 0.0012 18.7 2.6 0.019 14.9 0.6 2.9 2 0 0 2 2 2 1 zinc-finger of a C2HC-type zf-C2H2_jaz PF12171.8 EMD65921.1 - 0.0057 16.9 0.8 0.83 10.0 0.0 2.9 2 1 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EMD65921.1 - 0.02 15.3 4.9 0.81 10.2 0.5 3.2 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 EMD65921.1 - 0.029 14.4 13.3 0.27 11.3 1.9 3.2 4 0 0 4 4 3 0 C2H2-type zinc finger zf-C2H2_3rep PF18868.1 EMD65921.1 - 0.27 11.9 4.0 0.41 11.3 0.1 2.4 1 1 1 2 2 2 0 Zinc finger C2H2-type, 3 repeats zf-C2H2_11 PF16622.5 EMD65921.1 - 2.6 7.9 5.8 0.78 9.6 2.2 2.0 2 0 0 2 2 2 0 zinc-finger C2H2-type MFS_1 PF07690.16 EMD65922.1 - 8.4e-26 90.7 32.0 8.4e-26 90.7 32.0 2.2 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EMD65922.1 - 8.6e-12 44.6 1.2 8.6e-12 44.6 1.2 2.5 2 1 1 3 3 3 1 Sugar (and other) transporter TRI12 PF06609.13 EMD65922.1 - 7e-06 24.7 2.4 7e-06 24.7 2.4 1.7 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Aldedh PF00171.22 EMD65923.1 - 1.3e-10 40.4 0.0 3e-08 32.6 0.0 2.2 1 1 0 1 1 1 1 Aldehyde dehydrogenase family FAD_binding_3 PF01494.19 EMD65925.1 - 3.8e-21 75.7 0.0 9.4e-21 74.4 0.0 1.6 1 1 0 1 1 1 1 FAD binding domain ADC PF06314.11 EMD65925.1 - 1e-16 61.2 0.0 1.6e-16 60.6 0.0 1.3 1 0 0 1 1 1 1 Acetoacetate decarboxylase (ADC) Pyr_redox_2 PF07992.14 EMD65925.1 - 7e-09 35.3 0.1 1.3e-08 34.4 0.1 1.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EMD65925.1 - 3e-07 30.4 1.2 0.00014 21.5 0.6 2.2 1 1 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EMD65925.1 - 2.3e-05 24.5 0.5 5.6e-05 23.3 0.5 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EMD65925.1 - 0.00046 19.4 0.5 0.00082 18.6 0.5 1.4 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 EMD65925.1 - 0.012 15.0 0.2 0.019 14.3 0.2 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase Pyr_redox PF00070.27 EMD65925.1 - 0.04 14.5 0.2 0.35 11.4 0.2 2.4 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EMD65925.1 - 0.047 12.8 1.2 0.11 11.6 1.2 1.6 1 1 0 1 1 1 0 Glucose inhibited division protein A Amino_oxidase PF01593.24 EMD65925.1 - 0.12 11.6 0.1 0.23 10.7 0.1 1.5 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase HI0933_like PF03486.14 EMD65925.1 - 0.15 10.7 0.1 0.28 9.9 0.1 1.4 1 0 0 1 1 1 0 HI0933-like protein Mur_ligase PF01225.25 EMD65925.1 - 0.15 12.4 0.1 0.33 11.3 0.1 1.5 1 0 0 1 1 1 0 Mur ligase family, catalytic domain 3HCDH_N PF02737.18 EMD65925.1 - 0.21 11.4 0.1 0.37 10.7 0.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DUF1043 PF06295.12 EMD65926.1 - 0.025 14.6 1.8 0.5 10.4 1.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1043) DUF3456 PF11938.8 EMD65926.1 - 0.077 13.5 0.5 0.077 13.5 0.5 1.7 2 0 0 2 2 2 0 TLR4 regulator and MIR-interacting MSAP EF-hand_6 PF13405.6 EMD65928.1 - 8.8e-12 44.0 1.2 2e-05 24.2 0.0 2.8 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 EMD65928.1 - 2.4e-09 36.1 2.0 8e-05 21.9 0.2 2.3 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 EMD65928.1 - 1.7e-07 31.6 0.2 3.6e-07 30.5 0.2 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 EMD65928.1 - 1.6e-06 27.4 3.7 0.00023 20.5 0.8 2.3 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 EMD65928.1 - 9.3e-06 25.4 0.7 0.029 14.2 0.1 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_9 PF14658.6 EMD65928.1 - 1.4e-05 25.4 0.0 0.19 12.0 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain Afi1 PF07792.12 EMD65929.1 - 5.6e-44 149.8 1.2 5.6e-44 149.8 1.2 2.1 3 0 0 3 3 3 1 Docking domain of Afi1 for Arf3 in vesicle trafficking SPA PF08616.10 EMD65929.1 - 1.5e-37 128.0 0.0 6.5e-37 126.0 0.0 2.0 2 0 0 2 2 2 1 Stabilization of polarity axis Avl9 PF09794.9 EMD65929.1 - 1.8e-07 30.2 0.0 0.11 11.2 0.0 4.3 4 1 1 5 5 5 2 Transport protein Avl9 DUF2347 PF09804.9 EMD65929.1 - 0.0058 16.3 0.0 0.026 14.1 0.0 2.1 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2347) BUD22 PF09073.10 EMD65929.1 - 0.0065 15.9 4.0 0.011 15.1 4.0 1.3 1 0 0 1 1 1 1 BUD22 FAM104 PF15434.6 EMD65929.1 - 0.018 15.6 2.6 2.2 8.9 0.1 3.2 3 0 0 3 3 3 0 Family 104 Astro_capsid_p PF12226.8 EMD65929.1 - 0.03 13.5 5.5 0.052 12.7 5.5 1.3 1 0 0 1 1 1 0 Turkey astrovirus capsid protein SAPS PF04499.15 EMD65929.1 - 0.27 10.0 0.8 0.4 9.4 0.8 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein NPR3 PF03666.13 EMD65929.1 - 1.7 7.4 4.6 3.1 6.5 4.6 1.4 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 TRAP_alpha PF03896.16 EMD65929.1 - 2.3 7.4 4.7 4.6 6.4 4.7 1.4 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Cwf_Cwc_15 PF04889.12 EMD65929.1 - 4.9 6.8 23.4 0.25 11.0 17.7 1.6 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein RXT2_N PF08595.11 EMD65929.1 - 8.3 6.4 9.1 5.6 7.0 6.3 2.1 2 0 0 2 2 2 0 RXT2-like, N-terminal HeLo PF14479.6 EMD65930.1 - 1.1e-28 100.5 0.3 1.2e-28 100.4 0.3 1.0 1 0 0 1 1 1 1 Prion-inhibition and propagation ArabFuran-catal PF09206.11 EMD65932.1 - 3.1e-149 496.6 10.1 4.1e-149 496.1 10.1 1.2 1 0 0 1 1 1 1 Alpha-L-arabinofuranosidase B, catalytic AbfB PF05270.13 EMD65932.1 - 2e-51 173.7 1.3 2.9e-51 173.1 1.3 1.3 1 0 0 1 1 1 1 Alpha-L-arabinofuranosidase B (ABFB) domain Mitofilin PF09731.9 EMD65933.1 - 2.1e-132 443.1 29.3 1.3e-115 387.6 26.9 2.0 1 1 1 2 2 2 2 Mitochondrial inner membrane protein DIT1_PvcA PF05141.12 EMD65933.1 - 0.17 11.4 6.3 0.3 10.5 6.3 1.3 1 0 0 1 1 1 0 Pyoverdine/dityrosine biosynthesis protein ALMT PF11744.8 EMD65933.1 - 1.1 8.0 13.9 1.7 7.4 13.9 1.4 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF1515 PF07439.11 EMD65933.1 - 1.6 8.8 5.9 0.64 10.1 1.1 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF1515) DUF2756 PF10956.8 EMD65933.1 - 5.7 7.5 11.5 4.8 7.7 2.8 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2756) V-ATPase_G_2 PF16999.5 EMD65933.1 - 7.7 7.0 18.4 0.79 10.2 12.8 2.3 2 1 1 3 3 3 0 Vacuolar (H+)-ATPase G subunit Syja_N PF02383.18 EMD65935.1 - 4.9e-89 298.8 0.0 6.3e-89 298.5 0.0 1.1 1 0 0 1 1 1 1 SacI homology domain 7TMR-DISM_7TM PF07695.11 EMD65935.1 - 0.045 13.6 3.2 0.07 13.0 3.2 1.2 1 0 0 1 1 1 0 7TM diverse intracellular signalling DUF780 PF05611.11 EMD65935.1 - 0.31 11.8 2.7 0.75 10.6 2.7 1.6 1 0 0 1 1 1 0 Caenorhabditis elegans protein of unknown function (DUF780) Ras PF00071.22 EMD65936.1 - 2.9e-59 199.3 0.3 3.4e-59 199.1 0.3 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMD65936.1 - 2.4e-36 124.6 0.1 7.1e-36 123.1 0.1 1.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMD65936.1 - 4.9e-15 55.4 0.0 6e-15 55.1 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EMD65936.1 - 1.3e-06 28.4 0.0 2.2e-06 27.7 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EMD65936.1 - 1.5e-06 27.9 0.0 2.2e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EMD65936.1 - 2.2e-06 27.2 0.0 2.6e-06 27.0 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 EMD65936.1 - 7.5e-06 26.0 1.4 0.045 13.7 0.2 2.4 1 1 2 3 3 3 2 RsgA GTPase AAA_16 PF13191.6 EMD65936.1 - 0.0072 16.7 0.2 0.013 15.9 0.2 1.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EMD65936.1 - 0.11 12.7 0.0 3.1 8.1 0.0 2.3 1 1 1 2 2 2 0 AAA domain SRPRB PF09439.10 EMD65936.1 - 0.12 11.8 0.1 0.26 10.7 0.1 1.5 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit TniB PF05621.11 EMD65936.1 - 0.13 11.7 0.0 0.32 10.4 0.0 1.6 2 0 0 2 2 2 0 Bacterial TniB protein AAT PF03417.16 EMD65936.1 - 0.16 11.6 0.2 0.25 11.0 0.2 1.2 1 0 0 1 1 1 0 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase GbpA_2 PF18416.1 EMD65936.1 - 0.22 11.8 1.2 6 7.2 1.2 2.3 1 1 0 1 1 1 0 N-acetylglucosamine binding protein domain 2 Pro-kuma_activ PF09286.11 EMD65937.1 - 2.2e-41 141.5 0.1 4.1e-41 140.6 0.1 1.5 1 0 0 1 1 1 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 EMD65937.1 - 6.3e-05 22.4 0.0 0.00012 21.4 0.0 1.5 1 1 0 1 1 1 1 Subtilase family Na_Ca_ex PF01699.24 EMD65938.1 - 9.1e-27 93.9 25.2 6.7e-15 55.4 9.7 2.2 2 0 0 2 2 2 2 Sodium/calcium exchanger protein DUF3796 PF12676.7 EMD65938.1 - 0.13 12.7 5.6 0.067 13.6 1.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3796) CN_hydrolase PF00795.22 EMD65939.1 - 2.2e-41 141.9 0.0 3.7e-41 141.2 0.0 1.3 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Asp_Glu_race PF01177.22 EMD65939.1 - 6.7e-11 42.5 0.4 4.1e-10 39.9 0.1 2.1 2 0 0 2 2 2 1 Asp/Glu/Hydantoin racemase Aldo_ket_red PF00248.21 EMD65941.1 - 2e-54 184.8 0.0 2.3e-54 184.6 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Acetyltransf_10 PF13673.7 EMD65942.1 - 8.3e-09 35.5 0.0 1.6e-08 34.6 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EMD65942.1 - 0.00037 20.7 0.0 0.00057 20.1 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EMD65942.1 - 0.00055 20.3 0.0 0.0012 19.3 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Fringe PF02434.16 EMD65943.1 - 4.5e-08 32.8 0.4 2.1e-07 30.6 0.4 1.9 1 1 0 1 1 1 1 Fringe-like PAN_3 PF08277.12 EMD65943.1 - 0.0013 18.5 0.5 0.0026 17.6 0.5 1.4 1 0 0 1 1 1 1 PAN-like domain Galactosyl_T PF01762.21 EMD65943.1 - 0.025 14.4 0.0 0.1 12.4 0.0 1.8 1 1 1 2 2 2 0 Galactosyltransferase PAN_4 PF14295.6 EMD65943.1 - 0.087 12.8 0.4 0.25 11.3 0.4 1.7 1 0 0 1 1 1 0 PAN domain PAN_2 PF08276.11 EMD65943.1 - 0.11 12.6 1.3 0.24 11.5 1.3 1.5 1 0 0 1 1 1 0 PAN-like domain SPT16 PF08644.11 EMD65944.1 - 5.3e-54 182.5 0.2 5.3e-54 182.5 0.2 3.6 4 0 0 4 4 4 1 FACT complex subunit (SPT16/CDC68) FACT-Spt16_Nlob PF14826.6 EMD65944.1 - 3.2e-49 166.8 1.7 9.1e-49 165.4 0.6 2.5 2 0 0 2 2 2 1 FACT complex subunit SPT16 N-terminal lobe domain Peptidase_M24 PF00557.24 EMD65944.1 - 9.1e-27 94.1 0.0 1.7e-26 93.2 0.0 1.4 1 0 0 1 1 1 1 Metallopeptidase family M24 Rtt106 PF08512.12 EMD65944.1 - 4.1e-16 59.2 0.2 3e-15 56.4 0.0 2.3 2 0 0 2 2 2 1 Histone chaperone Rttp106-like Mito_carr PF00153.27 EMD65945.1 - 6e-15 54.9 1.7 2.1e-11 43.6 0.1 3.1 3 1 0 3 3 3 2 Mitochondrial carrier protein 2-Hacid_dh_C PF02826.19 EMD65946.1 - 6.1e-45 152.8 0.2 2.4e-43 147.5 0.2 2.1 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EMD65946.1 - 4.2e-06 26.4 0.0 1.1e-05 25.2 0.0 1.8 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain F420_oxidored PF03807.17 EMD65946.1 - 0.067 13.8 0.0 0.13 12.9 0.0 1.4 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 EMD65946.1 - 0.1 12.8 0.0 0.33 11.1 0.0 1.8 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase Goodbye PF17109.5 EMD65948.1 - 3.2e-06 27.6 0.0 3e-05 24.5 0.0 2.7 1 1 0 1 1 1 1 fungal STAND N-terminal Goodbye domain NACHT PF05729.12 EMD65948.1 - 5.3e-05 23.2 0.0 0.00015 21.7 0.0 1.8 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 EMD65948.1 - 0.0011 19.4 2.4 0.0022 18.4 0.0 2.8 4 0 0 4 4 4 1 AAA ATPase domain TPR_12 PF13424.6 EMD65948.1 - 0.0013 19.0 0.5 0.06 13.6 0.6 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat USP8_dimer PF08969.11 EMD65948.1 - 0.64 10.2 4.2 4.7 7.4 1.0 3.3 2 1 0 2 2 2 0 USP8 dimerisation domain ZZ PF00569.17 EMD65948.1 - 0.83 9.5 5.6 1.6 8.6 5.6 1.4 1 0 0 1 1 1 0 Zinc finger, ZZ type DUF3425 PF11905.8 EMD65950.1 - 1.2e-27 96.3 0.8 1.5e-27 96.1 0.8 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) ADC PF06314.11 EMD65951.1 - 1.3e-39 136.1 0.0 1.6e-39 135.9 0.0 1.0 1 0 0 1 1 1 1 Acetoacetate decarboxylase (ADC) adh_short PF00106.25 EMD65952.1 - 2.4e-23 82.6 0.0 7.6e-17 61.4 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EMD65952.1 - 9e-13 48.3 0.1 2.2e-09 37.2 0.1 2.3 2 1 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD65952.1 - 9.6e-05 22.4 0.2 0.00014 21.8 0.2 1.2 1 0 0 1 1 1 1 KR domain Enoyl_reductase PF12241.8 EMD65952.1 - 0.066 12.6 0.4 0.75 9.1 0.1 2.1 2 0 0 2 2 2 0 Trans-2-enoyl-CoA reductase catalytic region Peptidase_C39_2 PF13529.6 EMD65953.1 - 0.01 16.4 0.0 0.016 15.7 0.0 1.3 1 0 0 1 1 1 1 Peptidase_C39 like family Peptidase_C1 PF00112.23 EMD65953.1 - 0.016 15.3 3.9 1.1 9.3 0.6 2.8 2 1 0 2 2 2 0 Papain family cysteine protease ATPase PF06745.13 EMD65956.1 - 0.095 12.0 0.2 0.3 10.4 0.2 1.8 1 1 0 1 1 1 0 KaiC Apolipoprotein PF01442.18 EMD65957.1 - 0.062 13.2 4.5 0.14 12.0 4.5 1.5 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain HSCB_C PF07743.13 EMD65957.1 - 0.76 10.3 4.1 2.1 8.9 1.8 2.2 2 0 0 2 2 2 0 HSCB C-terminal oligomerisation domain DUF389 PF04087.14 EMD65958.1 - 0.063 13.3 0.6 0.25 11.4 0.0 2.0 1 1 1 3 3 3 0 Domain of unknown function (DUF389) MARVEL PF01284.23 EMD65958.1 - 0.1 12.7 13.5 0.21 11.6 13.2 1.7 1 1 0 1 1 1 0 Membrane-associating domain SBF_like PF13593.6 EMD65959.1 - 2.5e-95 319.4 28.6 2.9e-95 319.2 28.6 1.0 1 0 0 1 1 1 1 SBF-like CPA transporter family (DUF4137) Peptidase_M16_M PF16187.5 EMD65959.1 - 0.04 13.2 0.1 0.068 12.5 0.1 1.3 1 0 0 1 1 1 0 Middle or third domain of peptidase_M16 5-FTHF_cyc-lig PF01812.20 EMD65960.1 - 3.8e-05 23.6 0.0 8.4e-05 22.5 0.0 1.5 1 1 1 2 2 2 1 5-formyltetrahydrofolate cyclo-ligase family FMN_red PF03358.15 EMD65961.1 - 1e-23 83.8 0.0 2.1e-23 82.8 0.0 1.5 2 0 0 2 2 2 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 EMD65961.1 - 0.062 13.0 0.0 0.1 12.3 0.0 1.5 1 0 0 1 1 1 0 Flavodoxin-like fold 7tm_1 PF00001.21 EMD65963.1 - 0.068 12.5 6.8 0.15 11.4 6.8 1.5 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) ATG19_autophagy PF12744.7 EMD65963.1 - 0.14 11.3 1.3 0.2 10.8 1.3 1.1 1 0 0 1 1 1 0 Autophagy protein Atg19, Atg8-binding His_Phos_1 PF00300.22 EMD65964.1 - 4.3e-10 39.6 0.0 1.1e-09 38.2 0.0 1.7 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) HET PF06985.11 EMD65965.1 - 3.4e-31 108.6 0.1 3.4e-31 108.6 0.1 2.0 2 0 0 2 2 2 1 Heterokaryon incompatibility protein (HET) ANAPC4_WD40 PF12894.7 EMD65965.1 - 9e-07 29.1 0.0 0.00085 19.6 0.0 3.0 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain YL1 PF05764.13 EMD65965.1 - 0.0097 16.0 10.5 0.017 15.3 10.5 1.3 1 0 0 1 1 1 1 YL1 nuclear protein BUD22 PF09073.10 EMD65965.1 - 0.03 13.7 8.4 0.05 12.9 8.4 1.2 1 0 0 1 1 1 0 BUD22 SDA1 PF05285.12 EMD65965.1 - 0.14 11.5 11.8 0.26 10.7 11.8 1.3 1 0 0 1 1 1 0 SDA1 CDC45 PF02724.14 EMD65965.1 - 0.37 9.0 8.5 0.55 8.5 8.5 1.1 1 0 0 1 1 1 0 CDC45-like protein RNA_polI_A34 PF08208.11 EMD65965.1 - 0.39 10.8 7.9 0.73 9.9 7.9 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 Nop14 PF04147.12 EMD65965.1 - 0.67 8.1 11.4 0.95 7.6 11.4 1.1 1 0 0 1 1 1 0 Nop14-like family RRN3 PF05327.11 EMD65965.1 - 1.1 7.7 7.9 1.8 7.0 7.9 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 TFIIF_alpha PF05793.12 EMD65965.1 - 1.8 7.1 20.5 2.9 6.4 20.5 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Sigma70_ner PF04546.13 EMD65965.1 - 3.7 7.4 8.8 8.6 6.2 8.8 1.5 1 0 0 1 1 1 0 Sigma-70, non-essential region Glyco_hydro_61 PF03443.14 EMD65966.1 - 6.4e-58 196.1 0.1 7.7e-58 195.8 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 Ank_4 PF13637.6 EMD65967.1 - 1.3e-23 83.1 0.1 1.1e-06 29.0 0.0 6.2 4 2 4 8 8 8 5 Ankyrin repeats (many copies) Ank_2 PF12796.7 EMD65967.1 - 3.8e-21 75.5 0.0 2.8e-08 34.2 0.0 4.1 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EMD65967.1 - 7.6e-16 58.0 0.0 4.3e-05 23.7 0.0 4.3 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 EMD65967.1 - 2.4e-14 53.0 0.0 0.11 13.0 0.0 6.5 6 0 0 6 6 6 4 Ankyrin repeat Ank_3 PF13606.6 EMD65967.1 - 7.2e-13 47.5 0.0 0.62 10.8 0.0 6.9 7 1 0 7 7 7 3 Ankyrin repeat NACHT PF05729.12 EMD65967.1 - 2.3e-12 47.2 0.0 1e-11 45.1 0.0 2.1 2 0 0 2 2 2 1 NACHT domain AAA_16 PF13191.6 EMD65967.1 - 1e-05 26.0 0.0 2.9e-05 24.5 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EMD65967.1 - 0.024 14.9 0.0 0.097 12.9 0.0 2.1 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EMD65967.1 - 0.03 14.7 0.0 0.086 13.2 0.0 1.8 1 0 0 1 1 1 0 RNA helicase AAA_19 PF13245.6 EMD65967.1 - 0.062 13.6 0.0 0.19 12.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain Pkinase PF00069.25 EMD65968.1 - 3.6e-11 42.9 0.0 8.3e-11 41.7 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD65968.1 - 3.8e-05 23.1 0.0 0.0001 21.7 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Peptidase_M28 PF04389.17 EMD65970.1 - 3.9e-36 124.6 0.0 7.6e-36 123.7 0.0 1.5 1 1 0 1 1 1 1 Peptidase family M28 Sugar_tr PF00083.24 EMD65972.1 - 2.9e-83 280.3 11.1 3.2e-83 280.1 11.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD65972.1 - 7e-10 38.4 32.1 2.7e-05 23.3 22.9 2.1 1 1 0 2 2 2 2 Major Facilitator Superfamily HET PF06985.11 EMD65973.1 - 1e-20 74.6 3.1 1.3e-20 74.2 3.1 1.1 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) USP7_C2 PF14533.6 EMD65973.1 - 0.086 12.5 0.1 0.099 12.3 0.1 1.2 1 0 0 1 1 1 0 Ubiquitin-specific protease C-terminal DUF5326 PF17260.2 EMD65974.1 - 0.0011 19.1 0.6 0.0018 18.4 0.6 1.4 1 0 0 1 1 1 1 Family of unknown function (DUF5326) PAZ PF02170.22 EMD65974.1 - 0.02 14.7 0.0 0.048 13.5 0.0 1.6 1 0 0 1 1 1 0 PAZ domain Methyltransf_2 PF00891.18 EMD65975.1 - 4.6e-22 78.3 0.0 1.3e-21 76.9 0.0 1.7 2 0 0 2 2 2 1 O-methyltransferase domain Methyltransf_25 PF13649.6 EMD65975.1 - 0.0016 19.1 0.0 0.0067 17.1 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMD65975.1 - 0.13 13.1 0.0 0.63 10.8 0.0 2.3 1 0 0 1 1 1 0 Methyltransferase domain XAF1_C PF18608.1 EMD65975.1 - 0.2 11.2 5.4 0.05 13.2 1.9 1.8 2 0 0 2 2 2 0 XIAP-associated factor 1 C-terminal domain NGP1NT PF08153.12 EMD65976.1 - 2.9e-45 153.6 0.1 5.6e-45 152.7 0.1 1.5 1 0 0 1 1 1 1 NGP1NT (NUC091) domain MMR_HSR1 PF01926.23 EMD65976.1 - 1.2e-16 60.8 0.0 8.1e-13 48.5 0.0 3.3 2 1 0 2 2 2 2 50S ribosome-binding GTPase FeoB_N PF02421.18 EMD65976.1 - 2.6e-05 23.8 0.0 0.00035 20.1 0.0 2.2 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EMD65976.1 - 0.00083 19.3 0.0 0.0022 17.9 0.0 1.7 1 1 0 1 1 1 1 RsgA GTPase Arf PF00025.21 EMD65976.1 - 0.0045 16.5 0.0 0.1 12.1 0.0 2.2 2 0 0 2 2 2 1 ADP-ribosylation factor family Dynamin_N PF00350.23 EMD65976.1 - 0.0069 16.5 3.9 1.3 9.0 0.0 3.9 4 1 1 5 5 5 1 Dynamin family Sigma70_ner PF04546.13 EMD65976.1 - 0.15 11.9 8.7 0.31 10.9 8.7 1.6 1 0 0 1 1 1 0 Sigma-70, non-essential region WD40 PF00400.32 EMD65978.1 - 1.4e-33 114.3 11.7 9.1e-11 42.1 0.2 5.1 5 0 0 5 5 4 4 WD domain, G-beta repeat NACHT PF05729.12 EMD65978.1 - 2.9e-14 53.3 1.6 5.2e-12 46.0 1.6 2.3 1 1 0 1 1 1 1 NACHT domain ANAPC4_WD40 PF12894.7 EMD65978.1 - 3.5e-10 40.0 2.1 0.012 15.8 0.1 3.9 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EMD65978.1 - 2.5e-06 26.5 1.8 0.13 10.8 0.1 3.2 1 1 2 3 3 3 3 Nucleoporin Nup120/160 PQQ_2 PF13360.6 EMD65978.1 - 0.00011 21.8 2.2 0.00028 20.6 2.2 1.6 1 0 0 1 1 1 1 PQQ-like domain Ge1_WD40 PF16529.5 EMD65978.1 - 0.00014 20.9 5.7 1.5 7.7 0.2 3.2 1 1 2 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein PALB2_WD40 PF16756.5 EMD65978.1 - 0.0003 19.9 0.1 1.3 7.9 0.0 3.1 1 1 2 3 3 3 2 Partner and localizer of BRCA2 WD40 domain PDDEXK_1 PF12705.7 EMD65978.1 - 0.00055 19.9 0.0 4.5 7.1 0.0 3.9 2 1 1 3 3 3 2 PD-(D/E)XK nuclease superfamily Cytochrom_D1 PF02239.16 EMD65978.1 - 0.0056 15.3 0.7 0.097 11.2 0.1 2.5 2 1 0 3 3 3 1 Cytochrome D1 heme domain RNA_helicase PF00910.22 EMD65978.1 - 0.042 14.2 0.3 0.32 11.4 0.1 2.4 3 0 0 3 3 3 0 RNA helicase PQQ_3 PF13570.6 EMD65978.1 - 0.054 14.0 1.9 15 6.2 0.1 3.7 4 0 0 4 4 4 0 PQQ-like domain HTH_Tnp_Tc5 PF03221.16 EMD65979.1 - 4.6e-09 36.2 0.1 9.4e-09 35.2 0.1 1.6 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EMD65979.1 - 0.0018 18.0 0.1 0.0028 17.3 0.1 1.3 1 0 0 1 1 1 1 helix-turn-helix, Psq domain Ribosomal_S13_N PF08069.12 EMD65979.1 - 0.021 14.9 0.1 0.065 13.3 0.0 1.8 2 0 0 2 2 2 0 Ribosomal S13/S15 N-terminal domain Drf_GBD PF06371.13 EMD65979.1 - 0.022 14.3 0.0 0.027 14.0 0.0 1.2 1 0 0 1 1 1 0 Diaphanous GTPase-binding Domain TnsD PF15978.5 EMD65979.1 - 0.038 13.0 0.3 0.044 12.8 0.3 1.2 1 0 0 1 1 1 0 Tn7-like transposition protein D Cdc6_C PF09079.11 EMD65979.1 - 0.073 13.1 0.2 9.3 6.3 0.0 2.6 3 0 0 3 3 3 0 CDC6, C terminal winged helix domain HTH_24 PF13412.6 EMD65979.1 - 0.11 12.1 0.1 0.79 9.3 0.0 2.2 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding MFS_1 PF07690.16 EMD65980.1 - 6.5e-16 58.2 59.3 6.7e-15 54.9 26.1 2.5 2 1 1 3 3 3 2 Major Facilitator Superfamily TRI12 PF06609.13 EMD65980.1 - 6.8e-12 44.6 13.0 6.8e-12 44.6 13.0 1.6 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Transferase PF02458.15 EMD65981.1 - 0.00039 19.2 0.0 0.00058 18.6 0.0 1.4 1 1 0 1 1 1 1 Transferase family NOA36 PF06524.12 EMD65982.1 - 0.65 9.3 21.0 1 8.7 21.0 1.2 1 0 0 1 1 1 0 NOA36 protein ORC_WH_C PF18137.1 EMD65982.1 - 0.81 9.8 8.2 1.7 8.7 8.2 1.5 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal Vfa1 PF08432.10 EMD65982.1 - 2.4 8.5 18.0 3.4 7.9 18.0 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 SDA1 PF05285.12 EMD65982.1 - 2.7 7.3 25.8 3.7 6.9 25.8 1.1 1 0 0 1 1 1 0 SDA1 CobT PF06213.12 EMD65982.1 - 3.9 6.8 18.5 6.4 6.1 18.5 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DNA_pol_phi PF04931.13 EMD65982.1 - 5.5 5.0 29.1 7.9 4.4 29.1 1.1 1 0 0 1 1 1 0 DNA polymerase phi DUF2457 PF10446.9 EMD65982.1 - 7.3 5.6 30.8 11 5.1 30.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) SAPS PF04499.15 EMD65982.1 - 8.4 5.0 12.9 13 4.4 12.9 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Zip PF02535.22 EMD65982.1 - 8.7 5.4 7.5 6.5 5.9 5.5 1.7 2 0 0 2 2 2 0 ZIP Zinc transporter NPR3 PF03666.13 EMD65982.1 - 9.6 4.9 11.1 13 4.4 11.1 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 MFS_1 PF07690.16 EMD65987.1 - 6e-18 64.9 32.8 6e-18 64.9 32.8 2.8 2 1 1 3 3 3 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EMD65987.1 - 0.26 10.1 35.2 31 3.3 35.2 2.6 1 1 0 1 1 1 0 Sugar (and other) transporter Phage_holin_7_1 PF16081.5 EMD65987.1 - 1.5 9.0 8.5 8.1 6.6 2.9 2.6 2 0 0 2 2 2 0 Mycobacterial 2 TMS Phage Holin (M2 Hol) Family SET PF00856.28 EMD65988.1 - 1.8e-15 57.7 0.0 4.5e-15 56.4 0.0 1.7 2 0 0 2 2 2 1 SET domain Rubis-subs-bind PF09273.11 EMD65988.1 - 3.4e-10 40.7 2.4 9.1e-10 39.3 2.4 1.9 1 1 0 1 1 1 1 Rubisco LSMT substrate-binding ApoC-I PF04691.12 EMD65988.1 - 0.15 12.0 0.7 3.3 7.7 0.1 2.7 2 0 0 2 2 2 0 Apolipoprotein C-I (ApoC-1) CENP-B_dimeris PF09026.10 EMD65988.1 - 0.41 11.1 12.1 0.35 11.3 4.3 2.4 2 0 0 2 2 2 0 Centromere protein B dimerisation domain zf-RING_2 PF13639.6 EMD65989.1 - 0.0024 18.2 0.2 0.004 17.4 0.2 1.3 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 EMD65989.1 - 0.024 14.7 0.3 0.042 13.9 0.3 1.4 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_5 PF14634.6 EMD65989.1 - 0.034 14.1 0.3 0.058 13.4 0.3 1.3 1 0 0 1 1 1 0 zinc-RING finger domain Zn_ribbon_17 PF17120.5 EMD65989.1 - 0.36 10.5 2.1 2.7 7.7 2.1 2.0 1 1 0 1 1 1 0 Zinc-ribbon, C4HC2 type Dynamin_N PF00350.23 EMD65991.1 - 2e-14 54.0 0.0 9.3e-14 51.8 0.0 2.2 2 1 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.23 EMD65991.1 - 1.9e-06 27.9 0.1 5.9e-05 23.1 0.1 2.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EMD65991.1 - 1.7e-05 24.8 3.8 0.0029 17.5 0.1 2.9 2 1 1 3 3 3 2 RsgA GTPase AAA_16 PF13191.6 EMD65991.1 - 0.0084 16.5 0.1 0.034 14.5 0.1 2.1 1 1 0 1 1 1 1 AAA ATPase domain Roc PF08477.13 EMD65991.1 - 0.013 15.7 0.0 0.041 14.1 0.0 1.9 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase ABC_tran PF00005.27 EMD65991.1 - 0.09 13.3 1.1 0.3 11.6 0.0 2.5 3 0 0 3 3 3 0 ABC transporter DUF5320 PF17253.2 EMD65991.1 - 0.093 13.8 3.7 0.96 10.5 0.0 3.3 3 0 0 3 3 3 0 Family of unknown function (DUF5320) FapA PF03961.13 EMD65991.1 - 0.13 10.8 10.8 0.042 12.5 2.1 2.7 3 0 0 3 3 3 0 Flagellar Assembly Protein A Iso_dh PF00180.20 EMD65992.1 - 3.9e-95 318.9 0.0 5.3e-95 318.5 0.0 1.2 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase DUF1769 PF08588.10 EMD65993.1 - 1.7e-24 85.8 0.3 3.2e-24 84.9 0.3 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1769) DUF3506 PF12014.8 EMD65994.1 - 1.3e-53 180.7 0.0 2.5e-53 179.8 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3506) F-box-like PF12937.7 EMD65994.1 - 1.5e-08 34.4 0.5 3.6e-08 33.2 0.5 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EMD65994.1 - 5.9e-07 29.2 1.5 1.2e-06 28.3 0.2 2.2 2 0 0 2 2 2 1 F-box domain Herpes_UL14 PF03580.14 EMD65995.1 - 0.42 10.9 6.6 11 6.2 0.1 3.3 3 0 0 3 3 3 0 Herpesvirus UL14-like protein MUG113 PF13455.6 EMD65995.1 - 0.77 10.5 2.7 1.8 9.3 0.1 2.7 3 0 0 3 3 3 0 Meiotically up-regulated gene 113 zf-C2H2 PF00096.26 EMD65996.1 - 0.042 14.3 0.1 3.9 8.1 0.1 2.5 2 0 0 2 2 2 0 Zinc finger, C2H2 type RNase_H PF00075.24 EMD65999.1 - 6.8e-16 58.7 0.1 8.9e-16 58.4 0.1 1.2 1 0 0 1 1 1 1 RNase H RVT_3 PF13456.6 EMD65999.1 - 3.3e-05 23.7 0.0 5.1e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase-like SoDot-IcmSS PF16848.5 EMD65999.1 - 0.094 12.7 0.1 0.13 12.3 0.1 1.2 1 0 0 1 1 1 0 Substrate of the Dot/Icm secretion system, putative Asp PF00026.23 EMD66001.1 - 1.6e-12 47.5 0.0 2.3e-12 47.0 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease Podoplanin PF05808.11 EMD66001.1 - 0.0088 16.2 0.1 0.015 15.4 0.1 1.3 1 0 0 1 1 1 1 Podoplanin PTP_tm PF18861.1 EMD66001.1 - 0.19 11.7 0.3 0.35 10.8 0.3 1.3 1 0 0 1 1 1 0 Transmembrane domain of protein tyrosine phosphatase, receptor type J VSP PF03302.13 EMD66001.1 - 0.28 10.0 0.2 0.41 9.5 0.2 1.1 1 0 0 1 1 1 0 Giardia variant-specific surface protein SKG6 PF08693.10 EMD66001.1 - 2.3 7.7 6.4 3.7 7.0 6.4 1.3 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Methyltransf_2 PF00891.18 EMD66002.1 - 1.4e-13 50.6 0.2 3e-13 49.6 0.2 1.6 1 1 0 1 1 1 1 O-methyltransferase domain Dimerisation PF08100.11 EMD66002.1 - 0.074 13.1 0.0 0.14 12.2 0.0 1.5 1 0 0 1 1 1 0 Dimerisation domain Methyltransf_23 PF13489.6 EMD66003.1 - 2.8e-18 66.3 0.0 5e-18 65.5 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMD66003.1 - 1.9e-12 47.7 0.0 4.3e-12 46.6 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMD66003.1 - 9.6e-11 41.7 0.0 2.4e-09 37.2 0.0 2.6 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMD66003.1 - 6.2e-09 36.5 0.0 3.1e-08 34.3 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMD66003.1 - 9.8e-09 35.8 0.0 2.6e-08 34.4 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EMD66003.1 - 0.00021 20.9 0.0 0.0022 17.6 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_4 PF02390.17 EMD66003.1 - 0.00079 18.9 0.0 0.002 17.6 0.0 1.6 2 0 0 2 2 2 1 Putative methyltransferase PrmA PF06325.13 EMD66003.1 - 0.016 14.7 0.0 0.035 13.5 0.0 1.5 2 0 0 2 2 2 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_16 PF10294.9 EMD66003.1 - 0.023 14.4 0.0 0.038 13.7 0.0 1.2 1 0 0 1 1 1 0 Lysine methyltransferase Methyltransf_2 PF00891.18 EMD66003.1 - 0.035 13.4 0.0 0.17 11.1 0.0 2.0 2 0 0 2 2 2 0 O-methyltransferase domain FtsJ PF01728.19 EMD66003.1 - 0.18 11.9 0.0 0.94 9.6 0.0 1.9 2 0 0 2 2 2 0 FtsJ-like methyltransferase Sod_Fe_C PF02777.18 EMD66004.1 - 1.6e-36 124.6 0.4 2.6e-36 123.9 0.4 1.3 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 EMD66004.1 - 5.3e-35 119.7 4.0 1.4e-34 118.4 1.3 2.1 2 0 0 2 2 2 1 Iron/manganese superoxide dismutases, alpha-hairpin domain IMUP PF15761.5 EMD66005.1 - 0.025 15.3 3.2 0.025 15.3 3.2 2.1 2 0 0 2 2 2 0 Immortalisation up-regulated protein DUF3446 PF11928.8 EMD66005.1 - 0.39 11.0 9.6 0.52 10.7 2.0 2.3 2 0 0 2 2 2 0 Early growth response N-terminal domain Na_H_Exchanger PF00999.21 EMD66006.1 - 2.1e-27 95.9 37.6 2.1e-23 82.8 24.7 2.6 2 1 0 2 2 2 2 Sodium/hydrogen exchanger family Pex14_N PF04695.13 EMD66006.1 - 0.14 12.8 1.5 2.4 8.8 0.1 2.5 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Glyco_hydro_cc PF11790.8 EMD66007.1 - 8.3e-30 104.1 2.1 7.2e-19 68.3 2.3 2.1 1 1 1 2 2 2 2 Glycosyl hydrolase catalytic core Asparaginase PF00710.20 EMD66008.1 - 2.2e-33 115.4 0.0 3.1e-33 114.9 0.0 1.2 1 0 0 1 1 1 1 Asparaginase, N-terminal Asparaginase_C PF17763.1 EMD66008.1 - 6.2e-14 52.2 0.0 1.3e-13 51.2 0.0 1.6 1 0 0 1 1 1 1 Glutaminase/Asparaginase C-terminal domain PA PF02225.22 EMD66008.1 - 0.11 12.6 0.1 0.21 11.6 0.1 1.5 1 0 0 1 1 1 0 PA domain DUF3482 PF11981.8 EMD66008.1 - 0.25 10.7 0.1 0.38 10.1 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3482) HET PF06985.11 EMD66009.1 - 1.2e-22 80.9 0.0 2.3e-22 79.9 0.0 1.5 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) AMP-binding PF00501.28 EMD66011.1 - 4.6e-133 443.9 0.0 8.1e-73 245.4 0.0 2.2 2 0 0 2 2 2 2 AMP-binding enzyme Condensation PF00668.20 EMD66011.1 - 7.4e-123 410.6 0.0 1.8e-43 148.9 0.0 3.6 3 1 0 3 3 3 3 Condensation domain PP-binding PF00550.25 EMD66011.1 - 1.9e-23 82.6 0.7 5.5e-12 45.9 0.0 3.3 3 0 0 3 3 3 2 Phosphopantetheine attachment site AMP-binding_C PF13193.6 EMD66011.1 - 6.6e-05 23.8 0.0 0.028 15.4 0.0 2.7 2 0 0 2 2 2 2 AMP-binding enzyme C-terminal domain PDZ_6 PF17820.1 EMD66011.1 - 0.19 11.6 0.1 2 8.3 0.0 2.5 2 0 0 2 2 2 0 PDZ domain RNase_H PF00075.24 EMD66012.1 - 1.2e-07 32.0 0.0 2.8e-07 30.8 0.0 1.6 1 1 0 1 1 1 1 RNase H DDE_1 PF03184.19 EMD66013.1 - 1.3e-14 54.2 0.0 1.9e-14 53.7 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.6 EMD66013.1 - 6.9e-05 22.6 0.0 0.0061 16.3 0.0 2.2 1 1 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EMD66013.1 - 0.022 14.8 0.0 0.06 13.4 0.0 1.7 1 0 0 1 1 1 0 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EMD66014.1 - 6.7e-05 22.6 0.6 9.5e-05 22.1 0.6 1.4 1 0 0 1 1 1 1 helix-turn-helix, Psq domain CENP-B_N PF04218.13 EMD66014.1 - 0.0056 16.3 0.4 0.53 10.0 0.0 2.1 2 0 0 2 2 2 2 CENP-B N-terminal DNA-binding domain DUF3413 PF11893.8 EMD66014.1 - 0.022 14.0 0.2 0.024 13.8 0.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3413) BrkDBD PF09607.10 EMD66014.1 - 0.11 12.3 0.2 0.16 11.7 0.1 1.5 1 1 0 1 1 1 0 Brinker DNA-binding domain ZnuA PF01297.17 EMD66014.1 - 0.15 11.4 0.6 0.16 11.4 0.6 1.0 1 0 0 1 1 1 0 Zinc-uptake complex component A periplasmic ABC_membrane PF00664.23 EMD66015.1 - 1.2e-84 284.3 37.4 2.7e-43 148.6 15.2 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EMD66015.1 - 6.2e-65 217.8 0.0 2.7e-34 118.6 0.0 3.2 2 1 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EMD66015.1 - 8.7e-15 54.7 5.3 4.2e-08 32.9 0.2 4.3 3 2 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 EMD66015.1 - 5e-09 36.5 0.3 0.0066 16.7 0.1 3.6 3 1 0 3 3 3 2 AAA domain AAA_30 PF13604.6 EMD66015.1 - 3.7e-07 30.0 0.2 0.022 14.5 0.0 3.2 3 1 0 3 3 2 2 AAA domain AAA_29 PF13555.6 EMD66015.1 - 5.3e-07 29.3 0.5 0.0022 17.7 0.2 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 EMD66015.1 - 7.6e-07 29.7 0.3 0.072 13.5 0.1 3.3 3 1 0 3 3 3 2 AAA ATPase domain RsgA_GTPase PF03193.16 EMD66015.1 - 4.1e-06 26.8 0.0 0.12 12.3 0.0 2.7 2 0 0 2 2 2 2 RsgA GTPase AAA_21 PF13304.6 EMD66015.1 - 4.2e-06 26.8 1.4 0.69 9.7 0.1 3.6 3 1 1 4 4 3 2 AAA domain, putative AbiEii toxin, Type IV TA system ABC_ATPase PF09818.9 EMD66015.1 - 1.6e-05 23.9 0.0 0.19 10.5 0.0 3.3 3 0 0 3 3 3 2 Predicted ATPase of the ABC class AAA_25 PF13481.6 EMD66015.1 - 0.00013 21.6 0.0 0.57 9.7 0.0 2.9 3 0 0 3 3 3 2 AAA domain AAA_15 PF13175.6 EMD66015.1 - 0.00017 21.5 0.0 0.13 11.9 0.0 2.2 2 0 0 2 2 2 2 AAA ATPase domain AAA_23 PF13476.6 EMD66015.1 - 0.0002 21.9 0.0 0.015 15.8 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 EMD66015.1 - 0.00022 21.6 2.4 15 6.0 0.3 4.4 3 1 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 EMD66015.1 - 0.00087 19.3 0.0 0.43 10.5 0.0 2.6 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_28 PF13521.6 EMD66015.1 - 0.0043 17.3 0.1 1.4 9.2 0.0 2.7 2 0 0 2 2 2 1 AAA domain SRP54 PF00448.22 EMD66015.1 - 0.0044 16.7 0.0 2 8.0 0.0 2.6 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_7 PF12775.7 EMD66015.1 - 0.0059 16.1 0.0 0.96 8.9 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region Zeta_toxin PF06414.12 EMD66015.1 - 0.0066 15.8 0.0 0.74 9.1 0.0 2.6 2 0 0 2 2 2 1 Zeta toxin DUF87 PF01935.17 EMD66015.1 - 0.0067 16.5 1.1 4.5 7.3 0.1 3.0 3 0 0 3 3 3 1 Helicase HerA, central domain AAA_18 PF13238.6 EMD66015.1 - 0.01 16.4 0.0 8.1 7.0 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 EMD66015.1 - 0.011 15.9 0.0 2 8.6 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 EMD66015.1 - 0.011 15.7 0.0 5.9 6.9 0.0 2.8 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 EMD66015.1 - 0.011 15.7 0.0 12 5.9 0.0 3.9 4 0 0 4 4 4 0 AAA domain ATP_bind_1 PF03029.17 EMD66015.1 - 0.018 14.8 0.1 0.34 10.6 0.0 2.4 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein RNA_helicase PF00910.22 EMD66015.1 - 0.024 15.0 0.0 19 5.7 0.0 3.3 3 0 0 3 3 3 0 RNA helicase SbcCD_C PF13558.6 EMD66015.1 - 0.025 14.8 0.9 1.1 9.6 0.2 3.3 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA_10 PF12846.7 EMD66015.1 - 0.034 13.1 0.0 3.2 6.6 0.0 2.5 2 1 0 2 2 2 0 AAA-like domain AAA_24 PF13479.6 EMD66015.1 - 0.037 13.8 0.0 3.7 7.2 0.0 2.5 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 EMD66015.1 - 0.049 13.7 0.0 16 5.7 0.0 3.0 2 0 0 2 2 2 0 50S ribosome-binding GTPase G-alpha PF00503.20 EMD66015.1 - 0.05 12.7 0.0 3.2 6.8 0.0 2.3 2 0 0 2 2 2 0 G-protein alpha subunit AAA_17 PF13207.6 EMD66015.1 - 0.069 13.6 0.1 18 5.8 0.0 3.4 3 0 0 3 3 3 0 AAA domain PRK PF00485.18 EMD66015.1 - 0.086 12.6 0.0 17 5.1 0.0 2.4 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family NB-ARC PF00931.22 EMD66015.1 - 0.15 11.3 0.1 6.3 5.9 0.1 2.5 3 0 0 3 3 3 0 NB-ARC domain 3HCDH_N PF02737.18 EMD66016.1 - 7.5e-31 107.4 0.0 2.4e-29 102.5 0.0 2.3 1 1 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 EMD66016.1 - 1.8e-13 50.9 0.0 3.4e-13 50.0 0.0 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain NAD_binding_8 PF13450.6 EMD66016.1 - 0.049 13.9 0.0 0.12 12.6 0.0 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain AMP-binding PF00501.28 EMD66017.1 - 1.2e-64 218.5 0.0 1.6e-64 218.1 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme PP-binding PF00550.25 EMD66017.1 - 2.4e-07 31.0 0.0 4.5e-07 30.1 0.0 1.5 1 0 0 1 1 1 1 Phosphopantetheine attachment site AMP-binding_C PF13193.6 EMD66017.1 - 6.1e-05 23.9 0.0 0.00014 22.8 0.0 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain SpoIIIAC PF06686.11 EMD66017.1 - 0.028 14.6 0.0 0.072 13.3 0.0 1.7 1 0 0 1 1 1 0 Stage III sporulation protein AC/AD protein family adh_short PF00106.25 EMD66018.1 - 1.4e-40 138.8 1.0 4.4e-40 137.2 1.0 1.6 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD66018.1 - 2e-28 99.6 0.3 2.9e-28 99.0 0.3 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD66018.1 - 3.9e-08 33.4 0.4 8.8e-08 32.3 0.3 1.5 1 1 1 2 2 2 1 KR domain NAD_binding_10 PF13460.6 EMD66018.1 - 7.8e-08 32.4 0.0 1.2e-07 31.8 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EMD66018.1 - 3.2e-07 30.1 0.0 4.4e-07 29.6 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EMD66018.1 - 0.0013 18.0 0.1 0.0018 17.5 0.1 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Sacchrp_dh_NADP PF03435.18 EMD66018.1 - 0.012 15.9 0.0 0.021 15.1 0.0 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain RmlD_sub_bind PF04321.17 EMD66018.1 - 0.014 14.5 0.1 0.02 14.0 0.1 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain DUF1776 PF08643.10 EMD66018.1 - 0.049 13.0 0.0 0.23 10.8 0.0 1.8 1 1 0 1 1 1 0 Fungal family of unknown function (DUF1776) Glyco_transf_4 PF13439.6 EMD66018.1 - 0.13 12.3 0.0 0.21 11.6 0.0 1.3 1 0 0 1 1 1 0 Glycosyltransferase Family 4 Gamma_PGA_hydro PF05908.11 EMD66018.1 - 0.13 11.6 0.0 0.2 11.0 0.0 1.2 1 0 0 1 1 1 0 Poly-gamma-glutamate hydrolase zf-RVT PF13966.6 EMD66019.1 - 0.00086 20.0 0.1 0.00093 19.9 0.1 1.1 1 0 0 1 1 1 1 zinc-binding in reverse transcriptase RVT_1 PF00078.27 EMD66020.1 - 0.00035 20.2 0.0 0.00039 20.0 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) MRFAP1 PF15155.6 EMD66021.1 - 0.016 15.7 1.7 0.038 14.5 1.7 1.6 1 0 0 1 1 1 0 MORF4 family-associated protein1 Med11 PF10280.9 EMD66021.1 - 0.079 13.4 3.8 0.15 12.5 3.1 1.7 1 1 0 1 1 1 0 Mediator complex protein eIF3g PF12353.8 EMD66021.1 - 4.7 7.6 14.1 1.8 9.0 0.6 3.3 2 1 1 3 3 3 0 Eukaryotic translation initiation factor 3 subunit G RVT_1 PF00078.27 EMD66023.1 - 0.00038 20.1 0.0 0.00043 19.9 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 EMD66024.1 - 5.3e-06 26.3 0.0 8e-06 25.7 0.0 1.3 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 EMD66024.1 - 0.055 13.0 0.0 0.055 13.0 0.0 1.2 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family FH2 PF02181.23 EMD66025.1 - 0.1 11.7 1.1 0.22 10.6 1.1 1.5 1 0 0 1 1 1 0 Formin Homology 2 Domain HAUS-augmin3 PF14932.6 EMD66025.1 - 0.17 11.4 4.6 0.36 10.4 4.6 1.5 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 eIF3g PF12353.8 EMD66025.1 - 3 8.2 14.5 1.7 9.1 1.1 3.3 2 1 1 3 3 3 0 Eukaryotic translation initiation factor 3 subunit G HTH_psq PF05225.16 EMD66026.1 - 1.1e-05 25.1 0.1 1.5e-05 24.6 0.1 1.4 1 1 0 1 1 1 1 helix-turn-helix, Psq domain HTH_10 PF04967.12 EMD66026.1 - 0.0057 16.4 0.1 0.0081 15.9 0.1 1.2 1 0 0 1 1 1 1 HTH DNA binding domain CENP-B_N PF04218.13 EMD66026.1 - 0.08 12.6 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain DDE_1 PF03184.19 EMD66028.1 - 5e-29 101.2 0.2 1.7e-28 99.4 0.0 2.0 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 EMD66028.1 - 4.6e-08 33.0 1.8 2.5e-06 27.4 0.0 3.2 2 1 0 2 2 2 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EMD66028.1 - 9e-06 25.3 0.1 9e-06 25.3 0.1 1.9 2 0 0 2 2 2 1 helix-turn-helix, Psq domain DDE_3 PF13358.6 EMD66028.1 - 0.01 15.6 0.0 0.2 11.4 0.0 2.7 1 1 0 1 1 1 0 DDE superfamily endonuclease Mt_ATP_synt PF15704.5 EMD66028.1 - 0.084 12.8 3.0 8.7 6.2 4.2 2.2 2 0 0 2 2 2 0 Mitochondrial ATP synthase subunit Cytochrom_C550 PF14495.6 EMD66028.1 - 0.11 12.2 2.1 0.19 11.5 1.3 1.8 2 0 0 2 2 2 0 Cytochrome c-550 domain UPF0175 PF03683.13 EMD66028.1 - 0.12 12.1 0.7 0.63 9.8 0.4 2.3 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0175) zf-C2H2_10 PF16588.5 EMD66028.1 - 0.33 10.7 6.1 0.65 9.8 6.1 1.5 1 0 0 1 1 1 0 C2H2 zinc-finger YabA PF06156.13 EMD66028.1 - 0.68 10.6 3.4 1.7 9.3 3.4 1.8 1 0 0 1 1 1 0 Initiation control protein YabA G-gamma PF00631.22 EMD66028.1 - 2.7 8.1 8.4 6.4 6.9 0.8 2.8 2 0 0 2 2 2 0 GGL domain Exo_endo_phos_2 PF14529.6 EMD66029.1 - 3.4e-07 30.1 0.0 4.4e-07 29.7 0.0 1.1 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Fungal_trans PF04082.18 EMD66030.1 - 0.00021 20.4 0.4 0.00046 19.3 0.4 1.7 1 1 0 1 1 1 1 Fungal specific transcription factor domain DUF3189 PF11385.8 EMD66031.1 - 0.099 12.5 0.0 0.12 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3189) F-box-like PF12937.7 EMD66032.1 - 9.2e-06 25.5 0.6 1.9e-05 24.5 0.6 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EMD66032.1 - 8.4e-05 22.3 1.5 8.4e-05 22.3 1.5 1.8 2 0 0 2 2 2 1 F-box domain Pkinase PF00069.25 EMD66034.1 - 3.1e-31 108.7 0.0 8.7e-31 107.2 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD66034.1 - 7.1e-18 64.8 0.0 5.8e-17 61.8 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMD66034.1 - 0.00093 18.6 0.0 0.0019 17.6 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EMD66034.1 - 0.0022 17.9 0.0 0.0048 16.9 0.0 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 EMD66034.1 - 0.0032 16.8 0.0 0.0058 16.0 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EMD66034.1 - 0.0046 15.8 0.0 0.011 14.6 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase Pec_lyase_N PF04431.13 EMD66035.1 - 0.0021 18.3 0.4 0.0047 17.1 0.2 1.8 1 1 0 1 1 1 1 Pectate lyase, N terminus BTB PF00651.31 EMD66036.1 - 2.1e-07 31.2 0.0 4.2e-07 30.2 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain Dynamin_N PF00350.23 EMD66037.1 - 1.7e-31 109.6 0.0 3.5e-31 108.5 0.0 1.6 1 0 0 1 1 1 1 Dynamin family Dynamin_M PF01031.20 EMD66037.1 - 2.1e-26 92.8 0.0 4.2e-26 91.8 0.0 1.4 1 0 0 1 1 1 1 Dynamin central region MMR_HSR1 PF01926.23 EMD66037.1 - 0.00015 21.8 0.0 0.0015 18.6 0.0 2.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase EH_Signature PF15611.6 EMD66037.1 - 0.0059 16.1 0.1 0.018 14.5 0.1 1.7 1 1 0 1 1 1 1 EH_Signature domain AAA_15 PF13175.6 EMD66037.1 - 0.028 14.1 0.0 0.11 12.2 0.0 1.8 1 1 0 1 1 1 0 AAA ATPase domain GED PF02212.18 EMD66037.1 - 0.029 14.5 0.3 0.93 9.7 0.1 3.2 3 0 0 3 3 3 0 Dynamin GTPase effector domain FeoB_N PF02421.18 EMD66037.1 - 0.12 11.9 0.0 10 5.6 0.0 2.5 2 0 0 2 2 2 0 Ferrous iron transport protein B AAA_29 PF13555.6 EMD66037.1 - 0.17 11.7 0.0 0.41 10.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain BTB PF00651.31 EMD66038.1 - 8.3e-12 45.3 0.0 1.2e-10 41.6 0.0 2.1 2 0 0 2 2 2 1 BTB/POZ domain BTB PF00651.31 EMD66041.1 - 7.7e-11 42.2 0.1 1.3e-10 41.5 0.1 1.4 1 0 0 1 1 1 1 BTB/POZ domain zf-RING_2 PF13639.6 EMD66042.1 - 6.7e-11 42.3 4.9 1.3e-10 41.4 4.9 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EMD66042.1 - 1.5e-07 31.1 5.2 1.5e-07 31.1 5.2 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EMD66042.1 - 8e-07 29.3 7.2 4.3e-06 26.9 7.2 2.1 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 EMD66042.1 - 2.5e-06 27.2 5.6 4.6e-06 26.4 5.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EMD66042.1 - 4.4e-05 23.4 1.8 8.4e-05 22.5 1.8 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_11 PF17123.5 EMD66042.1 - 5.1e-05 22.9 3.4 0.00019 21.1 3.4 2.0 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_3 PF13920.6 EMD66042.1 - 0.00011 22.0 3.3 0.00023 20.9 3.3 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EMD66042.1 - 0.0012 18.9 3.8 0.062 13.4 3.8 2.3 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3H2C3 PF17122.5 EMD66042.1 - 0.0073 16.3 3.1 0.019 15.0 3.1 1.7 1 0 0 1 1 1 1 Zinc-finger zf-RING_5 PF14634.6 EMD66042.1 - 0.018 15.0 4.2 0.038 13.9 4.2 1.6 1 0 0 1 1 1 0 zinc-RING finger domain Prok-RING_4 PF14447.6 EMD66042.1 - 0.018 14.9 4.9 0.041 13.8 4.9 1.7 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 TMEM247 PF15444.6 EMD66042.1 - 0.035 14.1 0.0 0.06 13.4 0.0 1.4 1 0 0 1 1 1 0 Transmembrane protein 247 Zn_ribbon_17 PF17120.5 EMD66042.1 - 0.09 12.4 3.7 0.18 11.5 3.7 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type PRTase_1 PF11202.8 EMD66042.1 - 0.14 11.4 0.1 0.2 10.9 0.1 1.2 1 0 0 1 1 1 0 Phosphoribosyl transferase (PRTase) FANCL_C PF11793.8 EMD66042.1 - 0.14 12.4 9.3 4.6 7.5 9.3 2.8 1 1 0 1 1 1 0 FANCL C-terminal domain zf-RING_4 PF14570.6 EMD66042.1 - 0.14 12.0 3.9 0.32 10.8 3.9 1.6 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain RINGv PF12906.7 EMD66042.1 - 0.51 10.5 4.0 1.4 9.1 4.0 1.7 1 1 0 1 1 1 0 RING-variant domain Methyltransf_23 PF13489.6 EMD66043.1 - 1.4e-20 73.8 0.0 2.1e-20 73.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMD66043.1 - 2.9e-18 66.3 0.0 4.4e-18 65.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMD66043.1 - 1e-17 64.3 0.0 1.4e-17 63.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EMD66043.1 - 1.5e-17 63.8 0.0 1.8e-17 63.6 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_25 PF13649.6 EMD66043.1 - 2.6e-16 60.1 0.0 4.1e-16 59.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMD66043.1 - 1.4e-14 54.6 0.0 2.1e-14 54.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EMD66043.1 - 2.4e-09 36.9 0.0 6.3e-08 32.2 0.0 2.0 1 1 1 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_9 PF08003.11 EMD66043.1 - 4.4e-07 29.1 0.0 5.7e-07 28.8 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) PCMT PF01135.19 EMD66043.1 - 1.3e-06 28.3 0.0 1.8e-06 27.8 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_15 PF09445.10 EMD66043.1 - 1.5e-06 27.9 0.0 1.9e-06 27.5 0.0 1.2 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase PrmA PF06325.13 EMD66043.1 - 4e-06 26.4 0.0 5.5e-06 26.0 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_18 PF12847.7 EMD66043.1 - 6.3e-06 26.2 0.0 1e-05 25.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EMD66043.1 - 6.7e-06 25.8 0.0 9.8e-06 25.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_32 PF13679.6 EMD66043.1 - 5.6e-05 23.2 0.0 8.1e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.16 EMD66043.1 - 8.6e-05 22.4 0.0 0.00011 22.1 0.0 1.1 1 0 0 1 1 1 1 Met-10+ like-protein UPF0020 PF01170.18 EMD66043.1 - 0.00035 20.3 0.0 0.0011 18.7 0.0 1.7 1 1 1 2 2 2 1 Putative RNA methylase family UPF0020 MetW PF07021.12 EMD66043.1 - 0.00043 19.9 0.0 0.00065 19.3 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW TehB PF03848.14 EMD66043.1 - 0.00072 19.0 0.0 0.001 18.5 0.0 1.1 1 0 0 1 1 1 1 Tellurite resistance protein TehB TPMT PF05724.11 EMD66043.1 - 0.0026 17.4 0.0 0.0039 16.9 0.0 1.3 1 1 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) Methyltransf_3 PF01596.17 EMD66043.1 - 0.0041 16.3 0.0 0.0056 15.9 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase N6_N4_Mtase PF01555.18 EMD66043.1 - 0.0052 16.5 0.0 0.13 12.0 0.0 2.1 2 0 0 2 2 2 1 DNA methylase Methyltransf_24 PF13578.6 EMD66043.1 - 0.015 16.3 0.1 0.027 15.5 0.1 1.4 1 0 0 1 1 1 0 Methyltransferase domain CheR PF01739.18 EMD66043.1 - 0.023 14.2 0.1 0.27 10.7 0.0 2.2 1 1 1 2 2 2 0 CheR methyltransferase, SAM binding domain Cons_hypoth95 PF03602.15 EMD66043.1 - 0.025 14.2 0.0 0.033 13.8 0.0 1.1 1 0 0 1 1 1 0 Conserved hypothetical protein 95 UPF0146 PF03686.13 EMD66043.1 - 0.027 14.3 0.0 0.043 13.7 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0146) PAS_3 PF08447.12 EMD66043.1 - 0.063 13.6 0.0 0.12 12.7 0.0 1.4 1 0 0 1 1 1 0 PAS fold 3HCDH_N PF02737.18 EMD66043.1 - 0.083 12.8 0.0 0.12 12.2 0.0 1.2 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Methyltransf_16 PF10294.9 EMD66043.1 - 0.12 12.1 0.0 0.16 11.7 0.0 1.2 1 0 0 1 1 1 0 Lysine methyltransferase Methyltr_RsmB-F PF01189.17 EMD66043.1 - 0.15 11.7 0.0 0.56 9.8 0.0 1.8 2 0 0 2 2 2 0 16S rRNA methyltransferase RsmB/F Herpes_UL69 PF05459.12 EMD66044.1 - 0.0029 17.0 0.1 0.0046 16.3 0.1 1.4 1 0 0 1 1 1 1 Herpesvirus transcriptional regulator family SET PF00856.28 EMD66047.1 - 3.3e-12 47.1 0.1 2.2e-11 44.4 0.1 2.2 1 1 0 1 1 1 1 SET domain TPR_2 PF07719.17 EMD66047.1 - 2.1e-06 27.4 2.4 0.27 11.5 0.1 3.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 EMD66047.1 - 0.00046 19.9 3.0 0.0061 16.3 0.1 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EMD66047.1 - 0.0017 18.4 0.5 0.04 14.0 0.1 2.8 2 0 0 2 2 2 1 Fis1 C-terminal tetratricopeptide repeat SRP_TPR_like PF17004.5 EMD66047.1 - 0.0019 18.2 0.1 0.0046 17.0 0.1 1.6 1 0 0 1 1 1 1 Putative TPR-like repeat TPR_14 PF13428.6 EMD66047.1 - 0.0049 17.6 0.1 0.029 15.2 0.1 2.4 2 0 0 2 2 1 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EMD66047.1 - 0.01 16.1 0.9 0.067 13.4 0.9 2.3 1 1 1 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 EMD66047.1 - 0.015 15.9 0.2 0.22 12.3 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.6 EMD66047.1 - 0.037 14.5 0.2 16 6.1 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.6 EMD66047.1 - 0.037 13.7 0.3 0.28 10.9 0.0 2.6 2 0 0 2 2 2 0 TPR repeat TPR_12 PF13424.6 EMD66047.1 - 0.33 11.3 1.6 4.9 7.5 0.3 3.0 2 1 0 2 2 2 0 Tetratricopeptide repeat DUF4364 PF14277.6 EMD66051.1 - 0.23 11.2 5.5 0.056 13.2 2.6 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4364) Ndc1_Nup PF09531.10 EMD66051.1 - 0.29 9.8 2.2 0.35 9.5 2.2 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Peptidase_S49_N PF08496.10 EMD66051.1 - 2.6 8.1 8.2 0.66 10.0 4.4 1.9 2 1 0 2 2 2 0 Peptidase family S49 N-terminal Glyco_hydro_61 PF03443.14 EMD66052.1 - 0.0011 19.0 0.0 0.0018 18.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 CBM_19 PF03427.13 EMD66052.1 - 0.042 13.8 7.2 0.15 12.0 7.2 2.0 1 0 0 1 1 1 0 Carbohydrate binding domain (family 19) DDE_1 PF03184.19 EMD66053.1 - 1.1e-15 57.8 0.0 2.4e-15 56.7 0.0 1.6 2 0 0 2 2 2 1 DDE superfamily endonuclease DDE_3 PF13358.6 EMD66053.1 - 0.059 13.1 0.0 0.17 11.6 0.0 1.7 1 0 0 1 1 1 0 DDE superfamily endonuclease Biotin_carb_N PF00289.22 EMD66053.1 - 0.06 13.9 0.2 2.6 8.6 0.0 2.3 2 0 0 2 2 2 0 Biotin carboxylase, N-terminal domain COesterase PF00135.28 EMD66054.1 - 2.4e-96 323.7 0.0 2.8e-96 323.4 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EMD66054.1 - 5.4e-06 26.4 0.0 0.00011 22.1 0.1 2.4 2 1 0 2 2 2 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EMD66054.1 - 0.076 12.5 0.0 0.14 11.6 0.0 1.4 1 0 0 1 1 1 0 Prolyl oligopeptidase family Synaptobrevin PF00957.21 EMD66055.1 - 6e-31 106.1 0.0 8.6e-31 105.6 0.0 1.2 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 EMD66055.1 - 7.7e-16 57.9 0.0 1.9e-15 56.7 0.0 1.6 2 0 0 2 2 2 1 Regulated-SNARE-like domain Viral_Beta_CD PF04530.12 EMD66055.1 - 0.18 12.1 0.3 15 5.9 0.1 2.4 2 0 0 2 2 2 0 Viral Beta C/D like family Ac110_PIF PF07280.11 EMD66055.1 - 5.8 6.8 7.5 9.9 6.0 7.5 1.4 1 0 0 1 1 1 0 Per os infectivity factor AC110 RNase_P_Rpp14 PF01900.19 EMD66056.1 - 4.9e-30 103.8 0.0 1.5e-29 102.2 0.0 1.8 1 1 0 1 1 1 1 Rpp14/Pop5 family MFS_1 PF07690.16 EMD66057.1 - 0.00015 20.8 6.9 0.00021 20.3 6.9 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Zn_clus PF00172.18 EMD66059.1 - 1.2e-07 31.7 14.9 5e-07 29.7 14.9 2.2 1 1 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain IHHNV_capsid PF16530.5 EMD66063.1 - 0.098 11.7 0.0 0.14 11.2 0.0 1.2 1 0 0 1 1 1 0 Infectious hypodermal and haematopoietic necrosis virus, capsid zf-C2H2_4 PF13894.6 EMD66064.1 - 0.00062 20.4 30.2 0.13 13.2 2.6 6.1 6 0 0 6 6 6 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EMD66064.1 - 0.01 16.1 17.3 0.23 11.8 0.1 5.1 3 2 1 4 4 4 0 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 EMD66064.1 - 0.014 15.3 1.0 0.014 15.3 1.0 5.2 5 1 0 5 5 5 0 C2H2-type zinc finger zf-C2H2 PF00096.26 EMD66064.1 - 0.029 14.8 38.1 0.075 13.5 0.1 5.6 7 0 0 7 7 7 0 Zinc finger, C2H2 type Proho_convert PF12177.8 EMD66064.1 - 0.061 13.3 0.0 0.14 12.2 0.0 1.6 1 0 0 1 1 1 0 Prohormone convertase enzyme zf_C2H2_ZHX PF18387.1 EMD66064.1 - 0.071 12.8 0.3 0.071 12.8 0.3 3.4 3 0 0 3 3 3 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-C2HE PF16278.5 EMD66064.1 - 4.1 7.9 11.3 1.4 9.4 1.7 3.5 2 1 2 4 4 4 0 C2HE / C2H2 / C2HC zinc-binding finger APH PF01636.23 EMD66065.1 - 1.6e-11 44.6 0.0 2.3e-11 44.1 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase PF00069.25 EMD66065.1 - 0.00066 19.1 0.0 0.017 14.5 0.0 2.3 3 0 0 3 3 3 1 Protein kinase domain Choline_kinase PF01633.20 EMD66065.1 - 0.0021 17.7 0.1 0.0035 17.0 0.1 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase Pox_ser-thr_kin PF05445.11 EMD66065.1 - 0.11 11.5 0.0 0.15 11.0 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Pkinase_Tyr PF07714.17 EMD66065.1 - 0.11 11.7 0.0 0.22 10.8 0.0 1.4 2 0 0 2 2 2 0 Protein tyrosine kinase Haspin_kinase PF12330.8 EMD66065.1 - 0.16 10.9 0.0 0.22 10.4 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain DUF3541 PF12060.8 EMD66066.1 - 0.064 12.9 0.1 0.086 12.5 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3541) TPD PF14811.6 EMD66066.1 - 0.077 12.9 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function TPD sequence-motif YhzD PF14120.6 EMD66066.1 - 0.52 10.5 0.0 0.52 10.5 0.0 2.3 3 1 1 4 4 4 0 YhzD-like protein bZIP_1 PF00170.21 EMD66067.1 - 1.8e-06 28.0 11.8 2e-06 27.8 11.8 1.1 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EMD66067.1 - 0.0015 18.6 13.7 0.0018 18.3 13.7 1.2 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 EMD66067.1 - 0.013 16.0 8.9 0.015 15.8 8.9 1.1 1 0 0 1 1 1 0 bZIP Maf transcription factor DHR10 PF18595.1 EMD66067.1 - 0.02 14.9 10.7 0.029 14.4 10.7 1.4 1 1 0 1 1 1 0 Designed helical repeat protein 10 domain DUF484 PF04340.12 EMD66067.1 - 0.045 13.4 4.5 0.054 13.2 4.5 1.0 1 0 0 1 1 1 0 Protein of unknown function, DUF484 DUF87 PF01935.17 EMD66067.1 - 0.1 12.7 0.9 0.12 12.5 0.9 1.0 1 0 0 1 1 1 0 Helicase HerA, central domain DUF4140 PF13600.6 EMD66067.1 - 0.31 11.5 6.4 0.44 11.0 6.4 1.2 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) V_ATPase_I PF01496.19 EMD66067.1 - 0.4 8.6 2.0 0.38 8.6 2.0 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family BRD4_CDT PF17105.5 EMD66067.1 - 0.94 9.1 13.0 0.44 10.2 10.3 1.9 1 1 1 2 2 2 0 C-terminal domain of bromodomain protein 4 DivIC PF04977.15 EMD66067.1 - 2.1 8.2 9.3 1 9.2 5.8 1.9 1 1 1 2 2 2 0 Septum formation initiator zf-MYND PF01753.18 EMD66069.1 - 1.9e-08 34.3 17.6 3.7e-08 33.3 17.3 1.7 1 1 1 2 2 2 1 MYND finger Ecl1 PF12855.7 EMD66069.1 - 0.028 15.6 2.1 0.042 15.0 2.1 1.3 1 0 0 1 1 1 0 ECL1/2/3 zinc binding proteins zf-C6H2 PF15801.5 EMD66069.1 - 0.075 13.3 12.1 0.14 12.5 12.1 1.4 1 0 0 1 1 1 0 zf-MYND-like zinc finger, mRNA-binding zf-Mss51 PF13824.6 EMD66069.1 - 2.1 8.5 8.6 4.4 7.5 8.6 1.5 1 0 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 TPR_10 PF13374.6 EMD66071.1 - 5e-24 83.4 0.7 1.5e-13 50.1 0.1 2.1 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 EMD66071.1 - 1.6e-21 76.4 0.9 1.5e-13 50.8 0.1 2.0 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 EMD66071.1 - 6.2e-05 22.8 0.4 0.036 14.1 0.0 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 EMD66071.1 - 0.00057 19.8 0.0 1.7 9.0 0.0 2.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 EMD66071.1 - 0.00067 19.7 0.0 0.032 14.4 0.0 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_4 PF07721.14 EMD66071.1 - 0.0041 17.6 0.1 0.012 16.2 0.0 1.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_20 PF14561.6 EMD66071.1 - 0.0065 16.8 0.2 0.34 11.3 0.0 2.5 1 1 2 3 3 3 1 Tetratricopeptide repeat PPR_2 PF13041.6 EMD66071.1 - 0.056 13.6 0.1 0.12 12.6 0.1 1.7 2 0 0 2 2 2 0 PPR repeat family TPR_1 PF00515.28 EMD66071.1 - 0.098 12.5 0.0 12 6.0 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat p450 PF00067.22 EMD66075.1 - 6.9e-74 249.2 0.0 8.1e-74 249.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Swi3 PF07962.12 EMD66077.1 - 0.075 13.0 0.0 1.1 9.3 0.0 2.3 2 0 0 2 2 2 0 Replication Fork Protection Component Swi3 DUF4368 PF14287.6 EMD66077.1 - 0.2 12.0 0.5 0.51 10.7 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4368) DUF4124 PF13511.6 EMD66081.1 - 6.5 7.2 8.9 8.5 6.8 8.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4124) Pkinase_fungal PF17667.1 EMD66085.1 - 1.5e-102 343.4 0.0 3.1e-102 342.4 0.0 1.5 1 1 0 1 1 1 1 Fungal protein kinase Pkinase PF00069.25 EMD66085.1 - 0.09 12.1 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 Protein kinase domain zf-3CxxC PF13695.6 EMD66086.1 - 3.9e-19 69.0 4.5 3.9e-19 69.0 4.5 3.1 2 1 0 3 3 3 1 Zinc-binding domain zf-C2H2_jaz PF12171.8 EMD66086.1 - 3.6e-05 23.9 9.2 0.00023 21.4 0.9 3.5 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EMD66086.1 - 0.00053 20.3 8.8 0.011 16.1 0.5 4.3 5 0 0 5 5 5 2 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 EMD66086.1 - 0.037 14.0 3.4 0.037 14.0 3.4 3.2 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_4 PF13894.6 EMD66086.1 - 0.065 14.1 0.4 0.065 14.1 0.4 4.5 5 0 0 5 5 5 0 C2H2-type zinc finger zf-MYST PF17772.1 EMD66086.1 - 0.27 10.9 8.5 0.56 9.9 4.1 2.7 2 0 0 2 2 2 0 MYST family zinc finger domain KASH_CCD PF14662.6 EMD66088.1 - 0.022 14.6 0.9 0.027 14.3 0.9 1.1 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH 2-Hacid_dh_C PF02826.19 EMD66095.1 - 3.2e-35 121.1 0.0 5.6e-35 120.3 0.0 1.4 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EMD66095.1 - 8.3e-21 74.1 0.0 9.9e-21 73.8 0.0 1.0 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain AlaDh_PNT_C PF01262.21 EMD66095.1 - 0.062 12.6 0.3 0.27 10.5 0.1 2.0 2 1 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain XdhC_C PF13478.6 EMD66095.1 - 0.083 13.4 0.0 2.8 8.5 0.0 2.3 2 0 0 2 2 2 0 XdhC Rossmann domain AdoHcyase_NAD PF00670.21 EMD66095.1 - 0.085 12.9 0.1 0.26 11.3 0.1 1.8 1 1 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain NAD_binding_2 PF03446.15 EMD66095.1 - 0.16 12.2 0.0 0.27 11.4 0.0 1.4 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Spt20 PF12090.8 EMD66096.1 - 1e-45 156.2 0.0 1e-45 156.2 0.0 8.0 3 1 1 4 4 4 1 Spt20 family Polyketide_cyc2 PF10604.9 EMD66097.1 - 2e-06 28.1 0.2 2.3e-06 27.9 0.2 1.1 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Bet_v_1 PF00407.19 EMD66097.1 - 0.013 15.4 0.3 0.014 15.3 0.3 1.1 1 0 0 1 1 1 0 Pathogenesis-related protein Bet v I family HSP20 PF00011.21 EMD66098.1 - 9e-13 48.3 0.1 1.3e-12 47.7 0.1 1.3 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 EMD66098.1 - 0.00028 20.4 0.1 0.0014 18.1 0.1 2.0 1 1 0 1 1 1 1 HSP20-like domain found in ArsA GMC_oxred_N PF00732.19 EMD66099.1 - 6.9e-46 157.0 0.0 8.5e-46 156.7 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EMD66099.1 - 1.9e-30 106.3 0.0 4.3e-30 105.1 0.0 1.6 1 0 0 1 1 1 1 GMC oxidoreductase Lycopene_cycl PF05834.12 EMD66099.1 - 0.038 13.0 0.1 0.062 12.3 0.1 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein NAD_binding_8 PF13450.6 EMD66099.1 - 0.051 13.8 0.1 0.18 12.1 0.1 2.0 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Trp_halogenase PF04820.14 EMD66099.1 - 0.2 10.4 0.0 0.3 9.9 0.0 1.2 1 0 0 1 1 1 0 Tryptophan halogenase AstE_AspA PF04952.14 EMD66101.1 - 2.1e-33 115.7 0.0 2.5e-33 115.4 0.0 1.1 1 0 0 1 1 1 1 Succinylglutamate desuccinylase / Aspartoacylase family Thiamine_BP PF01910.17 EMD66101.1 - 0.063 13.2 0.1 0.17 11.8 0.1 1.7 1 0 0 1 1 1 0 Thiamine-binding protein Peptidase_M23 PF01551.22 EMD66101.1 - 0.082 13.1 0.0 0.29 11.4 0.0 1.9 1 1 0 1 1 1 0 Peptidase family M23 Ank_2 PF12796.7 EMD66102.1 - 4.9e-09 36.6 0.5 2.3e-05 24.9 0.1 2.7 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMD66102.1 - 9.3e-08 32.5 0.0 0.027 15.1 0.0 4.1 3 1 2 5 5 5 2 Ankyrin repeats (many copies) Ank PF00023.30 EMD66102.1 - 2e-07 31.1 4.7 0.027 14.9 0.0 4.0 5 0 0 5 5 5 2 Ankyrin repeat Ank_3 PF13606.6 EMD66102.1 - 4.9e-05 23.4 0.0 0.79 10.5 0.0 3.5 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 EMD66102.1 - 0.016 15.5 0.0 10 6.6 0.0 3.5 3 0 0 3 3 3 0 Ankyrin repeats (many copies) HET PF06985.11 EMD66103.1 - 8.9e-38 129.9 5.1 1.4e-37 129.3 5.1 1.3 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) OMPdecase PF00215.24 EMD66105.1 - 1e-78 264.0 0.0 1.2e-78 263.8 0.0 1.1 1 0 0 1 1 1 1 Orotidine 5'-phosphate decarboxylase / HUMPS family ORC6 PF05460.13 EMD66106.1 - 1.2 8.3 8.6 1.4 8.1 8.6 1.1 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) SDA1 PF05285.12 EMD66107.1 - 1.7e-91 307.3 31.4 1.7e-91 307.3 31.4 2.2 2 0 0 2 2 2 2 SDA1 NUC130_3NT PF08158.12 EMD66107.1 - 2.2e-19 69.5 0.3 1.2e-18 67.1 0.1 2.4 2 0 0 2 2 2 1 NUC130/3NT domain MMS1_N PF10433.9 EMD66108.1 - 2.5e-128 428.8 0.0 4.8e-128 427.8 0.0 1.5 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 EMD66108.1 - 2.8e-85 286.5 0.0 1.6e-84 284.0 0.0 2.2 3 0 0 3 3 3 1 CPSF A subunit region EthD PF07110.11 EMD66109.1 - 2e-08 35.2 1.0 3.4e-08 34.5 1.0 1.4 1 1 0 1 1 1 1 EthD domain bZIP_1 PF00170.21 EMD66112.1 - 3.9e-07 30.1 12.6 5e-07 29.7 10.5 2.2 2 0 0 2 2 2 1 bZIP transcription factor Spt20 PF12090.8 EMD66112.1 - 0.17 11.5 16.6 0.48 10.0 16.6 1.9 1 0 0 1 1 1 0 Spt20 family PPR_2 PF13041.6 EMD66113.1 - 9.3e-36 121.8 0.8 1.1e-08 35.1 0.0 8.8 6 2 3 9 9 9 7 PPR repeat family PPR_3 PF13812.6 EMD66113.1 - 4.4e-23 81.1 0.0 1.6e-08 34.5 0.0 6.0 5 1 1 6 6 6 5 Pentatricopeptide repeat domain PPR PF01535.20 EMD66113.1 - 4.1e-22 76.8 7.2 0.00019 21.4 0.0 7.6 8 0 0 8 8 8 5 PPR repeat PPR_long PF17177.4 EMD66113.1 - 3.4e-15 56.0 0.2 0.00017 21.1 0.0 3.6 2 1 1 3 3 3 3 Pentacotripeptide-repeat region of PRORP PPR_1 PF12854.7 EMD66113.1 - 1.8e-09 37.1 1.6 0.00086 19.0 0.0 5.9 7 0 0 7 7 7 1 PPR repeat TPR_14 PF13428.6 EMD66113.1 - 0.011 16.4 3.6 7.8 7.6 0.1 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat MRP-S27 PF10037.9 EMD66113.1 - 0.055 12.3 0.5 5.5 5.7 0.0 3.4 4 0 0 4 4 4 0 Mitochondrial 28S ribosomal protein S27 Exog_C PF18026.1 EMD66113.1 - 0.073 13.1 2.0 7 6.8 0.1 4.3 4 1 1 5 5 5 0 Endo/exonuclease (EXOG) C-terminal domain His_Phos_2 PF00328.22 EMD66114.1 - 3.2e-12 46.5 0.0 1.7e-11 44.2 0.0 1.9 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) PhoD PF09423.10 EMD66115.1 - 2e-115 385.6 4.0 2.5e-115 385.2 4.0 1.1 1 0 0 1 1 1 1 PhoD-like phosphatase PhoD_N PF16655.5 EMD66115.1 - 2.1e-33 114.7 0.2 5.8e-33 113.3 0.2 1.8 1 0 0 1 1 1 1 PhoD-like phosphatase, N-terminal domain Pur_ac_phosph_N PF16656.5 EMD66115.1 - 0.0044 17.6 2.3 0.0044 17.6 2.3 2.1 2 0 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain Glyco_hydro_12 PF01670.16 EMD66116.1 - 6.8e-47 160.2 6.6 7.9e-47 160.0 6.6 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 12 Phage_holin_5_1 PF06946.11 EMD66116.1 - 0.039 14.3 5.6 0.13 12.7 0.4 2.8 2 1 1 3 3 3 0 Bacteriophage A118-like holin, Hol118 F-box PF00646.33 EMD66117.1 - 0.11 12.4 0.1 1.1 9.2 0.0 2.5 2 0 0 2 2 2 0 F-box domain DUF2673 PF10880.8 EMD66118.1 - 1.5 9.0 9.0 0.46 10.6 0.3 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2673) CHRD PF07452.12 EMD66119.1 - 6.5e-14 52.9 0.1 1e-13 52.3 0.1 1.3 1 0 0 1 1 1 1 CHRD domain DUF4710 PF15828.5 EMD66122.1 - 0.074 13.2 4.2 0.097 12.8 4.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4710) TAF4 PF05236.14 EMD66123.1 - 1.1e-35 123.8 0.0 4.6e-27 95.5 0.0 2.2 2 0 0 2 2 2 2 Transcription initiation factor TFIID component TAF4 family CPSF73-100_C PF11718.8 EMD66124.1 - 1.8e-79 266.3 0.0 3.6e-79 265.3 0.0 1.5 2 0 0 2 2 2 1 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term Beta-Casp PF10996.8 EMD66124.1 - 2.2e-32 111.6 0.0 4.3e-32 110.7 0.0 1.5 1 0 0 1 1 1 1 Beta-Casp domain Lactamase_B PF00753.27 EMD66124.1 - 2.7e-18 66.7 0.1 5.2e-18 65.8 0.1 1.6 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_6 PF16661.5 EMD66124.1 - 7.9e-17 61.3 0.1 1.4e-16 60.6 0.1 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain RMMBL PF07521.12 EMD66124.1 - 1e-11 44.5 0.0 2.4e-11 43.4 0.0 1.6 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B_2 PF12706.7 EMD66124.1 - 2.7e-05 23.8 0.4 0.00066 19.2 0.3 2.4 2 0 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 EMD66124.1 - 4.6e-05 23.4 0.1 0.00017 21.5 0.1 2.0 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Mito_carr PF00153.27 EMD66125.1 - 3.2e-44 148.8 9.5 1.2e-16 60.4 0.5 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein SUR7 PF06687.12 EMD66126.1 - 0.027 14.1 0.0 0.03 13.9 0.0 1.1 1 0 0 1 1 1 0 SUR7/PalI family HemY_N PF07219.13 EMD66126.1 - 1.8 8.8 5.3 6.9 6.9 3.8 2.0 2 0 0 2 2 2 0 HemY protein N-terminus HSP70 PF00012.20 EMD66127.1 - 2.2e-11 42.7 0.3 1e-09 37.2 0.1 2.0 2 0 0 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.13 EMD66127.1 - 0.034 13.0 0.1 0.2 10.4 0.0 1.9 2 0 0 2 2 2 0 MreB/Mbl protein MFS_1 PF07690.16 EMD66128.1 - 9.9e-23 80.6 16.7 9.9e-23 80.6 16.7 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EMD66128.1 - 1.7e-07 30.5 2.5 1.7e-07 30.5 2.5 1.7 2 0 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 EMD66128.1 - 0.036 12.5 0.3 0.052 12.0 0.3 1.2 1 0 0 1 1 1 0 Fungal trichothecene efflux pump (TRI12) Glt_symporter PF03616.14 EMD66128.1 - 0.13 10.9 0.1 0.25 10.0 0.1 1.5 1 0 0 1 1 1 0 Sodium/glutamate symporter MIF PF01187.18 EMD66130.1 - 3.3e-13 49.9 0.0 5.7e-13 49.2 0.0 1.4 1 0 0 1 1 1 1 Macrophage migration inhibitory factor (MIF) CENP-X PF09415.10 EMD66131.1 - 5.5e-22 77.9 0.0 8.9e-22 77.2 0.0 1.3 1 0 0 1 1 1 1 CENP-S associating Centromere protein X Copper-bind PF00127.20 EMD66132.1 - 0.0028 18.0 0.2 0.0046 17.4 0.2 1.3 1 0 0 1 1 1 1 Copper binding proteins, plastocyanin/azurin family Cu_bind_like PF02298.17 EMD66132.1 - 0.015 15.3 0.6 0.082 12.9 0.6 1.9 1 1 0 1 1 1 0 Plastocyanin-like domain HET PF06985.11 EMD66134.1 - 0.0044 17.4 0.3 0.0062 16.9 0.3 1.3 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) APH PF01636.23 EMD66135.1 - 5.6e-09 36.3 0.1 2.5e-08 34.1 0.0 1.9 2 0 0 2 2 2 1 Phosphotransferase enzyme family DUF1679 PF07914.11 EMD66135.1 - 0.0077 15.1 0.0 0.011 14.7 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1679) ABATE PF07336.11 EMD66135.1 - 0.024 15.3 0.5 0.078 13.6 0.1 2.1 2 0 0 2 2 2 0 Putative stress-induced transcription regulator Choline_kinase PF01633.20 EMD66135.1 - 0.075 12.6 0.0 0.12 11.9 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase LigB PF02900.18 EMD66137.1 - 1.6e-32 112.6 0.0 1.9e-32 112.4 0.0 1.0 1 0 0 1 1 1 1 Catalytic LigB subunit of aromatic ring-opening dioxygenase Cu-oxidase_2 PF07731.14 EMD66138.1 - 4e-45 152.9 6.1 3.4e-41 140.2 0.2 3.5 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase_3 PF07732.15 EMD66138.1 - 3.5e-44 149.6 8.4 1.6e-42 144.3 1.6 3.9 5 0 0 5 5 5 2 Multicopper oxidase Cu-oxidase PF00394.22 EMD66138.1 - 1.1e-36 126.4 2.1 2.4e-34 118.8 0.3 3.1 3 0 0 3 3 3 2 Multicopper oxidase Cupredoxin_1 PF13473.6 EMD66138.1 - 0.0069 16.5 0.0 14 5.9 0.0 3.8 4 1 0 4 4 4 1 Cupredoxin-like domain Monooxygenase_B PF04744.12 EMD66138.1 - 0.065 12.1 0.6 0.12 11.2 0.0 1.7 2 0 0 2 2 2 0 Monooxygenase subunit B protein FTR1 PF03239.14 EMD66139.1 - 1.1e-85 287.5 8.7 1.3e-85 287.2 8.7 1.0 1 0 0 1 1 1 1 Iron permease FTR1 family DUF3087 PF11286.8 EMD66139.1 - 0.1 12.0 0.0 0.19 11.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3087) B12D PF06522.11 EMD66139.1 - 0.87 9.4 2.4 2 8.3 0.2 2.5 2 0 0 2 2 2 0 NADH-ubiquinone reductase complex 1 MLRQ subunit DUF1218 PF06749.12 EMD66139.1 - 2.9 8.5 14.7 18 5.9 0.1 4.2 2 1 2 4 4 4 0 Protein of unknown function (DUF1218) CDP-OH_P_transf PF01066.21 EMD66141.1 - 1.3e-13 51.5 0.1 1.3e-13 51.5 0.1 2.2 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase DEAD PF00270.29 EMD66142.1 - 2.2e-49 167.6 0.2 5.3e-49 166.4 0.2 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EMD66142.1 - 3.3e-31 107.9 0.2 1.9e-28 99.0 0.1 2.8 2 0 0 2 2 2 2 Helicase conserved C-terminal domain UTP25 PF06862.12 EMD66142.1 - 0.00082 18.3 0.8 0.00082 18.3 0.8 1.8 2 1 0 2 2 2 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 MCPsignal PF00015.21 EMD66142.1 - 0.0028 17.5 1.4 0.0028 17.5 1.4 1.8 2 0 0 2 2 2 1 Methyl-accepting chemotaxis protein (MCP) signalling domain AAA_22 PF13401.6 EMD66142.1 - 0.03 14.6 0.0 0.082 13.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain LppX_LprAFG PF07161.13 EMD66143.1 - 0.25 11.2 0.0 0.34 10.7 0.0 1.1 1 0 0 1 1 1 0 LppX_LprAFG lipoprotein Amidohydro_2 PF04909.14 EMD66144.1 - 1.7e-22 80.5 0.0 2.4e-22 80.1 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase MFS_1 PF07690.16 EMD66147.1 - 6.1e-10 38.6 11.8 1.5e-09 37.3 11.8 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily ALG11_N PF15924.5 EMD66147.1 - 0.47 10.5 2.5 0.42 10.6 0.7 1.7 2 0 0 2 2 2 0 ALG11 mannosyltransferase N-terminus FAD_binding_3 PF01494.19 EMD66148.1 - 1.5e-05 24.4 1.4 0.29 10.3 0.1 3.1 3 0 0 3 3 3 3 FAD binding domain Pyr_redox PF00070.27 EMD66148.1 - 0.017 15.6 0.0 0.036 14.6 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Peptidase_S9 PF00326.21 EMD66148.1 - 0.018 14.5 0.0 0.031 13.7 0.0 1.4 1 0 0 1 1 1 0 Prolyl oligopeptidase family NAD_binding_8 PF13450.6 EMD66148.1 - 0.05 13.8 0.0 0.21 11.8 0.0 2.1 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EMD66148.1 - 0.15 11.2 0.0 0.25 10.5 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase PDZ_1 PF12812.7 EMD66149.1 - 2.7e-60 200.3 0.0 3.5e-36 123.1 0.0 2.6 2 0 0 2 2 2 2 PDZ-like domain Trypsin_2 PF13365.6 EMD66149.1 - 3.6e-25 89.6 0.4 3.3e-22 80.0 0.1 2.6 2 0 0 2 2 2 2 Trypsin-like peptidase domain PDZ_2 PF13180.6 EMD66149.1 - 4.1e-13 49.4 1.9 1e-06 28.9 0.1 3.9 4 0 0 4 4 4 2 PDZ domain PDZ_6 PF17820.1 EMD66149.1 - 2.4e-12 46.5 0.1 4.7e-06 26.3 0.3 4.3 4 0 0 4 4 4 3 PDZ domain PDZ PF00595.24 EMD66149.1 - 3.2e-10 40.2 0.0 0.00014 22.2 0.0 3.7 3 0 0 3 3 3 2 PDZ domain Trypsin PF00089.26 EMD66149.1 - 0.00028 20.7 0.0 0.00085 19.2 0.0 1.8 1 1 0 1 1 1 1 Trypsin Tricorn_PDZ PF14685.6 EMD66149.1 - 0.0015 18.4 0.9 0.16 12.0 0.1 3.2 3 0 0 3 3 3 1 Tricorn protease PDZ domain Peptidase_S46 PF10459.9 EMD66149.1 - 0.064 11.9 0.0 0.13 10.9 0.0 1.4 1 0 0 1 1 1 0 Peptidase S46 DUF31 PF01732.16 EMD66149.1 - 0.2 11.2 0.2 0.35 10.3 0.2 1.4 1 0 0 1 1 1 0 Putative peptidase (DUF31) Striatin PF08232.12 EMD66150.1 - 0.039 14.5 8.2 0.044 14.4 8.2 1.1 1 0 0 1 1 1 0 Striatin family DUF2407_C PF13373.6 EMD66150.1 - 0.1 12.7 0.2 0.14 12.4 0.2 1.1 1 0 0 1 1 1 0 DUF2407 C-terminal domain Connexin PF00029.19 EMD66150.1 - 0.12 12.1 0.4 0.15 11.8 0.4 1.1 1 0 0 1 1 1 0 Connexin GNAT_acetyltr_2 PF13718.6 EMD66150.1 - 0.28 10.6 2.0 0.3 10.4 2.0 1.2 1 0 0 1 1 1 0 GNAT acetyltransferase 2 DUF3560 PF12083.8 EMD66150.1 - 0.44 10.7 6.3 1.3 9.1 0.9 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF3560) CutC PF03932.14 EMD66151.1 - 1.4e-58 197.7 0.0 1.6e-58 197.5 0.0 1.0 1 0 0 1 1 1 1 CutC family DHO_dh PF01180.21 EMD66151.1 - 0.034 13.4 0.5 0.034 13.4 0.5 1.5 2 0 0 2 2 2 0 Dihydroorotate dehydrogenase DUF2183 PF09949.9 EMD66153.1 - 1.9e-21 76.3 0.1 4.3e-21 75.1 0.1 1.6 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2183) Amidase PF01425.21 EMD66154.1 - 8.4e-65 219.5 0.0 1.1e-64 219.1 0.0 1.1 1 0 0 1 1 1 1 Amidase Isochorismatase PF00857.20 EMD66154.1 - 3.6e-35 121.7 0.0 1.7e-34 119.5 0.0 1.9 2 0 0 2 2 2 1 Isochorismatase family Transp_cyt_pur PF02133.15 EMD66155.1 - 1.2e-64 218.7 25.9 1.5e-64 218.4 25.9 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin T3SS_needle_E PF08988.10 EMD66156.1 - 0.027 14.6 1.0 0.027 14.6 1.0 2.6 2 1 0 2 2 2 0 Type III secretion system, cytoplasmic E component of needle RIH_assoc PF08454.11 EMD66156.1 - 0.15 12.0 1.1 0.2 11.5 1.1 1.4 1 1 0 1 1 1 0 RyR and IP3R Homology associated DUF1977 PF09320.11 EMD66156.1 - 2.4 8.4 5.6 0.58 10.5 2.0 1.9 2 1 0 2 2 2 0 Domain of unknown function (DUF1977) DVL PF08137.12 EMD66157.1 - 9.6 6.2 6.1 20 5.1 0.6 2.5 2 0 0 2 2 2 0 DVL family SET PF00856.28 EMD66158.1 - 0.0057 17.1 0.0 0.039 14.3 0.0 2.1 1 1 0 1 1 1 1 SET domain IR1-M PF12185.8 EMD66158.1 - 0.021 14.7 0.1 0.038 13.9 0.1 1.3 1 0 0 1 1 1 0 Nup358/RanBP2 E3 ligase domain Arginase PF00491.21 EMD66163.1 - 1.3e-76 257.8 0.2 1.5e-76 257.5 0.2 1.0 1 0 0 1 1 1 1 Arginase family DUF167 PF02594.16 EMD66164.1 - 1.2e-21 76.6 1.2 1.2e-21 76.6 1.2 1.5 2 0 0 2 2 2 1 Uncharacterised ACR, YggU family COG1872 WD40 PF00400.32 EMD66166.1 - 1.5e-09 38.3 5.9 0.5 11.3 0.0 5.1 5 0 0 5 5 5 4 WD domain, G-beta repeat Nup160 PF11715.8 EMD66166.1 - 0.034 12.8 0.1 4.5 5.8 0.1 2.7 2 1 1 3 3 3 0 Nucleoporin Nup120/160 COQ9 PF08511.11 EMD66167.1 - 3.5e-33 113.2 0.1 5.6e-33 112.5 0.1 1.4 1 0 0 1 1 1 1 COQ9 FRQ PF09421.10 EMD66168.1 - 1.1e-130 437.5 51.7 3.6e-130 435.8 51.8 1.8 1 1 0 1 1 1 1 Frequency clock protein SCP1201-deam PF14428.6 EMD66168.1 - 3.8 7.4 9.6 0.14 12.0 0.8 2.8 3 0 0 3 3 3 0 SCP1.201-like deaminase Pyr_redox_2 PF07992.14 EMD66169.1 - 2.2e-40 138.7 0.2 8.7e-37 126.9 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EMD66169.1 - 2.3e-12 47.3 0.0 2e-09 37.8 0.0 2.6 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EMD66169.1 - 0.039 13.5 0.3 15 5.0 0.0 3.3 2 1 1 3 3 3 0 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EMD66169.1 - 0.044 14.0 0.0 2.5 8.4 0.0 2.6 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain CytB6-F_Fe-S PF08802.10 EMD66169.1 - 0.14 12.3 0.0 0.45 10.6 0.0 1.9 1 0 0 1 1 1 0 Cytochrome B6-F complex Fe-S subunit Coiled PF05710.12 EMD66169.1 - 0.4 11.5 10.5 0.84 10.5 10.5 1.6 1 0 0 1 1 1 0 Coiled coil Mis14 PF08641.12 EMD66170.1 - 5.8e-13 49.3 4.0 6.7e-13 49.1 2.8 1.7 2 1 0 2 2 2 1 Kinetochore protein Mis14 like DUF2884 PF11101.8 EMD66170.1 - 0.064 12.8 0.2 0.2 11.1 0.0 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2884) DUF3984 PF13136.6 EMD66171.1 - 0.83 9.0 13.2 1.1 8.5 13.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3984) RasGAP PF00616.19 EMD66172.1 - 1.5e-60 204.4 0.1 1.5e-60 204.4 0.1 2.0 3 0 0 3 3 3 1 GTPase-activator protein for Ras-like GTPase RasGAP_C PF03836.15 EMD66172.1 - 1.6e-29 102.8 2.4 1.6e-29 102.8 2.4 2.7 3 0 0 3 3 3 1 RasGAP C-terminus K_channel_TID PF07941.11 EMD66173.1 - 0.052 14.0 1.8 0.14 12.7 1.8 1.6 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain Pyrid_ox_like PF16242.5 EMD66174.1 - 4.7e-23 81.4 0.0 6.7e-23 80.9 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase like Putative_PNPOx PF01243.20 EMD66174.1 - 1.6e-06 28.2 0.0 2.7e-06 27.5 0.0 1.3 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase ABC_tran_CTD PF16326.5 EMD66175.1 - 0.002 18.3 7.7 0.002 18.3 7.7 6.5 4 3 3 7 7 7 3 ABC transporter C-terminal domain GIT_CC PF16559.5 EMD66175.1 - 0.76 9.7 10.8 4.9 7.1 0.1 4.4 3 1 1 4 4 4 0 GIT coiled-coil Rho guanine nucleotide exchange factor HEM4 PF02602.15 EMD66176.1 - 1.7e-41 142.1 0.0 3.5e-41 141.1 0.0 1.4 1 1 0 1 1 1 1 Uroporphyrinogen-III synthase HemD Macoilin PF09726.9 EMD66176.1 - 3.9 5.9 9.5 5.2 5.5 9.5 1.1 1 0 0 1 1 1 0 Macoilin family PAP2 PF01569.21 EMD66177.1 - 7.4e-23 80.8 4.9 7.4e-23 80.8 4.9 1.6 2 0 0 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.6 EMD66177.1 - 2 8.1 13.6 0.087 12.5 0.7 3.0 2 1 0 2 2 2 0 PAP2 superfamily Polysacc_synt_C PF14667.6 EMD66177.1 - 4.9 7.2 10.7 0.49 10.5 1.4 2.5 3 0 0 3 3 3 0 Polysaccharide biosynthesis C-terminal domain Glyco_hyd_65N_2 PF14498.6 EMD66178.1 - 4e-53 180.7 0.1 6.1e-53 180.1 0.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, N-terminal domain Glyco_hydro_65m PF03632.15 EMD66178.1 - 0.0025 16.7 0.0 0.0042 16.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 65 central catalytic domain zf-Mss51 PF13824.6 EMD66179.1 - 2e-29 101.5 7.7 4.6e-29 100.3 7.7 1.7 1 0 0 1 1 1 1 Zinc-finger of mitochondrial splicing suppressor 51 zf-MYND PF01753.18 EMD66179.1 - 0.32 11.1 6.1 0.071 13.2 2.4 1.8 2 0 0 2 2 2 0 MYND finger DNA_pol_A_exo1 PF01612.20 EMD66180.1 - 0.026 14.2 0.0 0.03 14.1 0.0 1.2 1 0 0 1 1 1 0 3'-5' exonuclease NmrA PF05368.13 EMD66182.1 - 1.7e-43 148.9 0.0 2.4e-43 148.4 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family adh_short PF00106.25 EMD66182.1 - 4.6e-30 104.5 0.2 1.5e-26 93.1 0.0 2.2 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EMD66182.1 - 8.6e-24 84.4 0.0 7.8e-21 74.7 0.0 2.2 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.6 EMD66182.1 - 1.1e-13 51.5 0.0 6.7e-13 48.9 0.1 2.0 2 0 0 2 2 2 1 NAD(P)H-binding Epimerase PF01370.21 EMD66182.1 - 0.0002 20.9 0.1 0.00052 19.6 0.0 1.7 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family TrkA_N PF02254.18 EMD66182.1 - 0.0019 18.5 0.0 0.0033 17.7 0.0 1.4 1 0 0 1 1 1 1 TrkA-N domain 3Beta_HSD PF01073.19 EMD66182.1 - 0.016 14.2 0.0 0.025 13.6 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Semialdhyde_dh PF01118.24 EMD66182.1 - 0.035 14.5 0.2 0.15 12.5 0.1 2.0 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain CobT PF06213.12 EMD66184.1 - 0.0016 17.9 8.8 0.002 17.5 8.8 1.1 1 0 0 1 1 1 1 Cobalamin biosynthesis protein CobT RR_TM4-6 PF06459.12 EMD66184.1 - 0.066 13.0 10.1 0.07 12.9 10.1 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Pox_Ag35 PF03286.14 EMD66184.1 - 0.23 11.2 7.4 0.28 11.0 7.4 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein TRAP_alpha PF03896.16 EMD66184.1 - 0.52 9.5 4.3 0.74 9.0 4.3 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit CDC45 PF02724.14 EMD66184.1 - 0.61 8.3 14.7 0.7 8.1 14.7 1.0 1 0 0 1 1 1 0 CDC45-like protein NPR3 PF03666.13 EMD66184.1 - 0.8 8.4 6.2 0.91 8.2 6.2 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Presenilin PF01080.17 EMD66184.1 - 0.82 8.4 7.0 0.92 8.2 7.0 1.1 1 0 0 1 1 1 0 Presenilin Neur_chan_memb PF02932.16 EMD66184.1 - 0.96 9.4 3.7 1.1 9.3 3.7 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Astro_capsid_p PF12226.8 EMD66184.1 - 1.1 8.3 8.6 1.4 8.0 8.6 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Zip PF02535.22 EMD66184.1 - 1.8 7.7 14.6 2.2 7.4 14.6 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter SelP_N PF04592.14 EMD66184.1 - 8.2 5.8 25.6 13 5.1 25.6 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region PAF-AH_p_II PF03403.13 EMD66185.1 - 0.00031 19.4 0.0 0.00044 18.9 0.0 1.3 1 0 0 1 1 1 1 Platelet-activating factor acetylhydrolase, isoform II Acetyltransf_10 PF13673.7 EMD66186.1 - 0.00015 21.7 0.0 0.09 12.7 0.0 2.5 1 1 1 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EMD66186.1 - 0.0011 19.4 0.0 0.0022 18.4 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EMD66186.1 - 0.0019 18.4 0.0 0.0042 17.3 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_5 PF13444.6 EMD66186.1 - 0.039 14.7 0.0 0.14 12.9 0.0 2.0 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain GMC_oxred_N PF00732.19 EMD66187.1 - 1.4e-45 156.0 0.9 1.2e-44 152.9 0.4 2.1 2 0 0 2 2 2 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EMD66187.1 - 4e-28 98.7 0.1 2.8e-27 96.0 0.0 2.4 3 0 0 3 3 3 1 GMC oxidoreductase FAD_binding_2 PF00890.24 EMD66187.1 - 1.7e-07 30.7 0.4 6.5e-05 22.2 0.4 2.3 2 0 0 2 2 2 2 FAD binding domain FAD_binding_3 PF01494.19 EMD66187.1 - 0.00013 21.3 0.0 0.0002 20.7 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EMD66187.1 - 0.00038 19.8 0.1 0.0019 17.5 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EMD66187.1 - 0.0023 18.1 0.4 0.0077 16.4 0.1 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 EMD66187.1 - 0.0035 16.8 0.2 0.026 13.9 0.2 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.17 EMD66187.1 - 0.024 13.9 0.1 0.085 12.1 0.1 1.8 2 0 0 2 2 2 0 Thi4 family DAO PF01266.24 EMD66187.1 - 0.058 13.0 0.6 1.1 8.8 0.2 2.3 2 0 0 2 2 2 0 FAD dependent oxidoreductase HI0933_like PF03486.14 EMD66187.1 - 0.14 10.8 0.1 0.22 10.2 0.1 1.3 1 0 0 1 1 1 0 HI0933-like protein Herpes_UL95 PF03038.14 EMD66188.1 - 0.019 14.1 0.2 0.026 13.7 0.2 1.3 1 0 0 1 1 1 0 UL95 family Metallothio_Euk PF12749.7 EMD66188.1 - 1.5 9.0 17.7 2.9 8.1 1.3 3.3 3 0 0 3 3 3 0 Eukaryotic metallothionein FYVE PF01363.21 EMD66189.1 - 9.9e-14 51.2 11.9 1.6e-13 50.6 11.9 1.3 1 0 0 1 1 1 1 FYVE zinc finger zf-AN1 PF01428.16 EMD66189.1 - 0.023 14.9 7.8 0.023 14.9 7.8 2.2 2 0 0 2 2 2 0 AN1-like Zinc finger IBR PF01485.21 EMD66189.1 - 0.045 14.0 3.0 0.045 14.0 3.0 1.9 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain G_path_suppress PF15991.5 EMD66189.1 - 0.48 10.5 9.0 0.83 9.7 9.0 1.4 1 0 0 1 1 1 0 G-protein pathway suppressor Dus PF01207.17 EMD66190.1 - 1.6e-54 185.1 0.0 3e-54 184.2 0.0 1.4 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) DHO_dh PF01180.21 EMD66190.1 - 0.007 15.6 0.0 0.015 14.5 0.0 1.5 2 0 0 2 2 2 1 Dihydroorotate dehydrogenase BKACE PF05853.12 EMD66190.1 - 0.11 11.8 0.0 0.22 10.8 0.0 1.4 1 0 0 1 1 1 0 beta-keto acid cleavage enzyme DUF5082 PF16888.5 EMD66191.1 - 0.11 12.8 1.3 0.16 12.2 1.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5082) DUF3626 PF12294.8 EMD66191.1 - 0.12 11.4 0.0 0.16 11.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3626) Zn_clus PF00172.18 EMD66192.1 - 2.1e-05 24.5 10.2 3.6e-05 23.8 10.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain GMC_oxred_N PF00732.19 EMD66193.1 - 6.8e-27 94.6 0.0 1.1e-26 93.9 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EMD66193.1 - 2.6e-17 63.7 0.0 5.2e-17 62.7 0.0 1.5 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.24 EMD66193.1 - 1.3e-07 31.1 0.3 2.4e-06 26.9 0.2 2.1 2 0 0 2 2 2 1 FAD binding domain HI0933_like PF03486.14 EMD66193.1 - 4.8e-07 28.8 0.0 0.00013 20.8 0.0 2.1 2 0 0 2 2 2 2 HI0933-like protein Pyr_redox_2 PF07992.14 EMD66193.1 - 1.2e-06 27.9 0.0 0.00029 20.2 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EMD66193.1 - 2.1e-05 24.1 0.2 4.7e-05 22.9 0.1 1.6 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 EMD66193.1 - 3.2e-05 23.3 0.0 6.1e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 EMD66193.1 - 0.00039 20.6 0.0 0.001 19.3 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EMD66193.1 - 0.00097 18.8 0.5 1.1 8.8 0.5 2.8 3 1 1 4 4 4 2 FAD dependent oxidoreductase GIDA PF01134.22 EMD66193.1 - 0.0048 16.0 0.1 0.0075 15.4 0.1 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A Pyr_redox PF00070.27 EMD66193.1 - 0.0062 17.1 0.1 5.6 7.6 0.0 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EMD66193.1 - 0.0097 15.2 0.1 0.12 11.6 0.1 2.3 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EMD66193.1 - 0.013 14.6 0.0 0.02 14.0 0.0 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein Thi4 PF01946.17 EMD66193.1 - 0.017 14.3 0.0 0.031 13.5 0.0 1.3 1 0 0 1 1 1 0 Thi4 family SpoIIID PF12116.8 EMD66194.1 - 0.013 15.6 0.1 0.016 15.3 0.1 1.2 1 0 0 1 1 1 0 Stage III sporulation protein D HTH_psq PF05225.16 EMD66194.1 - 0.016 15.0 0.1 0.024 14.3 0.1 1.3 1 0 0 1 1 1 0 helix-turn-helix, Psq domain HTH_23 PF13384.6 EMD66194.1 - 0.036 13.9 0.0 0.056 13.3 0.0 1.3 1 0 0 1 1 1 0 Homeodomain-like domain HTH_7 PF02796.15 EMD66194.1 - 0.063 13.4 0.0 0.1 12.7 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain of resolvase CRAL_TRIO_2 PF13716.6 EMD66194.1 - 0.083 13.0 0.0 0.094 12.9 0.0 1.2 1 0 0 1 1 1 0 Divergent CRAL/TRIO domain CENP-B_N PF04218.13 EMD66194.1 - 0.12 12.0 0.0 0.19 11.4 0.0 1.3 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain PTR2 PF00854.21 EMD66196.1 - 2e-85 287.0 8.0 3.2e-85 286.4 8.0 1.3 1 0 0 1 1 1 1 POT family DUF1772 PF08592.11 EMD66196.1 - 0.024 15.0 1.1 0.064 13.6 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1772) Helicase_C_2 PF13307.6 EMD66197.1 - 2.7e-55 187.2 0.0 8.4e-55 185.5 0.0 1.9 1 0 0 1 1 1 1 Helicase C-terminal domain DEAD_2 PF06733.15 EMD66197.1 - 9.8e-48 162.1 0.0 1.9e-47 161.1 0.0 1.5 1 0 0 1 1 1 1 DEAD_2 ResIII PF04851.15 EMD66197.1 - 0.0015 18.6 0.1 2 8.4 0.1 2.9 2 1 0 2 2 2 2 Type III restriction enzyme, res subunit PhoH PF02562.16 EMD66197.1 - 0.046 13.2 0.0 17 4.8 0.0 3.0 3 0 0 3 3 3 0 PhoH-like protein DEAD PF00270.29 EMD66197.1 - 0.073 12.8 0.0 8.7 6.1 0.0 2.4 2 0 0 2 2 2 0 DEAD/DEAH box helicase MOZ_SAS PF01853.18 EMD66198.1 - 1.4e-66 223.6 0.0 2.6e-66 222.7 0.0 1.4 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 EMD66198.1 - 6e-16 57.8 0.0 1.3e-15 56.7 0.0 1.6 1 0 0 1 1 1 1 MYST family zinc finger domain BTB PF00651.31 EMD66198.1 - 5.7e-07 29.7 0.0 1.8e-06 28.1 0.0 1.8 1 1 0 1 1 1 1 BTB/POZ domain Acetyltransf_7 PF13508.7 EMD66198.1 - 0.021 15.3 0.0 0.054 13.9 0.0 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EMD66198.1 - 0.023 14.9 0.0 0.25 11.6 0.0 2.4 2 0 0 2 2 2 0 Acetyltransferase (GNAT) family MoaC PF01967.21 EMD66199.1 - 4.5e-49 166.0 0.3 7.8e-49 165.3 0.3 1.4 1 0 0 1 1 1 1 MoaC family V_ATPase_I PF01496.19 EMD66199.1 - 0.0092 14.0 9.0 0.014 13.3 9.0 1.2 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family Nup88 PF10168.9 EMD66199.1 - 0.29 8.9 19.7 0.35 8.6 5.7 2.1 2 0 0 2 2 2 0 Nuclear pore component DUF4677 PF15726.5 EMD66199.1 - 0.3 11.2 5.4 0.64 10.2 0.0 3.5 4 0 0 4 4 4 0 Domain of unknown function (DUF4677) NPV_P10 PF05531.12 EMD66199.1 - 1.6 9.2 7.2 5.3 7.6 3.1 3.3 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF4570 PF15134.6 EMD66199.1 - 1.9 8.6 12.5 0.15 12.1 3.5 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4570) AAA_23 PF13476.6 EMD66199.1 - 6.4 7.2 22.5 4.7 7.7 6.5 2.5 2 0 0 2 2 2 0 AAA domain Mob_synth_C PF06463.13 EMD66200.1 - 3.8e-35 120.6 0.0 5.9e-34 116.8 0.0 2.2 1 1 1 2 2 2 1 Molybdenum Cofactor Synthesis C Radical_SAM PF04055.21 EMD66200.1 - 9.7e-27 94.4 0.0 1.9e-26 93.4 0.0 1.5 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_12 PF13353.6 EMD66200.1 - 0.00012 22.4 0.0 0.00038 20.7 0.0 1.8 2 0 0 2 2 2 1 4Fe-4S single cluster domain Enolase_N PF03952.16 EMD66200.1 - 0.2 11.9 0.0 0.37 11.0 0.0 1.4 1 0 0 1 1 1 0 Enolase, N-terminal domain His_Phos_2 PF00328.22 EMD66201.1 - 8e-62 209.8 0.0 9.7e-62 209.5 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) AA_permease_2 PF13520.6 EMD66202.1 - 9.2e-59 199.4 55.1 1.1e-58 199.1 55.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EMD66202.1 - 2.7e-16 59.3 45.6 3.7e-16 58.8 45.6 1.1 1 0 0 1 1 1 1 Amino acid permease adh_short_C2 PF13561.6 EMD66203.1 - 2.1e-39 135.5 0.2 2.7e-39 135.1 0.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EMD66203.1 - 4.2e-38 130.8 0.0 5.7e-38 130.3 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EMD66203.1 - 2.6e-10 40.5 0.2 4e-10 39.9 0.2 1.2 1 0 0 1 1 1 1 KR domain AAA PF00004.29 EMD66204.1 - 3.3e-17 63.2 0.0 5.8e-17 62.3 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EMD66204.1 - 0.0015 18.9 0.0 0.0038 17.6 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EMD66204.1 - 0.0016 18.8 0.6 0.022 15.0 0.0 2.8 2 1 1 3 3 3 1 AAA domain AAA_5 PF07728.14 EMD66204.1 - 0.034 14.1 0.0 0.073 13.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 EMD66204.1 - 0.072 12.8 0.0 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain DUF1599 PF07659.11 EMD66204.1 - 0.13 12.7 0.4 30 5.2 0.0 2.7 2 0 0 2 2 2 0 Nucleotide modification associated domain 1 Torsin PF06309.11 EMD66204.1 - 0.14 12.2 0.0 0.3 11.2 0.0 1.4 1 0 0 1 1 1 0 Torsin Zot PF05707.12 EMD66204.1 - 1.9 8.1 4.2 8.8 5.9 0.0 3.1 3 1 1 4 4 4 0 Zonular occludens toxin (Zot) DUF3427 PF11907.8 EMD66205.1 - 0.0017 17.7 0.7 0.0036 16.6 0.7 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3427) TMPIT PF07851.13 EMD66205.1 - 0.49 9.6 6.5 0.13 11.5 2.1 2.0 2 0 0 2 2 2 0 TMPIT-like protein DUF2935 PF11155.8 EMD66205.1 - 0.72 10.2 4.0 4.2 7.7 0.6 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF2935) DUF4806 PF16064.5 EMD66205.1 - 8.4 6.8 7.2 31 5.0 0.2 4.1 5 0 0 5 5 5 0 Domain of unknown function (DUF4806) AA_permease_2 PF13520.6 EMD66207.1 - 1.2e-22 80.3 43.0 4.7e-14 52.1 17.2 2.2 1 1 1 2 2 2 2 Amino acid permease AA_permease PF00324.21 EMD66207.1 - 1.4e-16 60.1 33.2 1.2e-08 34.0 17.7 2.2 1 1 1 2 2 2 2 Amino acid permease DUF1350 PF07082.11 EMD66207.1 - 0.023 14.0 0.1 0.18 11.1 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1350) Glycophorin_A PF01102.18 EMD66207.1 - 0.13 12.5 0.1 4.5 7.5 0.0 2.8 3 0 0 3 3 3 0 Glycophorin A DASH_Spc34 PF08657.10 EMD66208.1 - 6.8e-43 147.3 0.5 1.3e-20 74.3 0.2 2.2 1 1 1 2 2 2 2 DASH complex subunit Spc34 Acyl-CoA_dh_1 PF00441.24 EMD66208.1 - 7e-26 91.2 4.2 1.1e-25 90.6 0.9 2.2 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 EMD66208.1 - 1.2e-13 51.7 0.0 3.4e-13 50.3 0.0 1.8 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 EMD66208.1 - 1.2e-06 28.8 0.0 1.2e-06 28.8 0.0 2.7 3 0 0 3 3 3 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 EMD66208.1 - 6.8e-05 23.0 0.0 0.00015 21.9 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Spc7 PF08317.11 EMD66208.1 - 0.0071 15.3 3.0 0.013 14.4 3.0 1.3 1 0 0 1 1 1 1 Spc7 kinetochore protein DegS PF05384.11 EMD66208.1 - 0.24 10.9 6.3 0.41 10.1 6.3 1.3 1 0 0 1 1 1 0 Sensor protein DegS ZapB PF06005.12 EMD66208.1 - 5.6 7.5 11.7 1.6 9.3 1.6 3.0 3 0 0 3 3 3 0 Cell division protein ZapB Rpn3_C PF08375.11 EMD66209.1 - 2.8e-27 94.9 1.2 1.2e-26 92.9 1.4 1.9 2 0 0 2 2 2 1 Proteasome regulatory subunit C-terminal PCI PF01399.27 EMD66209.1 - 1e-22 80.6 1.7 5.1e-22 78.4 0.1 2.8 3 0 0 3 3 3 1 PCI domain Sigma70_r1_2 PF00140.20 EMD66209.1 - 1.6 8.8 4.7 1.6 8.8 2.0 2.3 2 0 0 2 2 2 0 Sigma-70 factor, region 1.2 Ank_2 PF12796.7 EMD66210.1 - 1.6e-27 95.9 6.0 5e-10 39.8 0.5 2.8 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMD66210.1 - 1.7e-19 69.9 0.9 6.5e-08 33.0 0.1 3.8 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EMD66210.1 - 3.8e-17 62.1 1.3 2.5e-05 24.5 0.1 4.5 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMD66210.1 - 1.3e-16 59.0 2.2 0.00093 19.5 0.0 5.9 6 0 0 6 6 6 4 Ankyrin repeat Ank PF00023.30 EMD66210.1 - 1.2e-11 44.5 4.9 0.0057 17.0 0.2 5.2 5 0 0 5 5 5 4 Ankyrin repeat LCAT PF02450.15 EMD66213.1 - 0.011 14.9 0.0 0.029 13.5 0.0 1.6 1 1 0 1 1 1 0 Lecithin:cholesterol acyltransferase Hydrolase_4 PF12146.8 EMD66213.1 - 0.066 12.5 0.0 0.14 11.4 0.0 1.5 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Palm_thioest PF02089.15 EMD66213.1 - 0.11 12.3 0.0 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 Palmitoyl protein thioesterase zf-C2H2 PF00096.26 EMD66215.1 - 1.7e-07 31.3 10.5 0.0031 17.9 1.2 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMD66215.1 - 0.005 17.6 13.9 0.13 13.2 0.4 3.4 3 0 0 3 3 3 2 C2H2-type zinc finger SAP18 PF06487.12 EMD66216.1 - 5.3e-52 175.7 0.0 6.3e-52 175.5 0.0 1.1 1 0 0 1 1 1 1 Sin3 associated polypeptide p18 (SAP18) Tubulin_3 PF14881.6 EMD66217.1 - 6.3e-78 260.6 0.0 6.3e-78 260.6 0.0 1.9 2 0 0 2 2 2 1 Tubulin domain Prp18 PF02840.15 EMD66217.1 - 9.4e-32 110.0 3.0 1.3e-31 109.6 0.0 2.4 2 0 0 2 2 2 1 Prp18 domain Misat_Tub_SegII PF10644.9 EMD66217.1 - 1.8e-22 79.8 0.3 9.3e-22 77.6 0.0 2.2 2 0 0 2 2 2 1 Misato Segment II tubulin-like domain PRP4 PF08799.11 EMD66217.1 - 6.8e-11 41.5 0.7 6.8e-11 41.5 0.7 3.4 4 0 0 4 4 4 1 pre-mRNA processing factor 4 (PRP4) like Tubulin PF00091.25 EMD66217.1 - 0.019 15.2 0.0 0.046 13.9 0.0 1.6 1 0 0 1 1 1 0 Tubulin/FtsZ family, GTPase domain CVNH PF08881.10 EMD66218.1 - 4.2e-34 117.3 0.2 7.9e-34 116.4 0.2 1.5 1 0 0 1 1 1 1 CVNH domain LysM PF01476.20 EMD66218.1 - 2.3e-14 53.2 0.0 3.5e-14 52.6 0.0 1.3 1 0 0 1 1 1 1 LysM domain Rick_17kDa_Anti PF05433.15 EMD66218.1 - 5.1e-08 32.6 23.0 5.1e-08 32.6 23.0 3.4 3 0 0 3 3 3 1 Glycine zipper 2TM domain Gly-zipper_Omp PF13488.6 EMD66218.1 - 0.0042 17.1 17.2 0.0042 17.1 17.2 3.6 4 0 0 4 4 4 1 Glycine zipper TraT PF05818.12 EMD66218.1 - 3.7 7.2 11.8 1 9.0 7.6 2.1 2 0 0 2 2 2 0 Enterobacterial TraT complement resistance protein DUF533 PF04391.12 EMD66218.1 - 9.4 5.8 8.2 37 3.8 8.2 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF533) Ferric_reduct PF01794.19 EMD66219.1 - 2.6e-23 82.5 7.1 2.6e-23 82.5 7.1 2.5 2 1 0 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 EMD66219.1 - 2.8e-14 53.5 0.0 2.7e-11 43.8 0.0 2.5 1 1 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EMD66219.1 - 4.7e-11 42.7 0.0 5.4e-08 32.9 0.0 2.7 1 1 0 1 1 1 1 FAD-binding domain NAD_binding_1 PF00175.21 EMD66219.1 - 0.11 13.1 0.0 0.24 12.1 0.0 1.6 1 0 0 1 1 1 0 Oxidoreductase NAD-binding domain DUF3810 PF12725.7 EMD66219.1 - 0.47 9.7 2.1 0.89 8.8 2.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) zf-C2H2_assoc PF16606.5 EMD66221.1 - 0.0084 16.3 0.3 0.013 15.7 0.3 1.5 1 1 0 1 1 1 1 Unstructured conserved, between two C2H2-type zinc-fingers AMP-binding PF00501.28 EMD66222.1 - 2.8e-62 210.7 2.1 7.3e-23 80.8 0.0 4.6 4 1 0 4 4 4 4 AMP-binding enzyme PYNP_C PF07831.13 EMD66222.1 - 0.17 11.5 0.1 0.42 10.3 0.1 1.6 1 0 0 1 1 1 0 Pyrimidine nucleoside phosphorylase C-terminal domain 4HBT_3 PF13622.6 EMD66223.1 - 1.8e-81 274.0 0.1 2.2e-81 273.8 0.1 1.1 1 0 0 1 1 1 1 Thioesterase-like superfamily Acyl_CoA_thio PF02551.15 EMD66223.1 - 7e-27 93.9 0.0 1.1e-13 51.2 0.0 4.1 3 1 0 3 3 3 3 Acyl-CoA thioesterase Zn_clus PF00172.18 EMD66224.1 - 2.3e-07 30.8 7.1 4.9e-07 29.8 7.1 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CoA_trans PF01144.23 EMD66225.1 - 2.7e-101 337.5 4.3 1.9e-60 203.9 0.4 2.0 2 0 0 2 2 2 2 Coenzyme A transferase Mal_decarbox_Al PF16957.5 EMD66225.1 - 0.00014 20.4 0.5 0.00021 19.8 0.0 1.5 2 0 0 2 2 2 1 Malonate decarboxylase, alpha subunit, transporter AcetylCoA_hyd_C PF13336.6 EMD66225.1 - 0.00027 20.9 0.4 0.0006 19.8 0.1 1.7 2 0 0 2 2 2 1 Acetyl-CoA hydrolase/transferase C-terminal domain MFS_1 PF07690.16 EMD66226.1 - 3.9e-33 114.9 27.7 3.9e-33 114.9 27.7 1.3 2 0 0 2 2 2 1 Major Facilitator Superfamily UNC-93 PF05978.16 EMD66226.1 - 1e-05 25.3 1.3 2.6e-05 24.0 1.3 1.7 1 0 0 1 1 1 1 Ion channel regulatory protein UNC-93 DUF2567 PF10821.8 EMD66226.1 - 0.11 12.5 3.9 0.79 9.8 0.4 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF2567) Cu-oxidase_3 PF07732.15 EMD66227.1 - 8.2e-42 142.0 2.9 1.1e-41 141.6 0.9 2.4 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 EMD66227.1 - 3.4e-40 136.9 6.9 2.6e-37 127.6 1.1 3.9 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.22 EMD66227.1 - 3.5e-31 108.5 0.1 1.5e-30 106.4 0.0 2.1 2 0 0 2 2 2 1 Multicopper oxidase DUF2407 PF10302.9 EMD66228.1 - 5.7e-05 23.6 0.0 5.7e-05 23.6 0.0 3.2 3 0 0 3 3 3 1 DUF2407 ubiquitin-like domain ubiquitin PF00240.23 EMD66228.1 - 0.0043 16.8 0.0 0.0081 15.9 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family FemAB PF02388.16 EMD66228.1 - 0.63 8.8 7.6 0.12 11.2 0.1 2.2 2 0 0 2 2 2 0 FemAB family Connexin PF00029.19 EMD66228.1 - 2.2 8.0 9.1 3.4 7.4 0.0 2.2 2 0 0 2 2 2 0 Connexin MscS_TM PF12794.7 EMD66228.1 - 2.8 6.7 8.2 23 3.7 5.9 2.2 2 0 0 2 2 2 0 Mechanosensitive ion channel inner membrane domain 1 DUF2956 PF11169.8 EMD66228.1 - 3.4 7.9 12.6 4.8 7.4 0.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2956) PBP1_TM PF14812.6 EMD66228.1 - 3.9 7.9 0.0 3.9 7.9 0.0 2.6 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal V_ATPase_I PF01496.19 EMD66228.1 - 5.6 4.8 9.7 1.5 6.7 0.1 2.1 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Eapp_C PF10238.9 EMD66228.1 - 5.7 7.0 11.4 5.5 7.1 0.0 2.6 2 0 0 2 2 2 0 E2F-associated phosphoprotein Orf78 PF06024.12 EMD66228.1 - 5.8 7.3 9.7 0.16 12.2 0.5 2.4 2 0 0 2 2 2 0 Orf78 (ac78) Presenilin PF01080.17 EMD66228.1 - 7.3 5.2 19.9 0.96 8.1 2.1 2.3 2 0 0 2 2 2 0 Presenilin PS_Dcarbxylase PF02666.15 EMD66229.1 - 3e-76 255.5 0.0 8e-76 254.0 0.0 1.7 1 1 0 1 1 1 1 Phosphatidylserine decarboxylase ANAPC4_WD40 PF12894.7 EMD66231.1 - 0.00023 21.4 0.2 0.27 11.6 0.0 3.3 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EMD66231.1 - 0.0055 17.5 3.2 13 6.8 0.0 4.7 5 0 0 5 5 5 2 WD domain, G-beta repeat Acetyltransf_1 PF00583.25 EMD66233.1 - 0.00017 21.8 0.0 0.00041 20.6 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EMD66233.1 - 0.00019 21.8 0.0 0.00039 20.8 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EMD66233.1 - 0.0011 18.9 0.0 0.0023 17.9 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Arf PF00025.21 EMD66234.1 - 2.1e-67 226.0 1.4 2.3e-67 225.8 1.4 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EMD66234.1 - 9.7e-13 48.4 0.1 1.4e-12 47.9 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EMD66234.1 - 1.4e-12 47.5 0.0 1.6e-12 47.3 0.0 1.0 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 EMD66234.1 - 2.9e-12 46.4 1.2 6.3e-07 28.9 0.1 2.1 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 EMD66234.1 - 6.8e-10 38.7 0.0 8.2e-10 38.4 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 EMD66234.1 - 6.5e-09 35.5 0.0 7.9e-09 35.2 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 EMD66234.1 - 3.7e-08 33.4 0.0 6.3e-08 32.7 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EMD66234.1 - 6e-05 22.7 0.0 0.0014 18.2 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 EMD66234.1 - 0.019 14.5 0.4 0.054 13.0 0.4 1.9 1 1 0 1 1 1 0 Ferrous iron transport protein B 6PF2K PF01591.18 EMD66234.1 - 0.047 13.0 0.3 0.23 10.7 0.1 1.9 1 1 1 2 2 2 0 6-phosphofructo-2-kinase NTPase_1 PF03266.15 EMD66234.1 - 0.14 12.0 0.1 0.21 11.5 0.1 1.4 1 1 0 1 1 1 0 NTPase DUF4045 PF13254.6 EMD66235.1 - 2.2e-125 419.6 41.7 2.2e-125 419.6 41.7 5.6 3 2 1 5 5 5 1 Domain of unknown function (DUF4045) Gelsolin PF00626.22 EMD66235.1 - 0.00017 21.4 0.0 0.21 11.5 0.0 3.0 3 0 0 3 3 3 2 Gelsolin repeat Glyco_hydro_11 PF00457.17 EMD66236.1 - 3e-55 186.6 16.9 3.4e-55 186.4 16.9 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 11 Ribosomal_L2_C PF03947.18 EMD66237.1 - 9.1e-42 142.2 3.9 1.6e-41 141.5 3.9 1.4 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 EMD66237.1 - 3e-14 52.7 0.1 7.3e-14 51.5 0.1 1.7 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain Mg_trans_NIPA PF05653.14 EMD66238.1 - 7.8e-102 340.3 14.3 1e-101 339.9 14.3 1.1 1 0 0 1 1 1 1 Magnesium transporter NIPA ANAPC4 PF12896.7 EMD66238.1 - 5e-57 192.7 2.0 7.9e-57 192.1 2.0 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 4 ANAPC4_WD40 PF12894.7 EMD66238.1 - 6.7e-23 80.8 0.0 2.4e-22 79.0 0.0 2.0 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain EamA PF00892.20 EMD66238.1 - 0.00019 21.6 6.4 0.00019 21.6 6.4 4.0 3 1 0 3 3 3 1 EamA-like transporter family DUF2420 PF10336.9 EMD66240.1 - 6.2e-17 61.6 0.1 1e-16 60.9 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2420) Adap_comp_sub PF00928.21 EMD66241.1 - 2e-17 63.4 0.0 2.7e-17 63.0 0.0 1.2 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 EMD66241.1 - 6.1e-08 32.7 0.2 9.5e-08 32.1 0.2 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain RPM2 PF08579.11 EMD66241.1 - 0.00038 20.9 1.7 0.012 16.0 1.5 2.6 2 1 0 2 2 2 1 Mitochondrial ribonuclease P subunit (RPM2) Glyco_hydro_125 PF06824.11 EMD66243.1 - 6.2e-181 601.8 0.1 7.3e-181 601.6 0.1 1.0 1 0 0 1 1 1 1 Metal-independent alpha-mannosidase (GH125) Glyco_hydro_61 PF03443.14 EMD66246.1 - 3.6e-61 206.7 1.0 4.5e-61 206.4 1.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 DWNN PF08783.11 EMD66247.1 - 4.8e-24 84.4 0.1 9.1e-24 83.5 0.1 1.5 1 0 0 1 1 1 1 DWNN domain zf-CCHC_2 PF13696.6 EMD66247.1 - 1.1e-11 44.3 5.2 2.1e-11 43.4 5.2 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-C3HC4_2 PF13923.6 EMD66247.1 - 0.00022 21.0 6.2 0.00022 21.0 6.2 1.7 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EMD66247.1 - 0.0011 19.0 4.5 0.0026 17.8 4.5 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-Nse PF11789.8 EMD66247.1 - 0.0016 18.3 1.8 0.0036 17.1 1.8 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_2 PF13639.6 EMD66247.1 - 0.0026 18.1 5.2 0.0056 17.0 5.2 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_4 PF14570.6 EMD66247.1 - 0.034 14.0 4.9 0.092 12.6 4.9 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-CCHC PF00098.23 EMD66247.1 - 0.046 13.8 0.5 0.13 12.4 0.5 1.8 1 0 0 1 1 1 0 Zinc knuckle zf-C3HC4 PF00097.25 EMD66247.1 - 0.048 13.5 5.6 0.1 12.5 5.6 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EMD66247.1 - 0.053 13.7 7.0 0.12 12.6 7.0 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING DUF1272 PF06906.11 EMD66247.1 - 0.1 12.7 3.6 0.26 11.4 3.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) HypA PF01155.19 EMD66247.1 - 0.45 10.6 1.8 6.4 6.8 1.2 2.3 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Hid1 PF12722.7 EMD66247.1 - 2 6.4 7.2 2.9 5.9 7.2 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein GREB1 PF15782.5 EMD66247.1 - 3.2 4.8 6.6 4.3 4.3 6.6 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer FSA_C PF10479.9 EMD66247.1 - 3.6 5.6 9.1 5.3 5.0 9.1 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus zf-C3HC4_3 PF13920.6 EMD66247.1 - 7.7 6.5 10.3 0.27 11.1 4.2 1.7 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Dicty_REP PF05086.12 EMD66247.1 - 8.2 4.3 6.0 0.42 8.5 0.9 1.3 2 0 0 2 2 2 0 Dictyostelium (Slime Mold) REP protein Acetyltransf_1 PF00583.25 EMD66248.1 - 6.6e-11 42.5 0.0 1.7e-10 41.1 0.0 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EMD66248.1 - 1.3e-08 35.2 0.1 4.5e-07 30.2 0.0 2.2 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EMD66248.1 - 1.9e-07 31.1 0.1 4.5e-07 29.8 0.0 1.6 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EMD66248.1 - 1e-06 28.6 0.0 1.7e-06 27.9 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_3 PF13302.7 EMD66248.1 - 0.0029 18.3 0.0 0.005 17.5 0.0 1.8 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EMD66248.1 - 0.0073 16.4 0.0 0.023 14.8 0.0 1.8 1 1 1 2 2 2 1 GCN5-related N-acetyl-transferase KAR9 PF08580.10 EMD66251.1 - 4.3e-136 455.2 8.3 4.3e-136 455.2 8.3 2.9 2 1 0 3 3 3 1 Yeast cortical protein KAR9 eIF3_N PF09440.10 EMD66251.1 - 0.54 10.7 2.6 2.9 8.3 0.3 2.6 1 1 0 2 2 2 0 eIF3 subunit 6 N terminal domain Snf7 PF03357.21 EMD66251.1 - 0.83 9.2 8.2 0.22 11.1 0.5 3.3 3 1 1 4 4 4 0 Snf7 CH PF00307.31 EMD66252.1 - 0.025 14.7 0.0 0.087 13.0 0.0 1.8 2 0 0 2 2 2 0 Calponin homology (CH) domain YopE_N PF09020.10 EMD66252.1 - 0.13 12.5 0.4 0.31 11.3 0.4 1.6 1 0 0 1 1 1 0 YopE, N terminal Acylphosphatase PF00708.18 EMD66253.1 - 3.3e-27 94.7 0.2 3.7e-27 94.6 0.2 1.0 1 0 0 1 1 1 1 Acylphosphatase PTA_PTB PF01515.19 EMD66253.1 - 0.12 11.7 0.0 0.12 11.7 0.0 1.1 1 0 0 1 1 1 0 Phosphate acetyl/butaryl transferase AMP-binding PF00501.28 EMD66254.1 - 3.3e-67 226.9 0.0 3.2e-66 223.7 0.0 2.0 1 1 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EMD66254.1 - 9.8e-12 45.7 0.1 2.1e-11 44.6 0.1 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Aminotran_3 PF00202.21 EMD66255.1 - 2.5e-88 296.5 0.0 3.1e-88 296.2 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_3 PF00202.21 EMD66256.1 - 2.6e-44 151.5 0.0 4.7e-43 147.4 0.0 2.0 1 1 0 1 1 1 1 Aminotransferase class-III Aminotran_5 PF00266.19 EMD66256.1 - 0.033 13.1 0.0 0.049 12.6 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class-V Fungal_trans PF04082.18 EMD66257.1 - 2.4e-15 56.3 0.1 4.4e-15 55.4 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD66257.1 - 0.00021 21.3 9.7 0.00042 20.4 9.7 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain COX17 PF05051.13 EMD66257.1 - 0.05 14.0 0.4 0.14 12.6 0.4 1.7 1 0 0 1 1 1 0 Cytochrome C oxidase copper chaperone (COX17) AOX PF01786.17 EMD66258.1 - 3.4e-97 324.2 0.4 4.2e-97 323.9 0.4 1.1 1 0 0 1 1 1 1 Alternative oxidase COQ7 PF03232.13 EMD66258.1 - 0.12 12.2 0.3 0.74 9.6 0.0 2.3 2 1 0 2 2 2 0 Ubiquinone biosynthesis protein COQ7 GMC_oxred_N PF00732.19 EMD66259.1 - 7.2e-80 268.5 0.0 1e-79 268.0 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EMD66259.1 - 1.9e-33 116.0 0.0 4.1e-33 114.9 0.0 1.6 1 0 0 1 1 1 1 GMC oxidoreductase DAO PF01266.24 EMD66259.1 - 0.00016 21.4 1.0 0.00048 19.8 1.0 1.8 1 1 0 1 1 1 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 EMD66259.1 - 0.00018 20.7 0.1 0.00031 19.9 0.1 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_2 PF07992.14 EMD66259.1 - 0.0047 16.2 0.0 0.0091 15.3 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EMD66259.1 - 0.0067 15.5 0.2 1.3 8.0 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain Thi4 PF01946.17 EMD66259.1 - 0.007 15.6 0.5 0.071 12.3 0.1 2.1 2 0 0 2 2 2 1 Thi4 family Pyr_redox PF00070.27 EMD66259.1 - 0.063 13.8 0.4 0.57 10.8 0.1 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EMD66260.1 - 1.7e-11 43.9 0.0 1.6e-07 30.9 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EMD66260.1 - 0.003 17.2 0.2 0.0052 16.4 0.2 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EMD66260.1 - 0.087 12.8 0.0 0.19 11.7 0.0 1.6 1 0 0 1 1 1 0 FAD-NAD(P)-binding Pyr_redox_3 PF13738.6 EMD66260.1 - 0.16 11.2 0.0 4.8 6.3 0.0 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Fungal_trans PF04082.18 EMD66261.1 - 1.8e-14 53.5 0.2 3.1e-14 52.6 0.2 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD66261.1 - 2.8e-07 30.5 8.2 5.6e-07 29.6 8.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SH3_9 PF14604.6 EMD66262.1 - 2.2e-09 37.0 0.0 3.4e-09 36.4 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EMD66262.1 - 1.3e-06 27.9 0.0 1.9e-06 27.3 0.0 1.3 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 EMD66262.1 - 2.7e-06 27.0 0.0 4e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain Podoplanin PF05808.11 EMD66262.1 - 2.6e-05 24.4 0.0 5e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Podoplanin Syndecan PF01034.20 EMD66262.1 - 0.15 12.0 1.1 0.29 11.1 1.1 1.4 1 0 0 1 1 1 0 Syndecan domain Chordopox_A13L PF05961.11 EMD66262.1 - 0.22 11.8 0.0 0.55 10.5 0.0 1.6 1 0 0 1 1 1 0 Chordopoxvirus A13L protein TPPK_C PF12555.8 EMD66262.1 - 1.6 8.8 6.9 0.72 10.0 1.6 2.7 2 0 0 2 2 2 0 Thiamine pyrophosphokinase C terminal CorA PF01544.18 EMD66263.1 - 1.4e-07 31.1 6.0 2.2e-07 30.5 6.0 1.4 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein RasGEF PF00617.19 EMD66264.1 - 5.5e-46 157.0 0.2 8.7e-46 156.3 0.2 1.3 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 EMD66264.1 - 3.1e-11 43.4 0.3 7.7e-11 42.2 0.3 1.7 1 0 0 1 1 1 1 RasGEF N-terminal motif DUF3445 PF11927.8 EMD66265.1 - 3.9e-79 265.4 0.0 5e-79 265.1 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3445) Glyco_transf_22 PF03901.17 EMD66266.1 - 7.2e-82 275.8 22.1 8.4e-82 275.6 22.1 1.0 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family PMT PF02366.18 EMD66266.1 - 2.7e-05 23.9 7.2 2.7e-05 23.9 7.2 2.1 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase Gar1 PF04410.14 EMD66267.1 - 1.1e-40 139.0 4.8 1.1e-40 139.0 4.8 2.6 2 0 0 2 2 2 1 Gar1/Naf1 RNA binding region PP2C PF00481.21 EMD66268.1 - 4.3e-51 174.0 0.0 7.2e-51 173.3 0.0 1.4 1 0 0 1 1 1 1 Protein phosphatase 2C LRR_8 PF13855.6 EMD66268.1 - 4.3e-40 135.3 48.8 2.3e-09 36.9 0.3 9.8 5 3 4 10 10 10 8 Leucine rich repeat LRR_4 PF12799.7 EMD66268.1 - 5.4e-35 118.8 55.3 5.9e-05 23.3 0.8 13.1 8 4 3 13 13 13 11 Leucine Rich repeats (2 copies) Guanylate_cyc PF00211.20 EMD66268.1 - 1.8e-32 112.4 0.0 1.8e-30 105.9 0.0 2.3 1 1 1 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain Ad_cyc_g-alpha PF08509.11 EMD66268.1 - 2.8e-06 26.9 0.3 8.6e-06 25.4 0.3 1.8 1 0 0 1 1 1 1 Adenylate cyclase G-alpha binding domain RA PF00788.23 EMD66268.1 - 4e-06 27.4 0.2 5.5e-05 23.7 0.1 2.5 2 0 0 2 2 2 1 Ras association (RalGDS/AF-6) domain LRR_9 PF14580.6 EMD66268.1 - 1.6e-05 24.5 12.5 1.4 8.4 0.3 4.6 2 1 3 5 5 5 5 Leucine-rich repeat LRR_5 PF13306.6 EMD66268.1 - 0.00032 20.7 0.0 2.5 8.0 0.0 3.6 3 0 0 3 3 3 1 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 EMD66268.1 - 0.00043 20.4 53.1 2.2 9.2 0.0 16.1 15 4 1 16 16 16 1 Leucine Rich Repeat Indigoidine_A PF04227.12 EMD66269.1 - 2.5e-123 411.1 0.3 3.7e-123 410.5 0.3 1.3 1 0 0 1 1 1 1 Indigoidine synthase A like protein PfkB PF00294.24 EMD66269.1 - 5.7e-25 88.2 0.4 2.5e-13 50.0 0.0 2.9 3 0 0 3 3 3 2 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.12 EMD66269.1 - 0.00014 21.3 0.1 0.043 13.2 0.0 2.3 2 0 0 2 2 2 2 Phosphomethylpyrimidine kinase Pox_F17 PF04767.12 EMD66269.1 - 0.19 12.3 0.3 0.41 11.2 0.3 1.5 1 0 0 1 1 1 0 DNA-binding 11 kDa phosphoprotein Ribophorin_I PF04597.14 EMD66270.1 - 2.7e-155 517.9 0.3 3.1e-155 517.7 0.3 1.0 1 0 0 1 1 1 1 Ribophorin I ATP_bind_2 PF03668.15 EMD66271.1 - 0.0011 18.3 0.0 0.0012 18.2 0.0 1.1 1 0 0 1 1 1 1 P-loop ATPase protein family Peptidase_M36 PF02128.15 EMD66272.1 - 0.24 10.5 0.1 0.28 10.3 0.1 1.1 1 0 0 1 1 1 0 Fungalysin metallopeptidase (M36) Zn_clus PF00172.18 EMD66273.1 - 5.5e-09 36.0 13.1 1e-08 35.2 13.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain p450 PF00067.22 EMD66276.1 - 2.7e-48 164.9 0.0 3.5e-47 161.2 0.0 2.1 1 1 0 1 1 1 1 Cytochrome P450 GP52 PF17468.2 EMD66276.1 - 0.034 14.3 0.0 0.091 12.9 0.0 1.7 1 0 0 1 1 1 0 Phage gene product 52 TAtT PF16811.5 EMD66276.1 - 0.18 11.1 0.3 0.31 10.3 0.3 1.3 1 0 0 1 1 1 0 TRAP transporter T-component CinA PF02464.17 EMD66277.1 - 3.5e-36 124.1 3.2 4.2e-36 123.8 3.2 1.0 1 0 0 1 1 1 1 Competence-damaged protein DnaJ_C PF01556.18 EMD66279.1 - 7.3e-27 94.3 0.0 1.1e-26 93.7 0.0 1.3 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EMD66279.1 - 5.5e-26 90.5 3.8 9.7e-26 89.7 3.8 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 EMD66279.1 - 6.7e-15 55.2 16.1 1.1e-14 54.5 16.1 1.3 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 EMD66279.1 - 1.7e-05 24.7 8.4 0.0035 17.3 0.4 2.3 2 0 0 2 2 2 2 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.19 EMD66279.1 - 0.0022 18.0 8.4 0.24 11.5 0.9 2.3 2 0 0 2 2 2 2 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Lar_restr_allev PF14354.6 EMD66279.1 - 0.014 15.8 8.6 0.37 11.2 1.3 2.9 1 1 2 3 3 3 0 Restriction alleviation protein Lar TackOD1 PF18551.1 EMD66279.1 - 2.2 7.9 8.9 0.58 9.8 1.6 2.2 1 1 1 2 2 2 0 Thaumarchaeal output domain 1 Ribosomal_S17 PF00366.20 EMD66280.1 - 1.2e-18 66.9 3.0 3.2e-18 65.6 1.4 2.3 2 0 0 2 2 2 1 Ribosomal protein S17 Cnd1_N PF12922.7 EMD66281.1 - 2.9e-60 202.9 0.2 1e-59 201.1 0.0 2.1 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1, N-term Cnd1 PF12717.7 EMD66281.1 - 1.1e-47 162.1 9.6 1.3e-43 148.9 0.1 4.5 4 1 0 5 5 5 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EMD66281.1 - 6.7e-08 32.8 6.3 0.026 14.9 0.0 6.3 6 1 1 7 7 7 3 HEAT repeats HEAT PF02985.22 EMD66281.1 - 5.4e-07 29.3 9.8 0.35 11.2 0.1 7.7 7 1 1 8 8 8 2 HEAT repeat RTP1_C1 PF10363.9 EMD66281.1 - 1e-05 25.7 1.7 0.24 11.6 0.0 4.3 3 1 0 3 3 3 2 Required for nuclear transport of RNA pol II C-terminus 1 Cnd3 PF12719.7 EMD66281.1 - 0.00058 19.1 5.1 0.0031 16.8 1.1 3.1 2 1 0 2 2 2 1 Nuclear condensing complex subunits, C-term domain HEAT_EZ PF13513.6 EMD66281.1 - 0.013 15.9 5.7 42 4.8 0.0 5.8 6 0 0 6 6 6 0 HEAT-like repeat YtzH PF14165.6 EMD66281.1 - 0.14 12.5 0.2 0.93 9.9 0.0 2.4 2 0 0 2 2 2 0 YtzH-like protein p450 PF00067.22 EMD66281.1 - 0.16 10.7 2.8 0.18 10.5 0.2 2.2 2 1 1 3 3 3 0 Cytochrome P450 TIP120 PF08623.10 EMD66281.1 - 0.91 9.3 4.5 2.6 7.8 0.8 3.6 4 1 0 4 4 4 0 TATA-binding protein interacting (TIP20) Pkinase PF00069.25 EMD66282.1 - 9.4e-43 146.5 0.0 2.4e-39 135.3 0.0 3.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD66282.1 - 9.5e-12 44.7 0.0 1.3e-07 31.2 0.0 2.9 2 1 0 2 2 2 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 EMD66282.1 - 0.00022 20.1 0.2 0.0035 16.2 0.0 2.1 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 EMD66282.1 - 0.00051 19.4 0.0 0.21 10.9 0.0 2.3 2 0 0 2 2 2 2 Kinase-like APH PF01636.23 EMD66282.1 - 0.0021 18.0 0.8 0.047 13.6 0.0 3.0 3 1 1 4 4 4 1 Phosphotransferase enzyme family FTA2 PF13095.6 EMD66282.1 - 0.054 13.1 0.2 0.36 10.4 0.0 2.3 2 1 1 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 Pro-kuma_activ PF09286.11 EMD66283.1 - 8.3e-41 139.6 0.0 1.5e-40 138.8 0.0 1.4 1 0 0 1 1 1 1 Pro-kumamolisin, activation domain RNA_pol_Rpb2_6 PF00562.28 EMD66284.1 - 8.2e-113 377.4 0.2 1.1e-112 376.9 0.2 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 EMD66284.1 - 3.6e-37 127.8 0.0 5.7e-37 127.2 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_3 PF04565.16 EMD66284.1 - 5e-27 93.9 0.0 1.7e-26 92.1 0.0 2.0 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpa2_4 PF06883.12 EMD66284.1 - 6.6e-25 86.9 0.0 1.5e-24 85.8 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase I, Rpa2 specific domain RNA_pol_Rpb2_2 PF04561.14 EMD66284.1 - 2.4e-22 79.5 0.0 4.5e-22 78.6 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.20 EMD66284.1 - 6.2e-15 55.4 0.0 7.2e-14 52.0 0.0 2.4 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 7 Rpr2 PF04032.16 EMD66284.1 - 0.039 14.2 0.6 0.08 13.2 0.6 1.5 1 0 0 1 1 1 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain Arf PF00025.21 EMD66285.1 - 1.9e-44 151.2 0.0 2.3e-44 150.9 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 EMD66285.1 - 3.8e-18 65.6 0.0 4.4e-18 65.4 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMD66285.1 - 1.1e-15 57.9 0.0 1.7e-15 57.3 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EMD66285.1 - 3.1e-08 33.3 0.0 3.6e-08 33.0 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 EMD66285.1 - 1e-06 28.8 0.0 1.5e-06 28.3 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EMD66285.1 - 9.3e-06 25.2 0.0 1.1e-05 24.9 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.20 EMD66285.1 - 0.00019 20.7 0.2 0.0011 18.2 0.1 2.0 1 1 1 2 2 2 1 G-protein alpha subunit FeoB_N PF02421.18 EMD66285.1 - 0.0086 15.6 0.2 0.017 14.7 0.2 1.8 1 1 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EMD66285.1 - 0.054 13.6 0.0 0.31 11.1 0.1 1.9 1 1 1 2 2 2 0 Dynamin family MMR_HSR1_Xtn PF16897.5 EMD66285.1 - 0.15 12.1 0.0 0.24 11.4 0.0 1.4 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain RCR PF12273.8 EMD66287.1 - 1.1e-21 77.7 7.0 1.4e-21 77.4 7.0 1.1 1 0 0 1 1 1 1 Chitin synthesis regulation, resistance to Congo red SARAF PF06682.12 EMD66287.1 - 1.2e-05 25.2 0.1 1.3e-05 25.0 0.1 1.1 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis Shisa PF13908.6 EMD66287.1 - 0.0045 17.2 0.0 0.0061 16.8 0.0 1.2 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator DUF2207 PF09972.9 EMD66287.1 - 0.018 13.9 0.0 0.019 13.7 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) OSTbeta PF15048.6 EMD66287.1 - 0.021 14.9 0.0 0.028 14.6 0.0 1.2 1 0 0 1 1 1 0 Organic solute transporter subunit beta protein TMEM119 PF15724.5 EMD66287.1 - 0.026 14.6 0.0 0.038 14.1 0.0 1.2 1 0 0 1 1 1 0 TMEM119 family LYRIC PF15686.5 EMD66287.1 - 0.064 12.8 0.0 0.082 12.5 0.0 1.1 1 0 0 1 1 1 0 Lysine-rich CEACAM1 co-isolated protein family TMEM52 PF14979.6 EMD66287.1 - 0.068 13.1 1.4 0.07 13.0 0.1 1.6 2 0 0 2 2 2 0 Transmembrane 52 Comm PF15957.5 EMD66287.1 - 0.081 13.3 0.0 0.11 12.9 0.0 1.3 1 0 0 1 1 1 0 Commissureless TMEM51 PF15345.6 EMD66287.1 - 0.16 11.8 0.0 0.19 11.6 0.0 1.1 1 0 0 1 1 1 0 Transmembrane protein 51 WBP-1 PF11669.8 EMD66287.1 - 0.56 10.9 3.4 1.6 9.4 3.4 1.7 1 1 0 1 1 1 0 WW domain-binding protein 1 Synaptobrevin PF00957.21 EMD66287.1 - 0.77 9.6 2.1 1.1 9.0 2.1 1.2 1 0 0 1 1 1 0 Synaptobrevin Coatomer_WDAD PF04053.14 EMD66288.1 - 4.8e-145 484.0 0.1 7.8e-145 483.3 0.1 1.3 1 0 0 1 1 1 1 Coatomer WD associated region COPI_C PF06957.11 EMD66288.1 - 2.4e-93 313.1 0.0 3.4e-93 312.6 0.0 1.1 1 0 0 1 1 1 1 Coatomer (COPI) alpha subunit C-terminus WD40 PF00400.32 EMD66288.1 - 9.4e-35 118.1 18.1 2e-07 31.6 0.3 7.4 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD66288.1 - 2.6e-06 27.7 0.2 0.08 13.2 0.0 5.1 4 1 2 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EMD66288.1 - 0.039 12.6 5.9 3.7 6.1 0.1 3.6 2 1 1 4 4 4 0 Nucleoporin Nup120/160 Clathrin PF00637.20 EMD66288.1 - 0.32 10.9 3.0 0.4 10.5 0.1 2.6 3 0 0 3 3 3 0 Region in Clathrin and VPS Cupin_1 PF00190.22 EMD66290.1 - 8.5e-17 61.2 0.7 8.5e-17 61.2 0.7 1.6 2 0 0 2 2 2 1 Cupin RAMA PF18755.1 EMD66290.1 - 0.014 15.8 0.0 0.025 15.0 0.0 1.4 1 0 0 1 1 1 0 Restriction Enzyme Adenine Methylase Associated Cupin_2 PF07883.11 EMD66290.1 - 0.16 11.7 0.1 0.4 10.4 0.1 1.8 1 1 0 1 1 1 0 Cupin domain tRNA-synt_1b PF00579.25 EMD66291.1 - 1.1e-62 212.0 0.0 1.7e-62 211.4 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) MscS_porin PF12795.7 EMD66291.1 - 0.013 15.1 0.4 0.026 14.1 0.4 1.4 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain Sugarporin_N PF11471.8 EMD66291.1 - 0.08 12.9 1.8 0.17 11.8 1.8 1.6 1 0 0 1 1 1 0 Maltoporin periplasmic N-terminal extension RAP1 PF07218.11 EMD66291.1 - 0.19 10.0 0.7 0.27 9.5 0.1 1.4 2 0 0 2 2 2 0 Rhoptry-associated protein 1 (RAP-1) SNARE PF05739.19 EMD66291.1 - 0.21 11.6 0.4 0.47 10.5 0.4 1.5 1 0 0 1 1 1 0 SNARE domain ATP-synt_B PF00430.18 EMD66291.1 - 2.4 8.3 7.1 0.46 10.6 3.2 1.8 2 0 0 2 2 2 0 ATP synthase B/B' CF(0) LCAT PF02450.15 EMD66292.1 - 1.2e-105 354.0 0.0 1.4e-105 353.7 0.0 1.1 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase DUF1749 PF08538.10 EMD66292.1 - 0.0062 15.7 0.0 0.01 14.9 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1749) Tobravirus_2B PF05271.11 EMD66292.1 - 0.066 13.1 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 Tobravirus 2B protein Acetyltransf_1 PF00583.25 EMD66293.1 - 4e-19 69.0 0.0 5.9e-19 68.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EMD66293.1 - 8.4e-11 42.2 0.0 1.2e-10 41.6 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EMD66293.1 - 1.3e-10 41.1 0.0 2e-10 40.5 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.7 EMD66293.1 - 5e-10 39.4 0.0 7.3e-10 38.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 EMD66293.1 - 3.1e-09 37.6 0.0 3.8e-09 37.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 EMD66293.1 - 6e-07 29.3 0.0 9e-07 28.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EMD66293.1 - 1.1e-05 25.5 0.0 1.9e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EMD66293.1 - 0.00091 19.3 0.0 0.0016 18.6 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase GNAT_acetyltran PF12746.7 EMD66293.1 - 0.0029 17.2 0.0 0.0045 16.6 0.0 1.3 1 0 0 1 1 1 1 GNAT acetyltransferase PaaA_PaaC PF05138.12 EMD66294.1 - 0.1 11.7 0.0 0.17 11.0 0.0 1.2 1 0 0 1 1 1 0 Phenylacetic acid catabolic protein HALZ PF02183.18 EMD66294.1 - 0.53 10.6 4.3 0.55 10.5 0.4 2.8 3 0 0 3 3 3 0 Homeobox associated leucine zipper Peptidase_S15 PF02129.18 EMD66295.1 - 0.0005 19.7 0.0 0.00052 19.7 0.0 1.2 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) PhyH PF05721.13 EMD66296.1 - 7.9e-07 29.5 0.0 2e-06 28.2 0.0 1.6 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) DUF1479 PF07350.12 EMD66296.1 - 2.7e-05 23.1 0.6 0.16 10.7 0.1 2.8 3 0 0 3 3 3 2 Protein of unknown function (DUF1479) 2OG-FeII_Oxy_5 PF13759.6 EMD66296.1 - 0.056 13.9 0.0 0.12 12.8 0.0 1.6 1 0 0 1 1 1 0 Putative 2OG-Fe(II) oxygenase 2OG-FeII_Oxy_3 PF13640.6 EMD66296.1 - 0.12 13.2 0.0 0.28 12.1 0.0 1.6 1 1 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily Fungal_trans PF04082.18 EMD66297.1 - 3.7e-09 36.0 0.1 8e-09 34.9 0.1 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD66297.1 - 1.5e-05 25.0 13.9 3.1e-05 24.0 13.9 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Cep3 PF16846.5 EMD66297.1 - 0.013 14.0 0.0 0.019 13.4 0.0 1.1 1 0 0 1 1 1 0 Centromere DNA-binding protein complex CBF3 subunit B RILP PF11461.8 EMD66297.1 - 0.16 12.2 0.0 0.32 11.2 0.0 1.4 1 0 0 1 1 1 0 Rab interacting lysosomal protein MFS_1 PF07690.16 EMD66298.1 - 2.3e-22 79.4 26.7 2.3e-22 79.4 26.7 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily DUF1772 PF08592.11 EMD66298.1 - 0.012 15.9 0.1 0.012 15.9 0.1 3.5 2 2 2 4 4 4 0 Domain of unknown function (DUF1772) TFIID_20kDa PF03847.13 EMD66299.1 - 2.3e-22 79.3 0.2 4.3e-22 78.4 0.2 1.5 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A Exo_endo_phos PF03372.23 EMD66299.1 - 1e-13 51.4 0.0 4.9e-13 49.2 0.0 2.0 2 0 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family Luciferase_cat PF10285.9 EMD66299.1 - 0.0087 15.5 0.0 0.015 14.7 0.0 1.3 1 0 0 1 1 1 1 Luciferase catalytic domain DUF2390 PF09523.10 EMD66299.1 - 0.29 11.5 9.4 0.11 12.8 1.5 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2390) WD40 PF00400.32 EMD66300.1 - 2.9e-60 198.8 20.2 2.4e-13 50.3 0.2 7.5 7 1 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD66300.1 - 8.8e-22 77.2 0.4 0.00027 21.2 0.0 6.2 2 1 3 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EMD66300.1 - 1.6e-10 40.5 0.1 0.0063 15.5 0.0 4.2 2 1 2 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 EMD66300.1 - 1.8e-07 31.2 0.0 0.00038 20.4 0.0 3.4 2 1 2 4 4 4 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 EMD66300.1 - 5.3e-06 26.0 0.0 0.00012 21.5 0.0 2.2 2 0 0 2 2 2 1 WD40-like domain PD40 PF07676.12 EMD66300.1 - 9.6e-05 22.2 0.0 0.78 9.8 0.0 4.2 3 0 0 3 3 3 1 WD40-like Beta Propeller Repeat Frtz PF11768.8 EMD66300.1 - 0.0001 20.8 0.0 0.0015 17.0 0.0 2.4 2 1 1 3 3 3 1 WD repeat-containing and planar cell polarity effector protein Fritz Nup160 PF11715.8 EMD66300.1 - 0.0001 21.1 5.4 0.016 13.9 0.6 4.8 2 2 2 4 4 4 1 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 EMD66300.1 - 0.0055 15.5 0.3 0.52 9.0 0.0 3.4 3 1 1 4 4 4 1 Nup133 N terminal like DUF1513 PF07433.11 EMD66300.1 - 0.012 14.7 0.3 3.3 6.7 0.0 3.3 1 1 3 4 4 4 0 Protein of unknown function (DUF1513) VID27 PF08553.10 EMD66300.1 - 0.023 13.8 0.0 1.1 8.2 0.0 3.0 2 1 1 3 3 3 0 VID27 C-terminal WD40-like domain RrnaAD PF00398.20 EMD66301.1 - 1.1e-63 214.8 0.0 1.5e-63 214.4 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_25 PF13649.6 EMD66301.1 - 7.7e-07 29.7 0.0 1.5e-06 28.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMD66301.1 - 8.8e-06 26.3 0.0 2.1e-05 25.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 EMD66301.1 - 2.9e-05 23.9 0.0 4.8e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.14 EMD66301.1 - 0.00038 20.1 0.0 0.00062 19.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_23 PF13489.6 EMD66301.1 - 0.00047 20.0 0.0 0.00086 19.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMD66301.1 - 0.0044 17.7 0.0 0.012 16.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMD66301.1 - 0.0048 16.7 0.0 0.008 16.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.18 EMD66301.1 - 0.023 14.0 0.0 0.04 13.2 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase domain Methyltransf_28 PF02636.17 EMD66301.1 - 0.043 13.4 0.0 0.087 12.4 0.0 1.5 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase CMAS PF02353.20 EMD66301.1 - 0.1 11.9 0.0 0.17 11.2 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase DREV PF05219.12 EMD66301.1 - 0.15 11.2 0.0 0.23 10.5 0.0 1.2 1 0 0 1 1 1 0 DREV methyltransferase Ada3 PF10198.9 EMD66301.1 - 0.15 12.2 0.2 0.15 12.2 0.2 1.8 2 0 0 2 2 1 0 Histone acetyltransferases subunit 3 AP_endonuc_2 PF01261.24 EMD66303.1 - 3.5e-34 118.1 0.2 5.7e-34 117.4 0.2 1.3 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel HpaB_N PF11794.8 EMD66303.1 - 0.017 14.8 0.3 0.04 13.6 0.0 1.7 2 0 0 2 2 2 0 4-hydroxyphenylacetate 3-hydroxylase N terminal Ndc1_Nup PF09531.10 EMD66303.1 - 3.5 6.2 4.1 5.9 5.5 4.1 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Zn_clus PF00172.18 EMD66304.1 - 2.8e-08 33.8 9.4 6.7e-08 32.5 9.4 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EMD66304.1 - 0.15 10.9 0.0 0.29 9.9 0.0 1.4 1 0 0 1 1 1 0 Fungal specific transcription factor domain Cupin_1 PF00190.22 EMD66305.1 - 1e-17 64.1 0.0 1.7e-17 63.5 0.0 1.2 1 0 0 1 1 1 1 Cupin Cupin_2 PF07883.11 EMD66305.1 - 0.027 14.2 0.0 0.039 13.7 0.0 1.3 1 0 0 1 1 1 0 Cupin domain RGCC PF15151.6 EMD66306.1 - 2.4 8.4 5.1 0.25 11.6 0.4 1.7 2 0 0 2 2 2 0 Response gene to complement 32 protein family Nitrate_red_gam PF02665.14 EMD66307.1 - 0.14 11.7 0.0 0.24 10.9 0.0 1.4 1 0 0 1 1 1 0 Nitrate reductase gamma subunit Gram_pos_anchor PF00746.21 EMD66307.1 - 9.2 6.3 6.2 2.9 7.9 2.6 2.1 2 0 0 2 2 2 0 LPXTG cell wall anchor motif Proteasome PF00227.26 EMD66309.1 - 2.2e-47 161.0 0.2 2.6e-47 160.8 0.2 1.1 1 0 0 1 1 1 1 Proteasome subunit JmjC PF02373.22 EMD66310.1 - 1.3e-08 35.2 0.0 2e-07 31.4 0.0 2.4 1 1 0 1 1 1 1 JmjC domain, hydroxylase PHD PF00628.29 EMD66310.1 - 3.6e-08 33.2 6.6 3.6e-08 33.2 6.6 2.3 2 0 0 2 2 2 1 PHD-finger Cupin_8 PF13621.6 EMD66310.1 - 1.7e-07 31.3 0.0 6.5e-07 29.3 0.0 2.0 1 1 0 1 1 1 1 Cupin-like domain JHD PF17811.1 EMD66310.1 - 1e-05 26.0 1.4 2.6e-05 24.7 0.8 1.9 2 0 0 2 2 2 1 Jumonji helical domain zf-PHD-like PF15446.6 EMD66310.1 - 1.8 8.1 7.5 0.29 10.8 2.3 2.2 2 0 0 2 2 2 0 PHD/FYVE-zinc-finger like domain RRM_1 PF00076.22 EMD66311.1 - 9.2e-15 54.2 0.2 2.9e-14 52.6 0.1 1.8 1 1 1 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EMD66311.1 - 0.00055 19.5 0.0 0.00062 19.4 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DPCD PF14913.6 EMD66311.1 - 0.12 11.8 0.1 0.15 11.4 0.1 1.2 1 0 0 1 1 1 0 DPCD protein family DUF1772 PF08592.11 EMD66312.1 - 0.00011 22.5 1.4 0.00017 21.9 1.4 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF1772) Tom7 PF08038.12 EMD66312.1 - 0.062 13.0 0.2 0.13 12.0 0.2 1.5 1 0 0 1 1 1 0 TOM7 family DRIM PF07539.12 EMD66313.1 - 2.4e-184 614.1 3.5 2.4e-184 614.1 3.5 3.6 4 0 0 4 4 4 2 Down-regulated in metastasis HEAT_2 PF13646.6 EMD66313.1 - 0.12 12.8 0.7 12 6.4 0.1 4.4 5 0 0 5 5 5 0 HEAT repeats DUF3384 PF11864.8 EMD66313.1 - 1.3 7.8 6.8 2.2 7.1 0.2 4.4 6 1 1 7 7 7 0 Domain of unknown function (DUF3384) CwfJ_C_1 PF04677.15 EMD66314.1 - 1e-21 77.1 0.0 2.3e-21 75.9 0.0 1.6 2 0 0 2 2 2 1 Protein similar to CwfJ C-terminus 1 CwfJ_C_2 PF04676.14 EMD66314.1 - 9.3e-16 58.5 3.5 2e-15 57.5 3.5 1.5 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 2 HIT PF01230.23 EMD66314.1 - 0.098 13.4 0.0 0.24 12.2 0.0 1.6 1 0 0 1 1 1 0 HIT domain MFS_1 PF07690.16 EMD66315.1 - 7.4e-32 110.6 28.2 1.1e-31 110.0 28.2 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_1_like PF12832.7 EMD66315.1 - 0.21 10.4 11.4 0.33 9.7 11.4 1.3 1 0 0 1 1 1 0 MFS_1 like family Gti1_Pac2 PF09729.9 EMD66316.1 - 1e-45 156.1 0.9 5.3e-38 130.9 0.1 2.4 1 1 1 2 2 2 2 Gti1/Pac2 family p450 PF00067.22 EMD66317.1 - 6.8e-75 252.6 0.0 9.7e-75 252.1 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 TetR_C_26 PF17934.1 EMD66317.1 - 0.047 14.0 0.0 0.14 12.5 0.0 1.8 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain 7TMR-HDED PF07697.11 EMD66317.1 - 0.1 12.7 0.0 3.2 7.8 0.3 2.4 2 1 0 2 2 2 0 7TM-HD extracellular Fungal_trans_2 PF11951.8 EMD66319.1 - 8e-11 41.4 0.0 9.3e-08 31.3 0.0 2.2 2 1 0 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD66319.1 - 5.9e-06 26.3 9.9 1.1e-05 25.4 9.9 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Gal_GalNac_35kD PF17337.2 EMD66319.1 - 0.12 12.4 0.0 0.2 11.7 0.0 1.3 1 0 0 1 1 1 0 Galactose-inhibitable lectin 35 kDa subunit TRP PF06011.12 EMD66320.1 - 3.1e-140 467.7 13.3 3.9e-140 467.4 13.3 1.0 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.6 EMD66320.1 - 3.4e-39 134.4 1.3 4.1e-39 134.1 0.5 1.6 2 0 0 2 2 2 1 ML-like domain DUF3915 PF13054.6 EMD66322.1 - 4.4 7.3 5.0 7.2 6.6 5.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Glyco_hydro_cc PF11790.8 EMD66323.1 - 9.7e-73 244.7 1.8 1.2e-72 244.4 1.8 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core Glyco_hydro81C PF17652.1 EMD66324.1 - 1.8e-160 534.0 6.3 1.8e-160 534.0 6.3 1.4 2 0 0 2 2 2 1 Glycosyl hydrolase family 81 C-terminal domain Glyco_hydro_81 PF03639.13 EMD66324.1 - 5.7e-110 367.5 3.1 7.8e-110 367.0 3.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 81 N-terminal domain Pertactin PF03212.14 EMD66324.1 - 0.14 12.1 3.5 0.94 9.4 0.1 3.2 3 0 0 3 3 3 0 Pertactin WW PF00397.26 EMD66325.1 - 0.00021 21.3 0.3 0.00021 21.3 0.3 2.6 3 0 0 3 3 3 1 WW domain Ammonium_transp PF00909.21 EMD66327.1 - 2.5e-115 385.4 28.5 2.9e-115 385.2 28.5 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family Clat_adaptor_s PF01217.20 EMD66329.1 - 4.6e-56 188.7 1.2 5.4e-56 188.5 1.2 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Sec23_trunk PF04811.15 EMD66330.1 - 3.5e-54 184.0 0.0 6.7e-54 183.0 0.0 1.5 1 1 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 EMD66330.1 - 6.9e-27 93.3 0.0 1.3e-26 92.4 0.0 1.5 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.12 EMD66330.1 - 4.1e-17 62.7 0.0 9e-17 61.6 0.0 1.6 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 EMD66330.1 - 5.9e-16 58.2 3.5 1.6e-15 56.8 3.5 1.8 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 EMD66330.1 - 5.5e-07 29.4 0.0 1e-06 28.6 0.0 1.5 1 0 0 1 1 1 1 Gelsolin repeat SLS PF14611.6 EMD66330.1 - 0.16 11.8 0.0 0.28 11.0 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial inner-membrane-bound regulator Ribosomal_L27A PF00828.19 EMD66331.1 - 3.6e-21 76.2 0.0 5.4e-21 75.6 0.0 1.3 1 1 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A GatB_N PF02934.15 EMD66333.1 - 1.8e-96 322.8 0.0 2.4e-96 322.3 0.0 1.2 1 0 0 1 1 1 1 GatB/GatE catalytic domain GatB_Yqey PF02637.18 EMD66333.1 - 1.7e-15 57.2 0.1 3.5e-15 56.2 0.1 1.5 1 0 0 1 1 1 1 GatB domain Inositol_P PF00459.25 EMD66334.1 - 8.6e-57 192.7 0.0 1.1e-56 192.4 0.0 1.1 1 0 0 1 1 1 1 Inositol monophosphatase family DUF3736 PF12540.8 EMD66334.1 - 0.32 11.1 2.6 0.77 9.9 2.6 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3736) RRM_1 PF00076.22 EMD66335.1 - 2.9e-16 59.0 0.0 4.8e-16 58.3 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) 6PGD PF00393.19 EMD66336.1 - 1.5e-128 428.2 0.0 1.9e-128 427.9 0.0 1.1 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 EMD66336.1 - 1e-48 165.5 0.1 1.5e-48 164.9 0.1 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 EMD66336.1 - 0.045 14.0 0.0 0.13 12.5 0.0 1.8 1 0 0 1 1 1 0 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase AD PF09793.9 EMD66337.1 - 7.2e-26 90.1 0.4 1.1e-25 89.6 0.4 1.2 1 0 0 1 1 1 1 Anticodon-binding domain TipAS PF07739.13 EMD66337.1 - 0.021 15.4 0.1 0.7 10.5 0.0 2.1 2 0 0 2 2 2 0 TipAS antibiotic-recognition domain Ank_4 PF13637.6 EMD66338.1 - 1.5e-12 47.8 0.2 1.5e-06 28.7 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 EMD66338.1 - 1.5e-09 37.9 1.0 0.0033 17.8 0.1 4.0 4 0 0 4 4 4 2 Ankyrin repeat Ank_2 PF12796.7 EMD66338.1 - 1.8e-09 38.1 0.2 9.2e-09 35.8 0.2 2.2 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EMD66338.1 - 0.0002 21.5 5.1 0.9 10.3 0.0 4.2 5 0 0 5 5 5 2 Ankyrin repeat Ank_5 PF13857.6 EMD66338.1 - 0.0025 18.1 0.4 2.4 8.6 0.0 3.8 1 1 2 3 3 3 2 Ankyrin repeats (many copies) LisH PF08513.11 EMD66338.1 - 0.14 12.2 0.0 0.3 11.1 0.0 1.6 1 0 0 1 1 1 0 LisH HET PF06985.11 EMD66339.1 - 5.3e-27 95.0 0.0 8.6e-27 94.3 0.0 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Glyco_transf_24 PF18404.1 EMD66340.1 - 4.2e-148 492.0 1.8 6.7e-148 491.3 1.8 1.3 1 0 0 1 1 1 1 Glucosyltransferase 24 Thioredoxin_14 PF18402.1 EMD66340.1 - 3e-69 233.8 0.0 2.1e-68 231.0 0.0 2.4 3 0 0 3 3 3 1 Thioredoxin-like domain Thioredoxin_15 PF18403.1 EMD66340.1 - 2.2e-54 184.6 0.1 1.1e-53 182.3 0.1 2.2 2 0 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_12 PF18400.1 EMD66340.1 - 8.3e-48 162.8 0.1 2.3e-47 161.4 0.1 1.8 1 0 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_13 PF18401.1 EMD66340.1 - 1e-41 142.0 0.1 4.4e-40 136.7 0.1 3.0 3 0 0 3 3 3 1 Thioredoxin-like domain UDP-g_GGTase PF06427.11 EMD66340.1 - 8.3e-39 132.1 0.0 1.7e-38 131.1 0.0 1.6 1 0 0 1 1 1 1 UDP-glucose:Glycoprotein Glucosyltransferase Glyco_transf_8 PF01501.20 EMD66340.1 - 0.00052 19.6 0.3 0.0011 18.6 0.3 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 8 DUF3431 PF11913.8 EMD66341.1 - 1.7e-85 286.2 0.3 2.1e-85 285.9 0.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3431) DNA_methylase PF00145.17 EMD66342.1 - 4.6e-25 88.7 0.0 5.5e-24 85.1 0.0 2.5 1 1 0 1 1 1 1 C-5 cytosine-specific DNA methylase BAH PF01426.18 EMD66342.1 - 2.9e-08 33.6 0.0 0.0036 17.2 0.0 2.6 2 1 0 2 2 2 2 BAH domain Amidohydro_2 PF04909.14 EMD66343.1 - 5.8e-06 26.3 0.0 9e-06 25.7 0.0 1.3 1 0 0 1 1 1 1 Amidohydrolase Amidohydro_1 PF01979.20 EMD66343.1 - 0.0002 20.8 0.0 0.00056 19.3 0.0 1.7 1 1 0 1 1 1 1 Amidohydrolase family CoA_binding_2 PF13380.6 EMD66343.1 - 0.072 13.6 0.1 0.78 10.3 0.0 2.5 2 1 1 3 3 3 0 CoA binding domain DENN PF02141.21 EMD66344.1 - 0.0031 17.5 0.5 0.062 13.3 0.5 2.3 1 1 0 1 1 1 1 DENN (AEX-3) domain SPA PF08616.10 EMD66344.1 - 0.0081 16.1 0.1 0.017 15.1 0.1 1.5 1 0 0 1 1 1 1 Stabilization of polarity axis Vac14_Fig4_bd PF11916.8 EMD66345.1 - 1.5e-80 269.0 8.3 1.5e-80 269.0 8.3 1.9 2 0 0 2 2 2 1 Vacuolar protein 14 C-terminal Fig4p binding Vac14_Fab1_bd PF12755.7 EMD66345.1 - 2e-45 153.3 0.1 2.1e-42 143.6 0.0 3.7 4 0 0 4 4 4 1 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 EMD66345.1 - 7.3e-10 39.1 2.3 0.058 13.9 0.1 5.6 5 0 0 5 5 5 2 HEAT-like repeat HEAT PF02985.22 EMD66345.1 - 6e-08 32.3 4.9 0.0011 19.0 0.0 5.3 6 0 0 6 6 6 2 HEAT repeat Cnd1 PF12717.7 EMD66345.1 - 3.3e-07 30.5 3.7 0.12 12.4 0.2 4.1 4 0 0 4 4 4 3 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EMD66345.1 - 3.3e-05 24.2 1.0 0.22 12.0 0.0 4.6 4 0 0 4 4 4 1 HEAT repeats Arm PF00514.23 EMD66345.1 - 0.0076 16.3 0.0 13 6.0 0.0 4.0 3 0 0 3 3 3 1 Armadillo/beta-catenin-like repeat DUF4672 PF15716.5 EMD66345.1 - 0.21 11.2 1.1 0.37 10.4 0.2 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4672) Vma12 PF11712.8 EMD66346.1 - 2.9e-44 150.5 0.0 2.2e-43 147.6 0.0 2.0 2 0 0 2 2 2 1 Endoplasmic reticulum-based factor for assembly of V-ATPase EptA_B_N PF08019.12 EMD66346.1 - 0.11 12.3 0.3 12 5.8 0.2 2.1 2 0 0 2 2 2 0 Phosphoethanolamine transferase EptA/EptB polyprenyl_synt PF00348.17 EMD66347.1 - 3.2e-72 242.7 0.0 5.4e-72 241.9 0.0 1.3 1 1 0 1 1 1 1 Polyprenyl synthetase DUF3659 PF12396.8 EMD66347.1 - 0.034 14.1 0.0 3.5 7.6 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3659) His_biosynth PF00977.21 EMD66348.1 - 9.7e-47 159.3 0.3 3.9e-46 157.3 0.3 2.0 1 1 0 1 1 1 1 Histidine biosynthesis protein GATase PF00117.28 EMD66348.1 - 2.4e-23 82.9 0.0 3.9e-23 82.2 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I SNO PF01174.19 EMD66348.1 - 1.7e-11 44.4 0.0 3.9e-08 33.4 0.0 2.3 2 0 0 2 2 2 2 SNO glutamine amidotransferase family GATase_3 PF07685.14 EMD66348.1 - 4.6e-08 32.9 0.0 9.3e-08 31.9 0.0 1.5 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain Peptidase_C26 PF07722.13 EMD66348.1 - 0.024 14.4 0.2 0.14 11.9 0.2 2.1 1 1 0 1 1 1 0 Peptidase C26 NMO PF03060.15 EMD66348.1 - 0.075 12.4 0.3 1 8.7 0.1 2.2 2 0 0 2 2 2 0 Nitronate monooxygenase Ribosomal_S4 PF00163.19 EMD66349.1 - 2.1e-12 47.8 0.2 3.1e-12 47.3 0.2 1.4 1 0 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain S4 PF01479.25 EMD66349.1 - 5.4e-11 42.0 0.0 9.4e-11 41.3 0.0 1.4 1 0 0 1 1 1 1 S4 domain HET PF06985.11 EMD66350.1 - 3.8e-33 114.9 0.1 6.5e-33 114.1 0.1 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) TRI12 PF06609.13 EMD66351.1 - 9.4e-59 199.4 21.2 1.3e-58 198.9 21.2 1.0 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_1 PF07690.16 EMD66351.1 - 6.5e-18 64.8 42.3 6.5e-18 64.8 42.3 2.4 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EMD66351.1 - 1.6e-14 53.7 2.3 1.6e-14 53.7 2.3 3.0 4 0 0 4 4 4 2 Sugar (and other) transporter Wzz PF02706.15 EMD66351.1 - 0.12 12.7 1.5 3.7 7.9 0.0 3.6 3 0 0 3 3 3 0 Chain length determinant protein Gpr1_Fun34_YaaH PF01184.19 EMD66352.1 - 5.1e-26 91.6 25.6 6.5e-26 91.2 25.6 1.0 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family DUF2721 PF11026.8 EMD66352.1 - 0.012 15.5 0.0 0.012 15.5 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2721) Pox_A14 PF05767.12 EMD66352.1 - 0.56 10.4 5.4 6.2 7.0 0.8 2.6 2 0 0 2 2 2 0 Poxvirus virion envelope protein A14 Cu-oxidase_2 PF07731.14 EMD66353.1 - 2.7e-44 150.2 9.2 2e-37 128.0 0.4 3.9 3 2 0 3 3 3 3 Multicopper oxidase Cu-oxidase_3 PF07732.15 EMD66353.1 - 2e-43 147.2 4.7 5.7e-39 132.8 1.3 2.8 2 0 0 2 2 2 2 Multicopper oxidase Cu-oxidase PF00394.22 EMD66353.1 - 8.9e-37 126.7 0.3 2.7e-36 125.1 0.3 1.9 1 0 0 1 1 1 1 Multicopper oxidase Cupin_5 PF06172.11 EMD66354.1 - 8.5e-40 136.2 0.0 1.1e-39 135.8 0.0 1.2 1 0 0 1 1 1 1 Cupin superfamily (DUF985) IU_nuc_hydro PF01156.19 EMD66355.1 - 3.2e-12 46.7 0.0 4e-12 46.3 0.0 1.1 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase Glyco_hydro_97 PF10566.9 EMD66355.1 - 0.12 11.7 0.8 15 4.7 1.4 2.2 2 0 0 2 2 2 0 Glycoside hydrolase 97 DUF2810 PF10928.8 EMD66355.1 - 0.99 9.5 0.1 0.99 9.5 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2810) Sugar_tr PF00083.24 EMD66356.1 - 7e-96 321.8 21.9 8.2e-96 321.6 21.9 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD66356.1 - 2e-20 73.1 32.7 2.3e-17 63.0 11.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EMD66356.1 - 0.011 14.2 1.1 0.023 13.1 1.1 1.4 1 0 0 1 1 1 0 Fungal trichothecene efflux pump (TRI12) Ac110_PIF PF07280.11 EMD66356.1 - 0.036 13.9 0.1 0.13 12.0 0.1 2.0 1 0 0 1 1 1 0 Per os infectivity factor AC110 Cir_N PF10197.9 EMD66357.1 - 0.00098 19.3 0.1 0.00098 19.3 0.1 4.2 4 1 0 4 4 4 1 N-terminal domain of CBF1 interacting co-repressor CIR RETICULATA-like PF11891.8 EMD66358.1 - 0.089 12.6 0.0 0.12 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein RETICULATA-related PRP1_N PF06424.12 EMD66359.1 - 7.8e-51 172.4 10.0 9.7e-51 172.1 8.4 2.1 2 0 0 2 2 2 1 PRP1 splicing factor, N-terminal TPR_19 PF14559.6 EMD66359.1 - 2e-26 92.3 3.0 2.6e-05 24.6 0.0 10.2 9 2 2 11 11 11 6 Tetratricopeptide repeat TPR_14 PF13428.6 EMD66359.1 - 4e-26 89.5 17.9 0.00054 20.6 0.0 14.0 4 3 12 16 16 16 7 Tetratricopeptide repeat TPR_2 PF07719.17 EMD66359.1 - 8.5e-10 38.0 1.9 13 6.2 0.0 10.9 13 0 0 13 13 13 0 Tetratricopeptide repeat TPR_16 PF13432.6 EMD66359.1 - 1.8e-08 34.9 4.6 0.14 12.8 0.0 7.4 4 1 4 8 8 8 2 Tetratricopeptide repeat TPR_1 PF00515.28 EMD66359.1 - 3.4e-05 23.5 0.1 1.5 8.8 0.0 5.6 7 0 0 7 7 7 1 Tetratricopeptide repeat Suf PF05843.14 EMD66359.1 - 5.5e-05 23.3 0.1 7.1 6.5 0.0 4.3 4 1 0 4 4 4 2 Suppressor of forked protein (Suf) TPR_8 PF13181.6 EMD66359.1 - 0.00028 20.9 0.9 5.5 7.5 0.0 7.0 9 0 0 9 9 7 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EMD66359.1 - 0.00042 20.5 0.0 4.5 7.6 0.0 4.3 3 1 1 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 EMD66359.1 - 0.00046 20.4 6.6 1.6 9.0 0.0 7.7 7 1 1 8 8 7 1 Tetratricopeptide repeat TPR_15 PF13429.6 EMD66359.1 - 0.0028 16.9 0.1 0.0028 16.9 0.1 5.2 3 2 1 5 5 5 1 Tetratricopeptide repeat TPR_6 PF13174.6 EMD66359.1 - 0.018 15.6 5.4 1.2e+02 3.6 0.1 7.6 8 1 0 8 8 8 0 Tetratricopeptide repeat DUF3808 PF10300.9 EMD66359.1 - 0.019 13.7 0.5 0.31 9.7 0.1 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3808) ChAPs PF09295.10 EMD66359.1 - 0.054 12.5 4.6 0.87 8.5 0.0 3.4 3 1 0 3 3 3 0 ChAPs (Chs5p-Arf1p-binding proteins) NRDE-2 PF08424.10 EMD66359.1 - 0.065 12.3 18.5 0.44 9.6 0.3 5.3 4 3 0 4 4 4 0 NRDE-2, necessary for RNA interference ABC_membrane PF00664.23 EMD66360.1 - 1.1e-43 149.8 11.7 1.4e-43 149.5 11.7 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 EMD66360.1 - 3.8e-36 124.6 0.0 8.4e-36 123.5 0.0 1.6 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 EMD66360.1 - 1.3e-06 28.0 0.0 0.00039 19.9 0.0 2.5 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 EMD66360.1 - 8.4e-06 26.3 0.0 2.1e-05 25.0 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_14 PF13173.6 EMD66360.1 - 0.0007 19.6 0.1 0.027 14.5 0.0 2.6 3 0 0 3 3 2 1 AAA domain AAA_22 PF13401.6 EMD66360.1 - 0.0027 18.0 0.1 0.063 13.6 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 EMD66360.1 - 0.0027 18.1 0.0 0.022 15.2 0.0 2.3 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.12 EMD66360.1 - 0.0052 16.1 0.0 0.02 14.2 0.0 2.0 1 0 0 1 1 1 1 Zeta toxin AAA_21 PF13304.6 EMD66360.1 - 0.0052 16.6 0.0 0.058 13.2 0.0 2.2 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EMD66360.1 - 0.014 15.2 0.1 0.039 13.7 0.1 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain NACHT PF05729.12 EMD66360.1 - 0.016 15.1 0.1 4.1 7.3 0.0 3.0 3 0 0 3 3 3 0 NACHT domain Rad17 PF03215.15 EMD66360.1 - 0.017 15.0 1.1 0.048 13.6 0.0 2.1 2 0 0 2 2 2 0 Rad17 P-loop domain AAA_25 PF13481.6 EMD66360.1 - 0.024 14.2 0.1 0.1 12.2 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 EMD66360.1 - 0.037 14.2 0.1 0.25 11.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 EMD66360.1 - 0.04 13.8 0.0 0.11 12.4 0.0 1.7 1 0 0 1 1 1 0 RsgA GTPase AAA_30 PF13604.6 EMD66360.1 - 0.046 13.4 0.0 0.14 11.9 0.0 1.9 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.6 EMD66360.1 - 0.049 13.9 0.1 0.22 11.8 0.0 2.1 1 1 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 EMD66360.1 - 0.054 13.6 0.1 0.25 11.5 0.0 2.2 3 0 0 3 3 2 0 50S ribosome-binding GTPase ATP-synt_ab PF00006.25 EMD66360.1 - 0.06 13.0 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_23 PF13476.6 EMD66360.1 - 0.062 13.8 0.0 0.062 13.8 0.0 1.9 3 0 0 3 3 2 0 AAA domain AAA_7 PF12775.7 EMD66360.1 - 0.067 12.7 0.0 0.16 11.5 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_18 PF13238.6 EMD66360.1 - 0.085 13.4 0.0 0.48 11.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 EMD66360.1 - 0.086 12.6 0.1 0.28 10.9 0.0 1.8 2 0 0 2 2 2 0 AAA domain TPR_1 PF00515.28 EMD66360.1 - 0.09 12.6 0.7 0.28 11.1 0.7 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat AIM24 PF01987.17 EMD66361.1 - 2.5e-52 177.6 0.2 3.1e-52 177.3 0.2 1.1 1 0 0 1 1 1 1 Mitochondrial biogenesis AIM24 DUF1983 PF09327.11 EMD66361.1 - 0.025 14.7 0.0 0.052 13.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1983) Gcn1_N PF12074.8 EMD66362.1 - 4.7e-121 404.4 18.7 1.4e-120 402.9 12.1 3.7 3 0 0 3 3 3 1 Generalcontrol nonderepressible 1 (Gcn1) N-terminal HEAT PF02985.22 EMD66362.1 - 1.4e-28 96.5 34.1 0.12 12.7 0.2 19.8 21 0 0 21 21 21 9 HEAT repeat HEAT_EZ PF13513.6 EMD66362.1 - 9.6e-27 93.0 47.6 1.8e-05 25.1 0.0 18.0 15 3 7 22 22 20 10 HEAT-like repeat HEAT_2 PF13646.6 EMD66362.1 - 4.4e-24 84.7 40.1 0.00016 22.0 2.7 13.7 9 4 4 14 14 14 9 HEAT repeats Cnd1 PF12717.7 EMD66362.1 - 6.2e-13 49.1 8.3 0.026 14.6 0.3 9.9 10 1 1 11 11 10 2 non-SMC mitotic condensation complex subunit 1 ParcG PF10274.9 EMD66362.1 - 9.1e-11 42.2 3.3 0.023 14.8 0.0 6.2 5 0 0 5 5 5 3 Parkin co-regulated protein Vac14_Fab1_bd PF12755.7 EMD66362.1 - 8.8e-08 32.6 0.3 22 5.8 0.1 8.4 8 2 4 12 12 10 0 Vacuolar 14 Fab1-binding region CLASP_N PF12348.8 EMD66362.1 - 4.7e-07 29.6 0.0 0.098 12.2 0.0 5.9 5 2 2 7 7 7 1 CLASP N terminal FANCI_S2 PF14676.6 EMD66362.1 - 0.0063 16.8 0.9 0.32 11.3 0.1 3.8 4 0 0 4 4 4 1 FANCI solenoid 2 TAF6_C PF07571.13 EMD66362.1 - 0.02 15.2 0.9 5.9 7.3 0.0 5.5 5 2 1 6 6 6 0 TAF6 C-terminal HEAT repeat domain DRIM PF07539.12 EMD66362.1 - 0.43 8.8 15.5 1.4 7.1 0.1 4.6 4 2 1 5 5 5 0 Down-regulated in metastasis DUF937 PF06078.11 EMD66362.1 - 0.82 10.3 10.7 41 4.8 0.1 6.4 6 2 0 6 6 6 0 Bacterial protein of unknown function (DUF937) MMS19_C PF12460.8 EMD66362.1 - 0.83 8.7 28.4 0.22 10.6 0.1 7.2 7 2 0 8 8 8 0 RNAPII transcription regulator C-terminal WASH-7_C PF14746.6 EMD66362.1 - 1.2 8.8 3.1 1.7 8.3 1.3 2.1 2 0 0 2 2 2 0 WASH complex subunit 7, C-terminal RIX1 PF08167.12 EMD66362.1 - 2.3 7.9 7.0 3.7 7.2 0.2 4.7 6 0 0 6 6 5 0 rRNA processing/ribosome biogenesis SAGA-Tad1 PF12767.7 EMD66363.1 - 1.2e-51 175.7 0.0 2.4e-51 174.7 0.0 1.5 2 0 0 2 2 2 1 Transcriptional regulator of RNA polII, SAGA, subunit WD40 PF00400.32 EMD66364.1 - 6.3e-16 58.5 16.6 0.009 16.9 0.3 6.3 6 0 0 6 6 6 5 WD domain, G-beta repeat DLH PF01738.18 EMD66365.1 - 2.5e-26 92.6 0.0 3e-26 92.3 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_1 PF00561.20 EMD66365.1 - 0.004 16.8 0.0 0.017 14.8 0.0 1.8 2 0 0 2 2 2 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EMD66365.1 - 0.077 12.5 0.0 0.21 11.0 0.0 1.7 2 0 0 2 2 2 0 Prolyl oligopeptidase family WD40 PF00400.32 EMD66367.1 - 1.1e-36 124.2 24.7 3.6e-05 24.4 0.5 11.3 11 0 0 11 11 11 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD66367.1 - 4.3e-18 65.4 0.8 4e-05 23.8 0.0 6.3 3 3 2 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain PQQ PF01011.21 EMD66367.1 - 0.00032 20.5 1.2 2.8 8.0 0.1 4.3 4 0 0 4 4 4 2 PQQ enzyme repeat PQQ_3 PF13570.6 EMD66367.1 - 0.00047 20.6 12.5 0.13 12.8 0.0 6.5 7 0 0 7 7 7 2 PQQ-like domain WD40_like PF17005.5 EMD66367.1 - 0.0091 15.3 0.0 2.3 7.5 0.0 2.8 1 1 1 2 2 2 2 WD40-like domain PD40 PF07676.12 EMD66367.1 - 0.011 15.6 2.0 9.6 6.3 0.1 4.0 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Adeno_PV PF03910.13 EMD66369.1 - 0.019 13.7 2.2 0.023 13.4 2.2 1.0 1 0 0 1 1 1 0 Adenovirus minor core protein PV COesterase PF00135.28 EMD66370.1 - 2.9e-92 310.2 0.0 3.2e-92 310.1 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EMD66370.1 - 1.8e-05 24.7 0.3 7.4e-05 22.7 0.3 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold MFS_1 PF07690.16 EMD66371.1 - 4.3e-33 114.7 37.3 5.9e-33 114.3 37.3 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_4 PF06779.14 EMD66371.1 - 6.9e-07 28.9 22.8 1e-06 28.3 9.8 2.1 2 0 0 2 2 2 2 Uncharacterised MFS-type transporter YbfB PNTB PF02233.16 EMD66371.1 - 0.043 12.7 3.8 0.022 13.7 1.3 1.8 1 1 1 2 2 2 0 NAD(P) transhydrogenase beta subunit KR PF08659.10 EMD66372.1 - 4.8e-05 23.3 0.6 0.00024 21.1 0.0 2.2 3 0 0 3 3 3 1 KR domain Peptidase_S8 PF00082.22 EMD66373.1 - 3.6e-45 154.5 0.0 8e-45 153.4 0.0 1.5 1 1 0 1 1 1 1 Subtilase family fn3_5 PF06280.12 EMD66373.1 - 3.2e-12 47.1 0.4 5.7e-12 46.3 0.0 1.6 2 0 0 2 2 2 1 Fn3-like domain NPCBM_assoc PF10633.9 EMD66373.1 - 0.028 14.7 0.9 0.093 13.0 0.2 2.2 2 0 0 2 2 2 0 NPCBM-associated, NEW3 domain of alpha-galactosidase FAD_binding_3 PF01494.19 EMD66374.1 - 9.4e-27 94.2 0.0 8.3e-26 91.0 0.0 2.0 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 EMD66374.1 - 3.7e-05 23.9 0.2 8.7e-05 22.7 0.2 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EMD66374.1 - 3.8e-05 23.0 0.1 0.052 12.8 0.1 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EMD66374.1 - 0.00064 19.4 0.2 0.0092 15.6 0.3 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EMD66374.1 - 0.00077 18.8 0.0 0.26 10.5 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EMD66374.1 - 0.0009 18.2 0.6 0.21 10.4 0.1 2.4 2 1 1 3 3 3 2 Tryptophan halogenase HI0933_like PF03486.14 EMD66374.1 - 0.001 17.9 0.1 0.027 13.2 0.1 2.2 2 0 0 2 2 2 1 HI0933-like protein SE PF08491.10 EMD66374.1 - 0.0012 18.0 0.0 0.004 16.2 0.0 1.8 2 0 0 2 2 2 1 Squalene epoxidase Pyr_redox PF00070.27 EMD66374.1 - 0.011 16.2 0.3 0.21 12.2 0.2 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 EMD66374.1 - 0.016 14.5 0.0 0.025 13.9 0.0 1.3 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase FAD_binding_2 PF00890.24 EMD66374.1 - 0.078 12.0 0.0 0.15 11.1 0.0 1.4 1 0 0 1 1 1 0 FAD binding domain GIDA PF01134.22 EMD66374.1 - 0.2 10.7 0.1 16 4.4 0.1 2.1 2 0 0 2 2 2 0 Glucose inhibited division protein A adh_short PF00106.25 EMD66375.1 - 1.6e-28 99.5 0.0 2.3e-28 99.0 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD66375.1 - 1e-19 71.0 0.0 1.6e-19 70.4 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.6 EMD66375.1 - 1.1e-06 28.7 0.1 3.3e-06 27.1 0.1 1.8 1 1 0 1 1 1 1 NAD(P)H-binding KR PF08659.10 EMD66375.1 - 1.2e-06 28.5 0.0 2.5e-06 27.5 0.0 1.4 2 0 0 2 2 2 1 KR domain NmrA PF05368.13 EMD66375.1 - 0.0011 18.6 0.1 0.0019 17.8 0.1 1.3 1 0 0 1 1 1 1 NmrA-like family GDP_Man_Dehyd PF16363.5 EMD66375.1 - 0.0022 17.5 0.0 0.0038 16.7 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 EMD66375.1 - 0.012 15.1 0.0 0.035 13.6 0.0 1.7 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family TrkA_N PF02254.18 EMD66375.1 - 0.039 14.2 0.1 0.14 12.4 0.0 1.9 2 1 1 3 3 3 0 TrkA-N domain 3Beta_HSD PF01073.19 EMD66375.1 - 0.18 10.8 0.0 0.34 9.9 0.0 1.4 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family MBOAT_2 PF13813.6 EMD66376.1 - 8.6e-25 86.8 2.5 2.8e-24 85.2 2.5 1.9 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family Fungal_trans_2 PF11951.8 EMD66377.1 - 2.6e-40 138.4 10.3 1.2e-36 126.4 5.0 2.2 2 0 0 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD66377.1 - 1.2e-06 28.5 9.7 1.2e-06 28.5 9.7 2.6 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain UbiA PF01040.18 EMD66378.1 - 7.1e-39 133.6 19.4 9.5e-39 133.2 19.4 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family DUF3796 PF12676.7 EMD66378.1 - 0.002 18.5 0.1 0.0059 17.0 0.1 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3796) ketoacyl-synt PF00109.26 EMD66379.1 - 2.9e-64 217.1 1.8 3.6e-64 216.8 0.3 2.0 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain SAT PF16073.5 EMD66379.1 - 1.3e-55 188.8 0.9 3.3e-55 187.4 0.1 2.1 2 1 0 2 2 2 1 Starter unit:ACP transacylase in aflatoxin biosynthesis Acyl_transf_1 PF00698.21 EMD66379.1 - 1.8e-42 146.0 0.2 3.7e-42 145.0 0.2 1.5 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EMD66379.1 - 8.4e-35 119.3 0.3 3.3e-34 117.4 0.4 2.0 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain Thioesterase PF00975.20 EMD66379.1 - 2.4e-26 93.3 0.0 5.7e-26 92.1 0.0 1.6 1 0 0 1 1 1 1 Thioesterase domain PS-DH PF14765.6 EMD66379.1 - 2.9e-18 66.1 0.0 5.5e-18 65.2 0.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase PP-binding PF00550.25 EMD66379.1 - 8.2e-10 38.9 0.2 2.4e-09 37.4 0.2 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site KAsynt_C_assoc PF16197.5 EMD66379.1 - 0.00013 22.4 0.0 0.00031 21.2 0.0 1.6 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Thiolase_N PF00108.23 EMD66379.1 - 0.12 11.7 0.0 0.3 10.4 0.0 1.6 1 0 0 1 1 1 0 Thiolase, N-terminal domain Abhydrolase_6 PF12697.7 EMD66379.1 - 0.12 12.9 8.3 0.019 15.6 1.1 3.0 3 0 0 3 3 3 0 Alpha/beta hydrolase family ketoacyl-synt PF00109.26 EMD66380.1 - 6.9e-66 222.4 0.0 1.7e-65 221.1 0.0 1.8 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain PS-DH PF14765.6 EMD66380.1 - 4.4e-60 203.4 0.0 7.4e-60 202.7 0.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase KR PF08659.10 EMD66380.1 - 1.2e-55 188.3 1.2 3.1e-55 186.9 0.6 2.1 2 0 0 2 2 2 1 KR domain Acyl_transf_1 PF00698.21 EMD66380.1 - 7e-51 173.6 0.0 1.1e-50 172.9 0.0 1.2 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EMD66380.1 - 4.4e-34 117.0 0.3 1.2e-33 115.6 0.3 1.9 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 EMD66380.1 - 7.2e-24 84.4 0.0 1.6e-23 83.3 0.0 1.7 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Methyltransf_12 PF08242.12 EMD66380.1 - 5.2e-20 72.0 0.0 1.3e-19 70.7 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EMD66380.1 - 1e-10 41.7 0.0 2.5e-10 40.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMD66380.1 - 1.3e-10 41.9 0.0 1.3e-09 38.6 0.0 2.6 2 0 0 2 2 2 1 Methyltransferase domain ADH_zinc_N PF00107.26 EMD66380.1 - 2.9e-09 37.0 0.1 1.2e-08 35.0 0.1 2.1 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Methyltransf_11 PF08241.12 EMD66380.1 - 4.5e-09 36.8 0.0 1.4e-08 35.3 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMD66380.1 - 1.1e-08 35.0 0.0 9.9e-08 31.9 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain adh_short PF00106.25 EMD66380.1 - 1.3e-07 31.2 3.0 2.1e-07 30.6 0.1 2.6 3 0 0 3 3 3 1 short chain dehydrogenase ADH_zinc_N_2 PF13602.6 EMD66380.1 - 1.1e-05 26.5 0.0 0.00012 23.1 0.0 2.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EMD66380.1 - 0.00021 21.1 0.1 0.00046 20.0 0.1 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Ubie_methyltran PF01209.18 EMD66380.1 - 0.0011 18.4 0.0 0.0021 17.4 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family PP-binding PF00550.25 EMD66380.1 - 0.02 15.3 0.2 0.053 13.9 0.2 1.8 1 0 0 1 1 1 0 Phosphopantetheine attachment site Methyltransf_16 PF10294.9 EMD66380.1 - 0.12 12.1 0.0 1.3 8.7 0.0 2.6 2 0 0 2 2 2 0 Lysine methyltransferase PALP PF00291.25 EMD66380.1 - 0.24 10.8 1.6 0.48 9.8 0.3 2.1 2 0 0 2 2 2 0 Pyridoxal-phosphate dependent enzyme SQHop_cyclase_C PF13243.6 EMD66381.1 - 6.4e-48 163.5 2.5 4.9e-46 157.3 1.6 2.2 2 0 0 2 2 2 2 Squalene-hopene cyclase C-terminal domain SQHop_cyclase_N PF13249.6 EMD66381.1 - 1.4e-28 99.9 5.1 2.8e-25 89.0 0.2 4.4 3 1 2 5 5 5 2 Squalene-hopene cyclase N-terminal domain Prenyltrans PF00432.21 EMD66381.1 - 2.7e-22 78.2 12.3 3.8e-08 32.9 0.2 4.9 5 0 0 5 5 5 3 Prenyltransferase and squalene oxidase repeat Pec_lyase PF09492.10 EMD66381.1 - 7.3e-05 22.2 0.2 0.42 9.9 0.1 3.4 1 1 2 3 3 3 2 Pectic acid lyase DUF3575 PF12099.8 EMD66381.1 - 0.029 13.7 0.0 0.1 11.9 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3575) Mago-bind PF09282.10 EMD66381.1 - 0.14 12.0 0.0 0.44 10.5 0.0 1.9 2 0 0 2 2 2 0 Mago binding FAD_binding_3 PF01494.19 EMD66382.1 - 6.5e-20 71.7 0.2 1.9e-19 70.1 0.2 1.7 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EMD66382.1 - 1e-08 34.8 1.2 0.00011 21.6 0.1 2.3 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EMD66382.1 - 3.1e-06 27.0 8.0 0.0029 17.3 1.3 2.7 1 1 1 3 3 3 2 FAD dependent oxidoreductase Trp_halogenase PF04820.14 EMD66382.1 - 4.4e-05 22.5 3.7 0.037 12.9 0.5 3.1 2 1 1 3 3 3 2 Tryptophan halogenase FAD_binding_2 PF00890.24 EMD66382.1 - 6.6e-05 22.2 2.7 8e-05 21.9 1.3 1.8 1 1 1 2 2 2 1 FAD binding domain NAD_binding_8 PF13450.6 EMD66382.1 - 9.4e-05 22.6 0.1 0.00024 21.3 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 EMD66382.1 - 0.0017 17.7 0.3 0.53 9.5 0.0 2.3 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase HI0933_like PF03486.14 EMD66382.1 - 0.0019 17.0 1.0 0.022 13.5 0.2 2.1 2 0 0 2 2 2 1 HI0933-like protein FAD_oxidored PF12831.7 EMD66382.1 - 0.0025 17.3 1.1 0.0037 16.7 1.1 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 EMD66382.1 - 0.004 17.7 1.3 0.048 14.2 0.7 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EMD66382.1 - 0.052 12.6 0.4 0.064 12.3 0.4 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A Lycopene_cycl PF05834.12 EMD66382.1 - 0.061 12.4 3.7 0.19 10.8 0.7 2.3 2 1 0 2 2 2 0 Lycopene cyclase protein Thi4 PF01946.17 EMD66382.1 - 0.078 12.2 0.2 0.078 12.2 0.2 1.5 2 0 0 2 2 2 0 Thi4 family AlaDh_PNT_C PF01262.21 EMD66382.1 - 0.11 11.8 0.7 0.66 9.2 0.1 2.2 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_3 PF01494.19 EMD66383.1 - 2.3e-24 86.3 0.1 1.2e-23 83.9 0.1 1.9 1 1 0 1 1 1 1 FAD binding domain Amino_oxidase PF01593.24 EMD66383.1 - 1.5e-07 31.1 0.1 0.011 15.1 0.0 2.3 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase Lycopene_cycl PF05834.12 EMD66383.1 - 6.3e-05 22.2 0.6 0.00063 18.9 0.6 2.0 1 1 0 1 1 1 1 Lycopene cyclase protein Pyr_redox PF00070.27 EMD66383.1 - 0.00036 21.0 0.6 0.013 16.1 0.3 3.1 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EMD66383.1 - 0.00058 20.0 0.5 0.0017 18.6 0.5 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EMD66383.1 - 0.0011 18.3 0.1 0.0031 16.8 0.0 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EMD66383.1 - 0.011 14.8 0.4 0.019 14.1 0.4 1.3 1 0 0 1 1 1 0 FAD binding domain Pyr_redox_3 PF13738.6 EMD66383.1 - 0.012 14.9 0.2 0.086 12.1 0.2 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EMD66383.1 - 0.013 15.1 0.4 0.035 13.7 0.4 1.6 1 1 1 2 2 2 0 FAD dependent oxidoreductase AFOR_N PF02730.15 EMD66383.1 - 0.079 12.8 0.2 1.4 8.7 0.0 2.3 2 0 0 2 2 2 0 Aldehyde ferredoxin oxidoreductase, N-terminal domain FMN_red PF03358.15 EMD66384.1 - 5e-32 110.8 0.0 6.2e-32 110.5 0.0 1.1 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 EMD66384.1 - 0.00045 20.0 0.0 0.00058 19.6 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin-like fold p450 PF00067.22 EMD66385.1 - 1.7e-37 129.2 0.0 2.5e-37 128.7 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 DUF3435 PF11917.8 EMD66386.1 - 3.2e-142 474.3 0.1 3.8e-142 474.1 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3435) Phage_integrase PF00589.22 EMD66386.1 - 0.057 13.2 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 Phage integrase family zf-C2H2_4 PF13894.6 EMD66386.1 - 0.33 11.9 2.2 12 7.1 0.4 2.9 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_4 PF13894.6 EMD66387.1 - 4.5e-10 39.5 26.7 0.047 14.5 0.5 7.8 6 1 1 7 7 7 4 C2H2-type zinc finger zf-C2H2 PF00096.26 EMD66387.1 - 7.4e-09 35.6 32.9 0.0052 17.2 0.9 7.2 6 1 1 7 7 7 4 Zinc finger, C2H2 type zf-C2H2_2 PF12756.7 EMD66387.1 - 4.6e-05 23.7 23.4 0.0043 17.4 0.1 5.0 2 1 3 5 5 5 2 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.8 EMD66387.1 - 0.0034 17.6 36.2 0.026 14.8 1.3 6.8 8 1 0 8 8 8 4 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EMD66387.1 - 0.0056 17.0 25.8 1.7 9.1 0.6 7.1 6 1 0 6 6 6 3 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 EMD66387.1 - 1.5 8.9 22.5 4.9 7.3 0.2 5.7 6 0 0 6 6 6 0 C2H2-type zinc finger OTT_1508_deam PF14441.6 EMD66388.1 - 5.2e-19 68.0 3.2 5.2e-19 68.0 3.2 2.0 2 0 0 2 2 2 1 OTT_1508-like deaminase BTB PF00651.31 EMD66389.1 - 3.1e-12 46.7 0.1 4.6e-12 46.2 0.1 1.3 1 0 0 1 1 1 1 BTB/POZ domain Ntox8 PF15545.6 EMD66389.1 - 0.0044 17.1 0.1 0.039 14.1 0.0 2.1 2 0 0 2 2 2 1 Bacterial toxin 8 DDE_1 PF03184.19 EMD66390.1 - 1.6e-23 83.3 0.0 3.2e-21 75.8 0.0 2.0 1 1 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.6 EMD66390.1 - 0.0019 18.0 0.0 0.0028 17.4 0.0 1.5 1 1 0 1 1 1 1 DDE superfamily endonuclease NACHT PF05729.12 EMD66392.1 - 6.2e-13 49.0 0.1 3.5e-12 46.6 0.1 2.4 3 0 0 3 3 3 1 NACHT domain AAA_22 PF13401.6 EMD66392.1 - 4.9e-07 30.1 0.0 1.8e-06 28.3 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EMD66392.1 - 6.9e-06 26.5 0.0 6.2e-05 23.5 0.0 2.5 1 1 1 2 2 2 1 AAA ATPase domain Ank_2 PF12796.7 EMD66392.1 - 0.00052 20.5 1.1 0.094 13.3 0.0 3.6 4 0 0 4 4 4 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EMD66392.1 - 0.00059 20.1 0.5 0.09 13.1 0.0 3.5 2 1 1 3 3 3 1 Ankyrin repeats (many copies) KAP_NTPase PF07693.14 EMD66392.1 - 0.01 15.1 0.1 0.044 13.0 0.2 1.9 1 1 0 2 2 2 0 KAP family P-loop domain Ank_4 PF13637.6 EMD66392.1 - 0.02 15.5 2.9 1.4 9.6 0.3 3.8 3 1 0 3 3 3 0 Ankyrin repeats (many copies) ATPase_2 PF01637.18 EMD66392.1 - 0.055 13.4 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea Ank_3 PF13606.6 EMD66392.1 - 0.086 13.4 3.7 41 5.2 0.0 4.9 5 0 0 5 5 5 0 Ankyrin repeat AAA PF00004.29 EMD66392.1 - 0.11 12.9 0.2 0.67 10.4 0.0 2.5 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) SWIM PF04434.17 EMD66395.1 - 7.3e-08 31.9 0.8 1.4e-07 31.0 0.8 1.4 1 0 0 1 1 1 1 SWIM zinc finger Smg4_UPF3 PF03467.15 EMD66396.1 - 0.064 13.3 2.4 0.11 12.5 1.3 1.9 1 1 1 2 2 2 0 Smg-4/UPF3 family DUF2281 PF10047.9 EMD66396.1 - 0.14 12.9 0.4 0.44 11.3 0.4 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF2281) APH PF01636.23 EMD66397.1 - 1.7e-11 44.5 0.0 2.5e-11 44.0 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EMD66397.1 - 0.0013 18.4 0.0 0.0023 17.6 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase Pkinase PF00069.25 EMD66397.1 - 0.0025 17.2 0.0 0.036 13.4 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD66397.1 - 0.11 11.7 0.0 0.22 10.8 0.0 1.4 1 0 0 1 1 1 0 Protein tyrosine kinase Pox_ser-thr_kin PF05445.11 EMD66397.1 - 0.13 11.2 0.0 0.19 10.7 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Mito_fiss_reg PF05308.11 EMD66397.1 - 1.9 8.5 5.6 1.6 8.7 2.8 2.0 2 0 0 2 2 2 0 Mitochondrial fission regulator PRIMA1 PF16101.5 EMD66397.1 - 9.5 6.3 12.2 15 5.6 12.2 1.3 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 zf-C2H2_4 PF13894.6 EMD66398.1 - 2.1e-10 40.6 21.2 0.018 15.8 0.2 6.4 6 0 0 6 6 6 3 C2H2-type zinc finger zf-C2H2 PF00096.26 EMD66398.1 - 3.7e-06 27.1 34.6 0.0044 17.4 0.2 5.8 7 0 0 7 7 7 4 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 EMD66398.1 - 0.00017 21.5 24.4 0.022 14.8 1.0 5.4 5 0 0 5 5 5 2 C2H2-type zinc finger zf-C2HE PF16278.5 EMD66398.1 - 0.023 15.2 10.3 2 8.9 1.1 4.0 3 1 1 4 4 4 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_jaz PF12171.8 EMD66398.1 - 0.023 15.0 21.7 0.34 11.2 0.1 5.4 5 1 1 6 6 6 0 Zinc-finger double-stranded RNA-binding zf-C2H2_8 PF15909.5 EMD66398.1 - 0.036 14.4 5.9 0.17 12.2 0.8 2.8 3 0 0 3 3 3 0 C2H2-type zinc ribbon Zn-ribbon_8 PF09723.10 EMD66398.1 - 0.14 12.3 0.2 0.14 12.3 0.2 4.1 3 2 1 4 4 4 0 Zinc ribbon domain zf-C2H2_2 PF12756.7 EMD66398.1 - 0.18 12.2 17.9 1.1 9.7 1.1 4.8 1 1 1 4 4 4 0 C2H2 type zinc-finger (2 copies) zf-C2H2_9 PF16293.5 EMD66398.1 - 0.79 9.6 5.6 23 4.9 0.0 3.7 3 1 1 4 4 4 0 C2H2 type zinc-finger (1 copy) zf-C2HC_2 PF13913.6 EMD66398.1 - 1 9.3 9.0 8.4 6.4 0.2 3.8 3 0 0 3 3 3 0 zinc-finger of a C2HC-type zf-met PF12874.7 EMD66398.1 - 2.4 8.6 16.0 5.9 7.4 0.1 5.8 6 0 0 6 6 6 0 Zinc-finger of C2H2 type TPR_10 PF13374.6 EMD66402.1 - 1.6e-43 145.4 4.7 8.6e-13 47.7 0.0 5.0 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_12 PF13424.6 EMD66402.1 - 3.2e-38 129.9 3.0 1.4e-15 57.4 0.0 4.2 2 2 2 4 4 4 4 Tetratricopeptide repeat TPR_7 PF13176.6 EMD66402.1 - 4e-11 42.1 0.1 0.033 14.2 0.0 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 EMD66402.1 - 1.2e-08 34.4 0.1 0.15 11.9 0.0 4.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 EMD66402.1 - 0.00014 21.8 0.6 0.78 10.1 0.1 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 EMD66402.1 - 0.00022 21.4 1.9 9.8 6.8 0.1 4.3 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_2 PF07719.17 EMD66402.1 - 0.01 15.9 2.4 25 5.3 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_16 PF13432.6 EMD66402.1 - 0.042 14.5 0.0 5.7 7.7 0.0 3.4 3 1 1 4 4 4 0 Tetratricopeptide repeat DUF4554 PF15091.6 EMD66402.1 - 0.065 12.1 0.0 0.17 10.8 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4554) DUF627 PF04781.12 EMD66402.1 - 0.084 12.9 1.3 2.6 8.1 0.1 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF627) TPR_MalT PF17874.1 EMD66402.1 - 0.18 11.2 4.4 0.5 9.7 4.4 1.7 1 1 0 1 1 1 0 MalT-like TPR region DUF1996 PF09362.10 EMD66404.1 - 2e-40 139.3 0.0 3.9e-40 138.3 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1996) Peptidase_M24 PF00557.24 EMD66404.1 - 0.035 13.8 0.1 0.053 13.2 0.1 1.3 1 0 0 1 1 1 0 Metallopeptidase family M24 NAD_binding_6 PF08030.12 EMD66405.1 - 2.9e-09 37.2 0.0 2e-08 34.5 0.0 1.9 1 1 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EMD66405.1 - 2.1e-06 27.8 0.0 4.2e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 FAD-binding domain AIG1 PF04548.16 EMD66406.1 - 0.041 13.2 0.0 0.058 12.7 0.0 1.2 1 0 0 1 1 1 0 AIG1 family Spc7 PF08317.11 EMD66408.1 - 0.017 14.0 13.8 0.42 9.5 5.2 2.5 1 1 1 2 2 2 0 Spc7 kinetochore protein Tropomyosin PF00261.20 EMD66408.1 - 0.027 13.9 1.9 0.027 13.9 1.9 2.2 2 0 0 2 2 2 0 Tropomyosin Flp_N PF03930.14 EMD66408.1 - 0.036 14.0 0.3 0.31 11.0 0.0 2.1 2 0 0 2 2 2 0 Recombinase Flp protein N-terminus Filament PF00038.21 EMD66408.1 - 0.038 13.6 12.5 0.052 13.1 4.7 2.2 2 0 0 2 2 2 0 Intermediate filament protein LPP PF04728.13 EMD66408.1 - 0.062 13.7 7.5 0.4 11.1 0.3 2.9 3 0 0 3 3 3 0 Lipoprotein leucine-zipper MbeD_MobD PF04899.12 EMD66408.1 - 0.093 12.9 0.5 0.093 12.9 0.5 2.3 2 0 0 2 2 2 0 MbeD/MobD like GAS PF13851.6 EMD66408.1 - 0.095 12.0 14.7 0.14 11.5 4.3 2.3 2 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding PHM7_cyt PF14703.6 EMD66408.1 - 0.26 11.5 4.7 0.2 11.9 0.6 2.2 2 1 0 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter Mis14 PF08641.12 EMD66408.1 - 0.37 11.1 7.1 0.6 10.4 0.6 2.9 2 2 0 2 2 2 0 Kinetochore protein Mis14 like HIP1_clath_bdg PF16515.5 EMD66408.1 - 0.55 10.9 17.3 1.6 9.4 3.5 2.3 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Occludin_ELL PF07303.13 EMD66408.1 - 0.76 10.5 8.4 0.53 11.0 1.4 2.6 2 2 0 2 2 2 0 Occludin homology domain DivIVA PF05103.13 EMD66408.1 - 1.6 8.9 14.0 0.16 12.1 1.4 3.1 1 1 1 3 3 3 0 DivIVA protein BST2 PF16716.5 EMD66408.1 - 4 8.1 11.8 0.89 10.2 0.6 2.8 2 2 0 2 2 2 0 Bone marrow stromal antigen 2 SCAB_CC PF16712.5 EMD66408.1 - 4.2 7.2 13.3 1.2 8.9 2.1 3.2 1 1 2 3 3 3 0 Coiled-coil regions of plant-specific actin-binding protein SpecificRecomb PF10136.9 EMD66408.1 - 4.7 5.4 6.9 7.6 4.7 6.7 1.4 1 1 0 1 1 1 0 Site-specific recombinase CALM_bind PF16025.5 EMD66408.1 - 9.7 6.7 7.9 2.2 8.8 1.5 2.8 2 2 0 2 2 2 0 Calcium-dependent calmodulin binding YgaB PF14182.6 EMD66409.1 - 0.033 14.6 0.1 0.067 13.6 0.1 1.5 1 0 0 1 1 1 0 YgaB-like protein Med2 PF11214.8 EMD66409.1 - 0.086 13.0 0.1 0.12 12.5 0.1 1.3 1 0 0 1 1 1 0 Mediator complex subunit 2 UL21a PF17636.2 EMD66410.1 - 0.18 11.8 0.0 0.39 10.7 0.0 1.5 1 0 0 1 1 1 0 Viral Unique Long protein 21a DUF3723 PF12520.8 EMD66411.1 - 4.8e-53 180.6 1.2 6.2e-53 180.2 1.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3723) Amb_V_allergen PF03913.13 EMD66411.1 - 0.038 13.9 0.1 0.095 12.7 0.1 1.6 1 0 0 1 1 1 0 Amb V Allergen bZIP_1 PF00170.21 EMD66412.1 - 1.6 8.9 7.5 1 9.5 5.7 1.7 2 0 0 2 2 2 0 bZIP transcription factor BTB PF00651.31 EMD66413.1 - 1.6e-06 28.3 0.0 3.7e-06 27.1 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain RSN1_7TM PF02714.15 EMD66414.1 - 6.1e-51 173.3 13.3 7.8e-46 156.6 5.6 2.6 3 0 0 3 3 3 2 Calcium-dependent channel, 7TM region, putative phosphate PHM7_cyt PF14703.6 EMD66414.1 - 4.2e-20 72.7 0.0 6.2e-20 72.1 0.0 1.3 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter RSN1_TM PF13967.6 EMD66414.1 - 9.3e-19 67.7 2.9 7.3e-18 64.8 2.9 2.5 1 1 0 1 1 1 1 Late exocytosis, associated with Golgi transport Asp PF00026.23 EMD66418.1 - 1.8e-06 27.6 0.0 2.4e-06 27.2 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease PX PF00787.24 EMD66420.1 - 0.05 13.6 0.0 0.079 12.9 0.0 1.3 1 0 0 1 1 1 0 PX domain Mo-co_dimer PF03404.16 EMD66420.1 - 0.077 13.0 0.1 0.11 12.5 0.1 1.4 1 1 0 1 1 1 0 Mo-co oxidoreductase dimerisation domain LD_cluster2 PF18163.1 EMD66421.1 - 0.18 11.3 0.6 0.57 9.7 0.3 1.7 2 0 0 2 2 2 0 SLOG cluster2 Apo-CIII PF05778.12 EMD66423.1 - 1.2 8.9 4.9 8.8 6.0 0.0 3.6 3 1 1 4 4 4 0 Apolipoprotein CIII (Apo-CIII) HEPN-like_int PF18867.1 EMD66424.1 - 0.062 13.2 0.0 0.1 12.5 0.0 1.3 1 0 0 1 1 1 0 HEPN-like integron domain zf-C2HC_2 PF13913.6 EMD66426.1 - 0.045 13.7 2.9 0.079 12.9 1.8 2.0 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf-C2H2 PF00096.26 EMD66426.1 - 0.046 14.2 4.5 0.053 14.0 2.7 2.1 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMD66426.1 - 0.12 13.3 3.5 0.23 12.4 2.1 2.3 2 0 0 2 2 2 0 C2H2-type zinc finger DUF3465 PF11948.8 EMD66426.1 - 0.17 11.8 0.0 0.28 11.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3465) APH PF01636.23 EMD66430.1 - 6.1e-14 52.5 0.0 2.5e-13 50.5 0.0 1.8 1 1 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EMD66430.1 - 0.013 15.1 0.0 0.021 14.4 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase Pkinase_fungal PF17667.1 EMD66431.1 - 0.021 13.6 0.0 0.026 13.3 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase OTT_1508_deam PF14441.6 EMD66432.1 - 1.9e-17 63.0 0.3 4.5e-17 61.8 0.3 1.7 1 0 0 1 1 1 1 OTT_1508-like deaminase Q_salvage PF10343.9 EMD66432.1 - 0.053 13.1 0.6 4.7 6.7 0.0 2.4 1 1 1 2 2 2 0 Potential Queuosine, Q, salvage protein family Takusan PF04822.13 EMD66432.1 - 6.4 6.7 6.4 3.9 7.4 0.0 3.3 3 0 0 3 3 3 0 Takusan Myb_DNA-binding PF00249.31 EMD66433.1 - 4.2e-06 26.8 0.1 1e-05 25.6 0.1 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EMD66433.1 - 0.0022 18.2 0.1 0.0058 16.9 0.1 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain Integrase_H2C2 PF17921.1 EMD66435.1 - 0.0001 22.3 0.1 0.00012 22.2 0.1 1.1 1 0 0 1 1 1 1 Integrase zinc binding domain HrpB7 PF09486.10 EMD66436.1 - 0.024 15.1 4.0 0.032 14.6 4.0 1.1 1 0 0 1 1 1 0 Bacterial type III secretion protein (HrpB7) YlqD PF11068.8 EMD66436.1 - 0.026 14.9 7.3 0.034 14.5 7.3 1.1 1 0 0 1 1 1 0 YlqD protein DUF3450 PF11932.8 EMD66436.1 - 0.35 10.1 9.1 0.46 9.7 9.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) PAXNEB PF05625.11 EMD66437.1 - 0.039 13.1 0.3 0.039 13.1 0.3 1.0 1 0 0 1 1 1 0 PAXNEB protein RVT_1 PF00078.27 EMD66439.1 - 0.0002 20.9 0.3 0.0002 20.9 0.3 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) TTRAP PF14203.6 EMD66439.1 - 0.033 14.2 0.1 0.047 13.7 0.1 1.3 1 0 0 1 1 1 0 Putative tranposon-transfer assisting protein EABR PF12180.8 EMD66439.1 - 0.069 12.8 2.1 0.74 9.5 2.1 2.1 1 1 0 1 1 1 0 TSG101 and ALIX binding domain of CEP55 Ras PF00071.22 EMD66440.1 - 4.1e-52 176.0 0.1 1.3e-51 174.4 0.1 1.7 1 1 0 1 1 1 1 Ras family Roc PF08477.13 EMD66440.1 - 8.1e-19 68.0 0.0 8.8e-17 61.4 0.0 2.2 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMD66440.1 - 0.00022 20.7 0.0 0.00075 19.0 0.0 1.8 1 1 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EMD66440.1 - 0.019 14.9 0.0 6.6 6.6 0.0 2.3 2 0 0 2 2 2 0 RsgA GTPase GTP_EFTU PF00009.27 EMD66440.1 - 0.023 14.2 0.1 4.7 6.7 0.0 2.8 2 1 1 3 3 3 0 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 EMD66440.1 - 0.025 14.1 0.1 0.36 10.3 0.0 2.3 2 1 1 3 3 3 0 Ferrous iron transport protein B Septin PF00735.18 EMD66440.1 - 0.059 12.6 0.0 0.095 12.0 0.0 1.3 1 0 0 1 1 1 0 Septin MMR_HSR1 PF01926.23 EMD66440.1 - 0.069 13.2 0.0 0.096 12.8 0.0 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_16 PF13191.6 EMD66440.1 - 0.073 13.5 0.0 0.11 12.9 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain AAA_25 PF13481.6 EMD66440.1 - 0.18 11.4 0.0 0.34 10.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain K-cyclin_vir_C PF09080.10 EMD66442.1 - 0.19 12.2 1.3 0.42 11.1 1.3 1.6 1 0 0 1 1 1 0 K cyclin, C terminal AMP-binding PF00501.28 EMD66443.1 - 2.2e-78 263.8 0.0 2.8e-78 263.4 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme ACAS_N PF16177.5 EMD66443.1 - 2.4e-15 56.2 2.5 7.5e-15 54.6 2.5 1.9 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus AMP-binding_C PF13193.6 EMD66443.1 - 2.1e-14 54.2 0.0 4.6e-14 53.2 0.0 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain HAD_2 PF13419.6 EMD66444.1 - 4.7e-09 36.6 0.0 2.4e-08 34.3 0.0 2.0 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EMD66444.1 - 2.3e-07 30.8 0.1 7.6e-07 29.1 0.0 1.9 1 1 1 2 2 2 1 HAD-hyrolase-like Hydrolase PF00702.26 EMD66444.1 - 2.4e-07 31.3 0.0 3.3e-07 30.8 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase CENP-T_C PF15511.6 EMD66445.1 - 8e-09 35.6 0.1 9.7e-09 35.3 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold Histone PF00125.24 EMD66445.1 - 2.4e-05 24.7 0.1 2.8e-05 24.5 0.1 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TAF PF02969.17 EMD66445.1 - 7.2e-05 22.9 0.1 0.0001 22.4 0.1 1.3 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CBFD_NFYB_HMF PF00808.23 EMD66445.1 - 0.0002 21.6 0.1 0.00035 20.8 0.0 1.5 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-S PF15630.6 EMD66445.1 - 0.0004 20.7 0.1 0.00056 20.2 0.1 1.4 1 1 0 1 1 1 1 CENP-S protein TFIID-31kDa PF02291.15 EMD66445.1 - 0.0085 16.2 0.0 0.01 15.9 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 EMD66445.1 - 0.031 14.3 0.0 0.037 14.0 0.0 1.3 1 0 0 1 1 1 0 Bromodomain associated UPF0137 PF03677.13 EMD66445.1 - 0.052 13.3 0.2 0.064 13.0 0.2 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0137) HIGH_NTase1_ass PF16581.5 EMD66445.1 - 0.11 12.5 0.0 0.12 12.3 0.0 1.1 1 0 0 1 1 1 0 Cytidyltransferase-related C-terminal region Histone PF00125.24 EMD66446.1 - 4e-52 176.0 2.5 4.5e-52 175.9 2.5 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.6 EMD66446.1 - 6e-06 26.5 0.0 9e-06 26.0 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein PAF PF15715.5 EMD66446.1 - 4e-05 24.2 1.2 4.7e-05 24.0 1.2 1.2 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CENP-T_C PF15511.6 EMD66446.1 - 4.3e-05 23.6 0.3 7.9e-05 22.7 0.1 1.6 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold CBFD_NFYB_HMF PF00808.23 EMD66446.1 - 0.0038 17.5 0.4 0.0065 16.7 0.0 1.5 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 EMD66446.1 - 0.028 14.5 0.2 0.048 13.7 0.0 1.5 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit AhpC-TSA PF00578.21 EMD66447.1 - 7.6e-05 22.6 0.0 0.00013 21.9 0.0 1.4 1 1 0 1 1 1 1 AhpC/TSA family AhpC-TSA_2 PF13911.6 EMD66447.1 - 0.00019 21.5 0.0 0.0003 20.9 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme Exo5 PF09810.9 EMD66448.1 - 5.2e-129 430.9 0.0 1e-126 423.3 0.0 2.1 1 1 0 1 1 1 1 Exonuclease V - a 5' deoxyribonuclease PDDEXK_1 PF12705.7 EMD66448.1 - 2.1e-05 24.5 0.0 0.0031 17.5 0.0 2.4 2 0 0 2 2 2 2 PD-(D/E)XK nuclease superfamily DUF1985 PF09331.11 EMD66448.1 - 0.18 11.8 0.0 0.31 11.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1985) Glyco_hydro_43 PF04616.14 EMD66449.1 - 5.1e-36 124.5 13.9 6.1e-36 124.2 13.9 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 RED_N PF07808.13 EMD66450.1 - 1.3e-06 28.2 7.3 7.4e-06 25.7 7.4 2.3 1 1 0 1 1 1 1 RED-like protein N-terminal region GvpG PF05120.12 EMD66450.1 - 0.012 15.6 0.2 0.043 13.8 0.2 2.0 1 0 0 1 1 1 0 Gas vesicle protein G PALP PF00291.25 EMD66451.1 - 2.1e-56 191.5 1.0 2.5e-56 191.3 1.0 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme DNA_photolyase PF00875.18 EMD66451.1 - 0.028 14.4 0.0 0.4 10.7 0.0 2.5 2 0 0 2 2 2 0 DNA photolyase EI24 PF07264.11 EMD66452.1 - 3.4e-08 33.9 15.3 5.7e-08 33.2 15.3 1.3 1 0 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) Asp PF00026.23 EMD66453.1 - 1.5e-108 363.0 0.0 1.7e-108 362.8 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EMD66453.1 - 1.5e-15 57.9 2.0 2.3e-13 50.7 2.0 2.7 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EMD66453.1 - 0.00027 21.5 0.0 0.57 10.9 0.0 3.0 2 1 0 2 2 2 2 Aspartyl protease TAXi_C PF14541.6 EMD66453.1 - 0.00053 19.8 0.0 0.0035 17.1 0.0 2.1 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal gag-asp_proteas PF13975.6 EMD66453.1 - 0.0015 19.0 0.0 2.2 8.9 0.0 2.7 2 0 0 2 2 2 2 gag-polyprotein putative aspartyl protease GRAM PF02893.20 EMD66454.1 - 1.1e-29 102.5 5.7 5.9e-19 68.0 0.2 3.5 3 0 0 3 3 3 3 GRAM domain Glyco_transf_28 PF03033.20 EMD66454.1 - 1.7e-27 96.2 0.0 3.4e-27 95.2 0.0 1.6 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain PH PF00169.29 EMD66454.1 - 1.1e-14 54.8 0.1 4.1e-14 53.0 0.1 2.0 1 0 0 1 1 1 1 PH domain UDPGT PF00201.18 EMD66454.1 - 7.3e-05 21.7 0.0 0.00014 20.8 0.0 1.4 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase PH_11 PF15413.6 EMD66454.1 - 0.00015 22.1 0.2 0.00068 20.0 0.2 2.3 1 0 0 1 1 1 1 Pleckstrin homology domain PH_3 PF14593.6 EMD66454.1 - 0.00026 21.0 0.0 0.00066 19.8 0.0 1.6 1 0 0 1 1 1 1 PH domain PH_2 PF08458.10 EMD66454.1 - 0.0099 16.2 0.1 0.034 14.5 0.1 1.9 1 0 0 1 1 1 1 Plant pleckstrin homology-like region NIF PF03031.18 EMD66455.1 - 1.1e-25 90.2 0.1 2.2e-25 89.2 0.1 1.5 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase BRCT PF00533.26 EMD66455.1 - 1.8e-09 37.8 0.0 4.6e-09 36.5 0.0 1.7 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 EMD66455.1 - 2.2e-06 27.5 0.0 4.9e-06 26.4 0.0 1.6 1 0 0 1 1 1 1 twin BRCT domain BRCT_2 PF16589.5 EMD66455.1 - 1.8e-05 25.0 0.0 6.9e-05 23.2 0.0 2.0 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 EMD66455.1 - 0.02 15.2 0.0 0.084 13.2 0.0 2.1 1 0 0 1 1 1 0 DNA ligase 3 BRCT domain Peptidase_S64 PF08192.11 EMD66455.1 - 0.43 9.0 5.2 0.89 8.0 5.2 1.4 1 0 0 1 1 1 0 Peptidase family S64 F-box-like PF12937.7 EMD66456.1 - 0.0021 17.9 0.0 0.0063 16.4 0.0 1.8 2 0 0 2 2 2 1 F-box-like zn-ribbon_14 PF16503.5 EMD66456.1 - 0.08 12.5 0.0 0.19 11.2 0.0 1.7 1 0 0 1 1 1 0 Zinc-ribbon Zn_clus PF00172.18 EMD66457.1 - 2.7e-08 33.8 9.0 5e-08 32.9 9.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EMD66457.1 - 0.00066 18.8 0.1 0.009 15.1 0.1 2.5 1 1 0 1 1 1 1 Fungal specific transcription factor domain Ribosomal_L11_N PF03946.14 EMD66458.1 - 1.1e-26 92.4 0.1 2.4e-26 91.4 0.1 1.5 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.19 EMD66458.1 - 2e-23 82.7 1.0 5.4e-23 81.3 1.0 1.8 1 1 0 1 1 1 1 Ribosomal protein L11, RNA binding domain SNF2_N PF00176.23 EMD66459.1 - 4.1e-57 193.5 0.0 6.8e-57 192.8 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Rad54_N PF08658.10 EMD66459.1 - 9.4e-56 188.8 0.4 9e-55 185.6 0.5 2.2 2 0 0 2 2 2 1 Rad54 N terminal Helicase_C PF00271.31 EMD66459.1 - 3.4e-15 56.3 0.0 1.1e-14 54.7 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EMD66459.1 - 2.2e-06 27.8 0.0 3.8e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HA2 PF04408.23 EMD66461.1 - 1.4e-17 63.9 0.0 1.4e-17 63.9 0.0 2.5 2 1 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EMD66461.1 - 1.8e-17 63.5 0.1 4.9e-17 62.1 0.0 1.8 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EMD66461.1 - 2.4e-13 50.4 0.0 1.6e-12 47.7 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Mannitol_dh PF01232.23 EMD66461.1 - 0.026 14.7 0.1 0.058 13.6 0.1 1.6 1 0 0 1 1 1 0 Mannitol dehydrogenase Rossmann domain ResIII PF04851.15 EMD66461.1 - 0.16 12.0 2.6 0.28 11.2 2.6 1.5 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit zf-DNL PF05180.12 EMD66462.1 - 1.7e-30 104.7 0.8 2.4e-30 104.3 0.8 1.2 1 0 0 1 1 1 1 DNL zinc finger HypA PF01155.19 EMD66462.1 - 0.0056 16.7 0.0 0.0072 16.3 0.0 1.2 1 0 0 1 1 1 1 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Zn_ribbon_SprT PF17283.2 EMD66462.1 - 0.65 10.0 6.3 5.4 7.0 0.3 2.3 2 0 0 2 2 2 0 SprT-like zinc ribbon domain Cullin PF00888.22 EMD66463.1 - 5.4e-206 685.9 5.7 7.4e-206 685.5 5.7 1.2 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 EMD66463.1 - 3.6e-25 87.8 5.7 5.3e-25 87.2 0.6 3.4 3 0 0 3 3 3 1 Cullin protein neddylation domain Rrf2 PF02082.20 EMD66463.1 - 0.14 12.5 0.1 0.52 10.7 0.0 1.9 2 0 0 2 2 2 0 Transcriptional regulator Spc29 PF17082.5 EMD66463.1 - 3.7 7.3 7.4 7.3 6.4 0.6 2.5 2 0 0 2 2 2 0 Spindle Pole Component 29 Sas10_Utp3 PF04000.15 EMD66464.1 - 7.9e-19 68.1 1.7 1.8e-18 66.9 1.7 1.6 1 0 0 1 1 1 1 Sas10/Utp3/C1D family Zn_clus PF00172.18 EMD66465.1 - 7.7e-09 35.5 8.4 7.7e-09 35.5 8.4 1.6 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF4055 PF13264.6 EMD66468.1 - 0.16 12.1 1.0 1.1 9.4 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4055) Telethonin PF09470.10 EMD66469.1 - 0.11 12.3 0.0 0.15 12.0 0.0 1.1 1 0 0 1 1 1 0 Telethonin protein PQ-loop PF04193.14 EMD66470.1 - 1e-22 79.7 1.3 1.8e-16 59.7 0.1 2.6 2 0 0 2 2 2 2 PQ loop repeat Evr1_Alr PF04777.13 EMD66471.1 - 7.2e-30 103.4 3.8 7.2e-30 103.4 3.8 1.7 2 0 0 2 2 2 1 Erv1 / Alr family Pkinase PF00069.25 EMD66472.1 - 1.3e-66 224.6 0.0 1.7e-66 224.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD66472.1 - 7.2e-32 110.7 0.0 9.4e-32 110.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EMD66472.1 - 0.00024 20.5 0.3 0.00038 19.9 0.3 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EMD66472.1 - 0.0023 16.9 0.4 0.0041 16.1 0.2 1.5 2 0 0 2 2 2 1 Haspin like kinase domain Kinase-like PF14531.6 EMD66472.1 - 0.0065 15.8 0.0 0.011 15.1 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EMD66472.1 - 0.018 15.0 0.1 0.038 13.9 0.1 1.5 1 1 0 1 1 1 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 EMD66472.1 - 0.033 13.3 0.1 0.049 12.7 0.1 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 DEAD PF00270.29 EMD66475.1 - 4.9e-49 166.5 0.0 1e-48 165.4 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EMD66475.1 - 1.4e-29 102.7 0.0 7.1e-28 97.2 0.0 2.8 3 0 0 3 3 3 1 Helicase conserved C-terminal domain UTP25 PF06862.12 EMD66475.1 - 0.00016 20.6 0.1 0.0016 17.3 0.0 2.2 2 1 1 3 3 3 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 CMS1 PF14617.6 EMD66475.1 - 0.058 12.7 0.0 0.058 12.7 0.0 3.0 2 1 1 3 3 3 0 U3-containing 90S pre-ribosomal complex subunit BNIP2 PF12496.8 EMD66475.1 - 3.7 8.0 8.8 12 6.4 8.6 1.9 1 1 0 1 1 1 0 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 TFIIIC_delta PF12657.7 EMD66476.1 - 4.8e-40 137.4 4.5 1.3e-39 136.1 0.3 2.8 3 0 0 3 3 3 1 Transcription factor IIIC subunit delta N-term zf-TFIIIC PF12660.7 EMD66476.1 - 5.5e-33 112.9 0.0 1.7e-32 111.4 0.0 1.8 1 1 0 1 1 1 1 Putative zinc-finger of transcription factor IIIC complex CENP-B_dimeris PF09026.10 EMD66476.1 - 0.17 12.3 8.8 0.47 10.9 8.8 1.7 1 0 0 1 1 1 0 Centromere protein B dimerisation domain PPP4R2 PF09184.11 EMD66476.1 - 9.5 5.7 8.3 20 4.6 8.3 1.5 1 0 0 1 1 1 0 PPP4R2 Ctr PF04145.15 EMD66477.1 - 3.1e-39 134.9 0.4 3.7e-39 134.7 0.4 1.1 1 0 0 1 1 1 1 Ctr copper transporter family PAP2 PF01569.21 EMD66477.1 - 0.0041 16.9 0.3 0.0075 16.0 0.3 1.3 1 1 0 1 1 1 1 PAP2 superfamily DUF4407 PF14362.6 EMD66477.1 - 0.044 13.2 1.1 0.066 12.6 1.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF2530 PF10745.9 EMD66477.1 - 0.051 13.8 2.7 6.4 7.1 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2530) Oxidored_q3 PF00499.20 EMD66477.1 - 0.074 12.8 4.8 0.52 10.0 3.4 2.0 2 0 0 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 DJ-1_PfpI PF01965.24 EMD66478.1 - 9.5e-13 48.3 0.0 1.3e-12 47.8 0.0 1.1 1 0 0 1 1 1 1 DJ-1/PfpI family GATase PF00117.28 EMD66478.1 - 0.0079 16.0 0.0 0.0098 15.7 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I DIT1_PvcA PF05141.12 EMD66479.1 - 3e-88 295.9 0.0 4.2e-88 295.4 0.0 1.2 1 0 0 1 1 1 1 Pyoverdine/dityrosine biosynthesis protein NUSAP PF16006.5 EMD66479.1 - 0.23 11.2 0.3 4.5 6.9 0.0 2.2 1 1 1 2 2 2 0 Nucleolar and spindle-associated protein p450 PF00067.22 EMD66480.1 - 4.3e-61 207.1 0.0 5.2e-61 206.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 HRG PF16954.5 EMD66480.1 - 0.21 12.0 0.7 0.45 11.0 0.7 1.5 1 0 0 1 1 1 0 Haem-transporter, endosomal/lysosomal, haem-responsive gene DUF5353 PF17304.2 EMD66480.1 - 0.3 10.8 2.2 0.43 10.4 0.1 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5353) MFS_1 PF07690.16 EMD66481.1 - 2.3e-38 132.0 37.0 2.3e-38 132.0 37.0 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 EMD66481.1 - 9.1 4.4 13.7 0.51 8.6 5.8 2.7 2 1 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family DSBA PF01323.20 EMD66482.1 - 4.1e-37 127.9 0.0 4.6e-37 127.7 0.0 1.0 1 0 0 1 1 1 1 DSBA-like thioredoxin domain Thioredoxin_4 PF13462.6 EMD66482.1 - 0.00011 22.4 0.9 0.00026 21.2 0.0 1.9 2 1 0 2 2 2 1 Thioredoxin Thioredoxin_5 PF13743.6 EMD66482.1 - 0.00021 21.0 0.1 0.00056 19.6 0.0 1.6 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_2 PF13098.6 EMD66482.1 - 0.01 16.3 0.3 0.33 11.4 0.1 2.1 2 0 0 2 2 2 0 Thioredoxin-like domain Mrr_N PF14338.6 EMD66482.1 - 0.059 13.5 0.1 0.13 12.4 0.1 1.6 1 0 0 1 1 1 0 Mrr N-terminal domain Cellulase PF00150.18 EMD66483.1 - 7.1e-07 28.9 4.6 5.2e-06 26.1 4.6 2.2 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Ribosomal_S18 PF01084.20 EMD66484.1 - 2.2e-16 59.8 0.8 4.6e-16 58.8 0.1 1.9 2 0 0 2 2 2 1 Ribosomal protein S18 PPR_2 PF13041.6 EMD66485.1 - 1.3e-07 31.7 3.5 0.79 10.0 0.0 6.9 6 1 0 6 6 6 1 PPR repeat family PPR PF01535.20 EMD66485.1 - 6.5e-05 22.9 4.2 4.1 7.9 0.1 6.0 7 0 0 7 7 7 2 PPR repeat PPR_3 PF13812.6 EMD66485.1 - 0.0042 17.1 0.0 47 4.2 0.0 4.9 5 0 0 5 5 5 0 Pentatricopeptide repeat domain PPR_long PF17177.4 EMD66485.1 - 0.069 12.5 0.0 3.5 6.9 0.0 3.1 3 0 0 3 3 3 0 Pentacotripeptide-repeat region of PRORP TPR_15 PF13429.6 EMD66485.1 - 0.091 12.0 0.8 2.9 7.0 0.1 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat BTAD PF03704.17 EMD66485.1 - 0.74 10.2 5.5 0.4 11.1 0.1 3.0 4 0 0 4 4 4 0 Bacterial transcriptional activator domain Kelch_5 PF13854.6 EMD66486.1 - 2.6e-14 52.8 4.9 3.6e-07 30.0 0.0 4.9 4 0 0 4 4 4 3 Kelch motif Kelch_1 PF01344.25 EMD66486.1 - 4.7e-08 32.5 4.9 0.0065 16.0 0.1 3.9 3 0 0 3 3 3 3 Kelch motif Kelch_6 PF13964.6 EMD66486.1 - 6.2e-08 32.7 9.5 0.05 13.9 0.2 5.7 5 0 0 5 5 5 3 Kelch motif Kelch_4 PF13418.6 EMD66486.1 - 6e-06 26.2 8.6 0.68 10.0 0.2 5.0 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_3 PF13415.6 EMD66486.1 - 0.00033 20.9 20.7 0.054 13.8 0.2 6.1 7 1 0 7 7 7 3 Galactose oxidase, central domain Kelch_2 PF07646.15 EMD66486.1 - 0.19 11.8 8.8 0.21 11.6 0.2 4.4 6 0 0 6 6 6 0 Kelch motif Myb_DNA-binding PF00249.31 EMD66487.1 - 2.7e-19 69.1 4.4 1.9e-12 47.2 0.2 3.9 3 0 0 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EMD66487.1 - 7.4e-11 42.1 8.9 2.9e-10 40.3 2.0 3.5 2 1 1 3 3 3 2 Myb-like DNA-binding domain Inh PF02974.14 EMD66488.1 - 0.048 13.7 0.2 0.097 12.7 0.2 1.5 1 0 0 1 1 1 0 Protease inhibitor Inh Mito_carr PF00153.27 EMD66489.1 - 3.4e-59 196.8 6.8 3.6e-20 71.7 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein ADH_zinc_N PF00107.26 EMD66490.1 - 6.4e-21 74.7 0.1 1.2e-20 73.8 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EMD66490.1 - 8.3e-16 59.3 0.0 1.3e-15 58.6 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EMD66490.1 - 6.8e-07 29.2 0.0 3.1e-05 23.8 0.0 2.5 1 1 1 2 2 2 2 Alcohol dehydrogenase GroES-like domain Glu_dehyd_C PF16912.5 EMD66490.1 - 0.0025 17.3 0.0 0.0033 16.9 0.0 1.2 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus F_bP_aldolase PF01116.20 EMD66490.1 - 0.047 13.2 0.6 0.097 12.1 0.1 1.6 1 1 1 2 2 2 0 Fructose-bisphosphate aldolase class-II DapB_N PF01113.20 EMD66490.1 - 0.1 12.7 0.2 0.28 11.3 0.2 1.5 1 1 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Rep_fac-A_C PF08646.10 EMD66491.1 - 1e-54 184.3 2.4 3.5e-51 172.8 1.4 2.4 2 0 0 2 2 2 2 Replication factor-A C terminal domain REPA_OB_2 PF16900.5 EMD66491.1 - 9.6e-37 124.9 1.5 2e-36 123.8 1.0 1.8 2 0 0 2 2 2 1 Replication protein A OB domain Rep-A_N PF04057.12 EMD66491.1 - 5.7e-21 74.4 0.3 5.7e-21 74.4 0.3 2.0 3 0 0 3 3 3 1 Replication factor-A protein 1, N-terminal domain tRNA_anti-codon PF01336.25 EMD66491.1 - 8.8e-13 48.0 0.1 1.3e-07 31.4 0.0 3.7 4 0 0 4 4 4 2 OB-fold nucleic acid binding domain DUF4503 PF14951.6 EMD66491.1 - 0.0097 14.4 0.1 0.015 13.8 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4503) CDC24_OB3 PF17244.2 EMD66491.1 - 0.051 13.3 0.2 2.1 8.0 0.0 2.8 3 0 0 3 3 3 0 Cell division control protein 24, OB domain 3 DLH PF01738.18 EMD66492.1 - 1.3e-16 60.8 0.3 1.8e-14 53.8 0.3 2.3 1 1 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_3 PF07859.13 EMD66492.1 - 0.032 14.1 0.1 0.072 12.9 0.0 1.6 2 0 0 2 2 2 0 alpha/beta hydrolase fold SnoaL_2 PF12680.7 EMD66493.1 - 2.1e-06 28.3 0.1 3.3e-06 27.7 0.1 1.3 1 0 0 1 1 1 1 SnoaL-like domain SnoaL PF07366.12 EMD66493.1 - 6.6e-06 25.9 0.1 1e-05 25.4 0.1 1.3 1 0 0 1 1 1 1 SnoaL-like polyketide cyclase Aspzincin_M35 PF14521.6 EMD66494.1 - 6.8e-05 23.5 0.6 0.00038 21.0 0.6 2.1 1 1 0 1 1 1 1 Lysine-specific metallo-endopeptidase Foamy_virus_ENV PF03408.14 EMD66495.1 - 0.024 12.5 0.0 0.029 12.3 0.0 1.1 1 0 0 1 1 1 0 Foamy virus envelope protein AhpC-TSA PF00578.21 EMD66496.1 - 5.7e-31 107.0 0.0 7.6e-31 106.6 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EMD66496.1 - 8.8e-17 61.2 0.0 1.1e-16 60.8 0.0 1.2 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 EMD66496.1 - 2.2e-15 56.2 0.2 4e-15 55.4 0.2 1.4 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin PCI PF01399.27 EMD66497.1 - 0.00093 19.7 0.1 0.037 14.6 0.0 3.0 3 0 0 3 3 3 1 PCI domain ANAPC3 PF12895.7 EMD66497.1 - 0.0066 16.6 0.6 0.016 15.4 0.6 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 Na_K-ATPase PF00287.18 EMD66497.1 - 0.049 12.8 0.0 0.086 12.0 0.0 1.3 1 0 0 1 1 1 0 Sodium / potassium ATPase beta chain Pyr_redox_3 PF13738.6 EMD66498.1 - 1.4e-14 54.0 0.0 1.3e-12 47.6 0.1 2.6 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 EMD66498.1 - 3.8e-14 52.0 0.0 5.2e-13 48.3 0.0 2.5 1 1 0 1 1 1 1 Flavin-binding monooxygenase-like K_oxygenase PF13434.6 EMD66498.1 - 7e-11 41.9 0.0 3.9e-08 32.8 0.0 2.9 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.14 EMD66498.1 - 3.4e-10 39.7 0.0 9.9e-09 34.8 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EMD66498.1 - 2.7e-06 27.5 0.6 1.5e-05 25.1 0.1 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Shikimate_DH PF01488.20 EMD66498.1 - 0.0001 22.4 0.0 1.6 8.8 0.0 3.1 3 0 0 3 3 3 2 Shikimate / quinate 5-dehydrogenase Pyr_redox PF00070.27 EMD66498.1 - 0.00011 22.7 0.4 0.43 11.2 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EMD66498.1 - 0.00016 21.7 0.2 0.22 11.5 0.1 3.7 4 0 0 4 4 4 1 FAD-NAD(P)-binding AlaDh_PNT_C PF01262.21 EMD66498.1 - 0.0086 15.4 0.2 0.84 8.9 0.0 2.2 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain Amino_oxidase PF01593.24 EMD66498.1 - 0.081 12.2 0.0 3.4 6.8 0.0 2.1 1 1 1 2 2 2 0 Flavin containing amine oxidoreductase FAD_binding_2 PF00890.24 EMD66498.1 - 0.088 11.9 0.3 0.15 11.1 0.3 1.3 1 0 0 1 1 1 0 FAD binding domain 2-Hacid_dh_C PF02826.19 EMD66498.1 - 0.14 11.5 0.0 6 6.2 0.0 2.3 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain FAD_binding_3 PF01494.19 EMD66498.1 - 0.15 11.3 0.0 0.26 10.5 0.0 1.4 1 0 0 1 1 1 0 FAD binding domain DAO PF01266.24 EMD66498.1 - 2.3 7.7 7.0 0.23 11.0 1.4 2.1 3 1 0 3 3 3 0 FAD dependent oxidoreductase GIDA PF01134.22 EMD66498.1 - 9.5 5.2 5.3 1.1 8.2 0.3 2.0 3 0 0 3 3 3 0 Glucose inhibited division protein A Rhodanese PF00581.20 EMD66500.1 - 4.6e-13 49.6 0.0 9.1e-13 48.7 0.0 1.5 1 0 0 1 1 1 1 Rhodanese-like domain SLD5_C PF16922.5 EMD66501.1 - 5.7e-18 64.9 0.6 9.8e-18 64.1 0.6 1.4 1 0 0 1 1 1 1 DNA replication complex GINS protein SLD5 C-terminus Sld5 PF05916.11 EMD66501.1 - 0.00016 22.1 0.1 0.00042 20.8 0.1 1.7 1 1 0 1 1 1 1 GINS complex protein E1-E2_ATPase PF00122.20 EMD66502.1 - 3.1e-45 153.9 0.0 3.1e-45 153.9 0.0 2.0 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 EMD66502.1 - 3.1e-42 144.4 0.3 6.6e-42 143.3 0.3 1.6 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 EMD66502.1 - 2.8e-20 73.5 6.0 2.5e-19 70.4 6.0 2.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EMD66502.1 - 2e-18 65.8 0.1 3.9e-18 64.9 0.1 1.5 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 EMD66502.1 - 8.6e-14 51.4 0.0 1.7e-13 50.5 0.0 1.4 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EMD66502.1 - 0.00044 20.1 2.3 0.0007 19.4 1.2 1.8 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF1996 PF09362.10 EMD66503.1 - 3.3e-74 249.8 0.1 4.2e-74 249.5 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1996) Rad21_Rec8_N PF04825.13 EMD66504.1 - 2.2e-31 108.3 0.0 4.4e-31 107.3 0.0 1.5 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein Rad21_Rec8 PF04824.16 EMD66504.1 - 6.2e-08 31.8 0.0 1.4e-07 30.7 0.0 1.5 1 0 0 1 1 1 1 Conserved region of Rad21 / Rec8 like protein Fungal_trans PF04082.18 EMD66505.1 - 5.5e-20 71.5 0.2 8.6e-20 70.9 0.2 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD66505.1 - 2.5e-10 40.3 8.6 4.1e-10 39.6 8.6 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PrpF PF04303.13 EMD66506.1 - 3.5e-100 335.6 0.9 7.6e-92 308.1 1.2 2.0 2 0 0 2 2 2 2 PrpF protein Sua5_yciO_yrdC PF01300.18 EMD66507.1 - 7.6e-53 178.7 0.0 1.3e-52 177.9 0.0 1.4 1 0 0 1 1 1 1 Telomere recombination SUA5 PF03481.13 EMD66507.1 - 1.2e-33 116.6 0.0 2.3e-33 115.6 0.0 1.4 1 0 0 1 1 1 1 Putative GTP-binding controlling metal-binding Glyco_hydro_cc PF11790.8 EMD66509.1 - 3.4e-58 197.1 0.6 4.6e-58 196.6 0.6 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core Glyco_hydro_53 PF07745.13 EMD66509.1 - 0.01 14.9 0.0 0.015 14.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 53 SSXT PF05030.12 EMD66510.1 - 1e-06 28.2 0.7 1.3e-05 24.7 0.7 2.4 1 1 0 1 1 1 1 SSXT protein (N-terminal region) FtsJ PF01728.19 EMD66511.1 - 1.8e-51 174.8 0.0 2.4e-51 174.4 0.0 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_23 PF13489.6 EMD66511.1 - 0.024 14.5 0.0 0.15 11.9 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_31 PF13847.6 EMD66511.1 - 0.065 13.0 0.0 3.2 7.5 0.0 2.3 2 0 0 2 2 2 0 Methyltransferase domain Mito_carr PF00153.27 EMD66512.1 - 1.6e-71 236.3 4.0 7.1e-24 83.5 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 EMD66512.1 - 0.0006 19.0 1.1 0.12 11.5 0.1 3.1 4 1 1 5 5 5 2 Gammaproteobacterial serine protease GAD-like PF08887.11 EMD66512.1 - 0.0029 17.4 0.1 0.012 15.4 0.0 2.0 2 1 1 3 3 3 1 GAD-like domain 2Fe-2S_thioredx PF01257.19 EMD66513.1 - 6.9e-62 207.6 0.6 8.4e-62 207.3 0.6 1.1 1 0 0 1 1 1 1 Thioredoxin-like [2Fe-2S] ferredoxin PIG-L PF02585.17 EMD66515.1 - 0.038 14.6 0.0 0.11 13.1 0.0 1.8 1 1 0 1 1 1 0 GlcNAc-PI de-N-acetylase DUF3824 PF12868.7 EMD66516.1 - 2.6e-39 135.3 35.2 2.6e-39 135.3 35.2 11.1 6 3 5 11 11 11 3 Domain of unknwon function (DUF3824) ABA_WDS PF02496.16 EMD66516.1 - 0.012 16.1 24.0 0.72 10.4 1.4 5.1 4 0 0 4 4 4 0 ABA/WDS induced protein DUF533 PF04391.12 EMD66516.1 - 0.046 13.3 15.6 0.89 9.1 1.1 3.7 3 1 1 4 4 4 0 Protein of unknown function (DUF533) CorA PF01544.18 EMD66517.1 - 2.4e-43 148.5 2.6 4.4e-42 144.4 2.6 2.1 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein MFS_1 PF07690.16 EMD66518.1 - 2e-29 102.6 33.7 2e-29 102.6 33.7 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily Acyltransferase PF01553.21 EMD66521.1 - 1.8e-27 95.6 0.0 2.9e-27 94.9 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase Acyltransf_C PF16076.5 EMD66521.1 - 2.3e-13 50.0 0.2 6.1e-13 48.7 0.2 1.7 1 0 0 1 1 1 1 Acyltransferase C-terminus Elong-fact-P_C PF09285.11 EMD66521.1 - 6.8 6.5 6.3 3.6 7.4 0.6 2.9 3 0 0 3 3 3 0 Elongation factor P, C-terminal Hep_59 PF07052.11 EMD66522.1 - 2.8e-07 31.2 0.0 2.8e-07 31.2 0.0 2.8 3 1 0 3 3 3 1 Hepatocellular carcinoma-associated antigen 59 NifU_N PF01592.16 EMD66523.1 - 5.7e-54 181.7 0.0 7.2e-54 181.4 0.0 1.1 1 0 0 1 1 1 1 NifU-like N terminal domain TSCPD PF12637.7 EMD66523.1 - 0.056 13.7 0.0 0.099 12.9 0.0 1.3 1 0 0 1 1 1 0 TSCPD domain DNA_pol_phi PF04931.13 EMD66524.1 - 1.1e-220 734.8 26.5 1.5e-220 734.3 26.5 1.2 1 0 0 1 1 1 1 DNA polymerase phi UCH PF00443.29 EMD66524.1 - 7.7e-38 130.4 0.1 1.5e-34 119.7 0.0 3.1 3 0 0 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase Med4 PF10018.9 EMD66524.1 - 2.5e-36 125.2 1.4 2.5e-36 125.2 1.4 2.2 2 0 0 2 2 2 1 Vitamin-D-receptor interacting Mediator subunit 4 zf-UBP PF02148.19 EMD66524.1 - 3.6e-25 88.1 6.7 8.4e-20 70.9 0.9 2.8 2 0 0 2 2 2 2 Zn-finger in ubiquitin-hydrolases and other protein zf-UBP_var PF17807.1 EMD66524.1 - 9.3e-24 83.0 1.8 1e-22 79.6 0.1 2.6 2 0 0 2 2 2 1 Variant UBP zinc finger UBA PF00627.31 EMD66524.1 - 7.7e-21 73.6 0.1 1.2e-10 41.0 0.1 2.8 2 0 0 2 2 2 2 UBA/TS-N domain UCH_1 PF13423.6 EMD66524.1 - 2.6e-18 66.7 4.7 5e-17 62.5 0.0 4.0 3 1 0 3 3 3 1 Ubiquitin carboxyl-terminal hydrolase SDA1 PF05285.12 EMD66524.1 - 0.002 17.6 20.4 0.002 17.6 20.4 3.0 3 0 0 3 3 3 1 SDA1 UBA_4 PF14555.6 EMD66524.1 - 0.033 14.0 0.0 0.086 12.7 0.0 1.7 1 0 0 1 1 1 0 UBA-like domain TFIIF_alpha PF05793.12 EMD66524.1 - 4.8 5.6 25.0 14 4.1 25.0 1.7 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) EF-hand_7 PF13499.6 EMD66525.1 - 5.2e-24 84.5 6.7 2e-15 57.0 0.5 3.2 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.32 EMD66525.1 - 1.1e-23 80.9 13.0 4.8e-08 32.0 0.1 4.9 5 1 1 6 6 6 3 EF hand EF-hand_6 PF13405.6 EMD66525.1 - 7.4e-23 78.5 4.9 4.3e-06 26.2 0.1 5.3 4 1 1 5 5 5 4 EF-hand domain EF-hand_5 PF13202.6 EMD66525.1 - 1.7e-17 62.0 11.6 3.2e-05 23.2 0.0 4.9 5 0 0 5 5 5 3 EF hand EF-hand_8 PF13833.6 EMD66525.1 - 2.3e-13 49.8 11.2 2.9e-05 23.8 0.9 3.8 2 2 1 3 3 3 3 EF-hand domain pair EF-hand_4 PF12763.7 EMD66525.1 - 3.6e-08 33.3 6.1 0.002 18.0 0.1 3.9 1 1 3 4 4 4 3 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 EMD66525.1 - 0.00078 19.7 0.5 0.022 15.1 0.1 2.9 2 1 1 3 3 3 1 EF-hand domain SPARC_Ca_bdg PF10591.9 EMD66525.1 - 0.00091 19.5 2.9 1 9.7 0.2 3.2 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region DUF1679 PF07914.11 EMD66525.1 - 0.058 12.2 0.5 2.7 6.7 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1679) EF-hand_10 PF14788.6 EMD66525.1 - 0.31 11.0 2.9 2.5 8.0 0.0 3.4 3 1 0 3 3 3 0 EF hand EMP70 PF02990.16 EMD66526.1 - 5.4e-207 688.6 2.1 6.7e-207 688.2 2.1 1.1 1 0 0 1 1 1 1 Endomembrane protein 70 DUF3920 PF13058.6 EMD66526.1 - 0.12 12.6 0.0 0.21 11.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3920) SUR7 PF06687.12 EMD66527.1 - 0.013 15.1 3.7 0.013 15.1 3.7 3.4 1 1 2 3 3 3 0 SUR7/PalI family DUF2448 PF10476.9 EMD66527.1 - 0.34 10.8 6.7 0.74 9.6 6.7 1.5 1 0 0 1 1 1 0 Protein of unknown function C-terminus (DUF2448) MBOAT PF03062.19 EMD66528.1 - 3.3e-40 138.5 17.7 3.3e-40 138.5 17.7 2.8 2 1 0 2 2 2 1 MBOAT, membrane-bound O-acyltransferase family MBOAT_2 PF13813.6 EMD66528.1 - 0.0024 18.1 5.2 0.0078 16.5 5.2 1.8 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family AC_N PF16214.5 EMD66528.1 - 0.2 10.8 1.9 0.34 10.0 1.9 1.3 1 0 0 1 1 1 0 Adenylyl cyclase N-terminal extracellular and transmembrane region 3HCDH_N PF02737.18 EMD66529.1 - 8e-35 120.3 0.0 1.2e-34 119.7 0.0 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 EMD66529.1 - 1.2e-12 48.3 0.0 2.8e-12 47.1 0.0 1.6 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain Pyr_redox_2 PF07992.14 EMD66529.1 - 0.0088 15.3 0.2 0.02 14.1 0.0 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EMD66529.1 - 0.054 14.1 0.1 0.22 12.1 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase AMP-binding PF00501.28 EMD66530.1 - 2.2e-82 276.9 0.0 2.9e-82 276.6 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EMD66530.1 - 8.9e-15 55.4 0.3 2.3e-14 54.1 0.2 1.8 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain Rho_RNA_bind PF07497.12 EMD66530.1 - 0.0083 16.0 0.0 0.049 13.5 0.0 2.3 3 0 0 3 3 3 1 Rho termination factor, RNA-binding domain Metallophos PF00149.28 EMD66531.1 - 3.6e-12 47.2 1.1 6e-12 46.5 1.1 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase 5_nucleotid_C PF02872.18 EMD66531.1 - 0.029 14.6 0.0 0.064 13.5 0.0 1.6 1 0 0 1 1 1 0 5'-nucleotidase, C-terminal domain DUF2721 PF11026.8 EMD66532.1 - 0.19 11.6 2.1 0.14 12.1 0.4 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) WD40 PF00400.32 EMD66533.1 - 6.8e-17 61.5 10.4 3.6e-05 24.4 0.0 8.0 8 0 0 8 8 8 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD66533.1 - 3.4e-06 27.3 0.0 0.4 11.0 0.0 4.6 3 2 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EMD66533.1 - 0.00079 18.5 0.1 2.7 6.8 0.0 3.3 1 1 2 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF3060 PF11259.8 EMD66533.1 - 0.037 13.7 0.2 0.29 10.9 0.0 2.4 2 1 1 3 3 3 0 Protein of unknown function (DUF3060) bZIP_1 PF00170.21 EMD66534.1 - 2.1e-14 53.3 9.5 3.9e-14 52.5 9.5 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EMD66534.1 - 1e-06 28.7 9.1 2.4e-06 27.5 9.1 1.6 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 EMD66534.1 - 0.0015 19.0 4.5 0.0015 19.0 4.5 2.0 3 0 0 3 3 3 1 bZIP Maf transcription factor Phlebovirus_NSM PF07246.11 EMD66534.1 - 0.01 15.2 0.2 0.018 14.5 0.2 1.3 1 0 0 1 1 1 0 Phlebovirus nonstructural protein NS-M DDE_3 PF13358.6 EMD66536.1 - 2.7e-07 30.5 0.3 0.00018 21.3 0.0 2.4 2 0 0 2 2 2 2 DDE superfamily endonuclease HTH_23 PF13384.6 EMD66536.1 - 0.028 14.2 0.1 0.09 12.6 0.0 1.9 2 0 0 2 2 2 0 Homeodomain-like domain ZapB PF06005.12 EMD66536.1 - 3.6 8.1 9.2 0.68 10.4 4.8 1.9 2 0 0 2 2 2 0 Cell division protein ZapB Fungal_trans PF04082.18 EMD66537.1 - 3.3e-14 52.5 0.1 5.8e-14 51.8 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain ArsP_1 PF03773.13 EMD66539.1 - 0.0029 16.8 0.3 0.0046 16.1 0.3 1.2 1 0 0 1 1 1 1 Predicted permease PGM_PMM_I PF02878.16 EMD66541.1 - 1.1e-40 138.5 0.0 2e-40 137.7 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.16 EMD66541.1 - 2.8e-23 82.5 0.0 7.2e-23 81.2 0.0 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.16 EMD66541.1 - 2.2e-13 50.4 0.0 4.3e-13 49.5 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_IV PF00408.20 EMD66541.1 - 2.4e-08 34.0 0.0 7.5e-08 32.4 0.0 1.8 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain Homeodomain PF00046.29 EMD66541.1 - 0.025 14.4 0.0 0.075 12.9 0.0 1.8 1 0 0 1 1 1 0 Homeodomain FA_desaturase PF00487.24 EMD66542.1 - 5.1e-22 78.9 30.0 8.3e-22 78.2 30.0 1.4 1 0 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.28 EMD66542.1 - 1.4e-09 38.0 0.0 4.1e-09 36.5 0.0 1.8 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Herpes_ICP4_C PF03585.14 EMD66543.1 - 0.005 15.6 0.0 0.005 15.6 0.0 1.0 1 0 0 1 1 1 1 Herpesvirus ICP4-like protein C-terminal region XFP_N PF09364.10 EMD66544.1 - 5.9e-171 568.2 0.0 7.8e-171 567.8 0.0 1.1 1 0 0 1 1 1 1 XFP N-terminal domain XFP PF03894.15 EMD66544.1 - 1.4e-83 278.9 0.0 2.6e-83 278.0 0.0 1.4 1 0 0 1 1 1 1 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase XFP_C PF09363.10 EMD66544.1 - 2.4e-82 275.3 0.0 4.1e-82 274.5 0.0 1.4 1 0 0 1 1 1 1 XFP C-terminal domain Kinesin PF00225.23 EMD66545.1 - 3.3e-83 279.4 0.2 4.8e-83 278.9 0.2 1.2 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EMD66545.1 - 4.6e-19 68.8 0.0 9e-19 67.9 0.0 1.5 1 0 0 1 1 1 1 Microtubule binding HHH_5 PF14520.6 EMD66545.1 - 0.00051 20.6 2.0 1 10.0 0.0 2.9 2 1 1 3 3 3 2 Helix-hairpin-helix domain HHH PF00633.23 EMD66545.1 - 0.0011 18.7 0.0 0.31 11.0 0.0 2.9 2 0 0 2 2 2 1 Helix-hairpin-helix motif AAA_22 PF13401.6 EMD66545.1 - 0.3 11.3 2.0 0.7 10.2 0.0 2.6 3 0 0 3 3 3 0 AAA domain ABC_tran_CTD PF16326.5 EMD66545.1 - 0.66 10.3 12.3 6.5 7.1 7.4 2.8 2 0 0 2 2 2 0 ABC transporter C-terminal domain ADIP PF11559.8 EMD66545.1 - 1.1 9.4 8.0 3.7 7.6 1.1 2.8 3 0 0 3 3 3 0 Afadin- and alpha -actinin-Binding Trimer_CC PF08954.11 EMD66545.1 - 2 8.0 10.7 0.092 12.3 0.5 3.3 3 0 0 3 3 3 0 Trimerisation motif zf-UBR PF02207.20 EMD66547.1 - 7.3e-14 51.7 5.3 7.3e-14 51.7 5.3 3.4 4 0 0 4 4 4 1 Putative zinc finger in N-recognin (UBR box) MCM PF00493.23 EMD66548.1 - 4.2e-103 343.3 0.0 6.2e-103 342.7 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EMD66548.1 - 3.1e-39 133.7 0.0 5.6e-39 132.9 0.0 1.4 1 0 0 1 1 1 1 MCM OB domain MCM2_N PF12619.8 EMD66548.1 - 2.6e-27 96.0 31.9 2.6e-27 96.0 31.9 2.0 2 0 0 2 2 2 1 Mini-chromosome maintenance protein 2 MCM_lid PF17855.1 EMD66548.1 - 2.3e-23 82.4 2.4 3.1e-23 82.0 0.9 2.1 2 0 0 2 2 2 1 MCM AAA-lid domain MCM_N PF14551.6 EMD66548.1 - 5.7e-16 59.0 0.0 1.4e-15 57.7 0.0 1.7 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 EMD66548.1 - 1.8e-08 34.1 0.0 2e-06 27.4 0.0 2.6 1 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EMD66548.1 - 2.8e-06 27.4 0.0 6.5e-06 26.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 EMD66548.1 - 0.0012 18.7 0.0 0.0043 16.9 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EMD66548.1 - 0.0028 17.4 0.1 0.018 14.8 0.1 2.0 1 1 0 1 1 1 1 Sigma-54 interaction domain FAM92 PF06730.11 EMD66548.1 - 0.027 13.9 0.8 0.058 12.8 0.8 1.5 1 0 0 1 1 1 0 FAM92 protein AAA_30 PF13604.6 EMD66548.1 - 0.055 13.2 0.2 0.13 12.0 0.2 1.5 1 0 0 1 1 1 0 AAA domain DUF3113 PF11310.8 EMD66548.1 - 0.074 13.0 0.0 0.31 11.0 0.0 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3113) Ribosomal_L7Ae PF01248.26 EMD66549.1 - 6.8e-25 86.6 0.0 7.7e-25 86.5 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Ribosomal_L16 PF00252.18 EMD66550.1 - 6.9e-45 152.3 0.1 1e-44 151.7 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e APG9 PF04109.16 EMD66551.1 - 3.3e-182 606.8 9.3 3.9e-182 606.5 9.3 1.0 1 0 0 1 1 1 1 Autophagy protein Apg9 COG6 PF06419.11 EMD66552.1 - 2e-215 716.8 12.2 2.2e-215 716.6 12.2 1.0 1 0 0 1 1 1 1 Conserved oligomeric complex COG6 DUF4054 PF13262.6 EMD66552.1 - 0.0091 16.0 0.0 0.025 14.6 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF4054) COG2 PF06148.11 EMD66552.1 - 0.025 14.7 2.2 0.16 12.1 0.5 3.0 3 0 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF948 PF06103.11 EMD66552.1 - 0.052 13.8 3.5 0.42 10.9 0.5 3.6 2 1 2 4 4 4 0 Bacterial protein of unknown function (DUF948) C166 PF17615.2 EMD66552.1 - 0.1 12.7 0.0 0.25 11.5 0.0 1.6 1 0 0 1 1 1 0 Family of unknown function Sec34 PF04136.15 EMD66552.1 - 0.11 12.4 2.1 0.28 11.1 0.3 2.6 2 0 0 2 2 2 0 Sec34-like family Laminin_II PF06009.12 EMD66552.1 - 0.28 11.2 6.2 5.1 7.1 0.2 3.6 2 2 1 3 3 3 0 Laminin Domain II Imm49 PF15575.6 EMD66552.1 - 0.36 10.6 5.0 0.13 12.0 0.2 2.6 3 0 0 3 3 3 0 Immunity protein 49 EspB_PE PF18625.1 EMD66552.1 - 0.51 10.8 3.7 1.5 9.4 0.0 3.2 3 0 0 3 3 3 0 ESX-1 secreted protein B PE domain HsbA PF12296.8 EMD66552.1 - 0.58 10.6 3.5 0.73 10.3 0.4 2.8 2 1 0 2 2 2 0 Hydrophobic surface binding protein A BolA PF01722.18 EMD66553.1 - 9.4e-17 61.1 0.0 2.9e-16 59.5 0.0 1.8 1 1 0 1 1 1 1 BolA-like protein NIF3 PF01784.18 EMD66554.1 - 1.6e-60 204.7 0.0 2.1e-60 204.4 0.0 1.1 1 0 0 1 1 1 1 NIF3 (NGG1p interacting factor 3) Band_7 PF01145.25 EMD66556.1 - 7.8e-15 55.3 0.1 7.8e-15 55.3 0.1 3.1 1 1 1 3 3 3 1 SPFH domain / Band 7 family Ndc1_Nup PF09531.10 EMD66559.1 - 1.7 7.3 7.9 3.9 6.0 7.9 1.6 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup BAF1_ABF1 PF04684.13 EMD66560.1 - 5 6.0 7.0 6.6 5.7 7.0 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor ERM PF00769.19 EMD66563.1 - 2.6 7.8 47.7 0.11 12.3 40.2 2.2 3 0 0 3 3 3 0 Ezrin/radixin/moesin family DDE_3 PF13358.6 EMD66564.1 - 3.5e-05 23.6 0.4 0.0046 16.7 0.0 2.2 2 0 0 2 2 2 2 DDE superfamily endonuclease Sigma70_r4_2 PF08281.12 EMD66564.1 - 0.00075 19.1 0.1 0.0015 18.1 0.1 1.6 1 0 0 1 1 1 1 Sigma-70, region 4 Catalase PF00199.19 EMD66565.1 - 8.2e-158 525.5 0.1 1.9e-157 524.3 0.1 1.6 1 1 0 1 1 1 1 Catalase Catalase_C PF18011.1 EMD66565.1 - 1.7e-44 151.2 0.9 2.7e-44 150.5 0.9 1.3 1 0 0 1 1 1 1 C-terminal domain found in long catalases Catalase-rel PF06628.12 EMD66565.1 - 5.3e-18 65.0 0.0 9.9e-18 64.1 0.0 1.5 1 0 0 1 1 1 1 Catalase-related immune-responsive Pil1 PF13805.6 EMD66566.1 - 9.4e-103 343.3 7.7 1.1e-102 343.0 7.7 1.1 1 0 0 1 1 1 1 Eisosome component PIL1 APG6_N PF17675.1 EMD66566.1 - 0.25 11.9 8.4 1.2 9.7 5.9 2.4 2 0 0 2 2 2 0 Apg6 coiled-coil region Seryl_tRNA_N PF02403.22 EMD66566.1 - 4.7 7.5 9.7 2 8.7 4.4 2.6 2 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain Sec23_trunk PF04811.15 EMD66567.1 - 6e-64 215.9 0.0 1.1e-63 215.0 0.0 1.5 2 0 0 2 2 2 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 EMD66567.1 - 2.8e-23 81.7 0.0 6.9e-23 80.4 0.0 1.7 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.12 EMD66567.1 - 4e-17 62.8 0.0 1e-16 61.5 0.0 1.7 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 EMD66567.1 - 5.3e-17 61.6 4.3 1e-16 60.7 4.3 1.5 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 EMD66567.1 - 2.7e-08 33.6 0.0 6e-08 32.5 0.0 1.6 1 0 0 1 1 1 1 Gelsolin repeat Vps36-NZF-N PF16988.5 EMD66567.1 - 0.021 14.2 0.5 0.052 12.9 0.1 1.8 2 0 0 2 2 2 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain zf-C2H2 PF00096.26 EMD66570.1 - 1.5e-05 25.2 12.0 0.0045 17.4 1.8 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMD66570.1 - 0.0003 21.1 3.8 0.0003 21.1 3.8 2.2 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMD66570.1 - 0.0013 19.4 11.3 0.081 13.8 2.9 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_5 PF13909.6 EMD66570.1 - 1.8 8.4 5.6 2.7 7.8 0.4 2.5 2 0 0 2 2 2 0 C2H2-type zinc-finger domain Drc1-Sld2 PF11719.8 EMD66571.1 - 6.9e-89 299.4 14.2 6.9e-89 299.4 14.2 2.0 2 0 0 2 2 2 1 DNA replication and checkpoint protein CSN8_PSD8_EIF3K PF10075.9 EMD66571.1 - 8.2e-20 71.3 0.0 2.8e-19 69.5 0.0 1.8 2 0 0 2 2 2 1 CSN8/PSMD8/EIF3K family SAC3_GANP PF03399.16 EMD66571.1 - 0.0028 17.1 0.0 0.0074 15.7 0.0 1.8 2 1 0 2 2 2 1 SAC3/GANP family Ribosomal_L29 PF00831.23 EMD66571.1 - 0.36 10.8 4.6 7.3 6.7 0.7 3.2 3 0 0 3 3 3 0 Ribosomal L29 protein Pyr_redox_2 PF07992.14 EMD66572.1 - 7.9e-68 228.8 7.1 8.9e-68 228.7 5.6 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 EMD66572.1 - 1.3e-39 134.8 0.3 4.4e-39 133.1 0.1 2.1 2 0 0 2 2 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain MA3 PF02847.17 EMD66572.1 - 8.9e-23 80.4 0.0 1.9e-22 79.4 0.0 1.6 1 0 0 1 1 1 1 MA3 domain Pyr_redox PF00070.27 EMD66572.1 - 1.1e-22 80.3 8.8 1.7e-19 70.2 1.5 3.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase MIF4G PF02854.19 EMD66572.1 - 6.3e-22 78.3 0.5 8.9e-21 74.5 0.1 2.3 2 0 0 2 2 2 1 MIF4G domain NAD_binding_8 PF13450.6 EMD66572.1 - 5.3e-10 39.4 5.0 4.3e-06 26.9 0.6 2.9 3 0 0 3 3 3 2 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 EMD66572.1 - 7.2e-09 35.2 7.7 8.5e-08 31.7 1.7 2.6 2 1 0 2 2 2 2 Glucose inhibited division protein A FAD_oxidored PF12831.7 EMD66572.1 - 2.9e-08 33.5 0.4 2.9e-08 33.5 0.4 2.6 2 1 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EMD66572.1 - 6.2e-07 29.0 7.1 4.1e-05 23.0 0.1 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 EMD66572.1 - 8.8e-07 28.4 5.8 0.0078 15.5 0.8 2.5 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_2 PF00890.24 EMD66572.1 - 3.2e-06 26.5 3.4 3.2e-06 26.5 3.4 2.7 2 1 0 2 2 2 1 FAD binding domain DAO PF01266.24 EMD66572.1 - 7.3e-05 22.5 14.1 0.0049 16.5 0.7 4.0 4 0 0 4 4 4 2 FAD dependent oxidoreductase HI0933_like PF03486.14 EMD66572.1 - 0.00037 19.3 2.8 0.00037 19.3 2.8 4.0 3 1 1 4 4 4 1 HI0933-like protein Thi4 PF01946.17 EMD66572.1 - 0.00042 19.6 2.2 0.00048 19.4 0.2 1.9 2 0 0 2 2 2 1 Thi4 family K_oxygenase PF13434.6 EMD66572.1 - 0.00057 19.1 1.2 0.45 9.6 0.1 2.9 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_7 PF13241.6 EMD66572.1 - 0.015 15.8 0.9 5.9 7.4 0.1 2.8 2 0 0 2 2 2 0 Putative NAD(P)-binding FAD_binding_3 PF01494.19 EMD66572.1 - 0.042 13.1 12.2 0.28 10.4 1.6 3.2 2 1 0 2 2 2 0 FAD binding domain 2-Hacid_dh_C PF02826.19 EMD66572.1 - 0.055 12.8 1.1 4.1 6.7 0.0 2.4 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Lycopene_cycl PF05834.12 EMD66572.1 - 0.11 11.5 4.8 0.14 11.1 0.1 2.7 3 0 0 3 3 3 0 Lycopene cyclase protein 3HCDH_N PF02737.18 EMD66572.1 - 0.76 9.6 9.9 0.045 13.6 0.9 2.6 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.14 EMD66572.1 - 1.6 8.3 4.9 2.4 7.7 0.2 2.4 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Trp_halogenase PF04820.14 EMD66572.1 - 1.9 7.3 7.1 0.25 10.2 1.6 2.0 2 0 0 2 2 2 0 Tryptophan halogenase SRP14 PF02290.15 EMD66573.1 - 2.4e-28 98.3 2.0 2.7e-28 98.2 0.0 1.9 2 0 0 2 2 2 1 Signal recognition particle 14kD protein DUF4449 PF14613.6 EMD66573.1 - 0.0022 18.1 1.7 0.0028 17.8 1.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF4449) AAA_13 PF13166.6 EMD66573.1 - 0.035 12.8 1.7 0.043 12.5 0.8 1.5 2 0 0 2 2 2 0 AAA domain DOPA_dioxygen PF08883.11 EMD66574.1 - 6.5e-46 154.9 0.0 8e-46 154.6 0.0 1.1 1 0 0 1 1 1 1 Dopa 4,5-dioxygenase family tRNA-synt_2 PF00152.20 EMD66575.1 - 3.6e-86 289.1 0.7 4.7e-86 288.7 0.1 1.4 2 0 0 2 2 2 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EMD66575.1 - 2.5e-08 33.8 0.0 5.3e-08 32.7 0.0 1.6 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain DUF3987 PF13148.6 EMD66575.1 - 4.1 6.3 6.4 7 5.6 6.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) PHD PF00628.29 EMD66576.1 - 2.2e-12 46.7 25.4 1.1e-07 31.6 11.1 2.5 2 0 0 2 2 2 2 PHD-finger Peptidase_M24 PF00557.24 EMD66576.1 - 2.4e-06 27.4 0.0 5.3e-06 26.3 0.0 1.6 1 0 0 1 1 1 1 Metallopeptidase family M24 C1_1 PF00130.22 EMD66576.1 - 0.12 12.3 19.5 0.088 12.7 6.3 2.6 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Endonuclease_7 PF02945.15 EMD66576.1 - 0.21 11.5 1.3 1.3 9.0 0.7 2.4 2 0 0 2 2 2 0 Recombination endonuclease VII Hydin_ADK PF17213.3 EMD66576.1 - 1.6 9.0 7.2 0.1 12.9 0.6 2.4 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain SPT6_acidic PF14632.6 EMD66576.1 - 7.3 7.3 14.4 1.1 10.0 0.9 3.3 3 0 0 3 3 3 0 Acidic N-terminal SPT6 SNF5 PF04855.12 EMD66577.1 - 2.6e-66 223.8 1.5 5.7e-65 219.4 1.5 2.3 1 1 0 1 1 1 1 SNF5 / SMARCB1 / INI1 TFIIA_gamma_N PF02268.16 EMD66577.1 - 0.072 13.1 0.2 0.15 12.1 0.2 1.5 1 0 0 1 1 1 0 Transcription initiation factor IIA, gamma subunit, helical domain GPP34 PF05719.11 EMD66578.1 - 1.7e-68 230.7 0.1 2.1e-68 230.4 0.1 1.1 1 0 0 1 1 1 1 Golgi phosphoprotein 3 (GPP34) PP-binding PF00550.25 EMD66579.1 - 2.4e-11 43.8 0.1 3.4e-11 43.3 0.1 1.2 1 0 0 1 1 1 1 Phosphopantetheine attachment site PP-binding_2 PF14573.6 EMD66579.1 - 1.8e-07 31.3 0.1 3.2e-07 30.5 0.2 1.4 2 0 0 2 2 2 1 Acyl-carrier REC104 PF17378.2 EMD66579.1 - 0.073 12.9 0.3 0.13 12.1 0.3 1.4 1 1 1 2 2 2 0 Meiotic recombination protein REC104 Fer4 PF00037.27 EMD66580.1 - 2.3e-14 52.5 15.3 2.1e-08 33.7 3.5 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_7 PF12838.7 EMD66580.1 - 5.6e-13 49.3 9.8 8.4e-13 48.7 9.8 1.3 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_16 PF13484.6 EMD66580.1 - 7.4e-11 42.8 7.6 2.9e-05 24.9 0.5 2.2 2 0 0 2 2 2 2 4Fe-4S double cluster binding domain Fer4_21 PF14697.6 EMD66580.1 - 1.5e-10 41.0 31.8 6.8e-07 29.3 11.8 2.0 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_10 PF13237.6 EMD66580.1 - 4.4e-09 36.3 21.3 2.6e-06 27.5 12.4 2.1 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_9 PF13187.6 EMD66580.1 - 1.8e-08 34.4 10.2 3e-08 33.7 10.2 1.4 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_8 PF13183.6 EMD66580.1 - 2.6e-07 31.0 19.0 0.00011 22.6 11.1 2.2 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_6 PF12837.7 EMD66580.1 - 9.6e-07 28.6 16.9 0.0004 20.3 5.4 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_2 PF12797.7 EMD66580.1 - 3.8e-06 26.7 12.1 0.0082 16.2 1.7 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_4 PF12800.7 EMD66580.1 - 6.8e-06 26.2 10.8 0.0003 21.1 1.8 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_17 PF13534.6 EMD66580.1 - 0.00023 21.7 12.2 0.005 17.4 12.7 2.2 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_3 PF12798.7 EMD66580.1 - 0.011 16.6 15.7 0.018 15.9 3.5 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_13 PF13370.6 EMD66580.1 - 0.028 15.0 15.1 0.75 10.4 4.3 2.6 2 1 0 2 2 2 0 4Fe-4S single cluster domain of Ferredoxin I c-SKI_SMAD_bind PF08782.10 EMD66580.1 - 0.028 14.6 5.1 1 9.6 0.3 2.2 1 1 1 2 2 2 0 c-SKI Smad4 binding domain Fer4_18 PF13746.6 EMD66580.1 - 0.076 13.2 8.9 2.8 8.1 1.2 2.2 1 1 1 2 2 2 0 4Fe-4S dicluster domain ETF_QO PF05187.13 EMD66580.1 - 0.076 13.2 5.2 0.35 11.0 0.4 2.2 1 1 1 2 2 2 0 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S Fer4_22 PF17179.4 EMD66580.1 - 0.66 10.8 11.6 1.6 9.6 1.4 2.2 1 1 1 2 2 2 0 4Fe-4S dicluster domain SURF6 PF04935.12 EMD66581.1 - 4.4e-45 154.0 45.3 4.4e-45 154.0 45.3 3.5 2 1 1 3 3 3 1 Surfeit locus protein 6 RRP14 PF15459.6 EMD66581.1 - 1.9e-16 60.4 0.6 1.9e-16 60.4 0.6 9.2 5 2 1 7 7 7 1 60S ribosome biogenesis protein Rrp14 MIT PF04212.18 EMD66585.1 - 3.8e-15 55.7 2.1 8.3e-15 54.6 2.1 1.6 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain PCI PF01399.27 EMD66586.1 - 2.7e-06 27.8 0.0 6.5e-06 26.6 0.0 1.6 1 0 0 1 1 1 1 PCI domain TPR_8 PF13181.6 EMD66586.1 - 0.0019 18.2 2.4 0.088 13.1 0.2 3.1 2 0 0 2 2 2 1 Tetratricopeptide repeat LUD_dom PF02589.15 EMD66586.1 - 0.019 14.7 0.1 0.051 13.3 0.1 1.7 1 0 0 1 1 1 0 LUD domain WBS_methylT PF12589.8 EMD66586.1 - 0.1 13.4 0.6 0.24 12.2 0.6 1.6 1 0 0 1 1 1 0 Methyltransferase involved in Williams-Beuren syndrome TPR_2 PF07719.17 EMD66586.1 - 0.16 12.2 0.9 3.9 7.8 0.1 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF2399 PF09664.10 EMD66586.1 - 0.19 11.6 1.1 1.6 8.7 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function C-terminus (DUF2399) Mad3_BUB1_I PF08311.12 EMD66587.1 - 2e-45 153.8 4.3 1e-44 151.4 1.5 2.7 3 0 0 3 3 3 1 Mad3/BUB1 homology region 1 Pkinase PF00069.25 EMD66587.1 - 1.6e-16 60.5 0.0 1.1e-15 57.7 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Mad3_BUB1_II PF08171.11 EMD66587.1 - 5.7e-09 36.0 0.0 2.8e-08 33.8 0.0 2.2 2 0 0 2 2 2 1 Mad3/BUB1 homology region 2 Pkinase_Tyr PF07714.17 EMD66587.1 - 9.7e-08 31.6 0.2 4.5e-07 29.4 0.2 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Mad3_BUB1_I_2 PF17014.5 EMD66587.1 - 0.02 15.0 0.0 0.049 13.8 0.0 1.6 1 0 0 1 1 1 0 Putative Mad3/BUB1 like region 1 protein APH PF01636.23 EMD66587.1 - 0.039 13.9 0.0 0.039 13.9 0.0 2.0 3 0 0 3 3 3 0 Phosphotransferase enzyme family Kdo PF06293.14 EMD66587.1 - 0.051 12.9 0.1 0.83 9.0 0.0 2.4 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EMD66587.1 - 0.13 11.6 0.0 0.4 9.9 0.0 1.7 2 0 0 2 2 2 0 Kinase-like ADH_zinc_N PF00107.26 EMD66588.1 - 6e-27 94.2 0.2 1.1e-26 93.3 0.2 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EMD66588.1 - 2.1e-19 69.4 2.6 2.1e-19 69.4 2.6 1.9 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 EMD66588.1 - 1.9e-05 25.7 0.0 3.5e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 EMD66588.1 - 0.00023 20.5 0.1 0.00037 19.9 0.1 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain TrkA_N PF02254.18 EMD66588.1 - 0.0017 18.6 0.0 0.0034 17.6 0.0 1.5 1 0 0 1 1 1 1 TrkA-N domain 2-Hacid_dh_C PF02826.19 EMD66588.1 - 0.0019 17.6 0.0 0.0036 16.7 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Methyltransf_25 PF13649.6 EMD66588.1 - 0.0081 16.8 1.5 0.013 16.2 0.1 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMD66588.1 - 0.011 15.5 0.2 0.023 14.5 0.2 1.5 1 0 0 1 1 1 0 Methyltransferase domain 3HCDH_N PF02737.18 EMD66588.1 - 0.014 15.3 0.1 0.022 14.7 0.1 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.14 EMD66588.1 - 0.015 14.9 0.2 0.03 13.9 0.2 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain PglD_N PF17836.1 EMD66588.1 - 1 10.0 7.4 0.85 10.3 1.7 3.1 3 1 0 3 3 3 0 PglD N-terminal domain Glyco_hydro_15 PF00723.21 EMD66590.1 - 2e-53 181.8 0.0 4.6e-51 174.0 0.0 2.2 1 1 0 1 1 1 1 Glycosyl hydrolases family 15 TP_methylase PF00590.20 EMD66591.1 - 6.1e-24 85.1 0.4 1.2e-23 84.2 0.4 1.5 1 1 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases TFIID-18kDa PF02269.16 EMD66592.1 - 2e-26 91.8 0.2 8.3e-26 89.8 0.1 2.0 2 0 0 2 2 2 1 Transcription initiation factor IID, 18kD subunit CENP-T_C PF15511.6 EMD66592.1 - 0.039 14.1 0.1 0.079 13.1 0.1 1.4 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T histone fold TAFII28 PF04719.14 EMD66592.1 - 0.11 12.6 0.3 0.28 11.3 0.3 1.8 1 1 0 1 1 1 0 hTAFII28-like protein conserved region Ribosomal_L19e PF01280.20 EMD66593.1 - 6.2e-57 191.7 7.1 6.2e-57 191.7 7.1 2.0 2 0 0 2 2 2 1 Ribosomal protein L19e FUSC_2 PF13515.6 EMD66593.1 - 1.1e-30 106.4 6.6 1.1e-30 106.4 6.6 2.5 2 0 0 2 2 2 1 Fusaric acid resistance protein-like ALMT PF11744.8 EMD66593.1 - 7.5e-05 21.7 23.1 0.013 14.4 0.1 5.1 5 1 0 5 5 5 3 Aluminium activated malate transporter ArAE_2 PF10334.9 EMD66593.1 - 0.00063 19.6 0.5 0.0029 17.5 0.1 2.2 2 0 0 2 2 2 1 Aromatic acid exporter family member 2 FUSC PF04632.12 EMD66593.1 - 0.00063 18.4 9.9 0.019 13.5 8.0 3.3 2 1 0 2 2 2 1 Fusaric acid resistance protein family MPLKIP PF15502.6 EMD66594.1 - 1.6e-05 25.0 0.0 4.5e-05 23.6 0.0 1.8 2 0 0 2 2 2 1 M-phase-specific PLK1-interacting protein SNRNP27 PF08648.12 EMD66594.1 - 0.00055 19.9 0.1 0.0013 18.7 0.1 1.6 1 0 0 1 1 1 1 U4/U6.U5 small nuclear ribonucleoproteins KxDL PF10241.9 EMD66595.1 - 5.2e-30 103.6 0.3 6.7e-30 103.2 0.3 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein DUF4407 PF14362.6 EMD66595.1 - 0.019 14.3 0.8 0.022 14.1 0.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) AAA PF00004.29 EMD66596.1 - 1.9e-55 186.9 0.0 1.4e-39 135.5 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) CDC48_2 PF02933.17 EMD66596.1 - 3.1e-10 39.7 0.3 5.7e-09 35.6 0.0 2.5 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), domain 2 AAA_16 PF13191.6 EMD66596.1 - 4.9e-10 40.0 0.1 0.0011 19.4 0.0 3.0 2 1 0 2 2 2 2 AAA ATPase domain AAA_5 PF07728.14 EMD66596.1 - 4.5e-09 36.4 0.2 0.0016 18.5 0.1 3.4 3 0 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA_lid_3 PF17862.1 EMD66596.1 - 7.9e-09 35.2 0.1 3.2e-08 33.3 0.0 2.1 2 0 0 2 2 1 1 AAA+ lid domain AAA_22 PF13401.6 EMD66596.1 - 8e-09 35.9 0.1 0.00083 19.6 0.0 3.3 2 2 1 3 3 3 2 AAA domain TIP49 PF06068.13 EMD66596.1 - 2.3e-07 30.4 0.0 0.0069 15.6 0.0 2.2 2 0 0 2 2 2 2 TIP49 P-loop domain RuvB_N PF05496.12 EMD66596.1 - 2.3e-07 30.7 0.2 0.036 13.8 0.0 3.0 4 0 0 4 4 2 2 Holliday junction DNA helicase RuvB P-loop domain Mg_chelatase PF01078.21 EMD66596.1 - 4.7e-07 29.4 0.1 0.0052 16.2 0.0 2.3 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 EMD66596.1 - 5.4e-07 29.9 0.0 0.012 15.7 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 EMD66596.1 - 1.9e-06 28.5 0.0 0.099 13.2 0.0 3.4 3 1 1 4 4 3 2 AAA domain RNA_helicase PF00910.22 EMD66596.1 - 2e-06 28.2 0.0 0.06 13.7 0.0 2.6 2 0 0 2 2 2 2 RNA helicase AAA_24 PF13479.6 EMD66596.1 - 2e-06 27.7 0.0 0.02 14.6 0.0 2.6 2 1 0 2 2 2 2 AAA domain AAA_2 PF07724.14 EMD66596.1 - 2.7e-06 27.6 0.0 0.00016 21.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) NACHT PF05729.12 EMD66596.1 - 2e-05 24.5 0.3 0.032 14.2 0.0 3.0 3 0 0 3 3 2 1 NACHT domain ATPase PF06745.13 EMD66596.1 - 3.7e-05 23.2 0.1 0.015 14.7 0.0 2.6 2 1 0 2 2 2 1 KaiC AAA_7 PF12775.7 EMD66596.1 - 5.3e-05 22.8 0.1 0.11 12.0 0.0 2.7 3 0 0 3 3 2 2 P-loop containing dynein motor region IstB_IS21 PF01695.17 EMD66596.1 - 6.6e-05 22.7 0.0 0.25 11.0 0.0 2.5 2 0 0 2 2 2 2 IstB-like ATP binding protein Sigma54_activat PF00158.26 EMD66596.1 - 9.4e-05 22.2 0.0 0.26 11.0 0.0 2.7 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_17 PF13207.6 EMD66596.1 - 0.00012 22.6 0.1 0.12 12.8 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.6 EMD66596.1 - 0.00012 22.4 0.0 0.4 10.9 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_14 PF13173.6 EMD66596.1 - 0.00014 21.9 0.0 0.57 10.2 0.0 2.5 2 0 0 2 2 2 2 AAA domain TsaE PF02367.17 EMD66596.1 - 0.00017 21.6 0.0 0.36 10.8 0.0 2.3 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATPase_2 PF01637.18 EMD66596.1 - 0.00017 21.6 0.2 1.1 9.2 0.0 3.2 2 1 1 3 3 3 1 ATPase domain predominantly from Archaea AAA_11 PF13086.6 EMD66596.1 - 0.00018 21.4 0.0 0.49 10.1 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.6 EMD66596.1 - 0.00022 20.9 0.1 0.79 9.3 0.1 3.1 2 1 1 3 3 3 2 AAA domain AAA_30 PF13604.6 EMD66596.1 - 0.00037 20.3 0.0 0.17 11.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain PhoH PF02562.16 EMD66596.1 - 0.00083 18.9 0.0 0.7 9.3 0.0 2.3 2 0 0 2 2 2 2 PhoH-like protein CDC48_N PF02359.18 EMD66596.1 - 0.00088 19.4 0.0 0.0022 18.2 0.0 1.6 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain AAA_19 PF13245.6 EMD66596.1 - 0.0015 18.9 0.1 1.6 9.1 0.0 3.1 3 0 0 3 3 3 1 AAA domain NB-ARC PF00931.22 EMD66596.1 - 0.0016 17.7 0.0 0.81 8.8 0.0 2.4 2 0 0 2 2 2 1 NB-ARC domain AAA_3 PF07726.11 EMD66596.1 - 0.0026 17.6 0.0 0.55 10.1 0.0 2.4 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.27 EMD66596.1 - 0.0029 18.1 0.1 0.36 11.3 0.1 2.6 2 0 0 2 2 2 1 ABC transporter DUF2075 PF09848.9 EMD66596.1 - 0.011 15.0 0.2 5.5 6.1 0.1 2.7 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) KTI12 PF08433.10 EMD66596.1 - 0.014 14.8 0.0 3.4 7.0 0.0 2.3 2 0 0 2 2 2 0 Chromatin associated protein KTI12 ResIII PF04851.15 EMD66596.1 - 0.024 14.6 0.0 4.7 7.2 0.0 2.6 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit Sigma54_activ_2 PF14532.6 EMD66596.1 - 0.025 14.7 0.0 5 7.3 0.0 2.9 3 0 0 3 3 2 0 Sigma-54 interaction domain Rad17 PF03215.15 EMD66596.1 - 0.035 14.0 0.0 2.7 7.9 0.0 2.6 3 0 0 3 3 2 0 Rad17 P-loop domain IPT PF01745.16 EMD66596.1 - 0.071 12.5 0.0 1.5 8.1 0.0 2.2 2 0 0 2 2 2 0 Isopentenyl transferase Parvo_NS1 PF01057.17 EMD66596.1 - 0.083 12.0 0.0 1.9 7.5 0.0 2.2 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 SRP54 PF00448.22 EMD66596.1 - 0.092 12.4 0.0 3.4 7.2 0.0 2.6 3 0 0 3 3 2 0 SRP54-type protein, GTPase domain NTPase_1 PF03266.15 EMD66596.1 - 0.11 12.4 0.0 22 4.9 0.0 2.5 2 0 0 2 2 2 0 NTPase Zeta_toxin PF06414.12 EMD66596.1 - 0.12 11.7 0.0 1.6 7.9 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin WD40 PF00400.32 EMD66597.1 - 6.3e-14 52.2 6.1 0.16 12.9 0.5 6.9 7 0 0 7 7 7 5 WD domain, G-beta repeat CDC45 PF02724.14 EMD66597.1 - 1.3 7.2 15.1 1.8 6.7 15.1 1.1 1 0 0 1 1 1 0 CDC45-like protein SDA1 PF05285.12 EMD66597.1 - 4.1 6.7 25.2 7.5 5.9 25.2 1.4 1 0 0 1 1 1 0 SDA1 MscL PF01741.18 EMD66599.1 - 1e-19 71.0 0.1 1.3e-19 70.7 0.1 1.1 1 0 0 1 1 1 1 Large-conductance mechanosensitive channel, MscL Abhydrolase_1 PF00561.20 EMD66600.1 - 1.6e-13 50.9 0.0 3.3e-13 49.9 0.0 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EMD66600.1 - 3.6e-12 47.3 0.0 7.6e-12 46.3 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EMD66600.1 - 1.7e-08 34.0 0.0 3.2e-08 33.1 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Ndr PF03096.14 EMD66600.1 - 1.2e-06 27.5 0.0 1.7e-06 27.0 0.0 1.2 1 0 0 1 1 1 1 Ndr family EthD PF07110.11 EMD66600.1 - 4.3e-06 27.8 0.3 0.026 15.7 0.0 3.0 3 0 0 3 3 3 2 EthD domain Esterase PF00756.20 EMD66600.1 - 0.00034 20.3 0.0 0.00078 19.2 0.0 1.5 1 0 0 1 1 1 1 Putative esterase GH-E PF14410.6 EMD66600.1 - 0.069 13.6 0.0 9.2 6.7 0.0 2.7 2 0 0 2 2 2 0 HNH/ENDO VII superfamily nuclease with conserved GHE residues Lactonase PF10282.9 EMD66601.1 - 1.4e-12 47.6 0.0 3.6e-12 46.2 0.0 1.6 1 1 0 1 1 1 1 Lactonase, 7-bladed beta-propeller Dioxygenase_C PF00775.21 EMD66602.1 - 2.3e-43 147.8 0.0 4e-43 147.0 0.0 1.4 1 0 0 1 1 1 1 Dioxygenase Acyl-CoA_dh_1 PF00441.24 EMD66602.1 - 1.6e-41 142.0 0.4 3.1e-41 141.1 0.4 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 EMD66602.1 - 2.9e-33 114.9 0.1 7.6e-33 113.5 0.1 1.8 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 EMD66602.1 - 7.6e-26 90.2 0.2 1.8e-25 89.0 0.2 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Dioxygenase_N PF04444.14 EMD66602.1 - 5.5e-25 87.0 0.3 1.1e-24 86.0 0.3 1.5 1 0 0 1 1 1 1 Catechol dioxygenase N terminus Acyl-CoA_dh_2 PF08028.11 EMD66602.1 - 2.3e-15 57.1 0.0 5e-15 56.0 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain CMD PF02627.20 EMD66602.1 - 2e-08 34.2 0.1 4.9e-08 32.9 0.1 1.7 1 0 0 1 1 1 1 Carboxymuconolactone decarboxylase family HpaB_N PF11794.8 EMD66602.1 - 2.7e-05 24.0 0.3 7.9e-05 22.4 0.3 1.8 1 1 0 1 1 1 1 4-hydroxyphenylacetate 3-hydroxylase N terminal CarboxypepD_reg PF13620.6 EMD66602.1 - 0.058 13.7 0.0 0.22 11.8 0.0 2.0 1 0 0 1 1 1 0 Carboxypeptidase regulatory-like domain BRCA-2_OB3 PF09104.10 EMD66603.1 - 0.12 12.0 0.0 0.2 11.3 0.0 1.3 1 0 0 1 1 1 0 BRCA2, oligonucleotide/oligosaccharide-binding, domain 3 TPR_1 PF00515.28 EMD66604.1 - 2.5e-09 36.6 2.0 0.00084 19.1 0.0 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 EMD66604.1 - 4.5e-07 29.5 2.3 0.28 11.4 0.2 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 EMD66604.1 - 0.024 14.8 3.7 20 5.7 0.0 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 EMD66604.1 - 0.024 15.1 0.1 0.099 13.2 0.0 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EMD66604.1 - 0.055 13.7 0.5 0.14 12.4 0.5 1.7 1 1 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 Pox_T4_N PF04491.12 EMD66604.1 - 0.18 11.7 0.1 1.5 8.7 0.0 2.5 3 0 0 3 3 3 0 Poxvirus T4 protein, N terminus Mcp5_PH PF12814.7 EMD66605.1 - 6.1e-45 152.3 0.0 1.3e-44 151.3 0.0 1.6 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology TPR_MLP1_2 PF07926.12 EMD66605.1 - 0.61 10.2 16.7 1 9.4 1.9 3.0 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Golgin_A5 PF09787.9 EMD66605.1 - 1.1 8.7 14.2 2 7.8 14.2 1.4 1 0 0 1 1 1 0 Golgin subfamily A member 5 Exonuc_VII_L PF02601.15 EMD66605.1 - 1.2 8.6 7.4 2.5 7.6 7.4 1.5 1 0 0 1 1 1 0 Exonuclease VII, large subunit CENP-H PF05837.12 EMD66605.1 - 4.3 7.8 13.7 3.1 8.2 2.2 2.7 1 1 1 2 2 2 0 Centromere protein H (CENP-H) AMP-binding PF00501.28 EMD66606.1 - 5.5e-78 262.4 0.0 7.2e-78 262.1 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EMD66606.1 - 1.6e-14 54.6 0.2 3.9e-14 53.4 0.2 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain SHMT PF00464.19 EMD66608.1 - 2.9e-199 661.7 0.0 3.4e-199 661.5 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase MAD PF05557.13 EMD66610.1 - 5.6e-65 220.0 77.2 7.7e-65 219.5 77.2 1.1 1 0 0 1 1 1 1 Mitotic checkpoint protein Seryl_tRNA_N PF02403.22 EMD66610.1 - 0.01 16.1 10.3 0.01 16.1 10.3 7.0 2 2 2 6 6 6 2 Seryl-tRNA synthetase N-terminal domain GIT_CC PF16559.5 EMD66610.1 - 0.06 13.2 0.4 0.06 13.2 0.4 8.6 9 2 0 10 10 10 0 GIT coiled-coil Rho guanine nucleotide exchange factor Nup54_57_C PF18570.1 EMD66610.1 - 0.93 9.1 12.6 1.2 8.7 0.1 4.8 4 0 0 4 4 4 0 NUP57/Nup54 C-terminal domain Spc7 PF08317.11 EMD66610.1 - 1.2 8.0 102.7 0.28 10.0 14.4 6.1 1 1 5 6 6 6 0 Spc7 kinetochore protein LCM PF04072.14 EMD66611.1 - 1.1e-22 80.9 0.0 3.1e-22 79.4 0.0 1.7 1 1 0 1 1 1 1 Leucine carboxyl methyltransferase RNA_pol_Rpb5_C PF01191.19 EMD66612.1 - 7.3e-34 115.5 0.2 1.1e-33 114.9 0.2 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb5, C-terminal domain RNA_pol_Rpb5_N PF03871.14 EMD66612.1 - 2e-27 95.6 0.0 3.7e-27 94.7 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb5, N-terminal domain LigT_PEase PF02834.16 EMD66613.1 - 0.13 12.5 0.1 1 9.6 0.1 2.4 3 0 0 3 3 3 0 LigT like Phosphoesterase GGDEF_2 PF17853.1 EMD66613.1 - 0.16 12.2 0.0 0.41 10.9 0.0 1.6 1 0 0 1 1 1 0 GGDEF-like domain SKG6 PF08693.10 EMD66614.1 - 0.016 14.6 3.8 0.026 13.9 3.8 1.3 1 0 0 1 1 1 0 Transmembrane alpha-helix domain DUF1772 PF08592.11 EMD66614.1 - 0.083 13.2 0.1 0.5 10.7 0.1 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF1772) CcmD PF04995.14 EMD66614.1 - 0.45 10.6 3.7 0.79 9.8 3.7 1.4 1 0 0 1 1 1 0 Heme exporter protein D (CcmD) SKG6 PF08693.10 EMD66615.1 - 0.0051 16.2 0.9 0.0094 15.3 0.9 1.4 1 0 0 1 1 1 1 Transmembrane alpha-helix domain MLANA PF14991.6 EMD66615.1 - 0.025 14.9 0.0 0.045 14.0 0.0 1.4 1 0 0 1 1 1 0 Protein melan-A Collagen PF01391.18 EMD66615.1 - 0.057 13.2 9.7 0.13 12.1 9.7 1.6 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) CCB1 PF12046.8 EMD66615.1 - 0.11 11.8 0.0 0.16 11.3 0.0 1.2 1 0 0 1 1 1 0 Cofactor assembly of complex C subunit B VPDSG-CTERM PF18205.1 EMD66615.1 - 0.85 9.5 5.0 2.3 8.1 5.0 1.8 1 0 0 1 1 1 0 VPDSG-CTERM motif AP3D1 PF06375.11 EMD66617.1 - 0.0025 18.1 3.6 0.0028 17.9 3.6 1.1 1 0 0 1 1 1 1 AP-3 complex subunit delta-1 GAGA_bind PF06217.12 EMD66617.1 - 0.023 15.0 2.0 0.025 14.9 2.0 1.0 1 0 0 1 1 1 0 GAGA binding protein-like family Peptidase_S49_N PF08496.10 EMD66617.1 - 0.073 13.1 0.0 0.076 13.1 0.0 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal BRF1 PF07741.13 EMD66617.1 - 0.14 12.5 4.6 0.18 12.1 4.6 1.2 1 0 0 1 1 1 0 Brf1-like TBP-binding domain AA_permease PF00324.21 EMD66619.1 - 9e-128 426.9 50.3 1.1e-127 426.6 50.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 EMD66619.1 - 8.1e-31 107.3 55.8 1e-30 107.0 55.8 1.1 1 0 0 1 1 1 1 Amino acid permease DUF4781 PF16013.5 EMD66619.1 - 0.18 10.6 4.6 2.2 7.0 0.9 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4781) TssO PF17561.2 EMD66619.1 - 0.27 11.3 0.1 0.78 9.8 0.1 1.8 1 0 0 1 1 1 0 Type VI secretion system, TssO Hydrophobin_2 PF06766.11 EMD66620.1 - 1.5e-22 79.3 10.4 1.9e-22 78.9 10.4 1.1 1 0 0 1 1 1 1 Fungal hydrophobin Defensin_beta PF00711.19 EMD66620.1 - 0.14 12.2 0.2 0.14 12.2 0.2 2.3 2 0 0 2 2 2 0 Beta defensin DUF5547 PF17701.1 EMD66621.1 - 0.052 13.4 0.0 0.13 12.1 0.0 1.6 2 0 0 2 2 2 0 Family of unknown function (DUF5547) ApbA_C PF08546.11 EMD66622.1 - 3.2e-30 104.9 0.4 5e-30 104.3 0.4 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.16 EMD66622.1 - 1.1e-25 90.1 0.0 1.5e-25 89.6 0.0 1.2 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Herpes_gE PF02480.16 EMD66623.1 - 0.17 10.6 0.0 0.23 10.2 0.0 1.1 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E Gram_pos_anchor PF00746.21 EMD66623.1 - 1.7 8.6 4.1 3.6 7.6 4.1 1.5 1 0 0 1 1 1 0 LPXTG cell wall anchor motif zf-UBR PF02207.20 EMD66625.1 - 5.9e-19 68.0 13.4 5.9e-19 68.0 13.4 1.9 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) ClpS PF02617.17 EMD66625.1 - 0.00021 21.0 0.1 0.00055 19.7 0.1 1.7 1 0 0 1 1 1 1 ATP-dependent Clp protease adaptor protein ClpS zf-RING_2 PF13639.6 EMD66625.1 - 0.02 15.2 0.8 0.02 15.2 0.8 4.0 4 1 0 4 4 4 0 Ring finger domain FAM176 PF14851.6 EMD66625.1 - 0.42 10.3 2.9 1.2 8.8 2.9 1.7 1 0 0 1 1 1 0 FAM176 family CAP_N PF01213.19 EMD66625.1 - 0.78 9.2 5.1 1.7 8.1 5.1 1.4 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal UCR_UQCRX_QCR9 PF05365.12 EMD66626.1 - 2.9e-24 84.8 0.7 3.2e-24 84.6 0.7 1.0 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like Mago-bind PF09282.10 EMD66627.1 - 2.3e-15 56.2 5.2 4.5e-15 55.2 5.2 1.5 1 0 0 1 1 1 1 Mago binding GET2 PF08690.10 EMD66627.1 - 0.49 10.0 6.9 0.62 9.7 6.9 1.1 1 0 0 1 1 1 0 GET complex subunit GET2 Trypan_PARP PF05887.11 EMD66627.1 - 1 9.3 11.4 1.9 8.5 11.4 1.4 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) NPR3 PF03666.13 EMD66627.1 - 3.7 6.2 8.2 3.7 6.2 8.2 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 RR_TM4-6 PF06459.12 EMD66627.1 - 9.7 5.9 15.6 12 5.6 15.6 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SWI-SNF_Ssr4 PF08549.10 EMD66629.1 - 1.9e-187 625.2 28.6 8.8e-186 619.7 28.6 2.0 1 1 0 1 1 1 1 Fungal domain of unknown function (DUF1750) Acyl_transf_3 PF01757.22 EMD66630.1 - 2.4e-15 56.4 20.5 3.6e-15 55.9 20.5 1.3 1 0 0 1 1 1 1 Acyltransferase family Band_7 PF01145.25 EMD66631.1 - 2.5e-30 105.8 3.4 2.5e-30 105.8 3.4 1.5 2 0 0 2 2 2 1 SPFH domain / Band 7 family Band_7_1 PF13421.6 EMD66631.1 - 0.0097 15.6 0.3 0.017 14.8 0.3 1.5 1 0 0 1 1 1 1 SPFH domain-Band 7 family Kinesin_assoc PF16183.5 EMD66631.1 - 0.42 10.8 3.8 0.86 9.7 3.2 1.8 1 1 0 1 1 1 0 Kinesin-associated OST3_OST6 PF04756.13 EMD66633.1 - 7.1e-106 353.8 0.0 8.1e-106 353.6 0.0 1.0 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family QCR10 PF09796.9 EMD66633.1 - 0.025 14.6 4.6 1.1 9.4 0.1 3.0 2 2 1 3 3 3 0 Ubiquinol-cytochrome-c reductase complex subunit (QCR10) CPBP PF02517.16 EMD66633.1 - 0.54 10.7 4.8 3.9 7.9 5.0 2.1 1 1 0 1 1 1 0 CPBP intramembrane metalloprotease DUF4449 PF14613.6 EMD66634.1 - 5e-06 26.7 0.1 5e-06 26.7 0.1 3.0 4 0 0 4 4 4 1 Protein of unknown function (DUF4449) AbiH PF14253.6 EMD66634.1 - 0.019 14.9 2.0 0.055 13.3 0.8 2.1 2 0 0 2 2 2 0 Bacteriophage abortive infection AbiH DUF1828 PF08861.10 EMD66634.1 - 0.11 12.8 0.0 0.56 10.5 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function DUF1828 Tricorn_C1 PF14684.6 EMD66634.1 - 0.13 12.4 0.2 0.6 10.2 0.1 2.3 2 0 0 2 2 2 0 Tricorn protease C1 domain DUF4208 PF13907.6 EMD66634.1 - 2.9 8.4 6.2 2.8 8.4 0.5 3.5 2 1 2 4 4 4 0 Domain of unknown function (DUF4208) Malic_M PF03949.15 EMD66635.1 - 4.3e-93 311.3 0.0 5.4e-93 311.0 0.0 1.1 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 EMD66635.1 - 7e-62 208.5 0.0 1.3e-61 207.6 0.0 1.4 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain DTHCT PF08070.11 EMD66636.1 - 0.009 16.7 12.5 0.013 16.2 12.5 1.3 1 0 0 1 1 1 1 DTHCT (NUC029) region GEMIN8 PF15348.6 EMD66636.1 - 0.042 14.2 0.9 0.048 14.0 0.9 1.0 1 0 0 1 1 1 0 Gemini of Cajal bodies-associated protein 8 AT_hook PF02178.19 EMD66636.1 - 0.074 13.0 5.9 0.074 13.0 5.9 2.6 3 0 0 3 3 3 0 AT hook motif FSH1 PF03959.13 EMD66636.1 - 0.19 11.4 0.1 0.21 11.2 0.1 1.2 1 0 0 1 1 1 0 Serine hydrolase (FSH1) eIF-3c_N PF05470.12 EMD66636.1 - 0.78 8.0 5.0 0.93 7.7 5.0 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus Patatin PF01734.22 EMD66638.1 - 3.1e-14 53.7 0.0 9.7e-14 52.0 0.0 1.8 1 1 0 1 1 1 1 Patatin-like phospholipase ApbA_C PF08546.11 EMD66639.1 - 8.1e-27 93.9 0.0 1.2e-26 93.4 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.16 EMD66639.1 - 2.6e-24 85.6 0.0 3.4e-24 85.2 0.0 1.2 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA NAD_binding_7 PF13241.6 EMD66639.1 - 0.011 16.1 0.0 0.021 15.2 0.0 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding IlvN PF07991.12 EMD66639.1 - 0.012 15.2 0.0 0.28 10.7 0.1 2.4 2 1 1 3 3 3 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain FAD_binding_3 PF01494.19 EMD66639.1 - 0.078 12.2 0.6 0.11 11.7 0.6 1.2 1 0 0 1 1 1 0 FAD binding domain ThiF PF00899.21 EMD66639.1 - 0.082 12.2 2.2 0.56 9.5 2.2 1.9 2 0 0 2 2 2 0 ThiF family Shikimate_DH PF01488.20 EMD66639.1 - 0.16 12.0 0.5 0.3 11.1 0.5 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase FAD_binding_2 PF00890.24 EMD66639.1 - 0.43 9.6 2.4 2.6 7.1 3.3 1.8 2 0 0 2 2 2 0 FAD binding domain DAO PF01266.24 EMD66639.1 - 0.67 9.5 5.4 2.2 7.7 5.1 1.8 2 0 0 2 2 2 0 FAD dependent oxidoreductase Ribosomal_L44 PF00935.19 EMD66640.1 - 1.6e-36 124.6 11.4 2.6e-36 124.0 11.4 1.3 1 0 0 1 1 1 1 Ribosomal protein L44 MSC PF09402.10 EMD66641.1 - 1.2e-102 343.8 0.0 1.8e-102 343.3 0.0 1.2 1 0 0 1 1 1 1 Man1-Src1p-C-terminal domain HeH PF12949.7 EMD66641.1 - 5.9e-14 51.5 0.0 1.3e-13 50.4 0.0 1.6 1 0 0 1 1 1 1 HeH/LEM domain NifQ PF04891.12 EMD66641.1 - 2.2 8.6 6.2 0.62 10.4 0.1 2.4 2 0 0 2 2 2 0 NifQ GH131_N PF18271.1 EMD66642.1 - 2.5e-60 204.3 4.2 2.8e-60 204.1 4.2 1.0 1 0 0 1 1 1 1 Glycoside hydrolase 131 catalytic N-terminal domain Polysacc_lyase PF14099.6 EMD66642.1 - 0.00035 20.5 7.5 0.00058 19.8 7.5 1.3 1 1 0 1 1 1 1 Polysaccharide lyase DUF2457 PF10446.9 EMD66643.1 - 0.62 9.1 8.3 0.73 8.9 8.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Patatin PF01734.22 EMD66644.1 - 1.4e-23 84.1 0.4 1.6e-22 80.7 0.4 2.3 1 1 0 1 1 1 1 Patatin-like phospholipase Inp1 PF12634.7 EMD66646.1 - 5.6e-36 123.6 0.0 1.4e-35 122.3 0.0 1.7 1 0 0 1 1 1 1 Inheritance of peroxisomes protein 1 EI24 PF07264.11 EMD66647.1 - 2.9e-14 53.7 0.0 5.6e-12 46.3 0.0 2.2 1 1 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) DUF2062 PF09835.9 EMD66647.1 - 0.0013 18.7 5.6 0.34 10.8 0.9 2.3 2 0 0 2 2 2 2 Uncharacterized protein conserved in bacteria (DUF2062) FmdA_AmdA PF03069.15 EMD66648.1 - 2.4e-178 592.7 0.0 2.7e-178 592.5 0.0 1.0 1 0 0 1 1 1 1 Acetamidase/Formamidase family Redoxin PF08534.10 EMD66649.1 - 6.4e-27 94.1 0.0 7.2e-27 93.9 0.0 1.0 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 EMD66649.1 - 4.9e-05 23.2 0.0 6.4e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family HSF_DNA-bind PF00447.17 EMD66650.1 - 4.4e-31 107.3 1.7 4.4e-31 107.3 1.7 2.5 2 0 0 2 2 1 1 HSF-type DNA-binding Response_reg PF00072.24 EMD66650.1 - 2e-22 79.5 0.0 4.7e-22 78.3 0.0 1.7 1 0 0 1 1 1 1 Response regulator receiver domain AAA_23 PF13476.6 EMD66650.1 - 0.014 15.9 11.5 0.048 14.1 9.1 2.1 2 0 0 2 2 2 0 AAA domain DDHD PF02862.17 EMD66650.1 - 0.18 11.9 14.4 0.19 11.9 12.6 1.9 2 0 0 2 2 2 0 DDHD domain RR_TM4-6 PF06459.12 EMD66650.1 - 0.19 11.5 12.9 0.37 10.6 12.9 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 TFIIA PF03153.13 EMD66650.1 - 0.24 11.4 60.3 0.049 13.6 48.6 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit CPSF100_C PF13299.6 EMD66650.1 - 0.42 10.8 12.5 0.99 9.6 12.5 1.6 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal SID-1_RNA_chan PF13965.6 EMD66650.1 - 0.42 9.0 3.8 0.56 8.5 3.8 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF3408 PF11888.8 EMD66650.1 - 0.66 10.1 14.4 1.9 8.6 14.4 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) SpoIIP PF07454.11 EMD66650.1 - 0.71 9.3 17.9 1.3 8.4 17.9 1.4 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Spt20 PF12090.8 EMD66650.1 - 0.87 9.1 52.9 0.27 10.8 48.3 2.6 2 0 0 2 2 2 0 Spt20 family TERB2 PF15101.6 EMD66650.1 - 1.4 9.0 21.7 2.8 7.9 21.7 1.4 1 0 0 1 1 1 0 Telomere-associated protein TERB2 EOS1 PF12326.8 EMD66650.1 - 1.5 8.7 6.8 2.7 7.9 6.8 1.4 1 0 0 1 1 1 0 N-glycosylation protein FAM60A PF15396.6 EMD66650.1 - 1.5 8.8 10.8 4.1 7.4 10.8 1.7 1 0 0 1 1 1 0 Protein Family FAM60A MMU163 PF17119.5 EMD66650.1 - 4.8 6.3 11.0 8.9 5.4 11.0 1.4 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis Hydin_ADK PF17213.3 EMD66650.1 - 5.8 7.1 12.1 18 5.6 12.1 1.8 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain LMBR1 PF04791.16 EMD66650.1 - 7.2 5.4 8.4 1.8 7.4 5.6 1.4 2 0 0 2 2 2 0 LMBR1-like membrane protein DUF4192 PF13830.6 EMD66650.1 - 9.9 6.1 6.7 17 5.4 6.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4192) W2 PF02020.18 EMD66651.1 - 8.2e-12 45.1 15.8 5.2e-11 42.5 15.4 2.6 2 1 0 2 2 2 1 eIF4-gamma/eIF5/eIF2-epsilon Hexapep PF00132.24 EMD66651.1 - 1.3e-10 40.5 12.7 7e-05 22.4 3.7 3.8 1 1 3 4 4 4 4 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 EMD66651.1 - 2.7e-07 30.2 9.8 0.041 13.6 0.3 3.5 2 1 1 3 3 3 3 Hexapeptide repeat of succinyl-transferase NTP_transferase PF00483.23 EMD66651.1 - 2.8e-06 27.1 0.0 4.8e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 EMD66651.1 - 0.00021 21.7 0.0 0.00039 20.8 0.0 1.5 1 0 0 1 1 1 1 MobA-like NTP transferase domain Fucokinase PF07959.12 EMD66651.1 - 0.021 13.8 0.8 0.17 10.8 0.8 2.2 1 1 0 1 1 1 0 L-fucokinase DUF4954 PF16314.5 EMD66651.1 - 0.057 11.6 1.6 0.14 10.3 0.7 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4954) IBR PF01485.21 EMD66652.1 - 9.3e-24 83.4 47.5 2.6e-13 50.0 7.5 4.6 3 1 1 4 4 4 3 IBR domain, a half RING-finger domain zf-C3HC4 PF00097.25 EMD66652.1 - 7.4e-05 22.5 4.4 7.4e-05 22.5 4.4 4.8 3 1 1 4 4 4 2 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EMD66652.1 - 0.00011 22.4 4.3 0.00011 22.4 4.3 4.3 2 1 1 3 3 3 1 Ring finger domain zf-RING_UBOX PF13445.6 EMD66652.1 - 0.0005 20.0 4.3 0.0005 20.0 4.3 3.7 3 0 0 3 3 3 2 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EMD66652.1 - 0.0025 17.6 6.2 0.0025 17.6 6.2 5.0 3 1 1 4 4 4 2 Zinc finger, C3HC4 type (RING finger) Trp_syntA PF00290.20 EMD66652.1 - 0.016 14.1 0.0 0.023 13.5 0.0 1.2 1 0 0 1 1 1 0 Tryptophan synthase alpha chain zf-RING_14 PF17978.1 EMD66652.1 - 0.034 14.6 2.1 0.034 14.6 2.1 3.6 3 1 1 4 4 4 0 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.6 EMD66652.1 - 2 8.6 32.9 0.32 11.2 3.7 4.5 3 1 0 3 3 3 0 zinc finger of C3HC4-type, RING DNA_ligase_ZBD PF03119.16 EMD66652.1 - 4.6 7.3 11.5 3.2 7.9 0.2 3.1 2 0 0 2 2 2 0 NAD-dependent DNA ligase C4 zinc finger domain Peptidase_S8 PF00082.22 EMD66654.1 - 1.5e-36 126.2 14.9 2.3e-36 125.6 14.9 1.3 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 EMD66654.1 - 1.5e-18 67.2 0.9 4.1e-18 65.8 0.9 1.8 1 0 0 1 1 1 1 Peptidase inhibitor I9 Beach PF02138.18 EMD66655.1 - 1.3e-117 392.1 0.3 2.3e-117 391.3 0.3 1.4 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.6 EMD66655.1 - 7.3e-10 38.8 1.9 3.2e-09 36.8 0.0 2.4 2 0 0 2 2 2 1 PH domain associated with Beige/BEACH Laminin_G_3 PF13385.6 EMD66655.1 - 1.7e-08 34.7 0.0 8.3e-08 32.5 0.0 2.0 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily WD40 PF00400.32 EMD66655.1 - 0.00011 22.9 0.1 3.6 8.6 0.0 4.9 4 0 0 4 4 4 1 WD domain, G-beta repeat Fungal_trans PF04082.18 EMD66656.1 - 2.2e-24 85.9 0.1 3.3e-24 85.4 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD66656.1 - 2.6e-15 56.2 30.8 5.1e-08 32.9 7.7 2.8 3 0 0 3 3 3 2 Fungal Zn(2)-Cys(6) binuclear cluster domain WD40 PF00400.32 EMD66657.1 - 3e-24 84.8 11.1 2.7e-08 34.3 0.0 6.4 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD66657.1 - 3.3e-08 33.7 0.8 0.012 15.9 0.0 3.6 2 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EMD66657.1 - 5e-06 25.7 0.1 0.0028 16.7 0.0 2.9 2 1 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 EMD66657.1 - 0.021 13.5 2.2 1 7.9 0.0 2.9 3 0 0 3 3 3 0 Nucleoporin Nup120/160 MFS_1 PF07690.16 EMD66658.1 - 2.4e-31 109.0 33.5 2.4e-31 109.0 33.5 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF1345 PF07077.11 EMD66658.1 - 0.035 13.8 4.8 1.7 8.4 0.5 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1345) PIG-Y PF15159.6 EMD66658.1 - 3.3 8.7 11.0 6.1 7.8 1.7 3.6 3 1 0 3 3 3 0 Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y ABC_membrane PF00664.23 EMD66659.1 - 4.2e-48 164.4 11.3 5.5e-48 164.0 11.3 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 EMD66659.1 - 1.9e-35 122.3 0.0 7.1e-35 120.5 0.0 2.0 2 0 0 2 2 1 1 ABC transporter SMC_N PF02463.19 EMD66659.1 - 1.1e-05 25.0 0.0 3e-05 23.5 0.0 1.9 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 EMD66659.1 - 0.0012 19.1 0.6 0.017 15.4 0.3 2.6 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EMD66659.1 - 0.0032 17.9 0.2 0.014 15.7 0.1 2.1 2 1 0 2 2 2 1 AAA ATPase domain AAA PF00004.29 EMD66659.1 - 0.0034 17.8 0.2 0.036 14.5 0.2 2.3 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DEAD PF00270.29 EMD66659.1 - 0.0052 16.6 0.2 0.03 14.1 0.2 2.0 1 1 0 1 1 1 1 DEAD/DEAH box helicase IstB_IS21 PF01695.17 EMD66659.1 - 0.033 13.9 0.1 4.3 7.0 0.0 2.3 2 0 0 2 2 2 0 IstB-like ATP binding protein DUF87 PF01935.17 EMD66659.1 - 0.037 14.1 1.5 0.3 11.1 0.1 2.4 2 0 0 2 2 2 0 Helicase HerA, central domain NTPase_1 PF03266.15 EMD66659.1 - 0.059 13.3 0.2 8 6.3 0.0 2.3 2 0 0 2 2 2 0 NTPase SbcCD_C PF13558.6 EMD66659.1 - 0.061 13.6 0.7 0.92 9.8 0.7 2.6 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_30 PF13604.6 EMD66659.1 - 0.082 12.6 0.1 0.23 11.1 0.1 1.7 1 1 0 1 1 1 0 AAA domain Cupin_2 PF07883.11 EMD66660.1 - 1.8e-13 50.0 0.3 3.6e-13 49.0 0.3 1.5 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.19 EMD66660.1 - 9.6e-08 32.0 0.0 1.4e-07 31.4 0.0 1.2 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_6 PF12852.7 EMD66660.1 - 5.1e-05 23.1 0.1 5.6e-05 22.9 0.1 1.1 1 0 0 1 1 1 1 Cupin Cupin_3 PF05899.12 EMD66660.1 - 0.00091 18.9 0.1 0.0021 17.7 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF861) ARD PF03079.14 EMD66660.1 - 0.0018 18.5 0.0 0.0029 17.8 0.0 1.3 1 0 0 1 1 1 1 ARD/ARD' family Cupin_1 PF00190.22 EMD66660.1 - 0.0053 16.4 0.1 0.0069 16.0 0.1 1.2 1 0 0 1 1 1 1 Cupin MannoseP_isomer PF01050.18 EMD66660.1 - 0.083 12.8 0.0 0.11 12.4 0.0 1.2 1 0 0 1 1 1 0 Mannose-6-phosphate isomerase FAD_binding_1 PF00667.20 EMD66661.1 - 5.5e-49 166.7 0.0 7.9e-49 166.2 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.21 EMD66661.1 - 2.6e-10 40.9 0.0 6.7e-10 39.6 0.0 1.7 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain MOSC PF03473.17 EMD66662.1 - 7.1e-29 100.5 0.0 9.5e-29 100.1 0.0 1.2 1 0 0 1 1 1 1 MOSC domain Allantoicase PF03561.15 EMD66663.1 - 1.7e-94 313.5 0.1 5.2e-49 165.9 0.0 2.0 2 0 0 2 2 2 2 Allantoicase repeat DIL PF01843.19 EMD66664.1 - 4.9e-31 107.1 1.2 9.8e-31 106.1 1.2 1.5 1 0 0 1 1 1 1 DIL domain Ank_2 PF12796.7 EMD66664.1 - 1.6e-15 57.5 0.1 1.9e-14 54.0 0.0 2.7 2 1 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMD66664.1 - 1.2e-11 44.9 0.0 6.7e-06 26.6 0.0 3.9 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 EMD66664.1 - 1.6e-11 44.1 0.0 1e-05 25.8 0.0 3.7 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 EMD66664.1 - 1.8e-09 37.6 0.0 1.6e-08 34.6 0.0 2.4 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMD66664.1 - 3.3e-08 33.2 0.1 0.00043 20.5 0.0 4.2 4 0 0 4 4 4 1 Ankyrin repeat HATPase_c PF02518.26 EMD66665.1 - 1.1e-30 106.4 0.0 2.2e-30 105.5 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 EMD66665.1 - 3.9e-20 71.7 0.0 4e-19 68.4 0.0 2.9 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain Response_reg PF00072.24 EMD66665.1 - 9.5e-18 64.4 0.0 2.3e-17 63.2 0.0 1.7 1 0 0 1 1 1 1 Response regulator receiver domain AAA_16 PF13191.6 EMD66665.1 - 6.8e-11 42.8 0.2 9.3e-10 39.1 0.0 3.0 3 0 0 3 3 3 1 AAA ATPase domain Pkinase PF00069.25 EMD66665.1 - 2.8e-10 40.0 0.0 6.1e-10 38.9 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain GAF_2 PF13185.6 EMD66665.1 - 2.7e-08 34.2 0.0 9.4e-08 32.4 0.0 2.0 1 0 0 1 1 1 1 GAF domain GAF PF01590.26 EMD66665.1 - 5.5e-07 30.3 0.0 1.7e-06 28.7 0.0 1.9 1 0 0 1 1 1 1 GAF domain GAF_3 PF13492.6 EMD66665.1 - 0.00032 21.0 0.0 0.0012 19.1 0.0 2.1 2 0 0 2 2 1 1 GAF domain NACHT PF05729.12 EMD66665.1 - 0.024 14.6 0.6 4.6 7.1 0.1 2.6 2 0 0 2 2 2 0 NACHT domain TPR_19 PF14559.6 EMD66665.1 - 0.041 14.4 0.2 4.8 7.8 0.0 3.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 EMD66665.1 - 0.055 13.8 0.0 0.055 13.8 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat Kinase-like PF14531.6 EMD66665.1 - 0.13 11.5 0.0 0.25 10.6 0.0 1.4 1 0 0 1 1 1 0 Kinase-like Hydrolase_4 PF12146.8 EMD66667.1 - 1.9e-27 96.1 0.0 4.7e-27 94.8 0.0 1.6 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EMD66667.1 - 3.1e-23 82.7 0.0 6.9e-20 71.8 0.0 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EMD66667.1 - 1.7e-17 64.8 0.0 2.9e-17 64.0 0.0 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.16 EMD66667.1 - 9.4e-07 28.8 0.0 0.034 14.0 0.0 3.1 3 0 0 3 3 3 2 Phospholipase/Carboxylesterase Ndr PF03096.14 EMD66667.1 - 4e-06 25.7 0.0 4.5e-06 25.6 0.0 1.3 1 0 0 1 1 1 1 Ndr family Abhydrolase_5 PF12695.7 EMD66667.1 - 6.2e-05 22.8 0.1 0.00089 19.1 0.2 2.5 2 1 0 2 2 2 1 Alpha/beta hydrolase family Chlorophyllase2 PF12740.7 EMD66667.1 - 6.4e-05 22.0 0.1 0.00025 20.0 0.1 1.9 1 1 0 1 1 1 1 Chlorophyllase enzyme Ser_hydrolase PF06821.13 EMD66667.1 - 0.00065 19.6 0.0 0.0071 16.2 0.0 2.1 1 1 1 2 2 2 1 Serine hydrolase PAF-AH_p_II PF03403.13 EMD66667.1 - 0.001 17.6 1.0 0.0054 15.3 0.1 1.9 1 1 1 2 2 2 1 Platelet-activating factor acetylhydrolase, isoform II Thioesterase PF00975.20 EMD66667.1 - 0.0018 18.5 0.0 0.005 17.0 0.0 1.7 2 0 0 2 2 2 1 Thioesterase domain DUF676 PF05057.14 EMD66667.1 - 0.0054 16.3 0.0 0.0085 15.6 0.0 1.3 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Peptidase_S9 PF00326.21 EMD66667.1 - 0.0097 15.4 0.0 1.1 8.7 0.0 2.2 2 0 0 2 2 2 1 Prolyl oligopeptidase family DLH PF01738.18 EMD66667.1 - 0.012 15.2 0.0 1.4 8.4 0.0 2.8 3 0 0 3 3 3 0 Dienelactone hydrolase family Abhydrolase_4 PF08386.10 EMD66667.1 - 0.012 15.7 0.0 0.021 14.9 0.0 1.4 1 0 0 1 1 1 0 TAP-like protein PGAP1 PF07819.13 EMD66667.1 - 0.046 13.4 0.1 0.087 12.5 0.1 1.4 1 0 0 1 1 1 0 PGAP1-like protein Cyt-b5 PF00173.28 EMD66669.1 - 1.6e-18 66.6 0.2 1.8e-18 66.4 0.2 1.0 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Nuclease_act PF08133.11 EMD66669.1 - 0.051 13.7 0.6 0.11 12.7 0.0 1.9 2 0 0 2 2 2 0 Anticodon nuclease activator family TSP9 PF11493.8 EMD66669.1 - 0.094 13.4 0.0 0.11 13.1 0.0 1.1 1 0 0 1 1 1 0 Thylakoid soluble phosphoprotein TSP9 BRX PF08381.11 EMD66669.1 - 0.45 9.9 2.2 4.3 6.8 1.0 2.6 2 1 0 2 2 2 0 Transcription factor regulating root and shoot growth via Pin3 VID27 PF08553.10 EMD66670.1 - 1.2e-191 636.4 0.2 1.6e-191 636.0 0.2 1.2 1 0 0 1 1 1 1 VID27 C-terminal WD40-like domain VID27_N PF17748.1 EMD66670.1 - 1.2e-74 249.8 0.3 1.2e-74 249.8 0.3 2.5 2 0 0 2 2 2 1 VID27 N-terminal region VID27_PH PF17747.1 EMD66670.1 - 8.6e-44 148.3 1.0 3.3e-43 146.4 0.5 2.1 2 0 0 2 2 2 1 VID27 PH-like domain UPF0149 PF03695.13 EMD66670.1 - 0.013 15.8 1.6 0.013 15.8 1.6 1.7 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0149) Dicty_REP PF05086.12 EMD66670.1 - 4 5.3 5.7 6.2 4.7 5.7 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Fungal_trans PF04082.18 EMD66671.1 - 1.4e-10 40.7 2.4 2.6e-10 39.8 2.4 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD66671.1 - 6.6e-07 29.4 9.3 1.5e-06 28.3 9.3 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Cep3 PF16846.5 EMD66671.1 - 0.2 10.1 0.4 0.38 9.2 0.1 1.5 2 0 0 2 2 2 0 Centromere DNA-binding protein complex CBF3 subunit B MFS_1 PF07690.16 EMD66672.1 - 3.6e-41 141.3 29.8 3.6e-41 141.3 29.8 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EMD66672.1 - 1.1e-10 40.6 3.4 1.1e-10 40.6 3.4 1.4 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) MFS_4 PF06779.14 EMD66672.1 - 5.8e-06 25.9 6.4 5.8e-06 25.9 6.4 1.8 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB HECW1_helix PF18436.1 EMD66672.1 - 0.009 16.1 0.0 0.021 14.9 0.0 1.6 1 0 0 1 1 1 1 Helical box domain of E3 ubiquitin-protein ligase HECW1 PGG PF13962.6 EMD66672.1 - 2 8.3 7.6 1.3 8.9 0.2 3.5 3 1 1 4 4 4 0 Domain of unknown function adh_short PF00106.25 EMD66673.1 - 1.8e-38 132.0 0.2 2.5e-38 131.5 0.2 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD66673.1 - 4.6e-28 98.3 0.1 6.8e-28 97.8 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD66673.1 - 4e-08 33.4 1.5 1.1e-06 28.7 1.4 2.2 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 EMD66673.1 - 0.0011 18.5 0.0 0.0018 17.8 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EMD66673.1 - 0.054 13.4 0.0 0.085 12.7 0.0 1.4 1 0 0 1 1 1 0 NAD(P)H-binding UPF0146 PF03686.13 EMD66673.1 - 0.14 12.0 0.0 0.25 11.2 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0146) Macoilin PF09726.9 EMD66674.1 - 0.0051 15.4 22.0 0.0085 14.7 22.0 1.3 1 0 0 1 1 1 1 Macoilin family DUF3106 PF11304.8 EMD66674.1 - 0.0052 17.2 8.6 0.0052 17.2 8.6 4.5 4 2 0 4 4 3 1 Protein of unknown function (DUF3106) ZapB PF06005.12 EMD66674.1 - 0.0057 17.1 33.8 0.44 11.0 15.6 5.1 3 1 1 4 4 3 1 Cell division protein ZapB DUF5082 PF16888.5 EMD66674.1 - 0.023 15.0 18.5 0.79 10.0 12.2 3.2 1 1 1 2 2 2 0 Domain of unknown function (DUF5082) DASH_Dam1 PF08653.10 EMD66674.1 - 0.024 14.4 0.4 0.12 12.2 0.4 2.2 1 0 0 1 1 1 0 DASH complex subunit Dam1 RPW8 PF05659.11 EMD66674.1 - 0.048 13.4 6.1 1.1 8.9 0.1 3.2 4 0 0 4 4 4 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 Spc29 PF17082.5 EMD66674.1 - 0.13 12.1 16.4 0.12 12.3 7.0 2.5 1 1 1 2 2 2 0 Spindle Pole Component 29 UPF0242 PF06785.11 EMD66674.1 - 0.19 11.8 29.6 33 4.5 29.2 2.4 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF3584 PF12128.8 EMD66674.1 - 0.2 9.1 30.4 0.3 8.6 30.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) CotJB PF12652.7 EMD66674.1 - 0.38 11.0 2.0 0.78 10.0 0.7 2.1 1 1 1 2 2 2 0 CotJB protein CENP-H PF05837.12 EMD66674.1 - 0.38 11.2 23.9 11 6.4 8.3 3.4 1 1 1 2 2 2 0 Centromere protein H (CENP-H) Bacillus_HBL PF05791.11 EMD66674.1 - 1.1 9.0 15.0 1.1 9.0 1.5 2.8 2 1 1 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) GPS2_interact PF15784.5 EMD66674.1 - 1.2 9.6 11.9 0.12 12.9 5.6 2.4 2 1 0 2 2 2 0 G-protein pathway suppressor 2-interacting domain Gp-FAR-1 PF05823.12 EMD66674.1 - 1.8 8.9 8.7 1.9 8.8 5.7 2.5 1 1 1 2 2 2 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) DivIC PF04977.15 EMD66674.1 - 2 8.3 29.0 0.055 13.3 1.1 4.7 2 1 2 4 4 4 0 Septum formation initiator bZIP_1 PF00170.21 EMD66674.1 - 2.1 8.5 19.2 4.9 7.3 2.3 4.6 2 1 3 5 5 5 0 bZIP transcription factor HMMR_N PF15905.5 EMD66674.1 - 2.2 7.7 30.5 34 3.8 7.2 2.6 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor N-terminal DUF4201 PF13870.6 EMD66674.1 - 2.8 7.6 25.3 4.6 6.9 7.8 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) DUF4407 PF14362.6 EMD66674.1 - 2.9 7.1 34.8 0.95 8.8 22.5 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) HIP1_clath_bdg PF16515.5 EMD66674.1 - 3.4 8.3 32.1 0.055 14.1 7.1 3.8 2 1 2 4 4 4 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Muted PF14942.6 EMD66674.1 - 3.8 7.8 22.0 2.9 8.3 11.5 2.8 2 0 0 2 2 2 0 Organelle biogenesis, Muted-like protein Spc7 PF08317.11 EMD66674.1 - 4.1 6.2 32.4 9.1 5.1 17.2 2.5 1 1 1 2 2 2 0 Spc7 kinetochore protein Rod_cone_degen PF15201.6 EMD66675.1 - 3.2 7.9 7.3 0.66 10.1 1.7 3.0 2 0 0 2 2 2 0 Progressive rod-cone degeneration CSTF2_hinge PF14327.6 EMD66676.1 - 1.2e-32 112.2 2.9 1.2e-32 112.2 2.9 2.1 2 0 0 2 2 2 1 Hinge domain of cleavage stimulation factor subunit 2 RRM_1 PF00076.22 EMD66676.1 - 4.1e-19 68.2 0.0 6.7e-19 67.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CSTF_C PF14304.6 EMD66676.1 - 2.1e-07 30.4 7.7 2.1e-07 30.4 7.7 2.6 3 0 0 3 3 3 1 Transcription termination and cleavage factor C-terminal Cu_amine_oxid PF01179.20 EMD66677.1 - 2.2e-160 534.1 0.0 2.7e-160 533.8 0.0 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN2 PF02727.16 EMD66677.1 - 2.2e-13 50.3 0.1 4.2e-13 49.3 0.1 1.5 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain Cu_amine_oxidN3 PF02728.16 EMD66677.1 - 0.0018 18.7 0.0 0.0063 16.9 0.0 1.9 2 0 0 2 2 2 1 Copper amine oxidase, N3 domain Glyco_hydro_61 PF03443.14 EMD66678.1 - 9.6e-49 166.1 0.1 1.2e-48 165.8 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 ABC2_membrane PF01061.24 EMD66680.1 - 2.2e-46 157.9 34.5 1.5e-25 89.9 15.0 2.3 2 0 0 2 2 2 2 ABC-2 type transporter ABC_tran PF00005.27 EMD66680.1 - 1.2e-35 123.0 0.1 1.2e-21 77.7 0.0 2.5 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 EMD66680.1 - 7.6e-08 32.5 1.2 0.039 13.7 0.0 3.3 3 0 0 3 3 3 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EMD66680.1 - 1.7e-06 27.7 0.0 0.0013 18.2 0.0 2.8 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 EMD66680.1 - 2.4e-05 24.3 0.0 4.6e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_16 PF13191.6 EMD66680.1 - 0.00062 20.2 0.0 0.0015 19.0 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_23 PF13476.6 EMD66680.1 - 0.0017 18.9 0.0 0.0031 18.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EMD66680.1 - 0.0032 17.8 0.0 0.015 15.6 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 EMD66680.1 - 0.0056 16.7 0.0 0.025 14.6 0.0 2.0 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_29 PF13555.6 EMD66680.1 - 0.0077 16.0 0.0 0.019 14.7 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain ATPase_2 PF01637.18 EMD66680.1 - 0.0084 16.0 0.0 0.015 15.2 0.0 1.3 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea SbcCD_C PF13558.6 EMD66680.1 - 0.0099 16.1 0.3 17 5.7 0.1 3.6 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit NACHT PF05729.12 EMD66680.1 - 0.021 14.7 0.0 0.047 13.6 0.0 1.6 1 0 0 1 1 1 0 NACHT domain AAA_25 PF13481.6 EMD66680.1 - 0.029 13.9 0.0 0.13 11.8 0.0 2.1 1 0 0 1 1 1 0 AAA domain PDR_assoc PF08370.11 EMD66680.1 - 0.048 13.4 0.9 0.36 10.6 0.9 2.6 1 0 0 1 1 1 0 Plant PDR ABC transporter associated Cytidylate_kin PF02224.18 EMD66680.1 - 0.18 11.5 0.1 0.62 9.8 0.0 1.8 2 0 0 2 2 2 0 Cytidylate kinase cobW PF02492.19 EMD66680.1 - 0.19 11.3 0.0 0.34 10.5 0.0 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain RNA_helicase PF00910.22 EMD66680.1 - 0.19 12.1 0.1 0.69 10.3 0.1 1.9 2 0 0 2 2 1 0 RNA helicase Fungal_trans_2 PF11951.8 EMD66682.1 - 1.4e-53 182.1 0.0 2e-53 181.6 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD66682.1 - 3.7e-09 36.5 11.9 6.4e-09 35.8 11.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Lactamase_B_6 PF16661.5 EMD66683.1 - 3.4e-66 222.4 0.0 5e-66 221.8 0.0 1.2 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain CPSF100_C PF13299.6 EMD66683.1 - 4.2e-46 157.2 3.3 5e-46 157.0 0.0 2.3 2 0 0 2 2 2 1 Cleavage and polyadenylation factor 2 C-terminal Beta-Casp PF10996.8 EMD66683.1 - 6.8e-21 74.6 0.0 6.1e-20 71.6 0.0 2.5 2 1 1 3 3 3 1 Beta-Casp domain RMMBL PF07521.12 EMD66683.1 - 3.6e-12 46.0 0.0 7e-12 45.1 0.0 1.5 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain TamB PF04357.13 EMD66683.1 - 0.022 14.0 0.0 0.038 13.2 0.0 1.3 1 0 0 1 1 1 0 TamB, inner membrane protein subunit of TAM complex Lactamase_B PF00753.27 EMD66683.1 - 0.032 14.2 0.1 0.13 12.2 0.0 2.1 2 0 0 2 2 2 0 Metallo-beta-lactamase superfamily CDC37_N PF03234.14 EMD66684.1 - 2.1e-48 164.5 3.2 2.1e-48 164.5 3.2 2.8 2 0 0 2 2 2 1 Cdc37 N terminal kinase binding CDC37_M PF08565.11 EMD66684.1 - 1.1e-45 154.4 0.8 3.9e-45 152.6 0.0 2.3 2 0 0 2 2 2 1 Cdc37 Hsp90 binding domain CDC37_C PF08564.10 EMD66684.1 - 2.2e-30 104.8 0.9 2.2e-30 104.8 0.9 2.3 2 0 0 2 2 2 1 Cdc37 C terminal domain V-ATPase_H_N PF03224.14 EMD66684.1 - 0.04 13.2 0.1 0.077 12.3 0.1 1.4 1 0 0 1 1 1 0 V-ATPase subunit H CTD_bind PF04818.13 EMD66685.1 - 1.3e-15 58.0 0.1 3.7e-15 56.5 0.1 1.9 1 0 0 1 1 1 1 RNA polymerase II-binding domain. CREPT PF16566.5 EMD66685.1 - 0.00017 21.8 0.7 0.00017 21.8 0.7 2.1 2 0 0 2 2 2 1 Cell-cycle alteration and expression-elevated protein in tumour NACHT_N PF17100.5 EMD66685.1 - 0.71 9.7 4.6 4.1 7.2 0.8 2.3 2 0 0 2 2 2 0 N-terminal domain of NWD NACHT-NTPase Allexi_40kDa PF05549.11 EMD66685.1 - 1 8.8 3.4 16 4.9 0.2 2.4 2 0 0 2 2 2 0 Allexivirus 40kDa protein AAA_13 PF13166.6 EMD66685.1 - 4.6 5.7 8.8 4.1 5.9 0.2 2.1 2 0 0 2 2 2 0 AAA domain Clathrin_lg_ch PF01086.17 EMD66686.1 - 1.6e-81 273.8 4.3 1.8e-81 273.6 4.3 1.0 1 0 0 1 1 1 1 Clathrin light chain rve_3 PF13683.6 EMD66686.1 - 0.05 13.4 1.1 0.11 12.4 1.1 1.5 1 0 0 1 1 1 0 Integrase core domain CdiI_2 PF18593.1 EMD66686.1 - 0.12 13.1 0.6 0.7 10.6 0.1 2.3 2 0 0 2 2 2 0 CdiI immunity protein Glyco_hydro_61 PF03443.14 EMD66687.1 - 1.3e-62 211.4 0.2 1.5e-62 211.2 0.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 AA_permease_2 PF13520.6 EMD66689.1 - 2.1e-59 201.4 53.4 2.6e-59 201.2 53.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EMD66689.1 - 3.9e-15 55.4 53.4 7e-15 54.6 53.4 1.3 1 1 0 1 1 1 1 Amino acid permease Presenilin PF01080.17 EMD66689.1 - 0.98 8.1 7.6 0.052 12.3 1.0 2.1 2 0 0 2 2 2 0 Presenilin SLATT_1 PF18181.1 EMD66689.1 - 5 7.1 13.2 0.13 12.1 0.5 3.5 2 1 1 3 3 3 0 SMODS and SLOG-associating 2TM effector domain 1 Glyco_transf_20 PF00982.21 EMD66691.1 - 1.9e-148 495.1 0.0 2.5e-148 494.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 EMD66691.1 - 1.9e-85 285.7 0.0 3.2e-85 285.0 0.0 1.4 1 0 0 1 1 1 1 Trehalose-phosphatase Hydrolase_3 PF08282.12 EMD66691.1 - 0.0021 17.8 0.0 0.051 13.3 0.0 2.3 1 1 1 2 2 2 1 haloacid dehalogenase-like hydrolase PAP_assoc PF03828.19 EMD66692.1 - 2e-05 24.7 0.0 4.3e-05 23.6 0.0 1.6 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 EMD66692.1 - 0.00018 21.7 0.0 0.00064 20.0 0.0 2.0 1 0 0 1 1 1 1 Nucleotidyltransferase domain THB PF18362.1 EMD66692.1 - 0.017 14.7 0.1 0.039 13.6 0.1 1.6 1 0 0 1 1 1 0 Tri-helix bundle domain DNA_pol_B_palm PF14792.6 EMD66692.1 - 0.027 14.6 0.0 0.09 13.0 0.0 1.9 1 0 0 1 1 1 0 DNA polymerase beta palm Polbeta PF18765.1 EMD66692.1 - 0.28 11.3 1.8 4.3 7.5 0.0 2.7 2 1 1 3 3 3 0 Polymerase beta, Nucleotidyltransferase UQ_con PF00179.26 EMD66693.1 - 1.1e-52 177.4 0.0 1.2e-52 177.2 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EMD66693.1 - 0.005 16.5 0.0 0.0061 16.3 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 EMD66693.1 - 0.035 14.4 0.0 0.045 14.0 0.0 1.3 1 0 0 1 1 1 0 RWD domain UEV PF05743.13 EMD66693.1 - 0.046 13.6 0.0 0.072 13.0 0.0 1.3 1 0 0 1 1 1 0 UEV domain Acyl-CoA_dh_N PF02771.16 EMD66694.1 - 1.4e-23 83.7 0.3 2.8e-23 82.7 0.3 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_1 PF00441.24 EMD66694.1 - 6.8e-23 81.5 0.2 1.1e-22 80.8 0.2 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 EMD66694.1 - 1.6e-16 60.3 0.0 2.8e-16 59.5 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 EMD66694.1 - 2e-05 24.9 0.3 3.7e-05 24.0 0.3 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain XPG_I PF00867.18 EMD66695.1 - 7.5e-31 106.3 1.8 1.8e-30 105.1 0.0 2.3 2 0 0 2 2 2 1 XPG I-region XPG_N PF00752.17 EMD66695.1 - 1.7e-30 105.5 0.0 5.9e-30 103.7 0.0 2.0 1 0 0 1 1 1 1 XPG N-terminal domain 5_3_exonuc PF01367.20 EMD66695.1 - 2e-07 31.5 0.6 1.5e-06 28.7 0.0 2.5 2 0 0 2 2 2 1 5'-3' exonuclease, C-terminal SAM fold HHH_5 PF14520.6 EMD66695.1 - 0.045 14.4 0.0 0.13 12.9 0.0 1.8 1 0 0 1 1 1 0 Helix-hairpin-helix domain DUF3671 PF12420.8 EMD66696.1 - 0.006 16.6 2.0 0.0068 16.5 2.0 1.0 1 0 0 1 1 1 1 Protein of unknown function BRCT_2 PF16589.5 EMD66698.1 - 4.7e-11 43.0 0.0 7.7e-11 42.3 0.0 1.4 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 EMD66698.1 - 0.077 13.4 0.0 0.15 12.4 0.0 1.5 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain DUF3583 PF12126.8 EMD66699.1 - 0.097 12.1 0.1 0.17 11.3 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3583) PhzC-PhzF PF02567.16 EMD66701.1 - 6.7e-40 137.3 0.1 8.3e-40 137.0 0.1 1.1 1 0 0 1 1 1 1 Phenazine biosynthesis-like protein DUF5310 PF17237.2 EMD66703.1 - 4.6e-20 71.2 1.3 5.3e-20 71.0 1.3 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5310) Adaptin_N PF01602.20 EMD66704.1 - 6.1e-136 454.0 7.4 7.8e-136 453.7 7.4 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EMD66704.1 - 7.3e-62 208.2 7.2 2.7e-58 196.6 0.5 2.8 3 0 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EMD66704.1 - 1.6e-14 54.0 7.6 7.5e-06 26.3 0.1 5.5 4 2 4 8 8 8 5 HEAT repeats HEAT PF02985.22 EMD66704.1 - 1.1e-10 40.8 8.3 0.011 15.9 0.0 7.0 8 0 0 8 8 8 3 HEAT repeat UNC45-central PF11701.8 EMD66704.1 - 0.00015 21.8 0.4 0.095 12.7 0.1 3.0 2 1 0 2 2 2 2 Myosin-binding striated muscle assembly central CLASP_N PF12348.8 EMD66704.1 - 0.00015 21.4 0.1 0.68 9.4 0.0 3.6 2 1 1 3 3 3 2 CLASP N terminal Arm PF00514.23 EMD66704.1 - 0.0026 17.8 1.9 37 4.6 0.0 5.5 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat Sec7_N PF12783.7 EMD66704.1 - 0.013 15.4 1.0 0.052 13.4 0.2 2.5 3 0 0 3 3 3 0 Guanine nucleotide exchange factor in Golgi transport N-terminal HEAT_EZ PF13513.6 EMD66704.1 - 0.063 13.8 3.4 15 6.2 0.0 5.2 5 0 0 5 5 5 0 HEAT-like repeat CAAP1 PF15335.6 EMD66704.1 - 0.48 11.0 0.1 0.48 11.0 0.1 2.6 3 0 0 3 3 3 0 Caspase activity and apoptosis inhibitor 1 PAP2_3 PF14378.6 EMD66705.1 - 2.1e-22 79.7 17.3 2.1e-22 79.7 17.3 2.3 1 1 1 2 2 2 1 PAP2 superfamily PAP2 PF01569.21 EMD66705.1 - 3e-07 30.3 4.9 3e-07 30.3 4.9 2.4 2 1 0 2 2 2 1 PAP2 superfamily Mito_carr PF00153.27 EMD66707.1 - 5.5e-47 157.6 4.4 6.6e-18 64.4 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein RRM_1 PF00076.22 EMD66708.1 - 1.1e-52 175.7 0.0 1.3e-16 60.2 0.0 3.5 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EMD66708.1 - 5.3e-05 22.8 0.0 0.013 15.1 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 EMD66708.1 - 0.00033 20.7 0.0 1.8 8.7 0.0 3.5 3 1 0 3 3 3 2 Limkain b1 RRM_occluded PF16842.5 EMD66708.1 - 0.018 14.9 0.0 17 5.3 0.0 3.1 3 0 0 3 3 3 0 Occluded RNA-recognition motif PknH_C PF14032.6 EMD66708.1 - 0.04 13.8 0.1 7 6.5 0.0 3.1 3 0 0 3 3 3 0 PknH-like extracellular domain ATP-grasp_2 PF08442.10 EMD66708.1 - 0.077 12.6 0.0 1 8.9 0.0 2.5 3 0 0 3 3 3 0 ATP-grasp domain YoaP PF14268.6 EMD66708.1 - 0.43 10.1 3.7 2.9 7.5 0.0 2.8 3 0 0 3 3 3 0 YoaP-like THRAP3_BCLAF1 PF15440.6 EMD66708.1 - 0.73 8.8 26.5 0.97 8.4 26.5 1.1 1 0 0 1 1 1 0 THRAP3/BCLAF1 family AMP-binding PF00501.28 EMD66709.1 - 1.6e-94 316.9 0.0 1.9e-94 316.7 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EMD66709.1 - 1.6e-12 48.2 2.1 3.3e-12 47.2 2.1 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain zf-CCCH PF00642.24 EMD66710.1 - 4.1e-09 36.1 10.8 3.6e-05 23.6 2.3 2.4 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 EMD66710.1 - 9.3e-09 34.9 10.1 6.4e-06 25.8 2.4 2.4 2 0 0 2 2 2 2 CCCH-type zinc finger Torus PF16131.5 EMD66710.1 - 2.5e-08 34.6 6.7 0.00016 22.3 0.5 2.5 1 1 1 2 2 2 2 Torus domain zf_CCCH_4 PF18345.1 EMD66710.1 - 4.4e-07 29.7 19.3 0.00048 20.1 3.6 2.4 2 0 0 2 2 2 2 Zinc finger domain zf-CCCH_3 PF15663.5 EMD66710.1 - 6e-05 23.2 1.5 0.00016 21.9 1.6 1.6 2 0 0 2 2 2 1 Zinc-finger containing family zf-CCCH_2 PF14608.6 EMD66710.1 - 0.3 11.6 13.5 0.94 10.1 2.4 2.6 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger PNISR PF15996.5 EMD66711.1 - 0.25 11.6 3.5 0.3 11.4 3.5 1.1 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR ANAPC4_WD40 PF12894.7 EMD66712.1 - 7.5e-09 35.8 0.2 0.0014 18.9 0.0 4.7 5 1 1 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EMD66712.1 - 0.00082 20.1 0.1 12 7.0 0.0 4.9 5 0 0 5 5 5 1 WD domain, G-beta repeat PD40 PF07676.12 EMD66712.1 - 0.079 12.9 0.0 15 5.7 0.0 2.7 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat Acetyltransf_1 PF00583.25 EMD66713.1 - 1.4e-06 28.6 0.0 2.9e-06 27.5 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EMD66713.1 - 5.2e-06 26.4 0.0 8.5e-06 25.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EMD66713.1 - 1.9e-05 25.0 0.0 3.1e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EMD66713.1 - 0.007 16.4 0.0 0.33 11.0 0.0 2.3 2 1 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EMD66713.1 - 0.016 15.2 0.0 0.032 14.2 0.0 1.5 1 0 0 1 1 1 0 FR47-like protein Elongin_A PF06881.11 EMD66714.1 - 1e-33 115.9 1.9 1.8e-33 115.2 1.9 1.4 1 0 0 1 1 1 1 RNA polymerase II transcription factor SIII (Elongin) subunit A Exonuc_V_gamma PF04257.14 EMD66714.1 - 0.06 11.6 0.2 0.086 11.0 0.2 1.2 1 0 0 1 1 1 0 Exodeoxyribonuclease V, gamma subunit THOC7 PF05615.13 EMD66715.1 - 3.4e-26 92.1 7.6 3.4e-26 92.1 7.6 2.2 1 1 1 2 2 2 1 Tho complex subunit 7 CALCOCO1 PF07888.11 EMD66715.1 - 1.6e-05 24.0 18.8 2.5e-05 23.4 18.8 1.2 1 0 0 1 1 1 1 Calcium binding and coiled-coil domain (CALCOCO1) like DivIC PF04977.15 EMD66715.1 - 0.004 16.9 1.3 0.004 16.9 1.3 3.3 2 1 1 3 3 3 1 Septum formation initiator FlaC_arch PF05377.11 EMD66715.1 - 0.67 10.4 3.6 3 8.3 0.4 2.7 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) TBCA PF02970.16 EMD66716.1 - 4.3e-26 91.1 11.5 5.3e-26 90.8 11.5 1.2 1 0 0 1 1 1 1 Tubulin binding cofactor A DUF1542 PF07564.11 EMD66716.1 - 0.0038 17.3 2.9 0.0038 17.3 2.9 2.2 2 1 0 2 2 2 1 Domain of Unknown Function (DUF1542) DUF874 PF05917.11 EMD66716.1 - 0.029 13.4 7.2 0.034 13.2 7.2 1.0 1 0 0 1 1 1 0 Helicobacter pylori protein of unknown function (DUF874) FapA PF03961.13 EMD66716.1 - 0.043 12.4 7.3 0.048 12.3 7.3 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF4407 PF14362.6 EMD66716.1 - 0.063 12.6 7.2 0.076 12.4 7.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Calpain_inhib PF00748.19 EMD66716.1 - 0.39 11.2 9.9 0.48 10.9 9.9 1.2 1 0 0 1 1 1 0 Calpain inhibitor DUF2570 PF10828.8 EMD66716.1 - 0.5 10.2 7.5 1.3 8.9 7.4 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF2570) Spc7 PF08317.11 EMD66716.1 - 0.62 8.9 13.9 2.7 6.8 13.9 1.8 1 1 0 1 1 1 0 Spc7 kinetochore protein V_ATPase_I PF01496.19 EMD66716.1 - 0.66 7.8 6.9 0.68 7.8 6.9 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF1910 PF08928.10 EMD66716.1 - 2.9 7.9 7.4 1.2 9.2 2.8 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF1910) Tho2 PF11262.8 EMD66716.1 - 5.5 6.1 7.5 7.2 5.7 7.5 1.1 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 MCM PF00493.23 EMD66717.1 - 3e-100 333.9 0.0 4.4e-100 333.4 0.0 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EMD66717.1 - 1.7e-37 128.1 1.0 3.6e-37 127.0 1.0 1.5 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EMD66717.1 - 2.6e-29 101.5 1.7 6.3e-29 100.2 1.7 1.7 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 EMD66717.1 - 4.4e-15 56.2 0.0 1.6e-14 54.3 0.0 2.1 2 0 0 2 2 2 1 MCM N-terminal domain AAA_5 PF07728.14 EMD66717.1 - 5.1e-06 26.5 0.1 2.4e-05 24.3 0.0 2.2 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 EMD66717.1 - 1.1e-05 25.0 0.0 0.00024 20.5 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 EMD66717.1 - 0.0003 20.6 0.0 0.0011 18.8 0.0 2.0 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EMD66717.1 - 0.074 12.8 0.1 2.5 7.8 0.0 2.8 3 0 0 3 3 3 0 Sigma-54 interaction domain Elf1 PF05129.13 EMD66717.1 - 0.13 12.3 0.4 0.32 11.0 0.4 1.6 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like CBM-like PF14683.6 EMD66718.1 - 1.4e-37 129.2 0.1 3.2e-37 127.9 0.0 1.7 2 0 0 2 2 2 1 Polysaccharide lyase family 4, domain III fn3_3 PF14686.6 EMD66718.1 - 5.5e-15 54.9 0.5 1.6e-14 53.5 0.5 1.9 1 0 0 1 1 1 1 Polysaccharide lyase family 4, domain II CarboxypepD_reg PF13620.6 EMD66718.1 - 8.4e-07 29.2 0.3 7.7e-06 26.1 0.2 2.6 2 0 0 2 2 2 1 Carboxypeptidase regulatory-like domain DUF2012 PF09430.10 EMD66718.1 - 0.011 15.8 0.0 0.03 14.5 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2012) CarbopepD_reg_2 PF13715.6 EMD66718.1 - 0.092 12.8 0.0 5.8 7.0 0.0 2.9 2 1 0 2 2 2 0 CarboxypepD_reg-like domain Vac7 PF12751.7 EMD66719.1 - 8.5e-111 371.1 12.9 3.3e-99 332.9 3.1 3.9 4 0 0 4 4 4 2 Vacuolar segregation subunit 7 SSF PF00474.17 EMD66724.1 - 9.3e-18 64.3 30.6 1.6e-17 63.5 30.6 1.4 1 0 0 1 1 1 1 Sodium:solute symporter family DEAD PF00270.29 EMD66726.1 - 1.2e-36 126.1 0.3 2e-36 125.4 0.3 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EMD66726.1 - 1.4e-30 105.9 0.6 7.7e-29 100.3 0.0 2.6 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EMD66726.1 - 1.5e-05 25.1 0.0 5.7e-05 23.2 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 EMD66726.1 - 0.00023 21.5 0.2 0.00081 19.7 0.2 1.9 1 1 0 1 1 1 1 AAA domain Flavi_DEAD PF07652.14 EMD66726.1 - 0.0007 19.6 0.1 0.0014 18.6 0.1 1.5 1 0 0 1 1 1 1 Flavivirus DEAD domain PAP2 PF01569.21 EMD66727.1 - 0.068 12.9 0.1 0.11 12.3 0.1 1.3 1 0 0 1 1 1 0 PAP2 superfamily PEX-1N PF09262.11 EMD66728.1 - 0.09 13.2 0.1 0.25 11.8 0.1 1.8 1 0 0 1 1 1 0 Peroxisome biogenesis factor 1, N-terminal HET PF06985.11 EMD66729.1 - 1.4e-12 48.2 7.2 4.5e-10 40.1 1.6 2.2 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) AMP-binding PF00501.28 EMD66731.1 - 3.4e-93 312.5 0.0 4.8e-93 312.1 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme RabGAP-TBC PF00566.18 EMD66731.1 - 1.2e-47 162.4 0.1 1.9e-47 161.7 0.1 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain AMP-binding_C PF13193.6 EMD66731.1 - 2.8e-20 73.0 0.2 7.8e-20 71.6 0.2 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain EF-hand_6 PF13405.6 EMD66731.1 - 1.5e-05 24.5 1.1 0.024 14.6 0.3 4.1 3 0 0 3 3 3 1 EF-hand domain DUF1967 PF09269.11 EMD66731.1 - 0.0053 16.7 0.0 0.16 11.9 0.0 3.0 3 0 0 3 3 3 1 Domain of unknown function (DUF1967) EF-hand_5 PF13202.6 EMD66731.1 - 0.013 15.0 0.4 0.22 11.1 0.3 2.7 2 0 0 2 2 2 0 EF hand EF-hand_7 PF13499.6 EMD66731.1 - 0.041 14.3 4.0 0.17 12.4 0.6 3.6 3 1 1 4 4 4 0 EF-hand domain pair GRAM PF02893.20 EMD66731.1 - 0.076 12.9 0.0 0.16 11.8 0.0 1.5 1 0 0 1 1 1 0 GRAM domain EF-hand_1 PF00036.32 EMD66731.1 - 0.29 10.8 11.2 0.13 11.8 0.8 4.5 6 0 0 6 6 6 0 EF hand adh_short_C2 PF13561.6 EMD66732.1 - 2.6e-54 184.3 0.1 3.7e-54 183.8 0.1 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EMD66732.1 - 5.8e-42 143.4 0.2 8.2e-42 142.9 0.2 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EMD66732.1 - 5.6e-13 49.2 0.1 1e-12 48.4 0.1 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EMD66732.1 - 0.002 17.6 0.1 0.0038 16.7 0.1 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EMD66732.1 - 0.015 14.7 0.0 4.5 6.6 0.0 2.1 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase 3HCDH_N PF02737.18 EMD66732.1 - 0.02 14.8 0.1 0.041 13.8 0.1 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Exo_endo_phos PF03372.23 EMD66733.1 - 0.0039 16.7 0.0 0.0059 16.2 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF4658 PF15555.6 EMD66734.1 - 0.21 11.7 0.0 0.3 11.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4658) adh_short PF00106.25 EMD66737.1 - 1.3e-42 145.5 0.0 1.7e-42 145.1 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD66737.1 - 7.7e-33 114.0 0.0 9.9e-33 113.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD66737.1 - 7.6e-06 25.9 0.2 2.6e-05 24.2 0.2 2.0 1 1 0 1 1 1 1 KR domain CoA_transf_3 PF02515.17 EMD66737.1 - 0.0042 16.3 0.0 0.012 14.8 0.0 1.7 1 1 0 2 2 2 1 CoA-transferase family III ADH_zinc_N PF00107.26 EMD66737.1 - 0.014 15.4 0.0 0.024 14.6 0.0 1.4 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Epimerase PF01370.21 EMD66737.1 - 0.029 13.8 0.0 0.044 13.3 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EMD66737.1 - 0.13 11.7 0.0 0.19 11.1 0.0 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Lipase_3 PF01764.25 EMD66740.1 - 2.3e-05 24.3 0.0 4.9e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_5 PF12695.7 EMD66740.1 - 0.00047 20.0 0.0 0.00084 19.1 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family UPF0227 PF05728.12 EMD66740.1 - 0.12 12.3 0.0 0.19 11.6 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) PGAP1 PF07819.13 EMD66740.1 - 0.14 11.8 0.1 0.37 10.5 0.1 1.6 1 1 0 1 1 1 0 PGAP1-like protein DUF3487 PF11990.8 EMD66741.1 - 1.9 8.4 8.7 4.9 7.1 0.1 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF3487) Ank_2 PF12796.7 EMD66742.1 - 8.8e-17 61.5 9.5 3.1e-08 34.1 0.6 3.3 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMD66742.1 - 6.8e-13 48.9 5.0 0.011 16.3 0.2 5.5 3 2 3 6 6 6 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMD66742.1 - 2.3e-11 42.8 8.2 0.099 13.3 0.1 6.4 6 0 0 6 6 6 4 Ankyrin repeat Ank_5 PF13857.6 EMD66742.1 - 2.8e-09 37.1 5.9 0.084 13.2 0.0 4.8 4 1 1 5 5 5 3 Ankyrin repeats (many copies) Ank PF00023.30 EMD66742.1 - 1.8e-07 31.3 12.3 0.027 14.9 0.5 5.6 5 0 0 5 5 5 2 Ankyrin repeat Nop14 PF04147.12 EMD66742.1 - 0.06 11.6 3.9 0.074 11.3 3.9 1.1 1 0 0 1 1 1 0 Nop14-like family Fer2_4 PF13510.6 EMD66742.1 - 0.21 11.6 0.6 9 6.4 0.1 2.9 2 0 0 2 2 2 0 2Fe-2S iron-sulfur cluster binding domain CDC45 PF02724.14 EMD66742.1 - 0.29 9.4 6.4 0.38 9.0 6.4 1.1 1 0 0 1 1 1 0 CDC45-like protein NOA36 PF06524.12 EMD66742.1 - 2.9 7.1 6.7 4.6 6.5 6.7 1.3 1 0 0 1 1 1 0 NOA36 protein Lipase_GDSL_2 PF13472.6 EMD66743.1 - 2.5e-13 50.8 0.7 3.5e-13 50.3 0.7 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EMD66743.1 - 1.7e-07 31.4 0.2 2.7e-07 30.8 0.2 1.3 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase DUF4149 PF13664.6 EMD66744.1 - 1.1e-20 73.9 1.3 1.1e-20 73.9 1.3 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4149) Zn_clus PF00172.18 EMD66745.1 - 0.0012 18.9 11.1 0.0021 18.1 11.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Glyco_hydro_64 PF16483.5 EMD66746.1 - 6.6e-138 460.0 0.1 7.8e-138 459.8 0.1 1.1 1 0 0 1 1 1 1 Beta-1,3-glucanase DUF2502 PF10697.9 EMD66746.1 - 0.014 15.8 0.1 0.04 14.3 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2502) OGFr_III PF04680.13 EMD66746.1 - 2.5 8.8 10.0 2.2 9.0 7.6 2.2 2 0 0 2 2 2 0 Opioid growth factor receptor repeat DUF4106 PF13388.6 EMD66746.1 - 3.4 6.8 7.6 5.6 6.1 7.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4106) DUF4298 PF14131.6 EMD66747.1 - 0.038 13.9 1.1 0.11 12.4 0.3 2.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4298) RPW8 PF05659.11 EMD66747.1 - 0.11 12.2 1.6 0.47 10.2 0.3 2.2 2 0 0 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 Fungal_trans PF04082.18 EMD66748.1 - 1.5e-09 37.3 0.0 2.5e-09 36.5 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD66748.1 - 1.3e-08 34.8 7.9 2.7e-08 33.8 7.9 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain IDO PF01231.18 EMD66749.1 - 3.4e-147 490.7 0.0 4e-147 490.5 0.0 1.0 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase Aminotran_5 PF00266.19 EMD66750.1 - 1.8e-07 30.5 0.0 3e-07 29.7 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class-V PHD PF00628.29 EMD66752.1 - 1e-09 38.1 1.4 2.3e-09 37.0 1.4 1.6 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 EMD66752.1 - 0.025 14.1 2.4 0.044 13.3 2.4 1.4 1 0 0 1 1 1 0 PHD-finger PNTB PF02233.16 EMD66753.1 - 3.7e-173 576.7 26.7 3.7e-173 576.7 26.7 2.1 2 0 0 2 2 2 1 NAD(P) transhydrogenase beta subunit AlaDh_PNT_C PF01262.21 EMD66753.1 - 5.6e-73 244.8 0.2 1.5e-72 243.4 0.2 1.8 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain AlaDh_PNT_N PF05222.15 EMD66753.1 - 2.1e-44 151.1 0.2 5.1e-44 149.9 0.2 1.7 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain PNTB_4TM PF12769.7 EMD66753.1 - 6.8e-30 103.4 2.7 6.8e-30 103.4 2.7 4.7 4 1 0 4 4 4 1 4TM region of pyridine nucleotide transhydrogenase, mitoch 2-Hacid_dh_C PF02826.19 EMD66753.1 - 0.0037 16.6 0.3 0.66 9.3 0.1 2.9 3 0 0 3 3 3 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TPP_enzyme_M PF00205.22 EMD66753.1 - 0.0038 17.0 0.6 0.026 14.3 0.4 2.6 2 1 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain Pyr_redox_2 PF07992.14 EMD66753.1 - 0.02 14.2 0.3 0.056 12.7 0.3 1.8 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Fumerase PF05681.14 EMD66753.1 - 0.058 12.8 0.1 0.11 12.0 0.1 1.3 1 0 0 1 1 1 0 Fumarate hydratase (Fumerase) GIDA PF01134.22 EMD66753.1 - 0.11 11.6 1.3 0.2 10.7 1.3 1.4 1 0 0 1 1 1 0 Glucose inhibited division protein A Peptidase_M17_N PF02789.17 EMD66753.1 - 0.8 9.6 3.6 3 7.7 0.3 2.6 2 0 0 2 2 2 0 Cytosol aminopeptidase family, N-terminal domain NAD_binding_8 PF13450.6 EMD66753.1 - 1.2 9.4 5.2 0.34 11.2 0.8 2.5 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain PAN_4 PF14295.6 EMD66754.1 - 0.034 14.0 3.3 0.071 13.0 1.6 2.5 2 0 0 2 2 2 0 PAN domain DUF1727 PF08353.10 EMD66754.1 - 0.051 13.5 0.0 0.094 12.6 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1727) DUF4360 PF14273.6 EMD66755.1 - 8.7e-65 217.9 3.0 1e-64 217.7 3.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4360) DUF4141 PF13605.6 EMD66755.1 - 5.3 6.3 5.7 1.8 7.9 0.8 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4141) Velvet PF11754.8 EMD66756.1 - 5.7e-06 26.5 0.2 1.2e-05 25.4 0.2 1.7 1 1 0 1 1 1 1 Velvet factor tRNA-synt_1d PF00750.19 EMD66757.1 - 5e-98 328.3 9.3 1.2e-96 323.7 9.3 2.0 1 1 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.15 EMD66757.1 - 1.4e-28 99.5 0.5 1.4e-28 99.5 0.5 2.1 2 0 0 2 2 2 1 DALR anticodon binding domain Arg_tRNA_synt_N PF03485.16 EMD66757.1 - 2.4e-05 24.8 2.3 3e-05 24.5 0.0 2.3 2 0 0 2 2 2 1 Arginyl tRNA synthetase N terminal domain DivIC PF04977.15 EMD66757.1 - 0.0022 17.7 5.6 0.0058 16.4 3.8 2.3 2 0 0 2 2 2 1 Septum formation initiator APC_N_CC PF16689.5 EMD66757.1 - 0.37 10.9 3.5 0.21 11.7 0.8 2.0 2 0 0 2 2 2 0 Coiled-coil N-terminus of APC, dimerisation domain Prothymosin PF03247.14 EMD66759.1 - 4.2 7.9 8.3 1 9.9 3.2 2.3 2 0 0 2 2 2 0 Prothymosin/parathymosin family RTA1 PF04479.13 EMD66760.1 - 1.8e-75 253.1 3.1 1.8e-75 253.1 3.1 2.0 1 1 1 2 2 2 2 RTA1 like protein COX7B PF05392.11 EMD66760.1 - 0.046 13.4 0.2 0.12 12.0 0.0 1.8 2 0 0 2 2 2 0 Cytochrome C oxidase chain VIIB PHO4 PF01384.20 EMD66760.1 - 0.6 9.1 3.8 0.68 8.9 0.3 2.1 2 0 0 2 2 2 0 Phosphate transporter family Saf_2TM PF18303.1 EMD66760.1 - 2.8 7.5 4.6 1.1 8.8 1.0 2.2 2 1 0 2 2 2 0 SAVED-fused 2TM effector domain DDOST_48kD PF03345.14 EMD66762.1 - 8.6e-155 515.6 0.0 1e-154 515.4 0.0 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase 48 kDa subunit beta GST_N_2 PF13409.6 EMD66763.1 - 5.3e-15 55.5 0.0 1.2e-14 54.4 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EMD66763.1 - 2e-12 46.9 0.0 7.6e-12 45.1 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EMD66763.1 - 0.0095 16.3 0.0 0.26 11.7 0.0 2.5 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EMD66763.1 - 0.014 15.6 0.0 0.027 14.7 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Cation_efflux PF01545.21 EMD66764.1 - 3.9e-51 173.6 10.3 5e-51 173.3 10.3 1.1 1 0 0 1 1 1 1 Cation efflux family BPD_transp_2 PF02653.16 EMD66764.1 - 6.9e-05 22.1 1.3 6.9e-05 22.1 1.3 2.2 2 1 1 3 3 3 1 Branched-chain amino acid transport system / permease component zf-met2 PF12907.7 EMD66765.1 - 1.8e-12 47.2 4.2 2.8e-12 46.6 4.2 1.3 1 0 0 1 1 1 1 Zinc-binding 4F5 PF04419.14 EMD66765.1 - 0.016 16.1 11.2 0.093 13.6 11.2 2.1 1 1 0 1 1 1 0 4F5 protein family DUF3721 PF12518.8 EMD66765.1 - 0.029 14.2 0.7 0.079 12.8 0.5 1.8 2 0 0 2 2 2 0 Protein of unknown function zf-RING_2 PF13639.6 EMD66766.1 - 0.01 16.2 3.5 0.01 16.2 3.5 2.3 2 0 0 2 2 2 0 Ring finger domain Sgf11 PF08209.11 EMD66766.1 - 0.073 12.6 0.2 0.15 11.6 0.2 1.5 1 0 0 1 1 1 0 Sgf11 (transcriptional regulation protein) IBV_3A PF03617.13 EMD66769.1 - 6.2 6.9 6.6 1.3 9.0 0.1 2.9 3 0 0 3 3 3 0 IBV 3A protein PC4 PF02229.16 EMD66771.1 - 1.5e-21 75.8 0.0 2.5e-21 75.0 0.0 1.4 1 0 0 1 1 1 1 Transcriptional Coactivator p15 (PC4) RRM_1 PF00076.22 EMD66772.1 - 1.4e-16 60.1 0.1 9.3e-16 57.4 0.0 2.3 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EMD66772.1 - 0.00091 19.3 0.0 0.0019 18.2 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif DLIC PF05783.11 EMD66773.1 - 1.5e-32 113.1 0.6 6.5e-30 104.4 0.0 3.7 2 2 0 2 2 2 2 Dynein light intermediate chain (DLIC) MSA-2c PF12238.8 EMD66773.1 - 0.19 11.7 2.6 0.44 10.5 0.1 2.5 3 0 0 3 3 3 0 Merozoite surface antigen 2c Preseq_ALAS PF09029.10 EMD66774.1 - 0.0092 16.5 3.3 0.26 11.8 0.6 2.2 1 1 1 2 2 2 2 5-aminolevulinate synthase presequence zf-ANAPC11 PF12861.7 EMD66774.1 - 0.33 11.0 2.3 5.2 7.2 0.4 2.4 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger 4HBT PF03061.22 EMD66776.1 - 8e-13 48.6 0.1 1.1e-12 48.1 0.1 1.2 1 0 0 1 1 1 1 Thioesterase superfamily PXA PF02194.15 EMD66777.1 - 5.3e-30 104.7 0.3 5.3e-30 104.7 0.3 2.2 2 0 0 2 2 2 1 PXA domain Nexin_C PF08628.12 EMD66777.1 - 3.5e-24 85.5 0.0 1.3e-23 83.7 0.0 2.1 1 0 0 1 1 1 1 Sorting nexin C terminal PX PF00787.24 EMD66777.1 - 7.9e-08 32.3 0.0 2.8e-07 30.5 0.0 2.0 1 0 0 1 1 1 1 PX domain Spt5_N PF11942.8 EMD66777.1 - 0.34 11.9 4.3 1.5 9.8 4.3 2.1 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal G0-G1_switch_2 PF15103.6 EMD66777.1 - 0.78 10.2 4.1 1.8 9.0 0.0 3.1 3 0 0 3 3 3 0 G0/G1 switch protein 2 DUF2694 PF10904.8 EMD66778.1 - 0.0085 16.1 2.0 1.6 8.8 0.4 3.5 2 0 0 2 2 2 2 Protein of unknown function (DUF2694) RPN6_N PF18055.1 EMD66779.1 - 6.6e-48 161.9 2.2 1.3e-47 160.9 0.7 2.3 2 0 0 2 2 2 1 26S proteasome regulatory subunit RPN6 N-terminal domain PCI PF01399.27 EMD66779.1 - 1.9e-21 76.5 1.0 4.1e-21 75.5 0.2 2.0 2 1 0 2 2 2 1 PCI domain RPN6_C_helix PF18503.1 EMD66779.1 - 2.5e-10 39.9 0.6 8.1e-10 38.3 0.6 2.0 1 0 0 1 1 1 1 26S proteasome subunit RPN6 C-terminal helix domain TPR_MalT PF17874.1 EMD66779.1 - 4.2e-08 32.9 3.5 0.0004 19.9 0.9 3.2 1 1 1 3 3 3 2 MalT-like TPR region TPR_7 PF13176.6 EMD66779.1 - 8.2e-05 22.4 4.0 0.6 10.3 0.2 4.9 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 EMD66779.1 - 0.00011 22.4 13.5 0.9 9.9 0.7 5.8 6 0 0 6 6 6 2 Tetratricopeptide repeat DDRGK PF09756.9 EMD66779.1 - 0.0038 16.8 0.2 0.009 15.6 0.2 1.6 1 0 0 1 1 1 1 DDRGK domain TPR_19 PF14559.6 EMD66779.1 - 0.022 15.2 8.2 1 9.9 0.2 5.0 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_6 PF13174.6 EMD66779.1 - 0.027 15.1 6.4 4.3 8.2 0.0 5.5 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_14 PF13428.6 EMD66779.1 - 0.046 14.5 8.4 0.74 10.8 0.0 5.4 6 1 1 7 7 5 0 Tetratricopeptide repeat TPR_1 PF00515.28 EMD66779.1 - 0.048 13.5 6.3 9.7 6.2 0.0 5.3 5 1 1 6 6 6 0 Tetratricopeptide repeat NepR PF18557.1 EMD66779.1 - 0.061 13.0 0.0 0.25 11.0 0.0 2.2 1 0 0 1 1 1 0 Anti-sigma factor NepR TPR_11 PF13414.6 EMD66779.1 - 0.08 12.6 4.7 2.3 8.0 0.0 3.5 5 0 0 5 5 5 0 TPR repeat TPR_10 PF13374.6 EMD66779.1 - 0.083 12.8 0.4 86 3.2 0.0 4.5 5 0 0 5 5 4 0 Tetratricopeptide repeat DUF3496 PF12001.8 EMD66779.1 - 0.093 13.1 1.2 1.1 9.6 0.2 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3496) SbsC_C PF18058.1 EMD66779.1 - 0.13 12.5 3.5 0.48 10.7 0.0 3.0 2 1 1 3 3 3 0 SbsC C-terminal domain TPR_8 PF13181.6 EMD66779.1 - 0.42 11.0 9.8 43 4.7 0.0 6.1 6 1 2 8 8 6 0 Tetratricopeptide repeat Prefoldin PF02996.17 EMD66779.1 - 0.6 10.0 4.9 0.62 10.0 0.1 3.0 4 0 0 4 4 3 0 Prefoldin subunit Prefoldin_2 PF01920.20 EMD66779.1 - 0.83 9.6 6.3 0.21 11.6 1.1 2.6 3 0 0 3 3 3 0 Prefoldin subunit zf-LITAF-like PF10601.9 EMD66780.1 - 0.0033 17.6 0.7 0.006 16.8 0.7 1.4 1 0 0 1 1 1 1 LITAF-like zinc ribbon domain zf-C4H2 PF10146.9 EMD66780.1 - 0.021 15.1 6.1 0.025 14.9 6.1 1.1 1 0 0 1 1 1 0 Zinc finger-containing protein DUF737 PF05300.11 EMD66780.1 - 0.035 14.5 2.0 0.039 14.3 2.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF737) CbtA PF09490.10 EMD66780.1 - 0.11 12.2 0.0 0.15 11.8 0.0 1.1 1 0 0 1 1 1 0 Probable cobalt transporter subunit (CbtA) TMEM247 PF15444.6 EMD66780.1 - 0.12 12.4 3.2 0.19 11.8 3.2 1.4 1 0 0 1 1 1 0 Transmembrane protein 247 CrgA PF06781.12 EMD66780.1 - 0.15 12.1 0.8 3.1 7.9 0.0 2.2 1 1 1 2 2 2 0 Cell division protein CrgA DUF3675 PF12428.8 EMD66780.1 - 0.23 12.1 2.2 0.46 11.0 2.2 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3675) TMEM154 PF15102.6 EMD66780.1 - 0.4 10.6 2.2 1.3 9.0 2.2 1.8 1 1 0 1 1 1 0 TMEM154 protein family DUF3328 PF11807.8 EMD66783.1 - 2.4e-12 47.1 5.4 3.1e-12 46.7 5.4 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) Mito_carr PF00153.27 EMD66784.1 - 4.8e-48 161.0 0.2 2e-16 59.7 0.0 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein RRF PF01765.19 EMD66784.1 - 0.087 12.8 1.6 0.16 11.9 1.6 1.4 1 0 0 1 1 1 0 Ribosome recycling factor RXLR_WY PF18634.1 EMD66784.1 - 0.13 12.2 0.0 0.42 10.6 0.0 1.8 1 0 0 1 1 1 0 RXLR phytopathogen effector protein WY-domain DUF883 PF05957.13 EMD66784.1 - 0.22 12.1 3.9 0.89 10.2 2.7 2.4 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) FAM25 PF15825.5 EMD66784.1 - 0.25 11.7 9.3 3.9 7.9 3.0 2.6 1 1 1 2 2 2 0 FAM25 family YtxH PF12732.7 EMD66784.1 - 0.31 11.6 10.3 1.9 9.1 1.6 3.0 2 1 1 3 3 3 0 YtxH-like protein Chlorosome_CsmC PF11098.8 EMD66784.1 - 8.8 6.3 9.4 8.4 6.4 6.3 2.4 2 1 1 3 3 3 0 Chlorosome envelope protein C NUDE_C PF04880.13 EMD66785.1 - 5e-41 141.1 11.2 5e-41 141.1 11.2 4.1 2 1 2 4 4 1 1 NUDE protein, C-terminal conserved region PSII_Pbs27 PF13326.6 EMD66785.1 - 0.035 14.4 6.1 0.076 13.3 6.1 1.5 1 0 0 1 1 1 0 Photosystem II Pbs27 Tropomyosin_1 PF12718.7 EMD66785.1 - 0.27 11.4 37.8 5.4 7.2 5.5 3.6 2 1 1 3 3 3 0 Tropomyosin like TPR_MLP1_2 PF07926.12 EMD66785.1 - 0.41 10.7 39.0 1.5 8.9 9.3 3.6 2 1 2 4 4 4 0 TPR/MLP1/MLP2-like protein Fez1 PF06818.15 EMD66785.1 - 1 9.7 33.2 0.84 10.1 14.9 2.5 2 1 1 3 3 2 0 Fez1 ZapB PF06005.12 EMD66785.1 - 1.1 9.8 40.6 0.1 13.0 7.1 4.0 3 1 1 4 4 4 0 Cell division protein ZapB ERM PF00769.19 EMD66785.1 - 5.7 6.7 40.1 1.7 8.4 11.3 2.3 1 1 1 2 2 2 0 Ezrin/radixin/moesin family Chibby PF14645.6 EMD66785.1 - 5.7 7.4 16.0 6.4 7.2 7.1 3.2 1 1 2 3 3 3 0 Chibby family CENP-F_leu_zip PF10473.9 EMD66785.1 - 6.3 6.8 39.3 6.1 6.9 25.2 3.2 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 PRKG1_interact PF15898.5 EMD66785.1 - 7 7.6 29.5 0.85 10.6 12.4 3.0 2 1 2 4 4 3 0 cGMP-dependent protein kinase interacting domain GrpE PF01025.19 EMD66785.1 - 7.3 6.2 33.2 0.018 14.7 13.4 3.1 1 1 2 3 3 3 0 GrpE Seryl_tRNA_N PF02403.22 EMD66785.1 - 8.9 6.6 23.4 0.56 10.5 12.8 2.7 1 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain APG6_N PF17675.1 EMD66785.1 - 9.6 6.7 46.7 24 5.4 15.3 3.2 1 1 2 3 3 3 0 Apg6 coiled-coil region ACC_central PF08326.12 EMD66788.1 - 2.1e-279 928.9 0.0 2.6e-279 928.5 0.0 1.1 1 0 0 1 1 1 1 Acetyl-CoA carboxylase, central region Carboxyl_trans PF01039.22 EMD66788.1 - 4.8e-186 619.2 0.0 8.1e-186 618.5 0.0 1.4 1 0 0 1 1 1 1 Carboxyl transferase domain CPSase_L_D2 PF02786.17 EMD66788.1 - 5.7e-53 179.6 0.0 1.1e-52 178.6 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 EMD66788.1 - 2.4e-28 98.9 0.1 4.5e-28 98.0 0.1 1.5 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 EMD66788.1 - 1e-21 77.0 0.0 1.6e-20 73.2 0.0 3.0 4 0 0 4 4 4 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 EMD66788.1 - 4.6e-17 61.6 0.0 1.3e-16 60.1 0.0 1.9 1 0 0 1 1 1 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.13 EMD66788.1 - 0.00035 20.2 0.0 0.001 18.6 0.0 1.8 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp_3 PF02655.14 EMD66788.1 - 0.00058 19.9 0.0 0.0029 17.7 0.0 2.3 3 0 0 3 3 3 1 ATP-grasp domain GxGYxYP_N PF16216.5 EMD66788.1 - 0.041 14.1 0.1 0.087 13.0 0.1 1.4 1 0 0 1 1 1 0 GxGYxY sequence motif in domain of unknown function N-terminal ABM PF03992.16 EMD66789.1 - 1.8e-05 24.8 0.0 3e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase FemAB_like PF04339.12 EMD66789.1 - 0.0078 15.4 0.1 0.0078 15.4 0.1 1.1 1 0 0 1 1 1 1 Peptidogalycan biosysnthesis/recognition DDE_Tnp_1_7 PF13843.6 EMD66789.1 - 0.04 13.2 0.0 0.061 12.6 0.0 1.2 1 1 0 1 1 1 0 Transposase IS4 COX7a PF02238.15 EMD66791.1 - 9.6e-17 61.1 0.4 1.1e-16 60.9 0.4 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VII DUF1682 PF07946.14 EMD66792.1 - 1e-111 373.3 1.6 1.2e-111 373.1 1.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1682) eIF-5a PF01287.20 EMD66794.1 - 5.5e-05 23.2 0.1 0.0001 22.3 0.1 1.5 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold CH PF00307.31 EMD66795.1 - 1.8e-75 250.1 0.2 7.3e-21 74.4 0.1 4.2 4 0 0 4 4 4 4 Calponin homology (CH) domain EF-hand_7 PF13499.6 EMD66795.1 - 3.5e-07 30.6 1.4 1.5e-06 28.6 0.4 2.4 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 EMD66795.1 - 5.3e-05 22.8 0.4 0.0024 17.7 0.0 3.0 3 0 0 3 3 3 1 EF-hand domain EF-hand_1 PF00036.32 EMD66795.1 - 0.00011 21.4 0.9 0.079 12.5 0.1 3.5 3 0 0 3 3 3 1 EF hand CAMSAP_CH PF11971.8 EMD66795.1 - 0.0037 17.1 0.0 0.54 10.1 0.0 3.4 3 0 0 3 3 3 1 CAMSAP CH domain EF-hand_5 PF13202.6 EMD66795.1 - 0.2 11.2 2.4 0.79 9.3 0.3 2.7 2 0 0 2 2 2 0 EF hand KilA-N PF04383.13 EMD66796.1 - 4.3e-05 23.3 0.0 0.00073 19.4 0.0 2.2 1 1 0 1 1 1 1 KilA-N domain CbbQ_C PF08406.10 EMD66799.1 - 0.085 13.1 0.1 0.15 12.4 0.1 1.3 1 0 0 1 1 1 0 CbbQ/NirQ/NorQ C-terminal FAD_binding_4 PF01565.23 EMD66802.1 - 2e-22 79.5 1.4 4.9e-22 78.2 1.4 1.7 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EMD66802.1 - 1.4e-06 28.3 0.3 2.8e-06 27.3 0.3 1.6 1 0 0 1 1 1 1 Berberine and berberine like HAD_2 PF13419.6 EMD66803.1 - 2.6e-19 70.0 0.1 1.5e-18 67.6 0.1 1.9 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EMD66803.1 - 1e-13 52.1 0.1 1.4e-13 51.6 0.1 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EMD66803.1 - 5.7e-07 29.5 0.0 1.2e-06 28.5 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like HAD PF12710.7 EMD66803.1 - 1.1e-06 29.2 0.1 2.4e-06 28.1 0.1 1.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 EMD66803.1 - 0.014 15.5 0.0 0.16 12.1 0.0 2.4 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Acid_phosphat_B PF03767.14 EMD66803.1 - 0.12 11.9 0.0 17 4.9 0.0 2.5 2 0 0 2 2 2 0 HAD superfamily, subfamily IIIB (Acid phosphatase) WD40 PF00400.32 EMD66804.1 - 8.4e-30 102.4 4.6 1.1e-07 32.4 0.1 6.6 7 0 0 7 7 7 4 WD domain, G-beta repeat Sof1 PF04158.14 EMD66804.1 - 1.6e-29 102.0 17.0 3.2e-29 101.0 17.0 1.5 1 0 0 1 1 1 1 Sof1-like domain ANAPC4_WD40 PF12894.7 EMD66804.1 - 2.1e-10 40.7 0.1 0.015 15.6 0.0 4.4 3 1 1 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Frtz PF11768.8 EMD66804.1 - 6.5e-05 21.4 0.0 0.18 10.1 0.0 2.8 1 1 2 3 3 3 2 WD repeat-containing and planar cell polarity effector protein Fritz eIF2A PF08662.11 EMD66804.1 - 0.0026 17.7 0.5 0.19 11.6 0.0 2.5 2 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 EMD66804.1 - 0.0037 16.3 0.0 0.4 9.6 0.0 3.0 1 1 2 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Ribosomal_L27e PF01777.18 EMD66805.1 - 1.9e-36 124.3 8.2 2.6e-36 123.8 8.2 1.2 1 0 0 1 1 1 1 Ribosomal L27e protein family KOW PF00467.29 EMD66805.1 - 0.00015 21.6 0.2 0.00043 20.1 0.2 1.8 1 0 0 1 1 1 1 KOW motif Perilipin PF03036.16 EMD66806.1 - 0.017 14.2 0.0 0.02 14.0 0.0 1.2 1 0 0 1 1 1 0 Perilipin family RNA_pol_Rpb1_5 PF04998.17 EMD66807.1 - 1.5e-87 293.4 0.3 4.4e-87 291.9 0.2 1.9 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 EMD66807.1 - 2.8e-67 226.1 1.3 3.6e-67 225.8 0.2 1.8 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 EMD66807.1 - 2.3e-32 112.1 0.0 2.3e-31 108.9 0.0 2.7 3 1 1 4 4 4 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_1 PF04997.12 EMD66807.1 - 5.6e-26 91.6 5.2 7e-24 84.7 2.9 3.5 2 1 0 2 2 2 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_4 PF05000.17 EMD66807.1 - 7.3e-19 67.7 0.8 2.9e-18 65.8 0.0 2.5 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 4 Thioredoxin PF00085.20 EMD66807.1 - 0.11 12.5 0.0 0.35 10.9 0.0 1.9 1 0 0 1 1 1 0 Thioredoxin PRP3 PF08572.10 EMD66808.1 - 1.2e-66 224.7 1.4 2.4e-66 223.7 1.4 1.5 1 0 0 1 1 1 1 pre-mRNA processing factor 3 (PRP3) DUF1115 PF06544.12 EMD66808.1 - 2e-43 148.0 0.0 2e-43 148.0 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF1115) BLUF PF04940.12 EMD66808.1 - 0.017 15.2 0.1 6.4 7.0 0.0 2.6 2 0 0 2 2 2 0 Sensors of blue-light using FAD muHD PF10291.9 EMD66809.1 - 5.3e-74 249.0 0.0 7.7e-74 248.4 0.0 1.2 1 0 0 1 1 1 1 Muniscin C-terminal mu homology domain FCH PF00611.23 EMD66809.1 - 4.8e-09 36.4 0.0 1.3e-08 35.0 0.0 1.8 1 0 0 1 1 1 1 Fes/CIP4, and EFC/F-BAR homology domain DUF885 PF05960.11 EMD66809.1 - 0.0097 15.6 4.2 0.021 14.5 4.2 1.6 1 1 0 1 1 1 1 Bacterial protein of unknown function (DUF885) RE_AlwI PF09491.10 EMD66809.1 - 0.032 13.0 1.0 0.045 12.5 1.0 1.1 1 0 0 1 1 1 0 AlwI restriction endonuclease Mo25 PF08569.11 EMD66810.1 - 2.6e-113 378.7 0.2 6.8e-112 374.1 0.2 2.0 1 1 0 1 1 1 1 Mo25-like Pkinase PF00069.25 EMD66810.1 - 1.9e-32 112.7 0.0 4.1e-32 111.6 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD66810.1 - 1.9e-14 53.6 0.0 4.6e-14 52.3 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 EMD66810.1 - 0.051 12.9 0.0 0.087 12.1 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Pkinase_fungal PF17667.1 EMD66810.1 - 0.063 12.1 0.0 0.097 11.4 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase TPT PF03151.16 EMD66811.1 - 4.7e-22 78.7 9.3 9.5e-22 77.7 9.3 1.5 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 EMD66811.1 - 1.3e-05 25.4 31.2 0.011 15.9 8.0 2.6 2 1 0 2 2 2 2 EamA-like transporter family YL1 PF05764.13 EMD66811.1 - 0.0021 18.2 3.5 0.0033 17.6 3.5 1.3 1 0 0 1 1 1 1 YL1 nuclear protein UAA PF08449.11 EMD66811.1 - 0.0046 16.2 18.6 0.008 15.4 14.8 2.1 2 0 0 2 2 2 1 UAA transporter family CDC45 PF02724.14 EMD66811.1 - 0.082 11.2 3.7 0.12 10.7 3.7 1.1 1 0 0 1 1 1 0 CDC45-like protein PUNUT PF16913.5 EMD66811.1 - 0.14 11.4 14.3 0.073 12.3 11.3 1.8 2 0 0 2 2 2 0 Purine nucleobase transmembrane transport STIMATE PF12400.8 EMD66812.1 - 5.2e-43 146.6 2.4 9.3e-43 145.7 2.4 1.4 1 0 0 1 1 1 1 STIMATE family FKBP_C PF00254.28 EMD66812.1 - 1.3e-29 102.4 0.0 2e-29 101.8 0.0 1.3 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase CD52 PF15116.6 EMD66812.1 - 3.8 7.6 5.0 4.1 7.5 0.4 2.8 3 0 0 3 3 3 0 CAMPATH-1 antigen CoA_trans PF01144.23 EMD66813.1 - 1.2e-101 338.6 0.8 4e-61 206.2 0.2 2.0 2 0 0 2 2 2 2 Coenzyme A transferase Mal_decarbox_Al PF16957.5 EMD66813.1 - 0.0016 16.9 0.1 0.059 11.7 0.1 2.1 2 0 0 2 2 2 2 Malonate decarboxylase, alpha subunit, transporter HATPase_c PF02518.26 EMD66814.1 - 7.8e-27 94.0 0.1 1.7e-26 92.9 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS_3 PF08447.12 EMD66814.1 - 1.4e-17 63.7 2.3 2.2e-09 37.5 0.6 3.5 3 0 0 3 3 3 3 PAS fold HisKA PF00512.25 EMD66814.1 - 2.7e-17 62.5 0.1 6.4e-17 61.3 0.1 1.7 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain Response_reg PF00072.24 EMD66814.1 - 7.2e-16 58.3 0.0 2.1e-15 56.9 0.0 1.8 2 0 0 2 2 2 1 Response regulator receiver domain PAS PF00989.25 EMD66814.1 - 3.2e-13 49.7 0.0 2.7e-06 27.4 0.0 2.6 2 0 0 2 2 2 2 PAS fold PAS_4 PF08448.10 EMD66814.1 - 2.6e-06 27.6 0.0 0.00012 22.3 0.0 2.8 2 0 0 2 2 2 1 PAS fold PAS_9 PF13426.7 EMD66814.1 - 5.5e-06 26.6 0.0 0.0079 16.4 0.0 3.3 2 1 0 2 2 2 1 PAS domain PAS_8 PF13188.7 EMD66814.1 - 1.5e-05 24.9 0.0 0.0033 17.4 0.0 2.6 2 0 0 2 2 2 1 PAS domain Cytochrom_B561 PF03188.16 EMD66815.1 - 6.4e-18 65.2 5.1 6.4e-18 65.2 5.1 1.4 2 0 0 2 2 2 1 Eukaryotic cytochrome b561 BTB PF00651.31 EMD66816.1 - 4.7e-20 71.9 0.1 5.3e-09 36.3 0.0 3.4 4 0 0 4 4 4 2 BTB/POZ domain Ufm1 PF03671.14 EMD66816.1 - 0.1 12.7 0.0 11 6.2 0.0 2.7 2 0 0 2 2 2 0 Ubiquitin fold modifier 1 protein Glyco_hydro_16 PF00722.21 EMD66817.1 - 2.1e-06 27.3 2.2 3.6e-06 26.6 2.2 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 GDP_Man_Dehyd PF16363.5 EMD66818.1 - 3.6e-35 121.9 0.0 2.2e-34 119.4 0.0 1.9 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 EMD66818.1 - 1.1e-33 116.7 0.0 1.9e-33 115.9 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EMD66818.1 - 3e-09 36.4 0.0 8.4e-08 31.7 0.0 2.5 2 2 1 4 4 4 1 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.19 EMD66818.1 - 7.7e-07 28.4 0.0 5.3e-06 25.6 0.0 2.0 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 EMD66818.1 - 1e-06 28.1 0.0 1.4e-06 27.7 0.0 1.3 1 1 0 1 1 1 1 Male sterility protein KR PF08659.10 EMD66818.1 - 0.00032 20.6 0.0 0.00064 19.7 0.0 1.4 1 0 0 1 1 1 1 KR domain adh_short PF00106.25 EMD66818.1 - 0.0033 16.9 0.0 0.0052 16.3 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase UDPG_MGDP_dh_N PF03721.14 EMD66818.1 - 0.029 13.9 0.1 0.066 12.8 0.1 1.5 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain RmlD_sub_bind PF04321.17 EMD66818.1 - 0.079 12.0 0.0 0.37 9.8 0.0 2.2 1 1 0 1 1 1 0 RmlD substrate binding domain 3HCDH_N PF02737.18 EMD66818.1 - 0.15 12.0 0.0 0.42 10.5 0.0 1.8 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Glyco_tranf_2_3 PF13641.6 EMD66819.1 - 8e-06 25.9 0.0 2.5e-05 24.3 0.0 1.7 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 EMD66819.1 - 2.4e-05 24.2 0.0 4.6e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_trans_2_3 PF13632.6 EMD66819.1 - 3.7e-05 23.7 1.5 5.3e-05 23.2 1.5 1.3 1 0 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_transf_21 PF13506.6 EMD66819.1 - 0.00089 18.8 0.1 0.0031 17.0 0.1 1.8 1 1 0 1 1 1 1 Glycosyl transferase family 21 Acetyltransf_3 PF13302.7 EMD66820.1 - 5.5e-18 66.0 0.8 1.7e-17 64.4 0.8 1.8 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EMD66820.1 - 2.9e-10 40.4 0.0 4.3e-10 39.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_8 PF13523.6 EMD66820.1 - 4.9e-06 26.3 0.0 9.2e-06 25.4 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 EMD66820.1 - 6.2e-05 23.2 0.0 0.00016 21.9 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EMD66820.1 - 0.00096 19.1 0.1 0.002 18.1 0.1 1.5 1 0 0 1 1 1 1 FR47-like protein MFS_1 PF07690.16 EMD66822.1 - 1.5e-26 93.1 27.5 1.5e-26 93.1 27.5 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily PQ-loop PF04193.14 EMD66823.1 - 1.2e-20 73.0 6.6 9.7e-20 70.1 0.9 2.8 2 1 0 2 2 2 2 PQ loop repeat ABC2_membrane_5 PF13346.6 EMD66823.1 - 0.95 9.0 10.2 0.13 11.8 5.6 1.7 2 0 0 2 2 2 0 ABC-2 family transporter protein MtN3_slv PF03083.16 EMD66823.1 - 1.2 9.2 6.1 0.18 11.9 0.9 2.3 2 2 1 3 3 3 0 Sugar efflux transporter for intercellular exchange DUF3302 PF11742.8 EMD66825.1 - 0.01 15.9 0.1 0.024 14.8 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3302) DHHC PF01529.20 EMD66825.1 - 2.1 8.4 7.5 19 5.3 7.1 2.3 1 1 1 2 2 2 0 DHHC palmitoyltransferase F-box PF00646.33 EMD66828.1 - 0.0061 16.4 0.9 0.016 15.1 0.2 2.1 2 0 0 2 2 2 1 F-box domain Bys1 PF04681.12 EMD66829.1 - 1.3e-10 41.4 0.2 1.7e-10 41.0 0.2 1.1 1 0 0 1 1 1 1 Blastomyces yeast-phase-specific protein AFP PF02420.15 EMD66829.1 - 0.083 13.3 4.4 4.9 7.8 0.1 3.6 3 0 0 3 3 3 0 Insect antifreeze protein repeat SLAC1 PF03595.17 EMD66830.1 - 2.7e-69 233.9 32.7 3e-69 233.8 32.7 1.0 1 0 0 1 1 1 1 Voltage-dependent anion channel Adeno_E3 PF06040.11 EMD66830.1 - 2.5 8.3 8.3 3.5 7.8 0.0 2.8 3 0 0 3 3 3 0 Adenovirus E3 protein DUF3328 PF11807.8 EMD66831.1 - 0.0056 16.5 6.8 0.87 9.3 6.8 2.2 1 1 0 1 1 1 1 Domain of unknown function (DUF3328) Acetyltransf_10 PF13673.7 EMD66832.1 - 3.6e-08 33.4 0.0 1.3e-07 31.6 0.0 1.8 1 1 1 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EMD66832.1 - 8.8e-08 32.4 0.1 2.5e-07 30.9 0.1 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EMD66832.1 - 1.5e-07 31.7 0.0 3.1e-07 30.7 0.0 1.8 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EMD66832.1 - 4.5e-05 23.3 0.0 0.0012 18.7 0.0 2.1 1 1 1 2 2 2 1 FR47-like protein Acetyltransf_CG PF14542.6 EMD66832.1 - 0.0028 17.8 0.0 0.0073 16.4 0.0 1.7 1 1 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_9 PF13527.7 EMD66832.1 - 0.0052 16.9 0.0 0.012 15.6 0.0 1.8 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain His_biosynth PF00977.21 EMD66832.1 - 0.07 12.6 0.0 0.094 12.2 0.0 1.2 1 0 0 1 1 1 0 Histidine biosynthesis protein Zn_clus PF00172.18 EMD66833.1 - 0.00054 20.0 8.4 0.00054 20.0 8.4 2.1 3 0 0 3 3 3 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ADH_zinc_N PF00107.26 EMD66834.1 - 2.1e-07 31.0 0.0 3.1e-07 30.4 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase zf-UBP PF02148.19 EMD66834.1 - 0.2 12.0 0.1 1.6 9.1 0.0 2.0 2 0 0 2 2 2 0 Zn-finger in ubiquitin-hydrolases and other protein DLH PF01738.18 EMD66835.1 - 0.00019 21.0 0.0 0.00026 20.6 0.0 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family DUF3328 PF11807.8 EMD66836.1 - 0.00071 19.4 1.9 0.018 14.8 0.4 2.1 2 0 0 2 2 2 2 Domain of unknown function (DUF3328) MFS_2 PF13347.6 EMD66837.1 - 9.2e-10 37.6 7.1 9.2e-10 37.6 7.1 2.6 2 0 0 2 2 2 1 MFS/sugar transport protein Cupredoxin_1 PF13473.6 EMD66838.1 - 1.7e-05 24.9 25.5 0.076 13.1 3.0 5.0 1 1 4 5 5 5 5 Cupredoxin-like domain Condensation PF00668.20 EMD66839.1 - 0 1260.7 0.0 2.7e-53 181.3 0.0 9.4 9 0 0 9 9 9 9 Condensation domain AMP-binding PF00501.28 EMD66839.1 - 0 1011.0 2.6 5.8e-79 265.6 0.5 4.7 4 0 0 4 4 4 4 AMP-binding enzyme PP-binding PF00550.25 EMD66839.1 - 3.5e-71 235.5 12.5 1.3e-12 47.9 0.1 7.9 7 0 0 7 7 7 7 Phosphopantetheine attachment site Transferase PF02458.15 EMD66839.1 - 3e-11 42.6 0.2 0.00038 19.2 0.0 5.6 6 1 0 6 6 6 3 Transferase family AMP-binding_C PF13193.6 EMD66839.1 - 8.5e-05 23.5 0.0 0.71 10.9 0.0 4.3 4 0 0 4 4 4 1 AMP-binding enzyme C-terminal domain ABC_tran PF00005.27 EMD66840.1 - 2e-43 148.2 0.0 2.4e-23 83.2 0.0 2.5 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EMD66840.1 - 4.6e-35 121.6 29.3 1.5e-27 96.9 13.1 2.4 2 0 0 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.19 EMD66840.1 - 5.1e-11 42.4 2.0 0.0015 18.0 0.1 4.3 4 0 0 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EMD66840.1 - 5.7e-08 32.9 0.1 0.036 13.9 0.0 3.5 2 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EMD66840.1 - 3.9e-07 29.7 2.1 0.02 14.6 0.0 3.2 3 0 0 3 3 3 2 P-loop containing region of AAA domain AAA_16 PF13191.6 EMD66840.1 - 5.9e-06 26.8 0.1 0.15 12.4 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain MMR_HSR1 PF01926.23 EMD66840.1 - 8.9e-06 25.8 0.0 0.022 14.8 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EMD66840.1 - 1e-05 25.5 0.3 0.045 13.7 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_7 PF12775.7 EMD66840.1 - 2.3e-05 24.0 0.1 0.079 12.5 0.0 2.4 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_22 PF13401.6 EMD66840.1 - 2.5e-05 24.5 3.3 0.031 14.6 0.2 3.4 3 0 0 3 3 3 1 AAA domain AAA_23 PF13476.6 EMD66840.1 - 8.4e-05 23.2 0.1 0.23 11.9 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.6 EMD66840.1 - 9.7e-05 22.0 0.0 0.33 10.5 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA PF00004.29 EMD66840.1 - 0.0012 19.2 0.3 0.069 13.6 0.0 3.0 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) ATPase_2 PF01637.18 EMD66840.1 - 0.0052 16.7 0.1 0.24 11.3 0.0 2.8 3 0 0 3 3 2 1 ATPase domain predominantly from Archaea Viral_helicase1 PF01443.18 EMD66840.1 - 0.0064 16.3 0.5 2.2 7.9 0.0 3.0 4 0 0 4 4 2 1 Viral (Superfamily 1) RNA helicase AAA_PrkA PF08298.11 EMD66840.1 - 0.008 15.1 0.2 2.1 7.2 0.0 2.2 2 0 0 2 2 2 1 PrkA AAA domain AAA_33 PF13671.6 EMD66840.1 - 0.0089 16.2 0.4 0.16 12.2 0.1 2.5 2 0 0 2 2 2 1 AAA domain NB-ARC PF00931.22 EMD66840.1 - 0.01 15.1 0.3 3.2 6.9 0.1 2.4 2 0 0 2 2 2 0 NB-ARC domain Dynamin_N PF00350.23 EMD66840.1 - 0.01 15.9 2.8 1.3 9.0 0.3 2.4 2 0 0 2 2 2 0 Dynamin family RNA_helicase PF00910.22 EMD66840.1 - 0.011 16.1 0.1 5.4 7.5 0.0 3.2 2 1 0 2 2 2 0 RNA helicase DUF815 PF05673.13 EMD66840.1 - 0.017 14.3 0.2 5.7 6.0 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF815) T2SSE PF00437.20 EMD66840.1 - 0.019 14.1 0.0 0.6 9.1 0.0 2.4 2 0 0 2 2 2 0 Type II/IV secretion system protein cobW PF02492.19 EMD66840.1 - 0.02 14.5 1.4 0.92 9.1 0.5 2.7 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Sigma54_activat PF00158.26 EMD66840.1 - 0.027 14.2 0.0 0.9 9.2 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain NACHT PF05729.12 EMD66840.1 - 0.029 14.3 0.7 5.6 6.8 0.1 2.9 3 0 0 3 3 2 0 NACHT domain AAA_30 PF13604.6 EMD66840.1 - 0.041 13.6 0.3 4 7.1 0.0 2.8 3 0 0 3 3 3 0 AAA domain FtsK_SpoIIIE PF01580.18 EMD66840.1 - 0.06 12.7 0.1 0.89 8.8 0.0 2.2 2 0 0 2 2 2 0 FtsK/SpoIIIE family Adeno_IVa2 PF02456.15 EMD66840.1 - 0.068 12.0 0.3 1.3 7.8 0.0 2.2 2 0 0 2 2 2 0 Adenovirus IVa2 protein AAA_15 PF13175.6 EMD66840.1 - 0.069 12.8 0.1 12 5.5 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain PduV-EutP PF10662.9 EMD66840.1 - 0.081 12.7 0.8 1.9 8.3 0.1 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation IstB_IS21 PF01695.17 EMD66840.1 - 0.088 12.5 0.2 45 3.7 0.0 3.6 4 0 0 4 4 4 0 IstB-like ATP binding protein AAA_5 PF07728.14 EMD66840.1 - 0.12 12.4 0.7 24 4.9 0.2 2.8 3 0 0 3 3 2 0 AAA domain (dynein-related subfamily) Roc PF08477.13 EMD66840.1 - 0.14 12.4 2.1 6.6 7.0 0.1 3.4 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase AAA_14 PF13173.6 EMD66840.1 - 0.14 12.2 0.4 1.3 9.1 0.0 2.6 3 0 0 3 3 2 0 AAA domain SbcCD_C PF13558.6 EMD66840.1 - 0.17 12.2 1.0 8.1 6.8 0.0 3.0 3 0 0 3 3 2 0 Putative exonuclease SbcCD, C subunit AAA_24 PF13479.6 EMD66840.1 - 0.18 11.5 0.2 8.6 6.0 0.0 2.4 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 EMD66840.1 - 0.18 11.1 0.4 8.6 5.6 0.1 2.7 2 0 0 2 2 2 0 Zeta toxin ABC_ATPase PF09818.9 EMD66840.1 - 0.2 10.4 4.4 0.14 10.9 0.1 2.7 3 0 0 3 3 3 0 Predicted ATPase of the ABC class Septin PF00735.18 EMD66840.1 - 0.21 10.8 0.3 18 4.5 0.1 2.2 2 0 0 2 2 2 0 Septin NTPase_1 PF03266.15 EMD66840.1 - 0.22 11.4 1.3 11 5.8 0.2 3.0 3 0 0 3 3 3 0 NTPase ATP-synt_ab PF00006.25 EMD66840.1 - 0.25 11.0 0.7 22 4.6 0.0 2.6 3 0 0 3 3 2 0 ATP synthase alpha/beta family, nucleotide-binding domain DUF87 PF01935.17 EMD66840.1 - 0.28 11.3 2.6 0.16 12.0 0.2 1.8 2 0 0 2 2 1 0 Helicase HerA, central domain Pox_A32 PF04665.12 EMD66840.1 - 0.39 10.1 1.1 0.55 9.7 0.1 1.7 2 0 0 2 2 1 0 Poxvirus A32 protein MFS_1 PF07690.16 EMD66842.1 - 1.9e-20 73.1 33.1 1.9e-20 73.1 33.1 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Phage_holin_2_3 PF16080.5 EMD66842.1 - 0.13 12.0 3.0 8.9 6.2 0.3 3.8 3 0 0 3 3 3 0 Bacteriophage holin family HP1 HET PF06985.11 EMD66844.1 - 8.9e-30 104.0 0.1 2.3e-29 102.6 0.1 1.6 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) GSH-S_ATP PF02955.16 EMD66845.1 - 0.0073 15.7 0.0 0.021 14.2 0.0 1.7 1 1 0 1 1 1 1 Prokaryotic glutathione synthetase, ATP-grasp domain SH3_12 PF18129.1 EMD66845.1 - 0.13 12.4 0.0 0.22 11.7 0.0 1.3 1 0 0 1 1 1 0 Xrn1 SH3-like domain WSC PF01822.19 EMD66846.1 - 2.5e-38 130.1 30.2 9.1e-21 73.9 11.6 3.0 3 0 0 3 3 3 2 WSC domain Trypan_PARP PF05887.11 EMD66846.1 - 0.021 14.8 7.1 0.039 13.9 7.1 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Pkinase PF00069.25 EMD66847.1 - 5.3e-16 58.8 0.0 1.5e-10 40.9 0.0 2.4 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EMD66847.1 - 1.4e-07 31.1 0.0 2.4e-07 30.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMD66848.1 - 1.7e-25 89.9 0.0 2.9e-25 89.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain HET PF06985.11 EMD66848.1 - 7.4e-23 81.5 0.0 1.6e-22 80.4 0.0 1.6 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Pkinase_Tyr PF07714.17 EMD66848.1 - 1.4e-16 60.6 0.0 2.4e-16 59.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase HeLo PF14479.6 EMD66849.1 - 3.8e-50 170.6 0.0 7.3e-50 169.7 0.0 1.4 1 0 0 1 1 1 1 Prion-inhibition and propagation zf-RING_10 PF16685.5 EMD66850.1 - 1 9.5 6.1 0.29 11.3 2.0 1.9 1 1 0 2 2 2 0 zinc RING finger of MSL2 Fusion_gly PF00523.18 EMD66850.1 - 1.1 7.4 3.8 1.2 7.3 3.8 1.0 1 0 0 1 1 1 0 Fusion glycoprotein F0 DAO PF01266.24 EMD66851.1 - 7.2e-14 52.1 0.2 8e-14 52.0 0.2 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EMD66851.1 - 0.091 12.0 0.1 0.15 11.3 0.1 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Ldh_1_N PF00056.23 EMD66851.1 - 0.1 12.7 0.1 0.74 9.9 0.1 2.0 1 1 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain Pyr_redox PF00070.27 EMD66851.1 - 0.27 11.8 0.1 0.27 11.8 0.1 1.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Peptidase_S10 PF00450.22 EMD66855.1 - 5.6e-77 259.9 0.0 7.6e-77 259.5 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase dCMP_cyt_deam_1 PF00383.23 EMD66856.1 - 4.9e-26 90.5 2.0 7.1e-26 90.0 2.0 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EMD66856.1 - 5.5e-09 35.9 0.2 8.9e-09 35.2 0.2 1.3 1 0 0 1 1 1 1 MafB19-like deaminase CoaE PF01121.20 EMD66856.1 - 0.12 12.1 0.0 0.22 11.2 0.0 1.5 1 0 0 1 1 1 0 Dephospho-CoA kinase ATG7_N PF16420.5 EMD66857.1 - 1.2e-108 363.4 0.0 1.5e-108 363.0 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-like modifier-activating enzyme ATG7 N-terminus ThiF PF00899.21 EMD66857.1 - 1.2e-42 146.0 0.0 2.3e-42 145.0 0.0 1.4 1 1 0 1 1 1 1 ThiF family Shikimate_DH PF01488.20 EMD66857.1 - 0.024 14.7 0.0 0.58 10.2 0.0 2.2 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Mg_trans_NIPA PF05653.14 EMD66858.1 - 6.2e-89 298.0 24.8 8.2e-89 297.6 24.8 1.1 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 EMD66858.1 - 0.00051 20.2 4.5 0.00051 20.2 4.5 3.3 3 0 0 3 3 3 1 EamA-like transporter family DUF5362 PF17319.2 EMD66858.1 - 0.081 12.8 3.0 0.16 11.8 0.0 2.9 3 0 0 3 3 3 0 Family of unknown function (DUF5362) Glyco_hydro_125 PF06824.11 EMD66859.1 - 8.4e-148 492.7 0.1 9e-146 486.0 0.1 2.2 1 1 0 1 1 1 1 Metal-independent alpha-mannosidase (GH125) COG4 PF08318.12 EMD66859.1 - 4.5e-118 394.2 0.0 6.2e-118 393.7 0.0 1.2 1 0 0 1 1 1 1 COG4 transport protein NMO PF03060.15 EMD66860.1 - 7.5e-28 97.9 10.9 7e-24 84.8 7.0 2.5 2 1 0 2 2 2 2 Nitronate monooxygenase FMN_dh PF01070.18 EMD66860.1 - 6e-08 32.1 2.4 8.1e-08 31.7 2.4 1.4 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Glu_synthase PF01645.17 EMD66860.1 - 6.1e-05 22.3 2.0 9.9e-05 21.6 2.0 1.3 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.25 EMD66860.1 - 0.0037 16.3 5.6 0.069 12.1 5.6 2.2 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain Abhydrolase_1 PF00561.20 EMD66862.1 - 2.5e-22 79.8 0.1 9e-22 77.9 0.1 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydro_lipase PF04083.16 EMD66862.1 - 9.4e-22 76.4 0.1 1.9e-21 75.4 0.1 1.6 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region FSH1 PF03959.13 EMD66862.1 - 9.7e-05 22.1 0.6 0.055 13.1 0.0 2.7 3 0 0 3 3 3 2 Serine hydrolase (FSH1) Hydrolase_4 PF12146.8 EMD66862.1 - 0.00013 21.3 0.0 0.049 12.9 0.0 2.3 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Pet191_N PF10203.9 EMD66863.1 - 2.5e-27 95.0 2.7 3.1e-27 94.7 2.7 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein PET191 Cmc1 PF08583.10 EMD66863.1 - 0.1 12.6 1.5 1.9 8.5 0.0 2.2 2 0 0 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like CX9C PF16860.5 EMD66863.1 - 9.6 6.3 7.5 37 4.4 0.1 2.8 1 1 2 3 3 3 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Fungal_trans_2 PF11951.8 EMD66864.1 - 2.2e-20 72.8 1.0 3.3e-20 72.3 1.0 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD66864.1 - 0.0045 17.1 12.5 0.0045 17.1 12.5 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RTA1 PF04479.13 EMD66865.1 - 2.9e-27 95.6 1.1 4.6e-27 95.0 0.6 1.5 1 1 0 1 1 1 1 RTA1 like protein PAN_4 PF14295.6 EMD66866.1 - 2.9e-15 55.9 4.5 3.1e-08 33.4 0.1 3.0 3 0 0 3 3 3 2 PAN domain PAN_3 PF08277.12 EMD66866.1 - 7.4e-05 22.5 1.2 0.34 10.7 0.0 2.6 2 0 0 2 2 2 2 PAN-like domain PAN_2 PF08276.11 EMD66866.1 - 0.11 12.6 3.9 0.25 11.5 0.5 2.6 2 0 0 2 2 2 0 PAN-like domain CARDB PF07705.11 EMD66866.1 - 1.1 9.5 7.9 4.8 7.5 0.1 2.5 2 0 0 2 2 2 0 CARDB F-box-like_2 PF13013.6 EMD66869.1 - 0.0023 17.9 0.0 0.025 14.6 0.0 2.3 2 1 0 2 2 2 1 F-box-like domain adh_short PF00106.25 EMD66871.1 - 1.2e-29 103.2 0.0 1.5e-29 102.8 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD66871.1 - 1.2e-22 80.6 0.0 1.6e-22 80.2 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD66871.1 - 0.0021 18.0 0.0 0.0079 16.1 0.0 1.8 2 0 0 2 2 2 1 KR domain p450 PF00067.22 EMD66874.1 - 1.1e-47 162.9 0.0 1.3e-47 162.7 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Caps_synth PF05704.12 EMD66874.1 - 0.13 11.6 0.0 0.19 11.1 0.0 1.2 1 0 0 1 1 1 0 Capsular polysaccharide synthesis protein DEAD PF00270.29 EMD66875.1 - 1.7e-17 63.8 0.0 3.7e-17 62.6 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 EMD66875.1 - 2.2e-13 50.6 0.0 7.3e-13 48.9 0.0 1.9 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EMD66875.1 - 5.6e-07 29.9 0.2 1.3e-05 25.5 0.0 2.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain PhoH PF02562.16 EMD66875.1 - 0.018 14.5 0.0 0.035 13.6 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein AAA_22 PF13401.6 EMD66876.1 - 0.00098 19.4 0.1 0.66 10.2 0.0 2.6 2 0 0 2 2 2 2 AAA domain DUF853 PF05872.12 EMD66876.1 - 0.0016 17.1 0.0 0.0024 16.5 0.0 1.2 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF853) Zot PF05707.12 EMD66876.1 - 0.0036 17.0 0.0 0.0097 15.6 0.0 1.7 2 0 0 2 2 2 1 Zonular occludens toxin (Zot) HNF-1_N PF04814.13 EMD66876.1 - 0.015 16.0 0.7 0.026 15.1 0.7 1.3 1 0 0 1 1 1 0 Hepatocyte nuclear factor 1 (HNF-1), N terminus DUF87 PF01935.17 EMD66876.1 - 0.056 13.5 0.4 0.59 10.2 0.3 2.5 1 1 0 1 1 1 0 Helicase HerA, central domain ECF_trnsprt PF12822.7 EMD66878.1 - 4.3 7.4 29.0 5.5 7.1 4.3 2.2 1 1 1 2 2 2 0 ECF transporter, substrate-specific component FAD_binding_3 PF01494.19 EMD66880.1 - 5.4e-15 55.5 0.0 1.2e-14 54.3 0.0 1.5 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.24 EMD66880.1 - 1.6e-08 34.5 0.5 0.00029 20.5 0.0 2.6 3 1 0 3 3 3 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EMD66880.1 - 1e-05 24.9 0.0 0.07 12.4 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EMD66880.1 - 0.00087 18.5 0.3 0.0028 16.8 0.1 1.8 2 0 0 2 2 2 1 FAD binding domain HI0933_like PF03486.14 EMD66880.1 - 0.0075 15.0 0.1 0.023 13.4 0.0 1.7 2 0 0 2 2 2 1 HI0933-like protein FAD_oxidored PF12831.7 EMD66880.1 - 0.01 15.2 0.0 0.016 14.6 0.0 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase GIDA PF01134.22 EMD66880.1 - 0.02 14.0 0.1 1.1 8.3 0.1 2.1 2 0 0 2 2 2 0 Glucose inhibited division protein A Trp_halogenase PF04820.14 EMD66880.1 - 0.046 12.6 0.2 5.6 5.7 0.0 2.2 2 0 0 2 2 2 0 Tryptophan halogenase Pyr_redox_3 PF13738.6 EMD66880.1 - 0.051 12.8 0.0 0.23 10.7 0.0 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EMD66881.1 - 6.5e-28 97.8 0.2 5.6e-14 51.8 0.0 2.4 2 1 0 2 2 2 2 Tryptophan halogenase FAD_binding_3 PF01494.19 EMD66881.1 - 2.4e-13 50.1 0.0 9.2e-13 48.1 0.0 2.0 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EMD66881.1 - 5.5e-06 25.8 0.1 1.1e-05 24.8 0.1 1.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EMD66881.1 - 1e-05 24.4 0.3 5.6e-05 22.0 0.0 2.0 2 0 0 2 2 2 1 HI0933-like protein NAD_binding_8 PF13450.6 EMD66881.1 - 1.3e-05 25.3 0.5 3.6e-05 23.9 0.1 2.0 2 0 0 2 2 1 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 EMD66881.1 - 1.3e-05 24.7 0.6 1.3e-05 24.7 0.6 1.8 2 1 0 2 2 2 1 FAD dependent oxidoreductase GIDA PF01134.22 EMD66881.1 - 3.6e-05 23.0 0.4 8e-05 21.9 0.0 1.7 2 0 0 2 2 2 1 Glucose inhibited division protein A FAD_binding_2 PF00890.24 EMD66881.1 - 0.00013 21.2 0.0 0.00024 20.3 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 EMD66881.1 - 0.00044 19.9 0.1 0.001 18.8 0.1 1.6 2 0 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.17 EMD66881.1 - 0.00083 18.7 0.3 0.0036 16.6 0.0 2.2 2 0 0 2 2 2 1 Thi4 family Lycopene_cycl PF05834.12 EMD66881.1 - 0.0024 17.0 0.1 0.016 14.3 0.0 2.1 2 0 0 2 2 2 1 Lycopene cyclase protein TetR_C_35 PF18556.1 EMD66881.1 - 0.0053 16.9 0.1 0.011 15.9 0.1 1.5 1 0 0 1 1 1 1 Bacterial Tetracyclin repressor, C-terminal domain Pyr_redox PF00070.27 EMD66881.1 - 0.024 15.2 0.0 0.068 13.7 0.0 1.8 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 EMD66881.1 - 0.035 13.4 0.0 0.073 12.4 0.0 1.5 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain ketoacyl-synt PF00109.26 EMD66882.1 - 8.1e-71 238.6 1.1 1.1e-70 238.1 0.0 1.8 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain SAT PF16073.5 EMD66882.1 - 1.6e-49 168.8 0.4 1e-46 159.6 0.0 2.8 3 0 0 3 3 3 2 Starter unit:ACP transacylase in aflatoxin biosynthesis Acyl_transf_1 PF00698.21 EMD66882.1 - 2.6e-40 138.9 0.0 5.5e-40 137.8 0.0 1.5 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EMD66882.1 - 3.6e-35 120.5 1.3 1.1e-34 119.0 1.3 1.9 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain PP-binding PF00550.25 EMD66882.1 - 2.4e-13 50.2 0.1 1.7e-12 47.5 0.3 2.4 2 0 0 2 2 2 1 Phosphopantetheine attachment site KAsynt_C_assoc PF16197.5 EMD66882.1 - 1.3e-11 44.9 0.0 4.7e-11 43.1 0.0 1.9 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension PS-DH PF14765.6 EMD66882.1 - 1.1e-08 34.7 0.0 2.3e-08 33.7 0.0 1.5 1 0 0 1 1 1 1 Polyketide synthase dehydratase Thiolase_N PF00108.23 EMD66882.1 - 0.0018 17.7 0.0 0.0049 16.3 0.0 1.7 1 0 0 1 1 1 1 Thiolase, N-terminal domain Saccharop_dh_N PF04455.12 EMD66882.1 - 0.14 12.5 0.2 0.92 9.9 0.0 2.4 2 1 1 3 3 3 0 LOR/SDH bifunctional enzyme conserved region Lactamase_B PF00753.27 EMD66883.1 - 1.6e-16 60.9 3.1 1.6e-14 54.4 3.1 2.3 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EMD66883.1 - 0.0003 20.4 0.2 0.00073 19.1 0.1 1.8 2 1 0 2 2 2 1 Beta-lactamase superfamily domain EthD PF07110.11 EMD66884.1 - 3e-20 73.2 0.5 3.8e-20 72.8 0.5 1.1 1 0 0 1 1 1 1 EthD domain MmlI PF09448.10 EMD66884.1 - 0.013 16.0 0.1 0.018 15.5 0.1 1.3 1 0 0 1 1 1 0 Methylmuconolactone methyl-isomerase Questin_oxidase PF14027.6 EMD66885.1 - 7.8e-82 275.5 0.2 9.4e-82 275.3 0.2 1.1 1 0 0 1 1 1 1 Questin oxidase-like DUF1139 PF06599.11 EMD66885.1 - 0.15 11.5 0.1 1.1 8.6 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1139) Scytalone_dh PF02982.14 EMD66886.1 - 1.1e-55 187.7 0.0 1.3e-55 187.5 0.0 1.0 1 0 0 1 1 1 1 Scytalone dehydratase SnoaL_4 PF13577.6 EMD66886.1 - 7.9e-06 26.0 0.1 1.2e-05 25.5 0.1 1.3 1 0 0 1 1 1 1 SnoaL-like domain Peptidase_C71 PF12386.8 EMD66886.1 - 0.1 12.3 0.0 0.15 11.7 0.0 1.2 1 0 0 1 1 1 0 Pseudomurein endo-isopeptidase Pei SnoaL_2 PF12680.7 EMD66887.1 - 1.6e-05 25.5 0.0 2.1e-05 25.1 0.0 1.2 1 0 0 1 1 1 1 SnoaL-like domain SnoaL_3 PF13474.6 EMD66887.1 - 0.018 15.3 0.0 0.044 14.0 0.0 1.6 1 1 1 2 2 2 0 SnoaL-like domain SnoaL PF07366.12 EMD66887.1 - 0.049 13.4 0.0 0.062 13.1 0.0 1.3 1 1 0 1 1 1 0 SnoaL-like polyketide cyclase PRTase_3 PF15610.6 EMD66888.1 - 0.021 14.1 0.0 0.031 13.5 0.0 1.2 1 0 0 1 1 1 0 PRTase ComF-like Methyltransf_11 PF08241.12 EMD66889.1 - 1.1e-16 61.2 0.1 2.4e-16 60.2 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMD66889.1 - 1.7e-14 54.3 0.1 4.7e-14 52.9 0.1 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMD66889.1 - 2.9e-11 44.0 0.0 6.7e-11 42.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMD66889.1 - 3.8e-10 39.8 0.0 5.7e-10 39.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EMD66889.1 - 1.4e-06 28.3 0.0 2.1e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EMD66889.1 - 0.00082 18.8 0.0 0.0087 15.4 0.0 2.0 1 1 1 2 2 2 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 EMD66889.1 - 0.0038 16.8 0.1 0.007 15.9 0.1 1.4 1 1 0 1 1 1 1 Methyltransferase small domain ADH_zinc_N PF00107.26 EMD66889.1 - 0.0057 16.6 0.2 0.0089 16.0 0.2 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase PG_isomerase_N PF18353.1 EMD66889.1 - 0.35 11.3 2.4 7.9 6.9 0.5 2.4 2 1 0 2 2 2 0 Phosphoglucose isomerase N-terminal domain NAD_binding_10 PF13460.6 EMD66890.1 - 1.7e-21 76.9 0.0 2e-21 76.7 0.0 1.1 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EMD66890.1 - 5.8e-06 26.0 0.0 9.2e-06 25.4 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family 3Beta_HSD PF01073.19 EMD66890.1 - 5e-05 22.4 0.0 0.00011 21.4 0.0 1.5 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Semialdhyde_dh PF01118.24 EMD66890.1 - 9.6e-05 22.8 0.0 0.00016 22.1 0.0 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Epimerase PF01370.21 EMD66890.1 - 0.0012 18.3 0.0 0.002 17.6 0.0 1.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family DapB_N PF01113.20 EMD66890.1 - 0.015 15.4 0.0 0.025 14.7 0.0 1.4 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus NAD_binding_4 PF07993.12 EMD66890.1 - 0.037 13.2 0.0 0.075 12.2 0.0 1.5 1 1 0 1 1 1 0 Male sterility protein KR PF08659.10 EMD66890.1 - 0.056 13.3 0.0 0.093 12.6 0.0 1.3 1 0 0 1 1 1 0 KR domain DUF1772 PF08592.11 EMD66891.1 - 7.8e-28 97.5 4.1 9.5e-28 97.2 4.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1772) 7TM_GPCR_Srsx PF10320.9 EMD66891.1 - 0.022 14.1 0.1 0.024 14.0 0.1 1.2 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srsx adh_short_C2 PF13561.6 EMD66892.1 - 3.8e-56 190.3 2.3 4.9e-56 189.9 2.3 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EMD66892.1 - 1.9e-49 167.8 1.7 2.3e-49 167.5 1.7 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EMD66892.1 - 4.3e-15 56.1 2.0 5.6e-15 55.7 2.0 1.1 1 0 0 1 1 1 1 KR domain Peripla_BP_6 PF13458.6 EMD66892.1 - 0.013 15.2 0.9 0.033 13.8 0.5 1.8 2 0 0 2 2 2 0 Periplasmic binding protein DUF460 PF04312.13 EMD66892.1 - 0.02 14.6 0.3 0.05 13.3 0.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF460) Epimerase PF01370.21 EMD66892.1 - 0.029 13.9 0.3 0.068 12.6 0.3 1.6 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family DUF1776 PF08643.10 EMD66892.1 - 0.16 11.3 0.0 0.22 10.9 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) DUF4267 PF14087.6 EMD66893.1 - 3.7e-11 43.1 5.0 4e-11 43.0 3.8 1.6 1 1 1 2 2 2 1 Domain of unknown function (DUF4267) FAD_binding_3 PF01494.19 EMD66894.1 - 1.3e-15 57.5 0.1 3.1e-15 56.3 0.1 1.7 1 1 0 1 1 1 1 FAD binding domain SE PF08491.10 EMD66894.1 - 0.0018 17.4 0.0 0.86 8.6 0.0 2.2 2 0 0 2 2 2 2 Squalene epoxidase Pyr_redox_2 PF07992.14 EMD66894.1 - 0.013 14.7 0.2 0.091 12.0 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EMD66894.1 - 0.034 13.0 0.7 8.1 5.2 0.0 3.1 3 0 0 3 3 3 0 Tryptophan halogenase NAD_binding_9 PF13454.6 EMD66894.1 - 0.039 13.9 0.1 9.5 6.2 0.0 2.4 2 0 0 2 2 2 0 FAD-NAD(P)-binding Amino_oxidase PF01593.24 EMD66894.1 - 0.11 11.7 0.0 0.22 10.8 0.0 1.3 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase Zn_clus PF00172.18 EMD66895.1 - 0.0067 16.5 13.2 0.017 15.2 13.2 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF3920 PF13058.6 EMD66895.1 - 0.019 15.2 0.1 0.034 14.4 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3920) MFS_1 PF07690.16 EMD66896.1 - 7.9e-37 127.0 49.7 7.9e-37 127.0 49.7 1.9 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EMD66896.1 - 7.2e-09 34.6 26.0 2e-08 33.1 25.7 1.8 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) AflR PF08493.10 EMD66897.1 - 3.6e-09 36.5 22.6 1.2e-07 31.6 22.6 2.5 1 1 0 1 1 1 1 Aflatoxin regulatory protein Zn_clus PF00172.18 EMD66897.1 - 5.3e-05 23.3 7.9 8.8e-05 22.5 7.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF1090 PF06476.12 EMD66897.1 - 0.059 13.5 1.4 0.19 11.9 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1090) Sugar_tr PF00083.24 EMD66898.1 - 3.3e-60 204.2 21.0 3.7e-60 204.1 21.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD66898.1 - 3.1e-16 59.3 22.1 3.1e-16 59.3 22.1 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily DUF3382 PF11862.8 EMD66898.1 - 3.7 7.9 9.5 2.3 8.6 4.7 3.0 1 1 1 2 2 2 0 Domain of unknown function (DUF3382) Caleosin PF05042.13 EMD66900.1 - 9e-80 266.5 0.2 1.1e-79 266.2 0.2 1.1 1 0 0 1 1 1 1 Caleosin related protein Big_7 PF17957.1 EMD66901.1 - 0.077 13.8 0.1 0.13 13.0 0.1 1.5 1 0 0 1 1 1 0 Bacterial Ig domain Pyr_redox_2 PF07992.14 EMD66902.1 - 2.9e-40 138.3 0.0 3.8e-40 138.0 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EMD66902.1 - 5.4e-18 65.3 0.1 1.1e-14 54.8 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EMD66902.1 - 1.2e-08 34.5 0.0 1.4e-06 27.8 0.0 2.2 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Trp_halogenase PF04820.14 EMD66902.1 - 3.4e-07 29.5 0.1 0.045 12.6 0.0 4.0 3 1 1 4 4 4 2 Tryptophan halogenase Pyr_redox_3 PF13738.6 EMD66902.1 - 6e-07 29.0 0.0 0.0012 18.1 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EMD66902.1 - 2.3e-06 27.4 0.0 0.035 13.7 0.0 3.8 4 0 0 4 4 4 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EMD66902.1 - 3.3e-05 24.0 0.0 0.032 14.5 0.0 2.5 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 EMD66902.1 - 0.0012 17.9 0.0 0.48 9.4 0.0 3.0 3 0 0 3 3 3 1 Lycopene cyclase protein TrkA_N PF02254.18 EMD66902.1 - 0.0021 18.3 0.0 0.81 10.0 0.0 3.1 3 0 0 3 3 3 1 TrkA-N domain HI0933_like PF03486.14 EMD66902.1 - 0.0077 15.0 0.0 7.1 5.2 0.0 3.2 3 0 0 3 3 3 1 HI0933-like protein NAD_binding_9 PF13454.6 EMD66902.1 - 0.018 15.1 0.3 6.7 6.7 0.0 3.7 3 1 1 4 4 4 0 FAD-NAD(P)-binding Leo1 PF04004.13 EMD66902.1 - 0.18 11.6 0.0 0.41 10.5 0.0 1.6 1 0 0 1 1 1 0 Leo1-like protein ADH_zinc_N PF00107.26 EMD66903.1 - 0.032 14.2 0.0 0.055 13.5 0.0 1.3 1 0 0 1 1 1 0 Zinc-binding dehydrogenase TauD PF02668.16 EMD66904.1 - 8.4e-30 104.5 0.1 1.1e-29 104.0 0.1 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family AA_permease_2 PF13520.6 EMD66905.1 - 9.6e-73 245.4 37.3 1.2e-72 245.1 37.3 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EMD66905.1 - 7.7e-14 51.2 34.7 1.2e-13 50.6 34.7 1.3 1 0 0 1 1 1 1 Amino acid permease TMEM40 PF15817.5 EMD66905.1 - 5 6.9 7.8 6 6.7 0.1 2.9 3 0 0 3 3 3 0 Transmembrane protein 40 family SNF PF00209.18 EMD66907.1 - 9.4e-76 255.6 34.7 3.3e-75 253.8 29.3 2.8 2 1 0 2 2 2 1 Sodium:neurotransmitter symporter family DUF3810 PF12725.7 EMD66907.1 - 1.1 8.6 4.9 0.25 10.7 0.8 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3810) zf-GRF PF06839.12 EMD66909.1 - 0.19 11.8 1.3 0.44 10.7 1.0 1.8 2 0 0 2 2 2 0 GRF zinc finger Glyco_transf_34 PF05637.12 EMD66910.1 - 8.4e-27 94.4 3.0 4.9e-25 88.6 3.0 2.0 1 1 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family Nucleotid_trans PF03407.16 EMD66910.1 - 0.0073 16.3 0.1 0.015 15.3 0.1 1.4 1 1 0 1 1 1 1 Nucleotide-diphospho-sugar transferase PRIMA1 PF16101.5 EMD66910.1 - 0.13 12.3 8.6 0.22 11.6 8.6 1.3 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 CAP_N PF01213.19 EMD66910.1 - 3.2 7.1 9.9 4.8 6.6 9.9 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Mito_fiss_reg PF05308.11 EMD66910.1 - 5.8 6.9 6.2 8.8 6.3 6.2 1.2 1 0 0 1 1 1 0 Mitochondrial fission regulator Beta-lactamase PF00144.24 EMD66911.1 - 8.4e-29 100.8 0.2 2e-28 99.6 0.2 1.5 1 1 0 1 1 1 1 Beta-lactamase Corona_M PF01635.18 EMD66913.1 - 0.024 14.0 0.4 0.036 13.4 0.4 1.2 1 0 0 1 1 1 0 Coronavirus M matrix/glycoprotein 7tm_2 PF00002.24 EMD66914.1 - 5.8e-05 22.5 12.4 0.00017 21.0 12.4 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (Secretin family) 2-Hacid_dh_C PF02826.19 EMD66915.1 - 3.2e-46 156.9 0.1 1.4e-29 102.8 0.0 2.5 3 0 0 3 3 3 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EMD66915.1 - 0.002 17.8 0.0 0.0025 17.5 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 EMD66915.1 - 0.0026 18.0 0.0 0.0042 17.3 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase XdhC_C PF13478.6 EMD66915.1 - 0.0054 17.2 0.0 0.011 16.2 0.0 1.5 1 1 0 1 1 1 1 XdhC Rossmann domain IlvN PF07991.12 EMD66915.1 - 0.011 15.4 0.1 0.025 14.2 0.1 1.6 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain 3HCDH_N PF02737.18 EMD66915.1 - 0.028 14.3 0.0 0.063 13.2 0.0 1.6 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Gp_dh_N PF00044.24 EMD66915.1 - 0.057 13.8 0.1 0.21 11.9 0.0 2.0 2 0 0 2 2 2 0 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain F420_oxidored PF03807.17 EMD66915.1 - 0.059 14.0 0.0 0.13 12.8 0.0 1.7 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent AlaDh_PNT_C PF01262.21 EMD66915.1 - 0.11 11.8 0.0 0.21 10.8 0.0 1.5 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Oxidored_nitro PF00148.19 EMD66915.1 - 0.14 10.9 0.0 0.18 10.5 0.0 1.2 1 0 0 1 1 1 0 Nitrogenase component 1 type Oxidoreductase DUF846 PF05832.12 EMD66916.1 - 2.5e-50 170.1 10.1 2.9e-50 169.9 10.1 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF846) Mcp5_PH PF12814.7 EMD66916.1 - 0.086 13.0 0.0 0.15 12.2 0.0 1.3 1 0 0 1 1 1 0 Meiotic cell cortex C-terminal pleckstrin homology DUF1700 PF08006.11 EMD66916.1 - 5.2 6.6 9.6 1.8 8.1 0.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1700) HpcH_HpaI PF03328.14 EMD66917.1 - 2.9e-45 154.1 0.0 4e-45 153.6 0.0 1.2 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family C-C_Bond_Lyase PF15617.6 EMD66917.1 - 5.8e-14 52.0 0.1 8.9e-07 28.4 0.0 2.1 2 0 0 2 2 2 2 C-C_Bond_Lyase of the TIM-Barrel fold Methyltransf_28 PF02636.17 EMD66918.1 - 4.7e-37 128.0 0.0 6.5e-37 127.6 0.0 1.2 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase PALP PF00291.25 EMD66919.1 - 5.6e-64 216.4 0.1 7e-64 216.1 0.1 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme GHMP_kinases_C PF08544.13 EMD66919.1 - 0.045 14.1 0.1 14 6.2 0.0 3.3 3 0 0 3 3 3 0 GHMP kinases C terminal Abhydrolase_4 PF08386.10 EMD66921.1 - 5.4e-24 84.3 0.0 1.3e-23 83.1 0.0 1.6 1 0 0 1 1 1 1 TAP-like protein Abhydrolase_1 PF00561.20 EMD66921.1 - 8.2e-20 71.5 0.0 2.4e-06 27.4 0.0 3.2 3 0 0 3 3 3 3 alpha/beta hydrolase fold RRM_1 PF00076.22 EMD66922.1 - 4.8e-23 80.8 0.0 6e-23 80.5 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EMD66922.1 - 0.00069 19.7 0.0 0.0011 19.1 0.0 1.4 1 1 0 1 1 1 1 RNA recognition motif DbpA PF03880.15 EMD66922.1 - 0.12 12.4 0.0 0.17 11.9 0.0 1.2 1 0 0 1 1 1 0 DbpA RNA binding domain Pyrophosphatase PF00719.19 EMD66924.1 - 5.4e-59 198.6 0.1 7e-59 198.2 0.1 1.1 1 0 0 1 1 1 1 Inorganic pyrophosphatase MRP_L53 PF10780.9 EMD66925.1 - 9.8e-23 80.1 0.1 1.5e-22 79.5 0.1 1.3 1 0 0 1 1 1 1 39S ribosomal protein L53/MRP-L53 LBR_tudor PF09465.10 EMD66925.1 - 0.16 11.8 0.0 0.22 11.3 0.0 1.2 1 0 0 1 1 1 0 Lamin-B receptor of TUDOR domain Sec20 PF03908.13 EMD66926.1 - 2e-16 59.6 1.4 2e-16 59.6 1.4 2.0 2 0 0 2 2 2 1 Sec20 AAA_11 PF13086.6 EMD66926.1 - 0.066 13.0 10.3 0.037 13.8 3.4 2.8 2 1 0 2 2 2 0 AAA domain Cys_Met_Meta_PP PF01053.20 EMD66927.1 - 1.9e-140 467.7 0.2 2.2e-140 467.5 0.2 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 EMD66927.1 - 3.1e-10 39.8 0.1 5.3e-10 39.0 0.1 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 EMD66927.1 - 1e-06 28.3 0.1 1.7e-06 27.6 0.1 1.4 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 EMD66927.1 - 1.2e-05 24.5 0.4 2.1e-05 23.7 0.1 1.5 2 0 0 2 2 2 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 EMD66927.1 - 0.049 12.9 0.2 0.15 11.3 0.1 1.7 1 1 0 1 1 1 0 Beta-eliminating lyase Atg14 PF10186.9 EMD66928.1 - 1.2e-85 287.5 0.2 1.5e-85 287.1 0.2 1.1 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 RasGAP_C PF03836.15 EMD66928.1 - 0.0034 17.5 5.3 0.0039 17.3 3.2 2.0 2 0 0 2 2 2 1 RasGAP C-terminus TMPIT PF07851.13 EMD66928.1 - 0.094 11.9 4.6 0.14 11.4 4.6 1.2 1 0 0 1 1 1 0 TMPIT-like protein ArnB_C PF18677.1 EMD66928.1 - 0.099 12.8 7.1 0.22 11.6 6.2 2.1 1 1 0 1 1 1 0 Archaellum regulatory network B, C-terminal domain YabA PF06156.13 EMD66928.1 - 2.1 9.0 5.2 9.1 7.0 1.3 2.4 2 0 0 2 2 2 0 Initiation control protein YabA PRKG1_interact PF15898.5 EMD66928.1 - 3.8 8.5 10.4 4.2 8.3 8.7 2.0 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain Pyr_redox_2 PF07992.14 EMD66930.1 - 1.9e-46 158.6 1.6 2.3e-46 158.4 1.6 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EMD66930.1 - 1.2e-21 77.3 0.4 2.9e-18 66.2 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EMD66930.1 - 3.5e-16 59.5 1.1 2.6e-14 53.5 0.3 2.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EMD66930.1 - 8.2e-06 25.2 1.0 0.0011 18.2 0.1 2.7 2 1 0 3 3 3 1 Thi4 family GIDA PF01134.22 EMD66930.1 - 1.7e-05 24.1 4.9 0.00047 19.4 0.4 3.6 3 2 1 4 4 4 1 Glucose inhibited division protein A DAO PF01266.24 EMD66930.1 - 2.1e-05 24.3 1.6 1.6 8.2 0.7 3.4 3 1 0 3 3 3 3 FAD dependent oxidoreductase K_oxygenase PF13434.6 EMD66930.1 - 2.9e-05 23.4 0.6 0.017 14.3 0.0 2.9 2 1 1 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) FAD_oxidored PF12831.7 EMD66930.1 - 5.7e-05 22.7 0.2 5.7e-05 22.7 0.2 2.5 2 1 1 3 3 3 1 FAD dependent oxidoreductase HI0933_like PF03486.14 EMD66930.1 - 0.00015 20.6 0.4 0.022 13.5 0.3 3.1 3 0 0 3 3 3 1 HI0933-like protein NAD_binding_8 PF13450.6 EMD66930.1 - 0.0017 18.6 0.3 0.22 11.8 0.2 2.6 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain NAD_binding_7 PF13241.6 EMD66930.1 - 0.0066 16.9 0.7 0.09 13.2 0.0 2.6 2 1 0 2 2 2 1 Putative NAD(P)-binding FAD_binding_2 PF00890.24 EMD66930.1 - 0.0069 15.5 8.7 0.017 14.2 1.2 3.6 2 1 2 4 4 4 1 FAD binding domain Trp_halogenase PF04820.14 EMD66930.1 - 0.037 12.9 0.3 0.7 8.7 0.1 2.5 3 0 0 3 3 3 0 Tryptophan halogenase Shikimate_DH PF01488.20 EMD66930.1 - 0.098 12.7 0.1 4.7 7.3 0.0 2.9 3 0 0 3 3 3 0 Shikimate / quinate 5-dehydrogenase FAD_binding_3 PF01494.19 EMD66930.1 - 0.11 11.7 1.9 0.93 8.7 0.1 2.3 2 1 1 3 3 3 0 FAD binding domain WD40 PF00400.32 EMD66931.1 - 2.4e-05 25.0 0.5 0.24 12.3 0.0 4.3 4 0 0 4 4 4 2 WD domain, G-beta repeat CPSF_A PF03178.15 EMD66931.1 - 0.0016 17.8 0.0 0.0091 15.3 0.1 2.2 1 1 0 1 1 1 1 CPSF A subunit region Lactonase PF10282.9 EMD66931.1 - 0.1 11.9 0.0 0.18 11.1 0.0 1.4 1 0 0 1 1 1 0 Lactonase, 7-bladed beta-propeller Ribosomal_L10 PF00466.20 EMD66932.1 - 4e-25 87.9 0.1 8.2e-25 86.9 0.1 1.5 1 0 0 1 1 1 1 Ribosomal protein L10 Ribosomal_60s PF00428.19 EMD66932.1 - 1.7e-23 83.0 3.5 1e-22 80.5 3.0 2.2 2 0 0 2 2 2 1 60s Acidic ribosomal protein RL10P_insert PF17777.1 EMD66932.1 - 1.6e-21 76.1 0.0 3.2e-21 75.1 0.0 1.6 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P Pox_Ag35 PF03286.14 EMD66932.1 - 0.21 11.4 1.1 95 2.7 0.0 3.6 4 0 0 4 4 4 0 Pox virus Ag35 surface protein FR47 PF08445.10 EMD66933.1 - 4e-05 23.5 0.0 7.2e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein GNAT_acetyltran PF12746.7 EMD66933.1 - 0.18 11.4 0.0 0.28 10.7 0.0 1.2 1 0 0 1 1 1 0 GNAT acetyltransferase Mito_carr PF00153.27 EMD66935.1 - 6.3e-64 212.0 3.7 1.2e-20 73.3 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 EMD66935.1 - 0.13 11.4 1.2 1 8.5 0.0 2.9 4 0 0 4 4 4 0 Gammaproteobacterial serine protease zf-B_box PF00643.24 EMD66936.1 - 0.0071 16.5 2.8 0.011 15.9 2.8 1.2 1 0 0 1 1 1 1 B-box zinc finger Thioredoxin_4 PF13462.6 EMD66937.1 - 4.6e-07 30.2 0.0 1.1e-06 28.9 0.0 1.6 1 1 0 1 1 1 1 Thioredoxin DSBA PF01323.20 EMD66937.1 - 0.026 14.3 4.2 1.5 8.6 0.1 3.0 2 1 0 2 2 2 0 DSBA-like thioredoxin domain Sin3a_C PF16879.5 EMD66938.1 - 8.1e-68 229.2 11.0 8.1e-68 229.2 11.0 2.9 3 0 0 3 3 3 1 C-terminal domain of Sin3a protein PAH PF02671.21 EMD66938.1 - 5e-43 145.0 3.5 1.8e-17 63.2 0.5 4.3 3 1 1 4 4 4 3 Paired amphipathic helix repeat Sin3_corepress PF08295.12 EMD66938.1 - 1.1e-39 134.5 0.1 4.2e-39 132.6 0.1 2.1 1 0 0 1 1 1 1 Sin3 family co-repressor Glyco_hydro_3_C PF01915.22 EMD66939.1 - 2e-64 217.3 0.0 4.6e-64 216.1 0.0 1.6 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 EMD66939.1 - 1.5e-52 179.0 0.0 2.4e-52 178.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain PA14 PF07691.12 EMD66939.1 - 1.2e-21 77.0 0.0 2.1e-21 76.3 0.0 1.4 1 0 0 1 1 1 1 PA14 domain Fn3-like PF14310.6 EMD66939.1 - 8e-20 70.7 0.1 1.8e-19 69.6 0.1 1.6 1 0 0 1 1 1 1 Fibronectin type III-like domain Myosin_head PF00063.21 EMD66940.1 - 1.8e-243 809.7 3.7 2.2e-243 809.4 3.7 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Pkinase PF00069.25 EMD66940.1 - 1.3e-61 208.3 0.0 2.2e-61 207.5 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Myosin_TH1 PF06017.13 EMD66940.1 - 6e-52 176.0 0.0 1.1e-51 175.2 0.0 1.5 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding Pkinase_Tyr PF07714.17 EMD66940.1 - 5.3e-42 143.9 0.0 8.9e-42 143.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase SH3_1 PF00018.28 EMD66940.1 - 1.9e-12 46.6 0.1 4.3e-12 45.4 0.1 1.7 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EMD66940.1 - 7.9e-11 41.6 0.0 2.1e-10 40.3 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EMD66940.1 - 4.9e-09 35.7 0.0 1.2e-08 34.5 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain POLO_box PF00659.18 EMD66940.1 - 1.6e-07 31.4 0.7 0.0006 19.9 0.1 2.6 2 0 0 2 2 2 2 POLO box duplicated region Kinase-like PF14531.6 EMD66940.1 - 5.3e-06 26.0 0.0 1e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 Kinase-like IQ PF00612.27 EMD66940.1 - 0.0017 17.9 4.3 1.2 9.1 0.0 2.8 2 0 0 2 2 2 2 IQ calmodulin-binding motif AAA_22 PF13401.6 EMD66940.1 - 0.029 14.7 0.0 0.09 13.1 0.0 1.9 1 0 0 1 1 1 0 AAA domain Kdo PF06293.14 EMD66940.1 - 0.043 13.2 0.0 0.084 12.2 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family AAA_16 PF13191.6 EMD66940.1 - 0.072 13.5 0.0 0.26 11.7 0.0 1.9 1 0 0 1 1 1 0 AAA ATPase domain Pkinase_fungal PF17667.1 EMD66940.1 - 0.073 11.8 0.0 0.16 10.7 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase Hpr_kinase_C PF07475.12 EMD66940.1 - 0.13 11.8 0.6 4.7 6.7 0.0 2.5 2 0 0 2 2 2 0 HPr Serine kinase C-terminal domain Haspin_kinase PF12330.8 EMD66940.1 - 0.2 10.5 0.0 0.33 9.8 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain OPA3 PF07047.12 EMD66941.1 - 3.3e-43 146.4 11.4 7.2e-43 145.3 11.4 1.6 1 1 0 1 1 1 1 Optic atrophy 3 protein (OPA3) HDV_ag PF01517.18 EMD66941.1 - 0.012 15.4 1.0 0.012 15.4 1.0 2.3 2 1 0 2 2 2 0 Hepatitis delta virus delta antigen EAP30 PF04157.16 EMD66941.1 - 0.017 14.4 1.2 0.63 9.3 0.0 2.6 2 1 0 2 2 2 0 EAP30/Vps36 family NicO PF03824.16 EMD66941.1 - 0.052 12.9 0.0 0.081 12.3 0.0 1.2 1 0 0 1 1 1 0 High-affinity nickel-transport protein Med11 PF10280.9 EMD66941.1 - 0.098 13.1 3.4 0.64 10.5 0.1 2.8 2 2 0 2 2 2 0 Mediator complex protein DUF1003 PF06210.11 EMD66941.1 - 0.14 12.2 0.1 0.14 12.2 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1003) APG6_N PF17675.1 EMD66941.1 - 9.3 6.8 14.2 0.19 12.2 1.0 2.5 3 0 0 3 3 3 0 Apg6 coiled-coil region Glycoprotein_G PF00802.19 EMD66942.1 - 0.099 12.0 1.9 0.11 11.9 1.1 1.4 1 1 0 1 1 1 0 Pneumovirus attachment glycoprotein G DUF3712 PF12505.8 EMD66943.1 - 5.4e-35 120.4 5.6 6.4e-35 120.1 1.3 2.4 3 0 0 3 3 3 1 Protein of unknown function (DUF3712) LEA_2 PF03168.13 EMD66943.1 - 0.0062 17.0 0.0 0.5 10.9 0.0 2.4 2 0 0 2 2 2 1 Late embryogenesis abundant protein DUF4187 PF13821.6 EMD66944.1 - 6.6e-21 73.8 0.6 1.7e-20 72.5 0.6 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4187) G-patch PF01585.23 EMD66944.1 - 2.8e-13 49.5 0.2 5.1e-13 48.7 0.2 1.5 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 EMD66944.1 - 0.049 13.7 0.3 0.049 13.7 0.3 2.5 2 1 1 3 3 3 0 G-patch domain PCEMA1 PF07418.11 EMD66944.1 - 7.5 6.0 10.7 1.2 8.6 7.2 1.4 2 0 0 2 2 2 0 Acidic phosphoprotein precursor PCEMA1 ORC3_N PF07034.11 EMD66945.1 - 2.8e-37 128.6 0.2 6.2e-36 124.2 0.0 2.5 2 1 0 2 2 2 1 Origin recognition complex (ORC) subunit 3 N-terminus ORC_WH_C PF18137.1 EMD66945.1 - 9.7e-29 100.2 0.0 4.7e-16 59.1 0.0 2.6 1 1 1 2 2 2 2 Origin recognition complex winged helix C-terminal RasGAP_C PF03836.15 EMD66945.1 - 0.0065 16.6 0.7 0.054 13.6 0.1 2.4 2 0 0 2 2 2 1 RasGAP C-terminus Sec3_C PF09763.9 EMD66945.1 - 0.059 11.7 0.1 0.13 10.6 0.1 1.5 1 0 0 1 1 1 0 Exocyst complex component Sec3 3-HAO PF06052.12 EMD66946.1 - 1.4e-62 209.8 0.0 1.8e-62 209.5 0.0 1.1 1 0 0 1 1 1 1 3-hydroxyanthranilic acid dioxygenase AraC_binding PF02311.19 EMD66946.1 - 2e-05 24.5 0.1 3.5e-05 23.7 0.1 1.3 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_2 PF07883.11 EMD66946.1 - 2.7e-05 23.8 0.0 4.4e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Cupin domain Cupin_1 PF00190.22 EMD66946.1 - 0.0025 17.4 0.0 0.0038 16.8 0.0 1.3 1 0 0 1 1 1 1 Cupin DZR PF12773.7 EMD66946.1 - 0.0037 17.2 4.8 0.0037 17.2 4.8 1.9 2 0 0 2 2 2 1 Double zinc ribbon ARD PF03079.14 EMD66946.1 - 0.03 14.5 0.0 0.048 13.8 0.0 1.3 1 0 0 1 1 1 0 ARD/ARD' family zf-RRN7 PF11781.8 EMD66946.1 - 0.19 11.4 6.9 4.6 7.0 1.5 2.4 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 OrfB_Zn_ribbon PF07282.11 EMD66946.1 - 7.9 6.5 6.9 4.6 7.2 0.3 2.5 1 1 1 2 2 2 0 Putative transposase DNA-binding domain Ctr PF04145.15 EMD66947.1 - 2.9e-32 112.3 5.7 5.5e-32 111.4 5.7 1.4 1 1 0 1 1 1 1 Ctr copper transporter family DUF4191 PF13829.6 EMD66947.1 - 0.67 9.3 2.4 1.2 8.5 2.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) FAD_binding_2 PF00890.24 EMD66948.1 - 7.8e-81 272.3 0.4 9.4e-81 272.0 0.4 1.1 1 0 0 1 1 1 1 FAD binding domain Cyt-b5 PF00173.28 EMD66948.1 - 4.2e-20 71.7 0.8 9e-19 67.4 0.0 3.2 5 0 0 5 5 4 1 Cytochrome b5-like Heme/Steroid binding domain DAO PF01266.24 EMD66948.1 - 8e-12 45.4 0.4 2.7e-11 43.7 0.4 1.8 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_oxidored PF12831.7 EMD66948.1 - 3e-09 36.7 0.7 1.1e-08 34.9 0.7 1.9 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EMD66948.1 - 7.9e-08 32.4 0.5 5.2e-07 29.8 0.2 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EMD66948.1 - 1.5e-07 30.9 0.2 6.5e-07 28.9 0.1 2.0 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EMD66948.1 - 1.4e-06 27.3 1.7 0.0026 16.5 0.3 3.1 3 0 0 3 3 3 2 HI0933-like protein Pyr_redox_3 PF13738.6 EMD66948.1 - 2e-06 27.3 0.1 0.021 14.1 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EMD66948.1 - 0.00018 20.8 1.2 0.031 13.5 0.3 2.3 2 0 0 2 2 2 2 Thi4 family GIDA PF01134.22 EMD66948.1 - 0.00028 20.1 1.3 0.013 14.6 0.6 2.2 2 0 0 2 2 2 1 Glucose inhibited division protein A Amino_oxidase PF01593.24 EMD66948.1 - 0.00091 18.6 0.2 1.4 8.1 0.1 3.2 3 0 0 3 3 3 1 Flavin containing amine oxidoreductase FAD_binding_3 PF01494.19 EMD66948.1 - 0.0036 16.6 1.4 0.0055 16.0 0.4 1.7 2 0 0 2 2 2 1 FAD binding domain IF2_N PF04760.15 EMD66948.1 - 0.0081 16.0 0.5 0.02 14.7 0.5 1.7 1 0 0 1 1 1 1 Translation initiation factor IF-2, N-terminal region AlaDh_PNT_C PF01262.21 EMD66948.1 - 0.019 14.2 0.3 0.034 13.4 0.3 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_9 PF13454.6 EMD66948.1 - 0.034 14.1 0.9 1 9.3 0.9 2.5 1 1 0 1 1 1 0 FAD-NAD(P)-binding Pyr_redox PF00070.27 EMD66948.1 - 0.12 13.0 1.7 4.7 7.8 0.2 2.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 EMD66948.1 - 0.12 12.2 0.1 0.21 11.5 0.1 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Metallophos PF00149.28 EMD66949.1 - 3.8e-08 34.1 4.4 8.3e-08 33.0 4.4 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase FAM199X PF15814.5 EMD66949.1 - 6.7 5.7 7.3 2.7 7.0 4.8 1.5 2 0 0 2 2 2 0 Protein family FAM199X tRNA-synt_2c PF01411.19 EMD66950.1 - 1.3e-217 723.7 0.0 2e-217 723.1 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (A) tRNA_SAD PF07973.14 EMD66950.1 - 4.5e-17 61.9 0.3 1.3e-16 60.4 0.3 1.9 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain DHHA1 PF02272.19 EMD66950.1 - 6.8e-10 39.5 0.5 6.8e-10 39.5 0.5 2.2 2 0 0 2 2 2 1 DHHA1 domain Dehydratase_SU PF02287.15 EMD66950.1 - 0.033 14.3 1.0 1.2 9.2 0.4 2.9 3 0 0 3 3 3 0 Dehydratase small subunit Mer2 PF09074.10 EMD66950.1 - 0.43 10.4 4.6 0.43 10.4 3.2 1.6 2 0 0 2 2 2 0 Mer2 NRDE-2 PF08424.10 EMD66951.1 - 0.35 9.9 1.4 0.54 9.3 1.4 1.4 1 1 0 1 1 1 0 NRDE-2, necessary for RNA interference RCR PF12273.8 EMD66952.1 - 3.4e-07 30.9 18.3 2e-06 28.4 18.3 1.9 1 1 0 1 1 1 1 Chitin synthesis regulation, resistance to Congo red zf-HC5HC2H_2 PF13832.6 EMD66953.1 - 3.9e-18 65.6 29.3 5.1e-18 65.3 2.7 4.1 3 1 0 3 3 3 2 PHD-zinc-finger like domain BAH PF01426.18 EMD66953.1 - 2.3e-16 59.8 0.2 5.5e-16 58.5 0.2 1.6 1 0 0 1 1 1 1 BAH domain zf-HC5HC2H PF13771.6 EMD66953.1 - 8.8e-12 45.1 4.1 8.8e-12 45.1 4.1 4.6 4 1 0 4 4 4 1 PHD-like zinc-binding domain PHD PF00628.29 EMD66953.1 - 4.3e-10 39.3 55.2 7.7e-07 28.9 8.5 6.0 6 0 0 6 6 6 2 PHD-finger PHD_2 PF13831.6 EMD66953.1 - 2.2e-08 33.5 4.7 2.2e-08 33.5 4.7 4.6 5 0 0 5 5 5 1 PHD-finger Helicase_C PF00271.31 EMD66955.1 - 2.7e-21 76.0 0.4 8.3e-21 74.4 0.1 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EMD66955.1 - 1.2e-20 74.2 0.0 2.5e-20 73.2 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EMD66955.1 - 6.8e-17 61.8 0.0 1.4e-16 60.8 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase SWI2_SNF2 PF18766.1 EMD66955.1 - 0.015 14.9 0.0 0.029 14.0 0.0 1.4 1 0 0 1 1 1 0 SWI2/SNF2 ATPase ERCC3_RAD25_C PF16203.5 EMD66955.1 - 0.019 14.2 0.0 0.055 12.7 0.0 1.7 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase AAA_22 PF13401.6 EMD66955.1 - 0.03 14.6 0.0 0.082 13.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain ERO1 PF04137.15 EMD66956.1 - 1.2e-134 449.1 0.0 1.4e-134 448.8 0.0 1.1 1 0 0 1 1 1 1 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) PRY PF13765.6 EMD66956.1 - 0.073 12.7 0.0 0.52 10.0 0.0 2.4 2 0 0 2 2 2 0 SPRY-associated domain G3P_acyltransf PF02660.15 EMD66958.1 - 0.12 12.4 4.6 0.13 12.3 4.6 1.1 1 0 0 1 1 1 0 Glycerol-3-phosphate acyltransferase SLATT_5 PF18160.1 EMD66958.1 - 0.38 10.0 5.0 0.52 9.6 5.0 1.2 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 5 DUF1700 PF08006.11 EMD66958.1 - 0.57 9.7 8.2 0.69 9.4 8.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1700) DUF2207 PF09972.9 EMD66958.1 - 3.8 6.1 5.6 4.2 6.0 5.6 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) ORC6 PF05460.13 EMD66959.1 - 0.012 14.9 4.2 0.016 14.5 4.2 1.1 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) HDV_ag PF01517.18 EMD66959.1 - 0.038 13.8 4.0 0.052 13.3 4.0 1.2 1 0 0 1 1 1 0 Hepatitis delta virus delta antigen F_actin_cap_B PF01115.17 EMD66960.1 - 7.9e-106 353.0 0.0 9.2e-106 352.8 0.0 1.0 1 0 0 1 1 1 1 F-actin capping protein, beta subunit RNase_PH_C PF03725.15 EMD66960.1 - 0.076 13.1 0.0 0.15 12.1 0.0 1.4 1 0 0 1 1 1 0 3' exoribonuclease family, domain 2 F-actin_cap_A PF01267.17 EMD66960.1 - 0.17 11.3 0.1 3.9 6.8 0.0 2.4 2 2 1 3 3 3 0 F-actin capping protein alpha subunit Peptidase_M10 PF00413.24 EMD66961.1 - 4.1e-16 59.2 0.1 6.9e-16 58.5 0.1 1.4 1 0 0 1 1 1 1 Matrixin Reprolysin_3 PF13582.6 EMD66961.1 - 0.0067 16.9 0.0 0.02 15.4 0.0 2.0 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Astacin PF01400.24 EMD66961.1 - 0.0068 16.0 0.0 0.011 15.3 0.0 1.3 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) Reprolysin_4 PF13583.6 EMD66961.1 - 0.008 15.8 1.5 0.19 11.3 0.4 2.7 2 1 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Metallopep PF12044.8 EMD66961.1 - 0.013 14.1 0.2 0.024 13.3 0.2 1.4 1 0 0 1 1 1 0 Putative peptidase family Peptidase_M66 PF10462.9 EMD66961.1 - 0.018 14.0 0.1 0.032 13.2 0.1 1.4 1 0 0 1 1 1 0 Peptidase M66 MPTase-PolyVal PF18818.1 EMD66961.1 - 0.043 13.9 0.0 0.077 13.0 0.0 1.3 1 0 0 1 1 1 0 Metallopeptidase superfamily domain DUF4953 PF16313.5 EMD66961.1 - 0.048 12.9 0.0 0.092 11.9 0.0 1.4 1 0 0 1 1 1 0 Met-zincin Glyco_transf_64 PF09258.10 EMD66961.1 - 0.16 11.2 0.1 0.26 10.5 0.1 1.3 1 0 0 1 1 1 0 Glycosyl transferase family 64 domain Fungal_trans PF04082.18 EMD66962.1 - 7.4e-24 84.2 3.7 1.1e-23 83.6 3.7 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD66962.1 - 1.8e-10 40.8 12.9 1.8e-10 40.8 12.9 2.0 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain adh_short_C2 PF13561.6 EMD66963.1 - 1.6e-21 77.0 0.2 2.1e-21 76.5 0.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EMD66963.1 - 2.1e-18 66.5 0.1 2.5e-18 66.3 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EMD66963.1 - 0.00037 20.5 1.0 0.00039 20.4 0.0 1.5 2 0 0 2 2 2 1 KR domain Thioredoxin PF00085.20 EMD66964.1 - 3e-31 107.5 3.4 5.8e-25 87.3 0.0 2.9 3 0 0 3 3 3 2 Thioredoxin OST3_OST6 PF04756.13 EMD66964.1 - 3.2e-08 33.3 0.1 1.5e-06 27.8 0.0 2.7 3 0 0 3 3 3 1 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 EMD66964.1 - 3.7e-06 27.4 0.6 0.039 14.4 0.1 2.9 1 1 1 2 2 2 2 Thioredoxin-like domain Thioredoxin_8 PF13905.6 EMD66964.1 - 0.0028 18.0 0.0 1.1 9.6 0.0 3.1 2 1 0 2 2 2 1 Thioredoxin-like QSOX_Trx1 PF18108.1 EMD66964.1 - 0.0085 16.3 0.0 0.032 14.4 0.0 2.0 2 0 0 2 2 2 1 QSOX Trx-like domain HTH_6 PF01418.17 EMD66964.1 - 0.021 14.8 0.0 0.38 10.7 0.0 2.6 2 0 0 2 2 2 0 Helix-turn-helix domain, rpiR family AhpC-TSA PF00578.21 EMD66964.1 - 0.022 14.6 0.0 0.2 11.6 0.0 2.4 2 0 0 2 2 2 0 AhpC/TSA family TraF PF13728.6 EMD66964.1 - 0.11 12.3 0.0 0.11 12.3 0.0 3.8 4 0 0 4 4 4 0 F plasmid transfer operon protein Thioredoxin_3 PF13192.6 EMD66964.1 - 1.8 8.6 4.2 9.5 6.3 0.1 3.0 3 0 0 3 3 3 0 Thioredoxin domain Vta1 PF04652.16 EMD66965.1 - 1.5e-47 161.2 4.2 2.2e-47 160.6 2.7 1.8 2 0 0 2 2 2 1 Vta1 like Vta1_C PF18097.1 EMD66965.1 - 2.1e-16 59.3 1.3 2.1e-16 59.3 1.3 1.8 2 0 0 2 2 2 1 Vta1 C-terminal domain ANAPC4_WD40 PF12894.7 EMD66965.1 - 0.2 11.9 0.1 0.44 10.9 0.0 1.6 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Sec1 PF00995.23 EMD66966.1 - 2.3e-111 373.8 0.0 2.6e-111 373.6 0.0 1.0 1 0 0 1 1 1 1 Sec1 family Rax2 PF12768.7 EMD66967.1 - 3.4e-68 229.3 0.6 9.9e-67 224.5 0.0 3.1 3 0 0 3 3 3 1 Cortical protein marker for cell polarity Reg_prop PF07494.11 EMD66967.1 - 0.038 14.2 1.9 1.7 9.1 0.0 4.2 5 0 0 5 5 5 0 Two component regulator propeller Kelch_2 PF07646.15 EMD66967.1 - 0.04 13.9 0.6 21 5.3 0.0 4.1 5 0 0 5 5 5 0 Kelch motif Kelch_1 PF01344.25 EMD66967.1 - 0.081 12.5 0.0 0.95 9.1 0.0 2.7 2 0 0 2 2 2 0 Kelch motif Kelch_3 PF13415.6 EMD66967.1 - 0.49 10.7 2.7 5.9 7.3 0.0 4.1 3 0 0 3 3 3 0 Galactose oxidase, central domain Smim3 PF17307.2 EMD66967.1 - 4.4 6.9 6.0 1.1 8.8 2.5 1.7 2 0 0 2 2 2 0 Small integral membrane protein 3 MFS_1 PF07690.16 EMD66968.1 - 1.3e-41 142.7 59.6 1.3e-41 142.7 59.6 1.8 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EMD66968.1 - 2.5e-18 65.9 29.7 3.5e-18 65.4 29.7 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EMD66968.1 - 9.1e-14 51.2 12.9 9.1e-14 51.2 12.9 2.9 3 0 0 3 3 3 1 Sugar (and other) transporter Glyco_hydro_18 PF00704.28 EMD66970.1 - 1.4e-72 245.1 0.0 1.6e-72 244.9 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Comm PF15957.5 EMD66970.1 - 0.14 12.5 0.0 12 6.3 0.0 2.3 2 0 0 2 2 2 0 Commissureless zf-CCCH PF00642.24 EMD66971.1 - 4.5e-18 64.7 39.1 3.1e-06 27.0 0.2 5.6 4 1 1 5 5 5 4 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EMD66971.1 - 9.9e-16 57.2 41.0 2.2e-06 27.5 1.8 5.4 5 0 0 5 5 5 4 Zinc finger domain Torus PF16131.5 EMD66971.1 - 2.5e-12 47.4 28.7 0.00031 21.4 0.5 5.4 1 1 4 5 5 5 5 Torus domain zf-CCCH_4 PF18044.1 EMD66971.1 - 1e-07 31.6 41.9 0.00012 21.8 0.5 5.6 5 1 0 5 5 5 5 CCCH-type zinc finger zf-CCCH_3 PF15663.5 EMD66971.1 - 9.3e-05 22.6 19.8 0.00031 20.9 5.8 2.7 1 1 1 2 2 2 2 Zinc-finger containing family WD40 PF00400.32 EMD66972.1 - 9.8e-17 61.0 9.1 0.0083 17.0 0.1 5.8 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD66972.1 - 7.5e-08 32.6 0.3 0.014 15.6 0.1 4.0 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EMD66972.1 - 7.4e-05 21.6 1.2 0.00057 18.7 0.2 2.5 2 1 1 3 3 3 1 Nucleoporin Nup120/160 Caskin1-CID PF16600.5 EMD66973.1 - 0.047 14.3 2.6 0.047 14.3 2.6 2.8 2 1 0 2 2 2 0 Caskin1 CASK-interaction domain Ribosomal_L37 PF08561.10 EMD66974.1 - 1.6e-43 148.1 1.2 1.6e-43 148.1 1.2 1.5 2 0 0 2 2 2 1 Mitochondrial ribosomal protein L37 DUF726 PF05277.12 EMD66975.1 - 3e-126 421.0 4.0 4.4e-126 420.4 4.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF726) Fcf1 PF04900.12 EMD66976.1 - 5.8e-31 106.8 0.3 9e-31 106.2 0.3 1.3 1 0 0 1 1 1 1 Fcf1 PIN_9 PF18477.1 EMD66976.1 - 0.0041 17.4 0.3 0.013 15.8 0.1 1.9 1 1 1 2 2 2 1 PIN like domain Abhydrolase_6 PF12697.7 EMD66977.1 - 1.8e-20 74.5 1.9 1.8e-20 74.5 1.9 1.4 2 0 0 2 2 2 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EMD66977.1 - 0.00014 21.2 0.1 0.00028 20.3 0.1 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_2 PF02230.16 EMD66977.1 - 0.021 14.7 0.0 0.78 9.5 0.0 2.1 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Abhydrolase_1 PF00561.20 EMD66977.1 - 0.031 13.9 0.6 7.4 6.1 0.0 2.5 3 0 0 3 3 3 0 alpha/beta hydrolase fold Thioesterase PF00975.20 EMD66977.1 - 0.13 12.4 0.0 0.37 10.9 0.0 1.8 2 0 0 2 2 2 0 Thioesterase domain PGAP1 PF07819.13 EMD66977.1 - 0.17 11.6 0.0 0.27 10.9 0.0 1.2 1 0 0 1 1 1 0 PGAP1-like protein PAF-AH_p_II PF03403.13 EMD66977.1 - 0.28 9.7 0.5 14 4.1 0.1 2.1 1 1 1 2 2 2 0 Platelet-activating factor acetylhydrolase, isoform II DUF2417 PF10329.9 EMD66978.1 - 4e-86 288.3 0.3 5.8e-86 287.7 0.3 1.2 1 0 0 1 1 1 1 Region of unknown function (DUF2417) PBP_sp32 PF07222.12 EMD66978.1 - 7 6.0 5.4 2.5 7.5 2.9 1.5 2 0 0 2 2 2 0 Proacrosin binding protein sp32 Pal1 PF08316.11 EMD66979.1 - 4.9e-09 37.1 0.9 1.7e-08 35.3 0.0 2.3 3 0 0 3 3 3 1 Pal1 cell morphology protein HVSL PF09749.9 EMD66980.1 - 1.3e-77 260.4 0.0 1.6e-77 260.2 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised conserved protein DUF3182 PF11379.8 EMD66981.1 - 0.049 12.6 0.0 0.062 12.3 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3182) Glyco_hydro_17 PF00332.18 EMD66982.1 - 1.7e-05 24.6 0.2 0.00066 19.4 0.3 2.4 1 1 2 3 3 3 3 Glycosyl hydrolases family 17 DUF1294 PF06961.13 EMD66983.1 - 8.8e-24 83.5 0.3 1.6e-23 82.7 0.3 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1294) DUF4199 PF13858.6 EMD66984.1 - 0.0012 19.2 0.0 0.0016 18.9 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF4199) Pkinase PF00069.25 EMD66985.1 - 1.2e-69 234.7 0.0 1.6e-69 234.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD66985.1 - 6.8e-38 130.4 0.0 9.3e-38 130.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMD66985.1 - 1.4e-06 27.9 0.0 1.9e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EMD66985.1 - 0.00079 18.3 0.0 0.0015 17.4 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EMD66985.1 - 0.00089 18.7 0.0 0.0016 17.9 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.9 EMD66985.1 - 0.0009 18.8 0.1 0.0043 16.6 0.1 2.1 2 0 0 2 2 2 1 PhoP regulatory network protein YrbL TetR_C_27 PF17935.1 EMD66985.1 - 0.032 14.3 0.0 0.085 12.9 0.0 1.7 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain Bromodomain PF00439.25 EMD66986.1 - 6.6e-36 122.2 0.4 2.6e-19 69.1 0.2 2.5 2 0 0 2 2 2 2 Bromodomain RabGAP-TBC PF00566.18 EMD66987.1 - 7e-34 117.4 0.0 8.7e-27 94.2 0.0 2.1 2 0 0 2 2 2 2 Rab-GTPase-TBC domain Cupin_8 PF13621.6 EMD66988.1 - 3.1e-13 50.0 0.0 5.1e-11 42.8 0.0 2.2 1 1 0 1 1 1 1 Cupin-like domain JmjC PF02373.22 EMD66988.1 - 4.8e-09 36.7 0.0 1.5e-08 35.0 0.0 1.8 1 1 0 1 1 1 1 JmjC domain, hydroxylase F-box-like PF12937.7 EMD66988.1 - 3.3e-07 30.1 0.2 6.4e-07 29.2 0.2 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EMD66988.1 - 1.5e-06 28.0 0.2 2.9e-06 27.0 0.2 1.5 1 0 0 1 1 1 1 F-box domain Elongin_A PF06881.11 EMD66988.1 - 0.032 14.8 0.0 0.083 13.4 0.0 1.6 1 0 0 1 1 1 0 RNA polymerase II transcription factor SIII (Elongin) subunit A Helicase_C PF00271.31 EMD66989.1 - 3.5e-32 111.0 0.4 6.4e-31 107.0 0.1 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 EMD66989.1 - 3.7e-16 59.4 2.5 3.7e-15 56.1 1.5 2.4 1 1 1 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 EMD66989.1 - 0.00028 20.9 0.1 0.00045 20.2 0.1 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 EMD66989.1 - 0.00069 19.4 0.1 0.0011 18.7 0.1 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EMD66989.1 - 0.0025 18.2 2.1 0.0097 16.2 2.0 2.0 1 1 0 1 1 1 1 AAA domain fragilysinNterm PF16376.5 EMD66989.1 - 0.077 12.7 0.0 0.25 11.1 0.0 1.8 1 0 0 1 1 1 0 N-terminal domain of fragilysin NUDIX PF00293.28 EMD66990.1 - 5.7e-11 42.6 0.0 1.6e-10 41.1 0.0 1.8 1 1 0 1 1 1 1 NUDIX domain SLAC1 PF03595.17 EMD66991.1 - 1.3e-77 261.3 37.6 1.5e-77 261.1 37.6 1.0 1 0 0 1 1 1 1 Voltage-dependent anion channel APH PF01636.23 EMD66993.1 - 9.9e-35 120.6 0.0 1.3e-34 120.2 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase PF00069.25 EMD66993.1 - 0.0007 19.0 0.0 0.9 8.8 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain EcKinase PF02958.20 EMD66993.1 - 0.001 18.4 0.0 0.0017 17.7 0.0 1.3 1 0 0 1 1 1 1 Ecdysteroid kinase Choline_kinase PF01633.20 EMD66993.1 - 0.1 12.2 0.0 0.16 11.5 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase Kinesin PF00225.23 EMD66994.1 - 1.7e-113 378.9 0.0 2.9e-113 378.2 0.0 1.4 1 0 0 1 1 1 1 Kinesin motor domain DUF3694 PF12473.8 EMD66994.1 - 4.7e-38 131.2 0.0 1.4e-37 129.7 0.0 1.9 1 0 0 1 1 1 1 Kinesin protein Kinesin_assoc PF16183.5 EMD66994.1 - 6.3e-37 127.5 15.2 5.8e-31 108.0 0.7 3.8 3 1 0 4 4 4 2 Kinesin-associated Microtub_bd PF16796.5 EMD66994.1 - 1.4e-23 83.5 0.0 4.7e-23 81.8 0.0 1.9 1 0 0 1 1 1 1 Microtubule binding PH PF00169.29 EMD66994.1 - 4.6e-05 23.9 0.0 0.00019 21.9 0.0 2.1 2 0 0 2 2 2 1 PH domain KIF1B PF12423.8 EMD66994.1 - 0.008 16.6 1.3 0.008 16.6 1.3 2.4 2 0 0 2 2 2 1 Kinesin protein 1B PH_11 PF15413.6 EMD66994.1 - 0.084 13.3 0.0 0.26 11.7 0.0 1.9 1 0 0 1 1 1 0 Pleckstrin homology domain Plk4_PB2 PF18409.1 EMD66994.1 - 5.8 7.6 5.2 14 6.4 0.2 3.1 2 1 0 2 2 2 0 Polo-like Kinase 4 Polo Box 2 Met_10 PF02475.16 EMD66995.1 - 1.6e-67 227.2 0.0 2.2e-67 226.7 0.0 1.3 1 0 0 1 1 1 1 Met-10+ like-protein TRM PF02005.16 EMD66995.1 - 0.00073 18.8 0.0 0.0015 17.8 0.0 1.5 2 0 0 2 2 2 1 N2,N2-dimethylguanosine tRNA methyltransferase HATPase_c_3 PF13589.6 EMD66996.1 - 1.9e-11 44.0 0.0 3.8e-11 42.9 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 EMD66996.1 - 1.9e-07 31.6 0.0 5.5e-07 30.1 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DNA_mis_repair PF01119.19 EMD66996.1 - 0.0077 15.9 0.0 0.16 11.7 0.0 2.3 2 0 0 2 2 2 1 DNA mismatch repair protein, C-terminal domain Ada_Zn_binding PF02805.16 EMD66997.1 - 1.7e-28 98.4 4.9 1.7e-28 98.4 4.9 2.0 2 1 0 2 2 2 1 Metal binding domain of Ada PA_decarbox PF05870.11 EMD67000.1 - 3.1e-10 39.9 0.4 3.5e-10 39.7 0.4 1.1 1 0 0 1 1 1 1 Phenolic acid decarboxylase (PAD) Transp_cyt_pur PF02133.15 EMD67001.1 - 2e-94 316.9 32.4 2.3e-94 316.7 32.4 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin DUF2393 PF09624.10 EMD67001.1 - 0.2 11.6 1.6 0.42 10.6 0.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2393) DUF917 PF06032.12 EMD67002.1 - 2.3e-125 418.1 0.8 5.6e-125 416.8 0.8 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF917) Hydantoinase_A PF01968.18 EMD67002.1 - 3.5e-30 105.2 9.2 7.1e-27 94.4 0.5 4.0 4 0 0 4 4 4 2 Hydantoinase/oxoprolinase Hydant_A_N PF05378.13 EMD67002.1 - 1e-29 103.5 1.3 4.2e-27 95.0 0.4 3.0 2 1 0 2 2 2 2 Hydantoinase/oxoprolinase N-terminal region MutL PF13941.6 EMD67002.1 - 1.4e-05 23.9 1.6 0.0028 16.3 0.0 2.3 2 0 0 2 2 2 2 MutL protein ROK PF00480.20 EMD67002.1 - 0.00061 19.4 0.3 0.0029 17.1 0.1 2.3 2 0 0 2 2 2 1 ROK family BcrAD_BadFG PF01869.20 EMD67002.1 - 0.0022 17.5 8.3 0.0027 17.3 0.2 3.2 3 1 0 3 3 3 1 BadF/BadG/BcrA/BcrD ATPase family StbA PF06406.11 EMD67002.1 - 0.0026 17.0 0.1 2.1 7.5 0.0 2.5 2 0 0 2 2 2 2 StbA protein DUF3751 PF12571.8 EMD67002.1 - 0.014 15.5 0.0 0.05 13.7 0.0 1.9 1 0 0 1 1 1 0 Phage tail-collar fibre protein Mito_carr PF00153.27 EMD67003.1 - 6.5e-60 199.1 2.3 1.2e-20 73.2 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein P5CR_dimer PF14748.6 EMD67003.1 - 0.033 14.4 0.1 0.083 13.2 0.1 1.7 1 0 0 1 1 1 0 Pyrroline-5-carboxylate reductase dimerisation DUF3042 PF11240.8 EMD67003.1 - 0.094 12.7 0.5 18 5.4 0.0 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3042) Pyr_redox_2 PF07992.14 EMD67004.1 - 1.9e-14 53.6 0.0 3.8e-08 32.9 0.0 2.4 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EMD67004.1 - 1.2e-09 37.9 0.0 0.013 14.8 0.0 3.7 3 1 0 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EMD67004.1 - 2.5e-08 33.5 0.0 0.002 17.4 0.0 2.5 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.24 EMD67004.1 - 1.6e-05 24.7 0.3 0.54 9.8 0.0 3.9 4 1 0 4 4 4 2 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 EMD67004.1 - 9.2e-05 21.8 0.0 0.0034 16.7 0.0 2.3 2 0 0 2 2 2 1 FAD binding domain NAD_binding_8 PF13450.6 EMD67004.1 - 9.7e-05 22.5 0.1 0.003 17.8 0.0 2.5 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain ApbA PF02558.16 EMD67004.1 - 0.00027 20.6 0.0 0.0045 16.6 0.0 2.6 2 1 1 3 3 3 1 Ketopantoate reductase PanE/ApbA HI0933_like PF03486.14 EMD67004.1 - 0.00043 19.1 0.0 0.0012 17.6 0.0 1.7 2 0 0 2 2 2 1 HI0933-like protein Lycopene_cycl PF05834.12 EMD67004.1 - 0.00086 18.5 0.1 0.02 14.0 0.0 2.1 2 0 0 2 2 2 1 Lycopene cyclase protein FAD_binding_2 PF00890.24 EMD67004.1 - 0.00092 18.4 0.0 0.002 17.3 0.0 1.6 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.27 EMD67004.1 - 0.0017 18.9 0.0 4.8 7.8 0.0 3.4 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 EMD67004.1 - 0.0063 15.8 0.0 0.13 11.6 0.0 2.3 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain Thi4 PF01946.17 EMD67004.1 - 0.026 13.7 0.0 0.042 13.1 0.0 1.3 1 0 0 1 1 1 0 Thi4 family NAD_binding_9 PF13454.6 EMD67004.1 - 0.036 14.1 1.5 0.44 10.5 0.2 3.3 4 1 0 4 4 4 0 FAD-NAD(P)-binding Glyco_transf_34 PF05637.12 EMD67006.1 - 2.8e-16 60.0 0.7 5.9e-16 58.9 0.7 1.5 1 1 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family Nucleotid_trans PF03407.16 EMD67006.1 - 0.00071 19.6 0.0 0.0012 18.9 0.0 1.3 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase Hce2 PF14856.6 EMD67007.1 - 9.1e-26 90.1 0.4 1.1e-25 89.8 0.4 1.1 1 0 0 1 1 1 1 Pathogen effector; putative necrosis-inducing factor HDPD PF02924.14 EMD67008.1 - 0.11 12.6 2.4 0.14 12.3 1.3 1.7 2 1 0 2 2 2 0 Bacteriophage lambda head decoration protein D zf-RING_11 PF17123.5 EMD67010.1 - 0.059 13.1 0.1 0.11 12.2 0.1 1.5 1 0 0 1 1 1 0 RING-like zinc finger TMEM192 PF14802.6 EMD67011.1 - 0.038 13.1 0.3 0.048 12.7 0.3 1.2 1 0 0 1 1 1 0 TMEM192 family DUF373 PF04123.13 EMD67011.1 - 0.2 11.1 3.0 0.25 10.8 3.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF373) Vma12 PF11712.8 EMD67011.1 - 0.29 11.2 2.3 0.56 10.3 2.3 1.5 1 0 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase DUF4199 PF13858.6 EMD67011.1 - 3.2 8.1 6.9 4.4 7.7 6.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) UPF0242 PF06785.11 EMD67011.1 - 5.1 7.1 4.0 7.1 6.7 4.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF676 PF05057.14 EMD67015.1 - 1.1e-06 28.3 0.0 1.6e-06 27.8 0.0 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) PGAP1 PF07819.13 EMD67015.1 - 2.1e-05 24.4 0.0 4.4e-05 23.3 0.0 1.6 1 1 0 1 1 1 1 PGAP1-like protein Abhydrolase_6 PF12697.7 EMD67015.1 - 7.7e-05 23.4 0.0 9.5e-05 23.1 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_8 PF06259.12 EMD67015.1 - 0.017 14.8 0.0 0.026 14.2 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase Hydrolase_4 PF12146.8 EMD67015.1 - 0.042 13.1 0.0 0.063 12.5 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EMD67015.1 - 0.043 13.4 0.0 0.074 12.7 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Lipase_3 PF01764.25 EMD67015.1 - 0.083 12.7 0.0 0.12 12.2 0.0 1.2 1 0 0 1 1 1 0 Lipase (class 3) Ank_2 PF12796.7 EMD67017.1 - 2.1e-06 28.2 1.8 0.0099 16.5 0.3 2.7 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMD67017.1 - 0.018 15.6 0.2 1.9 9.2 0.0 2.7 2 1 0 2 2 2 0 Ankyrin repeats (many copies) HET PF06985.11 EMD67020.1 - 2.6e-10 40.8 0.2 3.6e-10 40.4 0.2 1.3 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) AAA_16 PF13191.6 EMD67021.1 - 9.9e-06 26.0 0.0 1.2e-05 25.8 0.0 1.1 1 0 0 1 1 1 1 AAA ATPase domain NACHT PF05729.12 EMD67021.1 - 3.9e-05 23.6 0.0 4.6e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 NACHT domain DUF2075 PF09848.9 EMD67021.1 - 0.00055 19.3 0.0 0.00057 19.2 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) RNA_helicase PF00910.22 EMD67021.1 - 0.0018 18.6 0.0 0.0027 18.1 0.0 1.3 1 0 0 1 1 1 1 RNA helicase GvpD PF07088.11 EMD67021.1 - 0.0081 14.8 0.0 0.0094 14.6 0.0 1.1 1 0 0 1 1 1 1 GvpD gas vesicle protein AAA_22 PF13401.6 EMD67021.1 - 0.0088 16.3 0.0 0.011 16.0 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 EMD67021.1 - 0.012 16.1 0.0 0.013 15.9 0.0 1.2 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.12 EMD67021.1 - 0.013 14.8 0.1 0.029 13.7 0.0 1.5 2 0 0 2 2 2 0 Zeta toxin Sigma54_activat PF00158.26 EMD67021.1 - 0.016 14.9 0.0 0.022 14.5 0.0 1.2 1 0 0 1 1 1 0 Sigma-54 interaction domain TrwB_AAD_bind PF10412.9 EMD67021.1 - 0.017 14.1 0.0 0.022 13.7 0.0 1.2 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain AAA_28 PF13521.6 EMD67021.1 - 0.022 15.0 0.0 0.027 14.7 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 EMD67021.1 - 0.024 15.0 0.0 0.03 14.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain ResIII PF04851.15 EMD67021.1 - 0.033 14.2 0.0 0.033 14.2 0.0 1.2 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit NB-ARC PF00931.22 EMD67021.1 - 0.034 13.3 0.0 0.034 13.3 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain cobW PF02492.19 EMD67021.1 - 0.064 12.8 0.0 0.084 12.5 0.0 1.2 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_30 PF13604.6 EMD67021.1 - 0.099 12.3 0.0 0.1 12.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EMD67021.1 - 0.1 13.1 0.0 0.11 13.0 0.0 1.2 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 EMD67021.1 - 0.17 11.2 0.0 0.29 10.5 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI CpeT PF06206.11 EMD67021.1 - 0.18 11.7 0.0 0.23 11.4 0.0 1.1 1 0 0 1 1 1 0 CpeT/CpcT family (DUF1001) Lactamase_B PF00753.27 EMD67023.1 - 6.6e-09 36.1 1.2 2.7e-08 34.0 1.2 2.0 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EMD67023.1 - 9.7e-07 28.5 0.1 2.9e-05 23.7 0.1 2.3 2 0 0 2 2 2 2 Beta-lactamase superfamily domain HTH_Tnp_Tc5 PF03221.16 EMD67024.1 - 1.1e-07 31.8 0.6 3.9e-07 30.0 0.6 1.9 1 1 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EMD67024.1 - 2.3e-07 30.5 0.0 3.9e-07 29.7 0.0 1.4 1 0 0 1 1 1 1 helix-turn-helix, Psq domain HTH_23 PF13384.6 EMD67024.1 - 0.0063 16.3 0.4 0.025 14.4 0.0 2.0 2 0 0 2 2 2 1 Homeodomain-like domain HTH_28 PF13518.6 EMD67024.1 - 0.0081 16.3 0.8 0.016 15.3 0.1 1.9 2 0 0 2 2 2 1 Helix-turn-helix domain NUMOD1 PF07453.13 EMD67024.1 - 0.016 15.4 0.2 0.036 14.3 0.0 1.7 2 0 0 2 2 2 0 NUMOD1 domain TnsD PF15978.5 EMD67024.1 - 0.03 13.3 0.5 0.061 12.3 0.1 1.6 1 1 1 2 2 2 0 Tn7-like transposition protein D PNP_UDP_1 PF01048.20 EMD67025.1 - 8.4e-11 41.6 0.3 1.3e-10 40.9 0.3 1.3 1 0 0 1 1 1 1 Phosphorylase superfamily CKAP2_C PF15297.6 EMD67026.1 - 0.42 9.6 5.2 0.5 9.4 5.2 1.1 1 0 0 1 1 1 0 Cytoskeleton-associated protein 2 C-terminus HTH_Tnp_Tc5 PF03221.16 EMD67027.1 - 8.7e-08 32.1 0.0 1.7e-07 31.2 0.0 1.5 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EMD67027.1 - 0.00067 19.3 0.1 0.001 18.8 0.1 1.3 1 0 0 1 1 1 1 helix-turn-helix, Psq domain TnsD PF15978.5 EMD67027.1 - 0.012 14.6 0.1 0.015 14.3 0.1 1.1 1 0 0 1 1 1 0 Tn7-like transposition protein D Ribosomal_S13_N PF08069.12 EMD67027.1 - 0.013 15.5 0.0 0.021 14.8 0.0 1.3 1 0 0 1 1 1 0 Ribosomal S13/S15 N-terminal domain Cdc6_C PF09079.11 EMD67027.1 - 0.023 14.7 0.0 4.2 7.4 0.0 2.2 2 0 0 2 2 2 0 CDC6, C terminal winged helix domain HTH_24 PF13412.6 EMD67027.1 - 0.029 13.9 0.1 0.33 10.5 0.0 2.2 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding DUF2721 PF11026.8 EMD67027.1 - 0.2 11.5 1.0 0.28 11.1 1.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2721) HET PF06985.11 EMD67028.1 - 0.0006 20.2 0.0 0.0012 19.2 0.0 1.5 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) HYLS1_C PF15311.6 EMD67029.1 - 0.041 14.6 0.0 0.044 14.5 0.0 1.0 1 0 0 1 1 1 0 Hydrolethalus syndrome protein 1 C-terminus Arylsulfotran_2 PF14269.6 EMD67030.1 - 7.6e-76 255.3 1.7 1.1e-75 254.8 1.7 1.2 1 0 0 1 1 1 1 Arylsulfotransferase (ASST) Arylsulfotrans PF05935.11 EMD67030.1 - 0.0044 16.0 3.2 0.015 14.2 3.2 2.0 1 1 0 1 1 1 1 Arylsulfotransferase (ASST) Sulfatase PF00884.23 EMD67031.1 - 6.1e-48 163.8 0.1 3e-46 158.2 0.1 2.1 1 1 0 1 1 1 1 Sulfatase DUF4976 PF16347.5 EMD67031.1 - 0.0011 19.2 0.0 0.002 18.3 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4976) UCH PF00443.29 EMD67032.1 - 9e-10 38.5 0.1 9e-08 31.9 0.1 2.1 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EMD67032.1 - 4.8e-05 23.1 0.3 4.8e-05 23.1 0.3 1.7 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Med27 PF11571.8 EMD67032.1 - 0.0022 18.3 1.6 0.013 15.9 0.1 2.5 2 0 0 2 2 2 1 Mediator complex subunit 27 Peptidase_C98 PF15499.6 EMD67032.1 - 0.5 9.8 4.2 0.17 11.3 0.4 2.3 3 1 0 3 3 3 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase ADH_zinc_N PF00107.26 EMD67033.1 - 3.2e-21 75.6 0.1 5.9e-21 74.8 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EMD67033.1 - 8.9e-17 61.0 0.3 1.4e-16 60.3 0.3 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 EMD67033.1 - 8.5e-07 30.1 0.0 1.5e-06 29.3 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase GTPase_binding PF09027.10 EMD67033.1 - 0.036 14.1 0.3 1.7 8.7 0.1 2.4 2 0 0 2 2 2 0 GTPase binding AlaDh_PNT_C PF01262.21 EMD67033.1 - 0.12 11.7 0.1 0.19 11.0 0.1 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_2 PF03446.15 EMD67034.1 - 1.2e-38 132.8 0.1 1.9e-38 132.2 0.1 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 EMD67034.1 - 4.4e-19 68.9 0.0 6.3e-19 68.4 0.0 1.2 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase F420_oxidored PF03807.17 EMD67034.1 - 2.8e-06 27.8 0.1 8.1e-06 26.3 0.0 1.8 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.20 EMD67034.1 - 0.049 13.7 0.0 0.08 13.0 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase TrkA_N PF02254.18 EMD67034.1 - 0.093 13.0 0.0 0.2 12.0 0.0 1.6 1 0 0 1 1 1 0 TrkA-N domain Sacchrp_dh_NADP PF03435.18 EMD67034.1 - 0.098 12.9 0.0 0.18 12.1 0.0 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain CMD PF02627.20 EMD67035.1 - 1.4e-09 37.9 0.1 4.6e-07 29.8 0.1 2.3 1 1 0 1 1 1 1 Carboxymuconolactone decarboxylase family Aldedh PF00171.22 EMD67036.1 - 6.8e-149 496.3 0.0 7.9e-149 496.1 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 EMD67036.1 - 0.0071 15.8 0.0 1.2 8.6 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF1487) Abhydrolase_6 PF12697.7 EMD67037.1 - 3.6e-12 47.4 1.4 6e-12 46.6 1.4 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EMD67037.1 - 2e-10 40.8 0.1 6.8e-07 29.2 0.1 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EMD67037.1 - 0.0023 17.2 0.0 0.0098 15.2 0.0 2.1 1 1 1 2 2 2 1 Serine aminopeptidase, S33 Ribonuc_L-PSP PF01042.21 EMD67038.1 - 3.9e-14 52.7 0.0 6.2e-14 52.1 0.0 1.3 1 1 0 1 1 1 1 Endoribonuclease L-PSP Sugar_tr PF00083.24 EMD67039.1 - 1.7e-74 251.4 26.5 1.9e-74 251.2 26.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD67039.1 - 4.1e-17 62.1 46.1 8.8e-09 34.7 18.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Fungal_trans PF04082.18 EMD67040.1 - 5e-11 42.1 3.8 7.3e-11 41.6 3.8 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 EMD67040.1 - 5.7e-07 29.6 11.1 0.0024 18.3 3.5 3.2 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMD67040.1 - 0.00016 22.0 2.6 0.00016 22.0 2.6 3.6 5 0 0 5 5 5 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMD67040.1 - 0.034 15.0 2.5 0.034 15.0 2.5 3.8 4 0 0 4 4 4 0 C2H2-type zinc finger zf-UBR PF02207.20 EMD67040.1 - 0.053 13.7 1.0 0.14 12.3 1.0 1.6 1 0 0 1 1 1 0 Putative zinc finger in N-recognin (UBR box) zf-C2HC_2 PF13913.6 EMD67040.1 - 0.22 11.5 1.9 0.75 9.8 1.9 1.9 1 0 0 1 1 1 0 zinc-finger of a C2HC-type Arginase PF00491.21 EMD67041.1 - 7.6e-20 71.5 0.0 9.8e-20 71.2 0.0 1.0 1 0 0 1 1 1 1 Arginase family P2 PF07194.11 EMD67041.1 - 0.057 13.5 0.0 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 P2 response regulator binding domain Fungal_trans PF04082.18 EMD67042.1 - 2.4e-19 69.4 0.0 3.8e-19 68.7 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD67042.1 - 7e-05 22.9 9.6 0.00013 22.0 9.6 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Sugar_tr PF00083.24 EMD67044.1 - 8.9e-17 61.1 1.0 9.4e-17 61.0 1.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD67044.1 - 5.3e-05 22.3 2.9 6.5e-05 22.0 2.9 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF5391 PF17369.2 EMD67044.1 - 4.2 7.4 7.0 6.2 6.9 0.8 2.4 1 1 1 2 2 2 0 Family of unknown function (DUF5391) CN_hydrolase PF00795.22 EMD67045.1 - 2.1e-41 142.0 0.0 2.7e-41 141.7 0.0 1.1 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Beta-lactamase PF00144.24 EMD67046.1 - 4.1e-37 128.2 0.0 5.3e-37 127.8 0.0 1.1 1 0 0 1 1 1 1 Beta-lactamase NPP1 PF05630.11 EMD67047.1 - 2.3e-65 220.4 0.0 2.7e-65 220.2 0.0 1.0 1 0 0 1 1 1 1 Necrosis inducing protein (NPP1) RVT_1 PF00078.27 EMD67050.1 - 2e-05 24.2 0.1 2e-05 24.2 0.1 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DDDD PF10161.9 EMD67050.1 - 0.031 14.0 0.0 0.034 13.9 0.0 1.1 1 0 0 1 1 1 0 Putative mitochondrial precursor protein Aldo_ket_red PF00248.21 EMD67051.1 - 1.6e-40 139.1 0.1 4.1e-33 114.8 0.0 2.0 1 1 1 2 2 2 2 Aldo/keto reductase family HET PF06985.11 EMD67052.1 - 0.0049 17.2 0.0 0.053 13.9 0.0 2.3 1 1 1 2 2 2 1 Heterokaryon incompatibility protein (HET) Zn_Tnp_IS1 PF03811.13 EMD67052.1 - 0.55 10.0 2.9 0.31 10.8 0.3 1.9 2 0 0 2 2 2 0 InsA N-terminal domain PhyH PF05721.13 EMD67053.1 - 2.9e-13 50.6 0.1 4.1e-13 50.1 0.1 1.2 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) p450 PF00067.22 EMD67055.1 - 2.5e-60 204.6 0.0 3e-60 204.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Methyltransf_23 PF13489.6 EMD67056.1 - 5.3e-17 62.1 0.0 7.8e-17 61.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMD67056.1 - 1.7e-13 51.0 0.0 3.8e-13 49.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMD67056.1 - 7.9e-11 42.5 0.0 1.5e-10 41.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMD67056.1 - 2.6e-09 37.0 0.0 4.2e-08 33.1 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMD67056.1 - 3e-09 37.5 0.0 1.3e-08 35.4 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_16 PF10294.9 EMD67056.1 - 0.00075 19.3 0.0 0.0013 18.6 0.0 1.3 1 0 0 1 1 1 1 Lysine methyltransferase UPF0146 PF03686.13 EMD67056.1 - 0.0034 17.2 0.0 1.2 9.1 0.0 2.2 2 0 0 2 2 2 2 Uncharacterised protein family (UPF0146) PrmA PF06325.13 EMD67056.1 - 0.01 15.3 0.0 0.014 14.8 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Ubie_methyltran PF01209.18 EMD67056.1 - 0.015 14.7 0.0 0.19 11.0 0.0 2.1 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family MTS PF05175.14 EMD67056.1 - 0.029 13.9 0.0 0.074 12.6 0.0 1.6 2 0 0 2 2 2 0 Methyltransferase small domain DUF938 PF06080.12 EMD67056.1 - 0.033 14.0 0.0 0.069 12.9 0.0 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF938) Methyltransf_4 PF02390.17 EMD67056.1 - 0.05 13.1 0.0 0.15 11.5 0.0 1.7 2 0 0 2 2 2 0 Putative methyltransferase FtsJ PF01728.19 EMD67056.1 - 0.069 13.3 0.0 0.12 12.5 0.0 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase SSXRD PF09514.10 EMD67056.1 - 0.22 11.1 3.4 0.26 10.9 0.1 2.3 2 0 0 2 2 2 0 SSXRD motif GTP_cyclohydroI PF01227.22 EMD67057.1 - 2.4e-73 245.4 0.1 3.4e-73 244.9 0.1 1.2 1 0 0 1 1 1 1 GTP cyclohydrolase I QueF PF14489.6 EMD67057.1 - 0.0024 18.0 0.0 0.0049 17.0 0.0 1.5 1 0 0 1 1 1 1 QueF-like protein HATPase_c_2 PF13581.6 EMD67057.1 - 0.034 14.1 0.2 0.085 12.8 0.2 1.6 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain Pkinase PF00069.25 EMD67058.1 - 8.5e-71 238.4 0.0 1.3e-70 237.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD67058.1 - 3.5e-35 121.6 0.0 5.5e-35 120.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMD67058.1 - 0.0021 17.5 0.0 0.0038 16.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EMD67058.1 - 0.006 15.6 0.0 0.017 14.1 0.0 1.6 2 0 0 2 2 2 1 Haspin like kinase domain Kdo PF06293.14 EMD67058.1 - 0.0067 15.8 0.0 0.016 14.5 0.0 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EMD67058.1 - 0.13 11.0 0.0 0.13 11.0 0.0 2.8 3 0 0 3 3 3 0 Fungal protein kinase ATP-synt_B PF00430.18 EMD67058.1 - 1.1 9.3 8.8 2.6 8.1 8.8 1.5 1 0 0 1 1 1 0 ATP synthase B/B' CF(0) Peptidase_M14 PF00246.24 EMD67059.1 - 1.1e-15 58.3 0.0 2.3e-14 53.9 0.0 2.2 1 1 0 1 1 1 1 Zinc carboxypeptidase DUF2817 PF10994.8 EMD67059.1 - 0.086 12.2 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2817) BNR_4 PF15892.5 EMD67060.1 - 1.4e-71 241.1 1.7 1.8e-71 240.7 1.7 1.1 1 0 0 1 1 1 1 BNR repeat-containing family member BNR_2 PF13088.6 EMD67060.1 - 0.049 12.9 0.1 0.087 12.1 0.1 1.5 1 1 0 1 1 1 0 BNR repeat-like domain Glyco_hydr_30_2 PF14587.6 EMD67061.1 - 4.9e-20 72.5 7.5 4.9e-20 72.5 7.5 1.5 2 0 0 2 2 2 1 O-Glycosyl hydrolase family 30 DASH_Ask1 PF08655.10 EMD67061.1 - 0.14 12.0 0.0 0.36 10.7 0.0 1.6 1 0 0 1 1 1 0 DASH complex subunit Ask1 Rieske PF00355.26 EMD67062.1 - 2.4e-08 33.8 0.0 4.7e-08 32.9 0.0 1.5 1 1 0 1 1 1 1 Rieske [2Fe-2S] domain Rieske_2 PF13806.6 EMD67062.1 - 4.9e-06 26.4 0.0 8e-06 25.7 0.0 1.3 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain Peptidase_S9 PF00326.21 EMD67064.1 - 0.00063 19.3 0.2 0.0036 16.8 0.1 2.0 1 1 1 2 2 2 1 Prolyl oligopeptidase family AXE1 PF05448.12 EMD67064.1 - 0.03 13.0 0.1 0.088 11.5 0.0 1.6 2 0 0 2 2 2 0 Acetyl xylan esterase (AXE1) Esterase_phd PF10503.9 EMD67064.1 - 0.031 13.8 0.1 0.087 12.3 0.0 1.7 2 0 0 2 2 2 0 Esterase PHB depolymerase Abhydrolase_2 PF02230.16 EMD67064.1 - 0.19 11.5 0.0 0.37 10.5 0.0 1.4 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase APG6_N PF17675.1 EMD67066.1 - 0.0016 19.0 40.3 0.024 15.2 9.9 3.2 1 1 2 3 3 3 2 Apg6 coiled-coil region KASH_CCD PF14662.6 EMD67066.1 - 0.0081 16.0 31.1 0.043 13.6 13.4 2.8 1 1 2 3 3 3 2 Coiled-coil region of CCDC155 or KASH IFT57 PF10498.9 EMD67066.1 - 0.062 12.3 24.6 0.0074 15.3 10.9 2.2 1 1 0 2 2 2 0 Intra-flagellar transport protein 57 GAS PF13851.6 EMD67066.1 - 0.1 12.0 33.0 0.08 12.3 10.5 3.6 1 1 2 4 4 4 0 Growth-arrest specific micro-tubule binding Spc7 PF08317.11 EMD67066.1 - 0.64 8.8 32.8 0.1 11.5 10.0 2.6 1 1 1 2 2 2 0 Spc7 kinetochore protein ERM PF00769.19 EMD67066.1 - 0.85 9.4 40.1 0.73 9.6 16.9 2.4 1 1 1 2 2 2 0 Ezrin/radixin/moesin family ATG16 PF08614.11 EMD67066.1 - 0.91 9.7 38.4 0.33 11.1 18.8 3.1 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) DUF948 PF06103.11 EMD67066.1 - 1.1 9.6 8.8 11 6.3 0.1 3.7 2 1 2 4 4 4 0 Bacterial protein of unknown function (DUF948) YabA PF06156.13 EMD67066.1 - 1.4 9.6 26.0 1.1 9.9 2.8 3.9 1 1 3 4 4 4 0 Initiation control protein YabA HALZ PF02183.18 EMD67066.1 - 1.4 9.2 0.0 1.4 9.2 0.0 4.6 5 0 0 5 5 4 0 Homeobox associated leucine zipper Cauli_AT PF03233.13 EMD67066.1 - 1.9 8.4 13.4 0.67 9.9 3.0 2.9 2 1 1 3 3 3 0 Aphid transmission protein ZapB PF06005.12 EMD67066.1 - 2.2 8.8 29.8 2.5 8.6 2.0 4.6 2 2 2 4 4 4 0 Cell division protein ZapB DivIVA PF05103.13 EMD67066.1 - 2.7 8.1 21.6 4 7.5 9.2 3.2 2 1 0 3 3 3 0 DivIVA protein DUF2524 PF10732.9 EMD67066.1 - 2.8 8.3 12.3 0.4 11.0 1.6 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2524) DUF3450 PF11932.8 EMD67066.1 - 4.2 6.6 22.5 0.099 11.9 2.1 3.5 1 1 3 4 4 4 0 Protein of unknown function (DUF3450) DUF1664 PF07889.12 EMD67066.1 - 7.2 6.7 16.6 2.2 8.3 0.7 3.8 1 1 2 4 4 4 0 Protein of unknown function (DUF1664) TFIIA PF03153.13 EMD67067.1 - 0.88 9.5 26.7 1.5 8.7 26.7 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Methyltransf_2 PF00891.18 EMD67068.1 - 1.7e-20 73.3 0.0 2.2e-20 72.8 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain LSM PF01423.22 EMD67070.1 - 3.2e-08 33.1 0.0 4.3e-08 32.7 0.0 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EMD67070.1 - 2.8e-05 24.2 0.0 3.5e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 Ataxin 2 SM domain TMEM213 PF15192.6 EMD67070.1 - 0.015 15.3 0.0 0.02 14.8 0.0 1.3 1 0 0 1 1 1 0 TMEM213 family DUF4242 PF14026.6 EMD67070.1 - 0.084 13.1 0.2 0.15 12.2 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4242) LSM14 PF12701.7 EMD67070.1 - 0.098 12.8 0.0 0.14 12.3 0.0 1.3 1 0 0 1 1 1 0 Scd6-like Sm domain WD40 PF00400.32 EMD67073.1 - 3.3e-47 157.5 26.8 2.2e-09 37.8 0.1 12.6 13 0 0 13 13 13 9 WD domain, G-beta repeat Utp12 PF04003.12 EMD67073.1 - 2e-26 92.4 0.1 2.9e-26 91.8 0.1 1.3 1 0 0 1 1 1 1 Dip2/Utp12 Family ANAPC4_WD40 PF12894.7 EMD67073.1 - 2.4e-23 82.2 0.0 0.005 17.1 0.0 10.3 5 2 6 11 11 11 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EMD67073.1 - 2.9e-10 39.6 1.7 0.18 10.7 0.0 6.4 5 2 2 7 7 7 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 EMD67073.1 - 1.2e-06 27.5 4.8 0.48 9.0 0.0 4.5 3 2 2 5 5 5 4 Nucleoporin Nup120/160 eIF2A PF08662.11 EMD67073.1 - 1.3e-06 28.5 0.2 0.0035 17.3 0.1 5.0 6 2 1 7 7 7 1 Eukaryotic translation initiation factor eIF2A Nbas_N PF15492.6 EMD67073.1 - 0.00013 21.4 0.4 2.4 7.4 0.1 4.2 3 1 1 4 4 4 1 Neuroblastoma-amplified sequence, N terminal WD40_like PF17005.5 EMD67073.1 - 0.00021 20.8 0.0 0.32 10.3 0.0 3.8 4 0 0 4 4 4 1 WD40-like domain PALB2_WD40 PF16756.5 EMD67073.1 - 0.11 11.4 0.0 5.2 5.9 0.0 2.7 3 0 0 3 3 3 0 Partner and localizer of BRCA2 WD40 domain PD40 PF07676.12 EMD67073.1 - 0.33 10.9 2.3 3.7 7.6 0.0 4.0 6 0 0 6 6 6 0 WD40-like Beta Propeller Repeat Gmad1 PF10647.9 EMD67073.1 - 0.75 9.5 7.0 1.6 8.4 0.1 4.0 3 2 0 3 3 3 0 Lipoprotein LpqB beta-propeller domain Septin PF00735.18 EMD67074.1 - 1.1e-112 375.9 0.3 1.5e-112 375.5 0.3 1.1 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 EMD67074.1 - 2.3e-07 30.9 0.0 4.9e-07 29.8 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EMD67074.1 - 5.1e-06 26.5 0.1 2.4e-05 24.3 0.0 2.1 2 0 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 EMD67074.1 - 1.7e-05 24.5 3.6 9.2e-05 22.1 0.5 2.5 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA_22 PF13401.6 EMD67074.1 - 0.00079 19.7 0.2 0.0024 18.1 0.0 2.0 2 1 0 2 2 2 1 AAA domain Pox_A32 PF04665.12 EMD67074.1 - 0.0031 17.0 0.1 0.0051 16.3 0.1 1.3 1 0 0 1 1 1 1 Poxvirus A32 protein Roc PF08477.13 EMD67074.1 - 0.0071 16.5 0.1 0.016 15.5 0.1 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase IIGP PF05049.13 EMD67074.1 - 0.011 14.8 0.0 0.019 14.0 0.0 1.4 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) AAA_24 PF13479.6 EMD67074.1 - 0.013 15.3 0.0 0.024 14.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EMD67074.1 - 0.015 15.7 0.3 0.047 14.1 0.0 2.0 2 1 0 2 2 2 0 AAA ATPase domain AIG1 PF04548.16 EMD67074.1 - 0.018 14.4 0.0 0.032 13.5 0.0 1.4 1 0 0 1 1 1 0 AIG1 family FOXP-CC PF16159.5 EMD67074.1 - 0.026 15.1 1.0 0.026 15.1 1.0 2.3 2 0 0 2 2 2 0 FOXP coiled-coil domain Ras PF00071.22 EMD67074.1 - 0.032 13.8 0.8 0.094 12.3 0.4 2.0 2 1 0 2 2 2 0 Ras family KAP_NTPase PF07693.14 EMD67074.1 - 0.033 13.4 0.0 0.046 13.0 0.0 1.6 1 1 0 1 1 1 0 KAP family P-loop domain Val_tRNA-synt_C PF10458.9 EMD67074.1 - 0.034 14.4 3.0 0.051 13.9 0.1 2.6 2 1 0 2 2 2 0 Valyl tRNA synthetase tRNA binding arm NACHT PF05729.12 EMD67074.1 - 0.056 13.4 0.0 0.097 12.6 0.0 1.4 1 0 0 1 1 1 0 NACHT domain ABC_tran PF00005.27 EMD67074.1 - 0.065 13.8 0.1 0.18 12.3 0.0 1.8 2 0 0 2 2 2 0 ABC transporter T2SSE PF00437.20 EMD67074.1 - 0.08 12.0 0.2 0.29 10.1 0.0 1.9 2 0 0 2 2 2 0 Type II/IV secretion system protein Sigma54_activat PF00158.26 EMD67074.1 - 0.084 12.6 0.0 0.16 11.6 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain PduV-EutP PF10662.9 EMD67074.1 - 0.11 12.2 0.3 4.3 7.1 0.3 2.4 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation ATP_bind_1 PF03029.17 EMD67074.1 - 0.15 11.9 0.5 13 5.5 0.1 2.6 2 1 0 2 2 2 0 Conserved hypothetical ATP binding protein Dynamin_N PF00350.23 EMD67074.1 - 0.36 10.9 5.5 2.9 7.9 0.1 3.0 2 1 1 3 3 3 0 Dynamin family HIP1_clath_bdg PF16515.5 EMD67074.1 - 2.7 8.6 8.2 1.1 9.9 3.2 2.3 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 SUIM_assoc PF16619.5 EMD67075.1 - 0.096 12.8 7.4 5.3 7.2 7.5 2.4 2 1 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 CDH-cyt PF16010.5 EMD67076.1 - 1.2e-48 165.3 2.4 1.6e-48 164.8 1.5 1.7 2 0 0 2 2 2 1 Cytochrome domain of cellobiose dehydrogenase GMC_oxred_N PF00732.19 EMD67076.1 - 1.2e-27 97.1 0.0 3.1e-27 95.7 0.0 1.8 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EMD67076.1 - 8.5e-20 71.7 0.1 8.5e-20 71.7 0.1 2.3 2 0 0 2 2 2 1 GMC oxidoreductase CBM_1 PF00734.18 EMD67076.1 - 1.9e-11 43.7 12.0 1.9e-11 43.7 12.0 2.4 2 0 0 2 2 2 1 Fungal cellulose binding domain FAD_binding_2 PF00890.24 EMD67076.1 - 8.3e-07 28.4 0.0 0.00094 18.4 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 EMD67076.1 - 0.0013 18.9 0.4 0.0054 16.9 0.0 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 EMD67076.1 - 0.0014 17.5 0.1 0.0022 16.7 0.1 1.3 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_2 PF07992.14 EMD67076.1 - 0.0039 16.5 0.2 0.0077 15.5 0.0 1.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EMD67076.1 - 0.01 15.1 0.1 0.02 14.2 0.1 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EMD67076.1 - 0.014 15.9 0.0 0.29 11.7 0.0 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EMD67076.1 - 0.016 14.8 0.9 0.12 12.0 0.3 2.5 2 1 0 2 2 2 0 FAD dependent oxidoreductase FAD_oxidored PF12831.7 EMD67076.1 - 0.023 14.0 0.0 0.2 11.0 0.0 2.1 2 0 0 2 2 2 0 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 EMD67076.1 - 0.038 13.0 0.1 0.058 12.4 0.1 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein DOMON PF03351.17 EMD67076.1 - 0.051 13.8 0.1 0.2 11.9 0.0 2.0 2 0 0 2 2 2 0 DOMON domain PSI PF01437.25 EMD67077.1 - 6.8e-05 23.3 5.7 0.00015 22.3 5.7 1.6 1 0 0 1 1 1 1 Plexin repeat PSI_integrin PF17205.3 EMD67077.1 - 1.2 8.9 8.1 2.5 7.9 8.1 1.5 1 0 0 1 1 1 0 Integrin plexin domain MFS_1 PF07690.16 EMD67079.1 - 2.6e-24 85.8 59.3 2.7e-24 85.8 44.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Tir_receptor_C PF07489.11 EMD67079.1 - 8.1 6.3 8.2 13 5.6 8.2 1.2 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) C-terminus Dicty_REP PF05086.12 EMD67079.1 - 10 4.0 7.0 13 3.6 7.0 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein tRNA-synt_1e PF01406.19 EMD67080.1 - 1.1e-116 389.4 0.0 1.9e-116 388.6 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.11 EMD67080.1 - 0.00082 18.2 0.2 1.2 7.8 0.0 2.5 2 0 0 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1c PF00749.21 EMD67080.1 - 0.0087 15.0 0.0 0.0087 15.0 0.0 2.0 2 0 0 2 2 2 1 tRNA synthetases class I (E and Q), catalytic domain GCD14 PF08704.10 EMD67081.1 - 6.9e-62 209.3 0.2 8.7e-22 78.0 0.0 3.9 3 1 0 3 3 3 3 tRNA methyltransferase complex GCD14 subunit PhoD PF09423.10 EMD67082.1 - 8.1e-40 136.9 0.0 1.6e-39 136.0 0.0 1.5 1 1 0 1 1 1 1 PhoD-like phosphatase Melittin PF01372.17 EMD67082.1 - 0.18 11.8 2.1 7.5 6.7 0.7 3.0 2 0 0 2 2 2 0 Melittin HET PF06985.11 EMD67083.1 - 1.8e-10 41.4 7.5 3.4e-09 37.2 1.3 2.6 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) Transferase PF02458.15 EMD67086.1 - 7.7e-29 100.6 0.0 6.1e-25 87.8 0.0 2.8 2 1 0 2 2 2 2 Transferase family ABC2_membrane PF01061.24 EMD67087.1 - 1.1e-84 283.0 44.4 2.4e-48 164.3 16.2 2.6 2 0 0 2 2 2 2 ABC-2 type transporter ABC_tran PF00005.27 EMD67087.1 - 5.9e-41 140.2 0.0 6.1e-19 68.9 0.0 2.7 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.12 EMD67087.1 - 1.1e-23 82.9 0.0 1.1e-23 82.9 0.0 3.3 4 0 0 4 4 2 2 CDR ABC transporter ABC2_membrane_3 PF12698.7 EMD67087.1 - 7.3e-13 48.3 30.2 3.3e-08 33.0 13.3 2.4 2 0 0 2 2 2 2 ABC-2 family transporter protein ABC_trans_N PF14510.6 EMD67087.1 - 4.4e-10 40.0 0.1 1.4e-09 38.4 0.1 1.9 1 0 0 1 1 1 1 ABC-transporter N-terminal AAA_16 PF13191.6 EMD67087.1 - 1.9e-06 28.4 0.7 0.0027 18.1 0.1 3.1 2 1 1 3 3 3 1 AAA ATPase domain RsgA_GTPase PF03193.16 EMD67087.1 - 8e-06 25.9 0.3 0.012 15.5 0.1 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_22 PF13401.6 EMD67087.1 - 2.3e-05 24.7 0.3 0.33 11.2 0.1 3.5 3 2 0 4 4 3 2 AAA domain AAA_25 PF13481.6 EMD67087.1 - 3.9e-05 23.3 0.1 0.00085 19.0 0.1 2.3 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 EMD67087.1 - 0.0012 18.6 0.3 0.084 12.6 0.2 2.9 2 0 0 2 2 2 1 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 EMD67087.1 - 0.0052 16.9 0.2 1.5 8.9 0.0 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_18 PF13238.6 EMD67087.1 - 0.0091 16.5 0.5 3 8.4 0.0 3.0 3 0 0 3 3 3 1 AAA domain AAA_30 PF13604.6 EMD67087.1 - 0.016 14.9 0.4 3.2 7.4 0.4 2.8 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 EMD67087.1 - 0.021 15.0 1.1 1.1 9.5 0.5 2.7 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 EMD67087.1 - 0.028 14.0 0.8 4.7 6.8 0.3 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain RNA_helicase PF00910.22 EMD67087.1 - 0.029 14.8 0.0 13 6.2 0.1 3.1 3 0 0 3 3 3 0 RNA helicase AAA_33 PF13671.6 EMD67087.1 - 0.03 14.5 1.3 2.2 8.5 0.0 3.0 3 0 0 3 3 3 0 AAA domain AAA PF00004.29 EMD67087.1 - 0.041 14.3 0.0 11 6.4 0.0 2.8 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) PduV-EutP PF10662.9 EMD67087.1 - 0.068 12.9 0.3 5.1 6.8 0.2 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Zeta_toxin PF06414.12 EMD67087.1 - 0.083 12.2 0.6 7 5.9 0.3 2.4 2 0 0 2 2 2 0 Zeta toxin NACHT PF05729.12 EMD67087.1 - 0.098 12.6 0.1 2.9 7.8 0.1 2.4 2 0 0 2 2 2 0 NACHT domain Zn_clus PF00172.18 EMD67088.1 - 1.3e-07 31.6 9.6 2.8e-07 30.5 9.6 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EMD67088.1 - 4.4e-06 25.9 1.7 5.6e-06 25.6 0.5 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain Tat PF00539.18 EMD67088.1 - 1.2 9.4 8.5 2.7 8.2 8.5 1.6 1 0 0 1 1 1 0 Transactivating regulatory protein (Tat) DUF3425 PF11905.8 EMD67090.1 - 1.8e-08 34.4 0.1 2.4e-08 34.0 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) Peptidase_S15 PF02129.18 EMD67091.1 - 8.5e-39 133.8 6.2 2.3e-34 119.2 0.1 2.1 1 1 1 2 2 2 2 X-Pro dipeptidyl-peptidase (S15 family) PepX_C PF08530.10 EMD67091.1 - 3.1e-38 131.9 0.0 4.8e-38 131.3 0.0 1.3 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain PhyH PF05721.13 EMD67092.1 - 3.4e-06 27.5 0.1 9.5e-06 26.0 0.1 1.7 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) DUF1479 PF07350.12 EMD67092.1 - 7.7e-05 21.6 0.0 0.94 8.2 0.0 3.0 3 0 0 3 3 3 2 Protein of unknown function (DUF1479) 2OG-FeII_Oxy_5 PF13759.6 EMD67092.1 - 0.0038 17.6 0.0 0.0076 16.6 0.0 1.4 1 0 0 1 1 1 1 Putative 2OG-Fe(II) oxygenase MFS_1 PF07690.16 EMD67093.1 - 1.3e-19 70.3 26.0 1.3e-19 70.3 26.0 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EMD67093.1 - 5.8e-06 25.4 1.2 5.8e-06 25.4 1.2 3.2 2 1 1 3 3 3 2 Sugar (and other) transporter Spore_YhaL PF14147.6 EMD67093.1 - 0.19 11.4 0.5 0.62 9.8 0.5 1.8 1 0 0 1 1 1 0 Sporulation protein YhaL DUF4191 PF13829.6 EMD67093.1 - 4.1 6.7 9.3 1.1 8.5 5.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4191) Fungal_trans PF04082.18 EMD67094.1 - 1.1e-10 41.1 0.3 3.3e-10 39.4 0.0 1.9 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD67094.1 - 3.3e-08 33.5 8.0 6.6e-08 32.6 8.0 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FAD_binding_3 PF01494.19 EMD67095.1 - 8.6e-23 81.1 0.0 1.2e-22 80.7 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EMD67095.1 - 2.9e-06 26.7 0.4 0.00076 18.8 0.2 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EMD67095.1 - 1.8e-05 23.9 1.0 0.00058 19.0 0.2 2.7 2 1 0 2 2 2 1 Lycopene cyclase protein Pyr_redox_3 PF13738.6 EMD67095.1 - 0.00017 21.0 0.1 0.027 13.7 1.2 2.2 1 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EMD67095.1 - 0.0018 18.4 0.1 0.0055 16.9 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EMD67095.1 - 0.0025 17.0 0.6 0.005 16.0 0.6 1.5 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 EMD67095.1 - 0.0039 15.9 0.9 0.007 15.1 0.9 1.4 1 0 0 1 1 1 1 HI0933-like protein DAO PF01266.24 EMD67095.1 - 0.023 14.3 0.3 0.05 13.2 0.3 1.5 1 0 0 1 1 1 0 FAD dependent oxidoreductase 3HCDH_N PF02737.18 EMD67095.1 - 0.024 14.5 0.3 0.041 13.8 0.3 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_9 PF13454.6 EMD67095.1 - 0.039 13.9 0.0 6.2 6.8 0.1 2.3 2 0 0 2 2 2 0 FAD-NAD(P)-binding GIDA PF01134.22 EMD67095.1 - 0.05 12.7 0.5 0.073 12.1 0.5 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A F420_oxidored PF03807.17 EMD67095.1 - 0.064 13.8 0.1 0.13 12.8 0.1 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent FAD_oxidored PF12831.7 EMD67095.1 - 0.13 11.5 1.2 0.2 11.0 1.2 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase Pkinase PF00069.25 EMD67097.1 - 1.3e-23 83.7 0.0 1.6e-23 83.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD67097.1 - 2.3e-08 33.6 0.0 2.3e-08 33.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EMD67097.1 - 0.0071 15.3 0.0 0.0096 14.9 0.0 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EMD67097.1 - 0.011 15.0 0.0 0.018 14.4 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EMD67097.1 - 0.018 15.0 0.0 0.039 13.9 0.0 1.5 2 0 0 2 2 2 0 Phosphotransferase enzyme family Kinase-like PF14531.6 EMD67097.1 - 0.022 14.1 0.1 0.039 13.3 0.1 1.7 1 1 0 1 1 1 0 Kinase-like Pkinase_fungal PF17667.1 EMD67097.1 - 0.026 13.3 0.0 0.031 13.0 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase Seadorna_VP7 PF07387.11 EMD67097.1 - 0.16 11.0 0.0 0.2 10.7 0.0 1.1 1 0 0 1 1 1 0 Seadornavirus VP7 Choline_kinase PF01633.20 EMD67097.1 - 0.24 11.0 0.0 0.35 10.4 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase ACT_7 PF13840.6 EMD67099.1 - 1.2e-26 92.2 0.0 7.1e-18 64.2 0.0 2.4 2 0 0 2 2 2 2 ACT domain GAS PF13851.6 EMD67100.1 - 0.001 18.4 2.9 0.001 18.4 2.9 7.3 2 1 5 7 7 7 4 Growth-arrest specific micro-tubule binding TolA_bind_tri PF16331.5 EMD67100.1 - 0.011 15.8 6.2 0.011 15.8 6.2 8.7 4 2 7 11 11 11 0 TolA binding protein trimerisation FlxA PF14282.6 EMD67100.1 - 0.012 15.6 11.8 0.012 15.6 11.8 9.0 1 1 7 9 9 9 0 FlxA-like protein Filament PF00038.21 EMD67100.1 - 0.65 9.5 99.8 0.0064 16.1 37.0 5.8 1 1 3 4 4 4 0 Intermediate filament protein GRP PF07172.11 EMD67101.1 - 0.56 10.9 12.0 0.11 13.2 8.8 1.5 2 0 0 2 2 2 0 Glycine rich protein family Nop10p PF04135.12 EMD67102.1 - 1.3e-18 66.8 0.9 1.5e-18 66.5 0.9 1.1 1 0 0 1 1 1 1 Nucleolar RNA-binding protein, Nop10p family AMP-binding PF00501.28 EMD67103.1 - 5.2e-42 143.9 0.0 7.4e-42 143.4 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EMD67103.1 - 0.0078 17.2 0.0 0.017 16.1 0.0 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Peptidase_M28 PF04389.17 EMD67106.1 - 2.7e-11 43.5 1.5 0.0012 18.5 0.6 3.2 1 1 2 3 3 3 3 Peptidase family M28 PA PF02225.22 EMD67106.1 - 0.00063 19.7 0.0 0.0013 18.7 0.0 1.5 1 0 0 1 1 1 1 PA domain Carn_acyltransf PF00755.20 EMD67108.1 - 0.14 10.7 0.1 0.14 10.8 0.1 1.0 1 0 0 1 1 1 0 Choline/Carnitine o-acyltransferase CorA PF01544.18 EMD67109.1 - 0.00014 21.3 10.0 0.00033 20.1 10.0 1.8 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein DUF4010 PF13194.6 EMD67109.1 - 0.011 15.4 4.0 0.017 14.8 4.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4010) Phage_holin_3_6 PF07332.11 EMD67109.1 - 0.016 15.2 0.9 0.028 14.5 0.9 1.3 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III DUF996 PF06195.13 EMD67109.1 - 0.023 15.0 2.1 0.023 15.0 2.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF996) Death PF00531.22 EMD67109.1 - 0.067 13.4 0.0 0.2 11.9 0.0 1.9 1 0 0 1 1 1 0 Death domain SieB PF14163.6 EMD67109.1 - 0.33 10.4 3.2 0.62 9.6 3.2 1.4 1 0 0 1 1 1 0 Super-infection exclusion protein B MgtE PF01769.16 EMD67109.1 - 0.35 11.3 5.5 0.79 10.1 5.5 1.5 1 0 0 1 1 1 0 Divalent cation transporter RicinB_lectin_2 PF14200.6 EMD67110.1 - 1.6e-10 41.6 0.3 6e-05 23.7 0.0 2.1 1 1 1 2 2 2 2 Ricin-type beta-trefoil lectin domain-like Ricin_B_lectin PF00652.22 EMD67110.1 - 6.3e-09 36.2 0.0 3.5e-08 33.8 0.0 1.8 1 1 0 1 1 1 1 Ricin-type beta-trefoil lectin domain DUF2529 PF10740.9 EMD67110.1 - 0.071 12.7 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2529) MFS_1 PF07690.16 EMD67111.1 - 6.1e-43 147.1 44.4 7.3e-40 137.0 43.6 2.5 2 1 0 2 2 2 2 Major Facilitator Superfamily PALP PF00291.25 EMD67112.1 - 1.6e-33 116.4 0.0 5.7e-33 114.6 0.0 1.8 2 0 0 2 2 2 1 Pyridoxal-phosphate dependent enzyme Rhodanese PF00581.20 EMD67112.1 - 1.8e-06 28.4 0.0 5.2e-06 26.9 0.0 1.8 2 0 0 2 2 2 1 Rhodanese-like domain adh_short PF00106.25 EMD67113.1 - 2.6e-32 111.9 0.0 8.4e-32 110.2 0.0 1.8 2 1 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD67113.1 - 6.8e-24 84.7 0.0 1e-23 84.2 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD67113.1 - 6.8e-11 42.4 0.0 1e-10 41.8 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EMD67113.1 - 7.6e-06 25.6 0.0 1.2e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EMD67113.1 - 0.00086 19.2 0.0 0.0014 18.5 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding RmlD_sub_bind PF04321.17 EMD67113.1 - 0.0041 16.3 0.0 0.0061 15.7 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain GDP_Man_Dehyd PF16363.5 EMD67113.1 - 0.022 14.2 0.0 0.031 13.7 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Parvo_NS1 PF01057.17 EMD67113.1 - 0.064 12.3 0.0 0.09 11.8 0.0 1.1 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 HET PF06985.11 EMD67114.1 - 8.9e-34 116.9 0.1 1.1e-33 116.6 0.1 1.1 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) DUF815 PF05673.13 EMD67114.1 - 0.17 11.1 0.0 0.22 10.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF815) DHHA2 PF02833.14 EMD67119.1 - 8.4e-39 133.0 0.3 1.8e-38 131.9 0.3 1.6 1 0 0 1 1 1 1 DHHA2 domain DHH PF01368.20 EMD67119.1 - 8.8e-09 35.5 0.4 3e-08 33.8 0.1 1.8 2 0 0 2 2 2 1 DHH family Abhydrolase_2 PF02230.16 EMD67120.1 - 1.8e-21 77.0 0.0 2.3e-21 76.6 0.0 1.0 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase DLH PF01738.18 EMD67120.1 - 3.1e-05 23.6 0.0 4e-05 23.3 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_1 PF00561.20 EMD67120.1 - 0.00087 19.0 0.2 0.013 15.2 0.2 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EMD67120.1 - 0.0011 18.3 0.0 0.85 8.8 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EMD67120.1 - 0.0062 17.2 0.0 0.0071 17.0 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Palm_thioest PF02089.15 EMD67120.1 - 0.011 15.5 0.0 0.014 15.2 0.0 1.2 1 0 0 1 1 1 0 Palmitoyl protein thioesterase EXS PF03124.14 EMD67121.1 - 1.3e-76 258.1 13.9 9.6e-68 228.9 6.0 2.1 1 1 1 2 2 2 2 EXS family SPX PF03105.19 EMD67121.1 - 3.3e-74 251.1 9.6 3.3e-74 251.1 9.6 2.2 2 0 0 2 2 2 1 SPX domain DUF3759 PF12585.8 EMD67121.1 - 2.5e-38 130.0 8.6 7.2e-38 128.5 8.6 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF3759) MFS_1 PF07690.16 EMD67122.1 - 1.7e-30 106.1 19.2 1.7e-30 106.1 19.2 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EMD67122.1 - 6.9e-10 38.4 2.1 6.9e-10 38.4 2.1 3.3 2 2 1 3 3 3 2 Sugar (and other) transporter His_Phos_1 PF00300.22 EMD67125.1 - 1.9e-15 57.1 0.1 3.3e-15 56.3 0.0 1.4 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) DUF346 PF03984.13 EMD67126.1 - 0.00086 19.0 24.3 0.005 16.6 0.1 6.9 8 0 0 8 8 8 3 Repeat of unknown function (DUF346) Laterosporulin PF17861.1 EMD67126.1 - 0.004 17.5 0.1 23 5.5 0.0 4.9 6 0 0 6 6 6 1 Laterosporulin defensin-like peptide ANAPC8 PF04049.13 EMD67127.1 - 8.1e-53 178.2 0.0 1.5e-52 177.3 0.0 1.5 1 0 0 1 1 1 1 Anaphase promoting complex subunit 8 / Cdc23 TPR_1 PF00515.28 EMD67127.1 - 5.3e-23 79.8 5.7 0.0011 18.7 0.5 8.1 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_8 PF13181.6 EMD67127.1 - 1.6e-16 59.1 6.1 0.00083 19.4 0.0 7.6 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_2 PF07719.17 EMD67127.1 - 1.5e-11 43.5 18.5 1 9.6 0.1 8.6 9 0 0 9 9 8 5 Tetratricopeptide repeat TPR_14 PF13428.6 EMD67127.1 - 1.7e-10 40.8 18.4 0.037 14.8 0.0 8.4 7 1 1 8 8 8 3 Tetratricopeptide repeat TPR_16 PF13432.6 EMD67127.1 - 6.3e-10 39.5 4.5 5.7e-05 23.7 0.3 6.1 6 1 1 7 7 7 2 Tetratricopeptide repeat TPR_11 PF13414.6 EMD67127.1 - 2.8e-09 36.5 0.1 6e-06 25.8 0.0 4.4 4 1 1 5 5 5 1 TPR repeat ANAPC3 PF12895.7 EMD67127.1 - 2.5e-07 30.8 7.5 0.73 10.1 0.1 5.8 5 1 2 7 7 7 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 EMD67127.1 - 1.2e-06 28.9 5.1 0.23 12.0 0.0 6.0 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_17 PF13431.6 EMD67127.1 - 4.3e-06 26.7 1.8 3.3 8.3 0.0 6.2 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_9 PF13371.6 EMD67127.1 - 5.9e-05 23.1 1.2 5.4 7.3 0.0 4.7 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 EMD67127.1 - 8.8e-05 22.9 19.1 0.4 11.4 0.4 7.5 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_12 PF13424.6 EMD67127.1 - 0.00024 21.3 14.6 2.6 8.4 0.0 6.6 6 1 0 6 6 6 1 Tetratricopeptide repeat TPR_15 PF13429.6 EMD67127.1 - 0.0035 16.6 0.8 0.0035 16.6 0.8 2.8 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 EMD67127.1 - 0.0066 16.4 9.2 3 8.1 0.0 6.0 6 0 0 6 6 6 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EMD67127.1 - 0.072 13.2 0.3 17 5.6 0.1 3.9 4 0 0 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat Cnd1 PF12717.7 EMD67127.1 - 0.076 13.1 0.1 0.14 12.2 0.1 1.4 1 0 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 DUF3856 PF12968.7 EMD67127.1 - 0.1 12.7 0.2 1.6 8.8 0.0 2.8 1 1 1 2 2 2 0 Domain of Unknown Function (DUF3856) polyprenyl_synt PF00348.17 EMD67128.1 - 8.2e-94 313.4 0.0 1e-93 313.1 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase PfkB PF00294.24 EMD67129.1 - 3.7e-55 187.4 6.0 4.7e-55 187.0 6.0 1.1 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Glyco_hydro_7 PF00840.20 EMD67130.1 - 8.6e-193 640.9 13.5 9.8e-193 640.8 13.5 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 7 Phytase PF02333.15 EMD67131.1 - 8.4e-65 219.2 4.5 9e-65 219.1 2.6 1.7 2 0 0 2 2 2 1 Phytase EGF_2 PF07974.13 EMD67131.1 - 4.8e-06 26.8 27.4 0.0078 16.6 12.7 2.6 2 0 0 2 2 2 2 EGF-like domain EGF_alliinase PF04863.13 EMD67131.1 - 0.89 10.0 21.6 12 6.4 5.7 3.1 1 1 1 2 2 2 0 Alliinase EGF-like domain TGT PF01702.18 EMD67132.1 - 3.8e-55 187.4 0.0 4.8e-55 187.1 0.0 1.0 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase FMO-like PF00743.19 EMD67133.1 - 2e-10 39.7 0.0 5.1e-09 35.1 0.0 2.3 2 0 0 2 2 2 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EMD67133.1 - 1.1e-07 31.4 0.0 3e-07 30.0 0.0 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EMD67133.1 - 2.5e-07 30.2 0.0 0.00087 18.5 0.0 2.3 2 0 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.14 EMD67133.1 - 9.9e-07 28.3 0.0 7.5e-06 25.4 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EMD67133.1 - 1e-06 28.9 0.0 2.8e-06 27.4 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EMD67133.1 - 0.0014 18.3 0.0 0.14 11.7 0.0 2.4 2 0 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.17 EMD67133.1 - 0.0026 17.0 0.0 0.0056 15.9 0.0 1.5 1 0 0 1 1 1 1 Thi4 family NAD_binding_9 PF13454.6 EMD67133.1 - 0.0027 17.7 0.9 0.028 14.4 0.2 2.8 3 1 0 3 3 3 1 FAD-NAD(P)-binding Lycopene_cycl PF05834.12 EMD67133.1 - 0.088 11.8 0.0 0.17 10.9 0.0 1.4 1 0 0 1 1 1 0 Lycopene cyclase protein PglD_N PF17836.1 EMD67133.1 - 0.089 13.4 0.0 2.7 8.7 0.0 2.5 2 0 0 2 2 2 0 PglD N-terminal domain HI0933_like PF03486.14 EMD67133.1 - 0.19 10.4 0.2 2.1 6.9 0.1 2.3 3 0 0 3 3 3 0 HI0933-like protein F-box-like PF12937.7 EMD67135.1 - 8.3e-07 28.8 0.1 2.9e-06 27.1 0.0 2.0 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EMD67135.1 - 0.00079 19.2 0.0 0.0023 17.8 0.0 1.8 1 0 0 1 1 1 1 F-box domain IDO PF01231.18 EMD67135.1 - 0.12 11.1 0.0 0.21 10.3 0.0 1.3 1 0 0 1 1 1 0 Indoleamine 2,3-dioxygenase Egh16-like PF11327.8 EMD67137.1 - 3.4e-49 167.8 6.2 3.4e-49 167.8 6.2 2.0 2 1 0 2 2 2 1 Egh16-like virulence factor DUF4175 PF13779.6 EMD67137.1 - 0.76 7.6 21.8 1.1 7.0 21.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) DUF4748 PF15932.5 EMD67138.1 - 1.8e-16 59.6 0.2 2.9e-16 58.9 0.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4748) NPCC PF08058.11 EMD67139.1 - 1.5e-30 105.9 0.0 2e-30 105.5 0.0 1.2 1 0 0 1 1 1 1 Nuclear pore complex component AMP-binding PF00501.28 EMD67140.1 - 3.7e-15 55.4 0.1 3.6e-07 29.1 0.1 2.1 2 0 0 2 2 2 2 AMP-binding enzyme Transp_cyt_pur PF02133.15 EMD67141.1 - 1.4e-99 333.8 47.1 1.7e-99 333.6 47.1 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Adap_comp_sub PF00928.21 EMD67143.1 - 6.2e-92 307.7 0.0 8.4e-92 307.3 0.0 1.2 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 EMD67143.1 - 2.7e-09 37.1 0.3 4.4e-09 36.4 0.3 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain zf-RING_UBOX PF13445.6 EMD67144.1 - 1.3e-07 31.5 3.9 2.7e-07 30.5 3.9 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 EMD67144.1 - 1.9e-06 28.1 7.4 1.6e-05 25.1 7.4 2.6 1 1 0 1 1 1 1 Ring finger domain FYVE PF01363.21 EMD67144.1 - 8.7e-05 22.6 1.0 0.00031 20.8 1.0 1.9 1 1 0 1 1 1 1 FYVE zinc finger Prok-RING_4 PF14447.6 EMD67144.1 - 9.6e-05 22.2 5.0 0.00049 19.9 0.6 2.6 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 EMD67144.1 - 0.0003 20.6 4.5 0.00085 19.2 4.5 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EMD67144.1 - 0.00058 19.7 6.1 0.0052 16.6 1.1 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EMD67144.1 - 0.00085 19.6 7.0 0.00085 19.6 7.0 2.2 2 0 0 2 2 2 1 RING-H2 zinc finger domain Zn_ribbon_17 PF17120.5 EMD67144.1 - 0.018 14.7 1.5 0.49 10.0 0.3 2.8 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type zf-RING_5 PF14634.6 EMD67144.1 - 0.035 14.1 8.6 0.79 9.7 9.1 2.6 1 1 1 2 2 2 0 zinc-RING finger domain zf-ANAPC11 PF12861.7 EMD67144.1 - 0.057 13.5 4.5 0.19 11.8 4.5 1.9 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Pellino PF04710.14 EMD67144.1 - 0.083 11.6 0.9 0.13 10.9 0.9 1.3 1 0 0 1 1 1 0 Pellino MIS13 PF08202.11 EMD67144.1 - 0.13 11.6 0.0 0.19 11.0 0.0 1.2 1 0 0 1 1 1 0 Mis12-Mtw1 protein family zf-RING_4 PF14570.6 EMD67144.1 - 1.2 9.0 5.9 4.2 7.2 0.5 2.5 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain FANCL_C PF11793.8 EMD67144.1 - 1.6 9.0 5.2 7.3 6.9 5.2 2.2 1 1 0 1 1 1 0 FANCL C-terminal domain zf-C3HC4_2 PF13923.6 EMD67144.1 - 4.5 7.2 12.3 1.6 8.6 5.2 3.2 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) PP2C PF00481.21 EMD67145.1 - 6.8e-35 120.9 0.2 9.6e-35 120.4 0.2 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 EMD67145.1 - 3e-05 23.8 1.2 0.021 14.5 0.0 2.1 2 0 0 2 2 2 2 Protein phosphatase 2C SpoIIE PF07228.12 EMD67145.1 - 0.00097 19.1 0.4 0.86 9.5 0.0 2.3 2 0 0 2 2 2 2 Stage II sporulation protein E (SpoIIE) NMO PF03060.15 EMD67148.1 - 1.1e-56 192.6 0.7 1.1e-54 186.1 0.7 2.0 1 1 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.25 EMD67148.1 - 1.9e-13 50.2 0.0 1.2e-11 44.2 0.0 2.2 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.18 EMD67148.1 - 0.00025 20.2 0.2 0.00044 19.4 0.2 1.4 1 0 0 1 1 1 1 FMN-dependent dehydrogenase adh_short PF00106.25 EMD67149.1 - 1.5e-43 148.6 0.1 1.9e-43 148.2 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD67149.1 - 2.4e-30 105.9 0.0 2.9e-30 105.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF1776 PF08643.10 EMD67149.1 - 6.9e-06 25.6 0.0 0.00014 21.3 0.0 2.6 1 1 0 1 1 1 1 Fungal family of unknown function (DUF1776) DUF1409 PF07197.12 EMD67149.1 - 0.063 13.2 0.5 5.8 6.9 0.0 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF1409) NmrA PF05368.13 EMD67149.1 - 0.11 12.0 0.0 0.21 11.1 0.0 1.4 1 0 0 1 1 1 0 NmrA-like family Epimerase PF01370.21 EMD67149.1 - 0.13 11.7 0.1 0.31 10.5 0.0 1.6 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family NAD_binding_2 PF03446.15 EMD67149.1 - 0.13 12.4 0.0 0.3 11.3 0.0 1.6 1 1 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase MFS_1 PF07690.16 EMD67150.1 - 6.1e-36 124.1 22.6 1.7e-35 122.6 22.3 1.7 2 0 0 2 2 2 1 Major Facilitator Superfamily MFS_1_like PF12832.7 EMD67150.1 - 0.018 13.9 0.1 0.018 13.9 0.1 2.0 2 1 1 3 3 3 0 MFS_1 like family SpoVAB PF13782.6 EMD67150.1 - 0.04 14.2 1.2 0.04 14.2 1.2 2.1 2 0 0 2 2 2 0 Stage V sporulation protein AB TauD PF02668.16 EMD67152.1 - 8e-12 45.5 0.3 2.9e-11 43.7 0.3 1.7 1 1 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Methyltransf_2 PF00891.18 EMD67153.1 - 9.9e-18 64.2 0.0 1.2e-17 63.9 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_25 PF13649.6 EMD67153.1 - 9.6e-05 23.0 0.0 0.00035 21.2 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EMD67153.1 - 0.016 15.0 0.0 0.024 14.4 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 EMD67153.1 - 0.02 14.7 0.0 0.036 13.9 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.12 EMD67153.1 - 0.1 13.4 0.0 0.31 11.8 0.0 1.8 2 1 0 2 2 2 0 Methyltransferase domain Dimerisation PF08100.11 EMD67154.1 - 0.00035 20.5 0.0 0.00076 19.5 0.0 1.6 1 0 0 1 1 1 1 Dimerisation domain MarR_2 PF12802.7 EMD67154.1 - 0.01 15.7 0.0 0.021 14.7 0.0 1.5 1 0 0 1 1 1 0 MarR family TetR_N PF00440.23 EMD67154.1 - 0.033 14.0 0.0 0.062 13.1 0.0 1.4 1 0 0 1 1 1 0 Bacterial regulatory proteins, tetR family MarR PF01047.22 EMD67154.1 - 0.074 13.0 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 MarR family Zn_clus PF00172.18 EMD67155.1 - 1.6e-10 40.9 13.0 5e-10 39.3 13.0 1.9 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Epimerase PF01370.21 EMD67156.1 - 1.5e-20 73.7 0.3 4.5e-20 72.1 0.3 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EMD67156.1 - 2.1e-15 56.5 0.0 1.8e-14 53.4 0.0 2.0 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 EMD67156.1 - 1.3e-14 54.3 0.2 9e-14 51.6 0.2 2.0 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 EMD67156.1 - 1.6e-11 43.9 1.1 5.7e-10 38.8 1.1 2.1 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.6 EMD67156.1 - 7.1e-10 39.1 2.3 2.4e-09 37.3 2.3 1.9 1 1 0 1 1 1 1 NAD(P)H-binding Polysacc_synt_2 PF02719.15 EMD67156.1 - 1.4e-08 34.2 0.0 1.9e-08 33.8 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NmrA PF05368.13 EMD67156.1 - 2.6e-07 30.4 1.4 4e-07 29.8 1.0 1.5 2 0 0 2 2 2 1 NmrA-like family adh_short PF00106.25 EMD67156.1 - 0.0021 17.6 0.3 0.047 13.2 0.1 2.4 2 1 0 2 2 2 1 short chain dehydrogenase KR PF08659.10 EMD67156.1 - 0.018 15.0 1.7 0.68 9.8 1.7 2.3 1 1 0 1 1 1 0 KR domain RmlD_sub_bind PF04321.17 EMD67156.1 - 0.054 12.6 0.0 0.1 11.7 0.0 1.4 1 0 0 1 1 1 0 RmlD substrate binding domain adh_short_C2 PF13561.6 EMD67158.1 - 3.4e-45 154.4 0.1 3.8e-45 154.3 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EMD67158.1 - 6e-32 110.7 0.0 7.8e-32 110.3 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EMD67158.1 - 0.00017 21.6 0.1 0.00027 20.9 0.1 1.3 1 0 0 1 1 1 1 KR domain NmrA PF05368.13 EMD67159.1 - 1.6e-45 155.5 0.0 1.9e-45 155.2 0.0 1.0 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EMD67159.1 - 7.8e-13 48.7 0.0 1.1e-12 48.3 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding TrkA_N PF02254.18 EMD67159.1 - 9.6e-07 29.1 0.1 1.4e-06 28.5 0.1 1.3 1 0 0 1 1 1 1 TrkA-N domain Epimerase PF01370.21 EMD67159.1 - 1.1e-06 28.3 0.0 1.5e-06 27.9 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EMD67159.1 - 4.8e-05 22.5 0.0 7e-05 22.0 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family adh_short PF00106.25 EMD67159.1 - 7.7e-05 22.2 0.6 0.00011 21.7 0.6 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EMD67159.1 - 0.00089 19.2 0.2 0.0015 18.5 0.2 1.3 1 0 0 1 1 1 1 KR domain F420_oxidored PF03807.17 EMD67159.1 - 0.0025 18.4 0.3 0.0049 17.4 0.3 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent GDP_Man_Dehyd PF16363.5 EMD67159.1 - 0.046 13.1 0.0 0.061 12.7 0.0 1.1 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase adh_short_C2 PF13561.6 EMD67159.1 - 0.056 13.0 0.3 0.08 12.5 0.3 1.2 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase PALP PF00291.25 EMD67159.1 - 0.059 12.8 0.3 0.12 11.8 0.1 1.5 2 0 0 2 2 2 0 Pyridoxal-phosphate dependent enzyme TauD PF02668.16 EMD67160.1 - 1.3e-41 143.2 0.0 1.9e-41 142.7 0.0 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family UbiA PF01040.18 EMD67161.1 - 1.9e-32 112.6 14.2 2.4e-32 112.2 14.2 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family K_oxygenase PF13434.6 EMD67162.1 - 9.2e-07 28.3 0.0 9.1e-06 25.0 0.0 2.0 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 EMD67162.1 - 0.00016 21.9 0.4 0.00038 20.6 0.4 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain 2-Hacid_dh_C PF02826.19 EMD67162.1 - 0.006 16.0 0.0 0.46 9.8 0.0 2.3 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 EMD67162.1 - 0.02 14.9 0.0 2.6 8.1 0.0 2.4 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase FMO-like PF00743.19 EMD67162.1 - 0.038 12.4 0.0 0.096 11.1 0.0 1.6 2 0 0 2 2 2 0 Flavin-binding monooxygenase-like DAO PF01266.24 EMD67162.1 - 0.046 13.3 0.3 0.17 11.5 0.2 2.0 2 0 0 2 2 2 0 FAD dependent oxidoreductase NAD_binding_7 PF13241.6 EMD67162.1 - 0.36 11.3 0.9 24 5.5 0.1 3.3 3 0 0 3 3 3 0 Putative NAD(P)-binding DUF2951 PF11166.8 EMD67164.1 - 0.082 13.1 0.6 0.098 12.9 0.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2951) Cdc13_OB4_dimer PF18233.1 EMD67164.1 - 0.083 13.0 0.2 0.16 12.1 0.0 1.5 2 0 0 2 2 2 0 Cdc13 OB4 dimerization domain ERCC3_RAD25_C PF16203.5 EMD67165.1 - 2.4e-120 400.3 0.7 4.3e-120 399.5 0.7 1.4 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Helicase_C_3 PF13625.6 EMD67165.1 - 1.5e-31 109.2 0.1 1.1e-30 106.4 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EMD67165.1 - 9.4e-16 58.3 0.0 2e-15 57.2 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EMD67165.1 - 1.7e-13 50.9 0.3 8.2e-13 48.7 0.1 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 EMD67165.1 - 5.3e-06 25.4 0.0 7.8e-06 24.8 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain SBP_bac_6 PF13343.6 EMD67165.1 - 0.016 14.6 0.0 0.057 12.8 0.0 1.8 2 0 0 2 2 2 0 Bacterial extracellular solute-binding protein Hid1 PF12722.7 EMD67166.1 - 0 1073.1 0.0 0 1072.9 0.0 1.0 1 0 0 1 1 1 1 High-temperature-induced dauer-formation protein Dymeclin PF09742.9 EMD67166.1 - 2.5e-114 383.0 0.0 3.1e-114 382.7 0.0 1.0 1 0 0 1 1 1 1 Dyggve-Melchior-Clausen syndrome protein EHN PF06441.12 EMD67167.1 - 1.8e-31 108.7 0.2 2.9e-31 108.0 0.2 1.3 1 0 0 1 1 1 1 Epoxide hydrolase N terminus Abhydrolase_1 PF00561.20 EMD67167.1 - 8.8e-08 32.1 0.0 1.7e-07 31.2 0.0 1.4 2 0 0 2 2 2 1 alpha/beta hydrolase fold SAM_decarbox PF01536.16 EMD67168.1 - 1.8e-130 435.1 0.0 3.1e-130 434.3 0.0 1.3 1 1 0 1 1 1 1 Adenosylmethionine decarboxylase Metallophos PF00149.28 EMD67170.1 - 2.2e-37 129.6 0.1 4.1e-37 128.7 0.1 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Glyco_hydro_61 PF03443.14 EMD67171.1 - 0.0013 18.7 0.0 0.002 18.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 LPMO_10 PF03067.15 EMD67171.1 - 0.005 17.5 0.1 0.01 16.5 0.1 1.5 1 0 0 1 1 1 1 Lytic polysaccharide mono-oxygenase, cellulose-degrading PRCC PF10253.9 EMD67171.1 - 0.053 14.3 1.9 0.13 13.0 1.9 1.6 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting DUF3433 PF11915.8 EMD67172.1 - 2.7e-38 130.3 18.2 1e-22 80.4 0.8 3.6 4 0 0 4 4 4 2 Protein of unknown function (DUF3433) COX1 PF00115.20 EMD67172.1 - 6.6 5.5 11.6 0.19 10.5 0.1 3.2 4 0 0 4 4 4 0 Cytochrome C and Quinol oxidase polypeptide I RmlD_sub_bind PF04321.17 EMD67173.1 - 8.5e-52 176.0 0.0 1.1e-51 175.7 0.0 1.0 1 0 0 1 1 1 1 RmlD substrate binding domain Epimerase PF01370.21 EMD67173.1 - 2.8e-20 72.8 0.0 3.5e-20 72.5 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EMD67173.1 - 4.3e-10 39.5 0.0 1.2e-09 38.0 0.0 1.7 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 EMD67173.1 - 1.6e-09 37.3 0.5 1e-07 31.4 0.1 2.8 1 1 0 2 2 2 1 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.19 EMD67173.1 - 8.4e-09 34.8 0.0 5.4e-08 32.2 0.0 1.9 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 EMD67173.1 - 4.7e-08 32.5 0.0 1.1e-06 28.0 0.0 2.2 2 0 0 2 2 2 1 Male sterility protein NAD_binding_10 PF13460.6 EMD67173.1 - 0.075 12.9 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 NAD(P)H-binding NUDIX_2 PF13869.6 EMD67174.1 - 3.4e-80 268.1 0.0 4e-80 267.8 0.0 1.0 1 0 0 1 1 1 1 Nucleotide hydrolase GST_N PF02798.20 EMD67176.1 - 6.8e-09 35.9 0.0 1.2e-08 35.2 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EMD67176.1 - 4.3e-08 33.3 0.0 6.4e-08 32.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EMD67176.1 - 5.5e-08 33.1 0.0 9.4e-08 32.4 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EMD67176.1 - 1.3e-05 25.2 0.4 4.4e-05 23.4 0.2 2.0 1 1 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EMD67176.1 - 0.00039 20.6 0.0 0.00064 19.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 EMD67176.1 - 0.00048 20.4 0.0 0.0011 19.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain KLRAQ PF10205.9 EMD67177.1 - 0.0046 17.2 3.7 0.0086 16.3 3.7 1.5 1 0 0 1 1 1 1 Predicted coiled-coil domain-containing protein DUF4349 PF14257.6 EMD67177.1 - 0.033 13.6 1.3 0.058 12.8 1.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) ARA70 PF12489.8 EMD67177.1 - 0.047 13.9 4.6 0.095 12.9 4.6 1.4 1 0 0 1 1 1 0 Nuclear coactivator DUF3053 PF11254.8 EMD67177.1 - 0.11 12.1 0.6 0.16 11.5 0.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3053) Snapin_Pallidin PF14712.6 EMD67177.1 - 0.12 12.8 5.5 0.21 12.0 5.5 1.3 1 0 0 1 1 1 0 Snapin/Pallidin Helo_like_N PF17111.5 EMD67178.1 - 6.6e-12 45.3 0.4 1.3e-11 44.3 0.4 1.5 1 0 0 1 1 1 1 Fungal N-terminal domain of STAND proteins SesA PF17107.5 EMD67178.1 - 0.0025 18.0 0.1 0.011 16.0 0.1 2.1 2 1 0 2 2 2 1 N-terminal domain on NACHT_NTPase and P-loop NTPases zinc_ribbon_11 PF11682.8 EMD67178.1 - 0.018 15.1 0.6 0.041 13.9 0.6 1.6 1 0 0 1 1 1 0 Probable zinc-ribbon Phage_HK97_TLTM PF06120.11 EMD67178.1 - 0.028 13.6 0.3 0.06 12.5 0.3 1.5 1 0 0 1 1 1 0 Tail length tape measure protein Halogen_Hydrol PF10112.9 EMD67178.1 - 0.41 10.6 5.1 17 5.4 0.1 3.1 3 0 0 3 3 3 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein DUF1664 PF07889.12 EMD67178.1 - 1 9.4 3.1 8.2 6.5 0.3 3.3 2 1 2 4 4 4 0 Protein of unknown function (DUF1664) Plant_zn_clust PF10533.9 EMD67178.1 - 1.2 9.2 9.6 2.8 8.0 9.6 1.6 1 0 0 1 1 1 0 Plant zinc cluster domain MscS_porin PF12795.7 EMD67178.1 - 3.4 7.1 7.9 16 4.9 6.5 2.0 1 1 1 2 2 2 0 Mechanosensitive ion channel porin domain GIY-YIG PF01541.24 EMD67179.1 - 4.2e-21 75.0 0.0 1.9e-20 72.9 0.0 2.1 3 0 0 3 3 3 1 GIY-YIG catalytic domain FANCL_C PF11793.8 EMD67179.1 - 0.00014 22.0 2.4 0.0003 20.9 2.4 1.5 1 0 0 1 1 1 1 FANCL C-terminal domain PHD PF00628.29 EMD67179.1 - 0.00048 20.0 3.0 0.00095 19.0 3.0 1.5 1 0 0 1 1 1 1 PHD-finger zf-HC5HC2H PF13771.6 EMD67179.1 - 0.0011 19.2 2.7 0.0024 18.1 2.7 1.6 1 0 0 1 1 1 1 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 EMD67179.1 - 0.015 15.5 2.1 0.028 14.6 2.1 1.4 1 0 0 1 1 1 0 PHD-zinc-finger like domain Prok-RING_1 PF14446.6 EMD67179.1 - 0.1 12.5 3.2 0.1 12.5 1.0 2.0 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 Zn_ribbon_17 PF17120.5 EMD67179.1 - 0.11 12.2 2.5 0.26 11.0 2.5 1.7 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_2 PF13639.6 EMD67179.1 - 0.13 12.6 4.9 0.26 11.6 4.9 1.5 1 0 0 1 1 1 0 Ring finger domain T5orf172 PF10544.9 EMD67179.1 - 0.13 12.8 0.1 0.44 11.1 0.1 1.9 1 1 0 1 1 1 0 T5orf172 domain zf-RING-like PF08746.11 EMD67179.1 - 0.98 9.8 4.4 3.9 7.9 4.4 2.1 1 1 0 1 1 1 0 RING-like domain PLU-1 PF08429.11 EMD67180.1 - 1.4e-105 353.3 10.7 1.7e-103 346.4 9.1 2.3 2 0 0 2 2 2 2 PLU-1-like protein JmjC PF02373.22 EMD67180.1 - 1.1e-44 151.5 1.3 1.7e-44 150.9 0.1 2.1 2 0 0 2 2 2 1 JmjC domain, hydroxylase ARID PF01388.21 EMD67180.1 - 5.9e-23 81.4 0.3 3.3e-22 79.0 0.1 2.4 2 0 0 2 2 2 1 ARID/BRIGHT DNA binding domain PHD PF00628.29 EMD67180.1 - 4.5e-16 58.5 28.6 2.1e-08 33.9 7.9 3.1 3 0 0 3 3 3 2 PHD-finger JmjN PF02375.17 EMD67180.1 - 6.4e-16 58.0 1.2 1.5e-15 56.9 1.2 1.7 1 0 0 1 1 1 1 jmjN domain zf-C5HC2 PF02928.16 EMD67180.1 - 3.5e-13 49.7 5.9 8.6e-13 48.5 5.9 1.7 1 0 0 1 1 1 1 C5HC2 zinc finger Dynactin_p62 PF05502.13 EMD67180.1 - 0.055 12.2 0.5 0.14 10.9 0.5 1.6 1 0 0 1 1 1 0 Dynactin p62 family zf-PHD-like PF15446.6 EMD67180.1 - 0.22 11.1 6.2 4 7.0 0.7 2.5 2 0 0 2 2 2 0 PHD/FYVE-zinc-finger like domain C1_1 PF00130.22 EMD67180.1 - 0.68 9.9 9.8 0.71 9.8 3.0 2.9 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) 60KD_IMP PF02096.20 EMD67181.1 - 4.8e-13 49.3 0.2 6.5e-13 48.9 0.2 1.2 1 0 0 1 1 1 1 60Kd inner membrane protein TOM13 PF08219.11 EMD67182.1 - 3.9e-35 119.7 0.0 4.9e-35 119.4 0.0 1.1 1 0 0 1 1 1 1 Outer membrane protein TOM13 SEP PF08059.13 EMD67183.1 - 6.6e-27 93.9 0.0 1.4e-26 92.9 0.0 1.5 1 0 0 1 1 1 1 SEP domain UBX PF00789.20 EMD67183.1 - 2.6e-15 56.4 0.0 4e-15 55.8 0.0 1.3 1 0 0 1 1 1 1 UBX domain UBA_4 PF14555.6 EMD67183.1 - 1.1e-10 41.1 1.9 2e-10 40.3 1.9 1.4 1 0 0 1 1 1 1 UBA-like domain TAP_C PF03943.13 EMD67183.1 - 0.059 13.0 0.1 0.11 12.2 0.1 1.4 1 0 0 1 1 1 0 TAP C-terminal domain HTH_IclR PF09339.10 EMD67183.1 - 0.06 13.1 0.2 0.12 12.2 0.2 1.5 1 0 0 1 1 1 0 IclR helix-turn-helix domain DUF3405 PF11885.8 EMD67184.1 - 5.6e-186 619.1 10.9 7.1e-186 618.8 10.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3405) DUF1929 PF09118.11 EMD67185.1 - 2.3e-26 91.9 0.5 4.8e-26 90.9 0.5 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1929) PAN_1 PF00024.26 EMD67185.1 - 1.6e-15 56.8 1.8 4.5e-07 29.7 0.2 2.5 2 0 0 2 2 2 2 PAN domain Kelch_1 PF01344.25 EMD67185.1 - 1.3e-12 47.1 1.8 1.2e-06 28.0 0.1 5.0 4 1 0 4 4 4 2 Kelch motif Kelch_6 PF13964.6 EMD67185.1 - 5.6e-12 45.5 7.6 0.00056 20.1 0.1 5.6 3 3 2 5 5 5 3 Kelch motif Kelch_2 PF07646.15 EMD67185.1 - 6.4e-12 44.9 0.1 6.7e-06 25.9 0.0 5.0 4 1 0 4 4 4 1 Kelch motif Kelch_4 PF13418.6 EMD67185.1 - 5.3e-11 42.4 2.9 0.0009 19.2 0.1 4.9 4 0 0 4 4 4 2 Galactose oxidase, central domain Glyoxal_oxid_N PF07250.11 EMD67185.1 - 5.4e-06 25.8 0.0 0.0089 15.3 0.0 2.5 2 0 0 2 2 2 2 Glyoxal oxidase N-terminus Kelch_3 PF13415.6 EMD67185.1 - 8.3e-06 26.0 0.4 4.4 7.7 0.0 4.1 3 0 0 3 3 3 3 Galactose oxidase, central domain PAN_4 PF14295.6 EMD67185.1 - 0.00026 20.8 8.9 0.063 13.2 1.4 2.7 2 0 0 2 2 2 2 PAN domain PAN_3 PF08277.12 EMD67185.1 - 0.001 18.9 4.5 0.39 10.6 0.4 2.5 2 0 0 2 2 2 2 PAN-like domain Fungal_trans PF04082.18 EMD67186.1 - 3.4e-09 36.1 0.1 6.1e-09 35.3 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD67186.1 - 8.4e-09 35.4 8.0 1.9e-08 34.3 8.0 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pilt PF15453.6 EMD67186.1 - 0.33 10.3 3.1 0.54 9.6 3.1 1.3 1 0 0 1 1 1 0 Protein incorporated later into Tight Junctions GATase_5 PF13507.6 EMD67187.1 - 1.4e-100 335.7 0.0 2.2e-100 335.1 0.0 1.3 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain AIRS_C PF02769.22 EMD67187.1 - 1.2e-40 139.2 0.1 1.3e-25 90.4 0.0 2.5 2 0 0 2 2 2 2 AIR synthase related protein, C-terminal domain FGAR-AT_N PF18076.1 EMD67187.1 - 1.2e-31 109.0 0.0 2.4e-31 108.1 0.0 1.5 1 0 0 1 1 1 1 Formylglycinamide ribonucleotide amidotransferase N-terminal FGAR-AT_linker PF18072.1 EMD67187.1 - 4.1e-21 75.2 0.1 2e-20 73.1 0.1 2.2 2 0 0 2 2 2 1 Formylglycinamide ribonucleotide amidotransferase linker domain OCD_Mu_crystall PF02423.15 EMD67187.1 - 1.4e-15 57.0 0.0 3.4e-15 55.8 0.0 1.5 1 0 0 1 1 1 1 Ornithine cyclodeaminase/mu-crystallin family Shikimate_DH PF01488.20 EMD67187.1 - 1.7e-07 31.4 0.0 4.6e-07 30.0 0.0 1.7 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Sacchrp_dh_NADP PF03435.18 EMD67187.1 - 0.0056 16.9 0.0 0.013 15.8 0.0 1.6 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Staph_opine_DH PF10100.9 EMD67187.1 - 0.28 9.8 0.2 0.59 8.7 0.1 1.5 2 0 0 2 2 2 0 Staphylopine dehydrogenase FAD_binding_4 PF01565.23 EMD67190.1 - 1.7e-23 82.9 0.8 4e-23 81.7 0.8 1.7 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EMD67190.1 - 0.00044 20.3 0.0 0.0011 19.0 0.0 1.7 1 0 0 1 1 1 1 Berberine and berberine like Sirohm_synth_M PF14824.6 EMD67191.1 - 0.056 12.9 0.0 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 Sirohaem biosynthesis protein central DUF3278 PF11683.8 EMD67191.1 - 3.2 7.8 7.5 4 7.5 4.6 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3278) adh_short PF00106.25 EMD67194.1 - 7.3e-38 130.0 0.1 1e-37 129.5 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD67194.1 - 2.1e-27 96.2 0.1 2.7e-27 95.8 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD67194.1 - 1.3e-07 31.7 0.0 1.6e-07 31.4 0.0 1.2 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 EMD67194.1 - 0.0062 15.9 0.0 0.0095 15.3 0.0 1.3 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) Epimerase PF01370.21 EMD67194.1 - 0.16 11.4 0.0 1.2 8.5 0.0 1.9 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family Shikimate_DH PF01488.20 EMD67194.1 - 0.16 12.0 0.1 0.47 10.5 0.1 1.8 1 1 1 2 2 2 0 Shikimate / quinate 5-dehydrogenase Fungal_trans_2 PF11951.8 EMD67196.1 - 2.4e-56 191.2 4.7 3.1e-56 190.9 4.7 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD67196.1 - 2.8e-06 27.3 5.1 5.3e-06 26.5 5.1 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Mob_synth_C PF06463.13 EMD67196.1 - 0.024 14.5 1.0 0.15 12.0 0.3 2.5 3 0 0 3 3 3 0 Molybdenum Cofactor Synthesis C HscB_4_cys PF18256.1 EMD67196.1 - 5.7 6.8 7.3 12 5.9 7.3 1.4 1 0 0 1 1 1 0 Co-chaperone HscB tetracysteine metal binding motif CoA_transf_3 PF02515.17 EMD67197.1 - 1.8e-56 191.8 0.0 3.6e-56 190.9 0.0 1.4 1 1 0 1 1 1 1 CoA-transferase family III NAAA-beta PF15508.6 EMD67198.1 - 5.3e-07 29.8 0.0 1.1e-06 28.8 0.0 1.6 1 0 0 1 1 1 1 beta subunit of N-acylethanolamine-hydrolyzing acid amidase HTH_23 PF13384.6 EMD67198.1 - 0.017 14.9 0.2 0.46 10.4 0.0 2.6 2 0 0 2 2 2 0 Homeodomain-like domain Ribosomal_L27 PF01016.19 EMD67199.1 - 8e-29 99.5 0.1 1.6e-28 98.5 0.1 1.5 1 0 0 1 1 1 1 Ribosomal L27 protein RRN9 PF10680.9 EMD67199.1 - 0.037 14.3 0.7 0.095 13.0 0.6 1.8 1 1 0 1 1 1 0 RNA polymerase I specific transcription initiation factor Dynamin_M PF01031.20 EMD67200.1 - 2.3e-102 342.1 0.1 4.5e-102 341.1 0.1 1.5 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.23 EMD67200.1 - 2.3e-57 193.7 0.1 5.9e-57 192.4 0.1 1.7 1 0 0 1 1 1 1 Dynamin family GED PF02212.18 EMD67200.1 - 9.1e-31 105.9 5.2 2.2e-30 104.6 5.2 1.7 1 0 0 1 1 1 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 EMD67200.1 - 2e-05 24.6 0.4 8.7e-05 22.6 0.4 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_15 PF13175.6 EMD67200.1 - 0.095 12.4 0.9 5.8 6.5 0.0 2.4 2 0 0 2 2 2 0 AAA ATPase domain ATP-synt_ab PF00006.25 EMD67201.1 - 6.4e-110 365.8 0.0 8.6e-110 365.4 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_Xtn PF16886.5 EMD67201.1 - 1.1e-46 157.7 0.0 2.1e-46 156.7 0.0 1.5 1 0 0 1 1 1 1 ATPsynthase alpha/beta subunit N-term extension ATP-synt_ab_N PF02874.23 EMD67201.1 - 6.3e-16 58.7 1.3 1.2e-15 57.8 1.3 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain RRF PF01765.19 EMD67201.1 - 0.15 12.0 0.2 0.25 11.3 0.2 1.3 1 0 0 1 1 1 0 Ribosome recycling factor zf-CCHC PF00098.23 EMD67204.1 - 2.8e-06 27.2 2.3 4.2e-06 26.6 2.3 1.3 1 0 0 1 1 1 1 Zinc knuckle Cwf_Cwc_15 PF04889.12 EMD67204.1 - 7.8e-06 25.8 9.5 1e-05 25.4 9.5 1.1 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein TFIIF_alpha PF05793.12 EMD67204.1 - 0.0011 17.6 11.7 0.0014 17.4 11.7 1.2 1 0 0 1 1 1 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) zf-CCHC_3 PF13917.6 EMD67204.1 - 0.061 13.3 0.1 0.14 12.2 0.1 1.5 1 0 0 1 1 1 0 Zinc knuckle EthD PF07110.11 EMD67205.1 - 4.8e-19 69.3 0.3 6.3e-19 68.9 0.3 1.2 1 0 0 1 1 1 1 EthD domain MmlI PF09448.10 EMD67205.1 - 0.0027 18.1 0.2 0.004 17.6 0.2 1.3 1 1 0 1 1 1 1 Methylmuconolactone methyl-isomerase Benyvirus_P25 PF05744.11 EMD67205.1 - 0.025 13.9 0.2 0.03 13.6 0.2 1.1 1 0 0 1 1 1 0 Benyvirus P25/P26 protein dUTPase_2 PF08761.11 EMD67205.1 - 0.032 14.4 0.1 0.059 13.5 0.1 1.4 1 0 0 1 1 1 0 dUTPase Peptidase_M16_M PF16187.5 EMD67206.1 - 7.6e-95 317.4 0.1 1.4e-94 316.5 0.1 1.5 1 0 0 1 1 1 1 Middle or third domain of peptidase_M16 Peptidase_M16 PF00675.20 EMD67206.1 - 2.9e-33 114.9 1.2 3.2e-32 111.6 1.2 2.6 1 1 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 EMD67206.1 - 5.2e-31 108.1 0.3 4e-22 79.1 0.0 3.9 4 0 0 4 4 4 2 Peptidase M16 inactive domain FLILHELTA PF10306.9 EMD67207.1 - 2.2e-33 114.5 0.1 3.2e-33 114.0 0.1 1.2 1 0 0 1 1 1 1 Hypothetical protein FLILHELTA DUF1279 PF06916.13 EMD67207.1 - 0.12 13.0 0.0 0.17 12.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1279) UPF0047 PF01894.17 EMD67209.1 - 2.8e-37 127.4 0.1 5.7e-37 126.4 0.0 1.5 2 0 0 2 2 2 1 Uncharacterised protein family UPF0047 zf-CHCC PF10276.9 EMD67210.1 - 1.4e-15 57.1 2.1 2.2e-15 56.4 2.1 1.3 1 0 0 1 1 1 1 Zinc-finger domain AAL_decarboxy PF03306.13 EMD67211.1 - 5.1e-31 107.7 0.0 2.9e-15 56.2 0.0 2.0 1 1 1 2 2 2 2 Alpha-acetolactate decarboxylase HET PF06985.11 EMD67212.1 - 1.1e-05 25.8 0.1 2.1e-05 24.9 0.1 1.5 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Peptidase_M18 PF02127.15 EMD67213.1 - 3e-130 434.9 0.0 3.6e-130 434.6 0.0 1.0 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) IPP-2 PF04979.14 EMD67214.1 - 1.8e-23 83.7 13.9 3.2e-23 82.9 13.9 1.4 1 0 0 1 1 1 1 Protein phosphatase inhibitor 2 (IPP-2) IF4E PF01652.18 EMD67215.1 - 2.5e-53 180.1 0.8 2.9e-53 179.9 0.1 1.5 2 0 0 2 2 2 1 Eukaryotic initiation factor 4E Peptidase_C48 PF02902.19 EMD67216.1 - 1e-25 90.9 0.0 2.7e-25 89.5 0.0 1.7 1 1 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain GGACT PF06094.12 EMD67217.1 - 2.7e-16 60.2 0.0 6.2e-16 59.1 0.0 1.6 1 1 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like PQ-loop PF04193.14 EMD67218.1 - 3.2e-20 71.6 1.2 1.6e-12 47.0 0.1 2.5 2 0 0 2 2 2 2 PQ loop repeat Glyco_hydro_43 PF04616.14 EMD67219.1 - 1.6e-63 214.8 11.9 5.1e-56 190.1 1.3 2.8 2 1 1 3 3 3 3 Glycosyl hydrolases family 43 Glyco_hydro_32N PF00251.20 EMD67219.1 - 4.1e-10 39.7 0.5 0.0003 20.5 0.0 2.6 2 0 0 2 2 2 2 Glycosyl hydrolases family 32 N-terminal domain Alk_phosphatase PF00245.20 EMD67220.1 - 2.2e-77 260.7 0.1 2.8e-77 260.5 0.1 1.1 1 0 0 1 1 1 1 Alkaline phosphatase MNHE PF01899.16 EMD67220.1 - 0.0062 16.3 0.1 0.011 15.5 0.1 1.3 1 0 0 1 1 1 1 Na+/H+ ion antiporter subunit GCP_N_terminal PF17681.1 EMD67223.1 - 1.7e-38 133.0 2.5 1.9e-38 132.8 1.2 1.7 2 0 0 2 2 2 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 EMD67223.1 - 4e-18 65.9 3.7 1.4e-17 64.1 0.1 2.4 2 0 0 2 2 2 1 Gamma tubulin complex component C-terminal GCP5-Mod21 PF14609.6 EMD67223.1 - 0.00014 20.4 0.2 0.28 9.5 0.0 2.3 2 0 0 2 2 2 2 gamma-Tubulin ring complex non-core subunit mod21 NLRC4_HD2 PF17776.1 EMD67223.1 - 0.074 13.6 0.4 0.59 10.7 0.2 2.6 2 0 0 2 2 2 0 NLRC4 helical domain HD2 Glyco_transf_15 PF01793.16 EMD67224.1 - 4.1e-113 377.9 9.8 5.1e-113 377.6 9.8 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase Pkinase PF00069.25 EMD67225.1 - 3.5e-25 88.9 0.0 5.6e-25 88.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain HET PF06985.11 EMD67225.1 - 8.7e-23 81.3 0.0 2.2e-22 80.0 0.0 1.8 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Frigida PF07899.11 EMD67225.1 - 0.21 10.8 0.2 0.36 10.1 0.2 1.2 1 0 0 1 1 1 0 Frigida-like protein SUI1 PF01253.22 EMD67226.1 - 0.12 12.9 0.0 0.18 12.3 0.0 1.3 1 0 0 1 1 1 0 Translation initiation factor SUI1 Pkinase PF00069.25 EMD67227.1 - 1e-19 70.9 0.0 6.8e-13 48.6 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EMD67227.1 - 9.1e-11 41.5 0.0 2.2e-10 40.3 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Glyco_hydro_31 PF01055.26 EMD67228.1 - 1.2e-140 469.6 7.0 1.9e-140 469.0 7.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 EMD67228.1 - 5.7e-26 90.6 0.5 1.1e-24 86.5 0.2 2.8 2 0 0 2 2 2 1 Galactose mutarotase-like DUF5110 PF17137.4 EMD67228.1 - 5.5e-07 29.8 0.1 1.6e-06 28.2 0.1 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF5110) NDK PF00334.19 EMD67229.1 - 1.4e-54 183.7 0.0 1.6e-54 183.6 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase Amidase PF01425.21 EMD67231.1 - 2.8e-87 293.5 0.0 3.6e-87 293.2 0.0 1.1 1 0 0 1 1 1 1 Amidase p450 PF00067.22 EMD67232.1 - 9.8e-29 100.4 0.0 1.3e-28 100.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Vps54 PF07928.12 EMD67233.1 - 7.3e-48 162.4 1.1 1.7e-47 161.3 0.6 1.9 2 0 0 2 2 2 1 Vps54-like protein Vps54_N PF10475.9 EMD67233.1 - 0.001 18.4 0.2 0.001 18.4 0.2 2.4 3 0 0 3 3 3 1 Vacuolar-sorting protein 54, of GARP complex HAUS5 PF14817.6 EMD67233.1 - 0.034 12.9 0.0 0.11 11.2 0.0 1.8 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 5 Sec8_exocyst PF04048.14 EMD67233.1 - 0.047 13.6 0.8 5.1 7.0 0.0 3.2 3 1 1 4 4 4 0 Sec8 exocyst complex component specific domain Fez1 PF06818.15 EMD67233.1 - 5.7 7.3 6.8 9.8 6.6 0.5 2.6 2 1 0 2 2 2 0 Fez1 COS PF18568.1 EMD67234.1 - 0.02 14.8 0.0 0.029 14.3 0.0 1.3 1 0 0 1 1 1 0 TRIM C-terminal subgroup One Signature domain T3SS_basalb_I PF17001.5 EMD67234.1 - 0.063 13.9 0.1 0.079 13.6 0.1 1.1 1 0 0 1 1 1 0 Type III secretion basal body protein I, YscI, HrpB, PscI NACHT PF05729.12 EMD67235.1 - 0.00091 19.2 0.0 0.0013 18.7 0.0 1.2 1 0 0 1 1 1 1 NACHT domain Cadherin_2 PF08266.12 EMD67235.1 - 0.044 13.6 0.1 9.7 6.1 0.0 2.3 2 0 0 2 2 2 0 Cadherin-like Ank_2 PF12796.7 EMD67236.1 - 4e-20 72.2 0.0 9.7e-14 51.7 0.0 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 EMD67236.1 - 8.6e-16 57.6 0.1 1.5e-05 25.2 0.0 4.2 4 0 0 4 4 4 3 Ankyrin repeat Ank_3 PF13606.6 EMD67236.1 - 2e-13 49.2 0.2 0.00012 22.2 0.0 4.2 5 0 0 5 5 5 2 Ankyrin repeat Ank_4 PF13637.6 EMD67236.1 - 1.2e-12 48.1 0.0 3.8e-06 27.3 0.0 3.1 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EMD67236.1 - 4.3e-11 42.8 0.1 2e-05 24.8 0.0 3.5 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Terpene_synth_C PF03936.16 EMD67237.1 - 0.0013 18.2 0.1 0.0018 17.7 0.1 1.3 1 0 0 1 1 1 1 Terpene synthase family, metal binding domain PIN_6 PF17146.4 EMD67238.1 - 8.2e-30 103.2 0.2 8.2e-30 103.2 0.2 2.8 3 0 0 3 3 3 1 PIN domain of ribonuclease NOB1_Zn_bind PF08772.11 EMD67238.1 - 2e-27 95.1 2.9 2e-27 95.1 2.9 1.9 2 0 0 2 2 2 1 Nin one binding (NOB1) Zn-ribbon like zf-NADH-PPase PF09297.11 EMD67238.1 - 0.0048 16.5 1.1 0.0048 16.5 1.1 1.9 2 0 0 2 2 2 1 NADH pyrophosphatase zinc ribbon domain DUF2321 PF10083.9 EMD67238.1 - 0.043 13.5 0.3 0.043 13.5 0.3 2.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2321) RecR PF02132.15 EMD67238.1 - 0.17 11.5 2.5 0.29 10.7 1.8 1.8 1 1 1 2 2 2 0 RecR protein NAPRTase_C PF17956.1 EMD67238.1 - 4.6 7.7 9.4 13 6.3 8.6 2.2 2 0 0 2 2 2 0 Nicotinate phosphoribosyltransferase C-terminal domain DUF2939 PF11159.8 EMD67238.1 - 4.8 7.7 6.7 7.3e+02 0.7 6.7 2.9 1 1 0 1 1 1 0 Protein of unknown function (DUF2939) Tim17 PF02466.19 EMD67239.1 - 1.8e-41 141.0 4.2 1.8e-41 141.0 4.2 1.6 2 0 0 2 2 2 1 Tim17/Tim22/Tim23/Pmp24 family DUF4048 PF13257.6 EMD67240.1 - 1.2e-27 97.4 24.1 1.2e-27 97.4 24.1 4.5 2 2 1 3 3 3 1 Domain of unknown function (DUF4048) Pkinase PF00069.25 EMD67242.1 - 8.1e-67 225.4 0.0 1.2e-66 224.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD67242.1 - 1.7e-45 155.4 0.0 2.5e-45 154.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EMD67242.1 - 2e-06 26.9 0.0 2e-06 26.9 0.0 2.2 4 0 0 4 4 4 1 Fungal protein kinase Kinase-like PF14531.6 EMD67242.1 - 0.00031 20.1 0.0 0.011 15.0 0.0 2.3 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 EMD67242.1 - 0.0022 18.0 0.0 4 7.3 0.0 3.1 2 1 1 3 3 3 2 Phosphotransferase enzyme family Kdo PF06293.14 EMD67242.1 - 0.025 13.9 0.8 2.3 7.5 0.0 2.3 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family ABC1 PF03109.16 EMD67242.1 - 0.12 12.5 0.0 0.26 11.4 0.0 1.6 1 0 0 1 1 1 0 ABC1 family His_Phos_2 PF00328.22 EMD67243.1 - 1.3e-42 146.6 0.0 1.9e-42 146.0 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Xol-1_N PF09108.10 EMD67243.1 - 0.23 11.3 0.0 0.4 10.5 0.0 1.3 1 0 0 1 1 1 0 Switch protein XOL-1, N-terminal DUF2530 PF10745.9 EMD67244.1 - 0.33 11.2 2.9 1.1 9.5 2.9 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2530) adh_short PF00106.25 EMD67245.1 - 2.5e-42 144.6 0.0 3e-42 144.3 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD67245.1 - 4.8e-42 144.1 0.2 3e-39 135.0 0.0 2.1 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD67245.1 - 9.9e-14 51.6 0.1 1.5e-13 51.1 0.1 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EMD67245.1 - 0.0069 15.9 0.1 0.033 13.6 0.1 2.1 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family EspB PF05802.11 EMD67245.1 - 0.047 13.7 1.5 0.047 13.7 1.5 1.9 3 0 0 3 3 3 0 Enterobacterial EspB protein Dak1_2 PF13684.6 EMD67245.1 - 0.071 12.2 0.0 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 Dihydroxyacetone kinase family Pkinase_Tyr PF07714.17 EMD67246.1 - 1.3e-06 27.9 0.0 1.7e-06 27.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EMD67246.1 - 2.5e-06 27.1 0.0 3.3e-06 26.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain WD40 PF00400.32 EMD67248.1 - 2.1e-20 72.6 21.4 5.4e-05 23.9 0.0 7.6 7 1 0 7 7 7 4 WD domain, G-beta repeat Nup160 PF11715.8 EMD67248.1 - 0.00071 18.3 0.1 0.19 10.3 0.0 3.5 2 1 2 4 4 4 2 Nucleoporin Nup120/160 PQQ PF01011.21 EMD67248.1 - 0.0032 17.3 0.2 2.2 8.4 0.0 4.1 4 0 0 4 4 4 1 PQQ enzyme repeat DUF5046 PF16465.5 EMD67248.1 - 0.0054 16.2 0.9 0.17 11.3 0.1 2.7 2 1 1 3 3 3 1 Domain of unknown function (DUF5046) WD40_like PF17005.5 EMD67248.1 - 0.071 12.4 0.0 0.41 9.9 0.0 2.3 2 1 0 2 2 2 0 WD40-like domain PQQ_3 PF13570.6 EMD67248.1 - 2.5 8.7 13.2 7.1 7.3 0.1 4.9 5 1 0 5 5 5 0 PQQ-like domain Voldacs PF03517.13 EMD67249.1 - 1.1e-18 67.7 0.0 2.5e-18 66.5 0.0 1.6 1 0 0 1 1 1 1 Regulator of volume decrease after cellular swelling zinc_ribbon_9 PF14369.6 EMD67250.1 - 0.016 15.5 0.3 0.037 14.3 0.3 1.6 1 0 0 1 1 1 0 zinc-ribbon PepSY_TM PF03929.16 EMD67250.1 - 0.16 11.6 0.4 0.28 10.8 0.1 1.5 2 0 0 2 2 2 0 PepSY-associated TM region Podoplanin PF05808.11 EMD67250.1 - 0.17 12.0 2.1 0.21 11.7 0.8 1.9 1 1 0 1 1 1 0 Podoplanin Glyco_hydro_92 PF07971.12 EMD67251.1 - 3.5e-146 487.8 0.0 4.2e-146 487.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 Glyco_hydro_92N PF17678.1 EMD67251.1 - 3.3e-67 226.9 1.7 5.6e-67 226.1 1.7 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 N-terminal domain LIAS_N PF16881.5 EMD67252.1 - 0.13 12.7 0.1 0.22 12.0 0.1 1.4 1 0 0 1 1 1 0 N-terminal domain of lipoyl synthase of Radical_SAM family E1-E2_ATPase PF00122.20 EMD67255.1 - 1.3e-37 129.1 19.4 1.7e-31 109.2 0.0 4.0 3 1 1 4 4 4 2 E1-E2 ATPase Cation_ATPase_C PF00689.21 EMD67255.1 - 5e-27 94.8 1.1 5e-27 94.8 1.1 2.2 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 EMD67255.1 - 1.1e-19 71.6 1.0 4.5e-16 59.8 0.2 2.4 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EMD67255.1 - 1.7e-17 62.9 0.0 6.3e-17 61.0 0.0 2.0 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 EMD67255.1 - 9.9e-11 41.6 0.0 2e-10 40.6 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EMD67255.1 - 1.9e-06 27.8 1.0 7.8e-06 25.8 0.8 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF2463 PF09591.10 EMD67255.1 - 0.035 14.0 1.8 0.097 12.5 1.8 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2463) DUF1385 PF07136.11 EMD67255.1 - 0.041 13.2 0.1 0.041 13.2 0.1 2.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1385) HDA2-3 PF11496.8 EMD67256.1 - 3.4e-06 26.4 6.1 0.015 14.5 0.3 2.9 3 0 0 3 3 3 2 Class II histone deacetylase complex subunits 2 and 3 Chromo PF00385.24 EMD67256.1 - 0.00042 20.2 1.8 0.00098 19.0 1.8 1.7 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain PKcGMP_CC PF16808.5 EMD67256.1 - 1.1 9.2 5.5 14 5.7 0.2 3.9 3 0 0 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Peptidase_S46 PF10459.9 EMD67256.1 - 2.3 6.7 22.0 4.1 5.9 22.0 1.3 1 0 0 1 1 1 0 Peptidase S46 CTD_bind PF04818.13 EMD67257.1 - 0.0047 17.7 0.3 0.017 15.9 0.0 2.1 2 0 0 2 2 2 1 RNA polymerase II-binding domain. UPF0029 PF01205.19 EMD67258.1 - 3.9e-37 126.8 0.0 6.3e-37 126.1 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 RWD PF05773.22 EMD67258.1 - 1e-06 29.0 0.0 3.3e-06 27.4 0.0 1.8 1 1 0 1 1 1 1 RWD domain UQ_con PF00179.26 EMD67258.1 - 0.052 13.2 0.0 0.57 9.8 0.0 2.2 2 0 0 2 2 2 0 Ubiquitin-conjugating enzyme SPC25 PF06703.11 EMD67261.1 - 0.2 11.5 1.1 0.36 10.6 1.1 1.4 1 0 0 1 1 1 0 Microsomal signal peptidase 25 kDa subunit (SPC25) Syntaxin-6_N PF09177.11 EMD67262.1 - 7e-26 90.7 2.2 1.3e-25 89.8 0.3 2.2 1 1 1 2 2 2 1 Syntaxin 6, N-terminal HMMR_N PF15905.5 EMD67262.1 - 0.00099 18.7 1.4 0.00099 18.7 1.4 1.6 2 0 0 2 2 2 1 Hyaluronan mediated motility receptor N-terminal Laminin_II PF06009.12 EMD67262.1 - 0.0033 17.4 1.3 0.34 10.9 0.4 2.2 2 0 0 2 2 2 1 Laminin Domain II YtxH PF12732.7 EMD67262.1 - 0.004 17.7 1.9 1.2 9.7 0.3 3.0 2 1 0 2 2 2 1 YtxH-like protein Halogen_Hydrol PF10112.9 EMD67262.1 - 0.007 16.4 0.1 0.007 16.4 0.1 2.2 4 0 0 4 4 2 1 5-bromo-4-chloroindolyl phosphate hydrolysis protein Prominin PF05478.11 EMD67262.1 - 0.009 14.0 0.5 0.26 9.2 0.5 2.0 1 1 0 1 1 1 1 Prominin Mer2 PF09074.10 EMD67262.1 - 0.01 15.6 1.2 0.016 15.0 1.2 1.4 1 1 0 1 1 1 0 Mer2 Apolipoprotein PF01442.18 EMD67262.1 - 0.013 15.3 8.8 0.017 15.0 2.4 2.3 2 0 0 2 2 2 0 Apolipoprotein A1/A4/E domain Use1 PF09753.9 EMD67262.1 - 0.015 15.0 0.2 0.025 14.3 0.2 1.5 1 1 0 1 1 1 0 Membrane fusion protein Use1 XRCC4 PF06632.12 EMD67262.1 - 0.017 14.0 2.4 0.022 13.6 2.4 1.1 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 ApoLp-III PF07464.11 EMD67262.1 - 0.017 15.2 2.4 0.4 10.8 0.0 2.8 2 1 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) SNARE PF05739.19 EMD67262.1 - 0.022 14.8 0.2 0.022 14.8 0.2 2.6 3 0 0 3 3 2 0 SNARE domain DUF4795 PF16043.5 EMD67262.1 - 0.03 13.9 0.5 0.03 13.9 0.5 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4795) WXG100 PF06013.12 EMD67262.1 - 0.055 13.7 4.5 11 6.3 0.1 3.4 3 0 0 3 3 3 0 Proteins of 100 residues with WXG Atg14 PF10186.9 EMD67262.1 - 0.06 12.4 0.0 0.13 11.3 0.0 1.4 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 STAT_alpha PF01017.20 EMD67262.1 - 0.085 12.8 5.1 0.19 11.6 4.9 1.7 1 1 1 2 2 2 0 STAT protein, all-alpha domain Fez1 PF06818.15 EMD67262.1 - 0.11 12.9 4.8 0.17 12.3 4.8 1.3 1 0 0 1 1 1 0 Fez1 DUF3618 PF12277.8 EMD67262.1 - 0.12 12.6 6.1 16 5.8 0.0 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3618) KxDL PF10241.9 EMD67262.1 - 0.16 12.3 2.7 12 6.2 0.0 3.3 3 0 0 3 3 3 0 Uncharacterized conserved protein DUF1664 PF07889.12 EMD67262.1 - 0.16 12.0 6.0 1.9 8.5 1.4 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) RRF PF01765.19 EMD67262.1 - 0.18 11.7 3.6 3.4 7.6 0.3 2.9 2 1 1 3 3 3 0 Ribosome recycling factor DotU PF09850.9 EMD67262.1 - 0.26 11.0 6.3 1 9.1 0.1 3.3 2 2 1 3 3 3 0 Type VI secretion system protein DotU Wtap PF17098.5 EMD67262.1 - 0.27 11.1 5.8 1 9.3 0.3 3.0 3 0 0 3 3 3 0 WTAP/Mum2p family AKNA PF12443.8 EMD67262.1 - 0.31 11.7 5.9 0.58 10.8 0.1 2.5 2 1 1 3 3 2 0 AT-hook-containing transcription factor OmpH PF03938.14 EMD67262.1 - 0.34 11.2 10.9 36 4.7 10.9 2.5 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) GAS PF13851.6 EMD67262.1 - 0.36 10.2 5.2 0.57 9.5 2.0 2.2 2 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding Rx_N PF18052.1 EMD67262.1 - 0.39 11.0 7.2 0.56 10.5 2.1 2.5 1 1 0 2 2 2 0 Rx N-terminal domain DUF883 PF05957.13 EMD67262.1 - 0.43 11.2 7.8 2.8 8.6 0.2 3.2 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF883) DUF2205 PF10224.9 EMD67262.1 - 0.56 10.2 0.1 0.56 10.2 0.1 3.0 3 1 0 3 3 3 0 Short coiled-coil protein YojJ PF10372.9 EMD67262.1 - 1.2 9.3 3.4 13 6.0 0.1 3.4 3 1 1 4 4 4 0 Bacterial membrane-spanning protein N-terminus HIP1_clath_bdg PF16515.5 EMD67262.1 - 4 8.1 12.1 11 6.7 1.1 3.3 2 1 0 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Tropomyosin_1 PF12718.7 EMD67262.1 - 6.1 7.0 11.1 13 5.9 0.7 2.6 1 1 2 3 3 3 0 Tropomyosin like YabA PF06156.13 EMD67262.1 - 6.7 7.4 8.1 6.3 7.5 3.6 2.5 2 1 0 2 2 2 0 Initiation control protein YabA Methyltransf_32 PF13679.6 EMD67263.1 - 2.6e-21 76.3 3.7 4.8e-20 72.1 3.7 2.2 1 1 0 1 1 1 1 Methyltransferase domain Peptidase_S41 PF03572.18 EMD67264.1 - 6.5e-08 32.3 0.0 1.3e-07 31.3 0.0 1.5 1 0 0 1 1 1 1 Peptidase family S41 Asp PF00026.23 EMD67265.1 - 5.6e-09 35.9 0.0 6.9e-09 35.6 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_C PF14541.6 EMD67265.1 - 0.0056 16.5 0.0 0.011 15.6 0.0 1.4 1 0 0 1 1 1 1 Xylanase inhibitor C-terminal DUF4658 PF15555.6 EMD67267.1 - 0.87 9.7 2.6 1.2 9.3 0.6 1.8 1 1 0 2 2 2 0 Domain of unknown function (DUF4658) Glyco_hydro_72 PF03198.14 EMD67268.1 - 1.2e-120 402.6 2.3 1.4e-120 402.3 2.3 1.0 1 0 0 1 1 1 1 Glucanosyltransferase Glyco_hydro_2_C PF02836.17 EMD67268.1 - 2e-07 30.4 0.3 3.3e-07 29.7 0.3 1.3 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Cellulase PF00150.18 EMD67268.1 - 0.0031 17.0 4.2 0.012 15.0 4.1 1.9 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) SGS PF05002.15 EMD67269.1 - 4.7e-29 100.3 0.7 9.6e-29 99.3 0.7 1.6 1 0 0 1 1 1 1 SGS domain CS PF04969.16 EMD67269.1 - 2.8e-16 60.3 0.1 5.9e-16 59.3 0.1 1.6 1 0 0 1 1 1 1 CS domain TPR_1 PF00515.28 EMD67269.1 - 6.8e-09 35.2 0.7 0.00011 21.8 0.0 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 EMD67269.1 - 2e-08 33.7 1.0 0.031 14.4 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 EMD67269.1 - 1.7e-06 28.6 1.5 0.011 16.4 0.0 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 EMD67269.1 - 0.0094 16.2 0.7 6.5 7.1 0.2 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 EMD67269.1 - 0.01 15.5 0.6 0.029 14.1 0.1 2.0 2 0 0 2 2 2 0 TPR repeat SRP_TPR_like PF17004.5 EMD67269.1 - 0.012 15.6 0.2 0.021 14.9 0.2 1.4 1 0 0 1 1 1 0 Putative TPR-like repeat TPR_8 PF13181.6 EMD67269.1 - 0.024 14.8 0.1 0.46 10.8 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.6 EMD67269.1 - 0.042 14.4 0.1 4.9 7.7 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 EMD67269.1 - 0.051 14.4 0.1 4.1 8.5 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF3856 PF12968.7 EMD67269.1 - 0.055 13.5 0.1 0.17 12.0 0.1 1.8 1 1 0 1 1 1 0 Domain of Unknown Function (DUF3856) CppA_N PF14506.6 EMD67269.1 - 0.1 12.7 0.0 0.55 10.3 0.0 2.1 1 1 1 2 2 2 0 CppA N-terminal TPR_6 PF13174.6 EMD67269.1 - 0.16 12.7 0.2 2.7 8.8 0.2 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF1996 PF09362.10 EMD67273.1 - 8e-86 287.8 0.3 1.1e-85 287.4 0.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1996) GDPD_2 PF13653.6 EMD67275.1 - 0.0081 16.6 0.8 0.0081 16.6 0.8 2.1 2 0 0 2 2 2 1 Glycerophosphoryl diester phosphodiesterase family PQ-loop PF04193.14 EMD67276.1 - 1.4e-39 133.7 15.5 1.5e-20 72.7 4.6 2.9 3 0 0 3 3 3 2 PQ loop repeat DUF962 PF06127.11 EMD67277.1 - 9.4e-25 86.5 0.4 1.3e-24 86.0 0.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF962) Sugar_tr PF00083.24 EMD67278.1 - 5.1e-85 286.0 19.1 7.2e-85 285.5 19.1 1.3 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD67278.1 - 3.1e-14 52.7 40.4 3.2e-09 36.2 16.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily UAA PF08449.11 EMD67278.1 - 0.0023 17.2 0.1 0.0048 16.1 0.1 1.4 1 0 0 1 1 1 1 UAA transporter family Gtr1_RagA PF04670.12 EMD67279.1 - 5.7e-94 313.8 0.1 7.1e-94 313.5 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Roc PF08477.13 EMD67279.1 - 3.4e-08 33.7 0.0 7.7e-08 32.6 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EMD67279.1 - 6.7e-08 32.3 0.7 1.3e-07 31.4 0.1 1.8 2 0 0 2 2 2 1 Ras family Arf PF00025.21 EMD67279.1 - 3.5e-07 29.8 0.0 6.4e-07 29.0 0.0 1.5 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EMD67279.1 - 1.4e-06 28.4 0.0 3.4e-06 27.1 0.0 1.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase DUF815 PF05673.13 EMD67279.1 - 0.0024 17.1 0.1 0.004 16.4 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) GTP_EFTU PF00009.27 EMD67279.1 - 0.0035 16.9 0.0 0.0092 15.5 0.0 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EMD67279.1 - 0.018 15.0 0.1 0.16 11.8 0.1 2.2 2 0 0 2 2 2 0 RsgA GTPase ABC_tran PF00005.27 EMD67279.1 - 0.022 15.3 0.0 0.056 13.9 0.0 1.6 1 0 0 1 1 1 0 ABC transporter AAA_29 PF13555.6 EMD67279.1 - 0.042 13.6 0.3 0.15 11.8 0.1 2.0 2 0 0 2 2 2 0 P-loop containing region of AAA domain G-alpha PF00503.20 EMD67279.1 - 0.15 11.2 5.2 3.2 6.8 0.0 2.9 1 1 1 3 3 3 0 G-protein alpha subunit DUF1688 PF07958.11 EMD67280.1 - 5e-185 615.2 0.0 5.7e-185 615.0 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1688) TPR_1 PF00515.28 EMD67281.1 - 5.2e-05 22.9 0.5 1.2 9.1 0.0 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 EMD67281.1 - 0.00012 22.0 0.6 21 5.5 0.0 4.2 4 0 0 4 4 4 3 Tetratricopeptide repeat DnaJ PF00226.31 EMD67281.1 - 0.11 12.7 0.1 0.11 12.7 0.1 2.3 3 0 0 3 3 3 0 DnaJ domain Ceramidase_alk PF04734.13 EMD67281.1 - 0.12 10.9 0.5 0.2 10.3 0.5 1.2 1 0 0 1 1 1 0 Neutral/alkaline non-lysosomal ceramidase, N-terminal Fungal_trans PF04082.18 EMD67283.1 - 7.7e-09 35.0 0.0 3.9e-08 32.6 0.0 2.2 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD67283.1 - 7.7e-05 22.7 10.7 0.00015 21.8 10.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Rbx_binding PF18113.1 EMD67284.1 - 0.094 12.5 0.0 0.16 11.8 0.0 1.3 1 0 0 1 1 1 0 Rubredoxin binding C-terminal domain PBP_N PF17093.5 EMD67284.1 - 0.49 10.6 3.9 0.8 10.0 3.3 1.9 1 1 1 2 2 2 0 Penicillin-binding protein N-terminus WW PF00397.26 EMD67285.1 - 1.2e-08 34.9 6.4 2.6e-08 33.8 6.4 1.6 1 0 0 1 1 1 1 WW domain WRW PF10206.9 EMD67285.1 - 0.038 14.4 0.2 0.12 12.8 0.2 1.8 1 0 0 1 1 1 0 Mitochondrial F1F0-ATP synthase, subunit f Ank_2 PF12796.7 EMD67286.1 - 1.6e-25 89.5 1.1 4.9e-17 62.3 0.3 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMD67286.1 - 4.3e-18 65.4 0.7 1e-13 51.4 0.1 2.2 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 EMD67286.1 - 8.3e-17 60.8 1.0 6.9e-09 35.8 0.1 3.2 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 EMD67286.1 - 1.6e-13 49.5 0.1 2.8e-06 27.2 0.0 3.2 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 EMD67286.1 - 1.9e-13 50.3 2.6 3.9e-08 33.4 0.2 2.9 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Tudor_3 PF18115.1 EMD67288.1 - 1e-16 60.5 0.1 2.6e-16 59.2 0.1 1.7 1 0 0 1 1 1 1 DNA repair protein Crb2 Tudor domain Rad9_Rad53_bind PF08605.10 EMD67288.1 - 1.8e-13 50.8 0.0 3.4e-13 49.9 0.0 1.4 1 0 0 1 1 1 1 Fungal Rad9-like Rad53-binding BRCT PF00533.26 EMD67288.1 - 3.4e-08 33.7 0.0 9.7e-08 32.3 0.0 1.8 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EMD67288.1 - 0.001 19.5 0.0 0.0031 17.9 0.0 1.9 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain Sdh_cyt PF01127.22 EMD67289.1 - 2.4e-24 85.7 3.8 2.9e-24 85.4 3.8 1.1 1 0 0 1 1 1 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit WD40 PF00400.32 EMD67290.1 - 1.6e-09 38.2 2.2 0.0041 17.9 0.0 4.6 5 0 0 5 5 5 3 WD domain, G-beta repeat Ge1_WD40 PF16529.5 EMD67290.1 - 0.0044 16.0 0.1 1 8.2 0.0 2.4 2 0 0 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nucleoporin_N PF08801.11 EMD67290.1 - 0.035 12.9 0.0 1.5 7.5 0.0 2.5 2 1 1 3 3 3 0 Nup133 N terminal like SQHop_cyclase_C PF13243.6 EMD67291.1 - 9.8e-50 169.4 1.2 3e-47 161.3 0.9 2.5 2 1 1 3 3 3 2 Squalene-hopene cyclase C-terminal domain SQHop_cyclase_N PF13249.6 EMD67291.1 - 4e-42 144.3 5.9 1.1e-34 119.9 0.2 4.4 3 2 2 5 5 5 3 Squalene-hopene cyclase N-terminal domain Prenyltrans PF00432.21 EMD67291.1 - 4.7e-27 93.4 5.0 2.2e-08 33.7 0.0 4.6 4 0 0 4 4 4 3 Prenyltransferase and squalene oxidase repeat TED_complement PF07678.14 EMD67291.1 - 0.0029 16.7 0.1 0.037 13.1 0.1 2.7 1 1 2 3 3 3 1 A-macroglobulin TED domain Pec_lyase PF09492.10 EMD67291.1 - 0.0041 16.5 0.2 6.4 6.0 0.0 4.2 3 2 1 4 4 4 1 Pectic acid lyase DUF1295 PF06966.12 EMD67294.1 - 4.4e-12 46.0 0.0 5.6e-12 45.7 0.0 1.2 1 1 0 1 1 1 1 Protein of unknown function (DUF1295) Steroid_dh PF02544.16 EMD67294.1 - 0.0098 15.9 0.0 0.011 15.7 0.0 1.1 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase DNA_ligase_A_M PF01068.21 EMD67295.1 - 7.4e-29 100.9 0.0 1.4e-28 100.0 0.0 1.4 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 EMD67295.1 - 1.8e-19 70.7 0.0 3.7e-19 69.7 0.0 1.5 1 0 0 1 1 1 1 DNA ligase N terminus RNA_ligase PF09414.10 EMD67295.1 - 4.1e-06 27.2 0.0 4.2e-05 23.9 0.0 2.1 2 0 0 2 2 2 1 RNA ligase DUF4941 PF16299.5 EMD67295.1 - 0.23 10.7 0.0 0.39 10.0 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4941) DUF5597 PF18120.1 EMD67296.1 - 3.4e-24 85.4 0.0 5.8e-24 84.7 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF5597) Glyco_hydro_42 PF02449.15 EMD67296.1 - 1.6e-12 47.5 0.0 2.3e-12 46.9 0.0 1.2 1 0 0 1 1 1 1 Beta-galactosidase Glyco_hydro_35 PF01301.19 EMD67296.1 - 6.5e-08 32.6 0.0 5.9e-07 29.4 0.0 2.0 1 1 0 1 1 1 1 Glycosyl hydrolases family 35 SPC22 PF04573.12 EMD67297.1 - 1.3e-39 135.4 0.1 6.8e-29 100.5 0.0 2.1 2 0 0 2 2 2 2 Signal peptidase subunit Pyr_redox_2 PF07992.14 EMD67298.1 - 3.8e-06 26.4 0.0 5.7e-05 22.5 0.0 2.3 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EMD67298.1 - 0.00016 21.1 0.1 0.0067 15.7 0.0 3.0 3 1 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EMD67298.1 - 0.00028 21.1 0.0 0.0045 17.2 0.1 2.7 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Shikimate_DH PF01488.20 EMD67298.1 - 0.0087 16.1 0.0 0.14 12.2 0.0 2.2 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase K_oxygenase PF13434.6 EMD67298.1 - 0.015 14.5 0.0 0.05 12.7 0.0 1.8 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 EMD67298.1 - 0.016 15.2 0.1 0.81 9.7 0.1 3.0 3 0 0 3 3 3 0 FAD-NAD(P)-binding 2-Hacid_dh_C PF02826.19 EMD67298.1 - 0.044 13.1 0.0 0.082 12.3 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Ribonucleas_3_3 PF14622.6 EMD67299.1 - 3.4e-15 56.3 0.0 4.6e-15 55.9 0.0 1.2 1 0 0 1 1 1 1 Ribonuclease-III-like Ribonuclease_3 PF00636.26 EMD67299.1 - 2.6e-09 37.6 0.0 7.2e-09 36.2 0.0 1.7 1 1 0 1 1 1 1 Ribonuclease III domain ssDNA_DBD PF18333.1 EMD67300.1 - 0.015 15.4 1.5 0.017 15.2 1.5 1.1 1 0 0 1 1 1 0 Non-canonical single-stranded DNA-binding domain ADH_N PF08240.12 EMD67301.1 - 0.0017 18.2 0.0 0.0089 15.9 0.0 1.9 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain ParA PF10609.9 EMD67302.1 - 9.3e-87 290.5 0.0 1.4e-84 283.4 0.0 2.1 1 1 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 EMD67302.1 - 1.7e-11 44.3 0.0 1.1e-10 41.6 0.0 2.0 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MipZ PF09140.11 EMD67302.1 - 1.9e-06 27.4 0.0 5.8e-06 25.8 0.0 1.8 1 1 1 2 2 2 1 ATPase MipZ ArsA_ATPase PF02374.15 EMD67302.1 - 4.2e-06 26.2 0.2 8e-05 22.0 0.1 2.2 2 0 0 2 2 2 1 Anion-transporting ATPase AAA_31 PF13614.6 EMD67302.1 - 8.1e-05 22.6 0.3 0.00037 20.5 0.3 1.9 1 1 0 1 1 1 1 AAA domain AAA_26 PF13500.6 EMD67302.1 - 0.00077 19.3 0.9 0.064 13.1 0.0 2.2 2 0 0 2 2 2 1 AAA domain MeaB PF03308.16 EMD67302.1 - 0.0022 17.0 0.1 0.0033 16.4 0.1 1.2 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_25 PF13481.6 EMD67302.1 - 0.005 16.4 0.1 0.01 15.5 0.1 1.4 1 0 0 1 1 1 1 AAA domain CBP_BcsQ PF06564.12 EMD67302.1 - 0.015 14.7 0.2 0.045 13.2 0.1 1.7 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsQ APS_kinase PF01583.20 EMD67302.1 - 0.056 13.3 0.1 0.093 12.6 0.1 1.3 1 0 0 1 1 1 0 Adenylylsulphate kinase RsgA_GTPase PF03193.16 EMD67302.1 - 0.12 12.3 1.6 0.19 11.6 0.8 1.7 2 0 0 2 2 2 0 RsgA GTPase Zeta_toxin PF06414.12 EMD67302.1 - 0.13 11.6 0.0 0.23 10.7 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin CLP1_P PF16575.5 EMD67302.1 - 0.17 11.7 0.0 0.35 10.6 0.0 1.5 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop Abi_HHR PF07815.14 EMD67303.1 - 0.0002 21.5 2.0 0.072 13.2 1.1 3.1 3 0 0 3 3 3 2 Abl-interactor HHR Aldo_ket_red PF00248.21 EMD67304.1 - 1.5e-51 175.4 0.0 1.7e-51 175.2 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family LCCL PF03815.19 EMD67305.1 - 5.5e-20 71.3 0.0 1.2e-19 70.3 0.0 1.6 1 0 0 1 1 1 1 LCCL domain Aminotran_1_2 PF00155.21 EMD67306.1 - 9e-07 28.4 0.0 1.1e-05 24.8 0.0 2.1 1 1 0 1 1 1 1 Aminotransferase class I and II DUF1115 PF06544.12 EMD67307.1 - 9.7e-11 42.0 0.0 1.3e-10 41.5 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1115) DUF3237 PF11578.8 EMD67308.1 - 1e-25 90.3 0.0 4.2e-24 85.1 0.0 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF3237) MMS1_N PF10433.9 EMD67308.1 - 0.051 12.2 0.0 0.06 12.0 0.0 1.0 1 0 0 1 1 1 0 Mono-functional DNA-alkylating methyl methanesulfonate N-term Pkinase PF00069.25 EMD67309.1 - 2.3e-11 43.5 0.0 0.00016 21.1 0.0 2.9 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EMD67309.1 - 1.3e-07 31.2 0.0 0.014 14.7 0.0 2.9 2 1 0 2 2 2 2 Protein tyrosine kinase FAT PF02259.23 EMD67310.1 - 2.5e-73 247.3 7.1 5.6e-73 246.1 7.1 1.7 1 0 0 1 1 1 1 FAT domain PI3_PI4_kinase PF00454.27 EMD67310.1 - 3.9e-35 121.9 0.0 1.1e-34 120.4 0.0 1.9 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.20 EMD67310.1 - 0.00021 21.0 0.1 0.00074 19.3 0.1 2.1 1 0 0 1 1 1 1 FATC domain TPR_8 PF13181.6 EMD67310.1 - 0.18 12.1 2.3 0.79 10.1 0.1 3.2 2 0 0 2 2 2 0 Tetratricopeptide repeat UreF PF01730.16 EMD67310.1 - 2 9.0 4.6 5.8 7.5 0.0 3.5 4 0 0 4 4 4 0 UreF Rtf2 PF04641.12 EMD67310.1 - 2.7 7.3 5.8 5.4 6.3 5.8 1.4 1 0 0 1 1 1 0 Rtf2 RING-finger COX5A PF02284.16 EMD67311.1 - 5.3e-42 142.0 0.1 7.2e-42 141.6 0.1 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Va Scm3 PF10384.9 EMD67311.1 - 0.079 12.7 0.2 0.13 12.0 0.2 1.3 1 0 0 1 1 1 0 Centromere protein Scm3 Tau95_N PF17682.1 EMD67312.1 - 7.4e-34 116.7 0.0 2.2e-33 115.2 0.0 1.8 1 0 0 1 1 1 1 Tau95 Triple barrel domain Tau95 PF09734.9 EMD67312.1 - 1.6e-32 113.3 2.0 2.6e-32 112.5 0.1 2.1 2 0 0 2 2 2 1 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain Adeno_PV PF03910.13 EMD67312.1 - 0.058 12.1 0.1 0.099 11.3 0.1 1.3 1 0 0 1 1 1 0 Adenovirus minor core protein PV Stealth_CR3 PF17102.5 EMD67312.1 - 0.12 12.3 0.2 0.26 11.2 0.2 1.5 1 0 0 1 1 1 0 Stealth protein CR3, conserved region 3 B56 PF01603.20 EMD67313.1 - 3.8e-193 642.1 5.7 4.5e-193 641.9 5.7 1.0 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) Sec7_N PF12783.7 EMD67313.1 - 0.00045 20.2 1.5 0.29 11.1 0.0 2.4 2 0 0 2 2 2 2 Guanine nucleotide exchange factor in Golgi transport N-terminal SOG2 PF10428.9 EMD67313.1 - 6.1 5.9 9.5 20 4.2 0.0 2.2 2 0 0 2 2 2 0 RAM signalling pathway protein ELO PF01151.18 EMD67314.1 - 9.1e-61 205.5 18.4 1.1e-60 205.3 18.4 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family Kelch_5 PF13854.6 EMD67314.1 - 0.061 13.3 0.0 0.16 12.0 0.0 1.8 1 0 0 1 1 1 0 Kelch motif Opi1 PF08618.10 EMD67315.1 - 3.9e-35 121.9 17.5 9.6e-23 81.1 10.8 3.8 1 1 2 3 3 3 3 Transcription factor Opi1 TPR_12 PF13424.6 EMD67316.1 - 3.7e-21 75.2 0.1 2.1e-12 47.1 0.0 2.8 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 EMD67316.1 - 4.7e-13 48.5 0.0 8.9e-07 28.6 0.0 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 EMD67316.1 - 1.5e-06 27.8 0.0 0.0053 16.7 0.0 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.28 EMD67316.1 - 3.7e-05 23.4 0.0 0.01 15.6 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat NB-ARC PF00931.22 EMD67316.1 - 7.5e-05 22.0 0.0 0.0008 18.7 0.0 2.3 1 1 0 1 1 1 1 NB-ARC domain TPR_19 PF14559.6 EMD67316.1 - 0.0014 19.1 0.0 0.0044 17.5 0.0 1.9 2 0 0 2 2 2 1 Tetratricopeptide repeat AAA_22 PF13401.6 EMD67316.1 - 0.0014 18.9 0.0 0.0057 16.9 0.0 2.1 1 1 0 1 1 1 1 AAA domain TPR_2 PF07719.17 EMD67316.1 - 0.0015 18.5 0.0 1 9.6 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat AAA_16 PF13191.6 EMD67316.1 - 0.017 15.6 0.1 0.057 13.8 0.1 1.9 1 1 0 1 1 1 0 AAA ATPase domain PGAP1 PF07819.13 EMD67316.1 - 0.067 12.9 0.0 0.4 10.4 0.0 2.1 2 0 0 2 2 2 0 PGAP1-like protein DUF3226 PF11536.8 EMD67316.1 - 0.091 12.4 0.1 2.6 7.7 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3226) TPR_8 PF13181.6 EMD67316.1 - 0.1 12.9 0.1 1.2 9.5 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_17 PF13431.6 EMD67316.1 - 0.13 12.7 0.1 3.7 8.2 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat ABC2_membrane PF01061.24 EMD67319.1 - 1.1e-79 266.7 54.6 1.4e-40 139.0 16.7 2.6 3 0 0 3 3 2 2 ABC-2 type transporter ABC_tran PF00005.27 EMD67319.1 - 6.4e-37 127.1 0.0 3.8e-17 63.1 0.0 2.5 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.12 EMD67319.1 - 2.6e-28 97.8 7.3 2.4e-23 81.8 0.0 3.5 3 0 0 3 3 2 2 CDR ABC transporter ABC_trans_N PF14510.6 EMD67319.1 - 1.3e-16 60.9 0.2 4.4e-16 59.3 0.2 2.0 1 0 0 1 1 1 1 ABC-transporter N-terminal ABC2_membrane_3 PF12698.7 EMD67319.1 - 1.1e-09 38.0 32.4 3.5e-07 29.7 13.4 3.0 2 1 1 3 3 3 2 ABC-2 family transporter protein AAA_21 PF13304.6 EMD67319.1 - 7.2e-06 26.0 0.0 0.13 12.0 0.0 2.9 3 0 0 3 3 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_33 PF13671.6 EMD67319.1 - 3.4e-05 24.0 0.0 0.067 13.4 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EMD67319.1 - 6.1e-05 23.5 0.4 0.034 14.5 0.2 3.1 3 1 0 3 3 3 1 AAA ATPase domain AAA_18 PF13238.6 EMD67319.1 - 0.0001 22.8 0.0 0.09 13.3 0.0 3.0 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 EMD67319.1 - 0.00011 21.9 0.3 0.012 15.3 0.1 2.8 2 0 0 2 2 2 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EMD67319.1 - 0.00028 20.8 0.0 0.0019 18.2 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase AAA_25 PF13481.6 EMD67319.1 - 0.00036 20.2 0.7 0.0056 16.3 0.1 2.6 2 0 0 2 2 2 1 AAA domain SMC_N PF02463.19 EMD67319.1 - 0.0031 17.0 0.0 1.1 8.6 0.0 3.3 3 0 0 3 3 3 1 RecF/RecN/SMC N terminal domain cobW PF02492.19 EMD67319.1 - 0.0096 15.5 0.5 0.23 11.1 0.5 2.3 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_22 PF13401.6 EMD67319.1 - 0.014 15.6 0.1 0.31 11.3 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 EMD67319.1 - 0.021 14.5 0.2 1.1 8.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 EMD67319.1 - 0.033 14.1 0.5 5.8 6.8 0.2 2.5 2 0 0 2 2 2 0 NACHT domain PduV-EutP PF10662.9 EMD67319.1 - 0.033 13.9 1.1 5.8 6.7 0.1 2.6 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_28 PF13521.6 EMD67319.1 - 0.042 14.1 0.6 0.15 12.3 0.1 2.1 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.6 EMD67319.1 - 0.062 13.7 0.5 4.3 7.8 0.0 2.6 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 EMD67319.1 - 0.14 12.2 0.3 2.4 8.3 0.0 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase RNA_helicase PF00910.22 EMD67319.1 - 0.24 11.8 0.4 69 3.9 0.0 3.3 3 0 0 3 3 3 0 RNA helicase AAA_23 PF13476.6 EMD67319.1 - 0.61 10.6 4.3 0.47 10.9 0.1 2.9 4 0 0 4 4 4 0 AAA domain TAF6_C PF07571.13 EMD67321.1 - 1.3e-23 83.1 0.1 3.7e-23 81.7 0.0 1.9 2 0 0 2 2 2 1 TAF6 C-terminal HEAT repeat domain TAF PF02969.17 EMD67321.1 - 1.6e-23 82.6 0.2 8.9e-23 80.3 0.1 2.1 2 0 0 2 2 2 1 TATA box binding protein associated factor (TAF) Histone PF00125.24 EMD67321.1 - 0.0058 17.0 0.1 0.011 16.0 0.1 1.5 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TFIID-31kDa PF02291.15 EMD67321.1 - 0.026 14.6 0.1 0.072 13.2 0.1 1.7 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 EMD67321.1 - 0.066 13.2 0.0 0.29 11.2 0.0 2.0 2 0 0 2 2 2 0 Bromodomain associated DUF1778 PF08681.11 EMD67321.1 - 0.11 12.5 0.3 14 5.7 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1778) CBFD_NFYB_HMF PF00808.23 EMD67321.1 - 0.11 12.7 0.0 0.32 11.3 0.0 1.8 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Gemini_mov PF01708.16 EMD67322.1 - 0.074 12.8 0.3 0.092 12.5 0.3 1.1 1 0 0 1 1 1 0 Geminivirus putative movement protein PRIMA1 PF16101.5 EMD67322.1 - 0.36 10.9 4.9 0.37 10.8 4.9 1.2 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 CAP_N PF01213.19 EMD67322.1 - 1.5 8.2 3.6 1.5 8.3 3.6 1.1 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal DEAD PF00270.29 EMD67323.1 - 8.3e-18 64.8 0.0 1.7e-17 63.8 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 EMD67323.1 - 8.8e-13 48.6 0.5 3.8e-12 46.5 0.0 2.3 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EMD67323.1 - 1.2e-06 28.8 0.0 3.5e-06 27.3 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain PhoH PF02562.16 EMD67323.1 - 0.15 11.5 0.0 0.72 9.3 0.0 2.0 2 0 0 2 2 2 0 PhoH-like protein Mito_carr PF00153.27 EMD67324.1 - 1.6e-13 50.4 0.7 0.00087 19.2 0.0 5.0 4 1 0 4 4 4 4 Mitochondrial carrier protein Fer2 PF00111.27 EMD67325.1 - 4.2e-15 55.5 0.8 5.7e-15 55.0 0.8 1.2 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Rrp15p PF07890.12 EMD67326.1 - 5.7e-37 127.1 8.9 5.7e-37 127.1 8.9 3.4 2 1 0 2 2 2 1 Rrp15p DUF3246 PF11596.8 EMD67326.1 - 0.0015 18.1 2.6 0.0023 17.4 2.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3246) SRP54 PF00448.22 EMD67327.1 - 1.5e-75 253.2 1.4 4e-75 251.8 1.3 1.7 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.19 EMD67327.1 - 6.8e-32 110.0 4.8 6.8e-32 110.0 4.8 4.0 3 1 2 5 5 4 1 Signal peptide binding domain SRP54_N PF02881.19 EMD67327.1 - 1.6e-20 73.1 0.7 4.3e-20 71.7 0.7 1.8 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain AAA_33 PF13671.6 EMD67327.1 - 2.2e-06 27.9 0.1 7.4e-06 26.2 0.1 2.0 2 0 0 2 2 1 1 AAA domain cobW PF02492.19 EMD67327.1 - 2.7e-06 27.1 0.3 9.4e-06 25.3 0.3 1.9 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_17 PF13207.6 EMD67327.1 - 0.00076 19.9 1.2 0.0016 18.9 0.1 2.2 2 0 0 2 2 1 1 AAA domain AAA_22 PF13401.6 EMD67327.1 - 0.0013 19.0 0.1 0.0037 17.5 0.1 1.8 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EMD67327.1 - 0.0023 18.3 0.0 0.0044 17.4 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain Zeta_toxin PF06414.12 EMD67327.1 - 0.0026 17.1 0.0 0.0063 15.8 0.0 1.6 1 0 0 1 1 1 1 Zeta toxin Thymidylate_kin PF02223.17 EMD67327.1 - 0.0028 17.4 0.3 0.016 14.9 0.0 2.1 2 0 0 2 2 2 1 Thymidylate kinase APS_kinase PF01583.20 EMD67327.1 - 0.0039 17.1 0.0 0.0082 16.0 0.0 1.5 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_30 PF13604.6 EMD67327.1 - 0.0041 16.9 0.2 0.0041 16.9 0.2 2.3 3 1 0 3 3 2 1 AAA domain CbiA PF01656.23 EMD67327.1 - 0.0044 17.1 0.0 0.01 15.9 0.0 1.7 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MobB PF03205.14 EMD67327.1 - 0.011 15.6 0.1 0.042 13.8 0.0 2.0 1 1 1 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_18 PF13238.6 EMD67327.1 - 0.021 15.3 0.0 0.047 14.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain DUF3052 PF11253.8 EMD67327.1 - 0.043 13.8 0.1 0.14 12.1 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3052) 6PF2K PF01591.18 EMD67327.1 - 0.047 13.0 0.0 0.076 12.3 0.0 1.3 1 0 0 1 1 1 0 6-phosphofructo-2-kinase MMR_HSR1 PF01926.23 EMD67327.1 - 0.05 13.7 0.1 0.19 11.8 0.1 2.0 1 1 0 1 1 1 0 50S ribosome-binding GTPase ATP_bind_1 PF03029.17 EMD67327.1 - 0.053 13.3 2.8 0.1 12.4 0.0 2.6 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein TrwB_AAD_bind PF10412.9 EMD67327.1 - 0.055 12.4 0.0 0.11 11.4 0.0 1.4 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain AAA_28 PF13521.6 EMD67327.1 - 0.056 13.7 0.0 0.1 12.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain ResIII PF04851.15 EMD67327.1 - 0.059 13.4 0.1 0.18 11.8 0.1 1.7 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_19 PF13245.6 EMD67327.1 - 0.06 13.7 0.1 0.06 13.7 0.1 2.0 2 0 0 2 2 1 0 AAA domain ApbA PF02558.16 EMD67327.1 - 0.062 12.9 1.0 8.1 6.1 0.2 2.8 1 1 1 2 2 2 0 Ketopantoate reductase PanE/ApbA AAA_31 PF13614.6 EMD67327.1 - 0.099 12.5 0.0 0.24 11.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain SRPRB PF09439.10 EMD67327.1 - 0.19 11.1 2.1 5.6 6.3 0.1 3.2 3 1 0 4 4 4 0 Signal recognition particle receptor beta subunit FMO-like PF00743.19 EMD67328.1 - 5.6e-36 124.1 0.0 3.1e-21 75.4 0.0 3.0 3 0 0 3 3 3 3 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EMD67328.1 - 6.4e-12 45.3 0.0 7.4e-08 32.0 0.0 3.2 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EMD67328.1 - 6.4e-10 38.7 0.3 3.8e-07 29.6 0.0 3.0 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 EMD67328.1 - 2e-08 34.4 0.0 2e-07 31.2 0.0 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EMD67328.1 - 2.8e-08 33.4 0.0 3.5e-07 29.8 0.0 2.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EMD67328.1 - 2.1e-07 31.1 0.0 6.1e-06 26.3 0.0 3.0 2 1 0 2 2 2 1 FAD-NAD(P)-binding Thi4 PF01946.17 EMD67328.1 - 5e-06 25.9 0.1 0.00027 20.2 0.0 2.2 2 0 0 2 2 2 1 Thi4 family DAO PF01266.24 EMD67328.1 - 0.00022 20.9 0.1 0.03 13.9 0.1 3.0 3 0 0 3 3 3 1 FAD dependent oxidoreductase HI0933_like PF03486.14 EMD67328.1 - 0.0043 15.8 0.0 0.057 12.1 0.0 2.2 2 0 0 2 2 2 1 HI0933-like protein FAD_oxidored PF12831.7 EMD67328.1 - 0.14 11.5 0.0 0.21 10.9 0.0 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase Glu_dehyd_C PF16912.5 EMD67328.1 - 0.2 11.1 0.0 0.56 9.7 0.0 1.7 2 0 0 2 2 2 0 Glucose dehydrogenase C-terminus NMT1 PF09084.11 EMD67329.1 - 1.6e-07 31.5 0.0 3e-07 30.6 0.0 1.4 1 0 0 1 1 1 1 NMT1/THI5 like SBP_bac_3 PF00497.20 EMD67329.1 - 4.2e-05 23.1 0.0 9e-05 22.0 0.0 1.6 1 1 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 SBP_bac_11 PF13531.6 EMD67329.1 - 0.0017 18.1 0.0 0.0071 16.1 0.0 2.0 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 EMD67329.1 - 0.014 15.4 0.0 0.046 13.7 0.0 1.8 2 0 0 2 2 2 0 Bacterial extracellular solute-binding protein tRNA_NucTran2_2 PF13735.6 EMD67329.1 - 0.1 12.6 0.0 0.17 11.8 0.0 1.3 1 0 0 1 1 1 0 tRNA nucleotidyltransferase domain 2 putative ApoC-I PF04691.12 EMD67329.1 - 0.15 12.0 2.4 0.63 10.0 1.2 2.2 1 1 1 2 2 2 0 Apolipoprotein C-I (ApoC-1) Transferase PF02458.15 EMD67330.1 - 3.3e-17 62.3 0.0 6.7e-11 41.5 0.0 3.3 3 0 0 3 3 3 3 Transferase family zf-C2H2 PF00096.26 EMD67331.1 - 1.6e-05 25.1 26.0 0.007 16.8 1.7 5.0 4 0 0 4 4 4 2 Zinc finger, C2H2 type zf-Di19 PF05605.12 EMD67331.1 - 2.5e-05 24.5 12.0 0.29 11.4 3.2 3.8 3 0 0 3 3 3 3 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_jaz PF12171.8 EMD67331.1 - 0.00062 20.0 13.3 0.15 12.4 1.0 4.6 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.6 EMD67331.1 - 0.00081 19.7 0.5 0.00081 19.7 0.5 6.3 7 0 0 7 7 7 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMD67331.1 - 0.0014 19.3 31.3 0.0061 17.3 4.1 6.1 6 0 0 6 6 6 2 C2H2-type zinc finger C1_4 PF07975.12 EMD67331.1 - 0.28 11.5 10.7 0.021 15.0 4.0 2.4 2 0 0 2 2 2 0 TFIIH C1-like domain zf-C6H2 PF15801.5 EMD67331.1 - 5.9 7.3 11.3 11 6.4 0.1 4.5 3 1 1 4 4 4 0 zf-MYND-like zinc finger, mRNA-binding DUF2461 PF09365.10 EMD67332.1 - 0.005 16.8 0.4 0.0099 15.8 0.4 1.4 1 0 0 1 1 1 1 Conserved hypothetical protein (DUF2461) Y2_Tnp PF04986.13 EMD67332.1 - 0.12 12.4 0.1 0.26 11.3 0.1 1.5 1 0 0 1 1 1 0 Putative transposase Ribosomal_L19 PF01245.20 EMD67333.1 - 6.6e-13 48.6 0.2 1.2e-12 47.8 0.2 1.4 1 0 0 1 1 1 1 Ribosomal protein L19 NmrA PF05368.13 EMD67334.1 - 5.8e-68 228.9 0.0 7e-68 228.7 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EMD67334.1 - 2.4e-08 34.1 0.0 3.4e-08 33.6 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Asparaginase PF00710.20 EMD67335.1 - 2.7e-57 193.4 0.0 4.1e-57 192.8 0.0 1.3 1 0 0 1 1 1 1 Asparaginase, N-terminal Asparaginase_C PF17763.1 EMD67335.1 - 1.3e-26 93.1 0.0 3.5e-26 91.7 0.0 1.8 2 0 0 2 2 2 1 Glutaminase/Asparaginase C-terminal domain Ank_2 PF12796.7 EMD67335.1 - 1.4e-10 41.6 0.1 3.1e-07 30.9 0.1 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMD67335.1 - 5.5e-08 33.2 0.1 1.9e-05 25.1 0.1 2.7 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 EMD67335.1 - 6.2e-08 32.8 1.1 0.011 16.2 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 EMD67335.1 - 1.7e-06 27.9 0.1 0.044 14.3 0.1 3.5 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 EMD67335.1 - 2.2e-05 24.6 1.0 0.0048 17.2 0.1 3.1 2 1 2 4 4 4 2 Ankyrin repeats (many copies) NAP PF00956.18 EMD67337.1 - 5.4e-26 91.4 8.4 6.3e-25 87.9 2.7 2.3 1 1 1 2 2 2 2 Nucleosome assembly protein (NAP) BUD22 PF09073.10 EMD67337.1 - 0.015 14.7 12.4 0.02 14.3 12.4 1.2 1 0 0 1 1 1 0 BUD22 DUF4611 PF15387.6 EMD67337.1 - 0.58 10.4 20.1 0.49 10.6 9.4 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4611) PBP1_TM PF14812.6 EMD67337.1 - 4.4 7.7 25.9 5.3 7.5 11.5 3.1 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Glyco_hydro_1 PF00232.18 EMD67338.1 - 1.6e-103 346.6 0.2 2.4e-103 346.0 0.2 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 1 WD40 PF00400.32 EMD67338.1 - 8.7e-19 67.5 8.6 0.0012 19.6 0.4 6.3 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD67338.1 - 1.8e-13 50.6 0.0 0.00041 20.6 0.1 4.5 3 1 1 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EMD67338.1 - 0.00013 21.9 0.0 1.2 9.0 0.0 3.2 1 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 EMD67338.1 - 0.22 10.4 3.2 0.16 10.9 0.9 1.8 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein TP6A_N PF04406.14 EMD67340.1 - 1.5e-22 79.3 1.3 2.5e-22 78.6 0.3 1.9 2 0 0 2 2 2 1 Type IIB DNA topoisomerase CAF1A PF12253.8 EMD67341.1 - 6.6e-23 80.7 8.7 6.6e-23 80.7 8.7 2.7 2 0 0 2 2 2 1 Chromatin assembly factor 1 subunit A CAF-1_p150 PF11600.8 EMD67341.1 - 0.01 15.5 33.4 0.02 14.6 33.4 1.4 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal Tho2 PF11262.8 EMD67341.1 - 0.035 13.3 13.0 0.05 12.8 13.0 1.2 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 Pox_Ag35 PF03286.14 EMD67341.1 - 0.45 10.3 24.3 0.16 11.7 16.2 2.5 2 0 0 2 2 2 0 Pox virus Ag35 surface protein MCM3AP_GANP PF16769.5 EMD67341.1 - 0.65 8.2 11.2 0.91 7.7 11.2 1.1 1 0 0 1 1 1 0 MCM3AP domain of GANP LAP1C PF05609.12 EMD67341.1 - 1.1 8.3 17.5 0.47 9.5 12.5 2.1 2 0 0 2 2 2 0 Lamina-associated polypeptide 1C (LAP1C) Cwf_Cwc_15 PF04889.12 EMD67341.1 - 2.2 8.0 28.6 2.7 7.7 13.8 2.3 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Vfa1 PF08432.10 EMD67341.1 - 2.2 8.6 27.3 34 4.7 25.4 2.4 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 RR_TM4-6 PF06459.12 EMD67341.1 - 3.7 7.3 26.3 0.082 12.7 19.2 1.8 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Raftlin PF15250.6 EMD67341.1 - 4.9 5.8 13.0 9 4.9 13.0 1.3 1 0 0 1 1 1 0 Raftlin Peptidase_S64 PF08192.11 EMD67341.1 - 6.5 5.1 10.0 9.5 4.6 10.0 1.3 1 0 0 1 1 1 0 Peptidase family S64 Zip PF02535.22 EMD67341.1 - 7.9 5.6 6.0 14 4.8 6.0 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter Asp PF00026.23 EMD67342.1 - 1.7e-09 37.5 0.8 4.7e-09 36.1 0.8 1.8 1 1 0 1 1 1 1 Eukaryotic aspartyl protease Syndecan PF01034.20 EMD67342.1 - 0.0056 16.6 0.0 0.011 15.7 0.0 1.4 1 0 0 1 1 1 1 Syndecan domain Ribonucleas_3_3 PF14622.6 EMD67343.1 - 3.3e-28 98.4 0.0 9.3e-28 97.0 0.0 1.7 1 1 0 1 1 1 1 Ribonuclease-III-like Ribonuclease_3 PF00636.26 EMD67343.1 - 1.3e-06 28.9 0.0 1e-05 26.1 0.0 2.4 2 1 0 2 2 2 1 Ribonuclease III domain HAT_KAT11 PF08214.11 EMD67344.1 - 2.4e-102 342.8 0.0 3.2e-102 342.4 0.0 1.1 1 0 0 1 1 1 1 Histone acetylation protein Glyco_transf_21 PF13506.6 EMD67345.1 - 1.6e-13 50.5 0.2 1.4e-05 24.6 0.0 3.2 3 0 0 3 3 3 2 Glycosyl transferase family 21 Glyco_tranf_2_3 PF13641.6 EMD67345.1 - 3.5e-07 30.3 0.0 1.3e-06 28.5 0.0 1.9 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 EMD67345.1 - 0.011 15.6 0.0 0.15 11.9 0.0 2.4 1 1 0 1 1 1 0 Glycosyl transferase family 2 KleE PF17394.2 EMD67345.1 - 4.4 7.6 7.1 0.25 11.6 0.8 2.1 2 0 0 2 2 2 0 Uncharacterized KleE stable inheritance protein TrkH PF02386.16 EMD67346.1 - 3.7e-145 484.2 7.4 3.4e-144 481.0 5.6 2.0 2 0 0 2 2 2 2 Cation transport protein PhoR PF11808.8 EMD67346.1 - 0.015 15.7 0.9 7.3 7.1 0.1 3.1 2 0 0 2 2 2 0 Phosphate regulon sensor protein PhoR Glycogen_syn PF05693.13 EMD67347.1 - 0 1122.5 0.0 0 1122.2 0.0 1.0 1 0 0 1 1 1 1 Glycogen synthase Glycos_transf_1 PF00534.20 EMD67347.1 - 3.9e-06 26.5 0.0 0.0067 16.0 0.0 2.4 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 EMD67347.1 - 0.00014 22.4 0.0 0.00027 21.4 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_transf_4 PF13439.6 EMD67347.1 - 0.00014 21.9 0.2 0.00028 20.9 0.2 1.5 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_4 PF13692.6 EMD67347.1 - 0.00019 21.8 0.0 0.15 12.5 0.0 2.5 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_transf_5 PF08323.11 EMD67347.1 - 0.00078 19.2 0.1 0.0025 17.6 0.1 1.8 2 0 0 2 2 2 1 Starch synthase catalytic domain PH PF00169.29 EMD67348.1 - 1.3e-06 28.9 0.2 3.2e-06 27.6 0.2 1.6 1 0 0 1 1 1 1 PH domain DUF4670 PF15709.5 EMD67348.1 - 0.41 9.9 45.3 0.027 13.8 39.5 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4670) MMADHC PF10229.9 EMD67348.1 - 2.8 7.6 7.2 5.1 6.7 7.2 1.3 1 0 0 1 1 1 0 Methylmalonic aciduria and homocystinuria type D protein F-box-like PF12937.7 EMD67349.1 - 9.4e-06 25.4 0.0 2.5e-05 24.0 0.0 1.8 2 0 0 2 2 2 1 F-box-like LRR_4 PF12799.7 EMD67349.1 - 0.034 14.6 0.1 1.3e+02 3.2 0.0 4.4 4 1 1 5 5 5 0 Leucine Rich repeats (2 copies) zf-RanBP PF00641.18 EMD67350.1 - 1.4e-20 72.3 11.1 1.5e-10 40.2 2.2 2.3 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others RRM_1 PF00076.22 EMD67350.1 - 1e-07 31.7 0.0 2.9e-07 30.2 0.0 1.9 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNase_T PF00929.24 EMD67350.1 - 1.5e-06 28.8 0.0 2.2e-06 28.3 0.0 1.2 1 0 0 1 1 1 1 Exonuclease Mannosyl_trans3 PF11051.8 EMD67351.1 - 3.2e-59 200.6 0.3 6.2e-36 124.2 0.0 2.9 2 1 1 3 3 3 2 Mannosyltransferase putative Cnd3 PF12719.7 EMD67352.1 - 5.8e-83 278.5 1.8 1.7e-82 276.9 0.3 2.6 2 1 0 2 2 2 1 Nuclear condensing complex subunits, C-term domain HEAT PF02985.22 EMD67352.1 - 1.5e-11 43.5 1.4 0.02 15.1 0.0 6.0 6 0 0 6 6 6 3 HEAT repeat HEAT_2 PF13646.6 EMD67352.1 - 5.8e-07 29.8 4.5 0.0015 18.9 0.7 4.2 3 1 0 3 3 3 2 HEAT repeats Cnd1 PF12717.7 EMD67352.1 - 0.00017 21.7 4.9 0.5 10.4 0.0 5.0 4 1 1 5 5 5 3 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 EMD67352.1 - 0.011 16.2 2.0 1 9.9 0.2 4.3 3 1 1 4 4 4 0 HEAT-like repeat Cohesin_HEAT PF12765.7 EMD67352.1 - 0.069 13.5 1.3 16 5.9 0.1 3.1 2 0 0 2 2 2 0 HEAT repeat associated with sister chromatid cohesion Vac14_Fab1_bd PF12755.7 EMD67352.1 - 0.072 13.7 0.0 0.66 10.6 0.0 2.7 2 0 0 2 2 2 0 Vacuolar 14 Fab1-binding region PALP PF00291.25 EMD67353.1 - 1.6e-67 228.0 0.1 1.9e-67 227.8 0.1 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme NUDIX-like PF09296.11 EMD67354.1 - 4.6e-17 62.5 0.0 2.6e-16 60.1 0.0 2.1 2 0 0 2 2 2 1 NADH pyrophosphatase-like rudimentary NUDIX domain NUDIX PF00293.28 EMD67354.1 - 5.2e-16 58.9 0.4 1.2e-15 57.7 0.4 1.5 1 0 0 1 1 1 1 NUDIX domain zf-NADH-PPase PF09297.11 EMD67354.1 - 0.0009 18.9 0.6 0.0024 17.5 0.6 1.7 1 0 0 1 1 1 1 NADH pyrophosphatase zinc ribbon domain COG2 PF06148.11 EMD67355.1 - 3.4e-35 121.0 0.6 3.4e-35 121.0 0.6 1.7 2 0 0 2 2 2 1 COG (conserved oligomeric Golgi) complex component, COG2 Vps51 PF08700.11 EMD67355.1 - 7.9e-05 22.7 0.7 0.00026 21.0 0.0 2.2 2 0 0 2 2 2 1 Vps51/Vps67 COG5 PF10392.9 EMD67355.1 - 0.0011 19.1 0.1 0.0028 17.8 0.1 1.6 1 0 0 1 1 1 1 Golgi transport complex subunit 5 Cwf_Cwc_15 PF04889.12 EMD67355.1 - 5 6.8 10.3 0.29 10.9 3.1 2.2 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Ribosomal_L1 PF00687.21 EMD67356.1 - 6.4e-30 104.4 0.0 1.3e-29 103.4 0.0 1.5 1 1 0 1 1 1 1 Ribosomal protein L1p/L10e family Acetyltransf_3 PF13302.7 EMD67357.1 - 2.3e-19 70.4 0.0 2.7e-19 70.2 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EMD67357.1 - 0.0022 18.2 0.0 0.0036 17.5 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Lipase_GDSL PF00657.22 EMD67358.1 - 8.1e-05 22.7 0.1 0.00012 22.1 0.1 1.3 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.6 EMD67358.1 - 0.00035 21.0 0.4 0.0012 19.3 0.4 1.8 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Scramblase PF03803.15 EMD67360.1 - 1.2e-52 178.4 0.0 3.8e-29 101.6 0.0 2.9 1 1 1 2 2 2 2 Scramblase SRP1_TIP1 PF00660.17 EMD67360.1 - 0.051 13.7 0.0 0.095 12.8 0.0 1.4 1 0 0 1 1 1 0 Seripauperin and TIP1 family tRNA_int_endo PF01974.17 EMD67361.1 - 1.2e-18 67.0 0.0 4.2e-18 65.2 0.0 1.9 2 0 0 2 2 2 1 tRNA intron endonuclease, catalytic C-terminal domain tRNA_int_endo_N PF02778.14 EMD67361.1 - 0.0015 18.1 0.0 0.021 14.5 0.0 2.2 2 0 0 2 2 2 1 tRNA intron endonuclease, N-terminal domain Asn_synthase PF00733.21 EMD67362.1 - 6.6e-75 253.0 0.0 9e-75 252.5 0.0 1.1 1 0 0 1 1 1 1 Asparagine synthase GATase_7 PF13537.6 EMD67362.1 - 1.7e-34 118.4 0.0 6.4e-34 116.5 0.0 1.9 2 0 0 2 2 2 1 Glutamine amidotransferase domain GATase_6 PF13522.6 EMD67362.1 - 1.6e-29 102.8 0.0 4e-29 101.5 0.0 1.7 1 0 0 1 1 1 1 Glutamine amidotransferase domain DUF3700 PF12481.8 EMD67362.1 - 0.044 13.2 0.0 0.1 12.1 0.0 1.5 1 0 0 1 1 1 0 Aluminium induced protein CAF1C_H4-bd PF12265.8 EMD67363.1 - 5.2e-25 87.5 1.4 2.2e-24 85.5 0.3 2.5 3 0 0 3 3 3 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 EMD67363.1 - 2.5e-19 69.2 5.0 0.001 19.8 0.3 6.3 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD67363.1 - 0.00023 21.4 0.1 0.75 10.1 0.0 4.4 2 1 2 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain Ig_GlcNase PF18368.1 EMD67364.1 - 2.9e-25 88.5 0.0 6.9e-25 87.2 0.0 1.7 1 0 0 1 1 1 1 Exo-beta-D-glucosaminidase Ig-fold domain Glyco_hydro_2 PF00703.21 EMD67364.1 - 2.6e-09 37.7 0.0 5.7e-09 36.6 0.0 1.6 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 Glyco_hydro_2_N PF02837.18 EMD67364.1 - 2.6e-06 27.5 0.2 6.5e-06 26.2 0.2 1.7 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Ig_mannosidase PF17753.1 EMD67364.1 - 0.00016 21.4 0.0 0.00042 20.0 0.0 1.7 1 0 0 1 1 1 1 Ig-fold domain Glyco_hydro_2_C PF02836.17 EMD67364.1 - 0.00064 18.9 0.1 0.0013 17.9 0.0 1.5 2 0 0 2 2 2 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_72 PF03198.14 EMD67364.1 - 0.098 11.9 0.0 0.16 11.2 0.0 1.2 1 0 0 1 1 1 0 Glucanosyltransferase CoaE PF01121.20 EMD67365.1 - 2.3e-43 147.9 0.0 3.8e-43 147.2 0.0 1.3 1 0 0 1 1 1 1 Dephospho-CoA kinase AAA_33 PF13671.6 EMD67365.1 - 0.00091 19.4 0.0 0.0093 16.1 0.0 2.3 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EMD67365.1 - 0.046 14.3 0.2 0.52 10.9 0.0 2.3 2 1 0 2 2 2 0 AAA domain Acyl-CoA_dh_1 PF00441.24 EMD67369.1 - 1.1e-30 106.8 0.7 1.6e-30 106.3 0.7 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 EMD67369.1 - 2.1e-23 82.3 0.1 3.4e-23 81.6 0.1 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 EMD67369.1 - 4.6e-21 75.6 0.1 1.1e-20 74.4 0.1 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 EMD67369.1 - 0.034 14.4 0.0 0.064 13.5 0.0 1.4 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase, C-terminal domain adh_short_C2 PF13561.6 EMD67370.1 - 1.5e-60 204.7 0.1 1.7e-60 204.5 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EMD67370.1 - 3.2e-42 144.2 0.4 3.7e-42 144.0 0.4 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EMD67370.1 - 8.8e-15 55.1 0.2 1.3e-14 54.5 0.2 1.2 1 0 0 1 1 1 1 KR domain Spore_IV_A PF09547.10 EMD67370.1 - 0.054 12.4 0.0 0.077 11.9 0.0 1.1 1 0 0 1 1 1 0 Stage IV sporulation protein A (spore_IV_A) DUF4164 PF13747.6 EMD67372.1 - 0.32 11.3 5.6 0.14 12.4 1.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4164) DIOX_N PF14226.6 EMD67373.1 - 1.8e-25 89.9 0.0 2.8e-25 89.4 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EMD67373.1 - 3.2e-21 75.7 0.0 5.6e-21 74.9 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Amidohydro_3 PF07969.11 EMD67374.1 - 3.5e-78 264.2 0.5 4e-78 264.0 0.5 1.0 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_1 PF01979.20 EMD67374.1 - 1e-15 58.0 0.0 5.3e-12 45.7 0.0 3.2 2 1 0 2 2 2 2 Amidohydrolase family YbjQ_1 PF01906.17 EMD67375.1 - 1.4e-21 77.1 0.6 1.7e-21 76.8 0.6 1.1 1 0 0 1 1 1 1 Putative heavy-metal-binding SurA_N_2 PF13623.6 EMD67375.1 - 0.069 13.0 0.0 0.092 12.6 0.0 1.1 1 0 0 1 1 1 0 SurA N-terminal domain Alpha-L-AF_C PF06964.12 EMD67376.1 - 2e-16 60.6 0.0 3e-16 60.0 0.0 1.3 1 0 0 1 1 1 1 Alpha-L-arabinofuranosidase C-terminal domain cobW PF02492.19 EMD67377.1 - 5.3e-50 169.5 3.2 7.5e-48 162.4 3.2 2.2 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.14 EMD67377.1 - 7.3e-19 67.5 0.0 2.2e-14 53.1 0.0 2.7 2 0 0 2 2 2 2 Cobalamin synthesis protein cobW C-terminal domain Gp_dh_N PF00044.24 EMD67377.1 - 0.00016 22.0 0.0 0.00039 20.7 0.0 1.6 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain AAA_16 PF13191.6 EMD67377.1 - 0.013 15.9 1.2 0.069 13.5 0.0 2.5 2 1 1 3 3 3 0 AAA ATPase domain MeaB PF03308.16 EMD67377.1 - 0.015 14.3 0.6 2.2 7.2 0.1 2.8 2 1 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Viral_helicase1 PF01443.18 EMD67377.1 - 0.019 14.7 0.1 0.053 13.2 0.0 1.7 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase MobB PF03205.14 EMD67377.1 - 0.023 14.6 0.0 0.048 13.6 0.0 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B TsaE PF02367.17 EMD67377.1 - 0.028 14.4 1.5 0.03 14.3 0.0 1.8 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE GTP_EFTU PF00009.27 EMD67377.1 - 0.036 13.6 0.4 1.1 8.8 0.1 2.5 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_33 PF13671.6 EMD67377.1 - 0.069 13.3 0.0 0.16 12.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 EMD67377.1 - 0.087 12.1 0.0 0.19 11.0 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin Herpes_LMP2 PF07415.11 EMD67377.1 - 3.2 6.4 3.4 6.1 5.5 3.4 1.4 1 0 0 1 1 1 0 Gammaherpesvirus latent membrane protein (LMP2) protein Melibiase_2 PF16499.5 EMD67378.1 - 9.8e-57 192.3 6.5 1.8e-39 135.6 2.3 2.3 2 0 0 2 2 2 2 Alpha galactosidase A Melibiase_C PF17801.1 EMD67378.1 - 9.3e-13 48.1 0.4 1.8e-10 40.8 0.1 2.6 2 0 0 2 2 2 2 Alpha galactosidase C-terminal beta sandwich domain Melibiase PF02065.18 EMD67378.1 - 3.4e-05 23.0 0.0 6.2e-05 22.1 0.0 1.4 1 0 0 1 1 1 1 Melibiase Glyco_hyd_65N_2 PF14498.6 EMD67379.1 - 4.3e-61 206.8 0.3 6.2e-61 206.3 0.3 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, N-terminal domain MCM PF00493.23 EMD67380.1 - 1.9e-104 347.7 0.1 5e-104 346.3 0.0 1.7 2 0 0 2 2 2 1 MCM P-loop domain MCM_OB PF17207.3 EMD67380.1 - 7.7e-36 122.7 0.2 1.5e-35 121.8 0.2 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EMD67380.1 - 4e-29 100.9 1.7 9.2e-29 99.7 1.7 1.6 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 EMD67380.1 - 5.8e-16 59.0 0.4 1.5e-15 57.7 0.4 1.7 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 EMD67380.1 - 3.8e-06 26.5 0.0 0.00076 18.9 0.0 2.4 1 1 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EMD67380.1 - 2.3e-05 24.4 0.0 5.9e-05 23.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 EMD67380.1 - 0.00035 20.5 0.0 0.0013 18.6 0.0 2.0 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EMD67380.1 - 0.043 13.5 0.0 1.6 8.4 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA PF00004.29 EMD67380.1 - 0.13 12.7 0.0 0.45 10.9 0.0 2.0 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Hap4_Hap_bind PF10297.9 EMD67382.1 - 1.7e-07 31.1 6.3 4.7e-07 29.7 6.3 1.8 1 0 0 1 1 1 1 Minimal binding motif of Hap4 for binding to Hap2/3/5 bZIP_1 PF00170.21 EMD67382.1 - 2e-05 24.6 14.7 0.00044 20.3 13.6 2.4 1 1 1 2 2 2 2 bZIP transcription factor DegS PF05384.11 EMD67382.1 - 0.0092 15.5 1.1 0.014 14.9 0.7 1.5 1 1 0 1 1 1 1 Sensor protein DegS HALZ PF02183.18 EMD67382.1 - 0.02 15.1 0.6 0.043 14.0 0.3 1.7 2 0 0 2 2 2 0 Homeobox associated leucine zipper Jnk-SapK_ap_N PF09744.9 EMD67382.1 - 7.2 6.8 10.0 15 5.8 10.0 1.4 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 PE PF00934.20 EMD67383.1 - 0.056 13.8 1.6 0.073 13.4 1.6 1.3 1 0 0 1 1 1 0 PE family A_thal_3526 PF09713.10 EMD67384.1 - 0.21 11.8 0.7 0.49 10.7 0.7 1.6 1 0 0 1 1 1 0 Plant protein 1589 of unknown function (A_thal_3526) Glyco_hydro_61 PF03443.14 EMD67389.1 - 1e-48 166.0 0.1 1.2e-48 165.7 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 NAR2 PF16974.5 EMD67389.1 - 0.098 12.0 0.0 0.19 11.1 0.0 1.4 1 0 0 1 1 1 0 High-affinity nitrate transporter accessory Transglut_core PF01841.19 EMD67390.1 - 1.7e-12 47.7 0.0 4.4e-12 46.4 0.0 1.7 1 0 0 1 1 1 1 Transglutaminase-like superfamily SH3_2 PF07653.17 EMD67390.1 - 1.9e-08 33.8 0.1 4.2e-08 32.7 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EMD67390.1 - 2.5e-07 30.2 0.1 5.4e-07 29.1 0.1 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EMD67390.1 - 0.0011 18.8 0.1 0.0022 17.8 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain CCDC32 PF14989.6 EMD67390.1 - 0.068 13.2 1.5 0.13 12.2 1.5 1.4 1 0 0 1 1 1 0 Coiled-coil domain containing 32 tRNA-synt_1c PF00749.21 EMD67391.1 - 1.1e-104 349.7 0.0 1.5e-104 349.3 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 EMD67391.1 - 5e-34 117.7 0.1 1e-33 116.7 0.1 1.6 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain Glyco_transf_88 PF16849.5 EMD67391.1 - 0.098 11.6 0.0 0.18 10.7 0.0 1.4 1 0 0 1 1 1 0 Glycosyltransferase family 88 GFA PF04828.14 EMD67392.1 - 8.8e-10 38.8 2.0 8.8e-10 38.8 2.0 1.8 2 0 0 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme Exo_endo_phos PF03372.23 EMD67393.1 - 3.5e-07 30.0 0.0 1e-06 28.5 0.0 1.8 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family zf-CHY PF05495.12 EMD67394.1 - 1.1e-13 51.5 14.5 2.3e-13 50.4 14.5 1.5 1 1 0 1 1 1 1 CHY zinc finger zinc_ribbon_9 PF14369.6 EMD67394.1 - 0.011 15.9 3.0 0.011 15.9 3.0 2.4 1 1 2 3 3 3 0 zinc-ribbon HypA PF01155.19 EMD67394.1 - 0.02 14.9 1.3 0.02 14.9 1.3 2.3 2 1 1 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Zn-ribbon_8 PF09723.10 EMD67394.1 - 0.026 14.7 4.9 0.026 14.7 4.9 3.0 2 1 2 4 4 4 0 Zinc ribbon domain DpnI PF06044.12 EMD67394.1 - 0.27 10.8 5.3 0.068 12.8 1.4 1.8 1 1 1 2 2 2 0 Dam-replacing family zinc-ribbons_6 PF07191.12 EMD67394.1 - 0.36 10.9 12.2 0.19 11.7 2.1 2.4 1 1 2 3 3 3 0 zinc-ribbons zinc_ribbon_10 PF10058.9 EMD67394.1 - 3.2 7.6 9.3 15 5.4 6.7 2.3 2 0 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein Evr1_Alr PF04777.13 EMD67394.1 - 3.4 8.2 10.8 13 6.4 6.4 2.6 1 1 1 2 2 2 0 Erv1 / Alr family zinc_ribbon_4 PF13717.6 EMD67394.1 - 5.4 7.0 13.5 1 9.3 0.4 3.6 3 0 0 3 3 3 0 zinc-ribbon domain Proteasome PF00227.26 EMD67395.1 - 3.3e-56 189.8 0.1 4.4e-56 189.4 0.1 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EMD67395.1 - 6.3e-13 48.1 0.3 2.1e-12 46.5 0.1 2.0 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature Tma16 PF11176.8 EMD67395.1 - 0.029 14.3 0.5 0.14 12.0 0.1 1.9 1 1 0 2 2 2 0 Translation machinery-associated protein 16 Terminase_5 PF06056.12 EMD67395.1 - 0.16 11.8 0.1 0.37 10.7 0.1 1.6 1 0 0 1 1 1 0 Putative ATPase subunit of terminase (gpP-like) FAD-oxidase_C PF02913.19 EMD67396.1 - 5.3e-62 209.7 0.0 7.1e-62 209.3 0.0 1.2 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 EMD67396.1 - 7.4e-37 126.2 0.1 1.3e-36 125.4 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain Amidohydro_2 PF04909.14 EMD67397.1 - 3e-32 112.6 0.1 5e-32 111.8 0.1 1.3 1 1 0 1 1 1 1 Amidohydrolase MTHFR PF02219.17 EMD67398.1 - 2.2e-100 335.7 0.0 3.9e-100 334.9 0.0 1.4 2 0 0 2 2 2 1 Methylenetetrahydrofolate reductase DUF3449 PF11931.8 EMD67399.1 - 1.8e-77 259.3 0.5 1.8e-77 259.3 0.5 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF3449) SF3A3 PF16837.5 EMD67399.1 - 8.1e-27 93.6 1.6 2.1e-26 92.2 1.6 1.8 1 0 0 1 1 1 1 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 zf-met PF12874.7 EMD67399.1 - 2.1e-09 37.4 1.8 1.7e-07 31.4 0.8 2.5 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EMD67399.1 - 5.4e-08 32.9 0.6 5.4e-08 32.9 0.6 2.6 2 1 0 2 2 2 1 Zinc-finger double-stranded RNA-binding SF3a60_bindingd PF12108.8 EMD67399.1 - 1.7e-07 31.0 0.0 3.9e-07 29.8 0.0 1.7 1 0 0 1 1 1 1 Splicing factor SF3a60 binding domain zf-C2H2_2 PF12756.7 EMD67399.1 - 0.0024 18.2 0.9 0.017 15.5 0.1 2.5 2 0 0 2 2 2 1 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 EMD67399.1 - 0.23 12.4 0.8 49 5.2 0.1 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger PRP9_N PF16958.5 EMD67399.1 - 4 7.5 23.6 0.068 13.2 1.3 4.0 4 2 2 6 6 6 0 Pre-mRNA-splicing factor PRP9 N-terminus DEAD PF00270.29 EMD67400.1 - 6.2e-41 140.1 0.1 1.1e-40 139.3 0.1 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EMD67400.1 - 3.9e-32 110.9 0.1 1.5e-31 109.0 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain AAA_30 PF13604.6 EMD67400.1 - 0.00036 20.3 0.0 0.00055 19.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EMD67400.1 - 0.00075 19.8 0.1 0.0062 16.9 0.1 2.2 2 0 0 2 2 2 1 AAA domain ResIII PF04851.15 EMD67400.1 - 0.0014 18.7 0.0 0.0027 17.7 0.0 1.5 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit Flavi_DEAD PF07652.14 EMD67400.1 - 0.011 15.7 0.3 0.039 13.9 0.1 2.2 1 1 0 1 1 1 0 Flavivirus DEAD domain Helicase_RecD PF05127.14 EMD67400.1 - 0.051 13.4 0.0 0.093 12.6 0.0 1.5 1 0 0 1 1 1 0 Helicase TniB PF05621.11 EMD67400.1 - 0.066 12.6 0.0 0.16 11.3 0.0 1.6 1 0 0 1 1 1 0 Bacterial TniB protein DUF5393 PF17371.2 EMD67400.1 - 0.076 11.1 0.1 0.14 10.3 0.0 1.4 2 0 0 2 2 2 0 Family of unknown function (DUF5393) tRNA-synt_1b PF00579.25 EMD67400.1 - 0.13 11.6 0.0 0.29 10.4 0.0 1.6 2 0 0 2 2 2 0 tRNA synthetases class I (W and Y) UQ_con PF00179.26 EMD67403.1 - 5.3e-27 94.2 0.0 5.8e-27 94.1 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme DUF2293 PF10056.9 EMD67407.1 - 3.3e-31 107.3 1.5 4.1e-31 107.1 0.1 1.8 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2293) Anoctamin PF04547.12 EMD67408.1 - 5.8e-104 348.4 1.1 6.9e-104 348.2 1.1 1.0 1 0 0 1 1 1 1 Calcium-activated chloride channel Glyco_hydro_10 PF00331.20 EMD67409.1 - 1.4e-99 333.3 3.2 1.6e-99 333.1 3.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 10 NAD_binding_10 PF13460.6 EMD67410.1 - 2.9e-12 46.8 0.0 4.5e-12 46.2 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EMD67410.1 - 2.1e-09 37.3 0.0 3.7e-09 36.5 0.0 1.4 1 0 0 1 1 1 1 NmrA-like family Semialdhyde_dh PF01118.24 EMD67410.1 - 0.00026 21.4 0.1 0.00049 20.5 0.1 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain DapB_N PF01113.20 EMD67410.1 - 0.00052 20.1 0.0 0.0009 19.4 0.0 1.4 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Epimerase PF01370.21 EMD67410.1 - 0.0022 17.5 0.0 0.0038 16.7 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GFO_IDH_MocA PF01408.22 EMD67410.1 - 0.013 16.3 0.1 0.023 15.5 0.1 1.3 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold Ldh_1_N PF00056.23 EMD67410.1 - 0.03 14.4 0.1 0.053 13.6 0.1 1.4 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 EMD67410.1 - 0.13 12.3 0.2 0.22 11.6 0.2 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase DUF2325 PF10087.9 EMD67410.1 - 0.15 12.2 0.0 0.35 11.0 0.0 1.6 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2325) PucR PF07905.11 EMD67410.1 - 0.19 12.0 0.0 0.47 10.7 0.0 1.6 2 0 0 2 2 2 0 Purine catabolism regulatory protein-like family ADH_N PF08240.12 EMD67411.1 - 4.5e-33 113.4 1.1 6.9e-33 112.8 0.7 1.5 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EMD67411.1 - 1.2e-15 57.6 0.0 2.1e-15 56.8 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EMD67411.1 - 6.9e-09 36.9 0.0 1.1e-08 36.1 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EMD67411.1 - 8.7e-07 28.6 0.0 1.3e-06 28.1 0.0 1.3 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus Staph_opine_DH PF10100.9 EMD67411.1 - 0.086 11.5 0.0 0.11 11.1 0.0 1.1 1 0 0 1 1 1 0 Staphylopine dehydrogenase RNA_lig_T4_1 PF09511.10 EMD67411.1 - 0.11 12.3 0.0 0.18 11.7 0.0 1.2 1 0 0 1 1 1 0 RNA ligase FAD_binding_3 PF01494.19 EMD67411.1 - 0.21 10.8 0.0 0.32 10.2 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain ThiF PF00899.21 EMD67411.1 - 0.41 9.9 2.2 0.33 10.3 0.4 1.6 2 0 0 2 2 2 0 ThiF family DUF572 PF04502.13 EMD67414.1 - 1.4e-71 241.9 14.4 1.9e-71 241.4 14.4 1.3 1 1 0 1 1 1 1 Family of unknown function (DUF572) zf-ACC PF17848.1 EMD67414.1 - 0.048 13.7 2.4 0.23 11.6 0.3 2.3 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain zf-FCS PF06467.14 EMD67414.1 - 1.2 9.1 4.0 3.5 7.6 0.4 2.3 2 0 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif TPR_1 PF00515.28 EMD67415.1 - 3.1e-27 93.2 0.2 4.2e-06 26.4 0.2 9.7 10 0 0 10 10 10 4 Tetratricopeptide repeat ANAPC3 PF12895.7 EMD67415.1 - 5e-27 93.9 6.3 4e-23 81.4 0.2 4.7 4 2 1 5 5 5 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.17 EMD67415.1 - 3.4e-25 86.1 7.8 0.00015 21.6 0.1 10.3 11 0 0 11 11 11 4 Tetratricopeptide repeat TPR_19 PF14559.6 EMD67415.1 - 4.7e-21 75.1 2.3 0.0021 18.5 0.0 7.1 4 2 4 9 9 8 6 Tetratricopeptide repeat TPR_8 PF13181.6 EMD67415.1 - 4.1e-19 67.1 0.1 0.00015 21.7 0.1 8.7 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_12 PF13424.6 EMD67415.1 - 5.8e-17 61.8 9.9 8.3e-07 29.2 0.0 7.7 7 3 1 8 8 7 4 Tetratricopeptide repeat TPR_16 PF13432.6 EMD67415.1 - 2.9e-12 47.0 7.3 0.19 12.4 0.2 8.0 6 2 1 8 8 8 3 Tetratricopeptide repeat TPR_14 PF13428.6 EMD67415.1 - 4.3e-10 39.5 13.0 2.6 9.1 0.0 8.9 5 3 5 10 10 9 2 Tetratricopeptide repeat TPR_11 PF13414.6 EMD67415.1 - 1.4e-07 31.1 1.3 1.3 8.8 0.0 6.4 7 1 1 8 8 8 2 TPR repeat TPR_7 PF13176.6 EMD67415.1 - 8.4e-07 28.6 8.8 0.18 11.9 0.0 7.2 9 0 0 9 9 8 1 Tetratricopeptide repeat TPR_6 PF13174.6 EMD67415.1 - 3.8e-06 27.2 6.2 1.2 10.0 0.1 7.4 8 0 0 8 8 7 1 Tetratricopeptide repeat TPR_15 PF13429.6 EMD67415.1 - 6.6e-06 25.5 0.2 4.1 6.5 0.0 4.8 3 1 2 5 5 5 1 Tetratricopeptide repeat TPR_17 PF13431.6 EMD67415.1 - 8.3e-05 22.7 0.0 61 4.3 0.0 6.8 7 0 0 7 7 6 0 Tetratricopeptide repeat TPR_10 PF13374.6 EMD67415.1 - 0.00021 21.0 1.4 1.1 9.2 0.0 5.4 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_MalT PF17874.1 EMD67415.1 - 0.0018 17.7 3.8 3.2 7.0 0.2 4.4 4 3 0 6 6 6 2 MalT-like TPR region TPR_9 PF13371.6 EMD67415.1 - 0.0031 17.6 8.7 1.7 8.9 0.4 5.4 5 1 1 6 6 6 1 Tetratricopeptide repeat FAT PF02259.23 EMD67415.1 - 0.011 15.0 0.1 3.6 6.7 0.0 2.4 2 0 0 2 2 2 0 FAT domain ATP11 PF06644.11 EMD67415.1 - 0.011 15.5 0.1 0.011 15.5 0.1 1.5 2 0 0 2 2 1 0 ATP11 protein HrpB1_HrpK PF09613.10 EMD67415.1 - 0.11 12.1 0.1 7.3 6.2 0.0 3.0 2 0 0 2 2 2 0 Bacterial type III secretion protein (HrpB1_HrpK) Fis1_TPR_C PF14853.6 EMD67415.1 - 0.89 9.7 8.9 1.3 9.2 0.2 4.9 6 0 0 6 6 6 0 Fis1 C-terminal tetratricopeptide repeat bZIP_1 PF00170.21 EMD67415.1 - 5.1 7.3 7.7 4 7.6 4.6 2.3 1 1 1 2 2 2 0 bZIP transcription factor EMP24_GP25L PF01105.24 EMD67417.1 - 5.8e-46 156.7 2.5 6.6e-46 156.5 2.5 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD USP7_ICP0_bdg PF12436.8 EMD67418.1 - 1.3e-82 276.7 0.5 6.4e-81 271.2 0.1 2.5 2 0 0 2 2 2 1 ICP0-binding domain of Ubiquitin-specific protease 7 USP7_C2 PF14533.6 EMD67418.1 - 1.6e-69 233.7 0.6 1.3e-68 230.8 0.1 2.6 2 1 1 3 3 3 1 Ubiquitin-specific protease C-terminal UCH PF00443.29 EMD67418.1 - 3.8e-47 160.9 0.9 9.6e-47 159.6 0.2 1.9 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EMD67418.1 - 1.5e-20 74.1 0.0 5.1e-20 72.3 0.0 1.9 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase MATH PF00917.26 EMD67418.1 - 2.9e-08 33.8 0.0 1.2e-07 31.9 0.0 2.1 1 1 0 1 1 1 1 MATH domain HTH_Tnp_1 PF01527.20 EMD67418.1 - 0.0056 17.0 0.1 0.055 13.8 0.1 2.5 1 1 1 2 2 2 1 Transposase Rad60-SLD PF11976.8 EMD67418.1 - 0.0083 15.9 0.1 4 7.3 0.0 3.1 2 1 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like BCDHK_Adom3 PF10436.9 EMD67419.1 - 1.4e-33 116.0 0.1 2.3e-33 115.3 0.1 1.3 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 EMD67419.1 - 1.5e-05 25.5 0.0 0.0001 22.8 0.0 2.1 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Oxidored_molyb PF00174.19 EMD67422.1 - 8.6e-60 201.3 0.0 1.3e-59 200.7 0.0 1.2 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain Mo-co_dimer PF03404.16 EMD67422.1 - 1.2e-25 90.2 1.0 2.3e-25 89.2 1.0 1.4 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain UQ_con PF00179.26 EMD67423.1 - 5.8e-52 175.1 0.0 6.5e-52 174.9 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EMD67423.1 - 0.057 13.1 0.0 0.13 12.0 0.0 1.6 1 1 0 1 1 1 0 Prokaryotic E2 family B FAD_binding_8 PF08022.12 EMD67424.1 - 2.4e-20 72.7 0.0 4.8e-20 71.7 0.0 1.5 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.12 EMD67424.1 - 8e-18 65.0 0.0 2e-17 63.7 0.0 1.7 2 0 0 2 2 2 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.19 EMD67424.1 - 5e-11 42.8 7.6 5e-11 42.8 7.6 1.9 1 1 0 1 1 1 1 Ferric reductase like transmembrane component EF-hand_7 PF13499.6 EMD67424.1 - 0.00039 20.8 0.6 0.0021 18.4 0.3 2.2 2 0 0 2 2 2 1 EF-hand domain pair FAD_binding_6 PF00970.24 EMD67424.1 - 0.026 14.9 0.0 0.062 13.7 0.0 1.6 1 0 0 1 1 1 0 Oxidoreductase FAD-binding domain EF-hand_1 PF00036.32 EMD67424.1 - 0.17 11.5 1.3 0.36 10.5 0.7 1.9 2 0 0 2 2 2 0 EF hand Shugoshin_N PF07558.11 EMD67424.1 - 0.23 11.3 0.3 0.56 10.1 0.3 1.6 1 0 0 1 1 1 0 Shugoshin N-terminal coiled-coil region Abhydrolase_3 PF07859.13 EMD67425.1 - 4.2e-28 98.6 0.0 5.6e-28 98.3 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Oxidored_q6 PF01058.22 EMD67426.1 - 1e-22 80.3 0.1 1.4e-22 79.9 0.1 1.2 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase, 20 Kd subunit Response_reg PF00072.24 EMD67427.1 - 3.1e-13 49.9 0.0 5.5e-13 49.1 0.0 1.4 1 0 0 1 1 1 1 Response regulator receiver domain Glyco_transf_25 PF01755.17 EMD67428.1 - 3.2e-11 43.5 0.0 2e-10 40.9 0.0 2.0 1 1 0 1 1 1 1 Glycosyltransferase family 25 (LPS biosynthesis protein) Glyco_transf_34 PF05637.12 EMD67429.1 - 1.5e-09 38.0 0.1 1.1e-05 25.3 0.0 2.2 1 1 1 2 2 2 2 galactosyl transferase GMA12/MNN10 family Stealth_CR2 PF11380.8 EMD67430.1 - 1.4e-15 57.3 0.5 7.6e-14 51.8 0.2 2.8 2 1 0 2 2 2 1 Stealth protein CR2, conserved region 2 Stealth_CR1 PF17101.5 EMD67430.1 - 6.4e-10 38.6 0.0 1.4e-09 37.5 0.0 1.6 1 0 0 1 1 1 1 Stealth protein CR1, conserved region 1 Stealth_CR4 PF17103.5 EMD67430.1 - 5e-06 26.3 0.0 1.2e-05 25.1 0.0 1.6 1 0 0 1 1 1 1 Stealth protein CR4, conserved region 4 Stealth_CR3 PF17102.5 EMD67430.1 - 0.00093 19.1 0.6 0.0021 17.9 0.6 1.7 1 0 0 1 1 1 1 Stealth protein CR3, conserved region 3 Head_binding PF09008.10 EMD67431.1 - 0.032 14.5 1.6 0.098 12.9 1.6 1.8 1 0 0 1 1 1 0 Head binding Acyl_transf_3 PF01757.22 EMD67432.1 - 2.8e-23 82.6 29.0 5e-23 81.7 29.0 1.4 1 1 0 1 1 1 1 Acyltransferase family FAD_binding_3 PF01494.19 EMD67433.1 - 1.1e-17 64.4 0.2 1.5e-17 63.9 0.2 1.2 1 0 0 1 1 1 1 FAD binding domain Trp_halogenase PF04820.14 EMD67433.1 - 9.7e-07 28.0 4.0 0.0011 17.9 0.2 2.5 2 1 0 2 2 2 2 Tryptophan halogenase Pyr_redox_2 PF07992.14 EMD67433.1 - 2.1e-06 27.2 0.3 0.0081 15.4 0.0 2.8 1 1 2 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EMD67433.1 - 5.7e-05 22.9 7.1 0.0003 20.5 0.8 2.5 2 1 1 3 3 3 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EMD67433.1 - 0.00074 19.7 1.0 0.00074 19.7 1.0 2.5 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 EMD67433.1 - 0.0058 15.7 3.5 0.071 12.1 3.5 2.2 1 1 0 1 1 1 1 Lycopene cyclase protein NAD_binding_9 PF13454.6 EMD67433.1 - 0.012 15.6 1.6 0.17 11.8 0.1 2.9 3 0 0 3 3 3 0 FAD-NAD(P)-binding DUF3297 PF11730.8 EMD67433.1 - 0.043 13.7 0.1 0.09 12.7 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3297) FAD_binding_2 PF00890.24 EMD67433.1 - 0.15 11.1 3.8 0.065 12.3 1.2 1.7 2 0 0 2 2 2 0 FAD binding domain Fungal_trans PF04082.18 EMD67436.1 - 2.1e-05 23.7 1.1 8.7e-05 21.7 0.1 1.9 2 0 0 2 2 2 1 Fungal specific transcription factor domain Glyco_hydro_11 PF00457.17 EMD67437.1 - 1e-49 168.6 18.0 1.3e-49 168.2 18.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 11 AtuA PF07287.11 EMD67438.1 - 3.3e-23 82.0 0.0 4.3e-23 81.6 0.0 1.1 1 0 0 1 1 1 1 Acyclic terpene utilisation family protein AtuA NAD_binding_8 PF13450.6 EMD67439.1 - 4.9e-08 33.1 0.0 1.3e-07 31.8 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EMD67439.1 - 0.00015 21.5 0.0 0.13 11.8 0.0 2.9 1 1 2 3 3 3 2 FAD dependent oxidoreductase FMO-like PF00743.19 EMD67439.1 - 0.00081 17.9 0.0 0.0021 16.6 0.0 1.7 1 1 0 1 1 1 1 Flavin-binding monooxygenase-like K_oxygenase PF13434.6 EMD67439.1 - 0.0033 16.6 0.0 0.92 8.6 0.0 2.3 2 0 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 EMD67439.1 - 0.1 12.5 0.0 0.22 11.5 0.0 1.4 1 0 0 1 1 1 0 FAD-NAD(P)-binding Thi4 PF01946.17 EMD67439.1 - 0.11 11.7 0.0 0.2 10.9 0.0 1.4 1 1 0 1 1 1 0 Thi4 family HI0933_like PF03486.14 EMD67439.1 - 0.15 10.7 0.0 1.7 7.3 0.0 2.0 2 0 0 2 2 2 0 HI0933-like protein Glyco_hydro_106 PF17132.4 EMD67440.1 - 8.4e-39 133.5 0.9 2.7e-32 112.0 4.3 2.6 2 1 0 2 2 2 2 alpha-L-rhamnosidase HET PF06985.11 EMD67441.1 - 2.9e-30 105.5 1.7 4.8e-30 104.8 1.7 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Ank_2 PF12796.7 EMD67442.1 - 9.7e-07 29.3 0.0 2.4e-06 28.0 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EMD67442.1 - 0.00015 22.0 0.0 0.44 11.3 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.6 EMD67442.1 - 0.0013 19.0 0.0 1.3 9.5 0.0 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 EMD67442.1 - 0.0044 17.4 0.1 1.9 9.0 0.0 2.9 3 0 0 3 3 3 1 Ankyrin repeat Ank_4 PF13637.6 EMD67442.1 - 0.0094 16.5 0.1 0.11 13.1 0.1 2.6 1 1 1 2 2 2 1 Ankyrin repeats (many copies) DMT_6 PF04342.12 EMD67443.1 - 0.083 13.1 0.8 0.55 10.5 0.3 2.2 2 0 0 2 2 2 0 Putative member of DMT superfamily (DUF486) CVNH PF08881.10 EMD67444.1 - 1.8e-28 99.1 0.1 2e-28 99.0 0.1 1.0 1 0 0 1 1 1 1 CVNH domain DUF167 PF02594.16 EMD67448.1 - 0.18 11.9 0.0 0.65 10.1 0.1 1.9 2 0 0 2 2 2 0 Uncharacterised ACR, YggU family COG1872 RIX1 PF08167.12 EMD67449.1 - 2.8e-56 190.2 7.0 3.7e-56 189.8 5.1 2.2 3 0 0 3 3 3 1 rRNA processing/ribosome biogenesis IL34 PF15036.6 EMD67449.1 - 0.12 12.5 0.3 9.1 6.3 0.2 2.3 2 0 0 2 2 2 0 Interleukin 34 TPR_14 PF13428.6 EMD67450.1 - 7.7e-16 57.4 9.0 0.019 15.8 0.0 8.5 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_2 PF07719.17 EMD67450.1 - 1.7e-15 55.8 3.1 0.03 14.4 0.0 8.0 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_1 PF00515.28 EMD67450.1 - 5.5e-10 38.6 3.9 0.032 14.0 0.0 7.5 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_19 PF14559.6 EMD67450.1 - 8.3e-09 35.8 3.5 0.14 12.7 0.0 5.2 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_16 PF13432.6 EMD67450.1 - 1.7e-06 28.5 15.1 0.21 12.3 0.2 6.7 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_17 PF13431.6 EMD67450.1 - 6.5e-06 26.2 0.1 1.1 9.8 0.0 5.1 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_12 PF13424.6 EMD67450.1 - 3.1e-05 24.2 7.8 11 6.4 0.1 6.2 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_8 PF13181.6 EMD67450.1 - 0.00018 21.5 8.5 0.56 10.6 0.0 7.0 9 0 0 9 9 8 1 Tetratricopeptide repeat TPR_7 PF13176.6 EMD67450.1 - 0.014 15.4 0.7 56 4.1 0.0 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_21 PF09976.9 EMD67450.1 - 0.032 13.9 0.2 0.66 9.7 0.0 3.3 4 0 0 4 4 4 0 Tetratricopeptide repeat-like domain TPR_10 PF13374.6 EMD67450.1 - 0.19 11.7 2.7 66 3.6 0.0 4.8 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF3813 PF12758.7 EMD67450.1 - 6.9 7.1 7.5 6 7.3 0.4 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3813) p450 PF00067.22 EMD67451.1 - 3e-75 253.8 0.0 3.6e-75 253.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Epimerase PF01370.21 EMD67453.1 - 1e-08 35.0 0.0 0.0011 18.5 0.0 2.2 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.24 EMD67453.1 - 1.9e-06 28.3 0.0 4.6e-06 27.1 0.0 1.6 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain NAD_binding_10 PF13460.6 EMD67453.1 - 2.4e-06 27.6 0.0 4.1e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EMD67453.1 - 0.00013 21.6 0.0 0.00027 20.6 0.0 1.5 1 0 0 1 1 1 1 NmrA-like family NAD_binding_4 PF07993.12 EMD67453.1 - 0.0035 16.5 0.0 0.011 15.0 0.0 1.9 1 1 0 1 1 1 1 Male sterility protein DXP_reductoisom PF02670.16 EMD67453.1 - 0.031 15.0 0.0 0.077 13.7 0.0 1.7 1 0 0 1 1 1 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase Sec1 PF00995.23 EMD67454.1 - 7.7e-134 448.0 0.2 9e-134 447.8 0.2 1.0 1 0 0 1 1 1 1 Sec1 family Fungal_trans PF04082.18 EMD67455.1 - 5.5e-10 38.7 0.4 8.4e-10 38.1 0.4 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD67455.1 - 5.8e-09 35.9 7.8 1e-08 35.1 7.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Cep3 PF16846.5 EMD67455.1 - 0.0011 17.5 0.0 0.0017 16.9 0.0 1.1 1 0 0 1 1 1 1 Centromere DNA-binding protein complex CBF3 subunit B BAR PF03114.18 EMD67457.1 - 1.7e-50 171.9 8.8 2.2e-50 171.5 8.8 1.1 1 0 0 1 1 1 1 BAR domain BAR_2 PF10455.9 EMD67457.1 - 4.1e-05 22.9 3.3 5.2e-05 22.5 3.3 1.2 1 0 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking GBP_C PF02841.14 EMD67457.1 - 1.2 8.4 14.4 0.016 14.6 7.1 1.5 2 0 0 2 2 2 0 Guanylate-binding protein, C-terminal domain TMPIT PF07851.13 EMD67457.1 - 1.5 8.0 4.4 2.5 7.3 4.4 1.3 1 0 0 1 1 1 0 TMPIT-like protein OmpH PF03938.14 EMD67457.1 - 2.1 8.7 14.6 1.2 9.5 10.6 2.0 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) PRIMA1 PF16101.5 EMD67457.1 - 3.3 7.8 6.9 9.8 6.2 6.9 1.8 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 WHIM1 PF15612.6 EMD67459.1 - 0.0014 18.2 0.0 0.0027 17.2 0.0 1.4 1 0 0 1 1 1 1 WSTF, HB1, Itc1p, MBD9 motif 1 YL1 PF05764.13 EMD67459.1 - 0.35 10.9 21.6 0.033 14.3 9.6 3.1 3 0 0 3 3 3 0 YL1 nuclear protein MMM1 PF10296.9 EMD67460.1 - 6.5e-138 459.3 0.0 7.8e-138 459.0 0.0 1.1 1 0 0 1 1 1 1 Maintenance of mitochondrial morphology protein 1 adh_short PF00106.25 EMD67461.1 - 1.3e-29 103.1 0.0 1.8e-29 102.6 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD67461.1 - 5.8e-19 68.6 0.0 8e-19 68.1 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD67461.1 - 3.5e-08 33.6 0.0 5.2e-08 33.0 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EMD67461.1 - 0.00018 21.1 0.0 0.00039 20.0 0.0 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EMD67461.1 - 0.0023 17.1 0.0 0.0032 16.6 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NmrA PF05368.13 EMD67461.1 - 0.0069 16.0 0.1 0.017 14.7 0.0 1.6 2 0 0 2 2 2 1 NmrA-like family 3Beta_HSD PF01073.19 EMD67461.1 - 0.012 14.6 0.0 0.017 14.2 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 EMD67461.1 - 0.052 12.7 0.0 13 4.8 0.0 2.7 2 1 1 3 3 3 0 Male sterility protein NAD_binding_10 PF13460.6 EMD67461.1 - 0.064 13.1 0.0 0.16 11.8 0.0 1.6 2 0 0 2 2 2 0 NAD(P)H-binding DapB_N PF01113.20 EMD67461.1 - 0.086 13.0 0.0 0.14 12.3 0.0 1.4 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus WSC PF01822.19 EMD67463.1 - 6.6e-18 64.7 11.3 6.6e-18 64.7 11.3 4.1 2 1 0 3 3 3 1 WSC domain UPF0242 PF06785.11 EMD67463.1 - 4.9 7.2 11.8 7 6.7 11.8 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus PAP2 PF01569.21 EMD67464.1 - 1.5e-27 96.0 1.1 3.1e-27 95.0 1.1 1.5 1 0 0 1 1 1 1 PAP2 superfamily DUF5510 PF17629.2 EMD67464.1 - 0.19 11.6 2.7 0.37 10.8 0.1 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5510) adh_short PF00106.25 EMD67465.1 - 1.3e-34 119.3 0.5 2.9e-34 118.2 0.5 1.5 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD67465.1 - 2.4e-34 118.9 0.3 2.2e-33 115.8 0.3 1.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD67465.1 - 1.7e-10 41.1 0.0 3.7e-10 40.0 0.0 1.5 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EMD67465.1 - 0.016 14.4 0.0 0.024 13.8 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Methyltransf_23 PF13489.6 EMD67466.1 - 3.7e-14 52.9 0.0 7.1e-14 52.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMD67466.1 - 1.9e-09 38.1 0.0 5.1e-07 30.3 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMD67466.1 - 1.1e-08 35.0 0.0 3e-06 27.1 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_11 PF08241.12 EMD67466.1 - 5.9e-06 26.9 0.0 0.01 16.5 0.0 2.6 1 1 1 2 2 2 2 Methyltransferase domain Methyltransf_4 PF02390.17 EMD67466.1 - 1.7e-05 24.4 0.0 8.8e-05 22.0 0.0 2.1 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_12 PF08242.12 EMD67466.1 - 2.1e-05 25.2 0.0 0.1 13.3 0.0 2.4 1 1 0 2 2 2 2 Methyltransferase domain MTS PF05175.14 EMD67466.1 - 2.3e-05 24.0 0.0 3.9e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain FtsJ PF01728.19 EMD67466.1 - 0.00054 20.1 0.0 0.0029 17.7 0.0 2.0 2 0 0 2 2 2 1 FtsJ-like methyltransferase Methyltransf_2 PF00891.18 EMD67466.1 - 0.013 14.8 0.0 0.028 13.7 0.0 1.5 2 0 0 2 2 2 0 O-methyltransferase domain CMAS PF02353.20 EMD67466.1 - 0.091 12.0 0.0 0.15 11.3 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.18 EMD67466.1 - 0.092 12.1 0.0 0.25 10.7 0.0 1.6 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family DUF938 PF06080.12 EMD67466.1 - 0.1 12.3 0.0 0.17 11.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF938) PCMT PF01135.19 EMD67466.1 - 0.22 11.2 0.0 0.34 10.6 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) HGTP_anticodon PF03129.20 EMD67467.1 - 4.3e-22 78.1 0.4 2.5e-21 75.6 0.0 2.6 2 0 0 2 2 2 1 Anticodon binding domain tRNA-synt_2b PF00587.25 EMD67467.1 - 2e-07 31.2 0.0 5e-07 29.9 0.0 1.8 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) Brix PF04427.18 EMD67468.1 - 1e-25 90.9 0.1 2.2e-25 89.9 0.0 1.5 1 1 1 2 2 2 1 Brix domain Nop14 PF04147.12 EMD67468.1 - 0.017 13.3 23.8 0.022 13.0 23.8 1.1 1 0 0 1 1 1 0 Nop14-like family BUD22 PF09073.10 EMD67468.1 - 0.11 11.9 29.0 0.16 11.3 29.0 1.1 1 0 0 1 1 1 0 BUD22 RRN3 PF05327.11 EMD67468.1 - 0.88 8.0 6.1 1.2 7.6 6.1 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 FAD_binding_2 PF00890.24 EMD67469.1 - 0.0015 17.7 0.0 0.0016 17.6 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain CAF1 PF04857.20 EMD67470.1 - 8.7e-24 84.3 0.6 6.2e-12 45.3 0.0 3.0 3 0 0 3 3 3 2 CAF1 family ribonuclease DUF3482 PF11981.8 EMD67470.1 - 0.046 13.1 6.3 0.07 12.5 6.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3482) NDUF_B12 PF08122.12 EMD67471.1 - 1.2e-22 79.7 0.5 1.7e-22 79.2 0.5 1.2 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B12 subunit family PepSY_2 PF13670.6 EMD67473.1 - 0.18 11.8 0.1 0.24 11.5 0.1 1.1 1 0 0 1 1 1 0 Peptidase propeptide and YPEB domain PBD PF00786.28 EMD67475.1 - 0.049 14.0 0.2 0.15 12.5 0.2 1.8 1 0 0 1 1 1 0 P21-Rho-binding domain BBP1_N PF15271.6 EMD67475.1 - 5.9 7.7 8.3 3.7 8.3 0.4 3.2 3 0 0 3 3 3 0 Spindle pole body component BBP1, Mps2-binding protein Claudin_2 PF13903.6 EMD67476.1 - 0.48 10.2 1.9 1.5 8.5 1.7 1.8 1 1 1 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction tRNA-synt_His PF13393.6 EMD67477.1 - 1.6e-33 116.4 0.1 2.9e-33 115.5 0.1 1.4 1 1 0 1 1 1 1 Histidyl-tRNA synthetase tRNA-synt_2 PF00152.20 EMD67477.1 - 0.0022 17.1 0.0 0.27 10.3 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class II (D, K and N) tRNA-synt_2d PF01409.20 EMD67477.1 - 0.008 15.7 0.0 0.042 13.3 0.0 2.2 1 1 1 2 2 2 1 tRNA synthetases class II core domain (F) HGTP_anticodon PF03129.20 EMD67477.1 - 0.0089 16.2 0.1 0.029 14.5 0.0 1.8 2 0 0 2 2 2 1 Anticodon binding domain PAF-AH_p_II PF03403.13 EMD67478.1 - 9.4e-35 119.8 0.0 1.2e-32 112.9 0.0 2.1 2 0 0 2 2 2 2 Platelet-activating factor acetylhydrolase, isoform II Chlorophyllase2 PF12740.7 EMD67478.1 - 5e-10 38.7 0.1 1.9e-09 36.8 0.1 1.8 1 1 0 1 1 1 1 Chlorophyllase enzyme Chlorophyllase PF07224.11 EMD67478.1 - 3.4e-06 26.3 0.0 0.00025 20.2 0.0 2.1 2 0 0 2 2 2 2 Chlorophyllase Hydrolase_4 PF12146.8 EMD67478.1 - 0.0037 16.6 1.8 0.028 13.7 0.5 2.5 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EMD67478.1 - 0.013 16.1 0.3 0.013 16.1 0.3 2.2 1 1 0 2 2 2 0 Alpha/beta hydrolase family DUF2353 PF09789.9 EMD67479.1 - 0.047 13.0 0.0 0.071 12.5 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized coiled-coil protein (DUF2353) JAKMIP_CC3 PF16034.5 EMD67479.1 - 0.06 13.3 0.8 0.099 12.6 0.8 1.3 1 0 0 1 1 1 0 JAKMIP CC3 domain JIP_LZII PF16471.5 EMD67479.1 - 0.23 11.7 0.6 0.76 10.0 0.2 1.9 1 1 1 2 2 2 0 JNK-interacting protein leucine zipper II Aldedh PF00171.22 EMD67480.1 - 9.6e-145 482.6 0.2 1.1e-144 482.4 0.2 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 EMD67480.1 - 1.2e-05 24.9 0.1 0.0017 17.9 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF1487) Fungal_trans PF04082.18 EMD67481.1 - 2.6e-12 46.3 0.0 4.2e-12 45.7 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD67481.1 - 9.1e-08 32.1 8.2 1.4e-07 31.5 8.2 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF4091 PF13320.6 EMD67481.1 - 0.058 13.5 0.0 0.14 12.3 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4091) Ank_2 PF12796.7 EMD67482.1 - 6.2e-07 29.9 0.0 0.0012 19.3 0.1 1.8 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 EMD67482.1 - 2.3e-05 24.6 0.5 0.093 13.2 0.0 2.4 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.6 EMD67482.1 - 5.8e-05 23.2 0.1 0.031 14.8 0.0 2.7 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 EMD67482.1 - 0.0003 21.0 0.1 0.011 16.1 0.0 2.4 2 1 1 3 3 3 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 EMD67482.1 - 0.0058 17.2 0.0 1.7 9.4 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Pho88 PF10032.9 EMD67483.1 - 1.3e-81 272.2 0.0 1.5e-81 272.0 0.0 1.0 1 0 0 1 1 1 1 Phosphate transport (Pho88) DUF4512 PF14975.6 EMD67483.1 - 0.016 16.0 0.2 1.2 10.0 0.0 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4512) UCH PF00443.29 EMD67484.1 - 6e-17 62.0 0.0 1.7e-16 60.5 0.0 1.8 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EMD67484.1 - 3.2e-16 59.8 0.0 4.3e-12 46.3 0.0 3.0 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Ribosomal_L5_C PF00673.21 EMD67485.1 - 1e-26 92.9 0.0 2.1e-26 91.9 0.0 1.6 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 EMD67485.1 - 9e-13 48.3 0.1 1.8e-12 47.4 0.1 1.5 1 0 0 1 1 1 1 Ribosomal protein L5 Calpain_III PF01067.22 EMD67485.1 - 0.09 13.0 0.0 0.15 12.3 0.0 1.3 1 0 0 1 1 1 0 Calpain large subunit, domain III SIP PF04954.13 EMD67485.1 - 0.13 12.8 0.1 0.32 11.5 0.1 1.6 1 0 0 1 1 1 0 Siderophore-interacting protein CoA_binding PF02629.19 EMD67486.1 - 2.2e-27 95.6 1.6 2.2e-27 95.6 1.6 2.3 2 0 0 2 2 2 1 CoA binding domain Ligase_CoA PF00549.19 EMD67486.1 - 2.4e-24 85.9 0.3 5.3e-24 84.8 0.3 1.6 1 0 0 1 1 1 1 CoA-ligase Succ_CoA_lig PF13607.6 EMD67486.1 - 5.1e-09 36.0 0.1 9.5e-09 35.2 0.1 1.5 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.6 EMD67486.1 - 2.2e-05 24.9 0.0 8.4e-05 23.1 0.1 2.0 2 0 0 2 2 2 1 CoA binding domain DUF2431 PF10354.9 EMD67487.1 - 7.6e-59 198.8 0.0 1.6e-58 197.7 0.0 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF2431) Presenilin PF01080.17 EMD67487.1 - 0.099 11.4 2.7 1.6 7.4 0.1 2.1 2 0 0 2 2 2 0 Presenilin Peptidase_C1 PF00112.23 EMD67487.1 - 2.9 7.9 4.9 0.59 10.2 0.1 2.2 3 0 0 3 3 3 0 Papain family cysteine protease CLTH PF10607.9 EMD67488.1 - 1.8e-28 99.3 0.0 4.3e-28 98.1 0.0 1.7 2 0 0 2 2 2 1 CTLH/CRA C-terminal to LisH motif domain Adaptin_binding PF10199.9 EMD67488.1 - 0.054 14.1 0.2 0.088 13.4 0.2 1.3 1 0 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 T2SS_PulS_OutS PF09691.10 EMD67488.1 - 0.073 13.3 0.1 0.83 9.8 0.1 2.3 2 0 0 2 2 2 0 Type II secretion system pilotin lipoprotein (PulS_OutS) CheZ PF04344.13 EMD67488.1 - 0.11 12.4 0.2 0.18 11.7 0.2 1.3 1 0 0 1 1 1 0 Chemotaxis phosphatase, CheZ FUSC PF04632.12 EMD67488.1 - 0.94 7.9 4.0 1.3 7.5 4.0 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family ABC_tran PF00005.27 EMD67489.1 - 1.1e-46 158.8 0.1 2.1e-23 83.3 0.0 2.9 3 0 0 3 3 2 2 ABC transporter ABC_tran_Xtn PF12848.7 EMD67489.1 - 2.3e-21 75.6 3.2 2.3e-21 75.6 3.2 2.5 3 0 0 3 3 2 1 ABC transporter AAA_21 PF13304.6 EMD67489.1 - 5.9e-18 65.7 0.4 0.00091 19.1 0.0 4.3 3 1 0 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EMD67489.1 - 2.9e-09 36.7 1.1 0.44 9.9 0.0 4.3 3 1 0 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EMD67489.1 - 2.3e-08 33.7 0.2 0.0023 17.6 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_23 PF13476.6 EMD67489.1 - 6.1e-08 33.4 7.4 0.014 15.9 0.1 3.9 4 0 0 4 4 4 2 AAA domain RsgA_GTPase PF03193.16 EMD67489.1 - 4.4e-07 30.0 0.2 0.00034 20.6 0.0 2.9 3 0 0 3 3 3 1 RsgA GTPase AAA_15 PF13175.6 EMD67489.1 - 9.8e-07 28.8 5.5 0.022 14.5 0.0 3.8 4 1 0 4 4 4 2 AAA ATPase domain AAA_16 PF13191.6 EMD67489.1 - 2.3e-06 28.1 0.0 0.013 15.9 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain AAA_28 PF13521.6 EMD67489.1 - 1.3e-05 25.5 0.0 0.0073 16.6 0.0 2.8 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EMD67489.1 - 2.4e-05 24.9 0.0 0.24 11.9 0.0 3.0 3 0 0 3 3 2 2 AAA domain MMR_HSR1 PF01926.23 EMD67489.1 - 7.6e-05 22.8 0.0 0.015 15.3 0.0 2.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_22 PF13401.6 EMD67489.1 - 0.00015 22.0 0.0 0.44 10.8 0.0 2.6 2 0 0 2 2 2 2 AAA domain NACHT PF05729.12 EMD67489.1 - 0.00021 21.3 0.1 0.24 11.3 0.0 2.6 2 0 0 2 2 2 2 NACHT domain AAA_27 PF13514.6 EMD67489.1 - 0.00025 20.7 0.0 0.14 11.7 0.0 2.7 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 EMD67489.1 - 0.00025 21.4 0.7 1.2 9.6 0.0 3.4 3 0 0 3 3 3 1 RNA helicase AAA PF00004.29 EMD67489.1 - 0.00028 21.3 0.0 0.56 10.6 0.0 2.8 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) Roc PF08477.13 EMD67489.1 - 0.00056 20.1 0.1 1.7 8.8 0.1 2.9 2 1 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase NB-ARC PF00931.22 EMD67489.1 - 0.00071 18.8 0.1 3.3 6.8 0.0 3.4 3 0 0 3 3 3 2 NB-ARC domain AAA_24 PF13479.6 EMD67489.1 - 0.0015 18.3 1.1 2.4 7.9 0.0 3.2 3 0 0 3 3 3 2 AAA domain AAA_5 PF07728.14 EMD67489.1 - 0.0039 17.2 0.1 3.7 7.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 EMD67489.1 - 0.0054 16.8 0.1 6.7 6.8 0.0 3.0 3 0 0 3 3 2 0 AAA domain PduV-EutP PF10662.9 EMD67489.1 - 0.0065 16.2 0.5 0.31 10.8 0.0 3.0 3 0 0 3 3 3 1 Ethanolamine utilisation - propanediol utilisation AAA_33 PF13671.6 EMD67489.1 - 0.008 16.3 0.4 3 8.0 0.0 3.0 3 0 0 3 3 2 1 AAA domain Ras PF00071.22 EMD67489.1 - 0.0098 15.5 0.3 3.4 7.2 0.0 2.7 3 0 0 3 3 3 1 Ras family AAA_25 PF13481.6 EMD67489.1 - 0.016 14.8 0.1 1.3 8.5 0.0 3.5 3 1 0 3 3 3 0 AAA domain AAA_7 PF12775.7 EMD67489.1 - 0.018 14.6 0.0 1.2 8.6 0.0 2.5 2 0 0 2 2 2 0 P-loop containing dynein motor region FeoB_N PF02421.18 EMD67489.1 - 0.018 14.5 0.2 1.5 8.3 0.0 2.9 3 0 0 3 3 3 0 Ferrous iron transport protein B Dynamin_N PF00350.23 EMD67489.1 - 0.028 14.5 0.9 1.3 9.1 0.0 3.4 3 1 1 4 4 4 0 Dynamin family ATPase_2 PF01637.18 EMD67489.1 - 0.031 14.2 0.1 5.4 6.9 0.0 2.8 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea AAA_30 PF13604.6 EMD67489.1 - 0.052 13.3 0.1 9.3 5.9 0.0 2.8 2 1 0 2 2 2 0 AAA domain AAA_17 PF13207.6 EMD67489.1 - 0.091 13.2 0.2 13 6.2 0.0 3.1 3 0 0 3 3 2 0 AAA domain TsaE PF02367.17 EMD67489.1 - 0.11 12.5 0.1 20 5.2 0.0 2.9 3 0 0 3 3 3 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NTPase_1 PF03266.15 EMD67489.1 - 0.12 12.2 0.5 8.3 6.3 0.1 2.6 2 0 0 2 2 2 0 NTPase cobW PF02492.19 EMD67489.1 - 0.88 9.1 3.2 22 4.6 0.3 2.8 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain AAA_13 PF13166.6 EMD67489.1 - 2.4 6.7 9.4 10 4.6 0.0 4.3 4 1 0 4 4 4 0 AAA domain HPP PF04982.13 EMD67490.1 - 9e-38 129.2 5.0 9e-38 129.2 5.0 1.9 2 0 0 2 2 2 1 HPP family SNF2_N PF00176.23 EMD67491.1 - 9.7e-53 179.1 0.1 3.4e-51 174.0 0.1 2.5 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EMD67491.1 - 1.1e-16 61.2 0.0 1.4e-15 57.6 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain zf-C3HC4 PF00097.25 EMD67491.1 - 2.1e-05 24.3 10.9 2.1e-05 24.3 10.9 2.0 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) AAA_34 PF13872.6 EMD67491.1 - 0.00011 21.2 0.0 0.00025 20.0 0.0 1.5 1 0 0 1 1 1 1 P-loop containing NTP hydrolase pore-1 DEAD PF00270.29 EMD67491.1 - 0.0047 16.7 0.0 0.01 15.6 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase zf-C3HC4_3 PF13920.6 EMD67491.1 - 0.0087 15.9 9.9 0.0087 15.9 9.9 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) DRAT PF07357.11 EMD67491.1 - 0.011 14.9 0.0 0.021 14.0 0.0 1.4 1 0 0 1 1 1 0 Dinitrogenase reductase ADP-ribosyltransferase (DRAT) ERCC3_RAD25_C PF16203.5 EMD67491.1 - 0.041 13.1 0.0 0.041 13.1 0.0 1.8 2 0 0 2 2 1 0 ERCC3/RAD25/XPB C-terminal helicase zf-rbx1 PF12678.7 EMD67491.1 - 0.25 11.7 7.8 0.72 10.2 7.8 1.8 1 0 0 1 1 1 0 RING-H2 zinc finger domain Zn_Tnp_IS91 PF14319.6 EMD67491.1 - 0.57 10.2 13.8 1.4 9.0 1.2 2.7 2 0 0 2 2 2 0 Transposase zinc-binding domain zf-RING_5 PF14634.6 EMD67491.1 - 7.2 6.7 23.0 0.052 13.5 11.2 2.4 2 0 0 2 2 2 0 zinc-RING finger domain zf-RING_2 PF13639.6 EMD67491.1 - 9.2 6.7 24.7 0.031 14.6 11.9 2.5 2 0 0 2 2 2 0 Ring finger domain zf-RING_UBOX PF13445.6 EMD67491.1 - 9.3 6.4 17.9 0.083 12.9 9.3 2.1 2 0 0 2 2 2 0 RING-type zinc-finger Pkinase PF00069.25 EMD67492.1 - 0.028 13.8 0.0 0.15 11.4 0.0 2.0 1 1 0 1 1 1 0 Protein kinase domain DUF2892 PF11127.8 EMD67494.1 - 0.0019 18.2 0.9 0.0033 17.4 0.9 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF2892) Radical_SAM_C PF16199.5 EMD67495.1 - 1.5e-32 111.4 0.1 4.9e-32 109.8 0.0 1.9 2 0 0 2 2 2 1 Radical_SAM C-terminal domain Radical_SAM PF04055.21 EMD67495.1 - 1.4e-18 67.9 0.1 5e-18 66.0 0.0 1.9 2 0 0 2 2 2 1 Radical SAM superfamily Acetyltransf_1 PF00583.25 EMD67495.1 - 1.5e-09 38.1 0.0 3.4e-09 37.0 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EMD67495.1 - 1.2e-06 28.4 0.1 1.1e-05 25.4 0.0 2.2 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EMD67495.1 - 0.027 14.9 0.1 0.074 13.5 0.1 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acyltransferase PF01553.21 EMD67496.1 - 1.2e-29 102.6 0.0 2.2e-29 101.8 0.0 1.4 1 0 0 1 1 1 1 Acyltransferase Acyltransf_C PF16076.5 EMD67496.1 - 9.5e-14 51.3 0.0 2e-13 50.2 0.0 1.5 1 0 0 1 1 1 1 Acyltransferase C-terminus NAD_kinase PF01513.21 EMD67497.1 - 1.9e-51 175.0 0.0 2.9e-51 174.4 0.0 1.2 1 0 0 1 1 1 1 ATP-NAD kinase DAGK_cat PF00781.24 EMD67497.1 - 0.035 13.7 0.0 0.066 12.8 0.0 1.4 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain Rit1_C PF17184.4 EMD67498.1 - 9.3e-105 350.0 0.0 1.5e-104 349.3 0.0 1.3 1 0 0 1 1 1 1 Rit1 N-terminal domain Init_tRNA_PT PF04179.12 EMD67498.1 - 4.5e-33 113.8 0.0 8.6e-33 112.9 0.0 1.5 1 0 0 1 1 1 1 Rit1 DUSP-like domain Glyco_hydro_6 PF01341.17 EMD67499.1 - 5.8e-100 335.0 0.3 7.2e-100 334.7 0.3 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 6 MFS_2 PF13347.6 EMD67500.1 - 3.3e-14 52.3 14.8 6e-12 44.8 6.2 3.7 4 0 0 4 4 4 3 MFS/sugar transport protein PUCC PF03209.15 EMD67500.1 - 0.00022 20.3 2.6 0.00022 20.3 2.6 2.0 2 0 0 2 2 2 1 PUCC protein Na_H_Exchanger PF00999.21 EMD67501.1 - 5.1e-75 252.6 34.3 6.3e-75 252.3 34.3 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family NiFe_hyd_3_EhaA PF17367.2 EMD67501.1 - 0.55 10.4 18.1 0.92 9.7 0.8 4.1 3 1 2 5 5 5 0 NiFe-hydrogenase-type-3 Eha complex subunit A TRAPP PF04051.16 EMD67502.1 - 9.1e-41 139.0 0.0 1.2e-40 138.6 0.0 1.2 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Poty_PP PF08440.10 EMD67503.1 - 0.036 13.2 0.0 0.053 12.6 0.0 1.2 1 0 0 1 1 1 0 Potyviridae polyprotein Ldh_1_N PF00056.23 EMD67504.1 - 5.5e-46 156.2 0.2 7.6e-46 155.7 0.2 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 EMD67504.1 - 9.9e-45 152.5 0.0 1.6e-44 151.8 0.0 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain 3Beta_HSD PF01073.19 EMD67504.1 - 1.5e-05 24.1 0.0 2.3e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 EMD67504.1 - 0.00027 20.9 0.0 0.00067 19.6 0.0 1.6 2 0 0 2 2 2 1 NAD(P)H-binding THF_DHG_CYH_C PF02882.19 EMD67504.1 - 0.028 13.8 0.2 0.3 10.4 0.2 2.3 1 1 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Glyco_hydro_4 PF02056.16 EMD67504.1 - 0.11 12.0 0.1 5.6 6.5 0.1 2.2 1 1 1 2 2 2 0 Family 4 glycosyl hydrolase CBFD_NFYB_HMF PF00808.23 EMD67505.1 - 3.3e-19 68.9 0.5 4.7e-19 68.4 0.5 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EMD67505.1 - 1e-14 55.0 0.2 1.7e-14 54.3 0.2 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-X PF09415.10 EMD67505.1 - 0.047 14.0 0.2 0.099 13.0 0.0 1.6 2 0 0 2 2 2 0 CENP-S associating Centromere protein X Fcf2 PF08698.11 EMD67506.1 - 4e-38 129.7 0.8 4e-38 129.7 0.8 2.0 2 0 0 2 2 2 1 Fcf2 pre-rRNA processing FKBP_N PF01346.18 EMD67506.1 - 3 8.9 10.5 2.9 8.9 0.1 3.1 3 0 0 3 3 3 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase PNP_UDP_1 PF01048.20 EMD67507.1 - 1.5e-56 191.3 0.5 2e-56 190.9 0.5 1.2 1 0 0 1 1 1 1 Phosphorylase superfamily Ribosomal_S10 PF00338.22 EMD67508.1 - 1.3e-23 83.0 0.0 4.6e-23 81.3 0.0 1.9 2 0 0 2 2 2 1 Ribosomal protein S10p/S20e Glyco_hydro_31 PF01055.26 EMD67509.1 - 4.7e-95 319.4 6.2 7.7e-95 318.7 6.2 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 DUF5110 PF17137.4 EMD67509.1 - 2.5e-06 27.7 0.0 2.6e-05 24.4 0.0 2.6 1 1 0 1 1 1 1 Domain of unknown function (DUF5110) DUF4968 PF16338.5 EMD67509.1 - 0.0011 19.2 0.0 0.0026 18.0 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4968) Glycos_transf_1 PF00534.20 EMD67510.1 - 3.3e-20 72.3 0.0 8.4e-20 71.0 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EMD67510.1 - 7.7e-14 52.3 0.0 2.1e-13 50.9 0.0 1.8 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 EMD67510.1 - 0.00017 21.9 0.0 0.00041 20.7 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 WD40 PF00400.32 EMD67511.1 - 3.6e-57 189.0 15.1 1.1e-08 35.6 0.4 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD67511.1 - 3e-16 59.5 0.1 0.0012 19.1 0.0 5.3 1 1 6 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain Tup_N PF08581.10 EMD67511.1 - 4e-16 59.1 7.8 7.4e-16 58.2 7.8 1.5 1 0 0 1 1 1 1 Tup N-terminal WD40_like PF17005.5 EMD67511.1 - 2.9e-09 36.7 0.0 0.013 14.8 0.0 4.7 3 1 2 5 5 5 2 WD40-like domain Nup160 PF11715.8 EMD67511.1 - 5.7e-05 21.9 0.5 0.12 11.0 0.0 3.7 1 1 3 4 4 4 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 EMD67511.1 - 0.00037 19.5 0.1 2.6 6.9 0.0 4.2 1 1 3 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Nucleoporin_N PF08801.11 EMD67511.1 - 0.024 13.4 0.2 26 3.4 0.0 3.5 2 1 1 3 3 3 0 Nup133 N terminal like Golgin_A5 PF09787.9 EMD67511.1 - 0.04 13.4 2.8 0.058 12.9 2.8 1.1 1 0 0 1 1 1 0 Golgin subfamily A member 5 Nuc_N PF14448.6 EMD67511.1 - 0.055 13.3 0.1 0.15 11.9 0.1 1.8 1 0 0 1 1 1 0 Nuclease N terminal Nbas_N PF15492.6 EMD67511.1 - 0.14 11.5 0.1 11 5.2 0.0 2.8 1 1 1 3 3 3 0 Neuroblastoma-amplified sequence, N terminal BBP1_C PF15272.6 EMD67511.1 - 0.15 11.9 1.5 0.23 11.3 1.5 1.2 1 0 0 1 1 1 0 Spindle pole body component BBP1, C-terminal BicD PF09730.9 EMD67511.1 - 0.16 10.4 1.0 0.22 9.9 1.0 1.1 1 0 0 1 1 1 0 Microtubule-associated protein Bicaudal-D PALB2_WD40 PF16756.5 EMD67511.1 - 0.17 10.8 0.0 0.31 9.9 0.0 1.4 1 0 0 1 1 1 0 Partner and localizer of BRCA2 WD40 domain ZapB PF06005.12 EMD67511.1 - 0.21 12.0 1.8 0.48 10.9 1.8 1.5 1 0 0 1 1 1 0 Cell division protein ZapB CLZ PF16526.5 EMD67511.1 - 0.72 10.2 3.3 1.2 9.5 3.3 1.4 1 0 0 1 1 1 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Pro-rich PF15240.6 EMD67511.1 - 9.3 6.5 60.8 16 5.7 60.8 1.3 1 0 0 1 1 1 0 Proline-rich PI3K_P85_iSH2 PF16454.5 EMD67512.1 - 0.006 16.2 1.6 0.012 15.2 1.6 1.4 1 0 0 1 1 1 1 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain DUF4201 PF13870.6 EMD67512.1 - 0.0093 15.7 1.4 0.019 14.7 1.4 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4201) DUF4200 PF13863.6 EMD67512.1 - 0.018 15.4 2.7 0.038 14.4 2.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) DUF724 PF05266.14 EMD67512.1 - 0.038 13.8 3.4 0.031 14.1 1.6 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF724) DUF600 PF04634.12 EMD67512.1 - 0.1 12.6 0.2 0.41 10.7 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function, DUF600 DUF1829 PF08862.10 EMD67512.1 - 0.25 11.9 2.3 0.4 11.2 0.8 2.1 2 1 0 2 2 2 0 Domain of unknown function DUF1829 Nsp1_C PF05064.13 EMD67512.1 - 0.26 11.1 3.0 2.7 7.8 2.7 2.4 2 1 0 2 2 2 0 Nsp1-like C-terminal region Seryl_tRNA_N PF02403.22 EMD67512.1 - 0.38 11.0 4.8 0.6 10.4 2.1 2.3 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Osmo_CC PF08946.10 EMD67512.1 - 3.3 8.0 6.2 51 4.2 6.2 2.5 1 1 0 1 1 1 0 Osmosensory transporter coiled coil APG6_N PF17675.1 EMD67512.1 - 5.4 7.5 9.9 4 8.0 7.4 2.2 2 1 0 2 2 2 0 Apg6 coiled-coil region Pkinase PF00069.25 EMD67513.1 - 2.4e-07 30.4 0.0 3.6e-07 29.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Peptidase_M13_N PF05649.13 EMD67514.1 - 3e-101 339.9 0.0 3.9e-101 339.5 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M13 Peptidase_M13 PF01431.21 EMD67514.1 - 1.8e-62 210.6 0.5 1e-61 208.2 0.1 2.1 2 0 0 2 2 2 1 Peptidase family M13 Abhydrolase_3 PF07859.13 EMD67515.1 - 2.4e-48 164.8 0.0 3.4e-48 164.3 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 EMD67515.1 - 2e-15 56.7 0.1 8e-15 54.7 0.1 1.9 2 1 0 2 2 2 1 Carboxylesterase family Peptidase_S9 PF00326.21 EMD67515.1 - 0.0036 16.8 0.0 0.16 11.5 0.0 2.3 2 0 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 EMD67515.1 - 0.013 16.2 0.0 0.018 15.7 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family Esterase_phd PF10503.9 EMD67515.1 - 0.081 12.4 0.0 0.13 11.7 0.0 1.2 1 0 0 1 1 1 0 Esterase PHB depolymerase Say1_Mug180 PF10340.9 EMD67515.1 - 0.17 10.7 0.1 0.33 9.8 0.1 1.6 1 1 0 1 1 1 0 Steryl acetyl hydrolase Abhydrolase_1 PF00561.20 EMD67516.1 - 4.8e-24 85.4 0.1 2.8e-23 82.9 0.1 1.9 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EMD67516.1 - 3.2e-18 67.2 0.1 4e-18 66.8 0.1 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EMD67516.1 - 6.7e-18 64.8 0.2 3.7e-17 62.4 0.2 1.9 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Chlorophyllase PF07224.11 EMD67516.1 - 1.9e-06 27.1 0.0 3.1e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 Chlorophyllase DLH PF01738.18 EMD67516.1 - 5.1e-05 22.9 0.0 0.17 11.4 0.0 2.9 2 1 0 2 2 2 2 Dienelactone hydrolase family Thioesterase PF00975.20 EMD67516.1 - 0.00011 22.4 0.0 0.00017 21.8 0.0 1.3 1 1 0 1 1 1 1 Thioesterase domain DUF1057 PF06342.12 EMD67516.1 - 0.00041 19.5 0.0 0.00063 18.9 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1057) Abhydrolase_3 PF07859.13 EMD67516.1 - 0.0011 18.9 0.1 0.068 13.0 0.0 2.3 2 0 0 2 2 2 1 alpha/beta hydrolase fold Esterase PF00756.20 EMD67516.1 - 0.0014 18.3 0.0 0.0025 17.5 0.0 1.4 1 0 0 1 1 1 1 Putative esterase Chlorophyllase2 PF12740.7 EMD67516.1 - 0.0021 17.0 0.0 0.003 16.5 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase enzyme DUF915 PF06028.11 EMD67516.1 - 0.082 12.2 0.1 0.81 9.0 0.1 2.1 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF915) Pro_CA PF00484.19 EMD67517.1 - 1.1e-12 48.6 0.6 1.2e-11 45.1 0.6 2.0 1 1 0 1 1 1 1 Carbonic anhydrase GreA_GreB PF01272.19 EMD67517.1 - 0.15 12.0 0.0 0.59 10.1 0.0 1.9 2 0 0 2 2 2 0 Transcription elongation factor, GreA/GreB, C-term TPR_10 PF13374.6 EMD67518.1 - 5.9e-86 280.3 12.8 4e-13 48.8 0.0 8.3 8 0 0 8 8 7 7 Tetratricopeptide repeat TPR_12 PF13424.6 EMD67518.1 - 9.5e-57 189.2 8.7 9.7e-15 54.6 0.1 7.7 1 1 6 7 7 7 7 Tetratricopeptide repeat TPR_7 PF13176.6 EMD67518.1 - 5.4e-22 76.2 6.8 0.011 15.7 0.0 8.0 7 0 0 7 7 7 5 Tetratricopeptide repeat NB-ARC PF00931.22 EMD67518.1 - 5.3e-15 55.3 0.0 1.1e-14 54.2 0.0 1.6 1 0 0 1 1 1 1 NB-ARC domain TPR_17 PF13431.6 EMD67518.1 - 4.6e-13 48.6 3.2 0.71 10.4 0.0 7.9 8 0 0 8 8 8 3 Tetratricopeptide repeat HET PF06985.11 EMD67518.1 - 3.9e-12 46.8 11.4 3.7e-10 40.3 3.9 3.5 2 1 1 3 3 3 2 Heterokaryon incompatibility protein (HET) AAA_16 PF13191.6 EMD67518.1 - 2e-11 44.6 0.5 3.2e-09 37.4 0.0 2.7 2 0 0 2 2 2 1 AAA ATPase domain TPR_19 PF14559.6 EMD67518.1 - 2.3e-11 44.0 0.7 0.31 11.6 0.1 6.9 3 1 4 7 7 6 1 Tetratricopeptide repeat TPR_MalT PF17874.1 EMD67518.1 - 2.6e-11 43.5 11.9 1.6e-07 31.1 2.7 3.1 1 1 2 3 3 3 3 MalT-like TPR region TPR_2 PF07719.17 EMD67518.1 - 1.2e-10 40.6 13.0 2.9 8.2 0.0 8.3 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_1 PF00515.28 EMD67518.1 - 6.7e-10 38.4 7.2 1.2 9.1 0.0 7.8 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_16 PF13432.6 EMD67518.1 - 4.4e-08 33.6 0.1 24 5.7 0.0 7.5 7 1 0 7 7 7 0 Tetratricopeptide repeat TPR_4 PF07721.14 EMD67518.1 - 4.5e-08 33.0 0.1 54 4.9 0.0 7.3 7 0 0 7 7 6 0 Tetratricopeptide repeat AAA_22 PF13401.6 EMD67518.1 - 7.5e-06 26.3 0.0 3.6e-05 24.1 0.0 2.2 1 0 0 1 1 1 1 AAA domain TPR_3 PF07720.12 EMD67518.1 - 2.8e-05 24.0 0.8 0.15 12.1 0.6 5.2 6 0 0 6 6 5 1 Tetratricopeptide repeat A2M PF00207.22 EMD67518.1 - 8.5e-05 22.3 1.0 2.4 8.1 0.0 4.7 1 1 4 5 5 5 1 Alpha-2-macroglobulin family TniB PF05621.11 EMD67518.1 - 0.00023 20.6 0.0 0.0008 18.9 0.0 2.0 1 0 0 1 1 1 1 Bacterial TniB protein ATPase_2 PF01637.18 EMD67518.1 - 0.00041 20.3 0.0 0.00087 19.3 0.0 1.6 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea NACHT PF05729.12 EMD67518.1 - 0.0006 19.8 0.1 0.002 18.1 0.1 2.0 1 0 0 1 1 1 1 NACHT domain CutA1 PF03091.15 EMD67518.1 - 0.00066 19.5 10.9 5.6 6.9 0.0 6.4 2 1 2 5 5 5 1 CutA1 divalent ion tolerance protein AAA PF00004.29 EMD67518.1 - 0.001 19.5 0.0 0.0045 17.4 0.0 2.2 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.17 EMD67518.1 - 0.0019 18.0 0.0 0.0041 16.9 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein DnaB_C PF03796.15 EMD67518.1 - 0.0043 16.4 0.0 0.016 14.5 0.0 1.9 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain TPR_8 PF13181.6 EMD67518.1 - 0.0043 17.2 8.4 15 6.1 0.0 6.8 8 0 0 8 8 6 0 Tetratricopeptide repeat PPR PF01535.20 EMD67518.1 - 0.0051 17.0 1.6 2e+02 2.6 0.0 5.7 6 0 0 6 6 5 0 PPR repeat DUF3157 PF11355.8 EMD67518.1 - 0.017 14.7 4.0 1.7 8.2 0.1 3.1 1 1 3 4 4 4 0 Protein of unknown function (DUF3157) zf-Mss51 PF13824.6 EMD67518.1 - 0.038 14.1 0.2 1.4e+02 2.7 0.0 5.0 5 0 0 5 5 5 0 Zinc-finger of mitochondrial splicing suppressor 51 DUF1897 PF09005.10 EMD67518.1 - 0.52 9.8 9.3 21 4.7 0.1 4.5 5 0 0 5 5 5 0 Domain of unknown function (DUF1897) TPR_14 PF13428.6 EMD67518.1 - 5.1 8.2 11.7 3.3e+02 2.5 0.1 7.2 9 0 0 9 9 6 0 Tetratricopeptide repeat F-box-like PF12937.7 EMD67519.1 - 0.0001 22.1 0.2 0.00039 20.3 0.1 2.1 2 0 0 2 2 2 1 F-box-like LRR_4 PF12799.7 EMD67519.1 - 1.9 9.0 7.9 50 4.5 0.0 5.5 7 0 0 7 7 7 0 Leucine Rich repeats (2 copies) Glyco_transf_8 PF01501.20 EMD67521.1 - 1.3e-14 54.4 0.2 2.6e-14 53.4 0.2 1.5 1 1 0 1 1 1 1 Glycosyl transferase family 8 Nucleotid_trans PF03407.16 EMD67521.1 - 0.015 15.3 0.6 0.035 14.1 0.6 1.6 1 1 0 1 1 1 0 Nucleotide-diphospho-sugar transferase Peroxin-3 PF04882.12 EMD67522.1 - 2.2e-167 557.8 0.0 2.6e-167 557.6 0.0 1.0 1 0 0 1 1 1 1 Peroxin-3 DGCR6 PF07324.11 EMD67522.1 - 0.097 12.3 0.1 0.17 11.5 0.1 1.3 1 0 0 1 1 1 0 DiGeorge syndrome critical region 6 (DGCR6) protein DHC PF09626.10 EMD67523.1 - 0.16 12.9 1.4 18 6.3 0.1 2.1 2 0 0 2 2 2 0 Dihaem cytochrome c Pkinase PF00069.25 EMD67524.1 - 2.5e-35 122.1 0.0 3e-35 121.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD67524.1 - 1.5e-21 76.8 0.0 1.8e-21 76.6 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase SatRNA_48 PF17485.2 EMD67524.1 - 0.0027 16.9 0.0 0.0037 16.4 0.0 1.1 1 0 0 1 1 1 1 Satellite RNA 48 kDa protein APH PF01636.23 EMD67524.1 - 0.017 15.0 0.0 0.02 14.8 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Mgm101p PF06420.12 EMD67524.1 - 0.1 12.1 0.0 0.15 11.6 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial genome maintenance MGM101 zf-CCHC PF00098.23 EMD67525.1 - 8.1e-30 101.6 42.2 8.8e-07 28.7 0.3 7.2 3 1 4 7 7 7 7 Zinc knuckle zf-CCHC_4 PF14392.6 EMD67525.1 - 8.8e-09 35.0 35.6 0.0025 17.5 0.7 6.7 1 1 6 7 7 7 6 Zinc knuckle zf-CCHC_6 PF15288.6 EMD67525.1 - 9.9e-05 22.1 44.5 0.074 12.9 1.8 6.9 2 2 5 7 7 7 6 Zinc knuckle zf-CCHC_3 PF13917.6 EMD67525.1 - 0.57 10.2 30.7 14 5.7 0.0 5.2 1 1 3 4 4 4 0 Zinc knuckle GMC_oxred_C PF05199.13 EMD67526.1 - 2.3e-15 57.4 0.1 3.6e-15 56.7 0.1 1.3 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_N PF00732.19 EMD67526.1 - 6.5e-06 25.7 0.0 1.6e-05 24.5 0.0 1.6 1 1 0 1 1 1 1 GMC oxidoreductase DUF1659 PF07872.11 EMD67526.1 - 0.084 12.5 0.1 5.2 6.8 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1659) TB2_DP1_HVA22 PF03134.19 EMD67527.1 - 5e-21 74.4 10.0 5e-21 74.4 10.0 2.0 1 1 1 2 2 2 2 TB2/DP1, HVA22 family FA_desaturase PF00487.24 EMD67527.1 - 0.15 11.9 6.0 0.19 11.6 6.0 1.2 1 0 0 1 1 1 0 Fatty acid desaturase RFX_DNA_binding PF02257.15 EMD67528.1 - 1.2e-27 96.4 0.0 2.9e-27 95.1 0.0 1.7 1 0 0 1 1 1 1 RFX DNA-binding domain RXLR PF16810.5 EMD67528.1 - 0.057 13.8 0.8 0.54 10.7 0.0 2.2 2 0 0 2 2 2 0 RXLR phytopathogen effector protein, Avirulence activity Cellulase PF00150.18 EMD67529.1 - 3.1e-19 69.5 2.3 4.6e-19 68.9 2.3 1.1 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Cu_amine_oxid PF01179.20 EMD67530.1 - 3.7e-159 530.0 0.0 4.9e-159 529.6 0.0 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Mito_carr PF00153.27 EMD67530.1 - 1.9e-59 197.6 0.1 2e-19 69.3 0.0 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein Cu_amine_oxidN3 PF02728.16 EMD67530.1 - 4.7e-20 71.9 0.1 8.7e-20 71.0 0.1 1.5 1 0 0 1 1 1 1 Copper amine oxidase, N3 domain Cu_amine_oxidN2 PF02727.16 EMD67530.1 - 1.5e-10 41.2 0.0 2.6e-10 40.4 0.0 1.4 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain TPR_2 PF07719.17 EMD67531.1 - 1.3e-08 34.3 2.6 0.00045 20.1 0.1 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 EMD67531.1 - 1.6e-06 27.7 2.2 0.02 14.7 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 EMD67531.1 - 2e-06 28.0 0.6 0.0058 16.9 0.1 2.8 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 EMD67531.1 - 2.2e-06 27.4 0.1 0.0071 16.5 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.6 EMD67531.1 - 2.5e-05 24.8 1.8 0.015 15.9 0.1 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 EMD67531.1 - 0.0003 21.2 0.4 0.0031 18.0 0.0 2.3 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 EMD67531.1 - 0.001 19.7 3.5 0.13 13.2 0.1 2.7 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_MalT PF17874.1 EMD67531.1 - 0.027 13.9 1.4 0.042 13.2 1.4 1.3 1 1 0 1 1 1 0 MalT-like TPR region TPR_4 PF07721.14 EMD67531.1 - 0.083 13.6 1.9 0.8 10.5 0.1 3.2 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 EMD67531.1 - 0.11 12.6 0.0 16 5.8 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 EMD67531.1 - 0.33 11.7 1.8 7.2 7.5 0.0 2.7 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_10 PF13374.6 EMD67531.1 - 2.9 7.9 6.5 16 5.5 0.0 3.3 4 0 0 4 4 4 0 Tetratricopeptide repeat MARVEL PF01284.23 EMD67532.1 - 1.4e-06 28.4 12.5 2.1e-06 27.8 12.5 1.2 1 0 0 1 1 1 1 Membrane-associating domain NCE101 PF11654.8 EMD67532.1 - 0.11 12.2 0.1 0.26 11.0 0.1 1.6 1 0 0 1 1 1 0 Non-classical export protein 1 GST_N_2 PF13409.6 EMD67533.1 - 5.1e-18 65.1 0.0 1.1e-17 64.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EMD67533.1 - 7.1e-13 48.4 0.0 2.3e-12 46.8 0.1 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EMD67533.1 - 0.00014 22.0 0.0 0.00023 21.3 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EMD67533.1 - 0.0028 18.0 0.0 0.026 14.9 0.0 2.2 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EMD67533.1 - 0.071 13.3 0.1 0.14 12.4 0.1 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain DUF5527 PF17665.1 EMD67534.1 - 0.0003 20.3 1.7 0.00063 19.3 1.7 1.5 1 0 0 1 1 1 1 Family of unknown function (DUF5527) Abhydrolase_9_N PF15420.6 EMD67534.1 - 0.93 9.5 10.9 3.5 7.6 4.4 2.2 2 0 0 2 2 2 0 Alpha/beta-hydrolase family N-terminus RhodobacterPufX PF11511.8 EMD67534.1 - 9.7 5.9 7.0 1.1 8.9 1.6 2.2 2 0 0 2 2 2 0 Intrinsic membrane protein PufX FAD_binding_4 PF01565.23 EMD67535.1 - 2.5e-16 59.7 4.9 2.8e-16 59.5 2.5 2.2 2 0 0 2 2 2 1 FAD binding domain BBE PF08031.12 EMD67535.1 - 8e-11 41.9 0.2 1.8e-10 40.7 0.2 1.6 1 0 0 1 1 1 1 Berberine and berberine like DUF3552 PF12072.8 EMD67536.1 - 4.4e-05 23.0 12.0 4.4e-05 23.0 12.0 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF3552) Gly-zipper_YMGG PF13441.6 EMD67536.1 - 8.5 6.2 25.4 1.6e+02 2.1 25.4 2.5 1 1 0 1 1 1 0 YMGG-like Gly-zipper DUF4337 PF14235.6 EMD67536.1 - 8.5 6.5 11.1 15 5.6 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4337) Ubiquitin_5 PF18037.1 EMD67537.1 - 0.0093 16.3 0.2 0.43 11.0 0.3 2.9 3 0 0 3 3 3 1 Ubiquitin-like domain FapA PF03961.13 EMD67537.1 - 0.034 12.8 7.8 0.072 11.7 7.8 1.5 1 0 0 1 1 1 0 Flagellar Assembly Protein A UPF0242 PF06785.11 EMD67537.1 - 0.32 11.1 20.4 0.045 13.9 15.6 1.9 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Fib_alpha PF08702.10 EMD67537.1 - 1 9.6 5.8 3.2 7.9 2.6 2.7 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family OmpH PF03938.14 EMD67537.1 - 2.7 8.3 10.2 0.22 11.9 3.9 2.4 3 0 0 3 3 3 0 Outer membrane protein (OmpH-like) Lipase_chap PF03280.14 EMD67537.1 - 3.1 7.7 12.5 1.5 8.8 9.1 2.1 2 0 0 2 2 2 0 Proteobacterial lipase chaperone protein DUF4407 PF14362.6 EMD67537.1 - 4.5 6.5 9.5 2 7.7 7.2 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) TPR_MLP1_2 PF07926.12 EMD67538.1 - 0.0024 17.9 3.3 0.0024 17.9 3.3 1.6 2 0 0 2 2 2 1 TPR/MLP1/MLP2-like protein GAS PF13851.6 EMD67538.1 - 0.0058 16.0 2.5 0.0098 15.3 2.5 1.3 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding DUF5595 PF18077.1 EMD67538.1 - 0.13 12.4 1.0 0.25 11.4 1.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5595) DivIC PF04977.15 EMD67538.1 - 0.44 10.4 4.9 0.059 13.2 0.7 1.7 2 0 0 2 2 2 0 Septum formation initiator APG6_N PF17675.1 EMD67538.1 - 0.75 10.3 6.7 0.15 12.6 3.0 1.6 2 0 0 2 2 2 0 Apg6 coiled-coil region Rab_bind PF16704.5 EMD67538.1 - 9.9 6.3 8.2 4.4 7.4 3.6 2.5 2 0 0 2 2 2 0 Rab binding domain Adap_comp_sub PF00928.21 EMD67539.1 - 8.2e-86 287.6 0.0 1e-85 287.3 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 EMD67539.1 - 1.5e-05 24.9 0.2 2.8e-05 24.1 0.2 1.4 1 0 0 1 1 1 1 Clathrin adaptor complex small chain muHD PF10291.9 EMD67539.1 - 0.0069 15.9 0.2 0.011 15.2 0.2 1.4 1 0 0 1 1 1 1 Muniscin C-terminal mu homology domain RIBIOP_C PF04950.12 EMD67539.1 - 0.072 12.5 0.0 0.12 11.8 0.0 1.3 1 0 0 1 1 1 0 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal IGPD PF00475.18 EMD67541.1 - 4e-59 199.1 0.4 6e-59 198.5 0.4 1.3 1 0 0 1 1 1 1 Imidazoleglycerol-phosphate dehydratase RNA_pol_L_2 PF13656.6 EMD67542.1 - 3.1e-33 113.4 0.0 4e-33 113.0 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 EMD67542.1 - 2e-14 52.7 0.0 2.9e-14 52.2 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Complex1_LYR_2 PF13233.6 EMD67543.1 - 1.2e-06 29.2 1.8 2.3e-06 28.2 1.8 1.5 1 1 0 1 1 1 1 Complex1_LYR-like Complex1_LYR PF05347.15 EMD67543.1 - 0.00022 21.2 0.3 0.00043 20.3 0.3 1.6 1 0 0 1 1 1 1 Complex 1 protein (LYR family) G10 PF01125.17 EMD67544.1 - 4.1e-66 221.3 6.3 4.5e-66 221.1 6.3 1.0 1 0 0 1 1 1 1 G10 protein DUF1257 PF06868.11 EMD67544.1 - 0.063 13.5 0.2 0.092 13.0 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1257) DUF4448 PF14610.6 EMD67545.1 - 0.05 13.4 0.0 0.069 12.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) Oxidored_q2 PF00420.24 EMD67545.1 - 0.13 11.9 0.0 0.2 11.3 0.0 1.2 1 0 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L ArgJ PF01960.18 EMD67546.1 - 2.5e-149 497.1 2.1 2.9e-149 496.9 2.1 1.0 1 0 0 1 1 1 1 ArgJ family WD40 PF00400.32 EMD67547.1 - 4.7e-28 96.9 0.4 6.8e-10 39.4 0.0 3.7 3 0 0 3 3 3 3 WD domain, G-beta repeat Helo_like_N PF17111.5 EMD67547.1 - 2.8e-09 36.7 0.5 2.8e-09 36.7 0.5 1.7 2 0 0 2 2 2 1 Fungal N-terminal domain of STAND proteins AAA_16 PF13191.6 EMD67547.1 - 7e-09 36.3 11.2 4.4e-08 33.7 0.2 4.2 3 1 0 3 3 3 1 AAA ATPase domain NACHT PF05729.12 EMD67547.1 - 1.1e-08 35.2 0.0 3.4e-08 33.6 0.0 1.9 1 0 0 1 1 1 1 NACHT domain ANAPC4_WD40 PF12894.7 EMD67547.1 - 1.4e-08 34.9 0.0 0.0055 17.0 0.0 2.8 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EMD67547.1 - 2.6e-05 23.3 0.1 0.21 10.5 0.0 2.4 1 1 1 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 EMD67547.1 - 0.0026 17.7 0.1 5.6 7.0 0.0 3.2 3 0 0 3 3 3 1 WD40-like Beta Propeller Repeat Nup160 PF11715.8 EMD67547.1 - 0.0033 16.1 0.1 1.1 7.9 0.0 2.3 1 1 1 2 2 2 2 Nucleoporin Nup120/160 AAA PF00004.29 EMD67547.1 - 0.0045 17.4 0.0 0.013 15.9 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) NB-ARC PF00931.22 EMD67547.1 - 0.0068 15.6 0.0 0.019 14.1 0.0 1.7 1 0 0 1 1 1 1 NB-ARC domain DUF1513 PF07433.11 EMD67547.1 - 0.0069 15.5 0.1 1.4 8.0 0.0 2.3 1 1 1 2 2 2 2 Protein of unknown function (DUF1513) KAP_NTPase PF07693.14 EMD67547.1 - 0.0078 15.5 0.2 0.022 14.0 0.0 1.8 2 0 0 2 2 2 1 KAP family P-loop domain Gmad1 PF10647.9 EMD67547.1 - 0.01 15.6 0.1 0.23 11.2 0.1 2.2 1 1 1 2 2 2 0 Lipoprotein LpqB beta-propeller domain HIP1_clath_bdg PF16515.5 EMD67547.1 - 0.028 15.0 1.4 0.071 13.7 1.4 1.7 1 0 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 APS_kinase PF01583.20 EMD67547.1 - 0.052 13.4 0.1 0.11 12.4 0.1 1.5 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_30 PF13604.6 EMD67547.1 - 0.058 13.1 0.1 0.14 11.8 0.1 1.6 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EMD67547.1 - 0.06 13.9 0.0 0.28 11.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 EMD67547.1 - 0.08 13.2 0.3 0.47 10.7 0.0 2.6 2 1 0 2 2 2 0 AAA domain Tachylectin PF14517.6 EMD67547.1 - 0.086 12.4 0.0 0.9 9.0 0.0 1.9 1 1 0 1 1 1 0 Tachylectin PhoH PF02562.16 EMD67547.1 - 0.12 11.8 0.0 4.5 6.7 0.0 2.4 2 0 0 2 2 2 0 PhoH-like protein Forkhead PF00250.18 EMD67548.1 - 5.9e-34 116.2 0.5 1.1e-33 115.3 0.5 1.4 1 0 0 1 1 1 1 Forkhead domain DEAD PF00270.29 EMD67549.1 - 7.4e-38 130.1 0.0 1.2e-37 129.4 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EMD67549.1 - 1.1e-22 80.4 0.0 5.3e-21 75.0 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EMD67549.1 - 3.2e-05 24.0 0.0 5.3e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EMD67549.1 - 0.0058 15.9 0.0 0.009 15.2 0.0 1.2 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase PHF12_MRG_bd PF16737.5 EMD67549.1 - 0.02 14.6 0.1 0.82 9.4 0.0 2.6 2 0 0 2 2 2 0 PHD finger protein 12 MRG binding domain Pkinase PF00069.25 EMD67553.1 - 3.7e-08 33.1 0.0 6.6e-08 32.2 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain TPMT PF05724.11 EMD67554.1 - 1.8e-29 103.0 0.0 2.7e-29 102.4 0.0 1.2 1 0 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) Methyltransf_31 PF13847.6 EMD67554.1 - 4.1e-08 33.1 0.0 6.1e-08 32.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMD67554.1 - 2.2e-07 31.4 0.0 3.7e-07 30.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMD67554.1 - 1.1e-06 29.2 0.0 2e-06 28.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EMD67554.1 - 4.6e-06 26.6 0.0 7e-06 26.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMD67554.1 - 5.4e-06 27.1 0.0 9.2e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain N2227 PF07942.12 EMD67554.1 - 0.045 12.9 0.0 0.07 12.3 0.0 1.2 1 0 0 1 1 1 0 N2227-like protein ORC2 PF04084.14 EMD67555.1 - 3.7e-117 391.0 0.0 4.5e-117 390.7 0.0 1.1 1 0 0 1 1 1 1 Origin recognition complex subunit 2 ATG101 PF07855.12 EMD67556.1 - 1.9e-53 180.6 0.5 2.2e-53 180.4 0.5 1.0 1 0 0 1 1 1 1 Autophagy-related protein 101 Mo-co_dimer PF03404.16 EMD67556.1 - 0.076 13.0 0.0 0.11 12.6 0.0 1.4 1 0 0 1 1 1 0 Mo-co oxidoreductase dimerisation domain CobD_Cbib PF03186.13 EMD67556.1 - 0.11 11.7 0.0 0.14 11.3 0.0 1.2 1 0 0 1 1 1 0 CobD/Cbib protein MUG113 PF13455.6 EMD67557.1 - 4.3e-24 85.0 0.0 1.1e-23 83.7 0.0 1.7 2 0 0 2 2 2 1 Meiotically up-regulated gene 113 T5orf172 PF10544.9 EMD67557.1 - 2.8e-23 82.4 0.9 1.4e-22 80.2 0.9 2.2 1 1 0 1 1 1 1 T5orf172 domain ATP-grasp_2 PF08442.10 EMD67557.1 - 0.15 11.6 0.4 0.25 10.9 0.4 1.2 1 0 0 1 1 1 0 ATP-grasp domain Ndc1_Nup PF09531.10 EMD67557.1 - 6.4 5.3 5.5 9.1 4.8 5.5 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Cu_amine_oxid PF01179.20 EMD67558.1 - 1.2e-162 541.5 0.2 1.8e-162 541.0 0.2 1.2 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN3 PF02728.16 EMD67558.1 - 0.0015 18.9 0.0 0.0034 17.7 0.0 1.5 1 0 0 1 1 1 1 Copper amine oxidase, N3 domain Cu_amine_oxidN2 PF02727.16 EMD67558.1 - 0.0054 16.9 0.1 0.011 16.0 0.1 1.6 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain Methyltransf_8 PF05148.15 EMD67558.1 - 0.013 15.3 0.1 4.9 6.9 0.0 2.2 2 0 0 2 2 2 0 Hypothetical methyltransferase Nup88 PF10168.9 EMD67559.1 - 0.048 11.5 2.9 0.069 11.0 2.9 1.1 1 0 0 1 1 1 0 Nuclear pore component AAA_13 PF13166.6 EMD67559.1 - 0.058 12.0 4.2 0.088 11.4 4.2 1.2 1 0 0 1 1 1 0 AAA domain Golgin_A5 PF09787.9 EMD67559.1 - 0.35 10.3 9.1 0.7 9.3 9.1 1.4 1 0 0 1 1 1 0 Golgin subfamily A member 5 T3SSipB PF16535.5 EMD67559.1 - 4.1 7.9 9.6 2.8 8.4 7.0 2.0 2 0 0 2 2 2 0 Type III cell invasion protein SipB Methyltransf_31 PF13847.6 EMD67561.1 - 1.7e-23 83.1 0.0 2.9e-23 82.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMD67561.1 - 1.2e-17 64.3 0.0 2.6e-17 63.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EMD67561.1 - 1.3e-17 63.9 0.0 2.4e-17 63.1 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 EMD67561.1 - 6.1e-15 55.8 0.0 1.2e-14 54.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMD67561.1 - 5.9e-14 52.5 0.0 1.3e-13 51.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain GFA PF04828.14 EMD67561.1 - 3.1e-13 49.9 0.6 8e-13 48.6 0.6 1.8 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme Methyltransf_23 PF13489.6 EMD67561.1 - 7.1e-12 45.5 0.0 1.2e-11 44.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 EMD67561.1 - 2.5e-08 33.9 0.0 4.4e-08 33.1 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.14 EMD67561.1 - 1.2e-05 24.9 0.0 2.5e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain FtsJ PF01728.19 EMD67561.1 - 0.00014 22.1 0.0 0.00037 20.7 0.0 1.7 1 1 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_32 PF13679.6 EMD67561.1 - 0.00017 21.6 0.0 0.00031 20.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_24 PF13578.6 EMD67561.1 - 0.0083 17.1 0.1 0.032 15.3 0.0 2.0 3 0 0 3 3 2 1 Methyltransferase domain CMAS PF02353.20 EMD67561.1 - 0.012 14.9 0.0 0.021 14.1 0.0 1.4 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase GCD14 PF08704.10 EMD67561.1 - 0.012 15.3 0.0 0.056 13.1 0.0 2.0 2 0 0 2 2 2 0 tRNA methyltransferase complex GCD14 subunit PrmA PF06325.13 EMD67561.1 - 0.027 13.9 0.0 0.048 13.0 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_9 PF08003.11 EMD67561.1 - 0.03 13.2 0.0 0.046 12.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) DUF4132 PF13569.6 EMD67561.1 - 0.044 13.6 0.1 0.08 12.7 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4132) RrnaAD PF00398.20 EMD67561.1 - 0.064 12.3 0.0 0.11 11.6 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Methyltr_RsmB-F PF01189.17 EMD67561.1 - 0.072 12.7 0.0 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 16S rRNA methyltransferase RsmB/F DOT1 PF08123.13 EMD67561.1 - 0.096 12.2 0.0 0.21 11.1 0.0 1.5 1 0 0 1 1 1 0 Histone methylation protein DOT1 Rpr2 PF04032.16 EMD67561.1 - 0.18 12.1 0.6 0.42 10.9 0.0 1.8 1 1 1 2 2 2 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain DUF463 PF04317.12 EMD67563.1 - 0.05 12.5 0.0 0.064 12.2 0.0 1.2 1 0 0 1 1 1 0 YcjX-like family, DUF463 PGDYG PF14083.6 EMD67563.1 - 0.07 13.4 0.0 0.16 12.2 0.0 1.5 1 0 0 1 1 1 0 PGDYG protein AXE1 PF05448.12 EMD67563.1 - 0.12 11.0 0.1 0.2 10.3 0.1 1.2 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) SNF2_N PF00176.23 EMD67564.1 - 4.4e-73 246.0 1.0 4.4e-73 246.0 1.0 2.6 2 0 0 2 2 2 1 SNF2 family N-terminal domain Bromodomain PF00439.25 EMD67564.1 - 1.3e-21 76.5 0.4 1.3e-21 76.5 0.4 2.7 4 0 0 4 4 4 1 Bromodomain Helicase_C PF00271.31 EMD67564.1 - 1e-19 70.9 1.3 1.1e-17 64.4 0.0 3.8 3 1 1 4 4 4 1 Helicase conserved C-terminal domain HSA PF07529.13 EMD67564.1 - 4.9e-17 62.0 14.5 4.9e-17 62.0 14.5 4.1 2 1 1 3 3 3 1 HSA QLQ PF08880.11 EMD67564.1 - 1.3e-12 47.2 0.8 1.3e-12 47.2 0.8 2.4 2 0 0 2 2 2 1 QLQ SnAC PF14619.6 EMD67564.1 - 2.1e-12 47.5 0.1 2.1e-12 47.5 0.1 3.8 5 1 0 5 5 5 1 Snf2-ATP coupling, chromatin remodelling complex ResIII PF04851.15 EMD67564.1 - 4.2e-10 39.9 0.0 4.2e-10 39.9 0.0 3.5 4 0 0 4 4 4 1 Type III restriction enzyme, res subunit Chalcone_2 PF16035.5 EMD67564.1 - 2.4 7.9 11.7 8.8 6.0 11.7 2.1 1 0 0 1 1 1 0 Chalcone isomerase like His_biosynth PF00977.21 EMD67565.1 - 2e-33 115.8 0.0 2.5e-33 115.5 0.0 1.1 1 0 0 1 1 1 1 Histidine biosynthesis protein TMP-TENI PF02581.17 EMD67565.1 - 0.081 12.3 0.1 0.46 9.8 0.1 2.0 2 0 0 2 2 2 0 Thiamine monophosphate synthase DUF4602 PF15375.6 EMD67566.1 - 1.9e-10 41.2 23.7 7.3e-10 39.3 23.7 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF4602) EMC3_TMCO1 PF01956.16 EMD67566.1 - 2.2 8.0 3.3 1.3 8.8 0.8 1.7 2 0 0 2 2 2 0 Integral membrane protein EMC3/TMCO1-like zf-C2H2 PF00096.26 EMD67570.1 - 4.9e-22 77.1 18.4 4.1e-05 23.8 0.9 4.5 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMD67570.1 - 4.9e-16 58.3 21.9 7.1e-08 32.5 0.4 4.8 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMD67570.1 - 1.3e-10 41.2 16.9 0.029 15.2 0.1 4.5 4 0 0 4 4 4 4 C2H2-type zinc finger zf-met PF12874.7 EMD67570.1 - 0.00014 22.1 7.8 0.27 11.7 0.0 4.0 4 0 0 4 4 4 2 Zinc-finger of C2H2 type zf-C2H2_aberr PF17017.5 EMD67570.1 - 0.00027 21.1 6.3 0.21 11.7 0.3 3.3 2 1 1 3 3 3 2 Aberrant zinc-finger zf-C2H2_8 PF15909.5 EMD67570.1 - 0.0005 20.3 8.9 0.016 15.5 2.0 3.7 2 1 2 4 4 4 1 C2H2-type zinc ribbon FOXP-CC PF16159.5 EMD67570.1 - 0.0051 17.4 3.5 21 5.9 0.1 3.5 2 1 1 3 3 3 0 FOXP coiled-coil domain zf-LYAR PF08790.11 EMD67570.1 - 0.017 15.0 7.2 7.1 6.6 0.5 4.2 4 0 0 4 4 4 0 LYAR-type C2HC zinc finger C1_4 PF07975.12 EMD67570.1 - 0.1 12.9 1.5 0.78 10.0 0.2 2.6 2 0 0 2 2 2 0 TFIIH C1-like domain zf-DNA_Pol PF08996.10 EMD67570.1 - 2.5 7.8 6.9 6 6.6 0.6 2.4 1 1 2 3 3 3 0 DNA Polymerase alpha zinc finger zf-C2HC_2 PF13913.6 EMD67570.1 - 2.9 7.9 5.1 5.4 7.0 0.2 3.3 3 0 0 3 3 3 0 zinc-finger of a C2HC-type zf-C2H2_6 PF13912.6 EMD67570.1 - 7.2 6.7 16.6 0.63 10.1 0.1 4.3 4 0 0 4 4 4 0 C2H2-type zinc finger Pro_racemase PF05544.11 EMD67575.1 - 2.4e-120 401.5 0.4 2.7e-120 401.3 0.4 1.0 1 0 0 1 1 1 1 Proline racemase FA_hydroxylase PF04116.13 EMD67576.1 - 2e-22 80.0 20.5 2e-22 80.0 20.5 2.1 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily MMR_HSR1_Xtn PF16897.5 EMD67577.1 - 6.6e-35 119.3 1.2 1.4e-34 118.3 0.5 1.8 2 0 0 2 2 2 1 C-terminal region of MMR_HSR1 domain MMR_HSR1 PF01926.23 EMD67577.1 - 1.5e-20 73.4 0.0 4.1e-20 72.0 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase TGS PF02824.21 EMD67577.1 - 1.4e-19 69.9 0.7 2.2e-19 69.2 0.2 1.6 2 0 0 2 2 2 1 TGS domain FeoB_N PF02421.18 EMD67577.1 - 5.1e-11 42.3 0.0 8.3e-11 41.7 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EMD67577.1 - 0.00072 19.7 0.1 0.76 9.8 0.0 2.5 1 1 1 2 2 2 2 Dynamin family Roc PF08477.13 EMD67577.1 - 0.047 13.9 0.1 0.64 10.3 0.0 2.3 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase MCM PF00493.23 EMD67577.1 - 0.049 12.7 0.0 0.23 10.6 0.0 1.9 2 0 0 2 2 2 0 MCM P-loop domain MeaB PF03308.16 EMD67577.1 - 0.066 12.2 0.1 0.15 11.0 0.1 1.6 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB DUF4387 PF14330.6 EMD67577.1 - 0.13 13.0 0.1 0.26 12.0 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4387) MBOAT_2 PF13813.6 EMD67578.1 - 2.4e-20 72.6 2.2 7.2e-20 71.1 1.7 2.1 2 0 0 2 2 2 1 Membrane bound O-acyl transferase family Erf4 PF10256.9 EMD67580.1 - 1.3e-38 131.7 0.0 1.8e-38 131.2 0.0 1.2 1 0 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family GATA-N PF05349.12 EMD67581.1 - 0.15 12.4 2.4 8.1 6.7 0.3 2.1 2 0 0 2 2 2 0 GATA-type transcription activator, N-terminal DUF4131 PF13567.6 EMD67581.1 - 0.79 9.4 5.8 0.71 9.5 1.9 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) DUF4203 PF13886.6 EMD67582.1 - 1.4e-48 165.3 26.4 1.8e-48 164.9 26.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4203) DUF2500 PF10694.9 EMD67582.1 - 0.081 13.4 1.4 12 6.5 0.1 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2500) GSH_synth_ATP PF03917.17 EMD67583.1 - 1.1e-143 478.6 0.0 1.2e-143 478.4 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic glutathione synthase, ATP binding domain GSH_synthase PF03199.15 EMD67583.1 - 2.2e-34 118.0 0.0 4e-34 117.1 0.0 1.5 1 0 0 1 1 1 1 Eukaryotic glutathione synthase Aminotran_1_2 PF00155.21 EMD67585.1 - 5.6e-83 279.1 0.0 7.3e-83 278.7 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EMD67585.1 - 1.7e-06 26.9 0.0 2.6e-06 26.2 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 EMD67585.1 - 0.0001 21.4 0.0 0.00019 20.5 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 EMD67585.1 - 0.0037 16.6 0.2 0.0062 15.9 0.2 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.21 EMD67585.1 - 0.014 14.7 1.7 0.026 13.8 0.4 1.9 2 1 0 2 2 2 0 Beta-eliminating lyase DuffyBP_N PF12377.8 EMD67585.1 - 0.054 13.9 0.0 0.17 12.3 0.0 1.8 1 0 0 1 1 1 0 Duffy binding protein N terminal THOC2_N PF16134.5 EMD67586.1 - 8.4e-219 728.3 0.0 1.2e-218 727.8 0.0 1.3 1 0 0 1 1 1 1 THO complex subunit 2 N-terminus Tho2 PF11262.8 EMD67586.1 - 3.4e-77 259.6 0.0 6.4e-77 258.7 0.0 1.4 1 0 0 1 1 1 1 Transcription factor/nuclear export subunit protein 2 Thoc2 PF11732.8 EMD67586.1 - 1.1e-23 83.1 0.1 2.3e-23 82.0 0.1 1.6 1 0 0 1 1 1 1 Transcription- and export-related complex subunit MFS_1 PF07690.16 EMD67587.1 - 1e-31 110.2 37.0 1e-31 110.2 37.0 1.6 1 1 1 2 2 2 1 Major Facilitator Superfamily DUF3040 PF11239.8 EMD67587.1 - 0.072 13.4 0.2 0.42 10.9 0.2 2.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) DUF3119 PF11317.8 EMD67587.1 - 0.4 11.0 2.8 2 8.7 0.5 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3119) Myb_DNA-bind_7 PF15963.5 EMD67588.1 - 1.8e-22 79.0 0.5 4.8e-22 77.6 0.2 1.9 1 1 0 1 1 1 1 Myb DNA-binding like Myb_DNA-binding PF00249.31 EMD67588.1 - 0.0029 17.7 0.0 0.0092 16.2 0.0 1.9 1 0 0 1 1 1 1 Myb-like DNA-binding domain BRE1 PF08647.11 EMD67589.1 - 2e-23 82.2 9.8 2e-23 82.2 9.8 7.4 4 2 2 6 6 4 1 BRE1 E3 ubiquitin ligase zf-C3HC4_3 PF13920.6 EMD67589.1 - 5.9e-09 35.6 8.5 1.2e-08 34.7 8.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EMD67589.1 - 6.7e-09 35.5 10.9 1.2e-08 34.6 10.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EMD67589.1 - 2.8e-07 30.3 6.8 5e-07 29.5 6.8 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 EMD67589.1 - 4.6e-07 29.6 11.6 8.9e-07 28.7 11.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EMD67589.1 - 5.9e-07 29.4 6.2 1.2e-06 28.5 6.2 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 EMD67589.1 - 1.6e-06 28.4 8.6 3.2e-06 27.4 8.6 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 EMD67589.1 - 8.7e-06 25.6 11.3 1.6e-05 24.7 11.3 1.5 1 0 0 1 1 1 1 zinc-RING finger domain DUF1272 PF06906.11 EMD67589.1 - 0.001 19.1 5.4 0.0025 17.9 5.4 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1272) zf-C3HC4_4 PF15227.6 EMD67589.1 - 0.004 17.3 7.1 0.008 16.3 7.1 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING ATG16 PF08614.11 EMD67589.1 - 0.0062 16.8 22.0 0.0062 16.8 22.0 5.9 1 1 3 5 5 5 1 Autophagy protein 16 (ATG16) zf-rbx1 PF12678.7 EMD67589.1 - 0.0084 16.4 5.5 0.0084 16.4 5.5 2.3 2 0 0 2 2 2 1 RING-H2 zinc finger domain DZR PF12773.7 EMD67589.1 - 0.014 15.4 7.3 0.033 14.2 7.3 1.6 1 0 0 1 1 1 0 Double zinc ribbon zf-RING_6 PF14835.6 EMD67589.1 - 0.015 15.1 3.2 0.03 14.2 3.2 1.4 1 0 0 1 1 1 0 zf-RING of BARD1-type protein JIP_LZII PF16471.5 EMD67589.1 - 0.03 14.5 1.9 0.03 14.5 1.9 8.2 7 1 1 9 9 9 0 JNK-interacting protein leucine zipper II zf-RING_4 PF14570.6 EMD67589.1 - 0.049 13.4 7.3 0.11 12.3 7.3 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain DUF4763 PF15960.5 EMD67589.1 - 0.071 12.4 0.0 0.071 12.4 0.0 5.6 3 2 2 5 5 5 0 Domain of unknown function (DUF4763) zf-C2H2 PF00096.26 EMD67589.1 - 0.11 13.0 0.1 0.11 13.0 0.1 2.7 3 0 0 3 3 1 0 Zinc finger, C2H2 type DUF1192 PF06698.11 EMD67589.1 - 0.17 12.0 0.2 0.17 12.0 0.2 5.7 6 0 0 6 6 5 0 Protein of unknown function (DUF1192) APG6_N PF17675.1 EMD67589.1 - 0.19 12.2 92.8 2.7 8.5 7.7 7.3 2 1 4 7 7 7 0 Apg6 coiled-coil region zinc-ribbons_6 PF07191.12 EMD67589.1 - 0.2 11.6 6.8 0.67 10.0 6.8 1.9 1 0 0 1 1 1 0 zinc-ribbons zf-ribbon_3 PF13248.6 EMD67589.1 - 0.29 10.6 4.1 0.15 11.5 1.3 2.1 2 0 0 2 2 2 0 zinc-ribbon domain zf-C2H2_4 PF13894.6 EMD67589.1 - 0.32 11.9 0.1 0.32 11.9 0.1 2.9 3 0 0 3 3 2 0 C2H2-type zinc finger FYVE PF01363.21 EMD67589.1 - 1.6 8.9 10.4 5.3 7.3 5.5 2.7 1 1 1 2 2 2 0 FYVE zinc finger zf-RING_10 PF16685.5 EMD67589.1 - 1.7 8.8 9.6 0.97 9.6 6.1 2.3 2 0 0 2 2 2 0 zinc RING finger of MSL2 EzrA PF06160.12 EMD67589.1 - 2.8 6.0 61.3 0.46 8.6 2.2 5.0 3 1 2 5 5 5 0 Septation ring formation regulator, EzrA Spo12 PF05032.12 EMD67590.1 - 2.4e-15 56.1 4.7 5.2e-15 55.1 4.7 1.6 1 0 0 1 1 1 1 Spo12 family UreF PF01730.16 EMD67591.1 - 1.1e-23 84.3 2.1 1.7e-23 83.7 2.1 1.2 1 0 0 1 1 1 1 UreF Sugarporin_N PF11471.8 EMD67591.1 - 0.048 13.6 0.1 0.17 11.8 0.1 1.9 1 0 0 1 1 1 0 Maltoporin periplasmic N-terminal extension Lipase_GDSL_2 PF13472.6 EMD67592.1 - 1.2e-12 48.6 0.0 2.9e-12 47.3 0.0 1.7 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EMD67592.1 - 2.1e-05 24.6 0.0 3.1e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase PglD_N PF17836.1 EMD67592.1 - 0.022 15.4 0.3 0.066 13.9 0.1 1.9 2 0 0 2 2 2 0 PglD N-terminal domain DUF2423 PF10338.9 EMD67593.1 - 3.4e-20 72.0 1.3 3.4e-20 72.0 1.3 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF2423) PINIT PF14324.6 EMD67594.1 - 4e-35 121.3 0.1 8.4e-35 120.3 0.1 1.6 1 0 0 1 1 1 1 PINIT domain zf-MIZ PF02891.20 EMD67594.1 - 6.4e-20 70.7 3.8 1e-19 70.0 3.8 1.3 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-Nse PF11789.8 EMD67594.1 - 1.6e-07 31.0 1.5 3.2e-07 30.1 1.5 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit SAP PF02037.27 EMD67594.1 - 1.8e-06 27.5 0.4 3.5e-06 26.6 0.4 1.5 1 0 0 1 1 1 1 SAP domain Prok-RING_4 PF14447.6 EMD67594.1 - 0.005 16.7 1.6 0.0096 15.8 1.6 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-Sec23_Sec24 PF04810.15 EMD67594.1 - 0.18 11.9 2.5 0.35 10.9 2.5 1.5 1 0 0 1 1 1 0 Sec23/Sec24 zinc finger Peptidase_M24 PF00557.24 EMD67595.1 - 2.7e-49 167.7 0.0 7e-49 166.3 0.0 1.7 2 0 0 2 2 2 1 Metallopeptidase family M24 Creatinase_N PF01321.18 EMD67595.1 - 0.00031 21.4 0.0 0.00051 20.7 0.0 1.4 1 0 0 1 1 1 1 Creatinase/Prolidase N-terminal domain Pro_isomerase PF00160.21 EMD67597.1 - 8.1e-42 143.2 0.0 1.5e-41 142.3 0.0 1.5 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD PHD_3 PF13922.6 EMD67597.1 - 0.024 15.0 0.2 0.069 13.5 0.2 1.7 1 0 0 1 1 1 0 PHD domain of transcriptional enhancer, Asx MBOAT PF03062.19 EMD67598.1 - 2.3e-54 185.1 7.4 4.6e-54 184.1 7.4 1.4 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family Pollen_allerg_2 PF01620.16 EMD67598.1 - 0.049 13.8 0.1 0.12 12.6 0.1 1.6 1 0 0 1 1 1 0 Ribonuclease (pollen allergen) TipE PF16972.5 EMD67599.1 - 0.93 8.6 3.0 0.29 10.3 0.3 1.4 2 0 0 2 2 2 0 Na+ channel auxiliary subunit TipE SAYSvFN PF10260.9 EMD67599.1 - 2.3 8.2 0.0 2.3 8.2 0.0 3.3 4 0 0 4 4 4 0 Uncharacterized conserved domain (SAYSvFN) Amidase PF01425.21 EMD67600.1 - 2.6e-86 290.4 0.0 3.7e-86 289.9 0.0 1.2 1 0 0 1 1 1 1 Amidase MFS_1 PF07690.16 EMD67601.1 - 1.8e-30 106.1 28.1 1.8e-30 106.1 28.1 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily BT1 PF03092.16 EMD67601.1 - 0.00038 18.8 0.3 0.00038 18.8 0.3 1.8 2 0 0 2 2 2 1 BT1 family DUF4956 PF16316.5 EMD67601.1 - 3.6 7.2 0.0 3.6 7.2 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4956) DER1 PF04511.15 EMD67602.1 - 9.4e-48 162.7 7.7 1.1e-47 162.4 7.7 1.0 1 0 0 1 1 1 1 Der1-like family Histone PF00125.24 EMD67603.1 - 1.3e-41 142.0 0.3 1.6e-41 141.8 0.3 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 EMD67603.1 - 3.1e-06 27.3 0.1 4.6e-06 26.7 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 EMD67603.1 - 5.5e-06 26.7 0.1 8.2e-06 26.1 0.1 1.2 1 0 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 EMD67603.1 - 0.013 15.7 0.4 0.024 14.9 0.4 1.4 1 1 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 EMD67603.1 - 0.014 15.5 0.0 0.019 15.0 0.0 1.2 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit Abhydrolase_6 PF12697.7 EMD67604.1 - 3.3e-09 37.7 1.9 4.7e-09 37.2 1.9 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EMD67604.1 - 2.1e-07 30.5 0.0 0.00024 20.5 0.1 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EMD67604.1 - 7.1e-07 29.1 0.1 0.00051 19.8 0.1 2.3 2 0 0 2 2 2 2 alpha/beta hydrolase fold LIP PF03583.14 EMD67604.1 - 2.2e-05 24.0 0.3 0.11 11.8 0.2 2.1 2 0 0 2 2 2 2 Secretory lipase Peptidase_S9 PF00326.21 EMD67604.1 - 0.013 15.0 0.8 1.6 8.2 0.5 2.3 2 0 0 2 2 2 0 Prolyl oligopeptidase family DDE_1 PF03184.19 EMD67605.1 - 4e-11 42.9 0.1 1.7e-09 37.6 0.0 2.3 1 1 1 2 2 2 2 DDE superfamily endonuclease zf-C2H2_10 PF16588.5 EMD67605.1 - 0.68 9.7 10.4 0.26 11.0 7.5 1.8 2 0 0 2 2 2 0 C2H2 zinc-finger zf-CCHC_6 PF15288.6 EMD67605.1 - 4.7 7.1 6.4 11 5.9 4.0 2.3 2 0 0 2 2 2 0 Zinc knuckle Cyt-b5 PF00173.28 EMD67609.1 - 1.9e-14 53.6 0.0 1.1e-13 51.1 0.0 2.3 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain FAD_binding_1 PF00667.20 EMD67609.1 - 8.2e-13 48.4 0.0 1.8e-12 47.3 0.0 1.6 1 0 0 1 1 1 1 FAD binding domain IDO PF01231.18 EMD67609.1 - 2e-09 36.8 0.0 2.4e-08 33.2 0.0 2.1 1 1 0 2 2 2 1 Indoleamine 2,3-dioxygenase NAD_binding_1 PF00175.21 EMD67609.1 - 3.9e-08 33.9 0.0 8.6e-08 32.8 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Peptidase_S10 PF00450.22 EMD67611.1 - 1e-85 288.7 2.1 1.6e-85 288.0 2.1 1.3 1 1 0 1 1 1 1 Serine carboxypeptidase Laminin_I PF06008.14 EMD67612.1 - 0.002 17.9 1.4 0.0023 17.7 1.4 1.1 1 0 0 1 1 1 1 Laminin Domain I NucS PF01939.16 EMD67612.1 - 0.008 15.5 0.5 0.0085 15.5 0.5 1.1 1 0 0 1 1 1 1 Endonuclease NucS Tautomerase_2 PF14552.6 EMD67612.1 - 0.058 13.5 0.9 0.11 12.6 0.3 1.7 2 0 0 2 2 2 0 Tautomerase enzyme Histone_HNS PF00816.21 EMD67612.1 - 0.29 12.0 4.0 12 6.7 4.4 2.0 1 1 1 2 2 2 0 H-NS histone family VPS11_C PF12451.8 EMD67612.1 - 0.36 11.1 2.6 20 5.5 0.0 2.2 2 0 0 2 2 2 0 Vacuolar protein sorting protein 11 C terminal MFS_1 PF07690.16 EMD67613.1 - 5.1e-22 78.3 44.1 7.6e-22 77.7 44.1 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_2 PF13347.6 EMD67613.1 - 5.6e-05 21.9 27.0 0.0014 17.2 10.0 2.8 1 1 1 2 2 2 2 MFS/sugar transport protein PetN PF03742.14 EMD67613.1 - 0.2 11.6 6.8 7.8 6.5 0.2 4.1 3 0 0 3 3 3 0 PetN DUF89 PF01937.19 EMD67614.1 - 8.7e-137 455.8 0.1 1e-136 455.6 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF89 MFS_1 PF07690.16 EMD67616.1 - 1.2e-33 116.6 26.9 1.2e-33 116.6 26.9 1.8 1 1 0 1 1 1 1 Major Facilitator Superfamily AMP-binding PF00501.28 EMD67617.1 - 1.9e-64 217.8 0.0 2.8e-64 217.3 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme MFS_1 PF07690.16 EMD67617.1 - 8.4e-39 133.5 16.7 8.4e-39 133.5 16.7 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EMD67617.1 - 2.3e-08 33.3 1.0 2.3e-08 33.3 1.0 2.0 2 0 0 2 2 2 1 Sugar (and other) transporter AMP-binding_C PF13193.6 EMD67617.1 - 6.7e-06 27.0 0.1 2.5e-05 25.1 0.0 2.1 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain MFS_1_like PF12832.7 EMD67617.1 - 0.36 9.6 5.6 5.8 5.7 5.6 2.7 1 1 0 1 1 1 0 MFS_1 like family 4HBT PF03061.22 EMD67618.1 - 4.3e-07 30.2 0.0 7.4e-07 29.4 0.0 1.4 1 0 0 1 1 1 1 Thioesterase superfamily Ribonuclease_3 PF00636.26 EMD67619.1 - 1.5e-13 51.3 0.3 5.5e-13 49.5 0.0 2.2 2 0 0 2 2 2 1 Ribonuclease III domain Ribonucleas_3_3 PF14622.6 EMD67619.1 - 2.2e-12 47.3 0.0 4.4e-12 46.3 0.0 1.6 1 0 0 1 1 1 1 Ribonuclease-III-like FDF PF09532.10 EMD67619.1 - 0.3 12.0 9.8 0.87 10.5 9.8 1.7 1 0 0 1 1 1 0 FDF domain UPF0239 PF06783.11 EMD67619.1 - 7.1 6.9 10.0 21 5.4 10.0 1.9 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0239) CCDC106 PF15794.5 EMD67619.1 - 9 5.9 13.0 18 5.0 13.0 1.5 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 Med19 PF10278.9 EMD67619.1 - 9.7 6.1 15.6 35 4.3 15.0 2.2 2 0 0 2 2 2 0 Mediator of RNA pol II transcription subunit 19 GARS_A PF01071.19 EMD67620.1 - 9.9e-85 283.2 0.0 1.8e-84 282.4 0.0 1.4 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain GARS_N PF02844.15 EMD67620.1 - 1.1e-33 115.9 0.0 2.7e-33 114.6 0.0 1.7 2 0 0 2 2 1 1 Phosphoribosylglycinamide synthetase, N domain GARS_C PF02843.16 EMD67620.1 - 2.2e-27 95.2 1.6 3.7e-27 94.4 0.5 2.1 2 0 0 2 2 2 1 Phosphoribosylglycinamide synthetase, C domain ATP-grasp_3 PF02655.14 EMD67620.1 - 2.3e-05 24.5 0.0 8.7e-05 22.6 0.0 1.9 1 1 0 1 1 1 1 ATP-grasp domain ATP-grasp PF02222.22 EMD67620.1 - 3.7e-05 23.4 0.0 6.7e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain CPSase_L_D2 PF02786.17 EMD67620.1 - 8.2e-05 22.2 0.1 0.00015 21.3 0.1 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATP-grasp_4 PF13535.6 EMD67620.1 - 0.0026 17.4 0.0 0.0053 16.4 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain RimK PF08443.11 EMD67620.1 - 0.013 15.1 0.0 0.026 14.1 0.0 1.4 1 0 0 1 1 1 0 RimK-like ATP-grasp domain ATP-grasp_2 PF08442.10 EMD67620.1 - 0.028 14.0 0.0 0.05 13.1 0.0 1.3 1 0 0 1 1 1 0 ATP-grasp domain ATPgrasp_Ter PF15632.6 EMD67620.1 - 0.044 13.5 0.0 19 5.0 0.0 2.9 3 0 0 3 3 3 0 ATP-grasp in the biosynthetic pathway with Ter operon Dala_Dala_lig_C PF07478.13 EMD67620.1 - 0.13 11.7 0.0 0.27 10.8 0.0 1.5 1 0 0 1 1 1 0 D-ala D-ala ligase C-terminus ATPgrasp_ST PF14397.6 EMD67620.1 - 0.14 11.4 0.0 0.3 10.3 0.0 1.5 2 0 0 2 2 2 0 Sugar-transfer associated ATP-grasp DCP1 PF06058.13 EMD67621.1 - 3.7e-31 107.5 0.0 5.7e-31 106.9 0.0 1.3 1 0 0 1 1 1 1 Dcp1-like decapping family Exo_endo_phos PF03372.23 EMD67622.1 - 2.1e-06 27.4 0.0 3.9e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family RhoGAP PF00620.27 EMD67622.1 - 4.2e-05 23.4 0.1 0.00012 21.9 0.1 1.8 1 1 0 1 1 1 1 RhoGAP domain LIDHydrolase PF10230.9 EMD67623.1 - 1.6e-75 254.1 0.0 1.9e-75 253.8 0.0 1.0 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Abhydrolase_6 PF12697.7 EMD67623.1 - 3.1e-05 24.7 0.1 4.5e-05 24.2 0.1 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.13 EMD67623.1 - 0.00065 19.6 0.0 0.0015 18.4 0.0 1.6 1 1 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EMD67623.1 - 0.003 16.9 0.0 0.0055 16.0 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 DUF900 PF05990.12 EMD67623.1 - 0.0051 16.4 0.0 0.0081 15.7 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF900) Thioesterase PF00975.20 EMD67623.1 - 0.017 15.3 0.0 0.028 14.5 0.0 1.3 1 0 0 1 1 1 0 Thioesterase domain Abhydrolase_2 PF02230.16 EMD67623.1 - 0.019 14.8 0.0 0.034 13.9 0.0 1.3 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase LCAT PF02450.15 EMD67623.1 - 0.021 14.0 0.0 0.044 13.0 0.0 1.3 1 1 0 1 1 1 0 Lecithin:cholesterol acyltransferase Lipase_3 PF01764.25 EMD67623.1 - 0.039 13.8 0.0 0.072 12.9 0.0 1.5 1 1 0 1 1 1 0 Lipase (class 3) YuiB PF14068.6 EMD67623.1 - 0.084 13.5 0.0 0.31 11.6 0.0 1.9 2 0 0 2 2 2 0 Putative membrane protein PGAP1 PF07819.13 EMD67623.1 - 0.14 11.8 0.0 0.23 11.2 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein Pep3_Vps18 PF05131.14 EMD67624.1 - 3.3e-48 163.3 0.0 1.3e-47 161.3 0.0 2.1 2 0 0 2 2 2 1 Pep3/Vps18/deep orange family Clathrin PF00637.20 EMD67624.1 - 9.6e-11 41.7 8.9 4.6e-09 36.3 1.1 3.1 3 1 0 3 3 3 2 Region in Clathrin and VPS Zn_ribbon_17 PF17120.5 EMD67624.1 - 0.0012 18.5 0.4 0.0023 17.5 0.4 1.5 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type Vps39_2 PF10367.9 EMD67624.1 - 0.0013 19.2 0.0 0.0031 18.0 0.0 1.6 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 zf-C3HC4_2 PF13923.6 EMD67624.1 - 0.0023 17.7 0.9 0.0056 16.5 0.9 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EMD67624.1 - 0.0035 17.3 0.2 0.0072 16.3 0.2 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 EMD67624.1 - 0.013 15.9 0.8 0.028 14.8 0.8 1.6 1 0 0 1 1 1 0 Ring finger domain DUF2175 PF09943.9 EMD67624.1 - 0.031 14.6 4.0 0.057 13.7 0.1 3.0 3 0 0 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2175) zf-RING_UBOX PF13445.6 EMD67624.1 - 0.078 13.0 0.4 0.18 11.9 0.4 1.6 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4 PF00097.25 EMD67624.1 - 0.11 12.3 0.3 0.25 11.3 0.3 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF1664 PF07889.12 EMD67624.1 - 0.12 12.4 1.7 0.7 9.9 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) zf-rbx1 PF12678.7 EMD67624.1 - 0.13 12.6 0.4 0.32 11.3 0.4 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger domain DUF3943 PF13084.6 EMD67624.1 - 0.16 11.9 0.0 2.6 7.9 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3943) XhlA PF10779.9 EMD67624.1 - 0.22 11.8 1.1 1.2 9.3 0.6 2.3 2 0 0 2 2 2 0 Haemolysin XhlA zf-RING_11 PF17123.5 EMD67624.1 - 0.23 11.2 8.3 0.03 14.1 4.0 1.8 2 0 0 2 2 2 0 RING-like zinc finger zf-C3H2C3 PF17122.5 EMD67624.1 - 2.9 8.0 8.1 0.1 12.7 2.0 1.8 2 0 0 2 2 1 0 Zinc-finger TPR_2 PF07719.17 EMD67625.1 - 1.1e-29 100.1 28.5 0.0019 18.1 0.0 13.8 14 0 0 14 14 13 7 Tetratricopeptide repeat TPR_1 PF00515.28 EMD67625.1 - 9.7e-23 79.0 24.3 0.001 18.8 0.0 11.7 13 0 0 13 13 12 6 Tetratricopeptide repeat TPR_19 PF14559.6 EMD67625.1 - 2.3e-21 76.1 21.7 0.00062 20.2 0.2 10.3 9 3 1 11 11 10 5 Tetratricopeptide repeat TPR_14 PF13428.6 EMD67625.1 - 9.3e-18 63.4 24.3 3.1e-05 24.4 0.0 13.4 12 4 3 15 15 12 2 Tetratricopeptide repeat TPR_8 PF13181.6 EMD67625.1 - 8.5e-16 56.8 16.7 0.021 15.0 0.0 11.6 14 0 0 14 14 12 4 Tetratricopeptide repeat TPR_6 PF13174.6 EMD67625.1 - 3.4e-15 55.6 22.2 6.5e-05 23.3 0.0 12.5 14 0 0 14 14 12 2 Tetratricopeptide repeat TPR_7 PF13176.6 EMD67625.1 - 1e-14 53.3 11.3 0.00078 19.3 0.0 10.4 11 0 0 11 11 10 3 Tetratricopeptide repeat TPR_12 PF13424.6 EMD67625.1 - 4.4e-14 52.5 22.6 0.004 17.4 0.4 9.8 8 3 2 10 10 9 5 Tetratricopeptide repeat TPR_16 PF13432.6 EMD67625.1 - 5.7e-14 52.5 21.9 0.03 15.0 0.0 9.6 9 1 1 10 10 9 4 Tetratricopeptide repeat TPR_17 PF13431.6 EMD67625.1 - 1.5e-09 37.6 14.7 0.38 11.3 0.1 10.8 12 0 0 12 12 11 2 Tetratricopeptide repeat TPR_11 PF13414.6 EMD67625.1 - 2.1e-09 36.9 23.6 0.085 12.6 0.1 9.8 11 0 0 11 11 11 4 TPR repeat TPR_9 PF13371.6 EMD67625.1 - 0.00056 20.0 9.6 1.8 8.7 0.0 8.4 10 1 0 10 10 10 1 Tetratricopeptide repeat PknG_TPR PF16918.5 EMD67625.1 - 0.0088 14.8 4.8 0.74 8.5 0.0 4.0 5 0 0 5 5 5 1 Protein kinase G tetratricopeptide repeat ANAPC3 PF12895.7 EMD67625.1 - 0.055 13.7 20.4 0.1 12.8 0.3 6.9 8 1 1 9 9 8 0 Anaphase-promoting complex, cyclosome, subunit 3 PPR PF01535.20 EMD67625.1 - 0.06 13.6 0.0 24 5.4 0.0 4.2 4 0 0 4 4 3 0 PPR repeat Fis1_TPR_C PF14853.6 EMD67625.1 - 0.064 13.3 8.4 3.4 7.8 0.1 6.3 7 0 0 7 7 7 0 Fis1 C-terminal tetratricopeptide repeat TPR_10 PF13374.6 EMD67625.1 - 0.16 11.9 27.2 0.78 9.7 0.2 8.6 9 1 0 9 9 9 0 Tetratricopeptide repeat Sec8_exocyst PF04048.14 EMD67627.1 - 1.5e-46 157.9 7.0 2.3e-46 157.2 3.5 2.6 2 0 0 2 2 2 1 Sec8 exocyst complex component specific domain Vps54_N PF10475.9 EMD67627.1 - 4e-10 39.5 4.8 4e-10 39.5 4.8 1.7 2 0 0 2 2 2 1 Vacuolar-sorting protein 54, of GARP complex Zw10 PF06248.13 EMD67627.1 - 8.7e-05 21.3 3.7 0.00014 20.6 3.7 1.3 1 0 0 1 1 1 1 Centromere/kinetochore Zw10 COG2 PF06148.11 EMD67627.1 - 0.0029 17.7 1.1 0.013 15.6 1.1 2.2 1 0 0 1 1 1 1 COG (conserved oligomeric Golgi) complex component, COG2 KxDL PF10241.9 EMD67627.1 - 0.031 14.6 0.8 0.14 12.4 0.8 2.2 1 0 0 1 1 1 0 Uncharacterized conserved protein HIP1_clath_bdg PF16515.5 EMD67627.1 - 0.11 13.1 2.5 0.65 10.6 2.5 2.4 1 0 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Vps51 PF08700.11 EMD67627.1 - 0.14 12.2 2.4 1.3 9.2 0.9 3.1 2 0 0 2 2 2 0 Vps51/Vps67 FliJ PF02050.16 EMD67627.1 - 0.22 11.8 4.4 0.72 10.1 4.4 2.0 1 0 0 1 1 1 0 Flagellar FliJ protein Exonuc_VII_L PF02601.15 EMD67627.1 - 0.57 9.7 9.4 0.31 10.6 4.4 2.4 2 0 0 2 2 2 0 Exonuclease VII, large subunit ABC_tran PF00005.27 EMD67628.1 - 3.4e-27 95.6 0.0 5.2e-27 95.0 0.0 1.3 1 0 0 1 1 1 1 ABC transporter ABC2_membrane PF01061.24 EMD67628.1 - 9.4e-26 90.5 27.0 9.4e-26 90.5 27.0 1.4 2 0 0 2 2 1 1 ABC-2 type transporter AAA_21 PF13304.6 EMD67628.1 - 1.8e-06 28.0 0.0 0.0085 15.9 0.0 2.2 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 EMD67628.1 - 2.8e-06 27.3 0.1 1.1e-05 25.4 0.0 1.9 2 0 0 2 2 2 1 RsgA GTPase AAA_25 PF13481.6 EMD67628.1 - 7.5e-05 22.4 0.2 0.00018 21.1 0.0 1.6 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EMD67628.1 - 0.0002 21.8 0.1 0.00036 21.0 0.1 1.5 1 0 0 1 1 1 1 AAA ATPase domain ABC2_membrane_3 PF12698.7 EMD67628.1 - 0.00023 20.4 21.2 0.0023 17.1 21.2 2.1 1 1 0 1 1 1 1 ABC-2 family transporter protein SMC_N PF02463.19 EMD67628.1 - 0.0011 18.4 0.0 0.0047 16.4 0.0 1.8 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 EMD67628.1 - 0.002 18.4 0.0 0.0053 17.0 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 EMD67628.1 - 0.011 15.5 0.0 0.025 14.3 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain NACHT PF05729.12 EMD67628.1 - 0.025 14.5 0.0 0.053 13.4 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA PF00004.29 EMD67628.1 - 0.026 14.9 0.1 0.16 12.4 0.1 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_13 PF13166.6 EMD67628.1 - 0.03 13.0 0.1 0.29 9.7 0.0 2.0 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 EMD67628.1 - 0.032 13.8 0.0 0.06 12.9 0.0 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain IstB_IS21 PF01695.17 EMD67628.1 - 0.037 13.7 0.0 0.1 12.4 0.0 1.7 1 0 0 1 1 1 0 IstB-like ATP binding protein Rad17 PF03215.15 EMD67628.1 - 0.039 13.9 0.0 0.09 12.7 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_33 PF13671.6 EMD67628.1 - 0.049 13.8 0.0 0.11 12.7 0.0 1.6 2 0 0 2 2 1 0 AAA domain AAA_18 PF13238.6 EMD67628.1 - 0.051 14.1 0.0 0.13 12.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 EMD67628.1 - 0.054 12.5 0.0 0.09 11.8 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein SbcCD_C PF13558.6 EMD67628.1 - 0.074 13.3 0.0 0.21 11.9 0.0 1.8 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_30 PF13604.6 EMD67628.1 - 0.077 12.7 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 EMD67628.1 - 0.13 12.5 0.0 0.22 11.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 EMD67628.1 - 0.14 12.2 0.0 0.5 10.4 0.0 1.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 EMD67628.1 - 0.15 12.1 0.0 0.3 11.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 EMD67628.1 - 0.22 10.6 0.3 0.93 8.6 0.0 1.9 2 0 0 2 2 2 0 NB-ARC domain AAA_24 PF13479.6 EMD67628.1 - 0.25 11.0 0.3 0.62 9.7 0.0 1.8 2 0 0 2 2 2 0 AAA domain APH PF01636.23 EMD67630.1 - 4.4e-15 56.2 0.1 8.9e-15 55.3 0.1 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family DUF1679 PF07914.11 EMD67630.1 - 2.1e-06 26.9 0.0 3e-06 26.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1679) EcKinase PF02958.20 EMD67630.1 - 9.2e-06 25.2 0.0 2.3e-05 23.8 0.0 1.5 1 1 0 1 1 1 1 Ecdysteroid kinase Choline_kinase PF01633.20 EMD67630.1 - 0.00032 20.4 0.0 0.0014 18.3 0.0 1.9 1 1 0 1 1 1 1 Choline/ethanolamine kinase Kdo PF06293.14 EMD67630.1 - 0.092 12.1 0.0 0.19 11.1 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Cation_efflux PF01545.21 EMD67632.1 - 4.7e-23 82.0 5.2 5.9e-23 81.6 5.2 1.1 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 EMD67632.1 - 2e-05 24.7 0.0 5.3e-05 23.3 0.0 1.8 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter YkuI_C PF10388.9 EMD67632.1 - 0.08 12.8 0.2 0.15 11.8 0.2 1.4 1 0 0 1 1 1 0 EAL-domain associated signalling protein domain DnaJ_C PF01556.18 EMD67635.1 - 3.2e-34 118.2 0.5 4.3e-34 117.7 0.5 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EMD67635.1 - 1.9e-28 98.3 2.4 3.5e-28 97.5 2.4 1.4 1 0 0 1 1 1 1 DnaJ domain DKCLD PF08068.12 EMD67636.1 - 3.1e-32 110.4 0.2 6.5e-31 106.2 0.3 2.4 2 0 0 2 2 2 1 DKCLD (NUC011) domain TruB_C_2 PF16198.5 EMD67636.1 - 3e-23 81.7 0.8 6e-23 80.8 0.8 1.5 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain TruB_N PF01509.18 EMD67636.1 - 3.5e-23 82.6 1.2 2.9e-20 73.1 0.3 3.7 2 1 0 2 2 2 1 TruB family pseudouridylate synthase (N terminal domain) PUA PF01472.20 EMD67636.1 - 3.3e-19 68.6 0.8 6.3e-19 67.7 0.8 1.5 1 0 0 1 1 1 1 PUA domain UPF0113 PF03657.13 EMD67636.1 - 0.044 14.0 0.0 0.11 12.8 0.0 1.6 1 0 0 1 1 1 0 UPF0113 PUA domain CDC45 PF02724.14 EMD67636.1 - 0.74 8.0 11.3 1.3 7.3 11.3 1.3 1 0 0 1 1 1 0 CDC45-like protein TENA_THI-4 PF03070.16 EMD67637.1 - 1.9e-06 27.8 0.0 1.1e-05 25.4 0.0 2.0 1 1 0 1 1 1 1 TENA/THI-4/PQQC family adh_short PF00106.25 EMD67638.1 - 3.6e-21 75.5 0.2 5.3e-21 75.0 0.2 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD67638.1 - 1.2e-18 67.5 0.1 1.8e-18 67.0 0.1 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD67638.1 - 6.4e-09 36.0 0.1 8.3e-09 35.6 0.1 1.2 1 0 0 1 1 1 1 KR domain BAR PF03114.18 EMD67639.1 - 2.2e-61 207.6 4.1 2.6e-61 207.3 4.1 1.1 1 0 0 1 1 1 1 BAR domain FliD_N PF02465.18 EMD67639.1 - 0.31 11.8 5.0 1.4 9.7 0.4 2.7 3 0 0 3 3 3 0 Flagellar hook-associated protein 2 N-terminus tRNA-synt_1b PF00579.25 EMD67640.1 - 2.1e-67 227.5 0.0 2.8e-67 227.1 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) DUF883 PF05957.13 EMD67640.1 - 0.7 10.5 3.9 1.5 9.5 3.9 1.5 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF883) UQ_con PF00179.26 EMD67641.1 - 5.2e-38 129.9 0.1 7.1e-38 129.4 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UFC1 PF08694.11 EMD67641.1 - 0.029 14.0 0.0 0.053 13.2 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-fold modifier-conjugating enzyme 1 RWD PF05773.22 EMD67641.1 - 0.089 13.1 0.4 0.27 11.5 0.4 2.0 1 1 0 1 1 1 0 RWD domain NOA36 PF06524.12 EMD67641.1 - 2.4 7.4 10.7 3 7.1 10.7 1.1 1 0 0 1 1 1 0 NOA36 protein CorA PF01544.18 EMD67642.1 - 2.7e-47 161.5 0.0 3.8e-47 161.0 0.0 1.2 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein SPC12 PF06645.13 EMD67643.1 - 4e-30 103.7 0.1 4.7e-30 103.5 0.1 1.1 1 0 0 1 1 1 1 Microsomal signal peptidase 12 kDa subunit (SPC12) DUF3040 PF11239.8 EMD67643.1 - 0.045 14.0 1.5 0.056 13.7 1.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) ZYG-11_interact PF05884.12 EMD67643.1 - 0.12 11.8 0.1 0.14 11.6 0.1 1.1 1 0 0 1 1 1 0 Interactor of ZYG-11 zf-rbx1 PF12678.7 EMD67644.1 - 2.6e-25 88.5 13.1 3.5e-25 88.1 13.1 1.2 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 EMD67644.1 - 3.1e-17 62.4 10.0 3.9e-17 62.1 10.0 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.6 EMD67644.1 - 1.7e-06 28.2 14.5 6.6e-05 23.2 14.5 2.2 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EMD67644.1 - 8.3e-05 22.4 3.5 8.3e-05 22.4 3.5 2.3 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMD67644.1 - 0.0012 18.7 11.9 0.022 14.6 11.9 2.5 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EMD67644.1 - 0.13 12.1 10.8 0.44 10.5 4.5 2.6 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EMD67644.1 - 0.26 11.0 15.8 24 4.8 15.8 2.4 1 1 0 1 1 1 0 RING-like zinc finger zf-RING_UBOX PF13445.6 EMD67644.1 - 0.41 10.7 7.8 1.5 8.9 7.8 2.0 1 1 0 1 1 1 0 RING-type zinc-finger FANCL_C PF11793.8 EMD67644.1 - 0.46 10.7 9.4 2.4 8.4 9.5 1.9 1 1 1 2 2 2 0 FANCL C-terminal domain Zn_ribbon_17 PF17120.5 EMD67644.1 - 0.51 10.0 14.9 80 3.0 14.9 2.3 1 1 0 1 1 1 0 Zinc-ribbon, C4HC2 type PNRC PF15365.6 EMD67645.1 - 6.3e-09 35.4 5.5 6.3e-09 35.4 5.5 3.8 4 0 0 4 4 4 1 Proline-rich nuclear receptor coactivator motif DUF5541 PF17695.1 EMD67645.1 - 0.073 13.5 0.1 0.17 12.3 0.1 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5541) Pkinase PF00069.25 EMD67647.1 - 4.2e-68 229.6 0.6 4.3e-67 226.3 0.6 2.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD67647.1 - 2.8e-54 184.1 0.0 5.6e-54 183.1 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 EMD67647.1 - 4.7e-22 78.1 0.0 1.7e-21 76.4 0.0 2.0 1 0 0 1 1 1 1 P21-Rho-binding domain PH PF00169.29 EMD67647.1 - 2.8e-07 31.0 0.0 6e-07 29.9 0.0 1.6 1 0 0 1 1 1 1 PH domain Pkinase_fungal PF17667.1 EMD67647.1 - 9.3e-06 24.7 0.0 9.3e-06 24.7 0.0 2.8 3 0 0 3 3 3 1 Fungal protein kinase Kinase-like PF14531.6 EMD67647.1 - 6.6e-05 22.4 0.0 0.00011 21.7 0.0 1.4 1 0 0 1 1 1 1 Kinase-like PH_11 PF15413.6 EMD67647.1 - 9.8e-05 22.7 0.0 0.00038 20.8 0.0 2.1 1 0 0 1 1 1 1 Pleckstrin homology domain Haspin_kinase PF12330.8 EMD67647.1 - 0.00073 18.6 0.0 0.0011 18.0 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain CH PF00307.31 EMD67648.1 - 1.1e-47 160.8 0.1 2.9e-23 82.1 0.0 2.9 3 0 0 3 3 3 2 Calponin homology (CH) domain EFhand_Ca_insen PF08726.10 EMD67648.1 - 6.6e-28 96.6 2.2 2e-25 88.7 0.2 2.7 2 0 0 2 2 2 2 Ca2+ insensitive EF hand CAMSAP_CH PF11971.8 EMD67648.1 - 1.8e-11 43.7 0.2 4.7e-07 29.5 0.1 2.9 2 0 0 2 2 2 2 CAMSAP CH domain CH_2 PF06294.11 EMD67648.1 - 0.0034 17.4 0.1 0.07 13.3 0.0 2.7 2 0 0 2 2 2 1 CH-like domain in sperm protein EF-hand_6 PF13405.6 EMD67648.1 - 0.01 15.7 0.6 0.22 11.5 0.0 3.2 3 0 0 3 3 3 0 EF-hand domain DUF2884 PF11101.8 EMD67648.1 - 0.029 13.9 0.2 0.029 13.9 0.2 2.6 2 1 0 3 3 3 0 Protein of unknown function (DUF2884) NADH-UOR_E PF16514.5 EMD67648.1 - 0.047 14.0 0.3 0.77 10.1 0.1 3.0 2 1 0 2 2 2 0 putative NADH-ubiquinone oxidoreductase chain E EF-hand_1 PF00036.32 EMD67648.1 - 0.069 12.7 0.3 1.8 8.3 0.0 2.7 2 0 0 2 2 2 0 EF hand DHR10 PF18595.1 EMD67648.1 - 0.088 12.9 4.5 3 7.9 0.2 2.5 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain EF-hand_8 PF13833.6 EMD67648.1 - 0.09 12.6 0.5 0.78 9.6 0.0 2.7 2 1 1 3 3 3 0 EF-hand domain pair Baculo_PEP_C PF04513.12 EMD67648.1 - 0.12 12.5 3.3 0.23 11.5 1.5 2.4 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus EF-hand_7 PF13499.6 EMD67648.1 - 0.25 11.8 3.8 0.27 11.7 1.3 2.5 2 0 0 2 2 2 0 EF-hand domain pair DUF4508 PF14969.6 EMD67648.1 - 0.7 10.2 3.8 2.7 8.3 0.4 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4508) FliG_N PF14842.6 EMD67648.1 - 0.99 10.0 3.3 1.7 9.2 0.2 2.8 3 1 0 3 3 2 0 FliG N-terminal domain Kinase-PPPase PF03618.14 EMD67649.1 - 0.088 12.6 0.0 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 Kinase/pyrophosphorylase Allexi_40kDa PF05549.11 EMD67649.1 - 0.11 11.9 0.0 0.29 10.6 0.0 1.6 1 0 0 1 1 1 0 Allexivirus 40kDa protein DNA_pol3_delt_C PF14840.6 EMD67649.1 - 0.16 12.3 0.5 0.84 10.0 0.4 2.1 1 1 1 2 2 2 0 Processivity clamp loader gamma complex DNA pol III C-term Rsa3 PF14615.6 EMD67649.1 - 0.19 11.3 0.9 0.51 10.0 0.1 2.0 2 0 0 2 2 2 0 Ribosome-assembly protein 3 Tom7 PF08038.12 EMD67650.1 - 1.9e-22 78.6 0.1 2.2e-22 78.4 0.1 1.1 1 0 0 1 1 1 1 TOM7 family RRM_1 PF00076.22 EMD67651.1 - 2.8e-32 110.3 0.0 4.1e-16 58.6 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EMD67651.1 - 0.00011 22.2 0.0 0.00023 21.2 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif RRM_5 PF13893.6 EMD67651.1 - 0.00078 19.0 0.1 0.11 12.1 0.0 2.2 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 EMD67651.1 - 0.0062 16.6 0.2 0.18 11.9 0.0 2.2 2 0 0 2 2 2 1 Limkain b1 Cas_Cas2CT1978 PF09707.10 EMD67651.1 - 0.071 13.2 0.0 2.7 8.1 0.0 2.2 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_Cas2CT1978) PHM7_cyt PF14703.6 EMD67651.1 - 0.078 13.2 0.2 14 5.9 0.0 2.1 2 0 0 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter OB_RNB PF08206.11 EMD67651.1 - 0.18 11.5 0.6 2.9 7.6 0.0 2.3 2 0 0 2 2 2 0 Ribonuclease B OB domain DUF2015 PF09435.10 EMD67652.1 - 1.1e-46 157.3 0.0 1.2e-46 157.1 0.0 1.0 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF2015) Ribosomal_L28e PF01778.17 EMD67653.1 - 9e-30 103.8 0.3 1.1e-29 103.5 0.3 1.1 1 0 0 1 1 1 1 Ribosomal L28e protein family Med3 PF11593.8 EMD67653.1 - 0.82 8.8 11.7 0.99 8.5 11.7 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Patatin PF01734.22 EMD67655.1 - 1.1e-08 35.5 0.0 3.2e-08 34.0 0.0 1.8 2 0 0 2 2 2 1 Patatin-like phospholipase gag-asp_proteas PF13975.6 EMD67656.1 - 0.02 15.5 0.1 0.53 10.9 0.1 2.3 2 0 0 2 2 2 0 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 EMD67656.1 - 0.024 15.3 0.2 0.94 10.2 0.1 2.4 2 0 0 2 2 2 0 Aspartyl protease Haem_degrading PF03928.14 EMD67657.1 - 1.8e-29 102.2 0.0 2.2e-29 101.9 0.0 1.1 1 0 0 1 1 1 1 Haem-degrading HATPase_c PF02518.26 EMD67658.1 - 1.4e-24 86.7 0.1 2.8e-24 85.8 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EMD67658.1 - 6.6e-19 68.1 0.1 1.6e-18 66.9 0.1 1.7 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 EMD67658.1 - 3.1e-10 39.9 1.9 4.4e-10 39.4 0.2 2.2 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain PAS_4 PF08448.10 EMD67658.1 - 0.0005 20.3 0.1 0.064 13.5 0.0 2.8 2 0 0 2 2 2 1 PAS fold MazG PF03819.17 EMD67658.1 - 0.00094 19.3 0.2 0.0024 18.0 0.2 1.7 1 0 0 1 1 1 1 MazG nucleotide pyrophosphohydrolase domain PAS_3 PF08447.12 EMD67658.1 - 0.0016 18.6 0.0 0.005 17.1 0.0 1.8 1 0 0 1 1 1 1 PAS fold IF-2B PF01008.17 EMD67658.1 - 0.0046 16.2 0.5 0.0084 15.3 0.5 1.3 1 0 0 1 1 1 1 Initiation factor 2 subunit family PAS_9 PF13426.7 EMD67658.1 - 0.064 13.5 0.0 0.25 11.6 0.0 2.1 1 0 0 1 1 1 0 PAS domain PAS PF00989.25 EMD67658.1 - 0.086 12.8 0.0 0.36 10.8 0.0 2.2 1 0 0 1 1 1 0 PAS fold adh_short_C2 PF13561.6 EMD67659.1 - 2e-64 217.4 0.0 2.5e-64 217.1 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EMD67659.1 - 1.6e-52 177.8 0.1 2.1e-52 177.5 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EMD67659.1 - 3.1e-11 43.5 0.2 6e-11 42.6 0.2 1.4 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 EMD67659.1 - 0.0098 15.4 0.0 0.016 14.7 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 2-Hacid_dh_C PF02826.19 EMD67659.1 - 0.049 13.0 0.0 0.14 11.5 0.0 1.7 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Ldh_1_N PF00056.23 EMD67659.1 - 0.075 13.1 0.1 0.12 12.5 0.1 1.4 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain ADH_zinc_N PF00107.26 EMD67659.1 - 0.088 12.8 0.0 0.17 11.9 0.0 1.4 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Torus PF16131.5 EMD67660.1 - 2.5e-44 150.4 0.1 2.5e-44 150.4 0.1 2.6 3 0 0 3 3 3 1 Torus domain RRM_1 PF00076.22 EMD67660.1 - 9.2e-07 28.6 0.0 1.7e-06 27.8 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf_CCCH_4 PF18345.1 EMD67660.1 - 0.00015 21.7 0.4 0.00015 21.7 0.4 1.8 2 0 0 2 2 2 1 Zinc finger domain zf-CCCH PF00642.24 EMD67660.1 - 0.001 18.9 0.4 0.0018 18.1 0.4 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Nup35_RRM_2 PF14605.6 EMD67660.1 - 0.016 15.2 0.0 0.029 14.4 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Peptidase_C78 PF07910.13 EMD67661.1 - 6.7e-61 205.5 0.0 9.9e-61 204.9 0.0 1.2 1 0 0 1 1 1 1 Peptidase family C78 MaoC_dehydratas PF01575.19 EMD67662.1 - 0.07 12.7 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 MaoC like domain Helo_like_N PF17111.5 EMD67664.1 - 4.3e-06 26.2 0.1 8.8e-06 25.2 0.1 1.5 1 0 0 1 1 1 1 Fungal N-terminal domain of STAND proteins SesA PF17107.5 EMD67664.1 - 1.1e-05 25.7 0.9 2.8e-05 24.3 0.3 2.0 2 0 0 2 2 2 1 N-terminal domain on NACHT_NTPase and P-loop NTPases Filament PF00038.21 EMD67664.1 - 0.057 13.0 0.0 0.1 12.2 0.0 1.3 1 0 0 1 1 1 0 Intermediate filament protein CorA PF01544.18 EMD67666.1 - 0.00055 19.3 3.5 0.0011 18.4 1.8 2.1 1 1 1 2 2 2 1 CorA-like Mg2+ transporter protein Cpn60_TCP1 PF00118.24 EMD67667.1 - 8.9e-89 298.3 13.6 1.5e-88 297.6 13.6 1.3 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family Rrf2 PF02082.20 EMD67667.1 - 0.066 13.6 0.1 0.19 12.1 0.1 1.8 1 0 0 1 1 1 0 Transcriptional regulator Cofilin_ADF PF00241.20 EMD67668.1 - 1.1e-37 128.5 0.2 1.2e-37 128.3 0.2 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Blt1 PF12754.7 EMD67669.1 - 4.5e-51 173.1 0.5 6.8e-51 172.5 0.5 1.3 1 0 0 1 1 1 1 Blt1 N-terminal domain Blt1_C PF17183.4 EMD67669.1 - 4.3e-17 61.4 0.2 7.4e-17 60.7 0.2 1.4 1 0 0 1 1 1 1 Get5 carboxyl domain ubiquitin PF00240.23 EMD67669.1 - 0.0021 17.8 0.0 0.0035 17.1 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family Methyltr_RsmB-F PF01189.17 EMD67670.1 - 3.3e-76 255.4 0.0 5.3e-76 254.7 0.0 1.3 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltr_RsmF_N PF17125.5 EMD67670.1 - 1.4e-08 35.1 0.0 3.9e-08 33.7 0.0 1.8 1 0 0 1 1 1 1 N-terminal domain of 16S rRNA methyltransferase RsmF FtsJ PF01728.19 EMD67670.1 - 0.018 15.1 0.0 0.034 14.2 0.0 1.4 1 0 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_31 PF13847.6 EMD67670.1 - 0.035 13.9 0.0 0.081 12.7 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain DUF2431 PF10354.9 EMD67670.1 - 0.054 13.8 0.0 0.095 13.0 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2431) Sugar_tr PF00083.24 EMD67671.1 - 1.9e-123 412.7 19.7 2.2e-123 412.5 19.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD67671.1 - 7.4e-18 64.6 31.3 1.3e-17 63.8 26.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Ilm1 PF10311.9 EMD67671.1 - 0.15 11.7 0.6 0.28 10.8 0.6 1.5 1 0 0 1 1 1 0 Increased loss of mitochondrial DNA protein 1 Cation_ATPase_C PF00689.21 EMD67671.1 - 4.7 6.9 15.0 0.85 9.3 6.3 3.5 3 1 0 3 3 3 0 Cation transporting ATPase, C-terminus Opi1 PF08618.10 EMD67675.1 - 0.014 14.7 0.1 0.019 14.2 0.1 1.1 1 0 0 1 1 1 0 Transcription factor Opi1 bZIP_2 PF07716.15 EMD67677.1 - 2.5e-09 37.1 14.9 4.8e-09 36.2 14.9 1.5 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 EMD67677.1 - 0.00028 20.9 16.7 0.00057 19.9 16.3 1.7 1 1 0 1 1 1 1 bZIP transcription factor HAP1_N PF04849.13 EMD67677.1 - 0.0076 15.5 8.3 0.011 14.9 8.3 1.2 1 0 0 1 1 1 1 HAP1 N-terminal conserved region Di19_C PF14571.6 EMD67677.1 - 0.04 14.5 1.6 0.081 13.5 1.6 1.6 1 0 0 1 1 1 0 Stress-induced protein Di19, C-terminal DUF3450 PF11932.8 EMD67677.1 - 0.1 11.9 6.2 0.16 11.3 6.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Jnk-SapK_ap_N PF09744.9 EMD67677.1 - 0.14 12.4 12.0 0.26 11.5 12.0 1.4 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 YabA PF06156.13 EMD67677.1 - 0.15 12.7 8.0 0.22 12.2 6.7 2.0 2 1 0 2 2 2 0 Initiation control protein YabA DUF5094 PF17015.5 EMD67677.1 - 0.15 12.1 6.5 0.22 11.6 6.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5094) DUF3552 PF12072.8 EMD67677.1 - 1.1 8.7 15.8 1.5 8.2 15.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) Seryl_tRNA_N PF02403.22 EMD67677.1 - 2.2 8.6 11.8 2.2 8.5 10.7 1.6 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Ribosomal_L30_N PF08079.12 EMD67677.1 - 3.3 8.0 13.7 5.3 7.4 13.7 1.4 1 0 0 1 1 1 0 Ribosomal L30 N-terminal domain ADH_zinc_N_2 PF13602.6 EMD67678.1 - 1.2e-24 87.9 0.1 3.3e-24 86.4 0.0 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 EMD67678.1 - 1.4e-15 57.4 0.1 2.5e-15 56.6 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EMD67678.1 - 8.7e-07 28.8 0.0 2.2e-06 27.5 0.0 1.8 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain AlaDh_PNT_C PF01262.21 EMD67678.1 - 0.0099 15.2 0.1 0.015 14.6 0.1 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Etmic-2 PF06670.11 EMD67678.1 - 0.041 12.8 0.4 0.057 12.3 0.4 1.2 1 0 0 1 1 1 0 Microneme protein Etmic-2 FSIP2 PF15783.5 EMD67678.1 - 0.21 9.5 0.0 0.28 9.1 0.0 1.0 1 0 0 1 1 1 0 Fibrous sheath-interacting protein 2 Abhydrolase_1 PF00561.20 EMD67680.1 - 5.5e-23 81.9 0.0 3.3e-22 79.4 0.0 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EMD67680.1 - 3.1e-12 47.6 0.0 5.1e-12 46.9 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EMD67680.1 - 8.1e-10 38.4 0.0 1.4e-09 37.6 0.0 1.6 1 1 0 1 1 1 1 Serine aminopeptidase, S33 PGAP1 PF07819.13 EMD67680.1 - 0.00032 20.5 0.1 0.19 11.5 0.1 2.2 1 1 1 2 2 2 2 PGAP1-like protein DUF676 PF05057.14 EMD67680.1 - 0.001 18.6 0.0 0.0016 18.0 0.0 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Palm_thioest PF02089.15 EMD67680.1 - 0.0078 16.1 0.0 0.011 15.6 0.0 1.2 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Thioesterase PF00975.20 EMD67680.1 - 0.017 15.3 0.0 0.028 14.5 0.0 1.3 1 0 0 1 1 1 0 Thioesterase domain Ndr PF03096.14 EMD67680.1 - 0.03 13.0 0.0 0.19 10.4 0.0 1.9 2 0 0 2 2 2 0 Ndr family Esterase PF00756.20 EMD67680.1 - 0.043 13.5 0.0 0.063 12.9 0.0 1.2 1 0 0 1 1 1 0 Putative esterase Chlorophyllase2 PF12740.7 EMD67680.1 - 0.046 12.6 0.0 0.093 11.6 0.0 1.4 1 1 0 1 1 1 0 Chlorophyllase enzyme LCAT PF02450.15 EMD67680.1 - 0.059 12.5 0.0 0.091 11.9 0.0 1.2 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase DUF915 PF06028.11 EMD67680.1 - 0.17 11.2 0.1 4.5 6.5 0.0 2.3 1 1 1 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF915) SARAF PF06682.12 EMD67681.1 - 1.1e-107 360.5 6.9 1.3e-107 360.3 6.9 1.0 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis PIG-X PF08320.12 EMD67682.1 - 2.4e-64 217.2 0.0 4.7e-64 216.2 0.0 1.5 2 0 0 2 2 2 1 PIG-X / PBN1 ThiF PF00899.21 EMD67683.1 - 1.8e-29 102.8 0.0 2.4e-29 102.4 0.0 1.1 1 0 0 1 1 1 1 ThiF family HET PF06985.11 EMD67685.1 - 5.9e-22 78.6 0.1 7.2e-22 78.3 0.1 1.1 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) DUF815 PF05673.13 EMD67685.1 - 0.011 14.9 0.0 0.013 14.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF815) DUF3564 PF12087.8 EMD67685.1 - 0.13 12.2 0.0 0.27 11.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3564) Tir_receptor_N PF07490.11 EMD67686.1 - 0.0035 17.2 1.3 0.0046 16.8 1.3 1.2 1 0 0 1 1 1 1 Translocated intimin receptor (Tir) N-terminus DUF4419 PF14388.6 EMD67686.1 - 0.038 13.4 0.3 0.062 12.7 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4419) DPBB_1 PF03330.18 EMD67687.1 - 3e-10 40.2 0.9 4.6e-09 36.4 0.0 2.6 2 0 0 2 2 2 1 Lytic transglycolase Barwin PF00967.17 EMD67687.1 - 0.0071 16.2 2.2 0.02 14.7 0.0 2.5 3 0 0 3 3 3 1 Barwin family BNR PF02012.20 EMD67687.1 - 0.098 12.7 0.6 0.098 12.7 0.6 2.4 2 0 0 2 2 2 0 BNR/Asp-box repeat Bmt2 PF11968.8 EMD67688.1 - 8.3e-87 290.6 0.0 1.1e-86 290.3 0.0 1.1 1 0 0 1 1 1 1 25S rRNA (adenine(2142)-N(1))-methyltransferase, Bmt2 Methyltransf_23 PF13489.6 EMD67688.1 - 0.013 15.3 0.0 0.029 14.2 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase domain Ribosomal_L23eN PF03939.13 EMD67689.1 - 3.3e-24 84.9 8.4 7.1e-24 83.8 8.4 1.6 1 0 0 1 1 1 1 Ribosomal protein L23, N-terminal domain Ribosomal_L23 PF00276.20 EMD67689.1 - 3.9e-13 49.6 0.4 3.9e-13 49.6 0.4 1.6 2 0 0 2 2 2 1 Ribosomal protein L23 Rhodanese PF00581.20 EMD67689.1 - 0.12 12.9 0.1 0.21 12.1 0.0 1.5 1 1 0 1 1 1 0 Rhodanese-like domain zf-Tim10_DDP PF02953.15 EMD67690.1 - 1.6e-20 72.5 0.2 2.9e-20 71.7 0.2 1.4 1 0 0 1 1 1 1 Tim10/DDP family zinc finger Aa_trans PF01490.18 EMD67691.1 - 8.8e-60 202.5 28.6 1.1e-59 202.2 28.6 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein MerC PF03203.14 EMD67691.1 - 0.006 17.0 3.6 0.006 17.0 3.6 3.2 2 1 0 2 2 2 1 MerC mercury resistance protein eRF1_2 PF03464.15 EMD67692.1 - 7.2e-48 162.3 0.1 1.2e-47 161.5 0.1 1.4 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 EMD67692.1 - 1.1e-39 135.4 0.3 2.5e-39 134.3 0.3 1.6 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_1 PF03463.15 EMD67692.1 - 3.1e-21 75.7 0.0 5.4e-21 74.9 0.0 1.4 1 0 0 1 1 1 1 eRF1 domain 1 baeRF_family10 PF18854.1 EMD67692.1 - 6.7e-10 39.4 0.0 1.2e-09 38.6 0.0 1.3 1 0 0 1 1 1 1 Bacterial archaeo-eukaryotic release factor family 10 acVLRF1 PF18859.1 EMD67692.1 - 6.6e-09 36.1 0.0 1e-08 35.5 0.0 1.3 1 0 0 1 1 1 1 Actinobacteria/chloroflexi VLRF1 release factor PDT PF00800.18 EMD67693.1 - 3.4e-59 199.7 0.0 4.4e-59 199.4 0.0 1.1 1 0 0 1 1 1 1 Prephenate dehydratase ACT PF01842.25 EMD67693.1 - 5e-07 29.4 0.0 1.9e-06 27.5 0.0 2.0 2 1 0 2 2 2 1 ACT domain Ras PF00071.22 EMD67694.1 - 1.8e-44 151.2 0.2 3.7e-44 150.2 0.2 1.5 1 0 0 1 1 1 1 Ras family tRNA-synt_2b PF00587.25 EMD67694.1 - 1e-33 116.8 0.0 2.2e-33 115.7 0.0 1.6 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Roc PF08477.13 EMD67694.1 - 3.4e-14 53.1 0.1 8.2e-14 51.8 0.1 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Seryl_tRNA_N PF02403.22 EMD67694.1 - 1e-07 32.1 8.6 2.5e-07 30.9 8.6 1.7 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain Arf PF00025.21 EMD67694.1 - 4.7e-07 29.4 0.0 8.9e-07 28.5 0.0 1.5 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EMD67694.1 - 0.0015 18.0 0.0 0.0015 18.0 0.0 2.2 3 0 0 3 3 3 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 EMD67694.1 - 0.013 15.6 0.0 0.036 14.2 0.0 1.8 1 0 0 1 1 1 0 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EMD67694.1 - 0.015 14.9 1.0 0.039 13.5 0.0 1.8 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_14 PF13173.6 EMD67694.1 - 0.069 13.2 0.1 0.21 11.6 0.1 1.9 1 0 0 1 1 1 0 AAA domain DUF3698 PF12479.8 EMD67694.1 - 0.086 13.4 0.1 0.51 10.9 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3698) WAPL PF07814.13 EMD67695.1 - 5.4e-70 236.0 8.6 1e-69 235.1 8.6 1.5 1 0 0 1 1 1 1 Wings apart-like protein regulation of heterochromatin UPRTase PF14681.6 EMD67696.1 - 4.8e-82 274.4 0.0 6.7e-82 273.9 0.0 1.0 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.27 EMD67696.1 - 0.0037 16.8 0.0 0.0051 16.3 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain Elf1 PF05129.13 EMD67697.1 - 4.2e-31 106.8 0.6 5.7e-31 106.4 0.6 1.2 1 0 0 1 1 1 1 Transcription elongation factor Elf1 like PHD_4 PF16866.5 EMD67697.1 - 0.018 15.1 0.4 0.032 14.3 0.4 1.4 1 0 0 1 1 1 0 PHD-finger zf-Sec23_Sec24 PF04810.15 EMD67697.1 - 0.046 13.8 1.8 0.51 10.4 0.2 2.2 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger Zn-ribbon_8 PF09723.10 EMD67697.1 - 0.11 12.6 0.4 0.22 11.7 0.4 1.5 1 0 0 1 1 1 0 Zinc ribbon domain Cys_rich_CPXG PF14255.6 EMD67697.1 - 0.26 11.2 1.4 0.78 9.7 0.9 2.0 1 1 0 1 1 1 0 Cysteine-rich CPXCG zf-LITAF-like PF10601.9 EMD67697.1 - 0.36 11.1 3.0 6.5 7.1 0.3 2.3 1 1 1 2 2 2 0 LITAF-like zinc ribbon domain GTP_CH_N PF12471.8 EMD67698.1 - 1.2e-92 309.0 0.0 1.8e-92 308.5 0.0 1.3 1 0 0 1 1 1 1 GTP cyclohydrolase N terminal GTP_cyclohydro2 PF00925.20 EMD67698.1 - 2.5e-17 63.0 0.0 3.7e-17 62.4 0.0 1.3 1 0 0 1 1 1 1 GTP cyclohydrolase II Ribosomal_S3Ae PF01015.18 EMD67700.1 - 4.4e-89 297.4 4.9 5.5e-89 297.1 4.9 1.0 1 0 0 1 1 1 1 Ribosomal S3Ae family NEMO PF11577.8 EMD67700.1 - 0.06 13.4 0.6 0.41 10.7 0.0 2.3 2 0 0 2 2 2 0 NF-kappa-B essential modulator NEMO p450 PF00067.22 EMD67703.1 - 0.06 12.1 0.0 0.37 9.5 0.0 2.0 2 0 0 2 2 2 0 Cytochrome P450 HIRA_B PF09453.10 EMD67703.1 - 0.15 12.0 0.9 0.27 11.1 0.9 1.5 1 0 0 1 1 1 0 HIRA B motif Ham1p_like PF01725.16 EMD67704.1 - 3.4e-60 203.2 0.0 3.8e-60 203.0 0.0 1.0 1 0 0 1 1 1 1 Ham1 family AAA_18 PF13238.6 EMD67705.1 - 2.2e-26 93.0 0.0 3.7e-26 92.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 EMD67705.1 - 4e-07 30.5 0.8 7.1e-06 26.5 0.1 2.5 1 1 1 2 2 2 1 AAA domain AAA_33 PF13671.6 EMD67705.1 - 3.3e-06 27.3 0.1 0.00012 22.3 0.1 2.2 1 1 0 2 2 2 1 AAA domain ADK PF00406.22 EMD67705.1 - 1e-05 25.7 0.1 0.0012 19.0 0.0 2.2 2 0 0 2 2 2 1 Adenylate kinase AAA_28 PF13521.6 EMD67705.1 - 4.3e-05 23.8 2.4 6.5e-05 23.2 0.0 2.3 2 1 0 2 2 2 1 AAA domain dNK PF01712.19 EMD67705.1 - 0.00011 22.1 0.2 0.054 13.3 0.0 2.1 2 0 0 2 2 2 2 Deoxynucleoside kinase KTI12 PF08433.10 EMD67705.1 - 0.00013 21.5 0.0 0.0003 20.3 0.0 1.5 2 0 0 2 2 2 1 Chromatin associated protein KTI12 AAA PF00004.29 EMD67705.1 - 0.00032 21.1 0.1 0.00093 19.6 0.0 1.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) NTPase_1 PF03266.15 EMD67705.1 - 0.001 19.0 0.4 0.0019 18.1 0.1 1.6 2 0 0 2 2 2 1 NTPase AAA_16 PF13191.6 EMD67705.1 - 0.0014 19.1 0.2 0.0034 17.8 0.2 1.9 1 1 0 1 1 1 1 AAA ATPase domain Hydin_ADK PF17213.3 EMD67705.1 - 0.0016 18.8 0.0 0.0027 18.0 0.0 1.3 1 0 0 1 1 1 1 Hydin Adenylate kinase-like domain Thymidylate_kin PF02223.17 EMD67705.1 - 0.0029 17.3 0.1 1.2 8.7 0.0 2.1 2 0 0 2 2 2 2 Thymidylate kinase SKI PF01202.22 EMD67705.1 - 0.0036 17.4 0.2 0.14 12.3 0.2 2.1 1 1 0 1 1 1 1 Shikimate kinase AAA_24 PF13479.6 EMD67705.1 - 0.0057 16.4 0.0 0.011 15.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EMD67705.1 - 0.0059 16.9 0.1 0.015 15.6 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 EMD67705.1 - 0.0078 16.2 0.0 0.015 15.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 EMD67705.1 - 0.019 14.7 0.1 0.03 14.1 0.1 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein RNA_helicase PF00910.22 EMD67705.1 - 0.028 14.8 0.0 0.046 14.1 0.0 1.4 1 0 0 1 1 1 0 RNA helicase NACHT PF05729.12 EMD67705.1 - 0.028 14.3 0.1 0.059 13.3 0.1 1.5 1 0 0 1 1 1 0 NACHT domain AAA_14 PF13173.6 EMD67705.1 - 0.034 14.2 0.0 0.065 13.3 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_3 PF07726.11 EMD67705.1 - 0.065 13.1 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Cytidylate_kin2 PF13189.6 EMD67705.1 - 0.072 13.2 0.0 0.4 10.8 0.0 1.9 2 0 0 2 2 2 0 Cytidylate kinase-like family Viral_helicase1 PF01443.18 EMD67705.1 - 0.089 12.5 0.0 0.12 12.1 0.0 1.2 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase MeaB PF03308.16 EMD67705.1 - 0.091 11.7 0.1 0.14 11.1 0.1 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB SRP54 PF00448.22 EMD67705.1 - 0.12 12.0 0.0 0.19 11.3 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_19 PF13245.6 EMD67705.1 - 0.12 12.7 0.3 0.25 11.6 0.3 1.5 1 0 0 1 1 1 0 AAA domain RuvB_N PF05496.12 EMD67705.1 - 0.15 11.8 0.3 0.26 11.0 0.0 1.5 2 0 0 2 2 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_30 PF13604.6 EMD67705.1 - 0.42 10.3 2.0 1 9.0 1.0 1.9 1 1 1 2 2 2 0 AAA domain NAP PF00956.18 EMD67706.1 - 1.5e-99 332.6 11.5 1.5e-99 332.6 11.5 1.7 2 0 0 2 2 2 1 Nucleosome assembly protein (NAP) MFS_2 PF13347.6 EMD67707.1 - 3e-12 45.8 4.7 3e-12 45.8 4.7 2.3 2 1 1 3 3 3 1 MFS/sugar transport protein MFS_1_like PF12832.7 EMD67707.1 - 0.00015 20.8 0.1 0.00015 20.8 0.1 2.4 1 1 0 2 2 2 1 MFS_1 like family BT1 PF03092.16 EMD67707.1 - 0.0033 15.7 4.8 0.0037 15.6 3.2 1.8 2 0 0 2 2 2 1 BT1 family Myosin_head PF00063.21 EMD67708.1 - 4.8e-263 874.4 0.5 4.8e-263 874.4 0.5 1.7 2 0 0 2 2 1 1 Myosin head (motor domain) DIL PF01843.19 EMD67708.1 - 5.1e-27 94.2 2.9 2.9e-26 91.8 2.9 2.4 1 0 0 1 1 1 1 DIL domain IQ PF00612.27 EMD67708.1 - 1.6e-12 46.0 26.0 0.00025 20.6 0.4 6.8 6 0 0 6 6 6 3 IQ calmodulin-binding motif Myosin_N PF02736.19 EMD67708.1 - 9.5e-05 22.2 2.3 0.00025 20.8 2.3 1.7 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain GAS PF13851.6 EMD67708.1 - 0.001 18.5 18.9 0.001 18.5 18.9 2.7 1 1 1 2 2 2 2 Growth-arrest specific micro-tubule binding AAA_22 PF13401.6 EMD67708.1 - 0.0052 17.1 2.3 0.0086 16.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EMD67708.1 - 0.0059 17.0 0.0 0.031 14.6 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain DUF812 PF05667.11 EMD67708.1 - 0.01 14.8 26.8 0.02 13.8 26.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF812) T2SSE PF00437.20 EMD67708.1 - 0.022 13.8 0.6 0.056 12.5 0.0 2.0 2 0 0 2 2 2 0 Type II/IV secretion system protein KASH_CCD PF14662.6 EMD67708.1 - 0.045 13.6 36.0 0.92 9.3 24.8 3.0 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH Flp_N PF03930.14 EMD67708.1 - 0.069 13.1 2.1 0.15 12.1 0.5 2.4 2 0 0 2 2 1 0 Recombinase Flp protein N-terminus FPP PF05911.11 EMD67708.1 - 0.069 11.3 26.3 0.13 10.4 26.3 1.4 1 0 0 1 1 1 0 Filament-like plant protein, long coiled-coil TsaE PF02367.17 EMD67708.1 - 0.097 12.7 0.0 0.34 10.9 0.0 1.9 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Atg14 PF10186.9 EMD67708.1 - 0.42 9.6 21.8 0.95 8.5 21.8 1.6 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 zf-C4H2 PF10146.9 EMD67708.1 - 0.54 10.5 14.7 0.17 12.2 10.8 2.3 2 0 0 2 2 1 0 Zinc finger-containing protein Phage_GP20 PF06810.11 EMD67708.1 - 0.59 9.9 21.7 0.18 11.6 9.2 3.2 1 1 1 2 2 2 0 Phage minor structural protein GP20 DUF1616 PF07760.11 EMD67708.1 - 5.6 6.3 6.8 7.1 5.9 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1616) DUF1664 PF07889.12 EMD67708.1 - 6.3 6.9 15.9 1.1 9.4 1.2 3.1 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) ING PF12998.7 EMD67708.1 - 8.3 7.1 17.3 1.3 9.6 6.3 3.4 1 1 1 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding 2-Hacid_dh_C PF02826.19 EMD67709.1 - 1.2e-53 181.1 0.0 2.1e-53 180.3 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EMD67709.1 - 1.4e-35 121.9 0.1 1.8e-35 121.5 0.1 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 EMD67709.1 - 0.0001 22.5 0.2 0.00028 21.1 0.2 1.7 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase AdoHcyase_NAD PF00670.21 EMD67709.1 - 0.0016 18.5 0.8 0.0027 17.8 0.1 1.7 2 0 0 2 2 2 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain IlvN PF07991.12 EMD67709.1 - 0.077 12.6 0.1 0.21 11.1 0.1 1.7 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain ACT PF01842.25 EMD67709.1 - 0.097 12.5 0.0 0.33 10.8 0.0 1.9 1 0 0 1 1 1 0 ACT domain G6PD_C PF02781.16 EMD67710.1 - 2.6e-115 384.6 0.0 4.4e-115 383.8 0.0 1.3 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.22 EMD67710.1 - 1.6e-60 204.8 0.0 2.9e-60 203.9 0.0 1.4 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, NAD binding domain Phosducin PF02114.16 EMD67712.1 - 5.9e-06 25.4 0.1 7.8e-06 25.0 0.1 1.2 1 0 0 1 1 1 1 Phosducin Thioredoxin PF00085.20 EMD67712.1 - 1.1e-05 25.3 0.0 2.2e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin EamA PF00892.20 EMD67713.1 - 1e-05 25.7 7.1 1e-05 25.7 7.1 2.1 2 0 0 2 2 2 2 EamA-like transporter family Zip PF02535.22 EMD67714.1 - 0.06 12.5 0.8 0.068 12.4 0.8 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Histone PF00125.24 EMD67715.1 - 1.2e-16 61.2 0.0 1.6e-16 60.9 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Histone_H2A_C PF16211.5 EMD67715.1 - 9e-13 47.7 0.1 2.2e-12 46.5 0.1 1.7 1 0 0 1 1 1 1 C-terminus of histone H2A CBFD_NFYB_HMF PF00808.23 EMD67715.1 - 0.0015 18.8 0.0 0.0021 18.3 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Striatin PF08232.12 EMD67716.1 - 7.5e-44 150.1 1.4 7.5e-44 150.1 1.4 2.3 2 1 0 2 2 2 1 Striatin family WD40 PF00400.32 EMD67716.1 - 6.8e-23 80.5 21.7 0.0016 19.2 0.2 8.6 8 1 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD67716.1 - 0.00031 21.0 0.0 2.4 8.5 0.0 4.3 3 1 0 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain KLRAQ PF10205.9 EMD67716.1 - 0.045 14.0 0.7 0.091 13.0 0.7 1.4 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein CASP_C PF08172.12 EMD67716.1 - 0.53 9.6 2.7 1.3 8.3 2.7 1.6 1 0 0 1 1 1 0 CASP C terminal ARD PF03079.14 EMD67717.1 - 6.2e-48 162.9 0.2 7.7e-48 162.6 0.2 1.1 1 0 0 1 1 1 1 ARD/ARD' family Cupin_2 PF07883.11 EMD67717.1 - 4.1e-10 39.2 0.0 6.6e-10 38.6 0.0 1.3 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.19 EMD67717.1 - 1.9e-06 27.8 0.0 2.5e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_1 PF00190.22 EMD67717.1 - 0.001 18.7 0.0 0.0016 18.1 0.0 1.2 1 0 0 1 1 1 1 Cupin Cupin_6 PF12852.7 EMD67717.1 - 0.071 12.8 0.0 0.09 12.5 0.0 1.1 1 0 0 1 1 1 0 Cupin DMSP_lyase PF16867.5 EMD67717.1 - 0.12 12.1 0.0 0.19 11.4 0.0 1.3 1 0 0 1 1 1 0 Dimethlysulfonioproprionate lyase DUF4078 PF13300.6 EMD67717.1 - 0.29 11.5 2.9 0.76 10.1 0.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4078) Bac_rhamnosid_C PF17390.2 EMD67718.1 - 4.4e-13 48.8 1.0 1e-12 47.6 1.0 1.7 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase C-terminal domain Laminin_G_3 PF13385.6 EMD67718.1 - 0.0074 16.5 0.1 0.023 14.8 0.1 1.9 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Bac_rhamnosid6H PF17389.2 EMD67718.1 - 0.024 13.9 0.0 0.053 12.8 0.0 1.5 1 0 0 1 1 1 0 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain MORN PF02493.20 EMD67719.1 - 9.2e-17 59.9 20.5 2.9e-05 23.7 0.8 4.7 4 0 0 4 4 4 4 MORN repeat zf-C3HC4_3 PF13920.6 EMD67719.1 - 1.5e-10 40.7 5.7 2.3e-10 40.1 5.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) USP7_ICP0_bdg PF12436.8 EMD67719.1 - 7.9e-08 31.9 0.0 1.8e-07 30.7 0.0 1.5 1 0 0 1 1 1 1 ICP0-binding domain of Ubiquitin-specific protease 7 UCH PF00443.29 EMD67719.1 - 1.1e-06 28.3 0.0 1.9e-06 27.6 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Prok-RING_4 PF14447.6 EMD67719.1 - 0.00053 19.8 5.8 0.00099 18.9 5.8 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 MATH PF00917.26 EMD67719.1 - 0.016 15.4 0.0 0.2 11.8 0.0 2.6 2 0 0 2 2 2 0 MATH domain zf-RING_2 PF13639.6 EMD67719.1 - 0.027 14.8 6.8 0.052 13.9 6.8 1.5 1 0 0 1 1 1 0 Ring finger domain zf-RING_5 PF14634.6 EMD67719.1 - 0.21 11.6 5.6 0.41 10.6 5.6 1.5 1 0 0 1 1 1 0 zinc-RING finger domain DS PF01916.17 EMD67720.1 - 8.2e-133 442.1 0.0 9.4e-133 441.9 0.0 1.0 1 0 0 1 1 1 1 Deoxyhypusine synthase Carbam_trans_N PF02543.15 EMD67720.1 - 0.16 11.6 0.0 0.23 11.1 0.0 1.2 1 0 0 1 1 1 0 Carbamoyltransferase N-terminus Myb_DNA-binding PF00249.31 EMD67721.1 - 1.9e-08 34.3 0.1 4.3e-05 23.6 0.0 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 EMD67721.1 - 0.0071 16.2 0.0 0.02 14.8 0.0 1.8 1 0 0 1 1 1 1 Myb DNA-binding like Myb_DNA-bind_6 PF13921.6 EMD67721.1 - 0.024 14.9 0.6 6.9 7.0 0.0 2.6 2 0 0 2 2 2 0 Myb-like DNA-binding domain Cation_efflux PF01545.21 EMD67722.1 - 3.1e-24 85.8 13.7 3.9e-24 85.5 13.7 1.1 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 EMD67722.1 - 2.6e-07 30.6 0.1 4.9e-07 29.8 0.1 1.4 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter Ribosomal_L39 PF00832.20 EMD67723.1 - 6.3e-22 76.9 9.4 7.3e-22 76.7 9.4 1.1 1 0 0 1 1 1 1 Ribosomal L39 protein CN_hydrolase PF00795.22 EMD67724.1 - 3.2e-14 52.9 0.0 1.2e-13 51.0 0.0 1.8 2 0 0 2 2 2 1 Carbon-nitrogen hydrolase ABC1 PF03109.16 EMD67725.1 - 1.4e-35 122.0 0.0 3.3e-35 120.8 0.0 1.7 1 0 0 1 1 1 1 ABC1 family Pkinase PF00069.25 EMD67725.1 - 0.2 11.0 0.0 14 5.0 0.0 2.3 2 0 0 2 2 2 0 Protein kinase domain ASFV_J13L PF05568.11 EMD67725.1 - 7.3 6.3 7.3 0.36 10.6 0.4 2.1 2 0 0 2 2 2 0 African swine fever virus J13L protein CDP-OH_P_transf PF01066.21 EMD67726.1 - 1.4e-14 54.6 0.5 1.4e-14 54.6 0.5 2.3 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase STE PF02200.16 EMD67728.1 - 3.1e-56 188.5 0.1 5e-56 187.8 0.1 1.3 1 0 0 1 1 1 1 STE like transcription factor zf-C2H2 PF00096.26 EMD67728.1 - 1.5e-11 44.1 10.0 1.7e-06 28.1 0.6 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMD67728.1 - 2.7e-09 37.0 2.5 2.7e-09 37.0 2.5 3.1 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMD67728.1 - 8.7e-08 32.4 8.1 0.00075 20.1 0.3 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EMD67728.1 - 6.8e-05 22.8 3.3 0.00031 20.7 0.1 2.5 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EMD67728.1 - 0.00088 19.5 0.1 0.024 14.9 0.0 2.4 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.12 EMD67728.1 - 0.008 16.5 2.8 0.014 15.7 2.8 1.4 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding CwsA PF10814.8 EMD67728.1 - 0.01 16.0 0.2 0.024 14.8 0.2 1.5 1 0 0 1 1 1 0 Cell wall synthesis protein CwsA zf-met PF12874.7 EMD67728.1 - 0.032 14.6 0.9 0.17 12.3 0.2 2.5 2 0 0 2 2 2 0 Zinc-finger of C2H2 type DUF2278 PF10042.9 EMD67728.1 - 0.049 13.6 0.0 0.83 9.6 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2278) FYDLN_acid PF09538.10 EMD67728.1 - 0.058 14.1 0.1 0.15 12.7 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) Zn-C2H2_12 PF18112.1 EMD67728.1 - 3.7 8.1 7.0 2.4 8.7 0.0 3.2 3 0 0 3 3 3 0 Autophagy receptor zinc finger-C2H2 domain zf-H2C2_5 PF13909.6 EMD67728.1 - 6.9 6.5 5.7 28 4.6 3.0 2.5 2 0 0 2 2 2 0 C2H2-type zinc-finger domain adh_short PF00106.25 EMD67729.1 - 1.1e-10 41.3 0.0 1.3e-10 41.0 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EMD67729.1 - 9.9e-08 32.1 0.0 1.5e-07 31.5 0.0 1.2 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.6 EMD67729.1 - 1.4e-07 31.3 0.0 1.7e-07 31.1 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Polysacc_synt_2 PF02719.15 EMD67729.1 - 0.041 13.0 0.0 0.054 12.6 0.0 1.1 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein TRM13 PF05206.14 EMD67729.1 - 0.2 11.1 0.0 0.3 10.6 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase TRM13 WD40 PF00400.32 EMD67730.1 - 1.2e-11 44.9 13.8 0.015 16.1 0.3 6.4 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD67730.1 - 0.00037 20.7 0.0 1.7 9.0 0.0 3.9 3 1 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain SSB PF00436.25 EMD67731.1 - 3.6e-13 49.4 0.0 4.5e-13 49.1 0.0 1.1 1 0 0 1 1 1 1 Single-strand binding protein family GIDA PF01134.22 EMD67732.1 - 2.9e-155 517.2 0.0 3.6e-155 516.9 0.0 1.1 1 0 0 1 1 1 1 Glucose inhibited division protein A GIDA_assoc PF13932.6 EMD67732.1 - 1e-64 218.6 0.0 1.6e-64 218.0 0.0 1.3 1 0 0 1 1 1 1 GidA associated domain FAD_oxidored PF12831.7 EMD67732.1 - 8.8e-08 31.9 0.8 1.5e-07 31.1 0.8 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EMD67732.1 - 4e-06 26.3 0.5 8.4e-06 25.2 0.5 1.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EMD67732.1 - 5e-05 22.6 3.0 5e-05 22.6 3.0 1.7 2 0 0 2 2 2 1 FAD binding domain AlaDh_PNT_C PF01262.21 EMD67732.1 - 0.0043 16.4 0.1 0.0077 15.5 0.1 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain HI0933_like PF03486.14 EMD67732.1 - 0.0049 15.6 1.0 0.073 11.8 0.8 2.1 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox PF00070.27 EMD67732.1 - 0.021 15.3 0.6 0.065 13.8 0.6 1.8 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EMD67732.1 - 0.028 14.0 2.4 3.5 7.1 0.0 2.4 2 0 0 2 2 2 0 FAD dependent oxidoreductase SMI1_KNR4 PF09346.10 EMD67733.1 - 7.3e-33 113.8 0.0 2.6e-32 112.0 0.0 1.9 1 1 0 1 1 1 1 SMI1 / KNR4 family (SUKH-1) ATP-synt_D PF01813.17 EMD67734.1 - 0.0023 17.8 1.9 0.0044 16.9 1.9 1.4 1 0 0 1 1 1 1 ATP synthase subunit D Ima1_N PF09779.9 EMD67734.1 - 0.016 16.0 1.8 0.041 14.7 1.8 1.6 1 0 0 1 1 1 0 Ima1 N-terminal domain SLY PF12485.8 EMD67734.1 - 0.051 14.3 0.3 0.11 13.2 0.3 1.5 1 0 0 1 1 1 0 Lymphocyte signaling adaptor protein ArdA PF07275.11 EMD67734.1 - 0.13 12.9 1.0 0.58 10.7 0.3 2.3 2 0 0 2 2 2 0 Antirestriction protein (ArdA) DUF1697 PF08002.11 EMD67734.1 - 0.18 12.3 0.6 0.44 11.0 0.6 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1697) Fib_alpha PF08702.10 EMD67734.1 - 0.2 11.9 2.7 2.1 8.5 0.1 2.7 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Macro PF01661.21 EMD67735.1 - 5.4e-38 129.7 0.0 1.5e-20 73.4 0.0 2.8 2 0 0 2 2 2 2 Macro domain RPA_C PF08784.11 EMD67735.1 - 0.0014 19.3 0.8 0.0038 17.8 0.1 2.2 2 0 0 2 2 2 1 Replication protein A C terminal zf-C2H2_4 PF13894.6 EMD67735.1 - 1.7 9.7 10.9 36 5.6 0.0 4.9 4 0 0 4 4 4 0 C2H2-type zinc finger F-box-like PF12937.7 EMD67736.1 - 0.012 15.5 0.8 0.094 12.6 0.1 2.3 2 0 0 2 2 2 0 F-box-like F-box PF00646.33 EMD67736.1 - 0.028 14.3 0.3 0.13 12.1 0.1 2.1 2 0 0 2 2 2 0 F-box domain Brix PF04427.18 EMD67738.1 - 9.5e-39 133.5 0.0 1.2e-38 133.1 0.0 1.1 1 0 0 1 1 1 1 Brix domain SNF2_N PF00176.23 EMD67739.1 - 5.3e-64 216.1 1.3 1.5e-63 214.6 1.3 1.8 1 0 0 1 1 1 1 SNF2 family N-terminal domain DBINO PF13892.6 EMD67739.1 - 5.3e-47 159.5 21.5 5.3e-47 159.5 21.5 4.3 3 1 0 3 3 3 1 DNA-binding domain Helicase_C PF00271.31 EMD67739.1 - 1.5e-19 70.4 0.1 5.4e-19 68.6 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain TPT PF03151.16 EMD67739.1 - 6.8e-08 32.2 15.8 1.1e-07 31.5 15.8 1.3 1 0 0 1 1 1 1 Triose-phosphate Transporter family ResIII PF04851.15 EMD67739.1 - 1.1e-06 28.8 0.4 3.8e-06 27.0 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit EamA PF00892.20 EMD67739.1 - 0.00061 20.0 9.5 0.00061 20.0 9.5 2.3 2 0 0 2 2 2 1 EamA-like transporter family HDA2-3 PF11496.8 EMD67739.1 - 0.0044 16.2 0.0 0.0044 16.2 0.0 3.0 4 0 0 4 4 4 1 Class II histone deacetylase complex subunits 2 and 3 DEAD PF00270.29 EMD67739.1 - 0.0061 16.3 0.0 0.017 14.9 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase DNA_RNApol_7kD PF03604.13 EMD67742.1 - 0.011 15.4 0.1 0.46 10.2 0.0 2.4 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit Zf_RING PF16744.5 EMD67742.1 - 0.039 14.1 0.3 0.084 13.0 0.3 1.5 1 0 0 1 1 1 0 KIAA1045 RING finger Desulfoferrod_N PF06397.12 EMD67742.1 - 0.073 12.7 0.8 1.4 8.6 0.1 2.3 2 0 0 2 2 2 0 Desulfoferrodoxin, N-terminal domain PyrI_C PF02748.15 EMD67742.1 - 0.16 11.9 0.7 20 5.2 0.1 2.4 2 0 0 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-CHCC PF10276.9 EMD67742.1 - 0.38 10.8 1.9 21 5.3 0.2 2.4 2 0 0 2 2 2 0 Zinc-finger domain DUF2616 PF11077.8 EMD67742.1 - 2.7 7.7 4.8 3.6 7.3 0.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2616) Phosphodiest PF01663.22 EMD67743.1 - 8.9e-14 51.8 1.8 6.9e-08 32.5 0.1 2.4 2 1 0 3 3 3 2 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 EMD67743.1 - 0.00011 21.7 0.0 0.00062 19.3 0.0 2.0 2 0 0 2 2 2 1 Sulfatase DUF229 PF02995.17 EMD67743.1 - 0.16 10.6 0.0 0.23 10.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF229) PigN PF04987.14 EMD67743.1 - 0.42 9.4 17.7 0.032 13.1 6.1 2.6 2 0 0 2 2 2 0 Phosphatidylinositolglycan class N (PIG-N) FUN14 PF04930.15 EMD67744.1 - 2.5e-07 31.0 1.5 4.4e-07 30.2 1.5 1.4 1 0 0 1 1 1 1 FUN14 family Importin_rep PF18773.1 EMD67745.1 - 7.8e-05 22.3 0.2 0.00017 21.2 0.2 1.6 1 0 0 1 1 1 1 Importin 13 repeat RIX1 PF08167.12 EMD67745.1 - 0.00066 19.5 4.5 0.18 11.5 0.4 3.7 4 0 0 4 4 4 2 rRNA processing/ribosome biogenesis IBN_N PF03810.19 EMD67745.1 - 0.0021 17.9 0.2 0.021 14.7 0.1 2.9 2 0 0 2 2 2 1 Importin-beta N-terminal domain UME PF08064.13 EMD67745.1 - 0.0072 16.2 0.2 9.8 6.2 0.0 4.0 3 0 0 3 3 3 1 UME (NUC010) domain Sec7_N PF12783.7 EMD67745.1 - 0.02 14.8 3.1 4.4 7.2 0.1 3.9 3 0 0 3 3 3 0 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF760 PF05542.11 EMD67745.1 - 0.06 13.7 0.1 1 9.8 0.1 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF760) EST1 PF10374.9 EMD67745.1 - 0.084 13.5 0.0 0.41 11.3 0.0 2.2 1 0 0 1 1 1 0 Telomerase activating protein Est1 Xpo1 PF08389.12 EMD67745.1 - 0.18 11.9 5.1 33 4.5 0.0 5.3 5 2 1 6 6 6 0 Exportin 1-like protein Vps35 PF03635.17 EMD67745.1 - 0.85 8.0 4.8 12 4.2 0.1 3.0 3 1 0 3 3 3 0 Vacuolar protein sorting-associated protein 35 Creatinase_N_2 PF16189.5 EMD67746.1 - 2.4e-56 190.3 1.3 2.3e-54 183.9 0.0 3.2 4 0 0 4 4 4 1 Creatinase/Prolidase N-terminal domain Peptidase_M24 PF00557.24 EMD67746.1 - 2e-44 151.8 0.0 3.7e-44 150.9 0.0 1.5 1 0 0 1 1 1 1 Metallopeptidase family M24 Creatinase_N PF01321.18 EMD67746.1 - 2.1e-21 76.9 0.0 6.3e-19 68.9 0.0 2.6 2 0 0 2 2 2 2 Creatinase/Prolidase N-terminal domain Peptidase_M24_C PF16188.5 EMD67746.1 - 2.5e-21 75.5 0.3 6.1e-21 74.3 0.3 1.7 1 0 0 1 1 1 1 C-terminal region of peptidase_M24 DUF5420 PF17457.2 EMD67746.1 - 0.062 13.2 0.0 0.24 11.3 0.0 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5420) SOR_SNZ PF01680.17 EMD67747.1 - 2.3e-110 367.3 6.9 3.5e-110 366.7 6.9 1.3 1 0 0 1 1 1 1 SOR/SNZ family ThiG PF05690.14 EMD67747.1 - 1.9e-09 37.2 6.2 2e-06 27.3 0.2 2.5 2 1 0 2 2 2 2 Thiazole biosynthesis protein ThiG His_biosynth PF00977.21 EMD67747.1 - 0.00067 19.2 0.1 0.059 12.8 0.0 2.4 2 1 1 3 3 3 2 Histidine biosynthesis protein NanE PF04131.14 EMD67747.1 - 0.00067 18.9 0.9 0.015 14.5 0.0 2.5 2 1 0 2 2 2 1 Putative N-acetylmannosamine-6-phosphate epimerase IGPS PF00218.21 EMD67747.1 - 0.00094 18.4 0.1 0.12 11.5 0.0 2.5 2 0 0 2 2 2 2 Indole-3-glycerol phosphate synthase Dus PF01207.17 EMD67747.1 - 0.0014 17.8 1.3 0.24 10.5 0.1 2.4 2 1 0 2 2 2 2 Dihydrouridine synthase (Dus) TetR_C_27 PF17935.1 EMD67747.1 - 0.0065 16.5 0.0 0.017 15.1 0.0 1.6 1 0 0 1 1 1 1 Tetracyclin repressor-like, C-terminal domain FMN_dh PF01070.18 EMD67747.1 - 0.012 14.6 0.4 0.13 11.3 0.0 2.1 2 0 0 2 2 2 0 FMN-dependent dehydrogenase TMP-TENI PF02581.17 EMD67747.1 - 0.04 13.3 0.9 1 8.6 0.1 2.9 2 1 1 3 3 3 0 Thiamine monophosphate synthase NMO PF03060.15 EMD67747.1 - 0.1 12.0 6.4 0.19 11.1 0.2 2.3 2 0 0 2 2 2 0 Nitronate monooxygenase Skp1 PF01466.19 EMD67748.1 - 9.4e-29 99.3 0.5 1.5e-28 98.6 0.5 1.4 1 0 0 1 1 1 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.15 EMD67748.1 - 1.2e-20 73.5 0.2 3e-20 72.1 0.1 1.8 2 0 0 2 2 2 1 Skp1 family, tetramerisation domain Glyco_transf_22 PF03901.17 EMD67749.1 - 6.8e-58 196.9 22.4 8.9e-58 196.5 22.4 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family PLDc_2 PF13091.6 EMD67750.1 - 3.4e-15 56.1 0.0 3.8e-08 33.3 0.0 2.4 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.22 EMD67750.1 - 3.4e-06 27.0 5.2 0.33 11.2 0.0 3.7 4 0 0 4 4 4 3 Phospholipase D Active site motif Virulence_RhuM PF13310.6 EMD67750.1 - 0.11 11.7 0.0 0.2 10.8 0.0 1.3 1 0 0 1 1 1 0 Virulence protein RhuM family NDUFA12 PF05071.16 EMD67751.1 - 1e-28 100.0 3.5 1.2e-28 99.7 3.5 1.1 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase subunit NDUFA12 NAD_binding_8 PF13450.6 EMD67752.1 - 5.8e-10 39.3 0.1 1.3e-09 38.1 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 EMD67752.1 - 4.4e-08 32.8 0.0 9.6e-08 31.7 0.0 1.5 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase FAD_oxidored PF12831.7 EMD67752.1 - 2.6e-06 27.1 1.6 5.1e-06 26.1 1.4 1.5 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 EMD67752.1 - 8.4e-06 26.3 0.2 3.1e-05 24.4 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EMD67752.1 - 1.2e-05 24.7 0.0 2.4e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EMD67752.1 - 2.4e-05 23.6 0.7 3.7e-05 23.0 0.7 1.2 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 EMD67752.1 - 4.1e-05 23.3 0.6 0.00038 20.1 0.9 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.17 EMD67752.1 - 0.00011 21.5 0.2 0.0002 20.7 0.2 1.3 1 0 0 1 1 1 1 Thi4 family HI0933_like PF03486.14 EMD67752.1 - 0.00017 20.5 0.5 0.00038 19.3 0.5 1.6 1 0 0 1 1 1 1 HI0933-like protein FAD_binding_3 PF01494.19 EMD67752.1 - 0.00021 20.6 0.2 0.00035 19.9 0.2 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.6 EMD67752.1 - 0.0025 17.1 0.0 0.0043 16.3 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EMD67752.1 - 0.0048 16.0 0.5 0.0076 15.4 0.5 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A Trp_halogenase PF04820.14 EMD67752.1 - 0.01 14.7 0.8 0.016 14.1 0.8 1.3 1 0 0 1 1 1 0 Tryptophan halogenase IlvN PF07991.12 EMD67752.1 - 0.018 14.6 0.2 0.034 13.7 0.2 1.4 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain AlaDh_PNT_C PF01262.21 EMD67752.1 - 0.14 11.5 0.4 0.28 10.4 0.4 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain NAD_Gly3P_dh_N PF01210.23 EMD67752.1 - 0.15 12.1 0.1 0.25 11.3 0.1 1.4 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus ABC_tran PF00005.27 EMD67753.1 - 2.1e-54 183.7 0.1 2.3e-30 105.9 0.0 3.3 2 1 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EMD67753.1 - 2.7e-49 168.3 25.2 4.8e-34 118.3 4.7 3.4 3 0 0 3 3 3 2 ABC transporter transmembrane region SMC_N PF02463.19 EMD67753.1 - 3.5e-09 36.4 0.4 0.092 12.2 0.0 4.3 4 0 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EMD67753.1 - 8e-06 25.9 0.0 0.051 13.4 0.0 3.4 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 EMD67753.1 - 1.9e-05 24.6 0.0 0.015 15.2 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_23 PF13476.6 EMD67753.1 - 6.8e-05 23.5 3.1 0.0064 17.0 0.0 3.2 3 0 0 3 3 3 1 AAA domain AAA_16 PF13191.6 EMD67753.1 - 0.00083 19.8 0.0 2.3 8.6 0.0 2.8 2 0 0 2 2 2 2 AAA ATPase domain MMR_HSR1 PF01926.23 EMD67753.1 - 0.0012 18.9 0.4 0.23 11.5 0.0 2.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_22 PF13401.6 EMD67753.1 - 0.0013 19.0 1.0 6.7 7.0 0.2 3.4 3 0 0 3 3 3 0 AAA domain AAA_29 PF13555.6 EMD67753.1 - 0.0016 18.1 0.3 2.2 8.1 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_25 PF13481.6 EMD67753.1 - 0.0054 16.3 0.3 0.6 9.6 0.0 2.6 2 0 0 2 2 2 1 AAA domain T2SSE PF00437.20 EMD67753.1 - 0.0056 15.8 0.0 0.16 11.0 0.0 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_7 PF12775.7 EMD67753.1 - 0.0066 16.0 0.3 3.7 7.0 0.1 2.5 2 0 0 2 2 2 2 P-loop containing dynein motor region DUF87 PF01935.17 EMD67753.1 - 0.0081 16.3 5.2 0.076 13.1 0.0 3.4 3 0 0 3 3 3 1 Helicase HerA, central domain AAA_30 PF13604.6 EMD67753.1 - 0.021 14.6 3.1 2.1 8.0 0.0 3.2 3 0 0 3 3 3 0 AAA domain TrwB_AAD_bind PF10412.9 EMD67753.1 - 0.038 12.9 1.9 0.52 9.2 0.0 2.3 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain IstB_IS21 PF01695.17 EMD67753.1 - 0.049 13.4 0.0 4.6 6.9 0.0 2.8 2 0 0 2 2 2 0 IstB-like ATP binding protein Zeta_toxin PF06414.12 EMD67753.1 - 0.052 12.8 1.4 8.6 5.6 0.0 3.0 3 0 0 3 3 3 0 Zeta toxin DEAD PF00270.29 EMD67753.1 - 0.053 13.3 0.1 33 4.2 0.0 3.4 3 0 0 3 3 3 0 DEAD/DEAH box helicase AAA_33 PF13671.6 EMD67753.1 - 0.063 13.4 0.1 2.7 8.1 0.1 2.7 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 EMD67753.1 - 0.067 13.6 0.1 31 5.0 0.0 3.1 3 0 0 3 3 3 0 RNA helicase CbiA PF01656.23 EMD67753.1 - 0.086 12.9 0.7 0.65 10.1 0.0 2.5 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA PF00004.29 EMD67753.1 - 0.12 12.8 1.0 34 4.9 0.1 3.4 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EMD67753.1 - 0.14 12.2 0.5 7.3 6.6 0.0 2.9 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) cobW PF02492.19 EMD67753.1 - 0.32 10.6 2.7 1 8.9 0.5 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.12 EMD67753.1 - 1.4 8.8 3.0 3.8 7.4 0.4 2.4 2 0 0 2 2 2 0 NACHT domain Dynamin_N PF00350.23 EMD67753.1 - 2.2 8.3 6.0 15 5.6 0.1 3.0 3 0 0 3 3 3 0 Dynamin family XPA_C PF05181.12 EMD67754.1 - 9.4e-24 83.1 1.1 1.8e-23 82.2 1.1 1.5 1 0 0 1 1 1 1 XPA protein C-terminus XPA_N PF01286.18 EMD67754.1 - 5.4e-05 23.1 1.8 5.4e-05 23.1 1.8 2.3 2 0 0 2 2 2 1 XPA protein N-terminal zf-AD PF07776.15 EMD67754.1 - 0.049 13.9 0.2 0.26 11.6 0.1 2.2 2 0 0 2 2 2 0 Zinc-finger associated domain (zf-AD) ADD_DNMT3 PF17980.1 EMD67754.1 - 0.099 12.7 0.1 0.23 11.5 0.1 1.6 1 0 0 1 1 1 0 Cysteine rich ADD domain in DNMT3 TF_Zn_Ribbon PF08271.12 EMD67754.1 - 6.3 6.4 6.4 1.2 8.7 0.2 2.6 3 0 0 3 3 3 0 TFIIB zinc-binding Pept_tRNA_hydro PF01195.19 EMD67755.1 - 6.3e-30 104.4 0.0 9e-30 103.9 0.0 1.2 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase Methyltrans_RNA PF04452.14 EMD67755.1 - 0.004 16.5 0.6 0.0062 15.9 0.6 1.2 1 0 0 1 1 1 1 RNA methyltransferase Cut12 PF11500.8 EMD67756.1 - 3e-26 92.1 13.7 3e-26 92.1 13.7 3.4 3 2 0 3 3 3 1 Spindle pole body formation-associated protein FapA PF03961.13 EMD67756.1 - 3.5 6.1 7.9 6.2 5.3 7.9 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A HGTP_anticodon2 PF12745.7 EMD67757.1 - 1.9e-78 263.6 0.1 1.9e-78 263.6 0.1 2.1 2 0 0 2 2 2 1 Anticodon binding domain of tRNAs Pkinase PF00069.25 EMD67757.1 - 7.5e-74 248.4 0.0 1.8e-34 119.3 0.0 3.7 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 EMD67757.1 - 4.2e-43 147.5 0.0 5.9e-17 61.8 0.0 4.0 4 1 0 4 4 4 3 Protein tyrosine kinase RWD PF05773.22 EMD67757.1 - 3.1e-13 50.0 0.1 2.3e-12 47.2 0.1 2.5 2 0 0 2 2 2 1 RWD domain tRNA-synt_His PF13393.6 EMD67757.1 - 5e-11 42.4 0.0 3.2e-10 39.8 0.0 2.2 1 1 1 2 2 2 1 Histidyl-tRNA synthetase Kinase-like PF14531.6 EMD67757.1 - 2e-06 27.3 0.0 4.9e-05 22.8 0.0 2.3 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 EMD67757.1 - 0.0017 18.4 2.2 0.12 12.3 0.0 3.2 3 0 0 3 3 3 1 Phosphotransferase enzyme family Kdo PF06293.14 EMD67757.1 - 0.0031 16.9 0.0 0.54 9.6 0.0 2.5 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Hydant_A_N PF05378.13 EMD67757.1 - 0.053 13.2 0.0 0.67 9.6 0.0 2.3 2 0 0 2 2 2 0 Hydantoinase/oxoprolinase N-terminal region Spheroidin PF05541.12 EMD67759.1 - 0.079 10.8 0.0 0.094 10.5 0.0 1.1 1 0 0 1 1 1 0 Entomopoxvirus spheroidin protein Arc PF03869.14 EMD67760.1 - 0.012 15.4 0.1 0.021 14.6 0.1 1.4 1 0 0 1 1 1 0 Arc-like DNA binding domain LIN37 PF15306.6 EMD67760.1 - 0.057 13.6 0.7 0.069 13.4 0.7 1.1 1 0 0 1 1 1 0 LIN37 Ytp1 PF10355.9 EMD67761.1 - 8.7e-72 241.6 20.3 8.7e-72 241.6 20.3 2.4 2 1 0 2 2 2 1 Protein of unknown function (Ytp1) DUF2427 PF10348.9 EMD67761.1 - 9.9e-32 108.9 1.0 9.9e-32 108.9 1.0 3.5 4 1 0 4 4 4 1 Domain of unknown function (DUF2427) Swi5 PF07061.11 EMD67762.1 - 3.8e-26 91.0 0.5 4e-26 90.9 0.5 1.0 1 0 0 1 1 1 1 Swi5 Arm_vescicular PF18770.1 EMD67765.1 - 0.0051 16.7 0.0 0.022 14.7 0.0 2.0 2 0 0 2 2 2 1 Armadillo tether-repeat of vescicular transport factor PAZ PF02170.22 EMD67766.1 - 0.021 14.6 0.0 0.035 13.9 0.0 1.3 1 0 0 1 1 1 0 PAZ domain DUF5326 PF17260.2 EMD67766.1 - 0.041 14.0 0.1 0.076 13.2 0.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5326) SAC3_GANP PF03399.16 EMD67767.1 - 7.3e-81 271.8 2.2 7.3e-81 271.8 2.2 2.2 2 1 0 2 2 2 1 SAC3/GANP family CSN8_PSD8_EIF3K PF10075.9 EMD67767.1 - 3.9e-05 23.7 0.0 0.00049 20.1 0.0 2.4 1 1 0 1 1 1 1 CSN8/PSMD8/EIF3K family ETC_C1_NDUFA4 PF04800.12 EMD67767.1 - 0.013 15.7 0.0 0.047 13.9 0.0 2.0 1 0 0 1 1 1 0 ETC complex I subunit conserved region DUF2841 PF11001.8 EMD67768.1 - 3e-18 66.0 0.3 4.8e-18 65.4 0.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2841) ABC_membrane PF00664.23 EMD67769.1 - 3.8e-84 282.6 24.8 3.6e-46 158.0 6.7 2.4 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EMD67769.1 - 8.9e-53 178.5 0.0 4e-30 105.1 0.0 2.6 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EMD67769.1 - 8.4e-10 38.4 1.4 0.039 13.4 0.1 4.3 3 1 0 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 EMD67769.1 - 1e-06 29.2 0.9 0.011 16.1 0.1 2.9 2 1 0 2 2 2 2 AAA ATPase domain MMR_HSR1 PF01926.23 EMD67769.1 - 1.9e-06 28.0 0.7 0.059 13.5 0.0 2.9 3 0 0 3 3 3 2 50S ribosome-binding GTPase AAA_29 PF13555.6 EMD67769.1 - 1.1e-05 25.1 0.1 0.052 13.3 0.0 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_23 PF13476.6 EMD67769.1 - 3.1e-05 24.6 0.5 0.0034 17.9 0.0 2.9 3 0 0 3 3 3 1 AAA domain RsgA_GTPase PF03193.16 EMD67769.1 - 3.9e-05 23.6 0.1 0.0093 15.9 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_21 PF13304.6 EMD67769.1 - 0.00011 22.1 0.2 0.041 13.7 0.0 2.7 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system Dynamin_N PF00350.23 EMD67769.1 - 0.0046 17.0 0.8 0.48 10.5 0.0 2.5 2 0 0 2 2 2 1 Dynamin family DUP PF00674.18 EMD67769.1 - 0.0089 16.1 0.4 0.035 14.2 0.4 2.0 1 0 0 1 1 1 1 DUP family AAA_15 PF13175.6 EMD67769.1 - 0.014 15.1 2.0 0.24 11.1 0.0 2.5 3 0 0 3 3 2 0 AAA ATPase domain DUF1689 PF07954.11 EMD67769.1 - 0.02 15.3 0.9 2.4 8.6 0.2 2.7 1 1 0 2 2 2 0 Protein of unknown function (DUF1689) AAA_30 PF13604.6 EMD67769.1 - 0.031 14.0 1.2 0.51 10.0 0.0 2.9 2 1 0 2 2 2 0 AAA domain Roc PF08477.13 EMD67769.1 - 0.034 14.4 1.1 36 4.6 0.0 3.6 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase IstB_IS21 PF01695.17 EMD67769.1 - 0.035 13.8 0.1 9.4 5.9 0.0 2.7 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_27 PF13514.6 EMD67769.1 - 0.035 13.7 0.1 0.14 11.7 0.0 1.9 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 EMD67769.1 - 0.053 12.8 0.0 8.6 5.6 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin DUF87 PF01935.17 EMD67769.1 - 0.057 13.5 0.5 2.9 7.9 0.1 2.6 2 0 0 2 2 2 0 Helicase HerA, central domain CCB1 PF12046.8 EMD67769.1 - 0.079 12.3 4.2 0.16 11.3 0.0 3.4 4 0 0 4 4 4 0 Cofactor assembly of complex C subunit B 60KD_IMP PF02096.20 EMD67769.1 - 0.13 12.2 2.9 0.43 10.5 2.9 1.8 1 0 0 1 1 1 0 60Kd inner membrane protein AAA_22 PF13401.6 EMD67769.1 - 0.16 12.2 4.3 3.6 7.9 0.0 3.4 3 1 0 3 3 2 0 AAA domain NACHT PF05729.12 EMD67769.1 - 1.2 9.1 2.9 1.5 8.7 0.1 2.5 3 0 0 3 3 3 0 NACHT domain Glyco_transf_8 PF01501.20 EMD67770.1 - 0.0019 17.8 0.4 0.68 9.4 0.0 2.1 2 0 0 2 2 2 2 Glycosyl transferase family 8 Nucleotid_trans PF03407.16 EMD67770.1 - 0.046 13.7 0.2 0.074 13.0 0.2 1.3 1 1 0 1 1 1 0 Nucleotide-diphospho-sugar transferase Glyco_hydro_18 PF00704.28 EMD67772.1 - 1.2e-62 212.5 0.0 1.4e-62 212.2 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 DUF3574 PF12098.8 EMD67772.1 - 0.17 11.7 0.1 0.33 10.8 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3574) GH131_N PF18271.1 EMD67773.1 - 3.2e-62 210.5 3.0 3.8e-62 210.3 3.0 1.1 1 0 0 1 1 1 1 Glycoside hydrolase 131 catalytic N-terminal domain Polysacc_lyase PF14099.6 EMD67773.1 - 0.0043 16.9 2.6 0.015 15.2 2.4 1.8 1 1 0 1 1 1 1 Polysaccharide lyase HATPase_c PF02518.26 EMD67774.1 - 7.9e-24 84.3 0.0 1.8e-23 83.2 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EMD67774.1 - 7.4e-23 80.9 0.0 2e-22 79.5 0.0 1.8 1 0 0 1 1 1 1 Response regulator receiver domain PAS_4 PF08448.10 EMD67774.1 - 1.1e-10 41.7 0.0 9.4e-06 25.8 0.0 3.4 3 0 0 3 3 3 2 PAS fold HisKA PF00512.25 EMD67774.1 - 2.7e-09 36.9 0.0 7.3e-09 35.5 0.0 1.8 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain PAS_9 PF13426.7 EMD67774.1 - 7.9e-07 29.3 0.1 1.5e-05 25.2 0.0 3.1 3 0 0 3 3 3 1 PAS domain PAS PF00989.25 EMD67774.1 - 5e-06 26.5 0.0 1.8e-05 24.7 0.0 2.1 1 0 0 1 1 1 1 PAS fold PAS_8 PF13188.7 EMD67774.1 - 0.16 12.1 0.0 0.42 10.7 0.0 1.8 1 0 0 1 1 1 0 PAS domain Gti1_Pac2 PF09729.9 EMD67776.1 - 2e-55 187.7 0.1 2e-55 187.7 0.1 1.8 2 0 0 2 2 2 1 Gti1/Pac2 family RAI1 PF08652.11 EMD67781.1 - 7.5e-23 80.5 0.0 1.4e-22 79.7 0.0 1.4 1 0 0 1 1 1 1 RAI1 like PD-(D/E)XK nuclease RRM_2 PF04059.12 EMD67783.1 - 3e-30 104.3 0.1 5.1e-30 103.5 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif 2 RRM_1 PF00076.22 EMD67783.1 - 0.0029 17.4 0.7 0.1 12.4 0.0 3.3 4 0 0 4 4 4 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SH3_2 PF07653.17 EMD67783.1 - 0.088 12.5 0.0 0.16 11.6 0.0 1.4 1 0 0 1 1 1 0 Variant SH3 domain FLYWCH PF04500.16 EMD67784.1 - 0.085 13.0 1.4 0.16 12.1 1.4 1.5 1 1 0 1 1 1 0 FLYWCH zinc finger domain Sec15 PF04091.12 EMD67786.1 - 4e-104 348.4 3.6 4e-104 348.4 3.6 2.0 2 0 0 2 2 2 1 Exocyst complex subunit Sec15-like COG2 PF06148.11 EMD67786.1 - 4e-06 26.9 4.7 1.9e-05 24.7 4.7 2.2 1 0 0 1 1 1 1 COG (conserved oligomeric Golgi) complex component, COG2 Vps54_N PF10475.9 EMD67786.1 - 0.00068 19.0 5.4 0.0018 17.6 5.4 1.7 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex Sec8_exocyst PF04048.14 EMD67786.1 - 0.00083 19.3 3.7 0.00083 19.3 3.7 2.5 2 0 0 2 2 2 1 Sec8 exocyst complex component specific domain COG5 PF10392.9 EMD67786.1 - 0.03 14.5 4.3 0.032 14.4 1.3 2.7 3 0 0 3 3 3 0 Golgi transport complex subunit 5 ANAPC5 PF12862.7 EMD67786.1 - 0.034 14.2 0.5 0.14 12.3 0.5 2.2 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 5 Sec5 PF15469.6 EMD67786.1 - 0.58 9.9 11.7 0.031 14.1 3.6 2.7 3 1 0 3 3 3 0 Exocyst complex component Sec5 Vps51 PF08700.11 EMD67786.1 - 0.71 10.0 4.2 0.5 10.5 0.4 2.8 2 1 0 2 2 2 0 Vps51/Vps67 ApoLp-III PF07464.11 EMD67786.1 - 4.6 7.3 9.3 0.7 10.0 2.1 3.0 2 1 1 3 3 3 0 Apolipophorin-III precursor (apoLp-III) Sacchrp_dh_C PF16653.5 EMD67787.1 - 1.8e-94 316.8 0.0 2.4e-94 316.4 0.0 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase C-terminal domain Sacchrp_dh_NADP PF03435.18 EMD67787.1 - 7.6e-26 90.9 0.9 1.2e-25 90.3 0.9 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 EMD67787.1 - 3.5e-09 36.8 0.1 7.5e-09 35.8 0.1 1.6 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_10 PF13460.6 EMD67787.1 - 1.1e-05 25.4 1.1 1.7e-05 24.8 1.1 1.3 1 0 0 1 1 1 1 NAD(P)H-binding IlvN PF07991.12 EMD67787.1 - 0.0083 15.7 0.9 0.049 13.2 0.3 2.5 2 1 0 2 2 2 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain AlaDh_PNT_C PF01262.21 EMD67787.1 - 0.014 14.7 0.8 0.022 14.1 0.8 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_7 PF13241.6 EMD67787.1 - 0.024 15.1 0.2 0.051 14.0 0.2 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding NmrA PF05368.13 EMD67787.1 - 0.055 13.0 0.4 0.088 12.3 0.4 1.3 1 0 0 1 1 1 0 NmrA-like family adh_short PF00106.25 EMD67787.1 - 0.064 12.7 0.1 0.13 11.7 0.1 1.5 1 0 0 1 1 1 0 short chain dehydrogenase TrkA_N PF02254.18 EMD67787.1 - 0.067 13.5 0.8 0.13 12.5 0.8 1.5 1 0 0 1 1 1 0 TrkA-N domain GFO_IDH_MocA PF01408.22 EMD67787.1 - 0.075 13.9 0.1 0.15 12.9 0.1 1.6 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold DUF410 PF04190.13 EMD67788.1 - 2.9e-89 299.3 0.0 3.5e-89 299.0 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF410) DUF1933 PF09147.10 EMD67788.1 - 0.022 14.4 0.0 0.035 13.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1933) Sybindin PF04099.12 EMD67789.1 - 1.2e-25 90.1 0.0 1.4e-25 89.9 0.0 1.1 1 0 0 1 1 1 1 Sybindin-like family Sedlin_N PF04628.13 EMD67789.1 - 0.035 14.2 0.0 0.05 13.7 0.0 1.2 1 0 0 1 1 1 0 Sedlin, N-terminal conserved region Pkinase PF00069.25 EMD67790.1 - 8e-62 209.0 0.1 4e-55 187.0 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EMD67790.1 - 9e-39 133.3 0.3 6e-37 127.3 0.1 2.2 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 EMD67790.1 - 3.4e-08 33.1 0.0 1.6e-06 27.7 0.0 2.2 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 EMD67790.1 - 0.00014 20.7 0.2 0.00014 20.7 0.2 2.5 2 1 0 2 2 2 1 Fungal protein kinase APH PF01636.23 EMD67790.1 - 0.0037 17.2 1.6 0.0056 16.6 0.0 1.9 2 1 0 2 2 2 1 Phosphotransferase enzyme family FTA2 PF13095.6 EMD67790.1 - 0.12 12.0 0.0 1.2 8.7 0.0 2.3 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Helicase_C_2 PF13307.6 EMD67791.1 - 0.12 12.6 0.0 0.22 11.7 0.0 1.4 1 0 0 1 1 1 0 Helicase C-terminal domain Pkinase PF00069.25 EMD67794.1 - 3.6e-50 170.8 0.0 4.9e-50 170.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD67794.1 - 1.7e-29 102.9 0.0 2.6e-29 102.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EMD67794.1 - 0.0028 17.0 0.0 0.0048 16.3 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EMD67794.1 - 0.0086 15.4 0.0 0.022 14.1 0.0 1.7 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EMD67794.1 - 0.024 14.6 0.4 1 9.2 0.0 2.8 2 1 1 3 3 3 0 Phosphotransferase enzyme family Sad1_UNC PF07738.13 EMD67795.1 - 1.2e-31 109.4 0.0 2.2e-31 108.6 0.0 1.5 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal AAA PF00004.29 EMD67797.1 - 3e-41 141.0 0.0 5.3e-41 140.1 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EMD67797.1 - 2.3e-10 40.1 0.3 4.6e-10 39.1 0.3 1.5 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 EMD67797.1 - 1.3e-09 37.9 0.1 2.4e-09 37.0 0.1 1.5 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_2 PF07724.14 EMD67797.1 - 3.5e-06 27.2 0.0 7.2e-06 26.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 EMD67797.1 - 4.4e-06 27.0 0.2 0.018 15.3 0.1 2.6 1 1 1 2 2 2 2 AAA domain DUF815 PF05673.13 EMD67797.1 - 1.6e-05 24.2 0.0 2.7e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_5 PF07728.14 EMD67797.1 - 1.8e-05 24.7 0.0 5.5e-05 23.2 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EMD67797.1 - 0.00026 21.4 0.2 0.0017 18.7 0.2 2.1 1 1 0 1 1 1 1 AAA ATPase domain RuvB_N PF05496.12 EMD67797.1 - 0.00033 20.4 0.0 0.00068 19.4 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_28 PF13521.6 EMD67797.1 - 0.0031 17.8 0.0 0.0076 16.5 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EMD67797.1 - 0.0073 16.9 0.0 0.016 15.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.6 EMD67797.1 - 0.0088 16.1 0.0 0.019 15.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EMD67797.1 - 0.0089 16.2 0.0 0.025 14.8 0.0 1.8 2 0 0 2 2 1 1 AAA domain IstB_IS21 PF01695.17 EMD67797.1 - 0.016 15.0 0.0 0.04 13.7 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_3 PF07726.11 EMD67797.1 - 0.019 14.8 0.0 0.041 13.7 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) TIP49 PF06068.13 EMD67797.1 - 0.021 14.1 1.5 0.047 12.9 0.0 2.0 2 1 1 3 3 3 0 TIP49 P-loop domain ATPase PF06745.13 EMD67797.1 - 0.034 13.5 0.1 0.57 9.5 0.1 2.2 1 1 0 2 2 2 0 KaiC RNA_helicase PF00910.22 EMD67797.1 - 0.052 13.9 0.0 0.1 13.0 0.0 1.5 1 0 0 1 1 1 0 RNA helicase NACHT PF05729.12 EMD67797.1 - 0.053 13.4 0.2 0.63 9.9 0.1 2.3 1 1 1 2 2 2 0 NACHT domain PhoH PF02562.16 EMD67797.1 - 0.054 12.9 0.5 0.51 9.7 0.1 2.1 2 0 0 2 2 2 0 PhoH-like protein Mg_chelatase PF01078.21 EMD67797.1 - 0.06 12.7 0.1 0.12 11.7 0.1 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.12 EMD67797.1 - 0.062 12.6 0.0 0.18 11.1 0.0 1.7 2 0 0 2 2 2 0 Zeta toxin AAA_25 PF13481.6 EMD67797.1 - 0.074 12.6 1.2 0.58 9.7 0.4 2.5 1 1 1 2 2 2 0 AAA domain DUF2075 PF09848.9 EMD67797.1 - 0.13 11.4 0.0 0.19 10.9 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_7 PF12775.7 EMD67797.1 - 0.19 11.3 0.1 0.52 9.8 0.1 1.8 1 1 0 1 1 1 0 P-loop containing dynein motor region Prot_ATP_OB_N PF17758.1 EMD67797.1 - 0.2 11.3 0.9 1 9.0 0.0 2.4 2 0 0 2 2 2 0 Proteasomal ATPase OB N-terminal domain AAA_24 PF13479.6 EMD67797.1 - 0.46 10.2 2.7 0.29 10.8 0.3 2.0 2 1 0 2 2 2 0 AAA domain UQ_con PF00179.26 EMD67798.1 - 4.1e-43 146.4 0.0 5.8e-43 145.9 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UBA_3 PF09288.10 EMD67798.1 - 1.1e-05 25.1 0.1 2.5e-05 24.0 0.1 1.6 1 0 0 1 1 1 1 Fungal ubiquitin-associated domain RWD PF05773.22 EMD67798.1 - 0.023 15.0 0.0 0.037 14.3 0.0 1.4 1 0 0 1 1 1 0 RWD domain DRY_EERY PF09750.9 EMD67798.1 - 0.041 14.2 0.0 0.073 13.4 0.0 1.3 1 0 0 1 1 1 0 Alternative splicing regulator UBA PF00627.31 EMD67798.1 - 0.081 12.9 0.0 0.21 11.5 0.0 1.6 1 0 0 1 1 1 0 UBA/TS-N domain Esterase PF00756.20 EMD67799.1 - 1.7e-05 24.6 0.4 4.3e-05 23.3 0.2 1.7 1 1 0 1 1 1 1 Putative esterase COesterase PF00135.28 EMD67800.1 - 1.1e-53 182.9 0.0 1.4e-53 182.6 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EMD67800.1 - 6.3e-06 26.2 0.2 4.2e-05 23.5 0.2 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold FMO-like PF00743.19 EMD67801.1 - 0.00021 19.9 0.0 0.0004 18.9 0.0 1.4 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like 2-Hacid_dh_C PF02826.19 EMD67801.1 - 0.13 11.6 0.0 0.27 10.6 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Promethin PF16015.5 EMD67802.1 - 4.6e-30 103.7 13.2 5.7e-30 103.4 13.2 1.1 1 0 0 1 1 1 1 Promethin DUF2070 PF09843.9 EMD67802.1 - 2.3 6.4 8.7 3 6.0 8.7 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Ndc1_Nup PF09531.10 EMD67802.1 - 5.7 5.5 8.6 7.9 5.0 8.6 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup RNA_pol_I_A49 PF06870.12 EMD67803.1 - 3.9e-94 315.7 0.3 4.5e-94 315.5 0.3 1.0 1 0 0 1 1 1 1 A49-like RNA polymerase I associated factor DUF4615 PF15393.6 EMD67803.1 - 0.14 12.7 1.6 0.66 10.5 1.7 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4615) Herpes_LMP1 PF05297.11 EMD67804.1 - 4.2 6.5 5.4 4.7 6.3 5.4 1.0 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) DER1 PF04511.15 EMD67805.1 - 9.2e-30 104.0 3.5 1.1e-29 103.8 3.5 1.0 1 0 0 1 1 1 1 Der1-like family Bacteriocin_IIc PF10439.9 EMD67806.1 - 0.16 12.1 3.4 0.23 11.6 1.3 1.9 2 0 0 2 2 2 0 Bacteriocin class II with double-glycine leader peptide LRR_6 PF13516.6 EMD67807.1 - 0.0061 16.5 6.8 6.2 7.1 0.1 7.0 9 0 0 9 9 9 1 Leucine Rich repeat PH PF00169.29 EMD67807.1 - 0.0086 16.6 0.0 0.27 11.7 0.0 2.7 2 1 0 2 2 2 1 PH domain LRR_1 PF00560.33 EMD67807.1 - 0.019 15.4 7.2 31 5.7 0.0 7.8 10 0 0 10 10 10 0 Leucine Rich Repeat Pet127 PF08634.10 EMD67809.1 - 5e-114 380.4 0.1 8.5e-114 379.6 0.1 1.4 1 0 0 1 1 1 1 Mitochondrial protein Pet127 dsRBD2 PF17842.1 EMD67809.1 - 8 6.7 8.4 0.61 10.3 0.2 2.7 2 0 0 2 2 2 0 Double-stranded RNA binding domain 2 UBA_4 PF14555.6 EMD67810.1 - 0.00025 20.8 0.1 0.00056 19.7 0.1 1.6 1 0 0 1 1 1 1 UBA-like domain EzrA PF06160.12 EMD67810.1 - 0.26 9.4 3.1 0.42 8.7 3.1 1.2 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA adh_short_C2 PF13561.6 EMD67811.1 - 5.4e-56 189.8 0.2 6.9e-56 189.4 0.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EMD67811.1 - 6.9e-48 162.7 0.9 8.7e-48 162.4 0.9 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EMD67811.1 - 4.6e-12 46.2 0.3 6.2e-12 45.8 0.3 1.1 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 EMD67811.1 - 0.0049 16.3 0.0 0.0078 15.6 0.0 1.3 1 1 0 1 1 1 1 Fungal family of unknown function (DUF1776) Epimerase PF01370.21 EMD67811.1 - 0.012 15.1 0.1 0.017 14.6 0.1 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EMD67811.1 - 0.043 13.2 0.1 0.054 12.9 0.1 1.1 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase 3HCDH_N PF02737.18 EMD67811.1 - 0.053 13.4 1.6 0.088 12.7 0.9 1.6 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Glyco_hydro_61 PF03443.14 EMD67812.1 - 2.5e-45 154.9 2.7 3.1e-45 154.6 2.7 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 Cyclin_C_2 PF16899.5 EMD67814.1 - 8.8e-29 100.0 0.8 3e-28 98.2 0.1 2.1 2 0 0 2 2 2 1 Cyclin C-terminal domain Cyclin_N PF00134.23 EMD67814.1 - 4.3e-05 23.3 0.1 7.9e-05 22.4 0.1 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain DUF1682 PF07946.14 EMD67814.1 - 0.042 13.1 1.6 0.082 12.1 1.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) MMR_HSR1 PF01926.23 EMD67815.1 - 2.5e-17 63.0 0.2 4.4e-15 55.8 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase FeoB_N PF02421.18 EMD67815.1 - 1.5e-07 31.1 0.3 6.9e-06 25.7 0.0 2.4 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EMD67815.1 - 2.1e-05 24.5 2.0 0.0029 17.5 0.0 2.6 3 0 0 3 3 3 2 RsgA GTPase AIG1 PF04548.16 EMD67815.1 - 0.0056 16.0 0.6 0.011 15.0 0.1 1.8 2 0 0 2 2 2 1 AIG1 family Dynamin_N PF00350.23 EMD67815.1 - 0.021 14.9 8.2 0.21 11.6 0.3 3.8 3 1 1 4 4 4 0 Dynamin family LTV PF04180.14 EMD67816.1 - 9.9e-124 413.9 21.8 1.2e-123 413.7 21.8 1.0 1 0 0 1 1 1 1 Low temperature viability protein SPATIAL PF15256.6 EMD67816.1 - 0.083 13.2 0.2 0.19 12.1 0.2 1.6 1 0 0 1 1 1 0 SPATIAL His_Phos_2 PF00328.22 EMD67817.1 - 7.4e-12 45.3 0.5 1.7e-09 37.5 0.0 2.3 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 2) PIG-P PF08510.12 EMD67818.1 - 1.2e-50 170.4 0.8 2.1e-50 169.7 0.8 1.4 1 0 0 1 1 1 1 PIG-P DPM2 PF07297.12 EMD67818.1 - 0.23 11.8 7.3 0.39 11.1 7.3 1.2 1 0 0 1 1 1 0 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) Acyl-CoA_dh_1 PF00441.24 EMD67819.1 - 2.2e-27 96.1 0.4 3.6e-27 95.4 0.4 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 EMD67819.1 - 6.2e-21 74.4 0.0 1e-20 73.7 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 EMD67819.1 - 5.9e-17 62.3 0.2 2.9e-16 60.1 0.1 2.0 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 EMD67819.1 - 5.5e-10 39.6 0.4 9.4e-10 38.9 0.4 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Ogr_Delta PF04606.12 EMD67821.1 - 2.2 8.3 7.1 10 6.2 3.2 2.6 2 0 0 2 2 2 0 Ogr/Delta-like zinc finger Pkinase PF00069.25 EMD67824.1 - 6.4e-66 222.4 0.0 7.5e-66 222.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD67824.1 - 2.3e-24 86.1 0.0 3e-24 85.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMD67824.1 - 3.7e-06 26.5 0.0 1.7e-05 24.3 0.0 1.7 1 1 0 2 2 2 1 Kinase-like APH PF01636.23 EMD67824.1 - 0.0026 17.7 0.1 0.0086 16.0 0.0 1.8 2 1 0 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EMD67824.1 - 0.14 11.7 0.0 0.22 11.1 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase Kdo PF06293.14 EMD67824.1 - 0.16 11.3 0.0 0.28 10.5 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family MIF4G_like PF09088.11 EMD67825.1 - 1.2e-79 266.6 0.8 2.1e-79 265.8 0.8 1.4 1 0 0 1 1 1 1 MIF4G like MIF4G_like_2 PF09090.11 EMD67825.1 - 5.2e-70 236.0 0.2 7.5e-70 235.5 0.2 1.2 1 0 0 1 1 1 1 MIF4G like Mg_trans_NIPA PF05653.14 EMD67826.1 - 1.5e-60 204.8 1.1 4.5e-57 193.4 0.8 2.1 2 0 0 2 2 2 2 Magnesium transporter NIPA EamA PF00892.20 EMD67826.1 - 0.0034 17.6 1.4 0.0034 17.6 1.4 3.6 3 1 0 3 3 3 1 EamA-like transporter family CPP1-like PF11833.8 EMD67826.1 - 0.37 10.4 4.5 0.89 9.2 4.5 1.6 1 0 0 1 1 1 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like MDMPI_C PF07398.11 EMD67826.1 - 8.9 7.3 8.6 47 4.9 8.1 2.6 1 1 0 1 1 1 0 MDMPI C-terminal domain Peroxidase_2 PF01328.17 EMD67827.1 - 2.3e-46 158.7 0.0 2.8e-46 158.4 0.0 1.0 1 0 0 1 1 1 1 Peroxidase, family 2 Ank_2 PF12796.7 EMD67828.1 - 7.5e-24 84.1 3.4 6.1e-12 46.0 0.2 2.0 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMD67828.1 - 1.2e-20 73.5 0.4 3.4e-12 46.6 0.1 2.1 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMD67828.1 - 9.8e-18 62.4 0.0 1.6e-06 28.0 0.0 3.1 3 0 0 3 3 3 3 Ankyrin repeat Ank PF00023.30 EMD67828.1 - 1.1e-14 54.1 0.7 1.8e-05 25.0 0.0 3.2 2 1 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.6 EMD67828.1 - 5.6e-13 48.8 1.0 1.3e-05 25.4 0.2 2.6 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Pox_A12 PF04651.13 EMD67829.1 - 0.043 13.9 0.7 0.058 13.4 0.1 1.5 1 1 1 2 2 2 0 Poxvirus A12 protein Myb_DNA-binding PF00249.31 EMD67829.1 - 0.053 13.7 0.0 0.21 11.8 0.0 2.0 1 1 0 1 1 1 0 Myb-like DNA-binding domain ATP11 PF06644.11 EMD67829.1 - 0.18 11.6 3.1 0.2 11.4 3.1 1.1 1 0 0 1 1 1 0 ATP11 protein P21-Arc PF04062.14 EMD67831.1 - 5e-73 244.8 0.0 5.8e-73 244.6 0.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex ARPC3 (21 kDa) subunit AAA PF00004.29 EMD67832.1 - 5.4e-17 62.4 0.0 1e-16 61.6 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rep_fac_C PF08542.11 EMD67832.1 - 2e-16 60.2 0.0 6e-16 58.6 0.0 1.8 1 0 0 1 1 1 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.6 EMD67832.1 - 2.4e-12 46.9 0.0 8.3e-12 45.2 0.0 1.9 1 1 0 1 1 1 1 DNA polymerase III, delta subunit Rad17 PF03215.15 EMD67832.1 - 4.1e-08 33.3 0.0 7.5e-08 32.5 0.0 1.4 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_assoc_2 PF16193.5 EMD67832.1 - 6.8e-07 29.5 0.1 2.4e-06 27.8 0.0 2.0 2 1 0 2 2 1 1 AAA C-terminal domain AAA_5 PF07728.14 EMD67832.1 - 7e-07 29.3 0.1 4.3e-06 26.8 0.1 2.3 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_30 PF13604.6 EMD67832.1 - 1.5e-06 28.0 0.0 2.8e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EMD67832.1 - 2.3e-06 28.1 0.0 8.6e-06 26.2 0.0 2.1 1 1 0 1 1 1 1 AAA ATPase domain DNA_pol3_delta PF06144.13 EMD67832.1 - 2.4e-06 27.5 0.1 4.6e-06 26.5 0.1 1.4 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA_11 PF13086.6 EMD67832.1 - 3.3e-06 27.1 0.5 0.00019 21.3 0.0 2.2 1 1 1 2 2 2 1 AAA domain AAA_24 PF13479.6 EMD67832.1 - 8.4e-06 25.6 0.0 1.6e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EMD67832.1 - 1.2e-05 25.7 0.1 6.3e-05 23.3 0.1 2.2 1 1 0 1 1 1 1 AAA domain DUF815 PF05673.13 EMD67832.1 - 1.6e-05 24.2 0.0 3.4e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF815) RuvB_N PF05496.12 EMD67832.1 - 0.0001 22.1 0.0 0.00037 20.3 0.0 1.9 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_3 PF07726.11 EMD67832.1 - 0.00014 21.7 0.1 0.00043 20.1 0.1 1.9 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EMD67832.1 - 0.00033 20.4 0.0 0.00061 19.5 0.0 1.3 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_14 PF13173.6 EMD67832.1 - 0.00034 20.6 0.0 0.0014 18.6 0.0 1.9 1 1 1 2 2 2 1 AAA domain Mg_chelatase PF01078.21 EMD67832.1 - 0.00038 19.9 0.1 0.0081 15.6 0.1 2.6 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_19 PF13245.6 EMD67832.1 - 0.00048 20.5 0.1 0.0022 18.4 0.1 2.0 1 1 0 1 1 1 1 AAA domain ResIII PF04851.15 EMD67832.1 - 0.00064 19.8 0.0 0.056 13.4 0.0 2.2 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit PhoH PF02562.16 EMD67832.1 - 0.00083 18.9 0.0 0.2 11.1 0.0 2.4 2 0 0 2 2 2 1 PhoH-like protein DEAD PF00270.29 EMD67832.1 - 0.0009 19.0 0.1 0.008 16.0 0.0 2.1 1 1 1 2 2 2 1 DEAD/DEAH box helicase DUF2075 PF09848.9 EMD67832.1 - 0.005 16.1 0.0 0.0089 15.3 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_28 PF13521.6 EMD67832.1 - 0.012 15.9 0.0 0.026 14.8 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EMD67832.1 - 0.016 15.8 0.0 0.03 14.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 EMD67832.1 - 0.016 14.8 0.0 0.062 12.9 0.0 1.9 2 1 0 2 2 2 0 AAA domain TniB PF05621.11 EMD67832.1 - 0.018 14.5 0.0 0.13 11.7 0.0 2.1 2 0 0 2 2 2 0 Bacterial TniB protein AAA_7 PF12775.7 EMD67832.1 - 0.026 14.0 0.0 0.056 12.9 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region NACHT PF05729.12 EMD67832.1 - 0.034 14.0 0.0 0.071 13.0 0.0 1.5 1 0 0 1 1 1 0 NACHT domain ABC_tran PF00005.27 EMD67832.1 - 0.041 14.4 0.0 0.1 13.1 0.0 1.7 1 1 0 1 1 1 0 ABC transporter RNA_helicase PF00910.22 EMD67832.1 - 0.057 13.8 0.0 0.16 12.4 0.0 1.8 1 1 0 1 1 1 0 RNA helicase ATPase_2 PF01637.18 EMD67832.1 - 0.058 13.3 0.0 0.11 12.4 0.0 1.6 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea IstB_IS21 PF01695.17 EMD67832.1 - 0.091 12.5 0.0 0.49 10.1 0.0 2.1 1 1 0 1 1 1 0 IstB-like ATP binding protein TIP49 PF06068.13 EMD67832.1 - 0.093 11.9 0.0 0.21 10.8 0.0 1.5 1 0 0 1 1 1 0 TIP49 P-loop domain Nup88 PF10168.9 EMD67833.1 - 0.11 10.3 0.7 0.16 9.7 0.7 1.2 1 0 0 1 1 1 0 Nuclear pore component Pkinase PF00069.25 EMD67834.1 - 1.5e-63 214.7 0.0 1.7e-63 214.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD67834.1 - 1.6e-28 99.7 0.0 2.1e-28 99.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMD67834.1 - 0.0012 18.3 0.0 0.022 14.1 0.0 2.1 1 1 0 2 2 2 1 Kinase-like Kdo PF06293.14 EMD67834.1 - 0.017 14.4 0.0 0.029 13.7 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EMD67834.1 - 0.018 14.0 0.0 0.039 12.9 0.0 1.4 1 1 0 1 1 1 0 Haspin like kinase domain Pkinase_fungal PF17667.1 EMD67834.1 - 0.027 13.3 0.0 0.041 12.7 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase CMAS PF02353.20 EMD67835.1 - 8.2e-37 127.0 0.3 1.2e-36 126.5 0.3 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_31 PF13847.6 EMD67835.1 - 9.7e-17 61.2 0.0 1.4e-16 60.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMD67835.1 - 8.4e-15 55.3 0.0 1.4e-14 54.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMD67835.1 - 7.8e-14 52.1 0.0 1.3e-13 51.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EMD67835.1 - 1.2e-11 44.7 0.0 1.8e-11 44.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMD67835.1 - 8.2e-10 39.3 0.0 1.4e-09 38.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EMD67835.1 - 1.8e-07 30.9 0.0 3.3e-07 30.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_4 PF02390.17 EMD67835.1 - 3.2e-05 23.5 0.0 0.0001 21.9 0.0 1.7 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_2 PF00891.18 EMD67835.1 - 3.3e-05 23.3 0.0 5.1e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain Ubie_methyltran PF01209.18 EMD67835.1 - 8.7e-05 22.0 0.0 0.00013 21.4 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family PCMT PF01135.19 EMD67835.1 - 0.00011 22.0 0.0 0.00033 20.5 0.0 1.8 2 0 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) TehB PF03848.14 EMD67835.1 - 0.00012 21.5 0.0 0.00019 20.9 0.0 1.3 1 0 0 1 1 1 1 Tellurite resistance protein TehB GidB PF02527.15 EMD67835.1 - 0.0031 16.9 0.0 0.005 16.2 0.0 1.2 1 0 0 1 1 1 1 rRNA small subunit methyltransferase G Methyltr_RsmB-F PF01189.17 EMD67835.1 - 0.015 15.0 0.0 0.053 13.1 0.0 1.8 2 0 0 2 2 2 0 16S rRNA methyltransferase RsmB/F DUF938 PF06080.12 EMD67835.1 - 0.038 13.8 0.0 0.066 13.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF938) FtsJ PF01728.19 EMD67835.1 - 0.1 12.7 0.0 0.83 9.7 0.0 2.0 1 1 0 1 1 1 0 FtsJ-like methyltransferase AA_kinase PF00696.28 EMD67837.1 - 3.4e-40 138.1 0.1 5.1e-40 137.6 0.1 1.3 1 0 0 1 1 1 1 Amino acid kinase family ACT_7 PF13840.6 EMD67837.1 - 8.3e-09 35.1 0.9 1.6e-07 31.0 0.1 2.5 2 0 0 2 2 2 1 ACT domain ACT PF01842.25 EMD67837.1 - 2.2e-07 30.5 0.4 4.1e-06 26.5 0.1 2.5 2 0 0 2 2 2 1 ACT domain DUF3492 PF11997.8 EMD67837.1 - 0.029 14.1 0.0 0.046 13.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3492) CRT10 PF08728.10 EMD67838.1 - 0.13 10.4 1.1 0.18 9.9 1.1 1.1 1 0 0 1 1 1 0 CRT10 MINDY_DUB PF04424.13 EMD67839.1 - 3.6e-24 85.0 0.0 6.6e-24 84.2 0.0 1.4 1 0 0 1 1 1 1 MINDY deubiquitinase CCDC50_N PF15295.6 EMD67839.1 - 0.093 12.9 2.1 0.21 11.7 2.1 1.6 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 50 N-terminus Gcd10p PF04189.13 EMD67840.1 - 4.4e-119 397.1 0.0 9.6e-119 395.9 0.0 1.5 2 0 0 2 2 2 1 Gcd10p family LsmAD PF06741.13 EMD67840.1 - 0.038 14.5 0.2 0.14 12.8 0.2 1.9 1 0 0 1 1 1 0 LsmAD domain S-antigen PF05756.11 EMD67840.1 - 4.4 7.7 5.0 79 3.7 0.0 3.2 3 0 0 3 3 3 0 S-antigen protein Mt_ATP-synt_D PF05873.12 EMD67841.1 - 0.0029 17.5 5.9 0.0029 17.5 5.9 3.0 3 0 0 3 3 3 1 ATP synthase D chain, mitochondrial (ATP5H) Peptidase_S24 PF00717.23 EMD67841.1 - 0.096 12.7 0.0 0.2 11.6 0.0 1.5 1 0 0 1 1 1 0 Peptidase S24-like Beta-lactamase PF00144.24 EMD67843.1 - 4.3e-42 144.5 0.0 5.4e-42 144.2 0.0 1.1 1 0 0 1 1 1 1 Beta-lactamase Peptidase_S11 PF00768.20 EMD67843.1 - 0.049 13.1 0.1 0.12 11.8 0.0 1.6 2 0 0 2 2 2 0 D-alanyl-D-alanine carboxypeptidase Beta-lactamase2 PF13354.6 EMD67843.1 - 0.12 12.0 0.0 6.3 6.3 0.0 2.3 2 0 0 2 2 2 0 Beta-lactamase enzyme family Esterase_phd PF10503.9 EMD67845.1 - 0.00013 21.6 0.0 0.00023 20.7 0.0 1.4 1 0 0 1 1 1 1 Esterase PHB depolymerase Peptidase_S9 PF00326.21 EMD67845.1 - 0.001 18.6 0.1 0.016 14.6 0.0 2.4 1 1 1 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_2 PF02230.16 EMD67845.1 - 0.0055 16.5 0.0 0.012 15.4 0.0 1.6 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase AXE1 PF05448.12 EMD67845.1 - 0.0084 14.8 0.1 0.14 10.8 0.0 2.4 3 0 0 3 3 3 1 Acetyl xylan esterase (AXE1) Abhydrolase_3 PF07859.13 EMD67845.1 - 0.13 12.2 0.0 0.2 11.5 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Peptidase_M22 PF00814.25 EMD67846.1 - 3.4e-81 272.9 0.0 4e-81 272.7 0.0 1.0 1 0 0 1 1 1 1 Glycoprotease family Carbam_trans_N PF02543.15 EMD67846.1 - 0.0044 16.7 0.0 0.63 9.6 0.0 2.2 2 0 0 2 2 2 2 Carbamoyltransferase N-terminus SET PF00856.28 EMD67847.1 - 1.7e-22 80.6 0.0 5e-22 79.1 0.0 1.8 2 1 0 2 2 2 1 SET domain Rubis-subs-bind PF09273.11 EMD67847.1 - 4.6e-12 46.8 0.7 1.1e-11 45.5 0.7 1.6 1 0 0 1 1 1 1 Rubisco LSMT substrate-binding EPL1 PF10513.9 EMD67848.1 - 5.6e-27 95.0 0.1 1.3e-26 93.9 0.1 1.6 1 0 0 1 1 1 1 Enhancer of polycomb-like Latarcin PF10279.9 EMD67848.1 - 0.85 10.1 6.3 0.57 10.6 2.6 2.3 2 0 0 2 2 2 0 Latarcin precursor D123 PF07065.14 EMD67850.1 - 0.00091 18.5 0.7 0.00091 18.5 0.7 1.1 1 0 0 1 1 1 1 D123 Ribosomal_L6e PF01159.19 EMD67850.1 - 1.5 9.4 6.5 0.61 10.6 3.9 1.6 2 0 0 2 2 2 0 Ribosomal protein L6e F-box-like PF12937.7 EMD67851.1 - 0.066 13.1 0.0 0.14 12.1 0.0 1.6 1 0 0 1 1 1 0 F-box-like F-box-like PF12937.7 EMD67852.1 - 0.09 12.7 0.0 0.2 11.6 0.0 1.6 1 0 0 1 1 1 0 F-box-like Pkinase PF00069.25 EMD67853.1 - 6.5e-23 81.4 0.0 9.5e-23 80.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD67853.1 - 1.2e-06 28.1 0.0 1.8e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Gly_transf_sug PF04488.15 EMD67854.1 - 1.4e-20 73.7 0.0 2.7e-20 72.8 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif TcdA_TcdB PF12919.7 EMD67854.1 - 0.3 10.3 1.7 0.87 8.8 0.2 1.9 2 0 0 2 2 2 0 TcdA/TcdB catalytic glycosyltransferase domain EMP70 PF02990.16 EMD67856.1 - 8.8 4.9 8.4 11 4.5 8.4 1.1 1 0 0 1 1 1 0 Endomembrane protein 70 AMPKBI PF04739.15 EMD67857.1 - 4.3e-24 84.6 1.0 2.3e-23 82.2 1.0 2.4 1 0 0 1 1 1 1 5'-AMP-activated protein kinase beta subunit, interaction domain AMPK1_CBM PF16561.5 EMD67857.1 - 1e-23 83.3 0.0 1.8e-23 82.5 0.0 1.4 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase UFD1 PF03152.14 EMD67859.1 - 2.8e-73 245.0 0.0 3.5e-73 244.7 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 GYF PF02213.16 EMD67860.1 - 2.4e-10 39.9 0.3 5.3e-10 38.8 0.3 1.6 1 0 0 1 1 1 1 GYF domain GYF_2 PF14237.6 EMD67860.1 - 0.017 14.9 0.3 0.043 13.6 0.3 1.7 1 0 0 1 1 1 0 GYF domain 2 Transglut_prok PF09017.10 EMD67861.1 - 0.13 11.6 0.0 0.17 11.2 0.0 1.2 1 0 0 1 1 1 0 Microbial transglutaminase R3H PF01424.22 EMD67862.1 - 2.5e-09 37.0 0.0 5.5e-09 35.9 0.0 1.6 1 0 0 1 1 1 1 R3H domain RRM_1 PF00076.22 EMD67862.1 - 4.9e-06 26.3 0.1 1.2e-05 25.1 0.1 1.7 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HSF_DNA-bind PF00447.17 EMD67863.1 - 2.4e-28 98.6 0.6 5.8e-28 97.4 0.6 1.7 1 0 0 1 1 1 1 HSF-type DNA-binding Ets PF00178.22 EMD67863.1 - 0.035 14.6 0.0 0.092 13.2 0.0 1.6 1 0 0 1 1 1 0 Ets-domain DUF1828 PF08861.10 EMD67863.1 - 0.086 13.1 0.5 36 4.7 0.0 3.3 3 0 0 3 3 3 0 Domain of unknown function DUF1828 PAXIP1_C PF15364.6 EMD67863.1 - 1.4 9.3 10.6 1.9 8.8 1.4 3.4 3 0 0 3 3 3 0 PAXIP1-associated-protein-1 C term PTIP binding protein P5-ATPase PF12409.8 EMD67864.1 - 6.9e-41 139.3 0.0 1.6e-40 138.1 0.0 1.7 1 0 0 1 1 1 1 P5-type ATPase cation transporter E1-E2_ATPase PF00122.20 EMD67864.1 - 2.3e-32 111.9 0.6 1.5e-31 109.3 0.0 2.2 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 EMD67864.1 - 2.3e-15 57.5 0.1 1e-06 29.2 0.0 3.3 3 0 0 3 3 3 3 haloacid dehalogenase-like hydrolase Cation_ATPase_C PF00689.21 EMD67864.1 - 0.00014 21.6 8.9 0.00014 21.6 8.9 2.0 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.6 EMD67864.1 - 0.0017 18.4 0.0 0.004 17.2 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 EMD67864.1 - 0.0095 15.6 0.0 0.023 14.4 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Mpv17_PMP22 PF04117.12 EMD67864.1 - 0.14 12.4 3.5 4.8 7.5 0.4 2.8 2 0 0 2 2 2 0 Mpv17 / PMP22 family Hydrolase_3 PF08282.12 EMD67864.1 - 0.18 11.5 0.0 11 5.7 0.0 2.2 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase Abhydrolase_3 PF07859.13 EMD67865.1 - 4.4e-41 141.1 0.0 5.4e-41 140.8 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EMD67865.1 - 0.00044 19.8 0.0 0.00077 19.0 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family COesterase PF00135.28 EMD67865.1 - 0.0012 17.8 0.3 0.0028 16.6 0.3 1.5 1 1 0 1 1 1 1 Carboxylesterase family DUF2920 PF11144.8 EMD67865.1 - 0.0026 17.0 0.0 0.12 11.5 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF2920) Sugarporin_N PF11471.8 EMD67866.1 - 0.0061 16.5 1.6 0.0061 16.5 1.6 3.4 3 1 1 4 4 4 2 Maltoporin periplasmic N-terminal extension DUF3040 PF11239.8 EMD67866.1 - 0.34 11.2 2.5 19 5.6 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3040) STE3 PF02076.15 EMD67867.1 - 9.6e-78 261.3 29.7 1.3e-77 260.8 29.7 1.2 1 0 0 1 1 1 1 Pheromone A receptor Pkinase PF00069.25 EMD67867.1 - 3e-58 197.3 0.0 4.5e-58 196.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD67867.1 - 5.5e-30 104.5 0.1 1.6e-29 103.0 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EMD67867.1 - 6.3e-06 25.4 0.2 1.2e-05 24.4 0.2 1.4 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EMD67867.1 - 9e-05 21.9 0.2 0.00049 19.5 0.0 2.1 2 1 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family FHA PF00498.26 EMD67867.1 - 0.0032 17.8 0.0 0.0077 16.6 0.0 1.7 1 0 0 1 1 1 1 FHA domain YrbL-PhoP_reg PF10707.9 EMD67867.1 - 0.03 13.9 0.0 0.065 12.7 0.0 1.5 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Pkinase_fungal PF17667.1 EMD67867.1 - 0.036 12.8 0.0 0.065 12.0 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase APH PF01636.23 EMD67867.1 - 0.049 13.6 0.0 0.091 12.7 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family FAD_binding_3 PF01494.19 EMD67869.1 - 3.5e-27 95.6 0.0 5.7e-27 94.9 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain HET PF06985.11 EMD67870.1 - 1.5e-31 109.7 0.5 2.5e-30 105.8 0.1 2.3 2 0 0 2 2 2 1 Heterokaryon incompatibility protein (HET) ketoacyl-synt PF00109.26 EMD67872.1 - 7.5e-61 205.9 0.0 1.7e-60 204.8 0.0 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.10 EMD67872.1 - 7.6e-54 182.3 0.4 2.5e-53 180.7 0.4 2.0 1 0 0 1 1 1 1 KR domain PS-DH PF14765.6 EMD67872.1 - 5.3e-51 173.6 0.0 9.9e-51 172.7 0.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 EMD67872.1 - 1.1e-49 169.7 0.0 9.6e-49 166.6 0.0 2.1 2 0 0 2 2 2 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EMD67872.1 - 3.3e-32 111.0 0.5 1.2e-31 109.2 0.5 2.0 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 EMD67872.1 - 1.1e-20 74.1 0.0 2.7e-20 72.9 0.0 1.7 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension ADH_zinc_N_2 PF13602.6 EMD67872.1 - 1.2e-18 68.5 0.0 3.3e-18 67.0 0.0 1.9 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 EMD67872.1 - 7.9e-18 64.7 0.0 3e-17 62.8 0.0 2.0 1 0 0 1 1 1 1 Zinc-binding dehydrogenase adh_short PF00106.25 EMD67872.1 - 2.6e-09 36.8 2.5 7.7e-08 32.0 0.2 3.6 4 0 0 4 4 4 1 short chain dehydrogenase PP-binding PF00550.25 EMD67872.1 - 8.9e-07 29.2 0.1 2.3e-06 27.9 0.1 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site SAT PF16073.5 EMD67872.1 - 1.2e-05 25.2 0.2 0.00023 21.0 0.2 2.3 1 1 0 1 1 1 1 Starter unit:ACP transacylase in aflatoxin biosynthesis adh_short_C2 PF13561.6 EMD67872.1 - 2e-05 24.3 0.2 0.0001 22.0 0.1 2.1 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase ADH_N PF08240.12 EMD67872.1 - 0.00017 21.4 0.1 0.00038 20.3 0.1 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Hydrolase_4 PF12146.8 EMD67873.1 - 1.6e-10 40.7 0.0 1.1e-09 38.0 0.0 1.9 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EMD67873.1 - 2.2e-10 40.6 0.0 8.8e-09 35.4 0.0 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold AXE1 PF05448.12 EMD67873.1 - 7e-10 38.1 0.0 7.4e-07 28.1 0.0 2.5 2 1 1 3 3 3 2 Acetyl xylan esterase (AXE1) Peptidase_S9 PF00326.21 EMD67873.1 - 1.9e-08 34.1 0.0 1.5e-06 27.9 0.0 2.1 2 0 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 EMD67873.1 - 3.7e-08 34.2 0.0 5e-08 33.8 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S15 PF02129.18 EMD67873.1 - 5.1e-07 29.6 0.0 9.4e-07 28.7 0.0 1.3 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) BAAT_C PF08840.11 EMD67873.1 - 0.00032 20.7 0.0 0.00061 19.8 0.0 1.4 1 0 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal DLH PF01738.18 EMD67873.1 - 0.00039 20.0 0.0 0.015 14.9 0.0 2.7 2 1 0 2 2 2 1 Dienelactone hydrolase family DUF1100 PF06500.11 EMD67873.1 - 0.0012 17.7 0.0 0.013 14.3 0.0 1.9 2 0 0 2 2 2 1 Alpha/beta hydrolase of unknown function (DUF1100) LIP PF03583.14 EMD67873.1 - 0.13 11.6 0.2 0.9 8.8 0.0 2.2 3 0 0 3 3 3 0 Secretory lipase MFS_1 PF07690.16 EMD67874.1 - 6.2e-42 143.8 48.5 6.2e-42 143.8 48.5 1.8 2 0 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EMD67874.1 - 6.5e-13 48.0 15.5 6.5e-13 48.0 15.5 1.6 1 1 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) p450 PF00067.22 EMD67875.1 - 1.4e-55 188.9 0.0 1.9e-55 188.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 FAM165 PF14981.6 EMD67875.1 - 1.6 8.6 3.4 3.1 7.7 3.4 1.4 1 0 0 1 1 1 0 FAM165 family adh_short PF00106.25 EMD67876.1 - 1.8e-22 79.8 0.1 2.3e-22 79.4 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD67876.1 - 1.1e-16 61.1 0.4 1.4e-16 60.8 0.4 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.6 EMD67876.1 - 0.00067 19.6 0.0 0.0011 18.9 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EMD67876.1 - 0.0015 18.2 0.1 0.76 9.3 0.0 2.2 1 1 1 2 2 2 2 NmrA-like family Epimerase PF01370.21 EMD67876.1 - 0.007 15.8 0.0 0.0096 15.4 0.0 1.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family FAD_binding_4 PF01565.23 EMD67877.1 - 2.9e-20 72.4 1.5 5.7e-20 71.5 1.5 1.5 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EMD67877.1 - 1e-07 31.9 0.4 2.6e-07 30.6 0.4 1.6 1 0 0 1 1 1 1 Berberine and berberine like Ank_4 PF13637.6 EMD67878.1 - 1.2e-13 51.2 0.3 5.9e-09 36.3 0.1 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EMD67878.1 - 1.5e-11 44.7 0.0 1.1e-10 41.9 0.0 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EMD67878.1 - 4.3e-09 35.9 0.1 0.008 16.6 0.0 3.5 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 EMD67878.1 - 2.3e-07 31.0 0.4 0.0001 22.6 0.2 3.4 3 0 0 3 3 3 1 Ankyrin repeat Ank_5 PF13857.6 EMD67878.1 - 1.9e-05 24.8 0.1 0.0074 16.6 0.0 2.9 1 1 2 3 3 3 2 Ankyrin repeats (many copies) bZIP_1 PF00170.21 EMD67878.1 - 0.32 11.1 9.9 0.53 10.4 9.9 1.3 1 0 0 1 1 1 0 bZIP transcription factor Exo_endo_phos_2 PF14529.6 EMD67879.1 - 0.0043 16.9 1.8 0.0068 16.2 1.8 1.4 1 1 0 1 1 1 1 Endonuclease-reverse transcriptase p450 PF00067.22 EMD67880.1 - 3e-75 253.7 0.0 4.3e-75 253.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 FAD_binding_1 PF00667.20 EMD67880.1 - 2.5e-31 109.0 0.0 3.7e-31 108.4 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 EMD67880.1 - 3.5e-21 75.9 0.0 4.7e-20 72.3 0.0 2.3 2 0 0 2 2 2 1 Flavodoxin NAD_binding_1 PF00175.21 EMD67880.1 - 9.2e-15 55.2 0.0 2e-14 54.1 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Flavodoxin_5 PF12724.7 EMD67880.1 - 0.0012 19.0 0.0 0.0026 18.0 0.0 1.5 1 0 0 1 1 1 1 Flavodoxin domain FMN_red PF03358.15 EMD67880.1 - 0.18 11.5 0.0 0.38 10.5 0.0 1.5 1 0 0 1 1 1 0 NADPH-dependent FMN reductase ADH_N PF08240.12 EMD67882.1 - 4.7e-14 52.2 1.4 4.7e-14 52.2 1.4 1.7 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain XdhC_C PF13478.6 EMD67882.1 - 0.0027 18.2 0.1 0.004 17.7 0.1 1.2 1 0 0 1 1 1 1 XdhC Rossmann domain RNase_H PF00075.24 EMD67884.1 - 4.6e-05 23.6 0.1 7.8e-05 22.9 0.1 1.4 1 0 0 1 1 1 1 RNase H DUF3018 PF11455.8 EMD67884.1 - 0.093 12.7 0.0 0.18 11.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3018) DUF4275 PF14101.6 EMD67884.1 - 0.15 12.2 0.0 0.2 11.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4275) HTH_37 PF13744.6 EMD67885.1 - 0.00021 21.2 0.2 0.0003 20.7 0.2 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain G-gamma PF00631.22 EMD67885.1 - 0.047 13.7 0.6 0.069 13.2 0.6 1.2 1 0 0 1 1 1 0 GGL domain DUF2797 PF10977.8 EMD67886.1 - 0.89 9.4 4.7 1.1 9.0 4.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2797) Zn_clus PF00172.18 EMD67886.1 - 2.2 8.5 12.0 0.89 9.7 7.8 2.3 2 1 0 2 2 2 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Transferase PF02458.15 EMD67887.1 - 2.1e-21 76.1 0.0 1.2e-20 73.7 0.0 1.8 1 1 0 1 1 1 1 Transferase family Condensation PF00668.20 EMD67887.1 - 0.012 14.4 0.0 0.021 13.5 0.0 1.3 1 0 0 1 1 1 0 Condensation domain p450 PF00067.22 EMD67888.1 - 4.1e-69 233.5 0.0 5.2e-69 233.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DDE_1 PF03184.19 EMD67889.1 - 0.00016 21.4 0.0 0.0002 21.1 0.0 1.3 1 1 0 1 1 1 1 DDE superfamily endonuclease Aldo_ket_red PF00248.21 EMD67890.1 - 6.8e-41 140.4 0.0 7.8e-41 140.2 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family HTH_psq PF05225.16 EMD67891.1 - 0.012 15.4 0.0 0.02 14.6 0.0 1.4 1 0 0 1 1 1 0 helix-turn-helix, Psq domain SpoIIID PF12116.8 EMD67891.1 - 0.076 13.1 0.1 0.25 11.5 0.0 1.8 2 0 0 2 2 2 0 Stage III sporulation protein D HTH_50 PF18024.1 EMD67891.1 - 0.081 12.5 0.0 0.38 10.4 0.0 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain FAD_binding_4 PF01565.23 EMD67894.1 - 7.1e-17 61.4 0.1 9.8e-17 61.0 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain ALO PF04030.14 EMD67894.1 - 0.09 12.6 0.0 9.5 5.9 0.0 2.3 2 0 0 2 2 2 0 D-arabinono-1,4-lactone oxidase polyprenyl_synt PF00348.17 EMD67895.1 - 8.9e-22 77.4 0.0 3.3e-21 75.5 0.0 1.8 2 0 0 2 2 2 1 Polyprenyl synthetase Glyco_hydro_18 PF00704.28 EMD67895.1 - 1.4e-05 24.9 0.3 8.9e-05 22.4 0.1 2.1 2 0 0 2 2 2 1 Glycosyl hydrolases family 18 adh_short PF00106.25 EMD67897.1 - 1e-42 145.9 0.9 1.3e-42 145.5 0.9 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD67897.1 - 1.7e-31 109.6 0.2 2.3e-31 109.2 0.2 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD67897.1 - 5.2e-10 39.5 2.0 1.1e-09 38.4 2.0 1.5 1 1 0 1 1 1 1 KR domain Cyclin_N PF00134.23 EMD67899.1 - 4.4e-14 52.3 0.0 1.1e-13 51.1 0.0 1.6 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin PF08613.11 EMD67899.1 - 9.2e-10 39.1 0.1 3e-09 37.4 0.0 1.9 2 0 0 2 2 2 1 Cyclin Pkinase PF00069.25 EMD67902.1 - 4e-65 219.8 0.0 5.5e-65 219.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD67902.1 - 4.3e-32 111.4 0.0 2.3e-31 109.0 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EMD67902.1 - 0.0043 16.4 0.0 0.0072 15.7 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EMD67902.1 - 0.0065 15.8 0.1 0.048 13.0 0.0 2.2 2 1 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 EMD67902.1 - 0.01 14.8 0.1 0.01 14.8 0.1 1.5 2 0 0 2 2 2 0 Haspin like kinase domain FTA2 PF13095.6 EMD67902.1 - 0.012 15.2 0.1 2.6 7.6 0.0 2.3 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 EMD67902.1 - 0.018 15.0 0.2 0.039 13.9 0.2 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family GCFC PF07842.12 EMD67904.1 - 4.9e-59 200.2 1.1 7.5e-59 199.6 1.1 1.2 1 0 0 1 1 1 1 GC-rich sequence DNA-binding factor-like protein G-patch PF01585.23 EMD67904.1 - 6.2e-11 42.0 6.5 1.5e-10 40.8 6.5 1.7 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 EMD67904.1 - 0.00026 21.0 2.5 0.00026 21.0 2.5 2.1 2 0 0 2 2 2 1 G-patch domain DUF2397 PF09660.10 EMD67904.1 - 0.064 12.2 0.1 0.064 12.2 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2397) DASH_Dam1 PF08653.10 EMD67904.1 - 0.15 11.9 0.2 2.7 7.9 0.0 2.6 3 0 0 3 3 3 0 DASH complex subunit Dam1 Exonuc_VII_L PF02601.15 EMD67904.1 - 1.9 7.9 4.6 0.19 11.2 0.1 1.6 2 0 0 2 2 2 0 Exonuclease VII, large subunit V_ATPase_I PF01496.19 EMD67905.1 - 5.3 4.8 5.6 10 3.9 3.6 2.0 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Sod_Fe_C PF02777.18 EMD67906.1 - 3.8e-38 129.7 2.2 5.5e-38 129.2 0.5 1.9 2 0 0 2 2 2 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 EMD67906.1 - 9e-28 96.6 2.2 1.6e-27 95.8 2.2 1.4 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain Acetyltransf_8 PF13523.6 EMD67907.1 - 2.6e-50 169.9 0.1 4.1e-50 169.2 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 EMD67907.1 - 0.046 14.4 0.1 0.11 13.2 0.1 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Antimicrobial10 PF08105.11 EMD67907.1 - 0.43 10.7 0.0 0.43 10.7 0.0 2.3 2 0 0 2 2 2 0 Metchnikowin family PBP_N PF17093.5 EMD67907.1 - 0.86 9.9 10.8 3.6 7.9 5.3 2.5 1 1 1 2 2 2 0 Penicillin-binding protein N-terminus Lyase_1 PF00206.20 EMD67908.1 - 1.2e-19 70.9 0.0 1.9e-19 70.3 0.0 1.3 1 0 0 1 1 1 1 Lyase ADSL_C PF10397.9 EMD67908.1 - 7.8e-16 58.4 0.0 3.2e-15 56.4 0.0 2.1 1 0 0 1 1 1 1 Adenylosuccinate lyase C-terminus CHCH PF06747.13 EMD67910.1 - 0.0025 17.9 1.1 0.0032 17.6 1.1 1.2 1 0 0 1 1 1 1 CHCH domain DUF4690 PF15756.5 EMD67912.1 - 0.0081 16.7 0.1 0.019 15.5 0.1 1.6 1 0 0 1 1 1 1 Small Novel Rich in Cartilage Podoplanin PF05808.11 EMD67912.1 - 0.43 10.7 5.8 0.74 9.9 5.1 1.8 1 1 1 2 2 2 0 Podoplanin zf-CCCH_4 PF18044.1 EMD67913.1 - 0.00041 20.1 5.8 0.00041 20.1 5.8 2.2 2 0 0 2 2 2 1 CCCH-type zinc finger zf-CCCH PF00642.24 EMD67913.1 - 0.00047 20.0 5.9 0.00047 20.0 5.9 3.3 3 1 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 EMD67913.1 - 0.0094 16.6 0.1 0.0094 16.6 0.1 2.1 2 0 0 2 2 2 1 Torus domain zf-CCCH_3 PF15663.5 EMD67913.1 - 0.023 14.9 5.7 0.81 9.9 1.5 2.6 2 1 0 2 2 2 0 Zinc-finger containing family EzrA PF06160.12 EMD67913.1 - 0.064 11.4 0.1 0.11 10.6 0.1 1.3 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA zf-PHD-like PF15446.6 EMD67914.1 - 8e-70 233.8 10.4 1.7e-69 232.8 10.4 1.6 1 0 0 1 1 1 1 PHD/FYVE-zinc-finger like domain SNF2_N PF00176.23 EMD67914.1 - 1.3e-51 175.4 0.0 2.2e-51 174.7 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain zf-CCCH_6 PF18585.1 EMD67914.1 - 4.7e-27 93.6 0.3 1.2e-26 92.4 0.3 1.7 1 0 0 1 1 1 1 Chromatin remodeling factor Mit1 C-terminal Zn finger 2 Helicase_C PF00271.31 EMD67914.1 - 1.2e-19 70.7 0.0 2.8e-19 69.5 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HDA2-3 PF11496.8 EMD67914.1 - 1.7e-09 37.3 0.1 3.6e-09 36.2 0.1 1.4 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 ResIII PF04851.15 EMD67914.1 - 7.2e-07 29.4 0.0 1.5e-06 28.3 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Chromo PF00385.24 EMD67914.1 - 3.3e-06 26.9 0.1 0.49 10.3 0.2 3.7 3 0 0 3 3 3 2 Chromo (CHRromatin Organisation MOdifier) domain PHD PF00628.29 EMD67914.1 - 0.00032 20.5 3.5 0.00032 20.5 3.5 3.4 3 2 0 3 3 3 2 PHD-finger Toxin_36 PF10550.9 EMD67914.1 - 0.33 12.4 2.6 1.8 10.1 2.6 2.4 1 0 0 1 1 1 0 Conantokin-G mollusc-toxin Zf_RING PF16744.5 EMD67914.1 - 0.72 10.0 9.4 3.7 7.7 2.8 2.8 2 0 0 2 2 2 0 KIAA1045 RING finger Fer4_8 PF13183.6 EMD67914.1 - 5.1 7.6 11.6 0.17 12.4 1.6 3.5 4 0 0 4 4 3 0 4Fe-4S dicluster domain SpoU_methylase PF00588.19 EMD67915.1 - 1e-23 84.0 0.0 2.2e-23 83.0 0.0 1.6 1 0 0 1 1 1 1 SpoU rRNA Methylase family SpoU_sub_bind PF08032.12 EMD67915.1 - 2.8e-05 24.3 0.0 0.00012 22.3 0.0 2.0 1 1 0 1 1 1 1 RNA 2'-O ribose methyltransferase substrate binding L_HMGIC_fpl PF10242.9 EMD67916.1 - 2.9e-05 24.4 4.3 2.9e-05 24.4 4.3 1.6 2 1 0 2 2 2 1 Lipoma HMGIC fusion partner-like protein Claudin_3 PF06653.11 EMD67916.1 - 0.21 11.5 9.8 1.8 8.5 4.2 2.8 2 1 0 2 2 2 0 Tight junction protein, Claudin-like DUF5336 PF17270.2 EMD67916.1 - 1.8 8.1 4.5 4.1 7.0 4.5 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5336) Ribosomal_L6e PF01159.19 EMD67917.1 - 2.3e-36 124.7 0.2 2.3e-36 124.7 0.2 1.4 2 0 0 2 2 2 1 Ribosomal protein L6e p450 PF00067.22 EMD67918.1 - 2.8e-56 191.2 0.0 4e-56 190.7 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 BIRC6 PF12356.8 EMD67920.1 - 0.026 14.0 0.1 0.026 14.0 0.1 1.1 1 0 0 1 1 1 0 Baculoviral IAP repeat-containing protein 6 Aa_trans PF01490.18 EMD67921.1 - 6.4e-82 275.4 26.7 7.4e-82 275.2 26.7 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein PhoLip_ATPase_C PF16212.5 EMD67921.1 - 0.031 14.0 13.4 0.09 12.5 8.3 2.3 2 0 0 2 2 2 0 Phospholipid-translocating P-type ATPase C-terminal Acetyltransf_1 PF00583.25 EMD67922.1 - 3.9e-14 52.9 0.0 5.2e-14 52.5 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EMD67922.1 - 8.8e-08 32.1 0.0 2e-07 31.0 0.0 1.6 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EMD67922.1 - 1.2e-07 32.1 0.0 1.6e-07 31.6 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EMD67922.1 - 0.012 15.5 0.0 0.022 14.7 0.0 1.4 1 0 0 1 1 1 0 FR47-like protein INCENP_ARK-bind PF03941.15 EMD67924.1 - 4.4e-17 61.8 1.3 4.4e-17 61.8 1.3 3.7 3 0 0 3 3 3 1 Inner centromere protein, ARK binding region MARVEL PF01284.23 EMD67925.1 - 1.1e-22 80.6 13.5 1.4e-22 80.3 13.5 1.0 1 0 0 1 1 1 1 Membrane-associating domain ComS PF17584.2 EMD67925.1 - 0.12 11.9 1.2 0.3 10.7 1.2 1.6 1 0 0 1 1 1 0 Bacillus competence protein S PSP1 PF04468.12 EMD67928.1 - 7.7e-22 77.4 0.2 1.5e-21 76.4 0.2 1.5 1 0 0 1 1 1 1 PSP1 C-terminal conserved region Ribosomal_L15e PF00827.17 EMD67930.1 - 6.1e-87 290.3 10.7 7.6e-87 290.0 10.7 1.0 1 0 0 1 1 1 1 Ribosomal L15 PT PF04886.12 EMD67930.1 - 0.13 11.8 0.4 0.22 11.1 0.4 1.2 1 0 0 1 1 1 0 PT repeat DnaJ PF00226.31 EMD67931.1 - 1e-21 76.8 0.2 2.4e-21 75.6 0.2 1.7 1 0 0 1 1 1 1 DnaJ domain Glyco_hydro_43 PF04616.14 EMD67933.1 - 4.4e-28 98.4 2.2 3.2e-27 95.6 2.2 2.3 1 1 0 1 1 1 1 Glycosyl hydrolases family 43 MOSC PF03473.17 EMD67934.1 - 2.1e-28 98.9 0.0 3e-28 98.5 0.0 1.2 1 0 0 1 1 1 1 MOSC domain MOSC_N PF03476.16 EMD67934.1 - 8.3e-20 70.9 0.0 1.4e-19 70.1 0.0 1.3 1 0 0 1 1 1 1 MOSC N-terminal beta barrel domain GDE_C PF06202.14 EMD67936.1 - 0.018 14.0 0.0 0.025 13.5 0.0 1.1 1 0 0 1 1 1 0 Amylo-alpha-1,6-glucosidase ING PF12998.7 EMD67937.1 - 7.3e-05 23.3 0.0 0.00029 21.4 0.0 2.1 1 1 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 EMD67937.1 - 0.001 18.9 8.2 0.0018 18.1 8.2 1.4 1 0 0 1 1 1 1 PHD-finger zf-HC5HC2H PF13771.6 EMD67937.1 - 0.0067 16.7 1.5 0.015 15.5 1.5 1.5 1 0 0 1 1 1 1 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 EMD67937.1 - 0.028 14.6 0.3 0.055 13.6 0.3 1.4 1 0 0 1 1 1 0 PHD-zinc-finger like domain Na_trans_assoc PF06512.13 EMD67937.1 - 0.6 10.4 14.2 0.049 13.9 4.4 2.5 2 0 0 2 2 2 0 Sodium ion transport-associated 5_nucleotid_C PF02872.18 EMD67938.1 - 5.6e-40 137.1 0.0 9.4e-40 136.4 0.0 1.3 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Metallophos PF00149.28 EMD67938.1 - 7.1e-05 23.4 0.1 0.00014 22.5 0.1 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Uds1 PF15456.6 EMD67939.1 - 2.4e-37 128.0 1.0 2.4e-37 128.0 1.0 6.8 4 1 3 7 7 7 1 Up-regulated During Septation Lipoprotein_20 PF13942.6 EMD67939.1 - 0.023 14.6 0.3 0.023 14.6 0.3 6.4 7 2 0 8 8 8 0 YfhG lipoprotein Filo_VP35 PF02097.15 EMD67939.1 - 0.054 12.5 2.8 0.63 9.0 0.3 2.8 2 1 0 2 2 2 0 Filoviridae VP35 Acetyltransf_2 PF00797.17 EMD67940.1 - 9.4e-39 133.6 0.0 1.2e-38 133.3 0.0 1.1 1 0 0 1 1 1 1 N-acetyltransferase Ribosomal_S5 PF00333.20 EMD67940.1 - 1.6 8.7 3.3 6 6.9 0.2 2.2 2 0 0 2 2 2 0 Ribosomal protein S5, N-terminal domain MOZ_SAS PF01853.18 EMD67941.1 - 3.6e-76 254.8 0.0 5.5e-76 254.2 0.0 1.2 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 EMD67941.1 - 8.3e-20 70.2 4.2 4.2e-19 67.9 3.0 2.5 2 0 0 2 2 2 1 MYST family zinc finger domain PHD_4 PF16866.5 EMD67941.1 - 6.4e-09 35.8 7.5 6.4e-09 35.8 7.5 2.2 2 0 0 2 2 2 1 PHD-finger Acetyltransf_7 PF13508.7 EMD67941.1 - 0.0054 17.1 0.0 0.01 16.3 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain PHD PF00628.29 EMD67941.1 - 0.0063 16.4 8.4 0.0063 16.4 8.4 2.3 2 0 0 2 2 2 1 PHD-finger C1_1 PF00130.22 EMD67941.1 - 0.018 14.9 2.3 0.035 14.0 0.3 2.3 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) PHD_2 PF13831.6 EMD67941.1 - 9.9 5.8 6.9 3.3 7.3 2.4 2.4 2 0 0 2 2 2 0 PHD-finger Velvet PF11754.8 EMD67942.1 - 3.7e-40 138.5 0.2 9.9e-30 104.3 0.0 2.1 1 1 1 2 2 2 2 Velvet factor Sporozoite_P67 PF05642.11 EMD67943.1 - 1.5 6.8 14.6 1.5 6.9 14.6 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF1180 PF06679.12 EMD67943.1 - 5.3 7.4 6.0 6.5 7.1 6.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) FAM199X PF15814.5 EMD67943.1 - 5.8 5.9 27.5 6.9 5.6 27.5 1.0 1 0 0 1 1 1 0 Protein family FAM199X Apt1 PF10351.9 EMD67943.1 - 8.1 5.2 12.7 9.2 5.0 12.7 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain Flt3_lig PF02947.14 EMD67944.1 - 0.054 13.7 0.1 0.083 13.1 0.1 1.3 1 0 0 1 1 1 0 flt3 ligand p450 PF00067.22 EMD67945.1 - 3.3e-43 148.1 0.0 4.7e-43 147.6 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 HSP70 PF00012.20 EMD67948.1 - 2.1e-10 39.5 0.0 4.3e-10 38.4 0.0 1.5 2 0 0 2 2 2 1 Hsp70 protein CDC45 PF02724.14 EMD67950.1 - 2.4e-237 789.3 0.0 3e-237 789.0 0.0 1.1 1 0 0 1 1 1 1 CDC45-like protein FAM60A PF15396.6 EMD67950.1 - 0.19 11.7 1.1 0.56 10.2 1.1 1.7 1 0 0 1 1 1 0 Protein Family FAM60A Acyltransferase PF01553.21 EMD67951.1 - 6.7e-11 41.9 0.0 1.1e-09 38.0 0.0 2.3 1 1 0 1 1 1 1 Acyltransferase Glyco_hydro_76 PF03663.14 EMD67952.1 - 1e-126 423.4 14.4 1.2e-126 423.2 14.4 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 EMD67952.1 - 0.024 13.7 11.3 0.22 10.5 1.1 2.8 1 1 0 2 2 2 0 Glycosyl Hydrolase Family 88 Ccdc124 PF06244.12 EMD67953.1 - 1.2e-22 80.8 25.2 1.2e-22 80.8 25.2 2.7 2 1 0 2 2 2 1 Coiled-coil domain-containing protein 124 /Oxs1 TMEM214 PF10151.9 EMD67953.1 - 0.19 10.2 14.2 0.34 9.3 14.2 1.3 1 0 0 1 1 1 0 TMEM214, C-terminal, caspase 4 activator MIP PF00230.20 EMD67954.1 - 5.5e-06 26.3 0.0 5.9e-06 26.2 0.0 1.0 1 0 0 1 1 1 1 Major intrinsic protein HET PF06985.11 EMD67956.1 - 3.3e-22 79.4 0.0 4.9e-22 78.8 0.0 1.2 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) OPT PF03169.15 EMD67957.1 - 2.3e-158 528.7 21.6 2.6e-158 528.4 21.6 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Phage_holin_2_1 PF04971.12 EMD67957.1 - 0.13 12.2 1.9 0.46 10.5 0.0 2.9 2 0 0 2 2 2 0 Bacteriophage P21 holin S MscL PF01741.18 EMD67957.1 - 1.1 9.6 2.9 16 5.8 0.1 3.1 3 0 0 3 3 3 0 Large-conductance mechanosensitive channel, MscL DUF4212 PF13937.6 EMD67957.1 - 9.3 6.7 16.5 2.9 8.3 0.1 4.8 5 0 0 5 5 5 0 Domain of unknown function (DUF4212) Peptidase_C13 PF01650.18 EMD67958.1 - 1.5e-41 142.6 0.1 2e-41 142.2 0.1 1.1 1 0 0 1 1 1 1 Peptidase C13 family PARP PF00644.20 EMD67959.1 - 5.9e-11 42.3 0.2 2.8e-10 40.1 0.0 2.0 2 0 0 2 2 2 1 Poly(ADP-ribose) polymerase catalytic domain UQ_con PF00179.26 EMD67959.1 - 1.7e-05 24.5 0.0 3.8e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme COG7 PF10191.9 EMD67960.1 - 0.00045 18.6 0.0 0.0058 14.9 0.0 2.0 2 0 0 2 2 2 1 Golgi complex component 7 (COG7) COG5 PF10392.9 EMD67960.1 - 0.0034 17.5 0.2 0.0074 16.5 0.2 1.6 1 0 0 1 1 1 1 Golgi transport complex subunit 5 DEDD_Tnp_IS110 PF01548.17 EMD67960.1 - 0.11 12.4 0.3 0.26 11.2 0.3 1.6 1 0 0 1 1 1 0 Transposase ATG16 PF08614.11 EMD67960.1 - 0.15 12.3 3.4 1.2 9.4 0.1 2.5 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) DUF4589 PF15252.6 EMD67960.1 - 0.5 10.3 6.5 0.25 11.3 0.9 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4589) BIR PF00653.21 EMD67961.1 - 2.6e-46 156.1 0.4 9.1e-22 77.5 0.2 2.5 2 0 0 2 2 2 2 Inhibitor of Apoptosis domain CiPC PF15800.5 EMD67961.1 - 0.046 13.4 2.1 0.076 12.7 2.1 1.3 1 0 0 1 1 1 0 Clock interacting protein circadian ORC6 PF05460.13 EMD67961.1 - 0.16 11.2 2.9 0.26 10.5 2.9 1.3 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Tam41_Mmp37 PF09139.11 EMD67962.1 - 2e-120 402.1 0.0 2.3e-120 401.9 0.0 1.0 1 0 0 1 1 1 1 Phosphatidate cytidylyltransferase, mitochondrial DUF2856 PF11043.8 EMD67962.1 - 0.053 13.6 0.1 0.13 12.4 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2856) AT_hook PF02178.19 EMD67963.1 - 0.076 12.9 19.3 0.31 11.1 5.4 4.0 2 0 0 2 2 2 0 AT hook motif GEN1_C PF18380.1 EMD67964.1 - 1e-29 103.5 0.2 1e-29 103.5 0.2 2.4 2 0 0 2 2 2 1 Holliday junction resolvase Gen1 C-terminal domain XPG_I PF00867.18 EMD67964.1 - 3.3e-23 81.8 0.0 6.2e-23 81.0 0.0 1.5 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.17 EMD67964.1 - 1.4e-11 44.7 0.0 3e-11 43.7 0.0 1.5 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I_2 PF12813.7 EMD67964.1 - 0.0093 15.5 0.0 0.017 14.6 0.0 1.3 1 0 0 1 1 1 1 XPG domain containing GRAB PF10375.9 EMD67965.1 - 0.2 11.6 0.0 0.32 10.9 0.0 1.3 1 0 0 1 1 1 0 GRIP-related Arf-binding domain Thg1 PF04446.12 EMD67966.1 - 9.1e-37 125.9 0.0 1.4e-36 125.3 0.0 1.3 1 0 0 1 1 1 1 tRNAHis guanylyltransferase SurE PF01975.17 EMD67967.1 - 2.4e-28 99.3 0.5 3e-28 98.9 0.5 1.1 1 0 0 1 1 1 1 Survival protein SurE DUF3328 PF11807.8 EMD67968.1 - 0.0018 18.1 2.8 0.16 11.7 0.0 2.5 2 1 1 3 3 3 2 Domain of unknown function (DUF3328) MFS_1 PF07690.16 EMD67968.1 - 0.028 13.4 10.7 0.038 12.9 10.7 1.2 1 0 0 1 1 1 0 Major Facilitator Superfamily DUF2569 PF10754.9 EMD67968.1 - 0.089 13.2 6.3 0.036 14.5 3.6 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2569) Shisa PF13908.6 EMD67968.1 - 0.09 13.0 1.9 2 8.6 0.0 2.5 2 1 1 3 3 3 0 Wnt and FGF inhibitory regulator CcmD PF04995.14 EMD67968.1 - 0.1 12.7 0.1 0.1 12.7 0.1 2.7 3 0 0 3 3 3 0 Heme exporter protein D (CcmD) MARVEL PF01284.23 EMD67968.1 - 0.96 9.5 14.3 3.9 7.5 14.2 1.8 1 1 1 2 2 2 0 Membrane-associating domain OAD_gamma PF04277.13 EMD67968.1 - 1.4 9.6 0.0 1.4 9.6 0.0 3.1 2 1 1 3 3 3 0 Oxaloacetate decarboxylase, gamma chain TssN PF17555.2 EMD67968.1 - 1.5 8.1 8.6 2.1 7.7 8.6 1.1 1 0 0 1 1 1 0 Type VI secretion system, TssN DUF2254 PF10011.9 EMD67968.1 - 7.1 5.3 6.0 4.7 5.9 3.0 1.8 2 0 0 2 2 2 0 Predicted membrane protein (DUF2254) Peptidase_C1_2 PF03051.15 EMD67969.1 - 4.5e-156 520.0 0.1 5.5e-156 519.7 0.1 1.1 1 0 0 1 1 1 1 Peptidase C1-like family Peptidase_C1 PF00112.23 EMD67969.1 - 5e-07 30.0 0.1 0.0039 17.3 0.1 2.4 2 0 0 2 2 2 2 Papain family cysteine protease Herpes_capsid PF06112.11 EMD67969.1 - 0.16 12.0 0.1 0.3 11.2 0.1 1.5 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein Thiolase_N PF00108.23 EMD67970.1 - 1e-88 297.1 0.8 1.3e-88 296.7 0.8 1.1 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EMD67970.1 - 2e-36 124.3 0.8 2e-36 124.3 0.8 2.2 2 1 1 3 3 3 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 EMD67970.1 - 3.8e-05 23.4 5.1 0.00064 19.4 0.6 3.1 2 1 1 3 3 3 2 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.10 EMD67970.1 - 0.026 14.4 1.8 0.84 9.5 0.1 2.8 3 0 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Homeobox_KN PF05920.11 EMD67971.1 - 2.5e-17 62.5 0.0 7.4e-17 61.0 0.0 1.9 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 EMD67971.1 - 5.1e-05 23.0 0.1 0.00014 21.7 0.1 1.7 1 0 0 1 1 1 1 Homeodomain zf-C2H2_4 PF13894.6 EMD67971.1 - 0.00091 19.9 2.4 0.00091 19.9 2.4 6.2 7 0 0 7 7 7 1 C2H2-type zinc finger zf-C2H2_2 PF12756.7 EMD67971.1 - 0.028 14.8 10.9 0.95 9.8 6.3 3.7 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) HTH_Tnp_Tc5 PF03221.16 EMD67971.1 - 0.047 13.7 0.0 0.11 12.5 0.0 1.6 1 0 0 1 1 1 0 Tc5 transposase DNA-binding domain PyrI_C PF02748.15 EMD67971.1 - 1.6 8.7 6.7 23 5.0 0.1 4.1 4 0 0 4 4 4 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_3rep PF18868.1 EMD67971.1 - 4.3 8.0 8.4 8.9 7.0 0.0 2.7 3 0 0 3 3 3 0 Zinc finger C2H2-type, 3 repeats zf-C2H2_jaz PF12171.8 EMD67973.1 - 7.9e-08 32.4 0.5 1.4e-07 31.6 0.5 1.4 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EMD67973.1 - 2.8e-06 27.5 0.5 5.2e-06 26.7 0.5 1.4 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 EMD67973.1 - 0.12 12.7 0.0 0.25 11.7 0.0 1.6 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.26 EMD67973.1 - 0.23 12.0 0.2 0.54 10.8 0.2 1.6 1 0 0 1 1 1 0 Zinc finger, C2H2 type Fzo_mitofusin PF04799.13 EMD67973.1 - 3.7 7.1 9.3 0.056 13.0 1.8 1.7 2 0 0 2 2 2 0 fzo-like conserved region GST_N_3 PF13417.6 EMD67974.1 - 2e-17 63.3 0.1 6.5e-17 61.7 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EMD67974.1 - 4.6e-15 55.7 0.0 9e-15 54.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 EMD67974.1 - 1.8e-14 53.8 0.0 4e-14 52.7 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Glutaredoxin PF00462.24 EMD67974.1 - 3.6e-07 30.3 0.0 1.1e-06 28.8 0.0 1.8 2 0 0 2 2 2 1 Glutaredoxin GST_C_2 PF13410.6 EMD67974.1 - 0.00013 21.9 0.0 0.00024 21.1 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EMD67974.1 - 0.0044 17.2 0.1 0.0072 16.5 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EMD67974.1 - 0.016 15.4 0.1 0.026 14.7 0.1 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C_5 PF16865.5 EMD67974.1 - 0.16 12.5 0.0 0.24 12.0 0.0 1.3 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain DUF2946 PF11162.8 EMD67975.1 - 0.088 13.5 0.6 0.088 13.5 0.6 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2946) DNA_topoisoIV PF00521.20 EMD67976.1 - 1.3e-125 419.6 0.1 3.4e-125 418.3 0.1 1.7 1 0 0 1 1 1 1 DNA gyrase/topoisomerase IV, subunit A TOPRIM_C PF16898.5 EMD67976.1 - 2.6e-49 166.7 2.2 2.6e-49 166.7 2.2 2.1 2 0 0 2 2 2 1 C-terminal associated domain of TOPRIM DNA_gyraseB PF00204.25 EMD67976.1 - 1.5e-26 92.9 4.6 3.4e-26 91.8 4.6 1.6 1 0 0 1 1 1 1 DNA gyrase B HATPase_c PF02518.26 EMD67976.1 - 2.3e-14 53.8 0.1 5.7e-14 52.6 0.1 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim PF01751.22 EMD67976.1 - 7.7e-07 29.3 0.0 4e-06 27.0 0.0 2.3 1 0 0 1 1 1 1 Toprim domain DUF927 PF06048.11 EMD67976.1 - 0.026 14.1 0.1 0.05 13.2 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF927) STPPase_N PF16891.5 EMD67976.1 - 0.23 11.9 2.5 8 7.0 0.1 3.0 3 0 0 3 3 3 0 Serine-threonine protein phosphatase N-terminal domain Ntox17 PF15524.6 EMD67976.1 - 0.67 10.3 3.4 1.7 9.0 0.3 3.1 3 0 0 3 3 3 0 Novel toxin 17 Aminotran_1_2 PF00155.21 EMD67979.1 - 7.7e-62 209.5 0.0 9.2e-62 209.3 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Alliinase_C PF04864.13 EMD67979.1 - 0.00052 19.0 0.0 0.00078 18.4 0.0 1.2 1 0 0 1 1 1 1 Allinase Cys_Met_Meta_PP PF01053.20 EMD67979.1 - 0.011 14.2 0.0 0.023 13.2 0.0 1.4 2 0 0 2 2 2 0 Cys/Met metabolism PLP-dependent enzyme DUF4911 PF16256.5 EMD67979.1 - 0.12 12.3 0.2 4.3 7.4 0.0 3.3 4 0 0 4 4 4 0 Domain of unknown function (DUF4911) YuzL PF14115.6 EMD67980.1 - 0.11 13.0 0.1 0.26 11.8 0.1 1.6 1 0 0 1 1 1 0 YuzL-like protein Ivy PF08816.11 EMD67980.1 - 0.15 12.3 0.0 2.6 8.3 0.0 2.1 2 0 0 2 2 2 0 Inhibitor of vertebrate lysozyme (Ivy) HSP70 PF00012.20 EMD67981.1 - 3.8e-260 864.2 7.3 4.3e-260 864.0 7.3 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EMD67981.1 - 7.2e-17 61.2 0.0 1.1e-15 57.3 0.0 2.1 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.16 EMD67981.1 - 0.0034 17.1 0.0 0.011 15.4 0.0 1.9 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain Hydantoinase_A PF01968.18 EMD67981.1 - 0.015 14.6 0.1 0.036 13.3 0.1 1.7 1 0 0 1 1 1 0 Hydantoinase/oxoprolinase FtsA PF14450.6 EMD67981.1 - 0.04 14.3 4.2 8.2 6.9 0.3 3.5 3 2 0 3 3 3 0 Cell division protein FtsA Sds3 PF08598.11 EMD67982.1 - 2.8e-46 158.3 1.7 5e-45 154.2 1.7 2.1 1 1 0 1 1 1 1 Sds3-like DUF3245 PF11595.8 EMD67982.1 - 0.69 10.4 5.9 3.2 8.2 5.9 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF3245) DUF3128 PF11326.8 EMD67983.1 - 7.2e-25 87.2 4.0 1.1e-24 86.6 4.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3128) VPS13_mid_rpt PF16910.5 EMD67984.1 - 5.8e-99 330.3 16.2 7.6e-96 320.1 1.7 5.1 3 1 0 3 3 3 2 Repeating coiled region of VPS13 SHR-BD PF06650.12 EMD67984.1 - 2e-94 316.0 0.0 1.6e-93 313.0 0.0 2.4 3 0 0 3 3 3 1 SHR-binding domain of vacuolar-sorting associated protein 13 VPS13 PF16908.5 EMD67984.1 - 3e-85 285.8 6.9 2.2e-82 276.4 0.0 4.2 5 0 0 5 5 5 2 Vacuolar sorting-associated protein 13, N-terminal VPS13_C PF16909.5 EMD67984.1 - 8.3e-73 243.9 4.6 3.7e-69 232.1 0.5 2.7 2 0 0 2 2 2 2 Vacuolar-sorting-associated 13 protein C-terminal Chorein_N PF12624.7 EMD67984.1 - 2.3e-40 137.3 0.0 1e-39 135.3 0.0 2.3 1 0 0 1 1 1 1 N-terminal region of Chorein or VPS13 ATG_C PF09333.11 EMD67984.1 - 3.8e-05 24.0 0.0 0.00017 21.9 0.0 2.2 1 0 0 1 1 1 1 Autophagy-related protein C terminal domain DUF3429 PF11911.8 EMD67985.1 - 3.6e-44 150.6 13.4 5.2e-44 150.0 13.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3429) Rhomboid PF01694.22 EMD67986.1 - 0.00047 20.2 4.1 0.00091 19.3 4.1 1.5 1 0 0 1 1 1 1 Rhomboid family DUF1751 PF08551.10 EMD67986.1 - 0.064 13.8 3.4 0.07 13.7 1.7 2.0 1 1 0 1 1 1 0 Eukaryotic integral membrane protein (DUF1751) HrpB7 PF09486.10 EMD67987.1 - 0.0076 16.6 8.6 0.0076 16.6 8.6 2.2 2 1 1 3 3 2 1 Bacterial type III secretion protein (HrpB7) DUF4795 PF16043.5 EMD67987.1 - 0.02 14.5 13.3 0.049 13.2 13.2 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) UPF0242 PF06785.11 EMD67987.1 - 0.025 14.7 16.8 0.046 13.8 16.3 1.6 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Tweety PF04906.13 EMD67987.1 - 0.033 12.9 2.1 0.053 12.2 2.1 1.3 1 0 0 1 1 1 0 Tweety GAS PF13851.6 EMD67987.1 - 0.034 13.5 21.9 0.017 14.5 13.5 2.4 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding DivIC PF04977.15 EMD67987.1 - 0.045 13.5 14.4 0.21 11.4 1.9 3.5 3 0 0 3 3 3 0 Septum formation initiator Cnn_1N PF07989.11 EMD67987.1 - 0.076 13.2 20.4 0.11 12.6 11.8 3.4 2 2 0 2 2 2 0 Centrosomin N-terminal motif 1 Fib_alpha PF08702.10 EMD67987.1 - 0.18 12.0 11.9 0.094 12.9 6.4 2.4 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DUF4164 PF13747.6 EMD67987.1 - 0.19 12.0 26.9 0.15 12.4 2.8 4.0 2 1 2 4 4 4 0 Domain of unknown function (DUF4164) Snapin_Pallidin PF14712.6 EMD67987.1 - 0.2 12.1 9.6 3.1 8.3 1.1 3.3 2 1 1 3 3 3 0 Snapin/Pallidin HALZ PF02183.18 EMD67987.1 - 0.21 11.9 14.9 6.3 7.1 0.5 3.6 3 0 0 3 3 3 0 Homeobox associated leucine zipper Spc7 PF08317.11 EMD67987.1 - 0.35 9.7 22.0 1.2 7.9 22.0 1.9 1 1 0 1 1 1 0 Spc7 kinetochore protein FUSC PF04632.12 EMD67987.1 - 0.38 9.2 5.5 0.75 8.3 5.5 1.4 1 0 0 1 1 1 0 Fusaric acid resistance protein family PTPA PF03095.15 EMD67987.1 - 0.43 10.0 1.6 0.68 9.3 1.6 1.3 1 0 0 1 1 1 0 Phosphotyrosyl phosphate activator (PTPA) protein DUF3450 PF11932.8 EMD67987.1 - 0.46 9.8 16.8 0.049 12.9 4.2 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF3450) Baculo_PEP_C PF04513.12 EMD67987.1 - 0.68 10.0 2.1 1.2 9.1 0.7 2.0 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus ZapB PF06005.12 EMD67987.1 - 0.69 10.4 22.9 2.4 8.7 0.8 3.7 2 1 1 3 3 3 0 Cell division protein ZapB bZIP_1 PF00170.21 EMD67987.1 - 0.76 9.9 18.1 1 9.5 5.6 4.1 3 1 0 3 3 3 0 bZIP transcription factor FAM76 PF16046.5 EMD67987.1 - 1.3 8.3 12.1 2.2 7.6 12.1 1.3 1 0 0 1 1 1 0 FAM76 protein Phage_GPO PF05929.11 EMD67987.1 - 1.6 8.3 10.5 3.1 7.3 8.6 1.9 1 1 1 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase FapA PF03961.13 EMD67987.1 - 2.1 6.8 18.7 1.3 7.5 5.3 2.1 1 1 1 2 2 2 0 Flagellar Assembly Protein A DUF3287 PF11690.8 EMD67987.1 - 2.3 7.9 6.3 6.8 6.4 0.1 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF3287) IZUMO PF15005.6 EMD67987.1 - 2.5 8.6 5.6 4 8.0 4.7 1.8 1 1 0 1 1 1 0 Izumo sperm-egg fusion, Ig domain-associated Spc24 PF08286.11 EMD67987.1 - 2.8 8.2 18.9 4 7.7 0.2 3.4 2 1 1 3 3 3 0 Spc24 subunit of Ndc80 KLRAQ PF10205.9 EMD67987.1 - 3 8.1 13.6 0.93 9.8 4.7 3.1 1 1 2 3 3 3 0 Predicted coiled-coil domain-containing protein DUF1664 PF07889.12 EMD67987.1 - 3.3 7.8 11.0 3.1 7.9 3.9 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) ERM PF00769.19 EMD67987.1 - 6.3 6.5 24.3 2.1 8.1 20.4 2.1 1 1 1 2 2 2 0 Ezrin/radixin/moesin family Ax_dynein_light PF10211.9 EMD67987.1 - 7 6.6 24.1 1.2 9.0 4.7 3.3 1 1 2 3 3 3 0 Axonemal dynein light chain Laminin_II PF06009.12 EMD67987.1 - 7.1 6.7 14.3 53 3.8 8.4 2.6 1 1 1 2 2 2 0 Laminin Domain II TMF_TATA_bd PF12325.8 EMD67987.1 - 7.7 6.8 26.6 0.75 10.0 10.3 3.1 2 1 1 3 3 2 0 TATA element modulatory factor 1 TATA binding adh_short PF00106.25 EMD67988.1 - 2.5e-08 33.6 0.0 0.012 15.1 0.0 3.2 2 1 0 3 3 3 3 short chain dehydrogenase adh_short_C2 PF13561.6 EMD67988.1 - 0.099 12.2 0.0 1.3 8.5 0.0 2.1 2 0 0 2 2 2 0 Enoyl-(Acyl carrier protein) reductase FGGY_C PF02782.16 EMD67991.1 - 3.7e-73 245.5 1.1 5.3e-73 245.0 1.1 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 EMD67991.1 - 1.8e-62 211.1 0.0 2.5e-62 210.6 0.0 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain WYL PF13280.6 EMD67992.1 - 0.1 12.7 0.0 0.15 12.1 0.0 1.3 1 0 0 1 1 1 0 WYL domain DUF3328 PF11807.8 EMD67993.1 - 4.1e-36 124.8 1.3 4.9e-36 124.6 1.3 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) WD40 PF00400.32 EMD67995.1 - 2.7e-39 132.4 19.5 9.1e-05 23.2 0.0 7.8 7 0 0 7 7 7 7 WD domain, G-beta repeat F-box-like PF12937.7 EMD67995.1 - 7e-10 38.6 0.1 1.3e-09 37.8 0.1 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EMD67995.1 - 3.3e-08 33.2 0.1 6.3e-08 32.3 0.1 1.5 1 0 0 1 1 1 1 F-box domain ANAPC4_WD40 PF12894.7 EMD67995.1 - 4.4e-07 30.1 1.4 0.69 10.3 0.0 5.2 2 2 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EMD67995.1 - 0.00068 18.4 1.8 12 4.4 0.0 5.0 5 1 1 6 6 6 1 Nucleoporin Nup120/160 PQQ_2 PF13360.6 EMD67995.1 - 0.0051 16.4 1.7 1.3 8.6 1.0 3.0 1 1 1 2 2 2 1 PQQ-like domain F-box_4 PF15966.5 EMD67995.1 - 0.06 13.2 0.0 0.16 11.8 0.0 1.7 1 0 0 1 1 1 0 F-box BRAP2 PF07576.12 EMD67996.1 - 1.1e-34 118.6 0.1 2.1e-34 117.7 0.1 1.3 1 0 0 1 1 1 1 BRCA1-associated protein 2 zf-UBP PF02148.19 EMD67996.1 - 8.9e-20 70.8 5.3 2.6e-19 69.3 5.3 1.8 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein zf-RING_2 PF13639.6 EMD67996.1 - 2.9e-08 33.9 8.8 2.9e-08 33.9 8.8 2.4 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 EMD67996.1 - 6.4e-06 25.9 8.2 6.4e-06 25.9 8.2 1.8 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMD67996.1 - 6.2e-05 22.8 7.3 6.2e-05 22.8 7.3 1.9 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EMD67996.1 - 0.00011 22.2 4.7 0.00043 20.2 4.3 2.2 1 1 1 2 2 2 1 RING-type zinc-finger zf-rbx1 PF12678.7 EMD67996.1 - 0.00018 21.8 6.0 0.00054 20.2 6.0 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_11 PF17123.5 EMD67996.1 - 0.00037 20.2 4.9 0.00037 20.2 4.9 2.6 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_3 PF13920.6 EMD67996.1 - 0.00073 19.3 15.6 0.00088 19.1 5.9 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.6 EMD67996.1 - 0.0023 17.8 2.8 0.0065 16.3 2.8 1.8 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_5 PF14634.6 EMD67996.1 - 0.0027 17.7 6.5 0.0027 17.7 6.5 2.2 2 0 0 2 2 2 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 EMD67996.1 - 0.0086 16.1 3.9 0.023 14.8 3.9 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Urease_gamma PF00547.18 EMD67996.1 - 0.11 12.9 0.7 0.24 11.7 0.7 1.6 1 0 0 1 1 1 0 Urease, gamma subunit AAA_23 PF13476.6 EMD67996.1 - 0.23 12.0 6.5 0.36 11.3 6.5 1.3 1 0 0 1 1 1 0 AAA domain Prok-RING_4 PF14447.6 EMD67996.1 - 0.84 9.6 18.3 0.2 11.5 8.6 3.2 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 Tropomyosin_1 PF12718.7 EMD67996.1 - 1.1 9.4 21.6 2.7 8.1 21.6 1.6 1 0 0 1 1 1 0 Tropomyosin like Tropomyosin PF00261.20 EMD67996.1 - 1.5 8.1 23.9 10 5.4 23.9 1.9 1 1 0 1 1 1 0 Tropomyosin Zn_ribbon_17 PF17120.5 EMD67996.1 - 1.6 8.4 13.4 0.09 12.4 5.4 2.5 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type Exonuc_VII_L PF02601.15 EMD67996.1 - 1.9 8.0 9.6 3 7.3 9.6 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Fib_alpha PF08702.10 EMD67996.1 - 2.7 8.2 12.6 2.8 8.1 10.7 1.9 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family FUSC PF04632.12 EMD67996.1 - 2.9 6.3 11.9 4.4 5.7 11.9 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family Jnk-SapK_ap_N PF09744.9 EMD67996.1 - 3 8.1 22.1 9.6 6.4 20.7 2.1 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 LMBR1 PF04791.16 EMD67996.1 - 5.2 5.9 6.4 7.2 5.4 6.4 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein TMF_TATA_bd PF12325.8 EMD67996.1 - 6.2 7.1 17.4 0.46 10.7 3.6 2.6 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding ZapB PF06005.12 EMD67996.1 - 6.2 7.3 22.6 0.26 11.8 7.5 2.8 2 1 1 3 3 2 0 Cell division protein ZapB Med26_C PF15693.5 EMD67996.1 - 7.4 6.7 6.9 14 5.7 6.9 1.5 1 0 0 1 1 1 0 Mediator complex subunit 26 C-terminal Drf_GBD PF06371.13 EMD67998.1 - 3.1e-19 69.3 1.0 1.2e-09 38.0 0.1 2.3 2 0 0 2 2 2 2 Diaphanous GTPase-binding Domain Mannosyl_trans2 PF04188.13 EMD68000.1 - 4.1e-61 207.6 12.6 6e-61 207.1 12.6 1.2 1 0 0 1 1 1 1 Mannosyltransferase (PIG-V) Ribosomal_L7Ae PF01248.26 EMD68001.1 - 2.3e-22 78.6 0.9 3.9e-22 77.8 0.9 1.4 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family OCD_Mu_crystall PF02423.15 EMD68002.1 - 3.5e-07 29.5 0.1 0.00011 21.2 0.0 3.4 4 1 0 4 4 4 2 Ornithine cyclodeaminase/mu-crystallin family Shikimate_DH PF01488.20 EMD68002.1 - 0.012 15.7 0.0 0.094 12.8 0.0 2.4 3 0 0 3 3 3 0 Shikimate / quinate 5-dehydrogenase BLM10_mid PF16507.5 EMD68003.1 - 7.1e-208 691.5 0.0 1e-206 687.7 0.0 2.3 3 0 0 3 3 3 1 Proteasome-substrate-size regulator, mid region DUF3437 PF11919.8 EMD68003.1 - 1.6e-30 104.9 0.2 1.7e-29 101.5 0.0 3.0 4 0 0 4 4 4 1 Domain of unknown function (DUF3437) BLM10_N PF16547.5 EMD68003.1 - 2.9e-22 78.8 0.0 8.7e-22 77.2 0.0 1.9 1 0 0 1 1 1 1 Proteasome-substrate-size regulator, N-terminal HEAT PF02985.22 EMD68003.1 - 0.012 15.8 0.1 5.9 7.4 0.0 4.4 4 0 0 4 4 4 0 HEAT repeat IFRD PF05004.13 EMD68003.1 - 0.025 13.7 0.0 0.82 8.7 0.0 2.7 2 0 0 2 2 2 0 Interferon-related developmental regulator (IFRD) HEAT_EZ PF13513.6 EMD68003.1 - 0.2 12.2 6.4 4.3 7.9 0.0 4.9 5 0 0 5 5 5 0 HEAT-like repeat SKA2 PF16740.5 EMD68004.1 - 0.066 13.0 0.2 2.8 7.7 0.0 2.6 2 1 1 3 3 3 0 Spindle and kinetochore-associated protein 2 Prenyltransf PF01255.19 EMD68005.1 - 2.2e-82 276.0 1.5 3.8e-82 275.2 1.5 1.4 1 1 0 1 1 1 1 Putative undecaprenyl diphosphate synthase Vault_2 PF17794.1 EMD68006.1 - 0.13 12.6 0.0 0.35 11.3 0.0 1.7 1 0 0 1 1 1 0 Major Vault Protein repeat domain Peptidase_S10 PF00450.22 EMD68007.1 - 1.5e-66 225.6 0.0 3e-66 224.6 0.0 1.4 1 1 0 1 1 1 1 Serine carboxypeptidase WD40 PF00400.32 EMD68008.1 - 2.9e-88 287.4 11.1 6.6e-12 45.8 0.0 13.0 12 0 0 12 12 12 12 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD68008.1 - 9.6e-50 166.9 0.3 1.1e-05 25.6 0.0 11.7 3 1 8 11 11 11 9 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EMD68008.1 - 8e-27 94.1 4.1 0.004 16.2 0.0 11.9 3 3 9 12 12 12 9 WD40 region of Ge1, enhancer of mRNA-decapping protein NACHT PF05729.12 EMD68008.1 - 5.3e-24 85.0 0.3 1.2e-23 83.9 0.3 1.7 1 0 0 1 1 1 1 NACHT domain HET PF06985.11 EMD68008.1 - 2.4e-11 44.2 7.9 9.6e-08 32.5 7.7 3.1 2 1 0 2 2 1 1 Heterokaryon incompatibility protein (HET) Nup160 PF11715.8 EMD68008.1 - 2.7e-11 42.8 13.1 0.25 9.9 0.0 8.5 4 2 5 9 9 9 5 Nucleoporin Nup120/160 eIF2A PF08662.11 EMD68008.1 - 6.7e-10 39.2 0.0 0.018 14.9 0.0 6.0 2 2 5 7 7 7 3 Eukaryotic translation initiation factor eIF2A Nbas_N PF15492.6 EMD68008.1 - 4.8e-09 35.9 5.1 1.3 8.3 0.0 7.7 2 2 4 8 8 8 3 Neuroblastoma-amplified sequence, N terminal PD40 PF07676.12 EMD68008.1 - 3.3e-08 33.2 11.5 0.38 10.7 0.0 8.8 10 0 0 10 10 9 1 WD40-like Beta Propeller Repeat Proteasome_A_N PF10584.9 EMD68008.1 - 0.00024 20.7 7.9 13 5.6 0.2 7.9 8 0 0 8 8 8 0 Proteasome subunit A N-terminal signature Nucleoporin_N PF08801.11 EMD68008.1 - 0.00049 19.0 0.2 10 4.8 0.0 5.1 3 2 1 6 6 6 1 Nup133 N terminal like Cytochrom_D1 PF02239.16 EMD68008.1 - 0.0019 16.8 0.5 4.3 5.8 0.0 4.6 4 1 0 5 5 5 1 Cytochrome D1 heme domain WD40_like PF17005.5 EMD68008.1 - 0.0032 16.9 0.0 4.3 6.6 0.0 4.2 4 1 0 4 4 4 1 WD40-like domain AAA_16 PF13191.6 EMD68008.1 - 0.013 15.9 0.4 0.033 14.6 0.4 1.7 1 0 0 1 1 1 0 AAA ATPase domain Plus-3 PF03126.18 EMD68009.1 - 2.2e-22 79.6 0.0 5.2e-22 78.4 0.0 1.7 1 0 0 1 1 1 1 Plus-3 domain DDHD PF02862.17 EMD68009.1 - 5 7.2 13.0 17 5.5 7.7 2.3 2 0 0 2 2 2 0 DDHD domain COQ7 PF03232.13 EMD68010.1 - 3.6e-68 228.7 0.2 4.3e-68 228.4 0.2 1.1 1 0 0 1 1 1 1 Ubiquinone biosynthesis protein COQ7 Rubrerythrin PF02915.17 EMD68010.1 - 0.00024 21.5 0.0 0.00042 20.7 0.0 1.4 1 0 0 1 1 1 1 Rubrerythrin DUF4455 PF14643.6 EMD68010.1 - 0.079 11.6 0.2 0.11 11.1 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4455) Lipase_GDSL PF00657.22 EMD68011.1 - 1e-06 28.9 0.0 1.3e-06 28.6 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.6 EMD68011.1 - 0.00022 21.7 6.1 0.00056 20.3 6.1 1.7 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Oxysterol_BP PF01237.18 EMD68012.1 - 2e-114 382.3 0.0 6.7e-114 380.6 0.0 1.9 2 0 0 2 2 2 1 Oxysterol-binding protein PH_8 PF15409.6 EMD68012.1 - 3.1e-39 133.1 0.1 8.1e-39 131.8 0.1 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 EMD68012.1 - 3e-05 24.5 0.5 9.3e-05 22.9 0.0 2.0 2 0 0 2 2 2 1 PH domain PH_11 PF15413.6 EMD68012.1 - 0.19 12.1 1.3 5.1 7.6 0.3 3.1 2 1 0 2 2 2 0 Pleckstrin homology domain Mucin PF01456.17 EMD68012.1 - 6.3 6.8 13.1 14 5.7 5.7 2.7 2 0 0 2 2 2 0 Mucin-like glycoprotein TPR_12 PF13424.6 EMD68013.1 - 1.2e-11 44.7 18.5 0.019 15.3 0.3 8.6 9 0 0 9 9 9 3 Tetratricopeptide repeat AAA_16 PF13191.6 EMD68013.1 - 5.1e-08 33.5 0.0 3.4e-07 30.8 0.0 2.6 2 0 0 2 2 1 1 AAA ATPase domain NACHT PF05729.12 EMD68013.1 - 9e-08 32.2 0.1 9e-07 29.0 0.0 2.8 2 1 0 2 2 2 1 NACHT domain AAA_22 PF13401.6 EMD68013.1 - 1e-05 25.8 2.6 3.2e-05 24.2 0.0 3.3 3 1 0 3 3 3 1 AAA domain AAA PF00004.29 EMD68013.1 - 0.00019 21.9 0.1 0.0042 17.5 0.0 3.5 3 1 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) PRK PF00485.18 EMD68013.1 - 0.0072 16.1 0.0 0.12 12.1 0.0 2.7 2 0 0 2 2 2 1 Phosphoribulokinase / Uridine kinase family AAA_29 PF13555.6 EMD68013.1 - 0.014 15.2 0.0 0.047 13.4 0.0 1.9 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_33 PF13671.6 EMD68013.1 - 0.022 14.9 0.3 0.74 10.0 0.0 3.1 2 0 0 2 2 2 0 AAA domain TPR_7 PF13176.6 EMD68013.1 - 0.023 14.7 16.5 6.6 7.0 0.0 8.1 8 0 0 8 8 8 0 Tetratricopeptide repeat TsaE PF02367.17 EMD68013.1 - 0.065 13.2 0.2 1 9.4 0.0 2.9 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NTPase_1 PF03266.15 EMD68013.1 - 0.095 12.6 0.0 0.3 11.0 0.0 1.9 1 0 0 1 1 1 0 NTPase TPR_10 PF13374.6 EMD68013.1 - 0.44 10.5 6.4 24 5.0 0.0 5.8 6 0 0 6 6 6 0 Tetratricopeptide repeat ABC_tran PF00005.27 EMD68013.1 - 0.58 10.7 0.0 0.58 10.7 0.0 2.8 3 0 0 3 3 3 0 ABC transporter DUF87 PF01935.17 EMD68013.1 - 0.69 10.0 0.0 0.69 10.0 0.0 5.5 6 2 0 6 6 6 0 Helicase HerA, central domain Aldolase_II PF00596.21 EMD68015.1 - 4.5e-49 166.9 0.1 5.8e-49 166.5 0.1 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain His_Phos_1 PF00300.22 EMD68017.1 - 7.2e-07 29.1 0.7 0.077 12.7 0.0 3.3 2 1 1 3 3 3 2 Histidine phosphatase superfamily (branch 1) DUF883 PF05957.13 EMD68018.1 - 0.092 13.4 0.1 12 6.5 0.1 2.2 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) Vps36_ESCRT-II PF11605.8 EMD68018.1 - 0.11 12.6 0.0 0.21 11.8 0.0 1.4 1 0 0 1 1 1 0 Vacuolar protein sorting protein 36 Vps36 GRAM PF02893.20 EMD68018.1 - 0.15 11.9 0.0 0.25 11.2 0.0 1.3 1 0 0 1 1 1 0 GRAM domain Thiolase_N PF00108.23 EMD68019.1 - 2.8e-73 246.5 5.3 5.2e-73 245.6 5.3 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EMD68019.1 - 1.2e-44 150.9 0.5 2.4e-44 149.9 0.5 1.5 1 0 0 1 1 1 1 Thiolase, C-terminal domain ACP_syn_III PF08545.10 EMD68019.1 - 0.034 14.0 0.5 12 5.8 0.1 2.7 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III ketoacyl-synt PF00109.26 EMD68019.1 - 0.047 13.3 3.4 0.59 9.7 1.5 3.0 2 1 1 3 3 3 0 Beta-ketoacyl synthase, N-terminal domain DUF4129 PF13559.6 EMD68020.1 - 0.07 13.4 0.1 0.18 12.1 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4129) RuvC_III PF18541.1 EMD68020.1 - 0.12 12.3 0.4 0.19 11.6 0.4 1.3 1 0 0 1 1 1 0 RuvC endonuclease subdomain 3 Glyco_hydro_47 PF01532.20 EMD68021.1 - 7.3e-81 272.4 0.4 8.2e-81 272.2 0.4 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Glyco_hydro_127 PF07944.12 EMD68021.1 - 0.0087 14.6 0.0 2 6.8 0.0 2.3 2 1 0 2 2 2 2 Beta-L-arabinofuranosidase, GH127 TBP PF00352.21 EMD68022.1 - 2.2e-66 219.8 0.1 6.3e-32 109.4 0.1 2.2 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.8 EMD68022.1 - 0.00014 21.9 0.0 0.3 11.2 0.0 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF3378) DUF4295 PF14128.6 EMD68022.1 - 0.17 11.8 0.1 0.76 9.6 0.0 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4295) zf-RING_2 PF13639.6 EMD68024.1 - 6e-10 39.3 16.1 7.8e-10 38.9 4.6 3.2 3 0 0 3 3 3 1 Ring finger domain zf-rbx1 PF12678.7 EMD68024.1 - 1.6e-09 37.9 1.8 1.6e-09 37.9 1.8 2.4 2 1 0 2 2 2 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 EMD68024.1 - 8.2e-09 35.2 4.7 8.2e-09 35.2 4.7 2.7 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EMD68024.1 - 2.3e-08 33.7 10.6 5e-08 32.7 1.3 2.5 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 EMD68024.1 - 1.1e-07 31.5 3.1 1.1e-07 31.5 3.1 2.8 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EMD68024.1 - 3.5e-06 26.9 6.1 3.5e-06 26.9 6.1 2.8 1 1 2 3 3 3 1 zinc-RING finger domain zf-C3HC4 PF00097.25 EMD68024.1 - 5.9e-06 26.1 19.0 0.00027 20.8 18.1 2.9 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EMD68024.1 - 1.5e-05 24.9 1.9 1.5e-05 24.9 1.9 2.7 2 2 0 2 2 2 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 EMD68024.1 - 0.00015 21.7 1.0 0.00015 21.7 1.0 2.2 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.6 EMD68024.1 - 0.00028 20.6 2.9 0.00028 20.6 2.9 2.9 2 1 0 2 2 2 1 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.6 EMD68024.1 - 0.00047 20.2 3.2 0.00047 20.2 3.2 2.6 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_11 PF17123.5 EMD68024.1 - 0.16 11.8 7.3 0.32 10.8 0.2 3.2 2 1 1 3 3 3 0 RING-like zinc finger zinc-ribbons_6 PF07191.12 EMD68024.1 - 2.8 8.0 9.9 0.51 10.3 1.6 2.3 2 0 0 2 2 2 0 zinc-ribbons Prim_Zn_Ribbon PF08273.12 EMD68024.1 - 4.5 7.6 7.8 20 5.6 0.2 3.4 3 0 0 3 3 3 0 Zinc-binding domain of primase-helicase IBR PF01485.21 EMD68024.1 - 7.4 6.9 17.2 64 3.9 17.3 2.4 1 1 0 1 1 1 0 IBR domain, a half RING-finger domain zf-RING_2 PF13639.6 EMD68025.1 - 2.4e-05 24.6 8.7 7.3e-05 23.0 8.7 1.8 1 1 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 EMD68025.1 - 0.00021 21.1 5.3 0.00043 20.1 5.3 1.5 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 EMD68025.1 - 0.00071 19.8 5.4 0.0026 18.0 6.1 1.6 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 EMD68025.1 - 0.0028 17.4 3.4 0.0028 17.4 3.4 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 EMD68025.1 - 0.045 13.4 2.2 0.58 9.8 0.8 2.3 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type zf-C3HC4_3 PF13920.6 EMD68025.1 - 0.054 13.4 5.5 0.084 12.7 2.0 2.1 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EMD68025.1 - 0.16 12.0 7.0 0.43 10.7 5.0 2.2 1 1 1 2 2 2 0 RING-type zinc-finger zf-C3HC4 PF00097.25 EMD68025.1 - 0.24 11.3 6.0 0.5 10.3 5.9 1.6 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Peptidase_C57 PF03290.13 EMD68025.1 - 0.24 10.1 0.0 0.31 9.7 0.0 1.0 1 0 0 1 1 1 0 Vaccinia virus I7 processing peptidase zf-RING_10 PF16685.5 EMD68025.1 - 0.32 11.2 3.9 0.75 10.0 3.9 1.6 1 1 0 1 1 1 0 zinc RING finger of MSL2 zf-ANAPC11 PF12861.7 EMD68025.1 - 0.34 11.0 2.5 0.61 10.2 2.5 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-P11 PF03854.14 EMD68025.1 - 0.64 9.7 7.3 5.2 6.8 2.7 2.2 2 0 0 2 2 2 0 P-11 zinc finger MRC1 PF09444.10 EMD68026.1 - 4.1e-33 115.0 24.2 4.1e-33 115.0 24.2 8.8 8 2 1 10 10 10 2 MRC1-like domain Mut7-C PF01927.16 EMD68027.1 - 0.002 18.2 0.8 0.002 18.2 0.8 1.9 1 1 1 2 2 2 1 Mut7-C RNAse domain Zn_ribbon_SprT PF17283.2 EMD68027.1 - 2.5 8.1 6.7 3.3 7.7 5.3 1.9 2 0 0 2 2 2 0 SprT-like zinc ribbon domain LIM PF00412.22 EMD68027.1 - 3.4 8.0 9.6 9.7 6.5 9.6 1.8 1 1 0 1 1 1 0 LIM domain PDGLE PF13190.6 EMD68028.1 - 0.011 15.5 0.0 0.16 11.9 0.0 2.4 2 0 0 2 2 2 0 PDGLE domain DUF2700 PF10912.8 EMD68028.1 - 0.077 13.0 1.7 1.3 9.1 0.3 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2700) NiFe_hyd_3_EhaA PF17367.2 EMD68028.1 - 0.21 11.8 0.2 0.21 11.8 0.2 1.9 2 0 0 2 2 2 0 NiFe-hydrogenase-type-3 Eha complex subunit A MH2 PF03166.14 EMD68029.1 - 0.073 13.3 0.1 0.11 12.7 0.1 1.3 1 0 0 1 1 1 0 MH2 domain Aa_trans PF01490.18 EMD68030.1 - 1.6e-24 86.4 30.8 1.8e-24 86.2 30.8 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein MASE3 PF17159.4 EMD68030.1 - 0.92 9.1 16.3 0.47 10.0 0.9 2.9 1 1 1 2 2 2 0 Membrane-associated sensor domain Polysacc_deac_1 PF01522.21 EMD68031.1 - 5.1e-18 65.2 0.0 1.2e-17 64.0 0.0 1.6 1 0 0 1 1 1 1 Polysaccharide deacetylase DUF2334 PF10096.9 EMD68031.1 - 3.3e-05 23.6 0.1 0.00012 21.8 0.1 2.0 2 1 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2334) DUF2194 PF09960.9 EMD68031.1 - 0.14 10.4 0.0 0.19 10.0 0.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein conserved in bacteria (DUF2194) Amidase PF01425.21 EMD68032.1 - 1.8e-91 307.3 0.0 2.3e-91 307.0 0.0 1.1 1 0 0 1 1 1 1 Amidase DUF3762 PF12591.8 EMD68032.1 - 0.17 12.2 0.0 0.41 10.9 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3762) adh_short_C2 PF13561.6 EMD68033.1 - 1.5e-59 201.4 0.3 2e-59 201.0 0.3 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EMD68033.1 - 2.6e-43 147.8 0.2 3.1e-43 147.5 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EMD68033.1 - 1.4e-06 28.4 0.1 2.5e-06 27.5 0.1 1.4 1 0 0 1 1 1 1 KR domain ThiF PF00899.21 EMD68033.1 - 0.0078 15.6 1.7 0.3 10.4 0.5 2.5 3 0 0 3 3 3 2 ThiF family Fungal_trans PF04082.18 EMD68034.1 - 7.9e-18 64.4 0.3 1.1e-17 63.9 0.3 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain MFS_1 PF07690.16 EMD68035.1 - 2.9e-32 112.0 40.9 3e-31 108.6 20.9 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Iso_dh PF00180.20 EMD68036.1 - 4.3e-89 299.1 0.0 4.9e-89 298.9 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Fungal_trans PF04082.18 EMD68037.1 - 4.4e-23 81.7 2.4 4.6e-23 81.6 1.3 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain E1-E2_ATPase PF00122.20 EMD68038.1 - 1.7e-39 135.2 0.2 1.7e-39 135.2 0.2 1.9 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 EMD68038.1 - 5.4e-24 85.6 0.0 9.4e-24 84.9 0.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EMD68038.1 - 5.6e-07 29.6 0.4 2e-05 24.5 0.1 2.5 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HMA PF00403.26 EMD68038.1 - 0.00038 20.8 0.1 0.00078 19.8 0.1 1.6 1 0 0 1 1 1 1 Heavy-metal-associated domain HAD PF12710.7 EMD68038.1 - 0.0045 17.4 0.0 0.013 16.0 0.0 1.8 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EMD68038.1 - 0.02 15.0 0.2 0.12 12.5 0.1 2.2 2 1 0 2 2 2 0 Haloacid dehalogenase-like hydrolase TSLP PF15216.6 EMD68038.1 - 0.11 12.7 0.1 0.25 11.6 0.1 1.5 1 0 0 1 1 1 0 Thymic stromal lymphopoietin Acid_phosphat_B PF03767.14 EMD68038.1 - 0.15 11.7 0.0 0.27 10.8 0.0 1.3 1 0 0 1 1 1 0 HAD superfamily, subfamily IIIB (Acid phosphatase) DUF1772 PF08592.11 EMD68038.1 - 4.2 7.7 6.2 1 9.7 0.8 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1772) RseC_MucC PF04246.12 EMD68038.1 - 7 6.6 9.6 4.2 7.3 0.4 3.5 3 0 0 3 3 3 0 Positive regulator of sigma(E), RseC/MucC Rad4 PF03835.15 EMD68039.1 - 8.2e-30 103.4 0.3 1.9e-29 102.2 0.3 1.7 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain BHD_3 PF10405.9 EMD68039.1 - 7.3e-27 93.6 0.1 1.3e-26 92.8 0.1 1.4 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 3 BHD_1 PF10403.9 EMD68039.1 - 4.7e-19 68.0 0.1 8.7e-19 67.1 0.1 1.5 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 1 BHD_2 PF10404.9 EMD68039.1 - 5.4e-18 65.7 1.6 8.8e-18 65.0 0.1 2.3 2 0 0 2 2 2 1 Rad4 beta-hairpin domain 2 Transglut_core PF01841.19 EMD68039.1 - 0.00075 19.9 0.0 0.0031 18.0 0.0 2.0 1 1 0 1 1 1 1 Transglutaminase-like superfamily TFIIA PF03153.13 EMD68039.1 - 0.035 14.1 3.5 0.1 12.6 3.5 1.8 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit E1_dh PF00676.20 EMD68040.1 - 3.4e-90 302.0 0.0 4.4e-90 301.7 0.0 1.1 1 0 0 1 1 1 1 Dehydrogenase E1 component TPP_enzyme_C PF02775.21 EMD68040.1 - 0.0029 17.4 1.2 0.0069 16.2 0.1 2.2 2 1 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain KapB PF08810.10 EMD68040.1 - 0.068 13.4 0.7 0.15 12.3 0.7 1.5 1 0 0 1 1 1 0 Kinase associated protein B DXP_synthase_N PF13292.6 EMD68040.1 - 0.069 12.3 0.0 0.14 11.3 0.0 1.4 1 0 0 1 1 1 0 1-deoxy-D-xylulose-5-phosphate synthase Ubie_methyltran PF01209.18 EMD68041.1 - 2.3e-79 266.0 0.0 3e-79 265.6 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.6 EMD68041.1 - 7.1e-16 58.7 0.0 1.4e-15 57.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMD68041.1 - 2.2e-14 53.8 0.0 4.9e-14 52.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMD68041.1 - 1.4e-12 47.7 0.0 1.9e-12 47.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMD68041.1 - 3.2e-10 40.6 0.0 5.6e-10 39.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EMD68041.1 - 4.1e-07 30.0 0.0 6.4e-07 29.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 EMD68041.1 - 0.078 12.8 0.0 0.27 11.1 0.0 1.8 3 0 0 3 3 3 0 Hypothetical methyltransferase DREV PF05219.12 EMD68041.1 - 0.14 11.3 0.0 0.19 10.8 0.0 1.2 1 0 0 1 1 1 0 DREV methyltransferase DUF1152 PF06626.12 EMD68041.1 - 0.15 11.2 0.0 0.2 10.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1152) CAP_N PF01213.19 EMD68041.1 - 0.65 9.4 4.4 0.96 8.9 4.4 1.1 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal PRIMA1 PF16101.5 EMD68041.1 - 5 7.2 6.7 8.1 6.5 6.7 1.3 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 ATG13 PF10033.9 EMD68042.1 - 1.5e-63 214.7 0.0 2.7e-63 213.9 0.0 1.5 1 0 0 1 1 1 1 Autophagy-related protein 13 RCC1 PF00415.18 EMD68043.1 - 1.1e-21 77.1 0.1 4.8e-07 30.3 0.0 5.8 5 0 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EMD68043.1 - 5.1e-13 48.4 6.1 9.1e-10 38.1 0.1 4.1 4 0 0 4 4 4 2 Regulator of chromosome condensation (RCC1) repeat Ank_4 PF13637.6 EMD68043.1 - 5.5e-10 39.6 0.3 3.2e-09 37.1 0.1 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) BTB PF00651.31 EMD68043.1 - 5.6e-10 39.4 0.0 0.00068 19.8 0.0 3.0 2 1 0 2 2 2 2 BTB/POZ domain Ank_2 PF12796.7 EMD68043.1 - 1.9e-07 31.6 0.1 4.5e-07 30.4 0.1 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EMD68043.1 - 0.0012 19.1 0.1 0.66 10.4 0.0 3.4 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMD68043.1 - 0.0013 19.1 1.0 2.1 9.1 0.1 3.3 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 EMD68043.1 - 0.0037 17.6 0.3 2.2 8.9 0.0 3.1 3 0 0 3 3 3 1 Ankyrin repeat Nup96 PF12110.8 EMD68044.1 - 2.2e-84 283.0 0.7 3.1e-84 282.5 0.7 1.2 1 0 0 1 1 1 1 Nuclear protein 96 Nucleoporin2 PF04096.14 EMD68044.1 - 3e-43 147.5 0.0 5.5e-43 146.6 0.0 1.4 1 0 0 1 1 1 1 Nucleoporin autopeptidase Nucleoporin_FG PF13634.6 EMD68044.1 - 3.4e-23 82.3 224.3 1.6e-08 35.2 40.1 13.1 4 2 10 14 14 14 7 Nucleoporin FG repeat region EF-hand_1 PF00036.32 EMD68045.1 - 5.3e-21 72.5 7.6 3.5e-09 35.6 0.2 3.8 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.6 EMD68045.1 - 4.5e-20 71.9 2.9 1.9e-11 44.2 0.7 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EMD68045.1 - 9.9e-18 62.5 6.1 6.7e-08 31.9 0.2 3.9 3 1 1 4 4 4 3 EF-hand domain EF-hand_8 PF13833.6 EMD68045.1 - 1.3e-16 60.1 4.5 4e-10 39.4 0.3 3.0 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 EMD68045.1 - 5.3e-14 51.0 2.8 2.5e-05 23.6 0.1 3.6 3 0 0 3 3 3 2 EF hand EF-hand_4 PF12763.7 EMD68045.1 - 1.4e-06 28.2 0.0 0.00072 19.5 0.0 2.3 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 EMD68045.1 - 0.0034 17.7 0.1 2 8.8 0.0 3.2 2 1 0 2 2 2 1 EF-hand domain Caleosin PF05042.13 EMD68045.1 - 0.0038 17.2 0.1 0.38 10.6 0.0 2.8 1 1 3 4 4 4 1 Caleosin related protein SPARC_Ca_bdg PF10591.9 EMD68045.1 - 0.0082 16.5 0.9 1.3 9.4 0.0 2.3 2 1 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region DUF4834 PF16118.5 EMD68045.1 - 0.01 16.8 0.3 0.18 12.8 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) EF-hand_11 PF08976.11 EMD68045.1 - 0.063 14.2 0.1 0.19 12.6 0.1 1.9 1 1 0 1 1 1 0 EF-hand domain DUF1296 PF06972.11 EMD68045.1 - 0.083 13.0 0.4 0.41 10.8 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1296) Complex1_51K PF01512.17 EMD68046.1 - 2e-47 160.9 0.0 3.6e-47 160.1 0.0 1.4 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase 51 Kd subunit NADH_4Fe-4S PF10589.9 EMD68046.1 - 2.6e-29 101.1 1.4 3.6e-29 100.7 0.2 1.9 2 0 0 2 2 2 1 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region SLBB PF10531.9 EMD68046.1 - 7.5e-09 35.3 0.1 3.4e-08 33.2 0.0 2.1 2 0 0 2 2 2 1 SLBB domain GHMP_kinases_C PF08544.13 EMD68046.1 - 0.11 12.9 0.0 24 5.4 0.0 2.5 2 0 0 2 2 2 0 GHMP kinases C terminal DUF3568 PF12092.8 EMD68046.1 - 0.14 12.2 0.4 0.27 11.3 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3568) CN_hydrolase PF00795.22 EMD68048.1 - 2.4e-30 105.7 0.0 3.2e-30 105.3 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase FMN_dh PF01070.18 EMD68049.1 - 2e-87 293.5 0.0 1e-46 159.6 0.0 2.0 1 1 1 2 2 2 2 FMN-dependent dehydrogenase IMPDH PF00478.25 EMD68049.1 - 0.00053 19.1 0.1 0.0012 18.0 0.1 1.6 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain His_biosynth PF00977.21 EMD68049.1 - 0.00062 19.3 0.4 0.37 10.2 0.0 3.0 1 1 2 3 3 3 2 Histidine biosynthesis protein Glu_synthase PF01645.17 EMD68049.1 - 0.0098 15.1 0.0 0.015 14.4 0.0 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase DHO_dh PF01180.21 EMD68049.1 - 0.016 14.4 0.2 2.1 7.5 0.0 2.7 2 1 1 3 3 3 0 Dihydroorotate dehydrogenase QRPTase_C PF01729.19 EMD68049.1 - 0.11 12.3 0.0 0.21 11.3 0.0 1.4 1 0 0 1 1 1 0 Quinolinate phosphoribosyl transferase, C-terminal domain NMO PF03060.15 EMD68049.1 - 0.11 11.8 0.0 0.21 11.0 0.0 1.4 1 0 0 1 1 1 0 Nitronate monooxygenase Peptidase_M14 PF00246.24 EMD68051.1 - 4.2e-39 135.1 0.6 6.1e-39 134.5 0.6 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase AstE_AspA PF04952.14 EMD68051.1 - 0.11 11.6 0.0 2.3 7.2 0.0 2.9 3 1 0 3 3 3 0 Succinylglutamate desuccinylase / Aspartoacylase family AMP-binding PF00501.28 EMD68052.1 - 1.1e-70 238.4 0.0 1.6e-70 237.8 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EMD68052.1 - 0.0025 18.8 0.0 0.0087 17.0 0.0 2.0 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Sh_2 PF17512.2 EMD68052.1 - 0.12 12.1 0.5 0.24 11.1 0.5 1.4 1 0 0 1 1 1 0 Metapneumovirus Small hydrophobic protein Mif2_N PF15624.6 EMD68055.1 - 1.3 9.7 9.3 0.74 10.5 6.5 1.9 2 0 0 2 2 2 0 Kinetochore CENP-C fungal homologue, Mif2, N-terminal MAP65_ASE1 PF03999.12 EMD68055.1 - 2 7.1 5.5 2 7.0 5.5 1.1 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) FAD_binding_4 PF01565.23 EMD68056.1 - 6.4e-22 77.8 0.2 1.8e-21 76.3 0.2 1.8 1 1 0 1 1 1 1 FAD binding domain BBE PF08031.12 EMD68056.1 - 0.0036 17.4 0.0 0.014 15.4 0.0 2.0 2 0 0 2 2 2 1 Berberine and berberine like Response_reg PF00072.24 EMD68057.1 - 3e-17 62.8 0.3 1.8e-16 60.3 0.1 2.5 2 1 0 2 2 2 1 Response regulator receiver domain HisKA PF00512.25 EMD68057.1 - 8.2e-10 38.6 0.0 2.8e-09 36.9 0.0 1.9 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain Helo_like_N PF17111.5 EMD68060.1 - 4.3e-06 26.3 0.6 5.1e-06 26.0 0.6 1.1 1 0 0 1 1 1 1 Fungal N-terminal domain of STAND proteins SesA PF17107.5 EMD68060.1 - 7.1e-06 26.2 0.6 9.1e-06 25.9 0.6 1.1 1 0 0 1 1 1 1 N-terminal domain on NACHT_NTPase and P-loop NTPases SKA1 PF07160.12 EMD68060.1 - 0.00082 19.3 0.1 0.00095 19.1 0.1 1.1 1 0 0 1 1 1 1 Spindle and kinetochore-associated protein 1 Laminin_II PF06009.12 EMD68060.1 - 0.012 15.6 0.1 0.021 14.8 0.1 1.4 1 0 0 1 1 1 0 Laminin Domain II ISG65-75 PF11727.8 EMD68060.1 - 0.069 12.4 0.1 0.1 11.8 0.1 1.2 1 0 0 1 1 1 0 Invariant surface glycoprotein Rx_N PF18052.1 EMD68060.1 - 0.07 13.4 0.1 0.12 12.6 0.1 1.4 1 0 0 1 1 1 0 Rx N-terminal domain Gp58 PF07902.11 EMD68060.1 - 0.096 11.0 2.0 0.66 8.2 2.0 1.8 1 1 0 1 1 1 0 gp58-like protein CN_hydrolase PF00795.22 EMD68061.1 - 1e-28 100.4 0.0 1.4e-28 100.0 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase NAD_synthase PF02540.17 EMD68061.1 - 3.8e-26 91.7 0.0 2.2e-25 89.2 0.0 2.0 1 1 0 1 1 1 1 NAD synthase Asn_synthase PF00733.21 EMD68061.1 - 0.11 12.2 0.0 0.21 11.2 0.0 1.4 1 0 0 1 1 1 0 Asparagine synthase HATPase_c PF02518.26 EMD68062.1 - 2.6e-24 85.9 0.1 9.9e-24 84.0 0.0 1.9 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EMD68062.1 - 1.3e-21 76.9 0.9 3.5e-21 75.5 0.3 2.0 2 0 0 2 2 2 1 Response regulator receiver domain HisKA PF00512.25 EMD68062.1 - 5.4e-14 52.0 0.1 1.7e-13 50.4 0.1 1.9 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_3 PF13589.6 EMD68062.1 - 0.056 13.3 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Reticulon PF02453.17 EMD68064.1 - 5.1e-36 124.0 1.5 8e-36 123.4 1.5 1.3 1 0 0 1 1 1 1 Reticulon Apo-CIII PF05778.12 EMD68064.1 - 0.07 12.8 0.2 0.18 11.4 0.2 1.7 1 0 0 1 1 1 0 Apolipoprotein CIII (Apo-CIII) DUF2515 PF10720.9 EMD68065.1 - 0.077 12.2 0.6 0.13 11.4 0.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2515) Cupin_8 PF13621.6 EMD68066.1 - 2.1e-34 119.4 0.0 3.3e-34 118.8 0.0 1.2 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 EMD68066.1 - 8.4e-07 28.7 0.0 0.00011 21.7 0.0 2.3 2 0 0 2 2 2 2 Cupin superfamily protein TFA2_Winged_2 PF18121.1 EMD68068.1 - 5.1e-16 58.1 0.4 1.5e-15 56.6 0.1 2.0 2 0 0 2 2 2 1 TFA2 Winged helix domain 2 TFIIE_beta PF02186.15 EMD68068.1 - 3.1e-15 56.2 0.2 6.6e-15 55.1 0.2 1.6 1 0 0 1 1 1 1 TFIIE beta subunit core domain CFEM PF05730.11 EMD68069.1 - 4.8e-11 42.6 15.6 9.9e-11 41.6 15.6 1.6 1 0 0 1 1 1 1 CFEM domain TIL PF01826.17 EMD68069.1 - 7.5 6.9 10.4 17 5.7 10.4 1.6 1 0 0 1 1 1 0 Trypsin Inhibitor like cysteine rich domain adh_short PF00106.25 EMD68070.1 - 5.7e-39 133.6 0.0 8.9e-39 133.0 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD68070.1 - 8.2e-23 81.2 0.0 9.9e-23 80.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD68070.1 - 2.9e-07 30.6 0.0 5e-07 29.8 0.0 1.4 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 EMD68070.1 - 7.1e-07 28.9 0.0 1.7e-06 27.7 0.0 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Sacchrp_dh_NADP PF03435.18 EMD68070.1 - 5.8e-05 23.3 0.1 0.00023 21.4 0.1 1.8 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_10 PF13460.6 EMD68070.1 - 9.5e-05 22.4 0.0 0.00013 21.9 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding F420_oxidored PF03807.17 EMD68070.1 - 0.00059 20.4 0.1 0.00098 19.7 0.1 1.4 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.20 EMD68070.1 - 0.00068 19.7 0.0 0.00095 19.2 0.0 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase DUF1776 PF08643.10 EMD68070.1 - 0.00076 18.9 0.0 0.00083 18.8 0.0 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) TrkA_N PF02254.18 EMD68070.1 - 0.024 14.9 0.2 0.044 14.1 0.2 1.4 1 0 0 1 1 1 0 TrkA-N domain Polysacc_synt_2 PF02719.15 EMD68070.1 - 0.036 13.2 0.0 0.05 12.7 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein ApbA PF02558.16 EMD68070.1 - 0.095 12.3 0.0 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA NAD_binding_2 PF03446.15 EMD68070.1 - 0.13 12.5 0.0 0.23 11.6 0.0 1.5 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Eno-Rase_NADH_b PF12242.8 EMD68070.1 - 0.15 11.9 0.1 0.29 10.9 0.1 1.5 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase NAD_Gly3P_dh_N PF01210.23 EMD68070.1 - 0.19 11.7 0.0 0.29 11.1 0.0 1.3 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus GDP_Man_Dehyd PF16363.5 EMD68070.1 - 0.22 10.9 0.1 1.3 8.3 0.0 1.9 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase SH3_1 PF00018.28 EMD68071.1 - 1.4e-13 50.2 0.1 2.1e-13 49.6 0.1 1.3 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EMD68071.1 - 1.5e-09 37.5 0.0 2.3e-09 36.9 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EMD68071.1 - 9.7e-09 34.8 0.0 1.4e-08 34.2 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain Tyrosinase PF00264.20 EMD68072.1 - 2.9e-55 188.0 1.2 3.4e-55 187.7 0.1 1.6 2 0 0 2 2 2 1 Common central domain of tyrosinase DUF456 PF04306.13 EMD68073.1 - 2 8.7 9.0 0.11 12.8 1.4 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF456) Glyco_tran_28_C PF04101.16 EMD68078.1 - 1e-17 64.6 0.0 1.2e-17 64.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain UDPGT PF00201.18 EMD68078.1 - 0.14 11.0 0.0 0.18 10.6 0.0 1.1 1 0 0 1 1 1 0 UDP-glucoronosyl and UDP-glucosyl transferase MRP-S28 PF10213.9 EMD68079.1 - 9.8e-44 148.8 0.0 1.6e-43 148.1 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit protein Ino80_Iec3 PF14612.6 EMD68080.1 - 8.8e-78 262.2 2.3 8.8e-78 262.2 2.3 1.7 2 0 0 2 2 2 1 IEC3 subunit of the Ino80 complex, chromatin re-modelling GvpG PF05120.12 EMD68080.1 - 0.059 13.4 0.5 0.16 12.0 0.0 2.0 2 0 0 2 2 2 0 Gas vesicle protein G SHOCT PF09851.9 EMD68080.1 - 0.08 12.7 0.1 0.17 11.6 0.1 1.6 1 0 0 1 1 1 0 Short C-terminal domain ORMDL PF04061.14 EMD68081.1 - 1.3e-56 190.1 1.4 1.5e-56 189.9 1.4 1.0 1 0 0 1 1 1 1 ORMDL family Na_H_Exchanger PF00999.21 EMD68082.1 - 2.7e-55 187.7 28.6 3.5e-55 187.3 28.6 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Peptidase_M20 PF01546.28 EMD68083.1 - 7.4e-34 117.3 0.0 1.3e-33 116.4 0.0 1.5 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EMD68083.1 - 1.1e-11 44.6 0.0 3e-11 43.2 0.0 1.8 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 EMD68083.1 - 5.2e-05 23.0 0.2 0.0055 16.4 0.1 3.2 3 1 0 3 3 3 1 Peptidase family M28 Glyco_hydro_18 PF00704.28 EMD68086.1 - 8.2e-40 137.4 0.5 1.1e-33 117.3 0.1 2.1 1 1 0 2 2 2 2 Glycosyl hydrolases family 18 Nipped-B_C PF12830.7 EMD68086.1 - 0.14 12.1 0.0 0.22 11.4 0.0 1.3 1 0 0 1 1 1 0 Sister chromatid cohesion C-terminus Neuromodulin_N PF10580.9 EMD68086.1 - 1.4 8.8 3.4 29 4.6 0.4 2.5 2 0 0 2 2 2 0 Gap junction protein N-terminal region DUF4428 PF14471.6 EMD68087.1 - 0.03 14.2 0.5 0.11 12.4 0.1 2.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4428) RGS PF00615.19 EMD68088.1 - 0.00021 21.6 0.2 0.00082 19.6 0.2 1.8 1 1 0 1 1 1 1 Regulator of G protein signaling domain UNC-93 PF05978.16 EMD68088.1 - 0.037 13.7 0.0 0.097 12.4 0.0 1.6 1 0 0 1 1 1 0 Ion channel regulatory protein UNC-93 DUF2721 PF11026.8 EMD68088.1 - 0.15 11.9 0.1 0.15 11.9 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) ATP_bind_3 PF01171.20 EMD68089.1 - 7.5e-18 64.9 0.0 1.2e-17 64.3 0.0 1.3 1 0 0 1 1 1 1 PP-loop family zn-ribbon_14 PF16503.5 EMD68089.1 - 5.8e-17 60.9 4.9 5.8e-17 60.9 4.9 3.2 4 0 0 4 4 4 1 Zinc-ribbon RecR PF02132.15 EMD68089.1 - 0.011 15.3 1.0 0.011 15.3 1.0 3.6 4 0 0 4 4 4 0 RecR protein tRNA_Me_trans PF03054.16 EMD68089.1 - 0.016 14.0 0.0 0.029 13.2 0.0 1.4 1 0 0 1 1 1 0 tRNA methyl transferase zf-UBR PF02207.20 EMD68089.1 - 0.38 11.0 7.4 3.4 7.9 0.9 2.5 2 0 0 2 2 2 0 Putative zinc finger in N-recognin (UBR box) Glyco_hydro_31 PF01055.26 EMD68090.1 - 3.5e-155 517.5 12.2 4.6e-155 517.1 12.2 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.5 EMD68090.1 - 2.4e-37 127.6 0.4 5.2e-37 126.6 0.4 1.5 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Gal_mutarotas_2 PF13802.6 EMD68090.1 - 2.7e-12 46.8 0.8 2.7e-12 46.8 0.8 2.4 2 0 0 2 2 2 1 Galactose mutarotase-like Dynamin_N PF00350.23 EMD68091.1 - 6.4e-14 52.4 0.7 4.8e-12 46.2 0.0 3.2 4 0 0 4 4 4 1 Dynamin family MMR_HSR1 PF01926.23 EMD68091.1 - 0.0037 17.3 0.3 0.075 13.1 0.3 2.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.16 EMD68091.1 - 0.0091 15.3 1.2 0.035 13.4 0.1 2.3 2 0 0 2 2 2 1 AIG1 family T2SSE PF00437.20 EMD68091.1 - 0.02 14.0 0.0 0.057 12.5 0.0 1.7 1 0 0 1 1 1 0 Type II/IV secretion system protein IIGP PF05049.13 EMD68091.1 - 0.026 13.6 0.0 0.026 13.6 0.0 2.1 3 0 0 3 3 3 0 Interferon-inducible GTPase (IIGP) ABC_tran PF00005.27 EMD68091.1 - 0.05 14.1 4.0 0.12 12.9 0.0 3.3 4 0 0 4 4 4 0 ABC transporter Roc PF08477.13 EMD68091.1 - 0.064 13.5 2.0 9.6 6.4 0.1 3.8 5 0 0 5 5 5 0 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.6 EMD68091.1 - 0.1 13.0 0.1 3.5 8.0 0.0 2.9 2 1 0 2 2 2 0 AAA ATPase domain DUF87 PF01935.17 EMD68091.1 - 0.24 11.4 2.8 0.26 11.4 0.0 2.4 3 0 0 3 3 3 0 Helicase HerA, central domain HECT PF00632.25 EMD68092.1 - 1.6e-82 277.4 0.0 2.6e-82 276.7 0.0 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Fungal_trans_2 PF11951.8 EMD68092.1 - 2.8e-12 46.1 4.6 4.3e-12 45.5 2.2 2.3 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD68092.1 - 2.5e-07 30.7 11.2 5.2e-07 29.7 11.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain IQ PF00612.27 EMD68092.1 - 0.00088 18.9 1.7 0.0035 17.0 1.7 2.1 1 0 0 1 1 1 1 IQ calmodulin-binding motif COR PF16095.5 EMD68092.1 - 0.11 12.3 0.1 8.1 6.2 0.0 2.4 2 0 0 2 2 2 0 C-terminal of Roc, COR, domain DUF2703 PF10865.8 EMD68092.1 - 0.46 10.7 2.1 22 5.2 0.0 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF2703) ENTH PF01417.20 EMD68094.1 - 1.9e-46 157.2 0.0 2.8e-46 156.6 0.0 1.3 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.16 EMD68094.1 - 0.0015 17.6 0.0 0.0026 16.8 0.0 1.3 1 0 0 1 1 1 1 ANTH domain DUF4264 PF14084.6 EMD68094.1 - 0.0031 17.1 0.0 0.0065 16.1 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF4264) UIM PF02809.20 EMD68094.1 - 0.025 14.5 6.1 0.13 12.3 0.2 2.9 2 0 0 2 2 2 0 Ubiquitin interaction motif zf-C2H2 PF00096.26 EMD68095.1 - 8.8e-22 76.3 25.4 3.7e-05 24.0 1.7 4.6 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMD68095.1 - 2.4e-18 65.6 25.4 1.7e-06 28.2 1.2 5.5 5 0 0 5 5 5 4 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMD68095.1 - 4.6e-12 45.7 22.7 0.0042 17.8 1.3 4.6 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EMD68095.1 - 1e-06 28.8 0.1 2.3 8.6 0.0 4.8 4 0 0 4 4 4 1 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.5 EMD68095.1 - 0.0018 18.0 9.2 0.02 14.6 0.8 3.5 3 0 0 3 3 3 2 zinc-finger C2H2-type zf_UBZ PF18439.1 EMD68095.1 - 0.0093 15.5 1.7 1.2 8.8 0.2 3.1 3 0 0 3 3 3 1 Ubiquitin-Binding Zinc Finger zf-met PF12874.7 EMD68095.1 - 0.02 15.3 13.3 1.8 9.1 0.0 4.5 5 0 0 5 5 5 0 Zinc-finger of C2H2 type FOXP-CC PF16159.5 EMD68095.1 - 0.1 13.2 2.0 14 6.4 0.3 3.0 2 1 1 3 3 3 0 FOXP coiled-coil domain zf-C2HC_2 PF13913.6 EMD68095.1 - 0.55 10.2 6.9 17 5.4 0.2 3.5 3 0 0 3 3 3 0 zinc-finger of a C2HC-type DUF4764 PF15961.5 EMD68095.1 - 0.88 8.2 7.1 0.32 9.6 0.7 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4764) Zn-ribbon_8 PF09723.10 EMD68095.1 - 0.93 9.7 8.7 3 8.0 0.9 3.2 1 1 3 4 4 4 0 Zinc ribbon domain DZR PF12773.7 EMD68095.1 - 1.1 9.4 8.0 74 3.5 8.0 2.4 1 1 0 1 1 1 0 Double zinc ribbon zf-LYAR PF08790.11 EMD68095.1 - 3.2 7.8 4.9 6.2 6.8 0.1 3.4 4 0 0 4 4 4 0 LYAR-type C2HC zinc finger DUF2256 PF10013.9 EMD68095.1 - 5.8 7.1 8.2 22 5.2 0.0 3.6 4 0 0 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2256) Ogr_Delta PF04606.12 EMD68095.1 - 7.2 6.7 9.4 13 5.9 0.5 2.5 2 0 0 2 2 2 0 Ogr/Delta-like zinc finger NAD_binding_1 PF00175.21 EMD68097.1 - 2.5e-13 50.6 0.0 4.9e-13 49.7 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Globin PF00042.22 EMD68097.1 - 6.6e-10 39.5 0.1 1.4e-09 38.5 0.1 1.6 1 0 0 1 1 1 1 Globin NAD_binding_6 PF08030.12 EMD68097.1 - 0.00012 22.2 0.0 0.062 13.4 0.0 2.8 2 1 1 3 3 3 2 Ferric reductase NAD binding domain Protoglobin PF11563.8 EMD68097.1 - 0.00089 19.2 0.1 0.0015 18.4 0.1 1.3 1 0 0 1 1 1 1 Protoglobin Inositol_P PF00459.25 EMD68099.1 - 6.6e-53 180.0 0.8 1.7e-52 178.6 0.8 1.6 1 1 0 1 1 1 1 Inositol monophosphatase family TRC8_N PF13705.6 EMD68099.1 - 0.8 8.5 2.6 1.1 8.1 2.6 1.1 1 0 0 1 1 1 0 TRC8 N-terminal domain zf-C3HC PF07967.13 EMD68100.1 - 2.2e-37 128.0 0.2 1.5e-28 99.5 0.2 2.4 2 0 0 2 2 2 2 C3HC zinc finger-like Rsm1 PF08600.10 EMD68100.1 - 1.1e-23 83.2 0.3 1.3e-22 79.7 0.2 2.5 2 0 0 2 2 2 1 Rsm1-like F-box-like PF12937.7 EMD68101.1 - 0.13 12.2 1.5 0.34 10.8 0.3 2.2 2 0 0 2 2 2 0 F-box-like Fungal_trans PF04082.18 EMD68102.1 - 0.17 10.9 0.8 0.38 9.7 0.1 1.9 2 0 0 2 2 2 0 Fungal specific transcription factor domain zf-RING_2 PF13639.6 EMD68103.1 - 4.3e-09 36.6 1.9 6.2e-09 36.1 1.9 1.2 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 EMD68103.1 - 1.6e-06 28.3 3.1 8.3e-06 26.0 3.1 1.9 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 EMD68103.1 - 0.00064 19.7 0.4 0.00094 19.2 0.4 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_2 PF13923.6 EMD68103.1 - 0.001 18.9 3.3 0.0022 17.8 3.3 1.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EMD68103.1 - 0.0018 18.0 1.3 0.0029 17.3 1.3 1.4 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_UBOX PF13445.6 EMD68103.1 - 0.003 17.5 4.8 0.0056 16.7 4.8 1.4 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EMD68103.1 - 0.018 14.9 0.9 0.03 14.2 0.9 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) MFS_1 PF07690.16 EMD68105.1 - 8e-25 87.5 59.6 2.9e-15 56.0 30.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily SLBB PF10531.9 EMD68105.1 - 0.017 15.0 0.1 0.053 13.4 0.1 1.9 1 0 0 1 1 1 0 SLBB domain WD40 PF00400.32 EMD68107.1 - 4.5e-29 100.1 14.1 3e-05 24.7 0.1 7.9 8 0 0 8 8 8 5 WD domain, G-beta repeat F-box-like PF12937.7 EMD68107.1 - 1.1e-10 41.3 1.9 2.3e-10 40.2 1.9 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EMD68107.1 - 1.2e-06 28.3 0.6 2.2e-06 27.4 0.6 1.5 1 0 0 1 1 1 1 F-box domain ANAPC4_WD40 PF12894.7 EMD68107.1 - 5.5e-06 26.6 0.1 4.7 7.6 0.0 4.1 2 2 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EMD68107.1 - 1.4e-05 24.0 0.1 0.28 9.8 0.0 3.2 3 0 0 3 3 3 3 Nucleoporin Nup120/160 BBS2_Mid PF14783.6 EMD68107.1 - 0.01 15.9 0.0 31 4.7 0.0 3.8 3 1 0 3 3 3 0 Ciliary BBSome complex subunit 2, middle region WD40_like PF17005.5 EMD68107.1 - 0.026 13.9 0.2 5.1 6.3 0.0 3.1 3 1 1 4 4 4 0 WD40-like domain PH_10 PF15411.6 EMD68108.1 - 5e-38 130.1 0.5 1.2e-37 128.9 0.5 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain CDC24 PF06395.11 EMD68108.1 - 3.3e-32 110.6 0.1 1.4e-31 108.6 0.0 2.0 2 0 0 2 2 2 1 CDC24 Calponin RhoGEF PF00621.20 EMD68108.1 - 1.9e-28 100.0 0.1 3.5e-28 99.1 0.1 1.5 1 0 0 1 1 1 1 RhoGEF domain PB1 PF00564.24 EMD68108.1 - 1.6e-10 40.8 0.0 4e-10 39.5 0.0 1.7 1 0 0 1 1 1 1 PB1 domain PH PF00169.29 EMD68108.1 - 0.08 13.5 0.1 0.19 12.2 0.1 1.6 1 0 0 1 1 1 0 PH domain dsrm PF00035.26 EMD68109.1 - 0.02 15.6 0.0 0.055 14.2 0.0 1.8 1 1 0 1 1 1 0 Double-stranded RNA binding motif DND1_DSRM PF14709.7 EMD68109.1 - 0.14 12.4 0.8 0.57 10.5 0.8 2.1 1 1 0 1 1 1 0 double strand RNA binding domain from DEAD END PROTEIN 1 Dabb PF07876.12 EMD68110.1 - 0.0014 19.2 0.0 0.0017 18.9 0.0 1.1 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain NTP_transferase PF00483.23 EMD68112.1 - 3.4e-52 177.5 0.0 6.2e-52 176.6 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep PF00132.24 EMD68112.1 - 1.4e-14 53.1 6.5 1.2e-10 40.6 0.8 3.3 2 1 0 2 2 2 2 Bacterial transferase hexapeptide (six repeats) 2_5_RNA_ligase2 PF13563.6 EMD68112.1 - 7.2e-14 52.0 0.0 1.4e-13 51.0 0.0 1.5 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily NTP_transf_3 PF12804.7 EMD68112.1 - 3.7e-11 43.6 0.0 7.6e-11 42.6 0.0 1.6 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep_2 PF14602.6 EMD68112.1 - 1.9e-07 30.7 7.7 2.1e-06 27.4 0.5 3.0 2 1 0 2 2 2 2 Hexapeptide repeat of succinyl-transferase DUF4954 PF16314.5 EMD68112.1 - 0.0075 14.5 0.1 0.032 12.4 0.0 1.9 2 1 1 3 3 3 1 Domain of unknown function (DUF4954) CTP_transf_3 PF02348.19 EMD68112.1 - 0.018 15.0 0.0 0.05 13.5 0.0 1.8 1 0 0 1 1 1 0 Cytidylyltransferase IspD PF01128.19 EMD68112.1 - 0.1 12.3 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase ubiquitin PF00240.23 EMD68114.1 - 1.4e-137 447.7 17.0 1.2e-33 114.7 0.4 4.0 4 0 0 4 4 4 4 Ubiquitin family Rad60-SLD PF11976.8 EMD68114.1 - 4.2e-65 215.5 20.3 1.1e-15 57.2 0.6 4.0 4 0 0 4 4 4 4 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EMD68114.1 - 5.5e-23 81.2 7.5 0.00066 20.1 0.1 5.8 4 4 0 4 4 4 4 Ubiquitin-like domain TBK1_ULD PF18396.1 EMD68114.1 - 5.4e-16 58.3 3.0 0.035 14.0 0.0 4.2 4 0 0 4 4 4 4 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD_2 PF13881.6 EMD68114.1 - 4.3e-14 52.6 2.7 0.15 12.2 0.0 5.0 4 4 0 4 4 4 4 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 EMD68114.1 - 4.8e-14 52.5 7.8 0.056 13.8 0.1 4.1 4 0 0 4 4 4 4 Ubiquitin-like domain DUF2407 PF10302.9 EMD68114.1 - 2.3e-13 50.6 0.8 0.33 11.5 0.0 4.2 1 1 2 4 4 4 4 DUF2407 ubiquitin-like domain Sde2_N_Ubi PF13019.6 EMD68114.1 - 5e-08 32.9 0.3 3.2 7.6 0.0 4.2 1 1 3 4 4 4 4 Silencing defective 2 N-terminal ubiquitin domain Methyltrans_RNA PF04452.14 EMD68114.1 - 4.9e-07 29.3 0.6 0.98 8.7 0.0 3.3 3 0 0 3 3 3 3 RNA methyltransferase Ubiquitin_4 PF18036.1 EMD68114.1 - 1.8e-06 27.9 24.2 16 5.7 0.2 7.9 8 0 0 8 8 8 0 Ubiquitin-like domain TmoB PF06234.12 EMD68114.1 - 3.9e-06 26.8 4.5 12 6.0 0.0 5.3 4 4 0 4 4 4 0 Toluene-4-monooxygenase system protein B (TmoB) Big_7 PF17957.1 EMD68114.1 - 4.4e-06 27.4 0.1 30 5.5 0.0 4.1 4 0 0 4 4 4 0 Bacterial Ig domain DUF3861 PF12977.7 EMD68114.1 - 4.6e-06 26.7 3.0 13 6.0 0.0 4.2 4 0 0 4 4 4 0 Domain of Unknown Function with PDB structure (DUF3861) ACT_5 PF13710.6 EMD68114.1 - 1e-05 25.3 3.8 11 5.9 0.0 4.3 4 0 0 4 4 4 0 ACT domain DUF2870 PF11069.8 EMD68114.1 - 4.1e-05 23.9 0.0 49 4.4 0.0 4.8 4 0 0 4 4 4 0 Protein of unknown function (DUF2870) UDP-g_GGTase PF06427.11 EMD68114.1 - 5.7e-05 23.2 2.2 8.5 6.5 0.0 4.0 4 0 0 4 4 4 0 UDP-glucose:Glycoprotein Glucosyltransferase DUF969 PF06149.12 EMD68114.1 - 0.00025 20.5 0.1 20 4.5 0.0 3.9 4 0 0 4 4 4 0 Protein of unknown function (DUF969) ACT_4 PF13291.6 EMD68114.1 - 0.00036 21.0 0.9 73 4.1 0.0 4.2 4 0 0 4 4 4 0 ACT domain NEAT PF05031.12 EMD68114.1 - 0.0018 18.9 1.2 2.8 8.6 0.9 2.8 1 1 1 2 2 2 2 Iron Transport-associated domain DUF493 PF04359.14 EMD68114.1 - 0.003 18.1 0.1 1.4e+02 3.1 0.0 4.0 4 0 0 4 4 4 0 Protein of unknown function (DUF493) ProRS-C_2 PF09181.10 EMD68114.1 - 0.011 15.9 5.3 64 3.8 0.1 4.1 4 0 0 4 4 4 0 Prolyl-tRNA synthetase, C-terminal YukD PF08817.10 EMD68114.1 - 0.032 14.9 0.4 2.5e+02 2.5 0.0 4.1 4 0 0 4 4 4 0 WXG100 protein secretion system (Wss), protein YukD ORF11CD3 PF10549.9 EMD68114.1 - 0.039 14.1 0.0 1.5e+02 2.6 0.0 4.1 4 0 0 4 4 4 0 ORF11CD3 domain FlgD_ig PF13860.6 EMD68114.1 - 0.041 13.8 9.2 43 4.1 0.1 4.4 4 0 0 4 4 4 0 FlgD Ig-like domain Phage_sheath_1N PF17481.2 EMD68114.1 - 0.067 13.7 8.7 47 4.5 0.1 4.0 1 1 3 4 4 4 0 Phage tail sheath protein beta-sandwich domain Tash_PEST PF07708.11 EMD68114.1 - 0.15 12.3 27.2 6.2 7.1 1.4 4.3 4 0 0 4 4 4 0 Tash protein PEST motif YcgR_2 PF12945.7 EMD68114.1 - 1.1 9.5 4.6 2.4e+02 2.0 0.0 4.0 4 0 0 4 4 4 0 Flagellar protein YcgR PI3K_p85B PF02192.16 EMD68114.1 - 1.2 8.9 8.5 96 2.8 0.1 4.2 4 0 0 4 4 4 0 PI3-kinase family, p85-binding domain Cnl2_NKP2 PF09447.10 EMD68114.1 - 1.3 9.2 9.9 1e+02 3.2 0.1 4.3 4 0 0 4 4 4 0 Cnl2/NKP2 family protein Aldo_ket_red PF00248.21 EMD68115.1 - 1.4e-66 224.7 0.2 1.6e-66 224.5 0.2 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family BMC PF00936.19 EMD68116.1 - 0.09 12.8 0.1 0.11 12.4 0.1 1.3 1 0 0 1 1 1 0 BMC domain Zn_clus PF00172.18 EMD68117.1 - 0.0051 16.9 7.8 0.012 15.7 7.8 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Herpes_BMRF2 PF04633.12 EMD68117.1 - 0.16 11.2 0.0 0.26 10.5 0.0 1.2 1 0 0 1 1 1 0 Herpesvirus BMRF2 protein Cupin_2 PF07883.11 EMD68118.1 - 8.1e-07 28.7 0.0 1.4e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 Cupin domain Prenyltrans PF00432.21 EMD68119.1 - 3.2e-33 113.1 26.4 3.5e-08 33.0 3.4 5.4 5 0 0 5 5 5 5 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_N PF13249.6 EMD68119.1 - 0.052 12.6 0.3 2.9 6.9 0.1 2.8 2 1 1 3 3 3 0 Squalene-hopene cyclase N-terminal domain ARID PF01388.21 EMD68120.1 - 1e-20 74.2 0.0 2.7e-20 72.8 0.0 1.8 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain RFX_DNA_binding PF02257.15 EMD68120.1 - 0.013 16.1 0.0 0.024 15.2 0.0 1.5 1 0 0 1 1 1 0 RFX DNA-binding domain GARP PF16731.5 EMD68120.1 - 0.017 14.8 0.1 0.03 14.0 0.1 1.3 1 0 0 1 1 1 0 Glutamic acid/alanine-rich protein of Trypanosoma Diphthamide_syn PF01866.17 EMD68122.1 - 1.7e-88 297.0 0.0 3.5e-88 295.9 0.0 1.5 1 1 0 1 1 1 1 Putative diphthamide synthesis protein PTPRCAP PF15713.5 EMD68122.1 - 0.067 13.5 7.7 0.05 13.9 3.3 2.2 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated PLA2_B PF01735.18 EMD68123.1 - 3.4e-179 596.4 1.0 4e-179 596.1 1.0 1.0 1 0 0 1 1 1 1 Lysophospholipase catalytic domain COesterase PF00135.28 EMD68124.1 - 1.3e-74 251.9 0.1 3.5e-74 250.5 0.1 1.5 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EMD68124.1 - 6.1e-09 36.0 0.1 1.7e-08 34.6 0.1 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold DIOX_N PF14226.6 EMD68125.1 - 1.9e-28 99.6 0.0 3.1e-28 98.9 0.0 1.4 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EMD68125.1 - 5.6e-20 71.7 0.0 1.1e-19 70.8 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily NTP_transferase PF00483.23 EMD68126.1 - 2e-31 109.5 0.0 2.9e-31 108.9 0.0 1.2 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep PF00132.24 EMD68126.1 - 1.4e-12 46.8 7.2 5.4e-08 32.3 0.3 3.5 3 0 0 3 3 3 3 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.7 EMD68126.1 - 3.9e-08 33.8 0.0 7.1e-08 33.0 0.0 1.5 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep_2 PF14602.6 EMD68126.1 - 0.023 14.5 2.2 0.18 11.6 0.1 3.1 4 0 0 4 4 4 0 Hexapeptide repeat of succinyl-transferase DUF4954 PF16314.5 EMD68126.1 - 0.06 11.5 0.4 0.1 10.7 0.0 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4954) IspD PF01128.19 EMD68126.1 - 0.11 12.2 0.0 0.22 11.2 0.0 1.4 1 0 0 1 1 1 0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase zf-RING_4 PF14570.6 EMD68128.1 - 1.6e-20 72.6 12.5 3e-20 71.7 12.5 1.5 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain RRM_1 PF00076.22 EMD68128.1 - 4.1e-09 36.1 0.0 1.1e-08 34.8 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-C3HC4_3 PF13920.6 EMD68128.1 - 2.6e-07 30.4 10.5 5.2e-07 29.4 10.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) SET_assoc PF11767.8 EMD68128.1 - 0.0022 17.6 0.0 0.0048 16.5 0.0 1.5 1 0 0 1 1 1 1 Histone lysine methyltransferase SET associated Rtf2 PF04641.12 EMD68128.1 - 0.0037 16.7 3.1 0.0037 16.7 3.1 3.4 4 0 0 4 4 4 1 Rtf2 RING-finger FYVE PF01363.21 EMD68128.1 - 0.0043 17.2 5.9 0.011 15.9 5.9 1.7 1 0 0 1 1 1 1 FYVE zinc finger zf-RING_2 PF13639.6 EMD68128.1 - 0.0054 17.0 13.3 0.0098 16.2 13.3 1.4 1 0 0 1 1 1 1 Ring finger domain Baculo_IE-1 PF05290.11 EMD68128.1 - 0.0069 16.3 6.1 0.014 15.4 6.1 1.4 1 0 0 1 1 1 1 Baculovirus immediate-early protein (IE-0) Prok-RING_4 PF14447.6 EMD68128.1 - 0.041 13.7 10.4 0.21 11.4 8.2 2.3 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 EMD68128.1 - 0.17 11.8 10.2 0.36 10.7 10.2 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) FYDLN_acid PF09538.10 EMD68128.1 - 0.51 11.0 28.4 3.2 8.5 0.2 3.9 3 0 0 3 3 3 0 Protein of unknown function (FYDLN_acid) zf-RING_5 PF14634.6 EMD68128.1 - 1.7 8.7 13.3 3.5 7.7 13.3 1.6 1 0 0 1 1 1 0 zinc-RING finger domain Zip PF02535.22 EMD68128.1 - 3.5 6.8 10.8 1.8 7.7 7.0 2.2 2 0 0 2 2 2 0 ZIP Zinc transporter TMEM247 PF15444.6 EMD68128.1 - 3.5 7.6 9.2 4.9 7.2 7.2 2.2 2 0 0 2 2 2 0 Transmembrane protein 247 DUF2052 PF09747.9 EMD68128.1 - 3.9 7.5 27.2 0.14 12.3 15.8 3.3 3 0 0 3 3 3 0 Coiled-coil domain containing protein (DUF2052) Roughex PF06020.11 EMD68128.1 - 9.8 5.2 12.9 25 3.8 12.9 1.6 1 0 0 1 1 1 0 Drosophila roughex protein Complex1_30kDa PF00329.19 EMD68129.1 - 9.2e-45 152.2 0.0 1.2e-44 151.8 0.0 1.2 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 30 Kd subunit DUF1349 PF07081.11 EMD68130.1 - 1.6e-16 60.5 0.0 2.1e-16 60.1 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1349) DUF3361 PF11841.8 EMD68131.1 - 0.018 15.0 0.1 0.035 14.0 0.1 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3361) TRAM_LAG1_CLN8 PF03798.16 EMD68133.1 - 9.5e-52 175.6 14.1 1.4e-51 175.1 14.1 1.2 1 0 0 1 1 1 1 TLC domain Cytochrom_B561 PF03188.16 EMD68133.1 - 0.099 12.8 6.7 0.027 14.6 2.2 2.2 2 1 0 3 3 3 0 Eukaryotic cytochrome b561 Cutinase PF01083.22 EMD68134.1 - 3.2e-23 82.6 0.0 3.2e-23 82.6 0.0 2.1 2 0 0 2 2 2 1 Cutinase tRNA-synt_2b PF00587.25 EMD68136.1 - 1.9e-22 80.1 0.0 8.5e-22 78.0 0.0 1.9 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 EMD68136.1 - 4.6e-14 52.6 2.7 9.6e-14 51.5 2.7 1.6 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain DivIC PF04977.15 EMD68136.1 - 0.0021 17.8 4.1 0.35 10.7 0.3 2.5 2 0 0 2 2 2 2 Septum formation initiator DUF4407 PF14362.6 EMD68136.1 - 0.021 14.2 0.5 0.042 13.2 0.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Peptidase_S46 PF10459.9 EMD68136.1 - 0.026 13.2 1.5 0.037 12.7 1.5 1.1 1 0 0 1 1 1 0 Peptidase S46 Dynactin_p22 PF07426.11 EMD68136.1 - 0.093 12.6 0.8 0.32 10.8 0.3 2.1 2 0 0 2 2 2 0 Dynactin subunit p22 CENP-H PF05837.12 EMD68136.1 - 1.7 9.1 9.0 2.5 8.6 1.2 2.7 2 1 1 3 3 3 0 Centromere protein H (CENP-H) BTB PF00651.31 EMD68137.1 - 0.077 13.2 0.0 0.56 10.5 0.0 2.0 2 0 0 2 2 2 0 BTB/POZ domain Hydrophobin_2 PF06766.11 EMD68140.1 - 7.4e-10 38.6 8.9 1.5e-09 37.6 8.9 1.5 1 1 0 1 1 1 1 Fungal hydrophobin UQ_con PF00179.26 EMD68141.1 - 1.6e-43 147.7 0.0 1.8e-43 147.6 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EMD68141.1 - 0.083 12.6 0.0 0.16 11.7 0.0 1.8 1 1 0 1 1 1 0 Prokaryotic E2 family B DEAD PF00270.29 EMD68143.1 - 1.2e-37 129.4 0.0 6.7e-37 126.9 0.0 2.1 1 1 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EMD68143.1 - 5.7e-21 74.9 0.0 1.5e-20 73.5 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EMD68143.1 - 1.4e-19 70.1 0.0 2.5e-19 69.2 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) AAA_22 PF13401.6 EMD68143.1 - 0.11 12.8 0.3 1.2 9.4 0.0 2.6 3 0 0 3 3 3 0 AAA domain SLAC1 PF03595.17 EMD68145.1 - 7.4e-80 268.6 51.9 8.4e-80 268.4 51.9 1.0 1 0 0 1 1 1 1 Voltage-dependent anion channel PET PF06297.14 EMD68149.1 - 0.0049 17.2 0.1 3.6 8.0 0.0 2.4 2 0 0 2 2 2 2 PET Domain Se-cys_synth_N PF12390.8 EMD68149.1 - 0.043 14.0 0.1 2 8.7 0.0 2.4 2 0 0 2 2 2 0 Selenocysteine synthase N terminal DDE_1 PF03184.19 EMD68150.1 - 1.4e-08 34.6 0.0 2.6e-08 33.7 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF4407 PF14362.6 EMD68150.1 - 0.32 10.3 15.6 0.42 9.9 15.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) YabA PF06156.13 EMD68150.1 - 0.39 11.4 0.1 0.39 11.4 0.1 2.2 2 0 0 2 2 2 0 Initiation control protein YabA HTH_Tnp_Tc5 PF03221.16 EMD68151.1 - 3.3e-09 36.6 0.1 6.2e-09 35.8 0.1 1.5 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EMD68151.1 - 0.0013 18.5 0.1 0.002 17.9 0.1 1.3 1 0 0 1 1 1 1 helix-turn-helix, Psq domain Drf_GBD PF06371.13 EMD68151.1 - 0.014 15.0 0.0 0.015 14.9 0.0 1.1 1 0 0 1 1 1 0 Diaphanous GTPase-binding Domain Ribosomal_S13_N PF08069.12 EMD68151.1 - 0.024 14.7 0.0 0.042 13.9 0.0 1.4 1 0 0 1 1 1 0 Ribosomal S13/S15 N-terminal domain TnsD PF15978.5 EMD68151.1 - 0.025 13.6 0.4 0.028 13.4 0.4 1.1 1 0 0 1 1 1 0 Tn7-like transposition protein D Cdc6_C PF09079.11 EMD68151.1 - 0.045 13.7 0.0 6.9 6.7 0.0 2.4 2 0 0 2 2 2 0 CDC6, C terminal winged helix domain HTH_24 PF13412.6 EMD68151.1 - 0.067 12.8 0.1 0.57 9.8 0.0 2.2 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding DUF2721 PF11026.8 EMD68151.1 - 0.32 10.9 1.0 0.58 10.0 1.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2721) Aldose_epim PF01263.20 EMD68152.1 - 1.2e-50 172.5 0.1 1.5e-50 172.2 0.1 1.0 1 0 0 1 1 1 1 Aldose 1-epimerase Amidohydro_3 PF07969.11 EMD68154.1 - 0.00026 20.6 0.0 0.023 14.2 0.0 2.2 2 0 0 2 2 2 2 Amidohydrolase family DUF4447 PF14590.6 EMD68154.1 - 0.025 14.3 0.0 3 7.6 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4447) SWIB PF02201.18 EMD68155.1 - 1.4e-20 73.0 0.0 3.2e-20 71.8 0.0 1.7 1 0 0 1 1 1 1 SWIB/MDM2 domain Pkinase PF00069.25 EMD68156.1 - 1.2e-61 208.4 0.0 1.6e-61 208.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD68156.1 - 8.7e-32 110.4 0.0 1.2e-31 110.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMD68156.1 - 4.1e-05 23.0 0.0 6.9e-05 22.3 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EMD68156.1 - 0.00042 19.7 0.2 0.0009 18.7 0.2 1.5 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EMD68156.1 - 0.0014 17.4 0.0 0.0027 16.5 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EMD68156.1 - 0.0046 16.9 1.1 0.02 14.9 0.1 2.1 2 0 0 2 2 2 1 Phosphotransferase enzyme family Endonuc_Holl PF10107.9 EMD68156.1 - 0.096 12.5 0.2 0.46 10.3 0.0 1.9 2 0 0 2 2 2 0 Endonuclease related to archaeal Holliday junction resolvase Haspin_kinase PF12330.8 EMD68156.1 - 0.16 10.9 0.1 0.25 10.2 0.1 1.3 1 0 0 1 1 1 0 Haspin like kinase domain DUF747 PF05346.11 EMD68157.1 - 1.7e-120 402.3 9.0 2.6e-120 401.7 9.0 1.3 1 0 0 1 1 1 1 Eukaryotic membrane protein family ABC2_membrane PF01061.24 EMD68158.1 - 1.7e-91 305.3 59.2 7.7e-49 166.0 25.3 3.7 4 0 0 4 4 4 2 ABC-2 type transporter ABC_tran PF00005.27 EMD68158.1 - 6.6e-37 127.1 0.0 6.6e-17 62.3 0.0 2.6 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.12 EMD68158.1 - 4.2e-36 122.7 9.3 3.5e-31 106.9 0.9 3.5 3 0 0 3 3 3 2 CDR ABC transporter ABC_trans_N PF14510.6 EMD68158.1 - 8.5e-18 64.8 0.0 8.5e-18 64.8 0.0 2.2 2 0 0 2 2 1 1 ABC-transporter N-terminal AAA_25 PF13481.6 EMD68158.1 - 2.4e-06 27.3 0.2 0.00013 21.6 0.0 2.6 3 0 0 3 3 2 1 AAA domain AAA_16 PF13191.6 EMD68158.1 - 4.6e-06 27.1 0.1 0.0025 18.2 0.1 2.9 2 0 0 2 2 2 1 AAA ATPase domain RsgA_GTPase PF03193.16 EMD68158.1 - 5.3e-05 23.2 0.0 0.0056 16.6 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_33 PF13671.6 EMD68158.1 - 5.4e-05 23.4 0.1 0.077 13.2 0.1 2.7 2 0 0 2 2 2 2 AAA domain SMC_N PF02463.19 EMD68158.1 - 7.7e-05 22.2 0.0 0.13 11.7 0.0 3.6 3 1 0 3 3 3 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EMD68158.1 - 0.00013 21.9 0.2 0.53 10.0 0.0 2.9 2 1 1 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EMD68158.1 - 0.0004 20.1 1.7 0.02 14.7 0.2 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_18 PF13238.6 EMD68158.1 - 0.0013 19.3 0.0 0.094 13.3 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EMD68158.1 - 0.01 16.1 0.4 1.5 9.1 0.1 2.6 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 EMD68158.1 - 0.019 15.5 0.1 0.13 12.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain ABC2_membrane_3 PF12698.7 EMD68158.1 - 0.03 13.5 46.0 0.059 12.5 15.9 3.0 2 2 0 2 2 2 0 ABC-2 family transporter protein cobW PF02492.19 EMD68158.1 - 0.053 13.1 0.9 1.2 8.7 0.1 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain IstB_IS21 PF01695.17 EMD68158.1 - 0.091 12.5 0.0 12 5.6 0.0 2.5 2 0 0 2 2 2 0 IstB-like ATP binding protein NACHT PF05729.12 EMD68158.1 - 0.19 11.7 1.8 5.4 6.9 0.5 2.7 2 0 0 2 2 2 0 NACHT domain Hum_adeno_E3A PF05393.11 EMD68158.1 - 0.23 11.5 1.9 3.2 7.8 0.3 2.6 2 0 0 2 2 2 0 Human adenovirus early E3A glycoprotein AAA_24 PF13479.6 EMD68158.1 - 0.26 11.0 1.0 15 5.2 0.2 2.4 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 EMD68158.1 - 0.52 10.0 2.6 9 6.0 0.6 2.5 2 0 0 2 2 2 0 AAA domain PDR_assoc PF08370.11 EMD68158.1 - 1.3 8.9 9.3 0.14 12.0 0.4 3.4 3 0 0 3 3 3 0 Plant PDR ABC transporter associated p450 PF00067.22 EMD68161.1 - 2.5e-44 151.8 0.0 3.1e-44 151.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 MFS_1 PF07690.16 EMD68162.1 - 7.9e-20 71.1 40.9 7.9e-20 71.1 40.9 1.5 1 1 1 2 2 2 1 Major Facilitator Superfamily Gate PF07670.14 EMD68162.1 - 0.63 10.3 6.4 0.23 11.7 1.7 2.6 2 1 0 2 2 2 0 Nucleoside recognition OATP PF03137.20 EMD68162.1 - 2.3 6.4 11.2 0.86 7.8 0.2 3.1 2 1 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family UCR_hinge PF02320.16 EMD68163.1 - 6.5e-25 87.1 10.5 1.1e-24 86.4 10.5 1.4 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase hinge protein RraA-like PF03737.15 EMD68163.1 - 2.7e-23 82.8 0.4 4e-23 82.2 0.4 1.2 1 0 0 1 1 1 1 Aldolase/RraA ApbA PF02558.16 EMD68163.1 - 0.028 14.1 0.1 0.063 12.9 0.1 1.6 1 1 0 1 1 1 0 Ketopantoate reductase PanE/ApbA UDPG_MGDP_dh_N PF03721.14 EMD68163.1 - 0.068 12.7 0.1 0.11 12.1 0.1 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Sigma70_ner PF04546.13 EMD68163.1 - 0.36 10.7 5.8 0.49 10.2 5.8 1.3 1 0 0 1 1 1 0 Sigma-70, non-essential region RR_TM4-6 PF06459.12 EMD68163.1 - 0.37 10.6 7.0 0.53 10.1 7.0 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Nop14 PF04147.12 EMD68163.1 - 0.47 8.6 12.4 0.59 8.3 12.4 1.1 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.12 EMD68163.1 - 1.1 8.6 12.3 1.3 8.4 12.3 1.1 1 0 0 1 1 1 0 SDA1 Zip PF02535.22 EMD68163.1 - 1.8 7.7 5.0 2.8 7.0 5.0 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter CDC45 PF02724.14 EMD68163.1 - 2.1 6.6 7.2 8.1 4.6 7.6 1.7 2 0 0 2 2 2 0 CDC45-like protein Peptidase_M41 PF01434.18 EMD68164.1 - 1.1e-55 188.5 0.1 1.7e-55 187.8 0.1 1.3 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 EMD68164.1 - 7.6e-43 146.1 0.0 1.8e-42 144.9 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EMD68164.1 - 6.1e-09 35.5 0.0 1.3e-08 34.5 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 EMD68164.1 - 1.2e-05 25.4 0.0 5.5e-05 23.2 0.0 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) TIP49 PF06068.13 EMD68164.1 - 5.7e-05 22.5 0.0 0.00012 21.5 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_16 PF13191.6 EMD68164.1 - 8.9e-05 22.9 0.7 0.00092 19.6 0.7 2.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_25 PF13481.6 EMD68164.1 - 0.0007 19.2 0.6 0.44 10.1 0.1 2.4 1 1 1 2 2 2 2 AAA domain AAA_22 PF13401.6 EMD68164.1 - 0.00075 19.8 0.5 0.18 12.1 0.0 3.0 4 0 0 4 4 3 1 AAA domain RuvB_N PF05496.12 EMD68164.1 - 0.0052 16.5 0.0 0.011 15.5 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 EMD68164.1 - 0.019 15.1 0.0 0.06 13.5 0.0 1.9 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 EMD68164.1 - 0.022 14.5 0.0 0.051 13.3 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein Mg_chelatase PF01078.21 EMD68164.1 - 0.041 13.3 0.2 0.086 12.2 0.2 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI ATPase PF06745.13 EMD68164.1 - 0.059 12.7 0.0 1.1 8.5 0.0 2.3 2 0 0 2 2 2 0 KaiC AAA_2 PF07724.14 EMD68164.1 - 0.13 12.4 0.0 0.38 10.8 0.0 1.8 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) AAA_7 PF12775.7 EMD68164.1 - 0.16 11.4 0.1 0.57 9.7 0.1 1.8 1 1 0 1 1 1 0 P-loop containing dynein motor region bZIP_2 PF07716.15 EMD68165.1 - 5e-05 23.3 4.8 5e-05 23.3 4.8 2.2 2 0 0 2 2 2 1 Basic region leucine zipper bZIP_1 PF00170.21 EMD68165.1 - 0.0046 17.0 5.5 0.0046 17.0 5.5 1.8 2 0 0 2 2 2 1 bZIP transcription factor G-alpha PF00503.20 EMD68166.1 - 3e-45 154.9 0.2 5.8e-45 154.0 0.2 1.5 1 0 0 1 1 1 1 G-protein alpha subunit F-box-like PF12937.7 EMD68167.1 - 1.6e-07 31.1 0.0 3.1e-07 30.2 0.0 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EMD68167.1 - 0.0022 17.8 0.1 0.0047 16.8 0.1 1.5 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 EMD68167.1 - 0.12 12.2 0.1 0.26 11.2 0.1 1.5 1 0 0 1 1 1 0 F-box MFS_MOT1 PF16983.5 EMD68168.1 - 6e-57 190.8 29.4 8.7e-31 106.6 8.5 2.7 3 0 0 3 3 3 2 Molybdate transporter of MFS superfamily adh_short_C2 PF13561.6 EMD68169.1 - 4.6e-54 183.5 0.1 5.6e-54 183.2 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EMD68169.1 - 6.2e-38 130.2 0.1 1.1e-37 129.5 0.0 1.4 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.10 EMD68169.1 - 2.3e-13 50.5 0.7 3.1e-13 50.0 0.7 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EMD68169.1 - 0.014 14.9 0.3 0.08 12.4 0.3 1.9 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family DUF805 PF05656.14 EMD68169.1 - 0.099 13.1 0.1 0.25 11.8 0.1 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF805) Peptidase_S49_N PF08496.10 EMD68170.1 - 1.5 8.8 4.9 0.26 11.3 1.3 1.5 1 1 1 2 2 2 0 Peptidase family S49 N-terminal Uso1_p115_head PF04869.14 EMD68171.1 - 3.5e-105 351.6 0.0 6.4e-105 350.7 0.0 1.5 1 0 0 1 1 1 1 Uso1 / p115 like vesicle tethering protein, head region CENP-Q PF13094.6 EMD68171.1 - 0.033 14.4 3.1 0.084 13.1 3.1 1.6 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit Adaptin_N PF01602.20 EMD68171.1 - 0.095 11.2 0.4 1.7 7.1 0.1 2.7 1 1 1 2 2 2 0 Adaptin N terminal region DUF4407 PF14362.6 EMD68171.1 - 0.31 10.4 3.7 0.56 9.5 3.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) FapA PF03961.13 EMD68171.1 - 0.51 8.9 1.4 0.81 8.2 1.4 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A BST2 PF16716.5 EMD68171.1 - 2 9.1 7.8 1.9 9.1 3.2 2.5 2 0 0 2 2 2 0 Bone marrow stromal antigen 2 FlxA PF14282.6 EMD68171.1 - 2.2 8.3 7.8 0.25 11.3 3.2 1.7 2 0 0 2 2 2 0 FlxA-like protein Methyltr_RsmB-F PF01189.17 EMD68172.1 - 1.2e-35 123.0 0.0 2.2e-27 96.0 0.0 3.5 2 1 0 2 2 2 2 16S rRNA methyltransferase RsmB/F B2-adapt-app_C PF09066.10 EMD68172.1 - 0.033 14.3 0.0 0.072 13.2 0.0 1.5 1 0 0 1 1 1 0 Beta2-adaptin appendage, C-terminal sub-domain FtsJ PF01728.19 EMD68172.1 - 0.1 12.7 0.0 0.37 10.9 0.0 2.0 2 1 0 2 2 2 0 FtsJ-like methyltransferase Remorin_C PF03763.13 EMD68172.1 - 1.5 8.7 7.0 3.5 7.5 0.1 2.6 2 0 0 2 2 2 0 Remorin, C-terminal region Ribosomal_L30_N PF08079.12 EMD68173.1 - 4.2e-22 78.2 15.8 4.2e-22 78.2 15.8 1.5 2 0 0 2 2 2 1 Ribosomal L30 N-terminal domain Ribosomal_L30 PF00327.20 EMD68173.1 - 1.1e-18 66.8 2.2 1.1e-18 66.8 2.2 1.7 2 0 0 2 2 2 1 Ribosomal protein L30p/L7e CSRNP_N PF16019.5 EMD68173.1 - 0.011 15.7 3.3 0.015 15.2 3.3 1.1 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus Fungal_trans PF04082.18 EMD68174.1 - 1.4e-25 89.8 0.0 1.2e-24 86.8 0.0 2.4 2 1 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD68174.1 - 1.8e-08 34.4 11.3 2.8e-08 33.7 11.3 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.16 EMD68175.1 - 3.9e-37 128.0 25.6 4.8e-30 104.7 0.3 2.1 1 1 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EMD68175.1 - 6.1e-11 41.9 1.6 9.7e-11 41.2 0.2 2.0 2 0 0 2 2 2 1 Sugar (and other) transporter MFS_1_like PF12832.7 EMD68175.1 - 7.9e-05 21.7 4.9 7.9e-05 21.7 4.9 2.1 2 0 0 2 2 2 1 MFS_1 like family DUF2198 PF09964.9 EMD68175.1 - 0.11 12.5 0.4 0.85 9.7 0.3 2.4 2 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2198) BIRC6 PF12356.8 EMD68175.1 - 0.13 11.7 0.3 0.27 10.6 0.0 1.6 2 0 0 2 2 2 0 Baculoviral IAP repeat-containing protein 6 UQ_con PF00179.26 EMD68177.1 - 7.5e-09 35.4 0.1 1.4e-08 34.4 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EMD68177.1 - 0.15 12.4 0.1 0.27 11.5 0.1 1.4 1 0 0 1 1 1 0 RWD domain SRP-alpha_N PF04086.13 EMD68179.1 - 0.0063 16.5 11.1 0.0066 16.4 11.1 1.1 1 0 0 1 1 1 1 Signal recognition particle, alpha subunit, N-terminal DUF3807 PF12720.7 EMD68179.1 - 0.01 16.1 10.1 0.011 16.1 10.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) EOS1 PF12326.8 EMD68179.1 - 0.027 14.4 1.0 0.028 14.3 1.0 1.2 1 0 0 1 1 1 0 N-glycosylation protein HA2 PF04408.23 EMD68179.1 - 0.054 13.8 2.5 0.072 13.4 2.5 1.3 1 0 0 1 1 1 0 Helicase associated domain (HA2) DUF3292 PF11696.8 EMD68179.1 - 0.068 11.5 5.3 0.082 11.3 5.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) US2 PF02476.15 EMD68179.1 - 0.087 13.5 1.7 0.12 13.1 1.7 1.3 1 0 0 1 1 1 0 US2 family DUF3405 PF11885.8 EMD68179.1 - 0.09 11.4 3.8 0.086 11.4 3.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3405) YqfQ PF14181.6 EMD68179.1 - 0.23 11.7 10.7 0.25 11.5 10.7 1.1 1 0 0 1 1 1 0 YqfQ-like protein CLN3 PF02487.17 EMD68179.1 - 0.25 10.3 2.0 0.36 9.8 2.0 1.2 1 0 0 1 1 1 0 CLN3 protein FAM176 PF14851.6 EMD68179.1 - 0.33 10.6 2.3 0.51 10.0 2.3 1.2 1 0 0 1 1 1 0 FAM176 family Presenilin PF01080.17 EMD68179.1 - 0.34 9.6 3.1 0.38 9.5 3.1 1.1 1 0 0 1 1 1 0 Presenilin Eapp_C PF10238.9 EMD68179.1 - 0.41 10.7 8.9 0.54 10.3 8.9 1.2 1 0 0 1 1 1 0 E2F-associated phosphoprotein NARP1 PF12569.8 EMD68179.1 - 0.43 9.4 16.8 0.44 9.4 16.8 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 G0-G1_switch_2 PF15103.6 EMD68179.1 - 0.59 10.6 9.2 0.76 10.2 9.2 1.2 1 0 0 1 1 1 0 G0/G1 switch protein 2 EIIBC-GUT_N PF03612.14 EMD68179.1 - 0.72 9.6 8.6 0.92 9.2 8.6 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Folate_carrier PF01770.18 EMD68179.1 - 0.83 8.3 5.6 1 8.0 5.6 1.1 1 0 0 1 1 1 0 Reduced folate carrier Peroxin-13_N PF04088.13 EMD68179.1 - 1.4 9.2 4.6 1.8 8.8 4.6 1.2 1 0 0 1 1 1 0 Peroxin 13, N-terminal region TMEM214 PF10151.9 EMD68179.1 - 1.5 7.2 15.0 1.6 7.1 15.0 1.1 1 0 0 1 1 1 0 TMEM214, C-terminal, caspase 4 activator PPL5 PF18168.1 EMD68179.1 - 2.3 7.5 9.5 2.8 7.1 9.5 1.1 1 0 0 1 1 1 0 Prim-pol family 5 OATP PF03137.20 EMD68179.1 - 2.6 6.2 7.0 3.2 5.9 7.0 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family YMF19 PF02326.15 EMD68179.1 - 2.7 8.8 6.5 5.5 7.8 6.5 1.5 1 0 0 1 1 1 0 Plant ATP synthase F0 DDHD PF02862.17 EMD68179.1 - 3.6 7.7 9.3 5.4 7.1 9.3 1.3 1 1 0 1 1 1 0 DDHD domain Ureide_permease PF07168.11 EMD68179.1 - 8.3 5.0 5.0 10 4.7 5.0 1.1 1 0 0 1 1 1 0 Ureide permease Tmemb_161AB PF10268.9 EMD68179.1 - 8.6 4.9 6.4 11 4.5 6.4 1.2 1 0 0 1 1 1 0 Predicted transmembrane protein 161AB Jak1_Phl PF17887.1 EMD68179.1 - 9.7 6.1 15.1 14 5.6 15.1 1.2 1 0 0 1 1 1 0 Jak1 pleckstrin homology-like domain adh_short PF00106.25 EMD68181.1 - 3.6e-37 127.7 0.1 5e-37 127.2 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD68181.1 - 2.6e-24 86.1 0.1 3.7e-24 85.6 0.1 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD68181.1 - 6.6e-08 32.7 0.6 1.8e-07 31.3 0.6 1.6 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 EMD68181.1 - 0.00024 20.6 0.0 0.00039 20.0 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EMD68181.1 - 0.00072 18.6 0.1 0.0011 18.1 0.1 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family DUF1776 PF08643.10 EMD68181.1 - 0.0072 15.7 0.0 0.011 15.1 0.0 1.3 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) DUF3216 PF11505.8 EMD68181.1 - 0.18 12.1 0.0 0.32 11.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3216) GTP1_OBG PF01018.22 EMD68182.1 - 6.7e-40 136.2 1.9 3.2e-29 101.5 3.5 2.3 2 0 0 2 2 2 2 GTP1/OBG MMR_HSR1 PF01926.23 EMD68182.1 - 2.3e-23 82.4 0.0 3.7e-23 81.8 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EMD68182.1 - 2e-07 30.7 0.4 4.2e-07 29.6 0.1 1.8 2 1 0 2 2 2 1 Ferrous iron transport protein B Arf PF00025.21 EMD68182.1 - 0.011 15.2 0.0 0.081 12.4 0.0 2.1 2 0 0 2 2 2 0 ADP-ribosylation factor family MeaB PF03308.16 EMD68182.1 - 0.036 13.0 0.0 1.6 7.6 0.0 2.3 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_18 PF13238.6 EMD68182.1 - 0.039 14.5 0.0 0.096 13.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain GTP_EFTU PF00009.27 EMD68182.1 - 0.079 12.5 0.0 2.6 7.5 0.0 2.2 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain Med26_M PF15694.5 EMD68182.1 - 8.6 6.3 7.5 12 5.8 5.6 1.8 1 1 0 2 2 2 0 Mediator complex subunit 26 middle domain Epimerase PF01370.21 EMD68184.1 - 2.2e-20 73.2 0.0 2.8e-20 72.8 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EMD68184.1 - 1e-15 57.5 0.0 1.2e-15 57.3 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 EMD68184.1 - 3.4e-13 49.7 0.0 7.9e-13 48.5 0.0 1.9 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 EMD68184.1 - 3.6e-08 32.9 0.0 9.5e-08 31.5 0.0 1.6 1 1 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.12 EMD68184.1 - 1.7e-06 27.4 0.1 0.00021 20.6 0.1 2.5 1 1 0 1 1 1 1 Male sterility protein Ldh_1_N PF00056.23 EMD68184.1 - 1.5e-05 25.1 0.0 2.4e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain NAD_binding_10 PF13460.6 EMD68184.1 - 6.2e-05 23.0 0.0 0.00012 22.0 0.0 1.5 2 0 0 2 2 2 1 NAD(P)H-binding KR PF08659.10 EMD68184.1 - 0.0032 17.4 0.0 0.026 14.4 0.0 2.2 1 1 1 2 2 2 1 KR domain Polysacc_synt_2 PF02719.15 EMD68184.1 - 0.018 14.2 0.0 0.22 10.7 0.0 2.0 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein MMR_HSR1 PF01926.23 EMD68185.1 - 6.2e-16 58.5 0.0 1e-15 57.8 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 EMD68185.1 - 1e-05 25.7 0.1 0.016 15.3 0.1 2.4 2 0 0 2 2 2 2 Dynamin family FeoB_N PF02421.18 EMD68185.1 - 0.00043 19.8 0.0 0.029 13.9 0.0 2.2 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EMD68185.1 - 0.00094 19.1 0.1 0.0093 15.9 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 EMD68185.1 - 0.0043 16.6 0.0 0.013 15.1 0.0 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Roc PF08477.13 EMD68185.1 - 0.017 15.4 0.0 0.031 14.5 0.0 1.4 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Septin PF00735.18 EMD68185.1 - 0.051 12.8 0.0 0.1 11.9 0.0 1.5 1 1 0 1 1 1 0 Septin ALGX PF16822.5 EMD68185.1 - 0.17 11.6 0.0 0.25 11.0 0.0 1.2 1 0 0 1 1 1 0 SGNH hydrolase-like domain, acetyltransferase AlgX Complex1_LYR_2 PF13233.6 EMD68186.1 - 9.8e-22 77.5 0.5 1.2e-21 77.2 0.5 1.1 1 0 0 1 1 1 1 Complex1_LYR-like Terminase_4 PF05119.12 EMD68186.1 - 0.014 15.8 0.1 0.02 15.3 0.1 1.2 1 0 0 1 1 1 0 Phage terminase, small subunit Complex1_LYR PF05347.15 EMD68186.1 - 0.083 13.0 1.1 0.18 11.9 1.1 1.7 1 1 0 1 1 1 0 Complex 1 protein (LYR family) SRP40_C PF05022.12 EMD68187.1 - 1.7e-20 73.6 0.9 1.7e-20 73.6 0.9 2.9 2 0 0 2 2 2 1 SRP40, C-terminal domain Sec3_C PF09763.9 EMD68188.1 - 1.5e-214 714.5 0.3 1.9e-214 714.1 0.3 1.1 1 0 0 1 1 1 1 Exocyst complex component Sec3 Sec3-PIP2_bind PF15277.6 EMD68188.1 - 6.2e-27 93.6 0.0 1.1e-26 92.8 0.0 1.4 1 0 0 1 1 1 1 Exocyst complex component SEC3 N-terminal PIP2 binding PH Vps52 PF04129.12 EMD68188.1 - 0.00082 18.2 0.4 0.0015 17.3 0.4 1.3 1 0 0 1 1 1 1 Vps52 / Sac2 family Sec3_C_2 PF15278.6 EMD68188.1 - 0.01 16.1 0.2 0.025 14.9 0.2 1.6 1 0 0 1 1 1 0 Sec3 exocyst complex subunit Sec34 PF04136.15 EMD68188.1 - 0.29 11.0 0.9 0.88 9.4 0.9 1.8 1 0 0 1 1 1 0 Sec34-like family Cep57_MT_bd PF06657.13 EMD68188.1 - 5.1 7.6 5.3 2.7 8.5 0.6 2.8 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 DUF1295 PF06966.12 EMD68189.1 - 3.3e-41 141.3 0.6 1.9e-39 135.6 0.6 2.2 1 1 0 1 1 1 1 Protein of unknown function (DUF1295) ICMT PF04140.14 EMD68189.1 - 0.0017 18.7 0.0 0.0058 17.0 0.0 1.9 2 0 0 2 2 2 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family Steroid_dh PF02544.16 EMD68189.1 - 0.0049 16.9 0.0 0.0089 16.0 0.0 1.4 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase PNTB PF02233.16 EMD68189.1 - 0.013 14.5 0.0 0.02 13.9 0.0 1.3 1 0 0 1 1 1 0 NAD(P) transhydrogenase beta subunit PEMT PF04191.13 EMD68189.1 - 0.024 15.0 0.6 0.11 12.9 0.0 2.4 2 1 1 3 3 3 0 Phospholipid methyltransferase ERG4_ERG24 PF01222.17 EMD68189.1 - 0.091 11.5 0.0 0.17 10.6 0.0 1.4 1 1 0 1 1 1 0 Ergosterol biosynthesis ERG4/ERG24 family MFS_1 PF07690.16 EMD68190.1 - 5.5e-36 124.2 30.5 7.7e-36 123.7 30.5 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily TT_ORF2 PF02957.15 EMD68191.1 - 3.5 8.6 5.4 9.6 7.2 0.2 3.6 3 0 0 3 3 3 0 TT viral ORF2 Aha1_N PF09229.11 EMD68192.1 - 3.1e-39 134.3 1.6 5e-39 133.6 1.6 1.3 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal AHSA1 PF08327.11 EMD68192.1 - 1.2e-18 67.5 0.6 1.2e-18 67.5 0.6 1.5 2 0 0 2 2 2 1 Activator of Hsp90 ATPase homolog 1-like protein Pox_A12 PF04651.13 EMD68192.1 - 0.037 14.1 3.7 0.069 13.2 1.6 2.0 2 0 0 2 2 2 0 Poxvirus A12 protein MFS_1 PF07690.16 EMD68193.1 - 4.5e-29 101.5 28.8 4.5e-29 101.5 28.8 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EMD68193.1 - 1.3e-09 37.5 20.1 1.9e-09 36.9 20.1 1.3 1 0 0 1 1 1 1 Sugar (and other) transporter Aminotran_1_2 PF00155.21 EMD68195.1 - 1.5e-36 126.3 0.0 1.7e-36 126.2 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II V_ATPase_I PF01496.19 EMD68196.1 - 0 1046.0 0.0 0 1045.8 0.0 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family Filament PF00038.21 EMD68196.1 - 0.0017 18.0 2.3 0.69 9.4 0.2 2.2 2 0 0 2 2 2 2 Intermediate filament protein CheZ PF04344.13 EMD68196.1 - 0.012 15.5 2.6 0.044 13.7 0.2 2.3 2 0 0 2 2 2 0 Chemotaxis phosphatase, CheZ THP2 PF09432.10 EMD68196.1 - 0.032 14.3 0.3 0.11 12.5 0.3 1.9 1 0 0 1 1 1 0 Tho complex subunit THP2 Baculo_PEP_C PF04513.12 EMD68196.1 - 0.095 12.7 0.7 0.76 9.8 0.1 2.3 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus BLOC1_2 PF10046.9 EMD68196.1 - 0.43 10.9 1.8 1.9 8.8 0.2 2.5 2 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF1664 PF07889.12 EMD68196.1 - 0.46 10.5 2.2 5.8 7.0 0.2 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) FapA PF03961.13 EMD68196.1 - 0.85 8.2 2.6 0.76 8.3 0.1 1.8 2 0 0 2 2 2 0 Flagellar Assembly Protein A DASH_Dam1 PF08653.10 EMD68196.1 - 5.2 7.0 6.9 13 5.7 0.1 4.6 6 0 0 6 6 6 0 DASH complex subunit Dam1 Btz PF09405.10 EMD68197.1 - 2.2e-27 95.9 2.7 6.1e-27 94.4 2.7 1.8 1 0 0 1 1 1 1 CASC3/Barentsz eIF4AIII binding DUF4193 PF13834.6 EMD68197.1 - 0.17 12.4 4.3 0.38 11.3 4.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4193) TFIIF_alpha PF05793.12 EMD68197.1 - 0.49 8.9 7.3 0.75 8.3 7.3 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) zf_CCCH_4 PF18345.1 EMD68198.1 - 9.3e-07 28.7 5.8 1.6e-06 28.0 5.8 1.4 1 0 0 1 1 1 1 Zinc finger domain Torus PF16131.5 EMD68198.1 - 4.5e-06 27.3 0.8 1.3e-05 25.8 0.8 1.8 1 0 0 1 1 1 1 Torus domain zf-CCCH_4 PF18044.1 EMD68198.1 - 6.4e-06 25.8 2.9 1.1e-05 25.1 2.9 1.4 1 0 0 1 1 1 1 CCCH-type zinc finger zf-CCCH PF00642.24 EMD68198.1 - 8.3e-06 25.6 0.5 1.5e-05 24.8 0.5 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.6 EMD68198.1 - 0.033 14.7 3.9 0.059 13.9 3.9 1.4 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger zf-CCCH_3 PF15663.5 EMD68198.1 - 0.06 13.6 0.5 0.16 12.2 0.5 1.7 1 0 0 1 1 1 0 Zinc-finger containing family CaiF_GrlA PF07180.11 EMD68198.1 - 0.11 12.5 0.1 0.36 10.8 0.0 1.9 2 0 0 2 2 2 0 CaiF/GrlA transcriptional regulator Ribosomal_L22 PF00237.19 EMD68198.1 - 1.3 9.3 8.4 8.4 6.7 0.2 3.2 3 0 0 3 3 3 0 Ribosomal protein L22p/L17e Sec1 PF00995.23 EMD68199.1 - 3.6e-107 360.0 0.0 4.1e-107 359.8 0.0 1.0 1 0 0 1 1 1 1 Sec1 family Nucleo_P87 PF07267.11 EMD68200.1 - 0.34 9.7 6.1 0.37 9.6 6.1 1.0 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 HET PF06985.11 EMD68201.1 - 7.8e-17 62.0 0.0 1.3e-16 61.3 0.0 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Usp PF00582.26 EMD68202.1 - 3e-20 73.2 1.8 2.8e-19 70.0 0.6 2.7 2 1 0 2 2 2 1 Universal stress protein family Ribosomal_S7 PF00177.21 EMD68203.1 - 3.1e-29 101.6 0.0 4.9e-29 100.9 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e Baculo_PEP_C PF04513.12 EMD68204.1 - 0.08 13.0 3.9 4.8 7.2 0.0 3.1 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Exonuc_VII_L PF02601.15 EMD68204.1 - 0.63 9.6 4.0 1 8.8 4.0 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Glyco_hydro_88 PF07470.13 EMD68205.1 - 2.3e-10 40.1 0.1 3.3e-10 39.6 0.1 1.2 1 0 0 1 1 1 1 Glycosyl Hydrolase Family 88 Cellulase PF00150.18 EMD68206.1 - 6.1e-12 45.5 6.0 1.2e-10 41.3 6.0 2.5 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) MFS_1 PF07690.16 EMD68207.1 - 7e-21 74.5 23.3 1.9e-20 73.1 23.3 1.7 1 1 0 1 1 1 1 Major Facilitator Superfamily adh_short_C2 PF13561.6 EMD68208.1 - 4.2e-46 157.4 0.1 4.9e-46 157.2 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EMD68208.1 - 6.4e-34 117.1 0.1 8.2e-34 116.8 0.1 1.0 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EMD68208.1 - 1.7e-08 34.6 0.2 2.3e-08 34.2 0.2 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EMD68208.1 - 0.015 14.8 0.0 0.019 14.4 0.0 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family CcmE PF03100.15 EMD68208.1 - 0.022 14.7 0.0 0.039 14.0 0.0 1.3 1 0 0 1 1 1 0 CcmE Phage_GPD PF05954.11 EMD68208.1 - 0.1 11.8 0.0 0.15 11.4 0.0 1.2 1 0 0 1 1 1 0 Phage late control gene D protein (GPD) EMP24_GP25L PF01105.24 EMD68209.1 - 2.3e-42 145.0 0.0 2.8e-42 144.7 0.0 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD EzrA PF06160.12 EMD68209.1 - 0.2 9.8 0.1 0.27 9.4 0.1 1.1 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA Tyrosinase PF00264.20 EMD68210.1 - 7.4e-49 167.0 0.1 1.6e-48 165.9 0.1 1.6 1 0 0 1 1 1 1 Common central domain of tyrosinase Tyosinase_C PF18132.1 EMD68210.1 - 2.3e-21 76.7 0.0 4.1e-21 75.9 0.0 1.4 1 0 0 1 1 1 1 Tyosinase C-terminal domain MSA-2c PF12238.8 EMD68210.1 - 2.7 7.9 7.1 6.6 6.7 7.1 1.6 1 0 0 1 1 1 0 Merozoite surface antigen 2c Methyltransf_25 PF13649.6 EMD68211.1 - 2e-09 38.0 0.0 9.9e-09 35.8 0.0 2.0 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMD68211.1 - 7.9e-08 32.8 0.0 1.2e-06 29.0 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMD68211.1 - 1.7e-07 31.2 0.0 2.3e-07 30.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMD68211.1 - 3.8e-05 24.4 0.0 9e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EMD68211.1 - 0.0002 21.2 0.0 0.00026 20.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain TehB PF03848.14 EMD68211.1 - 0.017 14.5 0.0 0.028 13.8 0.0 1.3 1 0 0 1 1 1 0 Tellurite resistance protein TehB 3HCDH_N PF02737.18 EMD68211.1 - 0.055 13.3 0.1 0.12 12.3 0.1 1.6 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain MTS PF05175.14 EMD68211.1 - 0.095 12.3 0.0 0.14 11.6 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_9 PF08003.11 EMD68211.1 - 0.13 11.1 0.0 0.17 10.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) SNF2_N PF00176.23 EMD68212.1 - 3.3e-62 210.2 0.0 6.3e-61 206.0 0.0 2.6 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EMD68212.1 - 6e-17 62.0 0.1 1.9e-16 60.4 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EMD68212.1 - 5.3e-05 23.3 0.0 5.3e-05 23.3 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Pox_Ag35 PF03286.14 EMD68212.1 - 5.9 6.6 36.3 0.39 10.5 14.2 3.7 3 0 0 3 3 3 0 Pox virus Ag35 surface protein Lipase_3 PF01764.25 EMD68213.1 - 3.2e-27 95.1 0.0 4.8e-27 94.6 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) Hydrolase_4 PF12146.8 EMD68213.1 - 0.0021 17.3 0.0 0.0054 16.0 0.0 1.5 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EMD68213.1 - 0.0027 18.3 1.2 0.0027 18.3 1.2 2.0 1 1 1 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EMD68213.1 - 0.15 11.7 0.0 0.24 11.0 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold DUF1691 PF07950.11 EMD68215.1 - 0.026 15.3 0.6 0.033 14.9 0.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1691) Peptidase_S8 PF00082.22 EMD68216.1 - 2.1e-34 119.2 13.5 4.8e-34 118.0 13.5 1.5 1 1 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 EMD68216.1 - 1.1e-07 32.4 0.0 5.8e-07 30.1 0.0 2.2 1 1 0 1 1 1 1 Peptidase inhibitor I9 Peptidase_S8 PF00082.22 EMD68217.1 - 1e-27 97.2 2.4 8.3e-27 94.2 2.4 2.0 1 1 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 EMD68217.1 - 6.5e-06 26.7 0.0 1.5e-05 25.6 0.0 1.6 1 1 0 1 1 1 1 Peptidase inhibitor I9 Cytochrom_C PF00034.21 EMD68218.1 - 9.6 7.4 18.0 6 8.1 0.1 5.9 3 3 0 5 5 5 0 Cytochrome c COesterase PF00135.28 EMD68219.1 - 5.9e-63 213.5 0.0 1.5e-62 212.1 0.0 1.5 1 1 0 1 1 1 1 Carboxylesterase family Peptidase_S9 PF00326.21 EMD68219.1 - 0.00011 21.7 0.7 0.00066 19.2 1.3 2.0 2 1 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_3 PF07859.13 EMD68219.1 - 0.00018 21.4 0.1 0.00053 19.9 0.0 1.8 2 0 0 2 2 2 1 alpha/beta hydrolase fold DUF1749 PF08538.10 EMD68219.1 - 0.0049 16.0 0.0 0.0098 15.0 0.0 1.4 2 0 0 2 2 2 1 Protein of unknown function (DUF1749) Abhydrolase_6 PF12697.7 EMD68219.1 - 0.0084 16.7 0.0 0.017 15.8 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF1180 PF06679.12 EMD68220.1 - 0.18 12.2 2.7 0.24 11.8 2.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Zn_clus PF00172.18 EMD68221.1 - 2.2e-09 37.3 12.5 3.3e-09 36.7 12.5 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SasG_E PF17041.5 EMD68221.1 - 0.019 14.9 0.2 0.042 13.8 0.2 1.5 1 0 0 1 1 1 0 E domain Copper-fist PF00649.18 EMD68222.1 - 2.9e-20 71.5 2.3 2.9e-20 71.5 2.3 2.0 2 0 0 2 2 2 1 Copper fist DNA binding domain WD40 PF00400.32 EMD68228.1 - 8.5e-56 184.7 23.8 8.5e-10 39.1 0.5 8.4 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD68228.1 - 3.2e-14 53.0 0.0 4.5e-05 23.7 0.0 4.9 4 1 1 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EMD68228.1 - 1.8e-07 30.2 0.0 0.00034 19.4 0.0 3.5 4 0 0 4 4 4 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 EMD68228.1 - 5.7e-06 25.3 0.2 0.45 9.2 0.0 3.2 3 0 0 3 3 3 3 Nup133 N terminal like bZIP_1 PF00170.21 EMD68228.1 - 0.033 14.3 0.6 0.061 13.4 0.6 1.3 1 0 0 1 1 1 0 bZIP transcription factor Cytochrom_D1 PF02239.16 EMD68228.1 - 0.1 11.1 0.1 6.6 5.2 0.0 2.1 2 0 0 2 2 2 0 Cytochrome D1 heme domain Cnd1 PF12717.7 EMD68229.1 - 1.5e-06 28.3 0.1 0.012 15.7 0.1 2.5 2 0 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.8 EMD68229.1 - 1.7e-06 27.8 1.7 0.00019 21.1 0.7 2.7 2 1 1 3 3 3 1 CLASP N terminal Adaptin_N PF01602.20 EMD68229.1 - 2.8e-05 22.9 2.0 0.00042 19.0 1.9 2.6 1 1 0 1 1 1 1 Adaptin N terminal region HEAT_2 PF13646.6 EMD68229.1 - 3.6e-05 24.1 2.7 0.2 12.1 0.0 4.4 3 1 2 5 5 5 1 HEAT repeats HEAT PF02985.22 EMD68229.1 - 0.00011 22.1 0.8 14 6.2 0.1 5.4 5 0 0 5 5 5 0 HEAT repeat ATG16 PF08614.11 EMD68229.1 - 0.004 17.4 1.8 0.004 17.4 1.8 2.9 3 0 0 3 3 3 1 Autophagy protein 16 (ATG16) HALZ PF02183.18 EMD68229.1 - 0.011 15.9 1.0 0.04 14.1 1.0 2.0 1 0 0 1 1 1 0 Homeobox associated leucine zipper TAN PF11640.8 EMD68229.1 - 0.02 15.0 1.5 0.065 13.4 1.5 1.9 1 0 0 1 1 1 0 Telomere-length maintenance and DNA damage repair MMS19_N PF14500.6 EMD68229.1 - 0.045 13.3 3.4 2.3 7.7 0.2 3.6 2 2 2 4 4 4 0 Dos2-interacting transcription regulator of RNA-Pol-II HEAT_EZ PF13513.6 EMD68229.1 - 0.15 12.6 0.6 68 4.1 0.0 4.6 3 2 1 4 4 4 0 HEAT-like repeat DivIC PF04977.15 EMD68229.1 - 0.15 11.8 10.3 0.17 11.6 5.5 2.9 1 1 1 2 2 2 0 Septum formation initiator p25-alpha PF05517.12 EMD68229.1 - 0.25 11.5 3.4 1 9.5 0.0 2.9 2 1 1 3 3 3 0 p25-alpha Atg14 PF10186.9 EMD68229.1 - 2.4 7.2 7.9 1 8.4 4.7 2.0 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF5082 PF16888.5 EMD68229.1 - 2.5 8.4 8.2 6.6 7.0 4.7 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) Jnk-SapK_ap_N PF09744.9 EMD68229.1 - 2.9 8.1 12.8 13 6.0 12.0 2.6 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 SKA2 PF16740.5 EMD68229.1 - 3.5 7.5 8.2 3.2 7.6 2.2 3.4 2 1 1 3 3 3 0 Spindle and kinetochore-associated protein 2 Sec34 PF04136.15 EMD68229.1 - 4.7 7.1 6.7 1.3 8.9 1.3 2.7 2 1 1 3 3 3 0 Sec34-like family Aminotran_1_2 PF00155.21 EMD68230.1 - 1.9e-36 126.0 0.0 2.5e-36 125.6 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II DHBP_synthase PF00926.19 EMD68231.1 - 9.1e-80 266.7 0.0 1.1e-79 266.5 0.0 1.1 1 0 0 1 1 1 1 3,4-dihydroxy-2-butanone 4-phosphate synthase Xan_ur_permease PF00860.20 EMD68232.1 - 1.1e-23 83.6 33.0 1e-22 80.4 30.6 2.7 2 1 0 2 2 2 1 Permease family DUF4956 PF16316.5 EMD68232.1 - 1.4 8.6 9.6 0.64 9.7 0.2 3.5 2 1 1 3 3 3 0 Domain of unknown function (DUF4956) MCU PF04678.13 EMD68233.1 - 3e-27 95.9 0.5 3e-27 95.9 0.5 2.0 2 0 0 2 2 2 1 Mitochondrial calcium uniporter DUF1281 PF06924.11 EMD68233.1 - 0.17 11.4 1.6 0.37 10.3 1.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1281) DUF5093 PF17011.5 EMD68233.1 - 2.4 8.4 7.2 5.8 7.2 7.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5093) RRM_1 PF00076.22 EMD68235.1 - 2.1e-80 264.5 4.3 1.8e-19 69.3 0.1 5.4 5 0 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.18 EMD68235.1 - 4.2e-27 94.1 0.5 4.2e-27 94.1 0.5 2.8 3 1 0 3 3 3 1 Poly-adenylate binding protein, unique domain RRM_5 PF13893.6 EMD68235.1 - 2.1e-10 40.3 1.2 0.0048 16.5 0.0 4.6 2 1 2 5 5 5 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EMD68235.1 - 0.00021 21.3 0.1 9 6.5 0.0 5.3 5 1 0 5 5 5 1 RNA recognition motif RRM_occluded PF16842.5 EMD68235.1 - 0.00031 20.6 0.1 0.7 9.8 0.0 3.8 3 0 0 3 3 3 1 Occluded RNA-recognition motif CbiG_mid PF11761.8 EMD68235.1 - 0.0035 17.4 0.0 23 5.2 0.0 3.5 3 0 0 3 3 3 0 Cobalamin biosynthesis central region YflT PF11181.8 EMD68235.1 - 0.0041 17.6 1.6 1.8 9.2 0.3 2.8 2 0 0 2 2 2 2 Heat induced stress protein YflT Nup35_RRM_2 PF14605.6 EMD68235.1 - 0.0097 15.9 0.5 37 4.4 0.0 4.1 4 0 0 4 4 4 0 Nup53/35/40-type RNA recognition motif OB_RNB PF08206.11 EMD68235.1 - 0.039 13.7 1.5 17 5.2 0.0 3.6 3 0 0 3 3 3 0 Ribonuclease B OB domain DbpA PF03880.15 EMD68235.1 - 0.14 12.2 0.1 56 3.8 0.0 3.6 4 0 0 4 4 4 0 DbpA RNA binding domain FBPase PF00316.20 EMD68236.1 - 6.3e-69 231.2 0.1 8.8e-69 230.8 0.1 1.2 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain Transket_pyr PF02779.24 EMD68237.1 - 1.8e-64 216.7 0.0 3.8e-64 215.6 0.0 1.6 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain OxoGdeHyase_C PF16870.5 EMD68237.1 - 1.3e-58 197.0 0.0 2.2e-58 196.3 0.0 1.4 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase C-terminal E1_dh PF00676.20 EMD68237.1 - 1.5e-56 191.5 0.0 2.5e-56 190.8 0.0 1.3 1 0 0 1 1 1 1 Dehydrogenase E1 component 2-oxogl_dehyd_N PF16078.5 EMD68237.1 - 1.6e-17 62.8 2.4 2.9e-17 62.0 2.4 1.4 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase N-terminus BSD PF03909.17 EMD68238.1 - 8.6e-27 92.9 3.6 2e-13 50.1 0.0 3.8 4 0 0 4 4 4 2 BSD domain PH_TFIIH PF08567.11 EMD68238.1 - 2.7e-19 69.3 0.0 6.7e-19 68.0 0.0 1.8 1 0 0 1 1 1 1 TFIIH p62 subunit, N-terminal domain Proteasome_A_N PF10584.9 EMD68240.1 - 0.21 11.3 0.1 0.51 10.1 0.1 1.6 1 0 0 1 1 1 0 Proteasome subunit A N-terminal signature DUF1992 PF09350.10 EMD68241.1 - 1.6e-20 73.0 0.2 3.5e-20 71.9 0.2 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1992) RRF PF01765.19 EMD68243.1 - 3e-30 105.3 0.1 4e-30 104.9 0.1 1.2 1 0 0 1 1 1 1 Ribosome recycling factor Mito_fiss_reg PF05308.11 EMD68243.1 - 0.071 13.2 4.1 1.2 9.2 0.4 2.3 2 1 0 2 2 2 0 Mitochondrial fission regulator DUF3176 PF11374.8 EMD68246.1 - 6.3e-30 103.5 1.2 1.8e-29 102.0 1.2 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF3176) COX2-transmemb PF09125.10 EMD68246.1 - 0.017 14.9 0.7 0.036 13.9 0.7 1.5 1 0 0 1 1 1 0 Cytochrome C oxidase subunit II, transmembrane SUR7 PF06687.12 EMD68246.1 - 0.032 13.8 0.0 0.75 9.4 0.0 2.3 2 0 0 2 2 2 0 SUR7/PalI family DUF2569 PF10754.9 EMD68246.1 - 0.06 13.8 6.4 1.1 9.7 0.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2569) DUF3176 PF11374.8 EMD68248.1 - 5e-35 120.0 2.1 5.2e-35 119.9 0.7 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF3176) DUF3153 PF11353.8 EMD68248.1 - 0.52 9.8 1.8 28 4.2 0.3 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3153) Sugar_tr PF00083.24 EMD68249.1 - 1.5e-76 258.1 8.9 1.8e-76 257.8 8.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD68249.1 - 5.1e-33 114.5 12.5 4.8e-29 101.4 6.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EMD68249.1 - 1.3e-05 23.9 7.8 0.00011 20.9 2.0 2.4 2 0 0 2 2 2 2 MFS/sugar transport protein LacY_symp PF01306.19 EMD68249.1 - 0.00021 20.2 0.7 0.00043 19.2 0.7 1.5 1 0 0 1 1 1 1 LacY proton/sugar symporter TRI12 PF06609.13 EMD68249.1 - 0.016 13.6 2.3 0.019 13.4 1.3 1.5 2 0 0 2 2 2 0 Fungal trichothecene efflux pump (TRI12) OATP PF03137.20 EMD68249.1 - 0.47 8.7 8.2 0.19 10.0 1.7 2.7 2 1 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family IlvN PF07991.12 EMD68250.1 - 4.9e-48 162.8 0.0 9.9e-48 161.8 0.0 1.5 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain IlvC PF01450.19 EMD68250.1 - 8e-40 136.4 0.0 1.2e-39 135.8 0.0 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain F420_oxidored PF03807.17 EMD68250.1 - 0.051 14.2 0.2 0.23 12.1 0.0 2.2 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 EMD68250.1 - 0.075 13.2 0.0 0.2 11.8 0.0 1.7 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase UQ_con PF00179.26 EMD68251.1 - 4.9e-39 133.2 0.0 6.8e-39 132.7 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RibD_C PF01872.17 EMD68252.1 - 4.9e-34 117.9 0.0 5.8e-34 117.7 0.0 1.1 1 0 0 1 1 1 1 RibD C-terminal domain DUF218 PF02698.17 EMD68253.1 - 0.00065 19.7 0.0 0.00099 19.1 0.0 1.3 1 0 0 1 1 1 1 DUF218 domain Chitin_synth_1 PF01644.17 EMD68255.1 - 6.8e-68 227.8 0.0 1e-67 227.2 0.0 1.3 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.11 EMD68255.1 - 3.9e-29 100.4 0.0 1.2e-28 98.9 0.0 1.8 2 0 0 2 2 2 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.15 EMD68255.1 - 1.5e-23 83.2 0.0 4.1e-19 68.6 0.0 2.2 2 0 0 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.6 EMD68255.1 - 7.1e-09 35.9 0.1 7.1e-09 35.9 0.1 2.8 4 1 0 4 4 4 1 Glycosyl transferase family group 2 DUF2264 PF10022.9 EMD68256.1 - 2.1e-135 451.4 0.6 2.1e-135 451.4 0.6 1.5 2 0 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2264) Fungal_trans PF04082.18 EMD68257.1 - 7.4e-13 48.1 0.8 2e-12 46.7 0.8 1.7 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-RING_2 PF13639.6 EMD68258.1 - 4.9e-07 30.0 9.2 5.3e-07 29.9 7.8 1.8 2 0 0 2 2 2 1 Ring finger domain zf-rbx1 PF12678.7 EMD68258.1 - 1e-05 25.7 8.6 1.9e-05 24.8 8.6 1.7 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 EMD68258.1 - 0.0005 19.9 6.5 0.00088 19.1 5.8 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EMD68258.1 - 0.0015 18.4 3.9 0.0015 18.4 3.9 1.7 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 EMD68258.1 - 0.01 15.6 8.9 0.01 15.6 8.9 1.9 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EMD68258.1 - 0.013 15.3 6.4 0.013 15.3 6.4 1.9 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 EMD68258.1 - 0.058 13.4 6.1 0.067 13.2 4.7 1.7 1 1 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-P11 PF03854.14 EMD68258.1 - 0.14 11.9 8.3 0.29 10.8 8.3 1.5 1 0 0 1 1 1 0 P-11 zinc finger Hexapep PF00132.24 EMD68259.1 - 3.2e-09 36.2 9.7 0.0011 18.6 2.5 4.0 3 1 1 4 4 4 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 EMD68259.1 - 1.1e-05 25.1 5.4 0.05 13.4 0.1 3.6 3 0 0 3 3 3 3 Hexapeptide repeat of succinyl-transferase Fucokinase PF07959.12 EMD68259.1 - 0.1 11.5 0.1 0.24 10.3 0.1 1.6 1 1 1 2 2 2 0 L-fucokinase SAPS PF04499.15 EMD68261.1 - 8.5e-188 625.1 0.0 2.6e-187 623.5 0.0 1.8 2 0 0 2 2 2 1 SIT4 phosphatase-associated protein Arm PF00514.23 EMD68261.1 - 0.12 12.4 0.0 11 6.2 0.0 3.4 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat Snf7 PF03357.21 EMD68262.1 - 4.1e-46 156.7 12.6 4.8e-46 156.5 12.6 1.0 1 0 0 1 1 1 1 Snf7 CLZ PF16526.5 EMD68262.1 - 0.0034 17.7 5.2 0.025 14.9 0.0 3.5 2 1 1 3 3 3 1 C-terminal leucine zipper domain of cyclic nucleotide-gated channels HSDR_N PF04313.14 EMD68262.1 - 0.012 15.6 1.5 0.012 15.6 1.5 1.5 1 1 1 2 2 2 0 Type I restriction enzyme R protein N terminus (HSDR_N) DUF4201 PF13870.6 EMD68262.1 - 0.023 14.4 11.9 0.12 12.2 11.0 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4201) DUF848 PF05852.11 EMD68262.1 - 0.041 14.0 5.8 0.027 14.6 3.0 2.0 1 1 1 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) FlaC_arch PF05377.11 EMD68262.1 - 0.042 14.2 6.0 3.5 8.1 0.1 3.4 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) DUF948 PF06103.11 EMD68262.1 - 0.049 13.9 1.1 0.57 10.5 0.5 2.3 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) NPV_P10 PF05531.12 EMD68262.1 - 0.054 14.0 11.9 0.77 10.3 1.3 3.3 2 1 0 3 3 3 0 Nucleopolyhedrovirus P10 protein Prefoldin_2 PF01920.20 EMD68262.1 - 0.073 13.0 0.0 0.073 13.0 0.0 3.5 2 1 1 3 3 3 0 Prefoldin subunit Nup88 PF10168.9 EMD68262.1 - 0.13 10.1 6.9 0.17 9.7 6.9 1.1 1 0 0 1 1 1 0 Nuclear pore component Allexi_40kDa PF05549.11 EMD68262.1 - 0.15 11.5 2.8 0.61 9.5 0.2 2.2 1 1 1 2 2 2 0 Allexivirus 40kDa protein DUF4407 PF14362.6 EMD68262.1 - 0.48 9.7 11.3 0.81 9.0 11.1 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Atg14 PF10186.9 EMD68262.1 - 0.52 9.3 9.4 0.92 8.5 9.5 1.3 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 FliJ PF02050.16 EMD68262.1 - 0.54 10.5 15.5 1.8 8.8 0.1 2.8 1 1 2 3 3 3 0 Flagellar FliJ protein FapA PF03961.13 EMD68262.1 - 0.85 8.2 11.1 0.6 8.6 4.3 2.0 1 1 1 2 2 2 0 Flagellar Assembly Protein A FadA PF09403.10 EMD68262.1 - 0.96 10.0 12.1 0.63 10.6 7.4 2.3 1 1 1 2 2 2 0 Adhesion protein FadA GrpE PF01025.19 EMD68262.1 - 1.5 8.4 10.1 2.6 7.7 8.0 2.1 1 1 1 2 2 2 0 GrpE BshC PF10079.9 EMD68262.1 - 2.3 6.9 9.1 3.1 6.4 9.1 1.1 1 0 0 1 1 1 0 Bacillithiol biosynthesis BshC CorA PF01544.18 EMD68262.1 - 4.3 6.6 6.8 23 4.2 6.9 2.0 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein Suc_Fer-like PF06999.12 EMD68263.1 - 1.1e-70 237.5 0.0 1.3e-70 237.2 0.0 1.1 1 0 0 1 1 1 1 Sucrase/ferredoxin-like DUF5130 PF17174.4 EMD68264.1 - 0.14 12.4 0.0 0.29 11.3 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5130) REPA_OB_2 PF16900.5 EMD68264.1 - 0.14 12.1 0.0 0.25 11.3 0.0 1.3 1 0 0 1 1 1 0 Replication protein A OB domain HET PF06985.11 EMD68265.1 - 1.6e-26 93.4 0.1 2.6e-26 92.7 0.1 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) zf-TAZ PF02135.16 EMD68265.1 - 9.3 6.8 8.7 0.24 11.9 1.0 2.4 3 0 0 3 3 3 0 TAZ zinc finger HTH_Tnp_Tc5 PF03221.16 EMD68266.1 - 6.2e-05 22.9 0.1 0.00012 22.1 0.1 1.5 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EMD68266.1 - 0.00055 19.6 0.1 0.00083 19.0 0.1 1.3 1 0 0 1 1 1 1 helix-turn-helix, Psq domain Ribosomal_S13_N PF08069.12 EMD68266.1 - 0.011 15.7 0.0 0.017 15.1 0.0 1.3 1 0 0 1 1 1 0 Ribosomal S13/S15 N-terminal domain TnsD PF15978.5 EMD68266.1 - 0.012 14.6 0.2 0.015 14.4 0.2 1.0 1 0 0 1 1 1 0 Tn7-like transposition protein D Cdc6_C PF09079.11 EMD68266.1 - 0.017 15.1 0.0 3.5 7.7 0.0 2.2 2 0 0 2 2 2 0 CDC6, C terminal winged helix domain HTH_24 PF13412.6 EMD68266.1 - 0.022 14.3 0.1 0.28 10.8 0.0 2.3 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding DUF2721 PF11026.8 EMD68266.1 - 0.16 11.8 1.0 0.22 11.4 1.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2721) CKAP2_C PF15297.6 EMD68267.1 - 0.42 9.6 5.2 0.5 9.4 5.2 1.1 1 0 0 1 1 1 0 Cytoskeleton-associated protein 2 C-terminus Rif1_N PF12231.8 EMD68269.1 - 7.4e-115 383.9 0.9 1.1e-114 383.3 0.9 1.3 1 0 0 1 1 1 1 Rap1-interacting factor 1 N terminal Ric8 PF10165.9 EMD68270.1 - 3.5e-122 408.8 0.6 3.9e-122 408.6 0.6 1.0 1 0 0 1 1 1 1 Guanine nucleotide exchange factor synembryn Tht1 PF04163.12 EMD68271.1 - 2.3e-05 23.4 18.6 9.9e-05 21.3 13.3 2.9 1 1 1 2 2 2 1 Tht1-like nuclear fusion protein TCTP PF00838.17 EMD68271.1 - 0.041 14.2 2.8 0.081 13.3 2.8 1.5 1 0 0 1 1 1 0 Translationally controlled tumour protein Cnd1 PF12717.7 EMD68271.1 - 0.054 13.5 3.1 0.15 12.1 1.9 2.1 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 Phage_Mu_Gam PF07352.12 EMD68271.1 - 0.19 11.6 4.5 0.055 13.4 0.6 2.0 2 0 0 2 2 2 0 Bacteriophage Mu Gam like protein ApoLp-III PF07464.11 EMD68271.1 - 0.36 10.9 7.7 2.1 8.4 7.1 2.5 1 1 1 2 2 2 0 Apolipophorin-III precursor (apoLp-III) Baculo_PEP_C PF04513.12 EMD68271.1 - 0.85 9.7 7.6 0.58 10.2 2.2 2.4 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF948 PF06103.11 EMD68271.1 - 1.4 9.2 9.0 0.65 10.3 0.8 3.6 4 1 0 4 4 4 0 Bacterial protein of unknown function (DUF948) UPF0240 PF06784.11 EMD68271.1 - 1.7 8.7 10.8 5.1 7.1 3.1 3.1 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0240) EspB PF05802.11 EMD68271.1 - 6.4 6.7 10.0 3.8 7.5 0.5 2.8 1 1 1 2 2 2 0 Enterobacterial EspB protein DUF155 PF02582.14 EMD68271.1 - 7.1 6.7 7.4 11 6.1 6.3 1.8 1 1 1 2 2 2 0 Uncharacterised ACR, YagE family COG1723 DUF745 PF05335.13 EMD68271.1 - 8.1 6.1 16.9 0.061 13.1 1.3 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF745) Ribosomal_L6 PF00347.23 EMD68272.1 - 4.4e-22 78.5 0.0 2.8e-10 40.7 0.0 3.0 2 2 0 2 2 2 2 Ribosomal protein L6 Rab5ip PF07019.12 EMD68273.1 - 0.0084 16.7 4.7 0.039 14.5 0.0 3.1 2 1 2 4 4 4 1 Rab5-interacting protein (Rab5ip) PgpA PF04608.13 EMD68273.1 - 0.054 13.5 0.6 0.054 13.5 0.6 2.8 3 0 0 3 3 3 0 Phosphatidylglycerophosphatase A DUF2628 PF10947.8 EMD68273.1 - 0.69 10.3 0.1 0.69 10.3 0.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2628) Peptidase_S64 PF08192.11 EMD68274.1 - 0.0032 16.1 0.7 0.0073 14.9 0.7 1.5 1 1 0 1 1 1 1 Peptidase family S64 zf-C2H2_2 PF12756.7 EMD68275.1 - 4e-33 113.8 15.8 7.8e-27 93.6 5.1 3.5 3 0 0 3 3 3 3 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.8 EMD68275.1 - 9.2e-08 32.2 7.4 4.3e-06 26.9 4.8 4.2 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EMD68275.1 - 3e-07 30.6 11.2 3.3e-06 27.3 4.7 2.9 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 EMD68275.1 - 0.002 18.8 19.4 0.77 10.8 0.3 5.0 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2 PF00096.26 EMD68275.1 - 0.021 15.2 24.2 0.036 14.5 0.3 4.6 4 0 0 4 4 4 0 Zinc finger, C2H2 type zf-DBF PF07535.12 EMD68275.1 - 0.089 12.9 7.8 1.1 9.5 0.9 3.9 3 0 0 3 3 3 0 DBF zinc finger Mso1_Sec1_bdg PF14475.6 EMD68275.1 - 0.2 11.2 3.4 0.92 9.2 0.1 3.3 3 0 0 3 3 3 0 Sec1-binding region of Mso1 HECT PF00632.25 EMD68276.1 - 1.5e-69 234.9 0.0 8.1e-69 232.4 0.0 1.9 2 0 0 2 2 2 1 HECT-domain (ubiquitin-transferase) AZUL PF16558.5 EMD68276.1 - 1.4e-21 76.5 1.5 3.5e-21 75.2 1.5 1.8 1 0 0 1 1 1 1 Amino-terminal Zinc-binding domain of ubiquitin ligase E3A Nop14 PF04147.12 EMD68277.1 - 0.096 10.9 5.7 0.13 10.5 5.7 1.1 1 0 0 1 1 1 0 Nop14-like family RNA_pol_Rpb4 PF03874.16 EMD68277.1 - 0.1 12.9 1.9 0.21 11.9 1.9 1.4 1 0 0 1 1 1 0 RNA polymerase Rpb4 CENP-B_dimeris PF09026.10 EMD68277.1 - 0.19 12.2 10.0 0.41 11.0 10.0 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain NOA36 PF06524.12 EMD68277.1 - 0.43 9.8 8.9 0.72 9.1 8.9 1.2 1 0 0 1 1 1 0 NOA36 protein DNA_pol_phi PF04931.13 EMD68277.1 - 0.49 8.4 8.3 9 4.3 11.5 1.4 2 0 0 2 2 2 0 DNA polymerase phi BSP_II PF05432.11 EMD68277.1 - 4.5 6.9 11.4 7.6 6.1 11.4 1.2 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Nuc_sug_transp PF04142.15 EMD68280.1 - 2.1e-107 358.9 14.3 4.5e-107 357.9 14.3 1.5 1 0 0 1 1 1 1 Nucleotide-sugar transporter Sec63 PF02889.16 EMD68280.1 - 3.1e-29 101.9 0.0 6.1e-29 101.0 0.0 1.5 1 0 0 1 1 1 1 Sec63 Brl domain DEAD PF00270.29 EMD68280.1 - 7.6e-23 81.2 0.0 1.8e-22 79.9 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 EMD68280.1 - 9.1e-13 48.6 0.0 1.9e-12 47.5 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EMD68280.1 - 6e-09 36.2 0.0 2.1e-08 34.5 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain EamA PF00892.20 EMD68280.1 - 0.00079 19.6 7.1 0.00079 19.6 7.1 2.4 2 0 0 2 2 2 1 EamA-like transporter family HHH_5 PF14520.6 EMD68280.1 - 0.0008 20.0 0.0 0.0038 17.8 0.0 2.1 2 0 0 2 2 2 1 Helix-hairpin-helix domain UAA PF08449.11 EMD68280.1 - 0.0056 15.9 16.7 0.051 12.8 1.9 2.3 2 0 0 2 2 2 2 UAA transporter family TPT PF03151.16 EMD68280.1 - 0.02 14.3 14.6 0.056 12.8 3.7 2.4 2 0 0 2 2 2 0 Triose-phosphate Transporter family T2SSE PF00437.20 EMD68280.1 - 0.06 12.4 0.0 0.14 11.2 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_19 PF13245.6 EMD68280.1 - 0.1 13.0 0.0 0.42 10.9 0.0 2.1 2 0 0 2 2 2 0 AAA domain HET PF06985.11 EMD68281.1 - 1.1e-31 110.2 1.0 2.6e-31 108.9 1.0 1.7 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) AAA_25 PF13481.6 EMD68281.1 - 0.036 13.6 0.1 0.082 12.5 0.1 1.6 1 0 0 1 1 1 0 AAA domain tRNA-synt_2c PF01411.19 EMD68281.1 - 0.17 10.3 0.1 0.28 9.7 0.1 1.2 1 0 0 1 1 1 0 tRNA synthetases class II (A) ABC2_membrane PF01061.24 EMD68282.1 - 6e-84 280.7 52.7 9.1e-47 159.2 21.0 3.3 4 0 0 4 4 4 2 ABC-2 type transporter ABC_tran PF00005.27 EMD68282.1 - 8.7e-36 123.4 0.0 1.9e-16 60.8 0.0 2.6 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.12 EMD68282.1 - 3e-34 116.8 3.9 2.5e-28 97.8 0.1 3.1 2 0 0 2 2 2 2 CDR ABC transporter ABC2_membrane_3 PF12698.7 EMD68282.1 - 8.1e-12 44.9 39.4 5.5e-07 29.0 19.4 2.3 2 0 0 2 2 2 2 ABC-2 family transporter protein ABC_trans_N PF14510.6 EMD68282.1 - 1.5e-10 41.6 2.4 1.6e-10 41.4 0.3 2.3 2 0 0 2 2 1 1 ABC-transporter N-terminal RsgA_GTPase PF03193.16 EMD68282.1 - 2.7e-05 24.1 0.0 0.0002 21.3 0.0 2.1 2 0 0 2 2 2 1 RsgA GTPase AAA_21 PF13304.6 EMD68282.1 - 8.1e-05 22.6 0.1 0.43 10.4 0.0 2.8 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_25 PF13481.6 EMD68282.1 - 0.00014 21.5 1.1 0.017 14.7 0.2 3.1 3 0 0 3 3 3 1 AAA domain AAA_18 PF13238.6 EMD68282.1 - 0.0003 21.3 0.0 0.039 14.5 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EMD68282.1 - 0.00043 20.7 0.6 0.011 16.1 0.0 3.0 3 0 0 3 3 3 1 AAA ATPase domain AAA_17 PF13207.6 EMD68282.1 - 0.0013 19.1 0.1 0.15 12.5 0.0 2.9 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 EMD68282.1 - 0.0023 17.6 0.5 0.17 11.6 0.2 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_22 PF13401.6 EMD68282.1 - 0.0054 17.0 0.1 0.12 12.6 0.0 2.6 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 EMD68282.1 - 0.007 16.4 0.0 0.46 10.6 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_28 PF13521.6 EMD68282.1 - 0.021 15.1 0.1 0.021 15.1 0.1 2.1 2 0 0 2 2 1 0 AAA domain DUF3600 PF12207.8 EMD68282.1 - 0.031 14.2 0.0 0.073 13.0 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3600) AAA_33 PF13671.6 EMD68282.1 - 0.044 13.9 0.0 0.31 11.2 0.0 2.4 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 EMD68282.1 - 0.051 13.2 0.3 0.16 11.6 0.1 1.8 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_23 PF13476.6 EMD68282.1 - 0.11 12.9 3.5 0.66 10.5 0.1 2.7 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 EMD68282.1 - 0.13 12.2 1.2 0.36 10.7 0.2 2.1 2 0 0 2 2 2 0 NACHT domain dNK PF01712.19 EMD68282.1 - 0.14 12.0 0.0 0.38 10.6 0.0 1.6 2 0 0 2 2 2 0 Deoxynucleoside kinase RNA_helicase PF00910.22 EMD68282.1 - 0.14 12.5 0.4 4.9 7.6 0.0 2.8 3 0 0 3 3 2 0 RNA helicase AAA_30 PF13604.6 EMD68282.1 - 0.56 9.9 4.4 1.1 8.9 0.4 2.8 3 0 0 3 3 3 0 AAA domain PhnG PF06754.12 EMD68282.1 - 0.76 9.7 4.2 3.3 7.6 0.0 2.5 2 0 0 2 2 2 0 Phosphonate metabolism protein PhnG End3 PF12761.7 EMD68282.1 - 1.1 9.4 7.8 1.9 8.6 0.0 3.3 3 0 0 3 3 3 0 Actin cytoskeleton-regulatory complex protein END3 Caveolin PF01146.17 EMD68282.1 - 1.3 9.0 5.2 3.3 7.7 5.2 1.7 1 0 0 1 1 1 0 Caveolin PEPCK_ATP PF01293.20 EMD68283.1 - 2.1e-217 722.4 0.0 2.4e-217 722.2 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase AAA_33 PF13671.6 EMD68283.1 - 0.13 12.5 0.0 0.3 11.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain FAD_binding_4 PF01565.23 EMD68284.1 - 3.2e-22 78.8 0.1 6.1e-22 77.9 0.1 1.5 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EMD68284.1 - 8.2e-05 22.6 0.1 0.00021 21.3 0.1 1.8 1 0 0 1 1 1 1 Berberine and berberine like Stn1 PF10451.9 EMD68286.1 - 1.1e-11 44.2 6.3 2e-10 40.0 6.3 2.1 1 1 0 1 1 1 1 Telomere regulation protein Stn1 tRNA_anti-codon PF01336.25 EMD68286.1 - 0.00017 21.5 0.5 0.0013 18.7 0.5 2.2 1 1 0 1 1 1 1 OB-fold nucleic acid binding domain SHS2_Rpb7-N PF03876.17 EMD68286.1 - 0.1 13.0 0.1 0.22 11.9 0.1 1.5 1 0 0 1 1 1 0 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 ECH_1 PF00378.20 EMD68286.1 - 0.41 9.9 4.4 0.55 9.5 4.4 1.1 1 0 0 1 1 1 0 Enoyl-CoA hydratase/isomerase DDRGK PF09756.9 EMD68286.1 - 8.4 5.9 19.6 14 5.2 19.6 1.3 1 0 0 1 1 1 0 DDRGK domain Granulin PF00396.18 EMD68287.1 - 0.045 14.1 6.2 0.045 14.1 6.2 2.4 1 1 1 2 2 2 0 Granulin SnoaL_2 PF12680.7 EMD68288.1 - 0.072 13.7 0.0 0.1 13.2 0.0 1.4 1 0 0 1 1 1 0 SnoaL-like domain DUF2358 PF10184.9 EMD68288.1 - 0.11 12.8 0.0 0.16 12.2 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2358) Inv-AAD PF18785.1 EMD68289.1 - 9.3e-61 203.4 0.1 1.1e-60 203.2 0.1 1.0 1 0 0 1 1 1 1 Invertebrate-AID/APOBEC-deaminase dCMP_cyt_deam_1 PF00383.23 EMD68289.1 - 5.7e-15 55.0 0.0 7.9e-15 54.6 0.0 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region APOBEC_N PF08210.11 EMD68289.1 - 0.0028 17.6 0.0 0.0035 17.3 0.0 1.1 1 0 0 1 1 1 1 APOBEC-like N-terminal domain MafB19-deam PF14437.6 EMD68289.1 - 0.024 14.4 0.0 0.036 13.8 0.0 1.4 1 1 0 1 1 1 0 MafB19-like deaminase Bd3614-deam PF14439.6 EMD68289.1 - 0.072 13.2 0.0 0.21 11.7 0.0 1.7 1 1 0 1 1 1 0 Bd3614-like deaminase DnaJ PF00226.31 EMD68290.1 - 1.9e-23 82.3 1.6 6e-23 80.7 1.6 1.9 1 0 0 1 1 1 1 DnaJ domain PEP-utilisers_N PF05524.13 EMD68290.1 - 0.0093 16.1 1.5 0.019 15.1 0.2 2.3 1 1 1 2 2 2 1 PEP-utilising enzyme, N-terminal SMN PF06003.12 EMD68291.1 - 6.2 6.0 10.1 8 5.6 10.1 1.2 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) COX7B PF05392.11 EMD68292.1 - 0.2 11.4 1.2 0.67 9.7 0.1 2.3 2 0 0 2 2 2 0 Cytochrome C oxidase chain VIIB Torus PF16131.5 EMD68293.1 - 0.04 14.6 0.3 0.093 13.4 0.3 1.6 1 0 0 1 1 1 0 Torus domain DUF3246 PF11596.8 EMD68293.1 - 0.16 11.4 8.6 0.28 10.6 8.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) SHE3 PF17078.5 EMD68294.1 - 3e-05 23.9 5.6 6.2e-05 22.8 5.6 1.5 1 0 0 1 1 1 1 SWI5-dependent HO expression protein 3 CENP-F_leu_zip PF10473.9 EMD68294.1 - 0.00053 20.0 18.6 0.023 14.7 13.1 2.7 1 1 1 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 bZIP_1 PF00170.21 EMD68294.1 - 0.00056 20.0 13.9 0.07 13.2 1.4 3.5 3 0 0 3 3 3 2 bZIP transcription factor APG17 PF04108.12 EMD68294.1 - 0.002 17.3 2.9 0.0028 16.8 2.9 1.2 1 0 0 1 1 1 1 Autophagy protein Apg17 DUF1664 PF07889.12 EMD68294.1 - 0.0035 17.4 7.1 0.097 12.7 2.6 2.5 1 1 1 2 2 2 1 Protein of unknown function (DUF1664) Prefoldin_2 PF01920.20 EMD68294.1 - 0.0048 16.8 11.5 0.83 9.6 0.1 2.7 1 1 1 2 2 2 2 Prefoldin subunit PI3K_P85_iSH2 PF16454.5 EMD68294.1 - 0.0057 16.3 5.2 0.0057 16.3 5.2 1.9 1 1 1 2 2 2 1 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain ZapB PF06005.12 EMD68294.1 - 0.0059 17.0 5.6 0.0059 17.0 5.6 3.5 1 1 1 2 2 1 1 Cell division protein ZapB DUF724 PF05266.14 EMD68294.1 - 0.01 15.7 6.1 0.01 15.7 6.1 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF724) HAP1_N PF04849.13 EMD68294.1 - 0.012 14.9 8.1 0.024 13.9 8.1 1.5 1 0 0 1 1 1 0 HAP1 N-terminal conserved region APG6_N PF17675.1 EMD68294.1 - 0.016 15.8 5.9 0.016 15.8 5.9 2.3 1 1 1 2 2 2 0 Apg6 coiled-coil region FliJ PF02050.16 EMD68294.1 - 0.016 15.4 2.6 0.016 15.4 2.6 2.2 1 1 1 2 2 2 0 Flagellar FliJ protein Laminin_I PF06008.14 EMD68294.1 - 0.021 14.6 6.6 0.03 14.0 6.6 1.2 1 0 0 1 1 1 0 Laminin Domain I DUF4200 PF13863.6 EMD68294.1 - 0.023 15.1 4.9 0.023 15.1 4.9 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) AAA_13 PF13166.6 EMD68294.1 - 0.032 12.9 4.5 0.044 12.4 4.5 1.1 1 0 0 1 1 1 0 AAA domain DUF4407 PF14362.6 EMD68294.1 - 0.035 13.5 3.4 0.058 12.7 3.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF2353 PF09789.9 EMD68294.1 - 0.041 13.3 8.7 0.045 13.1 4.9 2.0 1 1 1 2 2 2 0 Uncharacterized coiled-coil protein (DUF2353) EzrA PF06160.12 EMD68294.1 - 0.043 12.0 7.6 0.018 13.2 4.3 1.6 1 1 0 1 1 1 0 Septation ring formation regulator, EzrA HALZ PF02183.18 EMD68294.1 - 0.048 13.9 5.7 2.2 8.6 0.2 3.5 3 0 0 3 3 3 0 Homeobox associated leucine zipper DUF812 PF05667.11 EMD68294.1 - 0.051 12.4 8.5 0.065 12.1 8.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF812) DUF4795 PF16043.5 EMD68294.1 - 0.06 12.9 5.9 0.096 12.3 5.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4795) GAS PF13851.6 EMD68294.1 - 0.073 12.4 13.7 0.042 13.2 7.0 2.2 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding DUF3450 PF11932.8 EMD68294.1 - 0.079 12.3 8.4 0.024 13.9 4.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) JIP_LZII PF16471.5 EMD68294.1 - 0.092 12.9 17.1 0.27 11.5 0.4 3.3 2 1 1 3 3 3 0 JNK-interacting protein leucine zipper II FUSC PF04632.12 EMD68294.1 - 0.14 10.6 5.0 0.19 10.2 5.0 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF4201 PF13870.6 EMD68294.1 - 0.15 11.8 11.5 0.31 10.8 9.5 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) FapA PF03961.13 EMD68294.1 - 0.16 10.5 7.0 0.15 10.6 5.6 1.4 1 1 0 1 1 1 0 Flagellar Assembly Protein A HIP1_clath_bdg PF16515.5 EMD68294.1 - 0.18 12.4 15.2 0.096 13.3 7.1 3.1 1 1 2 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Seryl_tRNA_N PF02403.22 EMD68294.1 - 0.22 11.8 12.5 0.95 9.7 5.2 2.4 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Spc7 PF08317.11 EMD68294.1 - 0.23 10.3 14.2 0.62 8.9 14.3 1.6 1 1 0 1 1 1 0 Spc7 kinetochore protein Macoilin PF09726.9 EMD68294.1 - 0.23 10.0 9.7 0.31 9.5 9.7 1.1 1 0 0 1 1 1 0 Macoilin family LPP PF04728.13 EMD68294.1 - 0.32 11.4 3.3 39 4.8 0.1 3.4 3 0 0 3 3 3 0 Lipoprotein leucine-zipper TPR_MLP1_2 PF07926.12 EMD68294.1 - 0.32 11.1 16.7 2.5 8.2 10.9 2.6 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Atg14 PF10186.9 EMD68294.1 - 0.32 10.0 8.8 0.56 9.2 8.8 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 TolA_bind_tri PF16331.5 EMD68294.1 - 0.35 11.0 10.6 0.92 9.6 0.3 3.1 2 1 1 3 3 3 0 TolA binding protein trimerisation Fez1 PF06818.15 EMD68294.1 - 0.39 11.2 14.6 1.1 9.6 14.6 1.8 1 1 0 1 1 1 0 Fez1 Spectrin PF00435.21 EMD68294.1 - 0.39 11.2 5.0 0.82 10.2 3.5 2.1 1 1 1 2 2 2 0 Spectrin repeat Cnn_1N PF07989.11 EMD68294.1 - 0.41 10.8 11.3 0.067 13.4 3.6 2.6 1 1 1 2 2 2 0 Centrosomin N-terminal motif 1 BLOC1_2 PF10046.9 EMD68294.1 - 0.48 10.8 6.8 8.6 6.7 0.1 3.0 1 1 2 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 BRE1 PF08647.11 EMD68294.1 - 0.53 10.4 12.5 2.8 8.1 7.9 2.3 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase Uso1_p115_C PF04871.13 EMD68294.1 - 0.54 10.6 15.1 0.45 10.9 5.9 2.3 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region KASH_CCD PF14662.6 EMD68294.1 - 0.56 10.0 15.2 2.1 8.1 15.3 1.9 1 1 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH PRKG1_interact PF15898.5 EMD68294.1 - 0.6 11.0 14.9 1.8 9.5 7.7 3.0 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain DUF4140 PF13600.6 EMD68294.1 - 0.65 10.5 12.4 20 5.7 1.4 4.1 2 1 2 4 4 4 0 N-terminal domain of unknown function (DUF4140) Prominin PF05478.11 EMD68294.1 - 0.87 7.5 1.9 1.2 7.0 1.9 1.2 1 0 0 1 1 1 0 Prominin DivIC PF04977.15 EMD68294.1 - 1.2 9.0 10.1 6.7 6.6 0.2 3.4 1 1 2 3 3 3 0 Septum formation initiator DUF4618 PF15397.6 EMD68294.1 - 1.3 8.4 9.0 2.1 7.7 2.6 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4618) Leu_zip PF15294.6 EMD68294.1 - 1.4 8.4 12.3 6 6.3 12.2 1.9 1 1 0 1 1 1 0 Leucine zipper ADIP PF11559.8 EMD68294.1 - 1.7 8.7 12.6 0.38 10.8 4.5 2.3 1 1 0 2 2 2 0 Afadin- and alpha -actinin-Binding CdvA PF18822.1 EMD68294.1 - 2 8.3 12.5 0.33 10.8 7.1 2.1 1 1 1 2 2 2 0 CdvA-like coiled-coil domain Nup88 PF10168.9 EMD68294.1 - 2.3 5.9 11.2 3 5.5 11.2 1.1 1 0 0 1 1 1 0 Nuclear pore component Lebercilin PF15619.6 EMD68294.1 - 2.4 7.8 17.2 17 5.0 17.2 2.0 1 1 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease SlyX PF04102.12 EMD68294.1 - 2.5 8.8 5.3 6.9 7.4 1.7 3.1 1 1 2 3 3 3 0 SlyX DUF1640 PF07798.11 EMD68294.1 - 2.7 8.0 9.7 5.8 6.9 9.4 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1640) YabA PF06156.13 EMD68294.1 - 2.8 8.6 11.6 27 5.5 6.6 2.8 1 1 1 2 2 2 0 Initiation control protein YabA DUF641 PF04859.12 EMD68294.1 - 3.1 8.1 10.9 0.62 10.4 4.3 2.3 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) DHR10 PF18595.1 EMD68294.1 - 3.3 7.8 18.3 2.7 8.1 8.1 2.8 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain TMF_TATA_bd PF12325.8 EMD68294.1 - 3.3 7.9 18.3 3.2 8.0 9.1 2.8 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding THOC7 PF05615.13 EMD68294.1 - 3.9 7.8 13.8 13 6.1 11.5 2.4 1 1 1 2 2 2 0 Tho complex subunit 7 Csm1_N PF18504.1 EMD68294.1 - 4.1 7.8 12.3 16 6.0 0.5 3.3 1 1 1 3 3 3 0 Csm1 N-terminal domain ERM PF00769.19 EMD68294.1 - 4.1 7.2 21.1 7.6 6.3 21.1 1.4 1 0 0 1 1 1 0 Ezrin/radixin/moesin family OmpH PF03938.14 EMD68294.1 - 4.3 7.7 11.0 19 5.6 11.0 2.0 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) FlaC_arch PF05377.11 EMD68294.1 - 4.8 7.6 10.8 2.7 8.4 2.1 3.4 2 1 0 3 3 3 0 Flagella accessory protein C (FlaC) DUF5320 PF17253.2 EMD68294.1 - 6 8.0 7.2 7 7.8 1.3 2.9 2 1 1 3 3 2 0 Family of unknown function (DUF5320) ABC_tran_CTD PF16326.5 EMD68294.1 - 6.3 7.1 14.0 4.7 7.5 3.7 3.5 1 1 2 3 3 3 0 ABC transporter C-terminal domain GrpE PF01025.19 EMD68294.1 - 6.9 6.3 14.1 2.8 7.6 4.6 2.5 1 1 1 2 2 2 0 GrpE HAUS-augmin3 PF14932.6 EMD68294.1 - 7.2 6.1 10.9 1.3 8.5 5.9 1.9 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 3 Jnk-SapK_ap_N PF09744.9 EMD68294.1 - 7.9 6.7 16.9 16 5.7 11.0 2.2 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 Acid_PPase PF12689.7 EMD68295.1 - 1.6e-21 76.9 0.0 2e-21 76.6 0.0 1.1 1 0 0 1 1 1 1 Acid Phosphatase G_glu_transpept PF01019.21 EMD68296.1 - 1.2e-141 473.1 0.0 1.6e-141 472.6 0.0 1.2 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase PCRF PF03462.18 EMD68297.1 - 1.4e-52 178.4 0.1 4.6e-52 176.7 0.0 1.9 2 0 0 2 2 2 1 PCRF domain RF-1 PF00472.20 EMD68297.1 - 6.4e-35 119.6 2.9 1.5e-34 118.4 2.9 1.6 1 0 0 1 1 1 1 RF-1 domain UQ_con PF00179.26 EMD68299.1 - 1.7e-35 121.7 0.1 2.1e-35 121.4 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Pantoate_transf PF02548.15 EMD68300.1 - 1.3e-106 355.8 0.8 1.5e-106 355.5 0.8 1.1 1 0 0 1 1 1 1 Ketopantoate hydroxymethyltransferase PEP_mutase PF13714.6 EMD68300.1 - 8.1e-08 32.0 0.2 1.4e-07 31.2 0.2 1.5 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase DUF4861 PF16153.5 EMD68300.1 - 0.036 13.1 0.0 0.052 12.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4861) YceG PF02618.16 EMD68300.1 - 0.14 11.7 0.0 0.23 11.0 0.0 1.3 1 1 0 1 1 1 0 YceG-like family DEAD PF00270.29 EMD68301.1 - 3.2e-41 141.0 0.1 4.7e-41 140.5 0.1 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EMD68301.1 - 5.1e-21 75.1 0.1 2.5e-20 72.9 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EMD68301.1 - 3.1e-06 27.3 0.1 4.9e-06 26.7 0.1 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EMD68301.1 - 0.046 12.9 0.0 0.08 12.1 0.0 1.3 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase Com_YlbF PF06133.11 EMD68301.1 - 0.15 12.7 1.1 0.31 11.7 0.4 1.8 2 0 0 2 2 2 0 Control of competence regulator ComK, YlbF/YmcA Dfp1_Him1_M PF08630.10 EMD68304.1 - 4.9e-36 123.7 0.1 4.9e-36 123.7 0.1 2.4 2 0 0 2 2 2 1 Dfp1/Him1, central region zf-DBF PF07535.12 EMD68304.1 - 3.7e-21 74.9 0.2 6.3e-21 74.2 0.2 1.4 1 0 0 1 1 1 1 DBF zinc finger BRCT PF00533.26 EMD68304.1 - 0.012 16.0 0.0 0.029 14.8 0.0 1.7 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain Antimicrobial_7 PF08102.11 EMD68304.1 - 0.071 13.3 1.2 1.6 9.0 0.1 2.5 2 0 0 2 2 2 0 Scorpion antimicrobial peptide zf-C2H2_jaz PF12171.8 EMD68304.1 - 5 7.5 5.0 14 6.1 2.6 2.7 2 1 0 2 2 2 0 Zinc-finger double-stranded RNA-binding APG12 PF04110.13 EMD68305.1 - 9.9e-26 90.0 0.0 1.2e-25 89.7 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Atg8 PF02991.16 EMD68305.1 - 0.13 12.4 0.0 0.15 12.3 0.0 1.1 1 0 0 1 1 1 0 Autophagy protein Atg8 ubiquitin like UQ_con PF00179.26 EMD68307.1 - 1.3e-51 173.9 0.0 1.5e-51 173.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EMD68307.1 - 0.0018 18.0 0.0 0.002 17.8 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 EMD68307.1 - 0.11 12.8 0.0 0.22 11.8 0.0 1.5 1 1 0 1 1 1 0 RWD domain Sulfatase PF00884.23 EMD68308.1 - 1.6e-56 192.0 0.0 2e-56 191.7 0.0 1.1 1 0 0 1 1 1 1 Sulfatase Choline_sulf_C PF12411.8 EMD68308.1 - 3.6e-22 77.9 0.9 1.4e-21 76.1 0.1 2.3 1 1 1 2 2 2 1 Choline sulfatase enzyme C terminal Phosphodiest PF01663.22 EMD68308.1 - 1.8e-05 24.5 0.1 0.00053 19.7 0.1 2.2 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase DUF4976 PF16347.5 EMD68308.1 - 0.01 16.1 0.0 0.022 15.0 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4976) Sulfatase_C PF14707.6 EMD68308.1 - 0.01 16.6 0.0 0.031 15.0 0.0 1.8 1 0 0 1 1 1 0 C-terminal region of aryl-sulfatase Pkinase PF00069.25 EMD68310.1 - 2e-45 155.2 0.0 8.7e-45 153.1 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD68310.1 - 2.2e-30 105.8 0.0 3.2e-30 105.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMD68310.1 - 0.00087 18.7 0.0 0.0016 17.9 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EMD68310.1 - 0.0011 17.9 0.0 0.0015 17.4 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EMD68310.1 - 0.02 14.2 0.0 0.037 13.4 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Piwi PF02171.17 EMD68310.1 - 0.025 13.9 0.0 0.043 13.1 0.0 1.3 1 0 0 1 1 1 0 Piwi domain Aldose_epim PF01263.20 EMD68311.1 - 3.5e-42 144.8 0.0 3.9e-42 144.6 0.0 1.0 1 0 0 1 1 1 1 Aldose 1-epimerase Pox_A6 PF04924.12 EMD68311.1 - 0.033 13.2 0.1 0.043 12.8 0.1 1.1 1 0 0 1 1 1 0 Poxvirus A6 protein MFS_1 PF07690.16 EMD68313.1 - 2.8e-28 98.9 16.0 4.6e-28 98.2 16.0 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EMD68313.1 - 3.2e-09 36.2 16.0 0.0004 19.4 0.2 3.7 2 2 1 3 3 3 3 Sugar (and other) transporter PUCC PF03209.15 EMD68313.1 - 0.00097 18.2 2.4 0.0031 16.6 0.0 2.5 3 0 0 3 3 3 1 PUCC protein BT1 PF03092.16 EMD68313.1 - 0.015 13.5 5.4 0.14 10.3 0.0 2.4 2 1 1 3 3 3 0 BT1 family OATP PF03137.20 EMD68313.1 - 0.3 9.3 13.6 0.017 13.5 0.8 3.1 2 1 0 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family AMP-binding PF00501.28 EMD68315.1 - 3.6e-102 342.1 0.0 4.3e-102 341.9 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EMD68315.1 - 1.8e-13 51.2 0.4 4.7e-13 49.9 0.4 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Acetyltransf_8 PF13523.6 EMD68316.1 - 9.5e-40 135.6 1.9 9.5e-40 135.6 1.9 1.5 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain K_oxygenase PF13434.6 EMD68317.1 - 1.9e-50 171.9 0.0 1.1e-49 169.4 0.0 1.9 1 1 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) Lycopene_cycl PF05834.12 EMD68317.1 - 0.074 12.1 0.0 0.13 11.3 0.0 1.4 1 0 0 1 1 1 0 Lycopene cyclase protein NAD_binding_9 PF13454.6 EMD68317.1 - 0.12 12.4 0.0 0.26 11.3 0.0 1.5 1 0 0 1 1 1 0 FAD-NAD(P)-binding ABC_membrane PF00664.23 EMD68318.1 - 2.6e-81 273.3 20.6 8e-43 147.0 1.8 2.3 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EMD68318.1 - 5.1e-67 224.6 0.1 1.7e-32 112.8 0.1 2.5 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EMD68318.1 - 3.1e-13 49.7 3.0 0.00011 21.7 0.0 4.4 3 1 1 4 4 4 3 RecF/RecN/SMC N terminal domain ABC_ATPase PF09818.9 EMD68318.1 - 2.7e-08 33.1 1.0 0.00053 18.9 0.0 3.2 4 0 0 4 4 4 2 Predicted ATPase of the ABC class AAA_16 PF13191.6 EMD68318.1 - 2.6e-07 31.2 3.1 0.0062 16.9 0.0 3.2 2 1 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 EMD68318.1 - 3.6e-07 30.5 0.7 0.073 13.3 0.0 4.3 4 1 0 4 4 3 2 AAA domain AAA_29 PF13555.6 EMD68318.1 - 2.2e-06 27.3 2.4 0.022 14.5 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EMD68318.1 - 4e-06 26.8 0.0 0.13 12.1 0.0 2.7 2 0 0 2 2 2 2 RsgA GTPase AAA_30 PF13604.6 EMD68318.1 - 6.9e-06 25.9 3.1 0.32 10.7 0.0 3.9 4 0 0 4 4 4 2 AAA domain AAA_25 PF13481.6 EMD68318.1 - 7.5e-05 22.4 0.4 0.85 9.2 0.0 3.7 4 0 0 4 4 4 2 AAA domain AAA_15 PF13175.6 EMD68318.1 - 0.00011 22.1 0.1 0.24 11.1 0.1 2.2 2 0 0 2 2 2 2 AAA ATPase domain AAA_18 PF13238.6 EMD68318.1 - 0.00017 22.1 0.0 0.93 10.0 0.0 2.9 3 0 0 3 3 2 2 AAA domain AAA_21 PF13304.6 EMD68318.1 - 0.00034 20.5 3.8 0.47 10.2 0.0 3.4 3 1 0 4 4 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 EMD68318.1 - 0.00045 20.8 0.2 0.48 10.9 0.2 2.4 2 0 0 2 2 2 1 AAA domain APS_kinase PF01583.20 EMD68318.1 - 0.00052 19.9 0.1 0.041 13.8 0.0 2.4 2 0 0 2 2 2 1 Adenylylsulphate kinase AAA_33 PF13671.6 EMD68318.1 - 0.0008 19.6 0.2 1.6 8.9 0.0 2.9 3 0 0 3 3 2 2 AAA domain DNA_pol3_beta PF00712.19 EMD68318.1 - 0.0034 17.5 0.0 0.02 15.0 0.0 2.1 2 0 0 2 2 2 1 DNA polymerase III beta subunit, N-terminal domain AAA_24 PF13479.6 EMD68318.1 - 0.0044 16.8 0.1 4.2 7.0 0.0 2.6 2 1 0 2 2 2 2 AAA domain AAA_17 PF13207.6 EMD68318.1 - 0.0046 17.4 0.0 5.8 7.3 0.0 2.9 2 0 0 2 2 2 1 AAA domain Rad17 PF03215.15 EMD68318.1 - 0.0054 16.7 0.0 0.39 10.6 0.0 2.4 2 0 0 2 2 2 1 Rad17 P-loop domain DUF87 PF01935.17 EMD68318.1 - 0.0079 16.3 0.3 0.95 9.5 0.0 2.7 2 0 0 2 2 2 1 Helicase HerA, central domain SRP54 PF00448.22 EMD68318.1 - 0.0093 15.6 0.0 1.5 8.4 0.0 2.5 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_5 PF07728.14 EMD68318.1 - 0.011 15.7 0.1 12 5.9 0.0 3.3 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) Zeta_toxin PF06414.12 EMD68318.1 - 0.017 14.4 0.1 3.8 6.7 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin NB-ARC PF00931.22 EMD68318.1 - 0.02 14.1 0.0 1 8.5 0.0 2.6 2 0 0 2 2 2 0 NB-ARC domain MMR_HSR1 PF01926.23 EMD68318.1 - 0.029 14.5 0.1 12 6.0 0.0 2.7 2 0 0 2 2 2 0 50S ribosome-binding GTPase SbcCD_C PF13558.6 EMD68318.1 - 0.071 13.4 4.1 9.7 6.5 0.1 3.5 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit DUF3671 PF12420.8 EMD68318.1 - 0.14 12.3 1.2 0.51 10.4 1.2 1.9 1 0 0 1 1 1 0 Protein of unknown function PRK PF00485.18 EMD68318.1 - 0.16 11.7 0.5 12 5.5 0.0 2.7 3 0 0 3 3 3 0 Phosphoribulokinase / Uridine kinase family Acetyltransf_1 PF00583.25 EMD68319.1 - 3.5e-10 40.1 0.0 6.7e-10 39.2 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EMD68319.1 - 5.8e-09 36.0 0.0 3.3e-08 33.5 0.0 1.9 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EMD68319.1 - 1.6e-08 34.8 0.1 3.7e-08 33.7 0.1 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EMD68319.1 - 0.0019 18.3 0.0 0.0038 17.3 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Condensation PF00668.20 EMD68320.1 - 2.7e-66 224.2 0.0 4.7e-36 124.4 0.0 3.7 3 1 0 3 3 3 2 Condensation domain AMP-binding PF00501.28 EMD68320.1 - 5.7e-66 222.9 0.0 8.2e-66 222.3 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme PP-binding PF00550.25 EMD68320.1 - 6.8e-41 138.5 7.3 1e-12 48.2 0.5 3.9 3 0 0 3 3 3 3 Phosphopantetheine attachment site Tyrosinase PF00264.20 EMD68321.1 - 1.4e-25 90.9 0.1 2.4e-25 90.2 0.1 1.3 1 0 0 1 1 1 1 Common central domain of tyrosinase ECH_1 PF00378.20 EMD68323.1 - 1.5e-40 139.1 0.0 1.6e-39 135.7 0.0 1.9 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EMD68323.1 - 2.3e-30 106.3 0.0 6.5e-28 98.2 0.0 2.0 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase WD40 PF00400.32 EMD68324.1 - 1.4e-44 149.2 25.9 1.4e-08 35.2 0.2 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD68324.1 - 5e-09 36.4 0.3 0.075 13.3 0.0 4.4 3 1 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EMD68324.1 - 0.00071 18.4 6.5 0.18 10.4 0.1 4.1 2 1 3 5 5 5 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 EMD68324.1 - 0.0028 16.7 0.0 10 5.0 0.0 3.9 2 2 0 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 EMD68324.1 - 0.0059 16.5 0.0 2.1 8.2 0.0 2.9 1 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 EMD68324.1 - 0.016 14.5 0.0 1.1 8.5 0.0 2.5 2 1 2 4 4 4 0 WD40-like domain PD40 PF07676.12 EMD68324.1 - 0.026 14.5 0.9 22 5.1 0.0 4.4 6 0 0 6 6 6 0 WD40-like Beta Propeller Repeat NmrA PF05368.13 EMD68325.1 - 3.7e-14 52.8 0.0 5.1e-14 52.4 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EMD68325.1 - 4.9e-07 29.8 0.0 3.9e-06 26.9 0.0 2.4 1 1 1 2 2 2 1 NAD(P)H-binding Shikimate_DH PF01488.20 EMD68325.1 - 9.7e-05 22.5 0.0 0.00038 20.5 0.0 1.9 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase Sacchrp_dh_NADP PF03435.18 EMD68325.1 - 0.00084 19.6 0.0 0.01 16.1 0.0 2.2 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain zf-U1 PF06220.12 EMD68326.1 - 9.8e-22 76.5 3.5 1.3e-21 76.1 3.5 1.2 1 0 0 1 1 1 1 U1 zinc finger Actin_micro PF17003.5 EMD68326.1 - 0.14 11.3 0.1 0.17 11.0 0.1 1.0 1 0 0 1 1 1 0 Putative actin-like family NDUFA12 PF05071.16 EMD68328.1 - 4.7e-10 40.2 5.2 4.7e-10 40.2 5.2 2.2 2 1 0 2 2 2 1 NADH ubiquinone oxidoreductase subunit NDUFA12 CH PF00307.31 EMD68329.1 - 2e-14 53.7 0.0 3.4e-14 52.9 0.0 1.4 1 0 0 1 1 1 1 Calponin homology (CH) domain Pox_A_type_inc PF04508.12 EMD68329.1 - 0.00071 19.3 3.8 0.00071 19.3 3.8 3.4 3 0 0 3 3 3 1 Viral A-type inclusion protein repeat CCT PF06203.14 EMD68329.1 - 0.026 14.6 2.5 0.026 14.6 2.5 3.2 2 0 0 2 2 2 0 CCT motif CAMSAP_CH PF11971.8 EMD68329.1 - 0.085 12.7 0.0 0.16 11.8 0.0 1.3 1 0 0 1 1 1 0 CAMSAP CH domain DUF4404 PF14357.6 EMD68331.1 - 6 7.6 6.4 0.86 10.3 0.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) HET PF06985.11 EMD68332.1 - 2.8e-37 128.3 1.4 4.6e-37 127.6 1.4 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Ank_4 PF13637.6 EMD68332.1 - 1.5e-26 92.4 0.0 3.2e-10 40.3 0.0 3.2 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 EMD68332.1 - 3.2e-23 82.1 0.0 1.8e-10 41.2 0.0 2.7 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 EMD68332.1 - 7.4e-21 73.6 0.0 5.4e-05 23.5 0.0 4.9 4 0 0 4 4 4 4 Ankyrin repeat Ank_3 PF13606.6 EMD68332.1 - 2.7e-16 58.0 0.0 0.0032 17.8 0.0 4.9 4 0 0 4 4 4 4 Ankyrin repeat Ank_5 PF13857.6 EMD68332.1 - 5.8e-12 45.6 0.0 1.6e-05 25.0 0.0 3.1 1 1 2 3 3 3 3 Ankyrin repeats (many copies) TPR_12 PF13424.6 EMD68332.1 - 0.00096 19.4 0.0 0.003 17.8 0.0 1.8 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_10 PF13374.6 EMD68332.1 - 0.0013 18.5 0.1 0.0037 17.1 0.1 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat VWA_3_C PF18571.1 EMD68332.1 - 0.57 10.1 3.3 12 5.9 0.2 3.3 3 0 0 3 3 3 0 von Willebrand factor type A C-terminal domain DUF2981 PF11200.8 EMD68333.1 - 2.5 7.8 6.7 3.9 7.1 6.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) Totivirus_coat PF05518.11 EMD68333.1 - 2.5 6.0 9.7 3.4 5.6 9.7 1.1 1 0 0 1 1 1 0 Totivirus coat protein YL1 PF05764.13 EMD68333.1 - 7.4 6.6 31.5 0.17 12.0 9.7 2.3 2 0 0 2 2 2 0 YL1 nuclear protein Mito_carr PF00153.27 EMD68335.1 - 8.7e-21 73.7 4.0 1e-07 31.7 0.0 3.4 3 0 0 3 3 3 3 Mitochondrial carrier protein Colicin_V PF02674.16 EMD68335.1 - 0.00032 20.7 0.0 0.0055 16.7 0.0 2.3 2 1 0 2 2 2 1 Colicin V production protein NPP1 PF05630.11 EMD68336.1 - 2e-48 165.1 2.3 2.8e-48 164.7 2.3 1.1 1 0 0 1 1 1 1 Necrosis inducing protein (NPP1) EspB PF05802.11 EMD68337.1 - 0.064 13.2 0.1 0.28 11.1 0.0 1.8 2 0 0 2 2 2 0 Enterobacterial EspB protein adh_short PF00106.25 EMD68338.1 - 1.1e-06 28.2 0.0 1.9e-06 27.5 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD68338.1 - 0.0046 16.6 0.0 0.0066 16.0 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF4538 PF15061.6 EMD68338.1 - 0.1 12.3 0.0 0.21 11.3 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4538) DHDPS PF00701.22 EMD68339.1 - 2.2e-41 141.4 0.0 2.8e-41 141.1 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family Aldo_ket_red PF00248.21 EMD68340.1 - 8.2e-65 218.9 0.0 9.3e-65 218.7 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family DUF3328 PF11807.8 EMD68341.1 - 0.062 13.1 0.9 0.09 12.5 0.1 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3328) MARVEL PF01284.23 EMD68341.1 - 0.19 11.8 3.4 0.31 11.1 3.4 1.5 1 1 0 1 1 1 0 Membrane-associating domain Rtt106 PF08512.12 EMD68342.1 - 9.7e-27 93.2 0.0 2.2e-26 92.1 0.0 1.6 2 0 0 2 2 2 1 Histone chaperone Rttp106-like MIP PF00230.20 EMD68343.1 - 1.8e-49 168.5 12.0 2.2e-49 168.2 12.0 1.1 1 0 0 1 1 1 1 Major intrinsic protein SCF PF02404.15 EMD68343.1 - 0.18 11.1 0.3 0.3 10.4 0.3 1.3 1 0 0 1 1 1 0 Stem cell factor bZIP_2 PF07716.15 EMD68344.1 - 0.032 14.3 4.0 0.045 13.9 4.0 1.2 1 0 0 1 1 1 0 Basic region leucine zipper MFS_1 PF07690.16 EMD68345.1 - 2.6e-47 161.5 78.1 3e-41 141.5 53.9 2.6 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EMD68345.1 - 4.2e-07 29.2 38.3 2.4e-05 23.4 18.4 2.7 2 1 0 2 2 2 2 Sugar (and other) transporter Glyco_tran_28_C PF04101.16 EMD68346.1 - 1.2e-08 35.1 0.1 1.7e-08 34.6 0.1 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain UDPGT PF00201.18 EMD68346.1 - 3.1e-07 29.6 0.1 7.1e-07 28.4 0.0 1.5 2 0 0 2 2 2 1 UDP-glucoronosyl and UDP-glucosyl transferase Herpes_TK PF00693.18 EMD68347.1 - 0.061 12.5 0.1 0.11 11.8 0.1 1.3 1 0 0 1 1 1 0 Thymidine kinase from herpesvirus HATPase_c_3 PF13589.6 EMD68349.1 - 2.1e-17 63.3 0.0 5.7e-17 61.8 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase MutL_C PF08676.11 EMD68349.1 - 1e-09 38.3 0.2 1.2e-08 34.8 0.1 2.3 2 0 0 2 2 2 1 MutL C terminal dimerisation domain DUF1035 PF06281.12 EMD68349.1 - 0.0095 15.9 0.1 0.029 14.4 0.1 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF1035) HATPase_c PF02518.26 EMD68349.1 - 0.0096 16.4 0.1 0.036 14.6 0.0 2.0 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF1761 PF08570.10 EMD68350.1 - 2.4e-28 98.9 3.0 2.8e-28 98.7 3.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1761) Dabb PF07876.12 EMD68351.1 - 2.7e-21 76.0 0.2 3.2e-21 75.8 0.2 1.1 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain Ribosomal_L17 PF01196.19 EMD68352.1 - 1.3e-33 115.8 0.1 2.7e-33 114.7 0.1 1.6 1 0 0 1 1 1 1 Ribosomal protein L17 Ribonuc_red_lgC PF02867.15 EMD68353.1 - 1.5e-189 630.9 0.0 1.9e-189 630.6 0.0 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.21 EMD68353.1 - 8.4e-25 86.6 0.0 2e-24 85.4 0.0 1.7 1 0 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.16 EMD68353.1 - 2.3e-16 60.1 0.0 7.1e-16 58.6 0.0 1.9 1 0 0 1 1 1 1 ATP cone domain Prok-E2_B PF14461.6 EMD68353.1 - 0.026 14.2 0.0 0.068 12.9 0.0 1.7 1 0 0 1 1 1 0 Prokaryotic E2 family B YCII PF03795.14 EMD68354.1 - 8.2e-06 26.1 0.0 1.3e-05 25.5 0.0 1.3 1 1 0 1 1 1 1 YCII-related domain DUF1235 PF06822.12 EMD68355.1 - 0.027 13.8 0.2 0.029 13.7 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1235) Peptidase_S10 PF00450.22 EMD68356.1 - 6.9e-118 394.7 0.0 9.1e-118 394.3 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase GRA6 PF05084.13 EMD68356.1 - 0.00035 20.6 0.2 0.0019 18.2 0.0 2.1 1 1 0 2 2 2 1 Granule antigen protein (GRA6) Hydrolase_4 PF12146.8 EMD68356.1 - 0.2 10.9 0.0 0.77 9.0 0.0 1.8 2 0 0 2 2 2 0 Serine aminopeptidase, S33 RNA_Me_trans PF04252.13 EMD68357.1 - 2.7e-83 278.5 0.0 3e-83 278.3 0.0 1.0 1 0 0 1 1 1 1 Predicted SAM-dependent RNA methyltransferase Endosulfine PF04667.17 EMD68358.1 - 3.6e-30 103.9 0.2 5.4e-30 103.3 0.2 1.3 1 0 0 1 1 1 1 cAMP-regulated phosphoprotein/endosulfine conserved region Glyco_hydro_63 PF03200.16 EMD68359.1 - 8.4e-136 453.6 0.0 2.4e-134 448.8 0.0 2.0 1 1 0 1 1 1 1 Glycosyl hydrolase family 63 C-terminal domain Glyco_hydro_63N PF16923.5 EMD68359.1 - 1.1e-54 185.9 0.0 2.4e-54 184.8 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 63 N-terminal domain Trehalase PF01204.18 EMD68359.1 - 0.0059 15.5 0.0 0.012 14.5 0.0 1.4 1 0 0 1 1 1 1 Trehalase PRK PF00485.18 EMD68360.1 - 5.2e-07 29.6 0.0 8e-07 29.0 0.0 1.2 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family NB-ARC PF00931.22 EMD68360.1 - 1.8e-05 24.0 0.0 2.6e-05 23.5 0.0 1.1 1 0 0 1 1 1 1 NB-ARC domain AAA_16 PF13191.6 EMD68360.1 - 8e-05 23.1 0.0 0.00012 22.5 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.6 EMD68360.1 - 0.00041 20.9 0.0 0.0055 17.3 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EMD68360.1 - 0.00069 19.9 0.0 0.0012 19.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 EMD68360.1 - 0.0032 17.9 0.5 0.033 14.6 0.1 2.2 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 EMD68360.1 - 0.0042 16.4 1.4 0.0091 15.3 0.0 1.9 2 0 0 2 2 2 1 Zeta toxin T2SSE PF00437.20 EMD68360.1 - 0.0043 16.1 0.0 0.01 14.9 0.0 1.5 2 0 0 2 2 2 1 Type II/IV secretion system protein NACHT PF05729.12 EMD68360.1 - 0.0093 15.9 0.1 0.016 15.1 0.1 1.3 1 0 0 1 1 1 1 NACHT domain APS_kinase PF01583.20 EMD68360.1 - 0.013 15.4 0.0 0.025 14.5 0.0 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_30 PF13604.6 EMD68360.1 - 0.013 15.2 0.0 0.023 14.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain Thymidylate_kin PF02223.17 EMD68360.1 - 0.015 15.0 0.2 0.19 11.4 0.0 2.2 2 0 0 2 2 2 0 Thymidylate kinase NTPase_1 PF03266.15 EMD68360.1 - 0.021 14.8 0.1 0.034 14.1 0.1 1.3 1 0 0 1 1 1 0 NTPase AAA PF00004.29 EMD68360.1 - 0.023 15.1 0.0 0.039 14.4 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EMD68360.1 - 0.033 13.9 0.1 0.053 13.3 0.1 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 EMD68360.1 - 0.045 13.9 0.8 0.18 12.0 0.1 2.0 2 0 0 2 2 2 0 AAA domain dNK PF01712.19 EMD68360.1 - 0.062 13.2 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 Deoxynucleoside kinase KTI12 PF08433.10 EMD68360.1 - 0.066 12.7 0.1 0.1 12.0 0.1 1.2 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_24 PF13479.6 EMD68360.1 - 0.075 12.7 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.9 EMD68360.1 - 0.079 12.2 0.0 0.11 11.7 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Mg_chelatase PF01078.21 EMD68360.1 - 0.094 12.1 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI TsaE PF02367.17 EMD68360.1 - 0.098 12.7 0.0 0.15 12.1 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE MeaB PF03308.16 EMD68360.1 - 0.11 11.5 0.0 0.19 10.7 0.0 1.4 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB cobW PF02492.19 EMD68360.1 - 0.11 12.1 0.1 0.17 11.4 0.1 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain ABC_tran PF00005.27 EMD68360.1 - 0.13 12.7 0.0 0.23 12.0 0.0 1.4 1 0 0 1 1 1 0 ABC transporter RNA_helicase PF00910.22 EMD68360.1 - 0.19 12.1 0.0 0.34 11.3 0.0 1.4 1 0 0 1 1 1 0 RNA helicase Cytidylate_kin2 PF13189.6 EMD68360.1 - 0.2 11.8 1.2 0.8 9.8 0.0 2.0 2 0 0 2 2 2 0 Cytidylate kinase-like family Melibiase_2 PF16499.5 EMD68361.1 - 1.6e-38 132.5 0.2 3e-38 131.6 0.2 1.5 1 0 0 1 1 1 1 Alpha galactosidase A Melibiase_C PF17801.1 EMD68361.1 - 2.5e-13 49.9 0.2 7.8e-13 48.3 0.2 1.9 1 0 0 1 1 1 1 Alpha galactosidase C-terminal beta sandwich domain Melibiase PF02065.18 EMD68361.1 - 0.00043 19.3 0.0 0.00073 18.6 0.0 1.3 1 0 0 1 1 1 1 Melibiase Sugar_tr PF00083.24 EMD68362.1 - 6.4e-82 275.8 30.4 7.5e-82 275.6 30.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD68362.1 - 4.3e-15 55.5 34.4 6.1e-11 41.8 12.7 2.7 1 1 1 2 2 2 2 Major Facilitator Superfamily adh_short PF00106.25 EMD68363.1 - 4.1e-48 163.4 0.0 5.3e-48 163.1 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD68363.1 - 3.7e-36 124.9 0.0 4.8e-36 124.5 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD68363.1 - 3.6e-11 43.3 0.0 5.8e-11 42.6 0.0 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EMD68363.1 - 0.0065 16.0 0.0 0.0097 15.4 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EMD68363.1 - 0.03 13.3 0.1 0.041 12.9 0.1 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family 3HCDH_N PF02737.18 EMD68363.1 - 0.034 14.0 0.1 0.057 13.3 0.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Rv2175c_C PF18367.1 EMD68363.1 - 0.036 14.1 0.0 0.081 13.0 0.0 1.5 1 0 0 1 1 1 0 Rv2175c C-terminal domain of unknown function Polysacc_synt_2 PF02719.15 EMD68363.1 - 0.044 12.9 0.0 0.066 12.3 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Tannase PF07519.11 EMD68364.1 - 4.3e-92 309.5 0.2 5.4e-92 309.1 0.2 1.1 1 0 0 1 1 1 1 Tannase and feruloyl esterase Peptidase_S9 PF00326.21 EMD68364.1 - 6.9e-05 22.4 0.4 0.03 13.8 0.4 2.6 2 1 0 2 2 2 2 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 EMD68364.1 - 0.00045 19.6 0.0 0.0073 15.6 0.0 2.1 2 0 0 2 2 2 1 Serine aminopeptidase, S33 MOZART1 PF12554.8 EMD68364.1 - 0.11 12.3 0.0 0.33 10.8 0.0 1.7 2 0 0 2 2 2 0 Mitotic-spindle organizing gamma-tubulin ring associated F-box PF00646.33 EMD68365.1 - 0.00013 21.7 0.2 0.00027 20.7 0.2 1.5 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 EMD68365.1 - 0.00028 20.8 0.1 0.00053 19.8 0.1 1.4 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EMD68365.1 - 0.0004 20.2 0.6 0.00069 19.5 0.6 1.4 1 0 0 1 1 1 1 F-box-like adh_short_C2 PF13561.6 EMD68366.1 - 5e-37 127.7 0.8 9e-37 126.9 0.8 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EMD68366.1 - 5.2e-35 120.7 0.7 2.2e-34 118.6 0.2 2.0 2 0 0 2 2 2 1 short chain dehydrogenase Acyl_transf_1 PF00698.21 EMD68366.1 - 1e-17 64.7 0.1 9e-13 48.4 0.0 2.5 2 1 1 3 3 3 2 Acyl transferase domain KR PF08659.10 EMD68366.1 - 1.3e-11 44.7 0.3 3.4e-11 43.4 0.3 1.6 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EMD68366.1 - 0.0077 15.7 0.2 0.049 13.1 0.2 2.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EMD68366.1 - 0.025 13.6 0.0 0.042 12.9 0.0 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Med5 PF08689.10 EMD68367.1 - 4e-205 683.9 0.0 7.6e-204 679.7 0.0 2.3 1 1 0 1 1 1 1 Mediator complex subunit Med5 ABATE PF07336.11 EMD68367.1 - 0.035 14.8 1.0 2.3 8.9 1.1 3.3 2 1 0 2 2 2 0 Putative stress-induced transcription regulator Aldo_ket_red PF00248.21 EMD68370.1 - 2e-34 119.1 0.1 2.9e-32 112.0 0.1 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family ELFV_dehydrog PF00208.21 EMD68371.1 - 1.5e-83 280.3 1.5 1.8e-83 280.0 1.5 1.1 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ELFV_dehydrog_N PF02812.18 EMD68371.1 - 1.1e-49 167.7 0.0 2.2e-49 166.6 0.0 1.6 1 0 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain Pyr_redox_3 PF13738.6 EMD68371.1 - 0.11 11.7 0.0 0.17 11.1 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Helo_like_N PF17111.5 EMD68372.1 - 8.4e-05 22.0 4.8 8.4e-05 22.0 4.8 2.1 1 1 1 2 2 2 1 Fungal N-terminal domain of STAND proteins PSP1 PF04468.12 EMD68372.1 - 0.0094 16.2 1.9 0.048 13.9 0.5 2.3 2 0 0 2 2 2 1 PSP1 C-terminal conserved region Trypsin_2 PF13365.6 EMD68372.1 - 0.11 13.4 0.0 0.19 12.6 0.0 1.4 1 0 0 1 1 1 0 Trypsin-like peptidase domain Baculo_LEF5 PF04838.12 EMD68372.1 - 0.42 10.6 2.2 0.58 10.2 0.5 2.0 3 0 0 3 3 3 0 Baculoviridae late expression factor 5 ALMT PF11744.8 EMD68372.1 - 2.9 6.6 5.8 4.3 6.0 5.8 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter CorA PF01544.18 EMD68372.1 - 8.9 5.5 7.4 7.7 5.7 4.9 1.9 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein DUF3439 PF11921.8 EMD68373.1 - 0.84 9.6 9.0 2 8.4 9.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) adh_short_C2 PF13561.6 EMD68374.1 - 2e-55 187.9 0.0 2.6e-55 187.5 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EMD68374.1 - 6.5e-44 149.7 0.0 8.2e-44 149.4 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EMD68374.1 - 2.3e-09 37.4 0.0 3.3e-09 36.9 0.0 1.2 1 0 0 1 1 1 1 KR domain 2-Hacid_dh_C PF02826.19 EMD68374.1 - 0.11 11.9 0.1 4.3 6.7 0.1 2.1 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Mucin PF01456.17 EMD68375.1 - 1 9.4 15.9 1.3 9.0 15.9 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein Coa1 PF08695.10 EMD68376.1 - 7.3e-40 135.4 0.0 9.1e-40 135.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome oxidase complex assembly protein 1 Neurensin PF14927.6 EMD68377.1 - 0.22 11.2 0.6 0.81 9.4 0.0 2.1 1 1 1 2 2 2 0 Neurensin DUF308 PF03729.13 EMD68377.1 - 0.31 11.4 8.3 2.3 8.6 0.1 2.7 2 1 0 2 2 2 0 Short repeat of unknown function (DUF308) DUF997 PF06196.12 EMD68377.1 - 0.85 9.7 5.2 1.2 9.2 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF997) DUF981 PF06168.11 EMD68377.1 - 0.87 9.5 8.0 1.3 8.9 8.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF981) PHD PF00628.29 EMD68378.1 - 7.4e-08 32.2 6.3 7.4e-08 32.2 6.3 1.8 2 0 0 2 2 2 1 PHD-finger Forkhead PF00250.18 EMD68378.1 - 0.0028 17.9 0.0 0.0064 16.7 0.0 1.6 1 0 0 1 1 1 1 Forkhead domain zf-PHD-like PF15446.6 EMD68378.1 - 0.0039 16.8 3.6 0.0073 15.9 1.1 2.5 1 1 1 2 2 2 1 PHD/FYVE-zinc-finger like domain PHD_2 PF13831.6 EMD68378.1 - 0.0073 15.8 1.8 0.016 14.8 1.8 1.6 1 0 0 1 1 1 1 PHD-finger C1_1 PF00130.22 EMD68378.1 - 0.014 15.2 1.5 0.014 15.2 1.5 2.3 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Zf_RING PF16744.5 EMD68378.1 - 0.28 11.3 3.5 0.68 10.1 3.5 1.6 1 0 0 1 1 1 0 KIAA1045 RING finger Prok-RING_1 PF14446.6 EMD68378.1 - 0.28 11.1 3.2 0.61 10.1 3.2 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 PHD_4 PF16866.5 EMD68378.1 - 1.1 9.3 7.3 0.96 9.6 4.9 2.2 2 0 0 2 2 2 0 PHD-finger Pkinase PF00069.25 EMD68379.1 - 5.2e-14 52.3 0.0 2.3e-13 50.1 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD68379.1 - 5.6e-09 35.6 0.0 9.6e-09 34.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase HEAT PF02985.22 EMD68379.1 - 6e-08 32.3 2.1 0.2 12.0 0.0 4.8 4 0 0 4 4 4 2 HEAT repeat Cnd1 PF12717.7 EMD68379.1 - 1.6e-06 28.3 0.0 3e-05 24.1 0.0 2.2 1 1 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 Kinase-like PF14531.6 EMD68379.1 - 9.3e-05 21.9 0.0 0.00017 21.0 0.0 1.3 1 0 0 1 1 1 1 Kinase-like HEAT_2 PF13646.6 EMD68379.1 - 0.0001 22.6 2.4 0.0041 17.5 0.7 3.4 2 1 1 3 3 3 2 HEAT repeats HEAT_EZ PF13513.6 EMD68379.1 - 0.0021 18.5 0.5 5.9 7.5 0.5 3.3 3 0 0 3 3 3 2 HEAT-like repeat Vac14_Fab1_bd PF12755.7 EMD68379.1 - 0.041 14.5 0.1 20 5.8 0.1 3.0 2 1 1 3 3 3 0 Vacuolar 14 Fab1-binding region Aim19 PF10315.9 EMD68380.1 - 2.9e-06 27.6 0.1 3.4e-06 27.3 0.1 1.3 1 0 0 1 1 1 1 Altered inheritance of mitochondria protein 19 DUF1977 PF09320.11 EMD68381.1 - 2.5e-27 95.2 2.7 4e-27 94.5 2.7 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1977) DnaJ PF00226.31 EMD68381.1 - 3.6e-21 75.0 0.9 3.6e-21 75.0 0.9 1.8 2 0 0 2 2 2 1 DnaJ domain RbsD_FucU PF05025.13 EMD68381.1 - 0.19 12.1 0.0 0.32 11.4 0.0 1.3 1 0 0 1 1 1 0 RbsD / FucU transport protein family Cyto_heme_lyase PF01265.17 EMD68382.1 - 9.6e-45 153.4 11.0 3.8e-43 148.2 11.0 2.6 1 1 0 1 1 1 1 Cytochrome c/c1 heme lyase MDD_C PF18376.1 EMD68383.1 - 2.1e-66 223.2 0.1 2.8e-66 222.9 0.1 1.1 1 0 0 1 1 1 1 Mevalonate 5-diphosphate decarboxylase C-terminal domain GHMP_kinases_N PF00288.26 EMD68383.1 - 3e-09 37.0 0.9 8e-09 35.6 0.9 1.8 1 0 0 1 1 1 1 GHMP kinases N terminal domain Syntaxin_2 PF14523.6 EMD68384.1 - 1e-23 83.6 12.8 1.8e-23 82.8 5.0 2.4 2 1 0 2 2 2 1 Syntaxin-like protein SNARE PF05739.19 EMD68384.1 - 2e-14 53.3 2.3 4e-14 52.3 1.3 2.1 2 0 0 2 2 2 1 SNARE domain Syntaxin PF00804.25 EMD68384.1 - 9.5e-07 28.7 18.8 3.8e-05 23.4 18.8 2.7 1 1 0 1 1 1 1 Syntaxin Synaptobrevin PF00957.21 EMD68384.1 - 0.0026 17.5 0.6 0.0026 17.5 0.6 2.6 3 0 0 3 3 3 1 Synaptobrevin Nre_C PF04895.12 EMD68384.1 - 0.0051 16.7 1.8 0.012 15.5 0.2 2.3 2 0 0 2 2 2 1 Archaeal Nre, C-terminal DUF883 PF05957.13 EMD68384.1 - 0.021 15.4 19.4 0.058 14.0 1.4 3.2 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF883) Dala_Dala_lig_C PF07478.13 EMD68384.1 - 0.043 13.3 0.8 0.066 12.7 0.8 1.3 1 0 0 1 1 1 0 D-ala D-ala ligase C-terminus TMPIT PF07851.13 EMD68384.1 - 0.14 11.4 10.6 0.082 12.1 4.9 2.0 1 1 1 2 2 2 0 TMPIT-like protein DUF1664 PF07889.12 EMD68384.1 - 0.2 11.7 5.0 9.8 6.2 0.0 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) MCPsignal PF00015.21 EMD68384.1 - 0.2 11.5 8.5 0.61 9.9 0.8 2.6 2 1 0 3 3 3 0 Methyl-accepting chemotaxis protein (MCP) signalling domain PMC2NT PF08066.12 EMD68384.1 - 0.51 11.1 4.0 0.44 11.3 0.2 2.5 2 1 0 2 2 2 0 PMC2NT (NUC016) domain Amnionless PF14828.6 EMD68384.1 - 0.86 8.4 6.7 1.5 7.6 6.6 1.6 1 1 0 1 1 1 0 Amnionless Prominin PF05478.11 EMD68384.1 - 1.7 6.5 11.5 7.4 4.4 11.4 1.9 1 1 0 1 1 1 0 Prominin Orf78 PF06024.12 EMD68384.1 - 1.8 8.9 5.6 0.35 11.2 0.4 2.3 2 1 0 2 2 2 0 Orf78 (ac78) DUF131 PF01998.17 EMD68384.1 - 4.1 7.1 5.4 10 5.9 5.4 1.6 1 0 0 1 1 1 0 Protein of unknown function DUF131 YtxH PF12732.7 EMD68384.1 - 7.6 7.1 12.4 1 9.9 1.1 3.0 3 0 0 3 3 3 0 YtxH-like protein Ndc1_Nup PF09531.10 EMD68385.1 - 1.1e-173 579.2 0.1 1.3e-173 579.1 0.1 1.0 1 0 0 1 1 1 1 Nucleoporin protein Ndc1-Nup Rootletin PF15035.6 EMD68385.1 - 0.13 12.3 0.0 0.22 11.5 0.0 1.3 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion p450 PF00067.22 EMD68386.1 - 1.9e-36 125.8 0.0 4.3e-22 78.5 0.0 2.2 1 1 1 2 2 2 2 Cytochrome P450 DUF1656 PF07869.12 EMD68387.1 - 7 6.8 13.6 2.7 8.1 0.7 3.6 4 1 1 5 5 5 0 Protein of unknown function (DUF1656) NAD_binding_8 PF13450.6 EMD68388.1 - 5.6e-10 39.3 0.3 1.2e-09 38.2 0.3 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 EMD68388.1 - 1.1e-09 38.2 0.1 1.7e-09 37.6 0.1 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Amino_oxidase PF01593.24 EMD68388.1 - 3.3e-09 36.5 0.0 1.1e-08 34.9 0.0 1.8 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase HI0933_like PF03486.14 EMD68388.1 - 6.1e-06 25.2 1.7 5.8e-05 22.0 0.7 2.0 2 0 0 2 2 2 1 HI0933-like protein FAD_binding_2 PF00890.24 EMD68388.1 - 6.2e-06 25.5 4.0 1.1e-05 24.7 4.0 1.4 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.27 EMD68388.1 - 0.00011 22.7 0.3 0.0013 19.2 0.1 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EMD68388.1 - 0.00011 21.5 1.2 0.00056 19.2 0.3 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EMD68388.1 - 0.00016 21.0 0.6 0.00028 20.2 0.6 1.2 1 0 0 1 1 1 1 Thi4 family FAD_binding_3 PF01494.19 EMD68388.1 - 0.0017 17.7 0.8 0.0026 17.1 0.4 1.4 2 0 0 2 2 2 1 FAD binding domain GIDA PF01134.22 EMD68388.1 - 0.0019 17.4 0.2 0.0032 16.6 0.2 1.4 1 0 0 1 1 1 1 Glucose inhibited division protein A Pyr_redox_3 PF13738.6 EMD68388.1 - 0.0033 16.7 0.4 0.0078 15.5 0.0 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EMD68388.1 - 0.0052 16.4 2.9 0.0052 16.4 2.9 1.7 2 0 0 2 2 2 1 FAD dependent oxidoreductase Zn_clus PF00172.18 EMD68389.1 - 3.3e-09 36.7 9.4 7.7e-09 35.5 9.4 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain AflR PF08493.10 EMD68389.1 - 0.00043 19.8 7.1 0.0012 18.4 7.1 1.7 1 1 0 1 1 1 1 Aflatoxin regulatory protein NAD_binding_10 PF13460.6 EMD68390.1 - 1.7e-14 54.1 0.0 1.1e-13 51.5 0.0 2.0 2 0 0 2 2 2 1 NAD(P)H-binding NmrA PF05368.13 EMD68390.1 - 2.6e-14 53.4 0.0 1.5e-11 44.3 0.0 2.1 2 0 0 2 2 2 2 NmrA-like family Epimerase PF01370.21 EMD68390.1 - 7.5e-06 25.6 0.0 2.6e-05 23.8 0.0 1.8 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family YjeF_N PF03853.15 EMD68390.1 - 0.17 11.8 0.0 0.35 10.7 0.0 1.6 1 1 0 1 1 1 0 YjeF-related protein N-terminus FAD_binding_3 PF01494.19 EMD68391.1 - 9.3e-15 54.7 0.1 7.8e-14 51.7 0.1 2.1 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.24 EMD68391.1 - 1.2e-12 48.1 0.1 4.5e-05 23.2 0.0 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EMD68391.1 - 2.4e-10 40.2 0.1 0.00044 19.6 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EMD68391.1 - 1e-07 31.0 0.0 0.00016 20.5 0.0 2.1 2 0 0 2 2 2 2 HI0933-like protein FAD_binding_2 PF00890.24 EMD68391.1 - 4.7e-07 29.2 0.1 1e-06 28.1 0.0 1.6 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 EMD68391.1 - 4.2e-06 26.9 0.1 1e-05 25.7 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 EMD68391.1 - 1.1e-05 24.6 0.1 9.2e-05 21.6 0.1 2.0 1 1 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_3 PF13738.6 EMD68391.1 - 2.7e-05 23.6 0.0 0.0031 16.8 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EMD68391.1 - 0.00045 19.4 0.0 0.0092 15.1 0.1 2.2 2 0 0 2 2 2 1 Glucose inhibited division protein A FAD_oxidored PF12831.7 EMD68391.1 - 0.00059 19.3 0.0 0.0012 18.3 0.0 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase Amino_oxidase PF01593.24 EMD68391.1 - 0.0014 18.0 0.0 0.75 9.0 0.0 2.7 3 0 0 3 3 3 2 Flavin containing amine oxidoreductase Pyr_redox PF00070.27 EMD68391.1 - 0.0021 18.6 0.1 0.13 12.9 0.1 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 EMD68391.1 - 0.028 13.7 0.0 0.047 13.0 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_9 PF13454.6 EMD68391.1 - 0.24 11.4 1.4 1.9 8.4 0.3 2.7 2 1 0 2 2 2 0 FAD-NAD(P)-binding NmrA PF05368.13 EMD68392.1 - 1.3e-10 41.3 0.1 1.8e-10 40.8 0.1 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EMD68392.1 - 4e-08 33.4 0.1 6e-08 32.8 0.1 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EMD68392.1 - 0.0016 17.9 0.0 0.0036 16.8 0.0 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family adh_short PF00106.25 EMD68392.1 - 0.0033 16.9 0.1 0.0054 16.2 0.1 1.4 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD68392.1 - 0.024 14.2 0.1 0.037 13.6 0.1 1.2 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD68392.1 - 0.08 12.8 0.1 0.21 11.5 0.1 1.7 2 1 0 2 2 2 0 KR domain Epimerase PF01370.21 EMD68393.1 - 6.4e-09 35.6 0.0 1.2e-08 34.7 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EMD68393.1 - 1.9e-07 30.4 0.0 2.8e-07 29.8 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 EMD68393.1 - 8.7e-07 28.4 0.0 0.0083 15.3 0.0 2.2 2 0 0 2 2 2 2 Male sterility protein NmrA PF05368.13 EMD68393.1 - 7e-06 25.8 0.0 9.8e-06 25.3 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family GDP_Man_Dehyd PF16363.5 EMD68393.1 - 0.00086 18.8 0.0 0.0014 18.1 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Methyltransf_2 PF00891.18 EMD68394.1 - 4e-30 104.7 0.0 8.9e-30 103.6 0.0 1.5 2 0 0 2 2 2 1 O-methyltransferase domain Methyltransf_25 PF13649.6 EMD68394.1 - 0.0045 17.7 0.0 0.011 16.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMD68394.1 - 0.0094 16.7 0.0 0.044 14.5 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 EMD68394.1 - 0.12 11.9 0.0 0.23 11.0 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_16 PF10294.9 EMD68394.1 - 0.15 11.8 0.0 0.26 11.0 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase ketoacyl-synt PF00109.26 EMD68395.1 - 1.9e-78 263.5 0.0 3.8e-78 262.6 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain SAT PF16073.5 EMD68395.1 - 4.3e-68 229.6 0.3 1.8e-67 227.6 0.0 2.3 3 0 0 3 3 3 1 Starter unit:ACP transacylase in aflatoxin biosynthesis Acyl_transf_1 PF00698.21 EMD68395.1 - 9.4e-45 153.5 0.0 4e-44 151.4 0.0 2.0 2 0 0 2 2 2 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EMD68395.1 - 1.5e-32 112.1 0.4 3.2e-32 111.0 0.4 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain NAD_binding_4 PF07993.12 EMD68395.1 - 1.8e-23 83.0 0.0 3.7e-23 82.0 0.0 1.5 1 0 0 1 1 1 1 Male sterility protein PP-binding PF00550.25 EMD68395.1 - 1.6e-22 79.7 6.5 3.2e-10 40.2 0.8 3.4 3 0 0 3 3 3 2 Phosphopantetheine attachment site PS-DH PF14765.6 EMD68395.1 - 1.8e-12 47.1 0.0 3.5e-12 46.2 0.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase KAsynt_C_assoc PF16197.5 EMD68395.1 - 1.4e-06 28.7 0.1 4.1e-06 27.2 0.1 1.8 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Thiolase_N PF00108.23 EMD68395.1 - 2.4e-05 23.8 0.0 5.7e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 Thiolase, N-terminal domain KR PF08659.10 EMD68395.1 - 3.6e-05 23.8 0.0 0.0002 21.3 0.0 2.2 2 0 0 2 2 2 1 KR domain Epimerase PF01370.21 EMD68395.1 - 0.0014 18.1 0.0 0.0028 17.2 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EMD68395.1 - 0.038 13.1 0.0 0.068 12.3 0.0 1.4 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein B12D PF06522.11 EMD68395.1 - 0.062 13.1 0.0 0.18 11.6 0.0 1.7 1 0 0 1 1 1 0 NADH-ubiquinone reductase complex 1 MLRQ subunit Glu_dehyd_C PF16912.5 EMD68395.1 - 0.094 12.2 0.0 4.9 6.6 0.0 3.1 4 0 0 4 4 4 0 Glucose dehydrogenase C-terminus Asp PF00026.23 EMD68396.1 - 1.9e-66 224.6 0.9 2.4e-66 224.3 0.9 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EMD68396.1 - 1.1e-08 35.6 6.4 2.1e-08 34.6 0.9 3.1 3 1 0 3 3 3 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EMD68396.1 - 0.0015 19.1 0.7 3.6 8.3 0.0 3.1 3 1 0 3 3 3 2 Aspartyl protease gag-asp_proteas PF13975.6 EMD68396.1 - 0.0037 17.8 1.0 1 10.0 0.0 3.0 3 0 0 3 3 3 2 gag-polyprotein putative aspartyl protease Ras PF00071.22 EMD68397.1 - 4.8e-55 185.6 0.0 5.7e-55 185.3 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMD68397.1 - 7.1e-22 77.9 0.0 1.2e-21 77.2 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMD68397.1 - 8.1e-07 28.6 0.0 1.3e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EMD68397.1 - 0.00087 18.8 0.0 0.0013 18.2 0.0 1.4 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit NB-ARC PF00931.22 EMD68397.1 - 0.036 13.3 0.1 0.34 10.1 0.0 2.0 1 1 1 2 2 2 0 NB-ARC domain PduV-EutP PF10662.9 EMD68397.1 - 0.037 13.8 0.1 5 6.9 0.0 2.4 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Gtr1_RagA PF04670.12 EMD68397.1 - 0.16 11.3 0.0 0.19 11.1 0.0 1.4 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region Ufd2P_core PF10408.9 EMD68398.1 - 2.6e-221 736.6 8.1 3.1e-221 736.3 8.1 1.1 1 0 0 1 1 1 1 Ubiquitin elongating factor core U-box PF04564.15 EMD68398.1 - 3.5e-24 84.8 0.9 1e-23 83.3 0.9 1.8 1 0 0 1 1 1 1 U-box domain FlxA PF14282.6 EMD68398.1 - 0.0083 16.1 3.4 0.19 11.8 0.0 3.3 3 0 0 3 3 3 1 FlxA-like protein DUF2203 PF09969.9 EMD68398.1 - 0.093 13.5 6.3 0.2 12.4 0.4 2.9 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2203) Cob_adeno_trans PF01923.18 EMD68398.1 - 0.13 12.4 0.4 5.3 7.1 0.1 2.8 2 0 0 2 2 2 0 Cobalamin adenosyltransferase Spc24 PF08286.11 EMD68398.1 - 1.4 9.2 4.2 7.2 6.9 1.3 2.8 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 Ndc1_Nup PF09531.10 EMD68398.1 - 8 5.0 7.1 2.1 7.0 3.5 1.7 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup DUF1712 PF08217.11 EMD68399.1 - 2.4e-13 49.5 0.0 4.7e-13 48.5 0.0 1.5 1 0 0 1 1 1 1 Fungal domain of unknown function (DUF1712) Trypan_PARP PF05887.11 EMD68399.1 - 1.4 8.9 8.1 0.13 12.2 1.0 2.7 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) Formyl_trans_N PF00551.19 EMD68400.1 - 5.3e-27 94.7 0.0 6.9e-27 94.3 0.0 1.2 1 0 0 1 1 1 1 Formyl transferase Formyl_trans_C PF02911.18 EMD68400.1 - 0.0025 18.0 0.0 0.0065 16.7 0.0 1.7 1 0 0 1 1 1 1 Formyl transferase, C-terminal domain zf-C3HC4_3 PF13920.6 EMD68402.1 - 0.04 13.8 9.1 0.066 13.1 9.1 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-4CXXC_R1 PF10497.9 EMD68402.1 - 0.087 13.1 2.0 0.18 12.0 2.0 1.5 1 0 0 1 1 1 0 Zinc-finger domain of monoamine-oxidase A repressor R1 zf-RanBP PF00641.18 EMD68402.1 - 1.5 8.2 5.5 9.3 5.7 1.9 2.5 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others DZR PF12773.7 EMD68402.1 - 2.7 8.1 6.2 30 4.8 6.2 2.2 1 1 0 1 1 1 0 Double zinc ribbon EamA PF00892.20 EMD68403.1 - 5.3e-18 65.5 25.5 1.3e-09 38.4 14.8 2.2 2 0 0 2 2 2 2 EamA-like transporter family DUF3989 PF13150.6 EMD68403.1 - 0.053 13.3 0.2 0.67 9.7 0.0 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF3989) NMN_transporter PF04973.12 EMD68403.1 - 4.5 7.2 15.8 1.1 9.2 6.7 3.0 2 2 1 3 3 3 0 Nicotinamide mononucleotide transporter PNGaseA PF12222.8 EMD68404.1 - 7.6e-139 463.3 1.7 1.6e-138 462.2 1.7 1.5 1 1 0 1 1 1 1 Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A DUF1279 PF06916.13 EMD68405.1 - 6.4e-22 77.9 0.0 9.9e-22 77.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1279) Polysacc_deac_1 PF01522.21 EMD68407.1 - 5.2e-21 74.8 0.0 1.2e-20 73.6 0.0 1.7 1 0 0 1 1 1 1 Polysaccharide deacetylase Polysacc_deac_2 PF04748.13 EMD68407.1 - 0.038 13.2 0.0 0.081 12.1 0.0 1.5 1 0 0 1 1 1 0 Divergent polysaccharide deacetylase HTH_39 PF14090.6 EMD68407.1 - 0.052 13.3 0.0 0.18 11.6 0.1 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain Ribonuc_2-5A PF06479.12 EMD68407.1 - 0.065 13.4 0.0 9.7 6.4 0.0 2.2 2 0 0 2 2 2 0 Ribonuclease 2-5A Rad52_Rad22 PF04098.15 EMD68408.1 - 4.6e-59 198.7 0.0 6.8e-59 198.2 0.0 1.2 1 0 0 1 1 1 1 Rad52/22 family double-strand break repair protein WD40 PF00400.32 EMD68409.1 - 9e-20 70.7 7.2 7.1e-05 23.5 0.1 5.5 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD68409.1 - 6.1e-13 48.9 0.0 1e-08 35.4 0.0 4.5 1 1 5 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EMD68409.1 - 0.00067 19.6 0.8 0.26 11.1 0.1 3.3 2 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 EMD68409.1 - 0.0094 15.9 0.5 5.2 7.1 0.2 2.7 2 0 0 2 2 2 2 WD40-like Beta Propeller Repeat Nup160 PF11715.8 EMD68409.1 - 0.094 11.3 0.1 0.17 10.5 0.1 1.4 1 0 0 1 1 1 0 Nucleoporin Nup120/160 Cadherin_4 PF17803.1 EMD68409.1 - 0.12 13.0 1.5 0.45 11.2 0.0 2.5 3 0 0 3 3 3 0 Bacterial cadherin-like domain Guanylate_kin PF00625.21 EMD68410.1 - 1.6e-59 200.6 0.0 1.9e-59 200.4 0.0 1.0 1 0 0 1 1 1 1 Guanylate kinase AAA_16 PF13191.6 EMD68410.1 - 6.4e-05 23.4 0.1 9.8e-05 22.8 0.1 1.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.6 EMD68410.1 - 0.00025 21.2 0.1 0.0039 17.4 0.1 2.1 1 1 0 1 1 1 1 AAA domain ABC_tran PF00005.27 EMD68410.1 - 0.00059 20.4 0.0 0.0007 20.1 0.0 1.4 1 1 0 1 1 1 1 ABC transporter AAA_18 PF13238.6 EMD68410.1 - 0.00063 20.3 0.1 0.0025 18.3 0.1 2.0 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EMD68410.1 - 0.0011 19.2 0.0 0.0025 18.1 0.0 1.6 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 EMD68410.1 - 0.0023 17.9 0.0 0.0035 17.3 0.0 1.3 1 0 0 1 1 1 1 RsgA GTPase MMR_HSR1 PF01926.23 EMD68410.1 - 0.0039 17.3 0.0 0.0063 16.6 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF2075 PF09848.9 EMD68410.1 - 0.0042 16.4 0.0 0.034 13.4 0.0 2.0 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_29 PF13555.6 EMD68410.1 - 0.0057 16.4 0.1 0.011 15.5 0.1 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain RNA_helicase PF00910.22 EMD68410.1 - 0.0074 16.7 0.0 0.012 16.0 0.0 1.5 1 0 0 1 1 1 1 RNA helicase AAA_28 PF13521.6 EMD68410.1 - 0.0085 16.3 0.1 0.023 14.9 0.0 1.8 2 0 0 2 2 2 1 AAA domain Thymidylate_kin PF02223.17 EMD68410.1 - 0.009 15.7 1.1 1.4 8.6 0.0 2.5 1 1 1 2 2 2 1 Thymidylate kinase AAA_7 PF12775.7 EMD68410.1 - 0.01 15.4 0.0 0.016 14.7 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region T2SSE PF00437.20 EMD68410.1 - 0.011 14.8 0.0 0.023 13.8 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein Rad17 PF03215.15 EMD68410.1 - 0.013 15.5 0.0 0.018 15.0 0.0 1.2 1 0 0 1 1 1 0 Rad17 P-loop domain dNK PF01712.19 EMD68410.1 - 0.013 15.3 0.1 0.58 10.0 0.0 2.3 2 0 0 2 2 2 0 Deoxynucleoside kinase NTPase_1 PF03266.15 EMD68410.1 - 0.019 14.8 0.0 0.031 14.2 0.0 1.4 1 0 0 1 1 1 0 NTPase AAA_23 PF13476.6 EMD68410.1 - 0.024 15.2 1.2 0.043 14.3 0.0 1.8 2 1 0 2 2 2 0 AAA domain cobW PF02492.19 EMD68410.1 - 0.03 13.9 0.0 0.32 10.6 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_17 PF13207.6 EMD68410.1 - 0.03 14.7 0.1 0.5 10.8 0.0 2.2 2 0 0 2 2 2 0 AAA domain Cytidylate_kin PF02224.18 EMD68410.1 - 0.038 13.7 0.7 0.4 10.4 0.1 2.4 2 1 1 3 3 3 0 Cytidylate kinase AAA_30 PF13604.6 EMD68410.1 - 0.04 13.6 0.1 0.11 12.2 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.6 EMD68410.1 - 0.046 13.8 0.0 0.085 12.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EMD68410.1 - 0.1 12.3 0.0 0.21 11.3 0.0 1.7 2 0 0 2 2 2 0 AAA domain WD40 PF00400.32 EMD68411.1 - 5.5e-22 77.7 7.6 2.2e-06 28.3 0.6 6.9 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD68411.1 - 9.6e-12 45.0 0.7 0.00048 20.4 0.1 4.5 1 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EMD68411.1 - 0.00039 19.8 0.0 4.3 6.6 0.0 3.4 3 1 0 3 3 3 3 WD40-like domain eIF2A PF08662.11 EMD68411.1 - 0.017 15.0 0.0 0.16 11.9 0.0 2.2 1 1 1 2 2 2 0 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 EMD68411.1 - 0.032 12.9 0.0 0.65 8.6 0.0 2.1 2 0 0 2 2 2 0 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 EMD68411.1 - 0.16 10.9 0.0 1.4 7.8 0.0 2.3 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein R2K_3 PF14243.6 EMD68412.1 - 0.1 12.6 0.0 1.6 8.7 0.0 2.4 1 1 1 2 2 2 0 ATP-grasp domain, R2K clade family 3 Peptidase_S8 PF00082.22 EMD68413.1 - 8.1e-34 117.2 10.8 1.6e-33 116.2 10.8 1.5 1 1 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 EMD68413.1 - 0.15 12.8 0.0 0.25 12.0 0.0 1.4 1 0 0 1 1 1 0 Peptidase inhibitor I9 Pec_lyase_C PF00544.19 EMD68414.1 - 7.2e-39 133.6 6.0 1e-38 133.1 6.0 1.2 1 0 0 1 1 1 1 Pectate lyase Beta_helix PF13229.6 EMD68414.1 - 3.7e-05 23.6 10.2 0.0012 18.7 9.8 2.4 1 1 1 2 2 2 2 Right handed beta helix region MRP-S25 PF13741.6 EMD68415.1 - 9.5e-68 228.2 1.4 3.3e-61 206.8 0.8 2.1 1 1 1 2 2 2 2 Mitochondrial ribosomal protein S25 MRP-S23 PF10484.9 EMD68415.1 - 0.0013 19.0 0.7 0.0027 17.9 0.2 2.0 2 1 0 2 2 2 1 Mitochondrial ribosomal protein S23 PPR_2 PF13041.6 EMD68416.1 - 3.1e-12 46.5 0.3 0.00048 20.3 0.0 4.8 5 0 0 5 5 5 3 PPR repeat family PPR PF01535.20 EMD68416.1 - 1.9e-10 40.2 0.0 0.012 15.8 0.0 4.7 4 0 0 4 4 4 2 PPR repeat PPR_3 PF13812.6 EMD68416.1 - 6.6e-06 26.1 0.0 0.35 11.0 0.0 3.9 4 0 0 4 4 4 2 Pentatricopeptide repeat domain PPR_long PF17177.4 EMD68416.1 - 0.024 14.0 0.5 0.1 12.0 0.2 2.2 3 0 0 3 3 3 0 Pentacotripeptide-repeat region of PRORP PPR_1 PF12854.7 EMD68416.1 - 0.065 12.9 0.1 21 4.9 0.0 3.7 4 0 0 4 4 4 0 PPR repeat OTOS PF15182.6 EMD68418.1 - 0.095 12.6 0.3 0.29 11.1 0.0 1.9 3 0 0 3 3 3 0 Otospiralin BTB PF00651.31 EMD68419.1 - 0.00033 20.8 0.0 0.00056 20.1 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain BTB PF00651.31 EMD68420.1 - 0.0001 22.5 0.1 0.00018 21.7 0.1 1.4 1 0 0 1 1 1 1 BTB/POZ domain RRM_1 PF00076.22 EMD68421.1 - 1.1e-15 57.2 0.3 1.9e-15 56.5 0.0 1.5 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) EMP24_GP25L PF01105.24 EMD68421.1 - 0.073 13.0 6.1 0.11 12.5 6.1 1.1 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD CCDC71L PF15374.6 EMD68421.1 - 0.48 9.6 1.9 0.6 9.3 1.9 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 71L Band_3_cyto PF07565.13 EMD68421.1 - 0.49 10.2 2.7 0.61 9.8 2.7 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain V_ATPase_I PF01496.19 EMD68421.1 - 0.5 8.2 3.9 0.57 8.0 3.9 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF724 PF05266.14 EMD68421.1 - 0.84 9.4 10.4 1.1 9.1 10.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF724) TRAP_alpha PF03896.16 EMD68421.1 - 4.6 6.3 5.6 6.1 6.0 5.6 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit UPF0242 PF06785.11 EMD68421.1 - 7.3 6.6 8.4 11 6.1 8.4 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus UQ_con PF00179.26 EMD68422.1 - 3.6e-48 162.8 0.0 4.1e-48 162.6 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EMD68422.1 - 0.00023 20.9 0.0 0.00029 20.6 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 EMD68422.1 - 0.0061 16.8 0.7 0.016 15.5 0.7 1.7 1 1 0 1 1 1 1 RWD domain Pex19 PF04614.12 EMD68423.1 - 1.8e-74 250.6 21.8 3.1e-74 249.9 21.8 1.3 1 0 0 1 1 1 1 Pex19 protein family ABC_tran_Xtn PF12848.7 EMD68423.1 - 0.036 14.1 0.6 0.036 14.1 0.6 3.2 3 0 0 3 3 3 0 ABC transporter NB-LRR PF12061.8 EMD68423.1 - 0.071 12.4 0.1 0.15 11.4 0.1 1.4 1 0 0 1 1 1 0 Late blight resistance protein R1 GCP_C_terminal PF04130.13 EMD68423.1 - 0.17 11.3 2.6 0.44 10.0 2.6 1.6 1 1 0 1 1 1 0 Gamma tubulin complex component C-terminal HATPase_c PF02518.26 EMD68425.1 - 5.7e-22 78.3 0.1 1.5e-21 77.0 0.1 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EMD68425.1 - 1.1e-21 77.1 0.1 2.6e-21 75.9 0.1 1.7 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 EMD68425.1 - 1.2e-12 47.7 0.0 6.5e-12 45.3 0.0 2.3 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain FMO-like PF00743.19 EMD68426.1 - 3.2e-11 42.4 0.2 5e-10 38.4 0.2 2.5 1 1 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 EMD68426.1 - 5.2e-11 42.3 0.0 5.3e-09 35.7 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EMD68426.1 - 1.6e-10 41.1 0.0 1.5e-08 34.8 0.0 3.1 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 EMD68426.1 - 7.4e-10 38.6 0.0 2e-09 37.2 0.0 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EMD68426.1 - 5.5e-07 29.5 0.0 0.0001 22.0 0.0 2.7 3 0 0 3 3 3 1 FAD dependent oxidoreductase Thi4 PF01946.17 EMD68426.1 - 8.5e-07 28.5 0.0 7.1e-06 25.4 0.0 2.1 2 0 0 2 2 2 1 Thi4 family K_oxygenase PF13434.6 EMD68426.1 - 8.9e-05 21.8 0.2 0.0044 16.2 0.0 2.6 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) FAD_oxidored PF12831.7 EMD68426.1 - 0.00066 19.1 0.0 0.018 14.4 0.0 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EMD68426.1 - 0.0048 16.9 2.5 0.25 11.3 0.0 3.2 3 0 0 3 3 3 1 FAD-NAD(P)-binding Lycopene_cycl PF05834.12 EMD68426.1 - 0.0067 15.5 0.0 0.11 11.5 0.0 2.5 3 0 0 3 3 3 1 Lycopene cyclase protein GIDA PF01134.22 EMD68426.1 - 0.0076 15.4 0.2 0.68 8.9 0.0 2.1 2 0 0 2 2 2 1 Glucose inhibited division protein A FAD_binding_2 PF00890.24 EMD68426.1 - 0.0098 15.0 0.0 0.022 13.9 0.0 1.6 2 0 0 2 2 2 1 FAD binding domain Mqo PF06039.15 EMD68426.1 - 0.012 14.3 0.0 3.6 6.0 0.0 2.3 2 0 0 2 2 2 0 Malate:quinone oxidoreductase (Mqo) Pyr_redox PF00070.27 EMD68426.1 - 0.019 15.5 0.0 2.6 8.7 0.0 2.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 EMD68426.1 - 0.021 14.1 0.0 0.037 13.3 0.0 1.5 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase Shikimate_DH PF01488.20 EMD68426.1 - 0.029 14.4 0.0 0.19 11.8 0.0 2.1 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase MFS_1 PF07690.16 EMD68427.1 - 9e-29 100.5 38.5 3.8e-20 72.1 21.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EMD68427.1 - 9e-15 54.5 23.2 3.7e-11 42.6 4.6 3.0 2 1 1 3 3 3 3 Sugar (and other) transporter ABC2_membrane_5 PF13346.6 EMD68427.1 - 1.8 8.0 12.0 0.1 12.2 2.5 3.0 3 0 0 3 3 3 0 ABC-2 family transporter protein Fungal_trans PF04082.18 EMD68428.1 - 9.3e-10 38.0 0.7 1.6e-09 37.2 0.7 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Sugar_tr PF00083.24 EMD68429.1 - 3.9e-47 161.2 14.1 5.1e-47 160.8 14.1 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD68429.1 - 2.6e-19 69.4 19.0 2.6e-19 69.4 19.0 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily SBBP PF06739.11 EMD68430.1 - 0.0045 17.0 0.0 0.49 10.4 0.0 3.4 3 0 0 3 3 3 1 Beta-propeller repeat Lactonase PF10282.9 EMD68430.1 - 0.12 11.6 0.0 1.1 8.4 0.0 2.0 2 0 0 2 2 2 0 Lactonase, 7-bladed beta-propeller ECH_1 PF00378.20 EMD68431.1 - 3e-25 89.0 0.0 3.6e-25 88.7 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EMD68431.1 - 1.9e-12 47.4 0.0 2.2e-12 47.2 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Glyco_hydro_6 PF01341.17 EMD68432.1 - 2.2e-99 333.1 0.1 2.7e-99 332.7 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 6 Fungal_trans PF04082.18 EMD68433.1 - 3.9e-19 68.7 0.2 6.6e-19 68.0 0.2 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD68433.1 - 6.6e-08 32.5 7.8 1.3e-07 31.6 7.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SUR7 PF06687.12 EMD68434.1 - 4.1e-05 23.3 1.1 5.3e-05 22.9 1.1 1.3 1 0 0 1 1 1 1 SUR7/PalI family Peptidase_C98 PF15499.6 EMD68434.1 - 0.09 12.2 0.0 0.13 11.8 0.0 1.2 1 0 0 1 1 1 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase FA_desaturase PF00487.24 EMD68435.1 - 1e-25 91.0 14.3 1.5e-25 90.5 14.3 1.2 1 0 0 1 1 1 1 Fatty acid desaturase Lipid_DES PF08557.10 EMD68435.1 - 1.7e-17 62.6 0.9 3.1e-17 61.8 0.9 1.4 1 0 0 1 1 1 1 Sphingolipid Delta4-desaturase (DES) PPP4R2 PF09184.11 EMD68436.1 - 0.55 9.8 14.8 0.82 9.2 14.8 1.2 1 0 0 1 1 1 0 PPP4R2 SDA1 PF05285.12 EMD68436.1 - 6.6 6.0 20.3 8.5 5.7 20.3 1.1 1 0 0 1 1 1 0 SDA1 IKI3 PF04762.12 EMD68437.1 - 0 1022.8 0.0 0 1022.3 0.0 1.2 1 0 0 1 1 1 1 IKI3 family ANAPC4_WD40 PF12894.7 EMD68437.1 - 5.3e-05 23.4 0.3 2.8 8.3 0.0 4.3 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Phage_Nu1 PF07471.12 EMD68437.1 - 0.01 15.6 1.1 0.029 14.1 1.1 1.7 1 0 0 1 1 1 0 Phage DNA packaging protein Nu1 Gmad1 PF10647.9 EMD68437.1 - 0.016 15.0 1.0 1.6 8.4 0.0 3.1 2 1 0 2 2 2 0 Lipoprotein LpqB beta-propeller domain 7TMR-HDED PF07697.11 EMD68437.1 - 0.28 11.3 5.2 0.24 11.5 0.3 2.5 2 1 0 2 2 2 0 7TM-HD extracellular DUF1192 PF06698.11 EMD68437.1 - 7.2 6.8 7.3 1.4 9.0 1.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1192) COX7C PF02935.16 EMD68438.1 - 3.3e-25 88.1 2.4 3.9e-25 87.9 2.4 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIIc rRNA_proc-arch PF13234.6 EMD68439.1 - 7e-91 304.9 0.3 1.7e-90 303.7 0.0 1.8 2 0 0 2 2 2 1 rRNA-processing arch domain DSHCT PF08148.12 EMD68439.1 - 5.9e-56 188.7 4.2 2.8e-55 186.5 2.6 2.4 2 0 0 2 2 2 1 DSHCT (NUC185) domain DEAD PF00270.29 EMD68439.1 - 1.1e-18 67.6 1.5 3.8e-18 65.9 0.0 2.6 3 0 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EMD68439.1 - 4.9e-07 30.1 0.0 2.9e-06 27.6 0.0 2.3 1 1 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EMD68439.1 - 4e-06 26.9 0.0 1.9e-05 24.8 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DUF5388 PF17363.2 EMD68439.1 - 0.0098 16.1 0.7 0.076 13.2 0.1 2.8 2 0 0 2 2 2 1 Family of unknown function (DUF5388) T2SSE PF00437.20 EMD68439.1 - 0.021 13.9 0.0 0.047 12.7 0.0 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein ATPase_2 PF01637.18 EMD68439.1 - 0.025 14.5 0.4 0.12 12.3 0.0 2.3 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_22 PF13401.6 EMD68439.1 - 0.037 14.3 0.2 0.49 10.7 0.0 2.9 3 0 0 3 3 3 0 AAA domain DegS PF05384.11 EMD68439.1 - 9.7 5.7 9.0 5.5 6.4 0.0 3.0 3 0 0 3 3 3 0 Sensor protein DegS Cut8 PF08559.10 EMD68440.1 - 9.6e-81 270.9 0.0 1.2e-80 270.6 0.0 1.1 1 0 0 1 1 1 1 Cut8, nuclear proteasome tether protein DBD_HTH PF18430.1 EMD68440.1 - 0.41 10.5 1.8 0.84 9.5 1.8 1.5 1 0 0 1 1 1 0 Putative DNA-binding domain UTP25 PF06862.12 EMD68445.1 - 3.5e-184 613.0 0.1 4.2e-184 612.8 0.1 1.1 1 0 0 1 1 1 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 Peptidase_C26 PF07722.13 EMD68445.1 - 0.19 11.5 0.0 0.32 10.7 0.0 1.3 1 0 0 1 1 1 0 Peptidase C26 JAB PF01398.21 EMD68446.1 - 2.4e-21 75.9 0.0 3.8e-21 75.2 0.0 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 EMD68446.1 - 4e-21 75.5 1.1 7.7e-21 74.6 1.1 1.5 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function UPF0172 PF03665.13 EMD68446.1 - 4e-05 23.8 0.0 9.4e-05 22.5 0.0 1.6 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0172) FlaC_arch PF05377.11 EMD68446.1 - 0.085 13.3 0.4 0.18 12.2 0.4 1.5 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) DUF1978 PF09321.10 EMD68446.1 - 0.1 11.9 0.3 0.18 11.1 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1978) TFIID-18kDa PF02269.16 EMD68447.1 - 1.6e-24 85.7 0.1 1.6e-24 85.7 0.1 1.4 2 0 0 2 2 2 1 Transcription initiation factor IID, 18kD subunit CENP-S PF15630.6 EMD68447.1 - 5.4e-05 23.5 0.1 0.00012 22.4 0.1 1.5 2 0 0 2 2 2 1 CENP-S protein CENP-T_C PF15511.6 EMD68447.1 - 0.0037 17.3 0.3 0.0059 16.7 0.3 1.4 1 1 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TFIID-31kDa PF02291.15 EMD68447.1 - 0.017 15.2 0.0 0.023 14.8 0.0 1.2 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit Histone PF00125.24 EMD68447.1 - 0.047 14.1 0.1 0.047 14.1 0.1 2.3 2 1 0 2 2 2 0 Core histone H2A/H2B/H3/H4 Bromo_TP PF07524.13 EMD68447.1 - 0.095 12.7 0.0 0.16 12.0 0.0 1.3 1 0 0 1 1 1 0 Bromodomain associated DUF1242 PF06842.12 EMD68448.1 - 1.7e-14 53.3 0.2 2.2e-14 52.9 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1242) Protoglobin PF11563.8 EMD68450.1 - 2.3e-59 199.8 0.2 2.9e-59 199.5 0.2 1.1 1 0 0 1 1 1 1 Protoglobin NmrA PF05368.13 EMD68452.1 - 2.6e-21 76.3 0.0 3.3e-21 75.9 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EMD68452.1 - 3.2e-11 43.5 0.2 8.4e-11 42.1 0.0 1.7 2 0 0 2 2 2 1 NAD(P)H-binding Epimerase PF01370.21 EMD68452.1 - 0.00019 21.0 0.1 0.0017 17.8 0.0 2.4 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family LpxI_N PF17930.1 EMD68452.1 - 0.013 15.4 0.0 0.032 14.1 0.0 1.7 1 0 0 1 1 1 0 LpxI N-terminal domain NAD_binding_2 PF03446.15 EMD68452.1 - 0.019 15.1 0.1 0.16 12.2 0.0 2.3 2 1 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase Semialdhyde_dh PF01118.24 EMD68452.1 - 0.02 15.3 0.4 0.19 12.1 0.0 2.3 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain CBS PF00571.28 EMD68452.1 - 0.061 13.8 0.1 0.17 12.4 0.1 1.7 1 0 0 1 1 1 0 CBS domain RmlD_sub_bind PF04321.17 EMD68452.1 - 0.065 12.3 0.0 0.14 11.3 0.0 1.5 1 0 0 1 1 1 0 RmlD substrate binding domain B12-binding PF02310.19 EMD68452.1 - 0.18 11.9 0.5 0.48 10.5 0.0 1.9 2 0 0 2 2 2 0 B12 binding domain CFEM PF05730.11 EMD68453.1 - 1.3e-14 54.0 9.2 2.3e-14 53.2 9.2 1.4 1 0 0 1 1 1 1 CFEM domain DJ-1_PfpI PF01965.24 EMD68455.1 - 6.8e-18 65.0 0.0 1.4e-17 64.0 0.0 1.5 1 1 0 1 1 1 1 DJ-1/PfpI family GATase PF00117.28 EMD68455.1 - 3e-05 23.9 0.1 5.9e-05 22.9 0.0 1.5 2 0 0 2 2 2 1 Glutamine amidotransferase class-I AAA_33 PF13671.6 EMD68457.1 - 0.00012 22.3 0.1 0.00023 21.4 0.1 1.5 1 0 0 1 1 1 1 AAA domain PRK PF00485.18 EMD68457.1 - 0.00017 21.4 0.0 0.00071 19.4 0.0 1.8 2 0 0 2 2 2 1 Phosphoribulokinase / Uridine kinase family Zeta_toxin PF06414.12 EMD68457.1 - 0.00024 20.4 0.0 0.00049 19.4 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin DUF463 PF04317.12 EMD68457.1 - 0.0017 17.4 0.1 0.0041 16.1 0.1 1.7 2 0 0 2 2 2 1 YcjX-like family, DUF463 AAA_16 PF13191.6 EMD68457.1 - 0.0031 17.9 0.1 0.0053 17.2 0.1 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.6 EMD68457.1 - 0.013 16.0 0.0 0.035 14.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 EMD68457.1 - 0.016 15.1 0.0 0.029 14.3 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea MeaB PF03308.16 EMD68457.1 - 0.021 13.8 0.0 0.052 12.5 0.0 1.6 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB ABC_tran PF00005.27 EMD68457.1 - 0.024 15.2 0.0 0.042 14.4 0.0 1.4 1 0 0 1 1 1 0 ABC transporter AAA_14 PF13173.6 EMD68457.1 - 0.032 14.3 0.0 0.089 12.8 0.0 1.8 2 0 0 2 2 2 0 AAA domain KTI12 PF08433.10 EMD68457.1 - 0.039 13.4 0.0 0.062 12.7 0.0 1.3 1 0 0 1 1 1 0 Chromatin associated protein KTI12 NB-ARC PF00931.22 EMD68457.1 - 0.046 12.9 0.0 0.062 12.5 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain APS_kinase PF01583.20 EMD68457.1 - 0.066 13.1 0.1 0.12 12.3 0.1 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase NACHT PF05729.12 EMD68457.1 - 0.07 13.0 0.0 0.2 11.6 0.0 1.8 2 0 0 2 2 2 0 NACHT domain SRP54 PF00448.22 EMD68457.1 - 0.073 12.7 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain Thymidylate_kin PF02223.17 EMD68457.1 - 0.11 12.2 0.1 0.31 10.7 0.0 1.8 2 0 0 2 2 2 0 Thymidylate kinase KAP_NTPase PF07693.14 EMD68457.1 - 0.14 11.4 0.0 0.27 10.4 0.0 1.6 1 1 0 1 1 1 0 KAP family P-loop domain PRELI PF04707.14 EMD68459.1 - 7.7e-45 152.5 0.1 9.5e-45 152.2 0.1 1.1 1 0 0 1 1 1 1 PRELI-like family UPF0160 PF03690.13 EMD68460.1 - 2.1e-124 415.3 0.0 2.4e-124 415.1 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0160) ICE2 PF08426.10 EMD68461.1 - 6.4e-155 516.2 6.3 7.3e-155 516.1 6.3 1.0 1 0 0 1 1 1 1 ICE2 DUF5108 PF17133.4 EMD68461.1 - 0.11 12.4 0.0 0.22 11.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5108) Hexapep PF00132.24 EMD68462.1 - 2.8e-14 52.2 14.5 7.6e-10 38.1 4.7 3.5 2 1 1 3 3 3 3 Bacterial transferase hexapeptide (six repeats) Mac PF12464.8 EMD68462.1 - 1.3e-08 35.0 0.1 2.5e-08 34.0 0.1 1.5 1 0 0 1 1 1 1 Maltose acetyltransferase Hexapep_2 PF14602.6 EMD68462.1 - 2e-08 33.8 10.7 2e-07 30.6 3.2 2.9 3 1 0 3 3 3 2 Hexapeptide repeat of succinyl-transferase Zn_clus PF00172.18 EMD68462.1 - 3.9e-08 33.3 8.8 3.9e-08 33.3 8.8 1.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF4954 PF16314.5 EMD68462.1 - 0.39 8.8 2.2 0.6 8.2 2.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4954) Ribosomal_L3 PF00297.22 EMD68463.1 - 9.1e-16 57.8 5.2 7.8e-13 48.1 2.5 2.2 1 1 1 2 2 2 2 Ribosomal protein L3 Pec_lyase_C PF00544.19 EMD68465.1 - 6.3e-10 39.0 9.8 6.3e-10 39.0 9.8 2.4 2 1 0 2 2 2 1 Pectate lyase Beta_helix PF13229.6 EMD68465.1 - 4.8e-07 29.8 10.6 1.2e-06 28.5 10.4 1.9 1 1 0 1 1 1 1 Right handed beta helix region DUF3405 PF11885.8 EMD68466.1 - 1e-226 753.6 5.1 1.2e-226 753.3 5.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3405) Acyl-CoA_dh_1 PF00441.24 EMD68467.1 - 8.4e-31 107.2 5.2 1.6e-30 106.3 5.2 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 EMD68467.1 - 2e-21 76.0 0.0 3.9e-21 75.1 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 EMD68467.1 - 7.8e-18 65.2 0.0 2.4e-17 63.6 0.0 1.9 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 EMD68467.1 - 1.8e-14 54.2 8.6 5.1e-13 49.5 6.9 2.4 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Patatin PF01734.22 EMD68468.1 - 2.1e-21 77.0 2.3 1.7e-11 44.7 0.1 2.7 1 1 1 2 2 2 2 Patatin-like phospholipase NB-ARC PF00931.22 EMD68468.1 - 8.4e-09 35.0 0.0 1.3e-08 34.3 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain TPR_10 PF13374.6 EMD68468.1 - 7.3e-08 32.0 1.1 1.4e-05 24.8 0.2 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 EMD68468.1 - 4.5e-06 26.9 0.1 4.5e-06 26.9 0.1 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat AAA_16 PF13191.6 EMD68468.1 - 9.5e-05 22.8 4.3 0.00028 21.3 0.0 3.4 2 1 1 4 4 4 1 AAA ATPase domain PPV_E1_C PF00519.17 EMD68468.1 - 0.00094 18.1 0.2 0.0025 16.7 0.0 1.7 2 0 0 2 2 2 1 Papillomavirus helicase AAA_22 PF13401.6 EMD68468.1 - 0.1 12.9 0.0 0.59 10.4 0.0 2.3 1 0 0 1 1 1 0 AAA domain HTH_psq PF05225.16 EMD68469.1 - 1.1e-05 25.0 0.1 1.6e-05 24.5 0.1 1.3 1 0 0 1 1 1 1 helix-turn-helix, Psq domain SpoIIID PF12116.8 EMD68469.1 - 0.0047 17.0 0.0 0.0049 16.9 0.0 1.2 1 0 0 1 1 1 1 Stage III sporulation protein D HTH_7 PF02796.15 EMD68469.1 - 0.0087 16.1 0.1 0.013 15.5 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase CENP-B_N PF04218.13 EMD68469.1 - 0.016 14.8 0.0 0.027 14.1 0.0 1.4 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain HTH_23 PF13384.6 EMD68469.1 - 0.048 13.5 0.0 0.071 12.9 0.0 1.3 1 0 0 1 1 1 0 Homeodomain-like domain p450 PF00067.22 EMD68470.1 - 1.2e-57 195.7 0.0 1.6e-57 195.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 EMD68472.1 - 1.3e-11 44.0 0.0 1.1e-10 40.9 0.0 2.0 1 1 0 1 1 1 1 Cytochrome P450 WD40 PF00400.32 EMD68473.1 - 1.8e-60 199.4 33.2 1.6e-10 41.3 0.4 7.4 7 0 0 7 7 7 6 WD domain, G-beta repeat NACHT PF05729.12 EMD68473.1 - 4.3e-21 75.5 0.1 8.5e-21 74.6 0.1 1.5 1 0 0 1 1 1 1 NACHT domain ANAPC4_WD40 PF12894.7 EMD68473.1 - 5.7e-18 65.0 6.0 0.0028 17.9 0.1 6.9 2 1 5 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EMD68473.1 - 1.5e-13 50.3 21.8 0.012 14.2 0.3 6.1 1 1 5 6 6 6 6 Nucleoporin Nup120/160 HET PF06985.11 EMD68473.1 - 5.2e-13 49.6 6.2 7.5e-11 42.6 1.0 2.8 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) Ge1_WD40 PF16529.5 EMD68473.1 - 1.3e-12 47.4 17.9 3e-05 23.1 4.3 5.1 1 1 4 5 5 5 5 WD40 region of Ge1, enhancer of mRNA-decapping protein Nbas_N PF15492.6 EMD68473.1 - 0.0068 15.8 16.1 7.4 5.8 0.1 5.4 1 1 5 6 6 6 3 Neuroblastoma-amplified sequence, N terminal DUF1986 PF09342.11 EMD68473.1 - 0.37 11.2 6.8 9.9 6.6 0.1 4.9 2 1 3 5 5 5 0 Domain of unknown function (DUF1986) AATase PF07247.12 EMD68474.1 - 3.5e-16 58.8 0.0 7.7e-07 28.0 0.0 3.0 2 1 1 3 3 3 3 Alcohol acetyltransferase Abhydrolase_3 PF07859.13 EMD68475.1 - 2.3e-44 151.8 0.1 3e-44 151.4 0.1 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 EMD68475.1 - 2.1e-05 23.6 0.0 4.3e-05 22.6 0.0 1.4 1 1 0 1 1 1 1 Carboxylesterase family DIT1_PvcA PF05141.12 EMD68476.1 - 4.7e-94 314.9 0.0 9.1e-94 314.0 0.0 1.5 1 0 0 1 1 1 1 Pyoverdine/dityrosine biosynthesis protein AMP-binding PF00501.28 EMD68476.1 - 3.1e-26 92.0 0.0 5.2e-26 91.2 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme MFS_1 PF07690.16 EMD68476.1 - 1e-12 47.7 51.1 1.4e-09 37.3 36.3 3.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Transferase PF02458.15 EMD68476.1 - 3.3e-07 29.3 0.0 1.2e-05 24.2 0.0 2.7 1 1 0 1 1 1 1 Transferase family PP-binding PF00550.25 EMD68476.1 - 9e-06 26.0 0.0 2e-05 24.8 0.0 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site TRI12 PF06609.13 EMD68476.1 - 0.0091 14.5 9.8 0.0079 14.7 8.4 1.4 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) WW_1 PF18507.1 EMD68476.1 - 0.02 14.6 0.0 0.052 13.2 0.0 1.7 1 0 0 1 1 1 0 WW domain WD40 PF00400.32 EMD68477.1 - 1.2e-49 165.2 13.8 4.2e-09 36.9 0.1 7.9 7 0 0 7 7 7 7 WD domain, G-beta repeat NACHT PF05729.12 EMD68477.1 - 5.4e-25 88.2 0.1 1.1e-24 87.3 0.1 1.5 1 0 0 1 1 1 1 NACHT domain ANAPC4_WD40 PF12894.7 EMD68477.1 - 3.9e-24 84.8 0.1 0.00018 21.7 0.1 6.6 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EMD68477.1 - 5e-16 58.6 6.8 0.00012 21.2 0.6 5.7 1 1 5 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein HET PF06985.11 EMD68477.1 - 1.5e-13 51.3 9.3 1.4e-11 44.9 1.5 3.4 2 1 1 3 3 3 2 Heterokaryon incompatibility protein (HET) PD40 PF07676.12 EMD68477.1 - 1.1e-07 31.6 8.2 6.5 6.8 0.0 6.8 7 0 0 7 7 7 3 WD40-like Beta Propeller Repeat Nup160 PF11715.8 EMD68477.1 - 0.00015 20.6 4.2 0.43 9.2 0.1 3.7 3 1 2 5 5 5 2 Nucleoporin Nup120/160 Gmad1 PF10647.9 EMD68477.1 - 0.0032 17.3 1.3 0.54 10.0 0.6 3.8 1 1 1 2 2 2 1 Lipoprotein LpqB beta-propeller domain RNA_helicase PF00910.22 EMD68477.1 - 0.0068 16.8 0.1 0.39 11.1 0.0 3.5 4 0 0 4 4 4 1 RNA helicase Med11 PF10280.9 EMD68477.1 - 0.065 13.7 0.0 25 5.3 0.0 3.1 3 0 0 3 3 3 0 Mediator complex protein Ank_2 PF12796.7 EMD68478.1 - 3.8e-13 49.8 0.1 8.6e-08 32.7 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EMD68478.1 - 6e-11 41.6 0.3 0.0011 19.3 0.0 5.0 6 0 0 6 6 6 2 Ankyrin repeat Ank_4 PF13637.6 EMD68478.1 - 5.7e-07 30.0 0.0 1.8e-05 25.2 0.0 2.8 2 2 1 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 EMD68478.1 - 2.6e-05 24.4 0.0 0.0047 17.2 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 EMD68478.1 - 0.00075 19.8 0.0 0.047 14.2 0.0 3.2 3 0 0 3 3 3 1 Ankyrin repeat Ank_3 PF13606.6 EMD68479.1 - 6.4e-09 35.3 0.0 0.87 10.3 0.0 5.7 6 0 0 6 6 6 2 Ankyrin repeat Ank_2 PF12796.7 EMD68479.1 - 1.3e-08 35.3 0.0 0.00026 21.5 0.0 4.2 1 1 4 5 5 5 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EMD68479.1 - 3.7e-08 33.5 0.0 0.07 13.5 0.0 4.6 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 EMD68479.1 - 3.3e-07 30.7 0.0 0.00021 21.8 0.0 3.6 2 1 2 4 4 4 1 Ankyrin repeats (many copies) F-box-like PF12937.7 EMD68479.1 - 0.055 13.4 0.3 0.16 11.9 0.3 1.8 1 0 0 1 1 1 0 F-box-like Bromodomain PF00439.25 EMD68480.1 - 6.4e-41 138.3 8.6 5.6e-20 71.2 2.1 2.6 2 0 0 2 2 2 2 Bromodomain BAH PF01426.18 EMD68480.1 - 4.8e-18 65.2 0.8 1.2e-17 63.9 0.8 1.8 1 0 0 1 1 1 1 BAH domain CDC45 PF02724.14 EMD68480.1 - 0.051 11.9 22.2 0.026 12.9 13.6 2.2 2 0 0 2 2 2 0 CDC45-like protein RRN3 PF05327.11 EMD68480.1 - 0.16 10.5 6.5 0.36 9.3 6.5 1.6 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 OTU PF02338.19 EMD68481.1 - 3.6e-06 27.5 0.0 7e-06 26.6 0.0 1.5 1 0 0 1 1 1 1 OTU-like cysteine protease Mac PF12464.8 EMD68481.1 - 0.11 12.7 0.2 0.3 11.3 0.2 1.8 1 0 0 1 1 1 0 Maltose acetyltransferase DUF3804 PF12707.7 EMD68482.1 - 0.0044 16.7 0.0 0.0083 15.9 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3804) Zeta_toxin PF06414.12 EMD68482.1 - 0.021 14.1 0.0 0.077 12.3 0.0 1.9 2 0 0 2 2 2 0 Zeta toxin AAA_22 PF13401.6 EMD68482.1 - 0.042 14.1 0.1 8 6.7 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 EMD68482.1 - 0.068 13.6 0.1 0.33 11.4 0.0 2.0 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_10 PF12846.7 EMD68482.1 - 0.13 11.1 0.0 10 4.9 0.0 2.1 2 0 0 2 2 2 0 AAA-like domain BTB PF00651.31 EMD68483.1 - 0.074 13.3 0.0 0.091 13.0 0.0 1.3 1 0 0 1 1 1 0 BTB/POZ domain DnaJ PF00226.31 EMD68484.1 - 4.7e-23 81.1 2.2 1.9e-22 79.1 2.2 2.2 1 0 0 1 1 1 1 DnaJ domain TPR_2 PF07719.17 EMD68484.1 - 1.4e-18 65.5 5.0 0.00062 19.7 0.0 8.3 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_1 PF00515.28 EMD68484.1 - 9.8e-17 60.0 4.6 1.9e-06 27.4 0.0 6.4 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_14 PF13428.6 EMD68484.1 - 1.6e-10 40.9 3.6 0.95 10.5 0.0 7.1 3 2 4 7 7 7 2 Tetratricopeptide repeat TPR_9 PF13371.6 EMD68484.1 - 4.7e-10 39.5 4.2 0.0035 17.4 0.0 5.1 2 1 3 5 5 5 2 Tetratricopeptide repeat TPR_8 PF13181.6 EMD68484.1 - 1.4e-08 34.3 10.0 0.0032 17.6 0.0 6.4 8 0 0 8 8 6 3 Tetratricopeptide repeat TPR_17 PF13431.6 EMD68484.1 - 1.5e-06 28.1 1.3 0.0031 17.8 0.0 4.7 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 EMD68484.1 - 6.7e-06 26.5 9.3 0.17 12.4 0.0 5.6 4 3 3 7 7 7 2 Tetratricopeptide repeat TPR_6 PF13174.6 EMD68484.1 - 4.5e-05 23.8 11.6 3.6 8.4 0.0 6.6 7 1 0 7 7 5 2 Tetratricopeptide repeat TPR_16 PF13432.6 EMD68484.1 - 0.00015 22.3 3.7 0.057 14.1 0.0 4.4 2 1 3 5 5 5 1 Tetratricopeptide repeat TPR_12 PF13424.6 EMD68484.1 - 0.0017 18.6 11.4 0.06 13.6 0.0 5.8 5 3 2 7 7 7 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EMD68484.1 - 0.0072 16.5 8.3 0.8 10.0 0.1 5.4 4 1 2 6 6 6 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 EMD68484.1 - 0.0089 16.0 1.2 16 5.8 0.0 4.7 5 0 0 5 5 3 0 Tetratricopeptide repeat TPR_11 PF13414.6 EMD68484.1 - 0.075 12.7 6.2 0.22 11.2 0.0 4.5 6 0 0 6 6 6 0 TPR repeat DUF4893 PF16233.5 EMD68484.1 - 0.22 11.1 3.2 0.21 11.2 1.5 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4893) DUF3128 PF11326.8 EMD68484.1 - 2.4 8.6 4.4 6.7 7.1 0.3 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF3128) Glyco_hydro_5_C PF18564.1 EMD68485.1 - 8.7e-22 77.5 0.0 3.7e-21 75.4 0.0 2.1 2 0 0 2 2 2 1 Glycoside hydrolase family 5 C-terminal domain Cellulase PF00150.18 EMD68485.1 - 2.8e-12 46.7 5.9 3.3e-09 36.6 2.6 2.8 2 1 0 2 2 2 2 Cellulase (glycosyl hydrolase family 5) Xpo1 PF08389.12 EMD68486.1 - 2.3e-11 43.9 1.5 2.3e-07 31.0 0.0 3.6 3 0 0 3 3 3 2 Exportin 1-like protein IBN_N PF03810.19 EMD68486.1 - 8.1e-07 28.9 0.2 6.4e-05 22.8 0.0 3.3 3 0 0 3 3 3 1 Importin-beta N-terminal domain IFRD PF05004.13 EMD68486.1 - 0.00013 21.2 3.0 0.00074 18.7 0.1 3.2 3 0 0 3 3 3 1 Interferon-related developmental regulator (IFRD) MOR2-PAG1_N PF14222.6 EMD68486.1 - 0.0013 17.8 0.3 0.0038 16.2 0.0 1.9 2 0 0 2 2 2 1 Cell morphogenesis N-terminal HEAT_2 PF13646.6 EMD68486.1 - 0.02 15.3 1.4 3.3 8.2 0.0 3.8 3 1 0 3 3 3 0 HEAT repeats zf-CCCH_6 PF18585.1 EMD68486.1 - 0.19 11.7 1.1 2.6 8.0 0.3 3.0 2 0 0 2 2 2 0 Chromatin remodeling factor Mit1 C-terminal Zn finger 2 DUF5327 PF17261.2 EMD68486.1 - 0.85 10.4 0.0 0.85 10.4 0.0 2.6 3 0 0 3 3 3 0 Family of unknown function (DUF5327) DHDPS PF00701.22 EMD68487.1 - 9.6e-36 123.0 0.0 1.2e-35 122.6 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family Rsa3 PF14615.6 EMD68488.1 - 4.1e-22 77.5 0.1 4.6e-22 77.3 0.1 1.0 1 0 0 1 1 1 1 Ribosome-assembly protein 3 TPR_16 PF13432.6 EMD68489.1 - 6.3e-09 36.3 6.9 6.3e-09 36.3 2.3 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 EMD68489.1 - 2.1e-08 34.3 5.5 0.018 15.8 0.2 4.7 3 2 3 6 6 5 2 Tetratricopeptide repeat TPR_8 PF13181.6 EMD68489.1 - 1.5e-06 28.0 4.4 0.0022 18.1 0.3 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 EMD68489.1 - 1.2e-05 25.7 6.2 0.65 10.5 0.2 3.5 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 EMD68489.1 - 1.6e-05 24.6 6.5 0.41 10.9 0.7 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_22 PF18833.1 EMD68489.1 - 2.2e-05 24.5 0.0 6e-05 23.1 0.0 1.8 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_11 PF13414.6 EMD68489.1 - 0.00027 20.5 6.7 0.00045 19.8 0.2 2.8 3 0 0 3 3 3 1 TPR repeat TPR_12 PF13424.6 EMD68489.1 - 0.0012 19.1 1.1 0.33 11.3 0.2 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 EMD68489.1 - 0.0013 18.4 5.0 0.0032 17.2 0.8 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 EMD68489.1 - 0.0049 17.4 1.2 0.68 10.7 0.0 3.8 3 1 0 3 3 3 1 Tetratricopeptide repeat Prok-E2_C PF14459.6 EMD68489.1 - 0.069 13.3 0.0 0.14 12.3 0.0 1.4 1 0 0 1 1 1 0 Prokaryotic E2 family C TPR_21 PF09976.9 EMD68489.1 - 0.088 12.5 6.3 0.2 11.3 3.6 2.8 2 1 1 3 3 3 0 Tetratricopeptide repeat-like domain DUF4363 PF14276.6 EMD68489.1 - 0.17 12.0 1.0 0.42 10.8 0.4 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4363) TPR_1 PF00515.28 EMD68490.1 - 1.3e-35 119.7 19.6 0.00019 21.1 0.0 13.3 12 0 0 12 12 12 10 Tetratricopeptide repeat TPR_2 PF07719.17 EMD68490.1 - 1.4e-28 96.6 39.0 0.0025 17.8 0.0 14.5 15 0 0 15 15 14 9 Tetratricopeptide repeat TPR_8 PF13181.6 EMD68490.1 - 4e-26 89.0 23.4 0.031 14.5 0.0 13.2 14 0 0 14 14 14 6 Tetratricopeptide repeat TPR_17 PF13431.6 EMD68490.1 - 2.3e-25 87.1 6.2 0.003 17.8 0.5 11.7 12 0 0 12 12 10 4 Tetratricopeptide repeat TPR_14 PF13428.6 EMD68490.1 - 3.2e-22 77.3 18.3 0.038 14.8 0.1 12.7 11 4 2 13 13 11 5 Tetratricopeptide repeat TPR_12 PF13424.6 EMD68490.1 - 5.5e-20 71.4 31.1 0.0029 17.8 0.4 11.7 8 4 4 12 12 12 8 Tetratricopeptide repeat TPR_19 PF14559.6 EMD68490.1 - 8.6e-19 67.8 20.9 0.00084 19.8 2.0 11.3 9 3 3 12 12 12 5 Tetratricopeptide repeat TPR_11 PF13414.6 EMD68490.1 - 2.6e-18 65.4 16.5 0.0012 18.5 0.0 10.3 10 0 0 10 10 10 5 TPR repeat TPR_16 PF13432.6 EMD68490.1 - 6.9e-13 49.0 27.8 0.015 15.9 0.1 11.3 11 1 2 13 13 12 3 Tetratricopeptide repeat TPR_7 PF13176.6 EMD68490.1 - 3.5e-10 39.2 16.2 5.8 7.2 0.0 11.7 12 0 0 12 12 12 1 Tetratricopeptide repeat TPR_9 PF13371.6 EMD68490.1 - 4.4e-10 39.6 8.6 0.35 11.0 0.0 8.5 7 1 3 10 10 10 2 Tetratricopeptide repeat TPR_6 PF13174.6 EMD68490.1 - 1.2e-06 28.8 28.0 5.2 7.9 0.0 12.8 13 0 0 13 13 13 1 Tetratricopeptide repeat HemY_N PF07219.13 EMD68490.1 - 0.0053 16.9 2.8 25 5.1 0.0 4.7 3 1 1 4 4 4 0 HemY protein N-terminus ChAPs PF09295.10 EMD68490.1 - 0.017 14.2 1.2 15 4.5 0.0 4.7 4 1 1 5 5 5 0 ChAPs (Chs5p-Arf1p-binding proteins) TOM20_plant PF06552.12 EMD68490.1 - 0.02 14.6 4.5 23 4.7 0.1 4.3 5 0 0 5 5 3 0 Plant specific mitochondrial import receptor subunit TOM20 ANAPC5 PF12862.7 EMD68490.1 - 0.022 14.8 6.8 2.3 8.4 0.1 4.7 5 0 0 5 5 3 0 Anaphase-promoting complex subunit 5 TPR_20 PF14561.6 EMD68490.1 - 0.066 13.6 14.9 19 5.7 0.2 6.8 5 1 2 7 7 7 0 Tetratricopeptide repeat DUF4192 PF13830.6 EMD68490.1 - 0.23 11.5 3.8 0.44 10.5 0.1 3.1 3 1 0 3 3 3 0 Domain of unknown function (DUF4192) Fis1_TPR_C PF14853.6 EMD68490.1 - 0.64 10.1 3.0 6.6 6.9 0.0 4.2 5 0 0 5 5 5 0 Fis1 C-terminal tetratricopeptide repeat TPR_10 PF13374.6 EMD68490.1 - 0.85 9.6 21.4 4.7 7.2 0.0 8.3 9 0 0 9 9 9 0 Tetratricopeptide repeat Trypan_PARP PF05887.11 EMD68492.1 - 0.13 12.2 0.4 0.26 11.3 0.4 1.4 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Glyco_hydro_17 PF00332.18 EMD68494.1 - 0.00018 21.2 0.1 0.00029 20.5 0.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 17 XPG_N PF00752.17 EMD68495.1 - 2.1e-23 82.7 0.0 4e-23 81.8 0.0 1.5 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 EMD68495.1 - 1.8e-22 79.5 0.3 4.3e-22 78.3 0.0 1.8 2 0 0 2 2 2 1 XPG I-region XPG_I_2 PF12813.7 EMD68495.1 - 2.9e-06 27.0 0.0 4.5e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 XPG domain containing 5_3_exonuc PF01367.20 EMD68495.1 - 0.00077 20.0 0.0 0.0019 18.7 0.0 1.6 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold HHH_5 PF14520.6 EMD68495.1 - 0.043 14.4 0.3 16 6.2 0.2 2.6 2 0 0 2 2 2 0 Helix-hairpin-helix domain REV PF00424.18 EMD68495.1 - 0.057 13.4 0.7 6 7.0 0.0 3.6 3 0 0 3 3 3 0 REV protein (anti-repression trans-activator protein) DUF5073 PF16817.5 EMD68495.1 - 0.16 12.0 0.0 0.32 11.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5073) Tma16 PF11176.8 EMD68496.1 - 7.3e-49 165.4 2.5 1e-48 164.9 2.5 1.2 1 0 0 1 1 1 1 Translation machinery-associated protein 16 DUF3616 PF12275.8 EMD68496.1 - 0.0051 16.3 0.2 0.0069 15.8 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3616) AbiGi PF10899.8 EMD68496.1 - 0.018 14.9 0.2 0.026 14.4 0.2 1.2 1 0 0 1 1 1 0 Putative abortive phage resistance protein AbiGi, antitoxin XH PF03469.14 EMD68496.1 - 0.049 13.5 0.3 0.096 12.6 0.2 1.7 1 1 0 1 1 1 0 XH domain DUF1330 PF07045.11 EMD68497.1 - 4.8e-05 23.6 0.0 0.041 14.2 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF1330) ABM PF03992.16 EMD68497.1 - 0.00012 22.1 0.0 0.0089 16.1 0.0 2.3 2 0 0 2 2 2 1 Antibiotic biosynthesis monooxygenase Glyco_hydr_116N PF12215.8 EMD68497.1 - 0.14 11.6 0.0 0.15 11.5 0.0 1.2 1 0 0 1 1 1 0 beta-glucosidase 2, glycosyl-hydrolase family 116 N-term Gly_transf_sug PF04488.15 EMD68498.1 - 6.5e-09 36.3 0.0 1.6e-08 35.1 0.0 1.7 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif TcdA_TcdB PF12919.7 EMD68498.1 - 0.0042 16.4 0.0 0.078 12.3 0.0 2.1 2 0 0 2 2 2 1 TcdA/TcdB catalytic glycosyltransferase domain Caps_synth PF05704.12 EMD68498.1 - 0.093 12.1 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 Capsular polysaccharide synthesis protein ANAPC4_WD40 PF12894.7 EMD68499.1 - 0.0076 16.5 0.0 7.4 7.0 0.1 3.9 1 1 3 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EMD68499.1 - 0.088 13.7 0.5 2.4 9.2 0.3 2.7 2 0 0 2 2 2 0 WD domain, G-beta repeat DGF-1_C PF11040.8 EMD68499.1 - 0.25 11.4 2.2 1 9.4 2.2 2.1 1 0 0 1 1 1 0 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus CorA PF01544.18 EMD68499.1 - 0.27 10.5 1.2 0.51 9.6 1.2 1.4 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Proteasome PF00227.26 EMD68500.1 - 2e-45 154.6 0.1 2.8e-45 154.2 0.1 1.2 1 0 0 1 1 1 1 Proteasome subunit Pr_beta_C PF12465.8 EMD68500.1 - 7.3e-14 50.9 1.2 7.3e-14 50.9 1.2 2.0 3 0 0 3 3 3 1 Proteasome beta subunits C terminal Actin PF00022.19 EMD68501.1 - 2.7e-136 454.4 0.0 3.1e-136 454.2 0.0 1.0 1 0 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EMD68501.1 - 0.21 10.4 0.0 15 4.3 0.0 2.4 3 0 0 3 3 3 0 MreB/Mbl protein MBOAT PF03062.19 EMD68502.1 - 2.2e-47 162.1 11.5 3.6e-47 161.4 11.5 1.3 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family Glyco_hydro_17 PF00332.18 EMD68503.1 - 2.5e-06 27.3 0.1 4.5e-06 26.5 0.1 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 17 Pyridoxal_deC PF00282.19 EMD68504.1 - 5.4e-78 262.3 0.0 9.2e-78 261.6 0.0 1.3 2 0 0 2 2 2 1 Pyridoxal-dependent decarboxylase conserved domain Beta_elim_lyase PF01212.21 EMD68504.1 - 1.7e-07 30.9 0.0 2.2e-07 30.5 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.19 EMD68504.1 - 0.0012 17.9 0.0 0.0022 17.0 0.0 1.5 1 1 0 1 1 1 1 Aminotransferase class-V PUF PF00806.19 EMD68505.1 - 1.8e-11 43.0 0.0 0.43 10.4 0.0 7.0 7 0 0 7 7 7 4 Pumilio-family RNA binding repeat MIF4G PF02854.19 EMD68505.1 - 0.06 13.0 0.0 1.9 8.1 0.0 2.3 2 0 0 2 2 2 0 MIF4G domain RINT1_TIP1 PF04437.13 EMD68506.1 - 6.2e-173 576.2 0.0 1.9e-172 574.7 0.0 1.7 2 0 0 2 2 2 1 RINT-1 / TIP-1 family CRISPR_Cse2 PF09485.10 EMD68506.1 - 0.029 14.9 4.9 0.025 15.1 2.4 2.1 2 1 0 2 2 2 0 CRISPR-associated protein Cse2 (CRISPR_cse2) Baculo_PEP_C PF04513.12 EMD68506.1 - 0.032 14.3 6.6 13 5.8 0.0 4.4 4 1 0 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Prominin PF05478.11 EMD68506.1 - 0.18 9.7 1.3 1.5 6.7 0.5 2.0 2 0 0 2 2 2 0 Prominin TBCC_N PF16752.5 EMD68506.1 - 1.3 9.5 3.9 5.8 7.4 3.4 2.4 1 1 1 2 2 2 0 Tubulin-specific chaperone C N-terminal domain MT0933_antitox PF14013.6 EMD68507.1 - 0.016 15.5 5.3 0.33 11.3 1.0 2.3 1 1 1 2 2 2 0 MT0933-like antitoxin protein MT0933_antitox PF14013.6 EMD68508.1 - 8.3e-06 26.0 2.8 0.0089 16.3 0.3 2.1 1 1 1 2 2 2 2 MT0933-like antitoxin protein Folliculin PF11704.8 EMD68509.1 - 1.6e-55 187.9 0.0 3.6e-55 186.7 0.0 1.6 1 1 0 1 1 1 1 Vesicle coat protein involved in Golgi to plasma membrane transport ATG16 PF08614.11 EMD68509.1 - 0.3 11.3 0.2 0.67 10.2 0.1 1.6 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) F-box PF00646.33 EMD68510.1 - 0.055 13.4 0.2 0.055 13.4 0.2 2.1 2 0 0 2 2 2 0 F-box domain COesterase PF00135.28 EMD68511.1 - 7e-75 252.8 0.0 9.1e-75 252.5 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EMD68511.1 - 4.4e-07 30.0 0.1 9.5e-05 22.3 0.0 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold LEA_4 PF02987.16 EMD68512.1 - 0.0017 18.4 20.3 0.015 15.4 8.7 2.4 2 1 1 3 3 3 2 Late embryogenesis abundant protein DUF883 PF05957.13 EMD68512.1 - 0.086 13.5 2.9 0.15 12.7 2.3 1.7 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) YtxH PF12732.7 EMD68512.1 - 0.12 12.9 8.8 0.067 13.7 4.6 2.0 1 1 1 2 2 2 0 YtxH-like protein ISG65-75 PF11727.8 EMD68512.1 - 0.46 9.7 9.7 0.57 9.4 9.7 1.1 1 0 0 1 1 1 0 Invariant surface glycoprotein DivIVA PF05103.13 EMD68512.1 - 0.79 9.8 5.0 1.3 9.1 4.5 1.7 1 1 1 2 2 2 0 DivIVA protein CsbD PF05532.12 EMD68512.1 - 0.84 9.6 18.7 0.22 11.5 5.8 2.9 2 1 1 3 3 3 0 CsbD-like Acetyltransf_13 PF13880.6 EMD68519.1 - 8.4e-27 92.9 0.0 1.9e-26 91.8 0.0 1.6 1 0 0 1 1 1 1 ESCO1/2 acetyl-transferase zf-C2H2_3 PF13878.6 EMD68519.1 - 9.7e-14 50.9 0.4 2.3e-13 49.7 0.4 1.7 1 0 0 1 1 1 1 zinc-finger of acetyl-transferase ESCO Acetyltransf_7 PF13508.7 EMD68519.1 - 0.016 15.7 0.0 0.031 14.7 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 EMD68520.1 - 1.1e-23 84.4 0.0 1.4e-23 84.1 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EMD68520.1 - 1.2e-05 25.6 0.0 1.6e-05 25.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_4 PF13420.7 EMD68520.1 - 0.001 19.2 0.0 0.0013 18.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 EMD68520.1 - 0.0046 16.6 0.0 0.0068 16.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain TSP_NTD PF17804.1 EMD68521.1 - 0.029 14.6 0.0 0.046 14.0 0.0 1.3 1 0 0 1 1 1 0 Tail specific protease N-terminal domain CLP_protease PF00574.23 EMD68522.1 - 1.4e-77 259.7 0.0 1.7e-77 259.4 0.0 1.1 1 0 0 1 1 1 1 Clp protease Clr5 PF14420.6 EMD68522.1 - 0.0056 16.9 1.0 0.02 15.1 0.3 2.0 2 0 0 2 2 2 1 Clr5 domain Peptidase_S49 PF01343.18 EMD68522.1 - 0.19 11.7 0.0 0.39 10.7 0.0 1.5 1 0 0 1 1 1 0 Peptidase family S49 RdRP PF05183.12 EMD68523.1 - 3.1e-178 594.1 0.0 4.1e-178 593.7 0.0 1.2 1 0 0 1 1 1 1 RNA dependent RNA polymerase Ank_4 PF13637.6 EMD68524.1 - 1.2e-10 41.6 0.0 6.2e-07 29.9 0.0 2.0 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EMD68524.1 - 9.4e-07 29.3 0.0 9.5e-06 26.1 0.0 1.9 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 EMD68524.1 - 4.1e-06 27.0 0.0 0.095 13.2 0.0 2.2 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.6 EMD68524.1 - 5.3e-05 23.4 0.0 0.016 15.5 0.0 2.1 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMD68524.1 - 0.00019 21.6 0.0 0.89 10.3 0.0 2.2 2 0 0 2 2 2 2 Ankyrin repeat Cellulase PF00150.18 EMD68528.1 - 5.1e-24 85.2 0.2 7e-24 84.7 0.2 1.1 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Peptidase_MA_2 PF13485.6 EMD68531.1 - 0.053 13.2 0.0 0.09 12.4 0.0 1.4 1 0 0 1 1 1 0 Peptidase MA superfamily SelB-wing_3 PF09107.11 EMD68531.1 - 0.13 11.9 0.2 0.28 10.8 0.2 1.6 1 0 0 1 1 1 0 Elongation factor SelB, winged helix CUE PF02845.16 EMD68532.1 - 8.9e-11 41.3 0.1 2.4e-10 39.9 0.1 1.8 2 0 0 2 2 2 1 CUE domain Ribosomal_S10 PF00338.22 EMD68533.1 - 2.9e-28 98.0 0.6 3.4e-28 97.8 0.6 1.0 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e COG5 PF10392.9 EMD68534.1 - 0.023 14.9 0.1 0.048 13.8 0.1 1.5 1 0 0 1 1 1 0 Golgi transport complex subunit 5 D-ser_dehydrat PF14031.6 EMD68536.1 - 1e-22 80.6 0.0 2.7e-22 79.2 0.0 1.8 1 0 0 1 1 1 1 Putative serine dehydratase domain Ala_racemase_N PF01168.20 EMD68536.1 - 3.2e-14 53.1 0.0 4.6e-14 52.6 0.0 1.2 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain PKD_channel PF08016.12 EMD68537.1 - 0.0043 15.8 2.8 0.59 8.7 0.7 2.4 2 0 0 2 2 2 2 Polycystin cation channel DnaJ PF00226.31 EMD68538.1 - 5.1e-10 39.3 0.0 1.3e-09 38.0 0.0 1.7 2 0 0 2 2 2 1 DnaJ domain Siva PF05458.12 EMD68538.1 - 0.0067 16.1 5.4 0.009 15.7 5.4 1.2 1 0 0 1 1 1 1 Cd27 binding protein (Siva) MFS_5 PF05631.14 EMD68539.1 - 1.7e-61 208.1 3.2 2.7e-61 207.4 3.2 1.2 1 0 0 1 1 1 1 Sugar-tranasporters, 12 TM MFS_1 PF07690.16 EMD68539.1 - 9.3e-26 90.6 20.6 1.4e-25 90.0 20.6 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Methyltransf_22 PF13383.6 EMD68540.1 - 1.5e-13 50.9 0.0 2.1e-13 50.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_21 PF05050.12 EMD68540.1 - 4e-08 33.5 0.0 5.3e-08 33.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase FkbM domain 2_5_RNA_ligase2 PF13563.6 EMD68541.1 - 2e-27 95.9 0.3 1.1e-26 93.6 0.1 2.3 3 0 0 3 3 3 1 2'-5' RNA ligase superfamily PAP_central PF04928.17 EMD68541.1 - 2.7e-19 69.1 0.0 6.2e-19 68.0 0.0 1.6 1 0 0 1 1 1 1 Poly(A) polymerase central domain MJ1316 PF04457.12 EMD68541.1 - 1.2e-18 67.6 0.1 4.8e-18 65.7 0.0 2.2 2 0 0 2 2 2 1 MJ1316 RNA cyclic group end recognition domain Exo_endo_phos PF03372.23 EMD68541.1 - 1.4e-08 34.5 0.0 2.9e-08 33.5 0.0 1.6 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family NTP_transf_2 PF01909.23 EMD68541.1 - 4.8e-05 23.6 0.1 0.00019 21.6 0.0 2.0 2 0 0 2 2 2 1 Nucleotidyltransferase domain Nrap_D2 PF17403.2 EMD68541.1 - 0.00084 19.1 0.5 0.003 17.4 0.0 2.1 2 0 0 2 2 2 1 Nrap protein PAP/OAS-like domain TPR_6 PF13174.6 EMD68541.1 - 0.038 14.6 0.3 0.69 10.7 0.0 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat PAP_assoc PF03828.19 EMD68541.1 - 0.061 13.5 0.1 0.16 12.2 0.1 1.7 1 0 0 1 1 1 0 Cid1 family poly A polymerase Transferase PF02458.15 EMD68542.1 - 0.00073 18.3 0.0 0.17 10.5 0.0 2.3 2 1 0 2 2 2 2 Transferase family WW_FCH_linker PF16623.5 EMD68543.1 - 0.04 14.7 0.3 0.15 12.8 0.3 1.9 1 0 0 1 1 1 0 Unstructured linker region between on GAS7 protein DUF898 PF05987.13 EMD68543.1 - 0.052 12.6 2.0 0.073 12.1 2.0 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF898) DUF5336 PF17270.2 EMD68543.1 - 0.096 12.3 0.3 0.14 11.8 0.3 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5336) PDCD2_C PF04194.13 EMD68543.1 - 0.12 12.5 0.5 0.23 11.5 0.5 1.4 1 0 0 1 1 1 0 Programmed cell death protein 2, C-terminal putative domain DUF1282 PF06930.12 EMD68543.1 - 0.14 11.9 3.0 0.18 11.5 3.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1282) Peptidase_C14 PF00656.22 EMD68545.1 - 0.0014 18.6 0.1 0.046 13.7 0.0 2.5 2 1 0 3 3 3 1 Caspase domain MFS_1 PF07690.16 EMD68546.1 - 6.8e-43 146.9 40.6 6.8e-43 146.9 40.6 1.6 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EMD68546.1 - 3e-12 46.2 13.2 3e-12 46.2 13.2 2.9 2 1 0 3 3 3 1 Sugar (and other) transporter MFS_4 PF06779.14 EMD68546.1 - 3.7e-08 33.0 9.5 3.7e-08 33.0 9.5 2.5 2 1 1 3 3 3 1 Uncharacterised MFS-type transporter YbfB PNP_UDP_1 PF01048.20 EMD68547.1 - 2.3e-12 46.7 1.4 5.4e-12 45.5 1.4 1.6 1 1 0 1 1 1 1 Phosphorylase superfamily Peptidase_S28 PF05577.12 EMD68548.1 - 5.3e-22 78.2 0.0 7.6e-16 57.9 0.0 2.2 2 0 0 2 2 2 2 Serine carboxypeptidase S28 SPEG_u2 PF16650.5 EMD68548.1 - 0.095 12.9 0.2 0.24 11.6 0.2 1.7 1 0 0 1 1 1 0 Unstructured region on SPEG complex protein PNP_UDP_1 PF01048.20 EMD68549.1 - 1.4e-05 24.5 2.8 0.00029 20.2 2.8 2.2 1 1 0 1 1 1 1 Phosphorylase superfamily WD40 PF00400.32 EMD68550.1 - 6.7e-39 131.2 20.1 5.2e-09 36.6 0.4 7.2 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD68550.1 - 2.2e-12 47.1 5.9 0.032 14.5 0.0 5.8 1 1 4 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EMD68550.1 - 1.2e-07 31.0 9.9 0.023 13.7 0.4 4.1 1 1 2 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein AAA_16 PF13191.6 EMD68550.1 - 5e-07 30.3 0.1 1.1e-06 29.1 0.1 1.5 1 0 0 1 1 1 1 AAA ATPase domain NACHT PF05729.12 EMD68550.1 - 1.6e-06 28.1 0.0 3.2e-06 27.1 0.0 1.5 1 0 0 1 1 1 1 NACHT domain Nup160 PF11715.8 EMD68550.1 - 0.00044 19.0 17.1 0.29 9.7 0.1 5.8 1 1 2 5 5 5 2 Nucleoporin Nup120/160 Asp_decarbox PF02261.16 EMD68550.1 - 0.0027 17.6 0.0 53 3.8 0.0 4.4 2 2 2 4 4 4 0 Aspartate decarboxylase APS_kinase PF01583.20 EMD68550.1 - 0.0089 15.9 0.0 0.016 15.1 0.0 1.4 1 0 0 1 1 1 1 Adenylylsulphate kinase CDtoxinA PF03498.14 EMD68550.1 - 0.05 13.2 2.7 1.7 8.2 0.6 3.6 1 1 2 4 4 4 0 Cytolethal distending toxin A/C domain AAA_18 PF13238.6 EMD68550.1 - 0.061 13.9 0.0 0.14 12.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EMD68550.1 - 0.066 13.5 0.0 0.28 11.5 0.0 2.0 2 0 0 2 2 2 0 AAA domain Utp8 PF10395.9 EMD68550.1 - 0.098 11.1 0.1 0.15 10.5 0.1 1.2 1 0 0 1 1 1 0 Utp8 family AAA PF00004.29 EMD68550.1 - 0.11 12.9 0.0 0.24 11.8 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 EMD68550.1 - 0.21 11.3 0.0 0.43 10.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain Epimerase PF01370.21 EMD68551.1 - 7e-19 68.2 0.0 1.4e-18 67.3 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EMD68551.1 - 2.4e-11 43.6 0.0 2.6e-09 36.9 0.0 2.1 2 0 0 2 2 2 2 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 EMD68551.1 - 5.3e-11 42.0 0.0 7.4e-10 38.3 0.0 2.0 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 EMD68551.1 - 2.6e-09 37.2 0.1 1.5e-08 34.7 0.1 2.2 1 1 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EMD68551.1 - 1.8e-07 31.0 0.0 2.6e-07 30.4 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family NAD_binding_4 PF07993.12 EMD68551.1 - 2.3e-05 23.7 0.0 0.0075 15.5 0.0 2.3 2 0 0 2 2 2 2 Male sterility protein adh_short PF00106.25 EMD68551.1 - 6.6e-05 22.5 0.0 0.22 11.0 0.0 2.2 2 0 0 2 2 2 2 short chain dehydrogenase Polysacc_synt_2 PF02719.15 EMD68551.1 - 0.00031 20.0 0.0 0.00048 19.4 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein KR PF08659.10 EMD68551.1 - 0.042 13.8 0.0 0.089 12.7 0.0 1.6 1 0 0 1 1 1 0 KR domain NmrA PF05368.13 EMD68552.1 - 1.5e-31 109.8 0.0 1.6e-31 109.7 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EMD68552.1 - 2.3e-08 34.2 0.0 3.3e-08 33.6 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EMD68552.1 - 0.0017 17.9 0.0 0.004 16.6 0.0 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Sacchrp_dh_NADP PF03435.18 EMD68552.1 - 0.18 12.1 0.0 0.27 11.5 0.0 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain AltA1 PF16541.5 EMD68553.1 - 2e-05 25.4 0.0 2.6e-05 25.0 0.0 1.1 1 0 0 1 1 1 1 Alternaria alternata allergen 1 Ank_2 PF12796.7 EMD68554.1 - 1.2e-16 61.0 0.1 1.2e-11 45.0 0.0 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EMD68554.1 - 2.7e-13 48.8 0.2 6.6e-05 23.0 0.0 3.7 4 0 0 4 4 4 3 Ankyrin repeat Ank_4 PF13637.6 EMD68554.1 - 9e-11 42.1 0.0 8.9e-06 26.2 0.0 2.9 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 EMD68554.1 - 2.3e-10 40.4 0.0 0.0057 17.1 0.0 3.4 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.6 EMD68554.1 - 6.5e-08 32.7 0.1 0.0082 16.4 0.0 3.3 1 1 1 3 3 3 3 Ankyrin repeats (many copies) DUF1987 PF09345.10 EMD68555.1 - 0.022 14.4 0.5 0.044 13.4 0.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1987) HET PF06985.11 EMD68557.1 - 1e-24 87.6 0.0 1.3e-24 87.2 0.0 1.1 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) p450 PF00067.22 EMD68558.1 - 3.2e-10 39.4 0.0 3.3e-10 39.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 HET PF06985.11 EMD68559.1 - 1.9e-35 122.4 3.7 2.9e-35 121.7 3.7 1.3 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) TIR_2 PF13676.6 EMD68559.1 - 0.033 14.8 0.4 0.12 13.0 0.1 2.1 1 1 1 2 2 2 0 TIR domain Yip1 PF04893.17 EMD68560.1 - 0.0038 17.0 3.2 0.0057 16.4 3.2 1.2 1 0 0 1 1 1 1 Yip1 domain Amastin PF07344.11 EMD68560.1 - 0.0065 16.3 3.6 0.0065 16.3 3.6 1.4 2 0 0 2 2 2 1 Amastin surface glycoprotein Anoctamin PF04547.12 EMD68560.1 - 0.016 14.1 0.1 0.018 13.9 0.1 1.1 1 0 0 1 1 1 0 Calcium-activated chloride channel DSBA PF01323.20 EMD68561.1 - 3.6e-11 43.2 0.0 4e-11 43.1 0.0 1.0 1 0 0 1 1 1 1 DSBA-like thioredoxin domain GST_N PF02798.20 EMD68562.1 - 7.2e-15 55.1 0.0 2e-14 53.6 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EMD68562.1 - 2.7e-13 49.9 0.0 4e-13 49.4 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EMD68562.1 - 5e-10 39.6 0.0 1e-09 38.7 0.0 1.5 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EMD68562.1 - 1.2e-09 38.0 0.0 2.6e-09 37.0 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 EMD68562.1 - 5.6e-08 33.0 0.0 8.8e-08 32.3 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EMD68562.1 - 2.8e-06 27.5 0.0 4.2e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 EMD68562.1 - 0.068 13.9 0.0 0.11 13.3 0.0 1.3 1 0 0 1 1 1 0 Glutathione S-transferase N-terminal domain Fungal_trans PF04082.18 EMD68563.1 - 2e-12 46.7 0.0 3.7e-12 45.8 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain HTH_Tnp_Tc5 PF03221.16 EMD68564.1 - 0.012 15.6 0.0 0.014 15.4 0.0 1.1 1 0 0 1 1 1 0 Tc5 transposase DNA-binding domain Cu_amine_oxid PF01179.20 EMD68565.1 - 4.2e-158 526.6 0.0 6e-158 526.1 0.0 1.2 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN3 PF02728.16 EMD68565.1 - 2.5e-19 69.5 0.3 8.7e-19 67.8 0.1 2.0 2 0 0 2 2 2 1 Copper amine oxidase, N3 domain Cu_amine_oxidN2 PF02727.16 EMD68565.1 - 1.2e-11 44.7 0.0 2e-11 44.0 0.0 1.4 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain Aldedh PF00171.22 EMD68566.1 - 2.2e-153 511.1 0.0 2.5e-153 510.9 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Cupin_2 PF07883.11 EMD68567.1 - 1.6e-05 24.5 0.4 2.2e-05 24.0 0.4 1.2 1 0 0 1 1 1 1 Cupin domain Cupin_3 PF05899.12 EMD68567.1 - 0.00011 21.8 0.3 0.00016 21.3 0.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF861) Pirin PF02678.16 EMD68567.1 - 0.035 14.1 0.1 0.08 12.9 0.1 1.6 1 1 0 1 1 1 0 Pirin EutQ PF06249.12 EMD68567.1 - 0.069 12.9 0.0 0.096 12.4 0.0 1.1 1 0 0 1 1 1 0 Ethanolamine utilisation protein EutQ AraC_binding PF02311.19 EMD68567.1 - 0.1 12.5 0.0 0.14 12.0 0.0 1.2 1 0 0 1 1 1 0 AraC-like ligand binding domain S1 PF00575.23 EMD68567.1 - 0.16 12.3 0.3 0.36 11.2 0.0 1.6 2 0 0 2 2 2 0 S1 RNA binding domain Cupin_6 PF12852.7 EMD68567.1 - 0.24 11.1 0.0 0.27 11.0 0.0 1.1 1 0 0 1 1 1 0 Cupin Amino_oxidase PF01593.24 EMD68568.1 - 7e-49 167.3 0.0 8.8e-49 167.0 0.0 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EMD68568.1 - 8e-11 42.0 0.1 1.8e-10 40.9 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 EMD68568.1 - 5.4e-08 32.4 0.0 1.1e-07 31.4 0.0 1.4 1 0 0 1 1 1 1 Thi4 family Lycopene_cycl PF05834.12 EMD68568.1 - 2.5e-06 26.8 0.3 6.4e-05 22.2 0.0 2.1 2 0 0 2 2 2 1 Lycopene cyclase protein DAO PF01266.24 EMD68568.1 - 5.4e-06 26.2 0.0 1.2e-05 25.1 0.0 1.6 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EMD68568.1 - 4.6e-05 22.8 0.1 0.0001 21.7 0.0 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EMD68568.1 - 7.3e-05 22.0 0.0 0.00012 21.3 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 EMD68568.1 - 0.0002 20.8 0.1 0.00067 19.1 0.0 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase HI0933_like PF03486.14 EMD68568.1 - 0.0026 16.5 0.1 0.0051 15.6 0.0 1.5 2 0 0 2 2 2 1 HI0933-like protein NAD_binding_9 PF13454.6 EMD68568.1 - 0.0028 17.6 0.3 0.1 12.6 0.0 2.3 2 0 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox PF00070.27 EMD68568.1 - 0.055 14.0 0.6 0.1 13.2 0.1 1.7 2 0 0 2 2 1 0 Pyridine nucleotide-disulphide oxidoreductase AA_permease_2 PF13520.6 EMD68569.1 - 1.8e-44 152.2 46.7 2.5e-44 151.8 46.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EMD68569.1 - 1e-14 54.1 40.7 1.3e-14 53.7 40.7 1.0 1 0 0 1 1 1 1 Amino acid permease TPP_enzyme_N PF02776.18 EMD68570.1 - 6e-38 130.2 0.5 1.1e-37 129.3 0.1 1.6 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 EMD68570.1 - 4.1e-18 65.6 0.4 9.2e-18 64.5 0.0 1.8 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 EMD68570.1 - 3.7e-09 36.4 0.0 1.5e-08 34.5 0.0 2.0 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain NTP_transf_3 PF12804.7 EMD68570.1 - 0.14 12.5 0.9 1.1 9.6 0.1 2.8 2 1 0 2 2 2 0 MobA-like NTP transferase domain Fungal_trans_2 PF11951.8 EMD68571.1 - 1.4e-32 112.9 9.3 1.9e-32 112.6 7.5 2.0 2 1 0 2 2 2 1 Fungal specific transcription factor domain TetR_C_28 PF17937.1 EMD68571.1 - 0.15 12.5 0.2 0.15 12.5 0.2 2.0 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain FAD-oxidase_C PF02913.19 EMD68572.1 - 3.9e-65 220.0 0.3 5.9e-65 219.4 0.1 1.4 2 0 0 2 2 2 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 EMD68572.1 - 3.9e-33 114.1 0.0 9.1e-33 112.9 0.0 1.7 1 0 0 1 1 1 1 FAD binding domain LysM PF01476.20 EMD68574.1 - 6e-22 77.4 4.7 1.1e-05 25.3 0.0 6.3 6 0 0 6 6 6 6 LysM domain HTH_23 PF13384.6 EMD68574.1 - 0.21 11.5 0.1 5.5 6.9 0.0 2.9 3 0 0 3 3 3 0 Homeodomain-like domain Glyco_hydro_18 PF00704.28 EMD68575.1 - 9e-73 245.7 0.3 1.3e-72 245.2 0.3 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Chitin_bind_1 PF00187.19 EMD68575.1 - 8.8e-13 48.5 12.8 8.8e-13 48.5 12.8 4.5 3 1 0 3 3 3 2 Chitin recognition protein Pollen_allerg_1 PF01357.21 EMD68576.1 - 0.0001 22.3 0.4 0.00072 19.5 0.4 2.1 1 1 1 2 2 2 2 Pollen allergen DPBB_1 PF03330.18 EMD68576.1 - 0.0025 18.0 2.6 0.0065 16.7 0.1 2.6 2 1 0 2 2 2 1 Lytic transglycolase Cerato-platanin PF07249.12 EMD68576.1 - 0.053 13.6 0.9 0.11 12.6 0.8 1.7 1 1 0 1 1 1 0 Cerato-platanin UNC-50 PF05216.13 EMD68577.1 - 9.1e-83 277.2 15.7 1e-82 277.0 15.7 1.0 1 0 0 1 1 1 1 UNC-50 family Suf PF05843.14 EMD68578.1 - 1.7e-93 313.8 15.4 2.9e-90 303.2 0.0 5.2 4 1 1 5 5 5 2 Suppressor of forked protein (Suf) TPR_14 PF13428.6 EMD68578.1 - 0.0024 18.6 9.4 0.035 14.9 0.0 5.8 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_16 PF13432.6 EMD68578.1 - 0.0031 18.1 0.1 0.21 12.2 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 EMD68578.1 - 0.0049 17.3 0.0 0.044 14.3 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat HAT PF02184.16 EMD68578.1 - 0.11 12.5 11.6 0.1 12.6 1.0 3.5 3 0 0 3 3 3 0 HAT (Half-A-TPR) repeat ATP-synt_E PF05680.12 EMD68578.1 - 4.5 7.7 5.9 16 5.9 5.9 1.9 1 0 0 1 1 1 0 ATP synthase E chain Piwi PF02171.17 EMD68579.1 - 1.3e-75 254.5 0.0 1.8e-75 254.0 0.0 1.2 1 0 0 1 1 1 1 Piwi domain ArgoN PF16486.5 EMD68579.1 - 8.8e-18 65.2 0.0 2e-17 64.1 0.0 1.7 1 0 0 1 1 1 1 N-terminal domain of argonaute ArgoL1 PF08699.10 EMD68579.1 - 5.8e-17 61.1 0.3 1.8e-16 59.5 0.3 2.0 1 0 0 1 1 1 1 Argonaute linker 1 domain PAZ PF02170.22 EMD68579.1 - 1.1e-15 57.7 0.2 2e-15 56.8 0.2 1.4 1 0 0 1 1 1 1 PAZ domain ArgoL2 PF16488.5 EMD68579.1 - 8.6e-12 45.2 0.0 2.5e-11 43.7 0.0 1.9 1 0 0 1 1 1 1 Argonaute linker 2 domain ArgoMid PF16487.5 EMD68579.1 - 3.4e-06 27.2 0.0 1.3e-05 25.4 0.0 2.0 1 0 0 1 1 1 1 Mid domain of argonaute PP28 PF10252.9 EMD68580.1 - 5.5e-27 94.0 21.9 5.5e-27 94.0 21.9 3.2 2 1 1 3 3 3 2 Casein kinase substrate phosphoprotein PP28 HNH PF01844.23 EMD68581.1 - 0.0095 16.1 0.3 0.023 14.9 0.3 1.7 1 1 0 1 1 1 1 HNH endonuclease Dopey_N PF04118.14 EMD68583.1 - 7.8e-116 386.5 0.0 5.2e-115 383.8 0.0 2.4 3 0 0 3 3 3 1 Dopey, N-terminal DUF202 PF02656.15 EMD68584.1 - 0.097 13.1 0.0 0.11 12.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF202) DUF4663 PF15668.5 EMD68585.1 - 0.3 10.1 4.9 0.32 10.0 4.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4663) ER-remodelling PF14755.6 EMD68585.1 - 1.6 9.0 13.6 18 5.6 13.6 2.0 1 1 0 1 1 1 0 Intracellular membrane remodeller Phtf-FEM1B_bdg PF12129.8 EMD68586.1 - 3.7 7.3 5.0 5.4 6.8 5.0 1.3 1 0 0 1 1 1 0 Male germ-cell putative homeodomain transcription factor zf-C2H2_4 PF13894.6 EMD68587.1 - 6.3e-05 23.5 11.2 0.12 13.3 0.1 3.8 3 0 0 3 3 3 3 C2H2-type zinc finger FOXP-CC PF16159.5 EMD68587.1 - 0.00069 20.2 1.8 0.026 15.2 0.0 2.4 2 0 0 2 2 2 1 FOXP coiled-coil domain zf-C2H2 PF00096.26 EMD68587.1 - 0.0017 18.7 16.0 0.018 15.4 0.1 3.9 3 1 0 3 3 3 3 Zinc finger, C2H2 type DAO PF01266.24 EMD68589.1 - 2.1e-33 116.4 0.0 2.7e-33 116.0 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EMD68589.1 - 6.7e-07 28.7 0.3 1.6e-06 27.5 0.3 1.6 1 1 0 1 1 1 1 FAD binding domain ThiF PF00899.21 EMD68589.1 - 0.00028 20.3 0.0 0.00052 19.4 0.0 1.4 1 0 0 1 1 1 1 ThiF family Shikimate_DH PF01488.20 EMD68589.1 - 0.0011 19.0 0.0 0.029 14.4 0.0 2.4 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase GIDA PF01134.22 EMD68589.1 - 0.0014 17.8 0.1 0.89 8.6 0.0 2.2 2 0 0 2 2 2 2 Glucose inhibited division protein A Pyr_redox_2 PF07992.14 EMD68589.1 - 0.0022 17.3 0.0 0.02 14.1 0.0 2.3 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GMC_oxred_N PF00732.19 EMD68589.1 - 0.0026 17.2 0.0 1.3 8.3 0.0 2.2 2 0 0 2 2 2 2 GMC oxidoreductase NAD_binding_8 PF13450.6 EMD68589.1 - 0.0035 17.5 0.0 0.0098 16.1 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_Gly3P_dh_N PF01210.23 EMD68589.1 - 0.011 15.7 0.3 0.059 13.3 0.3 1.9 1 1 1 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus ApbA PF02558.16 EMD68589.1 - 0.014 15.1 0.0 0.027 14.1 0.0 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Pyr_redox PF00070.27 EMD68589.1 - 0.019 15.5 0.1 0.32 11.6 0.0 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.6 EMD68589.1 - 0.027 14.9 0.0 0.052 14.0 0.0 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding Lycopene_cycl PF05834.12 EMD68589.1 - 0.095 11.7 0.0 0.17 10.9 0.0 1.4 1 0 0 1 1 1 0 Lycopene cyclase protein NEXCaM_BD PF16644.5 EMD68589.1 - 0.11 12.7 0.0 0.23 11.7 0.0 1.4 1 0 0 1 1 1 0 Regulatory region of Na+/H+ exchanger NHE binds to calmodulin Pyr_redox_3 PF13738.6 EMD68589.1 - 0.2 10.9 0.0 0.36 10.0 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase RrnaAD PF00398.20 EMD68590.1 - 9.2e-10 38.0 0.0 2e-09 36.9 0.0 1.5 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase APH PF01636.23 EMD68591.1 - 9.4e-09 35.5 0.0 1.5e-08 34.9 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family THUMP PF02926.17 EMD68592.1 - 4.8e-13 49.4 0.0 8e-13 48.7 0.0 1.3 1 0 0 1 1 1 1 THUMP domain SR-25 PF10500.9 EMD68593.1 - 3.1 7.3 32.1 7.7 6.1 23.5 2.3 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein zf-rbx1 PF12678.7 EMD68594.1 - 5.4e-09 36.2 3.8 1.1e-08 35.3 3.8 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 EMD68594.1 - 1.5e-08 34.8 3.4 1.5e-08 34.8 3.4 2.1 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.25 EMD68594.1 - 1.7e-06 27.8 1.7 3.7e-06 26.7 1.7 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EMD68594.1 - 8.2e-06 25.7 1.1 2.4e-05 24.2 1.2 1.7 1 1 1 2 2 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EMD68594.1 - 1.7e-05 24.7 1.0 3.2e-05 23.8 1.0 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EMD68594.1 - 2.4e-05 24.1 5.8 0.00012 21.8 1.4 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 EMD68594.1 - 6.3e-05 22.5 1.0 0.00014 21.4 1.0 1.5 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-C3HC4_2 PF13923.6 EMD68594.1 - 8.5e-05 22.3 2.9 8.5e-05 22.3 2.9 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EMD68594.1 - 0.018 14.9 5.3 0.052 13.4 5.3 1.7 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 EMD68594.1 - 0.02 15.0 1.1 0.051 13.8 1.1 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_11 PF17123.5 EMD68594.1 - 0.033 13.9 0.9 0.11 12.2 0.1 2.1 2 0 0 2 2 2 0 RING-like zinc finger zf-3CxxC_2 PF17180.4 EMD68594.1 - 0.06 14.1 4.1 1 10.1 1.0 2.4 1 1 1 2 2 2 0 Zinc-binding domain zf-ANAPC11 PF12861.7 EMD68594.1 - 0.1 12.6 3.2 0.26 11.4 3.2 1.7 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.6 EMD68594.1 - 1.5 8.7 5.1 0.47 10.3 1.4 1.9 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain Glyco_hydro_32N PF00251.20 EMD68595.1 - 3.7e-45 154.8 6.1 1.8e-44 152.5 6.1 2.0 1 1 0 1 1 1 1 Glycosyl hydrolases family 32 N-terminal domain Glyco_hydro_32C PF08244.12 EMD68595.1 - 6.6e-29 100.9 0.0 1.1e-28 100.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 C terminal DUF4975 PF16346.5 EMD68595.1 - 0.0015 18.7 0.1 0.0028 17.8 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4975) BNR PF02012.20 EMD68595.1 - 0.044 13.8 0.1 0.26 11.4 0.1 2.5 1 0 0 1 1 1 0 BNR/Asp-box repeat Thioredoxin PF00085.20 EMD68597.1 - 1.9e-63 210.9 3.0 3.2e-31 107.4 0.1 4.0 4 1 0 4 4 4 2 Thioredoxin Thioredoxin_6 PF13848.6 EMD68597.1 - 1.1e-47 162.4 1.2 6.1e-33 114.3 0.1 3.3 2 1 1 3 3 3 3 Thioredoxin-like domain Calsequestrin PF01216.17 EMD68597.1 - 1.4e-09 37.5 0.6 1.4e-09 37.5 0.6 1.9 2 0 0 2 2 2 1 Calsequestrin Thioredoxin_2 PF13098.6 EMD68597.1 - 6.7e-09 36.2 0.4 0.0011 19.4 0.0 3.2 2 1 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_7 PF13899.6 EMD68597.1 - 4e-08 33.3 4.1 0.0021 18.2 0.0 3.5 3 0 0 3 3 2 2 Thioredoxin-like OST3_OST6 PF04756.13 EMD68597.1 - 6.4e-08 32.3 0.3 0.0096 15.3 0.0 3.2 2 1 1 3 3 3 2 OST3 / OST6 family, transporter family Thioredoxin_8 PF13905.6 EMD68597.1 - 6.6e-08 32.8 0.0 0.022 15.0 0.0 4.1 3 1 1 4 4 4 2 Thioredoxin-like AhpC-TSA PF00578.21 EMD68597.1 - 3.8e-06 26.8 0.2 0.048 13.6 0.1 3.2 3 0 0 3 3 3 2 AhpC/TSA family Redoxin PF08534.10 EMD68597.1 - 2e-05 24.4 2.0 0.042 13.6 0.0 3.5 3 0 0 3 3 3 2 Redoxin ERp29_N PF07912.13 EMD68597.1 - 5.2e-05 23.4 0.4 0.33 11.1 0.0 4.1 3 2 0 3 3 3 1 ERp29, N-terminal domain DUF883 PF05957.13 EMD68597.1 - 0.34 11.5 12.9 0.83 10.3 12.9 1.7 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF883) Exotox-A_target PF09102.10 EMD68597.1 - 0.84 9.6 7.6 1.7 8.6 7.6 1.5 1 0 0 1 1 1 0 Exotoxin A, targeting YtxH PF12732.7 EMD68597.1 - 0.85 10.2 20.2 2 9.0 17.3 3.1 2 1 0 2 2 2 0 YtxH-like protein CT47 PF15623.6 EMD68597.1 - 1.8 8.3 17.5 3.4 7.4 17.5 1.4 1 0 0 1 1 1 0 Cancer/testis gene family 47 DUF2884 PF11101.8 EMD68597.1 - 2.5 7.6 7.3 2.6 7.5 4.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2884) ISG65-75 PF11727.8 EMD68597.1 - 5.3 6.2 16.3 9.3 5.4 16.3 1.3 1 0 0 1 1 1 0 Invariant surface glycoprotein RRF PF01765.19 EMD68597.1 - 6.8 6.6 11.8 56 3.6 9.9 2.5 2 0 0 2 2 2 0 Ribosome recycling factor Pyrid_ox_like PF16242.5 EMD68598.1 - 8.5e-19 67.6 0.0 1.7e-18 66.6 0.0 1.4 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase like Putative_PNPOx PF01243.20 EMD68598.1 - 3.2e-06 27.2 0.0 7e-06 26.1 0.0 1.6 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase CH PF00307.31 EMD68598.1 - 4.8e-06 26.7 0.0 5.7e-05 23.2 0.0 2.6 2 0 0 2 2 2 1 Calponin homology (CH) domain IQ PF00612.27 EMD68598.1 - 6.9e-05 22.3 14.8 0.0023 17.6 1.4 3.8 3 0 0 3 3 3 2 IQ calmodulin-binding motif RPN7 PF10602.9 EMD68599.1 - 0.11 12.2 0.0 0.23 11.1 0.0 1.5 1 0 0 1 1 1 0 26S proteasome subunit RPN7 SAPS PF04499.15 EMD68599.1 - 0.48 9.1 5.4 0.54 9.0 5.4 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein SDA1 PF05285.12 EMD68599.1 - 0.65 9.4 20.4 0.85 9.0 20.4 1.1 1 0 0 1 1 1 0 SDA1 Raftlin PF15250.6 EMD68599.1 - 3.3 6.3 8.2 12 4.5 5.6 2.1 2 0 0 2 2 2 0 Raftlin CDC45 PF02724.14 EMD68599.1 - 3.5 5.8 15.1 4.5 5.4 15.1 1.1 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 EMD68599.1 - 6.4 4.8 20.8 8.2 4.5 20.8 1.1 1 0 0 1 1 1 0 Nop14-like family RR_TM4-6 PF06459.12 EMD68599.1 - 6.9 6.4 11.7 11 5.8 11.7 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Vfa1 PF08432.10 EMD68599.1 - 8.4 6.7 14.5 14 6.0 14.5 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Mon1 PF03164.14 EMD68600.1 - 1.1e-114 383.7 0.0 1.4e-114 383.3 0.0 1.1 1 0 0 1 1 1 1 Trafficking protein Mon1 Epimerase PF01370.21 EMD68601.1 - 2.7e-06 27.0 0.0 4.1e-06 26.4 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 EMD68601.1 - 0.0014 17.9 0.0 0.0022 17.2 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein RmlD_sub_bind PF04321.17 EMD68601.1 - 0.13 11.3 0.0 0.21 10.7 0.0 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain Mrx7 PF10906.8 EMD68602.1 - 2.7e-09 37.1 0.1 4.3e-09 36.5 0.1 1.3 1 1 0 1 1 1 1 MIOREX complex component 7 Y_phosphatase PF00102.27 EMD68603.1 - 2.9e-56 190.7 0.0 3.6e-56 190.3 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 EMD68603.1 - 0.0018 18.1 0.3 0.0093 15.8 0.1 2.3 2 1 1 3 3 3 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 EMD68603.1 - 0.15 12.0 0.0 0.25 11.3 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family Zn_clus PF00172.18 EMD68605.1 - 6.7e-09 35.7 13.4 1.1e-08 35.1 13.4 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF4132 PF13569.6 EMD68605.1 - 0.065 13.0 0.0 0.098 12.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4132) Aldose_epim PF01263.20 EMD68606.1 - 2.7e-58 197.7 0.1 3.4e-58 197.3 0.1 1.1 1 0 0 1 1 1 1 Aldose 1-epimerase JAB PF01398.21 EMD68607.1 - 1.5e-15 57.2 0.1 5.1e-15 55.5 0.0 1.9 3 0 0 3 3 3 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease USP8_dimer PF08969.11 EMD68607.1 - 1.6e-07 31.5 1.1 3.2e-07 30.5 1.1 1.5 1 0 0 1 1 1 1 USP8 dimerisation domain Prok-JAB PF14464.6 EMD68607.1 - 0.00015 21.6 0.0 0.00034 20.4 0.0 1.6 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain DUF1096 PF06493.11 EMD68607.1 - 0.061 13.8 0.1 0.16 12.4 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1096) DUF2396 PF09654.10 EMD68607.1 - 0.091 12.9 0.1 0.2 11.7 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2396) WDCP PF15390.6 EMD68607.1 - 1.4 7.2 3.0 1.9 6.8 3.0 1.1 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family Pkr1 PF08636.10 EMD68608.1 - 1.8e-33 114.5 5.4 2.3e-33 114.1 5.4 1.1 1 0 0 1 1 1 1 ER protein Pkr1 Trypan_PARP PF05887.11 EMD68608.1 - 0.0059 16.6 0.8 0.0092 16.0 0.8 1.3 1 0 0 1 1 1 1 Procyclic acidic repetitive protein (PARP) FHIPEP PF00771.20 EMD68608.1 - 0.077 11.5 0.0 0.096 11.1 0.0 1.0 1 0 0 1 1 1 0 FHIPEP family Phage_Gp23 PF10669.9 EMD68608.1 - 0.16 12.3 0.0 0.24 11.7 0.0 1.5 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) Totivirus_coat PF05518.11 EMD68608.1 - 1.6 6.7 5.3 2.1 6.3 5.3 1.1 1 0 0 1 1 1 0 Totivirus coat protein adh_short PF00106.25 EMD68609.1 - 1.4e-05 24.6 0.0 6.1e-05 22.6 0.0 1.8 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD68609.1 - 0.0041 16.7 0.0 0.057 13.0 0.0 2.1 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase 2-oxoacid_dh PF00198.23 EMD68612.1 - 7.1e-79 264.5 0.1 1e-78 264.0 0.1 1.3 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 EMD68612.1 - 8.4e-19 67.2 3.2 1.7e-18 66.2 3.2 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme HlyD_3 PF13437.6 EMD68612.1 - 0.00019 22.1 0.6 0.36 11.5 0.1 2.5 1 1 1 2 2 2 2 HlyD family secretion protein Biotin_lipoyl_2 PF13533.6 EMD68612.1 - 0.00045 20.0 0.3 0.43 10.4 0.0 2.4 1 1 1 2 2 2 2 Biotin-lipoyl like GCV_H PF01597.19 EMD68612.1 - 0.088 12.7 0.5 0.19 11.7 0.5 1.6 1 0 0 1 1 1 0 Glycine cleavage H-protein Coilin_N PF15862.5 EMD68612.1 - 0.13 12.1 1.5 0.33 10.7 1.5 1.6 1 1 0 1 1 1 0 Coilin N-terminus RnfC_N PF13375.6 EMD68612.1 - 0.16 11.9 1.7 3.5 7.6 0.0 2.9 2 1 1 3 3 3 0 RnfC Barrel sandwich hybrid domain Presenilin PF01080.17 EMD68612.1 - 0.19 10.5 9.1 0.27 10.0 9.1 1.1 1 0 0 1 1 1 0 Presenilin DUF1387 PF07139.11 EMD68612.1 - 0.33 10.7 9.4 0.47 10.1 9.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) GAGA_bind PF06217.12 EMD68612.1 - 0.61 10.3 7.6 0.87 9.8 7.6 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family FAM76 PF16046.5 EMD68612.1 - 1.3 8.3 8.8 26 4.1 0.0 2.1 2 0 0 2 2 2 0 FAM76 protein Raftlin PF15250.6 EMD68612.1 - 2.1 7.0 7.6 2.9 6.5 7.6 1.1 1 0 0 1 1 1 0 Raftlin Apt1 PF10351.9 EMD68612.1 - 2.4 6.9 7.9 3.4 6.4 7.9 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Mitofilin PF09731.9 EMD68612.1 - 2.5 6.8 15.5 4.1 6.1 15.5 1.4 1 0 0 1 1 1 0 Mitochondrial inner membrane protein CDC45 PF02724.14 EMD68612.1 - 2.5 6.3 8.0 3.4 5.9 8.0 1.1 1 0 0 1 1 1 0 CDC45-like protein NPR3 PF03666.13 EMD68612.1 - 4.4 6.0 8.6 6 5.5 8.6 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Ndc1_Nup PF09531.10 EMD68612.1 - 8.6 4.9 10.2 12 4.4 10.2 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Sugar_tr PF00083.24 EMD68613.1 - 1.2e-81 274.9 28.6 1.6e-81 274.5 28.6 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD68613.1 - 2.5e-18 66.1 43.6 1e-14 54.2 15.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF1279 PF06916.13 EMD68613.1 - 0.037 14.6 0.9 8.4 7.0 1.0 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF1279) Dynein_AAA_lid PF17852.1 EMD68613.1 - 0.077 13.1 2.1 4.8 7.3 0.2 2.9 3 0 0 3 3 3 0 Dynein heavy chain AAA lid domain SGL PF08450.12 EMD68614.1 - 6.1e-46 157.0 0.0 7.6e-46 156.7 0.0 1.0 1 0 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region NHL PF01436.21 EMD68614.1 - 2.9e-10 39.7 0.0 0.025 14.6 0.0 5.8 6 0 0 6 6 6 2 NHL repeat Str_synth PF03088.16 EMD68614.1 - 3.6e-07 30.2 0.0 0.00036 20.6 0.0 3.4 3 1 0 3 3 3 1 Strictosidine synthase Arylesterase PF01731.20 EMD68614.1 - 1.7e-06 28.1 0.0 0.0017 18.5 0.0 3.5 3 1 0 3 3 3 1 Arylesterase Lactonase PF10282.9 EMD68614.1 - 0.00056 19.3 0.0 0.0037 16.6 0.0 2.1 1 1 1 2 2 2 1 Lactonase, 7-bladed beta-propeller Ldl_recept_b PF00058.17 EMD68614.1 - 0.18 12.3 0.1 71 4.0 0.0 4.0 4 0 0 4 4 4 0 Low-density lipoprotein receptor repeat class B Lgl_C PF08596.10 EMD68615.1 - 2.2e-119 398.7 0.0 5.4e-119 397.4 0.0 1.6 2 0 0 2 2 2 1 Lethal giant larvae(Lgl) like, C-terminal ANAPC4_WD40 PF12894.7 EMD68615.1 - 9.7e-08 32.2 0.0 0.089 13.1 0.0 6.1 5 2 1 7 7 7 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EMD68615.1 - 2.9e-07 31.1 0.0 0.0056 17.5 0.0 4.1 4 0 0 4 4 4 2 WD domain, G-beta repeat KASH_CCD PF14662.6 EMD68616.1 - 5.3e-06 26.4 17.3 5.3e-06 26.4 17.3 1.8 2 0 0 2 2 2 1 Coiled-coil region of CCDC155 or KASH YabA PF06156.13 EMD68616.1 - 0.0038 17.8 18.1 0.013 16.1 3.1 3.2 2 1 1 3 3 3 2 Initiation control protein YabA HAP1_N PF04849.13 EMD68616.1 - 0.087 12.0 19.5 0.36 10.0 7.4 2.5 1 1 1 2 2 2 0 HAP1 N-terminal conserved region bZIP_1 PF00170.21 EMD68616.1 - 0.35 11.0 16.8 0.2 11.8 1.3 4.6 3 2 2 5 5 5 0 bZIP transcription factor Cep57_CLD_2 PF14197.6 EMD68616.1 - 0.4 10.8 15.3 2.6 8.2 3.3 2.9 1 1 1 2 2 2 0 Centrosome localisation domain of PPC89 Phlebovirus_NSM PF07246.11 EMD68616.1 - 0.41 10.0 12.2 0.26 10.6 7.2 2.1 1 1 1 2 2 2 0 Phlebovirus nonstructural protein NS-M GIT_CC PF16559.5 EMD68616.1 - 0.47 10.4 14.4 1.8 8.5 1.8 3.0 3 0 0 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor DUF4407 PF14362.6 EMD68616.1 - 1.5 8.1 19.6 1.4 8.2 11.0 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Shugoshin_N PF07558.11 EMD68616.1 - 2.2 8.2 7.7 0.68 9.9 2.0 3.1 2 1 0 2 2 2 0 Shugoshin N-terminal coiled-coil region TPR_MLP1_2 PF07926.12 EMD68616.1 - 3.3 7.8 24.6 1.8 8.6 20.0 2.9 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein APG6_N PF17675.1 EMD68616.1 - 4.5 7.8 28.9 2.1 8.9 4.7 3.0 2 2 1 3 3 3 0 Apg6 coiled-coil region ADIP PF11559.8 EMD68616.1 - 6.3 6.9 36.6 0.038 14.1 6.8 2.8 3 1 1 4 4 4 0 Afadin- and alpha -actinin-Binding RNA_polI_A34 PF08208.11 EMD68617.1 - 2.6e-47 161.6 10.1 2.6e-47 161.6 10.1 3.4 2 1 1 3 3 3 1 DNA-directed RNA polymerase I subunit RPA34.5 CLP1_P PF16575.5 EMD68618.1 - 5.5e-14 52.4 0.0 1e-13 51.5 0.0 1.5 1 1 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_22 PF13401.6 EMD68618.1 - 0.0051 17.1 0.0 0.012 15.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EMD68618.1 - 0.041 14.3 0.0 0.1 13.0 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain AAA_33 PF13671.6 EMD68618.1 - 0.067 13.4 0.2 0.16 12.1 0.2 1.6 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EMD68618.1 - 0.081 13.5 0.0 0.22 12.0 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 EMD68618.1 - 0.086 12.4 0.0 0.16 11.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain cobW PF02492.19 EMD68618.1 - 0.09 12.4 0.5 0.16 11.5 0.5 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_29 PF13555.6 EMD68618.1 - 0.1 12.4 0.2 0.31 10.8 0.2 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain TsaE PF02367.17 EMD68618.1 - 0.12 12.4 0.1 0.33 10.9 0.0 1.7 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Zeta_toxin PF06414.12 EMD68618.1 - 0.18 11.1 0.0 0.49 9.6 0.0 1.7 2 0 0 2 2 2 0 Zeta toxin GP67 PF17634.2 EMD68618.1 - 0.23 11.9 0.1 0.61 10.5 0.1 1.6 1 0 0 1 1 1 0 Gene product 67 Complex1_LYR PF05347.15 EMD68619.1 - 1.2e-09 38.0 1.7 1.6e-09 37.6 1.7 1.2 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 EMD68619.1 - 0.22 12.3 2.2 0.35 11.7 2.1 1.4 1 1 0 1 1 1 0 Complex1_LYR-like Histone_H2A_C PF16211.5 EMD68620.1 - 2.8e-21 74.9 2.6 5e-21 74.1 2.6 1.4 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 EMD68620.1 - 6.9e-17 62.0 0.0 9.1e-17 61.6 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EMD68620.1 - 1e-05 25.7 0.0 1.4e-05 25.3 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EMD68621.1 - 4e-23 82.2 0.4 4.9e-23 81.9 0.4 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EMD68621.1 - 7.3e-05 23.0 1.0 0.0001 22.5 0.0 1.7 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 EMD68621.1 - 0.00026 21.4 0.0 0.00044 20.7 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A DUF1018 PF06252.12 EMD68621.1 - 0.028 15.4 0.4 0.039 15.0 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1018) RP-C PF03428.13 EMD68621.1 - 0.059 13.0 0.1 0.14 11.8 0.1 1.5 1 1 0 1 1 1 0 Replication protein C N-terminal domain Peptidase_C54 PF03416.19 EMD68622.1 - 2.6e-97 325.6 0.0 3.2e-97 325.3 0.0 1.1 1 0 0 1 1 1 1 Peptidase family C54 R3H PF01424.22 EMD68623.1 - 5.1e-14 52.0 0.0 9.5e-14 51.1 0.0 1.4 1 0 0 1 1 1 1 R3H domain G-patch PF01585.23 EMD68623.1 - 1.7e-09 37.4 0.5 1.9e-08 34.1 0.4 2.5 2 0 0 2 2 2 1 G-patch domain Chromo PF00385.24 EMD68623.1 - 0.0001 22.1 0.0 0.00064 19.6 0.0 2.3 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain G-patch_2 PF12656.7 EMD68623.1 - 0.019 15.0 2.7 0.27 11.4 0.5 3.6 3 1 0 3 3 3 0 G-patch domain DNA_pol_phi PF04931.13 EMD68623.1 - 4.4 5.3 26.5 11 4.0 26.5 1.5 1 0 0 1 1 1 0 DNA polymerase phi TRAP_alpha PF03896.16 EMD68623.1 - 9.5 5.3 9.7 24 4.0 9.7 1.6 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit zf-MYND PF01753.18 EMD68624.1 - 1.7e-08 34.4 13.3 3.4e-08 33.4 13.3 1.5 1 0 0 1 1 1 1 MYND finger MRF_C1 PF13887.6 EMD68624.1 - 0.02 14.1 0.0 0.033 13.3 0.0 1.3 1 0 0 1 1 1 0 Myelin gene regulatory factor -C-terminal domain 1 zf-HIT PF04438.16 EMD68624.1 - 0.053 13.4 9.7 0.21 11.5 9.7 2.0 1 1 0 1 1 1 0 HIT zinc finger DUF4259 PF14078.6 EMD68624.1 - 0.064 14.0 0.1 0.12 13.2 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4259) zf-C6H2 PF15801.5 EMD68624.1 - 0.98 9.8 10.7 2 8.8 10.7 1.4 1 0 0 1 1 1 0 zf-MYND-like zinc finger, mRNA-binding DUF2985 PF11204.8 EMD68625.1 - 1.7e-21 76.1 3.7 3.8e-21 75.0 3.7 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2985) Sec-ASP3 PF15432.6 EMD68625.1 - 0.13 12.4 0.1 0.63 10.2 0.0 2.1 2 0 0 2 2 2 0 Accessory Sec secretory system ASP3 HTH_Tnp_Tc5 PF03221.16 EMD68627.1 - 2.4e-09 37.1 0.0 4.4e-09 36.3 0.0 1.5 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EMD68627.1 - 0.00079 19.1 0.1 0.0012 18.5 0.1 1.3 1 0 0 1 1 1 1 helix-turn-helix, Psq domain TnsD PF15978.5 EMD68627.1 - 0.015 14.3 0.1 0.017 14.1 0.1 1.1 1 0 0 1 1 1 0 Tn7-like transposition protein D Ribosomal_S13_N PF08069.12 EMD68627.1 - 0.016 15.2 0.0 0.025 14.6 0.0 1.3 1 0 0 1 1 1 0 Ribosomal S13/S15 N-terminal domain Cdc6_C PF09079.11 EMD68627.1 - 0.029 14.3 0.0 4.7 7.2 0.0 2.2 2 0 0 2 2 2 0 CDC6, C terminal winged helix domain HTH_24 PF13412.6 EMD68627.1 - 0.036 13.6 0.1 0.38 10.4 0.0 2.2 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding DUF3400 PF11880.8 EMD68627.1 - 0.17 11.5 0.0 0.32 10.6 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3400) DUF2721 PF11026.8 EMD68627.1 - 0.24 11.3 1.0 0.34 10.8 1.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2721) CP2 PF04516.15 EMD68631.1 - 4.3e-86 287.9 0.0 6.6e-86 287.3 0.0 1.3 1 0 0 1 1 1 1 CP2 transcription factor Tektin PF03148.14 EMD68631.1 - 0.089 11.5 0.1 0.14 10.9 0.1 1.2 1 0 0 1 1 1 0 Tektin family AKNA PF12443.8 EMD68631.1 - 0.21 12.3 0.2 0.21 12.3 0.2 2.4 3 0 0 3 3 3 0 AT-hook-containing transcription factor CENP-K PF11802.8 EMD68633.1 - 2.2e-05 24.2 9.6 0.074 12.6 0.0 2.4 2 1 0 2 2 2 2 Centromere-associated protein K Trimer_CC PF08954.11 EMD68633.1 - 0.0052 16.3 2.3 0.0052 16.3 2.3 3.3 3 1 1 4 4 4 1 Trimerisation motif 4HB_MCP_1 PF12729.7 EMD68633.1 - 0.17 11.4 4.1 0.76 9.3 0.3 2.6 2 1 0 2 2 2 0 Four helix bundle sensory module for signal transduction Mod_r PF07200.13 EMD68633.1 - 0.36 10.9 20.6 0.25 11.4 10.0 2.3 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein TipAS PF07739.13 EMD68633.1 - 0.67 10.5 12.6 0.079 13.5 4.0 2.9 3 0 0 3 3 3 0 TipAS antibiotic-recognition domain CCDC-167 PF15188.6 EMD68633.1 - 1.9 8.9 7.4 9.2 6.7 2.3 2.7 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 167 KH_1 PF00013.29 EMD68634.1 - 7.7e-42 141.0 5.6 2.1e-18 65.9 0.2 3.3 3 0 0 3 3 3 3 KH domain KH_2 PF07650.17 EMD68634.1 - 6.4e-12 45.1 2.3 0.0036 17.1 0.2 3.3 3 0 0 3 3 3 3 KH domain KH_5 PF13184.6 EMD68634.1 - 1.7e-05 24.8 4.5 0.27 11.3 0.2 3.6 3 0 0 3 3 3 3 NusA-like KH domain MOEP19 PF16005.5 EMD68634.1 - 6.5e-05 22.9 0.0 0.02 14.9 0.0 2.6 3 0 0 3 3 3 2 KH-like RNA-binding domain KH_4 PF13083.6 EMD68634.1 - 0.00056 19.7 2.9 1.7 8.6 0.1 3.7 4 0 0 4 4 4 2 KH domain Lipase PF00151.19 EMD68635.1 - 0.017 14.5 4.1 0.027 13.8 4.1 1.2 1 0 0 1 1 1 0 Lipase DUF3450 PF11932.8 EMD68635.1 - 0.098 12.0 29.2 0.051 12.9 4.2 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF3450) AroM PF07302.11 EMD68635.1 - 0.13 11.6 0.6 0.31 10.4 0.4 1.7 1 1 0 1 1 1 0 AroM protein Baculo_PEP_C PF04513.12 EMD68635.1 - 0.57 10.2 6.2 10 6.2 0.9 2.5 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Ecm29 PF13001.7 EMD68636.1 - 0.16 10.6 0.0 0.2 10.3 0.0 1.1 1 0 0 1 1 1 0 Proteasome stabiliser 4HBT_2 PF13279.6 EMD68637.1 - 6.1e-32 110.7 0.0 8.7e-32 110.2 0.0 1.2 1 0 0 1 1 1 1 Thioesterase-like superfamily 4HBT PF03061.22 EMD68637.1 - 0.023 15.0 0.0 0.058 13.8 0.0 1.7 1 1 0 1 1 1 0 Thioesterase superfamily Methyltransf_25 PF13649.6 EMD68638.1 - 3.3e-13 50.2 0.0 6.8e-13 49.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMD68638.1 - 7.3e-11 42.6 0.0 1.3e-10 41.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMD68638.1 - 1.3e-07 31.5 0.0 2.3e-07 30.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EMD68638.1 - 2.1e-07 30.9 0.0 7.1e-07 29.2 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMD68638.1 - 1.6e-06 28.8 0.0 3.2e-06 27.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EMD68638.1 - 4.6e-06 26.1 0.0 8e-06 25.4 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_8 PF05148.15 EMD68638.1 - 0.0038 17.1 0.0 0.0057 16.5 0.0 1.2 1 0 0 1 1 1 1 Hypothetical methyltransferase MTS PF05175.14 EMD68638.1 - 0.21 11.1 0.0 0.4 10.2 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain Exo_endo_phos PF03372.23 EMD68639.1 - 5.4e-21 75.2 1.5 3.5e-20 72.5 1.5 2.2 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family LRR_8 PF13855.6 EMD68639.1 - 3.7e-09 36.2 11.3 5.1e-08 32.6 9.9 2.7 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 EMD68639.1 - 7.4e-08 32.6 9.2 0.00022 21.5 2.1 2.7 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) DUF3921 PF13060.6 EMD68639.1 - 0.0046 17.0 0.1 0.01 15.8 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3921) TFIIA PF03153.13 EMD68639.1 - 0.12 12.4 15.2 0.17 11.8 15.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit LRR_9 PF14580.6 EMD68639.1 - 0.76 9.3 2.8 2.6 7.5 2.9 1.6 1 1 0 1 1 1 0 Leucine-rich repeat LRR_1 PF00560.33 EMD68639.1 - 2.6 8.9 6.3 80 4.4 3.0 4.3 4 1 0 4 4 4 0 Leucine Rich Repeat CRAL_TRIO PF00650.20 EMD68640.1 - 6.1e-37 126.8 0.0 9.4e-37 126.2 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EMD68640.1 - 4.2e-07 30.0 0.1 9.8e-07 28.9 0.1 1.6 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 EMD68640.1 - 0.00088 19.4 0.0 0.0015 18.7 0.0 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain Mito_carr PF00153.27 EMD68641.1 - 7.6e-52 173.2 3.1 9.2e-21 73.6 0.0 4.0 4 0 0 4 4 4 4 Mitochondrial carrier protein MAM33 PF02330.16 EMD68642.1 - 4.6e-74 248.9 5.3 1.5e-73 247.2 5.3 1.7 1 1 0 1 1 1 1 Mitochondrial glycoprotein Big_8 PF17961.1 EMD68642.1 - 0.046 13.9 0.2 0.12 12.5 0.2 1.7 2 0 0 2 2 2 0 Bacterial Ig domain DUF1410 PF07198.11 EMD68642.1 - 0.16 12.5 1.2 0.32 11.5 1.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1410) BTB PF00651.31 EMD68643.1 - 1.7e-10 41.1 0.0 2.6e-10 40.5 0.0 1.2 1 0 0 1 1 1 1 BTB/POZ domain HUN PF08729.10 EMD68645.1 - 1.4e-07 31.4 0.3 2.7e-07 30.5 0.3 1.5 1 0 0 1 1 1 1 HPC2 and ubinuclein domain Nop PF01798.18 EMD68646.1 - 3.1e-87 291.8 0.1 3.1e-87 291.8 0.1 1.8 3 0 0 3 3 3 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 EMD68646.1 - 1.7e-17 63.5 0.0 1.7e-17 63.5 0.0 2.5 4 0 0 4 4 4 1 NOP5NT (NUC127) domain RNA_polI_A34 PF08208.11 EMD68646.1 - 0.0098 16.0 23.1 0.016 15.3 23.1 1.3 1 0 0 1 1 1 1 DNA-directed RNA polymerase I subunit RPA34.5 DUF1682 PF07946.14 EMD68646.1 - 0.6 9.3 12.0 8.7 5.5 12.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1682) FancD2 PF14631.6 EMD68646.1 - 1.8 5.9 13.7 2.4 5.4 13.7 1.1 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease RP-C_C PF11800.8 EMD68646.1 - 2 8.5 11.2 0.96 9.5 0.2 2.4 2 0 0 2 2 2 0 Replication protein C C-terminal region NARP1 PF12569.8 EMD68646.1 - 4 6.2 21.0 8.1 5.2 21.0 1.5 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Cpn60_TCP1 PF00118.24 EMD68647.1 - 9.5e-167 555.5 1.1 1.1e-166 555.3 1.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Glyco_hydro_47 PF01532.20 EMD68648.1 - 6.7e-197 654.9 0.0 7.9e-197 654.7 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Glyco_hydro_12 PF01670.16 EMD68649.1 - 1.2e-61 208.4 8.3 1.4e-61 208.2 8.3 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 12 Defensin_int PF17858.1 EMD68650.1 - 0.0055 16.7 0.8 0.0068 16.4 0.4 1.4 1 1 0 1 1 1 1 Platypus intermediate defensin-like peptide MARVEL PF01284.23 EMD68650.1 - 0.042 13.9 0.1 0.046 13.7 0.1 1.0 1 0 0 1 1 1 0 Membrane-associating domain GTP_EFTU PF00009.27 EMD68651.1 - 3.7e-32 111.4 3.6 2.6e-30 105.4 3.6 2.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 EMD68651.1 - 6.2e-26 90.6 0.4 1.4e-25 89.5 0.4 1.6 1 0 0 1 1 1 1 Translation-initiation factor 2 IF2_N PF04760.15 EMD68651.1 - 5.8e-10 38.8 0.4 1.7e-09 37.4 0.0 2.0 2 0 0 2 2 2 1 Translation initiation factor IF-2, N-terminal region MMR_HSR1 PF01926.23 EMD68651.1 - 2.1e-09 37.5 0.2 5e-09 36.2 0.2 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EMD68651.1 - 3.2e-05 23.9 0.2 0.00094 19.1 0.0 2.4 1 1 1 2 2 2 1 RsgA GTPase FeoB_N PF02421.18 EMD68651.1 - 0.00011 21.8 0.0 0.00025 20.6 0.0 1.7 1 0 0 1 1 1 1 Ferrous iron transport protein B Arf PF00025.21 EMD68651.1 - 0.00024 20.6 0.0 0.00041 19.8 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EMD68651.1 - 0.00038 20.0 0.9 0.0023 17.4 0.2 2.5 2 1 0 2 2 2 1 Signal recognition particle receptor beta subunit GTP_EFTU_D2 PF03144.25 EMD68651.1 - 0.0038 17.6 7.8 0.69 10.3 0.2 3.6 3 0 0 3 3 3 2 Elongation factor Tu domain 2 Roc PF08477.13 EMD68651.1 - 0.027 14.7 0.0 0.052 13.8 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU_D4 PF14578.6 EMD68651.1 - 0.031 14.2 2.5 0.54 10.2 0.5 2.6 2 0 0 2 2 2 0 Elongation factor Tu domain 4 Dynamin_N PF00350.23 EMD68651.1 - 0.036 14.1 1.4 6.9 6.7 0.1 3.4 2 1 1 3 3 3 0 Dynamin family ATP_bind_1 PF03029.17 EMD68651.1 - 0.085 12.6 0.0 0.19 11.5 0.0 1.7 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein zf-CCHC PF00098.23 EMD68651.1 - 0.38 10.9 5.0 0.14 12.3 1.6 2.1 2 0 0 2 2 2 0 Zinc knuckle Cu_bind_like PF02298.17 EMD68652.1 - 0.049 13.7 0.3 0.25 11.4 0.3 2.0 1 1 0 1 1 1 0 Plastocyanin-like domain p450 PF00067.22 EMD68653.1 - 6.4e-55 186.7 0.0 8.3e-55 186.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Prenylcys_lyase PF07156.14 EMD68654.1 - 1.1e-106 357.0 0.1 1.4e-106 356.6 0.1 1.1 1 0 0 1 1 1 1 Prenylcysteine lyase Amino_oxidase PF01593.24 EMD68654.1 - 1.7e-14 54.0 0.0 2.6e-06 27.0 0.0 2.4 3 0 0 3 3 3 2 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EMD68654.1 - 1.6e-11 44.3 0.1 4.6e-11 42.8 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EMD68654.1 - 6e-10 39.2 0.2 1.5e-06 28.0 0.3 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EMD68654.1 - 1e-08 35.3 0.0 5.8e-05 23.1 0.0 2.3 2 0 0 2 2 2 2 FAD-NAD(P)-binding HI0933_like PF03486.14 EMD68654.1 - 4.6e-06 25.6 0.7 0.042 12.6 0.0 2.2 2 0 0 2 2 2 2 HI0933-like protein Pyr_redox_2 PF07992.14 EMD68654.1 - 5.2e-06 25.9 0.2 0.00087 18.6 0.2 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EMD68654.1 - 0.00028 20.2 0.1 0.38 10.0 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EMD68654.1 - 0.00048 20.6 0.2 0.95 10.1 0.1 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.16 EMD68654.1 - 0.0035 17.0 0.2 0.15 11.7 0.2 2.3 2 0 0 2 2 2 1 Ketopantoate reductase PanE/ApbA FAD_oxidored PF12831.7 EMD68654.1 - 0.0039 16.6 0.2 0.061 12.7 0.1 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase GIDA PF01134.22 EMD68654.1 - 0.0049 16.0 1.1 0.0078 15.3 1.1 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A FAD_binding_3 PF01494.19 EMD68654.1 - 0.0084 15.4 0.1 0.016 14.5 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain FAD_binding_2 PF00890.24 EMD68654.1 - 0.031 13.4 0.5 0.046 12.8 0.5 1.3 1 0 0 1 1 1 0 FAD binding domain MCRA PF06100.11 EMD68654.1 - 0.034 13.0 0.1 0.088 11.6 0.1 1.7 2 0 0 2 2 2 0 MCRA family Thi4 PF01946.17 EMD68654.1 - 0.038 13.2 0.1 0.072 12.3 0.1 1.4 1 0 0 1 1 1 0 Thi4 family AlaDh_PNT_C PF01262.21 EMD68654.1 - 0.097 12.0 0.0 0.19 11.0 0.0 1.5 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain F420_oxidored PF03807.17 EMD68654.1 - 0.12 12.9 0.1 0.71 10.5 0.1 2.2 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent DUF2263 PF10021.9 EMD68656.1 - 4.9e-18 65.9 0.0 1e-17 64.9 0.0 1.5 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2263) Macro PF01661.21 EMD68656.1 - 0.028 14.4 0.0 0.05 13.6 0.0 1.4 1 0 0 1 1 1 0 Macro domain DNA_pol_A_exo1 PF01612.20 EMD68657.1 - 2.3e-37 128.4 0.5 3.7e-37 127.7 0.1 1.6 2 0 0 2 2 2 1 3'-5' exonuclease PMC2NT PF08066.12 EMD68657.1 - 2.7e-26 92.1 0.4 1.4e-25 89.8 0.0 2.4 3 0 0 3 3 3 1 PMC2NT (NUC016) domain HRDC PF00570.23 EMD68657.1 - 1.6e-10 40.8 0.0 5.1e-10 39.2 0.0 2.0 1 0 0 1 1 1 1 HRDC domain UPF0203 PF05254.12 EMD68658.1 - 2.7e-26 91.6 2.6 3.2e-26 91.4 2.6 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0203) COX17 PF05051.13 EMD68658.1 - 0.00013 22.3 0.5 0.00032 21.0 0.5 1.6 1 1 0 1 1 1 1 Cytochrome C oxidase copper chaperone (COX17) Cmc1 PF08583.10 EMD68658.1 - 0.0091 16.0 3.8 0.11 12.6 0.2 2.3 1 1 1 2 2 2 2 Cytochrome c oxidase biogenesis protein Cmc1 like UCR_hinge PF02320.16 EMD68658.1 - 0.011 15.9 3.7 0.63 10.3 0.2 2.2 1 1 1 2 2 2 0 Ubiquinol-cytochrome C reductase hinge protein MAPEG PF01124.18 EMD68659.1 - 7.2e-21 74.5 2.1 8.5e-21 74.2 2.1 1.1 1 0 0 1 1 1 1 MAPEG family VHS PF00790.19 EMD68660.1 - 4.3e-48 162.7 0.2 1.2e-47 161.3 0.0 1.9 2 0 0 2 2 2 1 VHS domain GAT PF03127.14 EMD68660.1 - 1.3e-21 76.7 1.8 6.2e-21 74.5 0.1 3.0 3 0 0 3 3 3 1 GAT domain Alpha_adaptinC2 PF02883.20 EMD68660.1 - 9.7e-19 67.7 2.1 9.7e-19 67.7 2.1 2.3 3 0 0 3 3 3 1 Adaptin C-terminal domain GGA_N-GAT PF18308.1 EMD68660.1 - 1.8e-07 30.7 0.1 2e-06 27.3 0.0 2.7 3 0 0 3 3 3 1 GGA N-GAT domain Mei5 PF10376.9 EMD68660.1 - 0.044 13.6 1.4 0.068 13.0 1.0 1.5 1 1 0 1 1 1 0 Double-strand recombination repair protein Ribo_biogen_C PF04034.13 EMD68661.1 - 5.5e-50 168.4 0.0 8e-50 167.8 0.0 1.3 1 0 0 1 1 1 1 Ribosome biogenesis protein, C-terminal RLI PF04068.15 EMD68661.1 - 2.5e-10 40.0 0.6 5.5e-10 38.9 0.6 1.6 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI BUD22 PF09073.10 EMD68661.1 - 0.0042 16.5 21.0 0.0042 16.5 21.0 1.4 2 0 0 2 2 2 1 BUD22 Nop14 PF04147.12 EMD68661.1 - 3.7 5.6 27.8 0.37 9.0 23.2 1.4 1 1 0 1 1 1 0 Nop14-like family adh_short_C2 PF13561.6 EMD68662.1 - 1.9e-55 187.9 0.5 2.9e-55 187.4 0.5 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EMD68662.1 - 6.2e-49 166.1 3.3 7.7e-49 165.8 3.3 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EMD68662.1 - 1.6e-10 41.2 0.5 2.3e-10 40.7 0.5 1.1 1 0 0 1 1 1 1 KR domain THF_DHG_CYH_C PF02882.19 EMD68662.1 - 0.0074 15.6 0.1 0.018 14.3 0.1 1.6 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain AdoHcyase_NAD PF00670.21 EMD68662.1 - 0.15 12.1 2.6 0.32 11.1 2.6 1.6 1 1 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Zn_clus PF00172.18 EMD68664.1 - 3.2e-08 33.5 13.9 6.4e-08 32.6 13.9 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EMD68664.1 - 1.2e-06 27.7 1.8 3.9e-06 26.1 0.7 2.4 2 1 0 2 2 2 1 Fungal specific transcription factor domain SPX PF03105.19 EMD68664.1 - 0.42 10.5 8.9 0.58 10.0 8.9 1.3 1 0 0 1 1 1 0 SPX domain Apt1 PF10351.9 EMD68664.1 - 6.1 5.6 8.6 9.6 4.9 8.6 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain FAM70 PF14967.6 EMD68664.1 - 7.2 6.0 8.9 15 4.9 8.9 1.5 1 0 0 1 1 1 0 FAM70 protein SAT PF16073.5 EMD68669.1 - 5.7e-84 281.6 1.3 1.9e-83 279.9 0.4 2.5 2 1 0 2 2 2 1 Starter unit:ACP transacylase in aflatoxin biosynthesis ketoacyl-synt PF00109.26 EMD68669.1 - 5.8e-79 265.2 0.0 1.3e-78 264.1 0.0 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 EMD68669.1 - 1.8e-40 139.4 0.0 3.8e-40 138.3 0.0 1.5 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 EMD68669.1 - 2e-33 114.9 2.9 2e-33 114.9 2.9 2.4 3 0 0 3 3 3 1 Beta-ketoacyl synthase, C-terminal domain Thioesterase PF00975.20 EMD68669.1 - 2.6e-24 86.6 0.2 1e-21 78.1 0.0 3.4 4 0 0 4 4 4 1 Thioesterase domain PP-binding PF00550.25 EMD68669.1 - 6.2e-23 80.9 6.9 1.1e-11 44.9 0.4 2.7 2 0 0 2 2 2 2 Phosphopantetheine attachment site PS-DH PF14765.6 EMD68669.1 - 1.6e-13 50.6 0.0 3.6e-13 49.4 0.0 1.6 2 0 0 2 2 2 1 Polyketide synthase dehydratase KAsynt_C_assoc PF16197.5 EMD68669.1 - 4.6e-08 33.5 0.2 2.5e-07 31.1 0.0 2.3 2 0 0 2 2 2 1 Ketoacyl-synthetase C-terminal extension Abhydrolase_6 PF12697.7 EMD68669.1 - 6.8e-05 23.6 2.9 0.0036 17.9 0.1 3.0 3 0 0 3 3 3 1 Alpha/beta hydrolase family Thiolase_N PF00108.23 EMD68669.1 - 0.00034 20.1 0.2 0.0014 18.0 0.0 2.1 2 0 0 2 2 2 1 Thiolase, N-terminal domain Abhydrolase_5 PF12695.7 EMD68669.1 - 0.017 14.9 0.3 2.1 8.1 0.0 2.8 3 0 0 3 3 3 0 Alpha/beta hydrolase family Abhydrolase_3 PF07859.13 EMD68669.1 - 0.067 13.0 0.0 0.2 11.5 0.0 1.7 1 0 0 1 1 1 0 alpha/beta hydrolase fold DUF2974 PF11187.8 EMD68669.1 - 0.099 12.2 0.0 0.22 11.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Prefoldin PF02996.17 EMD68670.1 - 2.3e-35 121.1 0.1 5.1e-35 120.0 0.0 1.5 2 0 0 2 2 2 1 Prefoldin subunit Prefoldin_2 PF01920.20 EMD68670.1 - 0.0002 21.3 0.2 0.011 15.7 0.0 2.6 1 1 1 3 3 3 1 Prefoldin subunit APG17 PF04108.12 EMD68670.1 - 0.0019 17.4 0.4 0.0034 16.6 0.1 1.5 2 0 0 2 2 2 1 Autophagy protein Apg17 Syntaxin-6_N PF09177.11 EMD68670.1 - 0.0019 18.7 2.9 0.6 10.7 2.9 2.2 1 1 0 1 1 1 1 Syntaxin 6, N-terminal DUF1664 PF07889.12 EMD68670.1 - 0.0054 16.8 0.2 1.3 9.1 0.1 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF1664) Filament PF00038.21 EMD68670.1 - 0.01 15.4 0.6 1 8.9 0.1 2.1 2 0 0 2 2 2 0 Intermediate filament protein Lebercilin PF15619.6 EMD68670.1 - 0.024 14.3 1.3 0.84 9.3 0.0 2.1 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease BST2 PF16716.5 EMD68670.1 - 0.048 14.3 0.7 10 6.8 0.1 2.2 2 0 0 2 2 2 0 Bone marrow stromal antigen 2 End3 PF12761.7 EMD68670.1 - 0.049 13.8 0.3 0.2 11.8 0.2 1.9 1 1 1 2 2 2 0 Actin cytoskeleton-regulatory complex protein END3 DUF4795 PF16043.5 EMD68670.1 - 0.05 13.2 0.5 2 7.9 0.3 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4795) THOC7 PF05615.13 EMD68670.1 - 0.14 12.5 1.8 0.89 9.8 0.2 2.1 2 0 0 2 2 2 0 Tho complex subunit 7 CC2-LZ PF16516.5 EMD68670.1 - 0.89 10.0 6.0 7.1 7.1 0.3 2.5 2 1 0 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator UPF0154 PF03672.13 EMD68671.1 - 0.049 13.7 0.7 0.049 13.7 0.7 2.1 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0154) ArgoL1 PF08699.10 EMD68671.1 - 0.081 12.6 0.0 0.19 11.4 0.0 1.6 1 0 0 1 1 1 0 Argonaute linker 1 domain Hamartin PF04388.12 EMD68671.1 - 1.6 7.3 5.7 2.9 6.5 5.7 1.4 1 0 0 1 1 1 0 Hamartin protein Sec34 PF04136.15 EMD68672.1 - 7.5e-51 171.9 0.8 7.5e-51 171.9 0.8 1.7 2 0 0 2 2 2 1 Sec34-like family Mer2 PF09074.10 EMD68672.1 - 0.42 10.4 2.9 0.66 9.8 0.6 2.3 2 0 0 2 2 2 0 Mer2 BST2 PF16716.5 EMD68672.1 - 0.88 10.2 4.2 1 10.0 0.6 2.6 1 1 1 2 2 2 0 Bone marrow stromal antigen 2 RCC1 PF00415.18 EMD68673.1 - 1.1e-30 106.0 1.6 7.2e-06 26.5 0.0 7.7 8 0 0 8 8 8 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EMD68673.1 - 8e-16 57.4 17.8 3.2e-08 33.2 0.0 7.1 7 0 0 7 7 7 4 Regulator of chromosome condensation (RCC1) repeat DnaJ PF00226.31 EMD68675.1 - 4.4e-07 29.9 0.4 9.7e-07 28.8 0.4 1.6 1 0 0 1 1 1 1 DnaJ domain DUF5559 PF17714.1 EMD68675.1 - 0.89 9.4 6.0 0.25 11.2 1.6 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5559) Ribosomal_L31 PF01197.18 EMD68676.1 - 0.0046 17.1 0.0 0.0082 16.4 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L31 Flavin_Reduct PF01613.18 EMD68677.1 - 9.2e-22 77.7 0.2 1.6e-21 77.0 0.2 1.4 1 0 0 1 1 1 1 Flavin reductase like domain PAS_3 PF08447.12 EMD68677.1 - 0.12 12.7 0.0 25 5.3 0.0 2.9 2 0 0 2 2 2 0 PAS fold LSM PF01423.22 EMD68678.1 - 4.1e-18 64.8 0.1 5.1e-18 64.5 0.1 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EMD68678.1 - 0.0021 18.1 0.1 0.0028 17.8 0.1 1.2 1 0 0 1 1 1 1 Ataxin 2 SM domain TauD PF02668.16 EMD68679.1 - 3.1e-28 99.3 0.0 3.9e-28 99.0 0.0 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family TSSC4 PF15264.6 EMD68679.1 - 0.00037 20.8 0.0 0.00071 19.8 0.0 1.4 1 0 0 1 1 1 1 Tumour suppressing sub-chromosomal transferable candidate 4 DUF1744 PF08490.12 EMD68680.1 - 6.6e-153 509.0 0.0 9.5e-153 508.5 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1744) DNA_pol_B_exo1 PF03104.19 EMD68680.1 - 2.9e-82 276.5 2.3 5.6e-82 275.6 2.3 1.5 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_B PF00136.21 EMD68680.1 - 2.3e-16 59.6 2.2 1.2e-13 50.6 0.0 3.7 4 0 0 4 4 4 2 DNA polymerase family B DNA_pol_B_exo2 PF10108.9 EMD68680.1 - 1.9e-09 37.5 0.1 6.2e-09 35.9 0.1 1.8 1 0 0 1 1 1 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB RNase_H_2 PF13482.6 EMD68680.1 - 1.3e-05 25.3 0.1 8.1e-05 22.7 0.0 2.4 2 0 0 2 2 2 1 RNase_H superfamily DUF3767 PF12597.8 EMD68681.1 - 8e-30 102.6 1.1 8.2e-30 102.6 0.1 1.5 1 1 1 2 2 2 1 Protein of unknown function (DUF3767) DUF2370 PF10176.9 EMD68681.1 - 0.14 11.8 0.1 0.55 9.8 0.0 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2370) PBP_sp32 PF07222.12 EMD68681.1 - 0.49 9.8 6.6 0.67 9.4 6.6 1.1 1 0 0 1 1 1 0 Proacrosin binding protein sp32 SHR3_chaperone PF08229.11 EMD68681.1 - 0.61 9.0 2.7 0.52 9.3 1.7 1.4 1 1 0 1 1 1 0 ER membrane protein SH3 MTS PF05175.14 EMD68682.1 - 0.00016 21.3 0.0 0.00027 20.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_12 PF08242.12 EMD68682.1 - 0.016 16.0 0.0 0.027 15.2 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.6 EMD68682.1 - 0.02 15.6 0.0 0.037 14.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Complex1_LYR_2 PF13233.6 EMD68683.1 - 1.3e-19 70.7 0.1 2.3e-19 69.9 0.0 1.4 2 0 0 2 2 2 1 Complex1_LYR-like Complex1_LYR PF05347.15 EMD68683.1 - 5.2e-12 45.6 0.0 1.4e-11 44.2 0.0 1.7 2 0 0 2 2 2 1 Complex 1 protein (LYR family) Ribosomal_L29e PF01779.17 EMD68685.1 - 2.7e-21 75.6 13.2 4.9e-21 74.8 13.2 1.4 1 0 0 1 1 1 1 Ribosomal L29e protein family AMMECR1 PF01871.17 EMD68686.1 - 3.4e-48 163.4 0.0 5.9e-48 162.6 0.0 1.3 2 0 0 2 2 2 1 AMMECR1 Myc_N PF01056.18 EMD68686.1 - 0.016 15.1 2.8 0.021 14.7 2.8 1.1 1 0 0 1 1 1 0 Myc amino-terminal region PPP4R2 PF09184.11 EMD68686.1 - 0.11 12.0 5.2 0.16 11.5 5.2 1.1 1 0 0 1 1 1 0 PPP4R2 Herpes_pp85 PF04637.12 EMD68686.1 - 3.9 5.8 6.0 5.1 5.4 6.0 1.2 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) Peptidase_C14 PF00656.22 EMD68687.1 - 3.8e-61 207.2 0.0 4.8e-61 206.9 0.0 1.1 1 0 0 1 1 1 1 Caspase domain Sec7 PF01369.20 EMD68688.1 - 5.4e-24 84.9 0.1 1.3e-23 83.6 0.0 1.5 2 0 0 2 2 2 1 Sec7 domain PH_9 PF15410.6 EMD68688.1 - 5.8e-19 68.6 0.0 1.6e-18 67.2 0.0 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain CBS PF00571.28 EMD68689.1 - 6.2e-22 77.8 5.1 1.4e-07 31.8 0.0 5.3 5 0 0 5 5 5 5 CBS domain tRNA-synt_2b PF00587.25 EMD68691.1 - 3.8e-31 108.4 0.0 2.6e-28 99.2 0.0 2.8 3 0 0 3 3 3 2 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 EMD68691.1 - 1.1e-17 64.0 0.5 2.4e-17 62.8 0.5 1.6 1 0 0 1 1 1 1 Anticodon binding domain tRNA_SAD PF07973.14 EMD68691.1 - 2e-13 50.2 0.2 4.7e-13 49.0 0.0 1.8 2 0 0 2 2 2 1 Threonyl and Alanyl tRNA synthetase second additional domain TGS PF02824.21 EMD68691.1 - 1.6e-10 40.9 0.0 3.8e-10 39.7 0.0 1.6 1 0 0 1 1 1 1 TGS domain GUN4 PF05419.12 EMD68691.1 - 0.33 11.0 2.4 1.2 9.2 1.2 2.5 2 1 0 2 2 2 0 GUN4-like Gar1 PF04410.14 EMD68692.1 - 2e-36 125.1 0.1 2.4e-36 124.9 0.1 1.0 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region FtsX PF02687.21 EMD68694.1 - 9.6 6.8 16.5 0.41 11.2 4.4 2.6 2 2 0 2 2 2 0 FtsX-like permease family Megourin PF17560.2 EMD68696.1 - 0.066 13.5 0.3 0.066 13.5 0.3 1.7 2 0 0 2 2 2 0 Aphid Megourins Whi5 PF08528.11 EMD68697.1 - 5.1e-09 35.5 0.2 1.6e-08 33.9 0.1 2.0 2 0 0 2 2 2 1 Whi5 like Metallopep PF12044.8 EMD68698.1 - 8.2e-167 555.1 0.0 1e-166 554.8 0.0 1.1 1 0 0 1 1 1 1 Putative peptidase family Reprolysin_2 PF13574.6 EMD68698.1 - 0.076 12.9 0.3 0.15 12.0 0.3 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 EMD68698.1 - 0.54 10.4 3.9 0.16 12.1 0.6 1.8 2 0 0 2 2 2 0 Metallo-peptidase family M12 CDP-OH_P_transf PF01066.21 EMD68699.1 - 2.8e-12 47.2 1.5 3.3e-12 47.0 0.2 1.8 2 0 0 2 2 2 1 CDP-alcohol phosphatidyltransferase Aminotran_1_2 PF00155.21 EMD68700.1 - 1.4e-36 126.4 0.0 1.7e-36 126.2 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Glucan_synthase PF02364.15 EMD68701.1 - 0 1367.0 0.0 0 1366.3 0.0 1.3 1 0 0 1 1 1 1 1,3-beta-glucan synthase component FKS1_dom1 PF14288.6 EMD68701.1 - 1.5e-41 141.7 0.3 4.6e-41 140.2 0.3 1.9 1 1 0 1 1 1 1 1,3-beta-glucan synthase subunit FKS1, domain-1 Glyco_hydro_72 PF03198.14 EMD68702.1 - 2.4e-129 431.1 6.0 3.2e-129 430.7 6.0 1.1 1 0 0 1 1 1 1 Glucanosyltransferase X8 PF07983.13 EMD68702.1 - 2.6e-19 69.7 3.9 6.3e-19 68.5 3.9 1.7 1 0 0 1 1 1 1 X8 domain Gln-synt_C PF00120.24 EMD68703.1 - 6.1e-56 189.9 0.0 2.1e-55 188.1 0.0 1.8 1 1 0 1 1 1 1 Glutamine synthetase, catalytic domain Amidohydro_2 PF04909.14 EMD68703.1 - 4.1e-13 49.8 0.0 8.6e-13 48.7 0.0 1.5 1 0 0 1 1 1 1 Amidohydrolase FUR PF01475.19 EMD68704.1 - 0.13 12.4 0.1 18 5.5 0.0 2.5 2 0 0 2 2 2 0 Ferric uptake regulator family WSC PF01822.19 EMD68705.1 - 9.5e-14 51.4 7.4 2.2e-13 50.2 7.4 1.7 1 0 0 1 1 1 1 WSC domain SKG6 PF08693.10 EMD68705.1 - 1.3e-07 30.9 0.2 1.3e-07 30.9 0.2 2.6 3 0 0 3 3 3 2 Transmembrane alpha-helix domain MGC-24 PF05283.11 EMD68705.1 - 0.00021 21.8 0.3 0.00021 21.8 0.3 2.0 2 0 0 2 2 2 1 Multi-glycosylated core protein 24 (MGC-24), sialomucin DUF4448 PF14610.6 EMD68705.1 - 0.004 17.0 0.0 0.006 16.4 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) DUF1180 PF06679.12 EMD68705.1 - 0.016 15.7 0.2 0.016 15.7 0.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) Phage_HK97_TLTM PF06120.11 EMD68705.1 - 0.027 13.7 0.0 0.038 13.2 0.0 1.1 1 0 0 1 1 1 0 Tail length tape measure protein Adeno_E3_CR2 PF02439.15 EMD68705.1 - 0.045 13.5 0.0 0.093 12.5 0.0 1.5 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Trp_oprn_chp PF09534.10 EMD68705.1 - 0.091 12.6 0.1 0.091 12.6 0.1 1.8 2 0 0 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) PH PF00169.29 EMD68706.1 - 0.00057 20.4 0.0 0.0013 19.2 0.0 1.6 1 0 0 1 1 1 1 PH domain DUF4615 PF15393.6 EMD68706.1 - 0.23 12.0 1.3 0.48 11.0 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4615) Prominin PF05478.11 EMD68706.1 - 0.31 8.9 0.7 0.46 8.4 0.7 1.2 1 0 0 1 1 1 0 Prominin Glyco_hydro_61 PF03443.14 EMD68707.1 - 1.7e-56 191.4 0.1 2.1e-56 191.1 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 TIG PF01833.24 EMD68707.1 - 0.01 15.9 0.7 0.73 9.9 0.1 2.2 2 0 0 2 2 2 0 IPT/TIG domain ADH_zinc_N_2 PF13602.6 EMD68708.1 - 4.6e-13 50.4 0.1 8.4e-13 49.5 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 EMD68708.1 - 1.7e-12 47.5 0.0 3.8e-12 46.3 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EMD68708.1 - 1.5e-05 24.8 0.0 3.4e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain DUF2855 PF11017.8 EMD68708.1 - 0.00056 19.8 0.0 0.00088 19.1 0.0 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF2855) UCH PF00443.29 EMD68709.1 - 2.1e-51 174.9 0.4 5.4e-51 173.6 0.1 1.7 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EMD68709.1 - 4.7e-27 95.4 4.1 7.1e-21 75.1 0.1 2.5 3 0 0 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 EMD68709.1 - 5.5e-06 26.6 1.0 5.5e-06 26.6 1.0 2.7 2 1 0 2 2 2 1 Zn-finger in ubiquitin-hydrolases and other protein Peptidase_C98 PF15499.6 EMD68709.1 - 0.00022 20.8 0.8 3.4 7.1 0.0 3.7 4 0 0 4 4 4 3 Ubiquitin-specific peptidase-like, SUMO isopeptidase COesterase PF00135.28 EMD68711.1 - 2.4e-66 224.7 0.3 3.2e-66 224.3 0.3 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EMD68711.1 - 0.024 14.5 0.6 0.063 13.1 0.1 2.0 2 1 0 2 2 2 0 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EMD68711.1 - 0.12 11.6 0.0 0.19 11.0 0.0 1.2 1 0 0 1 1 1 0 Serine aminopeptidase, S33 NUFIP2 PF15293.6 EMD68711.1 - 0.15 10.9 0.1 0.21 10.4 0.1 1.1 1 0 0 1 1 1 0 Nuclear fragile X mental retardation-interacting protein 2 Gmx_para_CXXCG PF09535.10 EMD68712.1 - 0.071 12.4 0.6 0.1 11.8 0.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (Gmx_para_CXXCG) DUF3431 PF11913.8 EMD68713.1 - 8.3e-11 42.1 0.5 2.3e-10 40.6 0.5 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF3431) MnhB PF04039.13 EMD68713.1 - 0.074 13.4 1.9 12 6.2 0.1 2.7 2 0 0 2 2 2 0 Domain related to MnhB subunit of Na+/H+ antiporter HXXEE PF13787.6 EMD68713.1 - 3 8.7 9.1 24 5.8 3.2 3.2 3 1 0 3 3 3 0 Protein of unknown function with HXXEE motif adh_short PF00106.25 EMD68715.1 - 7.6e-18 64.7 0.0 9e-18 64.4 0.0 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD68715.1 - 2.2e-13 50.3 0.0 2.4e-13 50.2 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD68715.1 - 2.4e-06 27.6 0.0 2.9e-06 27.3 0.0 1.2 1 0 0 1 1 1 1 KR domain Sacchrp_dh_NADP PF03435.18 EMD68715.1 - 0.088 13.1 0.1 0.12 12.6 0.1 1.3 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain GH131_N PF18271.1 EMD68716.1 - 3.2e-66 223.7 0.2 3.6e-66 223.5 0.2 1.0 1 0 0 1 1 1 1 Glycoside hydrolase 131 catalytic N-terminal domain RPAP1_C PF08620.10 EMD68717.1 - 8.1e-27 93.1 0.0 1.7e-26 92.1 0.0 1.6 1 0 0 1 1 1 1 RPAP1-like, C-terminal RPAP1_N PF08621.10 EMD68717.1 - 1.9e-17 62.7 7.0 4.4e-17 61.6 7.0 1.7 1 0 0 1 1 1 1 RPAP1-like, N-terminal Glyoxalase PF00903.25 EMD68718.1 - 7.9e-15 55.2 0.0 1.6e-14 54.2 0.0 1.5 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 EMD68718.1 - 1.3e-08 35.0 0.0 3.2e-08 33.8 0.0 1.7 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 EMD68718.1 - 0.073 13.9 0.0 0.42 11.4 0.0 2.2 1 1 0 1 1 1 0 Glyoxalase-like domain Glyoxalase_3 PF13468.6 EMD68718.1 - 0.095 12.8 0.0 1.4 9.0 0.0 2.0 1 1 0 2 2 2 0 Glyoxalase-like domain RPT PF13446.6 EMD68719.1 - 1.2e-38 130.8 2.3 9e-20 70.4 0.1 4.8 4 0 0 4 4 4 3 A repeated domain in UCH-protein UCH PF00443.29 EMD68719.1 - 6.9e-35 120.8 0.0 1.3e-34 119.9 0.0 1.5 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EMD68719.1 - 2.5e-05 24.0 0.0 0.0014 18.3 0.0 2.3 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Totivirus_coat PF05518.11 EMD68719.1 - 0.53 8.3 6.0 0.81 7.7 6.0 1.2 1 0 0 1 1 1 0 Totivirus coat protein Tim17 PF02466.19 EMD68720.1 - 0.00044 20.6 5.8 0.0011 19.3 5.7 1.8 1 1 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family TBCC PF07986.12 EMD68721.1 - 1.5e-30 105.4 1.5 2.3e-30 104.8 1.5 1.3 1 0 0 1 1 1 1 Tubulin binding cofactor C TBCC_N PF16752.5 EMD68721.1 - 1.7e-11 44.6 0.8 2.7e-11 43.9 0.8 1.3 1 0 0 1 1 1 1 Tubulin-specific chaperone C N-terminal domain Cob_adeno_trans PF01923.18 EMD68721.1 - 0.047 13.8 0.0 0.11 12.6 0.0 1.6 1 0 0 1 1 1 0 Cobalamin adenosyltransferase S-methyl_trans PF02574.16 EMD68724.1 - 5.9e-75 252.5 0.0 6.8e-75 252.3 0.0 1.0 1 0 0 1 1 1 1 Homocysteine S-methyltransferase Med11 PF10280.9 EMD68725.1 - 2.9e-15 56.9 0.0 5.4e-15 56.0 0.0 1.4 1 1 0 1 1 1 1 Mediator complex protein DUF2200 PF09966.9 EMD68725.1 - 0.082 13.0 0.0 0.15 12.2 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2200) WD40 PF00400.32 EMD68726.1 - 3.1e-47 157.6 21.0 5.8e-09 36.4 0.1 6.9 7 0 0 7 7 7 6 WD domain, G-beta repeat TFIID_NTD2 PF04494.15 EMD68726.1 - 5.3e-39 133.4 0.5 7.5e-39 132.9 0.5 1.2 1 0 0 1 1 1 1 WD40 associated region in TFIID subunit, NTD2 domain ANAPC4_WD40 PF12894.7 EMD68726.1 - 6.5e-10 39.2 0.1 0.014 15.7 0.0 5.0 2 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain LisH PF08513.11 EMD68726.1 - 1e-06 28.5 0.1 2.1e-06 27.5 0.1 1.6 1 0 0 1 1 1 1 LisH Nup160 PF11715.8 EMD68726.1 - 1.5e-05 23.9 0.6 0.067 11.8 0.0 3.2 3 0 0 3 3 3 2 Nucleoporin Nup120/160 DUF2283 PF10049.9 EMD68726.1 - 0.029 14.6 0.1 0.13 12.5 0.1 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2283) IKI3 PF04762.12 EMD68726.1 - 0.031 12.3 0.1 0.051 11.6 0.1 1.3 1 0 0 1 1 1 0 IKI3 family Med9 PF07544.13 EMD68727.1 - 2.2e-18 66.1 0.4 3.1e-18 65.6 0.4 1.2 1 0 0 1 1 1 1 RNA polymerase II transcription mediator complex subunit 9 Med21 PF11221.8 EMD68727.1 - 0.0038 17.5 12.2 0.0091 16.3 12.2 1.6 1 1 0 1 1 1 1 Subunit 21 of Mediator complex DUF1993 PF09351.10 EMD68727.1 - 0.014 15.6 0.1 0.018 15.2 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1993) Spc29 PF17082.5 EMD68727.1 - 0.026 14.4 0.1 0.034 14.0 0.1 1.2 1 0 0 1 1 1 0 Spindle Pole Component 29 DUF4618 PF15397.6 EMD68727.1 - 0.027 13.9 0.3 0.036 13.5 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) Spc24 PF08286.11 EMD68727.1 - 0.039 14.2 0.8 0.062 13.5 0.8 1.3 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 Phage_GP20 PF06810.11 EMD68727.1 - 0.05 13.4 0.3 0.067 13.0 0.3 1.1 1 0 0 1 1 1 0 Phage minor structural protein GP20 FlxA PF14282.6 EMD68727.1 - 0.051 13.6 1.0 0.07 13.1 1.0 1.2 1 0 0 1 1 1 0 FlxA-like protein AATF-Che1 PF13339.6 EMD68727.1 - 0.053 14.2 0.2 0.087 13.5 0.2 1.3 1 0 0 1 1 1 0 Apoptosis antagonizing transcription factor DivIC PF04977.15 EMD68727.1 - 0.057 13.2 1.2 0.081 12.7 1.2 1.2 1 0 0 1 1 1 0 Septum formation initiator Formin_GBD_N PF18382.1 EMD68727.1 - 0.084 13.3 0.9 0.15 12.5 0.5 1.7 1 1 1 2 2 2 0 Formin N-terminal GTPase-binding domain SlyX PF04102.12 EMD68727.1 - 0.087 13.4 1.3 0.087 13.4 1.3 2.0 3 0 0 3 3 2 0 SlyX LUC7 PF03194.15 EMD68727.1 - 0.091 12.4 1.4 0.12 12.0 1.4 1.1 1 0 0 1 1 1 0 LUC7 N_terminus zf-ZPR1 PF03367.13 EMD68727.1 - 0.097 12.5 0.1 0.13 12.2 0.1 1.1 1 0 0 1 1 1 0 ZPR1 zinc-finger domain Csm1_N PF18504.1 EMD68727.1 - 0.098 13.0 1.3 0.17 12.2 1.3 1.3 1 0 0 1 1 1 0 Csm1 N-terminal domain Helo_like_N PF17111.5 EMD68727.1 - 0.11 11.9 0.2 0.15 11.4 0.2 1.2 1 0 0 1 1 1 0 Fungal N-terminal domain of STAND proteins AMH_N PF04709.12 EMD68727.1 - 3.7 6.4 8.9 15 4.4 8.9 1.8 1 1 0 1 1 1 0 Anti-Mullerian hormone, N terminal region iPGM_N PF06415.13 EMD68728.1 - 3.4e-76 255.5 0.0 5.9e-76 254.7 0.0 1.4 1 0 0 1 1 1 1 BPG-independent PGAM N-terminus (iPGM_N) Metalloenzyme PF01676.18 EMD68728.1 - 8.7e-75 251.3 0.1 1e-74 251.1 0.1 1.0 1 0 0 1 1 1 1 Metalloenzyme superfamily Sulfatase PF00884.23 EMD68728.1 - 4.3e-06 26.4 0.0 0.00076 19.0 0.0 2.9 2 1 0 2 2 2 2 Sulfatase Phosphodiest PF01663.22 EMD68728.1 - 3.4e-05 23.6 0.0 8.9e-05 22.2 0.0 1.7 2 0 0 2 2 2 1 Type I phosphodiesterase / nucleotide pyrophosphatase Alk_phosphatase PF00245.20 EMD68728.1 - 0.0025 16.8 0.0 0.0045 16.0 0.0 1.4 1 0 0 1 1 1 1 Alkaline phosphatase PglZ PF08665.12 EMD68728.1 - 0.03 14.4 0.0 0.066 13.3 0.0 1.5 1 0 0 1 1 1 0 PglZ domain Pkinase PF00069.25 EMD68729.1 - 1e-70 238.1 0.0 1.3e-70 237.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD68729.1 - 5e-27 94.8 0.0 6.3e-27 94.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMD68729.1 - 1.1e-06 28.3 0.0 1.6e-06 27.7 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EMD68729.1 - 0.00015 20.7 0.0 0.00027 19.9 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EMD68729.1 - 0.00069 19.0 0.0 0.0013 18.1 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EMD68729.1 - 0.00089 19.2 1.0 0.0013 18.8 0.1 1.8 2 0 0 2 2 2 1 Phosphotransferase enzyme family Peptidase_C15 PF01470.17 EMD68730.1 - 1.1e-08 35.5 0.0 0.0024 18.1 0.0 2.6 2 1 0 2 2 2 2 Pyroglutamyl peptidase FAD_binding_3 PF01494.19 EMD68731.1 - 3.4e-13 49.6 4.8 8.9e-11 41.6 0.6 3.0 2 1 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 EMD68731.1 - 1.5e-06 28.3 0.2 7.1e-06 26.2 0.2 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 EMD68731.1 - 2.1e-05 24.6 0.4 0.037 14.0 0.6 2.5 2 0 0 2 2 2 2 FAD-NAD(P)-binding SE PF08491.10 EMD68731.1 - 5.6e-05 22.3 0.0 0.00017 20.7 0.0 1.8 1 1 0 1 1 1 1 Squalene epoxidase DAO PF01266.24 EMD68731.1 - 0.0013 18.4 1.8 0.0013 18.4 1.8 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EMD68731.1 - 0.0051 16.1 0.5 0.0091 15.3 0.5 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 EMD68731.1 - 0.021 14.1 0.0 0.075 12.3 0.0 1.9 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase Pyr_redox PF00070.27 EMD68731.1 - 0.037 14.6 0.3 0.095 13.3 0.3 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Abhydrolase_1 PF00561.20 EMD68732.1 - 2.9e-14 53.3 0.0 4.6e-14 52.7 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EMD68732.1 - 9e-09 34.9 0.0 1.5e-08 34.2 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 EMD68732.1 - 0.0049 16.4 0.0 0.085 12.3 0.0 2.2 1 1 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S37 PF05576.11 EMD68732.1 - 0.015 14.0 0.0 0.025 13.3 0.0 1.3 1 0 0 1 1 1 0 PS-10 peptidase S37 Esterase PF00756.20 EMD68732.1 - 0.17 11.5 0.0 0.32 10.6 0.0 1.4 1 0 0 1 1 1 0 Putative esterase DUF4110 PF13422.6 EMD68733.1 - 1.3e-32 111.7 1.6 1.3e-32 111.7 1.6 2.7 3 0 0 3 3 3 1 Domain of unknown function (DUF4110) Kelch_4 PF13418.6 EMD68733.1 - 2.1e-28 98.1 10.7 1.4e-08 34.6 0.0 7.0 7 1 0 7 7 7 5 Galactose oxidase, central domain Kelch_5 PF13854.6 EMD68733.1 - 1.2e-22 79.4 0.8 7.4e-07 29.0 0.0 6.4 6 0 0 6 6 6 5 Kelch motif Kelch_6 PF13964.6 EMD68733.1 - 4.1e-21 74.5 5.9 1.9e-05 24.8 0.2 6.3 6 1 0 6 6 6 3 Kelch motif Kelch_3 PF13415.6 EMD68733.1 - 1.4e-19 69.9 13.4 5.4e-06 26.6 0.0 7.0 7 0 0 7 7 7 4 Galactose oxidase, central domain Kelch_1 PF01344.25 EMD68733.1 - 2.4e-15 55.8 1.5 0.00027 20.4 0.1 5.5 5 1 0 5 5 5 4 Kelch motif Kelch_2 PF07646.15 EMD68733.1 - 1.2e-13 50.4 4.9 0.019 14.9 0.1 6.1 6 1 0 6 6 6 3 Kelch motif Tub_N PF16322.5 EMD68733.1 - 0.2 12.1 24.6 6.5 7.1 1.2 3.5 2 1 0 2 2 2 0 Tubby N-terminal HA2 PF04408.23 EMD68734.1 - 2.5e-18 66.3 0.0 2.5e-18 66.3 0.0 2.2 2 1 0 2 2 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EMD68734.1 - 1.5e-13 50.9 0.0 4.8e-13 49.3 0.0 1.9 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EMD68734.1 - 9.4e-12 45.3 0.0 2.3e-11 44.0 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 EMD68734.1 - 3.2e-07 30.7 0.1 1.2e-06 28.8 0.0 2.0 2 0 0 2 2 2 1 AAA domain DEAD PF00270.29 EMD68734.1 - 3.5e-07 30.2 0.0 7.6e-07 29.1 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_19 PF13245.6 EMD68734.1 - 0.00025 21.4 0.0 0.00061 20.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EMD68734.1 - 0.00098 18.9 0.3 0.002 17.9 0.0 1.6 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.27 EMD68734.1 - 0.0012 19.3 0.0 0.0036 17.8 0.0 1.9 1 0 0 1 1 1 1 ABC transporter T2SSE PF00437.20 EMD68734.1 - 0.0019 17.3 0.0 0.0032 16.6 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_29 PF13555.6 EMD68734.1 - 0.01 15.6 0.0 0.023 14.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.6 EMD68734.1 - 0.025 14.9 0.3 0.34 11.3 0.0 2.6 2 1 0 2 2 2 0 AAA ATPase domain RsgA_GTPase PF03193.16 EMD68734.1 - 0.04 13.8 0.1 0.15 11.9 0.0 1.9 2 0 0 2 2 2 0 RsgA GTPase ATPase_2 PF01637.18 EMD68734.1 - 0.049 13.5 0.0 0.11 12.3 0.0 1.6 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea DAP3 PF10236.9 EMD68734.1 - 0.06 12.5 0.0 0.13 11.4 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 ATPase PF06745.13 EMD68734.1 - 0.12 11.7 0.3 0.81 9.0 0.0 2.3 3 0 0 3 3 3 0 KaiC Peptidase_M3 PF01432.20 EMD68735.1 - 7.9e-124 414.4 0.0 1e-123 414.0 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M3 Peptidase_M91 PF14891.6 EMD68735.1 - 0.067 13.5 0.1 0.16 12.2 0.1 1.6 1 0 0 1 1 1 0 Effector protein Peptidase_M50B PF13398.6 EMD68735.1 - 0.27 10.9 0.2 0.43 10.2 0.2 1.2 1 0 0 1 1 1 0 Peptidase M50B-like Peptidase_M2 PF01401.18 EMD68735.1 - 0.69 8.5 4.1 5.3 5.6 0.1 2.5 2 1 1 3 3 3 0 Angiotensin-converting enzyme ApoO PF09769.9 EMD68736.1 - 6.9e-38 129.5 0.6 1.2e-36 125.6 0.2 2.4 3 0 0 3 3 3 1 Apolipoprotein O Methyltransf_23 PF13489.6 EMD68737.1 - 5.7e-22 78.3 0.0 9.2e-22 77.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMD68737.1 - 3e-09 36.9 0.0 8.9e-09 35.3 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMD68737.1 - 9.3e-09 35.9 0.0 1.8e-08 35.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMD68737.1 - 1.1e-06 29.2 0.0 4e-06 27.5 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.19 EMD68737.1 - 2.9e-05 24.3 0.0 4.6e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase CMAS PF02353.20 EMD68737.1 - 8.9e-05 21.9 0.0 0.00014 21.2 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_4 PF02390.17 EMD68737.1 - 0.00026 20.5 0.0 0.00042 19.8 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_2 PF00891.18 EMD68737.1 - 0.0011 18.3 0.0 0.0019 17.6 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_11 PF08241.12 EMD68737.1 - 0.0024 18.5 0.0 0.0063 17.1 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.11 EMD68737.1 - 0.0066 15.4 0.0 0.11 11.4 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF1698) MTS PF05175.14 EMD68737.1 - 0.0094 15.5 0.0 0.016 14.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Ubie_methyltran PF01209.18 EMD68737.1 - 0.016 14.6 0.0 0.048 13.0 0.0 1.8 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family PCMT PF01135.19 EMD68737.1 - 0.13 12.0 0.0 0.3 10.8 0.0 1.6 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_15 PF09445.10 EMD68737.1 - 0.15 11.6 0.0 0.24 10.9 0.0 1.3 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase Gpi1 PF05024.15 EMD68738.1 - 5.7e-78 261.3 8.4 8.8e-78 260.7 8.4 1.3 1 0 0 1 1 1 1 N-acetylglucosaminyl transferase component (Gpi1) zf-CCCH_4 PF18044.1 EMD68740.1 - 1.6e-05 24.6 2.3 3.3e-05 23.6 2.3 1.5 1 0 0 1 1 1 1 CCCH-type zinc finger zf_CCCH_4 PF18345.1 EMD68740.1 - 0.00011 22.1 5.0 0.0002 21.3 5.0 1.5 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH PF00642.24 EMD68740.1 - 0.00029 20.7 2.2 0.00047 20.0 2.2 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Nucleoporin_FG PF13634.6 EMD68740.1 - 0.00053 20.8 159.3 1.7 9.5 24.5 7.3 2 1 2 4 4 4 1 Nucleoporin FG repeat region ANAPC1 PF12859.7 EMD68741.1 - 2e-32 112.5 2.0 2e-32 112.5 2.0 3.6 4 0 0 4 4 4 1 Anaphase-promoting complex subunit 1 PC_rep PF01851.22 EMD68741.1 - 5.2 7.7 5.1 86 3.9 0.1 4.1 4 0 0 4 4 4 0 Proteasome/cyclosome repeat GTP_EFTU PF00009.27 EMD68743.1 - 1.8e-09 37.5 0.0 7e-09 35.5 0.0 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MeaB PF03308.16 EMD68743.1 - 0.0092 15.0 1.0 0.64 9.0 0.1 3.0 3 0 0 3 3 3 1 Methylmalonyl Co-A mutase-associated GTPase MeaB ATP_bind_1 PF03029.17 EMD68743.1 - 0.05 13.4 1.1 1.4 8.7 0.0 2.2 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein T2SSE PF00437.20 EMD68743.1 - 0.074 12.1 0.0 0.13 11.3 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein DisA_N PF02457.16 EMD68744.1 - 0.088 12.4 0.0 0.11 12.1 0.0 1.1 1 0 0 1 1 1 0 DisA bacterial checkpoint controller nucleotide-binding zf-C2H2 PF00096.26 EMD68745.1 - 0.0036 17.7 4.0 0.42 11.2 0.4 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMD68745.1 - 0.011 16.5 2.6 4.4 8.4 0.2 3.0 2 0 0 2 2 2 0 C2H2-type zinc finger Cys_Met_Meta_PP PF01053.20 EMD68747.1 - 7.3e-33 113.6 0.0 9.9e-33 113.2 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 EMD68747.1 - 0.0096 15.1 0.0 0.033 13.4 0.0 1.7 2 0 0 2 2 2 1 Aminotransferase class I and II DUF1640 PF07798.11 EMD68748.1 - 4.6e-05 23.6 6.4 0.049 13.7 0.1 2.4 1 1 1 2 2 2 2 Protein of unknown function (DUF1640) DUF1633 PF07794.11 EMD68748.1 - 0.0024 16.2 1.2 0.0032 15.7 1.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1633) SlyX PF04102.12 EMD68748.1 - 0.014 16.0 12.2 0.06 14.0 3.7 3.8 2 2 1 3 3 3 0 SlyX NPV_P10 PF05531.12 EMD68748.1 - 0.063 13.7 7.6 0.13 12.8 0.0 3.7 1 1 2 3 3 3 0 Nucleopolyhedrovirus P10 protein TRAF_BIRC3_bd PF16673.5 EMD68748.1 - 0.065 13.0 3.5 2 8.3 0.1 3.3 3 0 0 3 3 3 0 TNF receptor-associated factor BIRC3 binding domain DUF4559 PF15112.6 EMD68748.1 - 0.078 12.6 5.5 0.037 13.7 3.4 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4559) ABC_tran_CTD PF16326.5 EMD68748.1 - 0.16 12.2 7.0 1.7 8.9 0.5 3.4 2 1 0 3 3 3 0 ABC transporter C-terminal domain DUF677 PF05055.12 EMD68748.1 - 0.19 10.6 3.7 0.11 11.4 0.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF677) YlqD PF11068.8 EMD68748.1 - 1.4 9.3 10.4 0.059 13.7 2.0 2.7 2 1 1 3 3 3 0 YlqD protein Sec34 PF04136.15 EMD68748.1 - 2 8.3 7.2 0.2 11.6 1.4 2.2 2 1 0 2 2 2 0 Sec34-like family TMF_DNA_bd PF12329.8 EMD68748.1 - 2.6 8.1 15.2 0.23 11.5 3.3 3.5 3 2 0 3 3 3 0 TATA element modulatory factor 1 DNA binding DUF1664 PF07889.12 EMD68748.1 - 2.7 8.1 4.8 40 4.3 0.1 2.7 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) DnaG_DnaB_bind PF08278.11 EMD68748.1 - 4.9 7.8 18.9 0.42 11.2 6.2 2.5 2 1 1 3 3 3 0 DNA primase DnaG DnaB-binding PCMT PF01135.19 EMD68749.1 - 1.5e-68 230.6 0.0 1.8e-68 230.5 0.0 1.0 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_25 PF13649.6 EMD68749.1 - 5.3e-08 33.5 0.0 1.3e-07 32.2 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMD68749.1 - 4.6e-07 29.7 0.0 6.9e-07 29.2 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EMD68749.1 - 0.00015 21.2 0.0 0.00022 20.6 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_32 PF13679.6 EMD68749.1 - 0.00015 21.8 0.0 0.00023 21.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMD68749.1 - 0.00015 22.3 0.0 0.00027 21.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EMD68749.1 - 0.00018 21.4 0.0 0.00024 21.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EMD68749.1 - 0.00084 18.9 0.0 0.0013 18.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain MetW PF07021.12 EMD68749.1 - 0.0017 18.0 0.0 0.0036 16.9 0.0 1.5 2 0 0 2 2 2 1 Methionine biosynthesis protein MetW GCD14 PF08704.10 EMD68749.1 - 0.0021 17.8 0.0 0.0028 17.4 0.0 1.2 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit PrmA PF06325.13 EMD68749.1 - 0.0036 16.7 0.1 0.006 16.0 0.1 1.4 1 1 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Fibrillarin PF01269.17 EMD68749.1 - 0.019 14.1 0.0 0.03 13.4 0.0 1.2 1 0 0 1 1 1 0 Fibrillarin Methyltransf_12 PF08242.12 EMD68749.1 - 0.025 15.3 0.0 0.051 14.3 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain FtsJ PF01728.19 EMD68749.1 - 0.033 14.3 0.0 0.055 13.6 0.0 1.5 1 1 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_18 PF12847.7 EMD68749.1 - 0.07 13.1 0.0 0.12 12.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_24 PF13578.6 EMD68749.1 - 0.072 14.1 0.0 0.18 12.8 0.0 1.7 1 1 1 2 2 2 0 Methyltransferase domain RrnaAD PF00398.20 EMD68749.1 - 0.087 11.9 0.0 0.12 11.4 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Nrap_D4 PF17405.2 EMD68750.1 - 2.1e-64 216.8 0.0 4e-64 215.9 0.0 1.5 1 0 0 1 1 1 1 Nrap protein nucleotidyltransferase domain 4 Nrap_D5 PF17406.2 EMD68750.1 - 6.4e-58 195.1 3.3 6.8e-57 191.8 1.0 2.9 2 1 0 2 2 2 1 Nrap protein PAP/OAS1-like domain 5 Nrap PF03813.14 EMD68750.1 - 8.8e-49 165.4 0.1 2.1e-48 164.2 0.1 1.7 1 0 0 1 1 1 1 Nrap protein domain 1 Nrap_D2 PF17403.2 EMD68750.1 - 1.5e-48 164.4 0.1 6.3e-48 162.4 0.1 2.1 2 0 0 2 2 2 1 Nrap protein PAP/OAS-like domain Nrap_D3 PF17404.2 EMD68750.1 - 1.8e-46 158.1 0.3 1.1e-45 155.6 0.0 2.2 2 0 0 2 2 2 1 Nrap protein domain 3 Nrap_D6 PF17407.2 EMD68750.1 - 4.3e-30 104.7 0.0 1e-29 103.4 0.0 1.7 1 0 0 1 1 1 1 Nrap protein domain 6 SDA1 PF05285.12 EMD68750.1 - 0.23 10.9 16.6 0.46 9.9 16.6 1.4 1 0 0 1 1 1 0 SDA1 Lin-8 PF03353.15 EMD68750.1 - 1.1 8.7 6.2 2.2 7.7 6.2 1.4 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist COesterase PF00135.28 EMD68751.1 - 1.2e-43 149.8 1.3 2.9e-41 141.9 0.0 2.0 1 1 1 2 2 2 2 Carboxylesterase family Abhydrolase_3 PF07859.13 EMD68751.1 - 8.3e-07 29.1 0.1 0.011 15.6 0.1 2.6 3 0 0 3 3 3 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EMD68751.1 - 0.0043 16.5 0.0 0.0072 15.8 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family HpaP PF09483.10 EMD68751.1 - 0.16 12.3 0.0 0.29 11.4 0.0 1.4 1 0 0 1 1 1 0 Type III secretion protein (HpaP) adh_short PF00106.25 EMD68752.1 - 1.8e-34 118.9 0.0 2.5e-34 118.5 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD68752.1 - 1.5e-27 96.6 0.0 2.6e-27 95.9 0.0 1.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD68752.1 - 0.00075 19.4 0.1 0.063 13.2 0.1 2.2 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 EMD68752.1 - 0.024 14.1 0.0 0.047 13.1 0.0 1.4 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family PAS_10 PF13596.6 EMD68752.1 - 0.092 13.4 0.0 0.17 12.5 0.0 1.3 1 0 0 1 1 1 0 PAS domain p450 PF00067.22 EMD68753.1 - 2.3e-69 234.3 0.0 2.8e-69 234.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Abhydrolase_1 PF00561.20 EMD68754.1 - 8.8e-24 84.5 0.0 8.2e-18 65.0 0.0 2.0 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EMD68754.1 - 2.4e-10 41.4 0.9 3.3e-10 41.0 0.9 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EMD68754.1 - 5.6e-09 35.6 0.0 3.7e-08 33.0 0.0 2.0 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_4 PF08386.10 EMD68754.1 - 0.0086 16.2 0.0 0.016 15.3 0.0 1.4 1 0 0 1 1 1 1 TAP-like protein Mito_carr PF00153.27 EMD68755.1 - 2.7e-64 213.1 0.0 1.3e-20 73.1 0.0 4.0 4 0 0 4 4 4 4 Mitochondrial carrier protein Serine_protease PF18405.1 EMD68755.1 - 0.0026 17.0 1.3 0.013 14.7 0.0 2.2 3 0 0 3 3 3 1 Gammaproteobacterial serine protease F-box-like PF12937.7 EMD68756.1 - 3.1e-08 33.4 0.2 6.4e-08 32.4 0.2 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EMD68756.1 - 0.00018 21.3 0.4 0.00036 20.3 0.4 1.5 1 0 0 1 1 1 1 F-box domain TPR_2 PF07719.17 EMD68756.1 - 0.0021 18.0 0.2 2.1 8.7 0.1 2.8 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 EMD68756.1 - 0.0022 17.7 0.1 0.44 10.5 0.2 2.7 1 1 1 2 2 2 2 Tetratricopeptide repeat MIT PF04212.18 EMD68756.1 - 0.0053 16.8 0.1 0.011 15.8 0.1 1.4 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain TPR_11 PF13414.6 EMD68756.1 - 0.027 14.1 0.1 1.5 8.6 0.0 2.5 1 1 1 2 2 2 0 TPR repeat Cpn60_TCP1 PF00118.24 EMD68757.1 - 1.3e-152 508.9 5.9 1.5e-152 508.7 5.9 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family F-box PF00646.33 EMD68758.1 - 0.1 12.5 3.7 0.65 9.9 3.7 2.2 1 1 0 1 1 1 0 F-box domain MFS_1 PF07690.16 EMD68759.1 - 1.2e-22 80.3 82.9 1.3e-20 73.7 50.7 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily OmdA PF13376.6 EMD68761.1 - 3.2e-10 39.9 0.0 5.7e-10 39.0 0.0 1.5 1 0 0 1 1 1 1 Bacteriocin-protection, YdeI or OmpD-Associated ELYS PF13934.6 EMD68762.1 - 1.4e-59 201.8 0.2 1.6e-59 201.5 0.2 1.1 1 0 0 1 1 1 1 Nuclear pore complex assembly Fungal_trans PF04082.18 EMD68763.1 - 3.2e-10 39.5 0.4 4.8e-10 38.9 0.4 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD68763.1 - 7e-10 38.9 7.3 1.3e-09 38.0 7.3 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Chlam_OMP3 PF03503.13 EMD68763.1 - 0.19 12.1 2.9 0.4 11.0 2.9 1.5 1 0 0 1 1 1 0 Chlamydia cysteine-rich outer membrane protein 3 MFS_1 PF07690.16 EMD68764.1 - 2.5e-35 122.0 39.7 2.5e-35 122.0 39.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EMD68764.1 - 4.6e-15 55.4 12.3 4.6e-15 55.4 12.3 2.4 1 1 1 2 2 2 1 Sugar (and other) transporter Ytp1 PF10355.9 EMD68765.1 - 6.3e-117 389.7 11.9 6.3e-117 389.7 11.9 1.5 2 0 0 2 2 2 1 Protein of unknown function (Ytp1) DUF2427 PF10348.9 EMD68765.1 - 1.5e-24 85.8 8.5 1.5e-24 85.8 8.5 2.8 3 0 0 3 3 3 1 Domain of unknown function (DUF2427) DUF3357 PF11837.8 EMD68765.1 - 0.11 13.0 0.1 2.5 8.6 0.0 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3357) DASH_Dam1 PF08653.10 EMD68766.1 - 6.8e-27 93.0 1.5 9.3e-27 92.6 1.5 1.2 1 0 0 1 1 1 1 DASH complex subunit Dam1 Hepatitis_core PF00906.20 EMD68766.1 - 0.12 11.9 0.1 0.12 11.9 0.1 2.3 2 0 0 2 2 2 0 Hepatitis core antigen CCDC24 PF15669.5 EMD68766.1 - 0.81 9.5 2.7 1.4 8.7 2.7 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 24 family CRAL_TRIO PF00650.20 EMD68767.1 - 4.6e-43 146.7 0.0 8.9e-43 145.8 0.0 1.5 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EMD68767.1 - 6.2e-16 58.3 0.1 1.8e-15 56.8 0.1 1.9 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 EMD68767.1 - 4.5e-07 30.1 0.0 1.2e-06 28.7 0.0 1.7 2 0 0 2 2 2 1 Divergent CRAL/TRIO domain Ribosomal_S2 PF00318.20 EMD68768.1 - 1.9e-66 223.4 0.2 2.9e-65 219.5 0.2 2.1 1 1 0 1 1 1 1 Ribosomal protein S2 DsbC PF11412.8 EMD68768.1 - 0.059 13.4 0.0 1.1 9.3 0.0 2.2 2 0 0 2 2 2 0 Disulphide bond corrector protein DsbC PAS_9 PF13426.7 EMD68769.1 - 1.1e-26 93.1 0.0 3.1e-16 59.5 0.0 3.7 3 0 0 3 3 3 3 PAS domain PAS_3 PF08447.12 EMD68769.1 - 2.8e-19 69.2 0.0 5.7e-11 42.6 0.0 4.1 4 0 0 4 4 4 3 PAS fold GATA PF00320.27 EMD68769.1 - 3.3e-15 55.4 8.3 6.7e-15 54.4 8.3 1.6 1 0 0 1 1 1 1 GATA zinc finger PAS PF00989.25 EMD68769.1 - 1.6e-13 50.7 0.0 8.5e-06 25.8 0.0 4.3 4 1 0 4 4 4 3 PAS fold PAS_11 PF14598.6 EMD68769.1 - 1.5e-06 28.3 0.0 0.0044 17.1 0.0 2.7 2 0 0 2 2 2 2 PAS domain PAS_4 PF08448.10 EMD68769.1 - 8.2e-06 26.0 0.0 0.052 13.8 0.0 3.5 3 0 0 3 3 3 2 PAS fold PAS_2 PF08446.11 EMD68769.1 - 0.0036 17.9 0.0 0.33 11.6 0.0 3.3 3 0 0 3 3 3 1 PAS fold Cytochrom_c3_2 PF14537.6 EMD68769.1 - 0.46 11.0 3.0 1.2 9.7 3.0 1.7 1 0 0 1 1 1 0 Cytochrome c3 Ras PF00071.22 EMD68770.1 - 1.6e-40 138.4 0.0 2e-40 138.1 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMD68770.1 - 1.7e-12 47.6 0.0 2.8e-12 46.9 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMD68770.1 - 5.4e-05 22.7 0.0 6.6e-05 22.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EMD68770.1 - 0.0012 18.9 0.0 0.002 18.2 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EMD68770.1 - 0.0046 16.5 0.0 0.092 12.3 0.0 2.2 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain NB-ARC PF00931.22 EMD68770.1 - 0.049 12.8 0.0 0.11 11.6 0.0 1.6 2 0 0 2 2 2 0 NB-ARC domain Mito_carr PF00153.27 EMD68771.1 - 1.9e-57 191.2 4.9 2.7e-21 75.3 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein FAM25 PF15825.5 EMD68773.1 - 0.0062 16.8 0.6 0.011 16.0 0.6 1.5 1 0 0 1 1 1 1 FAM25 family HisG_C PF08029.11 EMD68773.1 - 0.036 14.2 0.3 4 7.7 0.1 2.2 2 0 0 2 2 2 0 HisG, C-terminal domain RVT_1 PF00078.27 EMD68774.1 - 0.00033 20.3 0.1 0.00033 20.3 0.1 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) SGL PF08450.12 EMD68776.1 - 0.064 12.8 0.1 0.34 10.4 0.0 2.1 1 1 1 2 2 2 0 SMP-30/Gluconolactonase/LRE-like region Glyco_transf_90 PF05686.12 EMD68777.1 - 9e-39 133.5 2.1 1.1e-38 133.2 2.1 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 90 Glyco_trans_1_2 PF13524.6 EMD68777.1 - 0.015 15.7 0.1 0.028 14.8 0.1 1.5 1 0 0 1 1 1 0 Glycosyl transferases group 1 DnaJ PF00226.31 EMD68778.1 - 3e-22 78.5 0.7 3e-22 78.5 0.7 2.4 2 0 0 2 2 2 1 DnaJ domain zf-C2H2_jaz PF12171.8 EMD68778.1 - 3.4e-11 43.1 13.6 2.5e-10 40.4 7.1 2.5 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EMD68778.1 - 8e-11 42.0 9.4 3.5e-08 33.6 2.7 2.8 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 EMD68778.1 - 1.1e-05 25.7 8.3 0.0027 18.0 2.9 2.4 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 EMD68778.1 - 1.5e-05 25.4 5.0 0.05 14.5 0.6 2.5 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2HE PF16278.5 EMD68778.1 - 0.00036 20.9 2.6 1.4 9.4 0.3 3.5 3 0 0 3 3 3 2 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2 PF00096.26 EMD68778.1 - 0.0009 19.6 7.3 0.16 12.5 0.7 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-LYAR PF08790.11 EMD68778.1 - 0.1 12.6 0.3 0.1 12.6 0.3 1.9 2 0 0 2 2 2 0 LYAR-type C2HC zinc finger Herpes_LMP1 PF05297.11 EMD68778.1 - 0.31 10.2 9.0 0.44 9.7 9.0 1.2 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) zf-C2H2_6 PF13912.6 EMD68778.1 - 0.41 10.7 8.3 2.5 8.2 0.8 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger SPX PF03105.19 EMD68779.1 - 2.6e-51 175.7 1.7 6.7e-51 174.4 1.7 1.7 1 1 0 1 1 1 1 SPX domain zf-C3HC4_4 PF15227.6 EMD68779.1 - 1.2e-06 28.5 13.1 1.8e-06 28.0 11.6 2.0 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.6 EMD68779.1 - 5.5e-06 26.1 9.5 1.1e-05 25.2 9.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMD68779.1 - 6.3e-06 26.0 12.3 1.7e-05 24.6 12.3 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EMD68779.1 - 6.8e-06 26.0 7.1 2e-05 24.5 7.1 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 EMD68779.1 - 7.3e-05 23.0 10.7 0.00019 21.7 10.7 1.7 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 EMD68779.1 - 7.8e-05 22.6 11.8 0.00049 20.0 12.1 2.2 1 1 1 2 2 2 1 zinc-RING finger domain TerY_C PF15616.6 EMD68779.1 - 0.00027 21.1 1.4 0.00049 20.2 1.4 1.4 1 0 0 1 1 1 1 TerY-C metal binding domain Prok-RING_4 PF14447.6 EMD68779.1 - 0.00089 19.1 10.8 0.005 16.7 11.0 2.0 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 EMD68779.1 - 0.0012 18.7 11.5 0.0012 18.7 11.5 1.8 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) TFIIA_gamma_N PF02268.16 EMD68779.1 - 0.16 12.1 0.0 0.35 10.9 0.0 1.6 1 0 0 1 1 1 0 Transcription initiation factor IIA, gamma subunit, helical domain DUF1660 PF07874.11 EMD68779.1 - 0.18 12.3 2.4 0.77 10.3 2.4 2.2 1 0 0 1 1 1 0 Prophage protein (DUF1660) Cep57_MT_bd PF06657.13 EMD68779.1 - 0.21 12.1 2.6 2.3 8.7 0.2 2.6 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 zf-ANAPC11 PF12861.7 EMD68779.1 - 0.75 9.9 6.9 2.2 8.4 6.9 1.8 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.6 EMD68779.1 - 6.5 6.6 17.0 2.9 7.7 11.9 2.9 3 1 1 4 4 4 0 RING/Ubox like zinc-binding domain DUF2370 PF10176.9 EMD68780.1 - 5.9e-88 294.3 0.0 9.4e-88 293.7 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2370) Cwf_Cwc_15 PF04889.12 EMD68780.1 - 0.21 11.3 5.3 0.32 10.7 5.3 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein BEN PF10523.9 EMD68781.1 - 0.19 12.0 0.3 0.73 10.1 0.0 2.0 2 0 0 2 2 2 0 BEN domain GRIM-19 PF06212.12 EMD68782.1 - 8.5e-24 84.0 0.2 3.4e-23 82.0 0.2 1.7 1 1 0 1 1 1 1 GRIM-19 protein tRNA_m1G_MT PF01746.21 EMD68783.1 - 1.4e-26 93.4 0.0 3e-20 72.8 0.0 2.3 2 0 0 2 2 2 2 tRNA (Guanine-1)-methyltransferase TLD PF07534.16 EMD68784.1 - 2.8e-26 92.4 0.0 6.9e-15 55.5 0.0 2.2 2 0 0 2 2 2 2 TLD zf-RING_2 PF13639.6 EMD68786.1 - 0.00027 21.2 3.1 0.00068 19.9 3.1 1.7 1 0 0 1 1 1 1 Ring finger domain PHD PF00628.29 EMD68786.1 - 0.0013 18.6 1.5 0.0024 17.7 1.5 1.5 1 0 0 1 1 1 1 PHD-finger Prok-RING_1 PF14446.6 EMD68786.1 - 0.0019 18.1 3.1 0.0029 17.5 2.5 1.6 1 1 0 1 1 1 1 Prokaryotic RING finger family 1 Zn_ribbon_17 PF17120.5 EMD68786.1 - 0.0034 17.0 0.8 0.006 16.2 0.8 1.4 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-RING_9 PF13901.6 EMD68786.1 - 0.0037 17.3 1.7 0.0051 16.8 1.7 1.2 1 0 0 1 1 1 1 Putative zinc-RING and/or ribbon C1_1 PF00130.22 EMD68786.1 - 0.011 15.6 3.2 0.018 14.9 2.6 1.7 1 1 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-C3HC4 PF00097.25 EMD68786.1 - 0.11 12.4 3.4 0.24 11.3 3.4 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EMD68786.1 - 0.16 12.0 2.7 0.33 11.0 2.7 1.5 1 0 0 1 1 1 0 RING-type zinc-finger zf-rbx1 PF12678.7 EMD68786.1 - 0.32 11.3 6.6 0.68 10.3 6.6 1.7 1 1 0 1 1 1 0 RING-H2 zinc finger domain RINGv PF12906.7 EMD68786.1 - 2.4 8.4 8.1 0.44 10.7 3.6 2.1 2 1 1 3 3 3 0 RING-variant domain FA_desaturase PF00487.24 EMD68787.1 - 6.4e-16 58.9 17.4 1.2e-15 58.0 17.4 1.4 1 0 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.28 EMD68787.1 - 1.2e-15 57.4 0.0 2.1e-15 56.6 0.0 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain PDCD2_C PF04194.13 EMD68788.1 - 7.8e-45 153.1 0.0 6e-44 150.2 0.0 2.2 2 0 0 2 2 2 1 Programmed cell death protein 2, C-terminal putative domain CSN8_PSD8_EIF3K PF10075.9 EMD68789.1 - 2.2e-38 131.5 0.0 3.6e-38 130.8 0.0 1.3 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family Peptidase_S41 PF03572.18 EMD68790.1 - 2e-06 27.5 0.0 5.1e-06 26.2 0.0 1.7 1 1 0 1 1 1 1 Peptidase family S41 SUI1 PF01253.22 EMD68791.1 - 2.9e-28 98.2 3.9 3.6e-28 97.9 3.2 1.5 2 0 0 2 2 2 1 Translation initiation factor SUI1 DNA_ligase_A_M PF01068.21 EMD68792.1 - 6.2e-52 176.2 0.2 6.2e-49 166.4 0.0 2.7 3 0 0 3 3 3 2 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 EMD68792.1 - 4.2e-36 124.9 0.1 7.6e-36 124.0 0.1 1.5 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.15 EMD68792.1 - 3.8e-19 69.1 0.2 2.8e-18 66.3 0.0 2.5 2 0 0 2 2 2 1 ATP dependent DNA ligase C terminal region RNA_ligase PF09414.10 EMD68792.1 - 7.3e-05 23.1 0.0 0.00013 22.3 0.0 1.4 1 0 0 1 1 1 1 RNA ligase DUF5427 PF10310.9 EMD68792.1 - 0.033 13.2 0.1 0.033 13.2 0.1 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5427) Med14 PF08638.11 EMD68793.1 - 1.6e-54 184.2 0.1 1.6e-54 184.2 0.1 2.3 2 0 0 2 2 2 1 Mediator complex subunit MED14 DDHD PF02862.17 EMD68793.1 - 0.44 10.7 7.9 0.98 9.5 7.9 1.6 1 0 0 1 1 1 0 DDHD domain Neur_chan_memb PF02932.16 EMD68793.1 - 4.4 7.3 10.8 8.3 6.4 10.8 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region TERB2 PF15101.6 EMD68793.1 - 7.4 6.6 17.5 16 5.4 17.5 1.6 1 0 0 1 1 1 0 Telomere-associated protein TERB2 DUF4407 PF14362.6 EMD68793.1 - 9.8 5.4 15.2 1.7 7.9 11.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) ATG22 PF11700.8 EMD68794.1 - 7.5e-199 661.3 8.9 8.9e-199 661.0 8.9 1.0 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like MFS_1 PF07690.16 EMD68794.1 - 2.7e-05 23.3 23.5 2.7e-05 23.3 23.5 3.2 2 1 1 3 3 3 3 Major Facilitator Superfamily Synaphin PF05835.12 EMD68794.1 - 0.35 11.1 2.0 0.6 10.4 2.0 1.3 1 0 0 1 1 1 0 Synaphin protein TBPIP PF07106.13 EMD68795.1 - 1.8e-17 63.0 0.2 3.4e-17 62.1 0.2 1.5 1 0 0 1 1 1 1 TBPIP/Hop2 winged helix domain Penicillinase_R PF03965.16 EMD68795.1 - 0.0022 18.4 0.4 0.0048 17.2 0.0 1.8 2 1 0 2 2 2 1 Penicillinase repressor TMF_DNA_bd PF12329.8 EMD68795.1 - 0.004 17.1 0.2 0.011 15.7 0.2 1.8 1 0 0 1 1 1 1 TATA element modulatory factor 1 DNA binding MarR_2 PF12802.7 EMD68795.1 - 0.0076 16.1 0.0 0.024 14.5 0.0 1.9 1 0 0 1 1 1 1 MarR family Rrf2 PF02082.20 EMD68795.1 - 0.011 16.0 1.3 0.59 10.5 0.1 2.3 1 1 1 2 2 2 0 Transcriptional regulator CtsR_C PF17727.1 EMD68795.1 - 0.012 15.7 0.4 0.045 13.9 0.0 2.2 3 0 0 3 3 3 0 CtsR C-terminal dimerization domain DUF3811 PF11656.8 EMD68795.1 - 0.032 14.6 2.7 0.06 13.7 0.9 2.2 2 0 0 2 2 2 0 YjbD family (DUF3811) Lzipper-MIP1 PF14389.6 EMD68795.1 - 0.038 14.3 0.9 0.11 12.8 0.9 1.8 1 1 0 1 1 1 0 Leucine-zipper of ternary complex factor MIP1 Retrotran_gag_2 PF14223.6 EMD68795.1 - 0.094 12.4 1.2 0.38 10.4 0.1 2.2 2 1 0 2 2 2 0 gag-polypeptide of LTR copia-type DivIC PF04977.15 EMD68795.1 - 0.21 11.4 2.9 0.55 10.0 0.1 2.7 2 1 1 3 3 3 0 Septum formation initiator DUF4140 PF13600.6 EMD68795.1 - 0.8 10.2 5.0 0.76 10.3 0.6 2.6 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) TPR_MLP1_2 PF07926.12 EMD68795.1 - 3.9 7.5 9.8 0.3 11.1 3.0 2.6 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein AAA PF00004.29 EMD68796.1 - 1.1e-38 132.7 0.0 2.2e-38 131.7 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 EMD68796.1 - 5.5e-10 39.1 0.1 7.5e-07 29.0 0.0 3.6 3 0 0 3 3 3 1 Vps4 C terminal oligomerisation domain AAA_lid_3 PF17862.1 EMD68796.1 - 1.2e-09 37.8 0.0 2.5e-09 36.8 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_22 PF13401.6 EMD68796.1 - 1.3e-05 25.5 0.3 0.00093 19.5 0.3 2.8 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.12 EMD68796.1 - 2.9e-05 23.9 0.0 6.3e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 EMD68796.1 - 0.00026 21.2 0.0 0.00055 20.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 EMD68796.1 - 0.00057 19.9 0.0 0.0019 18.2 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) TIP49 PF06068.13 EMD68796.1 - 0.00071 18.9 0.1 0.0014 17.9 0.1 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain IstB_IS21 PF01695.17 EMD68796.1 - 0.0019 18.0 0.0 0.0043 16.8 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_16 PF13191.6 EMD68796.1 - 0.0025 18.2 0.3 0.0025 18.2 0.3 3.6 4 1 0 4 4 4 1 AAA ATPase domain Mg_chelatase PF01078.21 EMD68796.1 - 0.0044 16.4 0.1 0.0098 15.3 0.1 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI DUF815 PF05673.13 EMD68796.1 - 0.0052 16.0 0.0 0.01 15.1 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_18 PF13238.6 EMD68796.1 - 0.012 16.1 0.0 0.039 14.5 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EMD68796.1 - 0.013 15.7 0.2 0.044 13.9 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.6 EMD68796.1 - 0.021 14.9 0.0 0.045 13.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 EMD68796.1 - 0.027 14.1 0.0 0.17 11.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 EMD68796.1 - 0.045 13.3 0.0 0.26 10.8 0.0 2.0 2 0 0 2 2 2 0 P-loop containing dynein motor region NACHT PF05729.12 EMD68796.1 - 0.094 12.6 0.0 0.26 11.2 0.0 1.8 1 0 0 1 1 1 0 NACHT domain AAA_24 PF13479.6 EMD68796.1 - 0.1 12.3 0.0 0.23 11.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain MIT PF04212.18 EMD68796.1 - 0.14 12.3 0.0 0.41 10.8 0.0 1.9 1 0 0 1 1 1 0 MIT (microtubule interacting and transport) domain Sigma54_activat PF00158.26 EMD68796.1 - 0.17 11.5 0.0 0.4 10.4 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_11 PF13086.6 EMD68796.1 - 0.19 11.5 3.9 0.86 9.3 0.0 3.1 3 2 1 4 4 4 0 AAA domain TBPIP PF07106.13 EMD68796.1 - 0.2 11.6 0.0 0.69 9.9 0.0 1.8 2 0 0 2 2 1 0 TBPIP/Hop2 winged helix domain AAA_28 PF13521.6 EMD68796.1 - 0.59 10.4 2.8 0.92 9.7 0.1 2.7 3 1 1 4 4 3 0 AAA domain Mito_carr PF00153.27 EMD68798.1 - 1.2e-62 207.8 1.2 9.4e-22 76.8 0.1 3.4 3 0 0 3 3 3 3 Mitochondrial carrier protein tRNA-synt_2 PF00152.20 EMD68798.1 - 1.1e-61 208.6 0.0 1.7e-61 208.0 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) DUF2263 PF10021.9 EMD68799.1 - 3.7e-14 53.3 0.0 6e-14 52.6 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2263) COX6B PF02297.17 EMD68800.1 - 1.2e-23 83.1 6.2 1.5e-23 82.8 6.2 1.1 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb Pet191_N PF10203.9 EMD68800.1 - 0.091 13.1 2.7 0.78 10.1 0.2 2.1 1 1 1 2 2 2 0 Cytochrome c oxidase assembly protein PET191 SYS1 PF09801.9 EMD68801.1 - 6.9e-60 201.4 10.8 7.8e-60 201.2 10.8 1.0 1 0 0 1 1 1 1 Integral membrane protein S linking to the trans Golgi network Saf_2TM PF18303.1 EMD68801.1 - 0.48 10.0 3.2 0.83 9.2 3.2 1.4 1 0 0 1 1 1 0 SAVED-fused 2TM effector domain DUF4407 PF14362.6 EMD68801.1 - 2.8 7.2 4.4 3.9 6.8 4.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TPR_19 PF14559.6 EMD68802.1 - 1.3e-06 28.8 1.4 0.0031 18.0 0.0 4.9 3 1 3 6 6 6 1 Tetratricopeptide repeat TPR_1 PF00515.28 EMD68802.1 - 1.6e-06 27.6 0.4 0.0038 17.0 0.7 5.0 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_8 PF13181.6 EMD68802.1 - 3.3e-05 23.7 1.0 0.19 12.0 0.5 4.9 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_11 PF13414.6 EMD68802.1 - 4.4e-05 23.1 3.5 0.044 13.5 0.0 3.8 3 1 0 3 3 3 2 TPR repeat TPR_7 PF13176.6 EMD68802.1 - 0.00026 20.8 1.6 17 5.7 0.0 7.1 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_2 PF07719.17 EMD68802.1 - 0.00036 20.4 9.4 0.012 15.7 0.7 6.1 9 0 0 9 9 9 1 Tetratricopeptide repeat TPR_16 PF13432.6 EMD68802.1 - 0.00056 20.5 1.0 1.3 9.7 0.1 4.5 3 0 0 3 3 3 1 Tetratricopeptide repeat HTH_16 PF12645.7 EMD68802.1 - 0.0081 16.2 0.0 0.058 13.5 0.0 2.3 2 0 0 2 2 2 1 Helix-turn-helix domain TPR_14 PF13428.6 EMD68802.1 - 0.17 12.8 18.0 1.5 9.9 0.0 7.7 9 1 1 10 10 10 0 Tetratricopeptide repeat NACHT_N PF17100.5 EMD68803.1 - 5.6e-11 42.7 0.9 2.3e-10 40.7 0.9 2.0 1 1 0 1 1 1 1 N-terminal domain of NWD NACHT-NTPase NACHT PF05729.12 EMD68803.1 - 5.4e-10 39.4 0.0 1.5e-07 31.5 0.0 3.1 2 2 0 2 2 2 1 NACHT domain AAA_22 PF13401.6 EMD68803.1 - 5e-05 23.6 0.0 0.00038 20.7 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EMD68803.1 - 6e-05 23.5 0.0 0.0024 18.3 0.0 3.3 3 1 1 4 4 4 1 AAA ATPase domain KAP_NTPase PF07693.14 EMD68803.1 - 0.13 11.5 3.2 8.4 5.5 0.0 3.4 3 1 1 4 4 4 0 KAP family P-loop domain RNA_helicase PF00910.22 EMD68803.1 - 0.14 12.6 0.0 0.52 10.7 0.0 2.0 2 0 0 2 2 2 0 RNA helicase Cullin PF00888.22 EMD68804.1 - 1e-16 60.7 0.1 2.6e-16 59.4 0.0 1.6 2 0 0 2 2 2 1 Cullin family ANAPC2 PF08672.11 EMD68804.1 - 4.4e-14 52.7 0.2 2.3e-13 50.4 0.1 2.4 2 0 0 2 2 2 1 Anaphase promoting complex (APC) subunit 2 ATP_bind_2 PF03668.15 EMD68804.1 - 0.15 11.3 0.3 0.54 9.5 0.1 1.8 2 0 0 2 2 2 0 P-loop ATPase protein family F-box-like PF12937.7 EMD68805.1 - 0.9 9.5 5.9 0.31 11.0 1.6 2.5 2 0 0 2 2 2 0 F-box-like SMC_N PF02463.19 EMD68806.1 - 1.6e-27 96.4 0.0 2.8e-27 95.6 0.0 1.4 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EMD68806.1 - 2.5e-10 41.2 31.1 2.5e-10 41.2 31.1 5.8 3 2 0 3 3 3 1 AAA domain AAA_15 PF13175.6 EMD68806.1 - 1.3e-08 35.0 4.0 1.3e-08 35.0 4.0 3.2 2 2 0 3 3 3 1 AAA ATPase domain AAA_21 PF13304.6 EMD68806.1 - 1.1e-07 31.9 4.3 0.00016 21.6 0.1 3.4 3 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EMD68806.1 - 9.5e-05 22.1 0.0 0.00021 21.0 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.6 EMD68806.1 - 0.51 10.6 5.8 29 4.9 0.1 4.1 3 0 0 3 3 3 0 AAA domain GP41 PF00517.17 EMD68806.1 - 0.69 9.8 0.0 0.69 9.8 0.0 3.2 4 0 0 4 4 4 0 Retroviral envelope protein Sel1 PF08238.12 EMD68807.1 - 2e-19 69.6 25.3 4.4e-06 27.2 1.5 6.9 7 0 0 7 7 7 5 Sel1 repeat ASF1_hist_chap PF04729.13 EMD68808.1 - 8.2e-73 243.4 0.1 1.1e-72 243.0 0.1 1.2 1 0 0 1 1 1 1 ASF1 like histone chaperone Nop14 PF04147.12 EMD68808.1 - 1.9 6.6 21.1 2.4 6.2 21.1 1.0 1 0 0 1 1 1 0 Nop14-like family BUD22 PF09073.10 EMD68808.1 - 6.6 6.0 17.2 8.8 5.6 17.2 1.1 1 0 0 1 1 1 0 BUD22 Ribosomal_L11_N PF03946.14 EMD68809.1 - 6e-24 83.7 0.1 1.4e-23 82.5 0.1 1.6 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Fungal_trans PF04082.18 EMD68809.1 - 6.3e-14 51.7 0.0 9.8e-14 51.0 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Ribosomal_L11 PF00298.19 EMD68809.1 - 4.5e-12 46.3 0.2 8.8e-12 45.4 0.2 1.5 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain Zn_clus PF00172.18 EMD68809.1 - 2e-08 34.2 9.4 3.5e-08 33.4 9.4 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Plus-3 PF03126.18 EMD68809.1 - 0.0098 16.4 0.1 0.028 14.9 0.1 1.7 1 0 0 1 1 1 1 Plus-3 domain Glyco_transf_8 PF01501.20 EMD68810.1 - 0.08 12.5 0.2 0.67 9.4 0.0 2.1 2 0 0 2 2 2 0 Glycosyl transferase family 8 Glyco_hydro_20 PF00728.22 EMD68811.1 - 1.9e-93 313.7 0.2 2.4e-93 313.4 0.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.6 EMD68811.1 - 1.4e-21 77.6 0.0 2.9e-21 76.5 0.0 1.6 1 0 0 1 1 1 1 beta-acetyl hexosaminidase like Glyco_hydro_20b PF02838.15 EMD68811.1 - 0.00042 21.1 0.1 0.0024 18.6 0.1 2.3 2 1 0 2 2 2 1 Glycosyl hydrolase family 20, domain 2 HET PF06985.11 EMD68813.1 - 1.5e-23 83.8 0.0 2.7e-23 83.0 0.0 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) DOG1 PF14144.6 EMD68813.1 - 0.2 11.9 1.6 1.3 9.2 0.0 3.0 4 0 0 4 4 4 0 Seed dormancy control RMI1_N PF08585.12 EMD68814.1 - 6e-62 209.2 0.0 7.1e-62 209.0 0.0 1.0 1 0 0 1 1 1 1 RecQ mediated genome instability protein Vps51 PF08700.11 EMD68815.1 - 1.1e-32 111.9 0.0 2.3e-32 110.9 0.0 1.6 1 0 0 1 1 1 1 Vps51/Vps67 Dor1 PF04124.12 EMD68815.1 - 0.0022 16.7 0.2 0.0028 16.4 0.2 1.1 1 0 0 1 1 1 1 Dor1-like family COG5 PF10392.9 EMD68815.1 - 0.0023 18.1 0.2 0.0055 16.9 0.2 1.6 1 0 0 1 1 1 1 Golgi transport complex subunit 5 CTK3_C PF12350.8 EMD68815.1 - 0.046 13.9 3.9 0.11 12.6 3.9 1.6 1 0 0 1 1 1 0 CTD kinase subunit gamma CTK3 C-terminus DUF3456 PF11938.8 EMD68815.1 - 0.096 13.2 2.3 0.17 12.4 2.3 1.4 1 0 0 1 1 1 0 TLR4 regulator and MIR-interacting MSAP TPR_12 PF13424.6 EMD68816.1 - 1.6e-168 547.3 77.6 3.5e-21 75.3 1.0 8.9 1 1 10 11 11 11 11 Tetratricopeptide repeat TPR_10 PF13374.6 EMD68816.1 - 1.8e-123 399.6 30.7 1.9e-12 46.6 0.1 12.0 12 0 0 12 12 11 11 Tetratricopeptide repeat TPR_7 PF13176.6 EMD68816.1 - 2e-46 152.7 34.8 0.00052 19.8 0.2 12.0 11 0 0 11 11 11 10 Tetratricopeptide repeat TPR_1 PF00515.28 EMD68816.1 - 1.1e-39 132.6 37.1 0.00029 20.5 0.2 11.6 11 0 0 11 11 11 9 Tetratricopeptide repeat TPR_8 PF13181.6 EMD68816.1 - 5.6e-24 82.3 22.1 0.09 13.0 0.0 11.9 12 0 0 12 12 11 7 Tetratricopeptide repeat TPR_2 PF07719.17 EMD68816.1 - 2e-23 80.5 35.6 0.12 12.6 0.4 12.0 11 0 0 11 11 11 8 Tetratricopeptide repeat TPR_14 PF13428.6 EMD68816.1 - 7.5e-21 73.0 34.4 0.18 12.7 0.2 12.7 13 0 0 13 13 11 5 Tetratricopeptide repeat TPR_16 PF13432.6 EMD68816.1 - 1.5e-17 64.0 24.1 0.0016 19.1 0.7 9.9 6 3 4 10 10 10 6 Tetratricopeptide repeat TPR_4 PF07721.14 EMD68816.1 - 6.1e-17 60.5 0.9 2.4 9.0 0.0 9.9 10 0 0 10 10 8 1 Tetratricopeptide repeat TPR_MalT PF17874.1 EMD68816.1 - 6.1e-17 62.0 25.2 5.5e-09 35.8 3.7 4.5 2 1 5 7 7 7 6 MalT-like TPR region NB-ARC PF00931.22 EMD68816.1 - 2.6e-14 53.0 0.1 4.9e-14 52.1 0.1 1.4 1 0 0 1 1 1 1 NB-ARC domain DUF1925 PF09094.11 EMD68816.1 - 1.4e-13 50.9 9.2 10 6.5 0.1 9.7 8 1 1 9 9 9 0 Domain of unknown function (DUF1925) TPR_17 PF13431.6 EMD68816.1 - 3.4e-13 49.0 3.9 7.7 7.1 0.0 10.7 10 0 0 10 10 10 0 Tetratricopeptide repeat HET PF06985.11 EMD68816.1 - 7.3e-13 49.1 11.1 4.4e-11 43.3 1.2 3.9 2 1 1 3 3 3 2 Heterokaryon incompatibility protein (HET) ANAPC3 PF12895.7 EMD68816.1 - 1.8e-09 37.7 12.2 1.2 9.5 0.0 8.4 1 1 7 8 8 8 3 Anaphase-promoting complex, cyclosome, subunit 3 AAA_22 PF13401.6 EMD68816.1 - 4.6e-07 30.2 2.2 6.1e-07 29.8 0.1 2.3 2 1 1 3 3 1 1 AAA domain TPR_19 PF14559.6 EMD68816.1 - 5.2e-07 30.1 24.2 2 9.0 0.8 7.5 1 1 8 10 10 10 2 Tetratricopeptide repeat nec1 PF10379.9 EMD68816.1 - 2.4e-06 27.2 0.0 1.4 8.4 0.0 6.0 1 1 6 7 7 7 1 Virulence protein nec1 AAA_16 PF13191.6 EMD68816.1 - 6.3e-06 26.7 0.9 6.3e-06 26.7 0.9 2.7 2 1 0 2 2 1 1 AAA ATPase domain ATPase_2 PF01637.18 EMD68816.1 - 4.3e-05 23.6 0.0 0.00011 22.2 0.0 1.7 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea TniB PF05621.11 EMD68816.1 - 8.1e-05 22.1 0.0 0.0002 20.8 0.0 1.6 1 0 0 1 1 1 1 Bacterial TniB protein NACHT PF05729.12 EMD68816.1 - 0.0002 21.3 0.2 0.00047 20.1 0.2 1.6 1 0 0 1 1 1 1 NACHT domain SRP54 PF00448.22 EMD68816.1 - 0.0024 17.5 0.2 0.0047 16.6 0.2 1.5 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain AAA PF00004.29 EMD68816.1 - 0.0077 16.7 0.0 0.046 14.1 0.0 2.4 3 0 0 3 3 1 1 ATPase family associated with various cellular activities (AAA) TetR_C_34 PF17929.1 EMD68816.1 - 0.01 15.9 10.3 12 6.0 0.1 7.1 2 2 7 9 9 8 0 Tetracyclin repressor-like, C-terminal domain DnaB_C PF03796.15 EMD68816.1 - 0.021 14.2 0.1 0.063 12.6 0.1 1.8 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain IstB_IS21 PF01695.17 EMD68816.1 - 0.039 13.7 0.0 0.14 11.8 0.0 2.0 1 0 0 1 1 1 0 IstB-like ATP binding protein Peripla_BP_2 PF01497.18 EMD68816.1 - 0.1 12.1 0.2 7.9 6.0 0.0 2.8 2 0 0 2 2 2 0 Periplasmic binding protein KptA_kDCL PF18176.1 EMD68816.1 - 0.11 12.4 1.2 0.51 10.2 0.4 2.4 2 0 0 2 2 2 0 KptA in kinetoplastid DICER domain ISG65-75 PF11727.8 EMD68816.1 - 0.31 10.2 12.9 1.1 8.4 0.1 5.2 2 1 2 6 6 6 0 Invariant surface glycoprotein TPR_9 PF13371.6 EMD68816.1 - 0.34 11.1 15.0 19 5.5 0.4 7.4 7 2 3 10 10 9 0 Tetratricopeptide repeat TPR_11 PF13414.6 EMD68816.1 - 4.5 7.1 20.0 1.1e+02 2.5 0.0 8.9 9 0 0 9 9 9 0 TPR repeat Mpv17_PMP22 PF04117.12 EMD68818.1 - 3.1e-17 62.6 0.7 7.2e-17 61.4 0.7 1.7 1 0 0 1 1 1 1 Mpv17 / PMP22 family Pan_kinase PF03309.14 EMD68818.1 - 0.13 12.1 0.0 0.36 10.6 0.0 1.6 2 0 0 2 2 2 0 Type III pantothenate kinase Glyco_hydro_61 PF03443.14 EMD68819.1 - 5.4e-47 160.4 0.3 8.1e-47 159.8 0.3 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 CBM_1 PF00734.18 EMD68819.1 - 6.4e-13 48.4 11.0 1.8e-12 47.0 11.0 1.9 1 0 0 1 1 1 1 Fungal cellulose binding domain Glyco_hydro_12 PF01670.16 EMD68820.1 - 3.8e-57 193.7 10.9 4.7e-57 193.4 10.9 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 12 YdjM PF04307.14 EMD68822.1 - 0.058 12.7 0.1 0.058 12.7 0.1 1.1 1 0 0 1 1 1 0 LexA-binding, inner membrane-associated putative hydrolase Oxysterol_BP PF01237.18 EMD68823.1 - 5.7e-53 180.1 0.0 1.3e-50 172.3 0.0 2.1 1 1 0 1 1 1 1 Oxysterol-binding protein SCO1-SenC PF02630.14 EMD68823.1 - 0.079 12.9 0.0 13 5.7 0.0 2.4 2 0 0 2 2 2 0 SCO1/SenC U1snRNP70_N PF12220.8 EMD68823.1 - 0.86 10.3 4.0 7 7.4 0.5 2.7 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal Peptidase_C2 PF00648.21 EMD68824.1 - 2.8e-28 98.8 0.0 4.8e-28 98.0 0.0 1.3 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.22 EMD68824.1 - 6.4e-07 29.7 0.3 4.6e-05 23.7 0.0 3.4 3 1 0 3 3 3 1 Calpain large subunit, domain III MIT PF04212.18 EMD68824.1 - 0.00049 20.1 1.3 0.00089 19.3 1.3 1.4 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain Mito_carr PF00153.27 EMD68825.1 - 1.2e-53 179.0 1.0 4.4e-21 74.6 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF3147 PF11345.8 EMD68825.1 - 0.18 12.2 2.1 0.21 12.0 0.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3147) VirB8 PF04335.13 EMD68825.1 - 0.25 11.1 1.2 8 6.2 0.2 2.2 2 0 0 2 2 2 0 VirB8 protein Glyco_hydro_47 PF01532.20 EMD68827.1 - 2.3e-178 593.8 0.0 2.8e-178 593.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Bac_DnaA PF00308.18 EMD68828.1 - 0.35 10.7 4.2 0.69 9.7 4.2 1.4 1 0 0 1 1 1 0 Bacterial dnaA protein FHA PF00498.26 EMD68829.1 - 4.2e-14 52.6 0.0 8.3e-14 51.7 0.0 1.5 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 EMD68829.1 - 0.041 14.2 0.1 7.6 6.9 0.0 2.3 1 1 1 2 2 2 0 Inner membrane component of T3SS, cytoplasmic domain zf-RING_2 PF13639.6 EMD68830.1 - 2.2e-10 40.7 5.7 2.2e-10 40.7 5.7 1.9 2 0 0 2 2 2 1 Ring finger domain zf-rbx1 PF12678.7 EMD68830.1 - 4.6e-08 33.2 2.7 1.1e-07 32.0 2.7 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 EMD68830.1 - 9e-08 31.9 4.5 9.8e-08 31.7 2.7 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMD68830.1 - 4.2e-06 26.5 4.5 4.2e-06 26.5 4.5 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EMD68830.1 - 2.3e-05 24.2 7.5 2.8e-05 23.8 5.6 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EMD68830.1 - 8.4e-05 22.4 3.7 8.4e-05 22.4 3.7 2.0 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_11 PF17123.5 EMD68830.1 - 0.0019 17.9 4.8 0.011 15.5 1.9 2.4 2 0 0 2 2 2 1 RING-like zinc finger zf-ANAPC11 PF12861.7 EMD68830.1 - 0.0055 16.7 1.3 0.013 15.5 1.3 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.6 EMD68830.1 - 0.018 15.0 4.7 0.11 12.5 3.9 2.2 2 0 0 2 2 2 0 zinc-RING finger domain Zn_ribbon_17 PF17120.5 EMD68830.1 - 0.29 10.8 2.9 0.49 10.0 2.9 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type HAD_SAK_1 PF10307.9 EMD68831.1 - 1.3e-74 250.4 0.0 2.1e-74 249.8 0.0 1.3 1 0 0 1 1 1 1 HAD domain family 1 in Swiss Army Knife RNA repair proteins Glyoxalase PF00903.25 EMD68834.1 - 0.071 13.3 0.1 0.43 10.8 0.0 2.3 2 0 0 2 2 2 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily YtxH PF12732.7 EMD68834.1 - 0.14 12.7 0.7 0.56 10.8 0.7 2.1 1 0 0 1 1 1 0 YtxH-like protein EMG1 PF03587.14 EMD68835.1 - 3.5e-76 255.2 0.0 4.1e-76 255.0 0.0 1.0 1 0 0 1 1 1 1 EMG1/NEP1 methyltransferase OAD_gamma PF04277.13 EMD68836.1 - 0.12 13.0 0.6 0.17 12.5 0.6 1.2 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain NAD_binding_6 PF08030.12 EMD68837.1 - 5.3e-32 111.1 0.0 8.5e-32 110.4 0.0 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EMD68837.1 - 4.6e-20 71.7 0.1 1.2e-19 70.4 0.0 1.8 2 0 0 2 2 2 1 FAD-binding domain Ferric_reduct PF01794.19 EMD68837.1 - 2.5e-17 63.2 12.0 2.5e-17 63.2 12.0 2.4 1 1 1 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_6 PF00970.24 EMD68837.1 - 0.041 14.2 0.0 0.089 13.2 0.0 1.5 1 0 0 1 1 1 0 Oxidoreductase FAD-binding domain Lactamase_B PF00753.27 EMD68838.1 - 1.3e-05 25.3 0.1 0.00038 20.5 0.0 2.3 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EMD68838.1 - 0.00012 21.6 0.0 0.00068 19.2 0.0 2.2 3 0 0 3 3 3 1 Beta-lactamase superfamily domain HemY_N PF07219.13 EMD68839.1 - 0.23 11.7 2.5 0.27 11.5 2.5 1.2 1 0 0 1 1 1 0 HemY protein N-terminus zf-CCHC PF00098.23 EMD68839.1 - 0.28 11.3 3.2 0.46 10.6 3.2 1.3 1 0 0 1 1 1 0 Zinc knuckle Peptidase_C12 PF01088.21 EMD68840.1 - 6.2e-52 176.4 0.0 1e-51 175.7 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 FAM60A PF15396.6 EMD68840.1 - 1.6 8.7 6.3 1.8 8.5 0.0 2.6 3 0 0 3 3 3 0 Protein Family FAM60A NCE101 PF11654.8 EMD68841.1 - 0.16 11.7 0.1 0.61 9.8 0.0 2.0 2 0 0 2 2 2 0 Non-classical export protein 1 CRAL_TRIO PF00650.20 EMD68842.1 - 6.5e-24 84.5 0.0 9.5e-24 83.9 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EMD68842.1 - 2.9e-09 36.9 0.1 6.3e-09 35.9 0.1 1.6 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain Tape_meas_lam_C PF09718.10 EMD68842.1 - 0.21 11.8 0.9 0.4 10.8 0.9 1.4 1 0 0 1 1 1 0 Lambda phage tail tape-measure protein (Tape_meas_lam_C) YccV-like PF08755.11 EMD68843.1 - 8.4e-28 96.8 0.1 2e-27 95.6 0.1 1.7 1 0 0 1 1 1 1 Hemimethylated DNA-binding protein YccV like Transglut_core2 PF13369.6 EMD68843.1 - 1.7e-15 56.9 0.0 3.2e-15 56.0 0.0 1.4 1 0 0 1 1 1 1 Transglutaminase-like superfamily F-box-like PF12937.7 EMD68843.1 - 6e-09 35.7 0.1 1.2e-08 34.7 0.1 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EMD68843.1 - 4.3e-05 23.3 0.1 0.0001 22.0 0.1 1.7 1 0 0 1 1 1 1 F-box domain Elongin_A PF06881.11 EMD68843.1 - 0.0001 22.8 0.1 0.00023 21.6 0.1 1.6 1 0 0 1 1 1 1 RNA polymerase II transcription factor SIII (Elongin) subunit A F-box_4 PF15966.5 EMD68843.1 - 0.0067 16.3 0.0 0.015 15.2 0.0 1.5 1 0 0 1 1 1 1 F-box Sugar_tr PF00083.24 EMD68844.1 - 4.7e-123 411.4 22.6 5.4e-123 411.2 22.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD68844.1 - 5e-20 71.7 33.2 1.4e-13 50.5 15.2 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily TMEM132D_C PF15706.5 EMD68844.1 - 0.09 12.6 0.0 0.25 11.2 0.0 1.7 1 0 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term Linker_histone PF00538.19 EMD68845.1 - 3.7e-26 91.3 0.1 3.7e-26 91.3 0.1 2.1 2 0 0 2 2 2 1 linker histone H1 and H5 family TFIIF_alpha PF05793.12 EMD68845.1 - 8.2 4.9 41.0 11 4.5 41.0 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Ribonuclease_T2 PF00445.18 EMD68847.1 - 1.6e-41 142.6 0.8 1.6e-41 142.6 0.8 1.5 2 0 0 2 2 2 1 Ribonuclease T2 family SHMT PF00464.19 EMD68848.1 - 1.1e-204 679.5 0.0 1.3e-204 679.3 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Aminotran_1_2 PF00155.21 EMD68848.1 - 3.2e-06 26.5 0.0 7.7e-06 25.3 0.0 1.6 1 1 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 EMD68848.1 - 0.00084 18.7 0.0 0.002 17.4 0.0 1.7 1 1 0 1 1 1 1 Beta-eliminating lyase Fig1 PF12351.8 EMD68849.1 - 2.3e-59 200.5 4.0 2.3e-59 200.5 4.0 2.0 2 0 0 2 2 2 1 Ca2+ regulator and membrane fusion protein Fig1 SUR7 PF06687.12 EMD68849.1 - 1.8e-09 37.6 7.7 3.1e-09 36.8 7.7 1.4 1 1 0 1 1 1 1 SUR7/PalI family DUF898 PF05987.13 EMD68849.1 - 0.12 11.3 12.3 0.38 9.8 12.2 1.7 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF898) DUF751 PF05421.11 EMD68849.1 - 0.54 11.0 0.1 0.54 11.0 0.1 3.9 4 0 0 4 4 4 0 Protein of unknown function (DUF751) HSP9_HSP12 PF04119.12 EMD68850.1 - 4.6e-21 75.0 8.4 4.6e-21 75.0 8.4 1.4 2 0 0 2 2 2 1 Heat shock protein 9/12 DEAD PF00270.29 EMD68851.1 - 9.7e-22 77.6 0.0 1.4e-20 73.8 0.0 2.4 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EMD68851.1 - 2.6e-20 72.8 0.0 1.2e-17 64.3 0.0 2.7 2 0 0 2 2 2 2 Helicase conserved C-terminal domain RecQ_Zn_bind PF16124.5 EMD68851.1 - 7.6e-16 58.6 5.3 3e-15 56.7 5.3 2.2 1 0 0 1 1 1 1 RecQ zinc-binding RQC PF09382.10 EMD68851.1 - 1.3e-14 54.0 0.1 3.2e-14 52.7 0.1 1.7 1 0 0 1 1 1 1 RQC domain HRDC PF00570.23 EMD68851.1 - 8.1e-10 38.6 0.1 2e-09 37.3 0.1 1.7 1 0 0 1 1 1 1 HRDC domain ResIII PF04851.15 EMD68851.1 - 3.7e-07 30.3 0.0 9.8e-07 28.9 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Pyridoxal_deC PF00282.19 EMD68852.1 - 5.7e-30 104.3 0.0 1.1e-29 103.3 0.0 1.4 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Beta_elim_lyase PF01212.21 EMD68852.1 - 0.0068 15.7 0.1 0.014 14.7 0.1 1.4 1 1 0 1 1 1 1 Beta-eliminating lyase SMC_N PF02463.19 EMD68854.1 - 6.8e-74 248.0 14.1 1.7e-73 246.7 14.1 1.8 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EMD68854.1 - 6.3e-26 91.0 0.2 7.1e-25 87.6 0.0 2.6 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 EMD68854.1 - 3e-12 47.0 0.4 4.4e-05 23.4 0.0 3.4 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system Tektin PF03148.14 EMD68854.1 - 0.00023 20.1 12.5 0.00023 20.1 12.5 6.8 3 2 2 6 6 6 2 Tektin family ERM PF00769.19 EMD68854.1 - 0.00031 20.6 13.4 0.00031 20.6 13.4 6.4 2 2 4 6 6 5 1 Ezrin/radixin/moesin family AAA_29 PF13555.6 EMD68854.1 - 0.0012 18.6 0.0 0.0025 17.5 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain UPF0242 PF06785.11 EMD68854.1 - 0.0016 18.6 7.6 0.0016 18.6 7.6 7.5 4 2 4 8 8 4 1 Uncharacterised protein family (UPF0242) N-terminus MAD PF05557.13 EMD68854.1 - 0.0023 16.4 19.7 0.0023 16.4 19.7 6.0 2 2 4 7 7 7 1 Mitotic checkpoint protein DivIC PF04977.15 EMD68854.1 - 0.021 14.6 0.4 0.021 14.6 0.4 11.6 5 3 4 10 10 9 0 Septum formation initiator AAA_13 PF13166.6 EMD68854.1 - 0.094 11.3 94.5 0.15 10.6 27.0 5.5 3 2 2 5 5 5 0 AAA domain APG6_N PF17675.1 EMD68854.1 - 9 6.8 151.5 0.054 14.0 11.0 9.4 2 2 7 9 9 9 0 Apg6 coiled-coil region DUF3591 PF12157.8 EMD68855.1 - 4.9e-170 566.0 0.2 8.6e-170 565.2 0.2 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3591) zf-CCHC PF00098.23 EMD68855.1 - 0.0051 16.8 0.7 0.0089 16.1 0.7 1.4 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_6 PF15288.6 EMD68855.1 - 0.0098 15.7 1.1 0.027 14.3 1.1 1.7 1 0 0 1 1 1 1 Zinc knuckle ANTAR PF03861.14 EMD68855.1 - 0.17 11.8 1.8 0.2 11.5 0.0 2.1 2 0 0 2 2 2 0 ANTAR domain Peptidase_S8_N PF16361.5 EMD68855.1 - 1.5 9.3 4.5 1.6 9.2 0.3 2.9 3 0 0 3 3 3 0 N-terminal of Subtilase family Methyltransf_15 PF09445.10 EMD68856.1 - 6.4e-51 172.2 0.0 8e-51 171.9 0.0 1.1 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Met_10 PF02475.16 EMD68856.1 - 1.4e-08 34.7 0.0 1.7e-08 34.4 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein Cons_hypoth95 PF03602.15 EMD68856.1 - 9.9e-07 28.6 0.0 1.4e-06 28.1 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein 95 UPF0020 PF01170.18 EMD68856.1 - 7.6e-06 25.7 0.0 5.4e-05 23.0 0.0 2.0 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 N6_Mtase PF02384.16 EMD68856.1 - 0.0014 18.0 0.0 0.0019 17.5 0.0 1.2 1 0 0 1 1 1 1 N-6 DNA Methylase MTS PF05175.14 EMD68856.1 - 0.0037 16.8 0.0 0.0053 16.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.6 EMD68856.1 - 0.01 16.5 0.0 0.017 15.8 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_18 PF12847.7 EMD68856.1 - 0.01 15.8 0.0 0.015 15.2 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_5 PF01795.19 EMD68856.1 - 0.047 13.2 0.0 0.067 12.7 0.0 1.2 1 0 0 1 1 1 0 MraW methylase family RrnaAD PF00398.20 EMD68856.1 - 0.052 12.6 0.0 0.059 12.4 0.0 1.1 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase DNA_methylase PF00145.17 EMD68856.1 - 0.11 11.8 0.1 0.17 11.2 0.1 1.3 1 0 0 1 1 1 0 C-5 cytosine-specific DNA methylase PrmA PF06325.13 EMD68856.1 - 0.11 11.8 0.1 0.16 11.3 0.1 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltr_RsmB-F PF01189.17 EMD68856.1 - 0.19 11.4 0.0 0.28 10.8 0.0 1.2 1 0 0 1 1 1 0 16S rRNA methyltransferase RsmB/F GRASP55_65 PF04495.14 EMD68857.1 - 9.6e-50 168.5 0.0 8.2e-47 159.0 0.0 2.1 1 1 1 2 2 2 2 GRASP55/65 PDZ-like domain PDZ_6 PF17820.1 EMD68857.1 - 0.00032 20.5 0.1 0.1 12.4 0.1 2.4 2 0 0 2 2 2 2 PDZ domain C1_2 PF03107.16 EMD68859.1 - 0.81 10.1 8.1 2.5 8.5 8.1 1.9 1 0 0 1 1 1 0 C1 domain NOA36 PF06524.12 EMD68859.1 - 4.3 6.6 8.8 0.33 10.2 3.6 1.8 2 0 0 2 2 2 0 NOA36 protein Lactamase_B_3 PF13483.6 EMD68860.1 - 4.2e-08 33.3 0.0 1e-07 32.0 0.0 1.6 2 0 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B_2 PF12706.7 EMD68860.1 - 3.7e-05 23.3 0.2 5.9e-05 22.7 0.2 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain PIP5K PF01504.18 EMD68861.1 - 2.8e-102 341.6 0.5 2.8e-102 341.6 0.5 2.0 2 0 0 2 2 2 1 Phosphatidylinositol-4-phosphate 5-Kinase AAA PF00004.29 EMD68863.1 - 2.7e-45 154.0 0.6 6.6e-45 152.8 0.0 1.9 3 0 0 3 3 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 EMD68863.1 - 6.2e-10 38.9 0.1 4e-09 36.3 0.0 2.2 2 0 0 2 2 2 1 Proteasomal ATPase OB C-terminal domain AAA_5 PF07728.14 EMD68863.1 - 9.4e-09 35.4 0.1 3.1e-08 33.7 0.1 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 EMD68863.1 - 6.3e-08 32.9 0.0 1.4e-07 31.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 EMD68863.1 - 1.1e-07 32.4 0.1 3.5e-05 24.3 0.0 3.1 2 1 1 3 3 3 1 AAA ATPase domain DUF815 PF05673.13 EMD68863.1 - 6.7e-06 25.5 0.2 1.4e-05 24.4 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_22 PF13401.6 EMD68863.1 - 4.9e-05 23.6 1.4 0.0081 16.4 0.1 2.6 1 1 0 2 2 2 1 AAA domain AAA_lid_3 PF17862.1 EMD68863.1 - 0.00023 20.9 0.1 0.00055 19.7 0.1 1.7 1 0 0 1 1 1 1 AAA+ lid domain RuvB_N PF05496.12 EMD68863.1 - 0.00032 20.5 0.0 0.00091 19.0 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 EMD68863.1 - 0.00057 20.4 0.0 0.0016 19.0 0.0 1.7 2 0 0 2 2 1 1 AAA domain RNA_helicase PF00910.22 EMD68863.1 - 0.00077 19.8 0.0 0.0017 18.7 0.0 1.6 1 0 0 1 1 1 1 RNA helicase AAA_28 PF13521.6 EMD68863.1 - 0.001 19.3 0.0 0.0021 18.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain TsaE PF02367.17 EMD68863.1 - 0.0015 18.5 0.0 0.021 14.9 0.0 2.2 1 1 1 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE TIP49 PF06068.13 EMD68863.1 - 0.0018 17.6 0.0 0.0034 16.7 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_7 PF12775.7 EMD68863.1 - 0.0019 17.7 0.1 0.0096 15.4 0.1 1.9 1 1 0 1 1 1 1 P-loop containing dynein motor region AAA_14 PF13173.6 EMD68863.1 - 0.0019 18.2 0.1 0.0069 16.4 0.0 1.9 2 0 0 2 2 2 1 AAA domain NTPase_1 PF03266.15 EMD68863.1 - 0.0032 17.4 0.0 0.014 15.3 0.0 2.0 2 0 0 2 2 2 1 NTPase AAA_30 PF13604.6 EMD68863.1 - 0.0053 16.5 0.1 0.013 15.2 0.1 1.7 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EMD68863.1 - 0.0063 16.7 0.0 0.02 15.1 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_3 PF07726.11 EMD68863.1 - 0.0068 16.3 0.0 0.02 14.8 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 EMD68863.1 - 0.0081 16.1 0.1 0.11 12.4 0.0 2.6 2 0 0 2 2 2 1 NACHT domain Mg_chelatase PF01078.21 EMD68863.1 - 0.0086 15.5 0.0 0.019 14.3 0.0 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI TniB PF05621.11 EMD68863.1 - 0.0087 15.5 0.0 0.54 9.6 0.0 2.3 2 0 0 2 2 2 1 Bacterial TniB protein IstB_IS21 PF01695.17 EMD68863.1 - 0.017 14.8 0.1 0.044 13.5 0.0 1.8 2 0 0 2 2 1 0 IstB-like ATP binding protein AAA_24 PF13479.6 EMD68863.1 - 0.018 14.7 0.2 0.046 13.4 0.2 1.7 1 1 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 EMD68863.1 - 0.036 14.0 0.8 0.21 11.5 0.1 2.5 2 1 0 2 2 2 0 ATPase domain predominantly from Archaea ATPase PF06745.13 EMD68863.1 - 0.038 13.3 1.6 0.56 9.5 0.0 2.6 3 0 0 3 3 3 0 KaiC AAA_25 PF13481.6 EMD68863.1 - 0.04 13.5 0.7 0.26 10.9 0.1 2.3 2 1 1 3 3 3 0 AAA domain AAA_11 PF13086.6 EMD68863.1 - 0.048 13.4 0.1 0.14 11.9 0.0 1.9 2 0 0 2 2 2 0 AAA domain Viral_Hsp90 PF03225.14 EMD68863.1 - 0.05 12.1 0.0 0.08 11.4 0.0 1.2 1 0 0 1 1 1 0 Viral heat shock protein Hsp90 homologue Bac_DnaA PF00308.18 EMD68863.1 - 0.064 13.1 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 Bacterial dnaA protein Sigma54_activat PF00158.26 EMD68863.1 - 0.077 12.7 0.2 1.4 8.6 0.0 2.5 2 1 0 2 2 2 0 Sigma-54 interaction domain AFG1_ATPase PF03969.16 EMD68863.1 - 0.081 11.8 0.0 0.16 10.8 0.0 1.5 1 0 0 1 1 1 0 AFG1-like ATPase AAA_19 PF13245.6 EMD68863.1 - 0.14 12.5 0.1 0.41 11.0 0.1 1.7 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EMD68863.1 - 0.18 11.6 0.0 0.35 10.7 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Parvo_NS1 PF01057.17 EMD68863.1 - 0.21 10.7 0.0 0.39 9.8 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 ARID PF01388.21 EMD68865.1 - 3.4e-14 53.3 0.2 3.4e-14 53.3 0.2 3.1 2 1 0 2 2 2 1 ARID/BRIGHT DNA binding domain BAF250_C PF12031.8 EMD68865.1 - 0.056 12.7 0.1 0.056 12.7 0.1 3.6 2 1 0 2 2 2 0 SWI/SNF-like complex subunit BAF250/Osa Mem_trans PF03547.18 EMD68865.1 - 0.063 11.7 2.2 0.11 10.9 2.2 1.4 1 0 0 1 1 1 0 Membrane transport protein Caldesmon PF02029.15 EMD68865.1 - 1.5 7.5 50.2 0.53 9.0 45.4 2.1 2 0 0 2 2 2 0 Caldesmon SAPS PF04499.15 EMD68865.1 - 4.4 6.0 34.9 7 5.3 32.9 2.3 2 1 0 2 2 2 0 SIT4 phosphatase-associated protein RIFIN PF02009.16 EMD68865.1 - 5.7 6.7 31.6 11 5.7 31.6 1.5 1 0 0 1 1 1 0 Rifin Abhydrolase_2 PF02230.16 EMD68866.1 - 5.2e-23 82.0 0.1 4.6e-20 72.4 0.1 2.8 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_6 PF12697.7 EMD68866.1 - 0.0094 16.6 0.6 0.15 12.7 1.5 1.9 1 1 1 2 2 2 1 Alpha/beta hydrolase family Nkap_C PF06047.11 EMD68866.1 - 0.017 15.2 0.0 0.026 14.6 0.0 1.3 1 0 0 1 1 1 0 NF-kappa-B-activating protein C-terminal domain DUF1749 PF08538.10 EMD68866.1 - 0.099 11.7 0.0 0.17 10.9 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1749) Lipase_3 PF01764.25 EMD68866.1 - 0.15 11.9 0.0 0.23 11.3 0.0 1.2 1 0 0 1 1 1 0 Lipase (class 3) Hydrolase_4 PF12146.8 EMD68866.1 - 0.19 11.0 0.7 3.8 6.7 0.0 2.6 2 1 1 3 3 3 0 Serine aminopeptidase, S33 FSH1 PF03959.13 EMD68866.1 - 0.22 11.1 0.0 0.53 9.9 0.0 1.7 2 0 0 2 2 2 0 Serine hydrolase (FSH1) zf-HIT PF04438.16 EMD68867.1 - 1.5e-08 34.3 4.4 2.3e-08 33.8 4.4 1.3 1 0 0 1 1 1 1 HIT zinc finger Myosin_head PF00063.21 EMD68867.1 - 0.17 10.1 0.0 0.2 9.8 0.0 1.1 1 0 0 1 1 1 0 Myosin head (motor domain) zf-ribbon_3 PF13248.6 EMD68867.1 - 0.26 10.7 5.3 7.4 6.1 5.2 2.5 1 1 1 2 2 2 0 zinc-ribbon domain zinc_ribbon_2 PF13240.6 EMD68867.1 - 1.6 8.6 5.9 10 6.0 0.7 2.5 2 0 0 2 2 2 0 zinc-ribbon domain Rhomboid PF01694.22 EMD68869.1 - 5.3e-13 49.2 7.4 5.3e-13 49.2 7.4 1.4 2 0 0 2 2 2 1 Rhomboid family IlvGEDA_leader PF08046.11 EMD68869.1 - 0.79 9.2 3.2 2.1 7.9 3.2 1.7 1 0 0 1 1 1 0 IlvGEDA operon leader peptide Gaa1 PF04114.14 EMD68870.1 - 1.6e-165 551.9 0.2 3.1e-165 551.0 0.2 1.4 1 1 0 1 1 1 1 Gaa1-like, GPI transamidase component PCI PF01399.27 EMD68871.1 - 3e-08 34.1 0.0 8.3e-08 32.7 0.0 1.8 1 0 0 1 1 1 1 PCI domain Rpn9_C PF18261.1 EMD68871.1 - 0.00022 20.7 1.0 0.00052 19.6 1.0 1.6 1 0 0 1 1 1 1 Rpn9 C-terminal helix Glyco_transf_20 PF00982.21 EMD68871.1 - 0.028 13.1 0.1 0.045 12.4 0.1 1.2 1 0 0 1 1 1 0 Glycosyltransferase family 20 ANAPC5 PF12862.7 EMD68871.1 - 0.034 14.2 3.1 0.047 13.8 1.1 2.4 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 5 Epimerase PF01370.21 EMD68872.1 - 3.9e-14 52.7 0.0 7.3e-14 51.8 0.0 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 EMD68872.1 - 5.2e-14 52.4 0.0 6.8e-14 52.0 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EMD68872.1 - 8.5e-12 45.3 0.0 1.3e-11 44.8 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 EMD68872.1 - 2.9e-11 42.9 0.0 6.1e-11 41.8 0.0 1.5 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 EMD68872.1 - 4e-08 33.0 0.2 3.8e-07 29.8 0.1 2.0 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 EMD68872.1 - 1.3e-06 27.8 0.0 5.3e-05 22.5 0.0 2.6 1 1 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.12 EMD68872.1 - 7.1e-05 22.1 1.4 0.014 14.6 0.0 3.0 2 1 1 3 3 3 2 Male sterility protein adh_short PF00106.25 EMD68872.1 - 0.00015 21.3 0.0 0.00025 20.6 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EMD68872.1 - 0.0057 16.6 0.0 3.5 7.5 0.0 2.4 2 0 0 2 2 2 2 KR domain Polysacc_synt_2 PF02719.15 EMD68872.1 - 0.028 13.5 0.0 0.056 12.6 0.0 1.5 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein adh_short_C2 PF13561.6 EMD68872.1 - 0.045 13.3 0.0 0.065 12.8 0.0 1.3 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase NAD_synthase PF02540.17 EMD68872.1 - 0.11 11.6 0.1 0.25 10.4 0.0 1.6 2 0 0 2 2 2 0 NAD synthase DUF155 PF02582.14 EMD68873.1 - 5.7e-48 163.3 0.0 8.9e-48 162.7 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 Cupin_3 PF05899.12 EMD68873.1 - 0.016 14.9 0.0 0.032 13.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF861) Cupin_1 PF00190.22 EMD68873.1 - 0.045 13.4 0.0 0.076 12.6 0.0 1.4 1 0 0 1 1 1 0 Cupin Methyltransf_9 PF08003.11 EMD68873.1 - 0.18 10.7 0.1 0.73 8.7 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1698) Clathrin PF00637.20 EMD68874.1 - 1.4e-17 63.9 0.2 3.3e-17 62.7 0.2 1.6 1 0 0 1 1 1 1 Region in Clathrin and VPS zf-RING_UBOX PF13445.6 EMD68874.1 - 0.021 14.8 0.1 0.047 13.7 0.1 1.6 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_5 PF14634.6 EMD68874.1 - 0.042 13.8 1.3 0.046 13.7 0.1 1.7 2 0 0 2 2 2 0 zinc-RING finger domain zf-RING_11 PF17123.5 EMD68874.1 - 0.047 13.4 0.2 0.11 12.3 0.2 1.6 1 0 0 1 1 1 0 RING-like zinc finger zf-rbx1 PF12678.7 EMD68874.1 - 0.11 12.8 0.1 0.24 11.7 0.1 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 EMD68874.1 - 0.17 11.7 0.2 0.6 10.0 0.0 1.9 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) ECH_1 PF00378.20 EMD68875.1 - 8.5e-40 136.6 0.0 1.6e-39 135.8 0.0 1.4 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EMD68875.1 - 2.4e-25 89.8 0.0 2.7e-25 89.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase HIT PF01230.23 EMD68876.1 - 2.4e-23 82.7 0.4 3.5e-23 82.2 0.4 1.3 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 EMD68876.1 - 1.1e-12 48.4 0.2 1.6e-12 47.9 0.2 1.2 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.15 EMD68876.1 - 4.1e-05 23.4 0.1 5.8e-05 22.9 0.1 1.2 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 Strep_his_triad PF04270.13 EMD68876.1 - 0.06 13.3 1.1 3.1 7.9 0.1 2.3 2 0 0 2 2 2 0 Streptococcal histidine triad protein N6-adenineMlase PF10237.9 EMD68877.1 - 6e-52 175.7 0.1 7.3e-52 175.4 0.1 1.1 1 0 0 1 1 1 1 Probable N6-adenine methyltransferase Cons_hypoth95 PF03602.15 EMD68877.1 - 0.004 16.8 0.0 0.0059 16.3 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein 95 UPF0020 PF01170.18 EMD68877.1 - 0.016 14.9 0.0 0.031 14.0 0.0 1.5 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 MTS PF05175.14 EMD68877.1 - 0.15 11.6 0.0 0.24 10.9 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain BLACT_WH PF17778.1 EMD68878.1 - 2.1e-17 62.9 0.0 4e-17 61.9 0.0 1.4 1 0 0 1 1 1 1 Beta-lactamase associated winged helix domain Lactamase_B PF00753.27 EMD68878.1 - 3.3e-15 56.6 1.1 4.3e-13 49.7 1.1 2.2 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EMD68878.1 - 2.4e-06 27.2 0.3 5.5e-06 26.0 0.3 1.7 1 1 0 1 1 1 1 Beta-lactamase superfamily domain DRE2_N PF16803.5 EMD68878.1 - 0.07 13.4 0.0 0.12 12.6 0.0 1.3 1 0 0 1 1 1 0 Fe-S cluster assembly protein DRE2 N-terminus Sugar_tr PF00083.24 EMD68879.1 - 7e-125 417.4 20.4 1.2e-124 416.6 20.4 1.3 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD68879.1 - 3.8e-29 101.7 58.9 8.6e-24 84.1 33.8 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 EMD68879.1 - 0.00027 19.5 11.6 0.00056 18.5 5.6 2.1 2 0 0 2 2 2 2 Fungal trichothecene efflux pump (TRI12) MFS_1_like PF12832.7 EMD68879.1 - 1.9 7.3 19.0 0.81 8.5 3.4 3.7 2 2 1 3 3 3 0 MFS_1 like family Zn_clus PF00172.18 EMD68880.1 - 5.4e-06 26.4 13.3 1.1e-05 25.5 13.3 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Img2 PF05046.14 EMD68881.1 - 5.2e-28 97.2 0.1 7.1e-28 96.7 0.1 1.2 1 0 0 1 1 1 1 Mitochondrial large subunit ribosomal protein (Img2) eIF3_N PF09440.10 EMD68882.1 - 3.9e-42 143.9 6.3 3.9e-42 143.9 6.3 2.1 2 0 0 2 2 2 1 eIF3 subunit 6 N terminal domain PCI PF01399.27 EMD68882.1 - 6.4e-16 58.8 0.4 2.6e-15 56.8 0.0 2.2 2 0 0 2 2 2 1 PCI domain RPN7 PF10602.9 EMD68882.1 - 0.024 14.3 0.2 0.057 13.1 0.0 1.7 2 0 0 2 2 2 0 26S proteasome subunit RPN7 Frag1 PF10277.9 EMD68883.1 - 5e-38 130.8 10.1 5e-38 130.8 10.1 3.0 3 1 0 3 3 3 1 Frag1/DRAM/Sfk1 family Exo_endo_phos PF03372.23 EMD68883.1 - 0.035 13.6 0.0 0.069 12.7 0.0 1.4 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family U3_assoc_6 PF08640.11 EMD68884.1 - 1.3e-24 86.1 3.4 1.3e-24 86.1 3.4 2.2 2 0 0 2 2 2 1 U3 small nucleolar RNA-associated protein 6 TPR_14 PF13428.6 EMD68884.1 - 0.0077 17.0 3.0 0.52 11.3 0.0 4.1 2 2 3 5 5 5 1 Tetratricopeptide repeat NRDE-2 PF08424.10 EMD68884.1 - 0.14 11.3 0.1 0.34 10.0 0.1 1.8 1 0 0 1 1 1 0 NRDE-2, necessary for RNA interference RF-1 PF00472.20 EMD68885.1 - 3.1e-17 62.6 0.3 4.5e-17 62.0 0.3 1.2 1 0 0 1 1 1 1 RF-1 domain M20_dimer PF07687.14 EMD68885.1 - 0.098 12.6 0.1 0.23 11.4 0.0 1.6 2 0 0 2 2 2 0 Peptidase dimerisation domain RRM_1 PF00076.22 EMD68886.1 - 8.2e-08 32.0 0.0 1.5e-07 31.1 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EMD68886.1 - 0.026 14.1 0.0 0.054 13.1 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 EMD68886.1 - 0.067 13.3 0.0 0.13 12.3 0.0 1.5 1 0 0 1 1 1 0 Limkain b1 LETM1 PF07766.13 EMD68888.1 - 7.2e-12 45.2 0.1 2.9e-07 30.1 0.0 2.1 2 0 0 2 2 2 2 LETM1-like protein DUF2013 PF09431.10 EMD68889.1 - 3.2e-49 166.6 0.5 3.2e-49 166.6 0.5 2.4 2 1 0 2 2 2 1 Protein of unknown function (DUF2013) MFS_1 PF07690.16 EMD68890.1 - 1.2e-30 106.7 29.4 1.9e-25 89.6 29.4 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily DUF3176 PF11374.8 EMD68892.1 - 3.2e-21 75.5 1.5 1.4e-19 70.3 1.5 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF3176) ubiquitin PF00240.23 EMD68894.1 - 1.3e-11 44.0 0.0 2.7e-11 43.0 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin family zf-AN1 PF01428.16 EMD68894.1 - 2e-10 40.7 7.6 2e-10 40.7 7.6 1.5 1 1 0 1 1 1 1 AN1-like Zinc finger Sde2_N_Ubi PF13019.6 EMD68894.1 - 0.00089 19.1 0.3 0.0015 18.4 0.3 1.3 1 0 0 1 1 1 1 Silencing defective 2 N-terminal ubiquitin domain DUF2407 PF10302.9 EMD68894.1 - 0.015 15.8 0.0 0.019 15.5 0.0 1.4 1 1 0 1 1 1 0 DUF2407 ubiquitin-like domain Rad60-SLD PF11976.8 EMD68894.1 - 0.033 14.0 0.0 0.054 13.3 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Acyl-CoA_dh_1 PF00441.24 EMD68895.1 - 1.9e-34 119.1 0.6 3.1e-34 118.3 0.6 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Cyt-b5 PF00173.28 EMD68895.1 - 1.6e-20 73.0 0.0 5e-20 71.4 0.0 1.9 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Acyl-CoA_dh_M PF02770.19 EMD68895.1 - 4.1e-17 62.2 0.4 7.4e-17 61.3 0.4 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 EMD68895.1 - 1.2e-07 32.4 0.2 3.6e-07 30.8 0.0 2.0 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 EMD68895.1 - 1.7e-07 31.6 0.0 3.5e-07 30.6 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Gag_p19 PF02228.16 EMD68896.1 - 0.011 16.2 0.2 0.015 15.7 0.2 1.4 1 0 0 1 1 1 0 Major core protein p19 adh_short PF00106.25 EMD68897.1 - 4.6e-09 36.0 0.0 5.3e-09 35.8 0.0 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD68897.1 - 2.3e-06 27.3 0.0 2.7e-05 23.8 0.0 1.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Importin_rep_4 PF18808.1 EMD68898.1 - 8.4e-37 125.4 3.8 1.6e-35 121.2 1.7 3.6 2 1 1 3 3 3 1 Importin repeat Importin_rep_5 PF18816.1 EMD68898.1 - 5.7e-23 81.0 2.2 2.5e-22 78.9 2.2 2.2 1 0 0 1 1 1 1 Importin repeat HEAT_EZ PF13513.6 EMD68898.1 - 1.1e-19 70.5 13.5 8.4e-11 42.1 0.7 8.4 8 2 1 9 9 8 2 HEAT-like repeat HEAT PF02985.22 EMD68898.1 - 7e-19 66.3 12.0 0.00024 21.1 0.1 11.2 10 0 0 10 10 10 2 HEAT repeat HEAT_2 PF13646.6 EMD68898.1 - 1e-18 67.4 9.3 7.3e-10 39.1 0.4 7.6 5 1 2 7 7 6 3 HEAT repeats Importin_rep_6 PF18829.1 EMD68898.1 - 3.4e-11 43.2 0.5 3.4e-11 43.2 0.5 3.9 4 0 0 4 4 4 1 Importin repeat 6 Vac14_Fab1_bd PF12755.7 EMD68898.1 - 7.1e-10 39.4 0.2 0.017 15.7 0.0 5.9 3 2 2 5 5 5 2 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 EMD68898.1 - 1.4e-07 31.7 2.2 0.0011 19.0 0.1 4.6 3 2 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 MMS19_C PF12460.8 EMD68898.1 - 8.5e-07 28.4 1.2 8.5e-07 28.4 1.2 4.0 4 2 1 5 5 5 1 RNAPII transcription regulator C-terminal DUF3385 PF11865.8 EMD68898.1 - 1e-06 28.7 0.4 0.16 11.8 0.1 5.9 5 2 1 6 6 6 1 Domain of unknown function (DUF3385) CLASP_N PF12348.8 EMD68898.1 - 3.4e-06 26.8 0.3 0.017 14.7 0.1 4.3 4 1 1 5 5 5 2 CLASP N terminal RIX1 PF08167.12 EMD68898.1 - 1.2e-05 25.2 0.1 0.0025 17.6 0.1 3.9 3 1 1 4 4 4 1 rRNA processing/ribosome biogenesis DUF4042 PF13251.6 EMD68898.1 - 0.0012 18.6 0.8 6 6.5 0.0 4.5 3 1 1 4 4 4 1 Domain of unknown function (DUF4042) RTP1_C1 PF10363.9 EMD68898.1 - 0.0021 18.2 0.7 0.61 10.3 0.3 4.6 5 0 0 5 5 5 1 Required for nuclear transport of RNA pol II C-terminus 1 Cohesin_HEAT PF12765.7 EMD68898.1 - 0.0024 18.1 0.0 0.76 10.1 0.0 2.8 2 0 0 2 2 2 1 HEAT repeat associated with sister chromatid cohesion MMS19_N PF14500.6 EMD68898.1 - 0.043 13.4 6.8 3.3 7.2 0.1 4.5 4 1 1 5 5 5 0 Dos2-interacting transcription regulator of RNA-Pol-II TFCD_C PF12612.8 EMD68898.1 - 0.068 13.0 4.4 37 4.1 0.3 4.9 5 2 0 5 5 5 0 Tubulin folding cofactor D C terminal DUF668 PF05003.12 EMD68898.1 - 0.14 12.7 0.2 4 8.0 0.0 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF668) V-ATPase_H_N PF03224.14 EMD68898.1 - 0.45 9.8 5.1 0.51 9.6 0.1 3.1 3 1 0 3 3 3 0 V-ATPase subunit H Arm PF00514.23 EMD68898.1 - 3.6 7.8 12.3 6.7 6.9 0.0 5.2 7 0 0 7 7 6 0 Armadillo/beta-catenin-like repeat CBS PF00571.28 EMD68899.1 - 2.2e-34 117.7 6.7 1.6e-09 38.1 0.0 4.9 5 0 0 5 5 5 4 CBS domain PB1 PF00564.24 EMD68899.1 - 1.6e-09 37.5 0.3 4.4e-09 36.1 0.0 1.9 2 0 0 2 2 2 1 PB1 domain Ribosomal_S26e PF01283.19 EMD68900.1 - 9e-52 174.1 8.0 1.1e-51 173.8 8.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S26e zf_CopZ PF18423.1 EMD68900.1 - 0.023 14.7 0.5 0.061 13.3 0.0 1.9 2 0 0 2 2 2 0 Zinc binding domain DUF4668 PF15701.5 EMD68900.1 - 0.085 12.7 0.4 0.13 12.0 0.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4668) DUF1918 PF08940.11 EMD68900.1 - 0.094 12.4 0.0 0.19 11.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1918) SF1-HH PF16275.5 EMD68900.1 - 0.18 12.2 2.4 0.28 11.5 2.4 1.5 1 1 0 1 1 1 0 Splicing factor 1 helix-hairpin domain VanZ PF04892.12 EMD68901.1 - 1.9e-05 25.3 2.0 3e-05 24.7 2.0 1.3 1 1 0 1 1 1 1 VanZ like family Phage_holin_2_4 PF16082.5 EMD68901.1 - 0.11 12.2 0.1 1.1 9.1 0.1 2.3 2 0 0 2 2 2 0 Bacteriophage holin family, superfamily II-like Bromodomain PF00439.25 EMD68902.1 - 2.3e-20 72.5 0.7 6.5e-20 71.0 0.7 1.8 1 0 0 1 1 1 1 Bromodomain Bromo_TP PF07524.13 EMD68902.1 - 4.1e-06 26.7 0.1 2e-05 24.5 0.0 2.1 2 0 0 2 2 2 1 Bromodomain associated LAT PF15234.6 EMD68902.1 - 3.7 7.2 14.2 0.55 9.9 7.8 2.6 2 0 0 2 2 2 0 Linker for activation of T-cells Rhomboid PF01694.22 EMD68904.1 - 2.2e-15 56.9 9.7 2.2e-15 56.9 9.7 1.4 2 0 0 2 2 2 1 Rhomboid family RseC_MucC PF04246.12 EMD68904.1 - 0.37 10.7 3.1 9.5 6.2 0.9 2.2 2 0 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC DEAD PF00270.29 EMD68905.1 - 3.5e-42 144.1 0.0 5e-42 143.6 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EMD68905.1 - 3.6e-28 98.1 0.5 5.8e-27 94.2 0.5 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EMD68905.1 - 0.0024 17.9 0.0 0.0044 17.0 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit COG5 PF10392.9 EMD68906.1 - 1.6e-42 144.8 3.9 9.4e-42 142.3 0.1 2.7 2 0 0 2 2 2 1 Golgi transport complex subunit 5 STG PF15809.5 EMD68906.1 - 0.062 13.4 4.0 0.13 12.4 4.0 1.5 1 0 0 1 1 1 0 Simian taste bud-specific gene product family DUF2285 PF10074.9 EMD68906.1 - 1.4 9.6 4.2 1.6 9.4 0.4 3.0 2 2 1 3 3 3 0 Uncharacterized conserved protein (DUF2285) AAA PF00004.29 EMD68907.1 - 2.8e-42 144.3 0.0 4.8e-42 143.5 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 EMD68907.1 - 3.2e-29 100.7 0.2 1.9e-28 98.2 0.1 2.4 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain MIT PF04212.18 EMD68907.1 - 2.6e-23 81.9 5.3 2.6e-23 81.9 5.3 1.8 2 0 0 2 2 1 1 MIT (microtubule interacting and transport) domain AAA_lid_3 PF17862.1 EMD68907.1 - 7.1e-06 25.7 0.0 7.9e-05 22.4 0.0 2.4 2 0 0 2 2 2 1 AAA+ lid domain RuvB_N PF05496.12 EMD68907.1 - 1.2e-05 25.1 0.0 2.7e-05 24.0 0.0 1.7 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EMD68907.1 - 2e-05 25.0 0.1 0.00023 21.6 0.0 2.5 2 1 0 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 EMD68907.1 - 3.7e-05 23.8 0.0 0.00018 21.5 0.0 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 EMD68907.1 - 6.1e-05 23.4 0.0 0.012 16.0 0.0 2.6 2 0 0 2 2 2 1 RNA helicase AAA_2 PF07724.14 EMD68907.1 - 9.3e-05 22.6 0.0 0.0016 18.6 0.0 2.4 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) IstB_IS21 PF01695.17 EMD68907.1 - 0.0001 22.1 0.0 0.00026 20.8 0.0 1.6 1 1 0 1 1 1 1 IstB-like ATP binding protein TIP49 PF06068.13 EMD68907.1 - 0.00018 20.8 0.0 0.00034 19.9 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_22 PF13401.6 EMD68907.1 - 0.00031 21.0 0.1 0.02 15.2 0.0 2.6 1 1 1 2 2 2 1 AAA domain DUF815 PF05673.13 EMD68907.1 - 0.00034 19.8 0.0 0.0013 17.9 0.0 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF815) AAA_14 PF13173.6 EMD68907.1 - 0.00057 19.9 0.0 0.0012 18.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EMD68907.1 - 0.00078 20.0 0.1 0.0031 18.1 0.0 2.1 2 1 0 2 2 1 1 AAA domain AAA_33 PF13671.6 EMD68907.1 - 0.0018 18.4 0.0 0.0042 17.2 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.6 EMD68907.1 - 0.0033 17.2 0.0 0.012 15.4 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 EMD68907.1 - 0.0048 16.4 0.0 0.038 13.5 0.0 2.3 2 1 0 2 2 2 1 P-loop containing dynein motor region AAA_17 PF13207.6 EMD68907.1 - 0.013 15.9 0.1 0.054 13.9 0.0 2.1 2 0 0 2 2 2 0 AAA domain Phage_GPO PF05929.11 EMD68907.1 - 0.016 14.9 0.4 0.027 14.1 0.4 1.3 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase Mg_chelatase PF01078.21 EMD68907.1 - 0.025 13.9 0.1 0.08 12.3 0.0 1.8 3 0 0 3 3 2 0 Magnesium chelatase, subunit ChlI Torsin PF06309.11 EMD68907.1 - 0.043 13.9 0.0 0.099 12.8 0.0 1.5 1 0 0 1 1 1 0 Torsin Sigma54_activat PF00158.26 EMD68907.1 - 0.053 13.2 0.0 0.17 11.5 0.0 1.9 1 1 0 1 1 1 0 Sigma-54 interaction domain Parvo_NS1 PF01057.17 EMD68907.1 - 0.063 12.4 0.0 0.11 11.6 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_25 PF13481.6 EMD68907.1 - 0.068 12.7 0.1 0.72 9.4 0.1 2.2 1 1 0 2 2 2 0 AAA domain USP8_dimer PF08969.11 EMD68907.1 - 0.077 13.2 4.7 0.069 13.3 3.4 1.6 2 0 0 2 2 1 0 USP8 dimerisation domain PhoH PF02562.16 EMD68907.1 - 0.084 12.3 0.1 0.16 11.4 0.1 1.4 1 0 0 1 1 1 0 PhoH-like protein NACHT PF05729.12 EMD68907.1 - 0.12 12.3 0.0 0.64 9.9 0.0 2.0 1 1 1 2 2 2 0 NACHT domain Cytidylate_kin PF02224.18 EMD68907.1 - 0.16 11.7 0.1 0.53 10.0 0.1 1.9 2 0 0 2 2 1 0 Cytidylate kinase AFG1_ATPase PF03969.16 EMD68907.1 - 0.18 10.7 0.0 0.34 9.7 0.0 1.4 1 0 0 1 1 1 0 AFG1-like ATPase Prefoldin_2 PF01920.20 EMD68908.1 - 5.5e-17 61.7 6.0 6.5e-17 61.4 6.0 1.1 1 0 0 1 1 1 1 Prefoldin subunit Spc24 PF08286.11 EMD68908.1 - 0.0093 16.2 2.2 0.011 16.0 2.2 1.1 1 0 0 1 1 1 1 Spc24 subunit of Ndc80 HDV_ag PF01517.18 EMD68908.1 - 0.066 13.0 0.1 0.071 12.9 0.1 1.2 1 0 0 1 1 1 0 Hepatitis delta virus delta antigen DivIC PF04977.15 EMD68908.1 - 0.23 11.3 9.7 0.24 11.2 2.3 2.2 1 1 1 2 2 2 0 Septum formation initiator SAM_2 PF07647.17 EMD68909.1 - 4.5e-08 33.1 0.1 1e-07 32.0 0.1 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 EMD68909.1 - 1e-05 25.9 0.2 3.3e-05 24.2 0.2 1.9 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) HemN_C PF06969.16 EMD68909.1 - 0.055 13.5 1.6 0.78 9.8 0.2 3.0 3 0 0 3 3 3 0 HemN C-terminal domain IGR PF09597.10 EMD68909.1 - 0.084 13.0 0.1 0.18 11.9 0.1 1.5 1 0 0 1 1 1 0 IGR protein motif DUF4508 PF14969.6 EMD68909.1 - 0.12 12.7 0.2 0.29 11.4 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4508) FRB_dom PF08771.11 EMD68909.1 - 0.13 12.7 0.2 0.41 11.1 0.2 1.8 1 0 0 1 1 1 0 FKBP12-rapamycin binding domain Fungal_trans PF04082.18 EMD68910.1 - 1.9e-10 40.3 0.2 4.2e-10 39.1 0.2 1.5 1 1 0 1 1 1 1 Fungal specific transcription factor domain MFS_1 PF07690.16 EMD68911.1 - 3.8e-35 121.5 22.2 3.8e-35 121.5 22.2 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF1772 PF08592.11 EMD68911.1 - 0.49 10.7 11.5 1.7 9.0 1.9 3.5 2 2 1 3 3 3 0 Domain of unknown function (DUF1772) HET PF06985.11 EMD68912.1 - 2.1e-07 31.4 0.1 2.3e-07 31.2 0.1 1.0 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) QRPTase_C PF01729.19 EMD68914.1 - 2e-54 183.9 0.1 2.5e-54 183.6 0.1 1.1 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain QRPTase_N PF02749.16 EMD68914.1 - 7.4e-23 80.4 0.1 2.4e-22 78.8 0.0 1.9 2 0 0 2 2 2 1 Quinolinate phosphoribosyl transferase, N-terminal domain baeRF_family11 PF18855.1 EMD68914.1 - 0.047 14.0 0.0 0.084 13.2 0.0 1.4 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 11 KDGP_aldolase PF07071.11 EMD68914.1 - 0.2 11.4 1.8 6.1 6.6 0.5 2.3 2 0 0 2 2 2 0 KDGP aldolase Adenylsucc_synt PF00709.21 EMD68916.1 - 5.9e-173 575.6 0.1 7.3e-173 575.3 0.1 1.1 1 0 0 1 1 1 1 Adenylosuccinate synthetase MFS_1 PF07690.16 EMD68916.1 - 1.4e-32 113.0 31.6 2.4e-32 112.3 31.6 1.4 1 0 0 1 1 1 1 Major Facilitator Superfamily PMP1_2 PF08114.11 EMD68916.1 - 0.011 15.5 0.3 0.044 13.5 0.3 2.1 1 0 0 1 1 1 0 ATPase proteolipid family PBP PF01161.20 EMD68917.1 - 1.6e-13 51.1 0.0 2.1e-13 50.7 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein AflR PF08493.10 EMD68917.1 - 0.054 13.0 0.4 0.054 13.0 0.4 1.9 2 0 0 2 2 2 0 Aflatoxin regulatory protein TPP_enzyme_N PF02776.18 EMD68918.1 - 4.2e-32 111.1 0.0 7.5e-32 110.3 0.0 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 EMD68918.1 - 2e-20 72.9 0.0 3.7e-20 72.0 0.0 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 EMD68918.1 - 4.7e-12 45.9 0.0 9.5e-12 45.0 0.0 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Vpu PF00558.19 EMD68919.1 - 0.9 9.4 4.3 1.8 8.4 4.3 1.4 1 0 0 1 1 1 0 Vpu protein Pkinase PF00069.25 EMD68920.1 - 1.6e-64 217.8 0.0 2.2e-64 217.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD68920.1 - 1.4e-45 155.6 0.0 2.3e-45 154.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMD68920.1 - 9.1e-10 38.3 0.0 2.1e-06 27.3 0.0 2.2 2 0 0 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 EMD68920.1 - 0.011 14.5 0.0 0.022 13.5 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase Kdo PF06293.14 EMD68920.1 - 0.018 14.4 0.0 0.033 13.5 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family SAM_3 PF18016.1 EMD68920.1 - 0.099 12.5 0.1 0.22 11.3 0.1 1.5 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) APH PF01636.23 EMD68920.1 - 0.13 12.2 0.0 0.28 11.1 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family LacY_symp PF01306.19 EMD68921.1 - 1.8e-05 23.7 1.0 1.9e-05 23.6 1.0 1.0 1 0 0 1 1 1 1 LacY proton/sugar symporter Tyrosinase PF00264.20 EMD68922.1 - 1.7e-42 146.2 0.0 4.1e-42 145.0 0.0 1.7 1 0 0 1 1 1 1 Common central domain of tyrosinase Tyosinase_C PF18132.1 EMD68922.1 - 2.3e-22 79.9 0.0 2.7e-15 57.1 0.0 2.3 1 1 1 2 2 2 2 Tyosinase C-terminal domain zf-H2C2 PF09337.10 EMD68923.1 - 1.4e-15 57.2 1.6 2.4e-15 56.5 1.6 1.4 1 0 0 1 1 1 1 H2C2 zinc finger Integrase_H2C2 PF17921.1 EMD68923.1 - 6.9e-12 45.3 0.3 1.1e-11 44.6 0.3 1.3 1 0 0 1 1 1 1 Integrase zinc binding domain Acetyltransf_1 PF00583.25 EMD68923.1 - 5.5e-05 23.4 0.0 0.0001 22.5 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_4 PF13420.7 EMD68923.1 - 0.0063 16.7 0.0 0.012 15.8 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain CCDC73 PF15818.5 EMD68923.1 - 0.072 10.9 0.3 0.12 10.2 0.3 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 73 family zf-H3C2 PF16721.5 EMD68923.1 - 0.2 12.0 0.0 0.42 11.0 0.0 1.5 1 0 0 1 1 1 0 Zinc-finger like, probable DNA-binding TFIIA PF03153.13 EMD68923.1 - 0.34 10.8 11.4 0.44 10.5 11.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Inj_translocase PF16928.5 EMD68923.1 - 0.78 9.1 6.4 3 7.2 3.5 2.3 2 0 0 2 2 2 0 DNA/protein translocase of phage P22 injectosome DUF4551 PF15087.6 EMD68923.1 - 3.9 6.2 6.4 5 5.8 6.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Mog1 PF04603.12 EMD68924.1 - 4.7e-36 124.2 0.0 5.9e-36 123.9 0.0 1.1 1 0 0 1 1 1 1 Ran-interacting Mog1 protein zf-C2H2_jaz PF12171.8 EMD68925.1 - 3.7e-09 36.6 2.4 7.9e-09 35.6 2.4 1.6 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-U1 PF06220.12 EMD68925.1 - 0.00078 19.2 0.3 0.0018 18.0 0.3 1.6 1 0 0 1 1 1 1 U1 zinc finger zf-met PF12874.7 EMD68925.1 - 0.0012 19.1 0.8 0.0023 18.2 0.8 1.5 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2 PF00096.26 EMD68925.1 - 0.24 11.9 0.2 0.24 11.9 0.2 1.8 2 0 0 2 2 2 0 Zinc finger, C2H2 type Aconitase PF00330.20 EMD68926.1 - 3.2e-152 507.8 0.0 4.1e-152 507.4 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 EMD68926.1 - 1.2e-45 155.0 0.0 2e-45 154.3 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain SprT-like PF10263.9 EMD68927.1 - 1.8e-37 127.7 0.6 3.3e-37 126.8 0.6 1.5 1 0 0 1 1 1 1 SprT-like family Zn_ribbon_SprT PF17283.2 EMD68927.1 - 3.8e-09 36.3 4.4 6.9e-09 35.5 4.4 1.5 1 0 0 1 1 1 1 SprT-like zinc ribbon domain Zn-ribbon_8 PF09723.10 EMD68927.1 - 0.016 15.3 1.7 0.038 14.1 1.7 1.7 1 0 0 1 1 1 0 Zinc ribbon domain DUF4379 PF14311.6 EMD68927.1 - 0.1 13.0 2.1 0.47 10.9 2.1 2.2 1 0 0 1 1 1 0 Probable Zinc-ribbon domain DNA_pol_A_exo1 PF01612.20 EMD68928.1 - 0.05 13.3 0.2 0.26 11.0 0.2 2.2 1 1 0 1 1 1 0 3'-5' exonuclease DUF842 PF05811.13 EMD68928.1 - 0.56 9.9 6.1 0.1 12.3 2.3 1.7 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF842) FMO-like PF00743.19 EMD68929.1 - 1.4e-12 46.8 0.0 6.7e-09 34.7 0.0 2.3 2 0 0 2 2 2 2 Flavin-binding monooxygenase-like K_oxygenase PF13434.6 EMD68929.1 - 2.6e-10 40.0 0.1 3.6e-09 36.2 0.0 2.4 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.6 EMD68929.1 - 3.3e-10 39.7 0.0 1.7e-07 30.8 0.0 2.5 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EMD68929.1 - 6.1e-10 38.8 0.0 1.7e-07 30.8 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EMD68929.1 - 8.5e-06 25.9 0.0 8.3e-05 22.7 0.0 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 EMD68929.1 - 6.4e-05 22.3 0.0 0.0011 18.3 0.0 2.2 2 0 0 2 2 2 1 Thi4 family DAO PF01266.24 EMD68929.1 - 7.9e-05 22.4 0.0 2 7.9 0.0 3.3 3 0 0 3 3 3 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EMD68929.1 - 0.0043 16.2 0.1 3.3 6.7 0.0 2.6 2 1 1 3 3 3 2 FAD binding domain NAD_binding_9 PF13454.6 EMD68929.1 - 0.026 14.5 0.2 3.5 7.6 0.0 3.1 3 0 0 3 3 3 0 FAD-NAD(P)-binding Amino_oxidase PF01593.24 EMD68929.1 - 0.039 13.2 0.1 1.2 8.4 0.0 2.7 3 0 0 3 3 3 0 Flavin containing amine oxidoreductase Auxin_repressed PF05564.12 EMD68929.1 - 0.12 13.1 0.3 6.1 7.6 0.0 3.0 3 0 0 3 3 3 0 Dormancy/auxin associated protein HI0933_like PF03486.14 EMD68929.1 - 0.31 9.7 0.4 19 3.8 0.0 2.7 3 0 0 3 3 3 0 HI0933-like protein Ureidogly_lyase PF04115.12 EMD68930.1 - 2.5e-73 245.9 0.0 3e-73 245.6 0.0 1.1 1 0 0 1 1 1 1 Ureidoglycolate lyase eIF2A PF08662.11 EMD68931.1 - 1.5e-80 269.7 0.1 6.4e-80 267.6 0.0 2.0 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A WD40 PF00400.32 EMD68931.1 - 0.001 19.8 0.3 12 6.9 0.0 5.1 4 1 0 5 5 5 1 WD domain, G-beta repeat PD40 PF07676.12 EMD68931.1 - 0.034 14.1 1.4 30 4.7 0.0 4.3 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat KGG PF10685.9 EMD68932.1 - 1.2e-18 66.8 6.5 7.9e-10 38.7 0.1 3.6 3 0 0 3 3 3 3 Stress-induced bacterial acidophilic repeat motif UDG PF03167.19 EMD68933.1 - 9.4e-21 74.4 0.0 1.7e-20 73.5 0.0 1.3 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily ThuA PF06283.11 EMD68934.1 - 1.2e-52 179.2 0.1 1.4e-52 179.0 0.1 1.0 1 0 0 1 1 1 1 Trehalose utilisation Cytotoxic PF09000.10 EMD68934.1 - 0.095 13.0 0.1 0.17 12.2 0.1 1.4 1 0 0 1 1 1 0 Cytotoxic DUF4350 PF14258.6 EMD68934.1 - 0.17 12.3 0.0 0.36 11.3 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4350) p450 PF00067.22 EMD68935.1 - 7.8e-62 209.5 0.0 1.2e-61 208.9 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 peroxidase PF00141.23 EMD68937.1 - 3.3e-31 108.7 0.1 4.3e-31 108.4 0.1 1.2 1 0 0 1 1 1 1 Peroxidase DUF1799 PF08809.11 EMD68937.1 - 0.0064 16.6 0.0 0.018 15.2 0.0 1.7 2 0 0 2 2 2 1 Phage related hypothetical protein (DUF1799) Fungal_trans_2 PF11951.8 EMD68938.1 - 8.7e-32 110.4 0.2 1.1e-31 110.1 0.2 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD68938.1 - 3.7e-06 26.9 12.6 3.7e-06 26.9 12.6 1.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Glyco_hydro_45 PF02015.16 EMD68939.1 - 1.3e-67 227.8 15.7 1.6e-67 227.5 15.7 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 45 WLM PF08325.10 EMD68940.1 - 9.8e-29 100.8 0.3 2e-28 99.8 0.1 1.7 2 0 0 2 2 2 1 WLM domain DUF45 PF01863.17 EMD68940.1 - 1.2e-09 38.6 0.3 2.6e-09 37.4 0.3 1.5 1 0 0 1 1 1 1 Protein of unknown function DUF45 TF_Zn_Ribbon PF08271.12 EMD68940.1 - 0.034 13.7 3.8 0.14 11.7 0.1 2.6 2 0 0 2 2 2 0 TFIIB zinc-binding zf-RanBP PF00641.18 EMD68940.1 - 0.12 11.8 7.6 0.13 11.6 0.6 2.7 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others Prp31_C PF09785.9 EMD68940.1 - 0.13 13.2 5.6 0.061 14.2 2.8 1.9 2 0 0 2 2 2 0 Prp31 C terminal domain DZR PF12773.7 EMD68940.1 - 0.33 11.0 6.8 0.83 9.7 6.8 1.7 1 0 0 1 1 1 0 Double zinc ribbon Zn_ribbon_17 PF17120.5 EMD68940.1 - 1.9 8.2 7.2 0.62 9.7 4.2 1.7 1 1 0 1 1 1 0 Zinc-ribbon, C4HC2 type PACT_coil_coil PF10495.9 EMD68941.1 - 9.8e-05 22.9 0.1 0.00017 22.1 0.0 1.5 2 0 0 2 2 2 1 Pericentrin-AKAP-450 domain of centrosomal targeting protein Spc110_C PF18520.1 EMD68941.1 - 0.0059 16.2 0.5 0.0081 15.7 0.5 1.2 1 0 0 1 1 1 1 Spindle pole body component 110 C-terminal domain SSP160 PF06933.11 EMD68941.1 - 0.01 14.1 0.3 0.011 14.0 0.3 1.0 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 DUF4231 PF14015.6 EMD68941.1 - 0.029 14.8 0.0 0.04 14.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4231) Myc-LZ PF02344.15 EMD68941.1 - 0.035 14.2 1.9 0.065 13.3 1.9 1.4 1 0 0 1 1 1 0 Myc leucine zipper domain SGT1 PF07093.11 EMD68942.1 - 1.5e-79 268.0 12.9 1.7e-78 264.6 0.1 2.3 1 1 1 2 2 2 2 SGT1 protein Phage_X PF05155.15 EMD68943.1 - 0.025 15.0 0.0 0.053 13.9 0.0 1.5 1 0 0 1 1 1 0 Phage X family YdiH PF15930.5 EMD68943.1 - 0.097 12.9 0.4 0.097 12.9 0.4 2.1 2 1 0 2 2 2 0 Domain of unknown function LRR_6 PF13516.6 EMD68943.1 - 0.099 12.8 0.2 0.7 10.1 0.0 2.4 2 0 0 2 2 2 0 Leucine Rich repeat LRR_4 PF12799.7 EMD68943.1 - 0.15 12.5 3.9 13 6.4 0.1 4.2 4 1 0 4 4 4 0 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EMD68943.1 - 0.3 11.8 4.5 0.46 11.2 0.1 3.5 3 1 0 3 3 3 0 Leucine Rich Repeat Kinesin PF00225.23 EMD68945.1 - 9.8e-111 369.9 0.3 2.5e-110 368.6 0.3 1.7 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EMD68945.1 - 6.4e-27 94.3 0.0 2.8e-26 92.3 0.0 2.1 1 0 0 1 1 1 1 Microtubule binding UPF0184 PF03670.13 EMD68945.1 - 0.012 15.9 0.1 3.9 7.9 0.1 3.6 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0184) AFP_2 PF18815.1 EMD68945.1 - 0.065 13.5 0.1 22 5.4 0.1 3.1 3 0 0 3 3 3 0 Bacterial antifreeze protein repeat TSC22 PF01166.18 EMD68945.1 - 0.073 13.4 0.5 0.073 13.4 0.5 5.0 6 0 0 6 6 6 0 TSC-22/dip/bun family M20_dimer PF07687.14 EMD68945.1 - 0.13 12.2 0.1 0.43 10.5 0.1 1.9 1 0 0 1 1 1 0 Peptidase dimerisation domain HOOK PF05622.12 EMD68945.1 - 1 7.4 62.5 0.16 10.1 37.5 2.8 3 1 0 3 3 3 0 HOOK protein Sox_N PF12444.8 EMD68945.1 - 5.4 8.2 0.0 5.4 8.2 0.0 3.9 4 1 0 4 4 4 0 Sox developmental protein N terminal DUF4939 PF16297.5 EMD68946.1 - 0.022 14.6 0.0 0.022 14.6 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4939) zf-CCHC PF00098.23 EMD68947.1 - 5.1e-07 29.5 15.2 1.2e-05 25.1 1.2 4.1 4 0 0 4 4 4 2 Zinc knuckle zf-CCHC_2 PF13696.6 EMD68947.1 - 0.00054 19.7 0.8 0.00054 19.7 0.8 3.6 5 0 0 5 5 5 1 Zinc knuckle zf-CCHC_4 PF14392.6 EMD68947.1 - 0.008 15.9 4.3 1.1 9.0 0.3 2.5 2 0 0 2 2 2 2 Zinc knuckle MSA_2 PF00985.17 EMD68947.1 - 0.24 11.7 2.3 14 6.0 0.2 2.3 2 0 0 2 2 2 0 Merozoite Surface Antigen 2 (MSA-2) family zf-CCHC_5 PF14787.6 EMD68947.1 - 0.25 11.1 15.8 0.42 10.4 1.1 4.2 4 0 0 4 4 4 0 GAG-polyprotein viral zinc-finger Integrase_H2C2 PF17921.1 EMD68949.1 - 1.2e-07 31.8 0.0 1.8e-07 31.1 0.0 1.3 1 0 0 1 1 1 1 Integrase zinc binding domain Lactamase_B_2 PF12706.7 EMD68950.1 - 2.6e-17 63.0 0.4 3.7e-17 62.5 0.4 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 EMD68950.1 - 1.1e-13 51.4 0.8 3.7e-13 49.7 0.8 1.8 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 EMD68950.1 - 0.0047 17.0 4.0 0.012 15.6 3.9 1.8 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily DDE_1 PF03184.19 EMD68952.1 - 1.5e-09 37.8 0.0 1.6e-09 37.7 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease Borrelia_P13 PF05628.12 EMD68955.1 - 0.07 13.1 0.1 0.12 12.4 0.1 1.4 1 0 0 1 1 1 0 Borrelia membrane protein P13 Tannase PF07519.11 EMD68957.1 - 4e-99 332.7 0.8 4.7e-99 332.4 0.8 1.0 1 0 0 1 1 1 1 Tannase and feruloyl esterase Glyco_hydro_61 PF03443.14 EMD68959.1 - 1.1e-35 123.5 0.2 1.3e-35 123.3 0.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 DERM PF14704.6 EMD68959.1 - 0.072 13.6 0.0 0.63 10.5 0.0 2.0 2 0 0 2 2 2 0 Dermatopontin Esterase PF00756.20 EMD68960.1 - 0.0015 18.2 0.1 0.0053 16.4 0.1 1.7 1 1 0 1 1 1 1 Putative esterase Peptidase_S9 PF00326.21 EMD68960.1 - 0.002 17.6 0.1 0.0043 16.6 0.1 1.5 1 0 0 1 1 1 1 Prolyl oligopeptidase family Esterase_phd PF10503.9 EMD68960.1 - 0.0031 17.0 0.2 0.0084 15.6 0.1 1.6 1 1 0 1 1 1 1 Esterase PHB depolymerase p450 PF00067.22 EMD68962.1 - 6.9e-39 133.9 0.0 2.1e-38 132.3 0.0 1.6 2 0 0 2 2 2 1 Cytochrome P450 CHDNT PF08073.12 EMD68962.1 - 0.12 12.3 0.7 19 5.3 0.0 3.1 3 0 0 3 3 3 0 CHDNT (NUC034) domain Arginase PF00491.21 EMD68963.1 - 2.8e-91 305.9 0.0 3.3e-91 305.7 0.0 1.0 1 0 0 1 1 1 1 Arginase family Fungal_trans_2 PF11951.8 EMD68964.1 - 4.7e-47 160.6 1.4 6.3e-47 160.2 1.4 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD68964.1 - 3.8e-09 36.5 6.6 1.1e-08 35.0 6.6 1.8 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Polysacc_deac_1 PF01522.21 EMD68965.1 - 4.5e-16 58.9 0.0 7.4e-16 58.2 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide deacetylase DUF2334 PF10096.9 EMD68965.1 - 2.6e-05 24.0 0.2 5.1e-05 23.0 0.2 1.5 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2334) DUF2194 PF09960.9 EMD68965.1 - 0.011 14.1 0.0 0.015 13.6 0.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein conserved in bacteria (DUF2194) Na_Ca_ex PF01699.24 EMD68966.1 - 1.1e-32 113.0 31.9 2.6e-18 66.4 8.9 2.0 2 0 0 2 2 2 2 Sodium/calcium exchanger protein YfhO PF09586.10 EMD68966.1 - 4 5.6 5.9 0.83 7.8 0.0 2.3 1 1 1 2 2 2 0 Bacterial membrane protein YfhO CN_hydrolase PF00795.22 EMD68967.1 - 6.2e-45 153.6 0.1 7.8e-45 153.2 0.1 1.1 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Dehydratase_hem PF13816.6 EMD68968.1 - 3.1e-88 296.1 0.5 3.5e-88 296.0 0.5 1.0 1 0 0 1 1 1 1 Haem-containing dehydratase Sdh_cyt PF01127.22 EMD68969.1 - 5.5e-23 81.3 4.1 7e-23 81.0 4.1 1.1 1 0 0 1 1 1 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit p450 PF00067.22 EMD68971.1 - 1.6e-19 70.0 0.0 2.1e-19 69.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 NmrA PF05368.13 EMD68972.1 - 1e-20 74.3 0.1 1.4e-20 73.9 0.1 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EMD68972.1 - 9.8e-13 48.4 0.0 1.8e-12 47.6 0.0 1.4 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EMD68972.1 - 1.2e-10 41.3 0.1 5.6e-08 32.5 0.1 2.1 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family KR PF08659.10 EMD68972.1 - 1.7e-06 28.1 0.1 2.5e-06 27.5 0.1 1.3 1 0 0 1 1 1 1 KR domain 3Beta_HSD PF01073.19 EMD68972.1 - 8e-05 21.8 0.1 0.00013 21.1 0.1 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 EMD68972.1 - 0.0003 20.0 0.4 0.00045 19.5 0.4 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein TrkA_N PF02254.18 EMD68972.1 - 0.001 19.3 0.4 0.0018 18.6 0.4 1.3 1 0 0 1 1 1 1 TrkA-N domain GDP_Man_Dehyd PF16363.5 EMD68972.1 - 0.0014 18.1 0.1 0.018 14.4 0.1 2.0 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase DapB_N PF01113.20 EMD68972.1 - 0.0017 18.4 0.3 0.0043 17.2 0.3 1.7 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus F420_oxidored PF03807.17 EMD68972.1 - 0.002 18.7 1.0 0.011 16.3 1.0 2.1 1 1 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent LpxI_N PF17930.1 EMD68972.1 - 0.004 17.0 0.3 0.045 13.6 0.2 2.1 2 0 0 2 2 2 1 LpxI N-terminal domain NAD_binding_4 PF07993.12 EMD68972.1 - 0.0078 15.4 0.1 0.011 14.9 0.1 1.2 1 0 0 1 1 1 1 Male sterility protein DUF5603 PF18231.1 EMD68972.1 - 0.0089 16.3 0.1 0.024 14.9 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF5603) adh_short PF00106.25 EMD68972.1 - 0.021 14.3 0.3 0.039 13.4 0.3 1.5 1 0 0 1 1 1 0 short chain dehydrogenase Shikimate_DH PF01488.20 EMD68972.1 - 0.031 14.3 0.3 0.059 13.4 0.3 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase RmlD_sub_bind PF04321.17 EMD68972.1 - 0.036 13.2 0.1 0.058 12.5 0.1 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain SBP_bac_3 PF00497.20 EMD68972.1 - 0.088 12.2 0.0 0.17 11.3 0.0 1.5 1 0 0 1 1 1 0 Bacterial extracellular solute-binding proteins, family 3 Amidase PF01425.21 EMD68973.1 - 2.8e-30 105.7 0.1 5e-30 104.9 0.1 1.3 1 0 0 1 1 1 1 Amidase NUDIX PF00293.28 EMD68974.1 - 1.9e-18 66.8 0.3 2.3e-18 66.5 0.3 1.1 1 0 0 1 1 1 1 NUDIX domain ATE_C PF04377.15 EMD68975.1 - 1.8e-47 161.3 1.8 3e-47 160.6 1.8 1.4 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, C terminus ATE_N PF04376.13 EMD68975.1 - 7e-27 93.6 0.4 4.8e-26 91.0 0.4 2.2 2 0 0 2 2 2 1 Arginine-tRNA-protein transferase, N terminus Acetyltransf_6 PF13480.7 EMD68975.1 - 0.29 11.3 3.2 0.44 10.7 1.3 2.2 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Steroid_dh PF02544.16 EMD68976.1 - 9.3e-35 119.8 0.0 1.2e-34 119.4 0.0 1.2 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase PEMT PF04191.13 EMD68976.1 - 1.6e-05 25.3 1.5 7.3e-05 23.1 0.6 2.3 2 1 0 2 2 2 1 Phospholipid methyltransferase DUF1295 PF06966.12 EMD68976.1 - 0.0043 16.6 0.0 0.0066 16.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) An_peroxidase PF03098.15 EMD68977.1 - 8e-37 127.0 0.0 2.3e-25 89.2 0.0 3.2 1 1 1 2 2 2 2 Animal haem peroxidase p450 PF00067.22 EMD68977.1 - 2.4e-09 36.5 0.0 3.1e-07 29.5 0.0 2.2 2 0 0 2 2 2 2 Cytochrome P450 PAD PF03068.15 EMD68980.1 - 2.9e-117 392.0 0.0 3.7e-117 391.6 0.0 1.1 1 0 0 1 1 1 1 Protein-arginine deiminase (PAD) Fungal_trans_2 PF11951.8 EMD68981.1 - 2e-07 30.2 0.1 3e-07 29.6 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD68981.1 - 6.1e-07 29.5 10.7 1.3e-06 28.4 10.7 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MmgE_PrpD PF03972.14 EMD68982.1 - 1.4e-91 307.2 13.5 2.5e-54 184.5 13.2 2.1 1 1 1 2 2 2 2 MmgE/PrpD family BING4CT PF08149.11 EMD68983.1 - 2.6e-37 126.5 0.0 8.1e-34 115.3 0.0 3.4 3 0 0 3 3 3 2 BING4CT (NUC141) domain ANAPC4_WD40 PF12894.7 EMD68983.1 - 0.00059 20.1 0.0 4.9 7.5 0.0 4.5 2 1 3 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EMD68983.1 - 0.004 18.0 0.1 0.071 14.0 0.0 3.1 2 1 1 3 3 3 1 WD domain, G-beta repeat WD40_like PF17005.5 EMD68983.1 - 0.071 12.4 0.0 0.2 11.0 0.0 1.6 1 1 0 1 1 1 0 WD40-like domain RIBIOP_C PF04950.12 EMD68984.1 - 6.7e-109 363.8 0.2 2e-108 362.3 0.0 1.9 3 0 0 3 3 3 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 EMD68984.1 - 1.1e-18 67.1 0.0 2.9e-18 65.7 0.0 1.8 1 0 0 1 1 1 1 AARP2CN (NUC121) domain Stc1 PF12898.7 EMD68985.1 - 3.2e-23 82.1 11.9 7.2e-23 81.0 11.9 1.6 1 0 0 1 1 1 1 Stc1 domain HypA PF01155.19 EMD68985.1 - 0.87 9.6 6.6 1.8 8.6 3.5 2.2 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Ribosomal_L34e PF01199.18 EMD68985.1 - 2.2 8.7 7.8 0.14 12.5 0.9 2.3 2 1 1 3 3 3 0 Ribosomal protein L34e LRR_6 PF13516.6 EMD68986.1 - 1.8e-06 27.5 0.3 4.5 7.6 0.0 5.9 7 0 0 7 7 7 1 Leucine Rich repeat LRR_4 PF12799.7 EMD68986.1 - 0.0015 18.9 0.4 36 5.0 0.0 5.2 5 2 1 6 6 6 0 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EMD68986.1 - 0.0029 17.9 3.3 67 4.6 0.0 6.1 7 1 0 7 7 7 0 Leucine Rich Repeat GATA PF00320.27 EMD68986.1 - 0.022 14.4 0.5 0.053 13.1 0.5 1.6 1 0 0 1 1 1 0 GATA zinc finger CCDC106 PF15794.5 EMD68986.1 - 0.084 12.6 7.4 0.19 11.4 7.4 1.5 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 DUF1699 PF08004.11 EMD68986.1 - 0.2 11.4 1.0 5.2 6.8 0.1 3.5 3 1 1 4 4 4 0 Protein of unknown function (DUF1699) CDC45 PF02724.14 EMD68986.1 - 0.57 8.4 8.1 0.81 7.9 8.1 1.1 1 0 0 1 1 1 0 CDC45-like protein YIF1 PF03878.15 EMD68987.1 - 4.1e-97 324.4 1.5 4.8e-97 324.2 1.5 1.0 1 0 0 1 1 1 1 YIF1 RSN1_7TM PF02714.15 EMD68988.1 - 1.7e-87 293.2 19.0 3.2e-87 292.3 19.0 1.5 1 0 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate SRP-alpha_N PF04086.13 EMD68988.1 - 1.8e-79 267.7 0.2 1.8e-79 267.7 0.2 1.5 2 0 0 2 2 2 1 Signal recognition particle, alpha subunit, N-terminal SRP54 PF00448.22 EMD68988.1 - 3e-38 131.4 0.0 5.6e-38 130.6 0.0 1.4 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain RSN1_TM PF13967.6 EMD68988.1 - 7e-31 107.1 0.2 7e-31 107.1 0.2 3.1 4 0 0 4 4 4 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 EMD68988.1 - 7.6e-29 101.2 1.0 1.8e-28 99.9 1.0 1.7 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter PHM7_ext PF12621.8 EMD68988.1 - 8.5e-20 70.7 0.0 1.7e-19 69.8 0.0 1.5 1 0 0 1 1 1 1 Extracellular tail, of 10TM putative phosphate transporter SRP54_N PF02881.19 EMD68988.1 - 5.2e-08 33.0 1.0 1.7e-07 31.4 0.1 2.4 2 0 0 2 2 2 1 SRP54-type protein, helical bundle domain MeaB PF03308.16 EMD68988.1 - 3.6e-06 26.2 0.0 6.7e-06 25.3 0.0 1.4 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_30 PF13604.6 EMD68988.1 - 0.011 15.5 0.0 0.022 14.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EMD68988.1 - 0.059 13.8 0.0 0.15 12.4 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.27 EMD68988.1 - 0.067 13.7 0.0 0.23 12.0 0.0 2.0 1 0 0 1 1 1 0 ABC transporter AAA_17 PF13207.6 EMD68988.1 - 0.12 12.8 0.0 0.42 11.0 0.0 2.0 1 0 0 1 1 1 0 AAA domain Peptidase_S10 PF00450.22 EMD68990.1 - 2.2e-78 264.6 0.1 2.8e-78 264.2 0.1 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase DUF4428 PF14471.6 EMD68992.1 - 0.011 15.6 1.6 6.7 6.7 0.1 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4428) Trp_syntA PF00290.20 EMD68993.1 - 1.2e-94 316.0 0.0 2.2e-94 315.2 0.0 1.4 1 0 0 1 1 1 1 Tryptophan synthase alpha chain PALP PF00291.25 EMD68993.1 - 1.2e-44 152.9 2.1 1.2e-44 152.9 2.1 1.6 2 0 0 2 2 2 1 Pyridoxal-phosphate dependent enzyme SPX PF03105.19 EMD68993.1 - 8.9e-39 134.5 9.8 1.2e-25 91.3 6.7 2.2 1 1 1 2 2 2 2 SPX domain Na_sulph_symp PF00939.19 EMD68993.1 - 1.6e-32 113.2 43.8 2.6e-32 112.5 43.8 1.3 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 EMD68993.1 - 2.2e-28 99.4 68.1 1.8e-25 89.8 40.7 3.1 1 1 2 3 3 3 2 Citrate transporter FAM76 PF16046.5 EMD68993.1 - 4.4 6.6 4.6 0.84 8.9 0.5 1.7 2 0 0 2 2 2 0 FAM76 protein Myc_N PF01056.18 EMD68994.1 - 0.0036 17.3 1.6 0.0042 17.0 1.6 1.1 1 0 0 1 1 1 1 Myc amino-terminal region RNA_pol_3_Rpc31 PF11705.8 EMD68994.1 - 0.022 15.0 1.8 0.026 14.8 1.8 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 BHD_2 PF10404.9 EMD68994.1 - 2 9.5 4.9 3.9 8.5 4.9 1.6 1 1 0 1 1 1 0 Rad4 beta-hairpin domain 2 Tetraspanin PF00335.20 EMD68995.1 - 3e-05 23.9 0.8 7.7e-05 22.5 0.8 1.8 1 1 0 1 1 1 1 Tetraspanin family Ribosomal_L18p PF00861.22 EMD68995.1 - 0.031 14.6 0.0 0.086 13.2 0.0 1.7 1 0 0 1 1 1 0 Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast FAD_binding_2 PF00890.24 EMD68997.1 - 9.5e-117 390.6 7.5 9.5e-117 390.6 7.5 1.7 2 0 0 2 2 2 1 FAD binding domain Succ_DH_flav_C PF02910.20 EMD68997.1 - 1.2e-39 135.2 2.6 2.1e-39 134.4 2.6 1.4 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term Pyr_redox_2 PF07992.14 EMD68997.1 - 5.3e-05 22.6 1.9 0.0029 16.9 0.6 2.7 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EMD68997.1 - 0.0031 16.6 3.3 0.3 10.1 3.3 2.3 2 0 0 2 2 2 1 Glucose inhibited division protein A FAD_binding_3 PF01494.19 EMD68997.1 - 0.0065 15.8 0.7 0.014 14.6 0.7 1.5 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 EMD68997.1 - 0.014 14.6 0.7 0.86 8.8 0.3 2.3 2 0 0 2 2 2 0 Thi4 family Lycopene_cycl PF05834.12 EMD68997.1 - 0.015 14.4 0.1 0.023 13.8 0.1 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein DAO PF01266.24 EMD68997.1 - 0.023 14.3 0.8 0.1 12.2 0.8 1.9 1 1 0 1 1 1 0 FAD dependent oxidoreductase HI0933_like PF03486.14 EMD68997.1 - 0.16 10.6 3.2 1.4 7.5 0.4 3.2 4 0 0 4 4 4 0 HI0933-like protein Pyr_redox_3 PF13738.6 EMD68997.1 - 1.2 8.3 3.3 1.2 8.4 1.4 1.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase ETX_MTX2 PF03318.13 EMD68998.1 - 0.0044 16.8 11.9 0.0065 16.3 9.6 2.1 2 0 0 2 2 2 1 Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2 Pro_dh PF01619.18 EMD68999.1 - 2.1e-61 208.0 0.0 2.6e-61 207.7 0.0 1.1 1 0 0 1 1 1 1 Proline dehydrogenase AP_endonuc_2 PF01261.24 EMD68999.1 - 0.022 14.2 0.0 0.062 12.7 0.0 1.8 1 1 0 1 1 1 0 Xylose isomerase-like TIM barrel P5CR_dimer PF14748.6 EMD69000.1 - 1.9e-28 98.7 3.6 3.2e-28 98.0 3.6 1.4 1 0 0 1 1 1 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.17 EMD69000.1 - 1.3e-06 28.9 0.0 3e-05 24.5 0.0 2.5 1 1 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Cyclin PF08613.11 EMD69001.1 - 9.3e-06 26.1 4.9 1.4e-05 25.5 0.0 2.4 2 0 0 2 2 2 1 Cyclin Cyclin_N PF00134.23 EMD69001.1 - 0.0044 16.7 0.0 0.0094 15.7 0.0 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain SnoaL PF07366.12 EMD69003.1 - 0.00013 21.7 0.0 0.0003 20.6 0.0 1.7 1 0 0 1 1 1 1 SnoaL-like polyketide cyclase SnoaL_2 PF12680.7 EMD69003.1 - 0.016 15.9 0.1 0.072 13.7 0.1 2.1 1 1 1 2 2 2 0 SnoaL-like domain PIP5K PF01504.18 EMD69004.1 - 7.8e-44 150.0 0.0 9.5e-43 146.4 0.0 2.0 1 1 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase Rick_17kDa_Anti PF05433.15 EMD69005.1 - 0.0041 16.9 16.3 0.0061 16.4 16.3 1.3 1 0 0 1 1 1 1 Glycine zipper 2TM domain DUF533 PF04391.12 EMD69005.1 - 0.14 11.7 0.3 0.29 10.7 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF533) DNA_methylase PF00145.17 EMD69009.1 - 1.8e-37 129.5 0.0 3.9e-23 82.3 0.0 2.8 1 1 1 3 3 3 3 C-5 cytosine-specific DNA methylase DUF1690 PF07956.11 EMD69010.1 - 6.9e-34 117.3 15.1 3.2e-33 115.1 15.1 1.8 1 1 0 1 1 1 1 Protein of Unknown function (DUF1690) Rootletin PF15035.6 EMD69010.1 - 0.0014 18.7 13.9 0.0029 17.7 13.9 1.5 1 1 0 1 1 1 1 Ciliary rootlet component, centrosome cohesion DUF4240 PF14024.6 EMD69010.1 - 0.035 14.3 2.2 0.044 14.0 0.3 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF4240) Prominin PF05478.11 EMD69010.1 - 0.048 11.6 2.8 0.054 11.5 2.8 1.0 1 0 0 1 1 1 0 Prominin DUF3801 PF12687.7 EMD69010.1 - 0.19 11.8 7.7 0.3 11.1 7.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3801) FmiP_Thoc5 PF09766.9 EMD69010.1 - 0.23 10.7 11.4 0.32 10.2 11.3 1.3 1 1 0 1 1 1 0 Fms-interacting protein/Thoc5 Tup_N PF08581.10 EMD69010.1 - 0.3 11.4 8.6 0.94 9.8 6.4 2.7 2 1 1 3 3 3 0 Tup N-terminal APG6_N PF17675.1 EMD69010.1 - 0.4 11.2 17.2 3.9 8.0 16.3 2.4 1 1 1 2 2 2 0 Apg6 coiled-coil region PepSY_TM_like_2 PF16357.5 EMD69010.1 - 0.59 10.1 2.2 0.83 9.6 2.2 1.2 1 0 0 1 1 1 0 Putative PepSY_TM-like Fez1 PF06818.15 EMD69010.1 - 1.5 9.2 15.3 1.6 9.1 14.0 1.6 1 1 0 1 1 1 0 Fez1 Bap31_Bap29_C PF18035.1 EMD69010.1 - 2.6 8.1 10.8 0.83 9.7 3.0 2.9 2 1 0 2 2 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain DUF4407 PF14362.6 EMD69010.1 - 4 6.7 9.3 5.4 6.3 9.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) CBM_1 PF00734.18 EMD69011.1 - 3.3e-09 36.5 12.8 7.6e-09 35.4 12.8 1.7 1 0 0 1 1 1 1 Fungal cellulose binding domain Acetyltransf_1 PF00583.25 EMD69011.1 - 9.8e-08 32.2 0.0 1.5e-07 31.6 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EMD69011.1 - 0.0011 18.9 0.0 0.0017 18.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EMD69011.1 - 0.018 15.5 0.0 0.031 14.7 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 EMD69011.1 - 0.071 13.2 0.0 0.11 12.6 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Dicty_REP PF05086.12 EMD69011.1 - 3.5 5.5 4.0 4.8 5.0 4.0 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein His_Phos_1 PF00300.22 EMD69012.1 - 4.1e-36 124.5 0.8 7.1e-35 120.5 0.8 2.0 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) zf-C2H2 PF00096.26 EMD69013.1 - 5.6e-15 54.9 31.9 0.0029 18.0 0.1 6.6 6 0 0 6 6 6 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMD69013.1 - 6.6e-14 51.4 27.2 0.0036 18.0 0.2 6.7 6 0 0 6 6 6 6 C2H2-type zinc finger zf-met PF12874.7 EMD69013.1 - 3.7e-09 36.7 19.8 0.0059 17.0 0.7 6.4 6 0 0 6 6 6 4 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EMD69013.1 - 1.2e-06 28.6 29.5 0.1 12.9 0.5 6.4 6 0 0 6 6 6 3 Zinc-finger double-stranded RNA-binding zf_UBZ PF18439.1 EMD69013.1 - 0.00087 18.8 11.4 0.61 9.7 0.1 5.0 4 0 0 4 4 4 2 Ubiquitin-Binding Zinc Finger zf-C2H2_6 PF13912.6 EMD69013.1 - 0.047 13.7 23.5 5.7 7.1 1.2 6.3 6 0 0 6 6 6 0 C2H2-type zinc finger HypA PF01155.19 EMD69013.1 - 1 9.4 9.5 14 5.8 0.0 3.9 3 1 0 4 4 4 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA C1_1 PF00130.22 EMD69013.1 - 1.3 9.0 14.5 4.2 7.3 0.6 4.3 2 1 2 4 4 4 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zinc-ribbons_6 PF07191.12 EMD69013.1 - 1.4 9.0 14.6 10 6.2 1.6 4.1 3 1 0 3 3 3 0 zinc-ribbons zf-C2H2_11 PF16622.5 EMD69013.1 - 1.8 8.4 10.8 5.4 6.9 0.3 4.5 5 0 0 5 5 5 0 zinc-finger C2H2-type CK_II_beta PF01214.18 EMD69013.1 - 2.5 7.9 5.1 3.7 7.3 1.0 2.8 2 1 1 3 3 3 0 Casein kinase II regulatory subunit zf-Di19 PF05605.12 EMD69013.1 - 9.6 6.6 9.5 0.61 10.4 2.2 2.9 4 0 0 4 4 4 0 Drought induced 19 protein (Di19), zinc-binding MFS_1 PF07690.16 EMD69014.1 - 4.6e-27 94.9 15.0 4.6e-27 94.9 15.0 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 EMD69014.1 - 6.1e-06 24.9 3.0 9.6e-06 24.3 3.0 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) NAD_binding_6 PF08030.12 EMD69015.1 - 6.7e-20 71.8 0.0 4.3e-19 69.1 0.0 2.1 1 1 0 1 1 1 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.19 EMD69015.1 - 2.8e-19 69.5 7.0 7.5e-19 68.1 7.0 1.8 1 0 0 1 1 1 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 EMD69015.1 - 1.8e-13 50.5 0.0 4.5e-13 49.2 0.0 1.7 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_1 PF00175.21 EMD69015.1 - 0.00014 22.4 0.0 0.081 13.6 0.0 2.5 2 0 0 2 2 2 2 Oxidoreductase NAD-binding domain DUF4405 PF14358.6 EMD69015.1 - 5.6 7.6 14.7 0.61 10.7 1.8 3.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4405) Sporozoite_P67 PF05642.11 EMD69016.1 - 2.5 6.1 5.7 2.8 5.9 5.7 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen BORCS6 PF10157.9 EMD69017.1 - 0.019 15.2 0.0 0.024 14.9 0.0 1.1 1 0 0 1 1 1 0 BLOC-1-related complex sub-unit 6 MmgE_PrpD PF03972.14 EMD69020.1 - 8.5e-146 485.9 0.0 1.1e-145 485.6 0.0 1.0 1 0 0 1 1 1 1 MmgE/PrpD family WH1 PF00568.23 EMD69021.1 - 5.5e-28 97.1 0.0 7.8e-28 96.6 0.0 1.2 1 0 0 1 1 1 1 WH1 domain WH2 PF02205.20 EMD69021.1 - 5e-07 29.4 0.4 1.1e-06 28.2 0.4 1.6 1 0 0 1 1 1 1 WH2 motif Zn_clus PF00172.18 EMD69022.1 - 2.7e-07 30.6 8.8 4.5e-07 29.9 8.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 EMD69022.1 - 0.001 18.0 0.2 0.0015 17.4 0.2 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Glyco_transf_15 PF01793.16 EMD69023.1 - 4.6e-98 328.4 0.9 8.6e-98 327.6 0.9 1.2 1 1 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase adh_short PF00106.25 EMD69024.1 - 1.4e-35 122.6 0.0 1.9e-35 122.1 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD69024.1 - 1.6e-22 80.2 0.0 2.1e-22 79.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF1776 PF08643.10 EMD69024.1 - 0.013 14.9 0.0 0.089 12.1 0.0 1.9 2 0 0 2 2 2 0 Fungal family of unknown function (DUF1776) SbcD_C PF12320.8 EMD69024.1 - 0.2 12.0 0.0 0.34 11.2 0.0 1.3 1 0 0 1 1 1 0 Type 5 capsule protein repressor C-terminal domain Methyltransf_23 PF13489.6 EMD69025.1 - 6.7e-15 55.3 0.0 8.8e-15 54.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMD69025.1 - 3.5e-08 34.0 0.0 3.1e-07 30.9 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMD69025.1 - 1e-06 28.6 0.0 6.1e-06 26.1 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMD69025.1 - 7.1e-06 26.6 0.0 0.00031 21.4 0.0 2.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMD69025.1 - 8.4e-06 26.5 0.0 2.8e-05 24.8 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain DUF5606 PF18347.1 EMD69025.1 - 0.016 15.3 0.5 2.4 8.4 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF5606) Ubie_methyltran PF01209.18 EMD69025.1 - 0.096 12.0 0.0 0.32 10.3 0.0 1.8 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family Ribosomal_L37ae PF01780.19 EMD69027.1 - 2.5e-41 139.7 10.0 2.8e-41 139.5 10.0 1.0 1 0 0 1 1 1 1 Ribosomal L37ae protein family zf-RING_13 PF17977.1 EMD69027.1 - 0.0011 19.0 1.3 0.0016 18.5 1.3 1.2 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain Ima1_N PF09779.9 EMD69027.1 - 0.011 16.6 0.2 0.015 16.2 0.2 1.3 1 0 0 1 1 1 0 Ima1 N-terminal domain Zn_Tnp_IS1595 PF12760.7 EMD69027.1 - 0.02 14.9 3.3 0.035 14.1 3.3 1.4 1 0 0 1 1 1 0 Transposase zinc-ribbon domain GFA PF04828.14 EMD69027.1 - 0.03 14.6 4.4 0.36 11.2 0.4 2.1 1 1 1 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme zf-BED PF02892.15 EMD69027.1 - 0.036 14.1 5.7 0.32 11.1 0.5 2.2 1 1 1 2 2 2 0 BED zinc finger DUF1451 PF07295.11 EMD69027.1 - 0.044 13.8 0.7 0.059 13.4 0.7 1.2 1 0 0 1 1 1 0 Zinc-ribbon containing domain A2L_zn_ribbon PF08792.10 EMD69027.1 - 0.052 13.3 3.1 0.095 12.4 0.1 2.1 2 0 0 2 2 2 0 A2L zinc ribbon domain CarbpepA_inh PF02977.15 EMD69027.1 - 0.08 12.7 4.8 0.14 11.9 0.3 2.2 1 1 1 2 2 2 0 Carboxypeptidase A inhibitor zf-H2C2_2 PF13465.6 EMD69027.1 - 0.11 13.0 2.8 5.5 7.6 0.4 2.3 1 1 1 2 2 2 0 Zinc-finger double domain C1_2 PF03107.16 EMD69027.1 - 0.2 12.0 2.2 1 9.8 2.3 1.8 1 1 1 2 2 2 0 C1 domain Rubredoxin_2 PF18073.1 EMD69027.1 - 1.4 8.7 8.1 8.3 6.2 8.1 2.0 1 1 0 1 1 1 0 Rubredoxin metal binding domain MFS_1 PF07690.16 EMD69028.1 - 3.8e-34 118.2 33.9 5.3e-34 117.7 24.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily PetM PF08041.11 EMD69028.1 - 0.0055 16.3 2.0 0.022 14.4 2.0 2.1 1 0 0 1 1 1 1 PetM family of cytochrome b6f complex subunit 7 DUF3522 PF12036.8 EMD69028.1 - 0.3 11.3 6.2 0.72 10.1 0.1 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF3522) ABC2_membrane PF01061.24 EMD69029.1 - 8.1e-84 280.2 62.9 8.7e-44 149.5 27.7 2.6 3 0 0 3 3 2 2 ABC-2 type transporter ABC_tran PF00005.27 EMD69029.1 - 2.9e-37 128.2 0.0 1.8e-16 60.9 0.0 3.4 3 0 0 3 3 3 2 ABC transporter PDR_CDR PF06422.12 EMD69029.1 - 2.4e-35 120.3 0.8 9.2e-33 112.0 0.0 4.0 4 0 0 4 4 3 2 CDR ABC transporter ABC_trans_N PF14510.6 EMD69029.1 - 2.9e-17 63.0 0.1 8.1e-17 61.6 0.1 1.8 1 0 0 1 1 1 1 ABC-transporter N-terminal RsgA_GTPase PF03193.16 EMD69029.1 - 1.4e-07 31.5 0.1 0.00034 20.6 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 EMD69029.1 - 1.1e-06 29.1 0.2 0.0042 17.5 0.2 2.5 2 0 0 2 2 2 2 AAA ATPase domain ABC2_membrane_3 PF12698.7 EMD69029.1 - 2.5e-06 26.8 44.3 0.00052 19.2 22.2 2.7 2 1 0 2 2 2 2 ABC-2 family transporter protein AAA_25 PF13481.6 EMD69029.1 - 1.6e-05 24.6 0.1 0.00066 19.3 0.0 2.5 3 0 0 3 3 2 1 AAA domain AAA_33 PF13671.6 EMD69029.1 - 5.2e-05 23.4 0.1 0.019 15.1 0.0 2.6 2 0 0 2 2 2 1 AAA domain SMC_N PF02463.19 EMD69029.1 - 0.00033 20.1 0.0 0.12 11.7 0.0 3.5 3 1 0 3 3 3 1 RecF/RecN/SMC N terminal domain AAA_18 PF13238.6 EMD69029.1 - 0.00039 21.0 0.1 0.052 14.1 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_21 PF13304.6 EMD69029.1 - 0.00039 20.3 0.0 0.7 9.7 0.0 2.5 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EMD69029.1 - 0.001 18.7 1.3 0.051 13.3 0.1 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_22 PF13401.6 EMD69029.1 - 0.0031 17.8 0.5 2.2 8.5 0.1 2.5 2 0 0 2 2 2 1 AAA domain cobW PF02492.19 EMD69029.1 - 0.012 15.2 0.7 0.38 10.3 0.1 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Rad17 PF03215.15 EMD69029.1 - 0.02 14.8 0.0 1.2 9.0 0.0 2.4 2 0 0 2 2 2 0 Rad17 P-loop domain AAA_30 PF13604.6 EMD69029.1 - 0.036 13.8 0.7 2.7 7.6 0.2 2.3 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 EMD69029.1 - 0.037 14.1 0.2 5.7 7.1 0.0 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_28 PF13521.6 EMD69029.1 - 0.054 13.7 0.4 3.1 8.0 0.1 2.6 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.6 EMD69029.1 - 0.071 13.5 0.3 1.9 8.9 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 EMD69029.1 - 0.072 12.8 0.3 15 5.3 0.1 2.4 2 0 0 2 2 2 0 AAA domain Ploopntkinase3 PF18751.1 EMD69029.1 - 0.095 12.6 0.1 0.88 9.5 0.0 2.4 3 0 0 3 3 2 0 P-loop Nucleotide Kinase3 AAA_23 PF13476.6 EMD69029.1 - 0.14 12.6 0.1 1.9 8.9 0.0 2.4 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 EMD69029.1 - 4.6 7.1 4.7 3.9 7.4 0.3 2.6 3 0 0 3 3 2 0 NACHT domain Zn_clus PF00172.18 EMD69031.1 - 2.8e-05 24.1 13.8 2.8e-05 24.1 13.8 2.3 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PepSY_2 PF13670.6 EMD69032.1 - 0.063 13.3 0.2 1.3 9.1 0.3 2.0 1 1 1 2 2 2 0 Peptidase propeptide and YPEB domain zf-CCHC PF00098.23 EMD69033.1 - 0.017 15.2 2.7 0.03 14.4 2.7 1.4 1 0 0 1 1 1 0 Zinc knuckle Aldo_ket_red PF00248.21 EMD69034.1 - 9.7e-70 235.1 0.0 1.1e-69 234.9 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family p450 PF00067.22 EMD69037.1 - 5.9e-62 209.9 0.0 7.5e-62 209.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 TRI5 PF06330.11 EMD69038.1 - 8.7e-17 61.0 0.1 1.1e-16 60.7 0.1 1.1 1 0 0 1 1 1 1 Trichodiene synthase (TRI5) p450 PF00067.22 EMD69040.1 - 1.1e-17 64.0 0.0 2.7e-09 36.3 0.1 2.2 2 0 0 2 2 2 2 Cytochrome P450 polyprenyl_synt PF00348.17 EMD69041.1 - 1.9e-49 168.0 0.1 6.7e-49 166.3 0.0 1.9 2 0 0 2 2 2 1 Polyprenyl synthetase Terpene_synth_C PF03936.16 EMD69041.1 - 2e-07 30.6 0.1 2.7e-05 23.6 0.0 2.6 2 0 0 2 2 2 2 Terpene synthase family, metal binding domain MafB PF06255.13 EMD69041.1 - 0.0062 16.0 0.0 0.0099 15.3 0.0 1.2 1 0 0 1 1 1 1 Neisseria toxin MafB ANTAR PF03861.14 EMD69041.1 - 0.022 14.6 0.1 0.05 13.4 0.1 1.5 1 0 0 1 1 1 0 ANTAR domain DUF465 PF04325.13 EMD69041.1 - 0.17 12.0 2.8 1.1 9.3 0.1 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF465) DMT_YdcZ PF04657.13 EMD69042.1 - 0.018 15.3 0.0 0.019 15.2 0.0 1.0 1 0 0 1 1 1 0 Putative inner membrane exporter, YdcZ DUF755 PF05501.11 EMD69043.1 - 0.038 14.3 0.1 0.041 14.1 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF755) CorA PF01544.18 EMD69046.1 - 5.6e-11 42.3 1.2 8.5e-11 41.7 1.2 1.3 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein DDE_Tnp_ISL3 PF01610.17 EMD69046.1 - 0.029 14.1 0.2 0.044 13.5 0.2 1.2 1 0 0 1 1 1 0 Transposase DUF2274 PF10038.9 EMD69046.1 - 0.086 13.3 1.0 0.19 12.2 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2274) DNA_pol3_delta2 PF13177.6 EMD69047.1 - 1.9e-10 40.8 0.1 5.2e-10 39.3 0.1 1.7 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA PF00004.29 EMD69047.1 - 4.5e-06 27.1 0.5 1.2e-05 25.7 0.1 1.9 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EMD69047.1 - 2.1e-05 24.8 0.8 0.0015 18.8 0.1 2.6 2 2 0 2 2 2 1 AAA domain Rep_fac_C PF08542.11 EMD69047.1 - 0.00013 22.3 0.2 0.0005 20.4 0.0 2.0 2 0 0 2 2 2 1 Replication factor C C-terminal domain AAA_16 PF13191.6 EMD69047.1 - 0.00038 20.9 0.9 0.0063 16.9 0.2 2.7 2 1 0 2 2 2 1 AAA ATPase domain AAA_24 PF13479.6 EMD69047.1 - 0.00097 18.9 1.1 0.02 14.6 0.3 2.5 2 1 0 2 2 2 1 AAA domain Rad17 PF03215.15 EMD69047.1 - 0.0067 16.4 0.0 0.027 14.4 0.0 1.9 2 0 0 2 2 2 1 Rad17 P-loop domain ABC_tran PF00005.27 EMD69047.1 - 0.017 15.7 0.0 0.06 13.9 0.0 2.0 1 1 0 1 1 1 0 ABC transporter DNA_pol3_delta PF06144.13 EMD69047.1 - 0.021 14.6 0.1 0.04 13.7 0.1 1.4 1 0 0 1 1 1 0 DNA polymerase III, delta subunit T4SS-DNA_transf PF02534.14 EMD69047.1 - 0.11 11.3 0.0 0.19 10.5 0.0 1.3 1 0 0 1 1 1 0 Type IV secretory system Conjugative DNA transfer AAA_5 PF07728.14 EMD69047.1 - 0.14 12.2 0.3 0.39 10.7 0.3 1.8 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) Aldedh PF00171.22 EMD69048.1 - 1.5e-118 396.3 0.0 1.8e-118 396.0 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family adh_short_C2 PF13561.6 EMD69049.1 - 3e-56 190.6 0.2 3.4e-56 190.4 0.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EMD69049.1 - 8e-40 136.4 0.2 9.5e-40 136.1 0.2 1.0 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EMD69049.1 - 4.7e-09 36.4 0.6 6.8e-09 35.9 0.6 1.2 1 0 0 1 1 1 1 KR domain 3HCDH_N PF02737.18 EMD69049.1 - 9.6e-05 22.3 0.1 0.00021 21.2 0.1 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ChuX_HutX PF06228.13 EMD69049.1 - 0.0032 17.2 0.3 0.38 10.5 0.1 2.3 1 1 0 2 2 2 2 Haem utilisation ChuX/HutX Methyltransf_25 PF13649.6 EMD69049.1 - 0.016 15.9 0.0 0.032 14.9 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain UDPG_MGDP_dh_N PF03721.14 EMD69049.1 - 0.036 13.7 0.5 0.11 12.1 0.1 1.9 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Methyltransf_12 PF08242.12 EMD69049.1 - 0.067 13.9 0.0 0.14 12.9 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain Gln-synt_C PF00120.24 EMD69050.1 - 5.7e-86 288.6 0.0 7e-86 288.3 0.0 1.1 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain Rpr2 PF04032.16 EMD69051.1 - 1.6e-23 82.8 0.1 2.6e-23 82.1 0.1 1.3 1 0 0 1 1 1 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain HNH_5 PF14279.6 EMD69051.1 - 0.027 14.3 2.5 1.7 8.5 0.1 2.3 1 1 0 2 2 2 0 HNH endonuclease DEAD PF00270.29 EMD69052.1 - 8e-38 129.9 0.0 1.3e-37 129.3 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EMD69052.1 - 3e-25 88.7 0.2 1.5e-23 83.2 0.1 2.5 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EMD69052.1 - 8.5e-09 35.6 0.0 1.9e-08 34.5 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 EMD69052.1 - 0.0015 18.0 0.0 0.0041 16.5 0.0 1.7 2 0 0 2 2 2 1 U3-containing 90S pre-ribosomal complex subunit DUF4844 PF16133.5 EMD69052.1 - 0.032 14.8 0.8 0.078 13.5 0.8 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4844) DEFB136 PF17333.2 EMD69053.1 - 0.42 10.6 5.5 0.22 11.5 2.7 1.9 3 0 0 3 3 3 0 Beta defensin 136 ApbA PF02558.16 EMD69055.1 - 1.3e-25 89.9 0.0 3.1e-25 88.6 0.0 1.6 2 0 0 2 2 2 1 Ketopantoate reductase PanE/ApbA ApbA_C PF08546.11 EMD69055.1 - 6.3e-23 81.3 0.0 9.3e-23 80.8 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal Hexokinase_2 PF03727.16 EMD69056.1 - 4.2e-77 258.8 0.0 5.7e-77 258.4 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 EMD69056.1 - 9.6e-75 250.9 0.1 1.4e-74 250.3 0.1 1.3 1 0 0 1 1 1 1 Hexokinase DUF5610 PF18433.1 EMD69056.1 - 0.018 15.5 0.1 0.043 14.3 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5610) zf-HIT PF04438.16 EMD69058.1 - 1.8e-11 43.7 10.1 2.5e-11 43.2 10.1 1.2 1 0 0 1 1 1 1 HIT zinc finger DUF5320 PF17253.2 EMD69058.1 - 0.0061 17.6 1.5 0.011 16.8 1.5 1.4 1 0 0 1 1 1 1 Family of unknown function (DUF5320) zf-MYND PF01753.18 EMD69058.1 - 0.0079 16.3 6.7 0.012 15.7 6.7 1.3 1 0 0 1 1 1 1 MYND finger PRIMA1 PF16101.5 EMD69058.1 - 0.034 14.2 3.2 0.052 13.6 3.2 1.3 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 zf-B_box PF00643.24 EMD69058.1 - 0.14 12.3 6.3 0.21 11.8 6.3 1.2 1 0 0 1 1 1 0 B-box zinc finger zf-C6H2 PF15801.5 EMD69058.1 - 0.3 11.4 8.6 0.62 10.4 8.6 1.5 1 0 0 1 1 1 0 zf-MYND-like zinc finger, mRNA-binding zf-Mss51 PF13824.6 EMD69058.1 - 1.3 9.2 5.3 2.7 8.2 5.3 1.5 1 0 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 CtaG_Cox11 PF04442.14 EMD69059.1 - 2.8e-60 202.7 0.1 4.8e-60 202.0 0.0 1.4 2 0 0 2 2 2 1 Cytochrome c oxidase assembly protein CtaG/Cox11 DnaJ PF00226.31 EMD69060.1 - 1.8e-20 72.8 0.8 3.6e-20 71.8 0.8 1.5 1 0 0 1 1 1 1 DnaJ domain NmrA PF05368.13 EMD69061.1 - 1.5e-30 106.5 1.0 1.9e-30 106.2 1.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EMD69061.1 - 5.6e-17 62.2 0.0 1.1e-16 61.2 0.0 1.6 1 1 1 2 2 2 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 EMD69061.1 - 1.9e-08 34.6 0.4 3.8e-06 27.2 0.0 2.2 2 0 0 2 2 2 2 Saccharopine dehydrogenase NADP binding domain Epimerase PF01370.21 EMD69061.1 - 0.00011 21.8 0.0 0.00063 19.3 0.0 2.1 1 1 1 2 2 2 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EMD69061.1 - 0.049 12.6 0.1 0.12 11.4 0.0 1.7 2 0 0 2 2 2 0 3-beta hydroxysteroid dehydrogenase/isomerase family DapB_N PF01113.20 EMD69061.1 - 0.092 12.9 1.0 0.2 11.7 0.0 2.0 2 0 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus DUF4985 PF16373.5 EMD69061.1 - 0.13 12.7 0.2 1.2 9.6 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function PAPA-1 PF04795.12 EMD69062.1 - 2.3e-29 102.0 4.7 2.3e-29 102.0 4.7 3.7 3 1 0 3 3 3 1 PAPA-1-like conserved region ADH_N PF08240.12 EMD69063.1 - 9e-25 86.7 5.4 1.4e-24 86.1 5.4 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EMD69063.1 - 6.7e-12 45.5 0.0 3e-11 43.4 0.0 2.1 2 0 0 2 2 2 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 EMD69063.1 - 0.056 12.8 0.1 0.1 12.0 0.1 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ADH_N PF08240.12 EMD69064.1 - 1.9e-29 101.7 0.3 4.5e-29 100.5 0.3 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EMD69064.1 - 2.9e-28 98.4 0.1 4.7e-28 97.8 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EMD69064.1 - 6.5e-09 35.6 0.0 9.2e-09 35.1 0.0 1.2 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus NAD_binding_7 PF13241.6 EMD69064.1 - 0.00024 21.5 0.1 0.00041 20.7 0.1 1.3 1 0 0 1 1 1 1 Putative NAD(P)-binding ADH_zinc_N_2 PF13602.6 EMD69064.1 - 0.00035 21.6 0.0 0.00064 20.8 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase TrkA_N PF02254.18 EMD69064.1 - 0.091 13.0 0.1 0.35 11.1 0.0 1.9 1 1 1 2 2 2 0 TrkA-N domain Shikimate_DH PF01488.20 EMD69064.1 - 0.15 12.1 0.0 0.26 11.3 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase NUDIX PF00293.28 EMD69065.1 - 2.9e-13 50.0 0.2 7.5e-12 45.4 0.1 2.2 1 1 1 2 2 2 2 NUDIX domain p450 PF00067.22 EMD69066.1 - 1.8e-67 228.1 0.0 2.4e-67 227.7 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Lipase_GDSL_2 PF13472.6 EMD69067.1 - 1.1e-14 55.3 0.3 1.6e-14 54.7 0.3 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EMD69067.1 - 1.3e-05 25.3 0.2 2.3e-05 24.5 0.2 1.4 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase RsbRD_N PF14361.6 EMD69067.1 - 0.08 13.6 0.0 1.4 9.7 0.0 2.2 1 1 1 2 2 2 0 RsbT co-antagonist protein rsbRD N-terminal domain Ank_2 PF12796.7 EMD69069.1 - 5.6e-27 94.2 14.9 3.4e-06 27.6 0.0 10.7 7 2 5 13 13 13 8 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMD69069.1 - 1.2e-13 51.3 12.2 0.067 13.8 0.0 10.7 10 1 1 11 11 11 4 Ankyrin repeats (many copies) Ank PF00023.30 EMD69069.1 - 2.6e-10 40.3 20.9 0.11 12.9 0.0 12.7 15 0 0 15 15 15 2 Ankyrin repeat Ank_3 PF13606.6 EMD69069.1 - 2.9e-08 33.3 14.2 1 10.1 0.0 12.0 14 0 0 14 14 14 1 Ankyrin repeat Ank_5 PF13857.6 EMD69069.1 - 9e-06 25.9 11.8 0.16 12.3 0.0 7.9 9 0 0 9 9 9 2 Ankyrin repeats (many copies) DUF3455 PF11937.8 EMD69071.1 - 2.3e-41 141.8 1.4 2.6e-41 141.6 1.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3455) Jacalin PF01419.17 EMD69072.1 - 4.5e-05 23.4 0.0 8.2e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 Jacalin-like lectin domain Exo_endo_phos PF03372.23 EMD69072.1 - 0.011 15.3 0.0 0.029 13.9 0.0 1.8 1 1 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family 4HBT PF03061.22 EMD69073.1 - 0.00019 21.7 0.2 0.00096 19.5 0.2 2.0 1 1 0 1 1 1 1 Thioesterase superfamily NACHT PF05729.12 EMD69074.1 - 1.5e-08 34.7 0.1 3.6e-08 33.5 0.1 1.6 1 0 0 1 1 1 1 NACHT domain Ank_2 PF12796.7 EMD69074.1 - 1.5e-05 25.5 0.0 0.00011 22.7 0.0 2.5 3 1 1 4 4 4 1 Ankyrin repeats (3 copies) AAA_22 PF13401.6 EMD69074.1 - 1.5e-05 25.3 0.0 4.1e-05 23.9 0.0 1.8 1 0 0 1 1 1 1 AAA domain Ank_4 PF13637.6 EMD69074.1 - 0.00056 20.4 0.0 0.0058 17.2 0.0 2.6 2 0 0 2 2 2 1 Ankyrin repeats (many copies) DUF2075 PF09848.9 EMD69074.1 - 0.0038 16.5 0.0 0.025 13.8 0.0 2.1 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA PF00004.29 EMD69074.1 - 0.016 15.7 0.1 0.16 12.4 0.1 2.5 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) VPS28 PF03997.12 EMD69074.1 - 0.037 13.7 0.3 7.6 6.2 0.0 3.1 3 1 0 3 3 3 0 VPS28 protein Ank_5 PF13857.6 EMD69074.1 - 0.048 14.0 0.0 0.15 12.4 0.0 1.9 2 0 0 2 2 2 0 Ankyrin repeats (many copies) AAA_19 PF13245.6 EMD69074.1 - 0.13 12.6 0.0 0.34 11.3 0.0 1.9 1 1 0 1 1 1 0 AAA domain FBA_2 PF07735.17 EMD69074.1 - 5.3 7.2 5.3 6 7.1 0.1 3.1 3 1 1 4 4 4 0 F-box associated His_Phos_2 PF00328.22 EMD69075.1 - 1.3e-39 136.7 0.0 1.5e-39 136.5 0.0 1.0 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) FMN_dh PF01070.18 EMD69076.1 - 3.3e-116 388.1 0.0 4.3e-116 387.8 0.0 1.1 1 0 0 1 1 1 1 FMN-dependent dehydrogenase IMPDH PF00478.25 EMD69076.1 - 3.6e-06 26.2 1.2 7.1e-06 25.2 1.1 1.4 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain ThiG PF05690.14 EMD69076.1 - 5.2e-05 22.7 0.1 0.053 12.8 0.1 2.5 2 0 0 2 2 2 2 Thiazole biosynthesis protein ThiG Glu_synthase PF01645.17 EMD69076.1 - 0.0019 17.4 0.2 0.003 16.8 0.2 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase NMO PF03060.15 EMD69076.1 - 0.006 16.0 0.4 0.0087 15.5 0.4 1.2 1 0 0 1 1 1 1 Nitronate monooxygenase His_biosynth PF00977.21 EMD69076.1 - 0.032 13.7 0.3 1.9 7.9 0.0 2.3 1 1 1 2 2 2 0 Histidine biosynthesis protein IGPS PF00218.21 EMD69076.1 - 0.056 12.6 0.0 0.11 11.7 0.0 1.4 1 0 0 1 1 1 0 Indole-3-glycerol phosphate synthase DUF2336 PF10098.9 EMD69076.1 - 0.11 12.0 0.6 5.4 6.4 0.1 2.2 2 0 0 2 2 2 0 Uncharacterised protein conserved in bacteria (DUF2336) WD40 PF00400.32 EMD69077.1 - 4.5e-23 81.1 17.3 6e-06 26.9 0.2 9.3 10 0 0 10 10 10 7 WD domain, G-beta repeat PD40 PF07676.12 EMD69077.1 - 0.046 13.7 4.7 1.7 8.7 0.0 4.2 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat AAA PF00004.29 EMD69079.1 - 9.2e-40 136.1 0.0 8.4e-38 129.8 0.0 2.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EMD69079.1 - 1.6e-09 37.4 0.2 6.6e-09 35.4 0.2 2.2 1 1 0 1 1 1 1 AAA+ lid domain RuvB_N PF05496.12 EMD69079.1 - 2.2e-05 24.3 0.1 0.00018 21.3 0.0 2.5 3 0 0 3 3 3 1 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 EMD69079.1 - 0.00036 20.7 0.4 0.033 14.3 0.4 3.6 2 1 1 3 3 3 1 AAA domain AAA_22 PF13401.6 EMD69079.1 - 0.00088 19.6 0.3 0.071 13.4 0.1 3.4 3 0 0 3 3 3 1 AAA domain AAA_2 PF07724.14 EMD69079.1 - 0.0017 18.5 0.0 0.0047 17.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 EMD69079.1 - 0.0022 18.0 0.0 0.0064 16.5 0.0 1.9 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) TIP49 PF06068.13 EMD69079.1 - 0.0057 15.9 0.8 0.018 14.3 0.2 1.9 2 0 0 2 2 2 1 TIP49 P-loop domain AAA_14 PF13173.6 EMD69079.1 - 0.0065 16.5 0.0 0.018 15.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EMD69079.1 - 0.0067 17.0 0.1 0.03 14.8 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EMD69079.1 - 0.0067 16.8 6.0 0.024 15.0 0.1 4.0 2 1 1 4 4 4 1 AAA ATPase domain IstB_IS21 PF01695.17 EMD69079.1 - 0.015 15.1 0.1 0.077 12.7 0.0 2.1 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_28 PF13521.6 EMD69079.1 - 0.015 15.5 0.2 0.085 13.1 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 EMD69079.1 - 0.038 13.7 0.6 2.6 7.7 0.2 2.6 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 EMD69079.1 - 0.075 12.4 0.1 0.17 11.3 0.1 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 EMD69079.1 - 0.081 13.3 0.0 0.22 12.0 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_17 PF13207.6 EMD69079.1 - 0.11 12.9 2.2 0.52 10.7 0.0 3.1 3 0 0 3 3 3 0 AAA domain vATP-synt_E PF01991.18 EMD69082.1 - 1.2e-65 220.6 14.5 1.5e-65 220.4 14.5 1.0 1 0 0 1 1 1 1 ATP synthase (E/31 kDa) subunit PACT_coil_coil PF10495.9 EMD69082.1 - 0.19 12.3 4.6 1.9 9.1 2.3 2.4 2 0 0 2 2 2 0 Pericentrin-AKAP-450 domain of centrosomal targeting protein Mg_trans_NIPA PF05653.14 EMD69083.1 - 9.6e-15 54.5 7.6 1.5e-14 53.8 7.6 1.1 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 EMD69083.1 - 1.3e-05 25.4 9.6 0.00047 20.3 0.0 2.5 2 1 0 2 2 2 1 EamA-like transporter family PUNUT PF16913.5 EMD69083.1 - 0.037 13.3 10.7 0.069 12.4 10.4 1.6 1 1 0 1 1 1 0 Purine nucleobase transmembrane transport TMEM61 PF15105.6 EMD69083.1 - 0.067 13.0 0.0 0.16 11.8 0.0 1.6 1 0 0 1 1 1 0 TMEM61 protein family Neurensin PF14927.6 EMD69083.1 - 1.3 8.7 7.6 14 5.4 0.0 3.9 3 2 0 3 3 3 0 Neurensin DUF1206 PF06724.11 EMD69083.1 - 2.1 8.5 9.1 24 5.1 0.0 4.1 3 1 0 3 3 3 0 Domain of Unknown Function (DUF1206) FAD_binding_4 PF01565.23 EMD69086.1 - 2.3e-21 76.0 3.5 3.7e-21 75.3 3.5 1.4 1 0 0 1 1 1 1 FAD binding domain Nuc_deoxyri_tr2 PF15891.5 EMD69088.1 - 1e-31 109.4 0.0 1.5e-31 108.9 0.0 1.2 1 0 0 1 1 1 1 Nucleoside 2-deoxyribosyltransferase like Patatin PF01734.22 EMD69089.1 - 3.6e-24 86.1 0.0 7.8e-24 85.0 0.0 1.6 2 0 0 2 2 2 1 Patatin-like phospholipase TilS PF09179.11 EMD69089.1 - 0.082 13.4 0.0 33 5.1 0.0 2.8 3 0 0 3 3 3 0 TilS substrate binding domain Peptidase_M20 PF01546.28 EMD69092.1 - 6e-29 101.2 0.0 9.3e-29 100.6 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EMD69092.1 - 0.00027 20.8 0.0 0.00057 19.8 0.0 1.6 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 EMD69092.1 - 0.0046 16.7 0.0 0.0092 15.7 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M28 Sde2_N_Ubi PF13019.6 EMD69093.1 - 5.1e-60 202.0 0.4 5.1e-60 202.0 0.4 1.6 2 0 0 2 2 2 1 Silencing defective 2 N-terminal ubiquitin domain VIT1 PF01988.19 EMD69093.1 - 6 6.7 8.2 9.2 6.1 8.2 1.2 1 0 0 1 1 1 0 VIT family S10_plectin PF03501.15 EMD69094.1 - 2.4e-41 139.7 0.0 2.9e-41 139.4 0.0 1.1 1 0 0 1 1 1 1 Plectin/S10 domain AdoMet_MTase PF07757.13 EMD69095.1 - 3.9e-33 114.1 0.0 2.1e-16 60.3 0.0 2.4 2 0 0 2 2 2 2 Predicted AdoMet-dependent methyltransferase Acetyltransf_1 PF00583.25 EMD69095.1 - 1.1e-09 38.6 0.0 2.3e-09 37.5 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EMD69095.1 - 2.3e-07 30.8 0.0 4.9e-07 29.7 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EMD69095.1 - 1.1e-06 28.9 0.1 2.9e-06 27.6 0.1 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Methyltransf_23 PF13489.6 EMD69095.1 - 0.029 14.2 0.0 0.087 12.7 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain DUF3906 PF13046.6 EMD69095.1 - 0.22 11.6 0.1 0.22 11.6 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3906) Pentapeptide PF00805.22 EMD69095.1 - 0.24 11.1 0.1 0.41 10.3 0.1 1.4 1 0 0 1 1 1 0 Pentapeptide repeats (8 copies) SEN1_N PF12726.7 EMD69097.1 - 1.4e-201 671.7 3.6 1.9e-201 671.2 3.6 1.2 1 0 0 1 1 1 1 SEN1 N terminal AAA_11 PF13086.6 EMD69097.1 - 2.1e-72 244.0 3.1 2.1e-72 244.0 3.1 3.3 3 0 0 3 3 3 1 AAA domain AAA_12 PF13087.6 EMD69097.1 - 1.1e-60 204.6 0.0 2.5e-60 203.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EMD69097.1 - 6.8e-11 42.2 1.0 2.2e-06 27.6 0.1 2.8 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.6 EMD69097.1 - 3.1e-08 34.1 0.0 1.5e-07 31.8 0.0 2.2 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 EMD69097.1 - 1.2e-06 28.5 0.0 0.011 15.5 0.0 3.5 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase DEAD PF00270.29 EMD69097.1 - 0.0025 17.6 0.8 0.0092 15.8 0.1 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase T2SSE PF00437.20 EMD69097.1 - 0.0026 16.9 0.1 0.0078 15.3 0.1 1.8 1 0 0 1 1 1 1 Type II/IV secretion system protein ResIII PF04851.15 EMD69097.1 - 0.0051 16.8 0.3 0.048 13.7 0.3 2.7 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EMD69097.1 - 0.074 13.3 0.4 3 8.1 0.0 3.4 3 0 0 3 3 2 0 AAA domain Annexin PF00191.20 EMD69097.1 - 0.28 11.3 1.8 0.44 10.6 0.1 2.3 2 0 0 2 2 2 0 Annexin AAA_16 PF13191.6 EMD69097.1 - 0.47 10.8 4.0 0.47 10.8 0.2 3.0 2 1 0 2 2 2 0 AAA ATPase domain AAA_23 PF13476.6 EMD69097.1 - 3.3 8.2 20.6 0.02 15.4 3.5 3.3 3 0 0 3 3 3 0 AAA domain AA_permease_2 PF13520.6 EMD69098.1 - 1.2e-51 175.9 41.4 1.5e-51 175.6 41.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EMD69098.1 - 4.1e-22 78.4 40.6 2e-21 76.2 40.6 1.8 1 1 0 1 1 1 1 Amino acid permease SRF-TF PF00319.18 EMD69099.1 - 3.6e-21 74.4 0.1 5.1e-21 73.9 0.1 1.2 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) Tetraspanin PF00335.20 EMD69100.1 - 0.0004 20.2 10.0 0.00086 19.1 10.0 1.5 1 1 0 1 1 1 1 Tetraspanin family FxsA PF04186.13 EMD69100.1 - 1.1 9.4 5.9 0.29 11.2 1.0 2.3 3 0 0 3 3 3 0 FxsA cytoplasmic membrane protein UPF0449 PF15136.6 EMD69101.1 - 1.3 9.6 5.8 7.9 7.0 4.8 2.8 2 1 0 2 2 2 0 Uncharacterised protein family UPF0449 PhoLip_ATPase_C PF16212.5 EMD69102.1 - 5.7e-79 265.4 25.8 5.7e-79 265.4 25.8 2.0 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EMD69102.1 - 1.7e-19 69.2 0.8 5.4e-19 67.7 0.8 1.9 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 EMD69102.1 - 6.9e-11 42.1 0.0 2.8e-10 40.1 0.0 1.9 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EMD69102.1 - 8e-11 42.6 0.1 9e-06 26.1 0.0 3.0 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 EMD69102.1 - 0.0012 18.4 0.0 0.0012 18.4 0.0 2.9 4 0 0 4 4 4 1 E1-E2 ATPase Hydrolase_3 PF08282.12 EMD69102.1 - 0.021 14.6 0.1 0.042 13.6 0.1 1.4 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase CBM-like PF14683.6 EMD69104.1 - 6.6e-26 91.1 0.0 1.1e-25 90.4 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide lyase family 4, domain III fn3_3 PF14686.6 EMD69104.1 - 2.7e-22 78.3 0.1 6.9e-22 77.0 0.1 1.8 1 0 0 1 1 1 1 Polysaccharide lyase family 4, domain II MFS_1 PF07690.16 EMD69105.1 - 3.3e-21 75.6 41.7 2.2e-20 72.9 25.0 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily Lyase_1 PF00206.20 EMD69107.1 - 2.8e-93 312.8 0.0 4.6e-93 312.0 0.0 1.3 1 0 0 1 1 1 1 Lyase ASL_C2 PF14698.6 EMD69107.1 - 6.6e-23 81.2 0.0 2.2e-22 79.6 0.0 2.0 1 0 0 1 1 1 1 Argininosuccinate lyase C-terminal DUF2573 PF10835.8 EMD69107.1 - 0.037 14.4 0.5 0.58 10.5 0.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2573) HemY_N PF07219.13 EMD69109.1 - 0.039 14.1 2.0 0.045 13.9 2.0 1.2 1 0 0 1 1 1 0 HemY protein N-terminus zf-CCHC PF00098.23 EMD69109.1 - 0.29 11.3 3.2 0.48 10.6 3.2 1.3 1 0 0 1 1 1 0 Zinc knuckle SNF2_N PF00176.23 EMD69110.1 - 9.9e-55 185.6 0.0 1.8e-54 184.8 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EMD69110.1 - 8.7e-13 48.6 0.0 1.7e-12 47.6 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 EMD69110.1 - 5.9e-06 25.7 0.0 9.5e-06 25.0 0.0 1.2 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase ResIII PF04851.15 EMD69110.1 - 0.00052 20.1 0.0 0.0057 16.7 0.0 2.2 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EMD69110.1 - 0.0015 18.3 0.2 0.019 14.7 0.2 2.4 1 1 0 1 1 1 1 DEAD/DEAH box helicase zf-RING_5 PF14634.6 EMD69110.1 - 0.0028 17.6 9.9 0.0028 17.6 9.9 2.1 2 0 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EMD69110.1 - 0.11 12.4 11.4 0.046 13.6 8.0 2.1 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 EMD69110.1 - 0.23 11.4 7.6 3.4 7.6 8.2 2.5 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EMD69110.1 - 0.3 11.2 6.9 0.55 10.3 5.6 2.3 2 0 0 2 2 2 0 RING-type zinc-finger zf-RING_2 PF13639.6 EMD69110.1 - 1.2 9.5 10.7 1.8 8.9 9.2 2.2 2 0 0 2 2 2 0 Ring finger domain zf-UDP PF14569.6 EMD69110.1 - 1.7 8.8 5.9 1.6 8.9 4.5 1.7 2 0 0 2 2 2 0 Zinc-binding RING-finger Zn-ribbon_8 PF09723.10 EMD69110.1 - 4.2 7.6 8.3 3.1 8.0 3.5 2.5 2 0 0 2 2 2 0 Zinc ribbon domain zf-C2H2 PF00096.26 EMD69111.1 - 1.3e-12 47.4 14.8 0.00013 22.2 1.3 4.9 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMD69111.1 - 2.1e-05 24.9 23.0 0.041 14.7 0.8 6.1 6 0 0 6 6 6 3 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EMD69111.1 - 4e-05 23.5 6.9 0.034 14.2 0.4 4.1 4 0 0 4 4 4 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EMD69111.1 - 0.00015 22.0 11.1 0.0046 17.3 0.1 5.2 4 0 0 4 4 4 1 Zinc-finger double domain zf-Di19 PF05605.12 EMD69111.1 - 0.00023 21.4 1.4 0.00023 21.4 1.4 2.5 2 0 0 2 2 2 1 Drought induced 19 protein (Di19), zinc-binding zf-met PF12874.7 EMD69111.1 - 0.0005 20.4 8.2 0.0032 17.8 0.4 3.8 4 0 0 4 4 4 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EMD69111.1 - 0.016 15.5 12.8 0.075 13.4 1.2 4.6 5 0 0 5 5 5 0 Zinc-finger double-stranded RNA-binding NACHT PF05729.12 EMD69111.1 - 0.075 12.9 0.0 0.21 11.5 0.0 1.8 1 0 0 1 1 1 0 NACHT domain Zn_ribbon_recom PF13408.6 EMD69111.1 - 0.84 10.2 3.0 7.1 7.2 1.1 2.5 1 1 1 2 2 2 0 Recombinase zinc beta ribbon domain DUF2470 PF10615.9 EMD69112.1 - 1.2e-16 61.1 1.0 1.9e-16 60.5 1.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2470) DUF4499 PF14934.6 EMD69112.1 - 0.022 15.1 1.6 0.038 14.3 1.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4499) Transformer PF06495.11 EMD69113.1 - 0.045 13.8 5.7 0.076 13.1 5.7 1.3 1 0 0 1 1 1 0 Fruit fly transformer protein Macoilin PF09726.9 EMD69113.1 - 0.13 10.8 4.2 0.16 10.5 4.2 1.1 1 0 0 1 1 1 0 Macoilin family Inhibitor_I53 PF11714.8 EMD69113.1 - 0.79 10.0 6.1 0.47 10.7 3.7 1.8 2 0 0 2 2 2 0 Thrombin inhibitor Madanin PAPS_reduct PF01507.19 EMD69114.1 - 0.097 12.7 0.7 0.12 12.4 0.7 1.1 1 0 0 1 1 1 0 Phosphoadenosine phosphosulfate reductase family NPAT_C PF15712.5 EMD69114.1 - 0.17 10.5 4.1 0.19 10.3 4.1 1.0 1 0 0 1 1 1 0 NPAT C terminus RasGEF PF00617.19 EMD69117.1 - 6e-41 140.6 0.0 1.2e-40 139.6 0.0 1.5 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 EMD69117.1 - 1.6e-13 50.8 0.0 4.9e-13 49.2 0.0 1.8 1 0 0 1 1 1 1 RasGEF N-terminal motif Ras PF00071.22 EMD69117.1 - 2e-05 24.2 0.1 5.3e-05 22.9 0.0 1.7 2 0 0 2 2 2 1 Ras family AAA_33 PF13671.6 EMD69117.1 - 0.0032 17.7 0.1 0.014 15.6 0.1 2.2 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EMD69117.1 - 0.019 15.5 1.1 2.4 8.7 0.0 3.8 4 0 0 4 4 4 0 AAA domain AAA_16 PF13191.6 EMD69117.1 - 0.13 12.6 0.1 0.58 10.5 0.0 2.1 1 1 1 2 2 2 0 AAA ATPase domain DUF1512 PF07431.12 EMD69117.1 - 0.19 10.7 0.4 0.3 10.0 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1512) PRTP PF01366.18 EMD69118.1 - 0.028 12.5 0.1 0.028 12.5 0.1 1.1 1 0 0 1 1 1 0 Herpesvirus processing and transport protein HBD PF18534.1 EMD69118.1 - 0.031 14.4 0.2 0.06 13.5 0.2 1.5 1 0 0 1 1 1 0 Helical bundle domain TEX13 PF15186.6 EMD69118.1 - 0.095 12.4 0.5 0.17 11.6 0.5 1.3 1 0 0 1 1 1 0 Testis-expressed sequence 13 protein family Corona_S2 PF01601.16 EMD69119.1 - 9.6 4.6 15.7 13 4.1 15.7 1.1 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein DUF5316 PF17247.2 EMD69120.1 - 0.62 10.1 7.6 0.12 12.4 2.1 2.0 1 1 1 2 2 2 0 Family of unknown function (DUF5316) TRP PF06011.12 EMD69121.1 - 2e-108 362.9 17.4 2.4e-108 362.6 17.4 1.1 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.6 EMD69121.1 - 1.3e-34 119.5 0.0 2.1e-34 118.8 0.0 1.3 1 0 0 1 1 1 1 ML-like domain SP_C-Propep PF08999.10 EMD69121.1 - 0.011 15.4 2.8 0.017 14.9 0.0 2.5 3 0 0 3 3 3 0 Surfactant protein C, N terminal propeptide 4HBT PF03061.22 EMD69122.1 - 0.14 12.5 0.0 0.24 11.8 0.0 1.4 1 0 0 1 1 1 0 Thioesterase superfamily GFA PF04828.14 EMD69123.1 - 0.0007 19.9 0.3 0.0007 19.9 0.3 1.8 2 0 0 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme zf-C2H2 PF00096.26 EMD69127.1 - 1e-11 44.6 12.8 4.6e-06 26.8 0.6 3.2 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMD69127.1 - 2.8e-09 37.0 8.9 0.00036 21.1 0.6 2.9 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EMD69127.1 - 3.8e-07 30.2 12.6 2e-05 24.8 2.3 3.3 3 0 0 3 3 3 2 Zinc-finger double domain zf-H2C2_5 PF13909.6 EMD69127.1 - 3.5e-05 23.4 7.4 0.007 16.1 0.2 2.7 2 0 0 2 2 2 2 C2H2-type zinc-finger domain zf-C2H2_jaz PF12171.8 EMD69127.1 - 0.0006 20.0 4.1 0.013 15.7 0.1 2.5 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 EMD69127.1 - 0.002 18.1 5.0 0.69 10.0 0.3 2.9 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2HE PF16278.5 EMD69127.1 - 0.019 15.4 8.5 1 9.8 1.0 2.5 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_11 PF16622.5 EMD69127.1 - 0.13 12.0 1.9 5.5 6.8 0.2 2.4 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-met PF12874.7 EMD69127.1 - 0.38 11.2 0.2 0.38 11.2 0.2 2.6 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-AN1 PF01428.16 EMD69127.1 - 3.2 8.0 8.3 14 5.9 1.6 2.4 1 1 1 2 2 2 0 AN1-like Zinc finger Pkinase PF00069.25 EMD69128.1 - 2.7e-69 233.5 0.0 3.1e-68 230.0 0.0 2.2 1 1 0 1 1 1 1 Protein kinase domain Fungal_KA1 PF16797.5 EMD69128.1 - 3.1e-36 123.7 0.2 7e-36 122.5 0.2 1.7 1 0 0 1 1 1 1 Fungal kinase associated-1 domain Pkinase_Tyr PF07714.17 EMD69128.1 - 5.2e-32 111.1 0.0 1.1e-31 110.1 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EMD69128.1 - 0.0019 17.6 0.1 0.0038 16.6 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EMD69128.1 - 0.0097 14.9 0.1 0.0097 14.9 0.1 2.1 2 0 0 2 2 2 1 Haspin like kinase domain APH PF01636.23 EMD69128.1 - 0.022 14.7 0.0 0.056 13.3 0.0 1.7 1 0 0 1 1 1 0 Phosphotransferase enzyme family Choline_kinase PF01633.20 EMD69128.1 - 0.024 14.2 0.7 0.062 12.9 0.0 2.0 2 0 0 2 2 2 0 Choline/ethanolamine kinase SMN PF06003.12 EMD69128.1 - 0.031 13.5 0.8 0.091 12.0 0.8 1.7 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) Ribosomal_L24e PF01246.20 EMD69129.1 - 1.2e-29 102.3 0.2 2.9e-29 101.1 0.2 1.6 1 0 0 1 1 1 1 Ribosomal protein L24e DUF775 PF05603.12 EMD69129.1 - 0.26 10.8 1.9 0.33 10.4 1.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF775) Haem_degrading PF03928.14 EMD69131.1 - 1.4e-30 105.8 0.2 1.7e-30 105.5 0.2 1.1 1 0 0 1 1 1 1 Haem-degrading Diacid_rec PF05651.13 EMD69131.1 - 0.021 14.5 4.0 6.7 6.4 4.0 2.2 1 1 0 1 1 1 0 Putative sugar diacid recognition DUF3632 PF12311.8 EMD69132.1 - 8.9e-41 140.2 1.9 1.2e-40 139.8 1.9 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3632) AMP-binding PF00501.28 EMD69133.1 - 2.9e-76 256.8 0.0 3.8e-76 256.4 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EMD69133.1 - 1.9e-14 54.4 1.4 4.1e-14 53.3 1.4 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Wbp11 PF09429.10 EMD69135.1 - 3.6e-21 75.3 17.4 3.6e-21 75.3 17.4 2.3 2 1 1 3 3 3 1 WW domain binding protein 11 HSP9_HSP12 PF04119.12 EMD69136.1 - 6.6e-23 80.9 1.0 6.6e-23 80.9 1.0 2.0 2 0 0 2 2 2 1 Heat shock protein 9/12 Glyco_hydro_76 PF03663.14 EMD69137.1 - 4.4e-42 144.9 9.9 5.5e-42 144.6 9.9 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_127 PF07944.12 EMD69137.1 - 0.0025 16.4 0.1 0.0031 16.1 0.1 1.4 1 1 0 1 1 1 1 Beta-L-arabinofuranosidase, GH127 C5-epim_C PF06662.13 EMD69137.1 - 0.024 14.1 0.2 0.15 11.6 0.1 2.2 2 0 0 2 2 2 0 D-glucuronyl C5-epimerase C-terminus MatE PF01554.18 EMD69138.1 - 7.1e-62 207.8 18.8 4e-31 107.8 6.4 2.2 2 0 0 2 2 2 2 MatE Polysacc_synt_C PF14667.6 EMD69138.1 - 4.7e-07 30.0 6.6 4.7e-07 30.0 6.6 4.5 3 2 1 5 5 5 1 Polysaccharide biosynthesis C-terminal domain Arginase PF00491.21 EMD69139.1 - 3.7e-93 312.0 0.0 4.9e-93 311.7 0.0 1.0 1 0 0 1 1 1 1 Arginase family UPF0489 PF12640.7 EMD69139.1 - 0.059 13.6 0.1 0.09 13.0 0.1 1.3 1 0 0 1 1 1 0 UPF0489 domain DUF2407_C PF13373.6 EMD69140.1 - 8.4e-39 132.9 0.0 1.2e-38 132.5 0.0 1.2 1 0 0 1 1 1 1 DUF2407 C-terminal domain DUF2407 PF10302.9 EMD69140.1 - 4.9e-31 107.4 0.0 1.1e-30 106.3 0.0 1.6 2 0 0 2 2 2 1 DUF2407 ubiquitin-like domain ubiquitin PF00240.23 EMD69140.1 - 0.0034 17.1 0.0 0.006 16.3 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family Dabb PF07876.12 EMD69141.1 - 8.5e-24 84.0 0.0 9.6e-24 83.8 0.0 1.0 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain Fe-S_biosyn PF01521.20 EMD69142.1 - 2.1e-17 63.3 0.0 2.7e-17 63.0 0.0 1.1 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis zf-C2HC_2 PF13913.6 EMD69142.1 - 0.77 9.7 6.7 0.42 10.6 1.5 2.3 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf-C2H2_4 PF13894.6 EMD69142.1 - 2.3 9.3 3.9 1.6 9.8 0.3 2.4 2 0 0 2 2 2 0 C2H2-type zinc finger Arc PF03869.14 EMD69143.1 - 9.5e-05 22.2 2.3 0.41 10.5 0.0 3.1 3 0 0 3 3 3 2 Arc-like DNA binding domain Annexin PF00191.20 EMD69143.1 - 0.07 13.2 0.2 7.8 6.7 0.0 2.3 2 0 0 2 2 2 0 Annexin SR-25 PF10500.9 EMD69143.1 - 0.14 11.8 11.9 0.18 11.4 11.9 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF908 PF06012.12 EMD69143.1 - 9.8 5.5 14.5 13 5.1 14.5 1.3 1 1 0 1 1 1 0 Domain of Unknown Function (DUF908) Ribosomal_S8e PF01201.22 EMD69145.1 - 4.3e-55 185.6 1.9 5e-55 185.4 1.9 1.1 1 0 0 1 1 1 1 Ribosomal protein S8e Malate_synthase PF01274.22 EMD69146.1 - 1.8e-229 762.4 0.1 2.1e-229 762.2 0.1 1.0 1 0 0 1 1 1 1 Malate synthase HpcH_HpaI PF03328.14 EMD69146.1 - 0.12 11.5 0.0 0.19 10.8 0.0 1.4 1 0 0 1 1 1 0 HpcH/HpaI aldolase/citrate lyase family F-box-like PF12937.7 EMD69149.1 - 1.5e-07 31.2 0.1 3.7e-07 29.9 0.1 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EMD69149.1 - 7.4e-07 28.9 0.2 3.3e-06 26.8 0.0 2.0 2 0 0 2 2 2 1 F-box domain adh_short PF00106.25 EMD69150.1 - 8.8e-28 97.1 0.0 1.1e-27 96.8 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD69150.1 - 7e-19 68.3 0.0 9e-19 68.0 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD69150.1 - 4.3e-07 30.0 0.0 6e-07 29.6 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EMD69150.1 - 0.0065 15.9 0.0 0.012 15.1 0.0 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EMD69150.1 - 0.053 13.4 0.0 0.15 11.9 0.0 1.9 1 1 1 2 2 2 0 NAD(P)H-binding Halo_GVPC PF05465.13 EMD69150.1 - 0.12 12.6 0.4 0.33 11.3 0.4 1.7 1 0 0 1 1 1 0 Halobacterial gas vesicle protein C (GVPC) repeat Cytochrom_C PF00034.21 EMD69151.1 - 9.7e-10 39.5 0.0 1.3e-09 39.1 0.0 1.2 1 0 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.6 EMD69151.1 - 2.8e-08 34.0 1.6 1e-07 32.2 1.6 1.7 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C550 PF14495.6 EMD69151.1 - 0.01 15.5 2.1 0.068 12.9 2.1 2.2 1 1 0 1 1 1 0 Cytochrome c-550 domain Cytochrome-c551 PF10643.9 EMD69151.1 - 0.19 11.3 0.0 0.19 11.3 0.0 1.2 1 0 0 1 1 1 0 Photosystem P840 reaction-centre cytochrome c-551 BCDHK_Adom3 PF10436.9 EMD69152.1 - 4.5e-76 254.2 0.0 6.5e-76 253.7 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 EMD69152.1 - 7.6e-13 49.0 0.0 2e-12 47.6 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 EMD69152.1 - 0.093 12.6 0.0 0.17 11.7 0.0 1.5 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase SF3b10 PF07189.11 EMD69153.1 - 0.073 13.2 0.0 0.15 12.2 0.0 1.5 1 0 0 1 1 1 0 Splicing factor 3B subunit 10 (SF3b10) 6PF2K PF01591.18 EMD69154.1 - 1.1e-82 276.7 0.1 1.6e-82 276.2 0.1 1.1 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 EMD69154.1 - 1.1e-35 123.0 0.0 1.7e-35 122.5 0.0 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 EMD69154.1 - 6.5e-06 26.4 0.0 1.2e-05 25.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.10 EMD69154.1 - 0.0006 19.4 0.1 0.00097 18.7 0.1 1.3 1 0 0 1 1 1 1 Chromatin associated protein KTI12 DUF4248 PF14053.6 EMD69154.1 - 0.049 13.7 0.0 0.29 11.2 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4248) Rxt3 PF08642.10 EMD69155.1 - 1.7e-33 116.1 0.0 4.6e-33 114.7 0.0 1.8 1 0 0 1 1 1 1 Histone deacetylation protein Rxt3 LCCL PF03815.19 EMD69155.1 - 0.00012 22.2 0.0 0.034 14.3 0.0 2.5 2 0 0 2 2 2 2 LCCL domain CLN3 PF02487.17 EMD69156.1 - 2.5e-165 550.4 3.5 2.8e-165 550.2 3.5 1.0 1 0 0 1 1 1 1 CLN3 protein MFS_1 PF07690.16 EMD69156.1 - 5.4e-07 28.9 4.6 5.4e-07 28.9 4.6 2.7 1 1 1 2 2 2 2 Major Facilitator Superfamily SpoIIP PF07454.11 EMD69157.1 - 0.29 10.5 24.6 0.31 10.4 24.6 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) CobT PF06213.12 EMD69157.1 - 0.49 9.7 31.0 0.56 9.6 31.0 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF3807 PF12720.7 EMD69157.1 - 0.66 10.2 30.3 0.75 10.0 30.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) RR_TM4-6 PF06459.12 EMD69157.1 - 1.2 8.9 26.7 1.3 8.8 26.7 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Pannexin_like PF12534.8 EMD69157.1 - 1.6 7.8 17.7 1.8 7.6 17.7 1.0 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 CPSF100_C PF13299.6 EMD69157.1 - 1.7 8.8 22.8 2 8.6 22.8 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Dynamin_N PF00350.23 EMD69157.1 - 2.1 8.4 11.4 2.4 8.2 11.4 1.1 1 0 0 1 1 1 0 Dynamin family Presenilin PF01080.17 EMD69157.1 - 2.1 7.0 30.8 2.4 6.9 30.8 1.0 1 0 0 1 1 1 0 Presenilin Tim54 PF11711.8 EMD69157.1 - 2.2 7.0 26.1 2.5 6.8 26.1 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 TFIIA PF03153.13 EMD69157.1 - 2.3 8.1 58.5 2.8 7.8 58.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF3292 PF11696.8 EMD69157.1 - 2.3 6.5 24.7 2.5 6.3 24.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) eIF-3_zeta PF05091.12 EMD69157.1 - 2.3 7.1 32.3 2.5 7.0 32.3 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF3987 PF13148.6 EMD69157.1 - 2.3 7.1 17.0 2.6 6.9 17.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) RNA_pol_Rpc4 PF05132.14 EMD69157.1 - 2.6 8.5 23.8 2.8 8.4 23.8 1.1 1 0 0 1 1 1 0 RNA polymerase III RPC4 PPL5 PF18168.1 EMD69157.1 - 2.8 7.2 15.8 3.1 7.0 15.8 1.0 1 0 0 1 1 1 0 Prim-pol family 5 NPR3 PF03666.13 EMD69157.1 - 2.8 6.6 23.4 3 6.5 23.4 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DDHD PF02862.17 EMD69157.1 - 3.1 7.9 21.6 3.5 7.7 21.6 1.1 1 0 0 1 1 1 0 DDHD domain DUF4770 PF15994.5 EMD69157.1 - 3.2 8.0 31.6 3.9 7.7 31.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) DUF4407 PF14362.6 EMD69157.1 - 3.5 6.9 24.7 4.1 6.7 24.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) MMU163 PF17119.5 EMD69157.1 - 3.5 6.7 11.7 4.1 6.5 11.7 1.2 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis NARP1 PF12569.8 EMD69157.1 - 3.7 6.3 24.0 4 6.2 24.0 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 FAM176 PF14851.6 EMD69157.1 - 3.9 7.1 15.0 4.7 6.9 15.0 1.3 1 0 0 1 1 1 0 FAM176 family DUF2126 PF09899.9 EMD69157.1 - 3.9 5.4 18.5 4 5.4 18.5 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) DUF4746 PF15928.5 EMD69157.1 - 4.5 6.6 17.9 5.1 6.4 17.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Pex14_N PF04695.13 EMD69157.1 - 4.6 7.9 44.5 6.1 7.5 44.5 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Band_3_cyto PF07565.13 EMD69157.1 - 4.9 6.9 22.4 5.4 6.7 22.4 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain eIF3_subunit PF08597.10 EMD69157.1 - 5.1 6.9 23.6 5.9 6.7 23.6 1.2 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit Paf1 PF03985.13 EMD69157.1 - 5.2 6.0 27.7 6 5.8 27.7 1.0 1 0 0 1 1 1 0 Paf1 Pal1 PF08316.11 EMD69157.1 - 5.9 7.7 12.5 7.5 7.3 12.5 1.2 1 0 0 1 1 1 0 Pal1 cell morphology protein FixO PF02433.15 EMD69157.1 - 5.9 6.3 13.6 7 6.0 13.6 1.2 1 0 0 1 1 1 0 Cytochrome C oxidase, mono-heme subunit/FixO CCSAP PF15748.5 EMD69157.1 - 6.1 6.9 31.2 6.7 6.8 31.2 1.0 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated TERB2 PF15101.6 EMD69157.1 - 6.4 6.8 33.3 7.5 6.5 33.3 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Rtf2 PF04641.12 EMD69157.1 - 6.5 6.0 21.3 7.3 5.9 21.3 1.0 1 0 0 1 1 1 0 Rtf2 RING-finger Endostatin PF06482.11 EMD69157.1 - 6.6 6.1 27.8 7.1 6.0 27.8 1.0 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin V_ATPase_I PF01496.19 EMD69157.1 - 6.8 4.5 25.5 7.6 4.3 25.5 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF2828 PF11443.8 EMD69157.1 - 6.9 4.6 24.2 7.6 4.5 24.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) FAM60A PF15396.6 EMD69157.1 - 7.3 6.5 19.8 8.4 6.3 19.8 1.1 1 0 0 1 1 1 0 Protein Family FAM60A CSG2 PF16965.5 EMD69157.1 - 7.7 5.4 14.4 8.1 5.3 14.4 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator DUF2151 PF10221.9 EMD69157.1 - 7.8 4.9 15.5 8.5 4.8 15.5 1.0 1 0 0 1 1 1 0 Cell cycle and development regulator PRC2_HTH_1 PF18118.1 EMD69157.1 - 8.1 7.3 17.1 11 6.9 17.1 1.3 1 0 0 1 1 1 0 Polycomb repressive complex 2 tri-helical domain STAC2_u1 PF16664.5 EMD69157.1 - 8.5 6.8 20.1 10 6.6 20.1 1.1 1 0 0 1 1 1 0 Unstructured on SH3 and cysteine-rich domain-containing protein 2 SpoVR PF04293.13 EMD69157.1 - 9 4.9 21.4 10 4.7 21.4 1.0 1 0 0 1 1 1 0 SpoVR like protein PTPRCAP PF15713.5 EMD69157.1 - 9.1 6.6 25.3 11 6.3 25.3 1.1 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated GAGA_bind PF06217.12 EMD69157.1 - 9.6 6.4 24.4 10 6.3 24.4 1.0 1 0 0 1 1 1 0 GAGA binding protein-like family Connexin PF00029.19 EMD69157.1 - 9.6 5.9 20.8 11 5.7 20.8 1.1 1 0 0 1 1 1 0 Connexin GNAT_acetyltr_2 PF13718.6 EMD69157.1 - 9.8 5.5 15.4 13 5.1 15.4 1.3 1 0 0 1 1 1 0 GNAT acetyltransferase 2 OSCP PF00213.18 EMD69158.1 - 1.6e-44 152.1 1.4 1.9e-44 151.8 1.4 1.1 1 0 0 1 1 1 1 ATP synthase delta (OSCP) subunit DUF4461 PF14688.6 EMD69158.1 - 0.1 12.4 0.0 0.13 12.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4461) PA28_alpha PF02251.18 EMD69158.1 - 0.14 12.3 1.1 0.47 10.5 0.1 2.0 2 0 0 2 2 2 0 Proteasome activator pa28 alpha subunit BES1_N PF05687.13 EMD69159.1 - 1.9 8.8 3.6 0.88 10.0 0.6 1.9 2 0 0 2 2 2 0 BES1/BZR1 plant transcription factor, N-terminal Asp PF00026.23 EMD69160.1 - 5.2e-12 45.8 0.8 7.1e-12 45.4 0.8 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease SKG6 PF08693.10 EMD69160.1 - 1.6e-05 24.2 1.4 3.1e-05 23.3 1.4 1.5 1 0 0 1 1 1 1 Transmembrane alpha-helix domain CD34_antigen PF06365.12 EMD69160.1 - 0.0064 16.1 0.0 0.011 15.3 0.0 1.3 1 0 0 1 1 1 1 CD34/Podocalyxin family Adeno_E3_CR2 PF02439.15 EMD69160.1 - 0.012 15.4 0.6 0.025 14.4 0.6 1.5 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Rax2 PF12768.7 EMD69160.1 - 0.017 14.6 0.2 0.19 11.2 0.0 2.3 2 0 0 2 2 2 0 Cortical protein marker for cell polarity EphA2_TM PF14575.6 EMD69160.1 - 0.019 15.9 0.0 0.031 15.1 0.0 1.4 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Glycophorin_A PF01102.18 EMD69160.1 - 0.021 15.0 0.0 0.064 13.5 0.0 1.8 1 0 0 1 1 1 0 Glycophorin A Romo1 PF10247.9 EMD69160.1 - 0.031 14.7 0.3 0.23 11.8 0.0 2.2 2 0 0 2 2 2 0 Reactive mitochondrial oxygen species modulator 1 CPCFC PF17223.3 EMD69160.1 - 0.23 11.2 1.5 0.59 9.9 1.5 1.7 1 0 0 1 1 1 0 Cuticle protein CPCFC Syndecan PF01034.20 EMD69160.1 - 1.3 9.0 2.7 1.1 9.2 0.7 1.9 2 0 0 2 2 2 0 Syndecan domain Rgp1 PF08737.10 EMD69163.1 - 2.7e-152 507.7 0.0 1.1e-151 505.8 0.0 2.0 3 0 0 3 3 3 1 Rgp1 Arrestin_N PF00339.29 EMD69163.1 - 0.0016 18.5 0.0 0.0039 17.3 0.0 1.6 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 EMD69163.1 - 0.01 16.3 0.0 2.3 8.7 0.0 2.8 3 0 0 3 3 3 2 Arrestin (or S-antigen), C-terminal domain Sigma70_ECF PF07638.11 EMD69164.1 - 0.00013 21.9 1.9 0.00014 21.8 1.9 1.1 1 0 0 1 1 1 1 ECF sigma factor SR-25 PF10500.9 EMD69164.1 - 0.00052 19.7 5.5 0.00062 19.4 5.5 1.1 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein CCDC106 PF15794.5 EMD69164.1 - 0.0018 18.0 4.0 0.0021 17.8 4.0 1.1 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 106 AP3D1 PF06375.11 EMD69164.1 - 0.0055 17.0 6.3 0.0064 16.7 6.3 1.1 1 0 0 1 1 1 1 AP-3 complex subunit delta-1 TT_ORF2 PF02957.15 EMD69164.1 - 0.025 15.5 0.4 0.031 15.2 0.4 1.1 1 0 0 1 1 1 0 TT viral ORF2 Med19 PF10278.9 EMD69164.1 - 0.48 10.3 10.4 0.62 10.0 10.4 1.1 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 Ribosomal_S25 PF03297.15 EMD69164.1 - 0.85 9.9 9.1 0.76 10.0 8.1 1.4 1 1 0 1 1 1 0 S25 ribosomal protein UPF0239 PF06783.11 EMD69164.1 - 8.7 6.6 11.8 13 6.1 11.8 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0239) DUF2236 PF09995.9 EMD69165.1 - 3.4e-32 112.5 0.2 6.3e-32 111.6 0.1 1.4 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2236) Neugrin PF06413.11 EMD69166.1 - 3.2e-12 46.9 0.3 5.5e-12 46.2 0.3 1.3 1 0 0 1 1 1 1 Neugrin MRP-L20 PF12824.7 EMD69166.1 - 1.9e-06 28.2 1.5 3.1e-06 27.5 1.5 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal protein subunit L20 HTH_32 PF13565.6 EMD69166.1 - 4.2 8.1 7.1 0.46 11.1 0.5 2.8 3 1 0 3 3 3 0 Homeodomain-like domain Phage_holin_2_4 PF16082.5 EMD69167.1 - 0.31 10.8 0.1 0.31 10.8 0.1 1.9 2 0 0 2 2 2 0 Bacteriophage holin family, superfamily II-like Pkinase PF00069.25 EMD69171.1 - 1.6e-66 224.4 0.0 2.4e-66 223.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD69171.1 - 5.4e-46 157.0 0.0 9.4e-46 156.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ras_bdg_2 PF14847.6 EMD69171.1 - 8.1e-25 87.1 0.0 2.8e-24 85.3 0.0 2.0 2 0 0 2 2 2 1 Ras-binding domain of Byr2 SAM_2 PF07647.17 EMD69171.1 - 6.3e-16 58.3 0.3 1.6e-15 57.0 0.3 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 EMD69171.1 - 1.6e-15 57.2 0.5 3.3e-15 56.3 0.5 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Kinase-like PF14531.6 EMD69171.1 - 8.9e-07 28.5 0.1 0.0031 16.9 0.0 3.0 3 0 0 3 3 3 2 Kinase-like RA PF00788.23 EMD69171.1 - 4.6e-05 24.0 0.0 8.5e-05 23.1 0.0 1.5 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain SAM_4 PF18017.1 EMD69171.1 - 0.0083 16.1 0.1 0.019 14.9 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) IGR PF09597.10 EMD69171.1 - 0.03 14.4 0.0 0.071 13.2 0.0 1.5 1 0 0 1 1 1 0 IGR protein motif SAM_PNT PF02198.16 EMD69171.1 - 0.091 12.7 0.0 0.19 11.8 0.0 1.4 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain SAM_3 PF18016.1 EMD69171.1 - 0.11 12.3 0.0 0.39 10.6 0.0 1.9 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) Seadorna_VP7 PF07387.11 EMD69171.1 - 0.15 11.1 0.0 0.3 10.1 0.0 1.4 1 0 0 1 1 1 0 Seadornavirus VP7 Pkinase_fungal PF17667.1 EMD69171.1 - 0.15 10.8 0.6 0.4 9.4 0.0 1.8 2 0 0 2 2 2 0 Fungal protein kinase ADH_zinc_N PF00107.26 EMD69172.1 - 1.1e-25 90.2 2.1 1.9e-25 89.3 2.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EMD69172.1 - 2.5e-25 88.4 2.2 2.5e-25 88.4 2.2 2.1 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 EMD69172.1 - 1.1e-05 26.5 0.1 2.8e-05 25.2 0.1 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase UBA PF00627.31 EMD69174.1 - 3.1e-05 23.8 0.0 7.1e-05 22.6 0.0 1.6 1 0 0 1 1 1 1 UBA/TS-N domain F-box PF00646.33 EMD69174.1 - 0.0079 16.0 0.0 0.016 15.1 0.0 1.5 1 0 0 1 1 1 1 F-box domain Innate_immun PF12782.7 EMD69174.1 - 0.48 9.9 1.8 0.77 9.2 1.8 1.2 1 0 0 1 1 1 0 Invertebrate innate immunity transcript family Fungal_trans_2 PF11951.8 EMD69177.1 - 3.2e-56 190.8 3.5 4.2e-56 190.4 3.5 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD69177.1 - 4.1e-05 23.6 10.6 8.1e-05 22.7 10.6 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain L51_S25_CI-B8 PF05047.16 EMD69178.1 - 5.9e-15 54.9 0.0 7.6e-15 54.6 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain MPC PF03650.13 EMD69179.1 - 1.9e-48 163.2 0.2 2.5e-48 162.8 0.2 1.1 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers Zn_ribbon_17 PF17120.5 EMD69180.1 - 5.3e-15 54.8 12.3 9.3e-15 54.0 12.3 1.4 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type WD40 PF00400.32 EMD69180.1 - 2.3e-06 28.2 5.6 0.12 13.3 0.1 4.9 4 0 0 4 4 4 3 WD domain, G-beta repeat zf-RING_2 PF13639.6 EMD69180.1 - 0.7 10.3 5.7 1.4 9.3 5.7 1.5 1 0 0 1 1 1 0 Ring finger domain UQ_con PF00179.26 EMD69181.1 - 8.3e-49 164.8 0.0 9.4e-49 164.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EMD69181.1 - 0.00079 19.1 0.0 0.00095 18.9 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 EMD69181.1 - 0.022 14.6 0.0 0.048 13.5 0.0 1.7 1 1 0 1 1 1 0 UEV domain RWD PF05773.22 EMD69181.1 - 0.095 13.0 0.3 0.17 12.2 0.3 1.7 1 1 0 1 1 1 0 RWD domain Sugar_tr PF00083.24 EMD69184.1 - 2e-78 264.3 16.9 2.9e-78 263.8 16.9 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD69184.1 - 2.8e-18 66.0 37.0 1.2e-15 57.3 6.4 2.1 1 1 0 2 2 2 2 Major Facilitator Superfamily Bestrophin PF01062.21 EMD69185.1 - 1.5e-35 123.1 0.1 2.2e-35 122.5 0.1 1.1 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel SARS_lipid_bind PF09399.10 EMD69186.1 - 0.086 13.0 0.0 0.12 12.6 0.0 1.2 1 0 0 1 1 1 0 SARS lipid binding protein ABC_tran PF00005.27 EMD69187.1 - 1.9e-49 167.7 0.0 4.2e-26 92.1 0.0 3.6 2 2 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 EMD69187.1 - 2.1e-16 60.6 1.6 5.1e-05 23.2 0.0 4.4 3 1 0 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EMD69187.1 - 4.1e-14 52.6 0.2 0.00025 20.5 0.0 4.3 4 0 0 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EMD69187.1 - 2.8e-07 31.2 0.0 0.028 14.9 0.0 2.6 2 0 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.23 EMD69187.1 - 4.8e-07 29.8 0.0 0.0048 17.0 0.0 2.9 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_29 PF13555.6 EMD69187.1 - 1.9e-06 27.5 1.0 0.021 14.6 0.2 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EMD69187.1 - 3.5e-06 27.0 0.1 0.039 13.9 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_28 PF13521.6 EMD69187.1 - 1.7e-05 25.1 0.0 0.017 15.4 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EMD69187.1 - 4.3e-05 23.8 0.0 0.42 10.9 0.0 2.9 2 0 0 2 2 2 2 AAA domain Chromo PF00385.24 EMD69187.1 - 5.9e-05 22.9 0.1 0.00012 21.9 0.1 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain NACHT PF05729.12 EMD69187.1 - 0.00023 21.1 0.1 0.15 12.0 0.0 2.5 2 0 0 2 2 2 1 NACHT domain AAA_15 PF13175.6 EMD69187.1 - 0.00023 21.0 0.2 0.24 11.1 0.3 2.5 2 0 0 2 2 2 2 AAA ATPase domain DUF87 PF01935.17 EMD69187.1 - 0.0006 20.0 0.4 0.19 11.8 0.1 3.0 2 0 0 2 2 2 1 Helicase HerA, central domain AAA_18 PF13238.6 EMD69187.1 - 0.00086 19.9 0.1 1.2 9.7 0.0 3.0 3 0 0 3 3 2 1 AAA domain AAA_33 PF13671.6 EMD69187.1 - 0.002 18.3 0.0 3.1 8.0 0.0 2.8 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 EMD69187.1 - 0.0037 17.6 0.1 2.7 8.4 0.0 2.8 2 0 0 2 2 2 1 RNA helicase SbcCD_C PF13558.6 EMD69187.1 - 0.0039 17.4 0.0 1.6 9.0 0.0 3.2 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit MeaB PF03308.16 EMD69187.1 - 0.004 16.2 0.3 1 8.3 0.0 2.5 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB Dynamin_N PF00350.23 EMD69187.1 - 0.0054 16.8 0.0 0.16 12.0 0.0 2.8 2 1 0 2 2 2 1 Dynamin family AAA_13 PF13166.6 EMD69187.1 - 0.0077 14.9 0.0 1.6 7.3 0.0 2.3 2 0 0 2 2 2 1 AAA domain PduV-EutP PF10662.9 EMD69187.1 - 0.0087 15.8 0.0 0.41 10.4 0.0 3.0 3 0 0 3 3 2 1 Ethanolamine utilisation - propanediol utilisation AAA_16 PF13191.6 EMD69187.1 - 0.0094 16.3 0.0 2.9 8.2 0.0 3.0 2 0 0 2 2 2 1 AAA ATPase domain AAA_24 PF13479.6 EMD69187.1 - 0.0098 15.6 0.4 0.89 9.2 0.1 2.7 2 0 0 2 2 2 1 AAA domain DUF815 PF05673.13 EMD69187.1 - 0.011 14.9 0.6 0.29 10.3 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Roc PF08477.13 EMD69187.1 - 0.02 15.1 0.0 3 8.1 0.0 2.5 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_30 PF13604.6 EMD69187.1 - 0.024 14.3 0.8 7.8 6.2 0.0 3.2 4 0 0 4 4 2 0 AAA domain Septin PF00735.18 EMD69187.1 - 0.031 13.6 0.0 3.6 6.8 0.0 2.4 2 0 0 2 2 2 0 Septin HEAT PF02985.22 EMD69187.1 - 0.031 14.5 0.1 69 4.1 0.0 4.7 4 0 0 4 4 4 0 HEAT repeat SR-25 PF10500.9 EMD69187.1 - 0.032 13.8 1.1 0.062 12.9 1.1 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF3584 PF12128.8 EMD69187.1 - 0.034 11.7 1.3 2.1 5.8 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) AAA PF00004.29 EMD69187.1 - 0.035 14.5 0.0 12 6.4 0.0 3.4 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA_27 PF13514.6 EMD69187.1 - 0.038 13.6 0.0 8.8 5.9 0.0 2.5 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 EMD69187.1 - 0.043 13.0 0.0 3.3 6.8 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain AAA_14 PF13173.6 EMD69187.1 - 0.046 13.8 0.0 7.8 6.6 0.0 2.7 2 0 0 2 2 2 0 AAA domain Ploopntkinase3 PF18751.1 EMD69187.1 - 0.073 13.0 0.0 12 5.8 0.0 2.4 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 Zeta_toxin PF06414.12 EMD69187.1 - 0.075 12.3 2.0 1 8.6 0.1 2.7 3 0 0 3 3 3 0 Zeta toxin ATP-synt_ab PF00006.25 EMD69187.1 - 0.081 12.6 0.1 16 5.1 0.0 2.8 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain HEAT_2 PF13646.6 EMD69187.1 - 0.12 12.8 4.5 3 8.3 0.0 4.3 4 1 1 5 5 3 0 HEAT repeats TsaE PF02367.17 EMD69187.1 - 0.14 12.1 0.1 20 5.2 0.0 2.6 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Arf PF00025.21 EMD69187.1 - 0.17 11.4 0.3 1.6 8.1 0.0 2.6 3 0 0 3 3 3 0 ADP-ribosylation factor family MukB PF04310.12 EMD69187.1 - 0.19 11.5 0.3 24 4.7 0.0 2.3 2 0 0 2 2 2 0 MukB N-terminal zf-C2H2 PF00096.26 EMD69190.1 - 2.4e-09 37.2 10.3 0.00029 21.1 1.2 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMD69190.1 - 8.5e-06 26.0 10.8 1.6e-05 25.1 1.0 3.2 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMD69190.1 - 7.1e-05 23.3 9.4 0.098 13.5 1.8 2.9 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_6 PF13912.6 EMD69190.1 - 0.012 15.6 0.9 0.012 15.6 0.9 2.1 2 0 0 2 2 2 0 C2H2-type zinc finger zf-met PF12874.7 EMD69190.1 - 0.057 13.8 7.8 0.077 13.4 1.8 3.7 3 0 0 3 3 3 0 Zinc-finger of C2H2 type Zn-ribbon_8 PF09723.10 EMD69190.1 - 0.29 11.3 2.6 4.9 7.4 0.3 2.4 1 1 1 2 2 2 0 Zinc ribbon domain zf-C2H2_jaz PF12171.8 EMD69190.1 - 0.39 11.1 3.9 0.42 10.9 0.3 2.4 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Zn_ribbon_SprT PF17283.2 EMD69190.1 - 0.42 10.6 6.3 0.3 11.0 1.4 2.3 1 1 1 2 2 2 0 SprT-like zinc ribbon domain Rpr2 PF04032.16 EMD69190.1 - 2 8.7 6.3 0.48 10.7 0.5 2.5 2 0 0 2 2 2 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain Presenilin PF01080.17 EMD69190.1 - 7.1 5.3 9.6 9.1 4.9 9.6 1.3 1 0 0 1 1 1 0 Presenilin Pyrid_oxidase_2 PF13883.6 EMD69191.1 - 7.8e-51 172.4 0.0 9.6e-51 172.1 0.0 1.1 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Ribosomal_S30 PF04758.14 EMD69192.1 - 1.4e-29 102.0 8.5 1.5e-29 101.9 8.5 1.0 1 0 0 1 1 1 1 Ribosomal protein S30 DUF1687 PF07955.11 EMD69193.1 - 4.4e-28 98.3 0.0 6.7e-28 97.7 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1687) ArsC PF03960.15 EMD69193.1 - 0.11 12.6 0.0 0.23 11.5 0.0 1.6 1 0 0 1 1 1 0 ArsC family Mus7 PF09462.10 EMD69195.1 - 6.1e-126 421.8 0.9 8.5e-126 421.3 0.9 1.2 1 0 0 1 1 1 1 Mus7/MMS22 family Glyco_hydro_36 PF17167.4 EMD69195.1 - 0.077 11.7 0.0 0.13 10.9 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase 36 superfamily, catalytic domain PPTA PF01239.22 EMD69196.1 - 3.5e-42 140.9 23.6 6.3e-09 35.3 0.1 6.1 6 0 0 6 6 6 5 Protein prenyltransferase alpha subunit repeat DUF4003 PF13170.6 EMD69196.1 - 0.021 14.2 0.8 1.2 8.4 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4003) DUF3950 PF13132.6 EMD69196.1 - 0.023 14.4 0.6 3.5 7.5 0.2 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3950) ANAPC4_WD40 PF12894.7 EMD69197.1 - 5.5e-09 36.2 0.0 0.067 13.5 0.0 4.4 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EMD69197.1 - 0.016 16.1 10.0 0.54 11.2 0.0 4.9 7 0 0 7 7 7 0 WD domain, G-beta repeat Ribosomal_S6e PF01092.19 EMD69198.1 - 7.2e-59 197.2 0.0 1.2e-58 196.5 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S6e Calcipressin PF04847.12 EMD69199.1 - 1.9e-43 148.4 0.3 2.6e-43 147.9 0.3 1.1 1 0 0 1 1 1 1 Calcipressin RRM_1 PF00076.22 EMD69199.1 - 0.094 12.5 0.1 0.2 11.5 0.0 1.7 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNA_pol_A_bac PF01000.26 EMD69200.1 - 1.5e-31 109.1 0.0 2.4e-31 108.4 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 EMD69200.1 - 8.4e-16 57.2 0.0 1.1e-15 56.8 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain GrpE PF01025.19 EMD69201.1 - 1.1e-47 161.8 4.4 1.4e-47 161.4 4.4 1.1 1 0 0 1 1 1 1 GrpE DUF641 PF04859.12 EMD69201.1 - 0.004 17.5 0.9 0.013 15.8 0.8 1.9 2 0 0 2 2 2 1 Plant protein of unknown function (DUF641) DUF4201 PF13870.6 EMD69201.1 - 0.0086 15.8 3.8 0.015 15.0 3.7 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF4201) PKcGMP_CC PF16808.5 EMD69201.1 - 0.025 14.4 2.3 0.069 13.0 2.3 1.8 1 0 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Ofd1_CTDD PF10637.9 EMD69201.1 - 0.03 13.7 0.2 0.032 13.6 0.2 1.1 1 0 0 1 1 1 0 Oxoglutarate and iron-dependent oxygenase degradation C-term PEARLI-4 PF05278.12 EMD69201.1 - 0.042 13.4 1.7 0.062 12.9 1.7 1.2 1 0 0 1 1 1 0 Arabidopsis phospholipase-like protein (PEARLI 4) TMF_DNA_bd PF12329.8 EMD69201.1 - 0.073 13.1 10.3 0.19 11.7 10.3 1.7 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding Seryl_tRNA_N PF02403.22 EMD69201.1 - 0.22 11.8 7.7 0.29 11.4 6.6 1.8 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Fez1 PF06818.15 EMD69201.1 - 1.5 9.3 8.5 0.077 13.5 3.2 1.6 2 0 0 2 2 2 0 Fez1 PrpF PF04303.13 EMD69202.1 - 5.9e-90 301.9 0.9 1.6e-74 251.1 0.3 2.1 2 0 0 2 2 2 2 PrpF protein TFB6 PF17110.5 EMD69202.1 - 0.015 15.1 0.5 0.015 15.1 0.5 2.0 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH Pribosyltran_N PF13793.6 EMD69204.1 - 6.5e-45 151.8 0.0 8.4e-44 148.2 0.0 2.4 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 EMD69204.1 - 6.5e-44 150.2 0.5 5.7e-37 127.5 0.4 2.4 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 EMD69204.1 - 3.7e-16 59.0 1.1 5.8e-15 55.2 0.7 2.2 2 0 0 2 2 2 1 Phosphoribosyl transferase domain UPRTase PF14681.6 EMD69204.1 - 0.0011 18.5 0.1 0.0021 17.5 0.1 1.4 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Uds1 PF15456.6 EMD69205.1 - 5.1e-30 104.3 6.0 9.3e-30 103.5 6.0 1.4 1 0 0 1 1 1 1 Up-regulated During Septation APG6_N PF17675.1 EMD69205.1 - 0.014 15.9 1.9 0.024 15.2 1.9 1.3 1 0 0 1 1 1 0 Apg6 coiled-coil region Stathmin PF00836.19 EMD69205.1 - 0.016 15.2 1.0 0.016 15.2 1.0 2.2 2 1 0 2 2 2 0 Stathmin family TMF_TATA_bd PF12325.8 EMD69205.1 - 0.43 10.8 3.2 0.83 9.9 3.2 1.4 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding tRNA-synt_2d PF01409.20 EMD69207.1 - 8.1e-47 159.8 0.0 1.2e-26 93.7 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) FDX-ACB PF03147.14 EMD69207.1 - 2e-23 82.6 0.0 2.6e-22 79.0 0.0 2.5 1 1 0 1 1 1 1 Ferredoxin-fold anticodon binding domain Mito_carr PF00153.27 EMD69208.1 - 4.5e-57 190.0 3.0 9.2e-21 73.6 0.3 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF4458 PF14660.6 EMD69208.1 - 0.078 13.2 0.0 0.24 11.6 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4458) adh_short PF00106.25 EMD69209.1 - 7.9e-25 87.5 0.0 3.3e-23 82.2 0.0 2.0 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD69209.1 - 2.9e-14 53.2 0.0 3.6e-13 49.6 0.0 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD69209.1 - 6.4e-12 45.7 0.0 1.2e-11 44.9 0.0 1.4 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EMD69209.1 - 1e-06 28.4 0.1 1.4e-06 28.0 0.1 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EMD69209.1 - 0.0033 16.6 0.0 0.0041 16.3 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Sacchrp_dh_NADP PF03435.18 EMD69209.1 - 0.057 13.7 0.0 0.092 13.0 0.0 1.3 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain GH131_N PF18271.1 EMD69212.1 - 4.8e-51 173.9 0.0 5.5e-51 173.7 0.0 1.0 1 0 0 1 1 1 1 Glycoside hydrolase 131 catalytic N-terminal domain ZapA PF05164.13 EMD69212.1 - 0.11 12.9 0.0 0.21 12.0 0.0 1.5 1 1 0 1 1 1 0 Cell division protein ZapA Ank_2 PF12796.7 EMD69213.1 - 8.1e-21 74.4 0.0 3.6e-11 43.5 0.0 2.9 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMD69213.1 - 5.1e-14 52.4 0.2 2.5e-07 31.1 0.0 3.5 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMD69213.1 - 1.5e-13 49.6 0.0 0.00043 20.5 0.0 4.3 4 0 0 4 4 4 3 Ankyrin repeat HET PF06985.11 EMD69213.1 - 4.4e-12 46.6 5.8 2.6e-09 37.6 0.1 3.2 3 1 1 4 4 4 2 Heterokaryon incompatibility protein (HET) Ank PF00023.30 EMD69213.1 - 1.7e-09 37.7 0.9 0.012 16.0 0.1 4.0 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 EMD69213.1 - 1.1e-08 35.2 0.3 0.0024 18.1 0.0 3.3 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 EMD69214.1 - 1.1e-26 93.2 0.0 8.9e-16 58.3 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EMD69214.1 - 1.1e-17 63.9 0.0 1.3e-10 41.3 0.1 2.2 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMD69214.1 - 1.2e-16 59.0 0.0 2.6e-05 24.3 0.0 3.4 4 0 0 4 4 4 3 Ankyrin repeat Ank_4 PF13637.6 EMD69214.1 - 1.4e-14 54.2 0.0 1.6e-12 47.7 0.0 2.5 2 1 1 3 3 3 1 Ankyrin repeats (many copies) Ank PF00023.30 EMD69214.1 - 4.6e-14 52.1 0.0 8.5e-05 22.8 0.0 3.5 4 0 0 4 4 4 3 Ankyrin repeat DUF2384 PF09722.10 EMD69214.1 - 0.06 13.4 0.0 15 5.7 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2384) Neil1-DNA_bind PF09292.10 EMD69214.1 - 0.43 10.6 2.1 9.7 6.3 0.1 3.0 3 0 0 3 3 3 0 Endonuclease VIII-like 1, DNA bind Rad21_Rec8_N PF04825.13 EMD69215.1 - 7.4e-32 109.8 0.0 1.4e-31 108.9 0.0 1.4 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein PRR20 PF15708.5 EMD69215.1 - 0.048 13.6 1.2 0.098 12.6 0.4 1.8 2 0 0 2 2 2 0 Proline-rich protein family 20 Clathrin-link PF09268.10 EMD69215.1 - 0.059 12.8 0.3 0.059 12.8 0.3 1.9 2 0 0 2 2 2 0 Clathrin, heavy-chain linker Rad21_Rec8 PF04824.16 EMD69215.1 - 0.065 12.5 0.0 0.13 11.5 0.0 1.6 1 0 0 1 1 1 0 Conserved region of Rad21 / Rec8 like protein Pneumo_phosprot PF02478.16 EMD69215.1 - 0.092 12.3 0.8 0.18 11.3 0.8 1.4 1 0 0 1 1 1 0 Pneumovirus phosphoprotein UCH PF00443.29 EMD69216.1 - 2.4e-52 178.0 0.1 3.2e-52 177.6 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EMD69216.1 - 7e-14 52.1 6.6 1.4e-13 51.2 5.3 2.2 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.23 EMD69216.1 - 4e-13 48.9 0.9 8.4e-13 47.9 0.2 2.0 2 0 0 2 2 2 1 Ubiquitin family ARPC4 PF05856.12 EMD69217.1 - 7.3e-79 263.2 4.2 8.2e-79 263.0 4.2 1.0 1 0 0 1 1 1 1 ARP2/3 complex 20 kDa subunit (ARPC4) DUF1902 PF08972.11 EMD69217.1 - 0.1 12.6 0.0 0.2 11.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1902) Redoxin PF08534.10 EMD69218.1 - 7.8e-36 123.0 0.0 8.7e-36 122.8 0.0 1.0 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 EMD69218.1 - 8.8e-09 35.3 0.0 1e-08 35.1 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family DUF1348 PF07080.11 EMD69219.1 - 2e-60 202.4 6.0 2.4e-60 202.2 6.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1348) SnoaL_2 PF12680.7 EMD69219.1 - 4.8e-06 27.1 0.1 6.9e-06 26.7 0.1 1.3 1 0 0 1 1 1 1 SnoaL-like domain DUF4440 PF14534.6 EMD69219.1 - 0.0039 17.6 0.0 0.0062 16.9 0.0 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF4440) Robl_LC7 PF03259.17 EMD69220.1 - 4.7e-10 39.1 0.0 3.1e-07 30.1 0.0 2.1 2 0 0 2 2 2 2 Roadblock/LC7 domain Ipi1_N PF12333.8 EMD69221.1 - 4.5e-27 94.6 0.3 4.5e-27 94.6 0.3 2.2 3 0 0 3 3 3 1 Rix1 complex component involved in 60S ribosome maturation Mpv17_PMP22 PF04117.12 EMD69222.1 - 9.8e-13 48.1 1.2 2.2e-12 47.0 1.2 1.6 1 0 0 1 1 1 1 Mpv17 / PMP22 family Glyco_hydro_16 PF00722.21 EMD69223.1 - 2.2e-12 46.8 0.8 3.6e-12 46.1 0.8 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 ATPase_gene1 PF09527.10 EMD69223.1 - 0.019 15.1 0.8 0.21 11.8 0.1 2.3 2 0 0 2 2 2 0 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter Ala_racemase_N PF01168.20 EMD69224.1 - 3.4e-27 95.5 0.2 4.1e-27 95.2 0.2 1.1 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain D-ser_dehydrat PF14031.6 EMD69224.1 - 1.3e-21 77.0 0.1 3.8e-21 75.5 0.0 1.8 2 0 0 2 2 2 1 Putative serine dehydratase domain Glyco_transf_4 PF13439.6 EMD69224.1 - 0.02 14.9 0.0 0.041 13.9 0.0 1.5 1 0 0 1 1 1 0 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 EMD69224.1 - 0.13 12.7 0.5 0.44 11.0 0.0 1.9 2 0 0 2 2 2 0 Glycosyl transferase 4-like domain DUF1533 PF07550.11 EMD69224.1 - 0.2 11.6 0.1 0.72 9.8 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1533) Aminotran_3 PF00202.21 EMD69226.1 - 1.1e-112 376.6 0.0 1.4e-112 376.3 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 EMD69226.1 - 3.8e-06 26.3 0.0 7.9e-06 25.3 0.0 1.4 1 1 0 1 1 1 1 Aminotransferase class I and II SNF2_N PF00176.23 EMD69227.1 - 2.3e-41 141.7 0.0 1.6e-38 132.3 0.0 2.2 2 0 0 2 2 2 2 SNF2 family N-terminal domain Helicase_C PF00271.31 EMD69227.1 - 8.4e-05 22.9 0.0 0.00021 21.6 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain adh_short PF00106.25 EMD69229.1 - 4.7e-27 94.7 1.6 2.8e-15 56.3 0.1 3.1 2 1 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EMD69229.1 - 1.2e-21 77.4 1.0 8e-11 41.9 0.0 2.9 3 0 0 3 3 3 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD69229.1 - 3.9e-05 23.7 0.0 6.1e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 KR domain ADH_zinc_N_2 PF13602.6 EMD69229.1 - 0.095 13.8 0.0 0.36 11.9 0.0 1.9 1 1 0 1 1 1 0 Zinc-binding dehydrogenase ABC_membrane_2 PF06472.15 EMD69230.1 - 3.4e-104 348.0 0.9 5.2e-104 347.4 0.9 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 EMD69230.1 - 1.9e-17 64.1 0.0 3.7e-17 63.1 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 EMD69230.1 - 5.1e-05 23.2 0.0 0.00027 20.8 0.0 2.0 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system Reticulon PF02453.17 EMD69230.1 - 0.0037 17.2 0.1 0.0081 16.1 0.1 1.5 1 0 0 1 1 1 1 Reticulon AAA_23 PF13476.6 EMD69230.1 - 0.0069 16.9 0.0 0.015 15.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 EMD69230.1 - 0.021 14.5 0.0 0.067 12.9 0.0 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.6 EMD69230.1 - 0.031 14.7 0.7 0.49 10.8 0.0 2.6 3 0 0 3 3 3 0 AAA ATPase domain SMC_N PF02463.19 EMD69230.1 - 0.044 13.2 0.3 0.16 11.4 0.0 2.0 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain RuvB_N PF05496.12 EMD69230.1 - 0.049 13.4 0.0 0.39 10.5 0.0 2.4 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain Rad17 PF03215.15 EMD69230.1 - 0.059 13.3 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain Mg_chelatase PF01078.21 EMD69230.1 - 0.18 11.2 0.0 0.49 9.7 0.0 1.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI FMO-like PF00743.19 EMD69231.1 - 1.9e-12 46.4 0.1 1.2e-11 43.7 0.0 2.1 2 0 0 2 2 2 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EMD69231.1 - 4.7e-09 35.9 0.0 4.9e-08 32.6 0.0 2.3 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EMD69231.1 - 2.4e-08 34.1 0.0 7.6e-08 32.5 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 EMD69231.1 - 3.2e-07 29.8 0.1 6.4e-06 25.5 0.0 2.7 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.14 EMD69231.1 - 7.1e-07 28.7 0.0 1.9e-05 24.1 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase WD40 PF00400.32 EMD69231.1 - 4.8e-05 24.0 0.1 9.1 7.3 0.1 5.2 4 0 0 4 4 4 1 WD domain, G-beta repeat LisH PF08513.11 EMD69231.1 - 0.00035 20.4 0.2 0.00073 19.4 0.2 1.5 1 0 0 1 1 1 1 LisH NAD_binding_9 PF13454.6 EMD69231.1 - 0.0026 17.8 0.1 0.16 11.9 0.0 2.7 2 1 1 3 3 3 1 FAD-NAD(P)-binding Thi4 PF01946.17 EMD69231.1 - 0.02 14.1 0.0 0.084 12.1 0.0 2.0 3 0 0 3 3 3 0 Thi4 family eIF2A PF08662.11 EMD69231.1 - 0.02 14.8 0.1 0.51 10.2 0.1 2.4 2 0 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A HI0933_like PF03486.14 EMD69231.1 - 0.044 12.5 0.1 0.087 11.5 0.1 1.4 1 0 0 1 1 1 0 HI0933-like protein DAO PF01266.24 EMD69231.1 - 0.074 12.6 1.3 26 4.3 0.3 3.4 3 1 1 4 4 4 0 FAD dependent oxidoreductase DUF1751 PF08551.10 EMD69232.1 - 7.3e-26 90.6 2.0 7.3e-26 90.6 2.0 1.7 2 0 0 2 2 2 1 Eukaryotic integral membrane protein (DUF1751) Rhomboid PF01694.22 EMD69232.1 - 3.5 7.6 11.4 6.9 6.7 11.4 1.5 1 1 0 1 1 1 0 Rhomboid family GATase_6 PF13522.6 EMD69233.1 - 1.2e-14 54.6 0.0 3.2e-14 53.3 0.0 1.7 2 0 0 2 2 2 1 Glutamine amidotransferase domain GATase_7 PF13537.6 EMD69233.1 - 1.7e-11 44.1 0.0 3.5e-11 43.1 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain Pribosyltran PF00156.27 EMD69233.1 - 5.9e-06 25.9 0.0 1.3e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 Phosphoribosyl transferase domain GATase_4 PF13230.6 EMD69233.1 - 0.038 12.9 0.0 0.071 12.0 0.0 1.4 1 0 0 1 1 1 0 Glutamine amidotransferases class-II Ctf8 PF09696.10 EMD69236.1 - 5.5e-39 133.7 0.0 3.2e-38 131.3 0.0 1.8 1 1 0 1 1 1 1 Ctf8 CBM_1 PF00734.18 EMD69237.1 - 2.1e-11 43.6 11.2 2.1e-11 43.6 11.2 2.5 3 0 0 3 3 3 1 Fungal cellulose binding domain DEC-1_N PF04625.13 EMD69237.1 - 3.1 6.7 4.5 4 6.4 4.5 1.2 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region polyprenyl_synt PF00348.17 EMD69239.1 - 7.2e-26 90.8 0.0 7.9e-19 67.7 0.0 2.2 1 1 1 2 2 2 2 Polyprenyl synthetase adh_short_C2 PF13561.6 EMD69240.1 - 9.6e-12 45.0 0.0 2.5e-11 43.6 0.0 1.6 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EMD69240.1 - 8.1e-11 41.7 0.0 7e-05 22.4 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase KR PF08659.10 EMD69240.1 - 0.0021 18.0 0.0 0.0047 16.9 0.0 1.6 2 0 0 2 2 2 1 KR domain DUF4160 PF13711.6 EMD69241.1 - 0.16 12.3 0.5 0.49 10.7 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4160) Zn_clus PF00172.18 EMD69244.1 - 3.9e-08 33.3 6.4 5.6e-08 32.8 6.4 1.2 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF2461 PF09365.10 EMD69245.1 - 1.1e-76 257.4 0.1 1.6e-76 256.9 0.1 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein (DUF2461) MSP1_C PF07462.11 EMD69245.1 - 0.36 9.5 5.6 0.51 9.0 5.6 1.2 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus DUF4611 PF15387.6 EMD69245.1 - 9.5 6.5 18.6 1.9 8.7 0.5 3.5 2 1 1 3 3 3 0 Domain of unknown function (DUF4611) TYW3 PF02676.14 EMD69246.1 - 9.5e-72 240.8 0.0 1.3e-71 240.4 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase TYW3 Methyltransf_23 PF13489.6 EMD69247.1 - 1.7e-15 57.3 0.0 2.9e-15 56.5 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMD69247.1 - 1.6e-11 44.7 0.0 3.7e-11 43.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMD69247.1 - 3.2e-11 43.8 0.0 7.8e-11 42.5 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMD69247.1 - 6.3e-11 42.9 0.0 1.3e-10 41.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMD69247.1 - 3.2e-08 33.5 0.0 4.8e-08 32.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EMD69247.1 - 5.1e-07 29.3 0.0 3.2e-06 26.6 0.0 2.2 2 1 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_24 PF13578.6 EMD69247.1 - 0.028 15.4 0.1 0.065 14.3 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase domain Chorion_2 PF03964.15 EMD69247.1 - 0.085 13.7 5.1 0.16 12.8 5.1 1.4 1 0 0 1 1 1 0 Chorion family 2 DREV PF05219.12 EMD69247.1 - 0.12 11.4 0.0 0.19 10.8 0.0 1.2 1 0 0 1 1 1 0 DREV methyltransferase RrnaAD PF00398.20 EMD69247.1 - 0.13 11.3 0.0 0.18 10.8 0.0 1.1 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase SelP_N PF04592.14 EMD69247.1 - 0.14 11.5 13.9 0.21 10.9 13.9 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Glyco_hydro_3_C PF01915.22 EMD69248.1 - 5.3e-48 163.7 0.0 9.4e-48 162.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 EMD69248.1 - 4.1e-39 134.8 0.0 6.6e-39 134.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 EMD69248.1 - 2.1e-23 82.2 0.2 3.9e-23 81.3 0.2 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain Citrate_synt PF00285.21 EMD69249.1 - 6.6e-98 328.1 0.0 8.4e-98 327.8 0.0 1.1 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain Bact_lectin PF18483.1 EMD69249.1 - 0.089 12.8 0.0 0.14 12.2 0.0 1.2 1 0 0 1 1 1 0 Bacterial lectin ICL PF00463.21 EMD69250.1 - 2.7e-192 639.9 0.1 3.2e-192 639.7 0.1 1.0 1 0 0 1 1 1 1 Isocitrate lyase family PEP_mutase PF13714.6 EMD69250.1 - 1.7e-07 31.0 0.0 1.8e-06 27.6 0.0 2.2 1 1 0 2 2 2 1 Phosphoenolpyruvate phosphomutase DUF726 PF05277.12 EMD69251.1 - 3.1e-128 427.5 0.2 4.5e-128 427.0 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF726) Pex14_N PF04695.13 EMD69251.1 - 5.2e-35 121.4 0.1 5.2e-35 121.4 0.1 5.1 6 1 1 7 7 7 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Thioesterase PF00975.20 EMD69251.1 - 0.0027 17.9 0.0 0.011 15.8 0.0 2.0 1 0 0 1 1 1 1 Thioesterase domain Abhydrolase_1 PF00561.20 EMD69251.1 - 0.076 12.6 0.0 0.17 11.5 0.0 1.5 1 0 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EMD69251.1 - 0.19 12.3 1.0 0.99 10.0 0.0 2.3 1 1 0 2 2 2 0 Alpha/beta hydrolase family Phage_holin_3_6 PF07332.11 EMD69251.1 - 0.56 10.3 6.9 2.4 8.2 6.9 2.1 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III GRA6 PF05084.13 EMD69252.1 - 0.029 14.3 0.1 0.052 13.5 0.1 1.3 1 0 0 1 1 1 0 Granule antigen protein (GRA6) Gram_pos_anchor PF00746.21 EMD69252.1 - 0.056 13.4 0.4 0.14 12.1 0.4 1.7 1 0 0 1 1 1 0 LPXTG cell wall anchor motif SKG6 PF08693.10 EMD69252.1 - 0.12 11.8 0.1 0.22 10.9 0.1 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain VSP PF03302.13 EMD69252.1 - 0.18 10.6 0.1 0.28 10.0 0.1 1.2 1 0 0 1 1 1 0 Giardia variant-specific surface protein AMP-binding PF00501.28 EMD69253.1 - 5.3e-88 295.4 0.1 6.6e-88 295.1 0.1 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EMD69253.1 - 4e-27 95.0 0.6 1.1e-25 90.4 0.8 2.6 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain ACAS_N PF16177.5 EMD69253.1 - 3.4e-19 68.5 0.2 1.3e-18 66.6 0.2 2.1 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus Reprolysin_5 PF13688.6 EMD69254.1 - 1.3e-58 198.4 10.0 1.3e-58 198.4 10.0 2.5 2 1 0 2 2 2 1 Metallo-peptidase family M12 Reprolysin_2 PF13574.6 EMD69254.1 - 2e-46 158.3 5.5 4.3e-46 157.3 5.5 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 EMD69254.1 - 4.9e-44 150.4 5.2 8.2e-44 149.7 5.2 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Disintegrin PF00200.23 EMD69254.1 - 2.5e-16 60.2 31.3 2.5e-16 60.2 31.3 4.5 4 1 0 4 4 4 1 Disintegrin Reprolysin_3 PF13582.6 EMD69254.1 - 6.3e-12 46.1 0.8 1.6e-11 44.8 0.3 2.0 2 0 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like ADAM_CR_2 PF17771.1 EMD69254.1 - 0.00043 20.7 10.7 0.00043 20.7 10.7 4.8 1 1 2 3 3 3 1 ADAM cysteine-rich domain Pep_M12B_propep PF01562.19 EMD69254.1 - 0.023 14.9 0.0 0.068 13.4 0.0 1.8 1 0 0 1 1 1 0 Reprolysin family propeptide LapA_dom PF06305.11 EMD69254.1 - 0.089 12.6 0.4 0.19 11.5 0.4 1.5 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain NmrA PF05368.13 EMD69255.1 - 5.1e-12 45.9 0.0 6.7e-12 45.5 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EMD69255.1 - 9.2e-09 35.4 0.0 1.5e-08 34.8 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding NACHT PF05729.12 EMD69257.1 - 3.7e-12 46.5 0.0 4.6e-12 46.2 0.0 1.1 1 0 0 1 1 1 1 NACHT domain AFG1_ATPase PF03969.16 EMD69257.1 - 0.0039 16.1 0.0 0.0045 15.9 0.0 1.1 1 0 0 1 1 1 1 AFG1-like ATPase RNA_helicase PF00910.22 EMD69257.1 - 0.0053 17.1 0.0 0.0091 16.4 0.0 1.4 1 0 0 1 1 1 1 RNA helicase AAA_19 PF13245.6 EMD69257.1 - 0.012 16.0 0.0 0.014 15.7 0.0 1.2 1 0 0 1 1 1 0 AAA domain Ploopntkinase3 PF18751.1 EMD69257.1 - 0.014 15.3 0.0 0.02 14.8 0.0 1.2 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 DUF2075 PF09848.9 EMD69257.1 - 0.017 14.3 0.0 0.02 14.1 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) NB-ARC PF00931.22 EMD69257.1 - 0.028 13.6 0.1 0.071 12.3 0.0 1.5 1 1 0 2 2 2 0 NB-ARC domain ResIII PF04851.15 EMD69257.1 - 0.029 14.4 0.0 0.034 14.2 0.0 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_35 PF14516.6 EMD69257.1 - 0.035 13.0 0.1 0.041 12.7 0.1 1.1 1 0 0 1 1 1 0 AAA-like domain AAA_11 PF13086.6 EMD69257.1 - 0.041 13.7 0.0 0.046 13.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 EMD69257.1 - 0.12 12.4 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DnaB_C PF03796.15 EMD69257.1 - 0.15 11.4 0.0 0.17 11.2 0.0 1.1 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain TIP49 PF06068.13 EMD69257.1 - 0.16 11.2 0.0 0.34 10.1 0.0 1.4 1 1 0 1 1 1 0 TIP49 P-loop domain Zn_clus PF00172.18 EMD69258.1 - 3e-07 30.5 10.2 5e-07 29.7 10.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EMD69258.1 - 0.00032 19.8 1.4 0.0005 19.2 1.4 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain DLH PF01738.18 EMD69259.1 - 2.5e-17 63.2 0.0 3e-17 62.9 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_1 PF00561.20 EMD69259.1 - 0.0014 18.3 0.0 0.0019 17.9 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold BTB PF00651.31 EMD69260.1 - 1.2e-24 86.6 0.2 7.8e-12 45.4 0.2 2.4 2 0 0 2 2 2 2 BTB/POZ domain Ank_4 PF13637.6 EMD69260.1 - 6.1e-08 33.1 0.1 1.7e-07 31.6 0.1 1.8 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 EMD69260.1 - 9.7e-08 32.1 0.0 3.5e-07 30.4 0.0 2.0 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EMD69260.1 - 1.2e-07 32.2 0.1 3.2e-07 30.8 0.1 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 EMD69260.1 - 2e-07 31.2 0.1 0.0028 18.1 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.6 EMD69260.1 - 6.1e-06 26.2 0.4 0.019 15.5 0.1 3.6 3 0 0 3 3 3 2 Ankyrin repeat DUF3342 PF11822.8 EMD69260.1 - 0.043 14.0 0.0 0.17 12.1 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3342) Pkinase PF00069.25 EMD69261.1 - 1.5e-56 191.7 0.1 6.2e-34 117.6 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EMD69261.1 - 2.7e-34 118.6 0.0 2.3e-33 115.6 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EMD69261.1 - 0.02 14.2 0.0 0.037 13.3 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Pkinase_fungal PF17667.1 EMD69261.1 - 0.038 12.8 0.4 0.14 10.9 0.0 1.9 2 0 0 2 2 2 0 Fungal protein kinase APH PF01636.23 EMD69261.1 - 0.26 11.2 2.5 0.6 10.0 0.0 2.5 3 0 0 3 3 3 0 Phosphotransferase enzyme family DUF3896 PF13035.6 EMD69261.1 - 0.3 11.3 3.3 0.23 11.6 0.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3896) Macoilin PF09726.9 EMD69261.1 - 0.4 9.2 4.3 0.83 8.1 4.3 1.4 1 0 0 1 1 1 0 Macoilin family Ferric_reduct PF01794.19 EMD69262.1 - 4e-21 75.4 11.6 8.9e-21 74.3 11.6 1.6 1 0 0 1 1 1 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 EMD69262.1 - 5.9e-19 68.2 0.0 1.7e-18 66.7 0.0 1.8 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.12 EMD69262.1 - 1.2e-18 67.7 0.0 9e-18 64.9 0.0 2.1 1 1 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_6 PF00970.24 EMD69262.1 - 0.0083 16.5 0.0 0.018 15.4 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain Ctr PF04145.15 EMD69263.1 - 5.6e-32 111.4 1.0 6.9e-32 111.1 1.0 1.1 1 0 0 1 1 1 1 Ctr copper transporter family DUF456 PF04306.13 EMD69263.1 - 0.11 12.8 6.7 0.12 12.7 1.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF456) NAC PF01849.18 EMD69265.1 - 3.3e-24 84.6 0.1 5.4e-24 83.9 0.1 1.4 1 0 0 1 1 1 1 NAC domain Med17 PF10156.9 EMD69265.1 - 0.024 13.4 0.3 0.025 13.3 0.3 1.1 1 0 0 1 1 1 0 Subunit 17 of Mediator complex Sigma70_ner PF04546.13 EMD69265.1 - 1.9 8.4 7.6 0.73 9.7 4.5 1.7 2 0 0 2 2 2 0 Sigma-70, non-essential region Pyr_redox_2 PF07992.14 EMD69266.1 - 2.1e-23 83.0 0.0 2.6e-23 82.7 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EMD69266.1 - 0.00026 20.4 0.0 0.00072 18.9 0.0 1.8 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EMD69266.1 - 0.00042 20.8 0.1 0.21 12.2 0.2 2.9 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DUF1899 PF08953.11 EMD69266.1 - 0.074 12.9 0.0 5.8 6.9 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF1899) RNase_PH PF01138.21 EMD69267.1 - 9e-19 68.3 0.0 1.4e-18 67.7 0.0 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 DUF1996 PF09362.10 EMD69268.1 - 3.9e-63 213.6 1.2 6.7e-63 212.8 1.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1996) AMP-binding PF00501.28 EMD69269.1 - 2.5e-67 227.3 0.0 3.4e-67 226.9 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EMD69269.1 - 1.7e-05 25.7 0.1 0.00015 22.7 0.0 2.3 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain PCP_red PF08369.10 EMD69269.1 - 0.1 12.8 0.0 0.31 11.3 0.0 1.8 1 1 0 1 1 1 0 Proto-chlorophyllide reductase 57 kD subunit Dynamin_M PF01031.20 EMD69270.1 - 7.7e-16 58.1 0.0 1.7e-15 57.0 0.0 1.6 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.23 EMD69270.1 - 9.8e-15 55.0 3.5 1.4e-13 51.3 0.1 2.7 2 1 1 3 3 3 2 Dynamin family cobW PF02492.19 EMD69271.1 - 3.1e-33 114.9 0.0 4e-33 114.5 0.0 1.2 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain MeaB PF03308.16 EMD69271.1 - 2.4e-07 30.0 0.1 6.9e-05 21.9 0.0 2.1 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB MMR_HSR1 PF01926.23 EMD69271.1 - 0.0027 17.8 0.0 0.0067 16.5 0.0 1.8 2 1 0 2 2 2 1 50S ribosome-binding GTPase AAA_18 PF13238.6 EMD69271.1 - 0.047 14.2 0.0 0.08 13.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain ResIII PF04851.15 EMD69271.1 - 0.096 12.7 0.0 0.14 12.1 0.0 1.4 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit AAA PF00004.29 EMD69271.1 - 0.12 12.8 0.0 0.2 12.1 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) TIP49 PF06068.13 EMD69271.1 - 0.13 11.4 0.0 0.2 10.8 0.0 1.2 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_16 PF13191.6 EMD69271.1 - 0.14 12.5 0.0 0.2 12.0 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain zf-C2H2_4 PF13894.6 EMD69272.1 - 0.53 11.3 7.5 0.33 11.9 0.7 3.0 2 0 0 2 2 2 0 C2H2-type zinc finger Fer4_2 PF12797.7 EMD69272.1 - 4.8 7.5 8.6 0.31 11.2 0.5 3.1 3 0 0 3 3 3 0 4Fe-4S binding domain KAR9 PF08580.10 EMD69273.1 - 4.5 5.7 16.1 5.5 5.4 16.1 1.0 1 0 0 1 1 1 0 Yeast cortical protein KAR9 NAD_binding_4 PF07993.12 EMD69274.1 - 4.8e-68 229.1 0.0 9.3e-68 228.2 0.0 1.5 1 0 0 1 1 1 1 Male sterility protein AMP-binding PF00501.28 EMD69274.1 - 8.9e-67 225.5 0.0 1.2e-66 225.0 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme PP-binding PF00550.25 EMD69274.1 - 2.2e-09 37.6 0.0 6.3e-09 36.1 0.0 1.9 1 0 0 1 1 1 1 Phosphopantetheine attachment site Epimerase PF01370.21 EMD69274.1 - 1.6e-07 31.1 0.0 3.6e-07 29.9 0.0 1.6 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family AMP-binding_C PF13193.6 EMD69274.1 - 8.3e-06 26.7 0.0 3.1e-05 24.9 0.0 2.1 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain 3Beta_HSD PF01073.19 EMD69274.1 - 4.4e-05 22.6 0.0 9.4e-05 21.5 0.0 1.5 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 EMD69274.1 - 0.0021 18.0 0.0 0.028 14.3 0.0 2.8 2 1 0 2 2 2 1 NAD(P)H-binding IBR PF01485.21 EMD69276.1 - 2.7e-08 33.9 20.1 2.9e-05 24.2 6.7 2.4 2 0 0 2 2 2 2 IBR domain, a half RING-finger domain Ank_4 PF13637.6 EMD69277.1 - 0.0059 17.2 0.0 0.053 14.1 0.0 2.3 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Glyco_hydro_76 PF03663.14 EMD69278.1 - 4.7e-154 513.3 20.2 5.5e-154 513.1 20.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 EMD69278.1 - 0.032 13.3 15.1 0.068 12.2 1.2 3.1 1 1 2 3 3 3 0 Glycosyl Hydrolase Family 88 Synaptobrevin PF00957.21 EMD69279.1 - 1.7e-32 111.1 0.6 1.9e-32 110.9 0.6 1.0 1 0 0 1 1 1 1 Synaptobrevin Chi-conotoxin PF16981.5 EMD69279.1 - 1.1 9.6 3.9 0.88 9.9 1.5 2.0 2 1 1 3 3 3 0 chi-Conotoxin or t superfamily SNARE PF05739.19 EMD69279.1 - 3.3 7.8 7.1 0.77 9.8 3.4 1.9 2 0 0 2 2 2 0 SNARE domain NAT PF04768.13 EMD69280.1 - 9e-39 132.8 0.2 1.8e-38 131.9 0.2 1.5 1 0 0 1 1 1 1 NAT, N-acetyltransferase, of N-acetylglutamate synthase Semialdhyde_dh PF01118.24 EMD69280.1 - 3.1e-32 111.5 0.0 7.9e-32 110.2 0.0 1.7 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain AA_kinase PF00696.28 EMD69280.1 - 2.6e-31 109.1 0.0 5.3e-31 108.1 0.0 1.5 1 0 0 1 1 1 1 Amino acid kinase family DapB_N PF01113.20 EMD69280.1 - 0.0017 18.5 0.0 0.0049 17.0 0.0 1.8 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus GFO_IDH_MocA PF01408.22 EMD69280.1 - 0.0029 18.4 0.0 0.02 15.7 0.0 2.2 2 0 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold IRF PF00605.17 EMD69280.1 - 0.19 12.0 0.7 0.39 11.0 0.7 1.5 1 0 0 1 1 1 0 Interferon regulatory factor transcription factor Syntaphilin PF15290.6 EMD69281.1 - 0.39 10.3 3.4 0.5 10.0 3.4 1.1 1 0 0 1 1 1 0 Golgi-localised syntaxin-1-binding clamp Glu-tRNAGln PF02686.15 EMD69282.1 - 8.8e-10 38.7 0.8 6.5e-09 36.0 0.8 2.2 1 1 0 1 1 1 1 Glu-tRNAGln amidotransferase C subunit Caps_synth_GfcC PF06251.11 EMD69282.1 - 0.084 12.5 0.4 0.11 12.0 0.4 1.3 1 1 0 1 1 1 0 Capsule biosynthesis GfcC SNAP PF14938.6 EMD69283.1 - 5.2e-113 377.2 16.7 5.8e-113 377.0 16.7 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP Hep_59 PF07052.11 EMD69283.1 - 0.056 14.2 0.3 0.13 13.0 0.3 1.7 1 0 0 1 1 1 0 Hepatocellular carcinoma-associated antigen 59 TPR_2 PF07719.17 EMD69283.1 - 0.1 12.7 19.7 2.5 8.4 0.1 6.1 5 2 2 7 7 7 0 Tetratricopeptide repeat SMBP PF16785.5 EMD69283.1 - 0.16 12.2 4.1 0.56 10.5 3.6 2.1 1 1 1 2 2 2 0 Small metal-binding protein TPR_8 PF13181.6 EMD69283.1 - 0.86 10.0 19.5 2.4 8.6 0.3 5.7 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_1 PF00515.28 EMD69283.1 - 1.3 9.0 20.2 4.7 7.2 0.6 6.0 4 2 1 5 5 5 0 Tetratricopeptide repeat TPR_3 PF07720.12 EMD69283.1 - 1.8 8.6 8.4 3.5 7.7 0.5 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat Fasciclin PF02469.22 EMD69284.1 - 9.7e-44 148.7 0.0 5e-23 81.7 0.0 2.2 2 0 0 2 2 2 2 Fasciclin domain DUF211 PF02680.14 EMD69284.1 - 0.042 14.0 0.0 8.1 6.7 0.0 2.5 2 0 0 2 2 2 0 Uncharacterized ArCR, COG1888 Pyridoxal_deC PF00282.19 EMD69285.1 - 2.3e-62 210.9 0.0 3e-62 210.5 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.19 EMD69285.1 - 5.4e-05 22.3 0.0 9.1e-05 21.6 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class-V FAD_binding_7 PF03441.14 EMD69286.1 - 8.8e-49 165.7 0.4 1.4e-48 165.1 0.4 1.2 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.18 EMD69286.1 - 8.2e-09 35.7 0.0 2.8e-08 33.9 0.0 1.8 1 1 0 1 1 1 1 DNA photolyase PGA2 PF07543.12 EMD69289.1 - 3e-16 59.6 0.0 3.4e-16 59.5 0.0 1.1 1 0 0 1 1 1 1 Protein trafficking PGA2 ELF PF03317.13 EMD69289.1 - 0.078 13.0 0.0 0.086 12.8 0.0 1.1 1 0 0 1 1 1 0 ELF protein GBP PF02263.19 EMD69289.1 - 0.13 11.5 0.0 0.15 11.3 0.0 1.1 1 0 0 1 1 1 0 Guanylate-binding protein, N-terminal domain CENP-S PF15630.6 EMD69290.1 - 2.5e-33 114.3 0.0 3.3e-33 113.9 0.0 1.1 1 0 0 1 1 1 1 CENP-S protein CENP-T_C PF15511.6 EMD69290.1 - 2.4e-09 37.2 0.0 3.2e-09 36.9 0.0 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CBFD_NFYB_HMF PF00808.23 EMD69290.1 - 0.024 14.9 0.0 0.041 14.2 0.0 1.4 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Bromo_TP PF07524.13 EMD69290.1 - 0.052 13.6 0.0 0.097 12.7 0.0 1.4 1 0 0 1 1 1 0 Bromodomain associated Histone PF00125.24 EMD69290.1 - 0.11 12.9 0.0 0.24 11.8 0.0 1.6 1 0 0 1 1 1 0 Core histone H2A/H2B/H3/H4 TFIID-31kDa PF02291.15 EMD69290.1 - 0.13 12.4 0.0 0.17 11.9 0.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit Mst1_SARAH PF11629.8 EMD69290.1 - 0.42 10.7 2.4 0.59 10.3 1.6 1.6 2 0 0 2 2 2 0 C terminal SARAH domain of Mst1 HTH_23 PF13384.6 EMD69291.1 - 0.00019 21.1 0.1 0.00089 19.0 0.1 1.9 2 0 0 2 2 2 1 Homeodomain-like domain Sigma70_r4_2 PF08281.12 EMD69291.1 - 0.00019 21.0 0.2 0.00046 19.8 0.0 1.7 2 0 0 2 2 2 1 Sigma-70, region 4 HTH_29 PF13551.6 EMD69291.1 - 0.0062 16.5 0.1 1.1 9.3 0.0 2.1 2 0 0 2 2 2 1 Winged helix-turn helix HTH_32 PF13565.6 EMD69291.1 - 0.0063 17.1 0.1 0.47 11.1 0.0 2.0 1 1 1 2 2 2 1 Homeodomain-like domain HTH_Crp_2 PF13545.6 EMD69291.1 - 0.011 15.7 0.0 0.74 9.8 0.0 2.1 2 0 0 2 2 2 0 Crp-like helix-turn-helix domain GerE PF00196.19 EMD69291.1 - 0.016 14.7 0.0 0.029 13.9 0.0 1.4 2 0 0 2 2 2 0 Bacterial regulatory proteins, luxR family HTH_38 PF13936.6 EMD69291.1 - 0.04 13.7 0.0 0.12 12.2 0.0 1.8 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_28 PF13518.6 EMD69291.1 - 0.051 13.7 0.1 0.051 13.7 0.1 1.8 3 0 0 3 3 3 0 Helix-turn-helix domain HTH_11 PF08279.12 EMD69291.1 - 0.069 13.1 0.0 0.21 11.5 0.0 1.8 2 0 0 2 2 2 0 HTH domain HTH_17 PF12728.7 EMD69291.1 - 0.082 13.1 0.0 0.11 12.7 0.0 1.2 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_10 PF04967.12 EMD69291.1 - 0.11 12.3 0.0 0.18 11.6 0.0 1.3 1 0 0 1 1 1 0 HTH DNA binding domain SesA PF17107.5 EMD69292.1 - 6.9e-24 84.4 0.1 1.1e-23 83.7 0.1 1.3 1 0 0 1 1 1 1 N-terminal domain on NACHT_NTPase and P-loop NTPases Helo_like_N PF17111.5 EMD69292.1 - 0.0017 17.8 0.5 0.0036 16.7 0.0 1.7 2 0 0 2 2 2 1 Fungal N-terminal domain of STAND proteins Erythro-docking PF09277.11 EMD69292.1 - 0.008 16.1 0.1 0.024 14.5 0.1 1.7 1 0 0 1 1 1 1 Erythronolide synthase, docking TPR_12 PF13424.6 EMD69293.1 - 2.7e-181 588.3 123.6 1.8e-18 66.6 0.8 12.8 3 2 15 18 18 17 17 Tetratricopeptide repeat TPR_10 PF13374.6 EMD69293.1 - 5.7e-174 560.1 73.7 1.8e-13 49.9 0.5 17.4 17 0 0 17 17 17 16 Tetratricopeptide repeat TPR_7 PF13176.6 EMD69293.1 - 3.4e-32 108.1 35.9 0.012 15.6 0.1 15.6 15 0 0 15 15 15 8 Tetratricopeptide repeat TPR_4 PF07721.14 EMD69293.1 - 1.9e-31 105.4 12.9 0.96 10.3 0.0 14.5 14 0 0 14 14 13 6 Tetratricopeptide repeat TPR_1 PF00515.28 EMD69293.1 - 2.7e-26 90.3 44.6 0.19 11.6 0.0 15.5 16 0 0 16 16 16 9 Tetratricopeptide repeat TPR_8 PF13181.6 EMD69293.1 - 4.3e-24 82.7 35.7 0.43 10.9 0.0 15.3 16 0 0 16 16 15 6 Tetratricopeptide repeat TPR_MalT PF17874.1 EMD69293.1 - 2.5e-23 83.0 63.2 8.6e-08 31.9 13.7 6.4 1 1 4 6 6 6 6 MalT-like TPR region TPR_16 PF13432.6 EMD69293.1 - 6.4e-21 74.7 33.0 0.044 14.4 0.1 12.2 11 3 0 11 11 11 6 Tetratricopeptide repeat TPR_17 PF13431.6 EMD69293.1 - 1.2e-20 72.3 16.8 1.6 9.3 0.0 13.7 14 0 0 14 14 14 5 Tetratricopeptide repeat TPR_2 PF07719.17 EMD69293.1 - 1.9e-14 52.5 50.6 0.39 11.0 0.3 15.8 16 0 0 16 16 16 6 Tetratricopeptide repeat TPR_19 PF14559.6 EMD69293.1 - 8.5e-10 39.0 24.8 0.15 12.6 0.1 11.3 6 2 10 16 16 14 6 Tetratricopeptide repeat YaiA PF16362.5 EMD69293.1 - 4.2e-09 36.4 18.5 3.3 7.9 0.0 10.1 6 5 5 11 11 11 2 YaiA protein ANAPC3 PF12895.7 EMD69293.1 - 4.6e-09 36.4 37.3 6 7.2 2.3 11.5 2 2 9 11 11 11 3 Anaphase-promoting complex, cyclosome, subunit 3 NACHT PF05729.12 EMD69293.1 - 2.8e-06 27.3 0.0 7.5e-06 25.9 0.0 1.8 1 0 0 1 1 1 1 NACHT domain DUF627 PF04781.12 EMD69293.1 - 4.7e-06 26.6 27.6 10 6.2 0.1 10.2 8 3 3 11 11 11 0 Protein of unknown function (DUF627) NB-ARC PF00931.22 EMD69293.1 - 5.4e-05 22.5 0.0 0.00014 21.2 0.0 1.6 1 0 0 1 1 1 1 NB-ARC domain TPR_14 PF13428.6 EMD69293.1 - 0.0029 18.3 49.2 6.5 7.8 0.0 15.0 16 1 1 17 17 15 2 Tetratricopeptide repeat Extensin-like_C PF06904.12 EMD69293.1 - 0.015 15.4 8.6 0.98 9.4 1.2 2.5 2 0 0 2 2 2 0 Extensin-like protein C-terminus AAA_16 PF13191.6 EMD69293.1 - 0.015 15.6 1.3 0.069 13.5 0.2 2.8 2 1 0 2 2 2 0 AAA ATPase domain Glyco_hydro_61 PF03443.14 EMD69294.1 - 6.7e-49 166.6 2.0 8.2e-49 166.3 0.0 1.9 2 0 0 2 2 2 1 Glycosyl hydrolase family 61 CBM_1 PF00734.18 EMD69294.1 - 4.7e-12 45.7 4.7 4.7e-12 45.7 4.7 2.2 2 0 0 2 2 2 1 Fungal cellulose binding domain RabGAP-TBC PF00566.18 EMD69295.1 - 4.2e-49 167.1 3.4 4.8e-49 166.9 0.0 2.7 4 0 0 4 4 4 1 Rab-GTPase-TBC domain Cnn_1N PF07989.11 EMD69295.1 - 0.013 15.7 16.2 0.041 14.0 6.6 3.1 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 SPAM PF02090.15 EMD69295.1 - 0.024 14.4 10.0 0.026 14.4 8.7 1.7 1 1 0 1 1 1 0 Salmonella surface presentation of antigen gene type M protein DUF4472 PF14739.6 EMD69295.1 - 0.051 14.3 19.7 0.14 12.9 11.4 2.9 1 1 0 2 2 2 0 Domain of unknown function (DUF4472) DUF2218 PF09981.9 EMD69295.1 - 0.093 13.1 0.6 0.31 11.5 0.6 1.9 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2218) Trimer_CC PF08954.11 EMD69295.1 - 1.8 8.2 8.2 0.24 11.0 2.2 2.8 3 0 0 3 3 3 0 Trimerisation motif YabA PF06156.13 EMD69295.1 - 2.6 8.7 20.6 8.1 7.1 4.5 3.0 1 1 1 2 2 2 0 Initiation control protein YabA TMEM171 PF15471.6 EMD69295.1 - 2.7 6.9 5.6 5.9 5.8 5.6 1.5 1 0 0 1 1 1 0 Transmembrane protein family 171 PspB PF06667.12 EMD69295.1 - 2.9 8.0 5.9 3.3 7.8 1.0 2.6 1 1 1 2 2 2 0 Phage shock protein B Fez1 PF06818.15 EMD69295.1 - 3.1 8.2 24.7 0.86 10.0 21.1 1.9 2 0 0 2 2 2 0 Fez1 HALZ PF02183.18 EMD69295.1 - 3.6 7.9 10.6 0.061 13.6 1.7 2.6 4 0 0 4 4 4 0 Homeobox associated leucine zipper Noelin-1 PF12308.8 EMD69295.1 - 5.2 7.1 9.4 0.73 9.9 3.1 2.4 1 1 1 2 2 2 0 Neurogenesis glycoprotein DivIC PF04977.15 EMD69295.1 - 6.3 6.6 18.2 0.57 10.0 5.4 3.6 1 1 2 3 3 3 0 Septum formation initiator KH_1 PF00013.29 EMD69296.1 - 1.4e-48 162.5 13.5 3.3e-16 58.9 0.3 3.2 3 0 0 3 3 3 3 KH domain KH_2 PF07650.17 EMD69296.1 - 1e-12 47.7 5.5 0.00042 20.1 0.1 3.3 3 0 0 3 3 3 3 KH domain KH_4 PF13083.6 EMD69296.1 - 1.2e-10 41.1 1.9 0.0013 18.6 0.1 3.3 3 0 0 3 3 3 3 KH domain MOEP19 PF16005.5 EMD69296.1 - 1.8e-06 27.9 0.0 0.0024 17.8 0.0 3.3 3 1 0 3 3 3 1 KH-like RNA-binding domain KH_5 PF13184.6 EMD69296.1 - 0.0016 18.5 5.0 0.65 10.1 0.2 3.5 3 0 0 3 3 3 1 NusA-like KH domain Ald_Xan_dh_C2 PF02738.18 EMD69297.1 - 1.1e-204 681.0 1.9 1.6e-204 680.5 1.9 1.2 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase FAD_binding_5 PF00941.21 EMD69297.1 - 2.3e-47 160.9 0.0 5.1e-47 159.8 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain in molybdopterin dehydrogenase Ald_Xan_dh_C PF01315.22 EMD69297.1 - 5.9e-35 119.9 0.0 1.6e-34 118.6 0.0 1.8 1 0 0 1 1 1 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain CO_deh_flav_C PF03450.17 EMD69297.1 - 1.2e-34 118.6 0.3 4.1e-34 116.9 0.0 2.1 2 0 0 2 2 2 1 CO dehydrogenase flavoprotein C-terminal domain Fer2_2 PF01799.20 EMD69297.1 - 1e-28 99.1 0.0 2.3e-28 98.0 0.0 1.7 1 0 0 1 1 1 1 [2Fe-2S] binding domain Fer2 PF00111.27 EMD69297.1 - 6.5e-08 32.4 0.1 6.5e-08 32.4 0.1 2.7 3 1 1 4 4 4 1 2Fe-2S iron-sulfur cluster binding domain DUF218 PF02698.17 EMD69297.1 - 0.03 14.3 0.0 0.07 13.2 0.0 1.5 1 0 0 1 1 1 0 DUF218 domain UvdE PF03851.14 EMD69298.1 - 4.1e-113 377.2 0.0 5.3e-113 376.8 0.0 1.1 1 0 0 1 1 1 1 UV-endonuclease UvdE Fungal_trans_2 PF11951.8 EMD69299.1 - 9.8e-52 176.0 0.1 1.4e-51 175.5 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD69299.1 - 1.4e-07 31.5 7.6 2.7e-07 30.6 7.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain HMGL-like PF00682.19 EMD69300.1 - 9.2e-43 146.7 0.0 3.6e-33 115.2 0.1 2.0 2 0 0 2 2 2 2 HMGL-like MARVEL PF01284.23 EMD69302.1 - 0.0078 16.2 13.5 0.011 15.7 13.5 1.3 1 0 0 1 1 1 1 Membrane-associating domain 7TM_GPCR_Srz PF10325.9 EMD69302.1 - 0.07 12.5 2.1 1.4 8.2 1.4 2.0 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srz SUR7 PF06687.12 EMD69302.1 - 3.4 7.2 17.2 0.72 9.4 0.5 2.4 1 1 1 2 2 2 0 SUR7/PalI family Nfu_N PF08712.11 EMD69303.1 - 2.8e-29 101.0 0.1 1.7e-28 98.5 0.0 2.1 2 0 0 2 2 2 1 Scaffold protein Nfu/NifU N terminal NifU PF01106.17 EMD69303.1 - 2.6e-27 94.8 0.1 4.3e-27 94.0 0.1 1.4 1 0 0 1 1 1 1 NifU-like domain DUF848 PF05852.11 EMD69304.1 - 0.00044 20.4 0.3 0.0008 19.5 0.3 1.3 1 0 0 1 1 1 1 Gammaherpesvirus protein of unknown function (DUF848) NPV_P10 PF05531.12 EMD69304.1 - 0.046 14.2 0.1 0.15 12.6 0.1 1.9 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein DASH_Spc19 PF08287.11 EMD69304.1 - 0.32 10.9 2.3 0.38 10.6 1.0 1.8 1 1 1 2 2 2 0 Spc19 ApoLp-III PF07464.11 EMD69304.1 - 0.34 11.0 3.4 0.47 10.5 0.2 2.1 2 0 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) Med28 PF11594.8 EMD69304.1 - 0.55 10.3 3.0 1.8 8.6 0.3 2.2 2 0 0 2 2 2 0 Mediator complex subunit 28 Chorismate_bind PF00425.18 EMD69305.1 - 5.9e-91 304.6 0.0 2.9e-90 302.3 0.0 1.9 2 0 0 2 2 2 1 chorismate binding enzyme Anth_synt_I_N PF04715.13 EMD69305.1 - 8.6e-29 100.6 0.0 3.7e-24 85.6 0.0 3.6 3 0 0 3 3 3 2 Anthranilate synthase component I, N terminal region CFEM PF05730.11 EMD69306.1 - 7.9e-11 41.9 9.8 2.1e-10 40.5 9.8 1.7 1 0 0 1 1 1 1 CFEM domain ISG65-75 PF11727.8 EMD69306.1 - 0.12 11.6 8.3 0.18 11.0 8.3 1.4 1 0 0 1 1 1 0 Invariant surface glycoprotein GFO_IDH_MocA PF01408.22 EMD69307.1 - 1.5e-27 96.8 0.2 2.6e-27 96.0 0.2 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 EMD69307.1 - 0.0036 17.3 0.0 0.0078 16.2 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain NAD_binding_7 PF13241.6 EMD69307.1 - 0.0054 17.1 0.0 0.0097 16.3 0.0 1.4 1 0 0 1 1 1 1 Putative NAD(P)-binding NAD_binding_3 PF03447.16 EMD69307.1 - 0.03 15.0 0.0 0.059 14.0 0.0 1.5 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain TrkA_N PF02254.18 EMD69307.1 - 0.062 13.6 0.2 0.17 12.1 0.0 1.8 2 0 0 2 2 2 0 TrkA-N domain ADH_N PF08240.12 EMD69309.1 - 2.3e-26 91.8 1.9 2.5e-26 91.7 0.5 1.8 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EMD69309.1 - 9.3e-17 61.2 0.6 3.2e-16 59.5 0.7 1.9 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EMD69309.1 - 7.7e-10 38.6 1.1 1.2e-05 24.9 0.0 2.4 1 1 0 2 2 2 2 Glucose dehydrogenase C-terminus AlaDh_PNT_C PF01262.21 EMD69309.1 - 0.011 15.0 2.5 0.02 14.2 2.5 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain ThiF PF00899.21 EMD69309.1 - 0.02 14.2 0.5 0.04 13.3 0.5 1.4 1 0 0 1 1 1 0 ThiF family ADH_zinc_N_2 PF13602.6 EMD69309.1 - 0.025 15.6 0.0 0.11 13.5 0.0 2.1 2 1 0 2 2 2 0 Zinc-binding dehydrogenase UDPG_MGDP_dh_N PF03721.14 EMD69309.1 - 0.28 10.7 1.8 0.33 10.5 0.6 1.7 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Shikimate_DH PF01488.20 EMD69309.1 - 0.29 11.2 1.2 1.5 8.9 0.3 2.4 1 1 2 3 3 3 0 Shikimate / quinate 5-dehydrogenase adh_short_C2 PF13561.6 EMD69310.1 - 8.1e-55 185.9 0.5 1e-54 185.6 0.5 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EMD69310.1 - 5.9e-52 176.0 0.5 8e-52 175.5 0.2 1.4 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.10 EMD69310.1 - 4.3e-12 46.3 1.5 7.8e-12 45.5 0.5 1.8 2 0 0 2 2 2 1 KR domain Epimerase PF01370.21 EMD69310.1 - 7.8e-05 22.2 0.1 0.00013 21.6 0.1 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Glyco_transf_5 PF08323.11 EMD69310.1 - 0.0024 17.6 0.0 0.072 12.8 0.0 2.6 2 1 1 3 3 3 1 Starch synthase catalytic domain THF_DHG_CYH_C PF02882.19 EMD69310.1 - 0.015 14.6 0.1 0.083 12.2 0.0 2.0 2 0 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain RmlD_sub_bind PF04321.17 EMD69310.1 - 0.034 13.3 0.2 0.91 8.6 0.1 2.1 2 0 0 2 2 2 0 RmlD substrate binding domain NmrA PF05368.13 EMD69310.1 - 0.058 12.9 0.2 0.12 11.9 0.2 1.5 1 0 0 1 1 1 0 NmrA-like family Glyco_transf_4 PF13439.6 EMD69310.1 - 0.098 12.7 0.0 3.4 7.6 0.0 2.4 3 0 0 3 3 3 0 Glycosyltransferase Family 4 GDP_Man_Dehyd PF16363.5 EMD69310.1 - 0.11 11.9 0.0 0.19 11.1 0.0 1.4 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase AAA_31 PF13614.6 EMD69310.1 - 0.11 12.3 0.4 2.3 8.1 0.0 2.2 2 0 0 2 2 2 0 AAA domain F420_oxidored PF03807.17 EMD69310.1 - 0.16 12.6 0.8 3.2 8.4 0.1 2.5 2 1 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent Aldo_ket_red PF00248.21 EMD69311.1 - 3.2e-43 148.0 0.0 1.3e-35 123.1 0.0 2.0 2 0 0 2 2 2 2 Aldo/keto reductase family MIOX PF05153.15 EMD69312.1 - 2.7e-123 410.4 5.1 4e-123 409.8 5.1 1.3 1 0 0 1 1 1 1 Myo-inositol oxygenase Cytochrom_C_2 PF01322.20 EMD69312.1 - 0.016 16.1 1.9 0.032 15.1 1.9 1.6 1 0 0 1 1 1 0 Cytochrome C' HD PF01966.22 EMD69312.1 - 0.14 12.4 0.1 0.72 10.1 0.0 2.2 3 0 0 3 3 3 0 HD domain Cas9_PI PF16595.5 EMD69312.1 - 0.36 10.7 7.1 2.4 8.0 2.8 2.1 2 0 0 2 2 2 0 PAM-interacting domain of CRISPR-associated endonuclease Cas9 tRNA-synt_1 PF00133.22 EMD69313.1 - 2.9e-31 108.4 0.0 4.1e-23 81.5 0.0 3.3 2 1 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 EMD69313.1 - 1.9e-13 49.9 0.0 7.1e-08 31.6 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class I (M) Anticodon_1 PF08264.13 EMD69313.1 - 6.4e-13 48.9 0.8 2e-12 47.3 0.8 1.9 1 1 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.19 EMD69313.1 - 1.4e-08 34.4 0.0 3.6e-08 33.1 0.0 1.6 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain ATP-synt_ab PF00006.25 EMD69315.1 - 9.2e-67 224.8 0.0 1.3e-66 224.4 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 EMD69315.1 - 5.9e-14 52.3 0.6 1.2e-13 51.4 0.6 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain LIM_bind PF01803.16 EMD69316.1 - 7.9e-62 208.9 0.2 7.9e-62 208.9 0.2 5.1 3 1 0 3 3 3 1 LIM-domain binding protein LAM_C PF12544.8 EMD69317.1 - 6.3e-05 23.2 0.1 0.00017 21.8 0.1 1.7 1 0 0 1 1 1 1 Lysine-2,3-aminomutase Fer4_14 PF13394.6 EMD69317.1 - 0.0016 18.5 0.0 0.0035 17.5 0.0 1.6 1 0 0 1 1 1 1 4Fe-4S single cluster domain Radical_SAM PF04055.21 EMD69317.1 - 0.0085 16.5 0.1 0.023 15.1 0.0 1.9 2 1 0 2 2 2 1 Radical SAM superfamily Fer4_12 PF13353.6 EMD69317.1 - 0.014 15.6 0.0 0.14 12.5 0.0 2.2 2 0 0 2 2 2 0 4Fe-4S single cluster domain GET2 PF08690.10 EMD69319.1 - 4.8e-26 92.2 2.0 7.1e-24 85.0 2.0 2.1 1 1 0 1 1 1 1 GET complex subunit GET2 PTH2 PF01981.16 EMD69320.1 - 5.1e-48 162.2 0.1 7e-48 161.8 0.1 1.2 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 Treacle PF03546.14 EMD69320.1 - 0.019 13.8 0.4 0.026 13.4 0.4 1.2 1 0 0 1 1 1 0 Treacher Collins syndrome protein Treacle S-antigen PF05756.11 EMD69320.1 - 0.11 12.9 0.2 0.17 12.3 0.2 1.2 1 0 0 1 1 1 0 S-antigen protein Ribosomal_L28 PF00830.19 EMD69321.1 - 9.2e-16 57.8 2.0 1.1e-15 57.6 0.9 1.7 2 0 0 2 2 2 1 Ribosomal L28 family YodL PF14191.6 EMD69321.1 - 0.14 13.0 0.1 0.4 11.5 0.1 1.7 1 0 0 1 1 1 0 YodL-like F-box-like_2 PF13013.6 EMD69322.1 - 0.015 15.2 0.0 0.038 13.9 0.0 1.7 1 0 0 1 1 1 0 F-box-like domain TPR_12 PF13424.6 EMD69322.1 - 0.02 15.2 0.4 0.061 13.6 0.0 2.1 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 EMD69322.1 - 0.068 13.3 0.0 0.32 11.2 0.0 2.2 1 0 0 1 1 1 0 Tetratricopeptide repeat PMI_typeI PF01238.21 EMD69323.1 - 8.5e-77 258.9 0.0 5.7e-76 256.1 0.0 1.8 1 1 0 1 1 1 1 Phosphomannose isomerase type I Cupin_2 PF07883.11 EMD69323.1 - 5.5e-07 29.2 0.0 0.0035 17.0 0.0 2.5 2 0 0 2 2 2 2 Cupin domain AraC_binding PF02311.19 EMD69323.1 - 0.0008 19.3 0.0 0.01 15.7 0.0 2.2 2 0 0 2 2 2 1 AraC-like ligand binding domain Glyco_transf_34 PF05637.12 EMD69324.1 - 1.2e-64 218.3 0.0 1.5e-64 218.0 0.0 1.1 1 0 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family Phage_BR0599 PF09356.10 EMD69324.1 - 0.12 12.7 0.0 0.23 11.8 0.0 1.4 1 0 0 1 1 1 0 Phage conserved hypothetical protein BR0599 MMR_HSR1 PF01926.23 EMD69325.1 - 0.00013 22.0 0.0 0.65 10.1 0.0 2.9 3 0 0 3 3 3 2 50S ribosome-binding GTPase Zn-ribbon_8 PF09723.10 EMD69325.1 - 0.95 9.6 3.1 19 5.5 0.4 2.5 2 0 0 2 2 2 0 Zinc ribbon domain Aminotran_1_2 PF00155.21 EMD69326.1 - 2.2e-88 296.9 0.0 2.5e-88 296.7 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Hpt PF01627.23 EMD69327.1 - 6.8e-10 39.1 0.0 1.1e-09 38.4 0.0 1.4 1 0 0 1 1 1 1 Hpt domain DUF4844 PF16133.5 EMD69327.1 - 0.012 16.1 1.3 0.036 14.6 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4844) NuA4 PF09340.10 EMD69327.1 - 0.024 14.5 3.6 0.029 14.2 1.4 2.1 2 1 0 2 2 2 0 Histone acetyltransferase subunit NuA4 DUF356 PF04009.12 EMD69327.1 - 0.075 13.3 0.1 0.14 12.4 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF356) DUF4241 PF14025.6 EMD69327.1 - 4.3 7.6 6.3 10 6.3 0.8 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4241) AKAP7_NLS PF10469.9 EMD69328.1 - 9.5e-24 84.4 0.0 9.7e-21 74.6 0.0 2.0 2 0 0 2 2 2 2 AKAP7 2'5' RNA ligase-like domain Ferritin PF00210.24 EMD69329.1 - 0.079 12.9 1.0 0.2 11.6 0.5 2.0 2 0 0 2 2 2 0 Ferritin-like domain DBINO PF13892.6 EMD69329.1 - 4.9 7.5 6.8 2.4 8.5 4.3 1.7 2 0 0 2 2 2 0 DNA-binding domain Cutinase PF01083.22 EMD69331.1 - 1.2e-50 172.0 8.5 1.4e-50 171.8 8.5 1.0 1 0 0 1 1 1 1 Cutinase PE-PPE PF08237.11 EMD69331.1 - 6.8e-06 25.8 0.1 8.7e-06 25.4 0.1 1.1 1 0 0 1 1 1 1 PE-PPE domain VirJ PF06057.11 EMD69331.1 - 0.013 15.4 0.0 0.018 14.9 0.0 1.2 1 0 0 1 1 1 0 Bacterial virulence protein (VirJ) Abhydrolase_1 PF00561.20 EMD69331.1 - 0.028 14.0 0.0 0.076 12.6 0.0 1.6 1 1 1 2 2 2 0 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EMD69331.1 - 0.066 13.8 0.2 0.07 13.7 0.2 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EMD69331.1 - 0.084 12.1 0.2 0.1 11.8 0.2 1.1 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Herpes_capsid PF06112.11 EMD69331.1 - 0.67 10.0 4.9 1 9.4 4.9 1.3 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein Lipase_2 PF01674.18 EMD69331.1 - 1 8.8 5.4 3.5 7.1 5.4 1.7 1 1 0 1 1 1 0 Lipase (class 2) DAO PF01266.24 EMD69332.1 - 2.9e-32 112.6 0.9 8.9e-32 111.0 0.9 1.7 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EMD69332.1 - 2.9e-07 30.6 0.1 0.011 15.7 0.1 2.4 2 0 0 2 2 2 2 FAD-NAD(P)-binding Trp_halogenase PF04820.14 EMD69332.1 - 0.00045 19.2 0.1 0.0051 15.7 0.1 2.0 2 0 0 2 2 2 1 Tryptophan halogenase NAD_binding_8 PF13450.6 EMD69332.1 - 0.00061 20.0 0.1 0.0043 17.2 0.0 2.6 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EMD69332.1 - 0.00076 18.8 0.0 0.25 10.5 0.1 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EMD69332.1 - 0.0011 18.1 0.5 0.0026 16.9 0.1 1.7 2 0 0 2 2 2 1 Glucose inhibited division protein A Lycopene_cycl PF05834.12 EMD69332.1 - 0.0076 15.3 0.1 0.65 9.0 0.1 2.2 2 0 0 2 2 2 1 Lycopene cyclase protein Pyr_redox_3 PF13738.6 EMD69332.1 - 0.019 14.2 0.2 3.8 6.7 0.1 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Sacchrp_dh_NADP PF03435.18 EMD69332.1 - 0.037 14.3 0.0 2.9 8.2 0.0 2.4 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain Amino_oxidase PF01593.24 EMD69332.1 - 0.038 13.3 0.0 0.056 12.7 0.0 1.3 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase Thi4 PF01946.17 EMD69332.1 - 0.05 12.8 0.0 0.18 11.0 0.0 1.9 2 0 0 2 2 2 0 Thi4 family TrkA_N PF02254.18 EMD69332.1 - 0.097 12.9 0.0 0.19 12.0 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain Glyco_hydro_3_C PF01915.22 EMD69333.1 - 2.8e-53 180.9 0.2 5e-53 180.1 0.2 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 EMD69333.1 - 1.3e-49 169.3 0.0 1.8e-49 168.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 EMD69333.1 - 8.4e-22 77.1 2.2 8.4e-22 77.1 2.2 2.4 2 0 0 2 2 2 1 Fibronectin type III-like domain DUF11 PF01345.18 EMD69333.1 - 0.0027 18.0 3.0 0.011 16.0 3.0 2.0 1 1 0 1 1 1 1 Domain of unknown function DUF11 Sugar-bind PF04198.13 EMD69333.1 - 0.025 13.7 0.1 0.054 12.6 0.1 1.4 1 0 0 1 1 1 0 Putative sugar-binding domain ChiW_Ig_like PF18683.1 EMD69333.1 - 0.76 10.0 6.1 7.4 6.9 1.7 3.4 3 0 0 3 3 3 0 Chitinase W immunoglobulin-like domain His_Phos_1 PF00300.22 EMD69335.1 - 1.3e-26 93.5 0.0 2.8e-26 92.4 0.0 1.5 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) MFS_1 PF07690.16 EMD69337.1 - 7.4e-24 84.3 16.7 9.2e-24 84.0 16.7 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily CBFB_NFYA PF02045.15 EMD69337.1 - 0.14 12.8 0.1 0.32 11.7 0.1 1.6 1 0 0 1 1 1 0 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B DUF1304 PF06993.12 EMD69337.1 - 5 7.2 6.1 1.6 8.8 0.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1304) TauD PF02668.16 EMD69338.1 - 4.8e-58 197.1 0.9 5.9e-58 196.8 0.9 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF913 PF06025.12 EMD69339.1 - 6.5e-128 426.8 0.0 6.5e-128 426.8 0.0 7.9 8 1 0 8 8 8 2 Domain of Unknown Function (DUF913) DUF908 PF06012.12 EMD69339.1 - 4.9e-107 358.5 0.0 4.9e-107 358.5 0.0 5.9 6 1 0 6 6 6 1 Domain of Unknown Function (DUF908) HECT PF00632.25 EMD69339.1 - 8.2e-94 314.5 0.1 1.4e-93 313.7 0.1 1.4 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) UBM PF14377.6 EMD69339.1 - 1.4e-24 84.7 37.7 9.2e-11 40.8 0.9 4.5 4 0 0 4 4 4 3 Ubiquitin binding region UBA PF00627.31 EMD69339.1 - 0.097 12.6 0.1 0.27 11.2 0.1 1.8 1 0 0 1 1 1 0 UBA/TS-N domain GCN5L1 PF06320.13 EMD69340.1 - 8.1e-20 71.1 3.5 9.6e-20 70.8 3.5 1.1 1 0 0 1 1 1 1 GCN5-like protein 1 (GCN5L1) Cutinase PF01083.22 EMD69341.1 - 3.2e-42 144.5 0.0 4.7e-42 144.0 0.0 1.2 1 0 0 1 1 1 1 Cutinase PE-PPE PF08237.11 EMD69341.1 - 0.057 13.0 0.1 0.12 11.9 0.1 1.5 2 0 0 2 2 2 0 PE-PPE domain VirJ PF06057.11 EMD69341.1 - 0.11 12.4 0.0 0.17 11.8 0.0 1.3 1 0 0 1 1 1 0 Bacterial virulence protein (VirJ) Acetyltransf_10 PF13673.7 EMD69342.1 - 8.7e-08 32.2 0.0 1.3e-07 31.6 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EMD69342.1 - 6.6e-07 29.7 0.0 1e-06 29.1 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EMD69342.1 - 2.1e-06 27.9 0.0 3.7e-06 27.2 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Nairo_nucleo PF02477.15 EMD69343.1 - 0.17 10.7 0.1 0.22 10.3 0.1 1.1 1 0 0 1 1 1 0 Nucleocapsid N protein Collagen_mid PF15984.5 EMD69344.1 - 0.043 13.6 5.7 1.1 8.9 0.2 2.3 2 0 0 2 2 2 0 Bacterial collagen, middle region ApoLp-III PF07464.11 EMD69344.1 - 0.67 10.0 8.4 2.7 8.1 0.5 3.3 3 2 0 3 3 3 0 Apolipophorin-III precursor (apoLp-III) CCD PF07860.11 EMD69344.1 - 3.8 7.6 4.9 58 3.7 0.2 3.8 2 1 0 3 3 3 0 WisP family C-Terminal Region Tape_meas_lam_C PF09718.10 EMD69344.1 - 7.4 6.8 7.0 27 5.0 4.2 3.1 3 0 0 3 3 3 0 Lambda phage tail tape-measure protein (Tape_meas_lam_C) Vps39_2 PF10367.9 EMD69346.1 - 3.3e-32 111.2 0.0 3e-31 108.1 0.0 2.6 3 0 0 3 3 3 1 Vacuolar sorting protein 39 domain 2 Vps39_1 PF10366.9 EMD69346.1 - 3.8e-32 110.8 0.5 4.4e-31 107.4 0.0 2.8 4 0 0 4 4 2 1 Vacuolar sorting protein 39 domain 1 CNH PF00780.22 EMD69346.1 - 1.1e-18 67.8 0.0 7.4e-18 65.1 0.0 2.0 1 1 0 1 1 1 1 CNH domain Clathrin PF00637.20 EMD69346.1 - 1.3e-06 28.4 4.1 1.3e-06 28.4 4.1 2.8 3 0 0 3 3 3 1 Region in Clathrin and VPS TPR_1 PF00515.28 EMD69346.1 - 0.0035 17.1 9.6 3.4 7.7 2.3 4.6 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 EMD69346.1 - 0.0054 17.3 2.9 1.5 9.5 0.5 3.9 3 1 1 4 4 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EMD69346.1 - 0.007 16.6 4.9 0.043 14.0 0.2 3.3 3 1 0 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 EMD69346.1 - 0.0085 16.2 7.6 0.97 9.8 0.8 4.1 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 EMD69346.1 - 0.013 15.5 7.5 7.7 6.9 0.1 4.5 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_10 PF13374.6 EMD69346.1 - 0.032 14.1 1.4 19 5.3 0.1 4.1 3 1 1 4 4 4 0 Tetratricopeptide repeat ANAPC8 PF04049.13 EMD69346.1 - 0.047 13.7 0.3 0.47 10.5 0.0 2.3 2 0 0 2 2 2 0 Anaphase promoting complex subunit 8 / Cdc23 TPR_5 PF12688.7 EMD69346.1 - 0.058 13.6 0.2 0.28 11.5 0.2 2.1 2 0 0 2 2 2 0 Tetratrico peptide repeat GyrB_insert PF18053.1 EMD69346.1 - 0.098 12.5 0.4 0.2 11.5 0.4 1.5 1 0 0 1 1 1 0 DNA gyrase B subunit insert domain TPR_12 PF13424.6 EMD69346.1 - 0.14 12.5 8.6 13 6.1 0.5 4.3 3 2 1 4 4 4 0 Tetratricopeptide repeat SRP_TPR_like PF17004.5 EMD69346.1 - 0.17 11.9 3.7 1.5 8.9 0.1 2.7 2 0 0 2 2 2 0 Putative TPR-like repeat PPR PF01535.20 EMD69346.1 - 0.19 12.1 0.3 8.6 6.9 0.0 3.2 2 0 0 2 2 2 0 PPR repeat TPR_19 PF14559.6 EMD69346.1 - 0.39 11.3 10.6 0.11 13.0 0.6 4.2 4 1 0 4 4 4 0 Tetratricopeptide repeat HbrB PF08539.11 EMD69347.1 - 7.6e-51 172.5 0.0 2.2e-50 171.0 0.0 1.9 1 0 0 1 1 1 1 HbrB-like Cupin_3 PF05899.12 EMD69348.1 - 3e-05 23.6 0.1 7.3e-05 22.4 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF861) EutQ PF06249.12 EMD69348.1 - 0.00094 19.0 0.0 0.0011 18.8 0.0 1.1 1 0 0 1 1 1 1 Ethanolamine utilisation protein EutQ DUF5305 PF17231.2 EMD69348.1 - 0.13 11.7 0.0 0.15 11.5 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5305) COesterase PF00135.28 EMD69350.1 - 7.5e-74 249.4 0.3 1.1e-72 245.6 0.3 2.0 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EMD69350.1 - 7.6e-07 29.2 0.4 9.5e-06 25.6 0.3 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EMD69350.1 - 8.9e-06 25.3 0.3 1.6e-05 24.5 0.3 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family DUF1674 PF07896.12 EMD69351.1 - 6.7e-20 71.3 2.2 6.7e-20 71.3 2.2 2.3 2 1 1 3 3 3 1 Protein of unknown function (DUF1674) TIP49 PF06068.13 EMD69352.1 - 5.7e-163 542.1 0.0 6.9e-163 541.9 0.0 1.1 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 EMD69352.1 - 3.8e-21 75.0 0.1 1.2e-20 73.4 0.1 1.9 2 0 0 2 2 2 1 TIP49 AAA-lid domain AAA PF00004.29 EMD69352.1 - 1.2e-10 41.9 0.1 3e-07 30.9 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EMD69352.1 - 1.7e-09 37.6 0.1 1.2e-06 28.3 0.0 2.3 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EMD69352.1 - 2.6e-05 24.7 0.3 0.00047 20.6 0.3 2.3 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EMD69352.1 - 2.7e-05 24.5 0.2 0.19 12.0 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_28 PF13521.6 EMD69352.1 - 3.9e-05 23.9 0.6 0.0017 18.7 0.1 2.3 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 EMD69352.1 - 4.4e-05 23.9 0.7 0.044 14.1 0.2 2.3 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.14 EMD69352.1 - 0.00039 20.4 0.2 0.12 12.3 0.0 2.5 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 EMD69352.1 - 0.0016 18.2 0.1 0.53 10.0 0.0 2.4 2 0 0 2 2 2 1 Sigma-54 interaction domain Zeta_toxin PF06414.12 EMD69352.1 - 0.0055 16.0 0.4 0.013 14.8 0.3 1.6 2 0 0 2 2 2 1 Zeta toxin Mg_chelatase PF01078.21 EMD69352.1 - 0.018 14.4 0.3 0.58 9.5 0.0 2.3 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI DnaB_C PF03796.15 EMD69352.1 - 0.019 14.3 0.0 0.035 13.4 0.0 1.4 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain AAA_25 PF13481.6 EMD69352.1 - 0.022 14.3 0.0 0.04 13.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 EMD69352.1 - 0.029 14.1 0.1 0.06 13.1 0.1 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein ATPase PF06745.13 EMD69352.1 - 0.038 13.3 0.2 0.093 12.1 0.0 1.8 2 0 0 2 2 2 0 KaiC DUF2075 PF09848.9 EMD69352.1 - 0.041 13.1 0.0 0.06 12.6 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_18 PF13238.6 EMD69352.1 - 0.072 13.6 0.0 0.2 12.2 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 EMD69352.1 - 0.087 12.5 0.2 0.61 9.8 0.1 2.2 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 EMD69352.1 - 0.11 12.4 0.0 0.21 11.5 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA_7 PF12775.7 EMD69352.1 - 0.11 12.0 0.2 0.48 9.9 0.0 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region TsaE PF02367.17 EMD69352.1 - 0.12 12.3 0.1 0.25 11.3 0.1 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Bromodomain PF00439.25 EMD69353.1 - 1.7e-40 136.9 3.0 2.2e-20 72.5 0.1 2.5 2 0 0 2 2 2 2 Bromodomain BET PF17035.5 EMD69353.1 - 6.8e-19 67.8 0.3 1.4e-18 66.8 0.3 1.6 1 0 0 1 1 1 1 Bromodomain extra-terminal - transcription regulation DUF4407 PF14362.6 EMD69353.1 - 0.12 11.7 3.1 0.24 10.7 3.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Utp12 PF04003.12 EMD69354.1 - 4e-26 91.4 0.1 1.3e-25 89.8 0.1 1.8 2 0 0 2 2 2 1 Dip2/Utp12 Family zf-C2H2 PF00096.26 EMD69356.1 - 0.0028 18.0 11.3 0.018 15.4 1.3 2.9 2 1 0 2 2 2 2 Zinc finger, C2H2 type zf-C3H1 PF10650.9 EMD69356.1 - 0.14 11.9 6.1 0.37 10.6 0.5 2.4 2 0 0 2 2 2 0 Putative zinc-finger domain zf-C2H2_4 PF13894.6 EMD69356.1 - 0.18 12.8 10.7 0.34 11.9 0.8 2.8 2 1 0 2 2 2 0 C2H2-type zinc finger Clr5 PF14420.6 EMD69357.1 - 2.2e-15 56.6 0.3 2.2e-15 56.6 0.3 1.6 2 0 0 2 2 2 1 Clr5 domain Smr PF01713.21 EMD69357.1 - 0.039 14.3 0.3 0.056 13.8 0.3 1.4 1 1 0 1 1 1 0 Smr domain CFAP91 PF14738.6 EMD69357.1 - 0.4 10.7 6.7 0.48 10.5 2.0 2.0 1 1 1 2 2 2 0 Cilia- and flagella-associated protein 91 TPR_12 PF13424.6 EMD69358.1 - 4.8e-53 177.4 16.2 8e-21 74.1 0.8 2.9 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 EMD69358.1 - 1.5e-44 148.7 7.4 2.7e-12 46.1 0.1 4.0 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_1 PF00515.28 EMD69358.1 - 5.4e-17 60.8 1.2 0.00024 20.8 0.0 4.1 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_7 PF13176.6 EMD69358.1 - 1e-14 53.3 8.4 6.7e-05 22.6 0.0 4.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.6 EMD69358.1 - 6e-12 45.3 6.9 0.0039 17.9 0.1 4.0 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.6 EMD69358.1 - 5.7e-10 39.7 6.1 0.027 15.1 0.2 4.0 3 1 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 EMD69358.1 - 9.8e-09 34.7 6.0 0.32 11.2 0.1 4.2 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_4 PF07721.14 EMD69358.1 - 4.8e-08 32.9 5.1 0.4 11.4 0.0 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 EMD69358.1 - 1.8e-07 30.8 0.5 0.26 11.6 0.0 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.6 EMD69358.1 - 0.0001 22.4 0.6 7.5 7.2 0.0 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat PspB PF06667.12 EMD69358.1 - 0.00021 21.2 0.9 0.92 9.6 0.0 3.1 3 0 0 3 3 3 1 Phage shock protein B DUF1925 PF09094.11 EMD69358.1 - 0.0017 18.6 0.1 0.52 10.7 0.0 2.4 1 1 1 2 2 2 1 Domain of unknown function (DUF1925) TPR_19 PF14559.6 EMD69358.1 - 0.0017 18.8 1.6 0.032 14.7 0.1 3.0 2 1 2 4 4 4 2 Tetratricopeptide repeat Atu4866 PF11512.8 EMD69358.1 - 0.0095 16.3 0.2 7.3 7.0 0.0 2.9 3 0 0 3 3 3 1 Agrobacterium tumefaciens protein Atu4866 Phosphatase PF15698.5 EMD69358.1 - 0.011 14.8 0.4 1.6 7.8 0.0 2.7 1 1 2 3 3 3 0 Phosphatase PPR PF01535.20 EMD69358.1 - 0.014 15.6 0.5 9.3 6.8 0.0 3.2 3 0 0 3 3 3 0 PPR repeat ANAPC3 PF12895.7 EMD69358.1 - 0.021 15.0 0.3 16 5.8 0.1 3.0 1 1 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 DUF1897 PF09005.10 EMD69358.1 - 0.041 13.4 1.9 14 5.3 0.2 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF1897) TPR_6 PF13174.6 EMD69358.1 - 0.26 12.0 7.0 62 4.6 0.2 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat Esterase_phd PF10503.9 EMD69360.1 - 2.1e-22 79.7 0.6 3.1e-22 79.1 0.6 1.2 1 0 0 1 1 1 1 Esterase PHB depolymerase Peptidase_S9 PF00326.21 EMD69360.1 - 4.7e-09 36.0 0.1 7e-09 35.5 0.1 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family BAAT_C PF08840.11 EMD69360.1 - 0.0013 18.7 0.1 0.0022 18.0 0.1 1.3 1 0 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal Esterase PF00756.20 EMD69360.1 - 0.0091 15.7 0.2 0.011 15.3 0.2 1.3 1 0 0 1 1 1 1 Putative esterase Abhydrolase_3 PF07859.13 EMD69360.1 - 0.04 13.8 0.1 0.051 13.4 0.1 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_1 PF00561.20 EMD69360.1 - 0.046 13.3 0.1 0.066 12.8 0.1 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 EMD69360.1 - 0.097 12.5 0.1 0.8 9.5 0.0 2.0 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase DLH PF01738.18 EMD69360.1 - 0.12 11.9 1.6 0.61 9.6 0.3 2.1 1 1 1 2 2 2 0 Dienelactone hydrolase family Clat_adaptor_s PF01217.20 EMD69361.1 - 7.2e-42 142.7 0.1 2.3e-41 141.1 0.1 1.7 1 1 0 1 1 1 1 Clathrin adaptor complex small chain Frataxin_Cyay PF01491.16 EMD69362.1 - 5.2e-33 113.4 0.0 6.6e-33 113.0 0.0 1.1 1 0 0 1 1 1 1 Frataxin-like domain zf-CSL PF05207.13 EMD69363.1 - 1.2e-19 69.8 1.9 1.4e-19 69.5 1.9 1.1 1 0 0 1 1 1 1 CSL zinc finger zf-TFIIB PF13453.6 EMD69363.1 - 1.1 8.7 4.7 1.9 7.9 1.9 2.2 2 0 0 2 2 2 0 Transcription factor zinc-finger Sec6 PF06046.13 EMD69364.1 - 1.6e-163 545.1 2.6 1.6e-163 545.1 2.6 1.7 2 0 0 2 2 2 1 Exocyst complex component Sec6 Vps54_N PF10475.9 EMD69364.1 - 0.051 12.9 2.0 0.19 11.0 2.0 2.0 1 0 0 1 1 1 0 Vacuolar-sorting protein 54, of GARP complex AAA_13 PF13166.6 EMD69364.1 - 0.065 11.9 6.7 0.047 12.3 4.8 1.6 1 1 1 2 2 2 0 AAA domain Noelin-1 PF12308.8 EMD69364.1 - 0.089 12.8 1.5 2.3 8.3 0.5 2.9 2 0 0 2 2 2 0 Neurogenesis glycoprotein FANCI_S3 PF14677.6 EMD69364.1 - 0.1 12.3 3.0 0.33 10.6 0.1 2.8 3 0 0 3 3 3 0 FANCI solenoid 3 CREPT PF16566.5 EMD69364.1 - 0.33 11.1 4.3 0.67 10.1 0.3 3.1 3 1 0 3 3 3 0 Cell-cycle alteration and expression-elevated protein in tumour Vps53_N PF04100.12 EMD69364.1 - 2.2 7.2 12.2 0.47 9.4 1.4 3.1 2 2 0 2 2 2 0 Vps53-like, N-terminal DUF1664 PF07889.12 EMD69364.1 - 5.3 7.1 7.0 3.3 7.8 0.8 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) Retrotrans_gag PF03732.17 EMD69364.1 - 5.9 7.2 8.2 3 8.2 0.1 4.4 4 1 0 5 5 5 0 Retrotransposon gag protein Dynactin_p22 PF07426.11 EMD69364.1 - 8.4 6.2 8.9 1 9.2 0.7 3.3 3 1 1 4 4 4 0 Dynactin subunit p22 BRE1 PF08647.11 EMD69364.1 - 9.1 6.4 7.4 7.2 6.8 3.5 2.6 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase Abhydrolase_1 PF00561.20 EMD69366.1 - 3e-18 66.4 0.0 3.6e-18 66.1 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_4 PF08386.10 EMD69366.1 - 1.3e-17 63.8 0.0 3e-17 62.6 0.0 1.6 1 0 0 1 1 1 1 TAP-like protein Auxin_BP PF02041.16 EMD69366.1 - 0.089 12.4 0.0 0.18 11.4 0.0 1.5 1 0 0 1 1 1 0 Auxin binding protein TPR_10 PF13374.6 EMD69368.1 - 2.3e-147 475.6 3.7 1.6e-13 50.1 0.0 11.9 11 0 0 11 11 11 11 Tetratricopeptide repeat TPR_12 PF13424.6 EMD69368.1 - 3.6e-116 379.6 24.7 2.3e-14 53.4 0.1 10.3 1 1 10 11 11 11 11 Tetratricopeptide repeat TPR_7 PF13176.6 EMD69368.1 - 3.5e-47 155.0 4.4 0.00063 19.6 0.0 11.1 10 0 0 10 10 10 10 Tetratricopeptide repeat TPR_1 PF00515.28 EMD69368.1 - 1.9e-25 87.6 0.4 0.087 12.7 0.0 10.5 10 0 0 10 10 10 5 Tetratricopeptide repeat TPR_2 PF07719.17 EMD69368.1 - 2.5e-25 86.5 2.5 0.08 13.1 0.0 11.0 10 0 0 10 10 10 5 Tetratricopeptide repeat TPR_19 PF14559.6 EMD69368.1 - 9e-22 77.4 0.3 0.02 15.4 0.0 9.7 7 2 3 10 10 9 4 Tetratricopeptide repeat TPR_17 PF13431.6 EMD69368.1 - 1.2e-19 69.1 5.8 1.4 9.5 0.0 10.4 10 0 0 10 10 9 3 Tetratricopeptide repeat TPR_MalT PF17874.1 EMD69368.1 - 2.7e-18 66.5 17.3 3.7e-09 36.4 2.6 4.3 2 1 3 5 5 4 4 MalT-like TPR region TPR_16 PF13432.6 EMD69368.1 - 1.6e-17 63.8 0.0 0.3 11.8 0.0 9.3 8 2 1 9 9 9 3 Tetratricopeptide repeat TPR_4 PF07721.14 EMD69368.1 - 1.8e-17 62.1 0.0 2.2 9.2 0.0 9.5 9 0 0 9 9 8 3 Tetratricopeptide repeat NB-ARC PF00931.22 EMD69368.1 - 3.9e-15 55.7 0.2 2.4e-14 53.1 0.0 2.3 2 0 0 2 2 2 1 NB-ARC domain HET PF06985.11 EMD69368.1 - 5.8e-13 49.4 8.2 3.5e-10 40.4 0.9 3.5 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) TPR_8 PF13181.6 EMD69368.1 - 1.9e-11 43.2 8.1 6.7 7.2 0.0 10.4 11 0 0 11 11 11 0 Tetratricopeptide repeat PPR PF01535.20 EMD69368.1 - 9.4e-11 41.2 1.7 0.84 10.0 0.0 9.1 10 0 0 10 10 10 1 PPR repeat TPR_14 PF13428.6 EMD69368.1 - 1.1e-07 32.1 13.5 8.9 7.4 0.0 10.4 12 0 0 12 12 10 0 Tetratricopeptide repeat TPR_20 PF14561.6 EMD69368.1 - 7.4e-07 29.4 7.9 10 6.5 0.0 9.0 2 1 10 12 12 11 0 Tetratricopeptide repeat AAA_16 PF13191.6 EMD69368.1 - 1.4e-05 25.5 0.7 6.9e-05 23.3 0.1 2.6 2 1 0 2 2 1 1 AAA ATPase domain AAA_22 PF13401.6 EMD69368.1 - 0.0002 21.6 0.0 0.00086 19.6 0.0 2.2 1 0 0 1 1 1 1 AAA domain DUF3660 PF12398.8 EMD69368.1 - 0.0012 18.8 1.2 35 4.6 0.0 5.3 4 0 0 4 4 4 0 Receptor serine/threonine kinase RPN6_N PF18055.1 EMD69368.1 - 0.0014 19.0 9.7 14 6.0 0.1 6.1 1 1 6 8 8 8 0 26S proteasome regulatory subunit RPN6 N-terminal domain DUF2664 PF10867.8 EMD69368.1 - 0.006 17.0 9.9 79 3.8 0.2 8.2 11 0 0 11 11 8 0 Protein of unknown function (DUF2664) ABC_tran PF00005.27 EMD69368.1 - 0.022 15.3 0.1 9.6 6.7 0.0 2.9 2 0 0 2 2 2 0 ABC transporter CutA1 PF03091.15 EMD69368.1 - 0.03 14.2 19.4 15 5.5 0.1 7.7 1 1 5 8 8 8 0 CutA1 divalent ion tolerance protein PPR_2 PF13041.6 EMD69368.1 - 0.037 14.2 0.3 38 4.6 0.0 4.7 4 0 0 4 4 4 0 PPR repeat family AAA_5 PF07728.14 EMD69368.1 - 0.051 13.6 0.0 0.14 12.2 0.0 1.8 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 EMD69368.1 - 0.053 13.3 0.0 0.15 11.8 0.0 1.7 1 0 0 1 1 1 0 IstB-like ATP binding protein ATPase_2 PF01637.18 EMD69368.1 - 0.054 13.4 0.0 0.11 12.4 0.0 1.6 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea TPR_6 PF13174.6 EMD69368.1 - 0.075 13.7 10.9 19 6.1 0.0 7.6 9 0 0 9 9 6 0 Tetratricopeptide repeat Bac_chlorC PF02043.17 EMD69368.1 - 0.13 12.2 0.0 29 4.8 0.0 3.5 2 1 1 3 3 3 0 Bacteriochlorophyll C binding protein A2M PF00207.22 EMD69368.1 - 0.27 11.1 1.3 64 3.5 0.0 4.1 2 2 0 4 4 4 0 Alpha-2-macroglobulin family DUF1897 PF09005.10 EMD69368.1 - 1.5 8.4 4.8 31 4.2 0.0 4.5 5 0 0 5 5 5 0 Domain of unknown function (DUF1897) ADH_N PF08240.12 EMD69370.1 - 8.4e-30 102.9 0.4 1.5e-29 102.1 0.4 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EMD69370.1 - 5.2e-23 81.5 0.1 7.9e-23 80.9 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EMD69370.1 - 0.0013 19.8 0.0 0.002 19.2 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase adh_short PF00106.25 EMD69370.1 - 0.0044 16.5 1.0 0.0091 15.5 0.9 1.7 1 1 0 1 1 1 1 short chain dehydrogenase CLTH PF10607.9 EMD69371.1 - 6.3e-30 104.0 0.0 7.9e-30 103.7 0.0 1.1 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.11 EMD69371.1 - 7.3e-10 38.4 0.0 1e-08 34.8 0.0 2.4 2 0 0 2 2 2 1 LisH PRK PF00485.18 EMD69372.1 - 9e-59 198.5 0.0 1.3e-58 198.0 0.0 1.2 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family UPRTase PF14681.6 EMD69372.1 - 1.3e-39 135.9 0.0 1.9e-39 135.3 0.0 1.2 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase CPT PF07931.12 EMD69372.1 - 8.4e-06 25.7 0.0 3.1e-05 23.9 0.0 1.9 2 0 0 2 2 2 1 Chloramphenicol phosphotransferase-like protein AAA_33 PF13671.6 EMD69372.1 - 0.0016 18.6 0.0 0.031 14.4 0.0 2.6 3 0 0 3 3 3 1 AAA domain AAA_18 PF13238.6 EMD69372.1 - 0.0017 18.9 0.0 0.0032 18.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 EMD69372.1 - 0.016 14.5 0.0 0.03 13.6 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA PF00004.29 EMD69372.1 - 0.036 14.5 0.0 0.096 13.1 0.0 1.8 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) TIP49 PF06068.13 EMD69372.1 - 0.047 12.9 0.0 0.072 12.3 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_5 PF07728.14 EMD69372.1 - 0.059 13.4 0.0 1.2 9.1 0.0 2.9 3 1 0 3 3 3 0 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EMD69372.1 - 0.13 12.7 0.0 0.35 11.2 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.27 EMD69372.1 - 0.13 12.8 0.9 0.27 11.7 0.4 1.7 2 0 0 2 2 2 0 ABC transporter AAA_17 PF13207.6 EMD69372.1 - 0.2 12.1 0.1 4.9 7.6 0.3 2.7 2 1 0 2 2 2 0 AAA domain AAA_24 PF13479.6 EMD69372.1 - 0.2 11.4 0.0 0.34 10.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain Metallophos PF00149.28 EMD69373.1 - 1.8e-36 126.5 0.3 2.5e-36 126.1 0.3 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EMD69373.1 - 0.024 14.8 0.0 0.039 14.1 0.0 1.3 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain STPPase_N PF16891.5 EMD69373.1 - 0.13 12.7 0.4 0.39 11.2 0.4 1.9 1 1 0 1 1 1 0 Serine-threonine protein phosphatase N-terminal domain Pmp3 PF01679.17 EMD69375.1 - 1.3e-17 63.7 4.3 1.8e-17 63.3 4.3 1.2 1 0 0 1 1 1 1 Proteolipid membrane potential modulator Na_Ca_ex PF01699.24 EMD69376.1 - 3.1e-42 144.1 39.7 2.8e-22 79.3 7.7 2.4 3 0 0 3 3 3 2 Sodium/calcium exchanger protein SNF2_N PF00176.23 EMD69377.1 - 3.6e-51 173.9 0.1 6.2e-51 173.2 0.1 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EMD69377.1 - 2.6e-12 47.0 0.0 6.1e-12 45.9 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-RING_5 PF14634.6 EMD69377.1 - 0.0013 18.6 9.3 0.0029 17.5 9.3 1.6 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EMD69377.1 - 0.0019 18.0 5.3 0.0019 18.0 5.3 2.1 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 EMD69377.1 - 0.56 10.1 9.8 1.4 8.9 9.8 1.7 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMD69377.1 - 1 9.3 10.9 3.3 7.7 10.9 2.0 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EMD69377.1 - 1.2 9.2 5.9 3.1 7.9 5.9 1.8 1 0 0 1 1 1 0 RING-type zinc-finger Fungal_trans PF04082.18 EMD69378.1 - 4.3e-40 137.4 0.0 6.7e-40 136.8 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD69378.1 - 5.4e-09 36.0 8.3 1.4e-08 34.7 8.3 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF4503 PF14951.6 EMD69378.1 - 0.0084 14.6 0.0 0.014 13.9 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4503) Glyco_hydro_61 PF03443.14 EMD69380.1 - 1.1e-51 175.7 0.0 2e-51 174.8 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 Rib_5-P_isom_A PF06026.14 EMD69381.1 - 5.5e-41 140.1 0.0 1.1e-40 139.1 0.0 1.4 1 1 0 1 1 1 1 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) DeoRC PF00455.22 EMD69381.1 - 0.0043 17.0 0.7 1.5 8.7 0.1 2.4 2 1 0 3 3 3 2 DeoR C terminal sensor domain Sugar-bind PF04198.13 EMD69381.1 - 0.038 13.1 0.0 0.065 12.4 0.0 1.3 1 0 0 1 1 1 0 Putative sugar-binding domain ThiF PF00899.21 EMD69382.1 - 1.5e-12 47.4 0.0 2.6e-12 46.6 0.0 1.4 1 1 0 1 1 1 1 ThiF family zf-C3HC4_2 PF13923.6 EMD69383.1 - 1e-08 34.8 12.7 1e-08 34.8 12.7 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EMD69383.1 - 5.7e-06 26.2 17.6 1.9e-05 24.5 14.6 2.3 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4 PF00097.25 EMD69383.1 - 6.6e-06 25.9 15.0 6.6e-06 25.9 15.0 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EMD69383.1 - 1.7e-05 24.7 11.5 1.7e-05 24.7 11.5 2.4 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EMD69383.1 - 5.8e-05 22.9 18.2 0.00019 21.2 14.3 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.6 EMD69383.1 - 5.8e-05 22.9 8.8 5.8e-05 22.9 8.8 2.2 2 0 0 2 2 2 1 zf-RING of BARD1-type protein SAP PF02037.27 EMD69383.1 - 7.6e-05 22.4 0.0 0.00023 20.9 0.0 1.9 2 0 0 2 2 2 1 SAP domain U-box PF04564.15 EMD69383.1 - 9e-05 22.6 0.1 0.0003 20.9 0.0 2.0 2 0 0 2 2 2 1 U-box domain zf-C3HC4_4 PF15227.6 EMD69383.1 - 0.0011 19.1 14.2 0.0011 19.1 14.2 2.1 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 EMD69383.1 - 0.0013 19.1 14.4 0.0013 19.1 14.4 2.2 2 0 0 2 2 2 1 Ring finger domain Prok-RING_4 PF14447.6 EMD69383.1 - 0.0054 16.6 17.1 0.13 12.2 15.2 2.3 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 EMD69383.1 - 0.026 14.8 8.0 0.026 14.8 8.0 2.2 2 0 0 2 2 2 0 RING-H2 zinc finger domain Mob_synth_C PF06463.13 EMD69383.1 - 0.11 12.5 4.4 0.36 10.8 4.4 1.9 1 0 0 1 1 1 0 Molybdenum Cofactor Synthesis C Rad50_zn_hook PF04423.14 EMD69383.1 - 0.17 11.8 2.6 1.3 8.9 0.1 2.8 2 0 0 2 2 2 0 Rad50 zinc hook motif zf-RING_10 PF16685.5 EMD69383.1 - 1.6 8.9 13.3 0.19 11.9 9.0 1.7 2 0 0 2 2 1 0 zinc RING finger of MSL2 DTHCT PF08070.11 EMD69383.1 - 1.8 9.3 12.2 1.3 9.8 2.7 2.7 2 0 0 2 2 2 0 DTHCT (NUC029) region DEAD PF00270.29 EMD69384.1 - 2.4e-43 147.9 0.2 3.8e-43 147.3 0.2 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EMD69384.1 - 3.1e-21 75.8 0.1 1.3e-20 73.7 0.0 2.2 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EMD69384.1 - 5.1e-17 61.9 0.9 1.1e-16 60.8 0.9 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 EMD69384.1 - 5e-07 29.9 0.0 1.4e-06 28.4 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EMD69384.1 - 0.00024 20.4 0.8 0.00042 19.6 0.0 1.7 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase Vfa1 PF08432.10 EMD69384.1 - 0.066 13.5 2.7 0.22 11.8 2.7 1.8 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 RXT2_N PF08595.11 EMD69384.1 - 0.15 12.1 4.4 0.057 13.4 1.1 1.9 2 0 0 2 2 2 0 RXT2-like, N-terminal FAM176 PF14851.6 EMD69384.1 - 0.25 11.0 1.1 0.59 9.8 1.1 1.6 1 0 0 1 1 1 0 FAM176 family CPSF100_C PF13299.6 EMD69384.1 - 0.7 10.1 4.3 0.67 10.1 0.3 2.4 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Pantoate_ligase PF02569.15 EMD69385.1 - 4.3e-91 304.8 0.0 5.1e-91 304.6 0.0 1.0 1 0 0 1 1 1 1 Pantoate-beta-alanine ligase ATP-sulfurylase PF01747.17 EMD69385.1 - 0.11 11.9 0.0 0.17 11.3 0.0 1.2 1 0 0 1 1 1 0 ATP-sulfurylase Aldedh PF00171.22 EMD69387.1 - 2.6e-129 431.7 0.0 2.9e-129 431.6 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 EMD69387.1 - 6.1e-05 22.2 0.0 0.0013 17.9 0.0 2.1 2 0 0 2 2 2 2 Acyl-CoA reductase (LuxC) Ogr_Delta PF04606.12 EMD69389.1 - 0.0063 16.5 0.1 0.0076 16.2 0.1 1.2 1 0 0 1 1 1 1 Ogr/Delta-like zinc finger RRM_DME PF15628.6 EMD69389.1 - 0.058 13.6 0.1 0.065 13.4 0.1 1.2 1 1 0 1 1 1 0 RRM in Demeter Fungal_trans PF04082.18 EMD69391.1 - 2.7e-31 108.6 0.1 3.4e-30 105.0 0.1 2.4 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD69391.1 - 6.5e-08 32.6 9.3 1.3e-07 31.6 9.3 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MGC-24 PF05283.11 EMD69391.1 - 0.46 10.9 4.4 1.2 9.6 4.4 1.7 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin Nipped-B_C PF12830.7 EMD69394.1 - 9.9e-44 149.6 2.4 7.8e-42 143.4 0.2 3.2 4 0 0 4 4 4 2 Sister chromatid cohesion C-terminus Cohesin_HEAT PF12765.7 EMD69394.1 - 1e-10 41.7 0.5 5.6e-10 39.3 0.5 2.3 2 0 0 2 2 2 1 HEAT repeat associated with sister chromatid cohesion Cnd1 PF12717.7 EMD69394.1 - 1.3e-05 25.4 0.1 8.3e-05 22.7 0.1 2.5 1 1 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 EMD69394.1 - 0.0059 16.8 0.4 1.8 9.1 0.1 4.2 4 0 0 4 4 4 1 HEAT repeat Adaptin_N PF01602.20 EMD69394.1 - 0.055 12.0 5.0 0.26 9.8 0.2 3.7 5 1 1 6 6 6 0 Adaptin N terminal region HEAT_2 PF13646.6 EMD69395.1 - 7.5e-29 100.0 4.2 3e-12 46.7 0.0 3.7 2 2 2 4 4 4 3 HEAT repeats HEAT_PBS PF03130.16 EMD69395.1 - 2.5e-21 74.1 2.1 0.0054 17.3 0.1 6.2 6 0 0 6 6 6 5 PBS lyase HEAT-like repeat HEAT PF02985.22 EMD69395.1 - 6.8e-08 32.1 4.1 1.2 9.6 0.0 6.2 7 0 0 7 7 7 3 HEAT repeat HEAT_EZ PF13513.6 EMD69395.1 - 1.2e-05 25.6 7.5 1.5 9.4 0.0 6.0 4 2 3 7 7 7 2 HEAT-like repeat Cnd1 PF12717.7 EMD69395.1 - 0.015 15.3 0.0 2.6 8.1 0.0 3.3 2 2 2 4 4 4 0 non-SMC mitotic condensation complex subunit 1 Arm PF00514.23 EMD69395.1 - 0.06 13.4 1.3 13 6.0 0.0 3.3 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat PUB_1 PF18486.1 EMD69395.1 - 0.076 12.9 0.6 0.39 10.6 0.1 2.4 2 0 0 2 2 2 0 PNGase/UBA- or UBX-containing domain Vitellogenin_N PF01347.22 EMD69395.1 - 0.13 10.6 0.0 31 2.8 0.0 2.9 3 0 0 3 3 3 0 Lipoprotein amino terminal region DUF3533 PF12051.8 EMD69397.1 - 4.4e-115 384.6 18.4 5.1e-115 384.4 18.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3533) VIT1 PF01988.19 EMD69397.1 - 0.12 12.2 2.3 0.17 11.7 0.0 2.1 2 0 0 2 2 2 0 VIT family Glyco_hydro_2_N PF02837.18 EMD69398.1 - 3.1e-15 56.5 0.4 9.7e-14 51.6 0.4 2.6 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2_C PF02836.17 EMD69398.1 - 1.2e-11 44.3 0.3 5e-10 39.0 0.2 2.8 2 1 0 2 2 2 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_2 PF00703.21 EMD69398.1 - 5.1e-09 36.8 0.2 3.2e-08 34.2 0.0 2.2 2 0 0 2 2 2 1 Glycosyl hydrolases family 2 DUF2293 PF10056.9 EMD69399.1 - 6.7e-31 106.4 0.1 1.5e-30 105.2 0.1 1.7 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2293) Glyco_trans_4_2 PF13477.6 EMD69399.1 - 0.02 14.9 0.0 0.036 14.1 0.0 1.3 1 0 0 1 1 1 0 Glycosyl transferase 4-like NFACT-R_1 PF05670.13 EMD69400.1 - 1.8e-41 141.2 0.2 2.7e-41 140.6 0.2 1.3 1 0 0 1 1 1 1 NFACT protein RNA binding domain DUF5568 PF17724.1 EMD69401.1 - 0.05 13.4 1.3 0.056 13.3 1.3 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5568) Connexin PF00029.19 EMD69401.1 - 0.13 12.0 1.1 0.14 11.9 1.1 1.2 1 0 0 1 1 1 0 Connexin Peptidase_S49_N PF08496.10 EMD69401.1 - 0.32 11.1 4.6 0.38 10.8 4.6 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal DUF3464 PF11947.8 EMD69401.1 - 1.1 9.0 3.3 1.5 8.5 3.3 1.2 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 THAP PF05485.12 EMD69401.1 - 1.3 10.0 8.0 3.6 8.6 8.0 1.7 1 1 0 1 1 1 0 THAP domain Ferlin_C PF16165.5 EMD69401.1 - 8.6 6.3 8.0 11 5.9 8.0 1.1 1 0 0 1 1 1 0 Ferlin C-terminus MARVEL PF01284.23 EMD69402.1 - 0.16 12.0 15.7 0.44 10.6 15.5 1.7 1 1 0 1 1 1 0 Membrane-associating domain Amidase PF01425.21 EMD69403.1 - 1.3e-97 327.6 0.0 2.1e-97 327.0 0.0 1.3 1 1 0 1 1 1 1 Amidase NB-ARC PF00931.22 EMD69403.1 - 0.081 12.1 0.0 0.13 11.4 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain GFA PF04828.14 EMD69404.1 - 3.2e-13 49.8 0.5 3.2e-13 49.8 0.5 1.9 2 0 0 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme DHHC PF01529.20 EMD69404.1 - 1.3 9.1 7.6 1.3 9.1 1.3 2.1 2 0 0 2 2 2 0 DHHC palmitoyltransferase YyzF PF14116.6 EMD69404.1 - 1.5 8.9 6.3 2.6 8.1 0.7 2.3 2 0 0 2 2 2 0 YyzF-like protein GFA PF04828.14 EMD69405.1 - 3.3e-05 24.2 0.0 0.00011 22.4 0.0 1.7 1 1 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme PMSR PF01625.21 EMD69406.1 - 3.7e-63 212.3 0.5 4.4e-63 212.0 0.5 1.0 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase DUF4360 PF14273.6 EMD69407.1 - 9.8e-70 234.0 5.0 1.1e-69 233.9 5.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4360) Kinesin PF00225.23 EMD69408.1 - 3.2e-118 394.5 0.1 4.4e-118 394.0 0.1 1.2 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EMD69408.1 - 2.2e-27 95.8 0.0 5.5e-27 94.5 0.0 1.7 1 0 0 1 1 1 1 Microtubule binding Herpes_UL14 PF03580.14 EMD69408.1 - 0.0081 16.4 1.5 0.026 14.8 1.5 1.8 1 0 0 1 1 1 1 Herpesvirus UL14-like protein AAA_33 PF13671.6 EMD69408.1 - 0.077 13.2 0.0 0.32 11.1 0.0 2.1 1 0 0 1 1 1 0 AAA domain ADH_zinc_N PF00107.26 EMD69409.1 - 6e-06 26.3 0.3 0.0001 22.3 0.2 2.2 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EMD69409.1 - 4.5e-05 23.3 0.1 0.00018 21.4 0.1 2.0 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 EMD69409.1 - 0.0064 17.5 0.0 0.014 16.5 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase NPCBM_assoc PF10633.9 EMD69409.1 - 0.42 10.9 2.4 2.7 8.3 0.0 3.0 3 0 0 3 3 3 0 NPCBM-associated, NEW3 domain of alpha-galactosidase Bac_rhamnosid6H PF17389.2 EMD69410.1 - 8.1e-18 64.8 0.2 2.1e-17 63.4 0.2 1.6 2 0 0 2 2 2 1 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain Bac_rhamnosid_C PF17390.2 EMD69410.1 - 3.8e-08 33.0 0.3 1.4e-07 31.2 0.2 2.1 2 0 0 2 2 2 1 Bacterial alpha-L-rhamnosidase C-terminal domain Bac_rhamnosid PF05592.11 EMD69410.1 - 0.017 15.1 0.4 0.11 12.5 0.0 2.2 2 0 0 2 2 2 0 Bacterial alpha-L-rhamnosidase concanavalin-like domain NUDIX PF00293.28 EMD69411.1 - 3e-07 30.5 0.0 6.2e-07 29.5 0.0 1.6 1 0 0 1 1 1 1 NUDIX domain Arm_APC_u3 PF16629.5 EMD69411.1 - 0.16 11.6 0.0 0.24 11.0 0.0 1.2 1 0 0 1 1 1 0 Armadillo-associated region on APC IMPDH PF00478.25 EMD69412.1 - 1.5e-128 428.7 3.6 1.7e-128 428.4 3.6 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain CBS PF00571.28 EMD69412.1 - 3.1e-15 56.3 0.0 4.7e-06 26.9 0.0 2.4 2 0 0 2 2 2 2 CBS domain NMO PF03060.15 EMD69412.1 - 8e-07 28.7 5.0 0.022 14.2 5.9 2.9 2 1 1 3 3 3 2 Nitronate monooxygenase FMN_dh PF01070.18 EMD69412.1 - 1.5e-05 24.2 0.5 4.2e-05 22.7 0.2 1.9 2 0 0 2 2 2 1 FMN-dependent dehydrogenase His_biosynth PF00977.21 EMD69412.1 - 0.00075 19.0 1.7 0.013 14.9 1.7 2.4 1 1 0 1 1 1 1 Histidine biosynthesis protein YpsA PF06908.11 EMD69412.1 - 0.0098 15.9 0.0 0.018 15.0 0.0 1.3 1 0 0 1 1 1 1 YspA SLOG family PK PF00224.21 EMD69412.1 - 0.03 13.2 0.0 0.093 11.6 0.0 1.6 1 1 0 1 1 1 0 Pyruvate kinase, barrel domain ThiG PF05690.14 EMD69412.1 - 0.048 13.0 1.1 0.066 12.5 0.2 1.6 2 0 0 2 2 2 0 Thiazole biosynthesis protein ThiG RasGAP PF00616.19 EMD69413.1 - 9.1e-51 172.5 0.0 2.1e-50 171.3 0.0 1.7 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase RasGAP_C PF03836.15 EMD69413.1 - 8.1e-48 162.0 4.3 3.4e-47 160.0 4.3 2.2 1 0 0 1 1 1 1 RasGAP C-terminus IQ PF00612.27 EMD69413.1 - 4.9e-14 50.7 60.3 0.019 14.7 0.6 14.5 16 0 0 16 16 16 7 IQ calmodulin-binding motif CH PF00307.31 EMD69413.1 - 8.3e-09 35.6 0.0 3.3e-08 33.7 0.0 2.0 1 0 0 1 1 1 1 Calponin homology (CH) domain Trypan_PARP PF05887.11 EMD69413.1 - 0.014 15.4 0.0 0.036 14.1 0.0 1.6 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) MFS_1 PF07690.16 EMD69414.1 - 6.9e-09 35.1 25.0 6.9e-09 35.1 25.0 1.9 1 1 0 1 1 1 1 Major Facilitator Superfamily LicD PF04991.13 EMD69415.1 - 2.6e-15 57.2 13.4 1e-09 38.9 3.7 3.2 1 1 1 3 3 3 3 LicD family DUF3405 PF11885.8 EMD69416.1 - 3.4e-204 679.2 19.7 9.8e-203 674.4 19.7 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF3405) CBM_5_12_2 PF14600.6 EMD69416.1 - 2.9 7.9 6.8 0.58 10.1 1.9 2.3 2 0 0 2 2 2 0 Cellulose-binding domain tRNA-synt_2d PF01409.20 EMD69417.1 - 3.8e-85 285.3 0.0 4.9e-85 284.9 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) PheRS_DBD3 PF18553.1 EMD69417.1 - 1.1e-14 54.4 1.4 2e-14 53.6 0.2 2.1 2 0 0 2 2 2 1 PheRS DNA binding domain 3 tRNA-synt_2 PF00152.20 EMD69417.1 - 3.7e-06 26.2 0.4 0.0042 16.2 0.1 3.2 3 0 0 3 3 3 2 tRNA synthetases class II (D, K and N) tRNA_synthFbeta PF17759.1 EMD69417.1 - 9.4e-06 25.2 0.0 0.014 14.9 0.0 2.4 2 0 0 2 2 2 2 Phenylalanyl tRNA synthetase beta chain CLM domain Tim17 PF02466.19 EMD69418.1 - 1.8e-05 25.1 0.6 2.9e-05 24.4 0.6 1.4 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Bacteriocin_IIc PF10439.9 EMD69418.1 - 0.027 14.6 1.0 0.027 14.6 1.0 2.0 2 0 0 2 2 2 0 Bacteriocin class II with double-glycine leader peptide LapA_dom PF06305.11 EMD69418.1 - 2.5 8.0 7.3 8.6 6.3 0.0 3.0 2 1 1 3 3 3 0 Lipopolysaccharide assembly protein A domain NmrA PF05368.13 EMD69420.1 - 8.2e-37 127.0 0.0 1e-36 126.7 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EMD69420.1 - 2.3e-08 34.1 0.0 3.5e-08 33.6 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Zn_clus PF00172.18 EMD69421.1 - 1e-07 31.9 11.5 1.7e-07 31.2 11.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EMD69421.1 - 2.6e-05 23.4 3.2 7.2e-05 21.9 0.0 2.2 2 0 0 2 2 2 1 Fungal specific transcription factor domain Anth_Ig PF05587.13 EMD69421.1 - 0.039 14.3 0.0 0.081 13.2 0.0 1.5 1 0 0 1 1 1 0 Anthrax receptor extracellular domain DUF1388 PF07142.12 EMD69421.1 - 3.4 7.7 8.5 0.19 11.7 0.8 2.5 2 0 0 2 2 2 0 Repeat of unknown function (DUF1388) ThiS PF02597.20 EMD69422.1 - 1.3e-11 45.0 0.0 1.4e-11 44.8 0.0 1.0 1 0 0 1 1 1 1 ThiS family RNB PF00773.19 EMD69423.1 - 2e-55 188.4 0.0 4.7e-55 187.2 0.0 1.6 1 0 0 1 1 1 1 RNB domain Fungal_trans PF04082.18 EMD69425.1 - 1.5e-18 66.8 0.0 4e-18 65.4 0.0 1.7 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD69425.1 - 2.4e-05 24.3 11.1 5.2e-05 23.3 11.1 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain NAD_binding_8 PF13450.6 EMD69426.1 - 1.9e-11 44.0 0.0 5.4e-11 42.6 0.0 1.8 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FMO-like PF00743.19 EMD69426.1 - 5.6e-11 41.6 0.2 2.2e-09 36.3 0.1 2.3 2 1 0 2 2 2 1 Flavin-binding monooxygenase-like NAD_binding_9 PF13454.6 EMD69426.1 - 1.4e-05 25.1 0.0 7e-05 22.9 0.0 2.0 2 0 0 2 2 2 1 FAD-NAD(P)-binding K_oxygenase PF13434.6 EMD69426.1 - 0.00072 18.8 0.0 0.8 8.8 0.0 3.2 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.24 EMD69426.1 - 0.003 17.2 0.0 0.12 11.9 0.0 2.6 2 1 0 2 2 2 1 FAD dependent oxidoreductase Aldedh PF00171.22 EMD69428.1 - 1.2e-161 538.4 0.1 1.3e-161 538.2 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 EMD69428.1 - 0.0056 16.1 0.0 0.047 13.1 0.0 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF1487) OmdA PF13376.6 EMD69428.1 - 0.075 13.1 0.2 0.17 11.9 0.2 1.5 1 0 0 1 1 1 0 Bacteriocin-protection, YdeI or OmpD-Associated adh_short PF00106.25 EMD69429.1 - 4.5e-31 107.8 0.0 1.1e-30 106.6 0.0 1.6 2 1 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD69429.1 - 9.3e-22 77.7 0.0 2e-21 76.6 0.0 1.5 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 EMD69429.1 - 0.0011 18.5 0.0 0.0016 18.0 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family KR PF08659.10 EMD69429.1 - 0.0013 18.6 0.0 0.0036 17.2 0.0 1.6 2 0 0 2 2 2 1 KR domain Caskin-Pro-rich PF16907.5 EMD69429.1 - 0.017 15.7 0.0 0.029 14.9 0.0 1.4 1 0 0 1 1 1 0 Proline rich region of Caskin proteins Sacchrp_dh_NADP PF03435.18 EMD69429.1 - 0.03 14.6 0.0 0.064 13.5 0.0 1.5 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain 3Beta_HSD PF01073.19 EMD69429.1 - 0.032 13.2 0.0 0.058 12.4 0.0 1.4 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family TrkA_N PF02254.18 EMD69429.1 - 0.045 14.0 0.0 0.082 13.2 0.0 1.3 1 0 0 1 1 1 0 TrkA-N domain DUF4783 PF16022.5 EMD69429.1 - 0.073 13.2 0.2 0.15 12.3 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4783) Methyltransf_25 PF13649.6 EMD69429.1 - 0.17 12.6 0.1 0.38 11.5 0.1 1.5 1 0 0 1 1 1 0 Methyltransferase domain adh_short_C2 PF13561.6 EMD69430.1 - 5e-49 167.0 0.0 6e-49 166.7 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EMD69430.1 - 2.2e-40 138.2 0.0 2.9e-40 137.8 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EMD69430.1 - 2.9e-11 43.6 0.1 3.8e-11 43.2 0.1 1.2 1 0 0 1 1 1 1 KR domain Tex_YqgF PF16921.5 EMD69430.1 - 0.014 15.8 0.0 3.8 8.0 0.0 2.2 2 0 0 2 2 2 0 Tex protein YqgF-like domain Gag_p10 PF02337.17 EMD69430.1 - 0.053 13.5 0.0 0.099 12.6 0.0 1.4 1 0 0 1 1 1 0 Retroviral GAG p10 protein Epimerase PF01370.21 EMD69430.1 - 0.086 12.3 0.0 0.19 11.2 0.0 1.7 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EMD69430.1 - 0.16 11.4 0.0 15 4.8 0.0 2.1 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase AMP-binding PF00501.28 EMD69431.1 - 4e-81 272.8 0.0 5.4e-81 272.4 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EMD69431.1 - 1.1e-10 42.3 2.0 1.2e-10 42.3 0.3 1.9 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain ADH_zinc_N PF00107.26 EMD69432.1 - 1.5e-23 83.2 0.0 2.7e-23 82.4 0.0 1.4 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EMD69432.1 - 2.6e-17 62.7 0.4 4.2e-17 62.0 0.4 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain AlaDh_PNT_C PF01262.21 EMD69432.1 - 0.00074 18.9 0.0 0.0012 18.2 0.0 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.19 EMD69432.1 - 0.0013 18.1 0.0 0.0024 17.2 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain CMAS PF02353.20 EMD69432.1 - 0.01 15.1 0.0 0.017 14.5 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase ThiF PF00899.21 EMD69432.1 - 0.017 14.5 0.1 0.028 13.8 0.1 1.2 1 0 0 1 1 1 0 ThiF family TrkA_N PF02254.18 EMD69432.1 - 0.028 14.7 0.0 0.044 14.0 0.0 1.3 1 0 0 1 1 1 0 TrkA-N domain Methyltransf_25 PF13649.6 EMD69432.1 - 0.028 15.1 0.0 0.064 14.0 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.12 EMD69432.1 - 0.033 14.8 0.0 0.085 13.5 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain 3HCDH_N PF02737.18 EMD69432.1 - 0.16 11.9 0.0 0.32 10.8 0.0 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Abhydrolase_3 PF07859.13 EMD69433.1 - 2.5e-44 151.7 0.1 3.1e-44 151.4 0.1 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 EMD69433.1 - 2.9e-07 29.8 0.0 1.1e-06 27.9 0.0 1.7 2 0 0 2 2 2 1 Carboxylesterase family Esterase PF00756.20 EMD69433.1 - 0.0048 16.6 0.0 0.046 13.4 0.0 2.0 1 1 0 1 1 1 1 Putative esterase Acyl-CoA_dh_1 PF00441.24 EMD69434.1 - 7.8e-24 84.6 0.2 1.3e-23 83.9 0.2 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 EMD69434.1 - 9.8e-12 45.5 0.0 2.1e-11 44.5 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 EMD69434.1 - 9.2e-07 29.2 0.0 1.6e-06 28.5 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 EMD69434.1 - 2.4e-06 27.6 0.0 8.1e-06 26.0 0.0 1.8 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, middle domain RNA_pol_Rbc25 PF08292.12 EMD69434.1 - 0.041 14.1 0.0 0.076 13.3 0.0 1.3 1 0 0 1 1 1 0 RNA polymerase III subunit Rpc25 adh_short_C2 PF13561.6 EMD69435.1 - 7.3e-55 186.1 0.2 9.2e-55 185.7 0.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EMD69435.1 - 1.7e-43 148.4 0.2 2.1e-43 148.0 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EMD69435.1 - 3.9e-09 36.7 0.0 5.2e-09 36.3 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EMD69435.1 - 5.7e-07 29.2 0.2 1.7e-06 27.7 0.2 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family ThiF PF00899.21 EMD69435.1 - 0.0073 15.7 0.0 0.054 12.8 0.0 2.1 1 1 1 2 2 2 1 ThiF family Ldh_1_N PF00056.23 EMD69435.1 - 0.021 14.9 0.3 0.073 13.2 0.0 1.9 2 0 0 2 2 2 0 lactate/malate dehydrogenase, NAD binding domain Adenylsucc_synt PF00709.21 EMD69435.1 - 0.037 13.0 0.0 0.064 12.2 0.0 1.4 1 1 0 1 1 1 0 Adenylosuccinate synthetase DNA_pol_lambd_f PF10391.9 EMD69435.1 - 0.048 13.5 0.0 0.16 11.8 0.0 1.9 2 0 0 2 2 2 0 Fingers domain of DNA polymerase lambda Chordopox_A35R PF05989.12 EMD69435.1 - 0.075 12.9 0.0 0.12 12.3 0.0 1.2 1 0 0 1 1 1 0 Chordopoxvirus A35R protein FMO-like PF00743.19 EMD69436.1 - 5.5e-13 48.2 0.0 3.9e-10 38.8 0.1 2.4 2 1 0 2 2 2 2 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.6 EMD69436.1 - 2.6e-12 46.8 0.0 6e-12 45.6 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 EMD69436.1 - 4.4e-06 26.2 0.0 3.8e-05 23.1 0.0 2.3 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EMD69436.1 - 3.6e-05 23.1 0.0 0.014 14.6 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EMD69436.1 - 0.0002 20.6 0.0 0.24 10.5 0.0 3.0 3 1 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.24 EMD69436.1 - 0.00063 19.4 0.0 0.22 11.1 0.0 3.0 2 1 0 3 3 3 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EMD69436.1 - 0.0015 18.5 0.0 0.0076 16.2 0.0 2.2 2 0 0 2 2 2 1 FAD-NAD(P)-binding HI0933_like PF03486.14 EMD69436.1 - 0.094 11.4 0.0 0.19 10.4 0.0 1.5 1 0 0 1 1 1 0 HI0933-like protein Dioxygenase_C PF00775.21 EMD69438.1 - 1.7e-05 24.4 0.0 2.6e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 Dioxygenase GPHR_N PF12537.8 EMD69439.1 - 0.007 16.4 0.0 0.034 14.2 0.0 2.2 1 0 0 1 1 1 1 The Golgi pH Regulator (GPHR) Family N-terminal Bax1-I PF01027.20 EMD69440.1 - 4e-35 121.5 9.2 5.5e-35 121.1 9.2 1.2 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 Sugar_tr PF00083.24 EMD69442.1 - 1.2e-32 113.4 23.5 2.3e-31 109.2 23.5 2.1 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD69442.1 - 3.4e-32 111.8 46.6 5.9e-30 104.4 27.5 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF1156 PF06634.12 EMD69442.1 - 0.019 15.1 0.0 0.048 13.8 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1156) HeLo PF14479.6 EMD69443.1 - 4.9e-46 157.2 0.1 1e-45 156.1 0.1 1.5 1 0 0 1 1 1 1 Prion-inhibition and propagation NACHT PF05729.12 EMD69443.1 - 5.8e-08 32.8 0.2 2e-07 31.1 0.0 1.9 2 0 0 2 2 2 1 NACHT domain AAA_16 PF13191.6 EMD69443.1 - 1e-06 29.3 0.3 6.1e-05 23.5 0.0 3.0 3 0 0 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 EMD69443.1 - 7.9e-06 26.2 0.0 2.8e-05 24.4 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EMD69443.1 - 0.01 16.4 0.0 0.028 15.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EMD69443.1 - 0.015 15.7 0.1 0.036 14.5 0.1 1.7 1 0 0 1 1 1 0 RNA helicase AAA_29 PF13555.6 EMD69443.1 - 0.028 14.2 0.3 0.058 13.1 0.3 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.27 EMD69443.1 - 0.031 14.8 0.1 0.12 12.9 0.1 1.9 1 0 0 1 1 1 0 ABC transporter AAA_33 PF13671.6 EMD69443.1 - 0.061 13.5 0.3 0.19 11.9 0.0 2.0 2 0 0 2 2 2 0 AAA domain Viral_helicase1 PF01443.18 EMD69443.1 - 0.073 12.8 0.0 0.18 11.5 0.0 1.6 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA PF00004.29 EMD69443.1 - 0.089 13.2 0.1 0.62 10.5 0.1 2.5 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) MMR_HSR1 PF01926.23 EMD69443.1 - 0.096 12.8 0.0 0.23 11.6 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_24 PF13479.6 EMD69443.1 - 0.12 12.1 0.2 1.1 8.9 0.1 2.2 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 EMD69443.1 - 0.13 11.4 0.0 0.31 10.2 0.0 1.6 1 0 0 1 1 1 0 NB-ARC domain AAA_30 PF13604.6 EMD69443.1 - 0.13 12.0 0.0 0.27 10.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain cNMPbd_u2 PF16643.5 EMD69444.1 - 2.2e-46 158.2 10.0 2.2e-46 158.2 10.0 1.9 2 0 0 2 2 2 1 Unstructured region on cNMP-binding protein cNMP_binding PF00027.29 EMD69444.1 - 1.2e-31 108.6 0.0 2.4e-18 66.0 0.0 3.0 2 1 0 2 2 2 2 Cyclic nucleotide-binding domain LRR_6 PF13516.6 EMD69444.1 - 1.9e-08 33.7 7.2 1 9.6 0.0 7.6 9 0 0 9 9 9 2 Leucine Rich repeat LRR_4 PF12799.7 EMD69444.1 - 2.8e-07 30.8 0.4 0.34 11.4 0.2 5.7 2 1 6 8 8 8 2 Leucine Rich repeats (2 copies) F-box-like PF12937.7 EMD69444.1 - 0.00092 19.1 0.7 0.0034 17.2 0.1 2.2 2 0 0 2 2 2 1 F-box-like LRR_1 PF00560.33 EMD69444.1 - 0.005 17.2 5.2 2.4e+02 3.0 0.2 6.9 7 1 0 7 7 7 0 Leucine Rich Repeat F-box PF00646.33 EMD69444.1 - 0.0068 16.3 0.4 0.0068 16.3 0.4 3.3 4 0 0 4 4 4 1 F-box domain LRR_8 PF13855.6 EMD69444.1 - 0.023 14.5 0.1 15 5.5 0.0 3.2 2 1 0 2 2 2 0 Leucine rich repeat SAM_Ste50p PF09235.10 EMD69444.1 - 0.052 13.8 0.1 7.2 6.9 0.0 3.3 3 0 0 3 3 3 0 Ste50p, sterile alpha motif Rick_17kDa_Anti PF05433.15 EMD69445.1 - 1.2e-06 28.3 13.3 2.1e-06 27.5 13.3 1.4 1 0 0 1 1 1 1 Glycine zipper 2TM domain Gly-zipper_YMGG PF13441.6 EMD69445.1 - 0.034 13.9 9.5 0.064 13.0 9.5 1.4 1 0 0 1 1 1 0 YMGG-like Gly-zipper DUF533 PF04391.12 EMD69445.1 - 0.14 11.7 2.3 0.26 10.9 2.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF533) TraT PF05818.12 EMD69445.1 - 0.15 11.8 1.8 0.23 11.1 1.8 1.3 1 0 0 1 1 1 0 Enterobacterial TraT complement resistance protein Gly-zipper_Omp PF13488.6 EMD69445.1 - 0.3 11.1 13.4 0.15 12.0 4.8 2.2 1 1 1 2 2 2 0 Glycine zipper Ribonucleas_3_3 PF14622.6 EMD69446.1 - 1.6e-08 34.8 0.0 2.8e-08 34.0 0.0 1.3 1 0 0 1 1 1 1 Ribonuclease-III-like Ribonuclease_3 PF00636.26 EMD69446.1 - 5e-07 30.3 0.0 3.1e-06 27.7 0.0 2.0 1 1 0 1 1 1 1 Ribonuclease III domain Ribonucleas_3_3 PF14622.6 EMD69447.1 - 3.9e-10 40.0 0.0 6e-10 39.4 0.0 1.4 1 0 0 1 1 1 1 Ribonuclease-III-like Ribonuclease_3 PF00636.26 EMD69447.1 - 1.2e-09 38.8 0.1 1.3e-08 35.4 0.1 2.2 1 1 0 1 1 1 1 Ribonuclease III domain RNase_PH PF01138.21 EMD69448.1 - 9.3e-37 126.5 0.1 1.6e-36 125.7 0.1 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 EMD69448.1 - 0.0032 17.5 0.1 0.0051 16.8 0.1 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 SNF2_N PF00176.23 EMD69449.1 - 2.2e-53 181.2 0.0 4.2e-53 180.3 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EMD69449.1 - 1.5e-21 76.9 0.0 1e-17 64.5 0.0 4.1 4 0 0 4 4 4 2 Helicase conserved C-terminal domain VIGSSK PF14773.6 EMD69449.1 - 1.4e-17 63.5 1.7 2.6e-17 62.7 0.1 2.3 2 0 0 2 2 2 1 Helicase-associated putative binding domain, C-terminal ResIII PF04851.15 EMD69449.1 - 2e-09 37.7 0.0 6.7e-09 36.0 0.0 1.9 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EMD69449.1 - 9.6e-06 25.0 0.1 2.2e-05 23.8 0.1 1.6 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase DEAD PF00270.29 EMD69449.1 - 7.1e-05 22.6 0.0 0.00014 21.7 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase p450 PF00067.22 EMD69450.1 - 1.9e-55 188.4 0.0 3.7e-55 187.5 0.0 1.3 1 1 0 1 1 1 1 Cytochrome P450 PSI_8 PF00796.18 EMD69450.1 - 0.084 12.7 2.8 0.17 11.7 2.8 1.5 1 0 0 1 1 1 0 Photosystem I reaction centre subunit VIII Glyco_hydro_3 PF00933.21 EMD69451.1 - 5.9e-45 154.0 0.0 8.7e-45 153.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.22 EMD69451.1 - 8.6e-06 25.8 0.1 0.00021 21.3 0.0 2.5 1 1 2 3 3 3 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_28 PF00295.17 EMD69453.1 - 1.5e-53 182.0 13.4 3.6e-53 180.7 13.4 1.5 1 1 0 1 1 1 1 Glycosyl hydrolases family 28 Forkhead PF00250.18 EMD69454.1 - 2.9e-24 85.1 0.1 5.3e-24 84.3 0.1 1.4 1 0 0 1 1 1 1 Forkhead domain Cactin_mid PF10312.9 EMD69455.1 - 1.5e-59 201.1 10.5 1.8e-59 200.8 6.1 2.2 1 1 1 2 2 2 1 Conserved mid region of cactin CactinC_cactus PF09732.9 EMD69455.1 - 1.6e-57 192.8 5.3 2.6e-57 192.1 5.3 1.3 1 0 0 1 1 1 1 Cactus-binding C-terminus of cactin protein SF3A2 PF16835.5 EMD69455.1 - 0.024 15.0 0.1 0.083 13.3 0.0 2.0 2 0 0 2 2 2 0 Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) Endonuc-BglII PF09195.11 EMD69455.1 - 0.088 12.6 1.4 9 6.1 0.4 2.4 2 0 0 2 2 2 0 Restriction endonuclease BglII XLF PF09302.11 EMD69456.1 - 6e-46 156.9 0.8 6e-46 156.9 0.8 1.7 2 0 0 2 2 2 1 XLF-Cernunnos, XRcc4-like factor, NHEJ component SET PF00856.28 EMD69459.1 - 4.2e-10 40.3 0.9 7.4e-09 36.2 0.0 3.1 3 1 0 3 3 3 1 SET domain TPR_2 PF07719.17 EMD69459.1 - 1.2e-05 25.1 2.1 0.0064 16.5 0.1 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 EMD69459.1 - 0.0065 16.2 0.3 0.32 10.9 0.1 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 EMD69459.1 - 0.29 11.4 1.6 0.68 10.3 0.6 2.1 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.6 EMD69459.1 - 4.6 8.0 6.2 1.6 9.5 0.1 3.2 3 1 0 3 3 3 0 Tetratricopeptide repeat dCMP_cyt_deam_1 PF00383.23 EMD69460.1 - 1.4e-07 31.4 0.0 2.1e-07 30.7 0.0 1.3 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EMD69460.1 - 2.1e-05 24.3 0.0 3.6e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 MafB19-like deaminase Transketolase_N PF00456.21 EMD69461.1 - 2.7e-117 391.5 0.0 4.1e-117 390.9 0.0 1.2 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.24 EMD69461.1 - 4.5e-43 147.0 0.1 8.6e-43 146.1 0.1 1.5 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 EMD69461.1 - 2.4e-10 40.4 0.0 7.3e-10 38.8 0.0 1.9 1 1 0 1 1 1 1 Transketolase, C-terminal domain DXP_synthase_N PF13292.6 EMD69461.1 - 3.4e-06 26.5 0.8 7.4e-06 25.4 0.0 2.0 2 1 1 3 3 3 1 1-deoxy-D-xylulose-5-phosphate synthase E1_dh PF00676.20 EMD69461.1 - 0.00073 18.6 0.0 0.0018 17.3 0.0 1.7 1 0 0 1 1 1 1 Dehydrogenase E1 component ADH_N PF08240.12 EMD69462.1 - 2.6e-28 98.1 2.8 4e-28 97.5 2.8 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EMD69462.1 - 1.5e-12 47.6 0.0 2.2e-12 47.1 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EMD69462.1 - 2.9e-06 26.9 2.1 4.3e-05 23.1 2.1 2.5 1 1 0 1 1 1 1 Glucose dehydrogenase C-terminus Pyr_redox_2 PF07992.14 EMD69462.1 - 0.032 13.5 0.1 4.6 6.4 0.0 2.6 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase PGAP1 PF07819.13 EMD69463.1 - 0.00067 19.4 0.0 0.018 14.8 0.0 2.4 2 0 0 2 2 2 1 PGAP1-like protein Palm_thioest PF02089.15 EMD69463.1 - 0.04 13.7 0.0 0.2 11.4 0.0 1.9 1 1 1 2 2 2 0 Palmitoyl protein thioesterase Malic_M PF03949.15 EMD69465.1 - 1.1e-95 319.7 0.0 1.7e-95 319.2 0.0 1.2 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 EMD69465.1 - 3.6e-67 225.7 0.0 5.5e-67 225.1 0.0 1.3 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain Integrase_H2C2 PF17921.1 EMD69469.1 - 1.5e-06 28.2 0.0 2.2e-06 27.7 0.0 1.3 1 0 0 1 1 1 1 Integrase zinc binding domain RVP_2 PF08284.11 EMD69470.1 - 0.018 14.8 0.0 0.023 14.5 0.0 1.1 1 0 0 1 1 1 0 Retroviral aspartyl protease Seryl_tRNA_N PF02403.22 EMD69471.1 - 0.02 15.1 0.0 0.021 15.1 0.0 1.1 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Abhydrolase_7 PF12715.7 EMD69471.1 - 0.043 13.1 0.0 0.047 12.9 0.0 1.0 1 0 0 1 1 1 0 Abhydrolase family CCD48 PF15799.5 EMD69471.1 - 0.043 12.1 0.2 0.048 12.0 0.2 1.0 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 48 Salt_tol_Pase PF09506.10 EMD69471.1 - 0.13 10.9 0.1 0.17 10.6 0.1 1.1 1 0 0 1 1 1 0 Glucosylglycerol-phosphate phosphatase (Salt_tol_Pase) PRTase_3 PF15610.6 EMD69473.1 - 1.9e-96 322.4 1.6 2.2e-96 322.2 1.6 1.0 1 0 0 1 1 1 1 PRTase ComF-like p450 PF00067.22 EMD69475.1 - 2e-46 158.7 0.0 2.7e-46 158.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 HTH_Tnp_Tc3_2 PF01498.18 EMD69476.1 - 3e-18 65.8 1.4 4.5e-18 65.3 0.5 1.8 2 0 0 2 2 2 1 Transposase HTH_32 PF13565.6 EMD69476.1 - 2.5e-11 44.0 2.4 3.5e-07 30.7 0.1 2.4 2 0 0 2 2 2 2 Homeodomain-like domain Sigma70_r4 PF04545.16 EMD69476.1 - 5.8e-06 25.7 0.2 0.18 11.4 0.0 2.8 2 1 0 2 2 2 2 Sigma-70, region 4 Sigma70_r4_2 PF08281.12 EMD69476.1 - 1.2e-05 24.9 0.3 0.00054 19.6 0.1 2.2 2 0 0 2 2 2 1 Sigma-70, region 4 DDE_Tnp_ISAZ013 PF07592.11 EMD69476.1 - 1.7e-05 24.0 0.1 2.2e-05 23.6 0.1 1.2 1 0 0 1 1 1 1 Rhodopirellula transposase DDE domain HTH_33 PF13592.6 EMD69476.1 - 7.2e-05 22.4 0.2 0.00045 19.8 0.0 2.2 2 0 0 2 2 2 1 Winged helix-turn helix HTH_23 PF13384.6 EMD69476.1 - 0.00079 19.2 0.0 0.12 12.2 0.0 2.5 2 0 0 2 2 2 1 Homeodomain-like domain HTH_21 PF13276.6 EMD69476.1 - 0.018 15.2 0.6 0.037 14.1 0.0 1.9 2 0 0 2 2 2 0 HTH-like domain UB2H PF14814.6 EMD69476.1 - 0.022 14.8 0.0 0.05 13.6 0.0 1.6 1 0 0 1 1 1 0 Bifunctional transglycosylase second domain HTH_24 PF13412.6 EMD69476.1 - 0.041 13.5 0.0 7.7 6.2 0.0 2.5 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding CENP-B_N PF04218.13 EMD69476.1 - 0.041 13.5 0.0 4.4 7.0 0.0 2.7 2 0 0 2 2 2 0 CENP-B N-terminal DNA-binding domain Glyco_hydro_43 PF04616.14 EMD69478.1 - 3.8e-72 243.0 0.1 4.8e-72 242.7 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 GH43_C2 PF17851.1 EMD69478.1 - 5.7e-11 42.5 0.0 9.8e-11 41.7 0.0 1.4 1 0 0 1 1 1 1 Beta xylosidase C-terminal Concanavalin A-like domain Sugar_tr PF00083.24 EMD69479.1 - 3.1e-78 263.7 17.2 3.6e-78 263.5 17.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD69479.1 - 1.5e-25 89.9 21.7 1.3e-17 63.8 4.6 2.4 1 1 2 3 3 3 3 Major Facilitator Superfamily PATR PF12951.7 EMD69479.1 - 1.1 9.5 3.0 1.8 8.7 0.5 2.2 2 0 0 2 2 2 0 Passenger-associated-transport-repeat HET PF06985.11 EMD69480.1 - 2.8e-37 128.3 2.2 5.3e-37 127.4 2.2 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Peptidase_S28 PF05577.12 EMD69481.1 - 3.9e-47 161.0 0.0 9.2e-47 159.8 0.0 1.5 1 1 0 1 1 1 1 Serine carboxypeptidase S28 Acetyltransf_1 PF00583.25 EMD69482.1 - 0.00011 22.4 0.0 0.00016 21.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EMD69482.1 - 0.0013 19.1 0.0 0.002 18.5 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EMD69482.1 - 0.005 16.8 0.0 0.0076 16.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EMD69482.1 - 0.0074 16.4 0.0 0.017 15.2 0.0 1.7 2 1 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_13 PF13880.6 EMD69482.1 - 0.026 14.5 0.1 0.1 12.6 0.0 1.9 1 1 1 2 2 2 0 ESCO1/2 acetyl-transferase PanZ PF12568.8 EMD69482.1 - 0.073 12.8 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain, PanZ 6PGD PF00393.19 EMD69483.1 - 1.1e-89 300.7 0.0 1.6e-89 300.1 0.0 1.3 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 EMD69483.1 - 8.9e-25 87.7 0.0 1.6e-24 86.8 0.0 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 EMD69483.1 - 0.00089 19.5 0.1 0.0023 18.2 0.1 1.7 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase DUF2714 PF10896.8 EMD69483.1 - 0.03 14.4 0.0 0.054 13.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2714) RRM_1 PF00076.22 EMD69484.1 - 3e-16 59.0 0.0 4.7e-16 58.4 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 EMD69484.1 - 0.0096 15.9 0.1 0.016 15.2 0.1 1.4 1 0 0 1 1 1 1 RNA binding motif RRM_5 PF13893.6 EMD69484.1 - 0.045 13.4 0.0 0.062 12.9 0.0 1.2 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Glyco_hydro_76 PF03663.14 EMD69486.1 - 2.4e-20 73.4 13.9 1.2e-15 58.0 0.7 3.9 2 2 0 2 2 2 2 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 EMD69486.1 - 0.0052 15.9 0.3 0.032 13.3 0.0 2.0 2 0 0 2 2 2 1 Glycosyl Hydrolase Family 88 IBN_N PF03810.19 EMD69487.1 - 3.7e-17 62.0 0.5 1.9e-16 59.7 0.1 2.4 2 0 0 2 2 2 1 Importin-beta N-terminal domain Xpo1 PF08389.12 EMD69487.1 - 0.0082 16.2 3.6 0.0085 16.2 0.1 2.9 4 0 0 4 4 4 1 Exportin 1-like protein DUF3385 PF11865.8 EMD69487.1 - 0.1 12.5 0.4 1.3 8.9 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3385) Pex2_Pex12 PF04757.14 EMD69488.1 - 5.3e-36 124.3 3.3 7.5e-36 123.8 3.3 1.2 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_4 PF15227.6 EMD69488.1 - 0.004 17.3 5.1 0.0076 16.4 5.1 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 EMD69488.1 - 0.086 12.9 2.2 0.3 11.2 2.2 1.9 1 1 0 1 1 1 0 RING-type zinc-finger zf-C2H2_4 PF13894.6 EMD69489.1 - 1.6e-07 31.5 1.6 0.0035 18.1 0.1 2.4 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 EMD69489.1 - 0.00011 22.5 2.8 0.0061 17.0 0.1 2.3 2 0 0 2 2 2 2 Zinc finger, C2H2 type Ima1_N PF09779.9 EMD69489.1 - 0.035 15.0 1.1 0.1 13.5 0.2 2.0 2 0 0 2 2 2 0 Ima1 N-terminal domain zf-Di19 PF05605.12 EMD69489.1 - 0.33 11.3 1.3 4.5 7.6 0.5 2.3 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Peptidase_C12 PF01088.21 EMD69490.1 - 3.1e-53 180.7 0.0 3.5e-53 180.5 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 DUF5401 PF17380.2 EMD69490.1 - 0.078 11.0 0.0 0.095 10.8 0.0 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5401) F-box-like PF12937.7 EMD69491.1 - 4.4e-05 23.3 0.0 0.00014 21.7 0.0 1.9 1 0 0 1 1 1 1 F-box-like F-box-like PF12937.7 EMD69492.1 - 1.9e-06 27.7 0.0 6e-06 26.1 0.0 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EMD69492.1 - 3.5e-06 26.8 0.4 7.2e-05 22.6 0.0 2.7 2 0 0 2 2 2 1 F-box domain F-box-like_2 PF13013.6 EMD69492.1 - 0.054 13.5 0.1 0.13 12.2 0.1 1.6 1 0 0 1 1 1 0 F-box-like domain Utp12 PF04003.12 EMD69492.1 - 0.069 13.5 0.6 13 6.1 0.0 3.4 3 1 0 3 3 3 0 Dip2/Utp12 Family Aldedh PF00171.22 EMD69493.1 - 6.7e-134 446.9 0.4 7.9e-134 446.6 0.4 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 EMD69493.1 - 0.023 13.8 0.0 0.035 13.1 0.0 1.2 1 0 0 1 1 1 0 Acyl-CoA reductase (LuxC) MetW PF07021.12 EMD69493.1 - 0.061 12.9 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Fungal_trans PF04082.18 EMD69495.1 - 4.4e-13 48.9 0.0 2e-12 46.7 0.0 1.9 1 1 0 1 1 1 1 Fungal specific transcription factor domain MFS_1 PF07690.16 EMD69496.1 - 1.9e-33 115.9 23.4 1.9e-33 115.9 23.4 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily NIF PF03031.18 EMD69498.1 - 6.1e-40 136.5 0.0 1.4e-39 135.4 0.0 1.5 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Glyco_hydro_47 PF01532.20 EMD69499.1 - 6.2e-116 388.0 0.0 8.4e-116 387.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 DUF4679 PF15728.5 EMD69499.1 - 0.7 8.9 4.7 1.1 8.2 4.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4679) Peptidase_M36 PF02128.15 EMD69501.1 - 9.3e-156 518.6 3.6 1.2e-155 518.3 3.6 1.1 1 0 0 1 1 1 1 Fungalysin metallopeptidase (M36) FTP PF07504.13 EMD69501.1 - 1.1e-15 57.2 0.3 2.2e-15 56.2 0.3 1.6 1 0 0 1 1 1 1 Fungalysin/Thermolysin Propeptide Motif Peptidase_M4_C PF02868.15 EMD69501.1 - 0.00013 21.8 0.0 0.00034 20.5 0.0 1.6 1 0 0 1 1 1 1 Thermolysin metallopeptidase, alpha-helical domain ER_lumen_recept PF00810.18 EMD69502.1 - 1.2e-40 139.7 14.5 1.7e-40 139.3 14.5 1.2 1 0 0 1 1 1 1 ER lumen protein retaining receptor Myb_DNA-bind_6 PF13921.6 EMD69503.1 - 0.0094 16.2 7.0 0.041 14.1 0.4 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 EMD69503.1 - 0.16 12.1 3.0 1.7 8.9 0.0 2.4 2 0 0 2 2 2 0 Myb-like DNA-binding domain DUF4800 PF16057.5 EMD69504.1 - 0.089 12.1 0.1 0.12 11.6 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4800) Aldo_ket_red PF00248.21 EMD69505.1 - 2.3e-40 138.6 0.0 7.4e-38 130.4 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family Dev_Cell_Death PF10539.9 EMD69505.1 - 0.099 12.5 0.0 0.21 11.4 0.0 1.5 1 0 0 1 1 1 0 Development and cell death domain ThiJ_like PF17124.5 EMD69506.1 - 1.1e-15 57.9 0.0 1.5e-15 57.4 0.0 1.2 1 0 0 1 1 1 1 ThiJ/PfpI family-like DJ-1_PfpI PF01965.24 EMD69506.1 - 2.9e-14 53.2 0.0 8.4e-14 51.7 0.0 1.7 1 1 0 1 1 1 1 DJ-1/PfpI family GATase_3 PF07685.14 EMD69506.1 - 0.00012 21.8 0.0 0.00016 21.3 0.0 1.2 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain Hydantoinase_B PF02538.14 EMD69507.1 - 2.3e-126 422.3 0.0 6e-126 420.9 0.0 1.7 2 0 0 2 2 2 1 Hydantoinase B/oxoprolinase Hydantoinase_A PF01968.18 EMD69507.1 - 5e-84 282.0 6.6 1.5e-83 280.4 2.4 2.4 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.13 EMD69507.1 - 1.4e-49 168.2 0.9 1.5e-46 158.4 0.1 3.6 3 0 0 3 3 3 2 Hydantoinase/oxoprolinase N-terminal region BcrAD_BadFG PF01869.20 EMD69507.1 - 0.0033 17.0 0.4 0.17 11.3 0.1 2.4 2 0 0 2 2 2 2 BadF/BadG/BcrA/BcrD ATPase family p450 PF00067.22 EMD69510.1 - 4.3e-70 236.8 0.0 5.9e-70 236.3 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 FAD_binding_1 PF00667.20 EMD69510.1 - 3.8e-21 75.7 0.1 8.1e-21 74.6 0.1 1.5 1 1 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 EMD69510.1 - 2.5e-19 69.9 0.0 5.5e-19 68.8 0.0 1.6 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 EMD69510.1 - 2.1e-11 44.4 0.0 1.6e-10 41.6 0.0 2.2 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain Flavodoxin_NdrI PF07972.11 EMD69510.1 - 0.0022 18.2 0.0 0.0048 17.1 0.0 1.6 1 0 0 1 1 1 1 NrdI Flavodoxin like Flavodoxin_5 PF12724.7 EMD69510.1 - 0.0081 16.4 0.0 0.016 15.5 0.0 1.5 1 0 0 1 1 1 1 Flavodoxin domain NAD_binding_6 PF08030.12 EMD69510.1 - 0.034 14.2 0.0 0.072 13.2 0.0 1.6 1 0 0 1 1 1 0 Ferric reductase NAD binding domain Pro_dh PF01619.18 EMD69511.1 - 3.5e-57 194.2 0.3 5.3e-57 193.6 0.3 1.2 1 0 0 1 1 1 1 Proline dehydrogenase TP_methylase PF00590.20 EMD69511.1 - 0.04 13.8 0.4 0.12 12.2 0.0 2.0 3 0 0 3 3 3 0 Tetrapyrrole (Corrin/Porphyrin) Methylases ADH_N PF08240.12 EMD69513.1 - 6.4e-23 80.7 0.4 6.4e-23 80.7 0.4 1.9 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EMD69513.1 - 3.9e-15 56.0 0.2 6.6e-15 55.2 0.2 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EMD69513.1 - 4.2e-06 27.8 0.1 8.2e-06 26.9 0.1 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 EMD69513.1 - 0.0039 16.5 1.4 0.0065 15.8 1.4 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_2 PF03446.15 EMD69513.1 - 0.015 15.4 0.0 0.023 14.9 0.0 1.3 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh_C PF02826.19 EMD69513.1 - 0.14 11.5 0.1 0.23 10.8 0.1 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ApbA PF02558.16 EMD69514.1 - 1.3e-07 31.3 0.0 7.1e-07 29.0 0.0 1.9 2 0 0 2 2 2 1 Ketopantoate reductase PanE/ApbA FAD_binding_3 PF01494.19 EMD69514.1 - 0.037 13.3 0.1 0.058 12.6 0.1 1.3 1 0 0 1 1 1 0 FAD binding domain NAD_binding_8 PF13450.6 EMD69514.1 - 0.039 14.2 0.4 0.086 13.1 0.4 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EMD69514.1 - 0.059 12.6 0.0 0.076 12.2 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Glu_dehyd_C PF16912.5 EMD69514.1 - 0.12 11.9 0.0 0.21 11.1 0.0 1.4 1 0 0 1 1 1 0 Glucose dehydrogenase C-terminus HTH_23 PF13384.6 EMD69515.1 - 1.7e-05 24.5 0.0 2.7e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Homeodomain-like domain HTH_32 PF13565.6 EMD69515.1 - 0.00077 20.0 0.7 0.063 13.9 0.2 2.1 2 0 0 2 2 2 1 Homeodomain-like domain HTH_29 PF13551.6 EMD69515.1 - 0.00082 19.3 0.1 0.0023 17.9 0.1 1.7 1 1 0 1 1 1 1 Winged helix-turn helix HTH_Tnp_ISL3 PF13542.6 EMD69515.1 - 0.0058 16.0 0.0 0.13 11.7 0.0 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain of transposase family ISL3 Sigma70_r4_2 PF08281.12 EMD69515.1 - 0.025 14.3 0.0 0.034 13.8 0.0 1.2 1 0 0 1 1 1 0 Sigma-70, region 4 MerR PF00376.23 EMD69515.1 - 0.065 13.0 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 MerR family regulatory protein MarR_2 PF12802.7 EMD69515.1 - 0.078 12.9 0.0 0.11 12.4 0.0 1.2 1 0 0 1 1 1 0 MarR family HTH_28 PF13518.6 EMD69515.1 - 0.094 12.9 0.2 0.19 11.9 0.2 1.6 1 1 0 1 1 1 0 Helix-turn-helix domain Mito_carr PF00153.27 EMD69516.1 - 1e-19 70.2 4.3 1.1e-14 54.1 0.8 2.1 2 0 0 2 2 2 2 Mitochondrial carrier protein AMP-binding PF00501.28 EMD69517.1 - 2.3e-42 145.1 0.0 3.3e-42 144.6 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EMD69517.1 - 0.0013 19.7 0.0 0.0047 17.9 0.0 2.0 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain ACAS_N PF16177.5 EMD69517.1 - 0.0044 16.9 1.0 0.019 14.9 0.1 2.3 2 0 0 2 2 2 1 Acetyl-coenzyme A synthetase N-terminus HMGL-like PF00682.19 EMD69518.1 - 3.6e-06 26.8 0.0 4.5e-06 26.4 0.0 1.1 1 0 0 1 1 1 1 HMGL-like EnY2 PF10163.9 EMD69518.1 - 0.1 13.0 0.0 0.16 12.3 0.0 1.4 1 0 0 1 1 1 0 Transcription factor e(y)2 Acyl-CoA_dh_1 PF00441.24 EMD69519.1 - 1.8e-30 106.1 0.6 2.3e-30 105.8 0.6 1.1 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_2 PF08028.11 EMD69519.1 - 1.8e-13 50.9 0.2 2.6e-13 50.4 0.2 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 EMD69519.1 - 0.025 14.8 0.0 0.052 13.7 0.0 1.6 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase, middle domain Diphthami_syn_2 PF01902.17 EMD69519.1 - 0.036 13.6 0.0 5.5 6.4 0.0 2.1 2 0 0 2 2 2 0 Diphthamide synthase Fungal_trans_2 PF11951.8 EMD69520.1 - 5.2e-11 42.0 4.4 3.2e-10 39.4 4.4 2.0 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD69520.1 - 9.5e-07 28.8 11.1 1.8e-06 28.0 11.1 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PSI_integrin PF17205.3 EMD69520.1 - 0.00023 20.9 3.6 0.00053 19.7 3.6 1.6 1 0 0 1 1 1 1 Integrin plexin domain DsbC PF11412.8 EMD69520.1 - 0.008 16.2 0.9 0.016 15.3 0.9 1.5 1 0 0 1 1 1 1 Disulphide bond corrector protein DsbC RPA43_OB PF17875.1 EMD69520.1 - 0.62 10.7 4.5 1.4 9.5 3.5 2.0 2 0 0 2 2 2 0 RPA43 OB domain in RNA Pol I PAT1 PF09770.9 EMD69520.1 - 6.4 4.9 20.1 14 3.7 0.1 2.1 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 TFIIA PF03153.13 EMD69520.1 - 8.8 6.2 25.0 1 9.3 18.8 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit HET PF06985.11 EMD69521.1 - 1.5e-10 41.6 11.0 2.7e-08 34.3 2.2 2.9 2 1 1 3 3 3 2 Heterokaryon incompatibility protein (HET) GGACT PF06094.12 EMD69521.1 - 3.7e-09 37.2 0.0 7.4e-09 36.2 0.0 1.5 1 0 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like SesA PF17107.5 EMD69521.1 - 0.00023 21.3 0.6 0.0009 19.4 0.6 2.0 1 0 0 1 1 1 1 N-terminal domain on NACHT_NTPase and P-loop NTPases Helo_like_N PF17111.5 EMD69521.1 - 0.0015 17.9 2.6 0.0026 17.2 2.6 1.3 1 0 0 1 1 1 1 Fungal N-terminal domain of STAND proteins DUF1664 PF07889.12 EMD69521.1 - 3.9 7.5 5.9 13 5.8 1.0 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) WD40 PF00400.32 EMD69522.1 - 1.2e-15 57.6 11.0 0.001 19.8 0.4 6.4 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD69522.1 - 0.00084 19.6 0.1 0.21 11.9 0.0 3.5 4 1 0 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Acyltransferase PF01553.21 EMD69523.1 - 3.1e-17 62.5 0.0 6.5e-17 61.4 0.0 1.6 1 0 0 1 1 1 1 Acyltransferase Adaptin_N PF01602.20 EMD69524.1 - 6.8e-100 335.1 0.0 9.9e-100 334.5 0.0 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EMD69524.1 - 6.7e-16 58.7 0.0 2.5e-14 53.6 0.0 3.0 2 1 1 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EMD69524.1 - 8e-07 29.4 5.1 0.00048 20.5 0.0 4.9 3 2 2 5 5 5 2 HEAT repeats HEAT PF02985.22 EMD69524.1 - 8.8e-06 25.6 1.1 4.3 7.9 0.0 6.5 7 0 0 7 7 7 2 HEAT repeat DUF3922 PF13059.6 EMD69524.1 - 0.16 12.4 0.3 0.56 10.7 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3992) HEAT_EZ PF13513.6 EMD69524.1 - 0.45 11.1 2.2 19 5.9 0.0 4.2 4 0 0 4 4 4 0 HEAT-like repeat Astro_capsid_p PF12226.8 EMD69524.1 - 2.5 7.2 17.6 0.32 10.1 12.9 1.7 2 0 0 2 2 2 0 Turkey astrovirus capsid protein Rho_GDI PF02115.17 EMD69525.1 - 2.4e-61 206.9 0.3 2.6e-61 206.8 0.3 1.0 1 0 0 1 1 1 1 RHO protein GDP dissociation inhibitor KilA-N PF04383.13 EMD69526.1 - 0.0049 16.7 0.0 0.024 14.5 0.0 2.1 2 0 0 2 2 2 1 KilA-N domain Ligase_CoA PF00549.19 EMD69527.1 - 5e-31 107.6 2.0 7.3e-15 55.1 0.4 2.5 2 0 0 2 2 2 2 CoA-ligase CoA_binding PF02629.19 EMD69527.1 - 5.3e-18 65.5 0.4 2.6e-17 63.3 0.4 2.2 1 0 0 1 1 1 1 CoA binding domain Succ_CoA_lig PF13607.6 EMD69527.1 - 5.1e-09 36.0 0.1 6.8e-08 32.4 0.1 2.5 2 0 0 2 2 2 1 Succinyl-CoA ligase like flavodoxin domain GFO_IDH_MocA PF01408.22 EMD69527.1 - 0.1 13.4 0.1 9.5 7.1 0.0 3.0 3 0 0 3 3 3 0 Oxidoreductase family, NAD-binding Rossmann fold ATP-grasp_2 PF08442.10 EMD69527.1 - 0.11 12.0 0.0 0.32 10.5 0.0 1.8 1 0 0 1 1 1 0 ATP-grasp domain Glyco_hydro_15 PF00723.21 EMD69528.1 - 3.9e-68 230.3 0.0 4.6e-68 230.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 Glyco_hydro_11 PF00457.17 EMD69529.1 - 2.4e-78 261.8 21.4 2.8e-78 261.6 21.4 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 11 Aminotran_3 PF00202.21 EMD69530.1 - 1.7e-57 194.9 0.1 1.6e-45 155.5 0.0 2.6 1 1 1 2 2 2 2 Aminotransferase class-III EphA2_TM PF14575.6 EMD69532.1 - 0.025 15.4 0.0 0.047 14.6 0.0 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF5305 PF17231.2 EMD69532.1 - 0.037 13.4 1.1 0.058 12.8 1.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5305) TMEM154 PF15102.6 EMD69532.1 - 0.18 11.7 0.9 0.43 10.5 1.0 1.5 1 1 0 1 1 1 0 TMEM154 protein family Cpn60_TCP1 PF00118.24 EMD69533.1 - 2.2e-153 511.4 17.7 2.5e-153 511.3 17.7 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family ProRS-C_1 PF09180.11 EMD69534.1 - 9e-25 86.7 0.1 2e-24 85.6 0.1 1.6 1 0 0 1 1 1 1 Prolyl-tRNA synthetase, C-terminal HGTP_anticodon PF03129.20 EMD69534.1 - 2.9e-19 69.0 0.1 6.1e-19 68.0 0.1 1.6 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2b PF00587.25 EMD69534.1 - 4.7e-17 62.5 0.0 8.8e-17 61.6 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Proteasom_Rpn13 PF04683.13 EMD69535.1 - 3.2e-26 91.7 0.0 5.8e-26 90.9 0.0 1.4 1 0 0 1 1 1 1 Proteasome complex subunit Rpn13 ubiquitin receptor RPN13_C PF16550.5 EMD69535.1 - 5.6e-08 32.9 0.2 7e-07 29.4 0.2 2.3 1 1 0 1 1 1 1 UCH-binding domain UCR_14kD PF02271.16 EMD69535.1 - 0.15 12.0 0.1 0.29 11.1 0.1 1.4 1 0 0 1 1 1 0 Ubiquinol-cytochrome C reductase complex 14kD subunit Ribosomal_L6e PF01159.19 EMD69536.1 - 1.5e-38 131.8 0.1 1.5e-38 131.8 0.1 1.6 2 0 0 2 2 2 1 Ribosomal protein L6e GNAT_acetyltr_2 PF13718.6 EMD69536.1 - 0.022 14.1 0.1 0.035 13.5 0.1 1.3 1 0 0 1 1 1 0 GNAT acetyltransferase 2 KOW PF00467.29 EMD69536.1 - 0.048 13.6 0.6 0.16 12.0 0.3 2.0 2 0 0 2 2 2 0 KOW motif DUF3544 PF12064.8 EMD69536.1 - 0.055 13.8 0.0 0.073 13.4 0.0 1.4 1 1 0 1 1 1 0 Protein kinase C-binding protein 1 FA_hydroxylase PF04116.13 EMD69537.1 - 7.4e-15 55.5 7.8 7.4e-15 55.5 7.8 1.7 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily ADH_zinc_N PF00107.26 EMD69538.1 - 1.6e-29 102.5 0.0 2.7e-29 101.8 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EMD69538.1 - 8.7e-16 59.2 0.0 1.6e-15 58.3 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EMD69538.1 - 5.7e-08 32.6 0.0 1.9e-07 30.9 0.0 1.8 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain adh_short PF00106.25 EMD69538.1 - 0.00072 19.1 0.0 0.0012 18.4 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase ADH_N_2 PF16884.5 EMD69538.1 - 0.00088 19.2 0.0 0.0016 18.3 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase TrkA_N PF02254.18 EMD69538.1 - 0.11 12.8 0.1 0.24 11.7 0.1 1.5 1 0 0 1 1 1 0 TrkA-N domain DUF938 PF06080.12 EMD69538.1 - 0.2 11.4 0.0 0.34 10.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF938) HTH_AsnC-type PF13404.6 EMD69539.1 - 0.011 15.6 0.0 1.8 8.5 0.0 2.4 2 0 0 2 2 2 0 AsnC-type helix-turn-helix domain DTHCT PF08070.11 EMD69539.1 - 4 8.2 17.3 1.2 9.9 13.5 2.0 2 1 0 2 2 2 0 DTHCT (NUC029) region Exo84_C PF16528.5 EMD69540.1 - 2.1e-71 240.0 1.3 2.1e-71 240.0 1.3 1.9 2 0 0 2 2 2 1 Exocyst component 84 C-terminal Vps51 PF08700.11 EMD69540.1 - 1.3e-15 57.2 4.2 1.3e-15 57.2 4.2 2.1 2 0 0 2 2 2 1 Vps51/Vps67 COG2 PF06148.11 EMD69540.1 - 0.015 15.4 1.0 0.015 15.4 1.0 2.1 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 BST2 PF16716.5 EMD69540.1 - 0.13 12.8 5.3 0.56 10.8 1.5 2.7 2 0 0 2 2 2 0 Bone marrow stromal antigen 2 Bacteriocin_IIc PF10439.9 EMD69540.1 - 0.21 11.7 0.0 0.35 11.0 0.0 1.3 1 0 0 1 1 1 0 Bacteriocin class II with double-glycine leader peptide Exonuc_VII_L PF02601.15 EMD69540.1 - 9.7 5.7 11.2 3 7.3 2.0 2.2 2 0 0 2 2 2 0 Exonuclease VII, large subunit MAS20 PF02064.15 EMD69541.1 - 1.3e-49 167.6 1.4 1.5e-49 167.4 1.4 1.0 1 0 0 1 1 1 1 MAS20 protein import receptor HPTransfase PF10090.9 EMD69541.1 - 0.0062 16.3 0.2 0.014 15.2 0.2 1.5 1 0 0 1 1 1 1 Histidine phosphotransferase C-terminal domain DUF2681 PF10883.8 EMD69541.1 - 0.057 13.8 0.4 0.088 13.2 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) LapA_dom PF06305.11 EMD69541.1 - 0.18 11.7 0.0 0.38 10.6 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain AP-5_subunit_s1 PF15001.6 EMD69541.1 - 0.29 11.1 1.3 0.37 10.8 1.3 1.1 1 0 0 1 1 1 0 AP-5 complex subunit sigma-1 Nucleolin_bd PF16725.5 EMD69541.1 - 1.5 8.5 5.1 0.54 10.0 2.2 1.7 2 0 0 2 2 2 0 Nucleolin binding domain Ras PF00071.22 EMD69542.1 - 1.8e-59 200.0 0.5 2.3e-59 199.6 0.5 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMD69542.1 - 4.7e-37 126.9 0.2 9e-37 126.0 0.2 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMD69542.1 - 9.7e-18 64.2 0.3 1.2e-17 63.9 0.3 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EMD69542.1 - 2.6e-06 27.1 0.2 3.2e-05 23.5 0.1 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 EMD69542.1 - 5e-06 26.1 0.0 6.6e-06 25.7 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 EMD69542.1 - 1.7e-05 24.8 0.1 3.2e-05 24.0 0.1 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EMD69542.1 - 2.6e-05 23.7 0.2 3.4e-05 23.3 0.2 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 EMD69542.1 - 2.7e-05 24.2 0.6 0.014 15.3 0.3 2.3 2 1 0 2 2 2 2 RsgA GTPase AAA_7 PF12775.7 EMD69542.1 - 0.093 12.2 0.0 0.16 11.4 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_28 PF13521.6 EMD69542.1 - 0.12 12.6 0.0 11 6.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain Nop53 PF07767.11 EMD69543.1 - 7.3e-104 348.3 43.3 8.8e-104 348.0 43.3 1.1 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) MFS_1 PF07690.16 EMD69544.1 - 5.8e-33 114.3 15.4 8.7e-33 113.7 13.7 1.8 2 0 0 2 2 2 1 Major Facilitator Superfamily Syja_N PF02383.18 EMD69545.1 - 1e-80 271.4 0.1 2e-80 270.5 0.1 1.5 1 0 0 1 1 1 1 SacI homology domain Hexokinase_2 PF03727.16 EMD69546.1 - 1.5e-54 185.0 0.0 1.9e-54 184.6 0.0 1.1 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 EMD69546.1 - 4e-53 180.3 0.0 6.2e-53 179.7 0.0 1.2 1 0 0 1 1 1 1 Hexokinase GILT PF03227.16 EMD69547.1 - 1.3e-16 60.8 0.0 2.2e-16 60.0 0.0 1.4 1 0 0 1 1 1 1 Gamma interferon inducible lysosomal thiol reductase (GILT) Ntox16 PF15523.6 EMD69547.1 - 0.01 16.1 0.1 4.4 7.6 0.0 2.4 2 0 0 2 2 2 0 Novel toxin 16 MDFI PF15316.6 EMD69547.1 - 0.21 11.7 0.1 0.21 11.7 0.1 2.4 3 0 0 3 3 3 0 MyoD family inhibitor DUF1681 PF07933.14 EMD69548.1 - 7.7e-55 184.7 0.0 1.1e-54 184.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1681) Tyrosinase PF00264.20 EMD69549.1 - 1.7e-49 169.1 3.6 2.7e-49 168.5 3.6 1.3 1 0 0 1 1 1 1 Common central domain of tyrosinase zf-RING_4 PF14570.6 EMD69549.1 - 3.8 7.4 5.0 0.57 10.0 0.9 1.8 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain HAD PF12710.7 EMD69551.1 - 2.1e-22 80.5 0.0 3.1e-22 79.9 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.12 EMD69551.1 - 0.00078 18.9 0.1 0.84 9.0 0.0 2.1 2 0 0 2 2 2 2 Putative Phosphatase UMPH-1 PF05822.12 EMD69551.1 - 0.007 15.9 0.0 0.026 14.0 0.0 1.9 2 1 0 2 2 2 1 Pyrimidine 5'-nucleotidase (UMPH-1) She9_MDM33 PF05546.11 EMD69552.1 - 1.8e-57 194.4 9.1 3.2e-57 193.5 9.1 1.4 1 0 0 1 1 1 1 She9 / Mdm33 family DUF441 PF04284.13 EMD69552.1 - 0.074 13.1 1.4 0.93 9.5 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF441) DUF2564 PF10819.8 EMD69552.1 - 1.6 9.2 16.2 0.094 13.1 1.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2564) Exonuc_VII_L PF02601.15 EMD69552.1 - 4.9 6.6 14.8 17 4.8 12.7 2.7 2 1 0 2 2 2 0 Exonuclease VII, large subunit RNase_P_Rpp14 PF01900.19 EMD69553.1 - 2.8e-36 123.9 0.0 4.1e-36 123.3 0.0 1.3 1 0 0 1 1 1 1 Rpp14/Pop5 family Synaptobrevin PF00957.21 EMD69554.1 - 4.7e-31 106.4 0.1 6.7e-31 105.9 0.1 1.2 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 EMD69554.1 - 2.5e-21 75.5 0.1 4.6e-21 74.6 0.0 1.5 2 0 0 2 2 2 1 Regulated-SNARE-like domain TRIQK PF15168.6 EMD69554.1 - 0.13 12.2 0.3 0.31 11.0 0.1 1.6 2 0 0 2 2 2 0 Triple QxxK/R motif-containing protein family CPSase_L_D2 PF02786.17 EMD69555.1 - 3.6e-113 376.3 0.5 2e-82 275.8 0.0 2.3 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain GATase PF00117.28 EMD69555.1 - 2.6e-47 161.1 0.0 6.1e-47 159.9 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase class-I CPSase_sm_chain PF00988.22 EMD69555.1 - 1.1e-46 157.8 0.0 2.4e-46 156.7 0.0 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain OTCace_N PF02729.21 EMD69555.1 - 1.7e-44 151.4 0.0 3.6e-44 150.4 0.0 1.6 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain CPSase_L_D3 PF02787.19 EMD69555.1 - 1e-40 138.9 0.1 2.9e-40 137.4 0.1 1.8 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain OTCace PF00185.24 EMD69555.1 - 6.4e-34 117.3 0.0 1.7e-33 115.9 0.0 1.8 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain MGS PF02142.22 EMD69555.1 - 1.2e-19 70.3 0.0 6.1e-19 68.0 0.0 2.4 1 0 0 1 1 1 1 MGS-like domain Dala_Dala_lig_C PF07478.13 EMD69555.1 - 3.7e-17 62.5 0.6 1.1e-08 34.8 0.1 2.6 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 EMD69555.1 - 5.1e-15 55.5 0.2 7.1e-07 29.0 0.0 3.1 3 0 0 3 3 3 2 ATP-grasp domain ATPgrasp_Ter PF15632.6 EMD69555.1 - 1.4e-09 37.8 0.1 4.3e-05 23.3 0.0 2.9 2 1 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon Peptidase_C26 PF07722.13 EMD69555.1 - 2.4e-06 27.5 0.2 0.00069 19.4 0.2 2.6 1 1 0 1 1 1 1 Peptidase C26 ATP-grasp_3 PF02655.14 EMD69555.1 - 7.1e-06 26.2 0.7 0.023 14.7 0.1 2.9 3 0 0 3 3 3 2 ATP-grasp domain DJ-1_PfpI PF01965.24 EMD69555.1 - 5.2e-05 23.1 0.0 0.0019 18.0 0.0 2.8 2 0 0 2 2 2 1 DJ-1/PfpI family GARS_A PF01071.19 EMD69555.1 - 0.0013 18.5 0.2 2.6 7.8 0.0 2.9 3 0 0 3 3 3 2 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain RimK PF08443.11 EMD69555.1 - 0.011 15.4 0.0 6.3 6.3 0.0 2.6 2 0 0 2 2 2 0 RimK-like ATP-grasp domain Ion_trans PF00520.31 EMD69557.1 - 3.6e-09 36.2 24.5 8e-09 35.1 24.5 1.6 1 0 0 1 1 1 1 Ion transport protein Rad60-SLD PF11976.8 EMD69559.1 - 9.8e-18 63.8 0.2 1.2e-17 63.4 0.2 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 EMD69559.1 - 5.9e-10 38.8 0.1 7.2e-10 38.5 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin family MTCP1 PF08991.10 EMD69560.1 - 6.7e-28 96.7 11.2 7.9e-28 96.5 11.2 1.1 1 0 0 1 1 1 1 Mature-T-Cell Proliferation I type CHCH PF06747.13 EMD69560.1 - 0.0027 17.8 6.7 0.0027 17.8 6.7 1.6 2 0 0 2 2 2 1 CHCH domain Cmc1 PF08583.10 EMD69560.1 - 0.018 15.0 2.8 0.018 15.0 2.8 1.8 1 1 1 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like Nup84_Nup100 PF04121.13 EMD69561.1 - 2.6e-136 455.7 5.3 3.5e-136 455.2 5.3 1.2 1 0 0 1 1 1 1 Nuclear pore protein 84 / 107 EF-hand_like PF09279.11 EMD69561.1 - 0.068 13.7 0.3 0.36 11.3 0.1 2.4 2 0 0 2 2 2 0 Phosphoinositide-specific phospholipase C, efhand-like DUF1295 PF06966.12 EMD69562.1 - 3.8e-30 105.1 0.1 5.6e-30 104.6 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) Steroid_dh PF02544.16 EMD69562.1 - 0.00075 19.5 0.0 0.0016 18.5 0.0 1.5 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase ICMT PF04140.14 EMD69562.1 - 0.036 14.5 0.0 0.08 13.4 0.0 1.5 1 0 0 1 1 1 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 EMD69562.1 - 0.07 13.5 0.0 0.2 12.0 0.0 1.8 1 0 0 1 1 1 0 Phospholipid methyltransferase Exo_endo_phos PF03372.23 EMD69563.1 - 0.051 13.1 0.1 0.11 12.0 0.1 1.6 1 1 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family Ribonuc_L-PSP PF01042.21 EMD69564.1 - 1.9e-11 44.0 0.0 4.7e-11 42.7 0.0 1.6 1 1 0 1 1 1 1 Endoribonuclease L-PSP Arginase PF00491.21 EMD69565.1 - 3e-80 269.7 0.7 3.6e-80 269.5 0.7 1.0 1 0 0 1 1 1 1 Arginase family UPF0489 PF12640.7 EMD69565.1 - 0.047 13.9 0.7 0.074 13.3 0.7 1.2 1 0 0 1 1 1 0 UPF0489 domain Cyt-b5 PF00173.28 EMD69566.1 - 0.0025 17.9 0.0 0.0028 17.7 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Cathelicidins PF00666.17 EMD69567.1 - 0.045 14.1 0.6 0.053 13.8 0.6 1.1 1 0 0 1 1 1 0 Cathelicidin RRM_1 PF00076.22 EMD69568.1 - 9.4e-65 214.4 1.2 2.1e-20 72.3 0.1 5.8 5 0 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PHM7_cyt PF14703.6 EMD69568.1 - 2.9e-06 27.6 7.2 0.34 11.1 0.0 6.2 4 3 2 6 6 6 2 Cytosolic domain of 10TM putative phosphate transporter RRM_5 PF13893.6 EMD69568.1 - 1.7e-05 24.4 0.0 0.035 13.7 0.0 2.6 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EMD69568.1 - 4.3e-05 23.6 0.8 1.1 9.5 0.0 4.3 4 1 0 4 4 4 2 RNA recognition motif Limkain-b1 PF11608.8 EMD69568.1 - 0.0044 17.1 0.5 0.25 11.4 0.3 3.6 4 0 0 4 4 4 1 Limkain b1 DbpA PF03880.15 EMD69568.1 - 0.0051 16.8 1.9 3.1 7.8 0.1 3.3 3 0 0 3 3 3 2 DbpA RNA binding domain RRM_occluded PF16842.5 EMD69568.1 - 0.0054 16.6 0.0 3.5 7.6 0.0 3.5 3 0 0 3 3 3 1 Occluded RNA-recognition motif SET_assoc PF11767.8 EMD69568.1 - 0.14 11.8 0.0 3.2 7.5 0.0 2.9 3 0 0 3 3 3 0 Histone lysine methyltransferase SET associated Nop14 PF04147.12 EMD69568.1 - 4 5.5 42.1 0.65 8.1 20.5 3.2 3 0 0 3 3 3 0 Nop14-like family MFS_1 PF07690.16 EMD69569.1 - 2.4e-25 89.2 41.1 1.8e-17 63.3 19.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EMD69569.1 - 1.2e-15 57.4 20.6 1.4e-14 53.9 20.6 2.3 1 1 0 1 1 1 1 Sugar (and other) transporter TRI12 PF06609.13 EMD69569.1 - 0.0057 15.1 1.8 0.0098 14.3 1.8 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) ABC_tran PF00005.27 EMD69571.1 - 1.8e-20 73.9 0.0 2.5e-10 41.0 0.0 2.8 3 1 0 3 3 3 2 ABC transporter AAA_21 PF13304.6 EMD69571.1 - 6.1e-07 29.5 0.5 0.081 12.7 0.0 3.1 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system SbcCD_C PF13558.6 EMD69571.1 - 0.00013 22.1 0.0 0.0014 18.8 0.1 2.3 2 0 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_23 PF13476.6 EMD69571.1 - 0.11 12.9 0.4 0.11 12.9 0.4 1.7 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 EMD69571.1 - 0.13 12.1 0.1 0.25 11.1 0.1 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Inhibitor_I42 PF09394.10 EMD69571.1 - 0.16 12.4 0.3 2.7 8.5 0.0 2.9 4 0 0 4 4 4 0 Chagasin family peptidase inhibitor I42 DUF3584 PF12128.8 EMD69571.1 - 0.22 9.0 0.4 0.36 8.3 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) AAA_13 PF13166.6 EMD69571.1 - 0.23 10.0 0.0 0.42 9.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain Cupin_8 PF13621.6 EMD69572.1 - 2.3e-36 125.8 0.0 4.9e-36 124.7 0.0 1.5 1 0 0 1 1 1 1 Cupin-like domain LCM PF04072.14 EMD69572.1 - 7.3e-21 75.0 0.0 1.3e-20 74.1 0.0 1.4 1 0 0 1 1 1 1 Leucine carboxyl methyltransferase Kelch_4 PF13418.6 EMD69572.1 - 6.8e-18 64.4 8.2 2.4e-07 30.7 0.0 6.3 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_5 PF13854.6 EMD69572.1 - 1.3e-09 37.9 0.1 0.15 12.1 0.0 4.9 4 0 0 4 4 4 3 Kelch motif Kelch_3 PF13415.6 EMD69572.1 - 1.7e-08 34.5 9.4 0.00059 20.1 0.0 5.5 5 0 0 5 5 5 2 Galactose oxidase, central domain Cupin_4 PF08007.12 EMD69572.1 - 6.6e-05 22.5 0.0 0.00015 21.4 0.0 1.5 1 0 0 1 1 1 1 Cupin superfamily protein ANAPC4_WD40 PF12894.7 EMD69573.1 - 3e-05 24.3 0.0 2 8.8 0.0 4.8 3 2 2 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EMD69573.1 - 0.0022 18.8 0.0 0.038 14.9 0.0 2.8 3 0 0 3 3 3 1 WD domain, G-beta repeat BBS2_N PF14781.6 EMD69573.1 - 0.006 16.5 0.4 0.7 9.8 0.0 3.4 4 1 0 4 4 4 1 Ciliary BBSome complex subunit 2, N-terminal Hira PF07569.11 EMD69573.1 - 0.093 12.4 0.0 3.4 7.3 0.0 2.4 2 0 0 2 2 2 0 TUP1-like enhancer of split Ge1_WD40 PF16529.5 EMD69573.1 - 0.26 10.2 0.2 0.76 8.7 0.0 1.8 3 0 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein PI31_Prot_N PF11566.8 EMD69574.1 - 5.6e-53 179.1 0.0 7e-53 178.8 0.0 1.1 1 0 0 1 1 1 1 PI31 proteasome regulator N-terminal PI31_Prot_C PF08577.11 EMD69574.1 - 8.3e-17 62.1 16.8 8.3e-17 62.1 16.8 3.2 3 1 0 3 3 3 1 PI31 proteasome regulator zf-C2H2 PF00096.26 EMD69575.1 - 5.5e-10 39.2 11.0 0.0074 16.7 1.0 4.4 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMD69575.1 - 2.4e-08 34.1 8.1 0.051 14.4 0.6 4.0 4 0 0 4 4 4 3 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EMD69575.1 - 7.3e-07 29.3 10.4 0.016 15.6 0.8 3.7 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2_8 PF15909.5 EMD69575.1 - 0.0047 17.2 3.6 0.0096 16.2 3.6 1.5 1 0 0 1 1 1 1 C2H2-type zinc ribbon Mis14 PF08641.12 EMD69576.1 - 0.18 12.1 0.1 0.35 11.2 0.1 1.4 1 0 0 1 1 1 0 Kinetochore protein Mis14 like Asn_synthase PF00733.21 EMD69577.1 - 3.3e-14 53.3 0.5 5.1e-08 33.0 1.0 3.2 2 1 0 2 2 2 2 Asparagine synthase GATase_7 PF13537.6 EMD69577.1 - 9.5e-05 22.3 0.0 0.00048 20.0 0.0 2.1 1 1 0 1 1 1 1 Glutamine amidotransferase domain DUF3700 PF12481.8 EMD69577.1 - 0.03 13.8 0.0 0.061 12.8 0.0 1.4 1 0 0 1 1 1 0 Aluminium induced protein GATase_6 PF13522.6 EMD69577.1 - 0.036 14.3 0.0 0.13 12.4 0.0 2.0 1 1 0 1 1 1 0 Glutamine amidotransferase domain VPS9 PF02204.18 EMD69578.1 - 8.2e-28 96.7 0.0 1.4e-27 95.9 0.0 1.4 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain DUF5601 PF18151.1 EMD69578.1 - 6.2e-15 55.3 0.1 1.7e-14 53.8 0.1 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF5601) CUE PF02845.16 EMD69578.1 - 6e-10 38.6 0.1 9.3e-09 34.8 0.0 2.3 2 0 0 2 2 2 1 CUE domain zf-C2H2 PF00096.26 EMD69579.1 - 2.4e-15 56.0 61.8 0.086 13.3 0.3 11.9 12 0 0 12 12 12 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMD69579.1 - 8.3e-11 41.8 61.6 0.031 15.1 0.1 11.4 11 0 0 11 11 11 7 C2H2-type zinc finger zf-met PF12874.7 EMD69579.1 - 2.3e-08 34.2 41.5 0.012 16.0 0.1 9.6 10 0 0 10 10 10 5 Zinc-finger of C2H2 type zf-H2C2_5 PF13909.6 EMD69579.1 - 0.00015 21.4 23.5 0.00061 19.5 5.3 5.9 6 0 0 6 6 6 1 C2H2-type zinc-finger domain zf-C2H2_jaz PF12171.8 EMD69579.1 - 0.00056 20.1 2.4 0.0021 18.3 0.6 8.8 11 0 0 11 11 11 4 Zinc-finger double-stranded RNA-binding RepB-RCR_reg PF10723.9 EMD69579.1 - 0.2 11.6 0.4 38 4.3 0.0 3.1 2 1 1 3 3 3 0 Replication regulatory protein RepB zf-C2H2_2 PF12756.7 EMD69579.1 - 0.28 11.5 45.1 1.2 9.5 4.9 6.6 2 1 5 7 7 7 0 C2H2 type zinc-finger (2 copies) Aldedh PF00171.22 EMD69581.1 - 2.7e-152 507.5 0.2 3.3e-152 507.2 0.2 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 EMD69581.1 - 0.00014 21.1 0.0 0.00021 20.5 0.0 1.2 1 0 0 1 1 1 1 Acyl-CoA reductase (LuxC) DUF1487 PF07368.11 EMD69581.1 - 0.012 15.1 0.1 2.6 7.5 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1487) Ank_2 PF12796.7 EMD69582.1 - 9.2e-12 45.4 0.0 3.3e-10 40.4 0.0 2.8 2 1 1 3 3 3 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMD69582.1 - 5.2e-10 39.7 0.2 0.002 18.7 0.0 4.4 4 1 1 5 5 5 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 EMD69582.1 - 1.1e-07 31.9 0.0 1.1e-06 28.8 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMD69582.1 - 3.7e-06 26.9 0.1 0.0044 17.4 0.0 4.1 5 0 0 5 5 5 1 Ankyrin repeat Ank PF00023.30 EMD69582.1 - 7.8e-06 26.1 0.3 0.0087 16.5 0.0 4.3 5 0 0 5 5 5 1 Ankyrin repeat SesA PF17107.5 EMD69582.1 - 0.0015 18.7 0.3 0.0041 17.3 0.0 1.8 2 0 0 2 2 2 1 N-terminal domain on NACHT_NTPase and P-loop NTPases DUF2384 PF09722.10 EMD69582.1 - 0.044 13.8 0.1 1.9 8.6 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2384) Glyoxalase_6 PF18029.1 EMD69582.1 - 0.14 13.0 0.0 23 5.8 0.0 2.5 2 0 0 2 2 2 0 Glyoxalase-like domain eRF1_3 PF03465.15 EMD69582.1 - 0.2 12.1 0.0 0.51 10.8 0.0 1.6 1 0 0 1 1 1 0 eRF1 domain 3 Glyco_hydro_67M PF07488.12 EMD69583.1 - 3.4e-140 466.7 0.1 5.4e-140 466.1 0.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 67 middle domain Glyco_hydro_67C PF07477.12 EMD69583.1 - 4.6e-90 301.0 1.8 9.2e-90 300.1 1.8 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 67 C-terminus Glyco_hydro_67N PF03648.14 EMD69583.1 - 6.5e-28 97.5 0.1 1.3e-27 96.5 0.1 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 67 N-terminus Glyco_hydro_20b PF02838.15 EMD69583.1 - 0.00017 22.3 0.2 0.00053 20.8 0.2 1.8 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, domain 2 NAGLU_N PF12971.7 EMD69583.1 - 0.14 12.0 0.0 0.37 10.6 0.0 1.8 1 0 0 1 1 1 0 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain Peptidase_S9 PF00326.21 EMD69584.1 - 1.4e-48 165.2 0.6 2.4e-48 164.4 0.6 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family DUF2920 PF11144.8 EMD69584.1 - 0.2 10.8 0.0 0.32 10.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2920) PTR2 PF00854.21 EMD69585.1 - 1.5e-79 267.7 9.5 1.9e-79 267.4 9.5 1.1 1 0 0 1 1 1 1 POT family Bac_rhodopsin PF01036.18 EMD69585.1 - 0.9 9.1 9.4 0.26 10.8 0.4 2.9 3 0 0 3 3 3 0 Bacteriorhodopsin-like protein F-box PF00646.33 EMD69586.1 - 0.00088 19.1 0.1 0.0024 17.7 0.1 1.7 1 0 0 1 1 1 1 F-box domain Zn_clus PF00172.18 EMD69588.1 - 1e-09 38.3 9.9 2e-09 37.4 9.9 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EMD69588.1 - 0.027 13.5 0.0 0.049 12.6 0.0 1.4 1 0 0 1 1 1 0 Fungal specific transcription factor domain F-box PF00646.33 EMD69590.1 - 0.021 14.7 0.4 0.098 12.6 0.1 2.2 2 0 0 2 2 2 0 F-box domain F-box-like PF12937.7 EMD69590.1 - 1.5 8.7 5.1 0.7 9.8 0.5 2.7 3 0 0 3 3 3 0 F-box-like IPK PF03770.16 EMD69591.1 - 1.1e-59 201.7 0.0 1.3e-59 201.4 0.0 1.0 1 0 0 1 1 1 1 Inositol polyphosphate kinase Arb1 PF09692.10 EMD69592.1 - 4.1e-130 434.6 0.0 5.5e-130 434.1 0.0 1.1 1 0 0 1 1 1 1 Argonaute siRNA chaperone (ARC) complex subunit Arb1 La PF05383.17 EMD69592.1 - 5.3e-15 55.2 0.0 1.5e-14 53.7 0.0 1.8 1 0 0 1 1 1 1 La domain RTA1 PF04479.13 EMD69593.1 - 2e-41 141.9 4.1 2e-41 141.9 4.1 1.8 2 1 0 2 2 2 1 RTA1 like protein UPF0086 PF01868.16 EMD69594.1 - 3.7e-14 52.4 0.2 7e-14 51.5 0.2 1.4 1 0 0 1 1 1 1 Domain of unknown function UPF0086 Ribosomal_L6 PF00347.23 EMD69595.1 - 6.6e-26 90.8 4.8 5.9e-13 49.3 1.4 2.1 2 0 0 2 2 2 2 Ribosomal protein L6 Aldo_ket_red PF00248.21 EMD69596.1 - 2.6e-68 230.4 0.0 3.2e-68 230.1 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family F-box-like_2 PF13013.6 EMD69598.1 - 0.055 13.4 0.0 0.17 11.8 0.0 1.8 1 0 0 1 1 1 0 F-box-like domain CLP1_P PF16575.5 EMD69599.1 - 1.1e-35 123.2 0.0 2.3e-35 122.1 0.0 1.5 1 1 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop CLP1_N PF16573.5 EMD69599.1 - 1.7e-33 114.7 0.0 2.9e-33 114.0 0.0 1.4 1 0 0 1 1 1 1 N-terminal beta-sandwich domain of polyadenylation factor Clp1 PF06807.14 EMD69599.1 - 2.6e-24 85.9 0.0 4.4e-24 85.2 0.0 1.4 1 0 0 1 1 1 1 Pre-mRNA cleavage complex II protein Clp1 ATP_bind_1 PF03029.17 EMD69599.1 - 6.7e-06 26.1 0.0 1.2e-05 25.2 0.0 1.4 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein MMR_HSR1 PF01926.23 EMD69599.1 - 0.0013 18.8 0.0 0.0046 17.0 0.0 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase SRPRB PF09439.10 EMD69599.1 - 0.004 16.6 0.1 0.014 14.8 0.0 1.9 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit AAA_16 PF13191.6 EMD69599.1 - 0.016 15.6 0.0 0.031 14.7 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_7 PF12775.7 EMD69599.1 - 0.021 14.3 0.0 0.039 13.5 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region Roc PF08477.13 EMD69599.1 - 0.03 14.5 0.0 0.061 13.5 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_24 PF13479.6 EMD69599.1 - 0.037 13.8 0.0 0.061 13.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_35 PF14516.6 EMD69599.1 - 0.052 12.4 0.0 0.08 11.8 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain TniB PF05621.11 EMD69599.1 - 0.1 12.0 0.0 0.3 10.5 0.0 1.7 2 0 0 2 2 2 0 Bacterial TniB protein ATPase_2 PF01637.18 EMD69599.1 - 0.13 12.2 0.0 0.27 11.1 0.0 1.5 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea ABC_tran PF00005.27 EMD69599.1 - 0.13 12.8 0.0 0.3 11.6 0.0 1.6 1 0 0 1 1 1 0 ABC transporter Terminase_GpA PF05876.12 EMD69599.1 - 0.16 10.5 0.0 0.28 9.7 0.0 1.3 1 0 0 1 1 1 0 Phage terminase large subunit (GpA) PduV-EutP PF10662.9 EMD69599.1 - 0.19 11.5 0.0 0.32 10.7 0.0 1.3 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Glyco_hydro_125 PF06824.11 EMD69600.1 - 1e-180 601.1 0.0 1.2e-180 600.9 0.0 1.0 1 0 0 1 1 1 1 Metal-independent alpha-mannosidase (GH125) Abhydrolase_6 PF12697.7 EMD69601.1 - 4.5e-09 37.2 2.6 2.3e-08 34.9 0.9 2.6 2 1 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EMD69601.1 - 9.8e-07 28.7 0.0 4.6e-06 26.5 0.0 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EMD69601.1 - 0.00063 19.1 0.3 0.13 11.5 0.1 2.7 1 1 0 2 2 2 2 Serine aminopeptidase, S33 ATG16 PF08614.11 EMD69601.1 - 0.011 16.0 6.9 0.011 16.0 6.9 3.0 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) RhoGEF PF00621.20 EMD69604.1 - 3.4e-24 86.1 0.0 9.3e-24 84.7 0.0 1.7 1 0 0 1 1 1 1 RhoGEF domain Nod1 PF17114.5 EMD69604.1 - 4.7e-05 23.6 0.0 0.00012 22.3 0.0 1.6 1 0 0 1 1 1 1 Gef2-related medial cortical node protein Nod1 DUF3507 PF12015.8 EMD69604.1 - 0.0044 16.7 0.0 0.0084 15.8 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3507) DUF1640 PF07798.11 EMD69604.1 - 1.1 9.3 11.2 0.41 10.7 5.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1640) FapA PF03961.13 EMD69604.1 - 3.8 6.0 6.0 1.4 7.4 2.4 2.0 1 1 1 2 2 2 0 Flagellar Assembly Protein A DUF4140 PF13600.6 EMD69604.1 - 8.5 6.9 7.6 30 5.1 2.5 3.3 3 0 0 3 3 3 0 N-terminal domain of unknown function (DUF4140) Dcc1 PF09724.9 EMD69605.1 - 1.2e-34 120.2 0.0 1.4e-34 119.9 0.0 1.0 1 0 0 1 1 1 1 Sister chromatid cohesion protein Dcc1 Hemerythrin PF01814.23 EMD69606.1 - 6.4e-13 49.5 2.1 8.5e-13 49.1 2.1 1.1 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain Activator-TraM PF11657.8 EMD69606.1 - 0.069 13.0 0.1 0.1 12.4 0.1 1.2 1 0 0 1 1 1 0 Transcriptional activator TraM DUF3112 PF11309.8 EMD69607.1 - 2.7e-05 23.7 0.0 2.7e-05 23.7 0.0 3.2 3 1 1 4 4 4 2 Protein of unknown function (DUF3112) Phage_holin_4_1 PF05105.12 EMD69607.1 - 1.8 8.7 7.5 0.22 11.6 1.8 2.1 2 1 0 2 2 2 0 Bacteriophage holin family Tyrosinase PF00264.20 EMD69610.1 - 3.5e-49 168.1 0.1 5.5e-49 167.4 0.1 1.3 1 0 0 1 1 1 1 Common central domain of tyrosinase DUF1100 PF06500.11 EMD69610.1 - 0.13 11.0 0.0 0.19 10.5 0.0 1.1 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1100) DUF4202 PF13875.6 EMD69611.1 - 7.5e-83 277.0 0.1 8.4e-83 276.8 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4202) Fungal_trans PF04082.18 EMD69612.1 - 5.7e-14 51.8 2.6 9.6e-14 51.0 2.6 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD69612.1 - 7e-08 32.5 9.9 1.1e-07 31.8 9.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 EMD69613.1 - 1e-18 67.3 0.0 2e-18 66.4 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD69613.1 - 3e-07 30.4 14.2 4.9e-07 29.8 14.2 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain U3_snoRNA_assoc PF08297.11 EMD69613.1 - 0.018 15.7 0.0 0.046 14.4 0.0 1.7 1 0 0 1 1 1 0 U3 snoRNA associated A2M PF00207.22 EMD69614.1 - 0.081 12.8 0.0 1.3 8.9 0.0 2.3 1 1 1 2 2 2 0 Alpha-2-macroglobulin family Sulfate_transp PF00916.20 EMD69616.1 - 2.2e-101 339.4 14.4 3.3e-101 338.8 14.4 1.2 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 EMD69616.1 - 3.9e-07 29.7 0.0 7.6e-07 28.8 0.0 1.4 1 0 0 1 1 1 1 STAS domain TRI12 PF06609.13 EMD69619.1 - 4.6e-25 88.1 28.8 6e-25 87.7 28.8 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_1 PF07690.16 EMD69619.1 - 1.1e-24 87.1 45.0 2e-24 86.2 45.0 1.6 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_2 PF13347.6 EMD69619.1 - 8.3e-05 21.3 3.4 8.3e-05 21.3 3.4 3.7 1 1 1 3 3 3 2 MFS/sugar transport protein DUF3727 PF12527.8 EMD69620.1 - 0.4 10.9 5.9 2.1 8.6 5.9 2.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3727) adh_short PF00106.25 EMD69621.1 - 1.9e-53 180.9 0.0 2.5e-53 180.5 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD69621.1 - 8.1e-36 123.7 0.0 9.6e-36 123.5 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD69621.1 - 6.2e-12 45.8 0.0 8.7e-12 45.3 0.0 1.2 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EMD69621.1 - 0.0023 17.1 0.0 0.0097 15.1 0.0 1.9 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein Sacchrp_dh_NADP PF03435.18 EMD69621.1 - 0.0053 17.0 0.1 0.0096 16.2 0.1 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain DUF1776 PF08643.10 EMD69621.1 - 0.056 12.8 0.0 0.085 12.2 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) THF_DHG_CYH_C PF02882.19 EMD69621.1 - 0.061 12.6 0.1 1.9 7.8 0.0 2.7 3 0 0 3 3 3 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Tho2 PF11262.8 EMD69622.1 - 0.17 11.1 8.4 0.2 10.9 8.4 1.1 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 Peptidase_S10 PF00450.22 EMD69623.1 - 1.2e-95 321.5 0.0 1.5e-95 321.1 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase CBFD_NFYB_HMF PF00808.23 EMD69624.1 - 5.3e-12 45.9 0.4 9.6e-12 45.0 0.4 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EMD69624.1 - 0.0019 18.6 0.5 0.0019 18.6 0.5 2.1 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 DUF2796 PF10986.8 EMD69624.1 - 0.031 14.3 0.2 0.041 13.8 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2796) Macro PF01661.21 EMD69625.1 - 4.4e-18 65.5 0.0 6.6e-18 64.9 0.0 1.3 1 0 0 1 1 1 1 Macro domain Rieske PF00355.26 EMD69626.1 - 9.4e-11 41.5 0.0 1.7e-10 40.7 0.0 1.5 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain UCR_TM PF02921.14 EMD69626.1 - 3.2e-09 37.1 0.5 1e-08 35.5 0.5 1.9 1 1 0 1 1 1 1 Ubiquinol cytochrome reductase transmembrane region BCIP PF13862.6 EMD69627.1 - 5e-73 245.3 0.0 6.3e-73 244.9 0.0 1.1 1 0 0 1 1 1 1 p21-C-terminal region-binding protein Filo_VP35 PF02097.15 EMD69627.1 - 0.14 11.2 0.0 0.2 10.7 0.0 1.2 1 0 0 1 1 1 0 Filoviridae VP35 GMP_synt_C PF00958.22 EMD69628.1 - 9.1e-43 144.2 0.0 1.8e-42 143.3 0.0 1.5 1 0 0 1 1 1 1 GMP synthase C terminal domain GATase PF00117.28 EMD69628.1 - 5e-40 137.3 0.0 7.6e-40 136.7 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I NAD_synthase PF02540.17 EMD69628.1 - 1.2e-11 44.3 0.2 1.7e-06 27.4 0.1 2.3 2 0 0 2 2 2 2 NAD synthase Peptidase_C26 PF07722.13 EMD69628.1 - 6.8e-07 29.3 0.1 1.4e-06 28.2 0.1 1.5 1 0 0 1 1 1 1 Peptidase C26 QueC PF06508.13 EMD69628.1 - 5.3e-05 22.8 0.0 0.0011 18.6 0.0 2.2 1 1 0 1 1 1 1 Queuosine biosynthesis protein QueC ThiI PF02568.14 EMD69628.1 - 0.00089 18.9 0.0 0.028 14.0 0.0 2.2 2 0 0 2 2 2 1 Thiamine biosynthesis protein (ThiI) tRNA_Me_trans PF03054.16 EMD69628.1 - 0.0016 17.3 0.2 0.0084 14.9 0.1 2.0 2 0 0 2 2 2 1 tRNA methyl transferase Arginosuc_synth PF00764.19 EMD69628.1 - 0.016 14.5 0.1 0.057 12.7 0.1 1.8 2 0 0 2 2 2 0 Arginosuccinate synthase UvrB_inter PF17757.1 EMD69628.1 - 0.089 13.0 0.0 0.22 11.7 0.0 1.6 1 0 0 1 1 1 0 UvrB interaction domain ATP_bind_3 PF01171.20 EMD69628.1 - 0.18 11.6 0.0 0.26 11.1 0.0 1.4 1 0 0 1 1 1 0 PP-loop family Voltage_CLC PF00654.20 EMD69629.1 - 2.2e-87 293.6 25.4 2.2e-87 293.6 25.4 1.4 2 0 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.28 EMD69629.1 - 1.1e-10 41.8 0.0 0.00034 21.0 0.0 2.6 2 0 0 2 2 2 2 CBS domain DHC_N1 PF08385.12 EMD69630.1 - 1e-127 427.2 6.0 1e-127 427.2 6.0 5.6 5 1 0 5 5 4 1 Dynein heavy chain, N-terminal region 1 AAA_6 PF12774.7 EMD69630.1 - 1.3e-126 422.0 4.3 1.4e-126 421.9 0.0 3.4 5 0 0 5 5 4 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 EMD69630.1 - 3.2e-117 392.0 8.7 3.2e-117 392.0 8.7 6.4 6 2 1 8 8 6 1 Dynein heavy chain, N-terminal region 2 AAA_9 PF12781.7 EMD69630.1 - 1.1e-75 253.6 0.8 1.1e-75 253.6 0.8 3.4 4 0 0 4 4 3 1 ATP-binding dynein motor region AAA_8 PF12780.7 EMD69630.1 - 1e-66 225.0 0.0 3.3e-65 220.0 0.0 3.1 2 0 0 2 2 2 1 P-loop containing dynein motor region D4 AAA_7 PF12775.7 EMD69630.1 - 8.2e-42 142.8 0.1 6.7e-36 123.5 0.0 4.9 5 0 0 5 5 5 2 P-loop containing dynein motor region MT PF12777.7 EMD69630.1 - 9.7e-41 139.9 9.4 9.7e-41 139.9 9.4 2.8 4 0 0 4 4 4 1 Microtubule-binding stalk of dynein motor AAA_5 PF07728.14 EMD69630.1 - 8e-31 106.9 0.0 1.6e-11 44.4 0.0 6.2 4 1 0 4 4 4 4 AAA domain (dynein-related subfamily) AAA_lid_11 PF18198.1 EMD69630.1 - 1.1e-29 103.4 0.0 3.3e-29 101.8 0.0 1.9 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 EMD69630.1 - 5.5e-29 100.7 0.4 1.6e-26 92.7 0.0 4.0 3 0 0 3 3 3 1 Dynein heavy chain region D6 P-loop domain Dynein_AAA_lid PF17852.1 EMD69630.1 - 3.5e-19 69.2 0.3 2.1e-18 66.6 0.0 2.6 2 0 0 2 2 1 1 Dynein heavy chain AAA lid domain AAA_22 PF13401.6 EMD69630.1 - 2.9e-16 60.0 0.5 0.014 15.6 0.0 7.3 5 1 1 6 6 6 3 AAA domain AAA PF00004.29 EMD69630.1 - 2.4e-12 47.4 0.0 0.0035 17.8 0.0 4.9 4 0 0 4 4 4 2 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 EMD69630.1 - 2.2e-09 37.6 6.2 0.031 14.4 0.0 5.8 5 0 0 5 5 5 3 AAA domain AAA_16 PF13191.6 EMD69630.1 - 7.1e-09 36.3 12.3 1.8 8.9 0.0 9.2 10 1 0 10 10 7 3 AAA ATPase domain AAA_18 PF13238.6 EMD69630.1 - 8.5e-09 36.1 0.2 0.17 12.4 0.0 5.3 4 0 0 4 4 4 2 AAA domain T2SSE PF00437.20 EMD69630.1 - 7.9e-06 25.1 0.0 0.028 13.5 0.0 3.6 3 0 0 3 3 3 1 Type II/IV secretion system protein FtsK_SpoIIIE PF01580.18 EMD69630.1 - 8e-06 25.4 0.0 0.29 10.5 0.1 4.0 3 0 0 3 3 3 2 FtsK/SpoIIIE family ABC_tran PF00005.27 EMD69630.1 - 2.1e-05 25.1 0.6 5.9 7.4 0.0 5.7 4 0 0 4 4 4 0 ABC transporter AAA_29 PF13555.6 EMD69630.1 - 4.7e-05 23.1 0.2 2.3 8.1 0.0 3.6 3 0 0 3 3 3 2 P-loop containing region of AAA domain AAA_lid_1 PF17857.1 EMD69630.1 - 4.8e-05 23.5 0.0 0.00027 21.1 0.0 2.4 1 0 0 1 1 1 1 AAA+ lid domain Mg_chelatase PF01078.21 EMD69630.1 - 8.5e-05 22.0 1.4 0.66 9.3 0.1 3.8 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_14 PF13173.6 EMD69630.1 - 9.1e-05 22.5 0.2 1.6 8.8 0.0 5.1 5 0 0 5 5 4 1 AAA domain AAA_24 PF13479.6 EMD69630.1 - 0.00029 20.6 0.1 5.7 6.6 0.0 5.3 4 0 0 4 4 4 0 AAA domain AAA_30 PF13604.6 EMD69630.1 - 0.00045 20.0 1.5 32 4.2 0.0 5.7 6 0 0 6 6 6 0 AAA domain AAA_19 PF13245.6 EMD69630.1 - 0.00046 20.5 2.0 0.27 11.6 0.0 4.9 5 0 0 5 5 4 1 AAA domain IstB_IS21 PF01695.17 EMD69630.1 - 0.00099 18.9 0.3 0.55 9.9 0.0 4.5 5 0 0 5 5 4 1 IstB-like ATP binding protein AAA_25 PF13481.6 EMD69630.1 - 0.004 16.8 0.0 0.2 11.2 0.0 3.2 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 EMD69630.1 - 0.019 15.4 0.1 43 4.6 0.0 4.4 4 0 0 4 4 4 0 RNA helicase Rad17 PF03215.15 EMD69630.1 - 0.033 14.1 0.6 5 7.0 0.0 4.0 4 0 0 4 4 4 0 Rad17 P-loop domain G-gamma PF00631.22 EMD69630.1 - 0.28 11.2 3.0 2.9 8.0 0.0 3.7 3 0 0 3 3 2 0 GGL domain PduV-EutP PF10662.9 EMD69630.1 - 0.43 10.3 2.1 11 5.7 0.1 4.1 5 0 0 5 5 4 0 Ethanolamine utilisation - propanediol utilisation NACHT PF05729.12 EMD69630.1 - 0.5 10.3 5.8 32 4.4 0.1 4.6 5 0 0 5 5 3 0 NACHT domain DUF1664 PF07889.12 EMD69630.1 - 8.7 6.4 32.2 0.13 12.3 1.0 7.8 6 1 1 7 7 6 0 Protein of unknown function (DUF1664) Fringe PF02434.16 EMD69632.1 - 0.0004 19.9 0.0 0.003 17.0 0.0 2.1 2 0 0 2 2 2 1 Fringe-like PAN_4 PF14295.6 EMD69632.1 - 0.0013 18.6 2.9 0.0032 17.3 2.9 1.7 1 0 0 1 1 1 1 PAN domain Galactosyl_T PF01762.21 EMD69632.1 - 0.019 14.8 0.0 0.08 12.7 0.0 1.9 1 1 1 2 2 2 0 Galactosyltransferase NYN PF01936.18 EMD69635.1 - 5.7e-31 108.0 0.0 7.7e-31 107.5 0.0 1.1 1 0 0 1 1 1 1 NYN domain PIN7 PF18475.1 EMD69635.1 - 0.13 12.9 0.0 0.27 11.9 0.0 1.6 1 1 0 1 1 1 0 PIN domain TPR_10 PF13374.6 EMD69636.1 - 1.4e-99 323.7 20.6 2.9e-13 49.2 0.0 9.0 9 0 0 9 9 8 8 Tetratricopeptide repeat TPR_12 PF13424.6 EMD69636.1 - 1.6e-98 323.1 35.8 1.1e-17 64.1 0.1 7.6 1 1 7 8 8 8 8 Tetratricopeptide repeat TPR_7 PF13176.6 EMD69636.1 - 3.1e-32 108.2 9.6 0.0029 17.5 0.0 8.7 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_4 PF07721.14 EMD69636.1 - 5.4e-19 66.8 1.1 0.14 12.9 0.0 9.4 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_1 PF00515.28 EMD69636.1 - 2.1e-18 65.3 7.1 0.15 11.9 0.0 8.4 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_2 PF07719.17 EMD69636.1 - 2.5e-17 61.5 10.7 0.087 13.0 0.0 8.8 9 0 0 9 9 8 5 Tetratricopeptide repeat TPR_19 PF14559.6 EMD69636.1 - 6.8e-17 61.7 5.2 0.15 12.6 0.0 8.9 2 2 6 8 8 8 3 Tetratricopeptide repeat TPR_17 PF13431.6 EMD69636.1 - 5.6e-16 57.7 12.8 0.068 13.6 0.1 8.5 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_16 PF13432.6 EMD69636.1 - 2.3e-14 53.8 0.9 0.36 11.5 0.1 8.6 4 1 3 7 7 7 3 Tetratricopeptide repeat NB-ARC PF00931.22 EMD69636.1 - 2.2e-13 50.0 0.9 1.6e-12 47.2 0.1 2.8 3 1 0 3 3 3 1 NB-ARC domain TPR_MalT PF17874.1 EMD69636.1 - 2.8e-13 50.0 29.1 4.6e-09 36.1 12.6 4.5 3 1 1 4 4 3 2 MalT-like TPR region HET PF06985.11 EMD69636.1 - 4.3e-09 36.9 18.2 5.6e-09 36.5 5.1 3.9 4 1 1 5 5 3 2 Heterokaryon incompatibility protein (HET) TPR_8 PF13181.6 EMD69636.1 - 3.8e-08 32.9 9.2 3.8 8.0 0.0 8.1 8 0 0 8 8 7 1 Tetratricopeptide repeat AAA_16 PF13191.6 EMD69636.1 - 7.9e-07 29.6 5.2 1.4e-06 28.8 0.3 3.1 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EMD69636.1 - 2.4e-06 27.9 0.0 1e-05 25.8 0.0 2.1 1 0 0 1 1 1 1 AAA domain TniB PF05621.11 EMD69636.1 - 9.6e-05 21.9 0.1 0.0027 17.2 0.0 2.9 2 1 1 3 3 3 1 Bacterial TniB protein RPN6_N PF18055.1 EMD69636.1 - 0.00026 21.3 8.2 0.34 11.3 0.7 4.9 2 2 3 5 5 5 2 26S proteasome regulatory subunit RPN6 N-terminal domain TPR_20 PF14561.6 EMD69636.1 - 0.00097 19.4 8.0 6.9 7.1 0.0 6.4 1 1 3 6 6 6 0 Tetratricopeptide repeat ATPase_2 PF01637.18 EMD69636.1 - 0.0011 18.9 0.0 0.0033 17.4 0.0 1.9 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea AAA PF00004.29 EMD69636.1 - 0.0027 18.1 0.0 0.017 15.5 0.0 2.5 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) PPR PF01535.20 EMD69636.1 - 0.0029 17.8 2.8 41 4.7 0.0 6.6 7 0 0 7 7 7 0 PPR repeat IstB_IS21 PF01695.17 EMD69636.1 - 0.0036 17.1 0.0 0.0099 15.6 0.0 1.7 1 0 0 1 1 1 1 IstB-like ATP binding protein zf-Mss51 PF13824.6 EMD69636.1 - 0.0073 16.4 5.3 9 6.5 0.1 5.3 6 0 0 6 6 5 0 Zinc-finger of mitochondrial splicing suppressor 51 AAA_5 PF07728.14 EMD69636.1 - 0.024 14.6 0.0 0.087 12.8 0.0 2.0 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) TPR_3 PF07720.12 EMD69636.1 - 0.032 14.2 0.0 7 6.8 0.0 4.6 7 0 0 7 7 5 0 Tetratricopeptide repeat NACHT PF05729.12 EMD69636.1 - 0.041 13.8 0.1 0.13 12.2 0.1 1.9 1 0 0 1 1 1 0 NACHT domain DUF1897 PF09005.10 EMD69636.1 - 0.064 12.8 13.4 20 4.7 0.1 5.7 6 0 0 6 6 6 0 Domain of unknown function (DUF1897) DUF1697 PF08002.11 EMD69636.1 - 0.079 13.4 2.4 29 5.1 0.0 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1697) DUF2664 PF10867.8 EMD69636.1 - 0.08 13.4 12.9 8.7 6.9 0.0 7.0 7 1 1 8 8 8 0 Protein of unknown function (DUF2664) TPR_14 PF13428.6 EMD69636.1 - 0.15 12.9 23.8 11 7.2 0.0 8.9 9 0 0 9 9 7 0 Tetratricopeptide repeat DNAJ_related PF12339.8 EMD69636.1 - 0.19 11.9 3.7 2.3 8.4 0.7 3.1 2 1 0 2 2 2 0 DNA-J related protein TPR_6 PF13174.6 EMD69636.1 - 5.3 7.9 17.2 46 5.0 0.1 7.5 7 1 0 7 7 6 0 Tetratricopeptide repeat DUF3157 PF11355.8 EMD69636.1 - 5.9 6.5 6.9 28 4.2 0.0 3.5 3 1 0 4 4 4 0 Protein of unknown function (DUF3157) HemY_N PF07219.13 EMD69637.1 - 0.21 11.8 0.5 0.51 10.6 0.5 1.6 1 0 0 1 1 1 0 HemY protein N-terminus VWA PF00092.28 EMD69638.1 - 0.00028 21.2 0.1 0.0014 18.9 0.1 2.0 1 1 0 1 1 1 1 von Willebrand factor type A domain YjeF_N PF03853.15 EMD69638.1 - 0.02 14.8 0.0 0.16 11.9 0.0 2.4 3 0 0 3 3 3 0 YjeF-related protein N-terminus ORF_12_N PF18042.1 EMD69638.1 - 0.039 14.4 0.0 0.087 13.2 0.0 1.5 1 0 0 1 1 1 0 ORF 12 gene product N-terminal SWIM PF04434.17 EMD69638.1 - 0.047 13.4 0.4 0.13 12.0 0.4 1.8 1 0 0 1 1 1 0 SWIM zinc finger zf-C2HC_2 PF13913.6 EMD69638.1 - 0.073 13.0 2.2 0.14 12.1 1.3 2.0 2 0 0 2 2 2 0 zinc-finger of a C2HC-type VWA_2 PF13519.6 EMD69638.1 - 0.13 12.9 0.0 37 5.0 0.0 3.3 2 1 0 2 2 2 0 von Willebrand factor type A domain Lipase_3 PF01764.25 EMD69639.1 - 8.3e-08 32.2 0.0 1.2e-07 31.7 0.0 1.4 1 1 0 1 1 1 1 Lipase (class 3) DLH PF01738.18 EMD69639.1 - 0.0059 16.2 0.0 0.022 14.3 0.0 1.8 2 0 0 2 2 2 1 Dienelactone hydrolase family Abhydrolase_2 PF02230.16 EMD69639.1 - 0.04 13.7 0.0 0.065 13.0 0.0 1.3 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase Abhydrolase_3 PF07859.13 EMD69639.1 - 0.074 12.9 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold AIRS PF00586.24 EMD69639.1 - 0.098 13.3 0.0 0.19 12.4 0.0 1.5 1 1 0 1 1 1 0 AIR synthase related protein, N-terminal domain DUF2974 PF11187.8 EMD69639.1 - 0.11 12.0 0.0 0.19 11.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) BTB PF00651.31 EMD69640.1 - 1.1e-07 32.0 0.2 2.5e-07 30.9 0.2 1.5 1 0 0 1 1 1 1 BTB/POZ domain Lipase_GDSL_2 PF13472.6 EMD69641.1 - 0.0003 21.2 0.0 0.00042 20.8 0.0 1.3 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family TMF_TATA_bd PF12325.8 EMD69642.1 - 0.01 16.0 3.3 0.01 16.0 3.3 5.3 4 1 0 5 5 5 0 TATA element modulatory factor 1 TATA binding DUF2184 PF09950.9 EMD69642.1 - 0.064 12.6 0.0 0.13 11.7 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2184) DUF1192 PF06698.11 EMD69642.1 - 0.13 12.4 6.7 2 8.5 0.0 3.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1192) PMEI PF04043.15 EMD69642.1 - 0.41 11.0 3.0 0.51 10.7 0.8 2.4 2 0 0 2 2 2 0 Plant invertase/pectin methylesterase inhibitor MT PF12777.7 EMD69642.1 - 0.99 8.4 8.4 32 3.4 8.4 2.3 1 1 0 1 1 1 0 Microtubule-binding stalk of dynein motor PRKG1_interact PF15898.5 EMD69642.1 - 2.3 9.1 37.7 0.51 11.3 6.3 5.6 2 1 3 5 5 5 0 cGMP-dependent protein kinase interacting domain DUF334 PF03904.13 EMD69642.1 - 7.8 6.0 12.2 5.8 6.4 5.9 2.6 1 1 0 2 2 2 0 Domain of unknown function (DUF334) Filament PF00038.21 EMD69642.1 - 8.7 5.8 42.4 0.29 10.7 10.1 3.6 2 1 1 3 3 3 0 Intermediate filament protein Sugar_tr PF00083.24 EMD69643.1 - 1.4e-77 261.5 23.8 1.6e-77 261.3 23.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD69643.1 - 2.8e-31 108.7 23.0 1.2e-29 103.4 13.9 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EMD69643.1 - 1.4e-06 27.2 23.9 2.5e-06 26.3 7.6 2.3 2 0 0 2 2 2 2 MFS/sugar transport protein TRI12 PF06609.13 EMD69643.1 - 6.7e-05 21.5 2.9 0.00011 20.8 2.9 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_4 PF06779.14 EMD69643.1 - 0.0067 15.8 13.8 0.067 12.5 0.2 3.0 2 1 1 3 3 3 2 Uncharacterised MFS-type transporter YbfB YrhK PF14145.6 EMD69643.1 - 0.02 14.8 0.6 0.02 14.8 0.6 3.3 3 0 0 3 3 3 0 YrhK-like protein MARVEL PF01284.23 EMD69644.1 - 1.8e-20 73.4 23.9 2.1e-20 73.2 23.9 1.0 1 0 0 1 1 1 1 Membrane-associating domain Potass_KdpF PF09604.10 EMD69644.1 - 7.5 6.7 9.2 4.7 7.3 0.4 3.4 3 0 0 3 3 3 0 F subunit of K+-transporting ATPase (Potass_KdpF) Antimicrobial_1 PF08018.11 EMD69645.1 - 0.0084 16.2 1.1 0.014 15.6 1.1 1.4 1 0 0 1 1 1 1 Frog antimicrobial peptide DPPIV_N PF00930.21 EMD69646.1 - 4.8e-103 344.6 2.3 7.3e-103 344.0 2.3 1.3 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.21 EMD69646.1 - 6.6e-38 130.3 0.2 1.2e-37 129.5 0.2 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S15 PF02129.18 EMD69646.1 - 0.00038 20.1 1.5 0.0011 18.6 1.5 1.8 1 1 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) PD40 PF07676.12 EMD69646.1 - 0.038 13.9 0.1 0.038 13.9 0.1 2.6 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat DUF2920 PF11144.8 EMD69646.1 - 0.084 12.0 0.0 0.15 11.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2920) LSM PF01423.22 EMD69647.1 - 1.6e-17 63.0 0.0 2e-17 62.6 0.0 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EMD69647.1 - 0.047 13.8 0.0 0.049 13.8 0.0 1.2 1 0 0 1 1 1 0 Ataxin 2 SM domain PITH PF06201.13 EMD69648.1 - 2.3e-44 151.3 0.0 2.8e-44 151.0 0.0 1.1 1 0 0 1 1 1 1 PITH domain Sad1_UNC PF07738.13 EMD69648.1 - 0.055 13.5 0.0 0.08 13.0 0.0 1.2 1 0 0 1 1 1 0 Sad1 / UNC-like C-terminal Snf7 PF03357.21 EMD69649.1 - 6.3e-33 113.8 14.8 6.3e-33 113.8 14.8 1.4 2 0 0 2 2 2 1 Snf7 Silic_transp PF03842.13 EMD69649.1 - 0.06 11.6 1.0 0.085 11.1 1.0 1.2 1 0 0 1 1 1 0 Silicon transporter Ead_Ea22 PF13935.6 EMD69649.1 - 8.2 7.1 13.7 0.42 11.3 5.1 2.1 1 1 0 2 2 2 0 Ead/Ea22-like protein AAA PF00004.29 EMD69650.1 - 2.2e-88 293.4 0.0 3e-44 150.6 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EMD69650.1 - 2.7e-17 62.3 0.5 3e-07 30.1 0.1 2.8 2 0 0 2 2 2 2 AAA+ lid domain AAA_16 PF13191.6 EMD69650.1 - 2.2e-12 47.7 2.9 0.0035 17.7 0.0 4.8 3 2 2 5 5 4 2 AAA ATPase domain RuvB_N PF05496.12 EMD69650.1 - 8.1e-12 45.2 0.0 0.0002 21.2 0.0 2.7 2 1 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EMD69650.1 - 6.9e-11 42.6 2.0 0.016 15.5 0.1 5.3 2 2 2 4 4 4 2 AAA domain AAA_5 PF07728.14 EMD69650.1 - 2.1e-10 40.8 0.1 0.00077 19.5 0.0 3.6 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 EMD69650.1 - 3.8e-09 36.8 0.0 0.0046 17.1 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_2 PF07724.14 EMD69650.1 - 1.3e-08 35.2 0.0 0.0021 18.2 0.0 3.1 2 1 0 2 2 2 2 AAA domain (Cdc48 subfamily) TIP49 PF06068.13 EMD69650.1 - 2.2e-08 33.7 0.1 0.0011 18.2 0.0 2.6 2 1 1 3 3 3 2 TIP49 P-loop domain AAA_14 PF13173.6 EMD69650.1 - 5.1e-07 29.8 0.0 0.045 13.8 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_28 PF13521.6 EMD69650.1 - 6.9e-07 29.6 0.0 0.031 14.5 0.0 2.7 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.22 EMD69650.1 - 9.9e-07 29.1 0.0 0.077 13.4 0.0 2.8 2 1 0 2 2 2 2 RNA helicase Zeta_toxin PF06414.12 EMD69650.1 - 1.1e-06 28.0 0.1 0.065 12.5 0.0 3.3 3 0 0 3 3 3 2 Zeta toxin AAA_3 PF07726.11 EMD69650.1 - 1.2e-06 28.4 0.0 0.0078 16.1 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 EMD69650.1 - 1.4e-06 28.9 2.6 0.082 13.4 0.0 4.2 5 0 0 5 5 4 2 AAA domain TsaE PF02367.17 EMD69650.1 - 1.5e-06 28.2 0.0 0.053 13.5 0.0 2.8 3 0 0 3 3 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE Rad17 PF03215.15 EMD69650.1 - 4.9e-06 26.6 0.0 0.03 14.2 0.0 2.8 3 0 0 3 3 2 2 Rad17 P-loop domain Mg_chelatase PF01078.21 EMD69650.1 - 6.1e-06 25.8 0.2 0.048 13.0 0.1 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 EMD69650.1 - 1.2e-05 25.1 0.1 0.058 13.1 0.0 2.9 3 0 0 3 3 3 2 IstB-like ATP binding protein ATPase PF06745.13 EMD69650.1 - 7e-05 22.3 0.1 0.33 10.2 0.0 2.8 2 1 1 3 3 3 2 KaiC AAA_17 PF13207.6 EMD69650.1 - 0.00014 22.3 1.1 0.51 10.8 0.0 3.4 3 1 1 4 4 2 2 AAA domain ABC_tran PF00005.27 EMD69650.1 - 0.00015 22.3 0.0 0.13 12.7 0.0 3.1 3 0 0 3 3 2 1 ABC transporter AAA_7 PF12775.7 EMD69650.1 - 0.00022 20.8 0.0 1.1 8.7 0.0 3.0 2 1 0 2 2 2 2 P-loop containing dynein motor region AAA_11 PF13086.6 EMD69650.1 - 0.00026 20.9 2.8 1.6 8.4 0.0 3.3 3 0 0 3 3 3 2 AAA domain NACHT PF05729.12 EMD69650.1 - 0.00027 20.9 1.1 1.1 9.2 0.0 3.5 4 0 0 4 4 3 2 NACHT domain DUF815 PF05673.13 EMD69650.1 - 0.00036 19.8 0.0 0.091 11.9 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF815) Sigma54_activat PF00158.26 EMD69650.1 - 0.00041 20.1 0.0 0.19 11.4 0.0 2.9 3 0 0 3 3 2 1 Sigma-54 interaction domain SKI PF01202.22 EMD69650.1 - 0.00046 20.4 0.2 0.34 11.0 0.0 3.3 3 0 0 3 3 2 1 Shikimate kinase Cytidylate_kin2 PF13189.6 EMD69650.1 - 0.0015 18.7 0.0 0.28 11.3 0.0 2.4 2 0 0 2 2 2 1 Cytidylate kinase-like family AAA_25 PF13481.6 EMD69650.1 - 0.0021 17.7 1.7 1.5 8.3 0.2 3.2 2 1 0 2 2 2 1 AAA domain NB-ARC PF00931.22 EMD69650.1 - 0.0027 17.0 0.0 2.6 7.2 0.0 2.4 2 0 0 2 2 2 2 NB-ARC domain PhoH PF02562.16 EMD69650.1 - 0.0033 16.9 0.1 0.72 9.3 0.1 2.7 2 0 0 2 2 2 1 PhoH-like protein Viral_helicase1 PF01443.18 EMD69650.1 - 0.0036 17.1 0.0 2.5 7.8 0.0 2.4 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase AAA_24 PF13479.6 EMD69650.1 - 0.0053 16.5 0.1 0.96 9.1 0.0 2.6 2 0 0 2 2 2 1 AAA domain Sigma54_activ_2 PF14532.6 EMD69650.1 - 0.0071 16.5 0.0 3 8.0 0.0 2.5 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_19 PF13245.6 EMD69650.1 - 0.0081 16.5 1.9 9.4 6.6 0.1 3.6 3 1 0 3 3 3 0 AAA domain TniB PF05621.11 EMD69650.1 - 0.0091 15.4 0.0 2 7.8 0.0 3.0 3 0 0 3 3 3 1 Bacterial TniB protein ATPase_2 PF01637.18 EMD69650.1 - 0.014 15.3 0.0 4.8 7.0 0.0 3.2 3 1 1 4 4 3 0 ATPase domain predominantly from Archaea ResIII PF04851.15 EMD69650.1 - 0.051 13.6 0.1 16 5.5 0.0 2.9 3 0 0 3 3 2 0 Type III restriction enzyme, res subunit CPT PF07931.12 EMD69650.1 - 0.053 13.4 0.0 1.5 8.6 0.0 2.4 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein Cytidylate_kin PF02224.18 EMD69650.1 - 0.07 12.9 0.0 5.3 6.7 0.0 2.5 2 0 0 2 2 2 0 Cytidylate kinase dCache_2 PF08269.11 EMD69650.1 - 0.071 12.3 0.3 0.13 11.5 0.3 1.3 1 0 0 1 1 1 0 Cache domain NTPase_1 PF03266.15 EMD69650.1 - 0.13 12.2 0.3 7.2 6.5 0.0 2.8 2 1 0 2 2 2 0 NTPase AAA_30 PF13604.6 EMD69650.1 - 0.13 11.9 1.6 27 4.4 0.1 3.5 4 0 0 4 4 3 0 AAA domain Parvo_NS1 PF01057.17 EMD69650.1 - 0.2 10.7 0.1 2.9 6.9 0.1 2.1 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 AAA_29 PF13555.6 EMD69650.1 - 0.21 11.3 0.0 13 5.6 0.0 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain ADH_zinc_N_2 PF13602.6 EMD69653.1 - 6.1e-12 46.7 0.0 1.9e-11 45.1 0.0 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 EMD69653.1 - 5.3e-10 39.4 0.1 1.1e-09 38.4 0.1 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EMD69653.1 - 6.8e-06 25.9 0.0 1.4e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_N_2 PF16884.5 EMD69653.1 - 0.0044 16.9 0.0 0.0094 15.8 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase VCPO_N PF17897.1 EMD69654.1 - 3.8e-106 353.7 1.0 6e-106 353.0 1.0 1.3 1 0 0 1 1 1 1 Vanadium chloroperoxidase N-terminal domain PAP2 PF01569.21 EMD69654.1 - 1.2e-09 38.1 0.0 2.1e-09 37.3 0.0 1.4 1 0 0 1 1 1 1 PAP2 superfamily CUE PF02845.16 EMD69655.1 - 1.4e-11 43.9 0.0 2.5e-11 43.0 0.0 1.4 1 0 0 1 1 1 1 CUE domain Pyr_redox_3 PF13738.6 EMD69657.1 - 1.4e-16 60.7 0.0 1.7e-13 50.5 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EMD69657.1 - 4.5e-16 59.0 0.0 3.1e-13 49.6 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 EMD69657.1 - 5.8e-12 44.8 0.1 5.4e-11 41.6 0.1 2.0 1 1 0 1 1 1 1 Flavin-binding monooxygenase-like K_oxygenase PF13434.6 EMD69657.1 - 8.9e-09 34.9 0.1 7.2e-07 28.7 0.0 2.6 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 EMD69657.1 - 0.002 18.3 0.0 0.016 15.4 0.0 2.6 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain 2-Hacid_dh_C PF02826.19 EMD69657.1 - 0.0035 16.7 0.0 0.05 13.0 0.0 2.2 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyr_redox PF00070.27 EMD69657.1 - 0.019 15.5 0.2 1.2 9.8 0.0 3.0 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 EMD69657.1 - 0.054 13.4 0.1 0.69 9.8 0.0 2.2 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FAD_binding_3 PF01494.19 EMD69657.1 - 0.066 12.4 0.0 1.7 7.8 0.0 2.4 3 0 0 3 3 3 0 FAD binding domain TrkA_N PF02254.18 EMD69657.1 - 0.17 12.1 0.0 0.87 9.9 0.0 2.0 2 0 0 2 2 2 0 TrkA-N domain adh_short PF00106.25 EMD69658.1 - 7.8e-29 100.5 0.0 1.1e-28 100.1 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD69658.1 - 5e-16 59.0 0.0 6.3e-16 58.6 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD69658.1 - 0.0031 17.4 0.1 0.0065 16.4 0.1 1.6 1 1 0 1 1 1 1 KR domain F420H2_quin_red PF04075.14 EMD69659.1 - 0.041 14.0 5.5 7 6.8 0.0 4.1 5 0 0 5 5 5 0 F420H(2)-dependent quinone reductase DUF3274 PF11678.8 EMD69659.1 - 0.42 9.8 2.0 9.4 5.4 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3274) Sulfate_transp PF00916.20 EMD69660.1 - 4.8e-86 288.9 16.5 6e-86 288.6 16.5 1.1 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 EMD69660.1 - 1.2e-12 47.5 0.0 2.2e-12 46.6 0.0 1.4 1 0 0 1 1 1 1 STAS domain STAS_2 PF13466.6 EMD69660.1 - 0.014 15.7 0.0 0.029 14.7 0.0 1.5 1 0 0 1 1 1 0 STAS domain MotB_plug PF13677.6 EMD69660.1 - 0.082 12.5 0.6 0.23 11.1 0.6 1.8 1 0 0 1 1 1 0 Membrane MotB of proton-channel complex MotA/MotB Peptidase_M3 PF01432.20 EMD69661.1 - 0.046 13.0 0.1 0.073 12.3 0.1 1.4 1 0 0 1 1 1 0 Peptidase family M3 Peptidase_M32 PF02074.15 EMD69661.1 - 5.9 5.5 7.4 0.9 8.2 2.9 1.8 2 0 0 2 2 2 0 Carboxypeptidase Taq (M32) metallopeptidase TDRP PF15683.5 EMD69662.1 - 0.06 13.3 0.5 6.9 6.6 0.0 2.5 2 0 0 2 2 2 0 Testis development-related protein EMP24_GP25L PF01105.24 EMD69663.1 - 2.1e-47 161.4 0.3 2.4e-47 161.2 0.3 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Myb_DNA-bind_6 PF13921.6 EMD69664.1 - 0.012 15.8 0.8 0.057 13.7 0.1 2.3 2 0 0 2 2 2 0 Myb-like DNA-binding domain Rap1_C PF11626.8 EMD69664.1 - 0.027 14.5 0.3 1.7 8.8 0.3 2.7 1 1 0 1 1 1 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain Myb_DNA-binding PF00249.31 EMD69664.1 - 0.047 13.9 0.2 0.13 12.5 0.2 1.8 1 0 0 1 1 1 0 Myb-like DNA-binding domain Alpha-amylase PF00128.24 EMD69665.1 - 1.9e-115 386.1 1.1 1.9e-115 386.1 1.1 1.4 2 0 0 2 2 2 1 Alpha amylase, catalytic domain hDGE_amylase PF14701.6 EMD69665.1 - 2.1e-05 23.8 0.0 3.7e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 Glycogen debranching enzyme, glucanotransferase domain Malt_amylase_C PF16657.5 EMD69665.1 - 0.00045 20.3 0.0 0.0011 19.1 0.0 1.7 1 0 0 1 1 1 1 Maltogenic Amylase, C-terminal domain Alpha-amylase_C PF02806.18 EMD69665.1 - 0.082 13.4 0.0 0.24 11.9 0.0 1.8 1 0 0 1 1 1 0 Alpha amylase, C-terminal all-beta domain DUF3603 PF12227.8 EMD69665.1 - 8.2 5.7 7.4 10 5.3 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3603) AA_permease PF00324.21 EMD69666.1 - 0.0017 17.0 0.3 0.0029 16.2 0.3 1.3 1 0 0 1 1 1 1 Amino acid permease FAD_binding_4 PF01565.23 EMD69668.1 - 7.3e-23 80.8 2.3 1.1e-22 80.2 2.3 1.3 1 0 0 1 1 1 1 FAD binding domain 2-Hacid_dh_C PF02826.19 EMD69669.1 - 1.3e-44 151.7 0.0 2.2e-44 151.0 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EMD69669.1 - 1.4e-29 102.5 0.0 1.6e-29 102.2 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain F420_oxidored PF03807.17 EMD69669.1 - 0.0017 18.9 0.0 0.0051 17.4 0.0 1.9 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent AlaDh_PNT_C PF01262.21 EMD69669.1 - 0.0064 15.8 0.0 0.01 15.2 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_2 PF03446.15 EMD69669.1 - 0.069 13.3 0.0 0.2 11.8 0.0 1.8 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase DAO PF01266.24 EMD69670.1 - 3.2e-44 152.0 0.9 3.8e-44 151.7 0.9 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EMD69670.1 - 6.5e-06 25.6 2.7 0.014 14.6 0.1 2.5 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EMD69670.1 - 2.5e-05 23.5 0.1 0.091 11.8 0.0 2.4 2 0 0 2 2 2 2 Lycopene cyclase protein NAD_binding_8 PF13450.6 EMD69670.1 - 0.0018 18.5 0.1 0.0018 18.5 0.1 1.8 2 0 0 2 2 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 EMD69670.1 - 0.0087 16.1 0.4 0.018 15.0 0.1 1.7 2 0 0 2 2 2 1 FAD-NAD(P)-binding Thi4 PF01946.17 EMD69670.1 - 0.0087 15.3 0.0 0.13 11.5 0.0 2.2 2 0 0 2 2 2 1 Thi4 family K_oxygenase PF13434.6 EMD69670.1 - 0.02 14.0 0.0 0.21 10.7 0.0 2.0 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) Hypoth_Ymh PF09509.10 EMD69670.1 - 0.029 14.2 0.0 7.3 6.5 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (Hypoth_ymh) HI0933_like PF03486.14 EMD69670.1 - 0.06 12.0 0.2 3.5 6.2 0.1 2.2 2 0 0 2 2 2 0 HI0933-like protein OAS1_C PF10421.9 EMD69670.1 - 0.11 12.0 0.0 0.19 11.2 0.0 1.3 1 0 0 1 1 1 0 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus AftA_N PF12250.8 EMD69670.1 - 0.24 10.1 0.0 0.34 9.6 0.0 1.1 1 0 0 1 1 1 0 Arabinofuranosyltransferase N terminal Sugar_tr PF00083.24 EMD69671.1 - 7.6e-23 81.1 14.4 1.1e-22 80.5 13.5 1.7 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD69671.1 - 3.5e-22 78.8 32.8 2.7e-18 66.0 14.2 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily GMC_oxred_N PF00732.19 EMD69672.1 - 6.9e-54 183.2 0.0 9.8e-54 182.7 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EMD69672.1 - 2.4e-35 122.2 0.3 4.3e-35 121.3 0.3 1.4 1 0 0 1 1 1 1 GMC oxidoreductase Lycopene_cycl PF05834.12 EMD69672.1 - 0.00076 18.6 0.0 0.0082 15.2 0.1 2.0 2 0 0 2 2 2 1 Lycopene cyclase protein DAO PF01266.24 EMD69672.1 - 0.0054 16.3 0.2 1.1 8.8 0.0 3.2 4 0 0 4 4 4 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EMD69672.1 - 0.025 13.8 0.0 4.1 6.6 0.0 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EMD69672.1 - 0.044 12.9 0.1 0.62 9.1 0.0 2.1 2 0 0 2 2 2 0 FAD binding domain GIDA PF01134.22 EMD69672.1 - 0.056 12.5 0.2 0.14 11.2 0.0 1.7 2 0 0 2 2 2 0 Glucose inhibited division protein A ABC2_membrane_3 PF12698.7 EMD69673.1 - 0.083 12.0 4.6 0.12 11.4 4.6 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein DUF3902 PF13042.6 EMD69673.1 - 0.1 12.2 5.2 0.25 10.9 5.2 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3902) ABC2_membrane_5 PF13346.6 EMD69673.1 - 0.77 9.3 8.0 1.1 8.8 8.0 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein PhyH PF05721.13 EMD69675.1 - 8.4e-14 52.3 0.0 1.1e-13 51.9 0.0 1.2 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) Ycf9 PF01737.17 EMD69675.1 - 0.2 11.5 0.4 0.41 10.5 0.1 1.6 2 0 0 2 2 2 0 YCF9 Glutaredoxin PF00462.24 EMD69676.1 - 1.6e-11 44.3 0.0 4.3e-11 42.9 0.0 1.8 1 0 0 1 1 1 1 Glutaredoxin TraF PF13728.6 EMD69676.1 - 0.018 14.9 0.5 0.37 10.6 0.0 2.1 2 0 0 2 2 2 0 F plasmid transfer operon protein RXLR PF16810.5 EMD69676.1 - 0.021 15.3 0.1 0.037 14.4 0.1 1.5 1 0 0 1 1 1 0 RXLR phytopathogen effector protein, Avirulence activity DUF4746 PF15928.5 EMD69677.1 - 0.0084 15.6 0.9 0.007 15.8 0.9 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4746) TTKRSYEDQ PF10212.9 EMD69677.1 - 0.39 9.7 4.3 0.45 9.5 4.3 1.1 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein Plasmodium_Vir PF05795.11 EMD69677.1 - 0.82 9.0 3.3 0.96 8.8 3.3 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein AP1AR PF15745.5 EMD69677.1 - 0.94 9.0 10.8 1.3 8.6 10.8 1.2 1 0 0 1 1 1 0 AP-1 complex-associated regulatory protein XRN_M PF17846.1 EMD69677.1 - 1.6 7.6 5.8 2.1 7.2 5.8 1.1 1 0 0 1 1 1 0 Xrn1 helical domain Atg14 PF10186.9 EMD69677.1 - 1.9 7.5 9.2 2.8 6.9 9.2 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Presenilin PF01080.17 EMD69677.1 - 2 7.1 4.1 2.3 6.9 4.1 1.1 1 0 0 1 1 1 0 Presenilin DUF4407 PF14362.6 EMD69677.1 - 3.4 6.9 9.0 4.3 6.6 9.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Menin PF05053.13 EMD69677.1 - 4.7 5.4 9.2 6 5.1 9.2 1.1 1 0 0 1 1 1 0 Menin DUF4690 PF15756.5 EMD69678.1 - 0.033 14.8 0.3 0.033 14.8 0.3 1.9 2 0 0 2 2 2 0 Small Novel Rich in Cartilage Podoplanin PF05808.11 EMD69678.1 - 0.11 12.6 2.1 0.2 11.8 0.4 2.1 2 0 0 2 2 2 0 Podoplanin DUF4834 PF16118.5 EMD69678.1 - 0.14 13.2 0.0 1.9 9.5 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Glycophorin_A PF01102.18 EMD69678.1 - 0.14 12.4 1.1 0.4 10.9 0.0 2.0 2 0 0 2 2 2 0 Glycophorin A CYYR1 PF10873.8 EMD69678.1 - 0.75 10.2 10.1 0.073 13.5 1.9 2.5 2 0 0 2 2 2 0 Cysteine and tyrosine-rich protein 1 Syndecan PF01034.20 EMD69678.1 - 3 7.8 5.3 6 6.9 5.3 1.5 1 0 0 1 1 1 0 Syndecan domain Adeno_E3_CR2 PF02439.15 EMD69678.1 - 6 6.7 6.4 16 5.4 6.4 1.6 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 ThiF PF00899.21 EMD69679.1 - 7e-111 369.4 0.0 1.8e-76 256.7 0.0 2.5 2 1 0 2 2 2 2 ThiF family UBA_e1_thiolCys PF10585.9 EMD69679.1 - 1.4e-92 310.2 0.3 2.5e-92 309.4 0.3 1.4 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site E1_UFD PF09358.10 EMD69679.1 - 6.6e-33 113.3 0.4 1.3e-32 112.3 0.4 1.5 1 0 0 1 1 1 1 Ubiquitin fold domain E1_FCCH PF16190.5 EMD69679.1 - 1.1e-30 105.6 0.0 2.4e-30 104.5 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 FCCH domain E1_4HB PF16191.5 EMD69679.1 - 3.9e-25 87.8 1.9 3.9e-25 87.8 1.9 2.1 2 0 0 2 2 2 1 Ubiquitin-activating enzyme E1 four-helix bundle ParA PF10609.9 EMD69680.1 - 3.7e-94 314.8 0.0 4.3e-94 314.6 0.0 1.0 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 EMD69680.1 - 2.9e-06 27.4 0.0 1.1e-05 25.5 0.0 1.9 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 EMD69680.1 - 2.3e-05 24.4 0.0 9.6e-05 22.4 0.0 1.8 1 1 0 1 1 1 1 AAA domain ArsA_ATPase PF02374.15 EMD69680.1 - 0.00027 20.2 1.1 0.00085 18.6 0.4 2.0 1 1 1 2 2 2 1 Anion-transporting ATPase AAA_26 PF13500.6 EMD69680.1 - 0.0017 18.2 0.1 0.033 14.0 0.0 2.1 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 EMD69680.1 - 0.022 14.7 0.1 0.046 13.6 0.1 1.5 1 0 0 1 1 1 0 RsgA GTPase CLP1_P PF16575.5 EMD69680.1 - 0.033 14.0 0.0 0.052 13.3 0.0 1.3 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop MipZ PF09140.11 EMD69680.1 - 0.043 13.1 0.0 0.11 11.8 0.0 1.6 1 1 0 1 1 1 0 ATPase MipZ Fer4_NifH PF00142.18 EMD69680.1 - 0.047 13.1 0.0 1.4 8.3 0.1 2.2 2 0 0 2 2 2 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family Rad17 PF03215.15 EMD69680.1 - 0.073 13.0 0.0 0.11 12.4 0.0 1.2 1 0 0 1 1 1 0 Rad17 P-loop domain PhoD PF09423.10 EMD69681.1 - 2.8e-05 23.3 0.9 0.002 17.2 0.4 2.5 2 1 0 2 2 2 2 PhoD-like phosphatase DUF4253 PF14062.6 EMD69681.1 - 0.1 12.8 0.0 0.25 11.5 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4253) FAD_binding_4 PF01565.23 EMD69684.1 - 2.1e-20 72.9 0.9 4e-20 72.0 0.9 1.5 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EMD69684.1 - 8.1e-12 45.1 0.1 1.9e-11 43.9 0.1 1.7 1 0 0 1 1 1 1 Berberine and berberine like DUF3105 PF11303.8 EMD69684.1 - 0.047 13.9 0.1 0.11 12.6 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3105) FMN_dh PF01070.18 EMD69685.1 - 1e-113 379.9 0.0 1.2e-113 379.7 0.0 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.28 EMD69685.1 - 5.4e-20 71.3 0.0 9.8e-20 70.5 0.0 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Glu_synthase PF01645.17 EMD69685.1 - 3e-05 23.3 0.0 4.8e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase NMO PF03060.15 EMD69685.1 - 7.5e-05 22.3 0.0 0.00012 21.6 0.0 1.2 1 0 0 1 1 1 1 Nitronate monooxygenase ThiG PF05690.14 EMD69685.1 - 0.00057 19.3 0.0 0.016 14.5 0.0 2.3 2 0 0 2 2 2 1 Thiazole biosynthesis protein ThiG IMPDH PF00478.25 EMD69685.1 - 0.0041 16.2 0.0 0.013 14.5 0.0 1.8 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain Methyltransf_25 PF13649.6 EMD69686.1 - 4.5e-09 36.9 0.0 8.4e-09 36.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMD69686.1 - 3.4e-08 34.0 0.0 6.1e-08 33.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EMD69686.1 - 4.2e-06 26.7 0.0 6.8e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EMD69686.1 - 8.1e-06 25.3 0.0 0.0009 18.6 0.0 2.1 2 0 0 2 2 2 2 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 EMD69686.1 - 1.4e-05 25.7 0.0 2.3e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMD69686.1 - 0.00031 20.6 0.0 0.00043 20.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain 4HBT_3 PF13622.6 EMD69687.1 - 4.5e-25 89.3 5.0 4.7e-24 86.0 5.0 2.2 1 1 0 1 1 1 1 Thioesterase-like superfamily Acyl_CoA_thio PF02551.15 EMD69687.1 - 7.9e-05 22.5 1.2 0.32 10.8 0.1 3.9 3 1 0 3 3 3 3 Acyl-CoA thioesterase AA_permease_2 PF13520.6 EMD69688.1 - 4.4e-54 183.9 35.5 5.8e-54 183.5 35.5 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EMD69688.1 - 7.6e-22 77.5 39.3 5.8e-21 74.6 39.3 2.0 1 1 0 1 1 1 1 Amino acid permease Apolipoprotein PF01442.18 EMD69689.1 - 3.6e-05 23.7 12.1 0.024 14.5 1.7 3.4 1 1 1 2 2 2 2 Apolipoprotein A1/A4/E domain DUF4795 PF16043.5 EMD69689.1 - 6.1e-05 22.7 0.6 6.1e-05 22.7 0.6 2.6 1 1 1 2 2 2 1 Domain of unknown function (DUF4795) XH PF03469.14 EMD69689.1 - 0.00044 20.2 7.3 0.27 11.1 0.0 4.0 2 1 2 4 4 4 2 XH domain PhoU_div PF01865.16 EMD69689.1 - 0.0094 15.3 2.9 0.51 9.6 0.1 2.8 3 0 0 3 3 3 1 Protein of unknown function DUF47 DUF4320 PF14208.6 EMD69689.1 - 0.018 15.1 0.1 0.041 14.0 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4320) Phasin_2 PF09361.10 EMD69689.1 - 0.032 14.5 7.0 12 6.2 1.0 4.7 3 2 1 4 4 4 0 Phasin protein Ntox35 PF15534.6 EMD69689.1 - 0.043 14.3 2.2 0.6 10.6 1.1 2.9 2 0 0 2 2 2 0 Bacterial toxin 35 Peptidase_M41 PF01434.18 EMD69689.1 - 0.074 12.9 5.8 0.4 10.5 1.4 3.2 1 1 1 3 3 3 0 Peptidase family M41 HAUS-augmin3 PF14932.6 EMD69689.1 - 0.13 11.8 7.4 7.6 6.0 0.0 3.1 2 1 0 3 3 3 0 HAUS augmin-like complex subunit 3 PIN_12 PF16289.5 EMD69689.1 - 0.19 12.2 0.1 0.19 12.2 0.1 2.9 1 1 2 3 3 3 0 PIN domain DnaI_N PF07319.11 EMD69689.1 - 0.32 11.7 2.4 1.2 9.8 0.1 2.9 3 0 0 3 3 3 0 Primosomal protein DnaI N-terminus HisKA_3 PF07730.13 EMD69689.1 - 0.45 11.1 6.3 12 6.6 0.0 4.2 4 1 1 5 5 5 0 Histidine kinase PhoU PF01895.19 EMD69689.1 - 0.47 11.0 2.8 6.5 7.3 0.0 3.5 3 1 0 3 3 3 0 PhoU domain DUF1771 PF08590.10 EMD69689.1 - 0.64 10.4 8.8 3.1 8.3 3.4 4.4 3 2 1 4 4 4 0 Domain of unknown function (DUF1771) TPR_10 PF13374.6 EMD69689.1 - 0.78 9.7 6.7 59 3.7 0.1 4.2 3 1 1 4 4 4 0 Tetratricopeptide repeat CarD_CdnL_TRCF PF02559.16 EMD69689.1 - 2.6 8.8 12.2 4.6 8.0 2.0 4.5 2 1 1 4 4 4 0 CarD-like/TRCF domain FlgN PF05130.12 EMD69689.1 - 3.1 8.3 9.4 16 6.0 0.9 3.6 2 1 2 4 4 4 0 FlgN protein DUF883 PF05957.13 EMD69689.1 - 3.2 8.4 0.0 3.2 8.4 0.0 5.7 3 2 3 6 6 5 0 Bacterial protein of unknown function (DUF883) ApoL PF05461.11 EMD69689.1 - 9.5 5.4 11.0 5.5 6.2 0.1 3.2 4 0 0 4 4 4 0 Apolipoprotein L HAD_2 PF13419.6 EMD69690.1 - 6.2e-26 91.6 0.0 8.4e-26 91.1 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EMD69690.1 - 5.6e-13 49.7 0.0 4.3e-12 46.8 0.0 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EMD69690.1 - 7.2e-06 26.0 0.0 1.6e-05 24.9 0.0 1.6 1 0 0 1 1 1 1 HAD-hyrolase-like HAD PF12710.7 EMD69690.1 - 4.7e-05 23.9 0.0 6.1e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 EMD69690.1 - 0.00029 20.9 0.0 0.0029 17.7 0.0 2.2 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase NIF PF03031.18 EMD69690.1 - 0.12 12.1 0.0 1.7 8.4 0.0 2.2 1 1 0 1 1 1 0 NLI interacting factor-like phosphatase Peptidase_M28 PF04389.17 EMD69692.1 - 1e-34 120.0 0.0 1.6e-34 119.4 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 EMD69692.1 - 6.9e-12 45.2 1.6 1.1e-11 44.6 0.5 1.9 2 0 0 2 2 2 1 PA domain Peptidase_M20 PF01546.28 EMD69692.1 - 0.00016 21.5 0.1 0.00099 18.9 0.0 2.2 2 1 0 2 2 2 1 Peptidase family M20/M25/M40 PHD PF00628.29 EMD69694.1 - 0.0056 16.5 6.9 0.0056 16.5 6.9 3.7 3 1 1 4 4 4 2 PHD-finger zf-RING_2 PF13639.6 EMD69694.1 - 0.029 14.7 5.5 0.029 14.7 5.5 4.8 3 2 1 4 4 4 0 Ring finger domain FAP PF07174.11 EMD69694.1 - 5.2 6.4 9.6 9.8 5.5 9.6 1.3 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) FAD_binding_3 PF01494.19 EMD69695.1 - 1.2e-11 44.5 1.3 2.8e-07 30.1 0.0 2.8 2 1 0 2 2 2 2 FAD binding domain NAD_binding_9 PF13454.6 EMD69695.1 - 0.00023 21.2 0.1 0.1 12.6 0.3 2.7 3 0 0 3 3 3 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 EMD69695.1 - 0.00025 21.2 0.5 0.00059 20.0 0.5 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain SE PF08491.10 EMD69695.1 - 0.00033 19.8 0.0 0.0027 16.8 0.0 2.1 2 0 0 2 2 2 1 Squalene epoxidase DAO PF01266.24 EMD69695.1 - 0.00054 19.6 1.7 0.0014 18.3 1.6 1.7 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EMD69695.1 - 0.0024 17.1 0.7 0.014 14.7 0.7 1.9 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EMD69695.1 - 0.0069 15.5 0.1 0.053 12.6 0.2 2.0 2 0 0 2 2 2 1 Lycopene cyclase protein Thi4 PF01946.17 EMD69695.1 - 0.015 14.5 0.6 0.025 13.8 0.6 1.2 1 0 0 1 1 1 0 Thi4 family Trp_halogenase PF04820.14 EMD69695.1 - 0.052 12.4 2.6 0.067 12.0 0.8 1.8 2 0 0 2 2 2 0 Tryptophan halogenase FAD_binding_2 PF00890.24 EMD69695.1 - 0.12 11.4 0.2 0.19 10.8 0.2 1.3 1 0 0 1 1 1 0 FAD binding domain HI0933_like PF03486.14 EMD69695.1 - 0.14 10.9 0.8 0.2 10.3 0.8 1.2 1 0 0 1 1 1 0 HI0933-like protein MFS_1 PF07690.16 EMD69697.1 - 9.9e-23 80.6 30.6 2.3e-21 76.1 30.6 2.0 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF1772 PF08592.11 EMD69697.1 - 6.5 7.1 10.5 38 4.6 1.1 3.8 3 1 0 3 3 3 0 Domain of unknown function (DUF1772) AA_permease_2 PF13520.6 EMD69698.1 - 1.6e-77 261.1 28.9 2e-77 260.8 28.9 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 EMD69698.1 - 1.1e-17 63.9 25.2 1.6e-17 63.3 25.2 1.2 1 0 0 1 1 1 1 Amino acid permease Pectinesterase PF01095.19 EMD69699.1 - 1.2e-27 96.4 0.1 4.7e-24 84.6 0.2 2.1 2 0 0 2 2 2 2 Pectinesterase p450 PF00067.22 EMD69700.1 - 3.4e-64 217.3 0.0 4.2e-64 217.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 DUF3655 PF12379.8 EMD69700.1 - 0.1 12.9 0.0 0.27 11.6 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3655) Glyco_hydro_16 PF00722.21 EMD69701.1 - 3.6e-38 130.8 2.1 5.6e-38 130.2 2.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 Chitin_bind_1 PF00187.19 EMD69701.1 - 0.35 11.4 11.1 0.98 9.9 11.1 1.7 1 0 0 1 1 1 0 Chitin recognition protein DSPc PF00782.20 EMD69702.1 - 4.1e-21 75.2 0.0 3.3e-15 56.1 0.0 2.1 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain DSPn PF14671.6 EMD69702.1 - 0.048 14.1 0.0 0.085 13.3 0.0 1.3 1 0 0 1 1 1 0 Dual specificity protein phosphatase, N-terminal half Peptidase_S28 PF05577.12 EMD69703.1 - 5.5e-53 180.3 1.5 8.2e-53 179.7 1.5 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase S28 CorA PF01544.18 EMD69704.1 - 2.7e-07 30.2 10.0 5.7e-06 25.9 10.0 2.3 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein PNP_UDP_1 PF01048.20 EMD69705.1 - 8.6e-11 41.5 1.6 2.3e-10 40.2 1.6 1.7 1 1 0 1 1 1 1 Phosphorylase superfamily Ank_2 PF12796.7 EMD69706.1 - 2.7e-13 50.3 0.0 6.4e-07 29.9 0.0 4.1 2 1 2 4 4 4 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMD69706.1 - 5.5e-09 36.4 0.3 0.011 16.4 0.0 4.4 3 1 2 5 5 5 2 Ankyrin repeats (many copies) AAA_16 PF13191.6 EMD69706.1 - 3.8e-06 27.4 0.1 0.00057 20.3 0.0 2.6 2 0 0 2 2 2 1 AAA ATPase domain Ank_3 PF13606.6 EMD69706.1 - 7.1e-06 26.0 0.1 2.8 8.8 0.0 5.4 5 0 0 5 5 4 1 Ankyrin repeat NACHT PF05729.12 EMD69706.1 - 9.5e-06 25.6 0.7 4.7e-05 23.4 0.1 2.4 2 0 0 2 2 2 1 NACHT domain Ank PF00023.30 EMD69706.1 - 2.3e-05 24.6 0.3 9.3 6.9 0.0 4.7 4 0 0 4 4 4 1 Ankyrin repeat AAA_22 PF13401.6 EMD69706.1 - 5.7e-05 23.4 0.0 0.00032 21.0 0.0 2.3 1 1 1 2 2 2 1 AAA domain Ank_5 PF13857.6 EMD69706.1 - 0.0044 17.3 0.0 0.2 12.0 0.0 3.3 2 1 1 3 3 3 1 Ankyrin repeats (many copies) ATPase_2 PF01637.18 EMD69706.1 - 0.032 14.1 0.0 0.072 13.0 0.0 1.5 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea KAP_NTPase PF07693.14 EMD69706.1 - 0.051 12.8 3.1 0.086 12.1 0.3 2.1 1 1 0 2 2 2 0 KAP family P-loop domain AAA_29 PF13555.6 EMD69706.1 - 0.1 12.4 0.0 0.4 10.5 0.0 2.0 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_30 PF13604.6 EMD69706.1 - 0.14 11.9 0.1 0.26 11.0 0.1 1.4 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EMD69706.1 - 0.22 12.0 0.7 0.93 10.0 0.0 2.3 3 0 0 3 3 3 0 ABC transporter Fungal_trans PF04082.18 EMD69707.1 - 1.4e-11 43.9 0.0 3.9e-11 42.5 0.0 1.7 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD69707.1 - 1.5e-06 28.2 11.0 2.5e-06 27.5 11.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CGI-121 PF08617.10 EMD69708.1 - 1.9e-53 180.9 0.1 2.3e-53 180.7 0.1 1.0 1 0 0 1 1 1 1 Kinase binding protein CGI-121 COX5B PF01215.19 EMD69709.1 - 8.7e-56 187.1 0.0 1.3e-55 186.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Vb Isochorismatase PF00857.20 EMD69710.1 - 3.3e-31 108.8 0.1 9e-31 107.4 0.1 1.7 1 1 0 1 1 1 1 Isochorismatase family Oxysterol_BP PF01237.18 EMD69711.1 - 1.3e-91 307.2 0.0 1.1e-89 301.0 0.0 2.2 1 1 0 1 1 1 1 Oxysterol-binding protein Myb_DNA-bind_6 PF13921.6 EMD69715.1 - 3e-14 53.0 0.6 2.2e-07 31.0 0.0 2.7 2 1 1 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 EMD69715.1 - 1.6e-11 44.2 0.1 6.5e-05 23.0 0.0 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain SUIM_assoc PF16619.5 EMD69715.1 - 0.00039 20.4 6.9 0.00039 20.4 6.9 2.5 2 1 0 2 2 2 1 Unstructured region C-term to UIM in Ataxin3 DUF3646 PF12362.8 EMD69715.1 - 0.016 15.6 0.1 0.58 10.5 0.0 2.6 2 1 0 2 2 2 0 DNA polymerase III gamma and tau subunits C terminal SANT_DAMP1_like PF16282.5 EMD69715.1 - 0.077 13.2 1.2 2 8.7 0.3 2.3 1 1 1 2 2 2 0 SANT/Myb-like domain of DAMP1 DUF4407 PF14362.6 EMD69715.1 - 1.2 8.4 6.3 1.6 8.0 6.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Spt20 PF12090.8 EMD69715.1 - 2.6 7.6 18.4 5.4 6.6 18.4 1.5 1 0 0 1 1 1 0 Spt20 family PKI PF02827.16 EMD69715.1 - 5.2 7.4 7.4 8.3 6.7 6.5 1.9 2 0 0 2 2 2 0 cAMP-dependent protein kinase inhibitor Roughex PF06020.11 EMD69715.1 - 9 5.3 12.1 14 4.7 12.1 1.2 1 0 0 1 1 1 0 Drosophila roughex protein Presenilin PF01080.17 EMD69715.1 - 9.9 4.8 6.9 13 4.4 6.9 1.1 1 0 0 1 1 1 0 Presenilin Myb_DNA-binding PF00249.31 EMD69716.1 - 2.8e-15 56.2 1.2 9.5e-09 35.3 0.3 2.2 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EMD69716.1 - 2.4e-09 37.3 0.3 8.9e-06 25.9 0.1 2.5 1 1 1 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 EMD69716.1 - 0.087 12.7 0.3 0.14 12.1 0.3 1.3 1 0 0 1 1 1 0 Myb DNA-binding like SP_C-Propep PF08999.10 EMD69717.1 - 0.0013 18.5 9.8 0.002 17.9 8.7 1.8 2 0 0 2 2 2 1 Surfactant protein C, N terminal propeptide DUF3357 PF11837.8 EMD69717.1 - 0.13 12.7 1.3 0.33 11.4 1.3 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3357) Renin_r PF07850.14 EMD69717.1 - 0.14 12.8 2.0 0.25 11.9 2.0 1.4 1 0 0 1 1 1 0 Renin receptor-like protein EphA2_TM PF14575.6 EMD69717.1 - 0.21 12.5 2.3 0.55 11.1 2.3 1.8 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Shisa PF13908.6 EMD69717.1 - 0.55 10.4 7.7 0.53 10.5 2.5 2.2 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator ECSCR PF15820.5 EMD69717.1 - 7.7 6.4 9.2 18 5.2 9.2 1.6 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator DUF1218 PF06749.12 EMD69717.1 - 8 7.1 13.7 4.4 7.9 1.5 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1218) Myb_DNA-bind_6 PF13921.6 EMD69718.1 - 1.6e-05 25.0 0.0 0.0055 16.9 0.2 2.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 EMD69718.1 - 0.00044 20.4 0.9 0.00078 19.6 0.3 1.8 2 0 0 2 2 2 1 Myb-like DNA-binding domain ATPase_gene1 PF09527.10 EMD69719.1 - 0.016 15.4 0.9 0.023 14.8 0.6 1.5 1 1 0 1 1 1 0 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter RhgB_N PF09284.10 EMD69719.1 - 0.072 12.6 0.1 0.079 12.5 0.1 1.1 1 0 0 1 1 1 0 Rhamnogalacturonan lyase B, N-terminal TrkH PF02386.16 EMD69720.1 - 3.1e-94 316.2 2.6 8.1e-93 311.5 0.5 2.4 2 1 0 2 2 2 2 Cation transport protein MFS_1 PF07690.16 EMD69721.1 - 1.7e-31 109.4 28.1 3.2e-21 75.7 5.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EMD69721.1 - 2.8e-09 36.3 0.9 2.8e-09 36.3 0.9 2.4 2 1 0 2 2 2 1 Sugar (and other) transporter MFS_1_like PF12832.7 EMD69721.1 - 0.38 9.6 10.0 0.95 8.3 1.4 2.4 2 0 0 2 2 2 0 MFS_1 like family GPI-anchored PF10342.9 EMD69723.1 - 9.2e-20 71.2 0.1 1.5e-19 70.5 0.1 1.3 1 0 0 1 1 1 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family SAP130_C PF16014.5 EMD69723.1 - 1.5 7.8 10.3 2 7.4 10.3 1.2 1 0 0 1 1 1 0 Histone deacetylase complex subunit SAP130 C-terminus Cellulase PF00150.18 EMD69724.1 - 3.4e-14 52.9 0.1 3.4e-14 52.9 0.1 1.8 2 1 0 2 2 2 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_42 PF02449.15 EMD69724.1 - 0.00053 19.4 0.1 0.05 12.9 0.2 2.2 1 1 1 2 2 2 2 Beta-galactosidase Glyco_hydro_53 PF07745.13 EMD69724.1 - 0.0045 16.0 0.1 0.0072 15.4 0.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 53 TENA_THI-4 PF03070.16 EMD69725.1 - 0.023 14.5 0.0 0.048 13.5 0.0 1.5 1 1 0 1 1 1 0 TENA/THI-4/PQQC family zf-BED PF02892.15 EMD69725.1 - 0.066 13.3 4.0 0.066 13.2 1.6 2.2 2 0 0 2 2 2 0 BED zinc finger PNP_UDP_1 PF01048.20 EMD69726.1 - 8.6e-10 38.3 0.3 1.8e-09 37.2 0.3 1.6 1 0 0 1 1 1 1 Phosphorylase superfamily AAA_22 PF13401.6 EMD69726.1 - 4.5e-05 23.7 0.1 0.0009 19.5 0.0 2.6 2 1 0 2 2 2 1 AAA domain NACHT PF05729.12 EMD69726.1 - 4.9e-05 23.3 0.2 0.00017 21.5 0.1 1.9 2 0 0 2 2 2 1 NACHT domain KAP_NTPase PF07693.14 EMD69726.1 - 0.00042 19.7 2.4 0.0013 18.0 0.2 2.2 1 1 0 2 2 2 1 KAP family P-loop domain AAA_16 PF13191.6 EMD69726.1 - 0.00092 19.6 0.3 0.027 14.8 0.0 2.7 2 1 0 2 2 2 1 AAA ATPase domain AAA_30 PF13604.6 EMD69726.1 - 0.029 14.1 0.0 0.067 12.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EMD69726.1 - 0.06 13.7 0.0 0.64 10.4 0.0 2.5 2 0 0 2 2 2 0 RNA helicase AAA_29 PF13555.6 EMD69726.1 - 0.13 12.0 0.1 0.4 10.5 0.1 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain Ank_4 PF13637.6 EMD69727.1 - 5.4e-24 84.2 3.5 1.9e-09 37.9 0.0 3.9 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 EMD69727.1 - 5.5e-22 78.2 3.9 7.2e-12 45.7 0.3 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 EMD69727.1 - 1.5e-18 66.3 7.6 5.1e-05 23.5 0.0 4.1 4 0 0 4 4 4 3 Ankyrin repeat Ank_3 PF13606.6 EMD69727.1 - 7.9e-12 44.3 0.7 0.096 13.3 0.0 4.1 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 EMD69727.1 - 3.1e-08 33.7 1.1 0.0013 19.0 0.1 3.1 1 1 2 3 3 3 3 Ankyrin repeats (many copies) YajC PF02699.15 EMD69727.1 - 0.047 13.6 1.5 4.5 7.2 0.1 2.8 1 1 2 3 3 3 0 Preprotein translocase subunit ECSCR PF15820.5 EMD69727.1 - 0.051 13.4 0.0 10 6.0 0.0 2.6 1 1 2 3 3 3 0 Endothelial cell-specific chemotaxis regulator ApbA PF02558.16 EMD69727.1 - 0.34 10.6 6.3 3.8 7.1 0.4 2.9 1 1 2 3 3 3 0 Ketopantoate reductase PanE/ApbA MT0933_antitox PF14013.6 EMD69727.1 - 0.69 10.3 5.1 52 4.3 0.7 3.2 1 1 1 2 2 2 0 MT0933-like antitoxin protein HET PF06985.11 EMD69728.1 - 2.3e-23 83.1 0.0 3.5e-23 82.6 0.0 1.3 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Sugar_tr PF00083.24 EMD69729.1 - 1.3e-84 284.7 26.3 1.6e-84 284.4 26.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD69729.1 - 7.4e-14 51.4 31.3 7.4e-14 51.4 31.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily VIT1 PF01988.19 EMD69729.1 - 0.017 15.0 1.0 0.35 10.7 0.0 2.6 2 0 0 2 2 2 0 VIT family SAGA-Tad1 PF12767.7 EMD69730.1 - 0.0012 18.7 0.0 0.0022 17.8 0.0 1.4 1 1 0 1 1 1 1 Transcriptional regulator of RNA polII, SAGA, subunit AAA PF00004.29 EMD69732.1 - 1.3e-17 64.4 0.0 3e-17 63.3 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EMD69732.1 - 0.00015 22.1 3.3 0.033 14.5 0.1 2.8 2 1 1 3 3 3 2 AAA domain RuvB_N PF05496.12 EMD69732.1 - 0.00043 20.1 0.0 0.00096 18.9 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EMD69732.1 - 0.0042 17.5 0.5 0.018 15.4 0.2 2.2 2 1 0 2 2 2 1 AAA ATPase domain AAA_18 PF13238.6 EMD69732.1 - 0.0081 16.7 0.0 0.062 13.9 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EMD69732.1 - 0.0088 16.2 0.0 0.032 14.4 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 EMD69732.1 - 0.011 15.7 0.0 0.034 14.2 0.0 1.8 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_17 PF13207.6 EMD69732.1 - 0.013 16.0 0.0 0.041 14.3 0.0 2.0 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 EMD69732.1 - 0.043 13.0 0.1 9.3 5.3 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain ATPase PF06745.13 EMD69732.1 - 0.056 12.8 0.3 0.63 9.3 0.2 2.2 1 1 1 2 2 2 0 KaiC AAA_7 PF12775.7 EMD69732.1 - 0.071 12.6 0.0 0.14 11.6 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region DUF3486 PF11985.8 EMD69732.1 - 0.53 10.7 2.4 3.7 7.9 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3486) AIRS_C PF02769.22 EMD69733.1 - 3.1e-35 121.6 0.0 6.8e-35 120.5 0.0 1.6 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain AIRS PF00586.24 EMD69733.1 - 3.1e-13 50.2 1.0 9e-13 48.7 1.0 1.8 1 0 0 1 1 1 1 AIR synthase related protein, N-terminal domain GHMP_kinases_N PF00288.26 EMD69733.1 - 6.4e-13 48.7 0.1 1.7e-12 47.4 0.1 1.8 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 EMD69733.1 - 0.0026 18.1 0.0 0.012 15.9 0.0 2.1 2 0 0 2 2 2 1 GHMP kinases C terminal Pribosyltran PF00156.27 EMD69734.1 - 6.1e-15 55.1 0.0 1e-14 54.3 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 EMD69734.1 - 0.0096 15.4 0.0 0.014 14.9 0.0 1.2 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Ribonuc_L-PSP PF01042.21 EMD69735.1 - 2.9e-39 133.8 0.0 3.3e-39 133.6 0.0 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP p450 PF00067.22 EMD69736.1 - 9.7e-58 196.0 0.0 1.3e-57 195.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Gag_p10 PF02337.17 EMD69736.1 - 0.092 12.7 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 Retroviral GAG p10 protein Peptidase_S9 PF00326.21 EMD69737.1 - 2.3e-45 154.7 1.1 3.3e-45 154.2 1.1 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family PD40 PF07676.12 EMD69737.1 - 0.0044 16.9 1.4 0.17 11.9 0.0 4.0 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat TRP PF06011.12 EMD69738.1 - 5.5e-43 147.3 25.2 9.6e-41 139.9 25.2 2.1 1 1 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.6 EMD69738.1 - 2.5e-22 79.8 0.1 4e-22 79.1 0.1 1.3 1 0 0 1 1 1 1 ML-like domain FYVE PF01363.21 EMD69739.1 - 2.2e-21 75.8 0.6 2.2e-21 75.8 0.6 2.8 3 0 0 3 3 3 1 FYVE zinc finger zf-RING_2 PF13639.6 EMD69739.1 - 9.8e-08 32.2 22.5 2.6e-07 30.9 3.3 3.5 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4_2 PF13923.6 EMD69739.1 - 5.3e-05 23.0 2.1 5.3e-05 23.0 2.1 3.7 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EMD69739.1 - 0.0005 19.8 9.1 0.00064 19.4 4.0 3.0 3 0 0 3 3 3 1 RING-like zinc finger Rad50_zn_hook PF04423.14 EMD69739.1 - 0.00058 19.7 3.4 0.56 10.1 0.1 2.4 2 0 0 2 2 2 2 Rad50 zinc hook motif FYVE_2 PF02318.16 EMD69739.1 - 0.0059 16.8 1.3 0.0059 16.8 1.3 2.0 2 0 0 2 2 2 1 FYVE-type zinc finger zf-C3HC4 PF00097.25 EMD69739.1 - 0.016 15.0 1.4 0.016 15.0 1.4 3.6 4 1 0 4 4 4 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EMD69739.1 - 0.029 14.4 1.8 0.029 14.4 1.8 3.7 3 0 0 3 3 3 0 RING-type zinc-finger zf-B_box PF00643.24 EMD69739.1 - 7 6.9 10.2 2 8.6 4.7 2.9 2 0 0 2 2 2 0 B-box zinc finger FANCL_C PF11793.8 EMD69739.1 - 9 6.6 11.4 0.6 10.3 2.7 2.9 3 0 0 3 3 3 0 FANCL C-terminal domain Glyco_hydro_18 PF00704.28 EMD69740.1 - 6.9e-28 98.3 0.0 1.4e-27 97.2 0.0 1.6 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 Abhydrolase_2 PF02230.16 EMD69741.1 - 0.0038 17.1 0.0 0.0054 16.6 0.0 1.1 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.21 EMD69741.1 - 0.071 12.6 0.0 0.11 12.0 0.0 1.2 1 0 0 1 1 1 0 Prolyl oligopeptidase family MazG-like PF12643.7 EMD69741.1 - 0.11 12.7 0.0 0.22 11.8 0.0 1.4 1 0 0 1 1 1 0 MazG-like family NAS PF03059.16 EMD69742.1 - 4.9e-68 229.5 0.0 5.9e-68 229.2 0.0 1.0 1 0 0 1 1 1 1 Nicotianamine synthase protein Methyltransf_31 PF13847.6 EMD69742.1 - 3e-08 33.6 0.0 5e-08 32.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Amidohydro_3 PF07969.11 EMD69743.1 - 7.1e-69 233.5 0.0 8.9e-69 233.2 0.0 1.0 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_1 PF01979.20 EMD69743.1 - 1.4e-09 37.8 0.0 5.5e-09 35.8 0.0 2.0 2 0 0 2 2 2 1 Amidohydrolase family CorA PF01544.18 EMD69744.1 - 1.7e-10 40.7 2.1 2.9e-10 40.0 0.2 2.2 2 0 0 2 2 2 1 CorA-like Mg2+ transporter protein DUF2207 PF09972.9 EMD69744.1 - 0.07 11.9 0.1 0.1 11.3 0.1 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF1651 PF07864.11 EMD69744.1 - 0.074 13.4 0.8 0.47 10.8 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1651) mRNA_stabil PF13929.6 EMD69744.1 - 0.078 12.0 0.3 0.14 11.1 0.3 1.3 1 0 0 1 1 1 0 mRNA stabilisation Bap31_Bap29_C PF18035.1 EMD69744.1 - 0.16 12.0 0.5 0.76 9.8 0.0 2.3 2 0 0 2 2 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain Fungal_TACC PF12709.7 EMD69744.1 - 0.82 10.2 3.7 0.64 10.5 0.3 2.3 2 0 0 2 2 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins GMC_oxred_N PF00732.19 EMD69746.1 - 1.9e-62 211.3 0.0 2.5e-62 210.9 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EMD69746.1 - 5.4e-29 101.6 0.0 1.4e-28 100.2 0.0 1.8 2 0 0 2 2 2 1 GMC oxidoreductase DAO PF01266.24 EMD69746.1 - 4e-06 26.7 0.1 0.00014 21.5 0.0 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EMD69746.1 - 1.7e-05 24.1 0.2 0.14 11.2 0.0 2.3 2 0 0 2 2 2 2 FAD binding domain Pyr_redox_2 PF07992.14 EMD69746.1 - 5.3e-05 22.6 0.1 0.034 13.4 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EMD69746.1 - 0.00014 22.0 0.4 0.00048 20.3 0.1 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 EMD69746.1 - 0.0002 20.7 0.1 0.19 11.0 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EMD69746.1 - 0.00072 18.7 0.1 0.0014 17.7 0.1 1.5 1 0 0 1 1 1 1 Lycopene cyclase protein HI0933_like PF03486.14 EMD69746.1 - 0.035 12.8 0.0 0.23 10.1 0.0 2.0 2 0 0 2 2 2 0 HI0933-like protein Pyr_redox PF00070.27 EMD69746.1 - 0.036 14.6 0.3 0.1 13.2 0.1 1.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EMD69746.1 - 0.039 13.9 0.0 0.088 12.8 0.0 1.6 1 0 0 1 1 1 0 FAD-NAD(P)-binding TrkA_N PF02254.18 EMD69746.1 - 0.1 12.9 0.0 0.21 11.8 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain eRF1_1 PF03463.15 EMD69747.1 - 8.8e-49 164.8 0.3 1.4e-48 164.1 0.3 1.3 1 0 0 1 1 1 1 eRF1 domain 1 eRF1_2 PF03464.15 EMD69747.1 - 1e-15 58.3 0.0 1.9e-15 57.4 0.0 1.5 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 EMD69747.1 - 2.5e-14 53.7 0.0 4.7e-14 52.8 0.0 1.5 1 0 0 1 1 1 1 eRF1 domain 3 DUF3667 PF12412.8 EMD69747.1 - 0.19 11.3 0.1 0.44 10.1 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3667) MOZART1 PF12554.8 EMD69748.1 - 3.3e-23 81.2 0.6 3.9e-23 81.0 0.6 1.1 1 0 0 1 1 1 1 Mitotic-spindle organizing gamma-tubulin ring associated DnaB_bind PF10410.9 EMD69748.1 - 0.15 12.3 0.6 4.9 7.4 0.2 2.2 2 0 0 2 2 2 0 DnaB-helicase binding domain of primase Acetyltransf_1 PF00583.25 EMD69749.1 - 6.2e-08 32.9 0.1 1.3e-07 31.9 0.1 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EMD69749.1 - 0.015 15.8 0.1 0.12 12.8 0.0 2.1 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Pho86 PF11124.8 EMD69749.1 - 0.027 13.9 0.3 0.04 13.4 0.3 1.2 1 0 0 1 1 1 0 Inorganic phosphate transporter Pho86 Pkinase PF00069.25 EMD69751.1 - 1.1e-49 169.2 0.0 2.2e-49 168.2 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD69751.1 - 3.3e-23 82.3 0.0 6.9e-23 81.2 0.0 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase SAB PF04382.13 EMD69751.1 - 0.0005 20.1 0.3 0.0015 18.5 0.3 1.8 1 0 0 1 1 1 1 SAB domain APH PF01636.23 EMD69751.1 - 0.0035 17.3 0.0 0.0076 16.2 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.6 EMD69751.1 - 0.0059 16.0 0.1 0.066 12.5 0.1 2.2 1 1 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 EMD69751.1 - 0.013 14.4 0.0 0.031 13.2 0.0 1.5 1 0 0 1 1 1 0 Haspin like kinase domain FTA2 PF13095.6 EMD69751.1 - 0.051 13.2 0.1 11 5.6 0.0 2.3 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Svf1_C PF17187.4 EMD69752.1 - 4.2e-60 202.3 0.1 6e-60 201.8 0.1 1.2 1 0 0 1 1 1 1 Svf1-like C-terminal lipocalin-like domain Svf1 PF08622.10 EMD69752.1 - 2.1e-51 174.2 0.0 3e-51 173.7 0.0 1.2 1 0 0 1 1 1 1 Svf1-like N-terminal lipocalin domain CrtC PF07143.11 EMD69752.1 - 0.037 14.7 0.0 0.073 13.7 0.0 1.4 1 0 0 1 1 1 0 CrtC N-terminal lipocalin domain Mlh1_C PF16413.5 EMD69755.1 - 9.3e-98 326.9 0.0 1.6e-97 326.1 0.0 1.4 1 0 0 1 1 1 1 DNA mismatch repair protein Mlh1 C-terminus DNA_mis_repair PF01119.19 EMD69755.1 - 3.2e-34 117.2 0.0 5.3e-34 116.5 0.0 1.4 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 EMD69755.1 - 1.5e-13 50.7 0.0 3.7e-13 49.5 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 EMD69755.1 - 1.8e-07 31.6 0.0 4e-07 30.5 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Sin_N PF04801.13 EMD69756.1 - 3.9e-29 102.1 4.8 2e-28 99.8 4.8 1.9 1 1 0 1 1 1 1 Sin-like protein conserved region RNase_H_2 PF13482.6 EMD69756.1 - 0.041 13.9 0.4 0.068 13.2 0.4 1.3 1 0 0 1 1 1 0 RNase_H superfamily MMS1_N PF10433.9 EMD69757.1 - 4.9e-135 450.9 0.0 7.5e-135 450.3 0.0 1.3 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 EMD69757.1 - 7.9e-79 265.3 0.1 6.6e-77 259.0 0.0 2.9 2 1 1 3 3 3 1 CPSF A subunit region Ntox30 PF15532.6 EMD69757.1 - 0.1 13.0 0.0 0.32 11.4 0.0 1.8 2 0 0 2 2 2 0 Bacterial toxin 30 HPS3_N PF14761.6 EMD69757.1 - 0.16 11.5 1.3 6.7 6.2 0.2 3.8 3 1 1 4 4 4 0 Hermansky-Pudlak syndrome 3 RHS_repeat PF05593.14 EMD69757.1 - 0.39 11.3 2.1 48 4.6 0.0 4.0 4 0 0 4 4 4 0 RHS Repeat PAM2 PF07145.15 EMD69758.1 - 0.055 13.2 1.8 0.14 11.9 1.8 1.7 1 0 0 1 1 1 0 Ataxin-2 C-terminal region PPP4R2 PF09184.11 EMD69758.1 - 0.17 11.4 2.5 0.24 11.0 2.5 1.2 1 0 0 1 1 1 0 PPP4R2 EamA PF00892.20 EMD69759.1 - 0.001 19.2 22.8 0.0092 16.2 22.8 1.9 1 1 0 1 1 1 1 EamA-like transporter family TMEM234 PF10639.9 EMD69759.1 - 0.19 11.7 5.0 0.35 10.9 5.0 1.5 1 1 0 1 1 1 0 Putative transmembrane family 234 TFIIA_gamma_C PF02751.14 EMD69760.1 - 2.1e-25 88.6 2.6 3.7e-25 87.8 2.6 1.4 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit TFIIA_gamma_N PF02268.16 EMD69760.1 - 8.4e-23 80.1 0.1 1.2e-22 79.7 0.1 1.2 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit, helical domain MoCF_biosynth PF00994.24 EMD69761.1 - 2.9e-54 182.6 0.1 1e-28 99.8 0.0 2.3 2 0 0 2 2 2 2 Probable molybdopterin binding domain MoeA_N PF03453.17 EMD69761.1 - 2.1e-39 134.8 1.2 3.5e-39 134.1 1.2 1.4 1 0 0 1 1 1 1 MoeA N-terminal region (domain I and II) ATP-synt_C PF00137.21 EMD69761.1 - 2.8e-25 88.4 28.6 1.8e-15 57.0 9.6 2.7 2 0 0 2 2 2 2 ATP synthase subunit C MoeA_C PF03454.15 EMD69761.1 - 2.1e-17 63.0 0.4 5.1e-17 61.8 0.0 1.9 2 0 0 2 2 2 1 MoeA C-terminal region (domain IV) DUF3341 PF11821.8 EMD69761.1 - 2.1 8.0 3.8 5.3 6.7 0.1 3.2 4 0 0 4 4 4 0 Protein of unknown function (DUF3341) Oxidored_q2 PF00420.24 EMD69761.1 - 7.9 6.2 8.1 5.5 6.7 5.2 2.2 2 1 0 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L DUF1043 PF06295.12 EMD69763.1 - 0.0044 17.0 0.0 0.0077 16.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1043) Phage_holin_2_4 PF16082.5 EMD69763.1 - 0.019 14.7 0.1 0.043 13.5 0.1 1.6 1 0 0 1 1 1 0 Bacteriophage holin family, superfamily II-like BatD PF13584.6 EMD69763.1 - 0.1 11.4 0.0 0.13 11.1 0.0 1.1 1 0 0 1 1 1 0 Oxygen tolerance LapA_dom PF06305.11 EMD69763.1 - 0.12 12.2 0.1 0.32 10.8 0.1 1.7 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain I-set PF07679.16 EMD69763.1 - 0.2 11.7 0.6 0.39 10.8 0.1 1.7 2 0 0 2 2 2 0 Immunoglobulin I-set domain DUF1180 PF06679.12 EMD69763.1 - 0.32 11.4 1.8 0.83 10.1 1.8 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1180) SET PF00856.28 EMD69764.1 - 8.4e-15 55.6 0.1 4.2e-14 53.3 0.0 2.1 2 1 0 2 2 2 1 SET domain DUF1786 PF08735.10 EMD69764.1 - 0.097 11.9 0.0 0.15 11.3 0.0 1.3 1 0 0 1 1 1 0 Putative pyruvate format-lyase activating enzyme (DUF1786) TPR_14 PF13428.6 EMD69765.1 - 2.3e-11 43.5 21.7 3.3 8.8 0.0 11.7 9 3 3 12 12 12 2 Tetratricopeptide repeat Suf PF05843.14 EMD69765.1 - 3.6e-10 40.3 9.5 0.025 14.5 0.1 6.0 3 1 2 5 5 5 2 Suppressor of forked protein (Suf) TPR_15 PF13429.6 EMD69765.1 - 4.9e-08 32.5 4.3 0.00012 21.5 0.3 4.6 4 1 1 5 5 5 1 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 EMD69765.1 - 2.2e-06 27.7 14.5 0.23 11.5 0.1 7.2 6 1 0 6 6 6 2 Mad3/BUB1 homology region 1 TPR_8 PF13181.6 EMD69765.1 - 5.5e-06 26.2 10.0 0.019 15.1 0.0 7.1 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_19 PF14559.6 EMD69765.1 - 6.8e-06 26.5 0.6 11 6.6 0.0 5.8 5 1 0 6 6 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 EMD69765.1 - 8e-06 25.6 19.2 0.036 14.2 0.0 7.6 10 0 0 10 10 6 2 Tetratricopeptide repeat TPR_12 PF13424.6 EMD69765.1 - 0.00017 21.8 7.7 7.8 6.9 0.0 7.1 7 0 0 7 7 7 1 Tetratricopeptide repeat SNAP PF14938.6 EMD69765.1 - 0.00036 20.0 4.8 0.72 9.2 0.3 4.8 5 1 1 6 6 6 1 Soluble NSF attachment protein, SNAP TPR_6 PF13174.6 EMD69765.1 - 0.0011 19.5 3.4 18 6.2 0.0 6.7 7 0 0 7 7 6 0 Tetratricopeptide repeat RPN7 PF10602.9 EMD69765.1 - 0.0028 17.4 0.8 0.018 14.8 0.3 2.7 3 1 0 3 3 3 1 26S proteasome subunit RPN7 NRDE-2 PF08424.10 EMD69765.1 - 0.0038 16.4 11.3 0.019 14.1 0.2 4.9 3 3 0 4 4 4 1 NRDE-2, necessary for RNA interference HAT PF02184.16 EMD69765.1 - 0.011 15.7 2.3 2.9 7.9 0.0 5.4 5 0 0 5 5 5 0 HAT (Half-A-TPR) repeat TPR_7 PF13176.6 EMD69765.1 - 0.011 15.7 0.7 1 9.5 0.0 4.6 6 0 0 6 6 4 0 Tetratricopeptide repeat TPR_17 PF13431.6 EMD69765.1 - 0.029 14.7 4.0 5.9 7.5 0.0 5.1 6 0 0 6 6 4 0 Tetratricopeptide repeat CKAP2_C PF15297.6 EMD69765.1 - 0.052 12.6 0.5 0.16 11.0 0.5 1.8 1 0 0 1 1 1 0 Cytoskeleton-associated protein 2 C-terminus MIT PF04212.18 EMD69765.1 - 0.099 12.7 2.4 3.8 7.7 0.0 4.3 5 0 0 5 5 5 0 MIT (microtubule interacting and transport) domain APOBEC_C PF05240.14 EMD69765.1 - 0.2 11.6 2.0 0.53 10.3 0.1 2.6 2 0 0 2 2 2 0 APOBEC-like C-terminal domain TPR_10 PF13374.6 EMD69765.1 - 0.32 10.9 11.7 20 5.2 0.0 6.7 8 0 0 8 8 8 0 Tetratricopeptide repeat ATP-synt_D PF01813.17 EMD69766.1 - 1.1e-70 237.5 3.4 1.7e-70 236.8 3.4 1.3 1 0 0 1 1 1 1 ATP synthase subunit D HtrL_YibB PF09612.10 EMD69766.1 - 0.042 13.4 0.3 0.062 12.8 0.3 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (HtrL_YibB) CobA_CobO_BtuR PF02572.15 EMD69766.1 - 0.12 12.7 5.2 0.46 10.7 0.1 2.5 1 1 1 3 3 3 0 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP Mig-14 PF07395.11 EMD69766.1 - 0.29 10.5 4.5 0.33 10.3 0.2 2.2 2 0 0 2 2 2 0 Mig-14 Ribosomal_L6e PF01159.19 EMD69766.1 - 1.3 9.6 9.8 0.2 12.2 5.1 2.0 2 1 0 2 2 2 0 Ribosomal protein L6e Sec62 PF03839.16 EMD69766.1 - 2.2 7.7 4.9 4.1 6.9 4.9 1.4 1 0 0 1 1 1 0 Translocation protein Sec62 RRM_1 PF00076.22 EMD69767.1 - 8.2e-23 80.0 1.9 2.6e-10 40.0 0.3 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EMD69767.1 - 2.5e-05 24.1 0.0 0.23 11.4 0.0 2.2 2 0 0 2 2 2 2 Occluded RNA-recognition motif RRM_7 PF16367.5 EMD69767.1 - 0.0022 18.0 0.1 1.6 8.9 0.0 3.0 2 1 0 2 2 2 2 RNA recognition motif RRM_5 PF13893.6 EMD69767.1 - 0.003 17.2 0.1 0.0046 16.6 0.1 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Calcipressin PF04847.12 EMD69767.1 - 0.003 17.3 1.2 0.09 12.5 0.1 2.5 2 1 0 2 2 2 1 Calcipressin PHM7_cyt PF14703.6 EMD69767.1 - 0.0043 17.3 2.5 3.8 7.7 0.0 3.1 2 1 1 3 3 3 2 Cytosolic domain of 10TM putative phosphate transporter Peptidase_C8 PF03569.13 EMD69767.1 - 0.086 12.4 0.4 3.1 7.3 0.0 2.5 2 1 1 3 3 3 0 Peptidase family C8 Exostosin PF03016.15 EMD69767.1 - 0.11 11.6 0.0 0.15 11.2 0.0 1.2 1 0 0 1 1 1 0 Exostosin family MFS_1 PF07690.16 EMD69768.1 - 3.4e-44 151.2 24.0 6.6e-39 133.8 18.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EMD69768.1 - 8.4e-06 24.6 17.5 0.0047 15.5 1.0 2.3 2 0 0 2 2 2 2 MFS/sugar transport protein MFS_1_like PF12832.7 EMD69768.1 - 0.0017 17.3 12.3 0.12 11.2 1.0 3.7 3 1 1 4 4 4 2 MFS_1 like family OATP PF03137.20 EMD69768.1 - 0.031 12.6 1.1 1.1 7.5 1.1 2.6 1 1 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family KRTAP PF11759.8 EMD69769.1 - 7.1 7.3 10.9 24 5.6 11.0 1.9 1 1 0 1 1 1 0 Keratin-associated matrix Cu-oxidase PF00394.22 EMD69770.1 - 4.3e-31 108.2 0.0 1.5e-28 99.9 0.0 2.4 2 0 0 2 2 2 2 Multicopper oxidase Cu-oxidase_3 PF07732.15 EMD69770.1 - 1.3e-23 83.2 1.7 5.3e-23 81.3 0.2 2.7 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 EMD69770.1 - 4.4e-22 78.3 11.4 8.2e-21 74.2 1.6 3.5 3 1 0 3 3 3 2 Multicopper oxidase PAPS_reduct PF01507.19 EMD69773.1 - 1.3e-28 100.2 0.0 6.1e-19 68.7 0.0 2.5 1 1 1 2 2 2 2 Phosphoadenosine phosphosulfate reductase family DUF5472 PF17566.2 EMD69773.1 - 0.17 11.8 0.0 0.43 10.6 0.0 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5472) NIR_SIR PF01077.22 EMD69774.1 - 2.4e-54 183.1 0.0 1.1e-48 164.8 0.0 2.6 2 0 0 2 2 2 2 Nitrite and sulphite reductase 4Fe-4S domain NIR_SIR_ferr PF03460.17 EMD69774.1 - 1.1e-31 108.5 0.0 1.4e-15 56.8 0.0 2.9 2 0 0 2 2 2 2 Nitrite/Sulfite reductase ferredoxin-like half domain Flavodoxin_1 PF00258.25 EMD69774.1 - 3.5e-26 92.1 0.0 9.1e-26 90.8 0.0 1.8 1 0 0 1 1 1 1 Flavodoxin POR_N PF01855.19 EMD69774.1 - 5.3e-11 42.7 0.3 1.3e-10 41.4 0.3 1.6 1 0 0 1 1 1 1 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg TraF PF13728.6 EMD69774.1 - 0.031 14.1 0.0 0.066 13.0 0.0 1.4 1 0 0 1 1 1 0 F plasmid transfer operon protein PNP_phzG_C PF10590.9 EMD69775.1 - 1.2e-20 73.3 1.2 1.2e-20 73.3 1.2 2.2 3 0 0 3 3 3 1 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region Putative_PNPOx PF01243.20 EMD69775.1 - 1.3e-17 63.8 0.0 1.8e-17 63.3 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyridox_oxase_2 PF12766.7 EMD69775.1 - 0.016 15.8 0.1 0.032 14.8 0.1 1.5 1 1 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase Imm74 PF15603.6 EMD69775.1 - 0.042 14.0 0.2 0.35 11.1 0.2 2.1 2 0 0 2 2 2 0 Immunity protein 74 TPR_2 PF07719.17 EMD69776.1 - 7.4e-10 38.2 19.0 0.0013 18.7 0.0 6.6 8 0 0 8 8 6 3 Tetratricopeptide repeat TPR_16 PF13432.6 EMD69776.1 - 1.9e-08 34.8 9.1 0.65 10.7 0.0 7.3 6 1 0 6 6 6 2 Tetratricopeptide repeat TPR_19 PF14559.6 EMD69776.1 - 7.1e-08 32.9 11.4 0.0031 18.0 0.1 6.0 5 1 1 6 6 5 2 Tetratricopeptide repeat TPR_1 PF00515.28 EMD69776.1 - 1.1e-07 31.4 10.3 0.11 12.3 0.0 5.8 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_11 PF13414.6 EMD69776.1 - 1.1e-06 28.2 0.3 0.77 9.5 0.1 5.1 4 0 0 4 4 4 2 TPR repeat TPR_12 PF13424.6 EMD69776.1 - 3.6e-06 27.2 5.8 0.008 16.4 0.6 4.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 EMD69776.1 - 5.4e-06 26.8 13.3 2.5 9.1 0.0 7.4 8 1 0 8 8 7 1 Tetratricopeptide repeat TPR_7 PF13176.6 EMD69776.1 - 0.0045 16.9 5.4 15 5.9 0.1 5.7 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_8 PF13181.6 EMD69776.1 - 0.0048 17.0 8.3 6.7 7.2 0.0 5.7 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_17 PF13431.6 EMD69776.1 - 0.011 16.0 1.7 16 6.1 0.0 5.5 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_9 PF13371.6 EMD69776.1 - 0.024 14.8 3.2 25 5.1 0.1 4.8 4 1 1 5 5 5 0 Tetratricopeptide repeat HemY_N PF07219.13 EMD69776.1 - 0.17 12.1 0.3 24 5.2 0.0 3.2 3 0 0 3 3 3 0 HemY protein N-terminus TPR_4 PF07721.14 EMD69776.1 - 5.3 8.0 13.6 9.9 7.1 0.7 4.9 5 0 0 5 5 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 EMD69776.1 - 8 7.3 10.4 2.8e+02 2.5 0.0 6.3 7 0 0 7 7 6 0 Tetratricopeptide repeat TPR_10 PF13374.6 EMD69776.1 - 9 6.3 6.4 16 5.5 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat Oxysterol_BP PF01237.18 EMD69778.1 - 3.3e-52 177.6 0.0 1e-45 156.2 0.0 2.2 1 1 1 2 2 2 2 Oxysterol-binding protein DUF5028 PF16431.5 EMD69778.1 - 0.2 11.6 0.0 0.34 10.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5028) SOG2 PF10428.9 EMD69778.1 - 5 6.2 8.5 9.8 5.2 8.5 1.4 1 1 0 1 1 1 0 RAM signalling pathway protein FAM60A PF15396.6 EMD69778.1 - 6.9 6.6 6.1 18 5.2 6.1 1.8 1 1 0 1 1 1 0 Protein Family FAM60A PAP2 PF01569.21 EMD69779.1 - 5.4e-19 68.3 4.5 5.4e-19 68.3 4.5 2.3 1 1 0 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.6 EMD69779.1 - 7.8e-06 25.7 4.4 1.3e-05 25.0 0.6 2.7 2 0 0 2 2 2 1 PAP2 superfamily Ras PF00071.22 EMD69780.1 - 2.9e-48 163.5 0.0 3.9e-48 163.1 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMD69780.1 - 1e-19 70.9 0.0 1.6e-19 70.3 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMD69780.1 - 7.9e-06 25.4 0.0 1.8e-05 24.2 0.0 1.5 1 1 0 1 1 1 1 ADP-ribosylation factor family AAA_24 PF13479.6 EMD69780.1 - 0.11 12.2 0.5 13 5.4 0.1 2.2 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 EMD69780.1 - 0.15 11.5 0.0 0.3 10.6 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region DASH_Dad1 PF08649.10 EMD69781.1 - 4.7e-25 87.5 1.5 5.8e-25 87.2 1.5 1.1 1 0 0 1 1 1 1 DASH complex subunit Dad1 DASH_Dad4 PF08650.10 EMD69781.1 - 0.0014 18.6 1.3 0.0019 18.1 1.3 1.2 1 0 0 1 1 1 1 DASH complex subunit Dad4 V_ATPase_I PF01496.19 EMD69781.1 - 0.12 10.3 1.5 0.12 10.2 1.5 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family tRNA_int_endo PF01974.17 EMD69782.1 - 5.6e-11 42.4 0.0 1.4e-10 41.1 0.0 1.6 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain MscS_TM PF12794.7 EMD69782.1 - 0.16 10.8 1.2 0.22 10.3 1.2 1.1 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 Wyosine_form PF08608.12 EMD69783.1 - 4.1e-23 81.5 0.0 9.8e-23 80.3 0.0 1.7 1 0 0 1 1 1 1 Wyosine base formation Radical_SAM PF04055.21 EMD69783.1 - 4.3e-20 72.8 0.0 1.2e-19 71.3 0.0 1.8 1 1 0 1 1 1 1 Radical SAM superfamily Flavodoxin_1 PF00258.25 EMD69783.1 - 3.3e-10 40.3 0.2 3.5e-09 37.0 0.2 2.4 1 1 0 1 1 1 1 Flavodoxin ADH_zinc_N PF00107.26 EMD69785.1 - 7.1e-28 97.2 0.4 1.1e-27 96.5 0.4 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EMD69785.1 - 2.2e-14 54.7 0.0 4.5e-14 53.6 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EMD69785.1 - 9.6e-12 44.8 0.3 4.7e-11 42.5 0.0 2.3 2 1 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain TrkA_N PF02254.18 EMD69785.1 - 0.00085 19.6 0.0 0.0019 18.5 0.0 1.6 1 0 0 1 1 1 1 TrkA-N domain PALP PF00291.25 EMD69785.1 - 0.028 13.8 0.6 0.055 12.9 0.6 1.5 1 0 0 1 1 1 0 Pyridoxal-phosphate dependent enzyme Peptidase_C48 PF02902.19 EMD69786.1 - 8.1e-17 61.8 0.0 1.5e-16 60.9 0.0 1.4 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain Metallophos PF00149.28 EMD69787.1 - 3.6e-38 132.1 0.5 5.9e-38 131.4 0.5 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EMD69787.1 - 0.014 15.8 0.0 0.028 14.8 0.0 1.5 1 0 0 1 1 1 0 Serine-threonine protein phosphatase N-terminal domain Cu_bind_like PF02298.17 EMD69789.1 - 0.023 14.7 0.2 0.052 13.6 0.2 1.5 1 1 0 1 1 1 0 Plastocyanin-like domain FAP PF07174.11 EMD69789.1 - 5.8 6.3 36.8 14 5.0 36.8 1.7 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) Sec7 PF01369.20 EMD69790.1 - 8.4e-68 227.7 0.1 1.3e-67 227.0 0.1 1.3 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.7 EMD69790.1 - 2.3e-17 63.3 0.2 1.4e-16 60.8 0.0 2.5 3 0 0 3 3 3 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DCB PF16213.5 EMD69790.1 - 0.00017 21.3 0.6 0.0014 18.3 0.3 2.5 2 0 0 2 2 2 1 Dimerisation and cyclophilin-binding domain of Mon2 SPEG_u2 PF16650.5 EMD69790.1 - 0.031 14.5 0.3 0.12 12.6 0.3 2.0 1 0 0 1 1 1 0 Unstructured region on SPEG complex protein Anp1 PF03452.14 EMD69791.1 - 2.2e-113 378.1 0.0 4.6e-113 377.0 0.0 1.5 1 0 0 1 1 1 1 Anp1 Tox-ODYAM1 PF15642.6 EMD69791.1 - 0.68 8.8 8.0 1.1 8.2 8.0 1.2 1 0 0 1 1 1 0 Toxin in Odyssella and Amoebophilus SspB PF04386.13 EMD69791.1 - 0.83 9.5 7.4 2 8.3 7.4 1.6 1 0 0 1 1 1 0 Stringent starvation protein B Smg8_Smg9 PF10220.9 EMD69791.1 - 4 5.6 9.3 4.8 5.4 9.3 1.1 1 0 0 1 1 1 0 Smg8_Smg9 AAA_11 PF13086.6 EMD69791.1 - 5.8 6.6 11.4 24 4.6 11.0 2.0 2 0 0 2 2 2 0 AAA domain RNase_PH PF01138.21 EMD69792.1 - 6.3e-24 85.0 0.0 1.3e-23 84.0 0.0 1.5 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 Glyco_hydro_72 PF03198.14 EMD69793.1 - 1.2e-117 392.7 0.9 1.5e-117 392.3 0.9 1.1 1 0 0 1 1 1 1 Glucanosyltransferase Cellulase PF00150.18 EMD69793.1 - 0.0061 16.0 0.2 0.014 14.8 0.2 1.6 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Ribonuclease_3 PF00636.26 EMD69794.1 - 3.1e-38 130.6 0.0 6.5e-18 65.3 0.0 3.0 2 0 0 2 2 2 2 Ribonuclease III domain Dicer_dimer PF03368.14 EMD69794.1 - 3.2e-25 88.1 0.1 5.9e-24 84.0 0.0 2.5 2 0 0 2 2 2 1 Dicer dimerisation domain Helicase_C PF00271.31 EMD69794.1 - 1.6e-17 63.9 0.1 4.3e-17 62.5 0.1 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Ribonucleas_3_3 PF14622.6 EMD69794.1 - 5.5e-16 58.9 0.0 2.6e-07 30.9 0.0 3.4 2 1 0 2 2 2 2 Ribonuclease-III-like ResIII PF04851.15 EMD69794.1 - 2.4e-10 40.7 0.1 5.6e-10 39.5 0.1 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EMD69794.1 - 2.4e-09 37.2 0.0 5.4e-09 36.1 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase TAP42 PF04177.12 EMD69795.1 - 1.2e-111 372.9 1.2 1.4e-111 372.7 1.2 1.0 1 0 0 1 1 1 1 TAP42-like family DUF4011 PF13195.6 EMD69795.1 - 0.004 17.1 1.0 0.0064 16.4 1.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF4011) ELM2 PF01448.24 EMD69795.1 - 0.063 14.0 0.0 0.23 12.3 0.0 2.1 1 1 0 1 1 1 0 ELM2 domain Terminase_4 PF05119.12 EMD69795.1 - 0.063 13.7 0.5 0.16 12.4 0.3 1.9 2 0 0 2 2 2 0 Phage terminase, small subunit Lipase_GDSL PF00657.22 EMD69796.1 - 4.5e-14 52.9 0.0 5.6e-14 52.6 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.6 EMD69796.1 - 7.7e-14 52.5 0.1 1.6e-12 48.2 0.1 2.1 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family SpoIISA_toxin PF14171.6 EMD69796.1 - 0.058 13.1 0.2 0.087 12.5 0.2 1.2 1 0 0 1 1 1 0 Toxin SpoIISA, type II toxin-antitoxin system Glyco_hydro_71 PF03659.14 EMD69798.1 - 8.6e-70 235.4 0.1 1.1e-69 235.1 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 71 Hamartin PF04388.12 EMD69799.1 - 2.1e-14 53.2 50.0 2.5e-13 49.7 44.3 4.5 1 1 1 2 2 2 1 Hamartin protein GIT_CC PF16559.5 EMD69799.1 - 0.014 15.2 2.2 0.014 15.2 2.2 4.7 5 0 0 5 5 5 0 GIT coiled-coil Rho guanine nucleotide exchange factor Plasmid_RAQPRD PF09686.10 EMD69799.1 - 0.089 13.0 2.2 0.43 10.8 2.2 2.3 1 0 0 1 1 1 0 Plasmid protein of unknown function (Plasmid_RAQPRD) Plasmid_parti PF01672.16 EMD69799.1 - 0.14 12.8 1.0 0.44 11.2 1.0 1.8 1 0 0 1 1 1 0 Putative plasmid partition protein DUF3584 PF12128.8 EMD69799.1 - 0.48 7.9 34.0 1.3 6.5 34.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) PGC7_Stella PF15549.6 EMD69800.1 - 0.012 15.6 3.3 0.018 15.0 3.3 1.3 1 0 0 1 1 1 0 PGC7/Stella/Dppa3 domain Filament PF00038.21 EMD69800.1 - 0.019 14.6 7.3 0.029 13.9 7.3 1.2 1 0 0 1 1 1 0 Intermediate filament protein Asp-B-Hydro_N PF05279.11 EMD69800.1 - 0.3 11.1 4.3 0.42 10.6 4.3 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Atg14 PF10186.9 EMD69800.1 - 1.1 8.3 8.1 1.8 7.6 8.1 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Rrn6 PF10214.9 EMD69801.1 - 1.1e-225 752.0 0.8 1.5e-225 751.6 0.8 1.0 1 0 0 1 1 1 1 RNA polymerase I-specific transcription-initiation factor DUF3237 PF11578.8 EMD69801.1 - 2.9e-40 137.5 0.1 5.4e-40 136.6 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3237) NARP1 PF12569.8 EMD69801.1 - 0.65 8.8 3.3 27 3.5 0.0 2.2 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 DUF5321 PF17254.2 EMD69801.1 - 3.9 6.9 7.1 7.2 6.0 7.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5321) Spindle_Spc25 PF08234.12 EMD69802.1 - 2.8e-27 94.7 0.3 2.8e-27 94.7 0.3 2.0 2 0 0 2 2 2 1 Chromosome segregation protein Spc25 HEPN_AbiU2 PF18734.1 EMD69802.1 - 0.0041 16.7 1.1 0.0083 15.7 1.1 1.6 1 0 0 1 1 1 1 AbiU2 Atg14 PF10186.9 EMD69802.1 - 0.11 11.6 7.4 0.17 10.9 7.4 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 FAM76 PF16046.5 EMD69802.1 - 0.84 8.9 5.1 1.2 8.4 5.1 1.2 1 0 0 1 1 1 0 FAM76 protein TMPIT PF07851.13 EMD69802.1 - 9.5 5.4 7.7 14 4.8 7.7 1.2 1 0 0 1 1 1 0 TMPIT-like protein HA2 PF04408.23 EMD69803.1 - 7.7e-20 71.2 0.2 1.6e-19 70.2 0.2 1.6 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EMD69803.1 - 1.1e-13 51.3 0.0 2.7e-13 50.1 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EMD69803.1 - 5.1e-12 46.1 0.0 1.1e-11 45.1 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EMD69803.1 - 1.6e-06 28.0 0.1 3.4e-06 27.0 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EMD69803.1 - 8.3e-06 26.1 0.0 2.6e-05 24.5 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EMD69803.1 - 0.0013 18.5 0.0 0.0024 17.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EMD69803.1 - 0.0015 18.9 0.0 0.0032 17.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain cobW PF02492.19 EMD69803.1 - 0.015 14.9 0.1 0.21 11.1 0.0 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.12 EMD69803.1 - 0.064 13.2 0.1 0.12 12.2 0.1 1.4 1 0 0 1 1 1 0 NACHT domain SRP54 PF00448.22 EMD69803.1 - 0.082 12.5 0.0 1.1 8.8 0.0 2.3 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_23 PF13476.6 EMD69803.1 - 0.16 12.4 0.0 0.51 10.8 0.0 1.7 2 0 0 2 2 2 0 AAA domain EF-hand_7 PF13499.6 EMD69804.1 - 7.5e-08 32.7 0.4 1.9e-07 31.4 0.4 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 EMD69804.1 - 1.8e-06 27.4 1.5 0.008 16.0 0.1 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 EMD69804.1 - 4.7e-06 25.8 1.8 8.1e-05 21.9 0.1 2.3 2 0 0 2 2 2 1 EF hand EF-hand_5 PF13202.6 EMD69804.1 - 0.0001 21.6 0.1 0.00026 20.3 0.1 1.7 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.6 EMD69804.1 - 0.00056 19.7 0.7 0.00091 19.0 0.0 1.8 2 0 0 2 2 2 1 EF-hand domain pair PAXNEB PF05625.11 EMD69805.1 - 2.9e-112 375.5 0.0 3.3e-112 375.3 0.0 1.0 1 0 0 1 1 1 1 PAXNEB protein WD40 PF00400.32 EMD69806.1 - 3.4e-14 53.0 3.3 0.03 15.2 0.5 5.3 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD69806.1 - 0.0028 17.9 0.0 4.2 7.7 0.0 4.3 3 2 2 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain ATP_bind_1 PF03029.17 EMD69807.1 - 2e-76 256.9 0.0 7e-76 255.2 0.0 1.8 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein AAA_29 PF13555.6 EMD69807.1 - 0.0029 17.3 0.0 0.006 16.3 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_31 PF13614.6 EMD69807.1 - 0.0096 15.9 0.0 5.2 6.9 0.0 2.3 2 0 0 2 2 2 2 AAA domain RuvB_N PF05496.12 EMD69807.1 - 0.01 15.6 0.0 0.018 14.8 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 EMD69807.1 - 0.011 16.3 0.2 0.24 12.0 0.1 2.6 2 1 0 2 2 2 0 AAA domain AAA_16 PF13191.6 EMD69807.1 - 0.025 15.0 0.0 0.08 13.3 0.0 2.0 2 1 0 2 2 2 0 AAA ATPase domain AAA_17 PF13207.6 EMD69807.1 - 0.035 14.5 0.1 0.12 12.8 0.1 2.0 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 EMD69807.1 - 0.038 14.4 0.0 0.073 13.5 0.0 1.5 1 0 0 1 1 1 0 RNA helicase MeaB PF03308.16 EMD69807.1 - 0.045 12.7 0.0 0.096 11.7 0.0 1.5 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB KTI12 PF08433.10 EMD69807.1 - 0.056 12.9 0.0 0.095 12.1 0.0 1.3 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_22 PF13401.6 EMD69807.1 - 0.11 12.8 0.1 0.37 11.1 0.1 2.0 1 1 1 2 2 2 0 AAA domain AAA_33 PF13671.6 EMD69807.1 - 0.11 12.6 0.0 0.25 11.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain Fer4_NifH PF00142.18 EMD69807.1 - 0.21 11.0 0.3 2.1 7.7 0.3 2.1 1 1 0 1 1 1 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family Snf7 PF03357.21 EMD69808.1 - 3.4e-19 69.1 11.4 3.4e-19 69.1 11.4 1.8 1 1 1 2 2 2 1 Snf7 SKIP_SNW PF02731.15 EMD69808.1 - 0.94 9.1 17.4 0.17 11.5 2.1 2.5 2 0 0 2 2 2 0 SKIP/SNW domain ESSS PF10183.9 EMD69809.1 - 1.5e-16 60.5 0.0 1.6e-16 60.4 0.0 1.1 1 0 0 1 1 1 1 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) Glyco_hydro_7 PF00840.20 EMD69810.1 - 3.3e-201 668.7 16.3 3.8e-201 668.5 16.3 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 7 CarbpepA_inh PF02977.15 EMD69811.1 - 0.099 12.4 1.8 0.22 11.4 1.8 1.5 1 0 0 1 1 1 0 Carboxypeptidase A inhibitor Kei1 PF08552.11 EMD69812.1 - 4.9e-59 199.4 1.9 6.6e-59 199.0 1.9 1.2 1 0 0 1 1 1 1 Inositolphosphorylceramide synthase subunit Kei1 SUV3_C PF12513.8 EMD69814.1 - 9e-19 67.1 0.5 9e-19 67.1 0.5 2.3 2 0 0 2 2 2 1 Mitochondrial degradasome RNA helicase subunit C terminal Helicase_C PF00271.31 EMD69814.1 - 8.1e-11 42.3 0.0 1.6e-10 41.3 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Suv3_C_1 PF18147.1 EMD69814.1 - 2.2e-09 37.1 0.1 5e-09 35.9 0.1 1.7 1 0 0 1 1 1 1 Suv3 C-terminal domain 1 Sec1 PF00995.23 EMD69815.1 - 2.5e-120 403.4 0.0 3e-120 403.2 0.0 1.1 1 0 0 1 1 1 1 Sec1 family DIM1 PF02966.16 EMD69816.1 - 5.5e-61 204.2 0.1 6.1e-61 204.0 0.1 1.0 1 0 0 1 1 1 1 Mitosis protein DIM1 Thioredoxin PF00085.20 EMD69816.1 - 0.0035 17.3 0.1 0.0045 16.9 0.1 1.1 1 0 0 1 1 1 1 Thioredoxin F-box-like PF12937.7 EMD69818.1 - 1.5e-08 34.4 0.0 4.3e-08 32.9 0.0 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EMD69818.1 - 9.9e-08 31.7 0.3 2.9e-07 30.2 0.0 2.0 2 0 0 2 2 2 1 F-box domain F-box_5 PF18511.1 EMD69818.1 - 0.43 10.2 1.6 0.82 9.3 0.0 2.1 2 0 0 2 2 2 0 F-box Ribosom_S12_S23 PF00164.25 EMD69819.1 - 1.2e-31 108.7 1.2 1.7e-31 108.2 1.2 1.2 1 0 0 1 1 1 1 Ribosomal protein S12/S23 Ribosomal_S12 PF17487.2 EMD69819.1 - 0.14 12.9 0.0 0.31 11.8 0.0 1.6 1 1 0 1 1 1 0 Ribosomal protein S12 NAD_binding_2 PF03446.15 EMD69820.1 - 7.2e-39 133.5 0.1 1.1e-38 132.9 0.1 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 EMD69820.1 - 6.4e-27 94.2 0.1 1e-26 93.6 0.1 1.3 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase OCD_Mu_crystall PF02423.15 EMD69820.1 - 0.00048 19.2 0.0 0.00079 18.5 0.0 1.2 1 0 0 1 1 1 1 Ornithine cyclodeaminase/mu-crystallin family F420_oxidored PF03807.17 EMD69820.1 - 0.0013 19.3 0.0 0.003 18.1 0.0 1.7 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.19 EMD69820.1 - 0.0025 17.2 0.0 0.0045 16.4 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GFO_IDH_MocA PF01408.22 EMD69820.1 - 0.0073 17.1 0.0 0.015 16.1 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold DSPc PF00782.20 EMD69821.1 - 2.1e-27 95.6 0.0 1.4e-20 73.5 0.0 2.4 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EMD69821.1 - 0.00093 18.8 0.0 0.013 15.1 0.0 2.1 2 0 0 2 2 2 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 EMD69821.1 - 0.037 14.2 0.0 5.3 7.2 0.0 2.5 2 0 0 2 2 2 0 Inositol hexakisphosphate DNA_pol_delta_4 PF04081.13 EMD69822.1 - 1.7e-36 125.5 3.8 4e-36 124.2 3.8 1.7 1 1 0 1 1 1 1 DNA polymerase delta, subunit 4 DcpS PF05652.12 EMD69823.1 - 3.6e-34 117.7 0.0 5.9e-34 117.0 0.0 1.3 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme (DcpS) N-terminal DcpS_C PF11969.8 EMD69823.1 - 1.9e-30 105.7 0.0 2.7e-30 105.1 0.0 1.3 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding Git3 PF11710.8 EMD69824.1 - 1.9e-26 93.1 6.6 1.9e-26 93.1 6.6 1.9 2 1 0 2 2 2 1 G protein-coupled glucose receptor regulating Gpa2 GPR_Gpa2_C PF11970.8 EMD69824.1 - 1.8e-20 72.8 3.2 3.9e-20 71.7 3.2 1.6 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 C-term Peptidase_C12 PF01088.21 EMD69825.1 - 3e-58 197.1 0.0 3.6e-58 196.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 tRNA_bind PF01588.20 EMD69826.1 - 7.2e-22 77.3 0.1 1.9e-21 76.0 0.1 1.7 1 1 0 1 1 1 1 Putative tRNA binding domain GST_C_2 PF13410.6 EMD69826.1 - 0.00089 19.2 0.0 0.0016 18.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EMD69826.1 - 0.004 17.3 1.4 0.013 15.7 0.0 2.5 3 0 0 3 3 3 1 Glutathione S-transferase, C-terminal domain Pol_alpha_B_N PF08418.10 EMD69826.1 - 3.1 7.7 7.0 7 6.5 2.6 2.1 2 0 0 2 2 2 0 DNA polymerase alpha subunit B N-terminal Sad1_UNC PF07738.13 EMD69827.1 - 2.7e-20 72.7 0.0 3.4e-19 69.2 0.0 2.4 1 1 0 1 1 1 1 Sad1 / UNC-like C-terminal GDP_Man_Dehyd PF16363.5 EMD69828.1 - 7.8e-46 157.0 0.0 2.2e-45 155.5 0.0 1.7 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 EMD69828.1 - 2e-45 155.1 0.0 2.9e-45 154.6 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EMD69828.1 - 1.3e-16 60.4 0.1 5.8e-16 58.3 0.1 1.8 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 EMD69828.1 - 4.3e-13 49.0 0.0 3.8e-11 42.7 0.0 2.2 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 EMD69828.1 - 1.6e-11 43.9 0.0 2.4e-11 43.3 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain adh_short PF00106.25 EMD69828.1 - 1.3e-09 37.8 0.1 2.1e-09 37.1 0.1 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EMD69828.1 - 4.1e-06 26.8 0.0 9.4e-06 25.6 0.0 1.6 1 1 0 1 1 1 1 KR domain adh_short_C2 PF13561.6 EMD69828.1 - 7.7e-05 22.3 0.0 0.00013 21.6 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.6 EMD69828.1 - 0.0015 18.4 0.0 0.0026 17.7 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding NAD_binding_4 PF07993.12 EMD69828.1 - 0.0056 15.9 0.1 0.33 10.1 0.1 2.2 1 1 0 1 1 1 1 Male sterility protein NmrA PF05368.13 EMD69828.1 - 0.0086 15.6 0.0 0.073 12.6 0.0 2.1 2 0 0 2 2 2 1 NmrA-like family MCM PF00493.23 EMD69829.1 - 1.4e-103 344.8 0.4 2.1e-103 344.2 0.4 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EMD69829.1 - 6.2e-38 129.5 0.9 1.2e-37 128.6 0.9 1.5 1 0 0 1 1 1 1 MCM OB domain MCM6_C PF18263.1 EMD69829.1 - 2.9e-32 111.1 6.2 7e-32 109.9 6.2 1.7 1 0 0 1 1 1 1 MCM6 C-terminal winged-helix domain MCM_lid PF17855.1 EMD69829.1 - 6.4e-25 87.4 0.3 6.4e-25 87.4 0.3 2.7 3 0 0 3 3 3 1 MCM AAA-lid domain MCM_N PF14551.6 EMD69829.1 - 8.1e-23 81.0 0.3 3.4e-22 79.0 0.3 2.1 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 EMD69829.1 - 1.5e-08 34.3 0.4 7.3e-07 28.8 0.0 2.9 3 1 1 4 4 4 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 EMD69829.1 - 0.00099 19.0 0.0 0.002 18.0 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EMD69829.1 - 0.0011 18.7 0.0 0.0028 17.4 0.0 1.7 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_5 PF07728.14 EMD69829.1 - 0.0048 16.9 0.0 0.022 14.7 0.0 2.2 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) HA2 PF04408.23 EMD69830.1 - 3e-22 78.9 0.0 3e-22 78.9 0.0 2.5 3 0 0 3 3 3 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EMD69830.1 - 8.3e-21 74.2 0.0 1.9e-20 73.0 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EMD69830.1 - 7.5e-13 48.8 0.0 2.3e-12 47.2 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain S1 PF00575.23 EMD69830.1 - 2.5e-10 40.6 0.6 5.1e-10 39.5 0.6 1.5 1 0 0 1 1 1 1 S1 RNA binding domain AAA_22 PF13401.6 EMD69830.1 - 4.7e-05 23.7 0.0 0.00013 22.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain DEAD PF00270.29 EMD69830.1 - 0.00017 21.4 0.1 0.00049 19.9 0.1 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase T2SSE PF00437.20 EMD69830.1 - 0.00023 20.3 0.0 0.0007 18.7 0.0 1.8 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_30 PF13604.6 EMD69830.1 - 0.0027 17.5 0.0 0.0069 16.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.6 EMD69830.1 - 0.022 14.8 0.1 0.29 11.2 0.1 2.6 1 1 0 1 1 1 0 AAA domain AAA_19 PF13245.6 EMD69830.1 - 0.025 14.9 0.8 0.046 14.1 0.2 1.7 2 0 0 2 2 1 0 AAA domain RimM PF01782.18 EMD69830.1 - 0.031 14.5 0.1 0.083 13.1 0.1 1.7 1 0 0 1 1 1 0 RimM N-terminal domain DUF2075 PF09848.9 EMD69830.1 - 0.055 12.7 0.0 0.11 11.7 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) SRP54 PF00448.22 EMD69830.1 - 0.067 12.8 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain Microtub_bd PF16796.5 EMD69830.1 - 0.07 13.1 0.0 1.6 8.6 0.0 2.4 2 0 0 2 2 2 0 Microtubule binding AAA_16 PF13191.6 EMD69830.1 - 0.079 13.3 0.0 0.24 11.8 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain AAA_7 PF12775.7 EMD69830.1 - 0.14 11.6 0.0 0.29 10.6 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region Herpes_ori_bp PF02399.15 EMD69830.1 - 0.14 10.1 0.1 0.23 9.5 0.1 1.2 1 0 0 1 1 1 0 Origin of replication binding protein TauD PF02668.16 EMD69832.1 - 1.6e-54 185.5 0.2 2.4e-54 184.9 0.2 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Glyco_transf_15 PF01793.16 EMD69833.1 - 1.5e-131 438.5 9.5 1.9e-131 438.2 9.5 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase PAT1 PF09770.9 EMD69834.1 - 0 1135.6 21.0 0 1135.4 21.0 1.0 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 TERB2 PF15101.6 EMD69834.1 - 9.4 6.2 10.9 30 4.6 10.9 1.8 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Asp PF00026.23 EMD69835.1 - 6.8e-65 219.6 5.4 8.8e-65 219.2 5.4 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EMD69835.1 - 2.4e-07 31.2 2.7 0.001 19.3 0.8 3.1 2 1 1 3 3 3 2 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 EMD69835.1 - 8.4e-07 29.5 1.8 0.0013 19.3 0.8 3.1 2 1 0 2 2 2 2 Aspartyl protease TAXi_C PF14541.6 EMD69835.1 - 0.063 13.1 0.0 0.18 11.6 0.0 1.8 1 0 0 1 1 1 0 Xylanase inhibitor C-terminal gag-asp_proteas PF13975.6 EMD69835.1 - 0.078 13.5 2.3 14 6.3 0.7 3.2 2 1 0 2 2 2 0 gag-polyprotein putative aspartyl protease UL73_N PF12522.8 EMD69835.1 - 0.7 9.7 5.1 1.8 8.4 5.1 1.7 1 0 0 1 1 1 0 Cytomegalovirus glycoprotein N terminal DUF775 PF05603.12 EMD69837.1 - 5.4e-62 208.9 0.0 6.3e-62 208.6 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF775) HD PF01966.22 EMD69838.1 - 3.1e-10 40.3 0.1 5.9e-10 39.4 0.1 1.4 1 0 0 1 1 1 1 HD domain HDOD PF08668.12 EMD69838.1 - 0.0052 16.3 0.1 0.02 14.4 0.0 1.9 1 1 0 2 2 2 1 HDOD domain Asparaginase PF00710.20 EMD69839.1 - 8.9e-51 172.2 1.0 1.6e-50 171.3 1.0 1.4 1 0 0 1 1 1 1 Asparaginase, N-terminal Asparaginase_C PF17763.1 EMD69839.1 - 1.7e-18 66.9 0.0 4.5e-18 65.5 0.0 1.7 2 0 0 2 2 2 1 Glutaminase/Asparaginase C-terminal domain IML1 PF12257.8 EMD69840.1 - 2.6e-117 391.0 0.0 3.7e-117 390.5 0.0 1.2 1 0 0 1 1 1 1 Vacuolar membrane-associated protein Iml1 DEP PF00610.21 EMD69840.1 - 2.9e-25 88.1 0.2 6.5e-25 87.0 0.2 1.7 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) NAD_binding_10 PF13460.6 EMD69841.1 - 4e-22 79.0 0.4 2.7e-21 76.3 0.4 1.9 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EMD69841.1 - 0.0047 16.4 0.0 0.0064 16.0 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 EMD69841.1 - 0.0048 16.0 0.0 0.0083 15.3 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain GDP_Man_Dehyd PF16363.5 EMD69841.1 - 0.012 15.0 0.0 0.037 13.4 0.0 1.6 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase Cation_ATPase_C PF00689.21 EMD69842.1 - 1.2e-47 162.0 9.9 1.2e-47 162.0 9.9 2.7 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 EMD69842.1 - 2.4e-38 131.5 0.7 2.4e-38 131.5 0.7 2.7 4 0 0 4 4 4 1 E1-E2 ATPase Hydrolase PF00702.26 EMD69842.1 - 4.3e-19 69.6 0.4 1.7e-18 67.7 0.4 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EMD69842.1 - 1e-18 67.2 0.0 2.3e-18 66.1 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 EMD69842.1 - 9.5e-08 31.6 0.0 1.2e-06 28.1 0.0 2.6 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EMD69842.1 - 5.7e-07 29.5 0.1 4.1e-05 23.5 0.2 2.3 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase BatA PF07584.11 EMD69842.1 - 1.8 9.0 3.9 4.1 7.8 0.1 3.7 4 0 0 4 4 4 0 Aerotolerance regulator N-terminal MFS_1 PF07690.16 EMD69843.1 - 1.7e-38 132.5 56.8 1.5e-31 109.6 30.3 2.9 3 1 0 3 3 3 2 Major Facilitator Superfamily TRI12 PF06609.13 EMD69843.1 - 5e-07 28.5 21.4 6.5e-07 28.2 21.4 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Neurensin PF14927.6 EMD69843.1 - 1.5 8.5 5.0 2.5 7.8 1.1 2.9 2 0 0 2 2 2 0 Neurensin Wzz PF02706.15 EMD69843.1 - 3.2 8.1 6.3 0.86 10.0 0.3 3.0 2 1 0 2 2 2 0 Chain length determinant protein GATase PF00117.28 EMD69844.1 - 1.6e-11 44.3 0.0 2.2e-11 43.9 0.0 1.1 1 0 0 1 1 1 1 Glutamine amidotransferase class-I GATase_3 PF07685.14 EMD69844.1 - 0.00078 19.1 0.0 0.0011 18.6 0.0 1.2 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain GDA1_CD39 PF01150.17 EMD69845.1 - 9.8e-110 367.1 0.0 1.3e-109 366.7 0.0 1.1 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family F-box PF00646.33 EMD69846.1 - 0.12 12.3 0.1 0.35 10.8 0.1 1.8 1 0 0 1 1 1 0 F-box domain RNA_pol_Rpb8 PF03870.15 EMD69847.1 - 3.3e-42 144.0 0.1 3.7e-42 143.8 0.1 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb8 RNA_pol_RpbG PF16992.5 EMD69847.1 - 0.0099 15.9 0.4 0.51 10.4 0.0 2.0 2 0 0 2 2 2 2 DNA-directed RNA polymerase, subunit G DUF4743 PF15916.5 EMD69848.1 - 6.3e-14 52.0 0.0 9.9e-14 51.3 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4743) NUDIX PF00293.28 EMD69848.1 - 1.2e-10 41.6 0.2 1.9e-10 40.9 0.2 1.3 1 0 0 1 1 1 1 NUDIX domain PHB_depo_C PF06850.11 EMD69848.1 - 0.14 11.6 0.0 0.25 10.8 0.0 1.3 1 0 0 1 1 1 0 PHB de-polymerase C-terminus Met_10 PF02475.16 EMD69849.1 - 2.8e-06 27.2 0.0 5.5e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 Met-10+ like-protein FNIP_N PF14636.6 EMD69850.1 - 1.2e-34 120.5 0.0 1.2e-34 120.5 0.0 4.7 4 1 1 5 5 5 1 Folliculin-interacting protein N-terminus GST_N_2 PF13409.6 EMD69851.1 - 1.2e-21 76.7 0.0 3.8e-21 75.2 0.0 1.9 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EMD69851.1 - 3.9e-13 49.2 0.0 8.7e-13 48.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EMD69851.1 - 9.2e-06 26.0 0.2 0.00014 22.2 0.2 2.4 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EMD69851.1 - 2.8e-05 24.2 0.0 6.8e-05 23.0 0.0 1.9 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain QIL1 PF15884.5 EMD69851.1 - 0.11 13.0 0.2 0.87 10.2 0.0 2.3 2 1 1 3 3 3 0 MICOS complex subunit MIC13, QIL1 Nucleoporin_FG PF13634.6 EMD69852.1 - 7.3e-13 49.2 60.6 1.4e-06 29.1 21.1 3.1 2 1 0 2 2 2 2 Nucleoporin FG repeat region DUF1664 PF07889.12 EMD69852.1 - 0.0022 18.0 0.3 0.44 10.6 0.0 2.7 2 1 1 3 3 3 1 Protein of unknown function (DUF1664) MIP-T3_C PF17749.1 EMD69852.1 - 0.0033 17.4 0.3 0.052 13.5 0.2 2.4 2 0 0 2 2 2 1 Microtubule-binding protein MIP-T3 C-terminal region DUF1515 PF07439.11 EMD69852.1 - 0.046 13.8 0.5 0.12 12.5 0.5 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1515) Not3 PF04065.15 EMD69852.1 - 0.11 11.9 0.0 0.19 11.2 0.0 1.4 1 0 0 1 1 1 0 Not1 N-terminal domain, CCR4-Not complex component Tmemb_cc2 PF10267.9 EMD69852.1 - 0.16 11.1 2.8 0.13 11.4 0.3 1.9 2 0 0 2 2 2 0 Predicted transmembrane and coiled-coil 2 protein Fip1 PF05182.13 EMD69853.1 - 2.3e-18 65.4 1.5 4.5e-18 64.5 1.5 1.5 1 0 0 1 1 1 1 Fip1 motif Rib_recp_KP_reg PF05104.12 EMD69853.1 - 0.04 15.0 7.1 0.06 14.4 7.1 1.3 1 0 0 1 1 1 0 Ribosome receptor lysine/proline rich region YL1 PF05764.13 EMD69853.1 - 0.13 12.4 3.9 0.16 12.1 3.9 1.2 1 0 0 1 1 1 0 YL1 nuclear protein TFIIF_alpha PF05793.12 EMD69853.1 - 0.76 8.3 9.9 1.1 7.8 9.9 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Nop14 PF04147.12 EMD69853.1 - 7.5 4.6 12.3 9.4 4.3 12.3 1.1 1 0 0 1 1 1 0 Nop14-like family LRR_9 PF14580.6 EMD69854.1 - 1.7e-59 200.2 0.1 2.3e-59 199.8 0.1 1.2 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 EMD69854.1 - 1.3e-10 41.3 6.7 7.6e-06 26.2 2.1 3.8 3 2 1 4 4 4 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EMD69854.1 - 7.5e-09 35.2 0.8 7.5e-09 35.2 0.8 2.8 4 0 0 4 4 4 1 Leucine rich repeat LRR_6 PF13516.6 EMD69854.1 - 0.0003 20.6 2.2 16 5.8 0.0 5.0 5 0 0 5 5 5 1 Leucine Rich repeat Gal11_ABD1 PF18535.1 EMD69854.1 - 0.16 12.1 0.1 0.34 11.0 0.1 1.5 1 0 0 1 1 1 0 Gal11 activator-binding domain (ABD1) Glycos_transf_1 PF00534.20 EMD69855.1 - 3.4e-32 111.3 0.0 3.8e-31 107.9 0.0 2.2 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 EMD69855.1 - 3.2e-16 59.8 0.1 6.6e-16 58.8 0.1 1.6 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_4 PF13692.6 EMD69855.1 - 7.8e-14 52.2 0.1 2.4e-13 50.7 0.1 1.9 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 EMD69855.1 - 4e-07 30.6 0.6 1.6e-06 28.7 0.0 2.2 2 1 0 2 2 2 1 Glycosyl transferase 4-like domain ALG11_N PF15924.5 EMD69855.1 - 0.00011 22.3 0.4 0.31 11.1 0.1 2.9 1 1 1 2 2 2 2 ALG11 mannosyltransferase N-terminus Glyco_trans_1_2 PF13524.6 EMD69855.1 - 0.016 15.5 0.0 0.038 14.4 0.0 1.6 1 0 0 1 1 1 0 Glycosyl transferases group 1 Pkinase PF00069.25 EMD69856.1 - 1e-17 64.4 0.0 1.9e-17 63.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain HEAT PF02985.22 EMD69856.1 - 7.3e-11 41.4 9.3 0.056 13.7 0.1 6.6 6 0 0 6 6 6 3 HEAT repeat HEAT_2 PF13646.6 EMD69856.1 - 2.1e-08 34.4 1.1 0.075 13.4 0.2 3.8 3 0 0 3 3 3 3 HEAT repeats WD40 PF00400.32 EMD69856.1 - 2.3e-08 34.6 10.4 4.7e-07 30.4 0.1 5.3 5 0 0 5 5 5 1 WD domain, G-beta repeat Cnd1 PF12717.7 EMD69856.1 - 0.0012 18.9 0.4 0.45 10.5 0.0 3.3 3 0 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 Pkinase_Tyr PF07714.17 EMD69856.1 - 0.042 13.1 0.0 0.094 12.0 0.0 1.5 1 0 0 1 1 1 0 Protein tyrosine kinase HEAT_EZ PF13513.6 EMD69856.1 - 0.043 14.3 1.8 0.54 10.8 0.2 3.4 4 0 0 4 4 4 0 HEAT-like repeat RTP1_C1 PF10363.9 EMD69856.1 - 0.066 13.4 0.2 3.7 7.8 0.0 2.6 2 0 0 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 Chorismate_bind PF00425.18 EMD69856.1 - 0.13 11.8 0.0 5.3 6.5 0.0 2.3 2 0 0 2 2 2 0 chorismate binding enzyme Aa_trans PF01490.18 EMD69858.1 - 2.3e-41 141.9 25.6 2.7e-41 141.7 25.6 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 EMD69858.1 - 3e-07 29.8 11.2 3e-07 29.8 11.2 2.0 2 0 0 2 2 2 1 Tryptophan/tyrosine permease family Spore_permease PF03845.13 EMD69858.1 - 0.03 13.1 15.0 0.15 10.9 0.5 2.4 2 0 0 2 2 2 0 Spore germination protein DNA_meth_N PF18284.1 EMD69859.1 - 0.051 13.5 0.1 0.061 13.2 0.1 1.1 1 0 0 1 1 1 0 DNA methylase N-terminal domain zf-CCHC_5 PF14787.6 EMD69861.1 - 0.013 15.2 0.9 0.024 14.3 0.9 1.4 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger zf-CCHC_2 PF13696.6 EMD69861.1 - 0.027 14.3 4.1 0.047 13.5 4.1 1.4 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC PF00098.23 EMD69861.1 - 0.1 12.7 1.5 0.15 12.2 1.5 1.3 1 0 0 1 1 1 0 Zinc knuckle WD40_alt PF14077.6 EMD69862.1 - 0.035 14.0 0.7 0.051 13.4 0.7 1.3 1 0 0 1 1 1 0 Alternative WD40 repeat motif 2OG-FeII_Oxy PF03171.20 EMD69871.1 - 1.3e-18 67.4 0.0 2.4e-18 66.5 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 EMD69871.1 - 7.1e-15 55.8 0.0 1.2e-14 55.1 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal RNA_pol PF00940.19 EMD69872.1 - 3e-181 602.8 0.1 4.6e-181 602.2 0.1 1.3 1 0 0 1 1 1 1 DNA-dependent RNA polymerase RPOL_N PF14700.6 EMD69872.1 - 1.6e-83 280.9 5.9 1.6e-83 280.9 5.9 1.9 2 0 0 2 2 2 1 DNA-directed RNA polymerase N-terminal Peptidase_C58 PF03543.14 EMD69872.1 - 3.8 7.2 6.4 1.3 8.7 0.1 3.2 4 0 0 4 4 4 0 Yersinia/Haemophilus virulence surface antigen HTH_psq PF05225.16 EMD69873.1 - 9.9e-07 28.4 0.0 1.5e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 helix-turn-helix, Psq domain SpoIIID PF12116.8 EMD69873.1 - 0.0057 16.7 0.0 0.007 16.4 0.0 1.2 1 0 0 1 1 1 1 Stage III sporulation protein D HTH_24 PF13412.6 EMD69873.1 - 0.0094 15.5 0.1 0.018 14.6 0.1 1.5 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding CENP-B_N PF04218.13 EMD69873.1 - 0.038 13.6 0.0 0.066 12.9 0.0 1.4 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain p450 PF00067.22 EMD69875.1 - 4.4e-62 210.3 0.0 5e-62 210.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 LPMO_10 PF03067.15 EMD69877.1 - 4.3e-07 30.8 0.6 7e-07 30.1 0.6 1.4 1 0 0 1 1 1 1 Lytic polysaccharide mono-oxygenase, cellulose-degrading But2 PF09792.9 EMD69878.1 - 2.5e-28 99.3 0.1 3.1e-28 99.0 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin 3 binding protein But2 C-terminal domain Radical_SAM PF04055.21 EMD69879.1 - 5.6e-11 43.1 0.0 8.5e-11 42.5 0.0 1.3 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_12 PF13353.6 EMD69879.1 - 0.00011 22.4 0.0 0.00022 21.5 0.0 1.5 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_14 PF13394.6 EMD69879.1 - 0.054 13.6 0.1 0.23 11.6 0.1 2.1 2 0 0 2 2 2 0 4Fe-4S single cluster domain WPP PF13943.6 EMD69879.1 - 0.14 12.6 0.0 0.27 11.6 0.0 1.5 1 0 0 1 1 1 0 WPP domain Pentapeptide PF00805.22 EMD69879.1 - 0.19 11.4 0.9 3.3 7.5 0.1 2.3 2 0 0 2 2 2 0 Pentapeptide repeats (8 copies) TPR_2 PF07719.17 EMD69881.1 - 0.14 12.4 0.0 0.35 11.1 0.0 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat Pec_lyase_C PF00544.19 EMD69882.1 - 5.6e-39 133.9 2.8 9.2e-39 133.2 2.8 1.3 1 0 0 1 1 1 1 Pectate lyase WD40 PF00400.32 EMD69883.1 - 6.1e-51 169.3 11.7 2.3e-12 47.2 0.2 4.7 4 0 0 4 4 4 4 WD domain, G-beta repeat NACHT PF05729.12 EMD69883.1 - 1.5e-27 96.5 0.1 2.8e-27 95.7 0.1 1.4 1 0 0 1 1 1 1 NACHT domain ANAPC4_WD40 PF12894.7 EMD69883.1 - 4.2e-17 62.2 0.1 0.0014 18.8 0.0 5.4 2 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain HET PF06985.11 EMD69883.1 - 2.1e-11 44.4 0.2 2.1e-11 44.4 0.2 3.7 3 1 1 4 4 4 2 Heterokaryon incompatibility protein (HET) Ge1_WD40 PF16529.5 EMD69883.1 - 1e-08 34.5 5.2 0.0016 17.4 0.6 3.5 1 1 1 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein AAA_16 PF13191.6 EMD69883.1 - 0.0022 18.4 1.1 0.0071 16.7 0.0 2.5 3 0 0 3 3 3 1 AAA ATPase domain Frtz PF11768.8 EMD69883.1 - 0.013 13.8 0.0 0.35 9.1 0.0 2.3 1 1 1 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz AAA_19 PF13245.6 EMD69883.1 - 0.1 13.0 0.0 0.21 11.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain PIF1 PF05970.14 EMD69883.1 - 0.12 11.5 0.0 0.22 10.6 0.0 1.3 1 0 0 1 1 1 0 PIF1-like helicase PsbW PF07123.12 EMD69884.1 - 0.28 11.2 2.1 2.7 8.0 0.3 2.2 1 1 1 2 2 2 0 Photosystem II reaction centre W protein (PsbW) DIM PF08194.12 EMD69884.1 - 0.36 11.1 0.1 0.36 11.1 0.1 2.1 2 0 0 2 2 2 0 DIM protein Fungal_trans PF04082.18 EMD69885.1 - 2.9e-12 46.2 0.0 5.9e-12 45.2 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD69885.1 - 4.1e-08 33.2 9.5 8.8e-08 32.2 9.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Sporozoite_P67 PF05642.11 EMD69885.1 - 0.94 7.5 4.2 1.3 7.0 4.2 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen HTH_Tnp_Tc5 PF03221.16 EMD69887.1 - 2.6e-09 37.0 0.1 4.8e-09 36.1 0.1 1.5 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EMD69887.1 - 0.001 18.8 0.1 0.0015 18.2 0.1 1.3 1 0 0 1 1 1 1 helix-turn-helix, Psq domain TnsD PF15978.5 EMD69887.1 - 0.019 14.0 0.1 0.023 13.7 0.1 1.1 1 0 0 1 1 1 0 Tn7-like transposition protein D Ribosomal_S13_N PF08069.12 EMD69887.1 - 0.02 14.9 0.0 0.033 14.2 0.0 1.4 1 0 0 1 1 1 0 Ribosomal S13/S15 N-terminal domain Cdc6_C PF09079.11 EMD69887.1 - 0.041 13.9 0.0 5.7 7.0 0.0 2.2 2 0 0 2 2 2 0 CDC6, C terminal winged helix domain HTH_24 PF13412.6 EMD69887.1 - 0.049 13.2 0.1 0.47 10.1 0.0 2.2 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding Drf_GBD PF06371.13 EMD69887.1 - 0.054 13.1 0.0 0.059 12.9 0.0 1.1 1 0 0 1 1 1 0 Diaphanous GTPase-binding Domain DUF2721 PF11026.8 EMD69887.1 - 0.29 11.0 1.0 0.45 10.4 1.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2721) MFS_1 PF07690.16 EMD69888.1 - 5.8e-06 25.5 10.4 6.5e-06 25.3 10.4 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily PLDc_N PF13396.6 EMD69889.1 - 2.6e-12 46.5 4.8 2.6e-12 46.5 4.8 1.5 2 0 0 2 2 2 1 Phospholipase_D-nuclease N-terminal MFS_MOT1 PF16983.5 EMD69889.1 - 0.022 15.2 1.0 0.028 14.8 1.0 1.1 1 0 0 1 1 1 0 Molybdate transporter of MFS superfamily Pox_A14 PF05767.12 EMD69889.1 - 0.057 13.6 0.2 0.057 13.6 0.2 1.5 2 0 0 2 2 2 0 Poxvirus virion envelope protein A14 DUF1673 PF07895.11 EMD69889.1 - 0.12 12.0 3.6 0.13 11.9 3.6 1.2 1 1 0 1 1 1 0 Protein of unknown function (DUF1673) Glucos_trans_II PF14264.6 EMD69889.1 - 0.21 10.9 6.9 0.36 10.2 6.9 1.5 1 1 0 1 1 1 0 Glucosyl transferase GtrII DUF4293 PF14126.6 EMD69889.1 - 0.34 11.2 2.5 0.94 9.7 0.2 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4293) MAP17 PF15807.5 EMD69889.1 - 8.7 6.6 9.7 0.28 11.4 1.7 1.9 1 1 1 2 2 2 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Ammonium_transp PF00909.21 EMD69891.1 - 8.5e-109 363.9 27.4 1e-108 363.6 27.4 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family DUF3482 PF11981.8 EMD69891.1 - 0.027 13.9 2.4 0.046 13.1 2.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3482) Rhomboid PF01694.22 EMD69892.1 - 3.1e-15 56.5 11.8 5.6e-15 55.6 11.8 1.4 1 0 0 1 1 1 1 Rhomboid family Methyltransf_33 PF10017.9 EMD69895.1 - 1.2e-93 313.7 0.0 1.6e-93 313.2 0.0 1.1 1 0 0 1 1 1 1 Histidine-specific methyltransferase, SAM-dependent FGE-sulfatase PF03781.16 EMD69895.1 - 1.3e-20 74.1 0.6 3.8e-10 39.8 0.2 2.3 2 0 0 2 2 2 2 Sulfatase-modifying factor enzyme 1 DinB_2 PF12867.7 EMD69895.1 - 0.0064 17.0 0.6 0.019 15.5 0.5 1.8 1 1 0 1 1 1 1 DinB superfamily PEMT PF04191.13 EMD69897.1 - 1.1e-59 199.4 10.0 5.1e-36 123.3 1.2 2.6 2 0 0 2 2 2 2 Phospholipid methyltransferase HECW_N PF16562.5 EMD69897.1 - 0.0035 17.1 0.0 0.0093 15.8 0.0 1.7 1 0 0 1 1 1 1 N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2 YWFCY PF14293.6 EMD69897.1 - 0.1 12.9 0.4 0.61 10.4 0.3 2.3 2 0 0 2 2 2 0 YWFCY protein SKICH PF17751.1 EMD69897.1 - 0.14 12.7 0.1 0.64 10.6 0.1 2.1 1 1 0 1 1 1 0 SKICH domain Lon_C PF05362.13 EMD69898.1 - 2.9e-64 216.4 0.4 5.7e-64 215.4 0.4 1.4 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain LON_substr_bdg PF02190.16 EMD69898.1 - 9.9e-26 90.9 0.2 2.8e-25 89.4 0.2 1.8 1 0 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain AAA PF00004.29 EMD69898.1 - 1.2e-23 83.9 0.1 1e-22 81.0 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EMD69898.1 - 8.9e-08 32.2 0.0 3.2e-07 30.4 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) ChlI PF13541.6 EMD69898.1 - 1.5e-07 31.3 0.3 2.2e-06 27.5 0.0 2.4 2 0 0 2 2 2 1 Subunit ChlI of Mg-chelatase AAA_16 PF13191.6 EMD69898.1 - 6.7e-06 26.6 0.0 3.2e-05 24.4 0.0 2.2 1 0 0 1 1 1 1 AAA ATPase domain IstB_IS21 PF01695.17 EMD69898.1 - 0.00011 21.9 0.0 0.0003 20.6 0.0 1.7 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_3 PF07726.11 EMD69898.1 - 0.00011 22.0 0.0 0.00036 20.4 0.0 1.8 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EMD69898.1 - 0.00018 21.3 0.0 0.001 18.9 0.0 2.2 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain TIP49 PF06068.13 EMD69898.1 - 0.00042 19.6 0.0 0.0011 18.3 0.0 1.7 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_22 PF13401.6 EMD69898.1 - 0.00074 19.8 0.0 0.016 15.5 0.0 2.8 1 1 1 2 2 2 1 AAA domain AAA_2 PF07724.14 EMD69898.1 - 0.00092 19.4 0.0 0.0043 17.2 0.0 2.1 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 EMD69898.1 - 0.0037 17.4 0.0 0.01 16.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 EMD69898.1 - 0.019 14.9 0.0 0.075 12.9 0.0 2.0 2 0 0 2 2 2 0 NACHT domain RNA_helicase PF00910.22 EMD69898.1 - 0.024 15.0 0.0 0.073 13.5 0.0 1.8 1 0 0 1 1 1 0 RNA helicase AAA_PrkA PF08298.11 EMD69898.1 - 0.026 13.4 0.4 4.2 6.2 0.1 2.3 2 0 0 2 2 2 0 PrkA AAA domain NB-ARC PF00931.22 EMD69898.1 - 0.032 13.4 0.0 0.061 12.5 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain AAA_18 PF13238.6 EMD69898.1 - 0.034 14.7 0.0 0.11 13.1 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 EMD69898.1 - 0.048 13.2 0.0 0.12 11.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EMD69898.1 - 0.056 13.0 0.0 0.12 11.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region Mg_chelatase PF01078.21 EMD69898.1 - 0.059 12.7 0.2 0.15 11.4 0.2 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI NTPase_1 PF03266.15 EMD69898.1 - 0.063 13.2 0.1 0.25 11.2 0.1 2.1 1 1 0 1 1 1 0 NTPase ATPase_2 PF01637.18 EMD69898.1 - 0.078 12.9 0.0 0.67 9.8 0.0 2.6 2 1 1 3 3 3 0 ATPase domain predominantly from Archaea AAA_14 PF13173.6 EMD69898.1 - 0.081 13.0 0.0 0.19 11.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 EMD69898.1 - 0.083 12.9 0.0 0.21 11.6 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_24 PF13479.6 EMD69898.1 - 0.084 12.6 0.0 0.18 11.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 EMD69898.1 - 0.093 12.6 0.0 0.22 11.4 0.0 1.6 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_23 PF13476.6 EMD69898.1 - 0.094 13.2 8.2 0.17 12.4 0.0 3.1 1 1 1 2 2 1 0 AAA domain RsgA_GTPase PF03193.16 EMD69898.1 - 0.097 12.6 0.1 0.3 11.0 0.0 1.9 2 0 0 2 2 1 0 RsgA GTPase ABC_tran PF00005.27 EMD69898.1 - 1.1 9.7 3.6 1.4 9.4 0.0 2.8 3 1 0 3 3 2 0 ABC transporter SPX PF03105.19 EMD69900.1 - 0.014 15.4 11.5 0.019 14.9 11.5 1.3 1 0 0 1 1 1 0 SPX domain Mitofilin PF09731.9 EMD69900.1 - 0.2 10.5 15.3 0.28 10.0 15.3 1.3 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Apt1 PF10351.9 EMD69900.1 - 0.35 9.7 8.1 0.41 9.4 8.1 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain Presenilin PF01080.17 EMD69900.1 - 0.44 9.3 13.9 0.71 8.6 13.9 1.3 1 0 0 1 1 1 0 Presenilin FYVE_2 PF02318.16 EMD69900.1 - 0.52 10.5 30.3 2.5 8.3 1.9 3.4 2 1 1 3 3 3 0 FYVE-type zinc finger Lin-8 PF03353.15 EMD69900.1 - 1.1 8.8 16.2 1.9 8.0 16.2 1.4 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist ATF7IP_BD PF16788.5 EMD69900.1 - 1.5 8.8 17.4 3 7.9 17.4 1.4 1 0 0 1 1 1 0 ATF-interacting protein binding domain DUF2052 PF09747.9 EMD69900.1 - 3.5 7.7 13.1 1.1 9.4 9.1 2.0 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Pannexin_like PF12534.8 EMD69900.1 - 6.2 5.8 10.5 11 4.9 10.5 1.4 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 zf-C3HC4 PF00097.25 EMD69900.1 - 8.6 6.3 37.8 4.7 7.2 6.2 3.7 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) Striatin PF08232.12 EMD69900.1 - 9.6 6.8 21.0 2.7 8.6 16.0 2.4 2 1 0 2 2 2 0 Striatin family Med3 PF11593.8 EMD69902.1 - 6.7 5.8 8.2 13 4.8 8.2 1.4 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal MOR2-PAG1_N PF14222.6 EMD69904.1 - 6.7e-201 669.0 0.0 1.2e-200 668.2 0.0 1.5 1 0 0 1 1 1 1 Cell morphogenesis N-terminal MOR2-PAG1_C PF14225.6 EMD69904.1 - 1.6e-87 293.6 1.0 1.6e-87 293.6 1.0 2.2 2 0 0 2 2 2 1 Cell morphogenesis C-terminal MOR2-PAG1_mid PF14228.6 EMD69904.1 - 2.6e-37 128.1 2.9 1.4e-14 52.8 0.1 4.1 3 1 1 4 4 4 4 Cell morphogenesis central region FAD_binding_1 PF00667.20 EMD69906.1 - 1.7e-60 204.4 0.0 2.5e-60 203.8 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 EMD69906.1 - 1.1e-34 119.6 0.8 1.1e-34 119.6 0.8 1.8 2 0 0 2 2 2 1 Flavodoxin NAD_binding_1 PF00175.21 EMD69906.1 - 5.1e-20 72.2 0.2 1.7e-19 70.5 0.1 1.9 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain Bromodomain PF00439.25 EMD69906.1 - 0.0084 16.2 0.0 0.025 14.6 0.0 1.9 1 0 0 1 1 1 1 Bromodomain Beta-Casp PF10996.8 EMD69906.1 - 0.13 12.5 0.0 0.43 10.9 0.0 1.8 1 0 0 1 1 1 0 Beta-Casp domain RRM_1 PF00076.22 EMD69907.1 - 5.6e-07 29.3 0.1 0.056 13.3 0.0 3.1 2 1 1 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) LAX PF15681.5 EMD69907.1 - 0.18 10.6 0.6 3.6 6.3 0.1 2.2 2 0 0 2 2 2 0 Lymphocyte activation family X RPN1_RPN2_N PF17781.1 EMD69908.1 - 3.6e-116 387.9 0.8 3.6e-116 387.9 0.8 1.6 2 0 0 2 2 2 1 RPN1/RPN2 N-terminal domain RPN1_C PF18051.1 EMD69908.1 - 4.6e-30 103.4 0.1 7.9e-30 102.7 0.1 1.4 1 0 0 1 1 1 1 26S proteasome non-ATPase regulatory subunit RPN1 C-terminal PC_rep PF01851.22 EMD69908.1 - 3.4e-20 71.4 23.0 7.3e-07 29.3 0.3 9.0 9 1 0 9 9 9 4 Proteasome/cyclosome repeat HEAT_2 PF13646.6 EMD69908.1 - 2.1e-08 34.4 1.5 0.0028 18.0 0.1 4.3 3 2 1 4 4 4 3 HEAT repeats IFRD PF05004.13 EMD69908.1 - 0.043 12.9 0.7 0.17 10.9 0.7 2.0 1 1 0 1 1 1 0 Interferon-related developmental regulator (IFRD) RIO1 PF01163.22 EMD69909.1 - 1.2e-41 142.4 0.0 2e-41 141.6 0.0 1.4 1 0 0 1 1 1 1 RIO1 family Rio2_N PF09202.11 EMD69909.1 - 3.2e-31 107.4 0.0 7.4e-31 106.2 0.0 1.6 1 0 0 1 1 1 1 Rio2, N-terminal APH PF01636.23 EMD69909.1 - 6.5e-08 32.8 0.1 0.0039 17.1 0.0 2.8 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 EMD69909.1 - 1.6e-06 27.7 0.0 0.019 14.3 0.0 2.2 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family IF-2B PF01008.17 EMD69911.1 - 1.9e-55 188.1 0.0 2.3e-55 187.8 0.0 1.1 1 0 0 1 1 1 1 Initiation factor 2 subunit family DeoRC PF00455.22 EMD69911.1 - 0.035 14.1 0.0 0.45 10.4 0.0 2.3 1 1 0 1 1 1 0 DeoR C terminal sensor domain ATP_bind_2 PF03668.15 EMD69912.1 - 8.8e-06 25.2 0.0 1.2e-05 24.8 0.0 1.1 1 0 0 1 1 1 1 P-loop ATPase protein family Rsc14 PF08586.10 EMD69912.1 - 0.036 14.9 0.4 0.06 14.2 0.1 1.6 2 0 0 2 2 2 0 RSC complex, Rsc14/Ldb7 subunit SLAC1 PF03595.17 EMD69914.1 - 2.9e-78 263.4 42.4 3.4e-78 263.2 42.4 1.0 1 0 0 1 1 1 1 Voltage-dependent anion channel Glyco_hydro_79C PF16862.5 EMD69915.1 - 1.7e-20 73.8 3.5 5.6e-20 72.2 3.5 1.9 1 0 0 1 1 1 1 Glycosyl hydrolase family 79 C-terminal beta domain DUF1939 PF09154.10 EMD69915.1 - 0.017 15.2 0.3 0.074 13.2 0.3 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1939) Microtub_bd PF16796.5 EMD69915.1 - 0.085 12.8 0.0 0.22 11.5 0.0 1.6 1 0 0 1 1 1 0 Microtubule binding ERG2_Sigma1R PF04622.12 EMD69916.1 - 3.7e-95 317.2 0.1 4.4e-95 317.0 0.1 1.0 1 0 0 1 1 1 1 ERG2 and Sigma1 receptor like protein DUF3606 PF12244.8 EMD69916.1 - 0.12 12.4 0.0 6.6 6.7 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3606) Acetyltransf_9 PF13527.7 EMD69918.1 - 9e-09 35.5 0.2 5.1e-07 29.8 0.0 2.2 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EMD69918.1 - 1.4e-07 31.5 0.0 2.3e-07 30.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EMD69918.1 - 5.3e-06 26.8 0.0 8.9e-06 26.0 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EMD69918.1 - 1.9e-05 24.8 0.0 3e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 EMD69918.1 - 0.0053 16.7 0.0 0.01 15.8 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein GNAT_acetyltran PF12746.7 EMD69918.1 - 0.14 11.7 0.0 0.23 11.0 0.0 1.3 1 0 0 1 1 1 0 GNAT acetyltransferase NUDIX PF00293.28 EMD69919.1 - 1.8e-26 92.7 0.0 2.4e-26 92.3 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain HMGL-like PF00682.19 EMD69920.1 - 4.9e-78 262.3 0.5 8.1e-78 261.6 0.5 1.3 1 0 0 1 1 1 1 HMGL-like Nuf2 PF03800.14 EMD69921.1 - 5.8e-43 146.4 0.5 1.2e-42 145.3 0.1 1.8 2 0 0 2 2 2 1 Nuf2 family DHR10 PF18595.1 EMD69921.1 - 4.7e-32 110.5 14.5 4.7e-32 110.5 14.5 3.8 2 2 2 4 4 4 1 Designed helical repeat protein 10 domain Thioredoxin PF00085.20 EMD69924.1 - 1.2e-27 95.9 0.1 1.7e-27 95.4 0.1 1.2 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_9 PF14595.6 EMD69924.1 - 7.6e-05 22.5 0.0 0.0001 22.1 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 EMD69924.1 - 9.4e-05 22.8 0.5 0.00058 20.3 0.5 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain OST3_OST6 PF04756.13 EMD69924.1 - 0.00056 19.3 0.0 0.00061 19.2 0.0 1.2 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_8 PF13905.6 EMD69924.1 - 0.0016 18.7 0.0 0.031 14.6 0.0 2.3 1 1 1 2 2 2 1 Thioredoxin-like Phosducin PF02114.16 EMD69924.1 - 0.017 14.1 0.0 0.019 13.9 0.0 1.1 1 0 0 1 1 1 0 Phosducin Redoxin PF08534.10 EMD69924.1 - 0.023 14.4 0.3 0.55 9.9 0.2 2.1 1 1 1 2 2 2 0 Redoxin TraF PF13728.6 EMD69924.1 - 0.062 13.1 0.0 0.098 12.5 0.0 1.4 1 0 0 1 1 1 0 F plasmid transfer operon protein F-box PF00646.33 EMD69925.1 - 0.001 18.8 0.2 0.0027 17.5 0.2 1.7 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 EMD69925.1 - 0.0013 18.6 0.3 0.0049 16.7 0.0 2.1 2 0 0 2 2 2 1 F-box F-box-like PF12937.7 EMD69925.1 - 0.019 14.8 0.2 0.069 13.1 0.2 2.0 1 0 0 1 1 1 0 F-box-like DUF2373 PF10180.9 EMD69926.1 - 1.5e-19 69.6 0.0 2.5e-19 68.9 0.0 1.4 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2373) Proteasome PF00227.26 EMD69927.1 - 4.4e-52 176.4 0.0 6e-52 175.9 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EMD69927.1 - 5e-13 48.5 0.3 8.3e-13 47.8 0.3 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Amidase_5 PF05382.13 EMD69927.1 - 0.082 12.8 0.3 4.4 7.2 0.0 2.4 2 1 0 2 2 2 0 Bacteriophage peptidoglycan hydrolase zf-RING_2 PF13639.6 EMD69929.1 - 7.9e-08 32.5 7.2 1.2e-07 31.9 7.2 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 EMD69929.1 - 2.9e-05 23.9 8.5 4.8e-05 23.1 8.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EMD69929.1 - 0.00046 20.0 5.3 0.00076 19.3 5.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EMD69929.1 - 0.00089 19.1 8.9 0.0019 18.0 8.9 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EMD69929.1 - 0.0014 18.7 3.1 0.014 15.4 4.0 2.1 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 EMD69929.1 - 0.0028 17.6 5.8 0.0052 16.8 5.8 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 EMD69929.1 - 0.0073 16.2 6.9 0.012 15.5 6.9 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_11 PF17123.5 EMD69929.1 - 0.028 14.2 1.3 0.028 14.2 1.3 1.7 2 0 0 2 2 2 0 RING-like zinc finger zf-rbx1 PF12678.7 EMD69929.1 - 0.035 14.4 6.2 0.074 13.3 6.2 1.5 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_4 PF14570.6 EMD69929.1 - 0.062 13.1 5.2 0.34 10.8 5.4 2.0 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain Zn-C2H2_12 PF18112.1 EMD69929.1 - 0.63 10.6 1.9 9.4 6.8 0.4 2.4 2 0 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain Prok-RING_4 PF14447.6 EMD69929.1 - 0.79 9.6 6.8 0.78 9.7 1.0 2.3 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 DUF3552 PF12072.8 EMD69929.1 - 3.1 7.2 8.7 0.22 10.9 3.4 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3552) Pectate_lyase PF03211.13 EMD69930.1 - 3.9e-88 294.3 11.8 4.5e-88 294.1 11.8 1.0 1 0 0 1 1 1 1 Pectate lyase ICAM_N PF03921.14 EMD69930.1 - 0.96 9.2 4.6 1.1 9.0 3.3 1.8 2 0 0 2 2 2 0 Intercellular adhesion molecule (ICAM), N-terminal domain FoP_duplication PF13865.6 EMD69933.1 - 3.2 8.4 12.2 4.3 7.9 12.2 1.2 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 DUF1168 PF06658.12 EMD69934.1 - 3.2e-37 127.4 19.5 3.2e-37 127.4 19.5 1.6 2 1 0 2 2 2 1 Protein of unknown function (DUF1168) PPL5 PF18168.1 EMD69934.1 - 0.62 9.3 5.4 0.79 9.0 5.4 1.3 1 0 0 1 1 1 0 Prim-pol family 5 Vma12 PF11712.8 EMD69934.1 - 0.77 9.8 3.1 1.2 9.2 3.1 1.4 1 0 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase DUF1682 PF07946.14 EMD69934.1 - 1.7 7.7 15.5 2 7.6 15.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Peptidase_S49_N PF08496.10 EMD69934.1 - 4.7 7.3 9.4 8.1 6.5 9.4 1.5 1 0 0 1 1 1 0 Peptidase family S49 N-terminal XRN_M PF17846.1 EMD69934.1 - 5.9 5.7 8.5 7.6 5.4 8.5 1.1 1 0 0 1 1 1 0 Xrn1 helical domain His_Phos_1 PF00300.22 EMD69935.1 - 3.6e-27 95.3 0.0 8.8e-27 94.1 0.0 1.7 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) His_Phos_2 PF00328.22 EMD69935.1 - 0.0019 17.6 0.0 0.0037 16.7 0.0 1.4 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Fungal_trans_2 PF11951.8 EMD69936.1 - 9.4e-34 116.8 0.3 1.3e-33 116.4 0.3 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD69936.1 - 3.2e-07 30.3 8.5 5.9e-07 29.5 8.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain adh_short PF00106.25 EMD69937.1 - 3e-39 134.5 0.4 5.7e-39 133.6 0.4 1.4 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EMD69937.1 - 1.9e-37 129.1 0.3 4.9e-36 124.4 0.3 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EMD69937.1 - 7e-11 42.4 1.7 1.8e-10 41.0 0.0 2.1 2 0 0 2 2 2 1 KR domain Glu_dehyd_C PF16912.5 EMD69937.1 - 0.006 16.1 0.0 0.0095 15.4 0.0 1.3 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N PF00107.26 EMD69937.1 - 0.015 15.3 0.0 0.027 14.4 0.0 1.4 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Pyr_redox PF00070.27 EMD69937.1 - 0.015 15.9 0.2 0.047 14.3 0.1 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase HATPase_c PF02518.26 EMD69937.1 - 0.015 15.8 0.1 0.037 14.5 0.0 1.7 2 0 0 2 2 2 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase GDP_Man_Dehyd PF16363.5 EMD69937.1 - 0.054 12.9 0.1 0.14 11.6 0.0 1.6 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 EMD69937.1 - 0.055 12.9 0.1 0.13 11.7 0.0 1.6 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family DUF4131 PF13567.6 EMD69939.1 - 0.63 9.7 2.7 0.86 9.2 1.4 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) Peptidase_M24 PF00557.24 EMD69940.1 - 1.7e-36 125.9 0.3 2.7e-36 125.2 0.3 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 C2 PF00168.30 EMD69941.1 - 2.8e-16 59.7 0.0 4.7e-16 59.0 0.0 1.4 1 0 0 1 1 1 1 C2 domain FlxA PF14282.6 EMD69941.1 - 0.23 11.5 7.7 0.68 10.0 7.7 1.7 1 0 0 1 1 1 0 FlxA-like protein Sugar_tr PF00083.24 EMD69944.1 - 5.5e-86 289.2 34.1 6.9e-86 288.9 34.1 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD69944.1 - 2.1e-14 53.2 52.2 8.6e-12 44.6 23.9 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily GTP_EFTU PF00009.27 EMD69945.1 - 1.3e-49 168.4 0.0 2.1e-49 167.7 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain LepA_C PF06421.12 EMD69945.1 - 1.5e-42 144.1 2.3 2.3e-42 143.5 2.3 1.3 1 0 0 1 1 1 1 GTP-binding protein LepA C-terminus EFG_C PF00679.24 EMD69945.1 - 3.8e-18 65.3 0.0 8.6e-18 64.2 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 EMD69945.1 - 2.6e-07 30.9 0.0 5.8e-07 29.8 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EMD69945.1 - 2.6e-05 24.3 0.0 5.7e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase Ras PF00071.22 EMD69945.1 - 0.00051 19.7 0.0 0.0011 18.6 0.0 1.5 1 0 0 1 1 1 1 Ras family EFG_II PF14492.6 EMD69945.1 - 0.0017 18.4 0.0 0.0045 17.1 0.0 1.8 1 0 0 1 1 1 1 Elongation Factor G, domain II RF3_C PF16658.5 EMD69945.1 - 0.01 15.7 0.0 0.022 14.6 0.0 1.5 1 0 0 1 1 1 0 Class II release factor RF3, C-terminal domain SRPRB PF09439.10 EMD69945.1 - 0.013 14.9 0.1 0.039 13.4 0.0 1.9 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit Snurportin1 PF11538.8 EMD69945.1 - 0.33 11.2 3.4 0.7 10.1 3.4 1.5 1 0 0 1 1 1 0 Snurportin1 HORMA PF02301.18 EMD69946.1 - 4.7e-33 114.6 0.0 4.7e-33 114.6 0.0 1.6 2 0 0 2 2 2 1 HORMA domain ATG101 PF07855.12 EMD69946.1 - 0.00027 20.9 0.3 0.0011 19.0 0.3 1.9 1 1 0 1 1 1 1 Autophagy-related protein 101 DUF3530 PF12048.8 EMD69946.1 - 0.0055 16.2 0.2 0.76 9.1 0.1 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF3530) DUF4760 PF15956.5 EMD69946.1 - 0.039 14.1 0.5 0.085 13.0 0.1 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4760) DNA_pol_delta_4 PF04081.13 EMD69946.1 - 0.18 12.1 2.0 13 6.2 0.1 2.4 2 0 0 2 2 2 0 DNA polymerase delta, subunit 4 DUF4834 PF16118.5 EMD69946.1 - 0.96 10.4 5.5 2 9.4 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Glyco_trans_2_3 PF13632.6 EMD69947.1 - 2.1e-52 177.9 0.2 2.1e-52 177.9 0.2 2.1 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.26 EMD69947.1 - 5.6e-10 39.3 0.0 2.7e-07 30.6 0.0 3.0 3 1 0 3 3 3 2 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 EMD69947.1 - 1e-05 25.6 0.0 1.8e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 EMD69947.1 - 0.00071 19.1 0.0 0.0021 17.6 0.0 1.8 1 1 0 1 1 1 1 Glycosyl transferase family 21 Aldedh PF00171.22 EMD69948.1 - 4.2e-112 375.0 0.9 4.6e-112 374.9 0.9 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family MFS_1 PF07690.16 EMD69949.1 - 5.6e-33 114.3 29.2 5.6e-33 114.3 29.2 1.6 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EMD69949.1 - 7e-11 41.7 4.3 7e-11 41.7 4.3 1.9 2 0 0 2 2 2 1 Sugar (and other) transporter DUF3638 PF12340.8 EMD69950.1 - 2.4e-88 295.3 0.1 5.3e-88 294.2 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3638) DUF3645 PF12359.8 EMD69950.1 - 1.8e-14 52.8 0.3 4.1e-14 51.7 0.3 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3645) BTB PF00651.31 EMD69951.1 - 8.5e-06 26.0 0.0 1.2e-05 25.5 0.0 1.2 1 0 0 1 1 1 1 BTB/POZ domain CbbQ_C PF08406.10 EMD69951.1 - 0.064 13.5 0.0 0.11 12.8 0.0 1.3 1 0 0 1 1 1 0 CbbQ/NirQ/NorQ C-terminal Glyco_hydro_16 PF00722.21 EMD69952.1 - 2e-12 47.0 0.0 4.9e-12 45.7 0.0 1.7 1 1 0 1 1 1 1 Glycosyl hydrolases family 16 Acetyltransf_7 PF13508.7 EMD69954.1 - 0.011 16.1 0.0 0.026 15.0 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EMD69954.1 - 0.054 13.7 0.0 0.094 13.0 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EMD69954.1 - 0.16 11.9 0.0 0.31 11.0 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain FR47 PF08445.10 EMD69954.1 - 0.17 11.9 0.0 0.38 10.8 0.0 1.5 1 0 0 1 1 1 0 FR47-like protein MFS_1 PF07690.16 EMD69955.1 - 5e-42 144.1 46.7 5e-42 144.1 46.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EMD69955.1 - 1.7e-13 50.2 10.9 1.7e-13 50.2 10.9 3.0 1 1 0 2 2 2 1 Sugar (and other) transporter SLY PF12485.8 EMD69955.1 - 0.046 14.4 6.5 0.11 13.2 6.5 1.6 1 0 0 1 1 1 0 Lymphocyte signaling adaptor protein Miga PF10265.9 EMD69955.1 - 5.8 5.8 5.0 9.7 5.0 5.0 1.3 1 0 0 1 1 1 0 Mitoguardin adh_short_C2 PF13561.6 EMD69956.1 - 2.8e-58 197.2 0.2 3.3e-58 197.0 0.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EMD69956.1 - 2.3e-38 131.6 0.3 2.9e-38 131.3 0.3 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EMD69956.1 - 1.7e-14 54.1 0.1 2.3e-14 53.7 0.1 1.1 1 0 0 1 1 1 1 KR domain AvrLm4-7 PF18661.1 EMD69958.1 - 0.055 14.5 0.0 0.12 13.4 0.0 1.6 1 0 0 1 1 1 0 Avirulence Effector AvrLm4-7 DOG1 PF14144.6 EMD69958.1 - 0.38 11.0 5.7 2.2 8.6 1.4 2.6 1 1 1 2 2 2 0 Seed dormancy control DUF16 PF01519.16 EMD69958.1 - 0.63 10.6 8.4 0.67 10.5 1.0 2.4 1 1 1 2 2 2 0 Protein of unknown function DUF16 DUF778 PF05608.12 EMD69958.1 - 1.1 9.6 12.0 1.3 9.4 3.9 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF778) ALMT PF11744.8 EMD69958.1 - 6.9 5.4 12.9 0.99 8.2 9.1 1.4 2 0 0 2 2 2 0 Aluminium activated malate transporter NmrA PF05368.13 EMD69959.1 - 1.3e-15 57.7 0.0 2.5e-15 56.7 0.0 1.5 1 1 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EMD69959.1 - 9.6e-14 51.7 0.0 2.4e-13 50.4 0.0 1.6 2 0 0 2 2 2 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 EMD69959.1 - 0.00075 19.8 0.3 0.031 14.5 0.0 2.2 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain Semialdhyde_dh PF01118.24 EMD69959.1 - 0.013 15.9 0.0 0.036 14.5 0.0 1.8 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain TMEM108 PF15759.5 EMD69959.1 - 0.43 9.5 2.3 0.38 9.7 0.3 1.7 2 0 0 2 2 2 0 TMEM108 family MFS_1 PF07690.16 EMD69960.1 - 8.8e-49 166.3 48.1 4.9e-48 163.9 48.1 2.0 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 EMD69960.1 - 1.9e-16 59.7 13.7 1.9e-16 59.7 13.7 1.6 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 EMD69960.1 - 1.1e-12 47.6 5.0 1.1e-12 47.6 5.0 2.7 2 1 0 2 2 2 1 Sugar (and other) transporter OATP PF03137.20 EMD69960.1 - 1.7 6.8 17.3 0.88 7.8 1.7 3.4 3 1 1 4 4 4 0 Organic Anion Transporter Polypeptide (OATP) family MerC PF03203.14 EMD69960.1 - 6.3 7.3 28.7 0.19 12.2 7.6 3.7 3 2 1 4 4 4 0 MerC mercury resistance protein Neur_chan_memb PF02932.16 EMD69961.1 - 0.068 13.2 0.2 0.077 13.0 0.2 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Peptidase_M15_3 PF08291.11 EMD69962.1 - 0.13 12.3 0.0 0.23 11.6 0.0 1.4 1 0 0 1 1 1 0 Peptidase M15 Aa_trans PF01490.18 EMD69963.1 - 7.5e-34 117.1 36.6 9.3e-34 116.8 36.6 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein AA_permease PF00324.21 EMD69963.1 - 0.003 16.2 46.1 0.018 13.6 46.1 2.1 1 1 0 1 1 1 1 Amino acid permease Cutinase PF01083.22 EMD69964.1 - 6.7e-27 94.6 0.1 9.5e-27 94.1 0.1 1.2 1 0 0 1 1 1 1 Cutinase RhgB_N PF09284.10 EMD69966.1 - 5.6e-85 284.9 0.2 8.3e-85 284.3 0.2 1.3 1 0 0 1 1 1 1 Rhamnogalacturonan lyase B, N-terminal CBM-like PF14683.6 EMD69966.1 - 4.4e-34 117.7 0.0 4.3e-33 114.5 0.0 2.5 2 0 0 2 2 2 1 Polysaccharide lyase family 4, domain III fn3_3 PF14686.6 EMD69966.1 - 2.8e-15 55.8 2.1 2.8e-15 55.8 2.1 2.9 3 0 0 3 3 3 1 Polysaccharide lyase family 4, domain II CarboxypepD_reg PF13620.6 EMD69966.1 - 0.00012 22.2 0.4 0.00012 22.2 0.4 1.9 2 0 0 2 2 2 1 Carboxypeptidase regulatory-like domain DUF4278 PF14105.6 EMD69966.1 - 0.015 15.7 0.3 3.3 8.2 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4278) WW PF00397.26 EMD69967.1 - 4e-09 36.4 5.7 4e-09 36.4 5.7 2.0 2 0 0 2 2 2 1 WW domain DUF5445 PF17520.2 EMD69969.1 - 0.0064 16.3 0.0 0.014 15.2 0.0 1.5 1 0 0 1 1 1 1 Family of unknown function (DUF5445) OTU PF02338.19 EMD69972.1 - 5.5e-16 59.2 4.1 6e-16 59.1 0.4 2.6 2 1 0 2 2 2 1 OTU-like cysteine protease Peptidase_C65 PF10275.9 EMD69972.1 - 0.0033 16.9 0.0 1.6 8.1 0.0 2.5 1 1 0 2 2 2 2 Peptidase C65 Otubain Gly-rich_Ago1 PF12764.7 EMD69972.1 - 0.14 12.9 1.1 4.8 8.0 0.1 2.4 1 1 1 2 2 2 0 Glycine-rich region of argonaut Neur_chan_memb PF02932.16 EMD69972.1 - 1.9 8.5 8.7 2.9 7.9 8.7 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region TPMT PF05724.11 EMD69973.1 - 1.1e-26 93.8 0.0 8.1e-24 84.5 0.0 2.2 2 0 0 2 2 2 2 Thiopurine S-methyltransferase (TPMT) Methyltransf_23 PF13489.6 EMD69973.1 - 5.1e-06 26.4 0.0 8.1e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EMD69973.1 - 0.00049 20.8 0.0 0.0034 18.1 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMD69973.1 - 0.0038 17.8 0.0 0.013 16.1 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMD69973.1 - 0.013 16.2 0.0 0.039 14.7 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain N2227 PF07942.12 EMD69973.1 - 0.085 12.0 0.0 0.13 11.4 0.0 1.2 1 0 0 1 1 1 0 N2227-like protein MFS_1 PF07690.16 EMD69974.1 - 2.7e-44 151.6 31.4 2.7e-44 151.6 31.4 2.1 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EMD69974.1 - 1e-09 37.8 14.7 1e-09 37.8 14.7 2.8 2 1 0 2 2 2 1 Sugar (and other) transporter OATP PF03137.20 EMD69974.1 - 0.0046 15.3 0.4 0.0046 15.3 0.4 3.7 2 1 1 3 3 3 2 Organic Anion Transporter Polypeptide (OATP) family ABC_membrane PF00664.23 EMD69975.1 - 6.7e-81 271.9 33.9 6.9e-43 147.3 12.3 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EMD69975.1 - 1.2e-69 233.2 0.1 3e-34 118.5 0.0 2.5 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EMD69975.1 - 5.5e-15 55.4 1.8 1.3e-05 24.7 0.2 4.0 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 EMD69975.1 - 2.2e-10 41.2 1.7 0.00012 22.5 0.1 3.1 2 1 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 EMD69975.1 - 9.3e-08 32.4 1.0 0.022 15.0 0.1 3.6 2 2 0 2 2 2 2 AAA domain AAA_29 PF13555.6 EMD69975.1 - 1e-07 31.6 0.1 0.0043 16.8 0.0 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EMD69975.1 - 1.7e-07 31.3 0.1 0.0089 16.0 0.0 2.7 3 0 0 3 3 2 2 RsgA GTPase ABC_ATPase PF09818.9 EMD69975.1 - 8.9e-07 28.0 1.8 0.031 13.1 0.3 3.0 3 0 0 3 3 3 2 Predicted ATPase of the ABC class AAA_15 PF13175.6 EMD69975.1 - 9.6e-06 25.5 0.0 0.029 14.1 0.0 2.3 2 0 0 2 2 2 2 AAA ATPase domain Zeta_toxin PF06414.12 EMD69975.1 - 1.1e-05 24.8 0.3 0.011 15.0 0.0 2.8 3 0 0 3 3 3 2 Zeta toxin AAA_25 PF13481.6 EMD69975.1 - 2.4e-05 24.0 1.1 0.27 10.8 0.0 3.3 3 0 0 3 3 3 2 AAA domain AAA_33 PF13671.6 EMD69975.1 - 3.5e-05 24.0 0.1 0.11 12.7 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.14 EMD69975.1 - 7.8e-05 22.7 0.2 0.36 10.8 0.0 3.7 4 0 0 4 4 4 1 AAA domain (dynein-related subfamily) AAA_21 PF13304.6 EMD69975.1 - 9.2e-05 22.4 1.1 8.9 6.0 0.0 4.0 3 1 0 4 4 4 0 AAA domain, putative AbiEii toxin, Type IV TA system G-alpha PF00503.20 EMD69975.1 - 9.3e-05 21.7 0.0 0.097 11.8 0.0 2.2 2 0 0 2 2 2 2 G-protein alpha subunit SbcCD_C PF13558.6 EMD69975.1 - 0.0001 22.4 1.1 2 8.7 0.1 4.1 2 2 0 2 2 2 2 Putative exonuclease SbcCD, C subunit AAA_30 PF13604.6 EMD69975.1 - 0.00047 19.9 2.3 0.93 9.2 0.0 3.4 3 1 0 3 3 3 2 AAA domain AAA PF00004.29 EMD69975.1 - 0.00053 20.4 0.0 4.8 7.6 0.0 4.6 5 0 0 5 5 5 0 ATPase family associated with various cellular activities (AAA) AAA_23 PF13476.6 EMD69975.1 - 0.00054 20.5 0.0 0.77 10.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain Rad17 PF03215.15 EMD69975.1 - 0.0013 18.7 0.0 0.045 13.7 0.0 2.4 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_18 PF13238.6 EMD69975.1 - 0.0022 18.5 0.0 3.4 8.2 0.0 3.1 3 0 0 3 3 3 1 AAA domain MMR_HSR1 PF01926.23 EMD69975.1 - 0.0024 18.0 0.1 0.53 10.4 0.0 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase DUF3676 PF12429.8 EMD69975.1 - 0.006 16.4 0.3 0.012 15.4 0.3 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3676) SRP54 PF00448.22 EMD69975.1 - 0.01 15.5 0.2 3.2 7.3 0.0 2.5 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_28 PF13521.6 EMD69975.1 - 0.014 15.7 0.0 0.46 10.7 0.0 2.7 2 0 0 2 2 2 0 AAA domain DUF87 PF01935.17 EMD69975.1 - 0.016 15.3 0.8 3.2 7.8 0.2 2.7 2 0 0 2 2 2 0 Helicase HerA, central domain APS_kinase PF01583.20 EMD69975.1 - 0.016 15.1 0.4 6.3 6.7 0.1 2.9 3 0 0 3 3 3 0 Adenylylsulphate kinase MeaB PF03308.16 EMD69975.1 - 0.017 14.1 0.0 0.65 8.9 0.0 2.3 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB PRK PF00485.18 EMD69975.1 - 0.018 14.8 0.1 1.5 8.5 0.0 2.4 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family RNA_helicase PF00910.22 EMD69975.1 - 0.023 15.1 0.0 3.1 8.2 0.0 3.1 2 0 0 2 2 2 0 RNA helicase NB-ARC PF00931.22 EMD69975.1 - 0.023 13.9 0.1 1.4 8.0 0.0 2.3 2 0 0 2 2 2 0 NB-ARC domain AAA_7 PF12775.7 EMD69975.1 - 0.025 14.1 0.0 7.9 5.9 0.0 2.6 2 0 0 2 2 2 0 P-loop containing dynein motor region Ploopntkinase3 PF18751.1 EMD69975.1 - 0.054 13.4 0.2 5 7.0 0.0 2.7 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 DUF815 PF05673.13 EMD69975.1 - 0.078 12.1 0.1 8.9 5.4 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) TniB PF05621.11 EMD69975.1 - 0.086 12.2 0.0 15 4.9 0.0 3.5 4 0 0 4 4 4 0 Bacterial TniB protein AAA_24 PF13479.6 EMD69975.1 - 0.094 12.4 0.1 8 6.1 0.0 2.5 2 0 0 2 2 2 0 AAA domain ATP-synt_ab PF00006.25 EMD69975.1 - 0.14 11.8 0.0 2.4 7.8 0.0 2.6 3 0 0 3 3 3 0 ATP synthase alpha/beta family, nucleotide-binding domain DUF4234 PF14018.6 EMD69975.1 - 0.55 10.4 4.4 1.4 9.1 0.1 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4234) MFS_1 PF07690.16 EMD69976.1 - 2.5e-32 112.2 25.7 2.5e-32 112.2 25.7 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily MatE PF01554.18 EMD69977.1 - 8.8e-61 204.3 27.9 4.8e-36 123.9 9.1 2.3 2 0 0 2 2 2 2 MatE Pex2_Pex12 PF04757.14 EMD69977.1 - 1.4e-53 181.8 1.3 3.2e-53 180.6 1.3 1.6 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region Polysacc_synt_C PF14667.6 EMD69977.1 - 2.6e-05 24.3 11.3 2.6e-05 24.3 11.3 3.6 4 1 1 5 5 5 1 Polysaccharide biosynthesis C-terminal domain zf-C3HC4_4 PF15227.6 EMD69977.1 - 0.001 19.1 0.7 0.0018 18.4 0.7 1.4 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.6 EMD69977.1 - 0.0056 16.5 0.4 0.01 15.6 0.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EMD69977.1 - 0.0058 16.5 0.2 0.0093 15.8 0.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EMD69977.1 - 0.013 15.3 0.3 0.023 14.6 0.3 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EMD69977.1 - 0.019 15.0 1.2 0.035 14.1 1.2 1.4 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_2 PF13639.6 EMD69977.1 - 0.25 11.7 0.6 0.43 10.9 0.6 1.4 1 0 0 1 1 1 0 Ring finger domain Peptidase_M28 PF04389.17 EMD69978.1 - 2.9e-37 128.3 0.0 4.1e-37 127.8 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M28 PQ-loop PF04193.14 EMD69978.1 - 1.4e-22 79.2 15.9 8.8e-12 44.6 1.3 3.1 3 0 0 3 3 3 2 PQ loop repeat PA PF02225.22 EMD69978.1 - 6.1e-11 42.2 0.2 1.7e-10 40.8 0.2 1.7 1 0 0 1 1 1 1 PA domain Peptidase_M20 PF01546.28 EMD69978.1 - 7.4e-05 22.5 0.0 0.00021 21.1 0.0 1.8 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M42 PF05343.14 EMD69978.1 - 0.044 12.8 0.0 0.17 10.8 0.0 1.7 1 1 1 2 2 2 0 M42 glutamyl aminopeptidase GCP_N_terminal PF17681.1 EMD69982.1 - 3.5e-31 109.0 2.4 3.8e-31 108.9 0.5 1.9 2 0 0 2 2 2 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 EMD69982.1 - 1.2e-25 90.6 0.2 2.2e-25 89.7 0.2 1.5 1 1 0 1 1 1 1 Gamma tubulin complex component C-terminal Cytochrom_B559a PF00284.20 EMD69983.1 - 0.086 12.6 1.3 3.5 7.5 0.0 2.9 2 1 1 3 3 3 0 Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit F1F0-ATPsyn_F PF10791.9 EMD69985.1 - 5.3e-40 135.8 0.2 6e-40 135.6 0.2 1.0 1 0 0 1 1 1 1 Mitochondrial F1-F0 ATP synthase subunit F of fungi ETC_C1_NDUFA4 PF04800.12 EMD69986.1 - 1.3e-34 118.3 1.6 1.9e-34 117.8 1.6 1.3 1 0 0 1 1 1 1 ETC complex I subunit conserved region Lipase_GDSL_2 PF13472.6 EMD69988.1 - 3.6e-11 43.8 0.1 6.4e-11 43.0 0.1 1.3 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EMD69988.1 - 1.3e-05 25.2 0.0 1.5e-05 25.1 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase OSK PF17182.4 EMD69988.1 - 0.00012 21.4 0.0 0.00017 20.9 0.0 1.2 1 0 0 1 1 1 1 OSK domain PBP1_TM PF14812.6 EMD69990.1 - 2.4 8.6 7.4 0.45 10.9 1.7 2.5 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Pyridox_oxase_2 PF12766.7 EMD69992.1 - 4.6e-25 88.1 0.0 1.1e-24 86.9 0.0 1.7 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase CDC27 PF09507.10 EMD69993.1 - 8e-80 269.3 29.5 1.6e-79 268.3 29.5 1.4 1 1 0 1 1 1 1 DNA polymerase subunit Cdc27 TFCD_C PF12612.8 EMD69994.1 - 4e-26 92.0 3.5 3.7e-21 75.8 0.5 2.7 1 1 1 2 2 2 2 Tubulin folding cofactor D C terminal HEAT_EZ PF13513.6 EMD69994.1 - 0.0015 19.0 0.4 0.62 10.6 0.0 4.9 4 0 0 4 4 4 1 HEAT-like repeat HEAT_2 PF13646.6 EMD69994.1 - 0.0086 16.4 4.1 0.48 10.8 0.0 4.4 5 0 0 5 5 5 1 HEAT repeats Vac14_Fab1_bd PF12755.7 EMD69994.1 - 0.041 14.5 0.0 0.3 11.7 0.0 2.6 2 0 0 2 2 2 0 Vacuolar 14 Fab1-binding region IFRD PF05004.13 EMD69994.1 - 0.064 12.4 10.4 0.059 12.5 1.0 3.8 4 0 0 4 4 4 0 Interferon-related developmental regulator (IFRD) HEAT PF02985.22 EMD69994.1 - 0.21 11.9 17.4 4.9 7.7 0.0 7.9 9 0 0 9 9 9 0 HEAT repeat FANCI_HD1 PF14679.6 EMD69994.1 - 0.23 11.5 0.8 6.8 6.7 0.0 2.9 2 0 0 2 2 2 0 FANCI helical domain 1 DAO PF01266.24 EMD69995.1 - 1.2e-32 113.8 0.9 1.4e-32 113.7 0.9 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 EMD69995.1 - 0.018 14.3 2.4 0.018 14.3 0.1 2.1 2 0 0 2 2 2 0 Thi4 family Pyr_redox PF00070.27 EMD69995.1 - 0.024 15.2 0.1 0.053 14.1 0.1 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EMD69995.1 - 0.028 14.6 0.1 0.2 11.9 0.1 2.2 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain NAD_binding_7 PF13241.6 EMD69995.1 - 0.088 13.3 0.0 0.14 12.6 0.0 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding Pyr_redox_2 PF07992.14 EMD69995.1 - 0.094 11.9 0.1 0.32 10.2 0.0 1.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Sacchrp_dh_NADP PF03435.18 EMD69995.1 - 0.099 12.9 0.1 0.28 11.5 0.1 1.7 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain OTU PF02338.19 EMD69996.1 - 1.9e-12 47.8 0.2 2.9e-12 47.2 0.2 1.3 1 0 0 1 1 1 1 OTU-like cysteine protease Peptidase_C65 PF10275.9 EMD69996.1 - 9.8e-05 21.9 0.4 0.037 13.5 0.0 2.2 1 1 1 2 2 2 2 Peptidase C65 Otubain TRAPPC-Trs85 PF12739.7 EMD69997.1 - 1.3e-112 376.8 0.6 2.3e-112 376.0 0.6 1.3 1 0 0 1 1 1 1 ER-Golgi trafficking TRAPP I complex 85 kDa subunit TPR_2 PF07719.17 EMD69997.1 - 0.19 11.9 1.1 4.2 7.7 0.2 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat Tti2 PF10521.9 EMD69998.1 - 1.1e-72 245.0 1.3 1.7e-72 244.4 1.3 1.3 1 0 0 1 1 1 1 Tti2 family PolyA_pol PF01743.20 EMD69998.1 - 1.8e-21 76.9 0.7 3.7e-20 72.6 0.7 2.5 1 1 0 1 1 1 1 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.7 EMD69998.1 - 3e-08 33.3 0.1 9.4e-08 31.7 0.1 1.9 1 1 0 1 1 1 1 Probable RNA and SrmB- binding site of polymerase A tRNA_NucTran2_2 PF13735.6 EMD69998.1 - 2e-05 24.6 0.0 4.3e-05 23.5 0.0 1.6 1 0 0 1 1 1 1 tRNA nucleotidyltransferase domain 2 putative DUF1218 PF06749.12 EMD69999.1 - 2.3 8.8 11.0 0.39 11.3 5.5 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF1218) Npa1 PF11707.8 EMD70000.1 - 7e-96 321.5 0.2 5.4e-94 315.3 0.0 2.5 2 0 0 2 2 2 2 Ribosome 60S biogenesis N-terminal NopRA1 PF16201.5 EMD70000.1 - 1.5e-59 201.0 0.1 1.4e-58 197.8 0.0 2.5 2 0 0 2 2 2 1 Nucleolar pre-ribosomal-associated protein 1 RICTOR_M PF14666.6 EMD70000.1 - 7.3 6.4 5.6 42 4.0 0.1 4.0 5 0 0 5 5 5 0 Rapamycin-insensitive companion of mTOR, middle domain HET PF06985.11 EMD70002.1 - 2.3e-09 37.7 6.4 1.5e-06 28.6 0.2 3.2 2 1 1 3 3 3 2 Heterokaryon incompatibility protein (HET) NB-ARC PF00931.22 EMD70002.1 - 2.1e-08 33.7 0.0 8.4e-08 31.7 0.0 1.9 2 1 0 2 2 2 1 NB-ARC domain AAA_16 PF13191.6 EMD70002.1 - 3.2e-05 24.4 0.1 6.9e-05 23.3 0.1 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EMD70002.1 - 7.9e-05 23.0 0.0 0.00019 21.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 EMD70002.1 - 0.0012 18.8 0.0 0.0041 17.1 0.0 1.7 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea NACHT PF05729.12 EMD70002.1 - 0.0047 16.9 0.0 0.0099 15.8 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_35 PF14516.6 EMD70002.1 - 0.016 14.1 0.0 0.029 13.2 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain PhoH PF02562.16 EMD70002.1 - 0.023 14.1 0.0 0.04 13.4 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein AAA_25 PF13481.6 EMD70002.1 - 0.042 13.4 0.0 0.31 10.6 0.0 2.2 2 0 0 2 2 2 0 AAA domain TPR_12 PF13424.6 EMD70003.1 - 9.4e-41 138.0 0.1 1.3e-17 63.8 0.0 4.0 1 1 4 5 5 5 5 Tetratricopeptide repeat TPR_10 PF13374.6 EMD70003.1 - 2.2e-34 116.4 0.0 5.5e-11 42.0 0.0 4.2 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_2 PF07719.17 EMD70003.1 - 5.3e-09 35.5 0.0 0.053 13.7 0.0 3.8 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 EMD70003.1 - 1e-08 34.6 0.0 0.0097 15.7 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 EMD70003.1 - 1.4e-05 25.7 0.0 0.031 14.9 0.0 3.3 3 1 1 4 4 3 2 Tetratricopeptide repeat TPR_MalT PF17874.1 EMD70003.1 - 3.3e-05 23.4 0.1 0.1 11.9 0.0 2.1 1 1 1 2 2 2 2 MalT-like TPR region TPR_8 PF13181.6 EMD70003.1 - 3.5e-05 23.7 0.0 0.88 9.9 0.0 3.7 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 EMD70003.1 - 6.3e-05 23.3 0.2 6.1 7.7 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EMD70003.1 - 0.00023 21.3 0.0 0.35 11.1 0.0 3.0 3 0 0 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 EMD70003.1 - 0.00024 21.3 0.0 4.3 7.9 0.0 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.6 EMD70003.1 - 0.00037 20.3 0.2 3 8.1 0.0 3.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_4 PF07721.14 EMD70003.1 - 0.00087 19.7 0.0 6.9 7.6 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 EMD70003.1 - 0.0012 19.3 1.1 0.51 10.9 0.0 3.4 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 EMD70003.1 - 0.01 16.6 0.5 2.2 9.3 0.0 3.4 3 1 1 4 4 3 0 Tetratricopeptide repeat TPR_3 PF07720.12 EMD70003.1 - 0.02 14.9 0.0 0.93 9.6 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat Glyco_hydro_72 PF03198.14 EMD70004.1 - 5.3e-108 361.0 2.9 5.3e-108 361.0 2.9 1.7 2 0 0 2 2 2 1 Glucanosyltransferase X8 PF07983.13 EMD70004.1 - 9.1e-19 67.9 9.2 2.9e-18 66.3 9.2 1.9 1 0 0 1 1 1 1 X8 domain DsbC_N PF10411.9 EMD70004.1 - 0.12 11.8 0.2 0.34 10.4 0.1 1.8 2 0 0 2 2 2 0 Disulfide bond isomerase protein N-terminus bZIP_1 PF00170.21 EMD70005.1 - 1.2e-06 28.5 7.8 2.1e-06 27.8 7.8 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EMD70005.1 - 0.013 15.6 9.1 0.023 14.8 9.1 1.4 1 0 0 1 1 1 0 Basic region leucine zipper TMF_DNA_bd PF12329.8 EMD70005.1 - 0.036 14.1 1.3 0.064 13.3 1.3 1.3 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding TSC22 PF01166.18 EMD70005.1 - 0.049 13.9 0.1 0.12 12.7 0.1 1.6 1 0 0 1 1 1 0 TSC-22/dip/bun family NRBF2 PF08961.10 EMD70005.1 - 0.052 13.1 0.3 0.073 12.7 0.3 1.2 1 0 0 1 1 1 0 Nuclear receptor-binding factor 2, autophagy regulator DivIC PF04977.15 EMD70005.1 - 0.093 12.5 1.3 0.18 11.6 1.3 1.5 1 0 0 1 1 1 0 Septum formation initiator APG6_N PF17675.1 EMD70005.1 - 0.15 12.6 2.7 0.22 12.1 2.7 1.2 1 0 0 1 1 1 0 Apg6 coiled-coil region zf-C4H2 PF10146.9 EMD70005.1 - 0.17 12.1 3.0 0.32 11.3 3.0 1.4 1 0 0 1 1 1 0 Zinc finger-containing protein UPF0242 PF06785.11 EMD70005.1 - 0.3 11.2 1.8 0.43 10.7 1.8 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus RsfS PF02410.15 EMD70006.1 - 2.1e-14 53.7 0.0 4.4e-14 52.7 0.0 1.6 1 0 0 1 1 1 1 Ribosomal silencing factor during starvation DUF489 PF04356.12 EMD70006.1 - 0.19 11.7 0.0 0.31 11.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF489) XhlA PF10779.9 EMD70006.1 - 0.21 11.8 0.9 0.5 10.6 0.9 1.6 1 0 0 1 1 1 0 Haemolysin XhlA NMD3 PF04981.13 EMD70007.1 - 3.5e-78 262.4 1.6 5.4e-78 261.8 1.6 1.3 1 0 0 1 1 1 1 NMD3 family DZR PF12773.7 EMD70007.1 - 0.2 11.7 8.6 1.9e+02 2.2 8.6 3.0 1 1 0 1 1 1 0 Double zinc ribbon HypA PF01155.19 EMD70007.1 - 2.6 8.1 6.6 19 5.3 0.1 3.1 3 1 1 4 4 4 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA CENP-L PF13092.6 EMD70009.1 - 0.025 14.8 0.0 0.032 14.5 0.0 1.1 1 0 0 1 1 1 0 Kinetochore complex Sim4 subunit Fta1 5_3_exonuc_N PF02739.16 EMD70009.1 - 0.14 12.1 0.0 0.17 11.8 0.0 1.2 1 0 0 1 1 1 0 5'-3' exonuclease, N-terminal resolvase-like domain GMC_oxred_N PF00732.19 EMD70010.1 - 1.4e-49 169.1 0.0 1.8e-49 168.7 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EMD70010.1 - 4.4e-39 134.3 0.0 7.2e-39 133.6 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase DAO PF01266.24 EMD70010.1 - 0.00027 20.6 0.1 0.00085 19.0 0.1 1.8 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EMD70010.1 - 0.0014 17.9 0.1 0.46 9.7 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EMD70010.1 - 0.0027 16.8 0.1 0.0075 15.4 0.1 1.7 2 0 0 2 2 2 1 Lycopene cyclase protein NAD_binding_8 PF13450.6 EMD70010.1 - 0.015 15.5 0.2 0.033 14.4 0.2 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain HHH PF00633.23 EMD70010.1 - 0.061 13.2 0.2 3.8 7.5 0.0 2.8 2 0 0 2 2 2 0 Helix-hairpin-helix motif Thi4 PF01946.17 EMD70010.1 - 0.075 12.3 0.0 0.15 11.3 0.0 1.4 1 0 0 1 1 1 0 Thi4 family Pyr_redox_3 PF13738.6 EMD70010.1 - 0.094 12.0 2.0 2.4 7.3 1.2 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EMD70010.1 - 0.13 11.0 0.1 0.23 10.3 0.1 1.3 1 0 0 1 1 1 0 Tryptophan halogenase ATG16 PF08614.11 EMD70011.1 - 0.0048 17.1 2.7 0.0082 16.4 2.7 1.3 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) APG6_N PF17675.1 EMD70011.1 - 0.04 14.5 1.2 0.07 13.6 1.2 1.3 1 0 0 1 1 1 0 Apg6 coiled-coil region Cnn_1N PF07989.11 EMD70011.1 - 0.069 13.3 0.3 0.12 12.6 0.3 1.4 1 0 0 1 1 1 0 Centrosomin N-terminal motif 1 APC_N_CC PF16689.5 EMD70011.1 - 0.086 12.9 4.8 0.2 11.8 0.5 2.3 1 1 1 2 2 2 0 Coiled-coil N-terminus of APC, dimerisation domain Cep57_CLD_2 PF14197.6 EMD70011.1 - 1.1 9.4 5.5 0.45 10.6 2.8 1.8 2 1 0 2 2 2 0 Centrosome localisation domain of PPC89 Shugoshin_N PF07558.11 EMD70011.1 - 1.6 8.6 5.3 0.97 9.4 0.3 2.5 1 1 1 2 2 2 0 Shugoshin N-terminal coiled-coil region Glyco_hydro_30 PF02055.16 EMD70012.1 - 2.4e-10 39.9 0.0 3.9e-10 39.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 30 TIM-barrel domain Glyco_hydro_30C PF17189.4 EMD70012.1 - 3.3e-10 40.0 0.6 9.4e-10 38.6 0.6 1.8 1 1 0 1 1 1 1 Glycosyl hydrolase family 30 beta sandwich domain Glyco_hydro_59 PF02057.15 EMD70012.1 - 1.3e-07 31.1 0.1 1.8e-07 30.7 0.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 59 Glyco_hydr_30_2 PF14587.6 EMD70012.1 - 0.0011 18.6 0.1 0.045 13.3 0.0 2.5 3 0 0 3 3 3 1 O-Glycosyl hydrolase family 30 HET PF06985.11 EMD70013.1 - 3.4e-36 124.8 0.2 5.6e-36 124.1 0.2 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) SurE PF01975.17 EMD70015.1 - 2.3e-37 128.7 0.0 3.3e-37 128.2 0.0 1.2 1 0 0 1 1 1 1 Survival protein SurE Clr2_transil PF16761.5 EMD70016.1 - 5.2e-23 81.6 2.2 7.7e-23 81.1 1.0 2.0 2 0 0 2 2 2 1 Transcription-silencing protein, cryptic loci regulator Clr2 Clr2 PF10383.9 EMD70016.1 - 3.1e-16 60.4 0.0 1.4e-15 58.4 0.0 2.1 1 1 0 1 1 1 1 Transcription-silencing protein Clr2 SNF2_N PF00176.23 EMD70017.1 - 1.8e-57 194.7 0.1 1.6e-56 191.6 0.1 2.0 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EMD70017.1 - 3.6e-14 53.0 0.0 2.3e-13 50.5 0.0 2.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain HDA2-3 PF11496.8 EMD70017.1 - 0.0022 17.2 0.0 0.0062 15.7 0.0 1.8 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 PHD PF00628.29 EMD70017.1 - 0.025 14.5 17.6 0.018 15.0 5.4 2.8 3 0 0 3 3 3 0 PHD-finger C1_1 PF00130.22 EMD70017.1 - 0.056 13.3 18.7 0.28 11.1 4.5 2.5 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Zf_RING PF16744.5 EMD70017.1 - 0.14 12.3 14.0 0.16 12.1 2.2 3.3 3 0 0 3 3 3 0 KIAA1045 RING finger zf-dskA_traR PF01258.17 EMD70017.1 - 2.6 8.1 5.4 0.67 10.0 0.3 2.5 2 0 0 2 2 2 0 Prokaryotic dksA/traR C4-type zinc finger Thioredoxin PF00085.20 EMD70018.1 - 1.6e-09 37.7 0.0 2.2e-09 37.3 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Redoxin PF08534.10 EMD70018.1 - 0.0074 16.0 0.0 0.0095 15.7 0.0 1.2 1 0 0 1 1 1 1 Redoxin Thioredoxin_7 PF13899.6 EMD70018.1 - 0.0076 16.4 0.0 0.01 16.0 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like TraF PF13728.6 EMD70018.1 - 0.016 15.1 0.0 0.021 14.6 0.0 1.2 1 0 0 1 1 1 0 F plasmid transfer operon protein AhpC-TSA PF00578.21 EMD70018.1 - 0.02 14.8 0.0 0.028 14.3 0.0 1.2 1 0 0 1 1 1 0 AhpC/TSA family Thioredoxin_8 PF13905.6 EMD70018.1 - 0.059 13.7 0.0 0.3 11.4 0.0 1.9 1 1 1 2 2 2 0 Thioredoxin-like Thioredoxin_2 PF13098.6 EMD70018.1 - 0.075 13.5 0.0 1.9 9.0 0.0 2.2 2 0 0 2 2 2 0 Thioredoxin-like domain Glutaredoxin PF00462.24 EMD70018.1 - 0.18 12.0 0.1 0.49 10.7 0.1 1.6 1 1 0 1 1 1 0 Glutaredoxin Peptidase_C48 PF02902.19 EMD70019.1 - 0.0012 18.8 0.1 0.56 10.0 0.0 2.9 2 0 0 2 2 2 2 Ulp1 protease family, C-terminal catalytic domain DUF148 PF02520.17 EMD70020.1 - 0.043 13.9 3.7 2.2 8.4 0.3 2.2 1 1 1 2 2 2 0 Domain of unknown function DUF148 bZIP_1 PF00170.21 EMD70020.1 - 1.3 9.1 8.4 2.4 8.3 8.4 1.5 1 1 0 1 1 1 0 bZIP transcription factor His_Phos_1 PF00300.22 EMD70022.1 - 4.5e-20 72.2 0.0 6.5e-20 71.7 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) RNase_H2_suC PF08615.11 EMD70023.1 - 1.2e-28 100.0 0.0 1.5e-28 99.7 0.0 1.1 1 0 0 1 1 1 1 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) CMAS PF02353.20 EMD70024.1 - 7e-68 228.9 0.0 1.7e-67 227.6 0.0 1.5 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_25 PF13649.6 EMD70024.1 - 1.9e-10 41.3 0.0 3.7e-10 40.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMD70024.1 - 1.4e-09 38.5 0.0 2.6e-09 37.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EMD70024.1 - 2.5e-07 30.7 0.0 3.9e-07 30.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMD70024.1 - 2.5e-05 24.1 0.0 3.7e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EMD70024.1 - 5.6e-05 23.8 0.0 0.00012 22.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 EMD70024.1 - 0.0039 17.0 0.0 0.006 16.4 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_3 PF01596.17 EMD70024.1 - 0.01 15.0 0.0 0.019 14.1 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase RrnaAD PF00398.20 EMD70024.1 - 0.028 13.5 0.0 0.046 12.8 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase NUC153 PF08159.12 EMD70027.1 - 3.6e-14 52.3 0.5 3.6e-14 52.3 0.5 4.4 4 0 0 4 4 4 3 NUC153 domain SAM_decarbox PF01536.16 EMD70027.1 - 0.39 9.7 2.1 0.9 8.5 2.1 1.5 1 0 0 1 1 1 0 Adenosylmethionine decarboxylase DHquinase_II PF01220.19 EMD70029.1 - 9.3e-64 213.2 0.1 1.1e-63 213.0 0.1 1.0 1 0 0 1 1 1 1 Dehydroquinase class II Inositol_P PF00459.25 EMD70030.1 - 2.1e-82 276.7 0.0 2.3e-82 276.6 0.0 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family Shikimate_dh_N PF08501.11 EMD70031.1 - 1.7e-23 82.6 0.0 3.4e-23 81.7 0.0 1.5 1 0 0 1 1 1 1 Shikimate dehydrogenase substrate binding domain SDH_C PF18317.1 EMD70031.1 - 1.6e-05 24.6 0.0 3.2e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 Shikimate 5'-dehydrogenase C-terminal domain Shikimate_DH PF01488.20 EMD70031.1 - 0.027 14.5 0.0 0.042 13.9 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase DUF1143 PF06608.11 EMD70031.1 - 0.18 11.8 0.0 0.33 11.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1143) Sugar_tr PF00083.24 EMD70032.1 - 4.9e-135 450.9 20.5 5.6e-135 450.7 20.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD70032.1 - 1.6e-21 76.6 38.7 1.1e-20 73.9 36.8 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily AP_endonuc_2 PF01261.24 EMD70033.1 - 2e-35 122.2 0.0 6.3e-35 120.5 0.0 1.7 2 0 0 2 2 2 1 Xylose isomerase-like TIM barrel ATP-grasp PF02222.22 EMD70033.1 - 0.12 11.9 0.0 0.38 10.3 0.0 1.8 2 0 0 2 2 2 0 ATP-grasp domain Fungal_trans PF04082.18 EMD70034.1 - 6.2e-08 32.0 1.0 2.7e-07 29.9 1.0 2.1 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 EMD70034.1 - 2.3e-07 30.8 13.4 3.9e-07 30.1 13.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DHquinase_I PF01487.15 EMD70035.1 - 4.4e-25 89.3 0.0 8.3e-25 88.4 0.0 1.4 1 0 0 1 1 1 1 Type I 3-dehydroquinase Shikimate_dh_N PF08501.11 EMD70035.1 - 7e-18 64.7 0.0 1.7e-17 63.4 0.0 1.7 1 0 0 1 1 1 1 Shikimate dehydrogenase substrate binding domain SKI PF01202.22 EMD70035.1 - 3.2e-12 46.8 0.0 6e-12 46.0 0.0 1.4 1 0 0 1 1 1 1 Shikimate kinase SDH_C PF18317.1 EMD70035.1 - 6.2e-10 38.7 0.1 6.2e-10 38.7 0.1 2.3 3 0 0 3 3 3 1 Shikimate 5'-dehydrogenase C-terminal domain Shikimate_DH PF01488.20 EMD70035.1 - 1.5e-07 31.6 0.0 3.4e-07 30.4 0.0 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase AAA_8 PF12780.7 EMD70035.1 - 0.017 14.4 0.1 0.039 13.3 0.1 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region D4 AAA_5 PF07728.14 EMD70035.1 - 0.087 12.8 0.0 0.52 10.3 0.0 2.1 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EMD70035.1 - 0.14 12.5 0.0 0.79 10.1 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain WD40 PF00400.32 EMD70037.1 - 6.1e-30 102.8 10.9 8e-06 26.5 0.0 7.1 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD70037.1 - 1.1e-06 28.8 0.1 1.6 9.1 0.0 5.0 3 2 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EMD70037.1 - 2.4e-06 26.5 7.1 0.098 11.3 0.3 5.0 2 2 3 5 5 5 4 Nucleoporin Nup120/160 BBS2_Mid PF14783.6 EMD70037.1 - 0.00073 19.5 0.0 0.024 14.6 0.0 3.2 4 1 0 4 4 4 1 Ciliary BBSome complex subunit 2, middle region DUF5046 PF16465.5 EMD70037.1 - 0.0036 16.8 0.2 0.021 14.3 0.2 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF5046) APG6_N PF17675.1 EMD70037.1 - 0.054 14.0 0.6 0.14 12.7 0.6 1.6 1 0 0 1 1 1 0 Apg6 coiled-coil region Osmo_CC PF08946.10 EMD70037.1 - 0.58 10.4 3.6 13 6.1 0.2 2.6 2 0 0 2 2 2 0 Osmosensory transporter coiled coil HTH_psq PF05225.16 EMD70038.1 - 0.00022 20.9 0.1 0.0003 20.4 0.1 1.3 1 0 0 1 1 1 1 helix-turn-helix, Psq domain TnsD PF15978.5 EMD70038.1 - 0.044 12.8 0.1 0.049 12.6 0.1 1.0 1 0 0 1 1 1 0 Tn7-like transposition protein D HTH_24 PF13412.6 EMD70038.1 - 0.082 12.5 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding Pyr_redox_2 PF07992.14 EMD70039.1 - 1.8e-40 139.0 0.0 2.4e-40 138.6 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EMD70039.1 - 6e-12 46.0 0.0 2.9e-09 37.3 0.0 2.7 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase EF-hand_1 PF00036.32 EMD70039.1 - 1.5e-06 27.3 0.3 4.3e-06 25.9 0.3 1.9 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 EMD70039.1 - 1e-05 25.1 0.5 3.8e-05 23.3 0.5 2.0 1 0 0 1 1 1 1 EF-hand domain EF-hand_5 PF13202.6 EMD70039.1 - 8e-05 22.0 0.6 0.00022 20.6 0.6 1.8 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 EMD70039.1 - 0.0007 20.0 0.1 0.002 18.6 0.1 1.8 1 0 0 1 1 1 1 EF-hand domain pair Pyr_redox_3 PF13738.6 EMD70039.1 - 0.098 11.9 0.1 0.59 9.3 0.2 2.1 2 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase F-box-like PF12937.7 EMD70040.1 - 1.6e-07 31.1 1.0 2.8e-07 30.3 0.2 1.8 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EMD70040.1 - 7.2e-06 25.7 0.3 1.7e-05 24.6 0.3 1.5 1 0 0 1 1 1 1 F-box domain DUF1772 PF08592.11 EMD70041.1 - 8.1e-37 126.6 0.3 2e-36 125.3 0.3 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF1772) MFS_1 PF07690.16 EMD70042.1 - 4.5e-32 111.4 39.6 4.4e-23 81.8 14.8 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily ALG3 PF05208.13 EMD70043.1 - 6.2e-141 470.0 11.3 7.2e-141 469.8 11.3 1.0 1 0 0 1 1 1 1 ALG3 protein DUF2070 PF09843.9 EMD70043.1 - 1.6 6.9 5.1 2.5 6.3 5.1 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) HTH_Tnp_Tc5 PF03221.16 EMD70044.1 - 4.7e-09 36.1 0.1 9.6e-09 35.2 0.1 1.6 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_psq PF05225.16 EMD70044.1 - 0.0018 17.9 0.1 0.0029 17.3 0.1 1.3 1 0 0 1 1 1 1 helix-turn-helix, Psq domain Ribosomal_S13_N PF08069.12 EMD70044.1 - 0.02 14.9 0.1 0.067 13.3 0.0 1.9 2 0 0 2 2 2 0 Ribosomal S13/S15 N-terminal domain Drf_GBD PF06371.13 EMD70044.1 - 0.022 14.3 0.0 0.028 14.0 0.0 1.2 1 0 0 1 1 1 0 Diaphanous GTPase-binding Domain Cdc6_C PF09079.11 EMD70044.1 - 0.076 13.0 0.2 9.4 6.3 0.0 2.6 3 0 0 3 3 3 0 CDC6, C terminal winged helix domain HTH_24 PF13412.6 EMD70044.1 - 0.11 12.0 0.1 0.8 9.3 0.0 2.2 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding AltA1 PF16541.5 EMD70045.1 - 7.8e-10 39.6 0.0 1.2e-09 38.9 0.0 1.3 1 0 0 1 1 1 1 Alternaria alternata allergen 1 MOZ_SAS PF01853.18 EMD70046.1 - 4.6e-82 274.0 0.0 6.6e-82 273.5 0.0 1.2 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 EMD70046.1 - 6.3e-24 83.3 1.1 1.3e-23 82.3 1.1 1.6 1 0 0 1 1 1 1 MYST family zinc finger domain Tudor-knot PF11717.8 EMD70046.1 - 8.4e-24 83.2 0.4 1.6e-23 82.3 0.4 1.5 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Acetyltransf_7 PF13508.7 EMD70046.1 - 0.0015 18.9 0.0 0.0031 17.9 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain 5_3_exonuc_N PF02739.16 EMD70046.1 - 0.065 13.1 0.0 0.096 12.6 0.0 1.3 1 0 0 1 1 1 0 5'-3' exonuclease, N-terminal resolvase-like domain DUF1918 PF08940.11 EMD70046.1 - 0.091 12.4 0.0 0.22 11.2 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1918) Acetyltransf_1 PF00583.25 EMD70046.1 - 0.14 12.4 0.0 0.33 11.2 0.0 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family RNase_T PF00929.24 EMD70047.1 - 8e-19 68.8 0.0 1.2e-18 68.2 0.0 1.3 1 0 0 1 1 1 1 Exonuclease DNA_pol_A_exo1 PF01612.20 EMD70047.1 - 0.02 14.6 0.0 0.09 12.5 0.0 2.0 1 1 0 1 1 1 0 3'-5' exonuclease Aldo_ket_red PF00248.21 EMD70048.1 - 3.1e-65 220.3 0.0 3.6e-65 220.0 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family zf-MYND PF01753.18 EMD70049.1 - 5.7e-10 39.1 11.4 8.7e-10 38.5 11.4 1.3 1 0 0 1 1 1 1 MYND finger zf-C6H2 PF15801.5 EMD70049.1 - 0.099 13.0 6.5 0.19 12.0 6.5 1.4 1 0 0 1 1 1 0 zf-MYND-like zinc finger, mRNA-binding zf-Mss51 PF13824.6 EMD70049.1 - 1.1 9.4 7.0 2.9 8.1 7.0 1.6 1 1 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 Fer4_2 PF12797.7 EMD70049.1 - 2.3 8.5 5.4 38 4.7 0.0 2.6 2 0 0 2 2 2 0 4Fe-4S binding domain GATA PF00320.27 EMD70050.1 - 3.7e-30 103.2 15.4 1.7e-15 56.3 2.4 2.4 2 0 0 2 2 2 2 GATA zinc finger TF_Zn_Ribbon PF08271.12 EMD70050.1 - 1.3e-06 27.8 3.2 0.0023 17.4 0.2 2.4 2 0 0 2 2 2 2 TFIIB zinc-binding OrfB_Zn_ribbon PF07282.11 EMD70050.1 - 1.6e-05 24.7 2.8 0.0043 16.9 0.2 2.7 2 0 0 2 2 2 2 Putative transposase DNA-binding domain Zn-ribbon_8 PF09723.10 EMD70050.1 - 4.6e-05 23.4 1.4 0.1 12.8 0.1 2.8 2 0 0 2 2 2 2 Zinc ribbon domain TDP43_N PF18694.1 EMD70050.1 - 0.0014 18.5 0.0 0.35 10.7 0.0 2.4 2 0 0 2 2 2 1 Transactive response DNA-binding protein N-terminal domain Auto_anti-p27 PF06677.12 EMD70050.1 - 0.002 18.2 7.9 0.086 13.0 0.4 2.9 3 0 0 3 3 3 2 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) zf-RRN7 PF11781.8 EMD70050.1 - 0.0025 17.5 3.4 0.19 11.4 0.3 2.6 2 0 0 2 2 2 2 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 ArfGap PF01412.18 EMD70050.1 - 0.012 15.6 7.1 1.3 9.1 0.0 3.2 3 0 0 3 3 3 0 Putative GTPase activating protein for Arf DUF2387 PF09526.10 EMD70050.1 - 0.029 14.5 6.8 2.1 8.6 0.0 3.2 3 0 0 3 3 3 0 Probable metal-binding protein (DUF2387) eIF-5_eIF-2B PF01873.17 EMD70050.1 - 0.031 14.1 5.1 1.6 8.6 0.8 2.5 2 0 0 2 2 2 0 Domain found in IF2B/IF5 zf-Sec23_Sec24 PF04810.15 EMD70050.1 - 0.058 13.5 0.9 0.058 13.5 0.9 2.9 3 0 0 3 3 3 0 Sec23/Sec24 zinc finger Elf1 PF05129.13 EMD70050.1 - 0.12 12.5 1.0 6 7.0 0.1 2.7 2 0 0 2 2 2 0 Transcription elongation factor Elf1 like DZR PF12773.7 EMD70050.1 - 0.98 9.5 13.1 1.3 9.1 0.2 3.2 2 1 1 3 3 3 0 Double zinc ribbon FYVE PF01363.21 EMD70050.1 - 1.5 9.0 6.2 11 6.2 0.1 2.8 2 1 0 2 2 2 0 FYVE zinc finger COPI_assoc PF08507.10 EMD70051.1 - 4.1e-36 123.9 3.8 4.3e-36 123.8 3.8 1.0 1 0 0 1 1 1 1 COPI associated protein CBP_BcsF PF11120.8 EMD70051.1 - 0.05 13.7 1.1 2.7 8.2 0.1 2.3 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsF TMEM72 PF16054.5 EMD70051.1 - 0.19 11.4 1.7 7.3 6.2 0.3 2.1 1 1 1 2 2 2 0 Transmembrane protein family 72 DUF3096 PF11295.8 EMD70051.1 - 0.27 10.9 6.9 1 9.0 0.3 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3096) YtpI PF14007.6 EMD70051.1 - 6.5 7.0 9.8 0.44 10.7 4.0 1.9 1 1 1 2 2 2 0 YtpI-like protein Ses_B PF17046.5 EMD70053.1 - 0.0004 20.3 5.7 0.14 12.1 0.2 2.9 2 0 0 2 2 2 2 SesB domain on fungal death-pathway protein DUF2304 PF10066.9 EMD70053.1 - 4.9 7.4 8.1 2.1 8.6 3.7 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2304) zf-C2H2_4 PF13894.6 EMD70054.1 - 0.0018 18.9 12.1 0.12 13.3 1.9 3.6 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2 PF00096.26 EMD70054.1 - 0.0038 17.6 12.3 0.068 13.7 0.2 4.3 4 0 0 4 4 4 2 Zinc finger, C2H2 type zf_UBZ PF18439.1 EMD70054.1 - 0.044 13.4 2.9 3.1 7.5 0.6 2.5 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger ADK_lid PF05191.14 EMD70054.1 - 0.39 10.8 4.2 1.5 8.8 2.9 2.3 2 0 0 2 2 2 0 Adenylate kinase, active site lid RNA_pol_I_TF PF04090.12 EMD70055.1 - 0.14 11.6 0.0 0.72 9.3 0.0 1.9 2 0 0 2 2 2 0 RNA polymerase I specific initiation factor CAP_assoc_N PF14504.6 EMD70055.1 - 0.16 11.8 0.0 0.19 11.5 0.0 1.1 1 0 0 1 1 1 0 CAP-associated N-terminal Ras PF00071.22 EMD70058.1 - 3e-59 199.3 0.2 3.5e-59 199.0 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EMD70058.1 - 1.6e-20 73.5 0.0 3.1e-20 72.6 0.0 1.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EMD70058.1 - 7.5e-09 35.3 0.0 8.5e-09 35.1 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EMD70058.1 - 1.7e-06 27.7 0.2 9.3e-06 25.3 0.1 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EMD70058.1 - 8.2e-05 22.6 0.3 0.35 10.8 0.0 2.4 1 1 0 2 2 2 2 RsgA GTPase FeoB_N PF02421.18 EMD70058.1 - 0.00023 20.7 0.0 0.00035 20.1 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B MMR_HSR1 PF01926.23 EMD70058.1 - 0.0016 18.5 0.0 0.0032 17.5 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase MMR_HSR1_Xtn PF16897.5 EMD70058.1 - 0.002 18.1 0.0 0.0042 17.1 0.0 1.6 1 1 0 1 1 1 1 C-terminal region of MMR_HSR1 domain phiKZ_IP PF12699.7 EMD70058.1 - 0.05 12.8 0.0 0.07 12.3 0.0 1.1 1 0 0 1 1 1 0 phiKZ-like phage internal head proteins ATP_bind_1 PF03029.17 EMD70058.1 - 0.12 12.2 2.6 0.69 9.6 0.1 2.1 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein IstB_IS21 PF01695.17 EMD70058.1 - 0.37 10.5 1.0 2.5 7.8 0.1 2.1 1 1 1 2 2 2 0 IstB-like ATP binding protein MoCF_biosynth PF00994.24 EMD70059.1 - 8.9e-36 122.7 0.0 1.4e-35 122.1 0.0 1.3 1 0 0 1 1 1 1 Probable molybdopterin binding domain Cofilin_ADF PF00241.20 EMD70060.1 - 1.5e-18 66.8 0.0 1.8e-18 66.5 0.0 1.1 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein DUF4385 PF14328.6 EMD70061.1 - 1.8e-55 187.0 2.3 2.4e-55 186.6 2.3 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4385) DUF5081 PF16887.5 EMD70061.1 - 0.092 11.8 0.0 0.14 11.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5081) COA2 PF17051.5 EMD70062.1 - 9.4e-05 22.4 0.1 0.00016 21.7 0.1 1.4 1 1 0 1 1 1 1 Cytochrome C oxidase assembly factor 2 Metallophos PF00149.28 EMD70063.1 - 3.4e-32 112.6 0.0 4.4e-23 82.8 0.0 2.2 2 0 0 2 2 2 2 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EMD70063.1 - 0.073 13.5 0.1 0.18 12.3 0.1 1.7 1 0 0 1 1 1 0 Serine-threonine protein phosphatase N-terminal domain MFS_1 PF07690.16 EMD70064.1 - 5.4e-31 107.8 37.5 5.4e-31 107.8 37.5 1.6 1 1 1 2 2 2 1 Major Facilitator Superfamily Saf_2TM PF18303.1 EMD70064.1 - 4.3 6.9 5.5 4 7.0 0.7 2.6 2 0 0 2 2 2 0 SAVED-fused 2TM effector domain PTR2 PF00854.21 EMD70065.1 - 4.8e-83 279.2 5.2 6.4e-83 278.8 5.2 1.1 1 0 0 1 1 1 1 POT family Ank_5 PF13857.6 EMD70066.1 - 0.009 16.3 0.0 0.016 15.5 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 EMD70066.1 - 0.032 14.8 0.0 0.07 13.7 0.0 1.6 2 0 0 2 2 2 0 Ankyrin repeats (many copies) Glyco_hydro_18 PF00704.28 EMD70067.1 - 4.4e-13 49.7 0.0 4.9e-13 49.5 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 NolX PF05819.11 EMD70067.1 - 0.11 11.8 0.0 0.13 11.5 0.0 1.1 1 0 0 1 1 1 0 NolX protein HNH_5 PF14279.6 EMD70068.1 - 0.082 12.8 0.1 0.24 11.3 0.1 1.7 1 0 0 1 1 1 0 HNH endonuclease Abhydrolase_6 PF12697.7 EMD70069.1 - 2.4e-13 51.2 0.4 3.3e-13 50.8 0.4 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EMD70069.1 - 1.9e-08 33.9 0.2 2.7e-08 33.4 0.2 1.4 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EMD70069.1 - 0.013 15.2 5.2 0.099 12.3 5.0 2.1 1 1 0 1 1 1 0 alpha/beta hydrolase fold Aft1_HRA PF11786.8 EMD70070.1 - 3.3e-21 75.4 10.1 3.3e-21 75.4 10.1 3.1 3 1 1 4 4 4 1 Aft1 HRA domain Aft1_HRR PF11787.8 EMD70070.1 - 3.3e-16 60.2 12.0 3.3e-16 60.2 12.0 4.2 3 2 0 3 3 3 1 Aft1 HRR domain Aft1_OSA PF11785.8 EMD70070.1 - 1.4e-15 57.4 8.6 1.4e-15 57.4 8.6 3.9 3 0 0 3 3 3 1 Aft1 osmotic stress response (OSM) domain bZIP_1 PF00170.21 EMD70070.1 - 1.1e-12 47.8 5.3 1.9e-12 47.1 5.3 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 EMD70070.1 - 3.4e-05 23.8 5.7 6.6e-05 22.9 5.7 1.5 1 0 0 1 1 1 1 Basic region leucine zipper TFIIA PF03153.13 EMD70070.1 - 0.0026 17.8 18.7 0.0026 17.8 18.7 2.1 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit bZIP_Maf PF03131.17 EMD70070.1 - 0.0035 17.8 4.4 0.011 16.2 4.4 1.8 1 0 0 1 1 1 1 bZIP Maf transcription factor PBP1_TM PF14812.6 EMD70070.1 - 2.4 8.6 9.7 6.4 7.2 9.7 1.7 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Transthyretin PF00576.21 EMD70072.1 - 8.3e-37 126.2 0.1 9.6e-37 126.0 0.1 1.0 1 0 0 1 1 1 1 HIUase/Transthyretin family MG4 PF17789.1 EMD70072.1 - 0.1 12.8 0.0 0.14 12.3 0.0 1.4 1 0 0 1 1 1 0 Macroglobulin domain MG4 CarboxypepD_reg PF13620.6 EMD70072.1 - 0.34 11.2 3.3 1.2 9.5 3.3 1.9 1 1 0 1 1 1 0 Carboxypeptidase regulatory-like domain Opy2 PF09463.10 EMD70073.1 - 3.4e-05 24.1 16.9 5.5e-05 23.4 16.9 1.4 1 0 0 1 1 1 1 Opy2 protein Ras PF00071.22 EMD70075.1 - 3.6e-17 62.4 0.0 1e-16 61.0 0.0 1.7 1 1 0 1 1 1 1 Ras family Roc PF08477.13 EMD70075.1 - 0.00021 21.5 0.0 0.002 18.3 0.0 2.2 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MCM PF00493.23 EMD70075.1 - 0.057 12.5 0.0 0.09 11.9 0.0 1.3 1 0 0 1 1 1 0 MCM P-loop domain G-alpha PF00503.20 EMD70075.1 - 0.11 11.7 0.0 0.18 10.9 0.0 1.3 1 0 0 1 1 1 0 G-protein alpha subunit AAA_29 PF13555.6 EMD70075.1 - 0.12 12.2 0.0 0.26 11.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Peptidase_M14 PF00246.24 EMD70076.1 - 5.6e-42 144.5 1.0 8e-42 144.0 1.0 1.2 1 0 0 1 1 1 1 Zinc carboxypeptidase HET PF06985.11 EMD70077.1 - 3.2e-27 95.7 0.0 5.2e-27 95.0 0.0 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Pribosyl_synth PF14572.6 EMD70078.1 - 3.1e-40 138.2 2.3 2.9e-35 122.0 0.9 2.3 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.6 EMD70078.1 - 4.8e-35 120.0 0.0 1.1e-34 118.8 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.27 EMD70078.1 - 1.8e-14 53.6 0.4 3.6e-14 52.6 0.1 1.6 2 0 0 2 2 2 1 Phosphoribosyl transferase domain UPRTase PF14681.6 EMD70078.1 - 0.013 15.0 0.1 0.021 14.3 0.1 1.2 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase ICL PF00463.21 EMD70080.1 - 6.9e-299 991.7 3.1 7.8e-299 991.5 3.1 1.0 1 0 0 1 1 1 1 Isocitrate lyase family PEP_mutase PF13714.6 EMD70080.1 - 8.3e-12 45.1 0.1 1.4e-10 41.0 0.0 2.3 2 0 0 2 2 2 1 Phosphoenolpyruvate phosphomutase DUF2554 PF10829.8 EMD70080.1 - 0.036 14.5 0.2 1 9.8 0.1 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2554) Fae PF08714.11 EMD70080.1 - 0.061 13.3 0.0 0.14 12.1 0.0 1.6 1 0 0 1 1 1 0 Formaldehyde-activating enzyme (Fae) DUF1365 PF07103.11 EMD70081.1 - 1.1e-55 188.9 0.0 1.5e-55 188.5 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1365) RasGAP PF00616.19 EMD70083.1 - 4.8e-31 108.1 11.4 6.1e-30 104.5 0.0 4.3 4 1 0 4 4 4 1 GTPase-activator protein for Ras-like GTPase C2 PF00168.30 EMD70083.1 - 1.4e-05 25.3 0.0 0.00032 20.9 0.0 2.4 2 0 0 2 2 2 1 C2 domain PH PF00169.29 EMD70083.1 - 4e-05 24.1 0.0 0.088 13.3 0.0 3.0 2 0 0 2 2 2 2 PH domain RPN2_C PF18004.1 EMD70083.1 - 0.77 9.7 6.6 2.2 8.2 6.6 1.7 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Pro_isomerase PF00160.21 EMD70084.1 - 2.4e-47 161.1 0.3 3.8e-47 160.5 0.3 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_2 PF07719.17 EMD70084.1 - 3.2e-05 23.7 13.0 0.0096 16.0 2.8 3.7 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_12 PF13424.6 EMD70084.1 - 8e-05 22.9 1.9 0.0016 18.7 1.7 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 EMD70084.1 - 8.2e-05 22.3 14.1 0.05 13.4 2.0 3.8 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 EMD70084.1 - 0.057 13.7 13.7 0.11 12.8 0.9 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_11 PF13414.6 EMD70084.1 - 0.13 11.9 8.7 1.1 9.0 0.1 3.8 2 1 1 3 3 3 0 TPR repeat TPR_14 PF13428.6 EMD70084.1 - 0.35 11.8 4.0 1.9 9.5 2.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 EMD70084.1 - 0.53 10.8 5.9 0.4 11.2 4.0 1.7 2 0 0 2 2 2 0 Tetratricopeptide repeat IFRD PF05004.13 EMD70085.1 - 7.8e-82 274.8 13.7 1.3e-81 274.1 13.7 1.3 1 0 0 1 1 1 1 Interferon-related developmental regulator (IFRD) Ku_PK_bind PF08785.11 EMD70085.1 - 0.036 14.2 0.1 0.097 12.8 0.1 1.7 1 0 0 1 1 1 0 Ku C terminal domain like zf-C2H2 PF00096.26 EMD70087.1 - 0.00029 21.1 9.5 0.048 14.1 3.0 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EMD70087.1 - 2.7 9.1 7.0 8.5 7.5 0.5 2.9 2 0 0 2 2 2 0 C2H2-type zinc finger Not3 PF04065.15 EMD70088.1 - 1.5e-88 296.2 32.9 1.6e-88 296.0 31.7 1.6 2 0 0 2 2 2 1 Not1 N-terminal domain, CCR4-Not complex component NOT2_3_5 PF04153.18 EMD70088.1 - 3.8e-43 146.7 11.8 1.1e-42 145.3 11.8 1.8 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family DUF2373 PF10180.9 EMD70088.1 - 0.004 16.9 2.4 0.01 15.7 2.4 1.6 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2373) Chal_sti_synt_C PF02797.15 EMD70088.1 - 0.047 13.7 0.0 0.097 12.7 0.0 1.4 1 0 0 1 1 1 0 Chalcone and stilbene synthases, C-terminal domain CorA PF01544.18 EMD70088.1 - 0.078 12.3 6.9 0.029 13.7 3.6 1.8 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein DUF948 PF06103.11 EMD70088.1 - 0.17 12.1 3.8 0.3 11.4 1.2 2.6 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF1192 PF06698.11 EMD70088.1 - 0.66 10.1 7.6 0.16 12.1 0.5 3.4 4 0 0 4 4 4 0 Protein of unknown function (DUF1192) T3SS_basalb_I PF17001.5 EMD70088.1 - 0.71 10.5 7.9 6.2 7.5 2.3 3.3 1 1 1 2 2 2 0 Type III secretion basal body protein I, YscI, HrpB, PscI FlaC_arch PF05377.11 EMD70088.1 - 1.8 9.0 14.8 5.4 7.5 2.0 4.3 4 0 0 4 4 4 0 Flagella accessory protein C (FlaC) Syntaxin_2 PF14523.6 EMD70088.1 - 4.8 7.6 17.7 0.1 13.0 2.0 3.0 3 0 0 3 3 3 0 Syntaxin-like protein Tyr_Deacylase PF02580.16 EMD70089.1 - 2.2e-52 177.4 0.0 2.6e-52 177.2 0.0 1.0 1 0 0 1 1 1 1 D-Tyr-tRNA(Tyr) deacylase DUF2914 PF11141.8 EMD70089.1 - 0.021 14.5 0.0 0.04 13.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2914) ABC_membrane PF00664.23 EMD70090.1 - 3.9e-102 341.6 39.6 5.1e-55 187.0 18.6 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EMD70090.1 - 2.4e-68 228.9 0.0 8.6e-33 113.8 0.0 2.6 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EMD70090.1 - 1.1e-14 54.4 6.3 1.3e-05 24.8 2.6 4.5 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 EMD70090.1 - 3.1e-08 34.0 0.7 0.0013 19.0 0.0 3.6 2 2 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EMD70090.1 - 5.9e-08 33.3 3.9 0.0046 17.4 0.1 3.2 2 2 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.6 EMD70090.1 - 8.3e-08 31.9 0.4 0.011 15.4 0.1 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_21 PF13304.6 EMD70090.1 - 5.8e-07 29.6 0.2 0.056 13.2 0.0 4.2 3 1 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_18 PF13238.6 EMD70090.1 - 1.3e-05 25.8 0.0 0.06 13.9 0.0 2.7 2 0 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 EMD70090.1 - 4.4e-05 23.5 0.1 0.51 10.2 0.1 2.7 2 0 0 2 2 2 2 RsgA GTPase G-alpha PF00503.20 EMD70090.1 - 4.4e-05 22.8 0.0 0.069 12.3 0.0 2.3 2 0 0 2 2 2 2 G-protein alpha subunit AAA_15 PF13175.6 EMD70090.1 - 5.3e-05 23.1 1.0 0.075 12.7 0.0 2.6 3 0 0 3 3 2 2 AAA ATPase domain AAA_30 PF13604.6 EMD70090.1 - 5.7e-05 22.9 3.2 0.055 13.2 0.1 3.7 4 1 0 4 4 4 2 AAA domain AAA_28 PF13521.6 EMD70090.1 - 0.00025 21.3 0.0 0.42 10.9 0.0 2.7 2 0 0 2 2 2 2 AAA domain Zeta_toxin PF06414.12 EMD70090.1 - 0.00026 20.3 0.3 0.23 10.7 0.0 2.8 3 0 0 3 3 2 2 Zeta toxin AAA_5 PF07728.14 EMD70090.1 - 0.00043 20.3 0.1 2.3 8.2 0.0 3.3 3 0 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 EMD70090.1 - 0.00047 20.3 0.4 1.2 9.3 0.0 2.9 3 0 0 3 3 2 2 AAA domain Ploopntkinase3 PF18751.1 EMD70090.1 - 0.0011 18.9 0.1 0.58 10.1 0.0 2.6 2 0 0 2 2 2 1 P-loop Nucleotide Kinase3 DUF87 PF01935.17 EMD70090.1 - 0.0011 19.1 1.8 1.9 8.6 0.0 3.1 3 0 0 3 3 2 2 Helicase HerA, central domain ABC_ATPase PF09818.9 EMD70090.1 - 0.0012 17.7 7.6 0.044 12.6 0.1 3.3 5 0 0 5 5 4 2 Predicted ATPase of the ABC class AAA_25 PF13481.6 EMD70090.1 - 0.0015 18.1 0.0 2.2 7.8 0.0 2.7 2 0 0 2 2 2 2 AAA domain PRK PF00485.18 EMD70090.1 - 0.0018 18.1 0.0 0.16 11.7 0.0 2.6 2 0 0 2 2 2 1 Phosphoribulokinase / Uridine kinase family APS_kinase PF01583.20 EMD70090.1 - 0.0045 16.9 0.1 2.2 8.2 0.0 2.6 2 0 0 2 2 2 1 Adenylylsulphate kinase SbcCD_C PF13558.6 EMD70090.1 - 0.0057 16.9 3.8 3.1 8.1 0.4 4.0 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_24 PF13479.6 EMD70090.1 - 0.009 15.7 0.2 6.7 6.4 0.1 2.9 2 1 0 2 2 2 0 AAA domain AAA_7 PF12775.7 EMD70090.1 - 0.012 15.2 0.1 4.4 6.8 0.0 2.5 2 0 0 2 2 2 0 P-loop containing dynein motor region MMR_HSR1 PF01926.23 EMD70090.1 - 0.013 15.6 0.0 6 7.0 0.0 2.9 2 0 0 2 2 2 0 50S ribosome-binding GTPase NB-ARC PF00931.22 EMD70090.1 - 0.015 14.5 0.3 2.2 7.4 0.0 2.3 2 0 0 2 2 2 0 NB-ARC domain RNA_helicase PF00910.22 EMD70090.1 - 0.026 14.9 0.0 4 7.9 0.0 2.9 2 0 0 2 2 2 0 RNA helicase CPT PF07931.12 EMD70090.1 - 0.046 13.6 0.1 13 5.5 0.1 2.5 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein AAA_23 PF13476.6 EMD70090.1 - 0.075 13.5 4.6 3.3 8.2 0.1 2.8 3 0 0 3 3 2 0 AAA domain TruB_C PF09142.11 EMD70090.1 - 0.076 12.8 0.1 6.4 6.6 0.0 2.7 2 0 0 2 2 2 0 tRNA Pseudouridine synthase II, C terminal AAA_17 PF13207.6 EMD70090.1 - 0.077 13.4 0.1 6.1 7.3 0.0 2.9 3 0 0 3 3 2 0 AAA domain FtsK_SpoIIIE PF01580.18 EMD70090.1 - 0.087 12.2 2.2 5.2 6.3 0.1 2.5 2 0 0 2 2 2 0 FtsK/SpoIIIE family Dala_Dala_lig_N PF01820.21 EMD70090.1 - 0.1 13.1 0.0 23 5.5 0.0 2.7 2 0 0 2 2 2 0 D-ala D-ala ligase N-terminus ATP_bind_1 PF03029.17 EMD70090.1 - 0.13 12.0 0.2 18 5.0 0.0 2.4 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein Rad17 PF03215.15 EMD70090.1 - 0.19 11.6 0.0 4.8 7.1 0.0 2.4 2 0 0 2 2 2 0 Rad17 P-loop domain NACHT PF05729.12 EMD70090.1 - 0.19 11.6 1.1 16 5.4 0.0 2.7 2 0 0 2 2 2 0 NACHT domain Lipocalin_2 PF08212.12 EMD70092.1 - 1.2e-15 57.7 0.0 1.5e-15 57.3 0.0 1.1 1 0 0 1 1 1 1 Lipocalin-like domain Hemerythrin PF01814.23 EMD70094.1 - 2e-10 41.4 0.4 4.3e-10 40.3 0.7 1.4 1 1 0 1 1 1 1 Hemerythrin HHE cation binding domain Actin PF00022.19 EMD70095.1 - 4.7e-126 420.7 0.0 2.3e-125 418.4 0.0 1.8 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EMD70095.1 - 0.0011 17.8 0.0 0.017 14.0 0.0 2.5 1 1 0 1 1 1 1 MreB/Mbl protein DUF3602 PF12223.8 EMD70096.1 - 4.8e-21 75.1 10.8 5.2e-19 68.6 0.9 2.6 2 1 1 3 3 3 2 Protein of unknown function (DUF3602) IMUP PF15761.5 EMD70096.1 - 0.016 15.9 3.1 0.031 15.0 3.1 1.5 1 0 0 1 1 1 0 Immortalisation up-regulated protein SH2_2 PF14633.6 EMD70097.1 - 1.2e-79 266.7 0.1 1.2e-79 266.7 0.1 2.2 2 0 0 2 2 1 1 SH2 domain YqgF PF14639.6 EMD70097.1 - 9e-39 132.7 0.2 1.7e-37 128.5 0.0 2.5 2 0 0 2 2 2 1 Holliday-junction resolvase-like of SPT6 HTH_44 PF14641.6 EMD70097.1 - 6.2e-32 110.4 0.2 1.8e-31 108.9 0.2 1.8 1 0 0 1 1 1 1 Helix-turn-helix DNA-binding domain of SPT6 HHH_7 PF14635.6 EMD70097.1 - 2.1e-28 98.7 0.0 6.7e-28 97.1 0.0 1.9 2 0 0 2 2 2 1 Helix-hairpin-helix motif SPT6_acidic PF14632.6 EMD70097.1 - 6.4e-17 61.9 30.2 6.4e-17 61.9 30.2 4.4 5 0 0 5 5 4 1 Acidic N-terminal SPT6 HHH_9 PF17674.1 EMD70097.1 - 7.2e-05 23.6 0.9 7.2e-05 23.6 0.9 3.7 2 1 0 2 2 2 1 HHH domain SH2 PF00017.24 EMD70097.1 - 0.00011 22.2 0.0 0.00029 20.9 0.0 1.7 1 0 0 1 1 1 1 SH2 domain Tex_YqgF PF16921.5 EMD70097.1 - 0.015 15.7 0.0 0.034 14.6 0.0 1.6 1 0 0 1 1 1 0 Tex protein YqgF-like domain SOAR PF16533.5 EMD70097.1 - 0.017 15.1 0.1 0.11 12.5 0.1 2.4 1 0 0 1 1 1 0 STIM1 Orai1-activating region HHH_3 PF12836.7 EMD70097.1 - 0.033 14.4 0.1 0.19 12.0 0.0 2.4 3 0 0 3 3 3 0 Helix-hairpin-helix motif NBD94 PF16830.5 EMD70097.1 - 0.043 14.2 2.9 0.077 13.4 1.3 2.3 3 0 0 3 3 1 0 Nucleotide-Binding Domain 94 of RH ICA69 PF04629.14 EMD70097.1 - 0.24 11.7 10.5 0.62 10.3 10.5 1.7 1 0 0 1 1 1 0 Islet cell autoantigen ICA69, C-terminal domain CP12 PF02672.15 EMD70097.1 - 0.34 11.7 5.9 0.98 10.2 0.1 3.7 4 0 0 4 4 3 0 CP12 domain Pkinase PF00069.25 EMD70098.1 - 7.8e-66 222.1 0.0 9.5e-66 221.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD70098.1 - 1.3e-38 132.7 0.0 1.8e-38 132.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EMD70098.1 - 0.0015 17.6 0.1 0.0034 16.4 0.0 1.5 2 0 0 2 2 2 1 Haspin like kinase domain Pkinase_fungal PF17667.1 EMD70098.1 - 0.0029 16.4 0.0 0.0049 15.7 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EMD70098.1 - 0.012 15.5 0.0 0.057 13.3 0.0 1.9 1 1 0 2 2 2 0 Phosphotransferase enzyme family Kinase-like PF14531.6 EMD70098.1 - 0.019 14.3 0.1 0.06 12.6 0.0 1.8 2 1 0 2 2 2 0 Kinase-like RIO1 PF01163.22 EMD70098.1 - 0.093 12.3 0.1 0.2 11.3 0.0 1.5 2 0 0 2 2 2 0 RIO1 family F-box-like PF12937.7 EMD70099.1 - 0.0057 16.5 0.2 0.018 14.9 0.0 1.9 1 1 1 2 2 2 1 F-box-like F-box PF00646.33 EMD70099.1 - 0.1 12.5 0.0 0.28 11.1 0.0 1.8 2 0 0 2 2 2 0 F-box domain Pkinase PF00069.25 EMD70100.1 - 3.5e-14 52.8 0.0 7.1e-14 51.8 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD70100.1 - 9.8e-07 28.3 0.0 1.5e-06 27.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Solute_trans_a PF03619.16 EMD70101.1 - 1.9e-55 188.2 12.0 2.4e-55 187.9 12.0 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha DUF4079 PF13301.6 EMD70101.1 - 0.019 15.1 3.3 0.044 13.9 3.3 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF4079) TT_ORF1 PF02956.14 EMD70101.1 - 0.23 10.1 0.1 0.34 9.5 0.1 1.2 1 0 0 1 1 1 0 TT viral orf 1 SPC12 PF06645.13 EMD70101.1 - 1.6 8.8 8.6 0.29 11.2 1.1 2.7 2 1 0 2 2 2 0 Microsomal signal peptidase 12 kDa subunit (SPC12) SLATT_fungal PF18142.1 EMD70101.1 - 2.3 8.2 3.7 5 7.1 0.7 2.3 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain Cpn60_TCP1 PF00118.24 EMD70102.1 - 1.3e-170 568.3 4.7 1.4e-170 568.1 4.7 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family NusA_N PF08529.11 EMD70102.1 - 0.1 13.0 3.4 0.41 11.0 3.4 2.3 1 1 0 1 1 1 0 NusA N-terminal domain PLDc PF00614.22 EMD70105.1 - 4.2e-17 61.5 0.6 2e-07 30.9 0.0 2.6 2 0 0 2 2 2 2 Phospholipase D Active site motif PLDc_2 PF13091.6 EMD70105.1 - 4.9e-13 49.1 0.0 1.2e-07 31.6 0.0 2.8 2 1 0 2 2 2 2 PLD-like domain PX PF00787.24 EMD70105.1 - 5.6e-11 42.4 0.0 2.4e-10 40.4 0.0 2.2 2 0 0 2 2 2 1 PX domain Hydrolase_4 PF12146.8 EMD70106.1 - 0.016 14.5 0.1 0.072 12.3 0.1 2.1 1 1 0 1 1 1 0 Serine aminopeptidase, S33 MFS_1 PF07690.16 EMD70112.1 - 6.4e-34 117.4 53.6 4.2e-32 111.5 33.0 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily UPF0182 PF03699.13 EMD70112.1 - 0.029 12.5 0.1 0.047 11.8 0.1 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0182) F-box-like PF12937.7 EMD70113.1 - 3.6e-06 26.8 0.1 1.1e-05 25.3 0.1 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EMD70113.1 - 0.0016 18.2 0.0 0.0054 16.6 0.0 2.0 1 0 0 1 1 1 1 F-box domain MFS_1 PF07690.16 EMD70114.1 - 7e-33 114.0 28.5 9.8e-33 113.5 28.5 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily EPSP_synthase PF00275.20 EMD70115.1 - 1.2e-125 419.5 0.0 1.7e-125 419.0 0.0 1.2 1 0 0 1 1 1 1 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) DHQ_synthase PF01761.20 EMD70115.1 - 6.2e-101 337.0 0.0 9.5e-101 336.4 0.0 1.3 1 0 0 1 1 1 1 3-dehydroquinate synthase DHquinase_I PF01487.15 EMD70115.1 - 1.4e-55 189.1 0.0 3e-55 188.0 0.0 1.6 2 0 0 2 2 2 1 Type I 3-dehydroquinase SKI PF01202.22 EMD70115.1 - 5.4e-37 127.3 0.0 5.5e-36 124.1 0.0 2.4 3 0 0 3 3 3 1 Shikimate kinase Shikimate_dh_N PF08501.11 EMD70115.1 - 7.2e-22 77.5 0.0 1.6e-21 76.4 0.0 1.6 1 0 0 1 1 1 1 Shikimate dehydrogenase substrate binding domain SDH_C PF18317.1 EMD70115.1 - 9.7e-10 38.1 0.0 2.5e-09 36.7 0.0 1.8 1 0 0 1 1 1 1 Shikimate 5'-dehydrogenase C-terminal domain Fe-ADH_2 PF13685.6 EMD70115.1 - 1.2e-06 28.4 0.0 2.7e-06 27.3 0.0 1.6 1 1 0 1 1 1 1 Iron-containing alcohol dehydrogenase AAA_33 PF13671.6 EMD70115.1 - 0.023 14.9 0.0 0.057 13.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain Shikimate_DH PF01488.20 EMD70115.1 - 0.036 14.1 0.0 0.1 12.6 0.0 1.7 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Iso_dh PF00180.20 EMD70117.1 - 4.9e-76 256.1 0.0 5.8e-76 255.9 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Wzy_C PF04932.15 EMD70118.1 - 0.29 10.8 2.6 0.27 10.8 0.1 2.1 2 0 0 2 2 2 0 O-Antigen ligase VIT PF08487.10 EMD70119.1 - 4.9e-36 123.3 1.7 8.9e-36 122.5 0.1 2.3 3 0 0 3 3 3 1 Vault protein inter-alpha-trypsin domain VWA_3 PF13768.6 EMD70119.1 - 2.3e-29 102.4 0.0 3.7e-29 101.7 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VIT_2 PF13757.6 EMD70119.1 - 9.2e-15 54.3 0.0 2.3e-14 53.0 0.0 1.7 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VWA PF00092.28 EMD70119.1 - 1.3e-14 54.8 0.0 2.2e-14 54.1 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 EMD70119.1 - 2.2e-09 37.9 0.0 4.9e-09 36.8 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_CoxE PF05762.14 EMD70119.1 - 0.0014 18.1 0.0 0.0031 16.9 0.0 1.5 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein PseudoU_synth_1 PF01416.20 EMD70120.1 - 1e-31 109.6 0.0 2.3e-30 105.2 0.0 2.4 2 0 0 2 2 2 1 tRNA pseudouridine synthase ubiquitin PF00240.23 EMD70121.1 - 0.00021 20.9 0.0 0.00022 20.9 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin family YukD PF08817.10 EMD70121.1 - 0.067 13.9 0.0 0.09 13.5 0.0 1.3 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukD Peptidase_S9 PF00326.21 EMD70121.1 - 0.18 11.2 0.0 0.22 10.9 0.0 1.1 1 0 0 1 1 1 0 Prolyl oligopeptidase family DIM1 PF02966.16 EMD70122.1 - 8e-69 229.5 0.1 9.1e-69 229.4 0.1 1.0 1 0 0 1 1 1 1 Mitosis protein DIM1 Ribosomal_L35Ae PF01247.18 EMD70123.1 - 3.7e-40 136.0 0.1 4.3e-40 135.8 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein L35Ae RimM PF01782.18 EMD70123.1 - 0.0067 16.6 0.0 4.5 7.6 0.0 2.1 2 0 0 2 2 2 2 RimM N-terminal domain vATP-synt_AC39 PF01992.16 EMD70124.1 - 8e-105 351.0 0.0 8.9e-105 350.9 0.0 1.0 1 0 0 1 1 1 1 ATP synthase (C/AC39) subunit UL16 PF17622.2 EMD70124.1 - 0.16 11.6 0.2 0.44 10.2 0.0 1.7 2 0 0 2 2 2 0 Viral unique long protein 16 zf-C2H2_2 PF12756.7 EMD70126.1 - 5.5e-25 87.7 1.9 4.9e-21 75.0 0.6 2.3 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) YL1 PF05764.13 EMD70126.1 - 1.6e-05 25.2 3.0 1.6e-05 25.2 3.0 1.6 2 0 0 2 2 2 1 YL1 nuclear protein zf-C2H2_jaz PF12171.8 EMD70126.1 - 0.0045 17.2 3.4 0.25 11.7 0.2 2.8 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.26 EMD70126.1 - 0.025 15.0 0.5 0.025 15.0 0.5 3.0 3 0 0 3 3 3 0 Zinc finger, C2H2 type AP-5_subunit_s1 PF15001.6 EMD70126.1 - 0.44 10.5 3.0 0.19 11.7 0.6 1.6 2 0 0 2 2 2 0 AP-5 complex subunit sigma-1 zf-C2H2_4 PF13894.6 EMD70126.1 - 2.7 9.1 13.1 1.4 10.0 0.4 3.5 3 0 0 3 3 3 0 C2H2-type zinc finger DARPP-32 PF05395.12 EMD70126.1 - 2.9 8.1 12.3 5.8 7.1 4.1 2.3 2 0 0 2 2 2 0 Protein phosphatase inhibitor 1/DARPP-32 FHA PF00498.26 EMD70127.1 - 1.7e-13 50.7 0.0 3e-13 49.9 0.0 1.4 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 EMD70127.1 - 0.0029 17.9 0.0 0.0078 16.5 0.0 1.6 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain RNA_pol_Rpb1_1 PF04997.12 EMD70128.1 - 3.4e-82 276.3 0.0 5.2e-82 275.7 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_5 PF04998.17 EMD70128.1 - 9.3e-82 274.4 0.1 1.4e-81 273.8 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 EMD70128.1 - 3.5e-70 235.5 0.0 6.7e-70 234.6 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 EMD70128.1 - 2.6e-34 118.4 0.0 8.7e-34 116.7 0.0 1.9 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 EMD70128.1 - 5.2e-27 93.9 0.0 2e-26 92.1 0.0 2.1 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 4 Zea_mays_MuDR PF05928.11 EMD70128.1 - 0.14 11.8 0.1 0.5 10.0 0.0 1.9 2 0 0 2 2 2 0 Zea mays MURB-like protein (MuDR) Ank_2 PF12796.7 EMD70129.1 - 1.5e-27 96.0 2.2 1.4e-07 32.0 0.0 4.2 2 2 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EMD70129.1 - 2e-23 82.4 4.0 9e-09 35.7 0.1 6.4 3 2 4 7 7 7 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EMD70129.1 - 4.9e-21 72.6 3.9 0.00039 20.6 0.0 7.7 8 0 0 8 8 8 5 Ankyrin repeat Ank PF00023.30 EMD70129.1 - 1.4e-19 69.6 9.1 0.0013 19.1 0.0 8.7 9 0 0 9 9 9 4 Ankyrin repeat Ank_5 PF13857.6 EMD70129.1 - 6e-15 55.1 4.2 3.1e-05 24.1 0.0 6.2 3 1 3 6 6 6 4 Ankyrin repeats (many copies) ZZ PF00569.17 EMD70129.1 - 1.9e-06 27.6 3.3 2e-06 27.5 0.4 2.2 2 0 0 2 2 2 1 Zinc finger, ZZ type SpoU_sub_bind PF08032.12 EMD70129.1 - 0.13 12.5 0.1 40 4.6 0.0 3.5 4 0 0 4 4 4 0 RNA 2'-O ribose methyltransferase substrate binding Beta-lactamase PF00144.24 EMD70131.1 - 5.5e-29 101.4 0.4 8.5e-29 100.8 0.4 1.3 1 0 0 1 1 1 1 Beta-lactamase BTRD1 PF17660.1 EMD70131.1 - 5.7e-27 93.3 0.9 1.3e-09 37.7 0.1 3.4 3 0 0 3 3 3 3 Bacterial tandem repeat domain 1 Ribosomal_S13_N PF08069.12 EMD70131.1 - 0.046 13.8 0.0 0.15 12.2 0.0 1.8 1 0 0 1 1 1 0 Ribosomal S13/S15 N-terminal domain SNF2_N PF00176.23 EMD70133.1 - 2.1e-21 76.0 0.0 2.3e-21 75.9 0.0 1.0 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EMD70134.1 - 1.6e-08 34.9 0.0 4.6e-08 33.4 0.0 1.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain CRPA PF05745.11 EMD70134.1 - 0.067 13.2 0.1 0.095 12.7 0.1 1.4 1 0 0 1 1 1 0 Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA) cNMP_binding PF00027.29 EMD70136.1 - 7.6e-41 138.1 0.0 1.1e-19 70.3 0.0 2.6 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain RIIa PF02197.17 EMD70136.1 - 2.6e-09 36.6 0.1 6.1e-09 35.4 0.1 1.6 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit CTXphi_pIII-N1 PF16710.5 EMD70136.1 - 5.4 7.2 4.8 7.1 6.8 0.4 2.3 2 0 0 2 2 2 0 N-terminal N1 domain of Vibrio phage CTXphi pIII AMPK1_CBM PF16561.5 EMD70137.1 - 8.4e-22 77.2 1.2 1.6e-21 76.3 1.2 1.4 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase CBM_48 PF02922.18 EMD70137.1 - 0.00066 20.0 0.3 0.051 13.9 0.2 2.4 2 0 0 2 2 2 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) CBM53 PF16760.5 EMD70137.1 - 0.015 15.9 0.9 0.032 14.8 0.9 1.5 1 0 0 1 1 1 0 Starch/carbohydrate-binding module (family 53) Molybdopterin_N PF18364.1 EMD70137.1 - 2.8 8.0 5.6 3.4 7.8 0.2 3.5 3 0 0 3 3 3 0 Molybdopterin oxidoreductase N-terminal domain HTH_56 PF18662.1 EMD70138.1 - 0.036 14.1 1.3 0.039 14.0 0.3 1.6 2 0 0 2 2 2 0 Cch helix turn helix domain HET PF06985.11 EMD70139.1 - 1e-24 87.6 0.3 1.8e-24 86.7 0.3 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Lactamase_B PF00753.27 EMD70140.1 - 2.5e-09 37.4 0.2 7.1e-09 36.0 0.0 1.8 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily Glyco_hydro_38N PF01074.22 EMD70140.1 - 0.061 12.7 0.0 0.15 11.4 0.0 1.6 2 0 0 2 2 2 0 Glycosyl hydrolases family 38 N-terminal domain Lactamase_B_2 PF12706.7 EMD70140.1 - 0.078 12.5 0.1 0.28 10.7 0.0 2.0 2 1 0 2 2 2 0 Beta-lactamase superfamily domain WD40 PF00400.32 EMD70142.1 - 2.5e-91 297.1 59.9 1.1e-09 38.8 0.4 11.9 11 0 0 11 11 11 11 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD70142.1 - 9.8e-28 96.3 15.1 0.00061 20.0 0.1 10.0 1 1 10 11 11 11 9 Anaphase-promoting complex subunit 4 WD40 domain NACHT PF05729.12 EMD70142.1 - 4e-25 88.6 0.1 7.8e-25 87.7 0.1 1.5 1 0 0 1 1 1 1 NACHT domain Nup160 PF11715.8 EMD70142.1 - 3.4e-16 59.0 34.6 0.019 13.6 0.1 10.1 1 1 8 10 10 10 10 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 EMD70142.1 - 1.1e-12 47.7 34.3 0.0022 17.0 2.9 8.3 2 1 7 9 9 9 6 WD40 region of Ge1, enhancer of mRNA-decapping protein HET PF06985.11 EMD70142.1 - 5.8e-11 42.9 10.1 2.4e-10 40.9 0.3 2.9 2 1 1 3 3 3 2 Heterokaryon incompatibility protein (HET) Condensation PF00668.20 EMD70142.1 - 0.11 11.2 0.0 0.27 9.9 0.0 1.6 1 0 0 1 1 1 0 Condensation domain Frtz PF11768.8 EMD70142.1 - 0.12 10.6 10.8 1.9 6.7 0.3 4.1 1 1 4 5 5 5 0 WD repeat-containing and planar cell polarity effector protein Fritz AAA_19 PF13245.6 EMD70142.1 - 0.15 12.4 0.0 0.32 11.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain Stimulus_sens_1 PF13756.6 EMD70142.1 - 0.21 12.2 0.1 18 5.9 0.0 3.0 1 1 1 2 2 2 0 Stimulus-sensing domain WD40_like PF17005.5 EMD70142.1 - 0.35 10.2 8.6 6.6 6.0 0.1 3.7 4 0 0 4 4 4 0 WD40-like domain ADH_N PF08240.12 EMD70143.1 - 9.6e-25 86.6 2.3 1.8e-24 85.7 2.3 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EMD70143.1 - 1.3e-15 57.5 0.0 7.9e-15 55.0 0.0 2.1 2 0 0 2 2 2 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 EMD70143.1 - 8.8e-05 21.9 0.0 0.00015 21.2 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 EMD70143.1 - 0.001 18.4 0.1 0.0017 17.7 0.1 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_2 PF03446.15 EMD70143.1 - 0.084 13.0 0.2 0.19 11.9 0.1 1.7 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase Med12 PF09497.10 EMD70144.1 - 0.045 14.0 0.3 0.12 12.6 0.1 1.9 2 0 0 2 2 2 0 Transcription mediator complex subunit Med12 DUF3970 PF13113.6 EMD70144.1 - 0.11 12.7 1.3 4.4 7.6 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3970) DUF4558 PF15104.6 EMD70144.1 - 1.6 8.9 5.1 6.2 7.0 0.4 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4558) TRP PF06011.12 EMD70145.1 - 3.3e-162 540.1 31.0 3.9e-162 539.8 31.0 1.0 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.6 EMD70145.1 - 7.5e-40 136.5 0.0 1.4e-39 135.6 0.0 1.5 1 0 0 1 1 1 1 ML-like domain Pkinase PF00069.25 EMD70146.1 - 5.2e-12 45.7 0.0 1.9e-11 43.8 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD70146.1 - 2.3e-07 30.4 0.0 1e-06 28.3 0.0 1.9 2 1 0 2 2 2 1 Protein tyrosine kinase His_Phos_1 PF00300.22 EMD70147.1 - 0.0072 16.0 0.9 0.055 13.2 0.9 2.4 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) MBF1 PF08523.10 EMD70148.1 - 8.8e-26 90.2 1.2 8.8e-26 90.2 1.2 1.5 2 0 0 2 2 2 1 Multiprotein bridging factor 1 HTH_3 PF01381.22 EMD70148.1 - 1.4e-07 31.5 0.0 2.5e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix HTH_31 PF13560.6 EMD70148.1 - 0.027 14.8 0.0 0.054 13.8 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain WD40 PF00400.32 EMD70149.1 - 6.7e-22 77.4 6.9 1.9e-05 25.3 0.1 6.5 5 1 1 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EMD70149.1 - 3.3e-10 40.1 0.0 0.0041 17.4 0.0 4.1 3 2 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EMD70149.1 - 0.00034 20.6 0.0 0.68 9.8 0.0 2.7 2 1 1 3 3 3 3 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 EMD70149.1 - 0.0037 16.6 0.0 0.16 11.2 0.0 2.9 3 1 1 4 4 4 1 WD40-like domain MIR PF02815.19 EMD70149.1 - 0.051 13.4 0.1 0.19 11.5 0.1 1.8 1 1 1 2 2 2 0 MIR domain Phage_cap_P2 PF05125.12 EMD70150.1 - 0.25 10.3 0.0 0.38 9.7 0.0 1.2 1 0 0 1 1 1 0 Phage major capsid protein, P2 family FTHFS PF01268.19 EMD70151.1 - 2e-250 831.8 0.3 2.8e-250 831.3 0.3 1.2 1 0 0 1 1 1 1 Formate--tetrahydrofolate ligase THF_DHG_CYH_C PF02882.19 EMD70151.1 - 1.5e-67 225.9 0.8 3.4e-67 224.7 0.8 1.6 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.23 EMD70151.1 - 3e-39 133.9 0.9 6.3e-39 132.9 0.9 1.6 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain OCD_Mu_crystall PF02423.15 EMD70151.1 - 0.0028 16.6 0.1 0.0053 15.7 0.1 1.3 1 0 0 1 1 1 1 Ornithine cyclodeaminase/mu-crystallin family Glyco_trans_1_4 PF13692.6 EMD70151.1 - 0.024 15.1 0.1 0.16 12.4 0.0 2.4 2 0 0 2 2 2 0 Glycosyl transferases group 1 Trehalase PF01204.18 EMD70152.1 - 1.3e-194 647.8 0.0 1.6e-194 647.5 0.0 1.1 1 0 0 1 1 1 1 Trehalase Trehalase_Ca-bi PF07492.11 EMD70152.1 - 4.4e-16 58.3 0.1 7e-16 57.7 0.1 1.3 1 0 0 1 1 1 1 Neutral trehalase Ca2+ binding domain OCRE PF17780.1 EMD70152.1 - 0.024 14.7 0.8 0.17 11.9 0.3 2.6 2 0 0 2 2 2 0 OCRE domain Phosphodiest PF01663.22 EMD70152.1 - 0.053 13.1 0.1 0.12 11.9 0.1 1.5 1 0 0 1 1 1 0 Type I phosphodiesterase / nucleotide pyrophosphatase Lactamase_B PF00753.27 EMD70155.1 - 6.7e-08 32.8 1.9 1.9e-07 31.3 1.9 1.9 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EMD70155.1 - 0.0091 15.5 0.6 0.023 14.2 0.5 1.6 1 1 0 1 1 1 1 Beta-lactamase superfamily domain LisH_TPL PF17814.1 EMD70155.1 - 0.21 11.3 0.5 0.42 10.3 0.5 1.5 1 0 0 1 1 1 0 LisH-like dimerisation domain NAD_binding_2 PF03446.15 EMD70156.1 - 3.8e-29 101.9 0.0 5e-29 101.5 0.0 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 EMD70156.1 - 8.5e-21 74.4 0.0 1.5e-20 73.6 0.0 1.3 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase F420_oxidored PF03807.17 EMD70156.1 - 0.00075 20.0 0.0 0.0014 19.2 0.0 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.20 EMD70156.1 - 0.15 12.2 0.0 0.22 11.6 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase CMD PF02627.20 EMD70157.1 - 4.5e-21 74.7 0.1 1e-20 73.6 0.1 1.5 2 0 0 2 2 2 1 Carboxymuconolactone decarboxylase family TFX_C PF14601.6 EMD70157.1 - 0.1 12.6 0.0 0.2 11.7 0.0 1.4 1 0 0 1 1 1 0 DNA_binding protein, TFX, C-term Fungal_trans PF04082.18 EMD70158.1 - 1e-13 50.9 0.1 2.5e-13 49.7 0.1 1.7 1 0 0 1 1 1 1 Fungal specific transcription factor domain GAF_2 PF13185.6 EMD70158.1 - 0.076 13.3 0.0 0.18 12.1 0.0 1.6 1 0 0 1 1 1 0 GAF domain UQ_con PF00179.26 EMD70159.1 - 7.9e-21 74.2 0.0 1.4e-20 73.4 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.13 EMD70159.1 - 0.1 12.5 0.0 0.22 11.4 0.0 1.6 1 0 0 1 1 1 0 UEV domain FlbD PF06289.11 EMD70159.1 - 0.12 12.0 0.3 19 4.9 0.0 2.5 2 0 0 2 2 2 0 Flagellar and Swarming motility proteins Dor1 PF04124.12 EMD70160.1 - 1.2e-53 182.0 1.4 3.2e-44 151.0 5.1 2.2 1 1 1 2 2 2 2 Dor1-like family Peptidase_C69 PF03577.15 EMD70162.1 - 6.3e-22 78.0 0.0 1.2e-21 77.1 0.0 1.5 1 0 0 1 1 1 1 Peptidase family C69 AAT PF03417.16 EMD70162.1 - 0.096 12.4 0.0 0.15 11.7 0.0 1.2 1 0 0 1 1 1 0 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase CcmH PF03918.14 EMD70162.1 - 0.2 10.9 0.0 0.47 9.7 0.0 1.5 1 0 0 1 1 1 0 Cytochrome C biogenesis protein Peptidase_S58 PF03576.14 EMD70163.1 - 8.2e-113 376.9 0.1 9.8e-113 376.6 0.1 1.0 1 0 0 1 1 1 1 Peptidase family S58 DarA_N PF18788.1 EMD70163.1 - 0.018 15.1 0.0 0.031 14.3 0.0 1.4 1 0 0 1 1 1 0 Defence against restriction A N-terminal Soyouz_module PF14313.6 EMD70163.1 - 0.073 12.9 0.0 0.17 11.7 0.0 1.5 1 0 0 1 1 1 0 N-terminal region of Paramyxovirinae phosphoprotein (P) HMG_box PF00505.19 EMD70164.1 - 1.6e-09 38.1 1.0 4.2e-09 36.7 1.0 1.8 1 0 0 1 1 1 1 HMG (high mobility group) box SAM_2 PF07647.17 EMD70164.1 - 4.7e-06 26.6 0.0 1.2e-05 25.4 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 EMD70164.1 - 2.6e-05 24.6 0.0 6.6e-05 23.3 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) HMG_box_2 PF09011.10 EMD70164.1 - 0.017 15.7 1.6 0.041 14.5 1.6 1.7 1 0 0 1 1 1 0 HMG-box domain Coiled-coil_56 PF09813.9 EMD70165.1 - 0.057 13.5 0.2 0.12 12.5 0.2 1.4 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 56 adh_short_C2 PF13561.6 EMD70166.1 - 2.5e-49 167.9 0.5 3e-49 167.7 0.5 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EMD70166.1 - 1.1e-46 158.8 0.2 1.3e-46 158.5 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EMD70166.1 - 6.4e-07 29.5 0.1 1.4e-06 28.3 0.0 1.6 2 0 0 2 2 2 1 KR domain THF_DHG_CYH_C PF02882.19 EMD70166.1 - 0.00058 19.2 0.1 0.0011 18.4 0.1 1.5 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain DUF1776 PF08643.10 EMD70166.1 - 0.052 12.9 0.0 2.8 7.2 0.0 2.1 2 0 0 2 2 2 0 Fungal family of unknown function (DUF1776) Epimerase PF01370.21 EMD70166.1 - 0.083 12.3 0.0 0.12 11.9 0.0 1.5 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family BCAS2 PF05700.11 EMD70167.1 - 8.1e-47 159.6 1.4 9.9e-47 159.3 1.4 1.0 1 0 0 1 1 1 1 Breast carcinoma amplified sequence 2 (BCAS2) FlxA PF14282.6 EMD70167.1 - 0.074 13.0 3.4 0.17 11.9 3.4 1.6 1 0 0 1 1 1 0 FlxA-like protein FlaC_arch PF05377.11 EMD70167.1 - 0.94 9.9 3.0 3.9 7.9 0.8 2.3 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) Ceramidase_alk PF04734.13 EMD70168.1 - 1.9e-224 746.0 0.0 2.2e-224 745.8 0.0 1.0 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, N-terminal Ceramidse_alk_C PF17048.5 EMD70168.1 - 4.6e-60 202.3 0.0 7.6e-60 201.6 0.0 1.4 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, C-terminal TMEM190 PF15431.6 EMD70169.1 - 0.11 12.6 0.0 0.27 11.4 0.0 1.6 2 0 0 2 2 2 0 Transmembrane protein 190 RSN1_7TM PF02714.15 EMD70170.1 - 4e-93 311.7 18.1 9.2e-93 310.5 18.1 1.6 1 0 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 EMD70170.1 - 2.9e-41 140.9 0.2 2.9e-41 140.9 0.2 2.6 4 0 0 4 4 4 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 EMD70170.1 - 3.3e-32 112.1 0.3 6.1e-32 111.3 0.3 1.5 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter PHM7_ext PF12621.8 EMD70170.1 - 4e-22 78.2 0.0 8.6e-22 77.1 0.0 1.5 1 0 0 1 1 1 1 Extracellular tail, of 10TM putative phosphate transporter DUF2839 PF10999.8 EMD70170.1 - 2.7 8.4 5.7 0.74 10.2 0.3 3.0 4 0 0 4 4 4 0 Protein of unknown function (DUF2839) Glyco_hydro_61 PF03443.14 EMD70171.1 - 7.6e-53 179.5 0.2 1e-52 179.1 0.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 CAF-1_p60_C PF15512.6 EMD70171.1 - 0.096 13.2 10.0 0.17 12.3 10.0 1.4 1 0 0 1 1 1 0 Chromatin assembly factor complex 1 subunit p60, C-terminal DUF908 PF06012.12 EMD70171.1 - 0.31 10.4 0.6 0.49 9.7 0.6 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) MSA-2c PF12238.8 EMD70171.1 - 0.36 10.8 10.6 0.61 10.1 10.6 1.3 1 0 0 1 1 1 0 Merozoite surface antigen 2c Asp PF00026.23 EMD70173.1 - 6.7e-11 42.2 0.1 1e-10 41.6 0.1 1.2 1 0 0 1 1 1 1 Eukaryotic aspartyl protease RskA PF10099.9 EMD70173.1 - 2.1 8.6 7.3 0.39 11.0 1.3 2.4 2 1 0 2 2 2 0 Anti-sigma-K factor rskA Pkinase PF00069.25 EMD70174.1 - 4.6e-61 206.5 0.0 1.4e-60 204.9 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain DEAD PF00270.29 EMD70174.1 - 2.3e-46 157.7 0.0 5.9e-46 156.4 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Pkinase_Tyr PF07714.17 EMD70174.1 - 5.5e-26 91.4 0.0 8.5e-25 87.5 0.1 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase Helicase_C PF00271.31 EMD70174.1 - 1.5e-24 86.4 0.0 1e-23 83.8 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EMD70174.1 - 1.7e-19 69.8 0.3 3.8e-19 68.7 0.3 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 EMD70174.1 - 6.8e-05 22.9 0.0 0.00021 21.3 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EMD70174.1 - 0.0022 17.3 0.0 0.005 16.1 0.0 1.5 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Haspin_kinase PF12330.8 EMD70174.1 - 0.019 13.9 0.3 0.18 10.7 0.0 2.4 2 1 1 3 3 3 0 Haspin like kinase domain APH PF01636.23 EMD70174.1 - 0.13 12.2 0.1 0.5 10.2 0.1 1.8 1 1 0 1 1 1 0 Phosphotransferase enzyme family SWI-SNF_Ssr4 PF08549.10 EMD70174.1 - 0.25 9.9 7.6 0.37 9.4 7.6 1.2 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) Pox_Ag35 PF03286.14 EMD70174.1 - 1.2 8.9 12.3 2.1 8.1 12.3 1.4 1 0 0 1 1 1 0 Pox virus Ag35 surface protein NPR3 PF03666.13 EMD70174.1 - 1.8 7.2 6.2 2.7 6.7 6.2 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 HemY_N PF07219.13 EMD70174.1 - 2.3 8.5 4.3 5.3 7.3 4.3 1.5 1 0 0 1 1 1 0 HemY protein N-terminus zf-C2H2_4 PF13894.6 EMD70177.1 - 3e-05 24.5 4.8 0.011 16.5 1.5 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 EMD70177.1 - 0.00053 20.3 2.1 0.00053 20.3 2.1 3.3 3 1 0 3 3 3 1 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EMD70177.1 - 0.00091 19.6 4.1 0.014 15.8 1.1 2.7 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2_2 PF12756.7 EMD70177.1 - 0.0035 17.6 0.6 0.0069 16.7 0.6 1.5 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) zf-C2H2_6 PF13912.6 EMD70177.1 - 0.0036 17.3 4.2 0.0042 17.0 0.7 2.5 2 0 0 2 2 2 1 C2H2-type zinc finger zf-BED PF02892.15 EMD70177.1 - 0.005 16.8 6.0 0.6 10.2 2.1 2.6 2 0 0 2 2 2 2 BED zinc finger zf-C2H2_11 PF16622.5 EMD70177.1 - 0.0084 15.9 4.1 1.5 8.7 0.1 2.9 2 0 0 2 2 2 2 zinc-finger C2H2-type zf-C2H2_3 PF13878.6 EMD70177.1 - 0.022 14.6 0.4 0.89 9.4 0.1 2.4 2 0 0 2 2 2 0 zinc-finger of acetyl-transferase ESCO Cytochrom_c3_2 PF14537.6 EMD70177.1 - 0.067 13.7 0.8 0.17 12.3 0.8 1.7 1 0 0 1 1 1 0 Cytochrome c3 zf-met PF12874.7 EMD70177.1 - 0.1 13.1 0.8 0.3 11.5 0.3 2.2 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zinc_ribbon_5 PF13719.6 EMD70177.1 - 0.2 11.4 0.7 1.1 9.1 0.0 2.1 2 0 0 2 2 2 0 zinc-ribbon domain zf-H2C2_5 PF13909.6 EMD70177.1 - 8.4 6.3 14.7 1.7 8.5 1.2 3.0 3 0 0 3 3 3 0 C2H2-type zinc-finger domain Actin PF00022.19 EMD70178.1 - 1e-28 100.1 0.0 5e-28 97.8 0.0 2.0 2 1 0 2 2 2 1 Actin MreB_Mbl PF06723.13 EMD70178.1 - 0.00075 18.4 0.0 0.36 9.6 0.0 2.1 2 0 0 2 2 2 2 MreB/Mbl protein PilM_2 PF11104.8 EMD70178.1 - 0.0024 16.9 0.0 0.46 9.5 0.0 2.1 2 0 0 2 2 2 2 Type IV pilus assembly protein PilM; Nop PF01798.18 EMD70179.1 - 4.4e-79 265.2 0.2 4.4e-79 265.2 0.2 1.7 2 0 0 2 2 2 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 EMD70179.1 - 1.7e-15 57.1 1.2 1.7e-15 57.1 1.2 2.4 2 0 0 2 2 2 1 NOP5NT (NUC127) domain DUF760 PF05542.11 EMD70179.1 - 0.055 13.8 0.2 0.3 11.5 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF760) DUF1205 PF06722.12 EMD70179.1 - 0.14 12.3 0.0 4.1 7.6 0.0 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1205) NAM-associated PF14303.6 EMD70179.1 - 1.4 9.6 28.3 3.8 8.2 27.7 2.0 2 0 0 2 2 2 0 No apical meristem-associated C-terminal domain RNA_pol_Rpb4 PF03874.16 EMD70180.1 - 1.8e-19 70.3 0.0 2.6e-19 69.8 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb4 zf-MYND PF01753.18 EMD70182.1 - 1.5e-08 34.6 17.7 2.7e-08 33.8 17.7 1.4 1 0 0 1 1 1 1 MYND finger zf-C6H2 PF15801.5 EMD70182.1 - 0.029 14.7 14.4 0.055 13.8 14.4 1.4 1 0 0 1 1 1 0 zf-MYND-like zinc finger, mRNA-binding Rhodanese_C PF12368.8 EMD70182.1 - 0.045 14.1 10.0 0.062 13.7 10.0 1.2 1 0 0 1 1 1 0 Rhodanase C-terminal ROS_MUCR PF05443.11 EMD70182.1 - 0.05 13.7 0.7 0.072 13.1 0.7 1.2 1 0 0 1 1 1 0 ROS/MUCR transcriptional regulator protein PolC_DP2 PF03833.13 EMD70182.1 - 0.051 11.4 6.3 0.055 11.3 6.3 1.0 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 zf-C2H2 PF00096.26 EMD70182.1 - 2.2 8.9 6.5 9.1 7.0 2.6 2.4 2 0 0 2 2 2 0 Zinc finger, C2H2 type GrpB PF04229.14 EMD70184.1 - 1.3e-42 145.7 0.1 2.1e-42 145.0 0.1 1.4 1 0 0 1 1 1 1 GrpB protein Acetyltransf_3 PF13302.7 EMD70184.1 - 4.6e-21 75.9 0.0 7.1e-21 75.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EMD70184.1 - 1.5e-05 25.2 0.0 2.5e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family GNAT_acetyltran PF12746.7 EMD70184.1 - 0.0018 17.9 0.0 0.0043 16.6 0.0 1.5 1 0 0 1 1 1 1 GNAT acetyltransferase Acetyltransf_8 PF13523.6 EMD70184.1 - 0.015 15.0 0.0 0.028 14.1 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain FR47 PF08445.10 EMD70184.1 - 0.055 13.4 0.0 0.13 12.3 0.0 1.5 1 0 0 1 1 1 0 FR47-like protein Acetyltransf_7 PF13508.7 EMD70184.1 - 0.088 13.3 0.0 0.19 12.2 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain EAF PF09816.9 EMD70186.1 - 1.8e-17 63.6 1.3 1.8e-17 63.6 1.3 1.8 2 0 0 2 2 2 1 RNA polymerase II transcription elongation factor Bys1 PF04681.12 EMD70187.1 - 2.3e-07 30.9 0.1 2.5e-07 30.8 0.1 1.2 1 0 0 1 1 1 1 Blastomyces yeast-phase-specific protein DUF5024 PF16427.5 EMD70187.1 - 0.029 14.7 0.0 0.04 14.2 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5024) Pkinase PF00069.25 EMD70188.1 - 4.3e-16 59.1 0.0 4.5e-08 32.8 0.0 2.8 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EMD70188.1 - 3.8e-09 36.2 0.0 4.7e-06 26.1 0.0 2.4 2 1 0 2 2 2 2 Protein tyrosine kinase Glyco_hydro_2_N PF02837.18 EMD70189.1 - 5.3e-14 52.5 1.1 4.1e-13 49.6 0.5 2.7 1 1 1 2 2 2 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2_C PF02836.17 EMD70189.1 - 1.1e-11 44.4 0.0 3.1e-11 42.9 0.0 1.7 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_2 PF00703.21 EMD70189.1 - 6.6e-10 39.6 0.1 2.6e-09 37.7 0.2 1.9 2 0 0 2 2 2 1 Glycosyl hydrolases family 2 Acetyltransf_3 PF13302.7 EMD70190.1 - 2.7e-13 50.8 0.0 3.5e-13 50.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EMD70190.1 - 5.3e-13 49.2 0.1 6.9e-13 48.9 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EMD70190.1 - 6.3e-08 32.9 0.1 8.7e-08 32.5 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 EMD70190.1 - 0.00035 20.7 0.0 0.00048 20.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EMD70190.1 - 0.00036 20.5 0.0 0.0005 20.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EMD70190.1 - 0.0016 18.4 0.0 0.0026 17.7 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Ribosomal_S15 PF00312.22 EMD70191.1 - 1.8e-25 88.9 1.2 7.6e-25 86.9 0.1 2.5 3 0 0 3 3 3 1 Ribosomal protein S15 SPATA25 PF15218.6 EMD70191.1 - 0.007 16.2 0.2 0.015 15.1 0.0 1.7 2 0 0 2 2 2 1 Spermatogenesis-associated protein 25 Mito_fiss_reg PF05308.11 EMD70191.1 - 0.041 14.0 0.5 0.041 14.0 0.5 1.8 1 1 0 1 1 1 0 Mitochondrial fission regulator Ribosomal_S2 PF00318.20 EMD70192.1 - 9.3e-24 83.9 0.0 1e-13 51.0 0.0 2.1 1 1 1 2 2 2 2 Ribosomal protein S2 40S_SA_C PF16122.5 EMD70192.1 - 6.8e-09 37.0 14.1 1.3e-08 36.1 14.1 1.5 1 0 0 1 1 1 1 40S ribosomal protein SA C-terminus Glyco_hydro_72 PF03198.14 EMD70193.1 - 5.1e-99 331.5 0.6 6.6e-99 331.1 0.6 1.0 1 0 0 1 1 1 1 Glucanosyltransferase Cellulase PF00150.18 EMD70193.1 - 0.0012 18.3 1.3 0.025 14.0 1.2 2.1 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_2_C PF02836.17 EMD70193.1 - 0.059 12.5 0.4 0.17 11.0 0.4 1.8 1 1 0 1 1 1 0 Glycosyl hydrolases family 2, TIM barrel domain Sec23_BS PF08033.12 EMD70194.1 - 0.15 12.8 0.1 1.2 10.0 0.0 2.3 2 0 0 2 2 2 0 Sec23/Sec24 beta-sandwich domain PhnJ PF06007.11 EMD70195.1 - 0.12 11.4 0.0 0.18 10.8 0.0 1.2 1 0 0 1 1 1 0 Phosphonate metabolism protein PhnJ HATPase_c PF02518.26 EMD70196.1 - 6.1e-23 81.5 0.1 1.3e-22 80.4 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EMD70196.1 - 1.6e-17 63.7 0.0 1.8e-12 47.4 0.0 2.5 2 0 0 2 2 2 2 Response regulator receiver domain HisKA PF00512.25 EMD70196.1 - 4.5e-11 42.6 0.1 2.1e-10 40.5 0.0 2.3 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain PAS_4 PF08448.10 EMD70196.1 - 1.5e-06 28.4 0.7 0.0015 18.8 0.0 4.0 4 0 0 4 4 4 1 PAS fold PAS_8 PF13188.7 EMD70196.1 - 0.0087 16.1 0.0 0.14 12.2 0.0 2.9 2 0 0 2 2 2 1 PAS domain PAS PF00989.25 EMD70196.1 - 0.053 13.5 0.0 0.53 10.3 0.0 2.8 3 1 0 3 3 3 0 PAS fold Snapin_Pallidin PF14712.6 EMD70196.1 - 0.16 12.4 0.9 0.4 11.1 0.3 1.9 2 0 0 2 2 2 0 Snapin/Pallidin Peroxidase_2 PF01328.17 EMD70197.1 - 4.2e-48 164.4 0.0 6e-48 163.9 0.0 1.2 1 0 0 1 1 1 1 Peroxidase, family 2 Fungal_trans PF04082.18 EMD70198.1 - 1.1e-13 50.8 1.3 1.1e-13 50.8 1.3 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 EMD70198.1 - 1.6e-09 37.7 11.6 4.7e-05 23.6 5.4 3.7 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 EMD70198.1 - 0.00044 20.2 5.1 0.00079 19.4 2.1 2.7 2 0 0 2 2 2 1 C2H2-type zinc finger zf-H2C2_2 PF13465.6 EMD70198.1 - 0.00056 20.2 5.2 0.053 14.0 0.6 3.1 2 0 0 2 2 2 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 EMD70198.1 - 0.005 17.6 3.4 0.005 17.6 3.4 3.7 4 0 0 4 4 4 2 C2H2-type zinc finger Aldedh PF00171.22 EMD70199.1 - 3.7e-78 263.1 0.0 4.5e-78 262.8 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family GFO_IDH_MocA PF01408.22 EMD70200.1 - 4.5e-14 53.3 0.0 6.9e-14 52.7 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold NAD_binding_3 PF03447.16 EMD70200.1 - 0.00014 22.5 0.1 0.00024 21.7 0.1 1.4 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain Abhydrolase_4 PF08386.10 EMD70201.1 - 2.9e-14 53.0 0.0 6.8e-14 51.8 0.0 1.6 1 0 0 1 1 1 1 TAP-like protein Abhydrolase_1 PF00561.20 EMD70201.1 - 3.2e-13 49.9 0.0 7.2e-12 45.5 0.0 2.1 2 0 0 2 2 2 1 alpha/beta hydrolase fold Thioredoxin PF00085.20 EMD70202.1 - 4.3e-28 97.3 0.1 5.6e-28 96.9 0.1 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 EMD70202.1 - 1.4e-09 38.1 0.1 4.8e-06 26.8 0.0 2.2 1 1 1 2 2 2 2 Thioredoxin-like Thioredoxin_2 PF13098.6 EMD70202.1 - 6.7e-08 32.9 0.2 3.5e-07 30.6 0.2 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain AhpC-TSA PF00578.21 EMD70202.1 - 1.2e-06 28.5 0.2 0.0041 17.0 0.1 2.2 1 1 1 2 2 2 2 AhpC/TSA family OST3_OST6 PF04756.13 EMD70202.1 - 2.6e-06 27.0 0.0 3.2e-06 26.7 0.0 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_9 PF14595.6 EMD70202.1 - 4.6e-05 23.2 0.0 6.4e-05 22.7 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Redoxin PF08534.10 EMD70202.1 - 6.5e-05 22.7 0.2 0.22 11.3 0.0 2.2 1 1 1 2 2 2 2 Redoxin Thioredoxin_7 PF13899.6 EMD70202.1 - 0.00014 21.9 0.0 0.00024 21.2 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like TraF PF13728.6 EMD70202.1 - 0.0017 18.2 0.1 0.0025 17.7 0.1 1.2 1 0 0 1 1 1 1 F plasmid transfer operon protein HyaE PF07449.11 EMD70202.1 - 0.049 13.6 0.0 0.084 12.8 0.0 1.3 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE zf-PARP PF00645.18 EMD70203.1 - 2.3e-26 92.5 7.8 1.3e-16 61.2 0.6 3.3 3 0 0 3 3 3 2 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region CALCOCO1 PF07888.11 EMD70204.1 - 0.00083 18.3 10.2 0.00083 18.3 10.2 1.4 2 0 0 2 2 2 1 Calcium binding and coiled-coil domain (CALCOCO1) like TMF_TATA_bd PF12325.8 EMD70204.1 - 0.01 16.1 13.9 0.39 11.0 0.6 2.4 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding Golgin_A5 PF09787.9 EMD70204.1 - 0.016 14.7 10.2 0.022 14.2 10.2 1.3 1 0 0 1 1 1 0 Golgin subfamily A member 5 DUF5082 PF16888.5 EMD70204.1 - 0.028 14.7 17.8 0.43 10.9 0.2 3.1 1 1 2 3 3 3 0 Domain of unknown function (DUF5082) KASH_CCD PF14662.6 EMD70204.1 - 0.034 14.0 17.9 0.25 11.2 17.8 2.0 1 1 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH Spc29 PF17082.5 EMD70204.1 - 0.086 12.7 9.1 1.3 8.8 9.1 2.1 1 1 0 1 1 1 0 Spindle Pole Component 29 Tropomyosin PF00261.20 EMD70204.1 - 0.087 12.2 13.8 0.026 13.9 9.4 1.8 2 0 0 2 2 2 0 Tropomyosin DUF2205 PF10224.9 EMD70204.1 - 0.15 12.0 11.1 0.87 9.6 7.4 3.1 2 1 1 3 3 3 0 Short coiled-coil protein DUF4472 PF14739.6 EMD70204.1 - 0.17 12.7 14.4 0.049 14.4 8.6 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4472) DUF4407 PF14362.6 EMD70204.1 - 0.19 11.1 6.6 0.26 10.6 6.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DivIC PF04977.15 EMD70204.1 - 0.19 11.5 17.3 0.62 9.9 4.0 2.9 1 1 2 3 3 3 0 Septum formation initiator V_ATPase_I PF01496.19 EMD70204.1 - 0.19 9.6 4.9 0.2 9.6 4.9 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Cnn_1N PF07989.11 EMD70204.1 - 0.37 11.0 12.1 0.21 11.8 1.0 2.8 2 2 0 2 2 2 0 Centrosomin N-terminal motif 1 ADIP PF11559.8 EMD70204.1 - 0.48 10.5 23.3 0.68 10.0 11.9 2.5 2 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding Cortex-I_coil PF09304.10 EMD70204.1 - 0.73 10.1 7.7 0.7 10.1 6.1 1.8 1 1 1 2 2 2 0 Cortexillin I, coiled coil DUF1664 PF07889.12 EMD70204.1 - 0.76 9.8 8.5 1.8 8.6 5.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) SIKE PF05769.11 EMD70204.1 - 1.6 8.6 16.6 5.1 7.0 6.5 2.6 1 1 1 2 2 2 0 SIKE family DUF724 PF05266.14 EMD70204.1 - 2 8.2 12.4 0.38 10.6 8.4 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF724) HALZ PF02183.18 EMD70204.1 - 2 8.7 11.6 1.3 9.3 0.2 3.4 4 0 0 4 4 4 0 Homeobox associated leucine zipper YlqD PF11068.8 EMD70204.1 - 2.6 8.4 16.6 0.34 11.3 12.4 1.6 2 0 0 2 2 2 0 YlqD protein TMCO5 PF14992.6 EMD70204.1 - 3 7.4 15.0 5.3 6.5 14.9 1.5 1 1 0 1 1 1 0 TMCO5 family BRE1 PF08647.11 EMD70204.1 - 3.2 7.9 16.6 0.18 11.9 8.2 2.6 2 1 1 3 3 3 0 BRE1 E3 ubiquitin ligase DUF2312 PF10073.9 EMD70204.1 - 5.6 6.7 10.3 1.9 8.2 1.1 2.7 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2312) Spc24 PF08286.11 EMD70204.1 - 7.4 6.9 16.0 2 8.7 4.6 2.6 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 FYVE PF01363.21 EMD70205.1 - 0.0031 17.6 4.5 0.0031 17.6 4.5 2.8 3 1 1 4 4 4 1 FYVE zinc finger Amidohydro_1 PF01979.20 EMD70206.1 - 1.7e-13 50.6 2.5 2.8e-12 46.6 2.5 2.5 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EMD70206.1 - 9.9e-12 45.1 1.7 4.4e-08 33.0 0.1 2.4 1 1 0 2 2 2 2 Amidohydrolase family Pkinase PF00069.25 EMD70207.1 - 1.2e-46 159.3 0.0 1.6e-46 158.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD70207.1 - 1.7e-25 89.8 0.0 2.3e-25 89.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EMD70207.1 - 0.00015 21.8 0.1 0.011 15.6 0.0 2.7 2 1 1 3 3 3 1 Phosphotransferase enzyme family Kdo PF06293.14 EMD70207.1 - 0.0012 18.3 0.0 0.0024 17.3 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 EMD70207.1 - 0.0047 16.5 1.1 0.015 14.9 0.0 2.2 3 0 0 3 3 3 1 RIO1 family Choline_kinase PF01633.20 EMD70207.1 - 0.018 14.6 0.0 0.051 13.2 0.0 1.8 1 1 0 1 1 1 0 Choline/ethanolamine kinase Haspin_kinase PF12330.8 EMD70207.1 - 0.085 11.8 0.0 0.21 10.5 0.0 1.5 1 1 0 1 1 1 0 Haspin like kinase domain Sugar_tr PF00083.24 EMD70208.1 - 7.6e-76 255.8 21.1 8.7e-76 255.6 21.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EMD70208.1 - 2.1e-18 66.4 36.1 1.3e-10 40.7 21.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily tRNA-synt_1b PF00579.25 EMD70209.1 - 2.5e-20 73.0 0.0 4.3e-20 72.2 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) PRELI PF04707.14 EMD70210.1 - 6.9e-22 77.9 0.0 5.2e-19 68.6 0.0 2.3 2 0 0 2 2 2 2 PRELI-like family BTB PF00651.31 EMD70211.1 - 3.1e-07 30.6 2.0 4.7e-06 26.8 0.1 2.7 3 0 0 3 3 3 1 BTB/POZ domain PIN_2 PF10130.9 EMD70211.1 - 0.066 13.4 1.6 0.46 10.7 0.0 2.6 3 0 0 3 3 3 0 PIN domain COMMD1_N PF17221.3 EMD70211.1 - 0.067 13.5 1.5 5.8 7.3 0.0 3.2 3 0 0 3 3 3 0 COMMD1 N-terminal domain GCP_C_terminal PF04130.13 EMD70212.1 - 7.3e-97 324.6 0.3 1.8e-96 323.3 0.1 1.8 2 0 0 2 2 2 1 Gamma tubulin complex component C-terminal GCP_N_terminal PF17681.1 EMD70212.1 - 2.4e-80 270.5 0.0 9.8e-80 268.4 0.0 1.9 2 0 0 2 2 2 1 Gamma tubulin complex component N-terminal V-set_CD47 PF08204.11 EMD70212.1 - 0.018 15.0 0.0 0.038 14.0 0.0 1.4 1 0 0 1 1 1 0 CD47 immunoglobulin-like domain TPR_20 PF14561.6 EMD70212.1 - 4.5 7.7 6.2 0.78 10.1 0.1 3.0 4 0 0 4 4 4 0 Tetratricopeptide repeat PhyH PF05721.13 EMD70213.1 - 1.1e-08 35.6 0.1 3.9e-08 33.8 0.1 1.9 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) DUF1479 PF07350.12 EMD70213.1 - 0.00026 19.9 0.3 2.9 6.5 0.0 3.0 3 0 0 3 3 3 3 Protein of unknown function (DUF1479) 2OG-FeII_Oxy_5 PF13759.6 EMD70213.1 - 0.11 12.9 0.0 0.31 11.5 0.0 1.8 1 0 0 1 1 1 0 Putative 2OG-Fe(II) oxygenase FAD_binding_3 PF01494.19 EMD70214.1 - 1.7e-18 67.0 0.0 4e-18 65.8 0.0 1.5 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.24 EMD70214.1 - 2.2e-05 24.2 0.1 0.00014 21.6 0.1 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EMD70214.1 - 7.7e-05 22.9 0.1 0.00021 21.4 0.1 1.9 1 1 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EMD70214.1 - 0.00021 20.5 0.2 0.00042 19.5 0.1 1.5 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.14 EMD70214.1 - 0.0003 20.1 0.1 0.00096 18.5 0.1 1.8 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 EMD70214.1 - 0.0055 16.0 0.4 0.47 9.7 0.0 2.5 3 0 0 3 3 3 1 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox_3 PF13738.6 EMD70214.1 - 0.0058 15.9 0.1 0.0094 15.2 0.1 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EMD70214.1 - 0.0068 15.3 0.1 0.98 8.2 0.1 2.8 3 0 0 3 3 3 1 Tryptophan halogenase HI0933_like PF03486.14 EMD70214.1 - 0.06 12.0 0.0 0.069 11.8 0.0 1.3 1 0 0 1 1 1 0 HI0933-like protein Pyr_redox PF00070.27 EMD70214.1 - 0.17 12.5 0.1 0.37 11.4 0.1 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EMD70214.1 - 0.95 8.4 2.7 4.3 6.3 0.6 2.6 2 1 0 2 2 2 0 Lycopene cyclase protein MFS_1 PF07690.16 EMD70215.1 - 2e-26 92.8 22.3 2e-26 92.8 22.3 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EMD70215.1 - 3.7e-07 29.4 9.2 3.7e-07 29.4 9.2 3.0 2 1 0 3 3 3 1 Sugar (and other) transporter TRI12 PF06609.13 EMD70215.1 - 1.6e-05 23.6 2.6 1.6e-05 23.6 2.6 1.6 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Chitin_synth_1 PF01644.17 EMD70216.1 - 7e-75 250.5 0.6 1.1e-74 249.8 0.6 1.3 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.11 EMD70216.1 - 9.2e-30 102.4 0.0 1.9e-29 101.4 0.0 1.6 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.15 EMD70216.1 - 1.4e-20 73.4 9.1 2.7e-18 65.9 0.1 2.6 3 0 0 3 3 3 2 Chitin synthase Glyco_trans_2_3 PF13632.6 EMD70216.1 - 5e-07 29.8 15.2 7.7e-06 26.0 15.2 2.7 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 EMD70216.1 - 0.0028 17.6 0.0 0.0057 16.6 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase like family 2 LMWPc PF01451.21 EMD70217.1 - 5.8e-29 101.3 0.0 7.6e-29 100.9 0.0 1.2 1 0 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase MFS_1 PF07690.16 EMD70220.1 - 3.4e-09 36.1 8.7 3.4e-09 36.1 8.7 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EMD70220.1 - 0.00017 20.6 4.7 0.00017 20.6 4.7 2.0 3 0 0 3 3 3 1 Sugar (and other) transporter PSI_PSAK PF01241.18 EMD70220.1 - 0.007 16.3 1.3 0.16 12.0 0.1 2.6 2 0 0 2 2 2 1 Photosystem I psaG / psaK AAA PF00004.29 EMD70221.1 - 1.3e-19 70.9 0.0 2.3e-17 63.7 0.0 3.1 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EMD70221.1 - 0.00043 20.3 0.0 0.0011 19.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EMD70221.1 - 0.0023 18.4 0.0 0.0067 16.8 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EMD70221.1 - 0.0055 17.0 0.1 0.029 14.7 0.1 2.1 1 1 0 1 1 1 1 AAA domain Hydin_ADK PF17213.3 EMD70221.1 - 0.82 9.9 3.3 5.1 7.3 0.0 2.8 3 0 0 3 3 3 0 Hydin Adenylate kinase-like domain zinc_ribbon_2 PF13240.6 EMD70221.1 - 1.2 9.0 4.7 2.6 7.9 4.7 1.6 1 0 0 1 1 1 0 zinc-ribbon domain BRD4_CDT PF17105.5 EMD70221.1 - 1.4 8.5 4.3 0.9 9.2 1.6 2.0 2 0 0 2 2 2 0 C-terminal domain of bromodomain protein 4 COMPASS-Shg1 PF05205.12 EMD70222.1 - 0.54 11.0 3.6 3.1 8.6 1.7 2.4 2 0 0 2 2 2 0 COMPASS (Complex proteins associated with Set1p) component shg1 MFS_1 PF07690.16 EMD70223.1 - 5.6e-30 104.4 30.5 5.6e-30 104.4 30.5 1.9 2 0 0 2 2 2 1 Major Facilitator Superfamily UNC-93 PF05978.16 EMD70223.1 - 0.0053 16.5 3.4 0.0097 15.6 3.4 1.5 1 0 0 1 1 1 1 Ion channel regulatory protein UNC-93 Pkinase PF00069.25 EMD70224.1 - 2.2e-75 253.4 0.0 3e-75 253.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EMD70224.1 - 2.6e-39 135.1 0.0 3.6e-39 134.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase AdenylateSensor PF16579.5 EMD70224.1 - 1.4e-17 64.2 0.0 7.1e-08 32.9 0.0 3.5 3 0 0 3 3 3 3 Adenylate sensor of SNF1-like protein kinase UBA_2 PF08587.11 EMD70224.1 - 5.4e-17 61.6 0.1 1.1e-16 60.6 0.1 1.6 1 0 0 1 1 1 1 Ubiquitin associated domain (UBA) Kinase-like PF14531.6 EMD70224.1 - 3.9e-06 26.4 0.0 9.1e-06 25.2 0.0 1.6 1 1 1 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 EMD70224.1 - 0.0036 16.3 0.2 0.0062 15.5 0.2 1.4 1 0 0 1 1 1 1 Haspin like kinase domain RIO1 PF01163.22 EMD70224.1 - 0.004 16.8 0.1 0.0093 15.6 0.1 1.6 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.14 EMD70224.1 - 0.015 14.7 1.0 0.018 14.4 0.1 1.5 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EMD70224.1 - 0.032 14.2 0.6 0.18 11.7 0.3 2.3 1 1 1 2 2 2 0 Phosphotransferase enzyme family YukC PF10140.9 EMD70224.1 - 0.17 10.7 0.1 0.25 10.1 0.1 1.2 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukC TPR_1 PF00515.28 EMD70225.1 - 2.6e-34 115.6 29.0 0.00039 20.1 0.0 11.4 11 0 0 11 11 11 9 Tetratricopeptide repeat TPR_2 PF07719.17 EMD70225.1 - 3.5e-34 114.1 25.7 0.00024 21.0 0.0 11.3 11 0 0 11 11 11 8 Tetratricopeptide repeat TPR_16 PF13432.6 EMD70225.1 - 7.6e-21 74.5 10.2 5.5e-05 23.7 0.8 6.9 6 1 1 7 7 7 5 Tetratricopeptide repeat TPR_8 PF13181.6 EMD70225.1 - 1e-18 65.9 21.4 0.023 14.9 0.1 10.2 10 0 0 10 10 10 6 Tetratricopeptide repeat TPR_11 PF13414.6 EMD70225.1 - 1e-16 60.3 25.4 0.00017 21.2 0.0 8.7 8 1 1 9 9 9 6 TPR repeat TPR_17 PF13431.6 EMD70225.1 - 1.3e-15 56.6 13.8 0.0021 18.3 0.0 9.2 10 0 0 10 10 8 3 Tetratricopeptide repeat TPR_12 PF13424.6 EMD70225.1 - 3.5e-12 46.4 30.8 0.00022 21.5 1.4 8.9 3 2 5 8 8 8 5 Tetratricopeptide repeat TPR_9 PF13371.6 EMD70225.1 - 9e-10 38.6 10.3 0.00015 21.8 0.2 5.0 5 1 0 6 6 6 2 Tetratricopeptide repeat TPR_19 PF14559.6 EMD70225.1 - 3e-09 37.3 25.1 6.6e-06 26.5 0.3 6.9 5 1 0 7 7 7 3 Tetratricopeptide repeat TPR_14 PF13428.6 EMD70225.1 - 7.4e-09 35.7 20.4 0.032 15.0 0.3 7.6 6 3 3 9 9 7 3 Tetratricopeptide repeat TPR_7 PF13176.6 EMD70225.1 - 8.3e-09 34.9 17.4 0.05 13.6 0.1 8.9 9 0 0 9 9 9 3 Tetratricopeptide repeat ANAPC3 PF12895.7 EMD70225.1 - 1.9e-07 31.2 12.3 0.009 16.2 0.1 5.0 3 2 2 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.6 EMD70225.1 - 1e-06 28.4 22.0 0.029 14.2 0.2 8.3 9 0 0 9 9 9 2 Tetratricopeptide repeat TPR_MalT PF17874.1 EMD70225.1 - 5.8e-06 25.9 1.7 1.1e-05 25.0 0.3 2.0 1 1 0 1 1 1 1 MalT-like TPR region SHNi-TPR PF10516.9 EMD70225.1 - 7.7e-06 25.3 4.7 0.75 9.3 0.0 5.5 5 0 0 5 5 5 2 SHNi-TPR DUF3856 PF12968.7 EMD70225.1 - 0.0023 18.0 5.5 4.8 7.2 0.0 5.4 4 2 0 5 5 5 1 Domain of Unknown Function (DUF3856) MAS20 PF02064.15 EMD70225.1 - 0.0066 16.5 10.3 0.13 12.3 0.6 4.5 4 1 1 5 5 5 1 MAS20 protein import receptor SPO22 PF08631.10 EMD70225.1 - 0.014 14.9 1.7 5.1 6.5 0.0 3.8 4 0 0 4 4 4 0 Meiosis protein SPO22/ZIP4 like RFX5_DNA_bdg PF14621.6 EMD70225.1 - 0.015 15.1 5.0 0.026 14.3 5.0 1.4 1 0 0 1 1 1 0 RFX5 DNA-binding domain TPR_6 PF13174.6 EMD70225.1 - 0.032 14.9 15.8 13 6.7 0.5 7.8 8 0 0 8 8 7 0 Tetratricopeptide repeat TAF1_subA PF14929.6 EMD70225.1 - 0.034 13.6 1.1 0.17 11.3 0.1 2.2 2 1 0 2 2 2 0 TAF RNA Polymerase I subunit A HrpB1_HrpK PF09613.10 EMD70225.1 - 0.046 13.4 0.3 0.21 11.2 0.2 2.1 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB1_HrpK) Sel1 PF08238.12 EMD70225.1 - 0.05 14.3 4.8 1.6 9.5 0.0 4.4 4 0 0 4 4 4 0 Sel1 repeat HET PF06985.11 EMD70226.1 - 7e-21 75.1 0.3 1.3e-20 74.2 0.3 1.5 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Aminotran_4 PF01063.19 EMD70227.1 - 1.3e-16 61.1 0.1 7.9e-11 42.2 0.1 3.0 2 1 0 2 2 2 2 Amino-transferase class IV DEC-1_N PF04625.13 EMD70227.1 - 1.9 7.4 4.9 2.4 7.1 4.9 1.2 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region DUF4064 PF13273.6 EMD70228.1 - 0.84 9.9 8.7 0.72 10.2 5.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) Tyrosinase PF00264.20 EMD70229.1 - 3e-51 174.9 0.1 4.8e-51 174.2 0.1 1.3 1 0 0 1 1 1 1 Common central domain of tyrosinase FAD_binding_3 PF01494.19 EMD70229.1 - 1.4e-14 54.1 0.0 7e-07 28.8 0.0 2.7 2 1 0 2 2 2 2 FAD binding domain Pyr_redox_2 PF07992.14 EMD70229.1 - 0.0024 17.2 0.0 2 7.6 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EMD70229.1 - 0.0028 17.3 0.1 0.0065 16.1 0.1 1.6 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EMD70229.1 - 0.011 15.0 0.0 1.5 8.0 0.0 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EMD70229.1 - 0.027 14.7 3.0 0.081 13.2 0.4 3.1 3 1 1 4 4 4 0 NAD(P)-binding Rossmann-like domain DUF3455 PF11937.8 EMD70231.1 - 2.8e-32 112.3 1.0 3.7e-32 111.9 1.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3455) p450 PF00067.22 EMD70232.1 - 1.1e-58 199.2 0.0 1.2e-58 199.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Ten1 PF12658.7 EMD70233.1 - 2.8e-35 120.9 0.0 3.1e-35 120.8 0.0 1.0 1 0 0 1 1 1 1 Telomere capping, CST complex subunit Ten1_2 PF15490.6 EMD70233.1 - 1.1e-06 28.3 0.0 1.5e-06 27.9 0.0 1.1 1 0 0 1 1 1 1 Telomere-capping, CST complex subunit Rep_fac-A_3 PF08661.11 EMD70233.1 - 8.5e-05 22.9 0.0 0.00011 22.5 0.0 1.2 1 0 0 1 1 1 1 Replication factor A protein 3 DUF1315 PF07023.12 EMD70233.1 - 0.096 12.8 0.1 0.13 12.3 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1315) Snf7 PF03357.21 EMD70234.1 - 5.6e-41 140.0 18.9 5.6e-41 140.0 18.9 2.0 1 1 1 2 2 2 1 Snf7 DUF4483 PF14825.6 EMD70234.1 - 0.02 14.7 2.1 0.033 13.9 2.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4483) FidL_like PF15941.5 EMD70234.1 - 0.092 13.2 1.5 0.21 12.1 1.1 1.8 1 1 0 1 1 1 0 FidL-like putative membrane protein OrfB_IS605 PF01385.19 EMD70234.1 - 0.43 10.8 4.2 0.86 9.8 4.2 1.4 1 0 0 1 1 1 0 Probable transposase Ribosomal_60s PF00428.19 EMD70234.1 - 0.61 10.7 4.9 0.41 11.3 1.5 2.2 1 1 0 2 2 2 0 60s Acidic ribosomal protein DUF4795 PF16043.5 EMD70234.1 - 1.1 8.8 18.2 15 5.1 18.3 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) DUF3138 PF11336.8 EMD70234.1 - 2.3 6.7 5.2 3.6 6.1 4.7 1.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3138) ARA70 PF12489.8 EMD70234.1 - 3.2 8.0 8.6 0.7 10.1 3.6 2.0 2 0 0 2 2 2 0 Nuclear coactivator DUF1664 PF07889.12 EMD70234.1 - 3.7 7.6 11.0 2.8 8.0 4.4 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Herpes_UL14 PF03580.14 EMD70234.1 - 3.9 7.7 14.2 0.14 12.4 6.7 2.1 1 1 1 2 2 2 0 Herpesvirus UL14-like protein Forkhead PF00250.18 EMD70235.1 - 7.6e-25 87.0 0.2 1.7e-24 85.9 0.2 1.6 1 0 0 1 1 1 1 Forkhead domain FHA PF00498.26 EMD70235.1 - 3e-05 24.3 0.0 6.5e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 FHA domain 2OG-FeII_Oxy_3 PF13640.6 EMD70236.1 - 1.1e-07 32.6 0.0 2.6e-07 31.5 0.0 1.5 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily Transposase_28 PF04195.12 EMD70236.1 - 0.056 13.7 0.1 0.1 12.8 0.1 1.4 1 0 0 1 1 1 0 Putative gypsy type transposon CCDC53 PF10152.9 EMD70237.1 - 0.16 12.4 0.1 0.38 11.2 0.1 1.7 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex MFS_1 PF07690.16 EMD70238.1 - 7.2e-30 104.1 30.1 1.1e-29 103.5 30.1 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily BTP PF05232.12 EMD70238.1 - 0.052 13.6 1.0 0.052 13.6 1.0 3.4 3 1 1 4 4 4 0 Chlorhexidine efflux transporter Peptidase_U4 PF03419.13 EMD70238.1 - 0.93 8.7 22.4 0.016 14.5 11.1 2.4 2 1 0 2 2 2 0 Sporulation factor SpoIIGA Methyltransf_25 PF13649.6 EMD70240.1 - 3.9e-06 27.5 0.0 6.9e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EMD70240.1 - 4.1e-05 24.1 0.0 7.6e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EMD70240.1 - 0.0027 17.5 0.0 0.004 17.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Aminotran_3 PF00202.21 EMD70241.1 - 1.6e-89 300.4 0.0 2e-89 300.1 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Fungal_trans PF04082.18 EMD70242.1 - 4.9e-10 38.9 0.0 7.6e-10 38.3 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Peptidase_S28 PF05577.12 EMD70245.1 - 2.3e-30 105.8 1.3 4.4e-30 104.8 1.3 1.4 1 1 0 1 1 1 1 Serine carboxypeptidase S28 p450 PF00067.22 EMD70247.1 - 1e-15 57.5 0.0 1.1e-15 57.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 GLTP PF08718.11 EMD70247.1 - 0.054 13.8 0.0 0.074 13.3 0.0 1.2 1 0 0 1 1 1 0 Glycolipid transfer protein (GLTP) p450 PF00067.22 EMD70248.1 - 9e-11 41.2 0.0 9.1e-11 41.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Dmrt1 PF12374.8 EMD70249.1 - 0.39 11.2 4.6 1.2 9.6 4.6 1.8 1 0 0 1 1 1 0 Double-sex mab3 related transcription factor 1 AIF_C PF14721.6 EMD70249.1 - 0.94 9.8 3.8 2 8.8 0.9 2.2 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Glyco_hydro_92 PF07971.12 EMD70250.1 - 5e-137 457.6 4.2 6e-137 457.3 4.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 Glyco_hydro_92N PF17678.1 EMD70250.1 - 6.6e-46 157.1 1.1 1e-45 156.5 1.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 N-terminal domain # # Program: hmmscan # Version: 3.2.1 (June 2018) # Pipeline mode: SCAN # Query file: /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Bipolaris_sorokiniana_ND90Pr-Cocsa1/GCA_000338995.1_Cocsa1_protein.faa # Target file: /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm # Option settings: /oak/stanford/groups/akundaje/marinovg/programs/hmmer-3.2.1/bin/hmmscan -o /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Bipolaris_sorokiniana_ND90Pr-Cocsa1/GCA_000338995.1_Cocsa1_protein.PFam32-A --tblout /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Bipolaris_sorokiniana_ND90Pr-Cocsa1/GCA_000338995.1_Cocsa1_protein.PFam32-A.tblout --cpu 20 /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Bipolaris_sorokiniana_ND90Pr-Cocsa1/GCA_000338995.1_Cocsa1_protein.faa # Current dir: /oak/stanford/groups/akundaje/marinovg/genomes # Date: Sun Mar 24 15:45:12 2019 # [ok]